SGTCid condition conc unit UPC2|YDR213W.score UPC2|YDR213W.strain.pval UPC2|YDR213W.strain.significant UPC2|YDR213W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_178 4092-0806 87.505 µM 10.095533986786 1.04502714788769e-23 yes 1 2.89077736197136e-24 9 2169044 SGTC_1019 4262-0212 3.4 µM 8.48351632753482 2.8187109121073e-17 yes 2 1.09244270941387e-17 12 4677213 SGTC_2021 4019055 173 µM 8.39966630446346 5.68390469300526e-17 yes 3 2.23874592072572e-17 19 44827708 YER133W GLC7 SGTC_207 4185-0010 4.486 µM 7.80579185682243 6.72183974935492e-15 yes 4 2.95645490853739e-15 27 3761753 SGTC_346 4513-0042 7.16 µM 7.32386038210395 2.51721335572611e-13 yes 5 1.20468681114327e-13 4 2827372 SGTC_278 4092-0821 23.9 µM 7.07610148248586 1.48586911772978e-12 yes 6 7.41331515932548e-13 11 877900 SGTC_658 3253-0951 102 µM 6.99589516605422 2.60672667092006e-12 yes 7 1.31785285303567e-12 10 1184878 SGTC_2703 st077852 53.4 µM 6.19225424733064 5.17443782827249e-10 yes 8 2.96548896910785e-10 3 6281836 SGTC_3018 9082602 49.47 µM 6.04799703507742 1.25271506908524e-09 yes 9 7.33288274927272e-10 27 17332089 SGTC_299 1273-0059 1.44 µM 5.93917576872044 2.40877214609468e-09 yes 10 1.43229305981986e-09 7 2848077 SGTC_363 0455-0021 3.06 µM 5.89258021199725 3.1759421425496e-09 yes 11 1.90105715140964e-09 34 4597466 SGTC_3037 9091026 49.47 µM 5.71422491969182 8.97786904732204e-09 yes 12 5.51025792302928e-09 55 25236398 YIL048W NEO1 SGTC_2776 terbinafine 19.92 µM 5.60079352756926 1.71133706610321e-08 yes 13 1.06686383110517e-08 24 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_40 0327-0103 19.753 µM 5.56330840334908 2.11226428987061e-08 yes 14 1.32353733959566e-08 8 409036 SGTC_2801 7907800 81.82 µM 5.55882506972279 2.16592071206013e-08 yes 15 1.35798367206072e-08 7 6620925 SGTC_2250 alverine citrate 130 µM 5.5274843399824 2.57968584843015e-08 yes 16 1.62427606996737e-08 72 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2570 licareol 100 µM 4.93247999821107 5.97093340060442e-07 yes 17 4.05960480149782e-07 12 443158 SGTC_310 1273-0058 1.06 µM 4.92577673208859 6.17423710039717e-07 yes 18 4.20129491903137e-07 187 2734232 SGTC_2249 haloperidol 116.36 µM 4.90988252455866 6.68325484549145e-07 yes 19 4.55654846915249e-07 67 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3152 9099253 49.47 µM 4.88448347483623 7.58143554322675e-07 yes 20 5.18501694856161e-07 82 25236131 SGTC_201 4262-0159 12.803 µM 4.79865368135703 1.15571270841328e-06 yes 21 7.98678590707217e-07 28 1341029 SGTC_2598 perillyl alcohol 100 µM 4.63776755235359 2.49988524262417e-06 yes 22 1.7609627491389e-06 16 10819 An apoptosis inducer. SGTC_2449 5812982 45.77 µM 4.51547393630152 4.42101128456862e-06 yes 23 3.15876583779649e-06 4 776185 SGTC_2850 9015429 58.44 µM 4.3884165466624 7.87573331819663e-06 yes 24 5.7089465626848e-06 6 6457570 SGTC_2006 4011487 200 µM 4.35162836849896 9.28256913203499e-06 yes 25 6.75650837204199e-06 70 45595294 SGTC_1579 chlormadinone acetate 49.4 µM 4.2419808936218 1.50361030776267e-05 yes 26 1.10777778745932e-05 7 45114258 A steroidal progestin. SGTC_2896 9052656 71.43 µM 4.23087819362764 1.57787456473318e-05 yes 27 1.16390353458666e-05 94 6469436 SGTC_2715 st079500 56.4 µM 4.18518652926022 1.9218015856843e-05 yes 28 1.42466013968149e-05 6 28246688 SGTC_3 0833-0587 95.581 µM 4.09257232005813 2.84894003649429e-05 yes 29 2.13307063993659e-05 19 5382644 SGTC_218 alverine citrate 93.75 µM 3.93896781579336 5.37744552988e-05 yes 30 4.09164527504614e-05 33 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1005 4092-0690 4.4 µM 3.92288525160477 5.73996615724533e-05 yes 31 4.3747414513112e-05 31 1529343 SGTC_2532 xanthone 78.9 µM 3.9076447866553 6.10467391977702e-05 yes 32 4.66000959082661e-05 32 7020 An insecticide. SGTC_312 4092-0653 6.84 µM 3.88042076067847 6.81110702167959e-05 yes 33 5.21379570229512e-05 87 1148278 SGTC_1436 4092-1007 8.32 µM 3.78074523439374 0.000101105708251238 yes 34 7.81798079260043e-05 16 2881121 SGTC_457 grayanotoxin iii 135 µM 3.77935451334066 0.000101657857970802 yes 35 7.86177150871594e-05 79 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_320 4092-0846 5.34 µM 3.74639102535126 0.000115604675255125 yes 36 8.96984411144335e-05 56 1359356 SGTC_2549 cedrol 20.94 µM 3.74336749417835 0.000116970081684339 yes 37 9.07851858889423e-05 18 6708665 A sedative which affects the nervous system. SGTC_3239 9133757 49.47 µM 3.6915948312058 0.000142830588178671 yes 38 0.000111426137714545 5 17036923 SGTC_768 0384-0033 77.3 µM 3.68935078546229 0.00014406442883973 yes 39 0.000112413522947638 94 3965305 YMR134W ERG29 SGTC_2525 harmine 47.85 µM 3.63426996990085 0.000177668791433723 yes 40 0.00013938442272315 13 5280953 A monoamine oxidase inhibitor SGTC_2887 9044784 58.44 µM 3.62392988219263 0.000184743136228642 yes 41 0.000145080149340482 44 6465546 SGTC_1531 st059297 52.4 µM 3.58677533862651 0.000212395326646748 yes 42 0.00016739626500162 32 7566702 SGTC_1072 oxiconazole 14.9 nM 3.54228791284168 0.000250580659338345 yes 43 0.000198336130528018 64 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2777 climbazole 1.536 µM 3.47302964488685 0.000322960776268677 yes 44 0.000257309254876282 72 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_436 n,n-dimethylsphingosine 3.3 µM 3.45539071586388 0.000344278019494341 yes 45 0.000274747950091985 44 5282309 SGTC_2721 ifenprodil 61.44 µM 3.43557728693454 0.000369779128024779 yes 46 0.000295646389674251 39 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2607 solasodine 47.35 µM 3.36802613336832 0.00047050582823502 yes 47 0.000378542097227692 84 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_193 1273-0060 1.558 µM 3.36622028320644 0.000473518399821032 yes 48 0.000381029129858394 19 2847393 YHR072W ERG7 SGTC_2398 5228213 48.84 µM 3.32619376147254 0.0005450551100429 yes 49 0.000440203520871702 75 80771 YMR134W ERG29 SGTC_1913 st060213 96.1 µM 3.26560869511483 0.00067253097741816 yes 50 0.000546145377141586 67 688959 SGTC_954 1189-0853 2.85 µM 3.16565553740508 0.00094427395748218 yes 51 0.000773669559281156 74 2828194 SGTC_2057 5236571 38.335 µM 3.15983050105882 0.000962863772470516 yes 52 0.00078930473157044 73 54684039 YBR257W POP4 SGTC_1611 st001856 99.4 µM 3.15421124896109 0.000981114744231782 yes 53 0.000804662734731797 52 647478 SGTC_689 0833-0039 98 µM 3.1279207293516 0.00107079791575345 no 54 0.000880238275688509 55 5374726 SGTC_2451 5856223 45.7 µM 3.12508894357262 0.00108089339738785 no 55 0.000888756526036043 46 2179896 SGTC_2409 alverine citrate 63.97 µM 3.11856137771091 0.00110449779996499 no 56 0.000908681426266557 96 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2880 9042983 58.44 µM 3.10937653484809 0.00113851172430038 no 57 0.000937413113409865 63 6464714 SGTC_1780 st038448 24.544 µM 3.1059519183887 0.00115143768688425 no 58 0.000948337766497901 62 728868 YDL195W SEC31 SGTC_2165 5727197 32.143 µM 3.10083625969532 0.0011709968717817 no 59 0.00096487484247703 79 1361712 SGTC_2434 5670830 169.91 µM 3.08965266433943 0.00121482004156628 no 60 0.00100195345515867 65 1549830 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 3.07788263064117 0.00126255803919611 no 61 0.0010423850365412 64 5355888 SGTC_2619 obliquin 87.91 µM 3.07037414279422 0.00129390175122172 no 62 0.00106895384784146 213 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2713 st079149 53.4 µM 3.06974226589155 0.0012965716728683 no 63 0.00107121783506919 57 3103253 SGTC_2397 5161689 200 µM 3.06882512864018 0.00130045589106832 no 64 0.00107451171997355 79 2259942 SGTC_2068 5226020 147 µM 3.0459175850818 0.0014009914123322 no 65 0.00115985704840409 68 1810509 SGTC_1317 1273-0028 910 nM 3.02615092612119 0.00149339371185535 no 66 0.00123844317265151 92 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_489 paxilline 115 µM 3.02532156957391 0.00149738952185013 no 67 0.00124184452103248 57 105008 A toxic potassium channel blocker. SGTC_1951 sophoraflavanone G 9.2 µM 3.00652371620585 0.00159061345117459 no 68 0.00132126719741898 78 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1928 4'-methoxychalcone 40.3 µM 3.00650222599038 0.00159072298924207 no 69 0.00132136059396467 41 641818 SGTC_1172 0370-0043 85 µM 3.00390746760987 0.00160399940869345 no 70 0.00133268187594872 63 376585 SGTC_1032 k061-1018 98.7 µM 2.99564872616257 0.00164693130631094 no 71 0.00136930857185602 69 4005393 SGTC_835 0312-0010 67.2 µM 2.991183753095 0.00167057529814747 no 72 0.00138949107703485 42 1626196 SGTC_515 4092-1064 102 µM 2.98007332528661 0.00173075748581926 no 73 0.00144089696267044 114 717353 SGTC_217 ketoconazole 989 nM 2.96793050244586 0.00179878342971774 no 74 0.00149906055111436 71 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_252 miconazole 1.30953 nM 2.94706785470114 0.00192135989336354 no 75 0.00160401399971955 86 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2627 acetyl isogambogic acid 100 µM 2.8968270616988 0.00224827989477459 no 76 0.0018847874483602 105 6857789 A caspase activator and apoptosis inducer. SGTC_2813 7971799 71.43 µM 2.89113751325377 0.00228831497474942 no 77 0.00191925060530359 75 2234054 SGTC_2925 9010536 32.5 µM 2.86818731072336 0.00245644438007146 no 78 0.00206415522583791 112 2994177 SGTC_1066 ketoconazole 628 nM 2.82481663787047 0.0028049817242146 no 79 0.00236538400016151 74 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1937 st074714 47.2 µM 2.81202550194765 0.00291597354379589 no 80 0.00246152999747627 100 17250970 SGTC_2974 9094440 9.66 µM 2.7832614483278 0.00318015737623189 no 81 0.00269077103888804 119 25236134 SGTC_2075 5212009 200 µM 2.77852560504135 0.00322566206150074 no 82 0.00273031047047358 59 780898 SGTC_2601 securinine 100 µM 2.77803446329119 0.00323041459818348 no 83 0.00273444087083954 85 442872 A GABA receptor antagonist. SGTC_609 0986-0026 86.3 µM 2.75693573159372 0.00344061974342766 no 84 0.0029172908990591 105 2848610 SGTC_649 1123-0311 367 µM 2.75621841273389 0.00344797756136933 no 85 0.00292369682497596 153 693629 YIL048W NEO1 SGTC_917 harmaline 728.087 nM 2.75427576849622 0.00346797504860753 no 86 0.00294110908524382 95 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2568 diosmetin 100 µM 2.72440720868352 0.0037888331545844 no 87 0.00322085143776086 94 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1253 0550-0034 176 µM 2.69718217051256 0.00410421431876348 no 88 0.00349645016948595 91 5969915 SGTC_3028 9087778 49.47 µM 2.68715669283801 0.00422614362675568 no 89 0.00360315691830134 74 17217395 SGTC_1308 1187-1617 41.4 µM 2.68060832218849 0.00430752355982799 no 90 0.00367442377917245 129 2882570 SGTC_2561 acetosyringone 100 µM 2.66469968780859 0.00451109245906365 no 91 0.00385285510775763 123 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_921 1561-0023 372 µM 2.66328582609658 0.00452959357370898 no 92 0.00386908270477671 94 24050882 SGTC_3209 9113616 49.47 µM 2.65634057483662 0.00462146313836861 no 93 0.00394968958256208 115 16649353 SGTC_2145 5634607 200 µM 2.63083616141179 0.00497325680103668 no 94 0.0042587543400574 61 308662 SGTC_2078 5212016 200 µM 2.62232601511842 0.00509584057940375 no 95 0.00436659228310604 67 1899708 SGTC_3281 9140613 49.47 µM 2.61569671322041 0.00519318821822912 no 96 0.00445228061932936 91 16013766 SGTC_1128 3448-9350 235 µM 2.59778390842433 0.00546455453264793 no 97 0.0046913759883018 108 619386 SGTC_1962 st076595 64.5 µM 2.59205817797979 0.00555391484958178 no 98 0.00477018182764903 124 279619 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.58808778182103 0.00561663983070843 no 99 0.00482551913698169 151 676296 Flavone; oxidizing agent. SGTC_463 ikarugamyin 104 µM 2.58523636473149 0.00566207433015089 no 100 0.00486561304600602 28 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_811 0416-0114 265 µM 2.58361629114039 0.00568803370579018 no 101 0.00488852501000303 114 6612453 SGTC_1999 st074831 12.5 µM 2.58226960700952 0.00570969276514558 no 102 0.0049076436811963 117 17112523 SGTC_425 3825-7017 13.1 µM 2.57817918758835 0.0057759295745796 no 103 0.00496612393950493 129 3397440 SGTC_2244 6635614 200 µM 2.55438699239997 0.00617488917101257 no 104 0.00531874769174668 49 836499 SGTC_507 nimesulide 162 µM 2.55171933246146 0.00622110976863929 no 105 0.00535964154716471 110 4495 A COX2 inhibitor. SGTC_1552 6-methylflavone 10.6 µM 2.54564938041149 0.00632742288078215 no 106 0.00545373419516883 71 689013 SGTC_2620 irigenin 100 µM 2.54548803504593 0.00633027059925679 no 107 0.00545625517751379 131 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2683 piperine 63.03 µM 2.54186915545152 0.00639444200568868 no 108 0.00551307207693312 83 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_734 2023-0417 80 µM 2.54014093064149 0.00642529017599648 no 109 0.00554039043330412 120 3935732 SGTC_327 1273-0057 3.96 µM 2.5167602978795 0.00685575412342869 no 110 0.0059219688369544 107 3108138 SGTC_222 nsc-310342 10.666 µM 2.51387125530272 0.00691067469679646 no 111 0.00597070089205815 43 432556 SGTC_2593 nobiletin 86.24 µM 2.50930289323655 0.00699831207375193 no 112 0.0060484853215724 117 72344 An anti-infammatory. SGTC_983 1491-0821 12.2 µM 2.48179486631671 0.00754704518446097 no 113 0.0065361252603352 86 46495113 SGTC_3255 9139072 49.47 µM 2.4631750820396 0.00793965602996214 no 114 0.00688563251514744 105 17646060 SGTC_651 3253-0966 34.4 µM 2.43847962378748 0.00848802394730665 no 115 0.00737459509052781 138 781462 SGTC_3146 9095609 49.47 µM 2.42968171339683 0.00869126367885779 no 116 0.00755604370825585 114 17173999 SGTC_356 1634-0012 32.5 µM 2.40751691552906 0.00922231744637667 no 117 0.00803070906294566 134 735457 SGTC_8 0354-0001 70 µM 2.37249517623579 0.0101193436609196 no 118 0.00883419692063741 231 4993152 SGTC_1559 coumarin 343 70.1 µM 2.36878811856849 0.0102186093238029 no 119 0.0089232370323237 111 108770 A hepatotoxic, DNA x-linker. SGTC_2689 tacrolimus 100 µM 2.36282126434787 0.0103801706367059 no 120 0.00906820713077424 166 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_167 3672-0051 66.205 µM 2.35116926208176 0.0107020952068993 no 121 0.00935725930743337 173 3237971 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.35116402849672 0.0107022417334089 no 122 0.0093573909276947 132 688669 SGTC_475 α-linolenic acid 10 µM 2.34562346046984 0.0108583461774617 no 123 0.00949764322980595 144 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1855 st056195 39.6 µM 2.34007671371444 0.0110166060532977 no 124 0.00963988963770954 129 4028379 SGTC_254 nsc-64875 3.808 µM 2.32897565323628 0.0113393773137526 no 125 0.00993017776925865 131 56993 SGTC_1819 st053448 58.6 µM 2.32520558927678 0.0114508485572883 no 126 0.0100304848158435 140 2857616 SGTC_2421 5690543 90.72 µM 2.32413692889601 0.0114826187910052 no 127 0.0100590781782567 144 3397993 SGTC_1310 1188-0297 994 nM 2.30797137013275 0.0119726263793178 no 128 0.0105003644594451 154 1588352 SGTC_706 4262-0057 46.9 µM 2.29292987460837 0.01244474645105 no 129 0.0109260212744908 168 883298 SGTC_733 4069-0007 56.1 µM 2.28794008668412 0.0126048866345264 no 130 0.0110705052144404 251 5717425 YNL287W SEC21 SGTC_155 k072-0202 43.6 µM 2.28069165358675 0.0128406911120776 no 131 0.0112833497040962 121 5857737 SGTC_2048 5246248 200 µM 2.27836931305304 0.0129170437074874 no 132 0.0113522915684896 98 677046 SGTC_1216 1165-0504 9.65 µM 2.26692932587848 0.0132989177321837 no 133 0.0116972717109664 143 6304004 SGTC_1560 lithocholic acid 53.1 µM 2.24362267965587 0.014107167654604 no 134 0.0124283443822197 73 9903 A bile acid which acts as a detergent. SGTC_1510 1123-0200 71.5 µM 2.23012716973261 0.0145942606623538 no 135 0.0128695007750961 218 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_912 3474-0017 2.18 µM 2.22949434014016 0.014617452316055 no 136 0.01289051573817 166 3360550 SGTC_960 1222-0186 7.7 µM 2.22670916570401 0.0147198994234864 no 137 0.0129833587314389 172 3126296 SGTC_2290 7904846 200 µM 2.22349162349757 0.0148390186684152 no 138 0.0130913337990749 199 2962154 SGTC_2043 5101342 149 µM 2.22191265874206 0.0148977773918358 no 139 0.0131446043767574 172 678451 SGTC_715 0868-0130 184 µM 2.22132308064589 0.0149197688628724 no 140 0.0131645433392992 120 2876258 SGTC_182 3448-4371 550.524 µM 2.21025876647871 0.0153376778310248 no 141 0.0135436042738036 162 3491403 SGTC_1456 k015-0012 13 µM 2.20347397606852 0.0155988859838549 no 142 0.0137806796139273 192 2989616 SGTC_3154 9100113 49.47 µM 2.20086602771564 0.0157003004348818 no 143 0.0138727547848449 176 25237525 SGTC_1268 0828-0275 2.46 µM 2.19401958007612 0.0159692314693664 no 144 0.0141170009793293 178 745337 SGTC_2621 lithochol-11-enic acid 100 µM 2.18875862542615 0.0161785579373894 no 145 0.0143071942051561 217 6708711 SGTC_646 4092-0839 27.3 µM 2.1812027960374 0.0164833046411046 no 146 0.0145842100594407 146 877796 SGTC_417 st075190 100 µM 2.17860792097597 0.0165890903095361 no 147 0.014680403626214 167 222757 SGTC_2074 5212007 75.395 µM 2.17716120555674 0.0166483206530146 no 148 0.0147342708524582 138 758611 SGTC_1455 4262-0120 131 µM 2.17672753877339 0.0166661107290178 no 149 0.0147504511541148 197 1529587 SGTC_2698 st077697 67.5 µM 2.17579398363836 0.016704462655198 no 150 0.0147853343833492 155 3154499 SGTC_2732 terfenadine 20 µM 2.16917161540328 0.0169786936583813 no 151 0.0150348286239396 123 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1143 3454-2408 5.08 µM 2.16607792544504 0.0171081160878664 no 152 0.015152616363547 105 X1143 SGTC_999 SEC7.066 22.7 µM 2.15531496233557 0.017564966501914 no 153 0.0155685978644898 199 740511 YDR170C SEC7 SGTC_2516 gossypol 71.55 µM 2.15244795740559 0.017688403070275 no 154 0.0156810450025199 186 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_626 0214-0009 33 µM 2.14954673901991 0.0178140654252122 no 155 0.01579554261871 171 3437874 SGTC_1365 1672-3266 55.4 µM 2.14154093805217 0.0181647827573539 no 156 0.0161152204102062 177 6415873 SGTC_1175 0741-0056 27.6 µM 2.14048965669519 0.0182112714233736 no 157 0.0161576079064638 198 765927 SGTC_1011 4112-3381 17.4 µM 2.12857515462644 0.0187452664709689 no 158 0.0166447129543534 211 2877139 SGTC_1700 st030840 7.9285 µM 2.12625662961066 0.018850714515242 no 159 0.0167409485744996 181 5499307 SGTC_442 cape 100 µM 2.12160087658834 0.0190639860216291 no 160 0.016935634360818 145 5281787 SGTC_1846 st056244 14.8 µM 2.11432919756759 0.0194011918283295 no 161 0.0172435801299974 222 5393182 SGTC_3138 9097216 49.47 µM 2.11121713499735 0.019547046881335 no 162 0.0173768263413088 173 25237486 SGTC_2306 7482397 179.52 µM 2.10935879805481 0.0196345860515356 no 163 0.017456811536921 188 891448 SGTC_2765 myclobutanil 7.74 µM 2.1073759874033 0.0197283555509154 no 164 0.0175425006804721 218 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1484 3473-2379 286 µM 2.09844685259332 0.0201553493563057 no 165 0.0179328450697166 196 671917 SGTC_843 0310-0051 143 µM 2.0977304603179 0.0201899445084079 no 166 0.0179644812503379 175 2065037 SGTC_2836 9010338 19.48 µM 2.09734359674364 0.0202086473854193 no 167 0.017981585087 206 2994051 SGTC_298 1391-0729 10 µM 2.09470157848158 0.0203367686046297 no 168 0.0180987644182535 170 3237558 SGTC_2885 9057732 51.95 µM 2.09445796375979 0.0203486169759148 no 169 0.018109601971277 187 6471414 SGTC_1511 0906-3109 28.5 µM 2.09408209742843 0.0203669089736229 no 170 0.0181263337793805 292 2882180 SGTC_2291 7917025 104.35 µM 2.09349942838508 0.0203952928274946 no 171 0.0181522975202243 249 2964612 SGTC_60 0986-0278 202 µM 2.09053393643445 0.020540272378677 no 172 0.0182849315953069 132 3110598 SGTC_275 trichlorophene 5.69 µM 2.08759355429043 0.0206848854593106 no 173 0.0184172569694865 429 62616 SGTC_2661 dactinomycin 12.96 µM 2.08127235969264 0.0209986940561903 no 174 0.0187044918119088 190 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2363 9053361 176 µM 2.07870476034715 0.0211273053742983 no 175 0.0188222475908951 223 6469797 YMR079W SEC14 SGTC_2520 obtusaquinone 4.71 µM 2.07715222498566 0.0212053948615276 no 176 0.0188937558518147 176 5967872 SGTC_780 0109-0199 192 µM 2.06299198844572 0.021928960657 no 177 0.0195566946805061 235 610414 SGTC_845 0330-0138 4.51 µM 2.05943018855782 0.0221142097820956 no 178 0.0197265231442603 189 9039800 SGTC_497 capsazepine 133 µM 2.05688176526362 0.022247562324604 no 179 0.0198488002051385 179 2733484 A calcium channel blocker. SGTC_1130 3454-2858 15.9 µM 2.05443292782604 0.0223763423887311 no 180 0.0199669044169005 272 715628 YIL048W NEO1 SGTC_227 fluconazole 33.516 µM 2.05375036918816 0.022412348801665 no 181 0.0199999293795268 280 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2011 4012611 177 µM 2.05281252289202 0.0224619018682426 no 182 0.0200453817651644 219 2049887 SGTC_2626 ethyl orsellinate 100 µM 2.05263336484794 0.0224713785607248 no 183 0.020054074556265 198 75653 A natural product. SGTC_251 melphalan 456.522 µM 2.04164892764646 0.0230588830022371 no 184 0.020593184119651 242 460612 A DNA alkylator. SGTC_2857 9024691 58.44 µM 2.03700344761054 0.0233112111985058 no 185 0.0208248482590982 211 16478292 SGTC_1991 st073000 8.92 µM 2.03683897763642 0.0233201871292323 no 186 0.0208330904441299 291 4301969 YIL048W NEO1 SGTC_1658 st012944 20 µM 2.03680654545107 0.0233219574554792 no 187 0.0208347160641449 236 24207260 SGTC_726 3448-4391 34.2 µM 2.02905085059377 0.0237485655976429 no 188 0.0212265556144731 227 1356692 SGTC_1817 st052116 64.4 µM 2.02790196501739 0.023812315499311 no 189 0.0212851272800504 194 4361398 SGTC_2056 5235370 200 µM 2.01614532490819 0.024472981005343 no 190 0.0218923908530939 235 5511916 SGTC_2640 pentamidine 10.38 µM 2.01571581050837 0.0244974060543016 no 191 0.0219148506909765 247 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2300 7976697 71.57 µM 2.01556458206776 0.0245060107793105 no 192 0.0219227632426225 202 2236109 SGTC_2303 7774051 200 µM 2.00879910827142 0.0248935618906134 no 193 0.0222792214372987 217 2953184 SGTC_814 3342-0569 96 µM 1.99830703553698 0.0255047443875895 no 194 0.0228416916118934 248 4346283 SGTC_1581 himbacine 57.9 µM 1.9881135023038 0.0261105218244513 no 195 0.0233995691938918 264 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3147 9097027 49.47 µM 1.98444430261216 0.0263314983573723 no 196 0.0236031656807502 232 25236841 SGTC_1286 0929-0070 131 µM 1.98433770732974 0.0263379413237732 no 197 0.0236091026388252 241 1420408 SGTC_592 k241-0073 46.5 µM 1.97602629587572 0.0268443826569207 no 198 0.0240758995196755 223 4230158 SGTC_808 0711-0032 135 µM 1.97450851440239 0.0269377384348825 no 199 0.0241619751278681 197 4252555 SGTC_1925 st057770 10.1 µM 1.97057195987378 0.0271811319089652 no 200 0.024386428272256 215 5989122 SGTC_1880 MG-132 525 µM 1.95483557491754 0.0281724979323808 no 201 0.0253012403634572 199 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1039 k821-0043 94 µM 1.95304591142579 0.0282871264947598 no 202 0.0254070776113208 233 15992768 SGTC_635 k038-0028 24.7 µM 1.93245072813769 0.029634413576415 no 203 0.0266519489801481 269 4035102 SGTC_2106 5357045 167.29 µM 1.92889799705489 0.0298721264165614 no 204 0.0268717632715363 244 668842 SGTC_287 k060-0039 29.6 µM 1.92572404799085 0.030085830642043 no 205 0.0270694197507643 225 5861974 SGTC_487 nimodipine 119 µM 1.92568970790741 0.0300881496971678 no 206 0.0270715648831358 142 4497 L-type voltage-gated calcium channels inhibitor SGTC_526 4469-0568 170 µM 1.92196950029765 0.0303402619726244 no 207 0.0273047978020897 264 2901964 SGTC_1645 Cervolide 78 µM 1.92050658080683 0.0304398799516583 no 208 0.0273969713575095 181 23173 A fragrance. SGTC_1650 st011916 45.8 µM 1.91767982351107 0.0306331366200649 no 209 0.0275758108122588 189 242528 SGTC_2792 7535235 81.82 µM 1.91624326100215 0.0307317387000221 no 210 0.0276670696018173 241 1281891 SGTC_3045 9092950 49.47 µM 1.91224777475488 0.031007361550164 no 211 0.0279222104790653 249 44120432 SGTC_384 k007-0144 5.16 µM 1.90934210243029 0.0312090872727652 no 212 0.0281089871874001 308 6824886 SGTC_3254 9136651 49.47 µM 1.8966898966636 0.0321001579834677 no 213 0.0289344389703828 258 16454030 SGTC_1155 4088-0394 48.2 µM 1.89599371725467 0.0321497921014693 no 214 0.0289804376546588 257 2326248 SGTC_2697 mebhydrolin 72.4 µM 1.89478135204182 0.0322363789165556 no 215 0.0290606873627324 316 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1621 st003705 32.4 µM 1.8812869879424 0.0332131998871727 no 216 0.029966445048574 278 24207032 SGTC_1412 3909-8563 178 µM 1.88037064800479 0.0332804059165127 no 217 0.0300287904827852 279 23767530 SGTC_1497 4476-2978 41.3 µM 1.87562059143318 0.033630581023289 no 218 0.0303536984210402 298 1528379 SGTC_2247 cerulenin 830 nM 1.87123951287872 0.033956237792125 no 219 0.0306559451333802 255 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1942 st076330 65.2 µM 1.87014187567834 0.0340382330110777 no 220 0.0307320593379672 266 24208414 SGTC_3308 9128332 17.569 µM 1.86433076299086 0.0344750492071096 no 221 0.0311376346462311 368 17332805 YDL196W YDL196W SGTC_2320 7373003 200 µM 1.85785451610118 0.0349672785702662 no 222 0.031594838473777 250 5415828 SGTC_862 0452-0056 10.2 µM 1.85579102477761 0.0351253214043933 no 223 0.0317416751826164 239 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_948 3448-0295 75.3 µM 1.85473261660575 0.0352066120337846 no 224 0.0318172093198489 293 678569 SGTC_446 go6976 132 µM 1.85449161015428 0.0352251439977323 no 225 0.0318344296751166 215 3501 A protein kinase C inhibitor. SGTC_1392 3455-1037 33.9 µM 1.85305384620057 0.0353358658358417 no 226 0.031937320594153 253 981132 SGTC_1514 1189-1591 158 µM 1.85177127512095 0.0354348770446017 no 227 0.0320293370550849 320 767698 YMR146C TIF34 SGTC_3055 9094636 49.47 µM 1.8514462242179 0.035460006244238 no 228 0.0320526921647938 232 25236176 SGTC_3338 9144300 39.5675 µM 1.85026809538317 0.035551208109943 no 229 0.032137459326152 272 4901274 SGTC_2060 5238662 140 µM 1.85025315143424 0.0355523661918934 no 230 0.0321385357407949 258 790130 SGTC_410 α-linolenic acid 100 µM 1.84337053898182 0.0360890310059339 no 231 0.0326374642437993 282 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1426 4048-4480 71.7 µM 1.83669359652368 0.0366159807887484 no 232 0.0331275705598618 253 14224343 SGTC_1672 st016598 6.51 µM 1.82371423904719 0.0376583309787667 no 233 0.0340976425226138 326 4665860 YNL267W PIK1 SGTC_2564 betulinic acid 100 µM 1.82258817822156 0.0377498936565219 no 234 0.0341828937276394 322 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_387 norethindrone acetate 66.7 µM 1.80740913657443 0.0390019632067504 no 235 0.0353492552174116 262 541197 SGTC_2675 theaflavin digallate 100 µM 1.80315166314886 0.0393591572103765 no 236 0.0356821996751875 286 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_860 0443-0016 25.1 µM 1.7980401941122 0.03979151111705 no 237 0.0360853192312636 278 5337942 SGTC_3036 9090181 49.47 µM 1.79353094506585 0.0401761243693071 no 238 0.0364440335692488 217 25236586 SGTC_1568 digitonin 820 nM 1.78854217678791 0.0406051509357768 no 239 0.036844288669786 314 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.7842513168617 0.0409771263601331 no 240 0.0371914185206996 268 689007 SGTC_2036 5160441 105 µM 1.78334873884647 0.0410557217821849 no 241 0.037264776068548 370 134534 YIL048W NEO1 SGTC_970 1315-0089 19.5 µM 1.78161823955197 0.0412067534865923 no 242 0.0374057539909233 262 6811083 YLR033W RSC58 SGTC_3189 9110682 49.47 µM 1.77622907722618 0.0416799877543286 no 243 0.037847583744147 287 17122418 SGTC_1230 0170-0365 3.77 µM 1.7756419640016 0.0417318083190927 no 244 0.0378959743499115 440 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_399 oxolinic acid 75 µM 1.77510034478428 0.0417796596927687 no 245 0.0379406600404705 249 4628 A DNA gyrase inhibitor. SGTC_1992 st073643 23.3 µM 1.77009655417407 0.0422238429095456 no 246 0.0383555287452779 251 3161292 SGTC_2086 5274770 176.623 µM 1.76908210377577 0.0423143592288412 no 247 0.0384400869936635 300 689278 SGTC_2283 7944793 200 µM 1.76812466270011 0.0423999327147472 no 248 0.0385200326224832 319 2970533 SGTC_351 caspofungin 25 nM 1.76462468202115 0.0427139433300318 no 249 0.0388134322319041 446 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2390 9097792 176.6 µM 1.76437967656115 0.042735994904606 no 250 0.0388340387615306 264 4497149 SGTC_1446 4239-0190 62 µM 1.76304175629188 0.0428565760330734 no 251 0.0389467236727979 350 1340085 SGTC_1739 st037196 92.5 µM 1.76084978868103 0.0430547229810752 no 252 0.03913191515105 302 612214 SGTC_1207 2099-0101 141 µM 1.75896021939639 0.043226127478847 no 253 0.0392921327937111 324 5837381 SGTC_812 4251-0442 148 µM 1.75832739882499 0.0432836542244765 no 254 0.0393459091772179 254 5723007 SGTC_821 1114-0266 29.2 µM 1.74917938884761 0.0441221834364358 no 255 0.0401300078471881 289 3123235 SGTC_3259 9138485 49.47 µM 1.74242086246785 0.0447500601715226 no 256 0.040717413991565 347 17646153 SGTC_897 1000-0139 31.4 µM 1.74091182055809 0.0448912303246048 no 257 0.0408495181999687 288 6151020 SGTC_838 0109-0203 71.4 µM 1.73258167625973 0.0456769755005151 no 258 0.0415850242164686 297 759422 SGTC_2735 sertaconazole 140 nM 1.73248521139146 0.0456861389405314 no 259 0.0415936039622455 224 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3088 9117578 49.47 µM 1.72039398337681 0.0468464661967775 no 260 0.042680424963271 286 678341 SGTC_2966 9084041 48.03 µM 1.72024723935159 0.0468606922374603 no 261 0.0426937547310013 312 17741380 SGTC_1380 2291-0730 164 µM 1.7193979984838 0.0469430896180945 no 262 0.0427709632236262 309 2999191 SGTC_485 niflumic acid 177 µM 1.71823393120202 0.0470562216920322 no 263 0.0428769774022189 282 4488 A COX2 inhibitor. SGTC_570 0987-0065 62.6 µM 1.716646327036 0.0472108682626152 no 264 0.0430219062211548 222 3104428 SGTC_824 1304-0008 100 µM 1.7130679264403 0.0475609298679363 no 265 0.0433500219041563 363 768245 SGTC_1129 3453-1384 223 µM 1.70489640521313 0.0483681157204178 no 266 0.0441068734730056 372 1084452 SGTC_3187 9109394 49.47 µM 1.70489558788222 0.0483681970012818 no 267 0.0441069497041674 348 17098090 SGTC_1123 mangostin 811.285 nM 1.70485199408533 0.0483725324189684 no 268 0.0441110157826313 364 5281650 An antioxidant. SGTC_1435 4092-0789 56.7 µM 1.70327244494012 0.0485298288751544 no 269 0.0442585473803845 301 2248285 SGTC_1417 3966-0327 90.4 µM 1.69747939347397 0.0491102225413286 no 270 0.0448030318574293 345 651118 SGTC_493 zm226600 134 µM 1.69381803688247 0.0494798965794469 no 271 0.0451499327901564 340 5240098 A potassium channel opener. YCR052W RSC6 SGTC_713 1488-1073 324 µM 1.69266051008128 0.0495972289076355 no 272 0.0452600530337626 284 3312542 SGTC_2219 9098279 200 µM 1.68885181197838 0.049984864246755 no 273 0.0456239159149503 293 902349 SGTC_2171 5739187 198.077 µM 1.68401698710513 0.0504804107257156 no 274 0.0460891929290662 272 2262761 SGTC_360 0957-0399 1.01 µM 1.67219138849845 0.0517089791135283 no 275 0.0472432940274073 364 6752301 YPR165W RHO1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.66682652885828 0.0522741192142233 no 276 0.0477744517577964 309 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1898 st060199 18.6 µM 1.66585816948458 0.052376647862096 no 277 0.0478708334622804 307 688866 SGTC_2130 NSC 7 2.4545 µM 1.66085121391807 0.0529093272824929 no 278 0.0483716662233373 370 21448 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.65867774449385 0.0531418915481271 no 279 0.048590373179005 366 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2435 5706476 10.6 µM 1.65385591072071 0.0536607278901392 no 280 0.0490783963269182 367 5725375 SGTC_2712 st079126 47.7 µM 1.65162371753428 0.0539022699144221 no 281 0.0493056409910234 319 3152970 SGTC_2894 9048625 32.47 µM 1.64473373363785 0.0546532563506608 no 282 0.0500123664929867 329 4092861 SGTC_1876 myriocin 605 nM 1.64354898452753 0.0547832198741795 no 283 0.0501346995709617 328 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1358 1509-0022 2.48 µM 1.64252463803892 0.054895784514114 no 284 0.0502406622211851 351 3258434 SGTC_1218 1348-1416 30.7 µM 1.63313400814234 0.0559362518014258 no 285 0.0512204077314714 347 6787668 SGTC_1810 st050138 53 µM 1.62914302205642 0.0563831307238004 no 286 0.0516413727588378 291 3444541 SGTC_1025 k007-0731 70 µM 1.62822491309358 0.0564863303515472 no 287 0.0517386020359733 345 6256118 SGTC_1842 st055362 61.2 µM 1.62718246146394 0.0566036870592684 no 288 0.0518491757560863 379 676032 SGTC_3274 9138298 49.47 µM 1.62323712221233 0.0570495840846319 no 289 0.0522693625343086 385 17015756 SGTC_1112 tnp00069 1.16933 µM 1.62156935980277 0.057238901941752 no 290 0.052447793833775 406 145826 SGTC_1204 4049-0315 18.3 µM 1.62034690945966 0.057377983476423 no 291 0.0525788887395438 371 588402 SGTC_2138 5575593 77.673 µM 1.6116421388697 0.0583760508399235 no 292 0.0535199176868363 289 762213 SGTC_2466 5983409 37.09 µM 1.61119900167921 0.0584272223042233 no 293 0.0535681776723437 362 2879657 SGTC_2889 9059656 51.95 µM 1.60964683591517 0.0586067371619967 no 294 0.0537374886519213 384 3949838 SGTC_2294 7971431 200 µM 1.59640141122797 0.0601562939131021 no 295 0.0551996006389725 305 5741572 SGTC_400 oxethazaine 37.5 µM 1.59114201555194 0.0607804053373783 no 296 0.055788809376107 360 4621 A local anesthetic. SGTC_1785 bathophenanthroline 24 µM 1.58797725752771 0.0611583876894198 no 297 0.0561457409390183 418 72812 An iron chelator. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.58661272438598 0.0613219261823907 no 298 0.0563001918810986 325 364106 SGTC_1747 st037496 66.6 µM 1.58485350817538 0.0615332711476606 no 299 0.0564998108827545 413 723305 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.58340590656367 0.0617076063001589 no 300 0.0566644887982254 401 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1026 k007-1105 30.6 µM 1.57352560878582 0.0629078110210188 no 301 0.0577985816823504 478 7066794 SGTC_2654 protoveratrine a 100 µM 1.56032134996213 0.0645400915120318 no 302 0.0593419802688167 365 5702278 A heart drug and vasodilator. SGTC_781 4335-2806 94.4 µM 1.55782447201332 0.0648524164373221 no 303 0.059637431586444 436 845254 SGTC_3224 9130643 49.47 µM 1.55763827905645 0.0648757535367392 no 304 0.0596595095831458 390 17644395 SGTC_724 3910-0327 137 µM 1.55451915012347 0.0652676698675876 no 305 0.0600303161760171 408 2885483 SGTC_1526 st051518 75 µM 1.5506888429519 0.0657514551256568 no 306 0.0604881347708336 356 673993 SGTC_297 0986-0032 24 µM 1.54363418541643 0.0666497595175852 no 307 0.0613384892547107 338 2847425 SGTC_2585 alliin 100 µM 1.54327818917172 0.0666953407895986 no 308 0.0613816466226725 434 87310 A garlic compound which reacts with lipids. SGTC_807 1315-0151 48 µM 1.54029570687313 0.0670781619373743 no 309 0.0617441448918188 451 4011080 SGTC_122 0236-0016 402.397 µM 1.53812691941648 0.0673576055346089 no 310 0.0620087925941891 474 6808838 SGTC_1989 st071868 50.2 µM 1.53454753372008 0.0678207686755217 no 311 0.0624475043600305 434 16414057 SGTC_386 1509-0011 3.07 µM 1.53431813879631 0.0678505354428967 no 312 0.0624757027386756 510 3107280 SGTC_2755 lomerizine 42.69 µM 1.53339028979775 0.0679710380303468 no 313 0.0625898599040353 428 3949 A calcium channel blocker. SGTC_1101 ebselen 5.29 µM 1.53218690711994 0.0681275710805118 no 314 0.0627381592550166 411 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2499 avocadenofuran 51.48 µM 1.52842048517963 0.0686192966968237 no 315 0.0632040859435569 441 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1892 st058411 7.36 µM 1.52768971059194 0.0687150193459268 no 316 0.0632947980073602 470 3934738 SGTC_1889 st059080 5.18 µM 1.52532339263709 0.0690256850660141 no 317 0.0635892279448639 435 176925 Isolated from Daphnopsis sellowiana. SGTC_2936 9038235 15.59 µM 1.52497892683551 0.0690709989099396 no 318 0.0636321769403051 395 4749415 SGTC_2743 auranofin 4.32 µM 1.51813083499783 0.0699766185146118 no 319 0.0644907096128765 375 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_88 0180-0332 8.668 µM 1.51540618839819 0.0703394671302424 no 320 0.0648347855981956 416 3101745 SGTC_3206 9114350 49.47 µM 1.50702904236018 0.0714641391609401 no 321 0.0659016065663163 386 17087243 SGTC_194 1486-1323 56.904 µM 1.5064393754775 0.0715438216949577 no 322 0.0659772095136898 411 5178754 SGTC_367 0335-0881 7.1 µM 1.49576783629195 0.072997690653657 no 323 0.0673570828428251 467 23828853 SGTC_2786 7743617 45.45 µM 1.49024664581155 0.0737587090432177 no 324 0.068079697787085 363 583674 SGTC_2933 9026794 32.47 µM 1.48989385310101 0.0738075419086273 no 325 0.0681260740364543 452 17586027 SGTC_512 prima-1 270 µM 1.48557415061458 0.0744074717747304 no 326 0.0686958982921867 443 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1723 st034307 2.5525 µM 1.47837290882073 0.0754158630377338 no 327 0.0696539962658244 418 867466 SGTC_1638 st008370 60.6 µM 1.47705094943659 0.0756021035228507 no 328 0.0698309902204153 462 24207134 SGTC_1347 1493-0251 600 nM 1.47694105659781 0.0756176012243657 no 329 0.0698457190765058 464 3986378 SGTC_3127 9126946 49.47 µM 1.47331397052961 0.0761304725534333 no 330 0.0703331976753414 382 27243249 SGTC_2395 5646831 180.19 µM 1.47302374636061 0.0761716244941903 no 331 0.0703723164236751 432 6808628 SGTC_2991 9074669 71.4286 µM 1.46899179975612 0.0767450817306016 no 332 0.0709175067125806 517 17333109 SGTC_1838 st055369 84.5 µM 1.46795692431624 0.0768927984861344 no 333 0.0710579620272216 385 676036 SGTC_980 1473-0395 201 µM 1.4644661610078 0.0773926597787881 no 334 0.0715333111887748 384 768876 SGTC_3019 9081971 49.47 µM 1.46352830544242 0.0775273761053811 no 335 0.0716614371067986 449 16451803 SGTC_149 3970-0822 46.1 µM 1.46223431178039 0.077713541390229 no 336 0.0718385060669137 597 3114250 YBL034C STU1 SGTC_3317 9138495 8.753 µM 1.46105928599722 0.0778828847173854 no 337 0.0719995860803322 451 17020139 SGTC_244 nsc-207895 1.295 µM 1.46068788031955 0.0779364694694953 no 338 0.0720505582910506 340 42640 SGTC_3279 9140807 49.47 µM 1.45421852004684 0.0788743331641079 no 339 0.0729428659823407 423 45595718 SGTC_1348 1493-0373 93.8 µM 1.45199954011192 0.079197980465063 no 340 0.0732508665569794 431 3010129 SGTC_382 3229-0966 23.2 µM 1.4513718434326 0.0792897147937389 no 341 0.0733381728780218 465 5722370 SGTC_624 k048-0052 28 µM 1.45039097319551 0.079433224471686 no 342 0.0734747614461899 420 6835531 SGTC_1694 st024011 44.9 µM 1.4486921054114 0.0796822482865655 no 343 0.0737117930687943 478 2787533 SGTC_896 0964-0007 44.5 µM 1.44609528237316 0.0800640371006959 no 344 0.0740752393814192 440 6756758 SGTC_2924 9010168 62.78 µM 1.44360955028592 0.0804307871025947 no 345 0.0744244184887105 475 2993929 SGTC_616 4092-0450 108 µM 1.4435020302164 0.080446679424754 no 346 0.0744395504981541 479 787165 SGTC_52 0329-0193 875 nM 1.44256312553289 0.080585557836939 no 347 0.0745717885817696 468 3739292 SGTC_57 miconazole 162.5 nM 1.43302119832543 0.0820072429278504 no 348 0.0759258896874174 435 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2757 clomiphene 4.22 µM 1.4318345554944 0.0821853580446007 no 349 0.0760955876499706 526 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2100 5377183 190 µM 1.42689535735107 0.0829298633261173 no 350 0.076805029628718 483 2844202 SGTC_1208 2323-2347 50.3 µM 1.4221943666102 0.0836431642131153 no 351 0.0774849168573167 450 5412760 SGTC_1757 st041620 31.8375 µM 1.41784043146485 0.0843079075162615 no 352 0.0781186784894141 458 5289815 SGTC_661 1304-0007 33.6 µM 1.41782963310583 0.0843095610855166 no 353 0.0781202551791691 446 3117130 SGTC_456 gingerol 170 µM 1.41460786821948 0.0848040025356558 no 354 0.0785917502824503 463 442793 A herb. SGTC_3299 9121982 43.1275 µM 1.41118839123659 0.0853311617641132 no 355 0.0790945361048736 480 17594604 YPL160W CDC60 SGTC_1784 st039334 36.3 µM 1.40610931436766 0.086118696661912 no 356 0.0798458334719515 477 3496984 SGTC_3307 9126885 69.2785 µM 1.40448017270429 0.0863724510379424 no 357 0.0800879558964775 522 24824909 SGTC_3050 9093513 49.47 µM 1.40403141748801 0.0864424470688038 no 358 0.0801547471321668 463 25236664 SGTC_943 3253-1379 105 µM 1.40192312978749 0.0867718617516663 no 359 0.0804691013434816 469 668464 SGTC_288 1315-0019 35.1 µM 1.40142400821555 0.0868499853974727 no 360 0.080543658555483 496 6811474 SGTC_1662 st014054 52 µM 1.39793557198546 0.0873974711544697 no 361 0.0810662077015509 423 2838777 SGTC_2337 9009472 200 µM 1.39457740303134 0.0879269420684656 no 362 0.0815716566159465 534 5742383 SGTC_2031 5180455 200 µM 1.39421473894958 0.0879842648730447 no 363 0.0816263842230181 435 29949 SGTC_3077 9117319 49.47 µM 1.39377444124529 0.0880538959210925 no 364 0.0816928642871076 412 17154678 SGTC_571 k831-0106 44.2 µM 1.38936458405347 0.0887535623380681 no 365 0.0823609570005209 458 4783639 SGTC_894 0960-0238 55.9 µM 1.38586216466813 0.0893121983065157 no 366 0.0828944979174614 483 6741907 YDL195W SEC31 SGTC_2198 6589944 200 µM 1.3840289161154 0.0896056424249312 no 367 0.0831748004120797 375 5290268 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.3836558194003 0.0896654509067276 no 368 0.083231933835745 434 15053 SGTC_686 1319-0111 510 µM 1.37313347905797 0.0913644571781712 no 369 0.0848554274231088 536 4562600 SGTC_1859 st055998 20 µM 1.37147288588394 0.0916347535172075 no 370 0.08511379510842 509 676301 SGTC_1884 5633444 25 µM 1.37142788563626 0.0916420864875153 no 371 0.0851208047837193 535 5724239 SGTC_1866 st057638 64 µM 1.36849573278672 0.0921208301871676 no 372 0.0855784783967115 481 688802 SGTC_2719 novobiocin 32.65 µM 1.3639548362495 0.0928658897940464 no 373 0.0862908902529756 396 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1818 st052136 56.3 µM 1.36339407248434 0.092958206790712 no 374 0.0863791741028441 507 674169 SGTC_256 clotrimazole 625 nM 1.36324723369677 0.0929823916611711 no 375 0.0864023028235946 495 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1954 st077032 68.9 µM 1.35931228689958 0.0936322249276894 no 376 0.087023826101487 458 698907 SGTC_2992 9074591 71.4286 µM 1.35801337703043 0.093847466713806 no 377 0.0872297197590859 486 17741321 SGTC_2490 carminic acid 95.39 µM 1.35031884772977 0.0951300179090477 no 378 0.0884568645828767 433 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_727 3032-0951 202 µM 1.34660573219174 0.0957535308722447 no 379 0.0890536235155902 471 3652836 SGTC_3110 9122132 49.47 µM 1.34234458820942 0.0964727685097069 no 380 0.0897421462193184 520 918317 SGTC_3054 9094397 49.47 µM 1.34036558728847 0.0968081503067857 no 381 0.0900632589580492 551 2598354 SGTC_1444 4112-3581 28 µM 1.3362974196853 0.097500271197557 no 382 0.0907260397880855 511 2877249 SGTC_1144 3486-0183 12.5 µM 1.33487099229833 0.0977438078517814 no 383 0.0909592866099111 571 6744069 SGTC_470 aa-861 153 µM 1.33259759741615 0.0981328701670379 no 384 0.0913319470236225 567 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1285 0929-0069 65.5 µM 1.33033276039446 0.0985215948794852 no 385 0.0917043289274577 521 1206237 SGTC_1688 st021091 57.6 µM 1.32978766018082 0.0986153211006933 no 386 0.0917941213913554 496 3656366 SGTC_1708 st033234 31.827 µM 1.32971440363013 0.0986279220327045 no 387 0.0918061936510896 563 674664 SGTC_362 0310-0100 9.03 µM 1.327086437001 0.0990807410039521 no 388 0.0922400456804565 528 790235 SGTC_145 3737-0113 38.366 µM 1.3262868853725 0.0992188111622539 no 389 0.09237234459211 624 6849351 SGTC_617 3770-0098 35 µM 1.32445404008862 0.0995358459024453 no 390 0.0926761486597511 502 5962639 SGTC_753 1322-0200 289 µM 1.32225395906307 0.0999173798453192 no 391 0.0930417992414864 523 5403907 SGTC_1250 0485-0349 40.2 µM 1.31773590132537 0.100704239735214 no 392 0.0937960359583104 526 6842794 YDL195W SEC31 SGTC_2101 5377231 179.231 µM 1.31540653880845 0.10111168021016 no 393 0.0941866545656233 516 2844213 SGTC_1710 st031758 61.5 µM 1.31385861449597 0.101383099065159 no 394 0.0944468940479404 497 5394341 SGTC_1321 1326-2144 215 µM 1.31265588334156 0.101594356578896 no 395 0.0946494648410914 506 3513030 SGTC_3134 9127454 49.47 µM 1.30815045586888 0.102388576058663 no 396 0.0954111413175363 522 24262820 SGTC_1133 3473-0247 50 µM 1.30810237692309 0.102397075723077 no 397 0.0954192936858057 579 711311 SGTC_162 k030-0015 37.8 µM 1.30754593350195 0.102495484231725 no 398 0.0955136827255414 529 1809920 YMR134W ERG29 SGTC_3109 9122853 49.47 µM 1.30554545893444 0.102849841459532 no 399 0.0958535891887971 553 1234709 SGTC_1254 0550-0035 264 µM 1.30274933970195 0.103346626890159 no 400 0.0963301756808326 582 15121435 SGTC_131 0141-0277 33.849 µM 1.30123369016431 0.103616638711139 no 401 0.0965892383360901 549 1547771 SGTC_1062 mesoridazine 14.2 µM 1.2987052487421 0.10406821727606 no 402 0.097022551059833 556 4078 A neuroleptic. SGTC_415 dibenzyl ketone 100 µM 1.29595277162321 0.104561428828661 no 403 0.0974958782852546 563 7593 SGTC_2817 7995342 71.43 µM 1.29544622844639 0.104652379596949 no 404 0.0975831697284853 470 18879975 SGTC_334 1502-1024 68.5 µM 1.29089565467451 0.105472014147907 no 405 0.0983699311966882 565 3296216 SGTC_771 0250-0039 27.3 µM 1.28858429739195 0.105890101903637 no 406 0.0987713226768211 548 3005115 SGTC_751 0833-0568 350 µM 1.28783911132687 0.106025149199335 no 407 0.0989009872258478 558 6954252 SGTC_306 1672-3436 11.6 µM 1.28641960677931 0.106282744956376 no 408 0.099148329649716 578 6797378 SGTC_2142 5622915 118.518 µM 1.28279007011865 0.106943447249828 no 409 0.099782816971566 517 5322196 SGTC_1681 tripelennamine 100 µM 1.28243352738122 0.107008509940438 no 410 0.0998453046298842 485 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2187 6125751 200 µM 1.28146204476592 0.107185933063638 no 411 0.100015711648557 570 874498 SGTC_788 1182-0090 188 µM 1.28142743383886 0.107192258012834 no 412 0.100021786640118 686 5715185 SGTC_2196 6573537 42.6665 µM 1.27940592228161 0.107562144730583 no 413 0.100377074717926 528 2903087 SGTC_27 0485-0001 32.618 µM 1.27281949970074 0.108773675751349 no 414 0.101541050010289 447 2054479 SGTC_1845 st056753 3.01 µM 1.26823064877144 0.109623545957715 no 415 0.10235779748051 576 5375839 SGTC_3335 9143315 29.6265 µM 1.26528447367837 0.11017169421969 no 416 0.102884685139728 544 4899691 SGTC_1758 st042942 75.2445 µM 1.26269456932625 0.110655178232344 no 417 0.103349483232839 555 669317 SGTC_397 arbidol 50 µM 1.26231383064203 0.110726382635058 no 418 0.103417940951886 598 131410 A RNA synthesis inhibitor. SGTC_1475 4092-1048 11.7 µM 1.26042954049189 0.111079259265101 