SGTCid condition conc unit SEC5|YDR166C.score SEC5|YDR166C.strain.pval SEC5|YDR166C.strain.significant SEC5|YDR166C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_312 4092-0653 6.84 µM 8.0249917005979 1.67369273297613e-17 yes 1 5.07664037926609e-16 8 1148278 SGTC_57 miconazole 162.5 nM 6.82876619360873 3.63617686920259e-13 yes 2 4.28240140597457e-12 13 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_207 4185-0010 4.486 µM 6.04190332475141 1.1070692119819e-10 yes 3 7.61533603955465e-10 9 3761753 SGTC_320 4092-0846 5.34 µM 5.83234078210716 4.53284984721404e-10 yes 4 2.73275745929988e-09 11 1359356 SGTC_206 4546-0025 72.014 µM 5.53661072735753 3.05601577561947e-09 yes 5 1.54190453583668e-08 6 6620745 YIL048W NEO1 SGTC_773 4358-1457 44.6 µM 5.47224036501064 4.57205457888455e-09 yes 6 2.22190767239695e-08 6 1186886 SGTC_204 PMA1.184 62.41 µM 5.20168063290363 2.36723655452014e-08 yes 7 9.87471959281171e-08 4 2252213 YGL008C PMA1 SGTC_3211 9128781 49.47 µM 4.98897930812038 8.15840282288761e-08 yes 8 3.03495737308419e-07 9 17194361 SGTC_193 1273-0060 1.558 µM 4.87300001386309 1.56931497929039e-07 yes 9 5.49581076470865e-07 4 2847393 YHR072W ERG7 SGTC_2249 haloperidol 116.36 µM 4.57929533284852 7.71148724192871e-07 yes 10 2.33272527727951e-06 28 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1072 oxiconazole 14.9 nM 4.4174221973758 1.7826666677534e-06 yes 11 4.99425033542667e-06 15 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 4.23636922347714 4.40281890708052e-06 yes 12 1.13581562655914e-05 10 6708760 SGTC_685 1278-0033 54.9 µM 4.06299968404506 1.0127927804225e-05 yes 13 2.42230475903931e-05 9 3590572 SGTC_67 0335-0847 266 µM 4.04123152977775 1.12193181776203e-05 yes 14 2.65856147454842e-05 20 4552207 YOR254C SEC63 SGTC_3037 9091026 49.47 µM 3.84812736378352 2.7207598399501e-05 yes 15 5.95120861704048e-05 22 25236398 YIL048W NEO1 SGTC_1237 0330-0133 46.1 µM 3.76382426087989 3.9561592519675e-05 yes 16 8.36672507209897e-05 11 X1237 YHR072W ERG7 SGTC_2778 tioconazole 65.09 nM 3.5357251102975 0.00010491924992162 yes 17 0.000203328804398225 37 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1042 0350-0096 82 µM 3.44153924153177 0.000154463826897501 yes 18 0.000289207283822494 9 3122515 SGTC_2294 7971431 200 µM 3.43319938613272 0.000159773727379882 yes 19 0.000298251632141381 6 5741572 SGTC_767 0929-0023 86 µM 3.3913518211819 0.000189095592280942 yes 20 0.000347743798642566 19 1204563 SGTC_2896 9052656 71.43 µM 3.37966060320273 0.000198144818210448 yes 21 0.000362876955111585 28 6469436 SGTC_266 formosanin C 406 nM 3.37277474639387 0.000203662302416846 yes 22 0.00037207401601718 29 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2587 piperic acid 92.2 µM 3.34187355867816 0.000230236154642417 yes 23 0.000416074791355293 11 5370536 SGTC_3326 9140064 16.379 µM 3.32113216897708 0.000249851074276217 yes 24 0.000448265353254963 11 1868434 SGTC_1910 st062352 60.4 µM 3.29677063170587 0.00027487611460696 yes 25 0.000489016688924313 7 2245730 SGTC_3206 9114350 49.47 µM 3.28403141752051 0.000288873697387778 yes 26 0.000511667569043182 9 17087243 SGTC_2356 9061756 188.97 µM 3.25847178015703 0.000318981582468938 yes 27 0.000560070081504799 9 20104043 SGTC_874 0599-0792 117 µM 3.25263327951649 0.000326256800913641 yes 28 0.000571704796092677 18 765305 SGTC_815 1582-0027 36.9 µM 3.24469780581792 0.000336392582094583 yes 29 0.000587876628015412 12 3128206 SGTC_1631 benzylvanillin 81.9 µM 3.23181459948448 0.000353473447505966 yes 30 0.00061503418529469 12 75506 SGTC_306 1672-3436 11.6 µM 3.21855454826841 0.000371892913396246 yes 31 0.000644192313169287 9 6797378 SGTC_3035 9091303 49.47 µM 3.21681237430927 0.00037437814641934 yes 32 0.000648116692613382 2 25237002 SGTC_2036 5160441 105 µM 3.18937423221212 0.000415609804290933 yes 33 0.000712905827941834 33 134534 YIL048W NEO1 SGTC_205 1486-1330 71.903 µM 3.18786077379798 0.000418002353385414 yes 34 0.000716647655720634 5 4118834 SGTC_1286 0929-0070 131 µM 3.18547458415249 0.000421800522937805 yes 35 0.000722583986761997 11 1420408 SGTC_892 0929-0076 29 µM 3.17020596392341 0.000446871777259247 yes 36 0.000761654595077451 11 5751038 SGTC_2910 7948405 25.97 µM 3.16096349937316 0.000462711960882414 yes 37 0.000786241010781816 8 2971328 SGTC_1204 4049-0315 18.3 µM 3.15550827907616 0.000472303929032855 yes 38 0.000801093595582264 18 588402 SGTC_1289 0976-0073 69.1 µM 3.07642097604088 0.000633720234221138 yes 39 0.00104750913690662 9 3391136 SGTC_2942 9052777 62.25 µM 3.06822288592562 0.000653086857796539 yes 40 0.00107667971404008 19 6469503 SGTC_2597 laccaic acid a 100 µM 3.0410421119571 0.000721272076272894 yes 41 0.00117880426967906 20 5491415 A textile dye. SGTC_757 1066-0008 322 µM 3.02967078557874 0.000751698170599435 yes 42 0.00122410221020806 12 6842497 SGTC_252 miconazole 1.30953 nM 3.02830317863317 0.000755436052409193 yes 43 0.00122965610125358 30 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1470 k295-0292 231 µM 2.96847534167633 0.000936727987572015 yes 44 0.00149640556869936 11 5045612 SGTC_3143 9086658 49.47 µM 2.95851496107668 0.000970531317216222 yes 45 0.00154562617892463 26 25236626 SGTC_683 panaxydol 45 µM 2.92509876629824 0.0010922867394373 no 46 0.00172173457109106 10 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1371 2421-0008 32.7 µM 2.90171447759667 0.00118565119708239 no 47 0.00185563315064805 46 2827552 SGTC_1995 st072814 61.1 µM 2.86862530929568 0.00133027560171627 no 48 0.0020612992893796 10 5769371 SGTC_1645 Cervolide 78 µM 2.85384719434545 0.00139993279538986 no 49 0.00215966507762106 14 23173 A fragrance. SGTC_689 0833-0039 98 µM 2.84710989218097 0.00143278155122859 no 50 0.00220590649290852 20 5374726 SGTC_1078 idebenone 36.1 µM 2.81693056668561 0.00158873463714505 no 51 0.00242425030753654 21 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2702 st077768 96.8 µM 2.8137929332859 0.00160580615535719 no 52 0.00244803774293064 16 6484119 SGTC_2311 7694451 200 µM 2.81242995314836 0.00161327392604587 no 53 0.0024584365684085 30 2163142 SGTC_324 1315-0088 19.6 µM 2.80464333395124 0.00165654695879368 no 54 0.00251861427013636 30 6787421 SGTC_1928 4'-methoxychalcone 40.3 µM 2.7678443878009 0.00187570714318973 no 55 0.00282141958407863 12 641818 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.74294513762936 0.00203861046223458 no 56 0.00304454289123319 15 689007 SGTC_1306 1185-0270 9.02 µM 2.71188189810007 0.00225980114784893 no 57 0.00334512124186104 22 1548076 SGTC_1819 st053448 58.6 µM 2.66489242175206 0.00263588644932926 no 58 0.00385064773463538 22 2857616 SGTC_2310 7668677 200 µM 2.65752345951418 0.00269974183137594 no 59 0.00393585558264347 37 2197143 SGTC_2297 7971671 152.32 µM 2.63626581569816 0.00289184987107935 no 60 0.00419120190602213 29 909016 SGTC_2790 5423970 71.43 µM 2.63511470299971 0.00290259607351629 no 61 0.00420544275524935 38 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2492 derrusnin 100 µM 2.6277471098055 0.00297223300017415 no 62 0.00429761941241853 20 1715307 Part of coumarin class of compounds. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.62215787174345 0.00302606172830937 no 63 0.00436874730763679 32 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_456 gingerol 170 µM 2.61259531911718 0.00312019625214786 no 64 0.0044928815548209 14 442793 A herb. SGTC_1392 3455-1037 33.9 µM 2.60360916838253 0.00321105077479736 no 65 0.00461239420150683 19 981132 SGTC_768 0384-0033 77.3 µM 2.58829040076076 0.00337143159279847 no 66 0.00482268134249509 43 3965305 YMR134W ERG29 SGTC_2328 6201408 200 µM 2.55931656224878 0.00369458651994956 no 67 0.00524390948204014 39 2890418 SGTC_551 k048-0028 34.9 µM 2.55366164530786 0.00376080626719219 no 68 0.00532983933278765 35 6836383 SGTC_898 1000-0849 28.3 µM 2.54225836480487 0.00389758599784973 no 69 0.00550693631169681 29 6751807 SGTC_2395 5646831 180.19 µM 2.53798390761145 0.00394999474899434 no 70 0.00557465555106675 21 6808628 SGTC_2715 st079500 56.4 µM 2.53612190239272 0.00397302134582279 no 71 0.00560438543673613 18 28246688 SGTC_2568 diosmetin 100 µM 2.53495087101663 0.00398756447962143 no 72 0.00562315486800909 39 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_489 paxilline 115 µM 2.49896367426733 0.00445838392335152 no 73 0.00622785390281305 19 105008 A toxic potassium channel blocker. SGTC_2484 5809818 12.04 µM 2.49720133665976 0.00448266632394062 no 74 0.00625889308772837 24 2870548 SGTC_1635 st007035 42.4 µM 2.48761845967107 0.00461678290017633 no 75 0.00643008085313179 45 3716403 SGTC_1081 sertraline 6 µM 2.48685031523052 0.00462768688946221 no 76 0.00644398061814317 23 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3072 9116419 49.47 µM 2.47337485192542 0.00482274839768891 no 77 0.00669218362895393 28 17170162 SGTC_291 SEC14.278 35.5 µM 2.46901549410822 0.00488740247114362 no 78 0.00677426759953815 30 1068044 SGTC_2807 7945238 51.95 µM 2.44679180978955 0.005229159899597 no 79 0.00720670340339645 31 17148797 SGTC_1062 mesoridazine 14.2 µM 2.44116528326677 0.00531898985508972 no 80 0.0073199763123775 28 4078 A neuroleptic. SGTC_479 n-linoleoylglycine 10 µM 2.42880601949431 0.00552114451549258 no 81 0.00757431745353654 21 6433346 An anti-infammatory. SGTC_658 3253-0951 102 µM 2.42692217056933 0.0055525500259565 no 82 0.00761376107793632 36 1184878 SGTC_2815 7968870 71.43 µM 2.41686039990936 0.00572299124628278 no 83 0.00782750992850101 29 2977326 YHR190W ERG9 SGTC_201 4262-0159 12.803 µM 2.41223962773179 0.00580280910616597 no 84 0.00792742864169 37 1341029 SGTC_1373 2887-0003 58.5 µM 2.40698342388237 0.00589480272891308 no 85 0.0080424499602981 47 776948 SGTC_198 3454-2873 16.191 µM 2.39349192035508 0.00613687665836605 no 86 0.00834442444685395 23 710957 SGTC_1699 st031318 29.054 µM 2.38598316458991 0.0062753842647869 no 87 0.00851676540451025 29 5340658 SGTC_850 0388-0143 75.9 µM 2.35904037934774 0.00679542846415864 no 88 0.00916113098691754 25 67273 SGTC_3353 9151644 39.2805 µM 2.34339466860684 0.00711458430563733 no 89 0.00955457855471144 23 4909158 SGTC_570 0987-0065 62.6 µM 2.33318318536439 0.00732995335248687 no 90 0.0098192664817836 26 3104428 SGTC_1277 0873-0036 22 µM 2.32958462098995 0.00740720835801522 no 91 0.00991405787990287 24 5965735 SGTC_870 0573-2213 57.6 µM 2.32071049713418 0.00760079473501011 no 92 0.0101512369031177 20 3916321 SGTC_823 0417-1665 178 µM 2.3206962858951 0.00760110828844964 no 93 0.0101516206632749 32 3429856 SGTC_3315 9136395 68.55 µM 2.29777567522545 0.00812188877817554 no 94 0.0107872799507162 49 16876844 SGTC_2333 9017922 200 µM 2.25950685514196 0.00906145644666208 no 95 0.0119259371866877 23 3163164 SGTC_1209 2323-2347 50.3 µM 2.25790826995067 0.00910269561858276 no 96 0.0119756894640456 35 5412760 SGTC_3304 9125678 46.087 µM 2.25712380182812 0.00912299281428698 no 97 0.0120001699958863 55 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2353 9059630 146.67 µM 2.24319621728755 0.00949000713295649 no 98 0.0124420820653448 24 4779114 SGTC_12 0849-0099 9.267 µM 2.24295646517768 0.00949643641769954 no 99 0.0124498110017046 35 6071388 SGTC_894 0960-0238 55.9 µM 2.23473193461419 0.00971930707241197 no 100 0.0127174763766777 39 6741907 YDL195W SEC31 SGTC_947 3447-0010 211 µM 2.23362823445151 0.00974956055112856 no 101 0.0127537722823134 43 748350 SGTC_3138 9097216 49.47 µM 2.20924392845076 0.010439265975301 no 102 0.013578839468238 40 25237486 SGTC_824 1304-0008 100 µM 2.20876926313015 0.0104531033794974 no 103 0.0135953469942787 38 768245 SGTC_9 0092-0002 10.449 µM 2.20462989157466 0.0105744530482837 no 104 0.0137400382171147 55 759368 SGTC_1323 1348-1351 11.2 µM 2.19748167220723 0.0107869009800694 no 105 0.0139930320063203 36 6989654 SGTC_1321 1326-2144 215 µM 2.18787559480822 0.0110782435218489 no 106 0.0143393327337325 39 3513030 SGTC_3228 9131799 49.47 µM 2.16967493523055 0.0116490580604112 no 107 0.0150157400746868 36 17015818 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.16397239405053 0.0118330789612916 no 108 0.0152332340721381 29 61125 An anti-inflammatory. SGTC_1712 st032288 53.4 µM 2.16117360059313 0.0119243150725169 no 109 0.0153409659338116 80 2883011 SGTC_256 clotrimazole 625 nM 2.15746712656066 0.0120460787651591 no 110 0.0154846429238405 62 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_423 5-fluorouracil 457 µM 2.15479526617096 0.0121345210591877 no 111 0.0155889294289314 78 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1794 st048918 76.9 µM 2.15170906907581 0.0122373785387126 no 112 0.0157101377054828 29 672303 SGTC_1505 k297-0037 20.6 µM 2.14619942085841 0.0124228844678216 no 113 0.015928535888698 32 4089396 SGTC_1213 1315-0166 115 µM 2.13074820994907 0.0129561628718724 no 114 0.016554945529173 61 768401 SGTC_2354 9060492 162 µM 2.11924675146343 0.0133658659080158 no 115 0.0170348095762998 33 6471895 SGTC_3161 9100388 49.47 µM 2.11667041844265 0.0134591584215036 no 116 0.0171439145526082 36 25236368 SGTC_2034 5197015 53.07 µM 2.10104650362083 0.0140370501969738 no 117 0.0178184421197056 48 780676 SGTC_413 propylparaben 100 µM 2.0982978897283 0.014140896759046 no 118 0.0179394194164221 41 7175 A pharmaceutical preservative. SGTC_3122 9126309 49.47 µM 2.08553177836834 0.0146319402351363 no 119 0.0185105283364905 53 17591206 SGTC_1646 st011709 75.6 µM 2.0740339759633 0.0150866864556473 no 120 0.0190380777718393 53 5757843 SGTC_2326 6164455 177.58 µM 2.07156250820332 0.0151860052034593 no 121 0.0191531296933102 64 2888790 SGTC_1012 4112-3522 18 µM 2.06803489375123 0.0153287391779985 no 122 0.0193183710160032 41 3112398 SGTC_1655 st012546 55.1 µM 2.06567520444022 0.0154248584593558 no 123 0.0194295790436617 38 720985 YLR208W SEC13 SGTC_1883 5-benzylidenerhodanine 20 µM 2.06349092829123 0.0155142932086844 no 124 0.0195330044113143 48 1273210 SGTC_152 4469-0003 551.229 µM 2.05998267070882 0.0156588695980385 no 125 0.0197000987569135 86 697280 SGTC_796 1234-0020 70.7 µM 2.05831507711888 0.015727995991198 no 126 0.019779948902816 43 46495034 SGTC_1494 4358-1428 177 µM 2.05201293035727 0.0159916064812091 no 127 0.0200842029003079 40 1564571 SGTC_2564 betulinic acid 100 µM 2.05101170869715 0.0160338329856189 no 128 0.0201329032590151 54 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_556 4058-0063 51.5 µM 2.04586709223494 0.0162523173269774 no 129 0.0203847244062913 37 6615692 SGTC_1107 amlodipine 47 µM 2.03455942775716 0.0167415149385869 no 130 0.0209476116267215 42 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_42 0133-0086 60.653 µM 2.03380517106748 0.0167745894207395 no 131 0.0209856214819747 76 162923 Model of phenazepam hydroxylation. SGTC_1597 7-benzyloxygramine 47.5 µM 2.02888521696063 0.0169917058274235 no 132 0.0212349914110557 103 260807 SGTC_2211 7117706 200 µM 2.02028004877477 0.0173772269105669 no 133 0.021677173544153 25 822771 SGTC_3078 9116413 49.47 µM 2.01547280943306 0.0175958310117862 no 134 0.0219275661326107 54 17177322 SGTC_1140 3229-1848 2.98 µM 2.01280040594746 0.0177183677397083 no 135 0.0220678156029051 37 2849525 SGTC_2428 5615643 7.78 µM 2.01073945458756 0.0178133643865501 no 136 0.0221764921334313 71 2253075 SGTC_2190 6049624 200 µM 2.00874617612073 0.0179056547183545 no 137 0.022282029482605 36 2265554 SGTC_3019 9081971 49.47 µM 2.00142642980642 0.0182480708920324 no 138 0.0226732274014626 51 16451803 SGTC_1471 k673-0312 37 µM 1.99546182632537 0.018531204768965 no 139 0.0229962668011324 40 24099884 SGTC_1874 staurosporine 7.6 µM 1.98330743370646 0.0191197531345716 no 140 0.0236665497834186 53 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_235 0330-0087 5 mM 1.98171225248025 0.0191981633505868 no 141 0.0237557275512283 44 46494818 YHR062C RPP1 SGTC_113 0099-0221 2.5 µM 1.97952304353883 0.0193062175046346 no 142 0.0238785739101667 49 89219 SGTC_1378 2093-0007 380 nM 1.9746863022542 0.0195467810200193 no 143 0.0241518791713003 56 3618014 SGTC_1529 apigenin 74 µM 1.97442574308339 0.0195598123188826 no 144 0.0241666766337546 50 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3167 9103034 49.47 µM 1.97186864047998 0.0196880921958618 no 145 0.0243123020140551 43 5127859 SGTC_2924 9010168 62.78 µM 1.96643219120467 0.0199631925964625 no 146 0.0246243539858698 46 2993929 SGTC_528 3492-0019 172 µM 1.95904480675619 0.020342237453344 no 147 0.0250537698222857 84 2869262 SGTC_1947 st076332 61.6 µM 1.95861711417058 0.0203643678197076 no 148 0.0250788219008865 47 24208416 SGTC_1728 st035614 33.7865 µM 1.95688718485531 0.0204540889476106 no 149 0.0251803667850253 64 15945546 SGTC_3203 9113543 49.47 µM 1.95281850410316 0.020666428341289 no 150 0.0254205525578835 66 17018012 SGTC_2317 5986382 200 µM 1.95169751960672 0.0207252581349673 no 151 0.025487063636826 50 877883 SGTC_3163 9099914 49.47 µM 1.94992518870188 0.020818560229601 no 152 0.0255925182041693 32 16268368 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.94221520195945 0.0212285914801562 no 153 0.0260555267514672 58 688798 SGTC_976 1348-1067 47.6 µM 1.94221245665694 0.0212287386881623 no 154 0.0260556928549094 54 5310671 YGL099W LSG1 SGTC_541 4513-1321 94 µM 1.93264616560472 0.0217469706652364 no 155 0.0266399006004265 70 747515 SGTC_1749 st037932 54.2 µM 1.9309562033866 0.0218396223793432 no 156 0.0267442343963049 63 594497 SGTC_1921 5740136 50 µM 1.92724608888443 0.022044198213502 no 157 0.0269744843398337 45 1774243 SGTC_234 nsc-17383 10.7 µM 1.92622966684383 0.0221005252309767 no 158 0.027037851521921 56 408974 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.9186387822742 0.0225250421895118 no 159 0.0275150319488078 57 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2425 5628681 7.85 µM 1.91761500964459 0.0225828190195568 no 160 0.027579922753463 51 5714958 SGTC_2231 micatex 6.853 µM 1.90980312846744 0.0230278113109856 no 161 0.0280792831723209 56 20737 An antifungal of unknown mechanism. SGTC_3274 9138298 49.47 µM 1.90496220690376 0.0233072560875488 no 162 0.0283924919875955 63 17015756 SGTC_2090 5301565 104.445 µM 1.90169898704702 0.02349723318338 no 163 0.0286052591902648 71 2056344 SGTC_2452 5863136 48.41 µM 1.90139749157475 0.0235148511048587 no 164 0.028624983929018 62 2184096 SGTC_1428 4049-0204 61.7 µM 1.90136321269978 0.0235168548980983 no 165 0.0286272272719182 65 X1428 SGTC_2592 piperlongumine 83.33 µM 1.89740580648909 0.0237491550557872 no 166 0.028887199940099 58 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3083 9117465 49.47 µM 1.8903402648118 0.0241687005620957 no 167 0.0293562334767246 56 16420915 SGTC_1214 0358-0031 63.7 µM 1.88782041006338 0.0243198255565703 no 168 0.0295250320998107 64 4301366 SGTC_755 1995-0008 37.3 µM 1.87799240082809 0.0249168509038669 no 169 0.0301911023315931 33 689533 SGTC_562 3772-2733 112 µM 1.87754961493814 0.0249440357716265 no 170 0.0302214019719552 59 2876874 YIL048W NEO1 SGTC_2335 9018011 154.17 µM 1.86911815056803 0.0254664499615085 no 171 0.030803189161326 72 6458208 SGTC_1393 3470-5649 58.2 µM 1.86907724369731 0.0254690067207212 no 172 0.030806034256168 37 4108395 SGTC_1029 k015-0030 64.7 µM 1.86792285385897 0.0255412470192047 no 173 0.0308864124239141 66 2208316 SGTC_1035 k081-0041 55.2 µM 1.85684605747069 0.0262431808204346 no 174 0.0316665294483766 60 731709 SGTC_3171 9103192 49.47 µM 1.85309107541489 0.0264847637153674 no 175 0.0319346528946845 40 13018434 SGTC_2855 9016525 58.44 µM 1.8520219791322 0.0265538846588507 no 176 0.0320113334158062 69 43811474 SGTC_3174 9107204 49.47 µM 1.84902255701236 0.0267486131473861 no 177 0.0322272778154876 47 3938802 SGTC_2387 9077560 195.08 µM 1.83855022924941 0.0274378715028623 no 178 0.0329906837437879 62 5303272 SGTC_1467 k284-1082 293 µM 1.82889648862344 0.028086310274135 no 179 0.0337075581868919 57 3334705 SGTC_1011 4112-3381 17.4 µM 1.82542187231678 0.0283228004118398 no 180 0.0339686955708939 62 2877139 SGTC_2570 licareol 100 µM 1.82035099270672 0.0286709079956759 no 181 0.034352785247177 71 443158 SGTC_3184 9108758 49.47 µM 1.81588363024412 0.0289805262203986 no 182 0.0346941124530377 50 902885 SGTC_1309 pyrazolanthrone 13.4 µM 1.81235753872086 0.0292268657680908 no 183 0.0349654846300082 73 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1898 st060199 18.6 µM 1.81126667750011 0.0293034267850678 no 184 0.0350497906097415 60 688866 SGTC_1173 0443-0020 122 µM 1.80617004492913 0.0296633391049034 no 185 0.0354458911983244 67 5331295 SGTC_197 4544-0043 41.561 µM 1.79452182928249 0.0304996957483764 no 186 0.0363649587952402 89 896523 SGTC_1231 0242-0792 125 µM 1.7921146935122 0.0306749443851239 no 187 0.0365572978358148 60 3707635 SGTC_483 fpl-64176 144 µM 1.78825047340638 0.0309580174727046 no 188 0.0368678031929225 49 3423 SGTC_2437 5741531 144.16 µM 1.78318127568212 0.0313326358367759 no 189 0.0372783997265308 88 2262990 SGTC_1208 2323-2347 50.3 µM 1.77828356946115 0.0316981336437383 no 190 0.0376786467489714 53 5412760 SGTC_480 am 92016 50 µM 1.77660552477817 0.0318241673979174 no 191 0.0378165830064997 76 2129 K+ channel blocker. SGTC_2724 maprotiline 69.64 µM 1.77656644931703 0.0318271071833469 no 192 0.0378197999357639 65 4011 A tricyclic antidepressant. SGTC_602 3130-1533 38.1 µM 1.77594089146241 0.0318742006680132 no 193 0.0378713300701458 86 720941 SGTC_1888 azatryptophan 97.5 µM 1.77024424379134 0.0323057120248706 no 194 0.0383432309163234 57 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2974 9094440 9.66 µM 1.76440581786845 0.0327529537839007 no 195 0.0388318396854648 92 25236134 SGTC_420 mitomycin C 81.9 mM 1.76069422014014 0.0330399190354567 no 196 0.0391450857745237 81 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_604 1000-0114 314 µM 1.75876741492465 0.033189706576634 no 197 0.039308510762775 62 1572745 SGTC_2371 9071574 200 µM 1.758308500147 0.0332254644247169 no 198 0.0393475160861781 60 45596039 SGTC_51 1013-0126 23.419 µM 1.75816345416634 0.033236772754883 no 199 0.0393598507734045 61 1627850 SGTC_2824 7998404 51.95 µM 1.7579320530006 0.0332548202229878 no 200 0.0393795356050526 76 837851 SGTC_866 0495-0101 262 µM 1.75721824334637 0.0333105426104465 no 201 0.0394403084248668 78 635694 SGTC_2352 9027995 87.8 µM 1.75430850167683 0.0335384829911466 no 202 0.0396888299033334 59 2997347 SGTC_2414 st077232 92.9 µM 1.73959905783654 0.0347105084178209 no 203 0.0409647224060666 64 729801 SGTC_591 4299-0174 154 µM 1.73805327877466 0.0348356032133402 no 204 0.041100713140721 58 5509088 SGTC_1210 3013-0140 750 nM 1.7376842970442 0.0348655183431548 no 205 0.0411332285675425 65 905973 SGTC_1133 3473-0247 50 µM 1.73319636479251 0.0352310677449278 no 206 0.0415303864679681 123 711311 SGTC_2222 6885208 172.143 µM 1.72924057204025 0.0355558749556976 no 207 0.0418830238841439 46 609514 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.72383952846864 0.0360033106604588 no 208 0.0423684082431516 79 442882 SGTC_1911 st060208 74.3 µM 1.72312574153579 0.0360627860471836 no 209 0.042432894350876 76 688783 SGTC_2250 alverine citrate 130 µM 1.72250392964824 0.0361146632872913 no 210 0.0424891357786885 110 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2821 7996764 71.43 µM 1.72124962949542 0.0362194944546287 no 211 0.042602767740701 68 2987135 SGTC_212 3807-4682 38.772 µM 1.71917440042471 0.0363934837177132 no 212 0.0427913103362095 81 3125501 YBL034C STU1 SGTC_593 1203-0218 61.7 µM 1.71670283373928 0.0366015941710851 no 213 0.0430167410670788 79 3666956 SGTC_974 1326-0144 138 µM 1.71486809369575 0.0367567114275956 no 214 0.0431847067928801 73 5411856 SGTC_3172 9105863 49.47 µM 1.71480662213424 0.0367619178065039 no 215 0.0431903435140207 45 2348785 SGTC_2285 7945142 200 µM 1.70749390442939 0.0373855905283751 no 216 0.0438651449061433 76 2970608 SGTC_3098 9119039 49.47 µM 1.70408249327044 0.0376794784763733 no 217 0.0441828383857859 78 17161528 SGTC_3134 9127454 49.47 µM 1.70381054511144 0.0377029873396958 no 218 0.0442082436412008 46 24262820 SGTC_2952 9073731 13.78 µM 1.69960711506301 0.0380678827233229 no 219 0.0446024255658683 78 16457353 SGTC_2 0422-0095 29 µM 1.6988742314463 0.0381317975431415 no 220 0.0446714416091453 66 6790840 SGTC_1621 st003705 32.4 µM 1.69840641506561 0.0381726415808667 no 221 0.0447155410842532 78 24207032 SGTC_1114 scopoletin 1.73284 µM 1.69809970024996 0.0381994395483934 no 222 0.0447444730807204 63 5280460 A coumarin with genotoxic properties. SGTC_3135 9127742 49.47 µM 1.69063140559939 0.038856700127304 no 223 0.0454536113021212 68 3643468 SGTC_1442 4112-3290 3 µM 1.68899184911587 0.0390022182521651 no 224 0.0456104959885297 61 704353 SGTC_3335 9143315 29.6265 µM 1.68185191396332 0.0396411019724318 no 225 0.046298779538869 63 4899691 SGTC_2922 7999257 32.47 µM 1.67953196587843 0.0398505143183531 no 226 0.0465242071888381 76 2988377 SGTC_59 0330-0160 1.33 µM 1.67795136876245 0.0399937028083456 no 227 0.0466782965712617 70 4293482 SGTC_2205 7238770 200 µM 1.67717791940464 0.0400639228620431 no 228 0.0467538477386805 60 279867 SGTC_3022 9087993 49.47 µM 1.67433812715565 0.0403226019935817 no 229 0.0470320826536646 61 17173644 SGTC_2304 7443016 91.4 µM 1.67385697038083 0.0403665650674766 no 230 0.0470793563167656 68 939854 SGTC_2398 5228213 48.84 µM 1.66668109729492 0.0410268520451394 no 231 0.0477889167724677 106 80771 YMR134W ERG29 SGTC_1868 st057644 42.7 µM 1.66536920862981 0.041148507197917 no 232 0.0479195593000248 87 688665 SGTC_3079 9117512 49.47 µM 1.66153370761185 0.0415058625238018 no 233 0.0483031524639394 73 7185044 SGTC_2710 st078562 53.7235 µM 1.66098782225899 0.0415569267101741 no 234 0.0483579462503761 83 17250908 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.65539178331761 0.0420833421015894 no 235 0.0489225258220424 59 17037758 SGTC_1113 artemisinin 1.17947 µM 1.65246028851852 0.0423612524099646 no 236 0.0492203770611753 117 2240 An anti-malaria and mitochondrial poison. SGTC_724 3910-0327 137 µM 1.64952877663561 0.0426406470955047 no 237 0.0495196763926942 86 2885483 SGTC_2457 5731572 11.68 µM 1.64654861449888 0.0429262037815138 no 238 0.0498254299218441 95 2865357 SGTC_805 3852-0218 479 µM 1.64653713400416 0.0429273068136215 no 239 0.0498266106829463 78 6615355 SGTC_653 0203-0016 55.2 µM 1.64543644433589 0.0430331661583401 no 240 0.0499399195618738 74 295302 SGTC_828 2074-0507 139 µM 1.62882763365135 0.0446562736610818 no 241 0.0516747565265669 81 X828 SGTC_251 melphalan 456.522 µM 1.62828629316588 0.0447099950902129 no 242 0.0517320972478527 98 460612 A DNA alkylator. SGTC_2487 5918373 44.05 µM 1.62769319439354 0.0447689126322437 no 243 0.0517949784418841 103 2876279 SGTC_43 0570-0105 72.5 µM 1.62648397390671 0.0448892284481155 no 244 0.0519233699357691 83 1114046 YDL195W SEC31 SGTC_2822 7994718 71.43 µM 1.62324798863818 0.045212485400506 no 245 0.0522682015349979 92 1018011 SGTC_374 0880-0231 82.3 µM 1.62037012776386 0.0455015387528425 no 246 0.05257639640075 99 6833587 SGTC_2355 9061122 103.12 µM 1.61795375130661 0.0457453864933987 no 247 0.0528362825203231 79 5302957 SGTC_2488 5268135 45.7 µM 1.61385919086304 0.0461609844719681 no 248 0.053278986080369 100 1270356 YLR208W SEC13 SGTC_878 0828-0289 13.7 µM 1.61327754116736 0.0462202671399845 no 249 0.0533421118085177 97 745350 YLR208W SEC13 SGTC_1945 st075991 56.6 µM 1.61064807604423 0.0464890297774763 no 250 0.0536282244567953 92 1084980 SGTC_3320 9137005 35.139 µM 1.60722980599387 0.0468402913378668 no 251 0.0540019829508994 96 4908713 SGTC_1607 st000305 50.6 µM 1.60333071019634 0.0472435582597313 no 252 0.0544308298902952 77 5457690 SGTC_642 0335-0876 158 µM 1.60173144741631 0.047409765914595 no 253 0.0546075039817676 89 6812350 SGTC_1571 st070080 73.4 µM 1.60030818775388 0.0475580756931017 no 254 0.0547651156839969 62 4315245 SGTC_3023 9089636 49.47 µM 1.59324535044433 0.0482995600515429 no 255 0.0555525805834594 71 17249241 SGTC_2654 protoveratrine a 100 µM 1.59099205325267 0.0485380563249782 no 256 0.0558056820981655 85 5702278 A heart drug and vasodilator. SGTC_2719 novobiocin 32.65 µM 1.58949002947699 0.0486975577695245 no 257 0.0559749016486742 71 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1679 SEC14.276 6.7 µM 1.58935206066821 0.0487122298040377 no 258 0.0559904656318634 116 1005053 YMR079W SEC14 SGTC_421 streptovitacin 30 mM 1.58896072388857 0.0487538650061801 no 259 0.0560346301175664 74 91467 include heat shock SGTC_2889 9059656 51.95 µM 1.58865063777889 0.0487868759600641 no 260 0.0560696445299553 90 3949838 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.58844197454912 0.0488090997533459 no 261 0.0560932161488157 93 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1975 st070967 30.8 µM 1.58551282068829 0.0491219256300835 no 262 0.0564249331684573 123 261391 SGTC_3268 9137683 49.47 µM 1.58353132204262 0.0493344510161841 no 263 0.0566502066968856 89 1953228 SGTC_990 3985-0011 41.3 µM 1.57854792948822 0.0498721897136791 no 264 0.0572198931022427 94 5399565 YGL099W LSG1 SGTC_1326 1431-2094 10.8 µM 1.57777694280618 0.049955799947429 no 265 0.0573084313171848 99 616278 SGTC_2228 7354201 200 µM 1.57390238101507 0.0503776735347309 no 266 0.0577550096952975 96 753451 SGTC_168 3970-0862 530.542 µM 1.57214636943026 0.0505698057918255 no 267 0.0579583049105905 153 3135186 SGTC_3256 9138902 49.47 µM 1.56528503308935 0.0513261342361019 no 268 0.0587580454588074 73 17228773 SGTC_731 3966-0296 387 µM 1.56442460261402 0.0514216115707632 no 269 0.0588589433500575 72 660956 SGTC_146 3448-8650 53.125 µM 1.56230038775023 0.0516579291406339 no 270 0.0591086203618778 105 2891488 YIL048W NEO1 SGTC_804 1595-0054 20.9 µM 1.55809171790831 0.0521286904602278 no 271 0.0596057538552573 91 761523 Stimulates phospholipase C. SGTC_1364 1653-0028 37.6 µM 1.55778414181591 0.0521632276090893 no 272 0.0596422132324572 73 5718652 SGTC_1462 k081-0014 26.5 µM 1.55294265625578 0.0527092671510885 no 273 0.0602184174186682 73 3270634 SGTC_1813 st051246 8.6015 µM 1.55233273673111 0.0527783764896518 no 274 0.0602913143542401 79 5291959 SGTC_1181 1222-0449 220 µM 1.53953610801353 0.0542449921459971 no 275 0.0618367349225519 93 658318 SGTC_1057 3448-5381 134 µM 1.53141581254049 0.0551922565811482 no 276 0.0628333292615126 109 5497911 SGTC_3169 9102970 49.47 µM 1.52317700491675 0.0561666515620636 no 277 0.0638572137369845 74 17027839 SGTC_178 4092-0806 87.505 µM 1.52271875147403 0.0562212444082048 no 278 0.0639145422871857 108 2169044 SGTC_381 3461-2219 42.7 µM 1.51988546999606 0.0565597096436143 no 279 0.0642698814430756 95 2883159 SGTC_1075 aripiprazole 15.2 µM 1.51867142197595 0.0567052309280597 no 280 0.0644226117360811 94 60795 An atypical antipschotic. YIL048W NEO1 SGTC_64 000l-0018 272.079 µM 1.51719700433345 0.056882357714036 no 281 0.064608476218564 139 6811119 SGTC_3259 9138485 49.47 µM 1.51439511385726 0.0572201587668408 no 282 0.0649628288967617 74 17646153 SGTC_1336 1486-0901 104 µM 1.51059109480092 0.0576813027357661 no 283 0.0654463321198569 89 5006114 SGTC_333 3486-0131 40.1 µM 1.50499879580267 0.0583645319549123 no 284 0.0661621931664057 100 6744690 SGTC_2987 9018338 71.43 µM 1.50434816480108 0.058444432699614 no 285 0.0662458717448021 118 5055682 SGTC_1328 1441-0025 69.2 µM 1.50185683454506 0.0587511749475091 no 286 0.066567043266643 78 4562601 SGTC_1432 4049-0298 68.4 µM 1.49788036583292 0.0592433894440554 no 287 0.0670821678739602 82 741646 SGTC_3109 9122853 49.47 µM 1.49762858491673 0.0592746638726189 no 288 0.067114887875703 109 1234709 SGTC_382 3229-0966 23.2 µM 1.49697055393799 0.0593564609147089 no 289 0.0672004600787169 99 5722370 SGTC_1860 st056228 74.6 µM 1.49584273237438 0.0594968614250314 no 290 0.0673473213403766 117 688679 SGTC_2243 6634756 200 µM 1.494671953244 0.0596428848758213 no 291 0.0675000387177253 65 885676 SGTC_2526 patulin 37.61 µM 1.4900088854959 0.0602272665232936 no 292 0.0681109498122637 120 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.48994222289593 0.0602356531453135 no 293 0.0681197141588413 89 6710655 SGTC_2206 7254556 146.969 µM 1.48947964806292 0.0602938734820808 no 294 0.0681805543425542 77 4398905 SGTC_504 lovastatin 124 µM 1.48930575481364 0.0603157713250773 no 295 0.0682034365069521 106 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1879 gemcitabine 100 µM 1.4889537944368 0.0603601116632718 no 296 0.068249768204249 94 60750 A nucleoside analog which inhibits DNA replication. SGTC_1390 3413-2614 145 µM 1.48424631618991 0.0609556200865842 no 297 0.0688717932518411 127 3421432 SGTC_2182 6325192 200 µM 1.48420647620443 0.0609606794796083 no 298 0.0688770761167005 90 736248 SGTC_2374 9071832 200 µM 1.48045955305978 0.0614379809543196 no 299 0.0693753235818014 86 17381698 SGTC_995 3931-2021 34.6 µM 1.48031635404673 0.0614562800957282 no 300 0.0693944204162128 101 730143 SGTC_2357 9067248 200 µM 1.48021518089383 0.0614692113951282 no 301 0.0694079151771333 95 9150235 SGTC_2162 5663267 200 µM 1.47984194307696 0.061516934626247 no 302 0.0694577161737782 114 6456493 SGTC_508 roscovitine 141 µM 1.47830039676033 0.0617143476776316 no 303 0.0696636957696853 102 160355 A CDKinase inhibitor. SGTC_727 3032-0951 202 µM 1.4721980547776 0.0625006817506926 no 304 0.070483701280751 84 3652836 SGTC_729 4092-0585 94.1 µM 1.47214685035017 0.0625073127307007 no 305 0.0704906131602897 95 2169061 SGTC_836 0330-0104 1.35 µM 1.47162651064792 0.0625747278998257 no 306 0.0705608812761277 88 46494820 SGTC_48 0382-0018 55 µM 1.46960299852004 0.0628374328675899 no 307 0.0708346538514821 68 762596 SGTC_347 4534-1311 26.2 µM 1.46481980733619 0.0634618328263044 no 308 0.0714850431664073 94 2862016 SGTC_2723 salbutamol 83.58 µM 1.46404886404159 0.0635629224587005 no 309 0.0715902988378304 90 9884233 β2-adrenoceptor agonist SGTC_299 1273-0059 1.44 µM 1.46151632513568 0.0638958826914542 no 310 0.0719368993692499 102 2848077 SGTC_13 0199-0087 65 µM 1.46102553785366 0.0639605645426895 no 311 0.0720042165782883 106 4589825 SGTC_925 2064-1272 59.6 µM 1.45857037907255 0.0642848996278183 no 312 0.0723416956254339 107 6815817 SGTC_1458 k015-0034 6.33 µM 1.45429429505551 0.0648528352868162 no 313 0.072932365731411 81 3598957 SGTC_1553 gossypol 38.6 µM 1.45352433966025 0.0649555108953214 no 314 0.0730391134123544 75 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_734 2023-0417 80 µM 1.45246334163491 0.0650972045080702 no 315 0.0731864075090501 128 3935732 SGTC_438 sphingosine 6.67 µM 1.45231910912652 0.0651164849025417 no 316 0.0732064482644677 78 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2878 9043973 25.97 µM 1.44777944712031 0.065725595400112 no 317 0.0738393712819654 76 6465167 SGTC_2517 totarol 10 µM 1.44530968592463 0.0660588264480834 no 318 0.0741854592189929 87 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2595 hexamethylquercetagetin 100 µM 1.44451291180779 0.0661666095142959 no 319 0.0742973751962443 115 386331 SGTC_2271 7849410 118.62 µM 1.44120817785269 0.066615109853737 no 320 0.0747629393641644 100 972430 SGTC_1137 ixabepilone 100 µM 1.44055642601106 0.0667038391778425 no 321 0.0748550190599231 102 154225 A novel microtubule stabilizer. SGTC_440 fluspirilene 35.1 µM 1.43828074120432 0.067014367618572 no 322 0.0751772070092169 103 3396 An atypical antipsychotic. SGTC_809 3998-0021 90 µM 1.43814266143199 0.0670332452048301 no 323 0.0751967901023214 117 715485 SGTC_37 0566-0070 1.56 µM 1.43488686130053 0.0674795549628445 no 324 0.0756596701514158 103 1626686 SGTC_2936 9038235 15.59 µM 1.43196355881207 0.0678822389528839 no 325 0.076077125325602 115 4749415 SGTC_163 TUB2.036 7.546 µM 1.43195411673275 0.0678835425963803 no 326 0.0760784765141789 139 15992207 YJR013W GPI14 SGTC_2529 gangaleoidin 93.61 µM 1.4289308099337 0.0683019578248926 no 327 0.0765120605027333 83 4565183 SGTC_2796 7949634 45.45 µM 1.42448279817665 0.0689211616545823 no 328 0.0771533805635812 122 2971588 SGTC_2416 tofa 880 nM 1.41917193226863 0.0696661400404753 no 329 0.0779244483665357 94 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2653 dihydrofissinolide 100 µM 1.41788901322586 0.0698470269855618 no 330 0.0781115852690178 93 6857746 SGTC_2713 st079149 53.4 µM 1.41674753394893 0.0700082751223495 no 331 0.0782783770624734 106 3103253 SGTC_1925 st057770 10.1 µM 1.41375182577683 0.0704328182696944 no 332 0.0787173913454029 99 5989122 SGTC_2721 ifenprodil 61.44 µM 1.41347937747203 0.0704715268396556 no 333 0.0787574104047477 99 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_887 0885-0007 9.62 µM 1.40411509549805 0.0718119385846964 no 334 0.0801422895825797 119 5719458 SGTC_2166 5933061 31.504 µM 1.40025468428204 0.0723701798799748 no 335 0.080718532799642 93 2877375 SGTC_2718 lomofungin 53.02 µM 1.39927302366005 0.0725126634647772 no 336 0.0808655629590403 95 5351222 A RNA synthesis inhibitor. SGTC_411 enrofloxacin 100 µM 1.39896052921333 0.0725580656775142 no 337 0.0809124098334757 94 71188 A bacterial gyrase inhibitor. SGTC_105 0111-0055 734.78 µM 1.39879013567824 0.0725828312684772 no 338 0.0809379626116135 99 5179370 SGTC_363 0455-0021 3.06 µM 1.39328988281047 0.0733857395309704 no 339 0.0817660743999693 134 4597466 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.39172745103488 0.0736150524584675 no 340 0.0820024731707141 86 1241132 A phosphatase inhibitor. SGTC_418 lividomycin a 100 µM 1.38946870637471 0.0739475288475475 no 341 0.0823451352037147 107 72394 An antibiotic. SGTC_1134 3477-0009 42.5 µM 1.38931200873178 0.0739706364807753 no 342 0.0823689468974217 125 3973534 SGTC_1673 st016611 27.3 µM 1.3820880705025 0.0750419253415895 no 343 0.0834723304691766 129 5226799 SGTC_1976 st070609 63.5 µM 1.37901549855807 0.0755011492858744 no 344 0.0839449877046338 107 682556 SGTC_261 5-fluorouridine 15.376 µM 1.37556486351148 0.0760194277357149 no 345 0.0844781955782694 98 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2558 carylophyllene oxide 100 µM 1.37255268980273 0.0764740605738784 no 346 0.0849457240743947 106 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2781 5567276 71.43 µM 1.37144714321252 0.0766414406281411 no 347 0.0851178049837961 120 2853274 SGTC_2434 5670830 169.91 µM 1.37005608471976 0.0768524429222404 no 348 0.0853346974722759 119 1549830 SGTC_1980 st071811 45.7 µM 1.36946737566135 0.0769418739682371 no 349 0.0854266130004969 127 4974850 SGTC_1112 tnp00069 1.16933 µM 1.36533335453989 0.0775721044039436 no 350 0.0860741500792095 107 145826 SGTC_880 0833-0487 87.2 µM 1.36053133750237 0.0783090826348569 no 351 0.0868309215543608 118 76075 SGTC_1625 st003711 30.1 µM 1.36042419247276 0.0783255868123034 no 352 0.0868478635404733 105 24207034 YER133W GLC7 SGTC_495 decylubiquinone 155 µM 1.35981696388006 0.0784191716315797 no 353 0.0869439264035294 114 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1426 4048-4480 71.7 µM 1.35952893258088 0.0784635920545367 no 354 0.0869895203684085 106 14224343 SGTC_2035 5154463 94.595 µM 1.35542804032778 0.0790981059142105 no 355 0.0876406104380452 136 2769623 SGTC_33 0986-0033 35.816 µM 1.35465168098743 0.0792186649689277 no 356 0.0877642796624533 79 2848082 SGTC_1055 3448-0672 86 µM 1.35267918071287 0.079525595716809 no 357 0.0880790721790446 121 748378 SGTC_2057 5236571 38.335 µM 1.35266012072441 0.0795285659283095 no 358 0.0880821180752183 111 54684039 YBR257W POP4 SGTC_3066 9117245 49.47 µM 1.34835764760401 0.08020119188116 no 359 0.088771689485289 108 17176980 SGTC_481 bay k-8644 50 µM 1.34800468123005 0.0802565630496717 no 360 0.088828438485541 118 2303 A calcium channel antagonist. SGTC_637 1181-0519 7.26 µM 1.34282530736955 0.0810723967626323 no 361 0.0896642733562318 125 6252091 YGR060W ERG25 SGTC_3312 9133330 71.43 µM 1.34098902983533 0.0813631375634932 no 362 0.0899620071795189 123 17617324 SGTC_2001 4023502 57.655 µM 1.33652260247095 0.082073596387293 no 363 0.0906892589111111 101 108941 YCR052W RSC6 SGTC_2163 5671233 125 µM 1.33352924951668 0.0825523476858768 no 364 0.0911790916946635 132 701023 SGTC_2153 5569715 200 µM 1.32937676592497 0.0832199649319831 no 365 0.0918618496117521 134 2054701 SGTC_1741 st038134 10.228 µM 1.32873905445512 0.0833228518285288 no 366 0.0919670376884911 107 1272587 SGTC_913 3487-1245 167 µM 1.32661147209361 0.0836668027701561 no 367 0.0923186194813557 126 4016153 SGTC_1718 roemerine 11.9335 µM 1.32518682630316 0.0838977105732002 no 368 0.0925545968129092 136 235224 An aporphine alkaloid with mutagenic activity. SGTC_2394 5221648 200 µM 1.32517386828702 0.0838998130135795 no 369 0.0925567452155201 142 788586 SGTC_1248 0469-0687 58.6 µM 1.32463664466612 0.0839870124682251 no 370 0.0926458478534689 122 4017482 SGTC_2219 9098279 200 µM 1.32278743366208 0.0842876874544017 no 371 0.092953038678827 77 902349 SGTC_2816 7982706 58.44 µM 1.32252079092954 0.084331109149888 no 372 0.0929973953979999 129 2981853 SGTC_1575 cyproterone acetate 48 µM 1.32096526517829 0.0845847549171322 no 373 0.0932564731188462 136 9880 An androgen receptor antagonist and liver toxin. SGTC_1618 st003135 44.5 µM 1.3207828201957 0.0846145420550842 no 374 0.0932868948140477 124 1270615 SGTC_3227 9130768 49.47 µM 1.32021700727854 0.0847069703375298 no 375 0.0933812876286855 103 17720899 SGTC_649 1123-0311 367 µM 1.32010077759029 0.0847259663913121 no 376 0.0934006865996403 136 693629 YIL048W NEO1 SGTC_1940 st075990 51.1 µM 1.31956557909043 0.0848134780341022 no 377 0.0934900507297239 120 1084979 SGTC_2227 7312221 64.1025 µM 1.31815820358561 0.0850439249315919 no 378 0.093725346916175 128 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_612 0302-0167 22.4 µM 1.31650992337289 0.0853144144137581 no 379 0.0940014749808767 131 235821 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.31324055384374 0.0858528374260658 no 380 0.0945509513593604 133 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1354 1498-1681 81 µM 1.31270043146969 0.0859420328671044 no 381 0.0946419560864138 124 5754243 SGTC_49 0717-0965 32.132 µM 1.31095283747379 0.08623110452604 no 382 0.0949368489925899 120 5889349 YGL099W LSG1 SGTC_36 0335-0881 14.2 µM 1.30997401272784 0.0863933305367122 no 383 0.0951023135329721 154 23828853 SGTC_2112 5488546 200 µM 1.3094827309882 0.0864748393263821 no 384 0.0951854418199677 130 600757 SGTC_2319 6033012 152.6 µM 1.30728442843827 0.0868402650650414 no 385 0.0955580653427458 124 847246 SGTC_1957 st077035 62.4 µM 1.30354266282115 0.08746491337622 no 386 0.0961947805582203 123 705593 SGTC_2273 7815444 169.05 µM 1.30280358674764 0.0875886899590328 no 387 0.0963209129700774 139 2824616 SGTC_2260 7964312 200 µM 1.30100410005722 0.0878906050173921 no 388 0.0966285256574302 122 231951 SGTC_978 1416-0512 87.4 µM 1.29978802736734 0.0880950748341381 no 389 0.0968368150424104 120 6814003 SGTC_1459 k035-0031 35.7 µM 1.29424058337776 0.0890323194860975 no 390 0.0977911663452907 111 3877128 YMR208W ERG12 SGTC_2436 5633522 8.09 µM 1.29154154207741 0.0894909995407897 no 391 0.0982579798991098 128 5724242 SGTC_2714 st079313 56.9 µM 1.28636195362184 0.0903761469069367 no 392 0.0991583850100816 111 2939799 SGTC_1626 st003712 1.76 µM 1.28552544949793 0.0905197059749142 no 393 0.0993043646755556 150 24207035 SGTC_1313 1220-0047 237 µM 1.28375975837026 0.0908232858505583 no 394 0.0996130139838676 136 3528706 SGTC_1179 1021-1431 9.29 µM 1.28358932212345 0.0908526293313631 no 395 0.0996428439246321 147 2840958 SGTC_741 4582-0002 126 µM 1.28332145374972 0.0908987616141569 no 396 0.0996897397340181 142 2912688 SGTC_2665 lovastatin 100 µM 1.28178963955683 0.0911629045006601 no 397 0.0999582247815918 128 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1310 1188-0297 994 nM 1.28010088886735 0.091454768392218 no 398 0.100254828051874 130 1588352 SGTC_778 3456-2434 196 µM 1.27633571119435 0.0921079900923898 no 399 0.100918435750634 130 5539063 SGTC_1527 coumarin 137 µM 1.27603022010593 0.0921611409404012 no 400 0.100972418287131 143 323 A hepatotoxic, DNA x-linker. SGTC_2694 st077685 81.9 µM 1.27468825619804 0.0923948913995142 no 401 0.101209802586337 119 2838096 SGTC_1693 xanthone 101.9 µM 1.2716930403282 0.09291819597212 no 402 0.101741102180827 152 7020 An insecticide. SGTC_1419 3993-2473 62.6 µM 1.26884232410869 0.093418286662813 no 403 0.102248653196367 133 704026 SGTC_2097 5376186 200 µM 1.25850619095165 0.0952481903730304 no 404 0.104104374825781 130 742755 SGTC_2990 9074105 71.4286 µM 1.25609815681142 0.0956782730302288 no 405 0.104540192166848 131 6502001 SGTC_1692 fluoroquinolonic acid 71 µM 1.25401467825815 0.0960515405259827 no 406 0.104918335163624 127 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_846 0335-0850 148 µM 1.25229695665214 0.096360084901603 no 407 0.105230838713755 133 6819598 SGTC_2675 theaflavin digallate 100 µM 1.25008720333812 0.0967580804814187 no 408 0.10563384692498 135 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3281 9140613 49.47 µM 1.24896785459212 0.0969601448550389 no 409 0.105838415713206 121 16013766 SGTC_2379 9035213 200 µM 1.24859504017818 0.097027513883081 no 410 0.105906613674029 140 646551 SGTC_1927 st060202 13.8 µM 1.24052878612936 0.098493541917293 no 411 0.107389936864102 128 688887 SGTC_1506 4226-2149 212 µM 1.23834412504432 0.0988933772498938 no 412 0.10779424455345 135 991114 SGTC_1999 st074831 12.5 µM 1.23796897065153 0.0989621570835049 no 413 0.107863783244734 148 17112523 SGTC_1259 0671-0132 43 µM 1.23632228814929 0.0992644695162778 no 414 0.108169394782416 128 X1259 SGTC_1150 3909-7983 10.9 µM 1.23244966365877 0.0999781001596162 no 415 0.108890579387174 157 23965914 SGTC_762 1165-0429 115 µM 1.23101818225917 0.100242833572847 no 416 0.109158032002928 143 5967793 SGTC_2794 7785382 27.27 µM 1.23035184205211 0.100366238692168 no 417 0.109282689385955 138 2205081 SGTC_1608 st001473 40.5 µM 1.227757544672 0.100847754421995 no 418 0.109768998709757 173 7292267 SGTC_547 1120-0019 610 nM 1.22448888620928 0.10145683052142 no 419 0.110383928159173 136 3676939 SGTC_1084 voriconazole 435 nM 1.21738590917223 0.102789615177151 no 420 0.111728710848761 149 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_609 0986-0026 86.3 µM 1.21555518157339 0.103135181274591 no 421 0.112077207981152 149 2848610 SGTC_2413 inermin 26.06 µM 1.2132057151344 0.103579899081443 no 422 0.112525589813353 176 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3088 9117578 