SGTCid condition conc unit TCP1|YDR212W.score TCP1|YDR212W.strain.pval TCP1|YDR212W.strain.significant TCP1|YDR212W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1875 nocodazole 6 µM 17.055644237859 1.61293705729068e-46 yes 1 1.58677320953526e-65 3 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_229 benomyl 22.8748 µM 9.82473951279553 1.09269348012341e-16 yes 2 4.4050750427217e-23 4 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2151 5563267 85.4165 µM 9.37644538799063 2.33208834730885e-15 yes 3 3.41171802110366e-21 6 5310824 SGTC_115 0527-0192 112.043 µM 6.92256465657246 3.76589063917429e-09 yes 4 2.21769620931323e-12 2 4233931 SGTC_212 3807-4682 38.772 µM 6.79231655166541 7.16361318395182e-09 yes 5 5.51735441989401e-12 11 3125501 YBL034C STU1 SGTC_962 1254-0300 21.5 µM 6.77054564331997 7.96744848094555e-09 yes 6 6.41487997641127e-12 1 7340576 SGTC_514 4466-0038 2.65 nM 6.60488723593296 1.770738729286e-08 yes 7 1.98910018372927e-11 11 5722064 SGTC_1062 mesoridazine 14.2 µM 6.16891216539368 1.32452236965374e-07 yes 8 3.43807045154094e-10 1 4078 A neuroleptic. SGTC_2993 9054257 71.4286 µM 6.10360678400361 1.77059078809904e-07 yes 9 5.1850614391903e-10 11 6470217 YGL055W OLE1 SGTC_3056 9094900 49.47 µM 5.68267378371945 1.07259909871503e-06 yes 10 6.63025280646484e-09 1 25236784 SGTC_313 3474-0040 5.03 µM 5.39764962631921 3.39269433936335e-06 yes 11 3.3759779623521e-08 3 1043375 YIL048W NEO1 SGTC_1065 prochlorperazine maleate 2.48 µM 5.37541316096905 3.70303666391015e-06 yes 12 3.82036353864379e-08 2 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 5.30474323465672 4.87984289995866e-06 yes 13 5.64158508529978e-08 5 5355888 SGTC_136 0097-0015 404.482 µM 5.20715267314427 7.10399247298039e-06 yes 14 9.5880157027245e-08 3 4861337 SGTC_2912 7964298 10.93 µM 5.08776666842881 1.11489648652527e-05 yes 15 1.81152369518523e-07 29 2975850 SGTC_1348 1493-0373 93.8 µM 4.79639678628801 3.21708768525607e-05 yes 16 8.07725674908871e-07 1 3010129 SGTC_928 2764-0428 58.7 µM 4.69452477884096 4.5976970875829e-05 yes 17 1.33613609606959e-06 14 662578 SGTC_1643 st009866 20.2 µM 4.51875430804886 8.37582828043768e-05 yes 18 3.1102263580491e-06 19 3156273 YOR207C RET1 SGTC_3126 9127922 49.47 µM 4.50216753303607 8.8541438743803e-05 yes 19 3.363196280067e-06 23 45595682 SGTC_316 k060-0003 58.6 µM 4.38958819966329 0.000128453091122915 yes 20 5.67827555827342e-06 3 6152314 SGTC_1293 1000-1278 195 µM 4.37818342487503 0.000133324747752508 yes 21 5.98363068799816e-06 3 678847 SGTC_124 0136-0217 7.121 µM 4.31707124532888 0.000162516411354526 yes 22 7.90565676076078e-06 20 3976905 SGTC_2601 securinine 100 µM 4.31007718644562 0.000166214658219859 yes 23 8.15987871235197e-06 16 442872 A GABA receptor antagonist. SGTC_3351 9150312 21.596 µM 4.30108097913739 0.000171087418769355 yes 24 8.49834639784402e-06 7 4904905 SGTC_143 4032-1194 15.74 µM 4.3005216042796 0.000171394772453885 yes 25 8.51982787278997e-06 12 1806963 SGTC_1179 1021-1431 9.29 µM 4.28424040120396 0.000180570232212628 yes 26 9.16822826026176e-06 5 2840958 SGTC_140 0062-0056 502.533 µM 4.10815443108405 0.000313848516186043 yes 27 1.99416699067218e-05 3 3758964 SGTC_1042 0350-0096 82 µM 4.05101184791176 0.000373862750919802 yes 28 2.5498312461073e-05 8 3122515 SGTC_675 1309-0189 238 µM 4.02609048351077 0.000403237520422448 yes 29 2.83559366525505e-05 4 4246530 SGTC_958 1222-0007 33 µM 4.0048822700692 0.000429907621344466 yes 30 3.10241878597091e-05 4 7312461 SGTC_3071 9117417 49.47 µM 3.98538809905534 0.000455856058753213 yes 31 3.36849605223057e-05 15 45595590 YGL055W OLE1 SGTC_754 3474-0146 171 µM 3.93606063790514 0.000528136438027762 yes 32 4.14150261412621e-05 4 24762078 SGTC_252 miconazole 1.30953 nM 3.86133389976945 0.000658038173838286 yes 33 5.63848325112942e-05 16 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_104 0074-0074 590.992 µM 3.85295681795492 0.000674307535441157 yes 34 5.83499888130222e-05 17 3943124 SGTC_2706 st078239 82.5 µM 3.84040291473347 0.000699384577682777 yes 35 6.14162715020157e-05 3 15434492 SGTC_65 0798-0905 34.986 µM 3.820508833555 0.000740890550962896 yes 36 6.658831749917e-05 8 3602145 SGTC_640 3381-0960 37.1 µM 3.81235851532558 0.000758541174264187 yes 37 6.88235120433489e-05 11 1745025 SGTC_1804 st050076 49.1 µM 3.80436126517086 0.000776236059389006 yes 38 7.10852826376779e-05 5 3895976 SGTC_397 arbidol 50 µM 3.79671470116809 0.000793509738706265 yes 39 7.33131870423667e-05 7 131410 A RNA synthesis inhibitor. SGTC_2393 9031399 185.94 µM 3.79022577921715 0.000808445120331872 yes 40 7.52552065483534e-05 14 1526623 YDL150W RPC53 SGTC_2465 5809242 33.21 µM 3.78711594365088 0.000815694278542496 yes 41 7.62029973551653e-05 1 2731748 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.77852857079029 0.000836023600309549 yes 42 7.88788775700892e-05 12 1377 SGTC_2823 7987624 58.44 µM 3.75233708989673 0.000900941681922842 yes 43 8.759683862653e-05 16 2239440 SGTC_2101 5377231 179.231 µM 3.74364802185863 0.000923481495894341 yes 44 9.06838374952873e-05 7 2844213 SGTC_2576 guaiol 23.12 µM 3.71350134932384 0.00100576034226509 no 45 0.000102205687269425 8 227829 SGTC_969 1313-0238 134 µM 3.71169537094506 0.00101089676300611 no 46 0.000102937835469949 22 5212874 SGTC_2405 ticlatone 3.52 µM 3.70417023997493 0.00103255929724935 no 47 0.000106041899394179 23 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1064 honokiol 6.76 µM 3.69835342306009 0.00104959503254119 no 48 0.000108501301482435 12 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3201 9113999 49.47 µM 3.69660824183672 0.00105475619801264 no 49 0.000109249560937445 8 16649224 SGTC_1360 1598-0022 39.8 µM 3.69299245539276 0.00106552359823559 no 50 0.000110815300398905 12 761525 SGTC_2870 9038528 12.99 µM 3.6746236931465 0.00112179674257298 no 51 0.000119100112868798 6 6463316 SGTC_721 1187-1332 279 µM 3.66889590376081 0.00113989312118846 no 52 0.000121800117421159 12 25730 SGTC_108 0509-0257 621.132 µM 3.65579233470905 0.00118230255032316 no 53 0.000128194423787603 17 536624 SGTC_2989 9073649 71.4286 µM 3.6489451747161 0.0012050333960403 no 54 0.000131659643562488 16 21367202 SGTC_760 0568-0725 82.9 µM 3.58772648134939 0.0014267627176433 no 55 0.000166786973520663 3 3916171 SGTC_3145 9085516 49.47 µM 3.57173408002379 0.00149052361683003 no 56 0.000177312694652484 17 25236195 SGTC_1262 0737-0114 49.6 µM 3.564977929135 0.0015182328368262 no 57 0.000181943404198092 7 765919 SGTC_1448 4255-0083 152 µM 3.54768839817097 0.00159129575840597 no 58 0.000194313849683226 6 5399660 SGTC_2606 farnesol 9.78 µM 3.51116781657039 0.00175626479080018 no 59 0.000223071329808381 15 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2085 5307070 144.047 µM 3.46811499222999 0.00197063872152992 no 60 0.000262061479419508 13 2840351 SGTC_534 k292-0788 63.4 µM 3.4509254345273 0.00206267516638949 no 61 0.000279333947856428 15 4146317 SGTC_1545 lovastatin 49.4 µM 3.41188629476338 0.00228635072430726 no 62 0.000322575090946698 12 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1876 myriocin 605 nM 3.40953739942589 0.00230048474807412 no 63 0.000325365774834009 11 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3225 9130819 49.47 µM 3.39591123176432 0.00238404992158967 no 64 0.000342002693396996 16 4547121 SGTC_289 k017-0060 526 µM 3.38732893784715 0.00243808286939305 no 65 0.000352883570057202 3 5512909 SGTC_1052 3253-3998 198 µM 3.36703416208536 0.00257028964228005 no 66 0.000379906376660298 9 5450317 SGTC_1512 0259-0544 12.2 µM 3.35942934871561 0.00262147559292277 no 67 0.000390518096733779 9 18476 SGTC_2174 5790901 200 µM 3.35046226095865 0.00268301256515042 no 68 0.000403384009431286 15 786020 SGTC_2144 5628481 200 µM 3.33320780884207 0.0028051040398238 no 69 0.000429253967489644 5 2818399 SGTC_195 4234-0266 16.654 µM 3.32856905118551 0.0028387715343447 no 70 0.000436466812847908 24 2303354 SGTC_887 0885-0007 9.62 µM 3.30810576958378 0.00299168319792822 no 71 0.00046964663636282 17 5719458 SGTC_560 2332-1943 155 µM 3.28721573485289 0.00315540090787475 no 72 0.000505916431494733 8 21177716 SGTC_3350 9150499 3.57 µM 3.26114449433807 0.00337101404391249 no 73 0.000554817395485835 23 4910996 YPR165W RHO1 SGTC_2423 st077119 87.2 µM 3.26107781408506 0.00337158207490173 no 74 0.000554947886271956 6 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2792 7535235 81.82 µM 3.2363485471595 0.00358827270681352 no 75 0.000605347269886581 19 1281891 SGTC_399 oxolinic acid 75 µM 3.19180425216448 0.00401033490260886 no 76 0.000706935579053448 8 4628 A DNA gyrase inhibitor. SGTC_3081 9117243 49.47 µM 3.19094775498144 0.00401886868829502 no 77 0.000709034602850888 44 45595589 SGTC_1574 spiramycin 23.7 µM 3.18188927810653 0.00411012391014674 no 78 0.000731588718235774 16 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2319 6033012 152.6 µM 3.17659981884834 0.00416426341922648 no 79 0.000745062496348238 9 847246 SGTC_3322 9139058 2.11 µM 3.16897677605324 0.00424341035313716 no 80 0.000764883090683464 21 4908926 YPR165W RHO1 SGTC_680 0417-1641 114 µM 3.15294470614944 0.00441426866515294 no 81 0.0008081620989722 14 2835990 SGTC_795 0685-0265 78 µM 3.15017188448304 0.00444443502893605 no 82 0.000815872153167435 33 302754 SGTC_541 4513-1321 94 µM 3.14912462248312 0.00445587633032036 no 83 0.000818801719000965 19 747515 SGTC_1503 4585-0012 61.3 µM 3.13300505183536 0.00463533136540908 no 84 0.000865132320465235 15 2922052 SGTC_1145 3546-0597 10.2 µM 3.08214903629693 0.00524450905907239 no 85 0.00102755957434975 9 875334 SGTC_2342 7990637 118.86 µM 3.07748036425458 0.00530385285305212 no 86 0.00104379295782025 17 2033102 YER133W GLC7 SGTC_536 3852-0578 10.6 µM 3.06867306554084 0.00541743101131472 no 87 0.00107505874896697 8 2869208 SGTC_197 4544-0043 41.561 µM 3.02079574050129 0.00607348557709319 no 88 0.00126055685088417 34 896523 SGTC_2584 androsterone 48.74 µM 3.01750492214717 0.00612106323595789 no 89 0.00127432451027956 43 2754130 A steroid. SGTC_248 streptozotocin 5.23457 mM 3.01124631711912 0.00621246026081772 no 90 0.00130088851455772 28 5300 DNA alkylating agent. SGTC_2399 5884133 200 µM 3.00620315094139 0.00628698495685029 no 91 0.00132266100161814 29 722445 SGTC_677 0929-0063 136 µM 2.9992788053978 0.00639059762280109 no 92 0.00135309771665049 5 1539583 SGTC_3356 9151811 4.48 µM 2.96488614659224 0.00692794630673221 no 93 0.00151397484270373 10 1859254 YPR165W RHO1 SGTC_620 0109-0052 432 µM 2.96160609654012 0.00698122033019278 no 94 0.00153019516838286 14 493037 SGTC_3285 9112818 20.8695 µM 2.95350754793497 0.00711430720377593 no 95 0.00157092462577357 33 17017947 YPR165W RHO1 SGTC_630 4356-0227 183 µM 2.95118701584673 0.00715285179259594 no 96 0.00158277592793291 18 779312 SGTC_391 gliotoxin 8.33 µM 2.93607905054056 0.00740833269100775 no 97 0.00166194803335698 17 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_47 0149-0135 24.25 µM 2.9314186987093 0.00748874725780322 no 98 0.00168708836375773 14 5239155 SGTC_119 0121-0043 24.815 µM 2.93012151790941 0.00751126653377343 no 99 0.00169414736700302 40 1092378 SGTC_2304 7443016 91.4 µM 2.89621741638376 0.00812138688262001 no 100 0.00188845314493243 14 939854 SGTC_2214 7179297 48.276 µM 2.87402790035905 0.00854389549109935 no 101 0.00202636579876513 10 769744 SGTC_3266 9136860 49.47 µM 2.86746573032692 0.0086724853159202 no 102 0.00206886806701841 29 4871271 YPR165W RHO1 SGTC_1641 st009299 47.1 µM 2.86180958738635 0.00878467969029231 no 103 0.00210614945028455 25 4046054 SGTC_419 nsc-638432 893 µM 2.8533098118471 0.00895567247158765 no 104 0.00216332088345922 16 368090 SGTC_1755 st041960 45.185 µM 2.85278440442796 0.00896633731301043 no 105 0.00216690064663563 21 2257073 SGTC_1993 st073995 70.8 µM 2.84551088742052 0.00911512397903319 no 106 0.00221701218186657 16 3098394 SGTC_2345 9052315 157.45 µM 2.83796129661899 0.00927183998178701 no 107 0.00227013438100674 20 6469265 SGTC_698 k064-0052 127 µM 2.83490718785286 0.00933590460436847 no 108 0.00229195003312336 16 5088751 SGTC_1075 aripiprazole 15.2 µM 2.81470087123475 0.00976960234461036 no 109 0.00244113274885393 15 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1357 1503-1303 39.5 µM 2.781662445561 0.0105166749049687 no 110 0.00270406287984526 26 292895 SGTC_2572 astragaloside iv 100 µM 2.77339275109331 0.0107112847171065 no 111 0.00277375614333191 26 45006101 An anti-inflammatory agent. SGTC_2089 5281248 129.67 µM 2.77077398802783 0.010773562050154 no 112 0.0027961614457472 24 2737878 SGTC_2469 5655019 90.81 µM 2.7604674328865 0.0110217360332755 no 113 0.00288593561890733 13 2788239 SGTC_2128 5255449 168.493 µM 2.75906122476526 0.0110559790707683 no 114 0.00289838367559835 27 736008 SGTC_3311 9131146 2.8755 µM 2.74735986852326 0.0113445290908482 no 115 0.00300385877302297 39 4900406 YPR165W RHO1 SGTC_3303 9125618 40.5795 µM 2.73061775696595 0.0117687527721845 no 116 0.00316078723087502 25 22695467 SGTC_579 4491-1009 110 µM 2.72952405837974 0.0117969385848619 no 117 0.0031712910470634 30 1271041 SGTC_804 1595-0054 20.9 µM 2.71194236570665 0.0122581427237881 no 118 0.00334451110039956 21 761523 Stimulates phospholipase C. SGTC_570 0987-0065 62.6 µM 2.69944623695261 0.0125953670221878 no 119 0.00347274884759774 17 3104428 SGTC_1722 st034304 3.6505 µM 2.69421262632089 0.0127389712967595 no 120 0.00352775696824323 33 4036148 YLR033W RSC58 SGTC_2654 protoveratrine a 100 µM 2.67051324289464 0.0134071237552848 no 121 0.00378676920145837 16 5702278 A heart drug and vasodilator. SGTC_2934 9036370 36.88 µM 2.66810259153826 0.0134767527223859 no 122 0.00381404808302345 15 6462800 SGTC_2134 5324836 1.464 µM 2.6651583438907 0.0135622173201904 no 123 0.00384760400111596 13 699272 SGTC_2228 7354201 200 µM 2.66392092757472 0.0135982759888443 no 124 0.00386178576618717 17 753451 SGTC_375 3970-0961 9.27 µM 2.66294035853155 0.0136269087846035 no 125 0.00387305710792847 23 2898222 SGTC_1168 k815-0004 80.5 µM 2.65492329498149 0.0138629662382012 no 126 0.00396632220884283 45 642433 SGTC_1108 betulinic acid 729.144 nM 2.65205023869754 0.013948415693141 no 127 0.00400023184352944 19 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1450 4112-4260 37.6 µM 2.64705445240862 0.0140980801167724 no 128 0.0040598138727322 20 1633175 SGTC_321 4534-3890 65.3 µM 2.62774980405427 0.0146894884325953 no 129 0.00429758537688154 21 699746 SGTC_210 3551-0445 56.827 µM 2.62723634919942 0.0147055054821744 no 130 0.00430407603354718 31 2865180 YOR207C RET1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.625585907591 0.0147570922498739 no 131 0.00432499889898604 23 5024745 SGTC_2039 Aminomethylbenzodioxan 200 µM 2.61754365956891 0.0150106964256741 no 132 0.00442825788538316 18 15053 SGTC_2893 9048488 25.97 µM 2.61694425392912 0.0150297471882732 no 133 0.00443604147135399 30 6467338 SGTC_2760 etidronate 98.04 µM 2.60921288237456 0.0152773401259494 no 134 0.00453753831888049 23 3305 A chelator and antioxidant. SGTC_2871 9038510 12.99 µM 2.59456509352872 0.0157560426054546 no 135 0.00473553387083723 30 4945164 SGTC_681 1642-0006 26.6 µM 2.58651645874662 0.0160245148399833 no 136 0.0048475770011026 17 4446530 SGTC_433 pimozide 108 µM 2.58249093598517 0.016160255771763 no 137 0.00490449693892737 10 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.57920552694297 0.0162717690130255 no 138 0.00495139243588389 28 94937 An inhibitor of serotonin biosynthesis. SGTC_2883 9059145 45.46 µM 2.57054068836602 0.0165690369002527 no 139 0.00507699490235509 30 16476510 SGTC_2935 9038016 29.96 µM 2.56415490921774 0.0167910802414674 no 140 0.00517136859887848 25 6463195 SGTC_1860 st056228 74.6 µM 2.55798975025508 0.0170078621841927 no 141 0.00526395976433611 32 688679 SGTC_3294 9122953 26.2835 µM 2.55450927630226 0.0171312974126737 no 142 0.00531687981147384 29 16459826 SGTC_954 1189-0853 2.85 µM 2.5459952157296 0.0174364801322575 no 143 0.00544833408902321 24 2828194 SGTC_2887 9044784 58.44 µM 2.53696265232076 0.0177653113680217 no 144 0.00559094413038032 49 6465546 SGTC_441 propafenone 146 µM 2.52907516855573 0.0180567688808794 no 145 0.00571817655827128 18 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3033 9090887 49.47 µM 2.52850858287551 0.0180778613308769 no 146 0.00572741428358818 51 19325384 SGTC_1558 st069300 45.6 µM 2.5228965950964 0.0182879171465402 no 147 0.00581963105396057 25 24208000 SGTC_3055 9094636 49.47 µM 2.50484581325446 0.0189777114408561 no 148 0.00612523921035857 33 25236176 SGTC_3321 9137793 26.8275 µM 2.49047079617183 0.0195427536436717 no 149 0.00637869898190894 47 4904192 SGTC_814 3342-0569 96 µM 2.48858657548926 0.0196178657936768 no 150 0.0064126003469509 22 4346283 SGTC_1921 5740136 50 µM 2.4874762458675 0.019662242409194 no 151 0.00643265224449579 25 1774243 SGTC_1401 3807-4679 7.6 µM 2.46938079619527 0.0203975635434039 no 152 0.00676735520298089 26 3291456 SGTC_234 nsc-17383 10.7 µM 2.46613092067232 0.0205320633624302 no 153 0.00682907015231408 32 408974 SGTC_1180 1193-0155 285 µM 2.46418704605405 0.0206128714043563 no 154 0.00686622136247675 24 2921347 SGTC_1677 st019204 53.9 µM 2.4641508791774 0.0206143774323803 no 155 0.00686691426968966 26 3945625 SGTC_2677 mitomycin C 100 µM 2.44230727184872 0.0215411579978941 no 156 0.00729685973249902 19 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2684 capsaicin 100 µM 2.43466557156671 0.0218735872378706 no 157 0.00745277939561625 28 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1481 3346-2004 36 µM 2.42974560742462 0.0220898999543793 no 158 0.00755471190597005 18 2770522 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.42798231371085 0.0221678637410984 no 159 0.00759154183484959 30 6857784 SGTC_2471 5466956 24.79 µM 2.42373828908905 0.0223564652280439 no 160 0.00768083574883454 52 724419 SGTC_2909 7941780 10.49 µM 2.4130384956438 0.0228379727144684 no 161 0.00791007428485177 28 1243215 SGTC_1352 1496-0991 99 µM 2.40849658954004 0.0230449916948356 no 162 0.00800918797534605 17 3000039 SGTC_2822 7994718 71.43 µM 2.39784399844793 0.0235367411637789 no 163 0.00824594366179596 29 1018011 SGTC_2663 amphotericin b 100 µM 2.39474828635492 0.0236812913048054 no 164 0.0083158893456945 41 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1046 2001-0062 216 µM 2.39272468519737 0.0237761835700359 no 165 0.00836189245770542 28 739778 SGTC_1738 st035555 74 µM 2.37740697110759 0.0245048922719979 no 166 0.00871742010684389 39 5331140 SGTC_1092 toremifene 6.32 µM 2.37725835455174 0.0245120532030396 no 167 0.00872093347692689 30 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1633 st005664 67.9 µM 2.37403170943343 0.0246679592123846 no 168 0.0087975196870156 31 2063822 SGTC_1486 3970-0793 4.53 µM 2.3721567957839 0.0247589334309798 no 169 0.00884229208634051 31 2844330 SGTC_832 4083-0019 164 µM 2.32244932784493 0.0272754147405646 no 170 0.0101043769451656 73 1990758 SGTC_2565 isoliquiritigenin 100 µM 2.31187666244502 0.0278373129260619 no 171 0.0103922405740313 46 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2249 haloperidol 116.36 µM 2.29727003360738 0.028629437079783 no 172 0.0108016850755248 90 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3275 9138069 49.47 µM 2.28817397831116 0.0291321272425184 no 173 0.0110636957269411 31 17617007 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.28069205237123 0.0295510900073111 no 174 0.0112833378969506 31 688761 SGTC_3295 9122362 53.5725 µM 2.27806246312045 0.0296995208683383 no 175 0.0113614281515962 39 4730473 SGTC_2467 5474540 200 µM 2.27683339019252 0.0297691094753488 no 176 0.0113980883864276 45 5413519 SGTC_759 3486-0358 89.3 µM 2.27651474257604 0.0297871729797946 no 177 0.011407609624823 32 875103 SGTC_863 0466-0191 129 µM 2.27552386548242 0.0298434019587558 no 178 0.011437261346953 46 765160 YPR165W RHO1 SGTC_2634 4'-methoxyflavone 100 µM 2.27248128372914 0.0300166088663251 no 179 0.0115287285906627 33 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3274 9138298 49.47 µM 2.25604892646379 0.0309665305079551 no 180 0.012033783592561 37 17015756 SGTC_400 oxethazaine 37.5 µM 2.2435474862599 0.0317057621347838 no 181 0.0124307656417289 38 4621 A local anesthetic. SGTC_497 capsazepine 133 µM 2.24019530588387 0.0319064429289226 no 182 0.0125391231416706 33 2733484 A calcium channel blocker. SGTC_3192 9110362 49.47 µM 2.23885888290579 0.0319867408532947 no 183 0.0125825497725088 33 16649480 SGTC_1225 1216-0074 20.6 µM 2.23584075478174 0.0321686968178998 no 184 0.0126811021317587 25 4241466 SGTC_2276 7947513 42.08 µM 2.23183749236023 0.032411361688842 no 185 0.0128128526906158 30 2105100 SGTC_435 c-PAF 6.7 µM 2.23113643676385 0.0324540124332664 no 186 0.0128360464141739 43 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2714 st079313 56.9 µM 2.22658075265687 0.0327323000658859 no 187 0.0129876532505388 29 2939799 SGTC_347 4534-1311 26.2 µM 2.21482683514399 0.0334593944861731 no 188 0.0133859762757944 29 2862016 SGTC_54 0159-0055 9 µM 2.21283044125966 0.0335842022077081 no 189 0.0134546688614022 38 3319099 SGTC_868 0527-0199 213 µM 2.20377925776978 0.0341548670842631 no 190 0.013769936002314 36 2849450 SGTC_849 0386-0493 241 µM 2.19418134723609 0.0347686866607208 no 191 0.0141111874894056 36 726119 SGTC_3180 9109287 49.47 µM 2.19235066417279 0.0348867876748335 no 192 0.0141770980412567 57 18891271 SGTC_3337 9144342 33.5465 µM 2.19075042761197 0.0349902916828752 no 193 0.0142349288538084 45 17682949 SGTC_25 0118-0223 35.662 µM 2.18853665119709 0.0351338950906419 no 194 0.0143152672726598 31 5333628 SGTC_2873 9040596 71.43 µM 2.18362442081389 0.035454269343667 no 195 0.0144949287829417 59 6463863 SGTC_3068 9116768 49.47 µM 2.18076012698068 0.0356421807680563 no 196 0.0146005815897625 33 41904888 SGTC_1442 4112-3290 3 µM 2.17136495925281 0.0362642867948659 no 197 0.014951797749383 22 704353 SGTC_2664 lyso-paf C-16 73.48 µM 2.16773490173625 0.0365070214999284 no 198 0.0150894311762173 57 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1435 4092-0789 56.7 µM 2.16771855991578 0.0365081172433537 no 199 0.0150900532288147 47 2248285 SGTC_3104 9120930 49.47 µM 2.15482272320088 0.0373812291208965 no 200 0.0155878546846029 45 17014836 SGTC_1565 sinapyl alcohol 95.1 µM 2.15351935445482 0.0374704147847475 no 201 0.0156389423367499 37 5280507 A phenol propionate derived from cinnamic acid. SGTC_1049 3226-0134 66 µM 2.15296432584148 0.0375084464690157 no 202 0.015660741159594 43 5702385 SGTC_1933 st074711 15.9 µM 2.15208658442865 0.0375686554256305 no 203 0.0156952677822546 46 17250958 SGTC_2514 salinomycin 42.74 µM 2.14704922211741 0.0379157226525639 no 204 0.0158946815862113 45 23682228 A polyether potassium ionophore. SGTC_3074 9116018 49.47 µM 2.14252857632916 0.0382294120704309 no 205 0.0160754858367577 42 17027303 SGTC_1769 st044406 64.4 µM 2.14196261124099 0.0382688332498261 no 206 0.0160982454090562 70 670903 SGTC_1177 0983-0204 23.6 µM 2.141765096784 0.0382825985285352 no 207 0.0161061947010687 56 766818 SGTC_2000 st075254 36.4 µM 2.1409860769746 0.0383369297439415 no 208 0.0161375804310441 36 17234175 SGTC_418 lividomycin a 100 µM 2.14054116110149 0.0383679877262716 no 209 0.0161555290338744 29 72394 An antibiotic. SGTC_1356 1502-0781 85.8 µM 2.13204165815228 0.0389652564914743 no 210 0.0165017110395093 46 567702 SGTC_2060 5238662 140 µM 2.13114506496468 0.0390287000577266 no 211 0.0165385965457702 32 790130 SGTC_871 0574-0004 149 µM 2.12983166926612 0.0391217886761001 no 212 0.0165927565430652 77 9551173 SGTC_1899 st063254 59.6 µM 2.11831550272448 0.0399457748252765 no 213 0.0170741782838516 38 3093813 SGTC_1215 3852-0577 11.2 µM 2.10680121281171 0.0407836725283059 no 214 0.0175674071671603 40 2884876 SGTC_3196 9111891 49.47 µM 2.10077604716994 0.0412277764418284 no 215 0.0178303150194912 46 18891510 SGTC_991 3996-0057 64.7 µM 2.10076233343665 0.0412287917099305 no 216 0.0178309172250886 45 715343 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.09169685946827 0.0419043838188236 no 217 0.0182328208159712 47 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3102 9121669 49.47 µM 2.09021361112349 0.0420157693908083 no 218 0.0182993076981077 37 41905072 SGTC_1515 3460-0031 42.1 µM 2.08775948652316 0.0422005898073274 no 219 0.0184097679018242 52 2876596 SGTC_341 1486-1430 230 µM 2.0840881999216 0.0424783024798464 no 220 0.0185760726040123 77 2054753 YPL210C SRP72 SGTC_589 1227-0070 34.1 µM 2.0686023604787 0.0436660283097959 no 221 0.0192917081274487 49 2841384 SGTC_2603 homopterocarpin 100 µM 2.06658576875185 0.0438226491153334 no 222 0.0193866014666047 45 101795 A weak amylase inhibitor. SGTC_582 0987-0078 156 µM 2.05889885886172 0.0444238218816046 no 223 0.0197519642184553 55 1625765 SGTC_3208 9114115 49.47 µM 2.05018476248879 0.0451133459297137 no 224 0.0201732021780166 81 650895 SGTC_2206 7254556 146.969 µM 2.04959749272562 0.045160123135329 no 225 0.0202018626523326 27 4398905 SGTC_260 nsc-65238 3.989 µM 2.04178385774549 0.0457862162389288 no 226 0.0205864880856264 42 3246252 SGTC_2964 9083345 53.42 µM 2.03865682848576 0.0460387262013756 no 227 0.0207421446306458 68 17741579 SGTC_980 1473-0395 201 µM 2.03570351901518 0.046278234187625 no 228 0.0208900677620445 48 768876 SGTC_1934 st074720 32.6 µM 2.03323680735265 0.0464790458822312 no 229 0.0210143020338773 60 17250992 SGTC_2802 7925815 54.55 µM 2.03304508384084 0.0464946830845202 no 230 0.0210239841909132 57 1262923 SGTC_3041 9091929 49.47 µM 2.03278390582772 0.0465159918740899 no 231 0.0210371799173387 44 25236887 SGTC_1300 1094-0077 113 µM 2.02829749655532 0.046883250735481 no 232 0.0212649471642351 45 5532636 SGTC_1484 3473-2379 286 µM 2.02650255693202 0.0470308348640055 no 233 0.0213566554850268 29 671917 SGTC_1185 1319-0113 81.3 µM 2.02567434439064 0.0470990579155301 no 234 0.0213990837244435 43 4672763 SGTC_2540 epiandrosterone 100 µM 2.02015419589111 0.0475558028144214 no 235 0.0216836978625853 58 441302 A steroid. SGTC_2050 5263056 171 µM 2.01984878567758 0.047581176108279 no 236 0.0216995374811048 78 763468 YGL055W OLE1 SGTC_916 4466-0038 42 nM 2.0060403944634 0.0487397418581888 no 237 0.0224259692035231 86 5722064 YGL116W CDC20 SGTC_69 0096-0274 206.684 µM 2.00199129047431 0.0490837162791391 no 238 0.0226428341247973 114 6741392 SGTC_1762 st045503 25.4615 µM 2.00092118144256 0.0491749460508459 no 239 0.0227004422660605 41 4645554 SGTC_1103 duloxetine 36.1 µM 1.99958363169632 0.0492891662476161 no 240 0.0227726214372815 67 60835 A selective serotonin reuptake inhibitor. SGTC_1806 st050005 60.3 µM 1.99100609939491 0.0500266888962778 no 241 0.0232401083462773 52 5194765 SGTC_1714 st033236 13.627 µM 1.98448865364923 0.0505929410090888 no 242 0.0236006958639996 44 2916566 SGTC_1048 3161-0300 24.5 µM 1.98433408016894 0.0506064324655797 no 243 0.0236093046801938 40 2165101 SGTC_1500 4488-1866 171 µM 1.9840941619671 0.0506273786413944 no 244 0.0236226719166754 43 2900003 SGTC_1873 rapamycin 2 nM 1.9794613482875 0.051033204400732 no 245 0.0238820436296652 54 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_172 1112-0046 2.638 µM 1.97877063814431 0.0510939304828967 no 246 0.0239209178661032 46 2802135 YIL048W NEO1 SGTC_2047 4141938 200 µM 1.97849130843593 0.0511185050088606 no 247 0.0239366540701298 40 3807862 SGTC_1216 1165-0504 9.65 µM 1.96549711009737 0.0522721253598227 no 248 0.0246783649107482 52 6304004 SGTC_3355 9151058 44.0485 µM 1.96506702708339 0.052310658562846 no 249 0.0247032401507208 49 17015728 SGTC_2051 5263410 176 µM 1.96423511512809 0.0523852575583249 no 250 0.0247514161639302 55 227584 SGTC_1126 isoteolin 1.0172 µM 1.95978139280244 0.0527860681231218 no 251 0.0250106734965567 48 133323 SGTC_2044 5102272 200 µM 1.95802143074705 0.0529451241672894 no 252 0.0251137490235002 57 592666 SGTC_2274 7947094 46.08 µM 1.95614423871555 0.0531151935356021 no 253 0.0252240825249444 52 2971028 SGTC_757 1066-0008 322 µM 1.95547385894051 0.0531760332906925 no 254 0.0252635829480018 51 6842497 SGTC_2975 9084847 53.72 µM 1.95415291906835 0.0532960757587033 no 255 0.0253415676567338 58 27211724 SGTC_1892 st058411 7.36 µM 1.95275460584177 0.053423383580309 no 256 0.0254243399055705 47 3934738 SGTC_287 k060-0039 29.6 µM 1.95151791305302 0.0535361775565473 no 257 0.0254977337191111 64 5861974 SGTC_2543 pimpinellin 60.67 µM 1.9503437241626 0.0536434453274481 no 258 0.0255675822449412 52 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2451 5856223 45.7 µM 1.94205613172742 0.0544054055209166 no 259 0.0260651526940982 78 2179896 SGTC_896 0964-0007 44.5 µM 1.94192257485678 0.0544177544549591 no 260 0.0260732370233631 60 6756758 SGTC_548 1436-0017 110 µM 1.93128152202618 0.0554087931345797 no 261 0.0267241236044459 57 9677137 SGTC_2796 7949634 45.45 µM 1.93088157050256 0.0554463180835051 no 262 0.0267488498898612 63 2971588 SGTC_2497 7-hydroxyflavone 100 µM 1.93084101128261 0.055450124621625 no 263 0.0267513584575084 65 5281894 SGTC_2367 9070478 135.38 µM 1.93068025506607 0.0554652138413958 no 264 0.0267613030823961 64 572802 SGTC_1439 4092-1168 46 µM 1.92937093678511 0.0555882324370821 no 265 0.0268424145332575 48 2886240 SGTC_2189 6047310 154.431 µM 1.92233770753819 0.0562527376948919 no 266 0.0272816391100347 51 711535 SGTC_1998 st075797 76.8 µM 1.90610477129384 0.0578103447991628 no 267 0.0283183069002363 56 24208315 SGTC_3085 9117376 49.47 µM 1.9036895501307 0.0580449640735719 no 268 0.0284753140980248 57 16480349 SGTC_652 0437-0092 114 µM 1.9000439686143 0.0584005193201435 no 269 0.028713674900056 52 3091274 SGTC_189 3970-0742 2.116 µM 1.89151814325927 0.0592387244112154 no 270 0.0292776056896777 42 2891807 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.88458386907291 0.0599273907641116 no 271 0.0297430209183738 49 5357218 A potent inhibitor of glutathione S-transferases. SGTC_752 1896-0090 130 µM 1.88078871824971 0.0603069463152876 no 272 0.0300003327199733 59 772567 SGTC_2072 5231554 129 µM 1.88062515184539 0.0603233468961089 no 273 0.0300114639116937 55 789545 SGTC_1160 4092-0570 10.5 µM 1.87939113444378 0.0604471926793814 no 274 0.0300955529842512 63 4994975 SGTC_951 1171-0579 82.7 µM 1.87793435072138 0.0605936512234835 no 275 0.0301950732396295 79 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2513 baicalein 25.65 µM 1.87120928411654 0.0612733610314341 no 276 0.0306580392147147 58 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2097 5376186 200 µM 1.86857487637993 0.0615412417980852 no 277 0.0308409919167558 57 742755 SGTC_1354 1498-1681 81 µM 1.86691162507304 0.0617108406003938 no 278 0.0309569650915607 72 5754243 SGTC_1205 4161-2785 76 µM 1.85324721542968 0.0631180225798728 no 279 0.0319234665180737 56 3498106 SGTC_1034 k072-0165 12.7 µM 1.85083125802999 0.063369401193888 no 280 0.0320969163348234 60 5835461 SGTC_3317 9138495 8.753 µM 1.85078669243421 0.063374045521654 no 281 0.0321001231449143 77 17020139 SGTC_270 tamoxifen 5.46 µM 1.84513255192116 0.0639654343625833 no 282 0.0325091294987431 73 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1931 st074438 57.1 µM 1.83343110803116 0.0652029567126442 no 283 0.0333692424844342 90 2787313 SGTC_2067 5224629 34.075 µM 1.82244401585269 0.066381765315907 no 284 0.0341938205357863 69 2835000 SGTC_1833 st055984 71 µM 1.82242465039857 0.0663838575135976 no 285 0.0341952885619916 48 676288 SGTC_2331 7980721 200 µM 1.81937882408942 0.0667135573439652 no 286 0.0344268275566487 88 2981221 SGTC_3103 9120822 49.47 µM 1.81746528803527 0.0669213380153395 no 287 0.0345729493651116 85 17141819 SGTC_924 2046-0044 21.3 µM 1.8169056254838 0.0669822033082048 no 288 0.0346157825872706 71 3623589 SGTC_947 3447-0010 211 µM 1.81681232612998 0.0669923541074357 no 289 0.0346229273984252 76 748350 SGTC_2529 gangaleoidin 93.61 µM 1.81645142061968 0.0670316311711006 no 290 0.0346505767417283 46 4565183 SGTC_2924 9010168 62.78 µM 1.81007652271846 0.067728345720269 no 291 0.0351419605846537 54 2993929 SGTC_128 0906-2981 13.371 µM 1.80653605024168 0.0681176938287728 no 292 0.0354173241567269 80 6740226 SGTC_3023 9089636 49.47 µM 1.80571803625438 0.0682078966122528 no 293 0.0354811969510981 51 17249241 SGTC_2585 alliin 100 µM 1.80404032920063 0.0683931865610467 no 294 0.0356124924619377 63 87310 A garlic compound which reacts with lipids. SGTC_2199 6590217 200 µM 1.80072722667124 0.0687602339270472 no 295 0.0358729420189007 59 703109 SGTC_1253 0550-0034 176 µM 1.7962776779184 0.0692555717411638 no 296 0.0362251830683892 80 5969915 SGTC_3122 9126309 49.47 µM 1.79493204680008 0.069405911768913 no 297 0.0363322636487664 75 17591206 SGTC_1316 1272-0050 65.9 µM 1.78898519854321 0.0700733323836838 no 298 0.0368085996669507 62 7340392 SGTC_1621 st003705 32.4 µM 1.78795651027154 0.0701892823273803 no 299 0.0368915122894385 71 24207032 SGTC_3140 9094243 49.47 µM 1.78552393187158 0.0704640606244048 no 300 0.0370881865267517 70 19291112 SGTC_1072 oxiconazole 14.9 nM 1.78418813542616 0.0706153003655217 no 301 0.0371965497844201 88 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1028 k015-0029 4.8 µM 1.78385414936449 0.0706531534437694 no 302 0.0372236839869816 78 4588309 SGTC_1136 pergolide 1.05886 µM 1.78013435774495 0.0710757992583817 no 303 0.0375269874676569 97 47811 A dopamine receptor agonist. SGTC_2790 5423970 71.43 µM 1.77921217897292 0.0711808777101537 no 304 0.0376024912062792 82 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_411 enrofloxacin 100 µM 1.77920048747432 0.0711822106732749 no 305 0.0376034492478017 55 71188 A bacterial gyrase inhibitor. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.77781000915737 0.0713408776588411 no 306 0.0377175320205594 78 5393153 SGTC_2915 7971052 15.16 µM 1.7709590766795 0.0721266017280952 no 307 0.0382837535890821 45 5741558 SGTC_2702 st077768 96.8 µM 1.75741902908659 0.0736989797222681 no 308 0.0394232060823028 51 6484119 SGTC_3070 9117005 49.47 µM 1.75577022423383 0.0738922281571769 no 309 0.0395638252551562 35 8779016 SGTC_853 0419-0306 21 µM 1.75394082967809 0.0741070955419135 no 310 0.0397203232416065 91 762713 SGTC_2400 5203494 178.7 µM 1.7479229108874 0.0748172846069128 no 311 0.0402386885070879 90 6777674 SGTC_3031 9088762 49.47 µM 1.74737772846805 0.0748818785356789 no 312 0.0402859190663629 69 205253 SGTC_594 1487-1584 10.8 µM 1.74465275959485 0.0752053743225102 no 313 0.0405226655238289 78 5013332 SGTC_1992 st073643 23.3 µM 1.74208068637698 0.0755116955244176 no 314 0.0407471633032173 67 3161292 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.73521759797455 0.0763337081663837 no 315 0.041351135304241 79 688662 SGTC_1146 3579-1023 7 µM 1.73310820800248 0.0765877192569911 no 316 0.0415382188758094 79 X1146 SGTC_12 0849-0099 9.267 µM 1.72735269343555 0.077284063860555 no 317 0.0420521705498179 78 6071388 SGTC_2734 clemastine 41.6 µM 1.72300402285926 0.0778133801488772 no 318 0.0424438987776489 73 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2869 9037858 32.47 µM 1.71967357915238 0.0782206158705727 no 319 0.0427458965253796 55 27187042 SGTC_1190 1486-1332 13 µM 1.70842720430739 0.0796077346434019 no 320 0.0437785515173662 70 4150046 SGTC_2018 5133068 143 µM 1.70740149134955 0.0797351655611777 no 321 0.0438737266846077 79 785362 SGTC_1003 4049-0218 100 µM 1.7020262525248 0.0804054902792337 no 322 0.0443752235482275 100 295161 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.6933015887908 0.0815025599490353 no 323 0.0451990379369054 65 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1308 1187-1617 41.4 µM 1.69323336042182 0.0815111834840236 no 324 0.045205528469185 85 2882570 SGTC_1331 1472-0049 76.2 µM 1.68892165023218 0.0820575468903024 no 325 0.045617222834793 86 24051409 SGTC_2113 5491891 107.031 µM 1.68693608593048 0.0823100759088377 no 326 0.045807821173372 87 789979 SGTC_2624 nerol 100 µM 1.68623462574378 0.0823994291231572 no 327 0.0458753085499518 71 637566 A natural product oil. SGTC_2512 diallyl trisulfide 49.23 µM 1.68583526926995 0.0824503324589818 no 328 0.0459137662521479 81 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_215 1287-0124 461.5 µM 1.68288886239739 0.0828266234441117 no 329 0.0461983040336915 48 5560863 SGTC_408 cantharidin 100 µM 1.68283613980532 0.0828333684899619 no 330 0.0462034083801516 70 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_792 4534-1957 155 µM 1.68209875557815 0.0829277487910041 no 331 0.0462748458305907 66 1717904 SGTC_2428 5615643 7.78 µM 1.68165248990442 0.082984907124343 no 332 0.0463181229091997 103 2253075 SGTC_2853 9015042 58.44 µM 1.67701578428063 0.0835805373916363 no 333 0.0467696976614848 55 6457456 SGTC_3046 9092212 49.47 µM 1.67404645307272 0.083963660876462 no 334 0.0470607350930989 62 25236637 SGTC_2549 cedrol 20.94 µM 1.67229171854691 0.0841906878428902 no 335 0.0472334059394427 98 6708665 A sedative which affects the nervous system. SGTC_1349 flufenamic acid 69 µM 1.6635054433224 0.0853343870166804 no 336 0.0481056510806537 79 3371 A non-steroidal anti-inflammatory. SGTC_907 3448-6986 75.5 µM 1.66093546366655 0.0856711084328117 no 337 0.0483632044081671 86 590582 SGTC_1504 k297-0033 30 µM 1.66042511462555 0.0857380931191813 no 338 0.0484144806160297 46 4388117 SGTC_2466 5983409 37.09 µM 1.65821827722918 0.0860281978434386 no 339 0.0486367084877291 85 2879657 SGTC_3273 9137859 49.47 µM 1.65706528355986 0.0861800589947081 no 340 0.0487531385137091 85 2377234 SGTC_555 4296-0685 37 µM 1.65423674755901 0.0865534555794561 no 341 0.0490397095490193 85 2908540 YHR072W ERG7 SGTC_1024 4507-0395 26 µM 1.65249559205791 0.0867839070609987 no 342 0.0492167814894207 77 4201836 SGTC_1520 flindersine 88 µM 1.64672383641089 0.0875511096972016 no 343 0.0498074112367772 86 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2158 5657123 3.6195 µM 1.64642280895464 0.0875912617837628 no 344 0.049838370154695 87 2858827 SGTC_841 0251-0215 91.2 µM 1.64081847160263 0.0883412989272077 no 345 0.0504175513610858 80 3888614 SGTC_2963 9082507 9 µM 1.6381900765439 0.0886947053936088 no 346 0.0506910245302843 89 16459611 SGTC_703 3875-0075 71.8 µM 1.63352052094523 0.0893251556728854 no 347 0.051179784199931 90 2850814 SGTC_2865 9030313 51.95 µM 1.63096922439155 0.0896710189390497 no 348 0.0514484067453475 62 42562754 SGTC_1061 3448-9325 110 µM 1.62900193145328 0.0899383916421663 no 349 0.051656305036566 96 723482 SGTC_2082 5219693 150 µM 1.62886737148199 0.0899567011700252 no 350 0.0516705493447543 74 2834649 SGTC_979 1426-2828 121 µM 1.62611742609613 0.0903314922466065 no 351 0.0519623388188215 83 747872 SGTC_1396 3511-0007 98.6 µM 1.62295983548808 0.0907632702493792 no 352 0.0522989955523028 83 X1396 SGTC_1683 st010134 710 nM 1.62071970988195 0.0910705188759838 no 353 0.0525388822936727 81 3818134 SGTC_840 0245-0196 390 µM 1.61925560627381 0.09127174719128 no 354 0.0526961390827329 87 3827528 SGTC_2733 amorolfine 100 µM 1.61235624666322 0.0922244426128726 no 355 0.0534422200592216 73 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_517 1365-0151 113 µM 1.60954592026191 0.0926146081578667 no 356 0.0537485112360314 81 768657 SGTC_870 0573-2213 57.6 µM 1.60618667940308 0.0930825814166293 no 357 0.0541164496186606 78 3916321 SGTC_3346 9158254 43.5805 µM 1.60468391922486 0.0932924946634818 no 358 0.0542816913070105 98 17639500 SGTC_961 1252-1571 372 µM 1.59214817224421 0.0950571951096754 no 359 0.0556757076578626 100 6813498 SGTC_48 0382-0018 55 µM 1.58902180662442 0.09550111055489 no 360 0.056027734789317 59 762596 SGTC_2168 5727979 200 µM 1.58228523214273 0.0964628251335509 no 361 0.0567922352484722 94 695210 SGTC_997 3996-0078 137 µM 1.58102122718463 0.0966440648030806 no 362 0.056936592132463 90 735687 SGTC_484 loperamide 105 µM 1.57612722855374 0.0973481511403439 no 363 0.0574982425499786 38 3955 An opioid-receptor agonist. SGTC_883 0850-0245 24.6 µM 1.57582098928891 0.0973923337341514 no 364 0.0575335318917042 110 6823229 YPR165W RHO1 SGTC_469 w7 172 µM 1.56938654954632 0.0983240651296529 no 365 0.0582789481157281 63 45115570 A P450 inhibitor. SGTC_223 busulfan 5 mM 1.56926066983691 0.0983423578720141 no 366 0.0582936063161637 75 2478 A DNA alkylator. SGTC_1863 st057641 20.1 µM 1.56487577840195 0.0989811233533506 no 367 0.0588060195360944 95 3921635 SGTC_1859 st055998 20 µM 1.56481722652347 0.0989896733369399 no 368 0.0588128856779248 87 676301 SGTC_268 camptothecin 39.6153 µM 1.56401988365149 0.0991061583652619 no 369 0.0589064494807666 144 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2370 9071495 200 µM 1.56170284929651 0.0994452263198351 no 370 0.0591790036323442 97 21791103 SGTC_679 0422-0091 41.4 µM 1.56093963479659 0.0995570983108659 no 371 0.0592689972371474 102 627384 YHR062C RPP1 SGTC_1090 efavirenz 20.7 µM 1.56047258199242 0.0996256042640245 no 372 0.0593241221649326 85 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_155 k072-0202 43.6 µM 1.5569005558245 0.100150678120595 no 373 0.0597470487408313 99 5857737 SGTC_2256 7954252 200 µM 1.551954724131 0.100881027164178 no 374 0.0603365286775449 97 2972920 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.55066412500409 0.101072246736437 no 375 0.0604910980376064 85 2724 A muscle relaxant with antifungal properties. SGTC_2719 novobiocin 32.65 µM 1.55020688113131 0.101140056888082 no 376 0.0605459343846587 76 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_583 1488-1091 88.9 µM 1.53962572435662 0.1027185352308 no 377 0.0618258056529774 113 4303273 SGTC_672 1441-0018 53.7 µM 1.53599498978547 0.103264266263711 no 378 0.0622698045762125 72 251141 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.53583527958885 0.103288320343658 no 379 0.062289392333043 106 65057 A dermal irritant. YDR527W RBA50 SGTC_70 0141-0289 43.283 µM 1.52805671032421 0.104464785486486 no 380 0.0632492291596327 104 352408 SGTC_2720 fluspirilene 36.88 µM 1.5280510106207 0.104465651079822 no 381 0.0632499366730558 79 3396 An atypical antipsychotic. SGTC_1037 k284-1091 78.7 µM 1.52438929183923 0.105022817629163 no 382 0.0637057467218395 90 3334711 SGTC_1726 st035556 14.5795 µM 1.52418532016779 0.105053917051612 no 383 0.0637312120205919 75 5919439 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.52297935890695 0.105237925360499 no 384 0.0638819347965951 90 6708514 SGTC_2414 st077232 92.9 µM 1.52258286572056 0.10529847410222 no 385 0.0639315495964782 82 729801 SGTC_508 roscovitine 141 µM 1.52011414310056 0.105676041471908 no 386 0.0642411453119241 99 160355 A CDKinase inhibitor. SGTC_3268 9137683 49.47 µM 1.51649976489005 0.106230589940483 no 387 0.0646965148637783 107 1953228 SGTC_2005 4024620 188 µM 1.51609017320527 0.10629356531016 no 388 0.0647482763846022 98 236743 SGTC_2036 5160441 105 µM 1.51578221471859 0.106340932168809 no 389 0.0647872153406468 126 134534 YIL048W NEO1 SGTC_2437 5741531 144.16 µM 1.51559307353636 0.106370031383912 no 390 0.064811139784306 114 2262990 SGTC_747 3448-8087 38.7 µM 1.5154080293776 0.106398505839491 no 391 0.0648345526339222 94 5168703 SGTC_708 3448-5400 146 µM 1.51531373861927 0.10641301734695 no 392 0.0648464853675018 134 3462195 SGTC_2944 9067346 25.62 µM 1.51275997429088 0.106806589657862 no 393 0.0651703196054019 108 6473075 SGTC_1730 st033808 45.1 µM 1.50934955647102 0.107333821188077 no 394 0.0656047383539396 87 1045166 SGTC_860 0443-0016 25.1 µM 1.50731800413791 0.107648778144124 no 395 0.0658645824356954 124 5337942 SGTC_365 0121-0052 13.6 µM 1.4975622057798 0.109170523126494 no 396 0.0671235161825091 90 3101739 SGTC_378 3970-0959 8.33 µM 1.49407513288219 0.109718181874926 no 397 0.0675779913612966 108 6615653 SGTC_3044 9093193 49.47 µM 1.49272987833507 0.109929985801651 no 398 0.0677539545056765 93 25236277 SGTC_1102 cgs 12066b 26.1 µM 1.49175239788659 0.110084069391334 no 399 0.0678820336001436 90 6438352 A 5-HT1B full agonist. SGTC_1200 1643-0193 18.4 µM 1.49123873296789 0.110165102226698 no 400 0.0679494139286333 106 5403974 SGTC_209 4077-0173 175.592 µM 1.48871190762582 0.110564342649792 no 401 0.0682816240126924 75 15993494 SGTC_1478 0453-0656 35.7 µM 1.48771466272349 0.110722193221342 no 402 0.0684130795276509 101 5258496 SGTC_2977 9011197 71.43 µM 1.4874172371267 0.110769302977425 no 403 0.0684523235581104 96 2704722 SGTC_1249 0481-0015 10.2 µM 1.48692003810103 0.11084808726265 no 404 0.0685179656149528 114 4227577 SGTC_1925 st057770 10.1 µM 1.48449264320048 0.111233299566146 no 405 0.0688391367145775 86 5989122 SGTC_2040 5100729 123 µM 1.48301005939802 0.111469047228229 no 406 0.0690358690689339 100 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2059 5238311 157 µM 1.47965313575885 0.112004157092929 no 407 0.0694829191500232 102 703021 SGTC_663 1486-0733 13.9 µM 1.47774720969271 0.112308787080813 no 408 0.0697377265178445 102 722445 YPR165W RHO1 SGTC_923 1900-2434 73.3 µM 1.47739511621053 0.112365127987117 no 409 0.0697848772679013 124 5910570 SGTC_2785 7756463 72.73 µM 1.4707576211775 0.113431020189003 no 410 0.0706783385195409 136 2201551 SGTC_999 SEC7.066 22.7 µM 1.46640257251117 0.114134288471966 no 411 0.0712693229629292 113 740511 YDR170C SEC7 SGTC_1539 benzyladenosine 56 µM 1.45861609300228 0.115399405290382 no 412 0.0723354008662448 100 92208 A nucleotide analog. SGTC_1128 3448-9350 235 µM 1.45603439746235 0.115821060860774 no 413 0.0726915554967064 87 619386 SGTC_1107 amlodipine 47 µM 1.45577387508839 0.11586367138772 no 414 0.0727275700022471 99 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2292 7671323 168.05 µM 1.45560568183048 0.115891186658485 no 415 0.0727508282256804 138 937504 SGTC_2365 9042475 200 µM 1.45243343344717 0.11641101406246 no 416 0.0731905628338158 95 6464479 SGTC_343 4130-2827 29.8 µM 1.45235884509417 0.116423256516789 no 417 0.0732009266296545 90 1118244 SGTC_1606 st000094 49.2 µM 1.44983079359907 0.116838734871342 no 418 0.0735528550483068 111 1242210 SGTC_2851 9015922 71.43 µM 1.44615830789408 0.117444168528085 no 419 0.0740664022718485 120 2996893 SGTC_173 1273-0061 2.693 µM 1.44594536245031 0.117479342010795 no 420 0.0740962636072796 139 2847414 YPL266W DIM1 SGTC_1150 3909-7983 10.9 µM 1.44405672988692 0.11779162528575 no 421 0.0743615091442347 128 23965914 SGTC_1441 4106-0040 13 µM 1.44338387321522 0.117903023173714 no 422 