SGTCid condition conc unit HTA1|YDR225W.score HTA1|YDR225W.strain.pval HTA1|YDR225W.strain.significant HTA1|YDR225W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1915 st067105 30.6 µM 29.2925333951031 7.16826528440365e-183 yes 1 6.45524505263464e-189 1 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2671 danthron 100 µM 16.4632442230256 3.07542252370659e-59 yes 2 3.36948733417162e-61 1 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2544 sphondin 68.51 µM 13.3021980218145 2.23501413339594e-39 yes 3 1.1238116159377e-40 1 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_580 1123-0028 41 µM 10.90938202889 4.01939473397346e-27 yes 4 5.19803177902768e-28 1 1677248 YPR107C YTH1
SGTC_1213 1315-0166 115 µM 10.2918347497493 2.39272084071164e-24 yes 5 3.83503617948366e-25 2 768401
SGTC_546 peri-Naphthalide 147 µM 9.91605601512115 9.76177319553326e-23 yes 6 1.77243859170385e-23 1 223824 A penicillin ester.
SGTC_93 0109-0045 59.227 µM 8.91541272809806 9.81138315362574e-19 yes 7 2.43001324438304e-19 1 88733
SGTC_2166 5933061 31.504 µM 8.3549163275142 1.12625936669743e-16 yes 8 3.27395547098008e-17 4 2877375
SGTC_2532 xanthone 78.9 µM 8.06046105136819 1.20661101974827e-15 yes 9 3.80036139419131e-16 1 7020 An insecticide.
SGTC_1547 harmine 94.2 µM 8.03022698744647 1.53208590119017e-15 yes 10 4.86462450455403e-16 11 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_744 1594-0068 283 µM 7.54621318183033 6.22450540981974e-14 yes 11 2.24048174614971e-14 3 668392
SGTC_3247 9135149 49.47 µM 7.05219494828706 2.16888163976175e-12 yes 12 8.8058607543492e-13 8 8934436 YOR116C RPO31
SGTC_605 1315-0399 119 µM 6.92424966916827 5.23836700099296e-12 yes 13 2.19146164466517e-12 4 24020461
SGTC_2194 5927483 104.545 µM 6.90330439400834 6.04289389165887e-12 yes 14 2.54032997266851e-12 5 760979
SGTC_1525 8-methoxypsoralen 92.5 µM 6.55321527557732 6.18849901192217e-11 yes 15 2.81556229803441e-11 9 4114 Related to psoralen; DNA damaging agent.
SGTC_2692 st077426 47.7 µM 6.18065488992415 6.47672996418857e-10 yes 16 3.19181146884642e-10 3 25238571
SGTC_672 1441-0018 53.7 µM 6.07916791885039 1.20021452205056e-09 yes 17 6.04038982742845e-10 1 251141
SGTC_315 k915-0449 187 µM 5.86354449581994 4.30950720542246e-09 yes 18 2.26544678762553e-09 22 20970215 YNL149C PGA2
SGTC_1309 pyrazolanthrone 13.4 µM 5.70021264214309 1.10224007743076e-08 yes 19 5.98290377821747e-09 9 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_829 1635-0120 117 µM 5.30016253376391 9.88859342317054e-08 yes 20 5.78498174622487e-08 16 285054
SGTC_343 4130-2827 29.8 µM 5.28821431556043 1.0533881917648e-07 yes 21 6.17581054271996e-08 11 1118244
SGTC_3108 9121785 49.47 µM 5.26665925491952 1.18023692974465e-07 yes 22 6.94643646836934e-08 2 17140271
SGTC_116 0155-0182 31.788 µM 5.0878902174385 2.98001376654542e-07 yes 23 1.810344254136e-07 39 771486
SGTC_2800 7887935 81.82 µM 5.07221107186187 3.22758289568634e-07 yes 24 1.96609943929344e-07 7 2961002
SGTC_905 2-aminofluorene 215 µM 4.95106953355423 5.93326630572407e-07 yes 25 3.69033623084382e-07 12 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1114 scopoletin 1.73284 µM 4.55138613551697 4.01285039050556e-06 yes 26 2.66468185827971e-06 13 5280460 A coumarin with genotoxic properties.
SGTC_151 3013-0144 2.285 µM 4.42732119278616 7.04685084977745e-06 yes 27 4.7705303141449e-06 16 906558 YHR107C CDC12
SGTC_71 0417-1750 47.813 µM 4.40322864992498 7.84807533876863e-06 yes 28 5.3325828495945e-06 33 6811472
SGTC_2283 7944793 200 µM 4.40023940509746 7.95333943398936e-06 yes 29 5.40657569694691e-06 27 2970533
SGTC_2682 pyrogallin 40.03 µM 4.35434684018597 9.74838608847034e-06 yes 30 6.67321267828039e-06 19 822798 An ATP competetive kinase inhibitor.
SGTC_632 0781-2353 4.65 µM 4.256125256496 1.49707677391789e-05 yes 31 1.04000103613011e-05 32 6811515 YHR007C ERG11
SGTC_1853 st056710 91.2 µM 4.25008394502032 1.53665637758835e-05 yes 32 1.0684520747497e-05 21 269167
SGTC_2229 7354935 190 µM 4.24578143950267 1.56544832253011e-05 yes 33 1.08916445355113e-05 6 318112
SGTC_698 k064-0052 127 µM 4.14226336475571 2.43425538443089e-05 yes 34 1.71947557925352e-05 2 5088751
SGTC_2611 pyromycin 23.93 µM 4.12234261388531 2.64708452673158e-05 yes 35 1.87519420120412e-05 22 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1168 k815-0004 80.5 µM 4.11544053231008 2.72485249245285e-05 yes 36 1.93220312252042e-05 14 642433
SGTC_574 1315-0397 40 µM 4.11481293376134 2.73203020555482e-05 yes 37 1.93746768797941e-05 30 6794277
SGTC_1353 1498-1206 8.11 µM 4.10172839076798 2.88581842801514e-05 yes 38 2.05037733174016e-05 47 6756808
SGTC_3320 9137005 35.139 µM 4.09841752104201 2.9260127421447e-05 yes 39 2.0799220781992e-05 12 4908713
SGTC_9 0092-0002 10.449 µM 4.04093904655214 3.71418904088187e-05 yes 40 2.66187977875413e-05 26 759368
SGTC_1243 0416-0003 5.65 µM 4.02132285180541 4.02636602979731e-05 yes 41 2.89361108630649e-05 28 2141977
SGTC_1327 1436-0082 2.18 µM 3.97375011222801 4.88960511480582e-05 yes 42 3.5374895099604e-05 20 15992205
SGTC_3058 9093861 49.47 µM 3.86061088318603 7.69601921675926e-05 yes 43 5.65519497014332e-05 18 17217477
SGTC_1693 xanthone 101.9 µM 3.84634022160413 8.14235899831959e-05 yes 44 5.99476266448116e-05 18 7020 An insecticide.
SGTC_1117 retinoic acid 1.10837 µM 3.77371185536945 0.000108168098309635 yes 45 8.04182577875947e-05 17 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2764 methyldopa 94.69 µM 3.75972130963696 0.000114187494487683 yes 46 8.50513716866516e-05 19 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2378 9074213 121.43 µM 3.71702343648641 0.000134559804980905 yes 47 0.000100791874994141 25 657714
SGTC_2012 4023501 200 µM 3.67459251395096 0.00015814209090988 yes 48 0.000119114657114798 37 3477460
SGTC_3200 9114385 49.47 µM 3.67327076348224 0.000158935398385882 yes 49 0.000119732752667965 47 17018030 YLR208W SEC13
SGTC_3234 9132280 49.47 µM 3.66523059300005 0.00016384188232912 yes 50 0.000123557912808156 28 17612295
SGTC_1438 4092-1045 4 µM 3.66323579915752 0.000165080957701605 yes 51 0.000124524539463467 11 1351342
SGTC_450 aminopyrene 156 nM 3.59567967473013 0.000212605957556665 yes 52 0.000161772862507339 42 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1071 trifluoperazine 6.31 µM 3.49976527504308 0.000302319980312624 yes 53 0.000232834003606712 39 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3323 9138564 53.9225 µM 3.45058307994282 0.000360953922234362 yes 54 0.000279688484363954 36 43912313 YNL103W MET4
SGTC_29 0299-0004 12.984 µM 3.4408204459084 0.000373782865543425 yes 55 0.000289976625116851 46 16871 A napthoquinone isolated from Swertia calycina.
SGTC_313 3474-0040 5.03 µM 3.42594985788547 0.000394140010213686 yes 56 0.000306326735475624 94 1043375 YIL048W NEO1
SGTC_2681 menadione 3.18 µM 3.4240058623327 0.000396876027510523 yes 57 0.000308526449103348 41 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2336 9001819 198.65 µM 3.40150935646497 0.000429846517842489 yes 58 0.000335074172479937 75 2989602
SGTC_381 3461-2219 42.7 µM 3.37013814615449 0.000480076885178195 yes 59 0.000375652541227417 36 2883159
SGTC_2481 5478948 45.16 µM 3.30972844769719 0.000592437893630054 yes 60 0.000466932620076973 65 77792
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 3.28687249702809 0.000640948603445231 yes 61 0.000506533457306585 61 6710655
SGTC_1765 st044815 90.4 µM 3.28560663956111 0.00064373962806117 yes 62 0.000508815068556631 48 645695
SGTC_146 3448-8650 53.125 µM 3.27616570300579 0.000664911956801453 yes 63 0.000526134016515116 200 2891488 YIL048W NEO1
SGTC_838 0109-0203 71.4 µM 3.27019862734749 0.000678623217195052 yes 64 0.000537359958869743 40 759422
SGTC_372 0155-0182 15.9 µM 3.24883623798537 0.000729876547966589 yes 65 0.00057939084208714 55 771486
SGTC_2156 5649887 115 µM 3.24327273950471 0.000743798095663153 yes 66 0.000590825184358156 37 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2214 7179297 48.276 µM 3.2432668014842 0.000743813084206648 yes 67 0.000590837499052033 14 769744
SGTC_1933 st074711 15.9 µM 3.23933046146978 0.000753810521756369 yes 68 0.000599053354142794 77 17250958
SGTC_2211 7117706 200 µM 3.2315055676509 0.000774052605484123 yes 69 0.000615699624730656 27 822771
SGTC_110 0850-0284 111.64 µM 3.22305451687374 0.00079647588708737 yes 70 0.000634157060545005 24 3906265
SGTC_314 1671-0008 2.74 µM 3.21356831299437 0.000822357149156687 yes 71 0.00065548304314263 94 3913060
SGTC_1267 0828-0272 9.49 µM 3.20732231517519 0.000839818304272927 yes 72 0.000669883979462678 49 745334
SGTC_3344 9148862 3.898 µM 3.19460681392561 0.000876423955410843 yes 73 0.000700107298580697 36 4905352
SGTC_2834 9001755 58.44 µM 3.16994642086436 0.000951630178075042 yes 74 0.000762335244828413 71 2989575
SGTC_20 0481-0013 4.944 µM 3.16012385095068 0.000983202661261162 yes 75 0.000788510436539051 61 182045
SGTC_158 k038-0087 26.446 µM 3.1466650651572 0.00102802534958272 no 76 0.000825720083533697 200 X158
SGTC_16 erodoxin 22.806 µM 3.13600502475807 0.00106484928330886 no 77 0.000856331346436489 106 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2977 9011197 71.43 µM 3.12017258639482 0.00112177676129408 no 78 0.000903725534431691 39 2704722
SGTC_2594 a-mangostin 100 µM 3.11358236397801 0.00114628423100064 no 79 0.000924154566247445 67 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3011 9081274 71.4286 µM 3.08130221832292 0.00127356317764951 no 80 0.00103048672965111 49 6625322
SGTC_712 r015-0009 80.6 µM 3.07805308455309 0.00128706547776915 no 81 0.00104178897814723 53 6813872 YLR060W FRS1
SGTC_1303 1160-0052 261 µM 3.06809029196611 0.00132928764911789 no 82 0.00107715757310573 34 3562476
SGTC_2983 9022671 12.99 µM 3.04659328546131 0.00142473637667156 no 83 0.00115725323962517 40 6405161
SGTC_17 0960-0276 49.807 µM 3.04547729217632 0.0014298582858166 no 84 0.00116155660142823 87 6821114
SGTC_1790 st045711 43.5 µM 3.02330636826784 0.00153516063184644 no 85 0.00125014488800268 42 585119
SGTC_2112 5488546 200 µM 3.02025580536615 0.00155019036620741 no 86 0.00126280638380793 57 600757
SGTC_172 1112-0046 2.638 µM 3.01522303110485 0.00157527971112496 no 87 0.00128395175611776 76 2802135 YIL048W NEO1
SGTC_2128 5255449 168.493 µM 2.9938699888829 0.0016858978780472 no 88 0.00137731648111506 85 736008
SGTC_3278 9139605 49.47 µM 2.97848011576892 0.00176996062150243 no 89 0.00144840912413801 55 7958859
SGTC_141 0443-0274 32.331 µM 2.94912007192589 0.00194098773243303 no 90 0.00159340067915817 111 1627241
SGTC_91 0417-1751 58.384 µM 2.93691375630734 0.0020164080211296 no 91 0.00165748139798464 116 6795624
SGTC_3238 9133470 49.47 µM 2.93247737339186 0.00204447207785865 no 92 0.00168134712336177 41 3534688
SGTC_1362 1611-0397 101 µM 2.89304961107151 0.00230990206984347 no 93 0.00190760514704792 64 27816
SGTC_165 k038-0023 64.381 µM 2.88903968629303 0.00233857460445783 no 94 0.00193210150809652 154 46368543
SGTC_1261 0712-0010 12.7 µM 2.8611463150443 0.00254710426059863 no 95 0.00211056097003222 82 2840123
SGTC_2696 st077691 74.316 µM 2.84751499973292 0.00265500398558649 no 96 0.00220310088559901 90 757133
SGTC_3277 9138724 49.47 µM 2.8445091731752 0.0026793454130899 no 97 0.00222399525281383 56 15943418
SGTC_2646 retinol 96.75 µM 2.83953978409225 0.00272003021813485 no 98 0.00225893305397204 56 445354 A vitamin A analog and teratogen.
SGTC_2179 6298986 200 µM 2.82961745863762 0.00280293775922214 no 99 0.00233018448745406 65 738374
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.80899518649193 0.00298258444749185 no 100 0.00248481948111853 83 2333 A French combination drug.
SGTC_575 k072-0246 11.9 µM 2.79893654428855 0.00307391804292247 no 101 0.00256356060612057 82 6796779
SGTC_1102 cgs 12066b 26.1 µM 2.79009004729897 0.00315631864164947 no 102 0.00263466920213387 45 6438352 A 5-HT1B full agonist.
SGTC_2376 9072922 81.32 µM 2.77892477967078 0.0032631529959547 no 103 0.00272695764420306 103 17087968
SGTC_2795 7780010 54.55 µM 2.73969156346959 0.00366482746535938 no 104 0.00307484328182635 96 953673
SGTC_1519 esterone 74 µM 2.7013941292992 0.00409914780354186 no 105 0.00345247298593308 90 698 A steroid.
SGTC_884 0851-0618 334 µM 2.69056795872374 0.00423000483319343 no 106 0.00356652525760346 92 9642473
SGTC_1761 st044296 37 µM 2.68587601722829 0.00428786801098272 no 107 0.00361699632203607 74 1826700
SGTC_579 4491-1009 110 µM 2.66648882784756 0.00453453353927676 no 108 0.0038324076969078 108 1271041
SGTC_2757 clomiphene 4.22 µM 2.65832130898096 0.00464218858809124 no 109 0.00392654914976088 137 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_122 0236-0016 402.397 µM 2.64618919076283 0.00480631185701089 no 110 0.00407021370900203 142 6808838
SGTC_3232 9132874 49.47 µM 2.63867733677237 0.0049105069081146 no 111 0.00416150782508658 82 3784940
SGTC_2622 2-methoxyxanthone 59.94 µM 2.63614814425982 0.00494603895782977 no 112 0.00419265568181861 86 71034 A hepatoprotective.
SGTC_680 0417-1641 114 µM 2.62692429659382 0.00507757153999221 no 113 0.00430802501529592 77 2835990
SGTC_2584 androsterone 48.74 µM 2.62438531439616 0.0051143199923117 no 114 0.00434027604724856 267 2754130 A steroid.
SGTC_1120 ficusin 1.78878 µM 2.59852990352088 0.00550224092606595 no 115 0.00468119450229844 101 6199 A DNA cross-linker.
SGTC_650 1328-0195 38 µM 2.59145678183481 0.00561281867625165 no 116 0.00477852724022741 115 2780821
SGTC_472 calcifediol 10 µM 2.57838274345741 0.00582241746763384 no 117 0.00496319911167905 51 5283731 A vitamin D metabolite.
SGTC_2234 tolnaftate 200 µM 2.5741852339506 0.0058911679714323 no 118 0.00502382322138237 25 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1419 3993-2473 62.6 µM 2.52236588748215 0.00680114534785807 no 119 0.00582841950587526 97 704026
SGTC_1679 SEC14.276 6.7 µM 2.51968249155649 0.0068514793497481 no 120 0.00587303673105861 173 1005053 YMR079W SEC14
SGTC_2057 5236571 38.335 µM 2.50476526527491 0.00713733331422829 no 121 0.00612663420294307 159 54684039 YBR257W POP4
SGTC_1800 st050079 29.0735 µM 2.50187354102465 0.00719394824355447 no 122 0.00617690214375359 307 3645560
SGTC_2351 9026858 72.31 µM 2.47192008248252 0.00780408930381192 no 123 0.00671947776487733 125 1409300
SGTC_220 paclitaxel 373.376 µM 2.46383911241752 0.00797630494673796 no 124 0.00687288984967293 72 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.46080109402794 0.00804190805522127 no 125 0.00693135986152016 161 6728940
SGTC_3324 9138759 60.749 µM 2.44133721045862 0.0084735760248169 no 126 0.00731649197206893 111 45595710
SGTC_694 1315-0438 43.2 µM 2.44007641206355 0.00850222640352371 no 127 0.00734207776853604 89 6793154
SGTC_2142 5622915 118.518 µM 2.43719759660484 0.00856796343972878 no 128 0.00740079434882742 91 5322196
SGTC_1910 st062352 60.4 µM 2.43601068774279 0.00859519576274084 no 129 0.00742512287297914 157 2245730
SGTC_1272 0839-0021 27 µM 2.413161968347 0.00913443639998435 no 130 0.00790739498580682 132 5027250
SGTC_543 3844-1095 191 µM 2.38924268829148 0.00973045261635547 no 131 0.00844157285394989 181 4230703
SGTC_317 4495-0002 170 µM 2.38907669739065 0.00973470474161954 no 132 0.00844538789881884 107 15991618
SGTC_839 0122-0028 230 µM 2.38550871813166 0.00982649758868642 no 133 0.00852775906113371 182 759448
SGTC_1400 3771-8998 51.5 µM 2.36761779936791 0.0102982621904057 no 134 0.00895150985217742 65 670767
SGTC_2011 4012611 177 µM 2.36655552186265 0.0103268842534052 no 135 0.00897724049285094 158 2049887
SGTC_1838 st055369 84.5 µM 2.36454051092456 0.0103813674256275 no 136 0.00902622643872503 124 676036
SGTC_780 0109-0199 192 µM 2.3415573740079 0.0110207475292852 no 137 0.00960173706961957 157 610414
SGTC_2600 tangeritin 87.95 µM 2.33344742807439 0.0112544007048726 no 138 0.00981233724720772 139 68077 A bioactive flavone.
SGTC_1053 3366-3204 134 µM 2.32640404893973 0.0114608072221196 no 139 0.00999850291643079 153 3632071 YPR165W RHO1
SGTC_1385 3091-4834 14.1 µM 2.31784306927671 0.0117161079512796 no 140 0.010228925715207 126 4072814
SGTC_2 0422-0095 29 µM 2.31501241101489 0.0118016012452857 no 141 0.0103061264327552 66 6790840
SGTC_1850 st056238 17 µM 2.31260981436665 0.0118745901677672 no 142 0.0103720507219119 146 5393177
SGTC_163 TUB2.036 7.546 µM 2.30289547110507 0.0121737109018792 no 143 0.0106423625210978 325 15992207 YJR013W GPI14
SGTC_3186 9110464 49.47 µM 2.2802183809107 0.0128975035790716 no 144 0.0112973698553179 122 17018021
SGTC_1336 1486-0901 104 µM 2.27496959466659 0.0130702390181009 no 145 0.0114538769315062 151 5006114
SGTC_2025 5147754 141 µM 2.27325418956167 0.0131271241845877 no 146 0.0115054332139455 108 315777 YLR208W SEC13
SGTC_659 k018-0002 107 µM 2.2726837373926 0.0131460885015968 no 147 0.0115226226823505 149 6797879 YHR007C ERG11
SGTC_1903 st060211 78.3 µM 2.26715874322288 0.0133309917807986 no 148 0.011690265059145 174 688960
SGTC_517 1365-0151 113 µM 2.26709523195661 0.0133331302853962 no 149 0.0116922043965874 168 768657
SGTC_2104 5389443 200 µM 2.26181424151261 0.0135119876022288 no 150 0.0118544412911521 172 2244536
SGTC_2255 7941087 197.44 µM 2.25417645412692 0.0137743273495226 no 151 0.0120925347223093 185 935561
SGTC_2718 lomofungin 53.02 µM 2.23961911555849 0.0142865199541593 no 152 0.0125578303214982 119 5351222 A RNA synthesis inhibitor.
SGTC_1094 duloxetine 25.4 µM 2.23269298235114 0.0145359170811358 no 153 0.0127845987783056 175 60834 A selective serotonin reuptake inhibitor.
SGTC_642 0335-0876 158 µM 2.23074502454249 0.0146067310007675 no 154 0.012849011687486 179 6812350
SGTC_1653 st012112 65 µM 2.23026295836363 0.0146243012583381 no 155 0.0128649953783682 131 720429
SGTC_607 4491-0986 66.8 µM 2.22966824615603 0.0146460022712037 no 156 0.0128847377236499 168 698981 YDR232W HEM1
SGTC_582 0987-0078 156 µM 2.22811127191279 0.0147029474334639 no 157 0.0129365479068988 287 1625765
SGTC_590 k048-0076 22.4 µM 2.22098547732622 0.0149660050027823 no 158 0.0131759725213746 141 6832814
SGTC_576 1073-0113 22.7 µM 2.22013912538544 0.0149975163249202 no 159 0.0132046625146546 273 5439563
SGTC_1075 aripiprazole 15.2 µM 2.21987803355635 0.0150072487824553 no 160 0.0132135240019118 205 60795 An atypical antipschotic. YIL048W NEO1
SGTC_629 3448-6466 76.7 µM 2.21633849312653 0.0151397252464812 no 161 0.013334164321668 173 573744
SGTC_331 k048-0133 24.5 µM 2.20197725869043 0.0156875903420266 no 162 0.0138334574498302 126 6813582
SGTC_1218 1348-1416 30.7 µM 2.19891969803126 0.0158064040787502 no 163 0.0139418163554002 169 6787668
SGTC_1091 telmisartan 47.6 µM 2.1936019309481 0.0160148858269501 no 164 0.0141320197433251 156 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_67 0335-0847 266 µM 2.17740703575527 0.0166643815476316 no 165 0.0147251055997608 331 4552207 YOR254C SEC63
SGTC_3235 9132602 49.47 µM 2.16646407659575 0.0171158979991845 no 166 0.0151378710495118 191 4912240
SGTC_1050 3232-1156 69.3 µM 2.15668153296503 0.0175283453056052 no 167 0.015515243423375 187 700529
SGTC_1647 st011722 22.4 µM 2.154580745221 0.0176180160542212 no 168 0.0155973285635191 137 2854783
SGTC_909 3448-9333 149 µM 2.1515793728371 0.0177468067472704 no 169 0.0157152490890969 151 3344074
SGTC_1501 4491-0275 38.4 µM 2.15111941716691 0.0177666145317843 no 170 0.0157333876390449 147 5104718
SGTC_2054 5233173 129 µM 2.13327124736639 0.0185499377071129 no 171 0.0164512407247002 266 6889
SGTC_560 2332-1943 155 µM 2.12985121712176 0.0187033465583254 no 172 0.0165919493442079 141 21177716
SGTC_2381 9035592 200 µM 2.12848635922965 0.018764869364117 no 173 0.0166483898715658 167 4749657
SGTC_3250 9135583 49.47 µM 2.11948834112156 0.019174792423506 no 174 0.0170246090151189 134 7699353
SGTC_2137 5261020 140 µM 2.11216677112069 0.0195139353778368 no 175 0.0173360737663189 200 763655
SGTC_2071 5230951 39.92 µM 2.11199751880653 0.0195218351932306 no 176 0.0173433310569082 191 1799272
SGTC_3073 9114972 49.47 µM 2.10164476511682 0.0200102392486081 no 177 0.0177922027033096 165 41905075
SGTC_2279 7948423 32.93 µM 2.10017977648142 0.020080182133102 no 178 0.0178565148391537 145 1247112
SGTC_2277 7947813 106.88 µM 2.09682933022642 0.020240922069594 no 179 0.0180043431006937 216 1246798
SGTC_3350 9150499 3.57 µM 2.08010856581275 0.0210595115588012 no 180 0.0187577880520514 260 4910996 YPR165W RHO1
SGTC_2525 harmine 47.85 µM 2.07324428121943 0.0214035827645327 no 181 0.0190747756304672 139 5280953 A monoamine oxidase inhibitor
SGTC_33 0986-0033 35.816 µM 2.0726549875193 0.0214333412832891 no 182 0.0191021998383454 163 2848082
SGTC_1812 st052057 4.327 µM 2.0669160179052 0.0217249846671518 no 183 0.0193710340627168 212 3645418
SGTC_2649 anisomycin 9.56 µM 2.06246395563306 0.0219535326591906 no 184 0.0195817928919974 138 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3133 9127736 49.47 µM 2.06042280450296 0.0220589925770303 no 185 0.0196790693330955 190 27243420
SGTC_2299 7976368 114.88 µM 2.05077561228916 0.0225632374180999 no 186 0.0201444017901634 194 2979718
SGTC_1809 st050081 57.6 µM 2.04838972906595 0.0226894323061664 no 187 0.0202609135630789 194 5036894
SGTC_974 1326-0144 138 µM 2.04613970413067 0.0228089858628598 no 188 0.0203713138030554 247 5411856
SGTC_2360 9040895 200 µM 2.0458351344367 0.0228252096838199 no 189 0.0203862969968636 194 4914414
SGTC_2724 maprotiline 69.64 µM 2.03965719507125 0.0231564009784063 no 190 0.0206922405519688 177 4011 A tricyclic antidepressant.
SGTC_925 2064-1272 59.6 µM 2.02496682823641 0.0239602119094511 no 191 0.0214353852677218 208 6815817
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.01977230771556 0.0242499949151756 no 192 0.021703505419907 206 688669
SGTC_1854 st056233 32.9 µM 2.01684031203074 0.0244148556656579 no 193 0.0218560902918749 201 5393174
SGTC_992 3909-8734 162 µM 2.01653164182068 0.0244322662392164 no 194 0.0218722064719314 198 4288319
SGTC_749 1000-0129 128 µM 2.01081683629235 0.0247564978690273 no 195 0.0221724035544482 230 708470
SGTC_1953 st076800 12.1 µM 2.00402403720665 0.0251465770739016 no 196 0.0225337428012393 271 297591
SGTC_3205 9113483 49.47 µM 2.00140606673035 0.0252982840917154 no 197 0.0226743237128181 261 17018033
SGTC_3002 9075603 71.4286 µM 2.00065369555916 0.0253420243301379 no 198 0.0227148613569004 230 20105405
SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.00061117176207 0.0253444984059441 no 199 0.0227171543551726 211 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1113 artemisinin 1.17947 µM 1.99655472368476 0.0255814385271664 no 200 0.022936787719895 197 2240 An anti-malaria and mitochondrial poison.
SGTC_1482 3346-2049 8.48 µM 1.99592912246315 0.0256181449113059 no 201 0.022970819124042 208 3826804
SGTC_2900 5328528 85.29 µM 1.98878646128565 0.0260403664035407 no 202 0.0233623888869789 259 795359
SGTC_525 k781-2675 26.7 µM 1.98627215215008 0.0261903721725112 no 203 0.0235015565226626 267 3651118 YDL195W SEC31
SGTC_2750 bromebric acid 70.15 µM 1.97976799551642 0.026581770647839 no 204 0.0238648020765504 257 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_86 0417-1630 471.922 µM 1.97587980431232 0.0268180742060913 no 205 0.0240841960225065 391 3634867
SGTC_253 dyclonine 31.25 µM 1.97551990464158 0.0268400354086936 no 206 0.0241045890249636 247 3180 An oral anasthetic.
SGTC_2030 5175110 200 µM 1.97151176377821 0.0270856299185814 no 207 0.0243326843920646 208 2831986
SGTC_1429 4049-0205 9.46 µM 1.96717252800336 0.0273536231168812 no 208 0.0245816620098457 226 22774478
SGTC_3118 9124250 49.47 µM 1.96676640300984 0.0273788183672297 no 209 0.0246050737596664 190 1504786
SGTC_1266 0828-0227 32.9 µM 1.96462597624522 0.0275119265176249 no 210 0.0247287715936984 228 3913820
SGTC_96 0929-0093 37.281 µM 1.96376232328465 0.0275657876353811 no 211 0.0247788306407022 215 6991579
SGTC_2188 6126565 140.678 µM 1.95489747790212 0.0281237361484791 no 212 0.0252975861594272 169 874518
SGTC_1417 3966-0327 90.4 µM 1.95311769480496 0.0282368806485811 no 213 0.0254028253532016 250 651118
SGTC_2488 5268135 45.7 µM 1.95058127310931 0.028398780774255 no 214 0.0255534383484486 316 1270356 YLR208W SEC13
SGTC_1173 0443-0020 122 µM 1.94244501292367 0.0289233404092827 no 215 0.0260416252698439 259 5331295
SGTC_736 0958-0254 92.6 µM 1.94186893253283 0.0289607846785473 no 216 0.0260764846364459 275 6812352
SGTC_1476 4112-3294 3.34 µM 1.93931361852835 0.0291273618613307 no 217 0.0262315808044238 207 704369
SGTC_678 1218-2179 85.9 µM 1.92791758262489 0.0298799726992176 no 218 0.0269326891881141 146 6820081 YOR116C RPO31
SGTC_1638 st008370 60.6 µM 1.92739530842133 0.029914847457957 no 219 0.0269651919333907 271 24207134
SGTC_2543 pimpinellin 60.67 µM 1.92671063699707 0.0299606173917779 no 220 0.0270078507507656 233 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2736 butenafine 14.65 µM 1.91780382511657 0.0305613429717118 no 221 0.0275679452884889 283 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1975 st070967 30.8 µM 1.90881882388244 0.031177415900891 no 222 0.0281427338426307 285 261391
SGTC_1569 carminic acid 40.6 µM 1.89753115017841 0.0319658994281472 no 223 0.0288789357838877 253 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1652 st011932 78 µM 1.89507942930824 0.032139319836514 no 224 0.0290409397300533 221 1551076
SGTC_2309 7664088 163.95 µM 1.89248678963187 0.0323235522106698 no 225 0.029213076059181 305 704922
SGTC_1319 1306-0155 43.7 µM 1.89140948314625 0.0324003612380201 no 226 0.0292848518271973 296 3122360
SGTC_1028 k015-0029 4.8 µM 1.8874655851851 0.0326828362864975 no 227 0.0295488654961385 305 4588309
SGTC_2862 9027634 71.43 µM 1.88612699561672 0.0327791708901067 no 228 0.0296389216416542 257 5012562
SGTC_230 MPP+ 141.667 µM 1.87790427937615 0.033376085401976 no 229 0.0301971304352843 244 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1898 st060199 18.6 µM 1.87655345020383 0.0334749973874633 no 230 0.0302896612237952 228 688866
SGTC_2124 5246320 200 µM 1.87609481292581 0.033508635087758 no 231 0.030321130918794 258 579342
SGTC_866 0495-0101 262 µM 1.87217889792524 0.0337969733807301 no 232 0.030590928746798 232 635694
SGTC_1192 1488-0095 21.4 µM 1.87002688145395 0.0339562987379095 no 233 0.0307400425080106 229 915875
SGTC_1855 st056195 39.6 µM 1.85347697852621 0.0352023271201094 no 234 0.0319070114305078 267 4028379
SGTC_717 1532-0246 73.2 µM 1.85264502043628 0.035265941927676 no 235 0.0319666275542432 279 9561992
SGTC_2974 9094440 9.66 µM 1.85022241172448 0.035451721445927 no 236 0.0321407500197871 313 25236134
SGTC_137 0438-0332 85.389 µM 1.84803105441469 0.0356204578018872 no 237 0.0322989252578936 430 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3150 9097574 49.47 µM 1.84607733708067 0.0357714502463644 no 238 0.0324404884792435 210 17217476
SGTC_740 k014-0057 261 µM 1.84289337579345 0.0360186452805371 no 239 0.032672289829215 303 4012779
SGTC_2120 5538279 151.968 µM 1.83960005391681 0.0362758010352073 no 240 0.032913488230773 272 2058197
SGTC_2639 lactacystin 53 µM 1.83932129185448 0.0362976367118616 no 241 0.0329339715792306 280 3870 A proteasome inhibitor.
SGTC_2932 9016711 44.54 µM 1.83655059634737 0.036515253161059 no 242 0.0331381331335548 315 7117328
SGTC_78 0336-0123 156.75 µM 1.8346276755539 0.0366669101796081 no 243 0.0332804375654764 235 6765896
SGTC_138 0850-0259 40.9225 µM 1.83124170813738 0.0369352069806185 no 244 0.0335322369661291 489 6813004
SGTC_340 k038-0059 454 µM 1.82559564082038 0.037386157201336 no 245 0.0339555964603055 293 23733424
SGTC_2047 4141938 200 µM 1.82490130061178 0.037441923233489 no 246 0.0340079624630523 220 3807862
SGTC_1375 2910-0797 186 µM 1.8237088436928 0.037537854091901 no 247 0.0340980505740108 281 742508
SGTC_145 3737-0113 38.366 µM 1.82368251615079 0.0375399743542321 no 248 0.0341000417872407 381 6849351
SGTC_56 0957-0365 83.25 µM 1.82350628230806 0.0375541696892875 no 249 0.0341133732247477 303 6752360
SGTC_2262 9014885 67.46 µM 1.81985480084993 0.0378492778054457 no 250 0.0343905598454389 171 6457424
SGTC_883 0850-0245 24.6 µM 1.81259246853085 0.0384418351431581 no 251 0.0349473501437913 308 6823229 YPR165W RHO1
SGTC_1397 3532-0190 20.1 µM 1.81229360458915 0.0384663815088645 no 252 0.0349704211115542 203 5322280
SGTC_3144 9087057 49.47 µM 1.79913358496869 0.0395599726792455 no 253 0.0359987760752925 275 17249618
SGTC_1602 st001878 87.6 µM 1.79771025970352 0.0396797507943245 no 254 0.0361114673614421 261 595405 YLR310C CDC25
SGTC_3321 9137793 26.8275 µM 1.79645141218364 0.0397859330855877 no 255 0.036211376760228 329 4904192
SGTC_656 4090-1979 187 µM 1.79599214048387 0.0398247295723705 no 256 0.0362478835083999 314 22330961
SGTC_2372 9071633 200 µM 1.79548652809554 0.0398674761982914 no 257 0.0362881086396949 271 21321366
SGTC_202 3594-0513 34.79 µM 1.79462668281324 0.0399402568196048 no 258 0.0363565994716081 230 708429
SGTC_2152 5568786 200 µM 1.79213229362264 0.0401520027230379 no 259 0.0365558885073347 274 5399883
SGTC_971 1315-0384 26.7 µM 1.7910409101974 0.0402449354033852 no 260 0.0366433651370164 304 6769120
SGTC_828 2074-0507 139 µM 1.78740312902163 0.0405559594562521 no 261 0.036936178134241 322 X828
SGTC_541 4513-1321 94 µM 1.78010887448474 0.0411854841077958 no 262 0.037529072254793 293 747515
SGTC_31 0508-1974 57.237 µM 1.77762380458385 0.0414017567788475 no 263 0.037732830733394 275 6810525
SGTC_846 0335-0850 148 µM 1.77541769868056 0.041594521911569 no 264 0.0379144718982334 254 6819598
SGTC_3209 9113616 49.47 µM 1.76953975444111 0.0421116762260904 no 265 0.0384019212993652 318 16649353
SGTC_1253 0550-0034 176 µM 1.76733908864964 0.0423066294388773 no 266 0.0385857286365075 291 5969915
SGTC_1930 st074634 34.3 µM 1.76708689074049 0.0423290177775491 no 267 0.0386068388026044 315 684253 YOR116C RPO31
SGTC_3259 9138485 49.47 µM 1.76389689040651 0.0426130315250326 no 268 0.0388746702505373 330 17646153
SGTC_612 0302-0167 22.4 µM 1.76312794560232 0.0426817225768414 no 269 0.0389394564549217 366 235821
SGTC_484 loperamide 105 µM 1.74911110521526 0.0439496302807344 no 270 0.0401359079927018 171 3955 An opioid-receptor agonist.
SGTC_3293 9120939 62.045 µM 1.7490220171887 0.0439577849272169 no 271 0.0401436068313536 283 934087
SGTC_1990 st072050 59.8 µM 1.74559048788661 0.0442728187888211 no 272 0.0404410681530719 279 17233948
SGTC_2069 5228469 200 µM 1.74134909221866 0.0446647148768537 no 273 0.0408112029303711 282 2835210
SGTC_3336 9143619 71.43 µM 1.73913891849515 0.0448700348725911 no 274 0.0410051652050839 328 45595730
SGTC_369 0957-0393 4.5 µM 1.73839894768758 0.0449389459875858 no 275 0.0410702709991505 297 6997992
SGTC_447 ml7 120 µM 1.73636851168611 0.0451284716781565 no 276 0.041249348115285 305 4216 Selective myosin light chain kinase inhibitor.
SGTC_213 1246-0773 967 nM 1.73479334887232 0.0452759436925337 no 277 0.0413887073486259 329 6251622
SGTC_2147 5545932 89.7195 µM 1.73112910027992 0.04562050299426 no 278 0.0417143705931721 282 797404
SGTC_2177 5811945 192 µM 1.73065273753194 0.0456654511194482 no 279 0.0417568597724662 304 5343475
SGTC_623 k072-0108 16.9 µM 1.7278627955247 0.0459294167586917 no 280 0.0420064129401509 316 5382803
SGTC_3043 9092303 49.47 µM 1.72764907192045 0.0459496883070546 no 281 0.0420255796478245 300 25236084
SGTC_52 0329-0193 875 nM 1.72734083992106 0.0459789365756854 no 282 0.042053234323268 321 3739292
SGTC_1738 st035555 74 µM 1.72539657564478 0.046163773555175 no 283 0.0422280140088881 343 5331140
SGTC_1048 3161-0300 24.5 µM 1.71701554829522 0.0469673805737542 no 284 0.0429881655716765 335 2165101
SGTC_1862 st057513 3.81 µM 1.71315723302484 0.0473410835417003 no 285 0.0433418085668616 294 5393163
SGTC_3124 9127567 49.47 µM 1.7091312400306 0.0477335637045272 no 286 0.0437133210018091 289 17592030
SGTC_1724 st037281 8.293 µM 1.70721934970521 0.0479208576049885 no 287 0.0438906449136712 356 574124 YDL195W SEC31
SGTC_309 k408-0051 1.48 µM 1.70510770263591 0.0481284034111924 no 288 0.0440871696594995 415 3640463
SGTC_2561 acetosyringone 100 µM 1.7012004030201 0.0485143334585515 no 289 0.0444526811041839 384 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2700 st077718 96.8 µM 1.70115822207467 0.0485185131974216 no 290 0.044456640235074 282 904970
SGTC_864 0469-0573 172 µM 1.70024505211376 0.0486090704489618 no 291 0.0445424206334422 309 689425
SGTC_1665 st014639 11.4 µM 1.69870033517568 0.0487625645372831 no 292 0.0446878301330468 366 981133 YIL048W NEO1
SGTC_2804 7954240 19.48 µM 1.6819185335504 0.0504552048189033 no 293 0.0462923191394284 366 828705
SGTC_1029 k015-0030 64.7 µM 1.68011767250889 0.0506395905357772 no 294 0.0464672115464908 339 2208316
SGTC_142 0335-0849 62.6745 µM 1.67972825993014 0.0506795320163273 no 295 0.0465050993891857 484 3889043 YPR107C YTH1
SGTC_2508 celastrol 40.54 µM 1.67618748119251 0.0510438568083052 no 296 0.0468507377649762 284 122724 Celastrol is a natural product and antioxidant.
SGTC_15 0266-0086 27.098 µM 1.67042792652077 0.0516409301300398 no 297 0.0474173640944389 432 1712902 YIL048W NEO1
SGTC_395 anisomycin 6.25 µM 1.66889676421459 0.051800591216596 no 298 0.0475689205001954 267 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1919 st067113 52.3 µM 1.66791600352523 0.0519030654521764 no 299 0.0476662011493852 366 1268243
SGTC_2302 7771753 200 µM 1.66246162206579 0.0524759057271387 no 300 0.0482101260981267 391 2203047
SGTC_1969 st069479 40.1 µM 1.66188349605993 0.0525369157856921 no 301 0.0482680682152396 303 3895485
SGTC_2199 6590217 200 µM 1.65999380794133 0.0527367287949638 no 302 0.0484578491066191 263 703109
SGTC_938 3126-1755 342 µM 1.65790466844013 0.0529583327991649 no 303 0.0486683548708444 333 1777771
SGTC_3335 9143315 29.6265 µM 1.65015186828214 0.0537871677845395 no 304 0.0494559391810026 324 4899691
SGTC_2846 9008642 19.48 µM 1.64963467632917 0.0538428231141556 no 305 0.0495088390926633 321 2992898
SGTC_1718 roemerine 11.9335 µM 1.64744450040171 0.0540790148281641 no 306 0.0497333574726653 410 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3064 1327-0027 10 µM 1.64613214141422 0.0542209339480018 no 307 0.0498682781800664 187 16000455 YPR107C YTH1
SGTC_622 1348-1566 26.3 µM 1.64169697350905 0.0547027370469392 no 308 0.0503264095968527 382 7340407
SGTC_3351 9150312 21.596 µM 1.6410707059329 0.0547710418997584 no 309 0.0503913694059812 369 4904905
SGTC_1055 3448-0672 86 µM 1.63775769914348 0.0551335025639442 no 310 0.0507361244772343 356 748378
SGTC_2333 9017922 200 µM 1.63389418782535 0.055558581844829 no 311 0.051140535185956 345 3163164
SGTC_3197 9113331 49.47 µM 1.63168283134389 0.0558030459697993 no 312 0.0513731593325734 386 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_351 caspofungin 25 nM 1.63138723159171 0.0558357885552311 no 313 0.0514043186882887 499 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_171 k064-0041 9.68 µM 1.62778912713897 0.0562355547025786 no 314 0.0517848033963977 285 53325
SGTC_3314 9135860 59.4275 µM 1.62729634851081 0.0562904799539532 no 315 0.0518370865309966 346 25252478
SGTC_234 nsc-17383 10.7 µM 1.62486412262586 0.0565621963183407 no 316 0.0520957571535833 408 408974
SGTC_66 0109-0187 42.4 µM 1.62465015894494 0.0565861486641038 no 317 0.0521185614708524 367 759417
SGTC_1361 1608-0041 5.61 µM 1.62305988172083 0.0567644241243817 no 318 0.0522883022951142 364 X1361
SGTC_2798 7813637 45.45 µM 1.61990703368267 0.0571191768197737 no 319 0.0526261243534466 389 956368
SGTC_1207 2099-0101 141 µM 1.61783155063677 0.0573536573381936 no 320 0.052849452469819 389 5837381
SGTC_3164 9100705 49.47 µM 1.61705476376513 0.0574416104189739 no 321 0.0529332301260895 277 17174235
SGTC_3207 9114163 49.47 µM 1.61566243310114 0.0575995250577298 no 322 0.0530836587025218 421 849233
SGTC_2930 9013230 14.89 µM 1.61493360957632 0.0576823224198188 no 323 0.0531625364597986 408 2995857
SGTC_1522 st012842 45.6 µM 1.60904030496747 0.0583552686839169 no 324 0.0538037643894943 352 3491067 YOR116C RPO31
SGTC_1777 st045864 34.765 µM 1.60758578997607 0.0585223023262923 no 325 0.0539629632255409 364 4691462
SGTC_3120 9124077 49.47 µM 1.60607482797798 0.05869621553359 no 326 0.054128734936744 340 18774327 YGL155W CDC43
SGTC_1772 st048439 82.2 µM 1.60538223385844 0.0587760692707168 no 327 0.0542048558912894 397 2927068 YDL195W SEC31
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.60470483424326 0.0588542535851669 no 328 0.0542793887806675 371 94937 An inhibitor of serotonin biosynthesis.
SGTC_3177 9107506 49.47 µM 1.60091446257614 0.0592932387699229 no 329 0.0546979329305845 287 8897194
SGTC_2431 5490079 200 µM 1.59644349131151 0.0598143438506071 no 330 0.0551949063169447 379 5722345
SGTC_64 000l-0018 272.079 µM 1.59402749530242 0.0600974248104894 no 331 0.0554649383546525 534 6811119
SGTC_720 r052-1644 49.9 µM 1.59089282033488 0.060466275163022 no 332 0.0558168493141394 331 1422863 YOR257W CDC31
SGTC_2738 aclarubicin 5.55 µM 1.58289999633314 0.0614147907370506 no 333 0.0567221297966405 266 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2340 7987427 183.45 µM 1.58207591680868 0.0615132422823803 no 334 0.0568161203685622 364 2239331
SGTC_2316 5844804 197.44 µM 1.58037408947335 0.0617169471178919 no 335 0.057010610854903 489 776813
SGTC_1122 capsaicin 818.572 nM 1.58003896594103 0.0617571226335692 no 336 0.0570489715878055 378 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_986 1493-0483 84 µM 1.5794548543091 0.0618271963178989 no 337 0.0571158819237191 349 40079
SGTC_2502 avocadyne acetate 18.59 µM 1.57502740479271 0.0623603606877202 no 338 0.057625059515407 456 3952079
SGTC_367 0335-0881 7.1 µM 1.57011715765975 0.0629558505970685 no 339 0.0581939288167205 428 23828853
SGTC_1341 1486-1360 280 µM 1.56583373460239 0.0634789318181793 no 340 0.0586937732070683 404 3976547
SGTC_2831 7999036 19.48 µM 1.56517980250244 0.063559085178193 no 341 0.0587703779731212 423 2988270
SGTC_913 3487-1245 167 µM 1.56443109437386 0.0636509520483374 no 342 0.0588581815888306 399 4016153
SGTC_2382 9035899 200 µM 1.5621167370742 0.0639355782004565 no 343 0.0591302453418342 395 6462679
SGTC_906 1165-0455 526 µM 1.55876644256744 0.0643493590529014 no 344 0.0595258346979496 355 3252859
SGTC_2215 7188065 200 µM 1.55318069158668 0.0650438550132289 no 345 0.0601899864129461 308 940217
SGTC_2433 5607874 27.82 µM 1.5385902326721 0.0668853844615555 no 346 0.0619521822726411 406 2252428
SGTC_1708 st033234 31.827 µM 1.5383590862766 0.0669148797510875 no 347 0.0619804200467058 420 674664
SGTC_2213 7173844 200 µM 1.53032856657216 0.0679458689767678 no 348 0.0629677103685983 399 892728
SGTC_2315 7733312 200 µM 1.52883114468759 0.0681394635187538 no 349 0.0631531546541149 365 726316
SGTC_2694 st077685 81.9 µM 1.52842519756858 0.0681920197798455 no 350 0.0632035013168459 407 2838096
SGTC_1006 4099-6547 255 µM 1.5246771459945 0.068678743294618 no 351 0.0636698223965698 405 3146833
SGTC_488 nitrendipine 139 µM 1.52316552426805 0.0688757995647794 no 352 0.0638586495037134 424 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_423 5-fluorouracil 457 µM 1.52153223881288 0.0690892056269815 no 353 0.0640631637089889 424 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_312 4092-0653 6.84 µM 1.51948855794868 0.0693569514636527 no 354 0.0643197829837839 516 1148278
SGTC_924 2046-0044 21.3 µM 1.5187603817467 0.0694525438514046 no 355 0.0644114108070348 410 3623589
SGTC_2823 7987624 58.44 µM 1.51739788476249 0.0696316801276089 no 356 0.064583128833992 451 2239440
SGTC_1311 1190-0148 100 µM 1.51479810998695 0.0699744759755522 no 357 0.0649117696333743 510 1961333
SGTC_3257 9139206 32.98 µM 1.50648297998222 0.0710795968119487 no 358 0.0659716165501827 315 4910041
SGTC_685 1278-0033 54.9 µM 1.49087964343314 0.0731894646560075 no 359 0.0679965483938876 459 3590572
SGTC_1879 gemcitabine 100 µM 1.4896499418025 0.0733577593538631 no 360 0.0681581515715895 416 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1550 gossypolone 36.6 µM 1.48629668649913 0.0738181837724306 no 361 0.0686003313903544 441 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1985 st071382 65.5 µM 1.48543031644204 0.0739375004683596 no 362 0.0687149349043568 417 6123237
SGTC_776 4476-4378 112 µM 1.48101512399724 0.0745478521438879 no 363 0.0693012716779734 396 2892008
SGTC_3131 9127911 49.47 µM 1.47981901608838 0.0747138611232975 no 364 0.0694607762110621 430 45595681
SGTC_2644 guaiazulene 100 µM 1.47859587141249 0.0748839141452949 no 365 0.0696241784091664 384 3515 A coloring agent.
SGTC_2955 9076254 12.21 µM 1.47649644864175 0.0751764836608694 no 366 0.06990533395819 396 16459619
SGTC_1179 1021-1431 9.29 µM 1.47637552443997 0.0751933618180613 no 367 0.0699215547485351 517 2840958
SGTC_3304 9125678 46.087 µM 1.47468069603446 0.0754302238807679 no 368 0.0701492041618487 468 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_250 brefeldin a 552.239 µM 1.47171436980492 0.0758461530967644 no 369 0.0705490127555139 360 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2016 5121758 140 µM 1.46940314871629 0.0761714343274795 no 370 0.070861736897671 492 2795203
SGTC_276 colchicine 750 µM 1.46924318378473 0.0761939870187196 no 371 0.0708834205970601 462 2833 A microtubule depolymerizer.
SGTC_125 0133-0007 11.75 µM 1.46922398269534 0.0761966944301485 no 372 0.0708860237016928 439 26541
SGTC_394 menadione 8.33 µM 1.46919736850887 0.0762004472316714 no 373 0.0708896319263316 452 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_216 k038-0035 28.382 µM 1.4687426049685 0.0762645940702399 no 374 0.0709513084062878 389 4444231 YPR107C YTH1
SGTC_299 1273-0059 1.44 µM 1.46671322638361 0.0765513497777249 no 375 0.0712270416684558 425 2848077
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.46423678337327 0.0769023868417371 no 376 0.0715646315547683 373 17037758
SGTC_3311 9131146 2.8755 µM 1.46297434524967 0.0770818083454266 no 377 0.071737199504025 485 4900406 YPR165W RHO1
SGTC_3180 9109287 49.47 µM 1.46193946768388 0.0772291253861279 no 378 0.0718788991744384 382 18891271
SGTC_2582 agaric acid 100 µM 1.46000001016562 0.0775057872656532 no 379 0.0721450355689695 793 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2650 prasterone 100 µM 1.45980596074163 0.0775335096080927 no 380 0.0721717049464019 336 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2467 5474540 200 µM 1.4586779689855 0.0776948061924474 no 381 0.0723268812781193 455 5413519
SGTC_1798 st045719 60.953 µM 1.45674112786885 0.0779723577848291 no 382 0.0725939261525753 383 3980186
SGTC_2437 5741531 144.16 µM 1.45653928838649 0.0780013248483505 no 383 0.0726217984664106 475 2262990
SGTC_958 1222-0007 33 µM 1.45433715753329 0.0783178951228053 no 384 0.0729264267291457 475 7312461
SGTC_710 3448-4187 58 µM 1.45176608805875 0.0786887343602896 no 385 0.0732833281076496 553 3946412
SGTC_2419 paclitaxel 166.5 µM 1.45154844703119 0.0787201868870576 no 386 0.0733136010433087 525 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3289 9119912 71.43 µM 1.4495684562836 0.0790067641723715 no 387 0.0735894488219902 447 17014829
SGTC_338 4055-0136 114 µM 1.44704742941017 0.079372791914362 no 388 0.0739418201031597 454 2900563
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.44602161202093 0.0795220971424444 no 389 0.0740855700746828 458 4213774
SGTC_1828 st055811 49 µM 1.44400760423251 0.0798158491756693 no 390 0.0743684181684096 385 5877589
SGTC_228 caffeine 993.056 µM 1.44395728354031 0.0798231991682978 no 391 0.0743754957706666 405 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1904 st060225 78 µM 1.43445470968572 0.0812203692463462 no 392 0.0757212723665909 435 66595
SGTC_463 ikarugamyin 104 µM 1.43079203603323 0.0817637937864866 no 393 0.07624491311611 346 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_448 monastrol 171 µM 1.42963242154377 0.0819364137367067 no 394 0.0764112725825948 443 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1441 4106-0040 13 µM 1.42687516538164 0.0823479608744152 no 395 0.0768079401891908 444 2904180
SGTC_2282 7944268 200 µM 1.42490681220517 0.0826427075031329 no 396 0.0770920701092973 504 2970414
SGTC_1604 st002052 72.4 µM 1.4247083004633 0.0826724772190038 no 397 0.077120769372027 466 6254834 YHR062C RPP1
SGTC_1846 st056244 14.8 µM 1.42322184800469 0.0828956488552124 no 398 0.0773359270090481 494 5393182
SGTC_1097 itavastatin 7.23 µM 1.42249784967843 0.0830045118475186 no 399 0.0774408876566358 472 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.41474785506544 0.0841765732888 no 400 0.0785712189280163 534 165506
SGTC_730 1436-0052 41.2 µM 1.41349226568381 0.0843676245431722 no 401 0.0787555169492588 412 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_108 0509-0257 621.132 µM 1.41306578276599 0.0844325924222763 no 402 0.0788181914694389 525 536624
SGTC_2205 7238770 200 µM 1.41096534025057 0.0847531091463712 no 403 0.0791274170360596 411 279867
SGTC_2827 7993847 71.43 µM 1.40900766126163 0.0850526615647031 no 404 0.0794164513804064 421 2985692
SGTC_1492 4158-0558 28.5 µM 1.40702847218931 0.0853563112570661 no 405 0.0797094730809043 448 3967268
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.40394683563267 0.0858307153204612 no 406 0.0801673407290522 512 1377
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.40360624853238 0.085883268042437 no 407 0.0802180667024608 592 6708739 YPR165W RHO1
SGTC_185 k048-0037 25.491 µM 1.40321074578504 0.0859443244847051 no 408 0.0802770020772992 489 6827589
SGTC_3125 9127534 49.47 µM 1.40071610329171 0.0863301881539597 no 409 0.080649492640552 361 1639235
SGTC_2545 solidagenone 89.61 µM 1.39826431997691 0.0867106834020779 no 410 0.0810168540766818 286 6708572 An anti ulcer agent
SGTC_419 nsc-638432 893 µM 1.39767889599389 0.0868017211411219 no 411 0.0811047572155931 479 368090
SGTC_3269 9137823 49.47 µM 1.3975408076482 0.0868232053016189 no 412 0.0811255020751775 434 17682936
SGTC_2824 7998404 51.95 µM 1.39665016725587 0.0869618690200014 no 413 0.081259398204312 447 837851
SGTC_1974 st069448 26.9 µM 1.39649678590919 0.0869857656359423 no 414 0.0812824739019243 451 6323587 YNR016C ACC1
SGTC_2435 5706476 10.6 µM 1.39234504215773 0.0876344666829105 no 415 0.0819089690365698 512 5725375
SGTC_1866 st057638 64 µM 1.38553030294758 0.088707069448007 no 416 0.0829451866081628 464 688802
SGTC_1642 st009582 77.7 µM 1.38441503313795 0.0888835338491416 no 417 0.0831157042061017 451 6739311
SGTC_1776 st049249 45.9 µM 1.37660126004769 0.0901272099657227 no 418 0.0843177805606865 517 1822314
SGTC_1339 1486-1321 22.7 µM 1.37489205540281 0.0904009698728879 no 419 0.0845824563296874 501 3469382
SGTC_3071 9117417 49.47 µM 1.36977873694664 0.0912236461952706 no 420 0.0853779907264748 394 45595590 YGL055W OLE1
SGTC_1047 2043-3044 82 µM 1.36946497288015 0.0912743075397857 no 421 0.0854269883001739 510 669592
SGTC_706 4262-0057 46.9 µM 1.36891976985986 0.0913623873642718 no 422 0.0855121776004484 503 883298
SGTC_1072 oxiconazole 14.9 nM 1.36766926825461 0.0915646490941173 no 423 0.085707811804996 537 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2061 5245884 80.95 µM 1.36527440484595 0.0919529309574425 no 424 0.0860834102135869 524 573863
SGTC_1189 1431-2119 7.28 µM 1.36130520801507 0.092599144240264 no 425 0.0867086289244089 523 3107275
SGTC_765 1319-0117 244 µM 1.35419206538727 0.0937656081882979 no 426 0.0878375548947769 469 3487746 YGL099W LSG1
SGTC_1250 0485-0349 40.2 µM 1.35321836252413 0.0939261232851593 no 427 0.0879929403417908 506 6842794 YDL195W SEC31
SGTC_3254 9136651 49.47 µM 1.35108987740421 0.0942777104523688 no 428 0.0883333218377267 531 16454030
SGTC_1328 1441-0025 69.2 µM 1.34585270801865 0.095146926718949 no 429 0.0891750115437732 462 4562601
SGTC_598 3937-0236 20.2 µM 1.34244604330545 0.0957154923911582 no 430 0.08972570707775 576 1379313
SGTC_2976 9009005 19.48 µM 1.34097789367458 0.0959612929684478 no 431 0.0899638150338377 513 2993148
SGTC_1597 7-benzyloxygramine 47.5 µM 1.33527111590574 0.0969211425927807 no 432 0.0908938142786345 673 260807
SGTC_2240 6690706 185.951 µM 1.32626625795746 0.0984500181188683 no 433 0.0923757595928601 439 805876
SGTC_2849 9019321 12.99 µM 1.32315572589047 0.0989822170649509 no 434 0.0928917980222244 484 16489627
SGTC_3038 9091290 49.47 µM 1.32271581572794 0.0990576533898465 no 435 0.092964950973779 540 25236843
SGTC_3019 9081971 49.47 µM 1.31486155508863 0.100411596624543 no 436 0.0942782176899172 568 16451803
SGTC_618 k072-0232 33.2 µM 1.31400332426718 0.100560355739179 no 437 0.0944225427700064 510 5872756 YGL099W LSG1
SGTC_2050 5263056 171 µM 1.31355232855116 0.10063859227198 no 438 0.0944984500977904 621 763468 YGL055W OLE1
SGTC_486 niguldipine 82 µM 1.30988744633401 0.101276004974363 no 439 0.0951169572868363 475 1236 A calcium channel blocker.