no 419 0.103757225367739 625 2881759 SGTC_2351 9026858 72.31 µM 1.25997028129943 0.111165388037028 no 420 0.103840041618254 528 1409300 SGTC_949 1165-0505 146 µM 1.25730020056166 0.111667078167832 no 421 0.104322475700949 615 6244267 SGTC_1113 artemisinin 1.17947 µM 1.25441259801967 0.112211459957774 no 422 0.104846037925641 595 2240 An anti-malaria and mitochondrial poison. SGTC_2502 avocadyne acetate 18.59 µM 1.25364780648335 0.112355958540246 no 423 0.104985023327056 642 3952079 SGTC_1797 st048695 56.8 µM 1.25235776106586 0.112599999007341 no 424 0.105219765135422 576 592262 YIL048W NEO1 SGTC_1907 st060210 83.7 µM 1.2515872498976 0.112745938604231 no 425 0.105360151455719 639 688793 SGTC_1438 4092-1045 4 µM 1.25099416754218 0.11285836403616 no 426 0.10546830268566 579 1351342 SGTC_2960 9079389 5.97 µM 1.24710068467369 0.113598405023079 no 427 0.106180290971802 593 16457355 SGTC_2073 5212005 126 µM 1.24612406898708 0.113784573571879 no 428 0.106359424857985 491 691789 SGTC_273 hydroxyurea 18.1 mM 1.24454549246839 0.114085951252091 no 429 0.106649433565469 653 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1570 verbenone 133 µM 1.24415189400379 0.114161184520813 no 430 0.106721832450519 613 29025 A natural terpanoid with antifungal properties. SGTC_962 1254-0300 21.5 µM 1.2422660629956 0.114522136605718 no 431 0.107069206142082 578 7340576 SGTC_1369 1866-0067 208 µM 1.24051423626085 0.114858167100878 no 432 0.107392625937341 654 3531355 SGTC_2572 astragaloside iv 100 µM 1.2339134241697 0.116130615080832 no 433 0.10861758335829 574 45006101 An anti-inflammatory agent. SGTC_989 1501-0895 10.3 µM 1.2333764355984 0.116234569486701 no 434 0.108717676220616 587 2830112 SGTC_65 0798-0905 34.986 µM 1.2331164006346 0.116284932792025 no 435 0.108766169693176 703 3602145 SGTC_1554 st069299 38.7 µM 1.23144413052059 0.116609186337673 no 436 0.109078400141873 599 24207999 SGTC_3330 9141424 71.43 µM 1.22930487921136 0.117024921683906 no 437 0.109478759302162 638 27261020 SGTC_3341 9147222 25.867 µM 1.22845644150229 0.117190094924088 no 438 0.109637835658006 566 1939759 SGTC_2424 5537928 59.2 µM 1.22681530704109 0.117510058330588 no 439 0.1099460081392 649 5382802 SGTC_2854 9024559 71.43 µM 1.22569883248 0.11772808475014 no 440 0.110156014869425 580 3163529 SGTC_2483 5729050 27.16 µM 1.22544795098305 0.117777116542391 no 441 0.110203244766413 696 2865180 SGTC_813 k007-0158 173 µM 1.22398652736551 0.118063021609419 no 442 0.110478654980403 674 6523916 SGTC_869 0564-0080 44.1 µM 1.22345070891864 0.118167969137486 no 443 0.110579755294186 611 6843321 SGTC_32 0928-0142 34.1 µM 1.22245282503135 0.118363594436645 no 444 0.110768216635376 558 2244242 SGTC_3121 9125696 49.47 µM 1.22077433297788 0.118693162458823 no 445 0.111085737248195 564 1235365 SGTC_1603 st002045 67.8 µM 1.21871577640315 0.119098239716635 no 446 0.111476043962905 612 5887985 SGTC_2117 5521686 200 µM 1.21458332774565 0.119914355822234 no 447 0.112262525421596 601 803312 SGTC_2028 5153890 36.43 µM 1.214150588562 0.120000044845161 no 448 0.112345112490316 597 2830968 YPR165W RHO1 SGTC_2727 riluzole 51.77 µM 1.21376596485115 0.120076242483602 no 449 0.112418553287624 564 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1362 1611-0397 101 µM 1.21324871580982 0.12017876822282 no 450 0.112517371893221 609 27816 SGTC_1716 st033144 30.6155 µM 1.21198002341606 0.120430501320673 no 451 0.112760013802343 637 674617 SGTC_3186 9110464 49.47 µM 1.21186181500522 0.120453975053822 no 452 0.112782640591607 613 17018021 SGTC_1283 0922-0125 16.4 µM 1.20900889630395 0.121021482986892 no 453 0.113329713786169 660 3360884 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.20865984386497 0.121091046096416 no 454 0.113396777516608 695 6708739 YPR165W RHO1 SGTC_75 0159-0059 199.013 µM 1.20734630641393 0.121353074737449 no 455 0.113649402195883 597 5377270 SGTC_2587 piperic acid 92.2 µM 1.20715884891177 0.121390501841556 no 456 0.113685487447482 567 5370536 SGTC_911 3456-4043 236 µM 1.20667359725111 0.121487423171025 no 457 0.113778935503456 649 914281 SGTC_688 0527-0193 473 µM 1.20635168357047 0.121551750334006 no 458 0.113840958704788 573 4007154 SGTC_1635 st007035 42.4 µM 1.20142193797006 0.122539839921988 no 459 0.114793785231623 796 3716403 SGTC_332 4112-0506 40.9 µM 1.1969378058282 0.123443495822466 no 460 0.115665398568534 628 2790355 SGTC_1619 st003326 88.7 µM 1.19302380664502 0.124236063671097 no 461 0.116430024790437 585 2849032 SGTC_2044 5102272 200 µM 1.18987789701584 0.124875671808149 no 462 0.117047193505814 573 592666 SGTC_985 1493-0307 8.71 µM 1.18774150422675 0.125311340391849 no 463 0.117467633331115 579 3278274 SGTC_2412 st077135 33.4 µM 1.18685571098357 0.125492288553097 no 464 0.117642269723032 636 13258915 SGTC_2963 9082507 9 µM 1.18325406647972 0.126229903386791 no 465 0.118354235587755 596 16459611 SGTC_1047 2043-3044 82 µM 1.18050089732555 0.126795784945342 no 466 0.1189005268866 649 669592 SGTC_889 0919-1524 82.7 µM 1.17884670097872 0.127136633751063 no 467 0.119229612175545 602 3905452 SGTC_2544 sphondin 68.51 µM 1.17841074795207 0.127226568360962 no 468 0.119316447468101 606 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1950 st077106 7.18 µM 1.17784324732698 0.127343706780348 no 469 0.119429551916235 648 13831864 SGTC_1990 st072050 59.8 µM 1.17570262189762 0.12778623065054 no 470 0.119856865269492 655 17233948 SGTC_208 k072-0098 12.366 µM 1.17448037144445 0.128039380924129 no 471 0.120101334767829 731 5948901 SGTC_1895 st058434 18.3 µM 1.17362461097053 0.128216831684302 no 472 0.120272709464702 672 5393175 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.17232260797013 0.128487142903015 no 473 0.120533779074588 735 688664 SGTC_2389 9091542 195.52 µM 1.16395383846131 0.130234040159128 no 474 0.12222135972918 676 3626624 YOL127W RPL25 SGTC_2656 pseudo-anisatin 100 µM 1.16363092134619 0.130301773588491 no 475 0.122286807392983 624 6708809 A neurotoxin. SGTC_1044 1222-0021 1.78 µM 1.16218603783712 0.130605143369862 no 476 0.122579952406196 645 4306703 SGTC_2118 5526350 200 µM 1.16201284442309 0.130641540054491 no 477 0.122615123793166 659 743594 SGTC_2867 9039098 71.43 µM 1.16109804243131 0.130833902502168 no 478 0.122801015372013 650 6463460 SGTC_1698 5-fluorocytosine 1.055 µM 1.16101586256773 0.130851192671748 no 479 0.122817724332753 647 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1668 st014914 51.6 µM 1.15662867417245 0.131776524939484 no 480 0.123712050958084 635 2839556 SGTC_1257 0669-0121 16 µM 1.15441232440676 0.132245703090604 no 481 0.124165582398345 716 4307855 SGTC_1571 st070080 73.4 µM 1.15409677495855 0.132312595149861 no 482 0.124230247720892 653 4315245 SGTC_1500 4488-1866 171 µM 1.15402353255838 0.132328124846118 no 483 0.124245260601474 702 2900003 SGTC_51 1013-0126 23.419 µM 1.15296643068864 0.132552403667982 no 484 0.124462081682792 628 1627850 SGTC_1602 st001878 87.6 µM 1.15075947694266 0.133021483264322 no 485 0.124915600085987 650 595405 YLR310C CDC25 SGTC_3041 9091929 49.47 µM 1.15074233478535 0.133025131231118 no 486 0.124919127229755 685 25236887 SGTC_3334 9142812 21.919 µM 1.14780505634337 0.133651220957609 no 487 0.125524524749729 659 45283678 SGTC_1093 fluphenazine 7.97 µM 1.14749239221233 0.133717985374129 no 488 0.125589087796877 683 6602611 An atypical antipsychotic. SGTC_1293 1000-1278 195 µM 1.14748493632198 0.133719577739929 no 489 0.125590627671071 687 678847 SGTC_1063 disulfiram 1.84 µM 1.14665035875521 0.133897902139704 no 490 0.125763077279841 655 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1 0258-0098 57.368 µM 1.14377112382 0.134514363176516 no 491 0.12635928411383 580 6790032 YDR047W HEM12 SGTC_2094 5332512 191.667 µM 1.14175492041566 0.134947202239952 no 492 0.126777952587884 693 755774 SGTC_2881 9058953 51.95 µM 1.14150094660556 0.135001793077144 no 493 0.126830759149193 693 17122249 SGTC_375 3970-0961 9.27 µM 1.14109878045293 0.135088268350216 no 494 0.126914409372571 676 2898222 SGTC_2110 5483698 200 µM 1.13885983077674 0.135570390027856 no 495 0.127380811063757 663 2848765 YHR062C RPP1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.13836658384645 0.135676761062959 no 496 0.127483720709075 648 115019 SGTC_3291 9121177 71.43 µM 1.13771056407065 0.135818323395433 no 497 0.127620680379865 570 17015612 SGTC_2144 5628481 200 µM 1.13654274037462 0.136070577990648 no 498 0.127864744304862 623 2818399 SGTC_2953 9074162 66.49 µM 1.1337638927594 0.136672109035923 no 499 0.12844680028414 617 16451992 SGTC_1432 4049-0298 68.4 µM 1.13358697884013 0.136710466670734 no 500 0.128483918756493 660 741646 SGTC_2493 resveratrol 26.09 µM 1.13353400024596 0.136721954669531 no 501 0.128495035692627 616 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1964 st076914 61 µM 1.13332903097484 0.136766406888397 no 502 0.128538052376519 682 24208661 SGTC_1946 st076057 65.1 µM 1.13301351995749 0.136834851891109 no 503 0.128604287871676 546 953009 SGTC_614 0462-0418 107 µM 1.13265425506791 0.13691281709188 no 504 0.128679737490289 612 5188303 SGTC_1893 st059353 36.1 µM 1.13186163715676 0.137084932952876 no 505 0.128846304672428 662 3112488 SGTC_2474 5321570 43.32 µM 1.12916259129907 0.137672135406607 no 506 0.129414625635232 657 2841384 SGTC_3227 9130768 49.47 µM 1.12880826628361 0.137749349377422 no 507 0.129489362392309 697 17720899 SGTC_795 0685-0265 78 µM 1.12802992706852 0.137919067618689 no 508 0.129653640222842 694 302754 SGTC_1735 st034310 56.75 µM 1.12506637173868 0.138566581285352 no 509 0.130280455040455 682 871153 SGTC_2217 6934799 96.0675 µM 1.12442253273557 0.138707528503417 no 510 0.13041690870862 667 675606 SGTC_2221 6807166 181.081 µM 1.12369110375379 0.138867769096368 no 511 0.130572045885452 612 674925 SGTC_3267 9137951 49.47 µM 1.12290490230648 0.139040149693552 no 512 0.13073894263009 635 16643986 SGTC_1487 3970-0795 2.82 µM 1.12003064043061 0.139671592642318 no 513 0.131350352624345 729 3765103 SGTC_3012 9080433 71.4286 µM 1.1178458101825 0.140152877667402 no 514 0.131816426221636 716 17688859 SGTC_2353 9059630 146.67 µM 1.11777575840046 0.140168327632031 no 515 0.131831388701184 664 4779114 SGTC_3008 9078912 71.4286 µM 1.1168560908557 0.140371268186721 no 516 0.132027930726588 670 16648731 SGTC_1734 st037168 69.4 µM 1.11602087153049 0.140555746579679 no 517 0.132206600344082 678 708907 SGTC_371 0195-0006 7.36 µM 1.11243976231954 0.141348586205691 no 518 0.132974558205068 616 3928593 SGTC_3181 9108277 49.47 µM 1.11164031145016 0.14152599370288 no 519 0.133146416458654 663 17097298 SGTC_3031 9088762 49.47 µM 1.11074353010973 0.141725179441642 no 520 0.133339379716507 706 205253 SGTC_2223 6903751 107.57 µM 1.11001226717903 0.141887742064199 no 521 0.133496870196898 647 5598863 SGTC_535 2293-4129 48.2 µM 1.10874932867655 0.142168795478319 no 522 0.133769167646708 773 396118 YIL048W NEO1 SGTC_1779 st039427 55 µM 1.10735566157748 0.142479378141791 no 523 0.134070093852799 787 1124498 SGTC_1677 st019204 53.9 µM 1.10506738621315 0.142990321462628 no 524 0.134565195576858 663 3945625 SGTC_3229 9132204 49.47 µM 1.10387130007914 0.14325788468435 no 525 0.13482448506834 662 17682924 SGTC_1399 3562-5772 25 µM 1.10204884399954 0.143666215948039 no 526 0.135220218725133 607 23847490 SGTC_514 4466-0038 2.65 nM 1.09500765847971 0.145251206394008 no 527 0.136756640650852 770 5722064 SGTC_2872 9044037 25.97 µM 1.09459578247476 0.145344283672212 no 528 0.136846882060596 665 6465195 SGTC_558 k064-0027 21.3 µM 1.09197895840153 0.145936580507805 no 529 0.137421174969837 720 5088526 SGTC_1853 st056710 91.2 µM 1.09126953114782 0.146097432656647 no 530 0.137577150273443 737 269167 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.08901579300926 0.146609224401156 no 531 0.138073460658012 765 4174840 SGTC_508 roscovitine 141 µM 1.08860527740141 0.146702576015903 no 532 0.138163994273814 721 160355 A CDKinase inhibitor. SGTC_714 4296-0578 26.1 µM 1.08847503566775 0.146732201434398 no 533 0.138192725766984 673 1589775 SGTC_1002 4049-0206 172 µM 1.08650746418018 0.147180243184336 no 534 0.138627270199517 761 4662749 SGTC_2124 5246320 200 µM 1.08508875327293 0.147503870681836 no 535 0.13894117402221 699 579342 SGTC_2141 5621638 7.665 µM 1.08441044212862 0.147658771134259 no 536 0.139091427951224 725 2856238 SGTC_3172 9105863 49.47 µM 1.08438347427545 0.147664931816724 no 537 0.139097403934316 647 2348785 SGTC_794 k038-0031 316 µM 1.07953087469435 0.148776288838223 no 538 0.140175568940741 801 6624242 SGTC_2556 citropten 84.59 µM 1.07879434581502 0.148945458271361 no 539 0.140339707992893 763 2775 A potential DNA crosslinker. SGTC_2822 7994718 71.43 µM 1.07851001083793 0.14901080004299 no 540 0.140403108334295 625 1018011 SGTC_2190 6049624 200 µM 1.07814325629304 0.149095110569525 no 541 0.140484915113265 650 2265554 SGTC_1251 0490-5699 265 µM 1.07628870260212 0.149521928231465 no 542 0.140899079806637 784 3883818 SGTC_958 1222-0007 33 µM 1.07454057082227 0.149924999236516 no 543 0.141290235670205 778 7312461 SGTC_932 2857-0803 154 µM 1.07378606116909 0.150099192025308 no 544 0.141459289321528 774 674898 SGTC_33 0986-0033 35.816 µM 1.07174309353465 0.150571526662678 no 545 0.141917719650703 705 2848082 SGTC_2943 9068529 45.32 µM 1.07081636250577 0.150786113153792 no 546 0.142126004105273 786 3270634 SGTC_561 1550-0330 72.9 µM 1.0655882734878 0.152000500774061 no 547 0.143304901221461 702 6812934 SGTC_2750 bromebric acid 70.15 µM 1.06342335238806 0.152505268366145 no 548 0.143795003634834 790 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3351 9150312 21.596 µM 1.06270901839666 0.152672064474269 no 549 0.143956964906091 729 4904905 SGTC_2643 anethole 100 µM 1.06228346308996 0.152771488613762 no 550 0.144053509716491 784 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3058 9093861 49.47 µM 1.06029082227544 0.153237608222105 no 551 0.144506156624272 718 17217477 SGTC_2710 st078562 53.7235 µM 1.05931320859944 0.153466636365939 no 552 0.1447285807184 732 17250908 SGTC_212 3807-4682 38.772 µM 1.05701533297833 0.154005858092075 no 553 0.145252294864755 890 3125501 YBL034C STU1 SGTC_453 enantio-paf c16 10 µM 1.0546975603414 0.15455101726541 no 554 0.145781833965904 866 13871343 A lipid and platelet activating factor SGTC_22 0964-0034 14.468 µM 1.05465011622749 0.15456218981636 no 555 0.145792687008706 782 138402 SGTC_1513 0337-0559 19 µM 1.05280536478621 0.154997021771211 no 556 0.146215102849728 667 775073 SGTC_3046 9092212 49.47 µM 1.05265347117686 0.155032861036532 no 557 0.146249920421332 745 25236637 SGTC_1451 4152-0210 104 µM 1.05246824518219 0.155076572475782 no 558 0.146292386090246 769 659563 SGTC_1091 telmisartan 47.6 µM 1.05044050015963 0.155555631675867 no 559 0.146757816674263 769 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1450 4112-4260 37.6 µM 1.05043487818105 0.155556961236235 no 560 0.146759108472797 785 1633175 SGTC_71 0417-1750 47.813 µM 1.04872614554825 0.155961412480147 no 561 0.147152088613493 793 6811472 SGTC_2674 ligustilide 100 µM 1.04700001646992 0.156370684543554 no 562 0.147549785297482 711 5319022 A signalling regulator. SGTC_3070 9117005 49.47 µM 1.04625416891952 0.156547746619795 no 563 0.14772184965126 698 8779016 SGTC_935 2996-0153 430 µM 1.04613286732853 0.156576555745675 no 564 0.147749846192075 767 23738523 SGTC_2541 muurolladie-3-one 83.07 µM 1.04448806515527 0.156967540755119 no 565 0.148129819074591 723 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3113 9123498 49.47 µM 1.04346070008193 0.15721208073121 no 566 0.148367486621929 786 8897275 SGTC_1939 st074455 53.6 µM 1.04320156980812 0.157273800107638 no 567 0.14842747329736 775 1644229 SGTC_1547 harmine 94.2 µM 1.04310022532466 0.157297942563108 no 568 0.148450938181463 826 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_972 1319-0219 195 µM 1.04277512031645 0.157375406075307 no 569 0.148526228398371 747 23903702 SGTC_2280 7785178 200 µM 1.04250355546885 0.157440131669284 no 570 0.148589138958223 737 2954328 SGTC_2202 7226349 200 µM 1.04235588216714 0.157475335917234 no 571 0.148623356349117 739 844334 SGTC_1404 3909-7820 48.3 µM 1.04217585259216 0.157518260664151 no 572 0.148665078139379 750 23741373 SGTC_593 1203-0218 61.7 µM 1.04162143375459 0.157650499952324 no 573 0.148793613687118 792 3666956 SGTC_1683 st010134 710 nM 1.0410850915428 0.157778497013202 no 574 0.148918029037887 745 3818134 SGTC_543 3844-1095 191 µM 1.0403947495634 0.157943346268782 no 575 0.149078270012647 811 4230703 SGTC_3092 9117248 49.47 µM 1.03991633491645 0.15805765494992 no 576 0.149189386324836 822 17141857 SGTC_2332 7982454 138.89 µM 1.03879031256069 0.158326912268316 no 577 0.149451133869147 774 2981748 SGTC_2379 9035213 200 µM 1.03788132436542 0.158544491228785 no 578 0.149662654585029 829 646551 SGTC_1669 st015249 58.4 µM 1.03713213597781 0.158723967228782 no 579 0.149837140117851 788 722793 SGTC_2225 6654152 15.4 µM 1.0370166549078 0.158751643783515 no 580 0.149864047654938 689 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2824 7998404 51.95 µM 1.03651774624406 0.158871250151805 no 581 0.149980332343231 723 837851 SGTC_2401 5128683 200 µM 1.03579559184356 0.159044481148262 no 582 0.150148757270352 700 708373 SGTC_1783 st039459 87.517 µM 1.03512210413538 0.159206149423095 no 583 0.150305945452538 810 729761 SGTC_441 propafenone 146 µM 1.03247592368226 0.159842397310697 no 584 0.150924610388426 715 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2467 5474540 200 µM 1.03225165038471 0.159896397958747 no 585 0.150977122264715 765 5413519 SGTC_1378 2093-0007 380 nM 1.03091569737107 0.160218316678248 no 586 0.151290177366006 751 3618014 SGTC_1750 st081859 2.357 µM 1.02892073145622 0.160699822958915 no 587 0.151758462774182 926 5291695 SGTC_96 0929-0093 37.281 µM 1.02742172906136 0.161062244321281 no 588 0.152110962036142 743 6991579 SGTC_876 0720-0963 56.8 µM 1.02116328132208 0.162581138353459 no 589 0.153588542854715 819 765861 SGTC_853 0419-0306 21 µM 1.01872209910115 0.163176119449795 no 590 0.154167459004964 709 762713 SGTC_644 1498-1197 63.3 µM 1.01780841830978 0.163399171229382 no 591 0.154384505298793 815 6741615 SGTC_3156 9099931 49.47 µM 1.01711843693583 0.163567743711581 no 592 0.154548545275278 834 18111053 SGTC_1107 amlodipine 47 µM 1.0151603179666 0.164046755403265 no 593 0.155014706447106 768 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_128 0906-2981 13.371 µM 1.01479216959997 0.164136916512979 no 594 0.155102453572814 718 6740226 SGTC_1390 3413-2614 145 µM 1.01304702134008 0.164564747983827 no 595 0.155518850847188 804 3421432 SGTC_2962 9082311 13.18 µM 1.0113313624849 0.164986053813945 no 596 0.155928930102901 726 16459453 SGTC_2326 6164455 177.58 µM 1.01130805966556 0.164991780974852 no 597 0.155934504878375 723 2888790 SGTC_2911 7942208 15.64 µM 1.0108081615546 0.165114672513127 no 598 0.156054128043977 740 1243384 SGTC_3196 9111891 49.47 µM 1.00973720524599 0.165378148493682 no 599 0.156310606147617 765 18891510 SGTC_1367 1812-0510 76.9 µM 1.00948781415533 0.165439542555525 no 600 0.156370371438145 775 1142582 YDR527W RBA50 SGTC_2356 9061756 188.97 µM 1.00938379363103 0.165465154252642 no 601 0.156395303868362 789 20104043 SGTC_2684 capsaicin 100 µM 1.00898995628415 0.165562147227064 no 602 0.156489725518495 761 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2002 4023503 131 µM 1.00837159097677 0.165714510391944 no 603 0.156638052980484 902 4736863 YCR052W RSC6 SGTC_627 1391-0720 175 µM 1.00304501137897 0.167030714343247 no 604 0.157919572107875 776 997839 SGTC_3258 9138477 49.47 µM 1.00282455657333 0.167085333867937 no 605 0.157972759165399 793 4970355 SGTC_2581 avocatin a 64 µM 1.00230429685023 0.167214278224826 no 606 0.158098323958668 805 6710728 A skin care supplement. SGTC_1067 clotrimazole 1.36 µM 1.00053475265663 0.167653332884525 no 607 0.158525894040716 810 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.999783188496518 0.167840033448217 no 608 0.158707721655225 866 1273210 SGTC_1994 st072947 40.9 µM 0.998936109675525 0.168050621771912 no 609 0.158912821182863 803 5286565 YDL195W SEC31 SGTC_108 0509-0257 621.132 µM 0.997187978046234 0.168485753934069 no 610 0.159336637607528 826 536624 SGTC_3103 9120822 49.47 µM 0.996133317539474 0.168748622374394 no 611 0.159592686763776 833 17141819 SGTC_589 1227-0070 34.1 µM 0.994635712772904 0.169122344861053 no 612 0.159956735805274 805 2841384 SGTC_1323 1348-1351 11.2 µM 0.993106828794474 0.169504420792464 no 613 0.160328948234102 776 6989654 SGTC_1430 4049-0248 69.1 µM 0.992927807025603 0.169549195444043 no 614 0.160372568732307 896 22774488 SGTC_1633 st005664 67.9 µM 0.992922008068369 0.16955064593246 no 615 0.160373981837638 809 2063822 SGTC_2298 7976326 193.81 µM 0.992751379422724 0.169593328699153 no 616 0.160415564721986 736 2235818 SGTC_572 0960-0087 17.7 µM 0.990434314653041 0.170173624872842 no 617 0.16098094001952 882 6796365 SGTC_2066 5222451 176 µM 0.989909817702084 0.170305158653408 no 618 0.16110910017812 859 2281147 SGTC_539 4859-0462 2.54 µM 0.988929330476077 0.170551220677667 no 619 0.161348859486093 829 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2065 5221596 34.26 µM 0.9885188450707 0.170654303220147 no 620 0.161449304874487 774 788581 SGTC_2189 6047310 154.431 µM 0.983666557291442 0.171875848004059 no 621 0.162639744096115 781 711535 SGTC_2951 9072950 58.06 µM 0.980109699176788 0.172774810864272 no 622 0.163515985985097 905 16488155 SGTC_1413 3910-0535 34.4 µM 0.978346674868194 0.173221507748198 no 623 0.163951446232098 874 2876951 SGTC_2203 7227154 166.4 µM 0.977977520198484 0.173315133380834 no 624 0.16404272120561 825 896304 SGTC_2394 5221648 200 µM 0.976961024442561 0.173573105222498 no 625 0.164294224184405 918 788586 SGTC_2178 5812956 200 µM 0.976795094781758 0.173615238944194 no 626 0.164335302486951 820 5403383 SGTC_2139 5578692 56.4705 µM 0.976339107815732 0.173731059035672 no 627 0.164448222987998 785 650991 YMR113W FOL3 SGTC_2797 7859098 81.82 µM 0.974692271346923 0.174149762527771 no 628 0.164856463898035 817 972681 SGTC_43 0570-0105 72.5 µM 0.974122433221633 0.174294791488171 no 629 0.164997876087005 900 1114046 YDL195W SEC31 SGTC_2343 7990716 14.84 µM 0.97124937725866 0.17502717864276 no 630 0.165712055386717 834 6456862 SGTC_2866 9034245 58.44 µM 0.970986308549886 0.175094336430297 no 631 0.165777548289504 819 6462273 SGTC_2778 tioconazole 65.09 nM 0.969143183729448 0.175565318964087 no 632 0.166236877108457 800 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2552 juarezic acid 87.02 µM 0.965229122794283 0.176568157716588 no 633 0.167215031590254 997 1549512 SGTC_725 1497-0963 19 µM 0.957637582549749 0.178523523379776 no 634 0.16912277053245 883 3549977 SGTC_2869 9037858 32.47 µM 0.954965016929463 0.17921513418344 no 635 0.169797694166617 855 27187042 SGTC_3006 9075424 71.4286 µM 0.953475213895315 0.179601398315387 no 636 0.17017467435771 811 7465181 SGTC_2926 9010726 65.15 µM 0.950547239601184 0.180362063117259 no 637 0.170917131272016 831 2994293 SGTC_2477 5967686 25.23 µM 0.949495272867575 0.180635848705481 no 638 0.171184387549659 833 776118 SGTC_1509 1326-1131 80 µM 0.948768032077309 0.180825273172113 no 639 0.171369302067258 834 768313 SGTC_113 0099-0221 2.5 µM 0.944133903117312 0.182035247930879 no 640 0.172550613152908 832 89219 SGTC_1213 1315-0166 115 µM 0.942180001874407 0.182546926721667 no 641 0.173050245349562 748 768401 SGTC_1181 1222-0449 220 µM 0.939497356797916 0.183250907338225 no 642 0.173737724345499 871 658318 SGTC_3166 9102297 49.47 µM 0.934455788034149 0.184578490884058 no 643 0.175034415929441 858 25237072 SGTC_1721 st082152 9.2685 µM 0.932698580169323 0.18504261411198 no 644 0.175487809092549 824 5296051 SGTC_2277 7947813 106.88 µM 0.932337109997965 0.185138177401117 no 645 0.175581167527575 837 1246798 SGTC_2241 6772625 37.8075 µM 0.931808741332408 0.185277919442243 no 646 0.175717688161319 823 2285411 SGTC_19 0279-0214 38.434 µM 0.931666610393321 0.18531552116591 no 647 0.175754423627059 955 3566274 YBR002C RER2 SGTC_2350 9023895 38.85 µM 0.931139484447592 0.185455017351432 no 648 0.175890708200731 858 2997209 SGTC_882 0843-0131 351 µM 0.930966833015691 0.185500721198678 no 649 0.175935360517438 920 5425421 SGTC_2832 7992762 51.95 µM 0.930279245468148 0.185682806970919 no 650 0.176113260412871 748 2985177 SGTC_64 000l-0018 272.079 µM 0.928075909125954 0.186267037409218 no 651 0.176684097560746 925 6811119 SGTC_2842 9000675 19.48 µM 0.925283725475165 0.187009039220988 no 652 0.177409170980412 807 2989072 SGTC_2877 9040724 71.43 µM 0.924508638357796 0.187215336610477 no 653 0.177610778013524 894 6463895 SGTC_127 0180-0333 59.125 µM 0.922307339678575 0.187802001821356 no 654 0.17818414332412 942 771601 SGTC_903 1134-0042 114 µM 0.922072730418334 0.18786459410854 no 655 0.178245319977988 869 701009 SGTC_3343 9148379 18.9835 µM 0.917414381313716 0.189110078594082 no 656 0.179462769773229 917 1955036 SGTC_3336 9143619 71.43 µM 0.916861722029174 0.189258177633464 no 657 0.179607552191459 936 45595730 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.914946615804838 0.189771931011269 no 658 0.180109828100624 833 1241132 A phosphatase inhibitor. SGTC_2373 9071805 200 µM 0.914134530206128 0.189990042757601 no 659 0.180323080190021 919 10149009 SGTC_844 0330-0132 15.3 µM 0.911948556189533 0.19057792171314 no 660 0.180897899522051 961 2828079 SGTC_2930 9013230 14.89 µM 0.911721022452972 0.190639176979783 no 661 0.180957797254266 918 2995857 SGTC_777 1315-0167 517 µM 0.909573693311387 0.19121786307469 no 662 0.181523688671771 845 4221767 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.909150891821187 0.191331931075674 no 663 0.18163524106272 879 5377381 SGTC_237 nikkomycin 200 µM 0.908934473314132 0.191390334956432 no 664 0.18169235774499 924 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.908910880369494 0.191396702537731 no 665 0.181698585020765 868 17037758 SGTC_1028 k015-0029 4.8 µM 0.908117851692414 0.191610811300622 no 666 0.181907979863494 885 4588309 SGTC_3161 9100388 49.47 µM 0.906927707478368 0.191932411933182 no 667 0.182222513941273 952 25236368 SGTC_1371 2421-0008 32.7 µM 0.906222024611981 0.192123257411657 no 668 0.182409173871819 867 2827552 SGTC_2655 perillic acid 100 µM 0.905656331207184 0.192276327829929 no 669 0.182558891465559 871 5702197 An apoptosis inducer. SGTC_1661 st013063 9.66 µM 0.904915840593024 0.192476809141102 no 670 0.182754987198358 967 721395 SGTC_1744 st037937 38.9 µM 0.901305994106254 0.193455972096656 no 671 0.183712823825555 886 1016152 SGTC_1244 0416-0015 52.5 µM 0.901251735980502 0.193470712636983 no 672 0.183727244493263 893 96201 SGTC_1294 1000-1494 117 µM 0.899951366794123 0.193824194528274 no 673 0.184073066208701 879 712797 YDL207W GLE1 SGTC_1443 4112-3303 14 µM 0.897065619207334 0.194610037878884 no 674 0.184841951596778 919 704433 SGTC_2222 6885208 172.143 µM 0.895043960068133 0.195161726849403 no 675 0.185381794485019 905 609514 SGTC_2418 pentamidine 31.67 µM 0.894558531311526 0.195294336501537 no 676 0.185511563928578 874 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2784 7567673 72.73 µM 0.893423715637231 0.195604559494015 no 677 0.185815153564246 945 3471247 SGTC_1335 1486-0900 202 µM 0.89233160995715 0.1959033892636 no 678 0.186107608071731 931 X1335 SGTC_2371 9071574 200 µM 0.892251277834129 0.195925381245684 no 679 0.186129131435561 890 45596039 SGTC_3163 9099914 49.47 µM 0.892224337013181 0.19593275698745 no 680 0.186136350027835 902 16268368 SGTC_411 enrofloxacin 100 µM 0.891659925453144 0.196087317882422 no 681 0.186287619795414 974 71188 A bacterial gyrase inhibitor. SGTC_1465 k213-0056 144 µM 0.890546897412276 0.196392330904352 no 682 0.186586149176218 879 24048857 YMR208W ERG12 SGTC_2634 4'-methoxyflavone 100 µM 0.890336305485032 0.196450073627519 no 683 0.186642666127193 847 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2064 5220758 200 µM 0.89029530164185 0.196461317769607 no 684 0.186653671638224 938 788518 SGTC_908 3448-7491 47.7 µM 0.889923705982223 0.196563235131481 no 685 0.186753426952257 969 1203031 SGTC_1573 oleylamine 1.06 µM 0.887802847663021 0.197145534836293 no 686 0.187323405439414 911 5356789 An amine of the fatty acid oleic acid. SGTC_2193 5925765 200 µM 0.887657790153994 0.197185399710397 no 687 0.187362428750387 918 877370 SGTC_1499 4480-0877 67.3 µM 0.887087379332713 0.197342207971103 no 688 0.187515929162553 874 2861909 SGTC_2098 5376439 882.5 nM 0.885738292135503 0.197713377559066 no 689 0.187879284441461 969 2844116 SGTC_102 gallobenzophenone 83.616 µM 0.885630662782497 0.197743007402734 no 690 0.187908291418188 925 70837 SGTC_3325 9138760 55.175 µM 0.885059690666173 0.197900238152701 no 691 0.188062219239274 893 43844959 SGTC_1114 scopoletin 1.73284 µM 0.8838694504899 0.198228241798363 no 692 0.188383345075726 931 5280460 A coumarin with genotoxic properties. SGTC_1904 st060225 78 µM 0.882865758838344 0.198505091709428 no 693 0.188654402969494 919 66595 SGTC_13 0199-0087 65 µM 0.882277974168661 0.198667329558743 no 694 0.188813252211135 987 4589825 SGTC_2790 5423970 71.43 µM 0.882130883527223 0.198707941403422 no 695 0.188853016456252 962 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2980 9014342 25.29 µM 0.881792511790219 0.198801385114449 no 696 0.188944510909703 847 2996599 SGTC_2695 st077686 51.995 µM 0.881435769630833 0.198899930627665 no 697 0.189041002224027 897 2876092 SGTC_1837 st055472 66.5 µM 0.877921622307951 0.199872242050081 no 698 0.189993127138411 943 676091 SGTC_1656 st012921 11 µM 0.87777439839626 0.19991303897071 no 699 0.190033080289248 870 6732821 SGTC_1655 st012546 55.1 µM 0.877163587544381 0.200082353010733 no 700 0.190198895318631 884 720985 YLR208W SEC13 SGTC_1878 temozolomide 1 mM 0.876782553625928 0.200188017556703 no 701 0.190302378487319 933 5394 DNA alkylating agent. SGTC_527 4476-4215 268 µM 0.876155823548733 0.200361889051446 no 702 0.19047266430279 910 4418754 SGTC_460 trequinsin 123 µM 0.875985833940288 0.20040906429937 no 703 0.190518867487388 988 5537 A vasodilator. SGTC_2472 5377652 49.4 µM 0.875740923327019 0.200477043236202 no 704 0.190585446302623 928 1610903 SGTC_1701 st028638 40.4 µM 0.875704842120822 0.200487059333996 no 705 0.19059525616563 960 3490878 SGTC_3298 9116858 71.43 µM 0.875481356699336 0.200549105303622 no 706 0.190656024936021 957 2506942 SGTC_1326 1431-2094 10.8 µM 0.873681060052069 0.201049339775893 no 707 0.191145984088022 914 616278 SGTC_1168 k815-0004 80.5 µM 0.872986073482959 0.201242650360212 no 708 0.191335334290363 931 642433 SGTC_2082 5219693 150 µM 0.871525192797605 0.201649357620636 no 709 0.191733728201676 963 2834649 SGTC_3129 9127257 49.47 µM 0.865359768515021 0.203371219829137 no 710 0.193420677690672 818 837894 SGTC_1035 k081-0041 55.2 µM 0.863988808510687 0.203755286510972 no 711 0.193797019252796 995 731709 SGTC_952 1185-0122 232 µM 0.863091688466419 0.204006843494627 no 712 0.194043528685576 943 678600 SGTC_2242 6630449 61.2675 µM 0.859986933743062 0.204878859582566 no 713 0.194898122570876 859 691249 YDR170C SEC7 SGTC_3065 9113888 49.47 µM 0.85960739161119 0.204985611400359 no 714 0.195002749555218 903 16648368 SGTC_3010 9080089 71.4286 µM 0.859243166957139 0.205088086036553 no 715 0.195103186128709 968 17027233 SGTC_2592 piperlongumine 83.33 µM 0.857175611580585 0.205670369631174 no 716 0.195673919387366 900 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_772 k072-0172 35.3 µM 0.856886865601393 0.205751766893204 no 717 0.195753706143766 898 5861980 SGTC_1489 4065-0444 182 µM 0.855715786676517 0.206082089048813 no 718 0.196077502967502 948 2877968 SGTC_941 3237-0776 460 µM 0.854515950500457 0.206420848586414 no 719 0.196409587709332 935 760008 SGTC_2605 digitonin 300 nM 0.854229647823159 0.206501731489018 no 720 0.19648887949909 1055 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3241 9133421 49.47 µM 0.854198015319948 0.206510669087555 no 721 0.196497641339772 988 17018221 SGTC_2201 6605497 169.863 µM 0.853296677319804 0.206765433708288 no 722 0.196747401105331 973 670741 SGTC_1385 3091-4834 14.1 µM 0.851600371318058 0.207245401612568 no 723 0.197217966724579 922 4072814 SGTC_2243 6634756 200 µM 0.851365161133737 0.207312006049938 no 724 0.197283269173052 924 885676 SGTC_2159 5658611 73.75 µM 0.851063169960781 0.207397539405764 no 725 0.197367131498901 1009 793844 SGTC_1851 st056236 18.9 µM 0.849916110676867 0.20772261257009 no 726 0.197685863918049 1016 5393171 SGTC_1356 1502-0781 85.8 µM 0.849208240756874 0.2079233708821 no 727 0.19788271428151 931 567702 SGTC_2267 7931562 200 µM 0.847466269135119 0.208417897383806 no 728 0.198367640255799 873 934880 SGTC_566 0958-0068 16.5 µM 0.843709687020071 0.209486707569652 no 729 0.19941582653448 923 6815365 SGTC_338 4055-0136 114 µM 0.843605300793323 0.209516453163195 no 730 0.19944500060218 1001 2900563 SGTC_3252 9135871 49.47 µM 0.841356194359068 0.210157955220054 no 731 0.200074209162761 982 17682838 SGTC_1864 st057645 30.4 µM 0.840849392820658 0.210302666957546 no 732 0.200216156197461 1012 688666 SGTC_2826 7992541 19.48 µM 0.840579998657272 0.210379613379641 no 733 0.200291633838302 1022 2985066 SGTC_2414 st077232 92.9 µM 0.840249977244541 0.21047389914354 no 734 0.200384121044992 911 729801 SGTC_1033 k072-0102 21.3 µM 0.840047091682031 0.210531875025113 no 735 0.200440991659965 986 5965931 SGTC_573 3702-0553 84.7 µM 0.83990428584711 0.21057268834956 no 736 0.20048102720949 957 1222756 SGTC_925 2064-1272 59.6 µM 0.839637369634197 0.210648984360903 no 737 0.200555869921949 916 6815817 SGTC_1699 st031318 29.054 µM 0.8392888983485 0.21074861668811 no 738 0.200653605741662 1020 5340658 SGTC_214 4373-3496 70 µM 0.839106964794207 0.210800644762624 no 739 0.200704644046003 1116 3779166 SGTC_758 0868-0029 16 µM 0.838271572690802 0.211039640995599 no 740 0.200939098844641 1024 762687 SGTC_2023 5144124 124 µM 0.835513424834355 0.211829842947037 no 741 0.201714345707632 973 2830192 SGTC_1056 3448-1962 115 µM 0.831903074841549 0.212866810226138 no 742 0.202731828062796 943 715507 SGTC_2476 5806916 10.51 µM 0.831061550051042 0.213108938660273 no 743 0.202969429708263 955 2870194 SGTC_1449 4112-4002 201 µM 0.830099900101741 0.213385826800863 no 744 0.203241151791403 925 2059539 SGTC_2137 5261020 140 µM 0.829724568039055 0.213493953140924 no 745 0.203347263823387 972 763655 SGTC_282 k297-0036 65.7 µM 0.826897065079992 0.214309531033306 no 746 0.204147703531915 987 5061378 SGTC_1075 aripiprazole 15.2 µM 0.826284645475063 0.214486418616476 no 747 0.204321320739158 1055 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2423 st077119 87.2 µM 0.826224935065382 0.21450366955139 no 748 0.204338252976658 1006 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2133 5320837 200 µM 0.825223099538734 0.214793230148662 no 749 0.204622470678481 940 2841355 SGTC_1979 st071809 45.3 µM 0.820291888353562 0.216221804516781 no 750 0.206024864749566 1026 4976333 SGTC_2870 9038528 12.99 µM 0.819153568242116 0.216552356268059 no 751 0.20634940112982 931 6463316 SGTC_1280 0880-0253 10.1 µM 0.816528645562454 0.217315709387397 no 752 0.20709892341679 996 6836607 SGTC_2296 7971656 126.45 µM 0.8159916903843 0.217472052420434 no 753 0.207252444169665 1011 666570 SGTC_681 1642-0006 26.6 µM 0.815982379124589 0.217474764114276 no 754 0.207255106943663 1027 4446530 SGTC_2172 5754775 163.918 µM 0.814550721052237 0.217891934320576 no 755 0.207664763936629 947 2263357 SGTC_2310 7668677 200 µM 0.813314307728598 0.218252583330674 no 756 0.208018937952518 1003 2197143 SGTC_3268 9137683 49.47 µM 0.813155231439694 0.21829900920257 no 757 0.208064531671381 1001 1953228 SGTC_3192 9110362 49.47 µM 0.81260631492978 0.218459252294004 no 758 0.208221904900568 1055 16649480 SGTC_2354 9060492 162 µM 0.812411179775197 0.218516233668179 no 759 0.208277866663509 1054 6471895 SGTC_2663 amphotericin b 100 µM 0.811853709557599 0.218679067565959 no 760 0.208437789429976 1030 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_429 1112-0049 25.5 µM 0.809208496790918 0.219452670582088 no 761 0.209197614179777 940 2836170 SGTC_2018 5133068 143 µM 0.80918216500754 0.219460379312226 no 762 0.20920518604647 960 785362 SGTC_2987 9018338 71.43 µM 0.809090970477035 0.219487078061591 no 763 0.209231410843031 1032 5055682 SGTC_3175 9106517 49.47 µM 0.808718607572809 0.219596112994837 no 764 0.209338511264601 999 41468073 SGTC_2884 9058502 51.95 µM 0.80817138627668 0.219756406223485 no 765 0.209495963648777 1033 6471554 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.806801396705651 0.22015800094335 no 766 0.20989045716699 1052 4213774 SGTC_1247 0448-0043 5.84 µM 0.803742596700836 0.22105616596935 no 767 0.210772823927801 1042 3089013 YGL099W LSG1 SGTC_680 0417-1641 114 µM 0.80277109191902 0.221341870119401 no 768 0.211053526841878 980 2835990 SGTC_1203 3992-3522 103 µM 0.802605788815437 0.221390504154157 no 769 0.211101310699717 1087 5322312 SGTC_3289 9119912 71.43 µM 0.800404935414755 0.222038601988844 no 770 0.211738111216083 1037 17014829 SGTC_2961 9083290 32.55 µM 0.799311983667532 0.222360851785791 no 771 0.212054765949516 1000 17741490 SGTC_1079 idarubicin 2.36 µM 0.799160020958963 0.222405678129661 no 772 0.212098815164233 1013 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2922 7999257 32.47 µM 0.798008201798297 0.222745612204995 no 773 0.212432865272221 987 2988377 SGTC_2470 5664817 21.68 µM 0.795874573911229 0.223376087133722 no 774 0.213052470566363 1054 2859561 SGTC_545 4218-0007 221 µM 0.793806281526489 0.22398822388536 no 775 0.21365410761804 1003 2840508 SGTC_2364 9055074 200 µM 0.793594948739947 0.224050824062563 no 776 0.213715637024312 1037 6470630 SGTC_630 4356-0227 183 µM 0.792994199936522 0.224228829810828 no 777 0.21389060101814 1052 779312 SGTC_3099 9120367 49.47 µM 0.7924648826733 0.224385736458084 no 778 0.21404483015421 1061 24824940 SGTC_2324 6149169 200 µM 0.79197577996794 0.224530777599494 no 779 0.214187399345565 1017 2888231 SGTC_2815 7968870 71.43 µM 0.790338112090242 0.225016807473668 no 780 0.214665167341904 1069 2977326 YHR190W ERG9 SGTC_2473 5854593 8.94 µM 0.790317929496706 0.225022801015116 no 781 0.214671059208185 1002 2872951 SGTC_2047 4141938 200 µM 0.789306637042718 0.225323236174041 no 782 0.214966404212321 999 3807862 SGTC_2519 cryptotanshinone 88.04 µM 0.788041843181662 0.225699301116374 no 783 0.215336115480707 1053 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2873 9040596 71.43 µM 0.786885475083985 0.226043438016173 no 784 0.215674455498807 1084 6463863 SGTC_2164 5685496 200 µM 0.786736432946456 0.226087814750137 no 785 0.215718085926767 1073 759046 SGTC_2840 9008771 71.43 µM 0.785717753721971 0.226391254450173 no 786 0.216016429907442 1030 2992978 SGTC_3097 9117246 49.47 µM 0.785215084037667 0.226541072200265 no 787 0.216163736485246 1118 16423892 SGTC_3122 9126309 49.47 µM 0.782183692846891 0.227445746199726 no 788 0.217053313322013 1143 17591206 SGTC_2003 4023581 200 µM 0.781618583024238 0.227614619646112 no 789 0.21721938124105 1054 16641307 SGTC_3201 9113999 49.47 µM 0.78073859200563 0.227877730479798 no 790 0.217478128865254 1014 16649224 SGTC_1697 st025554 27.742 µM 0.779882339339709 0.228133907904729 no 791 0.217730067298837 1072 1269519 SGTC_1896 st058441 89 µM 0.777715738303297 0.228782843834015 no 792 0.218368305962437 981 688759 SGTC_2614 arthonioic acid 13.39 µM 0.774614352053553 0.229713565488173 no 793 0.219283787032403 1057 6710684 SGTC_2971 9092186 9.93 µM 0.772531949254452 0.230339679671793 no 794 0.219899715838526 1011 25236400 SGTC_1594 piperine 70.1 µM 0.772354206727387 0.230393165522531 no 795 0.219952334105371 1061 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_72 0744-0168 198.391 µM 0.772196042380024 0.230440765792776 no 796 0.219999162591605 1026 677577 SGTC_1995 st072814 61.1 µM 0.771932181606725 0.230520188111443 no 797 0.220077297861907 1029 5769371 SGTC_722 3534-0461 190 µM 0.770277050931139 0.231018732679383 no 798 0.220567783254864 1103 658262 SGTC_546 peri-Naphthalide 147 µM 0.768957784397091 0.231416541731084 no 799 0.220959186034833 1055 223824 A penicillin ester. SGTC_2420 aureobasidin a 50 nM 0.765880894962797 0.232345823628791 no 800 0.221873587326355 1103 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2369 9071472 200 µM 0.765406013766627 0.232489431901643 no 801 0.222014906527932 1089 17296037 SGTC_779 1360-0071 233 µM 0.764384665525384 0.232798463817273 no 802 0.222319022114179 1158 7566 SGTC_2766 oltipraz 83.91 µM 0.763499469991305 0.233066484195925 no 803 0.222582789150349 1053 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2033 5192550 145 µM 0.763399196623199 0.233096855865529 no 804 0.222612679454793 1096 182073 SGTC_1224 0823-0416 294 µM 0.762594014174916 0.233340816178369 no 805 0.222852777759194 1101 3598164 SGTC_765 1319-0117 244 µM 0.762349645644301 0.23341488483173 no 806 0.222925675472958 1096 3487746 YGL099W LSG1 SGTC_3074 9116018 49.47 µM 0.76223779290092 0.233448792001769 no 807 0.222959046858894 1114 17027303 SGTC_3344 9148862 3.898 µM 0.75904613801718 0.234417464443492 no 808 0.22391247877825 1108 4905352 SGTC_1036 k216-0215 33.5 µM 0.758876921196392 0.234468884033492 no 809 0.2239630929201 1091 622330 SGTC_2005 4024620 188 µM 0.758616017825661 0.234548176465481 no 810 0.224041143999369 1104 236743 SGTC_1777 st045864 34.765 µM 0.758192930901616 0.234676790425052 no 811 0.224167746269667 1099 4691462 SGTC_1970 st070122 35.8 µM 0.758081237571198 0.234710750524065 no 812 0.224201175562343 1116 102928 SGTC_3032 9089427 49.47 µM 0.755250655581652 0.235572288820135 no 813 0.225049299914087 1091 17173707 SGTC_1911 st060208 74.3 µM 0.754941212333219 0.235666579083328 no 814 0.225142128185322 1105 688783 SGTC_1628 st004252 77.7 µM 0.754382334721676 0.235836927072538 no 815 0.225309837929571 1097 692968 SGTC_2536 dehydroabietamide 32.04 µM 0.754028250324771 0.235944888441147 no 816 0.225416129283652 1124 3983547 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.752616235532525 0.236375686654914 no 817 0.225840279265778 1153 688751 SGTC_2016 5121758 140 µM 0.751541185631435 0.23670396879924 no 818 0.226163512002709 1149 2795203 SGTC_1796 st049173 110.4 µM 0.750966851780742 0.236879452727594 no 819 0.226336302698161 1073 94134 SGTC_1330 1469-0054 61.8 µM 0.748572714251942 0.23761173565201 no 820 0.227057391525736 1146 7102664 SGTC_1196 1588-0294 184 µM 0.748426833209373 0.23765639567597 no 821 0.227101371175582 1066 6144269 SGTC_1523 st012844 44.7 µM 0.747458519054344 0.237952952093331 no 822 0.227393416467964 1104 4274103 SGTC_2485 5633444 17.78 µM 0.745137701093693 0.238664552180932 no 823 0.22809423985052 1095 5724239 SGTC_942 3253-1115 227 µM 0.744798502333938 0.238768653420694 no 824 0.228196770213192 1135 46497897 SGTC_293 4049-0273 38.5 µM 0.744078717520535 0.238989640060189 no 825 0.228414426974434 1058 1380311 SGTC_2102 5377816 72.7585 µM 0.743712460120895 0.239102130458093 no 826 0.22852522483938 1151 1379702 SGTC_965 1291-5240 308 µM 0.742652325513074 0.239427897759777 no 827 0.228846100140906 1104 2834598 SGTC_2875 9039966 71.43 µM 0.741942112764576 0.239646273566082 no 828 0.229061204531408 1154 6463691 SGTC_1154 4088-0362 150 µM 0.741345129452833 0.239829917710381 no 829 0.229242102468584 1170 6618304 SGTC_1651 st011928 86.1 µM 0.739921460012591 0.240268176910215 no 830 0.229673826047748 1105 720198 SGTC_775 4577-0580 57.3 µM 0.739835274592485 0.240294722037332 no 831 0.229699976134043 1154 2006902 SGTC_1736 st036774 51 µM 0.73786356313425 0.240902445792476 no 832 0.230298681359838 1166 1272247 SGTC_1077 5-fluorocytosine 377 nM 0.737673130539548 0.240961185443998 no 833 0.230356551914357 1084 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.737423459719703 0.241038209149348 no 834 0.230432436687839 1137 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3056 9094900 49.47 µM 0.737049815301079 0.241153503843671 no 835 0.230546028011496 1089 25236784 SGTC_2692 st077426 47.7 µM 0.736638555321884 0.241280440144602 no 836 0.230671090979459 1147 25238571 SGTC_1622 st003707 19.4 µM 0.736111002767542 0.241443323552711 no 837 0.230831573662569 1133 10140899 SGTC_1084 voriconazole 435 nM 0.734337859617007 0.241991224211104 no 838 0.231371424549694 1156 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1176 0848-0131 83.3 µM 0.734131947720648 0.242054894595133 no 839 0.231434162053072 1202 6769040 SGTC_740 k014-0057 261 µM 0.73206062042424 0.24269587843599 no 840 0.232065784101116 1141 4012779 SGTC_2278 7948257 134.34 µM 0.729943631558574 0.243351940846001 no 841 0.232712320396105 1120 1247028 SGTC_343 4130-2827 29.8 µM 0.729864150022573 0.243376591110784 no 842 0.232736613836345 1155 1118244 SGTC_1610 st001799 48.1 µM 0.729709254338653 0.243424634064394 no 843 0.232783961573767 1048 621897 SGTC_1102 cgs 12066b 26.1 µM 0.728820704930253 0.243700328442282 no 844 0.233055672301925 1099 6438352 A 5-HT1B full agonist. SGTC_696 1560-0013 611 µM 0.728164695356018 0.243903979722241 no 845 0.233256387310672 1178 1650269 SGTC_3302 9125395 16.351 µM 0.726260703870226 0.244495573559837 no 846 0.233839482229417 1110 17599668 SGTC_702 1488-0190 94 µM 0.724932444922685 0.24490873743984 no 847 0.234246737642523 1154 949357 SGTC_1349 flufenamic acid 69 µM 0.724584344253882 0.245017078595755 no 848 0.234353533145133 1120 3371 A non-steroidal anti-inflammatory. SGTC_3130 9127414 49.47 µM 0.724171058120916 0.245145741228143 no 849 0.234480362193699 1194 1494646 SGTC_1803 st050068 52.4 µM 0.724076309320887 0.245175243175163 no 850 0.234509444009469 1234 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1931 st074438 57.1 µM 0.723238086014389 0.245436324018897 no 851 0.2347668117923 1135 2787313 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.723011044082098 0.245507066319245 no 852 0.234836549531394 1068 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_801 0866-0028 10.1 µM 0.722435623034427 0.245686406520025 no 853 0.235013345965589 1195 6849771 SGTC_1850 st056238 17 µM 0.722228974793761 0.245750829282727 no 854 0.235076855974762 1180 5393177 SGTC_2522 biochanin a 4.94 µM 0.720384671104345 0.246326193971172 no 855 0.235644092695514 1122 5280373 A possible chelator. SGTC_742 0kpi-0133 140 µM 0.720189892105172 0.246387001016463 no 856 0.235704043251782 1166 2728852 SGTC_1193 1488-0126 41.5 µM 0.718738691001421 0.2468402971099 no 857 0.236150969608512 1207 1384710 SGTC_1341 1486-1360 280 µM 0.718319983516574 