SGTCid condition conc unit NUM1|YDR150W.score NUM1|YDR150W.strain.pval NUM1|YDR150W.strain.significant NUM1|YDR150W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2247 cerulenin 830 nM 9.80087025621807 4.96376750060221e-16 yes 1 5.58098916528542e-23 1 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_58 0957-0393 9 µM 8.65503352886837 6.74283581563819e-13 yes 2 2.46383391930259e-18 108 6997992
SGTC_575 k072-0246 11.9 µM 6.99674436880354 4.99252716525841e-09 yes 3 1.30989323058595e-12 6 6796779
SGTC_138 0850-0259 40.9225 µM 6.43353698627135 6.83318013053785e-08 yes 4 6.23341202365532e-11 93 6813004
SGTC_580 1123-0028 41 µM 6.12663367711563 2.60649571867593e-07 yes 5 4.48788996068008e-10 3 1677248 YPR107C YTH1
SGTC_1029 k015-0030 64.7 µM 6.12010854550178 2.67997346805365e-07 yes 6 4.67558178424018e-10 5 2208316
SGTC_1078 idebenone 36.1 µM 5.80993604830763 9.73224297873166e-07 yes 7 3.12483555904631e-09 13 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_532 1548-0774 215 µM 5.70041513910482 1.51186597133105e-06 yes 8 5.97580084565745e-09 2 5932993
SGTC_1406 3909-7906 11.9 µM 5.50930684624609 3.20082127522146e-06 yes 9 1.8012472549195e-08 1 X1406
SGTC_2296 7971656 126.45 µM 5.37965897858738 5.25319650095188e-06 yes 10 3.73135338063557e-08 18 666570
SGTC_115 0527-0192 112.043 µM 5.32615120873796 6.42471355204354e-06 yes 11 5.01578155445786e-08 24 4233931
SGTC_1786 berberine 21.6 µM 5.06832456258899 1.65168815914333e-05 yes 12 2.00666324542489e-07 16 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2809 7964133 12.99 µM 5.01792217345121 1.97664085454005e-05 yes 13 2.61166636561383e-07 14 1253665
SGTC_596 1155-0152 116 µM 4.94502944036851 2.55553406127475e-05 yes 14 3.80661789552969e-07 16 280313
SGTC_1082 camptothecin 424.86 nM 4.78676120013867 4.4117354286947e-05 yes 15 8.47471526930926e-07 35 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1038 k292-0204 154 µM 4.71074149543642 5.70211956318495e-05 yes 16 1.2340857005355e-06 6 4454212
SGTC_44 0929-0055 61.211 µM 4.69812485568301 5.94804694726292e-05 yes 17 1.31280457712606e-06 21 1379590
SGTC_1573 oleylamine 1.06 µM 4.66776029986052 6.58154794036053e-05 yes 18 1.52250423993013e-06 15 5356789 An amine of the fatty acid oleic acid.
SGTC_736 0958-0254 92.6 µM 4.61857738992555 7.74426979793222e-05 yes 19 1.93189937719724e-06 16 6812352
SGTC_2697 mebhydrolin 72.4 µM 4.56109170901514 9.34785888739475e-05 yes 20 2.54441737719924e-06 53 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1534 6-azauridine 81.6 µM 4.55309786884055 9.59412244929324e-05 yes 21 2.64308328401874e-06 11 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1554 st069299 38.7 µM 4.49610425735612 0.000115348036285218 yes 22 3.46049052048918e-06 11 24207999
SGTC_332 4112-0506 40.9 µM 4.47590725406631 0.000123068426533329 yes 23 3.80437557776942e-06 17 2790355
SGTC_1290 0986-0249 10.2 µM 4.43431137789661 0.000140520402805903 yes 24 4.61835237031311e-06 15 53329
SGTC_2320 7373003 200 µM 4.32992848990269 0.000195059194472641 yes 25 7.45788852608764e-06 19 5415828
SGTC_1844 rapamycin 4 nM 4.3083816089861 0.000208541759915661 yes 26 8.22267327547457e-06 137 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_795 0685-0265 78 µM 4.29626447330708 0.000216501243929551 yes 27 8.68501671477217e-06 14 302754
SGTC_515 4092-1064 102 µM 4.27538599129922 0.000230884755849419 yes 28 9.54032122354501e-06 53 717353
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 4.27334937243765 0.000232334545734475 yes 29 9.62791907594041e-06 25 5379071
SGTC_1367 1812-0510 76.9 µM 4.2619831530752 0.000240582912019518 yes 30 1.0131036080531e-05 16 1142582 YDR527W RBA50
SGTC_1195 1502-0147 41.1 µM 4.26176653536209 0.000240742729715042 yes 31 1.01408633615409e-05 15 817940
SGTC_2242 6630449 61.2675 µM 4.17041869449072 0.000317705636318063 yes 32 1.52020258491577e-05 42 691249 YDR170C SEC7
SGTC_2092 5303694 80.6725 µM 4.15293852327211 0.000334824528010348 yes 33 1.64116470460919e-05 38 1963699
SGTC_3304 9125678 46.087 µM 4.09651305449156 0.00039611288115341 yes 34 2.09709923432818e-05 40 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_722 3534-0461 190 µM 3.99984725300495 0.000525844857315992 yes 35 3.16916902441038e-05 36 658262
SGTC_3156 9099931 49.47 µM 3.95980658105453 0.000590302384468849 yes 36 3.75052457085512e-05 8 18111053
SGTC_456 gingerol 170 µM 3.93115320145422 0.000640828064033054 yes 37 4.22696885491626e-05 17 442793 A herb.
SGTC_1105 epirubicin 18.1 µM 3.9069345704994 0.000686615580368365 yes 38 4.67372260065991e-05 20 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1570 verbenone 133 µM 3.84928156022155 0.000808016063031232 yes 39 5.92323871352223e-05 17 29025 A natural terpanoid with antifungal properties.
SGTC_1250 0485-0349 40.2 µM 3.84324143674354 0.000821817346088179 yes 40 6.07099564927061e-05 40 6842794 YDL195W SEC31
SGTC_1731 st035964 63 µM 3.80856745217406 0.000905330681210408 yes 41 6.98871097894477e-05 33 6739575
SGTC_905 2-aminofluorene 215 µM 3.77964977917017 0.000980869831272103 yes 42 7.85245498533023e-05 34 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2661 dactinomycin 12.96 µM 3.64573345702643 0.00141197995827084 no 43 0.000133315115109458 30 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3017 9080681 49.47 µM 3.63586246700939 0.0014497677548293 no 44 0.000138526062886261 20 16451914
SGTC_2294 7971431 200 µM 3.62616581954471 0.00148778469066356 no 45 0.00014383033645143 19 5741572
SGTC_1269 0831-0796 3.05 µM 3.58787520269145 0.00164696061768301 no 46 0.000166691892090581 21 927758
SGTC_864 0469-0573 172 µM 3.5779292309057 0.00169077000277951 no 47 0.00017316359329414 30 689425
SGTC_1833 st055984 71 µM 3.57106035176514 0.00172164221436831 no 48 0.000177769475981365 27 676288
SGTC_1150 3909-7983 10.9 µM 3.56055804392948 0.00176983782906964 no 49 0.000185033747312572 38 23965914
SGTC_788 1182-0090 188 µM 3.5488134718089 0.00182518576721824 no 50 0.00019348554689263 100 5715185
SGTC_3242 9133940 49.47 µM 3.53812197962001 0.00187693465229519 no 51 0.000201491923707279 20 17248444
SGTC_899 1083-0020 478 µM 3.51436644660382 0.00199672092355225 no 52 0.000220402132688479 33 767123
SGTC_1415 3966-0071 78.1 µM 3.5091687325501 0.00202383846278462 no 53 0.000224754816507507 19 2893185
SGTC_1267 0828-0272 9.49 µM 3.5005814065066 0.00206937350070492 no 54 0.000232122211559989 34 745334
SGTC_2248 tofa 1.1 µM 3.49915433894374 0.00207703009825608 no 55 0.000233368165957404 52 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_310 1273-0058 1.06 µM 3.49549088103254 0.00209680335136088 no 56 0.00023659531078834 289 2734232
SGTC_2321 7390090 138.78 µM 3.49245340530795 0.00211332722825576 no 57 0.000239302544119725 44 649046
SGTC_3106 9121286 49.47 µM 3.47914714142926 0.00218711416736808 no 58 0.000251506157992249 26 15943471
SGTC_1288 0973-0013 65.5 µM 3.46374849661696 0.00227541366860487 no 59 0.000266352157727645 29 4315430
SGTC_1694 st024011 44.9 µM 3.42052844609413 0.00254076370307898 no 60 0.000312497995198143 57 2787533
SGTC_2957 9076800 11.52 µM 3.40990482721262 0.00261013084537956 no 61 0.000324927763594554 36 16459615
SGTC_1682 st012968 530 nM 3.38155040837458 0.00280372702206937 no 62 0.000360390034495395 39 24207270
SGTC_1800 st050079 29.0735 µM 3.37978618223722 0.00281619028787885 no 63 0.000362711204061529 171 3645560
SGTC_576 1073-0113 22.7 µM 3.37502724931972 0.00285005910297675 no 64 0.000369041911378498 89 5439563
SGTC_2052 5265182 7.135 µM 3.35843033856006 0.00297107136035272 no 65 0.000391932378747407 49 1239884
SGTC_1801 st050089 28.441 µM 3.35187878256906 0.00302010142324339 no 66 0.000401325772074465 163 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3031 9088762 49.47 µM 3.34837739999409 0.00304660261141481 no 67 0.000406431182095766 43 205253
SGTC_2123 5259487 200 µM 3.31875178440882 0.00327935242310437 no 68 0.000452103823085424 39 2173474
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 3.29480877345529 0.00347901081204768 no 69 0.000492443381583472 45 5106787 A p450 inhibitor.
SGTC_2864 9034755 47.6 µM 3.2308936994584 0.0040665240043125 no 70 0.000617019124847755 36 4930451
SGTC_427 1354-0053 47.3 µM 3.22356235787943 0.0041392985857039 no 71 0.000633033647577496 51 6813657
SGTC_121 0557-0495 61.343 µM 3.21891787549338 0.00418600286261086 no 72 0.000643376659964228 106 3104427
SGTC_2806 7952793 58.44 µM 3.21349459906083 0.00424113472841986 no 73 0.000655651320974957 54 2972490
SGTC_1258 0671-0043 57.1 µM 3.2003580859573 0.00437737802750988 no 74 0.000686284718363048 61 4298767
SGTC_98 0074-0023 107.663 µM 3.1992592977977 0.0043889492763977 no 75 0.000688905931598754 74 3563821
SGTC_431 k089-0097 107 µM 3.18152125376368 0.00457956664487199 no 76 0.000732518864347009 79 5499420
SGTC_1368 1852-0141 284 µM 3.15968749221103 0.00482432203254757 no 77 0.000789692219537674 70 2838987
SGTC_1775 st081588 35.1725 µM 3.14997276304169 0.00493692354763731 no 78 0.000816428423193458 54 1426443 YGL099W LSG1
SGTC_1908 st060353 56.5 µM 3.14480428938452 0.00499777959292671 no 79 0.000830989861247483 79 4227716
SGTC_489 paxilline 115 µM 3.14237537788431 0.00502660883719586 no 80 0.000837915176831931 49 105008 A toxic potassium channel blocker.
SGTC_3141 9094609 49.47 µM 3.13484767605644 0.00511689969518318 no 81 0.0008597168404116 75 25236309 YDL196W YDL196W
SGTC_3066 9117245 49.47 µM 3.13483582362725 0.00511704298995034 no 82 0.000859751574903228 39 17176980
SGTC_385 1494-0393 12.4 µM 3.13206258784341 0.00515066951349191 no 83 0.000867914335340634 68 3090647
SGTC_1942 st076330 65.2 µM 3.10467312830789 0.00549348839632629 no 84 0.000952447050408739 62 24208414
SGTC_1817 st052116 64.4 µM 3.09732038089773 0.00558890499150688 no 85 0.000976393492551527 35 4361398
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 3.09491365197061 0.00562045532098608 no 86 0.000984351009914566 59 688751
SGTC_62 0180-0423 3.232 µM 3.0749974569319 0.00588766958279121 no 87 0.00105252174280606 54 30102 YGL099W LSG1
SGTC_1702 st027038 51 µM 3.06921175259204 0.0059673796490403 no 88 0.00107312203519305 48 5521182
SGTC_3280 9140961 49.47 µM 3.03156892562047 0.00650974978285539 no 89 0.00121643184598315 47 4901226
SGTC_916 4466-0038 42 nM 3.03036786260846 0.00652775078708551 no 90 0.00122128020132563 136 5722064 YGL116W CDC20
SGTC_13 0199-0087 65 µM 3.02879830963369 0.00655134090669815 no 91 0.0012276427026929 35 4589825
SGTC_1556 plumbagin 1.48 µM 3.00437857478739 0.00692819941905151 no 92 0.001330619807632 46 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2585 alliin 100 µM 2.99937049001992 0.00700781078614965 no 93 0.0013526905603083 79 87310 A garlic compound which reacts with lipids.
SGTC_830 4076-0286 57.8 µM 2.99460112966258 0.00708437678776274 no 94 0.0013740197072347 148 6866659
SGTC_1439 4092-1168 46 µM 2.992638719721 0.00711609451265717 no 95 0.00138288470933595 39 2886240
SGTC_2703 st077852 53.4 µM 2.98099877509656 0.00730681480623626 no 96 0.00143654971000149 68 6281836
SGTC_956 1185-0240 191 µM 2.96782076809831 0.00752816245084878 no 97 0.0014995958023731 69 1416193
SGTC_2106 5357045 167.29 µM 2.95889166895085 0.00768147904997287 no 98 0.00154373808299427 57 668842
SGTC_1396 3511-0007 98.6 µM 2.94705891459907 0.00788888377348457 no 99 0.001604060375273 51 X1396
SGTC_2961 9083290 32.55 µM 2.93772429733981 0.00805596064975532 no 100 0.00165315453797073 53 17741490
SGTC_1616 st002734 56.1 µM 2.90254654048063 0.00871386521082742 no 101 0.00185071078639263 86 4026101
SGTC_248 streptozotocin 5.23457 mM 2.90114805461223 0.00874096674979378 no 102 0.00185899083310633 61 5300 DNA alkylating agent.
SGTC_517 1365-0151 113 µM 2.88758085485049 0.00900774789848908 no 103 0.00194108406900458 86 768657
SGTC_375 3970-0961 9.27 µM 2.88725834939372 0.00901417539130439 no 104 0.00194307496657117 75 2898222
SGTC_1012 4112-3522 18 µM 2.8852041110029 0.00905521046422862 no 105 0.00195579983018098 63 3112398
SGTC_435 c-PAF 6.7 µM 2.86442068755976 0.0094796629692743 no 106 0.00208886380680893 110 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2507 purpurin 79.67 µM 2.86277585113208 0.00951398605370254 no 107 0.00209973765846502 101 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1204 4049-0315 18.3 µM 2.84923171357291 0.00980076886294204 no 108 0.00219124749284395 93 588402
SGTC_2271 7849410 118.62 µM 2.83910730530949 0.010020046707444 no 109 0.0022619970369429 51 972430
SGTC_451 chloral hydrate 100 µM 2.83899397506655 0.0100225252920503 no 110 0.00226280057017317 130 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1251 0490-5699 265 µM 2.79151733016911 0.0111090952378953 no 111 0.0026230774102263 107 3883818
SGTC_445 e6 berbamine 66 µM 2.78899036236221 0.0111696959299441 no 112 0.00264363192012264 216 6610268 A calcium/calmodulin antagonist.
SGTC_920 mycophenolic acid 780.421 nM 2.78029980036575 0.0113803087071302 no 113 0.00271543673223371 95 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2164 5685496 200 µM 2.77999030272317 0.0113878724831076 no 114 0.00271802608698803 70 759046
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.77649158596511 0.0114736814460668 no 115 0.00274745286453845 76 16486 A toxic proline analog.
SGTC_286 k060-0067 22.9 µM 2.77491675240831 0.0115124884991035 no 116 0.00276079197304499 70 5985051
SGTC_1173 0443-0020 122 µM 2.76223658119395 0.0118291288555484 no 117 0.0028703432221994 119 5331295
SGTC_681 1642-0006 26.6 µM 2.7587958543875 0.0119163409612176 no 118 0.00290073821386959 26 4446530
SGTC_220 paclitaxel 373.376 µM 2.75474114265 0.012019831165436 no 119 0.00293692936288015 40 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3005 9076496 71.4286 µM 2.75154006638066 0.0121020833058626 no 120 0.00296578816507082 47 21368410
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.75085968022717 0.0121196286740357 no 121 0.00297195491368335 30 4620898
SGTC_2336 9001819 198.65 µM 2.74908712142967 0.0121654418893519 no 122 0.00298807498084141 136 2989602
SGTC_3147 9097027 49.47 µM 2.74857209813468 0.0121787811931623 no 123 0.00299277347262488 82 25236841
SGTC_432 NS 1619 61.3 µM 2.74084879474123 0.0123803433897508 no 124 0.0030640350602777 96 4552 A K+/calcium channel activator.
SGTC_3110 9122132 49.47 µM 2.73131531065416 0.0126331269631295 no 125 0.00315410433120027 64 918317
SGTC_1443 4112-3303 14 µM 2.72622859329084 0.0127698216764469 no 126 0.00320313069628002 58 704433
SGTC_2671 danthron 100 µM 2.71465391037966 0.0130856434662248 no 127 0.00331725319012239 113 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2202 7226349 200 µM 2.70630737262484 0.0133175523246582 no 128 0.00340180202770353 59 844334
SGTC_2642 cholecalciferol 100 µM 2.70407654909224 0.0133801338162297 no 129 0.00342472540191125 68 9821465 A vitamin D precursor, similar to steriods.
SGTC_803 4488-1585 147 µM 2.69852015000472 0.0135371130571896 no 130 0.00348242606768015 68 747204
SGTC_1098 clofazimine 15.1 µM 2.69680424327611 0.0135859109698498 no 131 0.00350042060982839 112 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1510 1123-0200 71.5 µM 2.69662454596202 0.0135910300732077 no 132 0.00350230989975684 133 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_832 4083-0019 164 µM 2.68269370729484 0.0139929829978052 no 133 0.00365159218407265 241 1990758
SGTC_2108 5365811 200 µM 2.67811574987412 0.0141272909924052 no 134 0.00370188138257251 91 780283
SGTC_3311 9131146 2.8755 µM 2.6761852012432 0.0141842615063129 no 135 0.00372327418641301 208 4900406 YPR165W RHO1
SGTC_2350 9023895 38.85 µM 2.67513678597209 0.0142152831052523 no 136 0.0037349382882951 107 2997209
SGTC_1847 st056231 15 µM 2.6690485835703 0.0143965847278883 no 137 0.00380332232642088 136 5393180
SGTC_389 tpck 16.7 µM 2.66898311800206 0.0143985450076937 no 138 0.00380406371009463 96 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_184 1494-0393 24.714 µM 2.64540044617764 0.0151198161034984 no 139 0.00407971463303387 159 3090647
SGTC_586 0957-0265 8.15 µM 2.63431502073567 0.0154694514006622 no 140 0.00421536138619503 95 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2382 9035899 200 µM 2.63144019833245 0.0155612488947309 no 141 0.00425119145439266 76 6462679
SGTC_3306 9127676 59.7925 µM 2.62801381740222 0.0156712687814144 no 142 0.00429425135368907 96 41905287
SGTC_116 0155-0182 31.788 µM 2.62793723971521 0.0156737352687926 no 143 0.00429521815673551 212 771486
SGTC_196 k015-0023 18.111 µM 2.62332734099721 0.0158228300630297 no 144 0.00435377836284475 88 5211998
SGTC_869 0564-0080 44.1 µM 2.62273977843124 0.0158419203072921 no 145 0.00436129329322676 108 6843321
SGTC_2937 9044753 11.33 µM 2.61493905542232 0.0160972479789429 no 146 0.00446216889340612 131 6465530 YGL099W LSG1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.59969670792745 0.0166063381924397 no 147 0.00466530925525023 137 6728940
SGTC_361 000s-0510 1.45 µM 2.59709763606897 0.0166945074269124 no 148 0.00470075980769879 137 660
SGTC_678 1218-2179 85.9 µM 2.59054354567755 0.0169186243888724 no 149 0.00479122486879323 37 6820081 YOR116C RPO31
SGTC_3067 9117431 49.47 µM 2.59049275521643 0.0169203711639117 no 150 0.00479193194126464 81 17150885
SGTC_3020 9089140 49.47 µM 2.58489803987017 0.0171137298419556 no 151 0.00487038989840549 105 17217859
SGTC_792 4534-1957 155 µM 2.57699215669854 0.0173901823138954 no 152 0.00498321060335164 117 1717904
SGTC_472 calcifediol 10 µM 2.5730758869639 0.0175285328810695 no 153 0.00503995516602073 52 5283731 A vitamin D metabolite.
SGTC_1088 bifonazole 369 nM 2.57240551660483 0.0175523090824843 no 154 0.0050497259289022 88 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1745 st081495 74 µM 2.5670587547057 0.0177429313908032 no 155 0.00512826159926579 207 13842402 YBL026W LSM2
SGTC_3108 9121785 49.47 µM 2.55793997989545 0.0180721085331555 no 156 0.00526471320045824 95 17140271
SGTC_2016 5121758 140 µM 2.55418945657627 0.0182090013514315 no 157 0.00532176627398189 158 2795203
SGTC_1196 1588-0294 184 µM 2.5521605654543 0.0182834228013752 no 158 0.00535285843631348 86 6144269
SGTC_1809 st050081 57.6 µM 2.5434086987567 0.0186074257362414 no 159 0.00548883710415507 110 5036894
SGTC_1342 1486-1464 234 µM 2.53008111020047 0.0191102100498856 no 160 0.00570180806648137 102 3253938
SGTC_1458 k015-0034 6.33 µM 2.52531277413923 0.0192928798275716 no 161 0.00577976786931837 91 3598957
SGTC_1444 4112-3581 28 µM 2.52134227953002 0.0194461153886639 no 162 0.00584540358808116 96 2877249
SGTC_1089 terbinafine 2.25 µM 2.50894284945626 0.0199313260448881 no 163 0.0060546537145071 107 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1802 st050112 57.9 µM 2.48424856968893 0.0209283020028906 no 164 0.00649125756393263 90 4662563
SGTC_1023 4482-3888 16 µM 2.47892612890265 0.0211486260260157 no 165 0.00658892976068535 114 3303168
SGTC_1188 1403-0014 4.57 µM 2.46958179219068 0.0215401844387621 no 166 0.00676355453236607 180 9614867
SGTC_2104 5389443 200 µM 2.45393379644984 0.022209604918911 no 167 0.00706514966390029 125 2244536
SGTC_3084 9116877 49.47 µM 2.45135934273308 0.0223214044480364 no 168 0.00711588983346292 67 27241325
SGTC_708 3448-5400 146 µM 2.45038918460209 0.0223636580108773 no 169 0.00713509402212721 171 3462195
SGTC_129 0088-0017 176.636 µM 2.43986127563465 0.0228265372907768 no 170 0.00734645147091533 180 182446
SGTC_824 1304-0008 100 µM 2.43679527037667 0.0229628482148838 no 171 0.00740903310155169 154 768245
SGTC_730 1436-0052 41.2 µM 2.43450467456507 0.0230651322663204 no 172 0.00745609361968761 96 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3219 9131112 49.47 µM 2.42637714421041 0.0234311593181925 no 173 0.00762520640358016 131 17612988 YMR079W SEC14
SGTC_467 ro 31-8220 72.8 µM 2.41107879350777 0.0241333904572944 no 174 0.00795270591862724 205 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1862 st057513 3.81 µM 2.40978872167356 0.0241934077812172 no 175 0.00798088048112394 95 5393163
SGTC_1633 st005664 67.9 µM 2.40801171280929 0.0242762838476099 no 176 0.0080198332082866 168 2063822
SGTC_2252 omeprazole 400 µM 2.40121546263334 0.0245954497933026 no 177 0.0081703558793982 66 4594 A proton pump inhibitor.
SGTC_1757 st041620 31.8375 µM 2.3981448725311 0.0247408017414823 no 178 0.00823917323127562 145 5289815
SGTC_712 r015-0009 80.6 µM 2.39660602228547 0.0248139166371372 no 179 0.0082738527141384 108 6813872 YLR060W FRS1
SGTC_932 2857-0803 154 µM 2.39181031493556 0.025042936916191 no 180 0.00838275228823309 125 674898
SGTC_2730 imipramine 71.33 µM 2.38048004902628 0.0255910630050236 no 181 0.00864504864082919 171 3696 A tricyclic antidepressant.
SGTC_1835 st008666 49.2 µM 2.38017713574218 0.025605853868476 no 182 0.00865215880941223 110 690455
SGTC_2384 9036245 200 µM 2.38010691332312 0.0256092837600169 no 183 0.00865380784571631 131 6462766
SGTC_1825 st052143 62.6 µM 2.37861288082398 0.0256823483685349 no 184 0.00868895765733849 106 674173
SGTC_1255 0566-0045 221 µM 2.37631292691325 0.0257951670242583 no 185 0.008743312946498 161 2788469
SGTC_273 hydroxyurea 18.1 mM 2.37214584486346 0.0260006296074214 no 186 0.00884255417669617 160 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2178 5812956 200 µM 2.3683005643423 0.0261914381445188 no 187 0.00893500594906171 126 5403383
SGTC_1949 st076024 69.1 µM 2.35565434641814 0.0268272376884241 no 188 0.00924505691799917 157 2921930
SGTC_529 4076-0302 30.3 µM 2.34308328577157 0.0274719796329232 no 189 0.00956255665376749 124 5816522
SGTC_514 4466-0038 2.65 nM 2.33106402336287 0.0281004519047218 no 190 0.00987499199291304 317 5722064
SGTC_1523 st012844 44.7 µM 2.3206561306297 0.0286542963836912 no 191 0.0101527050840647 154 4274103
SGTC_2358 9037157 4 µM 2.3197450081179 0.0287032099398693 no 192 0.0101773377549392 159 2388925
SGTC_296 1222-0039 74.9 µM 2.31848331699717 0.0287710583762736 no 193 0.01021153430512 130 5984176
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.3180014652864 0.0287970054955355 no 194 0.010224620711752 156 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_97 0535-0701 19.132 µM 2.31335885314444 0.0290480025583585 no 195 0.0103514586929089 135 2832013 YGL099W LSG1
SGTC_2958 9077254 16.72 µM 2.30697333018086 0.0293961951212125 no 196 0.0105281534697667 159 16457351
SGTC_473 2-arachidonoylglycerol 10 µM 2.3006657930763 0.0297435305207189 no 197 0.0107052645104433 142 5282280 An endocannabinoid.
SGTC_1360 1598-0022 39.8 µM 2.29953111773542 0.0298063733301211 no 198 0.0107373992312419 217 761525
SGTC_1931 st074438 57.1 µM 2.29933203662475 0.0298174105800068 no 199 0.0107430459860949 129 2787313
SGTC_625 k213-0058 121 µM 2.29530815900358 0.0300412260785185 no 200 0.0108577351832126 317 3655420
SGTC_2447 5741742 33.78 µM 2.29372270451057 0.0301297937138986 no 201 0.0109032158700976 163 1776504
SGTC_3331 9141060 1.957 µM 2.27796022659993 0.0310221566991728 no 202 0.0113644737048663 143 4906567 YPR165W RHO1
SGTC_854 0422-0053 192 µM 2.27765041075726 0.03103991315307 no 203 0.0113737072310781 136 3596728
SGTC_3101 9120531 49.47 µM 2.27646266303153 0.0311080643925552 no 204 0.0114091664261928 179 24824904
SGTC_577 r071-0003 38.6 µM 2.27302358432816 0.0313060921822871 no 205 0.0115123793710991 243 4568517 YMR134W ERG29
SGTC_1377 2944-0135 198 µM 2.27080441519467 0.0314344281120617 no 206 0.0115794102806913 182 1894137
SGTC_1433 4060-0023 7.6 µM 2.27027107698467 0.0314653361345604 no 207 0.0115955704002435 138 3840627
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.25895922468258 0.0321268200552994 no 208 0.0119429606956527 244 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_751 0833-0568 350 µM 2.25809574144709 0.0321777821634796 no 209 0.0119698455443136 151 6954252
SGTC_1964 st076914 61 µM 2.24935350400781 0.0326975096393053 no 210 0.0122450071425963 126 24208661
SGTC_1652 st011932 78 µM 2.24084315787352 0.0332100808330899 no 211 0.0125181181400428 136 1551076
SGTC_955 1216-0110 33 µM 2.23329127946603 0.0336704496895334 no 212 0.0127648711111202 237 3619719
SGTC_1992 st073643 23.3 µM 2.23304183820801 0.0336857449900702 no 213 0.0127730927411188 123 3161292
SGTC_2852 9023854 51.95 µM 2.23303446019591 0.0336861974838806 no 214 0.0127733359915021 160 19798528
SGTC_2082 5219693 150 µM 2.23067712599262 0.0338310292134156 no 215 0.0128512619349508 180 2834649
SGTC_3002 9075603 71.4286 µM 2.22496623904065 0.0341840237688347 no 216 0.0130417523258074 171 20105405
SGTC_2444 5485484 36.41 µM 2.21969709937419 0.0345123937670902 no 217 0.013219667942849 203 6790631
SGTC_1264 0783-0040 158 µM 2.21744683450119 0.0346534165582246 no 218 0.0132962861483061 168 2855798
SGTC_2291 7917025 104.35 µM 2.20376754440717 0.0355209054077936 no 219 0.0137703480909397 222 2964612
SGTC_1803 st050068 52.4 µM 2.19710935482769 0.0359495402975775 no 220 0.0140063185844618 423 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2890 9046729 58.44 µM 2.19376458531079 0.0361664604106343 no 221 0.0141261690169066 144 903329
SGTC_3228 9131799 49.47 µM 2.18726866784092 0.0365908053755497 no 222 0.0143614583064564 129 17015818
SGTC_2951 9072950 58.06 µM 2.18683698159361 0.0366191489599821 no 223 0.0143772133495765 193 16488155
SGTC_1955 wogonin 32.4 µM 2.18617980488509 0.0366623322410166 no 224 0.0144012265813671 148 5281703 A flavanone.
SGTC_744 1594-0068 283 µM 2.18074108317887 0.0370213133777103 no 225 0.0146012862542809 215 668392
SGTC_960 1222-0186 7.7 µM 2.1806244244467 0.0370290447639627 no 226 0.0146056035347635 181 3126296
SGTC_2679 rapamycin 1 nM 2.17340112042401 0.0375103353873808 no 227 0.0148750702935194 340 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3212 9128307 49.47 µM 2.16515758725833 0.0380658330823918 no 228 0.0151878095557457 196 27243542
SGTC_1741 st038134 10.228 µM 2.15370367665078 0.0388487856766423 no 229 0.0156317088188816 226 1272587
SGTC_1028 k015-0029 4.8 µM 2.1357761357331 0.0401005411176459 no 230 0.0163488325899923 218 4588309
SGTC_709 3807-1509 243 µM 2.12280491098894 0.0410265092173877 no 231 0.0168851015767752 131 1886677 YPL242C IQG1
SGTC_1446 4239-0190 62 µM 2.12268109955927 0.041035430508898 no 232 0.0168902919323973 231 1340085
SGTC_2005 4024620 188 µM 2.11721343580441 0.0414309771020311 no 233 0.017120868805588 182 236743
SGTC_2597 laccaic acid a 100 µM 2.10448171564146 0.0423640060784918 no 234 0.0176682239615535 223 5491415 A textile dye.
SGTC_1867 st057372 64 µM 2.10415621719787 0.0423880808622705 no 235 0.0176824111595122 174 688837
SGTC_2090 5301565 104.445 µM 2.09515452005999 0.0430582681740305 no 236 0.0180786293520732 237 2056344
SGTC_2728 chlorpromazine 9.18 µM 2.09124717555023 0.0433518267755049 no 237 0.0182529562032217 106 2726 A thorazine and dopamine antagonist.
SGTC_1451 4152-0210 104 µM 2.08964933884382 0.0434723367460655 no 238 0.0183246554901363 215 659563
SGTC_642 0335-0876 158 µM 2.08704615860165 0.0436692494600653 no 239 0.0184419811402339 215 6812350
SGTC_2862 9027634 71.43 µM 2.08324884540869 0.043957780153721 no 240 0.0186142734426083 196 5012562
SGTC_1930 st074634 34.3 µM 2.07911171698341 0.0442738789090894 no 241 0.0188035417019285 208 684253 YOR116C RPO31
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.07060622014809 0.0449294991067749 no 242 0.0191978052066284 197 688669
SGTC_2713 st079149 53.4 µM 2.06944847723508 0.0450193414072 no 243 0.0192520107219566 223 3103253
SGTC_3204 9114183 49.47 µM 2.06697116100578 0.0452120699776543 no 244 0.0193684357424077 210 17027248
SGTC_588 3970-1144 52.9 µM 2.06170381449093 0.0456240617049914 no 245 0.0196179715974993 227 1888707
SGTC_1812 st052057 4.327 µM 2.05743399163525 0.0459602412843631 no 246 0.0198222491285811 216 3645418
SGTC_1472 k841-0093 193 µM 2.05511822524865 0.0461434012081246 no 247 0.0199337934970611 226 X1472
SGTC_802 4112-3352 742 µM 2.05371824433211 0.0462544133363137 no 248 0.0200014848518243 223 704594
SGTC_1730 st033808 45.1 µM 2.04761720922168 0.0467407037761215 no 249 0.020298760881817 273 1045166
SGTC_3 0833-0587 95.581 µM 2.04289946808951 0.0471195422025875 no 250 0.0205311954999447 183 5382644
SGTC_1567 st069303 68.4 µM 2.03630373040797 0.0476533074351188 no 251 0.0208599327390925 227 5581319
SGTC_3305 9127027 53.8275 µM 2.03450265798851 0.0477998992775546 no 252 0.0209504704415032 209 41905295
SGTC_1662 st014054 52 µM 2.02457118042335 0.048614732535225 no 253 0.0214557080224556 157 2838777
SGTC_624 k048-0052 28 µM 2.01714373721066 0.0492313490600559 no 254 0.0218402577391302 199 6835531
SGTC_695 3505-6186 243 µM 2.01390875241304 0.0495018584023684 no 255 0.0220095572310276 209 1819379
SGTC_689 0833-0039 98 µM 2.01071614495142 0.0497699859852585 no 256 0.0221777238578674 212 5374726
SGTC_991 3996-0057 64.7 µM 2.00421381544789 0.0503196591696674 no 257 0.0225235806376112 201 715343
SGTC_2415 st077333 57.7 µM 1.99866027303619 0.050792947907685 no 258 0.0228225620734243 319 2766255
SGTC_2243 6634756 200 µM 1.99521150555626 0.0510886413496921 no 259 0.0230099083532999 182 885676
SGTC_1587 estradiol valerate 56.1 µM 1.9925547273093 0.0513173633708554 no 260 0.0231551134035708 202 13791 A steroid.
SGTC_1866 st057638 64 µM 1.99025199376799 0.051516263995518 no 261 0.0232815916897015 193 688802
SGTC_227 fluconazole 33.516 µM 1.98360113375206 0.0520941815350392 no 262 0.0236501613628432 299 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_329 k048-0121 21.3 µM 1.9820340021342 0.0522311022664826 no 263 0.0237377175954459 207 6832902
SGTC_3097 9117246 49.47 µM 1.97908468136379 0.0524895601946091 no 264 0.0239032364392981 231 16423892
SGTC_840 0245-0196 390 µM 1.97856282557524 0.0525353975311391 no 265 0.0239326242815157 237 3827528
SGTC_1872 amphotericin b 148 nM 1.97764420410817 0.0526161620644044 no 266 0.0239844293997735 216 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3172 9105863 49.47 µM 1.97560206662931 0.0527960583110564 no 267 0.0240999322011891 105 2348785
SGTC_1454 4239-0054 42.6 µM 1.97175358967381 0.0531364048589558 no 268 0.0243188713697189 263 1340767
SGTC_1871 st057448 67.3 µM 1.96846192212736 0.0534288872041317 no 269 0.0245074565993059 255 691747
SGTC_946 3434-1334 87.4 µM 1.96309678802127 0.0539083409017937 no 270 0.024817464355427 221 4047976
SGTC_3189 9110682 49.47 µM 1.95867226604165 0.054306294606669 no 271 0.025075590203105 221 17122418
SGTC_3166 9102297 49.47 µM 1.95552800830742 0.054590507892748 no 272 0.0252603904113217 260 25237072
SGTC_1335 1486-0900 202 µM 1.95358554989275 0.054766676013968 no 273 0.0253751254527689 277 X1335
SGTC_908 3448-7491 47.7 µM 1.95153765089182 0.0549528932503625 no 274 0.0254965609488793 391 1203031
SGTC_2040 5100729 123 µM 1.94863536815469 0.0552176569606197 no 275 0.0256694926300993 253 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_221 trifluoperazine 10.304 µM 1.94202945151446 0.0558240449952796 no 276 0.026066767506141 455 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2109 5483026 200 µM 1.94130700460073 0.0558906792801696 no 277 0.0261105252112728 273 759335
SGTC_348 k064-0012 10.7 µM 1.93935291097269 0.0560712278842752 no 278 0.0262291901026419 200 5066323
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.93495428895897 0.0564793217848924 no 279 0.0264979526437735 305 91467 include heat shock
SGTC_2999 9069765 71.4286 µM 1.93406881907699 0.056561755948145 no 280 0.0265523335184863 235 2097066
SGTC_878 0828-0289 13.7 µM 1.93353442898847 0.0566115516588606 no 281 0.0265851980239455 312 745350 YLR208W SEC13
SGTC_1097 itavastatin 7.23 µM 1.93318608444544 0.0566440298045458 no 282 0.0266066391873002 261 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_887 0885-0007 9.62 µM 1.92244180446676 0.0576530078172592 no 283 0.0272750948210959 271 5719458
SGTC_428 3448-4153 16.5 µM 1.91466863846405 0.058391744801772 no 284 0.0277673877742185 239 3834874
SGTC_345 1362-0200 395 µM 1.90990382137032 0.0588482401733952 no 285 0.0280727989840515 234 1419823
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.9097542631279 0.0588626138678081 no 286 0.0280824303386692 315 688664
SGTC_571 k831-0106 44.2 µM 1.90623611831552 0.0592015298394307 no 287 0.0283097890718208 229 4783639
SGTC_1358 1509-0022 2.48 µM 1.90548752777228 0.0592738414234133 no 288 0.0283583635885761 243 3258434
SGTC_2753 fluvastatin 17.09 µM 1.90448651228906 0.0593706446979663 no 289 0.0284234258090613 279 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_433 pimozide 108 µM 1.90080746718919 0.0597274922452761 no 290 0.0286636178260926 178 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3229 9132204 49.47 µM 1.88594029749598 0.0611866693777994 no 291 0.0296515001918436 164 17682924
SGTC_17 0960-0276 49.807 µM 1.88257053007168 0.0615212453000923 no 292 0.0298792966376676 304 6821114
SGTC_2522 biochanin a 4.94 µM 1.88000264545086 0.061777162182223 no 293 0.0300538586911922 230 5280373 A possible chelator.
SGTC_764 1951-2361 146 µM 1.87604871754258 0.0621728369545123 no 294 0.0303242952813496 268 5438930
SGTC_2387 9077560 195.08 µM 1.87402294330362 0.0623763233223179 no 295 0.0304636314455632 257 5303272
SGTC_155 k072-0202 43.6 µM 1.87324145010859 0.0624549619685274 no 296 0.0305175254463286 222 5857737
SGTC_1660 st012960 28.1 µM 1.87260980957697 0.0625185779887503 no 297 0.0305611428725404 286 24207266
SGTC_1873 rapamycin 2 nM 1.87200822661286 0.0625792137026836 no 298 0.0306027326926979 330 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2624 nerol 100 µM 1.87050470026486 0.0627309600066892 no 299 0.0307068824516376 210 637566 A natural product oil.
SGTC_65 0798-0905 34.986 µM 1.86945566877989 0.0628370052650735 no 300 0.0307797228889262 403 3602145
SGTC_490 phenamil 164 µM 1.86521428667585 0.0632671857839641 no 301 0.031075686891621 145 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2714 st079313 56.9 µM 1.86094081068341 0.0637029369203413 no 302 0.0313762678697805 235 2939799
SGTC_2558 carylophyllene oxide 100 µM 1.85839227319448 0.0639639114790266 no 303 0.0315566643774015 258 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1944 st076371 56.9 µM 1.854537105522 0.0643602662583624 no 304 0.0318311783578478 269 24208455
SGTC_2219 9098279 200 µM 1.84948469613715 0.0648825974179029 no 305 0.0321939278084862 241 902349
SGTC_2192 5915882 198.485 µM 1.8433780291461 0.0655183063577562 no 306 0.0326369178209639 209 2876149
SGTC_3325 9138760 55.175 µM 1.83814952405434 0.0660664269452691 no 307 0.0330201876400343 273 43844959
SGTC_2083 5306046 65.942 µM 1.83223364056359 0.0666908840249087 no 308 0.0334583094504173 316 539837
SGTC_3247 9135149 49.47 µM 1.83163295723937 0.0667545443523731 no 309 0.033503061604402 219 8934436 YOR116C RPO31
SGTC_720 r052-1644 49.9 µM 1.83021577429421 0.0669049235150472 no 310 0.0336088399669571 240 1422863 YOR257W CDC31
SGTC_857 0438-0306 1.35 µM 1.82899820768283 0.0670343303010567 no 311 0.0336999383728908 260 4686136
SGTC_3216 9129716 49.47 µM 1.82592594351454 0.0673617206277472 no 312 0.0339307088592128 252 8056934
SGTC_1776 st049249 45.9 µM 1.82120164642905 0.0678675666237536 no 313 0.0342881051541721 301 1822314
SGTC_805 3852-0218 479 µM 1.81358948126816 0.0686887911330835 no 314 0.0348704755328329 309 6615355
SGTC_1059 3448-6867 171 µM 1.81097486328495 0.0689726256997937 no 315 0.0350723714010496 267 3934407
SGTC_3199 9111318 49.47 µM 1.80424887581471 0.0697069311862567 no 316 0.0355961501889991 285 8548020
SGTC_976 1348-1067 47.6 µM 1.80401819216904 0.0697322222572452 no 317 0.0356142275402064 313 5310671 YGL099W LSG1
SGTC_1829 berberine 14.4 µM 1.79925066670942 0.0702564942375699 no 318 0.0359895190047289 265 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_299 1273-0059 1.44 µM 1.79840506682512 0.0703497982813285 no 319 0.0360564202100683 254 2848077
SGTC_1432 4049-0298 68.4 µM 1.79819089930341 0.0703734447806985 no 320 0.036073380626327 242 741646
SGTC_1729 st035615 45.989 µM 1.79685924494671 0.0705206115338171 no 321 0.0361789840471231 297 17385451
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.79647567226123 0.0705630456283429 no 322 0.036209449204112 380 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_5 0352-0601 109.883 µM 1.79609744810841 0.0706049072372997 no 323 0.0362395101182309 208 762456
SGTC_880 0833-0487 87.2 µM 1.79471264534213 0.0707583392191456 no 324 0.0363497473840651 277 76075
SGTC_2133 5320837 200 µM 1.79242922200296 0.0710118949942948 no 325 0.0365321186736727 283 2841355
SGTC_2541 muurolladie-3-one 83.07 µM 1.79133713233642 0.0711334091767506 no 326 0.0366196054086409 288 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_942 3253-1115 227 µM 1.79127209438335 0.0711406508272467 no 327 0.0366248209680452 297 46497897
SGTC_1046 2001-0062 216 µM 1.79094605877358 0.0711769617924249 no 328 0.0366509757547647 295 739778
SGTC_1094 duloxetine 25.4 µM 1.79030518088035 0.071248378584739 no 329 0.0367024319256194 296 60834 A selective serotonin reuptake inhibitor.
SGTC_3146 9095609 49.47 µM 1.79025488980444 0.071253985142088 no 330 0.0367064723018281 271 17173999
SGTC_2842 9000675 19.48 µM 1.79020705424354 0.0712593182676327 no 331 0.0367103157399694 289 2989072
SGTC_3286 9117135 37.221 µM 1.78821773264654 0.0714813766575722 no 332 0.0368704432265196 295 3438150
SGTC_198 3454-2873 16.191 µM 1.78781475673841 0.071526423529059 no 333 0.0369029496337309 276 710957
SGTC_806 3966-4455 5.86 µM 1.78705299158771 0.071611637348311 no 334 0.0369644621025702 257 714982
SGTC_827 3253-0474 693 µM 1.78479491680757 0.0718646914669784 no 335 0.037147294086207 303 5402065
SGTC_2884 9058502 51.95 µM 1.78327543120006 0.0720353602325115 no 336 0.0372707393767293 314 6471554
SGTC_302 1094-0063 18.9 µM 1.77755890226131 0.0726802258143174 no 337 0.0377381643490454 227 5440289
SGTC_2257 7960413 200 µM 1.77338408360209 0.0731539618663365 no 338 0.0380825422901 327 2974689 YIL048W NEO1
SGTC_2462 5162487 171.77 µM 1.76952492795638 0.0735939763206601 no 339 0.0384031572670377 282 2259986
SGTC_1815 st051655 58.2 µM 1.7681407863659 0.0737522859201258 no 340 0.0385186851873033 239 5984156
SGTC_3240 9133527 49.47 µM 1.76689327724485 0.0738951912444679 no 341 0.0386230515591414 267 17617455
SGTC_1361 1608-0041 5.61 µM 1.76255847901122 0.0743933986903983 no 342 0.0389874925888216 302 X1361
SGTC_1531 st059297 52.4 µM 1.75841458267435 0.0748720591448289 no 343 0.0393384968363431 301 7566702
SGTC_487 nimodipine 119 µM 1.7560260945432 0.0751490182036304 no 344 0.0395419765204542 189 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2973 9094665 17.96 µM 1.75593605244624 0.0751594743665599 no 345 0.0395496640848303 359 25237061 YIL048W NEO1
SGTC_2702 st077768 96.8 µM 1.75097135410875 0.0757377197757731 no 346 0.0399754222379958 291 6484119
SGTC_1158 4092-0494 91.8 µM 1.7501326733234 0.0758357357993321 no 347 0.0400477114939626 308 1148199
SGTC_2736 butenafine 14.65 µM 1.74901824781769 0.0759661273449663 no 348 0.040143932600562 350 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2571 chrysanthemic acid 100 µM 1.74801910246059 0.0760831757932084 no 349 0.0402303598527042 276 2743 An insecticide.
SGTC_1904 st060225 78 µM 1.74739849139373 0.0761559485846658 no 350 0.0402841194961958 291 66595
SGTC_1681 tripelennamine 100 µM 1.74404318248315 0.0765503096168528 no 351 0.0405757801339344 256 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2463 5473429 200 µM 1.74374709677581 0.0765851840383387 no 352 0.0406015995123007 272 5399405
SGTC_3175 9106517 49.47 µM 1.74263997214147 0.0767156936659934 no 353 0.0406982615971886 268 41468073
SGTC_2258 7960471 200 µM 1.7418637732522 0.0768072940375729 no 354 0.0407661421450852 224 2974708
SGTC_2824 7998404 51.95 µM 1.74170589873725 0.0768259352138301 no 355 0.0407799599057551 288 837851
SGTC_2700 st077718 96.8 µM 1.73833539283007 0.0772247318303116 no 356 0.0410758667340839 260 904970
SGTC_1487 3970-0795 2.82 µM 1.73807174606158 0.0772559925887555 no 357 0.0410990863133657 309 3765103
SGTC_1912 st060209 90.8 µM 1.73645459679949 0.0774479493341151 no 358 0.0412417428909641 309 688787
SGTC_3249 9135183 49.47 µM 1.73459937900521 0.0776686108723976 no 359 0.0414058947829664 318 4902779
SGTC_1848 st056003 16.4 µM 1.72674650551287 0.0786079283494448 no 360 0.0421065997827201 311 146492
SGTC_2606 farnesol 9.78 µM 1.7167660596781 0.0798141283123769 no 361 0.0430109623163172 331 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1969 st069479 40.1 µM 1.71643659429935 0.0798541836466762 no 362 0.0430410818130493 281 3895485
SGTC_175 3793-3120 23.7 µM 1.71159067887725 0.0804450919335358 no 363 0.0434860636376614 303 5322297
SGTC_3035 9091303 49.47 µM 1.70364609237085 0.0814209893265734 no 364 0.0442236124432648 260 25237002
SGTC_2272 7805186 180 µM 1.70303287511467 0.0814966853312831 no 365 0.0442809581560742 287 2956062 YPR165W RHO1
SGTC_2920 7982904 15.77 µM 1.7025372474918 0.0815579047538778 no 366 0.0443273511237099 300 6456808
SGTC_804 1595-0054 20.9 µM 1.69869408929415 0.0820337852167737 no 367 0.0446884188543653 315 761523 Stimulates phospholipase C.
SGTC_902 1120-0002 2.07 µM 1.69528825004883 0.0824572603534223 no 368 0.0450103763459032 387 3280475
SGTC_2829 7992743 58.44 µM 1.69374281308761 0.0826499588157722 no 369 0.0451570825802951 356 16462845
SGTC_3356 9151811 4.48 µM 1.69165528597694 0.082910787615921 no 370 0.0453558593059336 327 1859254 YPR165W RHO1
SGTC_168 3970-0862 530.542 µM 1.68688916255583 0.0835086172579526 no 371 0.045812333172454 562 3135186
SGTC_2024 5144227 134 µM 1.68595137030778 0.0836266279139116 no 372 0.0459025831471986 365 3475211
SGTC_1493 4348-0038 111 µM 1.68531532839514 0.0837067379495621 no 373 0.0459638749471689 361 800424
SGTC_3213 9129884 49.47 µM 1.68447855132438 0.0838122185507578 no 374 0.0460446106073387 286 17190742
SGTC_356 1634-0012 32.5 µM 1.68435934466746 0.0838272533616978 no 375 0.0460561214159294 359 735457
SGTC_633 0437-0093 97.7 µM 1.67906179449568 0.0844974482728373 no 376 0.0465700005784931 307 2831118
SGTC_1960 st011366 51.8 µM 1.67058465526865 0.0855782449048614 no 377 0.0474018727348087 278 3972846
SGTC_1345 1488-0192 31.4 µM 1.65535977156476 0.0875452863150373 no 378 0.0489257705454066 349 658348
SGTC_1647 st011722 22.4 µM 1.6552605341306 0.0875582174594147 no 379 0.0489358303819864 313 2854783
SGTC_540 1187-0821 17.3 µM 1.65385543560341 0.0877414619625644 no 380 0.0490784446062661 329 847520
SGTC_20 0481-0013 4.944 µM 1.65026702293845 0.088210739227916 no 381 0.0494441669680152 347 182045
SGTC_631 k072-0230 41.5 µM 1.64371471586865 0.0890724446011534 no 382 0.0501175723907184 367 5773147
SGTC_226 1,3-diallylurea 8.28947 mM 1.63853971821184 0.089757433674599 no 383 0.050654577844438 297 74537 YKL182W FAS1
SGTC_2804 7954240 19.48 µM 1.63716819480903 0.0899396302563416 no 384 0.0507976653229591 379 828705
SGTC_1143 3454-2408 5.08 µM 1.63685268974878 0.0899815815914326 no 385 0.050830626637936 268 X1143
SGTC_1236 0330-0013 258 µM 1.63360096929729 0.0904147962146414 no 386 0.0511713320866514 313 4617066
SGTC_2656 pseudo-anisatin 100 µM 1.63347940695811 0.0904310214914409 no 387 0.0511841041713388 262 6708809 A neurotoxin.
SGTC_1233 0325-0408 14.2 µM 1.63322464816892 0.0904650318963699 no 388 0.0512108789197821 350 12874
SGTC_547 1120-0019 610 nM 1.62777266729577 0.0911951516615082 no 389 0.0517865490862556 354 3676939
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.62135080968154 0.0920607494909606 no 390 0.0524712119622331 387 688667
SGTC_1162 k048-0130 20.1 µM 1.61925071749301 0.0923451353194226 no 391 0.0526966648030165 354 6797406
SGTC_3122 9126309 49.47 µM 1.61758282724185 0.092571456942664 no 392 0.0528762662143488 315 17591206
SGTC_3290 9121031 71.43 µM 1.61420070491146 0.0930316476325926 no 393 0.0532419495788522 317 17014854
SGTC_3177 9107506 49.47 µM 1.60814044409757 0.0938604669043781 no 394 0.053902211572007 283 8897194
SGTC_2866 9034245 58.44 µM 1.6029563341519 0.0945737756879326 no 395 0.0544721474530681 307 6462273
SGTC_821 1114-0266 29.2 µM 1.59919116054047 0.095094345281917 no 396 0.0548890669162058 350 3123235
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.59870496714178 0.0951617195089549 no 397 0.0549430867089182 314 6857784
SGTC_1137 ixabepilone 100 µM 1.59806040267958 0.0952510941837166 no 398 0.055014767494367 403 154225 A novel microtubule stabilizer.
SGTC_1380 2291-0730 164 µM 1.59485489463728 0.095696484878458 no 399 0.0553723440533431 357 2999191
SGTC_2775 cyproheptadine 69.59 µM 1.59420810299301 0.0957865391024721 no 400 0.055444716116171 358 2913 A selective serotonin reuptake inhibitor.
SGTC_3047 9092122 49.47 µM 1.59418849300242 0.0957892704179827 no 401 0.0554469115211284 367 17173831
SGTC_1888 azatryptophan 97.5 µM 1.59216259505051 0.0960717499893261 no 402 0.0556740877118739 312 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2719 novobiocin 32.65 µM 1.58737287362564 0.0967420361550486 no 403 0.0562141096329292 257 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1732 st034308 51.822 µM 1.58524333957115 0.0970411492080014 no 404 0.0564555285162508 389 830119
SGTC_3057 9095946 49.47 µM 1.57943911795854 0.0978598521860575 no 405 0.0571176853862299 349 24540043
SGTC_3194 9111903 49.47 µM 1.57628931078928 0.0983062556199384 no 406 0.0574795719695304 387 17087251
SGTC_340 k038-0059 454 µM 1.574413072173 0.0985728715541865 no 407 0.0576959918282941 407 23733424
SGTC_2098 5376439 882.5 nM 1.56211850845263 0.100333053493576 no 408 0.0591300367313016 411 2844116
SGTC_2420 aureobasidin a 50 nM 1.56039480807842 0.100581653400442 no 409 0.0593333055041552 447 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2253 7938677 135.83 µM 1.55622745392772 0.101184543969351 no 410 0.0598270076180716 367 2301972
SGTC_219 mitoxanthrone 164.414 µM 1.55617518094148 0.10119212298226 no 411 0.0598332207177779 403 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_542 3381-0244 89.3 µM 1.55500247639945 0.101362261108078 no 412 0.0599727397719255 449 1112843
SGTC_1313 1220-0047 237 µM 1.55398845314642 0.101509545385392 no 413 0.0600935854771385 446 3528706
SGTC_2511 berberine 10.47 µM 1.55291612671241 0.101665467551422 no 414 0.0602215867656764 356 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1999 st074831 12.5 µM 1.55212686574873 0.101780341799813 no 415 0.0603159354213935 419 17112523
SGTC_2593 nobiletin 86.24 µM 1.54484723921406 0.102844323974421 no 416 0.0611916089323253 351 72344 An anti-infammatory.