SGTC_893 0958-0369 48.9 µM 1.30412758824936 0.102283721353557 no 440 0.0960950419520445 573 6819948
SGTC_2705 st078069 42.8 µM 1.30401939007473 0.10230272070655 no 441 0.096113485638798 504 1530061
SGTC_1430 4049-0248 69.1 µM 1.30355958230956 0.102383490534243 no 442 0.0961918944619424 603 22774488
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.30320033393362 0.102446628362312 no 443 0.0962531880854961 539 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1944 st076371 56.9 µM 1.30297869723168 0.102485595085316 no 444 0.0962910172324543 533 24208455
SGTC_2133 5320837 200 µM 1.30193887432082 0.102668553862313 no 445 0.0964686410187539 497 2841355
SGTC_2754 granisetron 64.02 µM 1.30022837438667 0.102970035771497 no 446 0.09676135419778 568 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2449 5812982 45.77 µM 1.29985664771442 0.103035638947543 no 447 0.0968250529540574 502 776185
SGTC_1224 0823-0416 294 µM 1.29958698747998 0.103083248200816 no 448 0.096871280961814 547 3598164
SGTC_2855 9016525 58.44 µM 1.29931128304469 0.103131941091117 no 449 0.0969185618825342 540 43811474
SGTC_1452 4194-0072 190 µM 1.29861019359705 0.103255837595935 no 450 0.0970388689608331 610 1343545
SGTC_368 fentichlor 4.58 µM 1.2952393626101 0.103853039803052 no 451 0.0976188349290146 459 7329 A pesticide.
SGTC_429 1112-0049 25.5 µM 1.293314152507 0.104195246774577 no 452 0.0979512138989765 516 2836170
SGTC_916 4466-0038 42 nM 1.29171157306101 0.104480728803232 no 453 0.0982285240482184 694 5722064 YGL116W CDC20
SGTC_1281 0884-0031 11.8 µM 1.28768848989931 0.105199893210338 no 454 0.0989272109171634 583 1548255
SGTC_2766 oltipraz 83.91 µM 1.28049274920494 0.106495120633945 no 455 0.100185946596217 543 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3017 9080681 49.47 µM 1.27908463958239 0.106749920410734 no 456 0.100433626043534 535 16451914
SGTC_849 0386-0493 241 µM 1.27837321430261 0.106878821154031 no 457 0.100558931955091 529 726119
SGTC_2489 cantharidin 73.42 µM 1.27586658511248 0.107333883629829 no 458 0.101001342457834 574 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_639 0833-0042 114 µM 1.27342734618567 0.107778051175539 no 459 0.101433219331321 602 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2184 6075246 200 µM 1.27081567821981 0.108255082832593 no 460 0.101897114888773 565 2267320
SGTC_1022 4477-0945 21.3 µM 1.26957995581554 0.108481321348671 no 461 0.10211714651232 574 4648966
SGTC_281 1672-3440 14.9 µM 1.26845234626453 0.108688062988989 no 462 0.102318229105048 614 6833000
SGTC_2553 4-methylesculetin 85.09 µM 1.26466687416036 0.109384182605136 no 463 0.102995384710999 579 5319502
SGTC_1392 3455-1037 33.9 µM 1.2613847739697 0.109990323134565 no 464 0.103585125686741 579 981132
SGTC_184 1494-0393 24.714 µM 1.25987930773034 0.11026915849966 no 465 0.103856452181664 592 3090647
SGTC_767 0929-0023 86 µM 1.25900444824151 0.110431428565386 no 466 0.104014362592589 672 1204563
SGTC_1937 st074714 47.2 µM 1.2586596528926 0.110495428662407 no 467 0.104076645277313 560 17250970
SGTC_3268 9137683 49.47 µM 1.25811924204422 0.110595791935874 no 468 0.104174317690211 529 1953228
SGTC_433 pimozide 108 µM 1.25715921230963 0.110774246515996 no 469 0.104347994739102 455 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_100 0086-0128 49.5915 µM 1.25630548863026 0.11093311369386 no 470 0.104502616358155 640 93297
SGTC_2861 9024595 19.48 µM 1.25313115342557 0.111525248795399 no 471 0.105078990026666 460 16482810
SGTC_2676 harmalol 100 µM 1.2517379909339 0.11178583985386 no 472 0.105332675942412 610 5459187 A monoamine oxidase inhibitor
SGTC_1567 st069303 68.4 µM 1.25056794546513 0.112005033115177 no 473 0.10554607576625 607 5581319
SGTC_2506 ethyl hematommate 54.16 µM 1.24930716805381 0.112241567637151 no 474 0.105776373590412 498 3940691 An allergen.
SGTC_1431 4049-0260 9.09 µM 1.24572725807588 0.112915140101928 no 475 0.106432271465531 583 3854841
SGTC_2445 5742597 35.57 µM 1.24462968344221 0.113122229329885 no 476 0.106633951999079 564 1774255
SGTC_2995 9067767 71.4286 µM 1.24446586222315 0.113153162174508 no 477 0.106664077969169 520 11673567
SGTC_664 1222-0054 14.9 µM 1.24340189498649 0.11335420815082 no 478 0.106859886171826 610 6813991
SGTC_2125 5246583 200 µM 1.24308654828662 0.113413844604845 no 479 0.106917971089629 681 835267
SGTC_2575 plumbagin 510 nM 1.24178223607636 0.113660745884799 no 480 0.107158459292244 563 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1876 myriocin 605 nM 1.24158740364936 0.113697659781168 no 481 0.107194415822361 582 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_58 0957-0393 9 µM 1.24147813648158 0.113718365808527 no 482 0.10721458500084 838 6997992
SGTC_3271 9137798 49.47 µM 1.24070763272763 0.113864451864023 no 483 0.107356886812017 504 6498326
SGTC_2709 st078560 56 µM 1.2406248308391 0.113880158900045 no 484 0.107372187319354 587 17250903
SGTC_192 3455-0609 60.9 µM 1.24058886112084 0.113886982627132 no 485 0.10737883445624 572 3769639
SGTC_980 1473-0395 201 µM 1.23852728255827 0.114278566657868 no 486 0.107760306174859 533 768876
SGTC_479 n-linoleoylglycine 10 µM 1.23846008147433 0.114291347201798 no 487 0.107772757381587 547 6433346 An anti-infammatory.
SGTC_1839 st053978 48 µM 1.23482583557827 0.11498403764624 no 488 0.1084476649641 582 3788398
SGTC_1454 4239-0054 42.6 µM 1.23469931882287 0.115008205513786 no 489 0.108471214754241 640 1340767
SGTC_1200 1643-0193 18.4 µM 1.23337976309419 0.115260489038963 no 490 0.108717055782427 628 5403974
SGTC_1979 st071809 45.3 µM 1.23027536753551 0.1158555636933 no 491 0.10929700260119 604 4976333
SGTC_3255 9139072 49.47 µM 1.22728371109982 0.116431088739911 no 492 0.109857987834831 606 17646060
SGTC_460 trequinsin 123 µM 1.22688922418757 0.116507129918003 no 493 0.109932114612179 638 5537 A vasodilator.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.22654831134793 0.116572872541884 no 494 0.109996203362341 625 165521
SGTC_2470 5664817 21.68 µM 1.22224695610617 0.117404619127271 no 495 0.110807125866286 591 2859561
SGTC_3069 9117009 49.47 µM 1.22088110185366 0.117669609278068 no 496 0.111065520370845 477 41904981
SGTC_926 2268-1401 59.4 µM 1.21797205194396 0.118235405985581 no 497 0.111617296756436 608 2931578
SGTC_2163 5671233 125 µM 1.21729839189994 0.11836670359725 no 498 0.111745352966292 653 701023
SGTC_2450 5739737 12.93 µM 1.21659705736532 0.118503504492655 no 499 0.111878781444758 589 2262825
SGTC_2497 7-hydroxyflavone 100 µM 1.2159780336154 0.118624342819192 no 500 0.111996644973368 539 5281894
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.21469032501408 0.118875992587144 no 501 0.112242111982512 573 6708514
SGTC_1505 k297-0037 20.6 µM 1.21221264426892 0.119361252176863 no 502 0.112715496292391 626 4089396
SGTC_1924 st058459 75.1 µM 1.2109162133503 0.119615717522793 no 503 0.112963759036543 580 688683
SGTC_25 0118-0223 35.662 µM 1.21008749823666 0.119778579267097 no 504 0.11312265990741 591 5333628
SGTC_387 norethindrone acetate 66.7 µM 1.20989156520772 0.119817107495731 no 505 0.113160252124846 568 541197
SGTC_964 1287-0107 19.4 µM 1.20604481103443 0.120575302779573 no 506 0.113900106353124 666 51516812 YPR165W RHO1
SGTC_3063 1327-0034 4 µM 1.20394885935122 0.12098983375853 no 507 0.11430467274507 584 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2885 9057732 51.95 µM 1.20357578432114 0.121063724408661 no 508 0.114376791862311 613 6471414
SGTC_1143 3454-2408 5.08 µM 1.19682117268264 0.122407025335511 no 509 0.11568813195724 579 X1143
SGTC_1149 3909-7961 23.3 µM 1.19668050363193 0.122435111176684 no 510 0.115715554493215 612 735261
SGTC_455 paf C-16 10 µM 1.19343875556945 0.123083608606571 no 511 0.116348792205116 593 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2462 5162487 171.77 µM 1.19123105473213 0.12352662528827 no 512 0.116781445714022 637 2259986
SGTC_2241 6772625 37.8075 µM 1.18767703117624 0.124242150783148 no 513 0.117480338159762 600 2285411
SGTC_160 3453-0671 289.699 µM 1.18751087458648 0.124275673597671 no 514 0.117513084867315 638 5322268
SGTC_2737 bleomycin 30.5 nM 1.18526121787924 0.124730174390143 no 515 0.117957091071791 685 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_552 k242-0005 476 µM 1.18290360966302 0.125207730000354 no 516 0.118423675457483 622 4088318
SGTC_3010 9080089 71.4286 µM 1.18217732408897 0.125355102839729 no 517 0.118567674087798 645 17027233
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.1818822537383 0.125415011049409 no 518 0.118626212201715 703 66535 A nucleotide analog.
SGTC_179 1273-0063 6.77 µM 1.17939689030255 0.125920408135778 no 519 0.11912008641131 582 3108139
SGTC_2968 9090663 33.37 µM 1.17547013702542 0.126721802446883 no 520 0.11990333889494 643 25236811
SGTC_1456 k015-0012 13 µM 1.17453036193115 0.126914122686065 no 521 0.120091328989489 724 2989616
SGTC_674 0498-0004 451 µM 1.17124367486428 0.127588324051124 no 522 0.120750422236864 619 4231473
SGTC_1524 corynanthine 62.1 µM 1.17017150399508 0.127808797191182 no 523 0.120965978956788 621 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1739 st037196 92.5 µM 1.1691392781315 0.12802130636468 no 524 0.121173760529839 700 612214
SGTC_1561 5-methoxyflavone 52.9 µM 1.16837374830922 0.128179068019033 no 525 0.121328019644988 586 94525
SGTC_522 1273-0010 11.6 µM 1.16614313774969 0.12863952562809 no 526 0.121778289025052 621 5705015
SGTC_55 0767-0285 6.563 µM 1.16336275159158 0.129215076940479 no 527 0.122341177756456 691 3116166
SGTC_1987 st072290 61.9 µM 1.16166454025855 0.129567490447899 no 528 0.122685877365609 671 54697379
SGTC_1949 st076024 69.1 µM 1.16078035851541 0.129751239547402 no 529 0.122865616280111 626 2921930
SGTC_2028 5153890 36.43 µM 1.16072786224958 0.129762154901751 no 530 0.122876293670463 641 2830968 YPR165W RHO1
SGTC_949 1165-0505 146 µM 1.15984235501738 0.129946370976485 no 531 0.123056497993662 702 6244267
SGTC_2598 perillyl alcohol 100 µM 1.15912750860673 0.130095215715975 no 532 0.123202107224144 674 10819 An apoptosis inducer.
SGTC_1603 st002045 67.8 µM 1.15883755609426 0.130155623016068 no 533 0.12326120293647 664 5887985
SGTC_1347 1493-0251 600 nM 1.15461720260087 0.131037068672181 no 534 0.124123609466724 692 3986378
SGTC_1300 1094-0077 113 µM 1.15344920808325 0.131281738131974 no 535 0.124363026905873 616 5532636
SGTC_1027 k015-0025 8.67 µM 1.15301188194141 0.131373429576784 no 536 0.124452753783311 658 3598955
SGTC_2063 5246145 200 µM 1.15243117265359 0.131495251596982 no 537 0.124571968746648 681 711240
SGTC_2471 5466956 24.79 µM 1.15160659400926 0.131668366819684 no 538 0.124741385257479 646 724419
SGTC_2044 5102272 200 µM 1.14676819311192 0.132687327960118 no 539 0.125738719037984 608 592666
SGTC_2189 6047310 154.431 µM 1.14598402010974 0.132852983922227 no 540 0.125900882045409 641 711535
SGTC_259 usnic acid 108.925 µM 1.13855399088126 0.134429639703275 no 541 0.127444613827049 697 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_874 0599-0792 117 µM 1.13613865045307 0.134944931875793 no 542 0.127949270696446 748 765305
SGTC_1982 st072467 71.9 µM 1.13601335661437 0.134971699156151 no 543 0.127975487191959 729 3163533
SGTC_2784 7567673 72.73 µM 1.13434411833463 0.135328656085485 no 544 0.128325114865627 710 3471247
SGTC_2662 daunorubicin 22.37 µM 1.13425599825261 0.13534751801913 no 545 0.128343590330125 635 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2811 7967822 32.47 µM 1.1328207160457 0.135654991114051 no 546 0.128644775017653 673 2232244
SGTC_2591 skatole 100 µM 1.12822140590012 0.136643499277119 no 547 0.12961321293615 662 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_600 1495-0418 41.6 µM 1.12253165395328 0.137873171202828 no 548 0.130818228293786 649 5377768
SGTC_1768 st044301 37.178 µM 1.12232463124475 0.137918054941102 no 549 0.130862218520537 711 3931349
SGTC_991 3996-0057 64.7 µM 1.1212958310952 0.138141252688248 no 550 0.131080979754604 689 715343
SGTC_594 1487-1584 10.8 µM 1.12048125644504 0.138318148923934 no 551 0.131254367776741 684 5013332
SGTC_2145 5634607 200 µM 1.1201460482577 0.138390988878385 no 552 0.131325765210126 613 308662
SGTC_2781 5567276 71.43 µM 1.11960145836469 0.138509382717506 no 553 0.131441816921533 657 2853274
SGTC_1736 st036774 51 µM 1.11941779787388 0.138549326065193 no 554 0.131480970798968 723 1272247
SGTC_462 ag-879 158 µM 1.1177787515223 0.138906141135589 no 555 0.131830749371227 724 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_704 1310-0270 142 µM 1.11710134003673 0.13905379399784 no 556 0.131975498809997 710 5718033
SGTC_1030 k029-0042 36.7 µM 1.11245447558505 0.140069533539217 no 557 0.132971396720641 738 6080581
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.11139979931911 0.140300771166013 no 558 0.133198149339877 640 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_518 1021-0119 62.6 µM 1.11055971037686 0.140485145950426 no 559 0.133378956533645 667 1097762
SGTC_1891 st059073 26.2 µM 1.10937380335492 0.140745697506552 no 560 0.133634479312542 753 688754
SGTC_1491 4138-0063 26.5 µM 1.10909524880069 0.140806945296246 no 561 0.133694547163748 662 23883227
SGTC_2830 7992007 71.43 µM 1.108541987865 0.140928648372117 no 562 0.133813908084506 665 1952075
SGTC_1313 1220-0047 237 µM 1.09959221102227 0.142907281710093 no 563 0.135754918588341 743 3528706
SGTC_1214 0358-0031 63.7 µM 1.0989761756363 0.143044163206882 no 564 0.135889228916992 693 4301366
SGTC_808 0711-0032 135 µM 1.09415618354917 0.144118210810741 no 565 0.136943242414528 722 4252555
SGTC_1209 2323-2347 50.3 µM 1.09404809164038 0.144142359303685 no 566 0.136966943328124 711 5412760
SGTC_379 3970-0972 5.9 µM 1.09037379504875 0.144964845728065 no 567 0.137774260157456 706 2898042 YBL034C STU1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.08979835823444 0.14509394208026 no 568 0.137900988666172 808 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3119 9125183 49.47 µM 1.08628738913513 0.145883286295514 no 569 0.138675932294256 568 22695334
SGTC_1420 4'-methoxyflavone 42 µM 1.08522470009703 0.146122770379004 no 570 0.138911073494118 734 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1814 st052110 31.539 µM 1.08356734697413 0.146496792812884 no 571 0.139278337599889 688 674163
SGTC_269 exalamide 29 µM 1.08152569284676 0.146958424897181 no 572 0.139731669087133 701 3316 A derivative of salicylamide.
SGTC_1139 k015-0024 46.9 µM 1.07908287836074 0.147512042751653 no 573 0.14027539156462 735 2766652
SGTC_1983 st071813 46.9 µM 1.07898764013346 0.147533654962474 no 574 0.14029661878482 728 11838595
SGTC_90 0870-0863 4.608 µM 1.07833489653632 0.14768183778628 no 575 0.140442164583155 763 1738164
SGTC_1713 st033146 12.748 µM 1.07602782887522 0.148206376123854 no 576 0.140957405321541 740 674619
SGTC_1458 k015-0034 6.33 µM 1.07532602973337 0.148366185185174 no 577 0.141114393150889 686 3598957
SGTC_2257 7960413 200 µM 1.07284663175516 0.148931699919323 no 578 0.141669967166806 778 2974689 YIL048W NEO1
SGTC_917 harmaline 728.087 nM 1.06688107430572 0.150298251460313 no 579 0.143012771017502 732 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2478 5763493 32.33 µM 1.06536672308442 0.150646474919722 no 580 0.143355004699908 764 1365576 YLR208W SEC13
SGTC_599 1935-0052 86.5 µM 1.06489812249244 0.150754337894852 no 581 0.143461017380836 759 9557311
SGTC_3052 9092717 49.47 µM 1.05720782397948 0.152531844623908 no 582 0.145208374924907 709 25237534
SGTC_3214 9129694 49.47 µM 1.05643563132984 0.15271109150703 no 583 0.145384617172023 709 17158655
SGTC_1396 3511-0007 98.6 µM 1.05614403477918 0.152778815312737 no 584 0.145451207446137 667 X1396
SGTC_1371 2421-0008 32.7 µM 1.05467717816627 0.153119797401934 no 585 0.145786496408598 717 2827552
SGTC_1981 st071826 47 µM 1.0495262910524 0.154321153285864 no 586 0.146967980685684 706 11838600
SGTC_1064 honokiol 6.76 µM 1.04920353744571 0.154396636960728 no 587 0.147042225453653 756 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_754 3474-0146 171 µM 1.04746314390564 0.154804090397771 no 588 0.147443011053979 694 24762078
SGTC_1710 st031758 61.5 µM 1.04702611442531 0.15490651733971 no 589 0.147543767024963 744 5394341
SGTC_825 1988-2224 89.6 µM 1.0454516595901 0.155275894592054 no 590 0.14790713569078 769 1180859
SGTC_2366 9070441 60.58 µM 1.04463076256124 0.155468712704366 no 591 0.148096828047161 766 6837235
SGTC_987 1497-1013 404 µM 1.04011886375072 0.156531318658134 no 592 0.149142340344367 739 1676435
SGTC_644 1498-1197 63.3 µM 1.03236989346286 0.158367426444364 no 593 0.150949435037602 802 6741615
SGTC_1958 st076513 41.9 µM 1.03068999331071 0.158767332594286 no 594 0.15134310940924 755 732122 YGL099W LSG1
SGTC_1381 2324-0066 62.1 µM 1.03008636532113 0.158911189891965 no 595 0.151484732560372 723 10885928
SGTC_2386 9075165 157.42 µM 1.02971158704752 0.159000550439358 no 596 0.151572707332878 762 16452277
SGTC_932 2857-0803 154 µM 1.02614833882647 0.159851800632455 no 597 0.152410834066002 821 674898
SGTC_504 lovastatin 124 µM 1.02586818198903 0.159918855507632 no 598 0.152476861120312 702 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1233 0325-0408 14.2 µM 1.0242945175923 0.160295850204186 no 599 0.152848093332109 774 12874
SGTC_2742 clothiapine 36.27 µM 1.02181573127972 0.160890857392164 no 600 0.153434061176019 729 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_810 3825-7150 143 µM 1.02078772126506 0.161138043056951 no 601 0.153677511532888 842 22330411 YGL099W LSG1
SGTC_2434 5670830 169.91 µM 1.02013401167261 0.161295356761053 no 602 0.153832454095141 768 1549830
SGTC_316 k060-0003 58.6 µM 1.01480568238287 0.162581341509067 no 603 0.155099232259444 770 6152314
SGTC_1170 0310-0127 64.8 µM 1.01192032415841 0.163280495199539 no 604 0.155788075361746 808 774975
SGTC_2268 7933382 153.85 µM 1.01156129480967 0.163367628372603 no 605 0.155873930022093 870 935025 YOR257W CDC31
SGTC_1342 1486-1464 234 µM 1.00989080025177 0.163773439418735 no 606 0.156273805383373 814 3253938
SGTC_1802 st050112 57.9 µM 1.00944255345959 0.163882442668109 no 607 0.156381219544121 790 4662563
SGTC_3159 9100096 49.47 µM 1.00822283200888 0.164179289001459 no 608 0.15667374964182 765 25236875
SGTC_22 0964-0034 14.468 µM 1.0068727044329 0.164508278943209 no 609 0.156997975246109 821 138402
SGTC_2505 galangin 7.89 µM 1.00600881319316 0.164719010117517 no 610 0.157205665300999 719 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_584 0986-0246 15.4 µM 1.00460301923896 0.165062302660208 no 611 0.157544021434166 871 53315 YDR232W HEM1
SGTC_2928 9011484 9.79 µM 1.00339050464601 0.165358768481337 no 612 0.157836241852977 743 2994751
SGTC_36 0335-0881 14.2 µM 1.00269977008683 0.16552781044238 no 613 0.158002870439531 842 23828853
SGTC_2099 5377090 177.372 µM 1.00134997249369 0.165858465965095 no 614 0.158328820595849 782 2243829
SGTC_1658 st012944 20 µM 0.999579845342148 0.166292734857229 no 615 0.158756940415965 781 24207260
SGTC_1372 2752-0194 270 µM 0.998937593964288 0.166450481081311 no 616 0.158912461646601 751 823334
SGTC_1439 4092-1168 46 µM 0.998070721014752 0.166663550758201 no 617 0.15912253328676 812 2886240
SGTC_1992 st073643 23.3 µM 0.996986733739188 0.166930232754728 no 618 0.159385474669785 787 3161292
SGTC_2621 lithochol-11-enic acid 100 µM 0.99554550367659 0.1672852294338 no 619 0.159735512282841 838 6708711
SGTC_2567 aureobasidin a 60 nM 0.995488828302424 0.167299199368678 no 620 0.159749287540384 779 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3045 9092950 49.47 µM 0.994360468610394 0.1675774856794 no 621 0.160023703263815 847 44120432
SGTC_2084 5306078 60.6385 µM 0.987976987521124 0.169157448754424 no 622 0.161581959325915 785 679340
SGTC_1637 st007924 17.4 µM 0.987237143969908 0.169341182549765 no 623 0.161763198281042 791 683336
SGTC_1841 st054148 70 µM 0.987115734454759 0.169371345791086 no 624 0.161792952533447 755 675442
SGTC_3004 9076122 71.4286 µM 0.98676345142911 0.169458887262127 no 625 0.161879307946438 817 44782551
SGTC_819 1013-0258 27.7 µM 0.98419024407112 0.17009920339328 no 626 0.16251099085995 805 5753198
SGTC_3029 9088683 49.47 µM 0.982697239000331 0.170471432214354 no 627 0.16287823500097 797 25236615
SGTC_60 0986-0278 202 µM 0.982450518032899 0.170532993680412 no 628 0.162938974472854 674 3110598
SGTC_843 0310-0051 143 µM 0.981861603277911 0.170679996388964 no 629 0.163084017095332 817 2065037
SGTC_858 0438-0351 2.77 µM 0.981337116333517 0.170810985135782 no 630 0.163213262550646 864 2799119
SGTC_3054 9094397 49.47 µM 0.978479903366586 0.171525693316872 no 631 0.163918513045132 832 2598354
SGTC_894 0960-0238 55.9 µM 0.978184277452724 0.171599750627762 no 632 0.163991595584421 855 6741907 YDL195W SEC31
SGTC_2003 4023581 200 µM 0.97461073921034 0.172496574061322 no 633 0.164876692265412 803 16641307
SGTC_1242 0402-0103 60.1 µM 0.973447559391729 0.172789132033621 no 634 0.165165455711937 768 432868
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.970892641945908 0.173432843327612 no 635 0.16580087132327 865 688664
SGTC_544 k015-0020 52.4 µM 0.970713013007077 0.17347815818856 no 636 0.165845604958025 813 3008304
SGTC_2647 atorvastatin 60.16 µM 0.969386466723972 0.173813038330555 no 637 0.166176201021359 822 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2989 9073649 71.4286 µM 0.968683531843787 0.17399065736391 no 638 0.166351555813782 911 21367202
SGTC_1465 k213-0056 144 µM 0.968018397303805 0.174158831151157 no 639 0.166517590879665 806 24048857 YMR208W ERG12
SGTC_2089 5281248 129.67 µM 0.967521826131198 0.174284452414817 no 640 0.166641617818843 829 2737878
SGTC_3292 9120825 59.784 µM 0.96713825980172 0.174381525414297 no 641 0.166737460712305 863 24824900
SGTC_785 1270-0111 65.3 µM 0.966550323528862 0.174530387038858 no 642 0.166884439178301 830 6741994
SGTC_2295 7971645 200 µM 0.966338852122773 0.17458394994675 no 643 0.166937325444636 811 2978226 YKL099C UTP11
SGTC_835 0312-0010 67.2 µM 0.964499855219058 0.175050183535474 no 644 0.16739769048184 798 1626196
SGTC_2313 7726885 200 µM 0.961436544385855 0.175828564550357 no 645 0.168166358479046 806 726423
SGTC_2280 7785178 200 µM 0.958645267840006 0.176539728029897 no 646 0.168868739824837 824 2954328
SGTC_601 0986-0029 62.9 µM 0.958637634728794 0.176541675290437 no 647 0.168870663159096 871 24747981
SGTC_1063 disulfiram 1.84 µM 0.958338838631818 0.176617910956883 no 648 0.168945962622405 824 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_500 h-89 112 µM 0.958082150001131 0.176683419828671 no 649 0.169010667823587 901 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2775 cyproheptadine 69.59 µM 0.95713339095733 0.176925683590831 no 650 0.169249965911283 854 2913 A selective serotonin reuptake inhibitor.
SGTC_557 1315-0110 16.2 µM 0.954570948688334 0.177581046735419 no 651 0.169897357178189 858 6833801
SGTC_1270 0831-1170 17.3 µM 0.953586314494186 0.177833280982152 no 652 0.170146542937893 912 6764716
SGTC_892 0929-0076 29 µM 0.949481016083139 0.178887371029328 no 653 0.17118801137609 869 5751038
SGTC_2933 9026794 32.47 µM 0.947754936522901 0.17933173680136 no 654 0.171627113224727 860 17586027
SGTC_2412 st077135 33.4 µM 0.939340059385908 0.181508008572202 no 655 0.173778088659163 840 13258915
SGTC_1 0258-0098 57.368 µM 0.938985791253111 0.18159999125184 no 656 0.173869019754876 760 6790032 YDR047W HEM12
SGTC_878 0828-0289 13.7 µM 0.936400085301554 0.182272230775669 no 657 0.174533617029378 871 745350 YLR208W SEC13
SGTC_98 0074-0023 107.663 µM 0.933093675945276 0.18313410334715 no 658 0.175385802027164 900 3563821
SGTC_2218 6965428 192.983 µM 0.930820173917077 0.183728203268041 no 659 0.175973296153881 882 675684
SGTC_1500 4488-1866 171 µM 0.928856707688622 0.184242251323157 no 660 0.176481675725221 941 2900003
SGTC_1080 nisoldipine 24.4 µM 0.927870254772365 0.18450084848775 no 661 0.176737437816338 887 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_262 fenpropimorph 62.5 µM 0.92672880466158 0.184800359530454 no 662 0.177033679023141 823 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_738 1315-0003 72.4 µM 0.926449802900017 0.184873614194796 no 663 0.177106136197805 899 6251474
SGTC_2312 7706453 155.7 µM 0.925766301422848 0.185053150495177 no 664 0.177283721704225 844 976098
SGTC_402 epigallocatechin gallate 10 µM 0.922583440031183 0.18589062302575 no 665 0.178112164417411 892 65064 An antioxidant.
SGTC_1314 1222-0010 41.1 µM 0.921903482823834 0.186069837167203 no 666 0.178289461157884 892 3526027
SGTC_3112 9123419 49.47 µM 0.920325267320311 0.18648621498723 no 667 0.178701404435701 940 17015854
SGTC_555 4296-0685 37 µM 0.919079165649583 0.186815379158401 no 668 0.179027082925474 921 2908540 YHR072W ERG7
SGTC_976 1348-1067 47.6 µM 0.918573814102462 0.186948972792973 no 669 0.179159266903603 963 5310671 YGL099W LSG1
SGTC_871 0574-0004 149 µM 0.917221211100623 0.187306834715428 no 670 0.179513367023396 891 9551173
SGTC_2620 irigenin 100 µM 0.916193093842428 0.187579129652708 no 671 0.179782813552252 909 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2866 9034245 58.44 µM 0.916044813754945 0.187618421529222 no 672 0.179821695398574 893 6462273
SGTC_1340 1486-1359 257 µM 0.915614906659067 0.187732368846904 no 673 0.179934455033473 901 4309068
SGTC_2031 5180455 200 µM 0.915605420931861 0.187734883530555 no 674 0.179936943530066 861 29949
SGTC_297 0986-0032 24 µM 0.91534659096002 0.187803507859276 no 675 0.180004853623458 866 2847425
SGTC_1847 st056231 15 µM 0.915193273711246 0.187844164604142 no 676 0.180045087576337 942 5393180
SGTC_187 1488-2104 32.728 µM 0.913730564052222 0.188232319922434 no 677 0.180429219896535 936 2852859
SGTC_509 pifithrin 175 µM 0.913313882154181 0.188342984181842 no 678 0.180538741643922 955 4817 A p53 inhibitor.
SGTC_1783 st039459 87.517 µM 0.912611600275937 0.188529590176206 no 679 0.180723425566881 951 729761
SGTC_3091 9116372 49.47 µM 0.912220140409225 0.18863365593696 no 680 0.180826421870881 849 17169793
SGTC_2159 5658611 73.75 µM 0.910900865119917 0.188984633021501 no 681 0.181173804906776 936 793844
SGTC_2426 5582046 32.21 µM 0.910672896492997 0.189045322029419 no 682 0.181233874460139 902 2251934
SGTC_2745 rifampicin 24.3 µM 0.906482923243193 0.190162898921485 no 683 0.182340149751834 775 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3258 9138477 49.47 µM 0.904679327617392 0.190645212911162 no 684 0.182817647945171 904 4970355
SGTC_43 0570-0105 72.5 µM 0.904244502980254 0.190761605097743 no 685 0.182932883530851 959 1114046 YDL195W SEC31
SGTC_1955 wogonin 32.4 µM 0.901292728217424 0.191552877034262 no 686 0.183716349554432 902 5281703 A flavanone.
SGTC_1167 k781-0610 148 µM 0.899131871088095 0.192133403199915 no 687 0.184291211880257 939 4525169
SGTC_1442 4112-3290 3 µM 0.897776524064446 0.192498073351666 no 688 0.18465235137149 944 704353
SGTC_81 0411-0046 9.971 µM 0.895670934621126 0.193065442608524 no 689 0.185214269092188 846 12925265
SGTC_1426 4048-4480 71.7 µM 0.894930307545642 0.193265253457921 no 690 0.185412172107269 931 14224343
SGTC_1156 4092-0367 4.88 µM 0.894364041490535 0.193418109240287 no 691 0.185563572617408 914 1357585
SGTC_3245 9134821 49.47 µM 0.894119341362826 0.193484185512364 no 692 0.185629020939615 948 17014901
SGTC_1227 3909-8010 46.6 µM 0.891177754521007 0.194279578250163 no 693 0.186416908299482 883 15982272
SGTC_1612 st002233 45.4 µM 0.88870842199624 0.194948810291686 no 694 0.187079901824529 906 1035021
SGTC_3233 9132340 49.47 µM 0.888505413269724 0.195003891472224 no 695 0.187134472644399 890 17682950
SGTC_1159 4092-0538 61.2 µM 0.88832925606233 0.19505169485224 no 696 0.187181833478694 970 717301
SGTC_1469 k284-2957 126 µM 0.887749612411041 0.195209041708822 no 697 0.187337726181152 934 23884841
SGTC_197 4544-0043 41.561 µM 0.886523975739747 0.195542000143006 no 698 0.187667620160256 953 896523
SGTC_345 1362-0200 395 µM 0.886315711992389 0.195598611667944 no 699 0.18772371235598 895 1419823
SGTC_3194 9111903 49.47 µM 0.885767729902664 0.195747615042001 no 700 0.187871351207898 897 17087251
SGTC_115 0527-0192 112.043 µM 0.885108562772139 0.195926942312712 no 701 0.188049040810426 987 4233931
SGTC_1562 morin hydrate 59.1 µM 0.88443214154862 0.196111067168912 no 702 0.188231489351825 901 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2248 tofa 1.1 µM 0.883572532089356 0.196345208038015 no 703 0.188463506100886 901 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1127 asiatic acid 681.4 nM 0.882398953636674 0.196665141399394 no 704 0.18878055068559 869 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1620 st003704 16.5 µM 0.879144567080181 0.197553981755213 no 705 0.189661447940512 951 2834414
SGTC_815 1582-0027 36.9 µM 0.878192175516336 0.197814558256456 no 706 0.18991971874432 945 3128206
SGTC_2763 lisinopril 49.32 µM 0.876191989729894 0.19836248925096 no 707 0.190462835220521 907 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1864 st057645 30.4 µM 0.873870049589908 0.198999709069289 no 708 0.191094513462613 954 688666
SGTC_965 1291-5240 308 µM 0.870659132496635 0.199882924093455 no 709 0.191970149462925 940 2834598
SGTC_944 3370-0224 231 µM 0.870138320713124 0.200026403730065 no 710 0.192112409013319 941 4580514
SGTC_61 0978-8327 98.565 µM 0.868578566251843 0.200456474327347 no 711 0.192538841083557 1002 6150059 YHR072W ERG7
SGTC_735 3076-0345 636 µM 0.868464976304075 0.200487816128029 no 712 0.192569918812376 979 2888990
SGTC_2146 5545642 200 µM 0.86815601743842 0.200573079115432 no 713 0.192654464160407 983 825326
SGTC_3024 9090631 49.47 µM 0.867976131892731 0.20062273192937 no 714 0.192703699561681 924 25236383
SGTC_2975 9084847 53.72 µM 0.867373901213567 0.200789016041823 no 715 0.192868588485095 942 27211724
SGTC_2825 7998094 58.44 µM 0.866665489816529 0.200984723942955 no 716 0.193062659641926 909 2987815
SGTC_2119 5528445 120.635 µM 0.866214704580818 0.201109318808701 no 717 0.193186215491114 950 791935
SGTC_2094 5332512 191.667 µM 0.862330994177463 0.202184675122615 no 718 0.194252700833198 997 755774
SGTC_2093 5331342 194.4 µM 0.861328461063066 0.202462823046185 no 719 0.194528582327977 975 33839
SGTC_2168 5727979 200 µM 0.859812590914305 0.202883828062477 no 720 0.194946178777963 904 695210
SGTC_2520 obtusaquinone 4.71 µM 0.859091525420922 0.203084274122171 no 721 0.19514501122811 970 5967872
SGTC_483 fpl-64176 144 µM 0.858113909902063 0.203356226224424 no 722 0.195414783618705 926 3423
SGTC_3090 9117696 49.47 µM 0.857409305049889 0.20355236717225 no 723 0.195609359286713 934 7923821
SGTC_1770 st043884 66.3 µM 0.856731060229266 0.20374127681247 no 724 0.195796766737519 996 670149
SGTC_630 4356-0227 183 µM 0.856136436550003 0.203906981642366 no 725 0.195961158243385 932 779312
SGTC_2322 7413319 38.22 µM 0.853409508106792 0.204667927700246 no 726 0.196716125295423 994 1840400
SGTC_2536 dehydroabietamide 32.04 µM 0.852482713474564 0.204926932767226 no 727 0.196973114717265 992 3983547
SGTC_1596 piperlongumine 63 µM 0.851860790683269 0.205100846559217 no 728 0.197145680596151 1017 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1678 st019265 80.2 µM 0.850615740769811 0.205449274384598 no 729 0.197491421290474 999 5367020
SGTC_3076 9116187 49.47 µM 0.850515472950907 0.205477349667861 no 730 0.197519280827099 942 27241210
SGTC_2717 st081029 62.2815 µM 0.850213905749326 0.205561803097038 no 731 0.197603085963187 957 5292846
SGTC_3198 9112019 49.47 µM 0.849302201431654 0.205817249778002 no 732 0.197856578100689 972 45595555
SGTC_1588 farnesol 29.9 µM 0.848685880113055 0.205990040960455 no 733 0.198028052584035 954 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_117 lucigenin 22.078 µM 0.847792105259639 0.206240771513807 no 734 0.19827688027798 1013 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2963 9082507 9 µM 0.846868167787345 0.206500153650869 no 735 0.198534303542881 909 16459611
SGTC_3021 9087658 49.47 µM 0.846776642390459 0.206525858603404 no 736 0.198559814903545 984 25237042
SGTC_826 1683-5028 118 µM 0.845152139534606 0.206982416326628 no 737 0.199012950165868 949 722377
SGTC_2238 6671620 73.2395 µM 0.843935289505781 0.207324796338433 no 738 0.19935278348563 1013 729941
SGTC_2743 auranofin 4.32 µM 0.843738039076206 0.207380327391536 no 739 0.199407903089824 956 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3213 9129884 49.47 µM 0.842081350224312 0.207847074747082 no 740 0.199871209801429 930 17190742
SGTC_3352 9151559 45.5865 µM 0.842054880958978 0.207854537099148 no 741 0.199878617400482 944 17159339
SGTC_426 0988-0037 14.6 µM 0.841454234969798 0.208023916848314 no 742 0.200046756535145 1014 5383008
SGTC_2767 sibutramine 71.45 µM 0.84052233786206 0.20828686929034 no 743 0.200307791200623 985 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_257 daunorubicin 18.5 µM 0.836802117110518 0.209338552318032 no 744 0.201351903591914 999 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_287 k060-0039 29.6 µM 0.836407175335815 0.209450383072966 no 745 0.201462938667318 1012 5861974
SGTC_860 0443-0016 25.1 µM 0.83235029836119 0.210601151945566 no 746 0.202605623694128 1058 5337942
SGTC_2465 5809242 33.21 µM 0.831256668229009 0.210912003451713 no 747 0.202914323953668 1011 2731748
SGTC_3187 9109394 49.47 µM 0.830150442357377 0.211226708677953 no 748 0.203226865259072 1006 17098090
SGTC_2772 vinpocetine 57.06 µM 0.830050311027524 0.21125520816265 no 749 0.203255169475159 956 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2776 terbinafine 19.92 µM 0.828029498599311 0.211830855288402 no 750 0.203826897120469 1022 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1369 1866-0067 208 µM 0.826924580552293 0.212145989118184 no 751 0.204139905127209 1053 3531355
SGTC_1162 k048-0130 20.1 µM 0.826687269578503 0.21221370835273 no 752 0.204207169374653 981 6797406
SGTC_3211 9128781 49.47 µM 0.826665759601636 0.212219847080117 no 753 0.204213266889614 910 17194361
SGTC_1190 1486-1332 13 µM 0.826198012628565 0.212353362950885 no 754 0.204345887715925 995 4150046
SGTC_533 1222-0222 6.71 µM 0.826176976137608 0.212359368857904 no 755 0.204351853420538 1041 3982874
SGTC_2828 7998861 71.43 µM 0.825981562747315 0.212415164020714 no 756 0.204407275344312 928 2988188
SGTC_2052 5265182 7.135 µM 0.823889341571866 0.213013079414333 no 757 0.205001218550556 1005 1239884
SGTC_430 0958-0115 16.4 µM 0.823164676047873 0.213220403215821 no 758 0.205207176762757 942 6833180
SGTC_1121 fusaric acid 630.51 nM 0.822993088218197 0.213269511007307 no 759 0.205255961978223 981 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3217 9129673 49.47 µM 0.822484150673778 0.213415205802673 no 760 0.205400701735409 966 17248312
SGTC_627 1391-0720 175 µM 0.818923562247676 0.214436125714758 no 761 0.206415012876932 976 997839
SGTC_2853 9015042 58.44 µM 0.818501068073334 0.214557454761142 no 762 0.206535566202999 997 6457456
SGTC_2630 antimycin a 100 µM 0.818190601171095 0.214646637997732 no 763 0.206624180553461 1077 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2892 9047358 58.44 µM 0.816665789256059 0.215084960810963 no 764 0.207059723477683 957 6466771
SGTC_1352 1496-0991 99 µM 0.816494255309112 0.215134302499902 no 765 0.207108753910754 1039 3000039
SGTC_813 k007-0158 173 µM 0.816453498529094 0.215146027141636 no 766 0.207120404641204 1074 6523916
SGTC_349 k015-0014 24 µM 0.81605632454854 0.215260302951971 no 767 0.207233961065886 946 2196908
SGTC_1900 st060200 72.8 µM 0.813038379684663 0.216129783013586 no 768 0.208098026944883 1003 688945
SGTC_2796 7949634 45.45 µM 0.812542526111134 0.216272834386212 no 769 0.208240197577113 956 2971588
SGTC_390 dec-rvkr-cmk 16.7 µM 0.811978344081675 0.216435664836727 no 770 0.208402028952712 1048 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2844 9010103 25.97 µM 0.811849108014473 0.216472974072291 no 771 0.208439109786535 972 2480525
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.811059957917203 0.216700875004322 no 772 0.208665619712793 1103 91467 include heat shock
SGTC_1152 3909-8331 15.9 µM 0.808432134525259 0.217460771332921 no 773 0.209420929676484 990 16001939
SGTC_2902 5787006 60.46 µM 0.807528953015421 0.217722302088813 no 774 0.209680900320297 989 591003
SGTC_2357 9067248 200 µM 0.806924089012272 0.217897551613644 no 775 0.209855109677446 990 9150235
SGTC_1670 st016595 4.04 µM 0.806373663859478 0.218057099036957 no 776 0.210013713790465 1076 597879
SGTC_412 gemfibrozil 100 µM 0.805422016412163 0.218333104428448 no 777 0.210288095552005 997 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3142 9086498 49.47 µM 0.804213058975073 0.218684027252701 no 778 0.210636969074152 988 25236367
SGTC_2687 chenodiol 100 µM 0.803408420266663 0.218917768729737 no 779 0.210869354885856 985 5702181 A cholesterol synthesis inhibitor.
SGTC_3170 9103054 49.47 µM 0.802813677949938 0.219090629223125 no 780 0.211041217604992 990 16432970
SGTC_3299 9121982 43.1275 µM 0.802423164737835 0.219204173667942 no 781 0.211154108870342 1054 17594604 YPL160W CDC60
SGTC_1480 1070-0044 41.2 µM 0.802370037749911 0.21921962332448 no 782 0.211169469786325 1063 3124987
SGTC_3218 9131285 49.47 µM 0.802076720386578 0.219304933094251 no 783 0.211254290134142 1065 17156417
SGTC_1737 st035557 69.7 µM 0.801899294053793 0.219356545844058 no 784 0.211305607262403 903 5716916
SGTC_231 b-estradiol 524 µM 0.801812264673317 0.219381864962466 no 785 0.211330781493341 987 450 A steroid.
SGTC_538 2922-0838 53.3 µM 0.801782032965635 0.219390660548302 no 786 0.211339526767249 1090 777039
SGTC_3033 9090887 49.47 µM 0.801074973533607 0.219596429562979 no 787 0.211544121756156 1068 19325384
SGTC_3059 1327-0034 3 µM 0.800968423347732 0.219627447492286 no 788 0.211574963209996 1002 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1632 st005650 90 µM 0.798748772968875 0.220274184000574 no 789 0.212218049863652 1011 2759605
SGTC_2359 9039622 200 µM 0.798433115198271 0.220366245377258 no 790 0.21230959629954 1055 6463596
SGTC_573 3702-0553 84.7 µM 0.797524011224304 0.220631508138308 no 791 0.212573381735748 1023 1222756
SGTC_2096 5468907 200 µM 0.797224420559086 0.22071896420986 no 792 0.212660352823525 1063 759785
SGTC_3306 9127676 59.7925 µM 0.796842303610968 0.220830540040992 no 793 0.212771311415129 1030 41905287
SGTC_2921 7974240 10.71 µM 0.796439724598569 0.220948125598854 no 794 0.212888248305805 1014 2979074 YDR527W RBA50
SGTC_615 k087-0205 167 µM 0.794623850507442 0.221478952572017 no 795 0.21341617013793 1030 9642773
SGTC_1145 3546-0597 10.2 µM 0.794572236095561 0.221494051448192 no 796 0.213431186934937 1023 875334
SGTC_597 k018-0003 82.8 µM 0.788303366644275 0.223332268325735 no 797 0.215259639444404 1140 6786234
SGTC_1273 0849-0096 14.1 µM 0.78554848980435 0.224142817082566 no 798 0.216066025943129 1032 5286025
SGTC_2383 9036125 200 µM 0.783796853086677 0.224659056963587 no 799 0.216579660335812 1034 79580
SGTC_1788 fluconazole 20 µM 0.783768868991734 0.22466730986572 no 800 0.216587871871781 987 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.782998711822077 0.224894507496081 no 801 0.216813934253428 1120 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_688 0527-0193 473 µM 0.78221766192553 0.225125051459694 no 802 0.217043333221358 1028 4007154
SGTC_2556 citropten 84.59 µM 0.78143168800214 0.225357183962082 no 803 0.21727431992783 1099 2775 A potential DNA crosslinker.
SGTC_2790 5423970 71.43 µM 0.780867165174394 0.225523995859286 no 804 0.217440312836725 1078 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3175 9106517 49.47 µM 0.780310275142041 0.225688620780613 no 805 0.217604133101232 1037 41468073
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.77942732438763 0.225949773366616 no 806 0.217864016537886 1060 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3354 9151612 71.43 µM 0.776307140214799 0.226874005569855 no 807 0.218783829088422 1083 27261949
SGTC_608 k048-0125 159 µM 0.774311742630345 0.227466180063105 no 808 0.219373230600386 1103 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_127 0180-0333 59.125 µM 0.773510204270181 0.227704297612187 no 809 0.219610246017473 1091 771601
SGTC_2331 7980721 200 µM 0.773174578635488 0.227804045486071 no 810 0.219709534402335 1080 2981221
SGTC_1804 st050076 49.1 µM 0.773033043931146 0.227846116943135 no 811 0.219751412445593 1051 3895976
SGTC_222 nsc-310342 10.666 µM 0.771052389959742 0.228435328560205 no 812 0.220337939490918 1041 432556
SGTC_2938 9059746 27.26 µM 0.770272483763091 0.228667572396933 no 813 0.220569137566338 1020 6471769
SGTC_1927 st060202 13.8 µM 0.769366631221165 0.228937487436234 no 814 0.220837846002908 1068 688887
SGTC_1070 indatraline 8.81 µM 0.767154139716916 0.229597490055007 no 815 0.221494937918235 1073 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_126 0417-1624 672.48 µM 0.766853522685019 0.229687248526619 no 816 0.221584304889242 1218 41912 YDL195W SEC31
SGTC_1433 4060-0023 7.6 µM 0.7665855631112 0.229767272672697 no 817 0.221663980869386 1094 3840627
SGTC_1297 1068-0111 14.1 µM 0.765294681794222 0.230153003530632 no 818 0.222048045081651 1070 767057
SGTC_1016 4226-1401 38 µM 0.765123808139863 0.230204089769101 no 819 0.222098912026143 1113 2901613
SGTC_1011 4112-3381 17.4 µM 0.764773446842253 0.230308857410468 no 820 0.222203230989842 1089 2877139
SGTC_308 4092-1169 104 µM 0.764103419800163 0.230509288112727 no 821 0.222402807260584 1103 2268590 YDL196W YDL196W
SGTC_391 gliotoxin 8.33 µM 0.763371472583799 0.230728352884246 no 822 0.222620944066646 1108 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1000 4048-0884 8.67 µM 0.763096788723177 0.230810593126353 no 823 0.222702837526713 1046 13040088
SGTC_266 formosanin C 406 nM 0.761740843320981 0.231216802441358 no 824 0.223107346699474 1097 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3184 9108758 49.47 µM 0.758348987101908 0.23223466733203 no 825 0.224121044117742 1088 902885
SGTC_928 2764-0428 58.7 µM 0.758094675856879 0.232311084152621 no 826 0.224197153396336 1093 662578
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.756864044161191 0.232681068601791 no 827 0.224565659339594 1049 2374 Ca(2+)-ATPase inhibitor.
SGTC_2368 9071271 200 µM 0.756345540039782 0.232837052783509 no 828 0.224721025403118 1093 27209959
SGTC_258 haloperidol 50.781 µM 0.755120297135523 0.233205879466455 no 829 0.22508840282252 1094 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1271 0832-2808 169 µM 0.754289797505207 0.233456063510319 no 830 0.225337613612417 1130 3663794
SGTC_1132 3456-3614 2.5 µM 0.753918956333802 0.233567825705259 no 831 0.225448943596437 1172 3125502
SGTC_1180 1193-0155 285 µM 0.753236231459821 0.233773659370088 no 832 0.225653985388456 1095 2921347
SGTC_102 gallobenzophenone 83.616 µM 0.752745689928359 0.233921614024611 no 833 0.225801374147624 1096 70837
SGTC_476 mead acid 10 µM 0.75052384509478 0.23459240486038 no 834 0.226469634001921 1117 5312531 An omega 9 fatty acid.
SGTC_1581 himbacine 57.9 µM 0.749635262937349 0.234860971688465 no 835 0.226737203381231 1079 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1911 st060208 74.3 µM 0.74712368973139 0.235620992704328 no 836 0.227494450800548 1120 688783
SGTC_2032 5185112 25.99 µM 0.745521510601664 0.236106532073114 no 837 0.227978256145195 1065 5718189
SGTC_45 0kpi-0036 14.9 µM 0.745148688527465 0.236219594569259 no 838 0.228090919087732 1093 2795021
SGTC_1514 1189-1591 158 µM 0.745003913508617 0.236263507261838 no 839 0.228134677026878 1130 767698 YMR146C TIF34
SGTC_2155 5570423 76 µM 0.744073854065243 0.236545717070691 no 840 0.228415898038301 1065 797402
SGTC_1146 3579-1023 7 µM 0.743871551190713 0.236607126791711 no 841 0.228477093909809 1153 X1146
SGTC_1666 st014829 29 µM 0.742449687447341 0.237038985707798 no 842 0.228907462213109 1153 3858230
SGTC_2739 tacrine 100.86 µM 0.741966566435825 0.237185821314369 no 843 0.22905379628541 1135 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1129 3453-1384 223 µM 0.738494842121231 0.238242455355683 no 844 0.230106900168992 1145 1084452
SGTC_2482 5981709 142.65 µM 0.737718126144743 0.23847920466697 no 845 0.230342877467895 1091 877755
SGTC_2451 5856223 45.7 µM 0.737422671649428 0.23856929539154 no 846 0.230432676235487 1113 2179896
SGTC_399 oxolinic acid 75 µM 0.736735747792825 0.23877882591849 no 847 0.230641531610856 1094 4628 A DNA gyrase inhibitor.