49.47 µM 1.21260928151487 0.10369301592261 no 423 0.112639619306426 146 678341 SGTC_1695 st026914 34.495 µM 1.20638550979062 0.104878738228355 no 424 0.11383444026457 136 3289191 SGTC_3053 9095903 49.47 µM 1.20205610118969 0.105709325367715 no 425 0.114670896477984 161 17174018 SGTC_2720 fluspirilene 36.88 µM 1.20192818536649 0.105733937848403 no 426 0.114695676588279 131 3396 An atypical antipsychotic. SGTC_1509 1326-1131 80 µM 1.19862599429736 0.106370752066785 no 427 0.115336702966855 124 768313 SGTC_775 4577-0580 57.3 µM 1.1972958738093 0.106628041372154 no 428 0.11559562606746 143 2006902 SGTC_2060 5238662 140 µM 1.19521479522455 0.107031491509445 no 429 0.116001559716628 133 790130 SGTC_2418 pentamidine 31.67 µM 1.19474756409134 0.107122222841536 no 430 0.116092836414397 154 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2140 5586273 200 µM 1.1907839325681 0.107894149860991 no 431 0.116869209056357 129 854421 SGTC_1141 3253-0389 52.6 µM 1.19057613841914 0.107934728513951 no 432 0.116910011824072 149 5402031 SGTC_376 3970-0862 59.1 µM 1.18489682143986 0.109048060422148 no 433 0.118029122153896 165 3135186 SGTC_627 1391-0720 175 µM 1.18416223487134 0.109192664065475 no 434 0.118174424137674 175 997839 SGTC_3166 9102297 49.47 µM 1.18136011460763 0.109745527610914 no 435 0.118729847837566 143 25237072 SGTC_2877 9040724 71.43 µM 1.18104699176238 0.109807431924575 no 436 0.118792028007761 130 6463895 SGTC_3085 9117376 49.47 µM 1.17728282976791 0.1105535681513 no 437 0.119541318906941 157 16480349 SGTC_1498 4478-3555 97.6 µM 1.17702104692503 0.110605593861513 no 438 0.119593552897392 118 3437919 SGTC_335 4077-0256 27.6 µM 1.17578058925773 0.110852356206294 no 439 0.119841282471948 174 3121989 SGTC_694 1315-0438 43.2 µM 1.17259385862085 0.111488095161746 no 440 0.120479356686368 132 6793154 SGTC_75 0159-0059 199.013 µM 1.1706676156251 0.111873635224601 no 441 0.120866203576786 168 5377270 SGTC_2056 5235370 200 µM 1.16069008061604 0.113885913827188 no 442 0.122883978605379 138 5511916 SGTC_872 0588-0139 234 µM 1.15973003644064 0.114080888102566 no 443 0.123079368513223 134 2047100 SGTC_3223 9129970 49.47 µM 1.15700149612517 0.11463632212866 no 444 0.123635874545756 169 17248386 SGTC_2611 pyromycin 23.93 µM 1.15496674369567 0.115051776359509 no 445 0.12405202269143 145 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_86 0417-1630 471.922 µM 1.15465540217953 0.115115440165681 no 446 0.124115784703657 179 3634867 SGTC_2364 9055074 200 µM 1.15314982240428 0.115423657907294 no 447 0.124424447440567 133 6470630 SGTC_733 4069-0007 56.1 µM 1.15081433127939 0.115902932262731 no 448 0.124904313810077 155 5717425 YNL287W SEC21 SGTC_703 3875-0075 71.8 µM 1.14799972295556 0.116482403387746 no 449 0.125484339101062 169 2850814 SGTC_1750 st081859 2.357 µM 1.14544363121612 0.117010429014585 no 450 0.126012716583353 184 5291695 SGTC_3196 9111891 49.47 µM 1.13997039176344 0.118146764470988 no 451 0.127149318293213 154 18891510 SGTC_389 tpck 16.7 µM 1.13953648617376 0.118237183208536 no 452 0.127239729614357 125 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_808 0711-0032 135 µM 1.1361577945909 0.11894292061213 no 453 0.127945265303757 173 4252555 SGTC_2956 9076196 2.52 µM 1.13502561486921 0.119180073163238 no 454 0.128182293056211 163 16423868 SGTC_1499 4480-0877 67.3 µM 1.13230542752799 0.119751222243788 no 455 0.12875302453265 140 2861909 SGTC_298 1391-0729 10 µM 1.13131869765635 0.119958879063744 no 456 0.128960488675953 145 3237558 SGTC_839 0122-0028 230 µM 1.12972884887456 0.120293995693395 no 457 0.129295248616653 205 759448 SGTC_1396 3511-0007 98.6 µM 1.12959846773693 0.120321507342399 no 458 0.129322728479201 162 X1396 SGTC_1581 himbacine 57.9 µM 1.1280155314571 0.120655875423009 no 459 0.129656679948372 152 5281825 An alkaloid muscarinic receptor antagonist. SGTC_975 1335-0046 28.5 µM 1.12631314139221 0.121016205554715 no 460 0.130016498629844 158 16486740 SGTC_515 4092-1064 102 µM 1.12539534867914 0.121210780580515 no 461 0.130210770612179 180 717353 SGTC_1005 4092-0690 4.4 µM 1.12531379483052 0.121228080898796 no 462 0.130228043075748 166 1529343 SGTC_3057 9095946 49.47 µM 1.12328094045278 0.121659879034267 no 463 0.130659097953527 170 24540043 SGTC_1143 3454-2408 5.08 µM 1.11887291140023 0.12259989734738 no 464 0.13159718043593 136 X1143 SGTC_670 4204-0025 119 µM 1.11636536936616 0.123136902260642 no 465 0.132132885386206 146 719039 SGTC_3191 9110352 49.47 µM 1.11586567378875 0.12324411171247 no 466 0.13223981850793 147 17122424 SGTC_1522 st012842 45.6 µM 1.11511202600329 0.123405930181296 no 467 0.132401209334287 161 3491067 YOR116C RPO31 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.11460794424108 0.123514246453023 no 468 0.132509232268422 171 165506 SGTC_1056 3448-1962 115 µM 1.1115759884024 0.124167152980337 no 469 0.133160250649636 159 715507 SGTC_1279 0874-0590 65.2 µM 1.11074873420906 0.124345713807027 no 470 0.133338259379398 152 3523074 SGTC_135 0933-0004 26.348 µM 1.11017526078727 0.124469602011828 no 471 0.133461755548684 163 21230617 YGL099W LSG1 SGTC_293 4049-0273 38.5 µM 1.1072905218587 0.12509410477043 no 472 0.134084170451257 165 1380311 SGTC_1570 verbenone 133 µM 1.10433858511345 0.125735416830576 no 473 0.134723145490935 164 29025 A natural terpanoid with antifungal properties. SGTC_2992 9074591 71.4286 µM 1.1027704390858 0.126077029818187 no 474 0.135063434245387 155 17741321 SGTC_1943 st076331 65.2 µM 1.10208658624914 0.126226206265462 no 475 0.135212015191532 151 24208415 SGTC_2585 alliin 100 µM 1.10103136194353 0.126456635408733 no 476 0.135441503945333 148 87310 A garlic compound which reacts with lipids. SGTC_530 4358-1714 28 µM 1.09993627067732 0.126696080001947 no 477 0.135679945004707 182 1564641 SGTC_3243 9134147 49.47 µM 1.09887814676945 0.126927741332548 no 478 0.135910609924088 164 24282180 SGTC_1642 st009582 77.7 µM 1.09551088561837 0.127666917222294 no 479 0.136646439573999 186 6739311 SGTC_760 0568-0725 82.9 µM 1.09339965430354 0.12813189480294 no 480 0.137109182633219 168 3916171 SGTC_1559 coumarin 343 70.1 µM 1.09337538895165 0.128137245832354 no 481 0.137114507367527 144 108770 A hepatotoxic, DNA x-linker. SGTC_509 pifithrin 175 µM 1.09300362806728 0.128219246468841 no 482 0.137196103403401 181 4817 A p53 inhibitor. SGTC_2916 7875993 68.79 µM 1.09138466312583 0.128576772262955 no 483 0.137551829043915 164 1299250 SGTC_2755 lomerizine 42.69 µM 1.0879768016371 0.12933161024896 no 484 0.138302674429382 141 3949 A calcium channel blocker. SGTC_3285 9112818 20.8695 µM 1.08760487913451 0.129414176216183 no 485 0.138384787936057 194 17017947 YPR165W RHO1 SGTC_1922 5578187 25 µM 1.08100691598875 0.130884982794701 no 486 0.1398470186163 165 1350412 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.07999942528081 0.131110583526951 no 487 0.140071218052047 178 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3229 9132204 49.47 µM 1.0719360220035 0.132925846538124 no 488 0.141874384636916 137 17682924 SGTC_2381 9035592 200 µM 1.07115880381865 0.133101726658423 no 489 0.142049015720787 154 4749657 SGTC_1648 st011736 69.8 µM 1.06569067310297 0.134343661230883 no 490 0.143281747612158 181 2855514 SGTC_1780 st038448 24.544 µM 1.06323211996211 0.134904638669246 no 491 0.14383834979439 164 728868 YDL195W SEC31 SGTC_3015 9080845 49.47 µM 1.06306564977343 0.134942680806788 no 492 0.143876090337766 168 5296973 SGTC_1924 st058459 75.1 µM 1.06297020759739 0.134964494783478 no 493 0.143897731095874 155 688683 SGTC_1389 3405-0187 19 µM 1.06256503903886 0.135057125818223 no 494 0.143989624304913 165 799890 SGTC_1756 st041558 35.5 µM 1.06014918557495 0.13561035153198 no 495 0.144538367159192 174 3955792 SGTC_963 1269-2853 151 µM 1.05754498533009 0.13620844485627 no 496 0.145131467637421 154 3668223 SGTC_3130 9127414 49.47 µM 1.05608496015627 0.136544549913918 no 497 0.145464700486053 169 1494646 SGTC_1122 capsaicin 818.572 nM 1.05608158091085 0.13654532849037 no 498 0.145465472353816 172 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_650 1328-0195 38 µM 1.0558348431483 0.136602184951563 no 499 0.145521838214988 183 2780821 SGTC_3154 9100113 49.47 µM 1.05519264086105 0.136750245288424 no 500 0.145668614591782 165 25237525 SGTC_1147 3809-1045 12.3 µM 1.05513872167715 0.136762681397046 no 501 0.145680942436357 164 325925 SGTC_2875 9039966 71.43 µM 1.05496710120102 0.136802269688869 no 502 0.145720185654716 154 6463691 SGTC_486 niguldipine 82 µM 1.0527185015886 0.13732168569615 no 503 0.146235013246831 170 1236 A calcium channel blocker. SGTC_854 0422-0053 192 µM 1.05155929169306 0.137589983224491 no 504 0.146500896488511 191 3596728 SGTC_2343 7990716 14.84 µM 1.04973074102591 0.138013925680546 no 505 0.146920962955272 174 6456862 SGTC_1175 0741-0056 27.6 µM 1.04832865736144 0.138339596260373 no 506 0.147243605346193 176 765927 SGTC_686 1319-0111 510 µM 1.04735777146924 0.138565416594957 no 507 0.147467300166877 177 4562600 SGTC_2697 mebhydrolin 72.4 µM 1.04648730799602 0.138768092893734 no 508 0.147668050872021 161 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_852 0418-0143 439 µM 1.04603911468227 0.138872527685943 no 509 0.147771486840285 176 5369229 SGTC_1300 1094-0077 113 µM 1.04345532751736 0.13947562673024 no 510 0.148368730164878 175 5532636 SGTC_513 4245-1575 41.7 µM 1.03878267870855 0.140570819266633 no 511 0.149452909428249 195 719745 SGTC_531 3788-1495 174 µM 1.03607431023879 0.141208281905225 no 512 0.150083738058599 160 2896655 SGTC_65 0798-0905 34.986 µM 1.03551462165652 0.14134025853019 no 513 0.150214320779927 167 3602145 SGTC_1524 corynanthine 62.1 µM 1.03549686983378 0.141344445842748 no 514 0.150218463752704 160 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2216 7189485 200 µM 1.03549171744309 0.14134566120807 no 515 0.15021966624711 170 731273 SGTC_2456 5770359 74.46 µM 1.03543226764284 0.141359684963222 no 516 0.150233541445542 190 3118787 SGTC_2601 securinine 100 µM 1.03409254368627 0.141675965740636 no 517 0.150546450855363 222 442872 A GABA receptor antagonist. SGTC_3152 9099253 49.47 µM 1.03296683879746 0.141942091432509 no 518 0.150809708804134 205 25236131 SGTC_2136 5328288 199.296 µM 1.03290185796531 0.141957463749583 no 519 0.150824914606949 145 262395 SGTC_918 glabranin 770.725 nM 1.03222990056778 0.142116492750988 no 520 0.150982215464621 157 124049 Also referred to as licorice root. SGTC_3093 9117344 49.47 µM 1.02989276168619 0.142670551197782 no 521 0.151530174486713 158 24824913 SGTC_1307 1187-1599 12.2 µM 1.02909175962492 0.142860777932718 no 522 0.151718279019066 188 1538471 SGTC_361 000s-0510 1.45 µM 1.02903466972356 0.142874342523557 no 523 0.151731691734354 160 660 SGTC_3347 9188721 44.724 µM 1.02836538456667 0.143033429952192 no 524 0.151888992520493 199 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_700 3453-2283 142 µM 1.02691149012457 0.143379429330483 no 525 0.152231071672859 172 565664 SGTC_1998 st075797 76.8 µM 1.02561436517758 0.143688597178163 no 526 0.152536696772803 175 24208315 SGTC_3202 9113761 49.47 µM 1.02535810997767 0.143749728410348 no 527 0.152597123062963 179 4798415 SGTC_399 oxolinic acid 75 µM 1.02489557984529 0.143860112196248 no 528 0.152706230237206 177 4628 A DNA gyrase inhibitor. SGTC_2754 granisetron 64.02 µM 1.02374893180056 0.144134008694239 no 529 0.152976938480821 201 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2961 9083290 32.55 µM 1.02184894617149 0.144588626302578 no 530 0.153426199584061 173 17741490 SGTC_1170 0310-0127 64.8 µM 1.02081628191358 0.14483612102186 no 531 0.153670744430768 198 774975 SGTC_1 0258-0098 57.368 µM 1.01980358234476 0.145079107770721 no 532 0.153910811940494 172 6790032 YDR047W HEM12 SGTC_1826 st055655 41.6 µM 1.01662217918106 0.145844236473998 no 533 0.154666599531118 165 676168 SGTC_1797 st048695 56.8 µM 1.01559700326752 0.146091368396367 no 534 0.154910666247897 196 592262 YIL048W NEO1 SGTC_812 4251-0442 148 µM 1.01378527605193 0.146528796182536 no 535 0.155342611283778 192 5723007 SGTC_1497 4476-2978 41.3 µM 1.01263383795936 0.146807258616937 no 536 0.155617545435429 167 1528379 SGTC_2546 rhodinyl acetate 100 µM 1.00969789552236 0.147518889219155 no 537 0.156320025521409 185 6708682 SGTC_2838 9002687 71.43 µM 1.0086562779907 0.147771916936678 no 538 0.156569753533554 193 6457060 SGTC_1852 st056254 31.4 µM 1.00723866419757 0.148116747586471 no 539 0.15691004847813 176 442583 SGTC_314 1671-0008 2.74 µM 1.00687709345458 0.148204784789611 no 540 0.156996920532483 196 3913060 SGTC_2278 7948257 134.34 µM 1.00513482252521 0.148629493085929 no 541 0.157415967139493 176 1247028 SGTC_1916 st067606 49.2 µM 1.00358138323492 0.149008855943183 no 542 0.157790215827269 193 19590279 SGTC_879 0831-1030 162 µM 1.00052289483294 0.149757653365169 no 543 0.158528761769579 203 1549252 SGTC_2894 9048625 32.47 µM 0.999508820256717 0.150006478320089 no 544 0.158774134238438 201 4092861 SGTC_1568 digitonin 820 nM 0.999387738781048 0.150036206669467 no 545 0.158803448575232 206 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3272 9137413 49.47 µM 0.997743785685921 0.150440224521484 no 546 0.159201807619536 186 17614870 SGTC_1796 st049173 110.4 µM 0.997072059625945 0.15060551628515 no 547 0.159364766971161 184 94134 SGTC_1501 4491-0275 38.4 µM 0.99673119541767 0.150689439051653 no 548 0.159447501680937 187 5104718 SGTC_1650 st011916 45.8 µM 0.993685529697139 0.151440681831069 no 549 0.160187994846613 195 242528 SGTC_181 1447-1644 8.07 µM 0.993129897075646 0.15157800210843 no 550 0.160323327973744 206 534600 SGTC_2038 4100038 30.985 µM 0.992184157608973 0.151811924546559 no 551 0.160553849582463 194 3596803 SGTC_3279 9140807 49.47 µM 0.99195520337298 0.151868590916361 no 552 0.160609689137062 182 45595718 SGTC_1941 st076221 61.8 µM 0.991659188021576 0.151941875797089 no 553 0.160681902999345 181 2828568 SGTC_1223 0764-0573 147 µM 0.991639823571405 0.151946670696099 no 554 0.160686627755797 165 1609797 SGTC_237 nikkomycin 200 µM 0.991624670189328 0.151950422947963 no 555 0.16069032511175 184 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2059 5238311 157 µM 0.991089924079158 0.152082875182314 no 556 0.16082083629195 188 703021 SGTC_744 1594-0068 283 µM 0.990967739310343 0.15211315010762 no 557 0.160850666655674 202 668392 SGTC_1348 1493-0373 93.8 µM 0.990511149518183 0.152226319283832 no 558 0.160962171107961 208 3010129 SGTC_1539 benzyladenosine 56 µM 0.988973531239412 0.152607840417698 no 559 0.161338046032526 188 92208 A nucleotide analog. SGTC_2094 5332512 191.667 µM 0.98883369776146 0.152642568004704 no 560 0.161372257077995 189 755774 SGTC_2024 5144227 134 µM 0.987307855996519 0.153021850881096 no 561 0.161745870281943 174 3475211 SGTC_1349 flufenamic acid 69 µM 0.98091964884391 0.154616563938442 no 562 0.163316183548934 197 3371 A non-steroidal anti-inflammatory. SGTC_351 caspofungin 25 nM 0.977044720545335 0.155589209999365 no 563 0.164273506522369 200 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1168 k815-0004 80.5 µM 0.974872469950026 0.156136228437839 no 564 0.164811761787106 203 642433 SGTC_269 exalamide 29 µM 0.97044725334793 0.157254506801114 no 565 0.165911802341159 183 3316 A derivative of salicylamide. SGTC_227 fluconazole 33.516 µM 0.970252514719346 0.157303839072378 no 566 0.16596032012031 228 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1919 st067113 52.3 µM 0.964203953107081 0.158841159460305 no 567 0.167471841430764 204 1268243 SGTC_636 0kpi-0074 126 µM 0.963876941205282 0.158924553426326 no 568 0.167553812882885 184 616434 SGTC_2449 5812982 45.77 µM 0.963268175482255 0.159079876137863 no 569 0.167706479860242 172 776185 SGTC_705 1124-0212 310 µM 0.962208867726394 0.159350388801478 no 570 0.167972347780783 232 9554485 SGTC_1100 amiodarone 5.07 µM 0.961469684304423 0.159539330463392 no 571 0.168158030640235 174 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_651 3253-0966 34.4 µM 0.958739445474954 0.160238473593174 no 572 0.168845010806968 192 781462 SGTC_2712 st079126 47.7 µM 0.958416417291955 0.160321324995493 no 573 0.168926409988206 193 3152970 SGTC_1394 3474-0001 65.7 µM 0.957950608407924 0.160440846577382 no 574 0.16904383255071 155 5017666 YIL048W NEO1 SGTC_3102 9121669 49.47 µM 0.954417000927826 0.161349427964714 no 575 0.169936301984468 211 41905072 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.954316313268166 0.161375366430252 no 576 0.169961776456534 228 16725076 SGTC_3046 9092212 49.47 µM 0.949970477516925 0.162497502414577 no 577 0.171063626867857 206 25236637 SGTC_1111 tnp00062 510.699 nM 0.949350222906696 0.162658071106463 no 578 0.171221259014098 187 676306 SGTC_3245 9134821 49.47 µM 0.948276389853753 0.162936304063784 no 579 0.171494383568842 211 17014901 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.947746567655833 0.163073696314545 no 580 0.17162924395387 194 15053 SGTC_1816 st051957 91.6 µM 0.946620151882289 0.163366045967607 no 581 0.171916185720561 192 674121 SGTC_675 1309-0189 238 µM 0.944921881340832 0.163807457853553 no 582 0.172349379748817 185 4246530 SGTC_327 1273-0057 3.96 µM 0.943545257451916 0.164165835359408 no 583 0.172701038857398 194 3108138 SGTC_2643 anethole 100 µM 0.942836991588975 0.164350416698593 no 584 0.172882143726653 209 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3295 9122362 53.5725 µM 0.941503025336341 0.164698427177871 no 585 0.173223569815377 210 4730473 SGTC_787 4152-0075 138 µM 0.93987220732297 0.16512452966885 no 586 0.17364155746047 186 9566539 SGTC_2253 7938677 135.83 µM 0.939710862573304 0.165166724817526 no 587 0.17368294586592 172 2301972 SGTC_2722 naftopidil 47.16 µM 0.939487938665731 0.165225035732465 no 588 0.173740140977985 192 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_886 0866-0150 153 µM 0.938595542087558 0.165458596145883 no 589 0.173969221231898 199 271463 SGTC_1009 4106-0057 9.87 µM 0.93763896402659 0.16570919136189 no 590 0.174214990182301 211 2928005 SGTC_2149 5554786 194.827 µM 0.936940418669357 0.165892344578372 no 591 0.174394603372158 182 745063 YPR165W RHO1 SGTC_776 4476-4378 112 µM 0.936533592164684 0.165999071622843 no 592 0.17449926265759 203 2892008 SGTC_1963 st076565 50.3 µM 0.935181100171059 0.166354203836423 no 593 0.174847488437471 213 4914280 SGTC_419 nsc-638432 893 µM 0.929461263057466 0.167861517009783 no 594 0.176325045697203 200 368090 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.929209630310942 0.167928029518707 no 595 0.176390228778743 217 6728940 SGTC_2337 9009472 200 µM 0.928023070518018 0.168241894005321 no 596 0.176697801258061 183 5742383 SGTC_2905 7799065 20.05 µM 0.927899112401776 0.168274704712991 no 597 0.17672995244309 191 1296806 SGTC_1142 3253-1408 9.78 µM 0.927001139787362 0.168512513674926 no 598 0.176962971249738 207 256655 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.923905321252081 0.169334031048754 no 599 0.177767806170404 225 279621 SGTC_1241 0364-0022 50.8 µM 0.922526145179828 0.169700840411506 no 600 0.178127099583308 211 4563895 SGTC_3241 9133421 49.47 µM 0.921891968698014 0.169869678607929 no 601 0.178292464387872 225 17018221 SGTC_3298 9116858 71.43 µM 0.921693307010167 0.169922590891687 no 602 0.178344286345395 218 2506942 SGTC_2388 9080168 200 µM 0.917969650609627 0.170916317915986 no 603 0.179317377508956 227 15943073 SGTC_2780 5215298 71.43 µM 0.917803649877198 0.170960704704319 no 604 0.179360835542044 222 2834131 SGTC_1880 MG-132 525 µM 0.915793098211358 0.17149888979223 no 605 0.179887712073074 208 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.914791749755035 0.171767334506408 no 606 0.180150483400441 198 4330530 SGTC_3044 9093193 49.47 µM 0.914440416248422 0.171861584688843 no 607 0.180242736521038 213 25236277 SGTC_2098 5376439 882.5 nM 0.911658752824669 0.17260897073034 no 608 0.180974191756367 202 2844116 SGTC_3070 9117005 49.47 µM 0.910416266880082 0.172943474292838 no 609 0.181301511083308 177 8779016 SGTC_223 busulfan 5 mM 0.909573786481696 0.17317052270274 no 610 0.181523664094346 195 2478 A DNA alkylator. SGTC_1343 1487-0095 224 µM 0.90844695874922 0.173474499314984 no 611 0.181821062649648 227 4560101 YGL055W OLE1 SGTC_2836 9010338 19.48 µM 0.906413299191407 0.174023964721855 no 612 0.182358568101956 200 2994051 SGTC_2620 irigenin 100 µM 0.905532396892786 0.174262314846908 no 613 0.182591702425142 216 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1878 temozolomide 1 mM 0.904584621807392 0.174518990621529 no 614 0.182842742661316 197 5394 DNA alkylating agent. SGTC_2986 9022445 71.43 µM 0.904423860020921 0.174562551820367 no 615 0.182885345512825 219 6459286 SGTC_954 1189-0853 2.85 µM 0.902755535002793 0.175015021048898 no 616 0.183327827472144 205 2828194 SGTC_701 4424-0219 185 µM 0.902377454691212 0.175117664175932 no 617 0.183428196629703 210 2911779 SGTC_2006 4011487 200 µM 0.901863337592426 0.175257300500597 no 618 0.183564734486908 206 45595294 SGTC_2768 sulfasalazine 50.2 µM 0.901700440898645 0.175301558640733 no 619 0.183608009369937 196 5384001 An antioxidant and salicylic acid derivative. SGTC_1552 6-methylflavone 10.6 µM 0.901012555089949 0.175488531592429 no 620 0.183790822145227 203 689013 SGTC_2344 7990960 76.95 µM 0.901012545951892 0.175488534077066 no 621 0.183790824574513 224 140813 SGTC_579 4491-1009 110 µM 0.898976977946661 0.176042558113861 no 622 0.1843324617315 253 1271041 SGTC_265 mycophenolic acid 32.932 µM 0.898635178865208 0.176135694621786 no 623 0.184423507139026 194 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1987 st072290 61.9 µM 0.898369284265573 0.17620816955492 no 624 0.184494353126076 212 54697379 SGTC_1312 1218-2183 165 µM 0.89714905485479 0.17654100968258 no 625 0.184819692821502 209 6744073 SGTC_2013 4024628 200 µM 0.895696801175781 0.176937656584146 no 626 0.18520735965988 222 5230760 SGTC_488 nitrendipine 139 µM 0.895322753039189 0.177039909647297 no 627 0.185307290373474 200 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3193 9111931 49.47 µM 0.893942467586874 0.17741755952115 no 628 0.185676337113773 228 17087244 SGTC_1070 indatraline 8.81 µM 0.891323785479542 0.17813543461362 no 629 0.186377745937068 222 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2733 amorolfine 100 µM 0.889395302890623 0.178665270186332 no 630 0.186895334230038 239 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_109 0132-0036 33.701 µM 0.88801756539676 0.179044399877236 no 631 0.187265651388179 190 67274 A color developer. SGTC_3145 9085516 49.47 µM 0.886835241839304 0.179370158278211 no 632 0.187583805387859 205 25236195 SGTC_1555 citronellol 128 µM 0.886468826662171 0.179471190011196 no 633 0.187682472591202 215 8842 A terpine precursor. SGTC_1604 st002052 72.4 µM 0.886071890412285 0.179580677683593 no 634 0.187789394589349 203 6254834 YHR062C RPP1 SGTC_1845 st056753 3.01 µM 0.881942162611464 0.180722277413189 no 635 0.188904042519182 220 5375839 SGTC_352 k048-0007 5.11 µM 0.878279577832799 0.181738540851428 no 636 0.189896007861685 242 6811911 SGTC_3067 9117431 49.47 µM 0.877386017689493 0.181987019960847 no 637 0.190138502571058 244 17150885 SGTC_3273 9137859 49.47 µM 0.877080509358985 0.182072023709586 no 638 0.190221455175449 237 2377234 SGTC_1647 st011722 22.4 µM 0.876165544799795 0.18232674924516 no 639 0.190470022274233 208 2854783 SGTC_1236 0330-0013 258 µM 0.875937926994811 0.182390152465512 no 640 0.190531889840516 211 4617066 SGTC_2873 9040596 71.43 µM 0.875291170349824 0.182570382492033 no 641 0.190707748594604 228 6463863 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.874849269788988 0.18269358973287 no 642 0.190827962463965 209 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2943 9068529 45.32 µM 0.872522170328117 0.183343269507793 no 643 0.191461789402248 249 3270634 SGTC_1885 st057546 99.9 µM 0.871987992781443 0.183492604267685 no 644 0.191607463987858 198 702008 SGTC_164 4100-3994 89.624 µM 0.871261162450758 0.183695918793284 no 645 0.191805785562346 236 4615967 SGTC_2445 5742597 35.57 µM 0.869953035571508 0.184062191488282 no 646 0.192163035134397 238 1774255 SGTC_2872 9044037 25.97 µM 0.869610621096711 0.184158141831412 no 647 0.192256615741136 210 6465195 SGTC_429 1112-0049 25.5 µM 0.869455556285593 0.18420160386122 no 648 0.192299003547544 206 2836170 SGTC_156 3474-0145 5.642 µM 0.868721617652424 0.184407400982321 no 649 0.19249970718799 203 2265471 SGTC_2760 etidronate 98.04 µM 0.867387764760752 0.184781780679672 no 650 0.192864791719281 203 3305 A chelator and antioxidant. SGTC_2572 astragaloside iv 100 µM 0.866563697704046 0.185013311969693 no 651 0.193090555651713 223 45006101 An anti-inflammatory agent. SGTC_3097 9117246 49.47 µM 0.864035215019495 0.185724843077591 no 652 0.1937842729301 216 16423892 SGTC_510 ag-490 170 µM 0.86347175664576 0.185883634842429 no 653 0.193939070750526 210 5328779 SGTC_1683 st010134 710 nM 0.86295959245614 0.186028044091378 no 654 0.19407984197766 200 3818134 SGTC_2513 baicalein 25.65 µM 0.862835609886668 0.186063012533186 no 655 0.194113928644925 217 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_290 2043-6722 48.1 µM 0.862826622070152 0.186065547644193 no 656 0.19411639981719 215 773758 YLR208W SEC13 SGTC_948 3448-0295 75.3 µM 0.859996896954263 0.186864766615531 no 657 0.194895376508977 211 678569 SGTC_2704 st078022 71.1 µM 0.859764259336464 0.186930566450881 no 658 0.194959502266478 212 54697681 SGTC_1558 st069300 45.6 µM 0.859180544790307 0.187095728911761 no 659 0.195120457637934 220 24208000 SGTC_2030 5175110 200 µM 0.857694624586208 0.187516578308402 no 660 0.195530554517976 215 2831986 SGTC_2662 daunorubicin 22.37 µM 0.855466309635813 0.188148787715434 no 661 0.196146523934984 218 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1250 0485-0349 40.2 µM 0.855328854311969 0.18818782906576 no 662 0.196184558977329 211 6842794 YDL195W SEC31 SGTC_2830 7992007 71.43 µM 0.854844537645423 0.188325429061883 no 663 0.19631860910242 223 1952075 SGTC_1518 st038567 90.8 µM 0.85435178251257 0.188465490205106 no 664 0.196455051812369 242 77966 SGTC_558 k064-0027 21.3 µM 0.852690236489419 0.188938242812918 no 665 0.196915553336723 219 5088526 SGTC_2656 pseudo-anisatin 100 µM 0.85040736901878 0.189588967628606 no 666 0.197549320299132 249 6708809 A neurotoxin. SGTC_2621 lithochol-11-enic acid 100 µM 0.850048423568926 0.18969140929615 no 667 0.197649082379428 222 6708711 SGTC_2957 9076800 11.52 µM 0.849670490101168 0.189799306859918 no 668 0.197754154721586 215 16459615 SGTC_905 2-aminofluorene 215 µM 0.84827291286567 0.190198633858296 no 669 0.198142999578836 229 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1436 4092-1007 8.32 µM 0.847354024174713 0.190461467174749 no 670 0.198398911317318 193 2881121 SGTC_851 0394-0702 453 µM 0.842979024547845 0.191715921607377 no 671 0.19962008746097 240 762646 SGTC_2138 5575593 77.673 µM 0.840956992738578 0.192297409451115 no 672 0.200186014115663 225 762213 SGTC_779 1360-0071 233 µM 0.838851475566783 0.192904050727037 no 673 0.200776330273646 237 7566 SGTC_106 0092-0003 11.579 µM 0.83796869303644 0.193158745293553 no 674 0.201024143317808 214 1072148 SGTC_1139 k015-0024 46.9 µM 0.837600492888086 0.193265036598694 no 675 0.201127557966763 235 2766652 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.837577768503452 0.193271597799338 no 676 0.201133941503248 229 688664 SGTC_3186 9110464 49.47 µM 0.836837391073475 0.193485440978482 no 677 0.201341988352436 216 17018021 SGTC_125 0133-0007 11.75 µM 0.835903117619782 0.19375549302321 no 678 0.201604704201696 231 26541 SGTC_2405 ticlatone 3.52 µM 0.835311391665405 0.193926650398399 no 679 0.201771202540662 193 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_794 k038-0031 316 µM 0.832349647019172 0.194784722223316 no 680 0.202605807465622 220 6624242 SGTC_2075 5212009 200 µM 0.830001073384984 0.195466786152158 no 681 0.203269088388191 232 780898 SGTC_945 3381-0768 11.3 µM 0.827383502507122 0.196228678142663 no 682 0.2040098641354 240 1126236 YIL048W NEO1 SGTC_1211 1056-0033 32.3 µM 0.827347757898222 0.196239094713006 no 683 0.204019991022557 217 6741922 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.827135098475281 0.196301074117204 no 684 0.204080246242618 241 1273210 SGTC_2251 lansoprazole 556 µM 0.825886007035625 0.196665360236222 no 685 0.204434379514676 209 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1061 3448-9325 110 µM 0.825663985688747 0.196730153571305 no 686 0.204497363647088 248 723482 SGTC_666 0272-0154 136 µM 0.82415762775263 0.197170101082447 no 687 0.204924999734381 231 6870312 SGTC_359 0081-0058 15.9 µM 0.822681401892194 0.197601825248542 no 688 0.205344597102562 232 3494159 SGTC_141 0443-0274 32.331 µM 0.822130693668926 0.197763026816154 no 689 0.205501259121233 209 1627241 SGTC_2895 9054447 58.44 µM 0.819491590923121 0.198536638855159 no 690 0.206252998862879 244 2697450 SGTC_2626 ethyl orsellinate 100 µM 0.81894911493879 0.198695883162528 no 691 0.206407723079622 244 75653 A natural product. SGTC_407 eburnamonine 100 µM 0.817816432732587 0.199028631235995 no 692 0.206731006693592 218 3195 SGTC_2193 5925765 200 µM 0.81593509454986 0.199582053431389 no 693 0.207268629393611 218 877370 SGTC_737 1950-0117 57.9 µM 0.814844283121176 0.199903354730203 no 694 0.207580724636254 231 5393513 SGTC_2627 acetyl isogambogic acid 100 µM 0.813973364570187 0.200160109204515 no 695 0.207830104938707 231 6857789 A caspase activator and apoptosis inducer. SGTC_1779 st039427 55 µM 0.812344553090066 0.200640828849245 no 696 0.208296976204578 233 1124498 SGTC_397 arbidol 50 µM 0.811927962873823 0.200763890519186 no 697 0.208416484030409 225 131410 A RNA synthesis inhibitor. SGTC_264 promethazine 12.5 mM 0.810084374678344 0.201309034171236 no 698 0.208945842041912 255 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1472 k841-0093 193 µM 0.809084172956486 0.201605161842431 no 699 0.209233365682424 236 X1472 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.808486604982557 0.201782207026612 no 700 0.209405257033972 220 688664 SGTC_1831 st055328 12 µM 0.805173546850519 0.202765475236807 no 701 0.210359769659316 233 1103068 SGTC_1504 k297-0033 30 µM 0.805057789558794 0.202799882023792 no 702 0.210393166173656 184 4388117 SGTC_3049 9092223 49.47 µM 0.80383613785239 0.203163208779001 no 703 0.210745808063606 228 8623917 SGTC_608 k048-0125 159 µM 0.8036375561787 0.203222304887078 no 704 0.210803163376347 236 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2165 5727197 32.143 µM 0.803471832084293 0.203271630730257 no 705 0.210851035612572 238 1361712 SGTC_2975 9084847 53.72 µM 0.802452093714256 0.203575301173011 no 706 0.211145744741971 221 27211724 SGTC_1197 1601-0112 267 µM 0.801130196413761 0.203969354708606 no 707 0.211528138268723 249 7350313 SGTC_445 e6 berbamine 66 µM 0.799878504409936 0.204342898861497 no 708 0.21189059653998 250 6610268 A calcium/calmodulin antagonist. SGTC_1002 4049-0206 172 µM 0.797585150173363 0.205028363473856 no 709 0.212555635668296 247 4662749 SGTC_1523 st012844 44.7 µM 0.797062586711504 0.205184744355114 no 710 0.212707341787279 206 4274103 SGTC_2635 hydroquinidine 100 µM 0.79684205430845 0.205250761526419 no 711 0.21277138381828 225 442912 An experimental heart treatment. SGTC_772 k072-0172 35.3 µM 0.796808433373107 0.205260827183293 no 712 0.212781148238417 223 5861980 SGTC_1588 farnesol 29.9 µM 0.793556930425671 0.206235668497015 no 713 0.213726707127622 230 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2842 9000675 19.48 µM 0.792485993595569 0.206557348608772 no 714 0.214038677747401 246 2989072 SGTC_1956 st077085 54 µM 0.78915555963672 0.207559617213821 no 715 0.215010546177932 263 24208685 SGTC_1227 3909-8010 46.6 µM 0.785793783588625 0.208574226848335 no 716 0.215994154536009 216 15982272 SGTC_706 4262-0057 46.9 µM 0.785611960879628 0.208629185550843 no 717 0.216047427504804 239 883298 SGTC_1405 3909-7894 12 µM 0.784585587263314 0.208939582785405 no 718 0.216348291558938 242 7104060 SGTC_2846 9008642 19.48 µM 0.78383723580939 0.209166071582139 no 719 0.216567810915766 270 2992898 SGTC_1815 st051655 58.2 µM 0.783654147045841 0.209221505452491 no 720 0.216621537283153 245 5984156 SGTC_3156 9099931 49.47 µM 0.781717720430635 0.209808327486905 no 721 0.217190242582993 248 18111053 SGTC_2696 st077691 74.316 µM 0.779064123511269 0.210614052996868 no 722 0.217970971258717 254 757133 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.778727691949319 0.210716334995731 no 723 0.218070070005352 246 75037 A free radical scavenger. SGTC_1474 0330-0125 5.35 µM 0.778678563385072 0.210731273510669 no 724 0.218084543410078 245 X1474 SGTC_307 1501-1223 22.3 µM 0.778139426743094 0.21089524951793 no 725 0.21824341086364 237 2830329 SGTC_1232 0279-0259 161 µM 0.777764650560823 0.211009280092068 no 726 0.218353885479934 238 1560000 SGTC_2817 7995342 71.43 µM 0.777440446085973 0.211107952711027 no 727 0.218449478806845 246 18879975 SGTC_262 fenpropimorph 62.5 µM 0.777197883931231 0.211181794923244 no 728 0.218521015242497 261 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_346 4513-0042 7.16 µM 0.776788557625113 0.211306438783824 no 729 0.218641764347906 231 2827372 SGTC_2913 7966556 36.57 µM 0.776215210772856 0.211481100943957 no 730 0.218810963211983 235 2976516 SGTC_441 propafenone 146 µM 0.775946765580029 0.21156290809462 no 731 0.218890209247387 266 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2119 5528445 120.635 µM 0.775557458912736 0.211681580005257 no 732 0.219005163376934 229 791935 SGTC_2349 9023730 187.07 µM 0.775269723027603 0.211769315243353 no 733 0.219090148085472 248 4126287 SGTC_1876 myriocin 605 nM 0.772917119115169 0.212487459364232 no 734 0.219785716312001 267 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2145 5634607 200 µM 0.770706086498632 0.213163683177624 no 735 0.220440581727508 241 308662 SGTC_2642 cholecalciferol 100 µM 0.769778107974709 0.213447870329137 no 736 0.220715763975523 241 9821465 A vitamin D precursor, similar to steriods. SGTC_1930 st074634 34.3 µM 0.767475936497434 0.214153847516095 no 737 0.221399297500433 244 684253 YOR116C RPO31 SGTC_1684 st024538 14.6195 µM 0.767284010797002 0.21421276418457 no 738 0.221456336416586 242 6732859 SGTC_3005 9076496 71.4286 µM 0.767176670622899 0.214245719200698 no 739 0.221488240795087 247 21368410 SGTC_2301 7769476 200 µM 0.765281910848199 0.21482792374683 no 740 0.222051846602186 238 977820 SGTC_2373 9071805 200 µM 0.764801912463136 0.214975559065233 no 741 0.222194754398169 260 10149009 SGTC_1357 1503-1303 39.5 µM 0.763142424124775 0.2154864293193 no 742 0.222689230729459 232 292895 SGTC_1753 st043925 64 µM 0.761136060967273 0.216105023666883 no 743 0.223287901773332 246 670181 SGTC_1948 st076329 66.6 µM 0.76004526509838 0.216441764872408 no 744 0.223613764181451 242 24208413 SGTC_3033 9090887 49.47 µM 0.758328529787173 0.216972355327336 no 745 0.224127165960392 246 19325384 SGTC_630 4356-0227 183 µM 0.757716806665212 0.217161601772644 no 746 0.224310267716467 265 779312 SGTC_2404 5161160 200 µM 0.755595734946545 0.217818527708284 no 747 0.224945806932833 267 2831543 SGTC_1540 guanosine 70.6 µM 0.754907332466025 0.218031981821807 no 748 0.225152292947882 252 6802 Guanosine is a purine nucleoside SGTC_2864 9034755 47.6 µM 0.754708177144612 0.218093756729059 no 749 0.225212049516668 244 4930451 SGTC_962 1254-0300 21.5 µM 0.753649322647096 0.218422366417265 no 750 0.225529909694363 225 7340576 SGTC_1827 berberine 7.24 µM 0.753483778038003 0.218473768043995 no 751 0.225579627885911 227 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1288 0973-0013 65.5 µM 0.749736053787257 0.219639299564438 no 752 0.226706844328518 238 4315430 SGTC_2563 tomatine 8.54 µM 0.748211082908712 0.220114581309698 no 753 0.227166423540388 261 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2111 5486399 200 µM 0.74782833905054 0.220233962144389 no 754 0.227281853127416 239 689674 SGTC_1207 2099-0101 141 µM 0.746707570854847 0.220583752059879 no 755 0.2276200493826 260 5837381 SGTC_1089 terbinafine 2.25 µM 0.745880721814761 0.220842014194578 no 756 0.227869735879097 248 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_154 3389-1638 511.116 µM 0.745129796827671 0.221076711775475 no 757 0.228096628795724 261 5238686 SGTC_1752 st044819 83.042 µM 0.744853013442729 0.221163254925948 no 758 0.228180291272008 247 441209 YML126C ERG13 SGTC_1710 st031758 61.5 µM 0.742663212726377 0.221848633038462 no 759 0.228842803578617 258 5394341 SGTC_1651 st011928 86.1 µM 0.741999004187635 0.222056760897014 no 760 0.229043969467558 248 720198 SGTC_2157 5649910 96.377 µM 0.741709352784607 0.222147557232389 no 761 0.229131725955438 250 2858091 SGTC_1557 sumaresinolic acid 42.3 µM 0.740873959831417 0.222409544521565 no 762 0.229384932873044 247 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_24 0417-1663 219 µM 0.739393648966008 0.222874216830333 no 763 0.229833998837091 277 4329390 SGTC_3092 9117248 49.47 µM 0.73932499172866 0.222895781876526 no 764 0.22985483858072 276 17141857 SGTC_3337 9144342 33.5465 µM 0.738188741172515 0.2232528475799 no 765 0.230199881814141 242 17682949 SGTC_1703 st026983 48.3 µM 0.737489424224605 0.22347276904748 no 766 0.230412386124348 266 1104023 SGTC_1404 3909-7820 48.3 µM 0.736569593839037 0.223762225240027 no 767 0.230692065676627 249 23741373 SGTC_2327 6189656 200 µM 0.736566140213783 0.223763312443182 no 768 0.230693116127876 263 5349088 SGTC_2286 7945697 125 µM 0.735796778114166 0.224005582895379 no 769 0.230927191136703 251 1245733 SGTC_2729 fluphenazine 10.66 µM 0.735400264158026 0.224130502448874 no 770 0.231047880513437 271 3372 An atypical antipsychotic. SGTC_365 0121-0052 13.6 µM 0.735000717080512 0.224256417581347 no 771 0.231169528702466 221 3101739 SGTC_2516 gossypol 71.55 µM 0.733064318998258 0.224867231820801 no 772 0.231759600602341 263 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1266 0828-0227 32.9 µM 0.732660009325825 0.224994885521161 no 773 0.231882910303708 265 3913820 SGTC_2883 9059145 45.46 µM 0.727041135081019 0.226773192641917 no 774 0.233600378546712 278 16476510 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.725418678085821 0.227288152754265 no 775 0.234097608906508 280 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2232 chlorophetanol 41.5365 µM 0.724791120192582 0.227487513226659 no 776 0.234290092097141 264 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.723669053411297 0.227844212963527 no 777 0.234634468218704 246 803109 SGTC_747 3448-8087 38.7 µM 0.723477197938175 0.227905234404856 no 778 0.234693379038787 271 5168703 SGTC_693 4161-2696 114 µM 0.723163243256922 0.228005110481526 no 779 0.234789799076716 277 805759 SGTC_2077 5212015 200 µM 0.722936539735393 0.228077245297566 no 780 0.23485943663026 257 780900 SGTC_270 tamoxifen 5.46 µM 0.722533983972569 0.228205366178835 no 781 0.234983119645344 284 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1729 st035615 45.989 µM 0.722025079166013 0.228367392519358 no 782 0.23513952930353 271 17385451 SGTC_3288 9119690 36.221 µM 0.722022624466837 0.22836817420904 no 783 0.235140283883862 279 17595618 YKL019W RAM2 SGTC_102 gallobenzophenone 83.616 µM 0.720858600025581 0.228739022770555 no 784 0.235498258395362 254 70837 SGTC_2315 7733312 200 µM 0.718258065938421 0.229568751648629 no 785 0.236299090529451 261 726316 SGTC_1824 st053723 68.6 µM 0.717681367091041 0.22975298190146 no 786 0.23647688734367 266 675225 SGTC_2018 5133068 143 µM 0.717419762074992 0.229836580639432 no 787 0.236557564692557 281 785362 SGTC_2332 7982454 138.89 µM 0.715965303446539 0.230301679196444 no 788 0.237006386688858 288 2981748 SGTC_2700 st077718 96.8 µM 0.71585335681335 0.230337498658603 no 789 0.237040950964418 254 904970 SGTC_3316 9136639 10.545 µM 0.715530136774494 0.230440936559371 no 790 0.237140762868201 255 4903665 SGTC_2037 5169046 200 µM 0.711882271631023 0.231610136539636 no 791 0.238268840559633 252 5718022 SGTC_1085 doxorubicin 7.67 µM 0.710762173463291 0.23196980854327 no 792 0.238615812321605 273 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3232 9132874 49.47 µM 0.710456770006401 0.232067929839888 no 793 0.238710464819309 244 3784940 SGTC_2462 5162487 171.77 µM 0.709950793772092 0.232230542833106 no 794 0.238867325253535 256 2259986 SGTC_1018 4259-0013 28.1 µM 0.709807922643799 0.232276470897183 no 795 0.238911627710521 266 6801262 SGTC_781 4335-2806 94.4 µM 0.709757500772662 0.232292680969315 no 796 0.238927263941966 278 845254 SGTC_928 2764-0428 58.7 µM 0.709438737664887 0.232395174337611 no 797 0.239026127919132 274 662578 SGTC_2998 9066762 71.4286 µM 0.708028813595652 0.232848815261963 no 798 0.239463682202132 265 4945196 SGTC_1833 st055984 71 µM 0.707706177617403 0.232952692024935 no 799 0.239563870155376 258 676288 SGTC_2940 9060638 45.86 µM 0.7062262552293 0.233429501548719 no 800 0.240023722629895 255 4027022 SGTC_2655 perillic acid 100 µM 0.704661726652857 0.233934158123141 no 801 0.240510387450071 271 5702197 An apoptosis inducer. SGTC_3267 9137951 49.47 µM 0.70432127420519 0.234044054975114 no 802 0.240616360285177 290 16643986 SGTC_300 r073-0011 5.04 µM 0.704308794903384 0.234048083793022 no 803 0.240620245207732 268 2735780 SGTC_1681 tripelennamine 100 µM 0.703460491678007 0.234322040047967 no 804 0.240884409916409 249 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1116 jasmonic acid  1.58368 µM 0.699923957667087 0.235466060153804 no 805 0.241987397372572 278 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2805 7950783 58.44 µM 0.697693092807806 0.236189296618167 no 806 0.242684574357067 266 1178958 YDL195W SEC31 SGTC_1430 4049-0248 69.1 µM 0.696637771585164 0.236531852895104 no 807 0.243014755723594 278 22774488 SGTC_2521 angolensin 13.4 µM 0.696007253656602 0.236736648820292 no 808 0.243212143564314 284 821428 A flavenoid. SGTC_1230 0170-0365 3.77 µM 0.695144522994572 0.237017026748455 no 809 0.243482367522508 265 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_158 k038-0087 26.446 µM 0.694112295089242 0.237352729074247 no 810 0.243805894301883 254 X158 SGTC_1548 st061468 90.8 µM 0.693808371535133 0.237451621166679 no 811 0.243901195958695 270 390799 SGTC_263 alizarin 107.927 µM 0.69284364171683 0.237765679346731 no 812 0.24420384052003 287 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1414 3917-0015 5.4 µM 0.692027823161231 0.23803143865154 no 813 0.244459928178684 268 6618702 SGTC_2109 5483026 200 µM 0.691137097586699 0.238321785341251 no 814 0.24473969449851 304 759335 SGTC_1478 0453-0656 35.7 µM 0.689341996098753 0.238907517203047 no 815 0.245304037891508 288 5258496 SGTC_2765 myclobutanil 7.74 µM 0.689261782521115 0.2389337088198 no 816 0.245329271725611 297 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3296 9122258 64.045 µM 0.688062906961204 0.239325356890122 no 817 0.245706583897084 265 4730474 SGTC_2929 9013348 24.6 µM 0.687524942454837 0.239501212785507 no 818 0.245875994234438 274 2995952 SGTC_1730 st033808 45.1 µM 0.687390823337263 0.23954506613772 no 819 0.245918239430228 286 1045166 SGTC_2762 leflunomide 42.06 µM 0.686405081617775 0.239867511697851 no 820 0.246228850459409 291 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_657 3534-0529 86.7 µM 0.686127378459368 0.239958393787125 no 821 0.246316393762512 277 1049549 SGTC_310 1273-0058 1.06 µM 0.683382497232573 0.240857702343114 no 822 0.247182588472567 246 2734232 SGTC_2927 9011802 47.9 µM 0.68131367442444 0.241536723057185 no 823 0.247836516273441 267 43912568 SGTC_1008 4106-0037 6 µM 0.679054422724736 0.242279431470725 no 824 0.248551689732719 291 2905394 SGTC_2857 9024691 58.44 µM 0.678079840012829 0.242600198369697 no 825 0.248860536162128 299 16478292 SGTC_1636 st007707 68.9 µM 0.674329493670202 0.24383670176272 no 826 0.250050928521744 296 403051 SGTC_676 falcarinol 140 µM 0.673694211040346 0.244046493216633 no 827 0.250252871516889 301 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_76 0433-0009 400.328 µM 0.673693165781088 0.244046838476213 no 828 0.250253203854084 304 2841569 SGTC_20 0481-0013 4.944 µM 0.672226644818203 0.244531504402047 no 829 0.250719710414624 281 182045 SGTC_1131 3454-3128 32.3 µM 0.67200457745553 0.244604939924089 no 830 0.250790391113805 270 710982 SGTC_3198 9112019 49.47 µM 0.671819712777838 0.244666081937368 no 831 0.25084923880413 315 45595555 SGTC_1849 st056239 19.2 µM 0.671179675295676 0.244877831038703 no 832 0.251053037409655 275 5393181 SGTC_726 3448-4391 34.2 µM 0.670520795991885 0.245095916723582 no 833 0.251262927036207 287 1356692 SGTC_2552 juarezic acid 87.02 µM 0.67011672027996 0.245229715380695 no 834 0.251391693462009 270 1549512 SGTC_2002 4023503 131 µM 0.66992107804301 0.245294511081538 no 835 0.251454051119108 304 4736863 YCR052W RSC6 SGTC_180 1486-1293 102.781 µM 0.669734345447477 0.245356364538243 no 836 0.251513576602154 275 4140536 SGTC_3147 9097027 49.47 µM 0.669093079312696 0.245568841863855 no 837 0.251718052202734 307 25236841 SGTC_475 α-linolenic acid 10 µM 0.66850529032446 0.245763686840466 no 838 0.251905553038718 271 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_626 0214-0009 33 µM 0.667117128406114 0.246224175093389 no 839 0.252348660052409 287 3437874 SGTC_3034 9090421 49.47 µM 0.667046220029702 0.246247709600068 no 840 0.252371305323702 264 17173761 SGTC_2079 5212404 121 µM 0.666843216432302 0.24631509320996 no 841 0.252436142395624 266 758462 SGTC_3009 9080819 71.4286 µM 0.665000612678362 0.246927166128015 no 842 0.253025050601383 281 17027216 SGTC_1546 5-methoxyflavanone 78.7 µM 0.664308120195168 0.2471574073378 no 843 0.253246562459958 264 147795 SGTC_2885 9057732 51.95 µM 0.664174756112622 0.247201761661736 no 844 0.253289234161503 292 6471414 SGTC_433 pimozide 108 µM 0.661326290640716 0.248150121895869 no 845 0.25420154233857 284 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_216 k038-0035 28.382 µM 0.6608378009888 0.248312952998931 no 846 0.254358168998836 284 4444231 YPR107C YTH1 SGTC_1464 k208-0027 110 µM 0.659834750241355 0.248647484239835 no 847 0.254679940228785 280 X1464 SGTC_821 1114-0266 29.2 µM 0.659826999724809 0.248650070078124 no 848 0.254682427366575 276 3123235 SGTC_2159 5658611 73.75 µM 0.659675991387897 0.248700454499401 no 849 0.254730888422024 292 793844 SGTC_357 1325-0123 420 µM 0.658560878785374 0.249072683690958 no 850 0.25508889578364 296 1098503 SGTC_3294 9122953 26.2835 µM 0.657054384884665 0.249576027874747 no 851 0.255572973895973 291 16459826 SGTC_1293 1000-1278 195 µM 0.656721141600355 0.249687442836362 no 852 0.255680118943855 304 678847 SGTC_2458 5808907 16.39 µM 0.65578452690572 0.250000727503389 no 853 0.255981386734974 299 2731747 SGTC_3220 9131269 49.47 µM 0.655705316303568 0.250027231917322 no 854 0.256006873796212 289 17722206 SGTC_1905 st060207 84.5 µM 0.655689514091708 0.250032519624805 no 855 0.25601195852574 269 1948547 SGTC_568 1193-0097 7.48 µM 0.654971245143235 0.250272928106363 no 856 0.256243133891182 265 3646150 SGTC_2677 mitomycin C 100 µM 0.654968441726601 0.250273866665054 no 857 0.256244036385954 301 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2468 5987765 72.9 µM 0.654100537562423 0.250564522880116 no 858 0.256523517591839 272 26772094 SGTC_1135 dihydrocapsaicin 536.708 nM 0.653078257432651 0.250907107979845 no 859 0.256852914267101 308 107982 A Capsaicinoid. SGTC_2152 5568786 200 µM 0.652262964429747 0.251180505441437 no 860 0.257115773735613 295 5399883 SGTC_2276 7947513 42.08 µM 0.65204843217438 0.251252472101453 no 861 0.257184964544899 286 2105100 SGTC_616 4092-0450 108 µM 0.650802186086332 0.251670751438116 no 862 0.257587094434603 313 787165 SGTC_2233 sulbentine 40.3845 µM 0.649477397208093 0.25211579515231 no 863 0.258014925725952 277 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1846 st056244 14.8 µM 0.649416627295903 0.252136219881292 no 864 0.258034559780923 295 5393182 SGTC_952 1185-0122 232 µM 0.649395067788348 0.25214346622786 no 865 0.258041525594394 281 678600 SGTC_2947 9072639 7.68 µM 0.648591602070848 0.252413596671485 no 866 0.258301192530449 303 16488146 SGTC_600 1495-0418 41.6 µM 0.647745006401735 0.252698392632712 no 867 0.258574944804086 300 5377768 SGTC_2270 7924575 90.91 µM 0.645932979820295 0.253308529151938 no 868 0.259161380019234 299 1262135 SGTC_2197 6588183 93.1375 µM 0.643558459646463 0.254109236571414 no 869 0.259930897347549 278 884136 SGTC_353 1988-1175 58.3 µM 0.642844967764553 0.254350090936788 no 870 0.260162350685924 298 2788357 SGTC_2110 5483698 200 µM 0.642737302433743 0.254386446048039 no 871 0.260197286024095 280 2848765 YHR062C RPP1 SGTC_906 1165-0455 526 µM 0.642371264822236 0.254510065515212 no 872 0.260316076300082 293 3252859 SGTC_2064 5220758 200 µM 0.642052216313017 0.25461784133011 no 873 0.260419639977284 279 788518 SGTC_137 0438-0332 85.389 µM 0.639670696792071 0.255423082339477 no 874 0.261193355018042 306 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_679 0422-0091 41.4 µM 0.633668732869567 0.257458358219174 no 875 0.263148517199825 302 627384 YHR062C RPP1 SGTC_566 0958-0068 16.5 µM 0.633651440221038 0.257464234333225 no 876 0.263154161128433 296 6815365 SGTC_1475 4092-1048 11.7 µM 0.632888218537923 0.257723649622603 no 877 0.263403320974949 301 2881759 SGTC_2982 9019404 25.97 µM 0.632399600198081 0.25788979980031 no 878 0.263562897565165 258 22333232 SGTC_2945 9067681 61.76 µM 0.632159358517306 0.257971512153031 no 879 0.2636413755561 317 16456930 SGTC_2483 5729050 27.16 µM 0.631997314115873 0.258026635190608 no 880 0.263694316145766 299 2865180 SGTC_825 1988-2224 89.6 µM 0.631228897309088 0.258288112548821 no 881 0.263945434961717 292 1180859 SGTC_569 4130-2812 160 µM 0.631218180398705 0.258291760276624 no 882 0.263948938112518 310 743552 SGTC_1244 0416-0015 52.5 µM 0.629820978003308 0.258767556293602 no 883 0.264405859416755 285 96201 SGTC_909 3448-9333 149 µM 0.629453197192382 0.258892873825502 no 884 0.264526200150927 308 3344074 SGTC_544 k015-0020 52.4 µM 0.6288954634856 0.259082975747657 no 885 0.26470874810681 292 3008304 SGTC_3121 9125696 49.47 µM 0.628621662846499 0.259176326311051 no 886 0.264798387335698 318 1235365 SGTC_1387 3342-1166 1.8 µM 0.628507605787741 0.259215218459587 no 887 0.264835732878007 290 3418228 SGTC_1337 1486-1011 40.3 µM 0.627855514818011 0.259437631908683 no 888 0.265049297506416 293 X1337 SGTC_3239 9133757 49.47 µM 0.627115664177156 0.25969009750484 no 889 0.265291709977103 318 17036923 SGTC_3026 9090633 49.47 µM 0.625773283009563 0.260148493328413 no 890 0.265731829084379 289 25236842 SGTC_340 k038-0059 454 µM 0.625600661793902 0.260207470208001 no 891 0.265788452299457 304 23733424 SGTC_2308 7584454 197.62 µM 0.625315972007086 0.260304750912013 no 892 0.265881849608321 306 893577 SGTC_1808 st050063 61.5 µM 0.624427856765572 0.260608347126625 no 893 0.26617331769004 316 4011993 SGTC_2588 indole-3-carbinol 100 µM 0.623632155919687 0.260880506827908 no 894 0.2664345938729 297 3712 Induces cell cycle arrest. SGTC_1902 st060212 70.5 µM 0.623015508624084 0.26109152396331 no 895 0.266637165264099 287 688944 SGTC_1304 1165-0502 251 µM 0.621407329225667 0.261642256555623 no 896 0.26716582546627 288 767425 SGTC_799 1310-0557 151 µM 0.621095336397251 0.261749169749605 no 897 0.26726844877184 313 5354492 SGTC_1240 0356-0016 42.1 µM 0.620531952191742 0.261942286093479 no 898 0.267453812221214 277 4305613 SGTC_534 k292-0788 63.4 µM 0.620309182550498 0.262018667025472 no 899 0.267527125288475 319 4146317 SGTC_1152 3909-8331 15.9 µM 0.619348005442791 0.262348356266768 no 900 0.267843562990236 317 16001939 SGTC_3307 9126885 69.2785 µM 0.618639036555241 0.262591672719346 no 901 0.268077089734677 283 24824909 SGTC_414 piperonyl butoxide 100 µM 0.618153959728632 0.262758216457652 no 902 0.268236927866982 298 5794 A potent inhibitor of cytochrome P450. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.614068887879798 0.264162903829368 no 903 0.269584903193768 280 6312947 SGTC_1602 st001878 87.6 µM 0.613557715130971 0.264338943890882 no 904 0.269753816511221 314 595405 YLR310C CDC25 SGTC_643 k048-0106 28.4 µM 0.612153394661439 0.264822877569784 no 905 0.270218136647452 300 6763920 SGTC_1102 cgs 12066b 26.1 µM 0.611197062836584 0.265152690410001 no 906 0.270534563816075 296 6438352 A 5-HT1B full agonist. SGTC_1278 0874-0585 172 µM 0.609706026617445 0.265667324085673 no 907 0.271028280812238 292 766306 SGTC_1385 3091-4834 14.1 µM 0.60839467784842 0.266120356567948 no 908 0.271462870238254 300 4072814 SGTC_1189 1431-2119 7.28 µM 0.607450982189055 0.266446617582351 no 909 0.271775831706776 313 3107275 SGTC_1766 st045414 44.774 µM 0.607406863145378 0.266461875674078 no 910 0.271790467469532 323 253960 SGTC_3153 9100258 49.47 µM 0.606955187299859 0.266618108276797 no 911 0.271940326016559 321 25236848 SGTC_356 1634-0012 32.5 µM 0.606811713067058 0.266667745046598 no 912 0.271987936984894 319 735457 SGTC_2989 9073649 71.4286 µM 0.606068351866853 0.266924995269116 no 913 0.272234682810311 334 21367202 SGTC_2970 9090938 41.86 µM 0.605959314875104 0.266962739538311 no 914 0.272270885096884 309 17217104 SGTC_149 3970-0822 46.1 µM 0.605534851162028 0.267109697659563 no 915 0.272411837634109 315 3114250 YBL034C STU1 SGTC_3354 9151612 71.43 µM 0.605231295531158 0.26721481994325 no 916 0.27251266219878 288 27261949 SGTC_1853 st056710 91.2 µM 0.603635975845811 0.267767627239095 no 917 0.273042844448237 311 269167 SGTC_1451 4152-0210 104 µM 0.601720801175146 0.268432030339549 no 918 0.273680000661832 327 659563 SGTC_983 1491-0821 12.2 µM 0.601459013372692 0.268522912850443 no 919 0.273767151511203 287 46495113 SGTC_968 1309-0633 340 µM 0.60096976233476 0.268692803177498 no 920 0.273930063126793 304 3761976 SGTC_2214 7179297 48.276 µM 0.600802936141217 0.268750745202915 no 921 0.273985624141274 303 769744 SGTC_182 3448-4371 550.524 µM 0.599339241736271 0.269259384089811 no 922 0.274473342295761 272 3491403 SGTC_1092 toremifene 6.32 µM 0.59859660341571 0.269517637989241 no 923 0.274720960809197 327 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_523 1934-0222 13.7 µM 0.59851565495154 0.26954579547392 no 924 0.274747958179204 333 1361595 SGTC_1583 clindamycin 39.6 µM 0.594669515705114 0.27088535077153 no 925 0.27603220134064 324 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1145 3546-0597 10.2 µM 0.593544023329956 0.271277971061017 no 926 0.276408565013709 306 875334 SGTC_2832 7992762 51.95 µM 0.592911304276921 0.271498815239694 no 927 0.276620256172635 281 2985177 SGTC_11 0438-0307 1.3 µM 0.591863957156888 0.271864577841432 no 928 0.276970845516594 316 4011476 SGTC_1612 st002233 45.4 µM 0.588897082095696 0.272902021772435 no 929 0.277965157634036 290 1035021 SGTC_2826 7992541 19.48 µM 0.587805686493333 0.273284149569034 no 930 0.278331363365768 352 2985066 SGTC_924 2046-0044 21.3 µM 0.582921621273036 0.274997435894518 no 931 0.279973032386375 297 3623589 SGTC_1367 1812-0510 76.9 µM 0.582087188288636 0.275290675900502 no 932 0.280253977181223 287 1142582 YDR527W RBA50 SGTC_810 3825-7150 143 µM 0.580374485318008 0.275893043023919 no 933 0.280831053674934 279 22330411 YGL099W LSG1 SGTC_2170 morpholine 200 µM 0.580116335933933 0.275983891713783 no 934 0.280918084078344 313 121171 Reacts with secondary amines. SGTC_2680 butyl paraben 22.24 µM 0.579098781302903 0.276342135556085 no 935 0.281261261159127 334 7184 An antifungal and steroid mimetic. SGTC_2433 5607874 27.82 µM 0.576912975742493 0.277112448366838 no 936 0.281999122301953 319 2252428 SGTC_1984 st072354 53.1 µM 0.575909989200183 0.277466268212986 no 937 0.282338011671526 315 5762938 SGTC_1287 0971-0001 34.6 µM 0.575796441952043 0.277506337764948 no 938 0.282376389389764 304 4665869 SGTC_1369 1866-0067 208 µM 0.575631189004763 0.277564658731427 no 939 0.282432247547572 315 3531355 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.572087163918119 0.278816853312632 no 940 0.283631462396315 325 6708784 An antioxidant flavonoid SGTC_2725 haloperidol 53.21 µM 0.571485174106211 0.27902982452726 no 941 0.283835403708385 305 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2132 5317594 122.667 µM 0.571355329428252 0.279075771187976 no 942 0.283879401518627 332 794577 SGTC_94 0334-0113 514.748 µM 0.570926477567224 0.279227550259043 no 943 0.284024740968897 310 6795178 SGTC_2207 7258803 200 µM 0.570469891612919 0.279389189051273 no 944 0.284179518720004 322 3666799 SGTC_308 4092-1169 104 µM 0.569666239182432 0.279673805335289 no 945 0.284452046219436 335 2268590 YDL196W YDL196W SGTC_837 0091-0265 12.5 µM 0.566810065024482 0.280686466466102 no 946 0.285421615797598 327 759367 SGTC_519 k048-0011 62.8 µM 0.564813588687148 0.281395371955259 no 947 0.286100281668553 302 6836379 SGTC_2389 9091542 195.52 µM 0.564527054435497 0.281497184918884 no 948 0.286197746660782 314 3626624 YOL127W RPL25 SGTC_2393 9031399 185.94 µM 0.563706567655059 0.281788823165875 no 949 0.286476923484609 333 1526623 YDL150W RPC53 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.562550494829556 0.282199990909401 no 950 0.286870505157967 273 4000243 SGTC_469 w7 172 µM 0.562537589500792 0.282204582435435 no 951 0.286874900185852 319 45115570 A P450 inhibitor. SGTC_3255 9139072 49.47 µM 0.561532961044548 0.282562124758013 no 952 0.287217133486304 314 17646060 SGTC_385 1494-0393 12.4 µM 0.557400979106071 0.28403496216618 no 953 0.288626748338897 313 3090647 SGTC_15 0266-0086 27.098 µM 0.55548920531491 0.284717650964888 no 954 0.289280045808045 329 1712902 YIL048W NEO1 SGTC_2448 5185112 27.17 µM 0.554276711195779 0.285151034541701 no 955 0.289694743021712 303 5718189 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.553902066055197 0.285285008067485 no 956 0.289822935545195 325 688751 SGTC_1675 st018485 24.5 µM 0.553019538116334 0.285600719522157 no 957 0.290125015720003 315 3323024 SGTC_2005 4024620 188 µM 0.552761160902534 0.285693181644718 no 958 0.290213483479105 332 236743 SGTC_2277 7947813 106.88 µM 0.552579038816387 0.285758363883594 no 959 0.290275849251862 342 1246798 SGTC_1778 st046819 58.9 µM 0.550606693143473 0.286464727183035 no 960 0.290951659824949 335 671715 SGTC_2440 5628896 157.78 µM 0.550024288429281 0.286673464228767 no 961 0.291151357276413 333 5522048 SGTC_1847 st056231 15 µM 0.54933370708415 0.286921065794065 no 962 0.291388229706059 313 5393180 SGTC_2493 resveratrol 26.09 µM 0.548918254847698 0.287070071153718 no 963 0.291530774948992 294 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3108 9121785 49.47 µM 0.547461844995946 0.287592713704885 no 964 0.292030738361265 312 17140271 SGTC_2180 6301957 200 µM 0.546885232655182 0.287799759172999 no 965 0.292228790872524 326 845462 SGTC_3165 9101544 49.47 µM 0.546081339905991 0.288088532174706 no 966 0.292505012991394 333 5002184 SGTC_1469 k284-2957 126 µM 0.545504421731492 0.288295855990998 no 967 0.292703320116768 321 23884841 SGTC_622 1348-1566 26.3 µM 0.543429973382407 0.289041919496087 no 968 0.293416896594207 339 7340407 SGTC_2887 9044784 58.44 µM 0.543380993042255 0.289059545964843 no 969 0.293433754769224 309 6465546 SGTC_1691 st019933 84.6 µM 0.543312838790911 0.289084073356405 no 970 0.293457213015098 351 6176082 SGTC_1435 4092-0789 56.7 µM 0.543256533162942 0.289104337396824 no 971 0.293476593697853 329 2248285 SGTC_1438 4092-1045 4 µM 0.542796331594891 0.289269986075619 no 972 0.293635019632113 326 1351342 SGTC_3208 9114115 49.47 µM 0.541133649100014 0.289868836903766 no 973 0.294207733307504 341 650895 SGTC_2757 clomiphene 4.22 µM 0.539265252235041 0.290542473217412 no 974 0.294851920716316 347 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1694 st024011 44.9 µM 0.535986817051535 0.291726255322865 no 975 0.295983830751265 355 2787533 SGTC_2882 9058044 58.44 µM 0.534030405759606 0.29243374834704 no 976 0.296660248831163 305 18076804 SGTC_899 1083-0020 478 µM 0.533550852889992 0.292607289718154 no 977 0.296826159481107 351 767123 SGTC_2793 7325131 81.82 µM 0.533423242330795 0.292653477693467 no 978 0.296870315991243 331 4176441 SGTC_1101 ebselen 5.29 µM 0.532990791527507 0.292810026182694 no 979 0.29701997735546 346 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1556 plumbagin 1.48 µM 0.53220300842102 0.293095305909968 no 980 0.297292699782108 320 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1127 asiatic acid 681.4 nM 0.530149919656568 0.293839395610323 no 981 0.298003995154083 326 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1605 st000082 49.1 µM 0.529398060066886 0.294112106393469 no 982 0.298264671817111 342 1114022 SGTC_2455 5377712 9.75 µM 0.528595913307241 0.294403185989511 no 983 0.298542897926081 299 2243908 SGTC_891 0929-0073 133 µM 0.528530072801358 0.294427083816698 no 984 0.298565740070925 358 5603632 SGTC_1628 st004252 77.7 µM 0.527171836376393 0.294920276336046 no 985 0.299037132291282 318 692968 SGTC_473 2-arachidonoylglycerol 10 µM 0.526520518382242 0.295156912966937 no 986 0.299263299819495 315 5282280 An endocannabinoid. SGTC_2442 5158906 48.48 µM 0.526328243713594 0.29522678684379 no 987 0.299330081250759 313 1893835 SGTC_953 1188-0045 9.7 µM 0.526186009852548 0.29527848046194 no 988 0.299379486703434 342 6144426 SGTC_1767 st044992 70.3 µM 0.525683418905602 0.295461175982296 no 989 0.299554093122963 325 9600693 SGTC_563 tetrahydrosecaminediol 614 µM 0.523743638132114 0.296166787693938 no 990 0.300228429762892 337 334274 A psychoactive constituent of the cannabis plant. SGTC_598 3937-0236 20.2 µM 0.523527938078537 0.296245298159055 no 991 0.300303457137962 343 1379313 SGTC_107 0358-0022 2.6945 µM 0.517842710514231 0.298318038374849 no 992 0.302284008035342 358 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1653 st012112 65 µM 0.517554017548773 0.298423466992567 no 993 0.302384735589278 333 720429 SGTC_447 ml7 120 µM 0.517442018829907 0.298464372692638 no 994 0.302423816995104 350 4216 Selective myosin light chain kinase inhibitor. SGTC_750 4073-0104 132 µM 0.516627026263932 0.298762112193855 no 995 0.30270827285434 315 22330957 SGTC_3247 9135149 49.47 µM 0.51581190217399 0.299060034702282 no 996 0.30299289444277 354 8934436 YOR116C RPO31 SGTC_2244 6635614 200 µM 0.514439672406654 0.299561880103144 no 997 0.303472314128276 337 836499 SGTC_780 0109-0199 192 µM 0.513999890638936 0.299722795737157 no 998 0.303626033563315 342 610414 SGTC_3302 9125395 16.351 µM 0.513554335972795 0.299885863581013 no 999 0.303781806271565 332 17599668 SGTC_2074 5212007 75.395 µM 0.511860524416277 0.300506145174999 no 1000 0.304374313783612 333 758611 SGTC_3170 9103054 49.47 µM 0.511222379310392 0.300739987033581 no 1001 0.304597674900947 342 16432970 SGTC_1067 clotrimazole 1.36 µM 0.510739311551126 0.300917056942884 no 1002 0.304766804905949 313 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2688 kanamycin b 96.69 µM 0.510654759094275 0.30094805472888 no 1003 0.304796412410712 316 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2537 larixol 68.93 µM 0.510462006346039 0.301018725217945 no 1004 0.304863912897191 339 6708759 SGTC_930 2810-3379 265 µM 0.510444802942494 0.30102503300365 no 1005 0.304869937715799 348 1015764 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.510272066282895 0.301088371786616 no 1006 0.304930434900853 322 6708630 An antioxidant. SGTC_2372 9071633 200 µM 0.510030058340272 0.301177120945542 no 1007 0.305015201785744 317 21321366 SGTC_835 0312-0010 67.2 µM 0.507753619516008 0.302012512806407 no 1008 0.305813069998289 334 1626196 SGTC_613 3914-0030 117 µM 0.505878988801014 0.302701232235835 no 1009 0.306470801596006 322 1145395 SGTC_1229 0139-0193 12.2 µM 0.505563584039327 0.302817177712343 no 1010 0.306581525663245 345 3090752 SGTC_2782 7736369 71.43 µM 0.505493456016657 0.302842960072892 no 1011 0.306606146777831 339 2950836 YOL077C BRX1 SGTC_2108 5365811 200 µM 0.505339657476183 0.30289950709349 no 1012 0.306660146671928 307 780283 SGTC_1986 st071812 45 µM 0.504981034424731 0.303031380180037 no 1013 0.306786078386997 347 11838594 SGTC_214 4373-3496 70 µM 0.504318771339347 0.303274975459386 no 1014 0.307018694282909 339 3779166 SGTC_2706 st078239 82.5 µM 0.504249242445034 0.303300554829428 no 1015 0.307043120394286 336 15434492 SGTC_1747 st037496 66.6 µM 0.503722160941352 0.303494497119297 no 1016 0.307228316604155 331 723305 SGTC_3074 9116018 49.47 µM 0.503689983609096 0.303506338724332 no 1017 0.307239624076771 360 17027303 SGTC_2092 5303694 80.6725 µM 0.503493555003171 0.303578631042649 no 1018 0.30730865524853 343 1963699 SGTC_280 3448-3607 3.04 µM 0.502860073351283 0.303811825911007 no 1019 0.307531327070554 331 626179 SGTC_2914 7968218 45.32 µM 0.502402065579633 0.303980475757898 no 1020 0.307692363179162 340 2977111 SGTC_3115 9123671 49.47 µM 0.50143556769541 0.304336501202283 no 1021 0.308032306635185 340 3286988 SGTC_2210 7115885 190.385 µM 0.500568536728484 0.304656044254964 no 1022 0.308337405114853 354 2927039 SGTC_3270 9137563 49.47 µM 0.497442784190357 0.305809272409819 no 1023 0.309438420578662 330 17015724 SGTC_2095 5432005 200 µM 0.497325016529562 0.305852759864022 no 1024 0.309479936616286 360 783734 SGTC_2258 7960471 200 µM 0.496468016225719 0.306169302340886 no 1025 0.309782123801179 346 2974708 SGTC_3333 9141820 12.094 µM 0.495437776493344 0.30655002431932 no 1026 0.31014556720965 357 1939433 SGTC_673 1082-0474 110 µM 0.495415017511202 0.306558437191856 no 1027 0.310153598118443 339 3098046 SGTC_2813 7971799 71.43 µM 0.495138592497793 0.306660626014495 no 1028 0.310251146794256 341 2234054 SGTC_2282 7944268 200 µM 0.494945922363106 0.306731861216448 no 1029 0.310319146788958 336 2970414 SGTC_279 1273-0055 2.93 µM 0.494646419801337 0.306842609662128 no 1030 0.310424864539237 357 2847562 SGTC_2477 5967686 25.23 µM 0.494277649776388 0.306978995677504 no 1031 0.310555053679961 350 776118 SGTC_2261 9010538 184.68 µM 0.493476960182279 0.307275214910688 no 1032 0.310837807718909 357 6457250 SGTC_2100 5377183 190 µM 0.492874682923337 0.30749811338418 no 1033 0.311050568440658 335 2844202 SGTC_3210 9128157 49.47 µM 0.490850069135361 0.308247929241068 no 1034 0.311766247108438 350 17590849 SGTC_2884 9058502 51.95 µM 0.490583671743013 0.308346649217584 no 1035 0.311860468674193 329 6471554 SGTC_1966 st070145 16.1 µM 0.490098269744087 0.308526562265666 no 1036 0.312032181203432 349 3748532 SGTC_379 3970-0972 5.9 µM 0.488894787326457 0.30897282831254 no 1037 0.312458093156911 327 2898042 YBL034C STU1 SGTC_1104 tacrolimus 29.8 µM 0.488838659261176 0.308993648178093 no 1038 0.312477962978746 356 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_10 0279-0212 42.575 µM 0.488662329755183 0.309059058960316 no 1039 0.312540388699416 326 39851 YBR002C RER2 SGTC_3340 9146634 11.102 µM 0.487775342066418 0.309388185638123 no 1040 0.312854489428755 340 4907387 SGTC_4 0960-0234 25.671 µM 0.487103394406721 0.309637621172474 no 1041 0.313092530525398 319 6821112 SGTC_770 0389-1121 67.2 µM 0.4866258102249 0.309814959832414 no 1042 0.313261764687495 328 6753108 SGTC_2411 st077133 39.94 µM 0.485655155840292 0.310175523878383 no 1043 0.313605841739109 359 1403142 YNL221C POP1 SGTC_403 arphamenine a 50 µM 0.483761305412181 0.310879548265512 no 1044 0.314277639683446 365 5487158 An arginine aminopeptidase inhibitor. SGTC_2666 tannic acid 100 µM 0.483189826345857 0.311092127428782 no 1045 0.314480479177818 329 16134267 A thiamine antagonist. SGTC_2431 5490079 200 µM 0.483002491513366 0.311161826086843 no 1046 0.31454698357577 366 5722345 SGTC_1758 st042942 75.2445 µM 0.481299915162124 0.311795586490667 no 1047 0.315151678677076 342 669317 SGTC_1811 st050069 61.5 µM 0.481041330495911 0.311891889874592 no 1048 0.315243562230318 355 3877702 SGTC_3234 9132280 49.47 µM 0.480949913040189 0.311925939094462 no 1049 0.315276048564504 334 17612295 SGTC_1735 st034310 56.75 µM 0.480257088423269 0.312184039831015 no 1050 0.315522298859518 356 871153 SGTC_3343 9148379 18.9835 µM 0.479500199157762 0.31246611222233 no 1051 0.315791413282679 339 1955036 SGTC_789 1309-1135 70.6 µM 0.479133921401671 0.312602653623711 no 1052 0.315921679604252 339 3092424 SGTC_2950 9072895 21.46 µM 0.478638040701688 0.312787549532234 no 1053 0.316098075511373 310 17332245 SGTC_3310 9130229 44.1445 µM 0.47778839338511 0.313104461666651 no 1054 0.316400411469993 360 7761258 SGTC_826 1683-5028 118 µM 0.477760598366889 0.31311483133607 no 1055 0.316410304040645 352 722377 SGTC_936 3005-4620 401 µM 0.477426141505866 0.31323962093501 no 1056 0.31652935143139 373 777207 SGTC_1790 st045711 43.5 µM 0.476961357515526 0.313413072558412 no 1057 0.316694819342147 327 585119 SGTC_2979 9012552 45.46 µM 0.476693869666384 0.313512914422603 no 1058 0.316790064418372 373 17100905 SGTC_229 benomyl 22.8748 µM 0.476449175703348 0.313604260264345 no 1059 0.316877203855042 340 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1840 st055363 71 µM 0.475808690392519 0.313843411685858 no 1060 0.317105339015034 341 676033 SGTC_148 3253-0744 288.01 µM 0.475182931824664 0.314077139829398 no 1061 0.31732829579555 343 6893655 SGTC_560 2332-1943 155 µM 0.473140813240451 0.314840413549304 no 1062 0.318056360308559 342 21177716 SGTC_1425 4048-4433 7.33 µM 0.471934276613911 0.315291747720899 no 1063 0.318486850610543 378 23734946 SGTC_935 2996-0153 430 µM 0.471819734196463 0.315334609423532 no 1064 0.318527731909682 354 23738523 SGTC_522 1273-0010 11.6 µM 0.470528228266149 0.315818062041956 no 1065 0.318988835698808 350 5705015 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.470193467745466 0.315943425259412 no 1066 0.319108400346749 341 2374 Ca(2+)-ATPase inhibitor. SGTC_2965 9082772 38.63 µM 0.469043843781335 0.316374104764155 no 1067 0.319519148706302 292 16459634 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.46845505398661 0.316594777501277 no 1068 0.319729602825339 330 4174840 SGTC_1190 1486-1332 13 µM 0.467932713770755 0.316790600240419 no 1069 0.319916354134003 356 4150046 SGTC_1171 0368-0077 21.4 µM 0.464946376533073 0.317911147732691 no 1070 0.320984929025638 365 3239779 SGTC_2858 9025781 8.96 µM 0.464713399333082 0.317998636857953 no 1071 0.321068355746104 338 4894980 YPL153C RAD53 SGTC_507 nimesulide 162 µM 0.463345580946552 0.318512493749086 no 1072 0.321558339410583 356 4495 A COX2 inhibitor. SGTC_2659 sanguinarine 24.21 µM 0.463216940358351 0.318560838948302 no 1073 0.321604437388261 361 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1946 st076057 65.1 µM 0.462909319895048 0.318676460183962 no 1074 0.321714683417044 358 953009 SGTC_2339 9000433 200 µM 0.462839198287625 0.318702818336574 no 1075 0.321739816025897 334 2988954 SGTC_372 0155-0182 15.9 µM 0.462836628138486 0.318703784452551 no 1076 0.321740737220406 339 771486 SGTC_2321 7390090 138.78 µM 0.461302291011592 0.319280759695835 no 1077 0.322290870747065 356 649046 SGTC_2764 methyldopa 94.69 µM 0.460669201409061 0.319518955707525 no 1078 0.322517977342085 367 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1715 st032160 10.2275 µM 0.460002931425187 0.319769716074383 no 1079 0.322757058191018 358 5289825 SGTC_464 bw-b 70c 158 µM 0.459963555698246 0.319784538279833 no 1080 0.322771189866043 372 5353454 SGTC_3327 9140648 26.9345 µM 0.459055366999015 0.32012648759141 no 1081 0.323097203480521 387 8029710 SGTC_1413 3910-0535 34.4 µM 0.458180523870701 0.320456026238373 no 1082 0.323411375547564 356 2876951 SGTC_2505 galangin 7.89 µM 0.457380295698097 0.320757582708901 no 1083 0.323698862333343 377 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2727 riluzole 51.77 µM 0.456679488182143 0.32102177087715 no 1084 0.323950718096174 365 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2080 5212524 12.4 µM 0.453116857666955 0.322366199029074 no 1085 0.325232298560833 362 260183 SGTC_3051 9093778 49.47 µM 0.453080062084353 0.322380096729001 no 1086 0.325245545813162 386 17217378 SGTC_210 3551-0445 56.827 µM 0.452294041265132 0.322677036238587 no 1087 0.325528584033463 353 2865180 YOR207C RET1 SGTC_2818 7996756 12.99 µM 0.452240596195213 0.322697230592729 no 1088 0.325547832723316 372 2241621 SGTC_3325 9138760 55.175 µM 0.451728912744941 0.322890597935221 no 1089 0.325732143349799 324 43844959 SGTC_1765 st044815 90.4 µM 0.451090617907089 0.32313187938349 no 1090 0.325962119675077 356 645695 SGTC_412 gemfibrozil 100 µM 0.448253270501531 0.324205323042347 no 1091 0.326985210610618 358 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1782 st039423 80.636 µM 0.446727328423421 0.32478323291557 no 1092 0.327535973759331 353 2068169 SGTC_2652 actinonin 100 µM 0.446399933817468 0.324907279922731 no 1093 0.327654190309592 348 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2118 5526350 200 µM 0.443736070273976 0.325917315632268 no 1094 0.328616706872667 361 743594 SGTC_2303 7774051 200 µM 0.441229977642064 0.326868698443907 no 1095 0.329523256470205 380 2953184 SGTC_1857 st056007 79.3 µM 0.440855989942145 0.32701077138063 no 1096 0.329658628249531 337 619834 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.440070778877088 0.327309144160058 no 1097 0.329942922559397 362 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_208 k072-0098 12.366 µM 0.439932061908179 0.327361866773256 no 1098 0.329993156781194 352 5948901 SGTC_2131 toluylene red 5.2905 µM 0.439685260724085 0.327455677822343 no 1099 0.330082539621893 319 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2287 7945887 168.79 µM 0.437864518930909 0.328148092317851 no 1100 0.330742248688054 369 1245853 SGTC_448 monastrol 171 µM 0.43764673898804 0.328230952015457 no 1101 0.330821192123298 377 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_897 1000-0139 31.4 µM 0.437044263252957 0.328460222643657 no 1102 0.33103962380623 374 6151020 SGTC_1821 st053465 65.6 µM 0.435150270886332 0.3291813971544 no 1103 0.331726678001541 333 675086 SGTC_3110 9122132 49.47 µM 0.435137321190418 0.329186330196012 no 1104 0.33173137751372 347 918317 SGTC_1044 1222-0021 1.78 µM 0.433814636298674 0.329690348716897 no 1105 0.332211526132429 346 4306703 SGTC_1353 1498-1206 8.11 µM 0.431148171769273 0.330707364099328 no 1106 0.333180318071024 358 6756808 SGTC_2017 5132927 60.65 µM 0.430901179386871 0.330801632806252 no 1107 0.333270112939066 352 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2544 sphondin 68.51 µM 0.430135995720129 0.331093745841124 no 1108 0.333548358548845 347 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_603 3794-0023 45.9 µM 0.429465488128028 0.331349800315958 no 1109 0.333792252166828 360 3802260 SGTC_827 3253-0474 693 µM 0.429374889733097 0.331384404221144 no 1110 0.33382521224623 350 5402065 SGTC_2242 6630449 61.2675 µM 0.429035679296748 0.33151397786225 no 1111 0.33394862982387 365 691249 YDR170C SEC7 SGTC_1303 1160-0052 261 µM 0.428773596913448 0.331614103476988 no 1112 0.33404399760187 367 3562476 SGTC_2968 9090663 33.37 µM 0.427450676503679 0.332119693812584 no 1113 0.334525551618896 398 25236811 SGTC_1342 1486-1464 234 µM 0.427279996653818 0.332184946088546 no 1114 0.334587700354844 364 3253938 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.426642381363134 0.332428756525698 no 1115 0.334819911863898 371 364106 SGTC_474 dl-dihydrosphingosine 5 µM 0.426251701920876 0.33257817902696 no 1116 0.334962223646796 331 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1724 st037281 8.293 µM 0.423767380376687 0.333528974903761 no 1117 0.335867734788622 342 574124 YDL195W SEC31 SGTC_2580 diallyl disulphide 81.36 µM 0.421013976887521 0.33458400393833 no 1118 0.336872437856932 339 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2939 9044578 71.43 µM 0.418962606500209 0.335370883564988 no 1119 0.337621730463512 375 2653634 SGTC_373 0844-0104 25.9 µM 0.418107722950553 0.335699019610551 no 1120 0.337934179339843 374 5375804 SGTC_533 1222-0222 6.71 µM 0.417531732970427 0.335920176630196 no 1121 0.338144759219675 395 3982874 SGTC_1926 methyl fluorone black 53.6 µM 0.41696434691478 0.336138085648376 no 1122 0.33835224305581 340 72721 Reacts with homocysteine. SGTC_1560 lithocholic acid 53.1 µM 0.414647573509488 0.337028431372668 no 1123 0.339199958235699 377 9903 A bile acid which acts as a detergent. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.414577430045767 0.337055402075961 no 1124 0.339225636691118 365 6708514 SGTC_1332 1480-0653 17.5 µM 0.413747042520825 0.337374756112666 no 1125 0.339529685654854 378 5749438 SGTC_1690 st023502 41.2 µM 0.413467002524476 0.337482481545079 no 1126 0.339632246734144 402 24207482 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.413000047987128 0.337662138648365 no 1127 0.339803289289721 382 5024745 SGTC_3289 9119912 71.43 µM 0.410845386335855 0.33849160657889 no 1128 0.340592955334187 375 17014829 SGTC_2892 9047358 58.44 µM 0.410062317681021 0.338793254599669 no 1129 0.340880117081692 382 6466771 SGTC_396 dithiazanine 1.25 µM 0.409900819387354 0.338855478669516 no 1130 0.340939352141892 350 10578 An antihelmenthic. SGTC_979 1426-2828 121 µM 0.409135641084729 0.33915035582765 no 1131 0.341220060915215 377 747872 SGTC_2848 9016370 25.97 µM 0.408433370010746 0.339421077136516 no 1132 0.34147776927019 366 7894410 SGTC_1301 naphtanilide LB 4.81 µM 0.408050171710458 0.339568832760323 no 1133 0.341618420517134 366 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2409 alverine citrate 63.97 µM 0.406590138968214 0.340132025713776 no 1134 0.342154520500005 320 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2173 5763948 167 µM 0.404263436158649 0.341030265069021 no 1135 0.343009504948122 368 2867177 SGTC_1299 1079-1439 3.74 µM 0.400411090918498 0.342519469747633 no 1136 0.344426878330242 378 323161 SGTC_384 k007-0144 5.16 µM 0.398855908356794 0.343121354023169 no 1137 0.344999689511521 374 6824886 SGTC_278 4092-0821 23.9 µM 0.396094297851481 0.344191128792735 no 1138 0.346017732348105 370 877900 SGTC_2224 6650123 117.647 µM 0.394068544681147 0.344976646011637 no 1139 0.346765216799426 398 2908370 SGTC_329 k048-0121 21.3 µM 0.391947476561092 0.345799839632382 no 1140 0.347548511290273 365 6832902 SGTC_971 1315-0384 26.7 µM 0.390179902453635 0.346486398547475 no 1141 0.348201760880182 392 6769120 SGTC_85 0868-0259 160.055 µM 0.389906647729001 0.346592580895923 no 1142 0.348302789011237 389 83173 SGTC_2690 usnic acid 100 µM 0.388169786308666 0.347267778535531 no 1143 0.348945195314728 399 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1707 st032323 6.317 µM 0.387580643321734 0.34749691568963 no 1144 0.349163197869042 361 3132057 YMR211W DML1 SGTC_3113 9123498 49.47 µM 0.387397330973497 0.347568223285752 no 1145 0.349231039709932 400 8897275 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.386306332258892 0.347992727892066 no 1146 0.349634905678708 351 6857784 SGTC_2761 levamisole 97.89 µM 0.385808712477887 0.348186413702299 no 1147 0.349819171159144 389 26879 An alkaline phosphatase inhibitor. SGTC_2265 7929201 200 µM 0.385626999848777 0.348257150583536 no 1148 0.349886467025366 425 1265108 SGTC_2345 9052315 157.45 µM 0.384869039272383 0.348552265505062 no 1149 0.350167222699032 370 6469265 SGTC_1838 st055369 84.5 µM 0.382869611713207 0.34933118998535 no 1150 0.3509082220085 336 676036 SGTC_55 0767-0285 6.563 µM 0.382625728500396 0.349426243997637 no 1151 0.350998645405464 390 3116166 SGTC_981 1488-1094 54.9 µM 0.381727506862929 0.349776409231483 no 1152 0.351331747423893 364 3449522 SGTC_323 4013-0906 34.3 µM 0.381031800503738 0.350047713205693 no 1153 0.351589825949915 383 2910086 SGTC_813 k007-0158 173 µM 0.38092980408932 0.350087495092574 no 1154 0.351627668189968 392 6523916 SGTC_295 k015-0027 31 µM 0.379994189224932 0.350452491741409 no 1155 0.351974864269927 381 3887424 SGTC_2272 7805186 180 µM 0.379906342533978 0.350486769081968 no 1156 0.352007469526214 426 2956062 YPR165W RHO1 SGTC_1363 1636-0063 10.4 µM 0.378529132246726 0.351024308672424 no 1157 0.352518778244972 382 6072185 SGTC_623 k072-0108 16.9 µM 0.377034088522944 0.351608177510257 no 1158 0.353074136075931 401 5382803 SGTC_966 1300-0360 30.2 µM 0.376841319299154 0.351683486408438 no 1159 0.353145766090995 389 70588 SGTC_79 0052-0007 94.094 µM 0.376637942009914 0.351762945855461 no 1160 0.353221343537528 400 2801472 SGTC_1399 3562-5772 25 µM 0.375675018653788 0.352139247589343 no 1161 0.353579255988006 368 23847490 SGTC_1784 st039334 36.3 µM 0.375014554906082 0.352397434606636 no 1162 0.353824821026079 381 3496984 SGTC_81 0411-0046 9.971 µM 0.374708803516074 0.352516981302712 no 1163 0.353938522134001 364 12925265 SGTC_133 0724-0033 378.92 µM 0.373437986879621 0.353014017892936 no 1164 0.354411245775385 394 280309 SGTC_3221 9128209 49.47 µM 0.372319507031356 0.353451680779639 no 1165 0.354827488226625 388 16460723 SGTC_2490 carminic acid 95.39 µM 0.371802317791553 0.353654123300857 no 1166 0.355020018929774 379 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_54 0159-0055 9 µM 0.371239591036074 0.353874437519675 no 1167 0.355229543648037 400 3319099 SGTC_392 N-ethylmaleimide 8.33 µM 0.370234381576 0.354268110736095 no 1168 0.355603930524098 361 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1093 fluphenazine 7.97 µM 0.370050224783028 0.354340249513376 no 1169 0.35567253421481 401 6602611 An atypical antipsychotic. SGTC_2731 amoxapine 43.43 µM 0.369629337250535 0.354505141204057 no 1170 0.355829344450259 404 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_499 genistein 192 µM 0.369010318140698 0.354747704720957 no 1171 0.356060016967355 407 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_460 trequinsin 123 µM 0.368990430640788 0.354755498643126 no 1172 0.35606742875915 385 5537 A vasodilator. SGTC_2674 ligustilide 100 µM 0.368911520335658 0.354786424234343 no 1173 0.356096838057206 386 5319022 A signalling regulator. SGTC_1822 st052468 42 µM 0.368879590328753 0.354798938136052 no 1174 0.356108738382369 365 2873678 SGTC_1934 st074720 32.6 µM 0.368162848873422 0.355079882262649 no 1175 0.356375905049985 376 17250992 SGTC_2649 anisomycin 9.56 µM 0.366406008200569 0.355768851446913 no 1176 0.357031068556358 382 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2120 5538279 151.968 µM 0.366236485096229 0.35583535723239 no 1177 0.357094309697968 371 2058197 SGTC_927 2425-1185 123 µM 0.365780779332302 0.356014157381101 no 1178 0.357264331665006 407 730375 SGTC_1228 0124-0032 52.5 µM 0.364404172358772 0.3565544733882 no 1179 0.357778110132839 389 X1228 SGTC_249 wiskostatin 11.211 µM 0.364239860741709 0.356618984692805 no 1180 0.35783945189763 393 2775510 A n-wasp and actin depolymerizer. SGTC_2450 5739737 12.93 µM 0.364157062708111 0.356651494047082 no 1181 0.357870363930429 380 2262825 SGTC_1561 5-methoxyflavone 52.9 µM 0.363490748127371 0.356913149949053 no 1182 0.35811916146117 399 94525 SGTC_3063 1327-0034 4 µM 0.363375306327832 0.356958489779145 no 1183 0.358162272806127 409 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2673 kobusone 100 µM 0.362048937461413 0.357479566698168 no 1184 0.358657730353282 408 6710676 An epoxy ketone and protein crosslinker. SGTC_841 0251-0215 91.2 µM 0.3603950574784 0.358129681846059 no 1185 0.359275861108596 402 3888614 SGTC_38 0929-0051 58.268 µM 0.360393248815206 0.358130393029768 no 1186 0.359276537290939 410 1379719 SGTC_3276 9139060 49.47 µM 0.359802625373096 0.358362658143777 no 1187 0.359497369869764 421 4870619 SGTC_1059 3448-6867 171 µM 0.359761807745652 0.358378711782027 no 1188 0.359512633209818 383 3934407 SGTC_1521 st012942 49.4 µM 0.358353500286305 0.358932754493219 no 1189 0.360039392702764 373 24207259 SGTC_721 1187-1332 279 µM 0.358293945105921 0.358956190667876 no 1190 0.360061674427095 389 25730 SGTC_2636 apigenin dimethyl ether 100 µM 0.357012643361989 0.359460537412422 no 1191 0.360541170303872 396 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_895 0964-0006 13.7 µM 0.356860421341157 0.359520471427886 no 1192 0.360598150270327 408 6738897 SGTC_1791 st048313 56.1 µM 0.355935611333895 0.359884668907453 no 1193 0.360944392972846 390 1204976 SGTC_1447 4239-0816 81.9 µM 0.355207996993681 0.360171298639088 no 1194 0.361216887069154 371 1341554 SGTC_406 estrone 100 µM 0.354215591318346 0.360562364568849 no 1195 0.361588659965096 408 5870 A steroid. SGTC_1944 st076371 56.9 µM 0.35159831035245 0.361594425259734 no 1196 0.362569766270026 384 24208455 SGTC_2973 9094665 17.96 µM 0.3515181695816 0.361626042749561 no 1197 0.362599821887842 426 25237061 YIL048W NEO1 SGTC_2179 6298986 200 µM 0.350353694224941 0.362085563196045 no 1198 0.363036636698063 400 738374 SGTC_732 3970-1727 52.7 µM 0.349298890514569 0.362501977144553 no 1199 0.363432465650944 420 1275699 SGTC_322 k048-0136 19.3 µM 0.34837853767789 0.362865445712405 no 1200 0.363777959322482 387 6823282 SGTC_2862 9027634 71.43 µM 0.347974693669513 0.363024972057396 no 1201 0.363929594375739 356 5012562 SGTC_923 1900-2434 73.3 µM 0.346683298035668 0.363535258203172 no 1202 0.364414629587199 420 5910570 SGTC_1863 st057641 20.1 µM 0.34654980610376 0.363588020454519 no 1203 0.36446478021285 407 3921635 SGTC_3024 9090631 49.47 µM 0.345056878511081 0.364178271291308 no 1204 0.365025805347462 392 25236383 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.345037290889411 0.364186017690185 no 1205 0.365033168075642 425 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1727 st034309 9.9045 µM 0.344662589944583 0.364334212923426 no 1206 0.365174022787713 418 870305 SGTC_2460 5552655 174.22 µM 0.344426468848713 0.364427609872682 no 1207 0.365262792968344 370 5401989 SGTC_169 k015-0017 16.025 µM 0.344368800277296 0.364450421716145 no 1208 0.365284474675936 411 1840002 SGTC_2594 a-mangostin 100 µM 0.344093842362754 0.364559192878112 no 1209 0.365387856783968 424 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_268 camptothecin 39.6153 µM 0.343697344516749 0.364716063469348 no 1210 0.365536954213237 404 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_6 0844-0013 19.835 µM 0.343356750597444 0.364850834293931 no 1211 0.36566504598341 407 1584900 SGTC_1345 1488-0192 31.4 µM 0.343265130236455 0.364887090733003 no 1212 0.365699505451455 410 658348 SGTC_1117 retinoic acid 1.10837 µM 0.340912112711991 0.365818650994745 no 1213 0.366584872928422 399 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2052 5265182 7.135 µM 0.340703164399299 0.365901412042072 no 1214 0.366663528105817 424 1239884 SGTC_2491 paeonol 100 µM 0.34035666246479 0.366038669608069 no 1215 0.366793975437024 402 11092 Increases levels of cortical cytochrome oxidase. SGTC_3104 9120930 49.47 µM 0.33824680695294 0.366874802458637 no 1216 0.367588602749509 413 17014836 SGTC_1043 0916-0009 19.3 µM 0.336986122764517 0.367374711773626 no 1217 0.368063680667618 415 3101130 SGTC_970 1315-0089 19.5 µM 0.336060971537164 0.367741712597984 no 1218 0.368412444362017 386 6811083 YLR033W RSC58 SGTC_1881 5652484 16 µM 0.336059772826142 0.367742188196434 no 1219 0.368412896322744 418 2255129 SGTC_1970 st070122 35.8 µM 0.334908705881162 0.368198976965121 no 1220 0.368846977321539 416 102928 SGTC_1115 galangin 695.678 nM 0.334869570037638 0.368214510891511 no 1221 0.368861738857271 434 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1818 st052136 56.3 µM 0.333716085419852 0.368672452419272 no 1222 0.369296905181469 403 674169 SGTC_52 0329-0193 875 nM 0.332977448273747 0.368965794598771 no 1223 0.369575653197911 423 3739292 SGTC_2767 sibutramine 71.45 µM 0.332506071703624 0.36915303689372 no 1224 0.369753577858515 427 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_477 mead ethanolamide 10 µM 0.332133186192463 0.369301178132 no 1225 0.369894346081002 381 16061185 SGTC_1271 0832-2808 169 µM 0.331932729857104 0.369380824137827 no 1226 0.369970027673494 419 3663794 SGTC_2676 harmalol 100 µM 0.331669640704734 0.369485364138767 no 1227 0.370069363709749 391 5459187 A monoamine oxidase inhibitor SGTC_3344 9148862 3.898 µM 0.331472570373906 0.369563677499953 no 1228 0.370143778330697 404 4905352 SGTC_1370 2001-0092 44.6 µM 0.331090663683712 0.369715457993115 no 1229 0.370288001807489 422 790957 SGTC_1672 st016598 6.51 µM 0.330386324038525 0.369995435670631 no 1230 0.370554036883047 418 4665860 YNL267W PIK1 SGTC_3004 9076122 71.4286 µM 0.329947240139457 0.370170008065161 no 1231 0.370719913943867 429 44782551 SGTC_2236 dapsone 200 µM 0.329778217735396 0.370237215670574 no 1232 0.370783773614543 390 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_455 paf C-16 10 µM 0.329630146541561 0.370296095797817 no 1233 0.370839720470515 405 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_257 daunorubicin 18.5 µM 0.329299953947682 0.370427406972286 no 1234 0.370964489461466 416 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2566 crystal violet carbinol 226 nM 0.326607258882936 0.371498801823586 no 1235 0.37198247629875 438 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_655 k060-0012 42 µM 0.326504635904398 0.371539654180889 no 1236 0.372021291189027 425 5994525 SGTC_2141 5621638 7.665 µM 0.326119819399848 0.371692855574639 no 1237 0.372166851169041 406 2856238 SGTC_3080 9117754 49.47 µM 0.324644003372868 0.372280588958602 no 1238 0.372725259821236 409 9550191 SGTC_3189 9110682 49.47 µM 0.324402968237643 0.372376607820615 no 1239 0.37281648641295 403 17122418 SGTC_1329 1447-1697 50.6 µM 0.321980867976081 0.373341916256035 no 1240 0.373733594246668 388 2840515 SGTC_1664 st014217 9.02 µM 0.321210332865714 0.373649173846198 no 1241 0.374025501113306 424 3982782 SGTC_2225 6654152 15.4 µM 0.320543946880598 0.373914965849471 no 1242 0.374278010756952 419 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_289 k017-0060 526 µM 0.320060625432066 0.374107779001315 no 1243 0.374461186610175 430 5512909 SGTC_1121 fusaric acid 630.51 nM 0.318863056275113 0.374585665167039 no 1244 0.374915179963637 375 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_753 1322-0200 289 µM 0.318602280038005 0.374689752669513 no 1245 0.375014062131524 390 5403907 SGTC_2799 7812892 81.82 µM 0.317683055843388 0.375056729079887 no 1246 0.37536268268944 410 20205235 SGTC_108 0509-0257 621.132 µM 0.317547209286004 0.375110971896581 no 1247 0.375414211844963 390 536624 SGTC_588 3970-1144 52.9 µM 0.317095821119355 0.375291226553886 no 1248 0.375585447830312 401 1888707 SGTC_1391 3442-0225 151 µM 0.315883760436485 0.37577537828227 no 1249 0.376045369297605 398 5227075 SGTC_908 3448-7491 47.7 µM 0.313246469644359 0.376829506293319 no 1250 0.377046707967828 376 1203031 SGTC_3356 9151811 4.48 µM 0.312965211288767 0.376941979924878 no 1251 0.377153546376326 420 1859254 YPR165W RHO1 SGTC_2486 5283202 22.39 µM 0.31292579875313 0.376957741610253 no 1252 0.377168518318852 397 1377751 SGTC_288 1315-0019 35.1 µM 0.312866475703776 0.376981466206005 no 1253 0.377191054169232 410 6811474 SGTC_2091 4-phenylthiadiazole 200 µM 0.309966454554237 0.378141813326566 no 1254 0.378293233106859 389 270010 SGTC_567 1080-0542 68.4 µM 0.309499730892086 0.378328660329502 no 1255 0.378470708419741 400 5950415 SGTC_1220 1838-0075 193 µM 0.30815677788722 0.378866453425838 no 1256 0.378981519674096 404 5529645 SGTC_740 k014-0057 261 µM 0.308113928456243 0.378883616589489 no 1257 0.378997821549136 439 4012779 SGTC_647 0140-0236 81 µM 0.307777906859512 0.379018216937734 no 1258 0.379125666927516 410 990837 SGTC_868 0527-0199 213 µM 0.30751941743763 0.379121770166755 no 1259 0.379224022813127 384 2849450 SGTC_1180 1193-0155 285 µM 0.307250954088614 0.37922932822591 no 1260 0.379326182080442 411 2921347 SGTC_3112 9123419 49.47 µM 0.306434726520905 0.379556401778714 no 1261 0.379636835652595 437 17015854 SGTC_1687 st020778 55.3625 µM 0.305795621955155 0.379812559909881 no 1262 0.379880131037796 412 4259299 SGTC_2078 5212016 200 µM 0.304137529801188 0.380477381958341 no 1263 0.380511557807277 441 1899708 SGTC_1895 st058434 18.3 µM 0.303856905015014 0.380589935156966 no 1264 0.380618455561141 423 5393175 SGTC_2312 7706453 155.7 µM 0.302016515216637 0.381328330185709 no 1265 0.381319736579325 400 976098 SGTC_714 4296-0578 26.1 µM 0.30089236698063 0.38177956998032 no 1266 0.381748285514756 411 1589775 SGTC_128 0906-2981 13.371 µM 0.300134308374412 0.382083949971375 no 1267 0.382037355265636 414 6740226 SGTC_3238 9133470 49.47 µM 0.29881460530286 0.382614018448281 no 1268 0.382540753195341 421 3534688 SGTC_3329 9141233 27.5565 µM 0.297987675295834 0.382946273162119 no 1269 0.382856285124055 426 4909101 YNL103W