SGTC_483 fpl-64176 144 µM 1.54177380967733 0.10329595113945 no 417 0.0615642842778229 304 3423
SGTC_1240 0356-0016 42.1 µM 1.53947406110462 0.103634829838678 no 418 0.0618443028118849 405 4305613
SGTC_1574 spiramycin 23.7 µM 1.52911444677673 0.10517137022692 no 419 0.0631180372676986 424 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2727 riluzole 51.77 µM 1.52619990214101 0.105606612779635 no 420 0.0634800439206371 352 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_262 fenpropimorph 62.5 µM 1.52020761501353 0.106505557540442 no 421 0.0642294020700753 371 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2342 7990637 118.86 µM 1.51848896392292 0.106764400881262 no 422 0.0644455897735625 436 2033102 YER133W GLC7
SGTC_2267 7931562 200 µM 1.51826812640443 0.106797693757695 no 423 0.06447340968455 383 934880
SGTC_2414 st077232 92.9 µM 1.51660725383942 0.107048322539384 no 424 0.0646829364373695 411 729801
SGTC_740 k014-0057 261 µM 1.51639539661212 0.107080322674276 no 425 0.0647097011928014 457 4012779
SGTC_527 4476-4215 268 µM 1.51336033564756 0.107539513320956 no 426 0.0650940772079515 426 4418754
SGTC_638 3970-0837 4.09 µM 1.51226214262732 0.107706013955109 no 427 0.0652335938662014 423 4118451 YLR208W SEC13
SGTC_2235 salicylic acid 500 µM 1.51190668428883 0.107759945919752 no 428 0.0652788016774847 357 338 A COX inhibitor and kinase inhibitor.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.51069834581018 0.10794342669967 no 429 0.0654326620371626 391 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_825 1988-2224 89.6 µM 1.50433622211616 0.10891319775422 no 430 0.0662474084762111 450 1180859
SGTC_1201 1889-3372 45.9 µM 1.50433035113502 0.108914095544184 no 431 0.0662481639379919 372 5392199
SGTC_2014 4013930 200 µM 1.50171984300965 0.109313821509575 no 432 0.0665847385211938 475 64556
SGTC_2528 xanthyletin 44.79 µM 1.50057002987565 0.10949021700679 no 433 0.0667334039284169 380 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_925 2064-1272 59.6 µM 1.49782450808407 0.109912240451871 no 434 0.0670894257611467 401 6815817
SGTC_1480 1070-0044 41.2 µM 1.49512388537423 0.110328499919424 no 435 0.0674410566419741 419 3124987
SGTC_1106 tegaserod maleate 11.7 µM 1.49323011352973 0.110621069257699 no 436 0.0676884810225695 451 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2764 methyldopa 94.69 µM 1.49296155465995 0.110662603969571 no 437 0.0677236253783387 448 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_477 mead ethanolamide 10 µM 1.49085821220992 0.110988288775996 no 438 0.0679993622765906 246 16061185
SGTC_1897 st060201 15 µM 1.48986796916032 0.111141857012398 no 439 0.0681294775613481 389 611878
SGTC_2232 chlorophetanol 41.5365 µM 1.48725022681276 0.111548552643047 no 440 0.0684743674648129 575 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_157 1348-1695 65.819 µM 1.48721279433634 0.111554375910387 no 441 0.0684793089768512 516 5380510
SGTC_492 tmb-8 126 µM 1.48678991643671 0.111620176971119 no 442 0.0685351527733152 257 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2825 7998094 58.44 µM 1.48575160782797 0.111781858668878 no 443 0.0686724172377557 414 2987815
SGTC_1826 st055655 41.6 µM 1.48517534800585 0.111871664033257 no 444 0.0687486902561436 442 676168
SGTC_590 k048-0076 22.4 µM 1.48424256324344 0.112017140218749 no 445 0.0688722908870145 423 6832814
SGTC_2308 7584454 197.62 µM 1.47966686535729 0.112732720579051 no 446 0.0694810862148882 485 893577
SGTC_2051 5263410 176 µM 1.47360062674477 0.113686426154112 no 447 0.0702945762606839 433 227584
SGTC_2601 securinine 100 µM 1.46958432526538 0.114321006353817 no 448 0.0708371840581076 420 442872 A GABA receptor antagonist.
SGTC_2676 harmalol 100 µM 1.4694131297595 0.114348111370857 no 449 0.070860384107921 443 5459187 A monoamine oxidase inhibitor
SGTC_1963 st076565 50.3 µM 1.46816101930403 0.114546494455238 no 450 0.0710302449589006 436 4914280
SGTC_2445 5742597 35.57 µM 1.46493761368699 0.115058334237348 no 451 0.071468969716597 430 1774255
SGTC_875 0709-0210 25.7 µM 1.46356746915939 0.115276389299326 no 452 0.0716560832029378 491 6251364
SGTC_2359 9039622 200 µM 1.46052409999184 0.115761784345492 no 453 0.0720730445093953 446 6463596
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.45717560089415 0.11629752055513 no 454 0.0725339569285053 451 5282309
SGTC_1179 1021-1431 9.29 µM 1.45592560980223 0.116497960528868 no 455 0.0727065925968733 527 2840958
SGTC_842 0271-0008 11.1 µM 1.45579481315656 0.116518948331766 no 456 0.0727246750275105 479 1221709
SGTC_258 haloperidol 50.781 µM 1.45548085746736 0.116569337020984 no 457 0.0727680929612853 466 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2418 pentamidine 31.67 µM 1.45482890162142 0.116674022805295 no 458 0.0728583174120882 433 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_232 clozapine 119 µM 1.44650405396742 0.118016622210612 no 459 0.0740179378895128 444 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_31 0508-1974 57.237 µM 1.44569839234595 0.11814713386318 no 460 0.0741309077376406 462 6810525
SGTC_670 4204-0025 119 µM 1.44473912344488 0.118302661914318 no 461 0.0742655881037137 481 719039
SGTC_3028 9087778 49.47 µM 1.44442805766268 0.118353126653635 no 462 0.0743093015173972 425 17217395
SGTC_2170 morpholine 200 µM 1.44228387763112 0.11870139468527 no 463 0.0746111532479108 415 121171 Reacts with secondary amines.
SGTC_2072 5231554 129 µM 1.43949942474735 0.119154738653051 no 464 0.0750045364167517 443 789545
SGTC_2357 9067248 200 µM 1.43775541750124 0.119439306728251 no 465 0.0752517315241442 421 9150235
SGTC_2569 tetrandrine 100 µM 1.4375505646516 0.119472763824384 no 466 0.0752808080251408 411 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1398 3558-0053 112 µM 1.43644434865826 0.119653548133685 no 467 0.0754379706554796 375 4532369
SGTC_1673 st016611 27.3 µM 1.43016083469544 0.120684097405848 no 468 0.07633543168014 487 5226799
SGTC_1363 1636-0063 10.4 µM 1.43001047195527 0.120708834479215 no 469 0.0763570067747572 487 6072185
SGTC_1112 tnp00069 1.16933 µM 1.4276231012608 0.121102073408721 no 470 0.0767001853436767 516 145826
SGTC_1445 4239-0156 97.7 µM 1.42629640919089 0.121320990388093 no 471 0.0768914003397472 526 4008346
SGTC_1505 k297-0037 20.6 µM 1.42427291881849 0.121655421433767 no 472 0.0771837418464689 490 4089396
SGTC_3266 9136860 49.47 µM 1.42156284334484 0.122104341499884 no 473 0.07757659893203 477 4871271 YPR165W RHO1
SGTC_652 0437-0092 114 µM 1.42117132053079 0.122169292724582 no 474 0.0776334800289257 420 3091274
SGTC_412 gemfibrozil 100 µM 1.42108523207467 0.122183577522183 no 475 0.0776459913510638 385 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_369 0957-0393 4.5 µM 1.42077945302322 0.122234325417489 no 476 0.0776904429039429 438 6997992
SGTC_2368 9071271 200 µM 1.42036851794252 0.122302548586149 no 477 0.0777502115671745 464 27209959
SGTC_1928 4'-methoxychalcone 40.3 µM 1.41610559816019 0.123011852723401 no 478 0.0783722946488191 464 641818
SGTC_2841 9004761 38.96 µM 1.41435455860766 0.12330404088382 no 479 0.0786289126052696 427 2991039
SGTC_974 1326-0144 138 µM 1.41365373504636 0.12342112033942 no 480 0.0787317978031841 500 5411856
SGTC_1893 st059353 36.1 µM 1.4121476371737 0.123672992226596 no 481 0.0789532473494153 489 3112488
SGTC_200 k038-0079 37.545 µM 1.4106943591723 0.123916371784128 no 482 0.0791673774788259 454 3436683
SGTC_307 1501-1223 22.3 µM 1.40838984388 0.124302994403384 no 483 0.079507832447126 469 2830329
SGTC_2765 myclobutanil 7.74 µM 1.40590080475247 0.124721520948871 no 484 0.0798767911643498 493 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1316 1272-0050 65.9 µM 1.40579699625553 0.124738997490962 no 485 0.0798922071303841 462 7340392
SGTC_2339 9000433 200 µM 1.40019329720211 0.125684941489692 no 486 0.0807277212494835 441 2988954
SGTC_2298 7976326 193.81 µM 1.3977347791659 0.126101532224292 no 487 0.0810963630863459 397 2235818
SGTC_2436 5633522 8.09 µM 1.39773311941497 0.126101813790376 no 488 0.0810966123856494 508 5724242
SGTC_1560 lithocholic acid 53.1 µM 1.3885928754545 0.127659049028067 no 489 0.0824782925237086 366 9903 A bile acid which acts as a detergent.
SGTC_3272 9137413 49.47 µM 1.3863195335562 0.128048428397597 no 490 0.0828246774069123 469 17614870
SGTC_2830 7992007 71.43 µM 1.3859210988292 0.12811675741811 no 491 0.0828854987275257 464 1952075
SGTC_2200 6600604 21.907 µM 1.38571859177388 0.128151495794911 no 492 0.0829164244374261 515 2904777
SGTC_1714 st033236 13.627 µM 1.38425707449646 0.128402400736033 no 493 0.0831398763658869 519 2916566
SGTC_1607 st000305 50.6 µM 1.38258254010177 0.128690294203964 no 494 0.0833964528552373 500 5457690
SGTC_2189 6047310 154.431 µM 1.38009511869824 0.12911876910875 no 495 0.0837786800154327 461 711535
SGTC_2855 9016525 58.44 µM 1.37763261244924 0.129543925491704 no 496 0.0841583733168593 481 43811474
SGTC_1661 st013063 9.66 µM 1.37738769760032 0.12958626347004 no 497 0.0841962071950672 541 721395
SGTC_2745 rifampicin 24.3 µM 1.37647775457223 0.129743647600919 no 498 0.0843368849181899 331 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3114 9122766 49.47 µM 1.37307316721166 0.130333680406293 no 499 0.0848648008957441 472 17176985
SGTC_2673 kobusone 100 µM 1.37195570172642 0.130527747011468 no 500 0.0850386142447667 460 6710676 An epoxy ketone and protein crosslinker.
SGTC_866 0495-0101 262 µM 1.37026681269019 0.130821429958599 no 501 0.0853018143892214 480 635694
SGTC_493 zm226600 134 µM 1.36993252629743 0.130879613523643 no 502 0.0853539825836799 508 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3234 9132280 49.47 µM 1.3691418442731 0.131017305305906 no 503 0.0854774702562224 521 17612295
SGTC_2882 9058044 58.44 µM 1.3683130014595 0.131161749936009 no 504 0.0856070614251036 462 18076804
SGTC_3273 9137859 49.47 µM 1.36220220752435 0.132230089115763 no 505 0.0865670396786816 453 2377234
SGTC_35 0133-0054 64.071 µM 1.36170578720818 0.132317140095277 no 506 0.0866453770763779 484 99677
SGTC_881 0833-0569 170 µM 1.35563192186579 0.133385436095601 no 507 0.0876081549408928 515 5418700
SGTC_2800 7887935 81.82 µM 1.35532304882199 0.133439920020173 no 508 0.0876573273263371 492 2961002
SGTC_2177 5811945 192 µM 1.35434296743806 0.133612903654978 no 509 0.0878134919722687 505 5343475
SGTC_76 0433-0009 400.328 µM 1.35094188312377 0.134214388170358 no 510 0.0883570251107423 428 2841569
SGTC_2195 6536160 144.242 µM 1.35020349100521 0.134345218749728 no 511 0.0884753593555597 437 3834386
SGTC_3321 9137793 26.8275 µM 1.34862708437658 0.134624824295061 no 512 0.0887283883267229 538 4904192
SGTC_1323 1348-1351 11.2 µM 1.34492044617265 0.135283839515237 no 513 0.0893254633338394 480 6989654
SGTC_2356 9061756 188.97 µM 1.34446499810998 0.13536496739969 no 514 0.0893990338171124 469 20104043
SGTC_148 3253-0744 288.01 µM 1.34166317634616 0.135864782766892 no 515 0.0898526159096252 493 6893655
SGTC_482 fipronil 114 µM 1.33920873541078 0.136303666264999 no 516 0.0902513647238198 432 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_107 0358-0022 2.6945 µM 1.33873382194161 0.136388698371581 no 517 0.0903286707606717 366 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2064 5220758 200 µM 1.33801688068846 0.13651713369681 no 518 0.0904454670261507 567 788518
SGTC_397 arbidol 50 µM 1.3364271096284 0.136802225763945 no 519 0.0907048551571112 543 131410 A RNA synthesis inhibitor.
SGTC_559 1550-0661 158 µM 1.33322437254419 0.137377804530926 no 520 0.0912290916911935 515 5830875
SGTC_464 bw-b 70c 158 µM 1.33250714845311 0.13750692649967 no 521 0.0913467970152444 562 5353454
SGTC_1208 2323-2347 50.3 µM 1.32680944529656 0.13853562816875 no 522 0.0922858626074496 523 5412760
SGTC_1039 k821-0043 94 µM 1.32492258710871 0.138877447095211 no 523 0.0925984142223249 533 15992768
SGTC_1390 3413-2614 145 µM 1.32459309930897 0.13893719520248 no 524 0.0926530729621418 555 3421432
SGTC_2391 6285546 200 µM 1.32324304934747 0.139182191058555 no 525 0.0928772820107727 546 846083
SGTC_2622 2-methoxyxanthone 59.94 µM 1.32133473658668 0.139528997054497 no 526 0.0931948882523356 546 71034 A hepatoprotective.
SGTC_1983 st071813 46.9 µM 1.32083148906713 0.139620552267458 no 527 0.0932787788310071 531 11838595
SGTC_306 1672-3436 11.6 µM 1.31950403622741 0.139862250122605 no 528 0.0935003308227007 546 6797378
SGTC_81 0411-0046 9.971 µM 1.31946537465017 0.139869293743358 no 529 0.093506789262642 488 12925265
SGTC_924 2046-0044 21.3 µM 1.31781618449934 0.140169978576447 no 530 0.0937825943542622 528 3623589
SGTC_1525 8-methoxypsoralen 92.5 µM 1.31747410788092 0.140232401859911 no 531 0.0938398772369244 591 4114 Related to psoralen; DNA damaging agent.
SGTC_2194 5927483 104.545 µM 1.31625245362646 0.14045548751946 no 532 0.0940446617412627 573 760979
SGTC_2197 6588183 93.1375 µM 1.31531984126419 0.140625953482747 no 533 0.0942012162957773 475 884136
SGTC_2465 5809242 33.21 µM 1.31453103827499 0.140770243061236 no 534 0.0943337800405615 494 2731748
SGTC_2769 toremifene 3.73 µM 1.31448230790788 0.140779160220713 no 535 0.0943419740223817 502 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2643 anethole 100 µM 1.3138324753971 0.140898109567546 no 536 0.0944512931420839 555 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_603 3794-0023 45.9 µM 1.31336895553295 0.140982996748397 no 537 0.0945293265697251 506 3802260
SGTC_84 0443-0269 128.823 µM 1.30858187348655 0.1418617128861 no 538 0.0953380121691977 544 6150058
SGTC_2037 5169046 200 µM 1.30715564352114 0.142124226999312 no 539 0.0955799282847995 508 5718022
SGTC_834 0312-0008 75.7 µM 1.30706217526213 0.142141442385023 no 540 0.0955957980623798 577 6385573 YIL048W NEO1
SGTC_3096 9117468 49.47 µM 1.30497803261659 0.142525675331566 no 541 0.0959501640303882 416 41316311
SGTC_2325 6158266 200 µM 1.30484962310067 0.142549371886376 no 542 0.0959720290026928 531 3623240
SGTC_419 nsc-638432 893 µM 1.30464529384226 0.142587084082054 no 543 0.09600682878765 547 368090
SGTC_141 0443-0274 32.331 µM 1.30215566622284 0.143047126133795 no 544 0.0964315885183148 670 1627241
SGTC_2665 lovastatin 100 µM 1.3019631743017 0.143082737179653 no 545 0.0964644873216945 529 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1073 triclabendazole 3.09 µM 1.2981325047798 0.143792657466117 no 546 0.0971209032158123 616 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1183 1254-0324 198 µM 1.29747565387621 0.14391462688912 no 547 0.0972337883536562 558 5799357
SGTC_2827 7993847 71.43 µM 1.2958816688647 0.144210901090599 no 548 0.0975081278068127 492 2985692
SGTC_2940 9060638 45.86 µM 1.29318311344684 0.144713418675931 no 549 0.0979738673205157 557 4027022
SGTC_1524 corynanthine 62.1 µM 1.28818845175798 0.145646619112331 no 550 0.098840185473293 520 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2148 5546263 113.568 µM 1.28729384688267 0.1458141929938 no 551 0.0989959437030206 531 792097
SGTC_1229 0139-0193 12.2 µM 1.28301923165008 0.146616685584252 no 552 0.0997426692203647 595 3090752
SGTC_3123 9126162 49.47 µM 1.28041221748421 0.147107564342427 no 553 0.100200099691372 542 25239884
SGTC_2266 7929956 200 µM 1.27677245598483 0.147794741856078 no 554 0.100841296261617 586 2967153
SGTC_259 usnic acid 108.925 µM 1.27577280673412 0.14798384865942 no 555 0.101017921474513 577 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1774 st048371 48.465 µM 1.27551703074441 0.148032260620759 no 556 0.101063150023869 585 4242727
SGTC_2889 9059656 51.95 µM 1.27475126761189 0.148177263687681 no 557 0.101198647203875 590 3949838
SGTC_1248 0469-0687 58.6 µM 1.27333339835691 0.148445998819204 no 558 0.101449880025375 588 4017482
SGTC_176 1486-1328 72.834 µM 1.2723616693057 0.148630363115934 no 559 0.10162232325535 599 22310231
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.27208605110949 0.148682683484201 no 560 0.101671273347644 555 4330530
SGTC_1754 st042065 16.137 µM 1.26845239472762 0.149373608418096 no 561 0.102318220456614 713 1126236 YIL048W NEO1
SGTC_798 1287-0182 476 µM 1.26813513527541 0.149434035585894 no 562 0.102374848075509 627 1649755
SGTC_3239 9133757 49.47 µM 1.26783053280286 0.149492067379788 no 563 0.102429237992824 552 17036923
SGTC_1426 4048-4480 71.7 µM 1.26394010603792 0.15023458063922 no 564 0.103125762629412 590 14224343
SGTC_2517 totarol 10 µM 1.26350381200039 0.150318003212857 no 565 0.103204088761522 519 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1299 1079-1439 3.74 µM 1.26321782678604 0.150372702398284 no 566 0.103255453982062 555 323161
SGTC_574 1315-0397 40 µM 1.25894536818126 0.151191456513586 no 567 0.104025032698961 661 6794277
SGTC_1080 nisoldipine 24.4 µM 1.25874907414391 0.151229144514326 no 568 0.104060489923602 612 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2975 9084847 53.72 µM 1.25620930718557 0.15171733738687 no 569 0.104520046597627 591 27211724
SGTC_1516 st013856 110 µM 1.25598363869784 0.151760765891855 no 570 0.104560951067596 550 5281404 A mutagen and neurotoxin.
SGTC_2877 9040724 71.43 µM 1.25591607120688 0.151773770444488 no 571 0.104573200546679 559 6463895
SGTC_1759 st043059 70 µM 1.25283067877211 0.152368397487329 no 572 0.105133667088873 605 669426
SGTC_372 0155-0182 15.9 µM 1.25230410673139 0.152470034456038 no 573 0.105229536511861 636 771486
SGTC_2972 9093619 59.92 µM 1.24876533649681 0.15315424161668 no 574 0.105875457876899 561 25236256
SGTC_1324 1418-0026 34.4 µM 1.24762292644705 0.153375555878354 no 575 0.106084589240988 604 1372513
SGTC_765 1319-0117 244 µM 1.24733109876211 0.153432124375237 no 576 0.106138059496539 539 3487746 YGL099W LSG1
SGTC_2369 9071472 200 µM 1.24426433251957 0.154027428482327 no 577 0.106701146782415 588 17296037
SGTC_958 1222-0007 33 µM 1.24362909604166 0.154150927955403 no 578 0.106818051251502 641 7312461
SGTC_3181 9108277 49.47 µM 1.24354544167641 0.154167196494728 no 579 0.106833453298616 556 17097298
SGTC_666 0272-0154 136 µM 1.24332691122127 0.15420970018854 no 580 0.106873695655431 614 6870312
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.24267112836223 0.154337295036494 no 581 0.106994523640306 574 115019
SGTC_2784 7567673 72.73 µM 1.2412451873008 0.154614979457014 no 582 0.107257593269935 622 3471247
SGTC_2003 4023581 200 µM 1.23845892448212 0.155158522076472 no 583 0.107772971761446 577 16641307
SGTC_1221 2958-7315 257 µM 1.23471439905588 0.155890986515267 no 584 0.108468407531161 587 4562705
SGTC_1985 st071382 65.5 µM 1.23394566672509 0.156041639359633 no 585 0.108611575564561 592 6123237
SGTC_1430 4049-0248 69.1 µM 1.23299050143569 0.156228962163004 no 586 0.108789654005527 658 22774488
SGTC_1154 4088-0362 150 µM 1.232883846189 0.156249888110469 no 587 0.108809551544788 667 6618304
SGTC_2476 5806916 10.51 µM 1.23095925071476 0.156627814411498 no 588 0.10916905265929 575 2870194
SGTC_2627 acetyl isogambogic acid 100 µM 1.22525146573475 0.157752168536702 no 589 0.110240244394834 570 6857789 A caspase activator and apoptosis inducer.
SGTC_2533 agelasine 13.65 µM 1.22523631818627 0.157755159428648 no 590 0.110243097160326 646 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2845 9003024 42.97 µM 1.21956426838982 0.158877727075265 no 591 0.111315049346684 620 2990173
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.21854036474072 0.159080926533571 no 592 0.111509347707748 537 17037758
SGTC_617 3770-0098 35 µM 1.216802996104 0.159426106524043 no 593 0.111839589911717 572 5962639
SGTC_2132 5317594 122.667 µM 1.21639790196057 0.15950666097585 no 594 0.111916691404097 543 794577
SGTC_1127 asiatic acid 681.4 nM 1.2163406178565 0.15951805427923 no 595 0.111927597343585 590 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.21620748839375 0.159544534613421 no 596 0.111952945911599 642 2724 A muscle relaxant with antifungal properties.
SGTC_2718 lomofungin 53.02 µM 1.21618570182311 0.159548868380934 no 597 0.111957094583015 579 5351222 A RNA synthesis inhibitor.
SGTC_91 0417-1751 58.384 µM 1.21539273488868 0.159706657178571 no 598 0.112108168810918 729 6795624
SGTC_1572 epiandrosterone 68.9 µM 1.21503387439221 0.159778098706497 no 599 0.112176585959618 645 441302 A steroid.
SGTC_1739 st037196 92.5 µM 1.21382612018543 0.160018690570192 no 600 0.112407064849238 651 612214
SGTC_414 piperonyl butoxide 100 µM 1.2116437472191 0.160454032806701 no 601 0.112824390406869 602 5794 A potent inhibitor of cytochrome P450.
SGTC_1966 st070145 16.1 µM 1.20973365177569 0.160835695251912 no 602 0.11319055629033 604 3748532
SGTC_190 3970-0790 3.722 µM 1.20739362308006 0.161304071231425 no 603 0.11364029510859 576 2832352
SGTC_966 1300-0360 30.2 µM 1.20575090149451 0.161633406429944 no 604 0.113956775996728 621 70588
SGTC_1932 st074806 40.9 µM 1.20513989630488 0.161756013385992 no 605 0.114074650157559 669 17251235
SGTC_1366 1683-0113 21.9 µM 1.20438099869787 0.161908381444376 no 606 0.114221176389913 581 708623
SGTC_637 1181-0519 7.26 µM 1.20406774646867 0.161971302077195 no 607 0.114281697486551 714 6252091 YGR060W ERG25
SGTC_2043 5101342 149 µM 1.20320504890018 0.162144668012649 no 608 0.114448490796246 612 678451
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.20250809693287 0.162284814260845 no 609 0.114583365469806 681 23847180
SGTC_2929 9013348 24.6 µM 1.20209252265639 0.162368417330242 no 610 0.114663841535121 603 2995952
SGTC_2743 auranofin 4.32 µM 1.20207768107976 0.162371403599734 no 611 0.114666716353918 586 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2239 6685329 187.64 µM 1.20177379956894 0.162432555373056 no 612 0.114725589589573 616 805680
SGTC_1133 3473-0247 50 µM 1.19974352029502 0.162841504354016 no 613 0.115119482668391 647 711311
SGTC_171 k064-0041 9.68 µM 1.19621520460703 0.163553786668375 no 614 0.115806294468339 515 53325
SGTC_721 1187-1332 279 µM 1.19501717445774 0.163796099632274 no 615 0.116040160023783 541 25730
SGTC_1701 st028638 40.4 µM 1.19314974251134 0.164174269886288 no 616 0.116405366671347 620 3490878
SGTC_6 0844-0013 19.835 µM 1.1917605226943 0.164455965294022 no 617 0.11667757956705 858 1584900
SGTC_1750 st081859 2.357 µM 1.18878150737038 0.165061082911261 no 618 0.117262828435524 796 5291695
SGTC_2137 5261020 140 µM 1.1879695209628 0.16522626873159 no 619 0.117422708973286 612 763655
SGTC_1219 1469-0211 33.1 µM 1.18561134173633 0.165706609405967 no 620 0.117887910584216 603 6822282
SGTC_2457 5731572 11.68 µM 1.18432385134062 0.165969240704742 no 621 0.118142445384166 634 2865357
SGTC_1385 3091-4834 14.1 µM 1.18230670279036 0.166381253333755 no 622 0.118542013477284 575 4072814
SGTC_143 4032-1194 15.74 µM 1.18227265934879 0.166388212538406 no 623 0.118548765177953 727 1806963
SGTC_3090 9117696 49.47 µM 1.18213550958585 0.166416250775304 no 624 0.118575968298899 610 7923821
SGTC_1790 st045711 43.5 µM 1.18212954666851 0.166417469874599 no 625 0.118577151120367 629 585119
SGTC_2484 5809818 12.04 µM 1.1802253835622 0.166807064811829 no 626 0.118955292936876 617 2870548
SGTC_901 1112-0062 60.1 µM 1.17920774864615 0.16701551567526 no 627 0.119157730680358 624 1908457
SGTC_2313 7726885 200 µM 1.17902573160982 0.167052817484254 no 628 0.119193964887191 626 726423
SGTC_672 1441-0018 53.7 µM 1.17762349302831 0.167340366478896 no 629 0.119473369869267 604 251141
SGTC_1651 st011928 86.1 µM 1.17578986280742 0.167716859451095 no 630 0.119839429126703 640 720198
SGTC_1625 st003711 30.1 µM 1.17374543902721 0.168137276567341 no 631 0.120248501983792 630 24207034 YER133W GLC7
SGTC_1627 st003713 25.6 µM 1.1706553704051 0.168774006826736 no 632 0.120868665574152 722 16195070 YER133W GLC7
SGTC_1622 st003707 19.4 µM 1.17030429121126 0.16884644704766 no 633 0.12093926780716 680 10140899
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.16831146117157 0.169258017768286 no 634 0.121340576970382 893 16725076
SGTC_2340 7987427 183.45 µM 1.16785486254766 0.169352407752104 no 635 0.121432656904945 630 2239331
SGTC_1265 0819-1001 68.8 µM 1.16392068937619 0.170167095819968 no 636 0.122228077132086 614 3106768
SGTC_2856 9022925 19.48 µM 1.16249976025905 0.170461957928347 no 637 0.122516261005974 667 4944862
SGTC_1832 st054113 55 µM 1.15970673302792 0.171042502104821 no 638 0.123084113971077 620 1251267
SGTC_2982 9019404 25.97 µM 1.15918011774285 0.171152103171881 no 639 0.123191386995537 536 22333232
SGTC_1285 0929-0069 65.5 µM 1.15796775881022 0.171404594346895 no 640 0.123438596945232 658 1206237
SGTC_2720 fluspirilene 36.88 µM 1.15742474271183 0.171517762415903 no 641 0.123549434995917 594 3396 An atypical antipsychotic.
SGTC_667 1498-1044 59 µM 1.15683796468532 0.171640104414843 no 642 0.123669283872351 690 6739982
SGTC_2095 5432005 200 µM 1.15400641412584 0.172231260200937 no 643 0.124248769639723 615 783734
SGTC_1917 st066507 28.5 µM 1.15211496702107 0.172626869177882 no 644 0.124636916788375 688 3156428
SGTC_2315 7733312 200 µM 1.15124907508439 0.172808169514737 no 645 0.12481489050047 612 726316
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.15043900609079 0.172977891482685 no 646 0.124981551181303 610 2346 DNA damaging agent; causes G2/M arrest.
SGTC_733 4069-0007 56.1 µM 1.14872151168531 0.173338084240289 no 647 0.125335416323828 733 5717425 YNL287W SEC21
SGTC_1695 st026914 34.495 µM 1.14171699192479 0.174812011689619 no 648 0.126785837755974 671 3289191
SGTC_1879 gemcitabine 100 µM 1.14093266671116 0.174977547309905 no 649 0.126948972096959 670 60750 A nucleoside analog which inhibits DNA replication.
SGTC_211 3455-0679 143.504 µM 1.14046131306231 0.175077076602275 no 650 0.127047080725305 695 748649
SGTC_2434 5670830 169.91 µM 1.13794511991185 0.175608994043948 no 651 0.12757169954694 665 1549830
SGTC_3018 9082602 49.47 µM 1.13593996443787 0.176033611707336 no 652 0.127990845511594 706 17332089
SGTC_503 tyrphostin 8 294 µM 1.13250522149645 0.176762472047061 no 653 0.128711045207632 661 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2439 5492030 7.2 µM 1.13080308493077 0.177124375284098 no 654 0.129068990615828 654 5722370
SGTC_2611 pyromycin 23.93 µM 1.12810854873572 0.177698235788852 no 655 0.129637039625323 644 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2646 retinol 96.75 µM 1.1276055331077 0.177805493777127 no 656 0.12974327444846 672 445354 A vitamin A analog and teratogen.
SGTC_844 0330-0132 15.3 µM 1.12750215102639 0.177827542989452 no 657 0.129765115783684 707 2828079
SGTC_261 5-fluorouridine 15.376 µM 1.12695505787254 0.177944255104617 no 658 0.129880741500385 690 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_61 0978-8327 98.565 µM 1.12485809079703 0.178392051176021 no 659 0.130324586782851 715 6150059 YHR072W ERG7
SGTC_253 dyclonine 31.25 µM 1.11740580944552 0.179989184073146 no 660 0.131910426161759 746 3180 An oral anasthetic.
SGTC_2475 5812728 15.03 µM 1.11627106657891 0.180233161377225 no 661 0.132153061290416 710 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2478 5763493 32.33 µM 1.11538344151037 0.18042415131087 no 662 0.132343071095804 719 1365576 YLR208W SEC13
SGTC_85 0868-0259 160.055 µM 1.11535637593677 0.18042997699372 no 663 0.132348867855123 660 83173
SGTC_501 nsc-95397 161 µM 1.11246544376914 0.181052910079928 no 664 0.132969039986993 678 262093
SGTC_2560 caryophyllene 100 µM 1.10922918454572 0.181751850071331 no 665 0.133665662776204 752 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3091 9116372 49.47 µM 1.10861172528102 0.18188539522515 no 666 0.133798858849912 641 17169793
SGTC_1898 st060199 18.6 µM 1.10472776126449 0.182726832163509 no 667 0.134638785202526 674 688866
SGTC_1126 isoteolin 1.0172 µM 1.10392938386551 0.182900096373772 no 668 0.134811885657616 682 133323
SGTC_655 k060-0012 42 µM 1.10008081055101 0.183736753095473 no 669 0.135648456974371 695 5994525
SGTC_1657 st012939 43.4 µM 1.0973838997821 0.184324463766358 no 670 0.136236804246679 665 24207257
SGTC_50 0929-0078 56.389 µM 1.09338256049037 0.185198587798745 no 671 0.137112933646475 680 1377751
SGTC_2079 5212404 121 µM 1.09263230574117 0.185362773005624 no 672 0.137277636285684 720 758462
SGTC_755 1995-0008 37.3 µM 1.09197538761651 0.185506606670974 no 673 0.137421959743334 742 689533
SGTC_164 4100-3994 89.624 µM 1.09194086950466 0.185514166402369 no 674 0.137429546159922 790 4615967
SGTC_1925 st057770 10.1 µM 1.09182921747857 0.185538620362352 no 675 0.137454087084567 639 5989122
SGTC_1036 k216-0215 33.5 µM 1.09144371431366 0.185623068411665 no 676 0.137538843020473 725 622330
SGTC_3184 9108758 49.47 µM 1.08960474038203 0.186026240892699 no 677 0.137943647019707 722 902885
SGTC_522 1273-0010 11.6 µM 1.08013015550222 0.188112019948768 no 678 0.140042112547604 699 5705015
SGTC_214 4373-3496 70 µM 1.07589906454997 0.189048115761396 no 679 0.140986200172788 906 3779166
SGTC_1502 4534-4282 27.7 µM 1.07129520710145 0.190069936465997 no 680 0.142018357107893 693 3278949
SGTC_1769 st044406 64.4 µM 1.06631928885937 0.191178144470391 no 681 0.143139666465572 750 670903
SGTC_3022 9087993 49.47 µM 1.06537762368004 0.191388311657966 no 682 0.143352539260713 720 17173644
SGTC_10 0279-0212 42.575 µM 1.06393149163778 0.191711344715616 no 683 0.143679867850775 827 39851 YBR002C RER2
SGTC_2843 9000894 45.46 µM 1.06387445836764 0.191724091492951 no 684 0.143692787527552 592 2242070
SGTC_2084 5306078 60.6385 µM 1.06363502582322 0.191777609663716 no 685 0.143747034442147 718 679340
SGTC_1107 amlodipine 47 µM 1.05981040656772 0.192633731467665 no 686 0.144615430745868 735 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_197 4544-0043 41.561 µM 1.05790931351828 0.193060149277701 no 687 0.145048394351305 759 896523
SGTC_2163 5671233 125 µM 1.05569575475444 0.193557379159574 no 688 0.145553618652938 800 701023
SGTC_3077 9117319 49.47 µM 1.05517100281519 0.19367536818501 no 689 0.14567356173497 700 17154678
SGTC_2726 cimetidine 79.27 µM 1.05507868610684 0.193696129877545 no 690 0.145694669529799 672 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1686 st019653 115.5 µM 1.0515937755575 0.194480865806951 no 691 0.146492982385328 755 97252
SGTC_3083 9117465 49.47 µM 1.04638268453409 0.195657909035166 no 692 0.147692191981963 737 16420915
SGTC_1765 st044815 90.4 µM 1.0462886196891 0.195679195376863 no 693 0.147713899023511 727 645695
SGTC_1217 1183-1422 255 µM 1.04612992280032 0.195715110770542 no 694 0.147750525836598 811 2849664
SGTC_2553 4-methylesculetin 85.09 µM 1.04459309737673 0.196063123483935 no 695 0.148105535598374 759 5319502
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.04453668316608 0.196075905568376 no 696 0.148118578246988 699 521171
SGTC_2777 climbazole 1.536 µM 1.04419779523976 0.196152699945497 no 697 0.148196943408017 783 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3351 9150312 21.596 µM 1.04384825621073 0.196231927042619 no 698 0.148277800609532 747 4904905
SGTC_1270 0831-1170 17.3 µM 1.04014030141025 0.197073572319699 no 699 0.149137361111388 820 6764716
SGTC_1478 0453-0656 35.7 µM 1.03897359101769 0.197338847736603 no 700 0.149408509325413 774 5258496
SGTC_2068 5226020 147 µM 1.03856840785362 0.197431024900644 no 701 0.149502752470692 785 1810509
SGTC_1491 4138-0063 26.5 µM 1.03440221204793 0.198380323237795 no 702 0.150474085362239 742 23883227
SGTC_610 4215-0184 155 µM 1.0333576271475 0.198618770756252 no 703 0.150718284122974 807 5605015
SGTC_2034 5197015 53.07 µM 1.0269301364878 0.20008977515781 no 704 0.152226681233014 775 780676
SGTC_1788 fluconazole 20 µM 1.02406580636194 0.200747413712146 no 705 0.152902096848881 725 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_47 0149-0135 24.25 µM 1.02247627998779 0.201112921590813 no 706 0.153277766823468 750 5239155
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.02203703808284 0.201213994581675 no 707 0.153381685374205 790 688798
SGTC_2755 lomerizine 42.69 µM 1.0213063261615 0.201382204561531 no 708 0.153554665074516 793 3949 A calcium channel blocker.
SGTC_2140 5586273 200 µM 1.02033715190757 0.201605438583313 no 709 0.153784294629816 733 854421
SGTC_1271 0832-2808 169 µM 1.01928088972738 0.201848900683039 no 710 0.154034816935031 825 3663794
SGTC_2071 5230951 39.92 µM 1.01919488277819 0.201868732516552 no 711 0.154055227785188 821 1799272
SGTC_1764 st044502 93.5 µM 1.01832045385808 0.202070428122689 no 712 0.154262845584305 781 8407
SGTC_314 1671-0008 2.74 µM 1.01632153209202 0.202531951744617 no 713 0.154738149141852 814 3913060
SGTC_2543 pimpinellin 60.67 µM 1.01513753891436 0.202805616449414 no 714 0.155020134818413 766 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1334 1486-0610 236 µM 1.01480113797699 0.202883411456775 no 715 0.155100315595786 799 3742339
SGTC_1630 st005209 31.3 µM 1.01280399439881 0.203345631433974 no 716 0.155576896204716 866 3367314
SGTC_2374 9071832 200 µM 1.01238125408594 0.203443551197084 no 717 0.155677898943039 765 17381698
SGTC_2309 7664088 163.95 µM 1.00949444054101 0.204112978309304 no 718 0.156368783264336 848 704922
SGTC_2270 7924575 90.91 µM 1.00862631379365 0.204314545725202 no 719 0.156576941340223 826 1262135
SGTC_926 2268-1401 59.4 µM 1.00749538868674 0.204577309085863 no 720 0.156848386297504 794 2931578
SGTC_3350 9150499 3.57 µM 1.00739598910114 0.204600413565941 no 721 0.156872259008409 846 4910996 YPR165W RHO1
SGTC_3167 9103034 49.47 µM 1.00644736342536 0.204820990604467 no 722 0.15710020987683 738 5127859
SGTC_131 0141-0277 33.849 µM 1.00345288537094 0.205518202013888 no 723 0.157821199191691 791 1547771
SGTC_2030 5175110 200 µM 1.00324767049713 0.205566034216462 no 724 0.157870688822637 791 2831986
SGTC_582 0987-0078 156 µM 1.00211615380656 0.205829890758027 no 725 0.158143748446676 911 1625765
SGTC_2399 5884133 200 µM 0.99906785948812 0.206541716680254 no 726 0.158880909768935 761 722445
SGTC_858 0438-0351 2.77 µM 0.998632997139656 0.206643382772857 no 727 0.158986254688886 843 2799119
SGTC_3053 9095903 49.47 µM 0.996853019222171 0.207059831079819 no 728 0.159417929325422 831 17174018
SGTC_2193 5925765 200 µM 0.995238123244023 0.207438085637602 no 729 0.159810232089775 775 877370
SGTC_268 camptothecin 39.6153 µM 0.994958266162065 0.207503677624879 no 730 0.159878281244626 894 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_971 1315-0384 26.7 µM 0.993207133745892 0.207914380550261 no 731 0.16030451128897 771 6769120
SGTC_330 1488-0319 80.1 µM 0.991769534170927 0.208251907346253 no 732 0.160654981235697 799 6846614
SGTC_72 0744-0168 198.391 µM 0.991249167317251 0.208374161314571 no 733 0.160781963842272 786 677577
SGTC_1234 0326-0494 15.5 µM 0.990882568607608 0.208460314707522 no 734 0.160871462489015 815 1547813
SGTC_1771 st048882 4.1505 µM 0.990177741124258 0.208626013354744 no 735 0.161043625116882 797 4580403
SGTC_117 lucigenin 22.078 µM 0.988655199803165 0.208984214118612 no 736 0.161415934479369 837 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_77 0828-0286 12.516 µM 0.987023326535497 0.209368538774973 no 737 0.161815601653899 798 745345
SGTC_562 3772-2733 112 µM 0.986782450338102 0.209425303056879 no 738 0.161874649963099 890 2876874 YIL048W NEO1
SGTC_3225 9130819 49.47 µM 0.985614635161607 0.209700635805474 no 739 0.162161126774094 823 4547121
SGTC_135 0933-0004 26.348 µM 0.98490928898711 0.209867036493302 no 740 0.162334315103068 767 21230617 YGL099W LSG1
SGTC_12 0849-0099 9.267 µM 0.983730837019471 0.210145222318404 no 741 0.162623936758896 805 6071388
SGTC_2555 cholic acid 100 µM 0.976792108866603 0.211787568059725 no 742 0.164336041754695 817 6708657 Influences liver metabolism.
SGTC_2485 5633444 17.78 µM 0.975054199075928 0.21220009157921 no 743 0.164766687949799 786 5724239
SGTC_980 1473-0395 201 µM 0.974885525023704 0.212240154329782 no 744 0.164808523502384 746 768876
SGTC_106 0092-0003 11.579 µM 0.973419037814422 0.212588654466588 no 745 0.165172540402326 769 1072148
SGTC_710 3448-4187 58 µM 0.96807685172236 0.213861009546432 no 746 0.166502994834022 902 3946412
SGTC_1311 1190-0148 100 µM 0.966088324028586 0.214335749764409 no 747 0.166999993271289 958 1961333
SGTC_1185 1319-0113 81.3 µM 0.964574888727383 0.214697477056075 no 748 0.167378890985346 798 4672763
SGTC_1781 st038725 66.3 µM 0.964100633429675 0.214810902126979 no 749 0.167497737585461 892 4270275 YIL048W NEO1
SGTC_3148 9097893 49.47 µM 0.963766664378743 0.214890796581222 no 750 0.167581461592057 780 17174100
SGTC_2354 9060492 162 µM 0.96332906327697 0.214995508753137 no 751 0.16769120631762 901 6471895
SGTC_2161 5662504 8.5105 µM 0.960819263076557 0.215596642871778 no 752 0.16832152562435 780 2859334
SGTC_648 0375-0473 33.3 µM 0.960469639771913 0.215680460077512 no 753 0.168409451917688 868 1713139
SGTC_2950 9072895 21.46 µM 0.960021309369921 0.215787968543671 no 754 0.168522245139334 838 17332245
SGTC_2686 alizarin 95.37 µM 0.959917438171021 0.215812881018486 no 755 0.168548384507244 788 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_405 ebelactone b 50 µM 0.95825112575588 0.216212757295888 no 756 0.168968071197286 846 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3072 9116419 49.47 µM 0.9576235269986 0.216363477570133 no 757 0.169126315577062 753 17170162
SGTC_3348 9149464 3.537 µM 0.957458410919158 0.216403140938735 no 758 0.169167964181094 856 1951442
SGTC_249 wiskostatin 11.211 µM 0.956409695209288 0.216655156467157 no 759 0.169432644203298 855 2775510 A n-wasp and actin depolymerizer.
SGTC_1958 st076513 41.9 µM 0.953774847142655 0.217289081939166 no 760 0.170098812021285 835 732122 YGL099W LSG1
SGTC_1940 st075990 51.1 µM 0.953564011152381 0.217339853806478 no 761 0.170152190055152 902 1084979
SGTC_837 0091-0265 12.5 µM 0.953348138323353 0.217391845703052 no 762 0.170206854402035 872 759367
SGTC_3285 9112818 20.8695 µM 0.95176858465528 0.217772491790983 no 763 0.170607178850182 890 17017947 YPR165W RHO1
SGTC_2908 7930301 100 µM 0.950930499968926 0.217974612237233 no 764 0.170819828854343 908 2223178
SGTC_2808 7946468 45.46 µM 0.94844035627779 0.218575796615497 no 765 0.171452661453165 865 2970879
SGTC_2520 obtusaquinone 4.71 µM 0.948335556092931 0.218601118976656 no 766 0.171479327661138 871 5967872
SGTC_3187 9109394 49.47 µM 0.947851312505387 0.218718146338499 no 767 0.171602576938028 844 17098090
SGTC_2659 sanguinarine 24.21 µM 0.946957964245664 0.218934136799384 no 768 0.171830099676409 811 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1611 st001856 99.4 µM 0.945853178256318 0.219201417513359 no 769 0.172111738822925 824 647478
SGTC_2331 7980721 200 µM 0.944961978162319 0.219417162044203 no 770 0.172339143851282 865 2981221
SGTC_2031 5180455 200 µM 0.944416298495504 0.219549322098737 no 771 0.172478477971896 822 29949
SGTC_3159 9100096 49.47 µM 0.940032825334831 0.220612628228765 no 772 0.173600361712394 846 25236875
SGTC_3043 9092303 49.47 µM 0.939000213544008 0.220863539201621 no 773 0.173865317350181 817 25236084
SGTC_1654 st012436 41.8 µM 0.938188087433859 0.221060989805875 no 774 0.174073879611067 828 4323132
SGTC_2969 9091408 28.7 µM 0.938096482230801 0.221083267934473 no 775 0.174097414737935 812 4286311
SGTC_1529 apigenin 74 µM 0.938095931492722 0.221083401876316 no 776 0.174097556239186 867 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_403 arphamenine a 50 µM 0.937566419311279 0.221212202972995 no 777 0.174233637740274 859 5487158 An arginine aminopeptidase inhibitor.
SGTC_2495 cafestol 54.53 µM 0.936696986345809 0.22142378111742 no 778 0.174457223439898 806 16667697 An anti-infammatory.
SGTC_1981 st071826 47 µM 0.935745636612484 0.221655426372849 no 779 0.17470208378751 817 11838600
SGTC_2437 5741531 144.16 µM 0.9348068748731 0.221884142245276 no 780 0.174943917979256 903 2262990
SGTC_2099 5377090 177.372 µM 0.93447867848552 0.221964134387447 no 781 0.175028514663969 846 2243829
SGTC_166 k072-0058 166.424 µM 0.934163382485795 0.222040997791188 no 782 0.175109810553137 905 5846229
SGTC_2779 methotrexate 400 µM 0.932685029921755 0.222401595723642 no 783 0.175491308204762 931 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.931821463168106 0.22261239031371 no 784 0.175714400285733 836 279621
SGTC_1475 4092-1048 11.7 µM 0.931568945605661 0.222674050765422 no 785 0.175779669096354 893 2881759
SGTC_2259 7964009 200 µM 0.924560817846728 0.22438919500192 no 786 0.177597201128443 822 313134
SGTC_2832 7992762 51.95 µM 0.924126023980958 0.224495851368311 no 787 0.177710352685472 751 2985177
SGTC_2181 6316240 54.2555 µM 0.923436637892892 0.224665018994928 no 788 0.177889853000742 827 12779990
SGTC_973 1325-0077 65.9 µM 0.922845010390336 0.224810255392612 no 789 0.178043990366802 958 2835149
SGTC_2311 7694451 200 µM 0.918754771777957 0.225815807645935 no 790 0.179111927046199 867 2163142
SGTC_1721 st082152 9.2685 µM 0.917920776675768 0.226021150404408 no 791 0.179330171734804 845 5296051
SGTC_337 1315-0038 354 µM 0.916982738259567 0.226252236344055 no 792 0.179575842798314 871 1626437
SGTC_1860 st056228 74.6 µM 0.915780963311556 0.226548488781328 no 793 0.17989089504111 860 688679
SGTC_1719 st032227 49.2 µM 0.915313211506667 0.226663854583625 no 794 0.180013612674708 890 3125804
SGTC_1027 k015-0025 8.67 µM 0.915115956521069 0.226712515278724 no 795 0.180065379516998 886 3598955
SGTC_446 go6976 132 µM 0.912815887761581 0.227280352584332 no 796 0.18066969046134 878 3501 A protein kinase C inhibitor.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.91274030455036 0.227299026037793 no 797 0.180689570451874 904 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1403 3909-7815 62.9 µM 0.911461879558281 0.227615002380355 no 798 0.181026031160902 863 6615483
SGTC_429 1112-0049 25.5 µM 0.907890349915177 0.228499053212825 no 799 0.181968078298014 830 2836170
SGTC_952 1185-0122 232 µM 0.90529607101685 0.229142415460478 no 800 0.182654278666913 891 678600
SGTC_246 cycloheximide 667 µM 0.902428144906603 0.22985482108575 no 801 0.183414737886301 813 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_653 0203-0016 55.2 µM 0.902261579227337 0.229896234808016 no 802 0.183458965000448 913 295302
SGTC_1875 nocodazole 6 µM 0.90206217508161 0.22994581874918 no 803 0.183511920243629 920 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1457 k015-0032 57.3 µM 0.901756889646419 0.230021742784131 no 804 0.183593012563394 897 4302660
SGTC_992 3909-8734 162 µM 0.900399695890396 0.230359444618882 no 805 0.183953791295436 891 4288319
SGTC_717 1532-0246 73.2 µM 0.899990074117229 0.230461422615557 no 806 0.184062766489554 882 9561992
SGTC_3044 9093193 49.47 µM 0.899636309622397 0.23054951488499 no 807 0.18415691382924 924 25236277
SGTC_1338 1486-1223 76 µM 0.897784105655098 0.231011046444372 no 808 0.184650329992906 936 3444526
SGTC_2301 7769476 200 µM 0.896508146422096 0.231329289319573 no 809 0.184990715691458 879 977820
SGTC_3112 9123419 49.47 µM 0.896028331713314 0.231449025353294 no 810 0.185118815932777 975 17015854
SGTC_3317 9138495 8.753 µM 0.895294574897028 0.231632198536949 no 811 0.185314819802721 906 17020139
SGTC_3297 9117502 71.43 µM 0.894727369129084 0.231773849688993 no 812 0.185466422200328 930 7453720
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.894457138299216 0.231841352764029 no 813 0.185538676391541 907 756377
SGTC_1724 st037281 8.293 µM 0.894242226468056 0.231895045090035 no 814 0.185596151884389 893 574124 YDL195W SEC31
SGTC_158 k038-0087 26.446 µM 0.893310897049906 0.232127803048259 no 815 0.185845351996213 956 X158
SGTC_2324 6149169 200 µM 0.891277801634502 0.232636365990654 no 816 0.18639007726554 888 2888231
SGTC_1988 st071872 53.4 µM 0.889892638114838 0.232983208260917 no 817 0.186761768654249 947 16414116
SGTC_566 0958-0068 16.5 µM 0.88913679523539 0.233172590906801 no 818 0.1869647830252 856 6815365
SGTC_630 4356-0227 183 µM 0.888772957954585 0.233263783787301 no 819 0.187062555961741 891 779312
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.888486099147363 0.233335696586836 no 820 0.187139664990665 984 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3341 9147222 25.867 µM 0.88776196136771 0.233517285815067 no 821 0.187334404145054 871 1939759
SGTC_1420 4'-methoxyflavone 42 µM 0.887710963448035 0.233530077319621 no 822 0.187348123509454 943 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_387 norethindrone acetate 66.7 µM 0.887314935191839 0.233629423954154 no 823 0.187454683424605 874 541197
SGTC_336 4111-0029 111 µM 0.887255259126638 0.233644396170427 no 824 0.187470743799748 864 3131175
SGTC_1003 4049-0218 100 µM 0.883668747374436 0.234545197512329 no 825 0.18843752792016 943 295161
SGTC_3318 9139014 38.6185 µM 0.88282300830132 0.234757895989488 no 826 0.188665953554912 902 16643984
SGTC_2892 9047358 58.44 µM 0.881244899161758 0.235155066272816 no 827 0.189092641167151 861 6466771
SGTC_2054 5233173 129 µM 0.881179114881377 0.235171630570846 no 828 0.189110440750967 932 6889
SGTC_2883 9059145 45.46 µM 0.880798678241606 0.235267436091044 no 829 0.18921339764464 903 16476510
SGTC_1683 st010134 710 nM 0.879254485243617 0.235656532027643 no 830 0.189631654099836 917 3818134
SGTC_2053 5265679 138 µM 0.87519246339641 0.236681747231609 no 831 0.190734596632496 948 764595
SGTC_1615 st002656 86.5 µM 0.873762735858442 0.23704317958495 no 832 0.191123738931074 918 1584458
SGTC_2286 7945697 125 µM 0.873235801622991 0.237176463995196 no 833 0.191267282230544 931 1245733
SGTC_779 1360-0071 233 µM 0.873221602057147 0.237180056247826 no 834 0.191271151279285 999 7566
SGTC_3301 9125354 19.7965 µM 0.872373219804144 0.237394736998572 no 835 0.191502402603721 868 41905162
SGTC_2171 5739187 198.077 µM 0.86948404373254 0.238126634597817 no 836 0.192291215921008 916 2262761
SGTC_1037 k284-1091 78.7 µM 0.868099300759413 0.238477861071602 no 837 0.192669986914918 899 3334711
SGTC_609 0986-0026 86.3 µM 0.867953654694344 0.238514819244677 no 838 0.192709852202119 942 2848610
SGTC_1075 aripiprazole 15.2 µM 0.864754606206019 0.239327378687722 no 839 0.193586745500128 1001 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3030 9087619 49.47 µM 0.864240225612206 0.23945817251107 no 840 0.193727969462987 979 25236973
SGTC_1736 st036774 51 µM 0.864162152502149 0.239478027916503 no 841 0.193749410041426 1001 1272247
SGTC_15 0266-0086 27.098 µM 0.862731011042069 0.239842152329369 no 842 0.19414268895896 1037 1712902 YIL048W NEO1
SGTC_1397 3532-0190 20.1 µM 0.859949180537819 0.240550794965619 no 843 0.194908528328976 909 5322280
SGTC_2630 antimycin a 100 µM 0.856010842424862 0.241555992382174 no 844 0.195995891092762 1026 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1407 3909-7909 12.3 µM 0.855224991592449 0.241756840783643 no 845 0.196213301630186 992 4411780
SGTC_384 k007-0144 5.16 µM 0.855086470904972 0.24179225340858 no 846 0.196251639396914 979 6824886
SGTC_82 0054-0107 293.755 µM 0.854291927739599 0.241995431656019 no 847 0.196471629368304 984 3104697
SGTC_1984 st072354 53.1 µM 0.854282432020156 0.241997860433369 no 848 0.196474259408911 960 5762938
SGTC_1473 k844-0725 134 µM 0.850466074653245 0.242975062757823 no 849 0.197533007078389 1087 54682906
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.849257639409805 0.243284934587448 no 850 0.197868973250395 972 279621
SGTC_3334 9142812 21.919 µM 0.848745964954879 0.243416204550432 no 851 0.198011331679553 937 45283678
SGTC_2139 5578692 56.4705 µM 0.846730524339367 0.243933637417698 no 852 0.198572670382374 947 650991 YMR113W FOL3
SGTC_3338 9144300 39.5675 µM 0.846621074687812 0.243961753883719 no 853 0.19860318165325 965 4901274
SGTC_1470 k295-0292 231 µM 0.845395052746813 0.244276825498781 no 854 0.198945152893196 1003 5045612
SGTC_3089 9117425 49.47 µM 0.843909657093287 0.244658846436074 no 855 0.199359945681073 915 9401657
SGTC_820 1582-0060 59.9 µM 0.843791827270223 0.244689164222224 no 856 0.199392871622332 955 3848840
SGTC_2145 5634607 200 µM 0.842983243267664 0.244897268631754 no 857 0.199618907732157 929 308662
SGTC_1006 4099-6547 255 µM 0.84239168524879 0.245049577602547 no 858 0.199784372807539 970 3146833
SGTC_2735 sertaconazole 140 nM 0.840886297851165 0.245437400752824 no 859 0.200205817643916 966 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3046 9092212 49.47 µM 0.840169131148489 0.245622275662723 no 860 0.200406781757936 954 25236637
SGTC_1156 4092-0367 4.88 µM 0.839583831073844 0.245773212727308 no 861 0.200570884035096 973 1357585
SGTC_192 3455-0609 60.9 µM 0.838545031271589 0.24604122077758 no 862 0.200862333953081 980 3769639
SGTC_3335 9143315 29.6265 µM 0.838355388437906 0.246090165127385 no 863 0.200915568340602 961 4899691
SGTC_1780 st038448 24.544 µM 0.837999847160065 0.246181939780767 no 864 0.201015394669018 987 728868 YDL195W SEC31
SGTC_1929 genistein trimethyl ether 50.5 µM 0.836442185559318 0.246584229893774 no 865 0.201453094309678 1028 136420
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.836143967021868 0.246661289570098 no 866 0.201536958186959 967 5377381
SGTC_2666 tannic acid 100 µM 0.835929992976581 0.246716588413594 no 867 0.201597144036921 1018 16134267 A thiamine antagonist.