SGTC_2292 7671323 168.05 µM 0.735224332102379 0.239240203187964 no 848 0.23110144130241 1126 937504
SGTC_147 4466-0538 29.23 µM 0.731048944596516 0.24051731665749 no 849 0.232374628849204 1252 6742687 YHR072W ERG7
SGTC_2808 7946468 45.46 µM 0.730829571533931 0.240584518141272 no 850 0.232441629285351 1124 2970879
SGTC_1649 st011737 51.3 µM 0.729213815565889 0.241079794318969 no 851 0.232935440751695 1103 1761035
SGTC_1873 rapamycin 2 nM 0.726239405386918 0.241992985269103 no 852 0.23384600942745 1139 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1289 0976-0073 69.1 µM 0.722257043185751 0.243218565185579 no 853 0.235068229050095 1176 3391136
SGTC_748 act1.228 77.9 µM 0.721584759638823 0.243425792327545 no 854 0.235274905961652 1140 4421505 YNR035C ARC35
SGTC_804 1595-0054 20.9 µM 0.7205478508145 0.243745599845337 no 855 0.235593874483028 1109 761523 Stimulates phospholipase C.
SGTC_3188 9110789 49.47 µM 0.719844729569358 0.243962588256284 no 856 0.23581030064885 1180 849217
SGTC_1712 st032288 53.4 µM 0.716964041697928 0.244852676931348 no 857 0.236698142168046 1171 2883011
SGTC_845 0330-0138 4.51 µM 0.71427196620301 0.245686064569283 no 858 0.237529511792076 1142 9039800
SGTC_1483 3453-0561 55.9 µM 0.711566508343677 0.246525127137369 no 859 0.238366626274663 1168 4546991
SGTC_822 1487-0950 154 µM 0.708319673750045 0.247534113955325 no 860 0.239373381190091 1179 1958375
SGTC_855 0428-0020 25 µM 0.706385248018084 0.248136303591034 no 861 0.239974296145271 1161 6812414
SGTC_948 3448-0295 75.3 µM 0.705660198920304 0.248362213625338 no 862 0.240199739017005 1205 678569
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.704775878820935 0.248637897486844 no 863 0.240474860927327 1102 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1920 st075728 45.7 µM 0.704468069028302 0.248733894397146 no 864 0.240570664256682 1172 3400306
SGTC_2711 st079103 59.1 µM 0.703975852326475 0.248887443457025 no 865 0.240723905931193 1178 54693780
SGTC_288 1315-0019 35.1 µM 0.703319463493288 0.249092285177165 no 866 0.240928341895067 1209 6811474
SGTC_466 geldanamycin 89.2 µM 0.702409668287534 0.249376356611368 no 867 0.241211858778773 1082 5288382 HSP90 inhibitor.
SGTC_2583 asiatic acid 100 µM 0.701511368561616 0.249657007599066 no 868 0.241491971177922 1216 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3020 9089140 49.47 µM 0.701178403907506 0.249761076567343 no 869 0.241595842773691 1200 17217859
SGTC_2729 fluphenazine 10.66 µM 0.700695955347349 0.249911907977519 no 870 0.241746390371845 1146 3372 An atypical antipsychotic.
SGTC_2723 salbutamol 83.58 µM 0.700134607994108 0.250087466925911 no 871 0.241921622327754 1151 9884233 β2-adrenoceptor agonist
SGTC_1696 st025591 34.7925 µM 0.699297907022851 0.250349262909843 no 872 0.242182937379849 1210 2787147
SGTC_2476 5806916 10.51 µM 0.69837606754336 0.250637866063861 no 873 0.242471019618241 1124 2870194
SGTC_1730 st033808 45.1 µM 0.698056565706209 0.250737934606854 no 874 0.242570909807588 1196 1045166
SGTC_1806 st050005 60.3 µM 0.696874875835 0.251108225724047 no 875 0.242940551082592 1171 5194765
SGTC_2452 5863136 48.41 µM 0.696453338405958 0.25124038751123 no 876 0.24307248479227 1173 2184096
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.696257197421427 0.251301894808044 no 877 0.243133886634956 1213 115019
SGTC_2008 4012253 172 µM 0.694107304235048 0.251976595266667 no 878 0.243807459127415 1225 603940
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.693051720715075 0.252308218342266 no 879 0.244138547115521 1151 6857784
SGTC_88 0180-0332 8.668 µM 0.691643100213434 0.252751109978429 no 880 0.244580743942202 1251 3101745
SGTC_304 1310-0298 97 µM 0.691538375628913 0.252784053315665 no 881 0.244613636502178 1154 1550234
SGTC_2167 5876490 200 µM 0.691377868027817 0.252834548770193 no 882 0.244664054368331 1220 686534
SGTC_1239 0337-0584 35.4 µM 0.689688226214231 0.253366429587203 no 883 0.245195135766019 1246 914301 YML130C ERO1
SGTC_1513 0337-0559 19 µM 0.688706219756078 0.253675824535165 no 884 0.245504080660036 1143 775073
SGTC_943 3253-1379 105 µM 0.687190537866065 0.254153750615819 no 885 0.245981333130726 1203 668464
SGTC_1573 oleylamine 1.06 µM 0.687027855046765 0.254205075947067 no 886 0.246032587678622 1231 5356789 An amine of the fatty acid oleic acid.
SGTC_3107 9121808 49.47 µM 0.685843778747746 0.25457880771022 no 887 0.246405813115561 1162 662681
SGTC_3346 9158254 43.5805 µM 0.684696905109457 0.254941071351862 no 888 0.246767601208166 1175 17639500
SGTC_156 3474-0145 5.642 µM 0.683272451841128 0.255391389534684 no 889 0.247217349128758 1162 2265471
SGTC_2207 7258803 200 µM 0.681668455361742 0.255898964590146 no 890 0.247724309097336 1175 3666799
SGTC_2029 5175081 200 µM 0.681555419983941 0.255934753802617 no 891 0.247760056045423 1224 1380876
SGTC_3215 9129942 49.47 µM 0.679007035755836 0.256742314786085 no 892 0.248566701995326 1163 17682944
SGTC_1972 st070201 17.4 µM 0.678465477255867 0.256914100748205 no 893 0.24873830283857 1210 2829099
SGTC_3288 9119690 36.221 µM 0.677708203777797 0.257154413185593 no 894 0.24897836191049 1201 17595618 YKL019W RAM2
SGTC_1558 st069300 45.6 µM 0.677519738664115 0.257214238682271 no 895 0.249038125346467 1173 24208000
SGTC_363 0455-0021 3.06 µM 0.677015956730036 0.257374192410923 no 896 0.249197915129652 1243 4597466
SGTC_1135 dihydrocapsaicin 536.708 nM 0.67686301829935 0.257422761488328 no 897 0.249246434997382 1192 107982 A Capsaicinoid.
SGTC_3183 9108214 49.47 µM 0.672170306985986 0.258915350210301 no 898 0.250737640899969 1149 4974831
SGTC_2924 9010168 62.78 µM 0.671910301441638 0.258998179662938 no 899 0.250820400939887 1260 2993929
SGTC_2388 9080168 200 µM 0.671882279269147 0.259007107449104 no 900 0.250829321290264 1198 15943073
SGTC_778 3456-2434 196 µM 0.67085258153232 0.259335276625319 no 901 0.251157223331167 1276 5539063
SGTC_1183 1254-0324 198 µM 0.670736961674492 0.259372138591472 no 902 0.25119405604362 1251 5799357
SGTC_2791 5663188 71.43 µM 0.670110589063657 0.259571885986125 no 903 0.251393647559529 1217 54690634
SGTC_311 1315-0136 58 µM 0.669504848263962 0.259765129507227 no 904 0.251586744518273 1275 6759207
SGTC_1078 idebenone 36.1 µM 0.669301611690889 0.259829982698296 no 905 0.251651549456574 1246 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2522 biochanin a 4.94 µM 0.669257979732345 0.259843906831417 no 906 0.251665463290897 1199 5280373 A possible chelator.
SGTC_2988 9073640 71.4286 µM 0.667600054647905 0.26037328046793 no 907 0.252194461411071 1264 9102229
SGTC_2948 9070189 9.45 µM 0.665717573477299 0.260975027413094 no 908 0.252795819365248 1164 6473636 YDL196W YDL196W
SGTC_2499 avocadenofuran 51.48 µM 0.665054462323518 0.261187165251359 no 909 0.253007829654791 1203 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_684 1140-0066 328 µM 0.664147378266618 0.261477496628178 no 910 0.253297994553492 1244 6813534
SGTC_451 chloral hydrate 100 µM 0.662256003245329 0.2620834036045 no 911 0.253903584142043 1306 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1834 st055981 52.8 µM 0.661226082631561 0.262413643742712 no 912 0.254233668364755 1298 471719 YDL150W RPC53
SGTC_3189 9110682 49.47 µM 0.660031638498537 0.262796904384292 no 913 0.254616763128341 1290 17122418
SGTC_303 1348-1668 34.2 µM 0.658249073574373 0.263369406982871 no 914 0.255189048038561 1265 5380509
SGTC_2267 7931562 200 µM 0.657269591059061 0.263684256167869 no 915 0.255503792841504 1192 934880
SGTC_2463 5473429 200 µM 0.656258617390842 0.264009429242631 no 916 0.255828869514585 1233 5399405
SGTC_1484 3473-2379 286 µM 0.655521115021783 0.264246770904563 no 917 0.256066148118834 1354 671917
SGTC_2398 5228213 48.84 µM 0.654795994493523 0.264480233753029 no 918 0.256299554947148 1272 80771 YMR134W ERG29
SGTC_2190 6049624 200 µM 0.654745385056381 0.264496532097584 no 919 0.256315849603164 1204 2265554
SGTC_1560 lithocholic acid 53.1 µM 0.653657049483097 0.264847145061982 no 920 0.256666390237912 1214 9903 A bile acid which acts as a detergent.
SGTC_324 1315-0088 19.6 µM 0.649256591443812 0.266267180177239 no 921 0.258086269218804 1211 6787421
SGTC_817 1391-0715 46 µM 0.649213616918263 0.266281067105841 no 922 0.258100155701062 1236 1353946
SGTC_2421 5690543 90.72 µM 0.649179210751613 0.266292185491171 no 923 0.258111273744086 1297 3397993
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.649065013370184 0.266329090167155 no 924 0.25814817737982 1278 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2114 5491910 81.25 µM 0.648826435685613 0.266406198641162 no 925 0.2582252841562 1317 2849228
SGTC_762 1165-0429 115 µM 0.648109066534771 0.266638120871771 no 926 0.258457205158208 1281 5967793
SGTC_1808 st050063 61.5 µM 0.647232656118086 0.266921598897339 no 927 0.258740689579222 1282 4011993
SGTC_389 tpck 16.7 µM 0.644382067424986 0.267844683485744 no 928 0.259663855061723 1257 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2710 st078562 53.7235 µM 0.643325106996679 0.268187359192156 no 929 0.260006584136668 1247 17250908
SGTC_1003 4049-0218 100 µM 0.642324630577533 0.268511925412248 no 930 0.260331212529358 1315 295161
SGTC_1926 methyl fluorone black 53.6 µM 0.642052417739055 0.268600268591828 no 931 0.260419574587362 1141 72721 Reacts with homocysteine.
SGTC_39 0986-0283 58.349 µM 0.635385296406704 0.270768547033096 no 932 0.262588577692628 1327 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2669 eugenol 100 µM 0.635189090541863 0.270832489139709 no 933 0.26265254876555 1274 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1835 st008666 49.2 µM 0.633238776988229 0.271468492071396 no 934 0.263288863400804 1252 690455
SGTC_1044 1222-0021 1.78 µM 0.633011045450891 0.271542804469469 no 935 0.26336321501298 1290 4306703
SGTC_442 cape 100 µM 0.632433562401508 0.271731291717586 no 936 0.26355180434259 1296 5281787
SGTC_1256 0570-0116 285 µM 0.632066843062264 0.271851020663916 no 937 0.263671600081453 1270 410638
SGTC_3117 9124945 49.47 µM 0.631106243719147 0.272164767841695 no 938 0.263985529465232 1208 17592065
SGTC_534 k292-0788 63.4 µM 0.630840066277706 0.272251737505974 no 939 0.264072551474202 1347 4146317
SGTC_719 2810-4230 27.3 µM 0.63017944639626 0.272467645237719 no 940 0.264288592600258 1279 721079
SGTC_3252 9135871 49.47 µM 0.624267831287767 0.274403491094753 no 941 0.266225853203607 1320 17682838
SGTC_1813 st051246 8.6015 µM 0.623639490991637 0.274609648860116 no 942 0.266432184737646 1261 5291959
SGTC_2619 obliquin 87.91 µM 0.621862614054101 0.275193053422259 no 943 0.267016105050178 1307 6708593 A bioactive alkalod. YER133W GLC7
SGTC_564 3555-0129 330 µM 0.6216193124268 0.275272984469665 no 944 0.267096109518794 1219 563260
SGTC_616 4092-0450 108 µM 0.620330093306816 0.275696717806247 no 945 0.267520243167242 1338 787165
SGTC_2899 9053889 58.44 µM 0.61989842070436 0.275838669162517 no 946 0.267662332796776 1291 6470052
SGTC_3179 9107801 49.47 µM 0.618488941538606 0.276302412645964 no 947 0.268126542565358 1297 4818259
SGTC_10 0279-0212 42.575 µM 0.617888190772448 0.27650018642977 no 948 0.268324521979398 1315 39851 YBR002C RER2
SGTC_937 3122-0005 46.7 µM 0.617336954651033 0.276681720488915 no 949 0.268506248343882 1300 759535
SGTC_2070 5230947 200 µM 0.617058215593074 0.276773537558347 no 950 0.268598163975005 1365 2835538
SGTC_1980 st071811 45.7 µM 0.616622249855101 0.276917175258477 no 951 0.268741957610253 1357 4974850
SGTC_1988 st071872 53.4 µM 0.615400433618944 0.277319921629744 no 952 0.269145152559686 1331 16414116
SGTC_769 0302-0231 76 µM 0.614814464588462 0.277513175740103 no 953 0.269338627850856 1326 571869 YER009W NTF2
SGTC_2132 5317594 122.667 µM 0.614484147179498 0.27762214428107 no 954 0.269447722802266 1343 794577
SGTC_1428 4049-0204 61.7 µM 0.614400988577625 0.277649580798573 no 955 0.269475191340413 1383 X1428
SGTC_867 0518-0118 155 µM 0.61393853732111 0.277802181501358 no 956 0.269627971553442 1346 6848158
SGTC_103 0844-0104 51.839 µM 0.613590553624302 0.277917036936941 no 957 0.269742963677025 1346 5375804
SGTC_2713 st079149 53.4 µM 0.612235638739525 0.278364460577009 no 958 0.27019093270811 1344 3103253
SGTC_183 3914-0051 30.55 µM 0.611938555571034 0.27846261108703 no 959 0.270289205606435 1328 1596232
SGTC_106 0092-0003 11.579 µM 0.611582596936247 0.278580235108598 no 960 0.270406977599355 1323 1072148
SGTC_2689 tacrolimus 100 µM 0.611529722159218 0.278597709269931 no 961 0.27042447386417 1335 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1443 4112-3303 14 µM 0.611218911540258 0.278700437370639 no 962 0.270527332540445 1315 704433
SGTC_2941 9056145 11.23 µM 0.61098642414271 0.278777290392846 no 963 0.27060428395551 1229 2119517
SGTC_2944 9067346 25.62 µM 0.610806034666109 0.278836928586746 no 964 0.270663998919174 1307 6473075
SGTC_1390 3413-2614 145 µM 0.609760888865674 0.279182584231212 no 965 0.271010106676176 1322 3421432
SGTC_2916 7875993 68.79 µM 0.609485012802981 0.279273858022106 no 966 0.271101501889857 1352 1299250
SGTC_341 1486-1430 230 µM 0.607221653612327 0.280023239030205 no 967 0.27185191194671 1279 2054753 YPL210C SRP72
SGTC_626 0214-0009 33 µM 0.607001153050462 0.28009629716447 no 968 0.271925073465307 1399 3437874
SGTC_542 3381-0244 89.3 µM 0.606789256810439 0.280166513144174 no 969 0.271995389319246 1364 1112843
SGTC_567 1080-0542 68.4 µM 0.606488821380563 0.280266082939575 no 970 0.272095101601132 1281 5950415
SGTC_554 4483-2211 187 µM 0.606145196968032 0.280379987363218 no 971 0.272209170260555 1324 747107
SGTC_2810 7959871 45.46 µM 0.605830480479629 0.280484329066492 no 972 0.272313663568503 1358 2974535
SGTC_344 k064-0035 6.43 µM 0.60577797457228 0.280501738804157 no 973 0.272331098709548 1293 5088750
SGTC_703 3875-0075 71.8 µM 0.605486742414686 0.280598314109028 no 974 0.272427815491045 1383 2850814
SGTC_1874 staurosporine 7.6 µM 0.604796462503739 0.280827281614533 no 975 0.272657122202343 1364 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1816 st051957 91.6 µM 0.601947601952296 0.281773210075888 no 976 0.273604508316802 1344 674121
SGTC_1413 3910-0535 34.4 µM 0.601081998729672 0.282060926684948 no 977 0.27389268623198 1389 2876951
SGTC_1310 1188-0297 994 nM 0.600915068051937 0.282116428800104 no 978 0.273948278296708 1291 1588352
SGTC_1830 st055982 50.3 µM 0.600505836183375 0.282252514912798 no 979 0.274084586272017 1308 455313 An antimicrobial agent.
SGTC_1082 camptothecin 424.86 nM 0.59895759103872 0.282767654555613 no 980 0.27460058264816 1257 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1282 0886-0010 32.4 µM 0.598704917144749 0.282851768293478 no 981 0.274684838812207 1391 2836211 YNL267W PIK1
SGTC_2661 dactinomycin 12.96 µM 0.597390717028247 0.283289451911526 no 982 0.275123275013393 1344 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2847 9005661 71.43 µM 0.596098492225508 0.283720133287711 no 983 0.275554715692707 1263 2991449
SGTC_863 0466-0191 129 µM 0.595359053593924 0.283966719339363 no 984 0.275801744845955 1342 765160 YPR165W RHO1
SGTC_2079 5212404 121 µM 0.594299753310341 0.284320150597145 no 985 0.276155821804415 1386 758462
SGTC_3001 9076041 71.4286 µM 0.593894347073925 0.28445546835537 no 986 0.276291390084723 1343 16004211
SGTC_811 0416-0114 265 µM 0.592270356460476 0.284997837263588 no 987 0.276834781445485 1355 6612453
SGTC_2227 7312221 64.1025 µM 0.5896661710474 0.285868592717386 no 988 0.277707239643634 1362 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_668 1682-0499 62.6 µM 0.588906641147873 0.286122793033888 no 989 0.277961951238748 1377 682214
SGTC_670 4204-0025 119 µM 0.588319677220474 0.28631931230739 no 990 0.278158870164042 1397 719039
SGTC_400 oxethazaine 37.5 µM 0.588027753358671 0.286417074136032 no 991 0.278256832230406 1341 4621 A local anesthetic.
SGTC_1705 st027868 56.3335 µM 0.586882189715103 0.286800862754458 no 992 0.278641416072172 1358 292948
SGTC_2512 diallyl trisulfide 49.23 µM 0.581931884827615 0.28846211830511 no 993 0.280306281290108 1336 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1251 0490-5699 265 µM 0.580977143802473 0.28878303745638 no 994 0.280627929004321 1400 3883818
SGTC_2346 9031566 143.75 µM 0.579873217662605 0.289154311919512 no 995 0.281000058931616 1391 4771086
SGTC_2411 st077133 39.94 µM 0.578630299568358 0.28957260081685 no 996 0.281419327764382 1510 1403142 YNL221C POP1
SGTC_2588 indole-3-carbinol 100 µM 0.578465426036588 0.28962810832513 no 997 0.281474966595404 1418 3712 Induces cell cycle arrest.
SGTC_1781 st038725 66.3 µM 0.578389005620148 0.289653838265812 no 998 0.28150075751138 1376 4270275 YIL048W NEO1
SGTC_667 1498-1044 59 µM 0.57588387718794 0.290497881779063 no 999 0.282346837021646 1408 6739982
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.573656892917123 0.291249176334491 no 1000 0.283100002102713 1425 364106
SGTC_2397 5161689 200 µM 0.572399268244051 0.291673848451779 no 1001 0.283525755744202 1448 2259942
SGTC_755 1995-0008 37.3 µM 0.571913242036779 0.291838046074111 no 1002 0.283690376209972 1373 689533
SGTC_751 0833-0568 350 µM 0.571182125949825 0.292085125194107 no 1003 0.283938096519873 1405 6954252
SGTC_294 k038-0071 157 µM 0.570917473985204 0.292174587755323 no 1004 0.284027792696984 1372 24152826
SGTC_2235 salicylic acid 500 µM 0.568895579723098 0.29285848633301 no 1005 0.284713502651579 1396 338 A COX inhibitor and kinase inhibitor.
SGTC_773 4358-1457 44.6 µM 0.568533173526225 0.292981147435348 no 1006 0.284836493397431 1439 1186886
SGTC_41 0478-0632 82.643 µM 0.565466281883688 0.294020130028868 no 1007 0.285878326134776 1395 3750424
SGTC_1345 1488-0192 31.4 µM 0.565345403110181 0.294061115460806 no 1008 0.285919426119695 1388 658348
SGTC_1199 1638-0010 4.46 µM 0.5651937983469 0.294112522649467 no 1009 0.285970977217088 1373 3111136
SGTC_531 3788-1495 174 µM 0.564882364961501 0.294218138656627 no 1010 0.286076889677897 1372 2896655
SGTC_3105 9121040 49.47 µM 0.564520755612994 0.294340792752493 no 1011 0.286199889390443 1277 41448907
SGTC_1238 0333-0287 48.8 µM 0.564203829644987 0.294448310126064 no 1012 0.286307710910979 1382 7226
SGTC_1968 st069590 43.6 µM 0.564016753205776 0.294511784456896 no 1013 0.28637136531759 1381 6384066
SGTC_421 streptovitacin 30 mM 0.563353252724125 0.294736958568111 no 1014 0.286597181347922 1417 91467 include heat shock
SGTC_1457 k015-0032 57.3 µM 0.561948580783108 0.29521392796904 no 1015 0.287075526450594 1387 4302660
SGTC_2845 9003024 42.97 µM 0.561507559267772 0.295363754180974 no 1016 0.287225789273082 1473 2990173
SGTC_2778 tioconazole 65.09 nM 0.560779939172609 0.295611021657231 no 1017 0.287473781986095 1351 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1683 st010134 710 nM 0.557592979416085 0.296695167140319 no 1018 0.28856117579885 1370 3818134
SGTC_72 0744-0168 198.391 µM 0.556471016944706 0.297077271126187 no 1019 0.288944451181159 1434 677577
SGTC_2537 larixol 68.93 µM 0.556152412216048 0.297185818561671 no 1020 0.289053333901341 1395 6708759
SGTC_2886 9058944 51.95 µM 0.553793492626191 0.297990057027636 no 1021 0.289860091144979 1318 4949929
SGTC_1274 0865-0114 173 µM 0.551576141533018 0.29874693302481 no 1022 0.290619393176822 1426 870624
SGTC_2181 6316240 54.2555 µM 0.551251134486153 0.298857945104858 no 1023 0.290730765608834 1375 12779990
SGTC_1662 st014054 52 µM 0.550716707475183 0.299040529127487 no 1024 0.290913944822512 1395 2838777
SGTC_2654 protoveratrine a 100 µM 0.550617164301654 0.299074543095121 no 1025 0.290948070014661 1394 5702278 A heart drug and vasodilator.
SGTC_2656 pseudo-anisatin 100 µM 0.549464655472846 0.299468483943812 no 1026 0.291343306926665 1409 6708809 A neurotoxin.
SGTC_901 1112-0062 60.1 µM 0.54928453890458 0.299530071119124 no 1027 0.291405098035529 1411 1908457
SGTC_675 1309-0189 238 µM 0.548729500170855 0.299719891349617 no 1028 0.291595549047385 1376 4246530
SGTC_2249 haloperidol 116.36 µM 0.547319370417366 0.300202392935306 no 1029 0.292079669149537 1428 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_271 rotenone 740 µM 0.546939882025764 0.300332301750995 no 1030 0.292210017444045 1442 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_844 0330-0132 15.3 µM 0.546926257391604 0.300336966292511 no 1031 0.292214697794848 1438 2828079
SGTC_177 1327-0068 8.361 µM 0.543324016819896 0.301571379210134 no 1032 0.293453365551353 1400 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1668 st014914 51.6 µM 0.541487569687603 0.302201568569614 no 1033 0.294085781562431 1419 2839556
SGTC_692 k241-0027 77.8 µM 0.539664880391809 0.302827620581923 no 1034 0.294714081943411 1508 3600480
SGTC_967 1306-0166 352 µM 0.539222833614069 0.302979540978825 no 1035 0.294866553388327 1472 4437607
SGTC_516 3992-2719 87.3 µM 0.539013854922245 0.303051373588361 no 1036 0.294938647290398 1338 5350887 YDR037W KRS1
SGTC_2809 7964133 12.99 µM 0.537093022299416 0.303711981275764 no 1037 0.295601680205667 1457 1253665
SGTC_1902 st060212 70.5 µM 0.536809072156938 0.303809691160208 no 1038 0.295699752207251 1432 688944
SGTC_1158 4092-0494 91.8 µM 0.536699326342734 0.303847459472644 no 1039 0.295737660725513 1521 1148199
SGTC_1539 benzyladenosine 56 µM 0.535378775915811 0.304302082481027 no 1040 0.296193981676401 1403 92208 A nucleotide analog.
SGTC_3333 9141820 12.094 µM 0.535197587035457 0.304364483605489 no 1041 0.296256617336887 1426 1939433
SGTC_1410 3909-8106 77.9 µM 0.535110901449032 0.30439433998014 no 1042 0.296286586053482 1476 1039210
SGTC_1540 guanosine 70.6 µM 0.535036985263512 0.304419799329081 no 1043 0.296312141263933 1402 6802 Guanosine is a purine nucleoside
SGTC_319 1348-1596 45.5 µM 0.534919851105017 0.304460146417641 no 1044 0.296352640391977 1523 5380505
SGTC_136 0097-0015 404.482 µM 0.533840522400411 0.304832035226313 no 1045 0.296725937596439 1444 4861337
SGTC_3327 9140648 26.9345 µM 0.533248750637822 0.305036019181105 no 1046 0.296930699435103 1456 8029710
SGTC_1445 4239-0156 97.7 µM 0.532247156951444 0.305381406953751 no 1047 0.297277412987809 1574 4008346
SGTC_2516 gossypol 71.55 µM 0.531403659544996 0.305672411551573 no 1048 0.297569543055485 1525 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_169 k015-0017 16.025 µM 0.529695242301437 0.30626218746561 no 1049 0.29816162358297 1516 1840002
SGTC_1206 3978-0017 132 µM 0.529584833185361 0.306300319947816 no 1050 0.298199906160015 1501 3873677
SGTC_1176 0848-0131 83.3 µM 0.529273840477741 0.306407740145001 no 1051 0.298307749888013 1491 6769040
SGTC_3302 9125395 16.351 µM 0.526407393918497 0.307398623869028 no 1052 0.299302589738789 1486 17599668
SGTC_1948 st076329 66.6 µM 0.524563195745162 0.308036877601585 no 1053 0.299943438722473 1371 24208413
SGTC_2741 miltefosine 3.04 µM 0.524208336316681 0.308159756692034 no 1054 0.300066821678489 1415 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2285 7945142 200 µM 0.523313414775103 0.308469741484829 no 1055 0.300378083605449 1447 2970608
SGTC_2369 9071472 200 µM 0.522441364366515 0.308771935529468 no 1056 0.30068153100777 1500 17296037
SGTC_2931 9014674 55.67 µM 0.522221388274366 0.308848184919498 no 1057 0.30075809794084 1412 2996810
SGTC_2395 5646831 180.19 µM 0.521962393598802 0.308937969718746 no 1058 0.300848257321223 1508 6808628
SGTC_1563 conessine 56.1 µM 0.521644905383391 0.309048047849812 no 1059 0.300958795684563 1517 441082 An anti-amoebic, histamine inhibitor.
SGTC_2640 pentamidine 10.38 µM 0.518848052171301 0.310018500658179 no 1060 0.301933352910962 1500 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_957 1187-1561 14.1 µM 0.518158106611424 0.310258102142753 no 1061 0.302173980731424 1430 1538454
SGTC_3231 9132313 49.47 µM 0.517904420758862 0.310346221394994 no 1062 0.302262478732971 1486 4905967
SGTC_295 k015-0027 31 µM 0.514245328857686 0.311618437249316 no 1063 0.303540239853056 1450 3887424
SGTC_1692 fluoroquinolonic acid 71 µM 0.512631257954261 0.312180344229721 no 1064 0.30410464183096 1477 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1039 k821-0043 94 µM 0.51175026557312 0.312487228902386 no 1065 0.3044129009524 1552 15992768
SGTC_1096 rimcazole 32.2 µM 0.51131081250597 0.312640356518972 no 1066 0.304566717499418 1423 18528119 A dopamine reuptake inhibitor.
SGTC_3127 9126946 49.47 µM 0.511096647192218 0.312714994242612 no 1067 0.304641691774039 1408 27243249
SGTC_2982 9019404 25.97 µM 0.511017890312392 0.312742443355662 no 1068 0.304669264782431 1302 22333232
SGTC_1398 3558-0053 112 µM 0.509760871183004 0.313180692353401 no 1069 0.305109500887262 1436 4532369
SGTC_1650 st011916 45.8 µM 0.509708271956684 0.313199036383942 no 1070 0.305127928462755 1523 242528
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.509668211666693 0.313213007758546 no 1071 0.305141963487655 1534 688798
SGTC_1945 st075991 56.6 µM 0.508504654687214 0.313618925302685 no 1072 0.305549737806306 1407 1084980
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.506224068564661 0.314415183337508 no 1073 0.306349680240925 1458 16486 A toxic proline analog.
SGTC_2840 9008771 71.43 µM 0.506068657459057 0.314469476030596 no 1074 0.306404226181649 1565 2992978
SGTC_528 3492-0019 172 µM 0.504867812520274 0.314889125068701 no 1075 0.306825841384903 1494 2869262
SGTC_2943 9068529 45.32 µM 0.504457087640137 0.31503271249583 no 1076 0.306970105098085 1448 3270634
SGTC_200 k038-0079 37.545 µM 0.503118811582548 0.315500761179172 no 1077 0.307440370773809 1494 3436683
SGTC_1330 1469-0054 61.8 µM 0.502564252735063 0.315694799430757 no 1078 0.307635333731949 1581 7102664
SGTC_1875 nocodazole 6 µM 0.502368776063177 0.315763208167525 no 1079 0.307704069260012 1494 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_193 1273-0060 1.558 µM 0.497291082340654 0.31754239634859 no 1080 0.309491899715508 1418 2847393 YHR072W ERG7
SGTC_2659 sanguinarine 24.21 µM 0.494490547900226 0.318525493683603 no 1081 0.31047989005478 1471 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1315 1237-0019 3.69 µM 0.492305735334461 0.319293337126729 no 1082 0.311251613130016 1556 825140
SGTC_677 0929-0063 136 µM 0.492172759622745 0.31934009597223 no 1083 0.311298609869223 1455 1539583
SGTC_1880 MG-132 525 µM 0.490684503253681 0.319863614124728 no 1084 0.311824804328303 1558 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_796 1234-0020 70.7 µM 0.489164955339332 0.320398510023606 no 1085 0.31236245896689 1453 46495034
SGTC_959 1222-0044 107 µM 0.488067959274345 0.32078489561013 no 1086 0.312750852575523 1548 6083612
SGTC_3264 9137442 49.47 µM 0.487596133231246 0.320951142638985 no 1087 0.312917967504293 1575 17015726
SGTC_1888 azatryptophan 97.5 µM 0.486712369464314 0.321262631744981 no 1088 0.313231089101514 1479 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2348 9022543 33.42 µM 0.486160012636768 0.321457377898368 no 1089 0.313426860107083 1531 3162678 YDL140C RPO21
SGTC_69 0096-0274 206.684 µM 0.485769936824117 0.321594937709706 no 1090 0.313565145773942 1587 6741392
SGTC_2206 7254556 146.969 µM 0.485547430391229 0.32167341532058 no 1091 0.31364403820558 1540 4398905
SGTC_124 0136-0217 7.121 µM 0.485307164340956 0.321758165651557 no 1092 0.313729237102484 1598 3976905
SGTC_196 k015-0023 18.111 µM 0.48510541009152 0.321829338672941 no 1093 0.313800787299871 1494 5211998
SGTC_2863 9028737 58.44 µM 0.484820037296325 0.321930021044208 no 1094 0.31390200396529 1598 6460917
SGTC_775 4577-0580 57.3 µM 0.483166566697041 0.322513639106901 no 1095 0.314488736091989 1563 2006902
SGTC_2018 5133068 143 µM 0.478593391499823 0.324130087727968 no 1096 0.316113960291033 1491 785362
SGTC_51 1013-0126 23.419 µM 0.4778439335859 0.324395310965303 no 1097 0.316380644459315 1624 1627850
SGTC_3136 9095672 49.47 µM 0.477779084877692 0.324418264255463 no 1098 0.316403724461547 1513 17217380
SGTC_1182 1222-0449 220 µM 0.476917242933548 0.32472337772426 no 1099 0.31671052649656 1537 658318
SGTC_405 ebelactone b 50 µM 0.473720186603768 0.325856241479904 no 1100 0.317849728119521 1499 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3219 9131112 49.47 µM 0.473485053304455 0.325939623669396 no 1101 0.317933581040937 1493 17612988 YMR079W SEC14
SGTC_1401 3807-4679 7.6 µM 0.472951873083136 0.326128730514788 no 1102 0.318123757637098 1536 3291456
SGTC_475 α-linolenic acid 10 µM 0.47277355858923 0.326191984574025 no 1103 0.318187370182316 1583 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2953 9074162 66.49 µM 0.472181807404361 0.326401934150014 no 1104 0.318398512020327 1658 16451992
SGTC_347 4534-1311 26.2 µM 0.471834963920629 0.326525017599379 no 1105 0.31852229614613 1498 2862016
SGTC_2418 pentamidine 31.67 µM 0.471142684045739 0.326770741629084 no 1106 0.318769422784955 1453 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.470390541140891 0.327037799162258 no 1107 0.319038010403191 1568 5393153
SGTC_469 w7 172 µM 0.468794472022321 0.327604796355483 no 1108 0.319608275826508 1557 45115570 A P450 inhibitor.
SGTC_2046 4110841 106 µM 0.468654019005753 0.327654710791533 no 1109 0.319658479253351 1545 44119630 YMR134W ERG29
SGTC_2728 chlorpromazine 9.18 µM 0.467962769353084 0.32790041315678 no 1110 0.319905607180342 1546 2726 A thorazine and dopamine antagonist.
SGTC_1984 st072354 53.1 µM 0.467747914893231 0.327976797636204 no 1111 0.319982435861476 1534 5762938
SGTC_653 0203-0016 55.2 µM 0.467647691140461 0.328012431376565 no 1112 0.32001827698956 1566 295302
SGTC_2349 9023730 187.07 µM 0.466356006232122 0.32847181945302 no 1113 0.320480348112367 1614 4126287
SGTC_563 tetrahydrosecaminediol 614 µM 0.462500110957828 0.329844710498597 no 1114 0.321861361387861 1633 334274 A psychoactive constituent of the cannabis plant.
SGTC_1636 st007707 68.9 µM 0.461933798348107 0.330046539790992 no 1115 0.322064397821589 1628 403051
SGTC_3203 9113543 49.47 µM 0.460906296667516 0.330412859473477 no 1116 0.322432917010769 1590 17018012
SGTC_247 mechlorethamine 29.705 µM 0.459732562159135 0.330831512249279 no 1117 0.322854096997836 1549 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_95 0471-0001 561.058 µM 0.458913210104847 0.331123887828876 no 1118 0.323148246026189 1458 4015405
SGTC_3086 9117350 49.47 µM 0.45878676017573 0.331169019090509 no 1119 0.323193651661557 1479 2679265
SGTC_647 0140-0236 81 µM 0.456066406665328 0.332140533868454 no 1120 0.32417111306026 1586 990837
SGTC_2920 7982904 15.77 µM 0.455972512421016 0.332174086343259 no 1121 0.324204872284175 1499 6456808
SGTC_2597 laccaic acid a 100 µM 0.453857020349728 0.33293039935669 no 1122 0.324965869971464 1555 5491415 A textile dye.
SGTC_1609 st001574 46.4 µM 0.45254658846746 0.333399235382525 no 1123 0.325437633336762 1526 3960012
SGTC_1961 st076550 68.7 µM 0.451090010081055 0.333920664113226 no 1124 0.325962338705129 1555 1579337
SGTC_1521 st012942 49.4 µM 0.448806098118661 0.334738908945797 no 1125 0.326785769651631 1742 24207259
SGTC_939 1165-0479 45.3 µM 0.445030797772277 0.33609318614626 no 1126 0.32814874883982 1561 1377347
SGTC_1510 1123-0200 71.5 µM 0.444782784559425 0.336182228300812 no 1127 0.328238368297741 1675 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.444707954590656 0.336209095697501 no 1128 0.328265410013491 1588 688788
SGTC_648 0375-0473 33.3 µM 0.444575024254068 0.336256825858701 no 1129 0.328313449996575 1587 1713139
SGTC_895 0964-0006 13.7 µM 0.443411970393985 0.336674546183755 no 1130 0.328733889571737 1557 6738897
SGTC_1054 3429-0080 167 µM 0.442418994132339 0.337031341306467 no 1131 0.329093018382907 1638 1162877
SGTC_2117 5521686 200 µM 0.442260487467552 0.337088309327398 no 1132 0.329150359955416 1513 803312
SGTC_356 1634-0012 32.5 µM 0.438867394539816 0.338308696667654 no 1133 0.330378811734863 1654 735457
SGTC_3237 9133362 49.47 µM 0.436952155067337 0.338998298975426 no 1134 0.331073023327477 1623 43845137
SGTC_1133 3473-0247 50 µM 0.434079939593525 0.340033481977995 no 1135 0.33211519611088 1504 711311
SGTC_1805 st050013 60.3 µM 0.433554685196362 0.340222921137512 no 1136 0.332305923559514 1612 4037144
SGTC_798 1287-0182 476 µM 0.433393332911535 0.340281122832293 no 1137 0.332364521625169 1705 1649755
SGTC_37 0566-0070 1.56 µM 0.432946322723049 0.340442384611665 no 1138 0.332526883038613 1676 1626686
SGTC_510 ag-490 170 µM 0.432489569865083 0.340607191260918 no 1139 0.332692815608714 1675 5328779
SGTC_1453 4237-0541 195 µM 0.430012959309682 0.341501336992028 no 1140 0.333593107131408 1702 739892
SGTC_966 1300-0360 30.2 µM 0.429853067134856 0.341559094480733 no 1141 0.333651263764942 1585 70588
SGTC_1172 0370-0043 85 µM 0.429686832523012 0.341619146967545 no 1142 0.333711731533737 1626 376585
SGTC_2601 securinine 100 µM 0.429120290005548 0.341823841353727 no 1143 0.333917843568128 1542 442872 A GABA receptor antagonist.
SGTC_1202 1988-0068 29.6 µM 0.429070282370656 0.341841911574253 no 1144 0.333936039094789 1521 2850480
SGTC_3149 9097855 49.47 µM 0.42606864894282 0.342927211827569 no 1145 0.335028912033582 1726 25236625 YMR079W SEC14
SGTC_1493 4348-0038 111 µM 0.425323551105945 0.343196818105023 no 1146 0.335300413732666 1644 800424
SGTC_862 0452-0056 10.2 µM 0.424749946786976 0.343404425543966 no 1147 0.335509484575493 1573 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1103 duloxetine 36.1 µM 0.424148426785308 0.343622187407403 no 1148 0.335728785020842 1692 60835 A selective serotonin reuptake inhibitor.
SGTC_1502 4534-4282 27.7 µM 0.423916229695945 0.34370626112963 no 1149 0.335813453746038 1597 3278949
SGTC_2371 9071574 200 µM 0.423627495289936 0.343810816618057 no 1150 0.335918749955759 1593 45596039
SGTC_1779 st039427 55 µM 0.419372282853199 0.345353080858996 no 1151 0.337472038702581 1753 1124498
SGTC_1757 st041620 31.8375 µM 0.418285287140187 0.345747466218274 no 1152 0.337869272728865 1576 5289815
SGTC_540 1187-0821 17.3 µM 0.417687652127998 0.345964372389044 no 1153 0.338087750730449 1564 847520
SGTC_2871 9038510 12.99 µM 0.417328573481745 0.346094721022981 no 1154 0.33821904568912 1739 4945164
SGTC_1728 st035614 33.7865 µM 0.416604240441602 0.346357715625569 no 1155 0.338483953595709 1634 15945546
SGTC_2367 9070478 135.38 µM 0.416232430750879 0.346492743006022 no 1156 0.338619965373885 1598 572802
SGTC_1019 4262-0212 3.4 µM 0.415396412903553 0.346796424661193 no 1157 0.338925866088525 1624 4677213
SGTC_2879 9041815 71.43 µM 0.414670224037946 0.347060291091129 no 1158 0.339191666381188 1580 4942971
SGTC_59 0330-0160 1.33 µM 0.414556526517609 0.347101610697145 no 1159 0.339233289299335 1657 4293482
SGTC_1722 st034304 3.6505 µM 0.414436050088289 0.347145395857209 no 1160 0.339277396012916 1559 4036148 YLR033W RSC58
SGTC_2406 ethylparaben 405.7 µM 0.414377521154536 0.347166667963933 no 1161 0.339298824392682 1421 8434 A possible steroid mimic.
SGTC_1210 3013-0140 750 nM 0.413638484734068 0.347435309200703 no 1162 0.339569442150614 1737 905973
SGTC_770 0389-1121 67.2 µM 0.413179987431804 0.347602012437154 no 1163 0.339737374676844 1723 6753108
SGTC_2321 7390090 138.78 µM 0.412693451999961 0.347778942180556 no 1164 0.339915611444259 1528 649046
SGTC_578 3460-0051 92 µM 0.41263402598373 0.347800554862682 no 1165 0.339937383948494 1698 2876744
SGTC_3356 9151811 4.48 µM 0.411795068512516 0.348105728537793 no 1166 0.34024481813641 1581 1859254 YPR165W RHO1
SGTC_1938 st074717 56.4 µM 0.411767227847841 0.34811585736343 no 1167 0.340255022111099 1551 17250979
SGTC_3135 9127742 49.47 µM 0.411755055404224 0.348120285903775 no 1168 0.340259483510683 1598 3643468
SGTC_3055 9094636 49.47 µM 0.411747318654457 0.348123100674631 no 1169 0.340262319167578 1663 25236176
SGTC_2952 9073731 13.78 µM 0.411671824742701 0.348150567177551 no 1170 0.340289989507952 1545 16457353
SGTC_721 1187-1332 279 µM 0.410812998199697 0.348463084995855 no 1171 0.340604830666597 1563 25730
SGTC_1287 0971-0001 34.6 µM 0.410367393931509 0.348625276192142 no 1172 0.340768230566927 1639 4665869
SGTC_3080 9117754 49.47 µM 0.409834281399697 0.348819355033916 no 1173 0.340963758380731 1730 9550191
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.408179127652237 0.349422163251701 no 1174 0.341571085350873 1557 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_333 3486-0131 40.1 µM 0.405709434606454 0.350322333422677 no 1175 0.342478054630932 1733 6744690
SGTC_2127 5253358 187.912 µM 0.405348475534443 0.350453968784517 no 1176 0.342610689389388 1571 20612
SGTC_2023 5144124 124 µM 0.404818663544929 0.350647214334024 no 1177 0.342805404460205 1595 2830192
SGTC_3042 9091578 49.47 µM 0.404198574955045 0.35087343679003 no 1178 0.343033350787949 1631 25236497
SGTC_968 1309-0633 340 µM 0.400937204915943 0.352064127671159 no 1179 0.344233178540458 1711 3761976
SGTC_553 k007-0256 45.7 µM 0.400821249640123 0.352106488483027 no 1180 0.344275866374064 1646 6287000
SGTC_2060 5238662 140 µM 0.399757096880124 0.352495330696903 no 1181 0.344667716700703 1616 790130
SGTC_1258 0671-0043 57.1 µM 0.399213843306173 0.352693895437794 no 1182 0.344867821921863 1579 4298767
SGTC_3174 9107204 49.47 µM 0.397802442970812 0.353209964195604 no 1183 0.345387908171795 1677 3938802
SGTC_3 0833-0587 95.581 µM 0.397592275606087 0.353286833560825 no 1184 0.345465377652283 1627 5382644
SGTC_514 4466-0038 2.65 nM 0.39643195171563 0.353711333295379 no 1185 0.345893199374265 1672 5722064
SGTC_1307 1187-1599 12.2 µM 0.39637691819078 0.35373147160866 no 1186 0.345913495616776 1622 1538471
SGTC_857 0438-0306 1.35 µM 0.394725215084088 0.354336066454758 no 1187 0.346522845892757 1637 4686136
SGTC_298 1391-0729 10 µM 0.394561393306903 0.354396052363331 no 1188 0.346583305101955 1629 3237558
SGTC_2873 9040596 71.43 µM 0.393231837929472 0.354883023383291 no 1189 0.347074128308742 1590 6463863
SGTC_1402 3909-7673 35.9 µM 0.392481625363664 0.355157905520477 no 1190 0.347351192669531 1605 5328014
SGTC_1329 1447-1697 50.6 µM 0.391783094113387 0.35541391911592 no 1191 0.347609243729612 1648 2840515
SGTC_1792 st045773 43.6 µM 0.391699549267721 0.355444542899556 no 1192 0.347640111555144 1642 2919270
SGTC_1726 st035556 14.5795 µM 0.391535267961702 0.355504763760959 no 1193 0.347700812520854 1737 5919439
SGTC_2245 6637752 200 µM 0.391290783759499 0.355594391405248 no 1194 0.347791155208528 1775 681890
SGTC_2585 alliin 100 µM 0.390294342644624 0.355959768188615 no 1195 0.34815945308732 1742 87310 A garlic compound which reacts with lipids.
SGTC_2524 avocatin b 10.57 µM 0.390290958554099 0.355961009298553 no 1196 0.348160704136423 1726 6710748
SGTC_413 propylparaben 100 µM 0.389323148935084 0.3563160145655 no 1197 0.348518557054094 1602 7175 A pharmaceutical preservative.
SGTC_133 0724-0033 378.92 µM 0.388462042066052 0.356631984595068 no 1198 0.34883706943088 1606 280309
SGTC_2064 5220758 200 µM 0.388005641839235 0.356799493613164 no 1199 0.349005929236206 1666 788518
SGTC_2335 9018011 154.17 µM 0.386636397866124 0.357302202155102 no 1200 0.349512703992009 1749 6458208
SGTC_1001 4048-4355 44.4 µM 0.384345355875452 0.358143896279337 no 1201 0.350361247774603 1609 21824233
SGTC_332 4112-0506 40.9 µM 0.384267862672744 0.358172378193261 no 1202 0.35038996238043 1671 2790355
SGTC_1137 ixabepilone 100 µM 0.383270662302378 0.35853896039439 no 1203 0.350759544784687 1590 154225 A novel microtubule stabilizer.
SGTC_1041 0206-0046 107 µM 0.38207177322963 0.358979858246608 no 1204 0.351204064060644 1653 50494
SGTC_371 0195-0006 7.36 µM 0.381967568876052 0.359018188838587 no 1205 0.351242710160525 1572 3928593
SGTC_144 4161-2749 112.381 µM 0.381509020776647 0.359186878308283 no 1206 0.35141278942477 1636 797501 YMR168C CEP3
SGTC_728 3030-5151 22.5 µM 0.37964902086654 0.359871411435633 no 1207 0.352102983527514 1685 3125388
SGTC_2697 mebhydrolin 72.4 µM 0.377294103996101 0.360738733079398 no 1208 0.352977526658247 1800 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3126 9127922 49.47 µM 0.377286709633235 0.36074145757248 no 1209 0.352980273921887 1685 45595682
SGTC_2178 5812956 200 µM 0.376991514548027 0.360850229573778 no 1210 0.353089955448321 1676 5403383
SGTC_1689 st020265 53.493 µM 0.376276340455215 0.361113799983406 no 1211 0.353355733319813 1757 5758320 YPR016C TIF6
SGTC_1885 st057546 99.9 µM 0.3758438085867 0.361273237383052 no 1212 0.353516508481608 1750 702008
SGTC_139 0099-0334 718.624 µM 0.375599058286672 0.361363466503596 no 1213 0.35360749548479 1709 97690
SGTC_977 1348-1378 135 µM 0.375294350781264 0.361475810095463 no 1214 0.353720783532189 1628 X977
SGTC_2519 cryptotanshinone 88.04 µM 0.375010270990385 0.361580559147773 no 1215 0.353826414014538 1735 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3226 9131256 49.47 µM 0.374864058918019 0.36163447612975 no 1216 0.35388078499942 1631 17178073
SGTC_910 3454-3003 490 µM 0.369957606234523 0.363445360304957 no 1217 0.355707039049396 1736 820824
SGTC_2570 licareol 100 µM 0.367248235627289 0.364446653037821 no 1218 0.356716931161548 1640 443158
SGTC_155 k072-0202 43.6 µM 0.365876771384757 0.364953853665262 no 1219 0.357228515063286 1749 5857737
SGTC_2078 5212016 200 µM 0.365727176381856 0.365009191827748 no 1220 0.357284332571411 1775 1899708
SGTC_1786 berberine 21.6 µM 0.365633708576033 0.365043768852633 no 1221 0.357319209217116 1617 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.365245266482561 0.365187478982977 no 1222 0.357464165552092 1667 3256 An antibiotic and ribosome inhibitor.
SGTC_1633 st005664 67.9 µM 0.364758848413453 0.365367463532054 no 1223 0.35764571293562 1633 2063822
SGTC_2626 ethyl orsellinate 100 µM 0.364654279761222 0.365406159927853 no 1224 0.357684745638975 1647 75653 A natural product.
SGTC_1771 st048882 4.1505 µM 0.364452086842923 0.365480986784124 no 1225 0.357760223111631 1608 4580403
SGTC_2965 9082772 38.63 µM 0.364284647675676 0.365542955968037 no 1226 0.357822731415944 1842 16459634
SGTC_1947 st076332 61.6 µM 0.363218547366052 0.365937601614774 no 1227 0.358220816799068 1776 24208416
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.362158820754464 0.366330028496492 no 1228 0.358616675022546 1644 61125 An anti-inflammatory.
SGTC_2891 9063876 19.48 µM 0.361979117259919 0.366396588292974 no 1229 0.358683817892512 1814 6472478
SGTC_891 0929-0073 133 µM 0.361586760892038 0.366541925864534 no 1230 0.358830429731351 1757 5603632
SGTC_1081 sertraline 6 µM 0.358839267449648 0.367560194082593 no 1231 0.359857667586292 1787 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1766 st045414 44.774 µM 0.358826665316099 0.367564866801737 no 1232 0.359862381634574 1683 253960
SGTC_2986 9022445 71.43 µM 0.355461401531568 0.368813365692788 no 1233 0.361121978189864 1821 6459286
SGTC_2239 6685329 187.64 µM 0.352762649627637 0.36981559344039 no 1234 0.362133193562216 1688 805680
SGTC_2586 curcumin 80 µM 0.350908692231669 0.370504605505908 no 1235 0.362828425100004 1790 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2608 thymoquinone 42.66 µM 0.350659023055402 0.370597425347896 no 1236 0.362922085320103 1697 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_998 3996-0085 177 µM 0.35002011897755 0.370834985858613 no 1237 0.363161799398846 1820 715391
SGTC_3057 9095946 49.47 µM 0.348060129191628 0.371564065968717 no 1238 0.363897513330288 1717 24540043
SGTC_1893 st059353 36.1 µM 0.34768893525153 0.371702195277436 no 1239 0.364036903613603 1666 3112488
SGTC_2403 6032726 181.2 µM 0.346917546828924 0.371989298441184 no 1240 0.364326631949669 1682 2881040
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.345074374823343 0.37267559689441 no 1241 0.365019228756934 1605 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2782 7736369 71.43 µM 0.344124449839255 0.373029456099082 no 1242 0.365376348119039 1675 2950836 YOL077C BRX1
SGTC_3167 9103034 49.47 µM 0.342750467802419 0.373541471479412 no 1243 0.3658930960282 1729 5127859
SGTC_1323 1348-1351 11.2 µM 0.340310059247535 0.374451441524283 no 1244 0.366811521290398 1695 6989654
SGTC_1723 st034307 2.5525 µM 0.340129191576151 0.374518910671186 no 1245 0.366879619603053 1676 867466
SGTC_407 eburnamonine 100 µM 0.338038782631806 0.375298975167086 no 1246 0.367666980978061 1677 3195
SGTC_2971 9092186 9.93 µM 0.335551373045444 0.376227850430325 no 1247 0.368604599241157 1598 25236400
SGTC_2195 6536160 144.242 µM 0.335512390518149 0.376242413428619 no 1248 0.368619299780345 1683 3834386
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.333840996283364 0.376866974324366 no 1249 0.369249772916387 1747 6708630 An antioxidant.
SGTC_1045 1348-1485 165 µM 0.333345027980413 0.377052368162727 no 1250 0.369436926826704 1719 6810614
SGTC_3068 9116768 49.47 µM 0.332356131943841 0.377422103838922 no 1251 0.369810179606011 1718 41904888
SGTC_1627 st003713 25.6 µM 0.331483113126006 0.377748607903453 no 1252 0.370139797218184 1703 16195070 YER133W GLC7
SGTC_2748 diazoxide 86.69 µM 0.330818889192902 0.377997082406589 no 1253 0.370390646001059 1784 3019 A potassium channel activatior.
SGTC_3097 9117246 49.47 µM 0.329754135247615 0.378395493425885 no 1254 0.370792872696544 1705 16423892
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.329157720812395 0.378618717087744 no 1255 0.371018238896797 1787 279621
SGTC_1963 st076565 50.3 µM 0.328465886370031 0.378877704916246 no 1256 0.371279716734635 1704 4914280
SGTC_842 0271-0008 11.1 µM 0.327999257876065 0.379052417749724 no 1257 0.371456111871243 1797 1221709
SGTC_2670 beta-carotene 100 µM 0.327266588191693 0.37932679031635 no 1258 0.371733130497238 1780 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2887 9044784 58.44 µM 0.326866872186552 0.379476502926729 no 1259 0.371884289071379 1762 6465546
SGTC_2373 9071805 200 µM 0.326685745556651 0.379544349395739 no 1260 0.371952791314218 1901 10149009
SGTC_1447 4239-0816 81.9 µM 0.326485062912042 0.379619525494169 no 1261 0.372028694391687 1671 1341554
SGTC_784 4579-0127 173 µM 0.324751876869596 0.38026896934787 no 1262 0.372684434344996 1877 1948547
SGTC_505 gw-5074 63.9 µM 0.32433345052938 0.380425808967027 no 1263 0.372842798689369 1819 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2495 cafestol 54.53 µM 0.322630867075072 0.381064194368142 no 1264 0.37348740712804 1795 16667697 An anti-infammatory.
