SGTCid condition conc unit CWC15|YDR163W.score CWC15|YDR163W.strain.pval CWC15|YDR163W.strain.significant CWC15|YDR163W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2968 9090663 33.37 µM 8.22962513329426 6.22771310134284e-19 yes 1 9.39001111182062e-17 2 25236811
SGTC_2970 9090938 41.86 µM 5.7919709433905 3.07472093082507e-10 yes 2 3.47825899384363e-09 5 17217104
SGTC_2988 9073640 71.4286 µM 4.9895936909956 5.1078659542923e-08 yes 3 3.0253211365026e-07 12 9102229
SGTC_2049 5262831 67.185 µM 4.79113106053508 1.61752861131708e-07 yes 4 8.29218735570146e-07 14 763417
SGTC_2948 9070189 9.45 µM 4.62428127712336 4.11972721878141e-07 yes 5 1.87949747009046e-06 36 6473636 YDL196W YDL196W
SGTC_3141 9094609 49.47 µM 4.47185732415871 9.41771163498898e-07 yes 6 3.87715790923082e-06 27 25236309 YDL196W YDL196W
SGTC_1892 st058411 7.36 µM 4.2116350575069 3.63850143558405e-06 yes 7 1.26764450238621e-05 16 3934738
SGTC_2570 licareol 100 µM 4.17960637280879 4.27467403927162e-06 yes 8 1.4600705235372e-05 25 443158
SGTC_3098 9119039 49.47 µM 4.03783581093492 8.60420260739293e-06 yes 9 2.69732941502259e-05 33 17161528
SGTC_1359 1582-0056 520 nM 3.92294110534134 1.49215311067738e-05 yes 10 4.37372700376112e-05 19 3661189
SGTC_3308 9128332 17.569 µM 3.87419519250679 1.87644754302887e-05 yes 11 5.34888225882628e-05 79 17332805 YDL196W YDL196W
SGTC_3198 9112019 49.47 µM 3.84107903846893 2.18925772177496e-05 yes 12 6.12473308497955e-05 17 45595555
SGTC_50 0929-0078 56.389 µM 3.77678777428187 2.94299015991859e-05 yes 13 7.94319925156452e-05 52 1377751
SGTC_2255 7941087 197.44 µM 3.74973578489095 3.32859999208142e-05 yes 14 8.85104924739541e-05 37 935561
SGTC_2647 atorvastatin 60.16 µM 3.61313581539353 6.12233936355527e-05 yes 15 0.00015125807202493 25 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1360 1598-0022 39.8 µM 3.55984873188567 7.72213710283457e-05 yes 16 0.000185534237732122 47 761525
SGTC_2823 7987624 58.44 µM 3.55305245193382 7.95240753839065e-05 yes 17 0.000190394265511314 47 2239440
SGTC_2824 7998404 51.95 µM 3.38032382799879 0.000164979235245069 yes 18 0.000362002363332152 52 837851
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 3.34593235883756 0.000190036269859825 yes 19 0.000410031990401764 101 6708739 YPR165W RHO1
SGTC_3245 9134821 49.47 µM 3.27371567753009 0.000254655673220598 yes 20 0.000530716766899576 39 17014901
SGTC_1747 st037496 66.6 µM 3.18373766423506 0.000363809228103247 yes 21 0.000726933540252787 46 723305
SGTC_1679 SEC14.276 6.7 µM 3.10327282175788 0.000496787069922193 yes 22 0.000956965570439151 113 1005053 YMR079W SEC14
SGTC_571 k831-0106 44.2 µM 3.0430706683726 0.000624306151078496 yes 23 0.0011708866625083 41 4783639
SGTC_2193 5925765 200 µM 2.9942096987474 0.000749336117107839 yes 24 0.0013757838037383 24 877370
SGTC_10 0279-0212 42.575 µM 2.98243677462205 0.000782727882714334 yes 25 0.00142981853371787 199 39851 YBR002C RER2
SGTC_2713 st079149 53.4 µM 2.97099980086952 0.000816473773486448 yes 26 0.00148415986619023 67 3103253
SGTC_2048 5246248 200 µM 2.9546397708913 0.000867076860949761 yes 27 0.00156517160836346 29 677046
SGTC_3344 9148862 3.898 µM 2.93934202380706 0.000916987672647012 yes 28 0.0016445494749043 53 4905352
SGTC_2645 abamectin 100 µM 2.9384470311243 0.000919987885009851 yes 29 0.00164930509331545 74 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2698 st077697 67.5 µM 2.9240904963533 0.000969363334395048 yes 30 0.00172732147975988 53 3154499
SGTC_2924 9010168 62.78 µM 2.90188996633344 0.00105052342521782 no 31 0.00185459399524423 91 2993929
SGTC_2718 lomofungin 53.02 µM 2.89810080101908 0.00106498285443644 no 32 0.00187714952656385 53 5351222 A RNA synthesis inhibitor.
SGTC_2722 naftopidil 47.16 µM 2.86926101234025 0.00118115898559541 no 33 0.0020571606143237 50 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_883 0850-0245 24.6 µM 2.86542232784256 0.00119746846098671 no 34 0.00208226711446465 83 6823229 YPR165W RHO1
SGTC_2287 7945887 168.79 µM 2.86011673612305 0.00122034986936721 no 35 0.00211742545219447 46 1245853
SGTC_3050 9093513 49.47 µM 2.85412319368691 0.00124667905924812 no 36 0.00215778963588289 66 25236664
SGTC_856 0433-0016 11.3 µM 2.83149262828147 0.00135084690448531 no 37 0.00231656507749481 56 3911780
SGTC_70 0141-0289 43.283 µM 2.81456658249216 0.00143389038552937 no 38 0.0024421529218745 315 352408
SGTC_740 k014-0057 261 µM 2.80642874436298 0.00147545309247138 no 39 0.00250469951585561 90 4012779
SGTC_1597 7-benzyloxygramine 47.5 µM 2.76219394135467 0.00172122790863069 no 40 0.00287071813339352 263 260807
SGTC_936 3005-4620 401 µM 2.76091828628399 0.00172883873516171 no 41 0.0028819547854209 101 777207
SGTC_1909 st060837 51.5 µM 2.75425820084608 0.00176907391324351 no 42 0.00294126697271714 120 678937
SGTC_2572 astragaloside iv 100 µM 2.66932515186476 0.00236238583945241 no 43 0.00380019167844048 107 45006101 An anti-inflammatory agent.
SGTC_1184 1269-1718 139 µM 2.6645589047559 0.00240049066784146 no 44 0.00385446820631729 82 5403821
SGTC_2438 5259590 200 µM 2.64570161745356 0.00255676298750529 no 45 0.00407608449568611 76 1201127
SGTC_987 1497-1013 404 µM 2.64565826568635 0.00255713260277342 no 46 0.00407660685361381 70 1676435
SGTC_3214 9129694 49.47 µM 2.64045759451288 0.00260182529242641 no 47 0.00413970766130218 98 17158655
SGTC_2719 novobiocin 32.65 µM 2.61350749633685 0.00284492827707168 no 48 0.00448090588435953 36 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_909 3448-9333 149 µM 2.60151770725833 0.00295952282227313 no 49 0.00464061368090507 84 3344074
SGTC_3272 9137413 49.47 µM 2.58382902497158 0.00313618878893213 no 50 0.00488551093840196 94 17614870
SGTC_2285 7945142 200 µM 2.56122827121289 0.00337570416970445 no 51 0.00521513992573371 108 2970608
SGTC_3024 9090631 49.47 µM 2.55211126373518 0.00347688897106427 no 52 0.0053536159766868 60 25236383
SGTC_1293 1000-1278 195 µM 2.51696855325816 0.00389289331315435 no 53 0.00591846967563509 107 678847
SGTC_2943 9068529 45.32 µM 2.51468718967404 0.00392138083009622 no 54 0.00595690190021665 129 3270634
SGTC_875 0709-0210 25.7 µM 2.50797372371115 0.00400629877537801 no 55 0.00607128481651937 124 6251364
SGTC_2967 9089538 49.85 µM 2.5070830353455 0.00401768785341591 no 56 0.00608660554881006 135 728216
SGTC_3324 9138759 60.749 µM 2.50481636763025 0.00404680220317672 no 57 0.00612574913995272 104 45595710
SGTC_440 fluspirilene 35.1 µM 2.49437147763992 0.00418341705935094 no 58 0.00630902062431519 123 3396 An atypical antipsychotic.
SGTC_3053 9095903 49.47 µM 2.48881229151797 0.00425779851181307 no 59 0.00640853082009248 56 17174018
SGTC_607 4491-0986 66.8 µM 2.46601938651806 0.00457527957461648 no 60 0.00683119697463584 125 698981 YDR232W HEM1
SGTC_2265 7929201 200 µM 2.46113738890225 0.00464596767380966 no 61 0.00692486594990005 128 1265108
SGTC_1717 st033143 58.0435 µM 2.45774769518643 0.00469561977818437 no 62 0.00699056798640928 168 674616
SGTC_1172 0370-0043 85 µM 2.44760087918147 0.00484709124806744 no 63 0.00719054304360864 115 376585
SGTC_3049 9092223 49.47 µM 2.44533740637756 0.0048814687201512 no 64 0.00723583422985462 119 8623917
SGTC_2916 7875993 68.79 µM 2.44242909690306 0.00492595881610393 no 65 0.00729439750523888 137 1299250
SGTC_2931 9014674 55.67 µM 2.42487772124391 0.00520220320255017 no 66 0.00765677185860383 137 2996810
SGTC_1526 st051518 75 µM 2.40775001620325 0.00548498311957144 no 67 0.00802558379675678 119 673993
SGTC_464 bw-b 70c 158 µM 2.401825007795 0.00558593886989052 no 68 0.00815675513042279 161 5353454
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.39814737087472 0.00564942881056103 no 69 0.0082391170326502 126 688662
SGTC_3018 9082602 49.47 µM 2.38249602071938 0.00592685346946655 no 70 0.00859785891405978 144 17332089
SGTC_2795 7780010 54.55 µM 2.3788818793523 0.00599260699319709 no 71 0.00868261975507556 144 953673
SGTC_1921 5740136 50 µM 2.37240853707439 0.00611199707758497 no 72 0.00883626899349284 206 1774243
SGTC_1058 3448-5425 97.3 µM 2.35319902193996 0.00647878336635364 no 73 0.00930633451457471 150 7279705
SGTC_11 0438-0307 1.3 µM 2.33650101765194 0.00681329640558678 no 74 0.00973257231402702 121 4011476
SGTC_127 0180-0333 59.125 µM 2.31630021463474 0.00723830662087196 no 75 0.0102709413180788 213 771601
SGTC_3219 9131112 49.47 µM 2.29687767027384 0.00766881510842657 no 76 0.0108128745732511 154 17612988 YMR079W SEC14
SGTC_475 α-linolenic acid 10 µM 2.29327217059517 0.00775116738694091 no 77 0.0109161701938499 161 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.29188266198423 0.00778311195035369 no 78 0.0109562074990964 216 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_979 1426-2828 121 µM 2.28604771875771 0.00791852433475457 no 79 0.0111257335273848 166 747872
SGTC_431 k089-0097 107 µM 2.28511436156597 0.00794037603835401 no 80 0.0111530614570611 216 5499420
SGTC_2190 6049624 200 µM 2.28502340407688 0.00794250836272022 no 81 0.0111557277359164 87 2265554
SGTC_2842 9000675 19.48 µM 2.28338903403654 0.00798090894817815 no 82 0.0112037313174438 156 2989072
SGTC_816 0325-0417 81.3 µM 2.28211810736829 0.00801088292655601 no 83 0.0112411841143659 125 68101
SGTC_2777 climbazole 1.536 µM 2.28067053720637 0.00804514344514663 no 84 0.011283974929779 196 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2778 tioconazole 65.09 nM 2.28062638504047 0.00804619044223795 no 85 0.0112852823092753 218 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.27839876956286 0.00809917043908254 no 86 0.0113514148247414 217 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_624 k048-0052 28 µM 2.27339084492086 0.00821939598348768 no 87 0.0115013186783705 149 6835531
SGTC_1522 st012842 45.6 µM 2.27242310844457 0.00824280839221045 no 88 0.0115304836498413 162 3491067 YOR116C RPO31
SGTC_2033 5192550 145 µM 2.27180331956429 0.00825783367245684 no 89 0.0115491961397258 143 182073
SGTC_1029 k015-0030 64.7 µM 2.26982390076467 0.00830598110298517 no 90 0.0116091349051237 166 2208316
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.26322456064821 0.00846828924003415 no 91 0.0118109249692834 154 75037 A free radical scavenger.
SGTC_381 3461-2219 42.7 µM 2.2629949009361 0.00847398740467738 no 92 0.0118180018083597 156 2883159
SGTC_1578 josamycin 24.2 µM 2.26165363213978 0.00850733333714575 no 93 0.0118594058102373 137 5282165 A P450 substrate.
SGTC_3325 9138760 55.175 µM 2.25278963020191 0.00873061453426309 no 94 0.0121362081715488 166 43844959
SGTC_2739 tacrine 100.86 µM 2.23818588599286 0.00910969300485867 no 95 0.0126044678346511 129 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1026 k007-1105 30.6 µM 2.23635510099228 0.00915821798956569 no 96 0.012664259872848 259 7066794
SGTC_918 glabranin 770.725 nM 2.2337589736478 0.00922741627720925 no 97 0.0127494681636969 175 124049 Also referred to as licorice root.
SGTC_986 1493-0483 84 µM 2.23148369006379 0.00928843849039687 no 98 0.0128245533507611 138 40079
SGTC_2995 9067767 71.4286 µM 2.23140912560279 0.00929044424159729 no 99 0.0128270204644781 134 11673567
SGTC_51 1013-0126 23.419 µM 2.22907972763591 0.0093532951701463 no 100 0.0129043002484023 145 1627850
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.22230296479756 0.00953826309439995 no 101 0.0131314189640937 174 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_278 4092-0821 23.9 µM 2.2196810915311 0.00961067903239549 no 102 0.0132202116363662 176 877900
SGTC_788 1182-0090 188 µM 2.21044683920232 0.00986956875946985 no 103 0.0135370830606066 265 5715185
SGTC_3206 9114350 49.47 µM 2.20281012595518 0.0100882502700205 no 104 0.013804067085595 158 17087243
SGTC_2219 9098279 200 µM 2.19679468170559 0.0102634711056693 no 105 0.0140175565383526 116 902349
SGTC_2487 5918373 44.05 µM 2.19320344329792 0.0103693388110539 no 106 0.0141463622887559 163 2876279
SGTC_1651 st011928 86.1 µM 2.18138054502046 0.0107246258434627 no 107 0.0145776406946585 146 720198
SGTC_2919 7978188 46.38 µM 2.1770925119331 0.0108560791604955 no 108 0.0147368328241862 164 2980291
SGTC_1587 estradiol valerate 56.1 µM 2.15008717817858 0.0117166184560097 no 109 0.0157741598136115 160 13791 A steroid.
SGTC_1315 1237-0019 3.69 µM 2.13195860244302 0.0123269742003853 no 110 0.0165051249580667 162 825140
SGTC_2929 9013348 24.6 µM 2.12959872829616 0.0124084185204238 no 111 0.0166023780715142 191 2995952
SGTC_446 go6976 132 µM 2.12026701421588 0.0127350577135885 no 112 0.0169917668838559 151 3501 A protein kinase C inhibitor.
SGTC_2371 9071574 200 µM 2.11718217010774 0.0128446607964573 no 113 0.017122195008283 144 45596039
SGTC_2334 9017922 200 µM 2.10796189005491 0.0131771302525439 no 114 0.0175171430170077 158 3163164
SGTC_76 0433-0009 400.328 µM 2.10626233142994 0.0132392187332354 no 115 0.0175907857170517 142 2841569
SGTC_3012 9080433 71.4286 µM 2.08940058498525 0.0138690302058787 no 116 0.0183358393100142 174 17688859
SGTC_1371 2421-0008 32.7 µM 2.08324073466065 0.0141054682719809 no 117 0.0186146429062799 247 2827552
SGTC_1150 3909-7983 10.9 µM 2.08219578686389 0.0141459199602287 no 118 0.0186622949800337 224 23965914
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.07425320270363 0.0144566708641478 no 119 0.0190279007522502 218 4174840
SGTC_2998 9066762 71.4286 µM 2.07243344741855 0.0145286899756924 no 120 0.0191125184097606 238 4945196
SGTC_292 k038-0015 474 µM 2.06866322115548 0.0146788845862873 no 121 0.0192888503965429 183 46368540
SGTC_2188 6126565 140.678 µM 2.05934987832655 0.0150556373151006 no 122 0.0197303667650591 147 874518
SGTC_1854 st056233 32.9 µM 2.04943106013302 0.0154659923006336 no 123 0.0202099913235154 193 5393174
SGTC_3285 9112818 20.8695 µM 2.04550216049549 0.0156311711542542 no 124 0.020402688213267 222 17017947 YPR165W RHO1
SGTC_2321 7390090 138.78 µM 2.02870855732308 0.0163543785820857 no 125 0.0212439918918351 201 649046
SGTC_1329 1447-1697 50.6 µM 2.02694221906435 0.0164320845541832 no 126 0.0213341610887531 221 2840515
SGTC_2100 5377183 190 µM 2.01657656900428 0.0168944965191407 no 127 0.0218698601258155 211 2844202
SGTC_2681 menadione 3.18 µM 2.00394990818594 0.0174727641844219 no 128 0.0225377132799614 210 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_653 0203-0016 55.2 µM 2.00146511255563 0.0175885296351114 no 129 0.0226711449149401 222 295302
SGTC_1893 st059353 36.1 µM 1.99995998122559 0.0176589708852804 no 130 0.0227522926869568 221 3112488
SGTC_1031 k035-0009 16 µM 1.98539472011976 0.0183531614409982 no 131 0.0235502864729744 256 5180959
SGTC_1581 himbacine 57.9 µM 1.97992108713509 0.0186199821252169 no 132 0.0238561982605765 267 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1880 MG-132 525 µM 1.97893414088609 0.0186684420674056 no 133 0.0239117108773772 192 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2975 9084847 53.72 µM 1.97194018870282 0.0190149366490338 no 134 0.0243082173902803 251 27211724
SGTC_2450 5739737 12.93 µM 1.96761817164072 0.019231780595227 no 135 0.0245559936558128 210 2262825
SGTC_2757 clomiphene 4.22 µM 1.96633298274074 0.0192966650394593 no 136 0.0246300796271737 268 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2887 9044784 58.44 µM 1.9602455585341 0.0196065297029701 no 137 0.0249835479286402 262 6465546
SGTC_1077 5-fluorocytosine 377 nM 1.95942012322355 0.0196488699232931 no 138 0.025031802958188 211 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1875 nocodazole 6 µM 1.95468928088986 0.0198930360729031 no 139 0.0253098780248958 233 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2472 5377652 49.4 µM 1.95020721474978 0.0201267328276295 no 140 0.0255757131141875 293 1610903
SGTC_1167 k781-0610 148 µM 1.94280192935501 0.0205179479774435 no 141 0.0260200473583661 266 4525169
SGTC_1896 st058441 89 µM 1.94162359899811 0.0205807885426556 no 142 0.026091341929276 206 688759
SGTC_2799 7812892 81.82 µM 1.92794434645351 0.0213223159554266 no 143 0.0269310244732394 255 20205235
SGTC_1560 lithocholic acid 53.1 µM 1.92721660879743 0.02136239024052 no 144 0.0269763204809489 142 9903 A bile acid which acts as a detergent.
SGTC_151 3013-0144 2.285 µM 1.92459276283804 0.0215074065309984 no 145 0.0271401627610415 247 906558 YHR107C CDC12
SGTC_2678 equilin 100 µM 1.9236865488733 0.0215576846368767 no 146 0.0271969425420378 240 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_38 0929-0051 58.268 µM 1.92104961437017 0.0217045510906017 no 147 0.0273627264325037 271 1379719
SGTC_2247 cerulenin 830 nM 1.91828693799969 0.0218593266825269 no 148 0.0275373188760337 237 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1464 k208-0027 110 µM 1.91720308367103 0.0219203023647436 no 149 0.0276060682358258 236 X1464
SGTC_2090 5301565 104.445 µM 1.91705967177245 0.0219283812073813 no 150 0.0276151756243411 278 2056344
SGTC_53 0973-0023 39.979 µM 1.9156497253781 0.0220079418641518 no 151 0.0277048478412144 220 674768
SGTC_1191 1487-1166 10.6 µM 1.91507829846244 0.0220402557493572 no 152 0.0277412594791656 287 3955771
SGTC_1753 st043925 64 µM 1.91418703516711 0.022090736157304 no 153 0.0277981308644521 242 670181
SGTC_198 3454-2873 16.191 µM 1.89856727392595 0.0229913897182141 no 154 0.0288106973440095 243 710957
SGTC_535 2293-4129 48.2 µM 1.89496954862523 0.0232031650141125 no 155 0.0290482180323812 329 396118 YIL048W NEO1
SGTC_2056 5235370 200 µM 1.89430809324361 0.0232422788760921 no 156 0.0290920637000081 274 5511916
SGTC_2601 securinine 100 µM 1.88633924807661 0.0237178788495779 no 157 0.0296246267793781 251 442872 A GABA receptor antagonist.
SGTC_1693 xanthone 101.9 µM 1.88029423513087 0.0240840948617849 no 158 0.0300339942748905 271 7020 An insecticide.
SGTC_2251 lansoprazole 556 µM 1.8734982112948 0.0245014690737778 no 159 0.0304998097573711 200 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1731 st035964 63 µM 1.86765970896483 0.0248648698673495 no 160 0.03090475902164 280 6739575
SGTC_1138 3761-0006 1.03 µM 1.86550925798814 0.0249998526466926 no 161 0.0310550278657919 207 12061087
SGTC_2801 7907800 81.82 µM 1.85569894047088 0.0256234598965043 no 162 0.0317482409624177 279 6620925
SGTC_451 chloral hydrate 100 µM 1.84484086923338 0.0263287997706832 no 163 0.0325303451679018 355 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3234 9132280 49.47 µM 1.83413853566427 0.02703983241914 no 164 0.0333167162121664 276 17612295
SGTC_487 nimodipine 119 µM 1.83246341983519 0.0271525597809763 no 165 0.0334412034370028 173 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2989 9073649 71.4286 µM 1.81746268742741 0.0281796214736138 no 166 0.0345731482993445 371 21367202
SGTC_2083 5306046 65.942 µM 1.81673245976549 0.0282304328060951 no 167 0.0346290444811107 318 539837
SGTC_2688 kanamycin b 96.69 µM 1.81078316118249 0.0286472502907895 no 168 0.0350872119419996 850 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1692 fluoroquinolonic acid 71 µM 1.80654987036601 0.0289469478193343 no 169 0.0354162458536845 235 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1227 3909-8010 46.6 µM 1.79807412219024 0.0295548259308802 no 170 0.0360826312253372 278 15982272
SGTC_152 4469-0003 551.229 µM 1.76440952964398 0.0320747722010139 no 171 0.0388315274492916 282 697280
SGTC_2724 maprotiline 69.64 µM 1.76267229157534 0.0322094845578577 no 172 0.0389778883178681 262 4011 A tricyclic antidepressant.
SGTC_2340 7987427 183.45 µM 1.76227366546255 0.0322404613983583 no 173 0.0390115355197024 292 2239331
SGTC_1313 1220-0047 237 µM 1.75780958076322 0.0325890434426526 no 174 0.0393899573130097 372 3528706
SGTC_2515 chrysin 20.77 µM 1.75675610901646 0.0326717564796521 no 175 0.0394796946099704 265 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1305 1181-0477 144 µM 1.75438421843884 0.0328586185717468 no 176 0.039682346824965 280 6252086
SGTC_1091 telmisartan 47.6 µM 1.75265305718928 0.0329955581958904 no 177 0.0398307890201025 298 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2225 6654152 15.4 µM 1.75153919405749 0.0330839162356846 no 178 0.0399265380702689 218 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1655 st012546 55.1 µM 1.75027746096646 0.0331842395674963 no 179 0.0400352240866889 288 720985 YLR208W SEC13
SGTC_1681 tripelennamine 100 µM 1.74867226854909 0.0333122342270351 no 180 0.0401738431267382 253 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3044 9093193 49.47 µM 1.74100848897146 0.0339289441289613 no 181 0.0408410452643325 348 25236277
SGTC_1428 4049-0204 61.7 µM 1.74082473205261 0.0339438456911483 no 182 0.0408571526827682 297 X1428
SGTC_686 1319-0111 510 µM 1.73791028599245 0.034180910010384 no 183 0.0411133114835714 315 4562600
SGTC_3074 9116018 49.47 µM 1.73665809434001 0.0342831818749536 no 184 0.0412237693376253 267 17027303
SGTC_2273 7815444 169.05 µM 1.7323807576637 0.0346344288154259 no 185 0.0416028958675292 307 2824616
SGTC_402 epigallocatechin gallate 10 µM 1.73235040711277 0.0346369316673562 no 186 0.0416055960811293 332 65064 An antioxidant.
SGTC_627 1391-0720 175 µM 1.7259636188157 0.0351669310809429 no 187 0.0421769790414244 306 997839
SGTC_1995 st072814 61.1 µM 1.71723408516271 0.0359020842989176 no 188 0.0429682050305155 300 5769371
SGTC_868 0527-0199 213 µM 1.716402178448 0.0359727951907985 no 189 0.0430442290690591 325 2849450
SGTC_2544 sphondin 68.51 µM 1.71388645580492 0.0361873224174558 no 190 0.0432747905001003 292 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2415 st077333 57.7 µM 1.71118119670244 0.0364191799611478 no 191 0.043523834347846 404 2766255
SGTC_162 k030-0015 37.8 µM 1.70869160587217 0.0366336262657616 no 192 0.0437540449073382 294 1809920 YMR134W ERG29
SGTC_2093 5331342 194.4 µM 1.69859956843124 0.0375135305526756 no 193 0.0446973289192575 324 33839
SGTC_1831 st055328 12 µM 1.69744072843367 0.0376156629823439 no 194 0.0448066839926122 328 1103068
SGTC_2818 7996756 12.99 µM 1.69307191008123 0.0380027445650001 no 195 0.0452208901500412 237 2241621
SGTC_604 1000-0114 314 µM 1.6870028291983 0.038545857551036 no 196 0.0458014039731038 345 1572745
SGTC_1112 tnp00069 1.16933 µM 1.68154600277244 0.0390395656274947 no 197 0.046328454410498 372 145826
SGTC_3010 9080089 71.4286 µM 1.68128209163772 0.039063572988141 no 198 0.0463540673406638 324 17027233
SGTC_1625 st003711 30.1 µM 1.68108978946527 0.0390810738224385 no 199 0.0463727376837925 320 24207034 YER133W GLC7
SGTC_2024 5144227 134 µM 1.67802023554929 0.039361289646359 no 200 0.0466715743590128 374 3475211
SGTC_3102 9121669 49.47 µM 1.67769303600549 0.0393912554672949 no 201 0.0467035198243328 270 41905072
SGTC_1354 1498-1681 81 µM 1.67122099206493 0.0399878067514065 no 202 0.0473390176804599 354 5754243
SGTC_670 4204-0025 119 µM 1.66288436636686 0.0407670202478001 no 203 0.04816779219556 361 719039
SGTC_1745 st081495 74 µM 1.66028886205759 0.0410121184809597 no 204 0.0484281776469006 425 13842402 YBL026W LSM2
SGTC_1181 1222-0449 220 µM 1.65669283969396 0.0413536710189331 no 205 0.0487907956957965 340 658318
SGTC_3178 9107506 49.47 µM 1.65415020103256 0.0415965610567827 no 206 0.0490484991172462 342 8897194
SGTC_2986 9022445 71.43 µM 1.65127324823345 0.041872779344782 no 207 0.0493413961135266 340 6459286
SGTC_1568 digitonin 820 nM 1.64592954297213 0.0423897724791614 no 208 0.0498891328646898 381 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_731 3966-0296 387 µM 1.64584867135992 0.0423976361344072 no 209 0.0498974594117647 337 660956
SGTC_1320 1313-0481 95.3 µM 1.64345107295725 0.0426313062456317 no 210 0.0501448202425333 335 6813365 YLR208W SEC13
SGTC_1816 st051957 91.6 µM 1.64085787779112 0.0428852102225374 no 211 0.050413460279501 327 674121
SGTC_3228 9131799 49.47 µM 1.63962204232919 0.0430066421349502 no 212 0.0505418885469907 322 17015818
SGTC_208 k072-0098 12.366 µM 1.63643692241376 0.043320889679537 no 213 0.0508740885157263 438 5948901
SGTC_1819 st053448 58.6 µM 1.63529707274704 0.0434337980158986 no 214 0.050993393463551 332 2857616
SGTC_1716 st033144 30.6155 µM 1.62904655532171 0.0440571756762275 no 215 0.0516515819129842 358 674617
SGTC_1712 st032288 53.4 µM 1.62464508427881 0.0445004573899801 no 216 0.0521191024266299 579 2883011
SGTC_1501 4491-0275 38.4 µM 1.62241711336392 0.0447262071028783 no 217 0.0523570336697115 326 5104718
SGTC_2603 homopterocarpin 100 µM 1.61751490680227 0.0452261717505152 no 218 0.0528835902852867 408 101795 A weak amylase inhibitor.
SGTC_546 peri-Naphthalide 147 µM 1.61647863850758 0.0453324319190241 no 219 0.0529954341259578 360 223824 A penicillin ester.
SGTC_3089 9117425 49.47 µM 1.61233365916825 0.0457594726693589 no 220 0.0534446762944349 363 9401657
SGTC_1571 st070080 73.4 µM 1.60649154203908 0.04636684640353 no 221 0.0540829759170163 362 4315245
SGTC_3067 9117431 49.47 µM 1.60496122595498 0.0465270103426683 no 222 0.0542511689952407 313 17150885
SGTC_2354 9060492 162 µM 1.60348358865233 0.0466820819534272 no 223 0.0544139647729683 392 6471895
SGTC_2011 4012611 177 µM 1.60345777520739 0.0466847946432155 no 224 0.0544168121488619 379 2049887
SGTC_1888 azatryptophan 97.5 µM 1.6029648849217 0.046736615889353 no 225 0.0544712034808824 307 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2627 acetyl isogambogic acid 100 µM 1.60247282583222 0.0467883957675535 no 226 0.0545255459710039 357 6857789 A caspase activator and apoptosis inducer.
SGTC_397 arbidol 50 µM 1.60228103701794 0.0468085903593538 no 227 0.054546738535631 387 131410 A RNA synthesis inhibitor.
SGTC_2837 9008476 45.46 µM 1.59737613666429 0.0473274367379263 no 228 0.0550909442533329 403 2992805
SGTC_2173 5763948 167 µM 1.58593515677473 0.0485555964839682 no 229 0.0563770098306908 384 2867177
SGTC_2432 5630864 12.22 µM 1.57967311943435 0.0492385240606992 no 230 0.0570908722982333 378 5714970
SGTC_3027 9089541 49.47 µM 1.57827253927162 0.0493923137970953 no 231 0.0572515058705337 409 9943819
SGTC_1088 bifonazole 369 nM 1.57684919511625 0.0495489957381015 no 232 0.0574151144506416 349 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1197 1601-0112 267 µM 1.57464676114929 0.0497922215080486 no 233 0.0576690014535623 407 7350313
SGTC_2060 5238662 140 µM 1.57387926451525 0.0498772034310533 no 234 0.0577576822690119 377 790130
SGTC_1739 st037196 92.5 µM 1.56939102024441 0.0503764880654103 no 235 0.0582784275736454 395 612214
SGTC_3167 9103034 49.47 µM 1.56668698252928 0.0506792100437268 no 236 0.0585939374992015 282 5127859
SGTC_3038 9091290 49.47 µM 1.56643797827504 0.0507071592210201 no 237 0.0586230588744649 380 25236843
SGTC_3312 9133330 71.43 µM 1.56427064509393 0.0509509475930158 no 238 0.058877011422819 384 17617324
SGTC_2347 9049783 174.81 µM 1.56270711045765 0.0511273974563588 no 239 0.0590607505947627 430 6467988 YPL169C MEX67
SGTC_1979 st071809 45.3 µM 1.55962047592752 0.0514771613187432 no 240 0.0594247974091285 375 4976333
SGTC_864 0469-0573 172 µM 1.55899299019759 0.0515484974474098 no 241 0.0594990196372731 372 689425
SGTC_976 1348-1067 47.6 µM 1.55599018198622 0.0518909624615066 no 242 0.0598552135147823 442 5310671 YGL099W LSG1
SGTC_185 k048-0037 25.491 µM 1.55356452736796 0.0521689221789179 no 243 0.0601441630966168 389 6827589
SGTC_2650 prasterone 100 µM 1.54841843508489 0.0527625365968636 no 244 0.0607607927807778 266 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3172 9105863 49.47 µM 1.54832194296924 0.0527737181719993 no 245 0.0607724019780019 258 2348785
SGTC_3078 9116413 49.47 µM 1.54586921066578 0.05305857430127 no 246 0.0610680788951922 360 17177322
SGTC_2703 st077852 53.4 µM 1.54473173747914 0.053191091659648 no 247 0.0612055823912138 390 6281836
SGTC_1755 st041960 45.185 µM 1.54403292111445 0.0532726348589746 no 248 0.0612901787395427 385 2257073
SGTC_1853 st056710 91.2 µM 1.5380539111975 0.0539743681722322 no 249 0.0620177168454149 402 269167
SGTC_1422 4031-0024 15.5 µM 1.53592976458223 0.0542254255093815 no 250 0.0622778035815565 392 782427
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.53472499745731 0.0543682296032525 no 251 0.0624256964330757 446 5379071
SGTC_2794 7785382 27.27 µM 1.53288957891642 0.0545863580880576 no 252 0.0626515319832167 491 2205081
SGTC_366 0181-0206 4.31 µM 1.53278077670846 0.0545993102741257 no 253 0.0626649393089524 443 274874
SGTC_1129 3453-1384 223 µM 1.53084668334882 0.0548299571501608 no 254 0.0629036444265516 446 1084452
SGTC_2374 9071832 200 µM 1.52953284405689 0.0549870755114917 no 255 0.0630662016515977 366 17381698
SGTC_1090 efavirenz 20.7 µM 1.52737662540572 0.0552457024791833 no 256 0.0633336927074374 391 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.52569394086524 0.055448198218305 no 257 0.0635430521040631 455 688664
SGTC_3330 9141424 71.43 µM 1.52525740134026 0.0555008273888698 no 258 0.0635974541839703 447 27261020
SGTC_2653 dihydrofissinolide 100 µM 1.52470803914564 0.0555671144842804 no 259 0.0636659678544302 348 6857746
SGTC_1414 3917-0015 5.4 µM 1.52070572112289 0.0560519297643732 no 260 0.0641668511862979 362 6618702
SGTC_251 melphalan 456.522 µM 1.52019402624517 0.0561141530092909 no 261 0.064231109176512 470 460612 A DNA alkylator.
SGTC_841 0251-0215 91.2 µM 1.51480602918828 0.0567726568067874 no 262 0.0649107665895814 489 3888614
SGTC_1187 1391-0724 117 µM 1.51433046993596 0.0568310692467563 no 263 0.0649710221268165 454 6997986
SGTC_3356 9151811 4.48 µM 1.50887389950476 0.0575046863090845 no 264 0.0656655055017189 400 1859254 YPR165W RHO1
SGTC_1328 1441-0025 69.2 µM 1.50342672910911 0.0581833915359753 no 265 0.0663645191096636 364 4562601
SGTC_333 3486-0131 40.1 µM 1.50174126318217 0.0583946669434992 no 266 0.0665819714283366 404 6744690
SGTC_2218 6965428 192.983 µM 1.50134374391978 0.0584445842182143 no 267 0.0666333381190523 402 675684
SGTC_2356 9061756 188.97 µM 1.49755167021414 0.0589224484240371 no 268 0.0671248857292164 382 20104043
SGTC_1143 3454-2408 5.08 µM 1.49539727422665 0.0591953005305309 no 269 0.0674053957537776 346 X1143
SGTC_2409 alverine citrate 63.97 µM 1.49497984756574 0.0592482816152238 no 270 0.0674598508220262 447 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1230 0170-0365 3.77 µM 1.49151871979018 0.0596890122129196 no 271 0.0679126800755637 576 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2952 9073731 13.78 µM 1.49087323469263 0.0597714900208198 no 272 0.0679973898410587 467 16457353
SGTC_2349 9023730 187.07 µM 1.4905169868262 0.0598170483377696 no 273 0.0680441766947401 429 4126287
SGTC_390 dec-rvkr-cmk 16.7 µM 1.49018143260747 0.0598599851469827 no 274 0.0680882685306332 438 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1149 3909-7961 23.3 µM 1.49006175148325 0.0598753051303754 no 275 0.0681039999696583 413 735261
SGTC_2394 5221648 200 µM 1.47889095008306 0.0613188116346013 no 276 0.0695847312341947 495 788586
SGTC_25 0118-0223 35.662 µM 1.47477896114014 0.0618569634739536 no 277 0.0701359896392746 435 5333628
SGTC_973 1325-0077 65.9 µM 1.47280276943351 0.0621169034390042 no 278 0.0704021126880867 464 2835149
SGTC_404 fumagillin 50 µM 1.47107552894585 0.0623447946380073 no 279 0.0706353460492692 471 12015870 A methionine aminopeptidase binder.
SGTC_2085 5307070 144.047 µM 1.47107071103427 0.0623454312213757 no 280 0.0706359974527501 389 2840351
SGTC_3039 9090270 49.47 µM 1.46987562370985 0.0625034929341895 no 281 0.0707977213275642 394 17173750
SGTC_3270 9137563 49.47 µM 1.46792003667323 0.0627628116725166 no 282 0.0710629724304321 376 17015724
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.46552187140766 0.0630819616705966 no 283 0.0713892948192512 409 2374 Ca(2+)-ATPase inhibitor.
SGTC_1368 1852-0141 284 µM 1.4565526375539 0.0642868095093169 no 284 0.0726199548069895 448 2838987
SGTC_1483 3453-0561 55.9 µM 1.4563194906358 0.0643183652487341 no 285 0.0726521599857136 493 4546991
SGTC_1427 4048-4900 550 nM 1.45327039602266 0.0647321600466072 no 286 0.0730743467194151 442 24132586
SGTC_2896 9052656 71.43 µM 1.45315149743004 0.0647483376406731 no 287 0.0730908477263692 594 6469436
SGTC_1176 0848-0131 83.3 µM 1.45224198054149 0.0648721923164957 no 288 0.0732171668161381 501 6769040
SGTC_1611 st001856 99.4 µM 1.44807631543066 0.0654418090952565 no 289 0.0737978543004315 430 647478
SGTC_2875 9039966 71.43 µM 1.44806369983272 0.0654435400361593 no 290 0.0737996182265496 381 6463691
SGTC_1206 3978-0017 132 µM 1.44501667897572 0.0658626517946651 no 291 0.0742266003956006 432 3873677
SGTC_1302 1159-0335 255 µM 1.43359219590031 0.0674526085196569 no 292 0.0758443359302767 436 649284
SGTC_1531 st059297 52.4 µM 1.43284020270246 0.06755829576394 no 293 0.0759517546464746 460 7566702
SGTC_1101 ebselen 5.29 µM 1.43139909942352 0.0677611899911994 no 294 0.0761579331829586 473 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1258 0671-0043 57.1 µM 1.42967684671935 0.0680042844942449 no 295 0.0764048942187953 476 4298767
SGTC_932 2857-0803 154 µM 1.42735241210293 0.0683334434409651 no 296 0.0767391701491065 494 674898
SGTC_639 0833-0042 114 µM 1.42375188987015 0.0688457321198423 no 297 0.0772591534697308 499 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_560 2332-1943 155 µM 1.42023273359791 0.069349300240386 no 298 0.0777699684604991 449 21177716
SGTC_2308 7584454 197.62 µM 1.41981962122322 0.0694085995017095 no 299 0.0778301005690747 530 893577
SGTC_1813 st051246 8.6015 µM 1.41921142603672 0.0694959725352404 no 300 0.077918692889985 417 5291959
SGTC_2552 juarezic acid 87.02 µM 1.41746472341755 0.0697473739517988 no 301 0.0781735505568641 542 1549512
SGTC_2721 ifenprodil 61.44 µM 1.41592899953359 0.0699689871706623 no 302 0.0783981466621749 458 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_742 0kpi-0133 140 µM 1.41551109852288 0.0700293862131772 no 303 0.078459348329529 484 2728852
SGTC_1963 st076565 50.3 µM 1.40507232312634 0.0715511475398379 no 304 0.0799998865949795 472 4914280
SGTC_2883 9059145 45.46 µM 1.40096994320843 0.0721560893176545 no 305 0.080611530676947 436 16476510
SGTC_320 4092-0846 5.34 µM 1.40090714499583 0.0721653799870006 no 306 0.0806209209434656 473 1359356
SGTC_861 0443-0273 110 µM 1.40038527066976 0.0722426240576379 no 307 0.080698989188633 475 6149169
SGTC_534 k292-0788 63.4 µM 1.39990872861681 0.0723132137054909 no 308 0.0807703259397886 534 4146317
SGTC_1267 0828-0272 9.49 µM 1.39927125620712 0.0724077244161473 no 309 0.0808658278650207 524 745334
SGTC_1288 0973-0013 65.5 µM 1.39916451940533 0.072423558300904 no 310 0.0808818267995209 500 4315430
SGTC_374 0880-0231 82.3 µM 1.39894518846668 0.0724561033036149 no 311 0.0809147101330966 491 6833587
SGTC_2539 epi(13)torulosol 80 µM 1.39707339763882 0.0727343013793427 no 312 0.0811957502792311 470 6708597
SGTC_2458 5808907 16.39 µM 1.39283480033886 0.0733672924225073 no 313 0.0818348761230883 486 2731747
SGTC_2568 diosmetin 100 µM 1.39212327096582 0.073473963830038 no 314 0.0819425362459329 507 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_712 r015-0009 80.6 µM 1.39061159220082 0.0737009860432408 no 315 0.0821716196090134 432 6813872 YLR060W FRS1
SGTC_3045 9092950 49.47 µM 1.3797353031952 0.0753502114254998 no 316 0.0838340794775979 537 44120432
SGTC_3079 9117512 49.47 µM 1.37904779050704 0.0754554001235422 no 317 0.0839400097690207 475 7185044
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.37769572460817 0.0756625911398695 no 318 0.0841486259651315 535 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_685 1278-0033 54.9 µM 1.37516017369891 0.0760523079040879 no 319 0.0845408961974489 526 3590572
SGTC_2594 a-mangostin 100 µM 1.37385887086103 0.076252911969105 no 320 0.084742750172602 538 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1271 0832-2808 169 µM 1.3734341531043 0.0763184719867459 no 321 0.0848087092130446 509 3663794
SGTC_968 1309-0633 340 µM 1.37302741117886 0.0763812974295583 no 322 0.0848719126686463 490 3761976
SGTC_2302 7771753 200 µM 1.37067295474711 0.0767457406696107 no 323 0.0852384646611648 543 2203047
SGTC_2470 5664817 21.68 µM 1.36961087633553 0.0769105705137988 no 324 0.085404201315108 467 2859561
SGTC_2465 5809242 33.21 µM 1.36340016344815 0.0778798379391897 no 325 0.0863782148092012 452 2731748
SGTC_2021 4019055 173 µM 1.36291134099998 0.0779565171746528 no 326 0.0864552270210557 674 44827708 YER133W GLC7
SGTC_2596 sinensetin 100 µM 1.36085779328203 0.0782792733058928 no 327 0.0867793169385346 479 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_350 k064-0020 19.8 µM 1.35892268220427 0.0785843411904423 no 328 0.0870855452312133 541 2790705
SGTC_2815 7968870 71.43 µM 1.35672151306166 0.0789324473456398 no 329 0.0874348571032634 551 2977326 YHR190W ERG9
SGTC_1498 4478-3555 97.6 µM 1.35660586788627 0.0789507684152706 no 330 0.0874532381479444 434 3437919
SGTC_1386 3228-0095 33.8 µM 1.35084785455144 0.0798670593470617 no 331 0.0883720875125284 485 870181
SGTC_39 0986-0283 58.349 µM 1.34408725814194 0.0809531329864573 no 332 0.0894600859636902 590 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_659 k018-0002 107 µM 1.34390398422532 0.0809827299445269 no 333 0.0894897187442202 523 6797879 YHR007C ERG11
SGTC_420 mitomycin C 81.9 mM 1.34357243887772 0.081036292050039 no 334 0.0895433434491814 528 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3189 9110682 49.47 µM 1.33948867683355 0.0816982301404267 no 335 0.0902058191080565 514 17122418
SGTC_1410 3909-8106 77.9 µM 1.33924171138383 0.0817383911593064 no 336 0.0902459987462377 499 1039210
SGTC_1467 k284-1082 293 µM 1.3301450241226 0.0832280663536732 no 337 0.0917352467216331 548 3334705
SGTC_124 0136-0217 7.121 µM 1.32929442896769 0.0833683968388225 no 338 0.0918754257670125 614 3976905
SGTC_1607 st000305 50.6 µM 1.3283925054257 0.0835173896385037 no 339 0.0920242370229211 532 5457690
SGTC_3216 9129716 49.47 µM 1.32814276964212 0.0835586799669717 no 340 0.0920654732638391 495 8056934
SGTC_2074 5212007 75.395 µM 1.32500718356197 0.084078411498802 no 341 0.0925843843634463 443 758611
SGTC_1314 1222-0010 41.1 µM 1.32310359470629 0.0843951180622083 no 342 0.0929004647277436 511 3526027
SGTC_2999 9069765 71.4286 µM 1.31802683443775 0.0852441320821817 no 343 0.0937473325406289 556 2097066
SGTC_2457 5731572 11.68 µM 1.31784905624575 0.0852739784357407 no 344 0.0937770911331586 520 2865357
SGTC_2279 7948423 32.93 µM 1.31758377327252 0.0853185301168977 no 345 0.0938215102649951 480 1247112
SGTC_2174 5790901 200 µM 1.31457329333331 0.0858253331198384 no 346 0.0943266753028929 516 786020
SGTC_245 methotrexate 289.6 µM 1.31290051518988 0.0861079111656538 no 347 0.0946082366369416 584 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2581 avocatin a 64 µM 1.31169639916115 0.0863117497795702 no 348 0.0948112961046819 584 6710728 A skin care supplement.
SGTC_79 0052-0007 94.094 µM 1.31089847443462 0.0864470250167383 no 349 0.0949460331770575 551 2801472
SGTC_3034 9090421 49.47 µM 1.31017844340835 0.0865692306416287 no 350 0.0950677381984141 476 17173761
SGTC_3343 9148379 18.9835 µM 1.30879566539741 0.0868042815490574 no 351 0.095301787821419 538 1955036
SGTC_2888 9058547 12.99 µM 1.30697012070034 0.0871153258893428 no 352 0.0956114297064498 448 16476514
SGTC_971 1315-0384 26.7 µM 1.30693437965334 0.0871214239030106 no 353 0.0956174993457434 542 6769120
SGTC_2479 5617353 43.85 µM 1.30534027842653 0.0873937282181045 no 354 0.0958885022513517 539 2731746
SGTC_1627 st003713 25.6 µM 1.30352830423473 0.0877040204948633 no 355 0.0961972298703174 630 16195070 YER133W GLC7
SGTC_2580 diallyl disulphide 81.36 µM 1.30098897204858 0.0881402514981311 no 356 0.0966311147653303 517 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2907 7721985 69.9 µM 1.300442238353 0.0882343859533576 no 357 0.096724720604993 528 3267881
SGTC_2335 9018011 154.17 µM 1.29964409996929 0.0883719407927306 no 358 0.0968614887828137 588 6458208
SGTC_2662 daunorubicin 22.37 µM 1.29356486218456 0.0894249125087961 no 359 0.097907883077442 502 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1810 st050138 53 µM 1.28473054369777 0.0909716795816243 no 360 0.099443230491979 495 3444541
SGTC_634 1611-4317 11.2 µM 1.28123164774984 0.0915897442515103 no 361 0.100056156549436 606 2843522
SGTC_3247 9135149 49.47 µM 1.28103940673735 0.0916237927447715 no 362 0.100089912516595 496 8934436 YOR116C RPO31
SGTC_2831 7999036 19.48 µM 1.27981132988243 0.0918415231863107 no 363 0.10030574911602 584 2988270
SGTC_3065 9113888 49.47 µM 1.26705579272317 0.0941257033619839 no 364 0.102567670513091 519 16648368
SGTC_2216 7189485 200 µM 1.265745965664 0.0943626109819777 no 365 0.102802022993407 562 731273
SGTC_1142 3253-1408 9.78 µM 1.26494149598024 0.0945083327293077 no 366 0.102946150358264 558 256655
SGTC_1579 chlormadinone acetate 49.4 µM 1.26364435313348 0.094743646685893 no 367 0.103178853256196 583 45114258 A steroidal progestin.
SGTC_603 3794-0023 45.9 µM 1.26293130114273 0.094873184824848 no 368 0.103306934880221 549 3802260
SGTC_111 0083-0039 52.457 µM 1.26270353796216 0.0949145894038489 no 369 0.103347871047505 411 759313
SGTC_47 0149-0135 24.25 µM 1.26244926860442 0.0949608282090234 no 370 0.10339358511394 539 5239155
SGTC_2806 7952793 58.44 µM 1.26244096442636 0.0949623386010511 no 371 0.103395078336236 575 2972490
SGTC_1392 3455-1037 33.9 µM 1.26210068957805 0.0950242441640443 no 372 0.103456278588884 578 981132
SGTC_3135 9127742 49.47 µM 1.26157998826317 0.0951190319151116 no 373 0.103549980401917 535 3643468
SGTC_3054 9094397 49.47 µM 1.26090348892135 0.0952422849068277 no 374 0.103671810518972 597 2598354
SGTC_1706 st031321 9.9705 µM 1.25687240893455 0.0959791556255669 no 375 0.104399920445373 578 6103185
SGTC_1751 st044839 27.194 µM 1.25315289068739 0.0966627847619727 no 376 0.105075035318042 554 5291326
SGTC_1746 st038117 42 µM 1.25270388726417 0.096745550701135 no 377 0.105156745384722 591 2898218
SGTC_372 0155-0182 15.9 µM 1.25165339235757 0.096939394389902 no 378 0.105348095055553 638 771486
SGTC_1124 fisetin 1.16336 µM 1.24870296683811 0.0974853495786903 no 379 0.105886867668448 528 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2705 st078069 42.8 µM 1.2483839438516 0.0975445173448466 no 380 0.105945243049723 546 1530061
SGTC_1120 ficusin 1.78878 µM 1.24832550391542 0.0975553587918622 no 381 0.105955939010827 595 6199 A DNA cross-linker.
SGTC_845 0330-0138 4.51 µM 1.24688154283393 0.0978235150244211 no 382 0.106220467672353 580 9039800
SGTC_171 k064-0041 9.68 µM 1.24553882936048 0.0980733531295969 no 383 0.106466875850096 479 53325
SGTC_2032 5185112 25.99 µM 1.24440730993791 0.0982842571874664 no 384 0.106674846955623 541 5718189
SGTC_183 3914-0051 30.55 µM 1.24382489894445 0.0983929422584015 no 385 0.106782007208738 580 1596232
SGTC_31 0508-1974 57.237 µM 1.24349898452347 0.0984538002994019 no 386 0.106842007462474 567 6810525
SGTC_18 0111-0177 500 nM 1.24020844343964 0.0990697879498107 no 387 0.107449153093348 699 721752
SGTC_1675 st018485 24.5 µM 1.23899355997579 0.0992979245668154 no 388 0.107673941515706 587 3323024
SGTC_704 1310-0270 142 µM 1.23544534554637 0.0999664238838218 no 389 0.108332402675341 613 5718033
SGTC_3084 9116877 49.47 µM 1.23503221368402 0.100044472864855 no 390 0.108409257701536 516 27241325
SGTC_2519 cryptotanshinone 88.04 µM 1.23472052025779 0.100103387511392 no 391 0.108467268069036 573 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3248 9135562 49.47 µM 1.23391517732163 0.100255726448702 no 392 0.10861725668526 648 17650701
SGTC_1134 3477-0009 42.5 µM 1.23103519642008 0.100801889108666 no 393 0.109154850371466 647 3973534
SGTC_3352 9151559 45.5865 µM 1.22841329690073 0.101300992792383 no 394 0.109645929412014 571 17159339
SGTC_3016 9080866 49.47 µM 1.22657617416192 0.101651777875024 no 395 0.109990964381585 629 17066299
SGTC_426 0988-0037 14.6 µM 1.22528417528391 0.101899004745225 no 396 0.110234084326262 661 5383008
SGTC_1454 4239-0054 42.6 µM 1.22278985065095 0.102377536749232 no 397 0.11070453992056 652 1340767
SGTC_3342 9147791 14.508 µM 1.22241813385425 0.102448989679957 no 398 0.110774772582585 610 1838168
SGTC_1208 2323-2347 50.3 µM 1.21901767649935 0.103104323230113 no 399 0.111418741730919 619 5412760
SGTC_3254 9136651 49.47 µM 1.2177914925471 0.103341377742541 no 400 0.111651609034596 630 16454030
SGTC_1355 1499-0035 1.68 µM 1.21693175216926 0.103507824615719 no 401 0.111815091751752 582 1548538
SGTC_288 1315-0019 35.1 µM 1.21400386501161 0.104076126884319 no 402 0.112373124124139 635 6811474
SGTC_764 1951-2361 146 µM 1.20994826554922 0.104867050049535 no 403 0.113149372534381 618 5438930
SGTC_538 2922-0838 53.3 µM 1.2040909052182 0.106017020294775 no 404 0.114277222377976 693 777039
SGTC_568 1193-0097 7.48 µM 1.20334977742727 0.106163172153272 no 405 0.114420496998928 632 3646150
SGTC_967 1306-0166 352 µM 1.20184105350569 0.106461145089494 no 406 0.114712558129007 615 4437607
SGTC_1139 k015-0024 46.9 µM 1.20172994135761 0.106483113584852 no 407 0.114734088344288 615 2766652
SGTC_1132 3456-3614 2.5 µM 1.19859969554213 0.107103354378884 no 408 0.115341818321336 725 3125502
SGTC_69 0096-0274 206.684 µM 1.19813013089011 0.107196620283479 no 409 0.115433180192904 693 6741392
SGTC_3300 9124615 50.48 µM 1.19797954217995 0.107226542923644 no 410 0.115462490701837 607 24824903
SGTC_2414 st077232 92.9 µM 1.19796278209809 0.107229873598155 no 411 0.115465753202556 594 729801
SGTC_3337 9144342 33.5465 µM 1.19770143353687 0.107281820166993 no 412 0.115516635526284 629 17682949
SGTC_2838 9002687 71.43 µM 1.19631032370627 0.10755862741784 no 413 0.115787740773553 576 6457060
SGTC_430 0958-0115 16.4 µM 1.18706789335441 0.109410789586401 no 414 0.117600420699992 613 6833180
SGTC_1382 3002-2117 298 µM 1.18693170694916 0.109438251240807 no 415 0.117627279721965 671 1497314
SGTC_2513 baicalein 25.65 µM 1.18527081566433 0.109773564305107 no 416 0.117955194275968 634 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_554 4483-2211 187 µM 1.18338247560045 0.110155691529544 no 417 0.118328799681084 613 747107
SGTC_1701 st028638 40.4 µM 1.17821386953433 0.111206495766275 no 418 0.119355677316208 637 3490878
SGTC_3132 9126706 49.47 µM 1.17733039281031 0.111386826984499 no 419 0.119531830297454 604 850858
SGTC_719 2810-4230 27.3 µM 1.17708534429858 0.111436882220967 no 420 0.119580722038277 597 721079
SGTC_2640 pentamidine 10.38 µM 1.1765591317181 0.11154442429527 no 421 0.119685758911051 700 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1510 1123-0200 71.5 µM 1.17650984274341 0.111554501286364 no 422 0.11969560077566 721 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_702 1488-0190 94 µM 1.17649367328053 0.11155780722909 no 423 0.11969882956655 643 949357
SGTC_1119 parthenolide 318.541 nM 1.1762194750782 0.111613879354502 no 424 0.119753592046348 713 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_192 3455-0609 60.9 µM 1.17055385639759 0.112776984891615 no 425 0.120889077119322 633 3769639
SGTC_2908 7930301 100 µM 1.16935472128711 0.11302426326079 no 426 0.121130372252813 722 2223178
SGTC_2683 piperine 63.03 µM 1.16915172413534 0.113066162370154 no 427 0.121171253721264 624 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2001 4023502 57.655 µM 1.16815209451787 0.113272650057123 no 428 0.121372710058103 650 108941 YCR052W RSC6
SGTC_2353 9059630 146.67 µM 1.1657262463032 0.113774861594202 no 429 0.121862572471766 629 4779114
SGTC_443 clozapine 122 µM 1.16531307294897 0.113860556783752 no 430 0.121946144650935 565 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_227 fluconazole 33.516 µM 1.16330852251463 0.11427696818261 no 431 0.122352174550769 686 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1559 coumarin 343 70.1 µM 1.16280545814893 0.11438164129753 no 432 0.122454221073518 606 108770 A hepatotoxic, DNA x-linker.
