SGTCid condition conc unit COX20|YDR231C.score COX20|YDR231C.strain.pval COX20|YDR231C.strain.significant COX20|YDR231C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_134 0269-0018 6.916 µM 24.604522487653 2.66543481366277e-133 yes 1 5.64982830786913e-134 1 4378915
SGTC_236 1509-0011 5.31 µM 22.7039979676024 7.72197147544558e-114 yes 2 2.04526738038026e-114 41 3107280
SGTC_386 1509-0011 3.07 µM 16.9179982960274 3.53236779433783e-64 yes 3 1.65753635211695e-64 16 3107280
SGTC_1635 st007035 42.4 µM 12.6800761919147 5.91639945386153e-37 yes 4 3.81288524781331e-37 52 3716403
SGTC_150 3970-0969 77.2 µM 8.02539294333261 6.11812186441312e-16 yes 5 5.06007394251021e-16 7 6615640
SGTC_149 3970-0822 46.1 µM 7.41621035156253 7.10626480699588e-14 yes 6 6.02595173074624e-14 17 3114250 YBL034C STU1
SGTC_59 0330-0160 1.33 µM 6.21327035325418 2.92783594968845e-10 yes 7 2.59465258656845e-10 33 4293482
SGTC_275 trichlorophene 5.69 µM 5.47320279603197 2.43529081925794e-08 yes 8 2.20986917420024e-08 140 62616
SGTC_87 0100-0052 35.5 µM 5.27307143382221 7.34835733666261e-08 yes 9 6.70796567671518e-08 46 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_119 0121-0043 24.815 µM 5.25134500999931 8.2651242341855e-08 yes 10 7.54962777611129e-08 46 1092378
SGTC_168 3970-0862 530.542 µM 4.87884291162561 5.77998922772474e-07 yes 11 5.33550046273007e-07 74 3135186
SGTC_118 0083-0097 135.343 µM 4.60697462382456 2.19701963679713e-06 yes 12 2.04284919950222e-06 80 5207356
SGTC_533 1222-0222 6.71 µM 4.29878421988008 9.16312634064315e-06 yes 13 8.58687846255141e-06 23 3982874
SGTC_157 1348-1695 65.819 µM 4.06105505479796 2.59165243537533e-05 yes 14 2.44257243985963e-05 67 5380510
SGTC_3094 9117742 49.47 µM 3.96733888912048 3.84739720574955e-05 yes 15 3.63398058028591e-05 19 17149698
SGTC_1133 3473-0247 50 µM 3.92651203824783 4.55814540771159e-05 yes 16 4.3093290323454e-05 50 711311
SGTC_310 1273-0058 1.06 µM 3.91084374440711 4.86250413445529e-05 yes 17 4.5987130928582e-05 247 2734232
SGTC_495 decylubiquinone 155 µM 3.71832629585704 0.000105572117945647 yes 18 0.000100273561069296 30 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1511 0906-3109 28.5 µM 3.71476929083184 0.000107059935014227 yes 19 0.000101694586373078 59 2882180
SGTC_1948 st076329 66.6 µM 3.68472110321651 0.000120437746574678 yes 20 0.000114476601277571 39 24208413
SGTC_1942 st076330 65.2 µM 3.6485213992842 0.000138636030991628 yes 21 0.000131876968406513 35 24208414
SGTC_3209 9113616 49.47 µM 3.58753494179915 0.000175236165343731 yes 22 0.000166909504515682 40 16649353
SGTC_2750 bromebric acid 70.15 µM 3.56811700520069 0.000188669217668988 yes 23 0.000179777972695264 44 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_335 4077-0256 27.6 µM 3.55766135685616 0.000196295084955148 yes 24 0.000187085629660982 22 3121989
SGTC_1480 1070-0044 41.2 µM 3.55169292233112 0.000200776344387878 yes 25 0.000191380639740139 30 3124987
SGTC_1620 st003704 16.5 µM 3.49578173663267 0.000247651415388597 yes 26 0.000236337582184531 28 2834414
SGTC_108 0509-0257 621.132 µM 3.39698070572576 0.000356255299498906 yes 27 0.00034066885400912 71 536624
SGTC_214 4373-3496 70 µM 3.38942518309431 0.000366162976629475 yes 28 0.00035019659276213 100 3779166
SGTC_2788 5282734 71.43 µM 3.34684364705076 0.000426953777337783 yes 29 0.000408686491730127 76 743706
SGTC_8 0354-0001 70 µM 3.33500169457103 0.000445452236388823 yes 30 0.000426494397353263 115 4993152
SGTC_1148 3909-7663 27.7 µM 3.30259958544173 0.000499933463114399 yes 31 0.000478965334859242 34 4084526
SGTC_2380 9035439 200 µM 3.217553232606 0.000673621793281072 yes 32 0.000646445164142746 64 6462575
SGTC_2928 9011484 9.79 µM 3.172899693827 0.000785670975493875 yes 33 0.000754623287937891 64 2994751
SGTC_2279 7948423 32.93 µM 3.07891055644792 0.00107961017324948 no 34 0.00103879523357328 40 1247112
SGTC_419 nsc-638432 893 µM 3.04773500122869 0.0011974662606753 no 35 0.00115286580482828 40 368090
SGTC_915 methyl methanesulfonate (MMS) 110 mM 3.02795261315052 0.00127824133962237 no 36 0.00123108346576822 82 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1534 6-azauridine 81.6 µM 2.92963833158029 0.00175862361617299 no 37 0.00169678363876508 81 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2265 7929201 200 µM 2.92088289553657 0.00180852488050443 no 38 0.00174520498839933 70 1265108
SGTC_1874 staurosporine 7.6 µM 2.86520885091819 0.00215712911277398 no 39 0.00208367146298882 89 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_70 0141-0289 43.283 µM 2.82890291337094 0.00241617979237943 no 40 0.00233539329715559 310 352408
SGTC_269 exalamide 29 µM 2.81142331938597 0.00255067214716775 no 41 0.00246614229055932 53 3316 A derivative of salicylamide.
SGTC_141 0443-0274 32.331 µM 2.80707482505701 0.00258516488730566 no 42 0.00249968138158557 131 1627241
SGTC_2072 5231554 129 µM 2.79856045273938 0.00265392500607745 no 43 0.00256654798843454 48 789545
SGTC_2434 5670830 169.91 µM 2.79586203574666 0.00267605900971662 no 44 0.00258807457478989 94 1549830
SGTC_3087 9117406 49.47 µM 2.79102199412147 0.00271617792376574 no 45 0.00262709509089951 72 42546093
SGTC_2786 7743617 45.45 µM 2.78179767870306 0.00279414457023344 no 46 0.00270293645285264 80 583674
SGTC_2440 5628896 157.78 µM 2.76767325475156 0.00291744612569949 no 47 0.00282290138524016 65 5522048
SGTC_15 0266-0086 27.098 µM 2.7384396590489 0.00318835023985655 no 48 0.00308657437540431 160 1712902 YIL048W NEO1
SGTC_3208 9114115 49.47 µM 2.73440749362267 0.00322744112397979 no 49 0.00312463261870119 117 650895
SGTC_1762 st045503 25.4615 µM 2.73440048265809 0.00322750946747351 no 50 0.00312469915911251 98 4645554
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.72834611404598 0.00328701631259743 no 51 0.00318263908199736 50 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1299 1079-1439 3.74 µM 2.70881505495389 0.0034857663854494 no 52 0.00337619841422382 78 323161
SGTC_538 2922-0838 53.3 µM 2.69897263327857 0.0035899585786266 no 53 0.00347769478532972 115 777039
SGTC_1305 1181-0477 144 µM 2.69331375256837 0.00365112140338202 no 54 0.00353728296165351 83 6252086
SGTC_801 0866-0028 10.1 µM 2.69323781701482 0.00365194845596141 no 55 0.00353808876080655 117 6849771
SGTC_2250 alverine citrate 130 µM 2.68827790151491 0.00370633483804101 no 56 0.00359107980478985 307 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_709 3807-1509 243 µM 2.67298850705412 0.00387858668178431 no 57 0.00375894130282984 64 1886677 YPL242C IQG1
SGTC_595 3909-8003 73.7 µM 2.64751660418604 0.00418153369286713 no 58 0.0040542688842381 71 699517
SGTC_2382 9035899 200 µM 2.63688856418982 0.00431407506776798 no 59 0.00418351564343592 73 6462679
SGTC_163 TUB2.036 7.546 µM 2.63229825046171 0.00437247259314406 no 60 0.00424046880043372 246 15992207 YJR013W GPI14
SGTC_1197 1601-0112 267 µM 2.62670385912728 0.00444459829050587 no 61 0.00431081657210171 111 7350313
SGTC_50 0929-0078 56.389 µM 2.62550257699094 0.00446022372763447 no 62 0.004326057698798 140 1377751
SGTC_1030 k029-0042 36.7 µM 2.62352506854597 0.00448605265753605 no 63 0.00435125202940768 129 6080581
SGTC_2537 larixol 68.93 µM 2.61136728827497 0.00464780523116893 no 64 0.00450904910068949 117 6708759
SGTC_1475 4092-1048 11.7 µM 2.60935516137014 0.00467507170631224 no 65 0.00453565191971971 138 2881759
SGTC_969 1313-0238 134 µM 2.59025911413782 0.00494103321719954 no 66 0.00479518574217546 122 5212874
SGTC_831 k061-1017 217 µM 2.56401910246775 0.00532846142300978 no 67 0.00517339249272678 205 1240153
SGTC_2853 9015042 58.44 µM 2.56166010183495 0.00536458117527784 no 68 0.00520866072744095 105 6457456
SGTC_560 2332-1943 155 µM 2.54571232263813 0.00561452717255754 no 69 0.0054527510188069 74 21177716
SGTC_116 0155-0182 31.788 µM 2.54511438996234 0.00562409635435029 no 70 0.00546209726827594 235 771486
SGTC_772 k072-0172 35.3 µM 2.4945069149581 0.00648839015888748 no 71 0.00630661344186543 112 5861980
SGTC_2126 5251174 33.877 µM 2.48843880683365 0.00659953716940173 no 72 0.00641526576704103 170 790722
SGTC_1515 3460-0031 42.1 µM 2.45785947860099 0.00718564972842061 no 73 0.00698839255839355 88 2876596
SGTC_2480 5767542 37.17 µM 2.45506968285534 0.00724134080856797 no 74 0.00704286405919623 92 2867358
SGTC_248 streptozotocin 5.23457 mM 2.44897788643197 0.00736427252404786 no 75 0.00716311216941225 123 5300 DNA alkylating agent.
SGTC_520 3584-0023 682 µM 2.43792206589301 0.00759208233524594 no 76 0.00738597917402628 129 1340790
SGTC_1078 idebenone 36.1 µM 2.42314210659875 0.0079063114367828 no 77 0.00769345315313676 186 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_637 1181-0519 7.26 µM 2.40622034470135 0.00828007182151024 no 78 0.00805926976544926 239 6252091 YGR060W ERG25
SGTC_1300 1094-0077 113 µM 2.40300066652264 0.00835291802544941 no 79 0.00813057889615013 109 5532636
SGTC_620 0109-0052 432 µM 2.39909589029441 0.00844201935509285 no 80 0.00821780501665471 114 493037
SGTC_3326 9140064 16.379 µM 2.39543979676689 0.00852620122300731 no 81 0.0083002200668283 122 1868434
SGTC_1513 0337-0559 19 µM 2.38672034244816 0.00872994666227159 no 82 0.00849970852832504 145 775073
SGTC_2268 7933382 153.85 µM 2.37129404479029 0.00910088138893246 no 83 0.00886296133428812 174 935025 YOR257W CDC31
SGTC_100 0086-0128 49.5915 µM 2.3604218896302 0.00937053183026092 no 84 0.00912708102535128 193 93297
SGTC_2646 retinol 96.75 µM 2.35048097217938 0.00962317620387554 no 85 0.00937458312529061 109 445354 A vitamin A analog and teratogen.
SGTC_2000 st075254 36.4 µM 2.3443595845288 0.00978169325971978 no 86 0.00952989289197856 93 17234175
SGTC_1188 1403-0014 4.57 µM 2.32631191191421 0.0102623974502983 no 87 0.0100009585078066 217 9614867
SGTC_382 3229-0966 23.2 µM 2.32360148239519 0.0103363416358409 no 88 0.0100734314578142 141 5722370
SGTC_2800 7887935 81.82 µM 2.30300749089667 0.0109135036334269 no 89 0.0106392108139002 162 2961002
SGTC_1491 4138-0063 26.5 µM 2.28688316036436 0.0113847809207134 no 90 0.011101321890457 97 23883227
SGTC_721 1187-1332 279 µM 2.28425699024827 0.0114631892343565 no 91 0.0111782159965833 95 25730
SGTC_2358 9037157 4 µM 2.28269462837931 0.0115100581287068 no 92 0.0112241812147371 168 2388925
SGTC_802 4112-3352 742 µM 2.27533062264131 0.0117332167931791 no 93 0.0114430518811184 164 704594
SGTC_1055 3448-0672 86 µM 2.27346667073597 0.0117902939843779 no 94 0.0114990362016991 170 748378
SGTC_272 doxorubicin 8.13 µM 2.27291579248063 0.0118072088184314 no 95 0.0115156274635843 192 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2008 4012253 172 µM 2.2728794706483 0.0118083248275943 no 96 0.0115167221288764 181 603940
SGTC_1772 st048439 82.2 µM 2.26775835152087 0.0119665931798763 no 97 0.0116719695797422 187 2927068 YDL195W SEC31
SGTC_1127 asiatic acid 681.4 nM 2.2673770267848 0.0119784512875385 no 98 0.0116836018274645 170 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1144 3486-0183 12.5 µM 2.26152941099552 0.0121615758146321 no 99 0.0118632467872434 178 6744069
SGTC_1479 0549-0158 134 µM 2.24538485411911 0.0126798107800262 no 100 0.0123717184398838 185 5440202
SGTC_81 0411-0046 9.971 µM 2.24440968249915 0.0127117165173852 no 101 0.0124030270527207 144 12925265
SGTC_638 3970-0837 4.09 µM 2.23867190149456 0.0129008560405203 no 102 0.0125886360426555 184 4118451 YLR208W SEC13
SGTC_1092 toremifene 6.32 µM 2.23133618940264 0.0131462106153501 no 103 0.0128294341011144 186 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1438 4092-1045 4 µM 2.22970530344326 0.0132013028479999 no 104 0.0128835067875593 131 1351342
SGTC_1944 st076371 56.9 µM 2.17796451500618 0.0150557263922998 no 105 0.0147043393485368 187 24208455
SGTC_976 1348-1067 47.6 µM 2.17625546137448 0.0151206200365463 no 106 0.0147680819445385 200 5310671 YGL099W LSG1
SGTC_1845 st056753 3.01 µM 2.17417496677742 0.0151999417243754 no 107 0.0148459988120743 206 5375839
SGTC_1353 1498-1206 8.11 µM 2.16783292303722 0.0154439501862665 no 108 0.0150857004506577 240 6756808
SGTC_2062 5245942 200 µM 2.16183473039063 0.0156778157126695 no 109 0.015315458712752 188 1376160
SGTC_499 genistein 192 µM 2.16032272357512 0.0157372450842704 no 110 0.0153738475219787 88 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_61 0978-8327 98.565 µM 2.15416744203897 0.0159811768911626 no 111 0.0156135215634468 190 6150059 YHR072W ERG7
SGTC_1339 1486-1321 22.7 µM 2.14993844658232 0.016150642842032 no 112 0.0157800419924122 194 3469382
SGTC_1104 tacrolimus 29.8 µM 2.14063410469427 0.0165289175840791 no 113 0.0161517781311372 194 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_375 3970-0961 9.27 µM 2.13887113317479 0.0166014406377842 no 114 0.0162230532514493 187 2898222
SGTC_1902 st060212 70.5 µM 2.13745732947899 0.016659796628096 no 115 0.0162804063936532 173 688944
SGTC_2404 5161160 200 µM 2.13426471694683 0.0167922205093917 no 116 0.0164105588703076 199 2831543
SGTC_1992 st073643 23.3 µM 2.13378223754219 0.0168123110013936 no 117 0.016430305278986 143 3161292
SGTC_942 3253-1115 227 µM 2.12863667545768 0.0170278545720127 no 118 0.0166421658536497 191 46497897
SGTC_423 5-fluorouracil 457 µM 2.11671198166075 0.0175364679548956 no 119 0.017142149666351 199 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2540 epiandrosterone 100 µM 2.10446447157605 0.0180722942173183 no 120 0.0176689753188465 286 441302 A steroid.