SGTC_1026 k007-1105 30.6 µM 0.321804980985346 0.381373977952779 no 1265 0.373800220295784 1735 7066794
SGTC_1427 4048-4900 550 nM 0.32109323897423 0.381641007955546 no 1266 0.374069866888169 1858 24132586
SGTC_2263 7948595 193.29 µM 0.320450835008994 0.381882072220754 no 1267 0.374313297377415 1727 2971371
SGTC_933 2914-0560 114 µM 0.320296586546898 0.381939961302486 no 1268 0.37437175525778 1901 463887
SGTC_2740 felodipine 17.08 µM 0.318631383256017 0.382565075973809 no 1269 0.375003026250488 1876 3333 L-type calcium channel blocker
SGTC_1432 4049-0298 68.4 µM 0.318070298372002 0.38277577537819 no 1270 0.375215806518692 1874 741646
SGTC_1615 st002656 86.5 µM 0.315095018302009 0.383893635264729 no 1271 0.376344755416466 1729 1584458
SGTC_2557 derrustone 83.84 µM 0.313459825063055 0.384508415583874 no 1272 0.376965669352374 1698 629853 An antioxidant.
SGTC_2041 5107442 45.335 µM 0.313231774523545 0.384594178411413 no 1273 0.377052289803045 1851 793005
SGTC_3003 9075612 71.4286 µM 0.312494711374646 0.384871403910495 no 1274 0.37733229084214 1769 6501993
SGTC_833 3852-0053 558 µM 0.312441205032969 0.384891531104168 no 1275 0.37735261974251 1820 3123681
SGTC_711 k292-0785 179 µM 0.312310097267778 0.384940850520379 no 1276 0.377402433530476 1722 4146315
SGTC_1338 1486-1223 76 µM 0.309888285411431 0.385852208733243 no 1277 0.378322955744204 1835 3444526
SGTC_1511 0906-3109 28.5 µM 0.309047619539749 0.386168709508358 no 1278 0.378642651735029 1752 2882180
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.307822228912687 0.386630190274929 no 1279 0.379108803058701 1794 97141
SGTC_397 arbidol 50 µM 0.307148103639595 0.386884133534759 no 1280 0.379365322343112 1863 131410 A RNA synthesis inhibitor.
SGTC_2760 etidronate 98.04 µM 0.30520825939881 0.387615143490216 no 1281 0.380103771125402 1739 3305 A chelator and antioxidant.
SGTC_176 1486-1328 72.834 µM 0.304834182252801 0.387756156459761 no 1282 0.380246223045196 1713 22310231
SGTC_2048 5246248 200 µM 0.30401003571685 0.388066880823446 no 1283 0.380560122704941 1886 677046
SGTC_2033 5192550 145 µM 0.303173586296556 0.38838231697709 no 1284 0.380878788694383 1743 182073
SGTC_1068 loratadine 26.9 µM 0.30149844377831 0.38901425660541 no 1285 0.381517218257833 1749 3957 A H1 histamine antagonist.
SGTC_2964 9083345 53.42 µM 0.299435057369287 0.389793063006322 no 1286 0.382304058294975 1719 17741579
SGTC_812 4251-0442 148 µM 0.29834992481539 0.39020281422957 no 1287 0.382718051884515 1898 5723007
SGTC_2702 st077768 96.8 µM 0.297838112036115 0.390396119547106 no 1288 0.382913362331342 1737 6484119
SGTC_68 0986-0284 82.829 µM 0.294863067419055 0.391520292003898 no 1289 0.384049243069301 1651 423278 YIL048W NEO1
SGTC_2987 9018338 71.43 µM 0.294610885095595 0.391615625301421 no 1290 0.384145572978435 1778 5055682
SGTC_2284 7945075 39.21 µM 0.292924943415506 0.392253134241551 no 1291 0.384789761302565 1937 1245402
SGTC_1107 amlodipine 47 µM 0.29223362070352 0.392514629395573 no 1292 0.385054003703406 1791 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1088 bifonazole 369 nM 0.290536088921898 0.393156932208516 no 1293 0.38570307292637 1807 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_289 k017-0060 526 µM 0.28966179753932 0.393487855439964 no 1294 0.386037492512001 1791 5512909
SGTC_1434 4073-0095 163 µM 0.288667595399136 0.393864258935429 no 1295 0.386417881303249 1875 24133745
SGTC_2447 5741742 33.78 µM 0.287919285745154 0.39414763332814 no 1296 0.38670426192167 1854 1776504
SGTC_1960 st011366 51.8 µM 0.287210104113396 0.394416242214891 no 1297 0.386975725069467 1787 3972846
SGTC_1043 0916-0009 19.3 µM 0.287037575788981 0.394481596459915 no 1298 0.387041774462302 1974 3101130
SGTC_1829 berberine 14.4 µM 0.286819448903998 0.394564227827294 no 1299 0.387125285132797 1916 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2087 5276107 200 µM 0.285939157653072 0.394897750112408 no 1300 0.387462360890084 1774 144405
SGTC_2271 7849410 118.62 µM 0.28552111192298 0.395056165101415 no 1301 0.387622466143662 1962 972430
SGTC_2993 9054257 71.4286 µM 0.284289042321144 0.39552314855374 no 1302 0.388094441415807 1790 6470217 YGL055W OLE1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.284048022111731 0.395614518468428 no 1303 0.388186789630425 1777 688803
SGTC_1025 k007-0731 70 µM 0.282242152437957 0.396299299530329 no 1304 0.388878919312595 1762 6256118
SGTC_3014 9081533 49.47 µM 0.282112537360579 0.396348461564298 no 1305 0.388928610050422 1922 21367265
SGTC_890 0929-0006 47.2 µM 0.280133359501126 0.397099353283119 no 1306 0.38968759585572 1759 1378169
SGTC_1101 ebselen 5.29 µM 0.280003923878171 0.397148473935985 no 1307 0.389737247220673 1951 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1863 st057641 20.1 µM 0.279516122329576 0.397333608652342 no 1308 0.389924383530866 1969 3921635
SGTC_2477 5967686 25.23 µM 0.276981085635074 0.398296099571935 no 1309 0.390897314825708 1769 776118
SGTC_1265 0819-1001 68.8 µM 0.275272892344698 0.398945007956744 no 1310 0.391553294518971 1824 3106768
SGTC_2857 9024691 58.44 µM 0.274634222166791 0.399187697810832 no 1311 0.391798635717649 1811 16478292
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.271742338313178 0.400287078289801 no 1312 0.392910072268274 1901 688751
SGTC_120 rhodamine 6G 52.259 µM 0.271374060568577 0.400427139931765 no 1313 0.39305167520604 1813 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2817 7995342 71.43 µM 0.270948963227032 0.400588826853374 no 1314 0.393215142896457 1749 18879975
SGTC_224 benfluorex 43.875 µM 0.270323686816409 0.400826683373967 no 1315 0.393455622012562 1925 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2664 lyso-paf C-16 73.48 µM 0.270176878281586 0.400882534996809 no 1316 0.39351208995643 1850 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1354 1498-1681 81 µM 0.2700037919611 0.400948386304126 no 1317 0.393578668176859 1837 5754243
SGTC_1124 fisetin 1.16336 µM 0.269620111911571 0.401094368777563 no 1318 0.39372626305599 1789 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1867 st057372 64 µM 0.269257514335017 0.401232342490785 no 1319 0.393865761917427 1870 688837
SGTC_1495 4469-0029 237 µM 0.269210280133873 0.40125031670648 no 1320 0.393883934904262 1805 793680
SGTC_2187 6125751 200 µM 0.268270991885089 0.401607791096351 no 1321 0.39424536659903 1857 874498
SGTC_1151 3909-8316 15.3 µM 0.26668089439585 0.402213138079239 no 1322 0.394857432700871 1835 800431
SGTC_3109 9122853 49.47 µM 0.266283861303896 0.402364324455463 no 1323 0.395010300679498 1894 1234709
SGTC_162 k030-0015 37.8 µM 0.2658024035522 0.402547678521741 no 1324 0.395195696010225 1959 1809920 YMR134W ERG29
SGTC_1112 tnp00069 1.16933 µM 0.264906455531693 0.402888940397993 no 1325 0.395540762577668 1938 145826
SGTC_2402 5553605 200 µM 0.264297265183327 0.403121020065166 no 1326 0.395775433724267 1893 6758546
SGTC_1516 st013856 110 µM 0.260442997755622 0.404590145538096 no 1327 0.397261039776114 1870 5281404 A mutagen and neurotoxin.
SGTC_2707 st078556 66.6 µM 0.260166142740626 0.404695726023931 no 1328 0.397367809690546 1992 17250899
SGTC_2912 7964298 10.93 µM 0.259745993077586 0.404855966122697 no 1329 0.397529856277826 1803 2975850
SGTC_1833 st055984 71 µM 0.259529957948376 0.404938365571946 no 1330 0.397613185271798 1830 676288
SGTC_201 4262-0159 12.803 µM 0.258232570803879 0.405433299495716 no 1331 0.398113711138381 1964 1341029
SGTC_1952 st077036 64.1 µM 0.25720477270781 0.405825496615349 no 1332 0.398510349917784 1974 2937007
SGTC_454 lyso-paf C-16 6.67 µM 0.257141588178882 0.405849610266589 no 1333 0.398534736959646 1758 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_666 0272-0154 136 µM 0.256608980529729 0.406052888059623 no 1334 0.398740320820989 1879 6870312
SGTC_1769 st044406 64.4 µM 0.25622006286604 0.40620134039338 no 1335 0.3988904588279 1830 670903
SGTC_1618 st003135 44.5 µM 0.256197527962797 0.406209942522117 no 1336 0.398899158674174 1946 1270615
SGTC_189 3970-0742 2.116 µM 0.256172412503027 0.406219529766316 no 1337 0.398908854831751 1965 2891807
SGTC_2354 9060492 162 µM 0.25577272014433 0.406372110617331 no 1338 0.399063169779791 1942 6471895
SGTC_2663 amphotericin b 100 µM 0.25555299815985 0.406455994604616 no 1339 0.399148007711989 1866 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_244 nsc-207895 1.295 µM 0.25499637063737 0.406668519337 no 1340 0.399362951204457 1823 42640
SGTC_1623 st003709 20.3 µM 0.254982263603014 0.406673905870281 no 1341 0.399368399077441 1792 16192618
SGTC_654 1124-0271 80.9 µM 0.254180428279059 0.406980102167956 no 1342 0.399678085072804 1787 5403748
SGTC_681 1642-0006 26.6 µM 0.253276494711228 0.4073253548303 no 1343 0.400027279281604 1907 4446530
SGTC_799 1310-0557 151 µM 0.252851227789926 0.407487808214175 no 1344 0.400191589763895 1870 5354492
SGTC_1363 1636-0063 10.4 µM 0.251614218609825 0.407960440211003 no 1345 0.400669633643873 1853 6072185
SGTC_396 dithiazanine 1.25 µM 0.251206826222218 0.408116124580004 no 1346 0.400827103594948 1820 10578 An antihelmenthic.
SGTC_789 1309-1135 70.6 µM 0.250636501853996 0.408334097517131 no 1347 0.401047578941008 1777 3092424
SGTC_223 busulfan 5 mM 0.249321144641591 0.408836923472227 no 1348 0.401556188295429 1939 2478 A DNA alkylator.
SGTC_2820 7989630 71.43 µM 0.249295547799899 0.408846709952954 no 1349 0.40156608748719 2005 2984098
SGTC_2805 7950783 58.44 µM 0.248915659984879 0.408991959735788 no 1350 0.401713010781873 1880 1178958 YDL195W SEC31
SGTC_583 1488-1091 88.9 µM 0.248779520126837 0.409044015737726 no 1351 0.401765666857572 2023 4303273
SGTC_1752 st044819 83.042 µM 0.248408945648791 0.409185720981324 no 1352 0.40190900641744 1818 441209 YML126C ERG13
SGTC_1803 st050068 52.4 µM 0.247720253063573 0.409449104008073 no 1353 0.402175430256779 1907 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3330 9141424 71.43 µM 0.24626816314197 0.410004573903518 no 1354 0.402737326626752 1962 27261020
SGTC_284 0988-0104 32.6 µM 0.245844096562711 0.410166826787888 no 1355 0.402901460126526 1948 4666532
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.245691127606719 0.410225358294078 no 1356 0.402960670431964 1822 803109
SGTC_1703 st026983 48.3 µM 0.244461394093758 0.410695971782467 no 1357 0.403436749042851 1994 1104023
SGTC_2203 7227154 166.4 µM 0.2426316628088 0.411396439549511 no 1358 0.404145375320787 1927 896304
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.2406484804084 0.4121559713316 no 1359 0.404913786098309 1943 616764
SGTC_1741 st038134 10.228 µM 0.239564312377383 0.412571332227189 no 1360 0.405334016888158 1962 1272587
SGTC_1619 st003326 88.7 µM 0.238815869301342 0.412858129063589 no 1361 0.405624182154694 1972 2849032
SGTC_1527 coumarin 137 µM 0.23864718100491 0.412922775371955 no 1362 0.405689588397342 1949 323 A hepatotoxic, DNA x-linker.
SGTC_3355 9151058 44.0485 µM 0.238459929729309 0.412994538324564 no 1363 0.405762195227789 1981 17015728
SGTC_1706 st031321 9.9705 µM 0.238430726010051 0.413005730740757 no 1364 0.405773519285375 1977 6103185
SGTC_3082 9117008 49.47 µM 0.237930239312438 0.413197554806421 no 1365 0.40596760065574 1868 41448529
SGTC_1810 st050138 53 µM 0.237362199256032 0.413415295495933 no 1366 0.406187906224027 2005 3444541
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.236468882271921 0.413757774942273 no 1367 0.40653442549459 1946 16623 A steroid.
SGTC_1865 st057639 52.2 µM 0.236124197282369 0.413889937668103 no 1368 0.406668149011389 1972 688818
SGTC_1229 0139-0193 12.2 µM 0.23588487497914 0.413981706868222 no 1369 0.406761002567495 2015 3090752
SGTC_2066 5222451 176 µM 0.235050881555427 0.414301542025817 no 1370 0.407084620757718 1919 2281147
SGTC_2301 7769476 200 µM 0.233445833972028 0.414917235008226 no 1371 0.407707612896817 1910 977820
SGTC_697 0508-1955 564 µM 0.232573691736271 0.415251874746106 no 1372 0.408046229054293 2023 6243113
SGTC_727 3032-0951 202 µM 0.232073585810164 0.415443792434167 no 1373 0.408240430159821 1908 3652836
SGTC_326 k292-0812 17.5 µM 0.230314469397626 0.416119020519492 no 1374 0.408923708928245 1999 3579357
SGTC_263 alizarin 107.927 µM 0.23004637458413 0.416221949177904 no 1375 0.409027867102524 1922 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1249 0481-0015 10.2 µM 0.229770199091905 0.416327986229867 no 1376 0.4091351714385 1862 4227577
SGTC_5 0352-0601 109.883 µM 0.229010369406459 0.416619752788051 no 1377 0.409430428332001 1921 762456
SGTC_947 3447-0010 211 µM 0.228870771824205 0.416673361782556 no 1378 0.409484679170293 1948 748350
SGTC_19 0279-0214 38.434 µM 0.227895796761326 0.417047819966856 no 1379 0.409863625225769 1925 3566274 YBR002C RER2
SGTC_903 1134-0042 114 µM 0.226448423063034 0.417603850761917 no 1380 0.410426334861744 1885 701009
SGTC_1734 st037168 69.4 µM 0.226423748594119 0.417613331269093 no 1381 0.410435929398784 1836 708907
SGTC_3345 9148410 3.559 µM 0.226232384456795 0.417686859465006 no 1382 0.410510342153363 1999 4903596
SGTC_739 1486-1183 203 µM 0.226029371258163 0.41776486674717 no 1383 0.410589288216409 2032 4346692
SGTC_1061 3448-9325 110 µM 0.225552371197319 0.41794816548155 no 1384 0.410774794233278 2039 723482
SGTC_342 k048-0088 23.3 µM 0.225513311430051 0.417963175925745 no 1385 0.410789985518194 1856 6820570
SGTC_889 0919-1524 82.7 µM 0.224929504755128 0.418187543707438 no 1386 0.411017057939664 1878 3905452
SGTC_3030 9087619 49.47 µM 0.222744494196 0.419027519713073 no 1387 0.411867184911313 1882 25236973
SGTC_497 capsazepine 133 µM 0.221254630050953 0.419600474957071 no 1388 0.412447087241445 1813 2733484 A calcium channel blocker.
SGTC_2407 paclitaxel 400 µM 0.220692563760795 0.419816672464957 no 1389 0.412665910985906 1951 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2088 5278280 127.392 µM 0.220630025623119 0.419840729113436 no 1390 0.412690260023786 1936 791502
SGTC_3318 9139014 38.6185 µM 0.215957842478077 0.421638826545535 no 1391 0.414510304476003 1900 16643984
SGTC_3065 9113888 49.47 µM 0.213370959016045 0.422635098672131 no 1392 0.415518815140525 1994 16648368
SGTC_482 fipronil 114 µM 0.212357895285783 0.423025389565913 no 1393 0.415913915658522 2035 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_614 0462-0418 107 µM 0.212100063522532 0.423124733389455 no 1394 0.416014485073573 1976 5188303
SGTC_2148 5546263 113.568 µM 0.211588629309845 0.423321805920328 no 1395 0.416213990493497 1931 792097
SGTC_852 0418-0143 439 µM 0.209081658810375 0.424288101246118 no 1396 0.417192246216112 2034 5369229
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.208907863310885 0.424355106522621 no 1397 0.417260082782597 1951 2346 DNA damaging agent; causes G2/M arrest.
SGTC_118 0083-0097 135.343 µM 0.208591350283874 0.424477140861068 no 1398 0.417383631761031 1911 5207356
SGTC_1367 1812-0510 76.9 µM 0.207588152581603 0.424863980208461 no 1399 0.417775277864139 1984 1142582 YDR527W RBA50
SGTC_669 0108-0021 26.2 µM 0.204558930205546 0.426032505123493 no 1400 0.418958372872888 2152 17201
SGTC_1360 1598-0022 39.8 µM 0.203738920523865 0.426348936686781 no 1401 0.419278762934235 2006 761525
SGTC_2010 4012422 159 µM 0.20287867244453 0.426680946712305 no 1402 0.419614932272475 1973 952393
SGTC_537 1334-0398 209 µM 0.200804514602331 0.427481674593635 no 1403 0.420425716346028 2072 5846986
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.199672180747555 0.427918937974064 no 1404 0.420868486084664 1913 4330530
SGTC_3283 9109332 35.8195 µM 0.196899149424293 0.428990147864547 no 1405 0.421953229655561 1996 17027281
SGTC_1335 1486-0900 202 µM 0.195820937390336 0.429406798173374 no 1406 0.422375160831697 2028 X1335
SGTC_1488 4013-0813 75.9 µM 0.195677221295494 0.429462339912326 no 1407 0.422431407252271 1945 2910057
SGTC_737 1950-0117 57.9 µM 0.195480668974821 0.429538303447044 no 1408 0.422508334840147 2082 5393513
SGTC_384 k007-0144 5.16 µM 0.194662175507299 0.429854662799446 no 1409 0.422828712480405 1963 6824886
SGTC_2085 5307070 144.047 µM 0.193935728934539 0.43013548245653 no 1410 0.423113103563469 1912 2840351
SGTC_794 k038-0031 316 µM 0.19213220895916 0.430832814734029 no 1411 0.423819322894135 1998 6624242
SGTC_879 0831-1030 162 µM 0.191914338022339 0.430917069332089 no 1412 0.423904653044153 1911 1549252
SGTC_501 nsc-95397 161 µM 0.191491046576818 0.431080772709754 no 1413 0.424070447273433 2052 262093
SGTC_1605 st000082 49.1 µM 0.191370715252443 0.43112731170766 no 1414 0.424117580940704 2033 1114022
SGTC_3085 9117376 49.47 µM 0.190913563170482 0.431304127247934 no 1415 0.424296656872976 1978 16480349
SGTC_709 3807-1509 243 µM 0.189676282365327 0.431782746958645 no 1416 0.424781403665875 2039 1886677 YPL242C IQG1
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.188883130176618 0.43208961626975 no 1417 0.425092207873449 1930 2724 A muscle relaxant with antifungal properties.
SGTC_729 4092-0585 94.1 µM 0.188278173652229 0.432323700536258 no 1418 0.425329297138471 1914 2169061
SGTC_4 0960-0234 25.671 µM 0.188205980354405 0.432351636884369 no 1419 0.425357592309087 1961 6821112
SGTC_611 3453-1652 23.7 µM 0.186843509138922 0.432878930121904 no 1420 0.425891666106751 2077 1560575
SGTC_465 cgp-37157 41 µM 0.186460410541512 0.433027215595889 no 1421 0.426041861095419 2098 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1709 st033179 39.1045 µM 0.186451476754587 0.433030673697734 no 1422 0.426045363742285 2031 573381
SGTC_2138 5575593 77.673 µM 0.186032138315931 0.433192997530327 no 1423 0.42620977924512 1940 762213
SGTC_975 1335-0046 28.5 µM 0.185834819635441 0.433269382515645 no 1424 0.426287148998817 1892 16486740
SGTC_1269 0831-0796 3.05 µM 0.182897969733557 0.434406573779441 no 1425 0.427439037972789 2071 927758
SGTC_1591 genipin 88.4 µM 0.1800202202323 0.435521407294326 no 1426 0.42856834703577 2077 442424 A DNA cross-linking agent.
SGTC_166 k072-0058 166.424 µM 0.179053386074183 0.435896072103809 no 1427 0.428947891470132 2134 5846229
SGTC_1711 st032263 62.8 µM 0.178957163639992 0.435933363100037 no 1428 0.428985668549634 2026 3958979
SGTC_3161 9100388 49.47 µM 0.178511357179308 0.436106142783606 no 1429 0.429160701352979 2033 25236368
SGTC_1749 st037932 54.2 µM 0.177323172585504 0.43656670289037 no 1430 0.429627275057785 1973 594497
SGTC_2414 st077232 92.9 µM 0.176233258760256 0.43698924725848 no 1431 0.4300553464829 1852 729801
SGTC_2273 7815444 169.05 µM 0.176045748421547 0.437061949659539 no 1432 0.430129000809506 2122 2824616
SGTC_2896 9052656 71.43 µM 0.175842027893533 0.437140939561373 no 1433 0.430209025277122 2066 6469436
SGTC_199 4063-0024 41.6 µM 0.175237408801603 0.437375387245915 no 1434 0.430446545558548 2083 306215
SGTC_121 0557-0495 61.343 µM 0.174057107494819 0.437833125316947 no 1435 0.430910290918198 2052 3104427
SGTC_2701 st077767 14.721 µM 0.173660951660709 0.437986779010075 no 1436 0.431065963603786 1982 5721188
SGTC_225 nsc-122657 1.016 µM 0.172764340953888 0.438334574497363 no 1437 0.431418333652134 2074 275685
SGTC_1247 0448-0043 5.84 µM 0.17223246126723 0.438540913268706 no 1438 0.431627389392565 1973 3089013 YGL099W LSG1
SGTC_783 0848-0141 92.7 µM 0.171410816899366 0.438859696913007 no 1439 0.43195037499916 2052 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_679 0422-0091 41.4 µM 0.170213431155197 0.439324332604656 no 1440 0.432421144659583 1963 627384 YHR062C RPP1
SGTC_741 4582-0002 126 µM 0.169345891864684 0.439661026360918 no 1441 0.432762290364123 1967 2912688
SGTC_1751 st044839 27.194 µM 0.168957116477799 0.439811925053843 no 1442 0.432915186235467 2127 5291326
SGTC_2551 apiole 73.87 µM 0.168046335815243 0.440165468287967 no 1443 0.433273413327308 2099 10659 A possible DNA adduct former.
SGTC_1719 st032227 49.2 µM 0.166917216456148 0.440603831583582 no 1444 0.433717593210244 1966 3125804
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.164563319716554 0.441517929406813 no 1445 0.434643852072972 2021 65057 A dermal irritant. YDR527W RBA50
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.164414398997693 0.441575770896305 no 1446 0.434702464529904 1984 279621
SGTC_1837 st055472 66.5 µM 0.164392311347485 0.441584349946977 no 1447 0.434711157945173 2063 676091
SGTC_1881 5652484 16 µM 0.163367215196745 0.44198253699889 no 1448 0.435114657275704 2128 2255129
SGTC_2770 toltrazuril 17.5 µM 0.163254173757614 0.442026450269038 no 1449 0.435159156899908 2113 68591 Kills coccidiodes.
SGTC_1464 k208-0027 110 µM 0.162822802061138 0.44219403201202 no 1450 0.435328977198056 2107 X1464
SGTC_2086 5274770 176.623 µM 0.159786473606427 0.443373893256733 no 1451 0.43652463983536 2011 689278
SGTC_3241 9133421 49.47 µM 0.15935743784539 0.443540649377532 no 1452 0.43669363500446 2123 17018221
SGTC_2393 9031399 185.94 µM 0.158837077143333 0.443742914772247 no 1453 0.436898618141218 2076 1526623 YDL150W RPC53
SGTC_1565 sinapyl alcohol 95.1 µM 0.157923660221994 0.444097997430058 no 1454 0.437258476925479 1979 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3262 9137218 49.47 µM 0.15645093311537 0.444670601311741 no 1455 0.437838796296204 2125 17650664
SGTC_3099 9120367 49.47 µM 0.154462498382886 0.445443897983985 no 1456 0.438622539133131 2084 24824940
SGTC_2703 st077852 53.4 µM 0.153162683316966 0.445949504807585 no 1457 0.43913499239877 2046 6281836
SGTC_2869 9037858 32.47 µM 0.153104947311234 0.445971965215586 no 1458 0.439157757244201 2176 27187042
SGTC_955 1216-0110 33 µM 0.153059365171434 0.44598969766028 no 1459 0.439175730059627 2045 3619719
SGTC_1754 st042065 16.137 µM 0.152184335100922 0.446330124307538 no 1460 0.439520774414332 2060 1126236 YIL048W NEO1
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.150463652747145 0.446999663456356 no 1461 0.440199412570902 2150 1273210
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.150383017007639 0.447031043557882 no 1462 0.440231219680788 2105 6312947
SGTC_3096 9117468 49.47 µM 0.150348525602888 0.447044466290231 no 1463 0.440244825079655 2144 41316311
SGTC_359 0081-0058 15.9 µM 0.148460006644861 0.447779497636801 no 1464 0.440989873108769 2112 3494159
SGTC_330 1488-0319 80.1 µM 0.148200357822438 0.447880569757659 no 1465 0.441092324717545 2030 6846614
SGTC_2009 4012297 12.05 µM 0.14817944192259 0.447888711726492 no 1466 0.441100577834747 1997 45595307
SGTC_214 4373-3496 70 µM 0.14757376125163 0.448124495607819 no 1467 0.441339581911366 2100 3779166
SGTC_401 neomycin 50 µM 0.147539285057323 0.448137917309551 no 1468 0.441353187002473 2048 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2022 5136654 200 µM 0.14740695886341 0.448189432905808 no 1469 0.441405406573343 2047 1713771
SGTC_170 4197-0004 226 µM 0.147348908839141 0.44821203249866 no 1470 0.441428315037708 2070 218692
SGTC_373 0844-0104 25.9 µM 0.145762091268533 0.448829865064254 no 1471 0.442054601496537 2166 5375804
SGTC_2856 9022925 19.48 µM 0.145059115454351 0.44910361073489 no 1472 0.442332098965516 2064 4944862
SGTC_512 prima-1 270 µM 0.144790189307953 0.449208339625966 no 1473 0.442438264198228 2129 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2192 5915882 198.485 µM 0.143013386411725 0.449900375052135 no 1474 0.443139804520739 2139 2876149
SGTC_212 3807-4682 38.772 µM 0.142441495593502 0.450123149612773 no 1475 0.443365643889341 2124 3125501 YBL034C STU1
SGTC_2319 6033012 152.6 µM 0.141860508278523 0.450349483720431 no 1476 0.443595094298228 2049 847246
SGTC_2801 7907800 81.82 µM 0.141044827271943 0.450667274231864 no 1477 0.443917264623524 2039 6620925
SGTC_2430 5571206 200 µM 0.140264448138944 0.45097134069007 no 1478 0.444225526431533 2162 1731771
SGTC_302 1094-0063 18.9 µM 0.139849885326035 0.451132882410557 no 1479 0.444389298880308 2051 5440289
SGTC_919 tnp00227 403.569 nM 0.139395030389924 0.45131013397936 no 1480 0.444568999598313 2056 1269246 A methoxyflavone. YNL221C POP1
SGTC_3153 9100258 49.47 µM 0.138910605383046 0.45149891932869 no 1481 0.444760395169293 2009 25236848
SGTC_824 1304-0008 100 µM 0.137610601437783 0.452005598182581 no 1482 0.445274088255599 2063 768245
SGTC_800 3448-7362 155 µM 0.137402469804886 0.452086725139174 no 1483 0.445356339471403 2184 15991913
SGTC_2610 ononetin 44.17 µM 0.136068735503272 0.452606644466767 no 1484 0.445883471535935 2042 259632
SGTC_2914 7968218 45.32 µM 0.136000083250776 0.452633408850309 no 1485 0.445910607575817 2126 2977111
SGTC_1962 st076595 64.5 µM 0.135635874789959 0.452775400722205 no 1486 0.446054571767231 2111 279619
SGTC_1648 st011736 69.8 µM 0.134923304894959 0.453053223725632 no 1487 0.446336256694715 2141 2855514
SGTC_2629 bisabolol 100 µM 0.133592293398727 0.453572231619422 no 1488 0.446862489269099 2103 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2150 5556613 200 µM 0.133245144410288 0.453707610216175 no 1489 0.446999754525764 2092 743190
SGTC_26 0302-0163 425.158 µM 0.131988468871622 0.454197724123012 no 1490 0.447496706229178 2088 3100915
SGTC_364 0083-0097 67.7 µM 0.131147370738043 0.454525798398578 no 1491 0.44782936415726 2065 5207356
SGTC_3154 9100113 49.47 µM 0.130505321740719 0.454776253516194 no 1492 0.448083322006171 2056 25237525
SGTC_2139 5578692 56.4705 µM 0.129311838658269 0.455241863729128 no 1493 0.448555452095115 2198 650991 YMR113W FOL3
SGTC_459 nigericin 15.3 µM 0.127368120756256 0.45600029228817 no 1494 0.449324523330597 2097 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1512 0259-0544 12.2 µM 0.127048797166983 0.456124906091628 no 1495 0.449450888443952 2064 18476
SGTC_2507 purpurin 79.67 µM 0.125049003350502 0.456905409341923 no 1496 0.450242377856388 2085 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2464 5717415 7.67 µM 0.124307431027123 0.457194881405959 no 1497 0.450535931915101 2097 5285744
SGTC_2143 5623677 140.463 µM 0.123440355138287 0.457533372462472 no 1498 0.45087920131749 2172 5375313
SGTC_1296 1068-0102 11.9 µM 0.122447580769668 0.457920971792981 no 1499 0.451272278990275 2163 767053
SGTC_793 0488-0545 106 µM 0.121267417055707 0.458381783775176 no 1500 0.451739613470519 2011 292548
SGTC_1166 k206-0078 225 µM 0.120074125857092 0.458847778448425 no 1501 0.452212214324845 2154 5404595
SGTC_254 nsc-64875 3.808 µM 0.119744863733492 0.458976369280344 no 1502 0.452342629951769 2185 56993
SGTC_2341 7987486 176.74 µM 0.119297961434218 0.459150910457622 no 1503 0.452519649253406 2189 1258686
SGTC_3040 9091894 49.47 µM 0.119057983489067 0.45924463896676 no 1504 0.452614709112965 2154 25236966
SGTC_251 melphalan 456.522 µM 0.117858037208358 0.459713337482046 no 1505 0.453090071449136 2126 460612 A DNA alkylator.
SGTC_2992 9074591 71.4286 µM 0.117665680436952 0.459788477180842 no 1506 0.453166280434181 2222 17741321
SGTC_275 trichlorophene 5.69 µM 0.116627041832278 0.460194221941358 no 1507 0.453577803836036 2114 62616
SGTC_790 1575-0012 79.1 µM 0.116157325954027 0.46037773035381 no 1508 0.453763928351002 2211 378741 YLR208W SEC13
SGTC_1285 0929-0069 65.5 µM 0.115061730440567 0.460805789905577 no 1509 0.454198096534352 2101 1206237
SGTC_1380 2291-0730 164 µM 0.114974993318267 0.460839680868186 no 1510 0.454232471508928 2080 2999191
SGTC_981 1488-1094 54.9 µM 0.114536678039606 0.461010948985489 no 1511 0.454406186413109 2163 3449522
SGTC_756 0508-1999 28.3 µM 0.112799450090364 0.461689827455391 no 1512 0.455094777162916 2021 6753853
SGTC_205 1486-1330 71.903 µM 0.111829988483812 0.462068724851714 no 1513 0.455479104643302 2134 4118834
SGTC_1825 st052143 62.6 µM 0.111262565746875 0.462290508263301 no 1514 0.455704069626824 2202 674173
SGTC_3253 9135987 49.47 µM 0.108499247289135 0.463370747966464 no 1515 0.456799838783557 2168 4182430
SGTC_1365 1672-3266 55.4 µM 0.108098771319106 0.463527325104134 no 1516 0.456958671394651 2204 6415873
SGTC_931 2812-0076 566 µM 0.107440805503696 0.463784587261823 no 1517 0.457219641865661 2183 3450959
SGTC_3287 9117173 37.0625 µM 0.106755688406276 0.4640524815614 no 1518 0.457491401016453 2243 2789709
SGTC_2068 5226020 147 µM 0.104922486523128 0.46476937948032 no 1519 0.458218657892362 2148 1810509
SGTC_203 k066-0004 30.888 µM 0.104785963123096 0.464822773372098 no 1520 0.458272824265307 2230 6795412
SGTC_1745 st081495 74 µM 0.104012708011914 0.465125203049616 no 1521 0.458579631869001 2153 13842402 YBL026W LSM2
SGTC_3005 9076496 71.4286 µM 0.103183519578539 0.46544953132397 no 1522 0.45890865978071 2242 21368410
SGTC_79 0052-0007 94.094 µM 0.10269093615746 0.465642210993278 no 1523 0.459104133755547 2219 2801472
SGTC_2785 7756463 72.73 µM 0.102299797419881 0.465795215147593 no 1524 0.459259358050477 2176 2201551
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.102140132318534 0.465857673785346 no 1525 0.459322723294535 2230 88881 An O-methylated flavonoid and antioxidant.
SGTC_2129 girgensonine 121.053 µM 0.101950643203852 0.465931800229344 no 1526 0.459397925940444 2144 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2560 caryophyllene 100 µM 0.101839655545586 0.465975218155955 no 1527 0.45944197434637 2250 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2894 9048625 32.47 µM 0.101472812139659 0.466118728703101 no 1528 0.459587569454393 2228 4092861
SGTC_2618 avocadyne 43.43 µM 0.101311006400544 0.466182029130004 no 1529 0.459651789652952 2153 3015189
SGTC_2973 9094665 17.96 µM 0.100806931637721 0.466379234952526 no 1530 0.459851862111707 2214 25237061 YIL048W NEO1
SGTC_2898 9056270 58.44 µM 0.100461949407499 0.466514204820725 no 1531 0.459988794970745 2184 19154699
SGTC_1946 st076057 65.1 µM 0.100310916593927 0.466573295682802 no 1532 0.46004874550958 2218 953009
SGTC_2288 7946289 167.31 µM 0.0999237459523717 0.466724777696906 no 1533 0.460202432076811 2216 1246052
SGTC_837 0091-0265 12.5 µM 0.0995849362836651 0.466857342248281 no 1534 0.460336926737159 2101 759367
SGTC_2304 7443016 91.4 µM 0.0987880093329599 0.467169166778054 no 1535 0.460653294543759 2207 939854
SGTC_1515 3460-0031 42.1 µM 0.0975978946147164 0.467634876730811 no 1536 0.461125798189985 2178 2876596
SGTC_3023 9089636 49.47 µM 0.09747761773198 0.467681945376153 no 1537 0.461173554017435 2259 17249241
SGTC_1008 4106-0037 6 µM 0.0973488682003179 0.467732330172704 no 1538 0.461224674522914 2225 2905394
SGTC_3212 9128307 49.47 µM 0.0969708803483157 0.467880254789777 no 1539 0.461374759777697 1943 27243542
SGTC_613 3914-0030 117 µM 0.0967385312688726 0.467971186233535 no 1540 0.461467019894222 2214 1145395
SGTC_3239 9133757 49.47 µM 0.0966761783218436 0.4679955887818 no 1541 0.461491779072191 2210 17036923
SGTC_3286 9117135 37.221 µM 0.0946663228446822 0.468782232915051 no 1542 0.462289934142675 2132 3438150
SGTC_635 k038-0028 24.7 µM 0.0946209866854964 0.46879997860502 no 1543 0.462307939830282 2171 4035102
SGTC_2651 TUB2.036 5 µM 0.0937852570660832 0.469127114840484 no 1544 0.462639871609289 2234 15992207 YFL037W TUB2
SGTC_153 4077-0274 519.67 µM 0.0932801963511097 0.469324824857775 no 1545 0.462840482250392 2252 3121976
SGTC_357 1325-0123 420 µM 0.0931121897177028 0.469390594064118 no 1546 0.462907216757269 2232 1098503
SGTC_1230 0170-0365 3.77 µM 0.0920166453204533 0.469819484943643 no 1547 0.463342407322722 2239 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1215 3852-0577 11.2 µM 0.0918846180756864 0.469871174206349 no 1548 0.463394856377211 2218 2884876
SGTC_1220 1838-0075 193 µM 0.0914093441298011 0.47005725030031 no 1549 0.463583668646806 2172 5529645
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0909054377836188 0.470254543501911 no 1550 0.463783864679722 2147 75037 A free radical scavenger.
SGTC_1486 3970-0793 4.53 µM 0.0894431685850854 0.470827103300592 no 1551 0.464364858679638 2251 2844330
SGTC_2259 7964009 200 µM 0.0878681048870665 0.47144389586029 no 1552 0.464990753567919 2192 313134
SGTC_521 r062-0005 13.8 µM 0.0867492871920694 0.471882064872883 no 1553 0.465435399269171 2190 2832033
SGTC_561 1550-0330 72.9 µM 0.0863183980412654 0.472050825577585 no 1554 0.465606656769285 2169 6812934
SGTC_219 mitoxanthrone 164.414 µM 0.0862644793100022 0.472071943574044 no 1555 0.465628087294055 2211 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_814 3342-0569 96 µM 0.0859827445601749 0.472182290054534 no 1556 0.465740067133495 2249 4346283
SGTC_2186 6124449 200 µM 0.0851357076570285 0.47251406011355 no 1557 0.466076751370684 2220 3834182 YLR033W RSC58
SGTC_2210 7115885 190.385 µM 0.0849431632453168 0.472589479178416 no 1558 0.466153288230296 2233 2927039
SGTC_2925 9010536 32.5 µM 0.0847060471200554 0.472682358198947 no 1559 0.466247544171292 2172 2994177
SGTC_2460 5552655 174.22 µM 0.0845739049501223 0.472734119285234 no 1560 0.466300072776969 2115 5401989
SGTC_2440 5628896 157.78 µM 0.0843425795668234 0.472824732293505 no 1561 0.466392029693827 2196 5522048
SGTC_46 0329-0187a 2.197 µM 0.081982556590118 0.473749261969983 no 1562 0.467330292290681 2193 46494817
SGTC_3305 9127027 53.8275 µM 0.0819195006821968 0.473773965834488 no 1563 0.467355363627677 2182 41905295
SGTC_3216 9129716 49.47 µM 0.081454460039079 0.473956161245286 no 1564 0.467540270052027 2202 8056934
SGTC_2154 5570129 200 µM 0.0811503084136887 0.474075325887226 no 1565 0.467661208626646 2256 673366
SGTC_2994 9053520 71.4286 µM 0.080810413055516 0.474208497436829 no 1566 0.467796363367796 2239 4647384
SGTC_2446 5162541 200 µM 0.0806083151504936 0.474287681089231 no 1567 0.467876726596946 2233 1549321
SGTC_2053 5265679 138 µM 0.0804807150332519 0.474337676407558 no 1568 0.467927466824882 2236 764595
SGTC_1682 st012968 530 nM 0.0797957189638624 0.474606073304701 no 1569 0.46819986462017 2084 24207270
SGTC_865 0488-0499 301 µM 0.0790606108404512 0.474894118051684 no 1570 0.468492206699986 2273 9634651
SGTC_3078 9116413 49.47 µM 0.0779122409356991 0.475344121490979 no 1571 0.468948931076602 2261 17177322
SGTC_733 4069-0007 56.1 µM 0.0773816866690217 0.475552036625661 no 1572 0.469159954507859 2275 5717425 YNL287W SEC21
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0756604783434301 0.476226594244113 no 1573 0.469844609769623 2267 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2918 7977171 22.06 µM 0.0756587316774627 0.476227278813753 no 1574 0.469845304596952 2285 2236483
SGTC_148 3253-0744 288.01 µM 0.0739890432333406 0.476881710502233 no 1575 0.470509551798591 2296 6893655
SGTC_956 1185-0240 191 µM 0.0735745528047285 0.47704417908567 no 1576 0.470674460082741 2222 1416193
SGTC_2552 juarezic acid 87.02 µM 0.0723633419849145 0.477518961408907 no 1577 0.471156378570941 2295 1549512
SGTC_3273 9137859 49.47 µM 0.0723320143367569 0.47753124195463 no 1578 0.471168843828868 2310 2377234
SGTC_1090 efavirenz 20.7 µM 0.0717103063517618 0.477774958019072 no 1579 0.471416226999324 2214 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1074 carmofur 3.8 µM 0.0716093100365554 0.477814550423347 no 1580 0.471456415380782 2285 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1673 st016611 27.3 µM 0.0712323266552904 0.477962336740279 no 1581 0.471606426901992 2243 5226799
SGTC_801 0866-0028 10.1 µM 0.0710373059106091 0.478038790631525 no 1582 0.471684032325868 2284 6849771
SGTC_2909 7941780 10.49 µM 0.0706277840708762 0.478199337913756 no 1583 0.471846998566991 2279 1243215
SGTC_1661 st013063 9.66 µM 0.0691773988238902 0.478767969342836 no 1584 0.472424206563708 2278 721395
SGTC_2056 5235370 200 µM 0.0691565888611416 0.47877612831925 no 1585 0.472432488702809 2224 5511916
SGTC_2334 9017922 200 µM 0.0689999874601873 0.478837527423339 no 1586 0.472494814741215 2261 3163164
SGTC_2401 5128683 200 µM 0.0676727196255164 0.479357932673165 no 1587 0.47302308304926 2234 708373
SGTC_2377 9073351 62.6 µM 0.0673290846481704 0.47949267345463 no 1588 0.473159861607874 2221 7337946 YHR072W ERG7
SGTC_2890 9046729 58.44 µM 0.0673117322490168 0.479499477468714 no 1589 0.473166768544569 2194 903329
SGTC_1907 st060210 83.7 µM 0.0668374225798969 0.479685460378857 no 1590 0.473355565547024 2245 688793
SGTC_1594 piperine 70.1 µM 0.0654761570101989 0.4802192545054 no 1591 0.473897444770385 2295 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1226 3909-7979 35.4 µM 0.0654466511391343 0.480230825061809 no 1592 0.473909190716055 2284 6615510
SGTC_1743 st037606 46.3785 µM 0.0644276186511877 0.48063044290337 no 1593 0.474314869600996 2254 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_490 phenamil 164 µM 0.0642482076741496 0.480700801693288 no 1594 0.474386296241581 2284 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2314 7727897 200 µM 0.0641152676949088 0.480752936550492 no 1595 0.474439222498235 2250 900724
SGTC_3353 9151644 39.2805 µM 0.0638903311775386 0.480841150290952 no 1596 0.474528775576515 2238 4909158
SGTC_1086 cerivastatin 2.18 µM 0.0634097549925481 0.481029621817068 no 1597 0.474720109762236 2312 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_277 nystatin 15.5 µM 0.0628562341767837 0.481246705892784 no 1598 0.474940492979032 2290 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2513 baicalein 25.65 µM 0.062804472059808 0.481267006645598 no 1599 0.474961102356503 2232 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_914 3820-6779 408 µM 0.0625416028085249 0.481370102939918 no 1600 0.475065766257602 2293 2893481
SGTC_1298 1079-1278 263 µM 0.0608532273693526 0.482032306602306 no 1601 0.475738049759884 2275 2840950
SGTC_1150 3909-7983 10.9 µM 0.0601051359010555 0.482325734143253 no 1602 0.476035949751679 2220 23965914
SGTC_2939 9044578 71.43 µM 0.0600841976820345 0.482333946980818 no 1603 0.476044287822995 2296 2653634
SGTC_2151 5563267 85.4165 µM 0.0599510863565486 0.482386158936428 no 1604 0.476097296001826 2206 5310824
SGTC_1268 0828-0275 2.46 µM 0.0592980623358445 0.482642307249484 no 1605 0.476357352216495 2261 745337
SGTC_2841 9004761 38.96 µM 0.0587356828829897 0.482862906026742 no 1606 0.476581318778312 2227 2991039
SGTC_2787 5284540 71.43 µM 0.0581643358693772 0.483087027788672 no 1607 0.476808864230012 2227 736958
SGTC_1100 amiodarone 5.07 µM 0.058011295349925 0.483147061761408 no 1608 0.476869815646024 2318 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2878 9043973 25.97 µM 0.0566230713401252 0.483691644647437 no 1609 0.477422727877442 2284 6465167
SGTC_911 3456-4043 236 µM 0.0533450152746442 0.484977703887162 no 1610 0.478728507117833 2269 914281
SGTC_2122 5258151 111.688 µM 0.0519924989275972 0.485508374474043 no 1611 0.479267335160113 2270 2173356
SGTC_638 3970-0837 4.09 µM 0.0519264264847732 0.485534299189641 no 1612 0.479293658693176 2285 4118451 YLR208W SEC13
SGTC_2115 tiliquinol 12.7705 µM 0.0518181408781207 0.485576787134208 no 1613 0.47933680031963 2269 71208 A bioactive hydroxyquinoline.
SGTC_625 k213-0058 121 µM 0.0512869714768439 0.485785204047511 no 1614 0.479548424848781 2251 3655420
SGTC_1645 Cervolide 78 µM 0.0505042633894409 0.48609232519069 no 1615 0.479860276024421 2271 23173 A fragrance.
SGTC_1004 4084-0029 199 µM 0.0501908490109656 0.486215305906109 no 1616 0.479985151897974 2320 716894 YLR208W SEC13
SGTC_53 0973-0023 39.979 µM 0.0500257205680558 0.486280101208886 no 1617 0.48005094596441 2340 674768
SGTC_3199 9111318 49.47 µM 0.0498586403840111 0.486345662730556 no 1618 0.480117518239178 2303 8548020
SGTC_1153 4055-0057 267 µM 0.0492745749183978 0.48657485031193 no 1619 0.480350240587179 2290 882706
SGTC_2667 digitoxin 100 µM 0.0490904647312436 0.486647096164389 no 1620 0.480423601144637 2326 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1193 1488-0126 41.5 µM 0.0484023097372993 0.486917135838973 no 1621 0.480697809280082 2328 1384710
SGTC_318 1488-0629 67.2 µM 0.0474160331947072 0.487304172154142 no 1622 0.481090825375558 2242 3662576
SGTC_1626 st003712 1.76 µM 0.0462695697526291 0.48775408428827 no 1623 0.481547696571115 2271 24207035
SGTC_1578 josamycin 24.2 µM 0.0459006798973029 0.487898852840926 no 1624 0.481694706135161 2191 5282165 A P450 substrate.
SGTC_3050 9093513 49.47 µM 0.0453821045154636 0.48810236724885 no 1625 0.48190137240905 2324 25236664
SGTC_2836 9010338 19.48 µM 0.0448071860158194 0.48832799707801 no 1626 0.482130498617545 2291 2994051
SGTC_1744 st037937 38.9 µM 0.0440179638125173 0.488637737607179 no 1627 0.482445042346789 2289 1016152
SGTC_2318 6029776 164 µM 0.043607565821037 0.488798806362381 no 1628 0.48260861039167 2314 818325
SGTC_1382 3002-2117 298 µM 0.0433718453848854 0.488891320306616 no 1629 0.482702560351425 2318 1497314
SGTC_3229 9132204 49.47 µM 0.0428029652162005 0.489114592955745 no 1630 0.482929300128448 2295 17682924
SGTC_3007 9078383 71.4286 µM 0.0426503793963206 0.489174480035333 no 1631 0.482990117524823 2299 6496995
SGTC_62 0180-0423 3.232 µM 0.0421003255020869 0.489390367913949 no 1632 0.483209360344647 2280 30102 YGL099W LSG1
SGTC_731 3966-0296 387 µM 0.0411911267484945 0.489747221532293 no 1633 0.483571763749803 2331 660956
SGTC_1934 st074720 32.6 µM 0.041104528383738 0.489781211166558 no 1634 0.483606282264132 2330 17250992
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.040097976492015 0.490176285561657 no 1635 0.48400750751568 2293 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2328 6201408 200 µM 0.0391778430400226 0.490537448922939 no 1636 0.484374299382084 2299 2890418
SGTC_772 k072-0172 35.3 µM 0.0390413740287378 0.490591015306386 no 1637 0.48442870101937 2281 5861980
SGTC_994 3910-0338 138 µM 0.0377750573922327 0.491088073861763 no 1638 0.484933515745909 2319 3479481
SGTC_353 1988-1175 58.3 µM 0.0370351465356481 0.491378512433937 no 1639 0.4852284910353 2296 2788357
SGTC_1116 jasmonic acid 1.58368 µM 0.0369728487213885 0.49140296652056 no 1640 0.485253327257491 2330 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1235 benzylparaben 21.5 µM 0.0366984148220771 0.491510691876802 no 1641 0.485362736290997 2307 7180
SGTC_2789 5281112 71.43 µM 0.0364655141500389 0.491602114406267 no 1642 0.485455588066221 2309 765948
SGTC_432 NS 1619 61.3 µM 0.0362228307648394 0.491697377498605 no 1643 0.485552340807691 2230 4552 A K+/calcium channel activator.
SGTC_1440 4100-1550 40 µM 0.0361991893182644 0.491706657752672 no 1644 0.485561766198812 2330 742806
SGTC_2364 9055074 200 µM 0.035782478978384 0.491870234677942 no 1645 0.485727901934873 2307 6470630
SGTC_3157 9099274 49.47 µM 0.0349693973944725 0.49218940846034 no 1646 0.486052071641487 2336 17217662
SGTC_3284 9108171 64.8615 µM 0.0349411394608873 0.492200501154844 no 1647 0.486063338040805 2293 8687505
SGTC_1999 st074831 12.5 µM 0.0320744359409786 0.493325859802063 no 1648 0.487206345040928 2283 17112523
SGTC_2228 7354201 200 µM 0.0310600604527921 0.493724078180376 no 1649 0.487610820715606 2297 753451
SGTC_1252 0493-0875 34.8 µM 0.0307407159190012 0.493849446149046 no 1650 0.487738159943183 2348 3960963
SGTC_7 0192-1582 4.227 µM 0.0300656520452152 0.494114464056944 no 1651 0.488007347018524 2344 252616
SGTC_1185 1319-0113 81.3 µM 0.0299252288514212 0.494169592001763 no 1652 0.488063342571625 2316 4672763
SGTC_1231 0242-0792 125 µM 0.0298848841867482 0.494185430705369 no 1653 0.488079430568694 2338 3707635
SGTC_1187 1391-0724 117 µM 0.0296880597246102 0.494262701135739 no 1654 0.488157917342544 2287 6997986
SGTC_2458 5808907 16.39 µM 0.0291770282843475 0.494463325668332 no 1655 0.488361701102991 2354 2731747
SGTC_2906 7926292 26.41 µM 0.0283507140382266 0.494787729216142 no 1656 0.488691216441145 2309 2966319
SGTC_2049 5262831 67.185 µM 0.0274720341220336 0.495132694832006 no 1657 0.489041622481797 2329 763417
SGTC_2469 5655019 90.81 µM 0.0271530933123855 0.495257910412572 no 1658 0.489168814005403 2351 2788239
SGTC_3140 9094243 49.47 µM 0.0262945226134766 0.495594985991229 no 1659 0.489511211861813 2371 19291112
SGTC_1616 st002734 56.1 µM 0.0254421819380904 0.495929618768841 no 1660 0.489851132832478 2292 4026101
SGTC_1935 st074532 41.6 µM 0.0254158106240904 0.49593997231206 no 1661 0.489861650063673 2332 2829742
SGTC_3263 9137018 49.47 µM 0.0253064214827792 0.495982919203909 no 1662 0.489905275985085 2338 43844957
SGTC_3307 9126885 69.2785 µM 0.0249439012759717 0.496125247336605 no 1663 0.490049854980625 2349 24824909
SGTC_869 0564-0080 44.1 µM 0.0232799814095087 0.496778520715571 no 1664 0.490713469953851 2287 6843321
SGTC_2427 5545055 42.75 µM 0.0223988621542449 0.497124461509434 no 1665 0.491064893997256 2356 5372858
SGTC_2833 9001315 45.46 µM 0.0217503102451336 0.49737909422929 no 1666 0.491323565738891 2312 2989378
SGTC_566 0958-0068 16.5 µM 0.0216535169243025 0.49741709705871 no 1667 0.491362171594786 2360 6815365
SGTC_305 1682-2595 20.8 µM 0.0212246316048126 0.497585485562536 no 1668 0.491533232763589 2343 226033
SGTC_750 4073-0104 132 µM 0.019718722204286 0.498176737338307 no 1669 0.49213387776196 2370 22330957
SGTC_1677 st019204 53.9 µM 0.0191931466593112 0.498383090385696 no 1670 0.492343512385376 2264 3945625
SGTC_2761 levamisole 97.89 µM 0.0191412276563389 0.498403475004798 no 1671 0.492364221266441 2373 26879 An alkaline phosphatase inhibitor.
SGTC_1326 1431-2094 10.8 µM 0.0179924926581718 0.498854496296316 no 1672 0.492822421216947 2371 616278
SGTC_2874 9043904 71.43 µM 0.0168738268309607 0.499293713112152 no 1673 0.493268636478878 2296 4463428
SGTC_2325 6158266 200 µM 0.0167356020713761 0.499347983758356 no 1674 0.493323772393933 2350 3623240
SGTC_3093 9117344 49.47 µM 0.0164690391433176 0.499452643350396 no 1675 0.493430100960952 2354 24824913
SGTC_1403 3909-7815 62.9 µM 0.0162090634072933 0.49955471667454 no 1676 0.493533802430404 2360 6615483
SGTC_854 0422-0053 192 µM 0.016143477931823 0.49958046726521 no 1677 0.493559963826472 2368 3596728
SGTC_2959 9079155 11 µM 0.015939191011963 0.499660675718644 no 1678 0.493641452030869 2356 16189457
SGTC_606 k015-0008 38.6 µM 0.0142107076366371 0.499660675718644 no 1679 0.49433093869565 2374 1970475
SGTC_3342 9147791 14.508 µM 0.0141175990851708 0.499624118834302 no 1680 0.494368079907601 2386 1838168
SGTC_636 0kpi-0074 126 µM 0.0137868850745906 0.499494271778659 no 1681 0.494500002867521 2367 616434
SGTC_559 1550-0661 158 µM 0.0134002244792776 0.499342458685063 no 1682 0.494654243874846 2358 5830875
SGTC_336 4111-0029 111 µM 0.0108171084572051 0.498328263078674 no 1683 0.495684682240667 2340 3131175
SGTC_2261 9010538 184.68 µM 0.0105317304321266 0.49821621711066 no 1684 0.495798525114385 2322 6457250
SGTC_3220 9131269 49.47 µM 0.0102363945720349 0.498100261616147 no 1685 0.49591634072334 2400 17722206
SGTC_1093 fluphenazine 7.97 µM 0.0101390536431652 0.498062043415027 no 1686 0.495955172120262 2386 6602611 An atypical antipsychotic.