0.246971167200124 no 858 0.236280005656652 1167 3976547 SGTC_374 0880-0231 82.3 µM 0.718195231464677 0.247010166545147 no 859 0.236318458884963 1141 6833587 SGTC_2505 galangin 7.89 µM 0.71785816907971 0.247115553730899 no 860 0.236422371294176 1058 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1726 st035556 14.5795 µM 0.717199459332659 0.247321577790848 no 861 0.23662551642451 1169 5919439 SGTC_1287 0971-0001 34.6 µM 0.715792274705606 0.24776200909708 no 862 0.237059811643869 1157 4665869 SGTC_2329 6138490 200 µM 0.714824025382351 0.248065302142186 no 863 0.237358893766234 1080 720019 SGTC_2170 morpholine 200 µM 0.713842074276004 0.248373089290903 no 864 0.237662419716844 1166 121171 Reacts with secondary amines. SGTC_2248 tofa 1.1 µM 0.71274045512834 0.248718627859795 no 865 0.238003188965053 1111 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1034 k072-0165 12.7 µM 0.712035635818754 0.248939838710607 no 866 0.238221354599304 1178 5835461 SGTC_2964 9083345 53.42 µM 0.711988099434026 0.248954761996454 no 867 0.238236072675757 1142 17741579 SGTC_955 1216-0110 33 µM 0.70932302217743 0.249792181288551 no 868 0.239062022464133 1144 3619719 SGTC_1717 st033143 58.0435 µM 0.7088605839417 0.249937640527515 no 869 0.239205498621903 1181 674616 SGTC_2322 7413319 38.22 µM 0.708683324086918 0.249993409259543 no 870 0.23926050776375 1192 1840400 SGTC_5 0352-0601 109.883 µM 0.707571554040834 0.250343340093458 no 871 0.239605681497538 1104 762456 SGTC_3290 9121031 71.43 µM 0.707566777201246 0.250344844168959 no 872 0.239607165159838 1149 17014854 SGTC_1212 0520-0165 585 µM 0.703960813473173 0.251481613355832 no 873 0.240728588808978 1258 5403258 SGTC_3139 9095020 49.47 µM 0.703168220643263 0.251731841020169 no 874 0.240975460707634 1010 25236292 SGTC_3356 9151811 4.48 µM 0.702666196203402 0.251890401990429 no 875 0.241131899364467 1170 1859254 YPR165W RHO1 SGTC_2603 homopterocarpin 100 µM 0.701190803914581 0.252356699459204 no 876 0.241591974034801 1200 101795 A weak amylase inhibitor. SGTC_1973 st070275 50.2 µM 0.701004101065435 0.252415739278313 no 877 0.241650227929856 1135 17118334 SGTC_2838 9002687 71.43 µM 0.700079138653129 0.252708341422307 no 878 0.241938941551834 1179 6457060 SGTC_1440 4100-1550 40 µM 0.698796998708496 0.253114228136227 no 879 0.242339452226119 1211 742806 SGTC_637 1181-0519 7.26 µM 0.697636446396306 0.253481919346003 no 880 0.2427022913112 1217 6252091 YGR060W ERG25 SGTC_1008 4106-0037 6 µM 0.697301224060401 0.253588178157664 no 881 0.242807151096251 1175 2905394 SGTC_1314 1222-0010 41.1 µM 0.696535663215561 0.253830933423921 no 882 0.243046715548282 1199 3526027 SGTC_1227 3909-8010 46.6 µM 0.695441886578624 0.254177975703498 no 883 0.243389209173439 1169 15982272 SGTC_1145 3546-0597 10.2 µM 0.693738747091646 0.254718856527887 no 884 0.243923031004749 1169 875334 SGTC_2701 st077767 14.721 µM 0.693439087599292 0.25481408430828 no 885 0.244017019790653 1212 5721188 SGTC_878 0828-0289 13.7 µM 0.693081685922198 0.254927686147289 no 886 0.244129145066136 1193 745350 YLR208W SEC13 SGTC_1226 3909-7979 35.4 µM 0.692415263961561 0.255139582329551 no 887 0.244338291422558 1207 6615510 SGTC_669 0108-0021 26.2 µM 0.692303442259002 0.255175146290685 no 888 0.244373394415329 1277 17201 SGTC_1922 5578187 25 µM 0.691901715896112 0.255302933396725 no 889 0.244499526498979 1204 1350412 SGTC_2448 5185112 27.17 µM 0.691713347616868 0.255362863903351 no 890 0.244558681528356 1195 5718189 SGTC_1919 st067113 52.3 µM 0.691197139492708 0.255527136314935 no 891 0.244720830632785 1192 1268243 SGTC_445 e6 berbamine 66 µM 0.691107153819847 0.255555778017941 no 892 0.244749102473709 1243 6610268 A calcium/calmodulin antagonist. SGTC_866 0495-0101 262 µM 0.68875099930386 0.25630631911337 no 893 0.24548998820669 1179 635694 SGTC_1467 k284-1082 293 µM 0.688264116290468 0.256461556351385 no 894 0.245643237200382 1194 3334705 SGTC_451 chloral hydrate 100 µM 0.687816285102852 0.256604385587212 no 895 0.245784239775231 1271 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2694 st077685 81.9 µM 0.686828039859591 0.256919718530102 no 896 0.24609554892112 1194 2838096 SGTC_3264 9137442 49.47 µM 0.684394913091026 0.257696948054937 no 897 0.246862913663859 1237 17015726 SGTC_2437 5741531 144.16 µM 0.684075695366052 0.25779900835462 no 898 0.246963684186843 1272 2262990 SGTC_54 0159-0055 9 µM 0.68335316233567 0.258030094090796 no 899 0.247191854395774 1249 3319099 SGTC_1198 1612-1005 86.7 µM 0.681708204362754 0.258556596876582 no 900 0.247711739302682 1274 6998509 SGTC_2723 salbutamol 83.58 µM 0.680660370101645 0.258892267715294 no 901 0.248043208912367 1195 9884233 β2-adrenoceptor agonist SGTC_1649 st011737 51.3 µM 0.677943272222952 0.259763731693815 no 902 0.248903830971494 1201 1761035 SGTC_2444 5485484 36.41 µM 0.676953118173909 0.260081683066395 no 903 0.249217850115499 1267 6790631 SGTC_763 3453-1109 128 µM 0.676702874577311 0.260162071297836 no 904 0.249297246134375 1236 1560353 SGTC_1425 4048-4433 7.33 µM 0.675914811843874 0.260415312148892 no 905 0.249547366515058 1275 23734946 SGTC_1393 3470-5649 58.2 µM 0.67427317844903 0.260943251980643 no 906 0.250068826453785 1166 4108395 SGTC_3125 9127534 49.47 µM 0.673861966215358 0.26107558161385 no 907 0.250199537271112 1121 1639235 SGTC_676 falcarinol 140 µM 0.672764089580954 0.26142905133941 no 908 0.250548693504967 1268 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2720 fluspirilene 36.88 µM 0.672144515647562 0.261628636296946 no 909 0.250745849664178 1207 3396 An atypical antipsychotic. SGTC_703 3875-0075 71.8 µM 0.671060410836282 0.261978049819225 no 910 0.251091022882215 1274 2850814 SGTC_1986 st071812 45 µM 0.667847303583683 0.263015057199965 no 911 0.252115533913737 1223 11838594 SGTC_1060 3448-7350 82 µM 0.666970929520579 0.263298264382711 no 912 0.252395351243646 1209 570178 SGTC_655 k060-0012 42 µM 0.663702338410443 0.264355907174374 no 913 0.253440421212845 1209 5994525 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.663102536326822 0.264550224268649 no 914 0.253632443184584 1271 279621 SGTC_1312 1218-2183 165 µM 0.66271476482855 0.264675888758533 no 915 0.253756625872116 1263 6744073 SGTC_2352 9027995 87.8 µM 0.66162385690307 0.265029580312467 no 916 0.254106157107213 1224 2997347 SGTC_2954 9074818 52.69 µM 0.661349612521039 0.265118532924198 no 917 0.254194065803093 1254 16648742 SGTC_2088 5278280 127.392 µM 0.661285956056609 0.26513918240234 no 918 0.254214473083967 1286 791502 SGTC_2336 9001819 198.65 µM 0.657797204578997 0.266272143908764 no 919 0.255334225452771 1314 2989602 SGTC_2251 lansoprazole 556 µM 0.657509745942445 0.2663656043835 no 920 0.255426603225525 1175 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1352 1496-0991 99 µM 0.657231385891636 0.266456122481727 no 921 0.25551607371613 1248 3000039 SGTC_1641 st009299 47.1 µM 0.656222131728516 0.266784445726985 no 922 0.255840605445128 1215 4046054 SGTC_1177 0983-0204 23.6 µM 0.655695188603434 0.266955948244083 no 923 0.256010132613432 1277 766818 SGTC_1665 st014639 11.4 µM 0.654612690381096 0.267308440142425 no 924 0.256358575702524 1315 981133 YIL048W NEO1 SGTC_1824 st053723 68.6 µM 0.650923397237761 0.268511539243203 no 925 0.257547968546115 1240 675225 SGTC_1629 st005085 44.9 µM 0.650830372381753 0.268541910315674 no 926 0.257577995872104 1259 24207091 SGTC_693 4161-2696 114 µM 0.648779441242512 0.269211943707949 no 927 0.258240473865868 1299 805759 SGTC_2819 7996655 46.38 µM 0.648597738300346 0.269271345959276 no 928 0.258299208888727 1177 6456960 SGTC_674 0498-0004 451 µM 0.648507984903108 0.269300690528456 no 929 0.258328224004808 1238 4231473 SGTC_588 3970-1144 52.9 µM 0.64457735626699 0.270587367133091 no 930 0.259600556404246 1207 1888707 SGTC_1862 st057513 3.81 µM 0.637491499382464 0.272914626656894 no 931 0.261902372630479 1261 5393163 SGTC_611 3453-1652 23.7 µM 0.636439250361939 0.273261069026026 no 932 0.262245082446547 1293 1560575 SGTC_2299 7976368 114.88 µM 0.63534982601211 0.27361998037765 no 933 0.262600141889995 1296 2979718 SGTC_226 1,3-diallylurea 8.28947 mM 0.635268439652122 0.27364680251196 no 934 0.262626676775748 1248 74537 YKL182W FAS1 SGTC_1089 terbinafine 2.25 µM 0.635112782152243 0.273698105472683 no 935 0.262677430550275 1293 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2495 cafestol 54.53 µM 0.633802853856808 0.274130031506112 no 936 0.263104745248966 1310 16667697 An anti-infammatory. SGTC_577 r071-0003 38.6 µM 0.633392221933206 0.274265499518616 no 937 0.263238771514582 1324 4568517 YMR134W ERG29 SGTC_1004 4084-0029 199 µM 0.633189258507277 0.27433246962562 no 938 0.263305029678082 1309 716894 YLR208W SEC13 SGTC_59 0330-0160 1.33 µM 0.63135431679988 0.274938295829901 no 939 0.263904439516637 1289 4293482 SGTC_3223 9129970 49.47 µM 0.629452819047821 0.275566790991969 no 940 0.2645263238971 1359 17248386 SGTC_3078 9116413 49.47 µM 0.627918408809757 0.276074468614819 no 941 0.265028695446089 1238 17177322 SGTC_418 lividomycin a 100 µM 0.62749313115172 0.276215257946043 no 942 0.265168018653068 1298 72394 An antibiotic. SGTC_55 0767-0285 6.563 µM 0.626811610508445 0.276440950668517 no 943 0.265391365950718 1267 3116166 SGTC_2851 9015922 71.43 µM 0.626068605462519 0.276687107592995 no 944 0.265634971589762 1326 2996893 SGTC_3188 9110789 49.47 µM 0.625409112107108 0.276905687105426 no 945 0.26585129158979 1334 849217 SGTC_754 3474-0146 171 µM 0.625124266606884 0.277000121157175 no 946 0.265944751182292 1232 24762078 SGTC_819 1013-0258 27.7 µM 0.624793416955865 0.277109826625771 no 947 0.26605332591675 1297 5753198 SGTC_1829 berberine 14.4 µM 0.622095195435362 0.278005314934016 no 948 0.266939637017719 1368 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_152 4469-0003 551.229 µM 0.621244508792202 0.278287934099209 no 949 0.267219379251253 1298 697280 SGTC_359 0081-0058 15.9 µM 0.62082978286278 0.278425767089487 no 950 0.267355812542339 1440 3494159 SGTC_186 3455-3465 67.277 µM 0.6197370078723 0.278789106993206 no 951 0.267715473316685 1260 755278 SGTC_290 2043-6722 48.1 µM 0.61886725809377 0.27907845743752 no 952 0.268001904824055 1315 773758 YLR208W SEC13 SGTC_1240 0356-0016 42.1 µM 0.618039269404827 0.279354050311357 no 953 0.268274726593561 1320 4305613 SGTC_2271 7849410 118.62 µM 0.615962233055856 0.280045965201315 no 954 0.26895972308509 1312 972430 SGTC_2636 apigenin dimethyl ether 100 µM 0.615314894734349 0.280261780122878 no 955 0.269173391446761 1325 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.614940207995905 0.280386733038236 no 956 0.269297104008422 1346 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1709 st033179 39.1045 µM 0.613768184295013 0.280777761010534 no 957 0.269684262088213 1299 573381 SGTC_2907 7721985 69.9 µM 0.61344985452876 0.280884012440859 no 958 0.269789465033409 1274 3267881 SGTC_302 1094-0063 18.9 µM 0.613412089010301 0.280896619024653 no 959 0.269801947302498 1269 5440289 SGTC_439 amiodarone 34.4 µM 0.613186382597839 0.280971968238212 no 960 0.269876553873317 1286 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2990 9074105 71.4286 µM 0.612861481953808 0.28108044933094 no 961 0.269983966927089 1305 6502001 SGTC_3167 9103034 49.47 µM 0.612063026607467 0.281347131558375 no 962 0.27024802934004 1323 5127859 SGTC_358 0075-0058 9.45 µM 0.609661551835435 0.282149953766063 no 963 0.271043014353858 1367 1069125 SGTC_1381 2324-0066 62.1 µM 0.609581011978631 0.282176897650217 no 964 0.271069696498199 1340 10885928 SGTC_403 arphamenine a 50 µM 0.609225198415009 0.282295946695268 no 965 0.27118759007042 1289 5487158 An arginine aminopeptidase inhibitor. SGTC_2756 carbadox 75.1 µM 0.608917489409917 0.282398920272838 no 966 0.271289565516647 1316 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3184 9108758 49.47 µM 0.608646795842553 0.282489521718859 no 967 0.271379289764093 1328 902885 SGTC_1794 st048918 76.9 µM 0.608430101076215 0.282562059776168 no 968 0.271451126192048 1283 672303 SGTC_1490 4089-0339 670 nM 0.607080072683068 0.283014180128136 no 969 0.271898887009068 1297 742542 SGTC_1833 st055984 71 µM 0.607068640878797 0.283018010086452 no 970 0.2719026801376 1329 676288 SGTC_2646 retinol 96.75 µM 0.607024728599931 0.283032722098497 no 971 0.271917250691119 1334 445354 A vitamin A analog and teratogen. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.605878978542149 0.283416714543552 no 972 0.272297559767372 1303 61125 An anti-inflammatory. SGTC_2845 9003024 42.97 µM 0.604478120542891 0.283886544220057 no 973 0.272762905695776 1419 2990173 SGTC_1634 st006576 41 µM 0.60390754777726 0.284078013737847 no 974 0.272952555204187 1349 3915356 SGTC_79 0052-0007 94.094 µM 0.60389600066306 0.284081889289447 no 975 0.272956393960139 1384 2801472 SGTC_414 piperonyl butoxide 100 µM 0.59892115139376 0.285753943212031 no 976 0.274612732957272 1305 5794 A potent inhibitor of cytochrome P450. SGTC_1975 st070967 30.8 µM 0.598174399396045 0.286005331122633 no 977 0.274861785742901 1346 261391 SGTC_1120 ficusin 1.78878 µM 0.597583585851786 0.286204298081275 no 978 0.275058909608043 1447 6199 A DNA cross-linker. SGTC_1558 st069300 45.6 µM 0.591299183081016 0.288324740201089 no 979 0.277159988426531 1342 24208000 SGTC_1262 0737-0114 49.6 µM 0.590709940225014 0.288523937919823 no 980 0.277357393273214 1369 765919 SGTC_2114 5491910 81.25 µM 0.590442183144859 0.288614476520293 no 981 0.277447118465013 1420 2849228 SGTC_3038 9091290 49.47 µM 0.590243633137327 0.288681622282898 no 982 0.277513661580226 1395 25236843 SGTC_2835 9006588 71.43 µM 0.589327859076097 0.288991414493764 no 983 0.277820679926931 1359 2345538 SGTC_2808 7946468 45.46 µM 0.589009348767675 0.289099198254738 no 984 0.277927501134775 1386 2970879 SGTC_1211 1056-0033 32.3 µM 0.587401330723696 0.289643639356434 no 985 0.278467100153892 1360 6741922 SGTC_477 mead ethanolamide 10 µM 0.586535058729022 0.289937140180237 no 986 0.278758004514763 1275 16061185 SGTC_2803 7707263 71.43 µM 0.585927924630881 0.29014292581881 no 987 0.278961975440331 1356 2199229 SGTC_2897 9048598 12.99 µM 0.584262310127029 0.290707830249069 no 988 0.279521922726966 1333 6467404 SGTC_707 0865-0008 204 µM 0.582965448094201 0.291148025640665 no 989 0.279958280132594 1412 723043 SGTC_1915 st067105 30.6 µM 0.58002686930112 0.292146620850179 no 990 0.280948249179718 1335 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2103 5378138 10 µM 0.579524643636263 0.292317447783408 no 991 0.281117611621799 1401 244142 SGTC_2586 curcumin 80 µM 0.578777129526479 0.292571793070047 no 992 0.281369782452554 1415 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1163 k060-0048 49.9 µM 0.578598862526674 0.29263246446019 no 993 0.281429936215081 1363 6809982 SGTC_1322 1348-1070 12 µM 0.577240727715529 0.293094883830001 no 994 0.281888423860569 1354 6758089 SGTC_660 4031-1742 102 µM 0.576403002002718 0.293380282576582 no 995 0.282171407886511 1311 6738706 SGTC_3242 9133940 49.47 µM 0.572048395925816 0.294865892101785 no 996 0.283644594050426 1422 17248444 SGTC_1751 st044839 27.194 µM 0.57168371639468 0.294990462702051 no 997 0.283768134056694 1383 5291326 SGTC_286 k060-0067 22.9 µM 0.569956328803446 0.295580848849114 no 998 0.284353659195188 1343 5985051 SGTC_1811 st050069 61.5 µM 0.568636823382981 0.296032194755551 no 999 0.284801314884323 1382 3877702 SGTC_1522 st012842 45.6 µM 0.568488531354256 0.29608293883194 no 1000 0.284851645482399 1316 3491067 YOR116C RPO31 SGTC_68 0986-0284 82.829 µM 0.568217384470081 0.296175732954625 no 1001 0.284943684225072 1333 423278 YIL048W NEO1 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.567563032818077 0.296399725504967 no 1002 0.285165857303643 1389 97141 SGTC_3293 9120939 62.045 µM 0.563175854068283 0.297903511846573 no 1003 0.286657571586577 1418 934087 SGTC_778 3456-2434 196 µM 0.561600854699901 0.29844421917932 no 1004 0.287193998978208 1509 5539063 SGTC_1715 st032160 10.2275 µM 0.560891091728506 0.298688031218252 no 1005 0.287435891620876 1381 5289825 SGTC_156 3474-0145 5.642 µM 0.560072656654315 0.298969285777874 no 1006 0.287714940107178 1357 2265471 SGTC_2216 7189485 200 µM 0.559635974295414 0.299119400515126 no 1007 0.28786388093485 1408 731273 SGTC_1888 azatryptophan 97.5 µM 0.559410212889692 0.299197022088684 no 1008 0.287940896468246 1377 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2979 9012552 45.46 µM 0.559086563073823 0.299308315721957 no 1009 0.288051322312189 1434 17100905 SGTC_1843 st055809 45.5 µM 0.55760053560142 0.299819557653585 no 1010 0.288558595330606 1393 16413835 SGTC_2399 5884133 200 µM 0.555152397559879 0.300662658039449 no 1011 0.289395212799536 1393 722445 SGTC_3312 9133330 71.43 µM 0.554527312435143 0.300878098942165 no 1012 0.289609009520858 1458 17617324 SGTC_3155 9099265 49.47 µM 0.554093015091016 0.301027824193596 no 1013 0.289757595088705 1407 25236499 SGTC_1836 st055642 81 µM 0.554035818030164 0.301047545546521 no 1014 0.289777166507774 1332 8571 SGTC_2611 pyromycin 23.93 µM 0.548614419035454 0.302919462473107 no 1015 0.291635044218398 1377 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2533 agelasine 13.65 µM 0.547108341478271 0.303440408716462 no 1016 0.292152150930963 1525 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3329 9141233 27.5565 µM 0.54670957775045 0.303578406491791 no 1017 0.292289136534652 1494 4909101 YNL103W MET4 SGTC_395 anisomycin 6.25 µM 0.546675079653036 0.303590346358694 no 1018 0.292300988922941 1378 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3250 9135583 49.47 µM 0.544979301042105 0.30417751730414 no 1019 0.292883876885356 1476 7699353 SGTC_279 1273-0055 2.93 µM 0.54429641812304 0.304414111386 no 1020 0.293118755694977 1461 2847562 SGTC_2197 6588183 93.1375 µM 0.543795698757918 0.304587644459072 no 1021 0.293291034512639 1397 884136 SGTC_2781 5567276 71.43 µM 0.542564020294085 0.305014691345356 no 1022 0.293715008611265 1464 2853274 SGTC_556 4058-0063 51.5 µM 0.541793946128355 0.305281826064306 no 1023 0.293980231153019 1456 6615692 SGTC_1749 st037932 54.2 µM 0.539824380877915 0.305965529736201 no 1024 0.294659075721593 1421 594497 SGTC_3262 9137218 49.47 µM 0.539489621077042 0.306081803688371 no 1025 0.294774528302006 1337 17650664 SGTC_1271 0832-2808 169 µM 0.539367343397127 0.306124279936467 no 1026 0.294816704854812 1466 3663794 SGTC_1243 0416-0003 5.65 µM 0.538102565856245 0.306563785277317 no 1027 0.29525312057359 1417 2141977 SGTC_335 4077-0256 27.6 µM 0.536806138855835 0.307014577587227 no 1028 0.295700765402256 1439 3121989 SGTC_2111 5486399 200 µM 0.535437383789454 0.30749083653796 no 1029 0.296173722666849 1419 689674 SGTC_1927 st060202 13.8 µM 0.535024988187439 0.307634393468935 no 1030 0.296316289135585 1423 688887 SGTC_175 3793-3120 23.7 µM 0.534060598869581 0.307970217095386 no 1031 0.296649804358369 1422 5322297 SGTC_1236 0330-0013 258 µM 0.532311646882412 0.308579654674662 no 1032 0.297255083460697 1425 4617066 SGTC_1384 3089-0840 101 µM 0.531394898871019 0.308899314431954 no 1033 0.297572577843909 1513 1069836 SGTC_2374 9071832 200 µM 0.530399599938757 0.309246527963908 no 1034 0.297917451666636 1403 17381698 SGTC_2281 7943571 200 µM 0.529622125394147 0.309517871273258 no 1035 0.298186975438805 1491 1244024 SGTC_1427 4048-4900 550 nM 0.527531152565735 0.310248148442691 no 1036 0.298912394431357 1506 24132586 SGTC_1857 st056007 79.3 µM 0.527010621939272 0.310430061515681 no 1037 0.299093106121862 1435 619834 SGTC_1407 3909-7909 12.3 µM 0.52630323796342 0.310677349725668 no 1038 0.299338766821755 1424 4411780 SGTC_2942 9052777 62.25 µM 0.525929539229689 0.31080802236136 no 1039 0.299468582058465 1507 6469503 SGTC_1339 1486-1321 22.7 µM 0.525264749206478 0.31104054096129 no 1040 0.299699579471318 1443 3469382 SGTC_709 3807-1509 243 µM 0.525016347031095 0.311127442087025 no 1041 0.299785913538648 1475 1886677 YPL242C IQG1 SGTC_929 2805-0021 398 µM 0.523634380429041 0.311611102035348 no 1042 0.30026643202615 1488 3098024 SGTC_1607 st000305 50.6 µM 0.523082859697075 0.311804213811618 no 1043 0.300458296405511 1489 5457690 SGTC_700 3453-2283 142 µM 0.52290902532696 0.311865091634915 no 1044 0.300518781806982 1518 565664 SGTC_774 k060-0086 136 µM 0.522908800524031 0.311865170365557 no 1045 0.300518860030375 1483 5911235 SGTC_48 0382-0018 55 µM 0.519780584487662 0.31296156747766 no 1046 0.30160825657191 1571 762596 SGTC_3270 9137563 49.47 µM 0.519268835221196 0.31314108651359 no 1047 0.301786641420643 1490 17015724 SGTC_36 0335-0881 14.2 µM 0.519032249923616 0.313224094407402 no 1048 0.301869126022468 1455 23828853 SGTC_2642 cholecalciferol 100 µM 0.517760234274107 0.313670553699002 no 1049 0.302312783195991 1484 9821465 A vitamin D precursor, similar to steriods. SGTC_3079 9117512 49.47 µM 0.517410067720445 0.313793505103289 no 1050 0.302434966593921 1531 7185044 SGTC_246 cycloheximide 667 µM 0.515624880197952 0.314420646103833 no 1051 0.303058214873686 1399 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1057 3448-5381 134 µM 0.51540697940972 0.314497231952776 no 1052 0.303134328171259 1552 5497911 SGTC_528 3492-0019 172 µM 0.511524053871286 0.315863304517001 no 1053 0.304492074834123 1483 2869262 SGTC_3094 9117742 49.47 µM 0.511278096553662 0.315949921079156 no 1054 0.304578170059056 1403 17149698 SGTC_650 1328-0195 38 µM 0.508802483300049 0.316822297471054 no 1055 0.305445339293126 1464 2780821 SGTC_378 3970-0959 8.33 µM 0.508729087973054 0.316848176687593 no 1056 0.305471065248603 1477 6615653 SGTC_677 0929-0063 136 µM 0.507610241493343 0.317242793226245 no 1057 0.305863353430952 1436 1539583 SGTC_2855 9016525 58.44 µM 0.507388589682499 0.317320994381622 no 1058 0.305941095097905 1432 43811474 SGTC_2081 5214970 32.255 µM 0.506466058593214 0.31764656090683 no 1059 0.306264755511817 1546 2063512 SGTC_2806 7952793 58.44 µM 0.506228885339666 0.317730283516584 no 1060 0.306347989725509 1503 2972490 SGTC_130 0136-0219 337.655 µM 0.50498546998297 0.318169363945366 no 1061 0.306784520686173 1488 234244 SGTC_90 0870-0863 4.608 µM 0.504542441150627 0.318325870083769 no 1062 0.306940122923057 1453 1738164 SGTC_3005 9076496 71.4286 µM 0.504519834799794 0.318333856963653 no 1063 0.306948063742777 1496 21368410 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.504460095608125 0.318354963374833 no 1064 0.306969048465553 1577 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_427 1354-0053 47.3 µM 0.504128199567512 0.318472236064602 no 1065 0.307085645863654 1553 6813657 SGTC_1732 st034308 51.822 µM 0.502307487647781 0.319115892734047 no 1066 0.30772562151628 1447 830119 SGTC_53 0973-0023 39.979 µM 0.501890809538523 0.319263273262037 no 1067 0.307872165217724 1480 674768 SGTC_1023 4482-3888 16 µM 0.501794220610026 0.319297441188396 no 1068 0.307906139459217 1572 3303168 SGTC_1345 1488-0192 31.4 µM 0.501017901919245 0.319572116371269 no 1069 0.308179261996428 1519 658348 SGTC_1643 st009866 20.2 µM 0.500916270424321 0.319608082711068 no 1070 0.308215025607726 1493 3156273 YOR207C RET1 SGTC_3085 9117376 49.47 µM 0.500185056317433 0.319866901857127 no 1071 0.308472389827592 1543 16480349 SGTC_3203 9113543 49.47 µM 0.499479348053171 0.320116776192201 no 1072 0.308720866076896 1520 17018012 SGTC_1952 st077036 64.1 µM 0.498612744152474 0.32042373144294 no 1073 0.30902611267725 1467 2937007 SGTC_871 0574-0004 149 µM 0.497548318785869 0.320800924164151 no 1074 0.309401219067864 1492 9551173 SGTC_2489 cantharidin 73.42 µM 0.495966614468347 0.321361763037628 no 1075 0.309958982895371 1441 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_372 0155-0182 15.9 µM 0.494490179372176 0.321885643503106 no 1076 0.310480020156673 1519 771486 SGTC_1261 0712-0010 12.7 µM 0.491695769228542 0.322878147447558 no 1077 0.311467214776655 1577 2840123 SGTC_2744 captopril 92.04 µM 0.489513628879171 0.323654067197953 no 1078 0.312239054037139 1583 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1398 3558-0053 112 µM 0.487871098728063 0.324238620111495 no 1079 0.312820573461354 1467 4532369 SGTC_2355 9061122 103.12 µM 0.486826755673119 0.324610512358688 no 1080 0.313190553944088 1576 5302957 SGTC_1288 0973-0013 65.5 µM 0.486799525065519 0.324620211563706 no 1081 0.313200203477567 1545 4315430 SGTC_1118 chelidonine 707.474 nM 0.485835510190937 0.324963658313794 no 1082 0.313541897545258 1614 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3198 9112019 49.47 µM 0.485053937683344 0.32524221610476 no 1083 0.31381904261399 1537 45595555 SGTC_3120 9124077 49.47 µM 0.482491615138427 0.326156129787937 no 1084 0.314728376718118 1512 18774327 YGL155W CDC43 SGTC_2714 st079313 56.9 µM 0.482308191729531 0.326221592284319 no 1085 0.31479351443973 1501 2939799 SGTC_3256 9138902 49.47 µM 0.482163743330765 0.32627314864858 no 1086 0.314844815326796 1555 17228773 SGTC_1124 fisetin 1.16336 µM 0.481574009567335 0.326483670214235 no 1087 0.315054296492732 1491 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_428 3448-4153 16.5 µM 0.481041758372867 0.326673719269575 no 1088 0.315243410182258 1440 3834874 SGTC_638 3970-0837 4.09 µM 0.480904935384102 0.326722581441564 no 1089 0.315292032460387 1476 4118451 YLR208W SEC13 SGTC_2173 5763948 167 µM 0.480900899377461 0.326724022823802 no 1090 0.315293466769684 1506 2867177 SGTC_1590 st077108 57.8 µM 0.475894186328472 0.328514059791175 no 1091 0.317074882101526 1543 5489485 SGTC_2733 amorolfine 100 µM 0.475344020938183 0.328711000150436 no 1092 0.317270893660884 1573 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1192 1488-0095 21.4 µM 0.474787761922703 0.328910170193712 no 1093 0.31746912836384 1527 915875 SGTC_111 0083-0039 52.457 µM 0.474531773008852 0.329001844045578 no 1094 0.31756037304075 1474 759313 SGTC_1764 st044502 93.5 µM 0.473636937797097 0.32932238008606 no 1095 0.317879415129357 1493 8407 SGTC_2275 7947463 200 µM 0.473600476246984 0.329335443522726 no 1096 0.317892417899345 1499 1225414 SGTC_2915 7971052 15.16 µM 0.473374037942758 0.329416576455667 no 1097 0.31797317443487 1426 5741558 SGTC_1914 st062367 72.6 µM 0.472759779259008 0.329636706018722 no 1098 0.318192286092712 1501 978205 SGTC_1680 diphenhydramine 100 µM 0.471684267129779 0.330022275378432 no 1099 0.318576084270656 1511 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1396 3511-0007 98.6 µM 0.471268763382759 0.33017128119345 no 1100 0.318724409601301 1508 X1396 SGTC_1300 1094-0077 113 µM 0.470024031399834 0.330617821729218 no 1101 0.319168924206416 1479 5532636 SGTC_236 1509-0011 5.31 µM 0.469968774269832 0.330637650507149 no 1102 0.319188663486022 1546 3107280 SGTC_717 1532-0246 73.2 µM 0.46815856909716 0.331287497239438 no 1103 0.319835598902249 1497 9561992 SGTC_857 0438-0306 1.35 µM 0.467128950552056 0.331657347622709 no 1104 0.320203811232922 1535 4686136 SGTC_3035 9091303 49.47 µM 0.467083286525069 0.331673754451363 no 1105 0.32022014571333 1534 25237002 SGTC_1706 st031321 9.9705 µM 0.464370010050624 0.332649198122395 no 1106 0.321191336356407 1600 6103185 SGTC_1461 k072-0203 53.8 µM 0.464107563866884 0.3327436097925 no 1107 0.321285341423455 1463 5418714 SGTC_847 0342-0274 5.54 µM 0.463255088534244 0.333050350089627 no 1108 0.321590766814711 1631 18097 SGTC_547 1120-0019 610 nM 0.460782443003287 0.333940696472208 no 1109 0.322477349611077 1555 3676939 SGTC_1360 1598-0022 39.8 µM 0.459581530425388 0.334373457084859 no 1110 0.322908309369287 1616 761525 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.458930114360215 0.33460829340616 no 1111 0.323142176246509 1541 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2049 5262831 67.185 µM 0.457802667328869 0.335014892391016 no 1112 0.323547109659918 1550 763417 SGTC_1237 0330-0133 46.1 µM 0.457332237198503 0.335184604070785 no 1113 0.323716130989922 1519 X1237 YHR072W ERG7 SGTC_2865 9030313 51.95 µM 0.455660965542617 0.335787801485849 no 1114 0.324316897818816 1492 42562754 SGTC_899 1083-0020 478 µM 0.455519562602191 0.335838856252193 no 1115 0.324367748512803 1624 767123 SGTC_352 k048-0007 5.11 µM 0.454487623793156 0.336211538453341 no 1116 0.324738948864143 1531 6811911 SGTC_3124 9127567 49.47 µM 0.454442755335469 0.3362277462437 no 1117 0.324755092521012 1661 17592030 SGTC_1926 methyl fluorone black 53.6 µM 0.453090652841365 0.33671630763389 no 1118 0.325241732875481 1456 72721 Reacts with homocysteine. SGTC_1606 st000094 49.2 µM 0.452102097688581 0.337073681327349 no 1119 0.325597716286121 1638 1242210 SGTC_326 k292-0812 17.5 µM 0.450864651006045 0.337521239371052 no 1120 0.326043550964061 1628 3579357 SGTC_420 mitomycin C 81.9 mM 0.450577979733366 0.337624955076084 no 1121 0.32614687011805 1511 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_809 3998-0021 90 µM 0.450465216789492 0.337665755318088 no 1122 0.326187514652963 1581 715485 SGTC_927 2425-1185 123 µM 0.449980027102149 0.337841329934005 no 1123 0.326362421088473 1490 730375 SGTC_2040 5100729 123 µM 0.447328429573444 0.33880148076246 no 1124 0.327318971510734 1587 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_317 4495-0002 170 µM 0.445382197825302 0.339506884251069 no 1125 0.328021787532092 1534 15991618 SGTC_1197 1601-0112 267 µM 0.442710611014072 0.340476105578384 no 1126 0.328987533193993 1526 7350313 SGTC_597 k018-0003 82.8 µM 0.442341510916577 0.340610093949716 no 1127 0.329121048307215 1654 6786234 SGTC_885 0865-0106 16.8 µM 0.442289823200539 0.340628858902011 no 1128 0.329139747120189 1499 2793380 SGTC_3016 9080866 49.47 µM 0.440917058865382 0.341127377974506 no 1129 0.329636521695691 1517 17066299 SGTC_2083 5306046 65.942 µM 0.438758802304157 0.341911709138867 no 1130 0.330418157285966 1550 539837 SGTC_1875 nocodazole 6 µM 0.438249891303265 0.342096751890371 no 1131 0.330602572825314 1615 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_548 1436-0017 110 µM 0.43746819208014 0.342381055753811 no 1132 0.33088591952 1696 9677137 SGTC_1433 4060-0023 7.6 µM 0.437357133394825 0.342421455029122 no 1133 0.330926183420801 1602 3840627 SGTC_263 alizarin 107.927 µM 0.436469591520157 0.342744376547662 no 1134 0.331248028561403 1606 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_521 r062-0005 13.8 µM 0.435657305656762 0.343040017808935 no 1135 0.331542693263147 1562 2832033 SGTC_3083 9117465 49.47 µM 0.434890949125775 0.343319030657611 no 1136 0.331820792264585 1526 16420915 SGTC_974 1326-0144 138 µM 0.432851142245149 0.344062093504741 no 1137 0.332561458204205 1557 5411856 SGTC_907 3448-6986 75.5 µM 0.432838387066962 0.344066741872172 no 1138 0.332566091745772 1664 590582 SGTC_1871 st057448 67.3 µM 0.432592978031332 0.344156180832876 no 1139 0.33265524585043 1663 691747 SGTC_1692 fluoroquinolonic acid 71 µM 0.432393678459082 0.344228821683019 no 1140 0.332727655915275 1616 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2375 9072683 200 µM 0.430860504876996 0.344787825881748 no 1141 0.333284901203461 1724 16798029 SGTC_146 3448-8650 53.125 µM 0.430300067514765 0.344992249352974 no 1142 0.333488689001669 1606 2891488 YIL048W NEO1 SGTC_523 1934-0222 13.7 µM 0.428496582608821 0.345650390007588 no 1143 0.334144810528743 1560 1361595 SGTC_3112 9123419 49.47 µM 0.427409047227195 0.346047486970785 no 1144 0.334540709445479 1602 17015854 SGTC_2649 anisomycin 9.56 µM 0.427358798662581 0.346065838564554 no 1145 0.334559006039795 1583 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_683 panaxydol 45 µM 0.426611650642594 0.346338751816194 no 1146 0.33483110520419 1676 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1956 st077085 54 µM 0.426549463940471 0.346361470559811 no 1147 0.334853756502377 1567 24208685 SGTC_170 4197-0004 226 µM 0.424649116808922 0.347055992895771 no 1148 0.335546240974496 1645 218692 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.42408865707838 0.347260923109796 no 1149 0.335750578747434 1580 6708784 An antioxidant flavonoid SGTC_1441 4106-0040 13 µM 0.420724874160721 0.348491815657598 no 1150 0.336977997698237 1583 2904180 SGTC_1501 4491-0275 38.4 µM 0.419490051878246 0.348944069544647 no 1151 0.337429011802403 1679 5104718 SGTC_3237 9133362 49.47 µM 0.418410688123526 0.349339562583144 no 1152 0.337823436700992 1659 43845137 SGTC_1373 2887-0003 58.5 µM 0.418356092275974 0.349359571569255 no 1153 0.337843392044726 1583 776948 SGTC_191 3914-0123 66.505 µM 0.417279288123546 0.349754298051839 no 1154 0.338237068121483 1549 3144412 SGTC_1018 4259-0013 28.1 µM 0.413433240277447 0.351165476158753 no 1155 0.339644612529125 1635 6801262 SGTC_837 0091-0265 12.5 µM 0.412626473386318 0.351461753540313 no 1156 0.339940151107426 1576 759367 SGTC_1221 2958-7315 257 µM 0.412344848662607 0.351565198776066 no 1157 0.340043340356448 1635 4562705 SGTC_919 tnp00227 403.569 nM 0.412070830899604 0.351665860406328 no 1158 0.340143753864984 1626 1269246 A methoxyflavone. YNL221C POP1 SGTC_2967 9089538 49.85 µM 0.41114524259545 0.352005956207647 no 1159 0.340483018483687 1782 728216 SGTC_3051 9093778 49.47 µM 0.411084748742093 0.352028188040305 no 1160 0.340505196365097 1626 17217378 SGTC_109 0132-0036 33.701 µM 0.409504215612763 0.35260922193725 no 1161 0.341084836869809 1597 67274 A color developer. SGTC_2313 7726885 200 µM 0.407334120350447 0.353407550304753 no 1162 0.341881302948252 1617 726423 SGTC_1690 st023502 41.2 µM 0.406656946497626 0.35365679934499 no 1163 0.342129982917946 1705 24207482 SGTC_1117 retinoic acid 1.10837 µM 0.403936398570265 0.354658789618291 no 1164 0.343129744762892 1734 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3191 9110352 49.47 µM 0.402038426406329 0.355358417945093 no 1165 0.343827873293322 1647 17122424 SGTC_1983 st071813 46.9 µM 0.400615505348538 0.355883253537603 no 1166 0.344351614064228 1630 11838595 SGTC_171 k064-0041 9.68 µM 0.398737066059444 0.356576522559305 no 1167 0.345043476623589 1560 53325 SGTC_607 4491-0986 66.8 µM 0.398287632979602 0.356742463630827 no 1168 0.345209087741908 1734 698981 YDR232W HEM1 SGTC_1111 tnp00062 510.699 nM 0.397179739045556 0.357151639404526 no 1169 0.345617460964115 1747 676306 SGTC_448 monastrol 171 µM 0.39655921094218 0.357380889372139 no 1170 0.345846268148274 1654 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_904 1141-0088 396 µM 0.393613097993066 0.358470012315478 no 1171 0.346933354759383 1555 1378119 SGTC_1897 st060201 15 µM 0.392802401272249 0.358769914288348 no 1172 0.347232715490133 1592 611878 SGTC_797 k781-0471 270 µM 0.390380033390342 0.359666541895162 no 1173 0.348127775014211 1701 23738129 SGTC_2191 5911152 200 µM 0.389986352231042 0.359812334200052 no 1174 0.348273319435457 1639 2875902 SGTC_231 b-estradiol 524 µM 0.389677501263655 0.359926725543583 no 1175 0.348387517671652 1594 450 A steroid. SGTC_1527 coumarin 137 µM 0.388393495483264 0.360402426358216 no 1176 0.348862428513527 1704 323 A hepatotoxic, DNA x-linker. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.387366535151998 0.360783052135213 no 1177 0.349242437370271 1717 140250 A respiratory chain inhibitor. SGTC_1272 0839-0021 27 µM 0.387326942324585 0.360797729322518 no 1178 0.349257091038492 1669 5027250 SGTC_759 3486-0358 89.3 µM 0.386744040044202 0.36101383677366 no 1179 0.349472854511692 1812 875103 SGTC_1899 st063254 59.6 µM 0.386527259467089 0.36109421816897 no 1180 0.349553109071376 1582 3093813 SGTC_2904 7225135 42.03 µM 0.38574435259195 0.361384568053625 no 1181 0.349843005805466 1696 4446116 SGTC_1024 4507-0395 26 µM 0.384544776785301 0.361829599198357 no 1182 0.350287357576878 1672 4201836 SGTC_2177 5811945 192 µM 0.384020781616664 0.362024055084806 no 1183 0.35048152237901 1720 5343475 SGTC_3240 9133527 49.47 µM 0.383355682607158 0.362270926247545 no 1184 0.350728029045424 1633 17617455 SGTC_1483 3453-0561 55.9 µM 0.38316997491196 0.362339867386158 no 1185 0.350796869403575 1693 4546991 SGTC_1548 st061468 90.8 µM 0.38238909979424 0.36262980415362 no 1186 0.351086387149762 1726 390799 SGTC_2814 7977482 42.97 µM 0.381586228854636 0.362927990059901 no 1187 0.351384150229021 1767 6456762 SGTC_1470 k295-0292 231 µM 0.381133392153251 0.363096210083477 no 1188 0.351552135345797 1732 5045612 SGTC_875 0709-0210 25.7 µM 0.380226968306515 0.363433008231195 no 1189 0.351888471041773 1719 6251364 SGTC_2540 epiandrosterone 100 µM 0.378769341951552 0.363974836967274 no 1190 0.352429577788739 1671 441302 A steroid. SGTC_2648 atorvastatin 78.68 µM 0.37793555660799 0.364284893974897 no 1191 0.352739233831327 1743 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1795 st049545 62.3 µM 0.377764462582998 0.364348529137752 no 1192 0.352802787797758 1779 5291882 SGTC_2272 7805186 180 µM 0.377118614879494 0.364588773571215 no 1193 0.353042729051477 1746 2956062 YPR165W RHO1 SGTC_792 4534-1957 155 µM 0.375983890773261 0.365011000548388 no 1194 0.353464436076702 1699 1717904 SGTC_3048 9093155 49.47 µM 0.375473155979192 0.365201096689384 no 1195 0.353654303481168 1727 25236002 SGTC_37 0566-0070 1.56 µM 0.374088467885007 0.365716645901387 no 1196 0.35416924907917 1769 1626686 SGTC_3023 9089636 49.47 µM 0.37271184519421 0.366229432729092 no 1197 0.354681459753361 1739 17249241 SGTC_1259 0671-0132 43 µM 0.372334173326706 0.366370155907088 no 1198 0.354822029039739 1657 X1259 SGTC_1046 2001-0062 216 µM 0.369302203607492 0.367500538782905 no 1199 0.35595124161373 1641 739778 SGTC_2415 st077333 57.7 µM 0.369056775739713 0.367592089916109 no 1200 0.356042703084882 1895 2766255 SGTC_2224 6650123 117.647 µM 0.36842631234909 0.367827304040211 no 1201 0.35627769036347 1684 2908370 SGTC_1848 st056003 16.4 µM 0.366706023670192 0.368469363596223 no 1202 0.356919156444703 1726 146492 SGTC_215 1287-0124 461.5 µM 0.366663156648983 0.368485367459432 no 1203 0.356935145996021 1787 5560863 SGTC_1302 1159-0335 255 µM 0.366660587509962 0.368486326622419 no 1204 0.356936104301993 1645 649284 SGTC_1001 4048-4355 44.4 µM 0.366461265540068 0.368560744032755 no 1205 0.357010455476172 1630 21824233 SGTC_3115 9123671 49.47 µM 0.366255950329939 0.368637404190476 no 1206 0.35708704793009 1730 3286988 SGTC_2017 5132927 60.65 µM 0.366214239601725 0.368652978692748 no 1207 0.357102608743007 1608 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2309 7664088 163.95 µM 0.365081066147196 0.369076180425529 no 1208 0.357525446968339 1827 704922 SGTC_1529 apigenin 74 µM 0.364079045880937 0.36945053318458 no 1209 0.357899491788092 1785 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_115 0527-0192 112.043 µM 0.363383261244547 0.369710549783003 no 1210 0.358159302011682 1676 4233931 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.36248079205948 0.370047893708783 no 1211 0.358496387359194 1634 6708760 SGTC_1065 prochlorperazine maleate 2.48 µM 0.361810844485357 0.37029838550397 no 1212 0.358746693846305 1693 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_468 gf-109203x 121 µM 0.361120929104419 0.370556400712626 no 1213 0.35900452414452 1778 2396 A protein kinase C inhibitor. SGTC_3294 9122953 26.2835 µM 0.358118011826635 0.371680111551393 no 1214 0.360127500139785 1635 16459826 SGTC_619 1652-1634 108 µM 0.357889048014391 0.371765836290262 no 1215 0.360213173520486 1674 5400454 SGTC_1139 k015-0024 46.9 µM 0.356913979736043 0.372130975933183 no 1216 0.360578101861676 1800 2766652 SGTC_749 1000-0129 128 µM 0.356403600240424 0.37232214666812 no 1217 0.360769166782357 1822 708470 SGTC_2104 5389443 200 µM 0.355595653176483 0.372624840374911 no 1218 0.361071699708223 1763 2244536 SGTC_825 1988-2224 89.6 µM 0.355321329718378 0.372727632317857 no 1219 0.361174438935993 1691 1180859 SGTC_1086 cerivastatin 2.18 µM 0.354970801041154 0.372858992364021 no 1220 0.361305733006397 1742 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2136 5328288 199.296 µM 0.354657660891973 0.372976353625129 no 1221 0.361423036641533 1662 262395 SGTC_3346 9158254 43.5805 µM 0.353056687475829 0.373576563718959 no 1222 0.362022971471046 1685 17639500 SGTC_1265 0819-1001 68.8 µM 0.352354380945452 0.373839957597877 no 1223 0.36228625481707 1672 3106768 SGTC_2465 5809242 33.21 µM 0.352220511075712 0.373890171003832 no 1224 0.362336447861031 1752 2731748 SGTC_315 k915-0449 187 µM 0.351248826726104 0.374254705321213 no 1225 0.362700841169543 1748 20970215 YNL149C PGA2 SGTC_385 1494-0393 12.4 µM 0.351206784608627 0.37427048026191 no 1226 0.362716610278452 1734 3090647 SGTC_2140 5586273 200 µM 0.347492947694995 0.375664804869707 no 1227 0.364110507873585 1706 854421 SGTC_1943 st076331 65.2 µM 0.347346152872907 0.375719951094121 no 1228 0.364165640801348 1771 24208415 SGTC_3243 9134147 49.47 µM 0.346758324721837 0.375940805177392 no 1229 0.364386444368754 1763 24282180 SGTC_1235 benzylparaben 21.5 µM 0.345900160306778 0.376263300796289 no 1230 0.364708874083835 1726 7180 SGTC_2883 9059145 45.46 µM 0.345802359995715 0.376300059349607 no 1231 0.364745625717459 1675 16476510 SGTC_2126 5251174 33.877 µM 0.345726851295888 0.37632844029857 no 1232 0.364774001406657 1891 790722 SGTC_1215 3852-0577 11.2 µM 0.343924367608776 0.377006125939073 no 1233 0.365451582889923 1815 2884876 SGTC_398 bronopol 33.3 µM 0.34369917912201 0.377090817463971 no 1234 0.365536264288965 1742 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_640 3381-0960 37.1 µM 0.342828640209163 0.377418275519425 no 1235 0.365863689230622 1787 1745025 SGTC_947 3447-0010 211 µM 0.342706396898424 0.377464265084108 no 1236 0.365909674912722 1693 748350 SGTC_1555 citronellol 128 µM 0.341756150856245 0.377821819528604 no 1237 0.366267205620382 1838 8842 A terpine precursor. SGTC_2188 6126565 140.678 µM 0.341634687963406 0.377867530610636 no 1238 0.366312914491427 1785 874518 SGTC_2773 thioridazine 9.09 µM 0.341609830670259 0.377876885561331 no 1239 0.366322269012644 1737 5452 An antipsychotic. SGTC_2269 7935389 174.42 µM 0.341344470527126 0.377976757335802 no 1240 0.366422136689274 1648 97605 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.339466466212201 0.378683801668111 no 1241 0.367129177475094 1677 16623 A steroid. SGTC_1507 4075-3230 155 µM 0.339249713278941 0.378765432537863 no 1242 0.367210810806936 1811 659771 SGTC_3057 9095946 49.47 µM 0.338699191068029 0.378972787865017 no 1243 0.367418175058893 1729 24540043 SGTC_2650 prasterone 100 µM 0.338608140900574 0.379007085457159 no 1244 0.367452474496546 1751 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2161 5662504 8.5105 µM 0.337785612314638 0.379316966031511 no 1245 0.367762376495512 1691 2859334 SGTC_2090 5301565 104.445 µM 0.337719205671333 0.379341987549545 no 1246 0.367787400116617 1728 2056344 SGTC_266 formosanin C 406 nM 0.337664933538737 0.379362437251583 no 1247 0.367807851578857 1751 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1657 st012939 43.4 µM 0.336792069053958 0.379691378317504 no 1248 0.368136826072901 1811 24207257 SGTC_2512 diallyl trisulfide 49.23 µM 0.335752903887742 0.380083103728156 no 1249 0.368528603848201 1733 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_884 0851-0618 334 µM 0.335077418160502 0.380337801954673 no 1250 0.368783343439506 1833 9642473 SGTC_1569 carminic acid 40.6 µM 0.334313166722149 0.38062603268768 no 1251 0.369071627933408 1857 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2759 disulfiram 3.38 µM 0.333799910664855 0.38081963992216 no 1252 0.369265275420473 1688 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3026 9090633 49.47 µM 0.333061201043258 0.381098343717604 no 1253 0.369544043000539 1686 25236842 SGTC_2849 9019321 12.99 µM 0.332171647217303 0.381434040575301 no 1254 0.369879825830819 1753 16489627 SGTC_3169 9102970 49.47 µM 0.331923372607134 0.381527749556074 no 1255 0.369973560593733 1763 17027839 SGTC_139 0099-0334 718.624 µM 0.331690460578439 0.381615666384665 no 1256 0.370061502318174 1809 97690 SGTC_839 0122-0028 230 µM 0.331602991662447 0.381648684675845 no 1257 0.370094530136155 1752 759448 SGTC_2952 9073731 13.78 µM 0.329962929906946 0.382267944236069 no 1258 0.370713986251242 1675 16457353 SGTC_3185 9108267 49.47 µM 0.329050311870385 0.382612663923389 no 1259 0.371058830051448 1675 4910486 SGTC_3014 9081533 49.47 µM 0.328891794616027 0.382672549524014 no 1260 0.37111873828416 1854 21367265 SGTC_2268 7933382 153.85 µM 0.328752993006823 0.382724989133555 no 1261 0.371171197972024 1722 935025 YOR257W CDC31 SGTC_1905 st060207 84.5 µM 0.327909412140792 0.383043742391912 no 1262 0.371490078501876 1735 1948547 SGTC_2308 7584454 197.62 µM 0.327536803428492 0.383184560578752 no 1263 0.371630955771662 1833 893577 SGTC_2246 7293507 91.5585 µM 0.327325816050735 0.383264304852277 no 1264 0.37171073427963 1887 887656 SGTC_2939 9044578 71.43 µM 0.326382126426408 0.383621039971027 no 1265 0.372067629414471 1697 2653634 SGTC_2220 6782180 200 µM 0.325666674559648 0.38389156205012 no 1266 0.372338280319579 1838 833803 SGTC_3234 9132280 49.47 µM 0.325141788784859 0.384090064493887 no 1267 0.372536881395004 1750 17612295 SGTC_2195 6536160 144.242 µM 0.322389537460795 0.385131413533755 no 1268 0.373578804684404 1702 3834386 SGTC_2725 haloperidol 53.21 µM 0.32205401346557 0.385258420109822 no 1269 0.373705887822244 1735 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_119 0121-0043 24.815 µM 0.321932394307252 0.385304459895602 no 1270 0.373751955711582 1770 1092378 SGTC_339 3091-4833 71.4 µM 0.321477530986563 0.385476665921665 no 1271 0.373924268505981 1782 3240077 SGTC_300 r073-0011 5.04 µM 0.320775881727073 0.385742346537151 no 1272 0.374190118951677 1793 2735780 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.32040503982321 0.38588278808098 no 1273 0.374330652772377 1743 4620898 SGTC_328 k915-0120 63.5 µM 0.320274081604086 0.385932386845273 no 1274 0.374380284538929 1855 6624543 SGTC_1303 1160-0052 261 µM 0.318783194404702 0.386497172724715 no 1275 0.374945461431279 1790 3562476 SGTC_898 1000-0849 28.3 µM 0.316099372990689 0.387514477836213 no 1276 0.375963541321082 1857 6751807 SGTC_3145 9085516 49.47 µM 0.31490266767422 0.387968339694509 no 1277 0.376417778034032 1695 25236195 SGTC_928 2764-0428 58.7 µM 0.31426571479853 0.388209972584976 no 1278 0.376659617832999 1804 662578 SGTC_1759 st043059 70 µM 0.311755770833185 0.389162559268749 no 1279 0.377613069825229 1684 669426 SGTC_255 tunicamycin 200.472 nM 0.311455509980859 0.389276560544028 no 1280 0.377727179954743 1889 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_133 0724-0033 378.92 µM 0.308388200392881 0.390441682975411 no 1281 0.378893479734574 1793 280309 SGTC_353 1988-1175 58.3 µM 0.304880417135059 0.391775326426969 no 1282 0.380228615508697 1716 2788357 SGTC_1664 st014217 9.02 µM 0.301975723248673 0.392880642150076 no 1283 0.381335284794264 1847 3982782 SGTC_2441 5730946 39.09 µM 0.301794650335532 0.392949574072281 no 1284 0.381404304628621 1857 1774275 SGTC_1147 3809-1045 12.3 µM 0.301428550566253 0.393088953380732 no 1285 0.381543862947847 1764 325925 SGTC_981 1488-1094 54.9 µM 0.300497965079869 0.393443301966499 no 1286 0.381898674190068 1759 3449522 SGTC_157 1348-1695 65.819 µM 0.300497069153845 0.393443643160028 no 1287 0.381899015834299 1763 5380510 SGTC_1591 genipin 88.4 µM 0.299242447116142 0.393921518274913 no 1288 0.382377532056356 1843 442424 A DNA cross-linking agent. SGTC_2629 bisabolol 100 µM 0.29892595660673 0.39404209214544 no 1289 0.382498270796416 1822 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1524 corynanthine 62.1 µM 0.297515679215554 0.394579490976535 no 1290 0.383036419680737 1823 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1479 0549-0158 134 µM 0.297265010063381 0.39467503173663 no 1291 0.383132096390978 1773 5440202 SGTC_376 3970-0862 59.1 µM 0.296624723383682 0.394919101184352 no 1292 0.383376516703924 1893 3135186 SGTC_2146 5545642 200 µM 0.296081119374936 0.395126348755898 no 1293 0.383584066228791 1838 825326 SGTC_736 0958-0254 92.6 µM 0.295681590911622 0.395278686832838 no 1294 0.383736628611993 1829 6812352 SGTC_1868 st057644 42.7 µM 0.295224074484519 0.395453155069437 no 1295 0.383911356189486 1764 688665 SGTC_587 k089-0003 57 µM 0.290287651944898 0.397336924741871 no 1296 0.385798092331653 1907 9659696 SGTC_1840 st055363 71 µM 0.289970769296766 0.39745793148362 no 1297 0.38591930001841 1725 676033 SGTC_1159 4092-0538 61.2 µM 0.289850525182293 0.397503851218526 no 1298 0.385965296335878 1822 717301 SGTC_1616 st002734 56.1 µM 0.289777856840406 0.397531603045012 no 1299 0.385993094532845 1837 4026101 SGTC_258 haloperidol 50.781 µM 0.288533599347199 0.398006861686109 no 1300 0.386469157500335 1754 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1042 0350-0096 82 µM 0.287196556727233 0.398517729405001 no 1301 0.38698091132633 1746 3122515 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.286278404564171 0.398868644976518 no 1302 0.387332448469103 1873 688761 SGTC_849 0386-0493 241 µM 0.284089609189214 0.399705526652125 no 1303 0.388170854862206 1811 726119 SGTC_280 3448-3607 3.04 µM 0.283698159527646 0.399855245374287 no 1304 0.388320852646248 1918 626179 SGTC_183 3914-0051 30.55 µM 0.283607145970682 0.399890057665391 no 1305 0.388355730097547 1956 1596232 SGTC_2450 5739737 12.93 µM 0.283308001434092 0.400004484758315 no 1306 0.388470372096698 1810 2262825 SGTC_3090 9117696 49.47 µM 0.281836249988548 0.400567575740338 no 1307 0.389034536842165 1924 7923821 SGTC_2947 9072639 7.68 µM 0.281692943554254 0.400622415735001 no 1308 0.389089482851613 1745 16488146 SGTC_2370 9071495 200 µM 0.280608246351581 0.401037567240983 no 1309 0.389505445198667 1776 21791103 SGTC_1464 k208-0027 110 µM 0.278298307439383 0.401922033458512 no 1310 0.390391687643623 1924 X1464 SGTC_101 0490-5701 117.494 µM 0.2782264805183 0.401949543773769 no 1311 0.390419254269616 1910 4661669 SGTC_1472 k841-0093 193 µM 0.27812642132727 0.40198786809574 no 1312 0.390457657144312 1903 X1472 SGTC_1309 pyrazolanthrone 13.4 µM 0.277492329786546 0.402230757518434 no 1313 0.390701047305363 1908 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_462 ag-879 158 µM 0.276780078048789 0.402503631305997 no 1314 0.390974489603182 1924 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_11 0438-0307 1.3 µM 0.276380527274028 0.402656725709681 no 1315 0.391127905725251 1951 4011476 SGTC_3327 9140648 26.9345 µM 0.275472603950631 0.403004666825461 no 1316 0.39147658538827 1927 8029710 SGTC_2745 rifampicin 24.3 µM 0.275114398849241 0.403141961991234 no 1317 0.391614174795083 1956 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2514 salinomycin 42.74 µM 0.274774683612655 0.403272181275178 no 1318 0.391744674627056 1965 23682228 A polyether potassium ionophore. SGTC_2518 prenyletin 46.28 µM 0.274593622713451 0.403341589729845 no 1319 0.391814233202371 1935 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1685 st024049 53.0905 µM 0.274446661981101 0.40339792835814 no 1320 0.391870693982264 1849 1941139 SGTC_480 am 92016 50 µM 0.273890045645281 0.403611330062823 no 1321 0.39208456080758 1790 2129 K+ channel blocker. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.26881477341923 0.405558460135502 no 1322 0.39403611206231 1963 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2673 kobusone 100 µM 0.26769766314694 0.40598735570737 no 1323 0.394466024362676 1880 6710676 An epoxy ketone and protein crosslinker. SGTC_1674 st016616 23.6 µM 0.267665737332029 0.405999614744572 no 1324 0.394478312687961 1726 625830 SGTC_1006 4099-6547 255 µM 0.267598121617445 0.406025578475738 no 1325 0.394504338490781 1894 3146833 SGTC_1556 plumbagin 1.48 µM 0.266785287144143 0.406337730777511 no 1326 0.394817241487143 1914 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_104 0074-0074 590.992 µM 0.266771318379187 0.406343095714302 no 1327 0.394822619397547 1917 3943124 SGTC_114 0364-0001 490.298 µM 0.266308135634829 0.406520998711973 no 1328 0.395000953972027 1778 4003655 SGTC_2985 9022375 71.43 µM 0.265538846133152 0.406816516306987 no 1329 0.395297194333308 1853 4939335 SGTC_1881 5652484 16 µM 0.265078141272766 0.406993518521961 no 1330 0.395474632959651 1946 2255129 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.261742882948761 0.408275484934769 no 1331 0.396759838451442 1855 65057 A dermal irritant. YDR527W RBA50 SGTC_1316 1272-0050 65.9 µM 0.261065642849256 0.408535914756331 no 1332 0.397020943083695 1850 7340392 SGTC_2653 dihydrofissinolide 100 µM 0.260247464851202 0.408850595524643 no 1333 0.397336446792024 1879 6857746 SGTC_431 k089-0097 107 µM 0.258051712697042 0.409695397262811 no 1334 0.398183498684155 1859 5499420 SGTC_3022 9087993 49.47 µM 0.257422187930356 0.409937680466962 no 1335 0.398426438193529 1895 17173644 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.256780897504072 0.410184527242674 no 1336 0.398673958663761 1861 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2770 toltrazuril 17.5 µM 0.2558499734154 0.410542923689685 no 1337 0.399033342273347 1962 68591 Kills coccidiodes. SGTC_1966 st070145 16.1 µM 0.255031061552672 0.410858258332384 no 1338 0.399349554304752 1819 3748532 SGTC_1375 2910-0797 186 µM 0.254726806686382 0.410975431052448 no 1339 0.399467055153128 1874 742508 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.254649815538915 0.411005082658612 no 1340 0.399496789975991 1936 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2433 5607874 27.82 µM 0.25380289179264 0.41133129198841 no 1341 0.399823919628111 1801 2252428 SGTC_465 cgp-37157 41 µM 0.252835865759818 0.411703836034509 no 1342 0.400197525525978 1967 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_600 1495-0418 41.6 µM 0.25139479392316 0.412259152505353 no 1343 0.400754446171817 1868 5377768 SGTC_1320 1313-0481 95.3 µM 0.251183057247075 0.412340759982882 no 1344 0.400836291548066 1985 6813365 YLR208W SEC13 SGTC_2287 7945887 168.79 µM 0.250274939204102 0.412690809473992 no 1345 0.401187367747653 1993 1245853 SGTC_3171 9103192 49.47 µM 0.249951516783805 0.41281549491292 no 1346 0.401312421344586 2008 13018434 SGTC_2378 9074213 121.43 µM 0.249672772515508 0.412922963140493 no 1347 0.401420207925602 1848 657714 SGTC_31 0508-1974 57.237 µM 0.2491773763246 0.41311397635548 no 1348 0.401611789338601 1944 6810525 SGTC_1179 1021-1431 9.29 µM 0.24862284074967 0.413327816736022 no 1349 0.401826269400873 1890 2840958 SGTC_872 0588-0139 234 µM 0.248231929677645 0.413478575581822 no 1350 0.401977481499028 1844 2047100 SGTC_2342 7990637 118.86 µM 0.247619924293542 0.413714627317292 no 1351 0.402214246691165 1879 2033102 YER133W GLC7 SGTC_1137 ixabepilone 100 µM 0.247239364226927 0.413861425847594 no 1352 0.402361491235851 1783 154225 A novel microtubule stabilizer. SGTC_2566 crystal violet carbinol 226 nM 0.246103463811704 0.41429966343671 no 1353 0.402801070897485 1725 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1051 3253-3903 78 µM 0.246059866235149 0.414316485788462 no 1354 0.40281794508248 1877 5509239 SGTC_488 nitrendipine 139 µM 0.243925506429821 0.415140231248284 no 1355 0.403644257229343 1942 4507 Dihydropyridine L-type calcium channel blocker. SGTC_348 k064-0012 10.7 µM 0.243226754228484 0.415409992418104 no 1356 0.403914871095552 1830 5066323 SGTC_665 3914-0008 307 µM 0.243111524292995 0.415454482068172 no 1357 0.403959501949942 1842 1069549 SGTC_16 erodoxin 22.806 µM 0.241535335369494 0.416063148601687 no 1358 0.404570116668807 1930 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_209 4077-0173 175.592 µM 0.24150055948856 0.416076580051293 no 1359 0.404583591452675 1909 15993494 SGTC_1468 k284-1086 134 µM 0.240903279085875 0.416307282279257 no 1360 0.404815040316663 1874 15996457 SGTC_3350 9150499 3.57 µM 0.23917411469128 0.416975342077901 no 1361 0.40548528686232 1890 4910996 YPR165W RHO1 SGTC_1098 clofazimine 15.1 µM 0.23857554513273 0.417206654407228 no 1362 0.405717364880466 1962 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2569 tetrandrine 100 µM 0.237700071779172 0.417545025544147 no 1363 0.406056863996865 1800 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1563 conessine 56.1 µM 0.237086106685881 0.417782359977372 no 1364 0.406294995198173 2015 441082 An anti-amoebic, histamine inhibitor. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.236834760837788 0.417879528908687 no 1365 0.406392491672081 2018 5024745 SGTC_2335 9018011 154.17 µM 0.236414017551215 0.418042197181667 no 1366 0.406555710007587 1989 6458208 SGTC_1821 st053465 65.6 µM 0.235550861685352 0.418375955394777 no 1367 0.406890603606335 1861 675086 SGTC_2417 cerulenin 830 nM 0.235408291272808 0.41843108904511 no 1368 0.406945925688869 1925 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2762 leflunomide 42.06 µM 0.235140278185238 0.418534737185965 no 1369 0.407049928744832 1869 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1016 4226-1401 38 µM 0.234925914433712 0.418617641702898 no 1370 0.407133117778506 1986 2901613 SGTC_2381 9035592 200 µM 0.234668892395273 0.418717048945367 no 1371 0.407232866913877 1817 4749657 SGTC_1812 st052057 4.327 µM 0.233314202325562 0.419241081882484 no 1372 0.407758715519189 1860 3645418 SGTC_112 phenothiazine 287.218 µM 0.229159343212313 0.42084919025399 no 1373 0.409372535590093 2026 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3297 9117502 71.43 µM 0.2281273516878 0.421248821103568 no 1374 0.40977361854175 2011 7453720 SGTC_1190 1486-1332 13 µM 0.228037130909615 0.421283762274985 no 1375 0.409808687293465 1958 4150046 SGTC_469 w7 172 µM 0.225899531683405 0.422111803553332 no 1376 0.410639781036388 1958 45115570 A P450 inhibitor. SGTC_3347 9188721 44.724 µM 0.224896538905066 0.422500451555824 no 1377 0.411029880943237 1951 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.223791602313911 0.422928688940295 no 1378 0.411459732321163 1877 2724 A muscle relaxant with antifungal properties. SGTC_1167 k781-0610 148 µM 0.22306350476228 0.423210925622621 no 1379 0.411743040860477 1897 4525169 SGTC_1502 4534-4282 27.7 µM 0.222989358669433 0.423239669516654 no 1380 0.411771894278066 1905 3278949 SGTC_2665 lovastatin 100 µM 0.221425743367369 0.423845924398058 no 1381 0.412380474775749 1917 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1328 1441-0025 69.2 µM 0.221222075011131 0.423924905291591 no 1382 0.412459760833367 1834 4562601 SGTC_705 1124-0212 310 µM 0.219047858549065 0.424768238155765 no 1383 0.41330638359094 2039 9554485 SGTC_2635 hydroquinidine 100 µM 0.218762579265111 0.424878917639833 no 1384 0.413417499108652 1900 442912 An experimental heart treatment. SGTC_1366 1683-0113 21.9 µM 0.218740830739968 0.424887355633817 no 1385 0.413425970385598 1886 708623 SGTC_2945 9067681 61.76 µM 0.218173359696189 0.425107535233748 no 1386 0.413647020497536 1989 16456930 SGTC_1727 st034309 9.9045 µM 0.217170452411767 0.425496721826525 no 1387 0.41403775536551 2040 870305 SGTC_789 1309-1135 70.6 µM 0.215187615504564 0.426266391656206 no 1388 0.41481052307862 1955 3092424 SGTC_365 0121-0052 13.6 µM 0.213931540730188 0.426754102684477 no 1389 0.415300221814259 1963 3101739 SGTC_2630 antimycin a 100 µM 0.213165827839193 0.427051470096828 no 1390 0.415598810563713 1917 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_964 1287-0107 19.4 µM 0.210188591634232 0.428208083193301 no 1391 0.416760241621902 2020 51516812 YPR165W RHO1 SGTC_695 3505-6186 243 µM 0.208513605631499 0.428859062830928 no 1392 0.41741398017225 1973 1819379 SGTC_2163 5671233 125 µM 0.208267155540576 0.428954861496814 no 1393 0.41751018770822 2024 701023 SGTC_188 3229-0966 278.469 µM 0.208074529236904 0.429029741003133 no 1394 0.417585387313128 2042 5722370 SGTC_721 1187-1332 279 µM 0.207916639673581 0.429091119222355 no 1395 0.417647028249822 1933 25730 SGTC_642 0335-0876 158 µM 0.20777151484711 0.429147536771452 no 1396 0.417703687549261 1936 6812350 SGTC_2344 7990960 76.95 µM 0.207284307510325 0.429336950119316 no 1397 0.417893914400858 1914 140813 SGTC_524 r073-0010 27.8 µM 0.207229667204964 0.429358193842757 no 1398 0.417915249542192 1869 2772106 SGTC_541 4513-1321 94 µM 0.205544182113936 0.430013597462149 no 1399 0.418573491289738 1878 747515 SGTC_1682 st012968 530 nM 0.205055825259342 0.430203531940881 no 1400 0.418764254669295 1864 24207270 SGTC_730 1436-0052 41.2 µM 0.204072705385864 0.430585941360414 no 1401 0.419148341718742 2012 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_817 1391-0715 46 µM 0.202368529682682 0.431248977776323 no 1402 0.419814314536386 1893 1353946 SGTC_2200 6600604 21.907 µM 0.202170873422779 0.431325891636277 no 1403 0.419891571295614 1962 2904777 SGTC_3218 9131285 49.47 µM 0.200932109593308 0.431807990238982 no 1404 0.420375829940007 2047 17156417 SGTC_129 0088-0017 176.636 µM 0.200102711033056 0.432130830042523 no 1405 0.42070012657443 2057 182446 SGTC_2253 7938677 135.83 µM 0.198092064706215 0.432913653141432 no 1406 0.421486516631466 2081 2301972 SGTC_1174 0739-0097 51.1 µM 0.197497811481673 0.433145069674296 no 1407 0.421718996949158 1944 728447 SGTC_2760 etidronate 98.04 µM 0.196726204395066 0.433445586277438 no 1408 0.422020901326646 1945 3305 A chelator and antioxidant. SGTC_2940 9060638 45.86 µM 0.19596844375449 0.433740747582147 no 1409 0.422317432652841 1945 4027022 SGTC_2001 4023502 57.655 µM 0.195883188907359 0.433773958183617 no 1410 0.422350797837343 1983 108941 YCR052W RSC6 SGTC_2657 nystatin 74.44 µM 0.195811196064575 0.433802003001397 no 1411 0.42237897326148 2021 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2438 5259590 200 µM 0.195507960111822 0.433920132247917 no 1412 0.422497653327568 2044 1201127 SGTC_94 0334-0113 514.748 µM 0.194931722938277 0.434144628689676 no 1413 0.422723199613229 1870 6795178 SGTC_106 0092-0003 11.579 µM 0.193838501985919 0.434570595340848 no 1414 0.423151169250819 2068 1072148 SGTC_501 nsc-95397 161 µM 0.193032054370619 0.434884871287141 no 1415 0.423466932202639 2046 262093 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.192314878349027 0.435164392298299 no 1416 0.423747782343814 1922 279621 SGTC_23 0213-0011 39.996 µM 0.192232421248158 0.43519653222337 no 1417 0.423780075491344 2077 627608 SGTC_2597 laccaic acid a 100 µM 0.191750320882916 0.435384452675132 no 1418 0.423968893462088 1952 5491415 A textile dye. SGTC_440 fluspirilene 35.1 µM 0.190901428196845 0.435715382491986 no 1419 0.42430141060642 2022 3396 An atypical antipsychotic. SGTC_1108 betulinic acid 729.144 nM 0.190365341695859 0.435924392076306 no 1420 0.424511427178447 1940 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1920 st075728 45.7 µM 0.189964222889898 0.436080792118947 no 1421 0.424668582998215 2100 3400306 SGTC_2059 5238311 157 µM 0.189359889614052 0.436316446285302 no 1422 0.424905379571338 1929 703021 SGTC_2321 7390090 138.78 µM 0.189083881130763 0.436424080763361 no 1423 0.425013537299167 1904 649046 SGTC_1815 st051655 58.2 µM 0.187160717351665 0.437174183355782 no 1424 0.425767311782017 2096 5984156 SGTC_3318 9139014 38.6185 µM 0.186880084280141 0.437283659231945 no 1425 0.425877327271485 1948 16643984 SGTC_534 k292-0788 63.4 µM 0.186493705756678 0.437434394609171 no 1426 0.426028807177426 2122 4146317 SGTC_1752 st044819 83.042 µM 0.186290597066223 0.437513635743939 no 1427 0.426108440426279 1938 441209 YML126C ERG13 SGTC_1788 fluconazole 20 µM 0.18535166482111 0.43787998472909 no 1428 0.426476608665375 1935 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2736 butenafine 14.65 µM 0.184509011670781 0.438208813256508 no 1429 0.426807079116836 2065 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1411 3909-8223 150 µM 0.184401277072579 0.438250857608288 no 1430 0.426849334019854 2079 X1411 SGTC_1968 st069590 43.6 µM 0.182536370065959 0.438978763629953 no 1431 0.427580907297969 2074 6384066 SGTC_2932 9016711 44.54 µM 0.181982462443751 0.439195003392253 no 1432 0.427798244512845 2108 7117328 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.1809815913173 0.439585779024344 no 1433 0.428191012702491 2066 94937 An inhibitor of serotonin biosynthesis. SGTC_2523 spermine 47.74 µM 0.1805341880173 0.439760480224905 no 1434 0.428366608575091 2091 1103 A DNA binding polyamine. SGTC_2998 9066762 71.4286 µM 0.180339685780551 0.439836432753558 no 1435 0.428442950814698 2050 4945196 SGTC_492 tmb-8 126 µM 0.17995925226629 0.439984997276168 no 1436 0.4285922789261 2090 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_83 0170-0301 39.027 µM 0.179682755810485 0.440092978251236 no 1437 0.42870081598483 2106 3089716 SGTC_2731 amoxapine 43.43 µM 0.179651040956568 0.440105364231544 no 1438 0.428713265809231 2127 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2531 methyl deoxycholate 70.07 µM 0.178255937772777 0.440650268353799 no 1439 0.429260990554451 1960 16667744 Haematoxylin. SGTC_833 3852-0053 558 µM 0.177614214898978 0.440900952450101 no 1440 0.429512980088282 2036 3123681 SGTC_2775 cyproheptadine 69.59 µM 0.17738261834765 0.440991429679772 no 1441 0.429603929685435 2114 2913 A selective serotonin reuptake inhibitor. SGTC_816 0325-0417 81.3 µM 0.177197280661456 0.441063837296404 no 1442 0.429676715792085 1959 68101 SGTC_555 4296-0685 37 µM 0.176668360423143 0.441270486365441 no 1443 0.429884447314071 2058 2908540 YHR072W ERG7 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.175912584360658 0.441565795710438 no 1444 0.430181309317842 1954 75037 A free radical scavenger. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.175550000621277 0.441707481977683 no 1445 0.430323742952669 1938 6708561 SGTC_2162 5663267 200 µM 0.175322605348064 0.441796344671586 no 1446 0.430413075180022 2087 6456493 SGTC_160 3453-0671 289.699 µM 0.17270887273871 0.442817961782506 no 1447 0.431440134582718 2021 5322268 SGTC_228 caffeine 993.056 µM 0.172645331339999 0.442842802666423 no 1448 0.431465108810827 2108 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1743 st037606 46.3785 µM 0.172203452971768 0.443015556870667 no 1449 0.431638791677793 2003 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1038 k292-0204 154 µM 0.171670871699464 0.443223786150615 no 1450 0.431848143410998 1957 4454212 SGTC_1508 1080-0625 72.9 µM 0.171453131746591 0.443308922903972 no 1451 0.43193374006372 2107 767111 SGTC_846 0335-0850 148 µM 0.170325518282984 0.443749863789259 no 1452 0.432377071890316 2094 6819598 SGTC_2902 5787006 60.46 µM 0.169539700915197 0.444057190272024 no 1453 0.432686073752953 1985 591003 SGTC_951 1171-0579 82.7 µM 0.169083467787935 0.444235634612484 no 1454 0.432865494246145 2059 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_342 k048-0088 23.3 µM 0.168919944111455 0.444299595621212 no 1455 0.432929805746347 1980 6820570 SGTC_2772 vinpocetine 57.06 µM 0.168902897404143 0.444306263391142 no 1456 0.432936510072405 2088 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1333 1482-0047 286 µM 0.168636908704075 0.444410306137356 no 1457 0.433041123681661 2133 3811116 SGTC_2856 9022925 19.48 µM 0.168624197136856 0.444415278423347 no 1458 0.433046123270709 2017 4944862 SGTC_1403 3909-7815 62.9 µM 0.168055467938495 0.444637752789883 no 1459 0.433269821219586 2022 6615483 SGTC_1182 1222-0449 220 µM 0.166347650978289 0.445305917810976 no 1460 0.433941684165624 2051 658318 SGTC_173 1273-0061 2.693 µM 0.165152738473412 0.445773506995471 no 1461 0.434411881792678 1944 2847414 YPL266W DIM1 SGTC_895 0964-0006 13.7 µM 0.163841227611409 0.446286809872066 no 1462 0.434928067629615 2110 6738897 SGTC_723 4182-0001 115 µM 0.163780658248077 0.446310517864265 no 1463 0.434951909270378 1964 744821 YLR208W SEC13 SGTC_2053 5265679 138 µM 0.163622329615392 0.446372491586283 no 1464 0.435014232561041 2028 764595 SGTC_3098 9119039 49.47 µM 0.162982459683856 0.446622965748718 no 1465 0.435266122574539 2142 17161528 SGTC_2927 9011802 47.9 µM 0.162769689324344 0.446706258457268 no 1466 0.435349887185682 1946 43912568 SGTC_185 k048-0037 25.491 µM 0.162463166588288 0.446826256318955 no 1467 0.435470565849716 2129 6827589 SGTC_3309 9129340 25.759 µM 0.162392209944897 0.446854035199015 no 1468 0.435498502490688 2054 17158987 SGTC_2376 9072922 81.32 µM 0.161384700407461 0.447248494086753 no 1469 0.43589520801372 2050 17087968 SGTC_197 4544-0043 41.561 µM 0.160914495431729 0.447432606042046 no 1470 0.436080372691553 2124 896523 SGTC_1481 3346-2004 36 µM 0.160666883914891 0.447529564570777 no 1471 0.436177886665959 2124 2770522 SGTC_2789 5281112 71.43 µM 0.160333023721548 0.447660300905109 no 1472 0.436309373097911 1967 765948 SGTC_2007 4011539 71.82 µM 0.158535977969812 0.448364103491084 no 1473 0.437017236402298 2030 45595301 SGTC_2478 5763493 32.33 µM 0.158490454406845 0.448381934651909 no 1474 0.437035170939495 2053 1365576 YLR208W SEC13 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.15610261997068 0.449317372769487 no 1475 0.437976066621998 2104 16486 A toxic proline analog. SGTC_2830 7992007 71.43 µM 0.156026813869235 0.449347074577851 no 1476 0.438005942821258 1944 1952075 SGTC_2307 7538926 6.34 µM 0.155142235342738 0.449693684790585 no 1477 0.438354593134865 2007 96582 SGTC_2408 sulbentine 18.36 µM 0.154626408063324 0.449895822515551 no 1478 0.438557924880283 2022 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_220 paclitaxel 373.376 µM 0.153941217921972 0.450164348721252 no 1479 0.438828042118017 2126 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2255 7941087 197.44 µM 0.152394237768045 0.450770694396656 no 1480 0.439438000796533 2149 935561 SGTC_2793 7325131 81.82 µM 0.15079022831266 0.451399514281414 no 1481 0.440070597400691 2047 4176441 SGTC_1331 1472-0049 76.2 µM 0.150744002251195 0.451417638101731 no 1482 0.440088830522965 1995 24051409 SGTC_550 4123-0385 25.7 µM 0.149160156288052 0.452038676432473 no 1483 0.440713629445319 2026 5731123 SGTC_1760 st045453 10.4495 µM 0.148334403804533 0.452362507055518 no 1484 0.441039432683149 2153 3323419 YIL048W NEO1 SGTC_2999 9069765 71.4286 µM 0.145997218474445 0.453279238731476 no 1485 0.441961792117942 2090 2097066 SGTC_668 1682-0499 62.6 µM 0.145934372953074 0.453303892560266 no 1486 0.441986598181791 2025 682214 SGTC_2659 sanguinarine 24.21 µM 0.145394368251315 0.453515739780213 no 1487 0.442199755451128 2077 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_202 3594-0513 34.79 µM 0.144726191025985 0.453777888186503 no 1488 0.442463529708582 2146 708429 SGTC_1809 st050081 57.6 µM 0.143108234039608 0.454412750354958 no 1489 0.443102351028525 2119 5036894 SGTC_2893 9048488 25.97 µM 0.142541985319909 0.454634965498491 no 1490 0.443325959217405 2010 6467338 SGTC_2295 7971645 200 µM 0.141273236179559 0.455132917003276 no 1491 0.443827045988213 2082 2978226 YKL099C UTP11 SGTC_2319 6033012 152.6 µM 0.140839851525392 0.455303025561325 no 1492 0.443998229930679 2052 847246 SGTC_1578 josamycin 24.2 µM 0.140654925821644 0.45537561356467 no 1493 0.444071277487676 1980 5282165 A P450 substrate. SGTC_3251 9135047 49.47 µM 0.13971168985834 0.455745880600653 no 1494 0.444443894914554 2137 17682963 SGTC_329 k048-0121 21.3 µM 0.139324981283472 0.455897694081337 no 1495 0.444596675093679 2056 6832902 SGTC_1790 st045711 43.5 µM 0.138349776277443 0.456280567165866 no 1496 0.444981993965718 2166 585119 SGTC_1453 4237-0541 195 µM 0.13559861402422 0.457360912567148 no 1497 0.446069300590852 2169 739892 SGTC_314 1671-0008 2.74 µM 0.133993071953924 0.457991534067046 no 1498 0.446704026406168 2106 3913060 SGTC_1344 1488-0097 29.1 µM 0.133816656404206 0.458060832680244 no 1499 0.446773777876409 2092 747966 SGTC_3269 9137823 49.47 µM 0.132558140686621 0.458555232960287 no 1500 0.44727141953853 2012 17682936 SGTC_2818 7996756 12.99 µM 0.131910217337746 0.458809790776315 no 1501 0.447527653492834 2110 2241621 SGTC_1504 k297-0033 30 µM 0.131758689214736 0.458869325981647 no 1502 0.447587581414977 2003 4388117 SGTC_746 1095-0025 46.6 µM 0.130323497669252 0.459433256463857 no 1503 0.448155245076892 2159 6749286 SGTC_2228 7354201 200 µM 0.129445921227366 0.459778123275036 no 1504 0.448502406712854 2131 753451 SGTC_1151 3909-8316 15.3 µM 0.128765377977839 0.460045581544244 no 1505 0.448771650889844 2080 800431 SGTC_604 1000-0114 314 µM 0.128588213732997 0.460115211305665 no 1506 0.448841746477317 2179 1572745 SGTC_704 1310-0270 142 µM 0.128549295006436 0.46013050745468 no 1507 0.448857145007186 2050 5718033 SGTC_568 1193-0097 7.48 µM 0.128104885982856 0.460305176819774 no 1508 0.449032984727533 2156 3646150 SGTC_868 0527-0199 213 µM 0.127832937654552 0.460412066462536 no 1509 0.449140591708161 2058 2849450 SGTC_2997 9067075 71.4286 µM 0.125314300825643 0.461402154865708 no 1510 0.450137365504003 2107 27209819 SGTC_590 k048-0076 22.4 µM 0.125145870062353 0.461468374422676 no 1511 0.450204034828429 2193 6832814 SGTC_934 2950-0684 338 µM 0.12386616219802 0.461971533947024 no 1512 0.450710622613386 2205 1121253 SGTC_3165 9101544 49.47 µM 0.123435507386576 0.462140873875611 no 1513 0.450881120612696 2153 5002184 SGTC_1119 parthenolide 318.541 nM 0.122504281210776 0.462507069393506 no 1514 0.451249827807891 2120 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2685 mycophenolic acid 18.85 µM 0.122450434227983 0.462528245163835 no 1515 0.451271149127384 2171 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1941 st076221 61.8 µM 0.11939850470731 0.463728613409457 no 1516 0.452479822946206 2218 2828568 SGTC_1238 0333-0287 48.8 µM 0.119320119463397 0.463759447862327 no 1517 0.452510872170889 2123 7226 SGTC_2132 5317594 122.667 µM 0.118591517172177 0.464046068997189 no 1518 0.452799493119551 2109 794577 SGTC_2871 9038510 12.99 µM 0.116793495468026 0.46475346311032 no 1519 0.453511849169925 2210 4945164 SGTC_1252 0493-0875 34.8 µM 0.114758614911092 0.465554178678027 no 1520 0.454318226392314 2144 3960963 SGTC_1776 st049249 45.9 µM 0.11164887259264 0.466778115457901 no 1521 0.455550909759114 2057 1822314 SGTC_147 4466-0538 29.23 µM 0.111023945241615 0.467024113537296 no 1522 0.455798679278658 2106 6742687 YHR072W ERG7 SGTC_219 mitoxanthrone 164.414 µM 0.108669917780032 0.467950871541169 no 1523 0.456732151325606 2172 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2950 9072895 21.46 µM 0.108280050334936 0.468104375513642 no 1524 0.456886773544812 2089 17332245 SGTC_1009 4106-0057 9.87 µM 0.108193900999244 0.468138296055506 no 1525 0.45692094142739 2223 2928005 SGTC_2796 7949634 45.45 µM 0.106249198933501 0.468904066439416 no 1526 0.457692318362581 2167 2971588 SGTC_1813 st051246 8.6015 µM 0.105799709723215 0.469081079446298 no 1527 0.457870633552775 2213 5291959 SGTC_608 k048-0125 159 µM 0.105509354380542 0.469195427316166 no 1528 0.457985823849593 2209 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1297 1068-0111 14.1 µM 0.104686529925226 0.469519486180002 no 1529 0.45831227539434 2144 767057 SGTC_294 k038-0071 157 µM 0.104541254999615 0.469576702950436 no 1530 0.458369915431659 2128 24152826 SGTC_3217 9129673 49.47 µM 0.103748610981087 0.469888898146315 no 1531 0.458684424394193 2153 17248312 SGTC_647 0140-0236 81 µM 0.103459244265552 0.47000287435801 no 1532 0.458799247114002 2151 990837 SGTC_1753 st043925 64 µM 0.103098016108505 0.470145158913977 no 1533 0.458942589775248 2211 670181 SGTC_1684 st024538 14.6195 µM 0.102958001174386 0.470200310576446 no 1534 0.458998151978358 2110 6732859 SGTC_1442 4112-3290 3 µM 0.101774091041819 0.4706666736646 no 1535 0.45946799559854 2230 704353 SGTC_283 0987-0079 11.7 µM 0.101747793962253 0.470677033007308 no 1536 0.459478432437051 2209 411556 SGTC_389 tpck 16.7 µM 0.100176552412578 0.471296035972223 no 1537 0.460102080412061 2134 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2810 7959871 45.46 µM 0.0974020956988758 0.472389223431598 no 1538 0.461203540258539 2183 2974535 SGTC_3197 9113331 49.47 µM 0.097145821284203 0.472490210929726 no 1539 0.461305296397398 2196 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3067 9117431 49.47 µM 0.0955491356148523 0.473119440476815 no 1540 0.461939332087502 2134 17150885 SGTC_3285 9112818 20.8695 µM 0.0951347255157496 0.473282764224166 no 1541 0.462103908089036 2229 17017947 YPR165W RHO1 SGTC_344 k064-0035 6.43 µM 0.0946860452544902 0.4734595992964 no 1542 0.462282101223814 2099 5088750 SGTC_2687 chenodiol 100 µM 0.0940097720916094 0.473726143767148 no 1543 0.462550697055552 2174 5702181 A cholesterol synthesis inhibitor. SGTC_756 0508-1999 28.3 µM 0.0937503436379076 0.473828397322722 no 1544 0.462653738954117 2051 6753853 SGTC_189 3970-0742 2.116 µM 0.0930177618015088 0.474117153262544 no 1545 0.462944725260999 2252 2891807 SGTC_2234 tolnaftate 200 µM 0.0926309551289426 0.474269623258972 no 1546 0.463098375415477 2253 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1503 4585-0012 61.3 µM 0.0921787929045739 0.474447859636776 no 1547 0.463277993554381 2199 2922052 SGTC_3320 9137005 35.139 µM 0.0906078372876392 0.475067149120414 no 1548 0.463902102148451 2084 4908713 SGTC_2285 7945142 200 µM 0.0905375369324195 0.475094863780215 no 1549 0.463930033132512 2167 2970608 SGTC_1540 guanosine 70.6 µM 0.0898978520730374 0.475347053634769 no 1550 0.464184194019936 2225 6802 Guanosine is a purine nucleoside SGTC_3221 9128209 49.47 µM 0.0897344922511343 0.475411458324782 no 1551 0.464249102823166 2173 16460723 SGTC_2484 5809818 12.04 µM 0.0883624881405232 0.475952396812892 no 1552 0.464794287381528 2192 2870548 SGTC_2774 tamoxifen 10.92 µM 0.0879953236739952 0.476097165885378 no 1553 0.464940196446769 2235 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_880 0833-0487 87.2 µM 0.0879261448186791 0.476124442731438 no 1554 0.464967688257759 2256 76075 SGTC_2956 9076196 2.52 µM 0.0870580275948631 0.476466746096568 no 1555 0.465312693895812 2266 16423868 SGTC_719 2810-4230 27.3 µM 0.085662860958587 0.477016904200764 no 1556 0.46586721311289 2259 721079 SGTC_1814 st052110 31.539 µM 0.0850620832821675 0.477253823297456 no 1557 0.466106017086044 2237 674163 SGTC_4 0960-0234 25.671 µM 0.0843961525507731 0.477516445155219 no 1558 0.466370733097099 2157 6821112 SGTC_396 dithiazanine 1.25 µM 0.0843179149543327 0.477547300213057 no 1559 0.46640183452455 2120 10578 An antihelmenthic. SGTC_920 mycophenolic acid 780.421 nM 0.0838792305565836 0.477720309453159 no 1560 0.4665762264858 2192 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1419 3993-2473 62.6 µM 0.0837083544526276 0.477787701054791 no 1561 0.466644157284538 2192 704026 SGTC_206 4546-0025 72.014 µM 0.082624537237616 0.478215161009993 no 1562 0.467075045043556 2150 6620745 YIL048W NEO1 SGTC_1498 4478-3555 97.6 µM 0.0825982036104109 0.478225547365834 no 1563 0.467085514853486 2270 3437919 SGTC_995 3931-2021 34.6 µM 0.0823445421833719 0.478325595784502 no 1564 0.467186367561292 2169 730143 SGTC_2339 9000433 200 µM 0.0821633945600412 0.47839704435129 no 1565 0.467258390949691 2145 2988954 SGTC_117 lucigenin 22.078 µM 0.0812275002839376 0.478766192439897 no 1566 0.467630514853918 2041 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2658 polymyxin b sulfate 77.05 µM 0.0807449597373805 0.478956529751091 no 1567 0.467822390411441 2192 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1178 0988-0033 191 µM 0.0806463736691594 0.478995417452565 no 1568 0.467861592715684 2208 5392207 SGTC_2537 larixol 68.93 µM 0.0804850029359862 0.479059071268317 no 1569 0.467925761730506 2233 6708759 SGTC_529 4076-0302 30.3 µM 0.0798897082615386 0.479293894028212 no 1570 0.468162487641989 2109 5816522 SGTC_2981 9013952 38.96 µM 0.078775307181199 0.479733505219287 no 1571 0.468605672506281 2053 2996344 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0786244407288279 0.479793021228894 no 1572 0.468665673411847 2269 1377 SGTC_682 0kpi-0099 17 µM 0.078519141052186 0.479834561655899 no 1573 0.468707552434609 2169 1714895 YML126C ERG13 SGTC_2664 lyso-paf C-16 73.48 µM 0.0782778588326904 0.479929747639699 no 1574 0.468803514751844 2258 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1798 st045719 60.953 µM 0.0776073303614411 0.480194277526388 no 1575 0.469070205592855 2264 3980186 SGTC_274 sirtinol 40.1 µM 0.0775120321644086 0.480231874286035 no 1576 0.469108109894517 2102 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2928 9011484 9.79 µM 0.077008836383655 0.480430396488244 no 1577 0.469308257713702 2187 2994751 SGTC_2740 felodipine 17.08 µM 0.0767525459039767 0.480531510791529 no 1578 0.469410201100845 2285 3333 L-type calcium channel blocker SGTC_70 0141-0289 43.283 µM 0.076695134802066 0.480554161370084 no 1579 0.469433037503959 2154 352408 SGTC_134 0269-0018 6.916 µM 0.0760343134418982 0.480814881755126 no 1580 0.469695899511823 2180 4378915 SGTC_3342 9147791 14.508 µM 0.0759990547813105 0.480828792934717 no 1581 0.469709925099998 2263 1838168 SGTC_657 3534-0529 86.7 µM 0.0758057048890612 0.48090507886414 no 1582 0.469786838671267 2270 1049549 SGTC_2119 5528445 120.635 µM 0.0757491731318173 0.480927383522096 no 1583 0.469809326920397 2238 791935 SGTC_1278 0874-0585 172 µM 0.0752629380370092 0.481119230493891 no 1584 0.47000275448822 2207 766306 SGTC_743 1275-0778 158 µM 0.0751544565356185 0.481162033118854 no 1585 0.470045910121348 2259 2849257 YMR203W TOM40 SGTC_1625 st003711 30.1 µM 0.0747626901444096 0.481316610862359 no 1586 0.470201763827773 2246 24207034 YER133W GLC7 SGTC_3123 9126162 49.47 µM 0.0742964977058757 0.481500558260728 no 1587 0.470387231878644 2273 25239884 SGTC_1284 0929-0043 16 µM 0.0741090481900628 0.481574522071646 no 1588 0.470461807823466 2181 1239883 SGTC_2596 sinensetin 100 µM 0.0738550201880654 0.481674757426565 no 1589 0.47056287337167 2209 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_729 4092-0585 94.1 µM 0.073844815320239 0.481678784127164 no 1590 0.470566933438386 2215 2169061 SGTC_1105 epirubicin 18.1 µM 0.07234865023022 0.482269170320435 no 1591 0.47116222441039 2235 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2491 paeonol 100 µM 0.0719198918632878 0.482438365439095 no 1592 0.471332829811772 2174 11092 Increases levels of cortical cytochrome oxidase. SGTC_3173 9105693 49.47 µM 0.0706392989866425 0.482943727206931 no 1593 0.471842416225379 2246 17096658 SGTC_1013 4112-3890 241 µM 0.0705423635141261 0.482981982084382 no 1594 0.471880991652051 2140 705171 SGTC_2492 derrusnin 100 µM 0.0681764102760055 0.483915736006863 no 1595 0.47282260257156 2235 1715307 Part of coumarin class of compounds. SGTC_2618 avocadyne 43.43 µM 0.0680957222189851 0.483947582172587 no 1596 0.472854717814545 2222 3015189 SGTC_2975 9084847 53.72 µM 0.0675487998584827 0.484163445557508 no 1597 0.473072407019511 2131 27211724 SGTC_496 calpeptin 138 µM 0.0666974317098507 0.484499479083331 no 1598 0.473411289479821 2171 73364 A calpain inhibitor. SGTC_3150 9097574 49.47 µM 0.0662218469861481 0.484687196353431 no 1599 0.473600601785026 2266 17217476 SGTC_3263 9137018 49.47 µM 0.065678823071257 0.48490153658393 no 1600 0.473816766371585 2208 43844957 SGTC_2218 6965428 192.983 µM 0.0654463332512522 0.484993305374309 no 1601 0.473909317263665 2261 675684 SGTC_1604 st002052 72.4 µM 0.0654156321696186 0.485005423818726 no 1602 0.473921539033158 2219 6254834 YHR062C RPP1 SGTC_3236 9132701 49.47 µM 0.0646407940380225 0.485311275345418 no 1603 0.474230001833193 2204 24282524 SGTC_1299 1079-1439 3.74 µM 0.0637590702031375 0.485659328322165 no 1604 0.47458103457952 2251 323161 SGTC_2416 tofa 880 nM 0.0628332908620238 0.486024783587774 no 1605 0.474949627980339 2050 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1080 nisoldipine 24.4 µM 0.0620420525136834 0.486337137548536 no 1606 0.475264671711132 2294 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0616506415193546 0.486491656393642 no 1607 0.475420523754841 2235 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2327 6189656 200 µM 0.0615743926942885 0.486521757676501 no 1608 0.475450884953152 2282 5349088 SGTC_863 0466-0191 129 µM 0.0609654616825414 0.486762152379207 no 1609 0.475693357726569 2310 765160 YPR165W RHO1 SGTC_601 0986-0029 62.9 µM 0.0608784708708903 0.486796495137677 no 1610 0.475727997696767 2267 24747981 SGTC_3001 9076041 71.4286 µM 0.0601789064293169 0.487072676954873 no 1611 0.476006572746222 2289 16004211 SGTC_1873 rapamycin 2 nM 0.0598205280318489 0.487214163967534 no 1612 0.47614928792436 2264 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_151 3013-0144 2.285 µM 0.0588452708697983 0.487599201473117 no 1613 0.476537674985642 2307 906558 YHR107C CDC12 SGTC_1282 0886-0010 32.4 µM 0.0569801701651719 0.488335586551025 no 1614 0.477280495694453 2299 2836211 YNL267W PIK1 SGTC_467 ro 31-8220 72.8 µM 0.0569114544598732 0.488362717882444 no 1615 0.477307864881873 2302 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1963 st076565 50.3 µM 0.0551809538950027 0.489045996636701 no 1616 0.477997151201826 2313 4914280 SGTC_1346 1488-2224 62.4 µM 0.0545050404525037 0.489312886232182 no 1617 0.478266396430439 2308 3722427 SGTC_3159 9100096 49.47 µM 0.0536237689545826 0.48966087019642 no 1618 0.478617459433491 2313 25236875 SGTC_260 nsc-65238 3.989 µM 0.0522781991702355 0.490192204761702 no 1619 0.479153512050345 2305 3246252 SGTC_2346 9031566 143.75 µM 0.0519305939912776 0.490329468920192 no 1620 0.479291998338768 2288 4771086 SGTC_3211 9128781 49.47 µM 0.0512710306609437 0.490589923886647 no 1621 0.479554775958501 2130 17194361 SGTC_2957 9076800 11.52 µM 0.0510908574169854 0.490661073202179 no 1622 0.479626560602075 2273 16459615 SGTC_632 0781-2353 4.65 µM 0.0504021404650095 0.4909330460467 no 1623 0.479900965355919 2264 6811515 YHR007C ERG11 SGTC_3219 9131112 49.47 µM 0.0496161591314437 0.491243433529791 no 1624 0.480214134683545 2326 17612988 YMR079W SEC14 SGTC_2264 7948757 110.76 µM 0.0495796843482826 0.491257837712164 no 1625 0.480228668129914 2322 2971411 SGTC_1187 1391-0724 117 µM 0.0494614502550601 0.491304529375525 no 1626 0.480275778908664 2218 6997986 SGTC_1205 4161-2785 76 µM 0.0493338228109716 0.491354930687879 no 1627 0.480326632809376 2149 3498106 SGTC_3089 9117425 49.47 µM 0.0487594113245661 0.491581773037749 no 1628 0.480555514373496 2176 9401657 SGTC_1660 st012960 28.1 µM 0.0463137326186586 0.492547632025959 no 1629 0.481530097003945 2266 24207266 SGTC_1325 1431-0015 227 µM 0.0462372800948536 0.492577825751593 no 1630 0.481560564508756 2305 1103340 SGTC_3066 9117245 49.47 µM 0.0461575849447156 0.492609300146924 no 1631 0.481592324364606 2295 17176980 SGTC_2816 7982706 58.44 µM 0.0460834648552789 0.492638572797574 no 1632 0.48162186256999 2273 2981853 SGTC_2576 guaiol 23.12 µM 0.0457425409620047 0.492773216235826 no 1633 0.481757728246581 2319 227829 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0455578546530888 0.492846156025836 no 1634 0.481831330692185 2286 5393153 SGTC_1050 3232-1156 69.3 µM 0.0452207921065609 0.492979275719818 no 1635 0.481965660748441 2263 700529 SGTC_1431 4049-0260 9.09 µM 0.0451686154110385 0.492999882487 no 1636 0.48198645499073 2319 3854841 SGTC_495 decylubiquinone 155 µM 0.0443577944388959 0.493320112089665 no 1637 0.482309601835418 2197 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1958 st076513 41.9 µM 0.0436693615984703 0.493592008512022 no 1638 0.48258398090563 2316 732122 YGL099W LSG1 SGTC_3314 9135860 59.4275 µM 0.0429497038471942 0.493876240387743 no 1639 0.482870813669315 2313 25252478 SGTC_1376 2910-0861 41.3 µM 0.0429411010641943 0.493879638112403 no 1640 0.482874242519797 2333 1112859 SGTC_2054 5233173 129 µM 0.0426264063100084 0.494003929139492 no 1641 0.482999672712774 2299 6889 SGTC_1306 1185-0270 9.02 µM 0.0425376307382424 0.494038991815751 no 1642 0.483035056947413 2314 1548076 SGTC_2091 4-phenylthiadiazole 200 µM 0.0424209680893228 0.494085068803167 no 1643 0.483081556637519 2306 270010 SGTC_1988 st071872 53.4 µM 0.0418855561173599 0.494296535694289 no 1644 0.483294965421002 2341 16414116 SGTC_2739 tacrine 100.86 µM 0.0405255439902207 0.494833694623022 no 1645 0.483837071303155 2287 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2070 5230947 200 µM 0.0399714768327246 0.495052535206995 no 1646 0.484057933151413 2334 2835538 SGTC_2892 9047358 58.44 µM 0.0389630805180031 0.495450826509378 no 1647 0.484459911863487 2311 6466771 SGTC_1808 st050063 61.5 µM 0.0389171400305246 0.495468971962973 no 1648 0.484478225576222 2333 4011993 SGTC_471 1-acyl-paf 4 µM 0.0386744275276019 0.49556483806731 no 1649 0.484574981014052 2318 16759367 SGTC_2589 lobaric acid 100 µM 0.0383979623074756 0.495674036064848 no 1650 0.484685192814307 2305 73157 A novel microtubule depolymerizer. SGTC_2482 5981709 142.65 µM 0.0383495285593602 0.495693166419088 no 1651 0.484704500863013 2312 877755 SGTC_2120 5538279 151.968 µM 0.0382956186929758 0.495714459741309 no 1652 0.484725992001093 2316 2058197 SGTC_520 3584-0023 682 µM 0.0369268792506347 0.496255088452525 no 1653 0.485271653908091 2179 1340790 SGTC_1731 st035964 63 µM 0.0367116816295932 0.496340088489821 no 1654 0.485357447164669 2149 6739575 SGTC_1826 st055655 41.6 µM 0.0363898131741499 0.496467222317153 no 1655 0.48548576835528 2232 676168 SGTC_265 mycophenolic acid 32.932 µM 0.0363756275824198 0.496472825448577 no 1656 0.485491423843263 2315 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2175 5807670 165.306 µM 0.0362855245983571 0.496508415017261 no 1657 0.485527346018327 2334 241186 SGTC_46 0329-0187a 2.197 µM 0.0359178179818092 0.496653654885935 no 1658 0.485673944169558 2300 46494817 SGTC_78 0336-0123 156.75 µM 0.0355996125082083 0.496779342733295 no 1659 0.485800808650464 2253 6765896 SGTC_1630 st005209 31.3 µM 0.0349685571316939 0.497028603966955 no 1660 0.486052406652942 2348 3367314 SGTC_2387 9077560 195.08 µM 0.0346154015339533 0.497168097784206 no 1661 0.486193210105905 2349 5303272 SGTC_2377 9073351 62.6 µM 0.0340462287219713 0.497392917505281 no 1662 0.486420143430626 2330 7337946 YHR072W ERG7 SGTC_301 4119-0100 24.5 µM 0.0340169909098558 0.497404466282206 no 1663 0.486431800877571 2333 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2681 menadione 3.18 µM 0.0332203656257326 0.497719129745495 no 1664 0.486749428831901 2307 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_836 0330-0104 1.35 µM 0.032985066730581 0.497812072048476 no 1665 0.486843248092313 2356 46494820 SGTC_1085 doxorubicin 7.67 µM 0.0328167800271308 0.497878544825485 no 1666 0.486910348446554 2354 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1792 st045773 43.6 µM 0.0327874963546694 0.497890111800242 no 1667 0.486922024658247 2330 2919270 SGTC_1210 3013-0140 750 nM 0.0325509692052009 0.497983539475691 no 1668 0.487016334997271 2356 905973 SGTC_2406 ethylparaben 405.7 µM 0.0322231717266515 0.498113018901188 no 1669 0.487147038703291 2269 8434 A possible steroid mimic. SGTC_993 3909-8757 62.7 µM 0.0320381777276137 0.49818609129293 no 1670 0.487220802545027 2316 4288324 YLR208W SEC13 SGTC_2256 7954252 200 µM 0.0304767984311405 0.498802836289512 no 1671 0.487843398476993 2244 2972920 SGTC_832 4083-0019 164 µM 0.0291154457879577 0.499340573121925 no 1672 0.488386258531508 2321 1990758 SGTC_1353 1498-1206 8.11 µM 0.0289770286974937 0.499395248214235 no 1673 0.488441455671799 2344 6756808 SGTC_2553 4-methylesculetin 85.09 µM 0.0289638445391047 0.499400455989943 no 1674 0.488446713183271 2347 5319502 SGTC_3061 glucosamine 200 µM 0.0286006159034313 0.499543932251245 no 1675 0.488591560433324 2348 91431 and experimental redox chemotherapeutic SGTC_565 1418-0001 44.5 µM 0.0285626830397201 0.499558915835366 no 1676 0.488606687276572 2357 2862145 SGTC_1394 3474-0001 65.7 µM 0.0283398416772125 0.499646938790245 no 1677 0.488695552143521 2317 5017666 YIL048W NEO1 SGTC_2580 diallyl disulphide 81.36 µM 0.027447204040164 0.49999953325643 no 1678 0.489051524517357 2336 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1201 1889-3372 45.9 µM 0.0274448407993161 0.49999953325643 no 1679 0.48905246695902 2289 5392199 SGTC_3352 9151559 45.5865 µM 0.0274417243256346 0.499998302240089 no 1680 0.489053709784043 2334 17159339 SGTC_1157 4092-0394 27.6 µM 0.0262568835742151 0.49953028674012 no 1681 0.489526222483312 2354 3659885 SGTC_2837 9008476 45.46 µM 0.0258947184669446 0.499387230581769 no 1682 0.489670656344237 2323 2992805 SGTC_213 1246-0773 967 nM 0.0235919260660659 0.498477624212205 no 1683 0.490589056213147 2310 6251622 SGTC_421 streptovitacin 30 mM 0.0226457215610771 0.498103874072423 no 1684 0.490966436317481 2279 91467 include heat shock SGTC_76 0433-0009 400.328 µM 0.022554778683948 0.498067951779898 no 1685 0.491002708011803 2239 2841569 SGTC_3042 9091578 49.47 µM 0.0219141126100674 0.497814890155256 no 1686 0.491258233621946 2358 25236497 SGTC_2741 miltefosine 3.04 µM 0.0214932344333082 0.497648644716316 no 1687 0.491426100178934 2357 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_187 1488-2104 32.728 µM 0.020906609602172 0.497416930603849 no 1688 0.491660077038652 2341 2852859 SGTC_2457 5731572 11.68 µM 0.0200324130153542 0.497071628610035 no 1689 0.492008757950956 2375 2865357 SGTC_883 0850-0245 24.6 µM 0.0196903181507137 0.496936503935568 no 1690 0.492145207140232 2336 6823229 YPR165W RHO1 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0187829002510127 0.49657808302844 no 1691 0.492507147520305 2372 2346 DNA damaging agent; causes G2/M arrest. SGTC_502 l-744,832 89.3 µM 0.0180995151746465 0.496308154631931 no 1692 0.492779732361745 2377 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_773 