SGTC_602 3130-1533 38.1 µM 1.16153453742433 0.11464638707769 no 433 0.122712293130175 713 720941
SGTC_2325 6158266 200 µM 1.1610972483009 0.114737579625776 no 434 0.122801176828437 620 3623240
SGTC_2393 9031399 185.94 µM 1.15750198657701 0.115489294638194 no 435 0.123533664067933 644 1526623 YDL150W RPC53
SGTC_1020 4335-0961 93.3 µM 1.14992249403244 0.117085501785753 no 436 0.125087897638248 611 669075
SGTC_2695 st077686 51.995 µM 1.14624512560678 0.117865545549145 no 437 0.125846870561468 624 2876092
SGTC_1070 indatraline 8.81 µM 1.14581462944983 0.117957102296173 no 438 0.125935930323333 658 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_254 nsc-64875 3.808 µM 1.14326050071958 0.118501342222993 no 439 0.126465224761451 658 56993
SGTC_2337 9009472 200 µM 1.14319643074281 0.118515017188067 no 440 0.126478521937391 711 5742383
SGTC_1275 0867-0008 21.1 µM 1.14288786141364 0.118580893215937 no 441 0.126542576505204 670 3422836
SGTC_3153 9100258 49.47 µM 1.14275410840833 0.11860945599238 no 442 0.126570348730199 601 25236848
SGTC_710 3448-4187 58 µM 1.1399606603079 0.119207104414676 no 443 0.127151345510878 756 3946412
SGTC_713 1488-1073 324 µM 1.13882569275936 0.119450532984764 no 444 0.12738793166162 684 3312542
SGTC_1556 plumbagin 1.48 µM 1.13477289973547 0.120322640118676 no 445 0.128235241898428 600 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1547 harmine 94.2 µM 1.13028491471143 0.121293617449863 no 446 0.129178094489639 754 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2038 4100038 30.985 µM 1.12530917927774 0.122376545609903 no 447 0.130229020660912 698 3596803
SGTC_3174 9107204 49.47 µM 1.12369740199266 0.122728786443888 no 448 0.130570709475164 661 3938802
SGTC_989 1501-0895 10.3 µM 1.11906428451577 0.123745274593995 no 449 0.131556357621082 695 2830112
SGTC_1326 1431-2094 10.8 µM 1.11769859151624 0.124046023995138 no 450 0.131847872263727 699 616278
SGTC_181 1447-1644 8.07 µM 1.11626353582607 0.124362598957121 no 451 0.132154672572421 693 534600
SGTC_1113 artemisinin 1.17947 µM 1.11607149820537 0.124405005505446 no 452 0.132195765572728 735 2240 An anti-malaria and mitochondrial poison.
SGTC_237 nikkomycin 200 µM 1.11092945838122 0.125544253950463 no 453 0.133299357145472 714 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_514 4466-0038 2.65 nM 1.10837756586041 0.126112335347564 no 454 0.133849394723175 759 5722064
SGTC_591 4299-0174 154 µM 1.10704758226766 0.126409114672958 no 455 0.134136678298426 685 5509088
SGTC_1445 4239-0156 97.7 µM 1.10549332056248 0.126756556750933 no 456 0.134472943539898 792 4008346
SGTC_369 0957-0393 4.5 µM 1.1047462301382 0.126923798916081 no 457 0.134634782673712 632 6997992
SGTC_1976 st070609 63.5 µM 1.10440905670702 0.126999328166095 no 458 0.134707866933063 726 682556
SGTC_1548 st061468 90.8 µM 1.10304805367839 0.127304520490107 no 459 0.1350031487907 727 390799
SGTC_2684 capsaicin 100 µM 1.09869623173095 0.128283798318899 no 460 0.135950293388212 672 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2223 6903751 107.57 µM 1.09749206066494 0.128555690925012 no 461 0.136213174740774 657 5598863
SGTC_1228 0124-0032 52.5 µM 1.0971324666366 0.128636961995908 no 462 0.136291744749793 715 X1228
SGTC_3256 9138902 49.47 µM 1.0961280393935 0.128864159281203 no 463 0.136511372763853 734 17228773
SGTC_273 hydroxyurea 18.1 mM 1.09584147570781 0.128929029802743 no 464 0.136574077123254 785 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1824 st053723 68.6 µM 1.09443723277969 0.129247241067167 no 465 0.136881630906222 699 675225
SGTC_3169 9102970 49.47 µM 1.09254048118023 0.129677921890527 no 466 0.137297803712389 708 17027839
SGTC_2252 omeprazole 400 µM 1.09236150668203 0.129718611515487 no 467 0.137337117693437 619 4594 A proton pump inhibitor.
SGTC_2326 6164455 177.58 µM 1.0920251058373 0.129795115747405 no 468 0.137411033137921 649 2888790
SGTC_1411 3909-8223 150 µM 1.09082407106112 0.130068509776562 no 469 0.137675151261224 749 X1411
SGTC_519 k048-0011 62.8 µM 1.09077195220585 0.130080382715648 no 470 0.137686620494747 697 6836379
SGTC_654 1124-0271 80.9 µM 1.09072842488394 0.130090299034727 no 471 0.137696199581995 728 5403748
SGTC_3097 9117246 49.47 µM 1.09004877309938 0.130245203990885 no 472 0.137845830005047 708 16423892
SGTC_1760 st045453 10.4495 µM 1.08878223276168 0.130534211878114 no 473 0.13812496422157 749 3323419 YIL048W NEO1
SGTC_394 menadione 8.33 µM 1.08763599806452 0.130796149614386 no 474 0.138377916186958 742 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_312 4092-0653 6.84 µM 1.08632171838136 0.131096935847538 no 475 0.138668340785713 816 1148278
SGTC_1175 0741-0056 27.6 µM 1.08443917571164 0.131528606682656 no 476 0.139085060880794 793 765927
SGTC_2588 indole-3-carbinol 100 µM 1.0821408343912 0.132056949793132 no 477 0.139594976808345 766 3712 Induces cell cycle arrest.
SGTC_3244 9134489 49.47 µM 1.08189515582294 0.132113512887168 no 478 0.139649558802165 705 16584271
SGTC_2964 9083345 53.42 µM 1.08149487238185 0.13220570676407 no 479 0.139738520179682 657 17741579
SGTC_2587 piperic acid 92.2 µM 1.08115577404086 0.132283843092527 no 480 0.139813913553971 655 5370536
SGTC_101 0490-5701 117.494 µM 1.08028280892981 0.132485141466585 no 481 0.140008131307262 675 4661669
SGTC_2132 5317594 122.667 µM 1.07988405463254 0.132577161026306 no 482 0.140096907346839 658 794577
SGTC_99 0109-0120 622.8 µM 1.0797681542774 0.132603915326565 no 483 0.140122717812965 687 759414
SGTC_217 ketoconazole 989 nM 1.07952566177855 0.13265990403806 no 484 0.140176730206033 719 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1833 st055984 71 µM 1.07637014602139 0.133389960892793 no 485 0.140880874238498 723 676288
SGTC_23 0213-0011 39.996 µM 1.07608376353992 0.133456354579379 no 486 0.140944898205867 731 627608
SGTC_3263 9137018 49.47 µM 1.07558648397482 0.133571695736206 no 487 0.141056117428784 685 43844957
SGTC_1632 st005650 90 µM 1.0747834124258 0.133758108304728 no 488 0.141235854298543 705 2759605
SGTC_2755 lomerizine 42.69 µM 1.0708795710697 0.134666832693462 no 489 0.142111791296561 759 3949 A calcium channel blocker.
SGTC_2198 6589944 200 µM 1.07037674119215 0.134784187193848 no 490 0.142224882097171 646 5290268
SGTC_108 0509-0257 621.132 µM 1.06751511437799 0.135453392638383 no 491 0.142869646108179 771 536624
SGTC_956 1185-0240 191 µM 1.06666202918669 0.135653330609739 no 492 0.14306223963244 708 1416193
SGTC_1426 4048-4480 71.7 µM 1.06637572861414 0.135720476294396 no 493 0.143126914483143 749 14224343
SGTC_2534 helenine 20.12 µM 1.06539143529758 0.135951494919468 no 494 0.143349415463061 670 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3296 9122258 64.045 µM 1.0642165584057 0.136227596759343 no 495 0.143615303776642 728 4730474
SGTC_3086 9117350 49.47 µM 1.06196941573504 0.13675675453177 no 496 0.144124784953996 680 2679265
SGTC_934 2950-0684 338 µM 1.06088735863044 0.137012058202281 no 497 0.144370547447825 785 1121253
SGTC_2387 9077560 195.08 µM 1.05909732222743 0.137435119170596 no 498 0.144777729683167 734 5303272
SGTC_1502 4534-4282 27.7 µM 1.0581628714349 0.137656323203463 no 499 0.14499059754352 706 3278949
SGTC_2398 5228213 48.84 µM 1.05815602957362 0.137657943710588 no 500 0.14499215689586 834 80771 YMR134W ERG29
SGTC_564 3555-0129 330 µM 1.0551734157387 0.138365621350805 no 501 0.145673010058571 663 563260
SGTC_1962 st076595 64.5 µM 1.05459134108828 0.138504017476487 no 502 0.145806132824834 743 279619
SGTC_20 0481-0013 4.944 µM 1.05421325845179 0.138593962256334 no 503 0.145892645604894 738 182045
SGTC_1702 st027038 51 µM 1.0521347775238 0.139089137583027 no 504 0.146368859119217 753 5521182
SGTC_1734 st037168 69.4 µM 1.05208415124679 0.13910121374367 no 505 0.146380471421228 742 708907
SGTC_1700 st030840 7.9285 µM 1.05184587122591 0.139158061554435 no 506 0.14643513473561 787 5499307
SGTC_733 4069-0007 56.1 µM 1.05068090073257 0.139436222756693 no 507 0.146702585410785 805 5717425 YNL287W SEC21
SGTC_1782 st039423 80.636 µM 1.04852131477329 0.139952869164532 no 508 0.147199243599605 697 2068169
SGTC_384 k007-0144 5.16 µM 1.04801920400937 0.140073177293896 no 509 0.147314879554928 789 6824886
SGTC_863 0466-0191 129 µM 1.04577738031067 0.140611185996091 no 510 0.14783191345063 805 765160 YPR165W RHO1
SGTC_2710 st078562 53.7235 µM 1.04533626695366 0.140717212420203 no 511 0.147933790717177 749 17250908
SGTC_3180 9109287 49.47 µM 1.04470779861769 0.140868365354175 no 512 0.148079019685704 705 18891271
SGTC_2723 salbutamol 83.58 µM 1.04414414258479 0.141004023942641 no 513 0.14820935270459 664 9884233 β2-adrenoceptor agonist
SGTC_391 gliotoxin 8.33 µM 1.04278565692324 0.14133134312548 no 514 0.148523787852937 807 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1507 4075-3230 155 µM 1.04198202695653 0.14152521533355 no 515 0.148710005913378 684 659771
SGTC_1647 st011722 22.4 µM 1.04192238399573 0.141539611116241 no 516 0.148723832667237 715 2854783
SGTC_982 1491-0518 27.5 µM 1.040023896661 0.14199835986029 no 517 0.149164399277188 708 3091256
SGTC_324 1315-0088 19.6 µM 1.0382659589573 0.14242404292928 no 518 0.149573126104209 680 6787421
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.03755478514243 0.142596498035569 no 519 0.149738688702962 702 4620898
SGTC_1855 st056195 39.6 µM 1.03742461340574 0.142628079132083 no 520 0.149769006159163 737 4028379
SGTC_648 0375-0473 33.3 µM 1.03586089385059 0.143007824357687 no 521 0.150133521984671 796 1713139
SGTC_636 0kpi-0074 126 µM 1.03172372399477 0.144015817626064 no 522 0.151100780183679 732 616434
SGTC_2862 9027634 71.43 µM 1.03168385887049 0.144025553742659 no 523 0.151110120657429 702 5012562
SGTC_3110 9122132 49.47 µM 1.03148720267496 0.144073588877109 no 524 0.151156203196536 798 918317
SGTC_2322 7413319 38.22 µM 1.03127652121827 0.144125061799314 no 525 0.151205582654307 860 1840400
SGTC_734 2023-0417 80 µM 1.031158346882 0.144153939148046 no 526 0.151233285017653 761 3935732
SGTC_3109 9122853 49.47 µM 1.03014951212406 0.144400619094782 no 527 0.151469912937033 826 1234709
SGTC_997 3996-0078 137 µM 1.02717433235487 0.14512976488107 no 528 0.152169191064088 782 735687
SGTC_2145 5634607 200 µM 1.02462777173499 0.145755831114262 no 529 0.152769427686344 711 308662
SGTC_3081 9117243 49.47 µM 1.02269421873905 0.146232401565193 no 530 0.153226222853118 774 45595589
SGTC_1446 4239-0190 62 µM 1.0223046086782 0.146328556831137 no 531 0.153318376322854 817 1340085
SGTC_1421 4029-0249 71.4 µM 1.02170835545325 0.146475793551171 no 532 0.153459477654112 875 2894095
SGTC_940 3232-1287 54.8 µM 1.02103739764697 0.146641596445072 no 533 0.153618360393859 795 1585493 YIL048W NEO1
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.02023895309521 0.146839067120103 no 534 0.153807573864153 822 5393153
SGTC_1241 0364-0022 50.8 µM 1.02004707917436 0.146886547798127 no 535 0.15385306666427 790 4563895
SGTC_1154 4088-0362 150 µM 1.01898939382926 0.147148465004833 no 536 0.154104000904615 840 6618304
SGTC_269 exalamide 29 µM 1.01760094269927 0.147492765568934 no 537 0.154433819586549 761 3316 A derivative of salicylamide.
SGTC_1967 st070177 51.4 µM 1.01512390695561 0.148108346816535 no 538 0.155023383447924 767 5729214
SGTC_2217 6934799 96.0675 µM 1.0145011257725 0.148263387548277 no 539 0.155171846255335 785 675606
SGTC_1780 st038448 24.544 µM 1.01367605559924 0.148468955063093 no 540 0.155368676582449 790 728868 YDL195W SEC31
SGTC_2293 7624732 200 µM 1.0112794015527 0.149067165655063 no 541 0.155941360990507 721 894453
SGTC_1385 3091-4834 14.1 µM 1.01108020640167 0.149116957608738 no 542 0.155989021548125 734 4072814
SGTC_2851 9015922 71.43 µM 1.00968123898578 0.149466964404686 no 543 0.156324016864077 781 2996893
SGTC_2783 7738165 71.43 µM 1.00809439649286 0.149864638780798 no 544 0.156704573731867 674 17201110
SGTC_206 4546-0025 72.014 µM 1.00530399514157 0.150565643864599 no 545 0.15737524597257 848 6620745 YIL048W NEO1
SGTC_2275 7947463 200 µM 1.00366141566936 0.15097931253082 no 546 0.157770920451052 763 1225414
SGTC_1644 st010134 20.9 µM 1.00259947833638 0.151247153970469 no 547 0.158027073807003 765 3818134
SGTC_626 0214-0009 33 µM 1.00203061236892 0.151390763060759 no 548 0.158164404054409 829 3437874
SGTC_351 caspofungin 25 nM 0.999883294300686 0.151933666187859 no 549 0.158683494941923 922 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3147 9097027 49.47 µM 0.999020940520163 0.152152057316266 no 550 0.158892273634544 848 25236841
SGTC_82 0054-0107 293.755 µM 0.99855216022646 0.152270863357181 no 551 0.159005842384716 810 3104697
SGTC_490 phenamil 164 µM 0.997193525750867 0.15261553875023 no 552 0.159335291454344 697 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1286 0929-0070 131 µM 0.995102735193068 0.153146967067074 no 553 0.159843150249796 838 1420408
SGTC_2166 5933061 31.504 µM 0.986971418203179 0.155225398065693 no 554 0.161828325258307 779 2877375
SGTC_544 k015-0020 52.4 µM 0.985475124624797 0.155609881855199 no 555 0.162195372173875 793 3008304
SGTC_56 0957-0365 83.25 µM 0.985322866918812 0.15564904078946 no 556 0.162232751971786 814 6752360
SGTC_2299 7976368 114.88 µM 0.980954669811452 0.156775258784223 no 557 0.16330754798026 811 2979718
SGTC_29 0299-0004 12.984 µM 0.979641477846355 0.157114874588029 no 558 0.163631561542687 719 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2171 5739187 198.077 µM 0.978171855708806 0.157495519436205 no 559 0.163994666862479 764 2262761
SGTC_1735 st034310 56.75 µM 0.973549101196522 0.158696800968517 no 560 0.165140234571456 807 871153
SGTC_927 2425-1185 123 µM 0.972858815487167 0.158876694624564 no 561 0.165311738140458 812 730375
SGTC_1425 4048-4433 7.33 µM 0.972751358748784 0.158904710677361 no 562 0.165338446455212 885 23734946
SGTC_194 1486-1323 56.904 µM 0.972005024557665 0.159099383784376 no 563 0.165524024453384 803 5178754
SGTC_1413 3910-0535 34.4 µM 0.97057622754223 0.15947250552707 no 564 0.165879674361603 883 2876951
SGTC_1975 st070967 30.8 µM 0.97041251269236 0.159515295224024 no 565 0.165920457062737 910 261391
SGTC_3279 9140807 49.47 µM 0.964938640110989 0.160950312113177 no 566 0.167287773084523 845 45595718
SGTC_2528 xanthyletin 44.79 µM 0.963653627589672 0.161288405299745 no 567 0.167609805331554 840 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_429 1112-0049 25.5 µM 0.963637092571866 0.161292758761848 no 568 0.167613951711702 785 2836170
SGTC_558 k064-0027 21.3 µM 0.961989240237183 0.161727001981073 no 569 0.168027504416084 863 5088526
SGTC_3186 9110464 49.47 µM 0.961407216033634 0.161880559327049 no 570 0.168173728718173 816 17018021
SGTC_358 0075-0058 9.45 µM 0.959047437830293 0.162504120308562 no 571 0.168767423944668 911 1069125
SGTC_2551 apiole 73.87 µM 0.957934745202253 0.162798685954803 no 572 0.16904783232007 711 10659 A possible DNA adduct former.
SGTC_2744 captopril 92.04 µM 0.955378269941413 0.163476782028596 no 573 0.169693219454054 797 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2146 5545642 200 µM 0.95421532157297 0.163785856148887 no 574 0.169987330310087 851 825326
SGTC_450 aminopyrene 156 nM 0.95351796329921 0.163971373243644 no 575 0.170163849568016 851 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_751 0833-0568 350 µM 0.95305762921266 0.16409390985108 no 576 0.170280436262595 849 6954252
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.952625370921412 0.164209027007396 no 577 0.17038995890523 776 6857784
SGTC_972 1319-0219 195 µM 0.951949785765443 0.1643890507881 no 578 0.170561224384363 835 23903702
SGTC_521 r062-0005 13.8 µM 0.949084049095998 0.165154108052634 no 579 0.171288933172527 829 2832033
SGTC_128 0906-2981 13.371 µM 0.948177752712558 0.165396538244639 no 580 0.171519485431519 792 6740226
SGTC_662 k832-1615 104 µM 0.947302748194802 0.165630816340196 no 581 0.171742265428057 832 5878478
SGTC_776 4476-4378 112 µM 0.946873798440874 0.165745743845422 no 582 0.17185154540181 814 2892008
SGTC_3162 9099653 49.47 µM 0.946349153491085 0.16588638081728 no 583 0.17198526520237 830 25237511
SGTC_415 dibenzyl ketone 100 µM 0.944198619342467 0.166463661424599 no 584 0.172534080317179 869 7593
SGTC_1661 st013063 9.66 µM 0.944013607220169 0.166513385839995 no 585 0.172581347424066 912 721395
SGTC_1035 k081-0041 55.2 µM 0.942395311846912 0.166948732451019 no 586 0.17299514328555 909 731709
SGTC_1622 st003707 19.4 µM 0.940722897027028 0.167399408659512 no 587 0.173423440996835 893 10140899
SGTC_526 4469-0568 170 µM 0.93975576110026 0.167660386321381 no 588 0.173671427795937 841 2901964
SGTC_1881 5652484 16 µM 0.939235142112499 0.167800981656495 no 589 0.173805014946547 828 2255129
SGTC_891 0929-0073 133 µM 0.93909779161478 0.167838086384432 no 590 0.173840269005729 875 5603632
SGTC_1010 4112-3296 15.2 µM 0.937469486033748 0.168278369562948 no 591 0.174258556337276 912 704384
SGTC_91 0417-1751 58.384 µM 0.937033400415458 0.168396410275523 no 592 0.174370688693796 980 6795624
SGTC_2244 6635614 200 µM 0.931484295608241 0.169903103328569 no 593 0.175801552217646 731 836499
SGTC_1930 st074634 34.3 µM 0.931255798670454 0.169965329536261 no 594 0.175860630252404 853 684253 YOR116C RPO31
SGTC_1433 4060-0023 7.6 µM 0.930085834033693 0.170284173019826 no 595 0.176163322370584 893 3840627
SGTC_1339 1486-1321 22.7 µM 0.930059242354097 0.170291424342385 no 596 0.176170205974731 872 3469382
SGTC_948 3448-0295 75.3 µM 0.929022499440948 0.170574289419117 no 597 0.176438713142404 909 678569
SGTC_1237 0330-0133 46.1 µM 0.925351439871173 0.171578318694389 no 598 0.177391564730391 841 X1237 YHR072W ERG7
SGTC_1849 st056239 19.2 µM 0.925322461746163 0.171586259159608 no 599 0.177399099124856 851 5393181
SGTC_2677 mitomycin C 100 µM 0.924604844156783 0.171782972644166 no 600 0.17758574617591 848 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2853 9015042 58.44 µM 0.920589180929756 0.17288640375452 no 601 0.17863247643248 833 6457456
SGTC_1011 4112-3381 17.4 µM 0.920574300276169 0.172890501068523 no 602 0.178636362462393 875 2877139
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.91871857164227 0.173401951704179 no 603 0.179121396637963 850 279621
SGTC_1774 st048371 48.465 µM 0.9176773069418 0.173689352276351 no 604 0.179393915830602 899 4242727
SGTC_3100 9120536 49.47 µM 0.917182923720985 0.173825913550601 no 605 0.179523396736312 789 16421196
SGTC_1111 tnp00062 510.699 nM 0.916867379737077 0.173913110551778 no 606 0.179606069646748 935 676306
SGTC_2819 7996655 46.38 µM 0.916813457930074 0.173928014013811 no 607 0.179620199619505 784 6456960
SGTC_357 1325-0123 420 µM 0.916689165138697 0.173962370423599 no 608 0.179652772660607 885 1098503
SGTC_155 k072-0202 43.6 µM 0.914969047335865 0.174438280052137 no 609 0.180103939872326 884 5857737
SGTC_1653 st012112 65 µM 0.911932091823015 0.175280539624415 no 610 0.18090223331154 856 720429
SGTC_999 SEC7.066 22.7 µM 0.911874401029239 0.17529656432414 no 611 0.180917419332164 967 740511 YDR170C SEC7
SGTC_1791 st048313 56.1 µM 0.91105315699289 0.175524780982904 no 612 0.181133683067524 863 1204976
SGTC_714 4296-0578 26.1 µM 0.910172999304461 0.175769578194365 no 613 0.18136564063475 890 1589775
SGTC_1699 st031318 29.054 µM 0.908497627610319 0.176236144646884 no 614 0.181807683305242 946 5340658
SGTC_2959 9079155 11 µM 0.90679884850966 0.176710029216611 no 615 0.182256589470363 844 16189457
SGTC_1861 st057647 17.4 µM 0.906548656411942 0.176779889796072 no 616 0.182322761762881 915 688668
SGTC_1500 4488-1866 171 µM 0.905547268359014 0.177059679893995 no 617 0.182587765088045 978 2900003
SGTC_2623 humulene 100 µM 0.904136145778893 0.177454425358017 no 618 0.18296160700161 771 6187145 An anti-inflammatory.
SGTC_149 3970-0822 46.1 µM 0.904015758209697 0.177488128109372 no 619 0.182993522798414 1016 3114250 YBL034C STU1
SGTC_990 3985-0011 41.3 µM 0.90172974686362 0.178128868401905 no 620 0.183600223523784 847 5399565 YGL099W LSG1
SGTC_289 k017-0060 526 µM 0.901390686651944 0.178224026745865 no 621 0.183690315739141 903 5512909
SGTC_651 3253-0966 34.4 µM 0.899578101324023 0.178733277971166 no 622 0.184172407674003 928 781462
SGTC_285 1486-1325 46 µM 0.899152088076102 0.178853100488455 no 623 0.184285828284224 931 22310230
SGTC_1977 st070720 65.3 µM 0.898522258379074 0.179030342000228 no 624 0.184453592043047 860 682188
SGTC_779 1360-0071 233 µM 0.898302093794904 0.179092324972185 no 625 0.184512258294208 972 7566
SGTC_2428 5615643 7.78 µM 0.8962021889986 0.179684189809427 no 626 0.185072393400546 888 2253075
SGTC_1974 st069448 26.9 µM 0.894606244914749 0.180134832716769 no 627 0.18549880617536 911 6323587 YNR016C ACC1
SGTC_3142 9086498 49.47 µM 0.893796803952999 0.180363663551548 no 628 0.185715309762674 859 25236367
SGTC_796 1234-0020 70.7 µM 0.893719870240894 0.180385422377662 no 629 0.185735895606641 885 46495034
SGTC_465 cgp-37157 41 µM 0.893660616409889 0.180402182002799 no 630 0.185751751651037 808 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2419 paclitaxel 166.5 µM 0.892003206358695 0.180871367239894 no 631 0.186195606896443 949 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1876 myriocin 605 nM 0.89054960451891 0.181283486682647 no 632 0.186585422733921 943 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1407 3909-7909 12.3 µM 0.890229409374769 0.181374346114512 no 633 0.186671358092074 960 4411780
SGTC_1998 st075797 76.8 µM 0.889756910860192 0.18150847562921 no 634 0.186798214037605 996 24208315
SGTC_1606 st000094 49.2 µM 0.887279516723196 0.182212756397413 no 635 0.187464215349504 987 1242210
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.886175819591232 0.182527067810743 no 636 0.187761395739878 946 688669
SGTC_1650 st011916 45.8 µM 0.886155057254544 0.182532983762442 no 637 0.187766988972932 935 242528
SGTC_1954 st077032 68.9 µM 0.885951089387875 0.182591108060333 no 638 0.187821942007702 828 698907
SGTC_1423 4048-0112 5.59 µM 0.880499462348022 0.184148927822072 no 639 0.189294398153625 961 X1423
SGTC_1988 st071872 53.4 µM 0.88012657345322 0.184255783437493 no 640 0.189395372497835 959 16414116
SGTC_524 r073-0010 27.8 µM 0.877751630728025 0.184937255824969 no 641 0.190039259366705 896 2772106
SGTC_1171 0368-0077 21.4 µM 0.87696056793042 0.185164592769237 no 642 0.190254028134995 883 3239779
SGTC_1194 1488-0194 225 µM 0.873780134289358 0.186080341655547 no 643 0.191119000513517 951 1391452
SGTC_496 calpeptin 138 µM 0.872550696835495 0.186435087229072 no 644 0.191454011899592 868 73364 A calpain inhibitor.
SGTC_2116 5511452 16.8835 µM 0.871643368421704 0.186697158959234 no 645 0.191701481887572 938 870744
SGTC_1300 1094-0077 113 µM 0.871598773949203 0.186710045454306 no 646 0.191713649889791 882 5532636
SGTC_2081 5214970 32.255 µM 0.868866995660113 0.18750049901627 no 647 0.192459941795733 967 2063512
SGTC_819 1013-0258 27.7 µM 0.868006597106352 0.187749887233346 no 648 0.192695360568744 947 5753198
SGTC_525 k781-2675 26.7 µM 0.867417507123197 0.187920754229171 no 649 0.192856646426603 964 3651118 YDL195W SEC31
SGTC_297 0986-0032 24 µM 0.866940970168536 0.188059045167935 no 650 0.192987176914466 926 2847425
SGTC_2379 9035213 200 µM 0.865933409491355 0.188351645845822 no 651 0.193263340190818 995 646551
SGTC_1114 scopoletin 1.73284 µM 0.865437801210591 0.188495675965176 no 652 0.193399270393545 950 5280460 A coumarin with genotoxic properties.
SGTC_1884 5633444 25 µM 0.865209771237358 0.188561967206176 no 653 0.19346183163377 948 5724239
SGTC_1609 st001574 46.4 µM 0.862547060594384 0.189337114958803 no 654 0.194193273945757 987 3960012
SGTC_1395 3486-0190 4.35 µM 0.860664810895256 0.189886242512238 no 655 0.194711339622546 999 6748079
SGTC_707 0865-0008 204 µM 0.859626683824164 0.190189524237176 no 656 0.194997430518161 1015 723043
SGTC_1939 st074455 53.6 µM 0.858549174528061 0.190504625785399 no 657 0.19529464465204 967 1644229
SGTC_1066 ketoconazole 628 nM 0.858387639149204 0.19055189201515 no 658 0.195339225379529 1008 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1322 1348-1070 12 µM 0.85629408394566 0.191165130089276 no 659 0.195917566400343 966 6758089
SGTC_295 k015-0027 31 µM 0.856131446284131 0.191212820035257 no 660 0.195962538221987 948 3887424
SGTC_1673 st016611 27.3 µM 0.855616233679331 0.191363943034265 no 661 0.196105043792346 984 5226799
SGTC_851 0394-0702 453 µM 0.85490700034452 0.191572096206239 no 662 0.196301317434875 1018 762646
SGTC_2297 7971671 152.32 µM 0.8514275530863 0.192595288448348 no 663 0.19726594574358 954 909016
SGTC_116 0155-0182 31.788 µM 0.850631106660658 0.192829966373495 no 664 0.19748715206879 1013 771486
SGTC_2109 5483026 200 µM 0.850488736496623 0.192871935030335 no 665 0.197526709985002 981 759335
SGTC_832 4083-0019 164 µM 0.849469835739469 0.193172455001457 no 666 0.197809953979474 1123 1990758
SGTC_3309 9129340 25.759 µM 0.849282956397721 0.193227605186019 no 667 0.197861931145777 1013 17158987
SGTC_703 3875-0075 71.8 µM 0.8476214896054 0.193718345040692 no 668 0.198324401265216 1025 2850814
SGTC_272 doxorubicin 8.13 µM 0.84725115591862 0.193827832285395 no 669 0.198427572673174 1034 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1007 4101-0031 70 µM 0.843839417206652 0.194838268697791 no 670 0.199379572867836 1000 1146276
SGTC_2655 perillic acid 100 µM 0.841427520218355 0.195554516540627 no 671 0.200054236783492 954 5702197 An apoptosis inducer.
SGTC_676 falcarinol 140 µM 0.840569274674929 0.195809770222053 no 672 0.200294638789059 1029 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2144 5628481 200 µM 0.840231017615218 0.195910427913113 no 673 0.200389435185915 965 2818399
SGTC_186 3455-3465 67.277 µM 0.838471438153301 0.19643454543477 no 674 0.200882991174354 940 755278
SGTC_2949 9072542 2.23 µM 0.837448166765435 0.196739732800696 no 675 0.201170350418733 1008 16457352
SGTC_1733 st037357 54.9 µM 0.83643414339373 0.197042445085405 no 676 0.201455355622329 978 1272339 YGL099W LSG1
SGTC_2480 5767542 37.17 µM 0.835853869444648 0.197215798657296 no 677 0.20161855838669 1007 2867358
SGTC_2780 5215298 71.43 µM 0.83417438187267 0.197718055857261 no 678 0.202091362490275 1024 2834131
SGTC_2075 5212009 200 µM 0.833208062386713 0.198007387410109 no 679 0.20236369817444 909 780898
SGTC_2406 ethylparaben 405.7 µM 0.832314350787704 0.198275206470832 no 680 0.20261576619399 846 8434 A possible steroid mimic.
SGTC_1505 k297-0037 20.6 µM 0.831868646044311 0.19840885273269 no 681 0.202741545653983 976 4089396
SGTC_48 0382-0018 55 µM 0.831124463881941 0.198632119691241 no 682 0.202951660453555 1002 762596
SGTC_249 wiskostatin 11.211 µM 0.829859714773278 0.199011912743791 no 683 0.203309051996352 1020 2775510 A n-wasp and actin depolymerizer.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.828628842415621 0.199381952742801 no 684 0.203657231040147 1068 1273210
SGTC_83 0170-0301 39.027 µM 0.827561910382205 0.199703041910972 no 685 0.20395932346895 948 3089716
SGTC_452 diindolylmethane 8 µM 0.826064039680777 0.200154345042345 no 686 0.204383882661047 921 3071 Inhibits expression of several cancer promoting factors.
SGTC_2224 6650123 117.647 µM 0.823938489798446 0.200795816763003 no 687 0.204987254514648 983 2908370
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.8233237903589 0.200981557247293 no 688 0.205161944128919 1000 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1034 k072-0165 12.7 µM 0.823231584932 0.201009427361743 no 689 0.205188155344116 1029 5835461
SGTC_1223 0764-0573 147 µM 0.822562799174828 0.201211644667601 no 690 0.205378330464116 1049 1609797
SGTC_2704 st078022 71.1 µM 0.822486515131959 0.201234718028437 no 691 0.205400029153044 1020 54697681
SGTC_1341 1486-1360 280 µM 0.821559402884846 0.201515265123379 no 692 0.205663851309741 1006 3976547
SGTC_1334 1486-0610 236 µM 0.821531204895683 0.201523801594668 no 693 0.205671878574103 1003 3742339
SGTC_503 tyrphostin 8 294 µM 0.818045944201498 0.202580573835238 no 694 0.206665476647708 1007 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3211 9128781 49.47 µM 0.813690168219652 0.203905943073113 no 695 0.20791123397022 924 17194361
SGTC_376 3970-0862 59.1 µM 0.81368304165734 0.203908115758784 no 696 0.207913275802325 1041 3135186
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.812590158079434 0.204241468063026 no 697 0.208226538099991 1051 115019
SGTC_572 0960-0087 17.7 µM 0.812585618493101 0.204242853408062 no 698 0.208227839899859 1085 6796365
SGTC_458 nppb 133 µM 0.812280895660956 0.204335858432997 no 699 0.208315235084304 1008 4549 A chloride channel blocker.
SGTC_1811 st050069 61.5 µM 0.811860205950701 0.204464299350353 no 700 0.208435925377772 1043 3877702
SGTC_963 1269-2853 151 µM 0.811699727145493 0.204513307846973 no 701 0.208481975480268 997 3668223
SGTC_1871 st057448 67.3 µM 0.810619793374037 0.204843289746559 no 702 0.208792023245609 1047 691747
SGTC_1953 st076800 12.1 µM 0.810340564887265 0.204928661601644 no 703 0.208872233615024 952 297591
SGTC_71 0417-1750 47.813 µM 0.809668743398063 0.20513415225413 no 704 0.209065293486293 1030 6811472
SGTC_1619 st003326 88.7 µM 0.80767240571516 0.205745496010132 no 705 0.209639596400733 1018 2849032
SGTC_688 0527-0193 473 µM 0.806589796574492 0.206077477922742 no 706 0.209951427103169 987 4007154
SGTC_2893 9048488 25.97 µM 0.806585260291646 0.206078869641055 no 707 0.209952734290386 1021 6467338
SGTC_157 1348-1695 65.819 µM 0.805806165129388 0.206317976425938 no 708 0.210177311348659 1019 5380510
SGTC_1905 st060207 84.5 µM 0.805789198035846 0.206323185509614 no 709 0.210182203745374 1007 1948547
SGTC_261 5-fluorouridine 15.376 µM 0.804027990901039 0.206864319245541 no 710 0.210690404839354 1007 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2836 9010338 19.48 µM 0.803941309301635 0.206890973979242 no 711 0.210715435648606 999 2994051
SGTC_504 lovastatin 124 µM 0.803365415850621 0.207068113767238 no 712 0.21088177912092 1016 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_835 0312-0010 67.2 µM 0.803264298159546 0.207099225942649 no 713 0.210910994322724 995 1626196
SGTC_1784 st039334 36.3 µM 0.803176622960694 0.207126204332552 no 714 0.210936327603491 1036 3496984
SGTC_373 0844-0104 25.9 µM 0.801486091004965 0.207646801500148 no 715 0.211425146539191 1094 5375804
SGTC_2177 5811945 192 µM 0.799409344269608 0.208287390070636 no 716 0.212026546981859 1062 5343475
SGTC_1136 pergolide 1.05886 µM 0.798933053666284 0.208434469773358 no 717 0.212164615813371 997 47811 A dopamine receptor agonist.
SGTC_2159 5658611 73.75 µM 0.797678700022562 0.20882211019288 no 718 0.21252848375369 1078 793844
SGTC_2484 5809818 12.04 µM 0.797473650283539 0.208885518312914 no 719 0.212588000050301 997 2870548
SGTC_1919 st067113 52.3 µM 0.796663050446618 0.209136293458721 no 720 0.212823374345417 1006 1268243
SGTC_2610 ononetin 44.17 µM 0.796287504156532 0.209252536217577 no 721 0.212932473459266 1026 259632
SGTC_361 000s-0510 1.45 µM 0.796252998554365 0.209263218636264 no 722 0.212942499241543 1024 660
SGTC_1640 st009078 66.4 µM 0.795447740087057 0.209512605764966 no 723 0.213176549496015 989 690618
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.794819616628606 0.209707255815693 no 724 0.213359219161413 1090 551469
SGTC_2106 5357045 167.29 µM 0.794516609847955 0.209801193016114 no 725 0.213447371632741 1039 668842
SGTC_2921 7974240 10.71 µM 0.79367146639936 0.210063332390941 no 726 0.213693357764581 1019 2979074 YDR527W RBA50
SGTC_3056 9094900 49.47 µM 0.793197230096756 0.210210511202545 no 727 0.213831460539948 1029 25236784
SGTC_2492 derrusnin 100 µM 0.793110313392089 0.210237492289608 no 728 0.213856777265245 978 1715307 Part of coumarin class of compounds.
SGTC_2161 5662504 8.5105 µM 0.791354311085284 0.210783034158166 no 729 0.214368631808023 996 2859334
SGTC_1056 3448-1962 115 µM 0.788863622311845 0.211558245365858 no 730 0.215095859663394 1009 715507
SGTC_2314 7727897 200 µM 0.784552774029121 0.212903907206512 no 731 0.216357914202089 1071 900724
SGTC_1491 4138-0063 26.5 µM 0.784085810019898 0.213049972588398 no 732 0.216494880551926 1050 23883227
SGTC_649 1123-0311 367 µM 0.781824584870818 0.213758105674116 no 733 0.217158835309181 1072 693629 YIL048W NEO1
SGTC_768 0384-0033 77.3 µM 0.781795821818997 0.213767122031474 no 734 0.217167288462202 1034 3965305 YMR134W ERG29
SGTC_284 0988-0104 32.6 µM 0.781038950434968 0.214004458185123 no 735 0.217389793163014 1094 4666532
SGTC_3004 9076122 71.4286 µM 0.778439082332353 0.214820879972419 no 736 0.218155103088024 1063 44782551
SGTC_2490 carminic acid 95.39 µM 0.778291987785808 0.214867125255661 no 737 0.218198448920726 1028 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_945 3381-0768 11.3 µM 0.776134982254725 0.215545933462494 no 738 0.218834645243951 1107 1126236 YIL048W NEO1
SGTC_3340 9146634 11.102 µM 0.774691671715726 0.216000836009414 no 739 0.219260936689877 1079 4907387
SGTC_1251 0490-5699 265 µM 0.773995859328756 0.216220340671035 no 740 0.219466619945242 1140 3883818
SGTC_2196 6573537 42.6665 µM 0.773620702288606 0.216338743269816 no 741 0.21957756294445 1088 2903087
SGTC_2827 7993847 71.43 µM 0.773063445121677 0.216514687402991 no 742 0.219742416792757 1002 2985692
SGTC_2381 9035592 200 µM 0.771864985380925 0.21689336032459 no 743 0.220097198759529 1004 4749657
SGTC_2846 9008642 19.48 µM 0.770992093168369 0.217169405677242 no 744 0.220355809122448 1039 2992898
SGTC_766 1391-0721 126 µM 0.770955451441673 0.217180997774433 no 745 0.22036666871562 1088 1020919 YIL115C NUP159
SGTC_1380 2291-0730 164 µM 0.770497251618378 0.217325985556924 no 746 0.220502492357472 1059 2999191
SGTC_425 3825-7017 13.1 µM 0.770460131476857 0.217337733898939 no 747 0.220513497938168 1081 3397440
SGTC_182 3448-4371 550.524 µM 0.761950992488556 0.220040497191241 no 748 0.22304462707021 1125 3491403
SGTC_2242 6630449 61.2675 µM 0.760482658939516 0.220508827967607 no 749 0.223483065459122 1009 691249 YDR170C SEC7
SGTC_410 α-linolenic acid 100 µM 0.760470851001695 0.220512596469642 no 750 0.223486593247036 1107 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2134 5324836 1.464 µM 0.759910767767653 0.220691389357673 no 751 0.22365396239384 1033 699272
SGTC_2524 avocatin b 10.57 µM 0.759903873833127 0.220693590595018 no 752 0.22365602294576 1053 6710748
SGTC_1079 idarubicin 2.36 µM 0.759035822652675 0.220970860313695 no 753 0.2239155640025 1068 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_720 r052-1644 49.9 µM 0.758611676824884 0.221106411897989 no 754 0.224042442770973 1040 1422863 YOR257W CDC31
SGTC_2497 7-hydroxyflavone 100 µM 0.757989868040003 0.221305220016856 no 755 0.224228524141664 1025 5281894
SGTC_531 3788-1495 174 µM 0.757310677328363 0.221522491376822 no 756 0.22443187776496 1030 2896655
SGTC_2690 usnic acid 100 µM 0.757290775620555 0.221528859720145 no 757 0.224437838029221 1143 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_933 2914-0560 114 µM 0.757120660415314 0.221583299119229 no 758 0.224488788658066 1155 463887
SGTC_2201 6605497 169.863 µM 0.756607761654576 0.22174748063158 no 759 0.224642444947823 1105 670741
SGTC_453 enantio-paf c16 10 µM 0.756285664858869 0.221850620977184 no 760 0.224738970499556 1113 13871343 A lipid and platelet activating factor
SGTC_3203 9113543 49.47 µM 0.754992772187432 0.222264900708106 no 761 0.225126659506822 1078 17018012
SGTC_2175 5807670 165.306 µM 0.754965134699761 0.22227376136439 no 762 0.225134951065386 1085 241186
SGTC_122 0236-0016 402.397 µM 0.754209730109556 0.222516024225405 no 763 0.225361647957181 1198 6808838
SGTC_311 1315-0136 58 µM 0.75384701648382 0.222632402181902 no 764 0.225470544216935 1093 6759207
SGTC_1389 3405-0187 19 µM 0.750762999784031 0.223623320573659 no 765 0.226397650333208 1070 799890
SGTC_1243 0416-0003 5.65 µM 0.748334324556519 0.224405434818931 no 766 0.227129262812887 1100 2141977
SGTC_3091 9116372 49.47 µM 0.748245720564174 0.224433997575718 no 767 0.227155978993696 1094 17169793
SGTC_528 3492-0019 172 µM 0.748232091035858 0.224438391431061 no 768 0.227160088773188 1171 2869262
SGTC_1993 st073995 70.8 µM 0.748101330203668 0.224480548281985 no 769 0.227199519867434 1115 3098394
SGTC_959 1222-0044 107 µM 0.74750317391647 0.224673449130145 no 770 0.227379943829418 1109 6083612
SGTC_1062 mesoridazine 14.2 µM 0.746938242863172 0.224855721392327 no 771 0.227550420040328 1132 4078 A neuroleptic.
SGTC_1523 st012844 44.7 µM 0.746891194509838 0.22487090509586 no 772 0.227564620815255 1105 4274103
SGTC_826 1683-5028 118 µM 0.745944207192246 0.225176645621157 no 773 0.227850559517227 1102 722377
SGTC_736 0958-0254 92.6 µM 0.745541678441753 0.225306675724318 no 774 0.227972162526863 1146 6812352
SGTC_745 0469-0705 296 µM 0.743601845468111 0.225933901824544 no 775 0.228558693217319 1204 3486736
SGTC_3225 9130819 49.47 µM 0.741838281894788 0.226504988706858 no 776 0.229092661617083 1109 4547121
SGTC_1455 4262-0120 131 µM 0.741370468663114 0.226656615226487 no 777 0.229234422551251 1137 1529587
SGTC_2871 9038510 12.99 µM 0.740221616902581 0.227029221325088 no 778 0.229582766484948 1159 4945164
SGTC_164 4100-3994 89.624 µM 0.739872946464316 0.227142373587242 no 779 0.229688545658006 1164 4615967
SGTC_2330 7979373 200 µM 0.738312860762276 0.227649049504372 no 780 0.23016217654392 1121 1863007
SGTC_294 k038-0071 157 µM 0.737747343293657 0.227832872117853 no 781 0.230333998436257 1129 24152826
SGTC_2126 5251174 33.877 µM 0.735565262296697 0.228542944414725 no 782 0.230997654744932 1181 790722
SGTC_2767 sibutramine 71.45 µM 0.7349353122793 0.228748167830691 no 783 0.231189445593038 1153 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_315 k915-0449 187 µM 0.732214728811543 0.229635659417793 no 784 0.232018757903263 1172 20970215 YNL149C PGA2
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.731588263575785 0.22984029382315 no 785 0.232209956917 1208 5024745
SGTC_1071 trifluoperazine 6.31 µM 0.731572679344909 0.229845385701765 no 786 0.2322147143871 1154 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3029 9088683 49.47 µM 0.731163835327261 0.229978990991705 no 787 0.232339543462904 1178 25236615
SGTC_491 tetrandrine 80.3 µM 0.731082504120747 0.230005574230658 no 788 0.232364380120952 1112 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_543 3844-1095 191 µM 0.731041490739168 0.230018980174253 no 789 0.232376905213526 1151 4230703
SGTC_2749 bexarotene 57.39 µM 0.730149557477301 0.230310632349252 no 790 0.232649385931716 1141 82146 An retinoic acid receptor inhibitor.
SGTC_2912 7964298 10.93 µM 0.727713820232561 0.231108143609382 no 791 0.233394394267314 1187 2975850
SGTC_1898 st060199 18.6 µM 0.726550432116165 0.231489604353385 no 792 0.233750701257998 1182 688866
SGTC_3233 9132340 49.47 µM 0.72626680815822 0.231582654375187 no 793 0.23383761150935 1125 17682950
SGTC_2300 7976697 71.57 µM 0.72613203814978 0.231626876394987 no 794 0.233878915055098 1053 2236109
SGTC_506 n9-isopropylolomoucine 153 µM 0.725660648530363 0.231781590263746 no 795 0.234023415658204 1152 6610355
SGTC_550 4123-0385 25.7 µM 0.723422495850679 0.232516955048119 no 796 0.234710177268348 1158 5731123
SGTC_1235 benzylparaben 21.5 µM 0.722721457864825 0.232747553785059 no 797 0.234925514859663 1130 7180
SGTC_899 1083-0020 478 µM 0.722279858216901 0.23289287835293 no 798 0.235061216894272 1161 767123
SGTC_1106 tegaserod maleate 11.7 µM 0.721190784632074 0.233251493333448 no 799 0.235396070419365 1160 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_687 k029-0044 34.9 µM 0.721120172482135 0.233274755390271 no 800 0.235417790366904 1179 5829338
SGTC_3288 9119690 36.221 µM 0.720680049236548 0.233419776055593 no 801 0.235553195025938 1134 17595618 YKL019W RAM2
SGTC_1659 st012954 42.1 µM 0.72065678728093 0.233427442264255 no 802 0.235560352801108 1119 24207262
SGTC_2208 7283366 200 µM 0.720510746129862 0.233475574767962 no 803 0.235605292853051 1167 898663
SGTC_337 1315-0038 354 µM 0.720098917957938 0.233611335479556 no 804 0.235732046845651 1133 1626437
SGTC_314 1671-0008 2.74 µM 0.720086596509968 0.233615397965683 no 805 0.235735839765604 1105 3913060
SGTC_3035 9091303 49.47 µM 0.71985331365222 0.233692320697984 no 806 0.235807657740871 1180 25237002
SGTC_3193 9111931 49.47 µM 0.719080503642201 0.233947247490426 no 807 0.236045659573606 1193 17087244
SGTC_189 3970-0742 2.116 µM 0.716345084779703 0.234850816540777 no 808 0.236889147290878 1182 2891807
SGTC_1234 0326-0494 15.5 µM 0.715213221124074 0.23522525944592 no 809 0.237238650361997 1163 1547813
SGTC_612 0302-0167 22.4 µM 0.714286944968449 0.23553193504645 no 810 0.237524881604145 1202 235821
SGTC_360 0957-0399 1.01 µM 0.713413254932566 0.235821402254783 no 811 0.237795036675189 1169 6752301 YPR165W RHO1
SGTC_1078 idebenone 36.1 µM 0.711777122576982 0.236364005723129 no 812 0.238301400724791 1185 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2352 9027995 87.8 µM 0.709700736742941 0.23705360243086 no 813 0.238944867597853 1127 2997347
SGTC_1837 st055472 66.5 µM 0.708731599132177 0.237375844610669 no 814 0.239245525859349 1229 676091
SGTC_2097 5376186 200 µM 0.707949244850445 0.237636155930762 no 815 0.239488388510277 1134 742755
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.7079002004979 0.23765247958482 no 816 0.23950361760619 1113 1241132 A phosphatase inhibitor.
SGTC_3239 9133757 49.47 µM 0.707003237121058 0.237951128460662 no 817 0.239782233056163 1172 17036923
SGTC_169 k015-0017 16.025 µM 0.706881120135317 0.237991803888101 no 818 0.239820178799378 1205 1840002
SGTC_1174 0739-0097 51.1 µM 0.704551096639255 0.238768631224987 no 819 0.240544820532194 1182 728447
SGTC_1842 st055362 61.2 µM 0.704263355681485 0.238864659888056 no 820 0.240634391148047 1179 676032
SGTC_2163 5671233 125 µM 0.704053240314795 0.238934795668672 no 821 0.240699809233526 1221 701023
SGTC_699 0375-0592 111 µM 0.702829657311789 0.239343447071728 no 822 0.241080956268991 1214 762578
SGTC_2569 tetrandrine 100 µM 0.701887972531531 0.239658210088494 no 823 0.241374515106011 1132 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_287 k060-0039 29.6 µM 0.701065073352123 0.239933453270299 no 824 0.241631202886839 1198 5861974
SGTC_818 4072-2707 53.5 µM 0.699500219034212 0.240457340784465 no 825 0.242119738090434 1156 882871
SGTC_1936 st074407 74.3 µM 0.698707225291955 0.240723059709788 no 826 0.242367508804041 1228 809813
SGTC_886 0866-0150 153 µM 0.697131934936785 0.24125138683638 no 827 0.242860115180631 1219 271463
SGTC_382 3229-0966 23.2 µM 0.695807768105163 0.241695978193268 no 828 0.243274611890292 1208 5722370
SGTC_113 0099-0221 2.5 µM 0.694929699883572 0.241991036208612 no 829 0.243549679495299 1209 89219
SGTC_2696 st077691 74.316 µM 0.694831283744534 0.242024119239491 no 830 0.243580520243923 1176 757133
SGTC_2119 5528445 120.635 µM 0.694110415501523 0.242266517131485 no 831 0.243806483624585 1189 791935
SGTC_2248 tofa 1.1 µM 0.691251758287562 0.243229058356825 no 832 0.244703671271041 1144 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2951 9072950 58.06 µM 0.691203745913188 0.243245242282971 no 833 0.244718755086442 1231 16488155
SGTC_1018 4259-0013 28.1 µM 0.691040463308885 0.243300285649854 no 834 0.244770056538282 1190 6801262
SGTC_3155 9099265 49.47 µM 0.690309450346056 0.24354679621973 no 835 0.244999803077934 1154 25236499
SGTC_1570 verbenone 133 µM 0.689831338059683 0.243708097124259 no 836 0.245150129413433 1220 29025 A natural terpanoid with antifungal properties.
SGTC_1800 st050079 29.0735 µM 0.686935376661348 0.244686340102003 no 837 0.246061726301545 1193 3645560
SGTC_67 0335-0847 266 µM 0.686049453431163 0.244986022844499 no 838 0.246340961890607 1265 4552207 YOR254C SEC63
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.685620396065529 0.245131231747721 no 839 0.246476258208464 1284 6728940
SGTC_2115 tiliquinol 12.7705 µM 0.68486647913519 0.245386497243958 no 840 0.24671409016512 1188 71208 A bioactive hydroxyquinoline.
SGTC_3220 9131269 49.47 µM 0.684364767151921 0.245556448884194 no 841 0.24687242918061 1249 17722206
SGTC_34 0469-0683 81.75 µM 0.684182332673065 0.245618263038404 no 842 0.246930018516461 1208 3690923
SGTC_673 1082-0474 110 µM 0.683413071084885 0.245879003326912 no 843 0.247172931402031 1248 3098046
SGTC_248 streptozotocin 5.23457 mM 0.679454187371237 0.247223208468775 no 844 0.248425062923821 1249 5300 DNA alkylating agent.