MET4 SGTC_2600 tangeritin 87.95 µM 0.29658553969292 0.383509838231545 no 1270 0.383391476027753 406 68077 A bioactive flavone. SGTC_1643 st009866 20.2 µM 0.294298262738525 0.384429699793748 no 1271 0.384265000019535 409 3156273 YOR207C RET1 SGTC_1468 k284-1086 134 µM 0.291290926546846 0.385640133878063 no 1272 0.385414413144176 413 15996457 SGTC_1454 4239-0054 42.6 µM 0.29008891120778 0.386124250004221 no 1273 0.385874109407152 448 1340767 SGTC_3027 9089541 49.47 µM 0.290060361967134 0.386135750475806 no 1274 0.385885029671282 406 9943819 SGTC_2128 5255449 168.493 µM 0.289580782393224 0.386328954145099 no 1275 0.38606848538723 373 736008 SGTC_316 k060-0003 58.6 µM 0.288786374702923 0.386649051623836 no 1276 0.386372429749247 421 6152314 SGTC_2874 9043904 71.43 µM 0.287434414406757 0.387193985772208 no 1277 0.386889856766983 412 4463428 SGTC_2223 6903751 107.57 µM 0.286831585581755 0.387437039521183 no 1278 0.387120638424316 422 5598863 SGTC_736 0958-0254 92.6 µM 0.286630620606064 0.387518076133287 no 1279 0.387197582952197 447 6812352 SGTC_1519 esterone 74 µM 0.286556796175511 0.387547846142267 no 1280 0.387225849617443 399 698 A steroid. SGTC_2076 5212012 200 µM 0.285569350143669 0.387946101366611 no 1281 0.387603990651711 417 604802 SGTC_1810 st050138 53 µM 0.285392620893415 0.38801739198742 no 1282 0.387671680124571 450 3444541 SGTC_2429 5902844 64.44 µM 0.284004874702331 0.388577324415075 no 1283 0.38820332246427 430 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1562 morin hydrate 59.1 µM 0.283845603150725 0.388641602665432 no 1284 0.388264352449978 411 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1109 tnp00067 928.257 nM 0.283278095996544 0.388870659975778 no 1285 0.388481833375722 418 676295 SGTC_130 0136-0219 337.655 µM 0.282484954630501 0.389190852512739 no 1286 0.388785840743474 450 234244 SGTC_1010 4112-3296 15.2 µM 0.282041261800439 0.389370004914355 no 1287 0.388955935849349 402 704384 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.281634978458095 0.3895340728995 no 1288 0.389111708239017 445 368090 SGTC_1164 k060-0068 93.7 µM 0.279630004148579 0.390344022506126 no 1289 0.389880692529927 404 5963676 SGTC_3106 9121286 49.47 µM 0.278277055396966 0.390890842601892 no 1290 0.390399843958465 380 15943471 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.278181643493454 0.390929413304779 no 1291 0.390436462658009 430 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3309 9129340 25.759 µM 0.277272489987592 0.39129699658211 no 1292 0.390785440777883 387 17158987 SGTC_564 3555-0129 330 µM 0.275110310517267 0.392171585033959 no 1293 0.391615745233959 432 563260 SGTC_1720 st037298 9.481 µM 0.273147672327001 0.392965932294614 no 1294 0.392369851148977 430 597396 SGTC_2853 9015042 58.44 µM 0.272168386313515 0.393362450037036 no 1295 0.392746274324673 411 6457456 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.271424316271564 0.393663801660354 no 1296 0.39303235103419 422 688788 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.270845753046633 0.39389816633026 no 1297 0.393254834365242 453 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2099 5377090 177.372 µM 0.270372052487929 0.394090081800345 no 1298 0.393437019293106 420 2243829 SGTC_2240 6690706 185.951 µM 0.269807208192939 0.394318956941026 no 1299 0.393654288541265 388 805876 SGTC_1661 st013063 9.66 µM 0.268723818842493 0.394758048814455 no 1300 0.394071110493046 426 721395 SGTC_2040 5100729 123 µM 0.266829949529294 0.395525944744649 no 1301 0.394800046808307 422 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_348 k064-0012 10.7 µM 0.266686179865617 0.395584254783573 no 1302 0.394855397767831 413 5066323 SGTC_2362 9071156 126 µM 0.266678952154815 0.395587186257157 no 1303 0.394858180474379 406 653133 SGTC_555 4296-0685 37 µM 0.265316090455575 0.396140052157932 no 1304 0.395382985079634 437 2908540 YHR072W ERG7 SGTC_1256 0570-0116 285 µM 0.265131538425978 0.396214934628024 no 1305 0.395454066149628 409 410638 SGTC_699 0375-0592 111 µM 0.262209551401269 0.397401047076611 no 1306 0.396579944999334 428 762578 SGTC_104 0074-0074 590.992 µM 0.262152097271733 0.397424378792303 no 1307 0.396602091487954 414 3943124 SGTC_977 1348-1378 135 µM 0.260387340243118 0.398141212524549 no 1308 0.397282503634186 451 X977 SGTC_2787 5284540 71.43 µM 0.260228137939164 0.398205896494995 no 1309 0.397343900399506 434 736958 SGTC_3263 9137018 49.47 µM 0.259764502197241 0.398394287843619 no 1310 0.397522717164123 461 43844957 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.258558396864901 0.398884481283003 no 1311 0.397987993172321 432 229346 A bile salt which induces apoptosis. SGTC_1038 k292-0204 154 µM 0.258466952699081 0.398921653151478 no 1312 0.398023275268376 404 4454212 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.25832620667277 0.398978867917816 no 1313 0.398077581235039 430 5106787 A p450 inhibitor. SGTC_585 0kpi-0023 191 µM 0.258158861688656 0.399046898269802 no 1314 0.398142152811252 437 64601 SGTC_2383 9036125 200 µM 0.257667649446859 0.399246607299666 no 1315 0.398331707605126 445 79580 SGTC_2932 9016711 44.54 µM 0.257052038721098 0.39949692945782 no 1316 0.398569300630472 419 7117328 SGTC_2465 5809242 33.21 µM 0.256941317677636 0.399541955689842 no 1317 0.398612037061245 438 2731748 SGTC_271 rotenone 740 µM 0.256437829367494 0.399746722965634 no 1318 0.39880639027305 441 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.255160219139739 0.400266447082513 no 1319 0.399299677411359 403 5282362 SGTC_215 1287-0124 461.5 µM 0.254768874479703 0.400425679112254 no 1320 0.399450808357792 445 5560863 SGTC_2726 cimetidine 79.27 µM 0.254051992744698 0.400717410005225 no 1321 0.399727695500243 452 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_784 4579-0127 173 µM 0.253811098176153 0.400815453102647 no 1322 0.399820749522826 467 1948547 SGTC_1372 2752-0194 270 µM 0.253315788879964 0.401017061570567 no 1323 0.400012098076921 431 823334 SGTC_1203 3992-3522 103 µM 0.252977171404946 0.401154906079768 no 1324 0.400142927056397 453 5322312 SGTC_1094 duloxetine 25.4 µM 0.252385184968568 0.401395921656663 no 1325 0.400371675131054 425 60834 A selective serotonin reuptake inhibitor. SGTC_1036 k216-0215 33.5 µM 0.250972193440229 0.401971344723904 no 1326 0.400917803848789 425 622330 SGTC_1003 4049-0218 100 µM 0.250725672357684 0.4020717591527 no 1327 0.401013105428646 441 295161 SGTC_482 fipronil 114 µM 0.250510498416326 0.402159410361592 no 1328 0.401096293459973 420 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_709 3807-1509 243 µM 0.24967418276763 0.402500130632377 no 1329 0.401419662581584 448 1886677 YPL242C IQG1 SGTC_1325 1431-0015 227 µM 0.248166613346941 0.403114510887747 no 1330 0.402002748572892 412 1103340 SGTC_2797 7859098 81.82 µM 0.247927821388732 0.403211847840464 no 1331 0.402095126721028 419 972681 SGTC_2114 5491910 81.25 µM 0.246229990310085 0.403904094402042 no 1332 0.40275210058744 469 2849228 SGTC_305 1682-2595 20.8 µM 0.245856254660224 0.404056515921866 no 1333 0.402896754138611 437 226033 SGTC_717 1532-0246 73.2 µM 0.245599035706711 0.404161426618278 no 1334 0.402996317885153 401 9561992 SGTC_1835 st008666 49.2 µM 0.245227805990184 0.404312850504737 no 1335 0.403140023755095 423 690455 SGTC_463 ikarugamyin 104 µM 0.245051781036533 0.404384655756154 no 1336 0.403208168938106 457 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_592 k241-0073 46.5 µM 0.244989725677648 0.404409970552408 no 1337 0.403232193356682 445 4230158 SGTC_2749 bexarotene 57.39 µM 0.243821483184141 0.404886616709164 no 1338 0.403684540598829 425 82146 An retinoic acid receptor inhibitor. SGTC_1144 3486-0183 12.5 µM 0.243787555383507 0.40490046145786 no 1339 0.403697679480504 463 6744069 SGTC_2281 7943571 200 µM 0.242502092547139 0.405425101422959 no 1340 0.4041955678109 460 1244024 SGTC_2485 5633444 17.78 µM 0.242453550948297 0.405444916193607 no 1341 0.404214372097568 414 5724239 SGTC_2264 7948757 110.76 µM 0.241852773014516 0.405690174904405 no 1342 0.404447122756546 434 2971411 SGTC_2032 5185112 25.99 µM 0.241065916358244 0.406011453494999 no 1343 0.404752014333294 451 5718189 SGTC_362 0310-0100 9.03 µM 0.240990755880913 0.406042145312917 no 1344 0.404781140578434 403 790235 SGTC_1033 k072-0102 21.3 µM 0.238069868874988 0.4072353364554 no 1345 0.405913452041219 453 5965931 SGTC_103 0844-0104 51.839 µM 0.237938883184864 0.40728886476566 no 1346 0.405964248493043 414 5375804 SGTC_1403 3909-7815 62.9 µM 0.237777528481662 0.407354805986816 no 1347 0.406026824271014 448 6615483 SGTC_228 caffeine 993.056 µM 0.236687028692747 0.407800531946545 no 1348 0.406449799338463 426 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3192 9110362 49.47 µM 0.235845202757724 0.408144697749023 no 1349 0.406776395316255 438 16649480 SGTC_1355 1499-0035 1.68 µM 0.235557103949262 0.408262498197711 no 1350 0.406888181441864 440 1548538 SGTC_941 3237-0776 460 µM 0.235225514021807 0.408398091951433 no 1351 0.407016852083711 471 760008 SGTC_1410 3909-8106 77.9 µM 0.234983980106608 0.40849686690563 no 1352 0.407110583577173 454 1039210 SGTC_2300 7976697 71.57 µM 0.234323411444842 0.408767035201223 no 1353 0.407366956046133 424 2236109 SGTC_1985 st071382 65.5 µM 0.234006179597258 0.408896796386633 no 1354 0.407490090610183 434 6123237 SGTC_1978 st071761 42 µM 0.232738026942009 0.409415623842113 no 1355 0.407982419344458 415 5147680 SGTC_1068 loratadine 26.9 µM 0.232472139644221 0.409524423984668 no 1356 0.408085661930988 431 3957 A H1 histamine antagonist. SGTC_2081 5214970 32.255 µM 0.231225898139307 0.41003447434752 no 1357 0.408569655648611 430 2063512 SGTC_1406 3909-7906 11.9 µM 0.2311621186557 0.410060581535729 no 1358 0.408594428979246 455 X1406 SGTC_1460 k062-0059 9.15 µM 0.228755486944407 0.411045990969798 no 1359 0.409529482838824 410 1373085 SGTC_1290 0986-0249 10.2 µM 0.2267028255165 0.411886909232883 no 1360 0.410327414936887 448 53329 SGTC_1285 0929-0069 65.5 µM 0.226670204381503 0.411900276481967 no 1361 0.410340098773431 422 1206237 SGTC_2750 bromebric acid 70.15 µM 0.224465664852548 0.412803872629025 no 1362 0.41119749037913 429 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_764 1951-2361 146 µM 0.223812898507757 0.413071517258276 no 1363 0.411451446497126 447 5438930 SGTC_3204 9114183 49.47 µM 0.223389794216283 0.413245018368983 no 1364 0.411616073344098 405 17027248 SGTC_1260 0700-1617 7.75 µM 0.221983984223133 0.413821616163326 no 1365 0.412163175524503 443 2853078 SGTC_1989 st071868 50.2 µM 0.221259737524671 0.414118741047915 no 1366 0.412445098923558 467 16414057 SGTC_101 0490-5701 117.494 µM 0.218437267655328 0.415277137360952 no 1367 0.413544215572399 464 4661669 SGTC_1176 0848-0131 83.3 µM 0.218240951234265 0.415357736946661 no 1368 0.413620689757374 470 6769040 SGTC_695 3505-6186 243 µM 0.215441700894217 0.416507381868195 no 1369 0.414711480320858 438 1819379 SGTC_2012 4023501 200 µM 0.215274974360784 0.416575878671411 no 1370 0.414776469891461 456 3477460 SGTC_3045 9092950 49.47 µM 0.215251720562821 0.41658543230609 no 1371 0.414785534347034 438 44120432 SGTC_1914 st062367 72.6 µM 0.214535745187607 0.416879609080687 no 1372 0.415064647582794 435 978205 SGTC_2865 9030313 51.95 µM 0.213484352109616 0.417311685111594 no 1373 0.415474596507125 439 42562754 SGTC_656 4090-1979 187 µM 0.212532270485686 0.417703034712614 no 1374 0.41584590228822 453 22330961 SGTC_2575 plumbagin 510 nM 0.211704113311607 0.418043511939826 no 1375 0.416168939439475 462 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3331 9141060 1.957 µM 0.210966798391146 0.418346693226185 no 1376 0.416456589654007 430 4906567 YPR165W RHO1 SGTC_2028 5153890 36.43 µM 0.210327892959942 0.418609448123278 no 1377 0.41670588336084 449 2830968 YPR165W RHO1 SGTC_2350 9023895 38.85 µM 0.210186413330183 0.418667637652401 no 1378 0.416761091653878 457 2997209 SGTC_424 splitomicin 100 mM 0.209704524823882 0.418865848190541 no 1379 0.416949146880838 454 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1870 st057514 26.5 µM 0.20936837336885 0.419004126315575 no 1380 0.417080340011578 449 5393161 SGTC_2313 7726885 200 µM 0.208895760870384 0.419198555513788 no 1381 0.417264806748166 425 726423 SGTC_2833 9001315 45.46 µM 0.20821146557174 0.419480104369186 no 1382 0.417531928269505 418 2989378 SGTC_1744 st037937 38.9 µM 0.207512388758222 0.419767777556392 no 1383 0.41780485920611 421 1016152 SGTC_2869 9037858 32.47 µM 0.20655768389933 0.420160712046923 no 1384 0.418177655418084 437 27187042 SGTC_35 0133-0054 64.071 µM 0.205540850713032 0.420579304644355 no 1385 0.418574792546466 433 99677 SGTC_1184 1269-1718 139 µM 0.204453240888989 0.421027132776951 no 1386 0.418999664259076 438 5403821 SGTC_3090 9117696 49.47 µM 0.200328783352861 0.422726320235883 no 1387 0.420611726462196 471 7923821 SGTC_1530 rhein 70.4 µM 0.200297764087889 0.422739104993873 no 1388 0.420623855558571 458 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1842 st055362 61.2 µM 0.200098376304522 0.422821285690421 no 1389 0.42070182160426 434 676032 SGTC_143 4032-1194 15.74 µM 0.199667532683375 0.42299887588432 no 1390 0.420870303796121 437 1806963 SGTC_1046 2001-0062 216 µM 0.198532846691064 0.423466658892777 no 1391 0.421314094119119 461 739778 SGTC_2366 9070441 60.58 µM 0.19851429436228 0.423474308130923 no 1392 0.42132135100638 434 6837235 SGTC_2920 7982904 15.77 µM 0.196029743352726 0.424498963076373 no 1393 0.422293442896187 455 6456808 SGTC_2397 5161689 200 µM 0.195903696665971 0.424550959717861 no 1394 0.422342771906704 449 2259942 SGTC_2907 7721985 69.9 µM 0.195860508258283 0.424568776054672 no 1395 0.422359674189447 433 3267881 SGTC_301 4119-0100 24.5 µM 0.195844233865776 0.424575489703092 no 1396 0.422366043398229 467 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3099 9120367 49.47 µM 0.193786493620482 0.42542454156315 no 1397 0.423171531535589 475 24824940 SGTC_1380 2291-0730 164 µM 0.193473134405274 0.425553868325606 no 1398 0.423294222093404 423 2999191 SGTC_2134 5324836 1.464 µM 0.193080209286123 0.425716044120605 no 1399 0.423448075859713 483 699272 SGTC_172 1112-0046 2.638 µM 0.193073944991221 0.425718629745635 no 1400 0.423450528801723 443 2802135 YIL048W NEO1 SGTC_1886 st057356 49.9 µM 0.192186084536179 0.426085131692838 no 1401 0.423798222828386 438 24207747 SGTC_2067 5224629 34.075 µM 0.192079524688192 0.42612912307395 no 1402 0.423839956602813 432 2835000 SGTC_1700 st030840 7.9285 µM 0.191972989291193 0.426173105279832 no 1403 0.42388168165502 453 5499307 SGTC_2247 cerulenin 830 nM 0.191262863736194 0.426466297832633 no 1404 0.424159827201201 475 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2911 7942208 15.64 µM 0.19092099469941 0.426607461255749 no 1405 0.424293745664211 438 1243384 SGTC_1030 k029-0042 36.7 µM 0.190613917094055 0.42673426673275 no 1406 0.424414042925098 428 6080581 SGTC_2622 2-methoxyxanthone 59.94 µM 0.18958650344654 0.42715858475156 no 1407 0.424816582043584 459 71034 A hepatoprotective. SGTC_1082 camptothecin 424.86 nM 0.188237608597243 0.427715801216532 no 1408 0.425345196006782 502 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_867 0518-0118 155 µM 0.187732840476063 0.427924353574988 no 1409 0.425543042489881 481 6848158 SGTC_1654 st012436 41.8 µM 0.187702752497786 0.427936785501346 no 1410 0.425554836221603 468 4323132 SGTC_1268 0828-0275 2.46 µM 0.186626158929018 0.428381665693044 no 1411 0.425976877609964 454 745337 SGTC_3002 9075603 71.4286 µM 0.185974344613643 0.428651058856464 no 1412 0.426232440183738 477 20105405 SGTC_1640 st009078 66.4 µM 0.184960771469098 0.429070032004565 no 1413 0.4266299022312 472 690618 SGTC_659 k018-0002 107 µM 0.184957034452561 0.429071576895311 no 1414 0.426631367801052 453 6797879 YHR007C ERG11 SGTC_1972 st070201 17.4 µM 0.184142749597319 0.429408229893658 no 1415 0.426950735263134 469 2829099 SGTC_1262 0737-0114 49.6 µM 0.183052859961176 0.429858907578744 no 1416 0.427378271504907 481 765919 SGTC_2962 9082311 13.18 µM 0.182755317275147 0.4299819596598 no 1417 0.427495004847156 451 16459453 SGTC_862 0452-0056 10.2 µM 0.181887394491261 0.430340937575136 no 1418 0.427835548612562 465 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2275 7947463 200 µM 0.181413823376388 0.430536833643846 no 1419 0.428021384707842 481 1225414 SGTC_2557 derrustone 83.84 µM 0.180859453083796 0.430766174584935 no 1420 0.42823894784087 469 629853 An antioxidant. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.180300655468445 0.430997370724587 no 1421 0.428458270557296 471 5282309 SGTC_1161 k007-0610 110 µM 0.179795280825137 0.431206484085931 no 1422 0.428656644300476 471 5843850 SGTC_2073 5212005 126 µM 0.179568954334882 0.431300139466575 no 1423 0.428745489652175 484 691789 SGTC_830 4076-0286 57.8 µM 0.178785156306279 0.431624510031372 no 1424 0.429053200520854 449 6866659 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.178735272162724 0.431645155876757 no 1425 0.429072785972887 446 115019 SGTC_431 k089-0097 107 µM 0.178006559676616 0.431946773679483 no 1426 0.429358912070058 464 5499420 SGTC_1199 1638-0010 4.46 µM 0.177937293325692 0.431975445441765 no 1427 0.429386111164901 447 3111136 SGTC_2291 7917025 104.35 µM 0.177306443426774 0.432236592725736 no 1428 0.429633844930277 464 2964612 SGTC_2686 alizarin 95.37 µM 0.176734343126875 0.432473445568659 no 1429 0.429858531783478 425 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3313 9133968 57.047 µM 0.175380773601392 0.433033927683726 no 1430 0.430390223443989 484 1494643 SGTC_2610 ononetin 44.17 µM 0.174345886229978 0.433462541771435 no 1431 0.430796819707415 450 259632 SGTC_2385 9074692 200 µM 0.174048988331721 0.433585520947609 no 1432 0.430913481302299 433 17046906 SGTC_1444 4112-3581 28 µM 0.173777346063907 0.433698044528988 no 1433 0.431020224355838 460 2877249 SGTC_1738 st035555 74 µM 0.173463933016352 0.433827877681992 no 1434 0.431143387685867 474 5331140 SGTC_497 capsazepine 133 µM 0.172273003450493 0.434321292081045 no 1435 0.431611453579683 448 2733484 A calcium channel blocker. SGTC_903 1134-0042 114 µM 0.172224527923845 0.43434137816423 no 1436 0.431630507744695 441 701009 SGTC_3103 9120822 49.47 µM 0.172054781418914 0.434411714835128 no 1437 0.431697230870863 493 17141819 SGTC_748 act1.228 77.9 µM 0.17166852286375 0.434571773822587 no 1438 0.431849066754448 428 4421505 YNR035C ARC35 SGTC_3260 9137109 49.47 µM 0.170785532720039 0.434937710186948 no 1439 0.432196202578105 468 17478346 SGTC_1007 4101-0031 70 µM 0.168412367215873 0.435921493186416 no 1440 0.433129439716024 473 1146276 SGTC_405 ebelactone b 50 µM 0.168263928165403 0.435983041039427 no 1441 0.433187825184965 465 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1040 k898-0338 155 µM 0.167926954350017 0.436122767537588 no 1442 0.433320372364193 471 20969351 SGTC_1637 st007924 17.4 µM 0.16720507214779 0.436422123458704 no 1443 0.433604346803612 469 683336 SGTC_723 4182-0001 115 µM 0.167189863996941 0.436428430489388 no 1444 0.433610329764004 469 744821 YLR208W SEC13 SGTC_2215 7188065 200 µM 0.166421192472312 0.436747230230435 no 1445 0.433912748661134 476 940217 SGTC_2208 7283366 200 µM 0.165228219178709 0.437242086680038 no 1446 0.43438217741047 480 898663 SGTC_1981 st071826 47 µM 0.164797885063138 0.437420617425634 no 1447 0.434551534378733 459 11838600 SGTC_2984 9022109 38.96 µM 0.164398652271979 0.437586256702058 no 1448 0.43470866223555 477 6459207 SGTC_2506 ethyl hematommate 54.16 µM 0.164368393740313 0.437598811230592 no 1449 0.434720571643582 452 3940691 An allergen. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.16371043689836 0.437871818773067 no 1450 0.434979550474329 461 5377381 SGTC_2841 9004761 38.96 µM 0.162598490751081 0.438333268300995 no 1451 0.435417287692602 432 2991039 SGTC_535 2293-4129 48.2 µM 0.161854686465098 0.438641988490818 no 1452 0.435710143585547 487 396118 YIL048W NEO1 SGTC_3077 9117319 49.47 µM 0.16083074337337 0.439067042921477 no 1453 0.436113355359656 488 17154678 SGTC_174 3553-0389 74.3 µM 0.160488982979019 0.439208928551673 no 1454 0.436247949725315 457 738071 SGTC_1953 st076800 12.1 µM 0.160076126497815 0.439380340928757 no 1455 0.436410553472234 449 297591 SGTC_63 0099-0242 26.702 µM 0.157512588614378 0.440444940060505 no 1456 0.437420443726724 469 3898502 YLR359W ADE13 SGTC_319 1348-1596 45.5 µM 0.157243064545678 0.440556894546634 no 1457 0.437526644911918 471 5380505 SGTC_1124 fisetin 1.16336 µM 0.156207006327386 0.44098729495164 no 1458 0.437934927140223 449 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2047 4141938 200 µM 0.155420677749544 0.441313998964781 no 1459 0.438244841874217 487 3807862 SGTC_1322 1348-1070 12 µM 0.154183400372666 0.441828144084953 no 1460 0.438732565131702 481 6758089 SGTC_1697 st025554 27.742 µM 0.154127765710883 0.441851265131021 no 1461 0.438754497990524 471 1269519 SGTC_2589 lobaric acid 100 µM 0.153394675748391 0.44215594631615 no 1462 0.439043521668278 459 73157 A novel microtubule depolymerizer. SGTC_71 0417-1750 47.813 µM 0.153213668914856 0.442231180252448 no 1463 0.439114889352555 502 6811472 SGTC_2507 purpurin 79.67 µM 0.15316773546397 0.442250272428517 no 1464 0.439133000387178 497 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1659 st012954 42.1 µM 0.152585340620772 0.442492355666535 no 1465 0.439362643053818 472 24207262 SGTC_994 3910-0338 138 µM 0.151542902861244 0.442925717851717 no 1466 0.439773735008218 482 3479481 SGTC_2008 4012253 172 µM 0.151512255113649 0.442938459768044 no 1467 0.439785822127155 473 603940 SGTC_2139 5578692 56.4705 µM 0.151486140932311 0.442949316883715 no 1468 0.439796121304023 482 650991 YMR113W FOL3 SGTC_1452 4194-0072 190 µM 0.151419332914509 0.442977092882471 no 1469 0.439822469916104 470 1343545 SGTC_586 0957-0265 8.15 µM 0.151291770045998 0.443030129002812 no 1470 0.439872780554018 498 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2181 6316240 54.2555 µM 0.150637434867098 0.44330219440946 no 1471 0.44013086478799 445 12779990 SGTC_1358 1509-0022 2.48 µM 0.150100471496865 0.443525477877159 no 1472 0.44034267399962 443 3258434 SGTC_244 nsc-207895 1.295 µM 0.150089366870934 0.443530095661673 no 1473 0.440347054482638 468 42640 SGTC_3146 9095609 49.47 µM 0.148304951308135 0.444272232146818 no 1474 0.441051053996583 475 17173999 SGTC_476 mead acid 10 µM 0.147382683114519 0.444655879255199 no 1475 0.441414986564934 470 5312531 An omega 9 fatty acid. SGTC_194 1486-1323 56.904 µM 0.146429933106987 0.445052260702844 no 1476 0.441790999387646 488 5178754 SGTC_1649 st011737 51.3 µM 0.146163901410543 0.445162950174073 no 1477 0.441896000981663 484 1761035 SGTC_2937 9044753 11.33 µM 0.14594957289317 0.44525213029056 no 1478 0.441980598518054 479 6465530 YGL099W LSG1 SGTC_2560 caryophyllene 100 µM 0.145085639117517 0.445611633202382 no 1479 0.442321628319196 464 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2742 clothiapine 36.27 µM 0.143612171756177 0.446224880230014 no 1480 0.442903364313318 490 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_992 3909-8734 162 µM 0.143008945320472 0.446475976140438 no 1481 0.443141558234159 470 4288319 SGTC_1620 st003704 16.5 µM 0.142972608255846 0.446491102305045 no 1482 0.443155907181307 493 2834414 SGTC_2581 avocatin a 64 µM 0.142562345419667 0.446661889333698 no 1483 0.443317918824119 480 6710728 A skin care supplement. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.141157881419286 0.447246623961151 no 1484 0.443872609298836 492 91467 include heat shock SGTC_561 1550-0330 72.9 µM 0.140438402288302 0.447546216451129 no 1485 0.444156808927284 476 6812934 SGTC_2144 5628481 200 µM 0.140320704356881 0.447595228948469 no 1486 0.444203303225954 487 2818399 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.138898681885901 0.448187459323748 no 1487 0.444765106287166 501 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1457 k015-0032 57.3 µM 0.13840022259258 0.448395080309087 no 1488 0.444962060553081 478 4302660 SGTC_167 3672-0051 66.205 µM 0.138229383431186 0.448466242424434 no 1489 0.44502956668996 490 3237971 SGTC_377 3970-0964 33.1 µM 0.13702724832538 0.448967031964695 no 1490 0.445504628603898 476 16481235 SGTC_2798 7813637 45.45 µM 0.136243590963837 0.44929353445126 no 1491 0.445814357909633 497 956368 SGTC_1477 0139-0234 16 µM 0.134924226269878 0.449843311144346 no 1492 0.446335892449872 478 620880 SGTC_1792 st045773 43.6 µM 0.134883163159359 0.449860423612758 no 1493 0.446352125870639 488 2919270 SGTC_2146 5545642 200 µM 0.134240825966282 0.450128120636278 no 1494 0.446606071801414 478 825326 SGTC_1226 3909-7979 35.4 µM 0.133874769823963 0.450280686401453 no 1495 0.446750800714934 501 6615510 SGTC_2340 7987427 183.45 µM 0.133408237083673 0.450475139693342 no 1496 0.446935265694501 476 2239331 SGTC_202 3594-0513 34.79 µM 0.133228065662994 0.450550239270838 no 1497 0.447006507751737 484 708429 SGTC_1610 st001799 48.1 µM 0.13308971586286 0.45060790784027 no 1498 0.447061214172421 481 621897 SGTC_1848 st056003 16.4 µM 0.132652664399625 0.450790091548205 no 1499 0.447234040125305 492 146492 SGTC_582 0987-0078 156 µM 0.132042993822777 0.451044248372966 no 1500 0.447475142648622 498 1625765 SGTC_2234 tolnaftate 200 µM 0.130934080682607 0.451506578656823 no 1501 0.447913727133145 489 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2791 5663188 71.43 µM 0.130798481612001 0.451563117418924 no 1502 0.447967362087864 504 54690634 SGTC_72 0744-0168 198.391 µM 0.130484748653419 0.451693933828605 no 1503 0.448091459894844 496 677577 SGTC_1317 1273-0028 910 nM 0.13013552243822 0.451839555937111 no 1504 0.448229603117098 489 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2614 arthonioic acid 13.39 µM 0.129855119317874 0.451956484535719 no 1505 0.448340526570579 467 6710684 SGTC_524 r073-0010 27.8 µM 0.12948666446507 0.452110137197553 no 1506 0.44848628816602 483 2772106 SGTC_2396 5342950 42.78 µM 0.127556469077228 0.452915181973646 no 1507 0.449249991136563 484 1886677 SGTC_2985 9022375 71.43 µM 0.127500357230821 0.452938587981477 no 1508 0.449272195230306 464 4939335 SGTC_3136 9095672 49.47 µM 0.12723499683636 0.453049280323377 no 1509 0.449377203497526 495 17217380 SGTC_2867 9039098 71.43 µM 0.126881934484294 0.453196562283987 no 1510 0.449516922630005 477 6463460 SGTC_3345 9148410 3.559 µM 0.125425446321446 0.453804212417329 no 1511 0.450093371965115 506 4903596 SGTC_83 0170-0301 39.027 µM 0.124561913276862 0.454164531506842 no 1512 0.450435191147667 478 3089716 SGTC_3029 9088683 49.47 µM 0.124099374996208 0.454357546455737 no 1513 0.450618296507872 472 25236615 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.123901269542318 0.454440218186477 no 1514 0.45069672387285 498 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1896 st058441 89 µM 0.123133877319216 0.454760478565124 no 1515 0.451000542587711 431 688759 SGTC_991 3996-0057 64.7 µM 0.122479459612021 0.455033613855953 no 1516 0.451259656182096 458 715343 SGTC_331 k048-0133 24.5 µM 0.122370424521243 0.455079124063396 no 1517 0.4513028301318 482 6813582 SGTC_1375 2910-0797 186 µM 0.122276764759109 0.455118217225988 no 1518 0.45133991646779 510 742508 SGTC_84 0443-0269 128.823 µM 0.121048489618614 0.45563093381938 no 1519 0.451826314189582 507 6150058 SGTC_1026 k007-1105 30.6 µM 0.121023756185223 0.455641259012122 no 1520 0.451836109389899 465 7066794 SGTC_2603 homopterocarpin 100 µM 0.120978154155003 0.455660296065592 no 1521 0.451854169273251 474 101795 A weak amylase inhibitor. SGTC_3290 9121031 71.43 µM 0.120779472275607 0.455743239120828 no 1522 0.451932854905172 493 17014854 SGTC_517 1365-0151 113 µM 0.119593231561907 0.456238495052186 no 1523 0.452402690836287 477 768657 SGTC_2334 9017922 200 µM 0.115857912197649 0.457798432842491 no 1524 0.453882576098311 497 3163164 SGTC_3158 9100007 49.47 µM 0.113733343199836 0.45868598346006 no 1525 0.454724589978893 485 19297233 SGTC_446 go6976 132 µM 0.111460489418176 0.459635708840017 no 1526 0.455625597598974 498 3501 A protein kinase C inhibitor. SGTC_2695 st077686 51.995 µM 0.111404438288391 0.459659133068667 no 1527 0.455647820363125 480 2876092 SGTC_2534 helenine 20.12 µM 0.111332387912194 0.45968924371981 no 1528 0.455676386601629 492 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2435 5706476 10.6 µM 0.110764214357846 0.459926697835223 no 1529 0.455901661745416 494 5725375 SGTC_1362 1611-0397 101 µM 0.109546097077586 0.460435827955828 no 1530 0.456384680778768 490 27816 SGTC_2472 5377652 49.4 µM 0.108757337161609 0.460765536474875 no 1531 0.456697481519909 494 1610903 SGTC_690 glyoxal 20.3 µM 0.107329305235879 0.461362534737632 no 1532 0.457263868300521 496 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3125 9127534 49.47 µM 0.107295797386921 0.461376543968025 no 1533 0.457277159248276 508 1639235 SGTC_1974 st069448 26.9 µM 0.106928382094376 0.46153015904225 no 1534 0.457422898307486 497 6323587 YNR016C ACC1 SGTC_1781 st038725 66.3 µM 0.106410862120243 0.461746542099944 no 1535 0.457628187642295 468 4270275 YIL048W NEO1 SGTC_1282 0886-0010 32.4 µM 0.104868022290232 0.462391694103445 no 1536 0.458240266768629 518 2836211 YNL267W PIK1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.104690513582953 0.462465927305279 no 1537 0.458310694829862 516 688667 SGTC_2789 5281112 71.43 µM 0.102804144838825 0.463254876984523 no 1538 0.459059207796011 485 765948 SGTC_1731 st035964 63 µM 0.10068751539706 0.464140302210418 no 1539 0.459899261137488 482 6739575 SGTC_2298 7976326 193.81 µM 0.100313115797186 0.464296939098382 no 1540 0.460047872557524 509 2235818 SGTC_1545 lovastatin 49.4 µM 0.100112171984884 0.464381009883658 no 1541 0.460127636017642 504 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1088 bifonazole 369 nM 0.100031716365548 0.46441467131692 no 1542 0.460159572850837 509 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1015 4130-4525 82 µM 0.0984411521567948 0.465080191682832 no 1543 0.460790999327193 476 1363237 SGTC_2766 oltipraz 83.91 µM 0.0978402213030606 0.465331657371386 no 1544 0.461029584300859 481 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1216 1165-0504 9.65 µM 0.0977038241360128 0.465388736098455 no 1545 0.461083739433662 485 6304004 SGTC_3338 9144300 39.5675 µM 0.0974450621216001 0.465497023341511 no 1546 0.461186480289391 491 4901274 SGTC_427 1354-0053 47.3 µM 0.0973726018734945 0.465527347108659 no 1547 0.46121525092689 487 6813657 SGTC_493 zm226600 134 µM 0.0966889648914341 0.465813451026135 no 1548 0.461486701754664 502 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1001 4048-4355 44.4 µM 0.0962523399562891 0.465996188992967 no 1549 0.46166008123499 497 21824233 SGTC_2739 tacrine 100.86 µM 0.0952546446589689 0.466413775157711 no 1550 0.462056283549668 510 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3301 9125354 19.7965 µM 0.0934090340232271 0.467186354092809 no 1551 0.462789306893074 481 41905162 SGTC_1221 2958-7315 257 µM 0.0926605336722688 0.467499714306684 no 1552 0.463086625817085 489 4562705 SGTC_129 0088-0017 176.636 µM 0.0918218259939684 0.467850863804017 no 1553 0.463419801340701 513 182446 SGTC_1515 3460-0031 42.1 µM 0.090763012474051 0.468294202742445 no 1554 0.463840450235628 496 2876596 SGTC_677 0929-0063 136 µM 0.0893553336241643 0.468883676915347 no 1555 0.464399760010532 512 1539583 SGTC_302 1094-0063 18.9 µM 0.0892935357802505 0.468909556715013 no 1556 0.464424315624797 514 5440289 SGTC_2752 diclazuril 33.15 µM 0.089128131271465 0.468978825725151 no 1557 0.464490040417813 490 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1663 st014140 55.4 µM 0.0890245588879204 0.469022200815943 no 1558 0.464531196219046 503 4207120 SGTC_817 1391-0715 46 µM 0.0887326491433148 0.469144451709278 no 1559 0.464647192301759 508 1353946 SGTC_829 1635-0120 117 µM 0.0865595497138996 0.470054629657221 no 1560 0.465510809910299 506 285054 SGTC_2105 5350118 200 µM 0.0851154604300608 0.470659556847076 no 1561 0.466084799632371 492 2133313 SGTC_1269 0831-0796 3.05 µM 0.0844634712651555 0.47093269656096 no 1562 0.466343972366359 515 927758 SGTC_1564 D-Arginine 115 µM 0.0837817846733133 0.471218292125174 no 1563 0.466614965409306 504 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_165 k038-0023 64.381 µM 0.0829013053609077 0.471587194650476 no 1564 0.466965008044021 494 46368543 SGTC_590 k048-0076 22.4 µM 0.0828412517675441 0.471612356749152 no 1565 0.466988883835302 499 6832814 SGTC_171 k064-0041 9.68 µM 0.0824107429072909 0.471792740714473 no 1566 0.467160046752719 495 53325 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0816087706781912 0.472128783881952 no 1567 0.46747891328473 512 4213774 SGTC_369 0957-0393 4.5 µM 0.0815056730360319 0.472171985398508 no 1568 0.467519906730614 501 6997992 SGTC_1429 4049-0205 9.46 µM 0.0813201772561943 0.472249715439665 no 1569 0.467593664000476 493 22774478 SGTC_1206 3978-0017 132 µM 0.0809026540049741 0.472424677996565 no 1570 0.46775968464795 510 3873677 SGTC_2536 dehydroabietamide 32.04 µM 0.0804988747880741 0.47259388619582 no 1571 0.467920245560676 509 3983547 SGTC_2969 9091408 28.7 µM 0.0803346731794488 0.472662698133738 no 1572 0.467985541054762 470 4286311 SGTC_2470 5664817 21.68 µM 0.0796752330387099 0.472939057789325 no 1573 0.468247778993816 512 2859561 SGTC_1149 3909-7961 23.3 µM 0.0789641928976334 0.473237056680389 no 1574 0.468530552012824 520 735261 SGTC_1156 4092-0367 4.88 µM 0.0784131993749126 0.473467989900073 no 1575 0.468749687138631 508 1357585 SGTC_409 arachidonic acid 100 µM 0.0777436590758933 0.473748620613622 no 1576 0.469015982129811 492 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2044 5102272 200 µM 0.0776090336776714 0.473805048998724 no 1577 0.469069528111315 497 592666 SGTC_70 0141-0289 43.283 µM 0.0769590940215314 0.47407747930053 no 1578 0.469328043328096 503 352408 SGTC_3018 9082602 49.47 µM 0.0764751224922491 0.474280349876574 no 1579 0.469520552689061 505 17332089 SGTC_114 0364-0001 490.298 µM 0.0762027828204902 0.474394511813052 no 1580 0.469628884379277 462 4003655 SGTC_1603 st002045 67.8 µM 0.0752139715672752 0.474809028735549 no 1581 0.470022234069964 511 5887985 SGTC_245 methotrexate 289.6 µM 0.0745189556328847 0.47510040085459 no 1582 0.47029872934313 525 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1685 st024049 53.0905 µM 0.0738508186465293 0.475380517046106 no 1583 0.470564544979324 511 1941139 SGTC_833 3852-0053 558 µM 0.0737560709241848 0.475420240983062 no 1584 0.470602241047526 501 3123681 SGTC_2514 salinomycin 42.74 µM 0.0736943146323054 0.475446133062032 no 1585 0.470626811377778 510 23682228 A polyether potassium ionophore. SGTC_834 0312-0008 75.7 µM 0.0736763443591646 0.475453667337815 no 1586 0.4706339610435 514 6385573 YIL048W NEO1 SGTC_2551 apiole 73.87 µM 0.0735365110191443 0.475512294623228 no 1587 0.470689595559385 511 10659 A possible DNA adduct former. SGTC_958 1222-0007 33 µM 0.0730456910680529 0.475718082649104 no 1588 0.470884879191653 507 7312461 SGTC_678 1218-2179 85.9 µM 0.0719075698353574 0.476195292079319 no 1589 0.471337732894933 530 6820081 YOR116C RPO31 SGTC_155 k072-0202 43.6 µM 0.0716626771975656 0.476297979016249 no 1590 0.471435179522031 521 5857737 SGTC_3182 9108849 49.47 µM 0.0709921663118793 0.476579141722105 no 1591 0.471701995069276 514 17133045 SGTC_907 3448-6986 75.5 µM 0.0703086332727238 0.476865776958021 no 1592 0.471974005578151 496 590582 SGTC_3042 9091578 49.47 µM 0.0701808730149163 0.476919353742362 no 1593 0.472024848952968 508 25236497 SGTC_3235 9132602 49.47 µM 0.069755253937557 0.477097841840195 no 1594 0.472194231281025 512 4912240 SGTC_2419 paclitaxel 166.5 µM 0.0696053140977579 0.477160721877294 no 1595 0.472253903581883 522 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2571 chrysanthemic acid 100 µM 0.0688147599822099 0.477492264691701 no 1596 0.472568534586396 501 2743 An insecticide. SGTC_1531 st059297 52.4 µM 0.0685282784912785 0.477612413240151 no 1597 0.472682555000632 514 7566702 SGTC_3240 9133527 49.47 µM 0.0683011188983745 0.477707684001998 no 1598 0.472772966729405 515 17617455 SGTC_1798 st045719 60.953 µM 0.0676319974623596 0.477988320999226 no 1599 0.473039291707187 521 3980186 SGTC_2026 5148700 152 µM 0.0675244723933314 0.478033419234634 no 1600 0.473082090165365 519 79838 SGTC_2795 7780010 54.55 µM 0.0675131416997259 0.478038171578016 no 1601 0.473086600166313 506 953673 SGTC_1463 k081-0032 34.1 µM 0.0671824254104661 0.478176882673709 no 1602 0.473218238001102 522 977755 SGTC_696 1560-0013 611 µM 0.0665110280152532 0.478458492484276 no 1603 0.473485489032865 507 1650269 SGTC_444 curcumin 90.4 µM 0.0660005436869653 0.478672616389752 no 1604 0.473688696300257 503 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2909 7941780 10.49 µM 0.0656609821596579 0.478815049719524 no 1605 0.473823868534852 511 1243215 SGTC_1688 st021091 57.6 µM 0.0649903847167982 0.479096348134934 no 1606 0.474090827977453 528 3656366 SGTC_3231 9132313 49.47 µM 0.0635629938953149 0.479695136442201 no 1607 0.474659099360766 514 4905967 SGTC_3222 9128301 49.47 µM 0.0615650789761654 0.480533335411319 no 1608 0.475454593553093 530 4911358 SGTC_183 3914-0051 30.55 µM 0.0604577604384665 0.480997933675303 no 1609 0.475895528282734 517 1596232 SGTC_3016 9080866 49.47 µM 0.0585149834110289 0.481813127716916 no 1610 0.476669213954135 525 17066299 SGTC_2734 clemastine 41.6 µM 0.0583286811183452 0.48189130466932 no 1611 0.476743411085907 516 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2290 7904846 200 µM 0.0580838906999259 0.481994025713388 no 1612 0.476840903043451 503 2962154 SGTC_2143 5623677 140.463 µM 0.0576590446171998 0.482172306085361 no 1613 0.477010108526259 528 5375313 SGTC_645 0845-0943 5.41 µM 0.0568614439702634 0.482507016995487 no 1614 0.477327783924861 514 1885106 SGTC_536 3852-0578 10.6 µM 0.0568503832585579 0.482511658679848 no 1615 0.477332189384122 490 2869208 SGTC_1215 3852-0577 11.2 µM 0.0559681497651296 0.482881900069502 no 1616 0.477683590090012 510 2884876 SGTC_1368 1852-0141 284 µM 0.055904754068124 0.482908505515843 no 1617 0.477708841778186 515 2838987 SGTC_131 0141-0277 33.849 µM 0.0558752124667885 0.482920903346844 no 1618 0.477720608779396 509 1547771 SGTC_771 0250-0039 27.3 µM 0.0557922166463577 0.482955734592225 no 1619 0.477753667751991 528 3005115 SGTC_2391 6285546 200 µM 0.0550917336202634 0.483249714746391 no 1620 0.478032690879997 523 846083 SGTC_2102 5377816 72.7585 µM 0.0549173505738853 0.483322901603176 no 1621 0.478102154489511 524 1379702 SGTC_2759 disulfiram 3.38 µM 0.0545162981956586 0.48349122148689 no 1622 0.478261911908348 520 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_782 0083-0095 30.5 µM 0.0542516223033832 0.483602306384768 no 1623 0.478367346279584 498 3591729 An indicator and reagent. SGTC_1825 st052143 62.6 µM 0.0541789767060939 0.483632796081828 no 1624 0.478396285118608 521 674173 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0541407560433608 0.483648837511229 no 1625 0.478411510610173 527 97141 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0541162555884969 0.483659120505323 no 1626 0.478421270569201 520 5379071 SGTC_2020 4017018 200 µM 0.0516304906066627 0.484702466912497 no 1627 0.479411561871105 518 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2912 7964298 10.93 µM 0.0516294469364994 0.484702904993107 no 1628 0.479411977680688 535 2975850 SGTC_2926 9010726 65.15 µM 0.0510982180174158 0.484925890746609 no 1629 0.479623627977884 508 2994293 SGTC_618 k072-0232 33.2 µM 0.0502022473547139 0.485301989148872 no 1630 0.479980610341997 527 5872756 YGL099W LSG1 SGTC_116 0155-0182 31.788 µM 0.049839932763899 0.485454080381103 no 1631 0.480124972232645 513 771486 SGTC_3250 9135583 49.47 µM 0.0491669406336245 0.485736592412128 no 1632 0.480393128470823 504 7699353 SGTC_3225 9130819 49.47 µM 0.0489137616182013 0.485842875037107 no 1633 0.480494010902446 521 4547121 SGTC_1202 1988-0068 29.6 µM 0.0486018834647625 0.485973800495376 no 1634 0.480618284476501 525 2850480 SGTC_2127 5253358 187.912 µM 0.0472111413018305 0.486557647843661 no 1635 0.481172473974953 521 20612 SGTC_571 k831-0106 44.2 µM 0.0465749856391029 0.486824721977859 no 1636 0.481425984478524 528 4783639 SGTC_326 k292-0812 17.5 µM 0.0461525637259085 0.487002068584832 no 1637 0.481594325408549 525 3579357 SGTC_1887 st057648 70.8 µM 0.0458421861064996 0.487132376953806 no 1638 0.481718017243063 532 688672 SGTC_3283 9109332 35.8195 µM 0.0451597799231653 0.487418881922158 no 1639 0.48198997624724 529 17027281 SGTC_1446 4239-0190 62 µM 0.0446881352347615 0.48761690348976 no 1640 0.48217794548112 530 1340085 SGTC_973 1325-0077 65.9 µM 0.043763267632696 0.488005221000188 no 1641 0.482546553599264 534 2835149 SGTC_387 norethindrone acetate 66.7 µM 0.0428682258008187 0.488381026610106 no 1642 0.482903288796898 530 541197 SGTC_2086 5274770 176.623 µM 0.0416134391617262 0.488907897333434 no 1643 0.483403429810451 531 689278 SGTC_66 0109-0187 42.4 µM 0.038900988217689 0.490046889750945 no 1644 0.484484664341549 480 759417 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0383807722566963 0.490265344567152 no 1645 0.484692045600879 523 77254 SGTC_184 1494-0393 24.714 µM 0.038130638216634 0.490370384651965 no 1646 0.484791761651096 522 3090647 SGTC_3275 9138069 49.47 µM 0.0374699161294478 0.490647848297752 no 1647 0.485055163373026 531 17617007 SGTC_644 1498-1197 63.3 µM 0.0368243049150056 0.490918970655809 no 1648 0.485312547334355 524 6741615 SGTC_1427 4048-4900 550 nM 0.0359848152451502 0.491271517905233 no 1649 0.485647233395923 532 24132586 SGTC_1915 st067105 30.6 µM 0.0354438804889376 0.491498689381389 no 1650 0.485862897553224 535 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2427 5545055 42.75 µM 0.0339071740104117 0.492144060896802 no 1651 0.486475586223044 520 5372858 SGTC_1243 0416-0003 5.65 µM 0.0330583055081874 0.492500569621972 no 1652 0.486814045973167 528 2141977 SGTC_3311 9131146 2.8755 µM 0.0315471002135147 0.493135261921923 no 1653 0.487416615140444 514 4900406 YPR165W RHO1 SGTC_922 1866-0035 480 µM 0.030537722545961 0.493559201021914 no 1654 0.487819104579409 529 3156169 SGTC_97 0535-0701 19.132 µM 0.0299095986883992 0.493823017042946 no 1655 0.488069575314566 515 2832013 YGL099W LSG1 SGTC_1917 st066507 28.5 µM 0.0291647995045115 0.494135840935988 no 1656 0.488366577605053 529 3156428 SGTC_3185 9108267 49.47 µM 0.0284448750390917 0.494438220601827 no 1657 0.488653666780477 523 4910486 SGTC_5 0352-0601 109.883 µM 0.0283039546251875 0.49449740978469 no 1658 0.488709863265052 518 762456 SGTC_3050 9093513 49.47 µM 0.0272626320206463 0.494934788226728 no 1659 0.489125130555077 537 25236664 SGTC_621 3584-0052 32.1 µM 0.0269431165337166 0.495068993017705 no 1660 0.489252551983208 536 2273927 SGTC_2113 5491891 107.031 µM 0.0259572268390462 0.495483095709137 no 1661 0.489645727491179 533 789979 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.025177952790713 0.495810417213467 no 1662 0.489956511252686 520 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1456 k015-0012 13 µM 0.0251362440324071 0.495827936386649 no 1663 0.489973145375305 527 2989616 SGTC_1563 conessine 56.1 µM 0.0244718832416098 0.496106992789263 no 1664 0.490238105459556 538 441082 An anti-amoebic, histamine inhibitor. SGTC_1764 st044502 93.5 µM 0.0242202554336205 0.496212686393121 no 1665 0.490338460684584 526 8407 SGTC_1829 berberine 14.4 µM 0.019264768761996 0.498294230997135 no 1666 0.492314944582411 536 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1308 1187-1617 41.4 µM 0.0191699904323458 0.498334043122848 no 1667 0.492352748684043 537 2882570 SGTC_311 1315-0136 58 µM 0.0190805184431914 0.498371626308126 no 1668 0.492388436315991 535 6759207 SGTC_1812 st052057 4.327 µM 0.0182779731365789 0.498708740342459 no 1669 0.492708549711218 535 3645418 SGTC_2744 captopril 92.04 µM 0.0181632027649619 0.49875695041567 no 1670 0.49275432886523 538 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1969 st069479 40.1 µM 0.0176644114546171 0.498966471291185 no 1671 0.492953285880301 541 3895485 SGTC_2684 capsaicin 100 µM 0.0175494971321664 0.499014741920907 no 1672 0.492999122956717 538 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_628 1636-0253 16 µM 0.0174773780525023 0.499045036092842 no 1673 0.493027889894769 535 4456143 SGTC_294 k038-0071 157 µM 0.0168781001603745 0.499296767559174 no 1674 0.493266931909843 532 24152826 SGTC_940 3232-1287 54.8 µM 0.0165032052565955 0.499454245307342 no 1675 0.493416472505989 538 1585493 YIL048W NEO1 SGTC_1165 k072-0275 30.3 µM 0.0161816019858058 0.499589337526866 no 1676 0.493544756515854 541 6153523 YGL055W OLE1 SGTC_587 k089-0003 57 µM 0.0161086483855506 0.499619982321126 no 1677 0.49357385699851 540 9659696 SGTC_451 chloral hydrate 100 µM 0.0153331868235592 0.4999457217971 no 1678 0.493883183167747 535 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3014 9081533 49.47 µM 0.0150747554338566 0.4999457217971 no 1679 0.49398627045984 538 21367265 SGTC_3137 9097352 49.47 µM 0.0138465295180856 0.4994297947599 no 1680 0.494476210448335 542 44120435 SGTC_2203 7227154 166.4 µM 0.0123849958694878 0.498815866082932 no 1681 0.495059227814682 540 896304 SGTC_2318 6029776 164 µM 0.011392949799214 0.498399150856083 no 1682 0.495454968950461 545 818325 SGTC_2545 solidagenone 89.61 µM 0.0113637285212159 0.498386876297678 no 1683 0.49546662579913 542 6708572 An anti ulcer agent SGTC_929 2805-0021 398 µM 0.0108134088251316 0.498155711783205 no 1684 0.495686158094006 542 3098024 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.00993085784996955 0.497784993199616 no 1685 0.496038226042735 541 616764 SGTC_687 k029-0044 34.9 µM 0.00628988075834028 0.49625561195261 no 1686 0.497490717172451 543 5829338 SGTC_317 4495-0002 170 µM 0.00592900857476448 0.496104031329849 no 1687 0.497634681656734 544 15991618 SGTC_2645 abamectin 100 µM 0.00590658532389705 0.496094612693919 no 1688 0.497643627082932 545 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1734 st037168 69.4 µM 0.0046445632889452 0.495564518107333 no 1689 0.498147093991847 536 708907 SGTC_2623 humulene 100 µM 0.00348979373094523 