4358-1457 44.6 µM 0.0178872426664415 0.496224310034532 no 1693 0.492864403132391 2374 1186886 SGTC_464 bw-b 70c 158 µM 0.0176090247295514 0.496114418191391 no 1694 0.492975378550428 2366 5353454 SGTC_2279 7948423 32.93 µM 0.0175984860117358 0.496110255564279 no 1695 0.49297958223915 2368 1247112 SGTC_1600 coumarin 106 71.1 µM 0.0175979548782584 0.496110045774954 no 1696 0.492979794097942 2346 100336 A hepatotoxic, DNA x-linker. SGTC_2488 5268135 45.7 µM 0.0170834591371437 0.495906828606883 no 1697 0.49318501734225 2363 1270356 YLR208W SEC13 SGTC_1291 0993-0025 5.79 µM 0.014984797993969 0.495077904301291 no 1698 0.494022154232839 2378 4353356 SGTC_1545 lovastatin 49.4 µM 0.0144143838325374 0.494852606963154 no 1699 0.494249691971814 2372 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_159 3970-0959 50 µM 0.01426777927114 0.494794702601666 no 1700 0.494308172715725 2371 6615653 SGTC_322 k048-0136 19.3 µM 0.014020388010517 0.494696990795865 no 1701 0.494406857677429 2342 6823282 SGTC_2700 st077718 96.8 µM 0.0139743082190581 0.494678790755286 no 1702 0.494425239053732 2373 904970 SGTC_110 0850-0284 111.64 µM 0.0127070531260068 0.494178270086282 no 1703 0.494930755670233 2386 3906265 SGTC_1368 1852-0141 284 µM 0.0122360123828616 0.493992228048159 no 1704 0.49511865912299 2354 2838987 SGTC_1714 st033236 13.627 µM 0.0118488124365922 0.493839300709854 no 1705 0.49527311835134 2383 2916566 SGTC_994 3910-0338 138 µM 0.0116069799239659 0.493743787718377 no 1706 0.495369588930486 2383 3479481 SGTC_2365 9042475 200 µM 0.01000390001158 0.493110652411778 no 1707 0.496009087883677 2375 6464479 SGTC_741 4582-0002 126 µM 0.00993366560153659 0.493082913765151 no 1708 0.496037105967171 2381 2912688 SGTC_3353 9151644 39.2805 µM 0.00870911519194797 0.492599290634513 no 1709 0.496525609646426 2377 4909158 SGTC_3106 9121286 49.47 µM 0.00852880981594101 0.492528081850026 no 1710 0.496597538412483 2371 15943471 SGTC_1422 4031-0024 15.5 µM 0.00829099993291236 0.492434162925571 no 1711 0.496692407474359 2389 782427 SGTC_2015 5119600 184 µM 0.00816460306036127 0.492384244824366 no 1712 0.49674283082412 2384 2828786 SGTC_2557 derrustone 83.84 µM 0.00754094483903022 0.492137944334548 no 1713 0.496991626781846 2364 629853 An antioxidant. SGTC_34 0469-0683 81.75 µM 0.0066498971492448 0.491786049310995 no 1714 0.497347094419274 2388 3690923 SGTC_613 3914-0030 117 µM 0.00664927782485302 0.491785804727881 no 1715 0.497347341488497 2378 1145395 SGTC_154 3389-1638 511.116 µM 0.0057832549691508 0.49144379870888 no 1716 0.497692827935432 2372 5238686 SGTC_997 3996-0078 137 µM 0.00528848684536464 0.491248409817994 no 1717 0.497890208832514 2397 735687 SGTC_2906 7926292 26.41 µM 0.0051260807254596 0.491184274469017 no 1718 0.49795499862185 2385 2966319 SGTC_1476 4112-3294 3.34 µM 0.00405864031532946 0.490762740294987 no 1719 0.498380841222556 2393 704369 SGTC_1324 1418-0026 34.4 µM 0.00333124420403403 0.490475496119396 no 1720 0.498671028298644 2376 1372513 SGTC_3004 9076122 71.4286 µM 0.00319755441381768 0.490422703390206 no 1721 0.498724362524206 2399 44782551 SGTC_2828 7998861 71.43 µM 0.00310152538027061 0.49038478261167 no 1722 0.498762672375809 2400 2988188 SGTC_1281 0884-0031 11.8 µM 0.00236821191574391 0.490095208314644 no 1723 0.49905522102098 2402 1548255 SGTC_333 3486-0131 40.1 µM 0.00222120970159861 0.490037160006748 no 1724 0.499113866265058 2403 6744690 SGTC_2868 9035608 32.47 µM 0.00168285060204703 0.489824574306882 no 1725 0.499328640060125 2403 6462614 SGTC_169 k015-0017 16.025 µM 0.0012627884161922 0.489658703358142 no 1726 0.49949622044347 2395 1840002 SGTC_2517 totarol 10 µM 0.00115175215526669 0.489614858504884 no 1727 0.499540517470307 2400 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.000394538208530494 0.489315861046467 no 1728 0.499842602031467 2404 442882 SGTC_959 1222-0044 107 µM 0.000106675401652522 0.489202195599372 no 1729 0.499957442672083 2405 6083612 SGTC_2396 5342950 42.78 µM -0.000421960606436105 0.488993460787606 no 1730 0.499831662078424 2406 1886677 SGTC_3247 9135149 49.47 µM -0.00114816049239561 0.488706721727579 no 1731 0.499541950335536 2409 8934436 YOR116C RPO31 SGTC_2362 9071156 126 µM -0.00126134380898796 0.488662031967434 no 1732 0.499496796757904 2407 653133 SGTC_2920 7982904 15.77 µM -0.00237253265113147 0.488223293301201 no 1733 0.499053497301794 2414 6456808 SGTC_1774 st048371 48.465 µM -0.00423799108824526 0.487486773271936 no 1734 0.498309291231951 2409 4242727 SGTC_1090 efavirenz 20.7 µM -0.00480134946195494 0.48726435647571 no 1735 0.498084546056126 2413 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_289 k017-0060 526 µM -0.00506760586783781 0.487159238445449 no 1736 0.497978326411888 2414 5512909 SGTC_1870 st057514 26.5 µM -0.0062267356057411 0.486701624510431 no 1737 0.4975159079503 2418 5393161 SGTC_295 k015-0027 31 µM -0.00732381151141618 0.486268524985992 no 1738 0.497078248054022 2432 3887424 SGTC_1791 st048313 56.1 µM -0.00760468079125591 0.486157647045371 no 1739 0.496966200544802 2421 1204976 SGTC_2393 9031399 185.94 µM -0.00775861005394732 0.486096881295855 no 1740 0.496904793465555 2424 1526623 YDL150W RPC53 SGTC_2426 5582046 32.21 µM -0.00795882248927044 0.486017845093769 no 1741 0.496824922726599 2423 2251934 SGTC_3102 9121669 49.47 µM -0.00827023267205961 0.485894913372092 no 1742 0.496700692128723 2421 41905072 SGTC_1058 3448-5425 97.3 µM -0.00850499537054742 0.485802239758484 no 1743 0.496607038657066 2421 7279705 SGTC_2428 5615643 7.78 µM -0.00992826946777647 0.485240412610066 no 1744 0.496039258606925 2439 2253075 SGTC_2821 7996764 71.43 µM -0.0108350948973048 0.484882465044995 no 1745 0.495677507109729 2428 2987135 SGTC_2846 9008642 19.48 µM -0.0114734829915036 0.484630483961994 no 1746 0.495422842954888 2445 2992898 SGTC_2260 7964312 200 µM -0.0124248469595014 0.484254978160222 no 1747 0.49504333075314 2432 231951 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0125968400466779 0.484187093527629 no 1748 0.494974720808479 2426 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0130864208318781 0.483993861464833 no 1749 0.494779422439285 2431 2724278 An inhibitor of dopamine biosynthesis. SGTC_2588 indole-3-carbinol 100 µM -0.0137895544204437 0.483716349085679 no 1750 0.494498938053823 2442 3712 Induces cell cycle arrest. SGTC_984 1492-0255 2.91 µM -0.014276473184613 0.483524176869356 no 1751 0.494304704699283 2452 1585198 SGTC_2984 9022109 38.96 µM -0.0147598640137111 0.483333400808785 no 1752 0.494111879984074 2431 6459207 SGTC_1228 0124-0032 52.5 µM -0.0149333129492546 0.48326494800809 no 1753 0.494042691496007 2448 X1228 SGTC_3111 9122088 49.47 µM -0.015759575753993 0.482938864585876 no 1754 0.493713099151833 2438 16876704 SGTC_1789 tunicamycin 25 nM -0.0160241103130538 0.482834468805556 no 1755 0.493607578457406 2467 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3170 9103054 49.47 µM -0.0162767322388725 0.482734775319084 no 1756 0.493506810033387 2446 16432970 SGTC_1338 1486-1223 76 µM -0.0165146909919722 0.482640869422904 no 1757 0.493411890984905 2473 3444526 SGTC_99 0109-0120 622.8 µM -0.0178360351793209 0.48211944373429 no 1758 0.492884828705546 2440 759414 SGTC_2594 a-mangostin 100 µM -0.0181920763162491 0.481978948824623 no 1759 0.492742811887752 2463 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2334 9017922 200 µM -0.0189949242135554 0.481662150855612 no 1760 0.492422577285642 2458 3163164 SGTC_2404 5161160 200 µM -0.0201202061055199 0.481218142300232 no 1761 0.491973740633093 2444 2831543 SGTC_2388 9080168 200 µM -0.0201665396524707 0.48119986071793 no 1762 0.49195525997191 2445 15943073 SGTC_1765 st044815 90.4 µM -0.0201910472310644 0.481190190908387 no 1763 0.491945484852957 2470 645695 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0206028929403461 0.481027693056256 no 1764 0.491781216362072 2444 229346 A bile salt which induces apoptosis. SGTC_82 0054-0107 293.755 µM -0.0208712320379446 0.480921818870418 no 1765 0.49167418756592 2513 3104697 SGTC_1804 st050076 49.1 µM -0.022386736080475 0.480323896610606 no 1766 0.491069730388052 2458 3895976 SGTC_940 3232-1287 54.8 µM -0.0233616174859976 0.479939293239889 no 1767 0.490680910726372 2448 1585493 YIL048W NEO1 SGTC_199 4063-0024 41.6 µM -0.0241767455533904 0.479617728955505 no 1768 0.490355813534046 2522 306215 SGTC_1469 k284-2957 126 µM -0.0244022447280479 0.479528772898775 no 1769 0.490265878912979 2473 23884841 SGTC_2293 7624732 200 µM -0.025210555676207 0.479209914710433 no 1770 0.48994350871054 2457 894453 SGTC_2706 st078239 82.5 µM -0.0259963838896398 0.478899938144078 no 1771 0.489630111357851 2445 15434492 SGTC_1386 3228-0095 33.8 µM -0.0277203473344262 0.478219951193435 no 1772 0.488942597556229 2467 870181 SGTC_2622 2-methoxyxanthone 59.94 µM -0.0277823416531701 0.478195499797727 no 1773 0.488917874923083 2486 71034 A hepatoprotective. SGTC_3205 9113483 49.47 µM -0.0280909719276776 0.478073773076734 no 1774 0.488794797295816 2475 17018033 SGTC_1945 st075991 56.6 µM -0.0283607789668812 0.477967360284937 no 1775 0.488687202729489 2478 1084980 SGTC_150 3970-0969 77.2 µM -0.0289385845983609 0.477739477119634 no 1776 0.488456786219276 2549 6615640 SGTC_1313 1220-0047 237 µM -0.0300788644435293 0.47728977883599 no 1777 0.488002078417055 2479 3528706 SGTC_500 h-89 112 µM -0.0313489039255483 0.476788940613655 no 1778 0.487495644930424 2466 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_45 0kpi-0036 14.9 µM -0.0322075095512895 0.476450371456516 no 1779 0.487153283765755 2481 2795021 SGTC_3131 9127911 49.47 µM -0.0326135844160703 0.476290252131253 no 1780 0.486991368398111 2530 45595681 SGTC_2799 7812892 81.82 µM -0.0327813414178107 0.476224105006465 no 1781 0.486924478803559 2490 20205235 SGTC_3043 9092303 49.47 µM -0.032825975959056 0.476206505573719 no 1782 0.486906681775981 2471 25236084 SGTC_1711 st032263 62.8 µM -0.0330392015352963 0.476122431211818 no 1783 0.4868216631947 2496 3958979 SGTC_2973 9094665 17.96 µM -0.0337334688223937 0.475848690577326 no 1784 0.4865448449459 2483 25237061 YIL048W NEO1 SGTC_670 4204-0025 119 µM -0.033931707142725 0.475770529851464 no 1785 0.48646580454796 2508 719039 SGTC_752 1896-0090 130 µM -0.036739185948362 0.474663708235937 no 1786 0.485346481926237 2471 772567 SGTC_3075 9116269 49.47 µM -0.037144170331713 0.474504062958769 no 1787 0.485185026739457 2516 17015205 YNL244C SUI1 SGTC_253 dyclonine 31.25 µM -0.0372556187323341 0.474460130597252 no 1788 0.485140596013361 2468 3180 An oral anasthetic. SGTC_662 k832-1615 104 µM -0.040595608663305 0.473143670993713 no 1789 0.483809142525815 2516 5878478 SGTC_391 gliotoxin 8.33 µM -0.0422724919916358 0.472482835821207 no 1790 0.483140736944254 2540 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1161 k007-0610 110 µM -0.0423442008222952 0.472454578096456 no 1791 0.483112154852201 2480 5843850 SGTC_1831 st055328 12 µM -0.0424260707237126 0.472422316449413 no 1792 0.483079522811937 2484 1103068 SGTC_1068 loratadine 26.9 µM -0.0428849615951924 0.472241489303074 no 1793 0.48289661831526 2516 3957 A H1 histamine antagonist. SGTC_269 exalamide 29 µM -0.0429630420093873 0.472210722080482 no 1794 0.482865497419641 2497 3316 A derivative of salicylamide. SGTC_3047 9092122 49.47 µM -0.0430808634075622 0.472164295422691 no 1795 0.4828185369618 2494 17173831 SGTC_2504 purpurogallin 52.29 µM -0.0442107788444892 0.471719079828598 no 1796 0.482368195090117 2523 5281571 An antioxidant. SGTC_918 glabranin 770.725 nM -0.0444335551224235 0.471631304427698 no 1797 0.482279407466429 2513 124049 Also referred to as licorice root. SGTC_1234 0326-0494 15.5 µM -0.0462856065551273 0.470901637044665 no 1798 0.481541305659658 2557 1547813 SGTC_1410 3909-8106 77.9 µM -0.0477723614817868 0.470315958982452 no 1799 0.480948831870383 2515 1039210 SGTC_1887 st057648 70.8 µM -0.0487555246320157 0.46992869625332 no 1800 0.480557063097507 2490 688672 SGTC_1301 naphtanilide LB 4.81 µM -0.0489492079711612 0.469852408759398 no 1801 0.480479886772323 2508 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3204 9114183 49.47 µM -0.0492386514666822 0.469738405565528 no 1802 0.480364554595965 2492 17027248 SGTC_1961 st076550 68.7 µM -0.0500235502317259 0.469429269771392 no 1803 0.480051810720646 2548 1579337 SGTC_785 1270-0111 65.3 µM -0.05005881855572 0.469415379619733 no 1804 0.48003775830054 2488 6741994 SGTC_1206 3978-0017 132 µM -0.0514093578449062 0.468883508517382 no 1805 0.479499664076593 2697 3873677 SGTC_1217 1183-1422 255 µM -0.0528877678994379 0.468301342883346 no 1806 0.478910665279427 2553 2849664 SGTC_1298 1079-1278 263 µM -0.0533072274215172 0.468136181161753 no 1807 0.478743560870914 2508 2840950 SGTC_1877 wortmannin 25 µM -0.0536492201051492 0.468001525979245 no 1808 0.478607320488172 2503 312145 A covalent inhibitor of PI 3-kinase. SGTC_3260 9137109 49.47 µM -0.0551973796084761 0.467392004283963 no 1809 0.477990608262214 2476 17478346 SGTC_1445 4239-0156 97.7 µM -0.0567176597299606 0.466793533291879 no 1810 0.477385053114935 2617 4008346 SGTC_1354 1498-1681 81 µM -0.0582777791760076 0.466179457271235 no 1811 0.476763683537825 2561 5754243 SGTC_1054 3429-0080 167 µM -0.0585068708010167 0.466089291641757 no 1812 0.47667244488195 2533 1162877 SGTC_1473 k844-0725 134 µM -0.0588988638963506 0.465935015470605 no 1813 0.476516331480929 2496 54682906 SGTC_25 0118-0223 35.662 µM -0.0600376829028775 0.465486841197868 no 1814 0.476062811095261 2518 5333628 SGTC_3003 9075612 71.4286 µM -0.0601259393089119 0.465452110325449 no 1815 0.476027665375603 2582 6501993 SGTC_2403 6032726 181.2 µM -0.0606375566375628 0.465250782640707 no 1816 0.475823931335392 2546 2881040 SGTC_3292 9120825 59.784 µM -0.0607404367741431 0.465210299119415 no 1817 0.475782963613847 2512 24824900 SGTC_412 gemfibrozil 100 µM -0.0626718152743283 0.464450365446969 no 1818 0.475013920706136 2508 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_56 0957-0365 83.25 µM -0.0630627365844292 0.464296566506689 no 1819 0.474858273554012 2510 6752360 SGTC_1027 k015-0025 8.67 µM -0.0631701758659183 0.464254297942014 no 1820 0.474815496771641 2521 3598955 SGTC_1733 st037357 54.9 µM -0.065540290936721 0.463321955086413 no 1821 0.47387191387502 2520 1272339 YGL099W LSG1 SGTC_2087 5276107 200 µM -0.0662668354318136 0.463036191100958 no 1822 0.473582693329015 2521 144405 SGTC_1136 pergolide 1.05886 µM -0.066927948343808 0.462776179191755 no 1823 0.473319531677584 2545 47811 A dopamine receptor agonist. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0671751075818365 0.462678976961953 no 1824 0.473221150812183 2727 6710655 SGTC_2717 st081029 62.2815 µM -0.0675893523327564 0.462516068717521 no 1825 0.473056265812026 2516 5292846 SGTC_692 k241-0027 77.8 µM -0.0697420215756848 0.461669599619885 no 1826 0.472199497404544 2591 3600480 SGTC_956 1185-0240 191 µM -0.0704554531728647 0.461389103320375 no 1827 0.471915577806637 2570 1416193 SGTC_81 0411-0046 9.971 µM -0.0707801219801577 0.461261461274936 no 1828 0.471786376250623 2520 12925265 SGTC_579 4491-1009 110 µM -0.0734291058509737 0.460220175743478 no 1829 0.47073232849319 2518 1271041 SGTC_1170 0310-0127 64.8 µM -0.0734899036415274 0.46019627999586 no 1830 0.470708139038878 2605 774975 SGTC_3158 9100007 49.47 µM -0.074500328079064 0.459799167477766 no 1831 0.470306140062356 2562 19297233 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0756564893430349 0.459344827336696 no 1832 0.469846196602353 2589 23847180 SGTC_2905 7799065 20.05 µM -0.0777643522690253 0.458516631202379 no 1833 0.469007751657219 2590 1296806 SGTC_1010 4112-3296 15.2 µM -0.0781260658390183 0.458374529058764 no 1834 0.468863886509148 2548 704384 SGTC_1424 4048-1941 275 µM -0.0783996129964619 0.458267067345438 no 1835 0.468755090684556 2632 X1424 SGTC_2357 9067248 200 µM -0.0797621678675985 0.457731839667742 no 1836 0.468213207043265 2607 9150235 SGTC_659 k018-0002 107 µM -0.0822677528714185 0.45674781698243 no 1837 0.467216898476352 2585 6797879 YHR007C ERG11 SGTC_1122 capsaicin 818.572 nM -0.0838838711055089 0.456113256396896 no 1838 0.466574381676205 2675 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2340 7987427 183.45 µM -0.0848431998720851 0.455736633679735 no 1839 0.466193024401704 2630 2239331 SGTC_1363 1636-0063 10.4 µM -0.0850506866003069 0.455655181720044 no 1840 0.466110547287548 2564 6072185 SGTC_2261 9010538 184.68 µM -0.0854158403309316 0.455511839793558 no 1841 0.465965400210707 2672 6457250 SGTC_3322 9139058 2.11 µM -0.0863667820832448 0.455138572673487 no 1842 0.465587426145572 2696 4908926 YPR165W RHO1 SGTC_2528 xanthyletin 44.79 µM -0.0864329476257748 0.455112602603591 no 1843 0.465561128252619 2594 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1652 st011932 78 µM -0.0876742367496092 0.454625430528934 no 1844 0.465067798424108 2555 1551076 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0877146686047862 0.454609563273877 no 1845 0.465051730350831 2557 803109 SGTC_968 1309-0633 340 µM -0.0878785499450948 0.454545249701977 no 1846 0.464986602649744 2557 3761976 SGTC_3182 9108849 49.47 µM -0.088047357011859 0.454479004324507 no 1847 0.464919518407869 2621 17133045 SGTC_2236 dapsone 200 µM -0.0889982077367752 0.454105883311888 no 1848 0.464541667243999 2570 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_870 0573-2213 57.6 µM -0.0900381291984806 0.453697856646979 no 1849 0.464128457572815 2555 3916321 SGTC_937 3122-0005 46.7 µM -0.0913212690928512 0.453194467471551 no 1850 0.463618659153963 2579 759535 SGTC_3276 9139060 49.47 µM -0.0923683144088441 0.452783756346103 no 1851 0.46320270660852 2554 4870619 SGTC_2022 5136654 200 µM -0.0927628519056646 0.45262900922749 no 1852 0.463045981800609 2681 1713771 SGTC_603 3794-0023 45.9 µM -0.09296813162646 0.452548496415812 no 1853 0.462964439410748 2581 3802260 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0940976518953364 0.452105521973073 no 1854 0.46251579281142 2630 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1246 0422-0085 105 µM -0.0946056989804518 0.451906295839299 no 1855 0.462314011505426 2602 264295 SGTC_2430 5571206 200 µM -0.0952266009064865 0.451662831135578 no 1856 0.462067420761936 2607 1731771 SGTC_2095 5432005 200 µM -0.0959547322688226 0.451377343371535 no 1857 0.461778262507389 2605 783734 SGTC_3095 9117207 49.47 µM -0.0961791544661484 0.451289356356869 no 1858 0.461689143189417 2571 17015229 SGTC_979 1426-2828 121 µM -0.0974028840621459 0.450809622883671 no 1859 0.461203227235489 2672 747872 SGTC_3142 9086498 49.47 µM -0.098349778414558 0.450438465216068 no 1860 0.460827276140517 2599 25236367 SGTC_1707 st032323 6.317 µM -0.0997904677144163 0.449873836164599 no 1861 0.460255337968295 2590 3132057 YMR211W DML1 SGTC_1647 st011722 22.4 µM -0.100147471066241 0.449733936514581 no 1862 0.460113624139398 2682 2854783 SGTC_2995 9067767 71.4286 µM -0.100437334029047 0.449620351903789 no 1863 0.459998565667599 2659 11673567 SGTC_1256 0570-0116 285 µM -0.102327086927065 0.448879942027143 no 1864 0.459248527945841 2617 410638 SGTC_135 0933-0004 26.348 µM -0.102396637838919 0.448852695187507 no 1865 0.459220926131151 2672 21230617 YGL099W LSG1 SGTC_1359 1582-0056 520 nM -0.103778682423468 0.448311324044103 no 1866 0.458672492034841 2685 3661189 SGTC_1131 3454-3128 32.3 µM -0.10426105077306 0.448122394494454 no 1867 0.458481093193798 2783 710982 SGTC_3300 9124615 50.48 µM -0.104560570516676 0.448005087305376 no 1868 0.458362251655865 2735 24824903 SGTC_2788 5282734 71.43 µM -0.105184476457748 0.447760748569131 no 1869 0.458114714189648 2692 743706 SGTC_2055 5235184 200 µM -0.106021598885514 0.447432939543898 no 1870 0.45778260766771 2696 2836034 SGTC_196 k015-0023 18.111 µM -0.106194181502901 0.447365362321185 no 1871 0.457714143665868 2594 5211998 SGTC_1073 triclabendazole 3.09 µM -0.107455218357168 0.446871631576776 no 1872 0.457213925064909 2644 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3273 9137859 49.47 µM -0.108055262998423 0.44663672639629 no 1873 0.456975927626516 2591 2377234 SGTC_2805 7950783 58.44 µM -0.109256550364072 0.446166503355482 no 1874 0.456499504004919 2688 1178958 YDL195W SEC31 SGTC_1738 st035555 74 µM -0.109269533198458 0.446161421863105 no 1875 0.456494355428187 2683 5331140 SGTC_3222 9128301 49.47 µM -0.109375637753274 0.446119892781967 no 1876 0.456452278030409 2635 4911358 SGTC_2184 6075246 200 µM -0.109636846361958 0.44601765884679 no 1877 0.456348693809487 2643 2267320 SGTC_3029 9088683 49.47 µM -0.109658189879557 0.446009305406978 no 1878 0.456340230009482 2723 25236615 SGTC_783 0848-0141 92.7 µM -0.11008324425605 0.445842952343964 no 1879 0.456171678267361 2592 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2273 7815444 169.05 µM -0.110255859465061 0.445775398839985 no 1880 0.456103231406364 2601 2824616 SGTC_1031 k035-0009 16 µM -0.110439828317148 0.445703403785037 no 1881 0.456030283935624 2786 5180959 SGTC_2096 5468907 200 µM -0.111936232819799 0.445117861995968 no 1882 0.455436983743531 2717 759785 SGTC_2539 epi(13)torulosol 80 µM -0.114530629835082 0.444102961121116 no 1883 0.454408583523343 2685 6708597 SGTC_747 3448-8087 38.7 µM -0.115388267314181 0.443767542606347 no 1884 0.454068689086063 2661 5168703 SGTC_2032 5185112 25.99 µM -0.115603626972449 0.443683322641491 no 1885 0.453983344137063 2685 5718189 SGTC_235 0330-0087 5 mM -0.115805879015298 0.443604230942934 no 1886 0.453903195543873 2618 46494818 YHR062C RPP1 SGTC_1100 amiodarone 5.07 µM -0.117082053193983 0.443105228420122 no 1887 0.453397515694904 2622 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1816 st051957 91.6 µM -0.12037016048106 0.441819948597437 no 1888 0.452094963997206 2623 674121 SGTC_1370 2001-0092 44.6 µM -0.121014916720675 0.441567992866156 no 1889 0.451839610096837 2693 790957 SGTC_2676 harmalol 100 µM -0.121458186855067 0.441394786923463 no 1890 0.451664065754063 2630 5459187 A monoamine oxidase inhibitor SGTC_478 N-arachidonylglycine 10 µM -0.122401204641026 0.441026344009342 no 1891 0.451290642259995 2626 5283389 SGTC_2754 granisetron 64.02 µM -0.122470807320698 0.440999151828171 no 1892 0.451263082155258 2723 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3225 9130819 49.47 µM -0.122945332148753 0.440813773208304 no 1893 0.451075194019398 2633 4547121 SGTC_1266 0828-0227 32.9 µM -0.123576812289595 0.440567098297481 no 1894 0.450825176423702 2733 3913820 SGTC_347 4534-1311 26.2 µM -0.123738976396317 0.44050375589556 no 1895 0.450760975046947 2604 2862016 SGTC_140 0062-0056 502.533 µM -0.12374960204162 0.440499605499436 no 1896 0.450756768359158 2607 3758964 SGTC_1296 1068-0102 11.9 µM -0.124750816889123 0.440108558572541 no 1897 0.45036041277127 2729 767053 SGTC_205 1486-1330 71.903 µM -0.12497617736242 0.440020547022754 no 1898 0.450271205081683 2617 4118834 SGTC_1364 1653-0028 37.6 µM -0.125263017712065 0.439908529608429 no 1899 0.450157664559761 2703 5718652 SGTC_987 1497-1013 404 µM -0.127684591758602 0.438963044704772 no 1900 0.449199292134899 2627 1676435 SGTC_1940 st075990 51.1 µM -0.127742718613503 0.43894035378011 no 1901 0.449176291223217 2890 1084979 SGTC_3148 9097893 49.47 µM -0.128033137331676 0.43882698631064 no 1902 0.449061374520735 2662 17174100 SGTC_798 1287-0182 476 µM -0.12811034920523 0.438796846829139 no 1903 0.449030823028547 2626 1649755 SGTC_2038 4100038 30.985 µM -0.128385773295583 0.438689338545784 no 1904 0.448921844624172 2724 3596803 SGTC_2058 5236698 133 µM -0.128660051920421 0.438582281875569 no 1905 0.448813323281221 2662 766665 SGTC_1534 6-azauridine 81.6 µM -0.128765349301347 0.438541183304009 no 1906 0.448771662235659 2615 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_10 0279-0212 42.575 µM -0.12924439583635 0.438354215247179 no 1907 0.448582133989089 2660 39851 YBR002C RER2 SGTC_490 phenamil 164 µM -0.129791694074669 0.438140625932906 no 1908 0.448365617247712 2741 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_963 1269-2853 151 µM -0.130505682186417 0.437862011109881 no 1909 0.448083179428496 2670 3668223 SGTC_1766 st045414 44.774 µM -0.13151927960487 0.437466534677886 no 1910 0.44768226806198 2638 253960 SGTC_2227 7312221 64.1025 µM -0.131523063174208 0.437465058555207 no 1911 0.447680771634794 2645 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2214 7179297 48.276 µM -0.132132609831174 0.437227261251029 no 1912 0.447439701560023 2634 769744 SGTC_3136 9095672 49.47 µM -0.132555661171575 0.437062233119091 no 1913 0.447272400069346 2585 17217380 SGTC_790 1575-0012 79.1 µM -0.132706263664456 0.437003487221941 no 1914 0.447212844498052 2645 378741 YLR208W SEC13 SGTC_852 0418-0143 439 µM -0.133903275130208 0.43653661541773 no 1915 0.446739530216141 2668 5369229 SGTC_998 3996-0085 177 µM -0.134822760707135 0.43617804735801 no 1916 0.446376004849106 2705 715391 SGTC_2240 6690706 185.951 µM -0.135047141255809 0.43609055453528 no 1917 0.446287301181877 2623 805876 SGTC_664 1222-0054 14.9 µM -0.136192120765085 0.435644140870565 no 1918 0.445834701925128 2681 6813991 SGTC_184 1494-0393 24.714 µM -0.136211550309089 0.435636566232197 no 1919 0.445827022222767 2634 3090647 SGTC_2024 5144227 134 µM -0.136847840096611 0.435388520719573 no 1920 0.445575534198362 2784 3475211 SGTC_537 1334-0398 209 µM -0.13934162323061 0.434416612575121 no 1921 0.444590100051281 2645 5846986 SGTC_1693 xanthone 101.9 µM -0.13942391428639 0.434384547803964 no 1922 0.444557588023322 2698 7020 An insecticide. SGTC_2004 4023728 41.89 µM -0.140529294407599 0.433953877541528 no 1923 0.444120904273762 2720 360084 YDR527W RBA50 SGTC_3215 9129942 49.47 µM -0.144269469593518 0.432497241640138 no 1924 0.442643842900654 2705 17682944 SGTC_419 nsc-638432 893 µM -0.144895654901513 0.432253458714111 no 1925 0.442396628559419 2722 368090 SGTC_1015 4130-4525 82 µM -0.146598112369169 0.431590798231436 no 1926 0.44172462184849 2691 1363237 SGTC_3228 9131799 49.47 µM -0.147281743371207 0.431324757387709 no 1927 0.441454821002904 2713 17015818 SGTC_1223 0764-0573 147 µM -0.147743468018295 0.431145090915525 no 1928 0.441272612767225 2676 1609797 SGTC_842 0271-0008 11.1 µM -0.148565454658417 0.430825274439533 no 1929 0.440948266812031 2775 1221709 SGTC_1929 genistein trimethyl ether 50.5 µM -0.149083058760763 0.430623909609669 no 1930 0.440744046822053 2687 136420 SGTC_2176 5809774 33.9695 µM -0.149283042628348 0.430546114208916 no 1931 0.440665147678332 2790 2870539 SGTC_143 4032-1194 15.74 µM -0.149489337561547 0.430465866575149 no 1932 0.440583761113549 2625 1806963 SGTC_2380 9035439 200 µM -0.149552606331849 0.43044125593463 no 1933 0.440558801100823 2802 6462575 SGTC_1741 st038134 10.228 µM -0.150414806119193 0.430105899602151 no 1934 0.440218680284669 2836 1272587 SGTC_1974 st069448 26.9 µM -0.151307100299355 0.42975889101162 no 1935 0.439866734269665 2773 6323587 YNR016C ACC1 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.152002880735016 0.429488343234645 no 1936 0.439592331778727 2680 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_944 3370-0224 231 µM -0.152609974825494 0.42925230736886 no 1937 0.439352929187741 2713 4580514 SGTC_1389 3405-0187 19 µM -0.153895401351601 0.428752622014764 no 1938 0.438846105049752 2741 799890 SGTC_180 1486-1293 102.781 µM -0.154758540017254 0.42841715713871 no 1939 0.438505838804189 2712 4140536 SGTC_906 1165-0455 526 µM -0.155849224066859 0.427993329153456 no 1940 0.438075934722757 2672 3252859 SGTC_2270 7924575 90.91 µM -0.157073048908688 0.427517863008819 no 1941 0.437593638877765 2906 1262135 SGTC_1786 berberine 21.6 µM -0.157186742311245 0.427473697507508 no 1942 0.437548838259571 2678 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1361 1608-0041 5.61 µM -0.158134580071584 0.427105534523577 no 1943 0.437175376230489 2694 X1361 SGTC_1626 st003712 1.76 µM -0.158804618781276 0.426845313654048 no 1944 0.436911404866384 2837 24207035 SGTC_827 3253-0474 693 µM -0.159283121318419 0.426659498576095 no 1945 0.436722909109947 2743 5402065 SGTC_2037 5169046 200 µM -0.160158269982234 0.426319697543376 no 1946 0.436378200359526 2803 5718022 SGTC_684 1140-0066 328 µM -0.160391601110687 0.426229109407616 no 1947 0.436286302656576 2746 6813534 SGTC_3305 9127027 53.8275 µM -0.161642483992063 0.425743534948935 no 1948 0.435793699917865 2744 41905295 SGTC_2934 9036370 36.88 µM -0.161856019111054 0.425660654965367 no 1949 0.435709618855164 2795 6462800 SGTC_426 0988-0037 14.6 µM -0.16219428911431 0.425529368005812 no 1950 0.435576428441016 2666 5383008 SGTC_1134 3477-0009 42.5 µM -0.16225208232535 0.425506938539167 no 1951 0.435553673675461 2951 3973534 SGTC_1173 0443-0020 122 µM -0.16314387218623 0.425160866709279 no 1952 0.435202578745901 2709 5331295 SGTC_80 0159-0065 512.242 µM -0.163210049919759 0.425135187786787 no 1953 0.435176526807893 2648 1548079 SGTC_1474 0330-0125 5.35 µM -0.165376350266348 0.424294775027362 no 1954 0.434323883557361 2733 X1474 SGTC_505 gw-5074 63.9 µM -0.165563775597905 0.424222079788531 no 1955 0.434250128333191 2811 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1960 st011366 51.8 µM -0.165607921465861 0.42420495764129 no 1956 0.434232756476561 2685 3972846 SGTC_1627 st003713 25.6 µM -0.16695159445717 0.423683877415469 no 1957 0.433704068143312 2782 16195070 YER133W GLC7 SGTC_107 0358-0022 2.6945 µM -0.167843955738327 0.42333789083083 no 1958 0.433353020657583 2769 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1718 roemerine 11.9335 µM -0.16829180365317 0.42316427336103 no 1959 0.433176860819899 2800 235224 An aporphine alkaloid with mutagenic activity. SGTC_687 k029-0044 34.9 µM -0.17086497380672 0.422167021079594 no 1960 0.432164969225055 2829 5829338 SGTC_2199 6590217 200 µM -0.171385140092001 0.421965486956631 no 1961 0.43196046919895 2758 703109 SGTC_2458 5808907 16.39 µM -0.174364992418626 0.420811363198569 no 1962 0.430789312422638 2738 2731747 SGTC_379 3970-0972 5.9 µM -0.174829156216206 0.420631649346854 no 1963 0.430606938902783 2780 2898042 YBL034C STU1 SGTC_245 methotrexate 289.6 µM -0.175044541520188 0.420548262585746 no 1964 0.430522317387662 2779 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_132 0417-1715 25.805 µM -0.175764821920201 0.420269430807283 no 1965 0.430239353686402 2769 6769098 SGTC_3108 9121785 49.47 µM -0.176592725023064 0.419948986030817 no 1966 0.429914154433273 2646 17140271 SGTC_2447 5741742 33.78 µM -0.176728383071621 0.41989648383764 no 1967 0.429860872657167 2804 1776504 SGTC_1921 5740136 50 µM -0.1769191551476 0.419822653900878 no 1968 0.429785946164238 2801 1774243 SGTC_620 0109-0052 432 µM -0.177545931608905 0.419580107532636 no 1969 0.429539795028612 2799 493037 SGTC_1040 k898-0338 155 µM -0.177552862161136 0.419577425757794 no 1970 0.429537073376556 2895 20969351 SGTC_2440 5628896 157.78 µM -0.177834699065458 0.419468372228808 no 1971 0.429426397879038 2747 5522048 SGTC_2823 7987624 58.44 µM -0.178070721980574 0.419377050651261 no 1972 0.429333717500935 2894 2239440 SGTC_3244 9134489 49.47 µM -0.17966804963062 0.418759129787048 no 1973 0.42870658896041 2803 16584271 SGTC_2204 7233102 200 µM -0.180561009111421 0.418413778619956 no 1974 0.428356081490497 2738 2172480 SGTC_1248 0469-0687 58.6 µM -0.181117205296909 0.418198702077459 no 1975 0.428137790029564 2829 4017482 SGTC_2183 6420625 130.508 µM -0.181857502326623 0.417912473186771 no 1976 0.427847278253678 2723 2897619 SGTC_1799 st045822 46.1415 µM -0.183063870461709 0.417446135496386 no 1977 0.427373951935618 2821 3674992 SGTC_49 0717-0965 32.132 µM -0.184186541762312 0.41701225620465 no 1978 0.426933558489892 3018 5889349 YGL099W LSG1 SGTC_3316 9136639 10.545 µM -0.18669243797491 0.416044166606182 no 1979 0.425950892740703 2826 4903665 SGTC_369 0957-0393 4.5 µM -0.186893441122393 0.41596653610788 no 1980 0.425872090909824 2801 6997992 SGTC_856 0433-0016 11.3 µM -0.189084485115963 0.415120534606227 no 1981 0.425013300613078 2817 3911780 SGTC_3303 9125618 40.5795 µM -0.189314417022001 0.415031776502793 no 1982 0.424923198244471 2842 22695467 SGTC_1637 st007924 17.4 µM -0.189545672720165 0.414942511764547 no 1983 0.424832581083437 2721 683336 SGTC_522 1273-0010 11.6 µM -0.190461745904211 0.414588950556053 no 1984 0.424473658404946 2978 5705015 SGTC_996 3970-0799 1.8 µM -0.190478850940317 0.414582349472878 no 1985 0.424466957149232 2813 6615648 YGL040C HEM2 SGTC_1088 bifonazole 369 nM -0.190515004140723 0.414568397504366 no 1986 0.424452793448532 2720 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_810 3825-7150 143 µM -0.191271621105823 0.414276434388665 no 1987 0.424156396840292 2932 22330411 YGL099W LSG1 SGTC_2089 5281248 129.67 µM -0.192744510264002 0.413708212367124 no 1988 0.423579531421855 2759 2737878 SGTC_2575 plumbagin 510 nM -0.193744901477724 0.413322377018625 no 1989 0.423187815814646 2721 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3141 9094609 49.47 µM -0.194569703976699 0.41300432643859 no 1990 0.422864911231001 2729 25236309 YDL196W YDL196W SGTC_2651 TUB2.036 5 µM -0.195712626822461 0.412563700465132 no 1991 0.422417550382084 2836 15992207 YFL037W TUB2 SGTC_1064 honokiol 6.76 µM -0.196120073848872 0.412406645829131 no 1992 0.422258092347799 2836 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1304 1165-0502 251 µM -0.196234030178835 0.412362722701458 no 1993 0.42221349679893 2795 767425 SGTC_454 lyso-paf C-16 6.67 µM -0.196716594197672 0.412176736244813 no 1994 0.422024661768917 2819 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_69 0096-0274 206.684 µM -0.197092692796732 0.412031796620691 no 1995 0.421877500789986 3040 6741392 SGTC_1496 4469-0713 57.4 µM -0.197125681317618 0.41201908418661 no 1996 0.421864593463433 2866 746691 SGTC_582 0987-0078 156 µM -0.19817946719856 0.411613046623166 no 1997 0.421452325839249 2774 1625765 SGTC_1061 3448-9325 110 µM -0.198271689180712 0.411577516777328 no 1998 0.421416250363339 2712 723482 SGTC_2464 5717415 7.67 µM -0.199690939315102 0.411030821846749 no 1999 0.420861150217056 2761 5285744 SGTC_760 0568-0725 82.9 µM -0.200771772922108 0.410614600724668 no 2000 0.420438517718867 2920 3916171 SGTC_259 usnic acid 108.925 µM -0.200846886279633 0.410585678854455 no 2001 0.420409149952839 2944 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1466 k213-0079 57.5 µM -0.202495865056862 0.409950873933467 no 2002 0.419764545331534 2754 3657981 SGTC_216 k038-0035 28.382 µM -0.20258376954129 0.409917040083508 no 2003 0.419730188492462 2783 4444231 YPR107C YTH1 SGTC_2 0422-0095 29 µM -0.203592248792643 0.409528931188731 no 2004 0.419336075425606 2740 6790840 SGTC_3033 9090887 49.47 µM -0.204908514309116 0.409022505481205 no 2005 0.418821801454994 2778 19325384 SGTC_3313 9133968 57.047 µM -0.204977190506048 0.408996086863293 no 2006 0.418794972992937 2737 1494643 SGTC_1391 3442-0225 151 µM -0.206373183131147 0.408459160937004 no 2007 0.418249708356519 2775 5227075 SGTC_308 4092-1169 104 µM -0.206427892383379 0.408438122185848 no 2008 0.41822834250945 2794 2268590 YDL196W YDL196W SGTC_1409 3909-8004 61.9 µM -0.206689478833905 0.408337531291157 no 2009 0.418126187328156 2809 2119279 SGTC_2297 7971671 152.32 µM -0.20837180412442 0.407690751686613 no 2010 0.417469335091338 2932 909016 SGTC_633 0437-0093 97.7 µM -0.208450819740977 0.407660379850152 no 2011 0.417438489638614 2766 2831118 SGTC_1916 st067606 49.2 µM -0.210686641312536 0.406801210716581 no 2012 0.41656589966159 2883 19590279 SGTC_2916 7875993 68.79 µM -0.211313408822653 0.406560440253995 no 2013 0.416321360217732 2790 1299250 SGTC_1830 st055982 50.3 µM -0.212839483616429 0.405974352034102 no 2014 0.415726082893441 2774 455313 An antimicrobial agent. SGTC_1696 st025591 34.7925 µM -0.213418925564077 0.405751872767994 no 2015 0.415500110032968 2794 2787147 SGTC_1564 D-Arginine 115 µM -0.213522236781436 0.405712209170276 no 2016 0.415459823284925 2816 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_977 1348-1378 135 µM -0.213527410653608 0.405710222824936 no 2017 0.41545780572985 2768 X977 SGTC_3068 9116768 49.47 µM -0.213569174312828 0.405694189071647 no 2018 0.415441520043323 2881 41904888 SGTC_2521 angolensin 13.4 µM -0.21363895669282 0.40566739882528 no 2019 0.415414308815916 2930 821428 A flavenoid. SGTC_1115 galangin 695.678 nM -0.213837072453096 0.405591342348399 no 2020 0.415337056955117 2803 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3177 9107506 49.47 µM -0.214574590384493 0.405308241175342 no 2021 0.415049503211311 2900 8897194 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.215416402428034 0.404985166557637 no 2022 0.414721341447218 2998 165506 SGTC_1087 pterostilbene 9.05 µM -0.215577461295055 0.404923361994243 no 2023 0.414658562992694 2919 5281727 Similar to reservatol, lowers cholesterol. SGTC_2452 5863136 48.41 µM -0.216180238710555 0.404692073869671 no 2024 0.414423628290277 2754 2184096 SGTC_3333 9141820 12.094 µM -0.217439109914077 0.404209147383052 no 2025 0.413933077454372 2820 1939433 SGTC_2486 5283202 22.39 µM -0.217831517533457 0.404058642297611 no 2026 0.413780193366192 2852 1377751 SGTC_2783 7738165 71.43 µM -0.219007587813903 0.403607654246931 no 2027 0.41332206851383 2863 17201110 SGTC_105 0111-0055 734.78 µM -0.219041501107777 0.403594651403066 no 2028 0.413308859721699 2869 5179370 SGTC_1553 gossypol 38.6 µM -0.219891154577582 0.403268916874938 no 2029 0.412977962675801 2758 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1519 esterone 74 µM -0.221424820075586 0.402681120361474 no 2030 0.412380834195956 2790 698 A steroid. SGTC_452 diindolylmethane 8 µM -0.221445800382708 0.402673080917754 no 2031 0.412372666973274 2903 3071 Inhibits expression of several cancer promoting factors. SGTC_2606 farnesol 9.78 µM -0.221849475392272 0.402518404711778 no 2032 0.412215531590394 2972 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2929 9013348 24.6 µM -0.222509442142563 0.402265558043151 no 2033 0.411958661865589 2897 2995952 SGTC_531 3788-1495 174 µM -0.223382811223516 0.401931015479609 no 2034 0.411618790507134 2758 2896655 SGTC_1944 st076371 56.9 µM -0.223940856691223 0.401717294698927 no 2035 0.411401661954 2804 24208455 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.224156767828785 0.401634612729583 no 2036 0.411317660891072 2899 5379071 SGTC_3315 9136395 68.55 µM -0.224774099737291 0.401398233213588 no 2037 0.411077507966838 2847 16876844 SGTC_636 0kpi-0074 126 µM -0.224777097550852 0.401397085423544 no 2038 0.411076341846088 2886 616434 SGTC_1289 0976-0073 69.1 µM -0.225157431631219 0.401251471640973 no 2039 0.410928401910413 2911 3391136 SGTC_1295 1013-0063 9.78 µM -0.226639810874968 0.400684062592934 no 2040 0.410351916541947 2905 6826038 SGTC_361 000s-0510 1.45 µM -0.227646022239297 0.400299035203305 no 2041 0.4099607192926 2895 660 SGTC_3249 9135183 49.47 µM -0.227737205135103 0.400264148794578 no 2042 0.409925273411243 2981 4902779 SGTC_3132 9126706 49.47 µM -0.228295614701474 0.400050519687785 no 2043 0.409708216757649 3019 850858 SGTC_1255 0566-0045 221 µM -0.22914869643816 0.399724216478334 no 2044 0.409376672969667 2964 2788469 SGTC_967 1306-0166 352 µM -0.229291484004213 0.399669607161581 no 2045 0.409321185983223 2951 4437607 SGTC_2919 7978188 46.38 µM -0.229365326226909 0.399641366863646 no 2046 0.409292491743413 2964 2980291 SGTC_858 0438-0351 2.77 µM -0.229492814659708 0.399592611288004 no 2047 0.409242952346299 2839 2799119 SGTC_1679 SEC14.276 6.7 µM -0.230391173045918 0.399249095291078 no 2048 0.408893909788412 2962 1005053 YMR079W SEC14 SGTC_1967 st070177 51.4 µM -0.230525535648419 0.399197724161214 no 2049 0.408841711585166 2984 5729214 SGTC_1938 st074717 56.4 µM -0.230769096253461 0.399104607585342 no 2050 0.408747095435651 2771 17250979 SGTC_2800 7887935 81.82 µM -0.230988867972221 0.399020590755628 no 2051 0.408661725134525 2994 2961002 SGTC_1902 st060212 70.5 µM -0.232463661872316 0.398456910994439 no 2052 0.408088953908568 2818 688944 SGTC_533 1222-0222 6.71 µM -0.232583504456938 0.398411115347742 no 2053 0.408042418804933 3008 3982874 SGTC_757 1066-0008 322 µM -0.233625350851157 0.39801305186146 no 2054 0.407637922588001 2982 6842497 SGTC_2252 omeprazole 400 µM -0.235789654124713 0.397186465325739 no 2055 0.406797948325446 2878 4594 A proton pump inhibitor. SGTC_2182 6325192 200 µM -0.236131935654995 0.397055784000196 no 2056 0.406665146723447 2815 736248 SGTC_2864 9034755 47.6 µM -0.236497011010703 0.396916412847553 no 2057 0.406523513188398 2795 4930451 SGTC_634 1611-4317 11.2 µM -0.236805424862033 0.396798683046551 no 2058 0.40640387140766 2811 2843522 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.237591396968838 0.396498699062148 no 2059 0.40609901185005 2809 3256 An antibiotic and ribosome inhibitor. SGTC_2986 9022445 71.43 µM -0.23792070643296 0.396373028876207 no 2060 0.40597129759046 3037 6459286 SGTC_405 ebelactone b 50 µM -0.238890351381695 0.3960030581626 no 2061 0.405595303734021 2820 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_357 1325-0123 420 µM -0.240197614361202 0.395504416661376 no 2062 0.405088531509323 2959 1098503 SGTC_596 1155-0152 116 µM -0.240435413689076 0.395413729007769 no 2063 0.40499636354525 2852 280313 SGTC_1572 epiandrosterone 68.9 µM -0.240521512507758 0.395380895576742 no 2064 0.404962994048494 2810 441302 A steroid. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.240856189279282 0.395253275019757 no 2065 0.40483328924762 2857 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2125 5246583 200 µM -0.244707326193703 0.393785552627239 no 2066 0.403341527501475 2934 835267 SGTC_2360 9040895 200 µM -0.245225625616276 0.393588136079279 no 2067 0.403140867833219 2898 4914414 SGTC_1613 st002381 52.1 µM -0.245600148042745 0.393445500181212 no 2068 0.402995887311022 2846 551167 SGTC_1103 duloxetine 36.1 µM -0.245776862383402 0.393378203945303 no 2069 0.402927484454962 3005 60835 A selective serotonin reuptake inhibitor. SGTC_685 1278-0033 54.9 µM -0.247324231256882 0.392789072245697 no 2070 0.402328653675236 2979 3590572 SGTC_2938 9059746 27.26 µM -0.247973929756891 0.392541784825786 no 2071 0.402077288986982 2967 6471769 SGTC_701 4424-0219 185 µM -0.248542971494092 0.392325232510599 no 2072 0.401857163207419 3011 2911779 SGTC_1007 4101-0031 70 µM -0.250546815625289 0.391562923196712 no 2073 0.40108225261096 3022 1146276 SGTC_126 0417-1624 672.48 µM -0.250607212493952 0.391539953258278 no 2074 0.401058902439971 2930 41912 YDL195W SEC31 SGTC_483 fpl-64176 144 µM -0.250911696118427 0.391424158808112 no 2075 0.400941190715968 2849 3423 SGTC_950 1165-0508 94.1 µM -0.251095843965206 0.391354132456738 no 2076 0.400870004516691 2930 6148369 SGTC_195 4234-0266 16.654 µM -0.251840835825914 0.391070868543219 no 2077 0.400582045958318 2879 2303354 SGTC_1290 0986-0249 10.2 µM -0.252911258387947 0.390663969188023 no 2078 0.400168394655664 2905 53329 SGTC_2194 5927483 104.545 µM -0.253306397431185 0.390513795346047 no 2079 0.400015726426135 2841 760979 SGTC_2608 thymoquinone 42.66 µM -0.254119033597138 0.3902050017575 no 2080 0.39970179961943 2859 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2515 chrysin 20.77 µM -0.25477183873653 0.389956992511898 no 2081 0.399449663553324 2947 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_41 0478-0632 82.643 µM -0.255134762070475 0.389819132536945 no 2082 0.399309508059047 2863 3750424 SGTC_2900 5328528 85.29 µM -0.25521978020607 0.389786839570397 no 2083 0.399276677218299 2853 795359 SGTC_823 0417-1665 178 µM -0.255291284761172 0.389759680140075 no 2084 0.399249065371055 2966 3429856 SGTC_2027 5150920 200 µM -0.255752664435639 0.389584448180584 no 2085 0.399070913390088 2928 786715 SGTC_745 0469-0705 296 µM -0.255809154293644 0.389562994879108 no 2086 0.399049102472579 3060 3486736 SGTC_2266 7929956 200 µM -0.256177440646111 0.389423138057143 no 2087 0.398906913645185 2823 2967153 SGTC_141 0443-0274 32.331 µM -0.256310111554713 0.389372759758714 no 2088 0.398855695046573 2986 1627241 SGTC_192 3455-0609 60.9 µM -0.25632058182011 0.389368784029142 no 2089 0.398851652996282 2994 3769639 SGTC_2983 9022671 12.99 µM -0.256602004185891 0.389261927732815 no 2090 0.398743013841019 3053 6405161 SGTC_2680 butyl paraben 22.24 µM -0.257591892268455 0.388886133018754 no 2091 0.398360943818399 2847 7184 An antifungal and steroid mimetic. SGTC_447 ml7 120 µM -0.260667402076066 0.387719230937958 no 2092 0.39717450326787 2924 4216 Selective myosin light chain kinase inhibitor. SGTC_1142 3253-1408 9.78 µM -0.260927791832856 0.387620480906147 no 2093 0.397074096125488 2859 256655 SGTC_926 2268-1401 59.4 µM -0.261175368233349 0.387526596944015 no 2094 0.396978636181585 2841 2931578 SGTC_2628 lathosterol 100 µM -0.262043646386631 0.387197387389656 no 2095 0.396643896290139 3020 6710616 SGTC_303 1348-1668 34.2 µM -0.262432404099611 0.387050015330878 no 2096 0.396494046502928 2890 5380509 SGTC_2459 5811157 9.22 µM -0.262510112288246 0.387020559305685 no 2097 0.396464095089226 2855 2870684 YBR192W RIM2 SGTC_2742 clothiapine 36.27 µM -0.263045951122207 0.386817462239109 no 2098 0.396257580978757 2932 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2913 7966556 36.57 µM -0.263114198905256 0.386791596751088 no 2099 0.396231280139373 2980 2976516 SGTC_2726 cimetidine 79.27 µM -0.263196721347261 0.386760321927134 no 2100 0.396199478865462 2868 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_373 0844-0104 25.9 µM -0.267941826313004 0.384963237967996 no 2101 0.394372048828672 3010 5375804 SGTC_2157 5649910 96.377 µM -0.268170809602559 0.384876578680702 no 2102 0.394283921437072 2881 2858091 SGTC_1728 st035614 33.7865 µM -0.26943879794294 0.384396809585388 no 2103 0.393796016623315 2975 15945546 SGTC_1138 3761-0006 1.03 µM -0.270167492272613 0.384121173367676 no 2104 0.393515700235721 2864 12061087 SGTC_1241 0364-0022 50.8 µM -0.271685338581848 0.383547220492313 no 2105 0.392931987760975 2929 4563895 SGTC_3324 9138759 60.749 µM -0.271760009660765 0.383518991224565 no 2106 0.392903277984318 3013 45595710 SGTC_1094 duloxetine 25.4 µM -0.271766265863439 0.38351662610641 no 2107 0.392900872605834 2870 60834 A selective serotonin reuptake inhibitor. SGTC_84 0443-0269 128.823 µM -0.271881594288162 0.383473027696851 no 2108 0.392856531982281 2890 6150058 SGTC_1617 st002906 78 µM -0.272111911982721 0.383385963506872 no 2109 0.392767985292202 2859 5150859 SGTC_1663 st014140 55.4 µM -0.273355870969626 0.382915826754509 no 2110 0.392289835611334 2921 4207120 SGTC_484 loperamide 105 µM -0.273704043658815 0.382784270654556 no 2111 0.392156034997773 2853 3955 An opioid-receptor agonist. SGTC_575 k072-0246 11.9 µM -0.275317305786626 0.382174880673913 no 2112 0.391536234972785 2877 6796779 SGTC_731 3966-0296 387 µM -0.27594143380291 0.381939202156537 no 2113 0.391296524656536 2897 660956 SGTC_1546 5-methoxyflavanone 78.7 µM -0.276965497479767 0.381552597761187 no 2114 0.39090329958258 2964 147795 SGTC_914 3820-6779 408 µM -0.277294397976711 0.381428456331207 no 2115 0.390777030371596 2850 2893481 SGTC_2563 tomatine 8.54 µM -0.280780586908353 0.380113368370817 no 2116 0.389439347145845 3046 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_224 benfluorex 43.875 µM -0.283825092113868 0.378966027960691 no 2117 0.388272212109904 3001 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2052 5265182 7.135 µM -0.284273026074512 0.378797310990887 no 2118 0.388100577932302 3060 1239884 SGTC_698 k064-0052 127 µM -0.285057622550786 0.378501843766846 no 2119 0.387799997971095 2913 5088751 SGTC_313 3474-0040 5.03 µM -0.28563128332505 0.378285856686381 no 2120 0.387580270291015 2893 1043375 YIL048W NEO1 SGTC_2062 5245942 200 µM -0.285689770307542 0.37826383808516 no 2121 0.387557870207071 2885 1376160 SGTC_1982 st072467 71.9 µM -0.286789339552928 0.37784995677529 no 2122 0.387136813017726 2864 3163533 SGTC_3053 9095903 49.47 µM -0.28717782112671 0.377703764580565 no 2123 0.386988083786468 2964 17174018 SGTC_2000 st075254 36.4 µM -0.287516319236286 0.37757639628982 no 2124 0.3868585041299 2913 17234175 SGTC_449 xestospongin c 11.1929 µM -0.288934593652051 0.377042880324192 no 2125 0.386315715139624 3031 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1209 2323-2347 50.3 µM -0.290387181976381 0.37649669963882 no 2126 0.385760024371741 2988 5412760 SGTC_2763 lisinopril 49.32 µM -0.290459697100478 0.37646944004752 no 2127 0.385732289688631 2927 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2341 7987486 176.74 µM -0.291953244255722 0.375908129056497 no 2128 0.38516118645472 3084 1258686 SGTC_404 fumagillin 50 µM -0.292065074531224 0.375866111092951 no 2129 0.385118434748064 2975 12015870 A methionine aminopeptidase binder. SGTC_2682 pyrogallin 40.03 µM -0.292207049442909 0.375812769012679 no 2130 0.385064161030316 2956 822798 An ATP competetive kinase inhibitor. SGTC_2155 5570423 76 µM -0.292327184153213 0.375767634473647 no 2131 0.385018238073916 2940 797402 SGTC_1279 0874-0590 65.2 µM -0.292996148945814 0.375516335901587 no 2132 0.384762547643628 2975 3523074 SGTC_77 0828-0286 12.516 µM -0.293496126494372 0.375328552355719 no 2133 0.384571479907773 2904 745345 SGTC_1495 4469-0029 237 µM -0.294123355307979 0.37509301705267 no 2134 0.384331822418035 2910 793680 SGTC_2469 5655019 90.81 µM -0.295154805130759 0.374705791041283 no 2135 0.383937812524711 3049 2788239 SGTC_248 streptozotocin 5.23457 mM -0.295999774570032 0.374388667429185 no 2136 0.383615126776889 3025 5300 DNA alkylating agent. SGTC_2160 5660466 132.927 µM -0.297143613372896 0.373959511198475 no 2137 0.383178434276198 2984 2859134 SGTC_3153 9100258 49.47 µM -0.297304993437408 0.37389897566395 no 2138 0.38311683485005 2945 25236848 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.297326651575692 0.373890851681681 no 2139 0.383108568075592 2990 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1332 1480-0653 17.5 µM -0.298156236988153 0.373579715834414 no 2140 0.382791960672659 3066 5749438 SGTC_2116 5511452 16.8835 µM -0.298176693344416 0.373572044721942 no 2141 0.382784154588108 3046 870744 SGTC_1620 st003704 16.5 µM -0.298230007806086 0.373552052089292 no 2142 0.382763810172279 2945 2834414 SGTC_3164 9100705 49.47 µM -0.298817051580793 0.373331936386772 no 2143 0.382539819883897 3074 17174235 SGTC_392 N-ethylmaleimide 8.33 µM -0.299267893761302 0.37316291836927 no 2144 0.382367824849818 2973 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2427 5545055 42.75 µM -0.301350314252386 0.372382548640892 no 2145 0.381573688860955 2955 5372858 SGTC_2121 5257820 149.641 µM -0.301840792430836 0.372198822111655 no 2146 0.38138671621863 3095 791256 SGTC_1029 k015-0030 64.7 µM -0.302134280552068 0.372088899316179 no 2147 0.381274850367787 3046 2208316 SGTC_1505 k297-0037 20.6 µM -0.302243724981577 0.372047910758813 no 2148 0.381233137098062 2954 4089396 SGTC_1486 3970-0793 4.53 µM -0.302698683705796 0.371877537534297 no 2149 0.381059750505054 3031 2844330 SGTC_1017 4239-0030 168 µM -0.303598668371438 0.37154058464345 no 2150 0.380716833105252 2947 1149593 SGTC_865 0488-0499 301 µM -0.304417050428182 0.371234269063053 no 2151 0.380405089727619 3107 9634651 SGTC_516 3992-2719 87.3 µM -0.304672211992116 0.371138780261445 no 2152 0.380307907808515 2874 5350887 YDR037W KRS1 SGTC_2289 7946404 165.07 µM -0.304673150725178 0.371138428975155 no 2153 0.380307550292591 2918 1246120 YPR165W RHO1 SGTC_606 k015-0008 38.6 µM -0.304989161931103 0.371020179518763 no 2154 0.380187203426873 3088 1970475 SGTC_459 nigericin 15.3 µM -0.305076047792634 0.370987669495869 no 2155 0.380154116629153 3072 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2349 9023730 187.07 µM -0.30897253828731 0.369530672135719 no 2156 0.378671208353944 3100 4126287 SGTC_716 1683-5115 658 µM -0.309120325832946 0.3694754473056 no 2157 0.378614999046427 2929 723597 SGTC_891 0929-0073 133 µM -0.309205740623655 0.369443530977174 no 2158 0.378582513675747 3078 5603632 SGTC_95 0471-0001 561.058 µM -0.309420067517973 0.369363448954989 no 2159 0.378501003601597 2958 4015405 SGTC_486 niguldipine 82 µM -0.310466070468479 0.368972697308489 no 2160 0.37810327871047 2952 1236 A calcium channel blocker. SGTC_559 1550-0661 158 µM -0.311220916923223 0.368690796046998 no 2161 0.377816341341911 3022 5830875 SGTC_612 0302-0167 22.4 µM -0.312981525603619 0.368033562517781 no 2162 0.377147348986322 3024 235821 SGTC_3321 9137793 26.8275 µM -0.313498441683149 0.367840671476813 no 2163 0.376951002212052 2994 4904192 SGTC_2046 4110841 106 µM -0.314175642117794 0.367588019581394 no 2164 0.376693820754255 3123 44119630 YMR134W ERG29 SGTC_3272 9137413 49.47 µM -0.315685856756754 0.367024790845801 no 2165 0.376120481414482 2928 17614870 SGTC_3084 9116877 49.47 µM -0.316550092449315 0.366702606089337 no 2166 0.375792505007531 3040 27241325 SGTC_1705 st027868 56.3335 µM -0.317065647744483 0.36651045314954 no 2167 0.375596895100379 3038 292948 SGTC_383 2324-0395 7.37 µM -0.317634201218571 0.366298586017901 no 2168 0.375381213911944 3099 3146421 SGTC_1959 st077091 55.8 µM -0.318165323746763 0.366100704053888 no 2169 0.375179767364846 2914 821356 YKL052C ASK1 SGTC_247 mechlorethamine 29.705 µM -0.318289515803764 0.36605443856944 no 2170 0.375132668149807 2959 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_708 3448-5400 146 µM -0.318607438595343 0.365936011110406 no 2171 0.375012106009619 3070 3462195 SGTC_1493 4348-0038 111 µM -0.319464501707625 0.365616815471323 no 2172 0.374687152857916 3024 800424 SGTC_583 1488-1091 88.9 µM -0.320625489917121 0.365184577537048 no 2173 0.374247109244725 3052 4303273 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.32098357382395 0.365051296796387 no 2174 0.374111419495539 2918 688667 SGTC_628 1636-0253 16 µM -0.321669480288638 0.36479604428117 no 2175 0.373851550575472 3051 4456143 SGTC_47 0149-0135 24.25 µM -0.321877040876136 0.364718814704793 no 2176 0.373772923529659 2956 5239155 SGTC_2085 5307070 144.047 µM -0.322673513927334 0.364422512322849 no 2177 0.373471256438964 2935 2840351 SGTC_2591 skatole 100 µM -0.322702086495449 0.36441188431458 no 2178 0.373460435913252 3090 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_564 3555-0129 330 µM -0.323037367636056 0.364287179103156 no 2179 0.373333471296697 2976 563260 SGTC_874 0599-0792 117 µM -0.325020137460994 0.363549997372047 no 2180 0.372582915457048 3142 765305 SGTC_2076 5212012 200 µM -0.32606613819888 0.363161303949609 no 2181 0.372187157973327 2958 604802 SGTC_569 4130-2812 160 µM -0.32650310492037 0.362998969002364 no 2182 0.372021870259996 2989 743552 SGTC_2462 5162487 171.77 µM -0.329499115885918 0.361886602799772 no 2183 0.370889231048898 2960 2259986 SGTC_176 1486-1328 72.834 µM -0.330360732223115 0.36156691522997 no 2184 0.370563704295828 3044 22310231 SGTC_2507 purpurin 79.67 µM -0.331098385271415 0.361293298805093 no 2185 0.370285085641667 2965 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3212 9128307 49.47 µM -0.331473260354208 0.361154274187508 no 2186 0.370143517782628 2919 27243542 SGTC_3283 9109332 35.8195 µM -0.331588208162005 0.361111648793094 no 2187 0.370100112405407 2999 17027281 SGTC_1106 tegaserod maleate 11.7 µM -0.332554277272247 0.360753475477915 no 2188 0.369735381020306 3032 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2400 5203494 178.7 µM -0.332848753526133 0.360644321701823 no 2189 0.369624227236487 2972 6777674 SGTC_656 4090-1979 187 µM -0.332859438740249 0.360640361217358 no 2190 0.369620194172145 3120 22330961 SGTC_1258 0671-0043 57.1 µM -0.333148954783373 0.360533057519748 no 2191 0.369510923691933 3037 4298767 SGTC_1387 3342-1166 1.8 µM -0.334425657259137 0.360060002757208 no 2192 0.369029190572959 3043 3418228 SGTC_1957 st077035 62.4 µM -0.336115794588187 0.359434088164349 no 2193 0.368391774131814 3111 705593 SGTC_2304 7443016 91.4 µM -0.336269451738001 0.359377202432425 no 2194 0.368333841979008 2930 939854 SGTC_1457 k015-0032 57.3 µM -0.337053537741915 0.359086972880802 no 2195 0.368038270802389 2970 4302660 SGTC_2546 rhodinyl acetate 100 µM -0.337073285766579 0.359079664195556 no 2196 0.368030827541351 3137 6708682 SGTC_413 propylparaben 100 µM -0.337664343144767 0.35886093950066 no 2197 0.367808074060105 2986 7175 A pharmaceutical preservative. SGTC_2833 9001315 45.46 µM -0.338399013176894 0.358589134497575 no 2198 0.367531258841793 2967 2989378 SGTC_2876 9059903 25.97 µM -0.339319774299018 0.358248582723423 no 2199 0.367184423819838 2984 6916095 SGTC_3202 9113761 49.47 µM -0.339463778125077 0.35819533180191 no 2200 0.367130189823734 3152 4798415 SGTC_2192 5915882 198.485 µM -0.339784093914659 0.358076892682097 no 2201 0.367009563611926 3005 2876149 SGTC_1447 4239-0816 81.9 µM -0.343466214874719 0.356716384812988 no 2202 0.36562387663519 3013 1341554 SGTC_401 neomycin 50 µM -0.345932201205909 0.355806243702622 no 2203 0.364696833948874 3049 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1908 st060353 56.5 µM -0.346619000975646 0.35555290707002 no 2204 0.364438784598462 3224 4227716 SGTC_1976 st070609 63.5 µM -0.34816289373703 0.354983651589548 no 2205 0.363858926499049 2959 682556 SGTC_1648 st011736 69.8 µM -0.348831150451142 0.354737355979879 no 2206 0.36360803796187 3164 2855514 SGTC_3009 9080819 71.4286 µM -0.349012975137263 0.354670352382355 no 2207 0.363539784297543 3086 17027216 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.352859556204066 0.353253918474687 no 2208 0.362096866208111 2939 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1459 k035-0031 35.7 µM -0.353536600909787 0.353004818592079 no 2209 0.361843097230925 2996 3877128 YMR208W ERG12 SGTC_98 0074-0023 107.663 µM -0.353963569245562 0.352847759774099 no 2210 0.361683092760629 3097 3563821 SGTC_2041 5107442 45.335 µM -0.35408578776727 0.352802806730356 no 2211 0.361637296367572 3188 793005 SGTC_1903 st060211 78.3 µM -0.355245855625483 0.352376226001911 no 2212 0.361202707141928 3191 688960 SGTC_330 1488-0319 80.1 µM -0.355261511586098 0.35237047025265 no 2213 0.361196843267259 3099 6846614 SGTC_2385 9074692 200 µM -0.35738196296865 0.351591221478231 no 2214 0.360402938928126 3062 17046906 SGTC_1703 st026983 48.3 µM -0.357403289525661 0.351583387300774 no 2215 0.360394957240857 3179 1104023 SGTC_3011 9081274 71.4286 µM -0.358967411002252 0.351008989090206 no 2216 0.359809734461643 3043 6625322 SGTC_1793 st048256 72.231 µM -0.359529276519014 0.350802736106101 no 2217 0.359599590191329 3020 672022 SGTC_2903 5923464 63.88 µM -0.360613416829503 0.350404887630153 no 2218 0.35919422906159 3138 2876576 SGTC_675 1309-0189 238 µM -0.362999060359573 0.349530002955664 no 2219 0.358302793125055 3088 4246530 SGTC_163 TUB2.036 7.546 µM -0.363347932043359 0.34940212841906 no 2220 0.358172495904265 3149 15992207 YJR013W GPI14 SGTC_3265 9137266 49.47 µM -0.363501400697835 0.349345881821949 no 2221 0.358115183386345 3121 17224265 SGTC_223 busulfan 5 mM -0.363926277803667 0.349190180695661 no 2222 0.357956530684803 3124 2478 A DNA alkylator. SGTC_3059 1327-0034 3 µM -0.363937199052385 0.349186178812311 no 2223 0.357952452921505 3042 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1132 3456-3614 2.5 µM -0.36441548482163 0.349010936565924 no 2224 0.357773887033788 3277 3125502 SGTC_120 rhodamine 6G 52.259 µM -0.364891118501556 0.348836697964332 no 2225 0.357596342153902 3016 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1048 3161-0300 24.5 µM -0.365006132502182 0.348794569738437 no 2226 0.3575534142703 3076 2165101 SGTC_3073 9114972 49.47 µM -0.365710615389015 0.348536566943845 no 2227 0.357290512065544 3155 41905075 SGTC_2551 apiole 73.87 µM -0.367505085608487 0.347879694745032 no 2228 0.356621149538271 3003 10659 A possible DNA adduct former. SGTC_599 1935-0052 86.5 µM -0.368392175622866 0.347555140701183 no 2229 0.356290415414865 3028 9557311 SGTC_2690 usnic acid 100 µM -0.368571143545832 0.347489676367629 no 2230 0.356223703825769 3295 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1860 st056228 74.6 µM -0.369369397523053 0.347197739987264 no 2231 0.355926202486239 3158 688679 SGTC_2229 7354935 190 µM -0.371126773209062 0.346555354545854 no 2232 0.355271555314661 3128 318112 SGTC_9 0092-0002 10.449 µM -0.371917983505025 0.346266281943947 no 2233 0.354976957584605 3129 759368 SGTC_1934 st074720 32.6 µM -0.372931733529626 0.345896034217642 no 2234 0.354599626533417 3022 17250992 SGTC_1978 st071761 42 µM -0.373032580408271 0.345859210379519 no 2235 0.35456209779733 3055 5147680 SGTC_1624 st003710 6.25 µM -0.373170900433444 0.345808705741726 no 2236 0.354510626257249 3180 24207033 SGTC_370 0180-0345 38.7 µM -0.373378271348773 0.345732993768884 no 2237 0.35443346453114 2961 3989527 SGTC_203 k066-0004 30.888 µM -0.37583670920402 0.344835878853908 no 2238 0.353519147590582 3154 6795412 SGTC_2487 5918373 44.05 µM -0.375989761150192 0.344780057044378 no 2239 0.353462253955865 3215 2876279 SGTC_291 SEC14.278 35.5 µM -0.376263775760369 0.344680125616635 no 2240 0.353360403337099 3183 1068044 SGTC_1659 st012954 42.1 µM -0.376753745194773 0.344501463822121 no 2241 0.353178308971457 3183 24207262 SGTC_1745 st081495 74 µM -0.377275821274915 0.344311132872547 no 2242 0.352984319340623 3106 13842402 YBL026W LSM2 SGTC_1772 st048439 82.2 µM -0.377496241559167 0.344230787064914 no 2243 0.3529024284742 3152 2927068 YDL195W SEC31 SGTC_901 1112-0062 60.1 µM -0.378052460452821 0.344028069942773 no 2244 0.352695811515917 3067 1908457 SGTC_3296 9122258 64.045 µM -0.379988028762376 0.343322990801654 no 2245 0.351977150757228 3165 4730474 SGTC_89 0302-0250 142.109 µM -0.382594240477013 0.342374474236456 no 2246 0.351010320682475 3113 4203518 YLR208W SEC13 SGTC_1233 0325-0408 14.2 µM -0.386651976709187 0.340899662140519 no 2247 0.349506936551576 3192 12874 SGTC_1676 st018489 23.4 µM -0.389225633708719 0.339965505650015 no 2248 0.348554621327691 3084 3696235 SGTC_930 2810-3379 265 µM -0.389743312926888 0.339777722799542 no 2249 0.348363182530556 3287 1015764 SGTC_1618 st003135 44.5 µM -0.390517484859286 0.339496974027911 no 2250 0.348076964299541 3171 1270615 SGTC_1605 st000082 49.1 µM -0.391595774395946 0.339106087258526 no 2251 0.347678455298907 3205 1114022 SGTC_1778 st046819 58.9 µM -0.39281923001478 0.338662786526581 no 2252 0.347226500279672 3092 671715 SGTC_350 k064-0020 19.8 µM -0.393659914678029 0.338358306550899 no 2253 0.346916069980638 3264 2790705 SGTC_2848 9016370 25.97 µM -0.394728134805399 0.337971570004121 no 2254 0.346521768391119 3236 7894410 SGTC_2764 methyldopa 94.69 µM -0.39532925949024 0.337754015015852 no 2255 0.346299954213498 3273 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1565 sinapyl alcohol 95.1 µM -0.395976752996342 0.337519739166946 no 2256 0.346061088968198 3193 5280507 A phenol propionate derived from cinnamic acid. SGTC_902 1120-0002 2.07 µM -0.399137959257651 0.336376858259046 no 2257 0.344895776955128 3095 3280475 SGTC_1782 st039423 80.636 µM -0.400160543933715 0.336007482750295 no 2258 0.34451913675128 3129 2068169 SGTC_982 1491-0518 27.5 µM -0.40032100638978 0.335949535260318 no 2259 0.344460048912865 3103 3091256 SGTC_851 0394-0702 453 µM -0.40137076672437 0.335570533634436 no 2260 0.344073584464526 3247 762646 SGTC_2705 st078069 42.8 µM -0.401775671490492 0.335424392970746 no 2261 0.343924564121055 3182 1530061 SGTC_805 3852-0218 479 µM -0.403001878105029 0.334981975049184 no 2262 0.343473421428516 3083 6615355 SGTC_66 0109-0187 42.4 µM -0.40466314359245 0.334382952150413 no 2263 0.342862568664393 3184 759417 SGTC_3275 9138069 49.47 µM -0.406615013592115 0.333679680944056 no 2264 0.342145384279371 3201 17617007 SGTC_3288 9119690 36.221 µM -0.407742272688268 0.333273788144093 no 2265 0.341731449433005 3158 17595618 YKL019W RAM2 SGTC_3007 9078383 71.4286 µM -0.408695914337282 0.332930562243734 no 2266 0.341381416238307 3127 6496995 SGTC_1337 1486-1011 40.3 µM -0.410583067360652 0.332251768197227 no 2267 0.34068914092879 3213 X1337 SGTC_2888 9058547 12.99 µM -0.410686980702039 0.332214407343184 no 2268 0.340651037350319 3101 16476514 SGTC_3194 9111903 49.47 µM -0.41123578973524 0.332017116995792 no 2269 0.340449823683494 3309 17087251 SGTC_3002 9075603 71.4286 µM -0.411892458942732 0.331781113381533 no 2270 0.34020912416605 3180 20105405 SGTC_2185 6113692 200 µM -0.411932271520226 0.331766807086181 no 2271 0.340194533114282 3244 874150 SGTC_1767 st044992 70.3 µM -0.412158186647835 0.331685631142415 no 2272 0.340111741215417 3171 9600693 SGTC_2917 7979103 53.79 µM -0.412820207903566 0.331447798837144 no 2273 0.339869172399649 3269 2980565 SGTC_2882 9058044 58.44 µM -0.413360654166982 0.331253692935392 no 2274 0.33967119857631 3200 18076804 SGTC_3261 9137475 49.47 µM -0.414801856833479 0.330736294391379 no 2275 0.339143480085028 3158 17027690 SGTC_1082 camptothecin 424.86 nM -0.415682095862104 0.330420443359445 no 2276 0.338821322124906 2937 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1214 0358-0031 63.7 µM -0.416460786562272 0.330141130978555 no 2277 0.338536427993201 3341 4301366 SGTC_1071 trifluoperazine 6.31 µM -0.417469652625825 0.329779396619114 no 2278 0.338167458596676 3271 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2456 5770359 74.46 µM -0.418663517845121 0.329351535430979 no 2279 0.337731030781878 3278 3118787 SGTC_2077 5212015 200 µM -0.420065469482014 0.328849384734639 no 2280 0.337218813619066 3120 780900 SGTC_1561 5-methoxyflavone 52.9 µM -0.420363774632175 0.32874257768018 no 2281 0.337109863706829 3197 94525 SGTC_1429 4049-0205 9.46 µM -0.42194785084184 0.328175639574645 no 2282 0.336531541042981 3207 22774478 SGTC_2274 7947094 46.08 µM -0.424211921877659 0.32736601942471 no 2283 0.335705633518518 3162 2971028 SGTC_605 1315-0399 119 µM -0.426890029876451 0.326409389365442 no 2284 0.334729713866644 3288 24020461 SGTC_1463 k081-0032 34.1 µM -0.427074182910585 0.326343651066627 no 2285 0.334662648234427 3218 977755 SGTC_992 3909-8734 162 µM -0.42975020228776 0.325388984725242 no 2286 0.333688680299467 3190 4288319 SGTC_2623 humulene 100 µM -0.429792662813169 0.325373846198267 no 2287 0.33367323531138 3226 6187145 An anti-inflammatory. SGTC_2899 9053889 58.44 µM -0.429941477630046 0.325320791260441 no 2288 0.333619106245146 3263 6470052 SGTC_74 000s-0487 160.283 µM -0.430567285238645 0.325097719278524 no 2289 0.333391516413123 3241 677548 SGTC_557 1315-0110 16.2 µM -0.430941344793745 0.324964413962795 no 2290 0.333255510026504 3132 6833801 SGTC_455 paf C-16 10 µM -0.430950477394928 0.32496115961605 no 2291 0.333252189727512 3159 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1478 0453-0656 35.7 µM -0.432152563296152 0.324532920293651 no 2292 0.332815266876052 3241 5258496 SGTC_2891 9063876 19.48 µM -0.434107256551429 0.32383706227352 no 2293 0.33210527811851 3240 6472478 SGTC_2558 carylophyllene oxide 100 µM -0.434238583699429 0.323790332698808 no 2294 0.332057598695232 3249 6708694 An oxygenated terpenoid and antifungal agent. SGTC_560 2332-1943 155 µM -0.435059449584757 0.323498310481844 no 2295 0.331759638083899 3215 21177716 SGTC_1135 dihydrocapsaicin 536.708 nM -0.435115649200053 0.323478321497852 no 2296 0.331739242451283 3117 107982 A Capsaicinoid. SGTC_1512 0259-0544 12.2 µM -0.435358715291016 0.323391874029036 no 2297 0.331651036084335 3180 18476 SGTC_738 1315-0003 72.4 µM -0.437544358521692 0.322614969632702 no 2298 0.330858306799279 3305 6251474 SGTC_1405 3909-7894 12 µM -0.438095308083948 0.322419252176545 no 2299 0.330658597736819 3265 7104060 SGTC_3193 9111931 49.47 µM -0.438142348427911 0.322402544003464 no 2300 0.330641548711627 3149 17087244 SGTC_804 1595-0054 20.9 µM -0.438702089049499 0.322203758302803 no 2301 0.330438706592937 3167 761523 Stimulates phospholipase C. SGTC_699 0375-0592 111 µM -0.441368210619654 0.321257613314239 no 2302 0.329473226134978 3318 762578 SGTC_861 0443-0273 110 µM -0.441371164242586 0.321256565783209 no 2303 0.329472157170507 3264 6149169 SGTC_1987 st072290 61.9 µM -0.442470535690733 0.320866761861714 no 2304 0.329074373509517 3209 54697379 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.443239425196894 0.320594254127818 no 2305 0.328796282493952 3299 5282362 SGTC_1374 2889-5571 141 µM -0.443407102662385 0.32053483916993 no 2306 0.328735649694391 3216 2853281 SGTC_1437 4092-1038 11.6 µM -0.44571054470576 0.319719101843728 no 2307 0.327903173322476 3197 3977136 SGTC_3118 9124250 49.47 µM -0.445934031230321 0.319640002985673 no 2308 0.327822449492035 3194 1504786 SGTC_2149 5554786 194.827 µM -0.446852842300338 0.319314893287694 no 2309 0.327490657445264 3203 745063 YPR165W RHO1 SGTC_17 0960-0276 49.807 µM -0.447324297421388 0.319148128739425 no 2310 0.327320463051085 3197 6821114 SGTC_2767 sibutramine 71.45 µM -0.448620864406132 0.318689691865533 no 2311 0.32685259001736 3386 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3063 1327-0034 4 µM -0.449310978739562 0.318445796037456 no 2312 0.326603669525401 3265 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2131 toluylene red 5.2905 µM -0.449421154493261 0.318406865700549 no 2313 0.326563936870662 3180 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1642 st009582 77.7 µM -0.449704474006164 0.31830676464247 no 2314 0.326461772460109 3336 6739311 SGTC_1141 3253-0389 52.6 µM -0.449912192308192 0.318233383060459 no 2315 0.326386877953736 3270 5402031 SGTC_2231 micatex 6.853 µM -0.450051513920074 0.318184168282248 no 2316 0.326336648346061 3265 20737 An antifungal of unknown mechanism. SGTC_85 0868-0259 160.055 µM -0.450181577122843 0.318138226895177 no 2317 0.326289759514155 3222 83173 SGTC_678 1218-2179 85.9 µM -0.451348314364742 0.317726233005986 no 2318 0.325869264192584 3260 6820081 YOR116C RPO31 SGTC_270 tamoxifen 5.46 µM -0.451581235024261 0.317644011930849 no 2319 0.325785345438115 3384 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2245 6637752 200 µM -0.451977562671787 0.317504128802921 no 2320 0.325642573229864 3271 681890 SGTC_2455 5377712 9.75 µM -0.454116237541491 0.316749737427651 no 2321 0.324872583432226 3259 2243908 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.454779993992651 0.316515760147156 no 2322 0.324633762221661 3146 6708514 SGTC_909 3448-9333 149 µM -0.456224063686408 0.316006972456296 no 2323 0.324114431488261 3186 3344074 SGTC_20 0481-0013 4.944 µM -0.456590407119969 0.315877954375459 no 2324 0.323982737769168 3265 182045 SGTC_190 3970-0790 3.722 µM -0.457068658566936 0.3157095585102 no 2325 0.323810848328714 3274 2832352 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.459449334625549 0.314871874564627 no 2326 0.322955763729214 3301 521171 SGTC_125 0133-0007 11.75 µM -0.460207130955032 0.314605429658393 no 2327 0.322683776503471 3361 26541 SGTC_1775 st081588 35.1725 µM -0.460909687313191 0.314358493608316 no 2328 0.322431700649608 3316 1426443 YGL099W LSG1 SGTC_3052 9092717 49.47 µM -0.461503194751374 0.314149951017924 no 2329 0.322218814926325 3329 25237534 SGTC_1781 st038725 66.3 µM -0.463017008552766 0.313618306202958 no 2330 0.321676087816839 3188 4270275 YIL048W NEO1 SGTC_3220 9131269 49.47 µM -0.467178808627891 0.312158696494204 no 2331 0.32018597689708 3325 17722206 SGTC_764 1951-2361 146 µM -0.467679412339673 0.311983324676592 no 2332 0.320006932954389 3224 5438930 SGTC_276 colchicine 750 µM -0.469748483857784 0.311258938553941 no 2333 0.319267362028099 3362 2833 A microtubule depolymerizer. SGTC_368 fentichlor 4.58 µM -0.471146430718186 0.310769927722474 no 2334 0.318768085099339 3266 7329 A pesticide. SGTC_2238 6671620 73.2395 µM -0.471847028863802 0.310524979576642 no 2335 0.318517989977788 3223 729941 SGTC_2610 ononetin 44.17 µM -0.4741134265188 0.309733161130014 no 2336 0.317709512302126 3289 259632 SGTC_544 k015-0020 52.4 µM -0.476020519727987 0.309067557149109 no 2337 0.317029879594244 3277 3008304 SGTC_2368 9071271 200 µM -0.47611933174917 0.309033087328242 no 2338 0.316994682643628 3253 27209959 SGTC_2898 9056270 58.44 µM -0.476382062628579 0.308941443841959 no 2339 0.316901105670713 3299 19154699 SGTC_2862 9027634 71.43 µM -0.476935352544806 0.308748488991666 no 2340 0.316704078464829 3187 5012562 SGTC_3326 9140064 16.379 µM -0.477343268468847 0.308606265804717 no 2341 0.316558852401577 3211 1868434 SGTC_854 0422-0053 192 µM -0.477458639426318 0.308566045994076 no 2342 0.316517783208306 3329 3596728 SGTC_1041 0206-0046 107 µM -0.477788353604511 0.308451116021889 no 2343 0.316400425628277 3265 50494 SGTC_585 0kpi-0023 191 µM -0.478128035133399 0.308332731312197 no 2344 0.316279539629307 3312 64601 SGTC_594 1487-1584 10.8 µM -0.478693543500249 0.30813568637505 no 2345 0.316078329837155 3238 5013332 SGTC_3140 9094243 49.47 µM -0.478911804039923 0.308059650764099 no 2346 0.316000686561294 3363 19291112 SGTC_1713 st033146 12.748 µM -0.479616972126852 0.307814047069629 no 2347 0.315749887900361 3387 674619 SGTC_1153 4055-0057 267 µM -0.479660980250447 0.307798722289173 no 2348 0.315734238870317 3235 882706 SGTC_503 tyrphostin 8 294 µM -0.479801658333608 0.307749736747655 no 2349 0.315684216786773 3307 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3348 9149464 3.537 µM -0.47997410673898 0.307689693131339 no 2350 0.315622902469993 3296 1951442 SGTC_2734 clemastine 41.6 µM -0.481433637765037 0.307181715528411 no 2351 0.31510416716666 3270 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1414 3917-0015 5.4 µM -0.481668163673471 0.307100125200227 no 2352 0.315020847726638 3329 6618702 SGTC_2625 euphol 100 µM -0.48226673663346 0.306891928119534 no 2353 0.31480823686245 3372 6708538 A triterpene alcohol. SGTC_1336 1486-0901 104 µM -0.482537990108112 0.306797600584054 no 2354 0.314711908850476 3313 5006114 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.483833247306123 0.306347355461735 no 2355 0.314252108761856 3425 16725076 SGTC_381 3461-2219 42.7 µM -0.485095790683269 0.305908763243441 no 2356 0.313804198905096 3332 2883159 SGTC_2208 7283366 200 µM -0.48524337279315 0.305857513160275 no 2357 0.313751859402034 3353 898663 SGTC_2798 7813637 45.45 µM -0.485420896547628 0.305795870432193 no 2358 0.313688906160477 3359 956368 SGTC_1998 st075797 76.8 µM -0.486078779996869 0.305567477267885 no 2359 0.31345565570624 3372 24208315 SGTC_2677 mitomycin C 100 µM -0.486334331357772 0.30547877953746 no 2360 0.313365070902675 3309 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1418 3966-3099 2.4 µM -0.489045171669033 0.304538594541075 no 2361 0.312404858483147 3355 740335 SGTC_2158 5657123 3.6195 µM -0.48980582731991 0.304275012247244 no 2362 0.312135653381542 3325 2858827 SGTC_422 cantharidin 155 µM -0.49046428390805 0.304046926035569 no 2363 0.311902698717354 3228 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_551 k048-0028 34.9 µM -0.490808580880759 0.303927693562136 no 2364 0.311780920197194 3384 6836383 SGTC_2156 5649887 115 µM -0.491405263589818 0.303721107521703 no 2365 0.311569921080432 3369 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_458 nppb 133 µM -0.491512329821357 0.303684045225095 no 2366 0.311532066831856 3424 4549 A chloride channel blocker. SGTC_3235 9132602 49.47 µM -0.492870862435362 0.30321394783012 no 2367 0.31105191826955 3399 4912240 SGTC_1947 st076332 61.6 µM -0.494445835757041 0.30266936241581 no 2368 0.310495675008573 3379 24208416 SGTC_2147 5545932 89.7195 µM -0.494886598714805 0.302517036395818 no 2369 0.310340085474515 3332 797404 SGTC_2825 7998094 58.44 µM -0.496307087720129 0.302026354763168 no 2370 0.309838883206026 3286 2987815 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.496437399461253 0.301981358888745 no 2371 0.309792921969702 3336 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2413 inermin 26.06 µM -0.499267641847867 0.301004836787992 no 2372 0.308795423828258 3478 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1695 st026914 34.495 µM -0.499976992234309 0.300760312012392 no 2373 0.308545639009125 3284 3289191 SGTC_2937 9044753 11.33 µM -0.500480549546926 0.300586781919055 no 2374 0.308368374223028 3300 6465530 YGL099W LSG1 SGTC_553 k007-0256 45.7 µM -0.501488344519185 0.300239623120331 no 2375 0.308013739342581 3314 6287000 SGTC_2366 9070441 60.58 µM -0.504795909440081 0.29910152998558 no 2376 0.306851094587078 3276 6837235 SGTC_1277 0873-0036 22 µM -0.50530761277063 0.298925634117237 no 2377 0.306671398351976 3390 5965735 SGTC_2431 5490079 200 µM -0.506205113957093 0.298617235396016 no 2378 0.306356332668959 3325 5722345 SGTC_2383 9036125 200 µM -0.506507646181028 0.298513312103884 no 2379 0.306250161683026 3277 79580 SGTC_1372 2752-0194 270 µM -0.508511901789526 0.297825243254663 no 2380 0.305547197276003 3371 823334 SGTC_1720 st037298 9.481 µM -0.509133962875575 0.297611834410364 no 2381 0.305329163635828 3356 597396 SGTC_35 0133-0054 64.071 µM -0.509301029823602 0.297554531087995 no 2382 0.305270618099213 3319 99677 SGTC_1867 st057372 64 µM -0.509314715444446 0.297549837195747 no 2383 0.305265822446032 3383 688837 SGTC_2143 5623677 140.463 µM -0.512328906276986 0.296516855144234 no 2384 0.304210418965972 3361 5375313 SGTC_1906 st060206 94.7 µM -0.512857672891428 0.296335813065999 no 2385 0.304025441748273 3394 5133468 SGTC_818 4072-2707 53.5 µM -0.51308679154598 0.296257381878023 no 2386 0.303945305265061 3283 882871 SGTC_2988 9073640 71.4286 µM -0.513609393186949 0.29607852213684 no 2387 0.303762555498815 3462 9102229 SGTC_2210 7115885 190.385 µM -0.516007196434901 0.295258513096165 no 2388 0.302924691508696 3365 2927039 SGTC_67 0335-0847 266 µM -0.519229937562055 0.294158038629625 no 2389 0.301800202251816 3508 4552207 YOR254C SEC63 SGTC_2338 7999974 200 µM -0.520502230100341 0.293724109315117 no 2390 0.301356786977211 3384 315925 SGTC_2460 5552655 174.22 µM -0.521358660621223 0.293432181219147 no 2391 0.301058471858024 3407 5401989 SGTC_3301 9125354 19.7965 µM -0.521402265654052 0.293417321340121 no 2392 0.301043286749449 3395 41905162 SGTC_268 camptothecin 39.6153 µM -0.523308251455496 0.292768133628345 no 2393 0.300379879878623 3413 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3143 9086658 49.47 µM -0.525586337835061 0.29199308285279 no 2394 0.29958782562626 3384 25236626 SGTC_1861 st057647 17.4 µM -0.525799186840505 0.291920716168569 no 2395 0.299513869794645 3447 688668 SGTC_1722 st034304 3.6505 µM -0.527492011090902 0.291345469257575 no 2396 0.298925981382733 3323 4036148 YLR033W RSC58 SGTC_402 epigallocatechin gallate 10 µM -0.529506510774867 0.290661602358358 no 2397 0.298227064547568 3333 65064 An antioxidant. SGTC_1852 st056254 31.4 µM -0.529739889999308 0.29058242512599 no 2398 0.298146143350843 3294 442583 SGTC_653 0203-0016 55.2 µM -0.530089427241512 0.29046385850757 no 2399 0.298024964591547 3370 295302 SGTC_499 genistein 192 µM -0.533486942380173 0.28931256806377 no 2400 0.296848273772754 3407 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2972 9093619 59.92 µM -0.533626747918458 0.289265239183063 no 2401 0.296799899290067 3272 25236256 SGTC_2779 methotrexate 400 µM -0.53363797357033 0.289261439079875 no 2402 0.296796015229191 3455 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_12 0849-0099 9.267 µM -0.534174644025036 0.289079792993606 no 2403 0.29661035510504 3380 6071388 SGTC_1748 st037455 53.6035 µM -0.536034302282657 0.288450772501797 no 2404 0.29596742180737 3453 580690 SGTC_506 n9-isopropylolomoucine 153 µM -0.536221580624112 0.288387462271696 no 2405 0.29590271018319 3454 6610355 SGTC_519 k048-0011 62.8 µM -0.53641942566542 0.288320587040784 no 2406 0.295834354430198 3390 6836379 SGTC_2711 st079103 59.1 µM -0.536953057508184 0.288140246219891 no 2407 0.295650020018013 3356 54693780 SGTC_536 3852-0578 10.6 µM -0.540614906697175 0.286904162696581 no 2408 0.294386520529158 3464 2869208 SGTC_42 0133-0086 60.653 µM -0.540644661365787 0.286894129093047 no 2409 0.294376264074472 3356 162923 Model of phenazepam hydroxylation. SGTC_3306 9127676 59.7925 µM -0.543043204297906 0.286085861302055 no 2410 0.293550027952978 3388 41905287 SGTC_232 clozapine 119 µM -0.543278892784624 0.28600649674436 no 2411 0.293468897331683 3401 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1406 3909-7906 11.9 µM -0.544580971570811 0.285568229961227 no 2412 0.293020872407997 3433 X1406 SGTC_2584 androsterone 48.74 µM -0.544650550832434 0.28554481927265 no 2413 0.292996940207321 3458 2754130 A steroid. SGTC_1397 3532-0190 20.1 µM -0.545650747572451 0.285208393347007 no 2414 0.292653016854155 3329 5322280 SGTC_1126 isoteolin 1.0172 µM -0.545792162410539 0.285160842332367 no 2415 0.292604405691056 3404 133323 SGTC_2859 9028643 45.46 µM -0.545920739988317 0.285117611151304 no 2416 0.292560210575555 3397 17151580 SGTC_1402 3909-7673 35.9 µM -0.546831784479617 0.28481138343235 no 2417 0.292247152203135 3418 5328014 SGTC_1847 st056231 15 µM -0.546867881590545 0.284799253409449 no 2418 0.292234751515454 3416 5393180 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.547474061702103 0.284595590327544 no 2419 0.292026542891738 3400 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_711 k292-0785 179 µM -0.547553513863367 0.284568901318232 no 2420 0.291999258061246 3427 4146315 SGTC_3096 9117468 49.47 µM -0.547622122822431 0.284545855642616 no 2421 0.291975697872217 3382 41316311 SGTC_1724 st037281 8.293 µM -0.547991792589908 0.28442169930713 no 2422 0.291848769196759 3387 574124 YDL195W SEC31 SGTC_2226 7298446 200 µM -0.548026258686806 0.284410124931875 no 2423 0.291836936333731 3436 3283010 SGTC_3000 9075062 71.4286 µM -0.551198981813989 0.283345628841605 no 2424 0.290748638987035 3351 17057871 SGTC_2122 5258151 111.688 µM -0.551846656381719 0.283128559362108 no 2425 0.290526709189499 3371 2173356 SGTC_1981 st071826 47 µM -0.552969548908886 0.282752408802945 no 2426 0.290142130922701 3401 11838600 SGTC_272 doxorubicin 8.13 µM -0.55306262039531 0.282721242161227 no 2427 0.290110265676959 3435 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_229 benomyl 22.8748 µM -0.553144616214437 0.282693785771369 no 2428 0.29008219380941 3443 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1165 k072-0275 30.3 µM -0.553613682174972 0.282536743156121 no 2429 0.289921630130309 3493 6153523 YGL055W OLE1 SGTC_3195 9113082 49.47 µM -0.554603638153896 0.282205445045309 no 2430 0.289582900001113 3446 17018038 SGTC_1408 3909-7976 48.8 µM -0.555326011279813 0.281963814119495 no 2431 0.28933584517657 3437 24152374 SGTC_3232 9132874 49.47 µM -0.556270677556993 0.281647977479064 no 2432 0.289012914634344 3389 3784940 SGTC_1022 4477-0945 21.3 µM -0.556292150421264 0.281640800295032 no 2433 0.289005576189309 3423 4648966 SGTC_602 3130-1533 38.1 µM -0.556378946189935 0.281611790196602 no 2434 0.28897591425004 3486 720941 SGTC_900 1112-0045 141 µM -0.55642522825904 0.281596321743821 no 2435 0.288960098212884 3407 56211 YIL048W NEO1 SGTC_718 1130-0073 349 µM -0.556812883313478 0.28146677526448 no 2436 0.288827640296195 3532 6740020 SGTC_2258 7960471 200 µM -0.55740696002655 0.281268302657265 no 2437 0.288624705610515 3404 2974708 SGTC_2152 5568786 200 µM -0.557705282879332 0.281168662712186 no 2438 0.288522824826189 3426 5399883 SGTC_1805 st050013 60.3 µM -0.559420327928836 0.280596167968343 no 2439 0.287937445647552 3395 4037144 SGTC_1910 st062352 60.4 µM -0.55958221731025 0.28054215723984 no 2440 0.287882218540627 3384 2245730 SGTC_1189 1431-2119 7.28 µM -0.562215929993562 0.279664186057787 no 2441 0.286984454583602 3498 3107275 SGTC_136 0097-0015 404.482 µM -0.562879561351982 0.279443169260801 no 2442 0.286758449321333 3486 4861337 SGTC_2382 9035899 200 µM -0.563871715387931 0.279112899076132 no 2443 0.286420720335346 3432 6462679 SGTC_1740 st038286 13.222 µM -0.564356767281928 0.278951503149754 no 2444 0.286255677523725 3496 716786 SGTC_791 1348-1292 225 µM -0.56519583205414 0.278672420392223 no 2445 0.28597028565391 3488 5437054 SGTC_1730 st033808 45.1 µM -0.568529212167774 0.277565043948429 no 2446 0.284837837914131 3346 1045166 SGTC_1912 st060209 90.8 µM -0.568720812565506 0.277501458118181 no 2447 0.284772810677658 3398 688787 SGTC_6 0844-0013 19.835 µM -0.569086439667656 0.27738013834344 no 2448 0.284648740201215 3541 1584900 SGTC_969 1313-0238 134 µM -0.569533225588117 0.277231924243445 no 2449 0.28449716465233 3397 5212874 SGTC_728 3030-5151 22.5 µM -0.569724153266855 0.27716859884928 no 2450 0.284432402733719 3485 3125388 SGTC_2405 ticlatone 3.52 µM -0.569917596076594 0.277104446474529 no 2451 0.284366794876529 3258 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2113 5491891 107.031 µM -0.569925919766327 0.277101686212103 no 2452 0.284363971985081 3436 789979 SGTC_1180 1193-0155 285 µM -0.572321552234309 0.276307817654157 no 2453 0.283552075623717 3479 2921347 SGTC_26 0302-0163 425.158 µM -0.573613274778468 0.275880228069609 no 2454 0.283114763359298 3432 3100915 SGTC_1239 0337-0584 35.4 µM -0.573924746167736 0.275777172609661 no 2455 0.283009363267069 3543 914301 YML130C ERO1 SGTC_164 4100-3994 89.624 µM -0.575809404224192 0.275154006193994 no 2456 0.282372008157782 3536 4615967 SGTC_3179 9107801 49.47 µM -0.575943889133458 0.275109564975612 no 2457 0.282326554354206 3448 4818259 SGTC_1525 8-methoxypsoralen 92.5 µM -0.576182437927425 0.275030744017573 no 2458 0.282245937240382 3545 4114 Related to psoralen; DNA damaging agent. SGTC_976 1348-1067 47.6 µM -0.577193464210048 0.274696805668047 no 2459 0.281904385848194 3491 5310671 YGL099W LSG1 SGTC_1879 gemcitabine 100 µM -0.577383720603778 0.274633987024982 no 2460 0.281840134480572 3459 60750 A nucleoside analog which inhibits DNA replication. SGTC_2511 berberine 10.47 µM -0.577857944017762 0.274477439316386 no 2461 0.281680015511479 3450 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3020 9089140 49.47 µM -0.578084858718103 0.274402547214587 no 2462 0.281603414508345 3500 17217859 SGTC_1264 0783-0040 158 µM -0.578923181096098 0.274125950454052 no 2463 0.281320503971747 3415 2855798 SGTC_2497 7-hydroxyflavone 100 µM -0.579418645353119 0.273962541361191 no 2464 0.281153363066171 3502 5281894 SGTC_1587 estradiol valerate 56.1 µM -0.57983418199941 0.273825530330709 no 2465 0.281013222091099 3520 13791 A steroid. SGTC_277 nystatin 15.5 µM -0.582073214666913 0.273087858595746 no 2466 0.280258683114802 3414 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_799 1310-0557 151 µM -0.582894777165859 0.272817433822383 no 2467 0.27998206838826 3527 5354492 SGTC_1401 3807-4679 7.6 µM -0.583092436817433 0.272752392178865 no 2468 0.279915537434262 3486 3291456 SGTC_1874 staurosporine 7.6 µM -0.583905119457359 0.272485052693122 no 2469 0.279642074329307 3504 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2895 9054447 58.44 µM -0.585871870992631 0.271838610509084 no 2470 0.278980810710402 3473 2697450 SGTC_91 0417-1751 58.384 µM -0.586433858962331 0.271654033638404 no 2471 0.278791998238367 3550 6795624 SGTC_1454 4239-0054 42.6 µM -0.587041379977915 0.271454572300617 no 2472 0.278587957900727 3594 1340767 SGTC_2168 5727979 200 µM -0.588703204501517 0.270909334981849 no 2473 0.278030193939755 3457 695210 SGTC_2844 9010103 25.97 µM -0.589306791025656 0.270711436275774 no 2474 0.277827745058989 3524 2480525 SGTC_1953 st076800 12.1 µM -0.589493440073497 0.27065025402269 no 2475 0.27776515569735 3428 297591 SGTC_820 1582-0060 59.9 µM -0.590976180379011 0.270164467576284 no 2476 0.277268190472256 3423 3848840 SGTC_2325 6158266 200 µM -0.591057161994791 0.270137948339828 no 2477 0.277241060658086 3466 3623240 SGTC_2785 7756463 72.73 µM -0.592186016587481 0.26976841535907 no 2478 0.276863016071472 3436 2201551 SGTC_755 1995-0008 37.3 µM -0.593090313829128 0.269472574435977 no 2479 0.276560356223565 3521 689533 SGTC_710 3448-4187 58 µM -0.593128618551317 0.269460046633578 no 2480 0.276547539571979 3522 3946412 SGTC_2707 st078556 66.6 µM -0.593497606751494 0.269339381654871 no 2481 0.276424092079445 3462 17250899 SGTC_621 3584-0052 32.1 µM -0.593854432052318 0.269222719911841 no 2482 0.276304739476257 3541 2273927 SGTC_2993 9054257 71.4286 µM -0.594073794140788 0.269151013467222 no 2483 0.276231378765378 3502 6470217 YGL055W OLE1 SGTC_1049 3226-0134 66 µM -0.594250883909555 0.269093132252726 no 2484 0.276172162053602 3532 5702385 SGTC_2652 actinonin 100 µM -0.594279558950439 0.26908376049658 no 2485 0.276162574047252 3488 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1883 5-benzylidenerhodanine 20 µM -0.598140718104641 0.267823330154877 no 2486 0.274873021572755 3497 1273210 SGTC_2513 baicalein 25.65 µM -0.598300375049899 0.267771276114447 no 2487 0.27481976320271 3469 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2841 9004761 38.96 µM -0.598776280183947 0.267616143774221 no 2488 0.274661040934817 3408 2991039 SGTC_1787 fluconazole 80 µM -0.598922605908228 0.267568454611243 no 2489 0.27461224796392 3472 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.599936694954181 0.267238069617537 no 2490 0.274274212949441 3500 688662 SGTC_1149 3909-7961 23.3 µM -0.600073218381965 0.267193606716272 no 2491 0.274228720119751 3485 735261 SGTC_1667 st014849 34.6 µM -0.600800994466749 0.266956647883081 no 2492 0.273986270843516 3537 5348460 SGTC_2782 7736369 71.43 µM -0.601559855003064 0.266709681260095 no 2493 0.273733579056276 3508 2950836 YOL077C BRX1 SGTC_1232 0279-0259 161 µM -0.603918074956354 0.265942950477742 no 2494 0.27294905554173 3517 1560000 SGTC_2791 5663188 71.43 µM -0.604247378827288 0.265835972456936 no 2495 0.272839592777601 3515 54690634 SGTC_305 1682-2595 20.8 µM -0.60525194542946 0.265509762638367 no 2496 0.272505802845579 3510 226033 SGTC_3339 9145883 14.936 µM -0.605495686401612 0.265430644008102 no 2497 0.272424844982647 3496 2030670 SGTC_1996 st072960 66.8 µM -0.606210393888433 0.26519871803809 no 2498 0.272187525834992 3549 1719405 SGTC_2151 5563267 85.4165 µM -0.606754256168102 0.265022301120089 no 2499 0.272007004836498 3486 5310824 SGTC_2858 9025781 8.96 µM -0.607175614730922 0.264885662706696 no 2500 0.271867186720006 3572 4894980 YPL153C RAD53 SGTC_1342 1486-1464 234 µM -0.607718071555243 0.264709807210494 no 2501 0.27168723760416 3555 3253938 SGTC_2237 6667747 47.222 µM -0.607939077053251 0.264638177922844 no 2502 0.271613940488619 3386 729940 YDL015C TSC13 SGTC_645 0845-0943 5.41 µM -0.608641668185791 0.26441052917616 no 2503 0.271380989522877 3484 1885106 SGTC_2265 7929201 200 µM -0.608912475667873 0.264322810619468 no 2504 0.271291227240103 3514 1265108 SGTC_1567 st069303 68.4 µM -0.608933323290186 0.264316058379889 no 2505 0.271284317667237 3543 5581319 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.609277989167035 0.264204438878792 no 2506 0.271170097019027 3492 688664 SGTC_957 1187-1561 14.1 µM -0.609645863102772 0.264085329975996 no 2507 0.271048211789901 3514 1538454 SGTC_87 0100-0052 35.5 µM -0.611400469424312 0.263517606507393 no 2508 0.270467245978575 3605 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_784 4579-0127 173 µM -0.612503328272345 0.263161082647255 no 2509 0.270102398312974 3576 1948547 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.613923266707285 0.26270241886791 no 2510 0.269633017252492 3513 2333 A French combination drug. SGTC_988 1497-1057 103 µM -0.614121912960527 0.262638285441739 no 2511 0.269567384475769 3563 3533044 SGTC_345 1362-0200 395 µM -0.615621773478327 0.262154310564168 no 2512 0.269072088699795 3470 1419823 SGTC_1292 0kpi-0043 232 µM -0.616380814656455 0.261909557490606 no 2513 0.268821606293474 3498 3333905 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.619354143470782 0.260951936450343 no 2514 0.267841541637202 3611 688801 SGTC_2996 9066192 71.4286 µM -0.619483414075759 0.260910343101933 no 2515 0.267798972497319 3518 6472854 SGTC_735 3076-0345 636 µM -0.620678331651544 0.260526034949839 no 2516 0.267405644535038 3592 2888990 SGTC_776 4476-4378 112 µM -0.62253073446615 0.259930843744268 no 2517 0.266796470392394 3541 2892008 SGTC_2565 isoliquiritigenin 100 µM -0.623210130729102 0.259712724442685 no 2518 0.26657322262431 3509 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3231 9132313 49.47 µM -0.624700619648015 0.259234536050088 no 2519 0.266083783185518 3522 4905967 SGTC_407 eburnamonine 100 µM -0.625551592097728 0.258961725720108 no 2520 0.26580454925858 3469 3195 SGTC_2529 gangaleoidin 93.61 µM -0.625909537211408 0.258847017712835 no 2521 0.265687139297086 3583 4565183 SGTC_2583 asiatic acid 100 µM -0.628042019761671 0.258164182171482 no 2522 0.264988206822303 3593 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1719 st032227 49.2 µM -0.628993330411409 0.257859867487747 no 2523 0.26467671132753 3573 3125804 SGTC_2301 7769476 200 µM -0.629815353339915 0.257597060635179 no 2524 0.264407699640401 3537 977820 SGTC_3310 9130229 44.1445 µM -0.634513430825098 0.256097723794631 no 2525 0.262872902241443 3558 7761258 SGTC_1000 4048-0884 8.67 µM -0.636307024976382 0.255526521927251 no 2526 0.26228816353053 3575 13040088 SGTC_924 2046-0044 21.3 µM -0.638835363174688 0.25472245959586 no 2527 0.261465020215998 3592 3623589 SGTC_2386 9075165 157.42 µM -0.639150380528212 0.254622370646205 no 