SGTC_2280 7785178 200 µM 0.678041897748124 0.247703688566397 no 845 0.248872564241334 1221 2954328
SGTC_2456 5770359 74.46 µM 0.67771941442139 0.247813471663827 no 846 0.248974807187599 1232 3118787
SGTC_1412 3909-8563 178 µM 0.67697631318015 0.248066544705276 no 847 0.249210491602598 1281 23767530
SGTC_80 0159-0065 512.242 µM 0.675937639626872 0.24842050975646 no 848 0.249540119412933 1167 1548079
SGTC_2913 7966556 36.57 µM 0.675588885475408 0.248539420507457 no 849 0.249650850066433 1169 2976516
SGTC_3260 9137109 49.47 µM 0.673251699670466 0.249337086232711 no 850 0.250393587662602 1116 17478346
SGTC_234 nsc-17383 10.7 µM 0.672924645064857 0.249448816207043 no 851 0.250497616148766 1259 408974
SGTC_2294 7971431 200 µM 0.672902490647583 0.24945638566823 no 852 0.250504663783303 1178 5741572
SGTC_502 l-744,832 89.3 µM 0.672797114622664 0.249492390982284 no 853 0.250538186830582 1201 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2937 9044753 11.33 µM 0.672349132211516 0.249645490276624 no 854 0.250680729035378 1242 6465530 YGL099W LSG1
SGTC_1039 k821-0043 94 µM 0.672278478247556 0.249669641029605 no 855 0.250703214132843 1217 15992768
SGTC_622 1348-1566 26.3 µM 0.672135549913666 0.249718500212366 no 856 0.250748703275496 1257 7340407
SGTC_316 k060-0003 58.6 µM 0.67135114961885 0.249986733062856 no 857 0.250998428536834 1257 6152314
SGTC_477 mead ethanolamide 10 µM 0.671275454340503 0.250012625841713 no 858 0.251022534192242 1122 16061185
SGTC_3232 9132874 49.47 µM 0.668058149988633 0.251114470544907 no 859 0.252048237229103 1210 3784940
SGTC_1792 st045773 43.6 µM 0.667035349980491 0.25146529081153 no 860 0.252374776873045 1195 2919270
SGTC_1450 4112-4260 37.6 µM 0.666495495092109 0.251650565345873 no 861 0.25254722108478 1229 1633175
SGTC_2874 9043904 71.43 µM 0.666416727153467 0.251677603994062 no 862 0.252572386877401 1201 4463428
SGTC_912 3474-0017 2.18 µM 0.665746050155444 0.251907889236165 no 863 0.252786716879952 1281 3360550
SGTC_1262 0737-0114 49.6 µM 0.665081935439677 0.252136030777642 no 864 0.252999044076518 1272 765919
SGTC_1959 st077091 55.8 µM 0.664863835418727 0.252210977856495 no 865 0.253068794309837 1251 821356 YKL052C ASK1
SGTC_1158 4092-0494 91.8 µM 0.66469024913961 0.252270636794153 no 866 0.253124315900713 1319 1148199
SGTC_1115 galangin 695.678 nM 0.664465741724053 0.252347807577769 no 867 0.253196134123828 1283 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1914 st062367 72.6 µM 0.664392164460305 0.252373101276308 no 868 0.253219673264858 1239 978205
SGTC_780 0109-0199 192 µM 0.663344762796227 0.252733312021376 no 869 0.253554887066914 1265 610414
SGTC_1767 st044992 70.3 µM 0.661617718801161 0.253327848515533 no 870 0.254108124493674 1214 9600693
SGTC_1348 1493-0373 93.8 µM 0.660332938177285 0.25377061188937 no 871 0.254520098599594 1251 3010129
SGTC_807 1315-0151 48 µM 0.659918790879586 0.253913422609651 no 872 0.254652972436901 1276 4011080
SGTC_1687 st020778 55.3625 µM 0.659884970673046 0.253925086719139 no 873 0.254663824819726 1251 4259299
SGTC_897 1000-0139 31.4 µM 0.659508140920526 0.254055068974575 no 874 0.254784760059182 1246 6151020
SGTC_1516 st013856 110 µM 0.659448301317973 0.254075713035964 no 875 0.254803967032303 1248 5281404 A mutagen and neurotoxin.
SGTC_3139 9095020 49.47 µM 0.658480330490181 0.254409775450566 no 876 0.255114766035146 1079 25236292
SGTC_2135 5326629 150.42 µM 0.658462051739768 0.254416085957179 no 877 0.255120636938513 1227 5020077
SGTC_2726 cimetidine 79.27 µM 0.657630372991718 0.254703299246549 no 878 0.255387836362996 1239 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2070 5230947 200 µM 0.655560109622909 0.255418984027709 no 879 0.256053599408181 1317 2835538
SGTC_2288 7946289 167.31 µM 0.654205101336703 0.255887975306182 no 880 0.256489837710156 1300 1246052
SGTC_1357 1503-1303 39.5 µM 0.653448208308279 0.256150144273999 no 881 0.256733684163937 1266 292895
SGTC_632 0781-2353 4.65 µM 0.653046848336548 0.256289222220584 no 882 0.256863038315807 1298 6811515 YHR007C ERG11
SGTC_1229 0139-0193 12.2 µM 0.652856510680132 0.256355191160676 no 883 0.256924394020446 1300 3090752
SGTC_403 arphamenine a 50 µM 0.652371389314689 0.256523368908101 no 884 0.257080808292104 1222 5487158 An arginine aminopeptidase inhibitor.
SGTC_1159 4092-0538 61.2 µM 0.650444921477036 0.257191787231307 no 885 0.257702434247857 1297 717301
SGTC_1060 3448-7350 82 µM 0.649773637234802 0.257424912419335 no 886 0.25791922510039 1243 570178
SGTC_2413 inermin 26.06 µM 0.649131350727108 0.257648069939033 no 887 0.258126739693138 1375 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.648383446362614 0.257908050095243 no 888 0.258368487119174 1200 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_689 0833-0039 98 µM 0.646823729198841 0.258450663285884 no 889 0.258873016453285 1262 5374726
SGTC_3163 9099914 49.47 µM 0.646806977275965 0.25845649435479 no 890 0.258878438045107 1304 16268368
SGTC_2402 5553605 200 µM 0.641838440608745 0.26018896302147 no 891 0.260489043797879 1317 6758546
SGTC_2928 9011484 9.79 µM 0.641493349886582 0.260309513892472 no 892 0.260601100078269 1272 2994751
SGTC_1843 st055809 45.5 µM 0.64124293029943 0.260397011219942 no 893 0.260682430714852 1280 16413835
SGTC_570 0987-0065 62.6 µM 0.63790724280895 0.261563953204889 no 894 0.261767031359022 1186 3104428
SGTC_3323 9138564 53.9225 µM 0.637345267019679 0.261760816191315 no 895 0.261949985697992 1284 43912313 YNL103W MET4
SGTC_41 0478-0632 82.643 µM 0.636475005851183 0.26206582304575 no 896 0.262233433375581 1275 3750424
SGTC_2992 9074591 71.4286 µM 0.636328942587362 0.262117032762535 no 897 0.262281022181869 1302 17741321
SGTC_214 4373-3496 70 µM 0.636147079723684 0.262180800970364 no 898 0.262340281021996 1357 3779166
SGTC_1086 cerivastatin 2.18 µM 0.635785413446608 0.262307638880418 no 899 0.262458148017294 1269 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.63521726860765 0.262506953150919 no 900 0.262643361082451 1337 1377
SGTC_1246 0422-0085 105 µM 0.634685681378921 0.262693512606084 no 901 0.262816717046171 1282 264295
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.63198834273752 0.263641182281932 no 902 0.263697247291335 1139 4000243
SGTC_2855 9016525 58.44 µM 0.631320154442111 0.263876209518343 no 903 0.26391560572941 1279 43811474
SGTC_416 estradiol valerate 100 µM 0.629722175387429 0.264438712373413 no 904 0.264438185661401 1290 13791 A steroid.
SGTC_2143 5623677 140.463 µM 0.628435048428352 0.264892235850514 no 905 0.26485949162543 1263 5375313
SGTC_3037 9091026 49.47 µM 0.627862096582666 0.265094244423317 no 906 0.265047141492687 1309 25236398 YIL048W NEO1
SGTC_212 3807-4682 38.772 µM 0.627666186379048 0.265163335437485 no 907 0.265111320358696 1375 3125501 YBL034C STU1
SGTC_1594 piperine 70.1 µM 0.626665338369897 0.265516443883079 no 908 0.265439314558106 1287 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1192 1488-0095 21.4 µM 0.625997474007225 0.265752205243422 no 909 0.265658299078315 1303 915875
SGTC_3052 9092717 49.47 µM 0.623711309116673 0.266560041972569 no 910 0.266408597333513 1293 25237534
SGTC_3243 9134147 49.47 µM 0.622492867533963 0.266991095890124 no 911 0.266808916142717 1352 24282180
SGTC_1724 st037281 8.293 µM 0.622135186473133 0.267117701240976 no 912 0.266926489891652 1315 574124 YDL195W SEC31
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.622096440334279 0.267131417704447 no 913 0.266939227750013 1297 7104
SGTC_806 3966-4455 5.86 µM 0.622027126382988 0.267155956321086 no 914 0.266962015594079 1235 714982
SGTC_718 1130-0073 349 µM 0.621262174143508 0.267426841272532 no 915 0.267213568622539 1381 6740020
SGTC_1680 diphenhydramine 100 µM 0.620340997194131 0.267753232291442 no 916 0.267516654529281 1330 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_474 dl-dihydrosphingosine 5 µM 0.620287106443961 0.267772333051712 no 917 0.267534391045144 1348 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1265 0819-1001 68.8 µM 0.620184106364266 0.267808841780039 no 918 0.267568292065901 1290 3106768
SGTC_2327 6189656 200 µM 0.619858442934063 0.267924290786257 no 919 0.267675493829387 1368 5349088
SGTC_1061 3448-9325 110 µM 0.619615491767169 0.268010434280542 no 920 0.267755482497399 1267 723482
SGTC_810 3825-7150 143 µM 0.617696711993213 0.268691267987667 no 921 0.268387639897855 1344 22330411 YGL099W LSG1
SGTC_1749 st037932 54.2 µM 0.617468375107106 0.268772345760981 no 922 0.26846291726161 1310 594497
SGTC_1628 st004252 77.7 µM 0.614955475792223 0.269665436103674 no 923 0.269292062391558 1358 692968
SGTC_2034 5197015 53.07 µM 0.614465721948475 0.269839668711253 no 924 0.269453808812425 1385 780676
SGTC_1904 st060225 78 µM 0.610488053066065 0.271256830570516 no 925 0.270769277509494 1297 66595
SGTC_2191 5911152 200 µM 0.61040279116945 0.271287248202148 no 926 0.270797509826533 1322 2875902
SGTC_3299 9121982 43.1275 µM 0.609949842167251 0.271448868649489 no 927 0.270947517047682 1332 17594604 YPL160W CDC60
SGTC_21 0849-0113 22.993 µM 0.609221033329724 0.271709021549366 no 928 0.271188970261311 1299 1560156
SGTC_3105 9121040 49.47 µM 0.608684283860694 0.271900696975558 no 929 0.271366863081749 1197 41448907
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.608200334595157 0.272073574880652 no 930 0.271527306366931 1286 6708514
SGTC_260 nsc-65238 3.989 µM 0.607439720172794 0.272345394399172 no 931 0.27177956765705 1300 3246252
SGTC_1030 k029-0042 36.7 µM 0.605687123387199 0.272972230128718 no 932 0.272361268114967 1382 6080581
SGTC_1788 fluconazole 20 µM 0.602994544007623 0.273936652666008 no 933 0.273256159401859 1326 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_187 1488-2104 32.728 µM 0.602883702625645 0.273976389669381 no 934 0.273293029241443 1361 2852859
SGTC_154 3389-1638 511.116 µM 0.601857002967625 0.274344600260927 no 935 0.273634663634489 1236 5238686
SGTC_812 4251-0442 148 µM 0.601679698875138 0.274408212470083 no 936 0.273693682974499 1320 5723007
SGTC_1489 4065-0444 182 µM 0.601620370589548 0.274429499578906 no 937 0.273713433029342 1322 2877968
SGTC_1634 st006576 41 µM 0.601556997052411 0.274452239032381 no 938 0.273734530504518 1358 3915356
SGTC_132 0417-1715 25.805 µM 0.600525521627106 0.274822479832653 no 939 0.274078028628017 1390 6769098
SGTC_2203 7227154 166.4 µM 0.600438583185469 0.27485369701709 no 940 0.274106990274505 1323 896304
SGTC_1814 st052110 31.539 µM 0.599814617653481 0.275077797015044 no 941 0.27431489514419 1345 674163
SGTC_834 0312-0008 75.7 µM 0.598784276003981 0.275448045689659 no 942 0.274658374582232 1356 6385573 YIL048W NEO1
SGTC_2462 5162487 171.77 µM 0.595412270445616 0.276661472205032 no 943 0.27578396270688 1322 2259986
SGTC_1830 st055982 50.3 µM 0.59405378383168 0.27715106695693 no 944 0.276238070366461 1322 455313 An antimicrobial agent.
SGTC_2982 9019404 25.97 µM 0.59276396474334 0.277616306104997 no 945 0.276669563510518 1202 22333232
SGTC_2104 5389443 200 µM 0.592619402139533 0.277668473762234 no 946 0.276717945731371 1423 2244536
SGTC_244 nsc-207895 1.295 µM 0.591774445801579 0.277973485112102 no 947 0.277000818666421 1262 42640
SGTC_2199 6590217 200 µM 0.590252553118863 0.278523268262962 no 948 0.277510671922411 1343 703109
SGTC_1636 st007707 68.9 µM 0.590149611997956 0.278560474821067 no 949 0.277545175050552 1399 403051
SGTC_729 4092-0585 94.1 µM 0.589372571451505 0.278841402806793 no 950 0.277805686004516 1320 2169061
SGTC_640 3381-0960 37.1 µM 0.587400796631102 0.279554888207335 no 951 0.278467279462912 1426 1745025
SGTC_466 geldanamycin 89.2 µM 0.585493842564682 0.280245760298523 no 952 0.279107852826909 1279 5288382 HSP90 inhibitor.
SGTC_1669 st015249 58.4 µM 0.585085612292098 0.280393765816603 no 953 0.279245076307022 1421 722793
SGTC_1948 st076329 66.6 µM 0.584210509337269 0.28071116535488 no 954 0.279539345894202 1283 24208413
SGTC_846 0335-0850 148 µM 0.5819955304512 0.281515313138967 no 955 0.280284845731649 1335 6819598
SGTC_2872 9044037 25.97 µM 0.581457998099685 0.281710631621156 no 956 0.280465909158007 1383 6465195
SGTC_3280 9140961 49.47 µM 0.580336681919923 0.282118284745793 no 957 0.280843797593213 1353 4901226
SGTC_3108 9121785 49.47 µM 0.578851869412283 0.28265852315052 no 958 0.281344564346004 1371 17140271
SGTC_2878 9043973 25.97 µM 0.57852672039469 0.282776892617947 no 959 0.281454281355153 1436 6465167
SGTC_36 0335-0881 14.2 µM 0.577008015745411 0.283330087372707 no 960 0.281967020324022 1333 23828853
SGTC_2121 5257820 149.641 µM 0.576196978857289 0.283625723489585 no 961 0.282241023518876 1406 791256
SGTC_170 4197-0004 226 µM 0.57383850826715 0.284486263002172 no 962 0.283038543781385 1408 218692
SGTC_1263 0774-1208 64.8 µM 0.571860876879676 0.285208805012912 no 963 0.283708115385343 1449 906585
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.571839057981684 0.285216781580851 no 964 0.28371550689316 1383 5106787 A p450 inhibitor.
SGTC_1100 amiodarone 5.07 µM 0.569759967316678 0.285977344233324 no 965 0.284420255533255 1411 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.56964925687236 0.286017870797054 no 966 0.284457806456957 1389 442882
SGTC_279 1273-0055 2.93 µM 0.568599648996177 0.286402224826224 no 967 0.284813931543718 1423 2847562
SGTC_1198 1612-1005 86.7 µM 0.568287377359886 0.286516622314659 no 968 0.284919924314157 1454 6998509
SGTC_2676 harmalol 100 µM 0.565346536359996 0.287595031027732 no 969 0.285919040790446 1430 5459187 A monoamine oxidase inhibitor
SGTC_2747 doxorubicin 7.63 µM 0.564959065615143 0.2877372597848 no 970 0.286050803541785 1327 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2355 9061122 103.12 µM 0.563862429413109 0.28813998169905 no 971 0.286423880403539 1409 5302957
SGTC_197 4544-0043 41.561 µM 0.563560487445018 0.288250911679852 no 972 0.286526641927281 1387 896523
SGTC_2922 7999257 32.47 µM 0.560686338162212 0.289307847885998 no 973 0.287505691104693 1379 2988377
SGTC_1718 roemerine 11.9335 µM 0.559127751740648 0.289881761157956 no 974 0.288037268071179 1343 235224 An aporphine alkaloid with mutagenic activity.
SGTC_532 1548-0774 215 µM 0.558581449606973 0.2900830505466 no 975 0.288223701533863 1508 5932993
SGTC_565 1418-0001 44.5 µM 0.554575750646226 0.291560979710358 no 976 0.289592439638138 1448 2862145
SGTC_803 4488-1585 147 µM 0.553317874706212 0.29202580472062 no 977 0.290022881686902 1379 747204
SGTC_1004 4084-0029 199 µM 0.553195080581155 0.292071199516967 no 978 0.2900649175978 1431 716894 YLR208W SEC13
SGTC_3345 9148410 3.559 µM 0.550769560553574 0.292968543430357 no 979 0.290895826595927 1428 4903596
SGTC_1920 st075728 45.7 µM 0.549499499231204 0.293438924279679 no 980 0.291331354071079 1510 3400306
SGTC_585 0kpi-0023 191 µM 0.549094152619908 0.293589122363725 no 981 0.29147041893789 1442 64601
SGTC_590 k048-0076 22.4 µM 0.548855388762316 0.293677611138863 no 982 0.29155234767712 1473 6832814
SGTC_1219 1469-0211 33.1 µM 0.546418334878142 0.294581518016554 no 983 0.29238920483106 1408 6822282
SGTC_42 0133-0086 60.653 µM 0.546083232242625 0.294705908396886 no 984 0.292504362631304 1328 162923 Model of phenazepam hydroxylation.
SGTC_3326 9140064 16.379 µM 0.545676900423763 0.29485677159569 no 985 0.292644026563456 1381 1868434
SGTC_1204 4049-0315 18.3 µM 0.544796563129367 0.295183745967551 no 986 0.29294672135838 1531 588402
SGTC_282 k297-0036 65.7 µM 0.543821713231098 0.295546018812038 no 987 0.2932820827491 1442 5061378
SGTC_2102 5377816 72.7585 µM 0.542738114247227 0.295948944636488 no 988 0.293655063970069 1483 1379702
SGTC_650 1328-0195 38 µM 0.541969564521511 0.29623487522643 no 989 0.293919736379823 1406 2780821
SGTC_1301 naphtanilide LB 4.81 µM 0.541571834573713 0.296382896076445 no 990 0.294056749538308 1523 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1729 st035615 45.989 µM 0.540063316192185 0.296944620556341 no 991 0.294576684026096 1398 17385451
SGTC_1555 citronellol 128 µM 0.53778918494604 0.297792354346151 no 992 0.295361299653107 1465 8842 A terpine precursor.
SGTC_884 0851-0618 334 µM 0.537229467305134 0.298001170896668 no 993 0.295554559523818 1434 9642473
SGTC_3071 9117417 49.47 µM 0.5370641510917 0.298062858974965 no 994 0.29561165119279 1431 45595590 YGL055W OLE1
SGTC_3136 9095672 49.47 µM 0.536955607716626 0.298103365318408 no 995 0.295649139216885 1342 17217380
SGTC_1317 1273-0028 910 nM 0.53690729848661 0.298121394219743 no 996 0.295665824655738 1407 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1135 dihydrocapsaicin 536.708 nM 0.534498179852177 0.299021101450244 no 997 0.296498454209376 1363 107982 A Capsaicinoid.
SGTC_1715 st032160 10.2275 µM 0.533106914736056 0.299541243015748 no 998 0.29697978637127 1449 5289825
SGTC_188 3229-0966 278.469 µM 0.53293914056457 0.299603995149565 no 999 0.297037854882976 1543 5722370
SGTC_1646 st011709 75.6 µM 0.532656152972773 0.299709853752287 no 1000 0.2971358118088 1457 5757843
SGTC_253 dyclonine 31.25 µM 0.52641180387565 0.302050006824713 no 1001 0.299301058046941 1494 3180 An oral anasthetic.
SGTC_1694 st024011 44.9 µM 0.525330719442451 0.302455989502801 no 1002 0.299676652906315 1478 2787533
SGTC_2412 st077135 33.4 µM 0.525125893186024 0.302532936045025 no 1003 0.29974783855031 1519 13258915
SGTC_2310 7668677 200 µM 0.525051368162977 0.302560934841901 no 1004 0.299773740995689 1498 2197143
SGTC_2483 5729050 27.16 µM 0.52368438299194 0.303074712394984 no 1005 0.30024903975093 1568 2865180
SGTC_1923 st058458 19.1 µM 0.522111282953774 0.303666440146081 no 1006 0.300796425530482 1558 3534982
SGTC_1268 0828-0275 2.46 µM 0.521034148020643 0.304071905873355 no 1007 0.301171491653414 1492 745337
SGTC_274 sirtinol 40.1 µM 0.520918292796934 0.304115531605228 no 1008 0.301211845821812 1404 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1420 4'-methoxyflavone 42 µM 0.519777149424935 0.304545382492587 no 1009 0.301609453803183 1476 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1383 3049-0032 20.7 µM 0.519411627722279 0.304683125946215 no 1010 0.301736862238704 1537 712864
SGTC_432 NS 1619 61.3 µM 0.516873767502809 0.305640257821106 no 1011 0.302622140411021 1463 4552 A K+/calcium channel activator.
SGTC_319 1348-1596 45.5 µM 0.515488718192537 0.306163178376064 no 1012 0.303105775605207 1565 5380505
SGTC_917 harmaline 728.087 nM 0.514299105659888 0.306612627999922 no 1013 0.303521443446737 1506 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_236 1509-0011 5.31 µM 0.509931628144473 0.308265203705459 no 1014 0.305049681420787 1489 3107280
SGTC_1490 4089-0339 670 nM 0.509401209797404 0.308466170365961 no 1015 0.305235514260439 1485 742542
SGTC_1054 3429-0080 167 µM 0.50892618507809 0.308646198031014 no 1016 0.305401982488337 1525 1162877
SGTC_1280 0880-0253 10.1 µM 0.508500071897555 0.308807728057214 no 1017 0.305551344345102 1453 6836607
SGTC_1620 st003704 16.5 µM 0.508067121602563 0.308971887769331 no 1018 0.305703135907978 1469 2834414
SGTC_991 3996-0057 64.7 µM 0.50763666369935 0.309135140287056 no 1019 0.305854086748132 1487 715343
SGTC_1835 st008666 49.2 µM 0.507056464704582 0.309355242231522 no 1020 0.306057600245212 1416 690455
SGTC_791 1348-1292 225 µM 0.506031151200564 0.30974436827441 no 1021 0.306417390710787 1489 5437054
SGTC_1257 0669-0121 16 µM 0.505977325280842 0.309764802134714 no 1022 0.306436283804675 1565 4307855
SGTC_27 0485-0001 32.618 µM 0.504301942351308 0.310401119118998 no 1023 0.307024606375688 1441 2054479
SGTC_693 4161-2696 114 µM 0.503814952986114 0.310586186193121 no 1024 0.307195709473422 1563 805759
SGTC_2267 7931562 200 µM 0.500668963809125 0.311782887612346 no 1025 0.30830205916552 1377 934880
SGTC_2245 6637752 200 µM 0.500528989153565 0.311836178842154 no 1026 0.308351324622863 1585 681890
SGTC_553 k007-0256 45.7 µM 0.498927865728294 0.312446039514837 no 1027 0.308915101146728 1515 6287000
SGTC_2622 2-methoxyxanthone 59.94 µM 0.49811161585436 0.312757143348317 no 1028 0.309202686876443 1623 71034 A hepatoprotective.
SGTC_2765 myclobutanil 7.74 µM 0.496715631694291 0.31328951508985 no 1029 0.309694798804038 1481 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1073 triclabendazole 3.09 µM 0.495304948800894 0.3138278878749 no 1030 0.310192439084657 1517 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1379 2144-0755 36.5 µM 0.491669014224628 0.315217331793291 no 1031 0.31147667321413 1542 5392327
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.491108319968591 0.315431830182065 no 1032 0.311674918643346 1557 5377381
SGTC_808 0711-0032 135 µM 0.490977977515116 0.315481702718661 no 1033 0.311721011824446 1599 4252555
SGTC_2671 danthron 100 µM 0.490834222249243 0.315536711256961 no 1034 0.311771851617606 1481 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_893 0958-0369 48.9 µM 0.489912735118335 0.315889419105085 no 1035 0.312097825472117 1608 6819948
SGTC_2318 6029776 164 µM 0.489607605969645 0.316006247122614 no 1036 0.312205796623739 1576 818325
SGTC_2879 9041815 71.43 µM 0.487147788465266 0.316948733829449 no 1037 0.313076801284782 1464 4942971
SGTC_2884 9058502 51.95 µM 0.487048198756553 0.316986917018766 no 1038 0.313112087347843 1474 6471554
SGTC_824 1304-0008 100 µM 0.486511288906783 0.317192804493821 no 1039 0.313302351694048 1516 768245
SGTC_1512 0259-0544 12.2 µM 0.486138241883295 0.317335889227189 no 1040 0.313434577360032 1572 18476
SGTC_2468 5987765 72.9 µM 0.485930141661083 0.317415719353619 no 1041 0.313508348429995 1549 26772094
SGTC_747 3448-8087 38.7 µM 0.484301782605918 0.31804067344212 no 1042 0.314085855512303 1487 5168703
SGTC_1621 st003705 32.4 µM 0.482427762814802 0.318760552308738 no 1043 0.314751051440774 1603 24207032
SGTC_2727 riluzole 51.77 µM 0.482104031079416 0.318884978796293 no 1044 0.314866023192542 1507 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2447 5741742 33.78 µM 0.482049012252968 0.318906127345451 no 1045 0.314885564645579 1581 1776504
SGTC_2829 7992743 58.44 µM 0.481822925178176 0.318993038580142 no 1046 0.314965871143477 1608 16462845
SGTC_2761 levamisole 97.89 µM 0.479709686978568 0.31980587951894 no 1047 0.315716919429243 1611 26879 An alkaline phosphatase inhibitor.
SGTC_3261 9137475 49.47 µM 0.478638768455534 0.320218131083999 no 1048 0.316097816602289 1493 17027690
SGTC_2808 7946468 45.46 µM 0.47711322570066 0.320805774201141 no 1049 0.316640748660028 1558 2970879
SGTC_1236 0330-0013 258 µM 0.47391762010672 0.322038184896544 no 1050 0.317779326862199 1511 4617066
SGTC_2044 5102272 200 µM 0.472260618513946 0.322677993162098 no 1051 0.318370388141351 1514 592666
SGTC_705 1124-0212 310 µM 0.468389908236324 0.324174612170399 no 1052 0.319752891769024 1617 9554485
SGTC_1758 st042942 75.2445 µM 0.468308137036304 0.324206259967904 no 1053 0.319782125147844 1508 669317
SGTC_1080 nisoldipine 24.4 µM 0.468280208851245 0.324217069266794 no 1054 0.319792109790186 1515 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2357 9067248 200 µM 0.468155223645437 0.32426544524024 no 1055 0.319836795015994 1533 9150235
SGTC_2517 totarol 10 µM 0.467746458161838 0.324423680104539 no 1056 0.319982956792783 1465 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_773 4358-1457 44.6 µM 0.467068441213174 0.324686213264227 no 1057 0.320225456105319 1670 1186886
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.466020042915049 0.325092332289618 no 1058 0.320600577057909 1525 521171
SGTC_2930 9013230 14.89 µM 0.465216126499448 0.325403886995195 no 1059 0.320888345647384 1629 2995857
SGTC_3235 9132602 49.47 µM 0.464196949827365 0.325799040419004 no 1060 0.321253323161183 1555 4912240
SGTC_2054 5233173 129 µM 0.463274828840212 0.326156732308208 no 1061 0.321583692880507 1562 6889
SGTC_2346 9031566 143.75 µM 0.46293811732159 0.326287383023215 no 1062 0.32170436223483 1613 4771086
SGTC_1554 st069299 38.7 µM 0.461519268912358 0.326838158252546 no 1063 0.32221305008152 1534 24207999
SGTC_424 splitomicin 100 mM 0.461497672354391 0.326846544625356 no 1064 0.322220795491298 1498 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2859 9028643 45.46 µM 0.45954426061429 0.327605454542261 no 1065 0.322921687831071 1549 17151580
SGTC_1436 4092-1007 8.32 µM 0.45825527121213 0.328106623749704 no 1066 0.323384527494916 1533 2881121
SGTC_2759 disulfiram 3.38 µM 0.456985222488609 0.328600731526719 no 1067 0.323840833574815 1487 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1807 st050092 58.9 µM 0.456697205706803 0.328712825133393 no 1068 0.323944349789619 1518 5008496
SGTC_567 1080-0542 68.4 µM 0.455893281195679 0.329025787029601 no 1069 0.324233360614576 1584 5950415
SGTC_3019 9081971 49.47 µM 0.455665044016249 0.329114659943017 no 1070 0.324315431184949 1653 16451803
SGTC_462 ag-879 158 µM 0.454315443560543 0.329640376007509 no 1071 0.324800901049347 1621 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_37 0566-0070 1.56 µM 0.452844478988221 0.330213751206971 no 1072 0.325330366355392 1646 1626686
SGTC_110 0850-0284 111.64 µM 0.451431442438504 0.330764922077477 no 1073 0.325839313048271 1455 3906265
SGTC_608 k048-0125 159 µM 0.450005782438431 0.33132138895458 no 1074 0.326353135565669 1603 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_944 3370-0224 231 µM 0.449505170354056 0.331516877474052 no 1075 0.326533639573699 1526 4580514
SGTC_2243 6634756 200 µM 0.447416397390722 0.332333036080663 no 1076 0.327287219328231 1658 885676
SGTC_2467 5474540 200 µM 0.446582396437366 0.332659132713277 no 1077 0.327588304069823 1507 5413519
SGTC_2663 amphotericin b 100 µM 0.446361449654342 0.332745544736045 no 1078 0.327668087412785 1547 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2341 7987486 176.74 µM 0.445330384729389 0.333148910419056 no 1079 0.328040506424214 1698 1258686
SGTC_3184 9108758 49.47 µM 0.444342639923627 0.333535509831345 no 1080 0.32839743869406 1562 902885
SGTC_3156 9099931 49.47 µM 0.443899036846825 0.333709191894585 no 1081 0.328557790468497 1605 18111053
SGTC_2168 5727979 200 µM 0.443437815629155 0.333889809706268 no 1082 0.328724544258993 1482 695210
SGTC_1499 4480-0877 67.3 µM 0.442943327800756 0.334083497735878 no 1083 0.328903363425815 1566 2861909
SGTC_2771 fluoxetine 41.05 µM 0.441577829883526 0.334618584803741 no 1084 0.329397364953733 1607 3386 A selective serotonin reuptake inhibitor.
SGTC_1269 0831-0796 3.05 µM 0.441358888131272 0.334704411098086 no 1085 0.329476600105213 1639 927758
SGTC_1205 4161-2785 76 µM 0.441029447552157 0.33483356977528 no 1086 0.329595839276335 1486 3498106
SGTC_1003 4049-0218 100 µM 0.440895158832867 0.334886223885303 no 1087 0.329644449296866 1629 295161
SGTC_1899 st063254 59.6 µM 0.440336669213831 0.335105240410486 no 1088 0.32984664302654 1495 3093813
SGTC_1983 st071813 46.9 µM 0.440320664328053 0.335111517691484 no 1089 0.329852438115548 1572 11838595
SGTC_1087 pterostilbene 9.05 µM 0.438555199480488 0.335804233566928 no 1090 0.330491932486313 1671 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3154 9100113 49.47 µM 0.438444196689381 0.335847806436379 no 1091 0.330532156968499 1529 25237525
SGTC_1991 st073000 8.92 µM 0.438248365095337 0.335924683257322 no 1092 0.330603125943545 1639 4301969 YIL048W NEO1
SGTC_728 3030-5151 22.5 µM 0.437683785082407 0.336146356578159 no 1093 0.330807762688066 1582 3125388
SGTC_1938 st074717 56.4 µM 0.435905426894804 0.336844972689412 no 1094 0.331452673768424 1521 17250979
SGTC_507 nimesulide 162 µM 0.43358513230364 0.337757331621156 no 1095 0.332294866589225 1656 4495 A COX2 inhibitor.
SGTC_2674 ligustilide 100 µM 0.432543851030675 0.338167082517312 no 1096 0.332673094226816 1586 5319022 A signalling regulator.
SGTC_308 4092-1169 104 µM 0.43244091083734 0.338207600570952 no 1097 0.332710494754331 1587 2268590 YDL196W YDL196W
SGTC_2543 pimpinellin 60.67 µM 0.431516567103506 0.338571513300054 no 1098 0.333046404540765 1529 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2026 5148700 152 µM 0.431148639967528 0.338716407630008 no 1099 0.333180147865134 1560 79838
SGTC_60 0986-0278 202 µM 0.430379156889706 0.339019516886327 no 1100 0.33345992732249 1414 3110598
SGTC_88 0180-0332 8.668 µM 0.43033528699966 0.339036800941511 no 1101 0.333475880946376 1620 3101745
SGTC_139 0099-0334 718.624 µM 0.430250273502472 0.339070295903171 no 1102 0.333506797617671 1619 97690
SGTC_3112 9123419 49.47 µM 0.429234581908383 0.339470572457361 no 1103 0.333876259356896 1598 17015854
SGTC_1126 isoteolin 1.0172 µM 0.42830772060846 0.339835999764322 no 1104 0.334213549331574 1501 133323
SGTC_2822 7994718 71.43 µM 0.427342019074049 0.340216900512958 no 1105 0.334565115940124 1617 1018011
SGTC_1934 st074720 32.6 µM 0.426780418145024 0.340438487274168 no 1106 0.334769635234648 1527 17250992
SGTC_737 1950-0117 57.9 µM 0.426727754227074 0.340459269316877 no 1107 0.334788816470348 1660 5393513
SGTC_2776 terbinafine 19.92 µM 0.426092449824854 0.340710008973303 no 1108 0.335020240793693 1564 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3134 9127454 49.47 µM 0.424183379743271 0.341463897141185 no 1109 0.335716040439235 1632 24262820
SGTC_352 k048-0007 5.11 µM 0.424173272071348 0.341467890328889 no 1110 0.335719725889005 1573 6811911
SGTC_1009 4106-0057 9.87 µM 0.423880252271851 0.341583659917303 no 1111 0.335826573358441 1604 2928005
SGTC_275 trichlorophene 5.69 µM 0.423116261307598 0.341885576206789 no 1112 0.336105219320351 1626 62616
SGTC_1955 wogonin 32.4 µM 0.422805948664172 0.342008235403842 no 1113 0.336218423572902 1685 5281703 A flavanone.
SGTC_2227 7312221 64.1025 µM 0.422289548058737 0.342212393224984 no 1114 0.336406843097258 1631 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2395 5646831 180.19 µM 0.422014491087519 0.34232115521391 no 1115 0.336507220142158 1651 6808628
SGTC_479 n-linoleoylglycine 10 µM 0.421535641373329 0.342510531360289 no 1116 0.33668199544319 1585 6433346 An anti-infammatory.
SGTC_847 0342-0274 5.54 µM 0.420636762116591 0.342866128271004 no 1117 0.337010172529995 1706 18097
SGTC_2006 4011487 200 µM 0.420067632707673 0.3430913480564 no 1118 0.337218023495567 1718 45595294
SGTC_2367 9070478 135.38 µM 0.418170298997115 0.34384257630629 no 1119 0.337911304813319 1595 572802
SGTC_1247 0448-0043 5.84 µM 0.417613493573112 0.344063154468361 no 1120 0.338114864749458 1605 3089013 YGL099W LSG1
SGTC_193 1273-0060 1.558 µM 0.416906210939275 0.344343420612884 no 1121 0.338373505208544 1564 2847393 YHR072W ERG7
SGTC_1981 st071826 47 µM 0.416303818895327 0.344582190486762 no 1122 0.338593849228971 1572 11838600
SGTC_1449 4112-4002 201 µM 0.41626462595489 0.344597727522499 no 1123 0.338608187207092 1538 2059539
SGTC_495 decylubiquinone 155 µM 0.416171158242697 0.344634781457132 no 1124 0.338642381503285 1565 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_923 1900-2434 73.3 µM 0.415376029735866 0.344950059003778 no 1125 0.338933325660654 1554 5910570
SGTC_3205 9113483 49.47 µM 0.412992279492904 0.345895887797089 no 1126 0.339806135120114 1722 17018033
SGTC_1841 st054148 70 µM 0.412582704162615 0.346058496898914 no 1127 0.339956187667314 1551 675442
SGTC_1296 1068-0102 11.9 µM 0.412431363925747 0.346118589001478 no 1128 0.340011639289364 1664 767053
SGTC_334 1502-1024 68.5 µM 0.412013560647524 0.346284504699825 no 1129 0.340164741918783 1618 3296216
SGTC_2643 anethole 100 µM 0.411353996487403 0.346546487168235 no 1130 0.34040649066267 1606 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2068 5226020 147 µM 0.410140122823386 0.347028836200424 no 1131 0.340851580766671 1571 1810509
SGTC_2963 9082507 9 µM 0.409679581364088 0.347211903472626 no 1132 0.341020505170245 1664 16459611
SGTC_1055 3448-0672 86 µM 0.409649956227619 0.34722368081677 no 1133 0.341031372620009 1612 748378
SGTC_586 0957-0265 8.15 µM 0.406814965716965 0.348351400083685 no 1134 0.342071947059769 1638 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1575 cyproterone acetate 48 µM 0.406789731018208 0.348361444131078 no 1135 0.342081214779575 1546 9880 An androgen receptor antagonist and liver toxin.
SGTC_3080 9117754 49.47 µM 0.405798118465829 0.348756215094468 no 1136 0.342445470632997 1736 9550191
SGTC_2015 5119600 184 µM 0.401829342395698 0.350337860962618 no 1137 0.343904813007119 1734 2828786
SGTC_2271 7849410 118.62 µM 0.400634156870725 0.350814679506728 no 1138 0.344344746983396 1768 972430
SGTC_2679 rapamycin 1 nM 0.400208062927573 0.350984726307048 no 1139 0.344501638215107 1643 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_478 N-arachidonylglycine 10 µM 0.400020701276913 0.351059508585033 no 1140 0.344570634759087 1652 5283389
SGTC_1966 st070145 16.1 µM 0.399251811747719 0.351366458399792 no 1141 0.344853834991186 1582 3748532
SGTC_2445 5742597 35.57 µM 0.39728157985345 0.352153440494841 no 1142 0.345579914610906 1581 1774255
SGTC_2507 purpurin 79.67 µM 0.395757567324897 0.352762621203567 no 1143 0.346141941366267 1545 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2268 7933382 153.85 µM 0.39575456479279 0.352763821753775 no 1144 0.346143048977887 1607 935025 YOR257W CDC31
SGTC_862 0452-0056 10.2 µM 0.395404631263006 0.352903751287861 no 1145 0.346272145850735 1633 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2282 7944268 200 µM 0.395046377390863 0.353047028529393 no 1146 0.346404330755728 1709 2970414
SGTC_1396 3511-0007 98.6 µM 0.394562267377482 0.353240672789067 no 1147 0.346582982511662 1623 X1396
SGTC_19 0279-0214 38.434 µM 0.394014302571568 0.35345990485219 no 1148 0.346785239860864 1664 3566274 YBR002C RER2
SGTC_1561 5-methoxyflavone 52.9 µM 0.393771338388809 0.353557126548113 no 1149 0.34687493348836 1671 94525
SGTC_760 0568-0725 82.9 µM 0.393294525748609 0.35374795006626 no 1150 0.347050980487572 1756 3916171
SGTC_2961 9083290 32.55 µM 0.391118659315417 0.354619211845117 no 1151 0.347854764441097 1648 17741490
SGTC_146 3448-8650 53.125 µM 0.390409014003477 0.354903533283766 no 1152 0.348117061728584 1671 2891488 YIL048W NEO1
SGTC_1765 st044815 90.4 µM 0.389289806245095 0.355352111309438 no 1153 0.348530888101454 1569 645695
SGTC_1169 aniline yellow 25.8 µM 0.389089913687574 0.355432249285519 no 1154 0.348604817244024 1708 6051 A DNA damaging agent.
SGTC_2797 7859098 81.82 µM 0.389046021864107 0.355449846604066 no 1155 0.348621051159052 1632 972681
SGTC_93 0109-0045 59.227 µM 0.388838717031787 0.355532964407448 no 1156 0.348697729072897 1656 88733
SGTC_131 0141-0277 33.849 µM 0.388481324318625 0.355676275303858 no 1157 0.348829936006053 1736 1547771
SGTC_937 3122-0005 46.7 µM 0.386288372399151 0.356556073043666 no 1158 0.349641555486149 1760 759535
SGTC_492 tmb-8 126 µM 0.385201747552273 0.356992303029612 no 1159 0.350043974351493 1718 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1048 3161-0300 24.5 µM 0.384981621710116 0.357080696249714 no 1160 0.35012551592992 1602 2165101
SGTC_1545 lovastatin 49.4 µM 0.384091994853991 0.35743801084841 no 1161 0.350455132237029 1674 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2745 rifampicin 24.3 µM 0.382434368970323 0.358104122066991 no 1162 0.351069600759399 1767 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3310 9130229 44.1445 µM 0.380260062494597 0.358978514600001 no 1163 0.351876189142415 1731 7761258
SGTC_2618 avocadyne 43.43 µM 0.379419975549752 0.359316551988297 no 1164 0.352188009615012 1736 3015189
SGTC_213 1246-0773 967 nM 0.379349020244022 0.359345108302908 no 1165 0.352214351107314 1683 6251622
SGTC_2800 7887935 81.82 µM 0.379150116855462 0.359425162145484 no 1166 0.352288195905577 1690 2961002
SGTC_623 k072-0108 16.9 µM 0.378994441239538 0.359487822151421 no 1167 0.352345995862291 1675 5382803
SGTC_2014 4013930 200 µM 0.378923794468906 0.359516258981997 no 1168 0.35237222704437 1692 64556
SGTC_2158 5657123 3.6195 µM 0.378496645560589 0.35968821208695 no 1169 0.352530842606898 1682 2858827
SGTC_958 1222-0007 33 µM 0.378456518919959 0.359704366931441 no 1170 0.352545744372067 1749 7312461
SGTC_1794 st048918 76.9 µM 0.377769151891413 0.359981137385929 no 1171 0.352801045869492 1775 672303
SGTC_2228 7354201 200 µM 0.376863728046594 0.360345821130731 no 1172 0.353137439085162 1747 753451
SGTC_2697 mebhydrolin 72.4 µM 0.376853232796706 0.360350049119969 no 1173 0.353141339071589 1801 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1456 k015-0012 13 µM 0.374188098857506 0.361424244186241 no 1174 0.354132188834456 1849 2989616
SGTC_2425 5628681 7.85 µM 0.373550756167322 0.361681290534073 no 1175 0.354369288305922 1770 5714958
SGTC_317 4495-0002 170 µM 0.373004037667649 0.361901837036186 no 1176 0.354572719430348 1646 15991618
SGTC_172 1112-0046 2.638 µM 0.372167757604666 0.362239281534752 no 1177 0.3548839751664 1677 2802135 YIL048W NEO1
SGTC_78 0336-0123 156.75 µM 0.371915585545301 0.362341055642512 no 1178 0.354977850305478 1607 6765896
SGTC_2080 5212524 12.4 µM 0.369881566541165 0.363162320479968 no 1179 0.355735368352133 1799 260183
SGTC_1925 st057770 10.1 µM 0.366919902834333 0.364359260289523 no 1180 0.356839382512087 1568 5989122
SGTC_252 miconazole 1.30953 nM 0.366673736628737 0.364458806737213 no 1181 0.356931199602597 1723 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_611 3453-1652 23.7 µM 0.366650438534174 0.36446822866069 no 1182 0.356939889946406 1761 1560575
SGTC_2200 6600604 21.907 µM 0.366321387367494 0.364601308153278 no 1183 0.357062636140542 1664 2904777
SGTC_1916 st067606 49.2 µM 0.365199865321453 0.365055012356138 no 1184 0.357481109409701 1776 19590279
SGTC_2571 chrysanthemic acid 100 µM 0.363891407354632 0.365584579061982 no 1185 0.357969550681485 1599 2743 An insecticide.
SGTC_1989 st071868 50.2 µM 0.363510925348297 0.36573861809479 no 1186 0.358111626532777 1803 16414057
SGTC_1465 k213-0056 144 µM 0.363281856093791 0.365831367762737 no 1187 0.358197172800776 1664 24048857 YMR208W ERG12
SGTC_1303 1160-0052 261 µM 0.360511412987102 0.366953734018614 no 1188 0.359232361652543 1717 3562476
SGTC_3329 9141233 27.5565 µM 0.358472954344098 0.36778028502653 no 1189 0.359994702098264 1773 4909101 YNL103W MET4
SGTC_1093 fluphenazine 7.97 µM 0.357550569410181 0.368154493801836 no 1190 0.360339837862906 1714 6602611 An atypical antipsychotic.
SGTC_2003 4023581 200 µM 0.357230128357401 0.368284525071706 no 1191 0.360459766379362 1689 16641307
SGTC_3101 9120531 49.47 µM 0.357116353514887 0.368330697216351 no 1192 0.360502351143247 1782 24824904
SGTC_3195 9113082 49.47 µM 0.35686767082797 0.36843162432736 no 1193 0.360595436561758 1823 17018038
SGTC_2687 chenodiol 100 µM 0.35671720673178 0.368492694131068 no 1194 0.360651761395582 1731 5702181 A cholesterol synthesis inhibitor.
SGTC_789 1309-1135 70.6 µM 0.356664990143014 0.368513888381056 no 1195 0.360671308896221 1619 3092424
SGTC_829 1635-0120 117 µM 0.356242346785351 0.368685450286546 no 1196 0.360829540617457 1791 285054
SGTC_1476 4112-3294 3.34 µM 0.355974825653449 0.368794057585431 no 1197 0.36092970907685 1786 704369
SGTC_1040 k898-0338 155 µM 0.355870523226788 0.368836404761715 no 1198 0.360968765823044 1860 20969351
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.355189997014004 0.369112740025363 no 1199 0.361223629017342 1765 688751
SGTC_3202 9113761 49.47 µM 0.353625799448054 0.369748156177161 no 1200 0.361809668481657 1846 4798415
SGTC_1279 0874-0590 65.2 µM 0.353436463274329 0.369825093439838 no 1201 0.361880626858755 1732 3523074
SGTC_2118 5526350 200 µM 0.353331359873003 0.369867804738683 no 1202 0.361920018987253 1741 743594
SGTC_3268 9137683 49.47 µM 0.352731753485317 0.37011149992543 no 1203 0.36214477585566 1698 1953228
SGTC_150 3970-0969 77.2 µM 0.351967067011425 0.370422363490548 no 1204 0.362431480423081 1730 6615640
SGTC_2141 5621638 7.665 µM 0.351937118475759 0.370434540018962 no 1205 0.362442710625122 1819 2856238
SGTC_644 1498-1197 63.3 µM 0.351896717148052 0.370450966667671 no 1206 0.362457860637616 1752 6741615
SGTC_280 3448-3607 3.04 µM 0.349383054346607 0.371473452357375 no 1207 0.363400876706824 1809 626179
SGTC_2936 9038235 15.59 µM 0.348687674951775 0.371756473259716 no 1208 0.363661899098284 1670 4749415
SGTC_2972 9093619 59.92 µM 0.347475243711164 0.372250101099847 no 1209 0.364117156953975 1640 25236256
SGTC_1798 st045719 60.953 µM 0.342936947010218 0.374099676013983 no 1210 0.365822947816887 1800 3980186
SGTC_2549 cedrol 20.94 µM 0.342153414984289 0.374419298078286 no 1211 0.366117720584467 1791 6708665 A sedative which affects the nervous system.
SGTC_633 0437-0093 97.7 µM 0.341164611654294 0.374822778558536 no 1212 0.366489831304517 1690 2831118
SGTC_3031 9088762 49.47 µM 0.340942964340871 0.374913240404009 no 1213 0.36657325981157 1672 205253
SGTC_3149 9097855 49.47 µM 0.340757296655054 0.374989023031023 no 1214 0.366643150365289 1853 25236625 YMR079W SEC14
SGTC_1941 st076221 61.8 µM 0.340252111473013 0.375195245212584 no 1215 0.366833338694919 1850 2828568
SGTC_1347 1493-0251 600 nM 0.339908920422857 0.375335359952037 no 1216 0.366962559340414 1823 3986378
SGTC_2810 7959871 45.46 µM 0.339461975188628 0.37551785910803 no 1217 0.367130868820197 1777 2974535
SGTC_1364 1653-0028 37.6 µM 0.339389954317102 0.375547269676916 no 1218 0.367157992643575 1724 5718652
SGTC_2257 7960413 200 µM 0.338410676551751 0.375947240963591 no 1219 0.367526864770823 1784 2974689 YIL048W NEO1
SGTC_2520 obtusaquinone 4.71 µM 0.337917044359769 0.376148908176924 no 1220 0.367712851393266 1811 5967872
SGTC_1244 0416-0015 52.5 µM 0.337401454976157 0.376359581836931 no 1221 0.367907143989926 1725 96201
SGTC_2041 5107442 45.335 µM 0.336440049264616 0.376752517717686 no 1222 0.368269526435037 1816 793005
SGTC_2491 paeonol 100 µM 0.335888335328485 0.376978066278065 no 1223 0.368477536809099 1710 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2711 st079103 59.1 µM 0.335383693001959 0.377184408058702 no 1224 0.368667833731993 1821 54693780
SGTC_2592 piperlongumine 83.33 µM 0.334967227011428 0.377354722084202 no 1225 0.36882490426649 1654 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.334767137857645 0.377436557154115 no 1226 0.368900375871016 1791 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1623 st003709 20.3 µM 0.334512680140184 0.377540636536929 no 1227 0.368996362050039 1670 16192618
SGTC_3183 9108214 49.47 µM 0.332518347934947 0.378356674261061 no 1228 0.369748943748057 1789 4974831
SGTC_1255 0566-0045 221 µM 0.331232336054684 0.378883170711555 no 1229 0.370234498437536 1784 2788469
SGTC_1928 4'-methoxychalcone 40.3 µM 0.331154478374325 0.378915053065916 no 1230 0.370263901518965 1906 641818
SGTC_2170 morpholine 200 µM 0.33001040625717 0.379383640118263 no 1231 0.370696049575098 1798 121171 Reacts with secondary amines.
SGTC_115 0527-0192 112.043 µM 0.329449956798348 0.379613252749041 no 1232 0.370907806603652 1732 4233931
SGTC_1514 1189-1591 158 µM 0.32906255634492 0.379771993110354 no 1233 0.371054202642101 1805 767698 YMR146C TIF34
SGTC_799 1310-0557 151 µM 0.327926700007676 0.380237535822825 no 1234 0.371483542659374 1763 5354492
SGTC_2082 5219693 150 µM 0.326923506413008 0.380648849666838 no 1235 0.371862870791776 1688 2834649
SGTC_2197 6588183 93.1375 µM 0.324154865467751 0.38178470361722 no 1236 0.372910395401994 1767 884136
SGTC_2053 5265679 138 µM 0.323749727445824 0.381950999930545 no 1237 0.373063759791324 1684 764595
SGTC_2050 5263056 171 µM 0.320173645054779 0.383419809900964 no 1238 0.374418350329101 1869 763468 YGL055W OLE1
SGTC_792 4534-1957 155 µM 0.319258874409582 0.383795805315009 no 1239 0.374765107786317 1778 1717904
SGTC_3061 glucosamine 200 µM 0.319126889790336 0.38385006359558 no 1240 0.374815146891984 1871 91431 and experimental redox chemotherapeutic
SGTC_872 0588-0139 234 µM 0.318410082430013 0.384144779601631 no 1241 0.375086945642221 1730 2047100
SGTC_133 0724-0033 378.92 µM 0.317579240020217 0.384486465052773 no 1242 0.37540206178443 1769 280309
SGTC_1307 1187-1599 12.2 µM 0.317206147598717 0.384639929210289 no 1243 0.375543592755267 1736 1538471
SGTC_1707 st032323 6.317 µM 0.317199600396252 0.384642622433468 no 1244 0.375546076557362 1766 3132057 YMR211W DML1
SGTC_90 0870-0863 4.608 µM 0.31667264188823 0.384859407592421 no 1245 0.375746004900289 1708 1738164
SGTC_356 1634-0012 32.5 µM 0.316631799863752 0.384876211073579 no 1246 0.375761501780319 1924 735457
SGTC_1610 st001799 48.1 µM 0.316617217305177 0.384882210773421 no 1247 0.375767034957154 1689 621897
SGTC_763 3453-1109 128 µM 0.316524133366311 0.384920508933628 no 1248 0.37580235514255 1872 1560353
SGTC_2045 5106652 78.05 µM 0.31603839493318 0.385120377820486 no 1249 0.375986682780376 1839 673349
SGTC_3207 9114163 49.47 µM 0.315796455711583 0.385219940986104 no 1250 0.376078504245848 1920 849233
SGTC_1629 st005085 44.9 µM 0.315717933803504 0.385252256057802 no 1251 0.376108306613245 1672 24207091
SGTC_1793 st048256 72.231 µM 0.315660897342756 0.385275729462785 no 1252 0.376129954812782 1773 672022
SGTC_583 1488-1091 88.9 µM 0.314513339461554 0.385748097099828 no 1253 0.376565593348542 1901 4303273
SGTC_327 1273-0057 3.96 µM 0.313004196658248 0.386369561335643 no 1254 0.37713873688637 1790 3108138
SGTC_1603 st002045 67.8 µM 0.312891062028484 0.386416161887545 no 1255 0.377181714178248 1871 5887985
SGTC_3273 9137859 49.47 µM 0.31162148119011 0.386939218898452 no 1256 0.377664103492068 1799 2377234
SGTC_1906 st060206 94.7 µM 0.310555809676004 0.387378425532689 no 1257 0.378069162907258 1878 5133468
SGTC_400 oxethazaine 37.5 µM 0.309363955123878 0.387869808130849 no 1258 0.378522343030316 1755 4621 A local anesthetic.
SGTC_1887 st057648 70.8 µM 0.308909296150404 0.388057304135577 no 1259 0.378695262563715 1894 688672
SGTC_276 colchicine 750 µM 0.308088071107894 0.38839603378271 no 1260 0.3790076589662 1795 2833 A microtubule depolymerizer.
SGTC_129 0088-0017 176.636 µM 0.308040432414033 0.388415685861808 no 1261 0.379025783291992 1878 182446
SGTC_201 4262-0159 12.803 µM 0.306542942293283 0.38903358104896 no 1262 0.379595644607119 1897 1341029
SGTC_2545 solidagenone 89.61 µM 0.306437720732375 0.389077008201493 no 1263 0.379635695923268 1770 6708572 An anti ulcer agent
SGTC_455 paf C-16 10 µM 0.306327349194575 0.389122562347015 no 1264 0.379677708903693 1757 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2561 acetosyringone 100 µM 0.306295484938451 0.389135714109556 no 1265 0.379689838312802 1750 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.306194461623873 0.389177411659132 no 1266 0.379728294507835 1778 3256 An antibiotic and ribosome inhibitor.