0.0744561822220325 96 2904180 SGTC_1782 st039423 80.636 µM 1.44336281465505 0.117906510823204 no 423 0.074459146712884 98 2068169 SGTC_1226 3909-7979 35.4 µM 1.44121663453034 0.118262336974745 no 424 0.0747617451704396 123 6615510 SGTC_170 4197-0004 226 µM 1.4410143855844 0.118295907963567 no 425 0.0747903093610343 115 218692 SGTC_1060 3448-7350 82 µM 1.44036144625166 0.118404334335917 no 426 0.0748825826651243 109 570178 SGTC_1838 st055369 84.5 µM 1.44029356510922 0.118415610632141 no 427 0.0748921806011274 94 676036 SGTC_3200 9114385 49.47 µM 1.43989096292629 0.118482505802349 no 428 0.0749491251259322 103 17018030 YLR208W SEC13 SGTC_1942 st076330 65.2 µM 1.43972025518288 0.118510878150472 no 429 0.0749732801975668 102 24208414 SGTC_1027 k015-0025 8.67 µM 1.43661053123992 0.11902856802303 no 430 0.0754143447689303 106 3598955 SGTC_627 1391-0720 175 µM 1.43353775637908 0.119541673192516 no 431 0.0758521084747116 123 997839 SGTC_1971 st069429 63.5 µM 1.42855372203709 0.120377242999645 no 432 0.0765662717038318 79 1246522 YGL099W LSG1 SGTC_2641 levomentholum 100 µM 1.42643816925355 0.120733154728833 no 433 0.0768709513071696 92 16666 SGTC_1767 st044992 70.3 µM 1.42617113063552 0.120778132782978 no 434 0.0769094753400577 97 9600693 SGTC_1640 st009078 66.4 µM 1.42533328492898 0.120919330005448 no 435 0.0770304414932116 108 690618 SGTC_3198 9112019 49.47 µM 1.41942006339295 0.121919153667965 no 436 0.077888293258557 117 45595555 SGTC_2775 cyproheptadine 69.59 µM 1.41698150378938 0.122333158496307 no 437 0.07824416763864 100 2913 A selective serotonin reuptake inhibitor. SGTC_2299 7976368 114.88 µM 1.41621132332604 0.122464120176023 no 438 0.0783568207907115 95 2979718 SGTC_2431 5490079 200 µM 1.41421163998137 0.122804606061241 no 439 0.0786498856608559 137 5722345 SGTC_471 1-acyl-paf 4 µM 1.41369502243317 0.122892678290044 no 440 0.078725733735005 97 16759367 SGTC_776 4476-4378 112 µM 1.41236659517395 0.12311935002483 no 441 0.0789210235168863 100 2892008 SGTC_1686 st019653 115.5 µM 1.41205506229319 0.123172549786064 no 442 0.0789668745003143 115 97252 SGTC_2481 5478948 45.16 µM 1.40801065733339 0.123864666084381 no 443 0.079563957135359 103 77792 SGTC_1947 st076332 61.6 µM 1.40449487941762 0.124468526708082 no 444 0.0800857677103682 110 24208416 SGTC_2774 tamoxifen 10.92 µM 1.40183054698529 0.124927514229279 no 445 0.0804829271313594 99 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2031 5180455 200 µM 1.39441194703879 0.126211750036555 no 446 0.0815966212209529 104 29949 SGTC_2234 tolnaftate 200 µM 1.39205243166992 0.126622128344013 no 447 0.0819532606408764 99 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1430 4049-0248 69.1 µM 1.39048975953929 0.126894426848862 no 448 0.0821901034030965 117 22774488 SGTC_921 1561-0023 372 µM 1.3896544765237 0.127040143516662 no 449 0.082316912382565 126 24050882 SGTC_1602 st001878 87.6 µM 1.3893606655903 0.127091427052305 no 450 0.0823615524711233 130 595405 YLR310C CDC25 SGTC_27 0485-0001 32.618 µM 1.38778891144192 0.127366015179503 no 451 0.0826006661678372 99 2054479 SGTC_1973 st070275 50.2 µM 1.38746637017187 0.127422414677324 no 452 0.0826497994835875 76 17118334 SGTC_3334 9142812 21.919 µM 1.3868875286372 0.127523674334695 no 453 0.0827380306523025 108 45283678 SGTC_1665 st014639 11.4 µM 1.38328549862746 0.128155052937568 no 454 0.0832886713445809 117 981133 YIL048W NEO1 SGTC_1871 st057448 67.3 µM 1.38242461183585 0.128306273615783 no 455 0.0834206817111453 109 691747 SGTC_3264 9137442 49.47 µM 1.38022435652482 0.128693326405469 no 456 0.0837587884590242 108 17015726 SGTC_3134 9127454 49.47 µM 1.38019619105263 0.128698286314946 no 457 0.0837631232270809 87 24262820 SGTC_1814 st052110 31.539 µM 1.37928888960137 0.12885813208483 no 458 0.0839028503662256 110 674163 SGTC_1197 1601-0112 267 µM 1.37680278371982 0.129296832550876 no 459 0.0842866149865108 117 7350313 SGTC_2940 9060638 45.86 µM 1.37128950094962 0.130273401520005 no 460 0.0851423636363263 105 4027022 SGTC_838 0109-0203 71.4 µM 1.3691712085566 0.130649968658617 no 461 0.0854728817902435 106 759422 SGTC_2129 girgensonine 121.053 µM 1.36862773558442 0.130746702599773 no 462 0.0855578348249864 142 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1945 st075991 56.6 µM 1.36729430429758 0.130984252663782 no 463 0.0857665381339696 114 1084980 SGTC_1295 1013-0063 9.78 µM 1.36505443299072 0.131383955384582 no 464 0.0861179711531703 114 6826038 SGTC_788 1182-0090 188 µM 1.36448418198238 0.131485850439611 no 465 0.0862076146337466 118 5715185 SGTC_758 0868-0029 16 µM 1.35948502103486 0.132381458810993 no 466 0.0869964729229325 102 762687 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.3589437831596 0.132478674145266 no 467 0.0870822016915778 106 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3252 9135871 49.47 µM 1.35658268118939 0.132903342684623 no 468 0.087456923868919 107 17682838 SGTC_3228 9131799 49.47 µM 1.3525754587256 0.133626226300983 no 469 0.0880956485004318 117 17015818 SGTC_2690 usnic acid 100 µM 1.34987584344474 0.134114745385413 no 470 0.0885279057476805 115 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1420 4'-methoxyflavone 42 µM 1.34934905681005 0.134210214936853 no 471 0.0886124377503368 99 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1754 st042065 16.137 µM 1.34836679055962 0.134388355711686 no 472 0.0887702198638632 142 1126236 YIL048W NEO1 SGTC_191 3914-0123 66.505 µM 1.34746461396694 0.1345521146525 no 473 0.0889153213503242 123 3144412 SGTC_2644 guaiazulene 100 µM 1.34335149253058 0.135300444963705 no 474 0.0895790929512429 92 3515 A coloring agent. SGTC_2427 5545055 42.75 µM 1.33958718841392 0.135987808250398 no 475 0.0901897956361875 122 5372858 SGTC_1022 4477-0945 21.3 µM 1.33882224658803 0.136127778651383 no 476 0.0903142733425854 105 4648966 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.33870175504318 0.136149835392366 no 477 0.0903338923566855 131 688803 SGTC_2296 7971656 126.45 µM 1.3376742413505 0.136338027651836 no 478 0.0905013256821033 94 666570 SGTC_2815 7968870 71.43 µM 1.33763007159488 0.136346121464683 no 479 0.0905085283040132 114 2977326 YHR190W ERG9 SGTC_509 pifithrin 175 µM 1.33497713374228 0.136832857507762 no 480 0.0909419152490683 115 4817 A p53 inhibitor. SGTC_2146 5545642 200 µM 1.33327641115149 0.137145514087526 no 481 0.0912205558914439 124 825326 SGTC_3027 9089541 49.47 µM 1.3306579360237 0.137627841482624 no 482 0.0916507948737984 129 9943819 SGTC_2546 rhodinyl acetate 100 µM 1.33034028776433 0.137686431458178 no 483 0.091703089425656 134 6708682 SGTC_911 3456-4043 236 µM 1.32856699824908 0.138013826077018 no 484 0.0919954329771269 117 914281 SGTC_2773 thioridazine 9.09 µM 1.32672521457242 0.138354428166351 no 485 0.0922997984684026 107 5452 An antipsychotic. SGTC_815 1582-0027 36.9 µM 1.3263258811253 0.138428352639118 no 486 0.0923658888505871 128 3128206 SGTC_2495 cafestol 54.53 µM 1.32174338704336 0.139278589286456 no 487 0.0931268078844793 152 16667697 An anti-infammatory. SGTC_611 3453-1652 23.7 µM 1.31966683584254 0.139665040423581 no 488 0.0934731386627222 147 1560575 SGTC_678 1218-2179 85.9 µM 1.31945568550465 0.139704376803029 no 489 0.0935084078919126 127 6820081 YOR116C RPO31 SGTC_3152 9099253 49.47 µM 1.31786942890492 0.140000130275633 no 490 0.0937736805655199 156 25236131 SGTC_1429 4049-0205 9.46 µM 1.31760558142827 0.140049365199119 no 491 0.0938178581092196 107 22774478 SGTC_2035 5154463 94.595 µM 1.31645129837328 0.140264897028791 no 492 0.0940113071747209 147 2769623 SGTC_1459 k035-0031 35.7 µM 1.31640760270323 0.140273060462502 no 493 0.0940186360145871 106 3877128 YMR208W ERG12 SGTC_688 0527-0193 473 µM 1.31638138111809 0.140277959459155 no 494 0.094023034222518 121 4007154 SGTC_1393 3470-5649 58.2 µM 1.31525293586544 0.140488897764274 no 495 0.094212454869997 84 4108395 SGTC_1727 st034309 9.9045 µM 1.30943051186015 0.141580694328039 no 496 0.0951942808046123 155 870305 SGTC_901 1112-0062 60.1 µM 1.30538192687668 0.142343247639791 no 497 0.0958814146864992 115 1908457 SGTC_2194 5927483 104.545 µM 1.30283498537551 0.142824386821344 no 498 0.0963155519374314 93 760979 SGTC_455 paf C-16 10 µM 1.30156802913585 0.143064134715787 no 499 0.0965320474395427 121 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2308 7584454 197.62 µM 1.30013340160157 0.14333593936405 no 500 0.0967776257232129 133 893577 SGTC_3159 9100096 49.47 µM 1.29881503184894 0.143586025079961 no 501 0.0970037073496774 104 25236875 SGTC_1154 4088-0362 150 µM 1.29851310608255 0.143643339752367 no 502 0.0970555378335496 130 6618304 SGTC_655 k060-0012 42 µM 1.29834981897951 0.143674343031732 no 503 0.097083577196871 144 5994525 SGTC_1991 st073000 8.92 µM 1.2982682150865 0.143689838833667 no 504 0.0970975922963756 134 4301969 YIL048W NEO1 SGTC_355 1311-2252 105 µM 1.29628263114392 0.144067229901929 no 505 0.0974390651365063 128 5338538 SGTC_653 0203-0016 55.2 µM 1.29422857405284 0.144458338132814 no 506 0.0977932398148495 135 295302 SGTC_799 1310-0557 151 µM 1.29313526888563 0.144666803316448 no 507 0.0979821394218515 133 5354492 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.29271641557543 0.144746721532417 no 508 0.0980545790586081 127 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.29033434006831 0.145201792578008 no 509 0.0984672993786639 109 364106 SGTC_2705 st078069 42.8 µM 1.29015389902679 0.145236303166493 no 510 0.0984986144848952 118 1530061 SGTC_2207 7258803 200 µM 1.28850943327931 0.145551072869709 no 511 0.0987843436267521 125 3666799 SGTC_1826 st055655 41.6 µM 1.28848150000332 0.145556423580151 no 512 0.0987892023215853 120 676168 SGTC_899 1083-0020 478 µM 1.28797069963097 0.145654292388173 no 513 0.0988780814274238 135 767123 SGTC_274 sirtinol 40.1 µM 1.28772865707288 0.145700682930275 no 514 0.0989202171813418 129 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_90 0870-0863 4.608 µM 1.28519664509557 0.146186570731622 no 515 0.0993617878530579 138 1738164 SGTC_1911 st060208 74.3 µM 1.28123932870943 0.14694814883331 no 516 0.100054808007766 144 688783 SGTC_2120 5538279 151.968 µM 1.2773850355903 0.147692453831721 no 517 0.100733172629171 110 2058197 SGTC_2544 sphondin 68.51 µM 1.27632346246596 0.147897897592214 no 518 0.100920599786611 156 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2656 pseudo-anisatin 100 µM 1.27628375018766 0.147905586726972 no 519 0.100927616159739 122 6708809 A neurotoxin. SGTC_1147 3809-1045 12.3 µM 1.27152742908143 0.148828446479259 no 520 0.101770537883903 137 325925 SGTC_2033 5192550 145 µM 1.27096885500555 0.148937077468102 no 521 0.101869864423166 124 182073 SGTC_2210 7115885 190.385 µM 1.26874131388528 0.14937081446248 no 522 0.102266671117131 121 2927039 SGTC_3221 9128209 49.47 µM 1.26540015648541 0.150022969391219 no 523 0.102863959575946 122 16460723 SGTC_2477 5967686 25.23 µM 1.26519514740281 0.150063046494506 no 524 0.102900690781354 129 776118 SGTC_2280 7785178 200 µM 1.26350059899166 0.150394586070321 no 525 0.103204665740383 120 2954328 SGTC_190 3970-0790 3.722 µM 1.2632970343315 0.150434446447521 no 526 0.103241225818293 123 2832352 SGTC_447 ml7 120 µM 1.26156334804525 0.150774208015274 no 527 0.103552975875854 106 4216 Selective myosin light chain kinase inhibitor. SGTC_719 2810-4230 27.3 µM 1.26131762803317 0.150822404639437 no 528 0.103597216264464 114 721079 SGTC_207 4185-0010 4.486 µM 1.26092949634519 0.150898555421359 no 529 0.103667124945587 135 3761753 SGTC_2990 9074105 71.4286 µM 1.26017403089804 0.151046849840976 no 530 0.103803294407291 129 6502001 SGTC_2979 9012552 45.46 µM 1.25968432625641 0.151143028415611 no 531 0.103891630885789 139 17100905 SGTC_317 4495-0002 170 µM 1.25916527143824 0.151245015871498 no 532 0.103985321270079 125 15991618 SGTC_2391 6285546 200 µM 1.25788090356334 0.151497574030559 no 533 0.104217415459041 117 846083 SGTC_2073 5212005 126 µM 1.25445996611267 0.15217163464962 no 534 0.104837434115605 138 691789 SGTC_2007 4011539 71.82 µM 1.25085071222143 0.15288495673608 no 535 0.105494474462886 103 45595301 SGTC_1445 4239-0156 97.7 µM 1.25043303309711 0.15296764849038 no 536 0.105570701972541 125 4008346 SGTC_628 1636-0253 16 µM 1.24968908370172 0.153115008383542 no 537 0.105706573280192 140 4456143 SGTC_1319 1306-0155 43.7 µM 1.24941392675017 0.153169534706945 no 538 0.105756858623757 141 3122360 SGTC_2154 5570129 200 µM 1.24887096171806 0.153277168815145 no 539 0.105856137018419 133 673366 SGTC_1218 1348-1416 30.7 µM 1.24684741227763 0.153678746356717 no 540 0.106226726037651 134 6787668 SGTC_3178 9107506 49.47 µM 1.24679876678701 0.153688408720385 no 541 0.106235646400934 150 8897194 SGTC_1689 st020265 53.493 µM 1.2464007115169 0.153767488811897 no 542 0.106308660085319 129 5758320 YPR016C TIF6 SGTC_3325 9138760 55.175 µM 1.24459786249813 0.154125991018379 no 543 0.106639803243948 119 43844959 SGTC_482 fipronil 114 µM 1.24431070452405 0.154183144291614 no 544 0.10669261642145 100 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_545 4218-0007 221 µM 1.24313771888917 0.154416750091165 no 545 0.106908544232312 145 2840508 SGTC_3323 9138564 53.9225 µM 1.24216754404154 0.154610141852236 no 546 0.107087375910377 137 43912313 YNL103W MET4 SGTC_2412 st077135 33.4 µM 1.24056211099578 0.154930515536437 no 547 0.107383778021814 129 13258915 SGTC_638 3970-0837 4.09 µM 1.23893829502632 0.155255003343485 no 548 0.107684175173426 108 4118451 YLR208W SEC13 SGTC_2797 7859098 81.82 µM 1.23867890462774 0.15530687895379 no 549 0.107732217016028 142 972681 SGTC_117 lucigenin 22.078 µM 1.23456168536516 0.156131815331399 no 550 0.10849683798206 138 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2444 5485484 36.41 µM 1.23187706329008 0.156671265214431 no 551 0.108997505304507 155 6790631 SGTC_3282 9108498 15.4605 µM 1.23183156521264 0.156680418190357 no 552 0.109006004733738 138 16459645 SGTC_94 0334-0113 514.748 µM 1.22859221615109 0.15733299173789 no 553 0.10961236767815 134 6795178 SGTC_2945 9067681 61.76 µM 1.22814058595025 0.157424115288472 no 554 0.109697098816805 167 16456930 SGTC_1017 4239-0030 168 µM 1.22775518565707 0.15750190333087 no 555 0.109769441620394 141 1149593 SGTC_1431 4049-0260 9.09 µM 1.22355909189336 0.158350464735246 no 556 0.110559299823474 153 3854841 SGTC_2957 9076800 11.52 µM 1.21869370377662 0.159338123420327 no 557 0.111480234291135 122 16459615 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.2164919387958 0.159786397763633 no 558 0.111898790004232 138 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1557 sumaresinolic acid 42.3 µM 1.21556178421738 0.159976022787124 no 559 0.112075949707797 101 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_488 nitrendipine 139 µM 1.21471527011719 0.160148724389851 no 560 0.112237353220476 125 4507 Dihydropyridine L-type calcium channel blocker. SGTC_908 3448-7491 47.7 µM 1.21436864120432 0.160219477059404 no 561 0.112303492325801 133 1203031 SGTC_463 ikarugamyin 104 µM 1.21425823238332 0.160242017607938 no 562 0.112324564911436 89 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_34 0469-0683 81.75 µM 1.21352733089939 0.160391287312943 no 563 0.112464135755685 121 3690923 SGTC_174 3553-0389 74.3 µM 1.2104872712534 0.161013123686347 no 564 0.113045986064356 133 738071 SGTC_1443 4112-3303 14 µM 1.21032913725707 0.161045512581881 no 565 0.113076310692987 154 704433 SGTC_60 0986-0278 202 µM 1.20735783450143 0.16165488320143 no 566 0.113647183325112 133 3110598 SGTC_1828 st055811 49 µM 1.2072355660281 0.161679990825535 no 567 0.113670718545378 122 5877589 SGTC_98 0074-0023 107.663 µM 1.20657349227733 0.161815990692018 no 568 0.113798220176753 118 3563821 SGTC_3177 9107506 49.47 µM 1.20328459989622 0.162492682993142 no 569 0.114433103216274 125 8897194 SGTC_2880 9042983 58.44 µM 1.20289481435122 0.162573003567521 no 570 0.1145085136581 166 6464714 SGTC_3272 9137413 49.47 µM 1.20205767831908 0.162745594048617 no 571 0.114670590977087 150 17614870 SGTC_2841 9004761 38.96 µM 1.20154517068152 0.162851315403387 no 572 0.1147698977478 119 2991039 SGTC_453 enantio-paf c16 10 µM 1.20071171546706 0.163023337969713 no 573 0.114931524015427 170 13871343 A lipid and platelet activating factor SGTC_2825 7998094 58.44 µM 1.19974321120792 0.163223382564683 no 574 0.115119542707282 135 2987815 SGTC_2896 9052656 71.43 µM 1.1984982986749 0.163480753484276 no 575 0.115361542472123 186 6469436 SGTC_613 3914-0030 117 µM 1.19764922147702 0.163656441236621 no 576 0.115526802675641 102 1145395 SGTC_1913 st060213 96.1 µM 1.19430953619735 0.164348664718658 no 577 0.116178454353907 151 688959 SGTC_221 trifluoperazine 10.304 µM 1.19383906317319 0.164446332959766 no 578 0.116270463996018 168 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_457 grayanotoxin iii 135 µM 1.19160694823016 0.164910223296142 no 579 0.116707699644139 161 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_266 formosanin C 406 nM 1.19065102034878 0.165109148386484 no 580 0.116895306733655 164 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.19047969248193 0.165144817496186 no 581 0.116928953521848 131 5379071 SGTC_169 k015-0017 16.025 µM 1.19035969849524 0.16516980226704 no 582 0.116952523023466 151 1840002 SGTC_920 mycophenolic acid 780.421 nM 1.18983936149489 0.165278173508761 no 583 0.117054767799664 125 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2302 7771753 200 µM 1.18965526528395 0.165316526475579 no 584 0.117090957358202 133 2203047 SGTC_996 3970-0799 1.8 µM 1.18886038327749 0.16548219122992 no 585 0.117247305949744 171 6615648 YGL040C HEM2 SGTC_2537 larixol 68.93 µM 1.18632481070985 0.166011358100315 no 586 0.117747026100866 152 6708759 SGTC_2970 9090938 41.86 µM 1.18391680314388 0.166514913664642 no 587 0.118222998967367 153 17217104 SGTC_2787 5284540 71.43 µM 1.18159086759577 0.167002241718037 no 588 0.118684039453956 143 736958 SGTC_359 0081-0058 15.9 µM 1.18102980774045 0.167119932059762 no 589 0.118795441089472 156 3494159 SGTC_22 0964-0034 14.468 µM 1.1783292768378 0.167687155012536 no 590 0.11933268023837 178 138402 SGTC_3029 9088683 49.47 µM 1.1769518804703 0.167976942002978 no 591 0.119607356489912 124 25236615 SGTC_701 4424-0219 185 µM 1.17661986828036 0.168046841403145 no 592 0.119673632013769 150 2911779 SGTC_1341 1486-1360 280 µM 1.17575959025188 0.168228045074389 no 593 0.119845479257598 157 3976547 SGTC_349 k015-0014 24 µM 1.17533363003076 0.16831781322422 no 594 0.11993063250277 150 2196908 SGTC_3254 9136651 49.47 µM 1.17465887862474 0.168460075428293 no 595 0.120065608600759 153 16454030 SGTC_310 1273-0058 1.06 µM 1.17288807156233 0.16883379371817 no 596 0.120420346824606 124 2734232 SGTC_1768 st044301 37.178 µM 1.17111595158439 0.169208321955381 no 597 0.120776086421794 184 3931349 SGTC_2184 6075246 200 µM 1.17010897420109 0.169421378815128 no 598 0.120978558733784 143 2267320 SGTC_1646 st011709 75.6 µM 1.16863390576764 0.169733785314998 no 599 0.121275580784545 154 5757843 SGTC_2728 chlorpromazine 9.18 µM 1.16562755808129 0.170371646313668 no 600 0.121882530385715 153 2726 A thorazine and dopamine antagonist. SGTC_3171 9103192 49.47 µM 1.16257744613547 0.17102035978857 no 601 0.122500492937143 140 13018434 SGTC_1853 st056710 91.2 µM 1.1612899932716 0.171294655474846 no 602 0.122761993785518 155 269167 SGTC_1777 st045864 34.765 µM 1.15960553033428 0.171653959824157 no 603 0.123104724162209 173 4691462 SGTC_2982 9019404 25.97 µM 1.1575555606944 0.17209187760715 no 604 0.123522726635186 127 22333232 SGTC_21 0849-0113 22.993 µM 1.15729428198598 0.172147743572099 no 605 0.123576074445301 144 1560156 SGTC_2330 7979373 200 µM 1.15550875634731 0.172529829993912 no 606 0.12394107446266 145 1863007 SGTC_499 genistein 192 µM 1.15405037001345 0.172842312486628 no 607 0.124239759439635 133 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2961 9083290 32.55 µM 1.15212439860276 0.173255534845524 no 608 0.124634979216851 145 17741490 SGTC_1637 st007924 17.4 µM 1.15192965879916 0.173297351785782 no 609 0.124674989746348 133 683336 SGTC_976 1348-1067 47.6 µM 1.15118845244947 0.173456571555162 no 610 0.124827357404839 143 5310671 YGL099W LSG1 SGTC_1670 st016595 4.04 µM 1.14804747867881 0.174132322235831 no 611 0.125474482106697 163 597879 SGTC_1564 D-Arginine 115 µM 1.1451516762537 0.174756807030141 no 612 0.126073166044448 173 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.14479117953856 0.174834648156534 no 613 0.126147835008247 169 616764 SGTC_35 0133-0054 64.071 µM 1.14407715403161 0.174988890792205 no 614 0.126295820668375 164 99677 SGTC_1470 k295-0292 231 µM 1.14287384957736 0.175249021963167 no 615 0.126545485697737 163 5045612 SGTC_2029 5175081 200 µM 1.14152449144176 0.17554101863878 no 616 0.126825863032644 135 1380876 SGTC_1340 1486-1359 257 µM 1.14065136761549 0.175730123983869 no 617 0.127007515988474 161 4309068 SGTC_368 fentichlor 4.58 µM 1.13675810716568 0.17657491496202 no 618 0.127819710341165 159 7329 A pesticide. SGTC_3091 9116372 49.47 µM 1.13421893784281 0.177127265766253 no 619 0.128351361054819 143 17169793 SGTC_1685 st024049 53.0905 µM 1.13146232842482 0.177728150994131 no 620 0.1289302752885 153 1941139 SGTC_445 e6 berbamine 66 µM 1.12817748135497 0.178445858567393 no 621 0.129622486036314 173 6610268 A calcium/calmodulin antagonist. SGTC_528 3492-0019 172 µM 1.12730958901581 0.178635789222031 no 622 0.129805804780367 175 2869262 SGTC_2735 sertaconazole 140 nM 1.12725225771022 0.178648340158009 no 623 0.129817920783438 165 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_535 2293-4129 48.2 µM 1.12605901339779 0.178909690546148 no 624 0.130070270581267 184 396118 YIL048W NEO1 SGTC_1137 ixabepilone 100 µM 1.12500152726038 0.179141507504134 no 625 0.130294193546281 153 154225 A novel microtubule stabilizer. SGTC_2674 ligustilide 100 µM 1.12466339536908 0.17921567097884 no 626 0.130365849300801 150 5319022 A signalling regulator. SGTC_1271 0832-2808 169 µM 1.12240256822646 0.179712041015928 no 627 0.130845656502307 180 3663794 SGTC_2261 9010538 184.68 µM 1.11977361853312 0.180290318300454 no 628 0.131405122063744 156 6457250 SGTC_599 1935-0052 86.5 µM 1.11854307474695 0.180561395788558 no 629 0.131667560160815 134 9557311 SGTC_17 0960-0276 49.807 µM 1.1167692313859 0.18095260675066 no 630 0.13204650389034 172 6821114 SGTC_2064 5220758 200 µM 1.11203872346147 0.181998487660048 no 631 0.133060750580975 172 788518 SGTC_443 clozapine 122 µM 1.110399623219 0.182361760809049 no 632 0.133413430254706 149 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2715 st079500 56.4 µM 1.10849295071219 0.182784905478784 no 633 0.133824490928601 169 28246688 SGTC_42 0133-0086 60.653 µM 1.10605697012825 0.183326409566749 no 634 0.134350930874413 196 162923 Model of phenazepam hydroxylation. SGTC_2305 7443522 69.23 µM 1.10501247017781 0.183558901817786 no 635 0.134577092861989 162 5415886 SGTC_2895 9054447 58.44 µM 1.10456334702883 0.18365892732063 no 636 0.134674420250149 161 2697450 SGTC_944 3370-0224 231 µM 1.10405069508537 0.183773143002657 no 637 0.134785573692798 121 4580514 SGTC_53 0973-0023 39.979 µM 1.10320048918377 0.18396266113437 no 638 0.134970054476907 152 674768 SGTC_1288 0973-0013 65.5 µM 1.10108054502474 0.184435744533049 no 639 0.135430801748337 150 4315430 SGTC_1773 st048542 73.5835 µM 1.10071326398051 0.184517783241367 no 640 0.135510735789883 196 3237138 SGTC_2732 terfenadine 20 µM 1.09777629319372 0.185174623665389 no 641 0.136151092886735 182 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1199 1638-0010 4.46 µM 1.09675585737766 0.185403179106995 no 642 0.136374065764865 168 3111136 SGTC_1282 0886-0010 32.4 µM 1.09635069335915 0.185493975589204 no 643 0.136462666388328 180 2836211 YNL267W PIK1 SGTC_793 0488-0545 106 µM 1.09613146476946 0.185543115801551 no 644 0.136510623360197 166 292548 SGTC_1277 0873-0036 22 µM 1.09565409373643 0.185650146734421 no 645 0.136615089710454 164 5965735 SGTC_806 3966-4455 5.86 µM 1.09497966395502 0.185801425309487 no 646 0.136762772919998 145 714982 SGTC_1809 st050081 57.6 µM 1.09368288091846 0.186092516158506 no 647 0.137047042468663 170 5036894 SGTC_1471 k673-0312 37 µM 1.08965487185921 0.186998490803923 no 648 0.137932601067911 172 24099884 SGTC_2496 diffractaic acid 79.83 µM 1.08787119385646 0.187400543592839 no 649 0.138325987267555 159 94870 An apoptosis inducer which activates caspases. SGTC_1087 pterostilbene 9.05 µM 1.08754039418275 0.187475166716435 no 650 0.138399028382223 180 5281727 Similar to reservatol, lowers cholesterol. SGTC_1111 tnp00062 510.699 nM 1.08698261610591 0.18760103412553 no 651 0.138522246222788 158 676306 SGTC_543 3844-1095 191 µM 1.0864232636561 0.187727309225917 no 652 0.13864588690122 197 4230703 SGTC_711 k292-0785 179 µM 1.08509395428856 0.18802761445066 no 653 0.13894002236292 169 4146315 SGTC_2287 7945887 168.79 µM 1.08378298153525 0.188324067499393 no 654 0.139230516322958 162 1245853 SGTC_1676 st018489 23.4 µM 1.08134860694632 0.188875322104182 no 655 0.139771036690971 148 3696235 SGTC_2065 5221596 34.26 µM 1.0795438639817 0.189284640176545 no 656 0.140172675385399 160 788581 SGTC_3184 9108758 49.47 µM 1.0786984069973 0.189476578619436 no 657 0.140361098030205 170 902885 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.07809284482337 0.189614128935405 no 658 0.140496162220078 181 5282309 SGTC_299 1273-0059 1.44 µM 1.0776069481041 0.189724542270095 no 659 0.140604600087479 171 2848077 SGTC_1753 st043925 64 µM 1.07727772717108 0.189799375659441 no 660 0.140678104800461 153 670181 SGTC_1394 3474-0001 65.7 µM 1.07694937871429 0.189874028807135 no 661 0.140751440687276 126 5017666 YIL048W NEO1 SGTC_704 1310-0270 142 µM 1.07572781406774 0.190151921646018 no 662 0.141024502148576 172 5718033 SGTC_192 3455-0609 60.9 µM 1.07341021508107 0.190679836938593 no 663 0.141543551634434 148 3769639 SGTC_2122 5258151 111.688 µM 1.07070817919189 0.191296455866768 no 664 0.142150331977189 155 2173356 SGTC_693 4161-2696 114 µM 1.06924194730815 0.191631568727963 no 665 0.142480330839255 184 805759 SGTC_312 4092-0653 6.84 µM 1.06901309305413 0.191683906658066 no 666 0.142531884849229 193 1148278 SGTC_1647 st011722 22.4 µM 1.06741035938847 0.192050689861813 no 667 0.142893286276434 167 2854783 SGTC_3312 9133330 71.43 µM 1.06720535591863 0.192097635559767 no 668 0.142939557272992 174 17617324 SGTC_2696 st077691 74.316 µM 1.06435830383029 0.192750334815193 no 669 0.143583207492554 173 757133 SGTC_942 3253-1115 227 µM 1.06400101413407 0.192832340640643 no 670 0.143664120065136 180 46497897 SGTC_1468 k284-1086 134 µM 1.06168055213462 0.193365456135599 no 671 0.144190365554279 176 15996457 SGTC_1588 farnesol 29.9 µM 1.06084134946881 0.193558480318786 no 672 0.144381003546575 166 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_105 0111-0055 734.78 µM 1.05874878501215 0.194040300635545 no 673 0.144857101826115 150 5179370 SGTC_2183 6420625 130.508 µM 1.05753453833852 0.19432021993478 no 674 0.145133850208862 194 2897619 SGTC_737 1950-0117 57.9 µM 1.05430682722633 0.195065496151658 no 675 0.1458712320084 174 5393513 SGTC_2556 citropten 84.59 µM 1.05240104446619 0.195506354761608 no 676 0.146307794847924 149 2775 A potential DNA crosslinker. SGTC_32 0928-0142 34.1 µM 1.05051158068416 0.195944035167525 no 677 0.146741484698429 170 2244242 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.04973681909014 0.196123674722157 no 678 0.146919565326278 185 688788 SGTC_3269 9137823 49.47 µM 1.04706930838218 0.196742938774162 no 679 0.147533806720795 134 17682936 SGTC_2849 9019321 12.99 µM 1.04607421304243 0.19697425364442 no 680 0.147763384940259 162 16489627 SGTC_3213 9129884 49.47 µM 1.04512226939468 0.197195691689573 no 681 0.147983231416788 159 17190742 SGTC_360 0957-0399 1.01 µM 1.043119112206 0.197662151286232 no 682 0.148446565002709 169 6752301 YPR165W RHO1 SGTC_2971 9092186 9.93 µM 1.04181750898689 0.197965602615573 no 683 0.148748147443037 156 25236400 SGTC_2213 7173844 200 µM 1.04118097425972 0.198114104539802 no 684 0.148895782014561 172 892728 SGTC_3291 9121177 71.43 µM 1.04001194745969 0.198387010637197 no 685 0.149167174989123 158 17015612 SGTC_82 0054-0107 293.755 µM 1.03887177082864 0.198653400140421 no 686 0.149432188352032 171 3104697 SGTC_87 0100-0052 35.5 µM 1.03703002621561 0.199084158525851 no 687 0.14986093192341 192 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_723 4182-0001 115 µM 1.03630090567717 0.199254845026129 no 688 0.150030891885177 166 744821 YLR208W SEC13 SGTC_1045 1348-1485 165 µM 1.03625328398643 0.199265996288859 no 689 0.150041997098907 176 6810614 SGTC_3012 9080433 71.4286 µM 1.03523894503246 0.199503606718201 no 690 0.150278667595845 193 17688859 SGTC_2368 9071271 200 µM 1.03473057625175 0.199622756999085 no 691 0.150397376210105 167 27209959 SGTC_1747 st037496 66.6 µM 1.03387096024744 0.199824329174072 no 692 0.15059824626627 202 723305 SGTC_1802 st050112 57.9 µM 1.03365568770279 0.199874827799732 no 693 0.150648577862563 161 4662563 SGTC_880 0833-0487 87.2 µM 1.03340400279192 0.199933877768045 no 694 0.150707437021174 189 76075 SGTC_835 0312-0010 67.2 µM 1.03303299749466 0.200020941648555 no 695 0.150794228424217 187 1626196 SGTC_351 caspofungin 25 nM 1.03231236090721 0.200190118690251 no 696 0.150962906160342 192 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1690 st023502 41.2 µM 1.03064224951949 0.200582525403316 no 697 0.151354307845755 179 24207482 SGTC_1862 st057513 3.81 µM 1.02927665598204 0.200903726045272 no 698 0.151674844832654 171 5393163 SGTC_2806 7952793 58.44 µM 1.02869388945787 0.201040892198203 no 699 0.151811771123073 169 2972490 SGTC_2323 6148992 148.28 µM 1.02673792041271 0.201501680465202 no 700 0.152271944125042 161 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2707 st078556 66.6 µM 1.02635540458715 0.201591867679992 no 701 0.152362045233618 156 17250899 SGTC_1469 k284-2957 126 µM 1.02634679937359 0.201593896842094 no 702 0.152364072587472 169 23884841 SGTC_3028 9087778 49.47 µM 1.02414164929565 0.20211428798519 no 703 0.152884187340177 180 17217395 SGTC_2661 dactinomycin 12.96 µM 1.02127067531742 0.202793009420975 no 704 0.153563107918268 169 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1495 4469-0029 237 µM 1.02034906601009 0.203011173697497 no 705 0.153781470404167 168 793680 SGTC_1272 0839-0021 27 µM 1.01628968729543 0.203973780836417 no 706 0.154745729018428 191 5027250 SGTC_1139 k015-0024 46.9 µM 1.01429956454942 0.204446693719735 no 707 0.15521991588648 181 2766652 SGTC_1781 st038725 66.3 µM 1.01203205141242 0.204986317507354 no 708 0.155761364394648 197 4270275 YIL048W NEO1 SGTC_3236 9132701 49.47 µM 1.01079682640337 0.20528063281484 no 709 0.156056841191074 178 24282524 SGTC_581 0958-0271 211 µM 1.01011790508583 0.2054425052841 no 710 0.156219402410238 164 4591145 SGTC_1347 1493-0251 600 nM 1.00980895469586 0.205516192166754 no 711 0.156293414548903 180 3986378 SGTC_1756 st041558 35.5 µM 1.00914487057929 0.205674634096128 no 712 0.156452580674461 185 3955792 SGTC_1943 st076331 65.2 µM 1.0057839834281 0.206477609792179 no 713 0.157259746748692 179 24208415 SGTC_3097 9117246 49.47 µM 1.00332658289522 0.207065900152239 no 714 0.157851657098282 174 16423892 SGTC_2322 7413319 38.22 µM 1.002113765074 0.207356608256191 no 715 0.158144325227572 193 1840400 SGTC_886 0866-0150 153 µM 1.00112979544694 0.207592639468433 no 716 0.158382030938853 182 271463 SGTC_1260 0700-1617 7.75 µM 1.00105285927542 0.207611101339257 no 717 0.158400626923547 185 2853078 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.00046194205364 0.207752932225481 no 718 0.158543503295172 199 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2266 7929956 200 µM 0.989694665140146 0.210347282481121 no 719 0.16116169168261 191 2967153 SGTC_2260 7964312 200 µM 0.989218681677909 0.210462406906368 no 720 0.161278080018454 185 231951 SGTC_1594 piperine 70.1 µM 0.9886995309114 0.210588014211241 no 721 0.161405086198214 177 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3021 9087658 49.47 µM 0.984918985657985 0.211504033901234 no 722 0.162331933399169 166 25237042 SGTC_1864 st057645 30.4 µM 0.984396049326152 0.211630923908682 no 723 0.162460409894677 204 688666 SGTC_2195 6536160 144.242 µM 0.984113179530658 0.211699580565153 no 724 0.162529933726579 163 3834386 SGTC_2015 5119600 184 µM 0.983651377124306 0.211811694804367 no 725 0.162643477269954 209 2828786 SGTC_1189 1431-2119 7.28 µM 0.982773954083941 0.21202480717165 no 726 0.16285935175284 197 3107275 SGTC_1832 st054113 55 µM 0.982666198432296 0.212050987981091 no 727 0.162885875972678 164 1251267 SGTC_1244 0416-0015 52.5 µM 0.981069226635282 0.212439217174476 no 728 0.163279302308795 177 96201 SGTC_1563 conessine 56.1 µM 0.980587050931794 0.212556517272908 no 729 0.163398211264859 155 441082 An anti-amoebic, histamine inhibitor. SGTC_1972 st070201 17.4 µM 0.978404456473027 0.21308795549876 no 730 0.163937162481596 176 2829099 SGTC_2438 5259590 200 µM 0.976252477584466 0.213612697249024 no 731 0.164469681761328 184 1201127 SGTC_600 1495-0418 41.6 µM 0.975862199717554 0.213707943774204 no 732 0.164566378189737 211 5377768 SGTC_602 3130-1533 38.1 µM 0.975426119165192 0.213814397609679 no 733 0.164674466402967 210 720941 SGTC_625 k213-0058 121 µM 0.973163799977092 0.214367159255121 no 734 0.165235949616159 206 3655420 SGTC_2607 solasodine 47.35 µM 0.97290898691429 0.214429470800495 no 735 0.165299269015218 208 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3309 9129340 25.759 µM 0.971236648345239 0.2148386828905 no 736 0.165715223958754 186 17158987 SGTC_3172 9105863 49.47 µM 0.969148858085768 0.215350189906532 no 737 0.166235461730511 187 2348785 SGTC_755 1995-0008 37.3 µM 0.968961025830936 0.215396243285207 no 738 0.166282317634956 156 689533 SGTC_657 3534-0529 86.7 µM 0.968526065318633 0.215502910379543 no 739 0.166390853935952 191 1049549 SGTC_2582 agaric acid 100 µM 0.963483446640154 0.216741766442197 no 740 0.16765248367378 213 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3216 9129716 49.47 µM 0.962918415695443 0.216880837750543 no 741 0.167794233532792 171 8056934 SGTC_2649 anisomycin 9.56 µM 0.962886228684779 0.216888761505948 no 742 0.16780231064171 188 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1626 st003712 1.76 µM 0.962732847332345 0.216926523021757 no 743 0.167840804075788 216 24207035 SGTC_3113 9123498 49.47 µM 0.962130076264127 0.217074958242175 no 744 0.167992133908356 233 8897275 SGTC_2381 9035592 200 µM 0.959997047005973 0.217600697834183 no 745 0.168528350572127 178 4749657 SGTC_130 0136-0219 337.655 µM 0.95914451969086 0.217811030348271 no 746 0.168742972642706 221 234244 SGTC_735 3076-0345 636 µM 0.958103681289753 0.218067981218407 no 747 0.169005239677738 204 2888990 SGTC_1078 idebenone 36.1 µM 0.956602009566172 0.218439005341087 no 748 0.169384087072833 217 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1358 1509-0022 2.48 µM 0.95577624322889 0.218643185611378 no 749 0.169592646597498 211 3258434 SGTC_2931 9014674 55.67 µM 0.953086107053576 0.219309114295761 no 750 0.170273222326333 192 2996810 SGTC_1920 st075728 45.7 µM 0.952233529143128 0.219520408358186 no 751 0.170489280068115 177 3400306 SGTC_516 3992-2719 87.3 µM 0.950804832211616 0.219874743809829 no 752 0.170851729568124 155 5350887 YDR037W KRS1 SGTC_1845 st056753 3.01 µM 0.94851461656149 0.220443431409729 no 753 0.171433767669436 191 5375839 SGTC_2850 9015429 58.44 µM 0.947779845593531 0.220626062178537 no 754 0.171620771428959 217 6457570 SGTC_1559 coumarin 343 70.1 µM 0.947249241153217 0.220758000279154 no 755 0.171755894550037 187 108770 A hepatotoxic, DNA x-linker. SGTC_864 0469-0573 172 µM 0.947189970198771 0.220772741176442 no 756 0.171770992641688 204 689425 SGTC_358 0075-0058 9.45 µM 0.947098349531676 0.220795528671461 no 757 0.171794332844272 194 1069125 SGTC_227 fluconazole 33.516 µM 0.946301615689258 0.2209937456309 no 758 0.171997384764141 237 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1562 morin hydrate 59.1 µM 0.945263048785271 0.221252280341299 no 759 0.172262299074613 190 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_486 niguldipine 82 µM 0.945066007739783 0.221301350092787 no 760 0.172312589038578 204 1236 A calcium channel blocker. SGTC_850 0388-0143 75.9 µM 0.944435353020785 0.22145844585555 no 761 0.172473611369579 190 67273 SGTC_176 1486-1328 72.834 µM 0.943471087667212 0.221698767075161 no 762 0.172719998534836 188 22310231 SGTC_2172 5754775 163.918 µM 0.942084860473559 0.222044513636099 no 763 0.173074597469889 224 2263357 SGTC_710 3448-4187 58 µM 0.939922742451323 0.222584393397549 no 764 0.173628595401615 203 3946412 SGTC_691 1548-0686 185 µM 0.93940936537057 0.22271269324948 no 765 0.173760303216356 234 46495133 SGTC_307 1501-1223 22.3 µM 0.938114978450181 0.22303636502687 no 766 0.174092662542826 179 2830329 SGTC_1561 5-methoxyflavone 52.9 µM 0.937166591263713 0.223273686757963 no 767 0.174336435962255 183 94525 SGTC_1259 0671-0132 43 µM 0.93586814519618 0.223598839206094 no 768 0.174670540043011 194 X1259 SGTC_1302 1159-0335 255 µM 0.935628138424133 0.223658970360292 no 769 0.174732340843289 182 649284 SGTC_900 1112-0045 141 µM 0.935324037066651 0.223735172938317 no 770 0.174810665681368 192 56211 YIL048W NEO1 SGTC_1784 st039334 36.3 µM 0.932524992150039 0.224437258318928 no 771 0.175532638479418 222 3496984 SGTC_2642 cholecalciferol 100 µM 0.931571058759765 0.22467681912298 no 772 0.17577912284071 181 9821465 A vitamin D precursor, similar to steriods. SGTC_945 3381-0768 11.3 µM 0.931282853978084 0.224749224359647 no 773 0.175853634428477 207 1126236 YIL048W NEO1 SGTC_2351 9026858 72.31 µM 0.931276990180547 0.224750697649668 no 774 0.175855150644477 209 1409300 SGTC_3154 9100113 49.47 µM 0.929262026646478 0.225257285162606 no 775 0.176376654747355 201 25237525 SGTC_2332 7982454 138.89 µM 0.927323942714194 0.22574515373536 no 776 0.176879183376974 219 2981748 SGTC_1408 3909-7976 48.8 µM 0.927295631346868 0.225752284905153 no 777 0.176886530972662 217 24152374 SGTC_1877 wortmannin 25 µM 0.925721223679446 0.226149052939821 no 778 0.177295437632888 203 312145 A covalent inhibitor of PI 3-kinase. SGTC_85 0868-0259 160.055 µM 0.92553711057873 0.226195477186514 no 779 0.177343294615562 188 83173 SGTC_715 0868-0130 184 µM 0.919035241803018 0.22783837691834 no 780 0.179038569578667 187 2876258 SGTC_2258 7960471 200 µM 0.918625466057892 0.227942143973387 no 781 0.179145753570011 189 2974708 SGTC_787 4152-0075 138 µM 0.917856520273668 0.228136934993118 no 782 0.179346993658939 192 9566539 SGTC_1711 st032263 62.8 µM 0.917721663308629 0.228171106897605 no 783 0.179382301595016 220 3958979 SGTC_2375 9072683 200 µM 0.917580394574819 0.228206906589986 no 784 0.179419292932056 214 16798029 SGTC_382 3229-0966 23.2 µM 0.917116547881408 0.228324474753398 no 785 0.179540785300791 193 5722370 SGTC_3193 9111931 49.47 µM 0.916171747557685 0.228564052316161 no 786 0.179788410626809 220 17087244 SGTC_2947 9072639 7.68 µM 0.91481939744219 0.228907219807778 no 787 0.180143224931439 210 16488146 SGTC_476 mead acid 10 µM 0.913856800880829 0.229151660893562 no 788 0.18039604771051 198 5312531 An omega 9 fatty acid. SGTC_1255 0566-0045 221 µM 0.913848176663477 0.229153851582666 no 789 0.18039831383817 208 2788469 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.913748416611931 0.229179193084616 no 790 0.18042452841494 208 16623 A steroid. SGTC_2426 5582046 32.21 µM 0.913088046432121 0.22934698295068 no 791 0.180598118309112 190 2251934 SGTC_827 3253-0474 693 µM 0.912666316134776 0.229454174129036 no 792 0.180709032305692 219 5402065 SGTC_1159 4092-0538 61.2 µM 0.911057970652174 0.229863224861823 no 793 0.1811324149825 217 717301 SGTC_750 4073-0104 132 µM 0.910379179874863 0.230035984246013 no 794 0.181311286943528 181 22330957 SGTC_1694 st024011 44.9 µM 0.910119277636999 0.230102151327219 no 795 0.181379804512188 216 2787533 SGTC_906 1165-0455 526 µM 0.909467998162064 0.230268003751986 no 796 0.181551571370609 204 3252859 SGTC_405 ebelactone b 50 µM 0.909178575024119 0.230341728629996 no 797 0.181627935785108 178 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2918 7977171 22.06 µM 0.904782760870206 0.231463097408782 no 798 0.182790243127103 208 2236483 SGTC_2425 5628681 7.85 µM 0.902307219209511 0.232095943474371 no 799 0.183446845848187 207 5714958 SGTC_1204 4049-0315 18.3 µM 0.901770276615811 0.232233334175139 no 800 0.183589456143158 193 588402 SGTC_1235 benzylparaben 21.5 µM 0.89997237707919 0.232693702753173 no 801 0.18406747548991 213 7180 SGTC_1825 st052143 62.6 µM 0.897103842624118 0.233429266288702 no 802 0.184831754232404 205 674173 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.896750330005621 0.233520004902967 no 803 0.184926078787326 211 97141 SGTC_2123 5259487 200 µM 0.896534967513275 0.233575293122976 no 804 0.184983556660877 191 2173474 SGTC_2868 9035608 32.47 µM 0.895345955449894 0.233880668924932 no 805 0.185301090642829 197 6462614 SGTC_1749 st037932 54.2 µM 0.894050703886369 0.234213581986702 no 806 0.185647381522689 214 594497 SGTC_217 ketoconazole 989 nM 0.893641859828682 0.234318719904384 no 807 0.185756770998248 205 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2783 7738165 71.43 µM 0.893324753059409 0.234400284739458 no 808 0.185841642959725 216 17201110 SGTC_1080 nisoldipine 24.4 µM 0.893273842630977 0.234413381163707 no 809 0.185855271108714 210 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_291 SEC14.278 35.5 µM 0.892343013834259 0.23465290305287 no 810 0.186104552759097 201 1068044 SGTC_1377 2944-0135 198 µM 0.890846504042624 0.235038270144473 no 811 0.186505761447091 192 1894137 SGTC_2826 7992541 19.48 µM 0.89075352464035 0.235062224854238 no 812 0.186530706539895 260 2985066 SGTC_302 1094-0063 18.9 µM 0.88975955027109 0.235318391283185 no 813 0.186797505262951 226 5440289 SGTC_2755 lomerizine 42.69 µM 0.889388921943118 0.235413948805776 no 814 0.186897048297023 199 3949 A calcium channel blocker. SGTC_2483 5729050 27.16 µM 0.88915306389011 0.235474770231495 no 815 0.186960411935458 209 2865180 SGTC_2889 9059656 51.95 µM 0.887876462480306 0.235804121711821 no 816 0.187303603533973 211 3949838 SGTC_1975 st070967 30.8 µM 0.88774663347503 0.235837630629103 no 817 0.187338527560618 236 261391 SGTC_791 1348-1292 225 µM 0.885900082573271 0.23631451022299 no 818 0.18783568581904 215 5437054 SGTC_2321 7390090 138.78 µM 0.884232330982904 0.236745670050891 no 819 0.188285404391093 184 649046 SGTC_571 k831-0106 44.2 µM 0.883994026578747 0.236807313626199 no 820 0.188349718708701 222 4783639 SGTC_2023 5144124 124 µM 0.883542239468339 0.23692420422929 no 821 0.188471685582627 222 2830192 SGTC_1581 himbacine 57.9 µM 0.883137855107852 0.237028857243099 no 822 0.188580896655571 215 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2475 5812728 15.03 µM 0.882181524159746 0.237276452822132 no 823 0.188839325767466 207 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_336 4111-0029 111 µM 0.882146108658119 0.237285624677699 no 824 0.188848900279686 202 3131175 SGTC_2942 9052777 62.25 µM 0.880633699783759 0.237677487799391 no 825 0.189258056198761 252 6469503 SGTC_2838 9002687 71.43 µM 0.880096297686161 0.237816813411034 no 826 0.189403572308159 222 6457060 SGTC_3146 9095609 49.47 µM 0.879948749881802 0.237855074145679 no 827 0.189443536900317 215 17173999 SGTC_895 0964-0006 13.7 µM 0.878910788946675 0.238124323968722 no 828 0.18972482418858 243 6738897 SGTC_2636 apigenin dimethyl ether 100 µM 0.876637072126395 0.238714715381469 no 829 0.190341898229383 214 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1666 st014829 29 µM 0.875778937778807 0.238937745829423 no 830 0.190575111158518 207 3858230 SGTC_1914 st062367 72.6 µM 0.874381342109312 0.23930122688732 no 831 0.190955307376421 220 978205 SGTC_1661 st013063 9.66 µM 0.871725486592143 0.239992782737896 no 832 0.191679076444829 234 721395 SGTC_2403 6032726 181.2 µM 0.871320811893493 0.240098251214519 no 833 0.191789504993834 206 2881040 SGTC_2424 5537928 59.2 µM 0.87103782721594 0.240172019198953 no 834 0.191866749632875 234 5382802 SGTC_1342 1486-1464 234 µM 0.870589817638105 0.240288830859789 no 835 0.191989079071178 229 3253938 SGTC_949 1165-0505 146 µM 0.870140503826421 0.240406013663407 no 836 0.192111812562121 221 6244267 SGTC_2328 6201408 200 µM 0.869759500284616 0.240505405264362 no 837 0.19221592418635 231 2890418 SGTC_2703 st077852 53.4 µM 0.868770737347416 0.240763446146745 no 838 0.192486270866746 228 6281836 SGTC_417 st075190 100 µM 0.867932599008283 0.240982295931681 no 839 0.192715615843599 230 222757 SGTC_1202 1988-0068 29.6 µM 0.86732694873064 0.241140507103936 no 840 0.192881447552224 207 2850480 SGTC_2019 4016004 108 µM 0.866749047922725 0.241291522041874 no 841 0.193039762479435 226 45595336 SGTC_3003 9075612 71.4286 µM 0.866329349677683 0.241401228267412 no 842 0.193154787809128 238 6501993 SGTC_2920 7982904 15.77 µM 0.86522107012627 0.241691055100314 no 843 0.193458731432612 212 6456808 SGTC_3112 9123419 49.47 µM 0.862591629635453 0.242379436649453 no 844 0.19418101705854 238 17015854 SGTC_1268 0828-0275 2.46 µM 0.860568086040558 0.242909918251132 no 845 0.194737984622909 221 745337 SGTC_3001 9076041 71.4286 µM 0.860075477395045 0.243039152965309 no 846 0.194873718979657 208 16004211 SGTC_2833 9001315 45.46 µM 0.860065298290195 0.243041823821511 no 847 0.194876524356862 207 2989378 SGTC_2181 6316240 54.2555 µM 0.859881348821099 0.243090092351216 no 848 0.194927225350218 213 12779990 SGTC_2071 5230951 39.92 µM 0.859878740955106 0.243090776695199 no 849 0.19492794419982 231 1799272 SGTC_2777 climbazole 1.536 µM 0.858618403992668 0.243421630307601 no 850 0.195275540513936 231 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1836 st055642 81 µM 0.858295293732511 0.243506489802739 no 851 0.195364713755548 240 8571 SGTC_3144 9087057 49.47 µM 0.854403453887638 0.244529870615354 no 852 0.196440741436435 203 17249618 SGTC_1699 st031318 29.054 µM 0.853156332436617 0.244858297584809 no 853 0.1967863078094 229 5340658 SGTC_326 k292-0812 17.5 µM 0.851782857110144 0.245220274122528 