SGTC_2767 sibutramine 71.45 µM 2.10414083713025 0.0180866403827556 no 121 0.0176830817566688 181 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1887 st057648 70.8 µM 2.09680019748499 0.0184146553276921 no 122 0.0180056330566388 181 688672
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.09009945968316 0.0187184865319008 no 123 0.0183044331069098 173 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3166 9102297 49.47 µM 2.07511373620829 0.019413454092602 no 124 0.0189879974784488 223 25237072
SGTC_2630 antimycin a 100 µM 2.07147804465061 0.0195853267636389 no 125 0.0191570720687789 229 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1767 st044992 70.3 µM 2.07139246668925 0.0195893878686664 no 126 0.019161067163336 223 9600693
SGTC_1881 5652484 16 µM 2.0671584722701 0.0197912070411831 no 127 0.0193596119236534 219 2255129
SGTC_540 1187-0821 17.3 µM 2.06599341819183 0.0198470495916208 no 128 0.0194145505329443 201 847520
SGTC_262 fenpropimorph 62.5 µM 2.05587531886888 0.0203376705355151 no 129 0.0198972678390681 192 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3254 9136651 49.47 µM 2.05450339678795 0.020404979183389 no 130 0.0199634974783278 210 16454030
SGTC_2347 9049783 174.81 µM 2.05421842205149 0.0204189841458443 no 131 0.0199772780897788 251 6467988 YPL169C MEX67
SGTC_1950 st077106 7.18 µM 2.05024164247903 0.0206152728398988 no 132 0.0201704281012551 215 13831864
SGTC_1165 k072-0275 30.3 µM 2.04344745968184 0.0209543228672802 no 133 0.0205040817073804 217 6153523 YGL055W OLE1
SGTC_3152 9099253 49.47 µM 2.02356367803888 0.0219738139455837 no 134 0.0215075327177751 371 25236131
SGTC_856 0433-0016 11.3 µM 2.01905920243231 0.0222104993150013 no 135 0.0217405332801172 212 3911780
SGTC_2653 dihydrofissinolide 100 µM 2.01407808644373 0.0224747306074194 no 136 0.0220006679159637 151 6857746
SGTC_580 1123-0028 41 µM 2.00631861962533 0.0228916225838545 no 137 0.0224111323514588 301 1677248 YPR107C YTH1
SGTC_3029 9088683 49.47 µM 2.00557712144152 0.0229317998159291 no 138 0.0224506924429175 209 25236615
SGTC_2305 7443522 69.23 µM 1.99939701348374 0.023268978225228 no 139 0.0227827074096289 211 5415886
SGTC_2173 5763948 167 µM 1.99661755264572 0.0234219768646118 no 140 0.022933372303241 206 2867177
SGTC_2059 5238311 157 µM 1.99190854755022 0.0236831212105435 no 141 0.0231905464818943 224 703021
SGTC_1183 1254-0324 198 µM 1.97857230953041 0.0244360194880977 no 142 0.0239320899302748 203 5799357
SGTC_2211 7117706 200 µM 1.9754464490538 0.0246153677147342 no 143 0.0241087530224712 188 822771
SGTC_204 PMA1.184 62.41 µM 1.97330591346281 0.0247388184086833 no 144 0.0242303598019649 239 2252213 YGL008C PMA1
SGTC_159 3970-0959 50 µM 1.9718044107837 0.0248257238730027 no 145 0.0243159693206254 436 6615653
SGTC_400 oxethazaine 37.5 µM 1.96826601665675 0.025031535669708 no 146 0.0245187189499718 226 4621 A local anesthetic.
SGTC_127 0180-0333 59.125 µM 1.96781219477523 0.0250580355603167 no 147 0.0245448252670906 311 771601
SGTC_1074 carmofur 3.8 µM 1.95961825490917 0.025540561907359 no 148 0.0250202130395908 294 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1152 3909-8331 15.9 µM 1.95449542007707 0.0258461710567081 no 149 0.0253213279854462 205 16001939
SGTC_793 0488-0545 106 µM 1.95358729092851 0.025900664681038 no 150 0.0253750224200093 219 292548
SGTC_2641 levomentholum 100 µM 1.94971176239463 0.0261343031115344 no 151 0.0256052417850783 144 16666
SGTC_3185 9108267 49.47 µM 1.93940446941078 0.0267642744395186 no 152 0.026226053367486 263 4910486
SGTC_2887 9044784 58.44 µM 1.93845657694581 0.0268228400865568 no 153 0.0262837718155077 270 6465546
SGTC_1218 1348-1416 30.7 µM 1.93693971651148 0.0269167820892967 no 154 0.0263763563997548 228 6787668
SGTC_578 3460-0051 92 µM 1.91732731902977 0.0281563441191791 no 155 0.0275981806795444 262 2876744
SGTC_820 1582-0060 59.9 µM 1.90833364988198 0.0287404660737214 no 156 0.0281740532345908 268 3848840
SGTC_2155 5570423 76 µM 1.90437699344429 0.0290006165512623 no 157 0.0284305516514572 227 797402
SGTC_173 1273-0061 2.693 µM 1.90349037516794 0.0290591793741034 no 158 0.0284882942023223 387 2847414 YPL266W DIM1
SGTC_114 0364-0001 490.298 µM 1.90029033076046 0.0292713663364907 no 159 0.0286975147802423 291 4003655
SGTC_3200 9114385 49.47 µM 1.89495309127703 0.0296281275243814 no 160 0.02904930826855 254 17018030 YLR208W SEC13
SGTC_1478 0453-0656 35.7 µM 1.89365592538343 0.0297153779595461 no 161 0.0291353475493011 244 5258496
SGTC_1761 st044296 37 µM 1.89011201510349 0.0299548371560542 no 162 0.0293714902611394 232 1826700
SGTC_816 0325-0417 81.3 µM 1.88873171539416 0.0300485349298543 no 163 0.0294638933228613 213 68101
SGTC_496 calpeptin 138 µM 1.88477813494235 0.0303182583802121 no 164 0.0297298990797461 232 73364 A calpain inhibitor.
SGTC_2165 5727197 32.143 µM 1.88243173349645 0.0304792825186241 no 165 0.0298887103330723 286 1361712
SGTC_1572 epiandrosterone 68.9 µM 1.87804690242007 0.03078209496494 no 166 0.0301873745531181 259 441302 A steroid.
SGTC_387 norethindrone acetate 66.7 µM 1.87536316377622 0.0309686571952289 no 167 0.0303713895852729 240 541197
SGTC_3090 9117696 49.47 µM 1.87250404650706 0.031168439458125 no 168 0.0305684513001287 224 7923821
SGTC_1621 st003705 32.4 µM 1.86965875214145 0.0313683130575169 no 169 0.0307656104594479 286 24207032
SGTC_2499 avocadenofuran 51.48 µM 1.86545801355428 0.0316653390361109 no 170 0.0310586160772374 286 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2083 5306046 65.942 µM 1.86210545498605 0.0319040561236355 no 171 0.0312941136328381 306 539837
SGTC_2549 cedrol 20.94 µM 1.85858589204642 0.0321562619815023 no 172 0.0315429291732733 200 6708665 A sedative which affects the nervous system.
SGTC_447 ml7 120 µM 1.84254637038604 0.0333265525486229 no 173 0.03269763513601 257 4216 Selective myosin light chain kinase inhibitor.
SGTC_2181 6316240 54.2555 µM 1.83624566591755 0.0337957648982719 no 174 0.0331606657995787 251 12779990
SGTC_2205 7238770 200 µM 1.83605285674859 0.0338102086320602 no 175 0.0331749198392666 206 279867
SGTC_2363 9053361 176 µM 1.83248722456112 0.0340782341361697 no 176 0.0334394316959777 299 6469797 YMR079W SEC14
SGTC_2183 6420625 130.508 µM 1.83017670731339 0.0342528447661086 no 177 0.0336117598102765 360 2897619
SGTC_2662 daunorubicin 22.37 µM 1.82782698752745 0.0344311715474899 no 178 0.0337877607769326 242 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1486 3970-0793 4.53 µM 1.81094432896683 0.0357349910494883 no 179 0.035074734858038 223 2844330
SGTC_2635 hydroquinidine 100 µM 1.80199480773182 0.0364423919901737 no 180 0.0357731112395116 271 442912 An experimental heart treatment.
SGTC_2793 7325131 81.82 µM 1.80198888406264 0.0364428639849736 no 181 0.0357735772394442 247 4176441
SGTC_2425 5628681 7.85 µM 1.79946507411161 0.0366444154021949 no 182 0.0359725719331292 326 5714958
SGTC_3121 9125696 49.47 µM 1.79639640300787 0.0368907068375979 no 183 0.0362157477612193 216 1235365
SGTC_399 oxolinic acid 75 µM 1.7764486102396 0.0385248975408949 no 184 0.0378295025165398 247 4628 A DNA gyrase inhibitor.
SGTC_2333 9017922 200 µM 1.77591895688833 0.0385690798815512 no 185 0.0378731379630686 293 3163164
SGTC_2213 7173844 200 µM 1.77502466429283 0.038643773215901 no 186 0.0379469073971204 281 892728
SGTC_1682 st012968 530 nM 1.76826833946085 0.0392118930291509 no 187 0.0385080270838653 248 24207270
SGTC_698 k064-0052 127 µM 1.76782380494222 0.0392495097484996 no 188 0.03854518198671 201 5088751
SGTC_1003 4049-0218 100 µM 1.76658468895309 0.0393545193682073 no 189 0.0386489035123484 324 295161
SGTC_46 0329-0187a 2.197 µM 1.76502921037754 0.0394866627901635 no 190 0.0387794282972664 413 46494817
SGTC_924 2046-0044 21.3 µM 1.75664801262074 0.0402048998487423 no 191 0.0394889119250085 295 3623589
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.75612245065045 0.0402502898405372 no 192 0.0395337512282605 278 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_98 0074-0023 107.663 µM 1.75386585290032 0.0404456534269309 no 193 0.0397267479512485 331 3563821
SGTC_2433 5607874 27.82 µM 1.74720156637834 0.0410271078932874 no 194 0.0403011900639801 328 2252428
SGTC_91 0417-1751 58.384 µM 1.74685009450414 0.0410579608060355 no 195 0.0403316722224049 397 6795624
SGTC_3234 9132280 49.47 µM 1.74048727253255 0.0416197628985236 no 196 0.0408867464975618 321 17612295
SGTC_2844 9010103 25.97 µM 1.73147062003476 0.042426531789344 no 197 0.0416839302928732 349 2480525
SGTC_2939 9044578 71.43 µM 1.73105157927774 0.0424643310951906 no 198 0.0417212826930441 330 2653634
SGTC_522 1273-0010 11.6 µM 1.73093695929621 0.0424746750605786 no 199 0.0417315043943144 304 5705015
SGTC_3056 9094900 49.47 µM 1.73077580434146 0.0424892220559113 no 200 0.0417458794709192 328 25236784
SGTC_470 aa-861 153 µM 1.72942914076702 0.0426109390858155 no 201 0.0418661591536931 365 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2725 haloperidol 53.21 µM 1.72336702903761 0.0431623531953298 no 202 0.0424110866840883 334 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1477 0139-0234 16 µM 1.7198630580885 0.0434836963689405 no 203 0.0427286684938361 285 620880
SGTC_2251 lansoprazole 556 µM 1.71662207011896 0.0437826383780658 no 204 0.0430241236465618 243 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_395 anisomycin 6.25 µM 1.71458117540582 0.0439717355292368 no 205 0.0432110212544712 250 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2080 5212524 12.4 µM 1.71188733529091 0.0442223385460388 no 206 0.043458716527212 275 260183
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.71039331506612 0.0443618200506701 no 207 0.0435965831812357 276 688803
SGTC_2952 9073731 13.78 µM 1.710044110658 0.044394472786173 no 208 0.0436288582446341 378 16457353
SGTC_1847 st056231 15 µM 1.70751503801874 0.0446315348930703 no 209 0.043863182562698 396 5393180
SGTC_952 1185-0122 232 µM 1.70749960556396 0.0446329845747373 no 210 0.0438646155246325 330 678600
SGTC_2119 5528445 120.635 µM 1.70689806295809 0.0446895213631586 no 211 0.0439205004644764 311 791935
SGTC_594 1487-1584 10.8 µM 1.70594708193951 0.0447790182397927 no 212 0.0440089663181952 323 5013332
SGTC_977 1348-1378 135 µM 1.69924368292454 0.0454139766811239 no 213 0.0446366394224127 312 X977
SGTC_1068 loratadine 26.9 µM 1.69647914140038 0.0456779393229268 no 214 0.0448975885474387 312 3957 A H1 histamine antagonist.
SGTC_2047 4141938 200 µM 1.69573692420237 0.0457490169685099 no 215 0.0449678562450958 268 3807862
SGTC_763 3453-1109 128 µM 1.694085124726 0.0459075188704359 no 216 0.0451245542713589 333 1560353
SGTC_2326 6164455 177.58 µM 1.69111944210391 0.0461932042792307 no 217 0.0454069963270421 318 2888790
SGTC_1773 st048542 73.5835 µM 1.68275779732258 0.0470063781515426 no 218 0.0462109939570532 370 3237138
SGTC_1777 st045864 34.765 µM 1.6800750142556 0.0472696989207903 no 219 0.0464713607665245 324 4691462
SGTC_34 0469-0683 81.75 µM 1.67649573012 0.0476228525178862 no 220 0.046820565939815 310 3690923
SGTC_877 0771-0151 33.1 µM 1.67531435649297 0.0477398766780115 no 221 0.0469362850564019 354 6166523
SGTC_1164 k060-0068 93.7 µM 1.67130213628263 0.0481390379459928 no 222 0.0473310073509603 365 5963676
SGTC_1868 st057644 42.7 µM 1.66946052860392 0.048323144859497 no 223 0.0475130733092167 370 688665
SGTC_957 1187-1561 14.1 µM 1.6694465143968 0.0483245480266463 no 224 0.0475144609368442 364 1538454
SGTC_429 1112-0049 25.5 µM 1.66741843987007 0.0485279520865765 no 225 0.0477156148636562 334 2836170
SGTC_890 0929-0006 47.2 µM 1.66557549642928 0.0487133817305617 no 226 0.0478989975065093 297 1378169
SGTC_1933 st074711 15.9 µM 1.66537763206216 0.0487333236784674 no 227 0.0479187195537273 364 17250958
SGTC_700 3453-2283 142 µM 1.66222748963713 0.0490516935153458 no 228 0.0482335850848206 389 565664
SGTC_617 3770-0098 35 µM 1.66053684918036 0.0492232423325539 no 229 0.048403250614174 333 5962639
SGTC_1052 3253-3998 198 µM 1.65905938695749 0.0493735520062372 no 230 0.0485519130063437 388 5450317
SGTC_460 trequinsin 123 µM 1.65905905614115 0.0493735857028357 no 231 0.0485519463339495 293 5537 A vasodilator.