SGTC_770 0389-1121 67.2 µM 0.30473348592236 0.389780574396433 no 1267 0.380284571883377 1890 6753108
SGTC_879 0831-1030 162 µM 0.303712906509069 0.390202077479127 no 1268 0.38067331211989 1738 1549252
SGTC_2088 5278280 127.392 µM 0.302807973845754 0.39057592603961 no 1269 0.381018103150203 1787 791502
SGTC_2772 vinpocetine 57.06 µM 0.301960413187519 0.390926164674033 no 1270 0.381341120407251 1844 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_951 1171-0579 82.7 µM 0.298534111630552 0.392342919059291 no 1271 0.382647772522275 1725 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3099 9120367 49.47 µM 0.296902917425787 0.393017910688826 no 1272 0.383270314384928 1776 24824940
SGTC_2246 7293507 91.5585 µM 0.296876852532014 0.393028699014631 no 1273 0.38328026444917 1932 887656
SGTC_1660 st012960 28.1 µM 0.296750152909235 0.393081141480863 no 1274 0.383328632111103 1793 24207266
SGTC_3306 9127676 59.7925 µM 0.294927294724606 0.393835858295306 no 1275 0.384024710334916 1766 41905287
SGTC_120 rhodamine 6G 52.259 µM 0.294602920186206 0.393970200770625 no 1276 0.384148615572372 1753 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2339 9000433 200 µM 0.293172831254027 0.39456263451183 no 1277 0.384695024834253 1716 2988954
SGTC_695 3505-6186 243 µM 0.291017562100726 0.395455944469341 no 1278 0.385518943962418 1839 1819379
SGTC_656 4090-1979 187 µM 0.28938275501317 0.39613390157193 no 1279 0.386144245120059 1923 22330961
SGTC_2811 7967822 32.47 µM 0.2892613204127 0.396184273257751 no 1280 0.386190704746906 1862 2232244
SGTC_2439 5492030 7.2 µM 0.287975963567978 0.396717551883774 no 1281 0.386682568966707 1922 5722370
SGTC_1492 4158-0558 28.5 µM 0.287875360104521 0.396759299180683 no 1282 0.386721074330778 1899 3967268
SGTC_3321 9137793 26.8275 µM 0.287677996118024 0.396841202511668 no 1283 0.386796617436361 1801 4904192
SGTC_938 3126-1755 342 µM 0.28627423943705 0.397423873255306 no 1284 0.387334043401254 1938 1777771
SGTC_518 1021-0119 62.6 µM 0.285582772763862 0.39771097120899 no 1285 0.387598849762919 1730 1097762
SGTC_2743 auranofin 4.32 µM 0.284723587845732 0.398067783202633 no 1286 0.387927958906986 1871 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1818 st052136 56.3 µM 0.283387008000114 0.39862302253008 no 1287 0.38844009324438 1757 674169
SGTC_2433 5607874 27.82 µM 0.282570806355914 0.398962188404114 no 1288 0.388752930888703 1759 2252428
SGTC_148 3253-0744 288.01 µM 0.282246087473932 0.399097143892941 no 1289 0.388877410760038 1759 6893655
SGTC_898 1000-0849 28.3 µM 0.282020817165651 0.399190774930852 no 1290 0.388963774064928 1925 6751807
SGTC_1306 1185-0270 9.02 µM 0.280301473900934 0.399905591064191 no 1291 0.389623110041548 1895 1548076
SGTC_2250 alverine citrate 130 µM 0.279543536950581 0.400220809691473 no 1292 0.38991386572636 1775 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2864 9034755 47.6 µM 0.279010952992102 0.400442345099407 no 1293 0.390118209577514 1966 4930451
SGTC_3346 9158254 43.5805 µM 0.278235488481693 0.400764967173932 no 1294 0.390415797051565 1809 17639500
SGTC_1400 3771-8998 51.5 µM 0.277872778371164 0.400915891320112 no 1295 0.390555010496834 1859 670767
SGTC_1140 3229-1848 2.98 µM 0.277816505269706 0.400939307956254 no 1296 0.39057661019398 1928 2849525
SGTC_2877 9040724 71.43 µM 0.277241388439724 0.4011786487556 no 1297 0.390797380649436 1961 6463895
SGTC_610 4215-0184 155 µM 0.276170015805205 0.401624610362181 no 1298 0.391208742952089 1834 5605015
SGTC_1569 carminic acid 40.6 µM 0.275179872514081 0.402036874008458 no 1299 0.391589024830413 1950 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_551 k048-0028 34.9 µM 0.275071440348826 0.402082028286647 no 1300 0.391630676405094 1910 6836383
SGTC_2847 9005661 71.43 µM 0.274922096345155 0.402144221572687 no 1301 0.391688045299606 1878 2991449
SGTC_1973 st070275 50.2 µM 0.274682220436098 0.402244121434865 no 1302 0.391780195982566 1931 17118334
SGTC_1658 st012944 20 µM 0.274623281042 0.402268668592805 no 1303 0.39180283905828 1893 24207260
SGTC_1180 1193-0155 285 µM 0.274080077916497 0.402494920692458 no 1304 0.392011541677361 1804 2921347
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.272911803141208 0.402981634917641 no 1305 0.392460506611934 1979 688664
SGTC_3194 9111903 49.47 µM 0.272674468905855 0.403080528985762 no 1306 0.392551731051646 1872 17087251
SGTC_2136 5328288 199.296 µM 0.2721117544341 0.403315029502472 no 1307 0.392768045860593 1789 262395
SGTC_2789 5281112 71.43 µM 0.271584986646024 0.403534581436766 no 1308 0.39297057231345 1764 765948
SGTC_2436 5633522 8.09 µM 0.271016832549339 0.40377141688051 no 1309 0.393189043042295 1958 5724242
SGTC_998 3996-0085 177 µM 0.270112460127336 0.404148477928014 no 1310 0.39353686824694 1927 715391
SGTC_924 2046-0044 21.3 µM 0.26987585662047 0.404247140017012 no 1311 0.393627880924915 1760 3623589
SGTC_1478 0453-0656 35.7 µM 0.267992485367487 0.405032709999195 no 1312 0.394352551523712 1896 5258496
SGTC_322 k048-0136 19.3 µM 0.267690970562732 0.405158509991313 no 1313 0.394468600346225 1876 6823282
SGTC_2182 6325192 200 µM 0.267576187021239 0.405206403312519 no 1314 0.394512781384858 1946 736248
SGTC_606 k015-0008 38.6 µM 0.267554109607187 0.405215615254893 no 1315 0.394521279301308 1949 1970475
SGTC_657 3534-0529 86.7 µM 0.267472533295966 0.40524965394854 no 1316 0.394552679640467 1926 1049549
SGTC_326 k292-0812 17.5 µM 0.266059103572963 0.405839538018636 no 1317 0.395096845367644 1944 3579357
SGTC_3042 9091578 49.47 µM 0.265889553283835 0.405910312925327 no 1318 0.3951621354318 1915 25236497
SGTC_2673 kobusone 100 µM 0.265410080039563 0.40611047474915 no 1319 0.39534678589298 1884 6710676 An epoxy ketone and protein crosslinker.
SGTC_1826 st055655 41.6 µM 0.264589267149528 0.406453189823068 no 1320 0.395662944562316 1838 676168
SGTC_3158 9100007 49.47 µM 0.264577003716543 0.406458310734262 no 1321 0.395667668682104 1778 19297233
SGTC_1883 5-benzylidenerhodanine 20 µM 0.264545230362194 0.406471578588281 no 1322 0.395679908485315 1961 1273210
SGTC_1361 1608-0041 5.61 µM 0.263651243477937 0.406844931811134 no 1323 0.396024334257079 1820 X1361
SGTC_1480 1070-0044 41.2 µM 0.263296114112626 0.406993267006336 no 1324 0.396161177273682 1920 3124987
SGTC_12 0849-0099 9.267 µM 0.262434372777002 0.407353266111321 no 1325 0.39649328769928 1944 6071388
SGTC_2444 5485484 36.41 µM 0.26201516698984 0.407528420886759 no 1326 0.396654874503091 1911 6790631
SGTC_2376 9072922 81.32 µM 0.261304132598216 0.407825551287479 no 1327 0.396928989951011 1886 17087968
SGTC_1723 st034307 2.5525 µM 0.261140472660524 0.407893949786212 no 1328 0.396992090763422 1815 867466
SGTC_1349 flufenamic acid 69 µM 0.258951727390625 0.408808962469108 no 1329 0.397836243137338 1830 3371 A non-steroidal anti-inflammatory.
SGTC_270 tamoxifen 5.46 µM 0.258890115636483 0.40883472669903 no 1330 0.397860012420204 1972 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1862 st057513 3.81 µM 0.257340211921135 0.409482980326002 no 1331 0.398458076403281 1830 5393163
SGTC_419 nsc-638432 893 µM 0.25658036259215 0.409800880993282 no 1332 0.398751367996256 1852 368090
SGTC_2062 5245942 200 µM 0.256199887807767 0.40996008377734 no 1333 0.398898247627816 1917 1376160
SGTC_955 1216-0110 33 µM 0.255954510010924 0.410062765548435 no 1334 0.398992981607453 1795 3619719
SGTC_1859 st055998 20 µM 0.255885971847514 0.410091447403703 no 1335 0.399019443471447 1998 676301
SGTC_1473 k844-0725 134 µM 0.255745756021848 0.410150126430371 no 1336 0.399073580772699 1894 54682906
SGTC_1738 st035555 74 µM 0.255521649400394 0.410243917156485 no 1337 0.399160112323545 1880 5331140
SGTC_3066 9117245 49.47 µM 0.255492542898115 0.410256098877917 no 1338 0.39917135122522 1922 17176980
SGTC_2372 9071633 200 µM 0.254216639876593 0.410790177734179 no 1339 0.399664098014982 1989 21321366
SGTC_2112 5488546 200 µM 0.250409908436315 0.412384612704776 no 1340 0.401135183919341 1860 600757
SGTC_2140 5586273 200 µM 0.250226009637822 0.412461674867862 no 1341 0.401206286065631 1892 854421
SGTC_3265 9137266 49.47 µM 0.248055748947565 0.413371369328204 no 1342 0.402045636472017 2038 17224265
SGTC_1799 st045822 46.1415 µM 0.247496179854879 0.413605996007156 no 1343 0.402262123796968 1974 3674992
SGTC_259 usnic acid 108.925 µM 0.24515306870937 0.414588793941198 no 1344 0.40316895671229 1952 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2313 7726885 200 µM 0.243476917296643 0.415292169890232 no 1345 0.40381798225146 1869 726423
SGTC_871 0574-0004 149 µM 0.243405570023781 0.415322115921219 no 1346 0.403845614645132 1870 9551173
SGTC_1509 1326-1131 80 µM 0.240317045967769 0.416618907134477 no 1347 0.405042240694779 1995 768313
SGTC_1960 st011366 51.8 µM 0.240201391772699 0.416667485057849 no 1348 0.405087067391998 1900 3972846
SGTC_2702 st077768 96.8 µM 0.239739510770121 0.41686150038709 no 1349 0.405266101410881 1850 6484119
SGTC_293 4049-0273 38.5 µM 0.239514328074346 0.416956096804049 no 1350 0.405353393774704 1924 1380311
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.23916955629678 0.417100940404101 no 1351 0.405487054122385 1965 6710655
SGTC_2729 fluphenazine 10.66 µM 0.238517715774421 0.417374818748121 no 1352 0.405739788297031 1887 3372 An atypical antipsychotic.
SGTC_3116 9124943 49.47 µM 0.238127424865106 0.417538823191005 no 1353 0.405891132240725 1778 41905195 YPL160W CDC60
SGTC_672 1441-0018 53.7 µM 0.237879674872768 0.417642937850846 no 1354 0.405987210087021 1845 251141
SGTC_876 0720-0963 56.8 µM 0.236662113550539 0.418154690591891 no 1355 0.406459464518884 2020 765861
SGTC_339 3091-4833 71.4 µM 0.236028653750399 0.418420994708054 no 1356 0.406705217876535 1924 3240077
SGTC_2525 harmine 47.85 µM 0.235870768770632 0.418487374786171 no 1357 0.406766475733884 1947 5280953 A monoamine oxidase inhibitor
SGTC_1630 st005209 31.3 µM 0.235760075607045 0.418533915245128 no 1358 0.406809424979809 2044 3367314
SGTC_2715 st079500 56.4 µM 0.234214019232482 0.41918406683391 no 1359 0.407409415952594 1854 28246688
SGTC_1752 st044819 83.042 µM 0.233557252235427 0.419460319078809 no 1360 0.407664358830866 1844 441209 YML126C ERG13
SGTC_3294 9122953 26.2835 µM 0.233022947750949 0.419685089893249 no 1361 0.407871793240652 1890 16459826
SGTC_509 pifithrin 175 µM 0.232976809105192 0.419704500694729 no 1362 0.40788970697851 1928 4817 A p53 inhibitor.
SGTC_184 1494-0393 24.714 µM 0.232938273689969 0.419720712921828 no 1363 0.407904668842351 1827 3090647
SGTC_1689 st020265 53.493 µM 0.231367349058954 0.42038173201196 no 1364 0.408514714356374 2018 5758320 YPR016C TIF6
SGTC_3241 9133421 49.47 µM 0.231346581285748 0.420390472255647 no 1365 0.408522780704573 1991 17018221
SGTC_2377 9073351 62.6 µM 0.230938590378767 0.420562185665638 no 1366 0.408681255078267 1831 7337946 YHR072W ERG7
SGTC_1965 Pectolinarigenin 58.4 µM 0.23002828508456 0.420945365382185 no 1367 0.409034895329852 1880 5320438 An anti-inflammatory.
SGTC_2894 9048625 32.47 µM 0.230004136296797 0.420955531483111 no 1368 0.409044277789215 2010 4092861
SGTC_680 0417-1641 114 µM 0.229846184791794 0.421022026842595 no 1369 0.409105647520123 1860 2835990
SGTC_882 0843-0131 351 µM 0.228767701956076 0.421476113046029 no 1370 0.409524735609284 2025 5425421
SGTC_3332 9141069 11.198 µM 0.228649144501994 0.421526037056246 no 1371 0.409570812216357 1823 17332883
SGTC_3013 9080133 71.4286 µM 0.228614179679597 0.421540760826471 no 1372 0.409584401312677 1939 17050193
SGTC_200 k038-0079 37.545 µM 0.228551854959822 0.42156700618686 no 1373 0.409608624116639 1939 3436683
SGTC_905 2-aminofluorene 215 µM 0.228083614877916 0.421764196381928 no 1374 0.409790618918234 1884 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2602 kawain 100 µM 0.228079326197816 0.421766002566805 no 1375 0.409792285925404 2020 5369129
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.228028715971214 0.421787317273622 no 1376 0.409811958210771 1894 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_180 1486-1293 102.781 µM 0.227089564783274 0.422182886202866 no 1377 0.410177049097211 2061 4140536
SGTC_1284 0929-0043 16 µM 0.226614667934156 0.422382941883893 no 1378 0.410361692818467 1895 1239883
SGTC_2078 5212016 200 µM 0.22632266379051 0.422505961884736 no 1379 0.410475236250846 2047 1899708
SGTC_1946 st076057 65.1 µM 0.226266127875808 0.422529781079057 no 1380 0.410497220648067 1895 953009
SGTC_2429 5902844 64.44 µM 0.224604806252069 0.423229840016905 no 1381 0.411143362785262 2018 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1321 1326-2144 215 µM 0.22416024478576 0.423417213544056 no 1382 0.411316308200767 2009 3513030
SGTC_2155 5570423 76 µM 0.223234648178531 0.42380738902805 no 1383 0.411676443455864 1892 797402
SGTC_1997 st073024 93.8 µM 0.222999996928013 0.423906315672519 no 1384 0.411767754447103 2019 686268
SGTC_1430 4049-0248 69.1 µM 0.221672328965765 0.424466137492074 no 1385 0.412284486249601 2014 22774488
SGTC_2817 7995342 71.43 µM 0.22094708032703 0.424772008824628 no 1386 0.412566819185783 1854 18879975
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.218662522139002 0.425735809322139 no 1387 0.413456472734632 2049 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1272 0839-0021 27 µM 0.218409062248576 0.42584276545056 no 1388 0.413555202660953 1934 5027250
SGTC_3047 9092122 49.47 µM 0.218245108646205 0.425911954225322 no 1389 0.413619070222153 1894 17173831
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.217156996653303 0.426371197541825 no 1390 0.414042998337851 1950 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1590 st077108 57.8 µM 0.21707477645276 0.426405903069779 no 1391 0.414075035381041 2028 5489485
SGTC_2898 9056270 58.44 µM 0.21413628383351 0.427646626576023 no 1392 0.415220390786647 1942 19154699
SGTC_2717 st081029 62.2815 µM 0.213149618979183 0.42806338848894 no 1393 0.415605131715057 2052 5292846
SGTC_1949 st076024 69.1 µM 0.213016348446606 0.428119687405772 no 1394 0.415657105550579 1812 2921930
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.211658287059673 0.428693471238857 no 1395 0.416186816424177 2036 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_597 k018-0003 82.8 µM 0.210116065264357 0.429345245975162 no 1396 0.416788543542957 2007 6786234
SGTC_3215 9129942 49.47 µM 0.209392358426684 0.429651165936657 no 1397 0.417070978821343 2071 17682944
SGTC_3313 9133968 57.047 µM 0.209253686265582 0.429709789227995 no 1398 0.417125102187334 1966 1494643
SGTC_2277 7947813 106.88 µM 0.208614415755684 0.429980059176193 no 1399 0.417374628015528 2020 1246798
SGTC_2389 9091542 195.52 µM 0.207623000905515 0.430399273107692 no 1400 0.417761671787962 1917 3626624 YOL127W RPL25
SGTC_850 0388-0143 75.9 µM 0.20629979390405 0.430958905555781 no 1401 0.418278369755906 1926 67273
SGTC_839 0122-0028 230 µM 0.205719709186727 0.431204288300084 no 1402 0.418504931067969 1964 759448
SGTC_61 0978-8327 98.565 µM 0.204350106590707 0.431783751712736 no 1403 0.419039958294354 2073 6150059 YHR072W ERG7
SGTC_1815 st051655 58.2 µM 0.204341386966226 0.431787441359147 no 1404 0.419043365045342 2072 5984156
SGTC_964 1287-0107 19.4 µM 0.203741573021376 0.432041262583997 no 1405 0.419277726477329 2034 51516812 YPR165W RHO1
SGTC_1356 1502-0781 85.8 µM 0.20357483579265 0.432111825197104 no 1406 0.419342879729862 1931 567702
SGTC_1902 st060212 70.5 µM 0.202792032458315 0.432443133750457 no 1407 0.419648792863109 2061 688944
SGTC_1649 st011737 51.3 µM 0.202611526528906 0.432519536645717 no 1408 0.419719339999447 1932 1761035
SGTC_2010 4012422 159 µM 0.202444898477091 0.432590067679889 no 1409 0.419784465534841 1976 952393
SGTC_592 k241-0073 46.5 µM 0.201728911108549 0.432893158290692 no 1410 0.420064329714508 2048 4230158
SGTC_1618 st003135 44.5 µM 0.201572867832731 0.432959219523241 no 1411 0.420125329070285 2036 1270615
SGTC_2997 9067075 71.4286 µM 0.201275329025643 0.433085188362339 no 1412 0.420241646194451 1978 27209819
SGTC_798 1287-0182 476 µM 0.200857263694846 0.433262195934501 no 1413 0.420405092633397 2072 1649755
SGTC_2477 5967686 25.23 µM 0.199423900487029 0.433869178929037 no 1414 0.420965583032824 1929 776118
SGTC_1342 1486-1464 234 µM 0.199407588457141 0.433876087446838 no 1415 0.420971962477249 1923 3253938
SGTC_2639 lactacystin 53 µM 0.198334422226863 0.434330642174695 no 1416 0.421391710772244 2028 3870 A proteasome inhibitor.
SGTC_1226 3909-7979 35.4 µM 0.197325963808707 0.434757868146894 no 1417 0.421786231294007 2046 6615510
SGTC_2076 5212012 200 µM 0.197020496092663 0.434887292349564 no 1418 0.421905749285802 2015 604802
SGTC_1488 4013-0813 75.9 µM 0.196000764375978 0.435319394882682 no 1419 0.422304783857927 1944 2910057
SGTC_2260 7964312 200 µM 0.195743431818831 0.435428449563956 no 1420 0.422405494126839 2067 231951
SGTC_44 0929-0055 61.211 µM 0.19536217841562 0.43559002954984 no 1421 0.42255471167047 1942 1379590
SGTC_2022 5136654 200 µM 0.19407311151052 0.436136431802367 no 1422 0.423059317619534 1975 1713771
SGTC_823 0417-1665 178 µM 0.193835705143935 0.436237075568968 no 1423 0.423152264263532 1960 3429856
SGTC_94 0334-0113 514.748 µM 0.193224172708796 0.436496341733414 no 1424 0.423391704183384 1875 6795178
SGTC_1615 st002656 86.5 µM 0.192684829999155 0.436725024885421 no 1425 0.423602902362276 2067 1584458
SGTC_2359 9039622 200 µM 0.192649930080216 0.436739823299612 no 1426 0.423616569382034 2002 6463596
SGTC_3009 9080819 71.4286 µM 0.191809259081552 0.43709631494566 no 1427 0.423945808968084 1936 17027216
SGTC_874 0599-0792 117 µM 0.191808877944203 0.437096476580876 no 1428 0.423945958248409 2104 765305
SGTC_1648 st011736 69.8 µM 0.188294848046649 0.438587172179595 no 1429 0.425322761893475 2050 2855514
SGTC_2485 5633444 17.78 µM 0.186781548369516 0.43922940265685 no 1430 0.425915957289617 1911 5724239
SGTC_2336 9001819 198.65 µM 0.18614859364673 0.439498070378301 no 1431 0.426164117793755 2038 2989602
SGTC_3165 9101544 49.47 µM 0.185903692190888 0.439602030189448 no 1432 0.426260143363742 2035 5002184
SGTC_442 cape 100 µM 0.185851578602931 0.439624152762908 no 1433 0.426280577604026 2081 5281787
SGTC_1439 4092-1168 46 µM 0.185797960196243 0.439646914338962 no 1434 0.426301602104811 2049 2886240
SGTC_1074 carmofur 3.8 µM 0.185657862829793 0.439706388082016 no 1435 0.426356537161109 2066 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2635 hydroquinidine 100 µM 0.184675773119009 0.440123340194314 no 1436 0.426741674776157 1964 442912 An experimental heart treatment.
SGTC_2832 7992762 51.95 µM 0.183764758259572 0.440510176436125 no 1437 0.427099002047573 1772 2985177
SGTC_2540 epiandrosterone 100 µM 0.181782622377777 0.441352029078537 no 1438 0.427876661314567 2136 441302 A steroid.
SGTC_1145 3546-0597 10.2 µM 0.181582507896414 0.441437036483353 no 1439 0.427955188650887 1999 875334
SGTC_3236 9132701 49.47 µM 0.181555767974972 0.441448395642459 no 1440 0.427965681934795 1962 24282524
SGTC_3190 9110366 49.47 µM 0.180237423370137 0.442008489962477 no 1441 0.428483089943764 2098 17123768
SGTC_569 4130-2812 160 µM 0.179217077026349 0.442442060376136 no 1442 0.428883627639578 2122 743552
SGTC_354 2783-3500 4.88 µM 0.178756006139587 0.442638003455805 no 1443 0.42906464540279 1912 6740761
SGTC_1497 4476-2978 41.3 µM 0.176984201017512 0.443391104488463 no 1444 0.429760399717644 2045 1528379
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.176708540691533 0.443508291627256 no 1445 0.429868665976089 1973 15053
SGTC_658 3253-0951 102 µM 0.176667752599301 0.443525631647242 no 1446 0.429884686045877 2010 1184878
SGTC_1374 2889-5571 141 µM 0.17665752974434 0.443529977650964 no 1447 0.429888701227243 1972 2853281
SGTC_842 0271-0008 11.1 µM 0.173625787471999 0.444819148252706 no 1448 0.431079782178147 2064 1221709
SGTC_588 3970-1144 52.9 µM 0.173384881043679 0.444921612749888 no 1449 0.431174454151816 2083 1888707
SGTC_476 mead acid 10 µM 0.172758631383295 0.445187992111288 no 1450 0.431420577701574 1969 5312531 An omega 9 fatty acid.
SGTC_2040 5100729 123 µM 0.172494843241248 0.4453002035266 no 1451 0.431524257548635 2019 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2915 7971052 15.16 µM 0.171277731407614 0.445818000788668 no 1452 0.432002694739949 2104 5741558
SGTC_313 3474-0040 5.03 µM 0.170714267310345 0.446057747308537 no 1453 0.432224221912181 1977 1043375 YIL048W NEO1
SGTC_2946 9065502 71.43 µM 0.169556272592904 0.446550520564833 no 1454 0.432679556954094 2126 16489101
SGTC_3143 9086658 49.47 µM 0.169171105429776 0.446714442992886 no 1455 0.432831028359086 1953 25236626
SGTC_3222 9128301 49.47 µM 0.169055036234047 0.446763842407843 no 1456 0.432876675837998 2012 4911358
SGTC_1797 st048695 56.8 µM 0.167410858296803 0.447463698087029 no 1457 0.43352339102962 2108 592262 YIL048W NEO1
SGTC_1098 clofazimine 15.1 µM 0.166711419049166 0.447761468955951 no 1458 0.433798560090101 2085 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1839 st053978 48 µM 0.166657510125316 0.447784420718233 no 1459 0.433819769938875 2121 3788398
SGTC_840 0245-0196 390 µM 0.166217341489964 0.447971829359155 no 1460 0.43399295637267 2096 3827528
SGTC_2750 bromebric acid 70.15 µM 0.165631388480945 0.448221325977554 no 1461 0.434223522014578 2017 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1041 0206-0046 107 µM 0.165618516295203 0.448226807136797 no 1462 0.434228587320292 2009 50494
SGTC_2706 st078239 82.5 µM 0.163805588682111 0.448998875669864 no 1463 0.434942095989296 2120 15434492
SGTC_744 1594-0068 283 µM 0.163773047737669 0.449012735602328 no 1464 0.434954904977422 2004 668392
SGTC_2493 resveratrol 26.09 µM 0.1619034479311 0.449809144866927 no 1465 0.435690943794033 2014 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1656 st012921 11 µM 0.161669780392712 0.449908696487845 no 1466 0.435782951592491 2091 6732821
SGTC_1447 4239-0816 81.9 µM 0.161495896609761 0.449982779908552 no 1467 0.435851421484827 1951 1341554
SGTC_2464 5717415 7.67 µM 0.161149937189025 0.450130181568888 no 1468 0.435987654995992 1949 5285744
SGTC_1117 retinoic acid 1.10837 µM 0.160875889740106 0.45024694884388 no 1469 0.436095576068218 2131 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1704 st028805 70.8 µM 0.16063653396849 0.450348938069043 no 1470 0.436189839300675 2013 2876101
SGTC_1201 1889-3372 45.9 µM 0.159978751095193 0.450629235479136 no 1471 0.436448906394115 2009 5392199
SGTC_399 oxolinic acid 75 µM 0.159868197968143 0.450676347298104 no 1472 0.436492450306135 2000 4628 A DNA gyrase inhibitor.
SGTC_456 gingerol 170 µM 0.158689405207048 0.451178728687825 no 1473 0.436956792910845 2069 442793 A herb.
SGTC_3255 9139072 49.47 µM 0.15834975040476 0.45132349832725 no 1474 0.437090603735784 2022 17646060
SGTC_231 b-estradiol 524 µM 0.158198427136402 0.45138799829413 no 1475 0.437150221555672 1991 450 A steroid.
SGTC_1781 st038725 66.3 µM 0.157774661881024 0.451568630644204 no 1476 0.437317182721315 1939 4270275 YIL048W NEO1
SGTC_2803 7707263 71.43 µM 0.156515830569267 0.452105273645632 no 1477 0.437813221014311 2002 2199229
SGTC_2113 5491891 107.031 µM 0.155113470335305 0.452703206405237 no 1478 0.438365931462019 1996 789979
SGTC_2095 5432005 200 µM 0.154965016243958 0.452766509970565 no 1479 0.438424448540044 2046 783734
SGTC_2108 5365811 200 µM 0.153576642387204 0.453358596115625 no 1480 0.438971777547656 2079 780283
SGTC_2125 5246583 200 µM 0.153456448918545 0.453409858738117 no 1481 0.439019166090374 2145 835267
SGTC_771 0250-0039 27.3 µM 0.153071797451507 0.453573918148347 no 1482 0.439170828059787 2020 3005115
SGTC_2506 ethyl hematommate 54.16 µM 0.152471864244773 0.453829814137701 no 1483 0.439407390020254 1944 3940691 An allergen.
SGTC_2103 5378138 10 µM 0.15171656852869 0.454152005820711 no 1484 0.439705244328288 2105 244142
SGTC_1783 st039459 87.517 µM 0.151681594795072 0.45416692553908 no 1485 0.439719037207677 2148 729761
SGTC_2746 daunorubicin 9.88 µM 0.151345774931929 0.454310188848013 no 1486 0.43985148097509 2134 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_24 0417-1663 219 µM 0.150804734497614 0.454541013309363 no 1487 0.44006487569686 2009 4329390
SGTC_1530 rhein 70.4 µM 0.150792502127533 0.454546232191784 no 1488 0.440069700534471 2134 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3262 9137218 49.47 µM 0.150686205163782 0.454591583615228 no 1489 0.440111627828006 2141 17650664
SGTC_1151 3909-8316 15.3 µM 0.149253753082364 0.455202794420326 no 1490 0.440676703063764 2046 800431
SGTC_1942 st076330 65.2 µM 0.148543258222458 0.455505993832666 no 1491 0.440957024737006 2100 24208414
SGTC_1108 betulinic acid 729.144 nM 0.148459790663567 0.455541614816482 no 1492 0.440989958328509 2030 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2905 7799065 20.05 µM 0.14785139536266 0.455801267059182 no 1493 0.441230023695449 2143 1296806
SGTC_1273 0849-0096 14.1 µM 0.147441683876983 0.455976135244254 no 1494 0.441391703025294 2025 5286025
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.147206960876655 0.456076320769044 no 1495 0.441484333235583 1925 641818 YHR062C RPP1
SGTC_1324 1418-0026 34.4 µM 0.146351987171509 0.456441268049674 no 1496 0.441821763897909 2060 1372513
SGTC_609 0986-0026 86.3 µM 0.145751812855462 0.45669747565823 no 1497 0.442058658662941 2076 2848610
SGTC_2008 4012253 172 µM 0.145307509789407 0.456887155200345 no 1498 0.442234042851068 2063 603940
SGTC_2137 5261020 140 µM 0.145179228115611 0.456941922371259 no 1499 0.442284682865901 2067 763655
SGTC_1726 st035556 14.5795 µM 0.144320583971063 0.45730852349236 no 1500 0.442623662401334 2131 5919439
SGTC_2983 9022671 12.99 µM 0.142830913467113 0.457944629537508 no 1501 0.443211860982894 2195 6405161
SGTC_2661 dactinomycin 12.96 µM 0.142787181671392 0.457963305141436 no 1502 0.443229130443922 2143 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1103 duloxetine 36.1 µM 0.14241692779814 0.458121425269898 no 1503 0.443375346110844 2134 60835 A selective serotonin reuptake inhibitor.
SGTC_13 0199-0087 65 µM 0.141997755029308 0.458300444634869 no 1504 0.44354088947287 2157 4589825
SGTC_978 1416-0512 87.4 µM 0.141597724476137 0.45847129667401 no 1505 0.443698882213703 2053 6814003
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.141392164550969 0.45855909378523 no 1506 0.443780071934948 2056 6708760
SGTC_691 1548-0686 185 µM 0.138941182899298 0.459606092035783 no 1507 0.444748313658618 2027 46495133
SGTC_1298 1079-1278 263 µM 0.138736061931274 0.459693727405427 no 1508 0.444829360175843 2062 2840950
SGTC_1377 2944-0135 198 µM 0.138417785374814 0.459829710961073 no 1509 0.444955120808584 2076 1894137
SGTC_977 1348-1378 135 µM 0.137450387449375 0.460243060193317 no 1510 0.445337402763555 2160 X977
SGTC_387 norethindrone acetate 66.7 µM 0.136901499319592 0.460477607934425 no 1511 0.445554326855278 2037 541197
SGTC_250 brefeldin a 552.239 µM 0.136736317102294 0.460548195351878 no 1512 0.445619611115592 2072 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_368 fentichlor 4.58 µM 0.136554542093841 0.460625874813609 no 1513 0.445691454977798 2041 7329 A pesticide.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.1357491367305 0.460970073581179 no 1514 0.446009800864659 2032 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_343 4130-2827 29.8 µM 0.13174055193278 0.462683615927429 no 1515 0.447594754616575 2039 1118244
SGTC_2274 7947094 46.08 µM 0.131433860088187 0.462814745854128 no 1516 0.447716052254953 2206 2971028
SGTC_355 1311-2252 105 µM 0.131128653979721 0.462945244547515 no 1517 0.447836767133894 2028 5338538
SGTC_817 1391-0715 46 µM 0.130478529424941 0.46322323523952 no 1518 0.448093919976635 2041 1353946
SGTC_3146 9095609 49.47 µM 0.129461805175544 0.463658018469082 no 1519 0.448496122809339 2097 17173999
SGTC_2788 5282734 71.43 µM 0.129170922908968 0.463782416873262 no 1520 0.448611201792811 2157 743706
SGTC_2733 amorolfine 100 µM 0.128201547417016 0.464197004472207 no 1521 0.448994737757343 2206 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1857 st056007 79.3 µM 0.127988826447748 0.464287987310442 no 1522 0.449078907758751 2187 619834
SGTC_1444 4112-3581 28 µM 0.127973742310609 0.464294439014329 no 1523 0.449084876377488 2106 2877249
SGTC_753 1322-0200 289 µM 0.127950767535768 0.464304265676263 no 1524 0.449093967252508 2108 5403907
SGTC_3315 9136395 68.55 µM 0.127667664878137 0.464425354790168 no 1525 0.449205990167143 2193 16876844
SGTC_805 3852-0218 479 µM 0.126519534761776 0.464916468470507 no 1526 0.449660343396353 1997 6615355
SGTC_854 0422-0053 192 µM 0.126430943801547 0.464954365563404 no 1527 0.449695404532921 2165 3596728
SGTC_661 1304-0007 33.6 µM 0.126000799124637 0.465138375675803 no 1528 0.449865646003798 2069 3117130
SGTC_81 0411-0046 9.971 µM 0.125376841752926 0.46540530949431 no 1529 0.450112610518839 2123 12925265
SGTC_2911 7942208 15.64 µM 0.124855376067266 0.465628408518499 no 1530 0.450319023290162 2049 1243384
SGTC_2889 9059656 51.95 µM 0.124600021980751 0.465737660778218 no 1531 0.450420105497642 2127 3949838
SGTC_515 4092-1064 102 µM 0.124398901886604 0.465823711052045 no 1532 0.450499721381594 2192 717353
SGTC_262 fenpropimorph 62.5 µM 0.124074644794837 0.465962449491134 no 1533 0.450628086766738 2179 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.123372402768705 0.466262928820483 no 1534 0.450906104750829 2021 803109
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.123009663376676 0.466418147367007 no 1535 0.451049722908416 2080 5282362
SGTC_1254 0550-0035 264 µM 0.122888483393741 0.466470002209717 no 1536 0.451097702710458 2137 15121435
SGTC_907 3448-6986 75.5 µM 0.122775489952399 0.466518354413843 no 1537 0.451142441790503 2176 590582
SGTC_247 mechlorethamine 29.705 µM 0.12238753576181 0.4666843717018 no 1538 0.451296054661712 2098 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1019 4262-0212 3.4 µM 0.12097064048372 0.467290752913995 no 1539 0.451857144940393 2196 4677213
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.120258974753588 0.467595349479308 no 1540 0.452139000799152 2090 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3003 9075612 71.4286 µM 0.120208859744399 0.467616799676281 no 1541 0.45215884980489 2119 6501993
SGTC_405 ebelactone b 50 µM 0.119597865665469 0.467878324548313 no 1542 0.452400855270631 2063 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2955 9076254 12.21 µM 0.119372015088816 0.467974999284212 no 1543 0.452490315731939 2181 16459619
SGTC_33 0986-0033 35.816 µM 0.117991078370146 0.468566146426699 no 1544 0.453037363465677 2199 2848082
SGTC_594 1487-1584 10.8 µM 0.116032113215547 0.469404852799094 no 1545 0.453813545507583 2110 5013332
SGTC_1240 0356-0016 42.1 µM 0.115667190179689 0.469561105135606 no 1546 0.453958155058929 2123 4305613
SGTC_1209 2323-2347 50.3 µM 0.115111300016011 0.469799134564155 no 1547 0.454178451663853 2228 5412760
SGTC_3304 9125678 46.087 µM 0.114902706447208 0.469888456091741 no 1548 0.45426111993542 2126 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2290 7904846 200 µM 0.114811765107574 0.469927398415881 no 1549 0.454297161759835 2084 2962154
SGTC_2370 9071495 200 µM 0.114540070130283 0.470043743629142 no 1550 0.454404842012328 2037 21791103
SGTC_2512 diallyl trisulfide 49.23 µM 0.114224301735347 0.470178965172433 no 1551 0.454529993992221 2208 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2342 7990637 118.86 µM 0.113713023858569 0.470397917053266 no 1552 0.454732643973476 2118 2033102 YER133W GLC7
SGTC_1980 st071811 45.7 µM 0.113673835975212 0.47041469941446 no 1553 0.454748176960687 2170 4974850
SGTC_2098 5376439 882.5 nM 0.11362874767458 0.470434008716968 no 1554 0.45476604879483 2164 2844116
SGTC_2691 st077356 60.2 µM 0.112256801843243 0.471021584781593 no 1555 0.455309896187955 2171 2839272
SGTC_3022 9087993 49.47 µM 0.111386185198884 0.471394484711022 no 1556 0.455655057251726 2213 17173644
SGTC_1803 st050068 52.4 µM 0.111099746649228 0.471517176717088 no 1557 0.455768624821873 2222 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1394 3474-0001 65.7 µM 0.111049227711729 0.471538816088651 no 1558 0.455788655018411 2125 5017666 YIL048W NEO1
SGTC_1405 3909-7894 12 µM 0.110858886001275 0.471620348149678 no 1559 0.455864124397337 2208 7104060
SGTC_697 0508-1955 564 µM 0.109647943482151 0.472139077930759 no 1560 0.456344293229392 2215 6243113
SGTC_2013 4024628 200 µM 0.109205742233032 0.472328514898333 no 1561 0.45651965295429 2144 5230760
SGTC_1068 loratadine 26.9 µM 0.108538886716125 0.472614204538006 no 1562 0.456784117781535 2098 3957 A H1 histamine antagonist.
SGTC_386 1509-0011 3.07 µM 0.107239648148376 0.473170855693451 no 1563 0.457299431050509 2165 3107280
SGTC_3069 9117009 49.47 µM 0.107146182268269 0.473210902635605 no 1564 0.457336504933417 2220 41904981
SGTC_1183 1254-0324 198 µM 0.10605225765989 0.473679632046518 no 1565 0.457770445155522 2178 5799357
SGTC_825 1988-2224 89.6 µM 0.105459671010009 0.473933561322207 no 1566 0.458005534680082 2133 1180859
SGTC_980 1473-0395 201 µM 0.104481056117823 0.474352930679227 no 1567 0.458393800510629 2153 768876
SGTC_576 1073-0113 22.7 µM 0.104469256106395 0.474357987554881 no 1568 0.458398482412629 2248 5439563
SGTC_447 ml7 120 µM 0.104145424325704 0.474496766746017 no 1569 0.458526971713277 2235 4216 Selective myosin light chain kinase inhibitor.
SGTC_3023 9089636 49.47 µM 0.103316477865139 0.474852028580468 no 1570 0.458855899078916 2252 17249241
SGTC_423 5-fluorouracil 457 µM 0.101826373797206 0.475490693022191 no 1571 0.459447245595051 2117 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2796 7949634 45.45 µM 0.100107782508161 0.476227366082599 no 1572 0.460129378412436 2179 2971588
SGTC_1812 st052057 4.327 µM 0.0994865912539541 0.476493659443727 no 1573 0.460375966855354 2206 3645418
SGTC_643 k048-0106 28.4 µM 0.0990822532148139 0.47666699743458 no 1574 0.460536481313504 2189 6763920
SGTC_1886 st057356 49.9 µM 0.0983388030313521 0.476985722852006 no 1575 0.460831633562271 2055 24207747
SGTC_2283 7944793 200 µM 0.0982107922067142 0.477040604017207 no 1576 0.460882456476787 2173 2970533
SGTC_1042 0350-0096 82 µM 0.0980688240933201 0.477101469500207 no 1577 0.460938821467504 2044 3122515
SGTC_1397 3532-0190 20.1 µM 0.0966029503380699 0.477729959303714 no 1578 0.461520856712477 2157 5322280
SGTC_2973 9094665 17.96 µM 0.0961660550948961 0.477917287860775 no 1579 0.461694344970666 2228 25237061 YIL048W NEO1
SGTC_1546 5-methoxyflavanone 78.7 µM 0.0959300223725406 0.478018494175186 no 1580 0.461788075063677 2238 147795
SGTC_2473 5854593 8.94 µM 0.0958211559603149 0.478065174487471 no 1581 0.46183130732285 2106 2872951
SGTC_3335 9143315 29.6265 µM 0.0948987528516682 0.478460699351725 no 1582 0.462197623565154 2124 4899691
SGTC_629 3448-6466 76.7 µM 0.0943102194946472 0.478713072551999 no 1583 0.462431366058731 2218 573744
SGTC_441 propafenone 146 µM 0.0924685467991858 0.479502868080603 no 1584 0.463162890073589 2241 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3353 9151644 39.2805 µM 0.0914041741729656 0.479959357822853 no 1585 0.463585722562793 2180 4909158
SGTC_1215 3852-0577 11.2 µM 0.0910755177997535 0.480100317804482 no 1586 0.463716292872607 2219 2884876
SGTC_815 1582-0027 36.9 µM 0.0907907025701263 0.480222476431302 no 1587 0.463829448906947 2182 3128206
SGTC_1442 4112-3290 3 µM 0.0905642108563982 0.480319621147033 no 1588 0.463919435313837 2255 704353
SGTC_2002 4023503 131 µM 0.089135912276063 0.480932260359661 no 1589 0.46448694855221 2279 4736863 YCR052W RSC6
SGTC_2117 5521686 200 µM 0.0890285413190771 0.480978316754894 no 1590 0.46452961374246 2188 803312
SGTC_263 alizarin 107.927 µM 0.0890003822581209 0.480990395527332 no 1591 0.464540803164413 2253 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_855 0428-0020 25 µM 0.088975990597254 0.481000858295203 no 1592 0.464550495576538 2128 6812414
SGTC_1156 4092-0367 4.88 µM 0.0887324984405057 0.481105304622117 no 1593 0.464647252187263 2108 1357585
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0886537117849219 0.481139100554637 no 1594 0.464678560131356 2216 17037758
SGTC_2142 5622915 118.518 µM 0.0883054733914602 0.481288480786944 no 1595 0.464816944407708 2141 5322196
SGTC_2338 7999974 200 µM 0.0867666117793616 0.481948621554817 no 1596 0.465428513721193 2240 315925
SGTC_1796 st049173 110.4 µM 0.0858891770113945 0.482325045745932 no 1597 0.465777257605295 2255 94134
SGTC_1882 5615643 20 µM 0.0856074180461057 0.482445925201928 no 1598 0.465889250681599 2269 2253075
SGTC_3175 9106517 49.47 µM 0.0851804185347379 0.482629118429604 no 1599 0.466058978870307 2159 41468073
SGTC_3355 9151058 44.0485 µM 0.0844789536109552 0.482930071971459 no 1600 0.466337817800834 2272 17015728
SGTC_580 1123-0028 41 µM 0.0842572222218766 0.483025204699421 no 1601 0.466425961565233 2246 1677248 YPR107C YTH1
SGTC_3041 9091929 49.47 µM 0.0841178620635932 0.483084996963493 no 1602 0.466481361551383 2216 25236887
SGTC_1945 st075991 56.6 µM 0.0839513539637117 0.483156437509328 no 1603 0.466547554537944 2084 1084980
SGTC_2628 lathosterol 100 µM 0.083698523170752 0.48326491596718 no 1604 0.466648065682901 2203 6710616
SGTC_3104 9120930 49.47 µM 0.0826921253628232 0.483696728744689 no 1605 0.467048173239199 2163 17014836
SGTC_2427 5545055 42.75 µM 0.0810903960068184 0.484384018281909 no 1606 0.467685031705747 2202 5372858
SGTC_2737 bleomycin 30.5 nM 0.0805100856305658 0.484633036482225 no 1607 0.467915787551155 2242 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_161 4065-0411 162.148 µM 0.0804594309639569 0.484654773298059 no 1608 0.467935930492658 2190 1906281 YLR208W SEC13
SGTC_449 xestospongin c 11.1929 µM 0.0803413936741521 0.484705425369406 no 1609 0.467982868603478 2213 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_679 0422-0091 41.4 µM 0.0803402425192507 0.484705919353332 no 1610 0.467983326368098 2236 627384 YHR062C RPP1
SGTC_2556 citropten 84.59 µM 0.0801433599354144 0.484790406009566 no 1611 0.468061618696544 2248 2775 A potential DNA crosslinker.
SGTC_2434 5670830 169.91 µM 0.0794422096567161 0.485091290567718 no 1612 0.468340448129609 2192 1549830
SGTC_873 0591-4978 488 µM 0.0791412345476993 0.485220450604053 no 1613 0.468460142962142 2254 3305145
SGTC_2566 crystal violet carbinol 226 nM 0.0787586640402612 0.485384628611653 no 1614 0.468612291593802 2042 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1457 k015-0032 57.3 µM 0.0776437535591151 0.485863100279378 no 1615 0.469055718552593 2289 4302660
SGTC_2295 7971645 200 µM 0.077518702201241 0.48591676823053 no 1616 0.46910545691718 2201 2978226 YKL099C UTP11
SGTC_1588 farnesol 29.9 µM 0.0769686505157444 0.486152835431935 no 1617 0.46932424211332 2264 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1419 3993-2473 62.6 µM 0.0769574866772856 0.48615762669785 no 1618 0.469328682669594 2212 704026
SGTC_2971 9092186 9.93 µM 0.0768834165826855 0.486189415950756 no 1619 0.46935814507206 2046 25236400
SGTC_1866 st057638 64 µM 0.0768243652300559 0.486214759553341 no 1620 0.469381633682823 2203 688802
SGTC_769 0302-0231 76 µM 0.0759017141819085 0.48661074920693 no 1621 0.469748646537921 2245 571869 YER009W NTF2
SGTC_620 0109-0052 432 µM 0.0756993812040237 0.486697589629446 no 1622 0.46982913415514 2273 493037
SGTC_2403 6032726 181.2 µM 0.0753905106559405 0.486830156722661 no 1623 0.469952004561645 2211 2881040
SGTC_1144 3486-0183 12.5 µM 0.0740987750533271 0.487384584634209 no 1624 0.470465894974573 2189 6744069
SGTC_1458 k015-0034 6.33 µM 0.0736475207578684 0.487578274016188 no 1625 0.470645428841889 2099 3598957
SGTC_2496 diffractaic acid 79.83 µM 0.0732366175839094 0.487754646259627 no 1626 0.470808913996921 2276 94870 An apoptosis inducer which activates caspases.
SGTC_1513 0337-0559 19 µM 0.072854139097981 0.487918819908118 no 1627 0.470961094304642 2116 775073
SGTC_1982 st072467 71.9 µM 0.0727509636112468 0.487963106923623 no 1628 0.471002146431822 2131 3163533
SGTC_3082 9117008 49.47 µM 0.0726474637355249 0.488007533328889 no 1629 0.471043327938579 2159 41448529
SGTC_318 1488-0629 67.2 µM 0.0723512770377069 0.488134669666861 no 1630 0.471161179204977 2176 3662576
SGTC_2404 5161160 200 µM 0.0722413627498397 0.488181850013625 no 1631 0.471204914215969 2241 2831543
SGTC_1591 genipin 88.4 µM 0.0712774477540486 0.488595614368887 no 1632 0.471588471827148 2262 442424 A DNA cross-linking agent.
SGTC_895 0964-0006 13.7 µM 0.07071734539829 0.488836046205305 no 1633 0.47181135788372 2271 6738897
SGTC_2873 9040596 71.43 µM 0.0707004033518206 0.488843318881374 no 1634 0.47181809990709 2136 6463863
SGTC_2459 5811157 9.22 µM 0.0690801580194061 0.489538854920603 no 1635 0.472462907449753 2290 2870684 YBR192W RIM2
SGTC_1495 4469-0029 237 µM 0.0685803322217065 0.489753425770748 no 1636 0.472661837307354 2264 793680
SGTC_2526 patulin 37.61 µM 0.0682577053035707 0.489891928268066 no 1637 0.47279024592246 2221 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_678 1218-2179 85.9 µM 0.0640458241003529 0.491700178365697 no 1638 0.474466869661888 2305 6820081 YOR116C RPO31
SGTC_1210 3013-0140 750 nM 0.063809521815911 0.491801633357464 no 1639 0.474560948199739 2304 905973
SGTC_3131 9127911 49.47 µM 0.0635556263122913 0.491910642484983 no 1640 0.47466203267018 2239 45595681
SGTC_2276 7947513 42.08 µM 0.0628782359812984 0.492201480537819 no 1641 0.47493173285735 2048 2105100
SGTC_1012 4112-3522 18 µM 0.062558624813214 0.492338707284443 no 1642 0.475058988731803 2294 3112398
SGTC_2656 pseudo-anisatin 100 µM 0.0616147609553181 0.492743965458339 no 1643 0.475434810867652 2271 6708809 A neurotoxin.
SGTC_1521 st012942 49.4 µM 0.0611716065834682 0.492934241198521 no 1644 0.475611271018327 2283 24207259
SGTC_1860 st056228 74.6 µM 0.0610808799088227 0.492973196413129 no 1645 0.475647398168646 2183 688679
SGTC_2533 agelasine 13.65 µM 0.0608599176440429 0.493068071022456 no 1646 0.475735385664282 2284 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_941 3237-0776 460 µM 0.0600159936070077 0.493430430407896 no 1647 0.476071448297514 2282 760008
SGTC_3030 9087619 49.47 µM 0.0597171971620406 0.493558727270027 no 1648 0.476190437411993 2277 25236973
SGTC_406 estrone 100 µM 0.0594737067836916 0.493663277372374 no 1649 0.476287403672014 2304 5870 A steroid.
SGTC_1477 0139-0234 16 µM 0.0592528117082327 0.493758125861421 no 1650 0.476375372918671 2305 620880
SGTC_1216 1165-0504 9.65 µM 0.0586817134073035 0.494003347124083 no 1651 0.476602812410904 2291 6304004
SGTC_2532 xanthone 78.9 µM 0.0584002971390363 0.49412418399541 no 1652 0.476714889047628 2284 7020 An insecticide.
SGTC_1583 clindamycin 39.6 µM 0.0566845657286171 0.494860910356982 no 1653 0.477398234505067 2145 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0557077206562829 0.495280370666143 no 1654 0.477787324430813 2164 61125 An anti-inflammatory.
SGTC_2165 5727197 32.143 µM 0.055487934913402 0.495374748082636 no 1655 0.477874870843319 2208 1361712
SGTC_888 0916-0002 6.97 µM 0.0551105328941659 0.495536807546427 no 1656 0.4780252024314 2298 2802138 YIL048W NEO1
SGTC_1059 3448-6867 171 µM 0.054360785743229 0.495858757164814 no 1657 0.478323860538564 2327 3934407
SGTC_147 4466-0538 29.23 µM 0.0540390291782589 0.495996923788722 no 1658 0.478452034433708 2202 6742687 YHR072W ERG7
SGTC_1408 3909-7976 48.8 µM 0.0534901331956593 0.496232628252155 no 1659 0.478670695982636 2281 24152374
SGTC_1608 st001473 40.5 µM 0.0528403516738092 0.496511656227114 no 1660 0.478929555203182 2216 7292267
SGTC_1840 st055363 71 µM 0.0525811230449386 0.496622974187582 no 1661 0.4790328288946 2181 676033
SGTC_869 0564-0080 44.1 µM 0.0525786136129312 0.496624051789199 no 1662 0.479033828630217 2168 6843321
SGTC_2939 9044578 71.43 µM 0.0517455952637655 0.4969817682818 no 1663 0.479365703057112 2307 2653634
SGTC_75 0159-0059 199.013 µM 0.0514777555912076 0.497096785087063 no 1664 0.479472413406207 2303 5377270
SGTC_2787 5284540 71.43 µM 0.0514469385340889 0.497110018689159 no 1665 0.479484691364173 2244 736958
SGTC_1196 1588-0294 184 µM 0.0506429913442026 0.497455254461584 no 1666 0.479805002309618 2230 6144269
SGTC_2537 larixol 68.93 µM 0.0500087970392405 0.49772759530044 no 1667 0.480057689035651 2311 6708759
SGTC_1927 st060202 13.8 µM 0.0495856633818357 0.49790930136877 no 1668 0.48022628577088 2335 688887
SGTC_2546 rhodinyl acetate 100 µM 0.0493852991029871 0.497995343851353 no 1669 0.480306121741517 2327 6708682
SGTC_2307 7538926 6.34 µM 0.0493659745686974 0.498003642395961 no 1670 0.480313821723472 2243 96582
SGTC_1107 amlodipine 47 µM 0.0478656435053851 0.498647932686002 no 1671 0.480911660250858 2289 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2482 5981709 142.65 µM 0.0476036973170894 0.498760421191645 no 1672 0.481016042669666 2288 877755
SGTC_3210 9128157 49.47 µM 0.0468035404608468 0.49910403603697 no 1673 0.481334903624057 2129 17590849
SGTC_158 k038-0087 26.446 µM 0.0466014343883781 0.499190827443507 no 1674 0.481415444398801 2226 X158
SGTC_2364 9055074 200 µM 0.0456958383993463 0.499579722402962 no 1675 0.481776340411273 2275 6470630
SGTC_677 0929-0063 136 µM 0.0454194820684594 0.499698399686053 no 1676 0.481886476282922 2332 1539583
SGTC_2730 imipramine 71.33 µM 0.0448136888636336 0.499958549012845 no 1677 0.482127906959907 2336 3696 A tricyclic antidepressant.
SGTC_1911 st060208 74.3 µM 0.0447582310455327 0.499982364591291 no 1678 0.482150009251014 2306 688783
SGTC_1028 k015-0029 4.8 µM 0.0446760981434904 0.499982364591291 no 1679 0.482182742794472 2329 4588309
SGTC_2369 9071472 200 µM 0.0431557657092685 0.499329479566443 no 1680 0.48278868303171 2293 17296037
SGTC_556 4058-0063 51.5 µM 0.0430203710515995 0.499271336328035 no 1681 0.482842647567112 2288 6615692
SGTC_2408 sulbentine 18.36 µM 0.0421032381390401 0.498877487598278 no 1682 0.483208199399997 2200 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1065 prochlorperazine maleate 2.48 µM 0.042020343989824 0.498841890019407 no 1683 0.483241240140232 2335 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_95 0471-0001 561.058 µM 0.0414708584782338 0.498605922419991 no 1684 0.48346026221299 2291 4015405
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0398414123971212 0.497906186536864 no 1685 0.484109780053748 2226 689007
SGTC_3070 9117005 49.47 µM 0.0396765716138531 0.497835398993598 no 1686 0.48417549005468 2344 8779016
SGTC_301 4119-0100 24.5 µM 0.0389765724573792 0.497534799287518 no 1687 0.484454533443938 2319 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2079 5212404 121 µM 0.0381641459985012 0.497185921840958 no 1688 0.484778403703124 2337 758462
SGTC_3298 9116858 71.43 µM 0.0379996462246159 0.49711528153302 no 1689 0.484843982048856 2324 2506942
SGTC_1381 2324-0066 62.1 µM 0.0371978129506562 0.496770955651632 no 1690 0.485163641209844 2300 10885928
SGTC_3145 9085516 49.47 µM 0.0369546518422224 0.49666653707238 no 1691 0.485260581804256 2226 25236195
SGTC_35 0133-0054 64.071 µM 0.0362392496044389 0.496359329405893 no 1692 0.485545794936135 2315 99677
SGTC_878 0828-0289 13.7 µM 0.036218074973354 0.49635023663854 no 1693 0.485554236849855 2329 745350 YLR208W SEC13
SGTC_2453 5731132 22.18 µM 0.0352537467919147 0.495936138860517 no 1694 0.485938702548349 2328 1362040
SGTC_1770 st043884 66.3 µM 0.0346825236516342 0.495690848643101 no 1695 0.486166448324476 2347 670149
SGTC_992 3909-8734 162 µM 0.0344423546886573 0.495587717627994 no 1696 0.48626220466748 2328 4288319
SGTC_1950 st077106 7.18 µM 0.0342608090729367 0.495509760274583 no 1697 0.486334588169317 2198 13831864
SGTC_1539 benzyladenosine 56 µM 0.0340290706489746 0.495410249918239 no 1698 0.486426984547319 2344 92208 A nucleotide analog.