no 854 0.197167311393321 217 3579357 SGTC_2226 7298446 200 µM 0.851593555240429 0.245270186783112 no 855 0.197219858918482 209 3283010 SGTC_831 k061-1017 217 µM 0.849878799190283 0.245722560110925 no 856 0.197696236851444 234 1240153 SGTC_3288 9119690 36.221 µM 0.849618918797517 0.245791158764438 no 857 0.19776849509381 230 17595618 YKL019W RAM2 SGTC_2001 4023502 57.655 µM 0.84738776693554 0.246380521758112 no 858 0.198389510387043 200 108941 YCR052W RSC6 SGTC_301 4119-0100 24.5 µM 0.846284722039109 0.246672172706692 no 859 0.198696964350074 235 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3083 9117465 49.47 µM 0.846216077483764 0.246690328801951 no 860 0.19871610727929 231 16420915 SGTC_2245 6637752 200 µM 0.84543792231774 0.246896196454982 no 861 0.19893318940669 214 681890 SGTC_178 4092-0806 87.505 µM 0.845062364989018 0.246995586269102 no 862 0.199038009836625 222 2169044 SGTC_2555 cholic acid 100 µM 0.843986418571506 0.247280449865558 no 863 0.199338497491276 199 6708657 Influences liver metabolism. SGTC_1195 1502-0147 41.1 µM 0.842894204800903 0.24756979990353 no 864 0.199643807465831 205 817940 SGTC_1021 4476-0760 85.3 µM 0.842738716269733 0.247611006736791 no 865 0.199687294535625 194 746768 SGTC_2141 5621638 7.665 µM 0.842554101368478 0.247659937259457 no 866 0.199738935075573 225 2856238 SGTC_1550 gossypolone 36.6 µM 0.842359834083321 0.247711431635558 no 867 0.19979328425766 230 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_379 3970-0972 5.9 µM 0.840727070286953 0.248144453766106 no 868 0.200250425854102 229 2898042 YBL034C STU1 SGTC_2737 bleomycin 30.5 nM 0.839117651032726 0.248571679540714 no 869 0.200701645991653 233 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1243 0416-0003 5.65 µM 0.838871095650381 0.248637163095492 no 870 0.20077082464448 217 2141977 SGTC_1680 diphenhydramine 100 µM 0.837749813582723 0.24893508442059 no 871 0.201085615118273 225 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2232 chlorophetanol 41.5365 µM 0.834428002921794 0.249818793613443 no 872 0.202019921382233 230 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1613 st002381 52.1 µM 0.834226194534358 0.24987253479268 no 873 0.202076766440046 225 551167 SGTC_724 3910-0327 137 µM 0.834031721572487 0.24992432836804 no 874 0.202131554322525 242 2885483 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.833465947312347 0.250075042233932 no 875 0.202290997573911 233 229346 A bile salt which induces apoptosis. SGTC_304 1310-0298 97 µM 0.831763985079795 0.250528710243501 no 876 0.202771088112249 259 1550234 SGTC_1854 st056233 32.9 µM 0.830936169615606 0.250749526836979 no 877 0.203004844674747 235 5393174 SGTC_1376 2910-0861 41.3 µM 0.830232087080418 0.250937419220665 no 878 0.203203788410538 237 1112859 SGTC_2812 7970281 58.44 µM 0.822382344056234 0.253037248122795 no 879 0.205429662395221 227 2233435 SGTC_1527 coumarin 137 µM 0.821957443529556 0.253151173402419 no 880 0.205550558904437 242 323 A hepatotoxic, DNA x-linker. SGTC_789 1309-1135 70.6 µM 0.821693913660111 0.253221845172789 no 881 0.205625562005556 209 3092424 SGTC_2092 5303694 80.6725 µM 0.821485861008008 0.2532776467422 no 882 0.20568478723816 230 1963699 SGTC_1687 st020778 55.3625 µM 0.821400817494596 0.253300458029277 no 883 0.205708999033736 223 4259299 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.82125291114997 0.253340133634612 no 884 0.205751111837605 258 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1706 st031321 9.9705 µM 0.821120397093375 0.25337568306132 no 885 0.205788846399416 229 6103185 SGTC_3338 9144300 39.5675 µM 0.819768923608484 0.253738391316889 no 886 0.206173924998945 201 4901274 SGTC_1857 st056007 79.3 µM 0.819639030229016 0.253773266438248 no 887 0.206210958321528 216 619834 SGTC_262 fenpropimorph 62.5 µM 0.819458953071 0.253821619583462 no 888 0.206262305839832 238 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2972 9093619 59.92 µM 0.819004636604621 0.253943631170642 no 889 0.206391884111742 211 25236256 SGTC_2917 7979103 53.79 µM 0.817866349655714 0.254249465518392 no 890 0.206716753381856 208 2980565 SGTC_1840 st055363 71 µM 0.817800425767239 0.254267183828901 no 891 0.206735577456436 239 676033 SGTC_1141 3253-0389 52.6 µM 0.817484862965901 0.254352006354667 no 892 0.206825698115977 244 5402031 SGTC_578 3460-0051 92 µM 0.817464824932075 0.254357393030972 no 893 0.206831421504708 262 2876744 SGTC_526 4469-0568 170 µM 0.817136381343711 0.254445694611393 no 894 0.206925246981396 217 2901964 SGTC_2621 lithochol-11-enic acid 100 µM 0.816578990033006 0.254595585208039 no 895 0.207084532889097 232 6708711 SGTC_3098 9119039 49.47 µM 0.81362508708554 0.255390703863499 no 896 0.20792988081233 225 17161528 SGTC_2452 5863136 48.41 µM 0.813014933000227 0.255555104034536 no 897 0.208104748263722 240 2184096 SGTC_2290 7904846 200 µM 0.811229587015539 0.256036465742555 no 898 0.208616918797499 227 2962154 SGTC_1645 Cervolide 78 µM 0.81105581743999 0.25608334242144 no 899 0.20866680853737 244 23173 A fragrance. SGTC_1326 1431-2094 10.8 µM 0.809562102956578 0.256486476527893 no 900 0.209095948177737 241 616278 SGTC_2369 9071472 200 µM 0.808174445211149 0.256861283328036 no 901 0.20949508330573 233 17296037 SGTC_1573 oleylamine 1.06 µM 0.807959582508398 0.256919343286007 no 902 0.209556924798855 247 5356789 An amine of the fatty acid oleic acid. SGTC_882 0843-0131 351 µM 0.807951930755796 0.256921411059905 no 903 0.209559127313955 246 5425421 SGTC_3310 9130229 44.1445 µM 0.805397358368108 0.257612230488829 no 904 0.210295207827703 220 7761258 SGTC_2487 5918373 44.05 µM 0.803492134697959 0.258128077238473 no 905 0.210845170513067 251 2876279 SGTC_1614 st002383 48.6 µM 0.802612931558383 0.258366305400224 no 906 0.211099245829361 217 1947235 SGTC_3250 9135583 49.47 µM 0.8020627680307 0.258515435184565 no 907 0.21125832531815 217 7699353 SGTC_320 4092-0846 5.34 µM 0.802015392301741 0.258528279145858 no 908 0.211272027268363 236 1359356 SGTC_2941 9056145 11.23 µM 0.801029755596813 0.258795568545343 no 909 0.211557209979719 227 2119517 SGTC_2284 7945075 39.21 µM 0.800558054166762 0.258923537241907 no 910 0.211693771095134 254 1245402 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.799490345803524 0.259213318547361 no 911 0.212003071195294 248 4620898 SGTC_982 1491-0518 27.5 µM 0.797496799853963 0.259754825068884 no 912 0.212581280331229 230 3091256 SGTC_3276 9139060 49.47 µM 0.797364237340385 0.259790853688982 no 913 0.212619761464847 266 4870619 SGTC_714 4296-0578 26.1 µM 0.793067131597294 0.260960141353261 no 914 0.213869355722331 247 1589775 SGTC_820 1582-0060 59.9 µM 0.790107948221513 0.261766936936859 no 915 0.214732364219038 239 3848840 SGTC_1951 sophoraflavanone G 9.2 µM 0.787322416656204 0.262527555340819 no 916 0.215546575203031 230 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2960 9079389 5.97 µM 0.786118961674354 0.2628565208615 no 917 0.215898898275057 218 16457355 SGTC_3016 9080866 49.47 µM 0.786068509476808 0.262870316618124 no 918 0.215913675927817 236 17066299 SGTC_1170 0310-0127 64.8 µM 0.785391001689821 0.263055611655336 no 919 0.216112177472419 258 774975 SGTC_1194 1488-0194 225 µM 0.784169461449366 0.263389865471853 no 920 0.21647034085944 239 1391452 SGTC_3066 9117245 49.47 µM 0.780706666884448 0.264338577779824 no 921 0.217487519292126 235 17176980 SGTC_2521 angolensin 13.4 µM 0.780131171584126 0.264496416390309 no 922 0.217656835103688 251 821428 A flavenoid. SGTC_159 3970-0959 50 µM 0.777012421269522 0.265352615927925 no 923 0.218575720993131 247 6615653 SGTC_2987 9018338 71.43 µM 0.77666917432638 0.265446934362485 no 924 0.218676989025871 260 5055682 SGTC_1590 st077108 57.8 µM 0.776572688767497 0.265473450019138 no 925 0.218705459990393 219 5489485 SGTC_1334 1486-0610 236 µM 0.774290236034076 0.266101093393708 no 926 0.219379588195297 231 3742339 SGTC_1513 0337-0559 19 µM 0.773809487066923 0.266233388546793 no 927 0.219521730699472 244 775073 SGTC_2162 5663267 200 µM 0.773662910030571 0.266273731046376 no 928 0.2195650794877 246 6456493 SGTC_2241 6772625 37.8075 µM 0.773608686439006 0.266288655827148 no 929 0.219581116853709 241 2285411 SGTC_76 0433-0009 400.328 µM 0.773336519277849 0.266363574914572 no 930 0.219661624162479 235 2841569 SGTC_2105 5350118 200 µM 0.767252047814397 0.268041218767582 no 931 0.221465836397523 243 2133313 SGTC_2655 perillic acid 100 µM 0.765951527729287 0.268400494079299 no 932 0.221852572214381 256 5702197 An apoptosis inducer. SGTC_3101 9120531 49.47 µM 0.765422369584949 0.268546745999057 no 933 0.222010038369506 257 24824904 SGTC_2747 doxorubicin 7.63 µM 0.764328004448957 0.268849340270968 no 934 0.222335900412193 199 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_84 0443-0269 128.823 µM 0.761631853207563 0.269595561605512 no 935 0.223139879069536 237 6150058 SGTC_121 0557-0495 61.343 µM 0.761286193887169 0.269691305701821 no 936 0.223243072501709 271 3104427 SGTC_3052 9092717 49.47 µM 0.76109151291443 0.26974523783657 no 937 0.22330120468341 260 25237534 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.760130863428051 0.27001144396972 no 938 0.223588182915016 262 2346 DNA damaging agent; causes G2/M arrest. SGTC_3296 9122258 64.045 µM 0.759803826572703 0.270102099326521 no 939 0.223685927632294 233 4730474 SGTC_57 miconazole 162.5 nM 0.755817061871467 0.271208462249518 no 940 0.224879442829865 244 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1016 4226-1401 38 µM 0.753164094731381 0.271945934255207 no 941 0.225675656271149 259 2901613 SGTC_586 0957-0265 8.15 µM 0.751692886764018 0.272355330263796 no 942 0.226117884542443 249 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1771 st048882 4.1505 µM 0.751022801781668 0.272541897591684 no 943 0.226319466633305 250 4580403 SGTC_2835 9006588 71.43 µM 0.749029871160942 0.273097150786456 no 944 0.226919600745059 226 2345538 SGTC_983 1491-0821 12.2 µM 0.749008672403245 0.273103060014261 no 945 0.226925989178707 247 46495113 SGTC_1234 0326-0494 15.5 µM 0.748018083281695 0.273379260839944 no 946 0.227224625091614 267 1547813 SGTC_354 2783-3500 4.88 µM 0.747119887057216 0.273629819745313 no 947 0.22749559839794 253 6740761 SGTC_1449 4112-4002 201 µM 0.74686059261267 0.273702173100835 no 948 0.22757385776459 251 2059539 SGTC_1474 0330-0125 5.35 µM 0.746092630862394 0.273916520162703 no 949 0.227805730279877 256 X1474 SGTC_1438 4092-1045 4 µM 0.744677632642478 0.274311679813671 no 950 0.22823331202402 273 1351342 SGTC_1783 st039459 87.517 µM 0.74465886580194 0.274316922628307 no 951 0.22823898598567 276 729761 SGTC_2259 7964009 200 µM 0.744132799224509 0.274463907799914 no 952 0.228398069078434 240 313134 SGTC_2877 9040724 71.43 µM 0.743467304688914 0.274649905383438 no 953 0.228599404569562 242 6463895 SGTC_3206 9114350 49.47 µM 0.742719350514435 0.274859023597294 no 954 0.228825805922373 243 17087243 SGTC_2813 7971799 71.43 µM 0.741615760219123 0.275167716270761 no 955 0.229160085985013 243 2234054 SGTC_1311 1190-0148 100 µM 0.741290323511555 0.275258778945049 no 956 0.229258713783531 259 1961333 SGTC_2854 9024559 71.43 µM 0.73936826405611 0.275796905901198 no 957 0.229841703874056 256 3163529 SGTC_99 0109-0120 622.8 µM 0.739288210542959 0.27581933002472 no 958 0.229866003322951 271 759414 SGTC_874 0599-0792 117 µM 0.737987690081511 0.276183749683058 no 959 0.230260964803378 257 765305 SGTC_2378 9074213 121.43 µM 0.736693140778976 0.276546730688232 no 960 0.23065448951894 263 657714 SGTC_1839 st053978 48 µM 0.735957815088805 0.276753014076634 no 961 0.230878185380574 252 3788398 SGTC_913 3487-1245 167 µM 0.73372046659239 0.277381128209527 no 962 0.231559561069285 252 4016153 SGTC_3048 9093155 49.47 µM 0.73369960872955 0.27738698713208 no 963 0.23156591851862 242 25236002 SGTC_2943 9068529 45.32 µM 0.733441178083439 0.277459584685812 no 964 0.231644695911935 279 3270634 SGTC_1247 0448-0043 5.84 µM 0.733382900609303 0.277475957100411 no 965 0.231662462693281 259 3089013 YGL099W LSG1 SGTC_2653 dihydrofissinolide 100 µM 0.732101307986767 0.277836125761863 no 966 0.232053367769717 257 6857746 SGTC_3130 9127414 49.47 µM 0.730831646231341 0.278193166381627 no 967 0.232440995585531 265 1494646 SGTC_380 3970-0968 6 µM 0.730327724125288 0.278334935933448 no 968 0.232594942807365 250 2891601 SGTC_2643 anethole 100 µM 0.729607077878631 0.278537738149818 no 969 0.232815197292328 277 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1612 st002233 45.4 µM 0.727765753455561 0.279056245106598 no 970 0.233378495881415 256 1035021 SGTC_2017 5132927 60.65 µM 0.727018299828997 0.279266857845853 no 971 0.23360737274399 247 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1615 st002656 86.5 µM 0.725334036647043 0.279741721783035 no 972 0.234123564834006 245 1584458 SGTC_406 estrone 100 µM 0.724647589354836 0.279935372179712 no 973 0.234334127869162 255 5870 A steroid. SGTC_822 1487-0950 154 µM 0.723989472223049 0.280121091502245 no 974 0.234536099191463 239 1958375 SGTC_2343 7990716 14.84 µM 0.721822166554415 0.280733122530067 no 975 0.235201909634007 277 6456862 SGTC_1292 0kpi-0043 232 µM 0.718739936917288 0.281604633601494 no 976 0.236150585703737 264 3333905 SGTC_2446 5162541 200 µM 0.718511446393158 0.281669291998187 no 977 0.236220996370131 265 1549321 SGTC_1896 st058441 89 µM 0.717643936269361 0.281914845735453 no 978 0.236488429846263 249 688759 SGTC_1961 st076550 68.7 µM 0.716148654603387 0.282338335748203 no 979 0.236949781770879 277 1579337 SGTC_650 1328-0195 38 µM 0.714575461029605 0.28278422190924 no 980 0.237435706112112 281 2780821 SGTC_199 4063-0024 41.6 µM 0.714480182485811 0.282811237319392 no 981 0.23746515308463 257 306215 SGTC_2125 5246583 200 µM 0.714073301374049 0.282926618902016 no 982 0.237590927112278 270 835267 SGTC_244 nsc-207895 1.295 µM 0.713594914368145 0.283062306719996 no 983 0.237738851601563 227 42640 SGTC_1958 st076513 41.9 µM 0.712468655678612 0.283381877589318 no 984 0.238087307195643 270 732122 YGL099W LSG1 SGTC_1805 st050013 60.3 µM 0.711612231578916 0.283624999819361 no 985 0.238352465322213 259 4037144 SGTC_431 k089-0097 107 µM 0.710544742462127 0.283928179146726 no 986 0.238683197754226 267 5499420 SGTC_3120 9124077 49.47 µM 0.709606079908759 0.284194898315201 no 987 0.238974224144225 278 18774327 YGL155W CDC43 SGTC_462 ag-879 158 µM 0.708765940538032 0.284433723862646 no 988 0.239234868498092 290 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_998 3996-0085 177 µM 0.704287895603336 0.285708308018353 no 989 0.240626751430417 271 715391 SGTC_1428 4049-0204 61.7 µM 0.70410591501325 0.285760162483894 no 990 0.24068340839151 282 X1428 SGTC_481 bay k-8644 50 µM 0.703661957376891 0.285886684785839 no 991 0.240821658483959 281 2303 A calcium channel antagonist. SGTC_2725 haloperidol 53.21 µM 0.702153032643844 0.286316908196701 no 992 0.241291866189777 268 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1720 st037298 9.481 µM 0.700788312793516 0.286706280543446 no 993 0.241717566381726 281 597396 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.69746158613612 0.287656489465166 no 994 0.242756985709298 271 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1872 amphotericin b 148 nM 0.695663615719446 0.288170660392569 no 995 0.243319758191944 261 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2778 tioconazole 65.09 nM 0.694723767354181 0.288439604064755 no 996 0.243614215156568 275 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2170 morpholine 200 µM 0.69345581464267 0.288802624267247 no 997 0.244011772806016 267 121171 Reacts with secondary amines. SGTC_171 k064-0041 9.68 µM 0.692868068315617 0.288970971442268 no 998 0.244196175175179 262 53325 SGTC_2589 lobaric acid 100 µM 0.691975337617558 0.289226763054993 no 999 0.244476408485572 277 73157 A novel microtubule depolymerizer. SGTC_1953 st076800 12.1 µM 0.69178848978387 0.289280313505252 no 1000 0.244535083015884 268 297591 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.691524557335521 0.289355964287919 no 1001 0.244617976817085 269 115019 SGTC_1897 st060201 15 µM 0.690202188487545 0.289735133883766 no 1002 0.245033523648004 278 611878 SGTC_1901 st060216 58.6 µM 0.689946831362775 0.289808380590896 no 1003 0.245113811883669 264 688792 SGTC_2876 9059903 25.97 µM 0.689041175932872 0.290068229055869 no 1004 0.245398678019715 260 6916095 SGTC_1999 st074831 12.5 µM 0.683459383733196 0.29167214890015 no 1005 0.247158303452739 290 17112523 SGTC_749 1000-0129 128 µM 0.681776845594795 0.292156433377178 no 1006 0.247690033742966 276 708470 SGTC_927 2425-1185 123 µM 0.67867141229322 0.293051250611603 no 1007 0.248673041835258 287 730375 SGTC_616 4092-0450 108 µM 0.678659910420525 0.293054567188539 no 1008 0.248676686548868 299 787165 SGTC_1122 capsaicin 818.572 nM 0.677922706069646 0.293267177140812 no 1009 0.248910351214062 276 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3006 9075424 71.4286 µM 0.676634032819208 0.293639002514175 no 1010 0.249319090256577 271 7465181 SGTC_483 fpl-64176 144 µM 0.676380615929264 0.293712147440046 no 1011 0.249399510530236 285 3423 SGTC_636 0kpi-0074 126 µM 0.675600421308732 0.293937391661026 no 1012 0.24964718698201 287 616434 SGTC_1365 1672-3266 55.4 µM 0.674332993772929 0.294303471477744 no 1013 0.250049816152191 277 6415873 SGTC_2333 9017922 200 µM 0.6740270041233 0.294391884118133 no 1014 0.250147072806586 291 3163164 SGTC_2244 6635614 200 µM 0.673762083933552 0.294468440052853 no 1015 0.250231292025373 284 836499 SGTC_2095 5432005 200 µM 0.673514691175329 0.29453993925287 no 1016 0.250309952776407 297 783734 SGTC_2762 leflunomide 42.06 µM 0.669218487629246 0.295782864299921 no 1017 0.251678057313319 300 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1466 k213-0079 57.5 µM 0.667962581741969 0.296146662265562 no 1018 0.252078738951656 304 3657981 SGTC_2002 4023503 131 µM 0.665745597775219 0.296789356052293 no 1019 0.252786861480593 306 4736863 YCR052W RSC6 SGTC_1673 st016611 27.3 µM 0.66485467192909 0.297047811213459 no 1020 0.253071725092841 297 5226799 SGTC_2809 7964133 12.99 µM 0.664546343617389 0.297137280386512 no 1021 0.253170348955232 296 1253665 SGTC_1335 1486-0900 202 µM 0.664244518661805 0.297224874379372 no 1022 0.253266912187678 278 X1335 SGTC_1051 3253-3903 78 µM 0.664045394627978 0.29728266953139 no 1023 0.253330628787367 285 5509239 SGTC_224 benfluorex 43.875 µM 0.663654244471851 0.297396214636956 no 1024 0.253455815295338 296 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1411 3909-8223 150 µM 0.662834294078288 0.297634298371573 no 1025 0.253718343576376 287 X1411 SGTC_2386 9075165 157.42 µM 0.661900662303467 0.297905496900125 no 1026 0.254017443653487 277 16452277 SGTC_114 0364-0001 490.298 µM 0.661860409577384 0.297917191923046 no 1027 0.254030343253126 287 4003655 SGTC_2091 4-phenylthiadiazole 200 µM 0.66176537945633 0.297944802795064 no 1028 0.254060798467339 281 270010 SGTC_134 0269-0018 6.916 µM 0.65972946486686 0.298536614987866 no 1029 0.25471372735226 286 4378915 SGTC_1725 st036284 20.55 µM 0.65929062457844 0.298664249805562 no 1030 0.254854580839408 281 707914 SGTC_3220 9131269 49.47 µM 0.657872866720652 0.299076768060347 no 1031 0.255309913553201 287 17722206 SGTC_3005 9076496 71.4286 µM 0.657621364918452 0.299149973348007 no 1032 0.255390731252029 286 21368410 SGTC_2489 cantharidin 73.42 µM 0.656856612496715 0.299372621783112 no 1033 0.255636559240757 284 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1144 3486-0183 12.5 µM 0.656806628530342 0.299387176627582 no 1034 0.255652630778402 310 6744069 SGTC_851 0394-0702 453 µM 0.656663823905237 0.299428761712316 no 1035 0.25569855020779 297 762646 SGTC_5 0352-0601 109.883 µM 0.655953948671483 0.29963551811537 no 1036 0.255926877480238 281 762456 SGTC_1368 1852-0141 284 µM 0.655458234593467 0.29977993684486 no 1037 0.256086384116266 302 2838987 SGTC_2821 7996764 71.43 µM 0.654287733081829 0.3001210696112 no 1038 0.256463223741652 239 2987135 SGTC_2388 9080168 200 µM 0.653529284494631 0.300342206731718 no 1039 0.256707558268609 304 15943073 SGTC_1301 naphtanilide LB 4.81 µM 0.653346186377357 0.300395602779871 no 1040 0.256766561558196 288 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1290 0986-0249 10.2 µM 0.653204462968289 0.300436935859773 no 1041 0.256812236712295 299 53329 SGTC_2793 7325131 81.82 µM 0.651115031733371 0.301046608241762 no 1042 0.257486116922698 280 4176441 SGTC_3251 9135047 49.47 µM 0.650800890094712 0.301138319418796 no 1043 0.257587512785923 266 17682963 SGTC_598 3937-0236 20.2 µM 0.650043033055202 0.301359621612975 no 1044 0.257832212512866 302 1379313 SGTC_532 1548-0774 215 µM 0.649472622176666 0.30152623584269 no 1045 0.258016468455264 313 5932993 SGTC_258 haloperidol 50.781 µM 0.649066155020198 0.301644988196548 no 1046 0.258147808434564 306 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3331 9141060 1.957 µM 0.648702759056873 0.301751174791368 no 1047 0.258265260346787 281 4906567 YPR165W RHO1 SGTC_1217 1183-1422 255 µM 0.648248362624904 0.301883975936292 no 1048 0.258412163155148 282 2849664 SGTC_2264 7948757 110.76 µM 0.647043761821844 0.302236157586608 no 1049 0.258801810555303 285 2971411 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.645656998264348 0.30264182517282 no 1050 0.259250757603746 277 688667 SGTC_2564 betulinic acid 100 µM 0.645194183139412 0.302777265973783 no 1051 0.259400677637131 302 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2334 9017922 200 µM 0.645068818461405 0.302813958064721 no 1052 0.259441294814039 300 3163164 SGTC_220 paclitaxel 373.376 µM 0.643577235540647 0.30325067148676 no 1053 0.259924807972226 280 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1477 0139-0234 16 µM 0.640857214693854 0.304047777343075 no 1054 0.260807727999419 291 620880 SGTC_1183 1254-0324 198 µM 0.640777979143483 0.304071011423623 no 1055 0.260833471004344 275 5799357 SGTC_61 0978-8327 98.565 µM 0.640048694236271 0.30428489531312 no 1056 0.26107047128082 304 6150059 YHR072W ERG7 SGTC_1874 staurosporine 7.6 µM 0.638935364891827 0.304611540481877 no 1057 0.261432490254087 287 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1994 st072947 40.9 µM 0.638173365537106 0.304835197081772 no 1058 0.261680416504027 306 5286565 YDL195W SEC31 SGTC_2756 carbadox 75.1 µM 0.638076725624315 0.304863567351727 no 1059 0.261711868156085 289 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_45 0kpi-0036 14.9 µM 0.635585855263726 0.305595208629309 no 1060 0.262523195609533 302 2795021 SGTC_1669 st015249 58.4 µM 0.635399744167746 0.305649906114704 no 1061 0.262583867451524 297 722793 SGTC_428 3448-4153 16.5 µM 0.634913216337511 0.305792915651175 no 1062 0.262742508435807 276 3834874 SGTC_194 1486-1323 56.904 µM 0.633657015100925 0.306162299205875 no 1063 0.263152341607217 294 5178754 SGTC_1546 5-methoxyflavanone 78.7 µM 0.630458609265904 0.307103673668329 no 1064 0.26419728757748 274 147795 SGTC_666 0272-0154 136 µM 0.630179073101464 0.307186009040804 no 1065 0.264288714703503 291 6870312 SGTC_3127 9126946 49.47 µM 0.629367267878892 0.307425175546113 no 1066 0.264554320904591 285 27243249 SGTC_1846 st056244 14.8 µM 0.629291937713594 0.307447372773017 no 1067 0.264578974290448 307 5393182 SGTC_113 0099-0221 2.5 µM 0.628784264614693 0.307596985083942 no 1068 0.264745151496994 291 89219 SGTC_684 1140-0066 328 µM 0.628766622596245 0.307602184798833 no 1069 0.264750927232774 293 6813534 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.625897950421852 0.308448195550823 no 1070 0.265690939480515 294 5106787 A p450 inhibitor. SGTC_1325 1431-0015 227 µM 0.625402265849229 0.308594483013368 no 1071 0.265853537694637 279 1103340 SGTC_3352 9151559 45.5865 µM 0.622158730483653 0.309552471008256 no 1072 0.266918749908541 277 17159339 SGTC_2149 5554786 194.827 µM 0.617540918841773 0.310918589924741 no 1073 0.268439000128015 299 745063 YPR165W RHO1 SGTC_250 brefeldin a 552.239 µM 0.616996296453576 0.311079881728557 no 1074 0.268618584274545 295 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_236 1509-0011 5.31 µM 0.616844488748894 0.311124846574243 no 1075 0.268668652205375 322 3107280 SGTC_3211 9128781 49.47 µM 0.615879364702222 0.311410778436375 no 1076 0.268987070869019 305 17194361 SGTC_593 1203-0218 61.7 µM 0.615536124588649 0.311512495691718 no 1077 0.269100360052119 312 3666956 SGTC_1737 st035557 69.7 µM 0.615511951801926 0.311519659701958 no 1078 0.26910833937879 303 5716916 SGTC_49 0717-0965 32.132 µM 0.612594013580354 0.312384963107208 no 1079 0.270072408765932 321 5889349 YGL099W LSG1 SGTC_440 fluspirilene 35.1 µM 0.611801187886683 0.312620251653514 no 1080 0.270334651853961 302 3396 An atypical antipsychotic. SGTC_3179 9107801 49.47 µM 0.610033104397038 0.313145244529585 no 1081 0.270919939231437 263 4818259 SGTC_1743 st037606 46.3785 µM 0.605664385557549 0.314444061459303 no 1082 0.272368819039034 270 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3231 9132313 49.47 µM 0.605578342471687 0.314469665153894 no 1083 0.27239739371922 305 4905967 SGTC_549 1661-1316 519 µM 0.60536791346163 0.314532285915996 no 1084 0.272467282907498 314 2857282 SGTC_830 4076-0286 57.8 µM 0.605128046061651 0.31460367364355 no 1085 0.272546960243367 298 6866659 SGTC_3047 9092122 49.47 µM 0.603037104280999 0.315226259030522 no 1086 0.273242002975325 305 17173831 SGTC_133 0724-0033 378.92 µM 0.602967162564306 0.315247093512835 no 1087 0.273265267227866 292 280309 SGTC_2457 5731572 11.68 µM 0.602258106226711 0.315458342850525 no 1088 0.273501171346125 326 2865357 SGTC_8 0354-0001 70 µM 0.601359380960733 0.31572618699493 no 1089 0.273800323389849 295 4993152 SGTC_1735 st034310 56.75 µM 0.599125211142225 0.31639244852727 no 1090 0.274544695396605 286 871153 SGTC_222 nsc-310342 10.666 µM 0.599004312055383 0.316428519400161 no 1091 0.274585004542025 312 432556 SGTC_3030 9087619 49.47 µM 0.597603188273018 0.31684667931044 no 1092 0.275052368179132 296 25236973 SGTC_29 0299-0004 12.984 µM 0.597148645235845 0.316982386216774 no 1093 0.275204071240822 289 16871 A napthoquinone isolated from Swertia calycina. SGTC_2107 5363541 170.161 µM 0.596908681756454 0.317054038872893 no 1094 0.275284175305297 294 244052 SGTC_2789 5281112 71.43 µM 0.596008762007795 0.31732281435329 no 1095 0.275584686658046 296 765948 SGTC_1682 st012968 530 nM 0.594739863624619 0.317701954936082 no 1096 0.276008685415849 295 24207270 SGTC_854 0422-0053 192 µM 0.594565453086462 0.317754082903897 no 1097 0.276066989229693 313 3596728 SGTC_2360 9040895 200 µM 0.594528225546962 0.317765209969972 no 1098 0.276079434831491 286 4914414 SGTC_953 1188-0045 9.7 µM 0.594045795292061 0.317909420074639 no 1099 0.276240741817693 320 6144426 SGTC_1386 3228-0095 33.8 µM 0.593592307099438 0.318045003879743 no 1100 0.276392413797531 313 870181 SGTC_3076 9116187 49.47 µM 0.591929246052188 0.318542434143604 no 1101 0.27694898433272 310 27241210 SGTC_1491 4138-0063 26.5 µM 0.59168417606465 0.318615763544642 no 1102 0.277031047370613 312 23883227 SGTC_2021 4019055 173 µM 0.589844163073583 0.319166555670356 no 1103 0.277647565749537 312 44827708 YER133W GLC7 SGTC_160 3453-0671 289.699 µM 0.58867430136256 0.319516951542429 no 1104 0.27803989014354 314 5322268 SGTC_3229 9132204 49.47 µM 0.585470849336167 0.320477270825699 no 1105 0.279115580953196 318 17682924 SGTC_2192 5915882 198.485 µM 0.584356861275101 0.320811500428354 no 1106 0.279490121859822 305 2876149 SGTC_111 0083-0039 52.457 µM 0.583678010415294 0.321015247173513 no 1107 0.279718482178835 304 759313 SGTC_2699 st077704 54.6 µM 0.582608850689471 0.321336248465073 no 1108 0.280078322946312 302 645852 SGTC_2215 7188065 200 µM 0.58241288272976 0.321395099778558 no 1109 0.280144303046604 312 940217 SGTC_2222 6885208 172.143 µM 0.582303614411045 0.321427916192479 no 1110 0.280181095670908 291 609514 SGTC_2988 9073640 71.4286 µM 0.581061344066141 0.32180110360482 no 1111 0.280599555157384 326 9102229 SGTC_973 1325-0077 65.9 µM 0.579868114919487 0.322159728012442 no 1112 0.281001779603309 313 2835149 SGTC_957 1187-1561 14.1 µM 0.579156826706866 0.322373584139366 no 1113 0.281241679517193 300 1538454 SGTC_1367 1812-0510 76.9 µM 0.578061104875218 0.322703139231934 no 1114 0.281611432769652 291 1142582 YDR527W RBA50 SGTC_231 b-estradiol 524 µM 0.575265623311061 0.323544553669482 no 1115 0.282555833517734 290 450 A steroid. SGTC_1591 genipin 88.4 µM 0.571846258563526 0.324574978901286 no 1116 0.283713067568339 320 442424 A DNA cross-linking agent. SGTC_2011 4012611 177 µM 0.571621377918609 0.324642793857559 no 1117 0.283789254616785 309 2049887 SGTC_467 ro 31-8220 72.8 µM 0.564763710376204 0.32671357334129 no 1118 0.286117246706165 329 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1444 4112-3581 28 µM 0.564705798820208 0.326731083503062 no 1119 0.286136944679327 308 2877249 SGTC_186 3455-3465 67.277 µM 0.563662308160629 0.327046659126429 no 1120 0.286491986784367 316 755278 SGTC_597 k018-0003 82.8 µM 0.563032889919421 0.327237069537794 no 1121 0.286706243984463 335 6786234 SGTC_1002 4049-0206 172 µM 0.557309333344132 0.328970607468728 no 1122 0.288658049957629 322 4662749 SGTC_293 4049-0273 38.5 µM 0.55643865668817 0.329234639902651 no 1123 0.288955509372971 307 1380311 SGTC_2208 7283366 200 µM 0.556261923282392 0.329288244660366 no 1124 0.28901590647103 326 898663 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.555518792057638 0.329513681124883 no 1125 0.289269930038972 335 61125 An anti-inflammatory. SGTC_3034 9090421 49.47 µM 0.553256376109728 0.330200389428235 no 1126 0.290043934043331 318 17173761 SGTC_1299 1079-1439 3.74 µM 0.553022530009985 0.330271401120733 no 1127 0.290123991376574 325 323161 SGTC_2476 5806916 10.51 µM 0.552887146591091 0.330312515593799 no 1128 0.290170344692594 309 2870194 SGTC_3058 9093861 49.47 µM 0.552800691128267 0.330338772250221 no 1129 0.290199947602613 330 17217477 SGTC_1324 1418-0026 34.4 µM 0.552567621187257 0.330409560109287 no 1130 0.290279759306705 314 1372513 SGTC_2648 atorvastatin 78.68 µM 0.550215705561024 0.331124221714428 no 1131 0.291085716280219 331 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3215 9129942 49.47 µM 0.547535277718717 0.331939456848425 no 1132 0.292005520468325 341 17682944 SGTC_1902 st060212 70.5 µM 0.546485094404772 0.332259080773827 no 1133 0.292366265481976 320 688944 SGTC_83 0170-0301 39.027 µM 0.544332567103391 0.332914585002175 no 1134 0.29310631999862 317 3089716 SGTC_2709 st078560 56 µM 0.543635462355946 0.333126982352262 no 1135 0.293346175779841 345 17250903 SGTC_2251 lansoprazole 556 µM 0.543067730389507 0.333300001317465 no 1136 0.293541584896706 331 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_803 4488-1585 147 µM 0.541963673435199 0.33363656937886 no 1137 0.293921765572408 321 747204 SGTC_782 0083-0095 30.5 µM 0.539838003257501 0.33428494978247 no 1138 0.294654378051754 316 3591729 An indicator and reagent. SGTC_1707 st032323 6.317 µM 0.538932146808449 0.334561408191858 no 1139 0.294966837333321 304 3132057 YMR211W DML1 SGTC_256 clotrimazole 625 nM 0.538497057564517 0.334694225023356 no 1140 0.295116967983833 297 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3043 9092303 49.47 µM 0.537317042252924 0.335054544622618 no 1141 0.295524317721067 301 25236084 SGTC_1779 st039427 55 µM 0.536090245114111 0.335429310142529 no 1142 0.295948090800343 354 1124498 SGTC_1312 1218-2183 165 µM 0.534354519626267 0.335959824342254 no 1143 0.296548139388095 315 6744073 SGTC_1719 st032227 49.2 µM 0.533327876222724 0.336273765782016 no 1144 0.296903317060971 302 3125804 SGTC_2294 7971431 200 µM 0.533327598799878 0.336273850631715 no 1145 0.296903413064514 368 5741572 SGTC_395 anisomycin 6.25 µM 0.532871264511744 0.336413431631398 no 1146 0.297061349017108 350 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_275 trichlorophene 5.69 µM 0.530569564253657 0.337117806286196 no 1147 0.297858545662535 317 62616 SGTC_707 0865-0008 204 µM 0.530488787824459 0.337142536174622 no 1148 0.297886540386662 329 723043 SGTC_1364 1653-0028 37.6 µM 0.528045875694758 0.337890771366517 no 1149 0.298733747707931 316 5718652 SGTC_2908 7930301 100 µM 0.527681280967504 0.338002497478762 no 1150 0.298860283838502 308 2223178 SGTC_1093 fluphenazine 7.97 µM 0.527382238845523 0.338094146357626 no 1151 0.298964087477189 341 6602611 An atypical antipsychotic. SGTC_1044 1222-0021 1.78 µM 0.527259836548059 0.338131662347136 no 1152 0.299006580541418 314 4306703 SGTC_1187 1391-0724 117 µM 0.526238020585144 0.338444909001327 no 1153 0.299361420156047 333 6997986 SGTC_2842 9000675 19.48 µM 0.525469561667338 0.338680560515232 no 1154 0.299628403813393 320 2989072 SGTC_3176 9106582 49.47 µM 0.525101738549292 0.338793377550118 no 1155 0.29975623379608 306 17018027 SGTC_39 0986-0283 58.349 µM 0.52482507080491 0.338878245354605 no 1156 0.299852400721104 302 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2726 cimetidine 79.27 µM 0.524817878826891 0.338880451602273 no 1157 0.299854900766568 335 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_396 dithiazanine 1.25 µM 0.5243145146804 0.33903487986841 no 1158 0.300029901553246 308 10578 An antihelmenthic. SGTC_2618 avocadyne 43.43 µM 0.522901798958575 0.339468434659758 no 1159 0.300521296329781 334 3015189 SGTC_2043 5101342 149 µM 0.51837997196455 0.340857585455402 no 1160 0.302096592807469 337 678451 SGTC_226 1,3-diallylurea 8.28947 mM 0.516497882896953 0.341436420115203 no 1161 0.302753358604731 322 74537 YKL182W FAS1 SGTC_1693 xanthone 101.9 µM 0.515841154397347 0.341638484222715 no 1162 0.302982678203433 356 7020 An insecticide. SGTC_1307 1187-1599 12.2 µM 0.515492478932399 0.341745784139711 no 1163 0.303104461952086 340 1538471 SGTC_595 3909-8003 73.7 µM 0.515051624179446 0.341881469226098 no 1164 0.303258472990847 336 699517 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.514260908250873 0.342124884805907 no 1165 0.303534794392026 344 6710655 SGTC_3247 9135149 49.47 µM 0.512775773264183 0.342582249049942 no 1166 0.304054089226244 355 8934436 YOR116C RPO31 SGTC_3230 9131665 49.47 µM 0.512734919602653 0.342594833666609 no 1167 0.304068379782178 338 15943720 SGTC_2532 xanthone 78.9 µM 0.51248001045196 0.342673360168792 no 1168 0.304157553421097 324 7020 An insecticide. SGTC_148 3253-0744 288.01 µM 0.512088806966881 0.34279388629314 no 1169 0.30429442890709 327 6893655 SGTC_2619 obliquin 87.91 µM 0.51167769878512 0.342920562112474 no 1170 0.304438298261271 344 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1818 st052136 56.3 µM 0.509105882204289 0.343713422861293 no 1171 0.305339004479084 323 674169 SGTC_1082 camptothecin 424.86 nM 0.508582799169018 0.343874767500492 no 1172 0.305522344120287 336 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_995 3931-2021 34.6 µM 0.508579276832972 0.343875854059288 no 1173 0.305523578857976 332 730143 SGTC_2449 5812982 45.77 µM 0.506828133867758 0.344416200467468 no 1174 0.306137707132476 339 776185 SGTC_1957 st077035 62.4 µM 0.503765995924769 0.345361840736355 no 1175 0.307212912798102 341 705593 SGTC_2721 ifenprodil 61.44 µM 0.503722426753471 0.345375302621926 no 1176 0.307228223195582 336 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1173 0443-0020 122 µM 0.503294650860687 0.34550748605479 no 1177 0.307378563358623 343 5331295 SGTC_2600 tangeritin 87.95 µM 0.502674023293965 0.345699294456837 no 1178 0.30759673803367 349 68077 A bioactive flavone. SGTC_805 3852-0218 479 µM 0.502566646715288 0.34573248380705 no 1179 0.307634491977725 319 6615355 SGTC_2635 hydroquinidine 100 µM 0.50182914233249 0.345960473284451 no 1180 0.307893855883768 317 442912 An experimental heart treatment. SGTC_736 0958-0254 92.6 µM 0.501724612068193 0.345992791919275 no 1181 0.30793062462603 367 6812352 SGTC_2846 9008642 19.48 µM 0.499444365648665 0.346698076618138 no 1182 0.308733185481141 360 2992898 SGTC_1094 duloxetine 25.4 µM 0.499231322380648 0.346763998512458 no 1183 0.30880821544902 312 60834 A selective serotonin reuptake inhibitor. SGTC_3148 9097893 49.47 µM 0.497670955973251 0.347246963391406 no 1184 0.309357991255576 289 17174100 SGTC_2099 5377090 177.372 µM 0.496244724932693 0.347688627784623 no 1185 0.309860879749394 340 2243829 SGTC_2193 5925765 200 µM 0.495530720588526 0.347909812943047 no 1186 0.310112771184238 327 877370 SGTC_3341 9147222 25.867 µM 0.495352473071826 0.347965038758796 no 1187 0.310175668494804 345 1939759 SGTC_3182 9108849 49.47 µM 0.495349779147119 0.347965873432976 no 1188 0.310176619129161 315 17133045 SGTC_1552 6-methylflavone 10.6 µM 0.494566804451676 0.348208498190805 no 1189 0.310452969624366 349 689013 SGTC_674 0498-0004 451 µM 0.493254485808075 0.34861529303772 no 1190 0.31091639175061 332 4231473 SGTC_529 4076-0302 30.3 µM 0.49237229280157 0.348888854689971 no 1191 0.311228091313431 340 5816522 SGTC_26 0302-0163 425.158 µM 0.492358201397067 0.348893224970168 no 1192 0.311233071237781 361 3100915 SGTC_1502 4534-4282 27.7 µM 0.490853625802978 0.349359966288004 no 1193 0.311764989241044 372 3278949 SGTC_3093 9117344 49.47 µM 0.48734688213089 0.350448692893036 no 1194 0.31300626467391 327 24824913 SGTC_897 1000-0139 31.4 µM 0.487324550250821 0.350455630144763 no 1195 0.313014176263124 357 6151020 SGTC_1178 0988-0033 191 µM 0.486772923823886 0.35062700509621 no 1196 0.313209630110231 342 5392207 SGTC_64 000l-0018 272.079 µM 0.486488470119887 0.350715388814862 no 1197 0.313310439072121 340 6811119 SGTC_1007 4101-0031 70 µM 0.486268975085479 0.350783594495615 no 1198 0.313388236544685 370 1146276 SGTC_2254 7938975 95.19 µM 0.485031643119196 0.351168171780846 no 1199 0.313826949793149 340 2969277 SGTC_745 0469-0705 296 µM 0.484958187944201 0.351191007308712 no 1200 0.313853002633289 377 3486736 SGTC_1940 st075990 51.1 µM 0.484373888822347 0.351372671623324 no 1201 0.314060272970521 336 1084979 SGTC_713 1488-1073 324 µM 0.484327188896058 0.351387192553449 no 1202 0.314076841520698 368 3312542 SGTC_219 mitoxanthrone 164.414 µM 0.481122973396849 0.352384032098213 no 1203 0.315214550613818 342 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3080 9117754 49.47 µM 0.477769510095196 0.353428389940052 no 1204 0.316407132238457 362 9550191 SGTC_2468 5987765 72.9 µM 0.477254573521321 0.353588852927902 no 1205 0.316590427136178 341 26772094 SGTC_2461 5755302 26.15 µM 0.476274520722364 0.353894325907553 no 1206 0.316939407503272 371 2788904 SGTC_2108 5365811 200 µM 0.475800765772312 0.354042024486806 no 1207 0.317108162129772 316 780283 SGTC_3138 9097216 49.47 µM 0.47542947792426 0.354157793116475 no 1208 0.317240443893699 355 25237486 SGTC_1186 1319-0216 26 µM 0.474173850863062 0.354549401109994 no 1209 0.317687969377348 337 4565136 SGTC_164 4100-3994 89.624 µM 0.472626952046553 0.355032063062827 no 1210 0.318239675137831 381 4615967 SGTC_1518 st038567 90.8 µM 0.47208368086052 0.355201629299532 no 1211 0.318433530107761 361 77966 SGTC_1214 0358-0031 63.7 µM 0.471524835444859 0.355376086498136 no 1212 0.318632994298526 375 4301366 SGTC_633 0437-0093 97.7 µM 0.470890158295266 0.355574253175974 no 1213 0.318859588247561 355 2831118 SGTC_427 1354-0053 47.3 µM 0.466426263563552 0.35696912543421 no 1214 0.320455207972013 367 6813657 SGTC_37 0566-0070 1.56 µM 0.465633111791655 0.357217169320331 no 1215 0.32073906883647 374 1626686 SGTC_1648 st011736 69.8 µM 0.465024856239263 0.357407431148327 no 1216 0.320956828290813 344 2855514 SGTC_2903 5923464 63.88 µM 0.464333559200802 0.35762371132293 no 1217 0.321204391927544 347 2876576 SGTC_1944 st076371 56.9 µM 0.464183419814051 0.357670690191499 no 1218 0.321258169558604 340 24208455 SGTC_502 l-744,832 89.3 µM 0.460539969046706 0.358811391673868 no 1219 0.322564344676744 380 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1414 3917-0015 5.4 µM 0.459899875141209 0.359011924468595 no 1220 0.322794044917522 364 6618702 SGTC_439 amiodarone 34.4 µM 0.45966950497678 0.359084105848571 no 1221 0.322876730719828 375 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_771 0250-0039 27.3 µM 0.458917417042875 0.359319790927217 no 1222 0.323146735444338 374 3005115 SGTC_2911 7942208 15.64 µM 0.457645923247589 0.359718366215979 no 1223 0.323603422361809 325 1243384 SGTC_3143 9086658 49.47 µM 0.455977588993315 0.360241570583793 no 1224 0.32420304699006 357 25236626 SGTC_504 lovastatin 124 µM 0.454508604344362 0.360702473996983 no 1225 0.324731400181419 372 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_369 0957-0393 4.5 µM 0.453993535186046 0.360864128232388 no 1226 0.324916739930156 348 6997992 SGTC_1068 loratadine 26.9 µM 0.453789223005629 0.360928258410955 no 1227 0.324990270548361 362 3957 A H1 histamine antagonist. SGTC_2882 9058044 58.44 µM 0.451575814102231 0.361623260754796 no 1228 0.325787298436455 331 18076804 SGTC_2361 9034121 116 µM 0.451538034659375 0.361635127333413 no 1229 0.325800909388331 373 6496917 SGTC_931 2812-0076 566 µM 0.449443112076787 0.362293353583284 no 1230 0.326556018547857 362 3450959 SGTC_1770 st043884 66.3 µM 0.447964145555376 0.362758291413656 no 1231 0.327089536514572 350 670149 SGTC_1976 st070609 63.5 µM 0.446612481277606 0.363183386711239 no 1232 0.327577441116431 358 682556 SGTC_1651 st011928 86.1 µM 0.443584823004755 0.364136189318433 no 1233 0.328671390273881 355 720198 SGTC_1380 2291-0730 164 µM 0.442700734167172 0.36441457044471 no 1234 0.328991105676133 337 2999191 SGTC_1981 st071826 47 µM 0.441628821426474 0.36475218933034 no 1235 0.329378912183404 348 11838600 SGTC_2460 5552655 174.22 µM 0.441525691637658 0.364784677514975 no 1236 0.329416233121428 339 5401989 SGTC_3263 9137018 49.47 µM 0.440806061905478 0.365011403952251 no 1237 0.329676702316957 360 43844957 SGTC_123 0083-0120 66.675 µM 0.439505306345602 0.365421339532238 no 1238 0.330147718979973 360 16001701 SGTC_129 0088-0017 176.636 µM 0.438771521462319 0.365652661107972 no 1239 0.330413548735354 367 182446 SGTC_1424 4048-1941 275 µM 0.436282110651841 0.366437797569045 no 1240 0.331316029827798 388 X1424 SGTC_567 1080-0542 68.4 µM 0.43543432152507 0.366705310031454 no 1241 0.331623601205795 348 5950415 SGTC_1480 1070-0044 41.2 µM 0.430833662499972 0.368158134033474 no 1242 0.333294660582086 356 3124987 SGTC_1070 indatraline 8.81 µM 0.430825742062038 0.368160636830828 no 1243 0.333297540324497 385 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1337 1486-1011 40.3 µM 0.429698750161413 0.368516814582704 no 1244 0.333707396354133 357 X1337 SGTC_265 mycophenolic acid 32.932 µM 0.427453819463565 0.369226645394591 no 1245 0.334524407232323 362 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_682 0kpi-0099 17 µM 0.427056966184771 0.369352173996162 no 1246 0.334668918071108 379 1714895 YML126C ERG13 SGTC_766 1391-0721 126 µM 0.425440116741162 0.369863743267043 no 1247 0.335257933403705 384 1020919 YIL115C NUP159 SGTC_2558 carylophyllene oxide 100 µM 0.424948600977277 0.370019303983664 no 1248 0.335437072100679 359 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1073 triclabendazole 3.09 µM 0.42225235841534 0.370873020395535 no 1249 0.336420414100567 357 50248 An antihelmetic and likely tubulin inhibitor. SGTC_654 1124-0271 80.9 µM 0.421648091453577 0.371064437987222 no 1250 0.336640949130481 368 5403748 SGTC_1800 st050079 29.0735 µM 0.420690107832524 0.371367970085687 no 1251 0.336990692764162 371 3645560 SGTC_877 0771-0151 33.1 µM 0.42006793863819 0.371565144010766 no 1252 0.33721791175375 370 6166523 SGTC_2119 5528445 120.635 µM 0.4184566436033 0.372075941990219 no 1253 0.337806639853875 364 791935 SGTC_2804 7954240 19.48 µM 0.418298369351219 0.372126128803999 no 1254 0.337864490863037 353 828705 SGTC_1273 0849-0096 14.1 µM 0.417992082063646 0.37222325489496 no 1255 0.337976453168745 383 5286025 SGTC_1736 st036774 51 µM 0.417245339319411 0.372460086909781 no 1256 0.338249482572227 381 1272247 SGTC_2740 felodipine 17.08 µM 0.416952100510923 0.372553101795768 no 1257 0.338356721907605 386 3333 L-type calcium channel blocker SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.416676658540093 0.372640478323611 no 1258 0.33845746476711 381 551469 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.416503614784245 0.372695375135304 no 1259 0.338520761409268 375 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_700 3453-2283 142 µM 0.414327995251969 0.373385794133725 no 1260 0.339316957024528 355 565664 SGTC_2580 diallyl disulphide 81.36 µM 0.414300214544158 0.373394612798527 no 1261 0.339327128377066 342 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1257 0669-0121 16 µM 0.412555792275141 0.373948492128152 no 1262 0.339966048029266 375 4307855 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.411157621415474 0.374392619663158 no 1263 0.340478480305431 366 4330530 SGTC_2340 7987427 183.45 µM 0.410912068830133 0.374470636417056 no 1264 0.340568506237593 351 2239331 SGTC_1772 st048439 82.2 µM 0.410583750948063 0.37457495731868 no 1265 0.340688890261472 340 2927068 YDL195W SEC31 SGTC_2373 9071805 200 µM 0.408714962458081 0.375168927525937 no 1266 0.34137442603354 375 10149009 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.406712521579413 0.375805706057207 no 1267 0.342109571383364 404 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3163 9099914 49.47 µM 0.405856740070694 0.376077948885727 no 1268 0.342423932675837 396 16268368 SGTC_2956 9076196 2.52 µM 0.403582720114459 0.376801663790773 no 1269 0.343259797333107 383 16423868 SGTC_772 k072-0172 35.3 µM 0.401759219506264 0.377382312376096 no 1270 0.34393061860423 336 5861980 SGTC_2150 5556613 200 µM 0.401758609245736 0.377382506744927 no 1271 0.343930843186549 379 743190 SGTC_2646 retinol 96.75 µM 0.401429644056934 0.377487287137177 no 1272 0.344051913862977 385 445354 A vitamin A analog and teratogen. SGTC_2419 paclitaxel 166.5 µM 0.399937984985157 0.377962516179413 no 1273 0.344601096951144 390 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2820 7989630 71.43 µM 0.39982834325637 0.377997454336109 no 1274 0.344641476612768 350 2984098 SGTC_1382 3002-2117 298 µM 0.39958916400648 0.378073674054851 no 1275 0.34472956944686 399 1497314 SGTC_475 α-linolenic acid 10 µM 