0.495079480251986 no 1690 0.498607776556749 546 6187145 An anti-inflammatory. SGTC_537 1334-0398 209 µM 0.00263913312544049 0.494722181892037 no 1691 0.498947139434854 544 5846986 SGTC_777 1315-0167 517 µM 0.00214346195826487 0.494513989754234 no 1692 0.499144883053212 547 4221767 SGTC_3299 9121982 43.1275 µM 0.00120056077830953 0.494117955936775 no 1693 0.499521045660397 546 17594604 YPL160W CDC60 SGTC_527 4476-4215 268 µM 0.000922162092189208 0.494001025055727 no 1694 0.499632110604183 547 4418754 SGTC_2406 ethylparaben 405.7 µM 0.000876248870279188 0.493981740985622 no 1695 0.499650427322226 544 8434 A possible steroid mimic. SGTC_1219 1469-0211 33.1 µM 0.000154391846360895 0.493678554786597 no 1696 0.499938406564982 548 6822282 SGTC_3120 9124077 49.47 µM 1.84417263099106e-05 0.493621454962599 no 1697 0.499992642815652 548 18774327 YGL155W CDC43 SGTC_2257 7960413 200 µM -0.000114806460596315 0.49356549009271 no 1698 0.499954198848906 548 2974689 YIL048W NEO1 SGTC_1097 itavastatin 7.23 µM -0.000741874471379057 0.493302120275545 no 1699 0.499704034933765 549 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2022 5136654 200 µM -0.000902219314880712 0.493234775585128 no 1700 0.49964006661793 549 1713771 SGTC_708 3448-5400 146 µM -0.00158863608350336 0.492946483361364 no 1701 0.499366226164702 549 3462195 SGTC_820 1582-0060 59.9 µM -0.00167820891447446 0.492908863408751 no 1702 0.499330491822935 552 3848840 SGTC_2101 5377231 179.231 µM -0.0017544949679634 0.492876823858 no 1703 0.499300058135628 549 2844213 SGTC_1799 st045822 46.1415 µM -0.0018073843491301 0.492854610755108 no 1704 0.49927895835876 549 3674992 SGTC_395 anisomycin 6.25 µM -0.00235619279570826 0.49262411706468 no 1705 0.499060015942758 554 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1076 itraconazole 331 nM -0.00312907592380639 0.492299518593372 no 1706 0.49875168135248 551 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1324 1418-0026 34.4 µM -0.00417385478460361 0.491860736436928 no 1707 0.498334877688868 562 1372513 SGTC_1225 1216-0074 20.6 µM -0.00460437021072043 0.491679933080153 no 1708 0.498163128538673 549 4241466 SGTC_230 MPP+ 141.667 µM -0.00525279064924587 0.491407619497941 no 1709 0.497904449356595 554 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1789 tunicamycin 25 nM -0.00576803580757407 0.491191237658325 no 1710 0.49769889940119 550 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_552 k242-0005 476 µM -0.00584020551592297 0.491160929545549 no 1711 0.49767010833813 551 4088318 SGTC_2540 epiandrosterone 100 µM -0.00584735885045929 0.491157925461503 no 1712 0.497667254619265 551 441302 A steroid. SGTC_100 0086-0128 49.5915 µM -0.00618067185410402 0.491017949304557 no 1713 0.4975342843748 551 93297 SGTC_967 1306-0166 352 µM -0.00697422793671039 0.490684696670819 no 1714 0.497217708157953 552 4437607 SGTC_1994 st072947 40.9 µM -0.00723059970570732 0.490577035126526 no 1715 0.497115433199705 550 5286565 YDL195W SEC31 SGTC_1754 st042065 16.137 µM -0.00728416208300782 0.490554542064521 no 1716 0.497094065465486 556 1126236 YIL048W NEO1 SGTC_1483 3453-0561 55.9 µM -0.00735099363742215 0.490526476767263 no 1717 0.497067404246593 557 4546991 SGTC_3280 9140961 49.47 µM -0.00740397534993842 0.490504227617187 no 1718 0.497046268176582 557 4901226 SGTC_2502 avocadyne acetate 18.59 µM -0.00747534200695438 0.490474257936861 no 1719 0.497017797787601 550 3952079 SGTC_313 3474-0040 5.03 µM -0.00772671571257167 0.490368696610791 no 1720 0.496917517085446 551 1043375 YIL048W NEO1 SGTC_1058 3448-5425 97.3 µM -0.00805306111692756 0.490231652840436 no 1721 0.496787328158427 554 7279705 SGTC_1151 3909-8316 15.3 µM -0.00812899473086526 0.490199765843296 no 1722 0.49675703602088 553 800431 SGTC_2376 9072922 81.32 µM -0.00893062091781972 0.489863140764323 no 1723 0.496437245084215 566 17087968 SGTC_1254 0550-0035 264 µM -0.00992735568863463 0.489444594274507 no 1724 0.496039623134095 554 15121435 SGTC_2698 st077697 67.5 µM -0.0107187370180841 0.489112287567912 no 1725 0.495723924491801 552 3154499 SGTC_3040 9091894 49.47 µM -0.0119256977607715 0.488605490710638 no 1726 0.495242447711852 547 25236966 SGTC_2495 cafestol 54.53 µM -0.0135513148191808 0.487922931359546 no 1727 0.494593973022888 560 16667697 An anti-infammatory. SGTC_2812 7970281 58.44 µM -0.0143662234331445 0.487580783091962 no 1728 0.494268903202129 560 2233435 SGTC_2897 9048598 12.99 µM -0.0143864709064523 0.487572282084843 no 1729 0.494260826463647 554 6467404 SGTC_599 1935-0052 86.5 µM -0.0147003308327603 0.48744050708474 no 1730 0.494135627710559 559 9557311 SGTC_2607 solasodine 47.35 µM -0.0147872488757189 0.487404014534215 no 1731 0.494100956196944 559 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1760 st045453 10.4495 µM -0.0152385794203914 0.487214525054637 no 1732 0.493920921651685 558 3323419 YIL048W NEO1 SGTC_1629 st005085 44.9 µM -0.0156735839631501 0.487031892718485 no 1733 0.49374740067627 556 24207091 SGTC_1080 nisoldipine 24.4 µM -0.018101631141803 0.48601255225832 no 1734 0.492778888351256 556 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2930 9013230 14.89 µM -0.0203258096119492 0.485078879799705 no 1735 0.491891733472475 560 2995857 SGTC_3141 9094609 49.47 µM -0.0208205798702756 0.484871194565012 no 1736 0.491694390467115 561 25236309 YDL196W YDL196W SGTC_1682 st012968 530 nM -0.0214289036485187 0.484615849627476 no 1737 0.491451758539401 563 24207270 SGTC_728 3030-5151 22.5 µM -0.0221742007705671 0.484303018506432 no 1738 0.491154498666178 567 3125388 SGTC_2683 piperine 63.03 µM -0.0223965327108249 0.484209698728182 no 1739 0.491065823077657 560 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1205 4161-2785 76 µM -0.0228081182523234 0.484036945487789 no 1740 0.490901666140692 583 3498106 SGTC_2367 9070478 135.38 µM -0.0228168552941503 0.48403327835468 no 1741 0.490898181472147 558 572802 SGTC_259 usnic acid 108.925 µM -0.0255746031707503 0.482875858612659 no 1742 0.48979832158834 573 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1294 1000-1494 117 µM -0.0265029585373432 0.482486262214597 no 1743 0.489428086928838 568 712797 YDL207W GLE1 SGTC_2459 5811157 9.22 µM -0.0272005008221427 0.482193540510152 no 1744 0.489149908128379 558 2870684 YBR192W RIM2 SGTC_3008 9078912 71.4286 µM -0.0296978922548416 0.481145596870168 no 1745 0.48815399645936 564 16648731 SGTC_2323 6148992 148.28 µM -0.0301101065909921 0.480972637763 no 1746 0.487989620246326 565 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3043 9092303 49.47 µM -0.0304183492335704 0.480843305996732 no 1747 0.487866705527196 566 25236084 SGTC_917 harmaline 728.087 nM -0.0304269978151702 0.48083967727301 no 1748 0.487863256838647 563 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2177 5811945 192 µM -0.0304344111207405 0.48083656684079 no 1749 0.487860300726656 557 5343475 SGTC_3151 9099821 49.47 µM -0.0307776435843174 0.480692556613573 no 1750 0.487723434903701 577 17174189 SGTC_275 trichlorophene 5.69 µM -0.0309460827505392 0.480621885423589 no 1751 0.487656269392366 559 62616 SGTC_112 phenothiazine 287.218 µM -0.031304733056478 0.480471410315957 no 1752 0.487513257913114 564 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1047 2043-3044 82 µM -0.031997875798968 0.48018060366659 no 1753 0.48723687244917 569 669592 SGTC_1630 st005209 31.3 µM -0.0323801075649309 0.480020243597053 no 1754 0.487084463016281 557 3367314 SGTC_1641 st009299 47.1 µM -0.0325715441079276 0.479939930247473 no 1755 0.487008131148817 568 4046054 SGTC_1374 2889-5571 141 µM -0.032672626129234 0.479897523647693 no 1756 0.486967826708454 561 2853281 SGTC_2772 vinpocetine 57.06 µM -0.0328744162635231 0.479812867993583 no 1757 0.486887367314726 556 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1439 4092-1168 46 µM -0.0329172879221231 0.479794882452936 no 1758 0.486870273249045 566 2886240 SGTC_2701 st077767 14.721 µM -0.0342359304298691 0.479241705126594 no 1759 0.48634450749277 573 5721188 SGTC_69 0096-0274 206.684 µM -0.0344700670359953 0.479143487763182 no 1760 0.486251155601279 568 6741392 SGTC_3349 9149703 23.001 µM -0.0351987054777575 0.478837841225045 no 1761 0.485960647236068 567 4910494 SGTC_2852 9023854 51.95 µM -0.0354527390731955 0.478731283075629 no 1762 0.485859365709143 559 19798528 SGTC_2172 5754775 163.918 µM -0.0376041194790152 0.477828916453373 no 1763 0.485001661688711 567 2263357 SGTC_2711 st079103 59.1 µM -0.0379720459693043 0.477674606051114 no 1764 0.484854985016559 569 54693780 SGTC_1247 0448-0043 5.84 µM -0.0391804944447031 0.477167799760054 no 1765 0.484373242436176 581 3089013 YGL099W LSG1 SGTC_1025 k007-0731 70 µM -0.0395711874483984 0.477003956469694 no 1766 0.484217499262681 561 6256118 SGTC_231 b-estradiol 524 µM -0.041146963371741 0.476343169654049 no 1767 0.48358936746353 567 450 A steroid. SGTC_1014 4130-3005 69.3 µM -0.0434410656766511 0.475381276203252 no 1768 0.482674971453033 576 743608 SGTC_3065 9113888 49.47 µM -0.0467150259569783 0.47400878824357 no 1769 0.481370177219349 583 16648368 SGTC_882 0843-0131 351 µM -0.0483022569769168 0.473343509767213 no 1770 0.480737677923887 584 5425421 SGTC_2399 5884133 200 µM -0.0483440140884959 0.473326008516865 no 1771 0.480721038685272 573 722445 SGTC_2390 9097792 176.6 µM -0.0483687479786992 0.473315642067311 no 1772 0.48071118282063 571 4497149 SGTC_807 1315-0151 48 µM -0.0495001725821201 0.47284145966639 no 1773 0.480260349834663 579 4011080 SGTC_1907 st060210 83.7 µM -0.0517412168555603 0.471902347610164 no 1774 0.479367447452497 580 688793 SGTC_2941 9056145 11.23 µM -0.0529035006511367 0.471415352493128 no 1775 0.478904397594053 573 2119517 SGTC_2160 5660466 132.927 µM -0.0547402753348862 0.470645834157077 no 1776 0.478172691185683 586 2859134 SGTC_2338 7999974 200 µM -0.0558022106121767 0.470200985272748 no 1777 0.477749686938095 580 315925 SGTC_1195 1502-0147 41.1 µM -0.0563726766238721 0.469962030124718 no 1778 0.477522461613665 571 817940 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0571185812403313 0.469649604094623 no 1779 0.47722536744863 581 5393153 SGTC_246 cycloheximide 667 µM -0.0576675815188613 0.469419664397617 no 1780 0.477006708452665 569 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1255 0566-0045 221 µM -0.0590682715009373 0.468833054920117 no 1781 0.476448865086912 589 2788469 SGTC_2069 5228469 200 µM -0.0590803226958177 0.468828008167012 no 1782 0.476444065737375 567 2835210 SGTC_1594 piperine 70.1 µM -0.059956068283997 0.468461280252123 no 1783 0.47609531206909 571 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2217 6934799 96.0675 µM -0.0611115688683333 0.467977442913047 no 1784 0.475635177874097 588 675606 SGTC_1889 st059080 5.18 µM -0.0619942468333995 0.467607875138362 no 1785 0.475283706776198 607 176925 Isolated from Daphnopsis sellowiana. SGTC_1297 1068-0111 14.1 µM -0.0626612692565492 0.467328618523532 no 1786 0.475018119705482 571 767057 SGTC_3128 9127691 49.47 µM -0.0631670377247701 0.467116883444172 no 1787 0.474816746213532 579 41316314 SGTC_889 0919-1524 82.7 µM -0.0634312210045266 0.467006289363853 no 1788 0.474711563267438 595 3905452 SGTC_1859 st055998 20 µM -0.0645458172847453 0.466539718142187 no 1789 0.474267813113471 602 676301 SGTC_1713 st033146 12.748 µM -0.0657852652525248 0.466020937886593 no 1790 0.473774393723813 590 674619 SGTC_1245 0418-0076 17.2 µM -0.0663338198264751 0.465791354627433 no 1791 0.473556029090754 582 6790114 SGTC_1120 ficusin 1.78878 µM -0.0680042775097721 0.465092298419731 no 1792 0.472891114604545 593 6199 A DNA cross-linker. SGTC_1623 st003709 20.3 µM -0.0685197870664541 0.464876588681247 no 1793 0.47268593464506 568 16192618 SGTC_1148 3909-7663 27.7 µM -0.0686828178706975 0.46480837224222 no 1794 0.472621047627742 618 4084526 SGTC_3219 9131112 49.47 µM -0.0694046911268398 0.464506333664829 no 1795 0.472333747473416 579 17612988 YMR079W SEC14 SGTC_3140 9094243 49.47 µM -0.0696237540903872 0.464414679692078 no 1796 0.472246564893051 578 19291112 SGTC_285 1486-1325 46 µM -0.0699729664142904 0.464268576304281 no 1797 0.47210758827947 585 22310230 SGTC_410 α-linolenic acid 100 µM -0.0702543369571471 0.464150860052335 no 1798 0.471995613242758 570 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1466 k213-0079 57.5 µM -0.0734208551725272 0.46282631096986 no 1799 0.470735611176879 583 3657981 SGTC_1806 st050005 60.3 µM -0.0736967452780598 0.462710925920298 no 1800 0.470625844320047 573 5194765 SGTC_1951 sophoraflavanone G 9.2 µM -0.0749009352184907 0.462207336470079 no 1801 0.470146766226275 596 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_328 k915-0120 63.5 µM -0.0750948217793286 0.462126259199214 no 1802 0.470069633907366 584 6624543 SGTC_2569 tetrandrine 100 µM -0.0766380592951817 0.461480982124302 no 1803 0.469455740517176 589 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_964 1287-0107 19.4 µM -0.0777595255638466 0.461012124641659 no 1804 0.469009671420879 595 51516812 YPR165W RHO1 SGTC_1511 0906-3109 28.5 µM -0.0779695603221308 0.460924320276951 no 1805 0.468926133300922 584 2882180 SGTC_1077 5-fluorocytosine 377 nM -0.0784431495492313 0.460726344799182 no 1806 0.468737775438488 594 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_640 3381-0960 37.1 µM -0.0785819696089373 0.460668315407024 no 1807 0.468682564675552 598 1745025 SGTC_2808 7946468 45.46 µM -0.0793701681968558 0.460338849509345 no 1808 0.468369098047575 609 2970879 SGTC_3064 1327-0027 10 µM -0.080011592558452 0.460070755114897 no 1809 0.46811401800203 579 16000455 YPR107C YTH1 SGTC_601 0986-0029 62.9 µM -0.0801207305144363 0.460025140824218 no 1810 0.468070617591321 591 24747981 SGTC_521 r062-0005 13.8 µM -0.0810446572265369 0.459639006100022 no 1811 0.46770321897789 579 2832033 SGTC_21 0849-0113 22.993 µM -0.0818234802285103 0.459313543814677 no 1812 0.467393542077817 581 1560156 SGTC_1832 st054113 55 µM -0.0826704110671611 0.458959650904267 no 1813 0.467056806430261 576 1251267 SGTC_1745 st081495 74 µM -0.0831451372620823 0.458761299166529 no 1814 0.466868067863272 583 13842402 YBL026W LSM2 SGTC_844 0330-0132 15.3 µM -0.0868735447742318 0.457203843920014 no 1815 0.465386014105835 588 2828079 SGTC_2995 9067767 71.4286 µM -0.0870981671858082 0.45711003389496 no 1816 0.465296741112413 602 11673567 SGTC_1318 1280-3875 124 µM -0.08735333074939 0.457003471736781 no 1817 0.465195332090185 599 373245 SGTC_3173 9105693 49.47 µM -0.0880632547384559 0.456707007481929 no 1818 0.464913200673133 611 17096658 SGTC_3123 9126162 49.47 µM -0.0882929721869 0.456611082628307 no 1819 0.464821912262398 575 25239884 SGTC_2072 5231554 129 µM -0.0883203557974444 0.456599648015349 no 1820 0.464811030294343 588 789545 SGTC_2218 6965428 192.983 µM -0.0890711416701351 0.456286155329712 no 1821 0.464512685912281 584 675684 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0893388845123439 0.456174365148453 no 1822 0.46440629611602 604 23847180 SGTC_3159 9100096 49.47 µM -0.0903493626414921 0.455752493380618 no 1823 0.464004797400436 574 25236875 SGTC_2158 5657123 3.6195 µM -0.0912012005887519 0.455396892172721 no 1824 0.463666360499561 648 2858827 SGTC_1739 st037196 92.5 µM -0.0929231245722959 0.454678181473442 no 1825 0.462982317238259 600 612214 SGTC_211 3455-0679 143.504 µM -0.0931688913895547 0.454575613354227 no 1826 0.462884693969582 595 748649 SGTC_1716 st033144 30.6155 µM -0.0932616075012265 0.454536920075691 no 1827 0.462847865941536 591 674617 SGTC_635 k038-0028 24.7 µM -0.0938242158884257 0.4543021355957 no 1828 0.462624397518654 595 4035102 SGTC_3323 9138564 53.9225 µM -0.0943624939510071 0.45407751945041 no 1829 0.462410604157445 590 43912313 YNL103W MET4 SGTC_3253 9135987 49.47 µM -0.0946502757995453 0.453957438002893 no 1830 0.462296307370722 600 4182430 SGTC_1196 1588-0294 184 µM -0.0949898987541097 0.453815730463513 no 1831 0.46216142513326 604 6144269 SGTC_3212 9128307 49.47 µM -0.0972459882473279 0.45287452814989 no 1832 0.461265523871519 631 27243542 SGTC_371 0195-0006 7.36 µM -0.09742270621931 0.452800815516519 no 1833 0.461195356770053 588 3928593 SGTC_1160 4092-0570 10.5 µM -0.0974807626190018 0.4527765993751 no 1834 0.461172305335757 594 4994975 SGTC_1490 4089-0339 670 nM -0.0978037640842214 0.45264187412728 no 1835 0.461044059204727 595 742542 SGTC_758 0868-0029 16 µM -0.0979349694740727 0.452587149372448 no 1836 0.460991965911248 580 762687 SGTC_159 3970-0959 50 µM -0.0982311765003646 0.45246360702264 no 1837 0.460874363452665 599 6615653 SGTC_2011 4012611 177 µM -0.10012609372092 0.451673382274217 no 1838 0.460122109814932 601 2049887 SGTC_1937 st074714 47.2 µM -0.101623600716455 0.451049022145538 no 1839 0.459527722882698 615 17250970 SGTC_1569 carminic acid 40.6 µM -0.102104989164796 0.45084834104711 no 1840 0.459336670466827 576 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_358 0075-0058 9.45 µM -0.102347639531357 0.450747189781125 no 1841 0.459240371466185 655 1069125 SGTC_2917 7979103 53.79 µM -0.103193436033656 0.450394635980792 no 1842 0.458904724693493 616 2980565 SGTC_720 r052-1644 49.9 µM -0.105394340958534 0.449477415747313 no 1843 0.458031453158755 609 1422863 YOR257W CDC31 SGTC_3107 9121808 49.47 µM -0.105680879479565 0.449358021467212 no 1844 0.457917775674805 592 662681 SGTC_2041 5107442 45.335 µM -0.105792342734042 0.449311578426242 no 1845 0.457873556154336 595 793005 SGTC_68 0986-0284 82.829 µM -0.106840780702322 0.448874763172582 no 1846 0.457457647147774 583 423278 YIL048W NEO1 SGTC_3177 9107506 49.47 µM -0.106942987454276 0.448832183636849 no 1847 0.457417104831675 582 8897194 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.107098714408476 0.448767308611825 no 1848 0.45735533352801 607 390807 SGTC_904 1141-0088 396 µM -0.107351875320621 0.448661846039888 no 1849 0.457254915863294 624 1378119 SGTC_1489 4065-0444 182 µM -0.109325387685361 0.447839838965336 no 1850 0.456472205409061 591 2877968 SGTC_1138 3761-0006 1.03 µM -0.109676898782006 0.447693451011266 no 1851 0.456332810985876 597 12061087 SGTC_573 3702-0553 84.7 µM -0.110110323292797 0.44751295975591 no 1852 0.456160940569732 607 1222756 SGTC_332 4112-0506 40.9 µM -0.110158494774223 0.44749290034448 no 1853 0.456141839127401 595 2790355 SGTC_674 0498-0004 451 µM -0.110979070639999 0.447151219485128 no 1854 0.455816471703009 598 4231473 SGTC_2293 7624732 200 µM -0.111964411822477 0.446740983585985 no 1855 0.455425812173689 583 894453 SGTC_1579 chlormadinone acetate 49.4 µM -0.113110251372515 0.446263997662457 no 1856 0.454971573866486 628 45114258 A steroidal progestin. SGTC_2295 7971645 200 µM -0.114411287256096 0.445722501462957 no 1857 0.454455883407118 617 2978226 YKL099C UTP11 SGTC_2066 5222451 176 µM -0.115715320719942 0.445179859237703 no 1858 0.453939081822057 614 2281147 SGTC_110 0850-0284 111.64 µM -0.115937319441621 0.445087490000575 no 1859 0.453851109238081 584 3906265 SGTC_1573 oleylamine 1.06 µM -0.116708455110315 0.444766659036213 no 1860 0.45354554492987 615 5356789 An amine of the fatty acid oleic acid. SGTC_1547 harmine 94.2 µM -0.117338844225676 0.444504412537757 no 1861 0.453295772192145 583 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1476 4112-3294 3.34 µM -0.117575390140343 0.444406013962858 no 1862 0.45320205274555 592 704369 SGTC_2709 st078560 56 µM -0.118148622735287 0.444167574394521 no 1863 0.45297494892181 622 17250903 SGTC_1013 4112-3890 241 µM -0.118637077116354 0.443964414779079 no 1864 0.452781444743625 591 705171 SGTC_1079 idarubicin 2.36 µM -0.119446235663301 0.443627899215664 no 1865 0.452460916351728 612 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2058 5236698 133 µM -0.120783804128074 0.443071716010394 no 1866 0.451931139305578 605 766665 SGTC_3013 9080133 71.4286 µM -0.121344395187419 0.44283864621651 no 1867 0.451709128759408 602 17050193 SGTC_218 alverine citrate 93.75 µM -0.124206503237839 0.441649014028002 no 1868 0.450575886637502 599 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1130 3454-2858 15.9 µM -0.125768472408939 0.441000004434021 no 1869 0.44995759946864 588 715628 YIL048W NEO1 SGTC_3095 9117207 49.47 µM -0.12637871091775 0.440746488819675 no 1870 0.449716076626012 593 17015229 SGTC_2844 9010103 25.97 µM -0.12648870189796 0.440700797084064 no 1871 0.449672545897575 645 2480525 SGTC_2522 biochanin a 4.94 µM -0.127309397043933 0.44035989422184 no 1872 0.449347761530914 626 5280373 A possible chelator. SGTC_2763 lisinopril 49.32 µM -0.127316682299191 0.440356868247769 no 1873 0.449344878593703 633 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2167 5876490 200 µM -0.128552451720198 0.439843634623235 no 1874 0.448855896023286 601 686534 SGTC_1717 st033143 58.0435 µM -0.129439918224886 0.439475118745185 no 1875 0.448504781584731 620 674616 SGTC_2155 5570423 76 µM -0.129739835015301 0.439350591688716 no 1876 0.448386132559666 620 797402 SGTC_34 0469-0683 81.75 µM -0.129788495878676 0.439330388003352 no 1877 0.448366882441916 603 3690923 SGTC_2515 chrysin 20.77 µM -0.129950571712978 0.439263096273259 no 1878 0.448302766517975 618 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_175 3793-3120 23.7 µM -0.130586445976402 0.438999106707597 no 1879 0.448051232723342 636 5322297 SGTC_1129 3453-1384 223 µM -0.130970411164311 0.438839712846497 no 1880 0.447899357109771 674 1084452 SGTC_439 amiodarone 34.4 µM -0.131430021519802 0.438648929767161 no 1881 0.447717570452443 617 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2658 polymyxin b sulfate 77.05 µM -0.132125087952288 0.438360436567079 no 1882 0.447442676275538 602 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3264 9137442 49.47 µM -0.132812015330086 0.438075353727974 no 1883 0.447171025842702 620 17015726 SGTC_1932 st074806 40.9 µM -0.132952231406657 0.438017166372173 no 1884 0.447115579415801 602 17251235 SGTC_1338 1486-1223 76 µM -0.133956751096741 0.437600346557373 no 1885 0.446718386871712 622 3444526 SGTC_1032 k061-1018 98.7 µM -0.134675753010816 0.437302043230219 no 1886 0.446434122401574 639 4005393 SGTC_45 0kpi-0036 14.9 µM -0.135306462984105 0.437040400267824 no 1887 0.446184787674915 595 2795021 SGTC_1484 3473-2379 286 µM -0.138435657351771 0.435742698452432 no 1888 0.444948058906437 604 671917 SGTC_2788 5282734 71.43 µM -0.139434368409473 0.435328669940177 no 1889 0.444553457774395 638 743706 SGTC_942 3253-1115 227 µM -0.140276143999492 0.434979756077649 no 1890 0.444220906136474 617 46497897 SGTC_1662 st014054 52 µM -0.140788595111445 0.434767371155186 no 1891 0.444018476551454 602 2838777 SGTC_77 0828-0286 12.516 µM -0.140914005030981 0.434715397986336 no 1892 0.443968939066737 618 745345 SGTC_2981 9013952 38.96 µM -0.141101353334018 0.434637758024173 no 1893 0.443894937271708 615 2996344 SGTC_1755 st041960 45.185 µM -0.14129730398195 0.434556555817451 no 1894 0.443817539679532 617 2257073 SGTC_1060 3448-7350 82 µM -0.143376778831281 0.433694989468751 no 1895 0.44299631064715 634 570178 SGTC_1652 st011932 78 µM -0.144405974204789 0.433268690324675 no 1896 0.442589949761935 614 1551076 SGTC_969 1313-0238 134 µM -0.146038378667348 0.432592697620543 no 1897 0.441945545699749 610 5212874 SGTC_416 estradiol valerate 100 µM -0.146330949634981 0.432471562257526 no 1898 0.441830067271176 617 13791 A steroid. SGTC_1431 4049-0260 9.09 µM -0.146395088745287 0.432445007106052 no 1899 0.441804752078336 610 3854841 SGTC_1872 amphotericin b 148 nM -0.148056130479589 0.43175740205186 no 1900 0.441149235299703 625 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2438 5259590 200 µM -0.148795271068472 0.431451493648387 no 1901 0.440857591120418 620 1201127 SGTC_2612 dictamnine 15.46 µM -0.149500718370728 0.431159568236356 no 1902 0.440579271280057 626 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_738 1315-0003 72.4 µM -0.149975524532663 0.430963106990348 no 1903 0.440391962713459 645 6251474 SGTC_1514 1189-1591 158 µM -0.152034608717478 0.430111314967601 no 1904 0.439579819560358 663 767698 YMR146C TIF34 SGTC_2991 9074669 71.4286 µM -0.154773691450212 0.428978729006412 no 1905 0.438499866216371 628 17333109 SGTC_2307 7538926 6.34 µM -0.156532460234139 0.428251801559163 no 1906 0.43780666751139 613 96582 SGTC_765 1319-0117 244 µM -0.157626720826535 0.427799648710105 no 1907 0.437375473308518 600 3487746 YGL099W LSG1 SGTC_345 1362-0200 395 µM -0.158209916258097 0.427558708714202 no 1908 0.437145695061009 631 1419823 SGTC_832 4083-0019 164 µM -0.158975402681046 0.427242498457408 no 1909 0.436844126585671 611 1990758 SGTC_2949 9072542 2.23 µM -0.15948832662615 0.427030643879369 no 1910 0.436642077302897 660 16457352 SGTC_1461 k072-0203 53.8 µM -0.160919038723697 0.426439823802019 no 1911 0.436078583495805 620 5418714 SGTC_1983 st071813 46.9 µM -0.1609740948647 0.426417091368553 no 1912 0.436056901917409 633 11838595 SGTC_1500 4488-1866 171 µM -0.161228848921229 0.426311907745958 no 1913 0.435956580097518 643 2900003 SGTC_1341 1486-1360 280 µM -0.161543159753001 0.426182141365793 no 1914 0.435832810574847 621 3976547 SGTC_2908 7930301 100 µM -0.162230826939689 0.42589825895856 no 1915 0.435562042476491 634 2223178 SGTC_869 0564-0080 44.1 µM -0.162888095501693 0.425626961584533 no 1916 0.4353032720291 616 6843321 SGTC_2365 9042475 200 µM -0.163309695422962 0.425452958472545 no 1917 0.435137300270459 618 6464479 SGTC_2306 7482397 179.52 µM -0.164363067999945 0.425018273086254 no 1918 0.434722667799513 655 891448 SGTC_944 3370-0224 231 µM -0.167093487228348 0.42389196218059 no 1919 0.433648245206371 625 4580514 SGTC_1942 st076330 65.2 µM -0.168022920310102 0.423508707924467 no 1920 0.433282623808213 672 24208414 SGTC_1507 4075-3230 155 µM -0.168101187649734 0.423476437472357 no 1921 0.433251837518947 610 659771 SGTC_1742 st038235 28.8875 µM -0.169489572386627 0.422904077264016 no 1922 0.432705786867735 617 564103 YBR002C RER2 SGTC_1884 5633444 25 µM -0.173025870908765 0.421446979434161 no 1923 0.431315546133422 626 5724239 SGTC_383 2324-0395 7.37 µM -0.175205385715046 0.420549465459878 no 1924 0.430459126301344 640 3146421 SGTC_467 ro 31-8220 72.8 µM -0.17623622972508 0.420125112263275 no 1925 0.43005417950329 630 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_425 3825-7017 13.1 µM -0.176299157213351 0.42009921078221 no 1926 0.430029462055057 618 3397440 SGTC_2174 5790901 200 µM -0.176377973639484 0.420066769769439 no 1927 0.429998503937318 626 786020 SGTC_1485 3909-9022 254 µM -0.176444330193832 0.420039457688126 no 1928 0.429972440236848 627 714516 SGTC_2444 5485484 36.41 µM -0.177197642493373 0.419729424514599 no 1929 0.429676573690558 655 6790631 SGTC_1616 st002734 56.1 µM -0.177231966197694 0.419715299437673 no 1930 0.429663093852029 620 4026101 SGTC_863 0466-0191 129 µM -0.177414784925068 0.419640066626736 no 1931 0.429591297420347 641 765160 YPR165W RHO1 SGTC_577 r071-0003 38.6 µM -0.177772175371433 0.419493003265343 no 1932 0.42945095004372 612 4568517 YMR134W ERG29 SGTC_2999 9069765 71.4286 µM -0.177810672445658 0.419477162692177 no 1933 0.429435832758348 628 2097066 SGTC_3075 9116269 49.47 µM -0.178152377857223 0.419336565273228 no 1934 0.429301654158578 644 17015205 YNL244C SUI1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.178485410968356 0.419199546051085 no 1935 0.429170888799364 622 688669 SGTC_2188 6126565 140.678 µM -0.179165814789794 0.418919639190426 no 1936 0.42890375260351 648 874518 SGTC_1412 3909-8563 178 µM -0.17975291599664 0.418678148456687 no 1937 0.428673274505221 638 23767530 SGTC_2640 pentamidine 10.38 µM -0.18051999101682 0.418362675772462 no 1938 0.428372180815273 644 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_960 1222-0186 7.7 µM -0.180734393859036 0.418274508327443 no 1939 0.428288030467001 646 3126296 SGTC_1774 st048371 48.465 µM -0.181490703421508 0.417963529030226 no 1940 0.427991214789211 619 4242727 SGTC_1769 st044406 64.4 µM -0.181506939552658 0.417956853620916 no 1941 0.427984843322905 640 670903 SGTC_221 trifluoperazine 10.304 µM -0.18155176366751 0.417938424518658 no 1942 0.427967253310104 629 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2361 9034121 116 µM -0.183041984568801 0.417325834071126 no 1943 0.427382538077973 641 6496917 SGTC_1939 st074455 53.6 µM -0.183245736353989 0.417242092651647 no 1944 0.427302604729602 626 1644229 SGTC_1366 1683-0113 21.9 µM -0.184729581787051 0.416632349736378 no 1945 0.426720571284728 636 708623 SGTC_2133 5320837 200 µM -0.185089083804564 0.416484653009952 no 1946 0.426579581770553 656 2841355 SGTC_2806 7952793 58.44 µM -0.185434771362575 0.416342642893543 no 1947 0.426444018858706 626 2972490 SGTC_1996 st072960 66.8 µM -0.186858425735221 0.415757914091884 no 1948 0.425885818226395 620 1719405 SGTC_2451 5856223 45.7 µM -0.186887803055923 0.415745850084847 no 1949 0.425874301232688 608 2179896 SGTC_1416 3966-0321 25.3 µM -0.18704577253583 0.415680980148906 no 1950 0.425812372452065 641 582530 YLR208W SEC13 SGTC_400 oxethazaine 37.5 µM -0.187112103173433 0.415653742254424 no 1951 0.425786369395321 646 4621 A local anesthetic. SGTC_1839 st053978 48 µM -0.187271698536453 0.415588207960534 no 1952 0.425723805854544 617 3788398 SGTC_124 0136-0217 7.121 µM -0.187538205614043 0.415478777978322 no 1953 0.425619335644781 641 3976905 SGTC_1520 flindersine 88 µM -0.187806191440784 0.415368747419363 no 1954 0.425514291033352 654 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3287 9117173 37.0625 µM -0.18958107104457 0.414640179060359 no 1955 0.424818710659255 625 2789709 SGTC_18 0111-0177 500 nM -0.190654342359343 0.41419975536899 no 1956 0.424398205976182 653 721752 SGTC_1600 coumarin 106 71.1 µM -0.190963787622367 0.414072792552814 no 1957 0.424276982150766 675 100336 A hepatotoxic, DNA x-linker. SGTC_2198 6589944 200 µM -0.192480600973572 0.413450586785592 no 1958 0.423682880990559 636 5290268 SGTC_877 0771-0151 33.1 µM -0.192636515489399 0.413386642021983 no 1959 0.423621822641542 654 6166523 SGTC_614 0462-0418 107 µM -0.19265104496776 0.413380683206579 no 1960 0.423616132783894 629 5188303 SGTC_53 0973-0023 39.979 µM -0.193292802849488 0.413117506015461 no 1961 0.423364831269729 660 674768 SGTC_247 mechlorethamine 29.705 µM -0.193536171068126 0.413017713837954 no 1962 0.423269540544699 628 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_578 3460-0051 92 µM -0.194181033122053 0.412753317890732 no 1963 0.423017066791558 656 2876744 SGTC_2417 cerulenin 830 nM -0.194653974065461 0.412559435416249 no 1964 0.422831922976772 659 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2980 9014342 25.29 µM -0.195369563370477 0.412266119647142 no 1965 0.422551821191106 652 2996599 SGTC_1554 st069299 38.7 µM -0.196465633758937 0.411816942015918 no 1966 0.422122864373998 625 24207999 SGTC_179 1273-0063 6.77 µM -0.196796600119386 0.411681332271583 no 1967 0.421993355901398 672 3108139 SGTC_1912 st060209 90.8 µM -0.1969411257789 0.411622117815844 no 1968 0.421936805072647 664 688787 SGTC_1242 0402-0103 60.1 µM -0.19794258603187 0.411211859027551 no 1969 0.421544992243059 628 432868 SGTC_401 neomycin 50 µM -0.199558551769902 0.410550066457197 no 1970 0.420912923281167 633 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3144 9087057 49.47 µM -0.199654012072489 0.410510980183736 no 1971 0.420875591290643 710 17249618 SGTC_1788 fluconazole 20 µM -0.200175157909953 0.41029761241402 no 1972 0.420671797539985 630 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1923 st058458 19.1 µM -0.200700721132922 0.410082462965009 no 1973 0.42046629790347 686 3534982 SGTC_1185 1319-0113 81.3 µM -0.200826677056105 0.410030904494847 no 1974 0.420417051296833 660 4672763 SGTC_1487 3970-0795 2.82 µM -0.200906887293174 0.409998072255467 no 1975 0.420385691118396 636 3765103 SGTC_3003 9075612 71.4286 µM -0.202240078193521 0.40945245339946 no 1976 0.419864521275713 665 6501993 SGTC_2707 st078556 66.6 µM -0.202840551750449 0.409206762084143 no 1977 0.419629830507363 625 17250899 SGTC_2524 avocatin b 10.57 µM -0.20292452667584 0.409172405526416 no 1978 0.41959701178845 629 6710748 SGTC_902 1120-0002 2.07 µM -0.203570430583856 0.40890817099709 no 1979 0.419344601113169 654 3280475 SGTC_646 4092-0839 27.3 µM -0.204321872456132 0.408600813762106 no 1980 0.419050989372336 647 877796 SGTC_682 0kpi-0099 17 µM -0.204585081111084 0.408493168571633 no 1981 0.41894815620562 654 1714895 YML126C ERG13 SGTC_1726 st035556 14.5795 µM -0.205426392283701 0.408149141493196 no 1982 0.418619500946374 659 5919439 SGTC_943 3253-1379 105 µM -0.205442905095758 0.408142389818625 no 1983 0.418613050841842 657 668464 SGTC_2893 9048488 25.97 µM -0.205457556392514 0.408136399293791 no 1984 0.418607327886069 620 6467338 SGTC_2085 5307070 144.047 µM -0.20545761825108 0.408136374001518 no 1985 0.418607303723477 662 2840351 SGTC_1384 3089-0840 101 µM -0.206983506976994 0.407512596590599 no 1986 0.418011369555785 639 1069836 SGTC_2123 5259487 200 µM -0.207068556557875 0.4074778355338 no 1987 0.417978159059853 632 2173474 SGTC_999 SEC7.066 22.7 µM -0.207763350035267 0.407193890185243 no 1988 0.41770687528701 632 740511 YDR170C SEC7 SGTC_1359 1582-0056 520 nM -0.209333729286194 0.406552293919404 no 1989 0.417093861423154 655 3661189 SGTC_2186 6124449 200 µM -0.211267436593547 0.405762600534396 no 1990 0.416339295630842 642 3834182 YLR033W RSC58 SGTC_2229 7354935 190 µM -0.211415904343698 0.405701984620154 no 1991 0.416281373671319 651 318112 SGTC_2954 9074818 52.69 µM -0.211596649911902 0.405628193478761 no 1992 0.416210861569319 672 16648742 SGTC_226 1,3-diallylurea 8.28947 mM -0.212066383527855 0.40543643583697 no 1993 0.416027622640771 639 74537 YKL182W FAS1 SGTC_1272 0839-0021 27 µM -0.212701084260677 0.405177370327948 no 1994 0.415780060499469 664 5027250 SGTC_2426 5582046 32.21 µM -0.213219434128105 0.404965826511496 no 1995 0.4155779052722 660 2251934 SGTC_1574 spiramycin 23.7 µM -0.214320617171123 0.404516514815944 no 1996 0.415148520689225 632 6419898 An antibiotic and protein synthesis inhibitor. SGTC_342 k048-0088 23.3 µM -0.215026499084577 0.404228562572248 no 1997 0.414873329238246 629 6820570 SGTC_1893 st059353 36.1 µM -0.216158823210126 0.403766759066092 no 1998 0.414431974535907 704 3112488 SGTC_1316 1272-0050 65.9 µM -0.217718790609151 0.403130766647733 no 1999 0.413824111036526 648 7340392 SGTC_1689 st020265 53.493 µM -0.218546527669896 0.402793405500234 no 2000 0.413501655242008 674 5758320 YPR016C TIF6 SGTC_470 aa-861 153 µM -0.219034195758889 0.402594680267125 no 2001 0.413311705052916 637 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2464 5717415 7.67 µM -0.21957977984667 0.402372384035144 no 2002 0.413099220218361 637 5285744 SGTC_875 0709-0210 25.7 µM -0.220927017791185 0.401823592246325 no 2003 0.412574629998851 648 6251364 SGTC_3038 9091290 49.47 µM -0.221046599336215 0.40177489053558 no 2004 0.412528074626598 657 25236843 SGTC_2904 7225135 42.03 µM -0.22150122411975 0.401589750437163 no 2005 0.412351091780396 650 4446116 SGTC_2031 5180455 200 µM -0.222153660424029 0.40132409274314 no 2006 0.412097133180975 639 29949 SGTC_2732 terfenadine 20 µM -0.223646127720809 0.400716564606922 no 2007 0.411516333955171 642 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1773 st048542 73.5835 µM -0.223978130324444 0.400581451239094 no 2008 0.4113871602127 647 3237138 SGTC_1212 0520-0165 585 µM -0.224324381964501 0.40044055168677 no 2009 0.411252452766287 729 5403258 SGTC_1441 4106-0040 13 µM -0.224342278815994 0.40043326930539 no 2010 0.411245490371119 631 2904180 SGTC_2358 9037157 4 µM -0.225853197750273 0.399818588569173 no 2011 0.410657800022577 636 2388925 SGTC_801 0866-0028 10.1 µM -0.226234733529734 0.399663409174154 no 2012 0.410509428686875 633 6849771 SGTC_2933 9026794 32.47 µM -0.226781081964268 0.399441224273804 no 2013 0.410296987438998 670 17586027 SGTC_2618 avocadyne 43.43 µM -0.226906038359971 0.399390412513312 no 2014 0.410248403290853 641 3015189 SGTC_1154 4088-0362 150 µM -0.227325771131796 0.399219746567759 no 2015 0.410085217578154 649 6618304 SGTC_3020 9089140 49.47 µM -0.227341648445989 0.3992132911313 no 2016 0.410079045025522 627 17217859 SGTC_2195 6536160 144.242 µM -0.227723930885332 0.39905787014536 no 2017 0.40993043351616 634 3834386 SGTC_2014 4013930 200 µM -0.229313091837679 0.398411951662326 no 2018 0.409312789376971 679 64556 SGTC_1949 st076024 69.1 µM -0.231770663485422 0.397413613844047 no 2019 0.408358071904694 632 2921930 SGTC_1634 st006576 41 µM -0.231903156670289 0.397359810242094 no 2020 0.408306616345914 651 3915356 SGTC_111 0083-0039 52.457 µM -0.232183805672063 0.397245849116349 no 2021 0.408197627651088 633 759313 SGTC_2368 9071271 200 µM -0.232873801071346 0.396965704949637 no 2022 0.407929701454775 669 27209959 SGTC_2955 9076254 12.21 µM -0.232918516726312 0.396947551835285 no 2023 0.407912339786219 641 16459619 SGTC_2246 7293507 91.5585 µM -0.232928676606044 0.396943427282783 no 2024 0.407908395052828 649 887656 SGTC_2728 chlorpromazine 9.18 µM -0.23303827002027 0.396898936958462 no 2025 0.407865844276479 640 2726 A thorazine and dopamine antagonist. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.233432846542597 0.396738766575658 no 2026 0.407712654864538 681 7104 SGTC_1054 3429-0080 167 µM -0.233805441566394 0.396587535130122 no 2027 0.407568012446835 689 1162877 SGTC_1619 st003326 88.7 µM -0.234500485078756 0.396305467650735 no 2028 0.407298228324043 621 2849032 SGTC_3132 9126706 49.47 µM -0.234956352973703 0.396120493574879 no 2029 0.407121305112254 665 850858 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.235311529460539 0.395976392497593 no 2030 0.406983473562082 640 3256 An antibiotic and ribosome inhibitor. SGTC_615 k087-0205 167 µM -0.235479672683338 0.395908178918988 no 2031 0.406918227084974 637 9642773 SGTC_82 0054-0107 293.755 µM -0.235543215312229 0.395882401308037 no 2032 0.40689357060739 645 3104697 SGTC_1785 bathophenanthroline 24 µM -0.236146417047962 0.395637720564289 no 2033 0.406659528333182 647 72812 An iron chelator. SGTC_1188 1403-0014 4.57 µM -0.236498339973343 0.395494986710488 no 2034 0.406522997630383 643 9614867 SGTC_1465 k213-0056 144 µM -0.236886064465052 0.395337748589053 no 2035 0.40637259064195 642 24048857 YMR208W ERG12 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.237666716143976 0.395021214152048 no 2036 0.406069800351007 626 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1770 st043884 66.3 µM -0.237872496219096 0.394937787083708 no 2037 0.405989994064924 648 670149 SGTC_1118 chelidonine 707.474 nM -0.238986930087019 0.394486058645074 no 2038 0.405557858707254 638 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1578 josamycin 24.2 µM -0.23902067058643 0.394472384364943 no 2039 0.405544777208315 689 5282165 A P450 substrate. SGTC_2386 9075165 157.42 µM -0.239192725432141 0.394402656353952 no 2040 0.405478071618448 649 16452277 SGTC_814 3342-0569 96 µM -0.240532123104317 0.393859959628175 no 2041 0.404958881725521 648 4346283 SGTC_965 1291-5240 308 µM -0.240766234779189 0.393765123460757 no 2042 0.404868150307187 680 2834598 SGTC_1407 3909-7909 12.3 µM -0.241640366657518 0.393411077591327 no 2043 0.404529420359479 648 4411780 SGTC_1172 0370-0043 85 µM -0.242487157544786 0.393068189547546 no 2044 0.404201353383029 665 376585 SGTC_845 0330-0138 4.51 µM -0.243093628461232 0.39282266438007 no 2045 0.403966433475026 668 9039800 SGTC_1395 3486-0190 4.35 µM -0.243594138475813 0.392620068792722 no 2046 0.403772584196582 679 6748079 SGTC_2481 5478948 45.16 µM -0.244658971266947 0.392189144447571 no 2047 0.403360249414541 649 77792 SGTC_3031 9088762 49.47 µM -0.245447718146594 0.391870033761519 no 2048 0.403054892492282 656 205253 SGTC_3300 9124615 50.48 µM -0.246034596131267 0.391632642235114 no 2049 0.40282772581009 669 24824903 SGTC_1676 st018489 23.4 µM -0.246363926348985 0.391499446176837 no 2050 0.402700264180732 646 3696235 SGTC_2856 9022925 19.48 µM -0.246475440190025 0.391454347810103 no 2051 0.40265710699839 657 4944862 SGTC_500 h-89 112 µM -0.249089179185268 0.390397720005067 no 2052 0.401645899737814 693 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2048 5246248 200 µM -0.249415317551337 0.390265932212736 no 2053 0.401519768889336 637 677046 SGTC_367 0335-0881 7.1 µM -0.249549283888274 0.390211802007944 no 2054 0.40146796168039 692 23828853 SGTC_2401 5128683 200 µM -0.250555547910986 0.389805280826311 no 2055 0.40107887658024 708 708373 SGTC_1481 3346-2004 36 µM -0.250923255475234 0.389656760477589 no 2056 0.400936722108199 670 2770522 SGTC_1314 1222-0010 41.1 µM -0.251227273879681 0.389533976912659 no 2057 0.40081919954887 657 3526027 SGTC_2561 acetosyringone 100 µM -0.251654154669697 0.389361591669114 no 2058 0.400654197970911 656 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_277 nystatin 15.5 µM -0.251678023396188 0.389351953516933 no 2059 0.400644972551591 680 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2382 9035899 200 µM -0.251702212892983 0.389342185907681 no 2060 0.400635623208986 694 6462679 SGTC_2624 nerol 100 µM -0.253071041040602 0.388789573395742 no 2061 0.400106658257677 658 637566 A natural product oil. SGTC_3207 9114163 49.47 µM -0.254169931032169 0.388346100911988 no 2062 0.399682139753648 720 849233 SGTC_459 nigericin 15.3 µM -0.25422048366526 0.388325703184051 no 2063 0.399662613324323 711 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_134 0269-0018 6.916 µM -0.254621405143145 0.388163944337956 no 2064 0.399507762528698 642 4378915 SGTC_220 paclitaxel 373.376 µM -0.254826724566826 0.38808111210236 no 2065 0.399428466644843 666 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3339 9145883 14.936 µM -0.256181929125486 0.387534508345418 no 2066 0.398905180805626 681 2030670 SGTC_2380 9035439 200 µM -0.256310359376017 0.387482719253155 no 2067 0.398855599374931 654 6462575 SGTC_3352 9151559 45.5865 µM -0.256493105350435 0.38740903096854 no 2068 0.398785051778275 644 17159339 SGTC_2370 9071495 200 µM -0.257020160605478 0.387196530286254 no 2069 0.398581604913706 688 21791103 SGTC_730 1436-0052 41.2 µM -0.257781332373595 0.386889697047913 no 2070 0.398287836156368 634 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.258413662576692 0.386634854409943 no 2071 0.398043836693701 717 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1733 st037357 54.9 µM -0.259035320364235 0.386384360631942 no 2072 0.397803994296079 698 1272339 YGL099W LSG1 SGTC_334 1502-1024 68.5 µM -0.260184548806362 0.385921409723576 no 2073 0.39736071110084 687 3296216 SGTC_3254 9136651 49.47 µM -0.260381073992844 0.385842258492902 no 2074 0.397284920181115 671 16454030 SGTC_1352 1496-0991 99 µM -0.26158542508911 0.385357305644427 no 2075 0.396820540974654 690 3000039 SGTC_132 0417-1715 25.805 µM -0.261892738795252 0.38523358912058 no 2076 0.396702068949319 685 6769098 SGTC_774 k060-0086 136 µM -0.262123736001354 0.385140603327671 no 2077 0.396613023854733 716 5911235 SGTC_2689 tacrolimus 100 µM -0.262947456456738 0.384809076059235 no 2078 0.396295538976368 669 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1106 tegaserod maleate 11.7 µM -0.265925968774027 0.383611002311015 no 2079 0.395148112384147 675 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2473 5854593 8.94 µM -0.26631385863692 0.383455059475217 no 2080 0.394998750368027 660 2872951 SGTC_1929 genistein trimethyl ether 50.5 µM -0.266667187409626 0.383313027616843 no 2081 0.39486270997442 649 136420 SGTC_1550 gossypolone 36.6 µM -0.267647868603005 0.382918893507256 no 2082 0.394485190451883 661 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1339 1486-1321 22.7 µM -0.267791312415439 0.382861253832572 no 2083 0.394429979133029 673 3469382 SGTC_2880 9042983 58.44 µM -0.268019082716557 0.382769734782306 no 2084 0.394342315026741 692 6464714 SGTC_3105 9121040 49.47 µM -0.268227998348742 0.382685797370886 no 2085 0.394261912400099 652 41448907 SGTC_763 3453-1109 128 µM -0.271748878916581 0.381272021847534 no 2086 0.392907557531707 684 1560353 SGTC_539 4859-0462 2.54 µM -0.272402092689995 0.381009903704585 no 2087 0.392656431894064 653 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1865 st057639 52.2 µM -0.273794292378324 0.380451431530024 no 2088 0.39212135505257 655 688818 SGTC_120 rhodamine 6G 52.259 µM -0.273985206593901 0.380374866883893 no 2089 0.392047995123432 675 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_31 0508-1974 57.237 µM -0.274078578784608 0.380337422406753 no 2090 0.392012117697836 647 6810525 SGTC_1674 st016616 23.6 µM -0.274706816365289 0.380085513310981 no 2091 0.391770746935689 640 625830 SGTC_2147 5545932 89.7195 µM -0.275309116802433 0.379844052178299 no 2092 0.391539380409198 708 797404 SGTC_2263 7948595 193.29 µM -0.2753446531983 0.379829807165201 no 2093 0.391525730724437 671 2971371 SGTC_2408 sulbentine 18.36 µM -0.276519265413124 0.379359047515081 no 2094 0.391074632308537 645 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2384 9036245 200 µM -0.277505963182583 0.378963738146401 no 2095 0.390695813801794 669 6462766 SGTC_746 1095-0025 46.6 µM -0.278276249504007 0.378655219537068 no 2096 0.390400153252826 687 6749286 SGTC_1155 4088-0394 48.2 µM -0.279726708947409 0.378074484876135 no 2097 0.389843592621473 672 2326248 SGTC_1263 0774-1208 64.8 µM -0.279860857068209 0.378020788570978 no 2098 0.389792129587955 687 906585 SGTC_702 1488-0190 94 µM -0.280159044256819 0.377901439766352 no 2099 0.389677743425262 655 949357 SGTC_1434 4073-0095 163 µM -0.280202597433763 0.377884008672563 no 2100 0.389661036998683 677 24133745 SGTC_2019 4016004 108 µM -0.280641851842864 0.377708221743769 no 2101 0.389492556179231 671 45595336 SGTC_742 0kpi-0133 140 µM -0.280976879748708 0.37757416264625 no 2102 0.389364066531086 686 2728852 SGTC_2259 7964009 200 µM -0.282193755207892 0.377087362524711 no 2103 0.388897473222845 670 313134 SGTC_788 1182-0090 188 µM -0.28314158430081 0.376708327240292 no 2104 0.388534152807851 656 5715185 SGTC_394 menadione 8.33 µM -0.283296457898102 0.376646404829169 no 2105 0.388474796153112 689 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1526 st051518 75 µM -0.283423280266591 0.376595700377612 no 2106 0.388426192315424 668 673993 SGTC_1777 st045864 