SGTC_2576 guaiol 23.12 µM 0.0329480249706288 0.494946044020948 no 1699 0.486858017588623 2347 227829
SGTC_738 1315-0003 72.4 µM 0.0324741478763523 0.494742561176494 no 1700 0.487046966079554 2332 6251474
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.031239885264406 0.494212575312653 no 1701 0.487539115792114 2351 88881 An O-methylated flavonoid and antioxidant.
SGTC_472 calcifediol 10 µM 0.0307913636045149 0.494019984955947 no 1702 0.487717964000519 2271 5283731 A vitamin D metabolite.
SGTC_277 nystatin 15.5 µM 0.0281491458949434 0.492885474983594 no 1703 0.488771598414586 2350 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2541 muurolladie-3-one 83.07 µM 0.0280583711108017 0.492846499264625 no 1704 0.488807798015532 2329 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_6 0844-0013 19.835 µM 0.027295732501412 0.492519049959443 no 1705 0.489111930286228 2360 1584900
SGTC_3303 9125618 40.5795 µM 0.0267901808947751 0.492301987235688 no 1706 0.489313542459754 2321 22695467
SGTC_694 1315-0438 43.2 µM 0.0266495730006462 0.492241616486899 no 1707 0.489369616872846 2329 6793154
SGTC_2343 7990716 14.84 µM 0.0265581882174506 0.492202380038346 no 1708 0.489406061227307 2343 6456862
SGTC_1378 2093-0007 380 nM 0.0265321448611553 0.492191198225436 no 1709 0.489416447363338 2324 3618014
SGTC_2586 curcumin 80 µM 0.0260487264033924 0.491983641817049 no 1710 0.489609236785104 2348 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1956 st077085 54 µM 0.025175258878724 0.491608622824217 no 1711 0.489957585627522 2340 24208685
SGTC_520 3584-0023 682 µM 0.0247151390676451 0.491411075604272 no 1712 0.490141089769796 2227 1340790
SGTC_1708 st033234 31.827 µM 0.0243715448140157 0.491263558681478 no 1713 0.490278122765313 2343 674664
SGTC_1932 st074806 40.9 µM 0.0242734788318605 0.49122145577447 no 1714 0.490317233861376 2325 17251235
SGTC_1951 sophoraflavanone G 9.2 µM 0.0235542298012951 0.490912661855631 no 1715 0.490604090669148 2365 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_781 4335-2806 94.4 µM 0.0231527979048097 0.490740318163174 no 1716 0.490764195158907 2353 845254
SGTC_1604 st002052 72.4 µM 0.0227257575921754 0.490556982103232 no 1717 0.490934514775881 2296 6254834 YHR062C RPP1
SGTC_2164 5685496 200 µM 0.0213732062508049 0.489976320921451 no 1718 0.49147397349839 2369 759046
SGTC_667 1498-1044 59 µM 0.0210011024651584 0.489816577443959 no 1719 0.491622388115259 2330 6739982
SGTC_1233 0325-0408 14.2 µM 0.0190486865042125 0.488978436192111 no 1720 0.492401133114724 2361 12874
SGTC_199 4063-0024 41.6 µM 0.0189776204150391 0.488947929541079 no 1721 0.492429479258363 2356 306215
SGTC_2976 9009005 19.48 µM 0.018951662156967 0.48893678641523 no 1722 0.492439833242921 2376 2993148
SGTC_1218 1348-1416 30.7 µM 0.0179342305928008 0.488500039500732 no 1723 0.49284566066838 2377 6787668
SGTC_2786 7743617 45.45 µM 0.0171936064472834 0.488182124735483 no 1724 0.493141081376299 2356 583674
SGTC_1225 1216-0074 20.6 µM 0.0166522713373067 0.487949760025361 no 1725 0.493357011914958 2371 4241466
SGTC_2099 5377090 177.372 µM 0.0166209774623522 0.487936327449578 no 1726 0.493369494637208 2354 2243829
SGTC_1766 st045414 44.774 µM 0.0163560221207261 0.487822598628821 no 1727 0.493475182157449 2381 253960
SGTC_2779 methotrexate 400 µM 0.0159323279928697 0.487640735198674 no 1728 0.49364418963173 2376 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1690 st023502 41.2 µM 0.0157954654233384 0.487581989837786 no 1729 0.49369878302727 2379 24207482
SGTC_2086 5274770 176.623 µM 0.0152605618341297 0.487352396391064 no 1730 0.493912152957056 2364 689278
SGTC_1863 st057641 20.1 µM 0.0143329601978522 0.486954257507602 no 1731 0.494282171946911 2381 3921635
SGTC_2858 9025781 8.96 µM 0.0137743567916475 0.486714503789124 no 1732 0.494505000454731 2380 4894980 YPL153C RAD53
SGTC_3015 9080845 49.47 µM 0.0133102550370511 0.486515314020048 no 1733 0.494690133288478 2373 5296973
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0128633397747234 0.486323503772348 no 1734 0.494868411413904 2373 688761
SGTC_2850 9015429 58.44 µM 0.0125272688881519 0.486179268578215 no 1735 0.49500247349526 2369 6457570
SGTC_395 anisomycin 6.25 µM 0.0119554427183853 0.485933855892929 no 1736 0.495230582036549 2357 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1562 morin hydrate 59.1 µM 0.0112885163971294 0.485647635471356 no 1737 0.495496629170926 2379 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2416 tofa 880 nM 0.0110605383191854 0.485549797294144 no 1738 0.495587573586731 2366 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2781 5567276 71.43 µM 0.0106550995132426 0.485375802920179 no 1739 0.495749310733372 2380 2853274
SGTC_3284 9108171 64.8615 µM 0.0100648251464895 0.485122491210288 no 1740 0.495984783495043 2369 8687505
SGTC_533 1222-0222 6.71 µM 0.00968519732917513 0.484959580014648 no 1741 0.496136225697089 2379 3982874
SGTC_1131 3454-3128 32.3 µM 0.00571786549157857 0.483257218443498 no 1742 0.497718914131399 2381 710982
SGTC_3092 9117248 49.47 µM 0.00521541745155315 0.483041641716529 no 1743 0.497919358901077 2399 17141857
SGTC_1789 tunicamycin 25 nM 0.00441922852860629 0.482700044825575 no 1744 0.498236988631663 2397 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_821 1114-0266 29.2 µM 0.00424879025736328 0.482626921632361 no 1745 0.498304983025584 2391 3123235
SGTC_1393 3470-5649 58.2 µM 0.00347616975120874 0.482295451342335 no 1746 0.498613211705326 2390 4108395
SGTC_2073 5212005 126 µM 0.00224778564872202 0.481768474264835 no 1747 0.499103264022578 2399 691789
SGTC_2153 5569715 200 µM 0.00177226062173045 0.481564482415021 no 1748 0.49929297067622 2402 2054701
SGTC_843 0310-0051 143 µM 0.000254546896299452 0.48091344254316 no 1749 0.499898450481818 2404 2065037
SGTC_2764 methyldopa 94.69 µM 0.000158026069149693 0.480872040583898 no 1750 0.499936956719873 2404 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_669 0108-0021 26.2 µM -0.00101227887005533 0.480370062704595 no 1751 0.499596159228148 2408 17201
SGTC_1443 4112-3303 14 µM -0.00170393109703847 0.480073407500041 no 1752 0.499320230171439 2409 704433
SGTC_2612 dictamnine 15.46 µM -0.00198720290608938 0.479951913118482 no 1753 0.499207221262802 2415 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2882 9058044 58.44 µM -0.00227013210805461 0.47983056753911 no 1754 0.499094349097879 2411 18076804
SGTC_715 0868-0130 184 µM -0.00272217823333444 0.479636693241991 no 1755 0.498914009349179 2411 2876258
SGTC_1741 st038134 10.228 µM -0.00419630459513194 0.479004501175249 no 1756 0.498325921588694 2424 1272587
SGTC_15 0266-0086 27.098 µM -0.00424351317731423 0.478984256223551 no 1757 0.498307088256955 2415 1712902 YIL048W NEO1
SGTC_2906 7926292 26.41 µM -0.00441609103523817 0.478910248311521 no 1758 0.498238240298209 2414 2966319
SGTC_1212 0520-0165 585 µM -0.00539274430678051 0.478491436229391 no 1759 0.49784861671628 2418 5403258
SGTC_1891 st059073 26.2 µM -0.00572024209208558 0.47835100270731 no 1760 0.497717966020479 2414 688754
SGTC_1645 Cervolide 78 µM -0.00575746982267878 0.478335039345269 no 1761 0.497703114549307 2421 23173 A fragrance.
SGTC_1038 k292-0204 154 µM -0.00595497392933636 0.47825034957653 no 1762 0.497624323161837 2402 4454212
SGTC_1283 0922-0125 16.4 µM -0.00619402081777558 0.478147847575349 no 1763 0.497528959010729 2415 3360884
SGTC_2139 5578692 56.4705 µM -0.00648826047406364 0.478021681201817 no 1764 0.497411576731686 2421 650991 YMR113W FOL3
SGTC_2448 5185112 27.17 µM -0.00663039165929185 0.477960737872414 no 1765 0.497354875812368 2424 5718189
SGTC_523 1934-0222 13.7 µM -0.00729902424169774 0.477674047027699 no 1766 0.497088136479623 2431 1361595
SGTC_3201 9113999 49.47 µM -0.00867768067503999 0.477082954562118 no 1767 0.496538149730415 2442 16649224
SGTC_3006 9075424 71.4286 µM -0.00930898588275766 0.476812302172258 no 1768 0.49628630558019 2435 7465181
SGTC_63 0099-0242 26.702 µM -0.00944070480698487 0.476755833142068 no 1769 0.496233759641347 2421 3898502 YLR359W ADE13
SGTC_2221 6807166 181.081 µM -0.00967305862055089 0.476656222212098 no 1770 0.496141068114352 2430 674925
SGTC_2626 ethyl orsellinate 100 µM -0.0101568198219298 0.47644883670224 no 1771 0.495948084805329 2436 75653 A natural product.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.0104875888623593 0.476307041677666 no 1772 0.495816134080379 2429 4114 Related to psoralen; DNA damaging agent.
SGTC_1638 st008370 60.6 µM -0.0114922361299274 0.475876385063455 no 1773 0.495415362028299 2415 24207134
SGTC_625 k213-0058 121 µM -0.0124245889693052 0.475476743702833 no 1774 0.495043433668393 2436 3655420
SGTC_2958 9077254 16.72 µM -0.0134312590109744 0.475045274914637 no 1775 0.494641864002129 2447 16457351
SGTC_828 2074-0507 139 µM -0.0136052580804422 0.474970700135703 no 1776 0.494572454758982 2454 X828
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0139901914994323 0.474805723495794 no 1777 0.494418903161014 2418 23665772 A membrane-active detergent.
SGTC_1261 0712-0010 12.7 µM -0.0144633217636307 0.474602952943207 no 1778 0.494230170597007 2431 2840123
SGTC_2443 5493264 126.67 µM -0.0148909382301 0.474419694004529 no 1779 0.494059594683598 2444 5340055
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.016282747613977 0.473823259071601 no 1780 0.493504410563912 2418 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1970 st070122 35.8 µM -0.0171810551549311 0.473438336567497 no 1781 0.493146087877966 2464 102928
SGTC_65 0798-0905 34.986 µM -0.0176354623964186 0.473243633639141 no 1782 0.49296483308486 2448 3602145
SGTC_2229 7354935 190 µM -0.0181503180821354 0.473023037685741 no 1783 0.492759468262762 2435 318112
SGTC_619 1652-1634 108 µM -0.0189644358527584 0.472674236295127 no 1784 0.492434738191276 2448 5400454
SGTC_2306 7482397 179.52 µM -0.0193329368156501 0.472516362265174 no 1785 0.492287754527522 2444 891448
SGTC_996 3970-0799 1.8 µM -0.0194939228903783 0.472447393594483 no 1786 0.492223542477126 2412 6615648 YGL040C HEM2
SGTC_732 3970-1727 52.7 µM -0.0197993731297582 0.47231653674123 no 1787 0.492101708978125 2445 1275699
SGTC_2954 9074818 52.69 µM -0.0203247252015739 0.472091479521132 no 1788 0.491892166000272 2464 16648742
SGTC_3176 9106582 49.47 µM -0.0219323929194917 0.471402821371773 no 1789 0.49125094258597 2430 17018027
SGTC_3106 9121286 49.47 µM -0.0223242614456743 0.471234974034778 no 1790 0.491094647934045 2553 15943471
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0238629474799335 0.470575965054256 no 1791 0.490480964744151 2462 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2841 9004761 38.96 µM -0.0245385297622483 0.47028664301075 no 1792 0.490211525326588 2455 2991039
SGTC_1323 1348-1351 11.2 µM -0.0252644374584144 0.469975786301083 no 1793 0.489922019834034 2460 6989654
SGTC_421 streptovitacin 30 mM -0.0262365516989524 0.469559524828762 no 1794 0.489534330934597 2583 91467 include heat shock
SGTC_46 0329-0187a 2.197 µM -0.026980123364728 0.469241148224553 no 1795 0.48923779375872 2445 46494817
SGTC_72 0744-0168 198.391 µM -0.0272792293013334 0.469113084957847 no 1796 0.489118511659778 2499 677577
SGTC_1496 4469-0713 57.4 µM -0.0285145261424218 0.468584222233888 no 1797 0.488625891277035 2455 746691
SGTC_1121 fusaric acid 630.51 nM -0.0285907116194628 0.468551607053868 no 1798 0.488595510055799 2478 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_802 4112-3352 742 µM -0.0299485039761632 0.467970368592413 no 1799 0.488054061300227 2566 704594
SGTC_2606 farnesol 9.78 µM -0.0301660287128893 0.46787725776372 no 1800 0.487967320677178 2469 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3347 9188721 44.724 µM -0.0307448030778106 0.467629523658308 no 1801 0.487736530173072 2487 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1727 st034309 9.9045 µM -0.0313512394603629 0.467369962768282 no 1802 0.487494713644598 2487 870305
SGTC_2987 9018338 71.43 µM -0.0322318415777615 0.466993080907079 no 1803 0.487143581728813 2445 5055682
SGTC_32 0928-0142 34.1 µM -0.0331878291249255 0.466583968947513 no 1804 0.486762401864295 2476 2244242
SGTC_2979 9012552 45.46 µM -0.0345802694161502 0.465988141641583 no 1805 0.486207217407146 2469 17100905
SGTC_711 k292-0785 179 µM -0.0348187414588659 0.465886106702346 no 1806 0.48611213808447 2465 4146315
SGTC_1276 0871-0068 94.2 µM -0.0349809519042742 0.465816703063816 no 1807 0.486047464877501 2503 3414906
SGTC_562 3772-2733 112 µM -0.0351429950350261 0.465747372050852 no 1808 0.485982858745189 2479 2876874 YIL048W NEO1
SGTC_3085 9117376 49.47 µM -0.0351593186495358 0.465740387963406 no 1809 0.485976350587187 2530 16480349
SGTC_1874 staurosporine 7.6 µM -0.0367578986209897 0.465056484133726 no 1810 0.485339021689006 2494 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1721 st082152 9.2685 µM -0.0379405916041353 0.464550571215601 no 1811 0.4848675244568 2477 5296051
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0386925386129515 0.464228945460654 no 1812 0.484567761140335 2462 5355888
SGTC_548 1436-0017 110 µM -0.0393419761467632 0.463951184267737 no 1813 0.484308870190032 2474 9677137
SGTC_2863 9028737 58.44 µM -0.0397984233097541 0.463755974599159 no 1814 0.48412691662681 2492 6460917
SGTC_2316 5844804 197.44 µM -0.0401277415476013 0.463615139827536 no 1815 0.483995642525999 2491 776813
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0401739075001847 0.463595397065758 no 1816 0.483977239814982 2489 4330530
SGTC_159 3970-0959 50 µM -0.0409589304826858 0.463259697584434 no 1817 0.483664318547154 2517 6615653
SGTC_1654 st012436 41.8 µM -0.0412588872712019 0.463131433918329 no 1818 0.483544754173517 2479 4323132
SGTC_1572 epiandrosterone 68.9 µM -0.041410727130389 0.463066507569878 no 1819 0.483484230560289 2499 441302 A steroid.
SGTC_87 0100-0052 35.5 µM -0.0416777879948943 0.462952315392379 no 1820 0.48337778059231 2492 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_89 0302-0250 142.109 µM -0.0428836538690563 0.462436739057799 no 1821 0.482897139543001 2473 4203518 YLR208W SEC13
SGTC_1089 terbinafine 2.25 µM -0.0438609072316172 0.462018953843453 no 1822 0.482507638401798 2496 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1260 0700-1617 7.75 µM -0.0441749271715546 0.461884716171581 no 1823 0.482382483878397 2506 2853078
SGTC_2452 5863136 48.41 µM -0.0453942174932507 0.461363533579899 no 1824 0.481896545005062 2478 2184096
SGTC_2019 4016004 108 µM -0.0460801139968656 0.461070377941062 no 1825 0.481623197950473 2532 45595336
SGTC_2373 9071805 200 µM -0.0465870338686862 0.460853731406378 no 1826 0.481421183142113 2492 10149009
SGTC_2222 6885208 172.143 µM -0.0471172720328298 0.460627131573829 no 1827 0.481209880767027 2492 609514
SGTC_2114 5491910 81.25 µM -0.0479489940522587 0.46027171694755 no 1828 0.480878446330323 2542 2849228
SGTC_488 nitrendipine 139 µM -0.0501197630494127 0.459344245891829 no 1829 0.480013475446443 2487 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2220 6782180 200 µM -0.0503034991962532 0.459265753860732 no 1830 0.479940267673334 2507 833803
SGTC_615 k087-0205 167 µM -0.0504954736321542 0.459183744131118 no 1831 0.479863778161749 2504 9642773
SGTC_2918 7977171 22.06 µM -0.0514728653585006 0.458766238298131 no 1832 0.479474361743822 2492 2236483
SGTC_500 h-89 112 µM -0.0517663916529637 0.458640863509384 no 1833 0.479357417602668 2511 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_984 1492-0255 2.91 µM -0.0524105243939352 0.45836574754867 no 1834 0.479100794195054 2564 1585198
SGTC_2397 5161689 200 µM -0.0527894446395949 0.458203915980384 no 1835 0.478949835866186 2539 2259942
SGTC_981 1488-1094 54.9 µM -0.0532041402255687 0.458026813202753 no 1836 0.478784628433365 2502 3449522
SGTC_1125 tnp00248 1.32998 µM -0.0534066804548641 0.457940317992129 no 1837 0.478703941288946 2536 24207736
SGTC_857 0438-0306 1.35 µM -0.0536456979968191 0.457838247634588 no 1838 0.478608723585555 2565 4686136
SGTC_1351 1496-0003 46.5 µM -0.0539338632385463 0.457715192877895 no 1839 0.478493928478134 2523 3891978
SGTC_885 0865-0106 16.8 µM -0.0546176985553124 0.45742319198598 no 1840 0.478221519198243 2502 2793380
SGTC_726 3448-4391 34.2 µM -0.0557692707290732 0.456931517278237 no 1841 0.477762807618185 2570 1356692
SGTC_1856 st057054 55.7 µM -0.0565939914798091 0.456579435365951 no 1842 0.477434310489964 2533 1266018
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.057088750109588 0.456368234073296 no 1843 0.477237248960368 2536 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_85 0868-0259 160.055 µM -0.0577654231382131 0.456079397598703 no 1844 0.476967740253349 2583 83173
SGTC_2941 9056145 11.23 µM -0.0594945501943576 0.455341429092146 no 1845 0.476279103052526 2506 2119517
SGTC_497 capsazepine 133 µM -0.0603887417036784 0.454959860287861 no 1846 0.475923012556234 2522 2733484 A calcium channel blocker.
SGTC_2072 5231554 129 µM -0.0622226151181525 0.454177441422231 no 1847 0.47519277656105 2558 789545
SGTC_2059 5238311 157 µM -0.06248793012922 0.454064259888957 no 1848 0.475087136758865 2526 703021
SGTC_2463 5473429 200 µM -0.0626477485441836 0.45399608426741 no 1849 0.475023503112412 2601 5399405
SGTC_599 1935-0052 86.5 µM -0.0630498199480985 0.453824573937302 no 1850 0.47486341631215 2519 9557311
SGTC_1429 4049-0205 9.46 µM -0.0646760383738484 0.453130971247813 no 1851 0.474215970738139 2512 22774478
SGTC_2686 alizarin 95.37 µM -0.065342289587367 0.452846847857252 no 1852 0.473950736023505 2562 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2642 cholecalciferol 100 µM -0.065383470913645 0.452829286836688 no 1853 0.473934342108633 2521 9821465 A vitamin D precursor, similar to steriods.
SGTC_2910 7948405 25.97 µM -0.0660166261390873 0.452559301048826 no 1854 0.473682294292537 2542 2971328
SGTC_700 3453-2283 142 µM -0.0670659298493477 0.452111912378994 no 1855 0.473264608423558 2592 565664
SGTC_930 2810-3379 265 µM -0.0671608071684786 0.452071462792374 no 1856 0.473226842996961 2544 1015764
SGTC_2689 tacrolimus 100 µM -0.0681646998427269 0.451643498086492 no 1857 0.472827263515697 2608 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1481 3346-2004 36 µM -0.0688665398232363 0.451344333371198 no 1858 0.472547926308117 2525 2770522
SGTC_2591 skatole 100 µM -0.0693604374552814 0.451133822243749 no 1859 0.472351359690922 2589 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_750 4073-0104 132 µM -0.0701871203599889 0.450781500758304 no 1860 0.472022362753677 2543 22330957
SGTC_2380 9035439 200 µM -0.0702172461747236 0.450768662259111 no 1861 0.47201037387156 2665 6462575
SGTC_345 1362-0200 395 µM -0.0702751556194206 0.450743983557242 no 1862 0.471987328275419 2555 1419823
SGTC_109 0132-0036 33.701 µM -0.0703720903558412 0.450702674254543 no 1863 0.471948752415425 2516 67274 A color developer.
SGTC_1023 4482-3888 16 µM -0.0711709917476531 0.450362238148622 no 1864 0.471630834043277 2515 3303168
SGTC_1728 st035614 33.7865 µM -0.0713019852176848 0.450306421337583 no 1865 0.471578707638896 2668 15945546
SGTC_1203 3992-3522 103 µM -0.0721805059359647 0.449932105804877 no 1866 0.471229129355754 2606 5322312
SGTC_1642 st009582 77.7 µM -0.0722346222616823 0.449909049655568 no 1867 0.471207596274618 2556 6739311
SGTC_3133 9127736 49.47 µM -0.0724461656983277 0.44981892363235 no 1868 0.471123423186614 2518 27243420
SGTC_2504 purpurogallin 52.29 µM -0.0725701712217759 0.449766093488473 no 1869 0.471074082014955 2573 5281571 An antioxidant.
SGTC_2123 5259487 200 µM -0.0731987008877739 0.449498334348373 no 1870 0.470824000078972 2572 2173474
SGTC_1657 st012939 43.4 µM -0.07432100823337 0.449020278856794 no 1871 0.470377480552503 2602 24207257
SGTC_2558 carylophyllene oxide 100 µM -0.0749022434654942 0.4487727262573 no 1872 0.470146245773217 2515 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3111 9122088 49.47 µM -0.0760656718447662 0.448277273080204 no 1873 0.4696834254438 2627 16876704
SGTC_1829 berberine 14.4 µM -0.077566620600351 0.447638204033523 no 1874 0.469086397628447 2699 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_305 1682-2595 20.8 µM -0.0779488860442663 0.447475465952183 no 1875 0.468934356118809 2588 226033
SGTC_1440 4100-1550 40 µM -0.0780296022178395 0.447441104584737 no 1876 0.468902252804425 2543 742806
SGTC_2324 6149169 200 µM -0.0782760974478245 0.447336172504578 no 1877 0.468804215293239 2578 2888231
SGTC_2636 apigenin dimethyl ether 100 µM -0.0791052602989407 0.446983228134435 no 1878 0.46847444975705 2640 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0811351578123116 0.446119352603284 no 1879 0.467667232976836 2533 66535 A nucleotide analog.
SGTC_1128 3448-9350 235 µM -0.081143080056637 0.446115981584999 no 1880 0.467664082845239 2661 619386
SGTC_2152 5568786 200 µM -0.0826614734182731 0.445469957596568 no 1881 0.467060359874014 2537 5399883
SGTC_1053 3366-3204 134 µM -0.082763373752276 0.445426607684878 no 1882 0.467019846343226 2586 3632071 YPR165W RHO1
SGTC_2667 digitoxin 100 µM -0.0839564188048388 0.444919117321916 no 1883 0.466545541066922 2582 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2564 betulinic acid 100 µM -0.0848949835086615 0.444519939682022 no 1884 0.466172439985625 2584 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_135 0933-0004 26.348 µM -0.0854815630475015 0.444270492153773 no 1885 0.465939276186618 2623 21230617 YGL099W LSG1
SGTC_2233 sulbentine 40.3845 µM -0.0855641512563148 0.444235372643693 no 1886 0.465906448531406 2550 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3051 9093778 49.47 µM -0.0856421487310262 0.444202205682728 no 1887 0.465875445841634 2561 17217378
SGTC_2437 5741531 144.16 µM -0.0857754746433926 0.444145512247945 no 1888 0.465822451504278 2629 2262990
SGTC_1245 0418-0076 17.2 µM -0.0861631712764681 0.443980660666903 no 1889 0.465668353428005 2675 6790114
SGTC_325 2810-4341 181 µM -0.0874097500631633 0.443450671632677 no 1890 0.465172909807155 2590 774970
SGTC_1052 3253-3998 198 µM -0.0876818325472708 0.443335007855196 no 1891 0.465064779764475 2552 5450317
SGTC_790 1575-0012 79.1 µM -0.0881812980353069 0.443122694870671 no 1892 0.464866290705702 2552 378741 YLR208W SEC13
SGTC_1153 4055-0057 267 µM -0.0890456334329754 0.442755321456466 no 1893 0.464522821950306 2563 882706
SGTC_3 0833-0587 95.581 µM -0.0912035111854604 0.441838361817749 no 1894 0.463665442530564 2531 5382644
SGTC_1809 st050081 57.6 µM -0.0912592600208918 0.441814676246367 no 1895 0.463643294326672 2685 5036894
SGTC_2259 7964009 200 µM -0.0921471494613103 0.441437473707755 no 1896 0.463290563961665 2737 313134
SGTC_2064 5220758 200 µM -0.0942609923770538 0.440539663063224 no 1897 0.462450917738828 2696 788518
SGTC_1520 flindersine 88 µM -0.0943545169589849 0.440499947475075 no 1898 0.462413772381208 2824 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_647 0140-0236 81 µM -0.094501771627966 0.440437416403627 no 1899 0.462355287594827 2612 990837
SGTC_674 0498-0004 451 µM -0.0946381897799923 0.440379488338598 no 1900 0.462301107448287 2588 4231473
SGTC_561 1550-0330 72.9 µM -0.0949031476337929 0.440266981329568 no 1901 0.462195878178118 2595 6812934
SGTC_913 3487-1245 167 µM -0.0957890691105371 0.439890834399257 no 1902 0.461844049511627 2569 4016153
SGTC_1710 st031758 61.5 µM -0.0959927612008316 0.439804357920415 no 1903 0.461763160869228 2726 5394341
SGTC_1479 0549-0158 134 µM -0.0960210731937225 0.439792338429798 no 1904 0.46175191795263 2613 5440202
SGTC_3161 9100388 49.47 µM -0.0965647774734538 0.439561526584437 no 1905 0.461536014617176 2588 25236368
SGTC_2471 5466956 24.79 µM -0.0975417011545256 0.439146857298941 no 1906 0.461148109682772 2637 724419
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0987499284449685 0.438634100279085 no 1907 0.46066841269878 2768 94937 An inhibitor of serotonin biosynthesis.
SGTC_1748 st037455 53.6035 µM -0.100360595807057 0.43795071285716 no 1908 0.460029025882595 2686 580690
SGTC_1043 0916-0009 19.3 µM -0.101306025733383 0.437549663980894 no 1909 0.459653766481089 2567 3101130
SGTC_174 3553-0389 74.3 µM -0.101353100453066 0.437529696682426 no 1910 0.459635082552019 2686 738071
SGTC_1418 3966-3099 2.4 µM -0.102149644578832 0.437191857242733 no 1911 0.459318948197067 2597 740335
SGTC_2516 gossypol 71.55 µM -0.102184353961034 0.437177136940472 no 1912 0.459305173237087 2671 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1434 4073-0095 163 µM -0.10234240003526 0.43711011045773 no 1913 0.459242450804123 2610 24133745
SGTC_3005 9076496 71.4286 µM -0.103568649905282 0.436590126019004 no 1914 0.458755833792641 2614 21368410
SGTC_2934 9036370 36.88 µM -0.103647134379945 0.436556848834639 no 1915 0.458724690621409 2674 6462800
SGTC_3333 9141820 12.094 µM -0.10393438220722 0.436435060438734 no 1916 0.4586107108994 2631 1939433
SGTC_3237 9133362 49.47 µM -0.105262612582674 0.435871990939383 no 1917 0.458083714476028 2595 43845137
SGTC_2589 lobaric acid 100 µM -0.105772003403194 0.435656082067068 no 1918 0.45788162510161 2645 73157 A novel microtubule depolymerizer.
SGTC_1910 st062352 60.4 µM -0.107902907913228 0.434753091877198 no 1919 0.457036355205573 2577 2245730
SGTC_459 nigericin 15.3 µM -0.109381327568103 0.434126797711817 no 1920 0.456450021660369 2703 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1250 0485-0349 40.2 µM -0.109450805163041 0.434097369384385 no 1921 0.456422469530154 2636 6842794 YDL195W SEC31
SGTC_1182 1222-0449 220 µM -0.109507334480228 0.434073425772997 no 1922 0.456400052341277 2665 658318
SGTC_1008 4106-0037 6 µM -0.110388750922309 0.433700123527787 no 1923 0.456050537034997 2574 2905394
SGTC_3001 9076041 71.4286 µM -0.111440106822897 0.433254924964473 no 1924 0.455633678733274 2626 16004211
SGTC_2331 7980721 200 µM -0.112248371285989 0.432912721459342 no 1925 0.455313238370396 2700 2981221
SGTC_943 3253-1379 105 µM -0.112478288776795 0.432815388029391 no 1926 0.455222091769 2717 668464
SGTC_1817 st052116 64.4 µM -0.113323558423336 0.432457586074243 no 1927 0.454887020312215 2713 4361398
SGTC_746 1095-0025 46.6 µM -0.113393603518914 0.432427938522927 no 1928 0.454859255328731 2696 6749286
SGTC_2563 tomatine 8.54 µM -0.113912642667608 0.432208259921077 no 1929 0.454653521703456 2578 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_45 0kpi-0036 14.9 µM -0.114739389578746 0.431858390108842 no 1930 0.454325845860706 2694 2795021
SGTC_860 0443-0016 25.1 µM -0.11496031215244 0.43176490724595 no 1931 0.454238289867108 2623 5337942
SGTC_601 0986-0029 62.9 µM -0.115001860692215 0.431747326506653 no 1932 0.454221823605797 2629 24747981
SGTC_2067 5224629 34.075 µM -0.116278993963647 0.431206989816505 no 1933 0.453715716530064 2730 2835000
SGTC_3271 9137798 49.47 µM -0.11742865109238 0.430720696505659 no 1934 0.453260190421956 2617 6498326
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.118159567223834 0.43041158095875 no 1935 0.452970613073532 2590 6708630 An antioxidant.
SGTC_1504 k297-0033 30 µM -0.119485695174268 0.429850850268218 no 1936 0.452445286220885 2586 4388117
SGTC_2861 9024595 19.48 µM -0.120740279650809 0.429320500723681 no 1937 0.45194837690838 2579 16482810
SGTC_3060 1327-0027 12.5 µM -0.121602139310145 0.428956241293858 no 1938 0.451607059570378 2691 16000455 YPR107C YTH1
SGTC_1908 st060353 56.5 µM -0.121614591732548 0.428950978800413 no 1939 0.451602128370487 2740 4227716
SGTC_540 1187-0821 17.3 µM -0.122400537900161 0.428618857248043 no 1940 0.451290906266024 2629 847520
SGTC_2880 9042983 58.44 µM -0.123398023513198 0.428197417128415 no 1941 0.450895961060532 2757 6464714
SGTC_2624 nerol 100 µM -0.123657267721333 0.428087899201 no 1942 0.450793323656252 2589 637566 A natural product oil.
SGTC_3197 9113331 49.47 µM -0.123880763749128 0.427993487567274 no 1943 0.450704841958879 2756 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_435 c-PAF 6.7 µM -0.124200527773966 0.427858416523584 no 1944 0.450578252186053 2629 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1943 st076331 65.2 µM -0.126436508332161 0.426914156407396 no 1945 0.449693202278972 2622 24208415
SGTC_2575 plumbagin 510 nM -0.126861536053306 0.426734713339307 no 1946 0.449524995194666 2613 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2899 9053889 58.44 µM -0.128325998680307 0.426116546096499 no 1947 0.448945495613049 2625 6470052
SGTC_195 4234-0266 16.654 µM -0.128867480604317 0.425888025960495 no 1948 0.448731254392592 2664 2303354
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.130734388634385 0.425100331157443 no 1949 0.447992713801853 2691 4213774
SGTC_2029 5175081 200 µM -0.13224280703807 0.424464110196263 no 1950 0.447396121651878 2634 1380876
SGTC_367 0335-0881 7.1 µM -0.13281233250823 0.424223946729757 no 1951 0.44717090041801 2754 23828853
SGTC_291 SEC14.278 35.5 µM -0.133184608073371 0.424066976869925 no 1952 0.447023691688081 2685 1068044
SGTC_701 4424-0219 185 µM -0.13349395774372 0.423936548853656 no 1953 0.446901371262966 2707 2911779
SGTC_2625 euphol 100 µM -0.133915246622311 0.42375893842709 no 1954 0.446734796910681 2735 6708538 A triterpene alcohol.
SGTC_559 1550-0661 158 µM -0.133980029680329 0.423731628026228 no 1955 0.44670918302534 2720 5830875
SGTC_1482 3346-2049 8.48 µM -0.13526425796379 0.4231903155096 no 1956 0.446201471664984 2733 3826804
SGTC_412 gemfibrozil 100 µM -0.135713892669942 0.423000825086167 no 1957 0.44602373228806 2653 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1987 st072290 61.9 µM -0.135729742030256 0.422994145984359 no 1958 0.446017467276699 2691 54697379
SGTC_3117 9124945 49.47 µM -0.135867709378218 0.422936005900235 no 1959 0.445962931449404 2622 17592065
SGTC_2035 5154463 94.595 µM -0.136754979627384 0.422562146236277 no 1960 0.445612235131807 2743 2769623
SGTC_377 3970-0964 33.1 µM -0.138277924455096 0.421920601888466 no 1961 0.445010385814276 2649 16481235
SGTC_2131 toluylene red 5.2905 µM -0.139860061263164 0.421254342161504 no 1962 0.444385278777051 2689 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1299 1079-1439 3.74 µM -0.140584432688814 0.420949374433472 no 1963 0.444099123501276 2670 323161
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.141585302701094 0.42052807606826 no 1964 0.443703788358074 2689 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1406 3909-7906 11.9 µM -0.14252757273125 0.420131527489346 no 1965 0.443331650897194 2700 X1406
SGTC_2669 eugenol 100 µM -0.142762184609761 0.420032805104227 no 1966 0.44323900170333 2653 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_469 w7 172 µM -0.142819459795852 0.420008705029635 no 1967 0.443216383968294 2649 45115570 A P450 inhibitor.
SGTC_222 nsc-310342 10.666 µM -0.143115164462914 0.419884284113739 no 1968 0.443099614358445 2655 432556
SGTC_3181 9108277 49.47 µM -0.143484841692496 0.419728749711198 no 1969 0.442953640976709 2679 17097298
SGTC_445 e6 berbamine 66 µM -0.14369250152499 0.41964138643091 no 1970 0.442871646332389 2747 6610268 A calcium/calmodulin antagonist.
SGTC_1424 4048-1941 275 µM -0.144968408517138 0.419104694595059 no 1971 0.442367907304913 2772 X1424
SGTC_892 0929-0076 29 µM -0.145366360740552 0.418937332485872 no 1972 0.44221081137584 2675 5751038
SGTC_73 0327-0325 16.231 µM -0.145537614218105 0.418865314927826 no 1973 0.442143210015306 2849 53298
SGTC_84 0443-0269 128.823 µM -0.147482197266715 0.41804774691674 no 1974 0.441375715296383 2672 6150058
SGTC_8 0354-0001 70 µM -0.147578130258011 0.418007422600143 no 1975 0.441337857806932 2668 4993152
SGTC_587 k089-0003 57 µM -0.148151310312243 0.417766511007942 no 1976 0.441111678209229 2652 9659696
SGTC_2725 haloperidol 53.21 µM -0.148925154189949 0.417441307973776 no 1977 0.440806346186377 2675 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3187 9109394 49.47 µM -0.149329911666666 0.417271233659253 no 1978 0.440646656892437 2703 17098090
SGTC_2435 5706476 10.6 µM -0.149525825937522 0.417188918351832 no 1979 0.440569366141941 2759 5725375
SGTC_2742 clothiapine 36.27 µM -0.149612841463989 0.417152359086564 no 1980 0.440535038100958 2680 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1787 fluconazole 80 µM -0.149957610215643 0.417007512761281 no 1981 0.440399029576686 2702 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_813 k007-0158 173 µM -0.151471821454456 0.416371486844069 no 1982 0.439801768782872 2758 6523916
SGTC_2720 fluspirilene 36.88 µM -0.152317267380518 0.416016462745442 no 1983 0.439468353211934 2763 3396 An atypical antipsychotic.
SGTC_928 2764-0428 58.7 µM -0.152549145610433 0.415919103181662 no 1984 0.439376915692968 2803 662578
SGTC_2466 5983409 37.09 µM -0.152618789363024 0.415889862610932 no 1985 0.439349453410076 2722 2879657
SGTC_3287 9117173 37.0625 µM -0.152896569143028 0.415773238846832 no 1986 0.439239920763083 2679 2789709
SGTC_2769 toremifene 3.73 µM -0.153203921373483 0.415644207955125 no 1987 0.439118732686042 2841 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2793 7325131 81.82 µM -0.153618391653854 0.415470221767613 no 1988 0.438955317316248 2761 4176441
SGTC_3350 9150499 3.57 µM -0.154334442890407 0.415169677097484 no 1989 0.438673020572285 2676 4910996 YPR165W RHO1
SGTC_1624 st003710 6.25 µM -0.154865451958565 0.414946831308972 no 1990 0.438463695171643 2842 24207033
SGTC_505 gw-5074 63.9 µM -0.155965410293697 0.414485304696302 no 1991 0.438030143051328 2794 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_9 0092-0002 10.449 µM -0.156651431799772 0.414197519716074 no 1992 0.437759783089344 2703 759368
SGTC_995 3931-2021 34.6 µM -0.156891077029009 0.414096999754302 no 1993 0.437665346134292 2780 730143
SGTC_2162 5663267 200 µM -0.157575658568966 0.413809880846159 no 1994 0.437395592778944 2715 6456493
SGTC_3096 9117468 49.47 µM -0.158101322750191 0.413589444395168 no 1995 0.437188479159038 2725 41316311
SGTC_894 0960-0238 55.9 µM -0.161395488169539 0.412208663971553 no 1996 0.435890960004577 2673 6741907 YDL195W SEC31
SGTC_2052 5265182 7.135 µM -0.161668556487566 0.412094253328285 no 1997 0.435783433520609 2823 1239884
SGTC_563 tetrahydrosecaminediol 614 µM -0.162492035348912 0.41174927598382 no 1998 0.435459199899707 2821 334274 A psychoactive constituent of the cannabis plant.
SGTC_1193 1488-0126 41.5 µM -0.162543469815264 0.41172773096891 no 1999 0.435438949714165 2713 1384710
SGTC_961 1252-1571 372 µM -0.163963901580796 0.411132841866698 no 2000 0.434879780762484 2824 6813498
SGTC_761 k216-0224 480 µM -0.164777844241461 0.410792047630141 no 2001 0.434559421689403 2706 1340404
SGTC_2886 9058944 51.95 µM -0.164855049479464 0.410759725626354 no 2002 0.434529036766129 2678 4949929
SGTC_1469 k284-2957 126 µM -0.165332626952066 0.4105598011022 no 2003 0.434341089793438 2727 23884841
SGTC_529 4076-0302 30.3 µM -0.165629576081402 0.410435503322369 no 2004 0.434224235207313 2718 5816522
SGTC_1972 st070201 17.4 µM -0.166827241513021 0.409934272678309 no 2005 0.433752991712777 2802 2829099
SGTC_3297 9117502 71.43 µM -0.167249618603122 0.409757540216111 no 2006 0.433586822099327 2679 7453720
SGTC_2947 9072639 7.68 µM -0.16732902116775 0.409724318370415 no 2007 0.433555585224697 2769 16488146
SGTC_1409 3909-8004 61.9 µM -0.167468913284366 0.409665789415855 no 2008 0.43350055284197 2737 2119279
SGTC_1696 st025591 34.7925 µM -0.168169757882475 0.409372595920408 no 2009 0.433224865898639 2713 2787147
SGTC_2621 lithochol-11-enic acid 100 µM -0.168698460984967 0.409151450160579 no 2010 0.433016914693346 2709 6708711
SGTC_1730 st033808 45.1 µM -0.168782015779117 0.409116503532576 no 2011 0.432984052348573 2700 1045166
SGTC_1872 amphotericin b 148 nM -0.169837974938349 0.408674913034499 no 2012 0.432568780537219 2823 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3177 9107506 49.47 µM -0.17036802160595 0.408453297012037 no 2013 0.432360359761771 2789 8897194
SGTC_401 neomycin 50 µM -0.170663941687956 0.408329583595001 no 2014 0.432244008581027 2745 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.170979892976499 0.408197505944442 no 2015 0.432119787927202 2759 688788
SGTC_2835 9006588 71.43 µM -0.171066703116797 0.408161218380745 no 2016 0.432085658484954 2952 2345538
SGTC_1318 1280-3875 124 µM -0.17212834974698 0.407717502582299 no 2017 0.431668312752807 2780 373245
SGTC_2368 9071271 200 µM -0.172688102046665 0.407483601411706 no 2018 0.431448298238162 2738 27209959
SGTC_2016 5121758 140 µM -0.17358556646209 0.407108650862905 no 2019 0.431095588049804 2679 2795203
SGTC_348 k064-0012 10.7 µM -0.174939944477755 0.406542968187458 no 2020 0.430563411530446 2678 5066323
SGTC_359 0081-0058 15.9 µM -0.175075204273228 0.406486484956743 no 2021 0.430510270731203 3102 3494159
SGTC_1459 k035-0031 35.7 µM -0.175595850079909 0.406269086286194 no 2022 0.430305731425847 2704 3877128 YMR208W ERG12
SGTC_2375 9072683 200 µM -0.176239870521593 0.406000211803262 no 2023 0.430052749418092 2718 16798029
SGTC_3087 9117406 49.47 µM -0.17731867457803 0.405549917281329 no 2024 0.429629041512632 2845 42546093
SGTC_74 000s-0487 160.283 µM -0.177907434187557 0.405304220760077 no 2025 0.429397836175416 2690 677548
SGTC_2204 7233102 200 µM -0.178603915954118 0.405013618661618 no 2026 0.429124359723646 2734 2172480
SGTC_577 r071-0003 38.6 µM -0.1787513381275 0.404952114511258 no 2027 0.429066478154186 2731 4568517 YMR134W ERG29
SGTC_2089 5281248 129.67 µM -0.18180540227959 0.403678497094906 no 2028 0.427867722387357 2735 2737878
SGTC_1558 st069300 45.6 µM -0.182089281354027 0.403560164406847 no 2029 0.427756330177096 2762 24208000
SGTC_2396 5342950 42.78 µM -0.182179395233481 0.403522603013035 no 2030 0.427720971309735 2805 1886677
SGTC_3231 9132313 49.47 µM -0.184378887099248 0.402606084459957 no 2031 0.426858115762395 2786 4905967
SGTC_1848 st056003 16.4 µM -0.185794691238522 0.402016407831627 no 2032 0.426302883914019 2720 146492
SGTC_1553 gossypol 38.6 µM -0.185964854762853 0.401945550403169 no 2033 0.426236161182104 2694 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2058 5236698 133 µM -0.186846873376882 0.401578322618519 no 2034 0.425890347194453 2765 766665
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.187794833623239 0.401183736979441 no 2035 0.425518742943398 2722 756377
SGTC_1332 1480-0653 17.5 µM -0.189015734222052 0.400675689239787 no 2036 0.425040242473684 2712 5749438
SGTC_54 0159-0055 9 µM -0.18989881028815 0.400308323497413 no 2037 0.424694212379589 2964 3319099
SGTC_2384 9036245 200 µM -0.190199162934886 0.400183394803202 no 2038 0.424576533515001 2800 6462766
SGTC_2738 aclarubicin 5.55 µM -0.1902057080741 0.400180672531347 no 2039 0.42457396918906 2821 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_652 0437-0092 114 µM -0.19052368270517 0.40004842551387 no 2040 0.424449393471129 2750 3091274
SGTC_138 0850-0259 40.9225 µM -0.191119862904359 0.399800502505687 no 2041 0.42421584306006 2806 6813004
SGTC_2030 5175110 200 µM -0.192602921871281 0.39918394417353 no 2042 0.423634978226771 2877 2831986
SGTC_1109 tnp00067 928.257 nM -0.193190629675991 0.39893968340875 no 2043 0.423404838469773 2780 676295
SGTC_3226 9131256 49.47 µM -0.193885001298325 0.398651142456276 no 2044 0.423132964041074 2741 17178073
SGTC_3305 9127027 53.8275 µM -0.19572816750952 0.397885497517647 no 2045 0.42241146816193 2794 41905295
SGTC_1901 st060216 58.6 µM -0.197224391334475 0.397264260182987 no 2046 0.421825971971856 2757 688792
SGTC_1808 st050063 61.5 µM -0.197974056783876 0.396953094355461 no 2047 0.421532680834901 2866 4011993
SGTC_2051 5263410 176 µM -0.198065044078422 0.396915332453129 no 2048 0.421497086892302 2753 227584
SGTC_484 loperamide 105 µM -0.198255074197871 0.396836468528548 no 2049 0.421422749778201 2718 3955 An opioid-receptor agonist.
SGTC_3218 9131285 49.47 µM -0.198566148241024 0.396707379575591 no 2050 0.421301068026681 2865 17156417
SGTC_698 k064-0052 127 µM -0.199645087929847 0.396259730905666 no 2051 0.420879081255811 2726 5088751
SGTC_107 0358-0022 2.6945 µM -0.200405893580845 0.395944157212926 no 2052 0.420581575288172 2825 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3341 9147222 25.867 µM -0.200763602394809 0.395795807143034 no 2053 0.420441712252413 2883 1939759
SGTC_2798 7813637 45.45 µM -0.202320400053832 0.395150343412722 no 2054 0.419833126401566 2894 956368
SGTC_925 2064-1272 59.6 µM -0.20248460847982 0.395082277709493 no 2055 0.419768944928343 2785 6815817
SGTC_3125 9127534 49.47 µM -0.202563951558602 0.395049390517078 no 2056 0.419737934155854 2725 1639235
SGTC_1503 4585-0012 61.3 µM -0.20303184850883 0.394855465472917 no 2057 0.419555069545706 2954 2922052
SGTC_2857 9024691 58.44 µM -0.203506214785692 0.394658885734121 no 2058 0.419369694310832 2879 16478292
SGTC_1474 0330-0125 5.35 µM -0.203627568446859 0.394608600480954 no 2059 0.419322273990845 2800 X1474
SGTC_3036 9090181 49.47 µM -0.203665718252562 0.394592792728643 no 2060 0.419307366763474 2745 25236586
SGTC_859 0439-0102 54.6 µM -0.203763110712845 0.394552437978995 no 2061 0.419269310697874 2773 610143
SGTC_178 4092-0806 87.505 µM -0.204258628835491 0.39434713664347 no 2062 0.41907569888942 2786 2169044
SGTC_2284 7945075 39.21 µM -0.204484625569421 0.394253512208156 no 2063 0.418987402595852 2906 1245402
SGTC_1327 1436-0082 2.18 µM -0.204526195346279 0.394236291620457 no 2064 0.418971161844151 2794 15992205
SGTC_1472 k841-0093 193 µM -0.205240047804752 0.393940605241511 no 2065 0.418692290874663 2874 X1472
SGTC_2176 5809774 33.9695 µM -0.207837974562967 0.392865029586514 no 2066 0.417677740288436 2906 2870539
SGTC_2990 9074105 71.4286 µM -0.20829863592905 0.392674394853987 no 2067 0.417497898329775 2803 6502001
SGTC_536 3852-0578 10.6 µM -0.208328073038064 0.392662213818418 no 2068 0.417486406683854 2932 2869208
SGTC_413 propylparaben 100 µM -0.208924592838834 0.392415397405694 no 2069 0.417253552738016 2761 7175 A pharmaceutical preservative.
SGTC_1105 epirubicin 18.1 µM -0.209175354356769 0.392311655072034 no 2070 0.417155675611759 2768 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1922 5578187 25 µM -0.211611002518027 0.391304404369694 no 2071 0.416205262474672 3025 1350412
SGTC_2211 7117706 200 µM -0.212041547756766 0.391126430012083 no 2072 0.416037310398719 2866 822771
SGTC_3170 9103054 49.47 µM -0.213121246225547 0.390680215715389 no 2073 0.415616196609304 2842 16432970
SGTC_896 0964-0007 44.5 µM -0.213227378939564 0.390636361289533 no 2074 0.415574806988152 2729 6756758
SGTC_555 4296-0685 37 µM -0.213837451199303 0.39038430419571 no 2075 0.415336909272628 2791 2908540 YHR072W ERG7
SGTC_104 0074-0074 590.992 µM -0.215077924673387 0.389871933073173 no 2076 0.414853282356353 2741 3943124
SGTC_985 1493-0307 8.71 µM -0.215295631729186 0.389782030013473 no 2077 0.41476841757616 2913 3278274
SGTC_3011 9081274 71.4286 µM -0.215568990950622 0.389669153504845 no 2078 0.414661864558135 2809 6625322
SGTC_660 4031-1742 102 µM -0.215588873697524 0.389660943809812 no 2079 0.414654114683287 2769 6738706
SGTC_2752 diclazuril 33.15 µM -0.216488485397177 0.389289540777256 no 2080 0.414303499841364 2952 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2891 9063876 19.48 µM -0.216850749728964 0.389140009153706 no 2081 0.414162330137006 2890 6472478
SGTC_1996 st072960 66.8 µM -0.217148056039003 0.389017302476926 no 2082 0.414046482014197 2803 1719405
SGTC_427 1354-0053 47.3 µM -0.217773862899122 0.388759050568293 no 2083 0.413802655098876 3030 6813657
SGTC_114 0364-0001 490.298 µM -0.218763388121276 0.388350803236887 no 2084 0.413417184051533 2850 4003655
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.21888654791616 0.388299999956351 no 2085 0.413369212798301 2801 97141
SGTC_2421 5690543 90.72 µM -0.219158397788087 0.388187868947729 no 2086 0.413263330719097 2879 3397993
SGTC_191 3914-0123 66.505 µM -0.221894802046087 0.387059693838458 no 2087 0.412197888520113 2791 3144412
SGTC_935 2996-0153 430 µM -0.223432838826681 0.386426004125007 no 2088 0.411599324283256 2974 23738523
SGTC_3351 9150312 21.596 µM -0.223545608622982 0.386379553501718 no 2089 0.411555445263776 2802 4904905
SGTC_2020 4017018 200 µM -0.22355626592991 0.386375163770863 no 2090 0.411551298535279 2904 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1907 st060210 83.7 µM -0.224197785214032 0.386110949616641 no 2091 0.411301703378143 2984 688793
SGTC_232 clozapine 119 µM -0.22461909019749 0.385937460967205 no 2092 0.411137806263046 2783 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2860 9025725 38.96 µM -0.224856226175032 0.385839821071393 no 2093 0.411045561853627 2785 40546248
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.225395226727992 0.385617916419646 no 2094 0.410835912318601 3155 5282309
SGTC_3229 9132204 49.47 µM -0.227386069676048 0.384798618299509 no 2095 0.410061775700386 2796 17682924
SGTC_483 fpl-64176 144 µM -0.227764060050611 0.384643120649169 no 2096 0.409914834135899 2813 3423
SGTC_1714 st033236 13.627 µM -0.22861143643924 0.384294594481323 no 2097 0.409585467479057 2966 2916566
SGTC_1432 4049-0298 68.4 µM -0.229089020919856 0.384098205029775 no 2098 0.409399863304703 2914 741646
SGTC_2405 ticlatone 3.52 µM -0.229249578006612 0.38403218837949 no 2099 0.409337470388788 2706 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1756 st041558 35.5 µM -0.229718374975936 0.383839451243662 no 2100 0.409155307772565 2996 3955792
SGTC_1825 st052143 62.6 µM -0.230490113407624 0.38352222797021 no 2101 0.408855472529129 2985 674173
SGTC_1534 6-azauridine 81.6 µM -0.231120132991686 0.383263316127981 no 2102 0.408610737318436 2791 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1166 k206-0078 225 µM -0.232785499193127 0.382579171205663 no 2103 0.407963986800404 2811 5404595
SGTC_1057 3448-5381 134 µM -0.233249417970795 0.38238865503226 no 2104 0.407783866965457 2951 5497911
SGTC_1626 st003712 1.76 µM -0.233539867888347 0.382269391297159 no 2105 0.407671107593739 2986 24207035
SGTC_1387 3342-1166 1.8 µM -0.233951358455607 0.382100445309772 no 2106 0.407511370539664 2891 3418228
SGTC_2420 aureobasidin a 50 nM -0.236516222349195 0.381047894414778 no 2107 0.40651606035391 3109 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_637 1181-0519 7.26 µM -0.236672645049145 0.380983731138244 no 2108 0.406455379091374 2826 6252091 YGR060W ERG25
SGTC_2303 7774051 200 µM -0.237778623129996 0.380530161685285 no 2109 0.406026399741855 3014 2953184
SGTC_3339 9145883 14.936 µM -0.237950222395883 0.380459802307164 no 2110 0.405959851066987 2972 2030670
SGTC_2511 berberine 10.47 µM -0.238450184751572 0.380254829574463 no 2111 0.4057659739394 2843 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2107 5363541 170.161 µM -0.238621217239044 0.380184718017999 no 2112 0.405699655674431 2868 244052
SGTC_3137 9097352 49.47 µM -0.239160423625263 0.379963706265462 no 2113 0.405490594805862 3135 44120435
SGTC_2654 protoveratrine a 100 µM -0.240744253468249 0.379314747594817 no 2114 0.404876669081858 2835 5702278 A heart drug and vasodilator.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.241778428217298 0.378891187998535 no 2115 0.404475927433488 2818 364106
SGTC_1709 st033179 39.1045 µM -0.243109516434935 0.378346237723264 no 2116 0.403960279644537 2833 573381
SGTC_2192 5915882 198.485 µM -0.243357688893395 0.378244662124965 no 2117 0.403864159004156 2822 2876149
SGTC_1362 1611-0397 101 µM -0.245225347580834 0.3774805102621 no 2118 0.403140975467833 2852 27816
SGTC_346 4513-0042 7.16 µM -0.245929424548977 0.377192561688871 no 2119 0.40286843284906 2840 2827372
SGTC_341 1486-1430 230 µM -0.246605225893928 0.376916241296173 no 2120 0.402606879881547 2814 2054753 YPL210C SRP72
SGTC_1266 0828-0227 32.9 µM -0.247895070800479 0.376389026976224 no 2121 0.402107796915561 2963 3913820
SGTC_1304 1165-0502 251 µM -0.247947933858643 0.376367424513322 no 2122 0.402087345876469 2871 767425
SGTC_2830 7992007 71.43 µM -0.249200154980434 0.375855818338628 no 2123 0.401602979775071 2726 1952075
SGTC_2319 6033012 152.6 µM -0.251819966572695 0.374786177365372 no 2124 0.400590111727898 2857 847246
SGTC_2130 NSC 7 2.4545 µM -0.252865920854623 0.374359393852364 no 2125 0.400185912506117 2983 21448
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.253159371078497 0.374239684199659 no 2126 0.400072530603025 2832 6708784 An antioxidant flavonoid
SGTC_1076 itraconazole 331 nM -0.253170924883238 0.374234971205554 no 2127 0.400068066671131 2833 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_527 4476-4215 268 µM -0.253239886311494 0.374206841053138 no 2128 0.400041422982041 2867 4418754
SGTC_2597 laccaic acid a 100 µM -0.253849646823854 0.373958141949126 no 2129 0.39980585836566 2993 5491415 A textile dye.