SGTC_3000 9075062 71.4286 µM 0.835262859491929 0.246889043099425 no 868 0.201784862052601 931 17057871
SGTC_2017 5132927 60.65 µM 0.832977706610571 0.247480246114402 no 869 0.202428651214981 1022 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1087 pterostilbene 9.05 µM 0.832750794728918 0.247538992851105 no 870 0.20249264537258 1009 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3224 9130643 49.47 µM 0.832706195517156 0.247550540315762 no 871 0.202505224756523 977 17644395
SGTC_3070 9117005 49.47 µM 0.832678176458427 0.247557795055076 no 872 0.202513127881721 976 8779016
SGTC_1092 toremifene 6.32 µM 0.832614542595454 0.247574271658123 no 873 0.202531077291842 1066 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2995 9067767 71.4286 µM 0.832613680262385 0.247574494944516 no 874 0.202531320539459 930 11673567
SGTC_1399 3562-5772 25 µM 0.832101237655597 0.247707202213753 no 875 0.202675901656215 912 23847490
SGTC_931 2812-0076 566 µM 0.831873537350524 0.247766181952531 no 876 0.202740165056869 1025 3450959
SGTC_126 0417-1624 672.48 µM 0.831862367790594 0.247769075324384 no 877 0.202743317732618 1139 41912 YDL195W SEC31
SGTC_2838 9002687 71.43 µM 0.831078383808721 0.24797220423399 no 878 0.202964675124869 928 6457060
SGTC_556 4058-0063 51.5 µM 0.830820223624128 0.248039112540689 no 879 0.203037598071351 1038 6615692
SGTC_2803 7707263 71.43 µM 0.829763158356864 0.2483131763941 no 880 0.203336352234352 948 2199229
SGTC_3292 9120825 59.784 µM 0.829648156654331 0.24834300246101 no 881 0.203368870523058 1026 24824900
SGTC_2289 7946404 165.07 µM 0.829040173380841 0.248500716639289 no 882 0.203540837585465 1046 1246120 YPR165W RHO1
SGTC_692 k241-0027 77.8 µM 0.827883903701855 0.24880080650611 no 883 0.203868125770642 997 3600480
SGTC_2751 anetholtrithion 17.25 µM 0.827302585662271 0.248951750435621 no 884 0.204032789300754 958 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2268 7933382 153.85 µM 0.827272953698687 0.248959445919768 no 885 0.20404118494114 1107 935025 YOR257W CDC31
SGTC_2791 5663188 71.43 µM 0.825870462994475 0.249323820490956 no 886 0.204438788750521 974 54690634
SGTC_1697 st025554 27.742 µM 0.825006497648303 0.249548424340682 no 887 0.204683950887167 995 1269519
SGTC_3246 9135460 32.98 µM 0.823040589163091 0.250059899131074 no 888 0.205242455996044 950 41446951
SGTC_2738 aclarubicin 5.55 µM 0.821543156258849 0.250449862430623 no 889 0.205668476296327 918 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1466 k213-0079 57.5 µM 0.820547286745851 0.250709386315458 no 890 0.205952091970978 1009 3657981
SGTC_1315 1237-0019 3.69 µM 0.820401397899843 0.250747416947532 no 891 0.205993659420448 1029 825140
SGTC_1199 1638-0010 4.46 µM 0.819118821822257 0.251081893198334 no 892 0.206359312136791 990 3111136
SGTC_2757 clomiphene 4.22 µM 0.81678644377618 0.251690746140346 no 893 0.20702524028806 1097 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1975 st070967 30.8 µM 0.815422502117414 0.252047155700389 no 894 0.207415254137878 1082 261391
SGTC_2795 7780010 54.55 µM 0.814051052729163 0.252405795393801 no 895 0.207807852393788 964 953673
SGTC_2345 9052315 157.45 µM 0.813105336806172 0.252653260617788 no 896 0.208078833458311 996 6469265
SGTC_704 1310-0270 142 µM 0.813092853885996 0.252656527874338 no 897 0.208082411650585 1061 5718033
SGTC_1090 efavirenz 20.7 µM 0.811707921381909 0.253019155708711 no 898 0.20847962396257 1017 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1474 0330-0125 5.35 µM 0.810795103182732 0.253258315761812 no 899 0.208741673532202 1061 X1474
SGTC_265 mycophenolic acid 32.932 µM 0.809645191889858 0.253559763737985 no 900 0.209072063337614 1071 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3191 9110352 49.47 µM 0.807281418963987 0.254180015694368 no 901 0.209752183333342 1017 17122424
SGTC_2902 5787006 60.46 µM 0.805279357517896 0.254705976559757 no 902 0.210329245515006 997 591003
SGTC_635 k038-0028 24.7 µM 0.803068792533784 0.255287374645916 no 903 0.210967487076136 1031 4035102
SGTC_2122 5258151 111.688 µM 0.799139390560415 0.256322552126191 no 904 0.212104795681038 1007 2173356
SGTC_3058 9093861 49.47 µM 0.798996328862572 0.256360282111035 no 905 0.212146270345044 1012 17217477
SGTC_2922 7999257 32.47 µM 0.798632462705805 0.256456258395913 no 906 0.212251779248697 986 2988377
SGTC_2377 9073351 62.6 µM 0.797149183138182 0.256847693847391 no 907 0.212682197489984 1008 7337946 YHR072W ERG7
SGTC_1845 st056753 3.01 µM 0.797142494980689 0.256849459546918 no 908 0.212684139413814 1055 5375839
SGTC_2466 5983409 37.09 µM 0.796878101371661 0.256919265546062 no 909 0.212760915076215 992 2879657
SGTC_3130 9127414 49.47 µM 0.796016861581189 0.257146721107009 no 910 0.21301111746064 1069 1494646
SGTC_1129 3453-1384 223 µM 0.795391331923449 0.257311990658461 no 911 0.213192950281686 1050 1084452
SGTC_819 1013-0258 27.7 µM 0.795075083271486 0.257395566891527 no 912 0.213284913832845 1048 5753198
SGTC_2706 st078239 82.5 µM 0.790852201236452 0.25851291416952 no 913 0.214515121959391 1081 15434492
SGTC_1024 4507-0395 26 µM 0.788835174516563 0.259047491536564 no 914 0.215104174075798 1015 4201836
SGTC_674 0498-0004 451 µM 0.786053710491418 0.259785606103412 no 915 0.215918010721675 1020 4231473
SGTC_2455 5377712 9.75 µM 0.785014725874692 0.260061598639686 no 916 0.21622246734679 986 2243908
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.783237837427326 0.260533955690694 no 917 0.216743729690443 1093 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1263 0774-1208 64.8 µM 0.782587013484514 0.26070707717156 no 918 0.216934835010786 1099 906585
SGTC_2853 9015042 58.44 µM 0.780129252408953 0.261361383840985 no 919 0.217657399869226 1048 6457456
SGTC_2198 6589944 200 µM 0.778320681524658 0.26184340081556 no 920 0.218189993057852 997 5290268
SGTC_459 nigericin 15.3 µM 0.778035740739277 0.261919384262304 no 921 0.218273971673382 1141 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2204 7233102 200 µM 0.776645708789887 0.262290217773168 no 922 0.218683913041458 1020 2172480
SGTC_2433 5607874 27.82 µM 0.776245524983579 0.262397028871151 no 923 0.218802015379895 1087 2252428
SGTC_2987 9018338 71.43 µM 0.776175423852699 0.262415741512553 no 924 0.218822707419015 1079 5055682
SGTC_2386 9075165 157.42 µM 0.772335978395761 0.263441677137381 no 925 0.219957730764391 1066 16452277
SGTC_1506 4226-2149 212 µM 0.771385055130668 0.263696088679464 no 926 0.220239365366498 1119 991114
SGTC_1669 st015249 58.4 µM 0.769547712378599 0.264188009070152 no 927 0.220784115836008 1179 722793
SGTC_3237 9133362 49.47 µM 0.768412149293647 0.264492272232911 no 928 0.221121182354393 1057 43845137
SGTC_3218 9131285 49.47 µM 0.767670626097825 0.264691052405597 no 929 0.221341445756872 1099 17156417
SGTC_1520 flindersine 88 µM 0.767134839156333 0.26483472811282 no 930 0.221500674940315 1130 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3033 9090887 49.47 µM 0.766634107104062 0.264969039390535 no 931 0.221649545424924 1121 19325384
SGTC_2688 kanamycin b 96.69 µM 0.766197219058142 0.265086254068143 no 932 0.221779481416103 1278 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_409 arachidonic acid 100 µM 0.765573728868745 0.265253578685936 no 933 0.221964990566804 1119 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2823 7987624 58.44 µM 0.763661824976978 0.265767006008164 no 934 0.222534397902335 1070 2239440
SGTC_1009 4106-0057 9.87 µM 0.761661177194384 0.266304803693846 no 935 0.223131125911062 1134 2928005
SGTC_3036 9090181 49.47 µM 0.761356206903236 0.26638683165074 no 936 0.223222168561871 1091 25236586
SGTC_1986 st071812 45 µM 0.761206465595835 0.266427112297159 no 937 0.223266878509453 1048 11838594
SGTC_2440 5628896 157.78 µM 0.760411414994978 0.26664103375648 no 938 0.223504351073118 1083 5522048
SGTC_3322 9139058 2.11 µM 0.759877542501729 0.26678472966285 no 939 0.223663893307774 1075 4908926 YPR165W RHO1
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.757769213629258 0.267352584842902 no 940 0.224294577871022 1041 15053
SGTC_1816 st051957 91.6 µM 0.75660874927269 0.267665403121739 no 941 0.22464214901587 1090 674121
SGTC_363 0455-0021 3.06 µM 0.756234764897889 0.267766254770745 no 942 0.22475422628596 1106 4597466
SGTC_906 1165-0455 526 µM 0.754325351672805 0.268281460808685 no 943 0.225326941554783 1110 3252859
SGTC_469 w7 172 µM 0.752880452752335 0.26867166080235 no 944 0.225760877707172 1162 45115570 A P450 inhibitor.
SGTC_850 0388-0143 75.9 µM 0.751377129060032 0.269077941073069 no 945 0.226212861488671 1062 67273
SGTC_1752 st044819 83.042 µM 0.751214372531244 0.269121945276905 no 946 0.22626182592324 1085 441209 YML126C ERG13
SGTC_940 3232-1287 54.8 µM 0.749877032854036 0.269483656189733 no 947 0.226664384094955 1099 1585493 YIL048W NEO1
SGTC_2705 st078069 42.8 µM 0.749778939017467 0.26951019726619 no 948 0.22669392763175 1072 1530061
SGTC_3048 9093155 49.47 µM 0.749661994173025 0.269541840538406 no 949 0.226729151484433 1093 25236002
SGTC_871 0574-0004 149 µM 0.745839991840579 0.270577032532561 no 950 0.227882039233226 1074 9551173
SGTC_1749 st037932 54.2 µM 0.744460165018812 0.270951246895419 no 951 0.228299065992485 1061 594497
SGTC_3142 9086498 49.47 µM 0.743610798963346 0.271181726580018 no 952 0.228555984079949 1065 25236367
SGTC_2408 sulbentine 18.36 µM 0.741911993981163 0.271642998797725 no 953 0.229070329209318 1073 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_563 tetrahydrosecaminediol 614 µM 0.739423504714395 0.272319396451262 no 954 0.229824936959465 1163 334274 A psychoactive constituent of the cannabis plant.
SGTC_2567 aureobasidin a 60 nM 0.738123793333822 0.272673004071218 no 955 0.230219613161259 1134 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1347 1493-0251 600 nM 0.73622316524678 0.273190510773177 no 956 0.230797448363879 1135 3986378
SGTC_552 k242-0005 476 µM 0.733279406502398 0.273993002466553 no 957 0.23169401632995 1144 4088318
SGTC_2917 7979103 53.79 µM 0.733253122099588 0.274000173044952 no 958 0.231702030389747 1140 2980565
SGTC_1718 roemerine 11.9335 µM 0.732702506695203 0.274150406294124 no 959 0.231869947386862 1099 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1614 st002383 48.6 µM 0.732609961531887 0.274175660871898 no 960 0.231898176834212 1181 1947235
SGTC_235 0330-0087 5 mM 0.729952700606367 0.274901288541167 no 961 0.232709548541639 1180 46494818 YHR062C RPP1
SGTC_2909 7941780 10.49 µM 0.725276051935738 0.276180651654756 no 962 0.234141347197314 1163 1243215
SGTC_1318 1280-3875 124 µM 0.72507085882353 0.276236851973158 no 963 0.234204280453694 1132 373245
SGTC_1936 st074407 74.3 µM 0.724560158455862 0.276376752000133 no 964 0.234360954225105 1189 809813
SGTC_1203 3992-3522 103 µM 0.724409534479353 0.276418020204462 no 965 0.234407174050596 1224 5322312
SGTC_3248 9135562 49.47 µM 0.723634780241896 0.276630336379922 no 966 0.234644991480683 1191 17650701
SGTC_2396 5342950 42.78 µM 0.720611983201678 0.277459476976256 no 967 0.235574139491993 1152 1886677
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.720579542173598 0.277468381998956 no 968 0.235584122218606 1127 442882
SGTC_2160 5660466 132.927 µM 0.719853255400988 0.277667783398702 no 969 0.23580767567548 1114 2859134
SGTC_2596 sinensetin 100 µM 0.718608931137542 0.278009574148899 no 970 0.23619095447259 1139 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2471 5466956 24.79 µM 0.718376285188093 0.27807350006506 no 971 0.236262652513181 1115 724419
SGTC_391 gliotoxin 8.33 µM 0.718226711248695 0.278114603433185 no 972 0.236308755318159 1178 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_458 nppb 133 µM 0.715747183738003 0.278796416472146 no 973 0.237073735174579 1160 4549 A chloride channel blocker.
SGTC_1760 st045453 10.4495 µM 0.714173044035078 0.279229690447038 no 974 0.237560091539214 1184 3323419 YIL048W NEO1
SGTC_169 k015-0017 16.025 µM 0.713690181748112 0.279362661402804 no 975 0.237709389460434 1185 1840002
SGTC_264 promethazine 12.5 mM 0.712929758656087 0.279572129596007 no 976 0.23794461172565 1229 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1692 fluoroquinolonic acid 71 µM 0.712598947230067 0.279663279597427 no 977 0.238046981700603 1175 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_750 4073-0104 132 µM 0.710746429427714 0.280173978753663 no 978 0.238620691306712 1033 22330957
SGTC_2696 st077691 74.316 µM 0.708727718153136 0.280731007846348 no 979 0.239246730281675 1148 757133
SGTC_1228 0124-0032 52.5 µM 0.707927317082502 0.280952013118092 no 980 0.23949519738548 1212 X1228
SGTC_1463 k081-0032 34.1 µM 0.707896577999133 0.280960502413661 no 981 0.239504742473922 1025 977755
SGTC_2490 carminic acid 95.39 µM 0.707107967009906 0.281178337614141 no 982 0.239749692662392 1136 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1903 st060211 78.3 µM 0.705764400400283 0.281549653976204 no 983 0.240167332068038 1201 688960
SGTC_2180 6301957 200 µM 0.704231790999871 0.281973503936903 no 984 0.240644217993472 1164 845462
SGTC_2570 licareol 100 µM 0.704171891520959 0.281990075643587 no 985 0.240662866744146 1140 443158
SGTC_1907 st060210 83.7 µM 0.703507683933134 0.282173865826395 no 986 0.240869709933536 1208 688793
SGTC_2094 5332512 191.667 µM 0.701209691427556 0.282810178458133 no 987 0.241586081291838 1206 755774
SGTC_592 k241-0073 46.5 µM 0.700541274353052 0.282995392027303 no 988 0.241794669200737 1203 4230158
SGTC_912 3474-0017 2.18 µM 0.700426746668786 0.283027132668154 no 989 0.24183041880215 1209 3360550
SGTC_1948 st076329 66.6 µM 0.700272927184067 0.28306976547759 no 990 0.241878437777711 1103 24208413
SGTC_3296 9122258 64.045 µM 0.697725415909232 0.283776284868749 no 991 0.242674465170677 1179 4730474
SGTC_1412 3909-8563 178 µM 0.697494915077108 0.28384025293297 no 992 0.242746560262448 1249 23767530
SGTC_1165 k072-0275 30.3 µM 0.697369230713303 0.283875135478251 no 993 0.242785876178804 1212 6153523 YGL055W OLE1
SGTC_549 1661-1316 519 µM 0.696769792013525 0.284041532430183 no 994 0.242973436822142 1223 2857282
SGTC_2086 5274770 176.623 µM 0.696009203537544 0.284252729754029 no 995 0.24321153300751 1195 689278
SGTC_1389 3405-0187 19 µM 0.693050806826577 0.285074919226923 no 996 0.244138833865307 1150 799890
SGTC_656 4090-1979 187 µM 0.691474428594792 0.285513484451597 no 997 0.244633722562607 1217 22330961
SGTC_1734 st037168 69.4 µM 0.688603025315235 0.286313163785851 no 998 0.245536558365096 1185 708907
SGTC_2277 7947813 106.88 µM 0.686862831764083 0.286798320696147 no 999 0.246084585461718 1260 1246798
SGTC_347 4534-1311 26.2 µM 0.68655994581144 0.286882803520769 no 1000 0.246180038228814 1221 2862016
SGTC_1007 4101-0031 70 µM 0.686537110449227 0.286889173379347 no 1001 0.246187235466767 1186 1146276
SGTC_1834 st055981 52.8 µM 0.683721116997906 0.287675199866028 no 1002 0.247075643142554 1240 471719 YDL150W RPC53
SGTC_1341 1486-1360 280 µM 0.682853631557987 0.287917545419783 no 1003 0.247349668147152 1213 3976547
SGTC_2939 9044578 71.43 µM 0.682551407463708 0.288001999059602 no 1004 0.247445174128355 1205 2653634
SGTC_37 0566-0070 1.56 µM 0.682239655658264 0.288089127378065 no 1005 0.24754371161095 1228 1626686
SGTC_2496 diffractaic acid 79.83 µM 0.680861530247725 0.288474434485369 no 1006 0.247979556000776 1277 94870 An apoptosis inducer which activates caspases.
SGTC_553 k007-0256 45.7 µM 0.680713060083845 0.288515959425669 no 1007 0.248026535429402 1252 6287000
SGTC_2587 piperic acid 92.2 µM 0.678732795937857 0.289070079572503 no 1008 0.248653591066009 1187 5370536
SGTC_2863 9028737 58.44 µM 0.678353447135366 0.289176286559048 no 1009 0.24877380911691 1210 6460917
SGTC_1959 st077091 55.8 µM 0.677697815259649 0.289359888271131 no 1010 0.248981655974139 1238 821356 YKL052C ASK1
SGTC_2081 5214970 32.255 µM 0.677062092129494 0.289537967067232 no 1011 0.249183279614992 1189 2063512
SGTC_2979 9012552 45.46 µM 0.675763596669186 0.289901861502371 no 1012 0.249595375393996 1281 17100905
SGTC_2732 terfenadine 20 µM 0.675468325191608 0.289984639228789 no 1013 0.249689134444381 1217 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1594 piperine 70.1 µM 0.674514770207006 0.290252038749756 no 1014 0.249992049293768 1227 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2781 5567276 71.43 µM 0.674204298690857 0.290339127273393 no 1015 0.250090718532692 1232 2853274
SGTC_358 0075-0058 9.45 µM 0.673512592107598 0.290533197771073 no 1016 0.250310620249942 1242 1069125
SGTC_2199 6590217 200 µM 0.672746432323603 0.290748228260307 no 1017 0.250554311127437 1184 703109
SGTC_1579 chlormadinone acetate 49.4 µM 0.672112020343126 0.290926338702095 no 1018 0.250756192342517 1238 45114258 A steroidal progestin.
SGTC_1170 0310-0127 64.8 µM 0.671636249729141 0.291059944209899 no 1019 0.250907647542213 1219 774975
SGTC_1571 st070080 73.4 µM 0.67084331303824 0.291282679697444 no 1020 0.251160175865501 1275 4315245
SGTC_1416 3966-0321 25.3 µM 0.670666214865493 0.291332437344922 no 1021 0.251216595076243 1241 582530 YLR208W SEC13
SGTC_2010 4012422 159 µM 0.670351148478632 0.291420968458827 no 1022 0.251316984201476 1214 952393
SGTC_3009 9080819 71.4286 µM 0.66735186220943 0.292264371462855 no 1023 0.252273703199765 1242 17027216
SGTC_3183 9108214 49.47 µM 0.667007542463157 0.292361267210278 no 1024 0.252383657827667 1157 4974831
SGTC_2393 9031399 185.94 µM 0.66658778148883 0.29247941323471 no 1025 0.252517737922262 1275 1526623 YDL150W RPC53
SGTC_965 1291-5240 308 µM 0.66496781106608 0.292935578449248 no 1026 0.253035540755718 1243 2834598
SGTC_1806 st050005 60.3 µM 0.664102205107964 0.29317945848991 no 1027 0.253312449456603 1221 5194765
SGTC_2695 st077686 51.995 µM 0.662723751785364 0.293568024856244 no 1028 0.253753747464177 1223 2876092
SGTC_1266 0828-0227 32.9 µM 0.661690296496377 0.293859497501413 no 1029 0.254084862378014 1217 3913820
SGTC_1135 dihydrocapsaicin 536.708 nM 0.660675432612073 0.294145856884655 no 1030 0.254410241109269 1213 107982 A Capsaicinoid.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.660002234567709 0.294335881128898 no 1031 0.25462619767997 1251 688664
SGTC_707 0865-0008 204 µM 0.6598848850741 0.29436901128193 no 1032 0.254663852287415 1263 723043
SGTC_2438 5259590 200 µM 0.659659650512387 0.294432604411285 no 1033 0.254736132766842 1256 1201127
SGTC_159 3970-0959 50 µM 0.658583354736015 0.294736575210244 no 1034 0.255081677272434 1328 6615653
SGTC_1941 st076221 61.8 µM 0.657236695106539 0.295117106678599 no 1035 0.25551436707507 1250 2828568
SGTC_2136 5328288 199.296 µM 0.656532103988109 0.295316296169017 no 1036 0.25574090912046 1232 262395
SGTC_3138 9097216 49.47 µM 0.647867442413527 0.297770857490661 no 1037 0.258535345024389 1270 25237486
SGTC_1459 k035-0031 35.7 µM 0.647681836723746 0.297823538309342 no 1038 0.258595377156266 1166 3877128 YMR208W ERG12
SGTC_1479 0549-0158 134 µM 0.647189169115379 0.297963393712106 no 1039 0.258754760109925 1304 5440202
SGTC_144 4161-2749 112.381 µM 0.645726632299632 0.298378745764103 no 1040 0.259228204877262 1201 797501 YMR168C CEP3
SGTC_1836 st055642 81 µM 0.645504693742344 0.298441798061331 no 1041 0.259300088772265 1247 8571
SGTC_1935 st074532 41.6 µM 0.643611409605486 0.298979922560541 no 1042 0.259913724869638 1329 2829742
SGTC_321 4534-3890 65.3 µM 0.642479694352716 0.299301798089448 no 1043 0.260280884725644 1298 699746
SGTC_897 1000-0139 31.4 µM 0.639614701212674 0.300117343712373 no 1044 0.261211561229483 1272 6151020
SGTC_3245 9134821 49.47 µM 0.638680656559249 0.300383444861236 no 1045 0.261515349449353 1240 17014901
SGTC_2869 9037858 32.47 µM 0.638381285972803 0.300468755476037 no 1046 0.261612754960284 1243 27187042
SGTC_895 0964-0006 13.7 µM 0.637145314875786 0.300821081745408 no 1047 0.26201509703898 1263 6738897
SGTC_628 1636-0253 16 µM 0.636451109037316 0.301019053957111 no 1048 0.262241218883092 1268 4456143
SGTC_2128 5255449 168.493 µM 0.635115861422265 0.301400002180952 no 1049 0.262676426473057 1275 736008
SGTC_1152 3909-8331 15.9 µM 0.631178322214209 0.302524649693836 no 1050 0.263961967190367 1275 16001939
SGTC_510 ag-490 170 µM 0.629578553045301 0.302982115635329 no 1051 0.264485179613095 1409 5328779
SGTC_2870 9038528 12.99 µM 0.626228482249978 0.303941094792082 no 1052 0.265582543951142 1287 6463316
SGTC_2903 5923464 63.88 µM 0.625494389398692 0.304151414213628 no 1053 0.265823314814246 1333 2876576
SGTC_743 1275-0778 158 µM 0.624999731463774 0.304293171496474 no 1054 0.265985617171816 1314 2849257 YMR203W TOM40
SGTC_1371 2421-0008 32.7 µM 0.624485267756138 0.304440635850657 no 1055 0.266154471246473 1305 2827552
SGTC_3327 9140648 26.9345 µM 0.623948544987992 0.304594514367156 no 1056 0.266330688880329 1296 8029710
SGTC_209 4077-0173 175.592 µM 0.623685150969971 0.304670042133546 no 1057 0.266417188395896 1257 15993494
SGTC_849 0386-0493 241 µM 0.622994126699083 0.30486823168845 no 1058 0.266644190718555 1285 726119
SGTC_2552 juarezic acid 87.02 µM 0.622055578903624 0.305137504051533 no 1059 0.266952661346749 1346 1549512
SGTC_2529 gangaleoidin 93.61 µM 0.621123633486186 0.305404986584691 no 1060 0.267259140235124 1362 4565183
SGTC_1756 st041558 35.5 µM 0.620736275112017 0.305516194922429 no 1061 0.267386578844666 1378 3955792
SGTC_1161 k007-0610 110 µM 0.620412867707102 0.305609057055777 no 1062 0.267493001439171 1368 5843850
SGTC_789 1309-1135 70.6 µM 0.619230373773321 0.305948700871135 no 1063 0.267882302508147 1309 3092424
SGTC_2681 menadione 3.18 µM 0.619107859726792 0.305983899723175 no 1064 0.26792265293437 1322 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1016 4226-1401 38 µM 0.619013233949128 0.306011087373026 no 1065 0.267953820357421 1312 2901613
SGTC_760 0568-0725 82.9 µM 0.618053199290865 0.306286982617818 no 1066 0.26827013554933 1318 3916171
SGTC_2802 7925815 54.55 µM 0.616600666407161 0.306704621108384 no 1067 0.268749077436656 1306 1262923
SGTC_3277 9138724 49.47 µM 0.614948313443582 0.307180017995257 no 1068 0.26929442748256 1283 15943418
SGTC_195 4234-0266 16.654 µM 0.614824087060785 0.307215772163721 no 1069 0.269335450139222 1302 2303354
SGTC_3037 9091026 49.47 µM 0.60954329616673 0.308737352268521 no 1070 0.27108219186447 1340 25236398 YIL048W NEO1
SGTC_1026 k007-1105 30.6 µM 0.608976259900952 0.308900931209584 no 1071 0.271270087369181 1330 7066794
SGTC_2113 5491891 107.031 µM 0.608709441473749 0.308977916258273 no 1072 0.271358523891758 1304 789979
SGTC_43 0570-0105 72.5 µM 0.605493776677502 0.309906390355187 no 1073 0.272425479245585 1369 1114046 YDL195W SEC31
SGTC_1818 st052136 56.3 µM 0.605092121567371 0.310022447522818 no 1074 0.272558894365639 1247 674169
SGTC_1168 k815-0004 80.5 µM 0.603398733007035 0.31051195565306 no 1075 0.273121732447801 1312 642433
SGTC_3092 9117248 49.47 µM 0.601301727857417 0.311118602599603 no 1076 0.27381951947432 1386 17141857
SGTC_994 3910-0338 138 µM 0.600466096503916 0.311360487297146 no 1077 0.274097824648754 1424 3479481
SGTC_943 3253-1379 105 µM 0.599533972100492 0.311630399318094 no 1078 0.274408431419341 1377 668464
SGTC_2978 9011784 42.97 µM 0.598484472754148 0.311934420361544 no 1079 0.274758358198266 1418 2994934
SGTC_222 nsc-310342 10.666 µM 0.596589167130979 0.312483780884522 no 1080 0.275390852763595 1326 432556
SGTC_2707 st078556 66.6 µM 0.594942730520597 0.312961344437241 no 1081 0.275940876515461 1344 17250899
SGTC_578 3460-0051 92 µM 0.59471076110303 0.313028654481067 no 1082 0.27601841369666 1391 2876744
SGTC_251 melphalan 456.522 µM 0.594419941886428 0.313113049642614 no 1083 0.276115636891326 1431 460612 A DNA alkylator.
SGTC_1980 st071811 45.7 µM 0.591875515236099 0.313851854421183 no 1084 0.276966975374335 1401 4974850
SGTC_2683 piperine 63.03 µM 0.5908277801941 0.314156294141866 no 1085 0.277317909686744 1323 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1915 st067105 30.6 µM 0.590171645918773 0.31434701109825 no 1086 0.277537789689505 1324 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2640 pentamidine 10.38 µM 0.589189689302391 0.314632526633971 no 1087 0.277867016505732 1376 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1994 st072947 40.9 µM 0.587186244194535 0.315215395808482 no 1088 0.27853931494425 1364 5286565 YDL195W SEC31
SGTC_1441 4106-0040 13 µM 0.587019513660184 0.315263924062834 no 1089 0.278595300600149 1345 2904180
SGTC_954 1189-0853 2.85 µM 0.585674385324796 0.315655550951168 no 1090 0.279047175218745 1341 2828194
SGTC_2332 7982454 138.89 µM 0.583424931453759 0.316310929956352 no 1091 0.279803639198828 1374 2981748
SGTC_1680 diphenhydramine 100 µM 0.580089378831748 0.3172838066683 no 1092 0.280927172930263 1385 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3283 9109332 35.8195 µM 0.579650745454897 0.317411836521402 no 1093 0.28107508245222 1310 17027281
SGTC_2873 9040596 71.43 µM 0.579403311855893 0.317484067950016 no 1094 0.281158534979599 1358 6463863
SGTC_1422 4031-0024 15.5 µM 0.578276374946409 0.31781313403824 no 1095 0.281538771005611 1308 782427
SGTC_621 3584-0052 32.1 µM 0.577410555740191 0.318066051433706 no 1096 0.281831072571355 1380 2273927
SGTC_3120 9124077 49.47 µM 0.575664647274543 0.31857631272098 no 1097 0.282420937684445 1401 18774327 YGL155W CDC43
SGTC_1679 SEC14.276 6.7 µM 0.575280419080907 0.318688653961388 no 1098 0.282550831040377 1417 1005053 YMR079W SEC14
SGTC_988 1497-1057 103 µM 0.574652762358353 0.31887220506177 no 1099 0.282763080347865 1398 3533044
SGTC_466 geldanamycin 89.2 µM 0.573912581295348 0.319088719728377 no 1100 0.283013479435082 1305 5288382 HSP90 inhibitor.
SGTC_2287 7945887 168.79 µM 0.573809112664243 0.319118990858831 no 1101 0.283048490768335 1398 1245853
SGTC_1327 1436-0082 2.18 µM 0.572355419596263 0.319544415629198 no 1102 0.283540605708127 1356 15992205
SGTC_591 4299-0174 154 µM 0.572098011688557 0.31961977109458 no 1103 0.283627788046957 1389 5509088
SGTC_2011 4012611 177 µM 0.571748896926878 0.319721985392408 no 1104 0.283746051399956 1358 2049887
SGTC_215 1287-0124 461.5 µM 0.570595626496132 0.320059738785741 no 1105 0.28413689191672 1449 5560863
SGTC_543 3844-1095 191 µM 0.569208286419745 0.320466240827718 no 1106 0.284607398933032 1440 4230703
SGTC_1637 st007924 17.4 µM 0.568468032391948 0.320683229534066 no 1107 0.284858603203231 1360 683336
SGTC_422 cantharidin 155 µM 0.566865306189971 0.321153242348398 no 1108 0.285402848470966 1327 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1274 0865-0114 173 µM 0.564769860366013 0.321768181613378 no 1109 0.286115154893214 1405 870624
SGTC_530 4358-1714 28 µM 0.564596515953896 0.321819073970802 no 1110 0.286174117788427 1433 1564641
SGTC_658 3253-0951 102 µM 0.561807226860869 0.32263844322083 no 1111 0.287123683855226 1416 1184878
SGTC_2403 6032726 181.2 µM 0.560375072942957 0.323059481632289 no 1112 0.287611815237363 1403 2881040
SGTC_1552 6-methylflavone 10.6 µM 0.555103950946926 0.324611087211854 no 1113 0.28941178025488 1378 689013
SGTC_1933 st074711 15.9 µM 0.554850419777398 0.324685793615788 no 1114 0.289498488449736 1365 17250958
SGTC_1291 0993-0025 5.79 µM 0.554205391969912 0.324875891617433 no 1115 0.289719144307658 1468 4353356
SGTC_1294 1000-1494 117 µM 0.54497168054562 0.327602164811906 no 1116 0.292886497486791 1374 712797 YDL207W GLE1
SGTC_1414 3917-0015 5.4 µM 0.544582629491417 0.327717236332048 no 1117 0.293020302145801 1410 6618702
SGTC_1287 0971-0001 34.6 µM 0.543949069686126 0.327904662410474 no 1118 0.293238260323154 1433 4665869
SGTC_2518 prenyletin 46.28 µM 0.543868551212018 0.327928485306914 no 1119 0.293265965789083 1371 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_660 4031-1742 102 µM 0.543219880196558 0.328120432292712 no 1120 0.293489210153372 1384 6738706
SGTC_3197 9113331 49.47 µM 0.542848269795941 0.328230415264254 no 1121 0.29361713775028 1502 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_835 0312-0010 67.2 µM 0.542614709967371 0.328299547979879 no 1122 0.293697554380599 1399 1626196
SGTC_2154 5570129 200 µM 0.541625850182991 0.328592311397451 no 1123 0.294038140081554 1411 673366
SGTC_1065 prochlorperazine maleate 2.48 µM 0.540643483443337 0.328883256694051 no 1124 0.294376670102012 1433 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1685 st024049 53.0905 µM 0.539787302466901 0.329136914444482 no 1125 0.294671862365486 1410 1941139
SGTC_319 1348-1596 45.5 µM 0.539119535401647 0.32933480608771 no 1126 0.294902188404494 1512 5380505
SGTC_2859 9028643 45.46 µM 0.539100617371359 0.32934041311085 no 1127 0.294908714814876 1390 17151580
SGTC_2352 9027995 87.8 µM 0.538977527255486 0.329376896129807 no 1128 0.294951180512788 1448 2997347
SGTC_309 k408-0051 1.48 µM 0.538280304902242 0.329583578438034 no 1129 0.295191773167104 1406 3640463
SGTC_1665 st014639 11.4 µM 0.537935976550604 0.329685669214653 no 1130 0.295310624925695 1483 981133 YIL048W NEO1
SGTC_937 3122-0005 46.7 µM 0.537757257921936 0.32973866295293 no 1131 0.295372321884288 1438 759535
SGTC_1214 0358-0031 63.7 µM 0.537471748020701 0.329823329585403 no 1132 0.295470897457655 1621 4301366
SGTC_305 1682-2595 20.8 µM 0.536793522673832 0.330024489109718 no 1133 0.295705123190798 1447 226033
SGTC_2057 5236571 38.335 µM 0.536311513856058 0.330167481307953 no 1134 0.295871637220025 1503 54684039 YBR257W POP4
SGTC_2141 5621638 7.665 µM 0.535353456663727 0.330451771134704 no 1135 0.29620273399008 1511 2856238
SGTC_49 0717-0965 32.132 µM 0.531156435619102 0.331698329045719 no 1136 0.297655189415798 1511 5889349 YGL099W LSG1
SGTC_1289 0976-0073 69.1 µM 0.530899358664359 0.331774744299147 no 1137 0.297744261112462 1474 3391136
SGTC_441 propafenone 146 µM 0.527856773963482 0.33267967320864 no 1138 0.298799374255064 1405 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1010 4112-3296 15.2 µM 0.52768985279672 0.332729347367991 no 1139 0.298857308622649 1508 704384
SGTC_2947 9072639 7.68 µM 0.526868745034479 0.332973744005005 no 1140 0.299142369874262 1392 16488146
SGTC_589 1227-0070 34.1 µM 0.52611264277511 0.33319885500306 no 1141 0.299404972472196 1449 2841384
SGTC_1670 st016595 4.04 µM 0.525426326712691 0.333403240907766 no 1142 0.299643428024883 1432 597879
SGTC_1224 0823-0416 294 µM 0.521233723718376 0.334652876325538 no 1143 0.301101982060009 1522 3598164
SGTC_1850 st056238 17 µM 0.520766692152358 0.33479219219401 no 1144 0.30126465435231 1436 5393177
SGTC_777 1315-0167 517 µM 0.520691252121794 0.334814698146013 no 1145 0.301290934667285 1404 4221767
SGTC_1178 0988-0033 191 µM 0.518608547331955 0.335436263526221 no 1146 0.30201687369932 1471 5392207
SGTC_2489 cantharidin 73.42 µM 0.516288507876706 0.336129190053111 no 1147 0.302826460734301 1415 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_892 0929-0076 29 µM 0.516236329042579 0.336144780728538 no 1148 0.302844679915671 1451 5751038
SGTC_669 0108-0021 26.2 µM 0.515110992802877 0.336481091979421 no 1149 0.303237730735281 1727 17201
SGTC_447 ml7 120 µM 0.514994958751827 0.336515776667722 no 1150 0.303278271393372 1546 4216 Selective myosin light chain kinase inhibitor.
SGTC_2625 euphol 100 µM 0.514701696463045 0.336603444299952 no 1151 0.303380743891956 1574 6708538 A triterpene alcohol.
SGTC_1163 k060-0048 49.9 µM 0.512075427601387 0.3373889347789 no 1152 0.304299110605962 1454 6809982
SGTC_203 k066-0004 30.888 µM 0.509055900707426 0.338292921146731 no 1153 0.305356520792885 1520 6795412
SGTC_3270 9137563 49.47 µM 0.506016031076555 0.339203940231566 no 1154 0.306422697877419 1517 17015724
SGTC_1968 st069590 43.6 µM 0.504822623376616 0.339561850290969 no 1155 0.306841712233314 1501 6384066
SGTC_782 0083-0095 30.5 µM 0.504811458383211 0.3395651994227 no 1156 0.306845633538833 1472 3591729 An indicator and reagent.
SGTC_2919 7978188 46.38 µM 0.50307137396591 0.340087322365985 no 1157 0.307457046008139 1557 2980291
SGTC_987 1497-1013 404 µM 0.501053842956723 0.340693078930139 no 1158 0.308166614962167 1480 1676435
SGTC_260 nsc-65238 3.989 µM 0.500474174108382 0.340867198547096 no 1159 0.308370618257955 1525 3246252
SGTC_828 2074-0507 139 µM 0.498223876166505 0.341543458951563 no 1160 0.309163127754739 1565 X828
SGTC_1547 harmine 94.2 µM 0.497606854960473 0.341728975410152 no 1161 0.309380585594624 1487 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2626 ethyl orsellinate 100 µM 0.496688872462988 0.342005051029535 no 1162 0.30970423529709 1450 75653 A natural product.
SGTC_701 4424-0219 185 µM 0.49647216770724 0.342070235519418 no 1163 0.309780659635681 1571 2911779
SGTC_2398 5228213 48.84 µM 0.492414893999012 0.343291525010737 no 1164 0.311213036193875 1605 80771 YMR134W ERG29
SGTC_2290 7904846 200 µM 0.491342969416795 0.343614461675044 no 1165 0.311591946673445 1483 2962154
SGTC_604 1000-0114 314 µM 0.491264381556376 0.343638142183867 no 1166 0.311619734250595 1591 1572745
SGTC_2988 9073640 71.4286 µM 0.490741429079457 0.343795736607219 no 1167 0.311804670307182 1531 9102229
SGTC_301 4119-0100 24.5 µM 0.490737100702639 0.343797041099183 no 1168 0.31180620118538 1507 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2435 5706476 10.6 µM 0.489665029740098 0.344120200511896 no 1169 0.312185475763796 1553 5725375
SGTC_1031 k035-0009 16 µM 0.488198865291389 0.344562337710457 no 1170 0.312704494106663 1619 5180959
SGTC_2126 5251174 33.877 µM 0.487952121702476 0.344636766716686 no 1171 0.312791877243096 1661 790722
SGTC_1074 carmofur 3.8 µM 0.485766151814731 0.345296416312685 no 1172 0.313566487724958 1514 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2891 9063876 19.48 µM 0.482937359321867 0.346150745205507 no 1173 0.314570107098798 1528 6472478
SGTC_57 miconazole 162.5 nM 0.480805248796519 0.346795186037056 no 1174 0.315327459728059 1436 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2300 7976697 71.57 µM 0.479765829339325 0.347109516578595 no 1175 0.315696956481756 1444 2236109
SGTC_2953 9074162 66.49 µM 0.479333588711611 0.347240261331188 no 1176 0.315850665287529 1646 16451992
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.47901496517341 0.347336650669146 no 1177 0.315963991188208 1441 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3196 9111891 49.47 µM 0.476778318625689 0.348013554018134 no 1178 0.316759993151261 1485 18891510
SGTC_2872 9044037 25.97 µM 0.476573558462352 0.34807554730306 no 1179 0.316832907893899 1598 6465195
SGTC_1325 1431-0015 227 µM 0.475372091481548 0.348439385783801 no 1180 0.317260891515847 1438 1103340
SGTC_3038 9091290 49.47 µM 0.473841535475588 0.348903083817995 no 1181 0.317806456501401 1566 25236843
SGTC_690 glyoxal 20.3 µM 0.473581401616807 0.348981916569033 no 1182 0.317899220305985 1427 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1545 lovastatin 49.4 µM 0.471738674478718 0.349540535717209 no 1183 0.318556664243788 1561 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_359 0081-0058 15.9 µM 0.469792415017144 0.350130894474046 no 1184 0.319251667012599 1677 3494159
SGTC_933 2914-0560 114 µM 0.469097133024189 0.350341882240283 no 1185 0.319500104129222 1677 463887
SGTC_3056 9094900 49.47 µM 0.467259970000864 0.350899603233237 no 1186 0.320156946196248 1448 25236784
SGTC_1052 3253-3998 198 µM 0.466988326174679 0.350982095436024 no 1187 0.320254115098556 1491 5450317
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.464670227564075 0.35168633590993 no 1188 0.321083816101212 1637 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2480 5767542 37.17 µM 0.464620207267555 0.35170153774319 no 1189 0.321101729388269 1589 2867358
SGTC_2101 5377231 179.231 µM 0.464499026781982 0.351738367087222 no 1190 0.321145128314431 1616 2844213
SGTC_1102 cgs 12066b 26.1 µM 0.462381381533014 0.352382189156148 no 1191 0.321903924284703 1534 6438352 A 5-HT1B full agonist.
SGTC_659 k018-0002 107 µM 0.461450902314014 0.352665214229549 no 1192 0.322237569406997 1627 6797879 YHR007C ERG11
SGTC_2566 crystal violet carbinol 226 nM 0.46005319900166 0.353090508720869 no 1193 0.322739017878779 1439 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2749 bexarotene 57.39 µM 0.458928506485075 0.353432864552115 no 1194 0.323142753581232 1497 82146 An retinoic acid receptor inhibitor.
SGTC_2100 5377183 190 µM 0.458543224095349 0.353550171607376 no 1195 0.323281108009037 1645 2844202
SGTC_3344 9148862 3.898 µM 0.458044276285033 0.353702107081026 no 1196 0.323460315872338 1620 4905352
SGTC_3055 9094636 49.47 µM 0.457286595881688 0.353932874234366 no 1197 0.323732531441871 1579 25236176
SGTC_1508 1080-0625 72.9 µM 0.457150704523347 0.353974268421469 no 1198 0.323781363779508 1530 767111
SGTC_2787 5284540 71.43 µM 0.457124679820568 0.353982196064491 no 1199 0.323790716060088 1550 736958
SGTC_2220 6782180 200 µM 0.457122872669366 0.353982746561106 no 1200 0.323791365485088 1550 833803
SGTC_1068 loratadine 26.9 µM 0.45374324881894 0.355012784632534 no 1201 0.325006817297376 1524 3957 A H1 histamine antagonist.
SGTC_89 0302-0250 142.109 µM 0.449948056759828 0.356170743175563 no 1202 0.326373947445379 1616 4203518 YLR208W SEC13
SGTC_1965 Pectolinarigenin 58.4 µM 0.449798752542792 0.356216324892123 no 1203 0.326427778707325 1527 5320438 An anti-inflammatory.
SGTC_2120 5538279 151.968 µM 0.446288131693131 0.357288688052461 no 1204 0.327694564088219 1583 2058197
SGTC_104 0074-0074 590.992 µM 0.445448106631827 0.357545451818149 no 1205 0.327997976804817 1542 3943124
SGTC_2146 5545642 200 µM 0.44356748369831 0.358120520506343 no 1206 0.328677659528945 1560 825326
SGTC_1546 5-methoxyflavanone 78.7 µM 0.442481027956589 0.358452890617892 no 1207 0.329070578042522 1638 147795
SGTC_1372 2752-0194 270 µM 0.438905309611926 0.359547535746512 no 1208 0.330365074643602 1506 823334
SGTC_2918 7977171 22.06 µM 0.438607080800815 0.359638885642302 no 1209 0.3304731327364 1543 2236483
SGTC_1807 st050092 58.9 µM 0.436051663249641 0.360421959009216 no 1210 0.331399623124572 1540 5008496
SGTC_856 0433-0016 11.3 µM 0.435643724200577 0.36054702075662 no 1211 0.331547620957134 1573 3911780
SGTC_386 1509-0011 3.07 µM 0.435589950825627 0.360563507156598 no 1212 0.331567131576641 1571 3107280
SGTC_904 1141-0088 396 µM 0.434104757458002 0.361018955513246 no 1213 0.332106185461711 1487 1378119
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.432792302671452 0.361421596073007 no 1214 0.332582832921645 1584 165521
SGTC_2182 6325192 200 µM 0.432627389064569 0.361472199849844 no 1215 0.332642744171773 1562 736248
SGTC_3254 9136651 49.47 µM 0.432385672235525 0.361546375091276 no 1216 0.332730564888673 1541 16454030
SGTC_2343 7990716 14.84 µM 0.431454147967301 0.361832279040135 no 1217 0.333069092708832 1621 6456862
SGTC_2906 7926292 26.41 µM 0.426774746304462 0.363269647649572 no 1218 0.334771701009927 1559 2966319
SGTC_146 3448-8650 53.125 µM 0.423386494601964 0.36431161909431 no 1219 0.336006648405294 1619 2891488 YIL048W NEO1
SGTC_1115 galangin 695.678 nM 0.422937053071225 0.364449909071616 no 1220 0.33617059394303 1651 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3087 9117406 49.47 µM 0.421880781647084 0.364774985747317 no 1221 0.336556019182765 1587 42546093
SGTC_3300 9124615 50.48 µM 0.421775448467161 0.364807408281257 no 1222 0.33659446386779 1666 24824903
SGTC_2691 st077356 60.2 µM 0.420731740823962 0.365128723434982 no 1223 0.336975490330229 1694 2839272
SGTC_2797 7859098 81.82 µM 0.419730293573879 0.365437117378644 no 1224 0.337341246116947 1585 972681
SGTC_1951 sophoraflavanone G 9.2 µM 0.419459327010129 0.365520576027984 no 1225 0.33744023692463 1560 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1207 2099-0101 141 µM 0.417501801377027 0.366123689698246 no 1226 0.338155703488227 1706 5837381
SGTC_3136 9095672 49.47 µM 0.417325818000095 0.366177926412223 no 1227 0.338220053290593 1694 17217380
SGTC_1391 3442-0225 151 µM 0.416910216168655 0.366306022289425 no 1228 0.338372040353796 1612 5227075
SGTC_2376 9072922 81.32 µM 0.416891245656888 0.366311869694249 no 1229 0.338378978565892 1629 17087968
SGTC_2201 6605497 169.863 µM 0.415081547044313 0.366869827463442 no 1230 0.339041103732163 1669 670741
SGTC_3314 9135860 59.4275 µM 0.410869651245694 0.368169507100749 no 1231 0.340584058541998 1719 25252478
SGTC_761 k216-0224 480 µM 0.410224837631618 0.36836861319811 no 1232 0.340820511253611 1779 1340404
SGTC_999 SEC7.066 22.7 µM 0.409024027612058 0.36873949452634 no 1233 0.341261014120339 1664 740511 YDR170C SEC7
SGTC_1518 st038567 90.8 µM 0.407122120564281 0.369327166292676 no 1234 0.341959148702579 1595 77966
SGTC_783 0848-0141 92.7 µM 0.407039467851424 0.369352712156057 no 1235 0.34198950037824 1580 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1691 st019933 84.6 µM 0.406797578506053 0.369427477349905 no 1236 0.342078332693427 1699 6176082
SGTC_2789 5281112 71.43 µM 0.404804075227932 0.370043833928984 no 1237 0.342810766510111 1555 765948
SGTC_153 4077-0274 519.67 µM 0.403960275870173 0.370304822706765 no 1238 0.343120965411337 1746 3121976
SGTC_731 3966-0296 387 µM 0.400896408283307 0.371252984183337 no 1239 0.344248197207073 1626 660956
SGTC_918 glabranin 770.725 nM 0.400470935418712 0.371384715341047 no 1240 0.34440484327734 1671 124049 Also referred to as licorice root.
SGTC_335 4077-0256 27.6 µM 0.399412952325597 0.371712344023522 no 1241 0.344794475891678 1710 3121989
SGTC_448 monastrol 171 µM 0.398121600336704 0.372112366660564 no 1242 0.345270276435086 1650 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_894 0960-0238 55.9 µM 0.397670058224718 0.372252273646265 no 1243 0.34543670556189 1654 6741907 YDL195W SEC31
SGTC_2061 5245884 80.95 µM 0.397510305705731 0.372301775822909 no 1244 0.345495594210615 1618 573863
SGTC_1460 k062-0059 9.15 µM 0.396024649780948 0.372762233853082 no 1245 0.346043421913938 1576 1373085
SGTC_801 0866-0028 10.1 µM 0.396004044430711 0.372768621470014 no 1246 0.346051022296229 1651 6849771
SGTC_1109 tnp00067 928.257 nM 0.39466302110103 0.373184411148707 no 1247 0.34654579841892 1623 676295
SGTC_3160 9100216 49.47 µM 0.393337129240322 0.373595654501927 no 1248 0.347035249240218 1634 17191039
SGTC_1880 MG-132 525 µM 0.391738102666448 0.374091805787706 no 1249 0.347625866869389 1719 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3139 9095020 49.47 µM 0.389382473286447 0.374823098198988 no 1250 0.348496617666767 1553 25236292
SGTC_2945 9067681 61.76 µM 0.388315736516695 0.375154409169655 no 1251 0.348891196571767 1666 16456930
SGTC_2183 6420625 130.508 µM 0.385791558040488 0.375938744195656 no 1252 0.349825523970672 1606 2897619
SGTC_2612 dictamnine 15.46 µM 0.385018721495584 0.37617898948094 no 1253 0.35011177251097 1652 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3205 9113483 49.47 µM 0.384254607776175 0.376416570354502 no 1254 0.350394873982398 1757 17018033
SGTC_3121 9125696 49.47 µM 0.383756514354902 0.376571464496584 no 1255 0.350579460627587 1711 1235365
SGTC_172 1112-0046 2.638 µM 0.383505397319031 0.376649562922537 no 1256 0.350672534566397 1663 2802135 YIL048W NEO1
SGTC_1160 4092-0570 10.5 µM 0.38329551830849 0.376714840027153 no 1257 0.35075033093345 1588 4994975
SGTC_277 nystatin 15.5 µM 0.381885286769285 0.377153545164134 no 1258 0.351273227079116 1611 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_48 0382-0018 55 µM 0.380469526186654 0.377594129869554 no 1259 0.351798456661985 1776 762596
SGTC_2293 7624732 200 µM 0.379058323645341 0.378033454675841 no 1260 0.352322276897002 1584 894453
SGTC_3192 9110362 49.47 µM 0.377771575623817 0.378434172783295 no 1261 0.352800145531545 1685 16649480
SGTC_2816 7982706 58.44 µM 0.377561053644536 0.378499745839447 no 1262 0.352878350689581 1643 2981853
SGTC_3052 9092717 49.47 µM 0.377525303934778 0.378510881450571 no 1263 0.352891631686245 1648 25237534
SGTC_2992 9074591 71.4286 µM 0.376742310943724 0.37875479977918 no 1264 0.353182558063221 1667 17741321
SGTC_531 3788-1495 174 µM 0.375496789468855 0.379142904683451 no 1265 0.353645516846809 1641 2896655
SGTC_3346 9158254 43.5805 µM 0.374918327956376 0.379323194945081 no 1266 0.353860603957769 1656 17639500
SGTC_2117 5521686 200 µM 0.374615627830299 0.379417548565219 no 1267 0.353973174374485 1628 803312
SGTC_396 dithiazanine 1.25 µM 0.373239820795416 0.379846487096293 no 1268 0.354484980657434 1633 10578 An antihelmenthic.