SGTC_2370 9071495 200 µM 0.00946191953847987 0.497796186103894 no 1687 0.496225296565987 2332 21791103
SGTC_422 cantharidin 155 µM 0.0091931460706122 0.497690660164943 no 1688 0.496332517001502 2392 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2111 5486399 200 µM 0.00896243809214444 0.497600079641201 no 1689 0.496424552376109 2387 689674
SGTC_3047 9092122 49.47 µM 0.00765333720985868 0.497086103176056 no 1690 0.496946790007082 2388 17173831
SGTC_1785 bathophenanthroline 24 µM 0.00538240891362268 0.49619450800077 no 1691 0.497852739881756 2392 72812 An iron chelator.
SGTC_2693 st077581 40.7 µM 0.00365970560885938 0.495518165331904 no 1692 0.498539991957894 2403 25238761
SGTC_1136 pergolide 1.05886 µM 0.00350026790619125 0.495455569845941 no 1693 0.498603597990913 2394 47811 A dopamine receptor agonist.
SGTC_226 1,3-diallylurea 8.28947 mM 0.00348656490214292 0.495450190030789 no 1694 0.498609064665238 2380 74537 YKL182W FAS1
SGTC_920 mycophenolic acid 780.421 nM 0.00261258259323817 0.495107065322683 no 1695 0.498957731528199 2394 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_989 1501-0895 10.3 µM 0.00204309199792925 0.494883485733277 no 1696 0.499184924786327 2402 2830112
SGTC_923 1900-2434 73.3 µM 0.00197479833575479 0.494856674038052 no 1697 0.499212169960668 2398 5910570
SGTC_572 0960-0087 17.7 µM 0.00140311615950135 0.494632235858052 no 1698 0.499440237823331 2401 6796365
SGTC_1321 1326-2144 215 µM 0.00055130126029999 0.494297822823327 no 1699 0.499780062629169 2390 3513030
SGTC_1018 4259-0013 28.1 µM -0.00079240473188975 0.49377030706661 no 1700 0.499683876282342 2408 6801262
SGTC_2024 5144227 134 µM -0.000948684363623702 0.49370895507285 no 1701 0.499621529753365 2408 3475211
SGTC_1931 st074438 57.1 µM -0.00119763594370825 0.493611222390122 no 1702 0.499522212499744 2407 2787313
SGTC_1119 parthenolide 318.541 nM -0.00274408175263307 0.493004132038369 no 1703 0.498905271141879 2420 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3185 9108267 49.47 µM -0.00315848417981952 0.492841452203794 no 1704 0.49873994921374 2414 4910486
SGTC_3137 9097352 49.47 µM -0.00400282700064728 0.492509996588036 no 1705 0.498403107332712 2415 44120435
SGTC_1033 k072-0102 21.3 µM -0.00465130012904564 0.49225543517012 no 1706 0.498144406410525 2415 5965931
SGTC_1897 st060201 15 µM -0.00487791692355037 0.492166476335629 no 1707 0.498054000416123 2418 611878
SGTC_1161 k007-0610 110 µM -0.00558765058203704 0.491887871639435 no 1708 0.497770861534356 2418 5843850
SGTC_2116 5511452 16.8835 µM -0.00629193416818605 0.491611410271073 no 1709 0.497489897996654 2418 870744
SGTC_1293 1000-1278 195 µM -0.00640446504065213 0.491567237470414 no 1710 0.497445005578384 2425 678847
SGTC_2934 9036370 36.88 µM -0.00654838361766086 0.491510743909965 no 1711 0.497387591577231 2435 6462800
SGTC_2843 9000894 45.46 µM -0.0099652197058251 0.490169557251585 no 1712 0.4960245183239 2423 2242070
SGTC_714 4296-0578 26.1 µM -0.0111823526715654 0.48969183066244 no 1713 0.495538979696535 2436 1589775
SGTC_3270 9137563 49.47 µM -0.0119898092618288 0.489374910807071 no 1714 0.495216872751945 2502 17015724
SGTC_2880 9042983 58.44 µM -0.0121577646336666 0.489308990585934 no 1715 0.495149873136634 2443 6464714
SGTC_757 1066-0008 322 µM -0.0127180028773993 0.489089106743404 no 1716 0.494926387704407 2505 6842497
SGTC_3208 9114115 49.47 µM -0.0131016352766393 0.488938539555954 no 1717 0.494773353274309 2455 650895
SGTC_374 0880-0231 82.3 µM -0.0138630315691172 0.488639713129187 no 1718 0.49446962771429 2429 6833587
SGTC_2685 mycophenolic acid 18.85 µM -0.0142842319281069 0.488474406676257 no 1719 0.494301609724054 2438 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3156 9099931 49.47 µM -0.0144278866589063 0.488418027655281 no 1720 0.494244305683591 2441 18111053
SGTC_2678 equilin 100 µM -0.0148690466573187 0.488244890577649 no 1721 0.494068327190761 2424 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_140 0062-0056 502.533 µM -0.0148862147220687 0.488238152865919 no 1722 0.494061478881818 2433 3758964
SGTC_1223 0764-0573 147 µM -0.0152697170039612 0.488087645934732 no 1723 0.493908500998249 2447 1609797
SGTC_3006 9075424 71.4286 µM -0.0156624077145091 0.487933534727817 no 1724 0.493751858807151 2445 7465181
SGTC_2751 anetholtrithion 17.25 µM -0.0157432030533183 0.487901826873829 no 1725 0.493719630104141 2442 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3032 9089427 49.47 µM -0.016676947423208 0.487535387693844 no 1726 0.493347168947813 2450 17173707
SGTC_346 4513-0042 7.16 µM -0.0172112522720362 0.487325709503885 no 1727 0.493134042752257 2438 2827372
SGTC_2244 6635614 200 µM -0.0177862591896754 0.487100062445175 no 1728 0.492904683302807 2439 836499
SGTC_2614 arthonioic acid 13.39 µM -0.0178322467002324 0.487082015976214 no 1729 0.492886339849699 2437 6710684
SGTC_410 α-linolenic acid 100 µM -0.0179816176754542 0.487023399838176 no 1730 0.492826759005583 2506 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3098 9119039 49.47 µM -0.0181428738271572 0.4869601200355 no 1731 0.492762437601879 2432 17161528
SGTC_3178 9107506 49.47 µM -0.0182757468303423 0.486907978535408 no 1732 0.492709437730573 2458 8897194
SGTC_1379 2144-0755 36.5 µM -0.0183746335084414 0.486869173960231 no 1733 0.492669994277088 2435 5392327
SGTC_1301 naphtanilide LB 4.81 µM -0.018821788873981 0.486693705228609 no 1734 0.492491635946509 2434 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2356 9061756 188.97 µM -0.0210792813448252 0.485807880142012 no 1735 0.491591206157463 2431 20104043
SGTC_440 fluspirilene 35.1 µM -0.0226446032905137 0.485193699032062 no 1736 0.490966882328517 2610 3396 An atypical antipsychotic.
SGTC_511 blebbistatin 171 µM -0.0227931318621363 0.48513542308248 no 1737 0.4909076432915 2474 3476986 A myosin inhibitor.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0230504653030807 0.485034457734609 no 1738 0.490805009068036 2454 551469
SGTC_3193 9111931 49.47 µM -0.0244197481881609 0.484497232841239 no 1739 0.490258898122911 2470 17087244
SGTC_3224 9130643 49.47 µM -0.0248141558518329 0.48434249598702 no 1740 0.490101599899314 2486 17644395
SGTC_2860 9025725 38.96 µM -0.0250791543366873 0.484238531196466 no 1741 0.489995913691035 2463 40546248
SGTC_900 1112-0045 141 µM -0.0256653706237179 0.484008549345768 no 1742 0.489762122495877 2446 56211 YIL048W NEO1
SGTC_2185 6113692 200 µM -0.0264018038384924 0.483719642585253 no 1743 0.489468427698792 2489 874150
SGTC_1108 betulinic acid 729.144 nM -0.0268370663360687 0.483548890746271 no 1744 0.489294844597702 2467 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3100 9120536 49.47 µM -0.0272862298994314 0.483372688735053 no 1745 0.489115719864434 2446 16421196
SGTC_2429 5902844 64.44 µM -0.0281997074328059 0.483014351425869 no 1746 0.488751435283691 2488 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_532 1548-0774 215 µM -0.0283600152867571 0.482951467558768 no 1747 0.488687507271281 2493 5932993
SGTC_92 0063-0024 660.874 µM -0.0286845371606201 0.482824168855058 no 1748 0.488558094426142 2452 3594437
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0287308793194899 0.482805990571993 no 1749 0.488539614196254 2475 641818
SGTC_2571 chrysanthemic acid 100 µM -0.0300189949586349 0.482300725773806 no 1750 0.488025952105216 2491 2743 An insecticide.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0307666755651688 0.482007460207375 no 1751 0.487727808439074 2459 77254
SGTC_803 4488-1585 147 µM -0.0310991865193032 0.48187704130786 no 1752 0.487595219210312 2452 747204
SGTC_2673 kobusone 100 µM -0.0313255135988272 0.481788271420156 no 1753 0.487504971740021 2476 6710676 An epoxy ketone and protein crosslinker.
SGTC_1756 st041558 35.5 µM -0.0317653250348817 0.481615771396935 no 1754 0.487329599643467 2458 3955792
SGTC_3334 9142812 21.919 µM -0.031890986742159 0.481566485798123 no 1755 0.48727949326154 2530 45283678
SGTC_2149 5554786 194.827 µM -0.0321032089925349 0.481483251052359 no 1756 0.487194872162416 2469 745063 YPR165W RHO1
SGTC_665 3914-0008 307 µM -0.0327153023329677 0.481243189177426 no 1757 0.486950810463142 2478 1069549
SGTC_960 1222-0186 7.7 µM -0.0334800913577958 0.480943249906352 no 1758 0.486645870862921 2501 3126296
SGTC_2679 rapamycin 1 nM -0.0338454714021607 0.480799956898557 no 1759 0.486500187881735 2480 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1572 epiandrosterone 68.9 µM -0.0351875711204942 0.480273640048353 no 1760 0.485965086451983 2479 441302 A steroid.
SGTC_596 1155-0152 116 µM -0.0357074498072001 0.480069773990263 no 1761 0.485757815127329 2466 280313
SGTC_1373 2887-0003 58.5 µM -0.036392592153547 0.479801109147729 no 1762 0.485484660436764 2513 776948
SGTC_2684 capsaicin 100 µM -0.0367905691385965 0.479645054652797 no 1763 0.485325996848223 2506 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1474 0330-0125 5.35 µM -0.0370085450722372 0.479559583382253 no 1764 0.485239096213465 2486 X1474
SGTC_1531 st059297 52.4 µM -0.0374347224384644 0.479392476272168 no 1765 0.485069193780851 2514 7566702
SGTC_988 1497-1057 103 µM -0.0374351064197749 0.479392325712054 no 1766 0.485069040701769 2458 3533044
SGTC_1404 3909-7820 48.3 µM -0.0377271515135554 0.479277814891078 no 1767 0.484952613812776 2479 23741373
SGTC_438 sphingosine 6.67 µM -0.037783845301554 0.479255585466454 no 1768 0.484930012378372 2485 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2073 5212005 126 µM -0.0379834775575683 0.479177310911182 no 1769 0.484850427760343 2458 691789
SGTC_2812 7970281 58.44 µM -0.0380924557985586 0.479134581565173 no 1770 0.484806983173463 2511 2233435
SGTC_2365 9042475 200 µM -0.0382585151385293 0.479069471716975 no 1771 0.4847407833381 2497 6464479
SGTC_899 1083-0020 478 µM -0.0389766463658312 0.478787907646591 no 1772 0.484454503981119 2540 767123
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0403083242085841 0.478265813041868 no 1773 0.483923658707631 2481 641818 YHR062C RPP1
SGTC_270 tamoxifen 5.46 µM -0.0404077255749487 0.478226843451628 no 1774 0.4838840355815 2477 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3319 9138450 16.7555 µM -0.0417686550417512 0.477693321943302 no 1775 0.483341561424816 2508 2029690
SGTC_2837 9008476 45.46 µM -0.0420393529125183 0.477587205723213 no 1776 0.483233663372432 2544 2992805
SGTC_445 e6 berbamine 66 µM -0.0429211730694147 0.477241534632684 no 1777 0.482882185316489 2527 6610268 A calcium/calmodulin antagonist.
SGTC_1084 voriconazole 435 nM -0.0443747661782004 0.47667176760623 no 1778 0.482302837751414 2487 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_111 0083-0039 52.457 µM -0.0444343023882876 0.476648432119179 no 1779 0.482279109644632 2465 759313
SGTC_1564 D-Arginine 115 µM -0.0445175231351553 0.476615813504942 no 1780 0.482245942190721 2504 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_885 0865-0106 16.8 µM -0.0446637270368994 0.476558508839184 no 1781 0.482187673230394 2492 2793380
SGTC_227 fluconazole 33.516 µM -0.0456518787890875 0.476171215215977 no 1782 0.481793859475628 2488 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1499 4480-0877 67.3 µM -0.0456592958717729 0.47616830826857 no 1783 0.481790903570047 2483 2861909
SGTC_87 0100-0052 35.5 µM -0.0457245184269193 0.476142745909307 no 1784 0.481764910682665 2503 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1056 3448-1962 115 µM -0.0465131703413252 0.475833661196808 no 1785 0.481450618516933 2544 715507
SGTC_491 tetrandrine 80.3 µM -0.0465975067704698 0.475800609321416 no 1786 0.481417009591307 2506 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2504 purpurogallin 52.29 µM -0.047608935290117 0.47540423837948 no 1787 0.48101395538737 2532 5281571 An antioxidant.
SGTC_1520 flindersine 88 µM -0.048187476943826 0.475177523339369 no 1788 0.480783415272647 2606 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2735 sertaconazole 140 nM -0.0488478953366506 0.474918732817256 no 1789 0.480520256373651 2482 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2231 micatex 6.853 µM -0.0503760901942748 0.474319937517652 no 1790 0.479911344725028 2521 20737 An antifungal of unknown mechanism.
SGTC_1498 4478-3555 97.6 µM -0.0509698286757029 0.474087307489003 no 1791 0.479674781257588 2481 3437919
SGTC_2362 9071156 126 µM -0.0513276098092155 0.473947131118573 no 1792 0.47953223382476 2538 653133
SGTC_2848 9016370 25.97 µM -0.0515091051909349 0.473876023615524 no 1793 0.479459923295607 2497 7894410
SGTC_2940 9060638 45.86 µM -0.0515308075920955 0.473867520955905 no 1794 0.479451276773074 2535 4027022
SGTC_1477 0139-0234 16 µM -0.0521816837106528 0.473612523473937 no 1795 0.479191963664722 2489 620880
SGTC_1399 3562-5772 25 µM -0.0523040287443493 0.473564592860145 no 1796 0.479143221619643 2498 23847490
SGTC_816 0325-0417 81.3 µM -0.0527019225151343 0.473408714293699 no 1797 0.478984703605449 2537 68101
SGTC_2606 farnesol 9.78 µM -0.0535557036715617 0.473074251398009 no 1798 0.47864457458928 2525 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3206 9114350 49.47 µM -0.0542724320829987 0.472793492618681 no 1799 0.478359056591582 2487 17087243
SGTC_2910 7948405 25.97 µM -0.0544130649216127 0.472738405127058 no 1800 0.478303034987054 2511 2971328
SGTC_1140 3229-1848 2.98 µM -0.0549556379012569 0.472525877980117 no 1801 0.478086903087699 2497 2849525
SGTC_1967 st070177 51.4 µM -0.0551283138907489 0.472458242015706 no 1802 0.478018119607595 2552 5729214
SGTC_2225 6654152 15.4 µM -0.0562312175265675 0.472026261275563 no 1803 0.477578806253973 2511 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1198 1612-1005 86.7 µM -0.0566488775102454 0.471862682500695 no 1804 0.477412449203423 2585 6998509
SGTC_3155 9099265 49.47 µM -0.0569718831139594 0.471736178875119 no 1805 0.477283796387744 2563 25236499
SGTC_2624 nerol 100 µM -0.0570323677865829 0.471712490654132 no 1806 0.47725970566463 2496 637566 A natural product oil.
SGTC_1775 st081588 35.1725 µM -0.0571317968623374 0.471673550462152 no 1807 0.477220103773702 2512 1426443 YGL099W LSG1
SGTC_2563 tomatine 8.54 µM -0.058913517388724 0.470975807477498 no 1808 0.476510495716927 2480 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2243 6634756 200 µM -0.0596765970307044 0.470677003521776 no 1809 0.476206605685693 2636 885676
SGTC_2391 6285546 200 µM -0.0602112643297154 0.470467650267818 no 1810 0.475993687177904 2513 846083
SGTC_2270 7924575 90.91 µM -0.0606234442285203 0.470306263502909 no 1811 0.475829551033372 2558 1262135
SGTC_850 0388-0143 75.9 µM -0.0617278616466136 0.46987385907226 no 1812 0.475389775943263 2528 67273
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.0621564178993785 0.469706079132825 no 1813 0.475219134411178 2501 4000243
SGTC_282 k297-0036 65.7 µM -0.0645759872615478 0.468758918557632 no 1814 0.474255802091858 2582 5061378
SGTC_631 k072-0230 41.5 µM -0.0648983875431469 0.468632725513867 no 1815 0.474127452221809 2583 5773147
SGTC_1801 st050089 28.441 µM -0.0649839202138489 0.46859924707632 no 1816 0.47409340150084 2514 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2927 9011802 47.9 µM -0.0667652534123672 0.467902064293747 no 1817 0.473384292711408 2583 43912568
SGTC_3210 9128157 49.47 µM -0.0668139198348686 0.467883018475502 no 1818 0.473364920873481 2662 17590849
SGTC_2306 7482397 179.52 µM -0.0698888389012002 0.466679786284541 no 1819 0.472141068336926 2559 891448
SGTC_1857 st056007 79.3 µM -0.070038173587414 0.466621358490574 no 1820 0.472081638047289 2573 619834
SGTC_47 0149-0135 24.25 µM -0.0702413390094983 0.466541870360853 no 1821 0.472000785894979 2507 5239155
SGTC_2645 abamectin 100 µM -0.0717520979800672 0.465950830524493 no 1822 0.471399597389617 2556 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3266 9136860 49.47 µM -0.0724289420358141 0.465686059553195 no 1823 0.471130276430041 2536 4871271 YPR165W RHO1
SGTC_788 1182-0090 188 µM -0.0726645300651218 0.465593904701571 no 1824 0.471036537405059 2745 5715185
SGTC_3062 9077494 49.47 µM -0.0729768845303217 0.465471724007202 no 1825 0.47091225596342 2565 16459633
SGTC_2484 5809818 12.04 µM -0.0736381178622596 0.465213086471478 no 1826 0.470649169896375 2577 2870548
SGTC_1859 st055998 20 µM -0.0737583448806549 0.465166061954707 no 1827 0.470601336334373 2537 676301
SGTC_190 3970-0790 3.722 µM -0.0740897444666317 0.465036443815866 no 1828 0.470469487781692 2516 2832352
SGTC_2793 7325131 81.82 µM -0.0748630340698501 0.464734006594223 no 1829 0.470161844263999 2607 4176441
SGTC_1896 st058441 89 µM -0.0754115088584312 0.46451950784908 no 1830 0.469943651270177 2565 688759
SGTC_1991 st073000 8.92 µM -0.0760266498370714 0.464278949411345 no 1831 0.469698948023897 2707 4301969 YIL048W NEO1
SGTC_411 enrofloxacin 100 µM -0.0774264245567213 0.463731599108612 no 1832 0.469142160059567 2591 71188 A bacterial gyrase inhibitor.
SGTC_3297 9117502 71.43 µM -0.0779664839330218 0.463520439375861 no 1833 0.468927356877881 2528 7453720
SGTC_508 roscovitine 141 µM -0.0801560126685356 0.462664453670965 no 1834 0.468056587173504 2548 160355 A CDKinase inhibitor.
SGTC_13 0199-0087 65 µM -0.0806269298044501 0.46248037333897 no 1835 0.467869324517375 2552 4589825
SGTC_2771 fluoxetine 41.05 µM -0.0810229047330865 0.462325593945907 no 1836 0.467711868522059 2637 3386 A selective serotonin reuptake inhibitor.
SGTC_3249 9135183 49.47 µM -0.0810559543834671 0.462312675696672 no 1837 0.467698726843358 2704 4902779
SGTC_2461 5755302 26.15 µM -0.0812214577848939 0.462247985317444 no 1838 0.467632917523474 2629 2788904
SGTC_375 3970-0961 9.27 µM -0.0816915485839761 0.462064246195104 no 1839 0.467445999575014 2600 2898222
SGTC_3103 9120822 49.47 µM -0.081848827527312 0.46200277414255 no 1840 0.467383463773187 2633 17141819
SGTC_628 1636-0253 16 µM -0.0819424910456788 0.461966166439092 no 1841 0.46734622253185 2598 4456143
SGTC_1479 0549-0158 134 µM -0.0820790883737912 0.461912778946707 no 1842 0.467291911033082 2583 5440202
SGTC_2075 5212009 200 µM -0.0821475903892958 0.461886005981248 no 1843 0.467264674659756 2582 780898
SGTC_1066 ketoconazole 628 nM -0.0824098948007122 0.461783489910156 no 1844 0.46716038395131 2628 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2307 7538926 6.34 µM -0.0841840021008591 0.461090185005152 no 1845 0.466455068753737 2602 96582
SGTC_1384 3089-0840 101 µM -0.0874093832283238 0.459830039920733 no 1846 0.465173055595075 2544 1069836
SGTC_2783 7738165 71.43 µM -0.0877826377881379 0.459684236477643 no 1847 0.465024718762537 2621 17201110
SGTC_229 benomyl 22.8748 µM -0.0880268309817613 0.459588850867841 no 1848 0.464927675437145 2637 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3132 9126706 49.47 µM -0.0883461712242782 0.45946411517796 no 1849 0.464800771530631 2768 850858
SGTC_1217 1183-1422 255 µM -0.0891444877162027 0.459152306760649 no 1850 0.464483541011611 2647 2849664
SGTC_2485 5633444 17.78 µM -0.0893484709424507 0.459072638513638 no 1851 0.464402486917182 2619 5724239
SGTC_3139 9095020 49.47 µM -0.089522572658087 0.459004642171183 no 1852 0.464333307608508 2535 25236292
SGTC_70 0141-0289 43.283 µM -0.0898917882433288 0.458860447049912 no 1853 0.464186603383167 2682 352408
SGTC_208 k072-0098 12.366 µM -0.090153154651519 0.458758375103973 no 1854 0.464082754922566 2588 5948901
SGTC_715 0868-0130 184 µM -0.0905571098269978 0.458600623032863 no 1855 0.463922256621844 2622 2876258
SGTC_2175 5807670 165.306 µM -0.0911762378016224 0.458358854611249 no 1856 0.463676277891493 2581 241186
SGTC_1134 3477-0009 42.5 µM -0.091989587155501 0.458041266495954 no 1857 0.463353156379257 2725 3973534
SGTC_471 1-acyl-paf 4 µM -0.0924750033183794 0.457851739040272 no 1858 0.463160325284368 2561 16759367
SGTC_2539 epi(13)torulosol 80 µM -0.0940896245261567 0.457221390310194 no 1859 0.462518981123061 2644 6708597
SGTC_3243 9134147 49.47 µM -0.0944516507191359 0.457080069860123 no 1860 0.462375193905588 2566 24282180
SGTC_175 3793-3120 23.7 µM -0.0946437608966575 0.457005079984518 no 1861 0.462298894825658 2597 5322297
SGTC_1843 st055809 45.5 µM -0.0965213811170189 0.456272235190637 no 1862 0.46155324676447 2690 16413835
SGTC_132 0417-1715 25.805 µM -0.096560406932799 0.45625700478385 no 1863 0.461537750100627 2593 6769098
SGTC_2130 NSC 7 2.4545 µM -0.0968306483702245 0.456151540796113 no 1864 0.461430442205876 2637 21448
SGTC_3317 9138495 8.753 µM -0.0975238128409557 0.455881041688568 no 1865 0.461155212224955 2579 17020139
SGTC_872 0588-0139 234 µM -0.0976570084607913 0.455829066036359 no 1866 0.461102327296318 2606 2047100
SGTC_3081 9117243 49.47 µM -0.0979918333596285 0.455698413860374 no 1867 0.460969389096309 2748 45595589
SGTC_945 3381-0768 11.3 µM -0.0992585444961011 0.455204173395637 no 1868 0.460466496258743 2595 1126236 YIL048W NEO1
SGTC_3260 9137109 49.47 µM -0.0993694160264405 0.455160917258172 no 1869 0.460422482513384 2541 17478346
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.101741125834188 0.454235731168239 no 1870 0.45948107890174 2642 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_499 genistein 192 µM -0.101934791093498 0.454160194708351 no 1871 0.459404217241817 2589 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_701 4424-0219 185 µM -0.102819705008967 0.453815067392463 no 1872 0.459053032907829 2634 2911779
SGTC_1142 3253-1408 9.78 µM -0.103327985199718 0.453616847615055 no 1873 0.458851332755639 2564 256655
SGTC_3285 9112818 20.8695 µM -0.104341041069295 0.453221809266391 no 1874 0.458449354789404 2583 17017947 YPR165W RHO1
SGTC_768 0384-0033 77.3 µM -0.105027732702989 0.452954062050553 no 1875 0.458176901449662 2594 3965305 YMR134W ERG29
SGTC_1827 berberine 7.24 µM -0.105265179191117 0.452861484509233 no 1876 0.458082696204532 2605 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1334 1486-0610 236 µM -0.105990203806982 0.452578821973802 no 1877 0.457795062316963 2714 3742339
SGTC_42 0133-0086 60.653 µM -0.106015551817231 0.452568940077274 no 1878 0.457785006579158 2596 162923 Model of phenazepam hydroxylation.
SGTC_1971 st069429 63.5 µM -0.106821001003014 0.452254951845958 no 1879 0.457465493205236 2641 1246522 YGL099W LSG1
SGTC_1007 4101-0031 70 µM -0.108114599703637 0.451750730871401 no 1880 0.456952393574838 2599 1146276
SGTC_1861 st057647 17.4 µM -0.109559260944401 0.451187720518794 no 1881 0.45637946057579 2797 688668
SGTC_260 nsc-65238 3.989 µM -0.111036424856349 0.450612144819708 no 1882 0.455793731225947 2628 3246252
SGTC_2797 7859098 81.82 µM -0.113191091299133 0.449772767357264 no 1883 0.454939529194973 2641 972681
SGTC_3312 9133330 71.43 µM -0.114299870153428 0.449340915900419 no 1884 0.454500042714063 2761 17617324
SGTC_2197 6588183 93.1375 µM -0.114489386339351 0.449267108396685 no 1885 0.454424929775037 2624 884136
SGTC_2999 9069765 71.4286 µM -0.114541708737379 0.449246731630508 no 1886 0.454404192576852 2674 2097066
SGTC_2375 9072683 200 µM -0.114721889726089 0.449176561829185 no 1887 0.454332781494 2597 16798029
SGTC_1386 3228-0095 33.8 µM -0.11499831178132 0.449068914934869 no 1888 0.454223230085226 2703 870181
SGTC_1175 0741-0056 27.6 µM -0.115311778261501 0.44894684638629 no 1889 0.454099001468219 2742 765927
SGTC_1925 st057770 10.1 µM -0.11553233157089 0.448860962515331 no 1890 0.45401159757985 2610 5989122
SGTC_2628 lathosterol 100 µM -0.115635007066501 0.448820981302586 no 1891 0.45397090868665 2723 6710616
SGTC_3060 1327-0027 12.5 µM -0.116422738211976 0.448514260910194 no 1892 0.453658757720284 2677 16000455 YPR107C YTH1
SGTC_1356 1502-0781 85.8 µM -0.116609236473523 0.448441648221481 no 1893 0.453584859008547 2593 567702
SGTC_1548 st061468 90.8 µM -0.116736305704261 0.448392175084645 no 1894 0.453534509580466 2668 390799
SGTC_3143 9086658 49.47 µM -0.116736826301854 0.448391972396818 no 1895 0.453534303302394 2697 25236626
SGTC_1012 4112-3522 18 µM -0.118303080645837 0.447782233091643 no 1896 0.452913758270259 2609 3112398
SGTC_2540 epiandrosterone 100 µM -0.11882327636646 0.44757974928375 no 1897 0.452707683726013 2639 441302 A steroid.
SGTC_2475 5812728 15.03 µM -0.119325704415501 0.447384194428586 no 1898 0.452508659902643 2600 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_290 2043-6722 48.1 µM -0.120136744154758 0.447068548855298 no 1899 0.452187412770182 2671 773758 YLR208W SEC13
SGTC_3121 9125696 49.47 µM -0.120167174191102 0.447056706552663 no 1900 0.452175360254862 2579 1235365
SGTC_182 3448-4371 550.524 µM -0.120221310688812 0.447035638643605 no 1901 0.452153918359587 2589 3491403
SGTC_734 2023-0417 80 µM -0.12060637164661 0.44688579157294 no 1902 0.452001410921709 2726 3935732
SGTC_2720 fluspirilene 36.88 µM -0.121674140158202 0.446470307528114 no 1903 0.45157854710294 2698 3396 An atypical antipsychotic.
SGTC_818 4072-2707 53.5 µM -0.121748486237633 0.446441380584927 no 1904 0.451549106181716 2621 882871
SGTC_1194 1488-0194 225 µM -0.122273854656962 0.446236975753308 no 1905 0.451341068784012 2601 1391452
SGTC_1255 0566-0045 221 µM -0.123017891447674 0.44594751818133 no 1906 0.451046465125514 2740 2788469
SGTC_2027 5150920 200 µM -0.124790475775446 0.445258034273533 no 1907 0.450344713839785 2704 786715
SGTC_2960 9079389 5.97 µM -0.126303772424543 0.444669536672144 no 1908 0.449745735106323 2701 16457355
SGTC_2118 5526350 200 µM -0.12632720656986 0.444660424451875 no 1909 0.449736460521674 2773 743594
SGTC_1656 st012921 11 µM -0.127009603602692 0.444395091495405 no 1910 0.449466398767148 2729 6732821
SGTC_2216 7189485 200 µM -0.127495611195336 0.444206134828457 no 1911 0.449274073297639 2692 731273
SGTC_2236 dapsone 200 µM -0.128882520769287 0.443666983062408 no 1912 0.448725303856165 2647 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1009 4106-0057 9.87 µM -0.12923771064053 0.443528922118994 no 1913 0.448584778815263 2619 2928005
SGTC_34 0469-0683 81.75 µM -0.131959803010473 0.442471084006085 no 1914 0.447508043093987 2722 3690923
SGTC_951 1171-0579 82.7 µM -0.133109321666743 0.442024489814779 no 1915 0.447053461563942 2609 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2058 5236698 133 µM -0.133259156323994 0.441966283658871 no 1916 0.446994213989217 2677 766665
SGTC_996 3970-0799 1.8 µM -0.133296472159145 0.441951787799472 no 1917 0.446979458756944 2714 6615648 YGL040C HEM2
SGTC_1245 0418-0076 17.2 µM -0.133456876396005 0.441889477410015 no 1918 0.44691603338901 2815 6790114
SGTC_3022 9087993 49.47 µM -0.133688636600685 0.441799450728297 no 1919 0.44682439558807 2647 17173644
SGTC_3313 9133968 57.047 µM -0.13640223365968 0.440745585512526 no 1920 0.44575165398904 2623 1494643
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.136609153524944 0.440665242268896 no 1921 0.445669870436284 2673 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_707 0865-0008 204 µM -0.136719303102452 0.44062247417484 no 1922 0.445626335569675 2666 723043
SGTC_2329 6138490 200 µM -0.137508299859266 0.440316148407657 no 1923 0.445314516362896 2924 720019
SGTC_2807 7945238 51.95 µM -0.137849023392758 0.440183874488104 no 1924 0.445179869549744 2756 17148797
SGTC_1680 diphenhydramine 100 µM -0.138957772750941 0.439753487854705 no 1925 0.444741758848497 2723 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1485 3909-9022 254 µM -0.140539243017873 0.439139727007559 no 1926 0.444116974352475 2664 714516
SGTC_602 3130-1533 38.1 µM -0.142476921988607 0.438387922877696 no 1927 0.443351653490176 2766 720941
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.142801448328532 0.438262030880395 no 1928 0.4432234966026 2703 688662
SGTC_2051 5263410 176 µM -0.144376162306176 0.437651248326394 no 1929 0.442601719653079 2645 227584
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.145052998590428 0.437388770147056 no 1930 0.442334513702499 2642 4620898
SGTC_2883 9059145 45.46 µM -0.146102700133383 0.436981748774216 no 1931 0.441920157446848 2640 16476510
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.146709841060158 0.436746360528242 no 1932 0.441680525309321 2804 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2298 7976326 193.81 µM -0.148434268659549 0.436077923177271 no 1933 0.441000028564981 2709 2235818
SGTC_1622 st003707 19.4 µM -0.148532574960911 0.436039822330907 no 1934 0.440961239982724 2775 10140899
SGTC_1415 3966-0071 78.1 µM -0.149821609018243 0.435540282866869 no 1935 0.44045268012604 2676 2893185
SGTC_2744 captopril 92.04 µM -0.150205297932612 0.43539161169824 no 1936 0.440301323086186 2722 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_194 1486-1323 56.904 µM -0.150323975633386 0.435345628500126 no 1937 0.440254509046202 2697 5178754
SGTC_3204 9114183 49.47 µM -0.15150774555434 0.434887009604824 no 1938 0.439787600650185 2649 17027248
SGTC_617 3770-0098 35 µM -0.152089681171581 0.434661586829847 no 1939 0.43955810138065 2690 5962639
SGTC_2201 6605497 169.863 µM -0.152152761394937 0.434637152894505 no 1940 0.439533225508679 2722 670741
SGTC_3196 9111891 49.47 µM -0.152311489435699 0.434575671168589 no 1941 0.439470631694508 2622 18891510
SGTC_1506 4226-2149 212 µM -0.15280848160325 0.434383176440998 no 1942 0.439274654470454 2773 991114
SGTC_1913 st060213 96.1 µM -0.153106618642137 0.434267709632319 no 1943 0.439157098248961 2787 688959
SGTC_1887 st057648 70.8 µM -0.153506433839676 0.434112872245315 no 1944 0.438999458485945 2833 688672
SGTC_1496 4469-0713 57.4 µM -0.15449427308235 0.433730352770136 no 1945 0.438610013213853 2691 746691
SGTC_1325 1431-0015 227 µM -0.155704618419042 0.433261757235687 no 1946 0.438132928301538 2685 1103340
SGTC_1921 5740136 50 µM -0.156228404431808 0.433058998051564 no 1947 0.4379264940623 2687 1774243
SGTC_3301 9125354 19.7965 µM -0.156450816032591 0.432972907160174 no 1948 0.43783884243731 2673 41905162
SGTC_2415 st077333 57.7 µM -0.156875902786306 0.432808373798133 no 1949 0.437671325740316 2768 2766255
SGTC_1760 st045453 10.4495 µM -0.157108834363499 0.432718220633047 no 1950 0.437579537617055 2723 3323419 YIL048W NEO1
SGTC_2272 7805186 180 µM -0.157923248340683 0.432403039757303 no 1951 0.437258639206055 2664 2956062 YPR165W RHO1
SGTC_2338 7999974 200 µM -0.158198349268534 0.432296584505326 no 1952 0.437150252234154 2792 315925
SGTC_1753 st043925 64 µM -0.160723357994482 0.431319717513959 no 1953 0.436155645791889 2754 670181
SGTC_1628 st004252 77.7 µM -0.162062850705764 0.430801669115744 no 1954 0.435628180126188 2840 692968
SGTC_2972 9093619 59.92 µM -0.16226905000159 0.430721932152314 no 1955 0.435546993078443 2713 25236256
SGTC_1611 st001856 99.4 µM -0.16313060753431 0.430388799714749 no 1956 0.435207800625085 2723 647478
SGTC_1462 k081-0014 26.5 µM -0.164330883346791 0.429924780073119 no 1957 0.434735335382777 2721 3270634
SGTC_3256 9138902 49.47 µM -0.164480446036751 0.429866966775534 no 1958 0.434676469452476 2675 17228773
SGTC_1348 1493-0373 93.8 µM -0.165769723062325 0.429368660604373 no 1959 0.434169086957251 2770 3010129
SGTC_2752 diclazuril 33.15 µM -0.168309569721983 0.428387338593432 no 1960 0.433169872855498 2841 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2289 7946404 165.07 µM -0.168577851305626 0.428283708226366 no 1961 0.433064351649627 2717 1246120 YPR165W RHO1
SGTC_1154 4088-0362 150 µM -0.168893589104065 0.42816175306344 no 1962 0.432940170956382 2700 6618304
SGTC_1425 4048-4433 7.33 µM -0.169657331194764 0.427866782595176 no 1963 0.432639816137005 2756 23734946
SGTC_2136 5328288 199.296 µM -0.170490621439428 0.427544997406285 no 1964 0.432312154698887 2743 262395
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.171188345282467 0.427275599896367 no 1965 0.432037835670378 2703 442882
SGTC_3128 9127691 49.47 µM -0.171659179465779 0.427093825698175 no 1966 0.431852739712046 2878 41316314
SGTC_3240 9133527 49.47 µM -0.171820295153145 0.427031627575866 no 1967 0.431789404790572 2734 17617455
SGTC_1031 k035-0009 16 µM -0.173046733841694 0.426558224972928 no 1968 0.431307346702713 2921 5180959
SGTC_2595 hexamethylquercetagetin 100 µM -0.17323220388156 0.426486643142105 no 1969 0.431234455628961 2805 386331
SGTC_2171 5739187 198.077 µM -0.175720690070377 0.425526451461434 no 1970 0.43025668994964 2675 2262761
SGTC_409 arachidonic acid 100 µM -0.176078366027901 0.425388477015296 no 1971 0.430116188392779 2715 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2072 5231554 129 µM -0.17649701253921 0.425226994623859 no 1972 0.429951747745144 2820 789545
SGTC_970 1315-0089 19.5 µM -0.176505599946815 0.42522368237796 no 1973 0.429948374814447 2725 6811083 YLR033W RSC58
SGTC_1778 st046819 58.9 µM -0.177338376890748 0.424902497391668 no 1974 0.42962130404241 2737 671715
SGTC_113 0099-0221 2.5 µM -0.177430909698915 0.424866812458631 no 1975 0.429584965023135 2792 89219
SGTC_3129 9127257 49.47 µM -0.177790598963583 0.424728105483327 no 1976 0.42944371533296 2750 837894
SGTC_1333 1482-0047 286 µM -0.179173654295254 0.424194844802499 no 1977 0.428900674891943 2729 3811116
SGTC_2102 5377816 72.7585 µM -0.18031874504396 0.423753440393879 no 1978 0.428451170225558 2906 1379702
SGTC_506 n9-isopropylolomoucine 153 µM -0.181518762949767 0.423290965563016 no 1979 0.427980203536261 2814 6610355
SGTC_1943 st076331 65.2 µM -0.18286810011816 0.422771070827154 no 1980 0.427450756605574 2794 24208415
SGTC_322 k048-0136 19.3 µM -0.182978646131586 0.422728483795665 no 1981 0.427407386827904 2815 6823282
SGTC_3049 9092223 49.47 µM -0.18323765880224 0.422628704623788 no 1982 0.427305773556742 2829 8623917
SGTC_3015 9080845 49.47 µM -0.183556185952542 0.422506005559801 no 1983 0.427180818770376 2846 5296973
SGTC_1600 coumarin 106 71.1 µM -0.18454310482511 0.422125884747415 no 1984 0.426793707515631 2886 100336 A hepatotoxic, DNA x-linker.
SGTC_360 0957-0399 1.01 µM -0.185571809367765 0.421729747006304 no 1985 0.426390281200376 2887 6752301 YPR165W RHO1
SGTC_431 k089-0097 107 µM -0.191652115434515 0.419389948268995 no 1986 0.424007358452375 2828 5499420
SGTC_3056 9094900 49.47 µM -0.193287165634321 0.418761237256132 no 1987 0.42336703857213 2780 25236784
SGTC_248 streptozotocin 5.23457 mM -0.195284476419082 0.417993511081149 no 1988 0.422585124569176 2839 5300 DNA alkylating agent.
SGTC_2704 st078022 71.1 µM -0.195497963149027 0.417911469495704 no 1989 0.422501566044848 2898 54697681
SGTC_2998 9066762 71.4286 µM -0.198391729873624 0.416799767249815 no 1990 0.421369293727898 2906 4945196
SGTC_568 1193-0097 7.48 µM -0.199420555799959 0.416404681599157 no 1991 0.420966891099192 2817 3646150
SGTC_2555 cholic acid 100 µM -0.201314897335665 0.415677445234572 no 1992 0.42022617731619 2931 6708657 Influences liver metabolism.
SGTC_2291 7917025 104.35 µM -0.20140825924337 0.41564161110948 no 1993 0.420189678798612 2767 2964612
SGTC_1613 st002381 52.1 µM -0.202079229603619 0.415384100224283 no 1994 0.419927392632943 2763 551167
SGTC_2876 9059903 25.97 µM -0.202372856741217 0.415271420852697 no 1995 0.419812623278595 2736 6916095
SGTC_2045 5106652 78.05 µM -0.202509848193666 0.415218852785973 no 1996 0.419759080081607 2901 673349
SGTC_2978 9011784 42.97 µM -0.203592578525716 0.414803427488509 no 1997 0.419335946579336 2903 2994934
SGTC_2473 5854593 8.94 µM -0.204740723430895 0.414363007797841 no 1998 0.418887350807674 2717 2872951
SGTC_918 glabranin 770.725 nM -0.205549778828126 0.414052724897258 no 1999 0.418571305195803 2820 124049 Also referred to as licorice root.
SGTC_624 k048-0052 28 µM -0.206454808624776 0.413705698181044 no 2000 0.418217830878801 2815 6835531
SGTC_2888 9058547 12.99 µM -0.209438101950116 0.412562255869232 no 2001 0.417053125593655 2787 16476514
SGTC_621 3584-0052 32.1 µM -0.209966187700642 0.412359927147607 no 2002 0.416847031539588 2812 2273927
SGTC_1691 st019933 84.6 µM -0.2103475424633 0.412213830844438 no 2003 0.416698215845999 2765 6176082
SGTC_2436 5633522 8.09 µM -0.211074904451793 0.411935213556775 no 2004 0.41641441120706 2902 5724242
SGTC_427 1354-0053 47.3 µM -0.21119583910742 0.411888893624352 no 2005 0.4163672287214 3014 6813657
SGTC_2819 7996655 46.38 µM -0.211833340010762 0.411644740757721 no 2006 0.416118528576396 2862 6456960
SGTC_54 0159-0055 9 µM -0.211978419603422 0.4115891823195 no 2007 0.416061935201801 3017 3319099
SGTC_2722 naftopidil 47.16 µM -0.212058816585666 0.411558394943033 no 2008 0.416030574293444 2802 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_35 0133-0054 64.071 µM -0.216023106901219 0.410040980982963 no 2009 0.414484868041126 2824 99677
SGTC_1263 0774-1208 64.8 µM -0.217458383488967 0.409491929943362 no 2010 0.413925568062632 2921 906585
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.218025898590941 0.409274881483582 no 2011 0.413704466314484 2888 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2903 5923464 63.88 µM -0.219568426123287 0.40868507625537 no 2012 0.413103641814794 2885 2876576
SGTC_934 2950-0684 338 µM -0.219577520867105 0.408681599374959 no 2013 0.413100099954961 3007 1121253
SGTC_1357 1503-1303 39.5 µM -0.219865478966856 0.408571517982227 no 2014 0.412987961122711 2811 292895
SGTC_3221 9128209 49.47 µM -0.219927601445878 0.408547770580387 no 2015 0.41296376984539 2833 16460723
SGTC_2457 5731572 11.68 µM -0.220535071798467 0.408315572145067 no 2016 0.412727230655247 2950 2865357
SGTC_2423 st077119 87.2 µM -0.220705413639457 0.408250466744185 no 2017 0.412660907965489 2737 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2893 9048488 25.97 µM -0.221784294056002 0.407838172793908 no 2018 0.41224090326239 2827 6467338
SGTC_774 k060-0086 136 µM -0.222920447621288 0.407404102234385 no 2019 0.411798710943473 2785 5911235
SGTC_403 arphamenine a 50 µM -0.225024202599893 0.40660065741198 no 2020 0.410980223052551 2800 5487158 An arginine aminopeptidase inhibitor.
SGTC_1035 k081-0041 55.2 µM -0.225972087318465 0.406238779096527 no 2021 0.410611564967925 2841 731709
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.227326975701639 0.405721656226228 no 2022 0.410084749282127 2782 6708784 An antioxidant flavonoid
SGTC_3163 9099914 49.47 µM -0.227365889598675 0.40570680630953 no 2023 0.410069620943676 2908 16268368
SGTC_2979 9012552 45.46 µM -0.22955536630837 0.404871500193625 no 2024 0.409218646585148 2914 17100905
SGTC_1707 st032323 6.317 µM -0.230046775891023 0.404684082180451 no 2025 0.409027711184995 2829 3132057 YMR211W DML1
SGTC_997 3996-0078 137 µM -0.230628968420403 0.404462068886742 no 2026 0.408801530338441 2882 735687
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.230920323882005 0.404350974941634 no 2027 0.408688350614335 2867 756377
SGTC_3280 9140961 49.47 µM -0.23173527205261 0.404040275884221 no 2028 0.408371816924019 2786 4901226
SGTC_264 promethazine 12.5 mM -0.23193515451978 0.403964079912768 no 2029 0.408294189775984 2841 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1557 sumaresinolic acid 42.3 µM -0.234015098639179 0.403171413900539 no 2030 0.407486628530372 2819 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3261 9137475 49.47 µM -0.234288020274715 0.403067433003073 no 2031 0.407380692789497 2789 17027690
SGTC_2822 7994718 71.43 µM -0.234986385448718 0.402801392843284 no 2032 0.407109650115532 2754 1018011
SGTC_1940 st075990 51.1 µM -0.235979539308063 0.402423131324758 no 2033 0.406724273564402 3068 1084979
SGTC_383 2324-0395 7.37 µM -0.236509829690612 0.402221197540753 no 2034 0.406518540314073 2957 3146421
SGTC_99 0109-0120 622.8 µM -0.237621776143293 0.401797854776024 no 2035 0.406087229645024 2944 759414
SGTC_252 miconazole 1.30953 nM -0.237767059314994 0.401742550737789 no 2036 0.406030884454087 2917 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3295 9122362 53.5725 µM -0.237981947342521 0.401660754261374 no 2037 0.405947547971829 2933 4730473
SGTC_1951 sophoraflavanone G 9.2 µM -0.241469602833318 0.400333793585449 no 2038 0.404595586477341 2815 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_898 1000-0849 28.3 µM -0.242261699358624 0.400032581459768 no 2039 0.404288694688727 2865 6751807
SGTC_1556 plumbagin 1.48 µM -0.242781899210825 0.399834796362946 no 2040 0.40408717922661 2820 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2342 7990637 118.86 µM -0.243695319053254 0.399487567361432 no 2041 0.403733399475387 2952 2033102 YER133W GLC7
SGTC_2686 alizarin 95.37 µM -0.244352456942186 0.39923781097264 no 2042 0.403478929846114 2903 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3028 9087778 49.47 µM -0.244662567712266 0.399119962436221 no 2043 0.403358856946186 2831 17217395
SGTC_323 4013-0906 34.3 µM -0.244811179265647 0.399063490215951 no 2044 0.403301318734695 2927 2910086
SGTC_2344 7990960 76.95 µM -0.244819488172614 0.399060332903156 no 2045 0.403298101821512 2874 140813
SGTC_2417 cerulenin 830 nM -0.245217239335434 0.398909198629212 no 2046 0.403144114379761 2879 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_385 1494-0393 12.4 µM -0.246112258085715 0.39856917208548 no 2047 0.402797667147515 2879 3090647
SGTC_3190 9110366 49.47 µM -0.246208355391355 0.398532668333372 no 2048 0.402760473971772 2931 17123768
SGTC_1241 0364-0022 50.8 µM -0.246366423671701 0.398472626069994 no 2049 0.402699297674167 2894 4563895
SGTC_2258 7960471 200 µM -0.246861364281293 0.398284638344738 no 2050 0.402507758945699 2909 2974708
SGTC_1165 k072-0275 30.3 µM -0.247312231883976 0.398113410917954 no 2051 0.402333296545208 2904 6153523 YGL055W OLE1
SGTC_3116 9124943 49.47 µM -0.24832700107755 0.397728100604675 no 2052 0.401940704658734 2868 41905195 YPL160W CDC60
SGTC_1466 k213-0079 57.5 µM -0.249621118143135 0.39723686598522 no 2053 0.401440182786222 2840 3657981
SGTC_77 0828-0286 12.516 µM -0.251178145830723 0.396646049023742 no 2054 0.400838190074421 2808 745345
SGTC_1908 st060353 56.5 µM -0.252289424131143 0.396224517449728 no 2055 0.400408681062718 3058 4227716
SGTC_478 N-arachidonylglycine 10 µM -0.25278230421463 0.396037596316254 no 2056 0.400218221446819 2873 5283389
SGTC_870 0573-2213 57.6 µM -0.254008504738498 0.395572672602302 no 2057 0.399744493855221 2839 3916321
SGTC_882 0843-0131 351 µM -0.254447890398388 0.39540611214452 no 2058 0.399574778441931 2839 5425421
SGTC_936 3005-4620 401 µM -0.255867307242774 0.394868176298656 no 2059 0.399026649759425 3063 777207
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.257108902539605 0.394397796155127 no 2060 0.39854735264093 2866 368090
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.257285619124962 0.394330859325004 no 2061 0.398479146576191 2866 2724278 An inhibitor of dopamine biosynthesis.
SGTC_693 4161-2696 114 µM -0.257581755597723 0.394218695544483 no 2062 0.398364855806048 2963 805759
SGTC_191 3914-0123 66.505 µM -0.258554784044937 0.393850215956318 no 2063 0.397989387098469 2850 3144412
SGTC_558 k064-0027 21.3 µM -0.259540584324073 0.393476996651756 no 2064 0.39760908636062 2968 5088526
SGTC_300 r073-0011 5.04 µM -0.259750107501716 0.393397684769316 no 2065 0.397528269308961 2929 2735780
SGTC_3236 9132701 49.47 µM -0.263300771319886 0.392054308952213 no 2066 0.396159382615816 2927 24282524
SGTC_1049 3226-0134 66 µM -0.263584962089392 0.391946842163528 no 2067 0.396049873682588 2870 5702385
SGTC_646 4092-0839 27.3 µM -0.263592560006262 0.391943969123048 no 2068 0.39604694604427 3015 877796
SGTC_1148 3909-7663 27.7 µM -0.263959092716552 0.391805377172122 no 2069 0.395905720193686 3002 4084526
SGTC_2529 gangaleoidin 93.61 µM -0.264704079054664 0.391523728105342 no 2070 0.395618717462586 2862 4565183
SGTC_2603 homopterocarpin 100 µM -0.265105026527665 0.391372169680338 no 2071 0.39546427761597 3006 101795 A weak amylase inhibitor.
SGTC_3041 9091929 49.47 µM -0.266184945510035 0.390964041632012 no 2072 0.395048388326686 3055 25236887
SGTC_1748 st037455 53.6035 µM -0.266679708973241 0.390777098377552 no 2073 0.394857889095065 3052 580690
SGTC_2851 9015922 71.43 µM -0.267271357483332 0.390553580860266 no 2074 0.3946301191262 3068 2996893
SGTC_1317 1273-0028 910 nM -0.26730328555651 0.390541519855396 no 2075 0.394617828635245 2890 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_272 doxorubicin 8.13 µM -0.267741294161936 0.39037607033891 no 2076 0.394449230846707 2856 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1144 3486-0183 12.5 µM -0.271149021818473 0.38908954544379 no 2077 0.393138209661447 2891 6744069
SGTC_3046 9092212 49.47 µM -0.271324995343437 0.389023142748957 no 2078 0.393070541873183 2882 25236637
SGTC_2985 9022375 71.43 µM -0.271409430799604 0.38899128261918 no 2079 0.393038074723651 3082 4939335
SGTC_474 dl-dihydrosphingosine 5 µM -0.272421957394988 0.388609282975161 no 2080 0.392648795680682 3028 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2037 5169046 200 µM -0.272546257157061 0.388562395360012 no 2081 0.392601014409033 2995 5718022
SGTC_3308 9128332 17.569 µM -0.273066007409321 0.388366355864466 no 2082 0.392401238102041 3048 17332805 YDL196W YDL196W
SGTC_2605 digitonin 300 nM -0.273665487238318 0.388140279267806 no 2083 0.392170851364465 3007 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2531 methyl deoxycholate 70.07 µM -0.27636360550456 0.387123231674258 no 2084 0.39113440357708 2881 16667744 Haematoxylin.
SGTC_3347 9188721 44.724 µM -0.277253487391441 0.386787962849083 no 2085 0.390792735854566 2962 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3134 9127454 49.47 µM -0.277561446620701 0.386671956855269 no 2086 0.390674515367729 2973 24262820
SGTC_2043 5101342 149 µM -0.278509623278408 0.386314849253395 no 2087 0.390310589427666 2926 678451
SGTC_3075 9116269 49.47 µM -0.27884552687286 0.386188362440226 no 2088 0.390181687087515 3106 17015205 YNL244C SUI1
SGTC_3095 9117207 49.47 µM -0.279135441528832 0.386079202802787 no 2089 0.390070442617916 3011 17015229
SGTC_2655 perillic acid 100 µM -0.279970444140075 0.385764855241602 no 2090 0.389750090304952 2907 5702197 An apoptosis inducer.
SGTC_1957 st077035 62.4 µM -0.282130840677225 0.384951894488718 no 2091 0.38892159296869 3007 705593
SGTC_831 k061-1017 217 µM -0.282431036306383 0.384838970301375 no 2092 0.388806509859202 2970 1240153
SGTC_473 2-arachidonoylglycerol 10 µM -0.28408939045454 0.38421532571729 no 2093 0.388170938673478 2852 5282280 An endocannabinoid.
SGTC_2636 apigenin dimethyl ether 100 µM -0.284589954078189 0.384027141374213 no 2094 0.387979154308187 3050 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1590 st077108 57.8 µM -0.286111928027906 0.383455131134256 no 2095 0.387396198011459 3005 5489485
SGTC_990 3985-0011 41.3 µM -0.286940377209572 0.383143878041158 no 2096 0.387078986645997 2954 5399565 YGL099W LSG1
SGTC_1423 4048-0112 5.59 µM -0.287852877601794 0.382801133722838 no 2097 0.386729679524494 2995 X1423
SGTC_2762 leflunomide 42.06 µM -0.288292324410258 0.382636105803029 no 2098 0.386561491048731 2913 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3013 9080133 71.4286 µM -0.291949432736969 0.3812635606302 no 2099 0.385162643588595 3132 17050193
SGTC_3113 9123498 49.47 µM -0.294053679777702 0.380474493197707 no 2100 0.384358442519447 2928 8897275
SGTC_1098 clofazimine 15.1 µM -0.29432178384441 0.380373993015645 no 2101 0.384256014175871 3033 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3165 9101544 49.47 µM -0.294504158632677 0.38030563350649 no 2102 0.384186343060896 3028 5002184
SGTC_2496 diffractaic acid 79.83 µM -0.295134279474601 0.380069474207536 no 2103 0.383945652078671 3176 94870 An apoptosis inducer which activates caspases.