2528 0.261362553989462 3538 16452277 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.640488976947786 0.254197294681643 no 2529 0.260927376613871 3592 688798 SGTC_1383 3049-0032 20.7 µM -0.641488476573945 0.253880142924284 no 2530 0.260602682695718 3607 712864 SGTC_671 0560-0003 407 µM -0.642275012697018 0.253630712832271 no 2531 0.260347317664907 3510 3238678 SGTC_1712 st032288 53.4 µM -0.64273099513777 0.25348616846497 no 2532 0.260199332695827 3596 2883011 SGTC_1184 1269-1718 139 µM -0.644862536485349 0.252811054041808 no 2533 0.259508135712916 3599 5403821 SGTC_2067 5224629 34.075 µM -0.64511784973895 0.252730253242214 no 2534 0.259425408671773 3585 2835000 SGTC_2282 7944268 200 µM -0.645432843046596 0.252630583813439 no 2535 0.259323362770852 3635 2970414 SGTC_2012 4023501 200 µM -0.645952607801724 0.252466166371974 no 2536 0.259155024036117 3531 3477460 SGTC_3030 9087619 49.47 µM -0.646083432790359 0.252424791323424 no 2537 0.259112662012542 3553 25236973 SGTC_3162 9099653 49.47 µM -0.646610614230949 0.252258099782542 no 2538 0.258941993355018 3572 25237511 SGTC_1195 1502-0147 41.1 µM -0.646639485617357 0.252248972503763 no 2539 0.258932648270321 3609 817940 SGTC_1518 st038567 90.8 µM -0.646796437540199 0.252199357429013 no 2540 0.258881849154985 3592 77966 SGTC_2691 st077356 60.2 µM -0.647509474454223 0.251974019592214 no 2541 0.258651132311661 3623 2839272 SGTC_694 1315-0438 43.2 µM -0.647611264708107 0.251941859946342 no 2542 0.258618204797266 3539 6793154 SGTC_366 0181-0206 4.31 µM -0.649265866643671 0.251419408408361 no 2543 0.258083272147585 3615 274874 SGTC_2323 6148992 148.28 µM -0.649629224962309 0.251304752338468 no 2544 0.257965875323221 3543 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2148 5546263 113.568 µM -0.650945472685062 0.250889647892751 no 2545 0.257540843119098 3568 792097 SGTC_198 3454-2873 16.191 µM -0.652220015813212 0.250488041938745 no 2546 0.257129624721633 3580 710957 SGTC_393 acivicin 6.25 µM -0.652402191196565 0.2504306666835 no 2547 0.257070875585665 3525 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_667 1498-1044 59 µM -0.653751423625885 0.250005949372715 no 2548 0.256635983507573 3612 6739982 SGTC_2063 5246145 200 µM -0.655346368843526 0.249504378888535 no 2549 0.256122386489845 3634 711240 SGTC_450 aminopyrene 156 nM -0.656379109677435 0.249179893084664 no 2550 0.255790114119258 3573 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2666 tannic acid 100 µM -0.65646023146947 0.249154414235556 no 2551 0.255764023659906 3630 16134267 A thiamine antagonist. SGTC_2330 7979373 200 µM -0.656825938966228 0.24903956950526 no 2552 0.255646421756867 3577 1863007 SGTC_1021 4476-0760 85.3 µM -0.657195557602397 0.248923525167165 no 2553 0.255527590834432 3567 746768 SGTC_1194 1488-0194 225 µM -0.658301130267365 0.248576594800074 no 2554 0.25517232592872 3579 1391452 SGTC_482 fipronil 114 µM -0.658434991684884 0.248534606375145 no 2555 0.255129328415509 3632 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2367 9070478 135.38 µM -0.658599986870655 0.248482857394451 no 2556 0.255076335665038 3586 572802 SGTC_2829 7992743 58.44 µM -0.658847888371611 0.248405116527457 no 2557 0.254996726092307 3573 16462845 SGTC_1822 st052468 42 µM -0.658879137600141 0.248395317821082 no 2558 0.254986691828759 3573 2873678 SGTC_2213 7173844 200 µM -0.659242214859191 0.248281484116213 no 2559 0.254870121284172 3593 892728 SGTC_2288 7946289 167.31 µM -0.660786594780457 0.247797593732451 no 2560 0.254374590407136 3643 1246052 SGTC_3168 9103419 49.47 µM -0.661133553958926 0.247688952604517 no 2561 0.254263334336648 3564 16649256 SGTC_806 3966-4455 5.86 µM -0.662385260649921 0.247297225134207 no 2562 0.25386217370476 3536 714982 SGTC_1458 k015-0034 6.33 µM -0.663033459181623 0.247094498614128 no 2563 0.253654562601323 3580 3598957 SGTC_285 1486-1325 46 µM -0.663471624967774 0.24695751099552 no 2564 0.253514273284217 3622 22310230 SGTC_1471 k673-0312 37 µM -0.666027069321254 0.246159390292307 no 2565 0.252696899195947 3623 24099884 SGTC_200 k038-0079 37.545 µM -0.667522426547579 0.245693000147229 no 2566 0.252219244758201 3586 3436683 SGTC_2093 5331342 194.4 µM -0.667694029934345 0.245639508769232 no 2567 0.252164460821989 3628 33839 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.669110670712663 0.245198159394444 no 2568 0.251712441797498 3593 756377 SGTC_1653 st012112 65 µM -0.670471992717335 0.244774446455365 no 2569 0.251278477277743 3635 720429 SGTC_855 0428-0020 25 µM -0.670504841690515 0.244764227049671 no 2570 0.251268010516977 3613 6812414 SGTC_518 1021-0119 62.6 µM -0.672973581030583 0.243996853168216 no 2571 0.250482049295953 3581 1097762 SGTC_309 k408-0051 1.48 µM -0.673334646940168 0.243884729655553 no 2572 0.250367207700277 3619 3640463 SGTC_3128 9127691 49.47 µM -0.673807373565608 0.243737973650807 no 2573 0.250216893199455 3595 41316314 SGTC_879 0831-1030 162 µM -0.674031088798808 0.243668538814283 no 2574 0.250145774389133 3657 1549252 SGTC_2123 5259487 200 µM -0.674490759476595 0.243525903651837 no 2575 0.249999679274407 3613 2173474 SGTC_1037 k284-1091 78.7 µM -0.674547438638673 0.243508319311659 no 2576 0.249981668321087 3615 3334711 SGTC_802 4112-3352 742 µM -0.675688703091766 0.243154395449961 no 2577 0.249619154961174 3675 704594 SGTC_2206 7254556 146.969 µM -0.675741693496178 0.243137969060768 no 2578 0.249602329777361 3631 4398905 SGTC_2035 5154463 94.595 µM -0.676714179266166 0.242836616724612 no 2579 0.24929365915003 3628 2769623 SGTC_1152 3909-8331 15.9 µM -0.676956721530734 0.242761489619194 no 2580 0.24921670695894 3622 16001939 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.677329554632599 0.242646029657375 no 2581 0.249098441598097 3670 368090 SGTC_92 0063-0024 660.874 µM -0.679601439724998 0.241943109171807 no 2582 0.248378428907033 3687 3594437 SGTC_3311 9131146 2.8755 µM -0.680870735429147 0.241550870992204 no 2583 0.247976643422644 3640 4900406 YPR165W RHO1 SGTC_97 0535-0701 19.132 µM -0.681040179629553 0.241498535426947 no 2584 0.247923033457371 3600 2832013 YGL099W LSG1 SGTC_1400 3771-8998 51.5 µM -0.682490895292249 0.241050710746597 no 2585 0.247464298976348 3598 670767 SGTC_1439 4092-1168 46 µM -0.684752132670267 0.240353585677105 no 2586 0.246750172830954 3640 2886240 SGTC_1059 3448-6867 171 µM -0.686456065737302 0.239829000465656 no 2587 0.246212780009071 3625 3934407 SGTC_261 5-fluorouridine 15.376 µM -0.687243978911355 0.239586639141573 no 2588 0.245964497344124 3673 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3119 9125183 49.47 µM -0.687711666039567 0.239442842293841 no 2589 0.245817186030576 3529 22695334 SGTC_481 bay k-8644 50 µM -0.688759422626017 0.239120866236504 no 2590 0.245487337373764 3623 2303 A calcium channel antagonist. SGTC_50 0929-0078 56.389 µM -0.690828277362687 0.238485801786183 no 2591 0.244836731487519 3572 1377751 SGTC_225 nsc-122657 1.016 µM -0.691460784178036 0.238291829269984 no 2592 0.244638008452259 3614 275685 SGTC_394 menadione 8.33 µM -0.691626410548989 0.238241050479483 no 2593 0.244585985778008 3622 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1452 4194-0072 190 µM -0.692301510112328 0.238034135481293 no 2594 0.244374000977383 3690 1343545 SGTC_1691 st019933 84.6 µM -0.692375911121926 0.238011337932032 no 2595 0.244350644729276 3640 6176082 SGTC_2115 tiliquinol 12.7705 µM -0.692669357281293 0.237921433440015 no 2596 0.24425853672532 3657 71208 A bioactive hydroxyquinoline. SGTC_2737 bleomycin 30.5 nM -0.69329899958936 0.237728589792669 no 2597 0.244060965369259 3685 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_961 1252-1571 372 µM -0.693480862304829 0.237672905767947 no 2598 0.244003915900767 3668 6813498 SGTC_648 0375-0473 33.3 µM -0.694154405684217 0.237466737789868 no 2599 0.243792691219928 3674 1713139 SGTC_552 k242-0005 476 µM -0.694372350532709 0.237400047081846 no 2600 0.243724364378061 3694 4088318 SGTC_430 0958-0115 16.4 µM -0.694901342416488 0.237238219352835 no 2601 0.243558565682406 3650 6833180 SGTC_750 4073-0104 132 µM -0.695644527668245 0.237010968579573 no 2602 0.243325736614346 3536 22330957 SGTC_2407 paclitaxel 400 µM -0.696381972525166 0.236785591408672 no 2603 0.243094824876999 3786 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2874 9043904 71.43 µM -0.698762197603418 0.236058954113087 no 2604 0.242350328287221 3648 4463428 SGTC_595 3909-8003 73.7 µM -0.699687334068949 0.235776859520033 no 2605 0.242061294073141 3715 699517 SGTC_1334 1486-0610 236 µM -0.700874341712699 0.235415187009697 no 2606 0.241690719150346 3692 3742339 SGTC_2969 9091408 28.7 µM -0.70104530339172 0.235363121479125 no 2607 0.241637371573229 3648 4286311 SGTC_2560 caryophyllene 100 µM -0.702071210078431 0.235050820238473 no 2608 0.241317377804238 3724 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_867 0518-0118 155 µM -0.702712912157265 0.2348555930249 no 2609 0.241117339614169 3703 6848158 SGTC_826 1683-5028 118 µM -0.704418306429644 0.234337190949188 no 2610 0.240586154417482 3718 722377 SGTC_416 estradiol valerate 100 µM -0.705801087574687 0.233917321469617 no 2611 0.240155922822389 3697 13791 A steroid. SGTC_2461 5755302 26.15 µM -0.706318715283298 0.233760255596322 no 2612 0.239994978667042 3674 2788904 SGTC_2051 5263410 176 µM -0.706580408523449 0.233680871208309 no 2613 0.239913633700936 3733 227584 SGTC_2827 7993847 71.43 µM -0.711256685755157 0.232264849535235 no 2614 0.238462593628859 3685 2985692 SGTC_2167 5876490 200 µM -0.712693498079018 0.23183072973036 no 2615 0.238017720368493 3805 686534 SGTC_2372 9071633 200 µM -0.714451518302653 0.231300175260432 no 2616 0.237474012485238 3729 21321366 SGTC_321 4534-3890 65.3 µM -0.715104319436032 0.231103338403782 no 2617 0.237272292553 3718 699746 SGTC_296 1222-0039 74.9 µM -0.715206616829674 0.231072501500827 no 2618 0.237240690503066 3655 5984176 SGTC_2072 5231554 129 µM -0.715872437718875 0.23087185012648 no 2619 0.237035059410728 3755 789545 SGTC_888 0916-0002 6.97 µM -0.71923310254544 0.229860568501673 no 2620 0.235998653296687 3761 2802138 YIL048W NEO1 SGTC_2034 5197015 53.07 µM -0.721897702947123 0.229060510399171 no 2621 0.235178686820259 3698 780676 SGTC_2847 9005661 71.43 µM -0.723369678597168 0.228619213882974 no 2622 0.234726397323122 3646 2991449 SGTC_887 0885-0007 9.62 µM -0.723592211814349 0.228552540266934 no 2623 0.234658062088902 3756 5719458 SGTC_511 blebbistatin 171 µM -0.72462492760856 0.228243269244905 no 2624 0.234341080992294 3750 3476986 A myosin inhibitor. SGTC_204 PMA1.184 62.41 µM -0.726595781785621 0.227653704023776 no 2625 0.233736806521285 3742 2252213 YGL008C PMA1 SGTC_1930 st074634 34.3 µM -0.730654578097942 0.226442252693225 no 2626 0.232495083096652 3668 684253 YOR116C RPO31 SGTC_24 0417-1663 219 µM -0.731077063178232 0.226316360767727 no 2627 0.2323660417109 3684 4329390 SGTC_2079 5212404 121 µM -0.733970003089069 0.225455386727282 no 2628 0.23148351021628 3699 758462 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.734294085848019 0.225359051388983 no 2629 0.231384760804466 3580 6708630 An antioxidant. SGTC_337 1315-0038 354 µM -0.735020765008623 0.225143126856077 no 2630 0.231163423954129 3724 1626437 SGTC_177 1327-0068 8.361 µM -0.735314646296891 0.225055836634965 no 2631 0.231073945166109 3737 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_174 3553-0389 74.3 µM -0.735979790244591 0.224858342793449 no 2632 0.230871498490124 3703 738071 SGTC_2013 4024628 200 µM -0.738449139743263 0.224126006225957 no 2633 0.230120781451589 3751 5230760 SGTC_1725 st036284 20.55 µM -0.738751571650734 0.224036407009835 no 2634 0.230028931859076 3762 707914 SGTC_2863 9028737 58.44 µM -0.738919921102298 0.223986540207195 no 2635 0.229977812451348 3734 6460917 SGTC_262 fenpropimorph 62.5 µM -0.740355886859026 0.223561449077525 no 2636 0.229542039124149 3684 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2860 9025725 38.96 µM -0.741396680899753 0.223253628258056 no 2637 0.229226478185131 3736 40546248 SGTC_3117 9124945 49.47 µM -0.741575610097141 0.223200733231791 no 2638 0.229172252711214 3666 17592065 SGTC_2026 5148700 152 µM -0.741930363912729 0.223095882051422 no 2639 0.2290647638969 3742 79838 SGTC_1802 st050112 57.9 µM -0.741939150634104 0.223093285400503 no 2640 0.229062101918723 3741 4662563 SGTC_2311 7694451 200 µM -0.743202380854258 0.222720154871085 no 2641 0.228679581072372 3708 2163142 SGTC_2746 daunorubicin 9.88 µM -0.744049257176167 0.222470205443511 no 2642 0.228423338014443 3629 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2071 5230951 39.92 µM -0.744408561190538 0.222364207811561 no 2643 0.228314670597552 3777 1799272 SGTC_324 1315-0088 19.6 µM -0.744543219130334 0.222324490037417 no 2644 0.228273952319874 3672 6787421 SGTC_2105 5350118 200 µM -0.744658796379052 0.222290403399722 no 2645 0.228239006975115 3761 2133313 SGTC_2496 diffractaic acid 79.83 µM -0.74501403568186 0.222185653062764 no 2646 0.228131617468243 3775 94870 An apoptosis inducer which activates caspases. SGTC_292 k038-0015 474 µM -0.745657276442435 0.221996050690159 no 2647 0.227937236900583 3727 46368540 SGTC_2738 aclarubicin 5.55 µM -0.746560976778229 0.221729831083605 no 2648 0.227664305671375 3683 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1746 st038117 42 µM -0.749782378726315 0.220782328862819 no 2649 0.226692891636272 3807 2898218 SGTC_2965 9082772 38.63 µM -0.752112190516682 0.220098514884367 no 2650 0.225991796759579 3745 16459634 SGTC_2923 7992654 58.14 µM -0.752558013814167 0.219967801641824 no 2651 0.225857777959426 3792 2985126 SGTC_3072 9116419 49.47 µM -0.753755024316811 0.219617064364164 no 2652 0.225498167442081 3776 17170162 SGTC_2262 9014885 67.46 µM -0.754428162769743 0.219419968543403 no 2653 0.225296083043192 3686 6457424 SGTC_2645 abamectin 100 µM -0.75607335433992 0.218938682265438 no 2654 0.224802608300973 3729 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2318 6029776 164 µM -0.758392973836868 0.218261130813274 no 2655 0.224107881427837 3756 818325 SGTC_1955 wogonin 32.4 µM -0.75887064992821 0.218121753725142 no 2656 0.223964968832871 3818 5281703 A flavanone. SGTC_364 0083-0097 67.7 µM -0.760593043183288 0.217619617259099 no 2657 0.223450088142193 3849 5207356 SGTC_3355 9151058 44.0485 µM -0.760876901377687 0.217536926973674 no 2658 0.223365298158896 3785 17015728 SGTC_172 1112-0046 2.638 µM -0.762423600927051 0.217086679096209 no 2659 0.222903612397699 3739 2802135 YIL048W NEO1 SGTC_931 2812-0076 566 µM -0.763651560670075 0.21672960088887 no 2660 0.222537457086362 3798 3450959 SGTC_3104 9120930 49.47 µM -0.764655475870109 0.216437925081366 no 2661 0.222238362763671 3802 17014836 SGTC_2235 salicylic acid 500 µM -0.764685735589505 0.216429137002399 no 2662 0.222229351112322 3770 338 A COX inhibitor and kinase inhibitor. SGTC_3345 9148410 3.559 µM -0.764721418646808 0.21641877413379 no 2663 0.222218724603866 3729 4903596 SGTC_2686 alizarin 95.37 µM -0.764742335019705 0.216412699854373 no 2664 0.222212495787723 3792 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.76529800607855 0.216251364735728 no 2665 0.222047055549843 3771 6857784 SGTC_1671 st016596 74.5 µM -0.765490905589585 0.21619537402895 no 2666 0.221989639922781 3831 2829167 SGTC_1834 st055981 52.8 µM -0.767089625627933 0.215731655270881 no 2667 0.221514114831264 3830 471719 YDL150W RPC53 SGTC_3151 9099821 49.47 µM -0.767720062751583 0.215548951667543 no 2668 0.221326757100452 3731 17174189 SGTC_116 0155-0182 31.788 µM -0.768539757024566 0.215311534703479 no 2669 0.22108329017367 3747 771486 SGTC_1923 st058458 19.1 µM -0.772631106313164 0.214128783854475 no 2670 0.219870364874172 3803 3534982 SGTC_2955 9076254 12.21 µM -0.77288831648529 0.214054554582594 no 2671 0.21979423991262 3743 16459619 SGTC_1646 st011709 75.6 µM -0.773319596538762 0.213930123429886 no 2672 0.21966663048466 3731 5757843 SGTC_1965 Pectolinarigenin 58.4 µM -0.773556797394209 0.213861705164942 no 2673 0.219596464375627 3784 5320438 An anti-inflammatory. SGTC_3295 9122362 53.5725 µM -0.773752263183302 0.213805334548191 no 2674 0.219538653543087 3829 4730473 SGTC_2259 7964009 200 µM -0.774133386034415 0.21369544695301 no 2675 0.219425958043958 3812 313134 SGTC_1948 st076329 66.6 µM -0.774211115000998 0.213673039717231 no 2676 0.219402978185383 3680 24208413 SGTC_2941 9056145 11.23 µM -0.775278394206747 0.213365509378132 no 2677 0.219087586717914 3666 2119517 SGTC_2811 7967822 32.47 µM -0.775360009721261 0.213342002964069 no 2678 0.219063479268261 3858 2232244 SGTC_1388 3346-4487 254 µM -0.775825202686999 0.213208049689291 no 2679 0.218926100503493 3848 3345614 SGTC_377 3970-0964 33.1 µM -0.776611762416122 0.212981669807212 no 2680 0.218693929878763 3780 16481235 SGTC_2010 4012422 159 µM -0.777678167044125 0.212674971806886 no 2681 0.218379383224738 3797 952393 SGTC_1863 st057641 20.1 µM -0.779471936945188 0.212159665672642 no 2682 0.217850881202161 3819 3921635 SGTC_739 1486-1183 203 µM -0.779500763515446 0.212151390469457 no 2683 0.217842393998972 3757 4346692 SGTC_2602 kawain 100 µM -0.779893685342252 0.21203861376787 no 2684 0.21772672782155 3751 5369129 SGTC_1742 st038235 28.8875 µM -0.781154110200882 0.211677082425672 no 2685 0.217355930060345 3848 564103 YBR002C RER2 SGTC_2696 st077691 74.316 µM -0.782197393118017 0.211378107634386 no 2686 0.217049288156356 3800 757133 SGTC_966 1300-0360 30.2 µM -0.784466734556039 0.210728634601611 no 2687 0.21638314687931 3799 70588 SGTC_2571 chrysanthemic acid 100 µM -0.78465032221839 0.210676144052988 no 2688 0.216329308439781 3838 2743 An insecticide. SGTC_325 2810-4341 181 µM -0.785661609394066 0.210387138962606 no 2689 0.216032880030997 3799 774970 SGTC_793 0488-0545 106 µM -0.787924048965643 0.209741423667627 no 2690 0.215370566620245 3815 292548 SGTC_933 2914-0560 114 µM -0.788755058433143 0.209504540952826 no 2691 0.215127590536515 3855 463887 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.791470478771372 0.208731597242466 no 2692 0.214334748266552 3784 7104 SGTC_3157 9099274 49.47 µM -0.793276425635478 0.208218466778448 no 2693 0.213808394322427 3769 17217662 SGTC_2612 dictamnine 15.46 µM -0.793365690647629 0.208193122894599 no 2694 0.213782397042199 3815 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1076 itraconazole 331 nM -0.794403312417703 0.207898657674371 no 2695 0.213480338223207 3821 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1678 st019265 80.2 µM -0.796099579087657 0.20741780653902 no 2696 0.212987079401119 3801 5367020 SGTC_2112 5488546 200 µM -0.797981430139098 0.206885116689515 no 2697 0.212440633231113 3805 600757 SGTC_2174 5790901 200 µM -0.799128075832665 0.206560936558875 no 2698 0.212108075733192 3877 786020 SGTC_828 2074-0507 139 µM -0.800112458058059 0.206282871797987 no 2699 0.211822821899432 3902 X828 SGTC_2232 chlorophetanol 41.5365 µM -0.800901398672477 0.206060174925431 no 2700 0.211594365167047 3908 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1055 3448-0672 86 µM -0.804749217821549 0.204976083324889 no 2701 0.210482205753857 3867 748378 SGTC_281 1672-3440 14.9 µM -0.806606218635984 0.204454103834316 no 2702 0.209946694918658 3887 6833000 SGTC_1835 st008666 49.2 µM -0.807375532335836 0.204238091440639 no 2703 0.20972507958667 3776 690455 SGTC_766 1391-0721 126 µM -0.81010441449682 0.203472956748116 no 2704 0.208940083661707 3865 1020919 YIL115C NUP159 SGTC_1882 5615643 20 µM -0.810399441950591 0.203390338340649 no 2705 0.208855319249479 3764 2253075 SGTC_1188 1403-0014 4.57 µM -0.811005915731137 0.203220566518705 no 2706 0.208681136759692 3860 9614867 SGTC_3064 1327-0027 10 µM -0.811020135730658 0.20321658689146 no 2707 0.208677053727921 3716 16000455 YPR107C YTH1 SGTC_2753 fluvastatin 17.09 µM -0.811377851957929 0.203116491274682 no 2708 0.208574357070232 3890 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1901 st060216 58.6 µM -0.812232948193081 0.202877338839946 no 2709 0.20832898849447 3840 688792 SGTC_581 0958-0271 211 µM -0.812433638008717 0.202821234499114 no 2710 0.208271425535524 3864 4591145 SGTC_761 k216-0224 480 µM -0.813378510781668 0.202557212815785 no 2711 0.208000538037589 3855 1340404 SGTC_491 tetrandrine 80.3 µM -0.813555231584934 0.202507855307276 no 2712 0.207949896689647 3846 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2989 9073649 71.4286 µM -0.813911954788 0.202408245660117 no 2713 0.207847695795762 3774 21367202 SGTC_3210 9128157 49.47 µM -0.816072764567001 0.201805498181772 no 2714 0.207229259952793 3932 17590849 SGTC_530 4358-1714 28 µM -0.816208467394435 0.201767680434627 no 2715 0.207190457396956 3905 1564641 SGTC_100 0086-0128 49.5915 µM -0.816431483644023 0.201705539348665 no 2716 0.207126697976065 3909 93297 SGTC_990 3985-0011 41.3 µM -0.820233842869106 0.200647817453998 no 2717 0.206041406256607 3875 5399565 YGL099W LSG1 SGTC_2402 5553605 200 µM -0.821780086430293 0.200218645055427 no 2718 0.205601034630214 3908 6758546 SGTC_1395 3486-0190 4.35 µM -0.822571995713688 0.199999058008865 no 2719 0.20537571463762 3835 6748079 SGTC_2918 7977171 22.06 µM -0.823629995420564 0.199705913301481 no 2720 0.205074913563585 3789 2236483 SGTC_830 4076-0286 57.8 µM -0.823966272616503 0.199612793642831 no 2721 0.204979361086939 3923 6866659 SGTC_2617 dihydrotanshinone i 20.83 µM -0.82446095191776 0.199475857818928 no 2722 0.204838847090786 3874 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1839 st053978 48 µM -0.824812398059005 0.199378605788198 no 2723 0.204739053384675 3879 3788398 SGTC_1632 st005650 90 µM -0.825454377502992 0.199201031219369 no 2724 0.204556836948193 3910 2759605 SGTC_2453 5731132 22.18 µM -0.826937917478468 0.198791041586914 no 2725 0.204136125254199 3903 1362040 SGTC_2481 5478948 45.16 µM -0.827612346438047 0.198604825395745 no 2726 0.203945036932994 3922 77792 SGTC_3304 9125678 46.087 µM -0.828133364654101 0.198461039414277 no 2727 0.203797488019822 3827 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2153 5569715 200 µM -0.831605889703487 0.19750432796093 no 2728 0.202815718280447 3892 2054701 SGTC_2108 5365811 200 µM -0.832383082719411 0.197290586893228 no 2729 0.202596373950538 3922 780283 SGTC_1854 st056233 32.9 µM -0.832397806947892 0.19728653883533 no 2730 0.20259221975468 3781 5393174 SGTC_618 k072-0232 33.2 µM -0.832674581848365 0.197210455856269 no 2731 0.202514141799696 3927 5872756 YGL099W LSG1 SGTC_63 0099-0242 26.702 µM -0.836399000402398 0.196188373577469 no 2732 0.201465237379341 3930 3898502 YLR359W ADE13 SGTC_2463 5473429 200 µM -0.83719878743728 0.195969309824245 no 2733 0.201240419477313 3881 5399405 SGTC_2276 7947513 42.08 µM -0.838003012497885 0.195749180184518 no 2734 0.201014505796937 3817 2105100 SGTC_1186 1319-0216 26 µM -0.838230006874376 0.195687075256204 no 2735 0.200950768680516 3948 4565136 SGTC_1825 st052143 62.6 µM -0.840710466855466 0.19500920918885 no 2736 0.200255077712675 3888 674173 SGTC_1305 1181-0477 144 µM -0.841300363836727 0.194848211093877 no 2737 0.200089843436601 3935 6252086 SGTC_1614 st002383 48.6 µM -0.84131263987674 0.194844861504937 no 2738 0.200086405702551 3883 1947235 SGTC_1480 1070-0044 41.2 µM -0.843650227169334 0.194207675609978 no 2739 0.199432444175432 3899 3124987 SGTC_1202 1988-0068 29.6 µM -0.845096726666214 0.193814021236755 no 2740 0.199028417891894 3846 2850480 SGTC_1640 st009078 66.4 µM -0.845110976712853 0.193810145610669 no 2741 0.199024440121792 3854 690618 SGTC_938 3126-1755 342 µM -0.847107107195439 0.193267719167072 no 2742 0.198467712010086 3938 1777771 SGTC_3277 9138724 49.47 µM -0.847385524280049 0.193192136089744 no 2743 0.198390135195625 3830 15943418 SGTC_1636 st007707 68.9 µM -0.848389468289072 0.192919740979132 no 2744 0.198110552985379 3919 403051 SGTC_474 dl-dihydrosphingosine 5 µM -0.849629631852337 0.192583577644426 no 2745 0.197765516075451 3890 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2912 7964298 10.93 µM -0.85011199410889 0.192452923511176 no 2746 0.19763141193494 3953 2975850 SGTC_2982 9019404 25.97 µM -0.850662667128147 0.192303832780466 no 2747 0.197478383560388 3861 22333232 SGTC_796 1234-0020 70.7 µM -0.85257389389338 0.191786930243518 no 2748 0.196947822432975 3828 46495034 SGTC_2233 sulbentine 40.3845 µM -0.852785510904815 0.191729749534182 no 2749 0.196889130151924 3881 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_913 3487-1245 167 µM -0.85529073271751 0.191053610985762 no 2750 0.196195108334756 3871 4016153 SGTC_1460 k062-0059 9.15 µM -0.855456638460537 0.191008886089587 no 2751 0.196149199884136 3811 1373085 SGTC_2709 st078560 56 µM -0.855913687798642 0.190885707873774 no 2752 0.196022761607018 3876 17250903 SGTC_1421 4029-0249 71.4 µM -0.858043499476331 0.190312350605401 no 2753 0.195434222072916 3975 2894095 SGTC_257 daunorubicin 18.5 µM -0.860242733795015 0.189721415804002 no 2754 0.19482762637179 3953 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1166 k206-0078 225 µM -0.860837037226242 0.189561920221279 no 2755 0.194663901561627 3947 5404595 SGTC_3149 9097855 49.47 µM -0.861266470284851 0.189446722916118 no 2756 0.194545649049201 3942 25236625 YMR079W SEC14 SGTC_1053 3366-3204 134 µM -0.864756071979751 0.188512220173753 no 2757 0.193586343159487 3956 3632071 YPR165W RHO1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.865592894368958 0.188288545433293 no 2758 0.193356726811261 3935 91467 include heat shock SGTC_1260 0700-1617 7.75 µM -0.866606389214866 0.188017867150518 no 2759 0.193078855793319 3952 2853078 SGTC_2316 5844804 197.44 µM -0.867180337538661 0.187864686973061 no 2760 0.192921603925162 3985 776813 SGTC_233 rapamycin 362 pM -0.867186161982887 0.187863132891278 no 2761 0.192920008529681 3919 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2506 ethyl hematommate 54.16 µM -0.867998976409734 0.187646335109074 no 2762 0.192697446498816 4012 3940691 An allergen. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.869258577114793 0.187310673845267 no 2763 0.192352857112491 3919 390807 SGTC_2834 9001755 58.44 µM -0.871874327082406 0.186614809648065 no 2764 0.191638470311389 3878 2989575 SGTC_831 k061-1017 217 µM -0.872086513209091 0.186558432353001 no 2765 0.191580591556746 3986 1240153 SGTC_3087 9117406 49.47 µM -0.872669814532675 0.186403505084112 no 2766 0.191421537593536 3956 42546093 SGTC_2257 7960413 200 µM -0.87272962623411 0.18638762335267 no 2767 0.191405232779828 3917 2974689 YIL048W NEO1 SGTC_2166 5933061 31.504 µM -0.872941856741913 0.186331276797406 no 2768 0.191347385100616 4018 2877375 SGTC_2181 6316240 54.2555 µM -0.87345861243025 0.186194123869681 no 2769 0.191206577792625 3966 12779990 SGTC_509 pifithrin 175 µM -0.874323556038234 0.185964697890303 no 2770 0.190971037272744 3972 4817 A p53 inhibitor. SGTC_1125 tnp00248 1.32998 µM -0.877429381204022 0.185142324523547 no 2771 0.190126730171871 4038 24207736 SGTC_643 k048-0106 28.4 µM -0.877977329094 0.184997471356215 no 2772 0.189978010956837 3962 6763920 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.878100669743805 0.184964875259577 no 2773 0.189944544780662 3727 4000243 SGTC_786 4544-0069 423 µM -0.879410372937643 0.184618971005706 no 2774 0.18958940493679 3960 748821 YLR208W SEC13 SGTC_1506 4226-2149 212 µM -0.879612210983308 0.184565699577767 no 2775 0.189534710771748 3965 991114 SGTC_540 1187-0821 17.3 µM -0.880163259296791 0.18442030922504 no 2776 0.189385436891774 3890 847520 SGTC_1828 st055811 49 µM -0.880166188674058 0.184419536519187 no 2777 0.189384643544033 3973 5877589 SGTC_881 0833-0569 170 µM -0.88037043780307 0.184365665018203 no 2778 0.189329332876982 3950 5418700 SGTC_1043 0916-0009 19.3 µM -0.883125635562111 0.183639927990889 no 2779 0.188584197364943 3966 3101130 SGTC_1550 gossypolone 36.6 µM -0.883362209389401 0.183577696000021 no 2780 0.188520301038004 3951 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1379 2144-0755 36.5 µM -0.884286223165043 0.183334755248851 no 2781 0.18827086168373 4029 5392327 SGTC_691 1548-0686 185 µM -0.886692521124654 0.182703035186778 no 2782 0.187622232991726 3969 46495133 SGTC_1097 itavastatin 7.23 µM -0.887847339583211 0.182400346467687 no 2783 0.18731143724851 3960 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2186 6124449 200 µM -0.892327269323672 0.181229082592149 no 2784 0.186108771017047 3964 3834182 YLR033W RSC58 SGTC_2333 9017922 200 µM -0.892536546699851 0.181174483074958 no 2785 0.18605270641454 4030 3163164 SGTC_15 0266-0086 27.098 µM -0.893260441553027 0.180985701665365 no 2786 0.185858858529575 4032 1712902 YIL048W NEO1 SGTC_834 0312-0008 75.7 µM -0.89350900559281 0.180920908162646 no 2787 0.185792325809901 3950 6385573 YIL048W NEO1 SGTC_1355 1499-0035 1.68 µM -0.893709571779658 0.18086863691991 no 2788 0.185738651365783 3950 1548538 SGTC_2361 9034121 116 µM -0.896635482993279 0.180107167119528 no 2789 0.184956728806796 3962 6496917 SGTC_1263 0774-1208 64.8 µM -0.897134263692699 0.179977560272035 no 2790 0.184823638653119 3978 906585 SGTC_1886 st057356 49.9 µM -0.898605924255056 0.179595494598842 no 2791 0.184431301022003 3932 24207747 SGTC_3233 9132340 49.47 µM -0.898874599571991 0.179525797424819 no 2792 0.184359729440601 3966 17682950 SGTC_720 r052-1644 49.9 µM -0.89897051314132 0.179500920564883 no 2793 0.184334183509489 3992 1422863 YOR257W CDC31 SGTC_2921 7974240 10.71 µM -0.899625959655851 0.179330977063159 no 2794 0.1841596687169 4068 2979074 YDR527W RBA50 SGTC_2771 fluoxetine 41.05 µM -0.899848184029606 0.179273381927723 no 2795 0.184100524096891 3948 3386 A selective serotonin reuptake inhibitor. SGTC_2948 9070189 9.45 µM -0.900132893711712 0.179199609125961 no 2796 0.184024766404956 3908 6473636 YDL196W YDL196W SGTC_1985 st071382 65.5 µM -0.900996311363396 0.178976000674349 no 2797 0.183795140453614 3961 6123237 SGTC_2702 st077768 96.8 µM -0.901777368653778 0.178773873286266 no 2798 0.183587572069645 3964 6484119 SGTC_340 k038-0059 454 µM -0.902828754563186 0.178502015411831 no 2799 0.183308393799939 3963 23733424 SGTC_2109 5483026 200 µM -0.904377674666531 0.178101984315615 no 2800 0.182897586058239 3981 759335 SGTC_2931 9014674 55.67 µM -0.905084162717829 0.177919711347612 no 2801 0.182710400814482 3973 2996810 SGTC_1225 1216-0074 20.6 µM -0.907250350901616 0.177361571386709 no 2802 0.18213721142329 3992 4241466 SGTC_1191 1487-1166 10.6 µM -0.90953406494192 0.176774348200922 no 2803 0.181534142440944 4020 3955771 SGTC_1420 4'-methoxyflavone 42 µM -0.91034757671038 0.176565462947909 no 2804 0.181319617564367 3959 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2667 digitoxin 100 µM -0.910349910367213 0.176564863959944 no 2805 0.18131900240226 3916 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2669 eugenol 100 µM -0.915997847183215 0.175118954323401 no 2806 0.179834012024325 3974 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1428 4049-0204 61.7 µM -0.917317589569869 0.17478217705276 no 2807 0.179488121402294 4051 X1428 SGTC_1092 toremifene 6.32 µM -0.917925202779036 0.174627262128822 no 2808 0.17932901304518 3980 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_250 brefeldin a 552.239 µM -0.918638523115975 0.174445507779952 no 2809 0.179142337646334 3854 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_991 3996-0057 64.7 µM -0.920104647765086 0.174072316004579 no 2810 0.178759037903144 4051 715343 SGTC_1729 st035615 45.989 µM -0.920619586497566 0.173941362470549 no 2811 0.178624536291788 4033 17385451 SGTC_3126 9127922 49.47 µM -0.921199301937253 0.17379401061842 no 2812 0.17847319133334 4053 45595682 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.921290936879879 0.173770726152299 no 2813 0.178449275807844 4018 2374 Ca(2+)-ATPase inhibitor. SGTC_510 ag-490 170 µM -0.921538255088361 0.17370789242773 no 2814 0.17838473905723 4117 5328779 SGTC_1434 4073-0095 163 µM -0.921549959140117 0.17370491925171 no 2815 0.178381685293677 3930 24133745 SGTC_1936 st074407 74.3 µM -0.921953524560581 0.17360242147817 no 2816 0.178276409139647 4044 809813 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.923920605379559 0.17310337228599 no 2817 0.177763827018309 4101 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_138 0850-0259 40.9225 µM -0.926723971434177 0.172393737984501 no 2818 0.177034934060088 3985 6813004 SGTC_3086 9117350 49.47 µM -0.929047196991013 0.171807053004289 no 2819 0.176432313688602 3949 2679265 SGTC_1832 st054113 55 µM -0.929248269556047 0.171756336102731 no 2820 0.176380218657368 4017 1251267 SGTC_3349 9149703 23.001 µM -0.929721220746137 0.171637080460559 no 2821 0.176257722126424 4010 4910494 SGTC_2567 aureobasidin a 60 nM -0.930508227334686 0.17143875237127 no 2822 0.176054003169168 4168 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3071 9117417 49.47 µM -0.931714614252137 0.171135023608333 no 2823 0.175742015903232 3943 45595590 YGL055W OLE1 SGTC_1900 st060200 72.8 µM -0.932113091148492 0.171034775813329 no 2824 0.175639041620842 3983 688945 SGTC_3180 9109287 49.47 µM -0.933379244657554 0.170716489524279 no 2825 0.175312096411352 4060 18891271 SGTC_341 1486-1430 230 µM -0.934812897377105 0.17035655518166 no 2826 0.174942365846703 3992 2054753 YPL210C SRP72 SGTC_3137 9097352 49.47 µM -0.936302764758512 0.1699830229729 no 2827 0.174558662539355 4026 44120435 SGTC_234 nsc-17383 10.7 µM -0.939053441271225 0.169294767508194 no 2828 0.173851653478795 4010 408974 SGTC_161 4065-0411 162.148 µM -0.939544466452579 0.169172094973166 no 2829 0.173725636630381 4038 1906281 YLR208W SEC13 SGTC_1327 1436-0082 2.18 µM -0.941077545759962 0.168789454051469 no 2830 0.173332560750292 4011 15992205 SGTC_1477 0139-0234 16 µM -0.941996954818141 0.168560245930798 no 2831 0.173097099489659 4034 620880 SGTC_886 0866-0150 153 µM -0.942053157153298 0.168546241215426 no 2832 0.173082712645764 4086 271463 SGTC_2331 7980721 200 µM -0.942093371904064 0.168536220807343 no 2833 0.173072418819623 3993 2981221 SGTC_3107 9121808 49.47 µM -0.942428988732838 0.168452609275431 no 2834 0.172986525717977 3903 662681 SGTC_850 0388-0143 75.9 µM -0.944028871368291 0.168054400500845 no 2835 0.172577447409705 3978 67273 SGTC_3039 9090270 49.47 µM -0.944061285935264 0.168046338821998 no 2836 0.172569165622168 4031 17173750 SGTC_629 3448-6466 76.7 µM -0.948407844819547 0.166967580467197 no 2837 0.171460933648389 4031 573744 SGTC_1423 4048-0112 5.59 µM -0.949208698071663 0.166769307630462 no 2838 0.171257239291341 4056 X1423 SGTC_3135 9127742 49.47 µM -0.951254062360648 0.166263612239358 no 2839 0.170737710203514 4111 3643468 SGTC_121 0557-0495 61.343 µM -0.951879644667629 0.166109141398884 no 2840 0.17057901194817 4147 3104427 SGTC_2254 7938975 95.19 µM -0.952270513521113 0.166012673854949 no 2841 0.170479903956683 4119 2969277 SGTC_1993 st073995 70.8 µM -0.952505834150457 0.165954613516419 no 2842 0.170420254274878 4021 3098394 SGTC_2328 6201408 200 µM -0.953775184471458 0.165641654777822 no 2843 0.170098726627254 4045 2890418 SGTC_2524 avocatin b 10.57 µM -0.954374607533583 0.165493999577391 no 2844 0.169947027422918 3997 6710748 SGTC_2134 5324836 1.464 µM -0.954421578176472 0.16548243295066 no 2845 0.169935143976266 3996 699272 SGTC_38 0929-0051 58.268 µM -0.954646406397726 0.165427075736441 no 2846 0.169878270417025 4044 1379719 SGTC_1631 benzylvanillin 81.9 µM -0.9595634518875 0.164219397270403 no 2847 0.168637485348019 4122 75506 SGTC_3248 9135562 49.47 µM -0.961470122713117 0.163752640993351 no 2848 0.168157920472855 4031 17650701 SGTC_1972 st070201 17.4 µM -0.961807826077173 0.163670060488031 no 2849 0.168073073051812 4032 2829099 SGTC_168 3970-0862 530.542 µM -0.962556277056713 0.163487133935202 no 2850 0.167885124169172 4021 3135186 SGTC_1654 st012436 41.8 µM -0.962921591334351 0.163397896859403 no 2851 0.16779343664162 3972 4323132 SGTC_2468 5987765 72.9 µM -0.962929872634918 0.163395874313094 no 2852 0.167791358553052 4094 26772094 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.966326536531956 0.162567676629012 no 2853 0.166940405747838 4055 77254 SGTC_3062 9077494 49.47 µM -0.966573078491698 0.162507669594843 no 2854 0.1668787491002 4036 16459633 SGTC_563 tetrahydrosecaminediol 614 µM -0.970253408798989 0.161613610059231 no 2855 0.165960097345617 4122 334274 A psychoactive constituent of the cannabis plant. SGTC_978 1416-0512 87.4 µM -0.970857954903256 0.16146705537293 no 2856 0.165809508953366 4132 6814003 SGTC_1171 0368-0077 21.4 µM -0.971179045477739 0.161389251513738 no 2857 0.165729563365666 4008 3239779 SGTC_1070 indatraline 8.81 µM -0.972363545344219 0.161102445364176 no 2858 0.165434860489562 4065 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2879 9041815 71.43 µM -0.974681672849206 0.160542113844464 no 2859 0.164859093326178 4067 4942971 SGTC_3328 9140624 29.0385 µM -0.977334202402546 0.159902515293687 no 2860 0.164201862876281 4090 4904392 SGTC_1249 0481-0015 10.2 µM -0.977680666333386 0.159819096451036 no 2861 0.164116143423056 4013 4227577 SGTC_538 2922-0838 53.3 µM -0.979038029568275 0.159492555576568 no 2862 0.163780594671637 4046 777039 SGTC_3183 9108214 49.47 µM -0.979805457076476 0.159308128942371 no 2863 0.163591078944612 3992 4974831 SGTC_3060 1327-0027 12.5 µM -0.985570032996609 0.157927263732153 no 2864 0.162172074675031 3976 16000455 YPR107C YTH1 SGTC_1530 rhein 70.4 µM -0.987633281965941 0.157434941977516 no 2865 0.161666140164169 4129 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_562 3772-2733 112 µM -0.987949786991986 0.157359508525907 no 2866 0.161588620275576 4094 2876874 YIL048W NEO1 SGTC_2886 9058944 51.95 µM -0.989367712458272 0.157021862408209 no 2867 0.161241632848407 3918 4949929 SGTC_2359 9039622 200 µM -0.989527991551712 0.156983725654392 no 2868 0.161202440772916 4029 6463596 SGTC_336 4111-0029 111 µM -0.990290314609411 0.156802422176475 no 2869 0.161016119617518 4076 3131175 SGTC_2751 anetholtrithion 17.25 µM -0.990628368442966 0.156722066869178 no 2870 0.160933540092656 4091 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2084 5306078 60.6385 µM -0.992374105352089 0.156307537099824 no 2871 0.160507532931545 4005 679340 SGTC_672 1441-0018 53.7 µM -0.993384234063827 0.156068009558265 no 2872 0.160261370900363 4067 251141 SGTC_3105 9121040 49.47 µM -0.993662566247794 0.156002052357234 no 2873 0.160193586478661 3942 41448907 SGTC_2211 7117706 200 µM -0.994215043872442 0.155871184534865 no 2874 0.160059092796287 4011 822771 SGTC_1768 st044301 37.178 µM -0.99467378264243 0.15576257606325 no 2875 0.15994747477247 4095 3931349 SGTC_762 1165-0429 115 µM -0.99694915573747 0.155224608983247 no 2876 0.159394595015802 4095 5967793 SGTC_3116 9124943 49.47 µM -0.997915481388405 0.154996511818986 no 2877 0.159160172117552 4067 41905195 YPL160W CDC60 SGTC_532 1548-0774 215 µM -0.998904863025976 0.154763201830721 no 2878 0.158920390119249 4217 5932993 SGTC_2843 9000894 45.46 µM -0.99914577311764 0.154706427016546 no 2879 0.158862040112525 3998 2242070 SGTC_1666 st014829 29 µM -1.00106668541298 0.154254221738159 no 2880 0.158397284948514 4074 3858230 SGTC_3013 9080133 71.4286 µM -1.00189080530152 0.154060482485448 no 2881 0.158198166942642 4177 17050193 SGTC_549 1661-1316 519 µM -1.00407868345798 0.15354692373074 no 2882 0.15767034460567 4120 2857282 SGTC_3114 9122766 49.47 µM -1.00703868603704 0.152853931352529 no 2883 0.156958091912025 4095 17176985 SGTC_673 1082-0474 110 µM -1.00716541514965 0.152824308051132 no 2884 0.156927644955675 4104 3098046 SGTC_2432 5630864 12.22 µM -1.00762370369166 0.152717213542263 no 2885 0.156817572530713 4151 5714970 SGTC_542 3381-0244 89.3 µM -1.00795135472654 0.152640677398762 no 2886 0.156738907970518 4117 1112843 SGTC_1482 3346-2049 8.48 µM -1.00965961591039 0.15224205618192 no 2887 0.156329198419729 4097 3826804 SGTC_435 c-PAF 6.7 µM -1.01242532449002 0.151598147102044 no 2888 0.15566736745422 4099 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3178 9107506 49.47 µM -1.01288366998643 0.151491610758498 no 2889 0.155557864649772 4124 8897194 SGTC_1109 tnp00067 928.257 nM -1.01365521257455 0.15131238834371 no 2890 0.155373651067226 4088 676295 SGTC_2358 9037157 4 µM -1.01544107385155 0.150898089987679 no 2891 0.154947811109663 4109 2388925 SGTC_2994 9053520 71.4286 µM -1.01609988870869 0.150745443689967 no 2892 0.154790911027735 4161 4647384 SGTC_2391 6285546 200 µM -1.01690697840656 0.150558582533409 no 2893 0.154598841647075 4095 846083 SGTC_3287 9117173 37.0625 µM -1.01724637001169 0.150480051110846 no 2894 0.154518121063601 4091 2789709 SGTC_2069 5228469 200 µM -1.01901555311579 0.150071123852612 no 2895 0.154097791390198 4123 2835210 SGTC_2639 lactacystin 53 µM -1.02002606566125 0.149837887703748 no 2896 0.153858049453769 4165 3870 A proteasome inhibitor. SGTC_946 3434-1334 87.4 µM -1.02053103844645 0.149721425706628 no 2897 0.153738338293629 4103 4047976 SGTC_2092 5303694 80.6725 µM -1.02055144405026 0.149716720827017 no 2898 0.153733502144285 4100 1963699 SGTC_1199 1638-0010 4.46 µM -1.02375103029162 0.148980218739001 no 2899 0.152976442764775 4109 3111136 SGTC_584 0986-0246 15.4 µM -1.02393911973568 0.148936998514051 no 2900 0.152932015661647 4199 53315 YDR232W HEM1 SGTC_2425 5628681 7.85 µM -1.02400190243544 0.148922573825696 no 2901 0.152917188166803 4185 5714958 SGTC_3331 9141060 1.957 µM -1.0255428159947 0.148568832623783 no 2902 0.152553566839158 4075 4906567 YPR165W RHO1 SGTC_2670 beta-carotene 100 µM -1.02600834520891 0.148462073584388 no 2903 0.152443825234934 4044 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_7 0192-1582 4.227 µM -1.0261644294653 0.148426290528719 no 2904 0.152407042418325 4164 252616 SGTC_2302 7771753 200 µM -1.02620778693261 0.148416351647561 no 2905 0.152396825842856 4121 2203047 SGTC_1670 st016595 4.04 µM -1.02622900580629 0.148411487783427 no 2906 0.152391826080305 4126 597879 SGTC_2442 5158906 48.48 µM -1.02628986848203 0.148397537220328 no 2907 0.15237748572862 4146 1893835 SGTC_61 0978-8327 98.565 µM -1.02706247310846 0.148220521838113 no 2908 0.152195523901014 4033 6150059 YHR072W ERG7 SGTC_2693 st077581 40.7 µM -1.02799265505483 0.148007590615815 no 2909 0.151976641363049 4162 25238761 SGTC_2976 9009005 19.48 µM -1.02806159103516 0.147991818391038 no 2910 0.151960428258524 4168 2993148 SGTC_2080 5212524 12.4 µM -1.03028366088308 0.147484021926485 no 2911 0.151438433400984 4012 260183 SGTC_1078 idebenone 36.1 µM -1.03104124734072 0.147311162341295 no 2912 0.151260738758145 4169 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3024 9090631 49.47 µM -1.03354742692462 0.146740291670614 no 2913 0.15067389390559 4100 25236383 SGTC_39 0986-0283 58.349 µM -1.0376730895417 0.145803763583796 no 2914 0.149711138742981 4217 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2008 4012253 172 µM -1.0381411943231 0.145697757831308 no 2915 0.149602162706135 4123 603940 SGTC_1702 st027038 51 µM -1.03861769353969 0.145589904324507 no 2916 0.149491286800158 4154 5521182 SGTC_1462 k081-0014 26.5 µM -1.03963118046494 0.145360684568419 no 2917 0.149255642435832 3698 3270634 SGTC_3082 9117008 49.47 µM -1.03976244568535 0.145331014156326 no 2918 0.14922514030346 4188 41448529 SGTC_423 5-fluorouracil 457 µM -1.04182783662024 0.144864701821964 no 2919 0.148745752912059 4073 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2107 5363541 170.161 µM -1.04189922402457 0.144848602408392 no 2920 0.148729201968666 4099 244052 SGTC_1521 st012942 49.4 µM -1.04326440742981 0.14454095564729 no 2921 0.14841292537925 4120 24207259 SGTC_1415 3966-0071 78.1 µM -1.04361770269095 0.144461411624671 no 2922 0.148331149609147 4063 2893185 SGTC_408 cantharidin 100 µM -1.04871383430917 0.143317304883205 no 2923 0.147154922551454 4097 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_380 3970-0968 6 µM -1.0496116048112 0.143116386645113 no 2924 0.146948359699461 4033 2891601 SGTC_2475 5812728 15.03 µM -1.05264945222135 0.14243793768151 no 2925 0.146250841735636 4087 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3257 9139206 32.98 µM -1.05553946960247 0.141794526314125 no 2926 0.145589333962326 4145 4910041 SGTC_3354 9151612 71.43 µM -1.05618903179244 0.141650184095041 no 2927 0.145440930391455 4166 27261949 SGTC_318 1488-0629 67.2 µM -1.05836226175242 0.141167984398069 no 2928 0.144945158763072 4189 3662576 SGTC_2097 5376186 200 µM -1.05848805581752 0.141140107129003 no 2929 0.144916496662159 4126 742755 SGTC_905 2-aminofluorene 215 µM -1.05936702754855 0.140945422049322 no 2930 0.144716329978406 4159 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1311 1190-0148 100 µM -1.06045043543644 0.140705706769897 no 2931 0.144469863740755 4210 1961333 SGTC_3207 9114163 49.47 µM -1.06356881309715 0.140017278166277 no 2932 0.143762038334032 4192 849233 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.06363047379369 0.140003688758496 no 2933 0.143748065904275 4202 23665772 A membrane-active detergent. SGTC_123 0083-0120 66.675 µM -1.06386737673348 0.13995148602976 no 2934 0.143694391776173 4124 16001701 SGTC_284 0988-0104 32.6 µM -1.06399077829999 0.139924299127595 no 2935 0.14366643854686 4140 4666532 SGTC_1030 k029-0042 36.7 µM -1.06540309577583 0.139613403604389 no 2936 0.143346778228123 4140 6080581 SGTC_2154 5570129 200 µM -1.06596189297171 0.139490524548329 no 2937 0.143220434210074 4197 673366 SGTC_14 0354-0009 295 µM -1.06683745658064 0.139298136778741 no 2938 0.143022620616336 4245 1713507 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.0675917721437 0.139132535703211 no 2939 0.142852348344884 4229 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2129 girgensonine 121.053 µM -1.06931677028431 0.138754336474569 no 2940 0.142463478199628 4172 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3100 9120536 49.47 µM -1.06956782829528 0.138699351393501 no 2941 0.142406941380989 4001 16421196 SGTC_249 wiskostatin 11.211 µM -1.07007874558755 0.138587499476431 no 2942 0.142291932625727 4114 2775510 A n-wasp and actin depolymerizer. SGTC_264 promethazine 12.5 mM -1.07149372444619 0.138278047881269 no 2943 0.141973745464314 4044 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_939 1165-0479 45.3 µM -1.07151190886212 0.138274074072594 no 2944 0.141969659461099 4153 1377347 SGTC_1865 st057639 52.2 µM -1.07361684193343 0.137814612735247 no 2945 0.141497222994634 4149 688818 SGTC_1245 0418-0076 17.2 µM -1.07383584400532 0.137766869218453 no 2946 0.141448130874898 4210 6790114 SGTC_770 0389-1121 67.2 µM -1.07488865728428 0.137537508353308 no 2947 0.141212290423121 4261 6753108 SGTC_2286 7945697 125 µM -1.08261365033215 0.135862552719752 no 2948 0.13948997291777 4210 1245733 SGTC_1891 st059073 26.2 µM -1.0835564476826 0.135659093111864 no 2949 0.13928075503248 4257 688754 SGTC_2761 levamisole 97.89 µM -1.08487009979569 0.135375949672051 no 2950 0.138989596274693 4182 26879 An alkaline phosphatase inhibitor. SGTC_3284 9108171 64.8615 µM -1.09000172734029 0.134273766257059 no 2951 0.13785619158437 4166 8687505 SGTC_2839 9003951 25.97 µM -1.09241521174483 0.133757528927848 no 2952 0.137325319899265 4242 2990634 SGTC_1270 0831-1170 17.3 µM -1.09242169878583 0.133756143209633 no 2953 0.137323894889138 4211 6764716 SGTC_525 k781-2675 26.7 µM -1.09404459960839 0.133409780050312 no 2954 0.136967709059819 4141 3651118 YDL195W SEC31 SGTC_1269 0831-0796 3.05 µM -1.09624324197166 0.132941525690711 no 2955 0.136486170291086 4219 927758 SGTC_2534 helenine 20.12 µM -1.0970171765968 0.132776967065843 no 2956 0.136316941774573 4191 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2662 daunorubicin 22.37 µM -1.10092009923854 0.131949242062539 no 2957 0.135465716754654 4075 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_975 1335-0046 28.5 µM -1.10782956855069 0.130492636259044 no 2958 0.133967713808693 4216 16486740 SGTC_1756 st041558 35.5 µM -1.10785189479144 0.130487947693277 no 2959 0.133962891905878 4282 3955792 SGTC_1350 1495-0454 146 µM -1.10785452730748 0.130487394866075 no 2960 0.133962323356913 4239 1069057 SGTC_424 splitomicin 100 mM -1.10869535972318 0.13031090330775 no 2961 0.133780812191267 4259 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2853 9015042 58.44 µM -1.10908447508178 0.130229283528835 no 2962 0.133696870794729 4120 6457456 SGTC_323 4013-0906 34.3 µM -1.11456112278391 0.129084268433937 no 2963 0.132519269021967 4226 2910086 SGTC_787 4152-0075 138 µM -1.1162452746202 0.128733566549647 no 2964 0.132158579801433 4224 9566539 SGTC_179 1273-0063 6.77 µM -1.11643188725374 0.12869474770907 no 2965 0.132118655286544 4167 3108139 SGTC_2728 chlorpromazine 9.18 µM -1.11833802944802 0.128298700428412 no 2966 0.131711325307292 4273 2726 A thorazine and dopamine antagonist. SGTC_631 k072-0230 41.5 µM -1.12109209662503 0.127727972155047 no 2967 0.131124331243308 4224 5773147 SGTC_1520 flindersine 88 µM -1.12410701239488 0.127105213962641 no 2968 0.130483815399792 4286 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3133 9127736 49.47 µM -1.1269703919094 0.126515716143855 no 2969 0.129877499748256 4236 27243420 SGTC_2678 equilin 100 µM -1.13138206799404 0.125611195443885 no 2970 0.128947157831065 4218 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1158 4092-0494 91.8 µM -1.13231583319477 0.125420326711365 no 2971 0.128750837931559 4323 1148199 SGTC_2317 5986382 200 µM -1.13249733665727 0.125383249530089 no 2972 0.128712701735419 4254 877883 SGTC_1644 st010134 20.9 µM -1.1366578714978 0.124535440643057 no 2973 0.127840668605185 4209 3818134 SGTC_1806 st050005 60.3 µM -1.13822138981049 0.124217874659185 no 2974 0.127514024593215 4271 5194765 SGTC_466 geldanamycin 89.2 µM -1.13945530629017 0.123967654303644 no 2975 0.12725664973519 4195 5288382 HSP90 inhibitor. SGTC_1485 3909-9022 254 µM -1.14026708102785 0.123803230657301 no 2976 0.127087523973594 4279 714516 SGTC_2914 7968218 45.32 µM -1.14095951146634 0.123663100702209 no 2977 0.126943386155756 4204 2977111 SGTC_1183 1254-0324 198 µM -1.14113165787106 0.12362827998085 no 2978 0.126907569455972 4309 5799357 SGTC_2292 7671323 168.05 µM -1.14131674942682 0.123590848453907 no 2979 0.12686906724281 4291 937504 SGTC_2787 5284540 71.43 µM -1.14604044720976 0.122638248283109 no 2980 0.125889208339121 4271 736958 SGTC_2180 6301957 200 µM -1.14614915678645 0.122616386266816 no 2981 0.125866720499278 4258 845462 SGTC_1104 tacrolimus 29.8 µM -1.14749116901292 0.122346726374699 no 2982 0.12558934042485 4290 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1856 st057054 55.7 µM -1.15285084158603 0.121273921712282 no 2983 0.124485806081241 4260 1266018 SGTC_2768 sulfasalazine 50.2 µM -1.15391217050063 0.121062270709146 no 2984 0.124268089500639 4228 5384001 An antioxidant and salicylic acid derivative. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.16024444637436 0.11980488375996 no 2985 0.122974647818622 4261 66535 A nucleotide analog. SGTC_93 0109-0045 59.227 µM -1.16342012169847 0.119177775289751 no 2986 0.122329544766409 4371 88733 SGTC_1933 st074711 15.9 µM -1.16762826369543 0.118350357747682 no 2987 0.121478372183817 4238 17250958 SGTC_2769 toremifene 3.73 µM -1.16823661584602 0.118231078515414 no 2988 0.121355667283315 4303 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2029 5175081 200 µM -1.17217167651026 0.117461586606553 no 2989 0.120564068710701 4222 1380876 SGTC_2878 9043973 25.97 µM -1.17259907241921 0.117378224317818 no 2990 0.120478310785201 4299 6465167 SGTC_580 1123-0028 41 µM -1.17588206946978 0.116739282374942 no 2991 0.119821002462721 4296 1677248 YPR107C YTH1 SGTC_2207 7258803 200 µM -1.17609090125314 0.116698722789051 no 2992 0.119779276713555 4259 3666799 SGTC_1935 st074532 41.6 µM -1.17804996045513 0.116318718175959 no 2993 0.119388344660767 4238 2829742 SGTC_578 3460-0051 92 µM -1.1783401954212 0.116262495179819 no 2994 0.119330504667002 4319 2876744 SGTC_1185 1319-0113 81.3 µM -1.18218605683275 0.115519312590518 no 2995 0.118565941936248 4339 4672763 SGTC_1562 morin hydrate 59.1 µM -1.18239997650021 0.115478073615375 no 2996 0.118523516264798 4304 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3091 9116372 49.47 µM -1.18288536962812 0.115384539368365 no 2997 0.118427290344778 4330 17169793 SGTC_973 1325-0077 65.9 µM -1.18337105771673 0.1152910021869 no 2998 0.118331061234783 4279 2835149 SGTC_3246 9135460 32.98 µM -1.1847282344107 0.115029913452955 no 2999 0.118062457664525 4247 41446951 SGTC_2446 5162541 200 µM -1.18613548533144 0.114759635936037 no 3000 0.117784399440234 4236 1549321 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.18722795069576 0.114550128087656 no 3001 0.117568859342524 4322 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1615 st002656 86.5 µM -1.19008457347203 0.11400358545452 no 3002 0.117006576438546 4281 1584458 SGTC_1014 4130-3005 69.3 µM -1.19305584036542 0.113437082386268 no 3003 0.116423752268058 4291 743608 SGTC_137 0438-0332 85.389 µM -1.19468458825166 0.113127397815366 no 3004 0.11610514305953 4236 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_513 4245-1575 41.7 µM -1.20530537363095 0.111122785101927 no 3005 0.114042717959311 4150 719745 SGTC_2239 6685329 187.64 µM -1.20572280527975 0.111044520113916 no 3006 0.113962194370068 4320 805680 SGTC_2179 6298986 200 µM -1.20823252759396 0.110574800038574 no 3007 0.113478916669785 4273 738374 SGTC_1737 st035557 69.7 µM -1.20952700550373 0.110333082813763 no 3008 0.113230221211608 4149 5716916 SGTC_2263 7948595 193.29 µM -1.21038112916318 0.110173800349713 no 3009 0.113066339803989 4306 2971371 SGTC_2050 5263056 171 µM -1.2126521517063 0.109751087977182 no 3010 0.112631420393419 4280 763468 YGL055W OLE1 SGTC_2718 lomofungin 53.02 µM -1.21302210652225 0.109682337577934 no 3011 0.112560684339613 4270 5351222 A RNA synthesis inhibitor. SGTC_822 1487-0950 154 µM -1.2146957894326 0.109371695746388 no 3012 0.112241069526405 4295 1958375 SGTC_2638 epoxomicin 18 µM -1.21536218035129 0.109248187159854 no 3013 0.112113992905103 4271 9915668 A protesome inhibitor. SGTC_1754 st042065 16.137 µM -1.21628980939266 0.109076427697677 no 3014 0.111937271064926 4069 1126236 YIL048W NEO1 SGTC_666 0272-0154 136 µM -1.21733767405716 0.108882638986023 no 3015 0.11173788292691 4298 6870312 SGTC_690 glyoxal 20.3 µM -1.21910287040328 0.108556749177427 no 3016 0.111402575292789 4099 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_625 k213-0058 121 µM -1.22148393253051 0.108118270881205 no 3017 0.110951422743727 4368 3655420 SGTC_1761 st044296 37 µM -1.22261219445149 0.107910944548185 no 3018 0.110738102535303 4292 1826700 SGTC_890 0929-0006 47.2 µM -1.22569026047195 0.107346783949294 no 3019 0.110157628360052 4295 1378169 SGTC_712 r015-0009 80.6 µM -1.22982273571658 0.106592714731427 no 3020 0.109381746196322 4339 6813872 YLR060W FRS1 SGTC_1488 4013-0813 75.9 µM -1.23085401818694 0.106405130115195 no 3021 0.109188733947514 4251 2910057 SGTC_432 NS 1619 61.3 µM -1.23090410862098 0.106396025014347 no 3022 0.109179365382993 4302 4552 A K+/calcium channel activator. SGTC_2419 paclitaxel 166.5 µM -1.23246811271962 0.106112013879934 no 3023 0.108887135511529 4244 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_29 0299-0004 12.984 µM -1.23318554996454 0.105981916192822 no 3024 0.108753272635849 4201 16871 A napthoquinone isolated from Swertia calycina. SGTC_1841 st054148 70 µM -1.23782963734026 0.105142560011821 no 3025 0.107889618320885 4341 675442 SGTC_3332 9141069 11.198 µM -1.23841667124326 0.105036804989946 no 3026 0.107780801102796 4264 17332883 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.23899268191837 0.104933110677873 no 3027 0.107674104104045 4294 6312947 SGTC_1219 1469-0211 33.1 µM -1.24086557260486 0.104596462340938 no 3028 0.107327706325747 4332 6822282 SGTC_2205 7238770 200 µM -1.2416722412494 0.104451706576792 no 3029 0.107178757884496 4381 279867 SGTC_2215 7188065 200 µM -1.24328473627208 0.104162781389112 no 3030 0.106881463426075 4352 940217 SGTC_3015 9080845 49.47 µM -1.24351954932659 0.104120756202818 no 3031 0.106838220800647 4355 5296973 SGTC_3160 9100216 49.47 µM -1.24570127020704 0.103730874754307 no 3032 0.106437043579082 4293 17191039 SGTC_1329 1447-1697 50.6 µM -1.24596798242715 0.103683285061103 no 3033 0.10638807495539 4321 2840515 SGTC_591 4299-0174 154 µM -1.24969289253737 0.10302030093257 no 3034 0.105705877331108 4349 5509088 SGTC_3174 9107204 49.47 µM -1.25065380429725 0.102849772253742 no 3035 0.105530405702144 4358 3938802 SGTC_1315 1237-0019 3.69 µM -1.25101688159986 0.102785391979921 no 3036 0.105464159197145 4328 825140 SGTC_1340 1486-1359 257 µM -1.25729035057425 0.101677611741205 no 3037 0.104324258413196 4258 4309068 SGTC_1608 st001473 40.5 µM -1.25950406315348 0.101288792852583 no 3038 0.10392416177797 4279 7292267 SGTC_2099 5377090 177.372 µM -1.26044901595144 0.101123150633756 no 3039 0.103753714500553 4355 2243829 SGTC_615 k087-0205 167 µM -1.26598163690445 0.100157289576821 no 3040 0.102759828333465 4367 9642773 SGTC_2479 5617353 43.85 µM -1.2704478766781 0.0993825190515588 no 3041 0.101962569203696 4359 2731746 SGTC_1687 st020778 55.3625 µM -1.27345967504837 0.0988625335247086 no 3042 0.10142748659653 4354 4259299 SGTC_271 rotenone 740 µM -1.27415612773015 0.0987425752025413 no 3043 0.101304045011517 4379 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_679 0422-0091 41.4 µM -1.27432708231501 0.0987131459525815 no 3044 0.101273761191738 4370 627384 YHR062C RPP1 SGTC_748 act1.228 77.9 µM -1.27641032333797 0.0983550387175291 no 3045 0.100905254430257 4302 4421505 YNR035C ARC35 SGTC_945 3381-0768 11.3 µM -1.27759384176717 0.0981520172394626 no 3046 0.100696336531724 4359 1126236 YIL048W NEO1 SGTC_1827 berberine 7.24 µM -1.28015045040973 0.097714503263598 no 3047 0.100246114183873 4259 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2128 5255449 168.493 µM -1.28259307689833 0.0972978323627012 no 3048 0.0998173384586768 4285 736008 SGTC_2977 9011197 71.43 µM -1.28333034307178 0.0971723236633852 no 3049 0.0996881832186674 4402 2704722 SGTC_21 0849-0113 22.993 µM -1.28342146723854 0.0971568193706345 no 3050 0.0996722284516616 4319 1560156 SGTC_2890 9046729 58.44 µM -1.28596127121356 0.0967254153940021 no 3051 0.0992282891405613 4316 903329 SGTC_476 mead acid 10 µM -1.28626005318987 0.0966747577557215 no 3052 0.0991761594176879 4408 5312531 An omega 9 fatty acid. SGTC_1127 asiatic acid 681.4 nM -1.28810240652924 0.096362822444409 no 3053 0.0988551588721506 4309 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1357 1503-1303 39.5 µM -1.28834957148714 0.0963210304140485 no 3054 0.0988121522404852 4336 292895 SGTC_1382 3002-2117 298 µM -1.29150428915182 0.0957887827340028 no 3055 0.0982644343904943 4424 1497314 SGTC_1319 1306-0155 43.7 µM -1.29782865209554 0.0947282908979575 no 3056 0.0971731107945616 4406 3122360 SGTC_2127 5253358 187.912 µM -1.29863691551905 0.0945933844282694 no 3057 0.0970342814655924 4272 20612 SGTC_1273 0849-0096 14.1 µM -1.3006370314979 0.0942601559574453 no 3058 0.0966913625925381 4385 5286025 SGTC_3049 9092223 49.47 µM -1.30136758530985 0.0941386584829903 no 3059 0.0965663316968855 4350 8623917 SGTC_1275 0867-0008 21.1 µM -1.30184090338994 0.0940600032544597 no 3060 0.0964853889314743 4342 3422836 SGTC_1673 st016611 27.3 µM -1.30259735709327 0.093934397700491 no 3061 0.0963561302751485 4372 5226799 SGTC_3337 9144342 33.5465 µM -1.30433851492093 0.0936457571408404 no 3062 0.0960590944324201 4362 17682949 SGTC_2384 9036245 200 µM -1.30536746977598 0.0934754902276117 no 3063 0.0958838748937801 4304 6462766 SGTC_1557 sumaresinolic acid 42.3 µM -1.30772210774232 0.0930867156301282 no 3064 0.0954837910028449 4346 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1801 st050089 28.441 µM -1.312136330481 0.0923611052121575 no 3065 0.0947370698575952 4409 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3245 9134821 49.47 µM -1.3130958353636 0.0922039369802995 no 3066 0.0945753285150801 4387 17014901 SGTC_892 0929-0076 29 µM -1.3140391782441 0.092049609192326 no 3067 0.0944165100979751 4346 5751038 SGTC_1771 st048882 4.1505 µM -1.318667542904 0.0912951944448482 no 3068 0.0936401411035875 4411 4580403 SGTC_567 1080-0542 68.4 µM -1.32041187330671 0.0910120644280945 no 3069 0.0933487707712635 4261 5950415 SGTC_3069 9117009 49.47 µM -1.3211318812356 0.0908953868394008 no 3070 0.093228697214109 4370 41904981 SGTC_622 1348-1566 26.3 µM -1.32127396242804 0.0908723756383946 no 3071 0.0932050162491529 4365 7340407 SGTC_2305 7443522 69.23 µM -1.32572283788654 0.0901540290548111 no 3072 0.0924657599229225 4281 5415886 SGTC_230 MPP+ 141.667 µM -1.32750054982701 0.0898681698524415 no 3073 0.0921715790878787 4349 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_304 1310-0298 97 µM -1.32861392541325 0.0896894805107292 no 3074 0.0919876877107972 4148 1550234 SGTC_2780 5215298 71.43 µM -1.33493626656759 0.0886797933132544 no 3075 0.0909486033765526 4401 2834131 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.33530514518041 0.0886211452963527 no 3076 0.0908882476731218 4418 688788 SGTC_2526 patulin 37.61 µM -1.33894786953522 0.0880435390483373 no 3077 0.0902938221784692 4415 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2436 5633522 8.09 µM -1.33991394945693 0.0878908251703882 no 3078 0.0901366612217058 4384 5724242 SGTC_1583 clindamycin 39.6 µM -1.34030558207484 0.0878289738283521 no 3079 0.0900730087230212 4358 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1200 1643-0193 18.4 µM -1.34227401772475 0.0875185863614327 no 3080 0.0897535823342857 4416 5403974 SGTC_1276 0871-0068 94.2 µM -1.34692191948771 0.0867889440900555 no 3081 0.0890026905781305 4423 3414906 SGTC_697 0508-1955 564 µM -1.3491439714359 0.0864417295432027 no 3082 0.0886453634909717 4396 6243113 SGTC_433 pimozide 108 µM -1.35255262430084 0.0859111186555491 no 3083 0.0880992980946149 4326 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1121 fusaric acid 630.51 nM -1.35407346490041 0.08567516360644 no 3084 0.0878564704438499 4382 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1343 1487-0095 224 µM -1.35428451035344 0.0856424587445992 no 3085 0.0878228129870417 4407 4560101 YGL055W OLE1 SGTC_103 0844-0104 51.839 µM -1.35501658772883 0.0855290841171251 no 3086 0.0877061360792674 4237 5375804 SGTC_1770 st043884 66.3 µM -1.35692585041832 0.0852339311771605 no 3087 0.0874023860652603 4419 670149 SGTC_2831 7999036 19.48 µM -1.36062966916555 0.0846635350449535 no 3088 0.086815375328535 4397 2988270 SGTC_1924 st058459 75.1 µM -1.36186457158915 0.0844739951712552 no 3089 0.0866203144131558 4364 688683 SGTC_1844 rapamycin 4 nM -1.36203822530738 0.0844473673583367 no 3090 0.0865929109649295 4261 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.36310791121423 0.0842834821071994 no 3091 0.0864242519246574 4419 616764 SGTC_2647 atorvastatin 60.16 µM -1.36331777040315 0.0842513578676533 no 3092 0.0863911919402555 4383 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2445 5742597 35.57 µM -1.36566441227462 0.083892770831104 no 3093 0.0860221595976045 4420 1774255 SGTC_1116 jasmonic acid  1.58368 µM -1.36813210986569 0.0835169231117363 no 3094 0.0856353637204685 4448 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2968 9090663 33.37 µM -1.37117888782937 0.0830546247320896 no 3095 0.0851595989184539 4361 25236811 SGTC_1448 4255-0083 152 µM -1.37395773607707 0.0826346608543251 no 3096 0.0847274018387793 4437 5399660 SGTC_848 0368-0089 85.6 µM -1.37398935410639 0.082629891674038 no 3097 0.0847224937367182 4402 762535 SGTC_1274 0865-0114 173 µM -1.37478867109847 0.0825093936111955 no 3098 0.0845984856827837 4408 870624 SGTC_2345 9052315 157.45 µM -1.37489486480711 0.0824933947331124 no 3099 0.0845820207737641 4432 6469265 SGTC_3238 9133470 49.47 µM -1.38117963728659 0.0815507002660578 no 3100 0.0836118670534582 4432 3534688 SGTC_864 0469-0573 172 µM -1.38365574054997 0.0811815320823584 no 3101 0.0832319459134515 4401 689425 SGTC_472 calcifediol 10 µM -1.38453558043222 0.0810506587255917 no 3102 0.0830972606012606 4460 5283731 A vitamin D metabolite. SGTC_1762 st045503 25.4615 µM -1.39168401907619 0.0799932477524581 no 3103 0.0820090518537958 4481 4645554 SGTC_2471 5466956 24.79 µM -1.39461023585251 0.0795634174246055 no 3104 0.081566703364757 4425 724419 SGTC_1574 spiramycin 23.7 µM -1.39489000641033 0.079522413792129 no 3105 0.0815245055958323 4398 6419898 An antibiotic and protein synthesis inhibitor. SGTC_737 1950-0117 57.9 µM -1.39505829521588 0.0794977568119131 no 3106 0.0814991305406675 4424 5393513 SGTC_1769 st044406 64.4 µM -1.40170303702895 0.0785288141949984 no 3107 0.0805019716790154 4417 670903 SGTC_3226 9131256 49.47 µM -1.40627293020924 0.0778676414843563 no 3108 0.0798215475708012 4427 17178073 SGTC_2020 4017018 200 µM -1.40733534149683 0.0777145386575451 no 3109 0.0796639871548918 4470 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2411 st077133 39.94 µM -1.40859720923152 0.0775329894182161 no 3110 0.0794771522720783 4419 1403142 YNL221C POP1 SGTC_3101 9120531 49.47 µM -1.40985753619716 0.0773519834982282 no 3111 0.0792908767087027 4428 24824904 SGTC_2009 4012297 12.05 µM -1.41554211801028 0.0765395608081344 no 3112 0.0784548042766867 4418 45595307 SGTC_1704 st028805 70.8 µM -1.4167400326851 0.0763691895629279 no 3113 0.0782794740321185 4481 2876101 SGTC_3025 9087895 49.47 µM -1.42364850851113 0.075392269920289 no 3114 0.0772741231225164 4419 17173641 SGTC_2061 5245884 80.95 µM -1.43197363737151 0.0742277121219093 no 3115 0.0760756830750538 4421 573863 SGTC_840 0245-0196 390 µM -1.43204115160726 0.0742183243967263 no 3116 0.076066022266425 4530 3827528 SGTC_1872 amphotericin b 148 nM -1.43390966884681 0.0739588703276848 no 3117 0.0757990211520244 4460 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1596 piperlongumine 63 µM -1.43808229840675 0.0733819798404373 no 3118 0.0752053522792085 4497 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1755 st041960 45.185 µM -1.44423351580266 0.0725378230983713 no 3119 0.0743366500566022 4475 2257073 SGTC_841 0251-0215 91.2 µM -1.44482117515342 0.0724575670648343 no 3120 0.0742540608252407 4501 3888614 SGTC_769 0302-0231 76 µM -1.44495916166127 0.0724387322547128 no 3121 0.0742346784612596 4374 571869 YER009W NTF2 SGTC_1220 1838-0075 193 µM -1.4461489630085 0.0722764829504261 no 3122 0.0740677125120685 4398 5529645 SGTC_2908 7930301 100 µM -1.45153620300916 0.0715453260425739 no 3123 0.0733153044185618 4421 2223178 SGTC_148 3253-0744 288.01 µM -1.45711141434055 0.0707946474046647 no 3124 0.0725428140480982 4347 6893655 SGTC_316 k060-0003 58.6 µM -1.45841442657953 0.0706200778763125 no 3125 0.0723631732752776 4504 6152314 SGTC_1169 aniline yellow 25.8 µM -1.46045981709211 0.0703467166168047 no 3126 0.0720818716994539 4404 6051 A DNA damaging agent. SGTC_910 3454-3003 490 µM -1.46178366344588 0.0701702221063074 no 3127 0.0719002511055151 4383 820824 SGTC_986 1493-0483 84 µM -1.46196415490639 0.0701461854852157 no 3128 0.0718755164016663 4430 40079 SGTC_2729 fluphenazine 10.66 µM -1.46256028289895 0.0700668422282307 no 3129 0.07179386887869 4421 3372 An atypical antipsychotic. SGTC_2150 5556613 200 µM -1.46437367850551 0.0698259078959112 no 3130 0.0715459379450797 4503 743190 SGTC_641 4092-0595 30 µM -1.47604420353922 0.0682905484157365 no 3131 0.069966013022488 4521 786260 SGTC_782 0083-0095 30.5 µM -1.47641145849686 0.0682426590762731 no 3132 0.0699167342463921 4446 3591729 An indicator and reagent. SGTC_3176 9106582 49.47 µM -1.47645311644643 0.0682372285969548 no 3133 0.0699111462123483 4494 17018027 SGTC_732 3970-1727 52.7 µM -1.47710109473488 0.0681528018748128 no 3134 0.0698242700773992 4553 1275699 SGTC_3282 9108498 15.4605 µM -1.48550505112238 0.0670651201410374 no 3135 0.0687050431789195 4458 16459645 SGTC_444 curcumin 90.4 µM -1.48653294594258 0.0669330115311368 no 3136 0.0685691045652464 4406 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_767 0929-0023 86 µM -1.4871815762775 0.0668497509603881 no 3137 0.068483430325573 4510 1204563 SGTC_1231 0242-0792 125 µM -1.48896346041933 0.0666214341835279 no 3138 0.0682484954600759 4478 3707635 SGTC_586 0957-0265 8.15 µM -1.49093453510392 0.0663695795671457 no 3139 0.0679893416220774 4380 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_873 0591-4978 488 µM -1.49447671630992 0.0659188300413672 no 3140 0.067525531595628 4513 3305145 SGTC_3340 9146634 11.102 µM -1.49769099143806 0.0655118635815998 no 3141 0.0671067767324633 4486 4907387 SGTC_1267 0828-0272 9.49 µM -1.49785121762521 0.0654916280890286 no 3142 0.067085955176094 4548 745334 SGTC_124 0136-0217 7.121 µM -1.50092766429445 0.0651040328611058 no 3143 0.0666871359916584 4533 3976905 SGTC_2543 pimpinellin 60.67 µM -1.50335922122446 0.0647989474108712 no 3144 0.0663732181320404 4353 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1074 carmofur 3.8 µM -1.50554129315561 0.0645261107831551 no 3145 0.0660924844242796 4528 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2582 agaric acid 100 µM -1.50571363390158 0.0645046001409452 no 3146 0.066070351239917 4096 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1492 4158-0558 28.5 µM -1.51292464276522 0.0636095443356752 no 3147 0.065149400774587 4507 3967268 SGTC_923 1900-2434 73.3 µM -1.51671422451371 0.0631430576589547 no 3148 0.0646694256788781 4478 5910570 SGTC_2480 5767542 37.17 µM -1.52023204064696 0.06271241299752 no 3149 0.0642263336572422 4434 2867358 SGTC_1675 st018485 24.5 µM -1.52128688689959 0.0625837277171152 no 3150 0.0640939297495293 4509 3323024 SGTC_2212 7123476 200 µM -1.52215545018729 0.0624779225077374 no 3151 0.0639850673925868 4544 1085715 SGTC_1849 st056239 19.2 µM -1.52746761604998 0.0618338459136224 no 3152 0.0633223869851948 4501 5393181 SGTC_3027 9089541 49.47 µM -1.52955343277786 0.0615823714303509 no 3153 0.0630636517525714 4507 9943819 SGTC_1052 3253-3998 198 µM -1.52981680254057 0.0615506753786268 no 3154 0.0630310406702962 4462 5450317 SGTC_2724 maprotiline 69.64 µM -1.53023416219648 0.0615004730284863 no 3155 0.0629793890883938 4450 4011 A tricyclic antidepressant. SGTC_1612 st002233 45.4 µM -1.53360525591181 0.0610961505930177 no 3156 0.0625633972576977 4533 1035021 SGTC_2946 9065502 71.43 µM -1.53534183957105 0.0608886804537524 no 3157 0.062349940952847 4376 16489101 SGTC_2704 st078022 71.1 µM -1.53558809516398 0.0608593048763272 no 3158 0.0623197178952573 4545 54697681 SGTC_443 clozapine 122 µM -1.53843043428817 0.060521046718347 no 3159 0.0619717028149986 4506 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2348 9022543 33.42 µM -1.54643472824479 0.0595763809301234 no 3160 0.0609998061999472 4522 3162678 YDL140C RPO21 SGTC_803 4488-1585 147 µM -1.54652969620141 0.0595652425916346 no 3161 0.0609883469485393 4516 747204 SGTC_1623 st003709 20.3 µM -1.54778552803816 0.05941810550472 no 3162 0.0608369709694038 4503 16192618 SGTC_331 k048-0133 24.5 µM -1.55061095324255 0.0590881117561455 no 3163 0.060497472823693 4503 6813582 SGTC_2284 7945075 39.21 µM -1.55367794600241 0.058731533275236 no 3164 0.0601306281132152 4480 1245402 SGTC_142 0335-0849 62.6745 µM -1.55374041635129 0.0587242878609139 no 3165 0.0601231741386903 4487 3889043 YPR107C YTH1 SGTC_1609 st001574 46.4 µM -1.55544240312452 0.0585271584275003 no 3166 0.0599203709591151 4514 3960012 SGTC_1575 cyproterone acetate 48 µM -1.55672989233036 0.0583783828742154 no 3167 0.0597673142096612 4513 9880 An androgen receptor antagonist and liver toxin. SGTC_1980 st071811 45.7 µM -1.55707382559548 0.0583386900480417 no 3168 0.0597264792970643 4584 4974850 SGTC_2315 7733312 200 µM -1.55798656941307 0.0582334544127861 no 3169 0.0596182159556788 4438 726316 SGTC_3017 9080681 49.47 µM -1.57103050579422 0.0567457811033334 no 3170 0.0580877815378002 4557 16451914 SGTC_1416 3966-0321 25.3 µM -1.57682041821582 0.0560951036882337 no 3171 0.0574184260473421 4582 582530 YLR208W SEC13 SGTC_815 1582-0027 36.9 µM -1.58071442207261 0.0556608101290354 no 3172 0.0569716746406824 4549 3128206 SGTC_3076 9116187 49.47 µM -1.58092507396657 0.0556373922496588 no 3173 0.05694758521656 4535 27241210 SGTC_1977 st070720 65.3 µM -1.58571380449953 0.055107130542383 no 3174 0.0564021231226499 4557 682188 SGTC_18 0111-0177 500 nM -1.58999670917642 0.0546362691175704 no 3175 0.0559177734101004 4609 721752 SGTC_319 1348-1596 45.5 µM -1.59064341106205 0.0545654481392917 no 3176 0.0558449244709188 4594 5380505 SGTC_3230 9131665 49.47 µM -1.59586165313514 0.0539966461501404 no 3177 0.055259842327585 4573 15943720 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.60436959265135 0.0530793347063626 no 3178 0.0543163047075702 4548 641818 YHR062C RPP1 SGTC_3044 9093193 49.47 µM -1.60521140859406 0.0529892474373332 no 3179 0.0542236438038649 4546 25236277 SGTC_652 0437-0092 114 µM -1.61744930872727 0.0516932516879814 no 3180 0.0528906646923568 4521 3091274 SGTC_3093 9117344 49.47 µM -1.61863554212766 0.0515689806994534 no 3181 0.0527628515626667 4568 24824913 SGTC_1971 st069429 63.5 µM -1.62458647824576 0.0509491357072583 no 3182 0.0521253501109917 4555 1246522 YGL099W LSG1 SGTC_2671 danthron 100 µM -1.62570591057885 0.0508332019466511 no 3183 0.0520061160493051 4550 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3034 9090421 49.47 µM -1.63040540348196 0.0503487900770301 no 3184 0.0515079216985756 4498 17173761 SGTC_3266 9136860 49.47 µM -1.6305240544651 0.0503366076113249 no 3185 0.0514953927717052 4315 4871271 YPR165W RHO1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.63154391309432 0.0502319906811784 no 3186 0.0513878009209381 4457 4330530 SGTC_2910 7948405 25.97 µM -1.64143963576395 0.04922586486391 no 3187 0.0503530939568924 4521 2971328 SGTC_1909 st060837 51.5 µM -1.65187023266462 0.0481828454900315 no 3188 0.0492805037410526 4511 678937 SGTC_211 3455-0679 143.504 µM -1.65472735980422 0.0479002503085334 no 3189 0.0489899073000808 4547 748649 SGTC_118 0083-0097 135.343 µM -1.65645644087937 0.0477298743427967 no 3190 0.0488147096458407 4551 5207356 SGTC_1597 7-benzyloxygramine 47.5 µM -1.65853717611301 0.0475254916748337 no 3191 0.0486045451505797 4471 260807 SGTC_144 4161-2749 112.381 µM -1.66345584787455 0.0470451364835137 no 3192 0.0481106109360689 4577 797501 YMR168C CEP3 SGTC_623 k072-0108 16.9 µM -1.66727635572322 0.0466747200858921 no 3193 0.0477297329579988 4548 5382803 SGTC_2312 7706453 155.7 µM -1.66779713383747 0.0466244099004412 no 3194 0.0476780025300869 4556 976098 SGTC_3280 9140961 49.47 µM -1.66816429299394 0.0465889663582774 no 3195 0.0476415585215706 4597 4901226 SGTC_2909 7941780 10.49 µM -1.67677753221274 0.0457636771767317 no 3196 0.046792996406378 4526 1243215 SGTC_554 4483-2211 187 µM -1.68369318211666 0.0451095843222145 no 3197 0.0461204898258694 4627 747107 SGTC_406 estrone 100 µM -1.68508275102875 0.0449790688183823 no 3198 0.0459863035374658 4575 5870 A steroid. SGTC_3216 9129716 49.47 µM -1.68740560179711 0.0447615735345272 no 3199 0.0457626937170734 4494 8056934 SGTC_307 1501-1223 22.3 µM -1.68826825839373 0.0446810164609283 no 3200 0.0456798727324678 4599 2830329 SGTC_936 3005-4620 401 µM -1.68948842732044 0.0445672733909426 no 3201 0.0455629338827864 4585 777207 SGTC_210 3551-0445 56.827 µM -1.69883430622347 0.0437037749320522 no 3202 0.0446752038578143 4569 2865180 YOR207C RET1 SGTC_1997 st073024 93.8 µM -1.70510902751854 0.0431316427408879 no 3203 0.0440870461345259 4643 686268 SGTC_2935 9038016 29.96 µM -1.71188845638387 0.0425203063755073 no 3204 0.043458613206203 4550 6463195 SGTC_3081 9117243 49.47 µM -1.71531419008453 0.0422140658226869 no 3205 0.0431438191569473 4556 45595589 SGTC_3200 9114385 49.47 µM -1.7155554269792 0.0421925680928573 no 3206 0.0431217212566141 4560 17018030 YLR208W SEC13 SGTC_744 1594-0068 283 µM -1.72172588196073 0.0416456952993155 no 3207 0.0425595932623508 4589 668392 SGTC_165 k038-0023 64.381 µM -1.7284825509765 0.0410534684882262 no 3208 0.0419508733516969 4559 46368543 SGTC_3190 9110366 49.47 µM -1.72972024091511 0.0409457277997276 no 3209 0.0418401352750029 4598 17123768 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.7327446409573 0.0406834191029583 no 3210 0.0415705331224308 4624 804 An inhibitor of viral and cellular DNA polymerases. SGTC_916 4466-0038 42 nM -1.74148234768621 0.0399332443915619 no 3211 0.0407995324196612 4637 5722064 YGL116W CDC20 SGTC_1012 4112-3522 18 µM -1.74564962274565 0.0395794438458037 no 3212 0.0404359269487276 4604 3112398 SGTC_1949 st076024 69.1 µM -1.75330961632644 0.0389357641650621 no 3213 0.0397744378790507 4573 2921930 SGTC_2978 9011784 42.97 µM -1.76141266337812 0.0382641588777643 no 3214 0.0390842916224529 4591 2994934 SGTC_1917 st066507 28.5 µM -1.76282660672498 0.038147940566922 no 3215 0.0389648692427835 4542 3156428 SGTC_2045 5106652 78.05 µM -1.76392204313889 0.0380580998150125 no 3216 0.0388725525312591 4613 673349 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.76975893137159 0.0375823008722294 no 3217 0.0383836540212537 4632 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1491 4138-0063 26.5 µM -1.77226307715402 0.0373796675179898 no 3218 0.0381754486432589 4639 23883227 SGTC_2970 9090938 41.86 µM -1.78211223952984 0.0365913221865399 no 3219 0.0373654651272395 4634 17217104 SGTC_829 1635-0120 117 µM -1.78601719516852 0.0362825514455371 no 3220 0.0370482370194782 4596 285054 SGTC_355 1311-2252 105 µM -1.78612031949666 0.0362744262455401 no 3221 0.0370398894034335 4584 5338538 SGTC_2314 7727897 200 µM -1.78909643128357 0.0360405784718627 no 3222 0.0367996434070739 4597 900724 SGTC_1318 1280-3875 124 µM -1.79010322172366 0.0359617500232337 no 3223 0.0367186594917921 4636 373245 SGTC_859 0439-0102 54.6 µM -1.79746748656184 0.0353894369575351 no 3224 0.0361307176495611 4656 610143 SGTC_2861 9024595 19.48 µM -1.80007374242498 0.0351886902090236 no 3225 0.0359244975231822 4593 16482810 SGTC_479 n-linoleoylglycine 10 µM -1.80187838163851 0.0350502360897422 no 3226 0.0357822710949978 4653 6433346 An anti-infammatory. SGTC_86 0417-1630 471.922 µM -1.82431982893372 0.0333655528428577 no 3227 0.0340518671864544 4649 3634867 SGTC_2616 abietic acid 100 µM -1.82918224830127 0.0330094607595006 no 3228 0.0336861554214622 4656 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1539 benzyladenosine 56 µM -1.8307303555804 0.0328967468519996 no 3229 0.0335703999430729 4660 92208 A nucleotide analog. SGTC_2752 diclazuril 33.15 µM -1.83485780408565 0.0325977869876391 no 3230 0.0332633805941113 4551 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_639 0833-0042 114 µM -1.83599175930555 0.0325160457085033 no 3231 0.0331794377177691 4652 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1686 st019653 115.5 µM -1.83713137580604 0.0324340667581101 no 3232 0.0330952516466689 4637 97252 SGTC_3319 9138450 16.7555 µM -1.8408413382949 0.0321683688930987 no 3233 0.0328224064833917 4594 2029690 SGTC_893 0958-0369 48.9 µM -1.841701863818 0.0321069976870281 no 3234 0.03275938571922 4504 6819948 SGTC_971 1315-0384 26.7 µM -1.84321079780239 0.0319996164732852 no 3235 0.032649119486572 4661 6769120 SGTC_3213 9129884 49.47 µM -1.84937528787433 0.031564005190163 no 3236 0.0322018206186251 4597 17190742 SGTC_1932 st074806 40.9 µM -1.85125722330951 0.0314319996453549 no 3237 0.0320662784614946 4650 17251235 SGTC_2135 5326629 150.42 µM -1.86750211659826 0.0303113951777613 no 3238 0.0309157507604924 4620 5020077 SGTC_1045 1348-1485 165 µM -1.8732259311943 0.0299245287376622 no 3239 0.0305185964741771 4629 6810614 SGTC_311 1315-0136 58 µM -1.87908082052454 0.0295330490148714 no 3240 0.030116729270347 4666 6759207 SGTC_610 4215-0184 155 µM -1.88814683561455 0.0289352559677623 no 3241 0.0295031203656459 4667 5605015 SGTC_3080 9117754 49.47 µM -1.90347261010225 0.0279475921500664 no 3242 0.0284894521792997 4651 9550191 SGTC_2347 9049783 174.81 µM -1.90612871501113 0.0277793084975643 no 3243 0.0283167539959498 4629 6467988 YPL169C MEX67 SGTC_1820 st053765 18.6 µM -1.91199172995762 0.0274108310465009 no 3244 0.0279386274057723 4683 3690829 SGTC_3271 9137798 49.47 µM -1.91468865330266 0.0272427090438014 no 3245 0.0277661107427275 4667 6498326 SGTC_1763 st044482 94.5 µM -1.91932032042479 0.0269559855535528 no 3246 0.0274719039465997 4649 88505 SGTC_153 4077-0274 519.67 µM -1.9344309194571 0.0260380230285546 no 3247 0.0265300839710182 4650 3121976 SGTC_576 1073-0113 22.7 µM -1.93682190880743 0.0258951953145673 no 3248 0.0263835584194197 4702 5439563 SGTC_62 0180-0423 3.232 µM -1.9553281623432 0.024811732486177 no 3249 0.025272174602045 4627 30102 YGL099W LSG1 SGTC_2730 imipramine 71.33 µM -1.95532868273736 0.0248117025623285 no 3250 0.0252721439103108 4646 3696 A tricyclic antidepressant. SGTC_3323 9138564 53.9225 µM -1.96004800308103 0.0245415729315159 no 3251 0.0249950899348027 4694 43912313 YNL103W MET4 SGTC_877 0771-0151 33.1 µM -1.96911443912184 0.0240295415953005 no 3252 0.0244699755575571 4681 6166523 SGTC_598 3937-0236 20.2 µM -1.98103735285696 0.0233698798958384 no 3253 0.023793542422365 4726 1379313 SGTC_1377 2944-0135 198 µM -1.98927962211618 0.0229228219092656 no 3254 0.0233351738234728 4672 1894137 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.9892901760119 0.0229222541205112 no 3255 0.0233345916988257 4699 5106787 A p450 inhibitor. SGTC_3286 9117135 37.221 µM -2.00159183014046 0.0222684440292328 no 3256 0.022664324200474 4631 3438150 SGTC_2025 5147754 141 µM -2.01933129921426 0.0213533766346642 no 3257 0.0217263984133576 4686 315777 YLR208W SEC13 SGTC_2595 hexamethylquercetagetin 100 µM -2.02395699630587 0.0211200607036053 no 3258 0.0214872883289645 4650 386331 SGTC_2749 bexarotene 57.39 µM -2.03257253437686 0.0206912483677204 no 3259 0.0210478643534735 4669 82146 An retinoic acid receptor inhibitor. SGTC_1242 0402-0103 60.1 µM -2.04935544338624 0.0198770790469544 no 3260 0.0202136854085246 4630 432868 SGTC_2508 celastrol 40.54 µM -2.04938490290414 0.0198756741668884 no 3261 0.0202122461623884 4655 122724 Celastrol is a natural product and antioxidant. SGTC_922 1866-0035 480 µM -2.05367498037764 0.019671984455946 no 3262 0.0200035798368533 4632 3156169 SGTC_2429 5902844 64.44 µM -2.05507584782358 0.0196058573255157 no 3263 0.0199358396580417 4691 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1494 4358-1428 177 µM -2.05905255870888 0.0194191666233911 no 3264 0.0197446019165597 4728 1564571 SGTC_3144 9087057 49.47 µM -2.0671887801489 0.0190419060290779 no 3265 0.0193581845077176 4640 17249618 SGTC_1773 st048542 73.5835 µM -2.08124860735184 0.0184046673298601 no 3266 0.0187055782667457 4693 3237138 SGTC_1162 k048-0130 20.1 µM -2.08842751777029 0.0180863605928421 no 3267 0.0183796436895766 4708 6797406 SGTC_73 0327-0325 16.231 µM -2.09343000842314 0.01786733917632 no 3268 0.0181553929868616 4545 53298 SGTC_181 1447-1644 8.07 µM -2.09956597506048 0.0176017841864445 no 3269 0.0178835192422486 4673 534600 SGTC_1222 0366-0074 1.18 µM -2.10084383004824 0.0175469064975156 no 3270 0.0178273387522882 4718 286520 SGTC_1885 st057546 99.9 µM -2.10159574512957 0.0175146836883072 no 3271 0.0177943514521471 4712 702008 SGTC_2820 7989630 71.43 µM -2.10893472038197 0.0172028209960286 no 3272 0.0174751083719527 4726 2984098 SGTC_1229 0139-0193 12.2 µM -2.11251785317891 0.0170522909202931 no 3273 0.0173210281534801 4744 3090752 SGTC_1156 4092-0367 4.88 µM -2.11834766960271 0.0168097822184127 no 3274 0.0170728171277554 4729 1357585 SGTC_3253 9135987 49.47 µM -2.12135232047479 0.0166859508449603 no 3275 0.0169460822359997 4708 4182430 SGTC_2545 solidagenone 89.61 µM -2.12802504891559 0.0164137348221685 no 3276 0.0166675033980278 4712 6708572 An anti ulcer agent SGTC_3208 9114115 49.47 µM -2.14016091829699 0.0159283884753001 no 3277 0.0161708821768884 4664 650895 SGTC_409 arachidonic acid 100 µM -2.14742439007793 0.0156438293253898 no 3278 0.0158797553220348 4719 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2443 5493264 126.67 µM -2.15084341313788 0.0155114000408851 no 3279 0.0157442805958716 4722 5340055 SGTC_2688 kanamycin b 96.69 µM -2.15223325014228 0.0154578430923136 no 3280 0.0156894940352988 4653 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2794 7785382 27.27 µM -2.15571376813302 0.0153244184449565 no 3281 0.0155530112114011 4697 2205081 SGTC_2949 9072542 2.23 µM -2.15899885564334 0.0151993940422605 no 3282 0.0154251278573915 4671 16457352 SGTC_3040 9091894 49.47 µM -2.15906165113774 0.0151970127213484 no 3283 0.0154226921457339 4666 25236966 SGTC_1515 3460-0031 42.1 µM -2.16008107344986 0.0151583991602428 no 3284 0.0153831969603214 4703 2876596 SGTC_2747 doxorubicin 7.63 µM -2.16394096847833 0.0150129573796092 no 3285 0.0152344400963456 4766 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3278 9139605 49.47 µM -2.16524988302727 0.0149639102542997 no 3286 0.0151842770545964 4689 7958859 SGTC_1689 st020265 53.493 µM -2.16805067619837 0.0148594225839164 no 3287 0.0150774155241209 4717 5758320 YPR016C TIF6 SGTC_953 1188-0045 9.7 µM -2.16862499887062 0.0148380743270353 no 3288 0.0150555828335512 4684 6144426 SGTC_1081 sertraline 6 µM -2.2075948657231 0.0134498157954413 no 3289 0.013636263687405 4709 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2644 guaiazulene 100 µM -2.20954359612874 0.0133834411068159 no 3290 0.0135684267787705 4747 3515 A coloring agent. SGTC_2722 naftopidil 47.16 µM -2.22092992438564 0.0130012450326042 no 3291 0.0131778540251978 4698 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_438 sphingosine 6.67 µM -2.22880216711652 0.0127425535588865 no 3292 0.0129135353498932 4696 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1800 st050079 29.0735 µM -2.23067160904912 0.0126817798725543 no 3293 0.0128514447887042 4595 3645560 SGTC_504 lovastatin 124 µM -2.24910328593361 0.0120958903386164 no 3294 0.0122529627747549 4715 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2708 st078559 56 µM -2.24996000568925 0.0120692379798742 no 3295 0.0122257421176599 4719 17250902 SGTC_800 3448-7362 155 µM -2.25003984931181 0.0120667566584329 no 3296 0.0122232079084623 4769 15991913 SGTC_1020 4335-0961 93.3 µM -2.25310678169626 0.0119717789857499 no 3297 0.0121262084901295 4702 669075 SGTC_1516 st013856 110 µM -2.26457683652001 0.0116222945965497 no 3298 0.0117693298482487 4728 5281404 A mutagen and neurotoxin. SGTC_2852 9023854 51.95 µM -2.27119865118733 0.0114245930347034 no 3299 0.0115674775248785 4721 19798528 SGTC_3021 9087658 49.47 µM -2.27664823681165 0.0112640877573318 no 3300 0.0114036199563889 4753 25237042 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.30628119180016 0.0104251839970696 no 3301 0.010547462691662 4693 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1984 st072354 53.1 µM -2.311519153975 0.0102827031843726 no 3302 0.0104020982154673 4686 5762938 SGTC_2944 9067346 25.62 µM -2.32041387382861 0.0100446408684991 no 3303 0.0101592495412116 4668 6473075 SGTC_1807 st050092 58.9 µM -2.3205742304108 0.0100403935249572 no 3304 0.010154917169538 4742 5008496 SGTC_2030 5175110 200 µM -2.32618526459749 0.00989275846843264 no 3305 0.0100043347098174 4753 2831986 SGTC_1146 3579-1023 7 µM -2.33844034735963 0.00957688418808403 no 3306 0.00968220838366849 4744 X1146 SGTC_2958 9077254 16.72 µM -2.36409502954356 0.00894405634544445 no 3307 0.0090370878656432 4733 16457351 SGTC_2014 4013930 200 µM -2.38797381189498 0.00838826493390022 no 3308 0.0084707744730667 4723 64556 SGTC_1351 1496-0003 46.5 µM -2.4161854243846 0.00777088663044102 no 3309 0.00784203602073592 4767 3891978 SGTC_473 2-arachidonoylglycerol 10 µM -2.43733167881597 0.00733470153931873 no 3310 0.00739805043545068 4670 5282280 An endocannabinoid. SGTC_44 0929-0055 61.211 µM -2.44952133828408 0.00709319569555541 no 3311 0.00715231168689598 4619 1379590 SGTC_517 1365-0151 113 µM -2.45278153330422 0.00702980461724795 no 3312 0.00708782013100274 4722 768657 SGTC_1588 farnesol 29.9 µM -2.45621990792177 0.00696349126017425 no 3313 0.0070203603763994 4765 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1160 4092-0570 10.5 µM -2.51578815152325 0.00589913479349332 no 3314 0.0059383273764645 4761 4994975 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.5187978739086 0.00584940905656601 no 3315 0.0058878116578347 4723 88881 An O-methylated flavonoid and antioxidant. SGTC_574 1315-0397 40 µM -2.52816305364891 0.0056970506281443 no 3316 0.00573305436060275 4759 6794277 SGTC_3199 9111318 49.47 µM -2.52892837575032 0.00568475701431929 no 3317 0.00572056862706451 4711 8548020 SGTC_221 trifluoperazine 10.304 µM -2.5386902266921 0.00553000273407755 no 3318 0.00556341473846144 4737 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2959 9079155 11 µM -2.54148786392396 0.0054863474174106 no 3319 0.00551908890922389 4747 16189457 SGTC_1096 rimcazole 32.2 µM -2.55281621641518 0.005312690256266 no 3320 0.00534279315862553 4764 18528119 A dopamine reuptake inhibitor. SGTC_2019 4016004 108 µM -2.56793857799578 0.00508849766016429 no 3321 0.00511526408632544 4744 45595336 SGTC_1969 st069479 40.1 µM -2.57747259201605 0.00495152039782871 no 3322 0.00497628870008925 4771 3895485 SGTC_1140 3229-1848 2.98 µM -2.57944110776283 0.00492365091064507 no 3323 0.00494801653866758 4763 2849525 SGTC_654 1124-0271 80.9 µM -2.6053125503104 0.00457014796243231 no 3324 0.00458952422672778 4777 5403748 SGTC_166 k072-0058 166.424 µM -2.62094109253933 0.00436774745084448 no 3325 0.00438437061147812 4692 5846229 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.78474121264371 0.00268118921853241 no 3326 0.00267852296750221 4766 551469 SGTC_2600 tangeritin 87.95 µM -2.82324532143042 0.00238222554943884 no 3327 0.00237700897446718 4764 68077 A bioactive flavone. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.8342827367255 0.00230227501869355 no 3328 0.0022964338306459 4754 6728940 SGTC_2641 levomentholum 100 µM -2.85243741837905 0.00217604174354442 no 3329 0.00216926771348158 4790 16666 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.86529291885745 0.00209048560693135 no 3330 0.00208311832322676 4758 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_663 1486-0733 13.9 µM -2.87478104342272 0.00202931007584916 no 3331 0.00202153884148831 4789 722445 YPR165W RHO1 SGTC_158 k038-0087 26.446 µM -2.8977998350631 0.00188759040166583 no 3332 0.00187895171302269 4745 X158 SGTC_2716 st080858 38.6235 µM -2.91876496643213 0.00176640527546971 no 3333 0.00175710537672552 4781 5296050 SGTC_2699 st077704 54.6 µM -2.97608667304978 0.00147032609668097 no 3334 0.00145976168352661 4778 645852 SGTC_2807 7945238 51.95 µM -2.99529532583473 0.00138173043835253 no 3335 0.00137089619285161 4764 17148797 SGTC_349 k015-0014 24 µM -3.00217871692782 0.00135118823617881 no 3336 0.00134027378313298 4786 2196908 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -3.02160361177423 0.00126829505675152 no 3337 0.00125719785973242 4802 165521 SGTC_2812 7970281 58.44 µM -3.02824408688122 0.00124104227156167 no 3338 0.00122989659341669 4782 2233435 SGTC_1003 4049-0218 100 µM -3.12319517748845 0.000905697529236429 yes 3339 0.000894495346706851 4787 295161 SGTC_2795 7780010 54.55 µM -3.12483829614685 0.000900708620922012 yes 3340 0.000889514133375376 4773 953673 SGTC_2679 rapamycin 1 nM -3.14987850631108 0.000827740537366822 yes 3341 0.000816691862559909 4702 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2624 nerol 100 µM -3.27260472845865 0.000542576948427011 yes 3342 0.000532806931998127 4773 637566 A natural product oil. SGTC_2439 5492030 7.2 µM -3.31379176031626 0.000469413098876342 yes 3343 0.000460200132727518 4798 5722370 SGTC_2555 cholic acid 100 µM -3.32214112420253 0.000455743404395746 yes 3344 0.000446647504188004 4783 6708657 Influences liver metabolism. SGTC_2809 7964133 12.99 µM -3.32354713845563 0.000453478078996083 yes 3345 0.000444402000304512 4788 1253665 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -3.3336771461798 0.000437462822804166 yes 3346 0.000428530381607137 4802 688803 SGTC_1307 1187-1599 12.2 µM -3.43303176053094 0.000305923490949859 yes 3347 0.000298436087674242 4804 1538471 SGTC_2804 7954240 19.48 µM -3.44588693276628 0.000291894939790342 yes 3348 0.000284594228770272 4788 828705 SGTC_2748 diazoxide 86.69 µM -3.47521615078806 0.00026210001714456 yes 3349 0.000255220937231904 4809 3019 A potassium channel activatior. SGTC_1164 k060-0068 93.7 µM -3.58123532817799 0.000176425174328905 yes 3350 0.000170986728007972 4798 5963676 SGTC_1148 3909-7663 27.7 µM -3.60173437978961 0.000163230306399351 yes 3351 0.000158050626624003 4805 4084526 SGTC_58 0957-0393 9 µM -3.87073926186135 5.67647731652525e-05 yes 3352 5.42529003450109e-05 4605 6997992 SGTC_3214 9129694 49.47 µM -4.07445673717853 2.43897686436389e-05 yes 3353 2.30609429278134e-05 4803 17158655 SGTC_1150 3909-7983 10.9 µM -4.25552858849991 1.11420434799342e-05 yes 3354 1.04277856419748e-05 4808 23965914 SGTC_354 2783-3500 4.88 µM -4.63511182528656 1.95116211555969e-06 yes 3355 1.78372287227577e-06 4810 6740761 SGTC_2802 7925815 54.55 µM -5.56882078894339 1.5036857861876e-08 yes 3356 1.282345502339e-08 4810 1262923