SGTC_245 methotrexate 289.6 µM 0.370833939160722 0.380596929464993 no 1269 0.355380610529487 1708 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.370458075121444 0.380714209610538 no 1270 0.355520604549954 1852 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_809 3998-0021 90 µM 0.368299125975237 0.381388074446954 no 1271 0.356325102082789 1785 715485
SGTC_3135 9127742 49.47 µM 0.367081824134445 0.381768185118939 no 1272 0.356778992298545 1649 3643468
SGTC_2887 9044784 58.44 µM 0.365488809062818 0.382265786973443 no 1273 0.357373279483981 1660 6465546
SGTC_2245 6637752 200 µM 0.364745135079543 0.382498151203991 no 1274 0.357650831674502 1817 681890
SGTC_9 0092-0002 10.449 µM 0.362949337274013 0.38305943048499 no 1275 0.358321365135928 1683 759368
SGTC_1987 st072290 61.9 µM 0.361143603720335 0.38362406286432 no 1276 0.358996049325766 1701 54697379
SGTC_128 0906-2981 13.371 µM 0.357414984803434 0.384790740688435 no 1277 0.36039058018652 1772 6740226
SGTC_1343 1487-0095 224 µM 0.356327982846874 0.385131058564379 no 1278 0.36079747775649 1802 4560101 YGL055W OLE1
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.354036247672095 0.385848843213311 no 1279 0.361655859253551 1716 65057 A dermal irritant. YDR527W RBA50
SGTC_2993 9054257 71.4286 µM 0.353825255207263 0.38591494696151 no 1280 0.361734922680089 1656 6470217 YGL055W OLE1
SGTC_1522 st012842 45.6 µM 0.352418751037972 0.386355688004773 no 1281 0.362262120797535 1586 3491067 YOR116C RPO31
SGTC_1317 1273-0028 910 nM 0.351278277969941 0.386713173461099 no 1282 0.362689794769688 1684 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3158 9100007 49.47 µM 0.351030965958566 0.386790707011865 no 1283 0.362782558657463 1649 19297233
SGTC_2773 thioridazine 9.09 µM 0.348834310298622 0.387479567501123 no 1284 0.363606851775902 1731 5452 An antipsychotic.
SGTC_2949 9072542 2.23 µM 0.34769813482969 0.38783600578031 no 1285 0.364033448782054 1645 16457352
SGTC_3134 9127454 49.47 µM 0.347499852921955 0.387898220007796 no 1286 0.364107914490463 1730 24262820
SGTC_1608 st001473 40.5 µM 0.345751432862016 0.388446940108893 no 1287 0.364764763729102 1646 7292267
SGTC_3206 9114350 49.47 µM 0.34516216948013 0.388631923395082 no 1288 0.364986228716136 1694 17087243
SGTC_975 1335-0046 28.5 µM 0.341457170875762 0.389795584473555 no 1289 0.366379721068 1615 16486740
SGTC_2067 5224629 34.075 µM 0.341201804937316 0.389875826003798 no 1290 0.366475832293899 1668 2835000
SGTC_518 1021-0119 62.6 µM 0.340788797455254 0.390005611867101 no 1291 0.366631292264076 1646 1097762
SGTC_1084 voriconazole 435 nM 0.340145615951983 0.390207753362206 no 1292 0.366873435504162 1834 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_907 3448-6986 75.5 µM 0.33907437185107 0.390544493853976 no 1293 0.36727685216015 1818 590582
SGTC_3117 9124945 49.47 µM 0.339046785350192 0.390553166625032 no 1294 0.367287242816591 1630 17592065
SGTC_421 streptovitacin 30 mM 0.338174065690303 0.390827564335711 no 1295 0.367616009164633 1694 91467 include heat shock
SGTC_297 0986-0032 24 µM 0.33759582980941 0.39100940135661 no 1296 0.367833892599938 1708 2847425
SGTC_508 roscovitine 141 µM 0.334963959975613 0.391837342255658 no 1297 0.368826136518734 1781 160355 A CDKinase inhibitor.
SGTC_1892 st058411 7.36 µM 0.331650646191213 0.392880350151647 no 1298 0.370076535909572 1829 3934738
SGTC_583 1488-1091 88.9 µM 0.331437505885945 0.392947471646665 no 1299 0.370157019344581 1867 4303273
SGTC_2302 7771753 200 µM 0.33030471280182 0.393304260760909 no 1300 0.370584866146253 1659 2203047
SGTC_1041 0206-0046 107 µM 0.329226886911922 0.393643820400081 no 1301 0.370992100940255 1726 50494
SGTC_3279 9140807 49.47 µM 0.327794114302605 0.394095328108583 no 1302 0.371533668893681 1724 45595718
SGTC_1297 1068-0111 14.1 µM 0.327501599579008 0.394187525400342 no 1303 0.371644266661567 1681 767057
SGTC_2032 5185112 25.99 µM 0.326994838557451 0.394347264703696 no 1304 0.37183589452757 1775 5718189
SGTC_1857 st056007 79.3 µM 0.324976524889464 0.394983646027059 no 1305 0.372599419327987 1835 619834
SGTC_3098 9119039 49.47 µM 0.324635779583762 0.395091111904829 no 1306 0.372728372230166 1735 17161528
SGTC_1515 3460-0031 42.1 µM 0.322804640351902 0.395668761805429 no 1307 0.373421599251578 1800 2876596
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.320458436784029 0.396409228442942 no 1308 0.374310416492073 1710 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1428 4049-0204 61.7 µM 0.320361838725804 0.396439723017506 no 1309 0.374347025296811 1837 X1428
SGTC_1468 k284-1086 134 µM 0.319766069320072 0.396627812580452 no 1310 0.374572835463355 1746 15996457
SGTC_2512 diallyl trisulfide 49.23 µM 0.319715905352919 0.396643650878129 no 1311 0.374591850713575 1763 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2817 7995342 71.43 µM 0.319430838698619 0.396733658371107 no 1312 0.374699914419334 1651 18879975
SGTC_1079 idarubicin 2.36 µM 0.319203029279106 0.396805591310566 no 1313 0.374786279998986 1845 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1198 1612-1005 86.7 µM 0.319114987039225 0.396833392406247 no 1314 0.374819659665521 1845 6998509
SGTC_3074 9116018 49.47 µM 0.318262547803062 0.397102594217082 no 1315 0.375142895470661 1748 17027303
SGTC_1793 st048256 72.231 µM 0.317136822994478 0.397458175206426 no 1316 0.375569892585228 1765 672022
SGTC_1605 st000082 49.1 µM 0.316941750789321 0.397519801040562 no 1317 0.375643900665753 1821 1114022
SGTC_1881 5652484 16 µM 0.316710905248373 0.397592731438821 no 1318 0.375731486636752 1865 2255129
SGTC_1762 st045503 25.4615 µM 0.316645398701273 0.3976134273946 no 1319 0.375756341887652 1726 4645554
SGTC_2888 9058547 12.99 µM 0.316095103666148 0.397787297447019 no 1320 0.375965161535282 1691 16476514
SGTC_2196 6573537 42.6665 µM 0.3156906048756 0.397915114977014 no 1321 0.376118679264395 1852 2903087
SGTC_2756 carbadox 75.1 µM 0.313667188125124 0.398554658463409 no 1322 0.376886912002205 1736 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3222 9128301 49.47 µM 0.312737482755464 0.398848602914306 no 1323 0.377240057911386 1734 4911358
SGTC_1296 1068-0102 11.9 µM 0.309303889360637 0.39993469636042 no 1324 0.37854518632774 1840 767053
SGTC_1404 3909-7820 48.3 µM 0.309116976202926 0.399993841901972 no 1325 0.378616273011567 1861 23741373
SGTC_1846 st056244 14.8 µM 0.304952105682853 0.401312338211011 no 1326 0.380201314995122 1813 5393182
SGTC_1057 3448-5381 134 µM 0.303624002386411 0.401733020481209 no 1327 0.380707181545802 1877 5497911
SGTC_2427 5545055 42.75 µM 0.303328627389786 0.401826597245347 no 1328 0.380819715866808 1801 5372858
SGTC_417 st075190 100 µM 0.30260407261947 0.402056164845152 no 1329 0.381095805203943 1908 222757
SGTC_2007 4011539 71.82 µM 0.300986995524082 0.402568640569365 no 1330 0.381712205529774 1721 45595301
SGTC_2208 7283366 200 µM 0.299643810832626 0.402994443097558 no 1331 0.382224431274911 1879 898663
SGTC_1877 wortmannin 25 µM 0.298915557010843 0.403225354735363 no 1332 0.382502238357645 1874 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1914 st062367 72.6 µM 0.29875057725964 0.403277670507761 no 1333 0.382565181612955 1749 978205
SGTC_2814 7977482 42.97 µM 0.295806057939277 0.404211680277159 no 1334 0.383689098183582 1888 6456762
SGTC_3232 9132874 49.47 µM 0.295089807930082 0.404438959589599 no 1335 0.383962637670465 1736 3784940
SGTC_524 r073-0010 27.8 µM 0.294764677946239 0.404542139965966 no 1336 0.38408682553754 1743 2772106
SGTC_1425 4048-4433 7.33 µM 0.293880622779964 0.404822729443457 no 1337 0.384424562708327 1876 23734946
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.292211088198819 0.405352754914505 no 1338 0.385062617140482 1885 165506
SGTC_3065 9113888 49.47 µM 0.292126568195268 0.405379592020648 no 1339 0.385094926869381 1864 16648368
SGTC_1787 fluconazole 80 µM 0.290959957001082 0.405750064143977 no 1340 0.385540972424249 1805 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2858 9025781 8.96 µM 0.289300519733779 0.406277184808307 no 1341 0.386175707312175 1906 4894980 YPL153C RAD53
SGTC_1521 st012942 49.4 µM 0.288234151130931 0.406616006801567 no 1342 0.38658375435247 1957 24207259
SGTC_2491 paeonol 100 µM 0.287623335467821 0.406810115465943 no 1343 0.386817540123719 1779 11092 Increases levels of cortical cytochrome oxidase.
SGTC_860 0443-0016 25.1 µM 0.285982130597574 0.407331780674031 no 1344 0.387445903980216 1877 5337942
SGTC_1108 betulinic acid 729.144 nM 0.285545501580984 0.407470593124045 no 1345 0.387613124744705 1780 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3163 9099914 49.47 µM 0.28485857721747 0.407689002613927 no 1346 0.387876246148348 1877 16268368
SGTC_2459 5811157 9.22 µM 0.283452346170196 0.408136207068465 no 1347 0.388415053245296 1878 2870684 YBR192W RIM2
SGTC_1671 st016596 74.5 µM 0.282995942519503 0.408281376643134 no 1348 0.388589973663555 1805 2829167
SGTC_2776 terbinafine 19.92 µM 0.282667179942175 0.408385954869021 no 1349 0.388715988601801 1838 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1055 3448-0672 86 µM 0.282630060240553 0.408397762926352 no 1350 0.388730217346814 1814 748378
SGTC_2525 harmine 47.85 µM 0.282306514532367 0.40850068877956 no 1351 0.38885424538975 1870 5280953 A monoamine oxidase inhibitor
SGTC_366 0181-0206 4.31 µM 0.281990707558937 0.408601158885948 no 1352 0.38897531779135 1963 274874
SGTC_2650 prasterone 100 µM 0.281186257592984 0.408857111879253 no 1353 0.389283772239641 1858 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1902 st060212 70.5 µM 0.281014804278712 0.40891166845394 no 1354 0.389349522505924 1851 688944
SGTC_1896 st058441 89 µM 0.279386792223655 0.40942979091972 no 1355 0.38997400298633 1780 688759
SGTC_1381 2324-0066 62.1 µM 0.278331786118643 0.409765636113498 no 1356 0.390378838969431 1830 10885928
SGTC_2091 4-phenylthiadiazole 200 µM 0.277979385421713 0.409877832296088 no 1357 0.390514091694891 1808 270010
SGTC_594 1487-1584 10.8 µM 0.276576578561329 0.410324526428052 no 1358 0.391052625494154 1743 5013332
SGTC_108 0509-0257 621.132 µM 0.276307367170212 0.410410264420226 no 1359 0.391155998958019 1907 536624
SGTC_3244 9134489 49.47 µM 0.275422225877558 0.410692192897038 no 1360 0.391495935183749 1793 16584271
SGTC_2312 7706453 155.7 µM 0.274309235561942 0.411046759592978 no 1361 0.391923493838988 1797 976098
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.272293791673107 0.4116890068284 no 1362 0.392698064735318 1856 688801
SGTC_27 0485-0001 32.618 µM 0.270979982425249 0.412107796656241 no 1363 0.393203214081429 1931 2054479
SGTC_2925 9010536 32.5 µM 0.27071869846786 0.412191095478639 no 1364 0.393303697181697 1879 2994177
SGTC_420 mitomycin C 81.9 mM 0.270695462521321 0.412198503423107 no 1365 0.393312633474289 1816 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2583 asiatic acid 100 µM 0.27069318186682 0.412199230529319 no 1366 0.393313510592262 1847 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2778 tioconazole 65.09 nM 0.270184138746165 0.412361528502501 no 1367 0.39350929726296 1796 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1076 itraconazole 331 nM 0.269685378521382 0.412520562521605 no 1368 0.393701155075701 1907 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2653 dihydrofissinolide 100 µM 0.269213385457849 0.412671074827221 no 1369 0.393882740148225 1862 6857746
SGTC_2904 7225135 42.03 µM 0.268682311367076 0.412840442637909 no 1370 0.394087082447533 1958 4446116
SGTC_304 1310-0298 97 µM 0.266291538261331 0.413603097978684 no 1371 0.395007344699613 1850 1550234
SGTC_3230 9131665 49.47 µM 0.265550377535469 0.413839594193537 no 1372 0.395292753338325 1864 15943720
SGTC_3132 9126706 49.47 µM 0.264572820854714 0.414151569533556 no 1373 0.39566928000769 1869 850858
SGTC_2234 tolnaftate 200 µM 0.264539879465719 0.4141620833224 no 1374 0.395681969779844 1923 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3169 9102970 49.47 µM 0.261753598703595 0.415051592802239 no 1375 0.396755707447474 1885 17027839
SGTC_2022 5136654 200 µM 0.261248874913913 0.415212770680519 no 1376 0.396950294831429 1856 1713771
SGTC_2819 7996655 46.38 µM 0.260914983190926 0.415319403099572 no 1377 0.397079035020259 1928 6456960
SGTC_2059 5238311 157 µM 0.260499443328683 0.415452119564723 no 1378 0.397239272326793 1815 703021
SGTC_2432 5630864 12.22 µM 0.26038207246249 0.415489607599298 no 1379 0.397284535126209 1824 5714970
SGTC_1164 k060-0068 93.7 µM 0.257660423776762 0.416359112132012 no 1380 0.398334496111397 1856 5963676
SGTC_2984 9022109 38.96 µM 0.257418982561956 0.416436266915859 no 1381 0.398427675276069 2013 6459207
SGTC_838 0109-0203 71.4 µM 0.256405073864014 0.416760305979536 no 1382 0.398819035204759 1853 759422
SGTC_534 k292-0788 63.4 µM 0.255237732442008 0.417133451251748 no 1383 0.399269744823802 2020 4146317
SGTC_950 1165-0508 94.1 µM 0.254826574465325 0.417264897309774 no 1384 0.399428524613641 1804 6148369
SGTC_454 lyso-paf C-16 6.67 µM 0.254181733435265 0.417471069807253 no 1385 0.399677580942151 1765 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2269 7935389 174.42 µM 0.25283702034666 0.417901082590718 no 1386 0.400197079402317 1787 97605
SGTC_1147 3809-1045 12.3 µM 0.251396849789084 0.418361729659138 no 1387 0.400753651512135 1839 325925
SGTC_1000 4048-0884 8.67 µM 0.24980163512067 0.418872099208609 no 1388 0.401370377592792 1878 13040088
SGTC_3131 9127911 49.47 µM 0.249126673435429 0.419088086165266 no 1389 0.401631398678841 1896 45595681
SGTC_800 3448-7362 155 µM 0.248722758252518 0.419217350223245 no 1390 0.401787621701069 1897 15991913
SGTC_521 r062-0005 13.8 µM 0.244538762395954 0.420556855405967 no 1391 0.403406792478223 1831 2832033
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.241794868354818 0.421435813122071 no 1392 0.404469557705099 1935 688761
SGTC_657 3534-0529 86.7 µM 0.241048052853744 0.421675110186849 no 1393 0.404758936764295 1969 1049549
SGTC_1293 1000-1278 195 µM 0.240678128279739 0.421793653346862 no 1394 0.404902295922605 1936 678847
SGTC_355 1311-2252 105 µM 0.240488389925016 0.42185445817888 no 1395 0.404975831354437 1843 5338538
SGTC_1613 st002381 52.1 µM 0.239658849858269 0.422120320039367 no 1396 0.405297369176431 2016 551167
SGTC_768 0384-0033 77.3 µM 0.238891742728842 0.422366204164035 no 1397 0.405594764281526 1817 3965305 YMR134W ERG29
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.238514183263004 0.422487236029367 no 1398 0.40574115804342 1941 16623 A steroid.
SGTC_2111 5486399 200 µM 0.238050939666759 0.422635745115506 no 1399 0.40592079271935 1862 689674
SGTC_3011 9081274 71.4286 µM 0.235352033925463 0.423501192632734 no 1400 0.406967755929822 1859 6625322
SGTC_632 0781-2353 4.65 µM 0.235141044629553 0.423568865355215 no 1401 0.407049631315116 1931 6811515 YHR007C ERG11
SGTC_2028 5153890 36.43 µM 0.234743166485581 0.423696486953495 no 1402 0.407204040844047 1886 2830968 YPR165W RHO1
SGTC_3013 9080133 71.4286 µM 0.234614882253417 0.423737636532022 no 1403 0.407253828780252 1927 17050193
SGTC_408 cantharidin 100 µM 0.23305530604988 0.424237966293001 no 1404 0.407859229959398 1910 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1956 st077085 54 µM 0.231294770372924 0.42480291284151 no 1405 0.40854290459401 1858 24208685
SGTC_2280 7785178 200 µM 0.230958528555605 0.424910828660908 no 1406 0.408673510219981 1892 2954328
SGTC_2238 6671620 73.2395 µM 0.230859757276836 0.424942530081179 no 1407 0.408711877645739 1876 729941
SGTC_36 0335-0881 14.2 µM 0.230850884312018 0.424945377952923 no 1408 0.408715324366828 1903 23828853
SGTC_2222 6885208 172.143 µM 0.229342969770958 0.425429415825705 no 1409 0.409301179154188 1940 609514
SGTC_1220 1838-0075 193 µM 0.22711622576622 0.42614440204152 no 1410 0.410166683682166 1949 5529645
SGTC_569 4130-2812 160 µM 0.226149041069112 0.426455031586789 no 1411 0.410542751589571 2042 743552
SGTC_785 1270-0111 65.3 µM 0.225201750648131 0.426759315942215 no 1412 0.410911163804331 1968 6741994
SGTC_2774 tamoxifen 10.92 µM 0.225119232678881 0.426785824058655 no 1413 0.41094325972441 1947 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2684 capsaicin 100 µM 0.22280925430049 0.427528016509552 no 1414 0.411841982581551 1942 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2534 helenine 20.12 µM 0.222055087170636 0.427770384911883 no 1415 0.412135500124802 1876 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1014 4130-3005 69.3 µM 0.220734286089083 0.428194919369969 no 1416 0.412649666708375 1860 743608
SGTC_1319 1306-0155 43.7 µM 0.216661626735039 0.429504482691265 no 1417 0.414236027528701 1949 3122360
SGTC_318 1488-0629 67.2 µM 0.216124080782479 0.429677388845963 no 1418 0.414445514756265 1904 3662576
SGTC_2997 9067075 71.4286 µM 0.216020358954461 0.429710753393679 no 1419 0.414485939030395 1954 27209819
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.215131598550228 0.429996664485366 no 1420 0.414832359276355 2041 1241132 A phosphatase inhibitor.
SGTC_2915 7971052 15.16 µM 0.215033940511343 0.430028082973828 no 1421 0.414870428384557 2018 5741558
SGTC_1709 st033179 39.1045 µM 0.213794122300013 0.430426995033088 no 1422 0.415353804356828 1927 573381
SGTC_2712 st079126 47.7 µM 0.213059037953551 0.430663542306699 no 1423 0.415640457017846 1925 3152970
SGTC_199 4063-0024 41.6 µM 0.211947267528929 0.4310213529343 no 1424 0.416074087012448 2016 306215
SGTC_213 1246-0773 967 nM 0.211377741216247 0.431204670432175 no 1425 0.416296262139384 1972 6251622
SGTC_1481 3346-2004 36 µM 0.211345996542422 0.431214888753269 no 1426 0.416308646686618 2031 2770522
SGTC_2592 piperlongumine 83.33 µM 0.210412809493995 0.431515293697362 no 1427 0.416672747952602 1874 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_767 0929-0023 86 µM 0.208921435494461 0.431995468393283 no 1428 0.417254785143995 2019 1204563
SGTC_682 0kpi-0099 17 µM 0.208634730921942 0.432087789626471 no 1429 0.417366697904204 1894 1714895 YML126C ERG13
SGTC_2265 7929201 200 µM 0.208106678975589 0.432257836403338 no 1430 0.417572836129932 1891 1265108
SGTC_3062 9077494 49.47 µM 0.208095253668769 0.432261515794949 no 1431 0.417577296533519 1996 16459633
SGTC_1292 0kpi-0043 232 µM 0.207764854651985 0.43236791962386 no 1432 0.417706287848264 1923 3333905
SGTC_2912 7964298 10.93 µM 0.205998437428433 0.432936871042563 no 1433 0.418396065941117 1909 2975850
SGTC_1905 st060207 84.5 µM 0.205590108448166 0.433068410961911 no 1434 0.418555552395391 1921 1948547
SGTC_1174 0739-0097 51.1 µM 0.205554172326753 0.433079987851638 no 1435 0.418569589083364 1930 728447
SGTC_2473 5854593 8.94 µM 0.205426502960256 0.433121117244775 no 1436 0.418619457714698 1906 2872951
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.205412674253951 0.433125572282552 no 1437 0.418624859391702 2049 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1553 gossypol 38.6 µM 0.205082964407391 0.433231793687324 no 1438 0.41875365299436 2018 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1600 coumarin 106 71.1 µM 0.203324891573126 0.433798266775953 no 1439 0.419440550595455 1970 100336 A hepatotoxic, DNA x-linker.
SGTC_1373 2887-0003 58.5 µM 0.203212648034534 0.433834437680929 no 1440 0.419484413691608 1928 776948
SGTC_1581 himbacine 57.9 µM 0.203018455972082 0.433897018116141 no 1441 0.419560303407787 1902 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2603 homopterocarpin 100 µM 0.202893176236541 0.433937391708362 no 1442 0.419609263966797 1919 101795 A weak amylase inhibitor.
SGTC_3155 9099265 49.47 µM 0.199932672365562 0.434891665680527 no 1443 0.420766618717688 1986 25236499
SGTC_1218 1348-1416 30.7 µM 0.199198995314041 0.435128214338397 no 1444 0.421053542648654 1935 6787668
SGTC_766 1391-0721 126 µM 0.198528375123701 0.435344452816933 no 1445 0.421315843204922 2033 1020919 YIL115C NUP159
SGTC_354 2783-3500 4.88 µM 0.198398056384286 0.435386475756893 no 1446 0.421366819000999 1872 6740761
SGTC_1282 0886-0010 32.4 µM 0.19829405986255 0.435420011285501 no 1447 0.421407499479787 2068 2836211 YNL267W PIK1
SGTC_2334 9017922 200 µM 0.197314786677778 0.435735818091435 no 1448 0.421790604356711 2031 3163164
SGTC_182 3448-4371 550.524 µM 0.196254765833454 0.436077711479562 no 1449 0.422205382237145 2134 3491403
SGTC_3340 9146634 11.102 µM 0.195299905361461 0.436385727914981 no 1450 0.422579085577434 1944 4907387
SGTC_948 3448-0295 75.3 µM 0.19488364462488 0.436520016318758 no 1451 0.422742019199954 1964 678569
SGTC_1477 0139-0234 16 µM 0.193301356034879 0.437030539478809 no 1452 0.423361482197503 2037 620880
SGTC_1410 3909-8106 77.9 µM 0.193135834829231 0.437083950734136 no 1453 0.423426294411311 2070 1039210
SGTC_2654 protoveratrine a 100 µM 0.191091895496988 0.437743594068818 no 1454 0.424226798548389 1999 5702278 A heart drug and vasodilator.
SGTC_2405 ticlatone 3.52 µM 0.190588358179199 0.437906127994436 no 1455 0.424424055915036 1954 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1326 1431-2094 10.8 µM 0.188625780597576 0.438539716908821 no 1456 0.425193062761552 1896 616278
SGTC_2549 cedrol 20.94 µM 0.187928934046837 0.438764721413933 no 1457 0.425466180368037 2068 6708665 A sedative which affects the nervous system.
SGTC_3265 9137266 49.47 µM 0.187813292971923 0.438802062631155 no 1458 0.425511507459581 2124 17224265
SGTC_229 benomyl 22.8748 µM 0.187190422274117 0.439003200786141 no 1459 0.425755667015059 1981 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2669 eugenol 100 µM 0.18555233295101 0.43953224961363 no 1460 0.42639791853875 2085 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1331 1472-0049 76.2 µM 0.184492661566147 0.439874546119391 no 1461 0.426813491785319 1932 24051409
SGTC_481 bay k-8644 50 µM 0.183251664693926 0.440275471759576 no 1462 0.427300279042195 1938 2303 A calcium channel antagonist.
SGTC_2409 alverine citrate 63.97 µM 0.183086548280759 0.44032882011604 no 1463 0.427365055145836 2039 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_18 0111-0177 500 nM 0.182438438712893 0.440538231809049 no 1464 0.427619331110843 2004 721752
SGTC_2166 5933061 31.504 µM 0.181354403514908 0.440888533256606 no 1465 0.428044703041587 2051 2877375
SGTC_178 4092-0806 87.505 µM 0.181139054558509 0.440958127888747 no 1466 0.428129215253361 2070 2169044
SGTC_584 0986-0246 15.4 µM 0.181095796569555 0.440972107855284 no 1467 0.428146191950341 2098 53315 YDR232W HEM1
SGTC_3276 9139060 49.47 µM 0.180835285938279 0.441056300330543 no 1468 0.428248432756125 2037 4870619
SGTC_2635 hydroquinidine 100 µM 0.180179878651782 0.44126812826519 no 1469 0.428505677208581 1972 442912 An experimental heart treatment.
SGTC_3104 9120930 49.47 µM 0.17919651895911 0.44158598206616 no 1470 0.428891698477905 2006 17014836
SGTC_1449 4112-4002 201 µM 0.178781620755457 0.441720101942503 no 1471 0.429054588638785 1914 2059539
SGTC_2488 5268135 45.7 µM 0.1782468424389 0.44189298408563 no 1472 0.429264561877785 2029 1270356 YLR208W SEC13
SGTC_2721 ifenprodil 61.44 µM 0.177763195359165 0.44204934615053 no 1473 0.429454476389131 2070 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.177364119208191 0.442178373415754 no 1474 0.429611194589023 1939 6708784 An antioxidant flavonoid
SGTC_683 panaxydol 45 µM 0.174726718466818 0.443031237968557 no 1475 0.43064718620974 2069 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1015 4130-4525 82 µM 0.174438675710809 0.443124399321092 no 1476 0.430760360704815 1913 1363237
SGTC_1246 0422-0085 105 µM 0.17273824762283 0.443674430811776 no 1477 0.431428589209376 2115 264295
SGTC_1241 0364-0022 50.8 µM 0.172370150894896 0.443793512091124 no 1478 0.431573268533674 2023 4563895
SGTC_204 PMA1.184 62.41 µM 0.170741749360433 0.444320369524253 no 1479 0.43221341678773 2102 2252213 YGL008C PMA1
SGTC_284 0988-0104 32.6 µM 0.170541499047341 0.444385165864958 no 1480 0.432292150413761 2090 4666532
SGTC_752 1896-0090 130 µM 0.166370578675995 0.445735113960884 no 1481 0.433932663036775 2038 772567
SGTC_2446 5162541 200 µM 0.16599073966502 0.445858083064922 no 1482 0.434082118876514 1978 1549321
SGTC_1489 4065-0444 182 µM 0.165977002850587 0.445862530319698 no 1483 0.4340875240987 2117 2877968
SGTC_2127 5253358 187.912 µM 0.162753399603024 0.446906349897496 no 1484 0.435356300332807 1998 20612
SGTC_3310 9130229 44.1445 µM 0.162096902487775 0.447118972423655 no 1485 0.435614772698078 2091 7761258
SGTC_2365 9042475 200 µM 0.161535186317085 0.447300909909306 no 1486 0.435835950281964 1995 6464479
SGTC_2506 ethyl hematommate 54.16 µM 0.161077802712049 0.447449062712688 no 1487 0.436016061403602 1929 3940691 An allergen.
SGTC_599 1935-0052 86.5 µM 0.158622214717977 0.448244586088459 no 1488 0.43698326278705 2087 9557311
SGTC_1210 3013-0140 750 nM 0.156559098880432 0.448913123477491 no 1489 0.437796169653711 2159 905973
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.155002989466847 0.449417465277279 no 1490 0.438409480269005 2046 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3252 9135871 49.47 µM 0.154488744176183 0.449584152409861 no 1491 0.438612192762145 2102 17682838
SGTC_3243 9134147 49.47 µM 0.153667164655286 0.449850477107821 no 1492 0.438936088013017 2144 24282180
SGTC_11 0438-0307 1.3 µM 0.152282912679678 0.450299249754505 no 1493 0.439481900720606 2153 4011476
SGTC_694 1315-0438 43.2 µM 0.151944777301558 0.450408882474485 no 1494 0.439615245552443 2073 6793154
SGTC_1865 st057639 52.2 µM 0.151178342880579 0.450657395432695 no 1495 0.439917516903634 2150 688818
SGTC_1050 3232-1156 69.3 µM 0.151076848710932 0.450690305919223 no 1496 0.439957547458982 1999 700529
SGTC_677 0929-0063 136 µM 0.149706401524767 0.451134720052782 no 1497 0.440498128708507 2153 1539583
SGTC_2911 7942208 15.64 µM 0.148710418408794 0.451457739939834 no 1498 0.440891069977206 1999 1243384
SGTC_1211 1056-0033 32.3 µM 0.147751884282523 0.451768644628076 no 1499 0.441269291611507 2157 6741922
SGTC_313 3474-0040 5.03 µM 0.14666785618686 0.452120289465322 no 1500 0.441697095611228 2059 1043375 YIL048W NEO1
SGTC_177 1327-0068 8.361 µM 0.146475623106329 0.452182651344953 no 1501 0.441772966148039 2150 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3329 9141233 27.5565 µM 0.145417228727963 0.452526023653526 no 1502 0.442190731344123 2119 4909101 YNL103W MET4
SGTC_1937 st074714 47.2 µM 0.144796761861597 0.452727336732693 no 1503 0.44243566947117 2044 17250970
SGTC_2960 9079389 5.97 µM 0.143943549111656 0.453004185024606 no 1504 0.442772523267137 2143 16457355
SGTC_3157 9099274 49.47 µM 0.142478624368229 0.453479573270917 no 1505 0.443350981197459 2160 17217662
SGTC_664 1222-0054 14.9 µM 0.142185072111156 0.453574843059773 no 1506 0.443466911359349 2105 6813991
SGTC_2372 9071633 200 µM 0.142036566155316 0.453623040372385 no 1507 0.443525561430459 2184 21321366
SGTC_1252 0493-0875 34.8 µM 0.140740387649459 0.454043741450666 no 1508 0.444037518949472 2063 3960963
SGTC_1953 st076800 12.1 µM 0.140519211360432 0.454115533873991 no 1509 0.444124887306204 1933 297591
SGTC_75 0159-0059 199.013 µM 0.138933868601733 0.454630169843029 no 1510 0.444751203612811 2144 5377270
SGTC_759 3486-0358 89.3 µM 0.138535484405792 0.454759505832694 no 1511 0.444908613737923 2195 875103
SGTC_511 blebbistatin 171 µM 0.138392517005821 0.454805921570385 no 1512 0.444965105338133 2149 3476986 A myosin inhibitor.
SGTC_3113 9123498 49.47 µM 0.138130252275955 0.454891069934264 no 1513 0.445068738541232 2192 8897275
SGTC_729 4092-0585 94.1 µM 0.138096074408707 0.454902166468422 no 1514 0.445082244110272 2028 2169061
SGTC_1019 4262-0212 3.4 µM 0.137365090292143 0.455139503620852 no 1515 0.445371111672082 2172 4677213
SGTC_2448 5185112 27.17 µM 0.136646897409475 0.455372703289845 no 1516 0.445654952693111 2039 5718189
SGTC_2452 5863136 48.41 µM 0.136360826918426 0.45546559563727 no 1517 0.445768019975841 2136 2184096
SGTC_2875 9039966 71.43 µM 0.135739119348221 0.455667483903432 no 1518 0.446013760571706 2127 6463691
SGTC_2931 9014674 55.67 µM 0.135439881728895 0.455764659981567 no 1519 0.446132046779565 2110 2996810
SGTC_2317 5986382 200 µM 0.134655461486993 0.45601940949219 no 1520 0.446442144478102 2131 877883
SGTC_2206 7254556 146.969 µM 0.133688971100759 0.456333313232354 no 1521 0.446824263329057 2155 4398905
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.131972593033913 0.456890837973389 no 1522 0.447502984850043 2162 3256 An antibiotic and ribosome inhibitor.
SGTC_2174 5790901 200 µM 0.131625085616653 0.457003727888779 no 1523 0.44764042135169 2071 786020
SGTC_679 0422-0091 41.4 µM 0.127489090104279 0.458347595279048 no 1524 0.449276653779164 2101 627384 YHR062C RPP1
SGTC_3267 9137951 49.47 µM 0.12710825469104 0.458471360474783 no 1525 0.449427359080094 2037 16643986
SGTC_896 0964-0007 44.5 µM 0.126650605788583 0.45862009410613 no 1526 0.449608470888203 2199 6756758
SGTC_1400 3771-8998 51.5 µM 0.126558195654455 0.458650127646662 no 1527 0.449645042919595 2138 670767
SGTC_342 k048-0088 23.3 µM 0.125973287798302 0.458840229731132 no 1528 0.449876534674742 2107 6820570
SGTC_2980 9014342 25.29 µM 0.1248696945069 0.459198936418205 no 1529 0.450313355414799 2085 2996599
SGTC_378 3970-0959 8.33 µM 0.12444329309618 0.459337540807508 no 1530 0.450482148399236 2108 6615653
SGTC_986 1493-0483 84 µM 0.124409912082966 0.459348391719068 no 1531 0.450495362807226 2178 40079
SGTC_119 0121-0043 24.815 µM 0.124133354676953 0.459438291291347 no 1532 0.450604844589154 2186 1092378
SGTC_2959 9079155 11 µM 0.120418572648343 0.460646042012197 no 1533 0.452075789804649 2107 16189457
SGTC_2425 5628681 7.85 µM 0.119590301461255 0.460915379618464 no 1534 0.452403851447932 2137 5714958
SGTC_83 0170-0301 39.027 µM 0.119494690440452 0.460946471610966 no 1535 0.452441723156442 2197 3089716
SGTC_2561 acetosyringone 100 µM 0.11915796399536 0.461055974444971 no 1536 0.452575104589462 2234 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_16 erodoxin 22.806 µM 0.118656062001691 0.461219197548569 no 1537 0.452773923991749 2163 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2274 7947094 46.08 µM 0.118418523068589 0.461296449654329 no 1538 0.452868024877414 2225 2971028
SGTC_2481 5478948 45.16 µM 0.117547653400545 0.461579685236061 no 1539 0.453213041901809 2073 77792
SGTC_1698 5-fluorocytosine 1.055 µM 0.116168824819502 0.462028165630612 no 1540 0.453759371813967 2201 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2241 6772625 37.8075 µM 0.113016396367547 0.463053710955979 no 1541 0.455008778038276 2239 2285411
SGTC_3161 9100388 49.47 µM 0.112863147769234 0.463103571973834 no 1542 0.455069526708832 2138 25236368
SGTC_2966 9084041 48.03 µM 0.11249636520634 0.463222910829959 no 1543 0.455214925797642 2063 17741380
SGTC_1417 3966-0327 90.4 µM 0.111999505938179 0.463384577599543 no 1544 0.455411899155533 2124 651118
SGTC_810 3825-7150 143 µM 0.111784330335291 0.463454592752651 no 1545 0.455497206113064 2214 22330411 YGL099W LSG1
SGTC_1667 st014849 34.6 µM 0.111376927348586 0.463587159125873 no 1546 0.45565872776098 2197 5348460
SGTC_1926 methyl fluorone black 53.6 µM 0.109913014980893 0.464063540278886 no 1547 0.456239180311242 2193 72721 Reacts with homocysteine.
SGTC_1153 4055-0057 267 µM 0.107911930914336 0.464714809155629 no 1548 0.457032776445268 2068 882706
SGTC_2251 lansoprazole 556 µM 0.107589482572629 0.464819761447413 no 1549 0.45716067012578 2015 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_567 1080-0542 68.4 µM 0.107127858165602 0.464970017802571 no 1550 0.457343773358059 2217 5950415
SGTC_775 4577-0580 57.3 µM 0.10621221880439 0.465268068434605 no 1551 0.457706988290847 2171 2006902
SGTC_1884 5633444 25 µM 0.105728680507543 0.46542547331437 no 1552 0.457898812065147 2142 5724239
SGTC_646 4092-0839 27.3 µM 0.105624942199472 0.465459243663504 no 1553 0.457939967217633 2184 877796
SGTC_1344 1488-0097 29.1 µM 0.104554414769193 0.4658077512529 no 1554 0.458364694056757 2155 747966
SGTC_2322 7413319 38.22 µM 0.103898531901346 0.466021285290141 no 1555 0.458624936088178 2133 1840400
SGTC_1993 st073995 70.8 µM 0.103069841115002 0.466291093921231 no 1556 0.458953770408951 2146 3098394
SGTC_1922 5578187 25 µM 0.102063835443172 0.466618654286654 no 1557 0.459353003101225 2221 1350412
SGTC_872 0588-0139 234 µM 0.10125866661088 0.466880837496634 no 1558 0.459672563379387 2237 2047100
SGTC_1631 benzylvanillin 81.9 µM 0.100117516385231 0.4672524492839 no 1559 0.460125514568687 2138 75506
SGTC_1742 st038235 28.8875 µM 0.0980443421316004 0.467927644416745 no 1560 0.460948541515051 2140 564103 YBR002C RER2
SGTC_2417 cerulenin 830 nM 0.0939918903029166 0.469247718948285 no 1561 0.46255779940894 2272 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2788 5282734 71.43 µM 0.093803621853464 0.469309055185511 no 1562 0.462632577275379 2207 743706
SGTC_2588 indole-3-carbinol 100 µM 0.0937233499802165 0.469335207291123 no 1563 0.462664460658207 2236 3712 Induces cell cycle arrest.
SGTC_1911 st060208 74.3 µM 0.0923524034418019 0.469781873965737 no 1564 0.463209027149934 2208 688783
SGTC_2985 9022375 71.43 µM 0.0899268680148844 0.470572227965142 no 1565 0.464172665029758 2153 4939335
SGTC_1421 4029-0249 71.4 µM 0.0868120820750781 0.471587341939485 no 1566 0.465410441888113 2266 2894095
SGTC_539 4859-0462 2.54 µM 0.0865098744435691 0.47168584184502 no 1567 0.465530553415149 2276 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1180 1193-0155 285 µM 0.0865085964250424 0.471686258399083 no 1568 0.465531061366499 2162 2921347
SGTC_233 rapamycin 362 pM 0.0861545412444215 0.47180165942293 no 1569 0.46567178355749 2253 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_29 0299-0004 12.984 µM 0.0845070051650714 0.472338689612873 no 1570 0.466326666725112 2238 16871 A napthoquinone isolated from Swertia calycina.
SGTC_879 0831-1030 162 µM 0.0843476702386859 0.472390629043176 no 1571 0.46639000602071 2246 1549252
SGTC_1096 rimcazole 32.2 µM 0.0839442390605094 0.47252214019521 no 1572 0.466550382989695 2146 18528119 A dopamine reuptake inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0815182197153419 0.473313040594472 no 1573 0.467514917930604 2202 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3102 9121669 49.47 µM 0.0814731878449899 0.473327722324289 no 1574 0.467532823488488 2150 41905072
SGTC_913 3487-1245 167 µM 0.0788798676376586 0.474173282376266 no 1575 0.468564088317947 2211 4016153
SGTC_1062 mesoridazine 14.2 µM 0.0757162549153293 0.475204945244227 no 1576 0.469822421782429 2275 4078 A neuroleptic.
SGTC_2149 5554786 194.827 µM 0.0737614283358329 0.475842503154795 no 1577 0.470600109555434 2197 745063 YPR165W RHO1
SGTC_1256 0570-0116 285 µM 0.0731954602551665 0.476027102721502 no 1578 0.470825289445611 2205 410638
SGTC_2411 st077133 39.94 µM 0.0715086624004763 0.476577309260583 no 1579 0.471496465305243 2268 1403142 YNL221C POP1
SGTC_1476 4112-3294 3.34 µM 0.0703278084699567 0.476962511603433 no 1580 0.471966374670673 2233 704369
SGTC_1437 4092-1038 11.6 µM 0.0687796858197002 0.477467551980491 no 1581 0.472582494078108 2271 3977136
SGTC_551 k048-0028 34.9 µM 0.0687717936337368 0.477470126722989 no 1582 0.472585635167146 2275 6836383
SGTC_546 peri-Naphthalide 147 µM 0.0674737623453334 0.477893608468841 no 1583 0.47310227451387 2244 223824 A penicillin ester.
SGTC_816 0325-0417 81.3 µM 0.0672152692939997 0.477977944630963 no 1584 0.473205164738026 2199 68101
SGTC_339 3091-4833 71.4 µM 0.0670085009828706 0.478045405745582 no 1585 0.473287467803863 2221 3240077
SGTC_1354 1498-1681 81 µM 0.0654465201728864 0.478555044482579 no 1586 0.473909242852253 2201 5754243
SGTC_2936 9038235 15.59 µM 0.0647256127905312 0.478790272007728 no 1587 0.474196234759908 2293 4749415
SGTC_2723 salbutamol 83.58 µM 0.0645164152609585 0.478858533226828 no 1588 0.474279518426485 2284 9884233 β2-adrenoceptor agonist
SGTC_823 0417-1665 178 µM 0.0636396527079771 0.479144627843804 no 1589 0.474628578711677 2212 3429856
SGTC_741 4582-0002 126 µM 0.0627717422403514 0.479427844538467 no 1590 0.474974133952447 2256 2912688
SGTC_3180 9109287 49.47 µM 0.0625789936844 0.479490743695292 no 1591 0.475050878618393 2250 18891271
SGTC_3220 9131269 49.47 µM 0.0623349341014377 0.479570387784495 no 1592 0.475148054584256 2310 17722206
SGTC_2618 avocadyne 43.43 µM 0.0619120805847513 0.479708379719042 no 1593 0.475316423519899 2232 3015189
SGTC_1831 st055328 12 µM 0.0619035501541387 0.479711163522846 no 1594 0.475319820154167 2293 1103068
SGTC_2790 5423970 71.43 µM 0.061430814129003 0.479865436802701 no 1595 0.475508056283754 2276 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_796 1234-0020 70.7 µM 0.0611795150743905 0.479947447287293 no 1596 0.475608121885176 2315 46495034
SGTC_693 4161-2696 114 µM 0.0608389556265406 0.480058588913547 no 1597 0.475743732831697 2271 805759
SGTC_891 0929-0073 133 µM 0.0604004186329043 0.480201707808664 no 1598 0.475918362623526 2279 5603632
SGTC_627 1391-0720 175 µM 0.0583434528494177 0.480873043361109 no 1599 0.476737528036641 2248 997839
SGTC_1213 1315-0166 115 µM 0.057234655639716 0.481234946087823 no 1600 0.477179136093844 2115 768401
SGTC_308 4092-1169 104 µM 0.0567282147394461 0.481400249595106 no 1601 0.477380849044106 2270 2268590 YDL196W YDL196W
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0567270108256821 0.481400642559227 no 1602 0.477381328564034 2261 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_949 1165-0505 146 µM 0.0558356318253266 0.481691598536451 no 1603 0.477736374558307 2242 6244267
SGTC_771 0250-0039 27.3 µM 0.0554376515025756 0.481821506879549 no 1604 0.477894900191841 2181 3005115
SGTC_2881 9058953 51.95 µM 0.0546873431616256 0.482066427024594 no 1605 0.478193776483472 2297 17122249
SGTC_3302 9125395 16.351 µM 0.0544368881666128 0.4821481835563 no 1606 0.478293544952891 2226 17599668
SGTC_861 0443-0273 110 µM 0.0512857292855328 0.48317688574889 no 1607 0.479548919760107 2241 6149169
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.051232786218819 0.483194170095985 no 1608 0.479570013257956 2224 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1048 3161-0300 24.5 µM 0.0506252785626854 0.483392505649477 no 1609 0.479812059634428 2310 2165101
SGTC_1564 D-Arginine 115 µM 0.0505017380587463 0.483432838936504 no 1610 0.479861282201635 2250 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_757 1066-0008 322 µM 0.0498853402761974 0.483634081928323 no 1611 0.480106879761626 2293 6842497
SGTC_2516 gossypol 71.55 µM 0.0495431511323571 0.483745802444498 no 1612 0.480243224885274 2309 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1909 st060837 51.5 µM 0.0489864083444606 0.483927574790691 no 1613 0.480465063752886 2257 678937
SGTC_1799 st045822 46.1415 µM 0.047943384420449 0.484268123243442 no 1614 0.480880681678801 2321 3674992
SGTC_2419 paclitaxel 166.5 µM 0.0473234753177479 0.48447052969695 no 1615 0.481127709221112 2237 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3210 9128157 49.47 µM 0.0469915248677999 0.484578916450575 no 1616 0.481259991121967 2127 17590849
SGTC_376 3970-0862 59.1 µM 0.0464328686056246 0.484761328588301 no 1617 0.481482619698679 2319 3135186
SGTC_1471 k673-0312 37 µM 0.0461728321197519 0.484846236649697 no 1618 0.481586248100226 2331 24099884
SGTC_1194 1488-0194 225 µM 0.045276549335223 0.485138899413639 no 1619 0.481943439592407 2295 1391452
SGTC_1785 bathophenanthroline 24 µM 0.044995241087204 0.485230756511476 no 1620 0.482055551088297 2250 72812 An iron chelator.
SGTC_1259 0671-0132 43 µM 0.0448561918861862 0.485276161285985 no 1621 0.482110967741097 2274 X1259
SGTC_2744 captopril 92.04 µM 0.0437602331392414 0.485634039518672 no 1622 0.482547763028364 2321 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2796 7949634 45.45 µM 0.043582103952264 0.4856922075521 no 1623 0.482618758559732 2310 2971588
SGTC_1842 st055362 61.2 µM 0.043542440186886 0.485705159784461 no 1624 0.482634567105908 2262 676032
SGTC_1339 1486-1321 22.7 µM 0.0429020136194723 0.485914293638861 no 1625 0.482889821796977 2277 3469382
SGTC_748 act1.228 77.9 µM 0.0417919322698636 0.486276804283146 no 1626 0.48333228325584 2312 4421505 YNR035C ARC35
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0414181747276986 0.486398861947529 no 1627 0.483481261945746 2318 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3145 9085516 49.47 µM 0.0414094195099359 0.486401721146437 no 1628 0.483484751778292 2200 25236195
SGTC_1746 st038117 42 µM 0.0396620280216983 0.486972382067577 no 1629 0.484181287545084 2285 2898218
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0393867232167311 0.48706229322804 no 1630 0.484291032517455 2286 5282362
SGTC_502 l-744,832 89.3 µM 0.0391440712951746 0.487141540904114 no 1631 0.484387762031998 2348 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1232 0279-0259 161 µM 0.0384151637322141 0.487379597820962 no 1632 0.484678335498052 2315 1560000
SGTC_2897 9048598 12.99 µM 0.037397345361874 0.487712018810822 no 1633 0.485084094643066 2323 6467404
SGTC_2933 9026794 32.47 µM 0.037397167466049 0.487712076912615 no 1634 0.485084165563621 2312 17586027
SGTC_732 3970-1727 52.7 µM 0.0351988521529856 0.488430078786483 no 1635 0.485960588757356 2334 1275699
SGTC_3208 9114115 49.47 µM 0.0344823575871812 0.488664104587424 no 1636 0.486246255293903 2253 650895
SGTC_1768 st044301 37.178 µM 0.0338154898468079 0.488881924482211 no 1637 0.486512141949116 2344 3931349
SGTC_2366 9070441 60.58 µM 0.0330324578820459 0.489137691479874 no 1638 0.48682435205544 2352 6837235
SGTC_1100 amiodarone 5.07 µM 0.0316009608950165 0.48960528244231 no 1639 0.48739513854523 2361 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_73 0327-0325 16.231 µM 0.0307663952572418 0.489877895552627 no 1640 0.487727920212844 2354 53298
SGTC_1243 0416-0003 5.65 µM 0.0292778178761638 0.490364155014531 no 1641 0.488321509043953 2325 2141977
SGTC_320 4092-0846 5.34 µM 0.0267975878932866 0.491174379685243 no 1642 0.48931058855539 2348 1359356
SGTC_468 gf-109203x 121 µM 0.0264870935185881 0.491275812510337 no 1643 0.489434413934473 2361 2396 A protein kinase C inhibitor.
SGTC_367 0335-0881 7.1 µM 0.0244828408170089 0.491930578444896 no 1644 0.490233735328798 2345 23828853
SGTC_1431 4049-0260 9.09 µM 0.0238062263338406 0.492151625486288 no 1645 0.490503586780956 2355 3854841
SGTC_2805 7950783 58.44 µM 0.0235500533040972 0.492235316745919 no 1646 0.49060575638841 2339 1178958 YDL195W SEC31
SGTC_1268 0828-0275 2.46 µM 0.0233387577383636 0.492304346877644 no 1647 0.490690027960383 2349 745337
SGTC_1707 st032323 6.317 µM 0.0230925460066771 0.492384784389967 no 1648 0.490788225763607 2364 3132057 YMR211W DML1
SGTC_439 amiodarone 34.4 µM 0.0223387533896989 0.492631050776575 no 1649 0.491088867926262 2302 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_724 3910-0327 137 µM 0.0223259461303568 0.492635234972468 no 1650 0.491093976009564 2341 2885483
SGTC_283 0987-0079 11.7 µM 0.0222664950657304 0.492654657944206 no 1651 0.491117687658337 2346 411556
SGTC_1700 st030840 7.9285 µM 0.0211921704979389 0.493005648318641 no 1652 0.491546179959461 2362 5499307
SGTC_278 4092-0821 23.9 µM 0.0206961995261091 0.493167687820339 no 1653 0.491744000355353 2349 877900
SGTC_2048 5246248 200 µM 0.0205272999821765 0.493222869530129 no 1654 0.491811367212758 2376 677046
SGTC_602 3130-1533 38.1 µM 0.0200536716084864 0.493377610858139 no 1655 0.492000278702662 2371 720941
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0193768154463129 0.493598751405676 no 1656 0.492270252765031 2273 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2540 epiandrosterone 100 µM 0.0187583972519126 0.493800800985751 no 1657 0.492516921080696 2375 441302 A steroid.
SGTC_2383 9036125 200 µM 0.0174392712937322 0.494231791041275 no 1658 0.493043089975394 2352 79580
SGTC_2849 9019321 12.99 µM 0.0164501034243072 0.49455498032879 no 1659 0.493437654196654 2355 16489627
SGTC_1568 digitonin 820 nM 0.013237041137037 0.495604802761118 no 1660 0.494719338835728 2380 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1120 ficusin 1.78878 µM 0.0130472905766485 0.495666802082844 no 1661 0.494795031819887 2351 6199 A DNA cross-linker.
SGTC_639 0833-0042 114 µM 0.0119707926834639 0.496018540210201 no 1662 0.495224458724665 2369 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2223 6903751 107.57 µM 0.0099840562204478 0.496667700323646 no 1663 0.496017004015623 2381 5598863
SGTC_526 4469-0568 170 µM 0.00994976697792991 0.49667890431204 no 1664 0.49603068276479 2384 2901964
SGTC_401 neomycin 50 µM 0.00988920142592607 0.496698694074402 no 1665 0.496054843735514 2334 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2458 5808907 16.39 µM 0.00860028512192768 0.497119848648977 no 1666 0.496569024936698 2390 2731747
SGTC_150 3970-0969 77.2 µM 0.00727667772154517 0.497552341907157 no 1667 0.497097051214585 2369 6615640
SGTC_2221 6807166 181.081 µM 0.00710997273567105 0.497606813547584 no 1668 0.497163555161117 2397 674925
SGTC_316 k060-0003 58.6 µM 0.00692130704065438 0.497668461007071 no 1669 0.497238820031347 2390 6152314
SGTC_1060 3448-7350 82 µM 0.00599367072008302 0.497971571596435 no 1670 0.497608885651397 2389 570178
SGTC_231 b-estradiol 524 µM 0.00542792174723366 0.49815643396589 no 1671 0.497834583153363 2396 450 A steroid.
SGTC_1130 3454-2858 15.9 µM 0.00483403492993675 0.498350490994794 no 1672 0.498071506592319 2381 715628 YIL048W NEO1
SGTC_968 1309-0633 340 µM 0.00445136370866299 0.498475531932889 no 1673 0.498224168675748 2398 3761976
SGTC_1773 st048542 73.5835 µM 0.00294856753691317 0.49896658415402 no 1674 0.498823693447385 2391 3237138
SGTC_1238 0333-0287 48.8 µM 0.00200577357341169 0.499274651442556 no 1675 0.499199812653197 2398 7226
SGTC_105 0111-0055 734.78 µM 0.00143727852788666 0.499460413064034 no 1676 0.499426609023928 2386 5179370
SGTC_1658 st012944 20 µM 0.000473806755579468 0.499775237651948 no 1677 0.499810978459532 2404 24207260
SGTC_2572 astragaloside iv 100 µM -1.1913043565921e-05 0.49993395179695 no 1678 0.499995247383233 2406 45006101 An anti-inflammatory agent.
SGTC_1124 fisetin 1.16336 µM -0.00041617339128328 0.49993395179695 no 1679 0.499833970843032 2408 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_928 2764-0428 58.7 µM -0.00108206866178374 0.499716363395239 no 1680 0.499568317144758 2417 662578
SGTC_2711 st079103 59.1 µM -0.00147622442914687 0.499587568818168 no 1681 0.499411071873754 2411 54693780
SGTC_2644 guaiazulene 100 µM -0.00177185672299157 0.499490967858405 no 1682 0.499293131808251 2404 3515 A coloring agent.