SGTC_1401 3807-4679 7.6 µM 1.65814101722295 0.0494671669093929 no 232 0.0486445032969985 311 3291456
SGTC_2256 7954252 200 µM 1.6565382772865 0.0496308830902071 no 233 0.0488064300683742 261 2972920
SGTC_2156 5649887 115 µM 1.65447961475491 0.0498418047339071 no 234 0.049015050948372 379 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2419 paclitaxel 166.5 µM 1.64627933063359 0.0506890756377889 no 235 0.0498531314636343 438 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1745 st081495 74 µM 1.64346588133109 0.0509823961537211 no 236 0.0501432894640712 431 13842402 YBL026W LSM2
SGTC_2904 7225135 42.03 µM 1.63426009354247 0.0519516120735656 no 237 0.051102124599061 347 4446116
SGTC_2098 5376439 882.5 nM 1.63355882709936 0.0520260398017585 no 238 0.0511757595171363 373 2844116
SGTC_767 0929-0023 86 µM 1.62519656136637 0.0529200974322905 no 239 0.0520603414518989 477 1204563
SGTC_930 2810-3379 265 µM 1.62093777600856 0.0533800891811431 no 240 0.0525154920987788 409 1015764
SGTC_508 roscovitine 141 µM 1.61959722550775 0.0535255360279823 no 241 0.0526594129971199 306 160355 A CDKinase inhibitor.
SGTC_300 r073-0011 5.04 µM 1.61928425567583 0.0535595377505222 no 242 0.0526930583222285 405 2735780
SGTC_2366 9070441 60.58 µM 1.61181808309568 0.0543757635823186 no 243 0.0535007659857642 379 6837235
SGTC_1037 k284-1091 78.7 µM 1.60995766911493 0.0545806737962926 no 244 0.0537035489234256 303 3334711
SGTC_2247 cerulenin 830 nM 1.60914151420281 0.0546707594297886 no 245 0.0537927007423596 373 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2980 9014342 25.29 µM 1.60383857520884 0.0552589543829824 no 246 0.0543748196061477 359 2996599
SGTC_2152 5568786 200 µM 1.60162867939165 0.0555055437365438 no 247 0.0546188724799744 369 5399883
SGTC_195 4234-0266 16.654 µM 1.60100338405338 0.0555754742357414 no 248 0.0546880848119794 414 2303354
SGTC_1665 st014639 11.4 µM 1.60057406950793 0.0556235272890359 no 249 0.0547356446688013 404 981133 YIL048W NEO1
SGTC_1067 clotrimazole 1.36 µM 1.60055980604408 0.0556251243571232 no 250 0.054737225349376 399 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3149 9097855 49.47 µM 1.59349569924027 0.0564205441602896 no 251 0.0555245161858139 346 25236625 YMR079W SEC14
SGTC_1072 oxiconazole 14.9 nM 1.58804199066898 0.0570407432689552 no 252 0.0561384221309383 416 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_353 1988-1175 58.3 µM 1.58714696538634 0.0571430368624527 no 253 0.0562396815136907 345 2788357
SGTC_7 0192-1582 4.227 µM 1.5847611782571 0.0574164170659606 no 254 0.0565103029822031 470 252616
SGTC_573 3702-0553 84.7 µM 1.58277815810032 0.057644427579185 no 255 0.0567360183624773 367 1222756
SGTC_3037 9091026 49.47 µM 1.58179732097193 0.0577574685463695 no 256 0.0568479234077231 531 25236398 YIL048W NEO1
SGTC_2359 9039622 200 µM 1.57981557016057 0.0579863960711798 no 257 0.0570745544167579 379 6463596
SGTC_1301 naphtanilide LB 4.81 µM 1.57928949095043 0.0580472872200081 no 258 0.0571348356104888 390 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1747 st037496 66.6 µM 1.57887986390186 0.0580947343749202 no 259 0.0571818077371523 417 723305
SGTC_3214 9129694 49.47 µM 1.57872230495362 0.0581129925618286 no 260 0.0571998831877857 360 17158655
SGTC_1743 st037606 46.3785 µM 1.57772041958693 0.0582291981783502 no 261 0.0573149265437367 388 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_348 k064-0012 10.7 µM 1.57481843496388 0.0585668208136512 no 262 0.0576491799707423 340 5066323
SGTC_1317 1273-0028 910 nM 1.5738719188831 0.0586772721513223 no 263 0.0577585315417906 374 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_825 1988-2224 89.6 µM 1.57373237267922 0.0586935699692817 no 264 0.0577746671840169 413 1180859
SGTC_914 3820-6779 408 µM 1.5720689200791 0.058888120926438 no 265 0.0579672842330825 376 2893481
SGTC_2914 7968218 45.32 µM 1.56648984646901 0.0595443240862069 no 266 0.058616991884214 326 2977111
SGTC_2154 5570129 200 µM 1.56648620410651 0.059544754360306 no 267 0.0586174179129888 418 673366
SGTC_2520 obtusaquinone 4.71 µM 1.56627353415488 0.0595698813929005 no 268 0.0586422970595085 382 5967872
SGTC_2231 micatex 6.853 µM 1.56616079152435 0.0595832053458905 no 269 0.0586554895924336 323 20737 An antifungal of unknown mechanism.
SGTC_1053 3366-3204 134 µM 1.56227042559384 0.0600444021271267 no 270 0.0591121480006806 422 3632071 YPR165W RHO1
SGTC_31 0508-1974 57.237 µM 1.55652949315487 0.060730081117538 no 271 0.0597911175214998 376 6810525
SGTC_1361 1608-0041 5.61 µM 1.5559655949588 0.0607977603189723 no 272 0.0598581369133577 397 X1361
SGTC_3315 9136395 68.55 µM 1.55596111959106 0.0607982976895308 no 273 0.0598586690467987 390 16876844
SGTC_1042 0350-0096 82 µM 1.55047316247944 0.0614600522319941 no 274 0.0605139950654177 374 3122515
SGTC_881 0833-0569 170 µM 1.54879515684666 0.0616635103975275 no 275 0.0607154850872412 413 5418700
SGTC_3240 9133527 49.47 µM 1.5485746256212 0.0616902888601088 no 276 0.0607420047996351 369 17617455
SGTC_2055 5235184 200 µM 1.54167499737622 0.0625326848800355 no 277 0.0615762953211198 412 2836034
SGTC_1145 3546-0597 10.2 µM 1.54022005352668 0.0627114629333482 no 278 0.0617533616740111 432 875334
SGTC_144 4161-2749 112.381 µM 1.53903176074241 0.0628577712125055 no 279 0.0618982713322226 338 797501 YMR168C CEP3
SGTC_2043 5101342 149 µM 1.53164797916607 0.0637728659943717 no 280 0.0628046629727904 414 678451
SGTC_866 0495-0101 262 µM 1.53070145868646 0.0638909167476235 no 281 0.0629215965566917 358 635694
SGTC_1963 st076565 50.3 µM 1.52239289524376 0.064934473073237 no 282 0.063955331988373 409 4914280
SGTC_1603 st002045 67.8 µM 1.52197409052197 0.0649874232169567 no 283 0.0640077864259394 404 5887985
SGTC_1177 0983-0204 23.6 µM 1.5186462181798 0.0654093633851346 no 284 0.0644257854223875 424 766818
SGTC_3047 9092122 49.47 µM 1.51493870661537 0.0658819368280438 no 285 0.0648939634937633 410 17173831
SGTC_3021 9087658 49.47 µM 1.51313035965182 0.066113393548517 no 286 0.0651232746371921 340 25237042
SGTC_882 0843-0131 351 µM 1.51118050652802 0.066363667406506 no 287 0.0653712337763899 434 5425421
SGTC_818 4072-2707 53.5 µM 1.50684546343664 0.066922720985899 no 288 0.0659251365663117 362 882871
SGTC_2274 7947094 46.08 µM 1.50336506721124 0.0673741889712988 no 289 0.0663724647870459 447 2971028
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.50172794665796 0.0675873644680867 no 290 0.0665836916682079 441 165521
SGTC_143 4032-1194 15.74 µM 1.50136500851389 0.067634694480809 no 291 0.0666305895720024 517 1806963
SGTC_1713 st033146 12.748 µM 1.49990128235513 0.0678258359058664 no 292 0.0668199878875265 420 674619
SGTC_2704 st078022 71.1 µM 1.49832316194109 0.0680323826629282 no 293 0.0670246545615528 404 54697681
SGTC_2863 9028737 58.44 µM 1.49817615540093 0.0680516477968634 no 294 0.0670437445212146 348 6460917
SGTC_2292 7671323 168.05 µM 1.4977403402345 0.0681087859092344 no 295 0.0671003632735568 440 937504
SGTC_3010 9080089 71.4286 µM 1.49356664261954 0.0686578611192516 no 296 0.0676444617870927 399 17027233
SGTC_2748 diazoxide 86.69 µM 1.49040411440831 0.0690761794278301 no 297 0.0680590056732919 353 3019 A potassium channel activatior.
SGTC_2581 avocatin a 64 µM 1.48965775072529 0.0691751893651384 no 298 0.0681571244151932 478 6710728 A skin care supplement.
SGTC_769 0302-0231 76 µM 1.48713498297209 0.0695106602773505 no 299 0.0684895818410008 532 571869 YER009W NTF2
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.48619129038212 0.0696364714708029 no 300 0.0686142653174662 429 688669
SGTC_1726 st035556 14.5795 µM 1.48149942426832 0.0702645857077181 no 301 0.0692367691103246 485 5919439
SGTC_2659 sanguinarine 24.21 µM 1.47791529887201 0.0707473318375185 no 302 0.0697152254328992 433 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3111 9122088 49.47 µM 1.47699399636049 0.0708718329456181 no 303 0.0698386233007446 310 16876704
SGTC_1806 st050005 60.3 µM 1.47608182269786 0.0709952661718951 no 304 0.0699609640037427 432 5194765
SGTC_3348 9149464 3.537 µM 1.47584877333813 0.0710268283369862 no 305 0.0699922470082929 427 1951442
SGTC_799 1310-0557 151 µM 1.4734101529087 0.0713577404065172 no 306 0.0703202371301655 452 5354492
SGTC_3298 9116858 71.43 µM 1.47299963251465 0.0714135627410924 no 307 0.0703755674344154 426 2506942
SGTC_1581 himbacine 57.9 µM 1.47032850311511 0.0717776002821382 no 308 0.0707364024766426 468 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2781 5567276 71.43 µM 1.46955278172181 0.0718835864986189 no 309 0.0708414583332337 443 2853274
SGTC_800 3448-7362 155 µM 1.45872741039612 0.0733752003711164 no 310 0.0723200743356463 727 15991913
SGTC_2911 7942208 15.64 µM 1.45862013122434 0.0733900998012951 no 311 0.072334844827566 388 1243384
SGTC_2899 9053889 58.44 µM 1.45385111775745 0.0740547830961394 no 312 0.0729937938488758 394 6470052
SGTC_1804 st050076 49.1 µM 1.44729382658998 0.0749762048426664 no 313 0.0739073237075898 456 3895976
SGTC_2082 5219693 150 µM 1.44711033415787 0.075002114157933 no 314 0.0739330120673674 462 2834649
SGTC_2972 9093619 59.92 µM 1.44497671667386 0.0753038846337378 no 315 0.0742322128621591 444 25236256
SGTC_2598 perillyl alcohol 100 µM 1.44451214930764 0.07536971375426 no 316 0.07429748235977 457 10819 An apoptosis inducer.
SGTC_3284 9108171 64.8615 µM 1.44204411321298 0.0757201697611326 no 317 0.0746449647088037 405 8687505
SGTC_2644 guaiazulene 100 µM 1.44047685648388 0.0759433605226283 no 318 0.074866266590109 412 3515 A coloring agent.
SGTC_1913 st060213 96.1 µM 1.43510091419839 0.0767127476970774 no 319 0.0756291715474603 493 688959
SGTC_1464 k208-0027 110 µM 1.43251708348992 0.0770846395709169 no 320 0.0759979462831965 475 X1464
SGTC_2713 st079149 53.4 µM 1.43194570760936 0.0771670626295643 no 321 0.0760796798991878 481 3103253
SGTC_2699 st077704 54.6 µM 1.43084778064331 0.0773256305485032 no 322 0.0762369228873723 465 645852
SGTC_2458 5808907 16.39 µM 1.42780744967694 0.0777660214891821 no 323 0.0766736440028821 462 2731747
SGTC_2623 humulene 100 µM 1.42641746038494 0.0779679940132769 no 324 0.0768739383245422 398 6187145 An anti-inflammatory.
SGTC_1667 st014849 34.6 µM 1.42458533308644 0.0782348191894018 no 325 0.0771385510977046 466 5348460
SGTC_2054 5233173 129 µM 1.42358685409 0.0783805257447182 no 326 0.0772830517506281 524 6889
SGTC_1172 0370-0043 85 µM 1.42328891845937 0.078424042881804 no 327 0.0773262090351179 432 376585
SGTC_2149 5554786 194.827 µM 1.4121899609021 0.0800582644031866 no 328 0.0789470178312283 520 745063 YPR165W RHO1
SGTC_2768 sulfasalazine 50.2 µM 1.40680321614346 0.0808606349933732 no 329 0.0797428743237196 466 5384001 An antioxidant and salicylic acid derivative.