34.765 µM -0.28343095097871 0.376592633642637 no 2107 0.388423252621532 660 4691462 SGTC_743 1275-0778 158 µM -0.284475655559238 0.376175035733376 no 2108 0.388022943876425 678 2849257 YMR203W TOM40 SGTC_99 0109-0120 622.8 µM -0.285397213886185 0.375806783147173 no 2109 0.387669920908723 700 759414 SGTC_1020 4335-0961 93.3 µM -0.286062210046998 0.375541122435128 no 2110 0.387415237310579 704 669075 SGTC_3 0833-0587 95.581 µM -0.286079377374514 0.37553426500414 no 2111 0.387408663121531 672 5382644 SGTC_2528 xanthyletin 44.79 µM -0.28780405369662 0.37484554962337 no 2112 0.386748367100286 664 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2743 auranofin 4.32 µM -0.287979574304226 0.374775481270121 no 2113 0.386681187000093 654 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2964 9083345 53.42 µM -0.28907678744355 0.374337564265999 no 2114 0.386261308283506 651 17741579 SGTC_2625 euphol 100 µM -0.292527408818974 0.372961419458812 no 2115 0.384941703340582 661 6708538 A triterpene alcohol. SGTC_3087 9117406 49.47 µM -0.293526357332863 0.372563329574699 no 2116 0.384559928011677 662 42546093 SGTC_691 1548-0686 185 µM -0.29355767511437 0.372550851357807 no 2117 0.384547960877849 652 46495133 SGTC_3061 glucosamine 200 µM -0.294710434845069 0.372091640426053 no 2118 0.384107545594575 663 91431 and experimental redox chemotherapeutic SGTC_2336 9001819 198.65 µM -0.295244161016588 0.371879087947572 no 2119 0.38390368455711 695 2989602 SGTC_3236 9132701 49.47 µM -0.295589859531486 0.371741436914769 no 2120 0.383771659344593 697 24282524 SGTC_548 1436-0017 110 µM -0.296414192408199 0.371413268337553 no 2121 0.383456894049489 689 9677137 SGTC_2116 5511452 16.8835 µM -0.300690814071408 0.369712241537018 no 2122 0.381825137061648 700 870744 SGTC_565 1418-0001 44.5 µM -0.300718777118313 0.369701127575687 no 2123 0.381814474553629 708 2862145 SGTC_617 3770-0098 35 µM -0.300951050273306 0.369608814416789 no 2124 0.381725910619264 699 5962639 SGTC_881 0833-0569 170 µM -0.301313981608545 0.369464588352801 no 2125 0.381587540139632 658 5418700 SGTC_786 4544-0069 423 µM -0.301349747767394 0.369450376155902 no 2126 0.381573904823747 663 748821 YLR208W SEC13 SGTC_759 3486-0358 89.3 µM -0.302329059664865 0.369061301884132 no 2127 0.381200613890592 692 875103 SGTC_375 3970-0961 9.27 µM -0.302340076220164 0.369056925840218 no 2128 0.381196415263707 667 2898222 SGTC_1252 0493-0875 34.8 µM -0.304294240108323 0.368280953382234 no 2129 0.380451866480067 670 3960963 SGTC_2021 4019055 173 µM -0.304375939526688 0.368248523304277 no 2130 0.380420748106777 709 44827708 YER133W GLC7 SGTC_1622 st003707 19.4 µM -0.304766429253612 0.368093533795891 no 2131 0.380272025730826 694 10140899 SGTC_2068 5226020 147 µM -0.305405781802071 0.367839814358955 no 2132 0.380028559388917 705 1810509 SGTC_2053 5265679 138 µM -0.307124295793398 0.3671581286004 no 2133 0.379374382716597 663 764595 SGTC_842 0271-0008 11.1 µM -0.30727780410546 0.367097256539244 no 2134 0.379315964373236 695 1221709 SGTC_1817 st052116 64.4 µM -0.308306803906475 0.366689304116451 no 2135 0.378924444640089 682 4361398 SGTC_1191 1487-1166 10.6 µM -0.308477363312891 0.366621699468327 no 2136 0.378859561209271 714 3955771 SGTC_543 3844-1095 191 µM -0.309305119753303 0.366293660373241 no 2137 0.378544718399258 697 4230703 SGTC_634 1611-4317 11.2 µM -0.310053384673204 0.365997207743371 no 2138 0.378260180086258 685 2843522 SGTC_1201 1889-3372 45.9 µM -0.310782342679939 0.365708481165688 no 2139 0.377983046971856 678 5392199 SGTC_1423 4048-0112 5.59 µM -0.311097471056663 0.365583688270724 no 2140 0.37786326181829 682 X1423 SGTC_260 nsc-65238 3.989 µM -0.311241293915739 0.365526738206465 no 2141 0.377808596434549 677 3246252 SGTC_883 0850-0245 24.6 µM -0.312026641507973 0.365215813561135 no 2142 0.377510138204231 664 6823229 YPR165W RHO1 SGTC_3127 9126946 49.47 µM -0.312277493895123 0.365116517989142 no 2143 0.37741482134758 702 27243249 SGTC_236 1509-0011 5.31 µM -0.312862195861438 0.364885108959069 no 2144 0.377192680027096 712 3107280 SGTC_1961 st076550 68.7 µM -0.31421326172226 0.364350582428328 no 2145 0.37667953550192 685 1579337 SGTC_2046 4110841 106 µM -0.314424318158262 0.364267105280846 no 2146 0.376599394397906 718 44119630 YMR134W ERG29 SGTC_2154 5570129 200 µM -0.315257630439043 0.363937576118086 no 2147 0.3762830259591 714 673366 SGTC_496 calpeptin 138 µM -0.315503639636841 0.363840312235927 no 2148 0.376189644023578 670 73364 A calpain inhibitor. SGTC_2814 7977482 42.97 µM -0.315704629276491 0.363760854105915 no 2149 0.376113356314148 690 6456762 SGTC_390 dec-rvkr-cmk 16.7 µM -0.317218989855192 0.363162363776847 no 2150 0.37553872082323 674 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_667 1498-1044 59 µM -0.318093269396348 0.362816991784165 no 2151 0.375207094469197 693 6739982 SGTC_2532 xanthone 78.9 µM -0.319130366309325 0.36240744572548 no 2152 0.374813828818184 706 7020 An insecticide. SGTC_2070 5230947 200 µM -0.319280186257953 0.362348295336977 no 2153 0.374757028058953 721 2835538 SGTC_1936 st074407 74.3 µM -0.320624220681188 0.361817804461437 no 2154 0.374247590227611 671 809813 SGTC_819 1013-0258 27.7 µM -0.321188586059524 0.361595128305958 no 2155 0.374033740647606 711 5753198 SGTC_2248 tofa 1.1 µM -0.321275665117697 0.361560774540877 no 2156 0.37400074806232 685 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2859 9028643 45.46 µM -0.321321997857666 0.361542496156938 no 2157 0.37398319385183 669 17151580 SGTC_1743 st037606 46.3785 µM -0.323541947847423 0.360667091175348 no 2158 0.373142422251761 665 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1295 1013-0063 9.78 µM -0.323908881020374 0.360522466562617 no 2159 0.373003510044489 687 6826038 SGTC_1909 st060837 51.5 µM -0.324757525194222 0.360188054771117 no 2160 0.372682296736597 722 678937 SGTC_355 1311-2252 105 µM -0.327544240048298 0.359090691542864 no 2161 0.37162814393893 683 5338538 SGTC_2199 6590217 200 µM -0.328303310326904 0.358791982866327 no 2162 0.371341170744846 668 703109 SGTC_2471 5466956 24.79 µM -0.328583120408615 0.358681894016286 no 2163 0.371235404112603 688 724419 SGTC_849 0386-0493 241 µM -0.328858845085039 0.35857342401776 no 2164 0.371131191252378 689 726119 SGTC_704 1310-0270 142 µM -0.329581946606839 0.358289010322012 no 2165 0.370857932804581 726 5718033 SGTC_2520 obtusaquinone 4.71 µM -0.3325295798083 0.357130448142474 no 2166 0.369744703885109 661 5967872 SGTC_1971 st069429 63.5 µM -0.332865838546167 0.356998365654284 no 2167 0.369617778614032 706 1246522 YGL099W LSG1 SGTC_2703 st077852 53.4 µM -0.332886720562871 0.356990163759686 no 2168 0.369609896891291 720 6281836 SGTC_2512 diallyl trisulfide 49.23 µM -0.33294578520088 0.356966965116142 no 2169 0.369587603790375 703 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_209 4077-0173 175.592 µM -0.33320023402729 0.356867032049331 no 2170 0.369491570741601 675 15993494 SGTC_3060 1327-0027 12.5 µM -0.334695860198427 0.356279833651905 no 2171 0.368927262304333 681 16000455 YPR107C YTH1 SGTC_711 k292-0785 179 µM -0.335197427054112 0.356082989483254 no 2172 0.368738081396718 695 4146315 SGTC_450 aminopyrene 156 nM -0.335460381994868 0.355979805905923 no 2173 0.368638912798227 711 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1488 4013-0813 75.9 µM -0.337448736462627 0.355199917080207 no 2174 0.367889325219297 683 2910057 SGTC_2863 9028737 58.44 µM -0.340525115230015 0.353994469646003 no 2175 0.366730556224527 707 6460917 SGTC_3094 9117742 49.47 µM -0.341905612514563 0.353454010426923 no 2176 0.366210962868128 704 17149698 SGTC_2403 6032726 181.2 µM -0.342538181859031 0.353206460636156 no 2177 0.365972957461882 696 2881040 SGTC_2751 anetholtrithion 17.25 µM -0.345812695550135 0.351926006756997 no 2178 0.364741741739482 710 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1048 3161-0300 24.5 µM -0.345913037635641 0.351886795770861 no 2179 0.364704035103172 668 2165101 SGTC_2565 isoliquiritigenin 100 µM -0.347002528005063 0.351461153740421 no 2180 0.364294709784304 661 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1680 diphenhydramine 100 µM -0.348355933976341 0.350932664522644 no 2181 0.36378644598045 724 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1479 0549-0158 134 µM -0.34842041788065 0.350907491497548 no 2182 0.363762235394992 700 5440202 SGTC_92 0063-0024 660.874 µM -0.350579036482511 0.350065194934601 no 2183 0.362952093001524 702 3594437 SGTC_2342 7990637 118.86 µM -0.351049760942463 0.349881615223322 no 2184 0.36277550859259 739 2033102 YER133W GLC7 SGTC_2671 danthron 100 µM -0.352762914058998 0.349213792290968 no 2185 0.36213309443318 697 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2054 5233173 129 µM -0.353057519274336 0.349098995977941 no 2186 0.362022659681932 676 6889 SGTC_2279 7948423 32.93 µM -0.353751560183841 0.348828609543519 no 2187 0.361762539185607 679 1247112 SGTC_1296 1068-0102 11.9 µM -0.354746653931278 0.348441072027189 no 2188 0.361389698143948 711 767053 SGTC_641 4092-0595 30 µM -0.355308762312339 0.348222229774032 no 2189 0.361179145902825 693 786260 SGTC_2803 7707263 71.43 µM -0.355586880633032 0.348113970331433 no 2190 0.361074985033526 694 2199229 SGTC_3194 9111903 49.47 µM -0.355624607070647 0.348099286012847 no 2191 0.361060856521913 735 17087251 SGTC_2296 7971656 126.45 µM -0.355996000550999 0.34795474012495 no 2192 0.360921780170907 682 666570 SGTC_2586 curcumin 80 µM -0.356907232793859 0.347600183283437 no 2193 0.360580627410181 705 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2925 9010536 32.5 µM -0.358224626613502 0.347087826257978 no 2194 0.360087609554626 703 2994177 SGTC_1053 3366-3204 134 µM -0.358587912510818 0.346946587255153 no 2195 0.35995169532053 699 3632071 YPR165W RHO1 SGTC_1019 4262-0212 3.4 µM -0.358737993308327 0.346888244753905 no 2196 0.359895551551316 708 4677213 SGTC_1856 st057054 55.7 µM -0.35881227634854 0.346859369262189 no 2197 0.359867764105409 730 1266018 SGTC_2705 st078069 42.8 µM -0.360216619087297 0.346313637109759 no 2198 0.359342573766651 720 1530061 SGTC_1534 6-azauridine 81.6 µM -0.36068730765131 0.346130797306758 no 2199 0.359166606973453 691 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_719 2810-4230 27.3 µM -0.362543903901921 0.345409949279026 no 2200 0.358472810580011 689 721079 SGTC_2280 7785178 200 µM -0.363651666695176 0.344980112462498 no 2201 0.358059069991166 683 2954328 SGTC_1503 4585-0012 61.3 µM -0.364969890224158 0.344468872741015 no 2202 0.357566941161989 715 2922052 SGTC_3068 9116768 49.47 µM -0.365719009853834 0.344178472089652 no 2203 0.357287379788146 722 41904888 SGTC_350 k064-0020 19.8 µM -0.366079979725711 0.344038572771809 no 2204 0.357152698017752 711 2790705 SGTC_402 epigallocatechin gallate 10 µM -0.36645866173719 0.34389183178949 no 2205 0.357011426783879 714 65064 An antioxidant. SGTC_3214 9129694 49.47 µM -0.368704338143787 0.343022105871484 no 2206 0.35617405743097 735 17158655 SGTC_803 4488-1585 147 µM -0.370723387492061 0.342240859373009 no 2207 0.355421784491193 719 747204 SGTC_3321 9137793 26.8275 µM -0.371109521646198 0.342091526230201 no 2208 0.355277979692985 683 4904192 SGTC_1706 st031321 9.9705 µM -0.372899591998582 0.341399559107763 no 2209 0.354611587845122 700 6103185 SGTC_3082 9117008 49.47 µM -0.374176124271554 0.34090642986454 no 2210 0.354136643009672 687 41448529 SGTC_1224 0823-0416 294 µM -0.37421964459099 0.340889622585309 no 2211 0.354120454893865 718 3598164 SGTC_1028 k015-0029 4.8 µM -0.374234315467408 0.340883956854396 no 2212 0.354114997873703 696 4588309 SGTC_914 3820-6779 408 µM -0.375165641099239 0.34052436265044 no 2213 0.353768640753995 696 2893481 SGTC_2519 cryptotanshinone 88.04 µM -0.377157278981535 0.339755857875204 no 2214 0.353028363163226 715 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3069 9117009 49.47 µM -0.37747291699958 0.33963412500683 no 2215 0.352911093726397 694 41904981 SGTC_1751 st044839 27.194 µM -0.377834297061975 0.33949477123364 no 2216 0.35277684683905 700 5291326 SGTC_1867 st057372 64 µM -0.378307371624679 0.339312379489669 no 2217 0.352601134943821 704 688837 SGTC_2226 7298446 200 µM -0.378914872128152 0.339078215644057 no 2218 0.352375539964003 729 3283010 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.378969416276908 0.339057194391976 no 2219 0.352355287563396 757 65057 A dermal irritant. YDR527W RBA50 SGTC_1525 8-methoxypsoralen 92.5 µM -0.380044062730948 0.338643129146792 no 2220 0.35195635365923 766 4114 Related to psoralen; DNA damaging agent. SGTC_2792 7535235 81.82 µM -0.381229768323666 0.338186498623701 no 2221 0.351516381038557 697 1281891 SGTC_426 0988-0037 14.6 µM -0.382285683337725 0.337780052374924 no 2222 0.351124736386659 746 5383008 SGTC_3201 9113999 49.47 µM -0.383633241267037 0.337261620674997 no 2223 0.350625149405483 727 16649224 SGTC_2598 perillyl alcohol 100 µM -0.383862878652682 0.337173305487362 no 2224 0.35054004050158 704 10819 An apoptosis inducer. SGTC_2988 9073640 71.4286 µM -0.384144682721387 0.337064940016194 no 2225 0.350435607675737 733 9102229 SGTC_2142 5622915 118.518 µM -0.384485657062178 0.33693383917275 no 2226 0.35030926225187 688 5322196 SGTC_840 0245-0196 390 µM -0.384521831456961 0.336919931682001 no 2227 0.350295859079215 693 3827528 SGTC_304 1310-0298 97 µM -0.385044823909207 0.336718888616923 no 2228 0.350102103127796 725 1550234 SGTC_1786 berberine 21.6 µM -0.385138572918944 0.336682855572478 no 2229 0.350067375527778 711 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3036 9090181 49.47 µM -0.386702384917042 0.336082015531735 no 2230 0.349488275176913 691 25236586 SGTC_3233 9132340 49.47 µM -0.386741860131979 0.336066853971749 no 2231 0.349473661505748 761 17682950 SGTC_2669 eugenol 100 µM -0.387005800265156 0.335965487238373 no 2232 0.349375956959251 715 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_665 3914-0008 307 µM -0.387069084469971 0.335941184586419 no 2233 0.349352532090041 731 1069549 SGTC_2735 sertaconazole 140 nM -0.387126833092545 0.335919008329297 no 2234 0.349331156736611 705 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2510 benzyl isothiocyanate 8.31 µM -0.387410104501838 0.335810236526882 no 2235 0.349226312214394 703 2346 DNA damaging agent; causes G2/M arrest. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.38791398180763 0.335616789494637 no 2236 0.349039845392326 716 5355888 SGTC_2051 5263410 176 µM -0.390031823210502 0.334804191118007 no 2237 0.348256507615113 717 227584 SGTC_692 k241-0027 77.8 µM -0.390318114728356 0.334694402632955 no 2238 0.348150664939891 742 3600480 SGTC_2049 5262831 67.185 µM -0.390631915759354 0.334574080896467 no 2239 0.348034665516495 717 763417 SGTC_2432 5630864 12.22 µM -0.390653101748811 0.33456595809656 no 2240 0.34802683443384 743 5714970 SGTC_1065 prochlorperazine maleate 2.48 µM -0.39187327194397 0.334098270327897 no 2241 0.347575926308384 736 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1705 st027868 56.3335 µM -0.393495126967899 0.333477016581242 no 2242 0.346976911222166 718 292948 SGTC_1330 1469-0054 61.8 µM -0.3936810660802 0.333405821486785 no 2243 0.346908260960925 727 7102664 SGTC_2363 9053361 176 µM -0.395365447566587 0.332761154464633 no 2244 0.346286602544659 743 6469797 YMR079W SEC14 SGTC_1376 2910-0861 41.3 µM -0.39559476243536 0.332673426456229 no 2245 0.346202000770277 717 1112859 SGTC_610 4215-0184 155 µM -0.396122838398512 0.332471437542515 no 2246 0.34600720542325 720 5605015 SGTC_793 0488-0545 106 µM -0.397185406960153 0.332065152795025 no 2247 0.345615371295026 703 292548 SGTC_2567 aureobasidin a 60 nM -0.397251053327159 0.332040058654277 no 2248 0.345591168876534 690 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3086 9117350 49.47 µM -0.397884266439735 0.331798043752148 no 2249 0.345357749095745 719 2679265 SGTC_2783 7738165 71.43 µM -0.398086463548297 0.331720778522956 no 2250 0.34528322605893 691 17201110 SGTC_1820 st053765 18.6 µM -0.398429431112279 0.331589737294129 no 2251 0.345156833495873 726 3690829 SGTC_896 0964-0007 44.5 µM -0.398647699364585 0.331506351974658 no 2252 0.345076404899227 702 6756758 SGTC_2770 toltrazuril 17.5 µM -0.398697220354195 0.331487434565206 no 2253 0.34505815812675 707 68591 Kills coccidiodes. SGTC_1763 st044482 94.5 µM -0.399063542580647 0.331347509933408 no 2254 0.344923192243619 735 88505 SGTC_1388 3346-4487 254 µM -0.399096619459794 0.331334876668402 no 2255 0.34491100653873 732 3345614 SGTC_2902 5787006 60.46 µM -0.399398247119215 0.331219682935081 no 2256 0.344799892666878 726 591003 SGTC_1087 pterostilbene 9.05 µM -0.399537036695764 0.331166683579817 no 2257 0.344748769732203 719 5281727 Similar to reservatol, lowers cholesterol. SGTC_1632 st005650 90 µM -0.400189912929369 0.330917416159459 no 2258 0.344508321785359 711 2759605 SGTC_91 0417-1751 58.384 µM -0.401209218572139 0.330528396259721 no 2259 0.344133047085204 727 6795624 SGTC_1183 1254-0324 198 µM -0.403299355973649 0.329731264241353 no 2260 0.343364007731354 708 5799357 SGTC_581 0958-0271 211 µM -0.403751573931956 0.329558899912487 no 2261 0.343197705079633 723 4591145 SGTC_2915 7971052 15.16 µM -0.404553949741729 0.329253160911686 no 2262 0.34290270701205 729 5741558 SGTC_3277 9138724 49.47 µM -0.405938331827425 0.328725921449992 no 2263 0.342393956189124 714 15943418 SGTC_2104 5389443 200 µM -0.406353566078207 0.328567846598894 no 2264 0.342241416164895 740 2244536 SGTC_2928 9011484 9.79 µM -0.407028718875163 0.328310889274622 no 2265 0.341993447685376 731 2994751 SGTC_1814 st052110 31.539 µM -0.408718031652207 0.327668307406678 no 2266 0.341373299717792 751 674163 SGTC_370 0180-0345 38.7 µM -0.409278903849319 0.327455075171292 no 2267 0.34116749769557 695 3989527 SGTC_87 0100-0052 35.5 µM -0.409570160643756 0.327344367440212 no 2268 0.341060644854237 743 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_985 1493-0307 8.71 µM -0.411481592536527 0.326618202644957 no 2269 0.340359718015361 730 3278274 SGTC_661 1304-0007 33.6 µM -0.412784811233304 0.326123477939376 no 2270 0.339882140289184 703 3117130 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.413411001621415 0.325885873803704 no 2271 0.339652757776224 727 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2828 7998861 71.43 µM -0.413808750764938 0.325734987015896 no 2272 0.339507087394432 713 2988188 SGTC_1334 1486-0610 236 µM -0.416123017072537 0.324857633149231 no 2273 0.338659994023181 693 3742339 SGTC_754 3474-0146 171 µM -0.418039589420542 0.32413178214645 no 2274 0.337959086071932 707 24762078 SGTC_2467 5474540 200 µM -0.418122113690885 0.324100543246772 no 2275 0.337928918785595 704 5413519 SGTC_1443 4112-3303 14 µM -0.419678071765991 0.323511779832223 no 2276 0.337360323163276 728 704433 SGTC_791 1348-1292 225 µM -0.419951388557151 0.323408404266259 no 2277 0.337260482975039 754 5437054 SGTC_343 4130-2827 29.8 µM -0.420205988588132 0.323312120130874 no 2278 0.337167490161157 705 1118244 SGTC_1234 0326-0494 15.5 µM -0.42111796543042 0.322967327677367 no 2279 0.336834471746957 752 1547813 SGTC_1305 1181-0477 144 µM -0.421434001225326 0.322847879018213 no 2280 0.336719097609305 707 6252086 SGTC_255 tunicamycin 200.472 nM -0.421910901678036 0.322667664664873 no 2281 0.336545026236189 742 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_166 k072-0058 166.424 µM -0.422291902880418 0.322523719289553 no 2282 0.336405983798187 756 5846229 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.422511228563727 0.322440868311498 no 2283 0.336325953308167 720 140250 A respiratory chain inhibitor. SGTC_901 1112-0062 60.1 µM -0.423501192436283 0.322067016067141 no 2284 0.335964814369371 715 1908457 SGTC_1283 0922-0125 16.4 µM -0.423501234218553 0.322067000292184 no 2285 0.335964799130386 711 3360884 SGTC_939 1165-0479 45.3 µM -0.425385869236694 0.321355780069709 no 2286 0.335277702706093 734 1377347 SGTC_199 4063-0024 41.6 µM -0.425705986555226 0.32123503972362 no 2287 0.335161049632853 731 306215 SGTC_1157 4092-0394 27.6 µM -0.425978092561409 0.321132422912641 no 2288 0.335061904728342 718 3659885 SGTC_910 3454-3003 490 µM -0.427102097105445 0.320708682310581 no 2289 0.334652482784963 757 820824 SGTC_3041 9091929 49.47 µM -0.427362065535011 0.320610709550047 no 2290 0.334557816488609 727 25236887 SGTC_1877 wortmannin 25 µM -0.427812949312341 0.320440817288996 no 2291 0.334393654195935 742 312145 A covalent inhibitor of PI 3-kinase. SGTC_2651 TUB2.036 5 µM -0.428181958831671 0.320301803104305 no 2292 0.334259325064498 725 15992207 YFL037W TUB2 SGTC_672 1441-0018 53.7 µM -0.430010820209891 0.319613202361878 no 2293 0.333593885147117 721 251141 SGTC_3262 9137218 49.47 µM -0.430067146195348 0.319592004420296 no 2294 0.333573398963577 721 17650664 SGTC_1656 st012921 11 µM -0.430483686166334 0.319435260439454 no 2295 0.333421915658741 743 6732821 SGTC_2699 st077704 54.6 µM -0.431793331563249 0.31894265116921 no 2296 0.332945813289817 728 645852 SGTC_3071 9117417 49.47 µM -0.433147335612177 0.318433692901181 no 2297 0.332453867978826 727 45595590 YGL055W OLE1 SGTC_2359 9039622 200 µM -0.433319608939069 0.318368961404967 no 2298 0.332391297212941 734 6463596 SGTC_2583 asiatic acid 100 µM -0.433599076495093 0.318263963600136 no 2299 0.332289802757531 756 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2415 st077333 57.7 µM -0.437266598655925 0.31688740691978 no 2300 0.330959007890502 753 2766255 SGTC_900 1112-0045 141 µM -0.437928227378816 0.316639342135012 no 2301 0.330719156323506 729 56211 YIL048W NEO1 SGTC_2103 5378138 10 µM -0.438908660534299 0.316271899467619 no 2302 0.33036386057471 747 244142 SGTC_3162 9099653 49.47 µM -0.439003160391589 0.316236492779646 no 2303 0.330329623173636 719 25237511 SGTC_1023 4482-3888 16 µM -0.439356826945375 0.316103997890241 no 2304 0.330201502003229 737 3303168 SGTC_1126 isoteolin 1.0172 µM -0.439556172510207 0.316029327021684 no 2305 0.330129294765725 716 133323 SGTC_3209 9113616 49.47 µM -0.440336584444133 0.315737072513022 no 2306 0.329846673720056 760 16649353 SGTC_698 k064-0052 127 µM -0.440653853375066 0.315618292184909 no 2307 0.329731804619817 747 5088751 SGTC_3059 1327-0034 3 µM -0.440659656547968 0.315616119748675 no 2308 0.32972970369613 720 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.440848740458992 0.315545339071484 no 2309 0.329661252554901 734 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2412 st077135 33.4 µM -0.441939774234241 0.315137059454776 no 2310 0.329266393876347 774 13258915 SGTC_186 3455-3465 67.277 µM -0.443483816581483 0.314559643714618 no 2311 0.328707911156795 752 755278 SGTC_1834 st055981 52.8 µM -0.443591666977162 0.314519328505095 no 2312 0.328668915758613 743 471719 YDL150W RPC53 SGTC_1433 4060-0023 7.6 µM -0.444292874271033 0.31425726641225 no 2313 0.328415426199438 719 3840627 SGTC_2971 9092186 9.93 µM -0.444588221935164 0.314146914182895 no 2314 0.32830868033098 699 25236400 SGTC_248 streptozotocin 5.23457 mM -0.444995878250296 0.313994626800268 no 2315 0.328161366394503 772 5300 DNA alkylating agent. SGTC_2062 5245942 200 µM -0.446055754249698 0.313598839235139 no 2316 0.327778486250075 728 1376160 SGTC_861 0443-0273 110 µM -0.447865503824174 0.312923523685175 no 2317 0.327125132826352 737 6149169 SGTC_594 1487-1584 10.8 µM -0.448082875656832 0.312842452636275 no 2318 0.327046693106518 769 5013332 SGTC_1513 0337-0559 19 µM -0.449150513816751 0.312444397520958 no 2319 0.326661541469164 717 775073 SGTC_1658 st012944 20 µM -0.449366557664826 0.312363874955222 no 2320 0.326583625865492 761 24207260 SGTC_1004 4084-0029 199 µM -0.450695418691311 0.311868787012864 no 2321 0.326104542345134 715 716894 YLR208W SEC13 SGTC_2496 diffractaic acid 79.83 µM -0.452336548617329 0.311257827320116 no 2322 0.325513274986512 726 94870 An apoptosis inducer which activates caspases. SGTC_2756 carbadox 75.1 µM -0.454437687632251 0.310476374015953 no 2323 0.324756915899715 739 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1021 4476-0760 85.3 µM -0.456201567435719 0.309821013399085 no 2324 0.324122519193684 726 746768 SGTC_1402 3909-7673 35.9 µM -0.45646477098703 0.309723273187132 no 2325 0.324027899164747 720 5328014 SGTC_3187 9109394 49.47 µM -0.456803689165707 0.309597436284337 no 2326 0.32390607694456 732 17098090 SGTC_1193 1488-0126 41.5 µM -0.458435365046243 0.308991924033013 no 2327 0.323319844439918 712 1384710 SGTC_1993 st073995 70.8 µM -0.460728574352183 0.308141794695487 no 2328 0.322496675823747 741 3098394 SGTC_3282 9108498 15.4605 µM -0.46139269931087 0.307895784770745 no 2329 0.322258444221432 753 16459645 SGTC_1882 5615643 20 µM -0.461679081904347 0.307789727508504 no 2330 0.322155736999901 726 2253075 SGTC_2657 nystatin 74.44 µM -0.462142650505973 0.307618086247005 no 2331 0.321989513209153 742 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1565 sinapyl alcohol 95.1 µM -0.462161096874885 0.307611257151304 no 2332 0.321982899551622 749 5280507 A phenol propionate derived from cinnamic acid. SGTC_2837 9008476 45.46 µM -0.46382079142773 0.306997088826451 no 2333 0.321388072954567 780 2992805 SGTC_2137 5261020 140 µM -0.463896268151292 0.306969171592376 no 2334 0.321361033328821 735 763655 SGTC_3303 9125618 40.5795 µM -0.464648319393633 0.306691064994437 no 2335 0.321091661812058 750 22695467 SGTC_2840 9008771 71.43 µM -0.464776623898972 0.306643629426199 no 2336 0.3210457147912 708 2992978 SGTC_1795 st049545 62.3 µM -0.465837046510573 0.306251703731134 no 2337 0.320666072677655 707 5291882 SGTC_2663 amphotericin b 100 µM -0.466319003186473 0.306073648717975 no 2338 0.320493589222008 745 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_432 NS 1619 61.3 µM -0.466453078230655 0.306024123914856 no 2339 0.32044561311237 728 4552 A K+/calcium channel activator. SGTC_3332 9141069 11.198 µM -0.466777994424593 0.305904120684492 no 2340 0.320329360709017 736 17332883 SGTC_276 colchicine 750 µM -0.467098227683091 0.305785867415523 no 2341 0.320214801072914 778 2833 A microtubule depolymerizer. SGTC_1771 st048882 4.1505 µM -0.468597971787302 0.305232323089854 no 2342 0.319678513653971 743 4580403 SGTC_41 0478-0632 82.643 µM -0.46952206979156 0.304891466992824 no 2343 0.319348256726799 779 3750424 SGTC_2447 5741742 33.78 µM -0.470786448549382 0.30442537162588 no 2344 0.318896621388204 734 1776504 SGTC_1669 st015249 58.4 µM -0.471748835551727 0.304070813971906 no 2345 0.318553037430324 756 722793 SGTC_857 0438-0306 1.35 µM -0.471887633131762 0.304019694073074 no 2346 0.318503497854781 736 4686136 SGTC_272 doxorubicin 8.13 µM -0.47237006975681 0.303842039865574 no 2347 0.318331332014807 720 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2497 7-hydroxyflavone 100 µM -0.472726772021429 0.303710716318944 no 2348 0.318204061876747 743 5281894 SGTC_2541 muurolladie-3-one 83.07 µM -0.473208069227981 0.303533562045491 no 2349 0.318032370706494 770 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_660 4031-1742 102 µM -0.474069452624224 0.303216622175832 no 2350 0.317725190581466 739 6738706 SGTC_1422 4031-0024 15.5 µM -0.474908999212689 0.302907859474925 no 2351 0.317425918418994 767 782427 SGTC_1757 st041620 31.8375 µM -0.475842440768335 0.302564730058771 no 2352 0.317093315695784 746 5289815 SGTC_1708 st033234 31.827 µM -0.477655143036393 0.30189888607705 no 2353 0.316447838015435 742 674664 SGTC_89 0302-0250 142.109 µM -0.47938564276975 0.301263851827409 no 2354 0.315832152690806 759 4203518 YLR208W SEC13 SGTC_1340 1486-1359 257 µM -0.479674921698201 0.301157755063721 no 2355 0.31572928144235 745 4309068 SGTC_415 dibenzyl ketone 100 µM -0.480801954268741 0.300744562043069 no 2356 0.315328630587751 771 7593 SGTC_1950 st077106 7.18 µM -0.481779724595279 0.300386298965927 no 2357 0.314981217056662 716 13831864 SGTC_1862 st057513 3.81 µM -0.483409956266512 0.299789397890079 no 2358 0.314402340123022 753 5393163 SGTC_2691 st077356 60.2 µM -0.484057205929347 0.299552559744848 no 2359 0.314172635447959 758 2839272 SGTC_1606 st000094 49.2 µM -0.485345845659768 0.299081280232114 no 2360 0.313715519946322 747 1242210 SGTC_341 1486-1430 230 µM -0.486050850770122 0.29882358929005 no 2361 0.31346555640819 767 2054753 YPL210C SRP72 SGTC_3131 9127911 49.47 µM -0.487018870806302 0.298469926546709 no 2362 0.313122478987769 763 45595681 SGTC_888 0916-0002 6.97 µM -0.4879015606771 0.298147604986885 no 2363 0.312809784502708 738 2802138 YIL048W NEO1 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.489043568835915 0.297730826637385 no 2364 0.312405425850685 753 688662 SGTC_2023 5144124 124 µM -0.490177059972567 0.297317419623019 no 2365 0.31200430612659 761 2830192 SGTC_1258 0671-0043 57.1 µM -0.490835565602659 0.29707736988224 no 2366 0.311771376517117 780 4298767 SGTC_542 3381-0244 89.3 µM -0.491113422239446 0.296976107421433 no 2367 0.31167311438029 781 1112843 SGTC_336 4111-0029 111 µM -0.491868109035527 0.29670114802994 no 2368 0.311406292135725 759 3131175 SGTC_2903 5923464 63.88 µM -0.493079219224115 0.296260141089974 no 2369 0.310978306773437 766 2876576 SGTC_2602 kawain 100 µM -0.493142284371388 0.296237185134493 no 2370 0.310956027637424 763 5369129 SGTC_3183 9108214 49.47 µM -0.493240564716822 0.296201412338338 no 2371 0.310921309347394 755 4974831 SGTC_7 0192-1582 4.227 µM -0.494189760045527 0.295856019344822 no 2372 0.310586085432613 774 252616 SGTC_1992 st073643 23.3 µM -0.49724946160312 0.294743917029319 no 2373 0.309506572892705 771 3161292 SGTC_2918 7977171 22.06 µM -0.497663555404577 0.294593555570846 no 2374 0.309360599772843 763 2236483 SGTC_1678 st019265 80.2 µM -0.499480577321837 0.293934196085375 no 2375 0.308720433181533 773 5367020 SGTC_1016 4226-1401 38 µM -0.499973966807925 0.29375527318299 no 2376 0.308546704169912 760 2901613 SGTC_2802 7925815 54.55 µM -0.500052830204312 0.293726678810906 no 2377 0.308518939288506 756 1262923 SGTC_283 0987-0079 11.7 µM -0.500451711752133 0.29358207166298 no 2378 0.308378524643585 751 411556 SGTC_2931 9014674 55.67 µM -0.501115505958434 0.293341498416213 no 2379 0.308144917340713 750 2996810 SGTC_189 3970-0742 2.116 µM -0.501971202330738 0.293031510569334 no 2380 0.307843889069726 774 2891807 SGTC_2851 9015922 71.43 µM -0.502334301444542 0.29290001883237 no 2381 0.307716192282067 785 2996893 SGTC_3150 9097574 49.47 µM -0.5025077705368 0.292837208869941 no 2382 0.307655193892818 768 17217476 SGTC_2511 berberine 10.47 µM -0.502966518555104 0.292671134803921 no 2383 0.307493906113017 778 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1958 st076513 41.9 µM -0.503324379841721 0.292541613718952 no 2384 0.307368114177697 763 732122 YGL099W LSG1 SGTC_2314 7727897 200 µM -0.503389665209241 0.292517987795374 no 2385 0.30734516814049 744 900724 SGTC_354 2783-3500 4.88 µM -0.504945222726685 0.291955314275611 no 2386 0.306798655040356 769 6740761 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.505001610186377 0.291934927372432 no 2387 0.30677885252082 773 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3164 9100705 49.47 µM -0.505029074512574 0.291924997877049 no 2388 0.306769207622036 755 17174235 SGTC_3100 9120536 49.47 µM -0.506495795385255 0.291394945963615 no 2389 0.30625432030802 778 16421196 SGTC_2325 6158266 200 µM -0.507940459625314 0.290873304380832 no 2390 0.305747549674683 741 3623240 SGTC_3348 9149464 3.537 µM -0.507968245525761 0.290863275684858 no 2391 0.305737806360076 747 1951442 SGTC_3091 9116372 49.47 µM -0.508633297842684 0.290623288249224 no 2392 0.305504642300182 768 17169793 SGTC_2619 obliquin 87.91 µM -0.512452410281342 0.289246939187638 no 2393 0.304167209354751 769 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1174 0739-0097 51.1 µM -0.512504266248528 0.289228272200106 no 2394 0.304149067631151 764 728447 SGTC_710 3448-4187 58 µM -0.512809851512207 0.289118279848067 no 2395 0.304042168929864 745 3946412 SGTC_200 k038-0079 37.545 µM -0.514857270664131 0.288381839735978 no 2396 0.303326380808915 760 3436683 SGTC_398 bronopol 33.3 µM -0.515125153169708 0.288285550026034 no 2397 0.303232783469056 757 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1913 st060213 96.1 µM -0.516322498424761 0.287855352654659 no 2398 0.302814592585171 779 688959 SGTC_2194 5927483 104.545 µM -0.516426692907888 0.287817930685393 no 2399 0.30277821330859 732 760979 SGTC_25 0118-0223 35.662 µM -0.516615904789357 0.287749980168699 no 2400 0.302712155397852 776 5333628 SGTC_1855 st056195 39.6 µM -0.516711075706779 0.287715804878832 no 2401 0.302678931637563 743 4028379 SGTC_1163 k060-0048 49.9 µM -0.517455260364702 0.287448638908904 no 2402 0.302419196308154 745 6809982 SGTC_2331 7980721 200 µM -0.517985702868014 0.287258279077167 no 2403 0.302234122301736 755 2981221 SGTC_2183 6420625 130.508 µM -0.518969444465089 0.286905401861799 no 2404 0.301891024618264 758 2897619 SGTC_2000 st075254 36.4 µM -0.520215086379916 0.286458873492349 no 2405 0.301456835746114 729 17234175 SGTC_2330 7979373 200 µM -0.521535574068812 0.28598587537232 no 2406 0.300996865287201 753 1863007 SGTC_1249 0481-0015 10.2 µM -0.522205563061893 0.285746027638694 no 2407 0.300763606551288 794 4227577 SGTC_1844 rapamycin 4 nM -0.524436194953176 0.28494817947838 no 2408 0.299987593662984 780 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.524944923916897 0.284766367174707 no 2409 0.299810739270205 757 688761 SGTC_1169 aniline yellow 25.8 µM -0.526641209223368 0.284160539960469 no 2410 0.299221384557562 774 6051 A DNA damaging agent. SGTC_32 0928-0142 34.1 µM -0.526694453896401 0.284141533640519 no 2411 0.299202893823835 781 2244242 SGTC_29 0299-0004 12.984 µM -0.526748069180795 0.284122395640768 no 2412 0.299184274908694 776 16871 A napthoquinone isolated from Swertia calycina. SGTC_3129 9127257 49.47 µM -0.52785830437458 0.28372623531436 no 2413 0.298798843109378 793 837894 SGTC_624 k048-0052 28 µM -0.527933307448269 0.283699481840236 no 2414 0.298772813009113 752 6835531 SGTC_797 k781-0471 270 µM -0.529033850440373 0.283307058944718 no 2415 0.298390983976433 743 23738129 SGTC_2776 terbinafine 19.92 µM -0.529104330581484 0.283281936566505 no 2416 0.298366538739239 746 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_756 0508-1999 28.3 µM -0.529482838158928 0.283147037259745 no 2417 0.298235273276534 762 6753853 SGTC_934 2950-0684 338 µM -0.529815108439227 0.283028642239598 no 2418 0.298120064471143 779 1121253 SGTC_16 erodoxin 22.806 µM -0.530169350216759 0.282902444481963 no 2419 0.297997259776024 785 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3048 9093155 49.47 µM -0.531889637090802 0.282289981067303 no 2420 0.29740121752244 762 25236002 SGTC_2430 5571206 200 µM -0.533958950821536 0.281554102095896 no 2421 0.296684967365065 781 1731771 SGTC_2823 7987624 58.44 µM -0.534709344529716 0.281287479639958 no 2422 0.296425429405283 814 2239440 SGTC_1931 st074438 57.1 µM -0.53482887247296 0.281245021412414 no 2423 0.296384097999342 814 2787313 SGTC_2168 5727979 200 µM -0.538459686343882 0.279956775350063 no 2424 0.295129864831243 762 695210 SGTC_1627 st003713 25.6 µM -0.538795561485074 0.279837748501133 no 2425 0.295013963284918 746 16195070 YER133W GLC7 SGTC_1982 st072467 71.9 µM -0.539550670915592 0.279570243794012 no 2426 0.294753471765628 784 3163533 SGTC_153 4077-0274 519.67 µM -0.540056090347426 0.279391263529971 no 2427 0.294579175547113 754 3121976 SGTC_1238 0333-0287 48.8 µM -0.542529790440208 0.278516075055151 no 2428 0.293726795420893 761 7226 SGTC_151 3013-0144 2.285 µM -0.542981957709081 0.278356243972322 no 2429 0.293571112455445 780 906558 YHR107C CDC12 SGTC_2087 5276107 200 µM -0.543296680507523 0.278245022848891 no 2430 0.293462774717547 776 144405 SGTC_2771 fluoxetine 41.05 µM -0.544106375385856 0.277958981221229 no 2431 0.293184136771385 790 3386 A selective serotonin reuptake inhibitor. SGTC_2811 7967822 32.47 µM -0.544789505173635 0.277717763019176 no 2432 0.29294914874981 755 2232244 SGTC_349 k015-0014 24 µM -0.546854802607971 0.27698911355205 no 2433 0.292239244599613 756 2196908 SGTC_890 0929-0006 47.2 µM -0.546922724288605 0.276965166275396 no 2434 0.292215911496357 775 1378169 SGTC_3056 9094900 49.47 µM -0.547816390694413 0.276650179041752 no 2435 0.291908991447982 779 25236784 SGTC_2593 nobiletin 86.24 µM -0.548437767960763 0.276431268056376 no 2436 0.291695674683171 765 72344 An anti-infammatory. SGTC_296 1222-0039 74.9 µM -0.548469290302391 0.27642016501134 no 2437 0.291684855103964 772 5984176 SGTC_1871 st057448 67.3 µM -0.549636624483349 0.276009151548965 no 2438 0.291284316639734 809 691747 SGTC_984 1492-0255 2.91 µM -0.550418155099612 0.275734145728452 no 2439 0.291016299559778 784 1585198 SGTC_325 2810-4341 181 µM -0.553472751575834 0.274660584709239 no 2440 0.289969867015641 761 774970 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.553865362150202 0.274522748408137 no 2441 0.289835495970659 775 2724278 An inhibitor of dopamine biosynthesis. SGTC_2740 felodipine 17.08 µM -0.556087180553395 0.273743364110006 no 2442 0.289075629110674 746 3333 L-type calcium channel blocker SGTC_2175 5807670 165.306 µM -0.556866476982702 0.273470256791869 no 2443 0.28880933011597 769 241186 SGTC_632 0781-2353 4.65 µM -0.557521145672151 0.273240930026184 no 2444 0.28858570785961 789 6811515 YHR007C ERG11 SGTC_1267 0828-0272 9.49 µM -0.558019718387517 0.273066346730486 no 2445 0.288415459726508 778 745334 SGTC_1964 st076914 61 µM -0.558319562974573 0.272961377932751 no 2446 0.288313094293473 802 24208661 SGTC_2801 7907800 81.82 µM -0.55903121797354 0.272712323759101 no 2447 0.288070207467458 805 6620925 SGTC_1239 0337-0584 35.4 µM -0.561502320981306 0.271848401297503 no 2448 0.287227574261635 785 914301 YML130C ERO1 SGTC_1613 st002381 52.1 µM -0.562619131572826 0.271458400356659 no 2449 0.286847130822673 775 551167 SGTC_2747 doxorubicin 7.63 µM -0.56307916642015 0.271297832878647 no 2450 0.286690488638878 751 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_40 0327-0103 19.753 µM -0.563222828516959 0.271247699724995 no 2451 0.286641579907545 760 409036 SGTC_798 1287-0182 476 µM -0.563566923594655 0.271127641102628 no 2452 0.286524451295645 801 1649755 SGTC_364 0083-0097 67.7 µM -0.565810148281145 0.270345604989203 no 2453 0.285761423504235 791 5207356 SGTC_471 1-acyl-paf 4 µM -0.565954476424129 0.27029532774541 no 2454 0.285712363724539 765 16759367 SGTC_1105 epirubicin 18.1 µM -0.568878038795267 0.269277901462334 no 2455 0.284719454978662 772 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2678 equilin 100 µM -0.57092684157057 0.268566045912328 no 2456 0.28402461759175 760 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_575 k072-0246 11.9 µM -0.571146672215321 0.268489722085728 no 2457 0.283950111757836 789 6796779 SGTC_1417 3966-0327 90.4 µM -0.572791040885466 0.267919153636371 no 2458 0.283393092949289 790 651118 SGTC_2043 5101342 149 µM -0.574720293997425 0.267250514446781 no 2459 0.282740240073918 791 678451 SGTC_2202 7226349 200 µM -0.574721738429031 0.267250014152346 no 2460 0.282739751553868 762 844334 SGTC_1382 3002-2117 298 µM -0.575687835784599 0.266915501842568 no 2461 0.282413099425009 823 1497314 SGTC_3028 9087778 49.47 µM -0.576167042623924 0.266749654441546 no 2462 0.282251139719662 771 17217395 SGTC_344 k064-0035 6.43 µM -0.576301051249408 0.266703285078772 no 2463 0.282205856216614 777 5088750 SGTC_2443 5493264 126.67 µM -0.577194070163435 0.266394388764705 no 2464 0.281904181200854 798 5340055 SGTC_1988 st071872 53.4 µM -0.577937337880523 0.26613742966848 no 2465 0.281653212890111 771 16414116 SGTC_1787 fluconazole 80 µM -0.578125840032373 0.26607228152808 no 2466 0.281589581262936 776 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_559 1550-0661 158 µM -0.578278302441486 0.266019594974985 no 2467 0.281538120444214 782 5830875 SGTC_80 0159-0065 512.242 µM -0.578907334003723 0.265802275943222 no 2468 0.28132585065313 778 1548079 SGTC_1960 st011366 51.8 µM -0.579701326542978 0.265528094412943 no 2469 0.281058024319772 799 3972846 SGTC_2881 9058953 51.95 µM -0.580450145368936 0.265269643796076 no 2470 0.280805548725443 753 17122249 SGTC_920 mycophenolic acid 780.421 nM -0.582203591607498 0.264664951734571 no 2471 0.280214777214952 776 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1411 3909-8223 150 µM -0.582273141869995 0.264640981150243 no 2472 0.280191356745536 796 X1411 SGTC_3317 9138495 8.753 µM -0.582454953922393 0.264578324617391 no 2473 0.280130137537436 806 17020139 SGTC_3160 9100216 49.47 µM -0.582990857703912 0.264393684007401 no 2474 0.279949727346055 782 17191039 SGTC_538 2922-0838 53.3 µM -0.583240863763693 0.264307569211563 no 2475 0.279865582929423 780 777039 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.584066438153554 0.264023300901539 no 2476 0.279587806930355 802 4620898 SGTC_639 0833-0042 114 µM -0.584443353005323 0.263893570416685 no 2477 0.279461033196289 802 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1644 st010134 20.9 µM -0.584542866339504 0.263859324302533 no 2478 0.279427566961428 807 3818134 SGTC_2245 6637752 200 µM -0.585537037764096 0.263517318624712 no 2479 0.279093335009734 771 681890 SGTC_961 1252-1571 372 µM -0.586128696111966 0.263313889217884 no 2480 0.278894516830193 808 6813498 SGTC_1361 1608-0041 5.61 µM -0.586342745532675 0.263240312539924 no 2481 0.278822605615299 798 X1361 SGTC_572 0960-0087 17.7 µM -0.587464012403564 0.262855063430777 no 2482 0.278446056645709 806 6796365 SGTC_957 1187-1561 14.1 µM -0.588953759547877 0.262343656844503 no 2483 0.277946146565693 796 1538454 SGTC_2769 toremifene 3.73 µM -0.58944184165342 0.262176216883452 no 2484 0.277782457599915 782 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_250 brefeldin a 552.239 µM -0.590028071768133 0.261975178971966 no 2485 0.277585914804181 789 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_853 0419-0306 21 µM -0.590108096810269 0.261947741840887 no 2486 0.277559090431383 790 762713 SGTC_2489 cantharidin 73.42 µM -0.590206930224532 0.261913858164847 no 2487 0.277525963245543 791 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2148 5546263 113.568 µM -0.590704229573152 0.261743400038719 no 2488 0.277359306760182 779 792097 SGTC_1973 st070275 50.2 µM -0.593497871469737 0.260786889045502 no 2489 0.276424003525873 784 17118334 SGTC_2191 5911152 200 µM -0.593898315149278 0.260649929230723 no 2490 0.276290062997848 786 2875902 SGTC_1761 st044296 37 µM -0.594778233934984 0.260349109364924 no 2491 0.275995859391018 796 1826700 SGTC_1667 st014849 34.6 µM -0.595134347163849 0.260227414972487 no 2492 0.275876835563009 802 5348460 SGTC_162 k030-0015 37.8 µM -0.595244368339525 0.260189823420344 no 2493 0.275840068253049 814 1809920 YMR134W ERG29 SGTC_3062 9077494 49.47 µM -0.595670459780732 0.26004426478103 no 2494 0.275697698058391 757 16459633 SGTC_330 1488-0319 80.1 µM -0.59574782660968 0.260017839723279 no 2495 0.27567185130763 796 6846614 SGTC_1449 4112-4002 201 µM -0.596210087643845 0.2598599808313 no 2496 0.27551744372558 785 2059539 SGTC_2184 6075246 200 µM -0.599067248096869 0.258885378999035 no 2497 0.274564020577961 798 2267320 SGTC_3306 9127676 59.7925 µM -0.600921081838647 0.258254033562739 no 2498 0.273946275459421 785 41905287 SGTC_391 gliotoxin 8.33 µM -0.600951739647474 0.258243599388168 no 2499 0.273936065265901 811 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_712 r015-0009 80.6 µM -0.603700347126426 0.257309018480209 no 2500 0.273021441655344 787 6813872 YLR060W FRS1 SGTC_1253 0550-0034 176 µM -0.603747371259481 0.257293044653112 no 2501 0.273005807137427 790 5969915 SGTC_1990 st072050 59.8 µM -0.605434811579245 0.256720172186546 no 2502 0.272445063260637 791 17233948 SGTC_2150 5556613 200 µM -0.606179245876906 0.256467653973126 no 2503 0.272197866413279 804 743190 SGTC_1567 st069303 68.4 µM -0.606437387386511 0.256380120484938 no 2504 0.272112173982533 805 5581319 SGTC_1666 st014829 29 µM -0.607297335290403 0.256088632166398 no 2505 0.271826803218638 796 3858230 SGTC_1721 st082152 9.2685 µM -0.608404282245888 0.255713675548618 no 2506 0.271459686017601 802 5296051 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.608673156738543 0.255622642864571 no 2507 0.271370551516345 777 6708561 SGTC_526 4469-0568 170 µM -0.609109327219183 0.255475004878774 no 2508 0.271225987798097 780 2901964 SGTC_1711 st032263 62.8 µM -0.609800454604462 0.255241158585196 no 2509 0.270997000169567 810 3958979 SGTC_2641 levomentholum 100 µM -0.610022166580534 0.255166164981859 no 2510 0.270923561935761 801 16666 SGTC_1851 st056236 18.9 µM -0.610192441470165 0.255108577687296 no 2511 0.270867168084421 785 5393171 SGTC_2479 5617353 43.85 µM -0.610276586925278 0.255080122042683 no 2512 0.270839301861838 816 2731746 SGTC_859 0439-0102 54.6 µM -0.610977839540508 0.254843042566933 no 2513 0.270607125597473 811 610143 SGTC_1904 st060225 78 µM -0.611411235311062 0.25469657781934 no 2514 0.270463683218988 775 66595 SGTC_1804 st050076 49.1 µM -0.61201176783123 0.254493702608114 no 2515 0.270264985877087 800 3895976 SGTC_1496 4469-0713 57.4 µM -0.612783557239332 0.25423309683402 no 2516 0.270009732234368 810 746691 SGTC_1123 mangostin 811.285 nM -0.613489426196291 0.253994872615303 no 2517 0.269776386105706 760 5281650 An antioxidant. SGTC_1596 piperlongumine 63 µM -0.61423816695279 0.253742307632389 no 2518 0.269528977838446 791 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_47 0149-0135 24.25 µM -0.614393442805682 0.253689946547564 no 2519 0.269477683891943 786 5239155 SGTC_1959 st077091 55.8 µM -0.616879105108143 0.252852521188968 no 2520 0.268657234918385 821 821356 YKL052C ASK1 SGTC_1275 0867-0008 21.1 µM -0.618453930441315 0.252322712892682 no 2521 0.268138078571176 798 3422836 SGTC_2252 omeprazole 400 µM -0.619891835944676 0.2518394792652 no 2522 0.26766450053498 787 4594 A proton pump inhibitor. SGTC_3054 9094397 49.47 µM -0.62009079610699 0.251772653674723 no 2523 0.267599005688156 823 2598354 SGTC_2221 6807166 181.081 µM -0.620098493628823 0.251770068463672 no 2524 0.267596471936126 793 674925 SGTC_462 ag-879 158 µM -0.620844220242363 0.251519682808128 no 2525 0.267351062455864 822 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1899 