SGTC_2576 guaiol 23.12 µM -0.29692904139168 0.379397071200846 no 2104 0.38326034184764 3040 227829
SGTC_2726 cimetidine 79.27 µM -0.297405489950477 0.379218632118661 no 2105 0.383078476415966 2929 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_444 curcumin 90.4 µM -0.29814105937318 0.378943197863298 no 2106 0.382797752436042 3048 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1418 3966-3099 2.4 µM -0.300893480485195 0.377913099011818 no 2107 0.381747860951598 3028 740335
SGTC_589 1227-0070 34.1 µM -0.302134245456319 0.377449023570191 no 2108 0.38127486374428 3051 2841384
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.302289352506049 0.377391022290656 no 2109 0.38121574718937 2956 4174840
SGTC_2779 methotrexate 400 µM -0.302463161067448 0.377326030987299 no 2110 0.38114950614761 3029 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1077 5-fluorocytosine 377 nM -0.302900925772632 0.377162355376897 no 2111 0.380982682906887 3013 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1196 1588-0294 184 µM -0.304807262469569 0.376449853803312 no 2112 0.380256474965993 2989 6144269
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.305758363789047 0.376094532748175 no 2113 0.379894316006007 3048 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1702 st027038 51 µM -0.305968889076077 0.376015896986161 no 2114 0.37981416672083 2994 5521182
SGTC_3034 9090421 49.47 µM -0.306567949961202 0.375792162924252 no 2115 0.379586125930385 2949 17173761
SGTC_2182 6325192 200 µM -0.307865706554905 0.375307627004965 no 2116 0.379092260698988 2961 736248
SGTC_2247 cerulenin 830 nM -0.308271525324018 0.37515614911234 no 2117 0.378937865583296 3170 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3172 9105863 49.47 µM -0.30837210458899 0.375118609381529 no 2118 0.378899602849352 2996 2348785
SGTC_1671 st016596 74.5 µM -0.309123437677382 0.374838222804376 no 2119 0.378613815519484 2993 2829167
SGTC_1973 st070275 50.2 µM -0.310347251926702 0.37438165480888 no 2120 0.378148450952731 2973 17118334
SGTC_1534 6-azauridine 81.6 µM -0.310660354092783 0.374264874146776 no 2121 0.378029419864605 2944 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_652 0437-0092 114 µM -0.311888901391288 0.373806762823559 no 2122 0.377562478750697 2971 3091274
SGTC_592 k241-0073 46.5 µM -0.312202244526169 0.373689949228187 no 2123 0.377443413209132 3079 4230158
SGTC_881 0833-0569 170 µM -0.312243589216868 0.37367453688943 no 2124 0.377427703736136 2969 5418700
SGTC_930 2810-3379 265 µM -0.313068651399681 0.373367015175032 no 2125 0.377114252665608 3165 1015764
SGTC_2222 6885208 172.143 µM -0.31389620623785 0.373058645382643 no 2126 0.376799935926984 2998 609514
SGTC_1966 st070145 16.1 µM -0.314094091535271 0.372984919892784 no 2127 0.376724788449784 2896 3748532
SGTC_969 1313-0238 134 µM -0.314471208291876 0.372844431594235 no 2128 0.376581590275053 2966 5212874
SGTC_658 3253-0951 102 µM -0.314629037096266 0.372785640232558 no 2129 0.376521664812144 3005 1184878
SGTC_2706 st078239 82.5 µM -0.314860132209026 0.372699562455781 no 2130 0.376433926491332 2962 15434492
SGTC_1079 idarubicin 2.36 µM -0.31500833461097 0.372644363710746 no 2131 0.376377662845711 3088 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_355 1311-2252 105 µM -0.315672902987259 0.372396873983213 no 2132 0.376125398035737 2979 5338538
SGTC_2665 lovastatin 100 µM -0.3162581402492 0.372178971319128 no 2133 0.375903290493404 2985 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1351 1496-0003 46.5 µM -0.317060157604385 0.371880420930518 no 2134 0.375598977978811 3092 3891978
SGTC_1201 1889-3372 45.9 µM -0.318841619486887 0.371217548796078 no 2135 0.374923308139946 2981 5392199
SGTC_1559 coumarin 343 70.1 µM -0.320434985715808 0.370624989438519 no 2136 0.374319303891389 3125 108770 A hepatotoxic, DNA x-linker.
SGTC_1956 st077085 54 µM -0.321272634036962 0.370313598083046 no 2137 0.374001896465182 2996 24208685
SGTC_940 3232-1287 54.8 µM -0.321435473127547 0.37025307336616 no 2138 0.373940202273352 3007 1585493 YIL048W NEO1
SGTC_2090 5301565 104.445 µM -0.3223130411696 0.369926950530334 no 2139 0.373607777226241 2985 2056344
SGTC_1455 4262-0120 131 µM -0.322457045821044 0.369873444283374 no 2140 0.373553236864574 3139 1529587
SGTC_2490 carminic acid 95.39 µM -0.323334758626642 0.369547376553928 no 2141 0.373220866469237 2944 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2695 st077686 51.995 µM -0.32356732577335 0.369460994252132 no 2142 0.373132814239091 3028 2876092
SGTC_3274 9138298 49.47 µM -0.324564872849512 0.369090550624739 no 2143 0.372755208228084 2937 17015756
SGTC_695 3505-6186 243 µM -0.324988386378268 0.368933313693931 no 2144 0.372594930679794 3094 1819379
SGTC_173 1273-0061 2.693 µM -0.325505816485924 0.368741238332538 no 2145 0.372399140597483 3079 2847414 YPL266W DIM1
SGTC_577 r071-0003 38.6 µM -0.325764180272943 0.368645343314218 no 2146 0.372301390811718 2981 4568517 YMR134W ERG29
SGTC_1248 0469-0687 58.6 µM -0.327222650323484 0.36810416709488 no 2147 0.371749745291119 3083 4017482
SGTC_1643 st009866 20.2 µM -0.327357320244736 0.368054209992324 no 2148 0.371698821569652 3076 3156273 YOR207C RET1
SGTC_1819 st053448 58.6 µM -0.328613729156177 0.367588240645046 no 2149 0.371223834768611 2989 2857616
SGTC_2675 theaflavin digallate 100 µM -0.329072063510735 0.367418304840692 no 2150 0.3710506097243 3029 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_696 1560-0013 611 µM -0.329537305047562 0.367245834623514 no 2151 0.370874800865388 3186 1650269
SGTC_2792 7535235 81.82 µM -0.329825412314217 0.36713904347768 no 2152 0.370765942304939 3060 1281891
SGTC_2305 7443522 69.23 µM -0.330691515206302 0.366818071772669 no 2153 0.370438755974313 2973 5415886
SGTC_2441 5730946 39.09 µM -0.331734215052933 0.366431777978039 no 2154 0.37004498121059 3122 1774275
SGTC_123 0083-0120 66.675 µM -0.332339952193395 0.366207429859355 no 2155 0.369816287575207 3004 16001701
SGTC_3340 9146634 11.102 µM -0.333734334831534 0.365691163367151 no 2156 0.369290019059677 3088 4907387
SGTC_640 3381-0960 37.1 µM -0.334303340079737 0.365480560483848 no 2157 0.369075335136739 3062 1745025
SGTC_3279 9140807 49.47 µM -0.334529371567343 0.365396911902402 no 2158 0.368990065483114 3002 45595718
SGTC_2091 4-phenylthiadiazole 200 µM -0.334843488963241 0.365280675568314 no 2159 0.368871576409781 2992 270010
SGTC_1409 3909-8004 61.9 µM -0.336716121321203 0.364587981817883 no 2160 0.368165454643267 3039 2119279
SGTC_3195 9113082 49.47 µM -0.337288949570567 0.364376178651909 no 2161 0.367949544561546 3097 17018038
SGTC_834 0312-0008 75.7 µM -0.34046596580699 0.363202230586745 no 2162 0.366752824425513 2999 6385573 YIL048W NEO1
SGTC_1978 st071761 42 µM -0.341705138259463 0.36274468798106 no 2163 0.36628640243093 3015 5147680
SGTC_708 3448-5400 146 µM -0.342042595461866 0.362620121763139 no 2164 0.366159418406487 3109 3462195
SGTC_2296 7971656 126.45 µM -0.343256587602025 0.362172118860218 no 2165 0.365702718489431 3073 666570
SGTC_2160 5660466 132.927 µM -0.345695378588311 0.361272695976902 no 2166 0.364785828868749 3099 2859134
SGTC_1046 2001-0062 216 µM -0.345714352592459 0.361265701387062 no 2167 0.364778698411381 2989 739778
SGTC_1359 1582-0056 520 nM -0.348241051676592 0.360334672456305 no 2168 0.36382958007193 3112 3661189
SGTC_1337 1486-1011 40.3 µM -0.348348760149349 0.360295002780991 no 2169 0.363789139438937 3061 X1337
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.348539824479399 0.360224636345031 no 2170 0.363717405431931 3123 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1343 1487-0095 224 µM -0.349539111958355 0.359856689330181 no 2171 0.363342306556496 3160 4560101 YGL055W OLE1
SGTC_1860 st056228 74.6 µM -0.350424832781385 0.359530667147881 no 2172 0.363009946280101 3134 688679
SGTC_3066 9117245 49.47 µM -0.353015470272442 0.358577675055434 no 2173 0.362038421331286 3059 17176980
SGTC_1461 k072-0203 53.8 µM -0.354751780617433 0.357939447918832 no 2174 0.361387777621149 3080 5418714
SGTC_1690 st023502 41.2 µM -0.355085031561761 0.357816997995004 no 2175 0.361262945011383 3126 24207482
SGTC_2642 cholecalciferol 100 µM -0.355616005275631 0.357621926929155 no 2176 0.36106407786851 3125 9821465 A vitamin D precursor, similar to steriods.
SGTC_973 1325-0077 65.9 µM -0.357620457447445 0.35688585949626 no 2177 0.360313683336726 3075 2835149
SGTC_820 1582-0060 59.9 µM -0.358128624811625 0.356699336676898 no 2178 0.360123529157219 3053 3848840
SGTC_2581 avocatin a 64 µM -0.35859711688977 0.356527407021338 no 2179 0.359948251964745 3057 6710728 A skin care supplement.
SGTC_3246 9135460 32.98 µM -0.359706799120883 0.35612028642762 no 2180 0.359533203484747 3111 41446951
SGTC_1324 1418-0026 34.4 µM -0.360365524827252 0.355878690445311 no 2181 0.359286902167589 3139 1372513
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.361597923266976 0.35542684820369 no 2182 0.358826258398146 3085 688761
SGTC_3332 9141069 11.198 µM -0.361874278034902 0.355325554320744 no 2183 0.358722991137405 3010 17332883
SGTC_89 0302-0250 142.109 µM -0.362485770614388 0.355101456807108 no 2184 0.358494527493882 3052 4203518 YLR208W SEC13
SGTC_548 1436-0017 110 µM -0.363302617811801 0.354802179887939 no 2185 0.358189419011578 3186 9677137
SGTC_1840 st055363 71 µM -0.364868409780584 0.354228754754241 no 2186 0.357604818181362 3085 676033
SGTC_3114 9122766 49.47 µM -0.366951853599702 0.353466267283836 no 2187 0.356827465861476 3098 17176985
SGTC_73 0327-0325 16.231 µM -0.368232789597909 0.352997768786776 no 2188 0.356349831412656 3155 53298
SGTC_536 3852-0578 10.6 µM -0.368828395868263 0.35278000340898 no 2189 0.3561278188689 3197 2869208
SGTC_329 k048-0121 21.3 µM -0.370685689836821 0.352101250112838 no 2190 0.355435825025256 3126 6832902
SGTC_2337 9009472 200 µM -0.370807185519941 0.352056865561695 no 2191 0.355390574524432 3260 5742383
SGTC_3039 9090270 49.47 µM -0.371160515848408 0.351927799113944 no 2192 0.355258989877474 3208 17173750
SGTC_821 1114-0266 29.2 µM -0.371335552429539 0.351863867105769 no 2193 0.355193810449232 3134 3123235
SGTC_1478 0453-0656 35.7 µM -0.372866989888348 0.351304689275559 no 2194 0.354623720705554 3139 5258496
SGTC_673 1082-0474 110 µM -0.3738093137471 0.350960775858372 no 2195 0.354273094834086 3092 3098046
SGTC_519 k048-0011 62.8 µM -0.374626860760449 0.350662500250859 no 2196 0.35396899675917 3147 6836379
SGTC_1998 st075797 76.8 µM -0.374976574214274 0.350534938137457 no 2197 0.353838944363287 3183 24208315
SGTC_386 1509-0011 3.07 µM -0.375207265405818 0.350450800024578 no 2198 0.353753163626034 3062 3107280
SGTC_1625 st003711 30.1 µM -0.376040864107613 0.350146829567071 no 2199 0.353443258304456 3265 24207034 YER133W GLC7
SGTC_954 1189-0853 2.85 µM -0.376270819718579 0.350062993497049 no 2200 0.353357785251967 3086 2828194
SGTC_3145 9085516 49.47 µM -0.377241073998911 0.349709343532828 no 2201 0.352997229320926 3153 25236195
SGTC_2875 9039966 71.43 µM -0.378379402717274 0.349294597986269 no 2202 0.352574383525997 3127 6463691
SGTC_764 1951-2361 146 µM -0.379033695778006 0.349056290291655 no 2203 0.352331420935607 3077 5438930
SGTC_902 1120-0002 2.07 µM -0.379737933196162 0.348799858284 no 2204 0.352069979528972 3067 3280475
SGTC_2708 st078559 56 µM -0.380871988821616 0.348387062941307 no 2205 0.351649119197343 3180 17250902
SGTC_908 3448-7491 47.7 µM -0.382445487390006 0.347814608111961 no 2206 0.351065477951413 3052 1203031
SGTC_1554 st069299 38.7 µM -0.382763631086417 0.347698906290532 no 2207 0.3509475148949 3157 24207999
SGTC_285 1486-1325 46 µM -0.383157936996005 0.347555525641931 no 2208 0.350801331931879 3185 22310230
SGTC_556 4058-0063 51.5 µM -0.383240849839013 0.347525378989055 no 2209 0.350770596056519 3127 6615692
SGTC_2355 9061122 103.12 µM -0.384438059481222 0.347090187734689 no 2210 0.350326898175659 3173 5302957
SGTC_464 bw-b 70c 158 µM -0.384950000973688 0.346904156124279 no 2211 0.350137229819136 3186 5353454
SGTC_1246 0422-0085 105 µM -0.384951186761638 0.346903725270116 no 2212 0.35013679054189 3229 264295
SGTC_2617 dihydrotanshinone i 20.83 µM -0.385885842574315 0.346564181180614 no 2213 0.349790608050833 3070 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2358 9037157 4 µM -0.386889453690502 0.346199724044094 no 2214 0.34941902454669 3173 2388925
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.386946280164083 0.346179092006697 no 2215 0.349397989055873 3110 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2278 7948257 134.34 µM -0.387340246767207 0.346036066764946 no 2216 0.349252166917297 3204 1247028
SGTC_2466 5983409 37.09 µM -0.387550952219494 0.345959581480659 no 2217 0.34917418588539 3108 2879657
SGTC_1895 st058434 18.3 µM -0.387760732778263 0.345883438172497 no 2218 0.349096553477671 3227 5393175
SGTC_2774 tamoxifen 10.92 µM -0.38789608340215 0.345834313742364 no 2219 0.349046468322783 3124 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1377 2944-0135 198 µM -0.38800836308099 0.345793564697129 no 2220 0.349004922337465 3131 1894137
SGTC_2014 4013930 200 µM -0.388299662376422 0.345687853378526 no 2221 0.348897143541603 3190 64556
SGTC_2204 7233102 200 µM -0.388777670468372 0.345514412275613 no 2222 0.348720310154727 3083 2172480
SGTC_3166 9102297 49.47 µM -0.388858755568092 0.345484994464292 no 2223 0.348690316948942 3127 25237072
SGTC_634 1611-4317 11.2 µM -0.388891328400785 0.345473177248237 no 2224 0.348678268593707 3210 2843522
SGTC_1291 0993-0025 5.79 µM -0.389946318914882 0.345090514908576 no 2225 0.348288121055049 3201 4353356
SGTC_334 1502-1024 68.5 µM -0.390357322578591 0.34494147998766 no 2226 0.348136170622228 3186 3296216
SGTC_2002 4023503 131 µM -0.390523280705778 0.344881308370497 no 2227 0.348074821849783 3265 4736863 YCR052W RSC6
SGTC_2746 daunorubicin 9.88 µM -0.390761468750501 0.344794955130134 no 2228 0.347986779213716 3126 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.390889709395817 0.344748465820242 no 2229 0.347939380377022 3092 5106787 A p450 inhibitor.
SGTC_2747 doxorubicin 7.63 µM -0.391631862945219 0.344479469202851 no 2230 0.347665120775784 3103 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2945 9067681 61.76 µM -0.39173088044796 0.344443585842973 no 2231 0.347628535313804 3150 16456930
SGTC_14 0354-0009 295 µM -0.392919482181267 0.344012952924424 no 2232 0.347189475886225 3098 1713507
SGTC_337 1315-0038 354 µM -0.393833282485603 0.343682018617149 no 2233 0.346852065143117 3114 1626437
SGTC_435 c-PAF 6.7 µM -0.394239976963353 0.343534772027166 no 2234 0.346701936692841 3220 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2212 7123476 200 µM -0.395666832514623 0.343018356842074 no 2235 0.346175413339647 3120 1085715
SGTC_2224 6650123 117.647 µM -0.397076798431466 0.342508342322476 no 2236 0.345655414333898 3143 2908370
SGTC_1378 2093-0007 380 nM -0.397623422590766 0.342310693945729 no 2237 0.345453896199792 3203 3618014
SGTC_2616 abietic acid 100 µM -0.398728320838686 0.341911316717965 no 2238 0.345046698857688 3267 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1735 st034310 56.75 µM -0.399570465781291 0.3416070331963 no 2239 0.34473645660172 3270 871153
SGTC_2487 5918373 44.05 µM -0.399984015910247 0.341457647066641 no 2240 0.34458414487147 3267 2876279
SGTC_886 0866-0150 153 µM -0.401112868703049 0.341049999640844 no 2241 0.344168513366099 3266 271463
SGTC_441 propafenone 146 µM -0.40164275470688 0.34085871296971 no 2242 0.343973479877658 3075 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_328 k915-0120 63.5 µM -0.402470530973224 0.340559971021043 no 2243 0.343668885927406 3213 6624543
SGTC_3228 9131799 49.47 µM -0.403387231563792 0.340229253245224 no 2244 0.343331689205359 3161 17015818
SGTC_1424 4048-1941 275 µM -0.403986755178634 0.340013029738925 no 2245 0.3431112294364 3247 X1424
SGTC_2733 amorolfine 100 µM -0.406424772229723 0.33913427992276 no 2246 0.342215260531315 3179 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2946 9065502 71.43 µM -0.406907317935922 0.338960456446085 no 2247 0.342038030506027 3133 16489101
SGTC_3138 9097216 49.47 µM -0.407835917617432 0.33862605109377 no 2248 0.341697071125346 3181 25237486
SGTC_1010 4112-3296 15.2 µM -0.408643835621054 0.338335208822447 no 2249 0.341400528159393 3272 704384
SGTC_2515 chrysin 20.77 µM -0.409690291637092 0.337958638638436 no 2250 0.341016576331223 3201 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1471 k673-0312 37 µM -0.410082008118165 0.337817720020978 no 2251 0.340872895204116 3170 24099884
SGTC_1130 3454-2858 15.9 µM -0.411355892308509 0.337359601934869 no 2252 0.340405795697071 3166 715628 YIL048W NEO1
SGTC_2732 terfenadine 20 µM -0.411515554345244 0.337302200772388 no 2253 0.340347269111832 3153 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1040 k898-0338 155 µM -0.411603784377012 0.337270482230254 no 2254 0.340314928680642 3308 20969351
SGTC_1163 k060-0048 49.9 µM -0.412531184133755 0.33693715364557 no 2255 0.339975064407621 3130 6809982
SGTC_1065 prochlorperazine maleate 2.48 µM -0.413220977730634 0.336689309126166 no 2256 0.339722359979082 3211 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1848 st056003 16.4 µM -0.413811244537446 0.336477281124081 no 2257 0.339506174158723 3233 146492
SGTC_2059 5238311 157 µM -0.415813401605397 0.335758479737086 no 2258 0.338773275740167 3071 703021
SGTC_362 0310-0100 9.03 µM -0.41783937467925 0.335031739231784 no 2259 0.338032280204171 3256 790235
SGTC_2266 7929956 200 µM -0.4188386780276 0.334673504419952 no 2260 0.337667017786953 3169 2967153
SGTC_2005 4024620 188 µM -0.418908253967438 0.334648568118332 no 2261 0.337641592282261 3148 236743
SGTC_2000 st075254 36.4 µM -0.419207423969454 0.33454135267614 no 2262 0.337532273446853 3193 17234175
SGTC_539 4859-0462 2.54 µM -0.419776936473028 0.334337290178441 no 2263 0.337324207444364 3271 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_662 k832-1615 104 µM -0.420141247415972 0.334206779287108 no 2264 0.337191135970064 3219 5878478
SGTC_237 nikkomycin 200 µM -0.420205353816262 0.334183815858992 no 2265 0.337167721999594 3278 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1405 3909-7894 12 µM -0.421463583574901 0.333733233569486 no 2266 0.336708298865534 3233 7104060
SGTC_1695 st026914 34.495 µM -0.421986172479715 0.33354616064717 no 2267 0.336517555165326 3128 3289191
SGTC_3031 9088762 49.47 µM -0.422771741974407 0.333265025541356 no 2268 0.336230903324953 3088 205253
SGTC_1832 st054113 55 µM -0.423699324539254 0.332933188192676 no 2269 0.335892553925319 3266 1251267
SGTC_875 0709-0210 25.7 µM -0.425490187222908 0.332292887540313 no 2270 0.335239686729708 3281 6251364
SGTC_1177 0983-0204 23.6 µM -0.425814268133321 0.3321770686662 no 2271 0.335121594637578 3280 766818
SGTC_3115 9123671 49.47 µM -0.42680965588103 0.331821440815583 no 2272 0.334758986461706 3278 3286988
SGTC_1467 k284-1082 293 µM -0.427786986256181 0.331472411802712 no 2273 0.334403106227239 3233 3334705
SGTC_752 1896-0090 130 µM -0.427971891190908 0.331406394095319 no 2274 0.334335792587606 3169 772567
SGTC_2756 carbadox 75.1 µM -0.431373816419103 0.33019272108654 no 2275 0.333098292596946 3172 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2956 9076196 2.52 µM -0.431850208043021 0.330022905468403 no 2276 0.332925142773733 3296 16423868
SGTC_1422 4031-0024 15.5 µM -0.433736245997697 0.329350948208103 no 2277 0.332239991298813 3219 782427
SGTC_1111 tnp00062 510.699 nM -0.436184062173331 0.328479662162416 no 2278 0.331351595248907 3324 676306
SGTC_1312 1218-2183 165 µM -0.436251834749877 0.328455552141043 no 2279 0.331327011734929 3266 6744073
SGTC_985 1493-0307 8.71 µM -0.437285775127936 0.32808781758495 no 2280 0.330952055119076 3312 3278274
SGTC_1406 3909-7906 11.9 µM -0.437387406073752 0.328051680181671 no 2281 0.330915207983144 3228 X1406
SGTC_3225 9130819 49.47 µM -0.439792719460904 0.327196881810536 no 2282 0.330043620596838 3289 4547121
SGTC_3104 9120930 49.47 µM -0.440112693693029 0.327083237768654 no 2283 0.329927744355184 3269 17014836
SGTC_1763 st044482 94.5 µM -0.440250859625383 0.327034170850394 no 2284 0.329877713654078 3264 88505
SGTC_1283 0922-0125 16.4 µM -0.44047259393451 0.326955432513285 no 2285 0.329797428710653 3237 3360884
SGTC_416 estradiol valerate 100 µM -0.440615993504341 0.326904515114685 no 2286 0.329745511167204 3239 13791 A steroid.
SGTC_2174 5790901 200 µM -0.441302158145335 0.326660920796295 no 2287 0.32949713197032 3237 786020
SGTC_477 mead ethanolamide 10 µM -0.442189555073457 0.326345996855943 no 2288 0.329176021850485 3197 16061185
SGTC_261 5-fluorouridine 15.376 µM -0.442228796201522 0.326332073620332 no 2289 0.329161825110335 3370 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2113 5491891 107.031 µM -0.443341589041686 0.325937341812996 no 2290 0.328759339128534 3227 789979
SGTC_1989 st071868 50.2 µM -0.443443741775146 0.325901115783799 no 2291 0.328722401454056 3291 16414057
SGTC_1818 st052136 56.3 µM -0.443591494836363 0.325848721594261 no 2292 0.328668977997965 3278 674169
SGTC_1058 3448-5425 97.3 µM -0.446318649399023 0.324882273448518 no 2293 0.327683543390179 3239 7279705
SGTC_1993 st073995 70.8 µM -0.447319955640476 0.32452772602472 no 2294 0.327322030261976 3210 3098394
SGTC_2017 5132927 60.65 µM -0.448850838617356 0.323985970872375 no 2295 0.326769631000727 3173 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2293 7624732 200 µM -0.449229813987955 0.323851915003119 no 2296 0.326632941207912 3199 894453
SGTC_1851 st056236 18.9 µM -0.449876662537086 0.323623156492937 no 2297 0.326399688002679 3353 5393171
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.449909209523454 0.323611647984996 no 2298 0.326387953371267 3302 229346 A bile salt which induces apoptosis.
SGTC_1941 st076221 61.8 µM -0.45032994466274 0.32346289260456 no 2299 0.326236275173452 3290 2828568
SGTC_3012 9080433 71.4286 µM -0.450382195108083 0.323444420873085 no 2300 0.326217440498451 3293 17688859
SGTC_2390 9097792 176.6 µM -0.450520036438629 0.323395692887715 no 2301 0.326167755074604 3228 4497149
SGTC_1610 st001799 48.1 µM -0.450604989304084 0.323365662895824 no 2302 0.326137135032779 3123 621897
SGTC_687 k029-0044 34.9 µM -0.450887878566174 0.323265672655426 no 2303 0.326035180107018 3302 5829338
SGTC_746 1095-0025 46.6 µM -0.451573083678066 0.32302353248667 no 2304 0.32578828212957 3345 6749286
SGTC_1977 st070720 65.3 µM -0.453101404343367 0.322483719468237 no 2305 0.325237862084295 3291 682188
SGTC_2818 7996756 12.99 µM -0.454339417000622 0.322046719297775 no 2306 0.32479227487324 3142 2241621
SGTC_82 0054-0107 293.755 µM -0.454750408304324 0.321901699786198 no 2307 0.324644405691193 3251 3104697
SGTC_1038 k292-0204 154 µM -0.454831932270432 0.321872937033493 no 2308 0.324615077740731 3131 4454212
SGTC_164 4100-3994 89.624 µM -0.456235365136047 0.32137795447516 no 2309 0.324110368496072 3350 4615967
SGTC_2794 7785382 27.27 µM -0.457814621640299 0.320821339070037 no 2310 0.323542815057031 3310 2205081
SGTC_637 1181-0519 7.26 µM -0.457913577240901 0.320786475153392 no 2311 0.323507266023472 3277 6252091 YGR060W ERG25
SGTC_1278 0874-0585 172 µM -0.45927143972189 0.320308234451253 no 2312 0.32301962725712 3258 766306
SGTC_610 4215-0184 155 µM -0.459344586867407 0.320282480404291 no 2313 0.322993367105427 3265 5605015
SGTC_1669 st015249 58.4 µM -0.465324997317882 0.318179802836217 no 2314 0.320849368124413 3329 722793
SGTC_495 decylubiquinone 155 µM -0.465435399299953 0.318141040895937 no 2315 0.320809844436382 3273 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1950 st077106 7.18 µM -0.466628558111535 0.317722252100185 no 2316 0.320382825632042 3268 13831864
SGTC_339 3091-4833 71.4 µM -0.469591114482862 0.316683428274825 no 2317 0.319323587076261 3276 3240077
SGTC_723 4182-0001 115 µM -0.470300500740516 0.316434895146534 no 2318 0.319070169889611 3231 744821 YLR208W SEC13
SGTC_2966 9084041 48.03 µM -0.470767896999734 0.316271188379514 no 2319 0.318903246049319 3097 17741380
SGTC_83 0170-0301 39.027 µM -0.471241096464087 0.316105485701122 no 2320 0.318734287089909 3299 3089716
SGTC_565 1418-0001 44.5 µM -0.472780408821754 0.315566712422284 no 2321 0.318184926306995 3371 2862145
SGTC_1368 1852-0141 284 µM -0.472877922529747 0.315532594924947 no 2322 0.318150138368928 3319 2838987
SGTC_904 1141-0088 396 µM -0.473222614503619 0.315412008817602 no 2323 0.318027182638723 3259 1378119
SGTC_3315 9136395 68.55 µM -0.473274251919212 0.315393945816565 no 2324 0.31800876468481 3403 16876844
SGTC_2821 7996764 71.43 µM -0.474505237744816 0.314963472120357 no 2325 0.317569831903201 3446 2987135
SGTC_851 0394-0702 453 µM -0.47454871830572 0.314948271630948 no 2326 0.317554332717258 3364 762646
SGTC_1986 st071812 45 µM -0.4748638207208 0.314838123474831 no 2327 0.317442020105944 3318 11838594
SGTC_1155 4088-0394 48.2 µM -0.474871330454493 0.314835498550439 no 2328 0.317439343600876 3218 2326248
SGTC_321 4534-3890 65.3 µM -0.475721177016164 0.314538506799651 no 2329 0.317136515900967 3308 699746
SGTC_428 3448-4153 16.5 µM -0.476544504634096 0.314250896897584 no 2330 0.316843254488771 3151 3834874
SGTC_408 cantharidin 100 µM -0.479102950770867 0.313357884754895 no 2331 0.315932695326977 3260 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_206 4546-0025 72.014 µM -0.480662546218115 0.312814052086217 no 2332 0.315378177253437 3344 6620745 YIL048W NEO1
SGTC_1877 wortmannin 25 µM -0.481493331151235 0.31252452258412 no 2333 0.315082959152141 3383 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1878 temozolomide 1 mM -0.481574458659878 0.312496255751009 no 2334 0.315054136946527 3349 5394 DNA alkylating agent.
SGTC_2587 piperic acid 92.2 µM -0.482073594471745 0.312322368750277 no 2335 0.314876833528815 3245 5370536
SGTC_188 3229-0966 278.469 µM -0.48211306109335 0.312308621303847 no 2336 0.314862815983659 3374 5722370
SGTC_2303 7774051 200 µM -0.482465785216795 0.312185768173507 no 2337 0.314737549147624 3392 2953184
SGTC_1717 st033143 58.0435 µM -0.48283081923691 0.312058649516975 no 2338 0.314607933005997 3393 674616
SGTC_2842 9000675 19.48 µM -0.483552515855341 0.311807393313943 no 2339 0.314351740481443 3279 2989072
SGTC_2731 amoxapine 43.43 µM -0.483958138410716 0.311666215642244 no 2340 0.314207789200735 3323 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_853 0419-0306 21 µM -0.484651858721665 0.311424829173808 no 2341 0.313961660479842 3241 762713
SGTC_1470 k295-0292 231 µM -0.484969982351401 0.311314162179619 no 2342 0.313848819369143 3351 5045612
SGTC_927 2425-1185 123 µM -0.485976680179129 0.310964070393286 no 2343 0.313491849980233 3196 730375
SGTC_3148 9097893 49.47 µM -0.487603475709228 0.310398693410132 no 2344 0.312915366595116 3212 17174100
SGTC_1463 k081-0032 34.1 µM -0.490399063670171 0.30942816017518 no 2345 0.311925769561704 3292 977755
SGTC_3168 9103419 49.47 µM -0.492645813908805 0.308649126635977 no 2346 0.311131435372329 3309 16649256
SGTC_1797 st048695 56.8 µM -0.492784356692335 0.308601116727266 no 2347 0.311082482572121 3347 592262 YIL048W NEO1
SGTC_2625 euphol 100 µM -0.492788446349624 0.308599699568026 no 2348 0.311081037580645 3381 6708538 A triterpene alcohol.
SGTC_2374 9071832 200 µM -0.493687469475327 0.308288236842774 no 2349 0.310763458024432 3373 17381698
SGTC_1236 0330-0013 258 µM -0.494298938286356 0.30807647489514 no 2350 0.31054753742129 3272 4617066
SGTC_449 xestospongin c 11.1929 µM -0.494784158893829 0.307908480278383 no 2351 0.310376243754013 3346 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1126 isoteolin 1.0172 µM -0.495180199258412 0.307771391760439 no 2352 0.310236463172271 3272 133323
SGTC_1195 1502-0147 41.1 µM -0.496077842208427 0.307460773936307 no 2353 0.309919745814009 3318 817940
SGTC_1489 4065-0444 182 µM -0.496217303072738 0.307412527676079 no 2354 0.309870552177367 3354 2877968
SGTC_1916 st067606 49.2 µM -0.49791311710415 0.306826130355608 no 2355 0.309272640752466 3309 19590279
SGTC_2035 5154463 94.595 µM -0.497961010627944 0.306809576369136 no 2356 0.309255761738053 3395 2769623
SGTC_1164 k060-0068 93.7 µM -0.498103282253221 0.306760403723404 no 2357 0.309205623620851 3334 5963676
SGTC_2923 7992654 58.14 µM -0.498194098445685 0.306729017185343 no 2358 0.309173620833348 3302 2985126
SGTC_143 4032-1194 15.74 µM -0.499291392519795 0.306349898822877 no 2359 0.308787059029551 3305 1806963
SGTC_1646 st011709 75.6 µM -0.499668677325261 0.306219593653913 no 2360 0.3086541956121 3371 5757843
SGTC_1773 st048542 73.5835 µM -0.501629543317051 0.305542752336248 no 2361 0.307964066935451 3252 3237138
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.501700236006871 0.305518363396346 no 2362 0.307939199234615 3338 1241132 A phosphatase inhibitor.
SGTC_1635 st007035 42.4 µM -0.502691593121992 0.305176436672622 no 2363 0.307590560620652 3375 3716403
SGTC_3182 9108849 49.47 µM -0.502876360982198 0.305112727593368 no 2364 0.307525601001737 3384 17133045
SGTC_1914 st062367 72.6 µM -0.503006043853025 0.305068015679442 no 2365 0.307480011450319 3263 978205
SGTC_1932 st074806 40.9 µM -0.507457297321067 0.30353508503616 no 2366 0.305916995797163 3485 17251235
SGTC_1530 rhein 70.4 µM -0.508976293401554 0.303012758804748 no 2367 0.305384420568435 3369 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1459 k035-0031 35.7 µM -0.509176473470917 0.302943954331127 no 2368 0.305314266107791 3258 3877128 YMR208W ERG12
SGTC_978 1416-0512 87.4 µM -0.509565558630027 0.302810240748501 no 2369 0.305177929036632 3368 6814003
SGTC_1872 amphotericin b 148 nM -0.509844656189031 0.302714341948858 no 2370 0.305080148728279 3358 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1203 3992-3522 103 µM -0.511061069808145 0.302296537361425 no 2371 0.304654147380306 3560 5322312
SGTC_2256 7954252 200 µM -0.511827680319832 0.302033360734383 no 2372 0.304385807969016 3340 2972920
SGTC_676 falcarinol 140 µM -0.511995817567002 0.301975653145964 no 2373 0.304326968360644 3457 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1574 spiramycin 23.7 µM -0.512770127699921 0.301709960568719 no 2374 0.304056064019215 3319 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1694 st024011 44.9 µM -0.514851530152349 0.300996281012365 no 2375 0.303328386667733 3411 2787533
SGTC_2773 thioridazine 9.09 µM -0.516461434556247 0.300444793131901 no 2376 0.302766083772961 3393 5452 An antipsychotic.
SGTC_2404 5161160 200 µM -0.516547876806924 0.300415194442987 no 2377 0.302735904676768 3349 2831543
SGTC_1178 0988-0033 191 µM -0.517292755870685 0.300160195026488 no 2378 0.302475905096201 3400 5392207
SGTC_306 1672-3436 11.6 µM -0.518043852323496 0.299903166324268 no 2379 0.302213836761538 3397 6797378
SGTC_1449 4112-4002 201 µM -0.518503807298647 0.299745816789795 no 2380 0.302053402193512 3348 2059539
SGTC_2108 5365811 200 µM -0.520283194119048 0.299137445085498 no 2381 0.30143310378445 3393 780283
SGTC_1817 st052116 64.4 µM -0.520581450381035 0.299035526246917 no 2382 0.301329187084145 3417 4361398
SGTC_1733 st037357 54.9 µM -0.520658828474492 0.299009087515948 no 2383 0.301302230097403 3261 1272339 YGL099W LSG1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.521141175577812 0.298844301948601 no 2384 0.301134214462507 3441 688801
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.524239361260451 0.297786845439287 no 2385 0.300056033535457 3396 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2648 atorvastatin 78.68 µM -0.524990658030369 0.29753067410615 no 2386 0.299794842588958 3423 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1444 4112-3581 28 µM -0.5252295855444 0.297449227550176 no 2387 0.299711800185496 3396 2877249
SGTC_1995 st072814 61.1 µM -0.528563408910351 0.296313844470512 no 2388 0.298554174625593 3307 5769371
SGTC_1699 st031318 29.054 µM -0.529179547335367 0.296104227142713 no 2389 0.298340451667186 3413 5340658
SGTC_418 lividomycin a 100 µM -0.530194346445542 0.295759129314267 no 2390 0.29798859522562 3438 72394 An antibiotic.
SGTC_1845 st056753 3.01 µM -0.532241414959319 0.295063555582182 no 2391 0.297279401179817 3271 5375839
SGTC_2424 5537928 59.2 µM -0.53284946003953 0.294857093083894 no 2392 0.297068896442369 3352 5382802
SGTC_1370 2001-0092 44.6 µM -0.533460065640532 0.2946498281931 no 2393 0.296857573877771 3514 790957
SGTC_2251 lansoprazole 556 µM -0.533516435234288 0.294630697401651 no 2394 0.296838068572273 3243 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2528 xanthyletin 44.79 µM -0.53396909711635 0.294477093159354 no 2395 0.296681457381788 3322 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_873 0591-4978 488 µM -0.534195378328481 0.294400321772029 no 2396 0.296603183179644 3514 3305145
SGTC_2121 5257820 149.641 µM -0.534816312138458 0.294189702405091 no 2397 0.296388441096207 3457 791256
SGTC_2815 7968870 71.43 µM -0.535436481109713 0.293979411985792 no 2398 0.296174034691733 3382 2977326 YHR190W ERG9
SGTC_2962 9082311 13.18 µM -0.536308676646461 0.293683780631809 no 2399 0.29587261748559 3300 16459453
SGTC_1729 st035615 45.989 µM -0.536382489703264 0.293658767955467 no 2400 0.295847115308828 3369 17385451
SGTC_1262 0737-0114 49.6 µM -0.539070170528973 0.292748678878172 no 2401 0.294919218616239 3477 765919
SGTC_2859 9028643 45.46 µM -0.540351106685734 0.292315396018973 no 2402 0.294477459788886 3388 17151580
SGTC_32 0928-0142 34.1 µM -0.540696290253822 0.292198687039419 no 2403 0.294358467952862 3416 2244242
SGTC_595 3909-8003 73.7 µM -0.540951164400357 0.292112526223401 no 2404 0.294270621872768 3447 699517
SGTC_2929 9013348 24.6 µM -0.541928630831069 0.291782201033005 no 2405 0.293933836178311 3376 2995952
SGTC_2569 tetrandrine 100 µM -0.542395060861925 0.291624636945426 no 2406 0.293773190730605 3336 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2727 riluzole 51.77 µM -0.543792961949291 0.291152651647814 no 2407 0.293291976275135 3416 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_232 clozapine 119 µM -0.544507451331134 0.290911550321076 no 2408 0.293046161116846 3403 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3077 9117319 49.47 µM -0.544924499490311 0.29077086237954 no 2409 0.292902722753454 3439 17154678
SGTC_1701 st028638 40.4 µM -0.546482757119184 0.290245478037087 no 2410 0.292367068586327 3456 3490878
SGTC_2281 7943571 200 µM -0.547625500962408 0.289860471759799 no 2411 0.291974537848092 3507 1244024
SGTC_1870 st057514 26.5 µM -0.549028626493707 0.289388067180246 no 2412 0.291492902314039 3346 5393161
SGTC_380 3970-0968 6 µM -0.550413540498828 0.28892214906865 no 2413 0.29101788174671 3354 2891601
SGTC_823 0417-1665 178 µM -0.550982966477733 0.288730683043019 no 2414 0.290822675637038 3405 3429856
SGTC_2098 5376439 882.5 nM -0.551235423409031 0.288645815054231 no 2415 0.290736149938943 3425 2844116
SGTC_1057 3448-5381 134 µM -0.552058983074079 0.288369042210706 no 2416 0.290453971360132 3429 5497911
SGTC_2456 5770359 74.46 µM -0.552410521465439 0.288250939182077 no 2417 0.290333561818496 3468 3118787
SGTC_649 1123-0311 367 µM -0.553091599591269 0.288022188744326 no 2418 0.290100344292105 3424 693629 YIL048W NEO1
SGTC_527 4476-4215 268 µM -0.553114100784926 0.288014632838943 no 2419 0.290092640840841 3334 4418754
SGTC_1295 1013-0063 9.78 µM -0.553360384002174 0.287931937002044 no 2420 0.290008330214984 3485 6826038
SGTC_1388 3346-4487 254 µM -0.553726392337637 0.287809061134774 no 2421 0.289883055076127 3434 3345614
SGTC_907 3448-6986 75.5 µM -0.554140932554135 0.287669922125276 no 2422 0.289741199395861 3505 590582
SGTC_3079 9117512 49.47 µM -0.554958136338843 0.287395723603592 no 2423 0.289461647667895 3462 7185044
SGTC_2480 5767542 37.17 µM -0.555303577426243 0.287279854039202 no 2424 0.289343516163985 3407 2867358
SGTC_1959 st077091 55.8 µM -0.555702620303717 0.287146032620244 no 2425 0.289207082503974 3398 821356 YKL052C ASK1
SGTC_2768 sulfasalazine 50.2 µM -0.556443523517252 0.286897644586079 no 2426 0.288953846260655 3512 5384001 An antioxidant and salicylic acid derivative.
SGTC_11 0438-0307 1.3 µM -0.557236635076472 0.286631866561364 no 2427 0.288682881195021 3467 4011476
SGTC_545 4218-0007 221 µM -0.559844444483143 0.28575879294821 no 2428 0.287792772713492 3454 2840508
SGTC_1526 st051518 75 µM -0.559858172550115 0.285754200250672 no 2429 0.287788090424252 3348 673993
SGTC_370 0180-0345 38.7 µM -0.559862949824955 0.285752602031098 no 2430 0.287786461027575 3375 3989527
SGTC_1518 st038567 90.8 µM -0.560644497510939 0.285491195415583 no 2431 0.287519955363105 3459 77966
SGTC_1257 0669-0121 16 µM -0.563245308935395 0.284622114939024 no 2432 0.286633926968238 3438 4307855
SGTC_2040 5100729 123 µM -0.564372352292516 0.28424589772242 no 2433 0.286250375347307 3403 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1232 0279-0259 161 µM -0.565310807220242 0.283932814526745 no 2434 0.285931189583268 3426 1560000
SGTC_2126 5251174 33.877 µM -0.565824000636806 0.283761675029497 no 2435 0.285756714660964 3525 790722
SGTC_1184 1269-1718 139 µM -0.567370387232511 0.283246285633501 no 2436 0.285231282299742 3497 5403821
SGTC_3169 9102970 49.47 µM -0.567408728201144 0.283233512822035 no 2437 0.285218260628173 3498 17027839
SGTC_2882 9058044 58.44 µM -0.568042090194569 0.283022556229023 no 2438 0.285003194078503 3429 18076804
SGTC_3111 9122088 49.47 µM -0.568611460246898 0.282832978105371 no 2439 0.284809922880368 3372 16876704
SGTC_2092 5303694 80.6725 µM -0.56874903199054 0.282787181206163 no 2440 0.284763233888904 3415 1963699
SGTC_2716 st080858 38.6235 µM -0.568814633503886 0.282765344066939 no 2441 0.284740971384531 3474 5296050
SGTC_1684 st024538 14.6195 µM -0.569118683053195 0.282664143988927 no 2442 0.284637800094771 3399 6732859
SGTC_2951 9072950 58.06 µM -0.571743826564868 0.281791113958477 no 2443 0.283747769169604 3511 16488155
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.575685308810912 0.28048276173557 no 2444 0.282413953596213 3434 688667
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.576857688343404 0.28009416528503 no 2445 0.282017797720474 3537 23847180
SGTC_1264 0783-0040 158 µM -0.578322550341382 0.279608989708563 no 2446 0.28152318624719 3414 2855798
SGTC_3322 9139058 2.11 µM -0.578593952930555 0.279519143523942 no 2447 0.281431592978989 3510 4908926 YPR165W RHO1
SGTC_745 0469-0705 296 µM -0.578613079830977 0.279512812208123 no 2448 0.281425138552354 3592 3486736
SGTC_2759 disulfiram 3.38 µM -0.579762636269866 0.279132418203966 no 2449 0.281037348696456 3422 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1774 st048371 48.465 µM -0.579786930201603 0.27912438193626 no 2450 0.281029156200045 3413 4242727
SGTC_1747 st037496 66.6 µM -0.57986479112801 0.279098626828339 no 2451 0.281002900405933 3440 723305
SGTC_1286 0929-0070 131 µM -0.581316387114659 0.278618674560435 no 2452 0.280513619094503 3530 1420408
SGTC_2777 climbazole 1.536 µM -0.581355907407841 0.278605613286406 no 2453 0.280500303978917 3455 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2443 5493264 126.67 µM -0.581691462839318 0.27849472578499 no 2454 0.280387261493095 3500 5340055
SGTC_2602 kawain 100 µM -0.583350309970638 0.277946859982219 no 2455 0.279828750534181 3498 5369129
SGTC_167 3672-0051 66.205 µM -0.58408309932364 0.277705009979231 no 2456 0.279582202425758 3469 3237971
SGTC_2144 5628481 200 µM -0.58419914856123 0.277666718486055 no 2457 0.279543167155497 3454 2818399
SGTC_40 0327-0103 19.753 µM -0.584369671169648 0.277610457692157 no 2458 0.279485813578165 3407 409036
SGTC_2780 5215298 71.43 µM -0.585646522863121 0.277189361068013 no 2459 0.279056538939295 3514 2834131
SGTC_1640 st009078 66.4 µM -0.586851415096509 0.276792282947955 no 2460 0.278651751167569 3501 690618
SGTC_2907 7721985 69.9 µM -0.587976930871714 0.276421615610517 no 2461 0.278273888656041 3458 3267881
SGTC_979 1426-2828 121 µM -0.58813826973203 0.276368501663693 no 2462 0.278219743827248 3541 747872
SGTC_1042 0350-0096 82 µM -0.590109365104251 0.27572000695654 no 2463 0.277558665309775 3470 3122515
SGTC_1002 4049-0206 172 µM -0.590909767190523 0.275456886603346 no 2464 0.277290440657321 3495 4662749
SGTC_1545 lovastatin 49.4 µM -0.591241872724723 0.275347748089707 no 2465 0.277179185203402 3499 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_446 go6976 132 µM -0.592390153862545 0.274970557116822 no 2466 0.276794679056802 3485 3501 A protein kinase C inhibitor.
SGTC_3053 9095903 49.47 µM -0.592907210556149 0.274800795885013 no 2467 0.276621626082647 3531 17174018
SGTC_2389 9091542 195.52 µM -0.594075963425516 0.274417258766778 no 2468 0.27623065334468 3449 3626624 YOL127W RPL25
SGTC_2829 7992743 58.44 µM -0.594572880224892 0.274254270982826 no 2469 0.276064506283424 3469 16462845
SGTC_2223 6903751 107.57 µM -0.594925320641201 0.274138700166679 no 2470 0.275946695501613 3484 5598863
SGTC_256 clotrimazole 625 nM -0.596234442356974 0.273709629106603 no 2471 0.275509309778019 3494 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3223 9129970 49.47 µM -0.597782470246064 0.273202684418377 no 2472 0.274992544417025 3526 17248386
SGTC_3146 9095609 49.47 µM -0.599713631801086 0.272570924817481 no 2473 0.274348550876602 3487 17173999
SGTC_1299 1079-1439 3.74 µM -0.599805025579628 0.272541044267653 no 2474 0.274318091823875 3428 323161
SGTC_2997 9067075 71.4286 µM -0.599814551420405 0.27253792995494 no 2475 0.274314917217135 3491 27209819
SGTC_2380 9035439 200 µM -0.600712792169197 0.272244344724746 no 2476 0.27401564866611 3594 6462575
SGTC_1976 st070609 63.5 µM -0.602182363602604 0.27176436223432 no 2477 0.273526376989908 3491 682556
SGTC_134 0269-0018 6.916 µM -0.602451481433299 0.271676510250369 no 2478 0.273436825125923 3450 4378915
SGTC_2202 7226349 200 µM -0.604882349470632 0.270883608398138 no 2479 0.272628585866805 3475 844334
SGTC_161 4065-0411 162.148 µM -0.605266911515603 0.270758277624435 no 2480 0.272500831558896 3492 1906281 YLR208W SEC13
SGTC_1036 k216-0215 33.5 µM -0.609214516608235 0.269473408817603 no 2481 0.271191129724632 3532 622330
SGTC_485 niflumic acid 177 µM -0.610015926634251 0.269212939100352 no 2482 0.270925628673561 3548 4488 A COX2 inhibitor.
SGTC_1996 st072960 66.8 µM -0.61130043891254 0.268795717849726 no 2483 0.270500350240554 3560 1719405
SGTC_2095 5432005 200 µM -0.613248443051684 0.268163608756815 no 2484 0.269856038948912 3515 783734
SGTC_94 0334-0113 514.748 µM -0.617402625922973 0.266818118683213 no 2485 0.26848459520761 3497 6795178
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.618057700340094 0.266606259724663 no 2486 0.268268652091508 3563 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2635 hydroquinidine 100 µM -0.618545571211514 0.266448531688717 no 2487 0.268107883860742 3531 442912 An experimental heart treatment.
SGTC_2803 7707263 71.43 µM -0.618660304235261 0.266411445504376 no 2488 0.268070082898216 3494 2199229
SGTC_830 4076-0286 57.8 µM -0.621534596275795 0.265483215349713 no 2489 0.267123969429962 3597 6866659
SGTC_2984 9022109 38.96 µM -0.621571598882567 0.265471276353524 no 2490 0.267111800503349 3614 6459207
SGTC_453 enantio-paf c16 10 µM -0.622389754674721 0.265207365682183 no 2491 0.266842807803272 3562 13871343 A lipid and platelet activating factor
SGTC_1446 4239-0190 62 µM -0.622743835601395 0.265093191912265 no 2492 0.266726435769141 3521 1340085
SGTC_159 3970-0959 50 µM -0.624718917128048 0.26445678316665 no 2493 0.266077777577714 3654 6615653
SGTC_1228 0124-0032 52.5 µM -0.625193314786814 0.264304039129204 no 2494 0.265922094513632 3562 X1228
SGTC_1614 st002383 48.6 µM -0.62751629132269 0.263556748534416 no 2495 0.265160430301218 3567 1947235
SGTC_2253 7938677 135.83 µM -0.627710179154837 0.263494424519562 no 2496 0.26509690793382 3594 2301972
SGTC_3067 9117431 49.47 µM -0.628418820887019 0.263266700130521 no 2497 0.264864805446321 3526 17150885
SGTC_3298 9116858 71.43 µM -0.628649649563128 0.263192544273451 no 2498 0.264789224093534 3581 2506942
SGTC_291 SEC14.278 35.5 µM -0.632085540963578 0.262089995170854 no 2499 0.263665491389917 3579 1068044
SGTC_2653 dihydrofissinolide 100 µM -0.632103462733822 0.262084250435247 no 2500 0.263659636331784 3575 6857746
SGTC_1355 1499-0035 1.68 µM -0.632155265616081 0.262067645638138 no 2501 0.263642712657448 3565 1548538
SGTC_1389 3405-0187 19 µM -0.632450047771931 0.261973166993542 no 2502 0.263546419740072 3506 799890
SGTC_2269 7935389 174.42 µM -0.633012694991124 0.261792885207831 no 2503 0.26336267641936 3551 97605
SGTC_3201 9113999 49.47 µM -0.634977180710779 0.261163929801989 no 2504 0.262721648924442 3557 16649224
SGTC_1886 st057356 49.9 µM -0.635708575236106 0.260929962965224 no 2505 0.262483193072103 3520 24207747
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.63772229171741 0.260286349740838 no 2506 0.26182723597624 3574 6708760
SGTC_2926 9010726 65.15 µM -0.638579694637364 0.26001255973224 no 2507 0.261548197113989 3563 2994293
SGTC_569 4130-2812 160 µM -0.639989515581962 0.259562692027514 no 2508 0.261089707792961 3503 743552
SGTC_2345 9052315 157.45 µM -0.641580057326531 0.259055640010507 no 2509 0.260572942501137 3558 6469265
SGTC_1849 st056239 19.2 µM -0.641745206720371 0.259003021069644 no 2510 0.260519315833176 3481 5393181
SGTC_2814 7977482 42.97 µM -0.64198098248453 0.258927909144882 no 2511 0.260442765494159 3609 6456762
SGTC_797 k781-0471 270 µM -0.642249786052964 0.258842289183477 no 2512 0.260355506009169 3556 23738129
SGTC_777 1315-0167 517 µM -0.643294331665214 0.258509717116994 no 2513 0.26001656681288 3551 4221767
SGTC_1436 4092-1007 8.32 µM -0.643476224494506 0.258451827033396 no 2514 0.259957568619571 3557 2881121
SGTC_921 1561-0023 372 µM -0.644078009442915 0.258260347945023 no 2515 0.259762424741506 3596 24050882
SGTC_392 N-ethylmaleimide 8.33 µM -0.644129070711134 0.258244104387863 no 2516 0.259745870323241 3561 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2623 humulene 100 µM -0.644681865550907 0.258068283778204 no 2517 0.259566685251263 3536 6187145 An anti-inflammatory.
SGTC_1292 0kpi-0043 232 µM -0.646923399513638 0.25735598356229 no 2518 0.25884076037015 3560 3333905
SGTC_489 paxilline 115 µM -0.647506861840382 0.25717074238803 no 2519 0.2586519774789 3583 105008 A toxic potassium channel blocker.
SGTC_2233 sulbentine 40.3845 µM -0.64780311110712 0.257076713909153 no 2520 0.25855615146507 3567 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1277 0873-0036 22 µM -0.648296531347404 0.256920143754417 no 2521 0.258396588533321 3605 5965735
SGTC_1674 st016616 23.6 µM -0.649881961239128 0.256417397469821 no 2522 0.257884235525452 3578 625830
SGTC_2308 7584454 197.62 µM -0.650059494045712 0.256361133025057 no 2523 0.257826896245073 3653 893577
SGTC_2343 7990716 14.84 µM -0.651017632173522 0.256057586957616 no 2524 0.257517552474452 3580 6456862
SGTC_1391 3442-0225 151 µM -0.651518164065419 0.255899088905578 no 2525 0.257356027811946 3555 5227075
SGTC_1844 rapamycin 4 nM -0.652393393999305 0.255622062338348 no 2526 0.257073712404241 3584 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2786 7743617 45.45 µM -0.652436907724269 0.255608293522575 no 2527 0.257059680759648 3511 583674
SGTC_174 3553-0389 74.3 µM -0.65445891644422 0.254968907547696 no 2528 0.256408093714853 3599 738071
SGTC_2749 bexarotene 57.39 µM -0.654753333230423 0.254875878901929 no 2529 0.25631329050395 3584 82146 An retinoic acid receptor inhibitor.