0.397312399858424 0.37879945214543 no 1276 0.345568552286462 362 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1887 st057648 70.8 µM 0.397223132686785 0.378827917117836 no 1277 0.345601462545332 391 688672 SGTC_2377 9073351 62.6 µM 0.396134903919781 0.379174977685591 no 1278 0.34600275519971 395 7337946 YHR072W ERG7 SGTC_2012 4023501 200 µM 0.396118523280685 0.379180202583763 no 1279 0.346008797008131 401 3477460 SGTC_1905 st060207 84.5 µM 0.394961594262108 0.379549281588395 no 1280 0.346435615918796 374 1948547 SGTC_3335 9143315 29.6265 µM 0.393610771577578 0.379980354701082 no 1281 0.346934213683203 353 4899691 SGTC_1437 4092-1038 11.6 µM 0.391647841048722 0.38060702875898 no 1282 0.347659217013436 380 3977136 SGTC_1297 1068-0111 14.1 µM 0.391503816895148 0.380653021454009 no 1283 0.347712433948279 376 767057 SGTC_2202 7226349 200 µM 0.391124891485712 0.380774035607097 no 1284 0.347852461244508 344 844334 SGTC_3199 9111318 49.47 µM 0.390663747300912 0.380921322999304 no 1285 0.348022899489936 379 8548020 SGTC_2829 7992743 58.44 µM 0.390313740086753 0.381033125259946 no 1286 0.348152282166646 363 16462845 SGTC_3298 9116858 71.43 µM 0.389377229301835 0.381332322262673 no 1287 0.348498556981662 403 2506942 SGTC_390 dec-rvkr-cmk 16.7 µM 0.385268409318917 0.382645846575754 no 1288 0.350019282087185 369 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2798 7813637 45.45 µM 0.384491560373007 0.38289434514581 no 1289 0.350307074971192 414 956368 SGTC_3079 9117512 49.47 µM 0.384315761218591 0.382950586501453 no 1290 0.350372213782655 422 7185044 SGTC_1708 st033234 31.827 µM 0.382927218246351 0.383394893355264 no 1291 0.350886864745856 358 674664 SGTC_3169 9102970 49.47 µM 0.382376880979104 0.383571033100464 no 1292 0.351090918092733 380 17027839 SGTC_2929 9013348 24.6 µM 0.374230270236625 0.386181215755817 no 1293 0.35411650254605 374 2995952 SGTC_464 bw-b 70c 158 µM 0.373131642703346 0.386533614618874 no 1294 0.354525234543235 411 5353454 SGTC_1866 st057638 64 µM 0.3708800486871 0.387256134446833 no 1295 0.355363437955315 395 688802 SGTC_2053 5265679 138 µM 0.370675434228777 0.38732181311505 no 1296 0.355439644771949 377 764595 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.367882238486651 0.388218715624286 no 1297 0.356480522289409 366 688664 SGTC_1283 0922-0125 16.4 µM 0.36659988924624 0.388630681419267 no 1298 0.356958745421362 389 3360884 SGTC_769 0302-0231 76 µM 0.365241100571298 0.389067340757177 no 1299 0.357465720271707 398 571869 YER009W NTF2 SGTC_1848 st056003 16.4 µM 0.365180731776383 0.389086744084776 no 1300 0.357488250193676 381 146492 SGTC_518 1021-0119 62.6 µM 0.364813259036377 0.389204860639165 no 1301 0.357625403482607 381 1097762 SGTC_1258 0671-0043 57.1 µM 0.364803770654522 0.389207910620008 no 1302 0.357628945112093 392 4298767 SGTC_3051 9093778 49.47 µM 0.362500194882211 0.389948582182853 no 1303 0.358489138962165 428 17217378 SGTC_1148 3909-7663 27.7 µM 0.361366810896368 0.390313147437364 no 1304 0.358912627566044 389 4084526 SGTC_2239 6685329 187.64 µM 0.360986524880319 0.390435492191512 no 1305 0.35905476022113 341 805680 SGTC_2415 st077333 57.7 µM 0.360961222372164 0.390443632842123 no 1306 0.359064217776437 442 2766255 SGTC_1461 k072-0203 53.8 µM 0.360446186005426 0.390609347446415 no 1307 0.359256746506422 376 5418714 SGTC_2836 9010338 19.48 µM 0.358797087739074 0.391140083645407 no 1308 0.35987344572787 368 2994051 SGTC_3096 9117468 49.47 µM 0.357903562030894 0.391427735531786 no 1309 0.360207742476261 392 41316311 SGTC_2691 st077356 60.2 µM 0.356382982902384 0.391917390576163 no 1310 0.360776885789535 402 2839272 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.356278799691909 0.391950945804017 no 1311 0.360815892223377 383 390807 SGTC_1333 1482-0047 286 µM 0.354461824675294 0.392536284385305 no 1312 0.361496404345659 414 3811116 SGTC_2291 7917025 104.35 µM 0.353836215525537 0.392737880745722 no 1313 0.361730815467103 377 2964612 SGTC_1668 st014914 51.6 µM 0.35280304758391 0.393070871879812 no 1314 0.362118049435307 392 2839556 SGTC_888 0916-0002 6.97 µM 0.352122606264192 0.393290221602999 no 1315 0.362373157698083 374 2802138 YIL048W NEO1 SGTC_2417 cerulenin 830 nM 0.351688389142607 0.393430215243207 no 1316 0.362535984555109 389 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1956 st077085 54 µM 0.349988976434552 0.393978246216417 no 1317 0.363173485318884 425 24208685 SGTC_201 4262-0159 12.803 µM 0.349903628425888 0.394005775008812 no 1318 0.363205511937116 412 1341029 SGTC_2359 9039622 200 µM 0.349060511068153 0.394277748896087 no 1319 0.363521940891911 402 6463596 SGTC_2652 actinonin 100 µM 0.348571431325092 0.394435540507857 no 1320 0.36370553928338 405 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1175 0741-0056 27.6 µM 0.348173727367476 0.394563864357162 no 1321 0.363854858683616 394 765927 SGTC_1390 3413-2614 145 µM 0.344786129871648 0.395657374919418 no 1322 0.365127580592575 417 3421432 SGTC_1583 clindamycin 39.6 µM 0.344209915822824 0.395843457833582 no 1323 0.365344212842464 408 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_55 0767-0285 6.563 µM 0.342271196993019 0.396469722955791 no 1324 0.36607340473595 412 3116166 SGTC_2236 dapsone 200 µM 0.340611336223568 0.397006120839232 no 1325 0.366698097093179 382 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2247 cerulenin 830 nM 0.339594688638813 0.3973347553178 no 1326 0.367080889265482 373 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_144 4161-2749 112.381 µM 0.33771466738695 0.39794266988637 no 1327 0.367789110271863 394 797501 YMR168C CEP3 SGTC_328 k915-0120 63.5 µM 0.336769724765464 0.398248315650499 no 1328 0.368145248697759 383 6624543 SGTC_147 4466-0538 29.23 µM 0.336469367214095 0.398345480682049 no 1329 0.368258473892226 369 6742687 YHR072W ERG7 SGTC_671 0560-0003 407 µM 0.335381006192748 0.398697615924222 no 1330 0.368668846994297 420 3238678 SGTC_1986 st071812 45 µM 0.335335780142565 0.398712250434878 no 1331 0.368685902995066 407 11838594 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.335013670186535 0.39881648478228 no 1332 0.368807387093894 374 66535 A nucleotide analog. SGTC_780 0109-0199 192 µM 0.33270057202848 0.399565211792756 no 1333 0.369680158854396 425 610414 SGTC_2769 toremifene 3.73 µM 0.330612330051819 0.400241472549416 no 1334 0.37046866573757 391 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1207 2099-0101 141 µM 0.329715450963378 0.400532011768746 no 1335 0.370807488923917 389 5837381 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.328480938479056 0.400932015530848 no 1336 0.371274027178761 394 75037 A free radical scavenger. SGTC_3082 9117008 49.47 µM 0.327906357071588 0.401118225468065 no 1337 0.371491233503698 384 41448529 SGTC_2675 theaflavin digallate 100 µM 0.327864367294231 0.401131834366808 no 1338 0.37150710830858 387 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2845 9003024 42.97 µM 0.32714442456627 0.401365186656157 no 1339 0.371779326398768 377 2990173 SGTC_1132 3456-3614 2.5 µM 0.326453427773974 0.401589189901712 no 1340 0.372040660027384 385 3125502 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.326169074987729 0.401681379099839 no 1341 0.372148218821465 386 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2152 5568786 200 µM 0.325664830154893 0.40184487231723 no 1342 0.372338978127761 429 5399883 SGTC_101 0490-5701 117.494 µM 0.324448708921157 0.402239250550518 no 1343 0.3727991740038 415 4661669 SGTC_1849 st056239 19.2 µM 0.321741737148968 0.403117456316189 no 1344 0.37382417800341 427 5393181 SGTC_1035 k081-0041 55.2 µM 0.318866791985718 0.404050691931558 no 1345 0.374913763501793 435 731709 SGTC_1697 st025554 27.742 µM 0.318223298563096 0.404259651276167 no 1346 0.375157780474729 392 1269519 SGTC_2058 5236698 133 µM 0.317922828451275 0.40435723123279 no 1347 0.375271737854187 381 766665 SGTC_2157 5649910 96.377 µM 0.317531055221007 0.40448447150844 no 1348 0.375420339533697 396 2858091 SGTC_1121 fusaric acid 630.51 nM 0.31718165811551 0.404597957371504 no 1349 0.375552883319155 377 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2180 6301957 200 µM 0.315963086272522 0.404993818128082 no 1350 0.376015263386381 419 845462 SGTC_510 ag-490 170 µM 0.311695411993082 0.406380963119896 no 1351 0.377636007539376 396 5328779 SGTC_3115 9123671 49.47 µM 0.311000060231435 0.406607088874356 no 1352 0.377900287921112 398 3286988 SGTC_2992 9074591 71.4286 µM 0.309798172816976 0.406998011502433 no 1353 0.378357220592275 390 17741321 SGTC_2910 7948405 25.97 µM 0.307224873101659 0.407835307112309 no 1354 0.37933610721594 427 2971328 SGTC_2293 7624732 200 µM 0.306885281055906 0.407945834494546 no 1355 0.379465346433145 396 894453 SGTC_36 0335-0881 14.2 µM 0.30495309029195 0.408574845840043 no 1356 0.380200940039331 397 23828853 SGTC_2433 5607874 27.82 µM 0.303577120670086 0.409022926962666 no 1357 0.380725042242291 424 2252428 SGTC_88 0180-0332 8.668 µM 0.30211159735936 0.409500301790662 no 1358 0.38128349593365 382 3101745 SGTC_986 1493-0483 84 µM 0.302003455479654 0.409535532902982 no 1359 0.381324714391318 428 40079 SGTC_3000 9075062 71.4286 µM 0.301046989360081 0.40984716796485 no 1360 0.381689331603405 391 17057871 SGTC_3320 9137005 35.139 µM 0.294692613987391 0.411918982835305 no 1361 0.384114352969169 427 4908713 SGTC_2115 tiliquinol 12.7705 µM 0.29458132881517 0.411955288919455 no 1362 0.384156863508087 431 71208 A bioactive hydroxyquinoline. SGTC_731 3966-0296 387 µM 0.293524465400906 0.412300121452264 no 1363 0.384560650959222 409 660956 SGTC_125 0133-0007 11.75 µM 0.29329977241017 0.412373442835444 no 1364 0.384646513797041 443 26541 SGTC_1223 0764-0573 147 µM 0.29308723681291 0.412442799856057 no 1365 0.384727736088947 403 1609797 SGTC_544 k015-0020 52.4 µM 0.292219129518131 0.412726118819394 no 1366 0.3850595432015 394 3008304 SGTC_1939 st074455 53.6 µM 0.288455575578793 0.413954931388327 no 1367 0.386499015727133 446 1644229 SGTC_3049 9092223 49.47 µM 0.286980858978473 0.414436661674532 no 1368 0.387063488196434 424 8623917 SGTC_1425 4048-4433 7.33 µM 0.286835430771972 0.414484174174628 no 1369 0.387119166239144 454 23734946 SGTC_3067 9117431 49.47 µM 0.286365163852815 0.414637822512193 no 1370 0.387299226583247 430 17150885 SGTC_1819 st053448 58.6 µM 0.28613369441325 0.414713454349159 no 1371 0.387387862747718 430 2857616 SGTC_383 2324-0395 7.37 µM 0.283573705812445 0.415550131989461 no 1372 0.388368544980448 426 3146421 SGTC_1662 st014054 52 µM 0.282589828734511 0.415871793314363 no 1373 0.388745639079029 431 2838777 SGTC_2605 digitonin 300 nM 0.282323412977543 0.415958902972927 no 1374 0.388847767257643 413 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1935 st074532 41.6 µM 0.281896492416266 0.416098501313891 no 1375 0.389011439581502 454 2829742 SGTC_496 calpeptin 138 µM 0.281236140072057 0.416314450132167 no 1376 0.389264643509173 404 73364 A calpain inhibitor. SGTC_1912 st060209 90.8 µM 0.281040264870784 0.416378510218782 no 1377 0.389339758477369 455 688787 SGTC_1246 0422-0085 105 µM 0.280610093390566 0.416519203622596 no 1378 0.389504736783864 455 264295 SGTC_562 3772-2733 112 µM 0.279502425862078 0.416881530462691 no 1379 0.389929638303319 448 2876874 YIL048W NEO1 SGTC_2782 7736369 71.43 µM 0.279140034762968 0.41700008681304 no 1380 0.3900686801996 412 2950836 YOL077C BRX1 SGTC_2442 5158906 48.48 µM 0.277098293858351 0.417668183688056 no 1381 0.390852315927257 435 1893835 SGTC_2757 clomiphene 4.22 µM 0.2767703969693 0.417775500057475 no 1382 0.390978206661621 454 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1165 k072-0275 30.3 µM 0.274875223335741 0.418395885372725 no 1383 0.391706051548306 409 6153523 YGL055W OLE1 SGTC_3283 9109332 35.8195 µM 0.274832582534346 0.418409846185621 no 1384 0.391722432197433 411 17027281 SGTC_1548 st061468 90.8 µM 0.274728780131959 0.418443832043989 no 1385 0.391762309143727 449 390799 SGTC_2916 7875993 68.79 µM 0.270326129035389 0.41988585779204 no 1386 0.393454682664568 434 1299250 SGTC_573 3702-0553 84.7 µM 0.269708546624284 0.420088224647906 no 1387 0.393692242442788 410 1222756 SGTC_3156 9099931 49.47 µM 0.269668787107233 0.420101253606859 no 1388 0.393707537729353 406 18111053 SGTC_1433 4060-0023 7.6 µM 0.26782764549055 0.420704680518877 no 1389 0.394415994920809 413 3840627 SGTC_2698 st077697 67.5 µM 0.26686109426256 0.421021538568284 no 1390 0.394788056443975 426 3154499 SGTC_1105 epirubicin 18.1 µM 0.266593078680788 0.421109409400266 no 1391 0.394891242622437 416 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1966 st070145 16.1 µM 0.264275221506858 0.421869499010454 no 1392 0.395783926056251 417 3748532 SGTC_2087 5276107 200 µM 0.263685373694675 0.422062973041663 no 1393 0.396011183437375 427 144405 SGTC_2874 9043904 71.43 µM 0.263206767724934 0.422219972829522 no 1394 0.3961956073887 424 4463428 SGTC_743 1275-0778 158 µM 0.262985731421759 0.422292484775644 no 1395 0.396280788405578 436 2849257 YMR203W TOM40 SGTC_1721 st082152 9.2685 µM 0.262029505763227 0.422606209185651 no 1396 0.396649347195034 407 5296051 SGTC_385 1494-0393 12.4 µM 0.261629733770814 0.422737383411587 no 1397 0.396803459016343 439 3090647 SGTC_2270 7924575 90.91 µM 0.260298029565004 0.42317440738643 no 1398 0.397316946206489 423 1262135 SGTC_394 menadione 8.33 µM 0.259757339024386 0.423351872251729 no 1399 0.397525480052422 447 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2592 piperlongumine 83.33 µM 0.25659732911921 0.424389357186926 no 1400 0.398744818520852 426 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_967 1306-0166 352 µM 0.256440957405216 0.42444071034561 no 1401 0.398805182731196 462 4437607 SGTC_95 0471-0001 561.058 µM 0.25598496452343 0.424590467734461 no 1402 0.398981223589455 383 4015405 SGTC_3253 9135987 49.47 µM 0.255982826046704 0.424591170079619 no 1403 0.398982049219374 424 4182430 SGTC_615 k087-0205 167 µM 0.25493460850086 0.424935467518907 no 1404 0.399386802732044 449 9642773 SGTC_2681 menadione 3.18 µM 0.253822354994682 0.425300860822191 no 1405 0.399816401052918 439 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1397 3532-0190 20.1 µM 0.249941851351028 0.426576169684927 no 1406 0.401316158709085 411 5322280 SGTC_2470 5664817 21.68 µM 0.249672957731972 0.426664568886258 no 1407 0.401420136302447 423 2859561 SGTC_1149 3909-7961 23.3 µM 0.249274452211197 0.426795584978687 no 1408 0.401574245934853 420 735261 SGTC_2312 7706453 155.7 µM 0.248910980633406 0.426915090054999 no 1409 0.40171482062844 432 976098 SGTC_10 0279-0212 42.575 µM 0.248180474829514 0.427155291842811 no 1410 0.401997386340558 425 39851 YBR002C RER2 SGTC_1106 tegaserod maleate 11.7 µM 0.247480011023228 0.427385640718152 no 1411 0.402268379676239 431 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2317 5986382 200 µM 0.24744723752246 0.427396418954056 no 1412 0.402281060141357 449 877883 SGTC_2250 alverine citrate 130 µM 0.246939758420697 0.427563320745311 no 1413 0.402477423080119 422 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_137 0438-0332 85.389 µM 0.245640026370641 0.427990840959875 no 1414 0.40298045088768 449 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_415 dibenzyl ketone 100 µM 0.245356397743107 0.428084146037825 no 1415 0.403090243419494 458 7593 SGTC_2617 dihydrotanshinone i 20.83 µM 0.245126018346585 0.428159936719513 no 1416 0.403179428818656 419 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1402 3909-7673 35.9 µM 0.244898361807896 0.42823483423332 no 1417 0.403267565081831 429 5328014 SGTC_2383 9036125 200 µM 0.244183572375597 0.42847001207589 no 1418 0.403544324694061 459 79580 SGTC_3232 9132874 49.47 µM 0.244178656029744 0.428471629725094 no 1419 0.403546228423454 437 3784940 SGTC_3092 9117248 49.47 µM 0.243566570895956 0.42867303645605 no 1420 0.403783260602065 432 17141857 SGTC_1446 4239-0190 62 µM 0.243384051955173 0.428733097946575 no 1421 0.40385394856512 447 1340085 SGTC_1789 tunicamycin 25 nM 0.24261806661386 0.428985178652168 no 1422 0.404150642094751 455 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1043 0916-0009 19.3 µM 0.2414551911223 0.429367928617697 no 1423 0.404601170729732 460 3101130 SGTC_292 k038-0015 474 µM 0.240351806814287 0.429731159006706 no 1424 0.405028767895269 417 46368540 SGTC_2165 5727197 32.143 µM 0.239545043277328 0.429996780507675 no 1425 0.405341486709069 440 1361712 SGTC_2622 2-methoxyxanthone 59.94 µM 0.238971542402311 0.430185621112282 no 1426 0.405563824687794 432 71034 A hepatoprotective. SGTC_2394 5221648 200 µM 0.237250402950265 0.430752448331448 no 1427 0.406231268196338 439 788586 SGTC_2197 6588183 93.1375 µM 0.237216595216215 0.430763583750918 no 1428 0.40624438128931 417 884136 SGTC_2620 irigenin 100 µM 0.234677404897521 0.431600086057892 no 1429 0.407229563152406 476 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_247 mechlorethamine 29.705 µM 0.234567016871615 0.431636458903807 no 1430 0.407272406026928 432 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_281 1672-3440 14.9 µM 0.233679232217616 0.431929004928126 no 1431 0.407617005854547 457 6833000 SGTC_3324 9138759 60.749 µM 0.233607790221171 0.431952548379442 no 1432 0.407644739677217 435 45595710 SGTC_856 0433-0016 11.3 µM 0.232721694616196 0.43224457804065 no 1433 0.407988760913339 444 3911780 SGTC_1398 3558-0053 112 µM 0.232334350778697 0.432372246208337 no 1434 0.408139167106376 443 4532369 SGTC_1114 scopoletin 1.73284 µM 0.232329313123477 0.432373906661345 no 1435 0.408141123324668 464 5280460 A coumarin with genotoxic properties. SGTC_2450 5739737 12.93 µM 0.230888724483188 0.432848785538422 no 1436 0.408700625325129 453 2262825 SGTC_1801 st050089 28.441 µM 0.229697128477976 0.433241659252503 no 1437 0.409163563198895 409 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2711 st079103 59.1 µM 0.227912491365757 0.433830184163006 no 1438 0.409857135781511 459 54693780 SGTC_808 0711-0032 135 µM 0.227211411448724 0.434061421515775 no 1439 0.410129677340186 458 4252555 SGTC_547 1120-0019 610 nM 0.226056392246197 0.434442430945766 no 1440 0.410578780313067 443 3676939 SGTC_648 0375-0473 33.3 µM 0.225951139593562 0.434477153967028 no 1441 0.410619711254475 451 1713139 SGTC_2967 9089538 49.85 µM 0.22523611033819 0.434713056648498 no 1442 0.410897799547264 437 728216 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.224682650708283 0.434895670191437 no 1443 0.411113081140401 422 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_972 1319-0219 195 µM 0.224201259849691 0.435054515998548 no 1444 0.411300351603363 468 23903702 SGTC_2171 5739187 198.077 µM 0.223594416460967 0.435254772639232 no 1445 0.411536454350696 424 2262761 SGTC_2161 5662504 8.5105 µM 0.22248017635005 0.435622511998898 no 1446 0.411970051786568 407 2859334 SGTC_2687 chenodiol 100 µM 0.222035234113606 0.43576937453167 no 1447 0.412143227486071 427 5702181 A cholesterol synthesis inhibitor. SGTC_314 1671-0008 2.74 µM 0.221128504078741 0.436068687226423 no 1448 0.412496188260951 452 3913060 SGTC_2611 pyromycin 23.93 µM 0.219750477812827 0.436523645442232 no 1449 0.413032744895351 416 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2219 9098279 200 µM 0.217015104990453 0.437426982664528 no 1450 0.414098286682363 445 902349 SGTC_2517 totarol 10 µM 0.211806473602601 0.439147994095927 no 1451 0.416129008950438 421 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1369 1866-0067 208 µM 0.211218069893665 0.439342484632571 no 1452 0.416358555542542 437 3531355 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.211079657617125 0.439388237455554 no 1453 0.416412556743554 426 16725076 SGTC_2808 7946468 45.46 µM 0.210529131742648 0.439570224357566 no 1454 0.416627358634343 456 2970879 SGTC_43 0570-0105 72.5 µM 0.206900787929252 0.440769960789822 no 1455 0.418043670576771 472 1114046 YDL195W SEC31 SGTC_952 1185-0122 232 µM 0.205095204069749 0.441367192663525 no 1456 0.418748871694761 468 678600 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.204586047429068 0.441535630257423 no 1457 0.418947778684393 431 688664 SGTC_646 4092-0839 27.3 µM 0.202849360019113 0.442110235070709 no 1458 0.419626388071468 468 877796 SGTC_1810 st050138 53 µM 0.202232537672729 0.442314347861867 no 1459 0.419867468615378 481 3444541 SGTC_893 0958-0369 48.9 µM 0.20149020651953 0.442560013095859 no 1460 0.420157643235383 466 6819948 SGTC_2736 butenafine 14.65 µM 0.200198378538329 0.442987580060434 no 1461 0.420662717622241 447 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3121 9125696 49.47 µM 0.198789397760981 0.443453997742576 no 1462 0.421213744920315 480 1235365 SGTC_261 5-fluorouridine 15.376 µM 0.197247576232603 0.443964479719989 no 1463 0.421816900708227 416 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1212 0520-0165 585 µM 0.196783645130052 0.444118100993085 no 1464 0.421998425082476 478 5403258 SGTC_2885 9057732 51.95 µM 0.195998907769066 0.444377969782523 no 1465 0.422305510445749 449 6471414 SGTC_3167 9103034 49.47 µM 0.195138079558274 0.444663063848558 no 1466 0.422642426189609 429 5127859 SGTC_1031 k035-0009 16 µM 0.194848825922229 0.444758866974422 no 1467 0.422755648606669 473 5180959 SGTC_1008 4106-0037 6 µM 0.194004045987039 0.445038683324041 no 1468 0.423086356927321 485 2905394 SGTC_1130 3454-2858 15.9 µM 0.193139865230539 0.44532495414242 no 1469 0.423424716224969 487 715628 YIL048W NEO1 SGTC_1281 0884-0031 11.8 µM 0.192173979366439 0.445644949802249 no 1470 0.423802963730785 443 1548255 SGTC_828 2074-0507 139 µM 0.191263101634525 0.445946753849197 no 1471 0.424159734013654 469 X828 SGTC_2203 7227154 166.4 µM 0.191003643610626 0.446032726649353 no 1472 0.42426136926255 442 896304 SGTC_2240 6690706 185.951 µM 0.190677254567619 0.446140881002756 no 1473 0.424389229973708 413 805876 SGTC_2626 ethyl orsellinate 100 µM 0.190606714357363 0.446164256183282 no 1474 0.424416864672589 457 75653 A natural product. SGTC_424 splitomicin 100 mM 0.190052911373057 0.446347778500272 no 1475 0.424633834377513 458 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2771 fluoxetine 41.05 µM 0.189624597800275 0.446489723321017 no 1476 0.424801655330838 484 3386 A selective serotonin reuptake inhibitor. SGTC_3290 9121031 71.43 µM 0.188982141404555 0.446702648774867 no 1477 0.425053406837221 452 17014854 SGTC_1791 st048313 56.1 µM 0.188779233391711 0.446769900551335 no 1478 0.425132924267446 464 1204976 SGTC_1570 verbenone 133 µM 0.187882489482406 0.447067135415114 no 1479 0.425484384828184 472 29025 A natural terpanoid with antifungal properties. SGTC_2925 9010536 32.5 µM 0.185767872606234 0.447768164063905 no 1480 0.426313399946599 443 2994177 SGTC_2748 diazoxide 86.69 µM 0.185487359989211 0.447861170700843 no 1481 0.426423396756237 474 3019 A potassium channel activatior. SGTC_1695 st026914 34.495 µM 0.185439744966244 0.44787695820113 no 1482 0.426442068501301 448 3289191 SGTC_726 3448-4391 34.2 µM 0.184940902814672 0.448042362022135 no 1483 0.426637694261042 467 1356692 SGTC_837 0091-0265 12.5 µM 0.184470636537196 0.448198299057336 no 1484 0.426822130244347 467 759367 SGTC_2892 9047358 58.44 µM 0.183340579490235 0.448573050818704 no 1485 0.427265398076019 455 6466771 SGTC_1458 k015-0034 6.33 µM 0.182671787814889 0.448794858480362 no 1486 0.427527776658396 465 3598957 SGTC_1157 4092-0394 27.6 µM 0.182627299060772 0.44880961393727 no 1487 0.42754523150722 456 3659885 SGTC_149 3970-0822 46.1 µM 0.181858671145446 0.449064553705363 no 1488 0.427846819609706 440 3114250 YBL034C STU1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.180884599030197 0.449387665743336 no 1489 0.428229078818198 450 23847180 SGTC_142 0335-0849 62.6745 µM 0.180386389464364 0.449552941143282 no 1490 0.428424619347575 448 3889043 YPR107C YTH1 SGTC_377 3970-0964 33.1 µM 0.179381734395148 0.449886250712221 no 1491 0.42881898630312 456 16481235 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.179134543588033 0.449968265443446 no 1492 0.428916029408095 482 140250 A respiratory chain inhibitor. SGTC_2045 5106652 78.05 µM 0.174537166233102 0.451494001890514 no 1493 0.430721662284816 485 673349 SGTC_1524 corynanthine 62.1 µM 0.174330579391738 0.45156257907952 no 1494 0.430802834153339 469 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3045 9092950 49.47 µM 0.174199729913047 0.451606015746977 no 1495 0.430854248895252 457 44120432 SGTC_1289 0976-0073 69.1 µM 0.174141819497514 0.451625239817964 no 1496 0.430877004033888 465 3391136 SGTC_1625 st003711 30.1 µM 0.174130168249768 0.451629107605919 no 1497 0.430881582266685 464 24207034 YER133W GLC7 SGTC_965 1291-5240 308 µM 0.173980762937049 0.451678705110106 no 1498 0.430940290304377 463 2834598 SGTC_1620 st003704 16.5 µM 0.171856929014623 0.452383827250402 no 1499 0.431775004185824 475 2834414 SGTC_1375 2910-0797 186 µM 0.170903239613469 0.452700505298778 no 1500 0.432149924649454 494 742508 SGTC_2800 7887935 81.82 µM 0.169255871382494 0.453247594152428 no 1501 0.432797692328042 458 2961002 SGTC_1384 3089-0840 101 µM 0.168080582173723 0.453637960479404 no 1502 0.433259942599228 449 1069836 SGTC_767 0929-0023 86 µM 0.167939173995554 0.453684931512514 no 1503 0.433315565688811 457 1204563 SGTC_2121 5257820 149.641 µM 0.166995145887894 0.453998522416034 no 1504 0.433686934157444 492 791256 SGTC_2070 5230947 200 µM 0.166824011832233 0.454055373464237 no 1505 0.43375426236379 477 2835538 SGTC_3336 9143619 71.43 µM 0.16527578889456 0.454569738613432 no 1506 0.434363457200423 486 45595730 SGTC_2905 7799065 20.05 µM 0.16156885680054 0.4558015983587 no 1507 0.435822691852573 477 1296806 SGTC_950 1165-0508 94.1 µM 0.15908012869066 0.456628872925616 no 1508 0.436802871926392 460 6148369 SGTC_323 4013-0906 34.3 µM 0.158552384801975 0.456804323803245 no 1509 0.437010772771639 479 2910086 SGTC_2448 5185112 27.17 µM 0.158219117468622 0.456915124397689 no 1510 0.437142069965612 442 5718189 SGTC_1674 st016616 23.6 µM 0.156779225079705 0.457393880372277 no 1511 0.437709423171544 448 625830 SGTC_1815 st051655 58.2 µM 0.156425955626412 0.457511349916033 no 1512 0.437848639684107 477 5984156 SGTC_1748 st037455 53.6035 µM 0.155042609682526 0.457971377249903 no 1513 0.438393862880871 477 580690 SGTC_1604 st002052 72.4 µM 0.153093090896622 0.45861977902881 no 1514 0.439162432158592 441 6254834 YHR062C RPP1 SGTC_3114 9122766 49.47 µM 0.151402849288618 0.459182035490843 no 1515 0.439828970983157 449 17176985 SGTC_603 3794-0023 45.9 µM 0.150854908620862 0.459364324754002 no 1516 0.44004508551261 462 3802260 SGTC_2110 5483698 200 µM 0.15038995663385 0.45951901199023 no 1517 0.440228482300586 467 2848765 YHR062C RPP1 SGTC_489 paxilline 115 µM 0.150341745228629 0.459535052038384 no 1518 0.440247499658529 473 105008 A toxic potassium channel blocker. SGTC_2614 arthonioic acid 13.39 µM 0.150181514178376 0.459588361759554 no 1519 0.440310705013286 456 6710684 SGTC_1097 itavastatin 7.23 µM 0.14953208287228 0.459804438433798 no 1520 0.440566897736375 492 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2320 7373003 200 µM 0.149108721598676 0.459945304217854 no 1521 0.440733921994062 459 5415828 SGTC_3313 9133968 57.047 µM 0.14893091385853 0.460004468018263 no 1522 0.440804073752108 494 1494643 SGTC_2816 7982706 58.44 µM 0.148743709967339 0.460066759253762 no 1523 0.440877934648282 466 2981853 SGTC_1224 0823-0416 294 µM 0.147948353929374 0.46033142123439 no 1524 0.441191763578529 477 3598164 SGTC_362 0310-0100 9.03 µM 0.145712842990019 0.46107540164983 no 1525 0.442074041173368 459 790235 SGTC_1984 st072354 53.1 µM 0.145052902276433 0.461295056786692 no 1526 0.442334551724118 482 5762938 SGTC_3004 9076122 71.4286 µM 0.142735026659105 0.46206663328453 no 1527 0.443249726330805 486 44782551 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.138844011246119 0.463362197508209 no 1528 0.444786707417782 475 2374 Ca(2+)-ATPase inhibitor. SGTC_273 hydroxyurea 18.1 mM 0.13838748848607 0.46351422844394 no 1529 0.444967092308852 491 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2131 toluylene red 5.2905 µM 0.138120666055515 0.463603087958451 no 1530 0.445072526581638 458 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_13 0199-0087 65 µM 0.136728473835287 0.464066757211602 no 1531 0.445622711013104 482 4589825 SGTC_211 3455-0679 143.504 µM 0.135259732321323 0.46455597408211 no 1532 0.446203260694158 456 748649 SGTC_2610 ononetin 44.17 µM 0.134648676062253 0.464759524042435 no 1533 0.446444827041336 474 259632 SGTC_2366 9070441 60.58 µM 0.133374828620963 0.465183887059801 no 1534 0.446948475693711 460 6837235 SGTC_74 000s-0487 160.283 µM 0.132221409869916 0.465568165253304 no 1535 0.447404583582771 444 677548 SGTC_448 monastrol 171 µM 0.130864954947877 0.4660201289515 no 1536 0.447941069057462 491 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3072 9116419 49.47 µM 0.130623390337756 0.466100621632694 no 1537 0.448036619224524 459 17170162 SGTC_2515 chrysin 20.77 µM 0.129944014971689 0.466327006358459 no 1538 0.448305360287006 474 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.129429717660993 0.46649839023081 no 1539 0.448508817074938 472 2724278 An inhibitor of dopamine biosynthesis. SGTC_2372 9071633 200 µM 0.129075081228129 0.466616572507818 no 1540 0.448649119672626 495 21321366 SGTC_3022 9087993 49.47 µM 0.128143202162166 0.466927134383292 no 1541 0.449017823735362 508 17173644 SGTC_1916 st067606 49.2 µM 0.124605295336072 0.468106373599974 no 1542 0.450418018001355 477 19590279 SGTC_429 1112-0049 25.5 µM 0.120552125660837 0.469457701349913 no 1543 0.452022895186216 438 2836170 SGTC_334 1502-1024 68.5 µM 0.120333395586049 0.469530636156368 no 1544 0.452109525229015 491 3296216 SGTC_1184 1269-1718 139 µM 0.120226718642823 0.469566207594707 no 1545 0.452151776433651 477 5403821 SGTC_2235 salicylic acid 500 µM 0.117298303149506 0.470542781941756 no 1546 0.453311834820112 489 338 A COX inhibitor and kinase inhibitor. SGTC_66 0109-0187 42.4 µM 0.116603788225528 0.470774416497497 no 1547 0.45358701781827 423 759417 SGTC_1716 st033144 30.6155 µM 0.116346763364109 0.47086014191748 no 1548 0.453688862715074 505 674617 SGTC_3110 9122132 49.47 µM 0.115165311462214 0.471254208501319 no 1549 0.454157046567462 464 918317 SGTC_472 calcifediol 10 µM 0.115048495838504 0.471293173225706 no 1550 0.454203341545647 475 5283731 A vitamin D metabolite. SGTC_3053 9095903 49.47 µM 0.114854478975966 0.47135788960736 no 1551 0.454280233374849 508 17174018 SGTC_559 1550-0661 158 µM 0.112667352674463 0.472087480691312 no 1552 0.455147142596322 493 5830875 SGTC_2673 kobusone 100 µM 0.112196658539027 0.472244509216331 no 1553 0.455333739271217 506 6710676 An epoxy ketone and protein crosslinker. SGTC_2954 9074818 52.69 µM 0.111996795302471 0.472311187005009 no 1554 0.455412973781712 503 16648742 SGTC_2801 7907800 81.82 µM 0.111870707190087 0.47235325255175 no 1555 0.455462961525492 510 6620925 SGTC_1452 4194-0072 190 µM 0.111642438065006 0.472429408536978 no 1556 0.455553460815451 492 1343545 SGTC_2575 plumbagin 510 nM 0.110853765853956 0.472692536000766 no 1557 0.455866154527917 503 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_978 1416-0512 87.4 µM 0.109631355024091 0.473100396703351 no 1558 0.456350871409951 492 6814003 SGTC_647 0140-0236 81 µM 0.109132410195916 0.473266879133371 no 1559 0.456548734392394 487 990837 SGTC_537 1334-0398 209 µM 0.109058451784907 0.47329155716171 no 1560 0.456578064468619 476 5846986 SGTC_315 k915-0449 187 µM 0.109056818069138 0.473292102291994 no 1561 0.45657871236255 499 20970215 YNL149C PGA2 SGTC_903 1134-0042 114 µM 0.107862842087871 0.473690515665467 no 1562 0.457052246411102 469 701009 SGTC_372 0155-0182 15.9 µM 0.107190387194473 0.473914916231018 no 1563 0.457318970699715 489 771486 SGTC_521 r062-0005 13.8 µM 0.103927780392071 0.475003775813255 no 1564 0.458613330456521 486 2832033 SGTC_2878 9043973 25.97 µM 0.103522984990057 0.475138885068064 no 1565 0.458773954056862 474 6465167 SGTC_1222 0366-0074 1.18 µM 0.100114353019937 0.476276701876258 no 1566 0.460126770260033 499 286520 SGTC_1907 st060210 83.7 µM 0.0997569505842627 0.476396015795938 no 1567 0.46026864297923 500 688793 SGTC_1505 k297-0037 20.6 µM 0.0990291597974324 0.476638985336768 no 1568 0.460557558861634 463 4089396 SGTC_15 0266-0086 27.098 µM 0.0989081549597164 0.476679383078822 no 1569 0.460605596968767 512 1712902 YIL048W NEO1 SGTC_404 fumagillin 50 µM 0.0986203929178635 0.476775454057143 no 1570 0.460719838873041 498 12015870 A methionine aminopeptidase binder. SGTC_2482 5981709 142.65 µM 0.0966724784197174 0.47742581149726 no 1571 0.461493248238159 497 877755 SGTC_3124 9127567 49.47 µM 0.0957095459328074 0.477747331654717 no 1572 0.461875629575283 492 17592030 SGTC_2142 5622915 118.518 µM 0.0953321718013075 0.47787333966362 no 1573 0.462025494806289 508 5322196 SGTC_665 3914-0008 307 µM 0.095273698099412 0.477892864662678 no 1574 0.462048716740098 482 1069549 SGTC_2767 sibutramine 71.45 µM 0.0934694331484972 0.478495354018919 no 1575 0.462765316087784 506 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1379 2144-0755 36.5 µM 0.0933042406272381 0.478550518424896 no 1576 0.462830931624248 511 5392327 SGTC_1851 st056236 18.9 µM 0.0932606948876154 0.478565060161733 no 1577 0.462848228441809 502 5393171 SGTC_2285 7945142 200 µM 0.0932102837952237 0.478581894561547 no 1578 0.462868252336129 513 2970608 SGTC_1278 0874-0585 172 µM 0.0930430475364327 0.478637742108127 no 1579 0.462934681270067 493 766306 SGTC_1409 3909-8004 61.9 µM 0.0920399157516135 0.478972740722422 no 1580 0.46333316299291 502 2119279 SGTC_3057 9095946 49.47 µM 0.0913122997535051 0.479215739391959 no 1581 0.463622222514644 513 24540043 SGTC_422 cantharidin 155 µM 0.0908728105467616 0.479362517390234 no 1582 0.463796827411788 522 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3128 9127691 49.47 µM 0.0900823040458982 0.479626533092984 no 1583 0.464110905683287 510 41316314 SGTC_2978 9011784 42.97 µM 0.0899780633664023 0.479661348373465 no 1584 0.464152323502364 475 2994934 SGTC_300 r073-0011 5.04 µM 0.089570345826943 0.479797523191767 no 1585 0.464314325130503 503 2735780 SGTC_3 0833-0587 95.581 µM 0.0868104516083398 0.480719369836689 no 1586 0.465411089903839 493 5382644 SGTC_1702 st027038 51 µM 0.0863208221783217 0.480882924424209 no 1587 0.46560569327475 488 5521182 SGTC_1166 k206-0078 225 µM 0.0862484204772397 0.480907109580737 no 1588 0.465634470052776 498 5404595 SGTC_327 1273-0057 3.96 µM 0.085754422894569 0.481072127033975 no 1589 0.465830819105824 526 3108138 SGTC_3234 9132280 49.47 µM 0.0847242851870932 0.481416249849471 no 1590 0.466240294296909 471 17612295 SGTC_470 aa-861 153 µM 0.0846337117154121 0.481446507050972 no 1591 0.466276298567652 504 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_311 1315-0136 58 µM 0.0838047538831841 0.481723435730501 no 1592 0.466605834133446 501 6759207 SGTC_2145 5634607 200 µM 0.0835587368027263 0.481805623984688 no 1593 0.466703637706759 508 308662 SGTC_1963 st076565 50.3 µM 0.0832711304385325 0.481901707175592 no 1594 0.466817977561112 493 4914280 SGTC_501 nsc-95397 161 µM 0.0831710075385868 0.481935156361486 no 1595 0.466857782739897 509 262093 SGTC_2727 riluzole 51.77 µM 0.0813504769038461 0.482543383497442 no 1596 0.467581616106959 507 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1151 3909-8316 15.3 µM 0.0799735045274375 0.48300344784328 no 1597 0.468129164390958 511 800431 SGTC_218 alverine citrate 93.75 µM 0.0798323588677164 0.483050607729634 no 1598 0.468185293897162 510 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3327 9140648 26.9345 µM 0.0796746188757296 0.483103312429951 no 1599 0.468248023232938 517 8029710 SGTC_216 k038-0035 28.382 µM 0.0796175173953292 0.483122391471754 no 1600 0.468270731289164 493 4444231 YPR107C YTH1 SGTC_2623 humulene 100 µM 0.0793661681658792 0.483206374034472 no 1601 0.468370688810804 493 6187145 An anti-inflammatory. SGTC_2897 9048598 12.99 µM 0.0789573663110193 0.483342967359547 no 1602 0.468533266950097 510 6467404 SGTC_2966 9084041 48.03 µM 0.0784884384191682 0.483499653056995 no 1603 0.468719763328085 471 17741380 SGTC_392 N-ethylmaleimide 8.33 µM 0.0781719675406134 0.483605398817109 no 1604 0.468845630212899 502 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1624 st003710 6.25 µM 0.077875460388163 0.483704474932886 no 1605 0.468963559944746 521 24207033 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0774363557441988 0.483851201005789 no 1606 0.469138209948438 468 641818 YHR062C RPP1 SGTC_2817 7995342 71.43 µM 0.0771599627726845 0.48394355837171 no 1607 0.469248145865494 498 18879975 SGTC_2013 4024628 200 µM 0.0769759683284327 0.484005041028883 no 1608 0.469321331363934 500 5230760 SGTC_2455 5377712 9.75 µM 0.0757882164951529 0.484401943289457 no 1609 0.469793795518117 517 2243908 SGTC_1830 st055982 50.3 µM 0.075388313496781 0.484535579419174 no 1610 0.469952878613932 507 455313 An antimicrobial agent. SGTC_1245 0418-0076 17.2 µM 0.0742585403297718 0.484913126593505 no 1611 0.470402332965834 510 6790114 SGTC_2927 9011802 47.9 µM 0.0741500128103581 0.48494939499675 no 1612 0.470445510145402 499 43912568 SGTC_2054 5233173 129 µM 0.0738528040840749 0.485048718698867 no 1613 0.470563755061424 509 6889 SGTC_1018 4259-0013 28.1 µM 0.0735336450655021 0.485155378966314 no 1614 0.470690735822362 496 6801262 SGTC_1026 k007-1105 30.6 µM 0.0708198847154267 0.486062337055479 no 1615 0.471770552922409 508 7066794 SGTC_1865 st057639 52.2 µM 0.0692819605248777 0.486576354611333 no 1616 0.47238259232317 520 688818 SGTC_1523 st012844 44.7 µM 0.0685457971128749 0.4868224090914 no 1617 0.472675582477135 466 4274103 SGTC_126 0417-1624 672.48 µM 0.0676805664094656 0.487111609292327 no 1618 0.473019959796023 515 41912 YDL195W SEC31 SGTC_306 1672-3436 11.6 µM 0.0676330780473704 0.487127482301422 no 1619 0.473038861600952 522 6797378 SGTC_2153 5569715 200 µM 0.0675199381435131 0.487165299453741 no 1620 0.473083894950402 519 2054701 SGTC_2078 5212016 200 µM 0.0669821036431188 0.487345072870932 no 1621 0.473297975211731 527 1899708 SGTC_826 1683-5028 118 µM 0.0665841341483892 0.487478097486059 no 1622 0.473456388414018 506 722377 SGTC_2937 9044753 11.33 µM 0.0639540411540187 0.48835726228682 no 1623 0.474503410846914 517 6465530 YGL099W LSG1 SGTC_2263 7948595 193.29 µM 0.0638359650368065 0.488396733111763 no 1624 0.474550420344525 511 2971371 SGTC_2094 5332512 191.667 µM 0.0627110848002257 0.48877276696443 no 1625 0.474998285187632 517 755774 SGTC_2163 5671233 125 µM 0.0624746848122858 0.488851793900387 no 1626 0.475092410571499 517 701023 SGTC_2561 acetosyringone 100 µM 0.0613459552732996 0.489229126621428 no 1627 0.475541846339644 524 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0608472816659925 0.48939583560791 no 1628 0.475740417364952 526 1241132 A phosphatase inhibitor. SGTC_1903 st060211 78.3 µM 0.0599656100924827 0.489690587172511 no 1629 0.476091512275101 512 688960 SGTC_2479 5617353 43.85 µM 0.0597401058321034 0.489765976397264 no 1630 0.476181314462554 512 2731746 SGTC_2686 alizarin 95.37 µM 0.0595501851505653 0.489829469818221 no 1631 0.476256947199135 503 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_834 0312-0008 75.7 µM 0.0593370322026083 0.489900730452003 no 1632 0.476341832816072 525 6385573 YIL048W NEO1 SGTC_847 0342-0274 5.54 µM 0.0584314895755434 0.490203472226573 no 1633 0.476702466279799 516 18097 SGTC_821 1114-0266 29.2 µM 0.0579462795574348 0.490365690382285 no 1634 0.476895709636103 519 3123235 SGTC_2921 7974240 10.71 µM 0.0573107995826002 0.490578150045378 no 1635 0.477148808835659 517 2979074 YDR527W RBA50 SGTC_1630 st005209 31.3 µM 0.0561090279583216 0.490979944936566 no 1636 0.477627475999812 523 3367314 SGTC_1252 0493-0875 34.8 µM 0.0552479450462619 0.491267841156318 no 1637 0.477970466306457 517 3960963 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0541384503420989 0.491638798567654 no 1638 0.478412429104807 514 107982 A Capsaicinoid. SGTC_1473 k844-0725 134 µM 0.0541309168034814 0.49164131741682 no 1639 0.47841543015128 521 54682906 SGTC_2570 licareol 100 µM 0.053422087954845 0.491878316810245 no 1640 0.478697803348085 515 443158 SGTC_2337 9009472 200 µM 0.0520124329962351 0.492349648292249 no 1641 0.479259393362904 521 5742383 SGTC_2478 5763493 32.33 µM 0.0519821141216798 0.492359785814712 no 1642 0.47927147250353 522 1365576 YLR208W SEC13 SGTC_1675 st018485 24.5 µM 0.0519720192368061 0.492363161175997 no 1643 0.479275494343518 528 3323024 SGTC_1650 st011916 45.8 µM 0.0514588872715791 0.492534734503412 no 1644 0.479479930813309 525 242528 SGTC_1632 st005650 90 µM 0.0505678465190684 0.492832670534347 no 1645 0.479834942396046 520 2759605 SGTC_1797 st048695 56.8 µM 0.0500674965445745 0.492999973608348 no 1646 0.48003430061962 528 592262 YIL048W NEO1 SGTC_1985 st071382 65.5 µM 0.0488174338995834 0.493417965002735 no 1647 0.480532394248023 511 6123237 SGTC_2569 tetrandrine 100 µM 0.0482101051104436 0.49362104402821 no 1648 0.480774398419971 519 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_729 4092-0585 94.1 µM 0.0455117071787946 0.494523355477314 no 1649 0.481849721794721 516 2169061 SGTC_3271 9137798 49.47 µM 0.0447428431585139 0.494780459585248 no 1650 0.482156141985936 532 6498326 SGTC_1410 3909-8106 77.9 µM 0.0445569495526373 0.494842621764523 no 1651 0.482230228917706 532 1039210 SGTC_1807 st050092 58.9 µM 0.0441692600092516 0.494972264208983 no 1652 0.48238474254445 515 5008496 SGTC_2951 9072950 58.06 µM 0.0425392527926583 0.495517340324447 no 1653 0.483034410426536 529 16488155 SGTC_3344 9148862 3.898 µM 0.0421068286771962 0.495661944846672 no 1654 0.483206768251673 518 4905352 SGTC_1969 st069479 40.1 µM 0.0419960213615159 0.495698999391898 no 1655 0.483250934907143 530 3895485 SGTC_2906 7926292 26.41 µM 0.0416321183711258 0.495820690712261 no 1656 0.483395984336329 524 2966319 SGTC_1764 st044502 93.5 µM 0.0410349316425448 0.496020394337135 no 1657 0.48363402394064 514 8407 SGTC_2984 9022109 38.96 µM 0.0406440487707671 0.496151108981338 no 1658 0.483789833654989 526 6459207 SGTC_1847 st056231 15 µM 0.0391392200830795 0.496654340562876 no 1659 0.484389695903635 528 5393180 SGTC_1904 st060225 78 µM 0.0388780161289101 0.496741690657829 no 1660 0.484493821951459 516 66595 SGTC_1038 k292-0204 154 µM 0.0377291579113023 0.497125886005928 no 1661 0.484951813945357 529 4454212 SGTC_2265 7929201 200 µM 0.0369856364011341 0.497374532147849 no 1662 0.485248229198271 528 1265108 SGTC_2938 9059746 27.26 µM 0.0358567918855515 0.497752038723963 no 1663 0.485698274387086 526 6471769 SGTC_538 2922-0838 53.3 µM 0.0355542566026139 0.497853212498699 no 1664 0.485818891591293 505 777039 SGTC_718 1130-0073 349 µM 0.0348718492046072 0.498081423509484 no 1665 0.486090964017901 532 6740020 SGTC_3186 9110464 49.47 µM 0.0343626634250535 0.498251706076297 no 1666 0.486293978073906 519 17018021 SGTC_1634 st006576 41 µM 0.0340309725419395 0.498362630743594 no 1667 0.486426226241005 535 3915356 SGTC_179 1273-0063 6.77 µM 0.0339421406491536 0.498392338088295 no 1668 0.486461644577353 535 3108139 SGTC_730 1436-0052 41.2 µM 0.0336638959150912 0.49848538932276 no 1669 0.48657258476503 513 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_773 4358-1457 44.6 µM 0.0334900200768658 0.498543537316737 no 1670 0.486641912097097 534 1186886 SGTC_1472 k841-0093 193 µM 0.0320546514084764 0.499023557975266 no 1671 0.487214233871008 524 X1472 SGTC_1370 2001-0092 44.6 µM 0.0317737432149054 0.499117500394199 no 1672 0.48732624296991 532 790957 SGTC_2159 5658611 73.75 µM 0.0314516026579741 0.499225231961594 no 1673 0.487454694257099 523 793844 SGTC_568 1193-0097 7.48 µM 0.0310242889956691 0.499368136036469 no 1674 0.487625084588175 522 3646150 SGTC_2406 ethylparaben 405.7 µM 0.0310189554463632 0.499369919705543 no 1675 0.48762721134292 493 8434 A possible steroid mimic. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0308214255973344 0.499435978517135 no 1676 0.487705976690082 532 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_285 1486-1325 46 µM 0.0307922286144926 0.499445742703488 no 1677 0.487717619075022 528 22310230 SGTC_1123 mangostin 811.285 nM 0.0291946400370483 0.499980015809274 no 1678 0.48835467802202 532 5281650 An antioxidant. SGTC_91 0417-1751 58.384 µM 0.0290751262384084 0.499980015809274 no 1679 0.488402336897653 539 6795624 SGTC_1432 4049-0298 68.4 µM 0.0283354694755214 0.499732656244098 no 1680 0.488697295699436 539 741646 SGTC_228 caffeine 993.056 µM 0.0275092367665491 0.499456343661362 no 1681 0.489026786381098 521 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_14 0354-0009 295 µM 0.0259583748289436 0.498937698012844 no 1682 0.489645269663741 539 1713507 SGTC_690 glyoxal 20.3 µM 0.025263340961624 0.498705262449308 no 1683 0.489922457133386 537 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_297 0986-0032 24 µM 0.0243799950170209 0.498409851572079 no 1684 0.490274752623437 533 2847425 SGTC_3227 9130768 49.47 µM 0.024354341738043 0.498401272547206 no 1685 0.490284983763186 535 17720899 SGTC_1728 st035614 33.7865 µM 0.024126600604254 0.49832511089903 no 1686 0.49037581264078 517 15945546 SGTC_1138 3761-0006 1.03 µM 0.0231971465255252 0.498014281658468 no 1687 0.490746507369539 535 12061087 SGTC_1285 0929-0069 65.5 µM 0.023110975558467 0.49798546430988 no 1688 0.490780875397864 528 1206237 SGTC_1457 k015-0032 57.3 µM 0.0229142160952993 0.497919663927042 no 1689 0.490859350284565 536 4302660 SGTC_3300 9124615 50.48 µM 0.0221752816039761 0.497672549662184 no 1690 0.491154067582033 524 24824903 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0212611964691016 0.49736686281434 no 1691 0.491518648784213 539 165521 SGTC_3185 9108267 49.47 µM 0.0201931680139029 0.497009696465701 no 1692 0.491944638955477 534 4910486 SGTC_58 0957-0393 9 µM 0.0198048337696354 0.496879831662135 no 1693 0.492099530925074 539 6997992 SGTC_2875 9039966 71.43 µM 0.0195946600542091 0.496809546552178 no 1694 0.492183361838103 528 6463691 SGTC_2746 daunorubicin 9.88 µM 0.0194523461304707 0.496761954787587 no 1695 0.492240126059964 536 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3354 9151612 71.43 µM 0.0188648308417776 0.496565481961238 no 1696 0.492474467733956 538 27261949 SGTC_744 1594-0068 283 µM 0.0156683175063252 0.495496541764926 no 1697 0.493749501430599 538 668392 SGTC_2749 bexarotene 57.39 µM 0.0154601909368842 0.495426943576566 no 1698 0.493832521862381 539 82146 An retinoic acid receptor inhibitor. SGTC_3267 9137951 49.47 µM 0.0153724351485624 0.495397597802768 no 1699 0.493867527196703 540 16643986 SGTC_865 0488-0499 301 µM 0.0148695074767779 0.495229417909497 no 1700 0.494068143370717 539 9634651 SGTC_1910 st062352 60.4 µM 0.014819228800336 0.495212604678263 no 1701 0.494088199450697 542 2245730 SGTC_2314 7727897 200 µM 0.0141806558469414 0.494999066101374 no 1702 0.494342926417233 541 900724 SGTC_798 1287-0182 476 µM 0.013061407706435 0.494624793400405 no 1703 0.494789400379802 535 1649755 SGTC_2710 st078562 53.7235 µM 0.0128930961875737 0.494568511012738 no 1704 0.494856541307066 537 17250908 SGTC_75 0159-0059 199.013 µM 0.0128259204293468 0.494546047862138 no 1705 0.494883338341472 545 5377270 SGTC_2242 6630449 61.2675 µM 0.0122886787532266 0.494366398256397 no 1706 0.495097649860688 528 691249 YDR170C SEC7 SGTC_802 4112-3352 742 µM 0.0112868143278555 0.494031385351959 no 1707 0.495497308155067 537 704594 SGTC_2313 7726885 200 µM 0.0103729279710016 0.49372579505163 no 1708 0.495861874669692 545 726423 SGTC_1359 1582-0056 520 nM 0.00911778374007443 0.493306099121094 no 1709 0.496362580961451 540 3661189 SGTC_1596 piperlongumine 63 µM 0.00842269748697923 0.493073678893529 no 1710 0.496639869586428 537 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2098 5376439 882.5 nM 0.0083924041761717 0.493063549587431 no 1711 0.496651954441794 540 2844116 SGTC_3284 9108171 64.8615 µM 0.00761237817996018 0.49280273046114 no 1712 0.496963129819882 541 8687505 SGTC_1895 st058434 18.3 µM 0.00713317663291872 0.49264250023186 no 1713 0.497154298380175 541 5393175 SGTC_695 3505-6186 243 µM 0.00547835067475543 0.492089186720556 no 1714 0.497814465221144 545 1819379 SGTC_1746 st038117 42 µM 0.00503479042901317 0.491940878876884 no 1715 0.497991417710874 546 2898218 SGTC_790 1575-0012 79.1 µM 0.00489501210581227 0.491894143129175 no 1716 0.498047180506549 541 378741 YLR208W SEC13 SGTC_152 4469-0003 551.229 µM 0.00469214674689579 0.491826314038624 no 1717 0.498128111145477 543 697280 SGTC_1751 st044839 27.194 µM 0.00296993111318557 0.491250491978629 no 1718 0.498815170650867 547 5291326 SGTC_3237 9133362 49.47 µM 0.0024189167317055 0.491066264348662 no 1719 0.499034992784021 543 43845137 SGTC_308 4092-1169 104 µM 0.00232434174444832 0.491034644083642 no 1720 0.499072722638984 546 2268590 YDL196W YDL196W SGTC_2204 7233102 200 µM 0.00134259389002276 0.490706409208602 no 1721 0.499464382692775 545 2172480 SGTC_2185 6113692 200 µM 0.00109619779677103 0.490624030796319 no 1722 0.499562680438769 548 874150 SGTC_1463 k081-0032 34.1 µM 0.00103373358194312 0.490603146994342 no 1723 0.499587600040941 541 977755 SGTC_781 4335-2806 94.4 µM 0.000360995185455722 0.490378230491818 no 1724 0.499855983760628 548 845254 SGTC_939 1165-0479 45.3 µM 6.79431361992927e-05 0.490280255407319 no 1725 0.499972894610328 548 1377347 SGTC_1937 st074714 47.2 µM -5.75238745935971e-05 0.490238308631739 no 1726 0.499977051294305 548 17250970 SGTC_775 4577-0580 57.3 µM -0.000827172799772647 0.489980998029128 no 1727 0.499670005834604 554 2006902 SGTC_2458 5808907 16.39 µM -0.00357973493893737 0.489060790699799 no 1728 0.498571895430303 552 2731747 SGTC_656 4090-1979 187 µM -0.00378544857094553 0.48899202098178 no 1729 0.498489828121464 550 22330961 SGTC_3265 9137266 49.47 µM -0.00434053893006701 0.488806456855643 no 1730 0.498268380938434 552 17224265 SGTC_2638 epoxomicin 18 µM -0.00509907337988101 0.488552886241684 no 1731 0.49796577285307 554 9915668 A protesome inhibitor. SGTC_1248 0469-0687 58.6 µM -0.0053591173337611 0.488465957162711 no 1732 0.497862031743726 553 4017482 SGTC_3304 9125678 46.087 µM -0.00651571072352141 0.488079330765649 no 1733 0.497400625898051 553 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1120 ficusin 1.78878 µM -0.00699323073278498 0.487919708475438 no 1734 0.497210127324023 558 6199 A DNA cross-linker. SGTC_1506 4226-2149 212 µM -0.00781278787660016 0.487645756756112 no 1735 0.496883180296515 563 991114 SGTC_1054 3429-0080 167 µM -0.00966925953374244 0.487025219465602 no 1736 0.496142583659829 555 1162877 SGTC_1923 st058458 19.1 µM -0.0101598985115623 0.48686122549765 no 1737 0.495946856649236 556 3534982 SGTC_454 lyso-paf C-16 6.67 µM -0.0109240943717629 0.486605800753901 no 1738 0.495642003557707 557 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2309 7664088 163.95 µM -0.0113320341797512 0.486469453238265 no 1739 0.49547926919789 553 704922 SGTC_1056 3448-1962 115 µM -0.0115648054337057 0.486391653786336 no 1740 0.495386412988595 557 715507 SGTC_2753 fluvastatin 17.09 µM -0.0132699123551608 0.48582176957036 no 1741 0.494706226268703 558 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3025 9087895 49.47 µM -0.0166672201359671 0.484686402091735 no 1742 0.493351049034678 557 17173641 SGTC_2205 7238770 200 µM -0.016691279187522 0.48467836207905 no 1743 0.493341452196787 558 279867 SGTC_3007 9078383 71.4286 µM -0.0198842179322474 0.483611407812935 no 1744 0.492067867461454 563 6496995 SGTC_342 k048-0088 23.3 µM -0.0218250126561679 0.482962927572767 no 1745 0.491293770861374 555 6820570 SGTC_1055 3448-0672 86 µM -0.0218355700361029 0.482959400143507 no 1746 0.491289560079616 560 748378 SGTC_1780 st038448 24.544 µM -0.0229999481661619 0.48257036664876 no 1747 0.490825157148273 570 728868 YDL195W SEC31 SGTC_2326 6164455 177.58 µM -0.0233270773176575 0.482461071622177 no 1748 0.490694686505769 564 2888790 SGTC_1881 5652484 16 µM -0.0236088965361208 0.482366915863819 no 1749 0.490582287860303 563 2255129 SGTC_1987 st072290 61.9 µM -0.0239734222311256 0.482245129343654 no 1750 0.490436904299848 559 54697379 SGTC_1231 0242-0792 125 µM -0.0247530596574166 0.481984661294303 no 1751 0.490125966270041 557 3707635 SGTC_214 4373-3496 70 µM -0.0251345550715678 0.48185721078481 no 1752 0.489973818960378 561 3779166 SGTC_1317 1273-0028 910 nM -0.0259180150978206 0.481595477216547 no 1753 0.489661365451457 564 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2272 7805186 180 µM -0.0261370571279307 0.481522302399329 no 1754 0.489574009918392 559 2956062 YPR165W RHO1 SGTC_1618 st003135 44.5 µM -0.0286473670756993 0.480683734564391 no 1755 0.488572917053182 558 1270615 SGTC_1465 k213-0056 144 µM -0.029274799595916 0.48047415423806 no 1756 0.488322712647641 557 24048857 YMR208W ERG12 SGTC_1462 k081-0014 26.5 µM -0.0309792670507702 0.479904840991075 no 1757 0.487643037116287 562 3270634 SGTC_1496 4469-0713 57.4 µM -0.0309932872369856 0.47990015824356 no 1758 0.487637446555757 566 746691 SGTC_2844 9010103 25.97 µM -0.0313602330807108 0.479777599180876 no 1759 0.487491127472551 567 2480525 SGTC_565 1418-0001 44.5 µM -0.0342756376418552 0.478803929689774 no 1760 0.48632867589866 579 2862145 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.034381616399339 0.478768537881437 no 1761 0.486286421396339 559 6708760 SGTC_366 0181-0206 4.31 µM -0.0345703676474318 0.478705504456658 no 1762 0.486211165280885 572 274874 SGTC_1265 0819-1001 68.8 µM -0.0354666167754363 0.478406209614832 no 1763 0.485853832786575 574 3106768 SGTC_1672 st016598 6.51 µM -0.0358428631017295 0.478280568944772 no 1764 0.485703827598199 599 4665860 YNL267W PIK1 SGTC_3174 9107204 49.47 µM -0.036013744690978 0.478223506834187 no 1765 0.485635699692797 576 3938802 SGTC_386 1509-0011 3.07 µM -0.036225319959418 0.478152856592091 no 1766 0.485551348414045 573 3107280 SGTC_1213 1315-0166 115 µM -0.0368229548074946 0.477953295174374 no 1767 0.485313085584272 572 768401 SGTC_971 1315-0384 26.7 µM -0.0377418843210961 0.477646458279546 no 1768 0.484946740455946 578 6769120 SGTC_629 3448-6466 76.7 µM -0.0385478889325517 0.477377338689408 no 1769 0.484625424994182 566 573744 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0398249432547825 0.47695095989816 no 1770 0.484116345080578 570 165506 SGTC_1930 st074634 34.3 µM -0.0398661193150602 0.476937212604014 no 1771 0.484099931244215 578 684253 YOR116C RPO31 SGTC_1362 1611-0397 101 µM -0.0402104806263399 0.476822243083045 no 1772 0.483962661028766 563 27816 SGTC_3019 9081971 49.47 µM -0.0416121948797554 0.476354282483745 no 1773 0.483403925777537 568 16451803 SGTC_1608 st001473 40.5 µM -0.0429936578477457 0.475893114654265 no 1774 0.482853294742494 567 7292267 SGTC_1638 st008370 60.6 µM -0.0443009049669567 0.475456751706076 no 1775 0.482332275162555 565 24207134 SGTC_2948 9070189 9.45 µM -0.0443014275792319 0.475456577262407 no 1776 0.482332066874915 569 6473636 YDL196W YDL196W SGTC_460 trequinsin 123 µM -0.0451199335670986 0.475183372506495 no 1777 0.48200585645634 559 5537 A vasodilator. SGTC_2965 9082772 38.63 µM -0.0461831222812213 0.474828513846758 no 1778 0.481582147294366 567 16459634 SGTC_3168 9103419 49.47 µM -0.0462311931149556 0.474812469797365 no 1779 0.481562990268354 563 16649256 SGTC_614 0462-0418 107 µM -0.0472800120408379 0.474462427777611 no 1780 0.481145029172767 562 5188303 SGTC_233 rapamycin 362 pM -0.0476712969584203 0.474331841954891 no 1781 0.480989104897314 566 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_686 1319-0111 510 µM -0.0479011712928932 0.4742551259229 no 1782 0.480897502953671 569 4562600 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0482217938264523 0.474148126061626 no 1783 0.480769740714165 578 442882 SGTC_3150 9097574 49.47 µM -0.0482241821863418 0.474147329012418 no 1784 0.480768789003649 580 17217476 SGTC_1296 1068-0102 11.9 µM -0.0487535539521524 0.473970668352476 no 1785 0.480557848351195 575 767053 SGTC_2834 9001755 58.44 µM -0.0495165328095976 0.473716057915301 no 1786 0.480253831042134 591 2989575 SGTC_1479 0549-0158 134 µM -0.0499277208599945 0.473578846541316 no 1787 0.480089993397093 584 5440202 SGTC_2016 5121758 140 µM -0.0508847662049742 0.473259497513313 no 1788 0.479708672295396 579 2795203 SGTC_363 0455-0021 3.06 µM -0.0514942253899792 0.473056140755056 no 1789 0.479465851609922 584 4597466 SGTC_1388 3346-4487 254 µM -0.0527801554533351 0.472627090713426 no 1790 0.478953536556247 577 3345614 SGTC_3256 9138902 49.47 µM -0.0543423575337626 0.472105905398711 no 1791 0.478331201479548 567 17228773 SGTC_2364 9055074 200 µM -0.0555173501474184 0.471713933184221 no 1792 0.477863153923927 583 6470630 SGTC_2133 5320837 200 µM -0.0556099520601439 0.471683042765219 no 1793 0.477826268088854 584 2841355 SGTC_3118 9124250 49.47 µM -0.0558642484639203 0.471598214698037 no 1794 0.47772497596246 569 1504786 SGTC_1709 st033179 39.1045 µM -0.0559148499879597 0.471581335220535 no 1795 0.477704820379076 581 573381 SGTC_558 k064-0027 21.3 µM -0.0564810127002376 0.471392480152247 no 1796 0.477479310523336 578 5088526 SGTC_1750 st081859 2.357 µM -0.0567487154554092 0.471303184700028 no 1797 0.477372683595637 587 5291695 SGTC_1850 st056238 17 µM -0.0568049698447738 0.471284420559668 no 1798 0.477350277484665 569 5393177 SGTC_811 0416-0114 265 µM -0.0583065647304508 0.470783574230652 no 1799 0.476752219257331 567 6612453 SGTC_3330 9141424 71.43 µM -0.0613054275563542 0.469783463875449 no 1800 0.475557984184981 572 27261020 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0619946839721468 0.469553625959205 no 1801 0.475283532717871 574 676296 Flavone; oxidizing agent. SGTC_2768 sulfasalazine 50.2 µM -0.0620120324341911 0.469547841110076 no 1802 0.475276624973754 584 5384001 An antioxidant and salicylic acid derivative. SGTC_1787 fluconazole 80 µM -0.0622688621472087 0.469462201928861 no 1803 0.475174362373574 578 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_981 1488-1094 54.9 µM -0.0628115009849858 0.469281265109524 no 1804 0.47495830374655 570 3449522 SGTC_2279 7948423 32.93 µM -0.0638153136618131 0.468946571808164 no 1805 0.474558642287177 574 1247112 SGTC_196 k015-0023 18.111 µM -0.0642789522961882 0.468791991848679 no 1806 0.474374056212551 583 5211998 SGTC_1220 1838-0075 193 µM -0.0647064707990358 0.468649458730691 no 1807 0.474203855334809 585 5529645 SGTC_1109 tnp00067 928.257 nM -0.0648047175369812 0.468616704191813 no 1808 0.474164742648534 572 676295 SGTC_3020 9089140 49.47 µM -0.0653361752683469 0.468439524868271 no 1809 0.473953170082568 575 17217859 SGTC_2508 celastrol 40.54 µM -0.0655467540931738 0.468369323056126 no 1810 0.473869340981101 572 122724 Celastrol is a natural product and antioxidant. SGTC_1366 1683-0113 21.9 µM -0.0657746725831544 0.46829334173362 no 1811 0.473778610454705 587 708623 SGTC_556 4058-0063 51.5 µM -0.066892857737158 0.467920588469008 no 1812 0.473333499502209 589 6615692 SGTC_2596 sinensetin 100 µM -0.0688912686023703 0.467254477310061 no 1813 0.472538084326963 582 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2898 9056270 58.44 µM -0.0689888081321181 0.467221967724317 no 1814 0.472499264045387 582 19154699 SGTC_1210 3013-0140 750 nM -0.06914909358194 0.467168545616786 no 1815 0.472435471745425 582 905973 SGTC_857 0438-0306 1.35 µM -0.0696027159353098 0.467017359417936 no 1816 0.472254937590957 574 4686136 SGTC_3353 9151644 39.2805 µM -0.0696951905086179 0.466986539475799 no 1817 0.472218134946543 592 4909158 SGTC_1798 st045719 60.953 µM -0.0700439845207998 0.466870295128512 no 1818 0.472079325499629 576 3980186 SGTC_162 k030-0015 37.8 µM -0.0718336495493016 0.466273889058853 no 1819 0.471367146757274 583 1809920 YMR134W ERG29 SGTC_1489 4065-0444 182 µM -0.0718914149421081 0.466254639989688 no 1820 0.471344161127899 576 2877968 SGTC_2484 5809818 12.04 µM -0.0720689079243846 0.466195494782084 no 1821 0.471273534872467 584 2870548 SGTC_2855 9016525 58.44 µM -0.0733480790733868 0.465769264351318 no 1822 0.470764566568315 583 43811474 SGTC_3245 9134821 49.47 µM -0.0734523626998276 0.465734517906858 no 1823 0.470723075340183 590 17014901 SGTC_2872 9044037 25.97 µM -0.0758657181549103 0.464930481282454 no 1824 0.46976296558864 575 6465195 SGTC_876 0720-0963 56.8 µM -0.0762425925619567 0.464804934158543 no 1825 0.469613048659077 578 765861 SGTC_1014 4130-3005 69.3 µM -0.0773729444866358 0.464428404225873 no 1826 0.469163431709005 596 743608 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0775773727666635 0.464360310801864 no 1827 0.469082121021135 589 5282362 SGTC_2341 7987486 176.74 µM -0.0778273045541214 0.464277061942121 no 1828 0.468982713212532 576 1258686 SGTC_3214 9129694 49.47 µM -0.0781283714165719 0.464176782765226 no 1829 0.468862969519645 582 17158655 SGTC_1023 4482-3888 16 µM -0.0782620109843569 0.464132270903935 no 1830 0.468809817792209 574 3303168 SGTC_2932 9016711 44.54 µM -0.0792961159389329 0.463787852681292 no 1831 0.468398547803579 601 7117328 SGTC_158 k038-0087 26.446 µM -0.0803796839077673 0.463426989463708 no 1832 0.467967642254305 581 X158 SGTC_1447 4239-0816 81.9 µM -0.0816439580003573 0.46300598331293 no 1833 0.467464922262046 584 1341554 SGTC_2112 5488546 200 µM -0.0830490260570726 0.462538141082629 no 1834 0.466906278533827 594 600757 SGTC_889 0919-1524 82.7 µM -0.0841920883518327 0.462157576494617 no 1835 0.466451854218257 610 3905452 SGTC_3131 9127911 49.47 µM -0.0844277084458064 0.462079134790125 no 1836 0.466358188887173 623 45595681 SGTC_67 0335-0847 266 µM -0.0855744199252262 0.461697397277472 no 1837 0.465902366895679 646 4552207 YOR254C SEC63 SGTC_181 1447-1644 8.07 µM -0.0857136544493647 0.461651048832152 no 1838 0.465847023698237 598 534600 SGTC_2306 7482397 179.52 µM -0.0871506062588299 0.461172746263267 no 1839 0.46527590019747 598 891448 SGTC_550 4123-0385 25.7 µM -0.0893120946129752 0.460453381060932 no 1840 0.464416941186002 611 5731123 SGTC_3209 9113616 49.47 µM -0.0924609720469284 0.459405634999677 no 1841 0.46316589907193 592 16649353 SGTC_2995 9067767 71.4286 µM -0.0944556829710956 0.45874206749416 no 1842 0.462373592429534 607 11673567 SGTC_2763 lisinopril 49.32 µM -0.0948557381809494 0.458608997509686 no 1843 0.46221470687335 610 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1684 st024538 14.6195 µM -0.0948806586642827 0.458600708386297 no 1844 0.462204809676522 589 6732859 SGTC_935 2996-0153 430 µM -0.0971784740494025 0.457836480196115 no 1845 0.461292331172445 592 23738523 SGTC_668 1682-0499 62.6 µM -0.0972522314567576 0.457811951858238 no 1846 0.461263044941175 584 682214 SGTC_2786 7743617 45.45 µM -0.0973339292092766 0.457784783112539 no 1847 0.461230606149281 605 583674 SGTC_3255 9139072 49.47 µM -0.0997486242556187 0.456981861220092 no 1848 0.460271948218204 591 17646060 SGTC_131 0141-0277 33.849 µM -0.100233653934694 0.456820602733913 no 1849 0.460079414282766 611 1547771 SGTC_2692 st077426 47.7 µM -0.101194201851338 0.456501269052668 no 1850 0.459698149672477 594 25238571 SGTC_432 NS 1619 61.3 µM -0.101304984742109 0.456464441138099 no 1851 0.459654179650932 589 4552 A K+/calcium channel activator. SGTC_446 go6976 132 µM -0.104271898360298 0.455478280574443 no 1852 0.458476789092326 588 3501 A protein kinase C inhibitor. SGTC_2724 maprotiline 69.64 µM -0.104567143952393 0.455380159976398 no 1853 0.458359643531569 576 4011 A tricyclic antidepressant. SGTC_3135 9127742 49.47 µM -0.105749805364104 0.454987146925547 no 1854 0.457890431448844 599 3643468 SGTC_3270 9137563 49.47 µM -0.10662097103565 0.45469767592706 no 1855 0.457544840469762 585 17015724 SGTC_416 estradiol valerate 100 µM -0.107778460183919 0.454313102581717 no 1856 0.457085714813796 603 13791 A steroid. SGTC_3111 9122088 49.47 µM -0.109624879326076 0.453699722479116 no 1857 0.456353439361987 596 16876704 SGTC_1660 st012960 28.1 µM -0.110796076423099 0.453310708160698 no 1858 0.455889028378628 602 24207266 SGTC_345 1362-0200 395 µM -0.111722423170408 0.453003052848074 no 1859 0.455521749758533 615 1419823 SGTC_844 0330-0132 15.3 µM -0.112315724861369 0.452806022199483 no 1860 0.455286537028418 603 2828079 SGTC_2298 7976326 193.81 µM -0.112904054338265 0.452610654256061 no 1861 0.455053310994782 592 2235818 SGTC_2273 7815444 169.05 µM -0.113363252432034 0.452458175241732 no 1862 0.454871286085818 602 2824616 SGTC_912 3474-0017 2.18 µM -0.114723646094491 0.452006490987765 no 1863 0.454332085400244 607 3360550 SGTC_3170 9103054 49.47 µM -0.114774544754971 0.451989592578761 no 1864 0.45431191301916 621 16432970 SGTC_2830 7992007 71.43 µM -0.1152541771686 0.451830358386987 no 1865 0.454121828785056 582 1952075 SGTC_990 3985-0011 41.3 µM -0.115531755627331 0.451738208058601 no 1866 0.45401182581976 627 5399565 YGL099W LSG1 SGTC_213 1246-0773 967 nM -0.115998671333802 0.451583207533762 no 1867 0.453826797404955 617 6251622 SGTC_918 glabranin 770.725 nM -0.116032814608391 0.451571873388598 no 1868 0.453813267569648 619 124049 Also referred to as licorice root. SGTC_992 3909-8734 162 µM -0.116651158383401 0.45136661584839 no 1869 0.453568247948119 630 4288319 SGTC_1834 st055981 52.8 µM -0.116759597330195 0.451330621172377 no 1870 0.453525280676277 604 471719 YDL150W RPC53 SGTC_696 1560-0013 611 µM -0.117655357478928 0.451033302407874 no 1871 0.453170370290409 608 1650269 SGTC_1142 3253-1408 9.78 µM -0.119942198861256 0.450274383953946 no 1872 0.452264467946077 597 256655 SGTC_2103 5378138 10 µM -0.121549610702624 0.449741051782355 no 1873 0.451627861152478 595 244142 SGTC_282 k297-0036 65.7 µM -0.121619900278527 0.449717732074978 no 1874 0.451600026171233 615 5061378 SGTC_3315 9136395 68.55 µM -0.121706547971502 0.449688985535794 no 1875 0.451565713631145 606 16876844 SGTC_936 3005-4620 401 µM -0.122218836194667 0.449519032417822 no 1876 0.451362854579825 596 777207 SGTC_2062 5245942 200 µM -0.123315430992937 0.449155265047465 no 1877 0.450928660964729 601 1376160 SGTC_3202 9113761 49.47 µM -0.123691946083604 0.449030375603582 no 1878 0.450779594391206 609 4798415 SGTC_2020 4017018 200 µM -0.126728013153097 0.448023502675309 no 1879 0.449577836649332 612 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_180 1486-1293 102.781 µM -0.128101095831396 0.447568246864067 no 1880 0.449034484423291 625 4140536 SGTC_2480 5767542 37.17 µM -0.129113978854082 0.447232462167854 no 1881 0.448633730533837 602 2867358 SGTC_2301 7769476 200 µM -0.129356381921023 0.447152107806403 no 1882 0.448537829908271 618 977820 SGTC_1284 0929-0043 16 µM -0.13011880349111 0.446899386306183 no 1883 0.448236216779441 602 1239883 SGTC_2297 7971671 152.32 µM -0.130230090046781 0.446862499715676 no 1884 0.448192194439528 618 909016 SGTC_3038 9091290 49.47 µM -0.132632472222007 0.446066328464334 no 1885 0.44724202508492 600 25236843 SGTC_2593 nobiletin 86.24 µM -0.132801519490035 0.446010312815858 no 1886 0.447175176312952 602 72344 An anti-infammatory. SGTC_670 4204-0025 119 µM -0.133733011313942 0.445701672239159 no 1887 0.446806850185383 611 719039 SGTC_2420 aureobasidin a 50 nM -0.135115462077553 0.445243671596272 no 1888 0.446260292656662 634 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1705 st027868 56.3335 µM -0.136246828279198 0.444868908651433 no 1889 0.445813078339124 621 292948 SGTC_910 3454-3003 490 µM -0.136857700494001 0.444666578832303 no 1890 0.445571637133783 620 820824 SGTC_1100 amiodarone 5.07 µM -0.137216006454779 0.444547909357996 no 1891 0.44543002963004 605 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_80 0159-0065 512.242 µM -0.137723985013312 0.444379677449971 no 1892 0.445229281368 607 1548079 SGTC_1274 0865-0114 173 µM -0.139268984872814 0.443868067415155 no 1893 0.444618798745075 601 870624 SGTC_92 0063-0024 660.874 µM -0.139781285573472 0.443698445172555 no 1894 0.444416400031203 599 3594437 SGTC_2952 9073731 13.78 µM -0.140692108764561 0.443396898027657 no 1895 0.444056589689693 616 16457353 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.141402814160416 0.44316162683751 no 1896 0.443775865615345 596 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1701 st028638 40.4 µM -0.142558869900918 0.4427789701646 no 1897 0.443319291337236 614 3490878 SGTC_2629 bisabolol 100 µM -0.144569481148727 0.442113581307508 no 1898 0.442525397279508 614 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2441 5730946 39.09 µM -0.144924205492546 0.441996206224379 no 1899 0.442385357484973 603 1774275 SGTC_2160 5660466 132.927 µM -0.145393293955102 0.441840996908368 no 1900 0.442200179527187 672 2859134 SGTC_1952 st077036 64.1 µM -0.14539933430533 0.441838998369901 no 1901 0.442197795113126 623 2937007 SGTC_3013 9080133 71.4286 µM -0.145400099199673 0.441838745293495 no 1902 0.44219749317303 608 17050193 SGTC_1254 0550-0035 264 µM -0.145865291862606 0.441684833944086 no 1903 0.442013865780172 635 15121435 SGTC_1946 st076057 65.1 µM -0.147311004593091 0.441206568864687 no 1904 0.441443273415757 616 953009 SGTC_253 dyclonine 31.25 µM -0.149437047107294 0.440503395645619 no 1905 0.440604390274998 608 3180 An oral anasthetic. SGTC_1712 st032288 53.4 µM -0.150108858575182 0.440281237747252 no 1906 0.440339365522538 624 2883011 SGTC_587 k089-0003 57 µM -0.150946590244264 0.440004238889328 no 1907 0.44000892390805 604 9659696 SGTC_167 3672-0051 66.205 µM -0.151105985309883 0.439951537683527 no 1908 0.439946055561291 622 3237971 SGTC_2074 5212007 75.395 µM -0.151328951383141 0.439877819615126 no 1909 0.439858116180239 596 758611 SGTC_78 0336-0123 156.75 µM -0.153129420508828 0.439282616824347 no 1910 0.43914810763349 603 6765896 SGTC_2138 5575593 77.673 µM -0.153133545516833 0.439281253327775 no 1911 0.439146481175234 623 762213 SGTC_346 4513-0042 7.16 µM -0.153316922084552 0.439220640034924 no 1912 0.439074178273357 627 2827372 SGTC_1908 st060353 56.5 µM -0.157053755304817 0.437985779509445 no 1913 0.437601241556466 649 4227716 SGTC_2639 lactacystin 53 µM -0.157715831185434 0.437767054891494 no 1914 0.437340362572961 620 3870 A proteasome inhibitor. SGTC_2061 5245884 80.95 µM -0.157909612276541 0.437703040604165 no 1915 0.437264011799408 635 573863 SGTC_31 0508-1974 57.237 µM -0.158386097858733 0.437545643715949 no 1916 0.437076283903828 602 6810525 SGTC_2231 micatex 6.853 µM -0.15959464066785 0.437146471652935 no 1917 0.436600200497823 623 20737 An antifungal of unknown mechanism. SGTC_2177 5811945 192 µM -0.160280390589745 0.436920002339301 no 1918 0.436330102605034 600 5343475 SGTC_2253 7938677 135.83 µM -0.161898020477559 0.436385861141526 no 1919 0.435693080842393 627 2301972 SGTC_1040 k898-0338 155 µM -0.161956722143998 0.436366480033122 no 1920 0.435669967285003 605 20969351 SGTC_1101 ebselen 5.29 µM -0.163202796204652 0.435955108806567 no 1921 0.435179382336749 613 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1926 methyl fluorone black 53.6 µM -0.16428968487515 0.435596346616743 no 1922 0.434751550819806 607 72721 Reacts with homocysteine. SGTC_1050 3232-1156 69.3 µM -0.165280760489972 0.43526925676201 no 1923 0.434361500726548 614 700529 SGTC_166 k072-0058 166.424 µM -0.165892221641735 0.43506747512414 no 1924 0.434120884454512 608 5846229 SGTC_2722 naftopidil 47.16 µM -0.166762165425732 0.434780423600165 no 1925 0.433778594683512 650 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_6 0844-0013 19.835 µM -0.166959128191153 0.434715437429781 no 1926 0.433701104215891 626 1584900 SGTC_1555 citronellol 128 µM -0.167080770415471 0.434675303505003 no 1927 0.433653248154573 615 8842 A terpine precursor. SGTC_493 zm226600 134 µM -0.167803647332538 0.434436815618329 no 1928 0.433368876516506 656 5240098 A potassium channel opener. YCR052W RSC6 SGTC_255 tunicamycin 200.472 nM -0.168609804077762 0.434170880615003 no 1929 0.433051784220599 636 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3075 9116269 49.47 µM -0.168704563522928 0.434139623321592 no 1930 0.433014514531645 638 17015205 YNL244C SUI1 SGTC_1667 st014849 34.6 µM -0.16910099131697 0.434008862355579 no 1931 0.432858602600721 610 5348460 SGTC_618 k072-0232 33.2 µM -0.170212415663813 0.433642299660441 no 1932 0.432421543955642 640 5872756 YGL099W LSG1 SGTC_2712 st079126 47.7 µM -0.17234895210116 0.432937801772359 no 1933 0.431581600936258 641 3152970 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.172650994591788 0.432838223935725 no 1934 0.43146288292264 623 88881 An O-methylated flavonoid and antioxidant. SGTC_2187 6125751 200 µM -0.173156119029273 0.432671703260895 no 1935 0.431264357245767 631 874498 SGTC_357 1325-0123 420 µM -0.173198749158982 0.43265765024488 no 1936 0.431247603405054 666 1098503 SGTC_3243 9134147 49.47 µM -0.17501377806911 0.432059405470714 no 1937 0.43053440367093 636 24282180 SGTC_966 1300-0360 30.2 µM -0.175484556941231 0.431904259221803 no 1938 0.430349452135462 642 70588 SGTC_566 0958-0068 16.5 µM -0.175775336417386 0.431808437428568 no 1939 0.430235223308537 663 6815365 SGTC_33 0986-0033 35.816 µM -0.175775559695304 0.43180836385239 no 1940 0.430235135599036 610 2848082 SGTC_1198 1612-1005 86.7 µM -0.175925555393489 0.431758936704006 no 1941 0.430176214080063 624 6998509 SGTC_3077 9117319 49.47 µM -0.176010079552715 0.431731084454729 no 1942 0.430143011867021 617 17154678 SGTC_2983 9022671 12.99 µM -0.177498808156241 0.431240577028498 no 1943 0.429558300661781 676 6405161 SGTC_3125 9127534 49.47 µM -0.177559306001212 0.431220646389515 no 1944 0.429534542861066 604 1639235 SGTC_2355 9061122 103.12 µM -0.177656156593768 0.431188739928425 no 1945 0.429496509689251 650 5302957 SGTC_520 3584-0023 682 µM -0.17906793446918 0.430723694882649 no 1946 0.428942179803933 617 1340790 SGTC_1129 3453-1384 223 µM -0.179731335664936 0.430505201116629 no 1947 0.428681745857758 694 1084452 SGTC_2516 gossypol 71.55 µM -0.180588512072583 0.430222918241585 no 1948 0.428345286830986 653 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2518 prenyletin 46.28 µM -0.182060600300147 0.429738217651094 no 1949 0.427767584165448 611 3873459 A coumarin with calcium channel inhibitory activity. SGTC_479 n-linoleoylglycine 10 µM -0.18354801276137 0.429248578938288 no 1950 0.427184024934383 645 6433346 An anti-infammatory. SGTC_1233 0325-0408 14.2 µM -0.18707875746465 0.42808673639955 no 1951 0.425799441600167 650 12874 SGTC_2662 daunorubicin 22.37 µM -0.187241479120703 0.428033205433157 no 1952 0.425735652130764 606 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_279 1273-0055 2.93 µM -0.187761346833243 0.427862192079329 no 1953 0.425531868775356 636 2847562 SGTC_200 k038-0079 37.545 µM -0.189637884977374 0.427245007454374 no 1954 0.424796448971098 629 3436683 SGTC_1803 st050068 52.4 µM -0.192488437871926 0.426307815029349 no 1955 0.423679811905595 638 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_591 4299-0174 154 µM -0.193758027008414 0.425890538596462 no 1956 0.423182676853779 644 5509088 SGTC_468 gf-109203x 121 µM -0.196316535024859 0.425049885159301 no 1957 0.422181210062645 644 2396 A protein kinase C inhibitor. SGTC_801 0866-0028 10.1 µM -0.197067068961562 0.42480334537642 no 1958 0.42188752661441 614 6849771 SGTC_817 1391-0715 46 µM -0.198128150943739 0.424454845157161 no 1959 0.42147240006238 645 1353946 SGTC_146 3448-8650 53.125 µM -0.19889362419351 0.424203470889031 no 1960 0.421172978518331 669 2891488 YIL048W NEO1 SGTC_2118 5526350 200 µM -0.201163782828241 0.423458153676795 no 1961 0.42028525484959 655 743594 SGTC_511 blebbistatin 171 µM -0.202364576177259 0.423064030993806 no 1962 0.41981585978991 651 3476986 A myosin inhibitor. SGTC_1152 3909-8331 15.9 µM -0.203310665660676 0.422753561051561 no 1963 0.419446109813891 640 16001939 SGTC_2795 7780010 54.55 µM -0.20462651087333 0.422321831398084 no 1964 0.418931970488109 634 953673 SGTC_1318 1280-3875 124 µM -0.204745160046019 0.422282907107423 no 1965 0.41888561756617 659 373245 SGTC_1305 1181-0477 144 µM -0.206282477377154 0.42177864039666 no 1966 0.418285132608672 633 6252086 SGTC_554 4483-2211 187 µM -0.207723040274836 0.421306227177302 no 1967 0.41772261326046 634 747107 SGTC_1494 4358-1428 177 µM -0.208067336595796 0.421193336575605 no 1968 0.417588195314978 668 1564571 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.209186887190895 0.420826294299244 no 1969 0.417151174244415 665 7104 SGTC_1932 st074806 40.9 µM -0.209292364122116 0.420791717454202 no 1970 0.417110006167516 628 17251235 SGTC_902 1120-0002 2.07 µM -0.209814577433188 0.420620537476424 no 1971 0.416906197576575 660 3280475 SGTC_818 4072-2707 53.5 µM -0.211870215783691 0.419946851437424 no 1972 0.416104143725178 628 882871 SGTC_909 3448-9333 149 µM -0.212388151057527 0.419777147514929 no 1973 0.415902114504985 644 3344074 SGTC_387 norethindrone acetate 66.7 µM -0.212857556757161 0.419623357420287 no 1974 0.41571903424337 669 541197 SGTC_2531 methyl deoxycholate 70.07 µM -0.212995309572346 0.419578228174156 no 1975 0.415665310582434 665 16667744 Haematoxylin. SGTC_63 0099-0242 26.702 µM -0.213132395785761 0.41953331836373 no 1976 0.415611848461335 662 3898502 YLR359W ADE13 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.214443485471856 0.419103854901975 no 1977 0.415100616896075 649 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1713 st033146 12.748 µM -0.21465984205461 0.419032993907201 no 1978 0.415016267036066 684 674619 SGTC_3305 9127027 53.8275 µM -0.215288974985496 0.418826955549766 no 1979 0.414771012394495 648 41905295 SGTC_1088 bifonazole 369 nM -0.21647756512939 0.418437758142448 no 1980 0.414307755499865 635 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.217063264328141 0.41824600345019 no 1981 0.414079521117925 635 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_156 3474-0145 5.642 µM -0.21733548023672 0.418156888071725 no 1982 0.413973454304259 620 2265471 SGTC_1372 2752-0194 270 µM -0.218100496623387 0.417906467007932 no 1983 0.413675405234551 656 823334 SGTC_414 piperonyl butoxide 100 µM -0.21916810738983 0.41755705011521 no 1984 0.413259549068927 656 5794 A potent inhibitor of cytochrome P450. SGTC_2456 5770359 74.46 µM -0.219767057941474 0.417361048876217 no 1985 0.413026288188466 635 3118787 SGTC_859 0439-0102 54.6 µM -0.22003442756067 0.417273561172814 no 1986 0.412922171181025 651 610143 SGTC_1009 4106-0057 9.87 µM -0.220350986578826 0.417169983190716 no 1987 0.412798907138199 630 2928005 SGTC_2788 5282734 71.43 µM -0.22040074916331 0.417153701415946 no 1988 0.41277953100442 681 743706 SGTC_563 tetrahydrosecaminediol 614 µM -0.222295217995022 0.416533957790644 no 1989 0.412042037236426 660 334274 A psychoactive constituent of the cannabis plant. SGTC_1571 st070080 73.4 µM -0.222406350892095 0.416497608957629 no 1990 0.41199878416326 648 4315245 SGTC_3233 9132340 49.47 µM -0.222431564355896 0.416489362354085 no 1991 0.41198897119797 692 17682950 SGTC_1276 0871-0068 94.2 µM -0.222433782391666 0.416488636899723 no 1992 0.411988107951183 632 3414906 SGTC_1816 st051957 91.6 µM -0.222899041570092 0.416336470577533 no 1993 0.411807041170733 652 674121 SGTC_1808 st050063 61.5 µM -0.223054804409094 0.41628553003395 no 1994 0.411746426515497 670 4011993 SGTC_2440 5628896 157.78 µM -0.223184281180943 0.416243187133116 no 1995 0.41169604260953 638 5522048 SGTC_2347 9049783 174.81 µM -0.22396243107788 0.41598872859144 no 1996 0.41139326817274 690 6467988 YPL169C MEX67 SGTC_812 4251-0442 148 µM -0.225015326301581 0.415644483161169 no 1997 0.410983675657946 673 5723007 SGTC_1927 st060202 13.8 µM -0.225170247073769 0.415593837074336 no 1998 0.410923417261449 642 688887 SGTC_3100 9120536 49.47 µM -0.22677117240872 0.415070551145586 no 1999 0.41030084042048 691 16421196 SGTC_2224 6650123 117.647 µM -0.226838210960362 0.415048641891193 no 2000 0.410274775010842 647 2908370 SGTC_861 0443-0273 110 µM -0.227275997975032 0.414905572699562 no 2001 0.410104567810724 645 6149169 SGTC_3194 9111903 49.47 µM -0.227590876629188 0.414802677047464 no 2002 0.40998215661694 668 17087251 SGTC_1497 4476-2978 41.3 µM -0.229488898736937 0.414182567803835 no 2003 0.409244473972213 629 1528379 SGTC_852 0418-0143 439 µM -0.231262198395992 0.413603400271666 no 2004 0.408555556007072 646 5369229 SGTC_1115 galangin 695.678 nM -0.231359630886254 0.413571583822819 no 2005 0.408517712144045 687 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2339 9000433 200 µM -0.231715838771166 0.413455269447426 no 2006 0.408379364302145 630 2988954 SGTC_120 rhodamine 6G 52.259 µM -0.23261473824659 0.41316178100792 no 2007 0.408030290878032 655 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_132 0417-1715 25.805 µM -0.233273674984303 0.412946670616243 no 2008 0.407774449539628 669 6769098 SGTC_2076 5212012 200 µM -0.235354290909792 0.412267623832198 no 2009 0.406966880118445 633 604802 SGTC_3190 9110366 49.47 µM -0.235700417531073 0.412154684542431 no 2010 0.406832572939001 682 17123768 SGTC_1879 gemcitabine 100 µM -0.235760938293306 0.412134937684078 no 2011 0.40680909025088 650 60750 A nucleoside analog which inhibits DNA replication. SGTC_303 1348-1668 34.2 µM -0.236054088864803 0.412039290967228 no 2012 0.406695349509638 660 5380509 SGTC_1529 apigenin 74 µM -0.239232482905367 0.41100260772518 no 2013 0.405462658053525 697 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.239864658364815 0.410796487591549 no 2014 0.405217589820583 641 368090 SGTC_946 3434-1334 87.4 µM -0.23987600001505 0.410792789883335 no 2015 0.405213193471729 646 4047976 SGTC_286 k060-0067 22.9 µM -0.240603013123155 0.410555778997124 no 2016 0.404931407323522 642 5985051 SGTC_3160 9100216 49.47 µM -0.244562949221651 0.409265390282828 no 2017 0.403397427593762 647 17191039 SGTC_2429 5902844 64.44 µM -0.246142865572124 0.408750830585554 no 2018 0.402785820834143 670 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3226 9131256 49.47 µM -0.247139183138967 0.408426422760112 no 2019 0.402400255144559 638 17178073 SGTC_2524 avocatin b 10.57 µM -0.247979405590876 0.408152889332599 no 2020 0.402075170589616 656 6710748 SGTC_1182 1222-0449 220 µM -0.248437032710347 0.408003928180251 no 2021 0.401898141777177 639 658318 SGTC_1742 st038235 28.8875 µM -0.248456855322026 0.40799747606775 no 2022 0.401890474037964 665 564103 YBR002C RER2 SGTC_1554 st069299 38.7 µM -0.248869779137946 0.407863078115638 no 2023 0.401730756343325 654 24207999 SGTC_290 2043-6722 48.1 µM -0.249855707959865 0.407542223049857 no 2024 0.401349468454636 661 773758 YLR208W SEC13 SGTC_1530 rhein 70.4 µM -0.252563489507936 0.406661337682554 no 2025 0.400302773296515 648 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1067 clotrimazole 1.36 µM -0.254814167907026 0.40592951445559 no 2026 0.399433316000894 643 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_322 k048-0136 19.3 µM -0.255451552292418 0.405722324229093 no 2027 0.399187179080723 646 6823282 SGTC_1436 4092-1007 8.32 µM -0.25664810699365 0.405333439659366 no 2028 0.398725217246655 638 2881121 SGTC_1657 st012939 43.4 µM -0.257725414759612 0.404983390693304 no 2029 0.398309415196827 653 24207257 SGTC_1353 1498-1206 8.11 µM -0.258259174735254 0.404809984527006 no 2030 0.398103445779594 663 6756808 SGTC_2200 6600604 21.907 µM -0.258513182184556 0.404727469993302 no 2031 0.398005438343899 694 2904777 SGTC_605 1315-0399 119 µM -0.258901097533284 0.404601463542203 no 2032 0.397855775671453 657 24020461 SGTC_2533 agelasine 13.65 µM -0.259221159794168 0.404497505241853 no 2033 0.397732302898388 665 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1704 st028805 70.8 µM -0.259330650633509 0.404461943453686 no 2034 0.39769006616273 661 2876101 SGTC_465 cgp-37157 41 µM -0.259739207237458 0.404329254359432 no 2035 0.397532473638581 656 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_807 1315-0151 48 µM -0.259973469798907 0.404253176628229 no 2036 0.397442119090872 690 4011080 SGTC_11 0438-0307 1.3 µM -0.260020747783104 0.404237823347233 no 2037 0.397423884744932 666 4011476 SGTC_2752 diclazuril 33.15 µM -0.260136742132525 0.404200155406702 no 2038 0.397379148569527 668 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_733 4069-0007 56.1 µM -0.262136085037935 0.40355102977686 no 2039 0.396608263684303 652 5717425 YNL287W SEC21 SGTC_1487 3970-0795 2.82 µM -0.26336250477806 0.403152980025144 no 2040 0.39613559379524 659 3765103 SGTC_175 3793-3120 23.7 µM -0.26455369213934 0.402766461421488 no 2041 0.39567664881039 715 5322297 SGTC_1979 st071809 45.3 µM -0.265991768765849 0.402299958367579 no 2042 0.395122774159258 700 4976333 SGTC_3203 9113543 49.47 µM -0.266094286946416 0.402266707416072 no 2043 0.395083297398075 655 17018012 SGTC_3191 9110352 49.47 µM -0.268025705937118 0.401640399543644 no 2044 0.394339765965359 662 17122424 SGTC_122 0236-0016 402.397 µM -0.268670547228026 0.401431350801168 no 2045 0.394091609286045 664 6808838 SGTC_2379 9035213 200 µM -0.270987230784951 0.400680546746356 no 2046 0.393200426649812 642 646551 SGTC_622 1348-1566 26.3 µM -0.271059775418204 0.400657041974853 no 2047 0.393172529163163 680 7340407 SGTC_530 4358-1714 28 µM -0.271410064648647 0.400543551828867 no 2048 0.393037830998621 649 1564641 SGTC_403 arphamenine a 50 µM -0.272681003282876 0.400131851204401 no 2049 0.392549219346394 692 5487158 An arginine aminopeptidase inhibitor. SGTC_1415 3966-0071 78.1 µM -0.275384813536033 0.399256363977791 no 2050 0.39151030512418 685 2893185 SGTC_1703 st026983 48.3 µM -0.276464715893851 0.398906835486965 no 2051 0.391095578282533 676 1104023 SGTC_2069 5228469 200 µM -0.277785488979056 0.398479455358299 no 2052 0.390588515537577 697 2835210 SGTC_2784 7567673 72.73 µM -0.279153595413601 0.398036887301557 no 2053 0.390063477007734 674 3471247 SGTC_1521 st012942 49.4 µM -0.282681487532258 0.39689625772802 no 2054 0.388710504248142 666 24207259 SGTC_2505 galangin 7.89 µM -0.283235365288092 0.396717259121882 no 2055 0.388498210116914 691 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_206 4546-0025 72.014 µM -0.283942188184846 0.39648886431039 no 2056 0.3882273424777 717 6620745 YIL048W NEO1 SGTC_1793 st048256 72.231 µM -0.284250879890775 0.396389128277199 no 2057 0.388109063138736 672 672022 SGTC_2374 9071832 200 µM -0.284296575936187 0.39637436479498 no 2058 0.388091554971854 694 17381698 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.284532786475133 0.396298052243713 no 2059 0.388001055942008 680 4213774 SGTC_1837 st055472 66.5 µM -0.284869689209536 0.396189215934832 no 2060 0.387871989370199 670 676091 SGTC_2568 diosmetin 100 µM -0.286497968521417 0.395663315068741 no 2061 0.38724837458917 685 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_664 1222-0054 14.9 µM -0.286649213406472 0.395614475693314 no 2062 0.38719046404182 661 6813991 SGTC_2680 butyl paraben 22.24 µM -0.28693664892885 0.395521662716348 no 2063 0.387080414027725 671 7184 An antifungal and steroid mimetic. SGTC_2962 9082311 13.18 µM -0.287940124354955 0.395197686820943 no 2064 0.386696286079729 664 16459453 SGTC_2708 st078559 56 µM -0.289235978546195 0.394779422506635 no 2065 0.386200400489747 672 17250902 SGTC_2914 7968218 45.32 µM -0.289853080505403 0.394580282401406 no 2066 0.385964318845558 700 2977111 SGTC_872 0588-0139 234 µM -0.291779869322957 0.393958681072839 no 2067 0.385227468888595 643 2047100 SGTC_96 0929-0093 37.281 µM -0.291902591335841 0.393919098856412 no 2068 0.385180551068902 673 6991579 SGTC_2588 indole-3-carbinol 100 µM -0.291963004086949 0.393899613996772 no 2069 0.385157455303583 693 3712 Induces cell cycle arrest. SGTC_485 niflumic acid 177 µM -0.292289883188664 0.39379419063939 no 2070 0.385032496649382 681 4488 A COX2 inhibitor. SGTC_2026 5148700 152 µM -0.292508602034568 0.393723654914184 no 2071 0.384948891935655 655 79838 SGTC_689 0833-0039 98 µM -0.294775260885916 0.392992874576224 no 2072 0.384082783050771 717 5374726 SGTC_1351 1496-0003 46.5 µM -0.295876205147361 0.392638061371466 no 2073 0.383662311724931 671 3891978 SGTC_1631 benzylvanillin 81.9 µM -0.296176876206181 0.392541176355909 no 2074 0.383547503578157 677 75506 SGTC_353 1988-1175 58.3 µM -0.297773315474095 0.392026868577155 no 2075 0.382938091164366 702 2788357 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.297927782543187 0.391977115564643 no 2076 0.38287914144186 676 77254 SGTC_3094 9117742 49.47 µM -0.300418642716623 0.391175067314398 no 2077 0.381928922610543 678 17149698 SGTC_1623 st003709 20.3 µM -0.302408226484121 0.390534760418233 no 2078 0.381170442162481 645 16192618 SGTC_1221 2958-7315 257 µM -0.303375758597256 0.390223487106139 no 2079 0.38080175876733 678 4562705 SGTC_2608 thymoquinone 42.66 µM -0.303398826503223 0.390216066584157 no 2080 0.380792969935181 677 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2976 9009005 19.48 µM -0.303418648136471 0.390209690360482 no 2081 0.380785417976441 658 2993148 SGTC_3292 9120825 59.784 µM -0.304097061534335 0.389991476130227 no 2082 0.380526972728246 684 24824900 SGTC_1320 1313-0481 95.3 µM -0.304155125158874 0.389972801355613 no 2083 0.380504855552042 698 6813365 YLR208W SEC13 SGTC_649 1123-0311 367 µM -0.304218029159653 0.389952570076469 no 2084 0.380480895055499 698 693629 YIL048W NEO1 SGTC_1842 st055362 61.2 µM -0.304250694636296 0.389942064274438 no 2085 0.380468452767996 659 676032 SGTC_2068 5226020 147 µM -0.304400524941632 0.389893877196364 no 2086 0.380411383955099 704 1810509 SGTC_139 0099-0334 718.624 µM -0.304726723009231 0.38978897415474 no 2087 0.380287147489727 680 97690 SGTC_506 n9-isopropylolomoucine 153 µM -0.305572346863169 0.389517064772181 no 2088 0.379965138982846 705 6610355 SGTC_3054 9094397 49.47 µM -0.307791588894124 0.388803727537524 no 2089 0.379120461096371 708 2598354 SGTC_204 PMA1.184 62.41 µM -0.308330018759796 0.388630714903046 no 2090 0.378915613150926 679 2252213 YGL008C PMA1 SGTC_1867 st057372 64 µM -0.308971839486246 0.388424508743796 no 2091 0.378671474141057 678 688837 SGTC_574 1315-0397 40 µM -0.309215561453387 0.388346213225993 no 2092 0.378578778624772 675 6794277 SGTC_2257 7960413 200 µM -0.311796553724052 0.387517350209127 no 2093 0.377597571655561 671 2974689 YIL048W NEO1 SGTC_959 1222-0044 107 µM -0.312459458499249 0.387304546713608 no 2094 0.377345684584367 693 6083612 SGTC_1831 st055328 12 µM -0.312625680784205 0.387251191893415 no 2095 0.377282532491122 702 1103068 SGTC_3017 9080681 49.47 µM -0.313720291273426 0.386899891846657 no 2096 0.376866744030195 695 16451914 SGTC_2281 7943571 200 µM -0.3148761263147 0.386529043185289 no 2097 0.376427854353396 693 1244024 SGTC_692 k241-0027 77.8 µM -0.317514310020719 0.385682972881187 no 2098 0.375426691489762 705 3600480 SGTC_3326 9140064 16.379 µM -0.317938500051507 0.385546984993801 no 2099 0.375265793917326 694 1868434 SGTC_333 3486-0131 40.1 µM -0.319426476133721 0.385070077277764 no 2100 0.374701568266677 675 6744690 SGTC_3147 9097027 49.47 µM -0.319866464444327 0.38492909091908 no 2101 0.374534780409876 675 25236841 SGTC_3195 9113082 49.47 µM -0.320385509959647 0.384762791657217 no 2102 0.374338054250003 674 17018038 SGTC_3219 9131112 49.47 µM -0.322461116133892 0.384097991293352 no 2103 0.373551695309954 693 17612988 YMR079W SEC14 SGTC_1058 3448-5425 97.3 µM -0.324010614551434 0.383601921209343 no 2104 0.37296499906194 691 7279705 SGTC_1765 st044815 90.4 µM -0.324105748621567 0.383571470355669 no 2105 0.372928987437941 678 645695 SGTC_1990 st072050 59.8 µM -0.325888526477931 0.383000965630573 no 2106 0.372254348393455 676 17233948 SGTC_2126 5251174 33.877 µM -0.327587803153445 0.38245741814668 no 2107 0.3716116725924 698 790722 SGTC_968 1309-0633 340 µM -0.327784495664606 0.382394517058769 no 2108 0.371537305464762 724 3761976 SGTC_1361 1608-0041 5.61 µM -0.328597730712072 0.382134482311792 no 2109 0.371229881767381 680 X1361 SGTC_1578 josamycin 24.2 µM -0.328656207832324 0.382115786095523 no 2110 0.371207779080154 723 5282165 A P450 substrate. SGTC_2216 7189485 200 µM -0.328683009359226 0.382107217243818 no 2111 0.371197649007698 683 731273 SGTC_1906 st060206 94.7 µM -0.329077347419265 0.381981148105718 no 2112 0.371048612851291 720 5133468 SGTC_1322 1348-1070 12 µM -0.329954210451708 0.381700861506279 no 2113 0.370717280512365 672 6758089 SGTC_596 1155-0152 116 µM -0.330202632369345 0.381621465463039 no 2114 0.370623428973142 687 280313 SGTC_208 k072-0098 12.366 µM -0.331117781720333 0.381329025253589 no 2115 