SGTC_418 lividomycin a 100 µM -0.254111398483175 0.373851399067697 no 2130 0.399704748813865 2962 72394 An antibiotic.
SGTC_2087 5276107 200 µM -0.254478905295595 0.373701545338918 no 2131 0.399562799463689 2826 144405
SGTC_517 1365-0151 113 µM -0.254509464781248 0.373689085333123 no 2132 0.399550996472911 3027 768657
SGTC_480 am 92016 50 µM -0.255185316380595 0.373413554422439 no 2133 0.399289985779578 2915 2129 K+ channel blocker.
SGTC_988 1497-1057 103 µM -0.255858528498511 0.373139163899205 no 2134 0.399030039189966 2868 3533044
SGTC_1986 st071812 45 µM -0.257954584612251 0.372285257376274 no 2135 0.398220978750342 2881 11838594
SGTC_1743 st037606 46.3785 µM -0.258739711276866 0.371965568118682 no 2136 0.39791803871603 2877 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_920 mycophenolic acid 780.421 nM -0.259717828515586 0.371567420088203 no 2137 0.397540719637783 2900 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2712 st079126 47.7 µM -0.259816665531447 0.371527195568579 no 2138 0.397502597538634 2842 3152970
SGTC_26 0302-0163 425.158 µM -0.260127474969418 0.371400712019309 no 2139 0.39738272263742 2869 3100915
SGTC_2839 9003951 25.97 µM -0.26021588686785 0.371364735433361 no 2140 0.397348625161114 2933 2990634
SGTC_2816 7982706 58.44 µM -0.261927031799369 0.370668657737192 no 2141 0.396688849298189 2994 2981853
SGTC_2181 6316240 54.2555 µM -0.262436572193335 0.370461463142311 no 2142 0.396492439960472 2956 12779990
SGTC_123 0083-0120 66.675 µM -0.262601027300222 0.370394598719848 no 2143 0.396429054086276 2875 16001701
SGTC_1037 k284-1091 78.7 µM -0.262642872357517 0.370377585913827 no 2144 0.396412926197312 2841 3334711
SGTC_428 3448-4153 16.5 µM -0.263293314095535 0.370113170594965 no 2145 0.39616225626316 2810 3834874
SGTC_2675 theaflavin digallate 100 µM -0.263774860983639 0.369917453356667 no 2146 0.395976703374424 2886 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_165 k038-0023 64.381 µM -0.264218556361095 0.369737150093076 no 2147 0.395805756545151 2886 46368543
SGTC_2994 9053520 71.4286 µM -0.264950484101957 0.369439781238272 no 2148 0.395523803441984 3011 4647384
SGTC_485 niflumic acid 177 µM -0.26528792883984 0.369302709902216 no 2149 0.395393831431557 2984 4488 A COX2 inhibitor.
SGTC_2646 retinol 96.75 µM -0.265906806234252 0.36905136273816 no 2150 0.395155491567857 2948 445354 A vitamin A analog and teratogen.
SGTC_1252 0493-0875 34.8 µM -0.266239681661547 0.368916193849477 no 2151 0.39502731198077 2848 3960963
SGTC_1674 st016616 23.6 µM -0.267538363059837 0.368389000595797 no 2152 0.394527340406133 2824 625830
SGTC_1075 aripiprazole 15.2 µM -0.267580894070814 0.368371739526647 no 2153 0.39451096957979 2870 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1686 st019653 115.5 µM -0.2680893279054 0.368165413927285 no 2154 0.394315280177192 3016 97252
SGTC_2160 5660466 132.927 µM -0.26817161162598 0.368132026256692 no 2155 0.394283612776754 2881 2859134
SGTC_2206 7254556 146.969 µM -0.268307511984551 0.368076885131479 no 2156 0.394231312210687 2917 4398905
SGTC_370 0180-0345 38.7 µM -0.268610742254545 0.367953860242472 no 2157 0.394114622449923 2805 3989527
SGTC_3124 9127567 49.47 µM -0.272838103083716 0.366240174742931 no 2158 0.392488834157586 3109 17592030
SGTC_57 miconazole 162.5 nM -0.273018497154783 0.366167105714413 no 2159 0.392419498433071 2828 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_233 rapamycin 362 pM -0.273061196374388 0.366149811008624 no 2160 0.39240308718871 2914 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_211 3455-0679 143.504 µM -0.27367904452955 0.365899590934298 no 2161 0.392165641584023 2963 748649
SGTC_1822 st052468 42 µM -0.274007233781385 0.365766701950156 no 2162 0.392039531291758 2939 2873678
SGTC_3094 9117742 49.47 µM -0.274860214065502 0.365421392195822 no 2163 0.391711817402788 2856 17149698
SGTC_631 k072-0230 41.5 µM -0.276481821337983 0.364765222148381 no 2164 0.391089010084546 3001 5773147
SGTC_1540 guanosine 70.6 µM -0.276636372323515 0.364702704999314 no 2165 0.391029666557905 2862 6802 Guanosine is a purine nucleoside
SGTC_1127 asiatic acid 681.4 nM -0.277099229805 0.364515496855518 no 2166 0.390851956601967 2872 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_100 0086-0128 49.5915 µM -0.277113295625479 0.364509808274875 no 2167 0.390846556513688 2924 93297
SGTC_2047 4141938 200 µM -0.277672689555786 0.364283599141191 no 2168 0.390631813516985 2922 3807862
SGTC_1448 4255-0083 152 µM -0.280066188683263 0.363316244566562 no 2169 0.389713362284129 3051 5399660
SGTC_3043 9092303 49.47 µM -0.28061830040095 0.363093226981594 no 2170 0.389501589065011 2933 25236084
SGTC_1466 k213-0079 57.5 µM -0.280801073380075 0.363019408688191 no 2171 0.389431490148832 2891 3657981
SGTC_1524 corynanthine 62.1 µM -0.280974748658589 0.362949269486343 no 2172 0.389364883806942 3078 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2740 felodipine 17.08 µM -0.281014734016811 0.362933121948913 no 2173 0.38934954945116 3001 3333 L-type calcium channel blocker
SGTC_2807 7945238 51.95 µM -0.282219098462612 0.362446870248795 no 2174 0.388887757418809 3002 17148797
SGTC_1384 3089-0840 101 µM -0.283027531967383 0.362120596599255 no 2175 0.388577866022057 3028 1069836
SGTC_2966 9084041 48.03 µM -0.283131952140987 0.362078461222471 no 2176 0.388537844502966 2829 17741380
SGTC_1670 st016595 4.04 µM -0.283450015008921 0.361950127561579 no 2177 0.388415946624387 2959 597879
SGTC_3217 9129673 49.47 µM -0.283668482652258 0.361861988090667 no 2178 0.388332225070383 3093 17248312
SGTC_1345 1488-0192 31.4 µM -0.283680309441744 0.361857216851824 no 2179 0.388327692935346 3059 658348
SGTC_283 0987-0079 11.7 µM -0.284721922665634 0.361437086900897 no 2180 0.387928596829297 3000 411556
SGTC_3259 9138485 49.47 µM -0.285013423035842 0.361319541444222 no 2181 0.387816929079384 3210 17646153
SGTC_3077 9117319 49.47 µM -0.285169024293821 0.36125680169878 no 2182 0.387757325259778 2885 17154678
SGTC_167 3672-0051 66.205 µM -0.285366584173433 0.361177149258322 no 2183 0.387681652796616 2854 3237971
SGTC_117 lucigenin 22.078 µM -0.285957041626825 0.360939123766838 no 2184 0.387455512022655 2976 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_983 1491-0821 12.2 µM -0.28656219474424 0.36069523002411 no 2185 0.387223782537072 3047 46495113
SGTC_1022 4477-0945 21.3 µM -0.28810057140465 0.360075476175919 no 2186 0.386634877621299 2909 4648966
SGTC_1404 3909-7820 48.3 µM -0.288295563889558 0.359996947285917 no 2187 0.386560251289274 3011 23741373
SGTC_2323 6148992 148.28 µM -0.288598628895325 0.359874906318767 no 2188 0.386444272430498 2950 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1600 coumarin 106 71.1 µM -0.288957895714975 0.359730251998911 no 2189 0.386306799041732 3083 100336 A hepatotoxic, DNA x-linker.
SGTC_177 1327-0068 8.361 µM -0.289196322695127 0.359634263428885 no 2190 0.38621557287447 2980 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2476 5806916 10.51 µM -0.289219424942826 0.359624963141013 no 2191 0.386206733900657 2898 2870194
SGTC_1795 st049545 62.3 µM -0.290290381984401 0.359193918561901 no 2192 0.385797048139331 3030 5291882
SGTC_392 N-ethylmaleimide 8.33 µM -0.290475791872299 0.359119311967302 no 2193 0.385726134039617 2954 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_784 4579-0127 173 µM -0.292608886683008 0.358261368682114 no 2194 0.384910560176099 3112 1948547
SGTC_797 k781-0471 270 µM -0.293603098330624 0.357861734962427 no 2195 0.384530603978392 2944 23738129
SGTC_970 1315-0089 19.5 µM -0.294412231671688 0.357536610316456 no 2196 0.384221460681344 2931 6811083 YLR033W RSC58
SGTC_966 1300-0360 30.2 µM -0.294739638232825 0.357405081704117 no 2197 0.384096390294091 2920 70588
SGTC_2828 7998861 71.43 µM -0.295133180950432 0.357247006715525 no 2198 0.38394607164952 3040 2988188
SGTC_309 k408-0051 1.48 µM -0.295447563590265 0.357120745692232 no 2199 0.383826001745909 2961 3640463
SGTC_2962 9082311 13.18 µM -0.296093644888121 0.356861318385671 no 2200 0.383579283576731 2893 16459453
SGTC_3291 9121177 71.43 µM -0.296788250680262 0.356582480394279 no 2201 0.383314088071442 2971 17015612
SGTC_3281 9140613 49.47 µM -0.296877642837741 0.356546600955908 no 2202 0.383279962755162 2966 16013766
SGTC_290 2043-6722 48.1 µM -0.299198688154122 0.355615445428006 no 2203 0.382394225089088 3021 773758 YLR208W SEC13
SGTC_994 3910-0338 138 µM -0.300171246487865 0.35522553071845 no 2204 0.382023268165076 3123 3479481
SGTC_709 3807-1509 243 µM -0.301518911703672 0.354685479980348 no 2205 0.381509415581693 2940 1886677 YPL242C IQG1
SGTC_2449 5812982 45.77 µM -0.302192079844803 0.354415830144491 no 2206 0.381252820774208 3019 776185
SGTC_2138 5575593 77.673 µM -0.303101090669075 0.354051824994638 no 2207 0.380906411496437 2953 762213
SGTC_1852 st056254 31.4 µM -0.30335519167033 0.353950096382081 no 2208 0.38080959478267 2923 442583
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.303965716827775 0.353705717000655 no 2209 0.380577005045334 3010 77254
SGTC_1683 st010134 710 nM -0.304930572480771 0.353319630083934 no 2210 0.380209515230705 2925 3818134
SGTC_858 0438-0351 2.77 µM -0.306009537287783 0.352888061131234 no 2211 0.379798692095453 2973 2799119
SGTC_3107 9121808 49.47 µM -0.30627096254045 0.352783523596492 no 2212 0.379699173059708 2910 662681
SGTC_2753 fluvastatin 17.09 µM -0.306326113705197 0.352761471420284 no 2213 0.379678179201376 3036 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2923 7992654 58.14 µM -0.307277918655099 0.3523809705011 no 2214 0.379315920781836 2982 2985126
SGTC_2585 alliin 100 µM -0.308390140193588 0.351936527345222 no 2215 0.37889274180378 3135 87310 A garlic compound which reacts with lipids.
SGTC_916 4466-0038 42 nM -0.309048183758131 0.351673668647439 no 2216 0.3786424371411 3153 5722064 YGL116W CDC20
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.309608642199446 0.351449846700392 no 2217 0.378429291751007 3052 616764
SGTC_3021 9087658 49.47 µM -0.310343243022126 0.351156558095931 no 2218 0.378149975080683 3050 25237042
SGTC_1722 st034304 3.6505 µM -0.310935904329647 0.35092000327971 no 2219 0.377924674355508 2965 4036148 YLR033W RSC58
SGTC_1705 st027868 56.3335 µM -0.311328978165297 0.350763143658331 no 2220 0.377775269879195 3027 292948
SGTC_2914 7968218 45.32 µM -0.312716136034949 0.350209789357043 no 2221 0.377248167608824 3051 2977111
SGTC_286 k060-0067 22.9 µM -0.314044128760155 0.349680334516076 no 2222 0.376743761508189 2982 5985051
SGTC_2249 haloperidol 116.36 µM -0.314973215823516 0.349310092271664 no 2223 0.376390995125079 2931 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2179 6298986 200 µM -0.315455945872953 0.349117780366991 no 2224 0.37620774739831 3108 738374
SGTC_1697 st025554 27.742 µM -0.315488052241451 0.349104991078516 no 2225 0.376195560583894 2937 1269519
SGTC_22 0964-0034 14.468 µM -0.316814822914269 0.348576633718971 no 2226 0.375692058053289 3006 138402
SGTC_1104 tacrolimus 29.8 µM -0.317240031967961 0.348407365603745 no 2227 0.375530738176834 3005 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_666 0272-0154 136 µM -0.317817394393268 0.348177576276961 no 2228 0.375311727736399 3008 6870312
SGTC_2286 7945697 125 µM -0.318198402177059 0.348025966300975 no 2229 0.375167222354117 3023 1245733
SGTC_2187 6125751 200 µM -0.318239255571223 0.348009711428568 no 2230 0.375151728866815 2999 874498
SGTC_837 0091-0265 12.5 µM -0.320016575686457 0.347302816641424 no 2231 0.374477882602184 2965 759367
SGTC_2508 celastrol 40.54 µM -0.320947888084844 0.346932616894328 no 2232 0.37412494129436 2997 122724 Celastrol is a natural product and antioxidant.
SGTC_106 0092-0003 11.579 µM -0.321743887463246 0.346616320269144 no 2233 0.373823363424313 3022 1072148
SGTC_530 4358-1714 28 µM -0.321906875494565 0.346551568868334 no 2234 0.373761622162997 3052 1564641
SGTC_2616 abietic acid 100 µM -0.322498847155358 0.346316429849449 no 2235 0.373537405489832 3132 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2345 9052315 157.45 µM -0.323584785111187 0.345885234866028 no 2236 0.373126204227812 3061 6469265
SGTC_3200 9114385 49.47 µM -0.325283676755955 0.345211054404548 no 2237 0.372483191886205 3109 17018030 YLR208W SEC13
SGTC_1641 st009299 47.1 µM -0.32661308592423 0.34468383994005 no 2238 0.371980272387243 3036 4046054
SGTC_1990 st072050 59.8 µM -0.326713620187942 0.344643982510295 no 2239 0.371942248841405 2960 17233948
SGTC_2925 9010536 32.5 µM -0.326977026776429 0.344539561520865 no 2240 0.371842630496472 3032 2994177
SGTC_2077 5212015 200 µM -0.328943263459938 0.343760470611262 no 2241 0.371099286384227 2929 780900
SGTC_256 clotrimazole 625 nM -0.329025583398035 0.343727867046369 no 2242 0.371068175447187 3056 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2708 st078559 56 µM -0.331152114245334 0.34288603847572 no 2243 0.370264794348039 3085 17250902
SGTC_1757 st041620 31.8375 µM -0.331196703575401 0.342868395251413 no 2244 0.370247955008026 3046 5289815
SGTC_1453 4237-0541 195 µM -0.331251099201655 0.342846872309834 no 2245 0.370227412617511 3125 739892
SGTC_2344 7990960 76.95 µM -0.332383304209338 0.34239900396868 no 2246 0.369799921959236 3007 140813
SGTC_3277 9138724 49.47 µM -0.332575848603771 0.342322860864803 no 2247 0.369727238278984 3030 15943418
SGTC_1170 0310-0127 64.8 µM -0.333291699390099 0.342039828610954 no 2248 0.369457052242664 3053 774975
SGTC_902 1120-0002 2.07 µM -0.335807239451288 0.341045941973307 no 2249 0.368508115296089 2990 3280475
SGTC_2700 st077718 96.8 µM -0.335968538350789 0.340982250509225 no 2250 0.368447295806425 3055 904970
SGTC_1431 4049-0260 9.09 µM -0.336207714954765 0.340887816123227 no 2251 0.368357117755637 2974 3854841
SGTC_1277 0873-0036 22 µM -0.336710978244534 0.340689144635946 no 2252 0.368167393357397 3081 5965735
SGTC_2292 7671323 168.05 µM -0.338508219862971 0.339980014837982 no 2253 0.367490116889813 3163 937504
SGTC_777 1315-0167 517 µM -0.338793363330903 0.339867558961114 no 2254 0.367382700611868 3079 4221767
SGTC_3113 9123498 49.47 µM -0.338797399125955 0.339865967412405 no 2255 0.367381180363634 3051 8897275
SGTC_2876 9059903 25.97 µM -0.338984600117475 0.339792146311233 no 2256 0.367310665693774 2983 6916095
SGTC_3240 9133527 49.47 µM -0.340126625347031 0.339341931640977 no 2257 0.366880585841654 3014 17617455
SGTC_1664 st014217 9.02 µM -0.34047917514991 0.339202994040739 no 2258 0.366747851416673 3069 3982782
SGTC_1940 st075990 51.1 µM -0.340486075821884 0.339200274748566 no 2259 0.366745253483872 3265 1084979
SGTC_1677 st019204 53.9 µM -0.340862736088388 0.339051859982508 no 2260 0.366603459445963 3097 3945625
SGTC_489 paxilline 115 µM -0.341158346384556 0.338935398680222 no 2261 0.366492189478378 3066 105008 A toxic potassium channel blocker.
SGTC_724 3910-0327 137 µM -0.341530500193483 0.338788803491812 no 2262 0.366352123905911 3079 2885483
SGTC_2641 levomentholum 100 µM -0.342127658604589 0.338553627717844 no 2263 0.366127411740739 3061 16666
SGTC_2272 7805186 180 µM -0.343593195879787 0.337976729786599 no 2264 0.365576121211489 3145 2956062 YPR165W RHO1
SGTC_3090 9117696 49.47 µM -0.343873777760513 0.337866324136665 no 2265 0.365470606467017 3048 7923821
SGTC_1772 st048439 82.2 µM -0.344093765078336 0.337779771484304 no 2266 0.365387885843703 3101 2927068 YDL195W SEC31
SGTC_1786 berberine 21.6 µM -0.344188709608066 0.337742418794797 no 2267 0.365352186307602 3006 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_706 4262-0057 46.9 µM -0.346293079232056 0.336914937110294 no 2268 0.364561234609219 3018 883298
SGTC_1398 3558-0053 112 µM -0.346490930494708 0.336837178400697 no 2269 0.364486899505116 2946 4532369
SGTC_3278 9139605 49.47 µM -0.347235510209202 0.336544609195749 no 2270 0.364207197626359 3185 7958859
SGTC_398 bronopol 33.3 µM -0.348765369961778 0.335943788916488 no 2271 0.363632731821965 2985 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_762 1165-0429 115 µM -0.349746519040067 0.335558683637389 no 2272 0.363264469326108 3141 5967793
SGTC_1471 k673-0312 37 µM -0.350079906977289 0.335427866707671 no 2273 0.363139364921822 3063 24099884
SGTC_363 0455-0021 3.06 µM -0.350115995690053 0.335413707179943 no 2274 0.36312582344504 3000 4597466
SGTC_1821 st053465 65.6 µM -0.351082748890665 0.335034485381518 no 2275 0.362763134809124 3097 675086
SGTC_119 0121-0043 24.815 µM -0.352142571792643 0.334618948919805 no 2276 0.362365671433177 3048 1092378
SGTC_1024 4507-0395 26 µM -0.356975000053047 0.332726818332215 no 2277 0.36055526071344 3198 4201836
SGTC_3064 1327-0027 10 µM -0.357058460613062 0.332694176689872 no 2278 0.360524020530565 2994 16000455 YPR107C YTH1
SGTC_1912 st060209 90.8 µM -0.359155985039323 0.331874246449221 no 2279 0.359739200838976 3091 688787
SGTC_1754 st042065 16.137 µM -0.3597126015532 0.331656797867458 no 2280 0.359531033667107 3107 1126236 YIL048W NEO1
SGTC_2215 7188065 200 µM -0.361422214114075 0.330989273115661 no 2281 0.358891922132762 3157 940217
SGTC_1 0258-0098 57.368 µM -0.363068547577148 0.330346963306564 no 2282 0.358276839598172 3086 6790032 YDR047W HEM12
SGTC_3302 9125395 16.351 µM -0.364729103469655 0.329699610635685 no 2283 0.35765681578242 3074 17599668
SGTC_1285 0929-0069 65.5 µM -0.364761180799197 0.329687110593048 no 2284 0.357644842334879 3080 1206237
SGTC_1123 mangostin 811.285 nM -0.365096804922933 0.329556334437955 no 2285 0.357519572920594 3097 5281650 An antioxidant.
SGTC_575 k072-0246 11.9 µM -0.365871169416378 0.329254682352218 no 2286 0.357230605237916 3078 6796779
SGTC_3251 9135047 49.47 µM -0.368719419246602 0.328146109767346 no 2287 0.356168436317712 3131 17682963
SGTC_137 0438-0332 85.389 µM -0.369504970615911 0.327840629449479 no 2288 0.355875684447502 3166 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2281 7943571 200 µM -0.369729481784917 0.327753344097344 no 2289 0.355792031348453 3285 1244024
SGTC_2195 6536160 144.242 µM -0.370108604486406 0.327605970307036 no 2290 0.355650785593562 3030 3834386
SGTC_321 4534-3890 65.3 µM -0.370349561043 0.327512318858907 no 2291 0.355561025244375 3157 699746
SGTC_3075 9116269 49.47 µM -0.370384054839701 0.327498913205523 no 2292 0.355548176383203 3238 17015205 YNL244C SUI1
SGTC_433 pimozide 108 µM -0.370658298758484 0.327392339089036 no 2293 0.355446026986242 3005 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1333 1482-0047 286 µM -0.370783262925624 0.327343781343363 no 2294 0.355399484222009 3189 3811116
SGTC_3327 9140648 26.9345 µM -0.372378178467186 0.326724296477076 no 2295 0.35480564932993 3185 8029710
SGTC_1312 1218-2183 165 µM -0.373039929065162 0.326467404410107 no 2296 0.354559363154038 3112 6744073
SGTC_460 trequinsin 123 µM -0.376375599322905 0.325173749523649 no 2297 0.353318841785172 3146 5537 A vasodilator.
SGTC_1002 4049-0206 172 µM -0.376443041620962 0.325147615396485 no 2298 0.353293776298497 3051 4662749
SGTC_2261 9010538 184.68 µM -0.377894606579876 0.324585337539703 no 2299 0.35275444460634 3157 6457250
SGTC_1742 st038235 28.8875 µM -0.37913988507912 0.324103285113856 no 2300 0.352291994701698 3175 564103 YBR002C RER2
SGTC_2505 galangin 7.89 µM -0.379428024421033 0.323991787153048 no 2301 0.35218502159176 2998 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2953 9074162 66.49 µM -0.379562602322271 0.323939716501898 no 2302 0.352135062907829 3186 16451992
SGTC_2607 solasodine 47.35 µM -0.381410301364187 0.323225156659386 no 2303 0.351449409161079 3091 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_328 k915-0120 63.5 µM -0.38729925924748 0.320952081352334 no 2304 0.349267336932487 3187 6624543
SGTC_1118 chelidonine 707.474 nM -0.388122571438869 0.320634823050377 no 2305 0.348962664554722 3197 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1804 st050076 49.1 µM -0.388245428832278 0.320587491933405 no 2306 0.348917208667828 3184 3895976
SGTC_176 1486-1328 72.834 µM -0.389614401162828 0.320060289432344 no 2307 0.348410850745918 3137 22310231
SGTC_2707 st078556 66.6 µM -0.390351138973433 0.319776715870553 no 2308 0.348138456556276 3144 17250899
SGTC_2768 sulfasalazine 50.2 µM -0.390626858929163 0.319670617140886 no 2309 0.34803653470737 3239 5384001 An antioxidant and salicylic acid derivative.
SGTC_2298 7976326 193.81 µM -0.391059188505949 0.319504283779229 no 2310 0.34787674309683 3082 2235818
SGTC_1373 2887-0003 58.5 µM -0.391228354490563 0.319439209177524 no 2311 0.347814225683501 3138 776948
SGTC_329 k048-0121 21.3 µM -0.391294293855635 0.319413845194592 no 2312 0.34778985808393 3166 6832902
SGTC_2993 9054257 71.4286 µM -0.39377225096273 0.318461297105785 no 2313 0.34687459658287 3075 6470217 YGL055W OLE1
SGTC_965 1291-5240 308 µM -0.394729709666851 0.318093562446299 no 2314 0.346521187200619 3228 2834598
SGTC_407 eburnamonine 100 µM -0.395108847563282 0.317947995093946 no 2315 0.346381279793629 3056 3195
SGTC_1224 0823-0416 294 µM -0.396144846823556 0.317550373875507 no 2316 0.345999087894288 3234 3598164
SGTC_3213 9129884 49.47 µM -0.397102098071471 0.317183163488988 no 2317 0.345646086417954 3161 17190742
SGTC_2311 7694451 200 µM -0.397719602738675 0.31694637845925 no 2318 0.345418443013716 3140 2163142
SGTC_741 4582-0002 126 µM -0.399238193740959 0.316364386650584 no 2319 0.344858851609802 3074 2912688
SGTC_3196 9111891 49.47 µM -0.402045737970182 0.315289608156951 no 2320 0.343825182866817 3134 18891510
SGTC_2754 granisetron 64.02 µM -0.402068752671455 0.315280804154784 no 2321 0.34381671422918 3242 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3274 9138298 49.47 µM -0.403452165691419 0.314751788650646 no 2322 0.343307808732855 3070 17015756
SGTC_3114 9122766 49.47 µM -0.404702042846393 0.314274163753112 no 2323 0.342848270194405 3169 17176985
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.405076972386292 0.314130949689823 no 2324 0.342710466272376 3215 140250 A respiratory chain inhibitor.
SGTC_444 curcumin 90.4 µM -0.405583561900297 0.313937489134474 no 2325 0.342524304473183 3235 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_97 0535-0701 19.132 µM -0.405849219824572 0.313836057942908 no 2326 0.3424266956343 3130 2832013 YGL099W LSG1
SGTC_2659 sanguinarine 24.21 µM -0.407396349895306 0.313245625946273 no 2327 0.341858453701909 3093 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_219 mitoxanthrone 164.414 µM -0.407489528712386 0.313210081329063 no 2328 0.341824241683309 3142 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3057 9095946 49.47 µM -0.408289483564078 0.312904996610633 no 2329 0.341530579576257 3119 24540043
SGTC_539 4859-0462 2.54 µM -0.409658626316249 0.312383133769205 no 2330 0.341028192139907 3262 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_64 000l-0018 272.079 µM -0.410235193063099 0.312163481896744 no 2331 0.340816713429514 3059 6811119
SGTC_1046 2001-0062 216 µM -0.410910092161997 0.311906453622455 no 2332 0.340569230972147 3095 739778
SGTC_389 tpck 16.7 µM -0.411418669879256 0.311712827601574 no 2333 0.340382783150389 3186 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1278 0874-0585 172 µM -0.412397497520124 0.311340314240926 no 2334 0.340024048539508 3189 766306
SGTC_510 ag-490 170 µM -0.412478985797735 0.311309310871891 no 2335 0.339994190086223 3236 5328779
SGTC_522 1273-0010 11.6 µM -0.413699122616979 0.310845252690506 no 2336 0.339547234866342 3324 5705015
SGTC_365 0121-0052 13.6 µM -0.415557765484504 0.310138927687073 no 2337 0.338866818554886 3244 3101739
SGTC_730 1436-0052 41.2 µM -0.415760511905679 0.310061921899699 no 2338 0.338792628415646 3181 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_844 0330-0132 15.3 µM -0.41664310490758 0.309726798431969 no 2339 0.338469737793371 3253 2828079
SGTC_2595 hexamethylquercetagetin 100 µM -0.417525593731232 0.309391872574043 no 2340 0.338147003976506 3170 386331
SGTC_1947 st076332 61.6 µM -0.417746365668658 0.309308109023964 no 2341 0.33806628434825 3259 24208416
SGTC_962 1254-0300 21.5 µM -0.419206916776987 0.308754208009815 no 2342 0.33753245876697 3112 7340576
SGTC_3338 9144300 39.5675 µM -0.420532781325701 0.308251762077126 no 2343 0.337048143498098 3179 4901274
SGTC_2502 avocadyne acetate 18.59 µM -0.421061742944006 0.308051408397497 no 2344 0.336854998312453 3068 3952079
SGTC_2843 9000894 45.46 µM -0.42264361988805 0.307452585631022 no 2345 0.336277648179358 3188 2242070
SGTC_1207 2099-0101 141 µM -0.42304107415809 0.307302209051509 no 2346 0.336132646761642 3238 5837381
SGTC_2214 7179297 48.276 µM -0.423368591709517 0.307178317328491 no 2347 0.336013178356583 3173 769744
SGTC_2996 9066192 71.4286 µM -0.424109524429909 0.306898122176841 no 2348 0.335742969857764 3179 6472854
SGTC_1915 st067105 30.6 µM -0.424129418192605 0.306890600597007 no 2349 0.335735716031762 3217 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1762 st045503 25.4615 µM -0.42430389209963 0.306824637704511 no 2350 0.33567210055532 3217 4645554
SGTC_2304 7443016 91.4 µM -0.425987556333059 0.306188420821187 no 2351 0.335058456702728 3137 939854
SGTC_2189 6047310 154.431 µM -0.426406922714776 0.30603004296761 no 2352 0.334905678933848 3136 711535
SGTC_1451 4152-0210 104 µM -0.426836838184938 0.305867718779782 no 2353 0.334749086423714 3296 659563
SGTC_1870 st057514 26.5 µM -0.427641485822543 0.305564008570794 no 2354 0.334456078615371 3118 5393161
SGTC_2762 leflunomide 42.06 µM -0.428563462834572 0.305216177386099 no 2355 0.334120469926731 3163 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_300 r073-0011 5.04 µM -0.429390286062438 0.304904394083788 no 2356 0.333819610906033 3262 2735780
SGTC_2127 5253358 187.912 µM -0.429492985951092 0.304865677295318 no 2357 0.333782248596125 3092 20612
SGTC_1676 st018489 23.4 µM -0.431184080327075 0.304228466763831 no 2358 0.333167264196362 3160 3696235
SGTC_939 1165-0479 45.3 µM -0.431585384645555 0.304077340969751 no 2359 0.333021391382217 3269 1377347
SGTC_2825 7998094 58.44 µM -0.432628534673546 0.303684661355386 no 2360 0.332642327970229 3188 2987815
SGTC_566 0958-0068 16.5 µM -0.433523842384137 0.303347815576839 no 2361 0.332317124380212 3292 6815365
SGTC_2133 5320837 200 µM -0.433591019265811 0.30332254804218 no 2362 0.332292728735783 3291 2841355
SGTC_2 0422-0095 29 µM -0.433696325795143 0.303282940529401 no 2363 0.3322544875356 3199 6790840
SGTC_3208 9114115 49.47 µM -0.435543941585084 0.302588398409699 no 2364 0.331583825494317 3226 650895
SGTC_1369 1866-0067 208 µM -0.436567031806515 0.302204112776868 no 2365 0.331212688150603 3308 3531355
SGTC_946 3434-1334 87.4 µM -0.436812233373022 0.302112044514685 no 2366 0.331123763166426 3260 4047976
SGTC_2234 tolnaftate 200 µM -0.440465707766806 0.300741732780555 no 2367 0.329799921917193 3216 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_246 cycloheximide 667 µM -0.441323808134454 0.300420291521608 no 2368 0.329489296288894 3147 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2885 9057732 51.95 µM -0.442511681965041 0.299975574671705 no 2369 0.329059489377804 3319 6471414
SGTC_2232 chlorophetanol 41.5365 µM -0.442998467766549 0.299793417630504 no 2370 0.328883421493949 3276 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2185 6113692 200 µM -0.443297282714616 0.299681624791149 no 2371 0.328775360489556 3290 874150
SGTC_2977 9011197 71.43 µM -0.443904897539674 0.299454361806135 no 2372 0.328555671763993 3343 2704722
SGTC_1358 1509-0022 2.48 µM -0.443913326621516 0.299451209670431 no 2373 0.328552624568469 3255 3258434
SGTC_2869 9037858 32.47 µM -0.444582793017136 0.299200904374302 no 2374 0.328310642348294 3152 27187042
SGTC_767 0929-0023 86 µM -0.444673121136545 0.299167139066081 no 2375 0.328277998276588 3297 1204563
SGTC_1771 st048882 4.1505 µM -0.444765271474457 0.299132694381489 no 2376 0.32824469701653 3170 4580403
SGTC_3311 9131146 2.8755 µM -0.445069609087158 0.299018949445158 no 2377 0.328134725284344 3212 4900406 YPR165W RHO1
SGTC_1851 st056236 18.9 µM -0.445667943761519 0.298795381594601 no 2378 0.327918561791032 3346 5393171
SGTC_2644 guaiazulene 100 µM -0.446199671914107 0.298596765057389 no 2379 0.32772650994937 3272 3515 A coloring agent.
SGTC_2018 5133068 143 µM -0.446825175024739 0.298363197631396 no 2380 0.327500646392901 3154 785362
SGTC_2984 9022109 38.96 µM -0.447506567444444 0.298108855410582 no 2381 0.327254673540513 3310 6459207
SGTC_1178 0988-0033 191 µM -0.449839988952807 0.297238612313412 no 2382 0.326412910661451 3291 5392207
SGTC_1684 st024538 14.6195 µM -0.450370329817928 0.297040985198999 no 2383 0.326221717530926 3200 6732859
SGTC_3028 9087778 49.47 µM -0.451145696346211 0.296752159515904 no 2384 0.325942272414212 3181 17217395
SGTC_1162 k048-0130 20.1 µM -0.451806802391776 0.296505997703878 no 2385 0.325704084406683 3190 6797406
SGTC_385 1494-0393 12.4 µM -0.452025160346639 0.296424713018824 no 2386 0.325625428466844 3211 3090647
SGTC_298 1391-0729 10 µM -0.452047858266264 0.296416264206986 no 2387 0.325617252767681 3189 3237558
SGTC_3164 9100705 49.47 µM -0.45303864417701 0.296047573108092 no 2388 0.325260457472455 3327 17174235
SGTC_1924 st058459 75.1 µM -0.454939362941092 0.295340867801347 no 2389 0.32457643160822 3290 688683
SGTC_1564 D-Arginine 115 µM -0.456245899946814 0.294855535564239 no 2390 0.324106581137633 3239 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_557 1315-0110 16.2 µM -0.456460949969769 0.294775687341606 no 2391 0.32402927271523 3186 6833801
SGTC_756 0508-1999 28.3 µM -0.457885140157596 0.294247136360293 no 2392 0.32351748166061 3196 6753853
SGTC_1001 4048-4355 44.4 µM -0.458110384586861 0.294163582885054 no 2393 0.323436569295659 3188 21824233
SGTC_957 1187-1561 14.1 µM -0.458333064036829 0.294080991655949 no 2394 0.323356586529848 3308 1538454
SGTC_1931 st074438 57.1 µM -0.459473508667644 0.293658171811748 no 2395 0.322947085751802 3268 2787313
SGTC_2154 5570129 200 µM -0.463942492440859 0.292004014261962 no 2396 0.321344473889696 3312 673366
SGTC_1163 k060-0048 49.9 µM -0.464233079701373 0.291896606156569 no 2397 0.321240381731936 3238 6809982
SGTC_1790 st045711 43.5 µM -0.46443079538638 0.291823536160914 no 2398 0.321169565413832 3383 585119
SGTC_2518 prenyletin 46.28 µM -0.46530684647746 0.291499875602974 no 2399 0.320855866283225 3285 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1486 3970-0793 4.53 µM -0.466033686327037 0.29123146887602 no 2400 0.320595694214508 3319 2844330
SGTC_3122 9126309 49.47 µM -0.467122232663416 0.290829707448044 no 2401 0.320206214267202 3324 17591206
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.467611690314728 0.290649142565071 no 2402 0.320031151695132 3252 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_216 k038-0035 28.382 µM -0.467823829739197 0.290570898910196 no 2403 0.319955288986985 3288 4444231 YPR107C YTH1
SGTC_448 monastrol 171 µM -0.469556349135163 0.289932260797239 no 2404 0.31933600862613 3275 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_778 3456-2434 196 µM -0.471311674761823 0.289285887960366 no 2405 0.318709089875463 3335 5539063
SGTC_1097 itavastatin 7.23 µM -0.472218043367781 0.288952396404446 no 2406 0.318385581024944 3258 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3250 9135583 49.47 µM -0.472703205893191 0.288773958839203 no 2407 0.318212469528156 3339 7699353
SGTC_1274 0865-0114 173 µM -0.474333695661649 0.288174662677139 no 2408 0.317630983328497 3273 870624
SGTC_2105 5350118 200 µM -0.474940896581462 0.287951632424859 no 2409 0.317414550353677 3277 2133313
SGTC_593 1203-0218 61.7 µM -0.475036425472263 0.287916551241513 no 2410 0.317380505357193 3364 3666956
SGTC_1845 st056753 3.01 µM -0.475087130192224 0.287897931709361 no 2411 0.317362435618883 3181 5375839
SGTC_156 3474-0145 5.642 µM -0.475302607792871 0.287818811452252 no 2412 0.317285650308841 3344 2265471
SGTC_960 1222-0186 7.7 µM -0.476041764588556 0.287547481844489 no 2413 0.317022312011824 3340 3126296
SGTC_2813 7971799 71.43 µM -0.476188704383564 0.287493557611222 no 2414 0.316969973024286 3313 2234054
SGTC_765 1319-0117 244 µM -0.477378301985889 0.287057173080572 no 2415 0.316546381101132 3242 3487746 YGL099W LSG1
SGTC_3033 9090887 49.47 µM -0.480978789152879 0.285738307933778 no 2416 0.315265786923015 3259 19325384
SGTC_130 0136-0219 337.655 µM -0.481283309492894 0.285626893898657 no 2417 0.315157578868621 3253 234244
SGTC_1957 st077035 62.4 µM -0.481529114561425 0.285536976941974 no 2418 0.315070246225503 3360 705593
SGTC_2178 5812956 200 µM -0.482182987224989 0.285297852046967 no 2419 0.314837980646346 3274 5403383
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.483060762692714 0.28497699471602 no 2420 0.314526296496602 3310 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2253 7938677 135.83 µM -0.485999235134455 0.283904135430027 no 2421 0.31348385411862 3381 2301972
SGTC_1242 0402-0103 60.1 µM -0.487361014415947 0.283407595526369 no 2422 0.313001258026899 3253 432868
SGTC_302 1094-0063 18.9 µM -0.487572248076132 0.283330611591284 no 2423 0.312926428352558 3235 5440289
SGTC_3159 9100096 49.47 µM -0.488155859933587 0.283117966866899 no 2424 0.312719723504163 3253 25236875
SGTC_1130 3454-2858 15.9 µM -0.488195086050558 0.283103677192199 no 2425 0.312705832428508 3276 715628 YIL048W NEO1
SGTC_378 3970-0959 8.33 µM -0.488379274314218 0.283036583913149 no 2426 0.312640609720727 3342 6615653
SGTC_974 1326-0144 138 µM -0.489463276071111 0.282641875070873 no 2427 0.312256873947336 3277 5411856
SGTC_142 0335-0849 62.6745 µM -0.492043697691921 0.281703352764481 no 2428 0.311344226327794 3407 3889043 YPR107C YTH1
SGTC_1713 st033146 12.748 µM -0.492814438951232 0.281423318993093 no 2429 0.311071853728137 3412 674619
SGTC_2981 9013952 38.96 µM -0.493200632463323 0.281283053664246 no 2430 0.310935415520959 3295 2996344
SGTC_1552 6-methylflavone 10.6 µM -0.493981845301715 0.28099942070715 no 2431 0.310659500499492 3357 689013
SGTC_3283 9109332 35.8195 µM -0.495280107744193 0.280528369768339 no 2432 0.310201205271524 3242 17027281
SGTC_3123 9126162 49.47 µM -0.49705968273264 0.279883304922135 no 2433 0.309573482307469 3248 25239884
SGTC_486 niguldipine 82 µM -0.497074614577618 0.279877895433972 no 2434 0.309568217630597 3298 1236 A calcium channel blocker.
SGTC_457 grayanotoxin iii 135 µM -0.497077652265842 0.279876794950688 no 2435 0.309567146605849 3359 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3115 9123671 49.47 µM -0.500985337567401 0.278462872645444 no 2436 0.308190721029615 3411 3286988
SGTC_2194 5927483 104.545 µM -0.504364887045875 0.277242859542916 no 2437 0.307002493902501 3299 760979
SGTC_2270 7924575 90.91 µM -0.504999834457453 0.277013936419926 no 2438 0.306779476124402 3396 1262135
SGTC_1612 st002233 45.4 µM -0.505710098058393 0.276757968586333 no 2439 0.306530089150972 3402 1035021
SGTC_3168 9103419 49.47 µM -0.506299243863283 0.276545737657298 no 2440 0.306323296874931 3332 16649256
SGTC_1401 3807-4679 7.6 µM -0.507064608892386 0.276270145604547 no 2441 0.306054743134731 3351 3291456
SGTC_2709 st078560 56 µM -0.507935186788306 0.275956832491101 no 2442 0.305749398646297 3433 17250903
SGTC_190 3970-0790 3.722 µM -0.508796091862945 0.275647172258355 no 2443 0.305447579531443 3361 2832352
SGTC_2363 9053361 176 µM -0.509953012137008 0.275231307105143 no 2444 0.305042190561529 3456 6469797 YMR079W SEC14
SGTC_1964 st076914 61 µM -0.510512114224675 0.275030443709323 no 2445 0.304846364875818 3363 24208661
SGTC_1137 ixabepilone 100 µM -0.510782404712726 0.274933364864572 no 2446 0.304751715582149 3397 154225 A novel microtubule stabilizer.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.511299825695537 0.274747572543574 no 2447 0.304570563525404 3343 16623 A steroid.
SGTC_1850 st056238 17 µM -0.511710350242065 0.274600207987119 no 2448 0.304426870614701 3380 5393177
SGTC_2172 5754775 163.918 µM -0.51185897117221 0.274546867667339 no 2449 0.304374857355646 3259 2263357
SGTC_2664 lyso-paf C-16 73.48 µM -0.512074870591355 0.274469390084295 no 2450 0.304299305515246 3296 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2802 7925815 54.55 µM -0.512508638257759 0.27431376100788 no 2451 0.304147538113054 3276 1262923
SGTC_1732 st034308 51.822 µM -0.512976292715604 0.274146022700295 no 2452 0.303983952132445 3237 830119
SGTC_748 act1.228 77.9 µM -0.5130680822459 0.274113105579635 no 2453 0.303951848672006 3351 4421505 YNR035C ARC35
SGTC_362 0310-0100 9.03 µM -0.513471829426846 0.273968338892224 no 2454 0.303810655731083 3384 790235
SGTC_2301 7769476 200 µM -0.514924777066793 0.273447686123656 no 2455 0.303302793058406 3328 977820
SGTC_1199 1638-0010 4.46 µM -0.515003445502986 0.273419509871497 no 2456 0.303275306160297 3275 3111136
SGTC_1185 1319-0113 81.3 µM -0.515888510686057 0.273102609914122 no 2457 0.30296613950775 3383 4672763
SGTC_809 3998-0021 90 µM -0.516345115402244 0.272939192583688 no 2458 0.302806695750481 3384 715485
SGTC_1179 1021-1431 9.29 µM -0.516800540956985 0.272776245585754 no 2459 0.302647701191078 3348 2840958
SGTC_2933 9026794 32.47 µM -0.517629547533059 0.272479758735491 no 2460 0.302358381049171 3291 17586027
SGTC_2266 7929956 200 µM -0.517932347199139 0.272371505033911 no 2461 0.302252736058553 3399 2967153
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.518324412069724 0.272231369937027 no 2462 0.302115971586328 3268 688667
SGTC_775 4577-0580 57.3 µM -0.518688901352367 0.272101123283862 no 2463 0.301988851266988 3486 2006902
SGTC_3120 9124077 49.47 µM -0.518764012818468 0.272074286792152 no 2464 0.301962658164223 3400 18774327 YGL155W CDC43
SGTC_595 3909-8003 73.7 µM -0.519464283463179 0.271824151222594 no 2465 0.301718506746298 3412 699517
SGTC_537 1334-0398 209 µM -0.52081940841265 0.271340427932706 no 2466 0.30124629071055 3422 5846986
SGTC_2593 nobiletin 86.24 µM -0.520967547964813 0.271287574291252 no 2467 0.301194689186503 3328 72344 An anti-infammatory.
SGTC_271 rotenone 740 µM -0.52167121901523 0.271036586674759 no 2468 0.300949633496464 3436 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_140 0062-0056 502.533 µM -0.521671513055037 0.271036481819926 no 2469 0.300949531114955 3292 3758964
SGTC_646 4092-0839 27.3 µM -0.522798601457587 0.270634709931017 no 2470 0.300557206478083 3460 877796
SGTC_2360 9040895 200 µM -0.524530360614283 0.270017971939811 no 2471 0.299954854379209 3329 4914414
SGTC_1994 st072947 40.9 µM -0.525119803506003 0.269808211936444 no 2472 0.299749955084643 3414 5286565 YDL195W SEC31
SGTC_1435 4092-0789 56.7 µM -0.525472764694318 0.269682645723361 no 2473 0.2996272907703 3410 2248285
SGTC_908 3448-7491 47.7 µM -0.526178800739626 0.269431560729119 no 2474 0.299381990913682 3351 1203031
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.527282149254263 0.269039415769335 no 2475 0.298998834279313 3375 6312947
SGTC_330 1488-0319 80.1 µM -0.528335419272678 0.268665336820822 no 2476 0.298633276158404 3383 6846614
SGTC_1437 4092-1038 11.6 µM -0.531067136631549 0.267696360682916 no 2477 0.297686128237222 3349 3977136
SGTC_1082 camptothecin 424.86 nM -0.531706815757914 0.267469712831632 no 2478 0.297464535300383 3175 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2630 antimycin a 100 µM -0.533994807427101 0.266659836167812 no 2479 0.29667256330779 3344 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2584 androsterone 48.74 µM -0.535963869769676 0.265963844335087 no 2480 0.295991760538258 3437 2754130 A steroid.
SGTC_922 1866-0035 480 µM -0.536394783400959 0.265811654888615 no 2481 0.295842867973389 3334 3156169
SGTC_1147 3809-1045 12.3 µM -0.536982472769201 0.265604166789337 no 2482 0.295639860531526 3352 325925
SGTC_2348 9022543 33.42 µM -0.53698434518163 0.265603505851507 no 2483 0.295639213840376 3429 3162678 YDL140C RPO21
SGTC_2701 st077767 14.721 µM -0.537310349591298 0.26548844314848 no 2484 0.295526628812996 3383 5721188
SGTC_3173 9105693 49.47 µM -0.540497819941187 0.26436476493507 no 2485 0.294426882016215 3504 17096658
SGTC_473 2-arachidonoylglycerol 10 µM -0.541972926955373 0.263845566483702 no 2486 0.293918578187871 3299 5282280 An endocannabinoid.
SGTC_1160 4092-0570 10.5 µM -0.542771364316242 0.263564754775954 no 2487 0.29364361583368 3393 4994975
SGTC_2066 5222451 176 µM -0.543006009352706 0.263482258742624 no 2488 0.293562832450464 3392 2281147
SGTC_910 3454-3003 490 µM -0.543029590087138 0.263473969003944 no 2489 0.293554714665394 3447 820824
SGTC_2748 diazoxide 86.69 µM -0.543373104291933 0.263353222680138 no 2490 0.293436469980838 3373 3019 A potassium channel activatior.
SGTC_2264 7948757 110.76 µM -0.545463627305473 0.262619006952339 no 2491 0.292717344963331 3312 2971411
SGTC_92 0063-0024 660.874 µM -0.546041828232159 0.26241612121275 no 2492 0.292518592555295 3446 3594437
SGTC_371 0195-0006 7.36 µM -0.548525791565587 0.261545433703411 no 2493 0.291665462346188 3365 3928593
SGTC_3328 9140624 29.0385 µM -0.548586492568382 0.261524175153859 no 2494 0.291644628794175 3454 4904392
SGTC_671 0560-0003 407 µM -0.549792348119071 0.261102047438494 no 2495 0.2912309037911 3356 3238678
SGTC_1868 st057644 42.7 µM -0.549839762311044 0.261085456552751 no 2496 0.291214641740456 3351 688665
SGTC_2148 5546263 113.568 µM -0.550335489521649 0.260912027159028 no 2497 0.291044643334823 3344 792097
SGTC_2868 9035608 32.47 µM -0.552087231140688 0.260299658031522 no 2498 0.290444294919546 3427 6462614
SGTC_102 gallobenzophenone 83.616 µM -0.553972466810321 0.259641450705424 no 2499 0.289798844451683 3510 70837
SGTC_126 0417-1624 672.48 µM -0.555763571322122 0.259016905003999 no 2500 0.289186245876081 3532 41912 YDL195W SEC31
SGTC_1015 4130-4525 82 µM -0.557305728196508 0.258479788748171 no 2501 0.288659281328828 3346 1363237
SGTC_2317 5986382 200 µM -0.558931080929812 0.25791432138128 no 2502 0.288104378257571 3482 877883
SGTC_1325 1431-0015 227 µM -0.559122665240227 0.257847710666941 no 2503 0.288039003650086 3364 1103340
SGTC_3046 9092212 49.47 µM -0.561122678576739 0.257152872335045 no 2504 0.287356954463457 3446 25236637
SGTC_2685 mycophenolic acid 18.85 µM -0.561842771028916 0.256902938672141 no 2505 0.287111574069111 3393 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_614 0462-0418 107 µM -0.561915354120511 0.25687775314646 no 2506 0.287086845989539 3355 5188303
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.562759949759486 0.256584782341241 no 2507 0.286799177825354 3565 16725076
SGTC_1672 st016598 6.51 µM -0.564353832639961 0.256032375482982 no 2508 0.28625667592348 3389 4665860 YNL267W PIK1
SGTC_175 3793-3120 23.7 µM -0.564899157919285 0.255843519554796 no 2509 0.286071178242931 3374 5322297
SGTC_3119 9125183 49.47 µM -0.565327930514957 0.255695078987089 no 2510 0.285925367208159 3328 22695334
SGTC_1338 1486-1223 76 µM -0.565594626649267 0.255602771789774 no 2511 0.285834690713153 3436 3444526
SGTC_1352 1496-0991 99 µM -0.565751853371487 0.255548361616384 no 2512 0.285781240147884 3413 3000039
SGTC_118 0083-0097 135.343 µM -0.566475006249312 0.255298183911769 no 2513 0.285535459394196 3544 5207356
SGTC_2027 5150920 200 µM -0.566767889070185 0.255196896338278 no 2514 0.285435944817573 3411 786715
SGTC_2909 7941780 10.49 µM -0.567174309369689 0.255056378952545 no 2515 0.285297880286403 3505 1243215
SGTC_1616 st002734 56.1 µM -0.567787158723068 0.254844566513872 no 2516 0.285089750175545 3365 4026101
SGTC_3007 9078383 71.4286 µM -0.568666591010607 0.254540778856845 no 2517 0.284791212206027 3391 6496995
SGTC_3008 9078912 71.4286 µM -0.569072540709001 0.254400613202825 no 2518 0.284653456147789 3449 16648731
SGTC_2488 5268135 45.7 µM -0.569249437885774 0.254339547088912 no 2519 0.284593437339077 3446 1270356 YLR208W SEC13
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.569610451067436 0.254214946717496 no 2520 0.284470969224829 3429 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1155 4088-0394 48.2 µM -0.57015156894753 0.254028244831328 no 2521 0.284287450551587 3381 2326248
SGTC_1563 conessine 56.1 µM -0.571282493488335 0.253638274383747 no 2522 0.283904083372951 3515 441082 An anti-amoebic, histamine inhibitor.
SGTC_2760 etidronate 98.04 µM -0.571859477582303 0.253439437354097 no 2523 0.2837085894174 3417 3305 A chelator and antioxidant.