SGTC_598 3937-0236 20.2 µM -0.00203025624070159 0.499406533123892 no 1683 0.499190045501966 2411 1379313
SGTC_1604 st002052 72.4 µM -0.00232581414561821 0.499309956532045 no 1684 0.499072135237491 2429 6254834 YHR062C RPP1
SGTC_941 3237-0776 460 µM -0.00297896967068934 0.499096531383457 no 1685 0.498811564804076 2413 760008
SGTC_2367 9070478 135.38 µM -0.00330249120084069 0.498990817555841 no 1686 0.498682499024207 2418 572802
SGTC_2319 6033012 152.6 µM -0.00340656722594528 0.498956809710324 no 1687 0.498640978931046 2416 847246
SGTC_1401 3807-4679 7.6 µM -0.00360990677767121 0.498890366571711 no 1688 0.498559858685929 2407 3291456
SGTC_1901 st060216 58.6 µM -0.00363860007125348 0.498880990766703 no 1689 0.498548411793135 2406 688792
SGTC_140 0062-0056 502.533 µM -0.00504182485068568 0.498422474655907 no 1690 0.497988611418269 2419 3758964
SGTC_202 3594-0513 34.79 µM -0.00522594782272558 0.498362310987523 no 1691 0.497915157948038 2410 708429
SGTC_882 0843-0131 351 µM -0.00810415202703167 0.497421840224194 no 1692 0.496766946499348 2413 5425421
SGTC_392 N-ethylmaleimide 8.33 µM -0.00855947692248758 0.497273061218151 no 1693 0.496585304453627 2427 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1708 st033234 31.827 µM -0.00909240636053389 0.497098925138959 no 1694 0.496372704651466 2433 674664
SGTC_2329 6138490 200 µM -0.00988360834380882 0.496840398863619 no 1695 0.496057074943406 2471 720019
SGTC_3093 9117344 49.47 µM -0.0100610865242442 0.496782407816072 no 1696 0.495986274914012 2498 24824913
SGTC_2628 lathosterol 100 µM -0.0121947237994871 0.49608524688453 no 1697 0.495135129655722 2450 6710616
SGTC_2087 5276107 200 µM -0.0128639582704542 0.495866578467288 no 1698 0.494868164690221 2430 144405
SGTC_1945 st075991 56.6 µM -0.0156866900911852 0.494944281930582 no 1699 0.493742172730393 2451 1084980
SGTC_1216 1165-0504 9.65 µM -0.0160092892206275 0.494838877845713 no 1700 0.493613490459451 2436 6304004
SGTC_3001 9076041 71.4286 µM -0.0161611657179174 0.494789254763533 no 1701 0.493552908341192 2438 16004211
SGTC_1791 st048313 56.1 µM -0.0168048338618944 0.494578947965234 no 1702 0.493296156789135 2439 1204976
SGTC_2941 9056145 11.23 µM -0.0180157532061683 0.4941833063379 no 1703 0.49281314310475 2432 2119517
SGTC_2065 5221596 34.26 µM -0.0182388114846688 0.494110427496695 no 1704 0.492724170346 2454 788581
SGTC_1646 st011709 75.6 µM -0.0201500376196521 0.493485989374805 no 1705 0.491961841993054 2435 5757843
SGTC_1004 4084-0029 199 µM -0.0224689792139666 0.492728363541577 no 1706 0.491036928375727 2460 716894 YLR208W SEC13
SGTC_67 0335-0847 266 µM -0.0225160609786316 0.492712981630846 no 1707 0.49101815021983 2479 4552207 YOR254C SEC63
SGTC_512 prima-1 270 µM -0.0234987858630332 0.492391921694551 no 1708 0.49062620347978 2473 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_250 brefeldin a 552.239 µM -0.0237288239528676 0.492316768084836 no 1709 0.49053445714283 2434 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1822 st052468 42 µM -0.0239404824990181 0.492247619326137 no 1710 0.490450041581173 2453 2873678
SGTC_649 1123-0311 367 µM -0.0247814529166056 0.491972876963689 no 1711 0.490114642472111 2465 693629 YIL048W NEO1
SGTC_922 1866-0035 480 µM -0.0260703852415999 0.491551794305773 no 1712 0.489600599092227 2463 3156169
SGTC_2129 girgensonine 121.053 µM -0.0262675891173155 0.491487370382759 no 1713 0.489521953062109 2485 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0274656518287081 0.491095983821987 no 1714 0.489044167688043 2480 6708760
SGTC_680 0417-1641 114 µM -0.0280088550064383 0.490918531452754 no 1715 0.488827544322449 2456 2835990
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0288141015928544 0.490655478660843 no 1716 0.488506427052682 2467 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2144 5628481 200 µM -0.0288776611303244 0.490634715610224 no 1717 0.488481081013089 2443 2818399
SGTC_2733 amorolfine 100 µM -0.0347337596271868 0.488721814919155 no 1718 0.486146020435539 2480 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_930 2810-3379 265 µM -0.0350321582535071 0.488624349269476 no 1719 0.486027049013004 2463 1015764
SGTC_1596 piperlongumine 63 µM -0.0350950562425332 0.488603805047709 no 1720 0.486001971766265 2464 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_352 k048-0007 5.11 µM -0.0352577921405908 0.488550651145712 no 1721 0.485937089690401 2467 6811911
SGTC_485 niflumic acid 177 µM -0.0356030269054128 0.488437888901425 no 1722 0.485799447366013 2531 4488 A COX2 inhibitor.
SGTC_863 0466-0191 129 µM -0.0356532593909251 0.488421481801496 no 1723 0.485779420218605 2469 765160 YPR165W RHO1
SGTC_276 colchicine 750 µM -0.0366938130545099 0.488081617183413 no 1724 0.485364570894985 2539 2833 A microtubule depolymerizer.
SGTC_2004 4023728 41.89 µM -0.037816625408302 0.487714895027932 no 1725 0.484916944347349 2479 360084 YDR527W RBA50
SGTC_3025 9087895 49.47 µM -0.0403723074934103 0.486880221982649 no 1726 0.483898153831091 2485 17173641
SGTC_52 0329-0193 875 nM -0.0431644246196305 0.485968396247072 no 1727 0.482785231842189 2622 3739292
SGTC_3050 9093513 49.47 µM -0.0436733134932298 0.485802215433654 no 1728 0.482582405830419 2493 25236664
SGTC_1711 st032263 62.8 µM -0.0452561612940241 0.485285342572112 no 1729 0.481951564915222 2521 3958979
SGTC_2782 7736369 71.43 µM -0.0454042818751894 0.48523697561754 no 1730 0.481892534033202 2498 2950836 YOL077C BRX1
SGTC_2187 6125751 200 µM -0.0456754887785617 0.485148416901275 no 1731 0.481784450267612 2514 874498
SGTC_127 0180-0333 59.125 µM -0.046180514386952 0.484983510002912 no 1732 0.481583186584783 2477 771601
SGTC_2837 9008476 45.46 µM -0.0463325977335723 0.484933850462651 no 1733 0.481522578982529 2554 2992805
SGTC_2836 9010338 19.48 µM -0.0465003813201064 0.484879064618429 no 1734 0.481455715083609 2509 2994051
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.046805161111699 0.484779546567246 no 1735 0.4813342577857 2494 803109
SGTC_254 nsc-64875 3.808 µM -0.0474566693012521 0.484566816406821 no 1736 0.481074632143865 2543 56993
SGTC_475 α-linolenic acid 10 µM -0.0476275960045119 0.484511006221622 no 1737 0.481006519274886 2565 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_315 k915-0449 187 µM -0.0487210066171161 0.484153998143863 no 1738 0.480570817447212 2516 20970215 YNL149C PGA2
SGTC_3235 9132602 49.47 µM -0.049875766916871 0.483776972657137 no 1739 0.480110694231141 2563 4912240
SGTC_2172 5754775 163.918 µM -0.0504139646945878 0.483601257766058 no 1740 0.479896254160119 2510 2263357
SGTC_3014 9081533 49.47 µM -0.0504287888156254 0.483596417919539 no 1741 0.479890347704278 2506 21367265
SGTC_714 4296-0578 26.1 µM -0.0506786409900172 0.48351484540849 no 1742 0.479790798397623 2540 1589775
SGTC_868 0527-0199 213 µM -0.0517325778175343 0.483170760486076 no 1743 0.479370889320508 2557 2849450
SGTC_1053 3366-3204 134 µM -0.0519887675538613 0.483087122607808 no 1744 0.479268821752353 2526 3632071 YPR165W RHO1
SGTC_1727 st034309 9.9045 µM -0.0527888137940707 0.482825937521845 no 1745 0.478950087186718 2612 870305
SGTC_2373 9071805 200 µM -0.052987888394129 0.482760948273402 no 1746 0.478870778909205 2505 10149009
SGTC_651 3253-0966 34.4 µM -0.0531273095942785 0.482715433553098 no 1747 0.478815236132253 2514 781462
SGTC_2263 7948595 193.29 µM -0.0532113639911728 0.482687993700396 no 1748 0.47878175064433 2492 2971371
SGTC_2333 9017922 200 µM -0.0534147288152513 0.482621604879705 no 1749 0.47870073503421 2545 3163164
SGTC_1563 conessine 56.1 µM -0.0539151751885478 0.482458235296831 no 1750 0.478501373099609 2524 441082 An anti-amoebic, histamine inhibitor.
SGTC_295 k015-0027 31 µM -0.0539560132318493 0.482444903939886 no 1751 0.478485104757403 2555 3887424
SGTC_1175 0741-0056 27.6 µM -0.0547981159711931 0.4821700084816 no 1752 0.478149650693143 2539 765927
SGTC_2521 angolensin 13.4 µM -0.0557333509489255 0.481864720937847 no 1753 0.477777115284294 2577 821428 A flavenoid.
SGTC_2205 7238770 200 µM -0.055779017426728 0.481849814359437 no 1754 0.477758925291578 2554 279867
SGTC_959 1222-0044 107 µM -0.055904579115188 0.481808828295519 no 1755 0.477708911465326 2517 6083612
SGTC_2124 5246320 200 µM -0.0592597052100483 0.48071371480581 no 1756 0.476372627633336 2581 579342
SGTC_727 3032-0951 202 µM -0.0602482649054823 0.480391076210813 no 1757 0.475978952833419 2555 3652836
SGTC_2576 guaiol 23.12 µM -0.0612469481528978 0.48006514661208 no 1758 0.475581270333407 2611 227829
SGTC_698 k064-0052 127 µM -0.0613984253815986 0.480015711763385 no 1759 0.475520953179585 2496 5088751
SGTC_1723 st034307 2.5525 µM -0.0615499172667511 0.479966272438946 no 1760 0.475460630750725 2561 867466
SGTC_1642 st009582 77.7 µM -0.0639910240830361 0.479169661093312 no 1761 0.474488686952381 2538 6739311
SGTC_1943 st076331 65.2 µM -0.0652817148717782 0.478748500769115 no 1762 0.473974850352052 2521 24208415
SGTC_2822 7994718 71.43 µM -0.0655766476122302 0.478652265719734 no 1763 0.473857440795445 2514 1018011
SGTC_560 2332-1943 155 µM -0.066187269051292 0.478453027019794 no 1764 0.473614366187144 2507 21177716
SGTC_362 0310-0100 9.03 µM -0.0662832508199003 0.478421709769333 no 1765 0.473576158903273 2581 790235
SGTC_3115 9123671 49.47 µM -0.0663679808144504 0.478394063895821 no 1766 0.473542430794135 2519 3286988
SGTC_963 1269-2853 151 µM -0.0671535419520399 0.478137754390856 no 1767 0.473229734870318 2557 3668223
SGTC_1861 st057647 17.4 µM -0.0671623532766474 0.47813487952089 no 1768 0.473226227578586 2635 688668
SGTC_1947 st076332 61.6 µM -0.0689971085725528 0.47753627910881 no 1769 0.472495960520551 2516 24208416
SGTC_1548 st061468 90.8 µM -0.0706483154147405 0.476997605818182 no 1770 0.471838828155389 2547 390799
SGTC_686 1319-0111 510 µM -0.0726406375183229 0.476347706516512 no 1771 0.471046044029153 2565 4562600
SGTC_2807 7945238 51.95 µM -0.074375045836731 0.475781990348494 no 1772 0.470355982167528 2594 17148797
SGTC_2536 dehydroabietamide 32.04 µM -0.0750043857930042 0.475576729018568 no 1773 0.470105611183186 2591 3983547
SGTC_1684 st024538 14.6195 µM -0.0751451845621159 0.475530807914796 no 1774 0.470049598673342 2542 6732859
SGTC_237 nikkomycin 200 µM -0.0760021669970782 0.475251312650002 no 1775 0.469708687086152 2555 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_873 0591-4978 488 µM -0.0777349118293688 0.474686234592087 no 1776 0.469019461247543 2616 3305145
SGTC_507 nimesulide 162 µM -0.0785531213236487 0.474419419954654 no 1777 0.468694038009928 2651 4495 A COX2 inhibitor.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0786330233838537 0.474393364845515 no 1778 0.468662259995889 2718 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1636 st007707 68.9 µM -0.0797890858248042 0.474016398979491 no 1779 0.468202502449111 2593 403051
SGTC_2385 9074692 200 µM -0.0798177853236241 0.47400704101531 no 1780 0.468191089406017 2565 17046906
SGTC_1784 st039334 36.3 µM -0.0806852457218345 0.473724197455638 no 1781 0.467846135382469 2750 3496984
SGTC_2378 9074213 121.43 µM -0.0817145736587681 0.473388592668975 no 1782 0.467436844507047 2557 657714
SGTC_900 1112-0045 141 µM -0.0835424959637849 0.472792658778379 no 1783 0.466710094288958 2582 56211 YIL048W NEO1
SGTC_833 3852-0053 558 µM -0.0855316189026901 0.472144239957061 no 1784 0.465919379658226 2651 3123681
SGTC_2584 androsterone 48.74 µM -0.0872362931177298 0.471588605052674 no 1785 0.465241845785649 2572 2754130 A steroid.
SGTC_3015 9080845 49.47 µM -0.0875763864667166 0.471477758936758 no 1786 0.465106685461019 2642 5296973
SGTC_673 1082-0474 110 µM -0.0883052297626157 0.471240215584929 no 1787 0.464817041223342 2569 3098046
SGTC_2831 7999036 19.48 µM -0.0894443489069055 0.470868976358522 no 1788 0.464364389679163 2770 2988270
SGTC_1091 telmisartan 47.6 µM -0.0911572422280937 0.470310791730878 no 1789 0.46368382460189 2666 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1467 k284-1082 293 µM -0.0923022695632312 0.469937691406749 no 1790 0.463228942609579 2586 3334705
SGTC_1810 st050138 53 µM -0.0926045643171264 0.46983919485536 no 1791 0.463108858766212 2561 3444541
SGTC_818 4072-2707 53.5 µM -0.0932576069884784 0.469626420589715 no 1792 0.462849454989909 2577 882871
SGTC_2138 5575593 77.673 µM -0.0933088016849902 0.469609740707172 no 1793 0.462829119929063 2569 762213
SGTC_3164 9100705 49.47 µM -0.0934892082635027 0.469550962377158 no 1794 0.462757461352236 2693 17174235
SGTC_1237 0330-0133 46.1 µM -0.0955700877452171 0.468873038600977 no 1795 0.461931011474117 2587 X1237 YHR072W ERG7
SGTC_735 3076-0345 636 µM -0.0959695137645743 0.468742921002924 no 1796 0.461772392633124 2642 2888990
SGTC_726 3448-4391 34.2 µM -0.0972512778313776 0.468325394301756 no 1797 0.461263423587817 2694 1356692
SGTC_3257 9139206 32.98 µM -0.0974195878399694 0.468270570937358 no 1798 0.461196594933823 2624 4910041
SGTC_3337 9144342 33.5465 µM -0.0979327189792237 0.468103433225981 no 1799 0.460992859433601 2677 17682949
SGTC_139 0099-0334 718.624 µM -0.0982492869168175 0.468000323126907 no 1800 0.460867173222647 2578 97690
SGTC_738 1315-0003 72.4 µM -0.100646142849537 0.467219707605303 no 1801 0.459915682976877 2662 6251474
SGTC_1782 st039423 80.636 µM -0.103321885020641 0.46634841258757 no 1802 0.45885375341889 2629 2068169
SGTC_1464 k208-0027 110 µM -0.103324190457723 0.466347661942973 no 1803 0.458852838578876 2615 X1464
SGTC_2151 5563267 85.4165 µM -0.103942147249086 0.466146461069084 no 1804 0.458607629783817 2637 5310824
SGTC_867 0518-0118 155 µM -0.105428025036023 0.465662708856814 no 1805 0.458018089607361 2614 6848158
SGTC_1626 st003712 1.76 µM -0.105821216267988 0.465534707375137 no 1806 0.457862101578064 2701 24207035
SGTC_3241 9133421 49.47 µM -0.106619375077117 0.465274881659849 no 1807 0.457545473556432 2574 17018221
SGTC_3328 9140624 29.0385 µM -0.106660115090635 0.465261619904367 no 1808 0.457529312794654 2660 4904392
SGTC_2346 9031566 143.75 µM -0.107228211790665 0.465076696169052 no 1809 0.45730396734035 2699 4771086
SGTC_25 0118-0223 35.662 µM -0.107569481160829 0.46496561165104 no 1810 0.457168603493729 2628 5333628
SGTC_3207 9114163 49.47 µM -0.107959986847682 0.464838503868985 no 1811 0.457013716252887 2714 849233
SGTC_2001 4023502 57.655 µM -0.108385492627424 0.46470000780478 no 1812 0.45684495427288 2692 108941 YCR052W RSC6
SGTC_2717 st081029 62.2815 µM -0.108567150858154 0.464640881942484 no 1813 0.45677290826035 2604 5292846
SGTC_3085 9117376 49.47 µM -0.109894056313914 0.464209026406323 no 1814 0.456246698184305 2682 16480349
SGTC_2655 perillic acid 100 µM -0.110803264646981 0.463913139166997 no 1815 0.455886178240958 2603 5702197 An apoptosis inducer.
SGTC_535 2293-4129 48.2 µM -0.111233093816929 0.463773265109826 no 1816 0.45571575469392 2604 396118 YIL048W NEO1
SGTC_1678 st019265 80.2 µM -0.11154564213415 0.46367155913899 no 1817 0.455591837104964 2643 5367020
SGTC_836 0330-0104 1.35 µM -0.1119407688386 0.463542984833619 no 1818 0.455435185435817 2618 46494820
SGTC_331 k048-0133 24.5 µM -0.112601142046878 0.463328107771857 no 1819 0.455173389793716 2597 6813582
SGTC_1206 3978-0017 132 µM -0.113154654330901 0.463148010137957 no 1820 0.454953972648765 2884 3873677
SGTC_1329 1447-1697 50.6 µM -0.114516760293349 0.462704850657087 no 1821 0.454414080503187 2739 2840515
SGTC_1359 1582-0056 520 nM -0.115214028748895 0.46247801310916 no 1822 0.454137739696009 2709 3661189
SGTC_2759 disulfiram 3.38 µM -0.11545371332589 0.462400040989749 no 1823 0.4540427532403 2613 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_303 1348-1668 34.2 µM -0.115588489498406 0.46235619740214 no 1824 0.453989342902194 2647 5380509
SGTC_374 0880-0231 82.3 µM -0.117239201368549 0.461819247090347 no 1825 0.453335251452252 2680 6833587
SGTC_1181 1222-0449 220 µM -0.117790644601805 0.461639886835854 no 1826 0.453116771233678 2742 658318
SGTC_123 0083-0120 66.675 µM -0.117941778024442 0.461590731134505 no 1827 0.453056895082359 2612 16001701
SGTC_2955 9076254 12.21 µM -0.118798570747987 0.461312072934119 no 1828 0.452717470522063 2635 16459619
SGTC_985 1493-0307 8.71 µM -0.119214975514872 0.461176650759466 no 1829 0.452552521257656 2654 3278274
SGTC_3308 9128332 17.569 µM -0.119895209998009 0.460955436198679 no 1830 0.452283079486484 2739 17332805 YDL196W YDL196W
SGTC_201 4262-0159 12.803 µM -0.119896523199037 0.460955009152913 no 1831 0.452282559347046 2716 1341029
SGTC_3342 9147791 14.508 µM -0.120755283490811 0.460675754685688 no 1832 0.451942434719155 2618 1838168
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.121081258763118 0.460569758055744 no 1833 0.451813336645686 2750 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2504 purpurogallin 52.29 µM -0.123990183462873 0.459623994627698 no 1834 0.450661523773261 2650 5281571 An antioxidant.
SGTC_1761 st044296 37 µM -0.125868694618188 0.459013365200479 no 1835 0.449917931813577 2609 1826700
SGTC_2314 7727897 200 µM -0.126319478023027 0.458866847736163 no 1836 0.449739519263085 2654 900724
SGTC_1989 st071868 50.2 µM -0.12729562567395 0.458549591083435 no 1837 0.449353211174995 2731 16414057
SGTC_1350 1495-0454 146 µM -0.127867317333141 0.458363798464949 no 1838 0.449126987838443 2763 1069057
SGTC_2041 5107442 45.335 µM -0.12819389021616 0.458257670453683 no 1839 0.448997767539231 2688 793005
SGTC_3323 9138564 53.9225 µM -0.128834785564193 0.458049404167373 no 1840 0.448744189997085 2691 43912313 YNL103W MET4
SGTC_1738 st035555 74 µM -0.130133165059884 0.457627516234277 no 1841 0.448230535645305 2724 5331140
SGTC_1704 st028805 70.8 µM -0.130572315257883 0.457484832086545 no 1842 0.448056822207622 2672 2876101
SGTC_1967 st070177 51.4 µM -0.130847168682179 0.457395532336935 no 1843 0.447948104259308 2763 5729214
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.131866047739024 0.457064517806962 no 1844 0.447545122022682 2631 1377
SGTC_2027 5150920 200 µM -0.132028839362738 0.457011632642022 no 1845 0.447480740453287 2723 786715
SGTC_995 3931-2021 34.6 µM -0.132203352832995 0.456954940314735 no 1846 0.447411724611715 2736 730143
SGTC_1409 3909-8004 61.9 µM -0.133474599814539 0.456541990391283 no 1847 0.446909025463241 2671 2119279
SGTC_440 fluspirilene 35.1 µM -0.134756336695082 0.456125680458065 no 1848 0.446402264563003 2905 3396 An atypical antipsychotic.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.13521598427444 0.455976397989419 no 1849 0.446220554766381 2842 94937 An inhibitor of serotonin biosynthesis.
SGTC_2694 st077685 81.9 µM -0.136518420753453 0.455553431796682 no 1850 0.445705731611565 2636 2838096
SGTC_745 0469-0705 296 µM -0.136703997417679 0.45549316987148 no 1851 0.445632384858662 2758 3486736
SGTC_3287 9117173 37.0625 µM -0.137382896990452 0.455272720957336 no 1852 0.44536407454251 2647 2789709
SGTC_1868 st057644 42.7 µM -0.137481559128084 0.455240685020142 no 1853 0.445325084007682 2638 688665
SGTC_2678 equilin 100 µM -0.138087887834623 0.455043814391426 no 1854 0.445085479088749 2722 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2895 9054447 58.44 µM -0.141742907051363 0.45385729116558 no 1855 0.44364154107514 2665 2697450
SGTC_395 anisomycin 6.25 µM -0.142223575848512 0.45370128280357 no 1856 0.443451705121285 2707 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2255 7941087 197.44 µM -0.142549960786332 0.453595353683448 no 1857 0.44332280962855 2782 935561
SGTC_3086 9117350 49.47 µM -0.144804927420542 0.452863588721686 no 1858 0.442432445857446 2660 2679265
SGTC_271 rotenone 740 µM -0.144912878885507 0.45282856111176 no 1859 0.442389828946586 2797 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2591 skatole 100 µM -0.145155249665903 0.452749919059453 no 1860 0.442294148617609 2782 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1716 st033144 30.6155 µM -0.146467939720528 0.452324022769274 no 1861 0.44177599867055 2748 674617
SGTC_870 0573-2213 57.6 µM -0.147046770643787 0.452136241118169 no 1862 0.441547551950084 2650 3916321
SGTC_1795 st049545 62.3 µM -0.149395520787059 0.451374380761334 no 1863 0.440620772981592 2655 5291882
SGTC_1111 tnp00062 510.699 nM -0.149684404066397 0.45128068846092 no 1864 0.440506806647246 2793 676306
SGTC_1609 st001574 46.4 µM -0.149916738995424 0.451205338218291 no 1865 0.440415152580198 2684 3960012
SGTC_1049 3226-0134 66 µM -0.150225663820179 0.451105151269129 no 1866 0.440293289424341 2624 5702385
SGTC_1777 st045864 34.765 µM -0.150263754784757 0.451092798260794 no 1867 0.440278263878115 2676 4691462
SGTC_1821 st053465 65.6 µM -0.150649247772061 0.450967784454086 no 1868 0.440126205291777 2763 675086
SGTC_162 k030-0015 37.8 µM -0.151854769213754 0.45057687019992 no 1869 0.439650741701974 2768 1809920 YMR134W ERG29
SGTC_2563 tomatine 8.54 µM -0.154021514233522 0.449874380886574 no 1870 0.438796386044625 2652 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2213 7173844 200 µM -0.154575476349167 0.449694803671888 no 1871 0.438578002315099 2694 892728
SGTC_1351 1496-0003 46.5 µM -0.157944120807685 0.448603017472887 no 1872 0.437250415500832 2796 3891978
SGTC_2062 5245942 200 µM -0.159524113050469 0.448091071538786 no 1873 0.436627981050675 2655 1376160
SGTC_1839 st053978 48 µM -0.162172910816763 0.447233007729964 no 1874 0.435584845714662 2692 3788398
SGTC_416 estradiol valerate 100 µM -0.163949398375032 0.446657662216646 no 1875 0.43488548945655 2759 13791 A steroid.
SGTC_641 4092-0595 30 µM -0.164249083885234 0.446560615034043 no 1876 0.434767531199488 2742 786260
SGTC_2460 5552655 174.22 µM -0.164545101281888 0.446464758838897 no 1877 0.434651022436811 2813 5401989
SGTC_136 0097-0015 404.482 µM -0.166661617497479 0.445779481162092 no 1878 0.433818153933624 2652 4861337
SGTC_2748 diazoxide 86.69 µM -0.167191865505571 0.445607824740357 no 1879 0.433609542359921 2790 3019 A potassium channel activatior.
SGTC_2060 5238662 140 µM -0.167899003847012 0.44537891973724 no 1880 0.433331366909609 2802 790130
SGTC_520 3584-0023 682 µM -0.167966640991832 0.445357026132987 no 1881 0.433304761406933 2778 1340790
SGTC_3193 9111931 49.47 µM -0.168771328660309 0.445096567957285 no 1882 0.432988255597797 2712 17087244
SGTC_71 0417-1750 47.813 µM -0.171425059282538 0.444237787301055 no 1883 0.431944775978717 2901 6811472
SGTC_1424 4048-1941 275 µM -0.173329945416951 0.443621503285514 no 1884 0.431196043437251 2821 X1424
SGTC_3293 9120939 62.045 µM -0.175993398938798 0.442760030368791 no 1885 0.430149564194733 2860 934087
SGTC_2935 9038016 29.96 µM -0.177226827038677 0.442361179240221 no 1886 0.42966511213228 2798 6463195
SGTC_3040 9091894 49.47 µM -0.177331209096955 0.442327428102404 no 1887 0.429624118967246 2732 25236966
SGTC_2224 6650123 117.647 µM -0.178036240750932 0.442099472500093 no 1888 0.429347257186618 2710 2908370
SGTC_2492 derrusnin 100 µM -0.178622247987837 0.441910015264255 no 1889 0.429117162033538 2687 1715307 Part of coumarin class of compounds.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.178675443858471 0.441892817596994 no 1890 0.429096275919558 2684 6708630 An antioxidant.
SGTC_1018 4259-0013 28.1 µM -0.182279036307388 0.440728070616657 no 1891 0.427681874839365 2890 6801262
SGTC_2046 4110841 106 µM -0.182322213957109 0.440714117898293 no 1892 0.427664933314487 2827 44119630 YMR134W ERG29
SGTC_1131 3454-3128 32.3 µM -0.183053664349166 0.440477763259521 no 1893 0.427377955932251 2914 710982
SGTC_1448 4255-0083 152 µM -0.183326205086109 0.440389702189254 no 1894 0.427271037066373 2898 5399660
SGTC_1606 st000094 49.2 µM -0.184077573075848 0.440146941766172 no 1895 0.426976299963163 2723 1242210
SGTC_1254 0550-0035 264 µM -0.18456090031943 0.439990794848 no 1896 0.426786728017291 2874 15121435
SGTC_2362 9071156 126 µM -0.185221274534559 0.43977746504867 no 1897 0.426527741563309 2909 653133
SGTC_234 nsc-17383 10.7 µM -0.185883613590251 0.439563518082395 no 1898 0.426268016353196 2824 408974
SGTC_266 formosanin C 406 nM -0.186282689349879 0.439434618229575 no 1899 0.426111540882117 2846 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2741 miltefosine 3.04 µM -0.186293379570298 0.439431165419956 no 1900 0.426107349463726 2763 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.186740770755932 0.439286667708327 no 1901 0.425931943953151 2705 5355888
SGTC_3171 9103192 49.47 µM -0.187024848858046 0.439194920801062 no 1902 0.425820575057084 2761 13018434
SGTC_1013 4112-3890 241 µM -0.187558733619867 0.439022504258985 no 1903 0.425611288926477 2728 705171
SGTC_719 2810-4230 27.3 µM -0.187665957800648 0.438987877913469 no 1904 0.425569258909188 2725 721079
SGTC_474 dl-dihydrosphingosine 5 µM -0.188736351845017 0.438642236802153 no 1905 0.425149729466415 2896 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2237 6667747 47.222 µM -0.188927486156447 0.438580522507087 no 1906 0.425074825331064 2766 729940 YDL015C TSC13
SGTC_839 0122-0028 230 µM -0.189267635872495 0.438470697151145 no 1907 0.424941529842769 2750 759448
SGTC_2112 5488546 200 µM -0.189811383718617 0.438295145182379 no 1908 0.424728467574288 2741 600757
SGTC_282 k297-0036 65.7 µM -0.190555231651717 0.438055009477086 no 1909 0.424437033674192 2886 5061378
SGTC_2586 curcumin 80 µM -0.191947312788547 0.437605666628323 no 1910 0.423891738096744 2867 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1261 0712-0010 12.7 µM -0.193000265891619 0.437265842617453 no 1911 0.423479379926406 2874 2840123
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.196066331014963 0.436276582897311 no 1912 0.422279124357111 2802 140250 A respiratory chain inhibitor.
SGTC_2401 5128683 200 µM -0.196342076338205 0.436187633663806 no 1913 0.42217121505092 2793 708373
SGTC_650 1328-0195 38 µM -0.19649123387738 0.436139520144289 no 1914 0.422112846643654 2760 2780821
SGTC_1058 3448-5425 97.3 µM -0.197679692696428 0.435756194617695 no 1915 0.421647839528446 2701 7279705
SGTC_3075 9116269 49.47 µM -0.197701747186956 0.435749081731191 no 1916 0.421639211319982 2943 17015205 YNL244C SUI1
SGTC_1650 st011916 45.8 µM -0.197775417942345 0.43572532201668 no 1917 0.421610389950515 2825 242528
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.197910377292824 0.435681796586769 no 1918 0.42155759243233 2746 229346 A bile salt which induces apoptosis.
SGTC_80 0159-0065 512.242 µM -0.198215230459304 0.435583481961067 no 1919 0.421438335857243 2716 1548079
SGTC_2532 xanthone 78.9 µM -0.202847791051844 0.434089982463508 no 1920 0.419627001252728 2877 7020 An insecticide.
SGTC_1118 chelidonine 707.474 nM -0.204156022972368 0.433668388582769 no 1921 0.419115788059577 2833 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2023 5144124 124 µM -0.206635488431525 0.432869557649415 no 1922 0.418147271298927 2796 2830192
SGTC_2847 9005661 71.43 µM -0.208348402576604 0.432317853192194 no 1923 0.417478470488507 2773 2991449
SGTC_1225 1216-0074 20.6 µM -0.210344948950092 0.431674961556996 no 1924 0.416699227869813 2805 4241466
SGTC_661 1304-0007 33.6 µM -0.211589152581168 0.431274417076899 no 1925 0.416213786359496 2788 3117130
SGTC_2472 5377652 49.4 µM -0.211761246146398 0.43121902082517 no 1926 0.416146651959285 2824 1610903
SGTC_1792 st045773 43.6 µM -0.213139257722875 0.430775493120039 no 1927 0.415609172422093 2772 2919270
SGTC_2835 9006588 71.43 µM -0.213969250890069 0.430508393067304 no 1928 0.415285518048548 3023 2345538
SGTC_2361 9034121 116 µM -0.214334042762643 0.430391009465214 no 1929 0.415143286269122 2814 6496917
SGTC_2812 7970281 58.44 µM -0.217285436182176 0.429441530102702 no 1930 0.413992953110737 2926 2233435
SGTC_3294 9122953 26.2835 µM -0.217605440278521 0.429338607460319 no 1931 0.413868272668706 2779 16459826
SGTC_2363 9053361 176 µM -0.217680289770616 0.429314534375418 no 1932 0.413839110957655 2942 6469797 YMR079W SEC14
SGTC_1916 st067606 49.2 µM -0.217922504003859 0.429236635264198 no 1933 0.41374474642057 2896 19590279
SGTC_151 3013-0144 2.285 µM -0.218627217313363 0.429010006378577 no 1934 0.413470224653048 3010 906558 YHR107C CDC12
SGTC_2598 perillyl alcohol 100 µM -0.219635541292873 0.428685779993286 no 1935 0.413077504628992 2950 10819 An apoptosis inducer.
SGTC_2871 9038510 12.99 µM -0.219731219183675 0.428655017281894 no 1936 0.413040244705258 2888 4945164
SGTC_3007 9078383 71.4286 µM -0.220017789544041 0.428562880707629 no 1937 0.412928650050024 2840 6496995
SGTC_1805 st050013 60.3 µM -0.220120905517539 0.428529728361918 no 1938 0.412888496915061 2853 4037144
SGTC_470 aa-861 153 µM -0.220504015621236 0.428406560801636 no 1939 0.412739322663573 2814 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3332 9141069 11.198 µM -0.220617185174747 0.428370178814509 no 1940 0.41269525945574 2779 17332883
SGTC_2652 actinonin 100 µM -0.220976752391267 0.428254588427622 no 1941 0.412555267222686 2778 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_120 rhodamine 6G 52.259 µM -0.22173840697116 0.428009759006019 no 1942 0.41225876491531 2787 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2990 9074105 71.4286 µM -0.221754191941302 0.428004685312235 no 1943 0.412252620559004 2838 6502001
SGTC_180 1486-1293 102.781 µM -0.221987632323373 0.427929652983248 no 1944 0.412161755563843 2875 4140536
SGTC_2546 rhodinyl acetate 100 µM -0.223328947289674 0.427498578564094 no 1945 0.411639749727559 2839 6708682
SGTC_1763 st044482 94.5 µM -0.223641941328397 0.427398000364014 no 1946 0.411517962834912 2942 88505
SGTC_2273 7815444 169.05 µM -0.22553824010707 0.42678874062379 no 1947 0.410780290139416 3003 2824616
SGTC_2282 7944268 200 µM -0.226511345907649 0.426476160242225 no 1948 0.410401867888317 2999 2970414
SGTC_1155 4088-0394 48.2 µM -0.226698729261306 0.42641597438513 no 1949 0.410329007648586 2773 2326248
SGTC_1507 4075-3230 155 µM -0.227765779385472 0.426073280132235 no 1950 0.409914165783335 2758 659771
SGTC_291 SEC14.278 35.5 µM -0.231002318936168 0.42503417423694 no 1951 0.408656500249687 2917 1068044
SGTC_509 pifithrin 175 µM -0.231637075587614 0.424830443535926 no 1952 0.408409954210126 2852 4817 A p53 inhibitor.
SGTC_3278 9139605 49.47 µM -0.231762825674967 0.424790085326093 no 1953 0.408361115876176 3018 7958859
SGTC_1222 0366-0074 1.18 µM -0.232137458371897 0.424669855451901 no 1954 0.408215625913646 2956 286520
SGTC_99 0109-0120 622.8 µM -0.23222015577772 0.424643316537413 no 1955 0.408183511781073 2901 759414
SGTC_1348 1493-0373 93.8 µM -0.232240721155036 0.42463671683336 no 1956 0.40817552566193 2879 3010129
SGTC_2994 9053520 71.4286 µM -0.232371295966662 0.424594814126609 no 1957 0.408124820650171 2962 4647384
SGTC_2638 epoxomicin 18 µM -0.232506918653801 0.424551292410507 no 1958 0.408072157068458 2927 9915668 A protesome inhibitor.
SGTC_2680 butyl paraben 22.24 µM -0.233717691340763 0.424162792743831 no 1959 0.407602076193297 2795 7184 An antifungal and steroid mimetic.
SGTC_2058 5236698 133 µM -0.236438523926104 0.423290030739826 no 1960 0.406546202839408 2850 766665
SGTC_687 k029-0044 34.9 µM -0.236787433093089 0.423178138207508 no 1961 0.406410850644425 2963 5829338
SGTC_2110 5483698 200 µM -0.238493834838499 0.422630997481918 no 1962 0.405749048254399 2876 2848765 YHR062C RPP1
SGTC_111 0083-0039 52.457 µM -0.240029109857263 0.422138854337256 no 1963 0.405153844877282 2799 759313
SGTC_1408 3909-7976 48.8 µM -0.241190565642155 0.421766622278667 no 1964 0.404703711311727 2867 24152374
SGTC_2453 5731132 22.18 µM -0.241927677558636 0.421530423354839 no 1965 0.404418101731065 2979 1362040
SGTC_2839 9003951 25.97 µM -0.24628914725767 0.420133421700353 no 1966 0.402729205242329 2877 2990634
SGTC_623 k072-0108 16.9 µM -0.247564317572316 0.419725167153319 no 1967 0.402235760922029 2918 5382803
SGTC_1438 4092-1045 4 µM -0.247571940673269 0.419722726824424 no 1968 0.402232811528064 2847 1351342
SGTC_2260 7964312 200 µM -0.249040902218824 0.419252536371913 no 1969 0.401664571257121 3016 231951
SGTC_3231 9132313 49.47 µM -0.250037106528734 0.418933733303446 no 1970 0.401279326472043 2901 4905967
SGTC_3316 9136639 10.545 µM -0.252015999506125 0.41830061048174 no 1971 0.40051434851908 2944 4903665
SGTC_2857 9024691 58.44 µM -0.253441461719267 0.417844682147855 no 1972 0.399963545701591 2953 16478292
SGTC_1995 st072814 61.1 µM -0.254310893776949 0.417566651977334 no 1973 0.399627692195292 2866 5769371
SGTC_373 0844-0104 25.9 µM -0.25447824399271 0.417513140836463 no 1974 0.39956305487973 2986 5375804
SGTC_2056 5235370 200 µM -0.256628945730576 0.416825578566551 no 1975 0.398732613847083 2890 5511916
SGTC_2608 thymoquinone 42.66 µM -0.256835518621722 0.416759552208153 no 1976 0.398652874824885 2874 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_979 1426-2828 121 µM -0.258015774952323 0.416382355020977 no 1977 0.398197366335525 3007 747872
SGTC_1849 st056239 19.2 µM -0.25902712786228 0.416059198782044 no 1978 0.397807154802326 2862 5393181
SGTC_500 h-89 112 µM -0.259461936339412 0.415920282441562 no 1979 0.397639423510178 3055 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1668 st014914 51.6 µM -0.259923427558876 0.415772852761746 no 1980 0.397461419809273 2910 2839556
SGTC_2701 st077767 14.721 µM -0.264736138730399 0.414236076535433 no 1981 0.395606367881633 2904 5721188
SGTC_1830 st055982 50.3 µM -0.26483321800217 0.41420509098205 no 1982 0.395568972998404 2954 455313 An antimicrobial agent.
SGTC_2019 4016004 108 µM -0.267192103486854 0.413452351557131 no 1983 0.39466062785729 2952 45595336
SGTC_149 3970-0822 46.1 µM -0.267383466520613 0.413391299973846 no 1984 0.394586963990137 2875 3114250 YBL034C STU1
SGTC_1501 4491-0275 38.4 µM -0.268470182924708 0.413044638716409 no 1985 0.394168711629178 2940 5104718
SGTC_2766 oltipraz 83.91 µM -0.269386279996782 0.412752457475855 no 1986 0.393816221517297 3026 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2186 6124449 200 µM -0.270522594205814 0.412390107055769 no 1987 0.393379118514635 3039 3834182 YLR033W RSC58
SGTC_951 1171-0579 82.7 µM -0.271181897997343 0.412179900992744 no 1988 0.393125567410395 2830 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2605 digitonin 300 nM -0.271716570860544 0.412009449549217 no 1989 0.392919979403112 3000 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_327 1273-0057 3.96 µM -0.272971608490923 0.411609414134741 no 1990 0.392437520091034 2933 3108138
SGTC_2729 fluphenazine 10.66 µM -0.275239923999992 0.410886636036326 no 1991 0.391565958049763 2883 3372 An atypical antipsychotic.
SGTC_1086 cerivastatin 2.18 µM -0.276854352417345 0.410372397197777 no 1992 0.390945972229594 2897 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1227 3909-8010 46.6 µM -0.277014725955134 0.410321322313779 no 1993 0.39088439939344 2905 15982272
SGTC_1376 2910-0861 41.3 µM -0.278862197703592 0.409733059550208 no 1994 0.390175290003538 2871 1112859
SGTC_2456 5770359 74.46 µM -0.279190906024661 0.409628415130964 no 1995 0.390049161109863 3041 3118787
SGTC_2531 methyl deoxycholate 70.07 µM -0.279496133876526 0.409531251492089 no 1996 0.389932052286685 2887 16667744 Haematoxylin.
SGTC_1355 1499-0035 1.68 µM -0.2800846447118 0.409343925647195 no 1997 0.389706282584975 2900 1548538
SGTC_1974 st069448 26.9 µM -0.280689154319664 0.409151528865504 no 1998 0.389474414036454 3045 6323587 YNR016C ACC1
SGTC_2304 7443016 91.4 µM -0.281721971710584 0.408822865571036 no 1999 0.389078352806843 2834 939854
SGTC_1864 st057645 30.4 µM -0.283531291932635 0.408247258077854 no 2000 0.388384798933104 2953 688666
SGTC_1618 st003135 44.5 µM -0.284549291568091 0.407923484026783 no 2001 0.387994732594969 2867 1270615
SGTC_2464 5717415 7.67 µM -0.28466571202611 0.407886460585791 no 2002 0.387950131026437 2921 5285744
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.287795807879047 0.406891352821597 no 2003 0.386751523251067 3080 5393153
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.288844355879375 0.406558136589605 no 2004 0.386350243499349 2959 688788
SGTC_133 0724-0033 378.92 µM -0.289198170297007 0.406445713778584 no 2005 0.386214865975513 2839 280309
SGTC_831 k061-1017 217 µM -0.289676699529578 0.406293675710699 no 2006 0.386031791737126 2983 1240153
SGTC_2664 lyso-paf C-16 73.48 µM -0.294017409131814 0.404915195643732 no 2007 0.384372300229731 2925 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1957 st077035 62.4 µM -0.294062173209593 0.40490098601926 no 2008 0.384355197505718 3031 705593
SGTC_1033 k072-0102 21.3 µM -0.29458281129178 0.404735727189028 no 2009 0.384156297198149 3097 5965931
SGTC_2667 digitoxin 100 µM -0.295279727560693 0.40451454144968 no 2010 0.383890100768299 2996 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3347 9188721 44.724 µM -0.295517116748047 0.404439206359291 no 2011 0.383799439314077 2994 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2731 amoxapine 43.43 µM -0.298200225108353 0.403587973042415 no 2012 0.382775174996049 2982 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2261 9010538 184.68 µM -0.299658138684574 0.403125631772086 no 2013 0.382218966234888 3045 6457250
SGTC_763 3453-1109 128 µM -0.300339060737411 0.402909740512641 no 2014 0.381959270756129 3094 1560353
SGTC_2 0422-0095 29 µM -0.301047666955275 0.402685103215655 no 2015 0.38168907325818 2979 6790840
SGTC_2297 7971671 152.32 µM -0.301284009225067 0.402610186812674 no 2016 0.381598966778033 3111 909016
SGTC_1735 st034310 56.75 µM -0.30165830124033 0.402491550048864 no 2017 0.381456279507658 3120 871153
SGTC_1676 st018489 23.4 µM -0.302182781227481 0.402325324347029 no 2018 0.381256364818602 2953 3696235
SGTC_2497 7-hydroxyflavone 100 µM -0.302678250188767 0.402168309456423 no 2019 0.381067537288426 3103 5281894
SGTC_2582 agaric acid 100 µM -0.302750491747361 0.402145417311231 no 2020 0.381040007766443 3054 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3059 1327-0034 3 µM -0.303821366629066 0.401806114325386 no 2021 0.380631993767151 2945 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_39 0986-0283 58.349 µM -0.303937854085845 0.401769210137597 no 2022 0.380587618882093 3127 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_193 1273-0060 1.558 µM -0.304669975881268 0.401537287975224 no 2023 0.380308759430404 2928 2847393 YHR072W ERG7
SGTC_1465 k213-0056 144 µM -0.304765033528443 0.401507178075177 no 2024 0.380272557276849 2911 24048857 YMR208W ERG12
SGTC_1276 0871-0068 94.2 µM -0.305250518287185 0.40135340790816 no 2025 0.380087679585141 3024 3414906
SGTC_328 k915-0120 63.5 µM -0.305456670279146 0.401288116911775 no 2026 0.380009183027022 3057 6624543
SGTC_1798 st045719 60.953 µM -0.305890675529838 0.401150670859192 no 2027 0.379843942872953 2960 3980186
SGTC_1040 k898-0338 155 µM -0.305918550830565 0.401141843388376 no 2028 0.379833330573347 3151 20969351
SGTC_442 cape 100 µM -0.305998572748332 0.401116502555839 no 2029 0.379802866236522 3070 5281787
SGTC_1260 0700-1617 7.75 µM -0.307496229068072 0.400642311125762 no 2030 0.379232846429247 3065 2853078
SGTC_2351 9026858 72.31 µM -0.307704322669053 0.400576435612579 no 2031 0.379153665103619 2917 1409300
SGTC_2810 7959871 45.46 µM -0.308128555859588 0.400442146254522 no 2032 0.378992256594529 3042 2974535
SGTC_476 mead acid 10 µM -0.308287139357042 0.400391950289196 no 2033 0.378931925557619 2930 5312531 An omega 9 fatty acid.
SGTC_1891 st059073 26.2 µM -0.308810654736566 0.400226255199127 no 2034 0.378732781861802 3133 688754
SGTC_1032 k061-1018 98.7 µM -0.31252333607744 0.39905169093489 no 2035 0.377321415472124 3157 4005393
SGTC_2316 5844804 197.44 µM -0.312561936427724 0.399039483895618 no 2036 0.377306750213053 3076 776813
SGTC_2662 daunorubicin 22.37 µM -0.31415936201512 0.398534398085002 no 2037 0.376700002832647 2945 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1020 4335-0961 93.3 µM -0.319136967438251 0.396961635283636 no 2038 0.374811326096028 2924 669075
SGTC_1295 1013-0063 9.78 µM -0.320263614762414 0.39660588253037 no 2039 0.374384251449998 3081 6826038
SGTC_1906 st060206 94.7 µM -0.321737647074551 0.396140568672873 no 2040 0.37382572740133 3114 5133468
SGTC_1887 st057648 70.8 µM -0.321782093819436 0.396126540279913 no 2041 0.373808890238982 3101 688672
SGTC_161 4065-0411 162.148 µM -0.32236842754934 0.395941492757224 no 2042 0.373586799873757 3091 1906281 YLR208W SEC13
SGTC_145 3737-0113 38.366 µM -0.322465446196417 0.395910875833186 no 2043 0.373550055382238 3103 6849351
SGTC_554 4483-2211 187 µM -0.322587431888716 0.395872380777124 no 2044 0.373503856593687 3060 747107
SGTC_2119 5528445 120.635 µM -0.32409171251581 0.395397758146015 no 2045 0.37293430053261 3117 791935
SGTC_3039 9090270 49.47 µM -0.32559939884592 0.394922216598612 no 2046 0.37236373354155 3112 17173750
SGTC_2375 9072683 200 µM -0.325903800925933 0.394826223658535 no 2047 0.372248569924972 3145 16798029
SGTC_525 k781-2675 26.7 µM -0.3268451824686 0.394529400206422 no 2048 0.371892491927135 2995 3651118 YDL195W SEC31
SGTC_2215 7188065 200 µM -0.327383297171035 0.394359756785962 no 2049 0.371688998982931 3098 940217
SGTC_1722 st034304 3.6505 µM -0.327677061847642 0.394267154417018 no 2050 0.371577924334745 2984 4036148 YLR033W RSC58
SGTC_224 benfluorex 43.875 µM -0.329629389584127 0.393651881325069 no 2051 0.370840006484468 3091 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1565 sinapyl alcohol 95.1 µM -0.330836740429156 0.393271519281364 no 2052 0.370383903636359 3080 5280507 A phenol propionate derived from cinnamic acid.
SGTC_398 bronopol 33.3 µM -0.331304835917882 0.393124078542174 no 2053 0.370207119426384 2956 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_699 0375-0592 111 µM -0.331658031024821 0.393012839276379 no 2054 0.370073747440985 3125 762578
SGTC_3079 9117512 49.47 µM -0.333638638812048 0.392389206329583 no 2055 0.369326128879103 3025 7185044
SGTC_1384 3089-0840 101 µM -0.334381149132269 0.392155483597202 no 2056 0.369045981193803 3121 1069836
SGTC_1796 st049173 110.4 µM -0.334802132194095 0.392022986470302 no 2057 0.368887175996495 3105 94134
SGTC_2328 6201408 200 µM -0.337205726388424 0.391266737071734 no 2058 0.367980910405341 3127 2890418
SGTC_1278 0874-0585 172 µM -0.337640932854653 0.391129850723316 no 2059 0.36781689591796 3071 766306
SGTC_1067 clotrimazole 1.36 µM -0.337916480178332 0.391043189250821 no 2060 0.367713063978603 3017 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2157 5649910 96.377 µM -0.338093803153528 0.390987422852163 no 2061 0.367646250120467 2996 2858091
SGTC_3223 9129970 49.47 µM -0.341645953265833 0.389870778869221 no 2062 0.366308675057161 2959 17248386
SGTC_1387 3342-1166 1.8 µM -0.343011754249092 0.389441670743984 no 2063 0.365794808706969 3052 3418228
SGTC_889 0919-1524 82.7 µM -0.343367540136237 0.389329911837401 no 2064 0.365660987985526 3070 3905452
SGTC_981 1488-1094 54.9 µM -0.344173007589492 0.389076933492028 no 2065 0.365358090251063 2953 3449522
SGTC_616 4092-0450 108 µM -0.344399881103287 0.389005686349775 no 2066 0.365272789134755 3061 787165
SGTC_2921 7974240 10.71 µM -0.34484168389829 0.388866953733485 no 2067 0.36510669688837 3139 2979074 YDR527W RBA50
SGTC_2965 9082772 38.63 µM -0.347552791617068 0.388015936686457 no 2068 0.364088032610895 3209 16459634
SGTC_579 4491-1009 110 µM -0.347928968166757 0.387897897194232 no 2069 0.363946764697558 3141 1271041
SGTC_1889 st059080 5.18 µM -0.34971061127942 0.387338980759807 no 2070 0.363277944646298 3194 176925 Isolated from Daphnopsis sellowiana.
SGTC_2216 7189485 200 µM -0.349900955068293 0.387279282094175 no 2071 0.363206515123049 3127 731273
SGTC_488 nitrendipine 139 µM -0.350041240365298 0.387235285280215 no 2072 0.363153873887088 3021 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3140 9094243 49.47 µM -0.350961455083843 0.386946719942412 no 2073 0.362808632836296 3103 19291112
SGTC_1824 st053723 68.6 µM -0.351583697207773 0.386751629675062 no 2074 0.362575246651956 3081 675225
SGTC_3099 9120367 49.47 µM -0.352033091660795 0.386610749767391 no 2075 0.362406722697468 3002 24824940
SGTC_3282 9108498 15.4605 µM -0.352955663208718 0.38632158121531 no 2076 0.362060839816201 3106 16459645
SGTC_615 k087-0205 167 µM -0.353237974662757 0.386233106815708 no 2077 0.361955020434921 3039 9642773
SGTC_2078 5212016 200 µM -0.353469538137116 0.386160540887278 no 2078 0.361868230899954 3080 1899708
SGTC_1617 st002906 78 µM -0.35376707638921 0.386067306037287 no 2079 0.361756724576137 3005 5150859
SGTC_1302 1159-0335 255 µM -0.355132859612135 0.385639416675691 no 2080 0.361245030293907 3031 649284
SGTC_2093 5331342 194.4 µM -0.355179826039734 0.385624704927356 no 2081 0.361227438606345 3170 33839
SGTC_2771 fluoxetine 41.05 µM -0.35725432543065 0.3849750538484 no 2082 0.360450709884649 3220 3386 A selective serotonin reuptake inhibitor.
SGTC_1620 st003704 16.5 µM -0.357828990475158 0.384795148517935 no 2083 0.360235646934647 3166 2834414
SGTC_423 5-fluorouracil 457 µM -0.358753520851179 0.384505765989217 no 2084 0.359889743020817 2955 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1674 st016616 23.6 µM -0.359541562921127 0.384259155759981 no 2085 0.359594995407365 2998 625830
SGTC_2416 tofa 880 nM -0.360684547861448 0.383901552822349 no 2086 0.359167638633124 3035 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2158 5657123 3.6195 µM -0.361064567228445 0.383782678958822 no 2087 0.359025590146329 3046 2858827
SGTC_2212 7123476 200 µM -0.363124901051536 0.383138376541585 no 2088 0.358255792014851 3060 1085715
SGTC_3227 9130768 49.47 µM -0.363170752200489 0.383124041754627 no 2089 0.358238667285973 3054 17720899
SGTC_349 k015-0014 24 µM -0.363452776369328 0.383035873953858 no 2090 0.35813334168463 2982 2196908
SGTC_7 0192-1582 4.227 µM -0.364858253773634 0.382596577029878 no 2091 0.357608608932502 3086 252616
SGTC_957 1187-1561 14.1 µM -0.366214213852001 0.382172900394018 no 2092 0.357102618349401 3130 1538454
SGTC_1814 st052110 31.539 µM -0.366663399629825 0.382032581084371 no 2093 0.356935055362595 3183 674163
SGTC_2029 5175081 200 µM -0.366676643850236 0.382028444011551 no 2094 0.356930115194904 3034 1380876
SGTC_544 k015-0020 52.4 µM -0.366867271827179 0.381968899392791 no 2095 0.356859012560021 3096 3008304
SGTC_2015 5119600 184 µM -0.367219212076314 0.381858974555185 no 2096 0.35672775486795 3218 2828786
SGTC_2878 9043973 25.97 µM -0.368404536914821 0.381488820909888 no 2097 0.356285807512357 3178 6465167
SGTC_1393 3470-5649 58.2 µM -0.36912141841938 0.381265005474362 no 2098 0.356018612455213 3107 4108395
SGTC_2974 9094440 9.66 µM -0.369580806999825 0.381121602006566 no 2099 0.355847426954269 3213 25236134
SGTC_1272 0839-0021 27 µM -0.370852515230361 0.380724708744738 no 2100 0.355373692207236 3139 5027250
SGTC_288 1315-0019 35.1 µM -0.372116594417997 0.380330320820601 no 2101 0.354903020780235 3150 6811474
SGTC_1747 st037496 66.6 µM -0.374361154923085 0.379630333150291 no 2102 0.354067819564924 3066 723305
SGTC_2674 ligustilide 100 µM -0.374545615639963 0.37957282481328 no 2103 0.353999212856468 3140 5319022 A signalling regulator.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.374649059708481 0.37954057577176 no 2104 0.35396074084702 3096 6708561
SGTC_218 alverine citrate 93.75 µM -0.374650397400231 0.379540158747278 no 2105 0.353960243354217 3193 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1369 1866-0067 208 µM -0.375578323284346 0.379250912280266 no 2106 0.353615204197734 3206 3531355
SGTC_2923 7992654 58.14 µM -0.376850500959188 0.378854467959339 no 2107 0.353142354212334 3092 2985126
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.378077871586364 0.378472107462068 no 2108 0.352686373155897 3034 23665772 A membrane-active detergent.