st063254 59.6 µM -0.621984511965825 0.251137072271475 no 2526 0.266976026114055 805 3093813 SGTC_2375 9072683 200 µM -0.622146598869822 0.251082711052348 no 2527 0.266922738105571 820 16798029 SGTC_735 3076-0345 636 µM -0.622346477742225 0.251015683615619 no 2528 0.266857032934241 796 2888990 SGTC_2810 7959871 45.46 µM -0.622664412213978 0.250909086891698 no 2529 0.26675253678226 804 2974535 SGTC_2685 mycophenolic acid 18.85 µM -0.62388140062114 0.250501277826721 no 2530 0.266352737975164 795 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3181 9108277 49.47 µM -0.625382850267068 0.249998631047757 no 2531 0.265859907567361 825 17097298 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.625525702374334 0.249950835728963 no 2532 0.265813042394318 826 23665772 A membrane-active detergent. SGTC_1968 st069590 43.6 µM -0.627356283807273 0.249338791055437 no 2533 0.265212858474461 813 6384066 SGTC_478 N-arachidonylglycine 10 µM -0.62787253942732 0.249166328012712 no 2534 0.265043720708552 771 5283389 SGTC_792 4534-1957 155 µM -0.628230961247661 0.249046629077262 no 2535 0.264926325331966 803 1717904 SGTC_607 4491-0986 66.8 µM -0.6303934449034 0.248325093313412 no 2536 0.264218599266682 800 698981 YDR232W HEM1 SGTC_1611 st001856 99.4 µM -0.630644252937844 0.24824148071523 no 2537 0.26413657851379 831 647478 SGTC_147 4466-0538 29.23 µM -0.631000410071983 0.248122773383114 no 2538 0.264020128154911 812 6742687 YHR072W ERG7 SGTC_847 0342-0274 5.54 µM -0.632257908081326 0.247703891030543 no 2539 0.263609181649514 807 18097 SGTC_161 4065-0411 162.148 µM -0.63250477459404 0.247621702245765 no 2540 0.263528544767262 810 1906281 YLR208W SEC13 SGTC_2324 6149169 200 µM -0.632659993609021 0.247570032942565 no 2541 0.263477850220326 803 2888231 SGTC_2009 4012297 12.05 µM -0.634118704424498 0.247084738841314 no 2542 0.263001678426029 814 45595307 SGTC_911 3456-4043 236 µM -0.636149445200941 0.246409986056341 no 2543 0.262339510202491 806 914281 SGTC_1609 st001574 46.4 µM -0.636360156843794 0.246340029642473 no 2544 0.262270851907366 825 3960012 SGTC_1045 1348-1485 165 µM -0.636687311178162 0.246231435272572 no 2545 0.262164270160996 799 6810614 SGTC_1670 st016595 4.04 µM -0.637667902090297 0.245906095469798 no 2546 0.261844942044246 835 597879 SGTC_2775 cyproheptadine 69.59 µM -0.639203595558845 0.245397048006835 no 2547 0.261345246683145 814 2913 A selective serotonin reuptake inhibitor. SGTC_2741 miltefosine 3.04 µM -0.639763902183858 0.245211460204379 no 2548 0.261163051981398 803 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1292 0kpi-0043 232 µM -0.641110906225834 0.244765607175552 no 2549 0.260725314416029 814 3333905 SGTC_1159 4092-0538 61.2 µM -0.644038809119183 0.24379799001123 no 2550 0.259775134128511 826 717301 SGTC_1347 1493-0251 600 nM -0.645292973404717 0.24338414465218 no 2551 0.259368672676852 801 3986378 SGTC_2088 5278280 127.392 µM -0.646279639055462 0.243058834665182 no 2552 0.259049135797499 818 791502 SGTC_2948 9070189 9.45 µM -0.646955870727997 0.242836012639265 no 2553 0.258830252232137 796 6473636 YDL196W YDL196W SGTC_121 0557-0495 61.343 µM -0.647181167840455 0.242761800568229 no 2554 0.258757349022778 838 3104427 SGTC_1510 1123-0200 71.5 µM -0.64822812906684 0.242417096372298 no 2555 0.258418705512628 835 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2084 5306078 60.6385 µM -0.648723922385199 0.242253952676184 no 2556 0.258258419463523 838 679340 SGTC_3011 9081274 71.4286 µM -0.649574873388645 0.241974081037896 no 2557 0.257983433919088 811 6625322 SGTC_2825 7998094 58.44 µM -0.649674143687913 0.241941443180375 no 2558 0.257951364532353 805 2987815 SGTC_1273 0849-0096 14.1 µM -0.649958407159665 0.241847996910211 no 2559 0.257859544325238 825 5286025 SGTC_2347 9049783 174.81 µM -0.652085754547321 0.241149293540992 no 2560 0.257172926660895 849 6467988 YPL169C MEX67 SGTC_3188 9110789 49.47 µM -0.652726756591082 0.240938978950067 no 2561 0.256966224867882 825 849217 SGTC_1660 st012960 28.1 µM -0.652855190729333 0.240896851345241 no 2562 0.256924819535713 825 24207266 SGTC_1000 4048-0884 8.67 µM -0.65458815123583 0.240328815977005 no 2563 0.256366477420647 826 13040088 SGTC_60 0986-0278 202 µM -0.654669551475737 0.240302152299657 no 2564 0.256340266655224 848 3110598 SGTC_550 4123-0385 25.7 µM -0.654742885599957 0.240278132160625 no 2565 0.256316654363958 820 5731123 SGTC_115 0527-0192 112.043 µM -0.655644517939829 0.239982915010772 no 2566 0.256026437373673 842 4233931 SGTC_1698 5-fluorocytosine 1.055 µM -0.659456287677475 0.238737033984912 no 2567 0.254801403572513 815 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_177 1327-0068 8.361 µM -0.659792247920881 0.238627394966565 no 2568 0.25469357936351 818 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.660897674535658 0.238266838853387 no 2569 0.254338968751345 822 521171 SGTC_1493 4348-0038 111 µM -0.662029664199523 0.237897928175126 no 2570 0.253976105345258 840 800424 SGTC_173 1273-0061 2.693 µM -0.663574263582366 0.237395055364739 no 2571 0.253481416956852 819 2847414 YPL266W DIM1 SGTC_150 3970-0969 77.2 µM -0.663914241173463 0.237284447810955 no 2572 0.253372600459313 842 6615640 SGTC_1709 st033179 39.1045 µM -0.664456806762222 0.23710798936966 no 2573 0.253198992572202 819 573381 SGTC_472 calcifediol 10 µM -0.665652722556741 0.236719296782843 no 2574 0.252816549412677 820 5283731 A vitamin D metabolite. SGTC_1793 st048256 72.231 µM -0.667738347701988 0.236042273159148 no 2575 0.25215031350938 826 672022 SGTC_2003 4023581 200 µM -0.667872606131113 0.235998727541668 no 2576 0.25210745749873 823 16641307 SGTC_1331 1472-0049 76.2 µM -0.668675276484684 0.235738480383195 no 2577 0.251851320991766 835 24051409 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.670263292523492 0.235224069763658 no 2578 0.251344981392418 819 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1034 k072-0165 12.7 µM -0.671561778235288 0.234803908569202 no 2579 0.250931358926161 834 5835461 SGTC_1665 st014639 11.4 µM -0.672653574979775 0.234450948644967 no 2580 0.250583854611005 825 981133 YIL048W NEO1 SGTC_1132 3456-3614 2.5 µM -0.673618244642708 0.234139331247152 no 2581 0.250277025425546 825 3125502 SGTC_1251 0490-5699 265 µM -0.67423228373455 0.233941097614965 no 2582 0.250081823913326 829 3883818 SGTC_2156 5649887 115 µM -0.674504042319114 0.233853393981009 no 2583 0.249995458320017 834 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_802 4112-3352 742 µM -0.675195310183944 0.233630385821671 no 2584 0.249775842925454 802 704594 SGTC_3249 9135183 49.47 µM -0.676259934310171 0.233287160913229 no 2585 0.249437812937222 804 4902779 SGTC_876 0720-0963 56.8 µM -0.678020032550259 0.232720335847044 no 2586 0.248879495869334 840 765861 SGTC_185 k048-0037 25.491 µM -0.679237937807729 0.232328568027149 no 2587 0.248493556437962 812 6827589 SGTC_1875 nocodazole 6 µM -0.681573064281357 0.231578446926672 no 2588 0.247754475931473 823 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1955 wogonin 32.4 µM -0.681981462738559 0.231447394452855 no 2589 0.247625336245803 807 5281703 A flavanone. SGTC_286 k060-0067 22.9 µM -0.683811342860869 0.230860705554782 no 2590 0.247047151538392 821 5985051 SGTC_725 1497-0963 19 µM -0.683960032731966 0.230813069708408 no 2591 0.247000201952562 822 3549977 SGTC_2850 9015429 58.44 µM -0.684850173824609 0.230528009602092 no 2592 0.246719235224242 850 6457570 SGTC_408 cantharidin 100 µM -0.684971172772528 0.230489275915913 no 2593 0.246681055980822 820 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2288 7946289 167.31 µM -0.685415322571155 0.230347127694744 no 2594 0.246540938886797 836 1246052 SGTC_1450 4112-4260 37.6 µM -0.68987486178993 0.228922591524962 no 2595 0.245136442787739 833 1633175 SGTC_465 cgp-37157 41 µM -0.691215121351462 0.228495432895553 no 2596 0.244715181274775 808 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2004 4023728 41.89 µM -0.693053285670465 0.227910314231643 no 2597 0.244138056081616 855 360084 YDR527W RBA50 SGTC_2774 tamoxifen 10.92 µM -0.693334564275629 0.227820852939881 no 2598 0.244049808330545 842 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_516 3992-2719 87.3 µM -0.693345824922241 0.227817271877389 no 2599 0.244046275797463 822 5350887 YDR037W KRS1 SGTC_2320 7373003 200 µM -0.695681187408399 0.227075274774864 no 2600 0.243314254767931 820 5415828 SGTC_1590 st077108 57.8 µM -0.696475636085115 0.226823171521787 no 2601 0.243065505045232 811 5489485 SGTC_1997 st073024 93.8 µM -0.697154313782111 0.226607931117586 no 2602 0.242853113338287 829 686268 SGTC_74 000s-0487 160.283 µM -0.697723334818175 0.226427556851048 no 2603 0.242675116033822 802 677548 SGTC_654 1124-0271 80.9 µM -0.697801747030605 0.226402707281788 no 2604 0.242650593195226 832 5403748 SGTC_1233 0325-0408 14.2 µM -0.697899777517266 0.226371642662961 no 2605 0.242619936774002 841 12874 SGTC_584 0986-0246 15.4 µM -0.698257667366329 0.226258252345132 no 2606 0.242508034071332 867 53315 YDR232W HEM1 SGTC_1843 st055809 45.5 µM -0.699465505150439 0.225875809817108 no 2607 0.242130581560323 833 16413835 SGTC_503 tyrphostin 8 294 µM -0.700093607970393 0.22567707566406 no 2608 0.241934423723784 859 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.700224719208269 0.225635604046999 no 2609 0.241893488285638 825 16623 A steroid. SGTC_1333 1482-0047 286 µM -0.700347180191765 0.225596872475264 no 2610 0.241855257016752 844 3811116 SGTC_140 0062-0056 502.533 µM -0.702871971687477 0.22479917827937 no 2611 0.241067769833168 825 3758964 SGTC_2993 9054257 71.4286 µM -0.703067711262693 0.224737402293208 no 2612 0.241006776580575 838 6470217 YGL055W OLE1 SGTC_1873 rapamycin 2 nM -0.704317403792109 0.224343222668772 no 2613 0.240617565177063 826 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1320 1313-0481 95.3 µM -0.704805504852202 0.224189371847516 no 2614 0.240465641158939 833 6813365 YLR208W SEC13 SGTC_2106 5357045 167.29 µM -0.705593150032407 0.223941230276934 no 2615 0.240220592666909 831 668842 SGTC_843 0310-0051 143 µM -0.705886875296111 0.223848734352168 no 2616 0.24012924508284 846 2065037 SGTC_23 0213-0011 39.996 µM -0.707916773167293 0.223210100653133 no 2617 0.239498471454605 850 627608 SGTC_3195 9113082 49.47 µM -0.707924074132613 0.22320780554283 no 2618 0.239496204375242 829 17018038 SGTC_2171 5739187 198.077 µM -0.708710846513485 0.222960556794571 no 2619 0.239251966261743 829 2262761 SGTC_2369 9071472 200 µM -0.708807886578851 0.222930072083091 no 2620 0.239221851499696 850 17296037 SGTC_3117 9124945 49.47 µM -0.709110359464103 0.222835066786856 no 2621 0.23912799738703 824 17592065 SGTC_631 k072-0230 41.5 µM -0.709235633485104 0.222795725568794 no 2622 0.239089132087755 849 5773147 SGTC_1037 k284-1091 78.7 µM -0.71153522119675 0.222074263510141 no 2623 0.238376316488778 834 3334711 SGTC_518 1021-0119 62.6 µM -0.712221960437992 0.221859067987635 no 2624 0.238163670118676 851 1097762 SGTC_1702 st027038 51 µM -0.713925368723945 0.221325805068429 no 2625 0.237636664727267 830 5521182 SGTC_2753 fluvastatin 17.09 µM -0.71486008191399 0.221033498844555 no 2626 0.237347752566597 861 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1178 0988-0033 191 µM -0.716998272248137 0.220365669170101 no 2627 0.236687581368359 833 5392207 SGTC_1222 0366-0074 1.18 µM -0.71856965640043 0.219875610625497 no 2628 0.236203057524815 849 286520 SGTC_3197 9113331 49.47 µM -0.718693028684433 0.219837161719358 no 2629 0.236165039801782 833 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_368 fentichlor 4.58 µM -0.72043990824917 0.219293161965516 no 2630 0.23562709291941 859 7329 A pesticide. SGTC_1891 st059073 26.2 µM -0.721337384132034 0.219013978071927 no 2631 0.235350980671293 841 688754 SGTC_633 0437-0093 97.7 µM -0.722398201362276 0.218684246239269 no 2632 0.235024846210998 845 2831118 SGTC_3261 9137475 49.47 µM -0.722646411416404 0.218607136842562 no 2633 0.234948573318183 787 17027690 SGTC_487 nimodipine 119 µM -0.722842900595622 0.218546106250521 no 2634 0.234888203522443 828 4497 L-type voltage-gated calcium channels inhibitor SGTC_292 k038-0015 474 µM -0.724440529797604 0.218050238362776 no 2635 0.234397662548415 852 46368540 SGTC_1671 st016596 74.5 µM -0.725429244307114 0.21774368896106 no 2636 0.234094368807954 850 2829167 SGTC_529 4076-0302 30.3 µM -0.726576105192806 0.217388418168514 no 2637 0.23374283519867 854 5816522 SGTC_136 0097-0015 404.482 µM -0.727222718897011 0.217188259937993 no 2638 0.233544765468695 849 4861337 SGTC_2348 9022543 33.42 µM -0.727872778027813 0.21698714253574 no 2639 0.233345734203368 840 3162678 YDL140C RPO21 SGTC_1194 1488-0194 225 µM -0.727917520332546 0.216973303976592 no 2640 0.23333203873145 849 1391452 SGTC_684 1140-0066 328 µM -0.729287923330462 0.216549692689228 no 2641 0.232912779004368 841 6813534 SGTC_1335 1486-0900 202 µM -0.730334605487084 0.21622647071443 no 2642 0.232592840183068 838 X1335 SGTC_3200 9114385 49.47 µM -0.730785559254142 0.216087299525467 no 2643 0.232455072712503 824 17018030 YLR208W SEC13 SGTC_806 3966-4455 5.86 µM -0.731311101392807 0.215925174713094 no 2644 0.232294575591351 840 714982 SGTC_2648 atorvastatin 78.68 µM -0.731358475397507 0.215910563741511 no 2645 0.23228011091108 840 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1962 st076595 64.5 µM -0.731828869698094 0.2157655170006 no 2646 0.232136512858936 843 279619 SGTC_595 3909-8003 73.7 µM -0.732451917116667 0.215573486433088 no 2647 0.231946390224066 855 699517 SGTC_1800 st050079 29.0735 µM -0.732899938003973 0.21543546238715 no 2648 0.231809730467193 849 3645560 SGTC_1365 1672-3266 55.4 µM -0.732918989164505 0.215429594336931 no 2649 0.231803920288387 836 6415873 SGTC_2256 7954252 200 µM -0.732935056424481 0.215424645446014 no 2650 0.231799020195722 870 2972920 SGTC_2499 avocadenofuran 51.48 µM -0.733421743910603 0.215274771661824 no 2651 0.231650620633044 852 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_203 k066-0004 30.888 µM -0.735643207356696 0.214591448305816 no 2652 0.230973930230185 856 6795412 SGTC_3148 9097893 49.47 µM -0.736447534655643 0.214344348020673 no 2653 0.230729192699017 813 17174100 SGTC_142 0335-0849 62.6745 µM -0.736943373086082 0.21419210220085 no 2654 0.2305783931455 830 3889043 YPR107C YTH1 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.738413251541134 0.213741149963116 no 2655 0.23013168218161 866 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3179 9107801 49.47 µM -0.738603365439053 0.213682864270409 no 2656 0.230073940022884 823 4818259 SGTC_1657 st012939 43.4 µM -0.738661314595757 0.213665099884402 no 2657 0.230056341083861 836 24207257 SGTC_1119 parthenolide 318.541 nM -0.740457695139843 0.213114844036012 no 2658 0.229511160881846 877 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3055 9094636 49.47 µM -0.740536798048069 0.213090632753042 no 2659 0.229487170739243 853 25236176 SGTC_1386 3228-0095 33.8 µM -0.741152771668366 0.212902154616565 no 2660 0.229300407801418 839 870181 SGTC_2255 7941087 197.44 µM -0.741566325218881 0.212775668409665 no 2661 0.229175066367481 840 935561 SGTC_980 1473-0395 201 µM -0.742180852159627 0.2125877951265 no 2662 0.228988884120086 860 768876 SGTC_170 4197-0004 226 µM -0.742607560389354 0.212457398824245 no 2663 0.228859654947282 860 218692 SGTC_119 0121-0043 24.815 µM -0.743539889576346 0.212172654188971 no 2664 0.228577440247658 860 1092378 SGTC_554 4483-2211 187 µM -0.743870844900743 0.212071630100851 no 2665 0.228477307576047 862 747107 SGTC_188 3229-0966 278.469 µM -0.746635316078884 0.211228874863743 no 2666 0.227641862265906 852 5722370 SGTC_2777 climbazole 1.536 µM -0.746891080156132 0.211151003906048 no 2667 0.227564655331657 856 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1218 1348-1416 30.7 µM -0.747066283414379 0.211097670529386 no 2668 0.22751177562404 842 6787668 SGTC_838 0109-0203 71.4 µM -0.749633953951713 0.210316955734643 no 2669 0.226737597673816 834 759422 SGTC_176 1486-1328 72.834 µM -0.750733811793762 0.209983057034432 no 2670 0.226406434994933 853 22310231 SGTC_453 enantio-paf c16 10 µM -0.754816697036715 0.208746287897942 no 2671 0.225179487001287 870 13871343 A lipid and platelet activating factor SGTC_1783 st039459 87.517 µM -0.755732943784324 0.208469333511581 no 2672 0.224904664035905 873 729761 SGTC_2923 7992654 58.14 µM -0.757654359824002 0.207889250218137 no 2673 0.224328964161478 839 2985126 SGTC_1356 1502-0781 85.8 µM -0.757851774657036 0.207829703923683 no 2674 0.224269861622935 855 567702 SGTC_2879 9041815 71.43 µM -0.758683291326386 0.207579003895092 no 2675 0.22402101717989 830 4942971 SGTC_790 1575-0012 79.1 µM -0.759603657147673 0.20730172455919 no 2676 0.223745766218759 856 378741 YLR208W SEC13 SGTC_2556 citropten 84.59 µM -0.760511964384375 0.207028292963759 no 2677 0.223474310181141 818 2775 A potential DNA crosslinker. SGTC_1768 st044301 37.178 µM -0.760775401886654 0.206949029188939 no 2678 0.223395614504748 891 3931349 SGTC_1748 st037455 53.6035 µM -0.762178754886172 0.206527087365983 no 2679 0.222976662061164 860 580690 SGTC_916 4466-0038 42 nM -0.763169091466456 0.206229632857335 no 2680 0.222681279728956 869 5722064 YGL116W CDC20 SGTC_2117 5521686 200 µM -0.76557148470886 0.205509113330158 no 2681 0.221965658439294 868 803312 SGTC_1073 triclabendazole 3.09 µM -0.767782715431481 0.204847249619946 no 2682 0.22130814248917 859 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.768671481744959 0.204581582368781 no 2683 0.22104417938082 855 2724 A muscle relaxant with antifungal properties. SGTC_1261 0712-0010 12.7 µM -0.768971699757367 0.204491888480344 no 2684 0.220955055522853 859 2840123 SGTC_2661 dactinomycin 12.96 µM -0.770731204875352 0.203966684999329 no 2685 0.220433135872001 855 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2617 dihydrotanshinone i 20.83 µM -0.770940158637742 0.203904366783607 no 2686 0.22037120116998 858 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2151 5563267 85.4165 µM -0.774404354212591 0.202872862000588 no 2687 0.219345854770993 867 5310824 SGTC_2745 rifampicin 24.3 µM -0.774524685232543 0.202837088137206 no 2688 0.219310288054694 830 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1415 3966-0071 78.1 µM -0.775514176548876 0.202543059813634 no 2689 0.219017945899525 859 2893185 SGTC_2115 tiliquinol 12.7705 µM -0.778212635813705 0.201742505890736 no 2690 0.218221834426899 864 71208 A bioactive hydroxyquinoline. SGTC_629 3448-6466 76.7 µM -0.778263414860627 0.20172745942087 no 2691 0.218206869368225 876 573744 SGTC_2016 5121758 140 µM -0.778295376939874 0.201717988999708 no 2692 0.21819745014868 855 2795203 SGTC_458 nppb 133 µM -0.778753432714826 0.201582295510456 no 2693 0.218062486928938 861 4549 A chloride channel blocker. SGTC_3073 9114972 49.47 µM -0.780105384625567 0.20118211510579 no 2694 0.217664423635115 827 41905075 SGTC_2804 7954240 19.48 µM -0.781075226837328 0.200895333578785 no 2695 0.217379125640612 850 828705 SGTC_61 0978-8327 98.565 µM -0.781762982632887 0.200692113497814 no 2696 0.217176939779858 879 6150059 YHR072W ERG7 SGTC_1074 carmofur 3.8 µM -0.782549196638983 0.200459951931358 no 2697 0.216945942390201 869 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_997 3996-0078 137 µM -0.784106296691504 0.20000063134928 no 2698 0.216488870504345 861 735687 SGTC_2071 5230951 39.92 µM -0.784396353753702 0.199915138943264 no 2699 0.216403788626236 875 1799272 SGTC_606 k015-0008 38.6 µM -0.786408665779523 0.199322628575844 no 2700 0.215814054116229 885 1970475 SGTC_139 0099-0334 718.624 µM -0.786507408278543 0.199293581821324 no 2701 0.215785140322114 891 97690 SGTC_233 rapamycin 362 pM -0.78761436459404 0.19896812663683 no 2702 0.21546115490763 879 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2010 4012422 159 µM -0.789181164865009 0.198508021053791 no 2703 0.215003064443242 881 952393 SGTC_1409 3909-8004 61.9 µM -0.791345910183707 0.197873380365977 no 2704 0.214371082285757 853 2119279 SGTC_2461 5755302 26.15 µM -0.791680131912167 0.197775505573049 no 2705 0.214273604972713 893 2788904 SGTC_3351 9150312 21.596 µM -0.792335315663673 0.197583723910669 no 2706 0.21408259243358 868 4904905 SGTC_3176 9106582 49.47 µM -0.793131693917583 0.19735076402657 no 2707 0.213850549475539 829 17018027 SGTC_3342 9147791 14.508 µM -0.793158891016347 0.197342811152604 no 2708 0.213842627567872 865 1838168 SGTC_3265 9137266 49.47 µM -0.793205537392882 0.197329171444868 no 2709 0.213829040917706 825 17224265 SGTC_2161 5662504 8.5105 µM -0.79349380815494 0.197244891826484 no 2710 0.213745087692718 853 2859334 SGTC_1319 1306-0155 43.7 µM -0.794498492434212 0.19695132986126 no 2711 0.213452643127213 875 3122360 SGTC_884 0851-0618 334 µM -0.797753067991273 0.196002182489793 no 2712 0.212506900634893 873 9642473 SGTC_1491 4138-0063 26.5 µM -0.799258653037776 0.195564041889069 no 2713 0.212070224214178 866 23883227 SGTC_505 gw-5074 63.9 µM -0.801696297850431 0.194855924570034 no 2714 0.211364328936258 878 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3084 9116877 49.47 µM -0.801857950359343 0.194809020941557 no 2715 0.211317566173776 848 27241325 SGTC_1965 Pectolinarigenin 58.4 µM -0.802437745454112 0.194640849338604 no 2716 0.211149893177295 881 5320438 An anti-inflammatory. SGTC_393 acivicin 6.25 µM -0.803896836710293 0.194218025829319 no 2717 0.210728278554692 860 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.804113852582647 0.194155185595898 no 2718 0.210665612515304 869 66535 A nucleotide analog. SGTC_3258 9138477 49.47 µM -0.804119869320921 0.194153443534643 no 2719 0.210663875262875 887 4970355 SGTC_1453 4237-0541 195 µM -0.807556000147575 0.193160116469349 no 2720 0.209673112351971 864 739892 SGTC_2453 5731132 22.18 µM -0.809139263085089 0.192703467986793 no 2721 0.20921752310441 888 1362040 SGTC_2835 9006588 71.43 µM -0.810451069933378 0.192325613680124 no 2722 0.208840488083936 853 2345538 SGTC_2322 7413319 38.22 µM -0.810914620777091 0.19219220039848 no 2723 0.208707351679488 860 1840400 SGTC_2531 methyl deoxycholate 70.07 µM -0.81382044219741 0.191357174458331 no 2724 0.207873911245904 898 16667744 Haematoxylin. SGTC_3257 9139206 32.98 µM -0.814962543390115 0.191029586294245 no 2725 0.207546875430186 865 4910041 SGTC_2738 aclarubicin 5.55 µM -0.815295059573077 0.190934275570331 no 2726 0.207451718015859 846 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3286 9117135 37.221 µM -0.815551323344345 0.19086084135162 no 2727 0.207378399641868 867 3438150 SGTC_1615 st002656 86.5 µM -0.816457209465869 0.190601392116915 no 2728 0.207119343817019 871 1584458 SGTC_2007 4011539 71.82 µM -0.817955333715472 0.190172798986699 no 2729 0.206691346256918 881 45595301 SGTC_3012 9080433 71.4286 µM -0.817995637628289 0.190161276766956 no 2730 0.206679839112736 886 17688859 SGTC_126 0417-1624 672.48 µM -0.818181830480244 0.190108052889265 no 2731 0.206626684236097 894 41912 YDL195W SEC31 SGTC_2831 7999036 19.48 µM -0.818931398896789 0.189893878760316 no 2732 0.206412777182939 891 2988270 SGTC_3006 9075424 71.4286 µM -0.819812799920966 0.18964222597137 no 2733 0.206161416509946 876 7465181 SGTC_3246 9135460 32.98 µM -0.819818375097875 0.18964063483063 no 2734 0.206159827141526 877 41446951 SGTC_996 3970-0799 1.8 µM -0.821519878161949 0.189155414126444 no 2735 0.205675103065102 876 6615648 YGL040C HEM2 SGTC_3248 9135562 49.47 µM -0.823476273239098 0.18859845123856 no 2736 0.205118602222223 884 17650701 SGTC_1440 4100-1550 40 µM -0.823537149319837 0.188581136763579 no 2737 0.205101300255999 877 742806 SGTC_273 hydroxyurea 18.1 mM -0.824911294466104 0.188190560930554 no 2738 0.20471097680281 901 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_648 0375-0473 33.3 µM -0.827052352940973 0.187582999555558 no 2739 0.204103694343315 886 1713139 SGTC_27 0485-0001 32.618 µM -0.827631356108904 0.187418906084758 no 2740 0.203939652401286 859 2054479 SGTC_1022 4477-0945 21.3 µM -0.82844253402183 0.187189161978151 no 2741 0.20370996338939 855 4648966 SGTC_192 3455-0609 60.9 µM -0.829069766768439 0.187011634796272 no 2742 0.203532465137259 862 3769639 SGTC_1837 st055472 66.5 µM -0.829104801450556 0.187001721918905 no 2743 0.203522553524329 876 676091 SGTC_557 1315-0110 16.2 µM -0.829380223053751 0.186923804161314 no 2744 0.203444644412062 877 6833801 SGTC_1954 st077032 68.9 µM -0.833436404694914 0.185778623386534 no 2745 0.20229932517071 892 698907 SGTC_1017 4239-0030 168 µM -0.833844103452142 0.185663759079504 no 2746 0.202184419447997 860 1149593 SGTC_1063 disulfiram 1.84 µM -0.83394169862515 0.185636269330527 no 2747 0.202156919040661 897 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1900 st060200 72.8 µM -0.835031679101691 0.185329424855773 no 2748 0.201849936001676 885 688945 SGTC_783 0848-0141 92.7 µM -0.836127695957344 0.185021198783635 no 2749 0.201541534475238 883 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2299 7976368 114.88 µM -0.837635357139047 0.184597729228579 no 2750 0.201117764440822 886 2979718 SGTC_1400 3771-8998 51.5 µM -0.837712515503469 0.18457607332995 no 2751 0.201096091323803 863 670767 SGTC_3252 9135871 49.47 µM -0.838052470489428 0.184480677595199 no 2752 0.201000617592579 895 17682838 SGTC_2605 digitonin 300 nM -0.839606494491637 0.184044989128403 no 2753 0.20056452832573 874 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_127 0180-0333 59.125 µM -0.841040458565297 0.183643529630553 no 2754 0.200162634621376 833 771601 SGTC_3190 9110366 49.47 µM -0.842055868014147 0.18335958096628 no 2755 0.199878341163598 871 17123768 SGTC_2692 st077426 47.7 µM -0.842930454285027 0.183115231584003 no 2756 0.199633670020575 882 25238571 SGTC_2441 5730946 39.09 µM -0.84344178013187 0.182972467141955 no 2757 0.199490706842439 860 1774275 SGTC_1967 st070177 51.4 µM -0.846124803103863 0.182224494109601 no 2758 0.198741562717276 893 5729214 SGTC_2346 9031566 143.75 µM -0.846672406448475 0.182072068415764 no 2759 0.198588871550241 888 4771086 SGTC_1315 1237-0019 3.69 µM -0.848853526180142 0.181465743904295 no 2760 0.197981400785724 881 825140 SGTC_1480 1070-0044 41.2 µM -0.849123921609827 0.181390665452396 no 2761 0.19790617034234 883 3124987 SGTC_956 1185-0240 191 µM -0.849717719912342 0.181225858672612 no 2762 0.19774102213435 890 1416193 SGTC_2262 9014885 67.46 µM -0.85012637380831 0.181112492615387 no 2763 0.197627415000798 887 6457424 SGTC_1938 st074717 56.4 µM -0.851825442592344 0.180641624698304 no 2764 0.197155491432307 842 17250979 SGTC_195 4234-0266 16.654 µM -0.852582648796166 0.180432025437016 no 2765 0.196945394038147 882 2303354 SGTC_2254 7938975 95.19 µM -0.852624933354552 0.18042032531489 no 2766 0.196933665596242 892 2969277 SGTC_19 0279-0214 38.434 µM -0.855970473074781 0.179496124647282 no 2767 0.196007055963406 899 3566274 YBR002C RER2 SGTC_785 1270-0111 65.3 µM -0.85642375019634 0.179371136779473 no 2768 0.195881716169147 888 6741994 SGTC_2687 chenodiol 100 µM -0.859248471323094 0.178593474032058 no 2769 0.195101723200537 873 5702181 A cholesterol synthesis inhibitor. SGTC_1830 st055982 50.3 µM -0.859428105189573 0.178544091657979 no 2770 0.195052184657003 906 455313 An antimicrobial agent. SGTC_1136 pergolide 1.05886 µM -0.860734442791894 0.178185230726391 no 2771 0.194692159349788 887 47811 A dopamine receptor agonist. SGTC_2800 7887935 81.82 µM -0.861703749570713 0.177919248773218 no 2772 0.194425280863876 910 2961002 SGTC_1006 4099-6547 255 µM -0.863010560984036 0.177561050671222 no 2773 0.194065830200698 913 3146833 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.864883691384699 0.17704841839923 no 2774 0.193551314828582 915 688801 SGTC_1897 st060201 15 µM -0.867274509539829 0.176395466918303 no 2775 0.192895809905358 897 611878 SGTC_955 1216-0110 33 µM -0.869327495883613 0.175835997398352 no 2776 0.192334013861302 898 3619719 SGTC_222 nsc-310342 10.666 µM -0.869859055306871 0.175691322870824 no 2777 0.192188716817352 892 432556 SGTC_1614 st002383 48.6 µM -0.870724000802193 0.175456071910243 no 2778 0.191952435225139 872 1947235 SGTC_2983 9022671 12.99 µM -0.872256402480472 0.175039774342753 no 2779 0.191534257983585 884 6405161 SGTC_652 0437-0092 114 µM -0.873033391036516 0.17482893454831 no 2780 0.191322438901329 886 3091274 SGTC_1772 st048439 82.2 µM -0.873113603360015 0.17480717770949 no 2781 0.191300579961931 889 2927068 YDL195W SEC31 SGTC_338 4055-0136 114 µM -0.87603632283833 0.174015589895457 no 2782 0.190505143883891 898 2900563 SGTC_583 1488-1091 88.9 µM -0.876344908741414 0.173932145865975 no 2783 0.190421279021111 923 4303273 SGTC_664 1222-0054 14.9 µM -0.877455791393912 0.173631965258712 no 2784 0.190119560508979 886 6813991 SGTC_3007 9078383 71.4286 µM -0.879061385682222 0.173198687494997 no 2785 0.189683996567707 891 6496995 SGTC_430 0958-0115 16.4 µM -0.880686981158756 0.172760714405731 no 2786 0.189243632581048 903 6833180 SGTC_2539 epi(13)torulosol 80 µM -0.88075714936861 0.172741825371056 no 2787 0.189224638618918 886 6708597 SGTC_2213 7173844 200 µM -0.881383375660317 0.17257330576703 no 2788 0.189055176256163 902 892728 SGTC_337 1315-0038 354 µM -0.882406774405225 0.172298131445492 no 2789 0.188778436801853 887 1626437 SGTC_713 1488-1073 324 µM -0.882467571899623 0.17228179285896 no 2790 0.188762004280804 901 3312542 SGTC_1418 3966-3099 2.4 µM -0.883591585489849 0.171979905980309 no 2791 0.18845836149673 875 740335 SGTC_722 3534-0461 190 µM -0.883862247668199 0.171907262182167 no 2792 0.18838528942022 890 658262 SGTC_2055 5235184 200 µM -0.885882618194804 0.171365628250169 no 2793 0.187840391747154 882 2836034 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.885901560874631 0.171360555141997 no 2794 0.187835287481271 858 88881 An O-methylated flavonoid and antioxidant. SGTC_1360 1598-0022 39.8 µM -0.889874576952274 0.170298649204004 no 2795 0.186766618170547 901 761525 SGTC_1264 0783-0040 158 µM -0.891581298967491 0.169843774538877 no 2796 0.186308698777176 897 2855798 SGTC_2888 9058547 12.99 µM -0.893602231947297 0.169306164907885 no 2797 0.18576737587782 887 16476514 SGTC_949 1165-0505 146 µM -0.893752333805045 0.169266278360141 no 2798 0.185727208866736 901 6244267 SGTC_1906 st060206 94.7 µM -0.897485531221756 0.168276197387926 no 2799 0.184729945317323 895 5133468 SGTC_1572 epiandrosterone 68.9 µM -0.898683577067825 0.167959254905595 no 2800 0.184410613555262 898 441302 A steroid. SGTC_576 1073-0113 22.7 µM -0.898855858799245 0.16791370947182 no 2801 0.184364721176016 923 5439563 SGTC_1066 ketoconazole 628 nM -0.901184613967172 0.1672988459176 no 2802 0.183745085087307 896 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_17 0960-0276 49.807 µM -0.901197973278464 0.167295322836677 no 2803 0.18374153418334 902 6821114 SGTC_2886 9058944 51.95 µM -0.904305111657897 0.16647721582799 no 2804 0.182916818529424 860 4949929 SGTC_1398 3558-0053 112 µM -0.904744162533333 0.166361822701049 no 2805 0.182800469522843 881 4532369 SGTC_2469 5655019 90.81 µM -0.906275254234421 0.16595981920073 no 2806 0.182395089958838 902 2788239 SGTC_688 0527-0193 473 µM -0.907023773501393 0.165763516616902 no 2807 0.182197112785783 931 4007154 SGTC_3039 9090270 49.47 µM -0.908626670563826 0.165343654704056 no 2808 0.181773611705022 865 17173750 SGTC_14 0354-0009 295 µM -0.910300227533545 0.16490601911704 no 2809 0.181332099295903 918 1713507 SGTC_2868 9035608 32.47 µM -0.910827279995089 0.164768350226045 no 2810 0.181193193165926 903 6462614 SGTC_2628 lathosterol 100 µM -0.911543038493334 0.164581509563172 no 2811 0.18100465978411 905 6710616 SGTC_1668 st014914 51.6 µM -0.913420186875649 0.164092153688103 no 2812 0.180510796274908 906 2839556 SGTC_818 4072-2707 53.5 µM -0.915351349184029 0.163589702843544 no 2813 0.180003605046974 911 882871 SGTC_1801 st050089 28.441 µM -0.916002291914345 0.163420565568046 no 2814 0.179832846404735 904 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_287 k060-0039 29.6 µM -0.916556057418799 0.163276767721696 no 2815 0.179687659919414 901 5861974 SGTC_1177 0983-0204 23.6 µM -0.917687719754721 0.162983161524297 no 2816 0.179391189305537 886 766818 SGTC_2504 purpurogallin 52.29 µM -0.91881826218195 0.162690188820718 no 2817 0.179095319355036 893 5281571 An antioxidant. SGTC_50 0929-0078 56.389 µM -0.918938774007973 0.162658979183124 no 2818 0.17906379878056 876 1377751 SGTC_1167 k781-0610 148 µM -0.919961666505625 0.162394231693727 no 2819 0.178796395807947 891 4525169 SGTC_2164 5685496 200 µM -0.92001856480315 0.162379513378719 no 2820 0.178781528927048 939 759046 SGTC_1701 st028638 40.4 µM -0.920173417059058 0.16233946096609 no 2821 0.178741071727054 912 3490878 SGTC_2827 7993847 71.43 µM -0.920382404855483 0.162285416635861 no 2822 0.178686480040526 865 2985692 SGTC_1512 0259-0544 12.2 µM -0.920583477384495 0.16223343025403 no 2823 0.178633965886806 894 18476 SGTC_191 3914-0123 66.505 µM -0.921639211741914 0.161960652906155 no 2824 0.178358399027582 917 3144412 SGTC_745 0469-0705 296 µM -0.922085341498235 0.161845473147224 no 2825 0.178242031179235 919 3486736 SGTC_490 phenamil 164 µM -0.922850606951469 0.161648024704879 no 2826 0.178042531894158 891 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2746 daunorubicin 9.88 µM -0.925486983601408 0.160969007967099 no 2827 0.177356325659746 861 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1516 st013856 110 µM -0.926466916482409 0.160717094869306 no 2828 0.177101691235624 916 5281404 A mutagen and neurotoxin. SGTC_1850 st056238 17 µM -0.926953115699579 0.160592202373818 no 2829 0.176975438695187 896 5393177 SGTC_452 diindolylmethane 8 µM -0.926986702025518 0.160583577222881 no 2830 0.176966719352293 910 3071 Inhibits expression of several cancer promoting factors. SGTC_2849 9019321 12.99 µM -0.929716606818205 0.159883534696096 no 2831 0.176258916894846 906 16489627 SGTC_2681 menadione 3.18 µM -0.931728748815781 0.159368831319559 no 2832 0.175738362599315 923 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_360 0957-0399 1.01 µM -0.931747101638569 0.159364141689127 no 2833 0.175733619090685 936 6752301 YPR165W RHO1 SGTC_2089 5281248 129.67 µM -0.933027548424382 0.159037176819166 no 2834 0.175402872417894 906 2737878 SGTC_2525 harmine 47.85 µM -0.933144260689808 0.159007395960762 no 2835 0.175372744614384 886 5280953 A monoamine oxidase inhibitor SGTC_88 0180-0332 8.668 µM -0.937256954638704 0.157960314480956 no 2836 0.17431319961942 909 3101745 SGTC_1892 st058411 7.36 µM -0.937809017865787 0.157820106000748 no 2837 0.174171282957613 914 3934738 SGTC_2192 5915882 198.485 µM -0.938194135363066 0.157722345435694 no 2838 0.174072325853677 896 2876149 SGTC_864 0469-0573 172 µM -0.940125120247909 0.157232772377583 no 2839 0.173576692473781 938 689425 SGTC_3076 9116187 49.47 µM -0.942681375559201 0.156586209630043 no 2840 0.172921951239248 900 27241210 SGTC_511 blebbistatin 171 µM -0.943811208550034 0.15630099553209 no 2841 0.17263306592228 927 3476986 A myosin inhibitor. SGTC_3168 9103419 49.47 µM -0.944143277963512 0.156217233315322 no 2842 0.172548218130004 907 16649256 SGTC_3180 9109287 49.47 µM -0.945387324897306 0.155903694038631 no 2843 0.172230585417483 896 18891271 SGTC_3284 9108171 64.8615 µM -0.948531571525254 0.155113094650721 no 2844 0.171429454064031 876 8687505 SGTC_1638 st008370 60.6 µM -0.948984292826653 0.154999479347125 no 2845 0.17131430040909 889 24207134 SGTC_715 0868-0130 184 µM -0.949337231134579 0.154910943795685 no 2846 0.171224561749233 952 2876258 SGTC_1024 4507-0395 26 µM -0.94946060381761 0.15488000329689 no 2847 0.17119319990406 908 4201836 SGTC_662 k832-1615 104 µM -0.954179682323649 0.153699575071599 no 2848 0.169996348670724 918 5878478 SGTC_3149 9097855 49.47 µM -0.955203595928055 0.1534442422174 no 2849 0.169737373852158 879 25236625 YMR079W SEC14 SGTC_3341 9147222 25.867 µM -0.956075988049451 0.153226915998139 no 2850 0.169516922562619 918 1939759 SGTC_442 cape 100 µM -0.958352300884885 0.152660812529429 no 2851 0.168942569542446 919 5281787 SGTC_2523 spermine 47.74 µM -0.959431296596657 0.152392958973024 no 2852 0.168670757525546 893 1103 A DNA binding polyamine. SGTC_2200 6600604 21.907 µM -0.96052000376303 0.152123010947471 no 2853 0.168396784124877 950 2904777 SGTC_1759 st043059 70 µM -0.961806122986147 0.151804523418945 no 2854 0.168073500881533 937 669426 SGTC_2871 9038510 12.99 µM -0.962624503227013 0.151602095039831 no 2855 0.167867998138679 913 4945164 SGTC_989 1501-0895 10.3 µM -0.964191830806852 0.151214913784611 no 2856 0.167474879643509 909 2830112 SGTC_2861 9024595 19.48 µM -0.964231120503198 0.151205216401547 no 2857 0.167465032593815 891 16482810 SGTC_769 0302-0231 76 µM -0.964265513399639 0.151196727973782 no 2858 0.167456413119464 925 571869 YER009W NTF2 SGTC_2591 skatole 100 µM -0.967801986071349 0.150325591771081 no 2859 0.166571635869712 928 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2716 st080858 38.6235 µM -0.968402087127887 0.150178101989491 no 2860 0.166421798761644 898 5296050 SGTC_986 1493-0483 84 µM -0.974230374379545 0.148750673704376 no 2861 0.164971083161515 925 40079 SGTC_284 0988-0104 32.6 µM -0.974391309403256 0.148711387572021 no 2862 0.164931141442679 932 4666532 SGTC_2476 5806916 10.51 µM -0.977327418058673 0.147995866393232 no 2863 0.1642035416965 901 2870194 SGTC_78 0336-0123 156.75 µM -0.979029788644444 0.147582060694435 no 2864 0.163782630535481 907 6765896 SGTC_502 l-744,832 89.3 µM -0.981069846851083 0.147087193031488 no 2865 0.163279149394098 934 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1776 st049249 45.9 µM -0.984487378136925 0.146260680207593 no 2866 0.162437967203024 936 1822314 SGTC_3157 9099274 49.47 µM -0.984585624474977 0.146236966033286 no 2867 0.162413826885141 900 17217662 SGTC_761 k216-0224 480 µM -0.986213076578217 0.145844516031361 no 2868 0.162014281858004 948 1340404 SGTC_3297 9117502 71.43 µM -0.987352448151446 0.145570185250853 no 2869 0.161734943585636 923 7453720 SGTC_2351 9026858 72.31 µM -0.989414895791251 0.145074485007078 no 2870 0.161230094748372 967 1409300 SGTC_1704 st028805 70.8 µM -0.989764813892268 0.144990496588363 no 2871 0.161144543417549 926 2876101 SGTC_1903 st060211 78.3 µM -0.994200840327171 0.143928585676951 no 2872 0.160062549544593 913 688960 SGTC_404 fumagillin 50 µM -0.995477955845042 0.143623840498023 no 2873 0.159751930239059 920 12015870 A methionine aminopeptidase binder. SGTC_1424 4048-1941 275 µM -0.99614028629902 0.143465966881268 no 2874 0.159590994013749 922 X1424 SGTC_2951 9072950 58.06 µM -1.00082250098288 0.142353252597967 no 2875 0.158456314620251 926 16488155 SGTC_620 0109-0052 432 µM -1.00381098154852 0.1416461095799 no 2876 0.157734865101415 939 493037 SGTC_2876 9059903 25.97 µM -1.00511668779166 0.141337897780512 no 2877 0.157420332722111 898 6916095 SGTC_3237 9133362 49.47 µM -1.00674420991551 0.140954358258888 no 2878 0.157028855472897 945 43845137 SGTC_2424 5537928 59.2 µM -1.00738622455186 0.140803256364287 no 2879 0.156874604280562 923 5382802 SGTC_1291 0993-0025 5.79 µM -1.00828283180364 0.140592418589151 no 2880 0.156659351261509 936 4353356 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.0119890546219 0.139723172309411 no 2881 0.155771643407826 926 688803 SGTC_98 0074-0023 107.663 µM -1.01403656476568 0.139244525597935 no 2882 0.155282652564002 939 3563821 SGTC_873 0591-4978 488 µM -1.01415868765339 0.139216012216664 no 2883 0.155253518960043 924 3305145 SGTC_885 0865-0106 16.8 µM -1.01423463088507 0.139198282914261 no 2884 0.15523540378215 925 2793380 SGTC_428 3448-4153 16.5 µM -1.01462258646064 0.139107736846428 no 2885 0.155142884266427 915 3834874 SGTC_2634 4'-methoxyflavone 100 µM -1.01462986264822 0.139106039019158 no 2886 0.155141149391505 949 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2839 9003951 25.97 µM -1.02053513067038 0.137732751767592 no 2887 0.153737368424224 917 2990634 SGTC_1677 st019204 53.9 µM -1.02429690748819 0.136862779273334 no 2888 0.152847529094364 942 3945625 SGTC_2866 9034245 58.44 µM -1.02557920561447 0.136567087043195 no 2889 0.152544986638188 920 6462273 SGTC_253 dyclonine 31.25 µM -1.03115772283282 0.135285792508346 no 2890 0.151233431315882 939 3180 An oral anasthetic. SGTC_987 1497-1013 404 µM -1.03165840052806 0.135171199323049 no 2891 0.151116085796042 944 1676435 SGTC_1108 betulinic acid 729.144 nM -1.03168116614697 0.135165990398079 no 2892 0.151110751581474 921 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_315 k915-0449 187 µM -1.03173657954525 0.135153312019349 no 2893 0.15109776818589 919 20970215 YNL149C PGA2 SGTC_3215 9129942 49.47 µM -1.03257087060254 0.134962527891345 no 2894 0.150902382956785 957 17682944 SGTC_303 1348-1668 34.2 µM -1.03488560327855 0.134434166700952 no 2895 0.150361169406585 935 5380509 SGTC_1775 st081588 35.1725 µM -1.03504487610672 0.134397863357643 no 2896 0.150323977038716 924 1426443 YGL099W LSG1 SGTC_553 k007-0256 45.7 µM -1.03505299395297 0.134396013222594 no 2897 0.150322081575602 940 6287000 SGTC_2289 7946404 165.07 µM -1.03524105585263 0.134353157006495 no 2898 0.150278174830841 922 1246120 YPR165W RHO1 SGTC_959 1222-0044 107 µM -1.03620403269207 0.134133857470262 no 2899 0.150053482907056 917 6083612 SGTC_225 nsc-122657 1.016 µM -1.03741566717328 0.133858280431861 no 2900 0.149771089918599 943 275685 SGTC_2906 7926292 26.41 µM -1.03882940070939 0.133537229719985 no 2901 0.149442042569928 950 2966319 SGTC_2616 abietic acid 100 µM -1.04088293910364 0.133071826959417 no 2902 0.148964940388757 948 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2664 lyso-paf C-16 73.48 µM -1.04218882683607 0.132776449066135 no 2903 0.148662071101183 938 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1803 st050068 52.4 µM -1.05509191592057 0.129882174529166 no 2904 0.145691644466945 948 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1379 2144-0755 36.5 µM -1.05551596618029 0.129787803528483 no 2905 0.145594705628424 947 5392327 SGTC_3314 9135860 59.4275 µM -1.05678259086555 0.129506203111793 no 2906 0.145305410683449 920 25252478 SGTC_619 1652-1634 108 µM -1.05910945060317 0.128989991275739 no 2907 0.144774968223832 962 5400454 SGTC_2463 5473429 200 µM -1.06010103272081 0.12877044381445 no 2908 0.144549319018653 928 5399405 SGTC_2212 7123476 200 µM -1.06012693177556 0.128764712947804 no 2909 0.144543428481971 931 1085715 SGTC_1624 st003710 6.25 µM -1.06163886048481 0.128430464447759 no 2910 0.144199832455806 954 24207033 SGTC_1935 st074532 41.6 µM -1.06457281205976 0.127783562902904 no 2911 0.143534644289346 926 2829742 SGTC_282 k297-0036 65.7 µM -1.06661328709146 0.127334999667653 no 2912 0.143073249000532 964 5061378 SGTC_2972 9093619 59.92 µM -1.07452848388626 0.125605350234112 no 2913 0.141292942760705 927 25236256 SGTC_1952 st077036 64.1 µM -1.07688467863143 0.125093649567708 no 2914 0.140765894363696 943 2937007 SGTC_718 1130-0073 349 µM -1.07716513740421 0.125032838740376 no 2915 0.140703248548807 955 6740020 SGTC_1096 rimcazole 32.2 µM -1.07788958435466 0.124875855179337 no 2916 0.140541517073459 926 18528119 A dopamine reuptake inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.07906129884766 0.124622242852006 no 2917 0.140280201134108 945 1377 SGTC_2854 9024559 71.43 µM -1.07972007423124 0.124479812105207 no 2918 0.140133425961971 961 3163529 SGTC_95 0471-0001 561.058 µM -1.08039256183933 0.124334534136616 no 2919 0.139983703349858 942 4015405 SGTC_2650 prasterone 100 µM -1.08330345359467 0.123707059818117 no 2920 0.139336876441315 927 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_625 k213-0058 121 µM -1.0840633614081 0.123543619026323 no 2921 0.139168353189211 956 3655420 SGTC_2015 5119600 184 µM -1.08447872820841 0.123454345986348 no 2922 0.13907629677337 956 2828786 SGTC_2400 5203494 178.7 µM -1.08459873095587 0.12342856271578 no 2923 0.139049708667262 941 6777674 SGTC_638 3970-0837 4.09 µM -1.0868611683992 0.122943171039067 no 2924 0.13854908494329 928 4118451 YLR208W SEC13 SGTC_2779 methotrexate 400 µM -1.0870187399886 0.122909414969935 no 2925 0.138514263892004 936 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_281 1672-3440 14.9 µM -1.08992356257085 0.122288287836409 no 2926 0.137873408135747 949 6833000 SGTC_2963 9082507 9 µM -1.09252803966028 0.121733258730807 no 2927 0.137300536398841 965 16459611 SGTC_2189 6047310 154.431 µM -1.09524925463045 0.121155245493742 no 2928 0.136703726233966 945 711535 SGTC_1166 k206-0078 225 µM -1.09852716746565 0.120461550779363 no 2929 0.135987180659665 943 5404595 SGTC_2576 guaiol 23.12 µM -1.0998973691102 0.120172409786486 no 2930 0.135688420571227 921 227829 SGTC_1103 duloxetine 36.1 µM -1.10025941225342 0.120096092912099 no 2931 0.135609555485259 973 60835 A selective serotonin reuptake inhibitor. SGTC_39 0986-0283 58.349 µM -1.10036876269671 0.120073049105884 no 2932 0.135585741483369 913 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2967 9089538 49.85 µM -1.10304736280837 0.119509551050323 no 2933 0.135003298793813 962 728216 SGTC_3292 9120825 59.784 µM -1.1073289865325 0.118612703387421 no 2934 0.134075858168449 937 24824900 SGTC_435 c-PAF 6.7 µM -1.10998620831515 0.118058507362362 no 2935 0.133502484796559 941 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2773 thioridazine 9.09 µM -1.11391537935338 0.117242391224477 no 2936 0.13265774547396 964 5452 An antipsychotic. SGTC_3291 9121177 71.43 µM -1.11693368714561 0.116618187484165 no 2937 0.132011339832666 961 17015612 SGTC_1854 st056233 32.9 µM -1.11986464618741 0.116014306827893 no 2938 0.131385722950112 977 5393174 SGTC_919 tnp00227 403.569 nM -1.12109341563398 0.115761798648937 no 2939 0.131124050547115 971 1269246 A methoxyflavone. YNL221C POP1 SGTC_1591 genipin 88.4 µM -1.12115179913703 0.115749810747484 no 2940 0.131111626462651 973 442424 A DNA cross-linking agent. SGTC_3133 9127736 49.47 µM -1.12154918174378 0.115668239486291 no 2941 0.131027084537341 931 27243420 SGTC_3126 9127922 49.47 µM -1.12362186962319 0.115243437984468 no 2942 0.130586737155964 956 45595682 SGTC_831 k061-1017 217 µM -1.12405070900322 0.115155685145466 no 2943 0.130495757137096 988 1240153 SGTC_2316 5844804 197.44 µM -1.1274858508002 