SGTC_3250 9135583 49.47 µM 1.40660996320185 0.080889532956525 no 330 0.0797715385439389 444 7699353
SGTC_448 monastrol 171 µM 1.40537844054368 0.0810738711392709 no 331 0.0799543871089946 464 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.40277684890619 0.0814643275640659 no 332 0.0803416963434973 476 115019
SGTC_1307 1187-1599 12.2 µM 1.3989114269977 0.0820470808771133 no 333 0.0809197727394626 471 1538471
SGTC_1191 1487-1166 10.6 µM 1.39382306029529 0.0828189874013396 no 334 0.0816855213462998 561 3955771
SGTC_1023 4482-3888 16 µM 1.39356332201545 0.0828585358444409 no 335 0.0817247554210065 460 3303168
SGTC_2754 granisetron 64.02 µM 1.39338065989894 0.0828863569738459 no 336 0.081752355467622 512 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_658 3253-0951 102 µM 1.38333541199739 0.0844271837797895 no 337 0.0832810223328013 607 1184878
SGTC_833 3852-0053 558 µM 1.38312692507462 0.0844593894231662 no 338 0.0833129755718511 547 3123681
SGTC_222 nsc-310342 10.666 µM 1.37920184512086 0.0850674305196104 no 339 0.0839162646733538 348 432556
SGTC_190 3970-0790 3.722 µM 1.37805091450388 0.0852463437709111 no 340 0.0840937844987786 444 2832352
SGTC_2665 lovastatin 100 µM 1.37562420938485 0.0856245010355446 no 341 0.0844690037588887 479 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3277 9138724 49.47 µM 1.37324746372877 0.0859960891837385 no 342 0.0848377144129885 374 15943418
SGTC_3006 9075424 71.4286 µM 1.37299669489039 0.0860353654636902 no 343 0.0848766870934208 478 7465181
SGTC_2132 5317594 122.667 µM 1.3719490850378 0.0861995908916693 no 344 0.0850396442149123 439 794577
SGTC_1264 0783-0040 158 µM 1.37125675280484 0.0863082508972347 no 345 0.0851474660453466 465 2855798
SGTC_1318 1280-3875 124 µM 1.36782810115529 0.0868478803282247 no 346 0.0856829446975037 529 373245
SGTC_2478 5763493 32.33 µM 1.36727311263605 0.0869354655240577 no 347 0.0857698580413243 506 1365576 YLR208W SEC13
SGTC_1685 st024049 53.0905 µM 1.36703961414631 0.0869723346692401 no 348 0.085806444522923 457 1941139
SGTC_3283 9109332 35.8195 µM 1.36595833285213 0.0871432200410537 no 349 0.0859760209609854 398 17027281
SGTC_1449 4112-4002 201 µM 1.36360447953674 0.0875160891348834 no 350 0.086346040752783 484 2059539
SGTC_2650 prasterone 100 µM 1.36357461057401 0.0875208282544682 no 351 0.0863507437177263 408 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_646 4092-0839 27.3 µM 1.36063629118719 0.0879879694874545 no 352 0.0868143284623449 498 877796
SGTC_842 0271-0008 11.1 µM 1.3554626033313 0.0888150099460046 no 353 0.0876351077907424 549 1221709
SGTC_212 3807-4682 38.772 µM 1.35412095430139 0.0890304215647776 no 354 0.0878488960116667 675 3125501 YBL034C STU1
SGTC_996 3970-0799 1.8 µM 1.35084664244982 0.089557768668773 no 355 0.0883722816911246 675 6615648 YGL040C HEM2
SGTC_312 4092-0653 6.84 µM 1.34739744872194 0.0901157900534504 no 356 0.0889261309240882 611 1148278
SGTC_3164 9100705 49.47 µM 1.34165140302826 0.0910511327760083 no 357 0.0898545254739275 446 17174235
SGTC_306 1672-3436 11.6 µM 1.34009712545507 0.0913053714650961 no 358 0.0901068852581238 528 6797378
SGTC_1389 3405-0187 19 µM 1.33960506719146 0.0913859687624434 no 359 0.0901868877774785 475 799890
SGTC_3188 9110789 49.47 µM 1.33632320979231 0.0919248740036694 no 360 0.09072182672563 549 849217
SGTC_3026 9090633 49.47 µM 1.33546728383949 0.0920658095531464 no 361 0.0908617280438482 521 25236842
SGTC_321 4534-3890 65.3 µM 1.33541531217801 0.0920743722821839 no 362 0.090870227977308 516 699746
SGTC_314 1671-0008 2.74 µM 1.32423941356294 0.0939294121780691 no 363 0.0927117724531872 583 3913060
SGTC_1776 st049249 45.9 µM 1.32339965954915 0.0940699055424472 no 364 0.0928512524800573 555 1822314
SGTC_332 4112-0506 40.9 µM 1.32119681735009 0.0944391843611986 no 365 0.0932178736266073 535 2790355
SGTC_2214 7179297 48.276 µM 1.32095417933077 0.0944799248382529 no 366 0.093258321413619 493 769744
SGTC_714 4296-0578 26.1 µM 1.32064927985005 0.0945311377839952 no 367 0.0933091665776893 427 1589775
SGTC_3011 9081274 71.4286 µM 1.31956695998438 0.0947130966974667 no 368 0.0934898200753777 567 6625322
SGTC_2745 rifampicin 24.3 µM 1.31835228841223 0.0949176137562547 no 369 0.0936928723132541 380 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1960 st011366 51.8 µM 1.31762147815495 0.095040818629418 no 370 0.0938151959914 510 3972846
SGTC_1376 2910-0861 41.3 µM 1.31752745784946 0.0950566777486269 no 371 0.0938309417495074 572 1112859
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.31622594281883 0.0952764144626446 no 372 0.0940491093702323 558 5393153
SGTC_1440 4100-1550 40 µM 1.31350794313089 0.0957365039951858 no 373 0.0945059230624901 479 742806
SGTC_3112 9123419 49.47 µM 1.31090907535252 0.0961779541297141 no 374 0.0949442421885524 565 17015854
SGTC_1153 4055-0057 267 µM 1.30633036790409 0.0969593421570005 no 375 0.0957201171088653 543 882706
SGTC_2483 5729050 27.16 µM 1.3060911336574 0.097000296872736 no 376 0.0957607838826195 645 2865180
SGTC_1458 k015-0034 6.33 µM 1.30559433079873 0.0970853855433244 no 377 0.095845274639146 501 3598957
SGTC_78 0336-0123 156.75 µM 1.30188375732108 0.0977226379333119 no 378 0.0964780628844293 491 6765896
SGTC_920 mycophenolic acid 780.421 nM 1.30068808306017 0.0979286344180803 no 379 0.0966826214922781 551 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_932 2857-0803 154 µM 1.29911796690607 0.0981996246457133 no 380 0.0969517240277071 593 674898
SGTC_2328 6201408 200 µM 1.29762398732738 0.0984579839016987 no 381 0.0972082876387609 533 2890418
SGTC_2611 pyromycin 23.93 µM 1.29714381575596 0.0985411272927564 no 382 0.097290854009182 534 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_980 1473-0395 201 µM 1.2963234273929 0.0986832993269368 no 383 0.0974320403077727 485 768876
SGTC_126 0417-1624 672.48 µM 1.29359387620917 0.0991574069863549 no 384 0.0979028694133927 681 41912 YDL195W SEC31
SGTC_1002 4049-0206 172 µM 1.29098297676222 0.0996124621896426 no 385 0.0983547902503976 604 4662749
SGTC_2028 5153890 36.43 µM 1.28996055442314 0.0997910759578325 no 386 0.0985321770647529 545 2830968 YPR165W RHO1
SGTC_146 3448-8650 53.125 µM 1.28926402999231 0.0999128903596832 no 387 0.0986531557551016 720 2891488 YIL048W NEO1
SGTC_838 0109-0203 71.4 µM 1.28878623028144 0.0999965150105781 no 388 0.0987362071980023 565 759422
SGTC_1091 telmisartan 47.6 µM 1.28658411595716 0.100382590390793 no 389 0.0991196414950273 550 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1689 st020265 53.493 µM 1.2859394601173 0.100495817216265 no 390 0.0992320953969769 553 5758320 YPR016C TIF6
SGTC_2728 chlorpromazine 9.18 µM 1.28503617933749 0.100654625427334 no 391 0.0993898207845989 461 2726 A thorazine and dopamine antagonist.
SGTC_2386 9075165 157.42 µM 1.28191436228346 0.10120488987164 no 392 0.0999363445781058 537 16452277
SGTC_1448 4255-0083 152 µM 1.27054044791016 0.103228242767418 no 393 0.101946092257836 570 5399660
SGTC_755 1995-0008 37.3 µM 1.27002722784683 0.10332022927678 no 394 0.102037465774613 589 689533
SGTC_179 1273-0063 6.77 µM 1.26706857315195 0.103851681496547 no 395 0.10256538577093 519 3108139
SGTC_3027 9089541 49.47 µM 1.26685806072441 0.103889570486005 no 396 0.102603023543442 589 9943819
SGTC_1670 st016595 4.04 µM 1.26644422868441 0.103964083093838 no 397 0.102677042342403 571 597879
SGTC_3074 9116018 49.47 µM 1.26210376186943 0.104747942597484 no 398 0.103455725903235 521 17027303
SGTC_2194 5927483 104.545 µM 1.26105063948385 0.104938773054793 no 399 0.103645301468912 620 760979
SGTC_3324 9138759 60.749 µM 1.25934775311671 0.105247875934061 no 400 0.103952375998037 560 45595710
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.25821194290084 0.10545441074061 no 401 0.10415755846524 609 2333 A French combination drug.
SGTC_1931 st074438 57.1 µM 1.25764143657765 0.105558261679094 no 402 0.104260730305401 540 2787313
SGTC_2118 5526350 200 µM 1.25590595593124 0.105874630951429 no 403 0.104575034459706 578 743594
SGTC_2543 pimpinellin 60.67 µM 1.25355517673903 0.106304258037429 no 404 0.105001865961228 550 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_906 1165-0455 526 µM 1.25343934438611 0.106325459994268 no 405 0.105022930219603 566 3252859
SGTC_1608 st001473 40.5 µM 1.25177752777439 0.106629975197846 no 406 0.105325470435154 556 7292267
SGTC_1648 st011736 69.8 µM 1.24966222737221 0.107018497781654 no 407 0.105711480553111 572 2855514
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.24807144204593 0.10731135331879 no 408 0.106002447719221 640 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3118 9124250 49.47 µM 1.2458737653728 0.10771688425659 no 409 0.106405371439742 526 1504786
SGTC_2056 5235370 200 µM 1.24547847586338 0.10778994288447 no 410 0.106477961311404 572 5511916
SGTC_3122 9126309 49.47 µM 1.24465914625731 0.10794148756166 no 411 0.106628534574295 558 17591206
SGTC_2710 st078562 53.7235 µM 1.24338395157631 0.108177654991976 no 412 0.106863190626346 570 17250908
SGTC_596 1155-0152 116 µM 1.24242551352433 0.108355403426219 no 413 0.107039803526141 648 280313
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.24235955001984 0.108367644503279 no 414 0.107051966464542 641 16486 A toxic proline analog.
SGTC_1338 1486-1223 76 µM 1.2421818015196 0.108400634864445 no 415 0.107084746278006 630 3444526
SGTC_2128 5255449 168.493 µM 1.23901080215016 0.108990391447281 no 416 0.107670748848618 625 736008
SGTC_1185 1319-0113 81.3 µM 1.23766186385972 0.109241970983384 no 417 0.107920732664905 532 4672763
SGTC_3057 9095946 49.47 µM 1.23752544295485 0.109267436951771 no 418 0.107946037296269 580 24540043
SGTC_1407 3909-7909 12.3 µM 1.23078723581167 0.110530584230751 no 419 0.109201225354433 613 4411780
SGTC_1358 1509-0022 2.48 µM 1.22856210375216 0.110949998620707 no 420 0.109618015655891 598 3258434
SGTC_1108 betulinic acid 729.144 nM 1.22741159699946 0.11116730380844 no 421 0.109833964904792 604 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1126 isoteolin 1.0172 µM 1.22492651290499 0.11163772068809 no 422 0.110301454970875 590 133323
SGTC_2203 7227154 166.4 µM 1.22257029523053 0.112085057347661 no 423 0.110746019152751 559 896304
SGTC_3125 9127534 49.47 µM 1.22064801403369 0.112450957567171 no 424 0.111109659369161 500 1639235
SGTC_2536 dehydroabietamide 32.04 µM 1.21989111480174 0.11259526487032 no 425 0.111253077263007 651 3983547
SGTC_433 pimozide 108 µM 1.21805485271537 0.112945908617819 no 426 0.111601564385073 487 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2261 9010538 184.68 µM 1.21623587121667 0.113294020321719 no 427 0.11194754132472 516 6457250
SGTC_1659 st012954 42.1 µM 1.2150881588456 0.113514059800158 no 428 0.112166234653507 590 24207262
SGTC_579 4491-1009 110 µM 1.21369476707786 0.113781610292404 no 429 0.112432151689956 774 1271041
SGTC_1578 josamycin 24.2 µM 1.21315555082661 0.11388526779412 no 430 0.11253517732725 553 5282165 A P450 substrate.
SGTC_451 chloral hydrate 100 µM 1.2078270292294 0.114913228042951 no 431 0.113556901189171 684 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1471 k673-0312 37 µM 1.20703751109815 0.115066098810139 no 432 0.113708849124903 585 24099884
SGTC_2701 st077767 14.721 µM 1.20321208901134 0.115808845519829 no 433 0.114447128965413 668 5721188
SGTC_1728 st035614 33.7865 µM 1.20136955557423 0.116167805481869 no 434 0.114803940129862 694 15945546
SGTC_689 0833-0039 98 µM 1.20068631468654 0.116301114065818 no 435 0.114936452355869 644 5374726
SGTC_747 3448-8087 38.7 µM 1.20038887166951 0.116359182705399 no 436 0.114994174384499 640 5168703
SGTC_89 0302-0250 142.109 µM 1.17968568215176 0.12045163992688 no 437 0.11906262527501 693 4203518 YLR208W SEC13
SGTC_2101 5377231 179.231 µM 1.17894966290559 0.120598973815874 no 438 0.119209110219812 624 2844213
SGTC_3316 9136639 10.545 µM 1.17461684353185 0.121468875384197 no 439 0.120074020768758 614 4903665
SGTC_978 1416-0512 87.4 µM 1.17269227846693 0.121856682389336 no 440 0.120459614494684 687 6814003
SGTC_77 0828-0286 12.516 µM 1.17106741696692 0.122184774512084 no 441 0.120785839772673 645 745345
SGTC_1970 st070122 35.8 µM 1.16717378937715 0.122973498300314 no 442 0.121570096755269 641 102928
SGTC_3119 9125183 49.47 µM 1.16546178043045 0.123321423651205 no 443 0.121916061095099 501 22695334
SGTC_2594 a-mangostin 100 µM 1.16064228326254 0.124304574197406 no 444 0.122893701260539 680 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_365 0121-0052 13.6 µM 1.15391977362054 0.125685064513037 no 445 0.124266530789778 720 3101739
SGTC_3045 9092950 49.47 µM 1.14969610872946 0.126557860174728 no 446 0.125134528807274 709 44120432
SGTC_1903 st060211 78.3 µM 1.14949866046498 0.126598764743694 no 447 0.125175209393918 701 688960
SGTC_574 1315-0397 40 µM 1.14800218114302 0.126909083765806 no 448 0.125483831707011 755 6794277
SGTC_2572 astragaloside iv 100 µM 1.14406832388048 0.12772735635672 no 449 0.126297651522111 652 45006101 An anti-inflammatory agent.
SGTC_2375 9072683 200 µM 1.13971601627408 0.128636934681816 no 450 0.12720231616102 745 16798029
SGTC_3144 9087057 49.47 µM 1.1384396667205 0.128904526182362 no 451 0.127468469257447 654 17249618
SGTC_1928 4'-methoxychalcone 40.3 µM 1.13823247882153 0.128948000303491 no 452 0.127511709995702 690 641818
SGTC_1997 st073024 93.8 µM 1.13799556569975 0.128997724111751 no 453 0.127561166975802 660 686268
SGTC_56 0957-0365 83.25 µM 1.13731800274238 0.129140005791167 no 454 0.127702685761239 684 6752360
SGTC_18 0111-0177 500 nM 1.13633197264844 0.129347256903299 no 455 0.127908827261546 774 721752
SGTC_455 paf C-16 10 µM 1.13626886006731 0.129360530217964 no 456 0.127922029577728 649 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2932 9016711 44.54 µM 1.13587381308393 0.129443634669049 no 457 0.128004689686987 720 7117328
SGTC_3003 9075612 71.4286 µM 1.13565375892428 0.129489942619849 no 458 0.128050750174327 661 6501993
SGTC_852 0418-0143 439 µM 1.13528069777933 0.129568475410401 no 459 0.128128863517444 757 5369229
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.13180797913887 0.130301097691165 no 460 0.128857586207859 696 4213774
SGTC_531 3788-1495 174 µM 1.13038144828636 0.130602874685541 no 461 0.129157763917073 661 2896655
SGTC_266 formosanin C 406 nM 1.12963522091863 0.130760928519401 no 462 0.129314981762068 700 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1418 3966-3099 2.4 µM 1.12952459085203 0.130784371642928 no 463 0.129338300983789 698 740335
SGTC_298 1391-0729 10 µM 1.12857273010522 0.130986196233164 no 464 0.129539059904357 654 3237558
SGTC_2883 9059145 45.46 µM 1.12712663533233 0.131293225702982 no 465 0.12984447168884 636 16476510
SGTC_2145 5634607 200 µM 1.12698561787515 0.131323192578249 no 466 0.129874280898754 606 308662
SGTC_1439 4092-1168 46 µM 1.12641752706164 0.131443962393648 no 467 0.129994415710401 699 2886240
SGTC_2316 5844804 197.44 µM 1.12144731541922 0.132503844445524 no 468 0.13104875269332 820 776813
SGTC_132 0417-1715 25.805 µM 1.12119489130159 0.132557829778165 no 469 0.131102456916285 724 6769098
SGTC_25 0118-0223 35.662 µM 1.11967690059647 0.132882798321598 no 470 0.131425736013335 691 5333628
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.11919800007304 0.132985434159437 no 471 0.131527839233801 682 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2017 5132927 60.65 µM 1.11431853752122 0.134034289901856 no 472 0.132571278535126 685 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_950 1165-0508 94.1 µM 1.11416405001663 0.134067590041726 no 473 0.132604407496084 654 6148369
SGTC_2761 levamisole 97.89 µM 1.11406165080286 0.134089665561904 no 474 0.132626369564003 668 26879 An alkaline phosphatase inhibitor.