SGTC_3262 9137218 49.47 µM -0.378367632371796 0.378381856164017 no 2109 0.352578754830512 3009 17650664
SGTC_1104 tacrolimus 29.8 µM -0.379056605101716 0.378167289650884 no 2110 0.352322914969345 3118 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_230 MPP+ 141.667 µM -0.379746568140478 0.377952452375855 no 2111 0.352066774322079 3117 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2970 9090938 41.86 µM -0.379799357216237 0.377936016728163 no 2112 0.352047179761899 3256 17217104
SGTC_3162 9099653 49.47 µM -0.381104898195057 0.377529612628206 no 2113 0.351562706485696 3198 25237511
SGTC_3174 9107204 49.47 µM -0.383430750983668 0.376805930040117 no 2114 0.350700203189094 3200 3938802
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.38412178969872 0.376590998529329 no 2115 0.350444091102539 3207 5024745
SGTC_1353 1498-1206 8.11 µM -0.384312979644984 0.376531540098439 no 2116 0.350373244473718 3125 6756808
SGTC_1504 k297-0033 30 µM -0.385299192841703 0.376224882820145 no 2117 0.350007879739911 3021 4388117
SGTC_1649 st011737 51.3 µM -0.38890709095696 0.375103694823811 no 2118 0.348672438241367 3138 1761035
SGTC_101 0490-5701 117.494 µM -0.389709704212575 0.37485441831847 no 2119 0.348375609927655 3171 4661669
SGTC_807 1315-0151 48 µM -0.389757627298054 0.37483953596684 no 2120 0.348357889596354 3300 4011080
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.391579527582414 0.374273889436236 no 2121 0.34768445846986 3169 4213774
SGTC_815 1582-0027 36.9 µM -0.392157646658444 0.374094456926308 no 2122 0.347470867929036 3177 3128206
SGTC_102 gallobenzophenone 83.616 µM -0.392839668207151 0.373882810971766 no 2123 0.347218952078313 3271 70837
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.39451420876613 0.373363326407736 no 2124 0.346600719507027 3138 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_935 2996-0153 430 µM -0.396810802988871 0.372651239465119 no 2125 0.345753491879692 3235 23738523
SGTC_2487 5918373 44.05 µM -0.39815923482789 0.372233344322352 no 2126 0.345256406486612 3264 2876279
SGTC_160 3453-0671 289.699 µM -0.398740405666249 0.372053278890634 no 2127 0.345042246126464 3099 5322268
SGTC_1223 0764-0573 147 µM -0.399162856630596 0.371922407541722 no 2128 0.344886604882931 3111 1609797
SGTC_66 0109-0187 42.4 µM -0.399882867721086 0.371699388962252 no 2129 0.344621395720914 3170 759417
SGTC_3233 9132340 49.47 µM -0.400828969499918 0.371406405778221 no 2130 0.344273024319339 3105 17682950
SGTC_1886 st057356 49.9 µM -0.401317598505621 0.371255119207669 no 2131 0.344093154189271 3099 24207747
SGTC_972 1319-0219 195 µM -0.401801099344466 0.37110543996982 no 2132 0.343915206513078 3163 23903702
SGTC_811 0416-0114 265 µM -0.402261583355632 0.370962904266777 no 2133 0.343745762088549 3212 6612453
SGTC_2860 9025725 38.96 µM -0.402734532289261 0.370816528667462 no 2134 0.343571763613404 3051 40546248
SGTC_210 3551-0445 56.827 µM -0.405010476800874 0.370112395696623 no 2135 0.342734904944921 3240 2865180 YOR207C RET1
SGTC_1072 oxiconazole 14.9 nM -0.405055613225049 0.370098435757265 no 2136 0.342718316188616 3183 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3336 9143619 71.43 µM -0.405195080146164 0.370055302057912 no 2137 0.342667060549609 3245 45595730
SGTC_1628 st004252 77.7 µM -0.405727079870239 0.369890782598562 no 2138 0.34247157135958 3243 692968
SGTC_2450 5739737 12.93 µM -0.406167501684743 0.369754601370109 no 2139 0.342309765406689 3204 2262825
SGTC_2469 5655019 90.81 µM -0.407002119076648 0.369496577177102 no 2140 0.342003215906091 3239 2788239
SGTC_2168 5727979 200 µM -0.407216443504036 0.369430327686925 no 2141 0.341924512741565 3137 695210
SGTC_1509 1326-1131 80 µM -0.408312160701649 0.369091692862477 no 2142 0.341522256233502 3214 768313
SGTC_890 0929-0006 47.2 µM -0.409018889277327 0.368873330055819 no 2143 0.341262899522667 3118 1378169
SGTC_2967 9089538 49.85 µM -0.412411964931896 0.367825538533705 no 2144 0.340018747402689 3320 728216
SGTC_600 1495-0418 41.6 µM -0.412470320562436 0.367807526722171 no 2145 0.339997365102868 3129 5377768
SGTC_865 0488-0499 301 µM -0.41397295933451 0.367343828571111 no 2146 0.339446955160779 3285 9634651
SGTC_1 0258-0098 57.368 µM -0.415271704172612 0.366943205662185 no 2147 0.338971506390524 3173 6790032 YDR047W HEM12
SGTC_2214 7179297 48.276 µM -0.415373814541811 0.366911713885092 no 2148 0.338934136352968 3157 769744
SGTC_982 1491-0518 27.5 µM -0.415540156005912 0.366860414565449 no 2149 0.338873262611887 3131 3091256
SGTC_2364 9055074 200 µM -0.415696249052904 0.366812277996074 no 2150 0.338816143172386 3212 6470630
SGTC_1136 pergolide 1.05886 µM -0.415987821617737 0.366722367346393 no 2151 0.33870945737138 3084 47811 A dopamine receptor agonist.
SGTC_147 4466-0538 29.23 µM -0.416912201099377 0.36643736982026 no 2152 0.338371314394984 3340 6742687 YHR072W ERG7
SGTC_92 0063-0024 660.874 µM -0.417222847608085 0.366341610217601 no 2153 0.338257707472553 3185 3594437
SGTC_1666 st014829 29 µM -0.417577873897176 0.366232180335582 no 2154 0.338127888394689 3126 3858230
SGTC_1429 4049-0205 9.46 µM -0.417899708194295 0.366132990632692 no 2155 0.338010222945388 3200 22774478
SGTC_1496 4469-0713 57.4 µM -0.419719461817249 0.365572308913365 no 2156 0.337345203010371 3249 746691
SGTC_3088 9117578 49.47 µM -0.420589812032392 0.365304247955194 no 2157 0.337027317223294 3247 678341
SGTC_2964 9083345 53.42 µM -0.421309417400168 0.365082664891873 no 2158 0.336764577178268 3177 17741579
SGTC_1603 st002045 67.8 µM -0.422123491348386 0.364832047079184 no 2159 0.336467441082873 3264 5887985
SGTC_256 clotrimazole 625 nM -0.422876208101918 0.364600369841756 no 2160 0.336192791130713 3201 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1405 3909-7894 12 µM -0.423687947700489 0.364350581489044 no 2161 0.335896702989953 3240 7104060
SGTC_3320 9137005 35.139 µM -0.425886319818647 0.363674388340469 no 2162 0.335095341882381 3190 4908713
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.428180638960184 0.36296913561955 no 2163 0.334259805494484 3264 688662
SGTC_444 curcumin 90.4 µM -0.429301736627466 0.362624689224147 no 2164 0.333851826591206 3267 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1728 st035614 33.7865 µM -0.430055770722022 0.36239308205451 no 2165 0.333577536268591 3201 15945546
SGTC_1530 rhein 70.4 µM -0.430208067192111 0.362346309173019 no 2166 0.333522147113703 3199 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1184 1269-1718 139 µM -0.431093741191403 0.36207434410299 no 2167 0.333200105659891 3295 5403821
SGTC_2153 5569715 200 µM -0.431962654854401 0.36180759330568 no 2168 0.332884277926783 3218 2054701
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.431986592341846 0.361800245603551 no 2169 0.332875578943354 3189 364106
SGTC_2523 spermine 47.74 µM -0.434754805621568 0.360950876341453 no 2170 0.331870206349646 3247 1103 A DNA binding polyamine.
SGTC_2244 6635614 200 µM -0.435066635519649 0.360855240622944 no 2171 0.331757030179023 3035 836499
SGTC_1634 st006576 41 µM -0.436138612176896 0.360526540407034 no 2172 0.331368081979533 3339 3915356
SGTC_1242 0402-0103 60.1 µM -0.436806001615656 0.360321950801042 no 2173 0.3311260230623 3134 432868
SGTC_1002 4049-0206 172 µM -0.436859892313354 0.360305432240916 no 2174 0.331106480244685 3156 4662749
SGTC_2833 9001315 45.46 µM -0.4370069118921 0.360260369170907 no 2175 0.331053167690917 3107 2989378
SGTC_756 0508-1999 28.3 µM -0.438363109369068 0.359844771794935 no 2176 0.330561542110946 3161 6753853
SGTC_688 0527-0193 473 µM -0.439190557155584 0.359591287452532 no 2177 0.330261733323445 3181 4007154
SGTC_2380 9035439 200 µM -0.439453137754166 0.359510860151247 no 2178 0.330166615373602 3317 6462575
SGTC_2607 solasodine 47.35 µM -0.440070432639366 0.359321809914689 no 2179 0.329943047940258 3175 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_364 0083-0097 67.7 µM -0.440155774955486 0.359295676030264 no 2180 0.329912144048841 3296 5207356
SGTC_3315 9136395 68.55 µM -0.440867809517664 0.35907765946733 no 2181 0.329654349593458 3354 16876844
SGTC_1281 0884-0031 11.8 µM -0.441719572736818 0.358816919924168 no 2182 0.329346072214739 3201 1548255
SGTC_1200 1643-0193 18.4 µM -0.443877155323251 0.358156740920949 no 2183 0.328565700927072 3293 5403974
SGTC_56 0957-0365 83.25 µM -0.444465220210739 0.357976877738173 no 2184 0.32835313445953 3287 6752360
SGTC_1876 myriocin 605 nM -0.444754907408118 0.357888286752532 no 2185 0.328248442311442 3327 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3109 9122853 49.47 µM -0.445213293511005 0.357748120577264 no 2186 0.328082810406958 3229 1234709
SGTC_814 3342-0569 96 µM -0.445884647781936 0.357542867211242 no 2187 0.327840286211296 3305 4346283
SGTC_2246 7293507 91.5585 µM -0.448240749387086 0.356822861814041 no 2188 0.326989728365445 3285 887656
SGTC_167 3672-0051 66.205 µM -0.44891140849929 0.356618006961223 no 2189 0.326747782941241 3153 3237971
SGTC_122 0236-0016 402.397 µM -0.450741448168392 0.3560592263407 no 2190 0.326087952846031 3243 6808838
SGTC_1982 st072467 71.9 µM -0.45188496265367 0.355710224724791 no 2191 0.325675928969839 3147 3163533
SGTC_1672 st016598 6.51 µM -0.45217714112415 0.355621070984165 no 2192 0.325570687203087 3205 4665860 YNL267W PIK1
SGTC_112 phenothiazine 287.218 µM -0.452260192593737 0.355595730554281 no 2193 0.325540774862128 3336 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2826 7992541 19.48 µM -0.452996303594061 0.355371158353655 no 2194 0.325275701611204 3267 2985066
SGTC_181 1447-1644 8.07 µM -0.453061322313882 0.355351324902838 no 2195 0.325252292644541 3271 534600
SGTC_1413 3910-0535 34.4 µM -0.453171459274657 0.355317729380183 no 2196 0.325212641138774 3313 2876951
SGTC_2537 larixol 68.93 µM -0.455082898312321 0.354734854687998 no 2197 0.324524800446689 3300 6708759
SGTC_2006 4011487 200 µM -0.455237195242939 0.354687818153154 no 2198 0.324469302001886 3350 45595294
SGTC_3284 9108171 64.8615 µM -0.455833000880464 0.354506211019511 no 2199 0.32425503565674 3251 8687505
SGTC_1954 st077032 68.9 µM -0.457580066138958 0.353973879977627 no 2200 0.323627083737817 3259 698907
SGTC_124 0136-0217 7.121 µM -0.45792569737063 0.3538685998632 no 2201 0.323502912071405 3386 3976905
SGTC_3258 9138477 49.47 µM -0.459430341214867 0.353410411971656 no 2202 0.32296258203551 3250 4970355
SGTC_217 ketoconazole 989 nM -0.460156586169918 0.353189334818314 no 2203 0.322701915018369 3280 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1231 0242-0792 125 µM -0.461363337815895 0.352822095583235 no 2204 0.32226897508939 3187 3707635
SGTC_2508 celastrol 40.54 µM -0.46152558458828 0.352772731015444 no 2205 0.322210785036181 3246 122724 Celastrol is a natural product and antioxidant.
SGTC_2514 salinomycin 42.74 µM -0.461921480806801 0.352652287586397 no 2206 0.322068814541255 3340 23682228 A polyether potassium ionophore.
SGTC_1503 4585-0012 61.3 µM -0.464563897531124 0.351848764444747 no 2207 0.321121895549995 3355 2922052
SGTC_2499 avocadenofuran 51.48 µM -0.464937231842395 0.351735291767028 no 2208 0.320988203474221 3180 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_244 nsc-207895 1.295 µM -0.465705033838033 0.351501964572875 no 2209 0.320713324350496 3197 42640
SGTC_1710 st031758 61.5 µM -0.46579994834319 0.351473124906329 no 2210 0.32067935103712 3374 5394341
SGTC_1725 st036284 20.55 µM -0.466064250876028 0.351392821382186 no 2211 0.320584755574738 3381 707914
SGTC_1482 3346-2049 8.48 µM -0.467746745906996 0.350881781466043 no 2212 0.319982853894265 3312 3826804
SGTC_1157 4092-0394 27.6 µM -0.467762741068436 0.350876924398864 no 2213 0.319977133999066 3410 3659885
SGTC_1182 1222-0449 220 µM -0.470801001781279 0.349954773362633 no 2214 0.318891424545892 3292 658318
SGTC_179 1273-0063 6.77 µM -0.472920270959079 0.349312071151194 no 2215 0.318135031099886 3199 3108139
SGTC_876 0720-0963 56.8 µM -0.473295321112096 0.349198376127449 no 2216 0.318001249886813 3394 765861
SGTC_1843 st055809 45.5 µM -0.474923501099014 0.348704956584146 no 2217 0.317420749996698 3319 16413835
SGTC_1273 0849-0096 14.1 µM -0.475730943180088 0.348460356291101 no 2218 0.317133036613314 3274 5286025
SGTC_2989 9073649 71.4286 µM -0.476744579637321 0.348153382252531 no 2219 0.316772007057362 3358 21367202
SGTC_1419 3993-2473 62.6 µM -0.476887231005596 0.348110189075959 no 2220 0.316721212539543 3286 704026
SGTC_3006 9075424 71.4286 µM -0.4773954566211 0.347956320283668 no 2221 0.316540274436347 3239 7465181
SGTC_780 0109-0199 192 µM -0.485537027411488 0.345494831692488 no 2222 0.313647726920428 3394 610414
SGTC_1333 1482-0047 286 µM -0.485629186690739 0.345467005764628 no 2223 0.313615049498912 3362 3811116
SGTC_629 3448-6466 76.7 µM -0.48568514157542 0.345450111545741 no 2224 0.313595209981819 3315 573744
SGTC_1498 4478-3555 97.6 µM -0.488869582380495 0.344489155218619 no 2225 0.312467015858907 3335 3437919
SGTC_311 1315-0136 58 µM -0.49004625813385 0.34413432775151 no 2226 0.312050582902891 3409 6759207
SGTC_2143 5623677 140.463 µM -0.491179934988048 0.343792596379987 no 2227 0.311649594581355 3332 5375313
SGTC_2191 5911152 200 µM -0.493033641506269 0.343234096890895 no 2228 0.310994408525637 3304 2875902
SGTC_2254 7938975 95.19 µM -0.493235668961613 0.343173249106705 no 2229 0.310923038770854 3444 2969277
SGTC_2049 5262831 67.185 µM -0.495410054718558 0.342518612826062 no 2230 0.3101553493395 3313 763417
SGTC_1696 st025591 34.7925 µM -0.497654367224701 0.341843419672092 no 2231 0.309363838392178 3301 2787147
SGTC_967 1306-0166 352 µM -0.498479595382835 0.341595279828475 no 2232 0.309073023780774 3384 4437607
SGTC_110 0850-0284 111.64 µM -0.498634665472949 0.341548659065211 no 2233 0.309018389634938 3235 3906265
SGTC_2231 micatex 6.853 µM -0.498741621652584 0.341516504829044 no 2234 0.308980709397594 3334 20737 An antifungal of unknown mechanism.
SGTC_1456 k015-0012 13 µM -0.500227921736736 0.34106979757399 no 2235 0.308457299958088 3441 2989616
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.500950785082401 0.34085262155502 no 2236 0.308202879869161 3290 88881 An O-methylated flavonoid and antioxidant.
SGTC_3263 9137018 49.47 µM -0.502814193432229 0.340293025163405 no 2237 0.307547456836851 3319 43844957
SGTC_407 eburnamonine 100 µM -0.503815190296622 0.339992562872113 no 2238 0.307195626084447 3291 3195
SGTC_953 1188-0045 9.7 µM -0.50543206509853 0.339507451428982 no 2239 0.306627701115419 3381 6144426
SGTC_223 busulfan 5 mM -0.506152080867829 0.339291510364059 no 2240 0.306374945833938 3361 2478 A DNA alkylator.
SGTC_2175 5807670 165.306 µM -0.506260390180162 0.339259031711623 no 2241 0.306336932757142 3365 241186
SGTC_174 3553-0389 74.3 µM -0.506267011747518 0.339257046144687 no 2242 0.30633460886808 3400 738071
SGTC_1365 1672-3266 55.4 µM -0.50726757475834 0.338957065055343 no 2243 0.305983543295526 3392 6415873
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.508490782476338 0.338590471047763 no 2244 0.305554600848089 3373 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3051 9093778 49.47 µM -0.509594153480381 0.338259923105589 no 2245 0.305167910347159 3332 17217378
SGTC_4 0960-0234 25.671 µM -0.510436475859852 0.338007663987503 no 2246 0.304872853969506 3370 6821112
SGTC_2639 lactacystin 53 µM -0.510850670529797 0.337883647430587 no 2247 0.304727812584917 3423 3870 A proteasome inhibitor.
SGTC_555 4296-0685 37 µM -0.511095606688986 0.337810317877055 no 2248 0.304642056049956 3355 2908540 YHR072W ERG7
SGTC_1357 1503-1303 39.5 µM -0.513292613020286 0.337152848567491 no 2249 0.303873325229716 3329 292895
SGTC_3041 9091929 49.47 µM -0.514719430123599 0.336726129791406 no 2250 0.303374546909056 3463 25236887
SGTC_2962 9082311 13.18 µM -0.515623660927862 0.336455809850593 no 2251 0.303058640744031 3267 16459453
SGTC_826 1683-5028 118 µM -0.51585862974278 0.33638557971416 no 2252 0.302976575072138 3376 722377
SGTC_2893 9048488 25.97 µM -0.517563505183921 0.33587617836512 no 2253 0.302381425029414 3322 6467338
SGTC_1452 4194-0072 190 µM -0.517784132000192 0.335810279073173 no 2254 0.302304445384578 3432 1343545
SGTC_1349 flufenamic acid 69 µM -0.520027508275122 0.335140489226814 no 2255 0.301522201187612 3340 3371 A non-steroidal anti-inflammatory.
SGTC_2623 humulene 100 µM -0.520593542313343 0.334971574910423 no 2256 0.301324974424154 3364 6187145 An anti-inflammatory.
SGTC_2746 daunorubicin 9.88 µM -0.521106162864682 0.33481862889843 no 2257 0.301146408995736 3310 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2402 5553605 200 µM -0.521592357625845 0.33467359262663 no 2258 0.300977092753726 3467 6758546
SGTC_903 1134-0042 114 µM -0.521852975497609 0.334595858122686 no 2259 0.30088635083349 3336 701009
SGTC_1310 1188-0297 994 nM -0.523935575119011 0.333974935961154 no 2260 0.300161675068427 3333 1588352
SGTC_438 sphingosine 6.67 µM -0.52618181669906 0.333305733487844 no 2261 0.299380943266775 3245 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1191 1487-1166 10.6 µM -0.52633765680512 0.333259325099058 no 2262 0.299326811709408 3412 3955771
SGTC_778 3456-2434 196 µM -0.527199014712377 0.333002863170027 no 2263 0.299027696411556 3410 5539063
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.52774992749828 0.332838874549851 no 2264 0.298836457534438 3318 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2470 5664817 21.68 µM -0.528140037039617 0.332722771100802 no 2265 0.298701072058761 3420 2859561
SGTC_1913 st060213 96.1 µM -0.52885360418945 0.332510442498887 no 2266 0.298453504489322 3471 688959
SGTC_2734 clemastine 41.6 µM -0.529968230385965 0.332178882543604 no 2267 0.298066978987302 3343 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1971 st069429 63.5 µM -0.531190613153745 0.331815419985728 no 2268 0.297643348542836 3406 1246522 YGL099W LSG1
SGTC_430 0958-0115 16.4 µM -0.531449213406905 0.331738548209697 no 2269 0.297553762952494 3307 6833180
SGTC_3354 9151612 71.43 µM -0.533668733214415 0.33107906310664 no 2270 0.296785372551767 3418 27261949
SGTC_1540 guanosine 70.6 µM -0.534132605056241 0.330941299133376 no 2271 0.29662489648588 3386 6802 Guanosine is a purine nucleoside
SGTC_353 1988-1175 58.3 µM -0.536324197516564 0.330290734137025 no 2272 0.295867254990423 3283 2788357
SGTC_914 3820-6779 408 µM -0.536403048380672 0.33026733713282 no 2273 0.295840012530825 3325 2893481
SGTC_1827 berberine 7.24 µM -0.536604832384912 0.330207465843622 no 2274 0.295770302719987 3295 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1328 1441-0025 69.2 µM -0.536711138818016 0.330175925432683 no 2275 0.295733580340239 3378 4562601
SGTC_1726 st035556 14.5795 µM -0.538717880172267 0.329580765249254 no 2276 0.295040767168547 3484 5919439
SGTC_2305 7443522 69.23 µM -0.539215409559727 0.329433274451099 no 2277 0.294869114414819 3394 5415886
SGTC_773 4358-1457 44.6 µM -0.541608784438479 0.328724138232532 no 2278 0.294044019512721 3456 1186886
SGTC_3313 9133968 57.047 µM -0.542694155661949 0.328402755095406 no 2279 0.293670199410046 3407 1494643
SGTC_2693 st077581 40.7 µM -0.54548301076376 0.327577545519863 no 2280 0.292710681023122 3438 25238761
SGTC_3071 9117417 49.47 µM -0.546076913953686 0.327401920816437 no 2281 0.292506534109599 3319 45595590 YGL055W OLE1
SGTC_970 1315-0089 19.5 µM -0.546168206212695 0.327374927923715 no 2282 0.292475159387534 3412 6811083 YLR033W RSC58
SGTC_2647 atorvastatin 60.16 µM -0.549738195614299 0.326320078135895 no 2283 0.291249477457046 3425 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1979 st071809 45.3 µM -0.550076744731541 0.326220116565843 no 2284 0.291133368209737 3480 4976333
SGTC_1140 3229-1848 2.98 µM -0.550606095597584 0.326063843014358 no 2285 0.290951864681268 3453 2849525
SGTC_2156 5649887 115 µM -0.551318405433412 0.32585360500848 no 2286 0.290707711766037 3465 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_749 1000-0129 128 µM -0.552051089670521 0.325637411263463 no 2287 0.290456675290762 3495 708470
SGTC_2025 5147754 141 µM -0.55466049928433 0.324867927300591 no 2288 0.289563449650663 3424 315777 YLR208W SEC13
SGTC_1262 0737-0114 49.6 µM -0.555602955241675 0.324590191563608 no 2289 0.289241155379918 3505 765919
SGTC_2077 5212015 200 µM -0.556551290990605 0.324310821515327 no 2290 0.288917020682369 3391 780900
SGTC_64 000l-0018 272.079 µM -0.556921351951496 0.324201832136598 no 2291 0.288790582748266 3426 6811119
SGTC_1379 2144-0755 36.5 µM -0.558044973477159 0.323870998418407 no 2292 0.288406837105303 3520 5392327
SGTC_289 k017-0060 526 µM -0.560878998042036 0.32303718015891 no 2293 0.287440014076401 3381 5512909
SGTC_573 3702-0553 84.7 µM -0.560943372884025 0.323018250290054 no 2294 0.287418070516626 3460 1222756
SGTC_2709 st078560 56 µM -0.561385767087252 0.322888173607524 no 2295 0.287267292303324 3513 17250903
SGTC_2708 st078559 56 µM -0.562476829057388 0.32256746247422 no 2296 0.286895593139974 3422 17250902
SGTC_1557 sumaresinolic acid 42.3 µM -0.563256223864386 0.322338444828973 no 2297 0.286630211267671 3407 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1321 1326-2144 215 µM -0.566055357723481 0.321516502680152 no 2298 0.285678074702177 3451 3513030
SGTC_495 decylubiquinone 155 µM -0.566883515003974 0.32127348843237 no 2299 0.285396662438449 3436 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1492 4158-0558 28.5 µM -0.567510467678303 0.321089566481814 no 2300 0.28518370841279 3461 3967268
SGTC_1488 4013-0813 75.9 µM -0.567674671241224 0.321041403206321 no 2301 0.285127946687962 3396 2910057
SGTC_371 0195-0006 7.36 µM -0.568219050532118 0.320881750440886 no 2302 0.284943118649709 3396 3928593
SGTC_257 daunorubicin 18.5 µM -0.569678835531699 0.320453795715423 no 2303 0.284447773693963 3475 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2747 doxorubicin 7.63 µM -0.572245064445463 0.319702051444494 no 2304 0.283577980687937 3391 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2018 5133068 143 µM -0.573393030116332 0.3193660088234 no 2305 0.283189304228999 3457 785362
SGTC_32 0928-0142 34.1 µM -0.573482025633252 0.319339963463267 no 2306 0.283159182941003 3463 2244242
SGTC_784 4579-0127 173 µM -0.574421085466901 0.319065193278214 no 2307 0.28284144389181 3526 1948547
SGTC_2519 cryptotanshinone 88.04 µM -0.575683440851667 0.318695982986251 no 2308 0.282414585007226 3497 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1386 3228-0095 33.8 µM -0.57614598770886 0.318560743548843 no 2309 0.282258254805739 3484 870181
SGTC_1394 3474-0001 65.7 µM -0.577430773894459 0.318185224639302 no 2310 0.28182424523175 3401 5017666 YIL048W NEO1
SGTC_654 1124-0271 80.9 µM -0.578645929891143 0.317830229194209 no 2311 0.281414053373349 3440 5403748
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.579159573424471 0.31768022377474 no 2312 0.281240752927142 3509 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_791 1348-1292 225 µM -0.580258949024124 0.317359260654075 no 2313 0.28087000303855 3514 5437054
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.581104251415423 0.317112567648847 no 2314 0.280585096751305 3475 6312947
SGTC_1950 st077106 7.18 µM -0.583868384277183 0.31630645099386 no 2315 0.279654432710612 3437 13831864
SGTC_2295 7971645 200 µM -0.584346968651476 0.316166967723849 no 2316 0.279493449013801 3432 2978226 YKL099C UTP11
SGTC_1539 benzyladenosine 56 µM -0.585689714956268 0.315775764421165 no 2317 0.279042023463979 3432 92208 A nucleotide analog.
SGTC_2176 5809774 33.9695 µM -0.587796850856281 0.315162275493555 no 2318 0.278334329025486 3472 2870539
SGTC_132 0417-1715 25.805 µM -0.590293083664754 0.314436160927346 no 2319 0.277497087735678 3560 6769098
SGTC_42 0133-0086 60.653 µM -0.590374907221085 0.31441237187814 no 2320 0.277469664805523 3459 162923 Model of phenazepam hydroxylation.
SGTC_3034 9090421 49.47 µM -0.590825034998081 0.314281517335399 no 2321 0.277318829463796 3455 17173761
SGTC_2815 7968870 71.43 µM -0.592184333962683 0.313886503579147 no 2322 0.27686357938145 3502 2977326 YHR190W ERG9
SGTC_528 3492-0019 172 µM -0.593042052625951 0.313637359279038 no 2323 0.276576504700034 3516 2869262
SGTC_3170 9103054 49.47 µM -0.59396490848503 0.313369389270309 no 2324 0.276267791926314 3457 16432970
SGTC_383 2324-0395 7.37 µM -0.597251050063643 0.31241599163704 no 2325 0.275169890187455 3518 3146421
SGTC_2898 9056270 58.44 µM -0.599725774295886 0.311698835413695 no 2326 0.274344504018217 3464 19154699
SGTC_1743 st037606 46.3785 µM -0.600383352491542 0.311508394146373 no 2327 0.274125389961434 3520 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2468 5987765 72.9 µM -0.600540957425053 0.31146275765866 no 2328 0.274072886686502 3462 26772094
SGTC_703 3875-0075 71.8 µM -0.600886793285042 0.311362626695004 no 2329 0.273957695049174 3538 2850814
SGTC_774 k060-0086 136 µM -0.600919147586805 0.311353259764115 no 2330 0.273946919643718 3554 5911235
SGTC_3326 9140064 16.379 µM -0.601064713725847 0.311311118255714 no 2331 0.273898442309012 3484 1868434
SGTC_3333 9141820 12.094 µM -0.601353808641359 0.311227432389067 no 2332 0.273802178711285 3460 1939433
SGTC_700 3453-2283 142 µM -0.606084967503069 0.309859267185435 no 2333 0.272229166323552 3581 565664
SGTC_3349 9149703 23.001 µM -0.60610435093134 0.309853667246009 no 2334 0.272222730984123 3526 4910494
SGTC_622 1348-1566 26.3 µM -0.606217256197647 0.309821049401333 no 2335 0.272185247698294 3517 7340407
SGTC_2451 5856223 45.7 µM -0.606844638749546 0.30963982856668 no 2336 0.271977010449996 3483 2179896
SGTC_927 2425-1185 123 µM -0.607754923431051 0.309376973098149 no 2337 0.271675014888464 3485 730375
SGTC_769 0302-0231 76 µM -0.60904622591776 0.309004261524216 no 2338 0.27124689962735 3559 571869 YER009W NTF2
SGTC_2617 dihydrotanshinone i 20.83 µM -0.609639144386388 0.30883319193519 no 2339 0.271050437612595 3528 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2341 7987486 176.74 µM -0.610020298588447 0.308723242734309 no 2340 0.270924180634149 3545 1258686
SGTC_3107 9121808 49.47 µM -0.610199114902406 0.308671666602932 no 2341 0.270864958009691 3492 662681
SGTC_2323 6148992 148.28 µM -0.610932119931271 0.308460284832689 no 2342 0.270622259777521 3456 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2281 7943571 200 µM -0.615415941884034 0.307168637612731 no 2343 0.269140032987074 3592 1244024
SGTC_1308 1187-1617 41.4 µM -0.6222770183359 0.305196805916148 no 2344 0.266879865047267 3551 2882570
SGTC_2218 6965428 192.983 µM -0.622709126092428 0.305072809006066 no 2345 0.266737842242296 3533 675684
SGTC_216 k038-0035 28.382 µM -0.623025148083561 0.304982138035082 no 2346 0.266633998059597 3513 4444231 YPR107C YTH1
SGTC_2621 lithochol-11-enic acid 100 µM -0.624441760147168 0.304575840105609 no 2347 0.266168753531618 3565 6708711
SGTC_1820 st053765 18.6 µM -0.624586660419515 0.304534294894788 no 2348 0.266121188484097 3543 3690829
SGTC_3150 9097574 49.47 µM -0.625195217489849 0.30435983944954 no 2349 0.26592147019658 3539 17217476
SGTC_990 3985-0011 41.3 µM -0.625871339312389 0.304166067369272 no 2350 0.265699667377538 3501 5399565 YGL099W LSG1
SGTC_2971 9092186 9.93 µM -0.627199315524284 0.303785638188489 no 2351 0.265264295924799 3450 25236400
SGTC_983 1491-0821 12.2 µM -0.627595375673382 0.30367221880662 no 2352 0.26513451941189 3544 46495113
SGTC_1924 st058459 75.1 µM -0.628705498112756 0.30335441484733 no 2353 0.264770938979703 3545 688683
SGTC_2299 7976368 114.88 µM -0.629417305270115 0.303150718146698 no 2354 0.264537945758683 3549 2979718
SGTC_3256 9138902 49.47 µM -0.630670643932767 0.302792201021541 no 2355 0.264127948726054 3568 17228773
SGTC_2867 9039098 71.43 µM -0.631345705955788 0.302599178455789 no 2356 0.263907254010367 3547 6463460
SGTC_852 0418-0143 439 µM -0.633164177117041 0.302079491954698 no 2357 0.26331321818221 3606 5369229
SGTC_2102 5377816 72.7585 µM -0.63326485301739 0.302050732295785 no 2358 0.263280350574479 3593 1379702
SGTC_2256 7954252 200 µM -0.634170060509615 0.301792200747005 no 2359 0.262984922108552 3521 2972920
SGTC_1733 st037357 54.9 µM -0.634676357929908 0.301647643193108 no 2360 0.262819758039134 3548 1272339 YGL099W LSG1
SGTC_400 oxethazaine 37.5 µM -0.635454746168518 0.301425459293112 no 2361 0.262565936163218 3541 4621 A local anesthetic.
SGTC_88 0180-0332 8.668 µM -0.636707500549465 0.301068026624206 no 2362 0.262157693507911 3617 3101745
SGTC_1427 4048-4900 550 nM -0.637544471318475 0.300829330768901 no 2363 0.261885126131934 3582 24132586
SGTC_2594 a-mangostin 100 µM -0.63756279474123 0.300824106063458 no 2364 0.261879160563638 3592 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_989 1501-0895 10.3 µM -0.639852611886085 0.300171514478417 no 2365 0.261134212266419 3574 2830112
SGTC_851 0394-0702 453 µM -0.640174880620943 0.300079720186563 no 2366 0.26102945578371 3595 762646
SGTC_3152 9099253 49.47 µM -0.640252692482152 0.300057558336578 no 2367 0.261004165545048 3595 25236131
SGTC_2233 sulbentine 40.3845 µM -0.640916166481203 0.29986862222266 no 2368 0.260788575877055 3553 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2400 5203494 178.7 µM -0.641249142893945 0.29977382152122 no 2369 0.260680412846199 3566 6777674
SGTC_3032 9089427 49.47 µM -0.641708277869348 0.299643124863351 no 2370 0.260531306732555 3562 17173707
SGTC_626 0214-0009 33 µM -0.642106762735721 0.299529713703026 no 2371 0.260401932613906 3613 3437874
SGTC_1138 3761-0006 1.03 µM -0.642357910482458 0.299458245558851 no 2372 0.260320410715477 3573 12061087
SGTC_38 0929-0051 58.268 µM -0.643005452352682 0.299274012743461 no 2373 0.260110280998345 3575 1379719
SGTC_597 k018-0003 82.8 µM -0.646324405666128 0.298330542138855 no 2374 0.259034642723521 3653 6786234
SGTC_2811 7967822 32.47 µM -0.646358693943757 0.298320802165312 no 2375 0.259023542266252 3583 2232244
SGTC_1753 st043925 64 µM -0.648387529197052 0.297744746431106 no 2376 0.258367167093668 3592 670181
SGTC_55 0767-0285 6.563 µM -0.651994090377358 0.296721975198577 no 2377 0.257202492363928 3577 3116166
SGTC_96 0929-0093 37.281 µM -0.653980880467933 0.296159236857781 no 2378 0.256562061842466 3576 6991579
SGTC_2724 maprotiline 69.64 µM -0.65467550323589 0.295962607520804 no 2379 0.256338350251426 3595 4011 A tricyclic antidepressant.
SGTC_1230 0170-0365 3.77 µM -0.655786928373244 0.295648117193879 no 2380 0.255980614051641 3674 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1852 st056254 31.4 µM -0.655790990397811 0.295646968079799 no 2381 0.255979307079135 3560 442583
SGTC_742 0kpi-0133 140 µM -0.655880142037872 0.295621748314817 no 2382 0.255950623062315 3613 2728852
SGTC_2173 5763948 167 µM -0.656263016667323 0.295513449626828 no 2383 0.255827454468035 3605 2867177
SGTC_1900 st060200 72.8 µM -0.656580061810456 0.295423785067221 no 2384 0.255725486266306 3615 688945
SGTC_1978 st071761 42 µM -0.659669263686187 0.294550773735182 no 2385 0.254733047564336 3548 5147680
SGTC_3111 9122088 49.47 µM -0.660102367594599 0.294428473375527 no 2386 0.254594069725165 3532 16876704
SGTC_2482 5981709 142.65 µM -0.660751049349478 0.294245341766853 no 2387 0.254385989860148 3592 877755
SGTC_154 3389-1638 511.116 µM -0.661684952920095 0.29398178063884 no 2388 0.254086575027118 3532 5238686
SGTC_2089 5281248 129.67 µM -0.663294246397648 0.293527870975393 no 2389 0.253571060388872 3629 2737878
SGTC_269 exalamide 29 µM -0.66334417223045 0.293513794324576 no 2390 0.253555076139226 3585 3316 A derivative of salicylamide.
SGTC_2103 5378138 10 µM -0.663914091022494 0.293353127169621 no 2391 0.253372648512656 3660 244142
SGTC_272 doxorubicin 8.13 µM -0.664124379140702 0.293293854643332 no 2392 0.253305353961131 3636 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3188 9110789 49.47 µM -0.665379486716145 0.292940201228085 no 2393 0.252903900975639 3646 849217
SGTC_969 1313-0238 134 µM -0.666787647500904 0.292543657520901 no 2394 0.25245389201929 3640 5212874
SGTC_2737 bleomycin 30.5 nM -0.666882349392577 0.292516998043983 no 2395 0.252423643084073 3640 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3269 9137823 49.47 µM -0.667291877686365 0.292401724962103 no 2396 0.252292856763759 3561 17682936
SGTC_2716 st080858 38.6235 µM -0.667511083761862 0.292340032019557 no 2397 0.252222866134258 3607 5296050
SGTC_351 caspofungin 25 nM -0.667993083526152 0.292204400211472 no 2398 0.252069003739282 3666 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.668583190830739 0.292038387472274 no 2399 0.251880699050836 3648 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_79 0052-0007 94.094 µM -0.669358576829579 0.291820317727795 no 2400 0.251633384404035 3668 2801472
SGTC_1192 1488-0095 21.4 µM -0.669607121812638 0.291750432936412 no 2401 0.251554136444114 3615 915875
SGTC_350 k064-0020 19.8 µM -0.670012029733535 0.291636599402675 no 2402 0.251425060787919 3631 2790705
SGTC_1304 1165-0502 251 µM -0.670066509804406 0.2916212847627 no 2403 0.251407696422915 3621 767425
SGTC_519 k048-0011 62.8 µM -0.670987146631068 0.291362545534397 no 2404 0.251114358880703 3625 6836379
SGTC_1591 genipin 88.4 µM -0.672388679537348 0.290968859264308 no 2405 0.250668143859911 3624 442424 A DNA cross-linking agent.
SGTC_2026 5148700 152 µM -0.67339283420354 0.290686948242175 no 2406 0.250348703114309 3621 79838
SGTC_2088 5278280 127.392 µM -0.676193673062575 0.289901303666091 no 2407 0.249458844522049 3671 791502
SGTC_1066 ketoconazole 628 nM -0.67947647470576 0.288981736585323 no 2408 0.248418004346933 3667 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_737 1950-0117 57.9 µM -0.679809172975753 0.288888618930953 no 2409 0.248312648855613 3612 5393513
SGTC_2121 5257820 149.641 µM -0.680348792976758 0.288737616772912 no 2410 0.248141818167376 3677 791256
SGTC_608 k048-0125 159 µM -0.681017798479843 0.288550460215802 no 2411 0.247930114210659 3667 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2648 atorvastatin 78.68 µM -0.68115160705165 0.288513033674873 no 2412 0.247887782625977 3659 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2184 6075246 200 µM -0.685023595449922 0.287431022449301 no 2413 0.246664515842855 3681 2267320
SGTC_2801 7907800 81.82 µM -0.686540044546513 0.287007780637799 no 2414 0.246186310693146 3686 6620925
SGTC_1512 0259-0544 12.2 µM -0.68663342261257 0.286981728416975 no 2415 0.246156880613336 3648 18476
SGTC_884 0851-0618 334 µM -0.686999968592398 0.28687947393804 no 2416 0.246041374108515 3654 9642473
SGTC_1766 st045414 44.774 µM -0.687163221715327 0.286833937151929 no 2417 0.245989938906368 3700 253960
SGTC_484 loperamide 105 µM -0.687559979280013 0.286723282405869 no 2418 0.2458649588839 3614 3955 An opioid-receptor agonist.
SGTC_607 4491-0986 66.8 µM -0.688422202482467 0.286482880201217 no 2419 0.24559347310653 3675 698981 YDR232W HEM1
SGTC_1996 st072960 66.8 µM -0.688560365628912 0.286444366904775 no 2420 0.245549985040785 3652 1719405
SGTC_2307 7538926 6.34 µM -0.690054572042668 0.286028010465439 no 2421 0.245079934819572 3667 96582
SGTC_455 paf C-16 10 µM -0.691134953917619 0.285727144338991 no 2422 0.244740368007354 3632 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2423 st077119 87.2 µM -0.691136446952249 0.285726728660986 no 2423 0.244739898918043 3620 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1280 0880-0253 10.1 µM -0.691412507413841 0.285649875199238 no 2424 0.244653173139566 3639 6836607
SGTC_564 3555-0129 330 µM -0.692601537884615 0.285318969211652 no 2425 0.244279822474066 3582 563260
SGTC_1632 st005650 90 µM -0.69336760720244 0.285105869655813 no 2426 0.244039442642438 3671 2759605
SGTC_491 tetrandrine 80.3 µM -0.693381301294223 0.285102061023935 no 2427 0.244035146824903 3644 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2798 7813637 45.45 µM -0.695961152757162 0.284384979926562 no 2428 0.243226579157728 3658 956368
SGTC_3153 9100258 49.47 µM -0.697074517369598 0.284075781765901 no 2429 0.242878080358436 3629 25236848
SGTC_572 0960-0087 17.7 µM -0.698224895842354 0.283756473308435 no 2430 0.242518279698429 3675 6796365
SGTC_2406 ethylparaben 405.7 µM -0.698868449253135 0.283577918357387 no 2431 0.242317123290346 3632 8434 A possible steroid mimic.
SGTC_2685 mycophenolic acid 18.85 µM -0.699290350848388 0.283460890288635 no 2432 0.242185297990571 3653 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_550 4123-0385 25.7 µM -0.699926684560547 0.283284426328171 no 2433 0.241986545844853 3689 5731123
SGTC_2076 5212012 200 µM -0.700451450838979 0.283138941179907 no 2434 0.241822707199253 3583 604802
SGTC_2956 9076196 2.52 µM -0.701130267333832 0.282950800658322 no 2435 0.241610861457619 3718 16423868
SGTC_725 1497-0963 19 µM -0.70285736679318 0.282472389247931 no 2436 0.241072321114449 3706 3549977
SGTC_676 falcarinol 140 µM -0.704112939247977 0.282124836506987 no 2437 0.240681221365362 3713 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_324 1315-0088 19.6 µM -0.706890066620653 0.281356837000272 no 2438 0.239817398722446 3628 6787421
SGTC_411 enrofloxacin 100 µM -0.707262350559332 0.281253960648157 no 2439 0.239701728883068 3745 71188 A bacterial gyrase inhibitor.
SGTC_3251 9135047 49.47 µM -0.70731383874355 0.281239733914879 no 2440 0.239685733732433 3668 17682963
SGTC_187 1488-2104 32.728 µM -0.707575247562546 0.281167509236909 no 2441 0.239604534311748 3725 2852859
SGTC_2155 5570423 76 µM -0.7077390267023 0.281122263240962 no 2442 0.239553668502911 3658 797402
SGTC_645 0845-0943 5.41 µM -0.708317240404681 0.280962552746444 no 2443 0.239374136574092 3694 1885106
SGTC_2035 5154463 94.595 µM -0.708997774323921 0.280774636209885 no 2444 0.239162929004671 3683 2769623
SGTC_2768 sulfasalazine 50.2 µM -0.709633714988383 0.280599088207981 no 2445 0.238965653291457 3714 5384001 An antioxidant and salicylic acid derivative.
SGTC_465 cgp-37157 41 µM -0.709762535255211 0.280563534535257 no 2446 0.238925702682923 3605 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_541 4513-1321 94 µM -0.712031447191391 0.279937685128707 no 2447 0.238222651449848 3688 747515
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.71224569473073 0.279878622770887 no 2448 0.238156322737791 3710 66535 A nucleotide analog.
SGTC_3019 9081971 49.47 µM -0.713687698555646 0.279481257908615 no 2449 0.237710157380626 3717 16451803
SGTC_2886 9058944 51.95 µM -0.715861465748528 0.278882763430929 no 2450 0.23703844718311 3566 4949929
SGTC_360 0957-0399 1.01 µM -0.717279664535858 0.278492632961131 no 2451 0.236600776122788 3711 6752301 YPR165W RHO1
SGTC_2850 9015429 58.44 µM -0.717319517059882 0.278481673823693 no 2452 0.23658848364078 3736 6457570
SGTC_93 0109-0045 59.227 µM -0.717913185415338 0.278318444476361 no 2453 0.236405408681013 3780 88733
SGTC_471 1-acyl-paf 4 µM -0.719593827932681 0.277856604210376 no 2454 0.235887556644164 3665 16759367
SGTC_3299 9121982 43.1275 µM -0.720093095923641 0.277719477569868 no 2455 0.23573383904235 3751 17594604 YPL160W CDC60
SGTC_1279 0874-0590 65.2 µM -0.722818645633098 0.276971473926026 no 2456 0.234895655210117 3746 3523074
SGTC_325 2810-4341 181 µM -0.725221171047851 0.276312940459968 no 2457 0.234158178389699 3716 774970
SGTC_2228 7354201 200 µM -0.725411209613773 0.276260883591634 no 2458 0.234099899104973 3737 753451
SGTC_3255 9139072 49.47 µM -0.725564425409728 0.276218917012203 no 2459 0.234052918139093 3725 17646060
SGTC_3168 9103419 49.47 µM -0.726640511343672 0.275924259825564 no 2460 0.233723102229698 3653 16649256
SGTC_3190 9110366 49.47 µM -0.727821544808375 0.275601043403576 no 2461 0.233361417070647 3659 17123768
SGTC_1202 1988-0068 29.6 µM -0.728780891774889 0.27533863359176 no 2462 0.233067850941459 3678 2850480
SGTC_984 1492-0255 2.91 µM -0.729132106371899 0.275242596752548 no 2463 0.232960428393934 3675 1585198
SGTC_2874 9043904 71.43 µM -0.729449409575662 0.275155846894964 no 2464 0.232863401639878 3705 4463428
SGTC_2338 7999974 200 µM -0.730212411237046 0.2749472993839 no 2465 0.232630178638039 3768 315925
SGTC_478 N-arachidonylglycine 10 µM -0.730382433788448 0.274900838565154 no 2466 0.232578226369355 3658 5283389
SGTC_516 3992-2719 87.3 µM -0.730554708174165 0.274853766350681 no 2467 0.23252559260766 3695 5350887 YDR037W KRS1
SGTC_3289 9119912 71.43 µM -0.733561145807848 0.274032928219099 no 2468 0.231608124302805 3732 17014829
SGTC_3238 9133470 49.47 µM -0.733876093975563 0.27394700906885 no 2469 0.231512129117547 3731 3534688
SGTC_1934 st074720 32.6 µM -0.734229058471027 0.27385073473493 no 2470 0.231404573042003 3698 17250992
SGTC_2634 4'-methoxyflavone 100 µM -0.735259804084388 0.273569685120112 no 2471 0.231090641647692 3744 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3200 9114385 49.47 µM -0.735558822294821 0.273488179643923 no 2472 0.230999614980276 3724 17018030 YLR208W SEC13
SGTC_1653 st012112 65 µM -0.735808035605094 0.273420259021407 no 2473 0.230923765139295 3734 720429
SGTC_2360 9040895 200 µM -0.737530277328916 0.272951107486807 no 2474 0.230399968908456 3743 4914414
SGTC_613 3914-0030 117 µM -0.738470787595108 0.272695074065847 no 2475 0.230114206244096 3503 1145395
SGTC_3060 1327-0027 12.5 µM -0.738706525906954 0.272630918133403 no 2476 0.230042611103314 3683 16000455 YPR107C YTH1
SGTC_2389 9091542 195.52 µM -0.740171757555418 0.272232324959631 no 2477 0.229597891074756 3762 3626624 YOL127W RPL25
SGTC_60 0986-0278 202 µM -0.740203936818584 0.272223574349359 no 2478 0.229588129588334 3578 3110598
SGTC_1640 st009078 66.4 µM -0.742161449868261 0.271691524586099 no 2479 0.228994761103637 3735 690618
SGTC_885 0865-0106 16.8 µM -0.743017474128775 0.271459020978547 no 2480 0.228735550566542 3684 2793380
SGTC_1623 st003709 20.3 µM -0.743354986766475 0.271367376873122 no 2481 0.228633394517909 3734 16192618
SGTC_2663 amphotericin b 100 µM -0.743692263062372 0.271275812344351 no 2482 0.228531335603596 3743 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2483 5729050 27.16 µM -0.74456966151308 0.271037686397506 no 2483 0.228265957071194 3757 2865180
SGTC_2752 diclazuril 33.15 µM -0.744903445421766 0.270947124826936 no 2484 0.228165046065033 3783 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2932 9016711 44.54 µM -0.745119942701658 0.27088839329899 no 2485 0.22809960707641 3741 7117328
SGTC_2370 9071495 200 µM -0.74512152879287 0.270887963046542 no 2486 0.228099127699613 3738 21791103
SGTC_1899 st063254 59.6 µM -0.745369825862137 0.27082061272615 no 2487 0.228024089913979 3683 3093813
SGTC_2114 5491910 81.25 µM -0.746892841632521 0.270407679249618 no 2488 0.22756412364982 3815 2849228
SGTC_118 0083-0097 135.343 µM -0.748044615509275 0.270095609256944 no 2489 0.227216623454611 3803 5207356
SGTC_19 0279-0214 38.434 µM -0.748068541518247 0.270089128480768 no 2490 0.227209407941888 3806 3566274 YBR002C RER2
SGTC_644 1498-1197 63.3 µM -0.748582915083693 0.269949820259981 no 2491 0.227054316398261 3814 6741615
SGTC_3260 9137109 49.47 µM -0.750808068900286 0.269347594580999 no 2492 0.226384086333053 3619 17478346
SGTC_1245 0418-0076 17.2 µM -0.752368607564775 0.268925645612137 no 2493 0.225914709820051 3780 6790114
SGTC_2428 5615643 7.78 µM -0.752406335802096 0.268915448507099 no 2494 0.225903368793402 3790 2253075
SGTC_479 n-linoleoylglycine 10 µM -0.754054082093139 0.268470288735931 no 2495 0.2254083739758 3790 6433346 An anti-infammatory.
SGTC_1244 0416-0015 52.5 µM -0.754180685632209 0.268436100501201 no 2496 0.225370366783372 3758 96201
SGTC_581 0958-0271 211 µM -0.759285922028511 0.26705930037166 no 2497 0.223840768542133 3790 4591145
SGTC_1703 st026983 48.3 µM -0.759858887582754 0.266905003617939 no 2498 0.223669469306685 3773 1104023
SGTC_1450 4112-4260 37.6 µM -0.760353692696305 0.266771791327721 no 2499 0.223521597659109 3742 1633175
SGTC_3201 9113999 49.47 µM -0.761044012581231 0.266585998367837 no 2500 0.223315389698368 3808 16649224
SGTC_797 k781-0471 270 µM -0.76274131829528 0.266129463236936 no 2501 0.222808841946012 3758 23738129
SGTC_2762 leflunomide 42.06 µM -0.763170758947328 0.266014016634887 no 2502 0.222680782566619 3751 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_443 clozapine 122 µM -0.763683214226004 0.265876286402294 no 2503 0.222528023106772 3675 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2066 5222451 176 µM -0.76443733329522 0.265673671049527 no 2504 0.222303334004672 3775 2281147
SGTC_1638 st008370 60.6 µM -0.764643974021785 0.265618164860724 no 2505 0.222241788185453 3773 24207134
SGTC_2355 9061122 103.12 µM -0.765712177256233 0.265331326414333 no 2506 0.221923789897423 3807 5302957
SGTC_1558 st069300 45.6 µM -0.766169335942891 0.265208616292437 no 2507 0.221787775681641 3714 24208000
SGTC_1113 artemisinin 1.17947 µM -0.767183223583414 0.264936572349517 no 2508 0.221486293004174 3783 2240 An anti-malaria and mitochondrial poison.
SGTC_793 0488-0545 106 µM -0.767405942742207 0.264876831872574 no 2509 0.221420098159993 3786 292548
SGTC_1043 0916-0009 19.3 µM -0.76772870968583 0.264790267499086 no 2510 0.221324187974009 3795 3101130
SGTC_618 k072-0232 33.2 µM -0.768432132335221 0.264601663136985 no 2511 0.22111524829123 3801 5872756 YGL099W LSG1
SGTC_1656 st012921 11 µM -0.768752310733996 0.264515838321806 no 2512 0.221020182156907 3721 6732821
SGTC_1526 st051518 75 µM -0.770957849879108 0.263925021797455 no 2513 0.220365957875794 3791 673993
SGTC_601 0986-0029 62.9 µM -0.771644984511002 0.263741090725286 no 2514 0.220162361646467 3766 24747981
SGTC_2740 felodipine 17.08 µM -0.773397525764297 0.263272269539706 no 2515 0.219643576911286 3711 3333 L-type calcium channel blocker
SGTC_3198 9112019 49.47 µM -0.77414865816801 0.263071464973995 no 2516 0.219421442868082 3827 45595555
SGTC_2905 7799065 20.05 µM -0.774627615251427 0.262943463487304 no 2517 0.219279867251519 3702 1296806
SGTC_1612 st002233 45.4 µM -0.776896439089746 0.262337552281744 no 2518 0.218609936156869 3804 1035021
SGTC_499 genistein 192 µM -0.779045347863673 0.261764325644539 no 2519 0.217976501099456 3804 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1122 capsaicin 818.572 nM -0.780203090315593 0.261455761600594 no 2520 0.21763567181865 3897 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2477 5967686 25.23 µM -0.782856557761654 0.260749258914062 no 2521 0.216855675302209 3817 776118
SGTC_1758 st042942 75.2445 µM -0.784417604517134 0.260334079651881 no 2522 0.216397555941771 3738 669317
SGTC_486 niguldipine 82 µM -0.784595063579642 0.260286903835926 no 2523 0.216345512628428 3831 1236 A calcium channel blocker.