0.37027776033376 711 5948901 SGTC_154 3389-1638 511.116 µM -0.331237769984141 0.381290687468613 no 2116 0.370232446333418 742 5238686 SGTC_3262 9137218 49.47 µM -0.332007752419656 0.381044695970068 no 2117 0.369941702576014 674 17650664 SGTC_185 k048-0037 25.491 µM -0.334684695765512 0.380189849383184 no 2118 0.368931473664891 694 6827589 SGTC_2731 amoxapine 43.43 µM -0.335763468978575 0.379845522483372 no 2119 0.368524619993233 702 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_350 k064-0020 19.8 µM -0.336599362822474 0.379578784208114 no 2120 0.368209468298712 699 2790705 SGTC_2493 resveratrol 26.09 µM -0.344806930858927 0.376962766400024 no 2121 0.36511976110055 677 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_742 0kpi-0133 140 µM -0.34489614698651 0.376934361092283 no 2122 0.365086223674851 713 2728852 SGTC_3183 9108214 49.47 µM -0.344899863755591 0.376933177733588 no 2123 0.36508482651861 708 4974831 SGTC_2191 5911152 200 µM -0.34553401771708 0.376731290382467 no 2124 0.364846470400392 692 2875902 SGTC_2156 5649887 115 µM -0.345588919258236 0.376713813677231 no 2125 0.364825837301626 694 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1758 st042942 75.2445 µM -0.346085528278448 0.376555740536638 no 2126 0.364639219477953 683 669317 SGTC_2132 5317594 122.667 µM -0.346155676857935 0.376533413559832 no 2127 0.364612861334214 690 794577 SGTC_1355 1499-0035 1.68 µM -0.346580866761913 0.376398092431888 no 2128 0.364453111050009 703 1548538 SGTC_1304 1165-0502 251 µM -0.347538968245947 0.376093222329959 no 2129 0.364093224139157 682 767425 SGTC_2741 miltefosine 3.04 µM -0.347936479421036 0.375966756037694 no 2130 0.36394394413785 698 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2008 4012253 172 µM -0.34952295156453 0.375462160247154 no 2131 0.363348371583039 684 603940 SGTC_2959 9079155 11 µM -0.350051875502902 0.375293977176067 no 2132 0.363149883219398 727 16189457 SGTC_1313 1220-0047 237 µM -0.35122229307114 0.374921901304019 no 2133 0.362710793355124 699 3528706 SGTC_2081 5214970 32.255 µM -0.351589819619698 0.374805088569052 no 2134 0.362572950554401 694 2063512 SGTC_1752 st044819 83.042 µM -0.352437461705214 0.374535722205844 no 2135 0.362255105785118 682 441209 YML126C ERG13 SGTC_1391 3442-0225 151 µM -0.354148667398466 0.373992116545775 no 2136 0.36161373556922 670 5227075 SGTC_9 0092-0002 10.449 µM -0.354744892151138 0.373802770198744 no 2137 0.361390358130332 696 759368 SGTC_2178 5812956 200 µM -0.357109315473899 0.373052187622812 no 2138 0.360504985467085 687 5403383 SGTC_3026 9090633 49.47 µM -0.358093551229823 0.372739885275208 no 2139 0.360136652438934 693 25236842 SGTC_756 0508-1999 28.3 µM -0.361254598888627 0.37173743746503 no 2140 0.358954564996726 703 6753853 SGTC_2862 9027634 71.43 µM -0.361732249040782 0.371586037988504 no 2141 0.358776062734261 685 5012562 SGTC_1759 st043059 70 µM -0.362048090738682 0.371485937407357 no 2142 0.358658046717832 730 669426 SGTC_2490 carminic acid 95.39 µM -0.364567752100289 0.370687685903784 no 2143 0.357717045244343 715 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_202 3594-0513 34.79 µM -0.364741136919512 0.370632776444785 no 2144 0.357652324061652 696 708429 SGTC_2363 9053361 176 µM -0.365272863639189 0.370464399669397 no 2145 0.357453866342835 730 6469797 YMR079W SEC14 SGTC_522 1273-0010 11.6 µM -0.365765645389618 0.370308377373982 no 2146 0.357269978563902 692 5705015 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.366362831061521 0.37011932778353 no 2147 0.357047175554773 693 803109 SGTC_2432 5630864 12.22 µM -0.367127845316173 0.369877194958314 no 2148 0.356761828880693 731 5714970 SGTC_56 0957-0365 83.25 µM -0.367547763244633 0.369744309661495 no 2149 0.356605235547106 704 6752360 SGTC_1385 3091-4834 14.1 µM -0.367996126420369 0.369602439882771 no 2150 0.356438061256922 699 4072814 SGTC_553 k007-0256 45.7 µM -0.368219666853064 0.369531714495723 no 2151 0.356354723471085 712 6287000 SGTC_2881 9058953 51.95 µM -0.36827584203149 0.36951394206834 no 2152 0.356333781962278 673 17122249 SGTC_786 4544-0069 423 µM -0.36874136512842 0.369366672886499 no 2153 0.356160256581345 682 748821 YLR208W SEC13 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.368877761297259 0.369323527309808 no 2154 0.356109420067315 724 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_187 1488-2104 32.728 µM -0.368913426528075 0.369312245761787 no 2155 0.356096127623034 682 2852859 SGTC_2939 9044578 71.43 µM -0.369905592934599 0.368998450994149 no 2156 0.355726417007234 697 2653634 SGTC_3280 9140961 49.47 µM -0.370545567797269 0.368796090960918 no 2157 0.35548801535626 714 4901226 SGTC_2595 hexamethylquercetagetin 100 µM -0.371751973742981 0.368414724377168 no 2158 0.355038762162289 749 386331 SGTC_277 nystatin 15.5 µM -0.372722270958278 0.368108090012725 no 2159 0.354677579569571 740 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1227 3909-8010 46.6 µM -0.372885489008262 0.368056517919103 no 2160 0.354616836248426 702 15982272 SGTC_2288 7946289 167.31 µM -0.372921840609576 0.36804503220815 no 2161 0.354603308119379 738 1246052 SGTC_40 0327-0103 19.753 µM -0.373999400082162 0.367704618383688 no 2162 0.354202381256788 693 409036 SGTC_1098 clofazimine 15.1 µM -0.375072261146004 0.367365792061777 no 2163 0.353803363016136 695 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2003 4023581 200 µM -0.376358226430918 0.366959800144175 no 2164 0.353325298666921 705 16641307 SGTC_348 k064-0012 10.7 µM -0.376458430513762 0.366928170968571 no 2165 0.353288056978647 701 5066323 SGTC_2173 5763948 167 µM -0.37776058782488 0.36651723038525 no 2166 0.35280422714894 707 2867177 SGTC_1343 1487-0095 224 µM -0.379906209589387 0.365840439450655 no 2167 0.352007518870872 744 4560101 YGL055W OLE1 SGTC_619 1652-1634 108 µM -0.380500834533683 0.365652951369442 no 2168 0.351786838591101 731 5400454 SGTC_1778 st046819 58.9 µM -0.381216858017816 0.365427228337775 no 2169 0.351521170518122 712 671715 SGTC_3238 9133470 49.47 µM -0.381821373594284 0.365236693925886 no 2170 0.351296931960807 707 3534688 SGTC_2190 6049624 200 µM -0.383218128489778 0.364796584616307 no 2171 0.350779018786686 730 2265554 SGTC_891 0929-0073 133 µM -0.38339738564007 0.364740114618559 no 2172 0.350712570738233 728 5603632 SGTC_2028 5153890 36.43 µM -0.385211445907008 0.36416881049944 no 2173 0.350040381932959 725 2830968 YPR165W RHO1 SGTC_398 bronopol 33.3 µM -0.386629589928207 0.363722402789395 no 2174 0.349515224368277 704 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2404 5161160 200 µM -0.386654370133159 0.363714604042974 no 2175 0.349506050485636 716 2831543 SGTC_1799 st045822 46.1415 µM -0.387341375211623 0.363498414506911 no 2176 0.349251749268719 742 3674992 SGTC_879 0831-1030 162 µM -0.387344995274938 0.363497275445807 no 2177 0.349250409448271 727 1549252 SGTC_491 tetrandrine 80.3 µM -0.387381435332417 0.36348580956658 no 2178 0.349236922735167 725 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_505 gw-5074 63.9 µM -0.388122815172588 0.363252560658647 no 2179 0.348962574373775 706 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_93 0109-0045 59.227 µM -0.390130116628077 0.362621289037811 no 2180 0.348220166965194 717 88733 SGTC_2545 solidagenone 89.61 µM -0.390226952046978 0.362590844913613 no 2181 0.348184366723406 672 6708572 An anti ulcer agent SGTC_1240 0356-0016 42.1 µM -0.390395803051935 0.362537761860139 no 2182 0.348121945416205 702 4305613 SGTC_2907 7721985 69.9 µM -0.392296531771172 0.361940396935242 no 2183 0.347419562966372 709 3267881 SGTC_1644 st010134 20.9 µM -0.392681102881655 0.361819573981573 no 2184 0.34727751476585 748 3818134 SGTC_644 1498-1197 63.3 µM -0.3933693782582 0.36160336887159 no 2185 0.347023341535273 715 6741615 SGTC_3050 9093513 49.47 µM -0.394028233793782 0.361396446678732 no 2186 0.346780097215494 728 25236664 SGTC_1760 st045453 10.4495 µM -0.394555775516315 0.361230794525031 no 2187 0.346585378443713 740 3323419 YIL048W NEO1 SGTC_2683 piperine 63.03 µM -0.395910053947358 0.360805659882072 no 2188 0.34608569192355 731 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1413 3910-0535 34.4 µM -0.395980153481873 0.360783658935041 no 2189 0.346059834664967 719 2876951 SGTC_478 N-arachidonylglycine 10 µM -0.396494425990301 0.36062226707397 no 2190 0.345870159536293 697 5283389 SGTC_2794 7785382 27.27 µM -0.397437194035597 0.360326466840257 no 2191 0.345522546190933 748 2205081 SGTC_2697 mebhydrolin 72.4 µM -0.400885835017119 0.359245144292367 no 2192 0.344252089636051 709 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_438 sphingosine 6.67 µM -0.4019228605064 0.358920204499647 no 2193 0.343870398975369 710 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3065 9113888 49.47 µM -0.402068210343685 0.358874668979904 no 2194 0.343816913786695 749 16648368 SGTC_866 0495-0101 262 µM -0.403875973766217 0.358308496608959 no 2195 0.3431519625024 709 635694 SGTC_59 0330-0160 1.33 µM -0.404971700451115 0.357965478086048 no 2196 0.342749156458175 735 4293482 SGTC_576 1073-0113 22.7 µM -0.405026384971663 0.357948362034049 no 2197 0.342729058262661 762 5439563 SGTC_1893 st059353 36.1 µM -0.405156375539329 0.357907676615003 no 2198 0.342681284631189 772 3112488 SGTC_2030 5175110 200 µM -0.406892150497671 0.357364555632293 no 2199 0.342043600693325 761 2831986 SGTC_575 k072-0246 11.9 µM -0.408102480663488 0.356986016240488 no 2200 0.34159921944985 736 6796779 SGTC_2973 9094665 17.96 µM -0.40933898590966 0.356599435750187 no 2201 0.341145454458177 752 25237061 YIL048W NEO1 SGTC_335 4077-0256 27.6 µM -0.411040690995069 0.356067656226796 no 2202 0.340521348890234 740 3121989 SGTC_3348 9149464 3.537 µM -0.412865889604852 0.355497596277961 no 2203 0.339852436776278 711 1951442 SGTC_2398 5228213 48.84 µM -0.414290728773661 0.355052804133559 no 2204 0.339330601429709 730 80771 YMR134W ERG29 SGTC_1692 fluoroquinolonic acid 71 µM -0.414716898013618 0.354919805184612 no 2205 0.339174580322746 744 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3040 9091894 49.47 µM -0.415752683097643 0.354596630969834 no 2206 0.338795493062157 704 25236966 SGTC_272 doxorubicin 8.13 µM -0.415902850752345 0.354549785997211 no 2207 0.338740546700427 705 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2764 methyldopa 94.69 µM -0.416101320043123 0.35448787664886 no 2208 0.338667932029546 755 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2117 5521686 200 µM -0.421717625285631 0.352737558402335 no 2209 0.336615568998146 721 803312 SGTC_1995 st072814 61.1 µM -0.422266382129844 0.352566704986611 no 2210 0.336415296632653 712 5769371 SGTC_235 0330-0087 5 mM -0.422554553182066 0.352476995900781 no 2211 0.336310145318757 722 46494818 YHR062C RPP1 SGTC_1230 0170-0365 3.77 µM -0.423346870256489 0.352230385950597 no 2212 0.336021101166842 714 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_564 3555-0129 330 µM -0.423487574812519 0.35218659792635 no 2213 0.335969781053991 716 563260 SGTC_2598 perillyl alcohol 100 µM -0.42416082712619 0.351977105268896 no 2214 0.335724263574835 719 10819 An apoptosis inducer. SGTC_1856 st057054 55.7 µM -0.425922135573237 0.351429260091739 no 2215 0.33508229235222 762 1266018 SGTC_1610 st001799 48.1 µM -0.426288699013793 0.351315281322425 no 2216 0.334948745795888 704 621897 SGTC_1169 aniline yellow 25.8 µM -0.426716442160249 0.351182296317676 no 2217 0.334792936604025 734 6051 A DNA damaging agent. SGTC_2093 5331342 194.4 µM -0.427138189400945 0.351051193274209 no 2218 0.334639339314667 729 33839 SGTC_3062 9077494 49.47 µM -0.428302207785588 0.350689442141902 no 2219 0.334215555879319 690 16459633 SGTC_2136 5328288 199.296 µM -0.430228333887487 0.350091142193848 no 2220 0.333514776532722 720 262395 SGTC_177 1327-0068 8.361 µM -0.431497491529693 0.34969711522573 no 2221 0.333053338083968 710 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_823 0417-1665 178 µM -0.431794681380482 0.349604872032302 no 2222 0.332945322722302 766 3429856 SGTC_948 3448-0295 75.3 µM -0.431811847669132 0.349599544149526 no 2223 0.33293908395924 729 678569 SGTC_1700 st030840 7.9285 µM -0.435034069712522 0.348599992228047 no 2224 0.331768848960762 728 5499307 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.437199891770983 0.347928731377449 no 2225 0.330983194113692 708 6708784 An antioxidant flavonoid SGTC_3084 9116877 49.47 µM -0.437934707343025 0.347701095509052 no 2226 0.330716807570695 753 27241325 SGTC_1734 st037168 69.4 µM -0.438568912019748 0.347504671659168 no 2227 0.330486963559831 737 708907 SGTC_1063 disulfiram 1.84 µM -0.438919803323359 0.347396012311578 no 2228 0.330359823456258 726 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1015 4130-4525 82 µM -0.439519291308529 0.34721039987033 no 2229 0.330142653450783 729 1363237 SGTC_1628 st004252 77.7 µM -0.439601791037126 0.347184859313258 no 2230 0.330112771646716 697 692968 SGTC_2395 5646831 180.19 µM -0.439992590289723 0.347063883734035 no 2231 0.329971236979528 776 6808628 SGTC_237 nikkomycin 200 µM -0.440209118311969 0.346996862159816 no 2232 0.329892828109716 761 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_138 0850-0259 40.9225 µM -0.440222144748751 0.346992830260173 no 2233 0.329888111230222 732 6813004 SGTC_658 3253-0951 102 µM -0.443996930468211 0.345825202528693 no 2234 0.328522401577636 736 1184878 SGTC_2886 9058944 51.95 µM -0.445597976307142 0.345330404089053 no 2235 0.327943836324223 718 4949929 SGTC_527 4476-4215 268 µM -0.449890271297517 0.344005188833987 no 2236 0.326394781420357 713 4418754 SGTC_3136 9095672 49.47 µM -0.449947109023414 0.343987653398468 no 2237 0.326374289137969 712 17217380 SGTC_1653 st012112 65 µM -0.451444551618731 0.343525787058579 no 2238 0.325834589897563 756 720429 SGTC_339 3091-4833 71.4 µM -0.451621343989143 0.343471273192745 no 2239 0.325770895509464 736 3240077 SGTC_1066 ketoconazole 628 nM -0.453831353206118 0.34279009267889 no 2240 0.324975107606543 765 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1745 st081495 74 µM -0.4542400793195 0.342664168898154 no 2241 0.324828019388761 728 13842402 YBL026W LSM2 SGTC_3306 9127676 59.7925 µM -0.454392457923067 0.342617227288397 no 2242 0.324773189905395 709 41905287 SGTC_1917 st066507 28.5 µM -0.454530375304331 0.342574742684529 no 2243 0.324723567190228 726 3156428 SGTC_3277 9138724 49.47 µM -0.4552132790081 0.342364407736815 no 2244 0.324477904081321 740 15943418 SGTC_62 0180-0423 3.232 µM -0.456140125726335 0.342079016328626 no 2245 0.324144608739498 768 30102 YGL099W LSG1 SGTC_2459 5811157 9.22 µM -0.456930734888625 0.341835645984372 no 2246 0.32386041593797 739 2870684 YBR192W RIM2 SGTC_2212 7123476 200 µM -0.457901502757057 0.34153690792849 no 2247 0.323511603602055 735 1085715 SGTC_2346 9031566 143.75 µM -0.457905522686045 0.341535671066793 no 2248 0.323510159499742 741 4771086 SGTC_3281 9140613 49.47 µM -0.458996018358827 0.341200207542579 no 2249 0.3231185126694 717 16013766 SGTC_778 3456-2434 196 µM -0.460526052583967 0.340729742609066 no 2250 0.322569337934975 740 5539063 SGTC_2980 9014342 25.29 µM -0.460940432569719 0.34060236892609 no 2251 0.322420671174611 763 2996599 SGTC_1501 4491-0275 38.4 µM -0.46302513638038 0.339961840796449 no 2252 0.321673174882632 748 5104718 SGTC_1812 st052057 4.327 µM -0.463307704277573 0.339875056910404 no 2253 0.321571912118507 750 3645418 SGTC_276 colchicine 750 µM -0.465736074794892 0.339129591950431 no 2254 0.320702213510912 777 2833 A microtubule depolymerizer. SGTC_2416 tofa 880 nM -0.466021722202727 0.33904194477815 no 2255 0.320599976055636 749 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_626 0214-0009 33 µM -0.466038428210047 0.33903681902782 no 2256 0.320593997148335 760 3437874 SGTC_79 0052-0007 94.094 µM -0.467691810792969 0.338529674416241 no 2257 0.320002499104386 757 2801472 SGTC_762 1165-0429 115 µM -0.467882806294489 0.33847110891003 no 2258 0.31993419984943 767 5967793 SGTC_2063 5246145 200 µM -0.468459365510225 0.338294340581708 no 2259 0.319728061524537 776 711240 SGTC_898 1000-0849 28.3 µM -0.468767671890981 0.33819983099274 no 2260 0.319617854991324 755 6751807 SGTC_1196 1588-0294 184 µM -0.46898343322954 0.338133696629718 no 2261 0.319540738881481 767 6144269 SGTC_905 2-aminofluorene 215 µM -0.47097090998054 0.337524737776138 no 2262 0.318830754326325 726 1539 An established DNA mutagen. YPR165W RHO1 SGTC_364 0083-0097 67.7 µM -0.471645977314856 0.337317995177306 no 2263 0.318589751642908 756 5207356 SGTC_2 0422-0095 29 µM -0.47637231454893 0.335871910342132 no 2264 0.316904577439359 722 6790840 SGTC_2704 st078022 71.1 µM -0.478237656642565 0.335301851068012 no 2265 0.316240531672105 777 54697681 SGTC_2349 9023730 187.07 µM -0.479129320332315 0.33502948732933 no 2266 0.315923316115449 765 4126287 SGTC_645 0845-0943 5.41 µM -0.480698458803525 0.334550395744743 no 2267 0.315365413334 745 1885106 SGTC_1219 1469-0211 33.1 µM -0.481452227321756 0.334320349766539 no 2268 0.315097562557423 773 6822282 SGTC_2922 7999257 32.47 µM -0.481592383186358 0.334277581829228 no 2269 0.315047769044007 761 2988377 SGTC_1280 0880-0253 10.1 µM -0.482232921877227 0.334082151691924 no 2270 0.314820246101808 769 6836607 SGTC_2848 9016370 25.97 µM -0.482447847074662 0.334016587491527 no 2271 0.314743919204946 742 7894410 SGTC_205 1486-1330 71.903 µM -0.482732796547797 0.333929669782757 no 2272 0.314642736622466 752 4118834 SGTC_3314 9135860 59.4275 µM -0.483821138049729 0.333597776636056 no 2273 0.314256406063246 768 25252478 SGTC_523 1934-0222 13.7 µM -0.48418934453376 0.333485520376049 no 2274 0.31412574916312 776 1361595 SGTC_890 0929-0006 47.2 µM -0.484465880365312 0.333401221836674 no 2275 0.314027636617098 751 1378169 SGTC_1163 k060-0048 49.9 µM -0.485041186426738 0.333225873837304 no 2276 0.31382356507231 729 6809982 SGTC_878 0828-0289 13.7 µM -0.485459477935455 0.333098405311025 no 2277 0.313675225196736 749 745350 YLR208W SEC13 SGTC_800 3448-7362 155 µM -0.486007854512318 0.332931324374541 no 2278 0.313480798522654 764 15991913 SGTC_1127 asiatic acid 681.4 nM -0.486261258202706 0.332854127818403 no 2279 0.313390971855524 748 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_86 0417-1630 471.922 µM -0.48656296803711 0.332762224583369 no 2280 0.313284036036288 760 3634867 SGTC_2594 a-mangostin 100 µM -0.48658552625874 0.332755353571812 no 2281 0.313276041296389 781 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3278 9139605 49.47 µM -0.486687896250146 0.332724173389155 no 2282 0.313239761992457 767 7958859 SGTC_727 3032-0951 202 µM -0.487252365296178 0.332552266366947 no 2283 0.313039750055348 758 3652836 SGTC_624 k048-0052 28 µM -0.489532146078508 0.33185832588844 no 2284 0.312232500891843 733 6835531 SGTC_407 eburnamonine 100 µM -0.490948889527968 0.331427374839807 no 2285 0.311731298651979 762 3195 SGTC_193 1273-0060 1.558 µM -0.49213446851644 0.33106691180905 no 2286 0.311312143415799 769 2847393 YHR072W ERG7 SGTC_1540 guanosine 70.6 µM -0.494136524077913 0.330458562965313 no 2287 0.310604882429407 757 6802 Guanosine is a purine nucleoside SGTC_1256 0570-0116 285 µM -0.49514424295927 0.330152524665493 no 2288 0.310249152647687 768 410638 SGTC_2761 levamisole 97.89 µM -0.496668464278456 0.329689843526296 no 2289 0.309711432213371 778 26879 An alkaline phosphatase inhibitor. SGTC_1485 3909-9022 254 µM -0.497896049332879 0.329317396415317 no 2290 0.309278656008678 762 714516 SGTC_2900 5328528 85.29 µM -0.498843904078696 0.329029934784096 no 2291 0.308944677585167 752 795359 SGTC_1729 st035615 45.989 µM -0.501257187538995 0.328298500346384 no 2292 0.308095065783278 765 17385451 SGTC_1036 k216-0215 33.5 µM -0.503623434772788 0.327581960454416 no 2293 0.307263010659845 747 622330 SGTC_325 2810-4341 181 µM -0.505222851528239 0.327097989101066 no 2294 0.306701160976038 735 774970 SGTC_1077 5-fluorocytosine 377 nM -0.505384391943775 0.327049124343678 no 2295 0.306644439610712 784 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_829 1635-0120 117 µM -0.505466815861872 0.327024192872366 no 2296 0.306615500048055 772 285054 SGTC_639 0833-0042 114 µM -0.506370542297881 0.326750885620731 no 2297 0.306298275052867 769 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2283 7944793 200 µM -0.507161739986747 0.326511685888574 no 2298 0.306020668913084 746 2970533 SGTC_492 tmb-8 126 µM -0.507193648366882 0.32650204064703 no 2299 0.3060094756114 754 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1427 4048-4900 550 nM -0.507554044611732 0.32639310839159 no 2300 0.305883062973637 768 24132586 SGTC_2566 crystal violet carbinol 226 nM -0.508512822233616 0.326103383334879 no 2301 0.305546874607556 789 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.508634940030112 0.326066489101282 no 2302 0.305504066654945 740 6708630 An antioxidant. SGTC_1663 st014140 55.4 µM -0.510121285881676 0.325617570796764 no 2303 0.304983246752244 746 4207120 SGTC_1193 1488-0126 41.5 µM -0.511467716087727 0.325211129146622 no 2304 0.304511794430233 733 1384710 SGTC_3119 9125183 49.47 µM -0.511686172447094 0.325145204160529 no 2305 0.304435332555534 745 22695334 SGTC_20 0481-0013 4.944 µM -0.512832374699711 0.324799397038569 no 2306 0.304034290614821 769 182045 SGTC_2879 9041815 71.43 µM -0.516425257364713 0.323716410072418 no 2307 0.302778714512061 766 4942971 SGTC_2694 st077685 81.9 µM -0.516732659455604 0.323623820316412 no 2308 0.302671397070416 734 2838096 SGTC_3307 9126885 69.2785 µM -0.516777647114794 0.323610270913072 no 2309 0.302655692814792 757 24824909 SGTC_473 2-arachidonoylglycerol 10 µM -0.517085423771574 0.323517580874665 no 2310 0.302548264182941 756 5282280 An endocannabinoid. SGTC_1763 st044482 94.5 µM -0.517897304413284 0.323273127396246 no 2311 0.302264961429171 780 88505 SGTC_1155 4088-0394 48.2 µM -0.519553434072058 0.322774711071801 no 2312 0.301687430494693 762 2326248 SGTC_1967 st070177 51.4 µM -0.520132473377917 0.32260052278641 no 2313 0.301485623156819 792 5729214 SGTC_2551 apiole 73.87 µM -0.520329343294256 0.322541308672025 no 2314 0.301417023704288 742 10659 A possible DNA adduct former. SGTC_873 0591-4978 488 µM -0.523063465983176 0.321719410949626 no 2315 0.300465044145873 797 3305145 SGTC_2581 avocatin a 64 µM -0.523453604526971 0.321602203359628 no 2316 0.300329314687019 802 6710728 A skin care supplement. SGTC_989 1501-0895 10.3 µM -0.524594981450725 0.321259406549618 no 2317 0.299932388102475 783 2830112 SGTC_2009 4012297 12.05 µM -0.524802297445107 0.321197158378458 no 2318 0.299860317134018 775 45595307 SGTC_637 1181-0519 7.26 µM -0.525895304526344 0.320869057951082 no 2319 0.299480475764746 770 6252091 YGR060W ERG25 SGTC_2418 pentamidine 31.67 µM -0.526810393872791 0.320594472662661 no 2320 0.299162632148968 775 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2563 tomatine 8.54 µM -0.526852248276796 0.32058191601269 no 2321 0.299148098263225 819 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_89 0302-0250 142.109 µM -0.527516905806568 0.320382541061491 no 2322 0.298917339793122 785 4203518 YLR208W SEC13 SGTC_2430 5571206 200 µM -0.527554449224098 0.32037128084231 no 2323 0.298904307731689 778 1731771 SGTC_1125 tnp00248 1.32998 µM -0.527776006464353 0.320304833597826 no 2324 0.298827406096041 753 24207736 SGTC_1531 st059297 52.4 µM -0.528087908913355 0.320211300681021 no 2325 0.298719161238175 758 7566702 SGTC_1488 4013-0813 75.9 µM -0.529501757175085 0.319787460947925 no 2326 0.298228712900115 758 2910057 SGTC_2402 5553605 200 µM -0.530450998485814 0.319503031793198 no 2327 0.297899637466987 762 6758546 SGTC_3289 9119912 71.43 µM -0.530779705969177 0.319404563142243 no 2328 0.297785722372636 796 17014829 SGTC_1329 1447-1697 50.6 µM -0.530811699840351 0.319394979637197 no 2329 0.29777463581017 760 2840515 SGTC_1870 st057514 26.5 µM -0.531395492443703 0.31922013048087 no 2330 0.297572372223722 754 5393161 SGTC_309 k408-0051 1.48 µM -0.531764569074818 0.319109610701465 no 2331 0.297444532529127 776 3640463 SGTC_914 3820-6779 408 µM -0.53244714752061 0.318905255354176 no 2332 0.297208169096321 746 2893481 SGTC_356 1634-0012 32.5 µM -0.532833899324252 0.318789491183449 no 2333 0.297074282699995 798 735457 SGTC_374 0880-0231 82.3 µM -0.533113776297269 0.318705728260413 no 2334 0.296977411618953 771 6833587 SGTC_1310 1188-0297 994 nM -0.535187702175999 0.318085322615506 no 2335 0.296260034634688 766 1588352 SGTC_2104 5389443 200 µM -0.539992183796879 0.316650045242131 no 2336 0.294601211388925 786 2244536 SGTC_1084 voriconazole 435 nM -0.54049594166293 0.316499713306654 no 2337 0.294427529506535 796 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1025 k007-0731 70 µM -0.54076052643455 0.316420767789067 no 2338 0.294336326877977 769 6256118 SGTC_449 xestospongin c 11.1929 µM -0.542413804581557 0.315927660241896 no 2339 0.293766735963616 788 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2439 5492030 7.2 µM -0.544914856939574 0.315182317503297 no 2340 0.292906038817038 769 5722370 SGTC_709 3807-1509 243 µM -0.547505250188657 0.314411142520283 no 2341 0.292015832247763 809 1886677 YPL242C IQG1 SGTC_100 0086-0128 49.5915 µM -0.548491912748482 0.314117620012448 no 2342 0.291677090398032 816 93297 SGTC_3151 9099821 49.47 µM -0.55381023713043 0.312537498273598 no 2343 0.289854360756572 796 17174189 SGTC_1 0258-0098 57.368 µM -0.555159922548597 0.312137040793377 no 2344 0.289392639493166 756 6790032 YDR047W HEM12 SGTC_3161 9100388 49.47 µM -0.555575115679529 0.312013895805851 no 2345 0.289250673334648 796 25236368 SGTC_2130 NSC 7 2.4545 µM -0.556636755924148 0.311699112174528 no 2346 0.288887817748742 777 21448 SGTC_539 4859-0462 2.54 µM -0.557567141477264 0.311423359531874 no 2347 0.288569999642945 768 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_706 4262-0057 46.9 µM -0.558077492527963 0.311272143866795 no 2348 0.288395734593258 786 883298 SGTC_2408 sulbentine 18.36 µM -0.558162264772097 0.311247029158533 no 2349 0.288366792971838 778 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_784 4579-0127 173 µM -0.559931694361359 0.310723016924823 no 2350 0.28776301464495 794 1948547 SGTC_993 3909-8757 62.7 µM -0.559949094328701 0.310717865870723 no 2351 0.287757080261295 778 4288324 YLR208W SEC13 SGTC_569 4130-2812 160 µM -0.562456885730063 0.309975852384359 no 2352 0.286902385317604 796 743552 SGTC_985 1493-0307 8.71 µM -0.5630199179526 0.309809366768931 no 2353 0.286710660507449 787 3278274 SGTC_1241 0364-0022 50.8 µM -0.563028328951883 0.309806879977042 no 2354 0.286707796838441 792 4563895 SGTC_426 0988-0037 14.6 µM -0.563435252869271 0.309686579451215 no 2355 0.286569268810945 791 5383008 SGTC_3318 9139014 38.6185 µM -0.564949315039761 0.309239150360091 no 2356 0.286054119680754 798 16643984 SGTC_38 0929-0051 58.268 µM -0.568589415272028 0.3081646016875 no 2357 0.284817404826354 787 1379719 SGTC_1387 3342-1166 1.8 µM -0.569121894219335 0.308007552664917 no 2358 0.284636710564488 764 3418228 SGTC_2037 5169046 200 µM -0.570154518680073 0.307703091229641 no 2359 0.284286450312836 780 5718022 SGTC_3181 9108277 49.47 µM -0.570222959273542 0.307682916718929 no 2360 0.284263242940808 803 17097298 SGTC_2282 7944268 200 µM -0.572216443795552 0.307095544576588 no 2361 0.283587674288489 809 2970414 SGTC_1938 st074717 56.4 µM -0.572750764002659 0.306938193290458 no 2362 0.283406730211166 774 17250979 SGTC_109 0132-0036 33.701 µM -0.574894033687776 0.306307382088478 no 2363 0.28268148262267 736 67274 A color developer. SGTC_3239 9133757 49.47 µM -0.575583244344587 0.306104654111519 no 2364 0.282448454609448 811 17036923 SGTC_1153 4055-0057 267 µM -0.576436324132188 0.305853807044365 no 2365 0.28216014904899 792 882706 SGTC_2985 9022375 71.43 µM -0.5768272810214 0.305738877067868 no 2366 0.282028069202045 804 4939335 SGTC_1884 5633444 25 µM -0.577728585967121 0.305473992485146 no 2367 0.281723688206709 775 5724239 SGTC_2645 abamectin 100 µM -0.578179957130629 0.305341377223856 no 2368 0.281571314534905 786 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_577 r071-0003 38.6 µM -0.57880147631188 0.305158813369252 no 2369 0.281361567444248 811 4568517 YMR134W ERG29 SGTC_2057 5236571 38.335 µM -0.579326778155439 0.305004550002841 no 2370 0.2811843501085 778 54684039 YBR257W POP4 SGTC_2919 7978188 46.38 µM -0.582129245827092 0.304182146105519 no 2371 0.280239813583641 760 2980291 SGTC_1568 digitonin 820 nM -0.583351250842691 0.303823849692041 no 2372 0.279828433908721 821 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1983 st071813 46.9 µM -0.584066763827428 0.303614146057562 no 2373 0.279587697379259 794 11838595 SGTC_2861 9024595 19.48 µM -0.584811966612166 0.303395809616675 no 2374 0.279337078558766 757 16482810 SGTC_2048 5246248 200 µM -0.585687947470464 0.30313924634456 no 2375 0.279042617451986 781 677046 SGTC_2827 7993847 71.43 µM -0.585976139300067 0.303054859966462 no 2376 0.278945774733229 777 2985692 SGTC_2888 9058547 12.99 µM -0.586563509586762 0.30288290272775 no 2377 0.278748448032028 770 16476514 SGTC_974 1326-0144 138 µM -0.592998850255794 0.301001774952259 no 2378 0.276590960853905 798 5411856 SGTC_1723 st034307 2.5525 µM -0.594038203059247 0.300698454239597 no 2379 0.276243280751533 808 867466 SGTC_7 0192-1582 4.227 µM -0.594121053669394 0.300674281374615 no 2380 0.27621557513176 818 252616 SGTC_2553 4-methylesculetin 85.09 µM -0.596347946396416 0.300024882080533 no 2381 0.275471403441132 795 5319502 SGTC_777 1315-0167 517 µM -0.596426867026208 0.300001879147385 no 2382 0.275445048252743 794 4221767 SGTC_1071 trifluoperazine 6.31 µM -0.59729050474012 0.299750207514668 no 2383 0.275156721420868 822 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2066 5222451 176 µM -0.59800255911021 0.299542780546928 no 2384 0.27491911276063 800 2281147 SGTC_3015 9080845 49.47 µM -0.598581145518346 0.299374281756098 no 2385 0.274726116118805 798 5296973 SGTC_2485 5633444 17.78 µM -0.598947736151081 0.299267543672448 no 2386 0.27460386860163 782 5724239 SGTC_2996 9066192 71.4286 µM -0.599706991617385 0.29904653055888 no 2387 0.274350763933711 788 6472854 SGTC_3301 9125354 19.7965 µM -0.600150933368854 0.298917337056941 no 2388 0.274202825315641 772 41905162 SGTC_1678 st019265 80.2 µM -0.601202413169852 0.298611442341374 no 2389 0.273852588693366 798 5367020 SGTC_2818 7996756 12.99 µM -0.603498147694371 0.297944066380484 no 2390 0.273088673696562 823 2241621 SGTC_1156 4092-0367 4.88 µM -0.60453025031218 0.297644253200521 no 2391 0.272745581831572 816 1357585 SGTC_459 nigericin 15.3 µM -0.60702704681672 0.296919534399942 no 2392 0.271916481472825 827 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2780 5215298 71.43 µM -0.607692727076705 0.296726450820577 no 2393 0.271695643803395 812 2834131 SGTC_2344 7990960 76.95 µM -0.607805834461174 0.296693649225422 no 2394 0.271658129602763 814 140813 SGTC_41 0478-0632 82.643 µM -0.60795509076496 0.296650366840123 no 2395 0.271608629877189 827 3750424 SGTC_1970 st070122 35.8 µM -0.60797121258503 0.296645691895208 no 2396 0.271603283466117 820 102928 SGTC_401 neomycin 50 µM -0.60845206623931 0.296506271270756 no 2397 0.27144384409488 768 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1774 st048371 48.465 µM -0.610989408911389 0.295771081778859 no 2398 0.270603295952368 811 4242727 SGTC_232 clozapine 119 µM -0.611365056045535 0.295662310055184 no 2399 0.270478965508866 793 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1261 0712-0010 12.7 µM -0.614953450607609 0.294624188773904 no 2400 0.269292731130066 805 2840123 SGTC_1417 3966-0327 90.4 µM -0.61621014432629 0.294261025691385 no 2401 0.268877917029434 808 651118 SGTC_141 0443-0274 32.331 µM -0.618200112550288 0.293686382102425 no 2402 0.268221717942477 777 1627241 SGTC_420 mitomycin C 81.9 mM -0.618834122151458 0.293503408164357 no 2403 0.268012820412958 797 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1841 st054148 70 µM -0.620278507395294 0.293086758665867 no 2404 0.267537221217643 819 675442 SGTC_2539 epi(13)torulosol 80 µM -0.621541528653688 0.292722650672567 no 2405 0.267121689580148 804 6708597 SGTC_2056 5235370 200 µM -0.622855470252607 0.292344086292488 no 2406 0.266689751308152 794 5511916 SGTC_3224 9130643 49.47 µM -0.62369101363813 0.292103473401874 no 2407 0.266415262920547 814 17644395 SGTC_1950 st077106 7.18 µM -0.62474098375266 0.291801242423677 no 2408 0.266070534950759 783 13831864 SGTC_2805 7950783 58.44 µM -0.625199584872121 0.291669281097307 no 2409 0.265920037169024 804 1178958 YDL195W SEC31 SGTC_1761 st044296 37 µM -0.626145754600192 0.291397111057058 no 2410 0.265609671782751 816 1826700 SGTC_1597 7-benzyloxygramine 47.5 µM -0.628906980321993 0.29060351014485 no 2411 0.264704977963206 815 260807 SGTC_926 2268-1401 59.4 µM -0.628995778232715 0.290578005623484 no 2412 0.264675910057475 813 2931578 SGTC_894 0960-0238 55.9 µM -0.630155897213134 0.290244892704157 no 2413 0.264296295500807 821 6741907 YDL195W SEC31 SGTC_975 1335-0046 28.5 µM -0.632296358348509 0.289630757359078 no 2414 0.263596621363596 827 16486740 SGTC_2936 9038235 15.59 µM -0.633865373426931 0.289180967593528 no 2415 0.263084342528368 804 4749415 SGTC_225 nsc-122657 1.016 µM -0.634621490196991 0.288964328823427 no 2416 0.262837654397899 812 275685 SGTC_2096 5468907 200 µM -0.635118373284799 0.288822005973134 no 2417 0.262675607415472 802 759785 SGTC_794 k038-0031 316 µM -0.63599895564071 0.288569860745402 no 2418 0.262388551364504 818 6624242 SGTC_519 k048-0011 62.8 µM -0.636200774423129 0.288512086732708 no 2419 0.26232278423745 796 6836379 SGTC_188 3229-0966 278.469 µM -0.636869859794333 0.288320588818509 no 2420 0.262104808335995 812 5722370 SGTC_1330 1469-0054 61.8 µM -0.637579384098003 0.288117582440308 no 2421 0.261873759616408 811 7102664 SGTC_1514 1189-1591 158 µM -0.637581435660448 0.288116995552917 no 2422 0.261873091699332 839 767698 YMR146C TIF34 SGTC_452 diindolylmethane 8 µM -0.638212231090502 0.287936571607713 no 2423 0.261667768179166 796 3071 Inhibits expression of several cancer promoting factors. SGTC_623 k072-0108 16.9 µM -0.638648449524499 0.287811832967659 no 2424 0.261525827683427 802 5382803 SGTC_1658 st012944 20 µM -0.638697481963389 0.287797813515308 no 2425 0.261509875559445 808 24207260 SGTC_3299 9121982 43.1275 µM -0.639219566890894 0.287648557963037 no 2426 0.261340052387084 817 17594604 YPL160W CDC60 SGTC_2832 7992762 51.95 µM -0.639311107430698 0.287622391788076 no 2427 0.261310282025732 799 2985177 SGTC_1964 st076914 61 µM -0.63988397475506 0.28745866752699 no 2428 0.261124016521924 835 24208661 SGTC_254 nsc-64875 3.808 µM -0.641311684588495 0.287050823012102 no 2429 0.260660099570872 808 56993 SGTC_2994 9053520 71.4286 µM -0.644133353381647 0.28624558234203 no 2430 0.259744481876424 808 4647384 SGTC_295 k015-0027 31 µM -0.648369307198707 0.285038754419313 no 2431 0.258373058494165 815 3887424 SGTC_2176 5809774 33.9695 µM -0.64886945653663 0.284896421605961 no 2432 0.258211379211041 797 2870539 SGTC_1989 st071868 50.2 µM -0.650423466472392 0.284454396938141 no 2433 0.257709361665307 818 16414057 SGTC_81 0411-0046 9.971 µM -0.652340961452387 0.283909434067257 no 2434 0.257090620584137 819 12925265 SGTC_1321 1326-2144 215 µM -0.653588408040853 0.283555171208799 no 2435 0.256688507239106 831 3513030 SGTC_2038 4100038 30.985 µM -0.654136795878795 0.283399501379341 no 2436 0.256511838565368 804 3596803 SGTC_257 daunorubicin 18.5 µM -0.65426425911533 0.283363324498043 no 2437 0.256470784072301 812 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2006 4011487 200 µM -0.655315640378514 0.283065003767333 no 2438 0.256132276463957 821 45595294 SGTC_2863 9028737 58.44 µM -0.658744062436482 0.282093265944033 no 2439 0.255030066536295 826 6460917 SGTC_2271 7849410 118.62 µM -0.659910256588476 0.281763091163045 no 2440 0.254655710936485 832 972430 SGTC_1886 st057356 49.9 µM -0.660934025573425 0.281473393652175 no 2441 0.254327312072126 812 24207747 SGTC_1421 4029-0249 71.4 µM -0.661562953646172 0.281295496179284 no 2442 0.254125678192975 831 2894095 SGTC_2407 paclitaxel 400 µM -0.664466203553842 0.280474992426184 no 2443 0.253195986376976 852 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1965 Pectolinarigenin 58.4 µM -0.66517479726962 0.280274908801231 no 2444 0.252969349147723 827 5320438 An anti-inflammatory. SGTC_384 k007-0144 5.16 µM -0.666684166452262 0.279848943069448 no 2445 0.252486947307927 831 6824886 SGTC_1627 st003713 25.6 µM -0.666984817820891 0.279764132439422 no 2446 0.252390915574396 822 16195070 YER133W GLC7 SGTC_2357 9067248 200 µM -0.667423750089613 0.279640336599969 no 2447 0.252250749803513 837 9150235 SGTC_932 2857-0803 154 µM -0.667500745704245 0.279618623606555 no 2448 0.252226166757771 827 674898 SGTC_855 0428-0020 25 µM -0.667912004805646 0.279502661172342 no 2449 0.252094881959762 810 6812414 SGTC_1294 1000-1494 117 µM -0.66862346001054 0.279302107817946 no 2450 0.251867851763709 816 712797 YDL207W GLE1 SGTC_2025 5147754 141 µM -0.669975054575423 0.278921297166636 no 2451 0.251436846195002 805 315777 YLR208W SEC13 SGTC_557 1315-0110 16.2 µM -0.669984950807141 0.27891850984331 no 2452 0.251433691856161 810 6833801 SGTC_816 0325-0417 81.3 µM -0.670520362406659 0.278767728682406 no 2453 0.251263065187708 826 68101 SGTC_1030 k029-0042 36.7 µM -0.670791420555297 0.278691409152875 no 2454 0.251176706866051 824 6080581 SGTC_2046 4110841 106 µM -0.670961901543687 0.278643413487612 no 2455 0.251122400171671 817 44119630 YMR134W ERG29 SGTC_540 1187-0821 17.3 µM -0.671485427376493 0.278496049954291 no 2456 0.250955669922491 830 847520 SGTC_963 1269-2853 151 µM -0.671834824717815 0.278397721731552 no 2457 0.250844427969035 806 3668223 SGTC_2502 avocadyne acetate 18.59 µM -0.673826200704335 0.277837627233697 no 2458 0.250210907660933 804 3952079 SGTC_2536 dehydroabietamide 32.04 µM -0.67464082605501 0.277608664328957 no 2459 0.249951994077439 822 3983547 SGTC_2587 piperic acid 92.2 µM -0.676531013729354 0.27707775357052 no 2460 0.249351781060756 812 5370536 SGTC_2814 7977482 42.97 µM -0.676670722021513 0.277038532416222 no 2461 0.249307448309028 825 6456762 SGTC_361 000s-0510 1.45 µM -0.676752604346348 0.277015546358796 no 2462 0.249281467054906 824 660 SGTC_2267 7931562 200 µM -0.676935011308047 0.276964344318919 no 2463 0.249223594518727 814 934880 SGTC_332 4112-0506 40.9 µM -0.678652986677963 0.276482332259765 no 2464 0.248678880558244 840 2790355 SGTC_824 1304-0008 100 µM -0.681594350426167 0.275658030511503 no 2465 0.247747744150946 824 768245 SGTC_1560 lithocholic acid 53.1 µM -0.682881412147318 0.275297718612181 no 2466 0.247340890178747 823 9903 A bile acid which acts as a detergent. SGTC_1715 st032160 10.2275 µM -0.683350662353012 0.275166410079094 no 2467 0.247192644066157 807 5289825 SGTC_635 k038-0028 24.7 µM -0.683472538007139 0.275132311115418 no 2468 0.247154148731534 846 4035102 SGTC_825 1988-2224 89.6 µM -0.68354908310178 0.275110896020213 no 2469 0.247129973031637 828 1180859 SGTC_2492 derrusnin 100 µM -0.685150891727748 0.274662944892634 no 2470 0.246624354437586 846 1715307 Part of coumarin class of compounds. SGTC_1507 4075-3230 155 µM -0.685266163923917 0.274630722518203 no 2471 0.246587989598158 825 659771 SGTC_1286 0929-0070 131 µM -0.685406484002415 0.274591500952305 no 2472 0.246543726797239 830 1420408 SGTC_970 1315-0089 19.5 µM -0.687663590977617 0.273960985668243 no 2473 0.245832326449379 823 6811083 YLR033W RSC58 SGTC_4 0960-0234 25.671 µM -0.68859143441213 0.27370200341293 no 2474 0.245540206437683 815 6821112 SGTC_2463 5473429 200 µM -0.690271229459073 0.273233442638432 no 2475 0.245011818526904 821 5399405 SGTC_1032 k061-1018 98.7 µM -0.69083972091487 0.273074958105911 no 2476 0.244833135343725 839 4005393 SGTC_1654 st012436 41.8 µM -0.692002934972729 0.272750818360342 no 2477 0.24446774292231 836 4323132 SGTC_1785 bathophenanthroline 24 µM -0.692268604071423 0.27267681413575 no 2478 0.244384331350701 820 72812 An iron chelator. SGTC_2229 7354935 190 µM -0.692294571084894 0.272669581353787 no 2479 0.244376179364621 842 318112 SGTC_994 3910-0338 138 µM -0.693341482063347 0.272378056915994 no 2480 0.244047638175349 833 3479481 SGTC_956 1185-0240 191 µM -0.695749117738559 0.27170821098701 no 2481 0.243292979733275 833 1416193 SGTC_1096 rimcazole 32.2 µM -0.69628751069176 0.271558533008383 no 2482 0.243124396532083 839 18528119 A dopamine reuptake inhibitor. SGTC_585 0kpi-0023 191 µM -0.697647533803333 0.27118061758481 no 2483 0.242698823515123 810 64601 SGTC_3109 9122853 49.47 µM -0.698219990332653 0.271021625099678 no 2484 0.242519813367851 873 1234709 SGTC_3141 9094609 49.47 µM -0.698507045046532 0.270941916829718 no 2485 0.242430076786759 853 25236309 YDL196W YDL196W SGTC_2890 9046729 58.44 µM -0.699945657242372 0.270542624707934 no 2486 0.241980621285633 845 903329 SGTC_1616 st002734 56.1 µM -0.70020007931104 0.270472039528555 no 2487 0.241901181046451 829 4026101 SGTC_741 4582-0002 126 µM -0.700347145051035 0.270431242777729 no 2488 0.241855267986917 840 2912688 SGTC_3257 9139206 32.98 µM -0.701511429692602 0.270108373144606 no 2489 0.241491952109737 833 4910041 SGTC_2075 5212009 200 µM -0.702739181034088 0.269768112474974 no 2490 0.241109152721944 842 780898 SGTC_2387 9077560 195.08 µM -0.705678693526866 0.268954325142733 no 2491 0.240193986969177 826 5303272 SGTC_71 0417-1750 47.813 µM -0.706404365869371 0.268753616721248 no 2492 0.239968353305019 816 6811472 SGTC_1140 3229-1848 2.98 µM -0.707773804798591 0.268375058674585 no 2493 0.239542868032752 842 2849525 SGTC_728 3030-5151 22.5 µM -0.708045153567409 0.268300080778369 no 2494 0.239458608769467 835 3125388 SGTC_2591 skatole 100 µM -0.712052524724154 0.267194009983986 no 2495 0.238216125625728 852 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_531 3788-1495 174 µM -0.71475668943707 0.266448938688774 no 2496 0.237379700840514 827 2896655 SGTC_2864 9034755 47.6 µM -0.714852533288265 0.266422550386605 no 2497 0.237350085011939 828 4930451 SGTC_2974 9094440 9.66 µM -0.715369044902788 0.266280364086409 no 2498 0.237190517434371 840 25236134 SGTC_2659 sanguinarine 24.21 µM -0.716766580567594 0.265895840451872 no 2499 0.236759067880012 839 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1464 k208-0027 110 µM -0.716787923421424 0.2658899702745 no 2500 0.236752482226184 831 X1464 SGTC_1416 3966-0321 25.3 µM -0.718256957338493 0.265486082394805 no 2501 0.236299432241258 841 582530 YLR208W SEC13 SGTC_2135 5326629 150.42 µM -0.722411493576604 0.264345545044961 no 2502 0.235020761277046 852 5020077 SGTC_1206 3978-0017 132 µM -0.722993340605832 0.264186010995175 no 2503 0.234841987776409 838 3873677 SGTC_842 0271-0008 11.1 µM -0.724284110770123 0.263832275607735 no 2504 0.234445664878856 827 1221709 SGTC_604 1000-0114 314 µM -0.72508558272449 0.263612753920927 no 2505 0.234199764283454 854 1572745 SGTC_751 0833-0568 350 µM -0.725413252259244 0.26352303268657 no 2506 0.234099272728828 848 6954252 SGTC_1456 k015-0012 13 µM -0.725481578078463 0.26350432593264 no 2507 0.234078321187563 853 2989616 SGTC_1287 0971-0001 34.6 µM -0.72552909705517 0.263491316231304 no 2508 0.234063750502903 830 4665869 SGTC_2693 st077581 40.7 µM -0.729022807972094 0.26253571024181 no 2509 0.23299385547066 845 25238761 SGTC_1603 st002045 67.8 µM -0.730411688968137 0.262156314422001 no 2510 0.232569287776531 857 5887985 SGTC_163 TUB2.036 7.546 µM -0.732217291359828 0.261663504635125 no 2511 0.232017975986112 855 15992207 YJR013W GPI14 SGTC_1237 0330-0133 46.1 µM -0.734573128682535 0.261021232713492 no 2512 0.231299754076803 878 X1237 YHR072W ERG7 SGTC_2435 5706476 10.6 µM -0.734710134929736 0.260983905655924 no 2513 0.231258023303412 818 5725375 SGTC_809 3998-0021 90 µM -0.735677587782973 0.260720403348813 no 2514 0.230963466125957 855 715485 SGTC_1579 chlormadinone acetate 49.4 µM -0.7358175412497 0.260682295970115 no 2515 0.230920872304185 848 45114258 A steroidal progestin. SGTC_1000 4048-0884 8.67 µM -0.735997579125052 0.2606332783815 no 2516 0.230866085533992 852 13040088 SGTC_3078 9116413 49.47 µM -0.736957140781352 0.260372105634612 no 2517 0.230574206756487 852 17177322 SGTC_2409 alverine citrate 63.97 µM -0.737378120505869 0.260257566261861 no 2518 0.230446218555763 837 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1053 3366-3204 134 µM -0.738094269190295 0.260062777542917 no 2519 0.230228582996867 869 3632071 YPR165W RHO1 SGTC_722 3534-0461 190 µM -0.738444608348023 0.259967514500941 no 2520 0.230122157807642 844 658262 SGTC_251 melphalan 456.522 µM -0.739245643495117 0.259749767362633 no 2521 0.229878924713255 859 460612 A DNA alkylator. SGTC_929 2805-0021 398 µM -0.739792248479736 0.259601236576868 no 2522 0.22971303159448 888 3098024 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.740340737266981 0.259452237988151 no 2523 0.229546634163222 837 6312947 SGTC_1575 cyproterone acetate 48 µM -0.741168760478875 0.259227386756381 no 2524 0.229295561135831 867 9880 An androgen receptor antagonist and liver toxin. SGTC_1242 0402-0103 60.1 µM -0.741755651359213 0.259068076467798 no 2525 0.22911769748189 850 432868 SGTC_2928 9011484 9.79 µM -0.743216752337232 0.258671683715987 no 2526 0.228675231284273 839 2994751 SGTC_660 4031-1742 102 µM -0.743645985957671 0.258555293490651 no 2527 0.228545337418025 838 6738706 SGTC_1350 1495-0454 146 µM -0.743880888719474 0.258491609159592 no 2528 0.22847426913914 836 1069057 SGTC_1691 st019933 84.6 µM -0.744029666673034 0.258451278270766 no 2529 0.228429263774871 869 6176082 SGTC_1567 st069303 68.4 µM -0.745423261530571 0.258073659396419 no 2530 0.228007942951757 851 5581319 SGTC_103 0844-0104 51.839 µM -0.747083270729174 0.257624224586497 no 2531 0.227506648894279 864 5375804 SGTC_1201 1889-3372 45.9 µM -0.749881994280664 0.256867412827605 no 2532 0.226662889888674 837 5392199 SGTC_168 3970-0862 530.542 µM -0.75014334112107 0.256796800306043 no 2533 0.226584189320077 854 3135186 SGTC_165 k038-0023 64.381 µM -0.75059064978074 0.256675966766012 no 2534 0.226449525019476 857 46368543 SGTC_2923 7992654 58.14 µM -0.750707620342509 0.256644373855344 no 2535 