SGTC_737 1950-0117 57.9 µM 1.11190080237907 0.134556089966839 no 475 0.133090401844673 688 5393513
SGTC_305 1682-2595 20.8 µM 1.11139329849691 0.13466579722152 no 476 0.133199547824145 718 226033
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.11112593920819 0.134723617034163 no 477 0.133257072034089 757 1377
SGTC_553 k007-0256 45.7 µM 1.11107790819572 0.134734006150236 no 478 0.133267408051379 705 6287000
SGTC_545 4218-0007 221 µM 1.10740570441745 0.135529932542131 no 479 0.134059280357526 679 2840508
SGTC_1364 1653-0028 37.6 µM 1.10531493164804 0.135984530484079 no 480 0.134511575055338 709 5718652
SGTC_1952 st077036 64.1 µM 1.10529162737702 0.135989603421057 no 481 0.134516622340194 696 2937007
SGTC_2860 9025725 38.96 µM 1.1052146312712 0.136006365063551 no 482 0.134533299232611 654 40546248
SGTC_3258 9138477 49.47 µM 1.10175429683633 0.13676112180291 no 483 0.135284252269009 699 4970355
SGTC_1193 1488-0126 41.5 µM 1.10133238095169 0.136853344173575 no 484 0.135376011544155 711 1384710
SGTC_1366 1683-0113 21.9 µM 1.09939224097211 0.13727796702655 no 485 0.135798506832986 667 708623
SGTC_2218 6965428 192.983 µM 1.09911486699341 0.137338747079357 no 486 0.135858982977318 706 675684
SGTC_1076 itraconazole 331 nM 1.0949159673555 0.13826108316498 no 487 0.136776726516456 726 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1985 st071382 65.5 µM 1.09478806043146 0.138289245495791 no 488 0.136804749186983 712 6123237
SGTC_389 tpck 16.7 µM 1.09455658076993 0.138340222238828 no 489 0.136855473215673 708 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1775 st081588 35.1725 µM 1.09281395394136 0.13872439687272 no 490 0.137237746854814 745 1426443 YGL099W LSG1
SGTC_24 0417-1663 219 µM 1.09261565347546 0.138768159644721 no 491 0.137281293472316 689 4329390
SGTC_227 fluconazole 33.516 µM 1.09164206721338 0.13898315602176 no 492 0.137495229103679 759 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1490 4089-0339 670 nM 1.09147169685872 0.13902080209043 no 493 0.1375326896349 686 742542
SGTC_1234 0326-0494 15.5 µM 1.09136596518522 0.139044168693904 no 494 0.13755594110679 730 1547813
SGTC_2243 6634756 200 µM 1.08958050840703 0.139439156796574 no 495 0.137948986500749 675 885676
SGTC_674 0498-0004 451 µM 1.08928844602414 0.139503840933241 no 496 0.138013353118891 684 4231473
SGTC_1455 4262-0120 131 µM 1.07884013442768 0.141831296658282 no 497 0.140329499974011 758 1529587
SGTC_2864 9034755 47.6 µM 1.07799810274369 0.142020005174503 no 498 0.140517301410714 714 4930451
SGTC_1419 3993-2473 62.6 µM 1.07776212419687 0.142072921026922 no 499 0.140569963171756 735 704026
SGTC_830 4076-0286 57.8 µM 1.0775274135007 0.142125565812945 no 500 0.140622355282353 865 6866659
SGTC_1770 st043884 66.3 µM 1.07528261626598 0.142629732926602 no 501 0.141124108349 728 670149
SGTC_1246 0422-0085 105 µM 1.07525620258782 0.142635672459386 no 502 0.141130019504353 756 264295
SGTC_2306 7482397 179.52 µM 1.07520474764244 0.142647243396897 no 503 0.141141535163304 726 891448
SGTC_2426 5582046 32.21 µM 1.06772204208436 0.144336676890633 no 504 0.142822956284133 752 2251934
SGTC_40 0327-0103 19.753 µM 1.06754366551892 0.144377114365354 no 505 0.142863203400715 710 409036
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.06619290344347 0.144683576207507 no 506 0.143168224734679 740 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2859 9028643 45.46 µM 1.06614784001038 0.144693807777673 no 507 0.143178408277388 706 17151580
SGTC_3165 9101544 49.47 µM 1.06538172528923 0.144867827296071 no 508 0.143351611587802 742 5002184
SGTC_1587 estradiol valerate 56.1 µM 1.06500923914384 0.144952486744183 no 509 0.14343587439766 751 13791 A steroid.
SGTC_3268 9137683 49.47 µM 1.06449004034713 0.145070546915843 no 510 0.14355338192787 715 1953228
SGTC_2771 fluoxetine 41.05 µM 1.06020332078834 0.146047773215155 no 511 0.144526055342701 707 3386 A selective serotonin reuptake inhibitor.
SGTC_3132 9126706 49.47 µM 1.05973937719284 0.146153801178742 no 512 0.144631591627019 709 850858
SGTC_1342 1486-1464 234 µM 1.05939072823051 0.146233514148706 no 513 0.144710935243361 772 3253938
SGTC_743 1275-0778 158 µM 1.05689808818696 0.146804266641556 no 514 0.145279050542579 790 2849257 YMR203W TOM40
SGTC_681 1642-0006 26.6 µM 1.05183496309008 0.147968191401045 no 515 0.146437637475911 730 4446530
SGTC_2317 5986382 200 µM 1.05101778155614 0.148156624632152 no 516 0.14662521158719 791 877883
SGTC_1826 st055655 41.6 µM 1.0490422207331 0.148612830656028 no 517 0.147079343439687 764 676168
SGTC_3309 9129340 25.759 µM 1.04792924887329 0.148870256629548 no 518 0.147335602624158 803 17158987
SGTC_233 rapamycin 362 pM 1.04229540657715 0.150177911557092 no 519 0.14863737067249 794 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2524 avocatin b 10.57 µM 1.04132737727409 0.150403366496247 no 520 0.148861817390001 703 6710748
SGTC_1273 0849-0096 14.1 µM 1.03718911100468 0.15136971411086 no 521 0.149823865902819 753 5286025
SGTC_2437 5741531 144.16 µM 1.03571936528391 0.15171391337525 no 522 0.150166542612503 795 2262990
SGTC_2927 9011802 47.9 µM 1.03214919730162 0.152552174621173 no 523 0.151001114915764 724 43912568
SGTC_1848 st056003 16.4 µM 1.03197678814325 0.152592733244205 no 524 0.151041495736423 803 146492
SGTC_2253 7938677 135.83 µM 1.02990461593175 0.15308076385846 no 525 0.15152739184178 769 2301972
SGTC_5 0352-0601 109.883 µM 1.02810547099468 0.153505330246895 no 526 0.151950108696637 742 762456
SGTC_411 enrofloxacin 100 µM 1.02809005002847 0.153508972689841 no 527 0.151953735301784 790 71188 A bacterial gyrase inhibitor.
SGTC_486 niguldipine 82 µM 1.02621501185573 0.153952284630015 no 528 0.15239512343584 732 1236 A calcium channel blocker.
SGTC_1146 3579-1023 7 µM 1.02522493010392 0.154186709321244 no 529 0.152628533830994 857 X1146
SGTC_3129 9127257 49.47 µM 1.02472583896333 0.154304970119323 no 530 0.152746283735677 654 837894
SGTC_125 0133-0007 11.75 µM 1.02175428893043 0.155010327167152 no 531 0.153448604593561 851 26541
SGTC_2556 citropten 84.59 µM 1.02023197922267 0.155372501440474 no 532 0.153809227194979 852 2775 A potential DNA crosslinker.
SGTC_619 1652-1634 108 µM 1.01954851667945 0.155535286205053 no 533 0.153971316145506 720 5400454
SGTC_1829 berberine 14.4 µM 1.01688297131061 0.156171231360074 no 534 0.15460455252762 784 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2960 9079389 5.97 µM 1.01645242942422 0.15627411041897 no 535 0.154706994803398 804 16457355
SGTC_2093 5331342 194.4 µM 1.01514371071174 0.156587106068607 no 536 0.155018664033331 809 33839
SGTC_22 0964-0034 14.468 µM 1.01499542236379 0.156622597003846 no 537 0.155054004795368 814 138402
SGTC_871 0574-0004 149 µM 1.01035559688476 0.157735755209939 no 538 0.156162476694097 817 9551173
SGTC_2486 5283202 22.39 µM 1.00944455521815 0.157954935576347 no 539 0.15638073975116 741 1377751
SGTC_1627 st003713 25.6 µM 1.00918312149258 0.158017868772434 no 540 0.156443409889181 850 16195070 YER133W GLC7
SGTC_2968 9090663 33.37 µM 1.00647424316984 0.158670927788942 no 541 0.157093747786782 785 25236811
SGTC_1056 3448-1962 115 µM 1.00599124444038 0.158787555219393 no 542 0.157209890918279 757 715507
SGTC_196 k015-0023 18.111 µM 1.0028724208693 0.159541995451803 no 543 0.157961210397443 819 5211998
SGTC_703 3875-0075 71.8 µM 1.00252396692302 0.159626431577802 no 544 0.158045298551858 855 2850814
SGTC_2232 chlorophetanol 41.5365 µM 1.00230652964098 0.159679135025125 no 545 0.158097784934217 924 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2212 7123476 200 µM 0.998214882374807 0.160673010143241 no 546 0.159087585673764 715 1085715
SGTC_2906 7926292 26.41 µM 0.996978104158014 0.160974221249681 no 547 0.159387569076804 785 2966319
SGTC_311 1315-0136 58 µM 0.996813179682369 0.161014415607888 no 548 0.159427599856559 809 6759207
SGTC_3052 9092717 49.47 µM 0.995051554328259 0.161444156484768 no 549 0.159855595486216 770 25237534
SGTC_2367 9070478 135.38 µM 0.993871791105178 0.161732372389814 no 550 0.160142644647804 796 572802
SGTC_2988 9073640 71.4286 µM 0.990174176731224 0.162637869894827 no 551 0.161044496068401 765 9102229
SGTC_1205 4161-2785 76 µM 0.989181350908076 0.162881560556856 no 552 0.161287210523823 723 3498106
SGTC_1022 4477-0945 21.3 µM 0.988654686742687 0.163010927434103 no 553 0.161416060033363 792 4648966
SGTC_1019 4262-0212 3.4 µM 0.987645769182773 0.163258938854597 no 554 0.161663081277494 882 4677213
SGTC_2172 5754775 163.918 µM 0.98722087401712 0.163363459620485 no 555 0.161767185408069 729 2263357
SGTC_2818 7996756 12.99 µM 0.986954563948168 0.163428991893961 no 556 0.161832456659584 737 2241621
SGTC_26 0302-0163 425.158 µM 0.983010124467883 0.164401619156585 no 557 0.162801227872738 826 3100915
SGTC_1155 4088-0394 48.2 µM 0.980101492883542 0.16512123374953 no 558 0.163518011166556 808 2326248
SGTC_1906 st060206 94.7 µM 0.979617857672981 0.165241085694462 no 559 0.163637393341369 881 5133468
SGTC_1425 4048-4433 7.33 µM 0.974677601580682 0.166468577816343 no 560 0.164860103392402 880 23734946
SGTC_1563 conessine 56.1 µM 0.973781368272125 0.166691891732377 no 561 0.165082553021196 946 441082 An anti-amoebic, histamine inhibitor.
SGTC_258 haloperidol 50.781 µM 0.968059300082334 0.168122210454026 no 562 0.166507377384963 808 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3158 9100007 49.47 µM 0.966329405427913 0.168556174176131 no 563 0.166939688193166 759 19297233
SGTC_1957 st077035 62.4 µM 0.965109583002494 0.168862613025459 no 564 0.167244963790389 860 705593
SGTC_678 1218-2179 85.9 µM 0.963663728627796 0.169226297968914 no 565 0.167607272391649 826 6820081 YOR116C RPO31
SGTC_3303 9125618 40.5795 µM 0.96358268905828 0.169246697239027 no 566 0.167627594597457 896 22695467
SGTC_1212 0520-0165 585 µM 0.962269523548675 0.169577467118888 no 567 0.167957116900557 809 5403258
SGTC_2239 6685329 187.64 µM 0.96192968630934 0.169663135353218 no 568 0.168042462632093 819 805680
SGTC_176 1486-1328 72.834 µM 0.961831384487119 0.169687921048848 no 569 0.168067155067771 854 22310231
SGTC_2958 9077254 16.72 µM 0.96132215196959 0.169816355459388 no 570 0.16819510656319 799 16457351
SGTC_2468 5987765 72.9 µM 0.957547774768375 0.170770240150703 no 571 0.169145422375546 889 26772094
SGTC_738 1315-0003 72.4 µM 0.956671067497115 0.170992297037552 no 572 0.169366652930885 859 6251474
SGTC_2726 cimetidine 79.27 µM 0.956100126159739 0.171137007239704 no 573 0.169510825536008 793 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.954932584948846 0.17143317479206 no 574 0.169805895057992 822 6710655
SGTC_2982 9019404 25.97 µM 0.953702379521787 0.171745592443958 no 575 0.170117157674215 720 22333232
SGTC_3321 9137793 26.8275 µM 0.952470509782289 0.17205879691421 no 576 0.170429207534325 855 4904192
SGTC_2445 5742597 35.57 µM 0.95054029353761 0.172550289594227 no 577 0.170918895070737 810 1774255
SGTC_2683 piperine 63.03 µM 0.948885401693278 0.172972388284753 no 578 0.171339450018771 825 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_626 0214-0009 33 µM 0.948680869633658 0.173024602116657 no 579 0.171391473307646 889 3437874
SGTC_3216 9129716 49.47 µM 0.947368883073854 0.173359770484387 no 580 0.171725420743144 783 8056934
SGTC_2405 ticlatone 3.52 µM 0.946587401182853 0.17355960907233 no 581 0.171924533173295 878 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2889 9059656 51.95 µM 0.946246600308739 0.173646803702137 no 582 0.172011411383611 898 3949838
SGTC_2010 4012422 159 µM 0.946115018840352 0.173680476557762 no 583 0.17204496211274 847 952393
SGTC_3039 9090270 49.47 µM 0.945809881455251 0.173758579885486 no 584 0.172122782318062 826 17173750
SGTC_161 4065-0411 162.148 µM 0.945359444202836 0.173873915165511 no 585 0.172237699886097 880 1906281 YLR208W SEC13
SGTC_1284 0929-0043 16 µM 0.944205068617254 0.174169717346521 no 586 0.172532432798056 861 1239883
SGTC_929 2805-0021 398 µM 0.93982675685791 0.17529453964872 no 587 0.173653215849336 846 3098024
SGTC_1725 st036284 20.55 µM 0.939160376989166 0.175466140819698 no 588 0.173824204513849 938 707914
SGTC_872 0588-0139 234 µM 0.938479725339976 0.175641527039726 no 589 0.173998965730725 883 2047100
SGTC_1225 1216-0074 20.6 µM 0.936415448941104 0.176174116360108 no 590 0.174529663394559 877 4241466
SGTC_82 0054-0107 293.755 µM 0.935515134935668 0.176406719778181 no 591 0.174761443603219 885 3104697
SGTC_1701 st028638 40.4 µM 0.934486718359476 0.176672657137656 no 592 0.175026441976797 897 3490878
SGTC_2355 9061122 103.12 µM 0.93350440539893 0.176926909170124 no 593 0.175279798470143 876 5302957
SGTC_811 0416-0114 265 µM 0.929833816042477 0.177879012664972 no 594 0.176228567363545 857 6612453
SGTC_3091 9116372 49.47 µM 0.92854728962034 0.178213484391467 no 595 0.176561874729502 829 17169793
SGTC_1828 st055811 49 µM 0.927131444661621 0.178582034243247 no 596 0.176929145836091 849 5877589
SGTC_2919 7978188 46.38 µM 0.92686325823425 0.178651898228401 no 597 0.176998767917927 898 2980291
SGTC_2233 sulbentine 40.3845 µM 0.926433541815267 0.178763877508058 no 598 0.177110359803509 920 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3319 9138450 16.7555 µM 0.925651446070433 0.178967796254969 no 599 0.177313574143039 836 2029690
SGTC_629 3448-6466 76.7 µM 0.923434447993928 0.179546637624662 no 600 0.177890423382309 901 573744
SGTC_2142 5622915 118.518 µM 0.923355346523465 0.179567312135515 no 601 0.177911026942036 847 5322196
SGTC_274 sirtinol 40.1 µM 0.921599855038796 0.180026524614618 no 602 0.178368667070995 876 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2192 5915882 198.485 µM 0.92156829455498 0.180034787145639 no 603 0.178376901373731 860 2876149
SGTC_1476 4112-3294 3.34 µM 0.92152777839077 0.180045394621781 no 604 0.178387472613516 908 704369
SGTC_690 glyoxal 20.3 µM 0.919464106989768 0.180586200260651 no 605 0.17892643563266 853 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2910 7948405 25.97 µM 0.919133469694545 0.180672941647044 no 606 0.179012882357354 851 2971328
SGTC_2387 9077560 195.08 µM 0.917820742374768 0.181017588174744 no 607 0.179356360519087 866 5303272
SGTC_587 k089-0003 57 µM 0.917345748485922 0.181142395617576 no 608 0.17948074580558 782 9659696
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.917077369370653 0.181212937638057 no 609 0.179551049442693 826 2374 Ca(2+)-ATPase inhibitor.