SGTC_1755 st041960 45.185 µM -0.785799381058722 0.259966863826939 no 2524 0.215992514631425 3850 2257073
SGTC_3298 9116858 71.43 µM -0.788669649523959 0.25920492658274 no 2525 0.215152555622705 3866 2506942
SGTC_1813 st051246 8.6015 µM -0.790269820288303 0.258780649294483 no 2526 0.214685104017223 3733 5291959
SGTC_1356 1502-0781 85.8 µM -0.791914302041502 0.258344997941998 no 2527 0.214205323535319 3785 567702
SGTC_2105 5350118 200 µM -0.792862600402219 0.258093950354628 no 2528 0.213928939618187 3830 2133313
SGTC_63 0099-0242 26.702 µM -0.793381180853981 0.257956717581715 no 2529 0.213777885907408 3867 3898502 YLR359W ADE13
SGTC_2879 9041815 71.43 µM -0.794121537788589 0.257760861362323 no 2530 0.213562340140572 3809 4942971
SGTC_415 dibenzyl ketone 100 µM -0.794142659466748 0.257755274903599 no 2531 0.213556192683662 3844 7593
SGTC_281 1672-3440 14.9 µM -0.794407239884616 0.257685301528067 no 2532 0.213479195383356 3871 6833000
SGTC_1125 tnp00248 1.32998 µM -0.794463943803921 0.257670306370414 no 2533 0.213462695705715 3929 24207736
SGTC_1840 st055363 71 µM -0.796596753629812 0.257106621268336 no 2534 0.212842631713602 3849 676033
SGTC_1772 st048439 82.2 µM -0.799163276783246 0.256429160224332 no 2535 0.212097871346984 3871 2927068 YDL195W SEC31
SGTC_855 0428-0020 25 µM -0.799903785894503 0.256233868020774 no 2536 0.211883272069688 3840 6812414
SGTC_636 0kpi-0074 126 µM -0.800195968659044 0.256156832892939 no 2537 0.211798632568489 3856 616434
SGTC_558 k064-0027 21.3 µM -0.800250073582639 0.256142569243747 no 2538 0.211782961625762 3878 5088526
SGTC_2044 5102272 200 µM -0.800341720284098 0.256118409422751 no 2539 0.211756418635611 3841 592666
SGTC_497 capsazepine 133 µM -0.800416830018602 0.256098609948267 no 2540 0.211734666582574 3821 2733484 A calcium channel blocker.
SGTC_1550 gossypolone 36.6 µM -0.801623809201536 0.255780550941892 no 2541 0.211385300387091 3832 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3023 9089636 49.47 µM -0.802084722771962 0.255659147012268 no 2542 0.211251975771357 3915 17249241
SGTC_2556 citropten 84.59 µM -0.804396662791723 0.255050639871367 no 2543 0.210583963950715 3877 2775 A potential DNA crosslinker.
SGTC_3116 9124943 49.47 µM -0.804544094333746 0.255011861315175 no 2544 0.21054140717355 3811 41905195 YPL160W CDC60
SGTC_1485 3909-9022 254 µM -0.804553026431206 0.255009512026637 no 2545 0.210538829045641 3867 714516
SGTC_1952 st077036 64.1 µM -0.805022103788021 0.254886152880122 no 2546 0.210403462311316 3833 2937007
SGTC_663 1486-0733 13.9 µM -0.809223963332603 0.253782531691797 no 2547 0.20919316675555 3862 722445 YPR165W RHO1
SGTC_1322 1348-1070 12 µM -0.810419302613703 0.253469034030259 no 2548 0.208849613805295 3795 6758089
SGTC_1991 st073000 8.92 µM -0.810607713746076 0.253419638641096 no 2549 0.208795492829019 3925 4301969 YIL048W NEO1
SGTC_1737 st035557 69.7 µM -0.811337359689763 0.25322839649 no 2550 0.208585980489101 3745 5716916
SGTC_86 0417-1630 471.922 µM -0.811754549387683 0.253119084065931 no 2551 0.208466243320907 3873 3634867
SGTC_911 3456-4043 236 µM -0.812734995109009 0.252862284528053 no 2552 0.208185006257949 3921 914281
SGTC_3094 9117742 49.47 µM -0.814967741430149 0.252277993043386 no 2553 0.207545387688961 3783 17149698
SGTC_2687 chenodiol 100 µM -0.815374526462439 0.252171617435012 no 2554 0.207428980494044 3897 5702181 A cholesterol synthesis inhibitor.
SGTC_2426 5582046 32.21 µM -0.815654864722593 0.252098321840275 no 2555 0.207348780270488 3843 2251934
SGTC_2996 9066192 71.4286 µM -0.815822408870125 0.252054522097596 no 2556 0.207300857364785 3909 6472854
SGTC_1878 temozolomide 1 mM -0.817865721129117 0.251520678334593 no 2557 0.206716932848145 3768 5394 DNA alkylating agent.
SGTC_2526 patulin 37.61 µM -0.817984436859441 0.251489680571616 no 2558 0.206683036998969 3932 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_718 1130-0073 349 µM -0.818094340854578 0.251460985432887 no 2559 0.206651660020351 3910 6740020
SGTC_1779 st039427 55 µM -0.819736418236523 0.251032457033456 no 2560 0.206183192090783 3846 1124498
SGTC_2754 granisetron 64.02 µM -0.820907713432652 0.250727023630719 no 2561 0.205849418556144 3853 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2070 5230947 200 µM -0.8215207416293 0.250567245500842 no 2562 0.205674857252431 3913 2835538
SGTC_1819 st053448 58.6 µM -0.821639339990646 0.250536340550459 no 2563 0.205641096219867 3788 2857616
SGTC_1128 3448-9350 235 µM -0.822849848747569 0.250221015706497 no 2564 0.205296692569735 3925 619386
SGTC_3069 9117009 49.47 µM -0.823308613686345 0.250101567266608 no 2565 0.205166258261289 3812 41904981
SGTC_90 0870-0863 4.608 µM -0.823931376757264 0.249939467113976 no 2566 0.204989275442958 3854 1738164
SGTC_2524 avocatin b 10.57 µM -0.825265716709558 0.249592337108936 no 2567 0.204610375528512 3840 6710748
SGTC_3029 9088683 49.47 µM -0.826480005032171 0.249276661394299 no 2568 0.204265927954976 3869 25236615
SGTC_2275 7947463 200 µM -0.830431796387395 0.248250794728203 no 2569 0.20314734724692 3805 1225414
SGTC_2337 9009472 200 µM -0.832067350358197 0.247826872109672 no 2570 0.202685464829129 3836 5742383
SGTC_2846 9008642 19.48 µM -0.832086394608097 0.247821938268245 no 2571 0.202680090408816 3950 2992898
SGTC_2203 7227154 166.4 µM -0.833666184631134 0.24741284077375 no 2572 0.202234559244332 3867 896304
SGTC_3309 9129340 25.759 µM -0.834697273930606 0.247146027892511 no 2573 0.201944088469199 3915 17158987
SGTC_2142 5622915 118.518 µM -0.83640138095426 0.24670539715031 no 2574 0.201464567989614 3900 5322196
SGTC_841 0251-0215 91.2 µM -0.838117198525963 0.246262163788367 no 2575 0.200982442305642 3920 3888614
SGTC_2894 9048625 32.47 µM -0.838169479436048 0.24624866518692 no 2576 0.200967762825132 3891 4092861
SGTC_3215 9129942 49.47 µM -0.83855519253256 0.246149088757827 no 2577 0.200859481837958 3842 17682944
SGTC_165 k038-0023 64.381 µM -0.838967227766257 0.246042740815984 no 2578 0.200743850137363 3902 46368543
SGTC_205 1486-1330 71.903 µM -0.839481179418001 0.245910122395092 no 2579 0.200599673091452 3881 4118834
SGTC_2861 9024595 19.48 µM -0.839830952741055 0.245819889960776 no 2580 0.200501587977947 3783 16482810
SGTC_1362 1611-0397 101 µM -0.841110129004561 0.245490047110025 no 2581 0.200143120590171 3851 27816
SGTC_2443 5493264 126.67 µM -0.843196327393267 0.244952619574315 no 2582 0.199559326041877 3916 5340055
SGTC_2968 9090663 33.37 µM -0.843856797590446 0.244782607251955 no 2583 0.199374716145205 3881 25236811
SGTC_357 1325-0123 420 µM -0.84692518466789 0.243993604244735 no 2584 0.198518411924084 3936 1098503
SGTC_2430 5571206 200 µM -0.847487355578926 0.243849196843306 no 2585 0.198361765976656 3925 1731771
SGTC_997 3996-0078 137 µM -0.847801685941776 0.243768473481406 no 2586 0.19827421200758 3936 735687
SGTC_1687 st020778 55.3625 µM -0.84843267076216 0.243606473455879 no 2587 0.198098527134937 3902 4259299
SGTC_1854 st056233 32.9 µM -0.849624321312142 0.243300685885408 no 2588 0.197766992793408 3800 5393174
SGTC_3343 9148379 18.9835 µM -0.850254532059511 0.243139052406063 no 2589 0.197591794711441 3958 1955036
SGTC_822 1487-0950 154 µM -0.85071094435508 0.243022030194533 no 2590 0.197464971056425 3903 1958375
SGTC_3119 9125183 49.47 µM -0.852060530756354 0.242676180155043 no 2591 0.197090248439554 3724 22695334
SGTC_1767 st044992 70.3 µM -0.852515740341819 0.242559586575233 no 2592 0.196963953258771 3962 9600693
SGTC_274 sirtinol 40.1 µM -0.852673320550075 0.242519232366953 no 2593 0.196920244988412 3964 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_662 k832-1615 104 µM -0.854919550401462 0.241944398131505 no 2594 0.196297843290189 3955 5878478
SGTC_1172 0370-0043 85 µM -0.855136740691643 0.241888856027821 no 2595 0.196237725922239 3960 376585
SGTC_1306 1185-0270 9.02 µM -0.855337453020739 0.241837533986365 no 2596 0.196182179511279 3938 1548076
SGTC_2012 4023501 200 µM -0.858007808372098 0.241155288027281 no 2597 0.195444075890302 3942 3477460
SGTC_2614 arthonioic acid 13.39 µM -0.858396291574862 0.241056122158894 no 2598 0.195336837316024 3833 6710684
SGTC_2946 9065502 71.43 µM -0.858778261581566 0.240958640499009 no 2599 0.195231431533371 3762 16489101
SGTC_1770 st043884 66.3 µM -0.858812518655899 0.240949898880083 no 2600 0.195221979878933 3902 670149
SGTC_287 k060-0039 29.6 µM -0.85882515847171 0.240946673532825 no 2601 0.195218492576886 3950 5861974
SGTC_3330 9141424 71.43 µM -0.860747373443304 0.240456448459853 no 2602 0.194688597697431 3994 27261020
SGTC_69 0096-0274 206.684 µM -0.86120555783813 0.240339677299044 no 2603 0.194562419781872 4060 6741392
SGTC_1973 st070275 50.2 µM -0.861362885857227 0.240299588394951 no 2604 0.194519105209164 3817 17118334
SGTC_2934 9036370 36.88 µM -0.861856698083 0.240173783293459 no 2605 0.194383190019945 3939 6462800
SGTC_3203 9113543 49.47 µM -0.862743925106711 0.239947840860252 no 2606 0.194139137990055 4024 17018012
SGTC_1286 0929-0070 131 µM -0.863081510594759 0.239861901337387 no 2607 0.194046326442916 4025 1420408
SGTC_1123 mangostin 811.285 nM -0.863960216179737 0.239638287003356 no 2608 0.193804872868469 3946 5281650 An antioxidant.
SGTC_1645 Cervolide 78 µM -0.864561615662746 0.239485307558583 no 2609 0.193639723982128 3908 23173 A fragrance.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.864694915812193 0.23945140689728 no 2610 0.193603130366238 3931 616764
SGTC_977 1348-1378 135 µM -0.864887664213205 0.239402392094927 no 2611 0.19355022444869 3914 X977
SGTC_94 0334-0113 514.748 µM -0.866778673912221 0.238921809985228 no 2612 0.19303164456181 3943 6795178
SGTC_1148 3909-7663 27.7 µM -0.866856456137803 0.238902053675727 no 2613 0.193010332183114 3979 4084526
SGTC_2227 7312221 64.1025 µM -0.868013928590255 0.238608166854754 no 2614 0.192693353814734 3972 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3082 9117008 49.47 µM -0.868643334123057 0.238448441394685 no 2615 0.192521122240707 3996 41448529
SGTC_3165 9101544 49.47 µM -0.868755983905235 0.23841986021924 no 2616 0.192490306499082 3936 5002184
SGTC_1022 4477-0945 21.3 µM -0.868920146677876 0.238378212676445 no 2617 0.192445404598351 3874 4648966
SGTC_2188 6126565 140.678 µM -0.869122661142177 0.238326840927914 no 2618 0.192390021543448 3855 874518
SGTC_734 2023-0417 80 µM -0.870131282013961 0.238071074873729 no 2619 0.192114332073104 3950 3935732
SGTC_2442 5158906 48.48 µM -0.871338521082439 0.237765141113643 no 2620 0.191784671655346 3965 1893835
SGTC_142 0335-0849 62.6745 µM -0.872890609796909 0.23737213396064 no 2621 0.191361352501389 3937 3889043 YPR107C YTH1
SGTC_945 3381-0768 11.3 µM -0.875003975482118 0.236837578845149 no 2622 0.190785871304611 3997 1126236 YIL048W NEO1
SGTC_379 3970-0972 5.9 µM -0.875099566031802 0.236813415810202 no 2623 0.190759866595833 3928 2898042 YBL034C STU1
SGTC_1247 0448-0043 5.84 µM -0.87512435371664 0.236807150289826 no 2624 0.190753123642922 3988 3089013 YGL099W LSG1
SGTC_536 3852-0578 10.6 µM -0.875130062446966 0.236805707321421 no 2625 0.190751570727175 3994 2869208
SGTC_1330 1469-0054 61.8 µM -0.875630686301176 0.236679185834332 no 2626 0.19061541883816 3950 7102664
SGTC_70 0141-0289 43.283 µM -0.8762771189273 0.236515869461458 no 2627 0.190439700419036 3953 352408
SGTC_1011 4112-3381 17.4 µM -0.876910693980251 0.236355861655886 no 2628 0.190267573605916 4026 2877139
SGTC_34 0469-0683 81.75 µM -0.877168776382713 0.236290700672602 no 2629 0.190197486345651 3910 3690923
SGTC_346 4513-0042 7.16 µM -0.877950017283461 0.236093512251875 no 2630 0.189985421995428 3934 2827372
SGTC_1030 k029-0042 36.7 µM -0.880163023074411 0.235535432917238 no 2631 0.189385500866721 3932 6080581
SGTC_921 1561-0023 372 µM -0.880423752598377 0.235469729690219 no 2632 0.189314896866364 3914 24050882
SGTC_702 1488-0190 94 µM -0.881594000501432 0.235174954576757 no 2633 0.188998200328351 3988 949357
SGTC_293 4049-0273 38.5 µM -0.881797777252894 0.235123645852938 no 2634 0.18894308693913 3823 1380311
SGTC_3068 9116768 49.47 µM -0.882558024121842 0.234932278703078 no 2635 0.188737558226435 3908 41904888
SGTC_2379 9035213 200 µM -0.882760403385779 0.23488135088744 no 2636 0.188682869296899 3900 646551
SGTC_1655 st012546 55.1 µM -0.884110010740372 0.234541884434075 no 2637 0.188318414857709 3931 720985 YLR208W SEC13
SGTC_3264 9137442 49.47 µM -0.887162423171151 0.233775113747101 no 2638 0.187495730050881 3917 17015726
SGTC_614 0462-0418 107 µM -0.888230747206058 0.233507077704825 no 2639 0.187208321357945 3754 5188303
SGTC_2986 9022445 71.43 µM -0.888333772377721 0.233481238326478 no 2640 0.187180619149877 3966 6459286
SGTC_595 3909-8003 73.7 µM -0.888653566897591 0.233401041898774 no 2641 0.187094646464876 4023 699517
SGTC_1837 st055472 66.5 µM -0.891824377002741 0.232606709922928 no 2642 0.186243536742104 4056 676091
SGTC_341 1486-1430 230 µM -0.892858858831908 0.232347883363166 no 2643 0.185966380718877 3936 2054753 YPL210C SRP72
SGTC_711 k292-0785 179 µM -0.892861246440132 0.232347286170795 no 2644 0.185965741332244 3929 4146315
SGTC_1610 st001799 48.1 µM -0.895528345461847 0.231680720583497 no 2645 0.185252360151552 3870 621897
SGTC_2381 9035592 200 µM -0.8970478665256 0.231301436494298 no 2646 0.184846687832434 3963 4749657
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.898654501993202 0.230900784960561 no 2647 0.184418359269667 3971 77254
SGTC_40 0327-0103 19.753 µM -0.901396336418931 0.230217941213689 no 2648 0.183688814305161 3854 409036
SGTC_26 0302-0163 425.158 µM -0.903111683535736 0.229791315359188 no 2649 0.183233311882974 4022 3100915
SGTC_2348 9022543 33.42 µM -0.907451261797985 0.228713993193134 no 2650 0.182084105937591 4030 3162678 YDL140C RPO21
SGTC_2211 7117706 200 µM -0.907545184828818 0.22869070772325 no 2651 0.182059283187378 3912 822771
SGTC_3137 9097352 49.47 µM -0.908832978772545 0.228371571145121 no 2652 0.181719147825066 3998 44120435
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.909656699223294 0.228167570940512 no 2653 0.181501793341222 3977 75037 A free radical scavenger.
SGTC_2390 9097792 176.6 µM -0.90966921186483 0.228164472886416 no 2654 0.181498492895335 3980 4497149
SGTC_2278 7948257 134.34 µM -0.910983165243586 0.227839277678289 no 2655 0.18115212195326 3984 1247028
SGTC_2404 5161160 200 µM -0.912792679692472 0.227391861428255 no 2656 0.180675794530727 3949 2831543
SGTC_1874 staurosporine 7.6 µM -0.913535723289499 0.227208281682358 no 2657 0.180480427157078 4031 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1375 2910-0797 186 µM -0.917627318769705 0.22619889114293 no 2658 0.179407005260186 4014 742508
SGTC_2421 5690543 90.72 µM -0.91891965726837 0.225880600475566 no 2659 0.179068798642927 4025 3397993
SGTC_1235 benzylparaben 21.5 µM -0.922340997266619 0.225039180954761 no 2660 0.178175367865252 4005 7180
SGTC_290 2043-6722 48.1 µM -0.92297170644811 0.224884263038541 no 2661 0.178010975019606 4014 773758 YLR208W SEC13
SGTC_2326 6164455 177.58 µM -0.923062478568646 0.224861972117918 no 2662 0.177987323357635 3999 2888790
SGTC_1783 st039459 87.517 µM -0.923107785327601 0.224850846600295 no 2663 0.177975518930854 4111 729761
SGTC_770 0389-1121 67.2 µM -0.923150685210139 0.224840312402361 no 2664 0.177964342057525 4122 6753108
SGTC_2013 4024628 200 µM -0.92321276514498 0.224825068979095 no 2665 0.177948168914247 4055 5230760
SGTC_2264 7948757 110.76 µM -0.924039355525361 0.224622159617787 no 2666 0.177732912879827 3952 2971411
SGTC_1946 st076057 65.1 µM -0.924679331432571 0.224465131291695 no 2667 0.17756636682162 3914 953009
SGTC_1569 carminic acid 40.6 µM -0.925249450115504 0.224325296034788 no 2668 0.177418083251101 4092 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_285 1486-1325 46 µM -0.92531590209769 0.224309000313721 no 2669 0.177400804680055 4042 22310230
SGTC_1870 st057514 26.5 µM -0.925853620397933 0.224177162793582 no 2670 0.177261028461133 3981 5393161
SGTC_2347 9049783 174.81 µM -0.926480884529962 0.224023426089514 no 2671 0.177098063324894 4050 6467988 YPL169C MEX67
SGTC_368 fentichlor 4.58 µM -0.92648321236793 0.224022855669282 no 2672 0.177097458721812 4068 7329 A pesticide.
SGTC_3186 9110464 49.47 µM -0.926585694201798 0.22399774403846 no 2673 0.177070842683651 4020 17018021
SGTC_2704 st078022 71.1 µM -0.926684295674302 0.223973584741405 no 2674 0.177045236817918 4054 54697681
SGTC_2670 beta-carotene 100 µM -0.929658781252667 0.223245473677584 no 2675 0.176273891156698 3932 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1447 4239-0816 81.9 µM -0.930669984737958 0.22299825289047 no 2676 0.176012150267618 4020 1341554
SGTC_1590 st077108 57.8 µM -0.930875085593017 0.222948128503713 no 2677 0.175959091795947 4017 5489485
SGTC_2306 7482397 179.52 µM -0.931056722854123 0.222903743719416 no 2678 0.175912111685196 4028 891448
SGTC_1629 st005085 44.9 µM -0.931164941041513 0.222877301973969 no 2679 0.175884125046166 3974 24207091
SGTC_3250 9135583 49.47 µM -0.93119189889888 0.222870715440489 no 2680 0.175877153830314 4031 7699353
SGTC_426 0988-0037 14.6 µM -0.93131304138092 0.222841118425415 no 2681 0.175845828931346 4039 5383008
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.933179745205704 0.222385336512428 no 2682 0.175363585383282 4048 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1139 k015-0024 46.9 µM -0.933482200845067 0.222311537817667 no 2683 0.175285528117526 4040 2766652
SGTC_3312 9133330 71.43 µM -0.933574796317329 0.222288947463541 no 2684 0.175261635632326 4065 17617324
SGTC_365 0121-0052 13.6 µM -0.934302116659697 0.22211154995471 no 2685 0.175074036397051 4057 3101739
SGTC_939 1165-0479 45.3 µM -0.934326980102042 0.222105487050502 no 2686 0.175067625570724 4001 1377347
SGTC_2834 9001755 58.44 µM -0.937049344960199 0.221442215100819 no 2687 0.174366588005044 3939 2989575
SGTC_3124 9127567 49.47 µM -0.93820488495875 0.221161024180088 no 2688 0.174069564225433 4025 17592030
SGTC_3064 1327-0027 10 µM -0.938472045944743 0.22109604189243 no 2689 0.174000938096595 3910 16000455 YPR107C YTH1
SGTC_3274 9138298 49.47 µM -0.93881369407867 0.221012957816183 no 2690 0.173913203386189 3977 17015756
SGTC_2943 9068529 45.32 µM -0.939077140469291 0.220948903520401 no 2691 0.173845569974664 4000 3270634
SGTC_236 1509-0011 5.31 µM -0.93984246473358 0.220762883039548 no 2692 0.173649186603824 4074 3107280
SGTC_2147 5545932 89.7195 µM -0.942289814025793 0.220168630217168 no 2693 0.173022140859643 4048 797404
SGTC_2924 9010168 62.78 µM -0.943799917887099 0.219802412671726 no 2694 0.172635951292136 4124 2993929
SGTC_3345 9148410 3.559 µM -0.944231146182616 0.219697899070886 no 2695 0.172525771176515 4005 4903596
SGTC_1320 1313-0481 95.3 µM -0.946273763667867 0.219203232875719 no 2696 0.17200448577264 4022 6813365 YLR208W SEC13
SGTC_2551 apiole 73.87 µM -0.947675189784959 0.218864216382904 no 2697 0.171647417579495 3880 10659 A possible DNA adduct former.
SGTC_2074 5212007 75.395 µM -0.947931231174237 0.218802310474242 no 2698 0.171582232205932 3871 758611
SGTC_3100 9120536 49.47 µM -0.94846213780059 0.218673979521854 no 2699 0.171447119518733 3859 16421196
SGTC_194 1486-1323 56.904 µM -0.948830584609045 0.218584943890888 no 2700 0.171353391903827 4079 5178754
SGTC_964 1287-0107 19.4 µM -0.949602111332114 0.218398571120834 no 2701 0.171157232632957 4054 51516812 YPR165W RHO1
SGTC_2021 4019055 173 µM -0.950023612140689 0.218296790542396 no 2702 0.171050127497579 3915 44827708 YER133W GLC7
SGTC_3125 9127534 49.47 µM -0.952752049694343 0.217638611004618 no 2703 0.170357857233339 3918 1639235
SGTC_1972 st070201 17.4 µM -0.955519816014868 0.216972115698085 no 2704 0.169657444598014 4026 2829099
SGTC_2742 clothiapine 36.27 µM -0.956000160575558 0.216856565996509 no 2705 0.169536076680901 3993 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_715 0868-0130 184 µM -0.956553870384688 0.216723412005977 no 2706 0.169396240816202 4085 2876258
SGTC_1047 2043-3044 82 µM -0.956854707811811 0.216651087614149 no 2707 0.169320297294563 4034 669592
SGTC_996 3970-0799 1.8 µM -0.956899894617753 0.216640225450293 no 2708 0.169308892207125 4058 6615648 YGL040C HEM2
SGTC_3271 9137798 49.47 µM -0.958882283324896 0.216164001996746 no 2709 0.168809025439367 3968 6498326
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.960158195634765 0.215857814224331 no 2710 0.168487801453431 4154 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3054 9094397 49.47 µM -0.96114399465323 0.215621418759656 no 2711 0.168239885770799 4055 2598354
SGTC_2568 diosmetin 100 µM -0.961741340800226 0.215478247702376 no 2712 0.168089775191161 4108 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_322 k048-0136 19.3 µM -0.961787572630592 0.215467169223862 no 2713 0.168078160920615 4118 6823282
SGTC_2983 9022671 12.99 µM -0.963226389676292 0.215122552384129 no 2714 0.167716962237751 4067 6405161
SGTC_1301 naphtanilide LB 4.81 µM -0.970712076463848 0.213334795959904 no 2715 0.165845838209164 4130 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2792 7535235 81.82 µM -0.970771981060492 0.213320524370542 no 2716 0.16583091907346 4061 1281891
SGTC_280 3448-3607 3.04 µM -0.972262761654873 0.212965542164987 no 2717 0.165459922209077 4032 626179
SGTC_1418 3966-3099 2.4 µM -0.974053043717595 0.212539699026073 no 2718 0.165015101290368 4056 740335
SGTC_1923 st058458 19.1 µM -0.974450559123108 0.212445212059481 no 2719 0.164916438106191 4096 3534982
SGTC_2976 9009005 19.48 µM -0.979038909141554 0.211356367181783 no 2720 0.163780377380047 4091 2993148
SGTC_2677 mitomycin C 100 µM -0.979364241850221 0.21127928794641 no 2721 0.163700019353535 4088 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_504 lovastatin 124 µM -0.980014013904854 0.211125390435555 no 2722 0.163539600586725 4083 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2075 5212009 200 µM -0.980567237359316 0.210994412106604 no 2723 0.163403098676666 3968 780898
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.98146696484629 0.210781499035328 no 2724 0.163181258740309 4118 61125 An anti-inflammatory.
SGTC_78 0336-0123 156.75 µM -0.981618178988411 0.21074572783205 no 2725 0.163143994075688 3895 6765896
SGTC_706 4262-0057 46.9 µM -0.98177441907461 0.21070877143259 no 2726 0.163105496645402 4057 883298
SGTC_1621 st003705 32.4 µM -0.983745044626832 0.210242974084771 no 2727 0.162620443032682 4083 24207032
SGTC_1167 k781-0610 148 µM -0.985254031706163 0.209886703527206 no 2728 0.162249653097472 4104 4525169
SGTC_1114 scopoletin 1.73284 µM -0.985712542091928 0.20977851994931 no 2729 0.162137096548237 4111 5280460 A coumarin with genotoxic properties.
SGTC_1453 4237-0541 195 µM -0.988546667239099 0.209110548099729 no 2730 0.161442495528427 4068 739892
SGTC_2407 paclitaxel 400 µM -0.989141156168087 0.20897059272739 no 2731 0.161297041887151 4200 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2474 5321570 43.32 µM -0.98938062283136 0.208914232759918 no 2732 0.161238475722948 4083 2841384
SGTC_2118 5526350 200 µM -0.99112238988517 0.208504566566636 no 2733 0.160812910651167 4112 743594
SGTC_3042 9091578 49.47 µM -0.99400395989118 0.207827858082637 no 2734 0.160110469800611 4061 25236497
SGTC_252 miconazole 1.30953 nM -0.994853528077241 0.207628593173511 no 2735 0.15990375389643 3988 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_186 3455-3465 67.277 µM -0.995063009487069 0.207579476986204 no 2736 0.15985280997296 4027 755278
SGTC_3261 9137475 49.47 µM -0.995687910143069 0.207433000065871 no 2737 0.159700903047568 4012 17027690
SGTC_3016 9080866 49.47 µM -0.996002695961281 0.207359237312779 no 2738 0.159624417637978 4068 17066299
SGTC_1146 3579-1023 7 µM -0.996139064782143 0.207327287258403 no 2739 0.159591290726069 4120 X1146
SGTC_2620 irigenin 100 µM -0.996295852378189 0.207290556856112 no 2740 0.159553209216455 4140 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1209 2323-2347 50.3 µM -0.999102763206176 0.206633637243874 no 2741 0.158872456365825 4101 5412760
SGTC_1740 st038286 13.222 µM -1.00076889035067 0.206244286454525 no 2742 0.158469276501847 4149 716786
SGTC_691 1548-0686 185 µM -1.00199955930251 0.205956975634893 no 2743 0.158171902846188 4083 46495133
SGTC_1257 0669-0121 16 µM -1.00208628920076 0.205936736712918 no 2744 0.158150959622817 4110 4307855
SGTC_2479 5617353 43.85 µM -1.00282733768372 0.205763856883617 no 2745 0.157972088119811 4148 2731746
SGTC_898 1000-0849 28.3 µM -1.00794865728103 0.20457145598097 no 2746 0.156739555484478 4093 6751807
SGTC_570 0987-0065 62.6 µM -1.00819201328489 0.204514897729049 no 2747 0.156681145667534 3867 3104428
SGTC_3353 9151644 39.2805 µM -1.00886042035392 0.204359601450714 no 2748 0.156520789678562 4139 4909158
SGTC_790 1575-0012 79.1 µM -1.01005094836091 0.204083170642315 no 2749 0.156235440599485 4162 378741 YLR208W SEC13
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.0101107061872 0.204069301240039 no 2750 0.156221126715215 3927 4000243
SGTC_593 1203-0218 61.7 µM -1.01029352648806 0.204026873325691 no 2751 0.1561773408516 4127 3666956
SGTC_1619 st003326 88.7 µM -1.01058997518501 0.203958086339 no 2752 0.156106357925151 4099 2849032
SGTC_1494 4358-1428 177 µM -1.01106538647882 0.203847802311324 no 2753 0.155992567830303 4129 1564571
SGTC_843 0310-0051 143 µM -1.01158899374002 0.203726379112928 no 2754 0.155867305268832 4123 2065037
SGTC_1663 st014140 55.4 µM -1.01312146256806 0.203371251336905 no 2755 0.155501073917105 4178 4207120
SGTC_3073 9114972 49.47 µM -1.01514515252667 0.202902856436401 no 2756 0.15501832043947 4121 41905075
SGTC_3076 9116187 49.47 µM -1.01683266209338 0.202512765587068 no 2757 0.154616520688487 4091 27241210
SGTC_1484 3473-2379 286 µM -1.01684704774708 0.202509442075567 no 2758 0.154613098393893 4216 671917
SGTC_1312 1218-2183 165 µM -1.01822081022359 0.202192212571313 no 2759 0.154286515955198 4140 6744073
SGTC_2353 9059630 146.67 µM -1.0203798777953 0.201694241489272 no 2760 0.153774166661634 4148 4779114
SGTC_2135 5326629 150.42 µM -1.02046913844265 0.201673670083501 no 2761 0.153753009275091 4067 5020077
SGTC_1977 st070720 65.3 µM -1.02126054696057 0.201491333530106 no 2762 0.153565506574895 4139 682188
SGTC_2080 5212524 12.4 µM -1.02150737924655 0.201434484824977 no 2763 0.153507057376776 3998 260183
SGTC_279 1273-0055 2.93 µM -1.02164039108842 0.201403854443365 no 2764 0.153475566652775 4124 2847562
SGTC_1712 st032288 53.4 µM -1.02236268859261 0.201237570266573 no 2765 0.15330463650103 4009 2883011
SGTC_2963 9082507 9 µM -1.02341245512191 0.200996044404696 no 2766 0.153056436459035 4166 16459611
SGTC_3063 1327-0034 4 µM -1.02354288734447 0.200966047258503 no 2767 0.153025616517909 4010 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2657 nystatin 74.44 µM -1.02554791488345 0.200505263800187 no 2768 0.152552364567948 4137 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3355 9151058 44.0485 µM -1.0257712594651 0.20045397538625 no 2769 0.152499708132567 4100 17015728
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.0273614039279 0.200089045532591 no 2770 0.152125159219293 4140 7104
SGTC_2513 baicalein 25.65 µM -1.02737979638025 0.200084826898453 no 2771 0.152120830565141 4128 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2938 9059746 27.26 µM -1.0282121438675 0.199893969250594 no 2772 0.15192502362062 4116 6471769
SGTC_1990 st072050 59.8 µM -1.0297877490794 0.199532982198641 no 2773 0.151554826446422 4107 17233948
SGTC_2619 obliquin 87.91 µM -1.02985955798507 0.199516539407744 no 2774 0.151537968846469 4070 6708593 A bioactive alkalod. YER133W GLC7
SGTC_665 3914-0008 307 µM -1.03292434505117 0.198815525429057 no 2775 0.150819652413676 4062 1069549
SGTC_1239 0337-0584 35.4 µM -1.0343315039227 0.198494161574921 no 2776 0.150490606895232 4199 914301 YML130C ERO1
SGTC_537 1334-0398 209 µM -1.03452448689672 0.198450112995364 no 2777 0.150445517693179 4176 5846986
SGTC_2020 4017018 200 µM -1.03552279268759 0.198222342762161 no 2778 0.150212413826178 4195 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1751 st044839 27.194 µM -1.03588620893024 0.198139466077936 no 2779 0.150127616126838 4148 5291326
SGTC_1063 disulfiram 1.84 µM -1.03704787370707 0.19787469002118 no 2780 0.149856773235829 4131 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2641 levomentholum 100 µM -1.03944044402915 0.197330029896888 no 2781 0.149299971328636 4133 16666
SGTC_3026 9090633 49.47 µM -1.04079112796169 0.197022952353177 no 2782 0.148986249276782 4128 25236842
SGTC_2767 sibutramine 71.45 µM -1.04087230435856 0.197004506144695 no 2783 0.148967408553446 4168 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1005 4092-0690 4.4 µM -1.04208482537274 0.196729102025086 no 2784 0.14868617664515 4163 1529343
SGTC_1187 1391-0724 117 µM -1.04469895214902 0.196136140122107 no 2785 0.148081064643711 4175 6997986
SGTC_1121 fusaric acid 630.51 nM -1.04758676260375 0.195482360161595 no 2786 0.147414519462275 4096 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3339 9145883 14.936 µM -1.04827046281635 0.195327769231793 no 2787 0.147257007120462 4042 2030670
SGTC_1277 0873-0036 22 µM -1.05335078992665 0.194181388379513 no 2788 0.146090124525713 4225 5965735
SGTC_1838 st055369 84.5 µM -1.0545479709171 0.193911841110454 no 2789 0.145816055026035 4143 676036
SGTC_1045 1348-1485 165 µM -1.05557429116547 0.193680945050895 no 2790 0.145581375799884 4126 6810614
SGTC_1808 st050063 61.5 µM -1.05664128710111 0.19344107581386 no 2791 0.145337665046957 4138 4011993
SGTC_1061 3448-9325 110 µM -1.05716001249974 0.193324527687427 no 2792 0.145219283054232 4081 723482
SGTC_2262 9014885 67.46 µM -1.05762411158936 0.193220289422751 no 2793 0.145113422726103 4109 6457424
SGTC_343 4130-2827 29.8 µM -1.06104326849721 0.192453392750584 no 2794 0.144335118974368 4174 1118244
SGTC_1169 aniline yellow 25.8 µM -1.0633722023433 0.191932093722978 no 2795 0.143806596819745 4081 6051 A DNA damaging agent.
SGTC_1882 5615643 20 µM -1.06449811673266 0.1916803838717 no 2796 0.143551553544663 4113 2253075
SGTC_1635 st007035 42.4 µM -1.06470851911815 0.19163336866337 no 2797 0.143503926861567 4130 3716403
SGTC_2926 9010726 65.15 µM -1.06583167553655 0.191382514622429 no 2798 0.143249869642139 4196 2994293
SGTC_1190 1486-1332 13 µM -1.06689067951031 0.19114617327823 no 2799 0.143010602066098 4146 4150046
SGTC_125 0133-0007 11.75 µM -1.06718005475026 0.191081623612979 no 2800 0.142945268660023 4239 26541
SGTC_620 0109-0052 432 µM -1.06813723007381 0.190868205964028 no 2801 0.142729307071783 4158 493037
SGTC_2036 5160441 105 µM -1.06875377599238 0.190730814592987 no 2802 0.142590316462035 4131 134534 YIL048W NEO1
SGTC_587 k089-0003 57 µM -1.07047233468146 0.190348170680461 no 2803 0.142203377605346 4039 9659696
SGTC_3182 9108849 49.47 µM -1.07143267996732 0.190134551495836 no 2804 0.141987462623306 4199 17133045
SGTC_1044 1222-0021 1.78 µM -1.0736106970409 0.18965061962643 no 2805 0.141498600617506 4129 4306703
SGTC_1119 parthenolide 318.541 nM -1.0755407256611 0.189222421900246 no 2806 0.141066354508845 4271 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_413 propylparaben 100 µM -1.07597083706993 0.189127078202908 no 2807 0.140970149590476 4121 7175 A pharmaceutical preservative.
SGTC_1688 st021091 57.6 µM -1.07765377226098 0.188754302866241 no 2808 0.140594147839083 4192 3656366
SGTC_2944 9067346 25.62 µM -1.07775554977169 0.188731773364494 no 2809 0.140571430534239 4126 6473075
SGTC_1142 3253-1408 9.78 µM -1.07827859664783 0.18861601769167 no 2810 0.140454722876874 4191 256655
SGTC_1411 3909-8223 150 µM -1.07875712256801 0.188510153315539 no 2811 0.140348006838406 4192 X1411
SGTC_2413 inermin 26.06 µM -1.0835229720473 0.187457804241398 no 2812 0.13928818001392 4267 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1392 3455-1037 33.9 µM -1.08451909861224 0.187238308777375 no 2813 0.139067351820408 4181 981132
SGTC_2424 5537928 59.2 µM -1.0847158252119 0.187194979072807 no 2814 0.139023768309284 4197 5382802
SGTC_829 1635-0120 117 µM -1.08601846609014 0.186908224469479 no 2815 0.138735411254271 4186 285054
SGTC_1212 0520-0165 585 µM -1.08726123459078 0.186634903274034 no 2816 0.138460687729364 4326 5403258
SGTC_8 0354-0001 70 µM -1.08930269396775 0.18618646401295 no 2817 0.138010212588701 4170 4993152
SGTC_923 1900-2434 73.3 µM -1.0903739110161 0.18595142138519 no 2818 0.137774234625968 4141 5910570
SGTC_2610 ononetin 44.17 µM -1.0915768333917 0.185687699854127 no 2819 0.137509571700996 4174 259632
SGTC_3295 9122362 53.5725 µM -1.09192381535734 0.185611672736752 no 2820 0.137433294438787 4207 4730473
SGTC_2225 6654152 15.4 µM -1.09988959448598 0.183871608104179 no 2821 0.135690114488494 4090 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1469 k284-2957 126 µM -1.1013832816278 0.183546458114804 no 2822 0.135364939281322 4189 23884841
SGTC_978 1416-0512 87.4 µM -1.10169165083956 0.183479376097215 no 2823 0.135297873974224 4280 6814003
SGTC_2821 7996764 71.43 µM -1.10373113839731 0.183036094941923 no 2824 0.134854891967468 4253 2987135
SGTC_728 3030-5151 22.5 µM -1.10396662320257 0.182984955552726 no 2825 0.134803808205263 4262 3125388
SGTC_1811 st050069 61.5 µM -1.10521103236703 0.182714859750471 no 2826 0.134534078768282 4167 3877702
SGTC_2602 kawain 100 µM -1.10725050778864 0.182272735445857 no 2827 0.134092817937009 4197 5369129
SGTC_2063 5246145 200 µM -1.11134112376607 0.181387975333926 no 2828 0.133210772238084 4242 711240
SGTC_643 k048-0106 28.4 µM -1.11222216012021 0.18119776832181 no 2829 0.13302132109816 4220 6763920
SGTC_3024 9090631 49.47 µM -1.11368820697291 0.180881540355121 no 2830 0.132706485148207 4175 25236383
SGTC_1575 cyproterone acetate 48 µM -1.11442634513768 0.180722454117765 no 2831 0.132548163187241 4210 9880 An androgen receptor antagonist and liver toxin.
SGTC_2335 9018011 154.17 µM -1.11499390576711 0.180600191051413 no 2832 0.132426516636141 4203 6458208
SGTC_1440 4100-1550 40 µM -1.11507502615132 0.180582720456738 no 2833 0.132409136206971 4206 742806
SGTC_1644 st010134 20.9 µM -1.11522932875987 0.180549491804908 no 2834 0.132376080476391 4184 3818134
SGTC_845 0330-0138 4.51 µM -1.11534047097887 0.180525560002965 no 2835 0.132352274375293 4170 9039800
SGTC_2930 9013230 14.89 µM -1.11809942724308 0.179932123010463 no 2836 0.131762265520548 4228 2995857
SGTC_1555 citronellol 128 µM -1.11882764584303 0.179775691604906 no 2837 0.131606837550553 4166 8842 A terpine precursor.
SGTC_758 0868-0029 16 µM -1.11928368026225 0.179677772635912 no 2838 0.13150956790549 4222 762687
SGTC_1189 1431-2119 7.28 µM -1.12053775280468 0.179408673050609 no 2839 0.131242337014413 4207 3107275
SGTC_2760 etidronate 98.04 µM -1.12111965469178 0.179283894326865 no 2840 0.131118466741289 4168 3305 A chelator and antioxidant.
SGTC_2045 5106652 78.05 µM -1.12318707251825 0.178841014122483 no 2841 0.130679025898024 4191 673349
SGTC_3027 9089541 49.47 µM -1.12462664121059 0.178533038194021 no 2842 0.130373639758663 4223 9943819
SGTC_2388 9080168 200 µM -1.12473229274966 0.17851044866498 no 2843 0.130351246592578 4212 15943073
SGTC_612 0302-0167 22.4 µM -1.12487315059504 0.178480334418088 no 2844 0.130321395480978 4220 235821
SGTC_3179 9107801 49.47 µM -1.12598267119391 0.178243239945487 no 2845 0.130086427137312 4216 4818259
SGTC_1141 3253-0389 52.6 µM -1.12661258393665 0.178108721692285 no 2846 0.129953158142309 4216 5402031
SGTC_3176 9106582 49.47 µM -1.12801354510709 0.177809775094883 no 2847 0.12965709938277 4178 17018027
SGTC_776 4476-4378 112 µM -1.12852948426303 0.177699760290278 no 2848 0.129548186098541 4274 2892008
SGTC_338 4055-0136 114 µM -1.12954474230674 0.177483400092999 no 2849 0.129334053130849 4198 2900563
SGTC_647 0140-0236 81 µM -1.13109134163939 0.17715412625708 no 2850 0.129008324088558 4236 990837
SGTC_1402 3909-7673 35.9 µM -1.13171909530031 0.177020586517942 no 2851 0.128876275438329 4230 5328014
SGTC_394 menadione 8.33 µM -1.13222085786284 0.176913894152144 no 2852 0.128770796586038 4210 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2461 5755302 26.15 µM -1.1328359017174 0.176783169649425 no 2853 0.128641585837717 4269 2788904
SGTC_225 nsc-122657 1.016 µM -1.13319657601116 0.176706538538267 no 2854 0.128565855875268 4232 275685
SGTC_45 0kpi-0036 14.9 µM -1.13394990266807 0.176546549810413 no 2855 0.128407781402261 4260 2795021
SGTC_1101 ebselen 5.29 µM -1.13436108756767 0.17645926254439 no 2856 0.128321557268202 4266 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_787 4152-0075 138 µM -1.13436605779184 0.176458207620908 no 2857 0.128320515274341 4240 9566539
SGTC_2115 tiliquinol 12.7705 µM -1.13563087630101 0.176189881261281 no 2858 0.128055540495899 4202 71208 A bioactive hydroxyquinoline.
SGTC_1021 4476-0760 85.3 µM -1.13673818936179 0.175955181201614 no 2859 0.127823874762331 4228 746768
SGTC_1283 0922-0125 16.4 µM -1.14143699373398 0.174961452003228 no 2860 0.126844058725691 4231 3360884
SGTC_961 1252-1571 372 µM -1.14183541189231 0.174877356412723 no 2861 0.12676121989163 4246 6813498
SGTC_2515 chrysin 20.77 µM -1.14299051969502 0.174633688575674 no 2862 0.126521263610251 4255 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1395 3486-0190 4.35 µM -1.14418645651441 0.174381635194213 no 2863 0.126273159296772 4227 6748079
SGTC_705 1124-0212 310 µM -1.15052133404 0.173050365554591 no 2864 0.124964606232095 4239 9554485
SGTC_2486 5283202 22.39 µM -1.15230617562987 0.172676454570743 no 2865 0.124597640071724 4281 1377751
SGTC_697 0508-1955 564 µM -1.15592088176399 0.171920779771572 no 2866 0.123856760219385 4247 6243113
SGTC_3319 9138450 16.7555 µM -1.15824644024686 0.171435726555139 no 2867 0.123381740774055 4182 2029690
SGTC_1789 tunicamycin 25 nM -1.15859029202369 0.171364081987478 no 2868 0.123311613934489 4144 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_134 0269-0018 6.916 µM -1.15961453688134 0.171150784920084 no 2869 0.123102889857478 4210 4378915
SGTC_947 3447-0010 211 µM -1.15970899540745 0.171131122664003 no 2870 0.123083653259258 4203 748350
SGTC_1483 3453-0561 55.9 µM -1.16140031442521 0.170779306355369 no 2871 0.122739570591415 4274 4546991
SGTC_523 1934-0222 13.7 µM -1.16281116695195 0.170486185089663 no 2872 0.122453062708836 4197 1361595
SGTC_1300 1094-0077 113 µM -1.16387696910146 0.170264965861465 no 2873 0.122236937100252 4221 5532636
SGTC_808 0711-0032 135 µM -1.1639682491858 0.170246028206165 no 2874 0.122218439589366 4232 4252555
SGTC_1226 3909-7979 35.4 µM -1.16494881018566 0.170042678737467 no 2875 0.12201985711455 4251 6615510
SGTC_786 4544-0069 423 µM -1.16505763106209 0.170020120984367 no 2876 0.121997832770047 4246 748821 YLR208W SEC13
SGTC_2780 5215298 71.43 µM -1.16792392323811 0.169426650783454 no 2877 0.121418726632585 4272 2834131
SGTC_188 3229-0966 278.469 µM -1.1696485779699 0.169070199768485 no 2878 0.1210712098301 4292 5722370
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.17019185012572 0.168958016297632 no 2879 0.120961885909948 4252 390807
SGTC_2750 bromebric acid 70.15 µM -1.17078018260133 0.168836581997271 no 2880 0.120843572758194 4291 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3095 9117207 49.47 µM -1.17088805250195 0.168814323280476 no 2881 0.120821889052721 4233 17015229
SGTC_3307 9126885 69.2785 µM -1.17334222424933 0.168308419833462 no 2882 0.120329298049655 4213 24824909
SGTC_1561 5-methoxyflavone 52.9 µM -1.17525509306279 0.167914777643805 no 2883 0.119946337398477 4211 94525
SGTC_2761 levamisole 97.89 µM -1.17897009066653 0.167151976654474 no 2884 0.119205042904809 4282 26879 An alkaline phosphatase inhibitor.
SGTC_1103 duloxetine 36.1 µM -1.17941564407881 0.167060641378356 no 2885 0.119116354363746 4344 60835 A selective serotonin reuptake inhibitor.
SGTC_2910 7948405 25.97 µM -1.18055654883293 0.166826910768054 no 2886 0.118889466758283 4177 2971328
SGTC_2907 7721985 69.9 µM -1.18369898677921 0.166184228859734 no 2887 0.11826612010225 4280 3267881
SGTC_1997 st073024 93.8 µM -1.18669225336686 0.165573544279891 no 2888 0.117674515882715 4290 686268
SGTC_2820 7989630 71.43 µM -1.18731627888903 0.165446414000845 no 2889 0.117551444666927 4312 2984098
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.18885104935771 0.165134009934242 no 2890 0.117249142754584 4318 368090
SGTC_170 4197-0004 226 µM -1.18985827603663 0.164929195600524 no 2891 0.117051050035742 4279 218692
SGTC_1070 indatraline 8.81 µM -1.19148034652794 0.164599701896878 no 2892 0.116732533783423 4310 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1883 5-benzylidenerhodanine 20 µM -1.19170394383803 0.16455431570269 no 2893 0.116688675559029 4253 1273210
SGTC_3045 9092950 49.47 µM -1.19663559418502 0.163555342687383 no 2894 0.115724310276206 4263 44120432
SGTC_1177 0983-0204 23.6 µM -1.1973773434001 0.163405432680714 no 2895 0.115579755221775 4303 766818
SGTC_1895 st058434 18.3 µM -1.19760535493901 0.163359368723343 no 2896 0.115535345209798 4295 5393175
SGTC_3211 9128781 49.47 µM -1.20109802440838 0.162654817702356 no 2897 0.114856589647832 4262 17194361
SGTC_103 0844-0104 51.839 µM -1.20452816349968 0.161964807335065 no 2898 0.114192751672224 4146 5375804
SGTC_152 4469-0003 551.229 µM -1.20659275117789 0.16155041330874 no 2899 0.113794509874391 4272 697280
SGTC_1309 pyrazolanthrone 13.4 µM -1.20885976460054 0.161096186286643 no 2900 0.113358363119989 4260 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_130 0136-0219 337.655 µM -1.2100756732675 0.160852906114115 no 2901 0.113124928423859 4121 234244
SGTC_1117 retinoic acid 1.10837 µM -1.21824289656634 0.159225019966494 no 2902 0.111565841436031 4338 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_538 2922-0838 53.3 µM -1.21872756889132 0.159128755710716 no 2903 0.111473805290659 4313 777039
SGTC_2763 lisinopril 49.32 µM -1.22004113549512 0.158868050522976 no 2904 0.111224640691825 4219 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_370 0180-0345 38.7 µM -1.22133537420141 0.15861145531079 no 2905 0.110979532546432 4144 3989527
SGTC_2880 9042983 58.44 µM -1.2226377483596 0.158353521650292 no 2906 0.110733274470041 4265 6464714
SGTC_2715 st079500 56.4 µM -1.223491383196 0.158184609662037 no 2907 0.110572078387788 4277 28246688
SGTC_156 3474-0145 5.642 µM -1.22374385308452 0.158134675146187 no 2908 0.110524435497185 4206 2265471
SGTC_929 2805-0021 398 µM -1.2253816640385 0.1578109935514 no 2909 0.110215726093627 4369 3098024
SGTC_2055 5235184 200 µM -1.22690226785016 0.157510865486275 no 2910 0.109929663045523 4351 2836034
SGTC_21 0849-0113 22.993 µM -1.22865061746747 0.157166250132556 no 2911 0.10960141433627 4269 1560156
SGTC_1303 1160-0052 261 µM -1.23154716951083 0.156596405779295 no 2912 0.109059143073883 4255 3562476
SGTC_2595 hexamethylquercetagetin 100 µM -1.23414900437186 0.156085702777894 no 2913 0.108573692925442 4322 386331
SGTC_380 3970-0968 6 µM -1.2376657495337 0.155397162230901 no 2914 0.107920011976156 4186 2891601
SGTC_762 1165-0429 115 µM -1.23827562591907 0.155277959290405 no 2915 0.107806939154237 4315 5967793
SGTC_3127 9126946 49.47 µM -1.23896644982636 0.155143007728951 no 2916 0.107678961535697 4292 27243249
SGTC_993 3909-8757 62.7 µM -1.24133332191098 0.154681229589681 no 2917 0.107241319944889 4257 4288324 YLR208W SEC13
SGTC_2125 5246583 200 µM -1.24137789778092 0.154672541533661 no 2918 0.107233090057993 4335 835267
SGTC_1920 st075728 45.7 µM -1.24329787140511 0.15429863530125 no 2919 0.106879044157182 4311 3400306
SGTC_561 1550-0330 72.9 µM -1.24539287535239 0.153891325191223 no 2920 0.1064936854608 4270 6812934
SGTC_1197 1601-0112 267 µM -1.24579452962373 0.153813317036541 no 2921 0.106419919209194 4295 7350313
SGTC_212 3807-4682 38.772 µM -1.24860076214533 0.153269028849668 no 2922 0.105905566729697 4392 3125501 YBL034C STU1
SGTC_1939 st074455 53.6 µM -1.24870061974283 0.153249684321475 no 2923 0.105887297059125 4308 1644229
SGTC_3202 9113761 49.47 µM -1.24955656426778 0.15308393613595 no 2924 0.105730789246298 4271 4798415
SGTC_2927 9011802 47.9 µM -1.25049313115501 0.152902712133331 no 2925 0.105559731470549 4320 43912568
SGTC_33 0986-0033 35.816 µM -1.25270321813164 0.152475628414648 no 2926 0.105156867188395 4294 2848082
SGTC_2449 5812982 45.77 µM -1.25416288243398 0.152193993072769 no 2927 0.104891404029432 4260 776185
SGTC_2794 7785382 27.27 µM -1.25584004399601 0.151870819358781 no 2928 0.104586984952402 4328 2205081
SGTC_2505 galangin 7.89 µM -1.2563080315246 0.151780723855247 no 2929 0.104502155557125 4224 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1215 3852-0577 11.2 µM -1.25800549199915 0.151454232138399 no 2930 0.104194885031872 4370 2884876
SGTC_772 k072-0172 35.3 µM -1.26543182126289 0.150031336452782 no 2931 0.102858287089224 4396 5861980
SGTC_300 r073-0011 5.04 µM -1.26613996639043 0.149896121793538 no 2932 0.102731488036675 4335 2735780
SGTC_1597 7-benzyloxygramine 47.5 µM -1.26658879900736 0.149810462880282 no 2933 0.102651179805224 4243 260807
SGTC_1275 0867-0008 21.1 µM -1.26731596276785 0.149671754271947 no 2934 0.102521167510639 4314 3422836
SGTC_2913 7966556 36.57 µM -1.26944796709167 0.149265562281234 no 2935 0.10214066872304 4238 2976516
SGTC_3281 9140613 49.47 µM -1.27204161592823 0.14877241050462 no 2936 0.101679166691031 4347 16013766
SGTC_462 ag-879 158 µM -1.27208048042762 0.148765029168224 no 2937 0.101672262883789 4380 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3049 9092223 49.47 µM -1.27313272023514 0.148565275646029 no 2938 0.101485474929906 4331 8623917
SGTC_2162 5663267 200 µM -1.27399780123123 0.148401186081748 no 2939 0.101332097708079 4350 6456493
SGTC_54 0159-0055 9 µM -1.27412800565843 0.148376499254387 no 2940 0.101309027339271 4348 3319099
SGTC_2493 resveratrol 26.09 µM -1.27426134409371 0.148351221064354 no 2941 0.101285405635167 4268 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2564 betulinic acid 100 µM -1.27530692311513 0.148153100920285 no 2942 0.101100314134675 4387 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1588 farnesol 29.9 µM -1.27697563550075 0.147837274093914 no 2943 0.100805424596667 4365 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3021 9087658 49.47 µM -1.2817093984835 0.146943798878792 no 2944 0.0999723033838205 4350 25237042
SGTC_1705 st027868 56.3335 µM -1.2821210674828 0.146866269845375 no 2945 0.0999000898291752 4288 292948
SGTC_1001 4048-4355 44.4 µM -1.28439078291204 0.14643931032317 no 2946 0.0995026281750258 4347 21824233
SGTC_3154 9100113 49.47 µM -1.28522225052471 0.146283110466817 no 2947 0.0993573151890353 4350 25237525
SGTC_847 0342-0274 5.54 µM -1.28576831007974 0.146180588377523 no 2948 0.0992619665115339 4355 18097
SGTC_2327 6189656 200 µM -1.28675969511455 0.145994580282884 no 2949 0.0990890295849382 4430 5349088
SGTC_3078 9116413 49.47 µM -1.28831427339974 0.145703223680405 no 2950 0.0988182932594083 4287 17177322
SGTC_2431 5490079 200 µM -1.28966047592387 0.145451236548403 no 2951 0.0985842841009502 4394 5722345
SGTC_2152 5568786 200 µM -1.2914027663763 0.145125543625015 no 2952 0.0982820259378458 4382 5399883
SGTC_183 3914-0051 30.55 µM -1.29202577961652 0.145009200633568 no 2953 0.0981741085111564 4369 1596232
SGTC_2371 9071574 200 µM -1.29215269817683 0.144985507256204 no 2954 0.0981521345143722 4363 45596039
SGTC_2645 abamectin 100 µM -1.29448609391574 0.144550369270712 no 2955 0.0977487847958362 4313 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_919 tnp00227 403.569 nM -1.29777495578916 0.143938548827777 no 2956 0.0971823389660377 4315 1269246 A methoxyflavone. YNL221C POP1
SGTC_3324 9138759 60.749 µM -1.29864325128662 0.143777313413113 no 2957 0.0970331937938428 4396 45595710
SGTC_2616 abietic acid 100 µM -1.30023017110171 0.143482950290528 no 2958 0.09676104638902 4397 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2544 sphondin 68.51 µM -1.30033168957909 0.143464133140903 no 2959 0.096743655663583 4322 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1071 trifluoperazine 6.31 µM -1.30454731693904 0.142684208432623 no 2960 0.0960235187499111 4419 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_883 0850-0245 24.6 µM -1.30484829267515 0.142628635367267 no 2961 0.0959722555605113 4435 6823229 YPR165W RHO1
SGTC_1176 0848-0131 83.3 µM -1.30543732730206 0.142519916596793 no 2962 0.0958719874632722 4423 6769040
SGTC_936 3005-4620 401 µM -1.30567614783431 0.142475853200543 no 2963 0.0958313563288775 4405 777207
SGTC_424 splitomicin 100 mM -1.31010541088532 0.141660305552418 no 2964 0.0950800891164496 4393 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_754 3474-0146 171 µM -1.3123858128094 0.141241657176533 no 2965 0.0946949956463612 4363 24762078
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.31463212212643 0.14083008853757 no 2966 0.0943167845255514 4410 6710655
SGTC_862 0452-0056 10.2 µM -1.31570798632476 0.140633257233213 no 2967 0.0941360363279442 4333 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1462 k081-0014 26.5 µM -1.31852968097364 0.140117910446168 no 2968 0.0936631979557093 3832 3270634
SGTC_1383 3049-0032 20.7 µM -1.31910333681151 0.140013296601519 no 2969 0.0935672838924894 4439 712864
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.32240917795858 0.139411466393984 no 2970 0.0930159671537784 4378 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_185 k048-0037 25.491 µM -1.32281963655299 0.13933686517726 no 2971 0.0929476827020126 4414 6827589
SGTC_611 3453-1652 23.7 µM -1.32718613885743 0.138544930783656 no 2972 0.0922235582153668 4396 1560575
SGTC_812 4251-0442 148 µM -1.32852339736497 0.138303012398286 no 2973 0.0920026296781029 4403 5723007
SGTC_2441 5730946 39.09 µM -1.33043388379698 0.137957893339262 no 2974 0.0916876783790473 4441 1774275
SGTC_1249 0481-0015 10.2 µM -1.33162545886377 0.137742939433728 no 2975 0.0914916473778811 4312 4227577
SGTC_2085 5307070 144.047 µM -1.33704261291088 0.136768595341338 no 2976 0.0906043638011766 4333 2840351
SGTC_449 xestospongin c 11.1929 µM -1.33755281125406 0.136677073052168 no 2977 0.0905211279258867 4402 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_418 lividomycin a 100 µM -1.33970722685838 0.136291063505881 no 2978 0.0901702735547022 4399 72394 An antibiotic.