SGTC_2006 4011487 200 µM -0.654865438132176 0.25484046111129 no 2530 0.25627719714606 3630 45595294
SGTC_2405 ticlatone 3.52 µM -0.654926564758083 0.254821150195088 no 2531 0.256257517899084 3504 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.65510825513927 0.254763755708955 no 2532 0.256199028729694 3648 5024745
SGTC_2698 st077697 67.5 µM -0.656388483000197 0.254359534271743 no 2533 0.255787099392275 3548 3154499
SGTC_609 0986-0026 86.3 µM -0.658110580870044 0.253816326710554 no 2534 0.255233538675971 3603 2848610
SGTC_1302 1159-0335 255 µM -0.658167730843081 0.253798310134041 no 2535 0.255215178815035 3608 649284
SGTC_3326 9140064 16.379 µM -0.659863486253525 0.253264027497891 no 2536 0.254670718964495 3591 1868434
SGTC_2326 6164455 177.58 µM -0.661232465624643 0.252833134185729 no 2537 0.254231621955831 3597 2888790
SGTC_376 3970-0862 59.1 µM -0.662342690532962 0.25248396878591 no 2538 0.253875811581499 3603 3135186
SGTC_2162 5663267 200 µM -0.664091868293973 0.251934368862405 no 2539 0.253315757181883 3621 6456493
SGTC_1037 k284-1091 78.7 µM -0.665459124543076 0.251505210543479 no 2540 0.252878439686311 3607 3334711
SGTC_1259 0671-0132 43 µM -0.665938942509315 0.251354695521462 no 2541 0.252725063957506 3567 X1259
SGTC_1212 0520-0165 585 µM -0.666171645074973 0.251281715755645 no 2542 0.252650697296683 3754 5403258
SGTC_268 camptothecin 39.6153 µM -0.667529550415848 0.250856075426774 no 2543 0.252216970356867 3638 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1630 st005209 31.3 µM -0.667606338806555 0.250832017235394 no 2544 0.252192455202979 3631 3367314
SGTC_2097 5376186 200 µM -0.667663682364559 0.250814052005204 no 2545 0.252174148748113 3597 742755
SGTC_1731 st035964 63 µM -0.667998652986633 0.25070912228192 no 2546 0.25206722616368 3602 6739575
SGTC_3176 9106582 49.47 µM -0.668695072468273 0.250491042944995 no 2547 0.251845005721176 3535 17018027
SGTC_354 2783-3500 4.88 µM -0.669107354147959 0.250361986940617 no 2548 0.251713499540665 3593 6740761
SGTC_1657 st012939 43.4 µM -0.67079423488257 0.24983431218515 no 2549 0.251175810312082 3652 24207257
SGTC_2897 9048598 12.99 µM -0.6722208172785 0.249388522810113 no 2550 0.250721565098009 3611 6467404
SGTC_1546 5-methoxyflavanone 78.7 µM -0.672399411222178 0.24933274420287 no 2551 0.250664728765442 3664 147795
SGTC_457 grayanotoxin iii 135 µM -0.672874403244109 0.24918442658653 no 2552 0.250513598935986 3599 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1020 4335-0961 93.3 µM -0.673997017798691 0.248834073568987 no 2553 0.250156604827971 3576 669075
SGTC_1411 3909-8223 150 µM -0.674156931129004 0.24878418809976 no 2554 0.250105773972295 3643 X1411
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.674341880653315 0.248726499151774 no 2555 0.250046991819694 3769 16725076
SGTC_3088 9117578 49.47 µM -0.674921032137689 0.24854589789877 no 2556 0.249862968638836 3691 678341
SGTC_1376 2910-0861 41.3 µM -0.675258681557837 0.248440638337103 no 2557 0.249755715004319 3646 1112859
SGTC_2384 9036245 200 µM -0.675612018463486 0.248330513768126 no 2558 0.249643504454379 3634 6462766
SGTC_221 trifluoperazine 10.304 µM -0.675811800253607 0.248268259264549 no 2559 0.249580070841332 3652 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1169 aniline yellow 25.8 µM -0.675994792828042 0.248211243793071 no 2560 0.249521975562102 3600 6051 A DNA damaging agent.
SGTC_2589 lobaric acid 100 µM -0.67622413429521 0.248139797137305 no 2561 0.249449175888028 3627 73157 A novel microtubule depolymerizer.
SGTC_361 000s-0510 1.45 µM -0.678092607749203 0.247558121306434 no 2562 0.248856488730976 3629 660
SGTC_2387 9077560 195.08 µM -0.678553425130892 0.247414775975577 no 2563 0.248710430960147 3632 5303272
SGTC_3316 9136639 10.545 µM -0.678666795155359 0.247379517041015 no 2564 0.248674504910562 3646 4903665
SGTC_604 1000-0114 314 µM -0.679013751431192 0.247271627705541 no 2565 0.248564574429953 3673 1572745
SGTC_2730 imipramine 71.33 µM -0.680679416845361 0.246754023779803 no 2566 0.248037181595979 3663 3696 A tricyclic antidepressant.
SGTC_2110 5483698 200 µM -0.680938972826495 0.24667341928249 no 2567 0.247955053243991 3655 2848765 YHR062C RPP1
SGTC_2514 salinomycin 42.74 µM -0.684902538574997 0.245444296951584 no 2568 0.246702711993449 3701 23682228 A polyether potassium ionophore.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.685164423032911 0.245363201284974 no 2569 0.24662008557738 3691 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3222 9128301 49.47 µM -0.687823746063891 0.244540526183693 no 2570 0.245781890287045 3683 4911358
SGTC_3162 9099653 49.47 µM -0.688078921340304 0.244461664615099 no 2571 0.245701541771744 3632 25237511
SGTC_651 3253-0966 34.4 µM -0.688402364491287 0.244361724648228 no 2572 0.245599717628387 3677 781462
SGTC_458 nppb 133 µM -0.688623579047243 0.244293384745219 no 2573 0.245530089440651 3686 4549 A chloride channel blocker.
SGTC_847 0342-0274 5.54 µM -0.689526856783951 0.24401444173406 no 2574 0.245245889161414 3663 18097
SGTC_1395 3486-0190 4.35 µM -0.689810736262791 0.243926811839162 no 2575 0.245156608070427 3682 6748079
SGTC_2566 crystal violet carbinol 226 nM -0.692851351237404 0.242989279450195 no 2576 0.244201421170673 3613 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1807 st050092 58.9 µM -0.693894053041293 0.242668225890003 no 2577 0.243874326676209 3634 5008496
SGTC_591 4299-0174 154 µM -0.694526704057053 0.242473541201203 no 2578 0.243675980000814 3649 5509088
SGTC_2416 tofa 880 nM -0.694593544184448 0.24245297753795 no 2579 0.2436550295913 3652 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_186 3455-3465 67.277 µM -0.694607744619214 0.242448608832549 no 2580 0.243650578723802 3626 755278
SGTC_520 3584-0023 682 µM -0.695813604839681 0.242077786496741 no 2581 0.243272784010533 3665 1340790
SGTC_1716 st033144 30.6155 µM -0.695837100378882 0.242070564278454 no 2582 0.243265426029433 3679 674617
SGTC_2915 7971052 15.16 µM -0.695909651257037 0.242048263834632 no 2583 0.243242706391164 3542 5741558
SGTC_887 0885-0007 9.62 µM -0.696406396903682 0.241895605768698 no 2584 0.24308717904403 3698 5719458
SGTC_1205 4161-2785 76 µM -0.697773846630261 0.241475636037074 no 2585 0.242659318684991 3677 3498106
SGTC_2935 9038016 29.96 µM -0.69885800288702 0.24114295275777 no 2586 0.242320387803824 3667 6463195
SGTC_1767 st044992 70.3 µM -0.69888761470642 0.241133869596707 no 2587 0.242311134104014 3666 9600693
SGTC_2439 5492030 7.2 µM -0.69930368102166 0.241006264640154 no 2588 0.242181133543789 3654 5722370
SGTC_1964 st076914 61 µM -0.699333691521384 0.240997062026265 no 2589 0.242171758179154 3707 24208661
SGTC_1191 1487-1166 10.6 µM -0.701125582376511 0.240447931518203 no 2590 0.24161232319847 3739 3955771
SGTC_2769 toremifene 3.73 µM -0.70235882527753 0.240070396662479 no 2591 0.241227708189186 3694 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3267 9137951 49.47 µM -0.702577238335546 0.240003567184064 no 2592 0.241159625782842 3675 16643986
SGTC_2134 5324836 1.464 µM -0.704549506469015 0.23940055716206 no 2593 0.240545315484924 3661 699272
SGTC_1923 st058458 19.1 µM -0.704779066728305 0.239330424188248 no 2594 0.240473868825443 3724 3534982
SGTC_1508 1080-0625 72.9 µM -0.707797056421606 0.23840944237913 no 2595 0.239535647301021 3624 767111
SGTC_588 3970-1144 52.9 µM -0.708455062688288 0.238208900552504 no 2596 0.239331354420143 3618 1888707
SGTC_779 1360-0071 233 µM -0.709848621563244 0.237784488250545 no 2597 0.23889900705345 3739 7566
SGTC_3181 9108277 49.47 µM -0.711618619465639 0.237246028839279 no 2598 0.238350486965203 3656 17097298
SGTC_1852 st056254 31.4 µM -0.711823165043344 0.23718384626332 no 2599 0.238287143042112 3656 442583
SGTC_1629 st005085 44.9 µM -0.711995218918616 0.237131548213125 no 2600 0.238233868330037 3688 24207091
SGTC_2208 7283366 200 µM -0.712054462983628 0.237113541662785 no 2601 0.238215525525284 3687 898663
SGTC_1631 benzylvanillin 81.9 µM -0.712864619464968 0.236867379341176 no 2602 0.23796476721444 3715 75506
SGTC_2852 9023854 51.95 µM -0.713325160778492 0.236727508643604 no 2603 0.237822285757079 3770 19798528
SGTC_1700 st030840 7.9285 µM -0.715272841590687 0.2361364823956 no 2604 0.237220233363225 3738 5499307
SGTC_1575 cyproterone acetate 48 µM -0.715483211274294 0.236072694119619 no 2605 0.237155255607825 3670 9880 An androgen receptor antagonist and liver toxin.
SGTC_571 k831-0106 44.2 µM -0.716881008641036 0.235649095332187 no 2606 0.236723760580192 3661 4783639
SGTC_3130 9127414 49.47 µM -0.717035488537572 0.235602306349198 no 2607 0.23667609970334 3705 1494646
SGTC_1746 st038117 42 µM -0.7183079385518 0.235217100788865 no 2608 0.236283718213086 3755 2898218
SGTC_2657 nystatin 74.44 µM -0.72220315123998 0.234040077499317 no 2609 0.23508479309452 3726 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2219 9098279 200 µM -0.723654888739244 0.233602239324329 no 2610 0.234638817319559 3686 902349
SGTC_1147 3809-1045 12.3 µM -0.723753808214585 0.233572422146916 no 2611 0.234608446155324 3684 325925
SGTC_1608 st001473 40.5 µM -0.727987699925825 0.232298185520702 no 2612 0.233310557887903 3683 7292267
SGTC_24 0417-1663 219 µM -0.728044687717356 0.23228106083334 no 2613 0.233293115649854 3680 4329390
SGTC_1290 0986-0249 10.2 µM -0.72844008640893 0.232162263870892 no 2614 0.23317211600891 3671 53329
SGTC_2444 5485484 36.41 µM -0.728640838087153 0.232101961265906 no 2615 0.233110695452382 3801 6790631
SGTC_802 4112-3352 742 µM -0.729788153991794 0.231757493207913 no 2616 0.232759843253887 3807 704594
SGTC_2517 totarol 10 µM -0.731136082591211 0.23135315769766 no 2617 0.232348018336746 3705 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_743 1275-0778 158 µM -0.731261194634051 0.231315648046048 no 2618 0.232309814138149 3735 2849257 YMR203W TOM40
SGTC_1188 1403-0014 4.57 µM -0.731438572128624 0.231262474582795 no 2619 0.232255656157692 3758 9614867
SGTC_792 4534-1957 155 µM -0.733391670036552 0.230677434384694 no 2620 0.231659789150418 3707 1717904
SGTC_152 4469-0003 551.229 µM -0.733720629701695 0.230578977674211 no 2621 0.231559511354165 3689 697280
SGTC_3072 9116419 49.47 µM -0.735045570197264 0.230182664536073 no 2622 0.231155870707871 3737 17170162
SGTC_2083 5306046 65.942 µM -0.736337149997058 0.229796697214266 no 2623 0.230762771528307 3762 539837
SGTC_207 4185-0010 4.486 µM -0.736845346794522 0.229644930384723 no 2624 0.230608201554701 3794 3761753
SGTC_1032 k061-1018 98.7 µM -0.737040877397645 0.229586552494247 no 2625 0.230548745599142 3849 4005393
SGTC_49 0717-0965 32.132 µM -0.737378848007336 0.229485667123657 no 2626 0.230445997411787 3804 5889349 YGL099W LSG1
SGTC_2459 5811157 9.22 µM -0.738686476795687 0.229095569592936 no 2627 0.230048699653771 3717 2870684 YBR192W RIM2
SGTC_2107 5363541 170.161 µM -0.739800766089579 0.228763443686133 no 2628 0.229710447053821 3694 244052
SGTC_1450 4112-4260 37.6 µM -0.746420826332975 0.226795846547368 no 2629 0.227706621177247 3724 1633175
SGTC_2100 5377183 190 µM -0.748202140027231 0.226268043960076 no 2630 0.2271691201971 3784 2844202
SGTC_929 2805-0021 398 µM -0.749234263142547 0.22596254405603 no 2631 0.226858010612768 3821 3098024
SGTC_3281 9140613 49.47 µM -0.749243843396216 0.225959709472966 no 2632 0.226855123993661 3717 16013766
SGTC_2981 9013952 38.96 µM -0.751152424527313 0.225395404042819 no 2633 0.226280464223262 3670 2996344
SGTC_2479 5617353 43.85 µM -0.75187814102273 0.22518104280909 no 2634 0.226062172295858 3780 2731746
SGTC_2001 4023502 57.655 µM -0.753575246894936 0.224680204868129 no 2635 0.225552156178421 3781 108941 YCR052W RSC6
SGTC_3248 9135562 49.47 µM -0.754386804620059 0.22444092714596 no 2636 0.225308496307876 3785 17650701
SGTC_1387 3342-1166 1.8 µM -0.754924381913886 0.224282508810006 no 2637 0.225147177677233 3772 3418228
SGTC_274 sirtinol 40.1 µM -0.755876746171612 0.224002013061213 no 2638 0.224861548601874 3814 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_50 0929-0078 56.389 µM -0.756310198460233 0.223874416248289 no 2639 0.224731617474152 3671 1377751
SGTC_1831 st055328 12 µM -0.758442306488451 0.223247382050765 no 2640 0.22409311953615 3746 1103068
SGTC_724 3910-0327 137 µM -0.758979418654471 0.223089579867182 no 2641 0.223932434311767 3798 2885483
SGTC_1435 4092-0789 56.7 µM -0.759276596879977 0.223002296962609 no 2642 0.2238435570938 3770 2248285
SGTC_691 1548-0686 185 µM -0.759501095030197 0.222936373499986 no 2643 0.223776429632214 3783 46495133
SGTC_732 3970-1727 52.7 µM -0.761109119036552 0.222464504902036 no 2644 0.22329594710096 3787 1275699
SGTC_3339 9145883 14.936 µM -0.761382718278996 0.222384274972477 no 2645 0.223214253293081 3688 2030670
SGTC_3275 9138069 49.47 µM -0.761394812140608 0.222380728963236 no 2646 0.223210642588024 3872 17617007
SGTC_2065 5221596 34.26 µM -0.762134040740006 0.222164042941459 no 2647 0.222990003971048 3758 788581
SGTC_44 0929-0055 61.211 µM -0.762553220138246 0.222041224742176 no 2648 0.222864946106738 3739 1379590
SGTC_547 1120-0019 610 nM -0.762559152674082 0.222039486806705 no 2649 0.222863176482466 3705 3676939
SGTC_481 bay k-8644 50 µM -0.762722940142781 0.221991508359594 no 2650 0.222814323254849 3754 2303 A calcium channel antagonist.
SGTC_2170 morpholine 200 µM -0.762923173307321 0.221932861876167 no 2651 0.222754607584649 3810 121171 Reacts with secondary amines.
SGTC_718 1130-0073 349 µM -0.76370929243369 0.221702700262992 no 2652 0.222520250967165 3822 6740020
SGTC_1571 st070080 73.4 µM -0.764351608601283 0.221514742866873 no 2653 0.222328869078239 3833 4315245
SGTC_1280 0880-0253 10.1 µM -0.766731806023738 0.220819033676927 no 2654 0.221620494492206 3770 6836607
SGTC_713 1488-1073 324 µM -0.768238806718295 0.2203791992443 no 2655 0.221172661113962 3743 3312542
SGTC_3341 9147222 25.867 µM -0.768321867870337 0.220354971560708 no 2656 0.221147993005933 3788 1939759
SGTC_1254 0550-0035 264 µM -0.773649220080958 0.218804255827062 no 2657 0.21956912841334 3863 15121435
SGTC_1583 clindamycin 39.6 µM -0.773874600403871 0.218738789597575 no 2658 0.219502475615866 3767 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_181 1447-1644 8.07 µM -0.774900082095295 0.218441060268292 no 2659 0.21919935181792 3769 534600
SGTC_2320 7373003 200 µM -0.775186589076771 0.218357920083674 no 2660 0.219114705781577 3855 5415828
SGTC_85 0868-0259 160.055 µM -0.77620710894487 0.218061928107716 no 2661 0.218813354660599 3764 83173
SGTC_2491 paeonol 100 µM -0.776614168778736 0.21794392887365 no 2662 0.218693219804745 3685 11092 Increases levels of cortical cytochrome oxidase.
SGTC_827 3253-0474 693 µM -0.777300217429888 0.217745139201678 no 2663 0.218490833400122 3780 5402065
SGTC_655 k060-0012 42 µM -0.777380545407576 0.217721870184459 no 2664 0.218467143461976 3792 5994525
SGTC_2067 5224629 34.075 µM -0.777804346863327 0.21759912919612 no 2665 0.218342182480732 3787 2835000
SGTC_63 0099-0242 26.702 µM -0.777932918643179 0.217561900251756 no 2666 0.218304280286412 3848 3898502 YLR359W ADE13
SGTC_1704 st028805 70.8 µM -0.778165881601516 0.2174944534073 no 2667 0.218235613852174 3821 2876101
SGTC_3158 9100007 49.47 µM -0.778703131084248 0.217338956321825 no 2668 0.21807730563183 3819 19297233
SGTC_2816 7982706 58.44 µM -0.778864943697483 0.21729213518821 no 2669 0.218029638212327 3847 2981853
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.779284401681201 0.217170790451288 no 2670 0.217906100539339 3841 521171
SGTC_2970 9090938 41.86 µM -0.783138723807129 0.216057609987656 no 2671 0.216772826728849 3811 17217104
SGTC_1118 chelidonine 707.474 nM -0.783724337070786 0.215888766648173 no 2672 0.216600939504064 3783 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2715 st079500 56.4 µM -0.784373544195956 0.215701677395018 no 2673 0.216410478608615 3750 28246688
SGTC_876 0720-0963 56.8 µM -0.785522280232999 0.215370863730069 no 2674 0.216073706201657 3807 765861
SGTC_2666 tannic acid 100 µM -0.787581790792979 0.214778502236846 no 2675 0.215470684618875 3818 16134267 A thiamine antagonist.
SGTC_657 3534-0529 86.7 µM -0.788298343307423 0.214572627817869 no 2676 0.215261108245919 3837 1049549
SGTC_2453 5731132 22.18 µM -0.788654994903415 0.214470200165958 no 2677 0.215156839347964 3837 1362040
SGTC_2967 9089538 49.85 µM -0.790150384667504 0.214041045098984 no 2678 0.214719973880916 3865 728216
SGTC_1965 Pectolinarigenin 58.4 µM -0.791159320063206 0.213751777934477 no 2679 0.214425513373581 3805 5320438 An anti-inflammatory.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.7912731658009 0.213719152055376 no 2680 0.214392301938428 3858 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2950 9072895 21.46 µM -0.791403070418513 0.213681927570512 no 2681 0.214354409410951 3757 17332245
SGTC_1358 1509-0022 2.48 µM -0.792541649090139 0.213355826735045 no 2682 0.214022458426245 3858 3258434
SGTC_105 0111-0055 734.78 µM -0.79262641027653 0.213331561853808 no 2683 0.213997758395831 3841 5179370
SGTC_848 0368-0089 85.6 µM -0.793764331296832 0.213005961043636 no 2684 0.213666320579688 3828 762535
SGTC_1997 st073024 93.8 µM -0.794146833984903 0.21289657818697 no 2685 0.213554977703843 3801 686268
SGTC_984 1492-0255 2.91 µM -0.79597601291958 0.21237394817832 no 2686 0.213022988839436 3795 1585198
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.796814660121085 0.212134582148182 no 2687 0.212779339804288 3775 5355888
SGTC_1755 st041960 45.185 µM -0.797000885265072 0.212081451322626 no 2688 0.212725258591331 3877 2257073
SGTC_2799 7812892 81.82 µM -0.798626427385972 0.211618007745577 no 2689 0.212253529546281 3830 20205235
SGTC_702 1488-0190 94 µM -0.799268907836042 0.211434999552623 no 2690 0.212067251736349 3856 949357
SGTC_3338 9144300 39.5675 µM -0.79943804392142 0.211386837176953 no 2691 0.212018229102513 3861 4901274
SGTC_307 1501-1223 22.3 µM -0.800486283853482 0.211088488779054 no 2692 0.211714553662371 3840 2830329
SGTC_131 0141-0277 33.849 µM -0.800916002525767 0.210966254287891 no 2693 0.211590137630227 3782 1547771
SGTC_2140 5586273 200 µM -0.801078497690465 0.210920042969695 no 2694 0.211543101717304 3793 854421
SGTC_2217 6934799 96.0675 µM -0.801544847708229 0.210787452608268 no 2695 0.211408145861838 3762 675606
SGTC_2607 solasodine 47.35 µM -0.801572766080108 0.210779516544231 no 2696 0.211400068234616 3856 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1222 0366-0074 1.18 µM -0.805877037391376 0.209558083913292 no 2697 0.210156876325439 3898 286520
SGTC_1288 0973-0013 65.5 µM -0.806772120737415 0.209304608035322 no 2698 0.209898892051402 3891 4315430
SGTC_1487 3970-0795 2.82 µM -0.807114333849098 0.20920774546919 no 2699 0.20980030731409 3894 3765103
SGTC_2839 9003951 25.97 µM -0.808401253989231 0.208843722230163 no 2700 0.209429815159067 3882 2990634
SGTC_1021 4476-0760 85.3 µM -0.809811905406654 0.208445128937733 no 2701 0.209024144524943 3874 746768
SGTC_1663 st014140 55.4 µM -0.810099001672158 0.208364062072431 no 2702 0.208941639011011 3906 4207120
SGTC_524 r073-0010 27.8 µM -0.810827283786058 0.208158501778625 no 2703 0.208732431905123 3780 2772106
SGTC_1138 3761-0006 1.03 µM -0.810830896303452 0.208157482430738 no 2704 0.208731394477273 3811 12061087
SGTC_2080 5212524 12.4 µM -0.810881496762494 0.208143204754842 no 2705 0.208716863565463 3771 260183
SGTC_859 0439-0102 54.6 µM -0.811538111265438 0.20795798357312 no 2706 0.208528357934229 3818 610143
SGTC_1912 st060209 90.8 µM -0.811980244004621 0.207833319348027 no 2707 0.208401483849646 3879 688787
SGTC_1794 st048918 76.9 µM -0.81447120252625 0.207131791208771 no 2708 0.207687531513096 3749 672303
SGTC_3251 9135047 49.47 µM -0.816685803389114 0.206509271455634 no 2709 0.20705400318218 3858 17682963
SGTC_3294 9122953 26.2835 µM -0.816985114021868 0.206425220953716 no 2710 0.206968467525869 3850 16459826
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.817206352410582 0.206363107231265 no 2711 0.206905256449196 3902 6708561
SGTC_758 0868-0029 16 µM -0.819330942686472 0.20576718256719 no 2712 0.206298811554553 3929 762687
SGTC_128 0906-2981 13.371 µM -0.819771730521512 0.205643674363466 no 2713 0.206173124776005 3782 6740226
SGTC_2442 5158906 48.48 µM -0.821281020411921 0.205221106629815 no 2714 0.20574310800197 3892 1893835
SGTC_2330 7979373 200 µM -0.824173680293319 0.204412669316075 no 2715 0.204920439818895 3820 1863007
SGTC_840 0245-0196 390 µM -0.824790025460269 0.204240659179107 no 2716 0.20474540525867 3966 3827528
SGTC_766 1391-0721 126 µM -0.825174539332199 0.204133392391401 no 2717 0.204636253035825 3908 1020919 YIL115C NUP159
SGTC_1460 k062-0059 9.15 µM -0.825487560083469 0.204046094626962 no 2718 0.20454742118368 3768 1373085
SGTC_57 miconazole 162.5 nM -0.826770995396499 0.203688392398419 no 2719 0.20418343633095 3821 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_320 4092-0846 5.34 µM -0.828173387874409 0.203297963767903 no 2720 0.203786156340843 3846 1359356
SGTC_424 splitomicin 100 mM -0.830418785219694 0.202673771840142 no 2721 0.203151024133763 3979 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_218 alverine citrate 93.75 µM -0.830811120310982 0.202564825332367 no 2722 0.20304016978523 3908 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2714 st079313 56.9 µM -0.831238652842496 0.20244614480707 no 2723 0.202919411528855 3848 2939799
SGTC_233 rapamycin 362 pM -0.831510670418375 0.202370655968345 no 2724 0.202842601421839 3881 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2958 9077254 16.72 µM -0.831752459368175 0.202303570147159 no 2725 0.202774341610913 3922 16457351
SGTC_1905 st060207 84.5 µM -0.832038120718451 0.202224328803608 no 2726 0.20269371380325 3796 1948547
SGTC_2572 astragaloside iv 100 µM -0.833786737693248 0.201739674118209 no 2727 0.202200585039132 3943 45006101 An anti-inflammatory agent.
SGTC_2593 nobiletin 86.24 µM -0.834047337247781 0.201667504759498 no 2728 0.202127154669258 3894 72344 An anti-infammatory.
SGTC_377 3970-0964 33.1 µM -0.836329584246479 0.201036129746568 no 2729 0.201484757162781 3860 16481235
SGTC_2196 6573537 42.6665 µM -0.836952266996726 0.200864073016237 no 2730 0.201309699643297 3902 2903087
SGTC_135 0933-0004 26.348 µM -0.838930893128792 0.200317935258304 no 2731 0.200754045318694 3880 21230617 YGL099W LSG1
SGTC_2755 lomerizine 42.69 µM -0.83992251317111 0.20004456553551 no 2732 0.200475916920306 3885 3949 A calcium channel blocker.
SGTC_1793 st048256 72.231 µM -0.841443664284579 0.199625650901966 no 2733 0.200049716353571 3769 672022
SGTC_74 000s-0487 160.283 µM -0.844263016390312 0.198850617838699 no 2734 0.199261223863513 3810 677548
SGTC_3123 9126162 49.47 µM -0.84440737716729 0.198810982286405 no 2735 0.199220900700587 3973 25239884
SGTC_1795 st049545 62.3 µM -0.844501656093852 0.198785099728531 no 2736 0.199194569161021 3832 5291882
SGTC_1125 tnp00248 1.32998 µM -0.845856215286743 0.198413454544126 no 2737 0.198816480360602 3998 24207736
SGTC_1721 st082152 9.2685 µM -0.846358898202387 0.198275642099938 no 2738 0.198676280069639 3831 5296051
SGTC_3296 9122258 64.045 µM -0.847089889065013 0.198075341282261 no 2739 0.19847251018902 3922 4730474
SGTC_912 3474-0017 2.18 µM -0.849490769345565 0.197418329652619 no 2740 0.197804132182984 3948 3360550
SGTC_2957 9076800 11.52 µM -0.852544584439086 0.196584546340406 no 2741 0.196955952287052 3885 16459615
SGTC_378 3970-0959 8.33 µM -0.854201065819608 0.19613317098072 no 2742 0.196496796376029 3933 6615653
SGTC_3147 9097027 49.47 µM -0.857001556456302 0.195371495024379 no 2743 0.195722012217354 3935 25236841
SGTC_935 2996-0153 430 µM -0.857219357153142 0.195312333110406 no 2744 0.195661833262224 3916 23738523
SGTC_235 0330-0087 5 mM -0.86069476121271 0.194369770977934 no 2745 0.194703089594964 3931 46494818 YHR062C RPP1
SGTC_786 4544-0069 423 µM -0.861166343372282 0.194242087206113 no 2746 0.194573216978743 3939 748821 YLR208W SEC13
SGTC_1221 2958-7315 257 µM -0.86321022016027 0.193689285682123 no 2747 0.194010947758272 3939 4562705
SGTC_725 1497-0963 19 µM -0.86330831476233 0.19366277846175 no 2748 0.193983986916044 3989 3549977
SGTC_2300 7976697 71.57 µM -0.863404393348545 0.193636818155594 no 2749 0.193957582379541 3823 2236109
SGTC_2954 9074818 52.69 µM -0.866262868685075 0.192865432985418 no 2750 0.193173011875956 3934 16648742
SGTC_2472 5377652 49.4 µM -0.866821750405307 0.192714833420218 no 2751 0.193019841398093 4011 1610903
SGTC_1523 st012844 44.7 µM -0.868617791907552 0.19223134819217 no 2752 0.19252810982242 4067 4274103
SGTC_2135 5326629 150.42 µM -0.870231648008559 0.191797539840649 no 2753 0.192086911953766 3902 5020077
SGTC_2287 7945887 168.79 µM -0.87335488737913 0.190959709849728 no 2754 0.191234836042626 3953 1245853
SGTC_1553 gossypol 38.6 µM -0.87402617382732 0.190779926282391 no 2755 0.191051999995477 3799 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1494 4358-1428 177 µM -0.874573893081151 0.190633313385691 no 2756 0.190902898979659 3941 1564571
SGTC_1698 5-fluorocytosine 1.055 µM -0.874597208218796 0.190627073949937 no 2757 0.190896553679807 3971 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1284 0929-0043 16 µM -0.875818172386487 0.190300503160342 no 2758 0.19056444464647 3904 1239883
SGTC_2432 5630864 12.22 µM -0.878414416601555 0.18960722997878 no 2759 0.18985943178069 3991 5714970
SGTC_1014 4130-3005 69.3 µM -0.879237430138575 0.189387786025545 no 2760 0.189636276778408 3957 743608
SGTC_279 1273-0055 2.93 µM -0.879352878975314 0.189357015868255 no 2761 0.189604986453477 3946 2847562
SGTC_209 4077-0173 175.592 µM -0.880316169061856 0.18910039364697 no 2762 0.18934402788277 3915 15993494
SGTC_502 l-744,832 89.3 µM -0.882222127845573 0.188593274309248 no 2763 0.188828349007777 3948 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2254 7938975 95.19 µM -0.882540418532426 0.188508668336013 no 2764 0.1887423162451 4008 2969277
SGTC_2105 5350118 200 µM -0.882608137405828 0.18849067076282 no 2765 0.188724015208379 3946 2133313
SGTC_619 1652-1634 108 µM -0.882660118212505 0.18847685659782 no 2766 0.188709968128827 3918 5400454
SGTC_856 0433-0016 11.3 µM -0.88574699674362 0.187657622620486 no 2767 0.187876938600386 4003 3911780
SGTC_265 mycophenolic acid 32.932 µM -0.88705636425846 0.187310791965045 no 2768 0.187524277701661 4016 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_941 3237-0776 460 µM -0.888565310257977 0.186911588016158 no 2769 0.187118370698202 3997 760008
SGTC_1503 4585-0012 61.3 µM -0.890708525921445 0.186345488547103 no 2770 0.18654277981822 4011 2922052
SGTC_365 0121-0052 13.6 µM -0.891817207666995 0.186053063586839 no 2771 0.186245458426922 4013 3101739
SGTC_2157 5649910 96.377 µM -0.892330272342279 0.185917834419507 no 2772 0.186107966445888 3943 2858091
SGTC_1306 1185-0270 9.02 µM -0.894649757872771 0.185307245323376 no 2773 0.185487172073328 3988 1548076
SGTC_1034 k072-0165 12.7 µM -0.894763570099613 0.185277317094694 no 2774 0.185456744128717 4012 5835461
SGTC_760 0568-0725 82.9 µM -0.895367503876537 0.185118556015404 no 2775 0.185295332975389 3988 3916171
SGTC_2641 levomentholum 100 µM -0.895446579883776 0.185097774908042 no 2776 0.18527420508286 3922 16666
SGTC_549 1661-1316 519 µM -0.895520100595885 0.185078455027568 no 2777 0.185254562821745 3963 2857282
SGTC_204 PMA1.184 62.41 µM -0.897607019620822 0.184530573935326 no 2778 0.184697547677159 3991 2252213 YGL008C PMA1
SGTC_1060 3448-7350 82 µM -0.899134213895083 0.184130277847133 no 2779 0.184290588007514 3929 570178
SGTC_2347 9049783 174.81 µM -0.900016575338235 0.183899246796394 no 2780 0.18405571492664 4021 6467988 YPL169C MEX67
SGTC_2180 6301957 200 µM -0.900910750244913 0.183665306852358 no 2781 0.183817887465498 3971 845462
SGTC_2877 9040724 71.43 µM -0.902804628720509 0.183170430477674 no 2782 0.18331479705237 3949 6463895
SGTC_236 1509-0011 5.31 µM -0.904309317807109 0.182777843987918 no 2783 0.182915703675652 4027 3107280
SGTC_1791 st048313 56.1 µM -0.904407073348968 0.182752356899471 no 2784 0.182889794440227 3966 1204976
SGTC_661 1304-0007 33.6 µM -0.905740809429129 0.18240484330232 no 2785 0.182536528410057 3978 3117130
SGTC_1017 4239-0030 168 µM -0.906236711454455 0.182275738166142 no 2786 0.182405287843431 4006 1149593
SGTC_404 fumagillin 50 µM -0.906247677998679 0.18227288373726 no 2787 0.182402386211791 3958 12015870 A methionine aminopeptidase binder.
SGTC_1725 st036284 20.55 µM -0.907946991026205 0.181830915312408 no 2788 0.181953114431806 4084 707914
SGTC_2596 sinensetin 100 µM -0.908012631548813 0.181813856554475 no 2789 0.181935773997356 4008 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2734 clemastine 41.6 µM -0.908627924048798 0.181654002088485 no 2790 0.181773280763194 3998 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2165 5727197 32.143 µM -0.908670600159826 0.18164291799499 no 2791 0.181762013752718 4166 1361712
SGTC_2867 9039098 71.43 µM -0.908937991783466 0.18157347908481 no 2792 0.181691429068675 3944 6463460
SGTC_1024 4507-0395 26 µM -0.911451214271229 0.180921632654934 no 2793 0.181028839741458 4069 4201836
SGTC_2627 acetyl isogambogic acid 100 µM -0.912961810590222 0.180530540713339 no 2794 0.180631313536929 4014 6857789 A caspase activator and apoptosis inducer.
SGTC_1160 4092-0570 10.5 µM -0.914615701966471 0.180102958407724 no 2795 0.180196706307438 3980 4994975
SGTC_420 mitomycin C 81.9 mM -0.915602406120398 0.17984816777438 no 2796 0.179937734443701 3974 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2558 carylophyllene oxide 100 µM -0.917142940486048 0.179450817864965 no 2797 0.179533871069271 4102 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3009 9080819 71.4286 µM -0.917769165797719 0.179289453505564 no 2798 0.179369864105552 4005 17027216
SGTC_27 0485-0001 32.618 µM -0.919229733278873 0.178913452419773 no 2799 0.178987711064882 3912 2054479
SGTC_2081 5214970 32.255 µM -0.919362974294207 0.178879176246871 no 2800 0.178952874477108 3915 2063512
SGTC_1320 1313-0481 95.3 µM -0.920579969958546 0.178566296126381 no 2801 0.178634881838669 3984 6813365 YLR208W SEC13
SGTC_1393 3470-5649 58.2 µM -0.920871621298577 0.178491366062736 no 2802 0.178558728226074 3974 4108395
SGTC_2020 4017018 200 µM -0.92129008046765 0.17838389156594 no 2803 0.178449499310926 4090 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2468 5987765 72.9 µM -0.921431389942727 0.178347607714372 no 2804 0.178412623308144 4038 26772094
SGTC_2474 5321570 43.32 µM -0.923718313650923 0.177761043999403 no 2805 0.177816497286551 4014 2841384
SGTC_700 3453-2283 142 µM -0.924143264077807 0.177652184433554 no 2806 0.177705865225071 4066 565664
SGTC_439 amiodarone 34.4 µM -0.924315367462433 0.177608108674086 no 2807 0.17766107199909 3863 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2568 diosmetin 100 µM -0.924344756637354 0.177600582782155 no 2808 0.177653423611588 4059 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_75 0159-0059 199.013 µM -0.924725204983015 0.177503176874325 no 2809 0.177554432564283 4072 5377270
SGTC_841 0251-0215 91.2 µM -0.927858016097505 0.176702368088443 no 2810 0.176740612463664 4035 3888614
SGTC_2141 5621638 7.665 µM -0.928228024794627 0.176607937566205 no 2811 0.176644650101558 4034 2856238
SGTC_23 0213-0011 39.996 µM -0.929040035264119 0.176400814939649 no 2812 0.176434169369305 4004 627608
SGTC_2881 9058953 51.95 µM -0.93004526672692 0.176144619664513 no 2813 0.176173823816911 3957 17122249
SGTC_2991 9074669 71.4286 µM -0.931244166117223 0.175839373923212 no 2814 0.175863638193077 4000 17333109
SGTC_2026 5148700 152 µM -0.931544292207281 0.175763012794574 no 2815 0.175786042141218 3976 79838
SGTC_1115 galangin 695.678 nM -0.932124241504899 0.175615515729242 no 2816 0.175636160699006 4056 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1023 4482-3888 16 µM -0.933475309865515 0.175272206170543 no 2817 0.175287306285166 4039 3303168
SGTC_366 0181-0206 4.31 µM -0.933889443810817 0.175167059064203 no 2818 0.175180462316189 4021 274874
SGTC_2448 5185112 27.17 µM -0.934477228161616 0.175017891454636 no 2819 0.175028888560512 4046 5718189
SGTC_301 4119-0100 24.5 µM -0.934605831234582 0.174985265381815 no 2820 0.174995736388395 4033 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1821 st053465 65.6 µM -0.934906364667842 0.174909036328427 no 2821 0.174918278377738 4010 675086
SGTC_2549 cedrol 20.94 µM -0.934915580777139 0.174906699033774 no 2822 0.174915903406881 3952 6708665 A sedative which affects the nervous system.
SGTC_2688 kanamycin b 96.69 µM -0.935039630465294 0.174875240759286 no 2823 0.174883938069737 4090 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_526 4469-0568 170 µM -0.935416518419111 0.17477968621053 no 2824 0.174786843676741 3950 2901964
SGTC_1732 st034308 51.822 µM -0.936828712564217 0.174421939414478 no 2825 0.1744233366651 3886 830119
SGTC_2493 resveratrol 26.09 µM -0.936863825919785 0.174413050186925 no 2826 0.174414304405584 3887 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1782 st039423 80.636 µM -0.938667575881206 0.173956803553294 no 2827 0.173950722869112 4048 2068169
SGTC_726 3448-4391 34.2 µM -0.939687959143216 0.173699040734686 no 2828 0.173688821597992 4130 1356692
SGTC_350 k064-0020 19.8 µM -0.940928422131372 0.173386010184184 no 2829 0.173370770619665 4035 2790705
SGTC_2541 muurolladie-3-one 83.07 µM -0.941950341964049 0.173128398910099 no 2830 0.173109032166998 4046 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2949 9072542 2.23 µM -0.944437958736929 0.172502326151402 no 2831 0.172472945866013 4101 16457352
SGTC_3152 9099253 49.47 µM -0.944816381197003 0.172407213088494 no 2832 0.172376313628054 3951 25236131
SGTC_1475 4092-1048 11.7 µM -0.945487439244025 0.172238630990429 no 2833 0.172205040240144 4048 2881759
SGTC_1740 st038286 13.222 µM -0.947166729237315 0.171817223653691 no 2834 0.171776913043709 4091 716786
SGTC_1994 st072947 40.9 µM -0.947440857797703 0.171748495372188 no 2835 0.171707089837429 4087 5286565 YDL195W SEC31
SGTC_963 1269-2853 151 µM -0.947923231326278 0.171627599489745 no 2836 0.171584268641452 4016 3668223
SGTC_1448 4255-0083 152 µM -0.950581992077539 0.170962218003353 no 2837 0.170908306826641 4113 5399660
SGTC_3244 9134489 49.47 µM -0.95274291645152 0.170422642456569 no 2838 0.170360171559102 4046 16584271
SGTC_1799 st045822 46.1415 µM -0.953054244030153 0.170344994990504 no 2839 0.170281293801679 4000 3674992
SGTC_1784 st039334 36.3 µM -0.953480407912932 0.170238743223942 no 2840 0.170173359131066 4118 3496984
SGTC_2103 5378138 10 µM -0.953596734539515 0.170209747887683 no 2841 0.170143904665107 4081 244142
SGTC_1815 st051655 58.2 µM -0.953776448289107 0.170164959027979 no 2842 0.170098406694889 3985 5984156
SGTC_705 1124-0212 310 µM -0.95452174447323 0.169979294441069 no 2843 0.169909803951227 3987 9554485
SGTC_3084 9116877 49.47 µM -0.954788733357839 0.169912815062957 no 2844 0.169842273057313 3949 27241325
SGTC_1451 4152-0210 104 µM -0.959505031732731 0.168741220599068 no 2845 0.168652193022519 4065 659563
SGTC_2492 derrusnin 100 µM -0.960117782208356 0.16858938677523 no 2846 0.168497969916296 3996 1715307 Part of coumarin class of compounds.
SGTC_1244 0416-0015 52.5 µM -0.961962049926944 0.168132924681447 no 2847 0.168034333725545 4011 96201
SGTC_633 0437-0093 97.7 µM -0.961975748238221 0.168129537283954 no 2848 0.168030893139061 3992 2831118
SGTC_2352 9027995 87.8 µM -0.965572125041339 0.167241723765285 no 2849 0.167129164616451 3999 2997347
SGTC_2753 fluvastatin 17.09 µM -0.966471846607528 0.167020088939679 no 2850 0.166904063981074 4086 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2408 sulbentine 18.36 µM -0.968138930833082 0.166609925068473 no 2851 0.166487494608506 4031 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3092 9117248 49.47 µM -0.968318505374374 0.166565781961907 no 2852 0.166442662775961 4132 17141857
SGTC_1059 3448-6867 171 µM -0.96903327260775 0.166390152343724 no 2853 0.166264294225403 3971 3934407
SGTC_682 0kpi-0099 17 µM -0.970602914607515 0.166004886247732 no 2854 0.165873027010726 4089 1714895 YML126C ERG13
SGTC_3070 9117005 49.47 µM -0.974247299474056 0.165112602678895 no 2855 0.164966882305936 4131 8779016
SGTC_3110 9122132 49.47 µM -0.976359481150166 0.164596884340275 no 2856 0.164443176667292 4165 918317
SGTC_1349 flufenamic acid 69 µM -0.976741989666398 0.164503601354387 no 2857 0.164348450837699 3984 3371 A non-steroidal anti-inflammatory.
SGTC_1052 3253-3998 198 µM -0.977264799765536 0.164376158221976 no 2858 0.164219037435495 3996 5450317
SGTC_586 0957-0265 8.15 µM -0.978094733955123 0.164173980283188 no 2859 0.164013736062807 3947 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1174 0739-0097 51.1 µM -0.978251082367844 0.164135910746072 no 2860 0.163975078699113 4098 728447
SGTC_1308 1187-1617 41.4 µM -0.979203475439041 0.163904134641954 no 2861 0.1637397258764 4072 2882570
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.979471235584496 0.16383901031482 no 2862 0.163673597216367 4132 688664
SGTC_690 glyoxal 20.3 µM -0.979521532262689 0.163826779086027 no 2863 0.163661177392205 3869 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2015 5119600 184 µM -0.980254078275115 0.163648704516115 no 2864 0.163480358205232 4106 2828786
SGTC_3202 9113761 49.47 µM -0.980587934428002 0.163567589145302 no 2865 0.163397993335155 4085 4798415
SGTC_2286 7945697 125 µM -0.981294209714117 0.163396074999732 no 2866 0.163223838657261 4100 1245733
SGTC_2055 5235184 200 µM -0.982352996580475 0.163139174732777 no 2867 0.162962987037951 4138 2836034
SGTC_65 0798-0905 34.986 µM -0.984915660705902 0.162518466247683 no 2868 0.162332750073943 4186 3602145
SGTC_1954 st077032 68.9 µM -0.986588981398819 0.162113997989984 no 2869 0.161922087038049 4055 698907
SGTC_2765 myclobutanil 7.74 µM -0.989145853204099 0.161497228592202 no 2870 0.161295893003533 4115 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2260 7964312 200 µM -0.991279636506394 0.160983689453606 no 2871 0.160774526787618 4150 231951
SGTC_1884 5633444 25 µM -0.991643808036781 0.16089615062378 no 2872 0.160685655573686 4087 5724239
SGTC_836 0330-0104 1.35 µM -0.991765377005967 0.160866935035496 no 2873 0.160655995428944 4094 46494820
SGTC_278 4092-0821 23.9 µM -0.993941467163779 0.160344560530455 no 2874 0.160125682351105 4082 877900
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.998589648238084 0.159232473000316 no 2875 0.158996758420062 4083 676296 Flavone; oxidizing agent.
SGTC_1106 tegaserod maleate 11.7 µM -0.999439378639875 0.159029720585996 no 2876 0.158790945913398 4094 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_535 2293-4129 48.2 µM -1.00018899972096 0.158850995543405 no 2877 0.158609525853748 4096 396118 YIL048W NEO1
SGTC_1276 0871-0068 94.2 µM -1.00202762838342 0.158413186418308 no 2878 0.158165124626445 4099 3414906
SGTC_2865 9030313 51.95 µM -1.00471704561938 0.157774216946096 no 2879 0.157516558962519 4048 42562754
SGTC_1939 st074455 53.6 µM -1.00858643348373 0.156857876209786 no 2880 0.15658650815939 4122 1644229
SGTC_2511 berberine 10.47 µM -1.01272827075405 0.155880902656278 no 2881 0.155594985209931 4083 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3074 9116018 49.47 µM -1.01371785666082 0.1556480748524 no 2882 0.155358700480346 4164 17027303
SGTC_1509 1326-1131 80 µM -1.02085440006707 0.153975797518462 no 2883 0.153661713100182 4073 768313
SGTC_2683 piperine 63.03 µM -1.02106379813273 0.153926910320427 no 2884 0.153612106703701 4092 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3008 9078912 71.4286 µM -1.02326392769997 0.153413877218166 no 2885 0.153091537140334 4101 16648731
SGTC_2311 7694451 200 µM -1.02356533414117 0.153343682635686 no 2886 0.153020312960122 4096 2163142
SGTC_1416 3966-0321 25.3 µM -1.02372550315799 0.153306389513306 no 2887 0.152982472984192 4148 582530 YLR208W SEC13
SGTC_107 0358-0022 2.6945 µM -1.02687887908492 0.152573393682437 no 2888 0.152238750412906 4153 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1889 st059080 5.18 µM -1.02737043173131 0.152459343099431 no 2889 0.152123034520207 4077 176925 Isolated from Daphnopsis sellowiana.
SGTC_84 0443-0269 128.823 µM -1.02891307726677 0.152101784274208 no 2890 0.151760261322065 4026 6150058
SGTC_1826 st055655 41.6 µM -1.03041835763789 0.151753423295986 no 2891 0.151406829648696 4146 676168
SGTC_2483 5729050 27.16 µM -1.03175665021921 0.151444153212862 no 2892 0.151093065796921 4147 2865180
SGTC_2942 9052777 62.25 µM -1.03510755764802 0.150671621467429 no 2893 0.150309341728943 4193 6469503
SGTC_570 0987-0065 62.6 µM -1.03603388139421 0.150458526852 no 2894 0.15009316810415 3903 3104428
SGTC_2911 7942208 15.64 µM -1.03631196271971 0.15039459529541 no 2895 0.150028313499458 4160 1243384
SGTC_245 methotrexate 289.6 µM -1.03669528163793 0.150306499040634 no 2896 0.149938945835577 4104 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_286 k060-0067 22.9 µM -1.03792909783406 0.150023170807324 no 2897 0.149651532772316 4133 5985051
SGTC_2905 7799065 20.05 µM -1.03850134479857 0.149891883437257 no 2898 0.149518354756335 4046 1296806
SGTC_1856 st057054 55.7 µM -1.03864842117326 0.149858152921277 no 2899 0.149484138714942 4142 1266018
SGTC_1208 2323-2347 50.3 µM -1.0422309295318 0.149038103450855 no 2900 0.148652313246961 4152 5412760
SGTC_2237 6667747 47.222 µM -1.04243169724441 0.148992235847969 no 2901 0.148605788574398 4139 729940 YDL015C TSC13
SGTC_1871 st057448 67.3 µM -1.04247058569925 0.148983352441017 no 2902 0.148596777929079 4195 691747
SGTC_2690 usnic acid 100 µM -1.04300772635623 0.148860687979851 no 2903 0.1484723571768 4176 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2038 4100038 30.985 µM -1.04319140938323 0.148818756580499 no 2904 0.148429825688389 4120 3596803
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.04355527716211 0.148735715680288 no 2905 0.148345596791369 4101 15053
SGTC_2428 5615643 7.78 µM -1.04842459346027 0.14762743433566 no 2906 0.147221513755485 4182 2253075
SGTC_2379 9035213 200 µM -1.04943400842857 0.147398380289331 no 2907 0.146989206392669 4138 646551
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.04970776632234 0.147336300872081 no 2908 0.146926245986224 4123 140250 A respiratory chain inhibitor.
SGTC_2913 7966556 36.57 µM -1.04996684676482 0.147277565965681 no 2909 0.146866677845222 4010 2976516
SGTC_3025 9087895 49.47 µM -1.05094414052043 0.147056149571503 no 2910 0.146642122910185 4132 17173641
SGTC_861 0443-0273 110 µM -1.05166687872323 0.14689254911317 no 2911 0.146476206038507 4135 6149169
SGTC_2252 omeprazole 400 µM -1.054789398858 0.146187132722258 no 2912 0.145760827057749 4110 4594 A proton pump inhibitor.
SGTC_787 4152-0075 138 µM -1.05488037342692 0.146166614596046 no 2913 0.145740019773007 4162 9566539
SGTC_1394 3474-0001 65.7 µM -1.05508140255107 0.146121281961729 no 2914 0.14569404839784 4151 5017666 YIL048W NEO1
SGTC_1331 1472-0049 76.2 µM -1.05509477708708 0.14611826630125 no 2915 0.145690990252515 4083 24051409
SGTC_487 nimodipine 119 µM -1.05679633222458 0.145734944433759 no 2916 0.14530227430217 4094 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1672 st016598 6.51 µM -1.06030594994458 0.144946443729624 no 2917 0.144502716627291 4157 4665860 YNL267W PIK1
SGTC_3089 9117425 49.47 µM -1.06104315839098 0.144781181876772 no 2918 0.144335143992498 4158 9401657
SGTC_2961 9083290 32.55 µM -1.06379456126578 0.144165513921964 no 2919 0.14371088783845 4095 17741490
SGTC_1051 3253-3903 78 µM -1.06510904560798 0.143872002190175 no 2920 0.143413293169908 4143 5509239
SGTC_2872 9044037 25.97 µM -1.06748740125329 0.143341963384706 no 2921 0.142875899900907 4166 6465195
SGTC_2396 5342950 42.78 µM -1.06757262929076 0.143322994023564 no 2922 0.142856667781673 4144 1886677
SGTC_2564 betulinic acid 100 µM -1.07042695356327 0.142688680814255 no 2923 0.142213586163122 4231 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3331 9141060 1.957 µM -1.07101712835772 0.14255776410479 no 2924 0.142080864074976 4122 4906567 YPR165W RHO1
SGTC_2947 9072639 7.68 µM -1.07198986281067 0.142342162658143 no 2925 0.141862292675705 4169 16488146
SGTC_3303 9125618 40.5795 µM -1.07291918918797 0.14213638853662 no 2926 0.141653687758388 4180 22695467
SGTC_1882 5615643 20 µM -1.07619430564175 0.141412808414406 no 2927 0.140920182959466 4126 2253075
SGTC_1714 st033236 13.627 µM -1.07893705933509 0.140808768534792 no 2928 0.140307893398441 4218 2916566
SGTC_942 3253-1115 227 µM -1.08069180299962 0.140423238838368 no 2929 0.139917115270833 4228 46497897
SGTC_1720 st037298 9.481 µM -1.08294029845497 0.139930276832337 no 2930 0.139417461648069 4181 597396
SGTC_1225 1216-0074 20.6 µM -1.09000675633488 0.138388683661245 no 2931 0.137855083949578 4199 4241466
SGTC_443 clozapine 122 µM -1.09057355106686 0.138265537158073 no 2932 0.137730286455885 4134 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2523 spermine 47.74 µM -1.09295661855324 0.137748589735156 no 2933 0.137206423660778 4211 1103 A DNA binding polyamine.