SGTC_860 0443-0016 25.1 µM 0.914957806392179 0.181770657841398 no 610 0.180106890580584 953 5337942
SGTC_1984 st072354 53.1 µM 0.914630812274712 0.181856795252057 no 611 0.180192738670089 888 5762938
SGTC_1703 st026983 48.3 µM 0.914330234974896 0.181935996410974 no 612 0.180271674015933 932 1104023
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.913788418729382 0.182078817739217 no 613 0.180414016519708 888 97141
SGTC_960 1222-0186 7.7 µM 0.913038453228305 0.182276622280616 no 614 0.180611158980242 898 3126296
SGTC_1375 2910-0797 186 µM 0.912930319804843 0.182305153708402 no 615 0.180639595012679 880 742508
SGTC_1260 0700-1617 7.75 µM 0.911133774965186 0.182779587379802 no 616 0.181112446227281 892 2853078
SGTC_3345 9148410 3.559 µM 0.909520133110361 0.183206376222702 no 617 0.181537817679181 898 4903596
SGTC_93 0109-0045 59.227 µM 0.906696820611005 0.18395460203768 no 618 0.182283572602661 1055 88733
SGTC_331 k048-0133 24.5 µM 0.906651645522499 0.183966589650481 no 619 0.182295520773275 857 6813582
SGTC_1666 st014829 29 µM 0.905758431790987 0.184203711767739 no 620 0.182531863638167 929 3858230
SGTC_2227 7312221 64.1025 µM 0.904745021274165 0.184472972838514 no 621 0.182800242000773 929 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_662 k832-1615 104 µM 0.902222732045774 0.1851442021124 no 622 0.183469280798798 881 5878478
SGTC_1460 k062-0059 9.15 µM 0.902032316050144 0.185194936951505 no 623 0.183519850649419 873 1373085
SGTC_2041 5107442 45.335 µM 0.90041173297209 0.185627077900191 no 624 0.183950589575108 923 793005
SGTC_2743 auranofin 4.32 µM 0.900352126492247 0.185642984347342 no 625 0.183966444528168 888 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_188 3229-0966 278.469 µM 0.899039980925917 0.185993354668072 no 626 0.184315682609781 1026 5722370
SGTC_476 mead acid 10 µM 0.896565924846852 0.186655093795989 no 627 0.184975293806982 889 5312531 An omega 9 fatty acid.
SGTC_2897 9048598 12.99 µM 0.896034605688572 0.186797396354549 no 628 0.185117140560431 886 6467404
SGTC_928 2764-0428 58.7 µM 0.895933171859499 0.186824570883799 no 629 0.185144228119778 935 662578
SGTC_775 4577-0580 57.3 µM 0.895396437445634 0.186968404906151 no 630 0.185287602197333 922 2006902
SGTC_2234 tolnaftate 200 µM 0.893903034371632 0.187368967263494 no 631 0.185686887062628 899 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2417 cerulenin 830 nM 0.893862884302213 0.187379743680861 no 632 0.185697629180492 899 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2709 st078560 56 µM 0.893374036240716 0.187510982918967 no 633 0.185828450996874 930 17250903
SGTC_3072 9116419 49.47 µM 0.893322902242591 0.187524713955957 no 634 0.18584213839171 865 17170162
SGTC_1071 trifluoperazine 6.31 µM 0.893015408273925 0.187607298561059 no 635 0.185924460637223 941 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2463 5473429 200 µM 0.891775122211944 0.187940634080509 no 636 0.186256739354358 890 5399405
SGTC_1765 st044815 90.4 µM 0.891165584307841 0.188104585567289 no 637 0.186420172319001 901 645695
SGTC_1348 1493-0373 93.8 µM 0.890530351637844 0.18827554224964 no 638 0.186590589213147 913 3010129
SGTC_904 1141-0088 396 µM 0.890375715365751 0.188317173164384 no 639 0.186632088817427 891 1378119
SGTC_1206 3978-0017 132 µM 0.883596360617385 0.190147877867269 no 640 0.188457072179247 886 3873677
SGTC_1484 3473-2379 286 µM 0.880893159515731 0.190880892721599 no 641 0.18918782512412 1119 671917
SGTC_1352 1496-0991 99 µM 0.880030870786867 0.191115079881482 no 642 0.189421293106348 933 3000039
SGTC_355 1311-2252 105 µM 0.875782880976531 0.192271352232173 no 643 0.190574039124961 898 5338538
SGTC_3007 9078383 71.4286 µM 0.875176182258986 0.192436839756769 no 644 0.190739025282915 938 6496995
SGTC_385 1494-0393 12.4 µM 0.873175885445557 0.192983071771985 no 645 0.191283608309852 951 3090647
SGTC_261 5-fluorouridine 15.376 µM 0.871668781997051 0.193395249560611 no 646 0.191694547776929 932 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2589 lobaric acid 100 µM 0.871009286696698 0.193575783778716 no 647 0.191874541225266 924 73157 A novel microtubule depolymerizer.
SGTC_3235 9132602 49.47 µM 0.870705979975091 0.193658847282943 no 648 0.191957356252489 953 4912240
SGTC_2349 9023730 187.07 µM 0.870000907462549 0.193852022236312 no 649 0.192149954144706 936 4126287
SGTC_2338 7999974 200 µM 0.866821079284526 0.194724686246823 no 650 0.193020025284995 1031 315925
SGTC_1125 tnp00248 1.32998 µM 0.864812083974684 0.195277259754515 no 651 0.193570968793457 1082 24207736
SGTC_291 SEC14.278 35.5 µM 0.864617118084605 0.195330935729606 no 652 0.193624486920319 987 1068044
SGTC_1936 st074407 74.3 µM 0.864490011826119 0.195365934125032 no 653 0.193659382440204 1007 809813
SGTC_2339 9000433 200 µM 0.863263757412113 0.195703775879983 no 654 0.1939962330122 874 2988954
SGTC_2874 9043904 71.43 µM 0.860766475576583 0.196392890316712 no 655 0.194683336228543 860 4463428
SGTC_1882 5615643 20 µM 0.860151097091508 0.196562927018877 no 656 0.194852878842094 931 2253075
SGTC_3008 9078912 71.4286 µM 0.859951018981563 0.196618230289195 no 657 0.194908021598588 935 16648731
SGTC_711 k292-0785 179 µM 0.85994411500111 0.196620138775615 no 658 0.194909924547383 1001 4146315
SGTC_36 0335-0881 14.2 µM 0.858091917987644 0.197132552004624 no 659 0.195420854877849 974 23828853
SGTC_1316 1272-0050 65.9 µM 0.856704475734551 0.197516918942147 no 660 0.195804114581544 956 7340392
SGTC_2977 9011197 71.43 µM 0.855563115652309 0.197833452491138 no 661 0.19611973958125 888 2704722
SGTC_1927 st060202 13.8 µM 0.854172398144019 0.198219554316785 no 662 0.196504737177271 969 688887
SGTC_2603 homopterocarpin 100 µM 0.853212021101107 0.198486446993862 no 663 0.196770869123001 958 101795 A weak amylase inhibitor.
SGTC_1705 st027868 56.3335 µM 0.852761168152722 0.198611815599037 no 664 0.196895881110003 997 292948
SGTC_2841 9004761 38.96 µM 0.85147841132976 0.198968772730297 no 665 0.197251825385395 933 2991039
SGTC_1988 st071872 53.4 µM 0.848652138626954 0.199756612414072 no 666 0.198037442816456 992 16414116
SGTC_2994 9053520 71.4286 µM 0.848633972337281 0.199761682433524 no 667 0.198042498593759 972 4647384
SGTC_1363 1636-0063 10.4 µM 0.848548261032823 0.199785604596947 no 668 0.198066353567764 1002 6072185
SGTC_1888 azatryptophan 97.5 µM 0.847454876504429 0.200090921162419 no 669 0.19837081406806 886 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_43 0570-0105 72.5 µM 0.846799591074491 0.200274037330899 no 670 0.198553418109057 1011 1114046 YDL195W SEC31
SGTC_555 4296-0685 37 µM 0.846720790400294 0.20029606455757 no 671 0.198575383797267 995 2908540 YHR072W ERG7
SGTC_2264 7948757 110.76 µM 0.845851093220427 0.200539268503118 no 672 0.198817909232428 962 2971411
SGTC_122 0236-0016 402.397 µM 0.845665994013479 0.200591052912128 no 673 0.1988695493914 1072 6808838
SGTC_2202 7226349 200 µM 0.845465905869609 0.200647039741325 no 674 0.198925380352129 950 844334
SGTC_2842 9000675 19.48 µM 0.843107315939229 0.201307705566897 no 675 0.199584213749903 933 2989072
SGTC_3075 9116269 49.47 µM 0.842328585004039 0.201526122319991 no 676 0.199802027485992 972 17015205 YNL244C SUI1
SGTC_3302 9125395 16.351 µM 0.840729764795718 0.201975000714134 no 677 0.200249670927505 949 17599668
SGTC_3297 9117502 71.43 µM 0.840124346234883 0.202145131711915 no 678 0.200419335383688 993 7453720
SGTC_1100 amiodarone 5.07 µM 0.837729559217467 0.202818939957687 no 679 0.201091304080888 1034 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1987 st072290 61.9 µM 0.835991058402323 0.203308932062462 no 680 0.201579966675695 1010 54697379
SGTC_1972 st070201 17.4 µM 0.833312036190545 0.204065389313401 no 681 0.202334384934385 995 2829099
SGTC_181 1447-1644 8.07 µM 0.832139957023386 0.204396867880968 no 682 0.202664975177787 988 534600
SGTC_481 bay k-8644 50 µM 0.830832034508019 0.20476714277783 no 683 0.203034261489422 933 2303 A calcium channel antagonist.
SGTC_1514 1189-1591 158 µM 0.830773747163318 0.204783653296171 no 684 0.203050728017889 1001 767698 YMR146C TIF34
SGTC_1796 st049173 110.4 µM 0.83037973124608 0.204895283314208 no 685 0.203162060817736 953 94134
SGTC_2497 7-hydroxyflavone 100 µM 0.829842873367601 0.205047440604689 no 686 0.203313813556418 934 5281894
SGTC_1711 st032263 62.8 µM 0.829575494331072 0.2051232467322 no 687 0.203389418378489 967 3958979
SGTC_472 calcifediol 10 µM 0.82860858506263 0.205397519574094 no 688 0.203662964245764 933 5283731 A vitamin D metabolite.
SGTC_2838 9002687 71.43 µM 0.827966226615321 0.205579850898069 no 689 0.203844813473567 932 6457060
SGTC_2091 4-phenylthiadiazole 200 µM 0.82738968944172 0.205743580864573 no 690 0.204008111331169 1011 270010
SGTC_2245 6637752 200 µM 0.826014384734105 0.206134464014889 no 691 0.204397965952524 948 681890
SGTC_2996 9066192 71.4286 µM 0.82458357232249 0.20654159027571 no 692 0.204804025541439 1011 6472854
SGTC_3356 9151811 4.48 µM 0.820571407205351 0.207685757334893 no 693 0.205945219916802 989 1859254 YPR165W RHO1
SGTC_1695 st026914 34.495 µM 0.820258553907476 0.207775132208069 no 694 0.206034364134255 983 3289191
SGTC_1612 st002233 45.4 µM 0.819982546730571 0.207853999864366 no 695 0.206113028437774 1031 1035021
SGTC_992 3909-8734 162 µM 0.817614861052792 0.208531280075484 no 696 0.206788569525254 1009 4288319
SGTC_2849 9019321 12.99 µM 0.816936081529043 0.208725685754661 no 697 0.206982478380428 951 16489627
SGTC_51 1013-0126 23.419 µM 0.815318487952436 0.209189402589234 no 698 0.207445014400546 984 1627850
SGTC_3 0833-0587 95.581 µM 0.813217137815016 0.209792703116546 no 699 0.208046787647977 1000 5382644
SGTC_2465 5809242 33.21 µM 0.81291302687827 0.209880098435916 no 700 0.208133962562302 1039 2731748
SGTC_1400 3771-8998 51.5 µM 0.812679165772939 0.209947319930391 no 701 0.20820101467316 986 670767
SGTC_2812 7970281 58.44 µM 0.811869102767038 0.210180263827005 no 702 0.208433372572513 1028 2233435
SGTC_1696 st025591 34.7925 µM 0.810915457285603 0.210454691147602 no 703 0.208707111471164 1036 2787147
SGTC_945 3381-0768 11.3 µM 0.810559812205097 0.210557087743623 no 704 0.20880925173226 1069 1126236 YIL048W NEO1
SGTC_315 k915-0449 187 µM 0.809244467330305 0.210936053060602 no 705 0.209187270890088 1070 20970215 YNL149C PGA2
SGTC_2624 nerol 100 µM 0.808036870342276 0.211284326883474 no 706 0.209534678682344 1007 637566 A natural product oil.