SGTC_1567 st069303 68.4 µM -0.573580714547993 0.252846761337969 no 2524 0.283125782637804 3493 5581319
SGTC_3264 9137442 49.47 µM -0.57416409059273 0.252646052292839 no 2525 0.282928383317216 3549 17015726
SGTC_2256 7954252 200 µM -0.574988849082815 0.252362439477441 no 2526 0.282649419247221 3421 2972920
SGTC_2774 tamoxifen 10.92 µM -0.575739511367569 0.252104452364025 no 2527 0.28239563224422 3518 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2000 st075254 36.4 µM -0.575906691122237 0.252047015085741 no 2528 0.282339126350132 3449 17234175
SGTC_1331 1472-0049 76.2 µM -0.576886243482957 0.251710612995571 no 2529 0.282008152063365 3408 24051409
SGTC_2840 9008771 71.43 µM -0.577114762454842 0.251632168149819 no 2530 0.281930966231899 3406 2992978
SGTC_2101 5377231 179.231 µM -0.578075499929593 0.251302512330244 no 2531 0.281606573614008 3472 2844213
SGTC_2202 7226349 200 µM -0.579382728496461 0.250854332722136 no 2532 0.281165477718046 3412 844334
SGTC_3314 9135860 59.4275 µM -0.579593629328103 0.250782065629077 no 2533 0.281094345083851 3497 25252478
SGTC_1761 st044296 37 µM -0.580515204727598 0.25046640878306 no 2534 0.280783618157457 3470 1826700
SGTC_1999 st074831 12.5 µM -0.581031389582309 0.250289697834379 no 2535 0.280609649075246 3399 17112523
SGTC_3121 9125696 49.47 µM -0.582305192924735 0.249853906431914 no 2536 0.280180564140059 3522 1235365
SGTC_2657 nystatin 74.44 µM -0.582550262651733 0.24977010982565 no 2537 0.280098048058186 3500 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2605 digitonin 300 nM -0.583162839914129 0.249560716780941 no 2538 0.279891842061317 3571 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_52 0329-0193 875 nM -0.584136902928875 0.249227951713289 no 2539 0.279564104276236 3564 3739292
SGTC_1025 k007-0731 70 µM -0.586283185071693 0.248495559878642 no 2540 0.278842614411114 3398 6256118
SGTC_2391 6285546 200 µM -0.586420089972758 0.248448881740726 no 2541 0.27879662349612 3393 846083
SGTC_2451 5856223 45.7 µM -0.587099008290342 0.248217471557262 no 2542 0.278568606791496 3444 2179896
SGTC_235 0330-0087 5 mM -0.587387283905269 0.248119247217461 no 2543 0.278471816061326 3495 46494818 YHR062C RPP1
SGTC_1992 st073643 23.3 µM -0.58803351429204 0.247899132068291 no 2544 0.278254898848101 3484 3161292
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.588160905976599 0.247855752971831 no 2545 0.27821214758365 3393 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2741 miltefosine 3.04 µM -0.589953845212892 0.247245655868511 no 2546 0.277610796657977 3413 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2399 5884133 200 µM -0.590216626007314 0.247156304961236 no 2547 0.277522713497326 3453 722445
SGTC_2734 clemastine 41.6 µM -0.592185110931058 0.246487528934504 no 2548 0.276863319267516 3439 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_17 0960-0276 49.807 µM -0.59254623267824 0.246364946229753 no 2549 0.276742435671037 3520 6821114
SGTC_3275 9138069 49.47 µM -0.592645883506058 0.246331125529539 no 2550 0.276709082635915 3513 17617007
SGTC_795 0685-0265 78 µM -0.593326045788405 0.246100350328275 no 2551 0.276481485595807 3578 302754
SGTC_1063 disulfiram 1.84 µM -0.593348009883709 0.246092899968788 no 2552 0.276474137463736 3495 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2812 7970281 58.44 µM -0.593506076241479 0.246039286432919 no 2553 0.276421258871721 3551 2233435
SGTC_3242 9133940 49.47 µM -0.594896596359928 0.245567914780882 no 2554 0.275956296285451 3561 17248444
SGTC_2522 biochanin a 4.94 µM -0.598724749006817 0.244272721365809 no 2555 0.274678225255554 3513 5280373 A possible chelator.
SGTC_2455 5377712 9.75 µM -0.598906306332283 0.244211385983681 no 2556 0.274617682919218 3478 2243908
SGTC_1343 1487-0095 224 µM -0.599596417684962 0.243978321940055 no 2557 0.274387617586955 3525 4560101 YGL055W OLE1
SGTC_3062 9077494 49.47 µM -0.599969617304881 0.24385233516991 no 2558 0.274263242103869 3489 16459633
SGTC_1671 st016596 74.5 µM -0.600740762786042 0.243592118922942 no 2559 0.274006332234351 3552 2829167
SGTC_3334 9142812 21.919 µM -0.601884457055767 0.243206465665254 no 2560 0.273625525535587 3530 45283678
SGTC_1340 1486-1359 257 µM -0.602772965183736 0.242907089047062 no 2561 0.273329866967239 3443 4309068
SGTC_1173 0443-0020 122 µM -0.602941467663342 0.24285033581213 no 2562 0.273273814199966 3492 5331295
SGTC_2157 5649910 96.377 µM -0.604486501163632 0.24233028854716 no 2563 0.272760120595104 3494 2858091
SGTC_2784 7567673 72.73 µM -0.605910060883324 0.241851663169309 no 2564 0.272287239112318 3553 3471247
SGTC_2167 5876490 200 µM -0.606316309637674 0.241715169452186 no 2565 0.272152365176529 3553 686534
SGTC_1652 st011932 78 µM -0.606784647359225 0.241557866639022 no 2566 0.271996919024499 3505 1551076
SGTC_2254 7938975 95.19 µM -0.606969854880392 0.241495675451337 no 2567 0.271935458911249 3592 2969277
SGTC_2991 9074669 71.4286 µM -0.607773095496583 0.241226054417641 no 2568 0.271668987833614 3541 17333109
SGTC_665 3914-0008 307 µM -0.612193176451078 0.239745312366388 no 2569 0.270204977822115 3492 1069549
SGTC_303 1348-1668 34.2 µM -0.612284993867622 0.23971460589345 no 2570 0.270174608130638 3521 5380509
SGTC_2240 6690706 185.951 µM -0.61325879854622 0.239389068789126 no 2571 0.269852615875805 3454 805876
SGTC_379 3970-0972 5.9 µM -0.616622394535079 0.238266498278257 no 2572 0.268741909884356 3515 2898042 YBL034C STU1
SGTC_881 0833-0569 170 µM -0.617052058956483 0.238123309556912 no 2573 0.268600194335917 3472 5418700
SGTC_268 camptothecin 39.6153 µM -0.619146708621848 0.23742592843635 no 2574 0.26790985758461 3572 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1214 0358-0031 63.7 µM -0.619431997921165 0.237331032623205 no 2575 0.26781590355989 3594 4301366
SGTC_2333 9017922 200 µM -0.619557417500902 0.237289320885532 no 2576 0.267774604514972 3558 3163164
SGTC_684 1140-0066 328 µM -0.620699122735989 0.23690980054827 no 2577 0.267398803367012 3558 6813534
SGTC_793 0488-0545 106 µM -0.620994798444275 0.23681156783498 no 2578 0.267301522798339 3468 292548
SGTC_215 1287-0124 461.5 µM -0.621682984609185 0.23658301763508 no 2579 0.267075171132034 3522 5560863
SGTC_1668 st014914 51.6 µM -0.621943756526891 0.236496445644647 no 2580 0.266989425797406 3559 2839556
SGTC_2895 9054447 58.44 µM -0.622472606546483 0.236320929673928 no 2581 0.266815575455715 3558 2697450
SGTC_638 3970-0837 4.09 µM -0.622818909578091 0.236206036690653 no 2582 0.266701765295462 3519 4118451 YLR208W SEC13
SGTC_2005 4024620 188 µM -0.624466417750841 0.235659864327368 no 2583 0.266160659108419 3566 236743
SGTC_331 k048-0133 24.5 µM -0.624642768906875 0.235601442712333 no 2584 0.266102771435557 3547 6813582
SGTC_225 nsc-122657 1.016 µM -0.624945790100634 0.235501076505114 no 2585 0.266003318923142 3512 275685
SGTC_229 benomyl 22.8748 µM -0.625326224087873 0.235375103162185 no 2586 0.265878485950841 3562 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_209 4077-0173 175.592 µM -0.626602947299068 0.234952612991406 no 2587 0.265459767944481 3504 15993494
SGTC_1391 3442-0225 151 µM -0.627835510405266 0.234545134040777 no 2588 0.265055850482821 3517 5227075
SGTC_2017 5132927 60.65 µM -0.628339995697509 0.23437846663732 no 2589 0.264890618071903 3520 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_203 k066-0004 30.888 µM -0.629718054445732 0.233923529944969 no 2590 0.264439533995001 3626 6795412
SGTC_143 4032-1194 15.74 µM -0.630249137424173 0.233748334923781 no 2591 0.264265797444994 3573 1806963
SGTC_1388 3346-4487 254 µM -0.630665242808372 0.233611119838283 no 2592 0.264129714868206 3580 3345614
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.631933496003353 0.233193175779692 no 2593 0.263715167280604 3610 368090
SGTC_2474 5321570 43.32 µM -0.63217023127071 0.233115207305429 no 2594 0.263637823575814 3549 2841384
SGTC_2411 st077133 39.94 µM -0.634049194863473 0.232496886505076 no 2595 0.263024358677144 3663 1403142 YNL221C POP1
SGTC_77 0828-0286 12.516 µM -0.63445730510932 0.232362708097083 no 2596 0.262891210820024 3560 745345
SGTC_2790 5423970 71.43 µM -0.634567651617179 0.232326435793035 no 2597 0.262855215680718 3595 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.63777086898136 0.231274871394341 no 2598 0.261811422591484 3625 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2184 6075246 200 µM -0.637932374153198 0.23122192226238 no 2599 0.261758851241907 3568 2267320
SGTC_1744 st037937 38.9 µM -0.640577497151659 0.230355687311097 no 2600 0.260898611858352 3610 1016152
SGTC_2927 9011802 47.9 µM -0.641684477942895 0.229993708319124 no 2601 0.260539034784639 3561 43912568
SGTC_1958 st076513 41.9 µM -0.642547262767154 0.229711801473492 no 2602 0.260258956156508 3518 732122 YGL099W LSG1
SGTC_942 3253-1115 227 µM -0.643851182574642 0.229286125377179 no 2603 0.259835970170493 3621 46497897
SGTC_454 lyso-paf C-16 6.67 µM -0.644418897213588 0.229100928222882 no 2604 0.259651916872184 3527 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1399 3562-5772 25 µM -0.645348480666738 0.228797865208956 no 2605 0.259350690952906 3547 23847490
SGTC_3224 9130643 49.47 µM -0.645661397627367 0.228695898599536 no 2606 0.259249332729832 3635 17644395
SGTC_1806 st050005 60.3 µM -0.645664788442419 0.228694793813848 no 2607 0.259248234509079 3545 5194765
SGTC_196 k015-0023 18.111 µM -0.646361131716238 0.228467976742982 no 2608 0.259022753073269 3576 5211998
SGTC_1836 st055642 81 µM -0.646380478074989 0.228461676936949 no 2609 0.259016490018292 3528 8571
SGTC_722 3534-0461 190 µM -0.647164438666386 0.228206475895164 no 2610 0.258762762000184 3565 658262
SGTC_3295 9122362 53.5725 µM -0.647661646638297 0.228044703920049 no 2611 0.258601907854005 3585 4730473
SGTC_2692 st077426 47.7 µM -0.648035314030549 0.227923169666504 no 2612 0.258481055001218 3585 25238571
SGTC_598 3937-0236 20.2 µM -0.648736835348462 0.227695100311762 no 2613 0.258254245493506 3606 1379313
SGTC_2426 5582046 32.21 µM -0.649023912012072 0.227601806789719 no 2614 0.258161460223777 3609 2251934
SGTC_1605 st000082 49.1 µM -0.649461555634724 0.227459623783376 no 2615 0.258020043880206 3593 1114022
SGTC_2978 9011784 42.97 µM -0.64954880597758 0.227431283605996 no 2616 0.257991855369664 3641 2994934
SGTC_1695 st026914 34.495 µM -0.650294458940063 0.227189165853455 no 2617 0.257751017809151 3567 3289191
SGTC_2417 cerulenin 830 nM -0.651164738440732 0.226906764975503 no 2618 0.257470074930883 3660 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_929 2805-0021 398 µM -0.651403424625209 0.226829347242441 no 2619 0.257393050270023 3603 3098024
SGTC_3316 9136639 10.545 µM -0.652231061111106 0.22656101924949 no 2620 0.257126062561294 3588 4903665
SGTC_2694 st077685 81.9 µM -0.653849101237924 0.226036952473312 no 2621 0.256604514396694 3573 2838096
SGTC_40 0327-0103 19.753 µM -0.654189136492572 0.225926905702989 no 2622 0.256494979820637 3532 409036
SGTC_628 1636-0253 16 µM -0.654313232384898 0.225886751672065 no 2623 0.256455011236369 3581 4456143
SGTC_2378 9074213 121.43 µM -0.655162134745417 0.225612178375299 no 2624 0.256181685322479 3599 657714
SGTC_481 bay k-8644 50 µM -0.655252084922108 0.225583095502808 no 2625 0.256152732456029 3551 2303 A calcium channel antagonist.
SGTC_1044 1222-0021 1.78 µM -0.655654188879417 0.225453112383817 no 2626 0.256023325425664 3562 4306703
SGTC_166 k072-0058 166.424 µM -0.656194458609261 0.22527853291563 no 2627 0.25584950693195 3624 5846229
SGTC_786 4544-0069 423 µM -0.656311737803279 0.225240646147548 no 2628 0.255811783374407 3598 748821 YLR208W SEC13
SGTC_3055 9094636 49.47 µM -0.656813844129983 0.225078482683957 no 2629 0.25565031068621 3648 25236176
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.659005471045494 0.224371435924351 no 2630 0.254946127714548 3639 165521
SGTC_173 1273-0061 2.693 µM -0.660926469205695 0.223752735607286 no 2631 0.254329735147833 3566 2847414 YPL266W DIM1
SGTC_2213 7173844 200 µM -0.661758826799204 0.223484957728216 no 2632 0.254062898530795 3598 892728
SGTC_1643 st009866 20.2 µM -0.664055019646015 0.222747195088038 no 2633 0.253327548737208 3612 3156273 YOR207C RET1
SGTC_179 1273-0063 6.77 µM -0.664118092136958 0.222726949615414 no 2634 0.253307365736427 3587 3108139
SGTC_409 arachidonic acid 100 µM -0.66451319392048 0.222600150798945 no 2635 0.253180953632267 3640 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_508 roscovitine 141 µM -0.665927348776021 0.222146647778778 no 2636 0.252728769363039 3653 160355 A CDKinase inhibitor.
SGTC_1217 1183-1422 255 µM -0.666602890682636 0.221930195596332 no 2637 0.252512911090919 3645 2849664
SGTC_1764 st044502 93.5 µM -0.668492239345765 0.221325464214102 no 2638 0.251909717051807 3630 8407
SGTC_2043 5101342 149 µM -0.671697914051485 0.220301570077152 no 2639 0.250888014800817 3618 678451
SGTC_1416 3966-0321 25.3 µM -0.67180151059248 0.2202685266511 no 2640 0.25085503347326 3637 582530 YLR208W SEC13
SGTC_3073 9114972 49.47 µM -0.672375934916675 0.220085358324537 no 2641 0.25067219955366 3557 41905075
SGTC_1550 gossypolone 36.6 µM -0.673721713563446 0.219656568349828 no 2642 0.250244127252324 3640 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_226 1,3-diallylurea 8.28947 mM -0.674360901120597 0.219453079515392 no 2643 0.25004094699676 3594 74537 YKL182W FAS1
SGTC_499 genistein 192 µM -0.674490759476595 0.219411751642024 no 2644 0.249999679274407 3643 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_5 0352-0601 109.883 µM -0.674613906908124 0.219372563675188 no 2645 0.249960547557618 3553 762456
SGTC_16 erodoxin 22.806 µM -0.674734733250012 0.219334118234506 no 2646 0.249922156557081 3662 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_163 TUB2.036 7.546 µM -0.674844134216311 0.219299311546682 no 2647 0.249887398521006 3657 15992207 YJR013W GPI14
SGTC_204 PMA1.184 62.41 µM -0.67512864287406 0.21920880797795 no 2648 0.249797018626463 3663 2252213 YGL008C PMA1
SGTC_86 0417-1630 471.922 µM -0.675258600176078 0.219167475081477 no 2649 0.24975574085212 3673 3634867
SGTC_2128 5255449 168.493 µM -0.676316589734764 0.218831148451964 no 2650 0.249419831026383 3648 736008
SGTC_482 fipronil 114 µM -0.676481960537571 0.218778605212712 no 2651 0.249367347794875 3662 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2945 9067681 61.76 µM -0.676796505893217 0.218678684805832 no 2652 0.249267537690999 3714 16456930
SGTC_408 cantharidin 100 µM -0.678063277458543 0.218276540390821 no 2653 0.248865786620222 3614 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2782 7736369 71.43 µM -0.678159945685606 0.218245869976199 no 2654 0.248835142875201 3690 2950836 YOL077C BRX1
SGTC_2120 5538279 151.968 µM -0.67944843161335 0.217837302757687 no 2655 0.248426885835691 3660 2058197
SGTC_2553 4-methylesculetin 85.09 µM -0.682177021056066 0.216973549544336 no 2656 0.247563511478225 3668 5319502
SGTC_3130 9127414 49.47 µM -0.682231314610773 0.216956382666696 no 2657 0.247546348309657 3660 1494646
SGTC_1221 2958-7315 257 µM -0.68285150568228 0.216760342461534 no 2658 0.247350339877334 3655 4562705
SGTC_3185 9108267 49.47 µM -0.68384578151682 0.216446269226493 no 2659 0.247036276932152 3619 4910486
SGTC_2385 9074692 200 µM -0.684087112418783 0.216370077021784 no 2660 0.246960079676716 3651 17046906
SGTC_335 4077-0256 27.6 µM -0.685691246830717 0.21586401963559 no 2661 0.246453913818524 3675 3121989
SGTC_1238 0333-0287 48.8 µM -0.687391859761704 0.215328275873685 no 2662 0.245917912959573 3666 7226
SGTC_1971 st069429 63.5 µM -0.68787103478028 0.215177460897349 no 2663 0.245766999150646 3654 1246522 YGL099W LSG1
SGTC_55 0767-0285 6.563 µM -0.68906630314539 0.214801530887684 no 2664 0.24539077207192 3636 3116166
SGTC_105 0111-0055 734.78 µM -0.689270107792725 0.214737469337603 no 2665 0.245326652671159 3627 5179370
SGTC_3204 9114183 49.47 µM -0.690812500247015 0.214253011931898 no 2666 0.244841689503103 3676 17027248
SGTC_890 0929-0006 47.2 µM -0.692485021535799 0.213728400977408 no 2667 0.244316394548871 3657 1378169
SGTC_103 0844-0104 51.839 µM -0.69256493552288 0.213703353520395 no 2668 0.244291310881336 3703 5375804
SGTC_949 1165-0505 146 µM -0.692689416352505 0.213664340875268 no 2669 0.244252241190765 3703 6244267
SGTC_383 2324-0395 7.37 µM -0.693515975698552 0.21340540008999 no 2670 0.243992901824852 3668 3146421
SGTC_900 1112-0045 141 µM -0.694144284526863 0.213208688765222 no 2671 0.243795864506519 3588 56211 YIL048W NEO1
SGTC_2262 9014885 67.46 µM -0.694473153414003 0.213105768460149 no 2672 0.243692765648158 3606 6457424
SGTC_1330 1469-0054 61.8 µM -0.696179379626168 0.21257226629938 no 2673 0.243158249782643 3684 7102664
SGTC_1937 st074714 47.2 µM -0.697406676305682 0.212188998468037 no 2674 0.242774162286691 3644 17250970
SGTC_3093 9117344 49.47 µM -0.697954416246392 0.212018077297557 no 2675 0.242602850878368 3666 24824913
SGTC_3292 9120825 59.784 µM -0.700394640575864 0.211257589137863 no 2676 0.241840441173403 3687 24824900
SGTC_1014 4130-3005 69.3 µM -0.701823715341774 0.210812965529932 no 2677 0.241394553582989 3698 743608
SGTC_2183 6420625 130.508 µM -0.702102335795243 0.210726343186258 no 2678 0.24130767288463 3691 2897619
SGTC_1281 0884-0031 11.8 µM -0.703040618667661 0.210434787174421 no 2679 0.241015218243615 3703 1548255
SGTC_2091 4-phenylthiadiazole 200 µM -0.703664271686038 0.210241128299024 no 2680 0.240820937687297 3686 270010
SGTC_822 1487-0950 154 µM -0.703810461553973 0.210195748066805 no 2681 0.240775408911193 3677 1958375
SGTC_1047 2043-3044 82 µM -0.704778824394287 0.209895294351741 no 2682 0.24047394424162 3685 669592
SGTC_708 3448-5400 146 µM -0.706224995396812 0.20944706148983 no 2683 0.240024114299326 3670 3462195
SGTC_3286 9117135 37.221 µM -0.706879550760845 0.209244370882651 no 2684 0.239820666476698 3668 3438150
SGTC_1200 1643-0193 18.4 µM -0.707869531128348 0.208938031535982 no 2685 0.2395131412297 3695 5403974
SGTC_96 0929-0093 37.281 µM -0.7099914926972 0.208282302838349 no 2686 0.238854705874682 3659 6991579
SGTC_1390 3413-2614 145 µM -0.713611973852486 0.207166308699963 no 2687 0.237733575682763 3740 3421432
SGTC_3095 9117207 49.47 µM -0.7157976272323 0.206494308104685 no 2688 0.237058158879949 3672 17015229
SGTC_1222 0366-0074 1.18 µM -0.715918990228143 0.206457031741687 no 2689 0.237020685870428 3728 286520
SGTC_2820 7989630 71.43 µM -0.720546045493104 0.205038818086337 no 2690 0.235594430034591 3598 2984098
SGTC_2531 methyl deoxycholate 70.07 µM -0.722031856181534 0.204584641474772 no 2691 0.235137446039875 3707 16667744 Haematoxylin.
SGTC_153 4077-0274 519.67 µM -0.724224738090251 0.203915424964423 no 2692 0.234463886765179 3772 3121976
SGTC_1913 st060213 96.1 µM -0.725091173353932 0.203651369047559 no 2693 0.234198049517209 3724 688959
SGTC_1865 st057639 52.2 µM -0.725125733245654 0.203640840761106 no 2694 0.234187449409703 3709 688818
SGTC_1759 st043059 70 µM -0.727828996841399 0.202818327539652 no 2695 0.233359135911894 3719 669426
SGTC_221 trifluoperazine 10.304 µM -0.728644650158484 0.202570541664162 no 2696 0.233109529225045 3723 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2940 9060638 45.86 µM -0.729694866735087 0.202251764865613 no 2697 0.232788359776072 3737 4027022
SGTC_2031 5180455 200 µM -0.732340932505525 0.201449924644142 no 2698 0.231980250778753 3714 29949
SGTC_1133 3473-0247 50 µM -0.733135277229158 0.201209585782214 no 2699 0.231737962944474 3753 711311
SGTC_887 0885-0007 9.62 µM -0.733814223858674 0.201004298386246 no 2700 0.231530985178664 3781 5719458
SGTC_1417 3966-0327 90.4 µM -0.734509413487578 0.200794229972615 no 2701 0.23131916253772 3799 651118
SGTC_1295 1013-0063 9.78 µM -0.735065436116472 0.20062630911864 no 2702 0.231149821581674 3734 6826038
SGTC_353 1988-1175 58.3 µM -0.735281793084128 0.200560991321626 no 2703 0.231083947108088 3598 2788357
SGTC_2386 9075165 157.42 µM -0.737426297722734 0.199914259868256 no 2704 0.230431574028678 3706 16452277
SGTC_258 haloperidol 50.781 µM -0.739149223776719 0.199395576111616 no 2705 0.229908194791446 3757 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_783 0848-0141 92.7 µM -0.739985419716912 0.199144133149147 no 2706 0.229654420690297 3723 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_223 busulfan 5 mM -0.742023874004716 0.19853197364437 no 2707 0.229036435469273 3734 2478 A DNA alkylator.
SGTC_1725 st036284 20.55 µM -0.742217025144602 0.198474028182933 no 2708 0.228977927493911 3773 707914
SGTC_2315 7733312 200 µM -0.742521757424743 0.198382629060533 no 2709 0.228885637204459 3707 726316
SGTC_1168 k815-0004 80.5 µM -0.743635437262782 0.198048816337244 no 2710 0.228548529147285 3727 642433
SGTC_589 1227-0070 34.1 µM -0.743944155521651 0.197956341669765 no 2711 0.228455130308562 3753 2841384
SGTC_265 mycophenolic acid 32.932 µM -0.74428035723302 0.197855664173847 no 2712 0.22835344109349 3827 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1827 berberine 7.24 µM -0.74510153628182 0.197609887567787 no 2713 0.228105170234606 3687 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_573 3702-0553 84.7 µM -0.745186886463853 0.197584353087235 no 2714 0.228079374630322 3711 1222756
SGTC_2094 5332512 191.667 µM -0.746002160095486 0.197340545661736 no 2715 0.22783305508465 3797 755774
SGTC_954 1189-0853 2.85 µM -0.746564163666123 0.197172584598186 no 2716 0.227663343508477 3720 2828194
SGTC_1614 st002383 48.6 µM -0.749192802984845 0.196388135360492 no 2717 0.226870503180904 3747 1947235
SGTC_2980 9014342 25.29 µM -0.749438044604093 0.19631504595784 no 2718 0.226796613839386 3792 2996599
SGTC_3151 9099821 49.47 µM -0.749505022697022 0.196295087332229 no 2719 0.226776436235485 3706 17174189
SGTC_2598 perillyl alcohol 100 µM -0.749943667062315 0.196164407263381 no 2720 0.226644316691426 3768 10819 An apoptosis inducer.
SGTC_202 3594-0513 34.79 µM -0.750108451107739 0.196115328759125 no 2721 0.226594695016999 3738 708429
SGTC_2328 6201408 200 µM -0.750466041578016 0.196008851314688 no 2722 0.22648703434206 3768 2890418
SGTC_1021 4476-0760 85.3 µM -0.751291080997474 0.195763318395972 no 2723 0.226238747843908 3770 746768
SGTC_1116 jasmonic acid 1.58368 µM -0.752103414204376 0.195521749344303 no 2724 0.225994435455174 3772 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.754793187318113 0.194723166178795 no 2725 0.225186541109057 3782 23847180
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.755990693394737 0.194368270561437 no 2726 0.224827387796049 3768 688798
SGTC_1777 st045864 34.765 µM -0.756693491898991 0.19416017110131 no 2727 0.224616757381996 3756 4691462
SGTC_1518 st038567 90.8 µM -0.758259450598065 0.193696977220804 no 2728 0.22414783857986 3756 77966
SGTC_1667 st014849 34.6 µM -0.760268523801679 0.193103702464988 no 2729 0.223547046272469 3825 5348460
SGTC_1719 st032227 49.2 µM -0.762942431915316 0.192315826473862 no 2730 0.22274886455798 3798 3125804
SGTC_1969 st069479 40.1 µM -0.764291719252759 0.191919001848616 no 2731 0.22234670949222 3757 3895485
SGTC_281 1672-3440 14.9 µM -0.765250300310131 0.191637388463332 no 2732 0.222061256253601 3821 6833000
SGTC_749 1000-0129 128 µM -0.76648782849615 0.191274200081569 no 2733 0.221693045674889 3817 708470
SGTC_848 0368-0089 85.6 µM -0.768793574063071 0.190598638784877 no 2734 0.221007932110345 3775 762535
SGTC_2028 5153890 36.43 µM -0.76918729524477 0.190483428842978 no 2735 0.220891065720165 3747 2830968 YPR165W RHO1
SGTC_1084 voriconazole 435 nM -0.770151779441976 0.190201384042825 no 2736 0.220604931986885 3777 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_66 0109-0187 42.4 µM -0.771147877446411 0.189910363887831 no 2737 0.220309642401051 3768 759417
SGTC_511 blebbistatin 171 µM -0.772047172602727 0.189647860945456 no 2738 0.220043244414753 3832 3476986 A myosin inhibitor.
SGTC_467 ro 31-8220 72.8 µM -0.773036300107728 0.189359393968282 no 2739 0.2197504489392 3725 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2865 9030313 51.95 µM -0.773120486287967 0.189334854573108 no 2740 0.219725538993653 3735 42562754
SGTC_59 0330-0160 1.33 µM -0.773371037862608 0.189261832980486 no 2741 0.219651412593399 3759 4293482
SGTC_3179 9107801 49.47 µM -0.774498537312521 0.188933445370831 no 2742 0.219318016417138 3793 4818259
SGTC_2296 7971656 126.45 µM -0.775480665500463 0.188647683832643 no 2743 0.219027842967307 3858 666570
SGTC_125 0133-0007 11.75 µM -0.776239277437909 0.188427139420429 no 2744 0.218803859447945 3873 26541
SGTC_1635 st007035 42.4 µM -0.776258527383968 0.188421545126702 no 2745 0.218798177531682 3784 3716403
SGTC_2648 atorvastatin 78.68 µM -0.777227958585683 0.188139947850616 no 2746 0.2185121448923 3787 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3199 9111318 49.47 µM -0.777525717292588 0.188053508018602 no 2747 0.218424333825225 3766 8548020
SGTC_2856 9022925 19.48 µM -0.778393020503019 0.187801868225897 no 2748 0.218168676057848 3824 4944862
SGTC_774 k060-0086 136 µM -0.779023463614092 0.187619081731949 no 2749 0.217982946593862 3805 5911235
SGTC_1557 sumaresinolic acid 42.3 µM -0.779704622681746 0.187421714572498 no 2750 0.217782378629893 3754 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1736 st036774 51 µM -0.783666769619006 0.186276220831887 no 2751 0.216617833012658 3900 1272247
SGTC_3320 9137005 35.139 µM -0.784673290379613 0.185985918687927 no 2752 0.216322573402442 3839 4908713
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.785320879508021 0.185799288493539 no 2753 0.216132728453168 3813 91467 include heat shock
SGTC_1631 benzylvanillin 81.9 µM -0.785860367767421 0.185643900861818 no 2754 0.215974647672782 3872 75506
SGTC_2096 5468907 200 µM -0.786581175108544 0.185436414165777 no 2755 0.215763541372644 3851 759785
SGTC_3126 9127922 49.47 µM -0.787019654413044 0.185310266942692 no 2756 0.215635180369411 3811 45595682
SGTC_2237 6667747 47.222 µM -0.787400329420883 0.185200792804569 no 2757 0.215523776986739 3790 729940 YDL015C TSC13
SGTC_1847 st056231 15 µM -0.789142551028205 0.184700279185364 no 2758 0.215014347293836 3819 5393180
SGTC_2557 derrustone 83.84 µM -0.790339570852403 0.184356881569891 no 2759 0.214664741491872 3772 629853 An antioxidant.
SGTC_1832 st054113 55 µM -0.792111391646187 0.183849316380531 no 2760 0.214147864184079 3768 1251267
SGTC_1085 doxorubicin 7.67 µM -0.793576558400427 0.183430255047473 no 2761 0.213720991848079 3816 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1403 3909-7815 62.9 µM -0.794416746906425 0.18319021643326 no 2762 0.213476428983117 3774 6615483
SGTC_655 k060-0012 42 µM -0.794816138031533 0.18307618066265 no 2763 0.213360231054389 3818 5994525
SGTC_952 1185-0122 232 µM -0.797558434812461 0.182294385433996 no 2764 0.212563389908364 3774 678600
SGTC_2826 7992541 19.48 µM -0.799055573054283 0.181868451374546 no 2765 0.212129094432366 3871 2985066
SGTC_2854 9024559 71.43 µM -0.79925119107705 0.181812844293325 no 2766 0.212072387169439 3865 3163529
SGTC_3020 9089140 49.47 µM -0.799270106150026 0.181807467990757 no 2767 0.212066904392076 3897 17217859
SGTC_2180 6301957 200 µM -0.799990233484095 0.181602857450861 no 2768 0.211858227871607 3773 845462
SGTC_1952 st077036 64.1 µM -0.803977702565607 0.180472503471804 no 2769 0.210704926252493 3831 2937007
SGTC_3221 9128209 49.47 µM -0.804165835313454 0.180419281504082 no 2770 0.210650603476808 3877 16460723
SGTC_3319 9138450 16.7555 µM -0.806415861726878 0.179783521727118 no 2771 0.210001552051245 3783 2029690
SGTC_542 3381-0244 89.3 µM -0.806573804364592 0.179738946919934 no 2772 0.209956035481803 3887 1112843
SGTC_1885 st057546 99.9 µM -0.806846580372598 0.179661980019911 no 2773 0.209877439405892 3911 702008
SGTC_2361 9034121 116 µM -0.807374979005545 0.179512945169855 no 2774 0.209725238934458 3847 6496917
SGTC_3249 9135183 49.47 µM -0.808168646821877 0.17928923720345 no 2775 0.209496752049333 3841 4902779
SGTC_681 1642-0006 26.6 µM -0.809685795115399 0.178862092809935 no 2776 0.209060392072225 3858 4446530
SGTC_3148 9097893 49.47 µM -0.811416037423524 0.178375735506163 no 2777 0.208563396175359 3859 17174100
SGTC_2736 butenafine 14.65 µM -0.812410038961828 0.178096706812337 no 2778 0.208278193857336 3804 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_349 k015-0014 24 µM -0.816189338057351 0.177038324018418 no 2779 0.207195926935611 3850 2196908
SGTC_1763 st044482 94.5 µM -0.817797397851226 0.176589198745472 no 2780 0.206736442079643 3897 88505
SGTC_721 1187-1332 279 µM -0.819119012637865 0.176220616466796 no 2781 0.206359257708116 3799 25730
SGTC_2478 5763493 32.33 µM -0.823486867223586 0.175005941778134 no 2782 0.205115591178239 3819 1365576 YLR208W SEC13
SGTC_2845 9003024 42.97 µM -0.824145634837677 0.174823204476523 no 2783 0.204928406504168 3892 2990173
SGTC_230 MPP+ 141.667 µM -0.824966746289602 0.17459560380702 no 2784 0.204695235092899 3864 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_98 0074-0023 107.663 µM -0.825794399417258 0.174366380381253 no 2785 0.204460365825282 3840 3563821
SGTC_2634 4'-methoxyflavone 100 µM -0.826851426741805 0.174073908565865 no 2786 0.204160638690433 3886 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_364 0083-0097 67.7 µM -0.826855288668855 0.174072840570677 no 2787 0.204159544095332 3967 5207356
SGTC_2440 5628896 157.78 µM -0.827569076432197 0.173875517931187 no 2788 0.203957293574618 3884 5522048
SGTC_2122 5258151 111.688 µM -0.828057230452826 0.173740652418706 no 2789 0.203819044751554 3873 2173356
SGTC_3223 9129970 49.47 µM -0.829766961605945 0.173268818639022 no 2790 0.203335276867177 3901 17248386
SGTC_411 enrofloxacin 100 µM -0.834504971514098 0.17196554023946 no 2791 0.201998243515928 3978 71188 A bacterial gyrase inhibitor.
SGTC_2536 dehydroabietamide 32.04 µM -0.835267223730055 0.171756454423666 no 2792 0.201783633703278 3939 3983547
SGTC_1309 pyrazolanthrone 13.4 µM -0.836807285540489 0.171334511074482 no 2793 0.201350450767731 3886 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1493 4348-0038 111 µM -0.837383520279749 0.171176805819435 no 2794 0.201188512982938 3884 800424
SGTC_468 gf-109203x 121 µM -0.838181780359821 0.170958489573456 no 2795 0.200964309054274 3841 2396 A protein kinase C inhibitor.
SGTC_1878 temozolomide 1 mM -0.838747565158171 0.170803860939487 no 2796 0.200805490282804 3793 5394 DNA alkylating agent.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.84092292736096 0.170210169745771 no 2797 0.200195556591829 3863 390807
SGTC_220 paclitaxel 373.376 µM -0.841518667095434 0.170047813733842 no 2798 0.200028715947347 3837 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1666 st014829 29 µM -0.841777909289853 0.169977193871794 no 2799 0.199956139657395 3893 3858230
SGTC_141 0443-0274 32.331 µM -0.841800942688949 0.169970920280092 no 2800 0.199949692095587 3938 1627241
SGTC_501 nsc-95397 161 µM -0.8438909164175 0.169402293331316 no 2801 0.199365182289056 3934 262093
SGTC_682 0kpi-0099 17 µM -0.844371373698174 0.169271746315056 no 2802 0.19923095680703 3940 1714895 YML126C ERG13
SGTC_2775 cyproheptadine 69.59 µM -0.845619037210555 0.168933040252241 no 2803 0.198882650985726 3897 2913 A selective serotonin reuptake inhibitor.
SGTC_785 1270-0111 65.3 µM -0.846582143938246 0.168671881431553 no 2804 0.198614035056995 3839 6741994
SGTC_2156 5649887 115 µM -0.846685960225767 0.1686437458066 no 2805 0.198585093175621 3943 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2944 9067346 25.62 µM -0.846963648702924 0.168568503281884 no 2806 0.198507691746791 3828 6473075
SGTC_675 1309-0189 238 µM -0.847003943703957 0.168557586733726 no 2807 0.198496461641903 3922 4246530
SGTC_1662 st014054 52 µM -0.851634719779913 0.167306064624731 no 2808 0.197208431502936 3915 2838777
SGTC_2037 5169046 200 µM -0.852218888690767 0.167148612543611 no 2809 0.197046307418568 3973 5718022
SGTC_2756 carbadox 75.1 µM -0.855360753990271 0.166303419285294 no 2810 0.196175731669978 3912 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1637 st007924 17.4 µM -0.855552349485429 0.166251967617287 no 2811 0.196122718261909 3866 683336
SGTC_1213 1315-0166 115 µM -0.858949743498555 0.165341328351768 no 2812 0.195184121821481 4006 768401
SGTC_2866 9034245 58.44 µM -0.861356289052775 0.164698233176327 no 2813 0.194520921282486 3893 6462273
SGTC_2693 st077581 40.7 µM -0.862356248961253 0.164431493605235 no 2814 0.194245754188257 3978 25238761
SGTC_1102 cgs 12066b 26.1 µM -0.864397782425666 0.163887784006206 no 2815 0.193684705331925 3933 6438352 A 5-HT1B full agonist.
SGTC_889 0919-1524 82.7 µM -0.865859690028194 0.163499160415141 no 2816 0.193283555493981 3952 3905452
SGTC_739 1486-1183 203 µM -0.866938977708352 0.163212634241711 no 2817 0.19298772279188 3896 4346692
SGTC_755 1995-0008 37.3 µM -0.867110144444812 0.16316722338563 no 2818 0.1929408314139 3895 689533
SGTC_754 3474-0146 171 µM -0.867390732234463 0.163092800682645 no 2819 0.192863979032575 3906 24762078
SGTC_1231 0242-0792 125 µM -0.867629250953689 0.163029553671345 no 2820 0.192798663983649 3922 3707635
SGTC_3348 9149464 3.537 µM -0.86850988853229 0.162796176808728 no 2821 0.192557630650404 3901 1951442
SGTC_1897 st060201 15 µM -0.86990956702769 0.162425696755472 no 2822 0.192174913381802 3976 611878
SGTC_1805 st050013 60.3 µM -0.872366200922147 0.161776779586461 no 2823 0.191504316518863 3878 4037144
SGTC_7 0192-1582 4.227 µM -0.874124576080683 0.161313345532674 no 2824 0.191025207514436 3972 252616
SGTC_2658 polymyxin b sulfate 77.05 µM -0.874585655498812 0.16119196774881 no 2825 0.190899697778566 3957 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3000 9075062 71.4286 µM -0.875382809106425 0.160982260029092 no 2826 0.190682825164399 3901 17057871
SGTC_3058 9093861 49.47 µM -0.885318606486381 0.158383392290948 no 2827 0.18799240873132 3952 17217477
SGTC_2351 9026858 72.31 µM -0.886823469368243 0.157992184710389 no 2828 0.1875869749459 3874 1409300
SGTC_2205 7238770 200 µM -0.88719711920082 0.157895148247218 no 2829 0.187486391577819 4012 279867
SGTC_3212 9128307 49.47 µM -0.887417064598048 0.157838046964548 no 2830 0.187427199728627 3920 27243542
SGTC_2804 7954240 19.48 µM -0.888369347733859 0.157590975780909 no 2831 0.18717105396076 4002 828705
SGTC_2407 paclitaxel 400 µM -0.891775120550661 0.156709423968365 no 2832 0.18625673979967 4127 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_993 3909-8757 62.7 µM -0.894679835149806 0.155960135792908 no 2833 0.185479130547148 3931 4288324 YLR208W SEC13
SGTC_2278 7948257 134.34 µM -0.899604099192034 0.154695296710488 no 2834 0.184165487479144 3967 1247028
SGTC_1508 1080-0625 72.9 µM -0.899913744998376 0.154615988698597 no 2835 0.184083077421261 3856 767111
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.900411224963468 0.154488627948443 no 2836 0.183950724698648 4003 65057 A dermal irritant. YDR527W RBA50
SGTC_953 1188-0045 9.7 µM -0.900727829839104 0.154407609480355 no 2837 0.183866523995134 4016 6144426
SGTC_645 0845-0943 5.41 µM -0.90092013142532 0.1543584136565 no 2838 0.183815393328569 3974 1885106
SGTC_2092 5303694 80.6725 µM -0.903078759095818 0.153806890871201 no 2839 0.183242048178213 3972 1963699
SGTC_296 1222-0039 74.9 µM -0.903406083807727 0.153723374434765 no 2840 0.183155206149087 3969 5984176
SGTC_1195 1502-0147 41.1 µM -0.904953909133001 0.153328855698427 no 2841 0.182744902733351 3957 817940
SGTC_1917 st066507 28.5 µM -0.905794713011535 0.153114828120303 no 2842 0.182522259960318 3949 3156428
SGTC_2969 9091408 28.7 µM -0.907296052908433 0.152733153032756 no 2843 0.182125130455007 3935 4286311
SGTC_3349 9149703 23.001 µM -0.911336679667236 0.151709070060721 no 2844 0.181059002831685 3980 4910494
SGTC_1211 1056-0033 32.3 µM -0.912346178463862 0.151453930190289 no 2845 0.180793256208752 4033 6741922
SGTC_725 1497-0963 19 µM -0.916100498393793 0.150507571374564 no 2846 0.179807093212679 4075 3549977
SGTC_2046 4110841 106 µM -0.917674137614003 0.15011207510692 no 2847 0.179394745702952 3998 44119630 YMR134W ERG29
SGTC_1617 st002906 78 µM -0.919977582181366 0.149534410208485 no 2848 0.178792237143688 3991 5150859
SGTC_1740 st038286 13.222 µM -0.922812851211452 0.148825412211296 no 2849 0.17805237124546 4056 716786
SGTC_1016 4226-1401 38 µM -0.923093872613828 0.148755261515593 no 2850 0.17797914375936 3969 2901613
SGTC_1000 4048-0884 8.67 µM -0.925227480292243 0.148223375115963 no 2851 0.177423795987853 4050 13040088
SGTC_1602 st001878 87.6 µM -0.927913482739895 0.147555593684129 no 2852 0.176726224999449 4014 595405 YLR310C CDC25
SGTC_2735 sertaconazole 140 nM -0.928434148637141 0.147426381716971 no 2853 0.176591205836905 4113 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3150 9097574 49.47 µM -0.928495647866895 0.147411124660585 no 2854 0.176575262155772 4038 17217476
SGTC_2732 terfenadine 20 µM -0.928761215339632 0.147345253417091 no 2855 0.176506424217082 4016 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1773 st048542 73.5835 µM -0.930115635577521 0.147009610481403 no 2856 0.176155608053401 3950 3237138
SGTC_975 1335-0046 28.5 µM -0.931691138642731 0.14661982591421 no 2857 0.175748083656057 4013 16486740
SGTC_1256 0570-0116 285 µM -0.936616960947946 0.145405638879933 no 2858 0.17447781213989 4036 410638
SGTC_716 1683-5115 658 µM -0.939214591160614 0.144768069304283 no 2859 0.17381028951598 3965 723597
SGTC_1005 4092-0690 4.4 µM -0.939305263539768 0.144745848481463 no 2860 0.173787018476605 4049 1529343
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.93993236979886 0.144592228212404 no 2861 0.17362612609519 4083 165506
SGTC_758 0868-0029 16 µM -0.941557855730715 0.144194549460371 no 2862 0.173209527625458 4068 762687
SGTC_340 k038-0059 454 µM -0.941813694823085 0.144132025084308 no 2863 0.173144016229065 3999 23733424
SGTC_439 amiodarone 34.4 µM -0.942184286105622 0.144041488905329 no 2864 0.173049148821377 3878 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3063 1327-0034 4 µM -0.943548250074263 0.143708600216434 no 2865 0.1727002738951 3930 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2309 7664088 163.95 µM -0.944574427438796 0.143458494113293 no 2866 0.172438093856745 4044 704922
SGTC_3040 9091894 49.47 µM -0.948399575482196 0.142528796506025 no 2867 0.171463037734133 3902 25236966
SGTC_2619 obliquin 87.91 µM -0.948568355597783 0.142487868779664 no 2868 0.171420095864728 3966 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2475 5812728 15.03 µM -0.948878262184883 0.142412739797006 no 2869 0.171341265802212 3985 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_683 panaxydol 45 µM -0.952213586119206 0.14160587131287 no 2870 0.170494336069946 4019 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1248 0469-0687 58.6 µM -0.952656413683694 0.141498977560448 no 2871 0.170382091999484 4041 4017482
SGTC_3182 9108849 49.47 µM -0.95471086294815 0.141003771258054 no 2872 0.169861967448994 4076 17133045
SGTC_2460 5552655 174.22 µM -0.956145513441058 0.140658659634096 no 2873 0.16949936157875 4066 5401989
SGTC_14 0354-0009 295 µM -0.958973124294029 0.139980144713343 no 2874 0.168786142292798 4110 1713507
SGTC_306 1672-3436 11.6 µM -0.960889757155863 0.139521495305137 no 2875 0.168303800740902 4094 6797378
SGTC_338 4055-0136 114 µM -0.962337686784065 0.139175684828857 no 2876 0.167940001944551 3983 2900563
SGTC_2383 9036125 200 µM -0.962560722349726 0.139122468913863 no 2877 0.167884008284163 3967 79580
SGTC_205 1486-1330 71.903 µM -0.963716355571386 0.138846958550128 no 2878 0.167594076039456 4063 4118834
SGTC_1665 st014639 11.4 µM -0.964340034989534 0.138698423851779 no 2879 0.167437737658256 4095 981133 YIL048W NEO1
SGTC_969 1313-0238 134 µM -0.967858012465095 0.137862614309429 no 2880 0.166557643153696 4075 5212874
SGTC_266 formosanin C 406 nM -0.968755219853371 0.137650004688604 no 2881 0.166333666986291 3948 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2207 7258803 200 µM -0.969123744485813 0.13756274093917 no 2882 0.166241725977651 4011 3666799
SGTC_2063 5246145 200 µM -0.969451273018867 0.137485216446986 no 2883 0.166160040396227 4088 711240
SGTC_794 k038-0031 316 µM -0.970036373986945 0.137346799995547 no 2884 0.166014180820078 4044 6624242
SGTC_3072 9116419 49.47 µM -0.971342923251188 0.137038055217869 no 2885 0.165688770451947 4098 17170162
SGTC_1050 3232-1156 69.3 µM -0.975283351514817 0.136109783665006 no 2886 0.164709863206597 4039 700529
SGTC_1441 4106-0040 13 µM -0.978361133684988 0.135387731340958 no 2887 0.163947871902358 4045 2904180
SGTC_2461 5755302 26.15 µM -0.978972560363566 0.135244602868229 no 2888 0.163796768843783 4116 2788904
SGTC_582 0987-0078 156 µM -0.980789617085898 0.134819861603128 no 2889 0.163348249741187 4101 1625765
SGTC_3331 9141060 1.957 µM -0.981324367684569 0.134695036885795 no 2890 0.16321640493467 4023 4906567 YPR165W RHO1
SGTC_2770 toltrazuril 17.5 µM -0.982506932133621 0.134419277237329 no 2891 0.162925084761382 3959 68591 Kills coccidiodes.
SGTC_307 1501-1223 22.3 µM -0.982946715135933 0.134316824139771 no 2892 0.162816832214945 4099 2830329
SGTC_663 1486-0733 13.9 µM -0.983782558377653 0.134122251568624 no 2893 0.16261121843652 4093 722445 YPR165W RHO1
SGTC_2036 5160441 105 µM -0.984074568774022 0.134054321310764 no 2894 0.162539424992483 4044 134534 YIL048W NEO1
SGTC_2390 9097792 176.6 µM -0.984744507216368 0.133898563146126 no 2895 0.162374792408368 4070 4497149
SGTC_852 0418-0143 439 µM -0.984834680440849 0.133877607712131 no 2896 0.162352641273481 4087 5369229
SGTC_1703 st026983 48.3 µM -0.986128709547904 0.133577135416969 no 2897 0.162034978503645 4096 1104023
SGTC_2147 5545932 89.7195 µM -0.986731526588138 0.133437320343532 no 2898 0.161887135191341 4087 797404
SGTC_2652 actinonin 100 µM -0.987317637846614 0.133301476492904 no 2899 0.161743473332474 4075 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2423 st077119 87.2 µM -0.988114213743433 0.133117005528203 no 2900 0.16154835767386 4002 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1452 4194-0072 190 µM -0.995644778019553 0.131381759161316 no 2901 0.159711384987577 4155 1343545
SGTC_2023 5144124 124 µM -0.996263811441667 0.131239814952858 no 2902 0.159560991027293 4064 2830192
SGTC_2785 7756463 72.73 µM -0.996936452896627 0.1310856985422 no 2903 0.159397678128325 4042 2201551
SGTC_3252 9135871 49.47 µM -0.998473432735901 0.130734013260735 no 2904 0.159024920463478 4119 17682838
SGTC_160 3453-0671 289.699 µM -1.00122609638568 0.130105791566618 no 2905 0.158358756379428 4136 5322268
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.00166532602472 0.130005742779484 no 2906 0.158252629316547 4131 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3002 9075603 71.4286 µM -1.00533388131937 0.129172190210426 no 2907 0.15736805285644 4030 20105405
SGTC_1027 k015-0025 8.67 µM -1.00750757790525 0.128680044396892 no 2908 0.156845458988185 4058 3598955
SGTC_1978 st071761 42 µM -1.00808667153832 0.128549151793633 no 2909 0.156706427822112 4114 5147680
SGTC_1515 3460-0031 42.1 µM -1.01020068920872 0.128072104656448 no 2910 0.156199574573336 4034 2876596
SGTC_2007 4011539 71.82 µM -1.01461343781463 0.127080294344708 no 2911 0.155145065613269 4067 45595301
SGTC_1935 st074532 41.6 µM -1.01479104148302 0.127040488306561 no 2912 0.155102722506701 4098 2829742
SGTC_1785 bathophenanthroline 24 µM -1.0148979735915 0.127016525962394 no 2913 0.155077232132145 4025 72812 An iron chelator.
SGTC_1220 1838-0075 193 µM -1.01594074643138 0.12678301660069 no 2914 0.154828801945701 4010 5529645
SGTC_921 1561-0023 372 µM -1.01662151501153 0.126630732642692 no 2915 0.154666757569657 4075 24050882
SGTC_1249 0481-0015 10.2 µM -1.01839982052325 0.12623353726046 no 2916 0.154243993730987 4049 4227577
SGTC_2805 7950783 58.44 µM -1.01842035269518 0.12622895635097 no 2917 0.154239117000892 4140 1178958 YDL195W SEC31
SGTC_493 zm226600 134 µM -1.01856161149146 0.126197443402445 no 2918 0.154205568466802 4155 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1820 st053765 18.6 µM -1.0203697671755 0.125794552330803 no 2919 0.153776563296022 4171 3690829
SGTC_3026 9090633 49.47 µM -1.02169581722679 0.125499654285737 no 2920 0.153462445706526 4113 25236842
SGTC_814 3342-0569 96 µM -1.02397665994586 0.124993550817702 no 2921 0.152923149613057 4177 4346283
SGTC_2809 7964133 12.99 µM -1.0247019680218 0.124832909074206 no 2922 0.152751917084362 4127 1253665
SGTC_752 1896-0090 130 µM -1.02671657552405 0.124387469403265 no 2923 0.15227697095395 4105 772567
SGTC_1864 st057645 30.4 µM -1.02962689128913 0.123745948776598 no 2924 0.151592593365721 4154 688666
SGTC_2728 chlorpromazine 9.18 µM -1.02994144423352 0.123676750863516 no 2925 0.151518747047155 4155 2726 A thorazine and dopamine antagonist.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.03638993945215 0.122264126767708 no 2926 0.150010130986603 4230 688801
SGTC_3152 9099253 49.47 µM -1.03917342154648 0.121657883025335 no 2927 0.149362044562315 4062 25236131
SGTC_1573 oleylamine 1.06 µM -1.04226133846519 0.120987808510095 no 2928 0.14864526584247 4116 5356789 An amine of the fatty acid oleic acid.
SGTC_1846 st056244 14.8 µM -1.04260138830632 0.120914177110877 no 2929 0.148566473005451 4159 5393182
SGTC_1188 1403-0014 4.57 µM -1.04329584618966 0.12076390328395 no 2930 0.148405647159611 4122 9614867
SGTC_1834 st055981 52.8 µM -1.04637367752313 0.120099473539732 no 2931 0.147694270408403 4159 471719 YDL150W RPC53
SGTC_2124 5246320 200 µM -1.04673955212014 0.12002066167277 no 2932 0.147609858225624 4156 579342
SGTC_641 4092-0595 30 µM -1.04970907081963 0.119382355609518 no 2933 0.146925946013781 4173 786260
SGTC_1929 genistein trimethyl ether 50.5 µM -1.05233314824349 0.118820299923225 no 2934 0.146323364188251 4140 136420
SGTC_2263 7948595 193.29 µM -1.05233946393489 0.118818949412899 no 2935 0.146321915884781 4126 2971371
SGTC_1096 rimcazole 32.2 µM -1.0540557521477 0.118452350162104 no 2936 0.145928696337039 4066 18528119 A dopamine reuptake inhibitor.
SGTC_513 4245-1575 41.7 µM -1.05409243309576 0.118444523845138 no 2937 0.145920300106462 4038 719745
SGTC_2418 pentamidine 31.67 µM -1.05489188127248 0.118274042840909 no 2938 0.145737387893791 4107 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.05564513654191 0.118113571209627 no 2939 0.145565185614173 4119 688803
SGTC_2226 7298446 200 µM -1.05712247185509 0.117799290655808 no 2940 0.145227848291787 4136 3283010
SGTC_2150 5556613 200 µM -1.05970012017287 0.117252353200014 no 2941 0.144640524059706 4150 743190
SGTC_2974 9094440 9.66 µM -1.06237365542011 0.116686972904954 no 2942 0.144033044332463 4174 25236134
SGTC_613 3914-0030 117 µM -1.06342936555558 0.116464252009287 no 2943 0.143793640788634 3871 1145395
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.06361815370237 0.116424455584243 no 2944 0.143750857586874 4143 676296 Flavone; oxidizing agent.
SGTC_2514 salinomycin 42.74 µM -1.06400068545548 0.116343847704464 no 2945 0.143664194512542 4203 23682228 A polyether potassium ionophore.
SGTC_1064 honokiol 6.76 µM -1.06427603153542 0.116285850724002 no 2946 0.143601836322266 4163 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1484 3473-2379 286 µM -1.06514697352561 0.11610253664442 no 2947 0.14340471260216 4278 671917
SGTC_2110 5483698 200 µM -1.06673518068248 0.115768782307687 no 2948 0.143045717991634 4130 2848765 YHR062C RPP1
SGTC_782 0083-0095 30.5 µM -1.06708107097947 0.115696185520931 no 2949 0.142967614352072 4143 3591729 An indicator and reagent.