SGTC_1407 3909-7909 12.3 µM -1.09413039086382 0.13749445432013 no 2934 0.136948897626759 4182 4411780
SGTC_1617 st002906 78 µM -1.09526670856993 0.137248733375872 no 2935 0.136699904012362 4174 5150859
SGTC_1472 k841-0093 193 µM -1.09532242045657 0.137236693778842 no 2936 0.136687704208142 4295 X1472
SGTC_2699 st077704 54.6 µM -1.09687274355326 0.13690195108883 no 2937 0.136348512597784 4198 645852
SGTC_2399 5884133 200 µM -1.09790553053575 0.136679263717488 no 2938 0.136122871369552 4184 722445
SGTC_993 3909-8757 62.7 µM -1.09867924103046 0.13651260023101 no 2939 0.13595400019299 4129 4288324 YLR208W SEC13
SGTC_742 0kpi-0133 140 µM -1.10016452061572 0.136193048675928 no 2940 0.135630223015184 4224 2728852
SGTC_198 3454-2873 16.191 µM -1.10095464092498 0.13602326642048 no 2941 0.13545819953143 4179 710957
SGTC_763 3453-1109 128 µM -1.10097948664536 0.136017929885014 no 2942 0.135452792594484 4208 1560353
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.10132875710268 0.135942926332299 no 2943 0.135376799852219 4077 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1237 0330-0133 46.1 µM -1.10298479006109 0.135587689518188 no 2944 0.135016885190801 4137 X1237 YHR072W ERG7
SGTC_1970 st070122 35.8 µM -1.10333178399727 0.135513336264556 no 2945 0.134941554346518 4218 102928
SGTC_2658 polymyxin b sulfate 77.05 µM -1.10476505769325 0.135206512951439 no 2946 0.13463070249642 4229 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2034 5197015 53.07 µM -1.10692497604309 0.134745035888265 no 2947 0.134163183207116 4207 780676
SGTC_1906 st060206 94.7 µM -1.10901084393084 0.134300407023656 no 2948 0.133712751999085 4221 5133468
SGTC_3349 9149703 23.001 µM -1.1127301284902 0.133510097311148 no 2949 0.132912175902577 4218 4910494
SGTC_1473 k844-0725 134 µM -1.11306176380165 0.133439783856175 no 2950 0.132840951985211 4249 54682906
SGTC_1762 st045503 25.4615 µM -1.11311384644513 0.133428743587349 no 2951 0.132829768803794 4291 4645554
SGTC_2413 inermin 26.06 µM -1.11377939106961 0.133287719433076 no 2952 0.132686920182892 4283 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_292 k038-0015 474 µM -1.1141296749911 0.133213537976514 no 2953 0.132611779799154 4209 46368540
SGTC_922 1866-0035 480 µM -1.11814895905603 0.132364386244117 no 2954 0.131751689642414 4132 3156169
SGTC_952 1185-0122 232 µM -1.11976091423843 0.132024879794161 no 2955 0.131407829662576 4164 678600
SGTC_2106 5357045 167.29 µM -1.12150205441251 0.131658839879401 no 2956 0.131037108762961 4228 668842
SGTC_417 st075190 100 µM -1.12338006220721 0.131264812036554 no 2957 0.130638056916046 4219 222757
SGTC_1234 0326-0494 15.5 µM -1.12352205069472 0.131235054351698 no 2958 0.130607920438721 4295 1547813
SGTC_415 dibenzyl ketone 100 µM -1.12505612433797 0.130913843118232 no 2959 0.130282626075743 4193 7593
SGTC_807 1315-0151 48 µM -1.12597665178216 0.130721359968129 no 2960 0.130087701104634 4248 4011080
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.13422661907 0.12900501678048 no 2961 0.128349750449415 4269 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3151 9099821 49.47 µM -1.13467969238187 0.128911213104187 no 2962 0.128254774524576 4194 17174189
SGTC_2324 6149169 200 µM -1.13556831884116 0.128727370511524 no 2963 0.128068637110061 4129 2888231
SGTC_2832 7992762 51.95 µM -1.13561730733362 0.128717240869559 no 2964 0.128058381125744 4167 2985177
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.14030180623928 0.127751153251282 no 2965 0.127080292787042 4258 5282362
SGTC_645 0845-0943 5.41 µM -1.14040852019373 0.127729204423235 no 2966 0.127058072438951 4242 1885106
SGTC_2521 angolensin 13.4 µM -1.14189603128061 0.127423527405894 no 2967 0.126748619251905 4274 821428 A flavenoid.
SGTC_806 3966-4455 5.86 µM -1.1448885214106 0.126810125934792 no 2968 0.126127669743413 4215 714982
SGTC_2826 7992541 19.48 µM -1.1453614266188 0.126713378125222 no 2969 0.126029735053255 4249 2985066
SGTC_492 tmb-8 126 µM -1.14563385056227 0.126657668477316 no 2970 0.125973342420991 4195 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_946 3434-1334 87.4 µM -1.14623275503465 0.126535254793959 no 2971 0.125849429135411 4221 4047976
SGTC_1822 st052468 42 µM -1.14770114900466 0.126235469743405 no 2972 0.125545978348424 4231 2873678
SGTC_325 2810-4341 181 µM -1.15126206324257 0.125510535828023 no 2973 0.124812219629014 4232 774970
SGTC_273 hydroxyurea 18.1 mM -1.15576295679339 0.124598403940503 no 2974 0.123889064386881 4320 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_129 0088-0017 176.636 µM -1.15642562623222 0.12446450251517 no 2975 0.123753552312062 4125 182446
SGTC_1667 st014849 34.6 µM -1.15668336106123 0.124412450853186 no 2976 0.123700875066928 4306 5348460
SGTC_2191 5911152 200 µM -1.15727738449479 0.124292540926604 no 2977 0.123579525125524 4250 2875902
SGTC_1240 0356-0016 42.1 µM -1.1620328396776 0.123335515322707 no 2978 0.122611062879883 4226 4305613
SGTC_406 estrone 100 µM -1.16406855919181 0.122927413129335 no 2979 0.122198114470674 4240 5870 A steroid.
SGTC_550 4123-0385 25.7 µM -1.1652496271251 0.122691078035174 no 2980 0.121958981341602 4283 5731123
SGTC_1655 st012546 55.1 µM -1.16634619677658 0.122471936783506 no 2981 0.121737251172854 4232 720985 YLR208W SEC13
SGTC_3048 9093155 49.47 µM -1.16858301890084 0.122025776513283 no 2982 0.121285836585255 4238 25236002
SGTC_3016 9080866 49.47 µM -1.16929013690938 0.12188497132931 no 2983 0.12114337780745 4229 17066299
SGTC_3035 9091303 49.47 µM -1.17064182954619 0.121616132635366 no 2984 0.120871388110957 4329 25237002
SGTC_358 0075-0058 9.45 µM -1.17173475682808 0.121399064803945 no 2985 0.120651782023161 4135 1069125
SGTC_2275 7947463 200 µM -1.17181743913292 0.121382654244855 no 2986 0.120635179785816 4220 1225414
SGTC_832 4083-0019 164 µM -1.17466226524744 0.120818970711971 no 2987 0.120064930879429 4342 1990758
SGTC_2858 9025781 8.96 µM -1.17527882116298 0.120697047528383 no 2988 0.119941592380294 4150 4894980 YPL153C RAD53
SGTC_1109 tnp00067 928.257 nM -1.17581799687544 0.120590497198644 no 2989 0.119833806576953 4264 676295
SGTC_1529 apigenin 74 µM -1.17708774537948 0.120339834890878 no 2990 0.119580242909506 4288 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3191 9110352 49.47 µM -1.17864470722701 0.120032974750984 no 2991 0.119269840748564 4214 17122424
SGTC_1634 st006576 41 µM -1.17945408677206 0.119873672946628 no 2992 0.119108704431345 4241 3915356
SGTC_1481 3346-2004 36 µM -1.18421632944921 0.118939388401248 no 2993 0.118163719861591 4345 2770522
SGTC_3173 9105693 49.47 µM -1.18505830003253 0.118774742112627 no 2994 0.11799719847121 4280 17096658
SGTC_456 gingerol 170 µM -1.18864568061067 0.118075038896716 no 2995 0.11728956204915 4324 442793 A herb.
SGTC_2400 5203494 178.7 µM -1.19248860044527 0.117328733645101 no 2996 0.116534858972564 4187 6777674
SGTC_530 4358-1714 28 µM -1.19318099992849 0.117194623798602 no 2997 0.116399247073629 4274 1564641
SGTC_3282 9108498 15.4605 µM -1.19350887853644 0.117131155369621 no 2998 0.116335068536712 4246 16459645
SGTC_296 1222-0039 74.9 µM -1.19512023043868 0.116819595149059 no 2999 0.116020029460732 4286 5984176
SGTC_2323 6148992 148.28 µM -1.19770494956194 0.116321058916782 no 3000 0.115515950880645 4255 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2076 5212012 200 µM -1.20129209047591 0.115631681241721 no 3001 0.114818958754664 4246 604802
SGTC_1836 st055642 81 µM -1.2030369324139 0.115297408311146 no 3002 0.114481014478807 4288 8571
SGTC_280 3448-3607 3.04 µM -1.20427971126465 0.115059738726297 no 3003 0.114240742872173 4247 626179
SGTC_3192 9110362 49.47 µM -1.20690134724195 0.114559518986462 no 3004 0.113735069396879 4309 16649480
SGTC_2077 5212015 200 µM -1.21551457707595 0.112926978508026 no 3005 0.112084946248303 4188 780900
SGTC_12 0849-0099 9.267 µM -1.21556693153548 0.112917106351413 no 3006 0.112074968784553 4218 6071388
SGTC_1824 st053723 68.6 µM -1.21780306491625 0.112496027436762 no 3007 0.111649409674071 4306 675225
SGTC_593 1203-0218 61.7 µM -1.21894251200286 0.112281893842958 no 3008 0.111433006377801 4332 3666956
SGTC_683 panaxydol 45 µM -1.22014140331623 0.112056903673107 no 3009 0.111205637728504 4303 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3122 9126309 49.47 µM -1.22036505504828 0.112014967723413 no 3010 0.111163259168654 4364 17591206
SGTC_1123 mangostin 811.285 nM -1.22085469580484 0.111923196520838 no 3011 0.111070520158083 4302 5281650 An antioxidant.
SGTC_154 3389-1638 511.116 µM -1.22089862200735 0.111914966255585 no 3012 0.111062203150134 4309 5238686
SGTC_1171 0368-0077 21.4 µM -1.2263014350788 0.110905962213096 no 3013 0.110042630760367 4261 3239779
SGTC_620 0109-0052 432 µM -1.2271246665658 0.110752793307408 no 3014 0.109887869068832 4336 493037
SGTC_2361 9034121 116 µM -1.22755956525581 0.11067193809 no 3015 0.109806174277726 4322 6496917
SGTC_425 3825-7017 13.1 µM -1.23129753942157 0.109978727762558 no 3016 0.109105800921653 4359 3397440
SGTC_1015 4130-4525 82 µM -1.23156938058541 0.109928436399626 no 3017 0.109054992342341 4311 1363237
SGTC_480 am 92016 50 µM -1.23508247799748 0.109279988000961 no 3018 0.108399904922759 4324 2129 K+ channel blocker.
SGTC_1204 4049-0315 18.3 µM -1.23631188367636 0.109053714384131 no 3019 0.108171327751685 4363 588402
SGTC_2643 anethole 100 µM -1.23750646354476 0.108834173248158 no 3020 0.107949558114137 4307 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1490 4089-0339 670 nM -1.24047230374114 0.10829048233298 no 3021 0.107400376080714 4294 742542
SGTC_503 tyrphostin 8 294 µM -1.24077928540984 0.108234318999064 no 3022 0.10734364777401 4339 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_215 1287-0124 461.5 µM -1.24099734349041 0.108194437273479 no 3023 0.107303365117558 4329 5560863
SGTC_3101 9120531 49.47 µM -1.24113277357028 0.108169673118942 no 3024 0.107278352116829 4314 24824904
SGTC_1304 1165-0502 251 µM -1.2427554556166 0.107873273820311 no 3025 0.106978980826165 4302 767425
SGTC_1211 1056-0033 32.3 µM -1.24400906932193 0.107644689424641 no 3026 0.106748112530105 4379 6741922
SGTC_3106 9121286 49.47 µM -1.24621414874244 0.107243461624669 no 3027 0.106342893018428 4287 15943471
SGTC_1005 4092-0690 4.4 µM -1.2480810836205 0.106904605159788 no 3028 0.106000682457928 4342 1529343
SGTC_1552 6-methylflavone 10.6 µM -1.25060797003793 0.10644719598175 no 3029 0.105538770686719 4277 689013
SGTC_699 0375-0592 111 µM -1.25855398090804 0.105018045596468 no 3030 0.104095738925391 4404 762578
SGTC_80 0159-0065 512.242 µM -1.25901762054469 0.104935087407241 no 3031 0.104011983727654 4260 1548079
SGTC_352 k048-0007 5.11 µM -1.26139676503949 0.104510137734537 no 3032 0.103582966632405 4279 6811911
SGTC_1141 3253-0389 52.6 µM -1.26216265243279 0.104373604791445 no 3033 0.103445132280261 4325 5402031
SGTC_3171 9103192 49.47 µM -1.26544198668012 0.103790467131425 no 3034 0.102856466085802 4415 13018434
SGTC_1216 1165-0504 9.65 µM -1.2656146905665 0.103759822228869 no 3035 0.102825531990971 4346 6304004
SGTC_1346 1488-2224 62.4 µM -1.26570953662649 0.103742995358019 no 3036 0.102808546384109 4350 3722427
SGTC_2265 7929201 200 µM -1.26782892444683 0.103367505824873 no 3037 0.102429525237159 4320 1265108
SGTC_782 0083-0095 30.5 µM -1.27077667194733 0.102846898532523 no 3038 0.101904055032425 4302 3591729 An indicator and reagent.
SGTC_3310 9130229 44.1445 µM -1.27140976764827 0.102735335259487 no 3039 0.101791454765371 4366 7761258
SGTC_1085 doxorubicin 7.67 µM -1.27155592583276 0.102709591961339 no 3040 0.10176547243663 4362 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2518 prenyletin 46.28 µM -1.27316249109522 0.102426931539385 no 3041 0.101480193805032 4348 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2062 5245942 200 µM -1.27358411027247 0.102352845299972 no 3042 0.101405423248892 4382 1376160
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.27441220248201 0.102207447728926 no 3043 0.101258685005001 4384 23665772 A membrane-active detergent.
SGTC_1607 st000305 50.6 µM -1.27755588578586 0.101656843352831 no 3044 0.100703031724698 4347 5457690
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.27800511111467 0.101578339912348 no 3045 0.100623812058485 4341 5379071
SGTC_2232 chlorophetanol 41.5365 µM -1.28080960006653 0.101089245207965 no 3046 0.100130275619382 4417 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1758 st042942 75.2445 µM -1.28742918311376 0.0999416208418146 no 3047 0.0989723690074584 4328 669317
SGTC_468 gf-109203x 121 µM -1.28895591825962 0.0996782893150123 no 3048 0.0987067060708047 4393 2396 A protein kinase C inhibitor.
SGTC_2385 9074692 200 µM -1.29022725216506 0.0994593965633739 no 3049 0.0984858833457348 4374 17046906
SGTC_877 0771-0151 33.1 µM -1.29095138156998 0.0993348762668616 no 3050 0.0983602684050538 4371 6166523
SGTC_1759 st043059 70 µM -1.29233495251148 0.0990972763032142 no 3051 0.09812058628171 4364 669426
SGTC_962 1254-0300 21.5 µM -1.29385150978798 0.0988373164675183 no 3052 0.0978583582240374 4331 7340576
SGTC_3051 9093778 49.47 µM -1.29489188993802 0.09865926907626 no 3053 0.097678763298221 4443 17217378
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.29558062764997 0.0985415298877462 no 3054 0.0975600034328385 4357 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1131 3454-3128 32.3 µM -1.29632666824431 0.0984141109113321 no 3055 0.0974314822717563 4378 710982
SGTC_2455 5377712 9.75 µM -1.29650306536438 0.0983840010513786 no 3056 0.0974011123248279 4360 2243908
SGTC_1811 st050069 61.5 µM -1.29994191293361 0.0977983588157597 no 3057 0.0968104392602383 4347 3877702
SGTC_880 0833-0487 87.2 µM -1.30165190308607 0.0975080973675917 no 3058 0.0965177041487216 4365 76075
SGTC_2317 5986382 200 µM -1.3026369324884 0.09734118110311 no 3059 0.0963493713535945 4391 877883
SGTC_1437 4092-1038 11.6 µM -1.30389941951194 0.0971275554211014 no 3060 0.0961339391140103 4429 3977136
SGTC_21 0849-0113 22.993 µM -1.30628553097861 0.0967247410793019 no 3061 0.095727737847257 4334 1560156
SGTC_1789 tunicamycin 25 nM -1.30675236198516 0.0966460761364295 no 3062 0.0956484144671507 4257 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_97 0535-0701 19.132 µM -1.31196347101911 0.0957711486543686 no 3063 0.0947662300032458 4265 2832013 YGL099W LSG1
SGTC_1688 st021091 57.6 µM -1.31240552223996 0.0956971987325017 no 3064 0.0946916723156627 4382 3656366
SGTC_2908 7930301 100 µM -1.31930316501625 0.0945487419580817 no 3065 0.0935338900715677 4334 2223178
SGTC_195 4234-0266 16.654 µM -1.32013997076535 0.0944101079510091 no 3066 0.0933941448465139 4395 2303354
SGTC_3087 9117406 49.47 µM -1.32180182578474 0.0941352321734248 no 3067 0.0931170751090018 4401 42546093
SGTC_1909 st060837 51.5 µM -1.32315829701289 0.0939113057896197 no 3068 0.0928913705937132 4336 678937
SGTC_2327 6189656 200 µM -1.32701337990955 0.093277055006974 no 3069 0.0922521283474688 4449 5349088
SGTC_2220 6782180 200 µM -1.32822896710979 0.0930777204441229 no 3070 0.0920512388375597 4312 833803
SGTC_1624 st003710 6.25 µM -1.32909382906803 0.0929360903580203 no 3071 0.091908507965481 4424 24207033
SGTC_2712 st079126 47.7 µM -1.32912755689295 0.0929305703075984 no 3072 0.091902945079629 4377 3152970
SGTC_2332 7982454 138.89 µM -1.33106326687971 0.0926141691591878 no 3073 0.0915840971941895 4304 2981748
SGTC_2101 5377231 179.231 µM -1.332859460783 0.09232128600614 no 3074 0.0912889641533722 4417 2844213
SGTC_868 0527-0199 213 µM -1.33385693600743 0.092158936356371 no 3075 0.091125373585778 4353 2849450
SGTC_3309 9129340 25.759 µM -1.33454740567082 0.092046678960255 no 3076 0.0910122607571969 4401 17158987
SGTC_398 bronopol 33.3 µM -1.33488422171685 0.0919919557529685 no 3077 0.0909571213175778 4313 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2889 9059656 51.95 µM -1.33926625728091 0.0912821915548274 no 3078 0.0902420046969929 4457 3949838
SGTC_587 k089-0003 57 µM -1.34317730145713 0.0906521506396283 no 3079 0.0896072848502575 4320 9659696
SGTC_2420 aureobasidin a 50 nM -1.34788146707012 0.0898986264252342 no 3080 0.0888482548915458 4468 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_496 calpeptin 138 µM -1.35416345228837 0.0888996355827898 no 3081 0.0878421181096078 4400 73364 A calpain inhibitor.
SGTC_467 ro 31-8220 72.8 µM -1.35426963230625 0.0888828216541878 no 3082 0.0878251854177796 4353 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2677 mitomycin C 100 µM -1.35520467911843 0.0887348563665612 no 3083 0.0876761771621642 4475 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1104 tacrolimus 29.8 µM -1.35542685133037 0.0886997259951141 no 3084 0.0876407997384892 4477 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_663 1486-0733 13.9 µM -1.35930949515047 0.0880874647681336 no 3085 0.0870242682394718 4418 722445 YPR165W RHO1
SGTC_382 3229-0966 23.2 µM -1.36249277767205 0.0875878422106404 no 3086 0.0865212109506575 4452 5722370
SGTC_48 0382-0018 55 µM -1.36277859579621 0.0875430861486683 no 3087 0.0864761494092924 4449 762596
SGTC_2394 5221648 200 µM -1.36402396215077 0.0873482742679327 no 3088 0.0862800120895501 4435 788586
SGTC_3300 9124615 50.48 µM -1.36643055113445 0.0869727303043281 no 3089 0.0859019325450885 4447 24824903
SGTC_2131 toluylene red 5.2905 µM -1.36900136430289 0.0865728932143798 no 3090 0.0854994242233182 4377 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3141 9094609 49.47 µM -1.37084441042042 0.0862870920609284 no 3091 0.0852117317200804 4375 25236309 YDL196W YDL196W
SGTC_2164 5685496 200 µM -1.37471357444267 0.0856893973674348 no 3092 0.0846101305694395 4337 759046
SGTC_2719 novobiocin 32.65 µM -1.3753760489484 0.0855873721960088 no 3093 0.0845074452211918 4472 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2409 alverine citrate 63.97 µM -1.37564297684133 0.085546289367851 no 3094 0.0844660971068776 4463 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1899 st063254 59.6 µM -1.37587594574006 0.0855104452332147 no 3095 0.0844300217721253 4377 3093813
SGTC_168 3970-0862 530.542 µM -1.37666306967435 0.0853894230958909 no 3096 0.0843082208015501 4361 3135186
SGTC_1322 1348-1070 12 µM -1.37801321620617 0.0851821337693543 no 3097 0.0840996038583713 4413 6758089
SGTC_2546 rhodinyl acetate 100 µM -1.37863900976108 0.0850861830537855 no 3098 0.0840030413477749 4367 6708682
SGTC_101 0490-5701 117.494 µM -1.38626375914406 0.0839236051876746 no 3099 0.0828331893853794 4292 4661669
SGTC_982 1491-0518 27.5 µM -1.3873140102482 0.0837644081893544 no 3100 0.0826730164039401 4364 3091256
SGTC_6 0844-0013 19.835 µM -1.38905629135949 0.0835008137757783 no 3101 0.0824078167125263 4547 1584900
SGTC_1687 st020778 55.3625 µM -1.3925579330019 0.0829729271377037 no 3102 0.0818767557027188 4443 4259299
SGTC_76 0433-0009 400.328 µM -1.39300211141928 0.0829061452554408 no 3103 0.0818095760978784 4485 2841569
SGTC_2721 ifenprodil 61.44 µM -1.39614505022638 0.0824347616963741 no 3104 0.0813354099958481 4430 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2802 7925815 54.55 µM -1.39713669428464 0.0822864527226197 no 3105 0.081186234584129 4415 1262923
SGTC_2221 6807166 181.081 µM -1.39722652530971 0.0822730276457501 no 3106 0.0811727312902308 4404 674925
SGTC_2870 9038528 12.99 µM -1.39726805941709 0.0822668210096092 no 3107 0.0811664885050667 4450 6463316
SGTC_38 0929-0051 58.268 µM -1.39732522659291 0.0822582788275634 no 3108 0.0811578965836047 4402 1379719
SGTC_2788 5282734 71.43 µM -1.39756018072922 0.0822231779156752 no 3109 0.0811225914371773 4453 743706
SGTC_3018 9082602 49.47 µM -1.39977949851932 0.0818921798751722 no 3110 0.0807896794578188 4364 17332089
SGTC_1076 itraconazole 331 nM -1.40381448218274 0.0812929600990105 no 3111 0.0801870501552861 4439 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3094 9117742 49.47 µM -1.40579707979845 0.0809997468728809 no 3112 0.0798921947230297 4400 17149698
SGTC_3325 9138760 55.175 µM -1.40642914467081 0.0809064366182634 no 3113 0.0797983654885319 4394 43844959
SGTC_2350 9023895 38.85 µM -1.40927222793567 0.0804877220946594 no 3114 0.0793773437705624 4417 2997209
SGTC_1621 st003705 32.4 µM -1.41330263816148 0.0798969523257384 no 3115 0.0787833793191489 4441 24207032
SGTC_1344 1488-0097 29.1 µM -1.41348363908162 0.0798704987030181 no 3116 0.0787567843118961 4475 747966
SGTC_507 nimesulide 162 µM -1.41571329193694 0.0795451739301141 no 3117 0.0784297325515389 4485 4495 A COX2 inhibitor.
SGTC_2173 5763948 167 µM -1.41881231201128 0.0790946679710346 no 3118 0.0779768711232219 4410 2867177
SGTC_2868 9035608 32.47 µM -1.41908553037785 0.0790550429630154 no 3119 0.0779370409477588 4425 6462614
SGTC_2161 5662504 8.5105 µM -1.42457093453853 0.0782626693387607 no 3120 0.0771406334067564 4412 2859334
SGTC_753 1322-0200 289 µM -1.42461591315987 0.0782561971079215 no 3121 0.0771341287681714 4502 5403907
SGTC_2007 4011539 71.82 µM -1.42610709504888 0.0780418521634436 no 3122 0.076918715544881 4404 45595301
SGTC_1651 st011928 86.1 µM -1.42690781332183 0.0779269395500809 no 3123 0.0768032342113965 4470 720198
SGTC_180 1486-1293 102.781 µM -1.4302689833346 0.0774459719454379 no 3124 0.0763199166274536 4390 4140536
SGTC_1883 5-benzylidenerhodanine 20 µM -1.4302821579128 0.077444091171158 no 3125 0.076318026760481 4435 1273210
SGTC_2438 5259590 200 µM -1.43057934877797 0.077401674062619 no 3126 0.0762754047849992 4460 1201127
SGTC_1219 1469-0211 33.1 µM -1.43491758647152 0.0767844983087682 no 3127 0.0756552918033838 4462 6822282
SGTC_950 1165-0508 94.1 µM -1.43905053410981 0.0762000151421522 no 3128 0.0750681027851495 4439 6148369
SGTC_2339 9000433 200 µM -1.44124274406331 0.0758913694784287 no 3129 0.0747580582540067 4441 2988954
SGTC_1681 tripelennamine 100 µM -1.44214547096128 0.0757645498231086 no 3130 0.0746306698622223 4361 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1350 1495-0454 146 µM -1.44787930053724 0.0749627982368495 no 3131 0.0738254048071846 4492 1069057
SGTC_1062 mesoridazine 14.2 µM -1.45052007114872 0.0745957275039286 no 3132 0.0734567731326341 4512 4078 A neuroleptic.
SGTC_3265 9137266 49.47 µM -1.45143694834623 0.0744686016734664 no 3133 0.0733291137385782 4434 17224265
SGTC_293 4049-0273 38.5 µM -1.4525397174011 0.0743159209401994 no 3134 0.0731757969825978 4334 1380311
SGTC_2109 5483026 200 µM -1.45377798225017 0.0741447655525095 no 3135 0.0730039348536012 4483 759335
SGTC_795 0685-0265 78 µM -1.45697495143196 0.0737042665036144 no 3136 0.0725616473540392 4470 302754
SGTC_2158 5657123 3.6195 µM -1.4593146903522 0.0733831520465451 no 3137 0.0722392569668072 4461 2858827
SGTC_747 3448-8087 38.7 µM -1.46380118244694 0.0727704038422913 no 3138 0.071624139640758 4508 5168703
SGTC_1279 0874-0590 65.2 µM -1.46533074199036 0.0725624002455905 no 3139 0.0714153515239844 4530 3523074
SGTC_523 1934-0222 13.7 µM -1.46616036254061 0.0724497714504474 no 3140 0.0713023021212378 4437 1361595
SGTC_2725 haloperidol 53.21 µM -1.46643666198175 0.0724122909464578 no 3141 0.0712646823021025 4437 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_246 cycloheximide 667 µM -1.47063991084629 0.0718439432391727 no 3142 0.0706942622554964 4400 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2850 9015429 58.44 µM -1.47078305012441 0.071824648885845 no 3143 0.0706748988790963 4470 6457570
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.47117643426385 0.0717716434299096 no 3144 0.07062170425386 4498 390807
SGTC_3343 9148379 18.9835 µM -1.47465693618069 0.0713039790977111 no 3145 0.0701523996336594 4487 1955036
SGTC_791 1348-1292 225 µM -1.47697308878339 0.0709940634558489 no 3146 0.0698414255794463 4444 5437054
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.48006325122657 0.0705821927461571 no 3147 0.0694281837817211 4489 7104
SGTC_178 4092-0806 87.505 µM -1.4851155611112 0.0699127575689484 no 3148 0.0687566073123084 4367 2169044
SGTC_551 k048-0028 34.9 µM -1.4863110757846 0.0697550680389915 no 3149 0.0685984292196342 4454 6836383
SGTC_3027 9089541 49.47 µM -1.48671943164386 0.0697012682828169 no 3150 0.0685444641664528 4478 9943819
SGTC_529 4076-0302 30.3 µM -1.48692245094317 0.069674532941597 no 3151 0.0685176469453892 4445 5816522
SGTC_2363 9053361 176 µM -1.49023164952024 0.0692398612612959 no 3152 0.0680816686235075 4526 6469797 YMR079W SEC14
SGTC_722 3534-0461 190 µM -1.49286463939266 0.0688955061738248 no 3153 0.0677363114385987 4519 658262
SGTC_2565 isoliquiritigenin 100 µM -1.50001419965163 0.0679671115107682 no 3154 0.0668053621837051 4515 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_603 3794-0023 45.9 µM -1.50026691356538 0.0679344733840213 no 3155 0.0667726381855083 4534 3802260
SGTC_3337 9144342 33.5465 µM -1.50084954977776 0.067859271746703 no 3156 0.0666972397157156 4485 17682949
SGTC_1364 1653-0028 37.6 µM -1.50139825720848 0.0677885081418005 no 3157 0.0666262922004493 4494 5718652
SGTC_335 4077-0256 27.6 µM -1.50322088628304 0.0675538633280632 no 3158 0.0663910466415027 4431 3121989
SGTC_3102 9121669 49.47 µM -1.50341655192568 0.0675287107315715 no 3159 0.0663658304784265 4532 41905072
SGTC_452 diindolylmethane 8 µM -1.50349834885613 0.0675181979741856 no 3160 0.0663552912005044 4497 3071 Inhibits expression of several cancer promoting factors.
SGTC_716 1683-5115 658 µM -1.50573765875082 0.0672308869253971 no 3161 0.0660672662595745 4493 723597
SGTC_2533 agelasine 13.65 µM -1.50736961207893 0.0670220979100158 no 3162 0.0658579717039845 4530 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_327 1273-0057 3.96 µM -1.51663518616308 0.0658461713309605 no 3163 0.0646794082788233 4410 3108138
SGTC_513 4245-1575 41.7 µM -1.5231694084708 0.0650265503499801 no 3164 0.0638581637435895 4335 719745
SGTC_953 1188-0045 9.7 µM -1.52394926257332 0.06492926052057 no 3165 0.0637606930426176 4485 6144426
SGTC_2884 9058502 51.95 µM -1.52595549004961 0.0646794951032716 no 3166 0.0635104748834217 4491 6471554
SGTC_1901 st060216 58.6 µM -1.52813857974669 0.0644085596420309 no 3167 0.0632390672555925 4475 688792
SGTC_2854 9024559 71.43 µM -1.53333168219908 0.0637676063930101 no 3168 0.0625970760994889 4510 3163529
SGTC_2691 st077356 60.2 µM -1.53738781503837 0.0632704423150186 no 3169 0.0620991842347065 4494 2839272
SGTC_3230 9131665 49.47 µM -1.54332689451316 0.0625479345961389 no 3170 0.061375740681613 4544 15943720
SGTC_2297 7971671 152.32 µM -1.54929716509445 0.0618281313421494 no 3171 0.0606551504697644 4513 909016
SGTC_104 0074-0074 590.992 µM -1.5495980047967 0.0617920325569584 no 3172 0.0606190160764545 4376 3943124
SGTC_3242 9133940 49.47 µM -1.5552428798649 0.0611177309694104 no 3173 0.0599441177386329 4521 17248444
SGTC_1685 st024049 53.0905 µM -1.57079902839474 0.059289235703581 no 3174 0.0581146689199012 4547 1941139
SGTC_641 4092-0595 30 µM -1.57377877349226 0.0589439371994189 no 3175 0.0577693014931185 4570 786260
SGTC_771 0250-0039 27.3 µM -1.57553006592503 0.0587417314939806 no 3176 0.0575670720899123 4477 3005115
SGTC_1507 4075-3230 155 µM -1.58249794183561 0.0579426023828791 no 3177 0.056767970898491 4499 659771
SGTC_809 3998-0021 90 µM -1.58758269553598 0.0573648559660703 no 3178 0.0561903668706895 4494 715485
SGTC_2200 6600604 21.907 µM -1.58983147539066 0.0571107921361323 no 3179 0.0559363984966749 4577 2904777
SGTC_3348 9149464 3.537 µM -1.59042777256476 0.0570435721518525 no 3180 0.0558692071455351 4491 1951442
SGTC_1676 st018489 23.4 µM -1.59066909465328 0.0570163858652143 no 3181 0.0558420328415927 4505 3696235
SGTC_470 aa-861 153 µM -1.59682099598641 0.0563267783217719 no 3182 0.0551528071830576 4493 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2534 helenine 20.12 µM -1.6029972197411 0.0556410751863969 no 3183 0.0544676339578253 4553 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1092 toremifene 6.32 µM -1.60462468380566 0.0554614903502536 no 3184 0.0542882129309381 4545 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1408 3909-7976 48.8 µM -1.60520682742888 0.055397364118326 no 3185 0.0542241477261004 4585 24152374
SGTC_2806 7952793 58.44 µM -1.60634994797956 0.0552716136430087 no 3186 0.0540985208058303 4565 2972490
SGTC_18 0111-0177 500 nM -1.60653538019211 0.0552512361974583 no 3187 0.0540781638668244 4615 721752
SGTC_249 wiskostatin 11.211 µM -1.61789471029687 0.0540142168440721 no 3188 0.0528426452300327 4521 2775510 A n-wasp and actin depolymerizer.
SGTC_2904 7225135 42.03 µM -1.61894362335252 0.053901105857504 no 3189 0.0527296968429222 4614 4446116
SGTC_8 0354-0001 70 µM -1.62308600865012 0.0534562377584604 no 3190 0.0522855100523527 4555 4993152
SGTC_2013 4024628 200 µM -1.6287479117198 0.0528528940458423 no 3191 0.0516831977848847 4557 5230760
SGTC_2074 5212007 75.395 µM -1.62946131495684 0.0527772570950423 no 3192 0.0516076989373517 4489 758611
SGTC_3160 9100216 49.47 µM -1.63178236216947 0.0525317674320388 no 3193 0.0513626711072018 4546 17191039
SGTC_3000 9075062 71.4286 µM -1.63552866141421 0.0521374464369476 no 3194 0.0509691357012901 4544 17057871
SGTC_1715 st032160 10.2275 µM -1.63602362748748 0.0520855245128734 no 3195 0.050917321259581 4464 5289825
SGTC_761 k216-0224 480 µM -1.63858125583743 0.0518178835643441 no 3196 0.0506502493451845 4569 1340404
SGTC_3036 9090181 49.47 µM -1.64320009421599 0.0513373192557436 no 3197 0.0501707702065714 4618 25236586
SGTC_1260 0700-1617 7.75 µM -1.64346564922321 0.0513097978781552 no 3198 0.0501433134573531 4532 2853078
SGTC_393 acivicin 6.25 µM -1.64931391675937 0.0507066700070246 no 3199 0.0495416700071209 4428 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3329 9141233 27.5565 µM -1.64932690934373 0.0507053364036514 no 3200 0.0495403398310535 4529 4909101 YNL103W MET4
SGTC_1316 1272-0050 65.9 µM -1.65174444860716 0.0504576776452439 no 3201 0.0492933287146155 4573 7340392
SGTC_1332 1480-0653 17.5 µM -1.65279248757125 0.0503506138227846 no 3202 0.0491865517683464 4571 5749438
SGTC_999 SEC7.066 22.7 µM -1.654693936937 0.0501568309665108 no 3203 0.048993298785883 4528 740511 YDR170C SEC7
SGTC_3083 9117465 49.47 µM -1.65752399841064 0.0498695117534963 no 3204 0.0487067905436344 4530 16420915
SGTC_2864 9034755 47.6 µM -1.65847668265362 0.0497730872960239 no 3205 0.0486106450610832 4524 4930451
SGTC_2592 piperlongumine 83.33 µM -1.66658545438287 0.0489583787194069 no 3206 0.0477984315852029 4563 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2813 7971799 71.43 µM -1.66939781917713 0.0486783146588463 no 3207 0.0475192827843187 4559 2234054
SGTC_1842 st055362 61.2 µM -1.68136695289537 0.0475006853534085 no 3208 0.0463458302018468 4546 676032
SGTC_581 0958-0271 211 µM -1.6836528144607 0.0472783991442247 no 3209 0.0461243926988892 4591 4591145
SGTC_983 1491-0821 12.2 µM -1.68675495921538 0.0469780686050469 no 3210 0.0458252397007323 4582 46495113
SGTC_1936 st074407 74.3 µM -1.69566784274875 0.0461236836908485 no 3211 0.0449744008725433 4601 809813
SGTC_1013 4112-3890 241 µM -1.6965498450591 0.0460398183822289 no 3212 0.0448908994558672 4565 705171
SGTC_888 0916-0002 6.97 µM -1.69707056849545 0.045990362861321 no 3213 0.0448416598588329 4584 2802138 YIL048W NEO1
SGTC_283 0987-0079 11.7 µM -1.70076088553584 0.0456410982131383 no 3214 0.0444939484448577 4582 411556
SGTC_130 0136-0219 337.655 µM -1.70343054719154 0.0453897637270767 no 3215 0.0442437625705107 4508 234244
SGTC_1073 triclabendazole 3.09 µM -1.70373243609417 0.0453614126807968 no 3216 0.0442155427213219 4631 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.71437514726489 0.0443710017908836 no 3217 0.0432299249333588 4586 5377381
SGTC_1654 st012436 41.8 µM -1.71470335578651 0.0443407379150929 no 3218 0.0431998140043445 4594 4323132
SGTC_1796 st049173 110.4 µM -1.71565097308407 0.0442534521367544 no 3219 0.0431129715234706 4577 94134
SGTC_1128 3448-9350 235 µM -1.71712147752887 0.0441182770713264 no 3220 0.0429784893588019 4559 619386
SGTC_211 3455-0679 143.504 µM -1.71883946680186 0.0439607740000957 no 3221 0.0428218034667019 4564 748649
SGTC_1568 digitonin 820 nM -1.72439325078782 0.043454710391354 no 3222 0.042318437576731 4572 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1421 4029-0249 71.4 µM -1.72765110892114 0.0431600478802808 no 3223 0.0420253969364346 4673 2894095
SGTC_1294 1000-1494 117 µM -1.73087217148569 0.0428703021185187 no 3224 0.0417372830070134 4613 712797 YDL207W GLE1
SGTC_3328 9140624 29.0385 µM -1.73421952306478 0.0425708639185977 no 3225 0.0414395701116817 4592 4904392
SGTC_1468 k284-1086 134 µM -1.73739934988913 0.0422879802557174 no 3226 0.0411583529659401 4604 15996457
SGTC_2082 5219693 150 µM -1.74184750226848 0.0418948175860569 no 3227 0.0407675660660616 4570 2834649
SGTC_1497 4476-2978 41.3 µM -1.74204262940219 0.0418776387071408 no 3228 0.0407504925844351 4652 1528379
SGTC_689 0833-0039 98 µM -1.74616889623203 0.041515698263792 no 3229 0.0403908039253823 4567 5374726
SGTC_255 tunicamycin 200.472 nM -1.74767998735567 0.0413837868306609 no 3230 0.040259728040863 4525 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3026 9090633 49.47 µM -1.7539296424295 0.0408418235344777 no 3231 0.0397212818157861 4624 25236842
SGTC_1366 1683-0113 21.9 µM -1.75853371600009 0.0404462583444675 no 3232 0.0393283699991124 4620 708623
SGTC_1412 3909-8563 178 µM -1.76291655457847 0.0400725963925746 no 3233 0.0389572822640041 4689 23767530
SGTC_2250 alverine citrate 130 µM -1.77127882305843 0.0393674479446015 no 3234 0.0382571736058003 4484 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2290 7904846 200 µM -1.77316211423409 0.039210040394197 no 3235 0.038100923926047 4635 2962154
SGTC_2310 7668677 200 µM -1.77751265295582 0.0388483755794639 no 3236 0.0377419654516892 4579 2197143
SGTC_2980 9014342 25.29 µM -1.77941951263803 0.0386907150499446 no 3237 0.0375855048842205 4627 2996599
SGTC_2183 6420625 130.508 µM -1.78045103738794 0.0386056453493774 no 3238 0.0375010877749425 4637 2897619
SGTC_1383 3049-0032 20.7 µM -1.78207671424195 0.0384718854396718 no 3239 0.0373683612587445 4652 712864
SGTC_1105 epirubicin 18.1 µM -1.7834454684734 0.0383595581264412 no 3240 0.0372569086610821 4645 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2153 5569715 200 µM -1.78618968260939 0.0381351585825873 no 3241 0.0370342755249486 4639 2054701
SGTC_1727 st034309 9.9045 µM -1.78905241116983 0.0379022100789005 no 3242 0.0368031876142334 4630 870305
SGTC_3227 9130768 49.47 µM -1.79410802766164 0.0374936565530585 no 3243 0.0363979639955328 4687 17720899
SGTC_1929 genistein trimethyl ether 50.5 µM -1.79424447042537 0.0374826804027068 no 3244 0.0363870784863107 4582 136420
SGTC_2021 4019055 173 µM -1.79773160256775 0.0372030471421 no 3245 0.0361097754166207 4407 44827708 YER133W GLC7
SGTC_1686 st019653 115.5 µM -1.79905614192181 0.0370972799829931 no 3246 0.0360049001831554 4619 97252
SGTC_414 piperonyl butoxide 100 µM -1.80010399062285 0.0370137813521293 no 3247 0.0359221098051509 4621 5794 A potent inhibitor of cytochrome P450.
SGTC_972 1319-0219 195 µM -1.80129748677822 0.036918863895143 no 3248 0.0358280018813536 4613 23903702
SGTC_1820 st053765 18.6 µM -1.80319051568825 0.0367687215698031 no 3249 0.0356791497351924 4663 3690829
SGTC_2652 actinonin 100 µM -1.81004370874787 0.0362293432940458 no 3250 0.0351445046339251 4675 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_759 3486-0358 89.3 µM -1.81098929929338 0.0361554320492785 no 3251 0.0350712540518561 4609 875103
SGTC_1318 1280-3875 124 µM -1.81457176822578 0.0358765307234228 no 3252 0.0347948721683785 4648 373245
SGTC_2294 7971431 200 µM -1.81835752446445 0.0355837211218311 no 3253 0.0345047529666239 4616 5741572
SGTC_2276 7947513 42.08 µM -1.82094739230144 0.0353845383334706 no 3254 0.0343074270613619 4552 2105100
SGTC_3276 9139060 49.47 µM -1.82257211455652 0.0352600507990976 no 3255 0.034184111133393 4685 4870619
SGTC_562 3772-2733 112 µM -1.83362425277345 0.0344227299981225 no 3256 0.0333548947871553 4616 2876874 YIL048W NEO1
SGTC_114 0364-0001 490.298 µM -1.83405919353648 0.0343901155016424 no 3257 0.0333226039471929 4629 4003655
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.84054164943892 0.0339070240912602 no 3258 0.0328443777091595 4637 689007
SGTC_1742 st038235 28.8875 µM -1.84428989700814 0.0336302499847953 no 3259 0.0325704515377523 4653 564103 YBR002C RER2
SGTC_1504 k297-0033 30 µM -1.85173653508668 0.0330858990722067 no 3260 0.0320318324773307 4569 4388117
SGTC_1664 st014217 9.02 µM -1.85631944146749 0.0327545110472684 no 3261 0.0317040197913288 4700 3982782
SGTC_119 0121-0043 24.815 µM -1.87167980769546 0.0316637101670712 no 3262 0.0306254573701501 4642 1092378
SGTC_3037 9091026 49.47 µM -1.87170555517974 0.0316619072515727 no 3263 0.0306236752893959 4529 25236398 YIL048W NEO1
SGTC_210 3551-0445 56.827 µM -1.87292613607682 0.0315765358262844 no 3264 0.030539292751858 4619 2865180 YOR207C RET1
SGTC_1197 1601-0112 267 µM -1.87295818249406 0.0315742969605641 no 3265 0.0305370798810259 4627 7350313
SGTC_2425 5628681 7.85 µM -1.87329077310278 0.0315510688573926 no 3266 0.0305141216584594 4667 5714958
SGTC_1555 citronellol 128 µM -1.87396719111447 0.031503871446692 no 3267 0.0304674736619649 4637 8842 A terpine precursor.
SGTC_217 ketoconazole 989 nM -1.87496678669245 0.0314342310197353 no 3268 0.0303986464561341 4466 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1157 4092-0394 27.6 µM -1.87501601291259 0.031430804788545 no 3269 0.0303952603131744 4679 3659885
SGTC_2937 9044753 11.33 µM -1.8782037377347 0.0312095900292823 no 3270 0.0301766495214899 4588 6465530 YGL099W LSG1
SGTC_1606 st000094 49.2 µM -1.87832993515767 0.0312008590243944 no 3271 0.0301680219260022 4670 1242210
SGTC_1922 5578187 25 µM -1.88570018614028 0.030694439781243 no 3272 0.029667683903426 4620 1350412
SGTC_112 phenothiazine 287.218 µM -1.89246550969864 0.0302355953894533 no 3273 0.0292144924231542 4622 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2895 9054447 58.44 µM -1.89295686141515 0.0302024930795028 no 3274 0.0291818032516933 4705 2697450
SGTC_2004 4023728 41.89 µM -1.89367278971035 0.0301543148478715 no 3275 0.0291342276041913 4602 360084 YDR527W RBA50
SGTC_2486 5283202 22.39 µM -1.89809778332015 0.029857947777636 no 3276 0.0288416010646463 4646 1377751
SGTC_805 3852-0218 479 µM -1.90680202802548 0.0292820241657837 no 3277 0.0282731143200301 4651 6615355
SGTC_585 0kpi-0023 191 µM -1.90777309402478 0.029218348697443 no 3278 0.0282102748684165 4616 64601
SGTC_3272 9137413 49.47 µM -1.91355631067433 0.0288415052011865 no 3279 0.0278384359747745 4618 17614870
SGTC_1942 st076330 65.2 µM -1.91757137062652 0.0285822609508596 no 3280 0.0275826916013418 4673 24208414
SGTC_3291 9121177 71.43 µM -1.92277585073236 0.0282491056205406 no 3281 0.0272541030894197 4641 17015612
SGTC_1305 1181-0477 144 µM -1.92562176071694 0.0280683010055035 no 3282 0.0270758097788663 4692 6252086
SGTC_2580 diallyl disulphide 81.36 µM -1.93261137401314 0.027628327423072 no 3283 0.02664204510857 4631 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2353 9059630 146.67 µM -1.9326176850442 0.0276279327766401 no 3284 0.0266416560941742 4683 4779114
SGTC_1675 st018485 24.5 µM -1.93640317942604 0.0273920604062404 no 3285 0.0264091701957169 4655 3323024
SGTC_2674 ligustilide 100 µM -1.94396316869323 0.0269260252245453 no 3286 0.0259499463719377 4705 5319022 A signalling regulator.
SGTC_515 4092-1064 102 µM -1.94604915822853 0.0267986058636901 no 3287 0.0258244174604646 4632 717353
SGTC_1892 st058411 7.36 µM -1.94926502834037 0.0266031562221295 no 3288 0.0256318913399813 4664 3934738
SGTC_1641 st009299 47.1 µM -1.97012151687541 0.0253642730214729 no 3289 0.02441222273627 4637 4046054
SGTC_310 1273-0058 1.06 µM -1.97286446302608 0.0252049955173189 no 3290 0.02425550318251 4336 2734232
SGTC_1579 chlormadinone acetate 49.4 µM -1.9755884209761 0.0250476509471875 no 3291 0.0241007055649231 4704 45114258 A steroidal progestin.
SGTC_1186 1319-0216 26 µM -1.97964314603233 0.0248149626243866 no 3292 0.023871820602938 4704 4565136
SGTC_1868 st057644 42.7 µM -1.98310404115893 0.0246177891379106 no 3293 0.0236779046544408 4692 688665
SGTC_2680 butyl paraben 22.24 µM -1.98388865942832 0.0245732712799273 no 3294 0.0236341267171909 4739 7184 An antifungal and steroid mimetic.
SGTC_2172 5754775 163.918 µM -1.99234616282161 0.0240976818713824 no 3295 0.0231665449912309 4668 2263357
SGTC_1644 st010134 20.9 µM -1.99769709210096 0.0238007962291194 no 3296 0.0228747548361376 4676 3818134
SGTC_2264 7948757 110.76 µM -1.99941351618116 0.0237062176607895 no 3297 0.0227818153527583 4647 2971411
SGTC_2990 9074105 71.4286 µM -2.01114644926961 0.0230681361961634 no 3298 0.0221549950810114 4615 6502001
SGTC_1660 st012960 28.1 µM -2.01944820094511 0.0226254446389211 no 3299 0.0217203279941686 4712 24207266
SGTC_1659 st012954 42.1 µM -2.02016841139866 0.0225873792468428 no 3300 0.0216829608357163 4687 24207262
SGTC_2996 9066192 71.4286 µM -2.02771848459275 0.02219157372058 no 3301 0.0212944939936786 4654 6472854
SGTC_2612 dictamnine 15.46 µM -2.03348929027752 0.0218930053578232 no 3302 0.0210015572452474 4606 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_643 k048-0106 28.4 µM -2.04077628315591 0.0215208454824284 no 3303 0.0206365344950372 4721 6763920
SGTC_3044 9093193 49.47 µM -2.05291420929953 0.0209128132617209 no 3304 0.0200404493384082 4673 25236277
SGTC_1917 st066507 28.5 µM -2.08050460990511 0.0195846162510195 no 3305 0.018739636623091 4611 3156428
SGTC_2274 7947094 46.08 µM -2.10848211638516 0.0183116313591363 no 3306 0.0174946540357905 4689 2971028
SGTC_1275 0867-0008 21.1 µM -2.13055960749084 0.0173575032975075 no 3307 0.0165627201122792 4698 3422836
SGTC_2246 7293507 91.5585 µM -2.13519448239434 0.0171626818515154 no 3308 0.0163725637130723 4715 887656
SGTC_3290 9121031 71.43 µM -2.14837397801035 0.0166188780982738 no 3309 0.0158420291419539 4711 17014854
SGTC_1087 pterostilbene 9.05 µM -2.15519252700392 0.0163433698758919 no 3310 0.0155733857319366 4727 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1181 1222-0449 220 µM -2.16575389546743 0.0159243542929535 no 3311 0.0151649990798322 4741 658318
SGTC_1697 st025554 27.742 µM -2.16808004044612 0.0158333138515444 no 3312 0.0150762985921225 4739 1269519
SGTC_493 zm226600 134 µM -2.17066984295838 0.015732479860252 no 3313 0.0149780691895855 4714 5240098 A potassium channel opener. YCR052W RSC6
SGTC_671 0560-0003 407 µM -2.20916321659358 0.0142974601324263 no 3314 0.0135816451785819 4722 3238678
SGTC_2919 7978188 46.38 µM -2.22098577261045 0.0138799872445128 no 3315 0.0131759625211127 4706 2980291
SGTC_686 1319-0111 510 µM -2.23521726918179 0.0133914301995122 no 3316 0.0127015441442546 4727 4562600
SGTC_2123 5259487 200 µM -2.23673292748035 0.0133402844105941 no 3317 0.0126519002864224 4728 2173474
SGTC_3061 glucosamine 200 µM -2.24573971002847 0.0130398179760523 no 3318 0.0123603425257545 4684 91431 and experimental redox chemotherapeutic
SGTC_2226 7298446 200 µM -2.25912685951473 0.0126040376312512 no 3319 0.0119377474025264 4740 3283010
SGTC_781 4335-2806 94.4 µM -2.26800399191845 0.0123220688602904 no 3320 0.0116644816853108 4745 845254
SGTC_150 3970-0969 77.2 µM -2.27530524667936 0.0120942673168651 no 3321 0.0114438124625937 4729 6615640
SGTC_1780 st038448 24.544 µM -2.3023958737379 0.0112806421200614 no 3322 0.0106564287311843 4728 728868 YDL195W SEC31
SGTC_1089 terbinafine 2.25 µM -2.30996242227889 0.0110620689165702 no 3323 0.0104451173173099 4751 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1750 st081859 2.357 µM -2.31398727866347 0.0109473116425602 no 3324 0.0103342099800198 4670 5291695
SGTC_348 k064-0012 10.7 µM -2.32430451362141 0.0106578643294116 no 3325 0.0100545895392555 4730 5066323
SGTC_897 1000-0139 31.4 µM -2.32633944046757 0.0106015686531483 no 3326 0.0100002247749991 4726 6151020
SGTC_2638 epoxomicin 18 µM -2.32693286419028 0.0105852006124749 no 3327 0.00998441936441318 4722 9915668 A protesome inhibitor.
SGTC_2969 9091408 28.7 µM -2.32717961459607 0.0105784011308778 no 3328 0.00997785376748045 4692 4286311
SGTC_1414 3917-0015 5.4 µM -2.33537359292168 0.0103547577332377 no 3329 0.00976195634806106 4766 6618702
SGTC_2917 7979103 53.79 µM -2.35234956306547 0.00990450301173699 no 3330 0.00932761706899764 4741 2980565
SGTC_961 1252-1571 372 µM -2.35932454881257 0.00972451844505926 no 3331 0.00915411801685931 4744 6813498
SGTC_1570 verbenone 133 µM -2.36582688934547 0.00955931049100155 no 3332 0.00899492697577172 4741 29025 A natural terpanoid with antifungal properties.
SGTC_2922 7999257 32.47 µM -2.37677598123813 0.00928666247417775 no 3333 0.00873234558070943 4721 2988377
SGTC_2019 4016004 108 µM -2.38347106002644 0.00912331902154346 no 3334 0.00857511644272239 4729 45595336
SGTC_2176 5809774 33.9695 µM -2.39796999630227 0.00877817927912928 no 3335 0.00824310779577963 4726 2870539
SGTC_2036 5160441 105 µM -2.41987505760989 0.00827844908007415 no 3336 0.00776292031361472 4733 134534 YIL048W NEO1
SGTC_995 3931-2021 34.6 µM -2.42353473921875 0.00819744105664234 no 3337 0.00768514155996741 4737 730143
SGTC_2634 4'-methoxyflavone 100 µM -2.5253630717479 0.0062058008427037 no 3338 0.00577894061805956 4728 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_896 0964-0007 44.5 µM -2.52716484734138 0.00617480466267894 no 3339 0.00574937579345718 4743 6756758
SGTC_2835 9006588 71.43 µM -2.5366110645326 0.00601453381221648 no 3340 0.00559656157656599 4701 2345538
SGTC_1374 2889-5571 141 µM -2.54612751360827 0.00585681094764228 no 3341 0.0054462695576325 4750 2853281
SGTC_109 0132-0036 33.701 µM -2.54703131778018 0.00584202404766722 no 3342 0.00543218412655634 4744 67274 A color developer.
SGTC_2242 6630449 61.2675 µM -2.57763305946802 0.00536050752831699 no 3343 0.00497397866360457 4747 691249 YDR170C SEC7
SGTC_1764 st044502 93.5 µM -2.58057535168029 0.00531612426602528 no 3344 0.0049317913953902 4764 8407
SGTC_149 3970-0822 46.1 µM -2.59417492345973 0.00511519841940642 no 3345 0.00474091160083198 4752 3114250 YBL034C STU1
SGTC_1067 clotrimazole 1.36 µM -2.6092389323182 0.00490055236785513 no 3346 0.00453719288459191 4786 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_660 4031-1742 102 µM -2.66838363813683 0.00413336716904346 no 3347 0.00381085871969353 4707 6738706
SGTC_1587 estradiol valerate 56.1 µM -2.8076578068236 0.00273434143245616 no 3348 0.00249516114353272 4797 13791 A steroid.
SGTC_2193 5925765 200 µM -2.94683713232171 0.00177831582689142 no 3349 0.00160521123163066 4792 877370
SGTC_157 1348-1695 65.819 µM -2.99269647418238 0.00153741842944492 no 3350 0.00138262306458435 4754 5380510
SGTC_2198 6589944 200 µM -3.06588257571331 0.00121395936477334 no 3351 0.001085142648086 4801 5290268
SGTC_436 n,n-dimethylsphingosine 3.3 µM -3.27619632810211 0.000599395955387938 yes 3352 0.000526076964948473 4799 5282309
SGTC_2526 patulin 37.61 µM -3.28731842368006 0.000576794941819658 yes 3353 0.000505731966881843 4796 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2838 9002687 71.43 µM -3.58210080405401 0.000199889893449058 yes 3354 0.000170421107400641 4784 6457060
SGTC_2936 9038235 15.59 µM -3.64253679417526 0.000159287139884698 yes 3355 0.000134982187409232 4788 4749415
SGTC_1787 fluconazole 80 µM -5.41274093863737 4.59916072000966e-08 yes 3356 3.10336279311923e-08 4753 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C