SGTC_3185 9108267 49.47 µM -1.34421089865824 0.135486545923203 no 2979 0.0894400991770372 4400 4910486
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.35831551840117 0.132988037365595 no 2980 0.0871817940943407 4364 6708739 YPR165W RHO1
SGTC_848 0368-0089 85.6 µM -1.36856619702256 0.131192242679318 no 2981 0.0855674582154277 4400 762535
SGTC_68 0986-0284 82.829 µM -1.36966755216387 0.131000299793911 no 2982 0.0853953509962252 4421 423278 YIL048W NEO1
SGTC_2467 5474540 200 µM -1.37049706320233 0.130855861743948 no 2983 0.0852658957614545 4396 5413519
SGTC_962 1254-0300 21.5 µM -1.37575683589723 0.129942569048804 no 2984 0.0844484645382398 4387 7340576
SGTC_113 0099-0221 2.5 µM -1.37737893268883 0.129661804951029 no 2985 0.0841975614148586 4382 89219
SGTC_2330 7979373 200 µM -1.37920398693829 0.129346414176299 no 2986 0.0839159345814419 4356 1863007
SGTC_3061 glucosamine 200 µM -1.37995318421003 0.129217098150549 no 2987 0.0838005298584903 4351 91431 and experimental redox chemotherapeutic
SGTC_1340 1486-1359 257 µM -1.38281373194779 0.128724174609272 no 2988 0.0833609936719218 4368 4309068
SGTC_1938 st074717 56.4 µM -1.38551473830901 0.12825994181115 no 2989 0.0829475645295093 4291 17250979
SGTC_3008 9078912 71.4286 µM -1.38614051465393 0.128152553203313 no 2990 0.0828520006033481 4436 16648731
SGTC_2899 9053889 58.44 µM -1.38631878895969 0.128121971230437 no 2991 0.0828247910387274 4404 6470052
SGTC_2303 7774051 200 µM -1.39075433272617 0.127362709826977 no 2992 0.0821499677700696 4426 2953184
SGTC_1307 1187-1599 12.2 µM -1.39452073610853 0.126720451135841 no 2993 0.0815802060798671 4429 1538471
SGTC_2581 avocatin a 64 µM -1.40419023804783 0.125081916671026 no 2994 0.0801311039954681 4378 6710728 A skin care supplement.
SGTC_3173 9105693 49.47 µM -1.40759871554765 0.124507879835848 no 2995 0.0796249640064564 4410 17096658
SGTC_893 0958-0369 48.9 µM -1.40896086144392 0.124278990701596 no 2996 0.0794233707346669 4325 6819948
SGTC_557 1315-0110 16.2 µM -1.4098116117253 0.124136183683728 no 2997 0.0792976585106112 4432 6833801
SGTC_1336 1486-0901 104 µM -1.41212293834089 0.123748783969747 no 2998 0.0789568828776481 4444 5006114
SGTC_1284 0929-0043 16 µM -1.41306421235044 0.123591260532892 no 2999 0.0788184223223278 4449 1239883
SGTC_2207 7258803 200 µM -1.41306462602486 0.123591191334822 no 3000 0.0788183615116638 4461 3666799
SGTC_2629 bisabolol 100 µM -1.41409290320741 0.123419268422508 no 3001 0.0786673132965272 4470 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2033 5192550 145 µM -1.41445381173356 0.123358966022059 no 3002 0.078614349878811 4461 182073
SGTC_1961 st076550 68.7 µM -1.41487766561497 0.12328817275719 no 3003 0.0785521837266144 4459 1579337
SGTC_294 k038-0071 157 µM -1.41583510612352 0.12312836314886 no 3004 0.0784118942128685 4462 24152826
SGTC_1856 st057054 55.7 µM -1.41658094165166 0.123003973881445 no 3005 0.0783027419285658 4432 1266018
SGTC_2069 5228469 200 µM -1.41695680179323 0.12294132191801 no 3006 0.0782477788552741 4452 2835210
SGTC_1364 1653-0028 37.6 µM -1.42396608722777 0.12177704475889 no 3007 0.0772281446372996 4448 5718652
SGTC_3268 9137683 49.47 µM -1.42882947179166 0.120973778429039 no 3008 0.0765266262851025 4518 1953228
SGTC_606 k015-0008 38.6 µM -1.43054343651395 0.120691579975499 no 3009 0.0762805542219105 4509 1970475
SGTC_605 1315-0399 119 µM -1.4318661142696 0.120474122620703 no 3010 0.0760910707971958 4524 24020461
SGTC_263 alizarin 107.927 µM -1.43367024781189 0.120177955695981 no 3011 0.0758331932103282 4494 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1748 st037455 53.6035 µM -1.43505455372205 0.119951055865631 no 3012 0.0756357762685422 4468 580690
SGTC_1151 3909-8316 15.3 µM -1.43589146532975 0.119814025303608 no 3013 0.0755166137127499 4494 800431
SGTC_1461 k072-0203 53.8 µM -1.43611824075664 0.119776913556951 no 3014 0.0754843492397086 4363 5418714
SGTC_1495 4469-0029 237 µM -1.43915178997613 0.119281253224768 no 3015 0.075053760588121 4461 793680
SGTC_3195 9113082 49.47 µM -1.44164303648426 0.118875285226677 no 3016 0.0747015504923361 4454 17018038
SGTC_640 3381-0960 37.1 µM -1.4418035459128 0.118849162469479 no 3017 0.0746789011428911 4513 1745025
SGTC_565 1418-0001 44.5 µM -1.44201193949336 0.118815252661629 no 3018 0.0746495027207138 4501 2862145
SGTC_1859 st055998 20 µM -1.44335161423689 0.118597423934763 no 3019 0.0744607234735891 4390 676301
SGTC_2575 plumbagin 510 nM -1.45046672070854 0.117445249668794 no 3020 0.0734642064939156 4383 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2217 6934799 96.0675 µM -1.45067533414062 0.117411588177821 no 3021 0.073435143483437 4440 675606
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.45185922125555 0.117220687664711 no 3022 0.0732703766004528 4449 689007
SGTC_909 3448-9333 149 µM -1.45186216950871 0.117220212536699 no 3023 0.0732699666321475 4396 3344074
SGTC_1715 st032160 10.2275 µM -1.45395808265179 0.116882789171102 no 3024 0.0729789639866713 4381 5289825
SGTC_59 0330-0160 1.33 µM -1.45415390162992 0.116851299258967 no 3025 0.072951821162565 4432 4293482
SGTC_2429 5902844 64.44 µM -1.45426316379228 0.116833731278391 no 3026 0.0729366794948824 4451 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_382 3229-0966 23.2 µM -1.45599122108259 0.116556130353692 no 3027 0.0726975232373107 4504 5722370
SGTC_2047 4141938 200 µM -1.4560450747918 0.116547486635723 no 3028 0.0726900797584746 4486 3807862
SGTC_2851 9015922 71.43 µM -1.45723872503392 0.116356018089706 no 3029 0.0725252472196029 4484 2996893
SGTC_3118 9124250 49.47 µM -1.45957056158323 0.115982621779929 no 3030 0.0722040674086691 4428 1504786
SGTC_14 0354-0009 295 µM -1.46164948115051 0.115650442966944 no 3031 0.071918643791548 4567 1713507
SGTC_2134 5324836 1.464 µM -1.46271257131985 0.115480839192498 no 3032 0.0717730224001772 4453 699272
SGTC_2240 6690706 185.951 µM -1.46557136450183 0.115025628602097 no 3033 0.0713825486071974 4370 805876
SGTC_326 k292-0812 17.5 µM -1.46654342759131 0.114871136414354 no 3034 0.0712501496089958 4453 3579357
SGTC_292 k038-0015 474 µM -1.46826132912625 0.114598467475782 no 3035 0.071016625452493 4470 46368540
SGTC_1025 k007-0731 70 µM -1.47365498902987 0.113745368823314 no 3036 0.0702872538278021 4461 6256118
SGTC_2165 5727197 32.143 µM -1.47417172578846 0.113663876388889 no 3037 0.0702176802572971 4534 1361712
SGTC_344 k064-0035 6.43 µM -1.47597072491732 0.113380488324832 no 3038 0.0699758756928055 4435 5088750
SGTC_2167 5876490 200 µM -1.47668801272393 0.113267637907646 no 3039 0.0698796434511912 4505 686534
SGTC_2349 9023730 187.07 µM -1.47706876435698 0.113207767070627 no 3040 0.069828602724967 4516 4126287
SGTC_2000 st075254 36.4 µM -1.47943916440506 0.112835544129091 no 3041 0.0695114896640866 4366 17234175
SGTC_2692 st077426 47.7 µM -1.48978215221656 0.111221613789643 no 3042 0.0681407627212341 4476 25238571
SGTC_87 0100-0052 35.5 µM -1.49047931538142 0.11111342536843 no 3043 0.0680491256251389 4509 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3221 9128209 49.47 µM -1.49141799728313 0.110967876228702 no 3044 0.0679258929516569 4510 16460723
SGTC_2397 5161689 200 µM -1.49326129354991 0.110682457859285 no 3045 0.067684401631979 4509 2259942
SGTC_2675 theaflavin digallate 100 µM -1.4940394935506 0.11056211844238 no 3046 0.0675826485299923 4423 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_713 1488-1073 324 µM -1.50320158558951 0.109152357019908 no 3047 0.0663935343959771 4534 3312542
SGTC_696 1560-0013 611 µM -1.50386664490218 0.109050530194852 no 3048 0.0663078534642282 4530 1650269
SGTC_568 1193-0097 7.48 µM -1.50449007371526 0.108955139403134 no 3049 0.0662276136519251 4290 3646150
SGTC_2772 vinpocetine 57.06 µM -1.50896886332046 0.108271603149919 no 3050 0.0656533699957752 4502 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_846 0335-0850 148 µM -1.50971025701324 0.108158752774175 no 3051 0.065558686441328 4487 6819598
SGTC_247 mechlorethamine 29.705 µM -1.50995889882612 0.108120925017092 no 3052 0.0655269560606764 4452 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3080 9117754 49.47 µM -1.50997455178373 0.108118543933125 no 3053 0.0655249589098169 4500 9550191
SGTC_312 4092-0653 6.84 µM -1.51989955576002 0.106616371763531 no 3054 0.0642681110714543 4396 1148278
SGTC_2981 9013952 38.96 µM -1.54095096327478 0.103480182014959 no 3055 0.0616643604937018 4460 2996344
SGTC_2130 NSC 7 2.4545 µM -1.54119510075805 0.103444208000338 no 3056 0.0616346547639587 4559 21448
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.54131485821896 0.103426564882502 no 3057 0.0616200872125351 4540 4174840
SGTC_1298 1079-1278 263 µM -1.54255933891808 0.103243352594511 no 3058 0.0614688650303641 4495 2840950
SGTC_506 n9-isopropylolomoucine 153 µM -1.5431472790543 0.103156878134681 no 3059 0.0613975227992575 4516 6610355
SGTC_1382 3002-2117 298 µM -1.54575117248074 0.102774528804212 no 3060 0.0610823367086256 4567 1497314
SGTC_1863 st057641 20.1 µM -1.54731251350135 0.10254575977994 no 3061 0.0608939528660776 4564 3921635
SGTC_1132 3456-3614 2.5 µM -1.54740054367276 0.102532872557171 no 3062 0.0608833451150112 4505 3125502
SGTC_1713 st033146 12.748 µM -1.54970816818777 0.10219546654341 no 3063 0.0606057883679275 4491 674619
SGTC_1602 st001878 87.6 µM -1.55462207044033 0.101479679967693 no 3064 0.0600180521330841 4497 595405 YLR310C CDC25
SGTC_109 0132-0036 33.701 µM -1.55491538567891 0.101437069802228 no 3065 0.0599831112875765 4425 67274 A color developer.
SGTC_2096 5468907 200 µM -1.55500780882862 0.101423646109666 no 3066 0.0599721047858075 4525 759785
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.55615140496287 0.101257655348679 no 3067 0.059836046867148 4493 97141
SGTC_2991 9074669 71.4286 µM -1.55643768757628 0.101216132977993 no 3068 0.0598020246214474 4484 17333109
SGTC_450 aminopyrene 156 nM -1.55988006950643 0.100717821872143 no 3069 0.059394112583163 4490 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1332 1480-0653 17.5 µM -1.5628860126049 0.100284154016399 no 3070 0.0590397041023445 4528 5749438
SGTC_3275 9138069 49.47 µM -1.56546373902237 0.0999133518491332 no 3071 0.0587371066439442 4574 17617007
SGTC_2928 9011484 9.79 µM -1.56650638420936 0.0997636536355865 no 3072 0.0586150575786952 4521 2994751
SGTC_2900 5328528 85.29 µM -1.56669739468131 0.0997362469956601 no 3073 0.0585927200317417 4522 795359
SGTC_74 000s-0487 160.283 µM -1.5676253629097 0.0996031781631241 no 3074 0.0584842947139176 4399 677548
SGTC_1193 1488-0126 41.5 µM -1.56813982610197 0.0995294610695878 no 3075 0.0584242519176111 4505 1384710
SGTC_2589 lobaric acid 100 µM -1.57307541567207 0.098824269050659 no 3076 0.0578506783434719 4463 73157 A novel microtubule depolymerizer.
SGTC_1720 st037298 9.481 µM -1.57407500457087 0.0986818951101263 no 3077 0.0577350551986919 4509 597396
SGTC_1374 2889-5571 141 µM -1.57760835690942 0.0981798342064193 no 3078 0.0573278056630491 4523 2853281
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.58122792871337 0.0976674650772187 no 3079 0.0569129658473896 4537 641818 YHR062C RPP1
SGTC_3178 9107506 49.47 µM -1.58349981327895 0.0973468711211092 no 3080 0.0566537945945031 4511 8897194
SGTC_2770 toltrazuril 17.5 µM -1.58506421672917 0.0971265616986621 no 3081 0.0564758723337468 4468 68591 Kills coccidiodes.
SGTC_1081 sertraline 6 µM -1.58563367765389 0.0970464574347948 no 3082 0.0564112160037446 4532 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1205 4161-2785 76 µM -1.58647079823841 0.0969287903889141 no 3083 0.0563162756548567 4531 3498106
SGTC_206 4546-0025 72.014 µM -1.58741600777771 0.0967960561224583 no 3084 0.0562092280673378 4569 6620745 YIL048W NEO1
SGTC_1643 st009866 20.2 µM -1.58838437076088 0.0966602089261669 no 3085 0.0560997247307075 4514 3156273 YOR207C RET1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.58869861824718 0.0966161546987656 no 3086 0.0560642255264276 4479 6708514
SGTC_22 0964-0034 14.468 µM -1.59016512138778 0.0964107612258733 no 3087 0.0558987950872882 4550 138402
SGTC_208 k072-0098 12.366 µM -1.59225658471978 0.0961183932948596 no 3088 0.0556635318571813 4541 5948901
SGTC_1500 4488-1866 171 µM -1.59436171436829 0.0958247737041182 no 3089 0.0554275211760923 4587 2900003
SGTC_888 0916-0002 6.97 µM -1.59438652187205 0.0958213175370279 no 3090 0.0554247446702917 4550 2802138 YIL048W NEO1
SGTC_3012 9080433 71.4286 µM -1.59515770684591 0.0957139222188161 no 3091 0.0553384868505327 4523 17688859
SGTC_3103 9120822 49.47 µM -1.59686135905233 0.0954769853514565 no 3092 0.0551483074154596 4545 17141819
SGTC_1085 doxorubicin 7.67 µM -1.59708967152823 0.0954452654333644 no 3093 0.055122860074134 4547 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2636 apigenin dimethyl ether 100 µM -1.59709288319873 0.0954448192847607 no 3094 0.0551225021726808 4511 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1664 st014217 9.02 µM -1.60148584213144 0.094836008296716 no 3095 0.0546346766618411 4619 3982782
SGTC_2799 7812892 81.82 µM -1.60281137429552 0.094652868746523 no 3096 0.054488152434202 4570 20205235
SGTC_2828 7998861 71.43 µM -1.60734740040543 0.0940281300000546 no 3097 0.053989090851755 4553 2988188
SGTC_137 0438-0332 85.389 µM -1.61121495556417 0.0934978660661097 no 3098 0.0535664396117788 4498 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1921 5740136 50 µM -1.61259715391121 0.0933088954625135 no 3099 0.0534160286120799 4489 1774243
SGTC_545 4218-0007 221 µM -1.61852927450972 0.0925010749198187 no 3100 0.0527742915808023 4560 2840508
SGTC_739 1486-1183 203 µM -1.6200312286949 0.0922973660675898 no 3101 0.052612784387545 4544 4346692
SGTC_723 4182-0001 115 µM -1.62043239260006 0.0922430127519657 no 3102 0.0525697131254317 4554 744821 YLR208W SEC13
SGTC_23 0213-0011 39.996 µM -1.62603287465068 0.091486681256193 no 3103 0.0519713310539454 4547 627608
SGTC_2050 5263056 171 µM -1.62761516392632 0.0912738319529732 no 3104 0.0518032558654761 4531 763468 YGL055W OLE1
SGTC_548 1436-0017 110 µM -1.62899851453081 0.0910880448576033 no 3105 0.0516566667080028 4587 9677137
SGTC_2651 TUB2.036 5 µM -1.63352273281882 0.0904823908482492 no 3106 0.0511795517998842 4454 15992207 YFL037W TUB2
SGTC_634 1611-4317 11.2 µM -1.63422203934603 0.0903890425737841 no 3107 0.0511061182302967 4578 2843522
SGTC_2008 4012253 172 µM -1.64401600466256 0.0890891815546032 no 3108 0.0500864482401045 4565 603940
SGTC_2185 6113692 200 µM -1.64425780538966 0.0890572665216862 no 3109 0.0500614805564483 4558 874150
SGTC_1337 1486-1011 40.3 µM -1.64455278245161 0.0890183443216532 no 3110 0.050031035467921 4566 X1337
SGTC_684 1140-0066 328 µM -1.64522894133609 0.0889291729896481 no 3111 0.0499613036570844 4569 6813534
SGTC_1017 4239-0030 168 µM -1.64721671205316 0.0886674123757898 no 3112 0.049756754975714 4580 1149593
SGTC_2580 diallyl disulphide 81.36 µM -1.64735383444353 0.0886493765238396 no 3113 0.0497426692634399 4537 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2916 7875993 68.79 µM -1.6473615326276 0.0886483640546212 no 3114 0.0497418785722049 4471 1299250
SGTC_2876 9059903 25.97 µM -1.64980585564864 0.0883273207576248 no 3115 0.0494913253713313 4558 6916095
SGTC_794 k038-0031 316 µM -1.65562238249845 0.0875668494109091 no 3116 0.0488991572819944 4550 6624242
SGTC_817 1391-0715 46 µM -1.65930297879435 0.0870881669169871 no 3117 0.0485273776695343 4564 1353946
SGTC_877 0771-0151 33.1 µM -1.66111978602993 0.0868526024412583 no 3118 0.0483446957009156 4576 6166523
SGTC_1998 st075797 76.8 µM -1.66517350950466 0.0863287194404766 no 3119 0.0479390721949251 4568 24208315
SGTC_781 4335-2806 94.4 µM -1.66688383121463 0.0861083962105176 no 3120 0.0477687532741218 4604 845254
SGTC_2682 pyrogallin 40.03 µM -1.66701885378244 0.0860910205678969 no 3121 0.0477553279871995 4587 822798 An ATP competetive kinase inhibitor.
SGTC_1056 3448-1962 115 µM -1.66868504407209 0.0858768194783593 no 3122 0.0475899073333684 4529 715507
SGTC_671 0560-0003 407 µM -1.67436695021717 0.0851493674715804 no 3123 0.0470292519960164 4544 3238678
SGTC_3226 9131256 49.47 µM -1.68149099453891 0.0842438158178537 no 3124 0.0463337920958847 4598 17178073
SGTC_2942 9052777 62.25 µM -1.68486307007114 0.0838177132435283 no 3125 0.0460074965370102 4581 6469503
SGTC_333 3486-0131 40.1 µM -1.68493653823756 0.0838084477029484 no 3126 0.0460004080636475 4596 6744690
SGTC_410 α-linolenic acid 100 µM -1.68689384027159 0.0835618829996528 no 3127 0.0458118833624942 4612 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_191 3914-0123 66.505 µM -1.69050371834265 0.083108570770637 no 3128 0.0454658137441099 4649 3144412
SGTC_2097 5376186 200 µM -1.69675714503122 0.0823276740678032 no 3129 0.0448712919623797 4562 742755
SGTC_377 3970-0964 33.1 µM -1.69858413661917 0.0821005747085517 no 3130 0.0446987837439742 4578 16481235
SGTC_998 3996-0085 177 µM -1.70164822148528 0.0817207616664983 no 3131 0.0444106660882716 4617 715391
SGTC_2649 anisomycin 9.56 µM -1.70251025090137 0.0816141466806489 no 3132 0.0443298792501378 4637 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1486 3970-0793 4.53 µM -1.70333010503643 0.0815128452274665 no 3133 0.044253154879772 4635 2844330
SGTC_3291 9121177 71.43 µM -1.7072781739017 0.0810263478767764 no 3134 0.043885180452202 4564 17015612
SGTC_95 0471-0001 561.058 µM -1.71075554944678 0.0805996692661456 no 3135 0.0435631241917019 4572 4015405
SGTC_2344 7990960 76.95 µM -1.71241091155282 0.0803971513266419 no 3136 0.0434104848082127 4581 140813
SGTC_2725 haloperidol 53.21 µM -1.71672911510988 0.079870669690545 no 3137 0.0430143389152177 4560 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_463 ikarugamyin 104 µM -1.71698260945456 0.0798398445079816 no 3138 0.0429911747620908 4729 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2914 7968218 45.32 µM -1.71709674119203 0.0798259689048112 no 3139 0.0429807487669781 4580 2977111
SGTC_2159 5658611 73.75 µM -1.7180595661537 0.079708985730683 no 3140 0.0428928754834503 4578 793844
SGTC_1717 st033143 58.0435 µM -1.71833985638694 0.079674954868412 no 3141 0.0428673217874717 4592 674616
SGTC_2539 epi(13)torulosol 80 µM -1.72034709456086 0.0794315713041222 no 3142 0.0426846838306542 4564 6708597
SGTC_2236 dapsone 200 µM -1.72500145724587 0.0788693816737584 no 3143 0.0422636049492245 4625 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1624 st003710 6.25 µM -1.72505641180991 0.0788627618927241 no 3144 0.0422586533738169 4626 24207033
SGTC_2690 usnic acid 100 µM -1.72539543426215 0.078821932838461 no 3145 0.0422281167858703 4597 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2977 9011197 71.43 µM -1.72668373215284 0.0786669269709839 no 3146 0.0421122394196902 4620 2704722
SGTC_275 trichlorophene 5.69 µM -1.72764402973524 0.0785515359131958 no 3147 0.0420260319158613 4628 62616
SGTC_163 TUB2.036 7.546 µM -1.72924385440788 0.0783595831277063 no 3148 0.0418827302770588 4544 15992207 YJR013W GPI14
SGTC_1699 st031318 29.054 µM -1.7326734496588 0.0779492865852336 no 3149 0.0415768630687031 4654 5340658
SGTC_886 0866-0150 153 µM -1.73410411512524 0.0777786128556331 no 3150 0.0414498057543914 4622 271463
SGTC_1051 3253-3903 78 µM -1.73585929234226 0.0775696135601736 no 3151 0.0412943585615857 4600 5509239
SGTC_2840 9008771 71.43 µM -1.73641331872844 0.0775037309960114 no 3152 0.0412453894770599 4558 2992978
SGTC_505 gw-5074 63.9 µM -1.73865656753953 0.0772374072603297 no 3153 0.0410475949980116 4596 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3081 9117243 49.47 µM -1.73931524958952 0.0771593391900566 no 3154 0.0409896631982257 4564 45595589
SGTC_746 1095-0025 46.6 µM -1.73940748508066 0.077148412076743 no 3155 0.0409815562826085 4612 6749286
SGTC_1970 st070122 35.8 µM -1.73987362807211 0.0770932062314553 no 3156 0.0409406051573911 4611 102928
SGTC_1116 jasmonic acid 1.58368 µM -1.74195227443142 0.0768473951316736 no 3157 0.0407583978569094 4640 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.74570487512692 0.0764051394465085 no 3158 0.0404311237678673 4627 1273210
SGTC_2038 4100038 30.985 µM -1.75447716724858 0.075378854761195 no 3159 0.0396743894684523 4571 3596803
SGTC_3105 9121040 49.47 µM -1.75595166827059 0.0752073868085015 no 3160 0.0395483307584894 4600 41448907
SGTC_24 0417-1663 219 µM -1.75802519881022 0.0749667617885598 no 3161 0.0393716109154367 4631 4329390
SGTC_1171 0368-0077 21.4 µM -1.75842997553551 0.0749198576304521 no 3162 0.0393371882586046 4583 3239779
SGTC_2785 7756463 72.73 µM -1.75859704534295 0.074900504674023 no 3163 0.0393229876003462 4584 2201551
SGTC_3303 9125618 40.5795 µM -1.76251957723223 0.074447223284274 no 3164 0.0389907758248698 4594 22695467
SGTC_1885 st057546 99.9 µM -1.7646805647969 0.0741983993759687 no 3165 0.0388087333798597 4633 702008
SGTC_1305 1181-0477 144 µM -1.76506594066936 0.0741540926215202 no 3166 0.0387763420162865 4638 6252086
SGTC_3288 9119690 36.221 µM -1.76555500213763 0.0740978942094036 no 3167 0.0387352674485042 4596 17595618 YKL019W RAM2
SGTC_3149 9097855 49.47 µM -1.76982694277973 0.0736083848526202 no 3168 0.0383779870579313 4601 25236625 YMR079W SEC14
SGTC_1253 0550-0034 176 µM -1.77102057192897 0.0734720532299147 no 3169 0.0382786404223982 4597 5969915
SGTC_496 calpeptin 138 µM -1.77434383419698 0.0730935005086718 no 3170 0.0380031470569502 4597 73364 A calpain inhibitor.
SGTC_2699 st077704 54.6 µM -1.78064991652114 0.0723792804917629 no 3171 0.0374848298782801 4606 645852
SGTC_3143 9086658 49.47 µM -1.78108833795305 0.0723298248618845 no 3172 0.0374490102979277 4572 25236626
SGTC_1145 3546-0597 10.2 µM -1.782519351209 0.0721685812266394 no 3173 0.0373322892099988 4608 875334
SGTC_3253 9135987 49.47 µM -1.78965142307526 0.0713690596464835 no 3174 0.0367549830923588 4633 4182430
SGTC_399 oxolinic acid 75 µM -1.79263880349148 0.0710361947459058 no 3175 0.0365153487838177 4616 4628 A DNA gyrase inhibitor.
SGTC_944 3370-0224 231 µM -1.80754823618376 0.0693927288214877 no 3176 0.0353384204284418 4593 4580514
SGTC_3236 9132701 49.47 µM -1.81384771878897 0.0687072019890087 no 3177 0.0348505867941183 4647 24282524
SGTC_1499 4480-0877 67.3 µM -1.81765218189874 0.0682957264906099 no 3178 0.034558655327882 4650 2861909
SGTC_1578 josamycin 24.2 µM -1.81786387957136 0.0682728860920577 no 3179 0.0345424701071357 4622 5282165 A P450 substrate.
SGTC_753 1322-0200 289 µM -1.82357574958848 0.06765884604423 no 3180 0.0341081177706912 4676 5403907
SGTC_1976 st070609 63.5 µM -1.82699107966313 0.0672937331951153 no 3181 0.033850555311703 4591 682556
SGTC_1841 st054148 70 µM -1.83175035947996 0.0667874890605709 no 3182 0.0334943110216809 4650 675442
SGTC_1144 3486-0183 12.5 µM -1.83996754997836 0.0659203697327182 no 3183 0.0328865007829355 4648 6744069
SGTC_533 1222-0222 6.71 µM -1.84104031886307 0.0658078125368764 no 3184 0.0328078252243606 4661 3982874
SGTC_938 3126-1755 342 µM -1.84320836875501 0.065580790920794 no 3185 0.0326492967443625 4632 1777771
SGTC_1962 st076595 64.5 µM -1.84581574102363 0.0653085716823889 no 3186 0.0324594821101612 4604 279619
SGTC_2722 naftopidil 47.16 µM -1.8470207200803 0.0651830639796335 no 3187 0.0323720686797485 4587 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.85275264325079 0.06458860171036 no 3188 0.031958910384809 4641 2374 Ca(2+)-ATPase inhibitor.
SGTC_1853 st056710 91.2 µM -1.85654621261983 0.0641974892384441 no 3189 0.0316878712226202 4655 269167
SGTC_317 4495-0002 170 µM -1.85685322161397 0.0641659176726141 no 3190 0.0316660196782267 4655 15991618
SGTC_1511 0906-3109 28.5 µM -1.85832477612704 0.0640147564886036 no 3191 0.0315614537403952 4646 2882180
SGTC_381 3461-2219 42.7 µM -1.85993273838216 0.0638498999450339 no 3192 0.0314475213917075 4629 2883159
SGTC_1513 0337-0559 19 µM -1.86466857322377 0.0633662759686517 no 3193 0.0311139372241541 4622 775073
SGTC_2818 7996756 12.99 µM -1.86660904686586 0.063168940091291 no 3194 0.0309781016502497 4654 2241621
SGTC_1659 st012954 42.1 µM -1.87668204524162 0.0621522496620645 no 3195 0.0302808424520037 4650 24207262
SGTC_1064 honokiol 6.76 µM -1.87823234626747 0.0619969141887201 no 3196 0.0301746934952583 4646 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2250 alverine citrate 130 µM -1.88118311791804 0.0617020930234109 no 3197 0.0299735067015563 4519 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1093 fluphenazine 7.97 µM -1.88149994776669 0.0616705027094633 no 3198 0.0299519711878962 4674 6602611 An atypical antipsychotic.
SGTC_1435 4092-0789 56.7 µM -1.88397087621348 0.0614245657017658 no 3199 0.029784457503343 4669 2248285
SGTC_1186 1319-0216 26 µM -1.89093654796804 0.0607353799621477 no 3200 0.0293164074609394 4683 4565136
SGTC_2948 9070189 9.45 µM -1.89161505234248 0.0606685730524449 no 3201 0.0292711444408033 4588 6473636 YDL196W YDL196W
SGTC_1149 3909-7961 23.3 µM -1.89335352858411 0.0604976614770507 no 3202 0.0291554355259835 4681 735261
SGTC_2600 tangeritin 87.95 µM -1.8998087921933 0.0598663317867701 no 3203 0.0287291083512242 4592 68077 A bioactive flavone.
SGTC_404 fumagillin 50 µM -1.90707891975843 0.0591614994130758 no 3204 0.0282551842881842 4668 12015870 A methionine aminopeptidase binder.
SGTC_1314 1222-0010 41.1 µM -1.91168680137589 0.0587181499766339 no 3205 0.027958189121544 4666 3526027
SGTC_2885 9057732 51.95 µM -1.91183665194673 0.0587037759377901 no 3206 0.0279485745134084 4654 6471414
SGTC_1166 k206-0078 225 µM -1.91240876686932 0.0586489226544006 no 3207 0.0279118921983674 4668 5404595
SGTC_2844 9010103 25.97 µM -1.91689951378686 0.0582197547576723 no 3208 0.0276253494349196 4610 2480525
SGTC_3010 9080089 71.4286 µM -1.92263570654026 0.057675156062722 no 3209 0.0272629082198018 4677 17027233
SGTC_853 0419-0306 21 µM -1.9256053159733 0.0573947970365534 no 3210 0.027076837222294 4718 762713
SGTC_3259 9138485 49.47 µM -1.92657575355438 0.0573034114238296 no 3211 0.027016261373229 4632 17646153
SGTC_1778 st046819 58.9 µM -1.92688259918247 0.0572745397651531 no 3212 0.0269971312619785 4701 671715
SGTC_813 k007-0158 173 µM -1.93411050567712 0.0565977581260882 no 3213 0.0265497712582001 4663 6523916
SGTC_207 4185-0010 4.486 µM -1.93951059792918 0.0560962476488207 no 3214 0.0262195976607618 4684 3761753
SGTC_1370 2001-0092 44.6 µM -1.94168670233919 0.0558951446121581 no 3215 0.0260875197420832 4633 790957
SGTC_3352 9151559 45.5865 µM -1.94490368664857 0.0555988918445304 no 3216 0.0258932856275677 4667 17159339
SGTC_2698 st077697 67.5 µM -1.9517107541564 0.0549761140784841 no 3217 0.0254862775454526 4647 3154499
SGTC_859 0439-0102 54.6 µM -1.95509523371703 0.0546685269207394 no 3218 0.0252859153697958 4688 610143
SGTC_2107 5363541 170.161 µM -1.95513608027046 0.0546648230446793 no 3219 0.0252835053250906 4624 244052
SGTC_1693 xanthone 101.9 µM -1.95757446769286 0.0544440746388865 no 3220 0.0251399828856246 4708 7020 An insecticide.
SGTC_460 trequinsin 123 µM -1.9631732104767 0.0539398858293336 no 3221 0.0248130255356411 4742 5537 A vasodilator.
SGTC_1388 3346-4487 254 µM -1.97681443549277 0.0527269115689312 no 3222 0.0240313046838241 4691 3345614
SGTC_2783 7738165 71.43 µM -1.98020695512116 0.0524286352827503 no 3223 0.0238401393346106 4664 17201110
SGTC_2394 5221648 200 µM -1.98260079325733 0.0522189720820174 no 3224 0.0237060193535161 4671 788586
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.98790764559532 0.0517565482781146 no 3225 0.0234109525100415 4683 2333 A French combination drug.
SGTC_1442 4112-3290 3 µM -1.98876986678698 0.0516817251284088 no 3226 0.0233633051181361 4705 704353
SGTC_1077 5-fluorocytosine 377 nM -1.99008868599944 0.0515674450000826 no 3227 0.0232905834537289 4705 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1804 st050076 49.1 µM -1.99122675512241 0.0514689890659605 no 3228 0.0232279818497741 4696 3895976
SGTC_2998 9066762 71.4286 µM -1.99279509345216 0.0513335549711077 no 3229 0.0231419446327352 4673 4945196
SGTC_2793 7325131 81.82 µM -1.99971874797726 0.05073904670799 no 3230 0.0227653212881524 4638 4176441
SGTC_1675 st018485 24.5 µM -1.99981926931668 0.0507304558702536 no 3231 0.0227598915361481 4673 3323024
SGTC_799 1310-0557 151 µM -2.00179630600003 0.0505617280386129 no 3232 0.0226533217081355 4692 5354492
SGTC_2395 5646831 180.19 µM -2.0057812506699 0.0502229964718822 no 3233 0.0224397959581473 4635 6808628
SGTC_2131 toluylene red 5.2905 µM -2.02994094507318 0.048207912550873 no 3234 0.0211812712243673 4643 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1042 0350-0096 82 µM -2.04241483486805 0.0471931177432854 no 3235 0.0205551997221244 4678 3122515
SGTC_2786 7743617 45.45 µM -2.04898270322233 0.0466657209827957 no 3236 0.0202319031532722 4630 583674
SGTC_425 3825-7017 13.1 µM -2.04985802498726 0.0465957915731814 no 3237 0.0201891436613217 4674 3397440
SGTC_480 am 92016 50 µM -2.05167416010895 0.0464509688803114 no 3238 0.0201006698061317 4696 2129 K+ channel blocker.
SGTC_1706 st031321 9.9705 µM -2.05975727010781 0.0458107806900103 no 3239 0.0197108756961373 4714 6103185
SGTC_874 0599-0792 117 µM -2.06168292130425 0.0456593183241327 no 3240 0.0196189668038306 4688 765305
SGTC_2848 9016370 25.97 µM -2.06188772794246 0.045643232941596 no 3241 0.0196092130870966 4662 7894410
SGTC_1008 4106-0037 6 µM -2.06839643368858 0.0451344118823232 no 3242 0.0193013801487201 4717 2905394
SGTC_1346 1488-2224 62.4 µM -2.06942927213583 0.0450540904904069 no 3243 0.0192529110002651 4702 3722427
SGTC_2865 9030313 51.95 µM -2.07136288901393 0.0449040270095632 no 3244 0.0191624481228937 4680 42562754
SGTC_934 2950-0684 338 µM -2.07456747670477 0.0446562127135015 no 3245 0.0190133194859868 4689 1121253
SGTC_2952 9073731 13.78 µM -2.07499234390932 0.0446234401233907 no 3246 0.0189936221713469 4668 16457353
SGTC_2179 6298986 200 µM -2.0778101626399 0.0444065746552516 no 3247 0.0188634237187514 4669 738374
SGTC_2545 solidagenone 89.61 µM -2.08417881105224 0.0439195579955841 no 3248 0.0185719526899938 4699 6708572 An anti ulcer agent
SGTC_3004 9076122 71.4286 µM -2.08651357545749 0.0437420990791638 no 3249 0.0184660633991391 4694 44782551
SGTC_2229 7354935 190 µM -2.09016846519782 0.043465463194062 no 3250 0.018301334607599 4704 318112
SGTC_2310 7668677 200 µM -2.09392540030701 0.0431825772849567 no 3251 0.0181333130917625 4655 2197143
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.09625744293848 0.0430077307481084 no 3252 0.0180296798618195 4684 688803
SGTC_2249 haloperidol 116.36 µM -2.10273986786008 0.0425247096422623 no 3253 0.0177442574963496 4640 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1455 4262-0120 131 µM -2.10319913017072 0.0424906559844851 no 3254 0.0177241831505863 4719 1529587
SGTC_2868 9035608 32.47 µM -2.11161325023138 0.0418706550368562 no 3255 0.0173598175627676 4701 6462614
SGTC_228 caffeine 993.056 µM -2.12489374716388 0.0409069950944208 no 3256 0.0167977399219419 4709 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1490 4089-0339 670 nM -2.12663124182939 0.0407822605654664 no 3257 0.0167253672821063 4722 742542
SGTC_1527 coumarin 137 µM -2.13075182813459 0.0404876777603337 no 3258 0.016554796410629 4715 323 A hepatotoxic, DNA x-linker.
SGTC_716 1683-5115 658 µM -2.13137815787216 0.0404430527538474 no 3259 0.0165290004093112 4701 723597
SGTC_1497 4476-2978 41.3 µM -2.14574408244774 0.0394304200245828 no 3260 0.0159467010404682 4740 1528379
SGTC_668 1682-0499 62.6 µM -2.15351275771658 0.0388914697342298 no 3261 0.0156392012715686 4722 682214
SGTC_173 1273-0061 2.693 µM -2.15779426023199 0.0385970150889008 no 3262 0.015471915675334 4673 2847414 YPL266W DIM1
SGTC_3214 9129694 49.47 µM -2.15931272896801 0.0384930218192204 no 3263 0.0154129566380544 4695 17158655
SGTC_3144 9087057 49.47 µM -2.1632205964137 0.0382264389094793 no 3264 0.0152621084275206 4656 17249618
SGTC_1851 st056236 18.9 µM -2.17065547189971 0.037723411507161 no 3265 0.0149786127522127 4700 5393171
SGTC_1423 4048-0112 5.59 µM -2.19598314800757 0.0360502087831283 no 3266 0.0140465748002027 4758 X1423
SGTC_2689 tacrolimus 100 µM -2.2005052216443 0.0357579626876425 no 3267 0.013885534938779 4699 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2502 avocadyne acetate 18.59 µM -2.21894037906086 0.0345865860363106 no 3268 0.013245390477575 4714 3952079
SGTC_452 diindolylmethane 8 µM -2.23310778931359 0.0337079606689908 no 3269 0.012770918535101 4718 3071 Inhibits expression of several cancer promoting factors.
SGTC_2318 6029776 164 µM -2.2389264398471 0.0333524637920342 no 3270 0.0125803514114484 4711 818325
SGTC_2739 tacrine 100.86 µM -2.25275456347525 0.0325199945835291 no 3271 0.0121373142525399 4752 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1744 st037937 38.9 µM -2.25485303983083 0.0323951745879537 no 3272 0.0120712773812078 4727 1016152
SGTC_1034 k072-0165 12.7 µM -2.29504594256873 0.0300797616331598 no 3273 0.0108652457646292 4742 5835461
SGTC_2813 7971799 71.43 µM -2.30337024066852 0.0296177881095453 no 3274 0.0106290103288055 4708 2234054
SGTC_2190 6049624 200 µM -2.31329002364655 0.029074975075107 no 3275 0.010353349415143 4706 2265554
SGTC_2150 5556613 200 µM -2.31576483100464 0.0289408489307094 no 3276 0.0102855562209262 4759 743190
SGTC_513 4245-1575 41.7 µM -2.31675786764866 0.0288871744869546 no 3277 0.0102584626654944 4601 719745
SGTC_2557 derrustone 83.84 µM -2.31746078741166 0.0288492311344433 no 3278 0.0102393221658763 4731 629853 An antioxidant.
SGTC_100 0086-0128 49.5915 µM -2.32095343698296 0.028661313040506 no 3279 0.0101446785150937 4729 93297
SGTC_1514 1189-1591 158 µM -2.3213526213033 0.0286399003439303 no 3280 0.0101339101888546 4734 767698 YMR146C TIF34
SGTC_2565 isoliquiritigenin 100 µM -2.34135947150714 0.027583630657044 no 3281 0.00960682882271281 4707 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2226 7298446 200 µM -2.35487357802258 0.0268886830676923 no 3282 0.00926450417386864 4753 3283010
SGTC_2412 st077135 33.4 µM -2.3751987663437 0.0258710502753571 no 3283 0.00876975115706153 4725 13258915
SGTC_3133 9127736 49.47 µM -2.38250028072997 0.0255134381755854 no 3284 0.00859775943574551 4736 27243420
SGTC_298 1391-0729 10 µM -2.38855444177813 0.0252200664620359 no 3285 0.00845740101123668 4731 3237558
SGTC_747 3448-8087 38.7 µM -2.41184964214025 0.0241174653603507 no 3286 0.00793591272308449 4770 5168703
SGTC_323 4013-0906 34.3 µM -2.41517884534273 0.0239632458163902 no 3287 0.00786374257719753 4765 2910086
SGTC_2954 9074818 52.69 µM -2.42195375503428 0.0236519682003654 no 3288 0.007718657460337 4735 16648742
SGTC_1855 st056195 39.6 µM -2.42693318323786 0.023425359270551 no 3289 0.00761352997249434 4710 4028379
SGTC_1797 st048695 56.8 µM -2.42951492961258 0.0233085874337812 no 3290 0.00755952111121481 4741 592262 YIL048W NEO1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.44174676383807 0.022761982400669 no 3291 0.00730819770043876 4707 676296 Flavone; oxidizing agent.
SGTC_1562 morin hydrate 59.1 µM -2.4452755826835 0.0226063121114975 no 3292 0.00723707481881063 4744 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2276 7947513 42.08 µM -2.44534909336238 0.0226030788287774 no 3293 0.00723559973333283 4711 2105100
SGTC_53 0973-0023 39.979 µM -2.44824776608979 0.0224758944611138 no 3294 0.0071776451205598 4712 674768
SGTC_3209 9113616 49.47 µM -2.45030800106243 0.0223858653759791 no 3295 0.00713670311384294 4745 16649353
SGTC_3151 9099821 49.47 µM -2.4839917185403 0.0209565458276924 no 3296 0.00649594146706381 4722 17174189
SGTC_619 1652-1634 108 µM -2.49498399253584 0.0205071482106344 no 3297 0.00629814062357496 4746 5400454
SGTC_2073 5212005 126 µM -2.49954028926526 0.0203232810492235 no 3298 0.00621772790557148 4742 691789
SGTC_3217 9129673 49.47 µM -2.50662346392512 0.020040218570383 no 3299 0.00609452402879311 4736 17248312
SGTC_46 0329-0187a 2.197 µM -2.51148273492909 0.0198479692175498 no 3300 0.00601125833249365 4724 46494817
SGTC_1352 1496-0991 99 µM -2.51229331603598 0.019816052667446 no 3301 0.0059974672485513 4773 3000039
SGTC_675 1309-0189 238 µM -2.53709401113757 0.0188603719856768 no 3302 0.00558884664805854 4763 4246530
SGTC_2279 7948423 32.93 µM -2.5422259695981 0.0186675893126936 no 3303 0.00550744678053831 4731 1247112
SGTC_2210 7115885 190.385 µM -2.58053027662189 0.0172809791017879 no 3304 0.00493243527991293 4783 2927039
SGTC_2285 7945142 200 µM -2.61004039455674 0.0162736185220365 no 3305 0.00452657659162625 4754 2970608
SGTC_3128 9127691 49.47 µM -2.62640463250886 0.0157370006923437 no 3306 0.00431460847923199 4768 41316314
SGTC_1559 coumarin 343 70.1 µM -2.62757309092799 0.0156992718904054 no 3307 0.00429981824474217 4779 108770 A hepatotoxic, DNA x-linker.
SGTC_1910 st062352 60.4 µM -2.62860928261081 0.0156658788451472 no 3308 0.00428674016514072 4736 2245730
SGTC_402 epigallocatechin gallate 10 µM -2.64528024923986 0.0151369480171989 no 3309 0.00408116422228113 4761 65064 An antioxidant.
SGTC_2854 9024559 71.43 µM -2.66043117692676 0.0146696270928117 no 3310 0.00390203373161055 4755 3163529
SGTC_585 0kpi-0023 191 µM -2.66374815963073 0.0145689894771534 no 3311 0.00386376954509767 4751 64601
SGTC_1794 st048918 76.9 µM -2.67119748404575 0.0143451395713256 no 3312 0.00377905827906996 4783 672303
SGTC_2896 9052656 71.43 µM -2.69340406414692 0.0136953287835419 no 3313 0.00353632482413164 4477 6469436
SGTC_51 1013-0126 23.419 µM -2.71192703341071 0.0131728906424712 no 3314 0.00334466579970811 4766 1627850
SGTC_1519 esterone 74 µM -2.72776557023558 0.0127399140185993 no 3315 0.00318824533446369 4770 698 A steroid.
SGTC_1919 st067113 52.3 µM -2.73574066346342 0.0125265993115991 no 3316 0.00311200278759754 4747 1268243
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.74108000900353 0.0123855188881988 no 3317 0.00306187968817482 4763 551469
SGTC_1927 st060202 13.8 µM -2.74268128103937 0.0123434779648452 no 3318 0.00304699011706857 4758 688887
SGTC_1054 3429-0080 167 µM -2.74514721624922 0.0122789773410648 no 3319 0.00302418792147936 4766 1162877
SGTC_255 tunicamycin 200.472 nM -2.77080621080903 0.0116249677387981 no 3320 0.0027958847685284 4750 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_453 enantio-paf c16 10 µM -2.80240451390934 0.0108613003805508 no 3321 0.00253616146223012 4379 13871343 A lipid and platelet activating factor
SGTC_1583 clindamycin 39.6 µM -2.803205924224 0.0108425135019084 no 3322 0.00252986759205808 4782 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1434 4073-0095 163 µM -2.80444341952408 0.010813559358622 no 3323 0.00252017666390623 4798 24133745
SGTC_2009 4012297 12.05 µM -2.83365976507997 0.0101492567131815 no 3324 0.00230091491947895 4753 45595307
SGTC_189 3970-0742 2.116 µM -2.8999078207394 0.00877339410686686 no 3325 0.00186636207376613 4786 2891807
SGTC_1648 st011736 69.8 µM -2.90340523672939 0.00870553518606672 no 3326 0.00184564331254141 4792 2855514
SGTC_685 1278-0033 54.9 µM -2.92933971590808 0.00821654155495935 no 3327 0.00169841475713198 4792 3590572
SGTC_270 tamoxifen 5.46 µM -2.92989494134088 0.00820634208246841 no 3328 0.00169538310740834 4782 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_457 grayanotoxin iii 135 µM -2.9977733280449 0.00704023388856594 no 3329 0.0013597993296254 4683 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_41 0478-0632 82.643 µM -3.03537127733806 0.00645941251154335 no 3330 0.0012011987411853 4777 3750424
SGTC_114 0364-0001 490.298 µM -3.06005523470501 0.00610153423987294 no 3331 0.00110648087503513 4789 4003655
SGTC_1828 st055811 49 µM -3.06828179852306 0.00598622755342434 no 3332 0.00107646745965703 4799 5877589
SGTC_2116 5511452 16.8835 µM -3.11546827712308 0.0053614145864569 no 3333 0.000918265507500455 4798 870744
SGTC_334 1502-1024 68.5 µM -3.18772708920732 0.00451668130050079 no 3334 0.000716979042066262 4795 3296216
SGTC_406 estrone 100 µM -3.20636950328148 0.00431900057719316 no 3335 0.000672106293419829 4801 5870 A steroid.
SGTC_2292 7671323 168.05 µM -3.21711412866444 0.0042086131027436 no 3336 0.000647435391894148 4791 937504
SGTC_1690 st023502 41.2 µM -3.23474807183672 0.00403290733229502 no 3337 0.000608750523729806 4805 24207482
SGTC_1159 4092-0538 61.2 µM -3.25827127642216 0.00380875194574365 no 3338 0.000560465979712943 4801 717301
SGTC_1689 st020265 53.493 µM -3.29489330292263 0.00348195348632987 no 3339 0.00049229528046605 4805 5758320 YPR016C TIF6
SGTC_1035 k081-0041 55.2 µM -3.30050332896858 0.00343418055848638 no 3340 0.000482557843227343 4798 731709
SGTC_1134 3477-0009 42.5 µM -3.30674831279066 0.00338169389491112 no 3341 0.000471928274432345 4782 3973534
SGTC_1436 4092-1007 8.32 µM -3.39988096818925 0.00268004226586485 no 3342 0.000337075968639344 4800 2881121
SGTC_2284 7945075 39.21 µM -3.40081195542584 0.00267374713060769 no 3343 0.000335930138501061 4782 1245402
SGTC_1378 2093-0007 380 nM -3.42010201659264 0.00254628102181405 no 3344 0.000312988279653489 4799 3618014
SGTC_2002 4023503 131 µM -3.46349630568157 0.00227938799773712 no 3345 0.000266601958374396 4797 4736863 YCR052W RSC6
SGTC_1641 st009299 47.1 µM -3.47914991915889 0.00218951067485419 no 3346 0.000251503550957643 4806 4046054
SGTC_917 harmaline 728.087 nM -3.52178300066777 0.00196078062233324 no 3347 0.000214327433468346 4764 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_910 3454-3003 490 µM -3.59580552305655 0.00161460215333771 no 3348 0.000161694667034158 4775 820824
SGTC_3003 9075612 71.4286 µM -3.74264958694811 0.00108722961626349 no 3349 9.10450349460134e-05 4805 6501993
SGTC_2288 7946289 167.31 µM -3.75178251908758 0.00106034360890936 no 3350 8.77908729411418e-05 4803 1246052
SGTC_3126 9127922 49.47 µM -3.83996151172276 0.000830397026697809 yes 3351 6.15268002286379e-05 4780 45595682
SGTC_393 acivicin 6.25 µM -3.95214536926165 0.000604180321954959 yes 3352 3.87268314262929e-05 4795 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3129 9127257 49.47 µM -4.01060295543264 0.000510310205951873 yes 3353 3.02819418371121e-05 4801 837894
SGTC_1677 st019204 53.9 µM -4.46803068190942 0.000126381416159695 yes 3354 3.94714925702827e-06 4808 3945625
SGTC_2710 st078562 53.7235 µM -5.30696244388102 6.91363820339619e-06 yes 3355 5.57335664210028e-08 4808 17250908
SGTC_2283 7944793 200 µM -5.71199848104237 1.44604717180913e-06 yes 3356 5.58285426096759e-09 4808 2970533