0.226414317957074 838 2985126 SGTC_685 1278-0033 54.9 µM -0.752438434995461 0.256177129988266 no 2536 0.225893720098675 862 3590572 SGTC_3139 9095020 49.47 µM -0.753136167232589 0.255988898482331 no 2537 0.225684046398759 806 25236292 SGTC_3036 9090181 49.47 µM -0.753559560826619 0.255874712183069 no 2538 0.225556867189261 868 25236586 SGTC_2227 7312221 64.1025 µM -0.756172816151834 0.255170524244699 no 2539 0.224772794417385 879 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_867 0518-0118 155 µM -0.760147502779491 0.254101420668344 no 2540 0.223583210398085 847 6848158 SGTC_1922 5578187 25 µM -0.760257798249639 0.254071787144843 no 2541 0.223550251202841 820 1350412 SGTC_1776 st049249 45.9 µM -0.760433584474794 0.254024561706642 no 2542 0.223497727355158 857 1822314 SGTC_1928 4'-methoxychalcone 40.3 µM -0.760715702595468 0.253948779548847 no 2543 0.22341344686354 849 641818 SGTC_3297 9117502 71.43 µM -0.760764613718918 0.25393564232108 no 2544 0.223398836903119 835 7453720 SGTC_1117 retinoic acid 1.10837 µM -0.764239141955482 0.253003318667945 no 2545 0.22236237239535 856 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3308 9128332 17.569 µM -0.76434031255878 0.252976198469679 no 2546 0.222332233989315 826 17332805 YDL196W YDL196W SGTC_1741 st038134 10.228 µM -0.769184893663954 0.25167933316937 no 2547 0.220891778462744 863 1272587 SGTC_2327 6189656 200 µM -0.770735652127039 0.251264947536115 no 2548 0.22043181758553 875 5349088 SGTC_2220 6782180 200 µM -0.771966254342606 0.250936369304737 no 2549 0.220067207242714 847 833803 SGTC_1119 parthenolide 318.541 nM -0.772102724045822 0.250899945081696 no 2550 0.220026794486793 896 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2111 5486399 200 µM -0.772566710936602 0.250776126353752 no 2551 0.219889425958139 848 689674 SGTC_2647 atorvastatin 60.16 µM -0.772881850951602 0.25069204709561 no 2552 0.219796153292693 845 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_763 3453-1109 128 µM -0.776132566273475 0.249825629242927 no 2553 0.218835358421529 847 1560353 SGTC_1936 st074407 74.3 µM -0.776851877366441 0.249634125247414 no 2554 0.218623082846747 872 809813 SGTC_2858 9025781 8.96 µM -0.777021694511597 0.24958892578308 no 2555 0.218572985486197 843 4894980 YPL153C RAD53 SGTC_2803 7707263 71.43 µM -0.778330846368634 0.249240620733794 no 2556 0.218186997588093 871 2199229 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.780145347880264 0.248758293111722 no 2557 0.217652663398382 860 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2474 5321570 43.32 µM -0.78019873126852 0.248744110362671 no 2558 0.217636954507076 865 2841384 SGTC_2315 7733312 200 µM -0.780342108731258 0.248706020371338 no 2559 0.217594766699702 867 726316 SGTC_1328 1441-0025 69.2 µM -0.781003383587321 0.248530384757146 no 2560 0.217400252325563 871 4562601 SGTC_3258 9138477 49.47 µM -0.78175153354453 0.248331754689592 no 2561 0.21718030468364 880 4970355 SGTC_3332 9141069 11.198 µM -0.783489017085891 0.247870788189778 no 2562 0.216670000352649 865 17332883 SGTC_1134 3477-0009 42.5 µM -0.783588500008552 0.247844408507954 no 2563 0.216640802914481 848 3973534 SGTC_319 1348-1596 45.5 µM -0.784538464967015 0.247592583755522 no 2564 0.216362110482861 863 5380505 SGTC_3073 9114972 49.47 µM -0.785189275729651 0.247420140256778 no 2565 0.216171301139867 829 41905075 SGTC_1012 4112-3522 18 µM -0.785201476630402 0.247416908031462 no 2566 0.216167724923509 855 3112398 SGTC_1005 4092-0690 4.4 µM -0.785602702534818 0.247310629066129 no 2567 0.216050140348213 884 1529343 SGTC_2295 7971645 200 µM -0.785975126422177 0.247212001185444 no 2568 0.215941029748591 884 2978226 YKL099C UTP11 SGTC_3173 9105693 49.47 µM -0.789755735183978 0.246211985705856 no 2569 0.21483521729474 884 17096658 SGTC_1852 st056254 31.4 µM -0.791522295721085 0.245745454326206 no 2570 0.214319635414494 857 442583 SGTC_2670 beta-carotene 100 µM -0.791880158208383 0.245651004184431 no 2571 0.214215278713568 818 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1400 3771-8998 51.5 µM -0.792061646412964 0.245603111709935 no 2572 0.214162366024752 852 670767 SGTC_1291 0993-0025 5.79 µM -0.793667011478895 0.245179694350265 no 2573 0.213694654844139 869 4353356 SGTC_72 0744-0168 198.391 µM -0.795339013786982 0.244739118962944 no 2574 0.213208162541602 896 677577 SGTC_580 1123-0028 41 µM -0.79630358306786 0.244485147355584 no 2575 0.212927801741994 894 1677248 YPR107C YTH1 SGTC_1250 0485-0349 40.2 µM -0.797403737287523 0.244195649577558 no 2576 0.212608294730377 881 6842794 YDL195W SEC31 SGTC_2930 9013230 14.89 µM -0.7981663122076 0.243995091905982 no 2577 0.212386991964648 837 2995857 SGTC_2335 9018011 154.17 µM -0.798307408676102 0.243957993192338 no 2578 0.212346059878658 859 6458208 SGTC_2300 7976697 71.57 µM -0.798371549690106 0.243941129502113 no 2579 0.21232745409451 857 2236109 SGTC_1191 1487-1166 10.6 µM -0.8031156449355 0.242695576970821 no 2580 0.210953947930284 902 3955771 SGTC_1885 st057546 99.9 µM -0.803581271221504 0.24257351355231 no 2581 0.210819421533008 863 702008 SGTC_813 k007-0158 173 µM -0.803704333376746 0.24254125849909 no 2582 0.210783875443705 867 6523916 SGTC_2390 9097792 176.6 µM -0.804434512119645 0.242349923695557 no 2583 0.21057303809055 856 4497149 SGTC_748 act1.228 77.9 µM -0.804668009509337 0.242288755697783 no 2584 0.210505642405331 861 4421505 YNR035C ARC35 SGTC_1868 st057644 42.7 µM -0.807400177094129 0.241573647243039 no 2585 0.20971798247336 881 688665 SGTC_2744 captopril 92.04 µM -0.807909214657355 0.241440540212014 no 2586 0.209571423159238 832 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1033 k072-0102 21.3 µM -0.808347459704282 0.241325976469649 no 2587 0.209445294312055 863 5965931 SGTC_3014 9081533 49.47 µM -0.808452271051192 0.241298581609548 no 2588 0.209415135766022 881 21367265 SGTC_1619 st003326 88.7 µM -0.811131633759744 0.240598842526424 no 2589 0.208645040591376 822 2849032 SGTC_381 3461-2219 42.7 µM -0.812812015868282 0.240160560289743 no 2590 0.208162922639929 896 2883159 SGTC_1509 1326-1131 80 µM -0.813072385003616 0.240092688999136 no 2591 0.208088279073987 840 768313 SGTC_1013 4112-3890 241 µM -0.814022218166336 0.239845181495235 no 2592 0.207816111434222 874 705171 SGTC_1298 1079-1278 263 µM -0.814836253981954 0.239633170869274 no 2593 0.207583022905785 876 2840950 SGTC_3217 9129673 49.47 µM -0.815638168119216 0.239424417314884 no 2594 0.207353556384058 878 17248312 SGTC_2246 7293507 91.5585 µM -0.815780546400932 0.239387363915326 no 2595 0.207312830736298 852 887656 SGTC_3011 9081274 71.4286 µM -0.819336912898635 0.238462850127353 no 2596 0.206297108897694 896 6625322 SGTC_1112 tnp00069 1.16933 µM -0.824230746370679 0.237193850419262 no 2597 0.204904230007981 883 145826 SGTC_2523 spermine 47.74 µM -0.826360790206549 0.236642678462344 no 2598 0.204299729389824 834 1103 A DNA binding polyamine. SGTC_725 1497-0963 19 µM -0.827265574073178 0.236408769203252 no 2599 0.204043275846466 867 3549977 SGTC_2958 9077254 16.72 µM -0.827386610363211 0.236377487949559 no 2600 0.204008983655712 886 16457351 SGTC_1572 epiandrosterone 68.9 µM -0.827563454748718 0.236331787456024 no 2601 0.203958886002267 869 441302 A steroid. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.827999391673217 0.236219152509578 no 2602 0.203835422203427 905 689007 SGTC_1600 coumarin 106 71.1 µM -0.828038411356356 0.236209072263661 no 2603 0.203824373423248 883 100336 A hepatotoxic, DNA x-linker. SGTC_1412 3909-8563 178 µM -0.829466713163563 0.235840251500469 no 2604 0.203420182436551 897 23767530 SGTC_2859 9028643 45.46 µM -0.829844396659579 0.235742777934223 no 2605 0.203313382874295 839 17151580 SGTC_3032 9089427 49.47 µM -0.829957682244265 0.23571354521928 no 2606 0.203281355034199 836 17173707 SGTC_764 1951-2361 146 µM -0.83028655790822 0.235628692010185 no 2607 0.203188393122606 870 5438930 SGTC_702 1488-0190 94 µM -0.830405166249468 0.235598094006899 no 2608 0.203154872824924 855 949357 SGTC_3010 9080089 71.4286 µM -0.832401576821854 0.235083398784786 no 2609 0.20259115615571 870 17027233 SGTC_1059 3448-6867 171 µM -0.833384653651056 0.234830179851027 no 2610 0.202313913466001 879 3934407 SGTC_845 0330-0138 4.51 µM -0.83371392772913 0.234745399819618 no 2611 0.202221103899347 878 9039800 SGTC_2221 6807166 181.081 µM -0.833755796554833 0.234734620832578 no 2612 0.202209304529939 852 674925 SGTC_1419 3993-2473 62.6 µM -0.834167877729879 0.234628546534753 no 2613 0.202093194805021 890 704026 SGTC_1525 8-methoxypsoralen 92.5 µM -0.834785828705247 0.234469528744595 no 2614 0.201919153130529 896 4114 Related to psoralen; DNA damaging agent. SGTC_352 k048-0007 5.11 µM -0.835099362192073 0.234388869743064 no 2615 0.201830882886191 909 6811911 SGTC_609 0986-0026 86.3 µM -0.835306223009533 0.234335661548694 no 2616 0.201772657246539 861 2848610 SGTC_2354 9060492 162 µM -0.836726502561482 0.233970521556963 no 2617 0.201373159245771 906 6471895 SGTC_1239 0337-0584 35.4 µM -0.836906704081939 0.233924216049852 no 2618 0.201322505851873 900 914301 YML130C ERO1 SGTC_930 2810-3379 265 µM -0.841110320827815 0.232845475004914 no 2619 0.20014306686387 909 1015764 SGTC_934 2950-0684 338 µM -0.841595055806175 0.232721259261772 no 2620 0.200007328858581 894 1121253 SGTC_1724 st037281 8.293 µM -0.842969798356763 0.232369175072714 no 2621 0.199622667500792 869 574124 YDL195W SEC31 SGTC_1344 1488-0097 29.1 µM -0.843745927812391 0.232170532129626 no 2622 0.199405698487497 887 747966 SGTC_421 streptovitacin 30 mM -0.845188835759439 0.231801484881101 no 2623 0.19900270732741 911 91467 include heat shock SGTC_592 k241-0073 46.5 µM -0.845514947600515 0.231718121755708 no 2624 0.198911695274394 880 4230158 SGTC_2376 9072922 81.32 µM -0.84822316067043 0.231026474023151 no 2625 0.198156850526987 905 17087968 SGTC_1888 azatryptophan 97.5 µM -0.849589477878923 0.230677969500686 no 2626 0.197776681977433 887 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2143 5623677 140.463 µM -0.85049441085421 0.23044731135469 no 2627 0.197525133258498 857 5375313 SGTC_1029 k015-0030 64.7 µM -0.855871968259908 0.229079289794342 no 2628 0.196034300862862 878 2208316 SGTC_1327 1436-0082 2.18 µM -0.856637966503391 0.228884795328063 no 2629 0.195822498190107 902 15992205 SGTC_1900 st060200 72.8 µM -0.856790624537303 0.228846045034408 no 2630 0.195780304017489 894 688945 SGTC_588 3970-1144 52.9 µM -0.857383395689231 0.228695612556951 no 2631 0.195616516362835 859 1888707 SGTC_2891 9063876 19.48 µM -0.858314020048511 0.228459552306495 no 2632 0.195359544917925 870 6472478 SGTC_2772 vinpocetine 57.06 µM -0.858705732575068 0.228360232269808 no 2633 0.195251443474052 899 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3328 9140624 29.0385 µM -0.859279905031945 0.228214692761408 no 2634 0.195093054015039 891 4904392 SGTC_2819 7996655 46.38 µM -0.859424433215098 0.228178066408607 no 2635 0.195053197219488 856 6456960 SGTC_2116 5511452 16.8835 µM -0.859858819014207 0.228068004193395 no 2636 0.194933435669877 900 870744 SGTC_2933 9026794 32.47 µM -0.862279810940209 0.227455134166236 no 2637 0.19426677988837 891 17586027 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.863571037036548 0.227128642143649 no 2638 0.193911790174655 889 23665772 A membrane-active detergent. SGTC_2526 patulin 37.61 µM -0.865211536533627 0.226714216159127 no 2639 0.193461347267904 901 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_839 0122-0028 230 µM -0.866289916271696 0.226442026502903 no 2640 0.193165597343981 886 759448 SGTC_161 4065-0411 162.148 µM -0.866465514843497 0.226397721824343 no 2641 0.19311746488168 902 1906281 YLR208W SEC13 SGTC_904 1141-0088 396 µM -0.868313745458144 0.225931698081596 no 2642 0.192611299689791 910 1378119 SGTC_52 0329-0193 875 nM -0.869375263652204 0.225664286042679 no 2643 0.192320954219834 897 3739292 SGTC_858 0438-0351 2.77 µM -0.870902879448491 0.225279771635264 no 2644 0.191903592225501 889 2799119 SGTC_2318 6029776 164 µM -0.871912980960151 0.225025724074779 no 2645 0.191627925759746 892 818325 SGTC_3039 9090270 49.47 µM -0.871928161307842 0.225021907350368 no 2646 0.19162378474692 854 17173750 SGTC_305 1682-2595 20.8 µM -0.87197541423502 0.225010027000887 no 2647 0.191610895078284 893 226033 SGTC_1681 tripelennamine 100 µM -0.873232217476519 0.224694171523618 no 2648 0.19126825882189 870 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_712 r015-0009 80.6 µM -0.873427796268042 0.224645041953765 no 2649 0.191214972901425 912 6813872 YLR060W FRS1 SGTC_1188 1403-0014 4.57 µM -0.873671889973965 0.224583733942256 no 2650 0.191148481742241 874 9614867 SGTC_2164 5685496 200 µM -0.873804013973747 0.224550552860888 no 2651 0.191112497060662 920 759046 SGTC_466 geldanamycin 89.2 µM -0.873959678609253 0.224511463449585 no 2652 0.191070106290797 872 5288382 HSP90 inhibitor. SGTC_687 k029-0044 34.9 µM -0.874303903887177 0.224425037723128 no 2653 0.190976386948851 873 5829338 SGTC_1208 2323-2347 50.3 µM -0.874868675434791 0.224283279660793 no 2654 0.190822682409568 900 5412760 SGTC_245 methotrexate 289.6 µM -0.877755784306752 0.223559407946689 no 2655 0.190038132088581 876 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1363 1636-0063 10.4 µM -0.877758857012893 0.223558638249534 no 2656 0.190037298161103 877 6072185 SGTC_2109 5483026 200 µM -0.878909325164171 0.223270557814841 no 2657 0.189725221054759 913 759335 SGTC_2411 st077133 39.94 µM -0.880946642020304 0.222760926719342 no 2658 0.189173350368882 922 1403142 YNL221C POP1 SGTC_739 1486-1183 203 µM -0.884170845254423 0.221955754455294 no 2659 0.188301997049505 898 4346692 SGTC_2106 5357045 167.29 µM -0.885654478980749 0.221585809293341 no 2660 0.187901872522877 892 668842 SGTC_1587 estradiol valerate 56.1 µM -0.885784991483343 0.221553282777188 no 2661 0.187866699451594 906 13791 A steroid. SGTC_738 1315-0003 72.4 µM -0.886733953659401 0.221316863115481 no 2662 0.187611076765815 918 6251474 SGTC_2286 7945697 125 µM -0.887000633329568 0.221250449863955 no 2663 0.187539279753142 907 1245733 SGTC_3241 9133421 49.47 µM -0.887933218097481 0.221018290895018 no 2664 0.187288337526902 931 17018221 SGTC_2991 9074669 71.4286 µM -0.888032212173248 0.220993655357925 no 2665 0.187261712148848 884 17333109 SGTC_1275 0867-0008 21.1 µM -0.88905094512703 0.220740226123478 no 2666 0.186987850425106 900 3422836 SGTC_1924 st058459 75.1 µM -0.890083832901272 0.22048344562075 no 2667 0.186710436637306 881 688683 SGTC_1671 st016596 74.5 µM -0.890220257363542 0.220449542694099 no 2668 0.186673814708585 900 2829167 SGTC_2525 harmine 47.85 µM -0.89090150369974 0.22028029046705 no 2669 0.186491006769278 876 5280953 A monoamine oxidase inhibitor SGTC_892 0929-0076 29 µM -0.89272998699969 0.219826381518318 no 2670 0.186000893816306 899 5751038 SGTC_184 1494-0393 24.714 µM -0.893300823324139 0.21968478519766 no 2671 0.185848048603471 899 3090647 SGTC_2472 5377652 49.4 µM -0.894805716723955 0.219311746531731 no 2672 0.185445476923847 932 1610903 SGTC_2255 7941087 197.44 µM -0.895410678966578 0.219161888851907 no 2673 0.185283797070177 919 935561 SGTC_1085 doxorubicin 7.67 µM -0.895488452319116 0.21914262756718 no 2674 0.185263018018161 886 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3347 9188721 44.724 µM -0.89655912340395 0.218877564986687 no 2675 0.184977109167478 898 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3205 9113483 49.47 µM -0.89753717300962 0.218635593691231 no 2676 0.184716173430325 909 17018033 SGTC_2380 9035439 200 µM -0.900157053763505 0.2179881895394 no 2677 0.184018338610335 909 6462575 SGTC_2114 5491910 81.25 µM -0.902344012314994 0.217448613101364 no 2678 0.183437076241725 904 2849228 SGTC_2464 5717415 7.67 µM -0.902782308218703 0.217340567549713 no 2679 0.18332072127255 894 5285744 SGTC_1270 0831-1170 17.3 µM -0.903264318121337 0.217221781738419 no 2680 0.183192814639089 888 6764716 SGTC_641 4092-0595 30 µM -0.905028609125115 0.216787312425325 no 2681 0.182725115501696 918 786260 SGTC_2352 9027995 87.8 µM -0.905220908086096 0.216739987814153 no 2682 0.182674183710927 904 2997347 SGTC_182 3448-4371 550.524 µM -0.908550882565155 0.215921431886338 no 2683 0.181793621754786 882 3491403 SGTC_324 1315-0088 19.6 µM -0.909119963543055 0.215781722978999 no 2684 0.181643402895663 931 6787421 SGTC_833 3852-0053 558 µM -0.912181549688175 0.215031005860174 no 2685 0.180836577398357 934 3123681 SGTC_843 0310-0051 143 µM -0.91253466949204 0.214944516670379 no 2686 0.180743663783133 900 2065037 SGTC_634 1611-4317 11.2 µM -0.913604994645076 0.214682486737454 no 2687 0.180462220495504 920 2843522 SGTC_2049 5262831 67.185 µM -0.913799410398023 0.214634911086993 no 2688 0.180411128158177 912 763417 SGTC_3165 9101544 49.47 µM -0.915336345243335 0.214259022164956 no 2689 0.180007542157822 914 5002184 SGTC_2949 9072542 2.23 µM -0.915664776074547 0.214178747361304 no 2690 0.179921372589118 933 16457352 SGTC_1336 1486-0901 104 µM -0.916785430406164 0.213904969677656 no 2691 0.17962754438499 890 5006114 SGTC_3164 9100705 49.47 µM -0.919857733376895 0.213155446873564 no 2692 0.17882355436675 871 17174235 SGTC_1440 4100-1550 40 µM -0.922223065546102 0.212579442610789 no 2693 0.178206117103185 906 742806 SGTC_2278 7948257 134.34 µM -0.922301808613518 0.212560282795325 no 2694 0.17818558545096 905 1247028 SGTC_2926 9010726 65.15 µM -0.922646237459467 0.212476487995412 no 2695 0.178095795790357 940 2994293 SGTC_2079 5212404 121 µM -0.924397079707332 0.212050830643595 no 2696 0.177639807305495 905 758462 SGTC_1717 st033143 58.0435 µM -0.926822012231002 0.211462115673517 no 2697 0.177009477052211 911 674616 SGTC_542 3381-0244 89.3 µM -0.929703219319618 0.210763873977237 no 2698 0.176262383592776 947 1112843 SGTC_487 nimodipine 119 µM -0.931202831069869 0.210400988626303 no 2699 0.17587432685567 906 4497 L-type voltage-gated calcium channels inhibitor SGTC_2946 9065502 71.43 µM -0.931546758552634 0.210317814658023 no 2700 0.175785404570212 851 16489101 SGTC_2968 9090663 33.37 µM -0.934155267617698 0.209687612620631 no 2701 0.175111903206037 909 25236811 SGTC_2852 9023854 51.95 µM -0.9368442646293 0.209039128907791 no 2702 0.174419336148126 909 19798528 SGTC_2857 9024691 58.44 µM -0.941471020202274 0.207926100208574 no 2703 0.173231766738782 924 16478292 SGTC_2828 7998861 71.43 µM -0.94164992357023 0.207883132966249 no 2704 0.173185950470909 876 2988188 SGTC_1482 3346-2049 8.48 µM -0.942334082111384 0.207718866902395 no 2705 0.173010812043681 907 3826804 SGTC_2950 9072895 21.46 µM -0.944043492283544 0.207308773805243 no 2706 0.172573711795071 878 17332245 SGTC_1006 4099-6547 255 µM -0.94606606453444 0.206824170943522 no 2707 0.17205744557989 931 3146833 SGTC_1605 st000082 49.1 µM -0.947645701670636 0.206446160937081 no 2708 0.171654925950892 892 1114022 SGTC_734 2023-0417 80 µM -0.948012681624369 0.206358400604177 no 2709 0.171561499117206 931 3935732 SGTC_2713 st079149 53.4 µM -0.949702691023705 0.205954533743572 no 2710 0.171131671013421 896 3103253 SGTC_1392 3455-1037 33.9 µM -0.950736061746206 0.205707817038718 no 2711 0.170869188539165 885 981132 SGTC_2010 4012422 159 µM -0.951135034366997 0.205612609492844 no 2712 0.170767916024042 917 952393 SGTC_2754 granisetron 64.02 µM -0.952477810481131 0.205292372659894 no 2713 0.170427357085849 937 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1882 5615643 20 µM -0.953420568688877 0.205067712690987 no 2714 0.170188511985361 880 2253075 SGTC_3259 9138485 49.47 µM -0.956308881612108 0.204380335829167 no 2715 0.169458102028306 910 17646153 SGTC_2557 derrustone 83.84 µM -0.956666492503261 0.204295325116382 no 2716 0.169367807883416 917 629853 An antioxidant. SGTC_2839 9003951 25.97 µM -0.957418930718546 0.204116525423909 no 2717 0.16917792357641 898 2990634 SGTC_3137 9097352 49.47 µM -0.959458926632969 0.203632236322279 no 2718 0.168663800879565 896 44120435 SGTC_2186 6124449 200 µM -0.960027416228175 0.203497400717649 no 2719 0.168520708418955 902 3834182 YLR033W RSC58 SGTC_3302 9125395 16.351 µM -0.960905930189949 0.203289137627688 no 2720 0.168299734396452 897 17599668 SGTC_371 0195-0006 7.36 µM -0.961103816204357 0.20324224374873 no 2721 0.168249985540687 892 3928593 SGTC_1113 artemisinin 1.17947 µM -0.961892599804547 0.20305538655747 no 2722 0.168051778117327 910 2240 An anti-malaria and mitochondrial poison. SGTC_1332 1480-0653 17.5 µM -0.962508481400705 0.202909559952953 no 2723 0.167897122432698 925 5749438 SGTC_797 k781-0471 270 µM -0.964004779453253 0.202555531667744 no 2724 0.167521764835653 902 23738129 SGTC_116 0155-0182 31.788 µM -0.965080880829073 0.202301151500355 no 2725 0.167252151193403 830 771486 SGTC_1929 genistein trimethyl ether 50.5 µM -0.965298068181396 0.202249833652361 no 2726 0.167197769560759 895 136420 SGTC_1997 st073024 93.8 µM -0.966906862737112 0.201869944137072 no 2727 0.166795297803091 910 686268 SGTC_2356 9061756 188.97 µM -0.968079116614143 0.201593405535126 no 2728 0.166502429308043 910 20104043 SGTC_846 0335-0850 148 µM -0.969540002645082 0.201249095473988 no 2729 0.166137915701147 894 6819598 SGTC_2658 polymyxin b sulfate 77.05 µM -0.971357216954778 0.200821296313664 no 2730 0.165685212731131 924 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1688 st021091 57.6 µM -0.97314386328439 0.20040122581163 no 2731 0.165240903189311 960 3656366 SGTC_1039 k821-0043 94 µM -0.973551394287502 0.200305482422155 no 2732 0.165139665038082 928 15992768 SGTC_697 0508-1955 564 µM -0.973743780770303 0.200260293610921 no 2733 0.165091886672487 915 6243113 SGTC_617 3770-0098 35 µM -0.974073617763126 0.200182833912009 no 2734 0.165009993881849 913 5962639 SGTC_3212 9128307 49.47 µM -0.974444754894505 0.200095696723834 no 2735 0.164917878438807 935 27243542 SGTC_601 0986-0029 62.9 µM -0.974715670853724 0.200032104296225 no 2736 0.164850658707157 901 24747981 SGTC_2310 7668677 200 µM -0.977087835746451 0.199475802334664 no 2737 0.164262834689377 924 2197143 SGTC_16 erodoxin 22.806 µM -0.979044573374758 0.199017624871163 no 2738 0.163778978080721 923 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2453 5731132 22.18 µM -0.980504489757295 0.198676193389839 no 2739 0.163418577247482 951 1362040 SGTC_632 0781-2353 4.65 µM -0.981363412924785 0.198475481680865 no 2740 0.163206780890862 946 6811515 YHR007C ERG11 SGTC_2397 5161689 200 µM -0.983620137326207 0.197948717396166 no 2741 0.162651160074667 938 2259942 SGTC_1266 0828-0227 32.9 µM -0.984558957860255 0.197729826994126 no 2742 0.162420378965207 937 3913820 SGTC_2014 4013930 200 µM -0.985577721147164 0.19749246312277 no 2743 0.162170187532517 938 64556 SGTC_393 acivicin 6.25 µM -0.987835324147591 0.196967073569485 no 2744 0.16161665225227 904 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_631 k072-0230 41.5 µM -0.989556342768577 0.196567126876513 no 2745 0.161195508868599 954 5773147 SGTC_1019 4262-0212 3.4 µM -0.994495827106051 0.195421978060842 no 2746 0.159990767978722 926 4677213 SGTC_2124 5246320 200 µM -0.999122050395078 0.194353137585702 no 2747 0.158867785288413 920 579342 SGTC_2955 9076254 12.21 µM -1.00048235600272 0.194039531637008 no 2748 0.15853856604934 915 16459619 SGTC_1835 st008666 49.2 µM -1.0013078695554 0.193849367488495 no 2749 0.158338994735719 917 690455 SGTC_1522 st012842 45.6 µM -1.00395231441185 0.193240962055492 no 2750 0.15770079943162 907 3491067 YOR116C RPO31 SGTC_1960 st011366 51.8 µM -1.00490755076442 0.193021478389556 no 2751 0.15747068412375 926 3972846 SGTC_1091 telmisartan 47.6 µM -1.00801157255935 0.192309322172505 no 2752 0.156724453312948 953 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1303 1160-0052 261 µM -1.00840271701268 0.192219695983476 no 2753 0.156630584558147 903 3562476 SGTC_2237 6667747 47.222 µM -1.00919309670244 0.19203866769395 no 2754 0.156441018357222 954 729940 YDL015C TSC13 SGTC_3286 9117135 37.221 µM -1.01007452949753 0.191836907729607 no 2755 0.156229792070272 919 3438150 SGTC_3260 9137109 49.47 µM -1.01077345846161 0.191677015178434 no 2756 0.156062434568177 915 17478346 SGTC_875 0709-0210 25.7 µM -1.01269990056332 0.191236729636651 no 2757 0.155601762691133 942 6251364 SGTC_917 harmaline 728.087 nM -1.01508920038398 0.190691520739187 no 2758 0.155031654567374 900 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2586 curcumin 80 µM -1.01775052101406 0.190085364384547 no 2759 0.154398265694912 956 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1181 1222-0449 220 µM -1.01776745358714 0.190081511527719 no 2760 0.154394241262213 957 658318 SGTC_2695 st077686 51.995 µM -1.01852665839081 0.189908810529002 no 2761 0.154213869272407 943 2876092 SGTC_1569 carminic acid 40.6 µM -1.01930845230534 0.189731071896347 no 2762 0.154028276264843 918 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2866 9034245 58.44 µM -1.01936222888276 0.189718849705672 no 2763 0.154015515474605 917 6462273 SGTC_3342 9147791 14.508 µM -1.02297999170786 0.188897727050955 no 2764 0.153158653043822 928 1838168 SGTC_1041 0206-0046 107 µM -1.02442632051949 0.188570067809671 no 2765 0.152816977643031 948 50494 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.02472251165676 0.18850301030491 no 2766 0.152747068944789 916 756377 SGTC_2597 laccaic acid a 100 µM -1.02672373979914 0.188050318822548 no 2767 0.152275283718758 959 5491415 A textile dye. SGTC_1617 st002906 78 µM -1.02811305662831 0.187736440853342 no 2768 0.151948324776469 953 5150859 SGTC_477 mead ethanolamide 10 µM -1.02999669245495 0.187311402229477 no 2769 0.151505779116015 936 16061185 SGTC_2750 bromebric acid 70.15 µM -1.03104315951341 0.187075526330275 no 2770 0.151260290426667 949 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_590 k048-0076 22.4 µM -1.03259571256198 0.186725916249663 no 2771 0.150896567720169 946 6832814 SGTC_2685 mycophenolic acid 18.85 µM -1.03404590163426 0.186399722480822 no 2772 0.15055735250833 919 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2329 6138490 200 µM -1.03434664250143 0.186332120487147 no 2773 0.150487069540574 959 720019 SGTC_503 tyrphostin 8 294 µM -1.03799724388772 0.185512732271627 no 2774 0.149635669112543 973 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_988 1497-1057 103 µM -1.03927188589463 0.185227162655503 no 2775 0.149339153097175 939 3533044 SGTC_1861 st057647 17.4 µM -1.0441248586128 0.184142407446164 no 2776 0.148213813054967 938 688668 SGTC_1843 st055809 45.5 µM -1.04727446319959 0.183440516086835 no 2777 0.147486505226412 945 16413835 SGTC_3218 9131285 49.47 µM -1.04753554680006 0.183382408392328 no 2778 0.147426323214081 947 17156417 SGTC_1508 1080-0625 72.9 µM -1.04908865558585 0.183036980202014 no 2779 0.147068658421039 918 767111 SGTC_3117 9124945 49.47 µM -1.04922595330989 0.183006463245659 no 2780 0.147037068197903 929 17592065 SGTC_3223 9129970 49.47 µM -1.05150630381464 0.182500077522047 no 2781 0.146513057852407 954 17248386 SGTC_1664 st014217 9.02 µM -1.05186808574386 0.182419818984303 no 2782 0.146430037970979 926 3982782 SGTC_1373 2887-0003 58.5 µM -1.05227538943348 0.182329488185026 no 2783 0.146336609785602 957 776948 SGTC_606 k015-0008 38.6 µM -1.05268446676708 0.18223879216893 no 2784 0.14624281505421 977 1970475 SGTC_2860 9025725 38.96 µM -1.05364776891186 0.182025331069107 no 2785 0.146022105158215 963 40546248 SGTC_3002 9075603 71.4286 µM -1.05432729502148 0.181874846853636 no 2786 0.145866548151398 920 20105405 SGTC_1267 0828-0272 9.49 µM -1.05486531860856 0.181755754239505 no 2787 0.145743462903908 943 745334 SGTC_1652 st011932 78 µM -1.05909407574051 0.180821409649135 no 2788 0.144778468868266 936 1551076 SGTC_118 0083-0097 135.343 µM -1.05980563240309 0.180664487531773 no 2789 0.144616516944342 968 5207356 SGTC_1948 st076329 66.6 µM -1.06135432572941 0.180323243982896 no 2790 0.144264452805235 937 24208413 SGTC_1346 1488-2224 62.4 µM -1.06258273022134 0.180052861627856 no 2791 0.143985611075781 923 3722427 SGTC_1454 4239-0054 42.6 µM -1.06287533338666 0.17998849471985 no 2792 0.143919245248395 933 1340767 SGTC_3279 9140807 49.47 µM -1.06293676586944 0.17997498262439 no 2793 0.14390531426247 962 45595718 SGTC_3095 9117207 49.47 µM -1.06388983916564 0.179765435433241 no 2794 0.143689303257035 941 17015229 SGTC_474 dl-dihydrosphingosine 5 µM -1.06872287900536 0.178705181309753 no 2795 0.14259727952412 920 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2166 5933061 31.504 µM -1.0713929644446 0.178121119982307 no 2796 0.141996387485264 949 2877375 SGTC_1124 fisetin 1.16336 µM -1.07153160528651 0.178090826228551 no 2797 0.141965233802316 942 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1131 3454-3128 32.3 µM -1.07202564405177 0.17798290256924 no 2798 0.141854257049591 918 710982 SGTC_2700 st077718 96.8 µM -1.0721705469195 0.17795125609995 no 2799 0.141821718421378 952 904970 SGTC_1949 st076024 69.1 µM -1.07320302451291 0.177725867981464 no 2800 0.14159001698594 951 2921930 SGTC_1422 4031-0024 15.5 µM -1.07424577922524 0.177498419274165 no 2801 0.141356269671204 958 782427 SGTC_2338 7999974 200 µM -1.07431374214098 0.177483601384738 no 2802 0.141341043965496 932 315925 SGTC_183 3914-0051 30.55 µM -1.07613154124323 0.17708755816701 no 2803 0.140934215601058 941 1596232 SGTC_23 0213-0011 39.996 µM -1.07817936750457 0.176642068317597 no 2804 0.140476858857161 961 627608 SGTC_1519 esterone 74 µM -1.07821780618281 0.17663371304146 no 2805 0.140468283697872 952 698 A steroid. SGTC_44 0929-0055 61.211 µM -1.07844748041038 0.17658379479502 no 2806 0.140417053829664 930 1379590 SGTC_987 1497-1013 404 µM -1.07872583204359 0.176523308780589 no 2807 0.14035498325356 961 1676435 SGTC_278 4092-0821 23.9 µM -1.0790001206618 0.176463718482553 no 2808 0.140293836931779 954 877900 SGTC_412 gemfibrozil 100 µM -1.07955595218287 0.176343000889806 no 2809 0.140169982596743 935 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2348 9022543 33.42 µM -1.08014299735299 0.176215560948176 no 2810 0.140039253686347 934 3162678 YDL140C RPO21 SGTC_127 0180-0333 59.125 µM -1.08075219585898 0.176083373448218 no 2811 0.139903679073987 888 771601 SGTC_1011 4112-3381 17.4 µM -1.08300830033326 0.17559437744281 no 2812 0.139402369416785 941 2877139 SGTC_1403 3909-7815 62.9 µM -1.08335656536765 0.175518970001545 no 2813 0.139325093437609 927 6615483 SGTC_2511 berberine 10.47 µM -1.08393190455721 0.175394440717473 no 2814 0.139197496187861 944 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1732 st034308 51.822 µM -1.08457315905287 0.175255710418717 no 2815 0.139055374151335 921 830119 SGTC_2650 prasterone 100 µM -1.09313675970107 0.173409717153542 no 2816 0.137166879160269 929 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_263 alizarin 107.927 µM -1.09414754863545 0.173192648333088 no 2817 0.136945135657154 971 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2567 aureobasidin a 60 nM -1.09435386439158 0.173148362911248 no 2818 0.136899904916673 939 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3187 9109394 49.47 µM -1.09441184079377 0.173135919646437 no 2819 0.136887196549339 939 17098090 SGTC_2884 9058502 51.95 µM -1.09729447822705 0.172517947891899 no 2820 0.136256341959332 952 6471554 SGTC_1418 3966-3099 2.4 µM -1.09892407117557 0.17216922345298 no 2821 0.135900593097451 932 740335 SGTC_848 0368-0089 85.6 µM -1.09925825577484 0.172097765306064 no 2822 0.135827717466131 941 762535 SGTC_2745 rifampicin 24.3 µM -1.09935337427242 0.172077429734433 no 2823 0.135806979870093 917 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2243 6634756 200 µM -1.10016512610022 0.171903946108248 no 2824 0.135630091132982 949 885676 SGTC_1622 st003707 19.4 µM -1.10058695091936 0.171813839883989 no 2825 0.135538233688151 935 10140899 SGTC_1001 4048-4355 44.4 µM -1.1060140966504 0.170657235829665 no 2826 0.134360208981691 948 21824233 SGTC_203 k066-0004 30.888 µM -1.10694679865339 0.17045896645117 no 2827 0.134158465350735 991 6795412 SGTC_1004 4084-0029 199 µM -1.10997927011966 0.169815357994076 no 2828 0.133503979716046 951 716894 YLR208W SEC13 SGTC_2211 7117706 200 µM -1.11143386911215 0.169507189213732 no 2829 0.133190820267663 953 822771 SGTC_1306 1185-0270 9.02 µM -1.11302369635998 0.16917078190649 no 2830 0.13284912623362 953 1548076 SGTC_524 r073-0010 27.8 µM -1.11320198205691 0.169133083418508 no 2831 0.132810845808454 960 2772106 SGTC_2776 terbinafine 19.92 µM -1.11352256333905 0.169065310119039 no 2832 0.132742031647795 922 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_667 1498-1044 59 µM -1.11390884274793 0.168983670912371 no 2833 0.132659147725738 965 6739982 SGTC_389 tpck 16.7 µM -1.11563350724121 0.168619476280255 no 2834 0.132289521636709 966 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_661 1304-0007 33.6 µM -1.115684690976 0.168608675607751 no 2835 0.132278562914852 962 3117130 SGTC_2583 asiatic acid 100 µM -1.11705019752176 0.168320693797757 no 2836 0.131986431402625 971 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2316 5844804 197.44 µM -1.11779534929673 0.168163676712458 no 2837 0.131827204130239 946 776813 SGTC_662 k832-1615 104 µM -1.1181480690114 0.16808938510052 no 2838 0.131751879676798 964 5878478 SGTC_1556 plumbagin 1.48 µM -1.11872810354718 0.167967261219398 no 2839 0.131628075977617 924 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2034 5197015 53.07 µM -1.12471751240546 0.166709556613459 no 2840 0.130354379171546 967 780676 SGTC_1795 st049545 62.3 µM -1.12485279089278 0.166681220096662 no 2841 0.13032570989141 905 5291882 SGTC_938 3126-1755 342 µM -1.1263297853233 0.166372039240153 no 2842 0.130012977411332 939 1777771 SGTC_765 1319-0117 244 µM -1.1269369340287 0.166245051610218 no 2843 0.129884573114821 927 3487746 YGL099W LSG1 SGTC_881 0833-0569 170 µM -1.12973904221305 0.165659790677788 no 2844 0.129293100381834 957 5418700 SGTC_1775 st081588 35.1725 µM -1.13494450164752 0.16457609599882 no 2845 0.128199286233082 944 1426443 YGL099W LSG1 SGTC_2759 disulfiram 3.38 µM -1.13530972625131 0.164500234846952 no 2846 0.128122784208687 931 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_869 0564-0080 44.1 µM -1.13574307798883 0.164410252347717 no 2847 0.128032053026829 950 6843321 SGTC_2175 5807670 165.306 µM -1.1369097756997 0.164168154237518 no 2848 0.127788002525408 915 241186 SGTC_2086 5274770 176.623 µM -1.13866674294647 0.163804007479325 no 2849 0.127421089478858 940 689278 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.13918017026946 0.163697694254694 no 2850 0.127314007292463 988 688801 SGTC_18 0111-0177 500 nM -1.14052671249527 0.163419084290327 no 2851 0.127033465185702 971 721752 SGTC_1314 1222-0010 41.1 µM -1.14097021559071 0.163327387550096 no 2852 0.126941158855557 976 3526027 SGTC_1733 st037357 54.9 µM -1.14188562427251 0.163138227416396 no 2853 0.12675078244101 964 1272339 YGL099W LSG1 SGTC_2434 5670830 169.91 µM -1.14194183065519 0.163126617565628 no 2854 0.126739099750443 987 1549830 SGTC_1164 k060-0068 93.7 µM -1.14603448491172 0.162282692229641 no 2855 0.125890441790839 961 5963676 SGTC_344 k064-0035 6.43 µM -1.14659311088749 0.162167721667481 no 2856 0.125774912515586 933 5088750 SGTC_2847 9005661 71.43 µM -1.14775174050764 0.161929433745929 no 2857 0.125535532474007 949 2991449 SGTC_642 0335-0876 158 µM -1.14801853483572 0.161874596193664 no 2858 0.125480456180548 963 6812350 SGTC_2443 5493264 126.67 µM -1.1506084409305 0.161342889534518 no 2859 0.124946679416357 974 5340055 SGTC_2325 6158266 200 µM -1.15091062593479 0.161280925367846 no 2860 0.124884502914612 957 3623240 SGTC_1659 st012954 42.1 µM -1.15560410777904 0.160320502573718 no 2861 0.1239215635198 976 24207262 SGTC_2217 6934799 96.0675 µM -1.15650022455959 0.160137556857271 no 2862 0.123738303885773 966 675606 SGTC_955 1216-0110 33 µM -1.15688314964241 0.160059422854527 no 2863 0.123660051994153 961 3619719 SGTC_112 phenothiazine 287.218 µM -1.15768018330746 0.159896871961302 no 2864 0.123497286909048 966 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2811 7967822 32.47 µM -1.15832478088393 0.159765488622372 no 2865 0.123365761138252 955 2232244 SGTC_3061 glucosamine 200 µM -1.16241538622048 0.158933378930219 no 2866 0.122533388198669 939 91431 and experimental redox chemotherapeutic SGTC_884 0851-0618 334 µM -1.16285701320098 0.158843713471215 no 2867 0.122443760393852 961 9642473 SGTC_1968 st069590 43.6 µM -1.16523550772182 0.158361367585883 no 2868 0.121961838182168 954 6384066 SGTC_3133 9127736 49.47 µM -1.16535245567676 0.158337675981463 no 2869 0.12193817700901 942 27243420 SGTC_2730 imipramine 71.33 µM -1.16640786320836 0.158123974120576 no 2870 0.121724790425321 952 3696 A tricyclic antidepressant. SGTC_1821 st053465 65.6 µM -1.16812274700061 0.157777143560832 no 2871 0.121378628048324 974 675086 SGTC_1426 4048-4480 71.7 µM -1.16827887470087 0.15774559199505 no 2872 0.121347146891723 971 14224343 SGTC_3162 9099653 49.47 µM -1.16943275313308 0.157512535290369 no 2873 0.121114660050377 944 25237511 SGTC_340 k038-0059 454 µM -1.17024562105766 0.157348490721457 no 2874 0.120951069239057 955 23733424 SGTC_2807 7945238 51.95 µM -1.17369097405234 0.156654432588812 no 2875 0.120259413427116 986 17148797 SGTC_584 0986-0246 15.4 µM -1.17484851207821 0.156421702267581 no 2876 0.120027663842897 994 53315 YDR232W HEM1 SGTC_2080 5212524 12.4 µM -1.17549414508119 0.15629199264835 no 2877 0.119898539106863 950 260183 SGTC_1996 st072960 66.8 µM -1.1794292033905 0.155502959848252 no 2878 0.119113656078814 954 1719405 SGTC_3244 9134489 49.47 µM -1.18041894672525 0.155304917164491 no 2879 0.118916814994805 978 16584271 SGTC_2999 9069765 71.4286 µM -1.1813949726167 0.1551097823595 no 2880 0.118722927130492 964 2097066 SGTC_2688 kanamycin b 96.69 µM -1.1817279731673 0.155043243311303 no 2881 0.118656827586046 946 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1467 k284-1082 293 µM -1.18658188191886 0.154075491522795 no 2882 0.11769629298751 975 3334705 SGTC_2198 6589944 200 µM -1.19434729270698 0.152535584702935 no 2883 0.116171072615353 955 5290268 SGTC_2353 9059630 146.67 µM -1.19583049506531 0.152242626310628 no 2884 0.115881356491951 987 4779114 SGTC_2831 7999036 19.48 µM -1.19866812719632 0.151683185993402 no 2885 0.115328508059049 995 2988270 SGTC_2289 7946404 165.07 µM -1.19901044460793 0.151615790449437 no 2886 0.115261942183772 954 1246120 YPR165W RHO1 SGTC_1811 st050069 61.5 µM -1.20000481335695 0.151420131766374 no 2887 0.11506873553761 967 3877702 SGTC_1172 0370-0043 85 µM -1.20163804236057 0.151099131157013 no 2888 0.114751897797124 989 376585 SGTC_3235 9132602 49.47 µM -1.20377148303744 0.150680499688111 no 2889 0.114338957313526 973 4912240 SGTC_2507 purpurin 79.67 µM -1.20390983885176 0.150653377702082 no 2890 0.114312214279475 974 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_943 3253-1379 105 µM -1.20449508409198 0.150538687635733 no 2891 0.114199140484035 967 668464 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.20466238049426 0.15050591337781 no 2892 0.114166832201928 975 2333 A French combination drug. SGTC_2571 chrysanthemic acid 100 µM -1.20484710535071 0.150469730314755 no 2893 0.114131165699972 1006 2743 An insecticide. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.20692205605895 0.150063696568961 no 2894 0.113731081344083 973 1609 A potent and irreversible inhibitor of serine proteases. SGTC_50 0929-0078 56.389 µM -1.20731706293461 0.149986483059695 no 2895 0.113655030978504 940 1377751 SGTC_1941 st076221 61.8 µM -1.21106877821777 0.149254441700154 no 2896 0.112934523063023 922 2828568 SGTC_1792 st045773 43.6 µM -1.21169757690624 0.149131983212384 no 2897 0.112814083505664 921 2919270 SGTC_296 1222-0039 74.9 µM -1.21328110423112 0.148823888769741 no 2898 0.112511182379112 978 5984176 SGTC_740 k014-0057 261 µM -1.21364118938649 0.148753889238145 no 2899 0.112442385523669 978 4012779 SGTC_2358 9037157 4 µM -1.21399001276189 0.148686099951931 no 2900 0.11237576897542 959 2388925 SGTC_1915 st067105 30.6 µM -1.21571301031402 0.148351560739071 no 2901 0.112047133143468 964 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_430 0958-0115 16.4 µM -1.21720504340784 0.148062272920042 no 2902 0.111763105891655 972 6833180 SGTC_1339 1486-1321 22.7 µM -1.21731948887625 0.148040098878745 no 2903 0.111741341043338 978 3469382 SGTC_608 k048-0125 159 µM -1.21829581011115 0.147851025019368 no 2904 0.111555790852357 975 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_458 nppb 133 µM -1.2200211027678 0.147517301198725 no 2905 0.11122843761407 995 4549 A chloride channel blocker. SGTC_1824 st053723 68.6 µM -1.2256349163234 0.146434914486011 no 2906 0.110168046078078 982 675225 SGTC_318 1488-0629 67.2 µM -1.22668208745603 0.146233603309266 no 2907 0.109971051382596 990 3662576 SGTC_1309 pyrazolanthrone 13.4 µM -1.22691426308489 0.146188994386383 no 2908 0.109927408566339 977 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_512 prima-1 270 µM -1.22976615134884 0.145641794226849 no 2909 0.109392343472874 981 322968 A re-activator of the apoptotic function of mutant p53. SGTC_716 1683-5115 658 µM -1.2299600865373 0.145604633386478 no 2910 0.109356025823015 979 723597 SGTC_2024 5144227 134 µM -1.23113456744618 0.145379721756888 no 2911 0.109136269417848 978 3475211 SGTC_1829 berberine 14.4 µM -1.23356806250562 0.144914454580893 no 2912 0.108681950000972 936 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_783 0848-0141 92.7 µM -1.2350591815828 0.144629858955101 no 2913 0.108404239659856 975 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3166 9102297 49.47 µM -1.23752234176637 0.14416056430144 no 2914 0.107946612583514 973 25237072 SGTC_1499 4480-0877 67.3 µM -1.2425044922902 0.143214479488226 no 2915 0.107025242029116 962 2861909 SGTC_2998 9066762 71.4286 µM -1.24516279726448 0.142711400578155 no 2916 0.106535957328016 979 4945196 SGTC_2765 myclobutanil 7.74 µM -1.2464196122596 0.142473967306976 no 2917 0.106305192378422 991 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.24810382675327 0.142156210298927 no 2918 0.105996518536331 1009 91467 include heat shock SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.25185459945773 0.141450284881992 no 2919 0.105311425305672 991 6728940 SGTC_2303 7774051 200 µM -1.25231689410417 0.141363442062209 no 2920 0.105227207651913 983 2953184 SGTC_500 h-89 112 µM -1.25551548246766 0.140763571986837 no 2921 0.104645845631171 989 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1954 st077032 68.9 µM -1.2567613813087 0.140530381569137 no 2922 0.104420027006079 997 698907 SGTC_2238 6671620 73.2395 µM -1.26118943756926 0.139703721290042 no 2923 0.103620301618394 968 729941 SGTC_157 1348-1695 65.819 µM -1.26469790543675 0.139051088241246 no 2924 0.102989820549469 957 5380510 SGTC_1516 st013856 110 µM -1.26752812325689 0.138526135582808 no 2925 0.102483257122707 996 5281404 A mutagen and neurotoxin. SGTC_1118 chelidonine 707.474 nM -1.26788338001607 0.138460337592006 no 2926 0.10241980007094 990 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3158 9100007 49.47 µM -1.26870265820935 0.13830867823821 no 2927 0.102273567019302 994 19297233 SGTC_1279 0874-0590 65.2 µM -1.27264716466808 0.137580082665549 no 2928 0.10157163706426 993 3523074 SGTC_3037 9091026 49.47 µM -1.2729273171396 0.13752843512127 no 2929 0.101521917336827 982 25236398 YIL048W NEO1 SGTC_1076 itraconazole 331 nM -1.27415793454035 0.137301721270769 no 2930 0.101303724908892 989 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1490 4089-0339 670 nM -1.27554014587652 0.13704738410941 no 2931 0.10105906199731 979 742542 SGTC_1020 4335-0961 93.3 µM -1.2777677253023 0.136638170742186 no 2932 0.100665668735777 1007 669075 SGTC_1656 st012921 11 µM -1.27989875318781 0.136247476908551 no 2933 0.100290373099873 984 6732821 SGTC_2766 oltipraz 83.91 µM -1.27993149356527 0.136241480391683 no 2934 0.100284615163129 928 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1232 0279-0259 161 µM -1.28169401829384 0.135918934230841 no 2935 0.0999750020621024 983 1560000 SGTC_413 propylparaben 100 µM -1.28364926912155 0.135561730920329 no 2936 0.0996323511905463 978 7175 A pharmaceutical preservative. SGTC_2252 omeprazole 400 µM -1.28585249152846 0.135159997211321 no 2937 0.0992472733549554 989 4594 A proton pump inhibitor. SGTC_2188 6126565 140.678 µM -1.29835076135813 0.132896528228244 no 2938 0.0970834153562783 982 874518 SGTC_862 0452-0056 10.2 µM -1.30245818218084 0.132158394478786 no 2939 0.0963799021624543 1010 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2791 5663188 71.43 µM -1.30273117799262 0.132109435496888 no 2940 0.0963332769482441 984 54690634 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.30341931110125 0.131986081421685 no 2941 0.0962158235992211 994 16486 A toxic proline analog. SGTC_1766 st045414 44.774 µM -1.30634641075002 0.131462260111592 no 2942 0.0957173904841218 973 253960 SGTC_2032 5185112 25.99 µM -1.30701874414902 0.131342145146494 no 2943 0.0956031727987963 975 5718189 SGTC_3008 9078912 71.4286 µM -1.30821031768152 0.131129452133706 no 2944 0.0954009917379154 1012 16648731 SGTC_1757 st041620 31.8375 µM -1.30980025710497 0.130846022472945 no 2945 0.0951317080793656 1015 5289815 SGTC_507 nimesulide 162 µM -1.31119100414298 0.130598449120421 no 2946 0.0948966204243079 999 4495 A COX2 inhibitor. SGTC_1338 1486-1223 76 µM -1.31191809581443 0.130469145160044 no 2947 0.0947738855692116 993 3444526 SGTC_919 tnp00227 403.569 nM -1.31296818656447 0.130282556262625 no 2948 0.0945968342076875 997 1269246 A methoxyflavone. YNL221C POP1 SGTC_3106 9121286 49.47 µM -1.31420296011661 0.13006338765772 no 2949 0.0943889563140907 965 15943471 SGTC_2723 salbutamol 83.58 µM -1.318405839878 0.129319302216101 no 2950 0.0936839134535202 985 9884233 β2-adrenoceptor agonist SGTC_51 1013-0126 23.419 µM -1.31876039713655 0.129256665971121 no 2951 0.0936246139696323 992 1627850 SGTC_1161 k007-0610 110 µM -1.32035841813903 0.128974619850794 no 2952 0.0933576898826009 970 5843850 SGTC_1642 st009582 77.7 µM -1.32038360336039 0.12897017815046 no 2953 0.0933534875950481 989 6739311 SGTC_1492 4158-0558 28.5 µM -1.32204961178937 