SGTC_3238 9133470 49.47 µM 0.807655350903884 0.211394427978285 no 707 0.209644506692421 1035 3534688
SGTC_3179 9107801 49.47 µM 0.807376691091099 0.211474866475906 no 708 0.209724745889124 1061 4818259
SGTC_3135 9127742 49.47 µM 0.807111839165646 0.211551335771725 no 709 0.209801025883875 950 3643468
SGTC_2937 9044753 11.33 µM 0.802587327451572 0.212860172680993 no 710 0.211106647685096 1089 6465530 YGL099W LSG1
SGTC_279 1273-0055 2.93 µM 0.802403992145142 0.212913306803109 no 711 0.211159652278412 1113 2847562
SGTC_2762 leflunomide 42.06 µM 0.801992393767705 0.21303262417524 no 712 0.211278679063881 1037 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1837 st055472 66.5 µM 0.801968254774044 0.213039622987241 no 713 0.211285660843009 1040 676091
SGTC_2954 9074818 52.69 µM 0.800561586924054 0.213447701103158 no 714 0.211692748143587 1008 16648742
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.799511647416798 0.213752588091801 no 715 0.211996897834706 1051 688798
SGTC_2970 9090938 41.86 µM 0.798421214532429 0.214069502110033 no 716 0.212313048158275 1078 17217104
SGTC_868 0527-0199 213 µM 0.797538188545511 0.214326337441029 no 717 0.212569266578162 1007 2849450
SGTC_1664 st014217 9.02 µM 0.797006653618423 0.214481025097602 no 718 0.212723583545341 1140 3982782
SGTC_2652 actinonin 100 µM 0.796505752391926 0.214626857104806 no 719 0.21286906668022 1027 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2113 5491891 107.031 µM 0.794604538336862 0.215180899377161 no 720 0.213421788786151 1096 789979
SGTC_1503 4585-0012 61.3 µM 0.794185586953498 0.215303099620073 no 721 0.213543698971671 1047 2922052
SGTC_2759 disulfiram 3.38 µM 0.79398118090717 0.215362735635188 no 722 0.213603193580146 1040 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2280 7785178 200 µM 0.792522593547954 0.215788560537875 no 723 0.214028011579235 1011 2954328
SGTC_3204 9114183 49.47 µM 0.789993338418686 0.216528115447265 no 724 0.214765829375677 1006 17027248
SGTC_2902 5787006 60.46 µM 0.789586422144678 0.216647234676248 no 725 0.214884670188001 1017 591003
SGTC_3049 9092223 49.47 µM 0.789113052425225 0.216785854935268 no 726 0.215022966931321 1006 8623917
SGTC_1616 st002734 56.1 µM 0.788253389246308 0.217037727382504 no 727 0.215274252873817 1049 4026101
SGTC_696 1560-0013 611 µM 0.787755118580166 0.217183792931052 no 728 0.215419979077881 1066 1650269
SGTC_2629 bisabolol 100 µM 0.787744679597903 0.21718685367357 no 729 0.215423032715702 1058 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1047 2043-3044 82 µM 0.787008332496244 0.217402815826951 no 730 0.215638494205113 1109 669592
SGTC_189 3970-0742 2.116 µM 0.783584051700782 0.218408745616787 no 731 0.216642108408448 1074 2891807
SGTC_839 0122-0028 230 µM 0.781076945330884 0.219146939603804 no 732 0.217378620303939 1077 759448
SGTC_441 propafenone 146 µM 0.781070023713696 0.219148979592762 no 733 0.21738065566456 1070 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_484 loperamide 105 µM 0.77954156539156 0.219599725187636 no 734 0.217830381317184 1013 3955 An opioid-receptor agonist.
SGTC_876 0720-0963 56.8 µM 0.779349671736146 0.219656352627605 no 735 0.217886881002617 1092 765861
SGTC_2783 7738165 71.43 µM 0.777752905980864 0.220127880123107 no 736 0.218357348007949 992 17201110
SGTC_1326 1431-2094 10.8 µM 0.777660486113974 0.220155189620824 no 737 0.21838459626559 1069 616278
SGTC_2760 etidronate 98.04 µM 0.776623875924244 0.220461634604137 no 738 0.218690355415417 1098 3305 A chelator and antioxidant.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.776283755901868 0.220562234870958 no 739 0.21879073107697 1157 65057 A dermal irritant. YDR527W RBA50
SGTC_2487 5918373 44.05 µM 0.776087203031645 0.220620383018212 no 740 0.218848749521647 1125 2876279
SGTC_2403 6032726 181.2 µM 0.775835554027916 0.220694843608789 no 741 0.218923044154245 1058 2881040
SGTC_2342 7990637 118.86 µM 0.773842743845158 0.221285005638452 no 742 0.219511896002489 1091 2033102 YER133W GLC7
SGTC_597 k018-0003 82.8 µM 0.773480195145075 0.221392469813226 no 743 0.219619122590484 1163 6786234
SGTC_3242 9133940 49.47 µM 0.772750064803922 0.221608980529913 no 744 0.219835155558014 1137 17248444
SGTC_631 k072-0230 41.5 µM 0.771161645527383 0.222080423481568 no 745 0.220305562492502 1098 5773147
SGTC_2680 butyl paraben 22.24 µM 0.770197835074497 0.222366761349314 no 746 0.220591273966566 1106 7184 An antifungal and steroid mimetic.
SGTC_2287 7945887 168.79 µM 0.769565031345491 0.222554875098584 no 747 0.220778977366803 1106 1245853
SGTC_719 2810-4230 27.3 µM 0.76821804929926 0.22295559481969 no 748 0.221178826049834 1068 721079
SGTC_544 k015-0020 52.4 µM 0.767933424851806 0.223040321586534 no 749 0.221263369185007 1064 3008304
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.767711470647669 0.223106405450476 no 750 0.221329309952922 1115 688761
SGTC_1782 st039423 80.636 µM 0.767440095688299 0.22318721882263 no 751 0.221409948489177 1024 2068169
SGTC_1195 1502-0147 41.1 µM 0.766542927923451 0.223454507050688 no 752 0.221676659665634 1121 817940
SGTC_2052 5265182 7.135 µM 0.766317380622921 0.223521731744351 no 753 0.221743739520316 1085 1239884
SGTC_3016 9080866 49.47 µM 0.764849134142136 0.223959625777633 no 754 0.22218069296921 1117 17066299
SGTC_1720 st037298 9.481 µM 0.763991459424058 0.224215646505109 no 755 0.22243616608193 1055 597396
SGTC_1947 st076332 61.6 µM 0.763974087737766 0.224220833767708 no 756 0.222441342266854 1088 24208416
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.763640955173927 0.224320321811569 no 757 0.22254061798395 1071 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1216 1165-0504 9.65 µM 0.763628467870559 0.224324051557101 no 758 0.222544339774482 1091 6304004
SGTC_1852 st056254 31.4 µM 0.763081358432141 0.224487498415037 no 759 0.222707438378823 1055 442583
SGTC_3036 9090181 49.47 µM 0.762739267770505 0.224589731023215 no 760 0.222809453513991 1090 25236586
SGTC_2015 5119600 184 µM 0.762491621630844 0.224663755691379 no 761 0.222883320883303 1092 2828786
SGTC_1574 spiramycin 23.7 µM 0.760482803055845 0.225264728996206 no 762 0.223483022402532 1122 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2089 5281248 129.67 µM 0.76045293828106 0.22527367043044 no 763 0.223491944985372 1078 2737878
SGTC_1192 1488-0095 21.4 µM 0.759732584243683 0.22548940340193 no 764 0.223707223749264 1058 915875
SGTC_463 ikarugamyin 104 µM 0.758951246863463 0.225723531932221 no 765 0.223940860701677 1118 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2789 5281112 71.43 µM 0.758488955614114 0.22586212269874 no 766 0.224079161148475 1088 765948
SGTC_2332 7982454 138.89 µM 0.757403770932953 0.226187640310685 no 767 0.224403998813612 1081 2981748
SGTC_2965 9082772 38.63 µM 0.755406003893981 0.226787593505379 no 768 0.225002705959835 1131 16459634
SGTC_843 0310-0051 143 µM 0.755381316615086 0.226795013000497 no 769 0.225010110103234 1109 2065037
SGTC_2769 toremifene 3.73 µM 0.755206325186324 0.226847608710613 no 770 0.225062597027792 1092 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2400 5203494 178.7 µM 0.753781696562369 0.227276053362465 no 771 0.225490158156 1072 6777674
SGTC_2423 st077119 87.2 µM 0.752261115793891 0.227733857456813 no 772 0.225947023379385 1107 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_919 tnp00227 403.569 nM 0.750588499042827 0.228238034251715 no 773 0.226450172400733 1107 1269246 A methoxyflavone. YNL221C POP1
SGTC_3126 9127922 49.47 µM 0.750476397361384 0.228271847478021 no 774 0.226483916930328 1138 45595682
SGTC_2687 chenodiol 100 µM 0.74934056867228 0.228614606202378 no 775 0.226825980933347 1083 5702181 A cholesterol synthesis inhibitor.
SGTC_3308 9128332 17.569 µM 0.748443526301574 0.228885510599108 no 776 0.227096338363697 1135 17332805 YDL196W YDL196W
SGTC_1050 3232-1156 69.3 µM 0.745620588911416 0.229739204657441 no 777 0.227948320978991 1073 700529
SGTC_3182 9108849 49.47 µM 0.744794730565567 0.229989292000602 no 778 0.228197910459641 1155 17133045
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.744361626554571 0.230120505917385 no 779 0.228328863794937 1181 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2534 helenine 20.12 µM 0.743629874963989 0.230342293734996 no 780 0.228550212147727 1107 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_908 3448-7491 47.7 µM 0.742568779897378 0.230664115036232 no 781 0.22887139798121 1154 1203031
SGTC_2325 6158266 200 µM 0.741996367066059 0.230837827339324 no 782 0.229044768358524 1138 3623240
SGTC_3272 9137413 49.47 µM 0.74134019368282 0.231037048620372 no 783 0.229243598439873 1112 17614870
SGTC_1916 st067606 49.2 µM 0.740589422134661 0.231265108591178 no 784 0.22947121180933 1155 19590279
SGTC_2071 5230951 39.92 µM 0.740326039971397 0.231345145269381 no 785 0.229551092065021 1187 1799272
SGTC_2153 5569715 200 µM 0.739310519409382 0.23165388663831 no 786 0.229859231543553 1111 2054701
SGTC_2706 st078239 82.5 µM 0.73912452035599 0.231710459453923 no 787 0.229915694330311 1146 15434492
SGTC_1109 tnp00067 928.257 nM 0.737097134889702 0.232327600882442 no 788 0.230531640693002 1117 676295
SGTC_3296 9122258 64.045 µM 0.736929266361739 0.232378741460723 no 789 0.230582682668271 1121 4730474
SGTC_2370 9071495 200 µM 0.735463360540675 0.232825590694743 no 790 0.231028673126679 1079 21791103
SGTC_2441 5730946 39.09 µM 0.734115756470647 0.233236799064559 no 791 0.231439095626332 1137 1774275
SGTC_663 1486-0733 13.9 µM 0.732448855558404 0.233745994975044 no 792 0.231947324245124 1114 722445 YPR165W RHO1
SGTC_1020 4335-0961 93.3 µM 0.732340105998998 0.233779236602555 no 793 0.231980502949888 1048 669075
SGTC_3225 9130819 49.47 µM 0.732254471338507 0.233805414510942 no 794 0.232006631325727 1130 4547121
SGTC_66 0109-0187 42.4 µM 0.731971371200117 0.233891967777212 no 795 0.232093020941558 1072 759417
SGTC_2224 6650123 117.647 µM 0.730699235458189 0.234281121655377 no 796 0.232481441329063 1110 2908370
SGTC_2479 5617353 43.85 µM 0.729753560090608 0.234570641450034 no 797 0.232770417866745 1146 2731746
SGTC_1941 st076221 61.8 µM 0.729155852524012 0.234753732448424 no 798 0.232953166385049 1160 2828568
SGTC_3134 9127454 49.47 µM 0.728958163056755 0.234814306470966 no 799 0.23301362728402 1214 24262820
SGTC_2776 terbinafine 19.92 µM 0.727733913938671 0.235189620954431 no 800 0.233388242883354 1170 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2517 totarol 10 µM 0.726546956856008 0.235553818990036 no 801 0.23375176606579 1115 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2570 licareol 100 µM 0.725914595621972 0.235747975480755 no 802 0.233945564126441 1097 443158
SGTC_19 0279-0214 38.434 µM 0.725878926051387 0.235758929885473 no 803 0.233956498336084 1223 3566274 YBR002C RER2
SGTC_2930 9013230 14.89 µM 0.725797220997849 0.235784023205603 no 804 0.233981545406393 1132 2995857
SGTC_2855 9016525 58.44 µM 0.725671456048457 0.23582265111325 no 805 0.234020102148806 1192 43811474
SGTC_3046 9092212 49.47 µM 0.724917408122764 0.236054325310925 no 806 0.234251350298925 1167 25236637
SGTC_1291 0993-0025 5.79 µM 0.723623882903284 0.236452040788545 no 807 0.234648337463133 1156 4353356
SGTC_905 2-aminofluorene 215 µM 0.722848374495525 0.236690660258986 no 808 0.234886521831361 1212 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3101 9120531 49.47 µM 0.722793310021721 0.236707608315441 no 809 0.234903439037714 1176 24824904
SGTC_1098 clofazimine 15.1 µM 0.722493075700371 0.236800027880602 no 810 0.234995690498129 1161 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_953 1188-0045 9.7 µM 0.721738091774899 0.237032518306625 no 811 0.235227758967691 1155 6144426
SGTC_2823 7987624 58.44 µM 0.721468892343528 0.237115446149268 no 812 0.235310536622123 1162 2239440
SGTC_734 2023-0417 80 µM 0.721140560978588 0.237216611368982 no 813 0.235411518852819 1121 3935732
SGTC_1224 0823-0416 294 µM 0.719379128129308 0.237759747344015 no 814 0.235953676682906 1163 3598164
SGTC_2297 7971671 152.32 µM 0.719151060663727 0.237830121552407 no 815 0.236023924681258 1158 909016
SGTC_688 0527-0193 473 µM 0.717796987784445 0.238248179598784 no 816 0.236441235471812 1134 4007154
SGTC_1136 pergolide 1.05886 µM 0.71621573887525 0.238736885352113 no 817 0.236929073097522 1122 47811 A dopamine receptor agonist.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.712700288907701 0.239825343722636 no 818 0.238015618837729 1202 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2304 7443016 91.4 µM 0.711742130332555 0.240122478879554 no 819 0.238312236866839 1101 939854
SGTC_2065 5221596 34.26 µM 0.711034708596898 0.240341986587334 no 820 0.238531363920926 1137 788581
SGTC_1447 4239-0816 81.9 µM 0.711016976245601 0.240347490208248 no 821 0.238536858012857 1151 1341554
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.710652820179054 0.240460529145307 no 822 0.23864970139604 1176 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1410 3909-8106 77.9 µM 0.710398846577186 0.240539383099558 no 823 0.238728419118289 1191 1039210
SGTC_1980 st071811 45.7 µM 0.708898357482363 0.241005543507832 no 824 0.239193777232934 1210 4974850
SGTC_2805 7950783 58.44 µM 0.706677649423732 0.241696356658938 no 825 0.239883411083009 1166 1178958 YDL195W SEC31
SGTC_23 0213-0011 39.996 µM 0.705169938012037 0.242165984228245 no 826 0.240352243496233 1186 627608
SGTC_1671 st016596 74.5 µM 0.705137633597297 0.242176051938163 no 827 0.240362294217865 1228 2829167
SGTC_1250 0485-0349 40.2 µM 0.704673972037174 0.242320577620975 no 828 0.240506576295603 1175 6842794 YDL195W SEC31
SGTC_1573 oleylamine 1.06 µM 0.70439537767471 0.242407439384349 no 829 0.240593291890282 1196 5356789 An amine of the fatty acid oleic acid.