SGTC_600 1495-0418 41.6 µM -1.0702858006691 0.115025101926752 no 2950 0.142245341910813 4150 5377768
SGTC_168 3970-0862 530.542 µM -1.07396756153812 0.114257548470643 no 2951 0.141418610262048 4133 3135186
SGTC_1202 1988-0068 29.6 µM -1.07671345781759 0.113687478339862 no 2952 0.1408041491002 4141 2850480
SGTC_1165 k072-0275 30.3 µM -1.07788314316198 0.113445259067368 no 2953 0.140542954501857 4150 6153523 YGL055W OLE1
SGTC_2210 7115885 190.385 µM -1.07877531647207 0.113260754758501 no 2954 0.140343950503695 4241 2927039
SGTC_2358 9037157 4 µM -1.0794996924371 0.113111109017877 no 2955 0.140182515414086 4173 2388925
SGTC_2935 9038016 29.96 µM -1.08602332578008 0.111769773488669 no 2956 0.138734336259914 4160 6463195
SGTC_1438 4092-1045 4 µM -1.08676102995112 0.111618811904642 no 2957 0.138571217197111 4189 1351342
SGTC_1633 st005664 67.9 µM -1.08692286466103 0.111585714052339 no 2958 0.138535450247816 4172 2063822
SGTC_2926 9010726 65.15 µM -1.08717452857612 0.111534258606033 no 2959 0.138479842721362 4217 2994293
SGTC_1292 0kpi-0043 232 µM -1.08859370560988 0.111244410129745 no 2960 0.138166546860959 4202 3333905
SGTC_2065 5221596 34.26 µM -1.09043890013952 0.110868360051847 no 2961 0.137759927062289 4171 788581
SGTC_2149 5554786 194.827 µM -1.09254409987017 0.110440434252331 no 2962 0.137297008901282 4201 745063 YPR165W RHO1
SGTC_1122 capsaicin 818.572 nM -1.09330414222304 0.110286231091104 no 2963 0.137130142405964 4241 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_299 1273-0059 1.44 µM -1.09416486380295 0.110111787877899 no 2964 0.136941339248926 4025 2848077
SGTC_947 3447-0010 211 µM -1.09425835230525 0.11009285240342 no 2965 0.136920842825499 4146 748350
SGTC_1402 3909-7673 35.9 µM -1.09583918765956 0.109773018371936 no 2966 0.136574577861195 4193 5328014
SGTC_2495 cafestol 54.53 µM -1.09675308852725 0.109588422801176 no 2967 0.136374671119087 4194 16667697 An anti-infammatory.
SGTC_596 1155-0152 116 µM -1.0975067330192 0.109436364617434 no 2968 0.136209969542143 4188 280313
SGTC_2231 micatex 6.853 µM -1.09825721305073 0.109285095549822 no 2969 0.136046094843671 4208 20737 An antifungal of unknown mechanism.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.09943308651409 0.109048385038372 no 2970 0.135789602793504 4227 6708561
SGTC_1487 3970-0795 2.82 µM -1.10046754788685 0.108840446525151 no 2971 0.135564230813076 4222 3765103
SGTC_2892 9047358 58.44 µM -1.10117115544272 0.108699176386997 no 2972 0.135411086515193 4198 6466771
SGTC_2682 pyrogallin 40.03 µM -1.10123257951062 0.108686849940285 no 2973 0.135397722837135 4191 822798 An ATP competetive kinase inhibitor.
SGTC_3157 9099274 49.47 µM -1.10319612321677 0.108293339886636 no 2974 0.134971002267129 4228 17217662
SGTC_375 3970-0961 9.27 µM -1.10347600991454 0.108237331927526 no 2975 0.134910252023045 4144 2898222
SGTC_1232 0279-0259 161 µM -1.10572183191623 0.107788676537009 no 2976 0.134423468746865 4202 1560000
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.10677677988367 0.107578389090563 no 2977 0.134195224928014 4207 16486 A toxic proline analog.
SGTC_1720 st037298 9.481 µM -1.1089607015506 0.10714399812892 no 2978 0.133723567748036 4197 597396
SGTC_1895 st058434 18.3 µM -1.11132937943838 0.106674289906328 no 2979 0.133213298899468 4224 5393175
SGTC_2366 9070441 60.58 µM -1.11134090324233 0.106672008377472 no 2980 0.133210819681009 4186 6837235
SGTC_2441 5730946 39.09 µM -1.11583384763646 0.10578515900329 no 2981 0.132246631214443 4256 1774275
SGTC_827 3253-0474 693 µM -1.11610253529217 0.105732292920733 no 2982 0.132189123532428 4240 5402065
SGTC_3276 9139060 49.47 µM -1.11782100868606 0.105394623541565 no 2983 0.131821723481567 4295 4870619
SGTC_3014 9081533 49.47 µM -1.1179051408225 0.105378112150722 no 2984 0.131803754605467 4253 21367265
SGTC_2332 7982454 138.89 µM -1.11930062591416 0.105104513462437 no 2985 0.131505954447227 4148 2981748
SGTC_3336 9143619 71.43 µM -1.12004150576816 0.104959465722247 no 2986 0.131348037649676 4250 45595730
SGTC_1367 1812-0510 76.9 µM -1.12286178743744 0.104408643274335 no 2987 0.130748099422015 4245 1142582 YDR527W RBA50
SGTC_1879 gemcitabine 100 µM -1.12333259305486 0.104316895754928 no 2988 0.130648133122253 4190 60750 A nucleoside analog which inhibits DNA replication.
SGTC_833 3852-0053 558 µM -1.12337888214584 0.104307878395376 no 2989 0.130638307399403 4284 3123681
SGTC_2489 cantharidin 73.42 µM -1.12482724100967 0.104026015750476 no 2990 0.13033112428928 4172 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2129 girgensonine 121.053 µM -1.12977974508592 0.103066390953394 no 2991 0.129284522542984 4231 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1013 4112-3890 241 µM -1.13054506458981 0.102918673811792 no 2992 0.129123310370051 4156 705171
SGTC_1164 k060-0068 93.7 µM -1.13183214417104 0.102670596786159 no 2993 0.128852505453341 4222 5963676
SGTC_2965 9082772 38.63 µM -1.13556625398981 0.101953329249352 no 2994 0.128069069409482 4246 16459634
SGTC_3088 9117578 49.47 µM -1.13929397288474 0.10124093355396 no 2995 0.127290280701111 4279 678341
SGTC_2151 5563267 85.4165 µM -1.14047976972933 0.101015080870641 no 2996 0.127043238120005 4279 5310824
SGTC_2238 6671620 73.2395 µM -1.1435754512943 0.100427193592645 no 2997 0.126399873623375 4149 729941
SGTC_2620 irigenin 100 µM -1.14623280885184 0.0999245411353054 no 2998 0.125849418004459 4269 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_820 1582-0060 59.9 µM -1.15245752048387 0.0987543038788286 no 2999 0.124566558019943 4256 3848840
SGTC_121 0557-0495 61.343 µM -1.1540531188186 0.0984559550194258 no 3000 0.124239195997096 4323 3104427
SGTC_2401 5128683 200 µM -1.15601270306124 0.0980904508358775 no 3001 0.123837980526482 4267 708373
SGTC_2751 anetholtrithion 17.25 µM -1.15738305488905 0.0978354423923564 no 3002 0.123557947010458 4236 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3160 9100216 49.47 µM -1.16603710151585 0.0962362299441345 no 3003 0.121799722613555 4219 17191039
SGTC_1051 3253-3903 78 µM -1.16686642857203 0.0960839904437519 no 3004 0.121632157634065 4242 5509239
SGTC_2611 pyromycin 23.93 µM -1.16853890436733 0.0957775129522466 no 3005 0.121294727975253 4223 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_218 alverine citrate 93.75 µM -1.17519570587843 0.0945647953305186 no 3006 0.119958213909059 4307 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1470 k295-0292 231 µM -1.1755683948619 0.0944972360384969 no 3007 0.119883695646216 4335 5045612
SGTC_787 4152-0075 138 µM -1.1781576019769 0.094028858997665 no 3008 0.119366890820331 4276 9566539
SGTC_2529 gangaleoidin 93.61 µM -1.1796975560006 0.0937511011948701 no 3009 0.119060263145106 4280 4565183
SGTC_1802 st050112 57.9 µM -1.18040006685386 0.0936245923796826 no 3010 0.118920567690799 4266 4662563
SGTC_1511 0906-3109 28.5 µM -1.18158119134642 0.0934121785715092 no 3011 0.118685960102778 4272 2882180
SGTC_2212 7123476 200 µM -1.18392133398456 0.0929923782992877 no 3012 0.118222102114278 4264 1085715
SGTC_901 1112-0062 60.1 µM -1.18541281088961 0.092725549583103 no 3013 0.117927134494343 4276 1908457
SGTC_228 caffeine 993.056 µM -1.18853516365549 0.0921687875672048 no 3014 0.117311317336421 4280 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2521 angolensin 13.4 µM -1.1888919484878 0.0921053254017756 no 3015 0.117241094441295 4320 821428 A flavenoid.
SGTC_668 1682-0499 62.6 µM -1.19363858437123 0.0912641059224785 no 3016 0.11630968701499 4245 682214
SGTC_621 3584-0052 32.1 µM -1.19403395124583 0.0911942951315828 no 3017 0.116232343782379 4301 2273927
SGTC_1365 1672-3266 55.4 µM -1.19631327828123 0.0907926014266542 no 3018 0.11578716449532 4299 6415873
SGTC_2388 9080168 200 µM -1.19899116383578 0.0903223475577291 no 3019 0.11526569073093 4295 15943073
SGTC_2235 salicylic acid 500 µM -1.19934877185449 0.090259686454346 no 3020 0.115196179062472 4313 338 A COX inhibitor and kinase inhibitor.
SGTC_1290 0986-0249 10.2 µM -1.20636638402071 0.0890365658364317 no 3021 0.113838125839896 4143 53329
SGTC_2236 dapsone 200 µM -1.20656923992238 0.0890013938476628 no 3022 0.113799039421152 4277 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3289 9119912 71.43 µM -1.20693590273024 0.0889378465879019 no 3023 0.113728414841954 4317 17014829
SGTC_2055 5235184 200 µM -1.20768953473714 0.0888073387881646 no 3024 0.113583352488823 4335 2836034
SGTC_2186 6124449 200 µM -1.21015899456579 0.0883806972024438 no 3025 0.113108944656228 4293 3834182 YLR033W RSC58
SGTC_605 1315-0399 119 µM -1.21050436130077 0.0883211511138329 no 3026 0.113042709132172 4361 24020461
SGTC_2629 bisabolol 100 µM -1.22264066293652 0.0862476208658681 no 3027 0.110732723809741 4336 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1889 st059080 5.18 µM -1.22379994332297 0.0860514749008675 no 3028 0.110513852862377 4268 176925 Isolated from Daphnopsis sellowiana.
SGTC_1148 3909-7663 27.7 µM -1.22403515294429 0.0860117190597683 no 3029 0.110469483397368 4358 4084526
SGTC_1613 st002381 52.1 µM -1.22438946382969 0.0859518583087706 no 3030 0.110402671022463 4292 551167
SGTC_1372 2752-0194 270 µM -1.22815412813664 0.0853177433247838 no 3031 0.109694557459699 4246 823334
SGTC_2731 amoxapine 43.43 µM -1.22974242147786 0.0850512670145544 no 3032 0.109396787888077 4461 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_757 1066-0008 322 µM -1.23023819411537 0.0849682165146991 no 3033 0.109303960583866 4346 6842497
SGTC_3129 9127257 49.47 µM -1.23303532171313 0.0845007878971496 no 3034 0.108781293142077 4267 837894
SGTC_926 2268-1401 59.4 µM -1.23368296923919 0.0843928349329373 no 3035 0.10866053125974 4285 2931578
SGTC_903 1134-0042 114 µM -1.23650775103691 0.0839231966510638 no 3036 0.108134943190272 4320 701009
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.23672670090566 0.0838868769377522 no 3037 0.108094281223431 4316 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_549 1661-1316 519 µM -1.23808032295561 0.0836625982399547 no 3038 0.107843139589085 4349 2857282
SGTC_2791 5663188 71.43 µM -1.24118043842958 0.0831506446213946 no 3039 0.10726954974659 4346 54690634
SGTC_2291 7917025 104.35 µM -1.24137792372612 0.0831181118543641 no 3040 0.107233085267953 4214 2964612
SGTC_2499 avocadenofuran 51.48 µM -1.24209081749266 0.0830007528441857 no 3041 0.107101528063884 4276 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1186 1319-0216 26 µM -1.24536650392645 0.0824630998221214 no 3042 0.106498530024812 4403 4565136
SGTC_1527 coumarin 137 µM -1.24651261154523 0.082275604574783 no 3043 0.106288131050205 4381 323 A hepatotoxic, DNA x-linker.
SGTC_112 phenothiazine 287.218 µM -1.24869650999647 0.0819192229741801 no 3044 0.105888048922035 4282 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_210 3551-0445 56.827 µM -1.25037999448736 0.0816452968554244 no 3045 0.105580384503947 4354 2865180 YOR207C RET1
SGTC_1335 1486-0900 202 µM -1.25225869781856 0.0813404219211733 no 3046 0.105237806768285 4317 X1335
SGTC_2004 4023728 41.89 µM -1.25248415371993 0.0813038928514606 no 3047 0.105196749455868 4310 360084 YDR527W RBA50
SGTC_630 4356-0227 183 µM -1.254420117238 0.080990731219986 no 3048 0.104844672121383 4281 779312
SGTC_1072 oxiconazole 14.9 nM -1.25742364601433 0.0805066833227535 no 3049 0.104300135643977 4309 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_931 2812-0076 566 µM -1.26020716645265 0.0800600460351264 no 3050 0.103797319144026 4270 3450959
SGTC_1711 st032263 62.8 µM -1.26081014559412 0.0799635407134613 no 3051 0.10368862879067 4327 3958979
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.26699004527248 0.0789795279782675 no 3052 0.102579424691959 4296 2333 A French combination drug.
SGTC_1968 st069590 43.6 µM -1.26812495431355 0.0787998198488482 no 3053 0.102376665652068 4295 6384066
SGTC_836 0330-0104 1.35 µM -1.26901416829533 0.0786592331121472 no 3054 0.102218005417406 4364 46494820
SGTC_772 k072-0172 35.3 µM -1.27616322696459 0.0775358502941829 no 3055 0.100948912403921 4400 5861980
SGTC_323 4013-0906 34.3 µM -1.27622041425768 0.077526913420923 no 3056 0.100938807100167 4365 2910086
SGTC_2985 9022375 71.43 µM -1.27703590494053 0.0773995587175212 no 3057 0.100794785721397 4399 4939335
SGTC_1944 st076371 56.9 µM -1.27878356460653 0.0771271629680287 no 3058 0.100486641556776 4312 24208455
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.27980711529757 0.0769679677324319 no 3059 0.100306490420925 4339 229346 A bile salt which induces apoptosis.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.28474960251359 0.0762027640917512 no 3060 0.0994398993582462 4409 279621
SGTC_49 0717-0965 32.132 µM -1.28533395847296 0.0761126772920808 no 3061 0.0993378041692173 4421 5889349 YGL099W LSG1
SGTC_1270 0831-1170 17.3 µM -1.2867004054433 0.0759023364770354 no 3062 0.0990993658590695 4354 6764716
SGTC_2881 9058953 51.95 µM -1.28686526721515 0.0758769888201479 no 3063 0.0990706266083281 4299 17122249
SGTC_2012 4023501 200 µM -1.28697627437523 0.075859924993841 no 3064 0.099051278906644 4351 3477460
SGTC_3266 9136860 49.47 µM -1.29098037076765 0.0752463742941533 no 3065 0.0983552420841459 4146 4871271 YPR165W RHO1
SGTC_1961 st076550 68.7 µM -1.29408690041132 0.0747729702359574 no 3066 0.0978177029049783 4381 1579337
SGTC_541 4513-1321 94 µM -1.29420114664691 0.0747556036753534 no 3067 0.0977979754134742 4326 747515
SGTC_2938 9059746 27.26 µM -1.29595444368472 0.0744894710360793 no 3068 0.0974955902375308 4367 6471769
SGTC_1081 sertraline 6 µM -1.2974040134715 0.0742699877818336 no 3069 0.0972461061568781 4340 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3025 9087895 49.47 µM -1.29930548185102 0.0739828305976929 no 3070 0.0969195569189257 4331 17173641
SGTC_1460 k062-0059 9.15 µM -1.30354329745987 0.0733458944005589 no 3071 0.0961946723015265 4257 1373085
SGTC_2902 5787006 60.46 µM -1.30669125457359 0.0728754834005747 no 3072 0.0956587950153131 4324 591003
SGTC_2365 9042475 200 µM -1.30878406142912 0.0725640278948814 no 3073 0.0953037537076419 4406 6464479
SGTC_3293 9120939 62.045 µM -1.31354802882278 0.0718588481890785 no 3074 0.094499174003799 4360 934087
SGTC_3209 9113616 49.47 µM -1.31388074530525 0.0718097953208238 no 3075 0.0944431696492178 4417 16649353
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.31923910473949 0.0710233375836277 no 3076 0.093544594395523 4442 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3230 9131665 49.47 µM -1.31930737504479 0.0710133602577731 no 3077 0.093533186617225 4370 15943720
SGTC_1801 st050089 28.441 µM -1.31940187069941 0.0709995520190378 no 3078 0.0935173983512031 4414 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_417 st075190 100 µM -1.31966902656113 0.07096052485218 no 3079 0.0934727727903241 4365 222757
SGTC_1903 st060211 78.3 µM -1.31976445520514 0.0709465882597589 no 3080 0.0934568362578417 4398 688960
SGTC_853 0419-0306 21 µM -1.32202832089256 0.0706165849358787 no 3081 0.0930793602149739 4400 762713
SGTC_831 k061-1017 217 µM -1.32257764610437 0.0705366880321965 no 3082 0.0929879360780717 4411 1240153
SGTC_618 k072-0232 33.2 µM -1.32349130231607 0.0704039547290484 no 3083 0.092836023418499 4426 5872756 YGL099W LSG1
SGTC_743 1275-0778 158 µM -1.32607882628471 0.0700290888248055 no 3084 0.0924067943889384 4370 2849257 YMR203W TOM40
SGTC_2239 6685329 187.64 µM -1.32968720197609 0.069508893971589 no 3085 0.0918106766271985 4414 805680
SGTC_635 k038-0028 24.7 µM -1.33002413919184 0.0694604723394908 no 3086 0.0917551590305232 4370 4035102
SGTC_3290 9121031 71.43 µM -1.3356545380973 0.0686551600898699 no 3087 0.090831107616235 4394 17014854
SGTC_1565 sinapyl alcohol 95.1 µM -1.34029590816603 0.0679967383514822 no 3088 0.0900745806321268 4397 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1291 0993-0025 5.79 µM -1.34369302228557 0.067517923974578 no 3089 0.0895238373205553 4377 4353356
SGTC_830 4076-0286 57.8 µM -1.34870182315592 0.0668167047876502 no 3090 0.0887163798516753 4458 6866659
SGTC_1308 1187-1617 41.4 µM -1.35101238931083 0.0664951366671458 no 3091 0.0883457320062076 4431 2882570
SGTC_1311 1190-0148 100 µM -1.35381030647863 0.066107347800892 no 3092 0.0878984523352975 4443 1961333
SGTC_581 0958-0271 211 µM -1.35591535095644 0.0658167471379105 no 3093 0.0875630513274626 4415 4591145
SGTC_867 0518-0118 155 µM -1.3561711994906 0.0657814949237165 no 3094 0.0875223516408326 4402 6848158
SGTC_2617 dihydrotanshinone i 20.83 µM -1.3608722836612 0.0651363556501053 no 3095 0.0867770268978948 4368 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2258 7960471 200 µM -1.36525602395892 0.0645392001773544 no 3096 0.0860862977344178 4416 2974708
SGTC_1287 0971-0001 34.6 µM -1.36903973485028 0.0640272081586784 no 3097 0.0854934273213059 4392 4665869
SGTC_3258 9138477 49.47 µM -1.37430937048822 0.0633194173340225 no 3098 0.0846728292351707 4452 4970355
SGTC_1775 st081588 35.1725 µM -1.38127621993563 0.06239303322408 no 3099 0.0835970235056424 4418 1426443 YGL099W LSG1
SGTC_1289 0976-0073 69.1 µM -1.3830075775191 0.0621644616922919 no 3100 0.0833312712310127 4481 3391136
SGTC_463 ikarugamyin 104 µM -1.38326057920681 0.0621311155162589 no 3101 0.0832924903375292 4570 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1877 wortmannin 25 µM -1.38551576797086 0.0618344929659202 no 3102 0.082947407219106 4445 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3238 9133470 49.47 µM -1.38668457344438 0.0616811967411416 no 3103 0.0827689833117399 4437 3534688
SGTC_255 tunicamycin 200.472 nM -1.38743364781574 0.0615831070312394 no 3104 0.0826547853700885 4349 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1415 3966-0071 78.1 µM -1.39026307097245 0.061213698717278 no 3105 0.0822245037037406 4330 2893185
SGTC_207 4185-0010 4.486 µM -1.39622762398955 0.0604406433389121 no 3106 0.0813229803387805 4506 3761753
SGTC_759 3486-0358 89.3 µM -1.39646214350568 0.0604104044827108 no 3107 0.0812876864170339 4424 875103
SGTC_3282 9108498 15.4605 µM -1.39707174849106 0.0603318576322923 no 3108 0.0811959982149472 4392 16459645
SGTC_2486 5283202 22.39 µM -1.39903609442853 0.060079297749431 no 3109 0.0809010797732598 4448 1377751
SGTC_1282 0886-0010 32.4 µM -1.40270324259752 0.0596100212464418 no 3110 0.080352674992499 4464 2836211 YNL267W PIK1
SGTC_2424 5537928 59.2 µM -1.40307717938425 0.0595623312522665 no 3111 0.0802969127064244 4442 5382802
SGTC_2312 7706453 155.7 µM -1.40625135834608 0.0591587159294629 no 3112 0.0798247492156457 4436 976098
SGTC_1259 0671-0132 43 µM -1.40652410519985 0.0591241349007633 no 3113 0.0797842759222933 4376 X1259
SGTC_2565 isoliquiritigenin 100 µM -1.40962266202036 0.0587323873557684 no 3114 0.0793255658895921 4462 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_904 1141-0088 396 µM -1.41048043270446 0.058624301075148 no 3115 0.0791989351093809 4441 1378119
SGTC_2523 spermine 47.74 µM -1.41153430506987 0.058491718197929 no 3116 0.0790435638862482 4458 1103 A DNA binding polyamine.
SGTC_2608 thymoquinone 42.66 µM -1.41378881741413 0.0582088789411809 no 3117 0.0787119589505712 4407 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2320 7373003 200 µM -1.41591042044807 0.0579436961836703 no 3118 0.0784008668030409 4443 5415828
SGTC_1297 1068-0111 14.1 µM -1.41990780766856 0.0574466368736503 no 3119 0.0778172613015075 4451 767057
SGTC_2069 5228469 200 µM -1.42121743942587 0.057284520858505 no 3120 0.0776267781530295 4454 2835210
SGTC_866 0495-0101 262 µM -1.42864001175425 0.0563724918675545 no 3121 0.076553863877842 4457 635694
SGTC_547 1120-0019 610 nM -1.43022572724098 0.0561791430027168 no 3122 0.0763261218782398 4424 3676939
SGTC_347 4534-1311 26.2 µM -1.4328837453969 0.055856219795441 no 3123 0.0759455316179656 4465 2862016
SGTC_2773 thioridazine 9.09 µM -1.43503545982009 0.0555958816237714 no 3124 0.0756384965990849 4435 5452 An antipsychotic.
SGTC_3269 9137823 49.47 µM -1.43563257417604 0.0555238061657139 no 3125 0.0755534602961716 4391 17682936
SGTC_1485 3909-9022 254 µM -1.43657116862808 0.0554106610386314 no 3126 0.0754199403727614 4523 714516
SGTC_2814 7977482 42.97 µM -1.4432875596106 0.0546063215052567 no 3127 0.0744697413782427 4461 6456762
SGTC_2848 9016370 25.97 µM -1.4451402115318 0.0543860844985542 no 3128 0.0742092530354109 4440 7894410
SGTC_134 0269-0018 6.916 µM -1.4476026684947 0.0540944442567076 no 3129 0.0738641022200973 4416 4378915
SGTC_1152 3909-8331 15.9 µM -1.45192176988799 0.0535859038638139 no 3130 0.0732616792986963 4443 16001939
SGTC_1873 rapamycin 2 nM -1.4524697473917 0.0535216554333599 no 3131 0.0731855175421246 4422 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2469 5655019 90.81 µM -1.45431068352544 0.0533062590051889 no 3132 0.0729300949099652 4530 2788239
SGTC_1017 4239-0030 168 µM -1.454649479045 0.0532666936204091 no 3133 0.0728831628014872 4476 1149593
SGTC_1778 st046819 58.9 µM -1.45496378738265 0.0532300087280843 no 3134 0.0728396434904051 4518 671715
SGTC_1926 methyl fluorone black 53.6 µM -1.45522475881685 0.0531995643402623 no 3135 0.0728035243564286 4103 72721 Reacts with homocysteine.
SGTC_2057 5236571 38.335 µM -1.45623700236543 0.0530816086903439 no 3136 0.0726635569201184 4416 54684039 YBR257W POP4
SGTC_1844 rapamycin 4 nM -1.4564639786934 0.0530551878684457 no 3137 0.0726322001930514 4313 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1045 1348-1485 165 µM -1.46197058540379 0.052417389677713 no 3138 0.0718746352812118 4447 6810614
SGTC_1838 st055369 84.5 µM -1.46262512655042 0.0523419844687759 no 3139 0.0717849919842792 4458 676036
SGTC_642 0335-0876 158 µM -1.46493114574782 0.0520770098130971 no 3140 0.0714698521275797 4506 6812350
SGTC_717 1532-0246 73.2 µM -1.47398871453067 0.0510465418478157 no 3141 0.0702423148802276 4451 9561992
SGTC_2362 9071156 126 µM -1.47806928323829 0.0505876345136706 no 3142 0.069694617379495 4482 653133
SGTC_2382 9035899 200 µM -1.47813690775136 0.0505800571255737 no 3143 0.0696855685299885 4481 6462679
SGTC_1032 k061-1018 98.7 µM -1.48296320307707 0.0500415971297213 no 3144 0.0690420937531403 4523 4005393
SGTC_2614 arthonioic acid 13.39 µM -1.48608705005236 0.04969551929844 no 3145 0.0686280485903491 4357 6710684
SGTC_2714 st079313 56.9 µM -1.49917529618391 0.0482662408957889 no 3146 0.0669140810066088 4482 2939799
SGTC_1867 st057372 64 µM -1.50162035404253 0.0480029142516149 no 3147 0.0665975918352291 4461 688837
SGTC_3188 9110789 49.47 µM -1.50250269106806 0.047908171566093 no 3148 0.0664836667372821 4464 849217
SGTC_2071 5230951 39.92 µM -1.5066071386383 0.0474694144833863 no 3149 0.0659556932621779 4533 1799272
SGTC_1468 k284-1086 134 µM -1.51227299709478 0.0468690415380849 no 3150 0.0652322137584074 4508 15996457
SGTC_1067 clotrimazole 1.36 µM -1.51789338375486 0.0462795193605508 no 3151 0.0645206390764018 4531 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2870 9038528 12.99 µM -1.51790405685178 0.0462784055502802 no 3152 0.0645192935578588 4528 6463316
SGTC_3317 9138495 8.753 µM -1.52283084478732 0.0457665554853407 no 3153 0.063900515461685 4424 17020139
SGTC_3171 9103192 49.47 µM -1.5284239248624 0.0451910087503128 no 3154 0.0632036592104496 4588 13018434
SGTC_1768 st044301 37.178 µM -1.53483246192073 0.0445387232079954 no 3155 0.0624124933705402 4523 3931349
SGTC_2583 asiatic acid 100 µM -1.53529632245833 0.0444918055937096 no 3156 0.0623555285395982 4515 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2960 9079389 5.97 µM -1.54679539248464 0.043341396401381 no 3157 0.0609562958063032 4485 16457355
SGTC_145 3737-0113 38.366 µM -1.5475675273134 0.0432650177748284 no 3158 0.0608632273371319 4503 6849351
SGTC_2957 9076800 11.52 µM -1.55020611868083 0.0430048315898584 no 3159 0.0605460258562945 4499 16459615
SGTC_1189 1431-2119 7.28 µM -1.55028193080283 0.0429973746333691 no 3160 0.0605369311601747 4510 3107275
SGTC_735 3076-0345 636 µM -1.55547817031756 0.0424887519264213 no 3161 0.0599161148125319 4539 2888990
SGTC_617 3770-0098 35 µM -1.56352330706994 0.0417108803990382 no 3162 0.0589647790056144 4455 5962639
SGTC_664 1222-0054 14.9 µM -1.56881474589762 0.0412055768501622 no 3163 0.058345555718471 4505 6813991
SGTC_3059 1327-0034 3 µM -1.57134309907157 0.0409658911900285 no 3164 0.0580514876117492 4388 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3166 9102297 49.47 µM -1.57517959180731 0.0406043561008333 no 3165 0.0576074982424602 4558 25237072
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.57798529176629 0.0403416015886894 no 3166 0.0572844944118048 4469 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_332 4112-0506 40.9 µM -1.57964992989803 0.0401863615653259 no 3167 0.057093529031724 4527 2790355
SGTC_1691 st019933 84.6 µM -1.58155611336139 0.0400091920032035 no 3168 0.0568754697254489 4532 6176082
SGTC_2446 5162541 200 µM -1.58747922143708 0.0394627176315445 no 3169 0.0562020746734796 4509 1549321
SGTC_2555 cholic acid 100 µM -1.59056281906657 0.0391806329694611 no 3170 0.0558539988201305 4512 6708657 Influences liver metabolism.
SGTC_1049 3226-0134 66 µM -1.59200476122889 0.0390492897391876 no 3171 0.0556918173722909 4569 5702385
SGTC_2350 9023895 38.85 µM -1.59431230287399 0.0388398470366758 no 3172 0.0554330517372949 4513 2997209
SGTC_906 1165-0455 526 µM -1.5993014557093 0.0383901365808315 no 3173 0.0548768181254831 4530 3252859
SGTC_1006 4099-6547 255 µM -1.59939012357 0.0383821828222924 no 3174 0.0548669727143042 4561 3146833
SGTC_1036 k216-0215 33.5 µM -1.60674932005212 0.0377267101453325 no 3175 0.0540546848623134 4507 622330
SGTC_512 prima-1 270 µM -1.60914984171824 0.0375148861018344 no 3176 0.0537917905035585 4551 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2269 7935389 174.42 µM -1.62010461569888 0.0365605232226507 no 3177 0.0526049030447618 4564 97605
SGTC_3257 9139206 32.98 µM -1.62087199564239 0.0364944215710431 no 3178 0.0525225469574313 4542 4910041
SGTC_342 k048-0088 23.3 µM -1.6302625992608 0.0356934134101102 no 3179 0.0515230042961339 4557 6820570
SGTC_849 0386-0493 241 µM -1.63081483287012 0.0356467606518644 no 3180 0.0514646983314906 4589 726119
SGTC_1506 4226-2149 212 µM -1.63190274789477 0.0355549996826074 no 3181 0.0513499875382713 4557 991114
SGTC_344 k064-0035 6.43 µM -1.64044272994795 0.0348413956665642 no 3182 0.050456573490703 4514 5088750
SGTC_1363 1636-0063 10.4 µM -1.64151323412801 0.0347527791071064 no 3183 0.0503454611029168 4569 6072185
SGTC_723 4182-0001 115 µM -1.64542943241728 0.0344301710214511 no 3184 0.0499406420516927 4565 744821 YLR208W SEC13
SGTC_1475 4092-1048 11.7 µM -1.66241717173731 0.0330591226107086 no 3185 0.0482145791133482 4580 2881759
SGTC_2560 caryophyllene 100 µM -1.67050459772985 0.0324223857377676 no 3186 0.0474097852634233 4601 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2567 aureobasidin a 60 nM -1.67184996169359 0.032317450977834 no 3187 0.0472769559810771 4629 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_68 0986-0284 82.829 µM -1.67242692291725 0.032272535506804 no 3188 0.0472200834158315 4531 423278 YIL048W NEO1
SGTC_2890 9046729 58.44 µM -1.67526454496853 0.0320523805306358 no 3189 0.0469411692806346 4567 903329
SGTC_2084 5306078 60.6385 µM -1.68234965390812 0.0315080962872149 no 3190 0.0462505289658647 4526 679340
SGTC_1985 st071382 65.5 µM -1.68438198512173 0.0313533884654432 no 3191 0.0460539350352553 4574 6123237
SGTC_2792 7535235 81.82 µM -1.68836298754737 0.0310521614443953 no 3192 0.0456707854268594 4548 1281891
SGTC_2666 tannic acid 100 µM -1.70227634592518 0.0300181423429332 no 3193 0.044351788413071 4569 16134267 A thiamine antagonist.
SGTC_2241 6772625 37.8075 µM -1.70239972517807 0.0300091022961864 no 3194 0.044340230768996 4390 2285411
SGTC_1494 4358-1428 177 µM -1.70433957995533 0.0298672649048402 no 3195 0.0441588323049427 4608 1564571
SGTC_1161 k007-0610 110 µM -1.7075507597969 0.0296336937539389 no 3196 0.0438598658050229 4528 5843850
SGTC_2844 9010103 25.97 µM -1.70798881910887 0.0296019485101604 no 3197 0.0438192085631536 4545 2480525
SGTC_2111 5486399 200 µM -1.71896686507985 0.0288155635089687 no 3198 0.0428102027643055 4560 689674
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.72211774624671 0.0285930925776544 no 3199 0.0425240954992582 4612 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_257 daunorubicin 18.5 µM -1.7424130782171 0.0271941129911962 no 3200 0.0407180945480706 4630 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2821 7996764 71.43 µM -1.74608798660752 0.0269470054091392 no 3201 0.0403978319943626 4566 2987135
SGTC_3354 9151612 71.43 µM -1.74794512547295 0.0268228426590767 no 3202 0.0402367649543107 4584 27261949
SGTC_2305 7443522 69.23 µM -1.75231136681911 0.02653280959573 no 3203 0.0398601412788334 4515 5415886
SGTC_1828 st055811 49 µM -1.75441963387947 0.0263937061119333 no 3204 0.0396793147526784 4607 5877589
SGTC_3267 9137951 49.47 µM -1.75507253456965 0.0263507515201257 no 3205 0.0396234507826538 4632 16643986
SGTC_1146 3579-1023 7 µM -1.75965214894908 0.0260510963730477 no 3206 0.0392334018621178 4639 X1146
SGTC_3246 9135460 32.98 µM -1.77406132731383 0.0251268018653098 no 3207 0.0380265033624517 4615 41446951
SGTC_1141 3253-0389 52.6 µM -1.77780861816141 0.0248909819401535 no 3208 0.0377176462870983 4615 5402031
SGTC_2942 9052777 62.25 µM -1.78425907328509 0.0244893973764209 no 3209 0.0371907886246721 4619 6469503
SGTC_727 3032-0951 202 µM -1.7850365799594 0.0244413616184883 no 3210 0.0371276918396556 4644 3652836
SGTC_1678 st019265 80.2 µM -1.78753309163698 0.024287657044017 no 3211 0.0369256843072315 4602 5367020
SGTC_1294 1000-1494 117 µM -1.78999680605506 0.0241367683095819 no 3212 0.0367272124291026 4633 712797 YDL207W GLE1
SGTC_3048 9093155 49.47 µM -1.79167319517646 0.0240345496754807 no 3213 0.0365926653521545 4626 25236002
SGTC_692 k241-0027 77.8 µM -1.79606617762163 0.0237684095964896 no 3214 0.0362419963824396 4650 3600480
SGTC_2917 7979103 53.79 µM -1.80094479074675 0.0234757566248642 no 3215 0.0358557911349728 4609 2980565
SGTC_1574 spiramycin 23.7 µM -1.80348759794186 0.0233244271307223 no 3216 0.0356558357210098 4605 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3138 9097216 49.47 µM -1.81251976129446 0.0227935192265465 no 3217 0.0349529616689661 4576 25237486
SGTC_2950 9072895 21.46 µM -1.8202314492493 0.0223483219840599 no 3218 0.0343618828537892 4553 17332245
SGTC_838 0109-0203 71.4 µM -1.82039372098369 0.0223390333665682 no 3219 0.0343495339806103 4657 759422
SGTC_552 k242-0005 476 µM -1.82309295774819 0.0221850030076526 no 3220 0.0341446565080395 4670 4088318
SGTC_1092 toremifene 6.32 µM -1.83849218492983 0.0213232971672155 no 3221 0.032994956197073 4645 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1376 2910-0861 41.3 µM -1.84642511995042 0.020890546104902 no 3222 0.0324152513062321 4587 1112859
SGTC_2716 st080858 38.6235 µM -1.84992364375226 0.0207020729596015 no 3223 0.0321622777876708 4620 5296050
SGTC_2431 5490079 200 µM -1.87071244244929 0.0196115928341918 no 3224 0.0306924746322734 4658 5722345
SGTC_584 0986-0246 15.4 µM -1.87133085426459 0.0195799156044288 no 3225 0.0306496182274072 4702 53315 YDR232W HEM1
SGTC_2009 4012297 12.05 µM -1.87393302006078 0.019447099183176 no 3226 0.0304698287918291 4595 45595307
SGTC_3253 9135987 49.47 µM -1.87402303498946 0.0194425184852695 no 3227 0.030463625127275 4660 4182430
SGTC_1779 st039427 55 µM -1.87509414969043 0.0193880816926755 no 3228 0.0303898861302872 4638 1124498
SGTC_1463 k081-0032 34.1 µM -1.88243573247473 0.0190184383932503 no 3229 0.0298884390732093 4163 977755
SGTC_579 4491-1009 110 µM -1.89387604767233 0.0184543794738075 no 3230 0.0291207322348102 4688 1271041
SGTC_2867 9039098 71.43 µM -1.90448638972432 0.0179440388437237 no 3231 0.0284234337829037 4636 6463460
SGTC_1776 st049249 45.9 µM -1.90553045885277 0.0178944774726003 no 3232 0.0283555760046184 4673 1822314
SGTC_2061 5245884 80.95 µM -1.90726967876461 0.0178121769108579 no 3233 0.0282428372593916 4640 573863
SGTC_2680 butyl paraben 22.24 µM -1.90904015387433 0.01772872921179 no 3234 0.0281284559790106 4725 7184 An antifungal and steroid mimetic.
SGTC_3128 9127691 49.47 µM -1.91084592908042 0.0176439615536227 no 3235 0.0280121916995098 4664 41316314
SGTC_3140 9094243 49.47 µM -1.91189243830642 0.0175949942606095 no 3236 0.0279449958913116 4636 19291112
SGTC_471 1-acyl-paf 4 µM -1.91505532388686 0.0174477039123587 no 3237 0.0277427242652528 4643 16759367
SGTC_1264 0783-0040 158 µM -1.9188713498529 0.0172714004414031 no 3238 0.0275003086408282 4585 2855798
SGTC_574 1315-0397 40 µM -1.92582041037122 0.0169542558091194 no 3239 0.0270634010103204 4647 6794277
SGTC_1698 5-fluorocytosine 1.055 µM -1.9299408480909 0.0167685669084809 no 3240 0.0268070836904324 4667 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2638 epoxomicin 18 µM -1.93770124669092 0.0164235628884014 no 3241 0.0263298408801325 4647 9915668 A protesome inhibitor.
SGTC_3017 9080681 49.47 µM -1.94139519472084 0.0162614875388062 no 3242 0.0261051803565638 4689 16451914
SGTC_380 3970-0968 6 µM -1.94420275968875 0.0161392211910498 no 3243 0.0259355025688309 4600 2891601
SGTC_4 0960-0234 25.671 µM -1.94498148373919 0.0161054484804963 no 3244 0.0258886034435458 4627 6821112
SGTC_1529 apigenin 74 µM -1.95491374756166 0.0156799778633539 no 3245 0.0252966258161858 4668 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_950 1165-0508 94.1 µM -1.95712201482478 0.0155867032427869 no 3246 0.0251665623531707 4653 6148369
SGTC_800 3448-7362 155 µM -1.95916619993935 0.0155007840539644 no 3247 0.0250466630440686 4721 15991913
SGTC_2649 anisomycin 9.56 µM -1.96191376273038 0.0153859418235886 no 3248 0.0248862626115445 4703 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1239 0337-0584 35.4 µM -1.97411659534965 0.014884675676648 no 3249 0.0241842433751156 4691 914301 YML130C ERO1
SGTC_2932 9016711 44.54 µM -1.9742556115652 0.014879047058034 no 3250 0.0241763427122057 4648 7117328
SGTC_690 glyoxal 20.3 µM -1.97716831122739 0.0147615351351582 no 3251 0.0240113041321643 4498 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3322 9139058 2.11 µM -1.9779793643595 0.0147289558892109 no 3252 0.02396551732617 4694 4908926 YPR165W RHO1
SGTC_336 4111-0029 111 µM -1.98093489161952 0.0146107579575123 no 3253 0.0237992877849105 4693 3131175
SGTC_696 1560-0013 611 µM -1.98136237017054 0.0145937299097679 no 3254 0.0237753252718291 4684 1650269
SGTC_2903 5923464 63.88 µM -1.99595656800313 0.0140225453527219 no 3255 0.0229693252523166 4693 2876576
SGTC_1157 4092-0394 27.6 µM -2.00135598089337 0.0138161623726706 no 3256 0.0226770204342183 4705 3659885
SGTC_804 1595-0054 20.9 µM -2.00748568586872 0.0135850454707084 no 3257 0.0223489866340793 4679 761523 Stimulates phospholipase C.
SGTC_2025 5147754 141 µM -2.00923749668448 0.0135196106333608 no 3258 0.022255976449587 4681 315777 YLR208W SEC13
SGTC_224 benfluorex 43.875 µM -2.01291636809063 0.0133830800149699 no 3259 0.0220617141567888 4698 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_801 0866-0028 10.1 µM -2.01567230822979 0.0132815829089196 no 3260 0.0219171265635199 4708 6849771
SGTC_414 piperonyl butoxide 100 µM -2.01759765783293 0.0132110703395565 no 3261 0.021816590504904 4694 5794 A potent inhibitor of cytochrome P450.
SGTC_43 0570-0105 72.5 µM -2.02815792096742 0.0128300439808387 no 3262 0.0212720664966087 4660 1114046 YDL195W SEC31
SGTC_1094 duloxetine 25.4 µM -2.03303347257629 0.0126573601780821 no 3263 0.0210245706882349 4703 60834 A selective serotonin reuptake inhibitor.
SGTC_3191 9110352 49.47 µM -2.03432989687307 0.0126117829483849 no 3264 0.0209591723857766 4654 17122424
SGTC_2422 chlorphenesin carbamate 384.24 µM -2.04861651967396 0.012118855412234 no 3265 0.0202498139959687 4642 2724 A muscle relaxant with antifungal properties.
SGTC_1688 st021091 57.6 µM -2.05197386741542 0.0120054712456465 no 3266 0.0200861010835705 4744 3656366
SGTC_1596 piperlongumine 63 µM -2.05389450445104 0.0119410221538586 no 3267 0.0199929516725267 4700 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_136 0097-0015 404.482 µM -2.06517994106099 0.011568356362227 no 3268 0.0194529888655085 4693 4861337
SGTC_1663 st014140 55.4 µM -2.0667593939455 0.0115170140724388 no 3269 0.0193784157348556 4739 4207120
SGTC_880 0833-0487 87.2 µM -2.08036290073853 0.0110829461000118 no 3270 0.0187461296966283 4697 76075
SGTC_144 4161-2749 112.381 µM -2.0814853941549 0.011047772880133 no 3271 0.0186947498121982 4713 797501 YMR168C CEP3
SGTC_865 0488-0499 301 µM -2.09684756698429 0.0105760702182694 no 3272 0.0180035356433517 4663 9634651
SGTC_304 1310-0298 97 µM -2.10155766440728 0.0104350036588699 no 3273 0.0177960208405298 4465 1550234
SGTC_1769 st044406 64.4 µM -2.10667594815606 0.0102835739570299 no 3274 0.0175728392165905 4698 670903
SGTC_616 4092-0450 108 µM -2.10720134688178 0.010268138482853 no 3275 0.0175500651211295 4717 787165
SGTC_811 0416-0114 265 µM -2.12372103413365 0.00979300920067855 no 3276 0.0168467387262436 4698 6612453
SGTC_3127 9126946 49.47 µM -2.12581341144261 0.00973422139711285 no 3277 0.0167593994379491 4669 27243249
SGTC_1337 1486-1011 40.3 µM -2.13930776209788 0.00936243594185938 no 3278 0.016205375738963 4723 X1337
SGTC_1461 k072-0203 53.8 µM -2.15086021929524 0.00905408196952027 no 3279 0.0157436171280816 4588 5418714
SGTC_2481 5478948 45.16 µM -2.15453513214673 0.00895787507008535 no 3280 0.0155991149518751 4693 77792
SGTC_393 acivicin 6.25 µM -2.1559326269171 0.00892152526188206 no 3281 0.0155444631771457 4609 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2956 9076196 2.52 µM -2.17152401485876 0.00852466450369811 no 3282 0.0149457919248455 4707 16423868
SGTC_2400 5203494 178.7 µM -2.18829200160364 0.00811522336374382 no 3283 0.0143241695738164 4653 6777674
SGTC_3068 9116768 49.47 µM -2.20081923462873 0.00782071211591697 no 3284 0.0138744116755883 4683 41904888
SGTC_396 dithiazanine 1.25 µM -2.20107871784855 0.00781471247142034 no 3285 0.0138652258158514 4706 10578 An antihelmenthic.
SGTC_3032 9089427 49.47 µM -2.2228927885496 0.00732459651107425 no 3286 0.0131115150852379 4707 17173707
SGTC_3076 9116187 49.47 µM -2.22372929129132 0.00730635389525655 no 3287 0.0130833316221762 4725 27241210
SGTC_3118 9124250 49.47 µM -2.23128287570758 0.00714342940076362 no 3288 0.0128311986297511 4715 1504786
SGTC_2833 9001315 45.46 µM -2.2352108610373 0.00705997940857546 no 3289 0.0127017543938858 4675 2989378
SGTC_2852 9023854 51.95 µM -2.24166939191096 0.00692463727383112 no 3290 0.0124913737480015 4718 19798528
SGTC_1462 k081-0014 26.5 µM -2.24283399591351 0.00690047763792615 no 3291 0.0124537606718011 4200 3270634
SGTC_2766 oltipraz 83.91 µM -2.25186003017061 0.00671574351739516 no 3292 0.0121655593431246 4720 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2904 7225135 42.03 µM -2.26492378931081 0.00645611169335232 no 3293 0.0117586783217115 4750 4446116
SGTC_2897 9048598 12.99 µM -2.29070639402604 0.00596963130772843 no 3294 0.0109902002863625 4726 6467404
SGTC_1253 0550-0034 176 µM -2.29297279048861 0.00592846317530461 no 3295 0.0109247857562791 4711 5969915
SGTC_914 3820-6779 408 µM -2.30429140184224 0.00572661075674838 no 3296 0.0106031456467176 4678 2893481
SGTC_1310 1188-0297 994 nM -2.30512129596664 0.00571205358663125 no 3297 0.0105798905564369 4675 1588352
SGTC_3103 9120822 49.47 µM -2.31408885912159 0.00555683631513218 no 3298 0.0103314242037922 4729 17141819
SGTC_1737 st035557 69.7 µM -2.31516150497785 0.00553852333443265 no 3299 0.0103020475448037 4646 5716916
SGTC_1519 esterone 74 µM -2.34926372491169 0.004983563623269 no 3300 0.00940528915273868 4739 698 A steroid.
SGTC_1177 0983-0204 23.6 µM -2.34958183303143 0.00497862895143907 no 3301 0.00939725614425859 4757 766818
SGTC_2699 st077704 54.6 µM -2.34996404813368 0.00497270557315648 no 3302 0.00938761221521031 4736 645852
SGTC_2920 7982904 15.77 µM -2.37203639932092 0.00464111031863506 no 3303 0.00884517393069685 4730 6456808
SGTC_3307 9126885 69.2785 µM -2.39209552084253 0.00435702529050973 no 3304 0.00837624089464518 4729 24824909
SGTC_1319 1306-0155 43.7 µM -2.40686771073052 0.0041578595110784 no 3305 0.00804499852522212 4764 3122360
SGTC_545 4218-0007 221 µM -2.41561758994268 0.00404376787862197 no 3306 0.00785427470022463 4753 2840508
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -2.4258846436976 0.00391347307821947 no 3307 0.00763556173459213 4719 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_264 promethazine 12.5 mM -2.43674703727911 0.0037797294850827 no 3308 0.00741002135122832 4681 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1346 1488-2224 62.4 µM -2.4422309889183 0.00371377728583363 no 3309 0.00729840187303837 4754 3722427
SGTC_1375 2910-0797 186 µM -2.45093353512621 0.00361123382985592 no 3310 0.0071243130325003 4752 742508
SGTC_2849 9019321 12.99 µM -2.4582578281042 0.00352690771707771 no 3311 0.00698064509801026 4740 16489627
SGTC_470 aa-861 153 µM -2.48180194160714 0.00326768473308047 no 3312 0.00653599549034467 4737 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_516 3992-2719 87.3 µM -2.48845204290085 0.00319763775561416 no 3313 0.00641502697766387 4695 5350887 YDR037W KRS1
SGTC_2834 9001755 58.44 µM -2.50254994866218 0.00305359122563949 no 3314 0.00616511127181646 4642 2989575
SGTC_3227 9130768 49.47 µM -2.51653908510628 0.00291645960476464 no 3315 0.00592568772107577 4785 17720899
SGTC_1900 st060200 72.8 µM -2.5238427509209 0.00284709226113388 no 3316 0.00580399199306143 4758 688945
SGTC_1933 st074711 15.9 µM -2.56832728411521 0.00245579558600376 no 3317 0.00510953112787015 4758 17250958
SGTC_2329 6138490 200 µM -2.58625223059519 0.00231238126903483 no 3318 0.00485129498825612 4741 720019
SGTC_438 sphingosine 6.67 µM -2.60253472128836 0.00218872770073969 no 3319 0.00462687221875013 4737 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1353 1498-1206 8.11 µM -2.6175189702805 0.00208026219528957 no 3320 0.00442857824723232 4776 6756808
SGTC_1366 1683-0113 21.9 µM -2.63372216822258 0.00196848058952638 no 3321 0.00422272816270521 4776 708623
SGTC_2600 tangeritin 87.95 µM -2.64426942849125 0.00189867855325893 no 3322 0.00409337309122314 4743 68077 A bioactive flavone.
SGTC_3083 9117465 49.47 µM -2.65137270167694 0.00185294452475822 no 3323 0.00400826629649809 4746 16420915
SGTC_1750 st081859 2.357 µM -2.66818248323963 0.00174867845095196 no 3324 0.0038131412154521 4724 5291695
SGTC_422 cantharidin 155 µM -2.67455954174728 0.00171054101947687 no 3325 0.00374137437464612 4739 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2670 beta-carotene 100 µM -2.68471600384787 0.00165136206399514 no 3326 0.00362957296425989 4794 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1033 k072-0102 21.3 µM -2.72618508700617 0.00142859201052213 no 3327 0.00320355295587617 4754 5965931
SGTC_2442 5158906 48.48 µM -2.73727042171475 0.00137388012387781 no 3328 0.00309756721032638 4768 1893835
SGTC_578 3460-0051 92 µM -2.74004107507683 0.00136050788139273 no 3329 0.00307157532636464 4790 2876744
SGTC_1685 st024049 53.0905 µM -2.74788506622621 0.00132329208122889 no 3330 0.00299905153982826 4790 1941139
SGTC_2430 5571206 200 µM -2.74862344979085 0.00131983718138466 no 3331 0.00299230469942297 4749 1731771
SGTC_870 0573-2213 57.6 µM -2.76064224092025 0.00126474837800698 no 3332 0.00288439155414797 4785 3916321
SGTC_2289 7946404 165.07 µM -2.80140092200029 0.00109321976029448 no 3333 0.0025440631239875 4765 1246120 YPR165W RHO1
SGTC_3301 9125354 19.7965 µM -2.92609663856806 0.000692181793642028 yes 3334 0.00171622147646217 4780 41905162
SGTC_1984 st072354 53.1 µM -2.95523670447685 0.000620557372229135 yes 3335 0.00156214622611223 4767 5762938
SGTC_2763 lisinopril 49.32 µM -3.03120537326048 0.000464759004193893 yes 3336 0.00121789754286638 4774 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_62 0180-0423 3.232 µM -3.05729336065122 0.000420226704790349 yes 3337 0.00111672787141036 4779 30102 YGL099W LSG1
SGTC_1190 1486-1332 13 µM -3.07244596573331 0.000396212540525037 yes 3338 0.00106156133832499 4795 4150046
SGTC_3318 9139014 38.6185 µM -3.0919486862347 0.000367177766438954 yes 3339 0.000994236095966211 4796 16643984
SGTC_911 3456-4043 236 µM -3.10016904572004 0.000355542228133809 yes 3340 0.000967051116114991 4776 914281
SGTC_1350 1495-0454 146 µM -3.12299775989697 0.00032500144409109 yes 3341 0.000895095552282486 4797 1069057
SGTC_1344 1488-0097 29.1 µM -3.1337787084 0.000311443185434285 yes 3342 0.00086285473150537 4792 747966
SGTC_1370 2001-0092 44.6 µM -3.2256527058861 0.000215493321798525 yes 3343 0.000628428834157829 4754 790957
SGTC_3192 9110362 49.47 µM -3.26778949633353 0.000181441727998118 yes 3344 0.000541954753714884 4795 16649480
SGTC_1682 st012968 530 nM -3.27021254660223 0.000179645414576621 yes 3345 0.000537333516501795 4786 24207270
SGTC_877 0771-0151 33.1 µM -3.29903544247878 0.00015951518255183 yes 3346 0.000485088306096526 4802 6166523
SGTC_1336 1486-0901 104 µM -3.45476343061069 8.26212304317229e-05 yes 3347 0.000275387931752531 4801 5006114
SGTC_2665 lovastatin 100 µM -3.48392812023312 7.28278939439195e-05 yes 3348 0.000247056085010969 4808 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1316 1272-0050 65.9 µM -3.51207254066526 6.4422170963159e-05 yes 3349 0.000222313310375415 4808 7340392
SGTC_2900 5328528 85.29 µM -3.57299002803079 4.92553806519471e-05 yes 3350 0.000176464102956846 4787 795359
SGTC_2651 TUB2.036 5 µM -3.73531768852911 2.36110860930653e-05 yes 3351 9.37391801423549e-05 4763 15992207 YFL037W TUB2
SGTC_919 tnp00227 403.569 nM -3.93336696575337 9.25465154398495e-06 yes 3352 4.18821037486859e-05 4786 1269246 A methoxyflavone. YNL221C POP1
SGTC_310 1273-0058 1.06 µM -4.27072085301916 1.69796521065769e-06 yes 3353 9.7421081612564e-06 4646 2734232
SGTC_2582 agaric acid 100 µM -4.82259609795525 8.05706437711046e-08 yes 3354 7.08508611984726e-07 4749 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_58 0957-0393 9 µM -5.13532470976882 1.23066889819335e-08 yes 3355 1.40828648182769e-07 4701 6997992
SGTC_3144 9087057 49.47 µM -5.24395042649319 6.24449441339501e-09 yes 3356 7.85872230777505e-08 4805 17249618