0.128676594192584 no 2954 0.0930758155361569 960 3967268 SGTC_451 chloral hydrate 100 µM -1.32381012073622 0.128366861624198 no 2955 0.0927830570268915 1000 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2894 9048625 32.47 µM -1.32431954576879 0.128277333312809 no 2956 0.0926984708942645 991 4092861 SGTC_373 0844-0104 25.9 µM -1.32615505576191 0.127955113332121 no 2957 0.0923941714384543 983 5375804 SGTC_495 decylubiquinone 155 µM -1.32906366931414 0.127445664643753 no 2958 0.0919134825641061 997 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_24 0417-1663 219 µM -1.33132919688268 0.127049832051277 no 2959 0.0915403576369507 1025 4329390 SGTC_2899 9053889 58.44 µM -1.3313900427358 0.127039212885144 no 2960 0.0915303520271474 987 6470052 SGTC_572 0960-0087 17.7 µM -1.33379754171867 0.126619538074076 no 2961 0.0911351084334213 1008 6796365 SGTC_1982 st072467 71.9 µM -1.33440829317865 0.126513225709303 no 2962 0.0910350418015955 992 3163533 SGTC_2421 5690543 90.72 µM -1.3346276238875 0.12647506240181 no 2963 0.0909991261544427 1003 3397993 SGTC_2953 9074162 66.49 µM -1.3347612827662 0.126451809833866 no 2964 0.0909772445194898 979 16451992 SGTC_283 0987-0079 11.7 µM -1.33636389037718 0.126173236929832 no 2965 0.0907151814552986 999 411556 SGTC_3333 9141820 12.094 µM -1.33697797540439 0.126066607183676 no 2966 0.0906149130857194 988 1939433 SGTC_3069 9117009 49.47 µM -1.33958360490668 0.125614864490437 no 2967 0.0901903784770729 991 41904981 SGTC_3261 9137475 49.47 µM -1.34150221961921 0.125282953648744 no 2968 0.0898787247756749 954 17027690 SGTC_2770 toltrazuril 17.5 µM -1.34351638792242 0.124935171826133 no 2969 0.0895524115863993 971 68591 Kills coccidiodes. SGTC_1788 fluconazole 20 µM -1.34414023108959 0.124827591186042 no 2970 0.0894515223526721 998 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2389 9091542 195.52 µM -1.34491414440742 0.124694221197529 no 2971 0.0893264809776752 980 3626624 YOL127W RPL25 SGTC_3293 9120939 62.045 µM -1.34966888546297 0.123877012967936 no 2972 0.0885611085585263 1003 934087 SGTC_1679 SEC14.276 6.7 µM -1.35072484463179 0.123696032719969 no 2973 0.0883917953142914 982 1005053 YMR079W SEC14 SGTC_2262 9014885 67.46 µM -1.35252540759889 0.123387862378717 no 2974 0.0881036482492778 1015 6457424 SGTC_1475 4092-1048 11.7 µM -1.35491340587528 0.122979981470915 no 2975 0.0877225739751827 1015 2881759 SGTC_2004 4023728 41.89 µM -1.3550688057089 0.122953471273733 no 2976 0.0876978181112746 992 360084 YDR527W RBA50 SGTC_1878 temozolomide 1 mM -1.35599209145333 0.122796047371789 no 2977 0.0875508421761301 982 5394 DNA alkylating agent. SGTC_1718 roemerine 11.9335 µM -1.35765582243335 0.122512731573501 no 2978 0.0872864604803333 935 235224 An aporphine alkaloid with mutagenic activity. SGTC_3240 9133527 49.47 µM -1.3585066061573 0.122368029475827 no 2979 0.0871514939056557 1001 17617455 SGTC_2084 5306078 60.6385 µM -1.35969656255486 0.122165841852588 no 2980 0.0869629831803936 1013 679340 SGTC_1395 3486-0190 4.35 µM -1.36293971868665 0.121615982538638 no 2981 0.0864507548158454 1009 6748079 SGTC_1790 st045711 43.5 µM -1.36487312052493 0.121289013610277 no 2982 0.0861464659152939 963 585119 SGTC_3099 9120367 49.47 µM -1.37092128503108 0.120270166396618 no 2983 0.0851997476624286 1014 24824940 SGTC_1977 st070720 65.3 µM -1.37108469515884 0.120242722951137 no 2984 0.0851742776944892 995 682188 SGTC_77 0828-0286 12.516 µM -1.37199405543482 0.120090083636367 no 2985 0.0850326441956461 993 745345 SGTC_885 0865-0106 16.8 µM -1.37703532856596 0.11924636510343 no 2986 0.0842506627419354 1005 2793380 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.37903120612003 0.118913489469504 no 2987 0.0839425662922166 1005 5377381 SGTC_2371 9071574 200 µM -1.38215242080298 0.118394244819888 no 2988 0.0834624528166628 1023 45596039 SGTC_669 0108-0021 26.2 µM -1.38394270528793 0.118097137769457 no 2989 0.0831879995152214 1007 17201 SGTC_515 4092-1064 102 µM -1.38507962486464 0.117908734019703 no 2990 0.0830140606842216 1026 717353 SGTC_2667 digitoxin 100 µM -1.38579079078228 0.117790991873943 no 2991 0.0829053976255927 964 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_785 1270-0111 65.3 µM -1.38600841269694 0.117754978557068 no 2992 0.0828721673347006 987 6741994 SGTC_3246 9135460 32.98 µM -1.39153575124825 0.116842894225157 no 2993 0.0820315131288566 1001 41446951 SGTC_2625 euphol 100 µM -1.39441162056604 0.116370323145162 no 2994 0.0815966704860479 995 6708538 A triterpene alcohol. SGTC_643 k048-0106 28.4 µM -1.39467435927987 0.116327216863886 no 2995 0.0815570301792533 1013 6763920 SGTC_3340 9146634 11.102 µM -1.39507889422617 0.116260868906436 no 2996 0.0814960249736744 996 4907387 SGTC_19 0279-0214 38.434 µM -1.39630891076277 0.11605929830453 no 2997 0.0813107458092659 1020 3566274 YBR002C RER2 SGTC_3116 9124943 49.47 µM -1.3968686283656 0.115967656008788 no 2998 0.0812265400128904 987 41905195 YPL160W CDC60 SGTC_1460 k062-0059 9.15 µM -1.39823027491903 0.115744928810776 no 2999 0.0810219640725402 988 1373085 SGTC_3349 9149703 23.001 µM -1.40150779412106 0.115210064786644 no 3000 0.0805311392369698 1018 4910494 SGTC_2077 5212015 200 µM -1.40249145668114 0.115049882544358 no 3001 0.0803842699565373 992 780900 SGTC_2436 5633522 8.09 µM -1.40363765379944 0.114863432603142 no 3002 0.0802133882855045 1020 5724242 SGTC_1203 3992-3522 103 µM -1.40661202386713 0.114380599743264 no 3003 0.0797712328548967 1021 5322312 SGTC_717 1532-0246 73.2 µM -1.40695311355569 0.114325322760497 no 3004 0.0797206461732673 996 9561992 SGTC_651 3253-0966 34.4 µM -1.40807182220835 0.114144158382986 no 3005 0.0795549018872914 1022 781462 SGTC_1228 0124-0032 52.5 µM -1.40841407460921 0.114088774684843 no 3006 0.0795042469932971 1002 X1228 SGTC_2041 5107442 45.335 µM -1.408540336376 0.114068347687084 no 3007 0.0794855658485228 1013 793005 SGTC_2088 5278280 127.392 µM -1.41236193203789 0.113451311163401 no 3008 0.0789217096821681 1004 791502 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.41791479399077 0.112558991464557 no 3009 0.0781078213254446 990 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2248 tofa 1.1 µM -1.41964251997016 0.112282378995209 no 3010 0.0778558900045912 982 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2350 9023895 38.85 µM -1.4206469007994 0.112121799023485 no 3011 0.0777097182179815 990 2997209 SGTC_732 3970-1727 52.7 µM -1.42401038681791 0.111585241883361 no 3012 0.0772217326731576 1016 1275699 SGTC_1434 4073-0095 163 µM -1.42770995191028 0.110997196556903 no 3013 0.0766876802559162 1003 24133745 SGTC_1451 4152-0210 104 µM -1.427890945568 0.110968484701076 no 3014 0.0766616250810978 1022 659563 SGTC_705 1124-0212 310 µM -1.43391358663008 0.110016117390183 no 3015 0.0757984620726438 999 9554485 SGTC_1822 st052468 42 µM -1.43404698449064 0.109995089621714 no 3016 0.07577942767331 1008 2873678 SGTC_2519 cryptotanshinone 88.04 µM -1.43462224302674 0.10990444351358 no 3017 0.0756973863422985 1000 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1116 jasmonic acid  1.58368 µM -1.4358190987761 0.109716021321737 no 3018 0.0755269118754217 1013 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1609 st001574 46.4 µM -1.43645055673497 0.109616703767975 no 3019 0.075437087962673 998 3960012 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.43797998886178 0.109376417768786 no 3020 0.0752198660463136 1021 688751 SGTC_3018 9082602 49.47 µM -1.43980465803224 0.109090242908676 no 3021 0.0749613364889678 988 17332089 SGTC_1655 st012546 55.1 µM -1.44122816755734 0.108867358499534 no 3022 0.0747601165793241 1018 720985 YLR208W SEC13 SGTC_2669 eugenol 100 µM -1.44351562724005 0.108509888131581 no 3023 0.0744376367694942 1008 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_753 1322-0200 289 µM -1.4442451845948 0.108396055121481 no 3024 0.0743350094504866 1023 5403907 SGTC_1844 rapamycin 4 nM -1.44768735123928 0.107860132109526 no 3025 0.0738522545019603 957 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1698 5-fluorocytosine 1.055 µM -1.45085021534628 0.107369379457436 no 3026 0.0734107866590504 1001 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_552 k242-0005 476 µM -1.451718322742 0.107234965137306 no 3027 0.0732899712396342 1025 4088318 SGTC_3024 9090631 49.47 µM -1.45470829338645 0.106772938560683 no 3028 0.0728750178208624 1000 25236383 SGTC_102 gallobenzophenone 83.616 µM -1.45555710719207 0.106642037387724 no 3029 0.0727575463192554 999 70837 SGTC_2779 methotrexate 400 µM -1.45770092814076 0.106311940441665 no 3030 0.0724614980123464 989 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.45880162131376 0.10614274710226 no 3031 0.0723098581244863 1023 521171 SGTC_561 1550-0330 72.9 µM -1.46161816318285 0.105710687564827 no 3032 0.0719229371390469 1024 6812934 SGTC_2140 5586273 200 µM -1.46249025488581 0.1055771662243 no 3033 0.0718034564416701 1022 854421 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.46331578497189 0.105450886087998 no 3034 0.0716904952204367 987 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_819 1013-0258 27.7 µM -1.46659134650465 0.104950904947435 no 3035 0.0712436277347633 1017 5753198 SGTC_2311 7694451 200 µM -1.46777564196409 0.104770557368988 no 3036 0.0710825879960172 1019 2163142 SGTC_337 1315-0038 354 µM -1.4683689120321 0.104680297084859 no 3037 0.0710020206766428 1019 1626437 SGTC_73 0327-0325 16.231 µM -1.47987749901461 0.102940506985878 no 3038 0.0694529707713729 952 53298 SGTC_2179 6298986 200 µM -1.48164123530819 0.102675744563552 no 3039 0.0692178904610962 971 738374 SGTC_2840 9008771 71.43 µM -1.49253061030378 0.101052046773856 no 3040 0.0677800494020796 1011 2992978 SGTC_2336 9001819 198.65 µM -1.49481254149747 0.100714176537763 no 3041 0.0674816861461512 996 2989602 SGTC_425 3825-7017 13.1 µM -1.49794659504117 0.100251482162183 no 3042 0.0670735631560463 1018 3397440 SGTC_97 0535-0701 19.132 µM -1.50040039989223 0.0998903003601466 no 3043 0.0667553580089823 987 2832013 YGL099W LSG1 SGTC_1891 st059073 26.2 µM -1.50431594244981 0.0993159314295371 no 3044 0.0662500180364397 1032 688754 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.5068936722459 0.0989391258986296 no 3045 0.0659189568319396 1013 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1498 4478-3555 97.6 µM -1.50751027606055 0.0988491476436578 no 3046 0.0658399559280914 1029 3437919 SGTC_1264 0783-0040 158 µM -1.51093996572192 0.0983497608278986 no 3047 0.0654018735727424 1009 2855798 SGTC_338 4055-0136 114 µM -1.51113245813194 0.0983217874454106 no 3048 0.0653773532327627 1044 2900563 SGTC_1399 3562-5772 25 µM -1.51120831689478 0.0983107650989195 no 3049 0.06536769204377 1014 23847490 SGTC_3316 9136639 10.545 µM -1.51242398842985 0.098134250373488 no 3050 0.0652130180844716 1000 4903665 SGTC_1251 0490-5699 265 µM -1.51361453751822 0.0979616085601925 no 3051 0.0650618159173661 1027 3883818 SGTC_1079 idarubicin 2.36 µM -1.51827124847116 0.0972884756000795 no 3052 0.0644730163185332 1018 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2856 9022925 19.48 µM -1.52088712263835 0.096911839755891 no 3053 0.0641440830168867 1024 4944862 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.52289173817843 0.0966239387813215 no 3054 0.0638928965551593 1010 17037758 SGTC_1553 gossypol 38.6 µM -1.52340208076474 0.096550744297234 no 3055 0.0638290708848559 1009 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2843 9000894 45.46 µM -1.52471739312919 0.0963622870263404 no 3056 0.0636648007926005 990 2242070 SGTC_2541 muurolladie-3-one 83.07 µM -1.52879650576556 0.0957795532234205 no 3057 0.0631574494480426 990 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_264 promethazine 12.5 mM -1.52983670795939 0.0956313677160308 no 3058 0.0630285764670867 1021 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1209 2323-2347 50.3 µM -1.5314282576673 0.0954049647701497 no 3059 0.0628317923669424 991 5412760 SGTC_3086 9117350 49.47 µM -1.54009389144482 0.0941791705746128 no 3060 0.0617687342810523 1003 2679265 SGTC_2837 9008476 45.46 µM -1.54181446015659 0.0939371767128456 no 3061 0.0615593435753835 1021 2992805 SGTC_1611 st001856 99.4 µM -1.54263948899514 0.0938213012961576 no 3062 0.0614591355953147 1036 647478 SGTC_1739 st037196 92.5 µM -1.54420069570497 0.0936023183856751 no 3063 0.0612698601854206 1014 612214 SGTC_2182 6325192 200 µM -1.54623954764432 0.0933169070890435 no 3064 0.061023362834037 1005 736248 SGTC_1476 4112-3294 3.34 µM -1.54961640883938 0.0928456080078496 no 3065 0.0606168060807537 980 704369 SGTC_3175 9106517 49.47 µM -1.55307186473904 0.0923651639923711 no 3066 0.0602029834175385 1039 41468073 SGTC_964 1287-0107 19.4 µM -1.55494909924267 0.0921049271858181 no 3067 0.059979096218429 1023 51516812 YPR165W RHO1 SGTC_2666 tannic acid 100 µM -1.55608108670936 0.0919482648882672 no 3068 0.0598444059105793 1013 16134267 A thiamine antagonist. SGTC_2520 obtusaquinone 4.71 µM -1.55905119949878 0.0915381520732542 no 3069 0.059492131286596 1011 5967872 SGTC_940 3232-1287 54.8 µM -1.5653280010088 0.0906759143977198 no 3070 0.0587530104111138 1029 1585493 YIL048W NEO1 SGTC_796 1234-0020 70.7 µM -1.56815966118094 0.0902889112360567 no 3071 0.0584219379429167 999 46495034 SGTC_3329 9141233 27.5565 µM -1.57305284595245 0.0896230530499624 no 3072 0.0578532910985629 1004 4909101 YNL103W MET4 SGTC_3064 1327-0027 10 µM -1.57846762721747 0.0888904802316539 no 3073 0.057229109792168 1014 16000455 YPR107C YTH1 SGTC_1534 6-azauridine 81.6 µM -1.57906403108217 0.0888100653267229 no 3074 0.0571606854404749 1029 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2630 antimycin a 100 µM -1.58193552747309 0.088423651067349 no 3075 0.0568321447266796 1036 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1371 2421-0008 32.7 µM -1.58221875345304 0.0883856056248964 no 3076 0.0567998203213673 1009 2827552 SGTC_2824 7998404 51.95 µM -1.58442757324738 0.088089315647124 no 3077 0.0565482256676439 1032 837851 SGTC_249 wiskostatin 11.211 µM -1.58789634448074 0.0876255119331345 no 3078 0.0561548901249773 1009 2775510 A n-wasp and actin depolymerizer. SGTC_3149 9097855 49.47 µM -1.58987015831502 0.087362411210093 no 3079 0.0559320377341704 1021 25236625 YMR079W SEC14 SGTC_2052 5265182 7.135 µM -1.59172922856304 0.0871151450048846 no 3080 0.0557227789621001 1026 1239884 SGTC_410 α-linolenic acid 100 µM -1.59526854137387 0.0866458429256756 no 3081 0.0553260986139225 1038 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2616 abietic acid 100 µM -1.5967417874766 0.0864510529298849 no 3082 0.0551616383733002 1035 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.60407723570984 0.0854860442806212 no 3083 0.054348514500973 987 688669 SGTC_1238 0333-0287 48.8 µM -1.60523224595422 0.085334835900148 no 3084 0.0542213517679993 1028 7226 SGTC_1526 st051518 75 µM -1.60755735776734 0.0850310512348571 no 3085 0.0539660788851963 1026 673993 SGTC_151 3013-0144 2.285 µM -1.6091012003468 0.0848297905965064 no 3086 0.0537971074195194 1019 906558 YHR107C CDC12 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.61073157888933 0.0846176368143215 no 3087 0.0536191198428547 1044 4174840 SGTC_1192 1488-0095 21.4 µM -1.61194662449651 0.0844597874169922 no 3088 0.0534867775615676 1042 915875 SGTC_2742 clothiapine 36.27 µM -1.61638692954189 0.0838848157030994 no 3089 0.0530053412504221 1048 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_153 4077-0274 519.67 µM -1.61937612786326 0.083499405511674 no 3090 0.0526831799803025 1025 3121976 SGTC_2201 6605497 169.863 µM -1.61955963544718 0.0834757885172382 no 3091 0.0526634531558852 1044 670741 SGTC_3249 9135183 49.47 µM -1.6208003443365 0.0833162438974549 no 3092 0.0525302323226718 991 4902779 SGTC_2867 9039098 71.43 µM -1.62558761255923 0.0827027901532418 no 3093 0.0520187060739 1018 6463460 SGTC_1269 0831-0796 3.05 µM -1.63155581796794 0.0819427758491316 no 3094 0.0513865460511038 992 927758 SGTC_1794 st048918 76.9 µM -1.63371744092209 0.081668808630572 no 3095 0.0511590972426339 981 672303 SGTC_2413 inermin 26.06 µM -1.63644417336626 0.0813242042838038 no 3096 0.0508733302902898 1004 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2167 5876490 200 µM -1.64139700265454 0.0807010732915512 no 3097 0.0503575158397229 1029 686534 SGTC_1813 st051246 8.6015 µM -1.64424263654989 0.0803446898281003 no 3098 0.0500630465576758 1036 5291959 SGTC_107 0358-0022 2.6945 µM -1.64621644255457 0.0800981923501187 no 3099 0.0498596026019985 1052 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2022 5136654 200 µM -1.64870835690089 0.0797878082777996 no 3100 0.0496036986366094 1036 1713771 SGTC_2447 5741742 33.78 µM -1.6492074753347 0.0797257493453835 no 3101 0.0495525685148754 1035 1776504 SGTC_3123 9126162 49.47 µM -1.65192208709609 0.0793888616152471 no 3102 0.0492752174260642 1022 25239884 SGTC_1974 st069448 26.9 µM -1.65621209434653 0.0788586632078005 no 3103 0.0488394374257024 1032 6323587 YNR016C ACC1 SGTC_836 0330-0104 1.35 µM -1.65851353921106 0.0785753373720597 no 3104 0.048606928525266 1018 46494820 SGTC_2307 7538926 6.34 µM -1.66080758908141 0.0782936904420902 no 3105 0.0483760482483662 1021 96582 SGTC_1696 st025591 34.7925 µM -1.66100558676815 0.0782694176470881 no 3106 0.0483561623377792 1026 2787147 SGTC_3035 9091303 49.47 µM -1.66123432390112 0.0782413835683309 no 3107 0.0483331972492924 1053 25237002 SGTC_2382 9035899 200 µM -1.66346183193639 0.077968777690505 no 3108 0.0481100124706964 1044 6462679 SGTC_984 1492-0255 2.91 µM -1.66364742824028 0.0779460966937623 no 3109 0.0480914539620427 1046 1585198 SGTC_2100 5377183 190 µM -1.66603561862551 0.0776546918311359 no 3110 0.0478531601454201 1010 2844202 SGTC_2651 TUB2.036 5 µM -1.66765370160532 0.0774577253086413 no 3111 0.0476922455948896 1009 15992207 YFL037W TUB2 SGTC_925 2064-1272 59.6 µM -1.66957752012698 0.0772240361057669 no 3112 0.0475014905691919 1034 6815817 SGTC_284 0988-0104 32.6 µM -1.67412221721546 0.0766741124995821 no 3113 0.0470532910999648 1034 4666532 SGTC_480 am 92016 50 µM -1.67577349303353 0.0764750418938854 no 3114 0.0468912840254034 1054 2129 K+ channel blocker. SGTC_1547 harmine 94.2 µM -1.67780276404438 0.0762309406340198 no 3115 0.0466928047947438 1017 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2137 5261020 140 µM -1.67799271934175 0.0762081212745171 no 3116 0.046674260172868 1039 763655 SGTC_409 arachidonic acid 100 µM -1.67919272396373 0.0760640846785165 no 3117 0.0465572447786466 1035 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_330 1488-0319 80.1 µM -1.68497952795256 0.0753724024580909 no 3118 0.045996260668005 1028 6846614 SGTC_1493 4348-0038 111 µM -1.69296255855928 0.0744260928147609 no 3119 0.0452312971167222 1036 800424 SGTC_2729 fluphenazine 10.66 µM -1.69684779511195 0.0739688304983604 no 3120 0.0448627199803257 1036 3372 An atypical antipsychotic. SGTC_1649 st011737 51.3 µM -1.69903940246712 0.07371184389595 no 3121 0.0446558798625284 1007 1761035 SGTC_621 3584-0052 32.1 µM -1.70060041803904 0.0735292167046744 no 3122 0.0445090228086523 1039 2273927 SGTC_3129 9127257 49.47 µM -1.70273397581631 0.0732801662129819 no 3123 0.0443089317842472 1040 837894 SGTC_1483 3453-0561 55.9 µM -1.70276715302001 0.0732762985352202 no 3124 0.0443058260668667 1036 4546991 SGTC_198 3454-2873 16.191 µM -1.70813181964246 0.0726529570338923 no 3125 0.0438059429554016 1036 710957 SGTC_3132 9126706 49.47 µM -1.71439322346784 0.0719305652641953 no 3126 0.0432282661221307 1040 850858 SGTC_2640 pentamidine 10.38 µM -1.71502560634824 0.0718579131889297 no 3127 0.0431702661607629 979 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1978 st071761 42 µM -1.71504718318099 0.0718554353014775 no 3128 0.043168288318014 1040 5147680 SGTC_1786 berberine 21.6 µM -1.71564452296133 0.071786862706047 no 3129 0.0431135621549727 994 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3087 9117406 49.47 µM -1.71621169428924 0.0717217998115562 no 3130 0.0430616518004403 1035 42546093 SGTC_2810 7959871 45.46 µM -1.71928511450277 0.071370019720105 no 3131 0.042781234531334 1033 2974535 SGTC_1057 3448-5381 134 µM -1.72018871651899 0.0712668468145565 no 3132 0.0426990717005118 989 5497911 SGTC_2997 9067075 71.4286 µM -1.72491113377224 0.0707295051007122 no 3133 0.0422717443921016 1027 27209819 SGTC_607 4491-0986 66.8 µM -1.72544872624136 0.0706685328770569 no 3134 0.0422233182702446 988 698981 YDR232W HEM1 SGTC_2473 5854593 8.94 µM -1.72711867373049 0.070479389743962 no 3135 0.0420731762794359 1045 2872951 SGTC_2218 6965428 192.983 µM -1.72900740606027 0.0702659356594199 no 3136 0.0419038847956912 1031 675684 SGTC_774 k060-0086 136 µM -1.72974420047169 0.0701828021570432 no 3137 0.0418379939132595 1050 5911235 SGTC_2628 lathosterol 100 µM -1.73927099189522 0.0691146830574997 no 3138 0.0409935536310834 1044 6710616 SGTC_271 rotenone 740 µM -1.7444526267415 0.0685390147441578 no 3139 0.040540097580234 1057 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3188 9110789 49.47 µM -1.74974884934549 0.0679544453761984 no 3140 0.0400808302312035 1038 849217 SGTC_1740 st038286 13.222 µM -1.75061792606781 0.0678588900207213 no 3141 0.0400058726780143 1033 716786 SGTC_2799 7812892 81.82 µM -1.75160103871061 0.067750921492453 no 3142 0.0399212169270193 1025 20205235 SGTC_1089 terbinafine 2.25 µM -1.75191094544732 0.0677169140798726 no 3143 0.0398945610847137 1037 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_612 0302-0167 22.4 µM -1.75500489512146 0.0673781241215662 no 3144 0.0396292352274779 1050 235821 SGTC_1263 0774-1208 64.8 µM -1.76052640061514 0.0667767720498121 no 3145 0.0391592976267852 1047 906585 SGTC_3155 9099265 49.47 µM -1.76584358447108 0.0662016061596183 no 3146 0.0387110470568966 1045 25236499 SGTC_3197 9113331 49.47 µM -1.77064493240654 0.0656855424884276 no 3147 0.0383098825406323 1022 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.78354767921883 0.0643141648240242 no 3148 0.0372485969269541 1064 279621 SGTC_442 cape 100 µM -1.78837719902801 0.0638066167205366 no 3149 0.0368575861973166 1069 5281787 SGTC_1635 st007035 42.4 µM -1.79323786722726 0.0632989463946819 no 3150 0.036467448781213 1004 3716403 SGTC_746 1095-0025 46.6 µM -1.79412046700934 0.0632071019227206 no 3151 0.0363969714643507 1050 6749286 SGTC_1171 0368-0077 21.4 µM -1.81512394836569 0.0610519280455165 no 3152 0.0347524318228616 1056 3239779 SGTC_1511 0906-3109 28.5 µM -1.8244065161211 0.060117935250365 no 3153 0.0340453188105416 1053 2882180 SGTC_1236 0330-0013 258 µM -1.82772595793725 0.0597866686156943 no 3154 0.0337953451616929 1060 4617066 SGTC_3343 9148379 18.9835 µM -1.83369296932057 0.0591947830177137 no 3155 0.0333497914251102 1012 1955036 SGTC_1988 st071872 53.4 µM -1.83479366178633 0.0590861057838934 no 3156 0.0332681340541126 1061 16414116 SGTC_2225 6654152 15.4 µM -1.8347979650341 0.0590856812086421 no 3157 0.033267815131353 1041 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_259 usnic acid 108.925 µM -1.84018489574966 0.0585560595211363 no 3158 0.0328705483600934 1072 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1086 cerivastatin 2.18 µM -1.84113620905176 0.0584629185941017 no 3159 0.0328008003162219 1042 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2602 kawain 100 µM -1.84207782714258 0.0583708415093018 no 3160 0.0327318832998727 1039 5369129 SGTC_1104 tacrolimus 29.8 µM -1.85283055170796 0.0573274340014135 no 3161 0.0319533248642935 1044 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1962 st076595 64.5 µM -1.86587905833081 0.0560810260939549 no 3162 0.0310291440634558 1047 279619 SGTC_2083 5306046 65.942 µM -1.86598147480889 0.0560713283728913 no 3163 0.0310219786826609 1057 539837 SGTC_2027 5150920 200 µM -1.87064872755397 0.0556307923012664 no 3164 0.0306968929406931 1035 786715 SGTC_1955 wogonin 32.4 µM -1.87418657480862 0.0552986831670987 no 3165 0.030452356938955 1040 5281703 A flavanone. SGTC_2981 9013952 38.96 µM -1.87835972266506 0.0549089513058515 no 3166 0.0301659857757186 1041 2996344 SGTC_2504 purpurogallin 52.29 µM -1.87903990371247 0.0548456351806346 no 3167 0.0301195224163948 1067 5281571 An antioxidant. SGTC_376 3970-0862 59.1 µM -1.88058804428911 0.0547017383142547 no 3168 0.0300139896704135 1045 3135186 SGTC_294 k038-0071 157 µM -1.8822174926247 0.0545506066174925 no 3169 0.0299032457678807 1068 24152826 SGTC_3207 9114163 49.47 µM -1.88342844813403 0.0544385042590345 no 3170 0.0298211640379384 1053 849233 SGTC_977 1348-1378 135 µM -1.8846545331996 0.0543251870330236 no 3171 0.0297382472992525 1045 X977 SGTC_1898 st060199 18.6 µM -1.88511167176684 0.0542829851655914 no 3172 0.0297073812796506 1047 688866 SGTC_2196 6573537 42.6665 µM -1.89353968895042 0.0535095701380356 no 3173 0.0291430676813831 1075 2903087 SGTC_1710 st031758 61.5 µM -1.8941747046391 0.0534516520833921 no 3174 0.0291009122441021 1064 5394341 SGTC_2560 caryophyllene 100 µM -1.89611759118993 0.0532747551406259 no 3175 0.0289722484863439 1070 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1453 4237-0541 195 µM -1.8974523995397 0.0531534919693706 no 3176 0.0288841277390214 1031 739892 SGTC_2522 biochanin a 4.94 µM -1.89861758510981 0.0530478174794154 no 3177 0.0288073872974491 1051 5280373 A possible chelator. SGTC_1959 st077091 55.8 µM -1.90210135768699 0.052732856222079 no 3178 0.028578952507473 1051 821356 YKL052C ASK1 SGTC_546 peri-Naphthalide 147 µM -1.90403931505203 0.052558292508863 no 3179 0.0284525320498109 1052 223824 A penicillin ester. SGTC_659 k018-0002 107 µM -1.91367907386098 0.0516967849183539 no 3180 0.0278305872401838 1063 6797879 YHR007C ERG11 SGTC_810 3825-7150 143 µM -1.91487948449205 0.0515902944573118 no 3181 0.0277539373619103 1018 22330411 YGL099W LSG1 SGTC_2678 equilin 100 µM -1.92461635932906 0.050732951789175 no 3182 0.0271386856205418 1049 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_46 0329-0187a 2.197 µM -1.92697693371751 0.0505268188082027 no 3183 0.0269912523032854 1054 46494817 SGTC_2269 7935389 174.42 µM -1.92948276334956 0.0503087323167262 no 3184 0.0268354789398116 1053 97605 SGTC_2738 aclarubicin 5.55 µM -1.93612911552032 0.0497339218756776 no 3185 0.0264259446892431 1080 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2902 5787006 60.46 µM -1.9477534785133 0.0487411946623927 no 3186 0.0257222338719268 1049 591003 SGTC_770 0389-1121 67.2 µM -1.96191876313122 0.0475529510847757 no 3187 0.024885971479446 1075 6753108 SGTC_2090 5301565 104.445 µM -1.97075563691607 0.0468235065119511 no 3188 0.0243759166389458 1064 2056344 SGTC_1211 1056-0033 32.3 µM -1.97435756194268 0.0465287703644858 no 3189 0.0241705499779463 1050 6741922 SGTC_3042 9091578 49.47 µM -1.97480929766114 0.0464919113188426 no 3190 0.0241448967618924 1056 25236497 SGTC_1889 st059080 5.18 µM -1.97600388601829 0.0463945526802482 no 3191 0.0240771685391979 1059 176925 Isolated from Daphnopsis sellowiana. SGTC_2665 lovastatin 100 µM -1.97932829910901 0.0461244751915312 no 3192 0.0238895277116115 1069 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3090 9117696 49.47 µM -1.97949289376925 0.0461111362915829 no 3193 0.0238802694697918 1058 7923821 SGTC_937 3122-0005 46.7 µM -1.9865429895913 0.045542692850372 no 3194 0.0234865321646734 1058 759535 SGTC_370 0180-0345 38.7 µM -1.98835992572047 0.0453971116495387 no 3195 0.0233859487741115 1031 3989527 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.98879773435384 0.0453620884456189 no 3196 0.0233617664849225 1041 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1423 4048-0112 5.59 µM -1.99037322754818 0.0452362341295372 no 3197 0.0232749184191733 1066 X1423 SGTC_246 cycloheximide 667 µM -1.99193388455315 0.0451118420832832 no 3198 0.0231891562753975 1064 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_490 phenamil 164 µM -1.99325975336301 0.0450063802030761 no 3199 0.023116505513877 994 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3142 9086498 49.47 µM -1.99818375414229 0.0446164525518237 no 3200 0.022848371081898 1020 25236367 SGTC_110 0850-0284 111.64 µM -2.00802476148577 0.0438453060695842 no 3201 0.0223203302331356 1054 3906265 SGTC_694 1315-0438 43.2 µM -2.01227378844871 0.0435156903040668 no 3202 0.0220955419520696 1068 6793154 SGTC_269 exalamide 29 µM -2.01476071154302 0.0433236984758638 no 3203 0.0219648637385345 1074 3316 A derivative of salicylamide. SGTC_1176 0848-0131 83.3 µM -2.01556694819783 0.0432616035766202 no 3204 0.0219226394237482 1072 6769040 SGTC_1323 1348-1351 11.2 µM -2.0197269099024 0.0429423520231054 no 3205 0.0217058611039785 1068 6989654 SGTC_230 MPP+ 141.667 µM -2.01979556958214 0.0429370988264614 no 3206 0.021702298449674 1071 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2491 paeonol 100 µM -2.0314181628381 0.0420553033238655 no 3207 0.0211062967484608 1080 11092 Increases levels of cortical cytochrome oxidase. SGTC_1381 2324-0066 62.1 µM -2.03245098090074 0.0419776587221192 no 3208 0.0210540107362654 1070 10885928 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.03529377585114 0.0417645438818409 no 3209 0.0209106610387946 1070 688798 SGTC_2717 st081029 62.2815 µM -2.04479287756839 0.041058776178493 no 3210 0.0204376411273575 1075 5292846 SGTC_3248 9135562 49.47 µM -2.04557980257253 0.0410007453786782 no 3211 0.0203988651499214 1068 17650701 SGTC_1629 st005085 44.9 µM -2.04703842008201 0.0408933573892431 no 3212 0.0203271561963999 1053 24207091 SGTC_933 2914-0560 114 µM -2.04881732716804 0.0407626976248639 no 3213 0.0202399903958678 1065 463887 SGTC_1404 3909-7820 48.3 µM -2.05394644121667 0.0403878624876012 no 3214 0.0199904378770679 1028 23741373 SGTC_331 k048-0133 24.5 µM -2.06448863803267 0.0396262277263122 no 3215 0.0194857050362482 1071 6813582 SGTC_2223 6903751 107.57 µM -2.07280429145362 0.0390337281718274 no 3216 0.0190952484496868 1062 5598863 SGTC_2751 anetholtrithion 17.25 µM -2.07586823456882 0.0388172454895124 no 3217 0.0189530696728046 1071 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1143 3454-2408 5.08 µM -2.08349430339834 0.0382826701209755 no 3218 0.0186030952060028 1033 X1143 SGTC_2385 9074692 200 µM -2.08498018734942 0.0381792139694878 no 3219 0.0185355495027277 1073 17046906 SGTC_3063 1327-0034 4 µM -2.08931964598785 0.0378783795220378 no 3220 0.0183394795309411 1059 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2969 9091408 28.7 µM -2.09082172200406 0.0377746993342185 no 3221 0.018272024073355 1062 4286311 SGTC_402 epigallocatechin gallate 10 µM -2.09227928379169 0.0376743132689969 no 3222 0.0182067698791826 1050 65064 An antioxidant. SGTC_1796 st049173 110.4 µM -2.09298145888838 0.0376260304333145 no 3223 0.0181754048547951 1063 94134 SGTC_2055 5235184 200 µM -2.09443649281662 0.0375261404577856 no 3224 0.0181105574024135 1060 2836034 SGTC_2671 danthron 100 µM -2.09921440825337 0.0371996523954608 no 3225 0.0178990022268304 1071 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1158 4092-0494 91.8 µM -2.10455958520406 0.036837156397184 no 3226 0.017664831373607 1081 1148199 SGTC_456 gingerol 170 µM -2.10673325703301 0.0366905721390381 no 3227 0.0175703538632015 1072 442793 A herb. SGTC_1081 sertraline 6 µM -2.11226842535982 0.0363194545854989 no 3228 0.0173317162287522 1062 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2445 5742597 35.57 µM -2.13169613562831 0.0350411271452059 no 3229 0.0165159173578774 1062 1774255 SGTC_960 1222-0186 7.7 µM -2.13559154478508 0.0347893091218886 no 3230 0.0163563606022029 1069 3126296 SGTC_3345 9148410 3.559 µM -2.13861297343008 0.0345950142395527 no 3231 0.0162335129668539 1048 4903596 SGTC_3157 9099274 49.47 µM -2.14050066583246 0.0344740780013612 no 3232 0.0161571635253464 1057 17217662 SGTC_68 0986-0284 82.829 µM -2.14083383573966 0.0344527693595987 no 3233 0.0161437201568515 1047 423278 YIL048W NEO1 SGTC_423 5-fluorouracil 457 µM -2.1412866082411 0.0344238286082888 no 3234 0.0161254662002734 1049 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1010 4112-3296 15.2 µM -2.14238028418009 0.0343540043643702 no 3235 0.0160814465508342 1061 704384 SGTC_298 1391-0729 10 µM -2.1429291402392 0.0343190072857659 no 3236 0.0160593943342171 1076 3237558 SGTC_2277 7947813 106.88 µM -2.14560688792826 0.034148684206196 no 3237 0.0159521777232984 1071 1246798 SGTC_699 0375-0592 111 µM -2.1461548238144 0.0341139175265352 no 3238 0.0159303142475147 1072 762578 SGTC_3009 9080819 71.4286 µM -2.15121892892915 0.0337939741266998 no 3239 0.0157294618282048 1076 17027216 SGTC_3108 9121785 49.47 µM -2.16929437000062 0.0326720633535316 no 3240 0.0150301711985702 1016 17140271 SGTC_450 aminopyrene 156 nM -2.17054389500239 0.0325956561719763 no 3241 0.0149828335492901 1070 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_135 0933-0004 26.348 µM -2.17175399346049 0.0325218004142381 no 3242 0.0149371117665838 1047 21230617 YGL099W LSG1 SGTC_3287 9117173 37.0625 µM -2.17338035100644 0.0324227566626335 no 3243 0.0148758512228782 1042 2789709 SGTC_1744 st037937 38.9 µM -2.17676200814853 0.0322176133146685 no 3244 0.0147491645274362 1063 1016152 SGTC_1047 2043-3044 82 µM -2.17994496947033 0.0320255034900489 no 3245 0.0146307704899166 1073 669592 SGTC_525 k781-2675 26.7 µM -2.18124834808313 0.0319471106176987 no 3246 0.0145825262739897 1048 3651118 YDL195W SEC31 SGTC_3088 9117578 49.47 µM -2.19598655246728 0.0310716462691432 no 3247 0.0140464529578201 1081 678341 SGTC_3153 9100258 49.47 µM -2.19608830703798 0.0310656716444611 no 3248 0.0140428116787375 1056 25236848 SGTC_2362 9071156 126 µM -2.20275988104402 0.0306760125361566 no 3249 0.0138058386089921 1079 653133 SGTC_1407 3909-7909 12.3 µM -2.21513000820483 0.0299642337622575 no 3250 0.0133755711288956 1053 4411780 SGTC_3204 9114183 49.47 µM -2.22195393700341 0.0295774814709311 no 3251 0.0131432093638348 1060 17027248 SGTC_1510 1123-0200 71.5 µM -2.2222185778576 0.0295625665602496 no 3252 0.0131342687750184 1078 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2657 nystatin 74.44 µM -2.22403025930654 0.0294606294563146 no 3253 0.0130732042198508 1065 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_720 r052-1644 49.9 µM -2.22505380858616 0.0294031669678539 no 3254 0.0130388130596364 1076 1422863 YOR257W CDC31 SGTC_2488 5268135 45.7 µM -2.22516578611215 0.0293968861534791 no 3255 0.0130350553754714 1063 1270356 YLR208W SEC13 SGTC_2155 5570423 76 µM -2.22654362754373 0.0293196942340117 no 3256 0.0129888950549827 1076 797402 SGTC_610 4215-0184 155 µM -2.22708810870672 0.0292892367651491 no 3257 0.0129706928924565 1048 5605015 SGTC_3060 1327-0027 12.5 µM -2.2283239873839 0.0292202010484343 no 3258 0.0129294589370893 1065 16000455 YPR107C YTH1 SGTC_1980 st071811 45.7 µM -2.22861106739332 0.029204184226587 no 3259 0.0129198970158294 1076 4974850 SGTC_1167 k781-0610 148 µM -2.23317353059924 0.0289506118583332 no 3260 0.0127687515648623 1071 4525169 SGTC_2396 5342950 42.78 µM -2.23445239935468 0.0288798641878215 no 3261 0.01272666061547 1041 1886677 SGTC_3319 9138450 16.7555 µM -2.23742010679723 0.0287162426653541 no 3262 0.012629447804838 1059 2029690 SGTC_2676 harmalol 100 µM -2.25027826460862 0.0280162010391636 no 3263 0.0122156433976299 1072 5459187 A monoamine oxidase inhibitor SGTC_1406 3909-7906 11.9 µM -2.26701754571291 0.0271262072603115 no 3264 0.0116945769513434 1040 X1406 SGTC_2612 dictamnine 15.46 µM -2.27824138984696 0.0265427689456095 no 3265 0.0113560997583113 1046 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2534 helenine 20.12 µM -2.2863041908805 0.0261301502222207 no 3266 0.0111182344409395 1063 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_673 1082-0474 110 µM -2.28659594494758 0.0261153206609258 no 3267 0.0111097090767996 1061 3098046 SGTC_2454 5-benzylidenerhodanine 10.36 µM -2.28831837782861 0.0260279145197212 no 3268 0.0110594935190754 1079 1273210 SGTC_1315 1237-0019 3.69 µM -2.28915473041055 0.0259855615176324 no 3269 0.011035181900758 1063 825140 SGTC_1162 k048-0130 20.1 µM -2.29181221452664 0.0258513686277257 no 3270 0.0109582407710128 1072 6797406 SGTC_1405 3909-7894 12 µM -2.29404842521267 0.0257388981825088 no 3271 0.0108938586685536 1044 7104060 SGTC_106 0092-0003 11.579 µM -2.29836975063992 0.0255227169460233 no 3272 0.0107703768225314 1077 1072148 SGTC_1883 5-benzylidenerhodanine 20 µM -2.30144264816397 0.0253699170680083 no 3273 0.0106833118103664 1062 1273210 SGTC_2743 auranofin 4.32 µM -2.31905633631787 0.0245087886177434 no 3274 0.0101959909347209 1073 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1817 st052116 64.4 µM -2.32056584545736 0.0244361442641697 no 3275 0.0101551436668185 1080 4361398 SGTC_288 1315-0019 35.1 µM -2.32889209143486 0.0240386885897967 no 3276 0.00993239150500649 1060 6811474 SGTC_2275 7947463 200 µM -2.34798323320324 0.0231478357376871 no 3277 0.00943768548072131 1054 1225414 SGTC_2506 ethyl hematommate 54.16 µM -2.36237563038002 0.0224947622775304 no 3278 0.00907911651883083 1081 3940691 An allergen. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.37743846103826 0.0218279759459584 no 3279 0.00871667582841737 1074 4000243 SGTC_2102 5377816 72.7585 µM -2.40132390016258 0.020804891971743 no 3280 0.00816793486247624 1072 1379702 SGTC_2384 9036245 200 µM -2.41869747396484 0.0200864934038206 no 3281 0.0077880942348936 1076 6462766 SGTC_1229 0139-0193 12.2 µM -2.42463101624553 0.0198460105667054 no 3282 0.00766197643278472 1076 3090752 SGTC_2627 acetyl isogambogic acid 100 µM -2.42902031347246 0.0196696912593548 no 3283 0.00756984203133947 1073 6857789 A caspase activator and apoptosis inducer. SGTC_1827 berberine 7.24 µM -2.42912686586474 0.0196654276082499 no 3284 0.00756761760506641 1043 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2268 7933382 153.85 µM -2.43814799749871 0.0193072851134919 no 3285 0.00738136429159052 1073 935025 YOR257W CDC31 SGTC_1607 st000305 50.6 µM -2.44232799971646 0.019143225727582 no 3286 0.00729644074625404 1084 5457690 SGTC_2127 5253358 187.912 µM -2.45318556733664 0.0187226090660385 no 3287 0.00707986357323622 1082 20612 SGTC_1909 st060837 51.5 µM -2.47049596243846 0.018068285886265 no 3288 0.00674629210281785 1065 678937 SGTC_2324 6149169 200 µM -2.47734107851053 0.0178149763514306 no 3289 0.00661826708007953 1076 2888231 SGTC_1345 1488-0192 31.4 µM -2.48221709988034 0.0176363879488758 no 3290 0.00652838493837016 1081 658348 SGTC_533 1222-0222 6.71 µM -2.49646821374651 0.0171231629856937 no 3291 0.00627184551247463 1086 3982874 SGTC_1374 2889-5571 141 µM -2.51087417544088 0.0166173880162227 no 3292 0.00602163072387623 1078 2853281 SGTC_2781 5567276 71.43 µM -2.51257877532381 0.0165583961676279 no 3293 0.00599261717697705 1075 2853274 SGTC_1820 st053765 18.6 µM -2.51709813433102 0.0164028595728576 no 3294 0.00591629334606554 1083 3690829 SGTC_2682 pyrogallin 40.03 µM -2.51987510898717 0.016307910069465 no 3295 0.00586982398875969 1081 822798 An ATP competetive kinase inhibitor. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -2.52317065191983 0.0161958409848389 no 3296 0.00581509731208072 1079 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_551 k048-0028 34.9 µM -2.5509615817709 0.0152767446244551 no 3297 0.00537130834437024 1070 6836383 SGTC_2716 st080858 38.6235 µM -2.55146715345765 0.0152604481306643 no 3298 0.0053635217468227 1082 5296050 SGTC_779 1360-0071 233 µM -2.55433844039421 0.0151681785895596 no 3299 0.00531948948295265 1083 7566 SGTC_3105 9121040 49.47 µM -2.55638547956126 0.0151026894934795 no 3300 0.00528829395410416 1080 41448907 SGTC_2528 xanthyletin 44.79 µM -2.57162905108655 0.0146226134533478 no 3301 0.00506106412701012 1082 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.57532532092592 0.0145082022428342 no 3302 0.00500729219114917 1074 6708739 YPR165W RHO1 SGTC_2689 tacrolimus 100 µM -2.58580155906956 0.0141881073013705 no 3303 0.00485764230849446 1055 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3339 9145883 14.936 µM -2.59683783746379 0.0138575000316168 no 3304 0.00470431655876187 1059 2030670 SGTC_2462 5162487 171.77 µM -2.59912140755314 0.0137899282161933 no 3305 0.0046731355572783 1093 2259986 SGTC_1855 st056195 39.6 µM -2.60877676637791 0.0135073540043774 no 3306 0.0045433249065641 1062 4028379 SGTC_1378 2093-0007 380 nM -2.61535817445576 0.0133176193299908 no 3307 0.00445669650400998 1085 3618014 SGTC_367 0335-0881 7.1 µM -2.62577851108154 0.0130219204032798 no 3308 0.00432255256256722 1081 23828853 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -2.6281152273835 0.0129563957618698 no 3309 0.00429297133916681 1077 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_768 0384-0033 77.3 µM -2.65361893505863 0.0122595740339157 no 3310 0.00398168505547527 1079 3965305 YMR134W ERG29 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.65542643028149 0.0122114450236046 no 3311 0.00396041044714248 1080 3256 An antibiotic and ribosome inhibitor. SGTC_2486 5283202 22.39 µM -2.65880359121685 0.0121219584688197 no 3312 0.0039209331823187 1082 1377751 SGTC_2233 sulbentine 40.3845 µM -2.66061046367427 0.0120743145858665 no 3313 0.00389995686063408 1054 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_922 1866-0035 480 µM -2.67673529185044 0.0116562738313381 no 3314 0.0037171672525534 1071 3156169 SGTC_761 k216-0224 480 µM -2.68159802698346 0.0115326975352949 no 3315 0.00366357219240944 1091 1340404 SGTC_2718 lomofungin 53.02 µM -2.70804673826572 0.010880291460724 no 3316 0.00338402451706225 1081 5351222 A RNA synthesis inhibitor. SGTC_3107 9121808 49.47 µM -2.72399109237521 0.0105027128128031 no 3317 0.00322491230199179 1085 662681 SGTC_2148 5546263 113.568 µM -2.72640931588156 0.0104464555439193 no 3318 0.00320137719036813 1091 792097 SGTC_1133 3473-0247 50 µM -2.72689222877236 0.0104352526284528 no 3319 0.0031966958447246 1068 711311 SGTC_329 k048-0121 21.3 µM -2.74608157404424 0.00999847967403325 no 3320 0.00301558826769963 1093 6832902 SGTC_2147 5545932 89.7195 µM -2.76763899883333 0.0095269170594047 no 3321 0.00282319808356243 1094 797404 SGTC_941 3237-0776 460 µM -2.76810575004841 0.00951692580049594 no 3322 0.00281915786345565 1086 760008 SGTC_444 curcumin 90.4 µM -2.80668552801412 0.0087221259022341 no 3323 0.0025027039774083 1081 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1389 3405-0187 19 µM -2.82963083256168 0.00827754565978558 no 3324 0.0023300870961244 1087 799890 SGTC_3089 9117425 49.47 µM -2.84238035545836 0.0080392195560309 no 3325 0.00223890172931314 1087 9401657 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.88710658839066 0.00725017751903128 no 3326 0.00194401246247033 1078 279621 SGTC_150 3970-0969 77.2 µM -2.90054908346483 0.00702677420384251 no 3327 0.00186254746427677 1087 6615640 SGTC_3059 1327-0034 3 µM -2.91559606057842 0.00678393196749365 no 3328 0.00177504900687465 1085 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3242 9133940 49.47 µM -2.94634746860766 0.00631058364779291 no 3329 0.00160775482376636 1092 17248444 SGTC_513 4245-1575 41.7 µM -2.96783841419507 0.00599737127117776 no 3330 0.00149950971823936 1082 719745 SGTC_2401 5128683 200 µM -3.00789583168296 0.00545016003352428 no 3331 0.00131531645637364 1091 708373 SGTC_145 3737-0113 38.366 µM -3.00982491460507 0.00542496490620072 no 3332 0.00130699162864794 1089 6849351 SGTC_1636 st007707 68.9 µM -3.01797600913893 0.00531964530447313 no 3333 0.00127234524529551 1088 403051 SGTC_2701 st077767 14.721 µM -3.0297943796174 0.00517017042789451 no 3334 0.00122360142398832 1080 5721188 SGTC_676 falcarinol 140 µM -3.03282538066031 0.00513244264731607 no 3335 0.0012113787466098 1081 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2986 9022445 71.43 µM -3.06005415677597 0.00480435516019834 no 3336 0.00110648485746049 1086 6459286 SGTC_1383 3049-0032 20.7 µM -3.0716175317464 0.00467077566112509 no 3337 0.00106451164561578 1087 712864 SGTC_3222 9128301 49.47 µM -3.08026703372236 0.00457303380330041 no 3338 0.00103407539346953 1072 4911358 SGTC_1174 0739-0097 51.1 µM -3.09622205082751 0.00439751680180242 no 3339 0.000980017614740293 1092 728447 SGTC_2139 5578692 56.4705 µM -3.10939990684723 0.00425711576125918 no 3340 0.000937338954673617 1077 650991 YMR113W FOL3 SGTC_3210 9128157 49.47 µM -3.13578689074676 0.00398797025457962 no 3341 0.000856968496138553 1078 17590849 SGTC_1074 carmofur 3.8 µM -3.14329496143771 0.00391422531486592 no 3342 0.000835287037188516 1094 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2499 avocadenofuran 51.48 µM -3.21013932613962 0.00330964165789698 no 3343 0.000663353244681558 1092 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1919 st067113 52.3 µM -3.21457140844066 0.00327269405120902 no 3344 0.000653197084971372 1085 1268243 SGTC_2739 tacrine 100.86 µM -3.21984489461602 0.0032292157297441 no 3345 0.000641299861008371 1026 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_683 panaxydol 45 µM -3.25628250615801 0.00294272950843736 no 3346 0.000564406877043397 1094 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2904 7225135 42.03 µM -3.2901128228003 0.00269746944100704 no 3347 0.000500736095669328 1089 4446116 SGTC_1455 4262-0120 131 µM -3.2964324313951 0.00265375509063698 no 3348 0.000489605829202886 1094 1529587 SGTC_1731 st035964 63 µM -3.47265050962265 0.0016652022386386 no 3349 0.000257672980844653 1089 6739575 SGTC_2679 rapamycin 1 nM -3.54787972951701 0.00135640382353652 no 3350 0.000194172754093403 1069 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1880 MG-132 525 µM -3.62969243569152 0.0010806708055713 no 3351 0.000141879560956539 1084 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -3.74659262860348 0.000775116181665958 yes 3352 8.96264157794998e-05 1092 6708561 SGTC_3189 9110682 49.47 µM -3.87852789363775 0.000526982538945191 yes 3353 5.25452391887158e-05 1091 17122418 SGTC_2913 7966556 36.57 µM -3.99880115218515 0.000367027701998273 yes 3354 3.18320691751805e-05 1086 2976516 SGTC_280 3448-3607 3.04 µM -4.24573208002381 0.000169490879642191 yes 3355 1.08940427424218e-05 1089 626179 SGTC_2552 juarezic acid 87.02 µM -4.67244689673838 4.05314116052031e-05 yes 3356 1.48816241604615e-06 1091 1549512