0.114454470751794 no 2944 0.12976855973376 949 776813 SGTC_596 1155-0152 116 µM -1.12786804638927 0.114376641601186 no 2945 0.129687825208258 954 280313 SGTC_3139 9095020 49.47 µM -1.13001297826472 0.113940553273332 no 2946 0.129235377927204 895 25236292 SGTC_1091 telmisartan 47.6 µM -1.13181169939495 0.113575767756579 no 2947 0.128856804006269 981 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1762 st045503 25.4615 µM -1.13454445056473 0.113023153201989 no 2948 0.128283119608395 989 4645554 SGTC_2061 5245884 80.95 µM -1.13637831090132 0.112653389152531 no 2949 0.127899134515468 967 573863 SGTC_2829 7992743 58.44 µM -1.13686314337336 0.112555776197566 no 2950 0.127797750895051 966 16462845 SGTC_1281 0884-0031 11.8 µM -1.13815135622801 0.112296709518399 no 2951 0.127528643303487 969 1548255 SGTC_3322 9139058 2.11 µM -1.13997703514336 0.111930285753115 no 2952 0.127147934383954 961 4908926 YPR165W RHO1 SGTC_3330 9141424 71.43 µM -1.14156136786385 0.11161299505922 no 2953 0.126818194895458 953 27261020 SGTC_574 1315-0397 40 µM -1.14451541838628 0.111023113686042 no 2954 0.126204973670289 974 6794277 SGTC_1187 1391-0724 117 µM -1.14537337277171 0.110852211714477 no 2955 0.12602726179226 974 6997986 SGTC_766 1391-0721 126 µM -1.14707401606454 0.110514005860256 no 2956 0.125675515909185 991 1020919 YIL115C NUP159 SGTC_2274 7947094 46.08 µM -1.1474533412649 0.110438670698277 no 2957 0.125597153183226 966 2971028 SGTC_213 1246-0773 967 nM -1.14813264354161 0.110303851179519 no 2958 0.125456905040188 960 6251622 SGTC_2185 6113692 200 µM -1.14889788587106 0.110152116757806 no 2959 0.125299044754799 970 874150 SGTC_1182 1222-0449 220 µM -1.14926140514496 0.110080089603233 no 2960 0.125224103707281 957 658318 SGTC_1090 efavirenz 20.7 µM -1.1494625533141 0.110040248935627 no 2961 0.125182649607569 948 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1502 4534-4282 27.7 µM -1.15010097494675 0.109913867671276 no 2962 0.125051142440706 987 3278949 SGTC_2890 9046729 58.44 µM -1.15146526495954 0.109644143486782 no 2963 0.124770438637437 958 903329 SGTC_2959 9079155 11 µM -1.15218985876718 0.10950108251421 no 2964 0.124621532026033 963 16189457 SGTC_138 0850-0259 40.9225 µM -1.15231344661811 0.109476695199335 no 2965 0.124596146687655 947 6813004 SGTC_2482 5981709 142.65 µM -1.15240988530062 0.109457667878951 no 2966 0.124576340385963 974 877755 SGTC_2083 5306046 65.942 µM -1.15650762374411 0.10865137876494 no 2967 0.123736791511779 949 539837 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.15909411571947 0.108144653333529 no 2968 0.123208912073172 962 165521 SGTC_1198 1612-1005 86.7 µM -1.16257235360366 0.107465909256213 no 2969 0.122501526535623 979 6998509 SGTC_1071 trifluoperazine 6.31 µM -1.167163307545 0.106574737707106 no 2970 0.121572212831933 996 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2921 7974240 10.71 µM -1.16852338484795 0.106311753920959 no 2971 0.121297856080583 964 2979074 YDR527W RBA50 SGTC_2845 9003024 42.97 µM -1.17027219795494 0.10597429356066 no 2972 0.120945723227262 952 2990173 SGTC_144 4161-2749 112.381 µM -1.17141548473041 0.105754097654983 no 2973 0.120715905531826 958 797501 YMR168C CEP3 SGTC_2178 5812956 200 µM -1.17163509164064 0.105711839475471 no 2974 0.120671796485497 953 5403383 SGTC_3251 9135047 49.47 µM -1.17200500444065 0.105640686068925 no 2975 0.120597523473269 962 17682963 SGTC_484 loperamide 105 µM -1.17658987760134 0.104761650389263 no 2976 0.1196796199606 955 3955 An opioid-receptor agonist. SGTC_1861 st057647 17.4 µM -1.17672323654744 0.104736161634564 no 2977 0.119652995097661 969 688668 SGTC_2847 9005661 71.43 µM -1.17831868197181 0.104431574037495 no 2978 0.11933479133451 954 2991449 SGTC_540 1187-0821 17.3 µM -1.17866279029962 0.10436596430522 no 2979 0.11926623897845 959 847520 SGTC_2960 9079389 5.97 µM -1.17980851477124 0.104147728998897 no 2980 0.119038191107264 974 16457355 SGTC_1933 st074711 15.9 µM -1.18203105725847 0.103725327259544 no 2981 0.118596688969722 957 17250958 SGTC_3052 9092717 49.47 µM -1.18219596381957 0.103694035810652 no 2982 0.118563976893652 973 25237534 SGTC_224 benfluorex 43.875 µM -1.182358646251 0.103663173107655 no 2983 0.118531712260509 983 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3244 9134489 49.47 µM -1.18306338475953 0.103529553189032 no 2984 0.118392013886634 981 16584271 SGTC_3199 9111318 49.47 µM -1.1843872886135 0.103278876255766 no 2985 0.118129894840334 942 8548020 SGTC_1257 0669-0121 16 µM -1.18744725168004 0.102701169147477 no 2986 0.117525625597648 961 4307855 SGTC_811 0416-0114 265 µM -1.18908269199314 0.102393370231801 no 2987 0.117203564251695 948 6612453 SGTC_1377 2944-0135 198 µM -1.18964028355368 0.102288581911429 no 2988 0.117093902809448 941 1894137 SGTC_1437 4092-1038 11.6 µM -1.1904980601868 0.102127532056154 no 2989 0.116925345991093 977 3977136 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.19587725782423 0.101121777736146 no 2990 0.115872230602612 974 16486 A toxic proline analog. SGTC_3269 9137823 49.47 µM -1.19746576384136 0.100826158269673 no 2991 0.115562532053722 926 17682936 SGTC_816 0325-0417 81.3 µM -1.20332281009877 0.0997416131081672 no 2992 0.114425712725626 960 68101 SGTC_2129 girgensonine 121.053 µM -1.20429806623816 0.0995618564488629 no 2993 0.114237196921926 981 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3081 9117243 49.47 µM -1.20503811916918 0.0994256099017829 no 2994 0.114094293278299 977 45595589 SGTC_2377 9073351 62.6 µM -1.20759593103864 0.0989557566471071 no 2995 0.113601362555807 993 7337946 YHR072W ERG7 SGTC_2093 5331342 194.4 µM -1.20942063058212 0.0986215654334431 no 2996 0.113250643315915 977 33839 SGTC_1807 st050092 58.9 µM -1.20946097469908 0.0986141858103438 no 2997 0.113242897649435 982 5008496 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.21005121718786 0.0985062666632593 no 2998 0.113129620210877 942 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2124 5246320 200 µM -1.21040403504326 0.0984417992232361 no 2999 0.113061947165736 966 579342 SGTC_3355 9151058 44.0485 µM -1.21095602021669 0.0983410015970195 no 3000 0.112956130334282 974 17015728 SGTC_1125 tnp00248 1.32998 µM -1.21107596786928 0.0983191080407928 no 3001 0.112933145444884 967 24207736 SGTC_2423 st077119 87.2 µM -1.21454943585351 0.097686657670976 no 3002 0.112268992028493 958 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2899 9053889 58.44 µM -1.21547597929183 0.0975184573528299 no 3003 0.112092302436936 961 6470052 SGTC_3001 9076041 71.4286 µM -1.21792660849127 0.097074605732006 no 3004 0.111625931810186 970 16004211 SGTC_549 1661-1316 519 µM -1.22177962945618 0.0963797577240022 no 3005 0.110895486955478 984 2857282 SGTC_520 3584-0023 682 µM -1.22416809255517 0.0959508649615742 no 3006 0.110444411588875 970 1340790 SGTC_3319 9138450 16.7555 µM -1.22498953704642 0.0958036842518863 no 3007 0.110289581361525 947 2029690 SGTC_2220 6782180 200 µM -1.22519502620843 0.0957668921150863 no 3008 0.110250874022872 965 833803 SGTC_856 0433-0016 11.3 µM -1.2267618370549 0.0954867016784533 no 3009 0.109956059186694 984 3911780 SGTC_1086 cerivastatin 2.18 µM -1.22793603988 0.0952771166001302 no 3010 0.109735489532485 948 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_380 3970-0968 6 µM -1.22831830132894 0.0952089593623761 no 3011 0.109663751711913 980 2891601 SGTC_3000 9075062 71.4286 µM -1.22985510404218 0.0949353096558993 no 3012 0.109375684498545 935 17057871 SGTC_3318 9139014 38.6185 µM -1.23089131225213 0.0947511253074792 no 3013 0.10918175867141 979 16643984 SGTC_468 gf-109203x 121 µM -1.2311476912216 0.0947055950218934 no 3014 0.109133815630397 1002 2396 A protein kinase C inhibitor. SGTC_2421 5690543 90.72 µM -1.23141814036435 0.0946575834958313 no 3015 0.109083257856112 990 3397993 SGTC_532 1548-0774 215 µM -1.23480548874956 0.0940577627494161 no 3016 0.10845145206832 1003 5932993 SGTC_1809 st050081 57.6 µM -1.24031645594584 0.0930878988271848 no 3017 0.107429184054557 985 5036894 SGTC_2976 9009005 19.48 µM -1.24150231992099 0.0928801708487466 no 3018 0.107210120843144 960 2993148 SGTC_117 lucigenin 22.078 µM -1.2435215415924 0.0925272524353873 no 3019 0.106837853963626 1010 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_931 2812-0076 566 µM -1.24640113138074 0.0920256769886817 no 3020 0.106308583052286 991 3450959 SGTC_2241 6772625 37.8075 µM -1.2472066827137 0.0918857247193616 no 3021 0.106160861600319 964 2285411 SGTC_871 0574-0004 149 µM -1.2499397015817 0.0914120789995527 no 3022 0.10566078753287 996 9551173 SGTC_1235 benzylparaben 21.5 µM -1.25208054121567 0.0910423267735961 no 3023 0.105270258702408 1001 7180 SGTC_2966 9084041 48.03 µM -1.25340254493216 0.0908145533850203 no 3024 0.105029622886549 989 17741380 SGTC_378 3970-0959 8.33 µM -1.25396628741676 0.0907175526082208 no 3025 0.10492712965873 1005 6615653 SGTC_716 1683-5115 658 µM -1.2541795445736 0.0906808784067932 no 3026 0.104888376557856 982 723597 SGTC_22 0964-0034 14.468 µM -1.2556358200842 0.0904307342842241 no 3027 0.104624019070172 997 138402 SGTC_2125 5246583 200 µM -1.25915922755 0.0898276393842603 no 3028 0.103986412564172 1002 835267 SGTC_196 k015-0023 18.111 µM -1.25919065933253 0.0898222727531996 no 3029 0.103980737282131 971 5211998 SGTC_1482 3346-2049 8.48 µM -1.26256431632053 0.0892476425314449 no 3030 0.103372899329309 981 3826804 SGTC_2096 5468907 200 µM -1.26277834770486 0.0892112793499144 no 3031 0.103334424098385 989 759785 SGTC_1265 0819-1001 68.8 µM -1.27079706439786 0.0878568587835454 no 3032 0.101900426687522 979 3106768 SGTC_893 0958-0369 48.9 µM -1.2732023549595 0.0874535928458264 no 3033 0.101473122571194 996 6819948 SGTC_2819 7996655 46.38 µM -1.27522288474625 0.0871159041334329 no 3034 0.101115181739101 962 6456960 SGTC_3308 9128332 17.569 µM -1.27572181756418 0.0870326682059903 no 3035 0.101026936648181 981 17332805 YDL196W YDL196W SGTC_2466 5983409 37.09 µM -1.27595376347021 0.0869939933836223 no 3036 0.100985932033434 1010 2879657 SGTC_2606 farnesol 9.78 µM -1.27846153290236 0.0865766655558972 no 3037 0.100543369882583 975 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2748 diazoxide 86.69 µM -1.27906002088706 0.0864772903562299 no 3038 0.100437960319521 950 3019 A potassium channel activatior. SGTC_2820 7989630 71.43 µM -1.27967369133099 0.086375482781121 no 3039 0.100329960479232 963 2984098 SGTC_2543 pimpinellin 60.67 µM -1.28434759924505 0.0856030231291306 no 3040 0.0995101794898883 979 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_443 clozapine 122 µM -1.28506394426998 0.0854850909215801 no 3041 0.0993849699128073 1007 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2063 5246145 200 µM -1.28593741820444 0.0853414552016946 no 3042 0.0992324517368449 993 711240 SGTC_2378 9074213 121.43 µM -1.28596496300555 0.0853369286243769 no 3043 0.0992276448961645 983 657714 SGTC_795 0685-0265 78 µM -1.2859840080012 0.0853337989685108 no 3044 0.0992243214553052 982 302754 SGTC_1908 st060353 56.5 µM -1.28963024282342 0.0847361975508705 no 3045 0.0985895350364743 992 4227716 SGTC_219 mitoxanthrone 164.414 µM -1.29039079710337 0.0846119426768318 no 3046 0.0984575028941796 1009 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_217 ketoconazole 989 nM -1.29089547788881 0.0845295663690475 no 3047 0.0983699618516354 930 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1162 k048-0130 20.1 µM -1.29490409306521 0.0838773974261505 no 3048 0.0976766581764601 982 6797406 SGTC_2508 celastrol 40.54 µM -1.29622527484691 0.0836632820234849 no 3049 0.0974489421180049 944 122724 Celastrol is a natural product and antioxidant. SGTC_697 0508-1955 564 µM -1.29735901112878 0.0834798723084266 no 3050 0.0972538444150627 999 6243113 SGTC_1805 st050013 60.3 µM -1.29831386158862 0.0833256363297032 no 3051 0.0970897525331194 975 4037144 SGTC_366 0181-0206 4.31 µM -1.30264375526128 0.0826289205082304 no 3052 0.0963482061550411 1013 274874 SGTC_3217 9129673 49.47 µM -1.30904654942128 0.0816067061478449 no 3053 0.0952592916064674 999 17248312 SGTC_1448 4255-0083 152 µM -1.31076040105719 0.0813347119663875 no 3054 0.0949693624710613 1008 5399660 SGTC_2309 7664088 163.95 µM -1.31570967259726 0.0805530845132872 no 3055 0.0941357532301637 975 704922 SGTC_2305 7443522 69.23 µM -1.31597507046322 0.0805113316633529 no 3056 0.0940912050645739 973 5415886 SGTC_3328 9140624 29.0385 µM -1.32093921563828 0.0797333734927079 no 3057 0.093260816287413 1006 4904392 SGTC_2302 7771753 200 µM -1.32194146818131 0.0795769972754136 no 3058 0.0930938211828064 979 2203047 SGTC_3213 9129884 49.47 µM -1.32421671510511 0.0792228639096316 no 3059 0.0927155405440436 992 17190742 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.32568476809142 0.0789950012764432 no 3060 0.0924720674101026 1010 94937 An inhibitor of serotonin biosynthesis. SGTC_3116 9124943 49.47 µM -1.32622515438892 0.0789112507704759 no 3061 0.0923825648306145 973 41905195 YPL160W CDC60 SGTC_3336 9143619 71.43 µM -1.32859469210166 0.0785448074659343 no 3062 0.0919908620850168 1016 45595730 SGTC_2646 retinol 96.75 µM -1.32871915404372 0.0785255954416004 no 3063 0.0919703216200659 975 445354 A vitamin A analog and teratogen. SGTC_1381 2324-0066 62.1 µM -1.32908354065139 0.0784693689747087 no 3064 0.0919102049311655 1003 10885928 SGTC_3271 9137798 49.47 µM -1.33074488066436 0.078213403597672 no 3065 0.0916364849974907 943 6498326 SGTC_3242 9133940 49.47 µM -1.33329609977233 0.0778215667078611 no 3066 0.0912173265565725 1009 17248444 SGTC_1633 st005664 67.9 µM -1.33515895714944 0.0775363964083051 no 3067 0.0909121633176779 1022 2063822 SGTC_2267 7931562 200 µM -1.33544379585369 0.0774928627037927 no 3068 0.0908655694165042 1005 934880 SGTC_3175 9106517 49.47 µM -1.34596085978368 0.075898436422018 no 3069 0.0891575698348182 1012 41468073 SGTC_1420 4'-methoxyflavone 42 µM -1.34715662988242 0.0757187465000313 no 3070 0.088964896347728 995 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1617 st002906 78 µM -1.3473827625274 0.0756848017205062 no 3071 0.0889284946504102 1006 5150859 SGTC_3119 9125183 49.47 µM -1.34741874015075 0.0756794021872371 no 3072 0.0889227041758746 982 22695334 SGTC_3224 9130643 49.47 µM -1.34787675779489 0.0756106883978222 no 3073 0.0888490123447137 997 17644395 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.3503653134264 0.0752381750095647 no 3074 0.0884494157010332 1004 676296 Flavone; oxidizing agent. SGTC_2785 7756463 72.73 µM -1.35052745807484 0.0752139521189279 no 3075 0.0884234260719824 992 2201551 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.35076793439516 0.0751780381595171 no 3076 0.0883848913966627 1002 641818 YHR062C RPP1 SGTC_1153 4055-0057 267 µM -1.36240464371906 0.0734557327719799 no 3077 0.0865351095222619 990 882706 SGTC_3111 9122088 49.47 µM -1.36388302429728 0.0732391012182491 no 3078 0.0863021921995091 987 16876704 SGTC_1192 1488-0095 21.4 µM -1.36890746896986 0.0725065066659709 no 3079 0.0855141003781021 1022 915875 SGTC_2446 5162541 200 µM -1.37058816687613 0.0722627076974696 no 3080 0.0852516868964219 1015 1549321 SGTC_2596 sinensetin 100 µM -1.37337154665865 0.0718603380786898 no 3081 0.0848184353034915 993 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_611 3453-1652 23.7 µM -1.37394414522087 0.0717777758567174 no 3082 0.0847295116281154 1009 1560575 SGTC_2268 7933382 153.85 µM -1.38140907047028 0.0707080646355731 no 3083 0.0835766092714428 990 935025 YOR257W CDC31 SGTC_2187 6125751 200 µM -1.38282984171519 0.0705058653382212 no 3084 0.0833585232494463 1022 874498 SGTC_501 nsc-95397 161 µM -1.38604590786511 0.0700498079012365 no 3085 0.0828664429337972 998 262093 SGTC_2283 7944793 200 µM -1.38622678867594 0.0700242254879156 no 3086 0.0828388319739248 977 2970533 SGTC_2977 9011197 71.43 µM -1.38636656259294 0.0700044618464205 no 3087 0.0828175006100985 983 2704722 SGTC_491 tetrandrine 80.3 µM -1.38655451677347 0.0699778924163259 no 3088 0.0827888228111774 1014 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_318 1488-0629 67.2 µM -1.38740699843133 0.0698574819724282 no 3089 0.082658846088642 1015 3662576 SGTC_2667 digitoxin 100 µM -1.39486505304246 0.0688108440446921 no 3090 0.0815282686413326 969 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2269 7935389 174.42 µM -1.39912983283534 0.0682177966618291 no 3091 0.0808870265343857 988 97605 SGTC_1158 4092-0494 91.8 µM -1.40294398359597 0.0676907610482346 no 3092 0.0803167718048227 1014 1148199 SGTC_232 clozapine 119 µM -1.40529974813025 0.0673668186161056 no 3093 0.0799660816158747 1016 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3230 9131665 49.47 µM -1.40548411040692 0.0673415175074186 no 3094 0.0799386855082013 987 15943720 SGTC_865 0488-0499 301 µM -1.41168443544268 0.0664948811858285 no 3095 0.0790214491313259 990 9634651 SGTC_580 1123-0028 41 µM -1.4129897670848 0.0663176964528975 no 3096 0.0788293664496665 1031 1677248 YPR107C YTH1 SGTC_2891 9063876 19.48 µM -1.41376291432786 0.0662129225690875 no 3097 0.0787157629100405 1006 6472478 SGTC_2292 7671323 168.05 µM -1.41539305572471 0.0659924323800197 no 3098 0.0784766422743705 1013 937504 SGTC_1186 1319-0216 26 µM -1.41877589944347 0.0655366903131663 no 3099 0.0779821805670753 1008 4565136 SGTC_1696 st025591 34.7925 µM -1.42152539229424 0.0651680754011729 no 3100 0.0775820385149597 993 2787147 SGTC_26 0302-0163 425.158 µM -1.42182861789332 0.0651275216958493 no 3101 0.077538004790858 1040 3100915 SGTC_749 1000-0129 128 µM -1.42247443320917 0.0650412149621587 no 3102 0.077444284231887 1019 708470 SGTC_932 2857-0803 154 µM -1.42279930588674 0.0649978325623345 no 3103 0.077397171325509 1017 674898 SGTC_118 0083-0097 135.343 µM -1.42684115725948 0.0644599735444919 no 3104 0.0768128424610567 1034 5207356 SGTC_1064 honokiol 6.76 µM -1.43139266568137 0.063858439758211 no 3105 0.0761588546122225 1029 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3010 9080089 71.4286 µM -1.43163612748449 0.063826386932815 no 3106 0.076123992354627 1008 17027233 SGTC_1327 1436-0082 2.18 µM -1.43170521592228 0.0638172934135456 no 3107 0.0761141015212975 1016 15992205 SGTC_506 n9-isopropylolomoucine 153 µM -1.43322602952884 0.0636173768795526 no 3108 0.0758966266246545 1002 6610355 SGTC_860 0443-0016 25.1 µM -1.43735493421482 0.0630770743113732 no 3109 0.0753085835051609 1011 5337942 SGTC_2717 st081029 62.2815 µM -1.44969479987411 0.0614835850852674 no 3110 0.0735718232527857 1002 5292846 SGTC_926 2268-1401 59.4 µM -1.44989192415489 0.0614583872938106 no 3111 0.0735443298667203 1019 2931578 SGTC_1052 3253-3998 198 µM -1.45012412763326 0.0614287157839094 no 3112 0.0735119539808998 1009 5450317 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.45614026671294 0.0606638532116892 no 3113 0.0726769240783957 1019 551469 SGTC_2027 5150920 200 µM -1.45632955555441 0.0606399093796388 no 3114 0.0726507694669612 977 786715 SGTC_3101 9120531 49.47 µM -1.45704647679686 0.0605492904262549 no 3115 0.0725517756400267 1017 24824904 SGTC_2647 atorvastatin 60.16 µM -1.45760617509994 0.0604786181448019 no 3116 0.0724745632941162 999 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_254 nsc-64875 3.808 µM -1.45776860038666 0.0604581210301867 no 3117 0.0724521679445228 1018 56993 SGTC_1455 4262-0120 131 µM -1.45878960080686 0.0603294012400671 no 3118 0.0723115128468674 1006 1529587 SGTC_93 0109-0045 59.227 µM -1.46030960244454 0.0601381687271484 no 3119 0.0721025020841157 1035 88733 SGTC_309 k408-0051 1.48 µM -1.46090987400697 0.0600627789701314 no 3120 0.0720200882562292 996 3640463 SGTC_1346 1488-2224 62.4 µM -1.4637028704757 0.0597129716631915 no 3121 0.0716375754338508 997 3722427 SGTC_707 0865-0008 204 µM -1.47124849459077 0.0587759034937544 no 3122 0.0706119633681248 1034 723043 SGTC_1725 st036284 20.55 µM -1.47375880914927 0.0584667264803304 no 3123 0.0702732712063236 998 707914 SGTC_3305 9127027 53.8275 µM -1.4773994194321 0.0580206100870017 no 3124 0.0697843008520603 1005 41905295 SGTC_1351 1496-0003 46.5 µM -1.47981796388385 0.057725726208117 no 3125 0.0694609166500127 1030 3891978 SGTC_90 0870-0863 4.608 µM -1.48328273464094 0.0573053348577511 no 3126 0.0689996537808048 1022 1738164 SGTC_2919 7978188 46.38 µM -1.48647765888054 0.0569198233056203 no 3127 0.0685764109703981 999 2980291 SGTC_417 st075190 100 µM -1.48652814078314 0.0569137483994374 no 3128 0.0685697395623531 1028 222757 SGTC_2474 5321570 43.32 µM -1.48737720446225 0.0568116500108395 no 3129 0.0684576070221614 1032 2841384 SGTC_1686 st019653 115.5 µM -1.48921391872196 0.0565912819761447 no 3130 0.0682155233729987 1041 97252 SGTC_3278 9139605 49.47 µM -1.49347909624925 0.0560821461045929 no 3131 0.067655911043504 1019 7958859 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.49375907787626 0.0560488513491674 no 3132 0.0676193004929487 1026 2333 A French combination drug. SGTC_1350 1495-0454 146 µM -1.49581371429639 0.0558049955702655 no 3133 0.0673511032514045 1020 1069057 SGTC_663 1486-0733 13.9 µM -1.49754126469348 0.0556006086991848 no 3134 0.0671262383922321 1020 722445 YPR165W RHO1 SGTC_1841 st054148 70 µM -1.49759897306942 0.0555937914205069 no 3135 0.0671187368722591 1030 675442 SGTC_2644 guaiazulene 100 µM -1.49811515223799 0.0555328428319343 no 3136 0.0670516674979165 1003 3515 A coloring agent. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.50041489195349 0.0552619385826983 no 3137 0.0667534821795691 1004 5711223 A potent inhibitor of glutathione S-transferases. SGTC_454 lyso-paf C-16 6.67 µM -1.50076515496143 0.055220770121423 no 3138 0.0667081570965861 1020 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1802 st050112 57.9 µM -1.50110330499713 0.0551810483546707 no 3139 0.0666644220666656 1033 4662563 SGTC_1276 0871-0068 94.2 µM -1.50741429134681 0.0544438438092455 no 3140 0.0658522489176559 1023 3414906 SGTC_1473 k844-0725 134 µM -1.50794181101558 0.0543825772010766 no 3141 0.065784710196513 1021 54682906 SGTC_2122 5258151 111.688 µM -1.51082676571774 0.0540484801533992 no 3142 0.0654162967060566 1034 2173356 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.52348906085835 0.0526012752113593 no 3143 0.0638181977229021 1036 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1031 k035-0009 16 µM -1.5235875785027 0.0525901371623675 no 3144 0.0638058840209265 1030 5180959 SGTC_1977 st070720 65.3 µM -1.524886759316 0.0524434315009164 no 3145 0.0636436724806589 1012 682188 SGTC_3047 9092122 49.47 µM -1.52723411856332 0.0521791877560914 no 3146 0.0633514025512689 1024 17173831 SGTC_3218 9131285 49.47 µM -1.52844733952892 0.0520430298025253 no 3147 0.0632007544052641 1019 17156417 SGTC_1508 1080-0625 72.9 µM -1.53046845661386 0.0518168298271064 no 3148 0.0629504077411893 986 767111 SGTC_2130 NSC 7 2.4545 µM -1.53443538839115 0.0513751299464848 no 3149 0.0624612885882433 1036 21448 SGTC_2958 9077254 16.72 µM -1.53814195974547 0.0509651314607273 no 3150 0.0620069542451965 1029 16457351 SGTC_2475 5812728 15.03 µM -1.53848602455565 0.0509272055742604 no 3151 0.0619649115125241 1024 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2898 9056270 58.44 µM -1.53939683764187 0.0508269161007574 no 3152 0.0618537228020852 987 19154699 SGTC_1246 0422-0085 105 µM -1.54221297271169 0.0505178263990219 no 3153 0.061510924331833 1007 264295 SGTC_3124 9127567 49.47 µM -1.54404392639037 0.0503176715283548 no 3154 0.0612888457703544 1006 17592030 SGTC_157 1348-1695 65.819 µM -1.54486110482632 0.0502285440290873 no 3155 0.0611899316310851 997 5380510 SGTC_525 k781-2675 26.7 µM -1.54633443363261 0.0500681699387056 no 3156 0.0610119100163458 993 3651118 YDL195W SEC31 SGTC_2786 7743617 45.45 µM -1.54676304890525 0.0500215912539195 no 3157 0.060960196732519 1018 583674 SGTC_3089 9117425 49.47 µM -1.54747349972388 0.0499444609108151 no 3158 0.0608745549101333 1038 9401657 SGTC_274 sirtinol 40.1 µM -1.55164393324951 0.0494936070411043 no 3159 0.0603737224437993 1016 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2341 7987486 176.74 µM -1.5551239019435 0.0491198888151794 no 3160 0.0599582817129273 1026 1258686 SGTC_937 3122-0005 46.7 µM -1.55526693037841 0.0491045771657857 no 3161 0.0599412549136172 1022 759535 SGTC_2870 9038528 12.99 µM -1.55714272222976 0.0489041203307643 no 3162 0.0597183018851697 1042 6463316 SGTC_2737 bleomycin 30.5 nM -1.55749098767896 0.0488669749492042 no 3163 0.059676979326951 1021 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3350 9150499 3.57 µM -1.55907292752119 0.0486985317310043 no 3164 0.0594895602041626 1036 4910996 YPR165W RHO1 SGTC_1051 3253-3903 78 µM -1.56054062258898 0.0485426685241268 no 3165 0.0593160890242163 1018 5509239 SGTC_512 prima-1 270 µM -1.5622247275158 0.0483643151761255 no 3166 0.059117528649486 1035 322968 A re-activator of the apoptotic function of mutant p53. SGTC_258 haloperidol 50.781 µM -1.56539682737956 0.0480298009277315 no 3167 0.05874494593549 1031 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1039 k821-0043 94 µM -1.56650366267061 0.0479135161761966 no 3168 0.0586153758948833 1050 15992768 SGTC_988 1497-1057 103 µM -1.57499467452394 0.047028924655483 no 3169 0.0576288369000603 1033 3533044 SGTC_2679 rapamycin 1 nM -1.5755836307571 0.0469680562384804 no 3170 0.057560895511208 972 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2682 pyrogallin 40.03 µM -1.57646491764948 0.0468770935634297 no 3171 0.0574593488432843 1024 822798 An ATP competetive kinase inhibitor. SGTC_589 1227-0070 34.1 µM -1.57757303955237 0.0467629185341047 no 3172 0.0573318650818282 1042 2841384 SGTC_2843 9000894 45.46 µM -1.5800100631884 0.0465126052871417 no 3173 0.0570522809635367 1006 2242070 SGTC_1270 0831-1170 17.3 µM -1.58180812374694 0.0463286119734609 no 3174 0.0568466899583817 1021 6764716 SGTC_1298 1079-1278 263 µM -1.58269092136993 0.0462384905113232 no 3175 0.0567459642844767 1032 2840950 SGTC_2834 9001755 58.44 µM -1.58453027683782 0.0460511699220233 no 3176 0.0565365486592692 1013 2989575 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.58485769437482 0.0460178896105905 no 3177 0.0564993352117849 1038 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_96 0929-0093 37.281 µM -1.58649712600653 0.0458515402806957 no 3178 0.0563132917882161 1030 6991579 SGTC_1344 1488-0097 29.1 µM -1.58740731469701 0.0457593943645491 no 3179 0.0562102118512209 1041 747966 SGTC_1383 3049-0032 20.7 µM -1.58742277911157 0.0457578300610157 no 3180 0.0562084617742837 1024 712864 SGTC_2639 lactacystin 53 µM -1.59274860438399 0.0452216470866535 no 3181 0.0556082995581765 998 3870 A proteasome inhibitor. SGTC_2237 6667747 47.222 µM -1.59836554937762 0.0446616442538111 no 3182 0.0549808235064261 1052 729940 YDL015C TSC13 SGTC_2549 cedrol 20.94 µM -1.60141672865342 0.0443597943130093 no 3183 0.0546423249979341 1020 6708665 A sedative which affects the nervous system. SGTC_2784 7567673 72.73 µM -1.60293341102865 0.0442103634189031 no 3184 0.0544746781417821 1011 3471247 SGTC_2238 6671620 73.2395 µM -1.60430969754493 0.0440751164173117 no 3185 0.0543229022909303 1017 729941 SGTC_1200 1643-0193 18.4 µM -1.61131358498203 0.0433920080526719 no 3186 0.0535556956407173 1037 5403974 SGTC_3096 9117468 49.47 µM -1.61753305018439 0.0427925955239848 no 3187 0.0528816337495486 1018 41316311 SGTC_122 0236-0016 402.397 µM -1.61754398148436 0.0427915479217449 no 3188 0.0528804549739479 1013 6808838 SGTC_739 1486-1183 203 µM -1.61759637447654 0.0427865271218048 no 3189 0.0528748054704095 1034 4346692 SGTC_1495 4469-0029 237 µM -1.61869955601879 0.0426809201873599 no 3190 0.0527559612307427 1029 793680 SGTC_972 1319-0219 195 µM -1.61901573952376 0.0426506910069559 no 3191 0.0527219383184484 1037 23903702 SGTC_2553 4-methylesculetin 85.09 µM -1.62031493970288 0.0425266607438562 no 3192 0.0525823206451232 1030 5319502 SGTC_982 1491-0518 27.5 µM -1.62150163601375 0.0424136258858386 no 3193 0.0524550497000902 1034 3091256 SGTC_2407 paclitaxel 400 µM -1.62213254693337 0.0423536295564236 no 3194 0.0523874853259774 1037 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_339 3091-4833 71.4 µM -1.6224258549636 0.0423257608834236 no 3195 0.0523560984474511 1009 3240077 SGTC_993 3909-8757 62.7 µM -1.62472836037158 0.0421075032246891 no 3196 0.052110225818641 1034 4288324 YLR208W SEC13 SGTC_1492 4158-0558 28.5 µM -1.62538608816609 0.0420453238401618 no 3197 0.0520401591523169 1007 3967268 SGTC_3155 9099265 49.47 µM -1.62971889579093 0.0416375698765298 no 3198 0.0515804609360423 1029 25236499 SGTC_2736 butenafine 14.65 µM -1.63598139506537 0.0410538825205732 no 3199 0.050921740631476 1032 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1146 3579-1023 7 µM -1.63937378424126 0.0407404811552062 no 3200 0.0505677189871991 1046 X1146 SGTC_752 1896-0090 130 µM -1.64283280151881 0.0404229262482568 no 3201 0.0502087657556197 1044 772567 SGTC_8 0354-0001 70 µM -1.6456044434239 0.040169928730631 no 3202 0.0499226118659434 1049 4993152 SGTC_386 1509-0011 3.07 µM -1.64720317794425 0.0400245810222626 no 3203 0.0497581454212854 1033 3107280 SGTC_1041 0206-0046 107 µM -1.65282080740928 0.0395172442978267 no 3204 0.0491836690344625 1037 50494 SGTC_2420 aureobasidin a 50 nM -1.66055694193769 0.03882715656254 no 3205 0.0484012313909623 1036 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2693 st077581 40.7 µM -1.66287199753241 0.0386225649759488 no 3206 0.0481690303965361 1001 25238761 SGTC_1979 st071809 45.3 µM -1.66406359973659 0.0385176008066585 no 3207 0.0480498601536326 1043 4976333 SGTC_2121 5257820 149.641 µM -1.67297558943462 0.0377399251521728 no 3208 0.0471660508160756 1035 791256 SGTC_1864 st057645 30.4 µM -1.67546499561855 0.0375250000618864 no 3209 0.0469215167523685 1047 688666 SGTC_1746 st038117 42 µM -1.67625512967837 0.0374569924695441 no 3210 0.0468441149036095 1039 2898218 SGTC_2196 6573537 42.6665 µM -1.67980471930365 0.0371527166809459 no 3211 0.0464976583294823 1053 2903087 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.6802360763887 0.0371158781828051 no 3212 0.0464556963707662 1013 6708739 YPR165W RHO1 SGTC_1027 k015-0025 8.67 µM -1.68209734475365 0.0369572654122978 no 3213 0.0462749825955874 1046 3598955 SGTC_457 grayanotoxin iii 135 µM -1.68667737252396 0.0365693250369832 no 3214 0.0458327026573512 1020 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_422 cantharidin 155 µM -1.68750492774218 0.0364995855740329 no 3215 0.0457531515973993 1033 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_822 1487-0950 154 µM -1.69806191428002 0.0356194427013227 no 3216 0.0447480384232156 1031 1958375 SGTC_668 1682-0499 62.6 µM -1.70134961000554 0.0353489247854852 no 3217 0.0444386787194859 1057 682214 SGTC_2629 bisabolol 100 µM -1.70268659333891 0.0352393982377767 no 3218 0.0443133675612379 1048 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2730 imipramine 71.33 µM -1.70410467097216 0.0351235327761705 no 3219 0.0441807670755822 1028 3696 A tricyclic antidepressant. SGTC_2025 5147754 141 µM -1.70530625941723 0.0350256005947193 no 3220 0.0440686603993213 994 315777 YLR208W SEC13 SGTC_2204 7233102 200 µM -1.70655428952069 0.0349241206764737 no 3221 0.0439524637265822 1035 2172480 SGTC_1421 4029-0249 71.4 µM -1.7218324757448 0.0337012697595307 no 3222 0.0425499348923541 1040 2894095 SGTC_2518 prenyletin 46.28 µM -1.72622242431345 0.0333564919743055 no 3223 0.0421537026473205 1041 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3334 9142812 21.919 µM -1.72767442316241 0.0332430961199562 no 3224 0.0420233057814499 1040 45283678 SGTC_2107 5363541 170.161 µM -1.73249793021428 0.0328686749114158 no 3225 0.0415924726469281 1037 244052 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.73331880368819 0.0328053026556619 no 3226 0.0415195102057518 1011 279621 SGTC_514 4466-0038 2.65 nM -1.73668645164315 0.0325463702768642 no 3227 0.0412212652341447 992 5722064 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.74102499562073 0.0322152746378517 no 3228 0.0408395986077277 1039 756377 SGTC_44 0929-0055 61.211 µM -1.74789267793217 0.031696855125765 no 3229 0.0402413064875385 1017 1379590 SGTC_1098 clofazimine 15.1 µM -1.7479314066809 0.0316939512790334 no 3230 0.0402379528506386 1044 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3226 9131256 49.47 µM -1.75487629466984 0.031176772546177 no 3231 0.0396402348784886 1031 17178073 SGTC_2860 9025725 38.96 µM -1.76083054384463 0.0307389422641021 no 3232 0.0391335442469643 1058 40546248 SGTC_848 0368-0089 85.6 µM -1.76329127225939 0.0305594917120072 no 3233 0.0389256882817983 1040 762535 SGTC_912 3474-0017 2.18 µM -1.76661922211244 0.0303181794707853 no 3234 0.0386460097999779 1054 3360550 SGTC_2065 5221596 34.26 µM -1.76899892503237 0.0301465953833982 no 3235 0.0384470269891479 1037 788581 SGTC_3346 9158254 43.5805 µM -1.78852989399768 0.0287685503910749 no 3236 0.0368452785513314 1050 17639500 SGTC_46 0329-0187a 2.197 µM -1.78992756881801 0.0286719762078365 no 3237 0.0367327781024635 1046 46494817 SGTC_3058 9093861 49.47 µM -1.79773907125762 0.0281371816620207 no 3238 0.0361091833553225 1040 17217477 SGTC_933 2914-0560 114 µM -1.79802092762349 0.0281180413806265 no 3239 0.0360868457224637 1042 463887 SGTC_800 3448-7362 155 µM -1.80675407726105 0.0275303414941572 no 3240 0.0354003159279048 1059 15991913 SGTC_545 4218-0007 221 µM -1.81140546287765 0.0272215277318718 no 3241 0.0350390554857401 1057 2840508 SGTC_1920 st075728 45.7 µM -1.81201894695365 0.0271810139737445 no 3242 0.034991634481703 1034 3400306 SGTC_2045 5106652 78.05 µM -1.81328504731736 0.0270975612436926 no 3243 0.0348939341588186 1032 673349 SGTC_1587 estradiol valerate 56.1 µM -1.81988801679849 0.0266657961486371 no 3244 0.0343880300824111 1059 13791 A steroid. SGTC_2235 salicylic acid 500 µM -1.82955474560434 0.026044069010647 no 3245 0.0336582729917998 1070 338 A COX inhibitor and kinase inhibitor. SGTC_1991 st073000 8.92 µM -1.83517485767382 0.02568821120493 no 3246 0.033239892590249 1065 4301969 YIL048W NEO1 SGTC_2638 epoxomicin 18 µM -1.84477338345563 0.0250898596055548 no 3247 0.0325352554022833 1056 9915668 A protesome inhibitor. SGTC_2630 antimycin a 100 µM -1.84622313399899 0.0250005088219782 no 3248 0.0324299066235662 1052 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_449 xestospongin c 11.1929 µM -1.84686323694061 0.0249611430842094 no 3249 0.0323834820162044 1067 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1866 st057638 64 µM -1.84945887857592 0.0248020458010501 no 3250 0.0321957901665281 1034 688802 SGTC_1049 3226-0134 66 µM -1.85207037880771 0.0246428357113181 no 3251 0.0320078586848549 1058 5702385 SGTC_3178 9107506 49.47 µM -1.86364171620059 0.0239476703442593 no 3252 0.0311860176380932 1059 8897194 SGTC_2555 cholic acid 100 µM -1.86937870592476 0.023609169317978 no 3253 0.0307850725010699 1054 6708657 Influences liver metabolism. SGTC_1128 3448-9350 235 µM -1.87496345433323 0.023283525480556 no 3254 0.0303988756917058 1044 619386 SGTC_1302 1159-0335 255 µM -1.87889982893555 0.023056275868936 no 3255 0.0301290861097862 1062 649284 SGTC_3114 9122766 49.47 µM -1.89755158530736 0.0220047340358053 no 3256 0.0288775886419398 1045 17176985 SGTC_297 0986-0032 24 µM -1.89967560823052 0.0218875957116339 no 3257 0.0287378516067526 1047 2847425 SGTC_921 1561-0023 372 µM -1.90291647649469 0.0217098791067714 no 3258 0.0285257223381341 1054 24050882 SGTC_1486 3970-0793 4.53 µM -1.90518673259187 0.021586114469226 no 3259 0.0283779010995272 1065 2844330 SGTC_2360 9040895 200 µM -1.90724510132905 0.0214744169099773 no 3260 0.0282444278014243 1054 4914414 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.91070596944441 0.0212877139617757 no 3261 0.0280211886273834 1041 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2050 5263056 171 µM -1.91391010975166 0.0211160862479128 no 3262 0.0278158212042783 1058 763468 YGL055W OLE1 SGTC_2266 7929956 200 µM -1.92018940153236 0.020783133709364 no 3263 0.0274169899291174 1055 2967153 SGTC_2329 6138490 200 µM -1.92096842216252 0.0207421386222381 no 3264 0.027367844325965 1062 720019 SGTC_321 4534-3890 65.3 µM -1.92795358879962 0.0203776023556684 no 3265 0.0269304496176292 1051 699746 SGTC_3293 9120939 62.045 µM -1.93745024001887 0.0198907195604824 no 3266 0.0263451652002117 1062 934087 SGTC_2284 7945075 39.21 µM -1.94359648654022 0.0195808990444838 no 3267 0.0259720649275772 1046 1245402 SGTC_2480 5767542 37.17 µM -1.98287322065744 0.0176962702083828 no 3268 0.0236907963052379 1061 2867358 SGTC_2029 5175081 200 µM -1.98602473827702 0.0175519953078774 no 3269 0.0235152885543739 1069 1380876 SGTC_597 k018-0003 82.8 µM -1.99416138564713 0.0171841386531148 no 3270 0.0230672102790484 1074 6786234 SGTC_681 1642-0006 26.6 µM -2.00262542147542 0.0168084913488027 no 3271 0.022608754567886 1084 4446530 SGTC_2201 6605497 169.863 µM -2.00301105214592 0.016791545057948 no 3272 0.0225880511015963 1074 670741 SGTC_1050 3232-1156 69.3 µM -2.00637185661496 0.0166444743567109 no 3273 0.0224082943380359 1066 700529 SGTC_1901 st060216 58.6 µM -2.00994837075495 0.0164891760857834 no 3274 0.0222183267509769 1047 688792 SGTC_123 0083-0120 66.675 µM -2.01135412925346 0.0164284761534793 no 3275 0.0221440324099154 1076 16001701 SGTC_2439 5492030 7.2 µM -2.01571145565071 0.0162415431099483 no 3276 0.0219150785114557 1042 5722370 SGTC_2402 5553605 200 µM -2.01662605004585 0.0162025384302399 no 3277 0.0218672761980162 1068 6758546 SGTC_2996 9066192 71.4286 µM -2.02036381266857 0.0160439672159936 no 3278 0.0216728320734218 1054 6472854 SGTC_998 3996-0085 177 µM -2.02208752705865 0.015971289475225 no 3279 0.0215836551754229 1071 715391 SGTC_2082 5219693 150 µM -2.02264737801254 0.0159477450282593 no 3280 0.0215547579077884 1061 2834649 SGTC_605 1315-0399 119 µM -2.05177392468565 0.014763197928903 no 3281 0.0200958192717895 1079 24020461 SGTC_2670 beta-carotene 100 µM -2.05204589889605 0.0147525036718138 no 3282 0.0200826009804132 1056 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2708 st078559 56 µM -2.0526243566061 0.0147297803785626 no 3283 0.0200545117227277 1048 17250902 SGTC_546 peri-Naphthalide 147 µM -2.06520466646242 0.0142429891018774 no 3284 0.0194518195916127 1063 223824 A penicillin ester. SGTC_2584 androsterone 48.74 µM -2.07073994825597 0.0140332322583865 no 3285 0.0191915524235862 1020 2754130 A steroid. SGTC_858 0438-0351 2.77 µM -2.07192101419024 0.013988822616277 no 3286 0.0191364039360575 1081 2799119 SGTC_485 niflumic acid 177 µM -2.09054326732679 0.0133044525714476 no 3287 0.018284512971963 1086 4488 A COX2 inhibitor. SGTC_1408 3909-7976 48.8 µM -2.10099995825029 0.0129329963761076 no 3288 0.0178204849570691 1073 24152374 SGTC_3216 9129716 49.47 µM -2.10503258947091 0.0127921588675234 no 3289 0.0176442356672785 1050 8056934 SGTC_938 3126-1755 342 µM -2.12276144409522 0.0121886149617062 no 3290 0.0168869236169384 1068 1777771 SGTC_1740 st038286 13.222 µM -2.12505679712222 0.0121123078805652 no 3291 0.0167909369595456 1059 716786 SGTC_671 0560-0003 407 µM -2.13760040577832 0.0117025801104553 no 3292 0.0162745943939795 1078 3238678 SGTC_56 0957-0365 83.25 µM -2.14246899587379 0.0115468226420665 no 3293 0.016077880490232 1073 6752360 SGTC_3025 9087895 49.47 µM -2.14947959106235 0.0113257013406855 no 3294 0.0157982011040789 1066 17173641 SGTC_2608 thymoquinone 42.66 µM -2.15530672964295 0.0111447171973095 no 3295 0.0155689197665882 1069 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3017 9080681 49.47 µM -2.16532344131482 0.0108394830960814 no 3296 0.0151814622117782 1072 16451914 SGTC_1284 0929-0043 16 µM -2.18007176259136 0.0104033155859153 no 3297 0.0146260712535452 1071 1239883 SGTC_669 0108-0021 26.2 µM -2.18382696015707 0.0102947332668708 no 3298 0.0144874828595822 1065 17201 SGTC_2176 5809774 33.9695 µM -2.20015062192614 0.0098341361449922 no 3299 0.0138981051472096 1054 2870539 SGTC_2994 9053520 71.4286 µM -2.23213096639492 0.00898368695066054 no 3300 0.0128031541652626 1073 4647384 SGTC_2997 9067075 71.4286 µM -2.23325305345361 0.0089550549824397 no 3301 0.0127661307504323 1059 27209819 SGTC_145 3737-0113 38.366 µM -2.25805810974891 0.00834220948511859 no 3302 0.0119710184128609 1071 6849351 SGTC_3324 9138759 60.749 µM -2.2816561412245 0.00779368469296496 no 3303 0.0112548246877262 1076 45595710 SGTC_466 geldanamycin 89.2 µM -2.28760420105004 0.00766053519886498 no 3304 0.0110802905170166 1081 5288382 HSP90 inhibitor. SGTC_1401 3807-4679 7.6 µM -2.32167699526685 0.00693571647839196 no 3305 0.0101251672792394 1076 3291456 SGTC_492 tmb-8 126 µM -2.33025144280998 0.00676313578480048 no 3306 0.00989643275553532 1089 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2126 5251174 33.877 µM -2.33071897844589 0.0067538355879085 no 3307 0.00988409139309225 1076 790722 SGTC_950 1165-0508 94.1 µM -2.33940488322733 0.00658309917820527 no 3308 0.00965724452415613 1076 6148369 SGTC_1217 1183-1422 255 µM -2.35666776360897 0.00625506055151848 no 3309 0.00921986816817211 1077 2849664 SGTC_1719 st032227 49.2 µM -2.3577717141674 0.00623458382144202 no 3310 0.00919249756142114 1062 3125804 SGTC_2938 9059746 27.26 µM -2.36335187692132 0.00613198539183632 no 3311 0.00905523238820262 1073 6471769 SGTC_3142 9086498 49.47 µM -2.36393227388098 0.00612140041504537 no 3312 0.00904105891853947 1042 25236367 SGTC_3021 9087658 49.47 µM -2.38606636652126 0.00572962296218177 no 3313 0.00851483876954845 1080 25237042 SGTC_2478 5763493 32.33 µM -2.43180995192266 0.00498976034728526 no 3314 0.00751179396032117 1074 1365576 YLR208W SEC13 SGTC_751 0833-0568 350 µM -2.44585680955611 0.00478030935552265 no 3315 0.00722541899801737 1086 6954252 SGTC_680 0417-1641 114 µM -2.47010873364333 0.00443708331632791 no 3316 0.00675359945049857 1079 2835990 SGTC_1836 st055642 81 µM -2.47832945269304 0.00432583696206779 no 3317 0.00659995997523169 1084 8571 SGTC_2033 5192550 145 µM -2.50401630195419 0.00399412022659414 no 3318 0.00613961881544663 1076 182073 SGTC_1736 st036774 51 µM -2.50590858662888 0.00397060887241571 no 3319 0.00610685960915447 1079 1272247 SGTC_2953 9074162 66.49 µM -2.52931145040004 0.00368990947786289 no 3320 0.00571432808148912 1073 16451992 SGTC_2809 7964133 12.99 µM -2.5308722807581 0.00367183765383222 no 3321 0.00568896352386705 1084 1253665 SGTC_2900 5328528 85.29 µM -2.53362887213857 0.00364011477140349 no 3322 0.00564441108584961 1075 795359 SGTC_1397 3532-0190 20.1 µM -2.58014920137493 0.00314059786563896 no 3323 0.00493788182659169 1091 5322280 SGTC_1274 0865-0114 173 µM -2.58359648478772 0.00310616128353414 no 3324 0.00488880571618032 1089 870624 SGTC_3032 9089427 49.47 µM -2.61609341193802 0.00279786230171288 no 3325 0.00444711107208647 1051 17173707 SGTC_1723 st034307 2.5525 µM -2.64438815956733 0.00255221581790801 no 3326 0.00409193734438898 1076 867466 SGTC_62 0180-0423 3.232 µM -2.64804587521982 0.0025219259881605 no 3327 0.00404792691426102 1085 30102 YGL099W LSG1 SGTC_2135 5326629 150.42 µM -2.65310490166832 0.00248056737461682 no 3328 0.0039877540019262 1080 5020077 SGTC_58 0957-0393 9 µM -2.66049237371727 0.00242127459495523 no 3329 0.00390132471208681 1083 6997992 SGTC_1714 st033236 13.627 µM -2.67301643457135 0.00232367832823335 no 3330 0.00375862837952589 1082 2916566 SGTC_1722 st034304 3.6505 µM -2.70273208771679 0.00210620945919608 no 3331 0.00343860768230407 1089 4036148 YLR033W RSC58 SGTC_1311 1190-0148 100 µM -2.72872235190031 0.00193132230232784 no 3332 0.00317901053058301 1088 1961333 SGTC_190 3970-0790 3.722 µM -2.76655935648108 0.00170023765056819 no 3333 0.00283256353903713 1091 2832352 SGTC_2946 9065502 71.43 µM -2.78881035886238 0.00157639177932753 no 3334 0.00264510161550938 1072 16489101 SGTC_855 0428-0020 25 µM -2.79963921620814 0.00151914525832214 no 3335 0.00255798753992821 1085 6812414 SGTC_2239 6685329 187.64 µM -2.83519000993994 0.0013442817136473 no 3336 0.00228992187258487 1082 805680 SGTC_1445 4239-0156 97.7 µM -2.91473307561181 0.00101768179096729 no 3337 0.00177996437545132 1093 4008346 SGTC_1280 0880-0253 10.1 µM -2.93863492349268 0.000934834896471603 yes 3338 0.0016483056739162 1088 6836607 SGTC_2533 agelasine 13.65 µM -2.9879400023272 0.000783165480710051 yes 3339 0.00140432342427308 1090 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1732 st034308 51.822 µM -2.98995302779687 0.000777483898140971 yes 3340 0.00139510175334698 1078 830119 SGTC_3030 9087619 49.47 µM -2.99053928658812 0.000775836386602846 yes 3341 0.00139242651934042 1085 25236973 SGTC_3118 9124250 49.47 µM -3.00695664811263 0.000730985482763152 yes 3342 0.00131938695874217 1091 1504786 SGTC_2944 9067346 25.62 µM -3.07277614491881 0.000574126985689774 yes 3343 0.00106038756027391 1086 6473075 SGTC_1828 st055811 49 µM -3.10736139954303 0.000504782523248745 yes 3344 0.000943827386870435 1093 5877589 SGTC_1737 st035557 69.7 µM -3.11952563024291 0.000482296018621098 yes 3345 0.000905712504521628 1078 5716916 SGTC_946 3434-1334 87.4 µM -3.20458357312457 0.000349188115731914 yes 3346 0.000676290083007491 1090 4047976 SGTC_2935 9038016 29.96 µM -3.23864367950323 0.000306181388042603 yes 3347 0.000600497560451604 1087 6463195 SGTC_187 1488-2104 32.728 µM -3.25032103133906 0.00029260917245225 yes 3348 0.000576373994082386 1093 2852859 SGTC_2978 9011784 42.97 µM -3.28156998730261 0.000258994463094843 yes 3349 0.000516154511750758 1088 2994934 SGTC_2582 agaric acid 100 µM -3.51071779132359 0.000102589062008607 yes 3350 0.000223449279403414 1085 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3266 9136860 49.47 µM -3.89993555165259 1.87494007680476e-05 yes 3351 4.81091486435748e-05 1086 4871271 YPR165W RHO1 SGTC_3205 9113483 49.47 µM -3.9093414987402 1.79593090316695e-05 yes 3352 4.62740276552278e-05 1090 17018033 SGTC_160 3453-0671 289.699 µM -4.12318588233426 6.57959370009317e-06 yes 3353 1.86833956695589e-05 1093 5322268 SGTC_73 0327-0325 16.231 µM -4.31053735027863 2.62290229543502e-06 yes 3354 8.14291587162851e-06 1081 53298 SGTC_2934 9036370 36.88 µM -4.67642295225966 3.90689212443207e-07 yes 3355 1.45961104150093e-06 1094 6462800 SGTC_951 1171-0579 82.7 µM -4.7397246085091 2.76979010951146e-07 yes 3356 1.07004443282331e-06 1092 1616050 YPR165W | YDR526C RHO1 | YDR526C