SGTC_1474 0330-0125 5.35 µM 0.70404181424298 0.24251769972266 no 830 0.240703366945919 1191 X1474
SGTC_2289 7946404 165.07 µM 0.703294686873514 0.242750784056202 no 831 0.240936060560697 1240 1246120 YPR165W RHO1
SGTC_2164 5685496 200 µM 0.700671260011147 0.243570184637592 no 832 0.241754097896779 1185 759046
SGTC_2399 5884133 200 µM 0.698183391640678 0.24434862282916 no 833 0.242531255829793 1215 722445
SGTC_2808 7946468 45.46 µM 0.697725818154066 0.244491940503196 no 834 0.242674339368344 1183 2970879
SGTC_1949 st076024 69.1 µM 0.697625802545145 0.244523272658629 no 835 0.242705620402032 1187 2921930
SGTC_786 4544-0069 423 µM 0.697539655273258 0.244550261977091 no 836 0.242732565703249 1185 748821 YLR208W SEC13
SGTC_283 0987-0079 11.7 µM 0.697060610451245 0.244700372528132 no 837 0.242882431752691 1217 411556
SGTC_1737 st035557 69.7 µM 0.696264772833224 0.244949860961592 no 838 0.243131515000172 1077 5716916
SGTC_1626 st003712 1.76 µM 0.695816916037255 0.245090320479479 no 839 0.243271747051983 1166 24207035
SGTC_2301 7769476 200 µM 0.694921315120901 0.245371334062608 no 840 0.243552306953268 1177 977820
SGTC_1433 4060-0023 7.6 µM 0.694862943569676 0.245389655370861 no 841 0.243570598747663 1203 3840627
SGTC_657 3534-0529 86.7 µM 0.694139335993665 0.245616837960727 no 842 0.243797416028309 1212 1049549
SGTC_1991 st073000 8.92 µM 0.692491262591052 0.246134685605813 no 843 0.244314435535758 1245 4301969 YIL048W NEO1
SGTC_170 4197-0004 226 µM 0.69118226214992 0.246546408676009 no 844 0.244725504698533 1192 218692
SGTC_71 0417-1750 47.813 µM 0.690504496241134 0.246759732910995 no 845 0.24493849169844 1187 6811472
SGTC_2146 5545642 200 µM 0.690065950523797 0.246897816144929 no 846 0.245076357213664 1229 825326
SGTC_1167 k781-0610 148 µM 0.688158193189237 0.247498985441443 no 847 0.245676583857818 1226 4525169
SGTC_783 0848-0141 92.7 µM 0.686416721687321 0.248048437124838 no 848 0.246225181401529 1203 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1222 0366-0074 1.18 µM 0.685024387926225 0.248488200064872 no 849 0.246664265809298 1239 286520
SGTC_854 0422-0053 192 µM 0.683192066154073 0.249067563947194 no 850 0.247242742659475 1224 3596728
SGTC_3275 9138069 49.47 µM 0.681457663496199 0.249616628039115 no 851 0.247790973331603 1226 17617007
SGTC_10 0279-0212 42.575 µM 0.68087588534624 0.249800946874719 no 852 0.247975013963982 1240 39851 YBR002C RER2
SGTC_371 0195-0006 7.36 µM 0.680518202038792 0.249914303887601 no 853 0.24808820027263 1123 3928593
SGTC_2240 6690706 185.951 µM 0.679979533880826 0.250085070135066 no 854 0.248258709926836 1160 805876
SGTC_2115 tiliquinol 12.7705 µM 0.679756309906 0.250155853770082 no 855 0.248329387400881 1201 71208 A bioactive hydroxyquinoline.
SGTC_2692 st077426 47.7 µM 0.67862172516199 0.250515791301928 no 856 0.24868878689824 1205 25238571
SGTC_3115 9123671 49.47 µM 0.678113265040087 0.250677185028831 no 857 0.24884994034897 1297 3286988
SGTC_2814 7977482 42.97 µM 0.677116959002372 0.250993588792017 no 858 0.249165874813571 1262 6456762
SGTC_1680 diphenhydramine 100 µM 0.676752147266752 0.251109497399865 no 859 0.249281612082224 1233 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2822 7994718 71.43 µM 0.676248016404258 0.251269717306375 no 860 0.249441595658687 1185 1018011
SGTC_582 0987-0078 156 µM 0.675601262737805 0.251475343881396 no 861 0.249646919796038 1279 1625765
SGTC_96 0929-0093 37.281 µM 0.674490759476595 0.251828620684785 no 862 0.249999679274407 1199 6991579
SGTC_2976 9009005 19.48 µM 0.674490759476595 0.251828620684785 no 863 0.249999679274407 1253 2993148
SGTC_2998 9066762 71.4286 µM 0.672165710666548 0.252569120228993 no 864 0.250739103787746 1278 4945196
SGTC_1925 st057770 10.1 µM 0.670525988794805 0.253092040483614 no 865 0.251261272477601 1176 5989122
SGTC_1041 0206-0046 107 µM 0.669987773828087 0.253263805552365 no 866 0.251432792046321 1242 50494
SGTC_2865 9030313 51.95 µM 0.66839478011687 0.253772549980759 no 867 0.251940813301681 1189 42562754
SGTC_1248 0469-0687 58.6 µM 0.665365369182412 0.254741512369905 no 868 0.252908414682719 1245 4017482
SGTC_927 2425-1185 123 µM 0.664636654113975 0.254974881850758 no 869 0.253141459570094 1230 730375
SGTC_1354 1498-1681 81 µM 0.664112269790681 0.255142884021329 no 870 0.253309228833695 1285 5754243
SGTC_1919 st067113 52.3 µM 0.661941127506924 0.255839089834583 no 871 0.254004476308644 1247 1268243
SGTC_2747 doxorubicin 7.63 µM 0.6612224031545 0.256069776665948 no 872 0.254234848021328 1151 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2114 5491910 81.25 µM 0.659895329699157 0.256496008450113 no 873 0.254660500742235 1293 2849228
SGTC_438 sphingosine 6.67 µM 0.659829375078215 0.256517201507971 no 874 0.254681665115226 1135 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3337 9144342 33.5465 µM 0.656112023529575 0.257713163108777 no 875 0.255876024408271 1266 17682949
SGTC_3073 9114972 49.47 µM 0.655960399373894 0.257762005623091 no 876 0.255924802170143 1196 41905075
SGTC_1774 st048371 48.465 µM 0.65499042006294 0.258074577587945 no 877 0.25623696101626 1227 4242727
SGTC_2882 9058044 58.44 µM 0.654872039143257 0.258112738821423 no 878 0.25627507196338 1217 18076804
SGTC_2244 6635614 200 µM 0.654742668379233 0.258154446083225 no 879 0.256316724303516 1190 836499
SGTC_680 0417-1641 114 µM 0.652844597737389 0.258766758034622 no 880 0.256928234433697 1245 2835990
SGTC_2334 9017922 200 µM 0.652599710692587 0.25884581257652 no 881 0.257007186066555 1277 3163164
SGTC_1600 coumarin 106 71.1 µM 0.651729637571731 0.259126791000069 no 882 0.257287799859783 1316 100336 A hepatotoxic, DNA x-linker.
SGTC_177 1327-0068 8.361 µM 0.651504920505289 0.259199385971301 no 883 0.257360300910532 1274 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_397 arbidol 50 µM 0.650288570757183 0.259592510792507 no 884 0.257752919169077 1321 131410 A RNA synthesis inhibitor.
SGTC_2075 5212009 200 µM 0.649584226926008 0.259820295716761 no 885 0.25798041215961 1219 780898
SGTC_2085 5307070 144.047 µM 0.648627901210652 0.260129736612552 no 886 0.258289458323983 1226 2840351
SGTC_1328 1441-0025 69.2 µM 0.648586624084163 0.260143097039494 no 887 0.258302801756061 1212 4562601
SGTC_2907 7721985 69.9 µM 0.646635722169571 0.260774960907404 no 888 0.258933866412475 1231 3267881
SGTC_1350 1495-0454 146 µM 0.646557493643583 0.260800314249846 no 889 0.258959187872118 1301 1069057
SGTC_2580 diallyl disulphide 81.36 µM 0.645586957302459 0.261114964020082 no 890 0.259273443146496 1288 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_625 k213-0058 121 µM 0.645216104975783 0.261235246569277 no 891 0.259393575470744 1337 3655420
SGTC_2260 7964312 200 µM 0.643360312831175 0.261837583120892 no 892 0.259995164568759 1313 231951
SGTC_2007 4011539 71.82 µM 0.643282081928168 0.261862990251508 no 893 0.260020540347692 1305 45595301
SGTC_2582 agaric acid 100 µM 0.64205421575991 0.262261931200952 no 894 0.260418990887422 1200 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2829 7992743 58.44 µM 0.640017540819791 0.262924344706873 no 895 0.261080597866271 1277 16462845
SGTC_459 nigericin 15.3 µM 0.637947290998438 0.26359855375183 no 896 0.261753995951194 1334 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_35 0133-0054 64.071 µM 0.637520662616167 0.263737601458412 no 897 0.261892877650257 1234 99677
SGTC_2806 7952793 58.44 µM 0.635939398456784 0.264253296792067 no 898 0.262407961007321 1313 2972490
SGTC_368 fentichlor 4.58 µM 0.635308572387363 0.264459170353055 no 899 0.262613591886586 1264 7329 A pesticide.
SGTC_2525 harmine 47.85 µM 0.634812752770781 0.264621041086609 no 900 0.262775272460445 1259 5280953 A monoamine oxidase inhibitor
SGTC_1854 st056233 32.9 µM 0.634154972277031 0.264835865105408 no 901 0.262989844997581 1252 5393174
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.634052851326893 0.264869224655332 no 902 0.263023165586025 1309 368090
SGTC_3351 9150312 21.596 µM 0.631407767869401 0.265734029747008 no 903 0.263886969132655 1289 4904905
SGTC_485 niflumic acid 177 µM 0.629812239975617 0.266256375897334 no 904 0.264408718243998 1314 4488 A COX2 inhibitor.
SGTC_3080 9117754 49.47 µM 0.629744628298428 0.266278522175493 no 905 0.264430839340283 1400 9550191
SGTC_1130 3454-2858 15.9 µM 0.62972961533851 0.26628343981328 no 906 0.264435751387818 1287 715628 YIL048W NEO1
SGTC_2393 9031399 185.94 µM 0.62839423065095 0.266721041569168 no 907 0.264872857792843 1341 1526623 YDL150W RPC53
SGTC_2934 9036370 36.88 µM 0.626644864584307 0.267294853313971 no 908 0.265446026299737 1312 6462800
SGTC_3096 9117468 49.47 µM 0.626253818815109 0.267423205852684 no 909 0.265574235932982 1212 41316311
SGTC_72 0744-0168 198.391 µM 0.621771132537495 0.26889677039928 no 910 0.267046185345057 1292 677577
SGTC_2061 5245884 80.95 µM 0.621455268733759 0.269000755824372 no 911 0.267150058563129 1301 573863
SGTC_982 1491-0518 27.5 µM 0.620460702801082 0.269328308350135 no 912 0.267477259158669 1282 3091256
SGTC_821 1114-0266 29.2 µM 0.61808816081464 0.270110493291993 no 913 0.268258613023122 1304 3123235
SGTC_600 1495-0418 41.6 µM 0.617028955692323 0.270460060941067 no 914 0.268607813494079 1315 5377768
SGTC_2168 5727979 200 µM 0.61656998590479 0.270611604123327 no 915 0.268759198311281 1247 695210
SGTC_870 0573-2213 57.6 µM 0.614161837292903 0.271407423834547 no 916 0.269554194431574 1310 3916321
SGTC_1280 0880-0253 10.1 µM 0.612439661965025 0.271977264529383 no 917 0.270123453696896 1318 6836607
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.611754798262234 0.272204040397201 no 918 0.270350000098935 1384 688801
SGTC_1470 k295-0292 231 µM 0.611683566647054 0.272227632399078 no 919 0.270373568291749 1370 5045612
SGTC_2191 5911152 200 µM 0.611151565030448 0.27240386414253 no 920 0.270549622556078 1319 2875902
SGTC_3278 9139605 49.47 µM 0.610195832783533 0.272720603875276 no 921 0.270866044964681 1357 7958859
SGTC_257 daunorubicin 18.5 µM 0.609985798725377 0.272790235859686 no 922 0.270935607474012 1405 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_616 4092-0450 108 µM 0.609792278684282 0.272854400805716 no 923 0.270999708490696 1361 787165
SGTC_376 3970-0862 59.1 µM 0.605304591934516 0.274344467858923 no 924 0.27248831544891 1332 3135186
SGTC_2300 7976697 71.57 µM 0.605081905993007 0.274418511770203 no 925 0.272562288028317 1275 2236109
SGTC_525 k781-2675 26.7 µM 0.602698921113811 0.275211480140564 no 926 0.273354499711208 1373 3651118 YDL195W SEC31
SGTC_1802 st050112 57.9 µM 0.601448213636737 0.275628119818263 no 927 0.273770747107794 1310 4662563
SGTC_1750 st081859 2.357 µM 0.601078425390312 0.275751364235846 no 928 0.273893876184384 1339 5291695
SGTC_3212 9128307 49.47 µM 0.600780422360435 0.275850703510385 no 929 0.273993122721856 1288 27243542
SGTC_526 4469-0568 170 µM 0.599572165514249 0.276253655862475 no 930 0.274395701022171 1324 2901964
SGTC_739 1486-1183 203 µM 0.598361180895304 0.276657807516878 no 931 0.274799480924045 1347 4346692
SGTC_297 0986-0032 24 µM 0.598269228718651 0.276688507289749 no 932 0.274830152597727 1304 2847425
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.596716067363285 0.277207308276707 no 933 0.275348481707118 1325 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2697 mebhydrolin 72.4 µM 0.594779892891602 0.277854712408871 no 934 0.275995304859004 1402 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3195 9113082 49.47 µM 0.594408608252668 0.277978944194213 no 935 0.276119426156237 1325 17018038
SGTC_1652 st011932 78 µM 0.594173393219917 0.278057661132033 no 936 0.27619807325157 1350 1551076
SGTC_796 1234-0020 70.7 µM 0.593815886628161 0.278177324919551 no 937 0.27631763111269 1302 46495034
SGTC_2868 9035608 32.47 µM 0.59272884802072 0.2785413301926 no 938 0.27668131599614 1332 6462614
SGTC_2718 lomofungin 53.02 µM 0.591040322080235 0.279107208939558 no 939 0.277246702124837 1407 5351222 A RNA synthesis inhibitor.
SGTC_3341 9147222 25.867 µM 0.590425591611582 0.279313363373704 no 940 0.277452678741867 1345 1939759
SGTC_1373 2887-0003 58.5 µM 0.588847068374665 0.279843071542181 no 941 0.277981934043393 1352 776948
SGTC_2819 7996655 46.38 µM 0.588282743379243 0.280032561365986 no 942 0.278171263272481 1304 6456960
SGTC_3170 9103054 49.47 µM 0.588102110961088 0.280093227505891 no 943 0.278231878153701 1298 16432970
SGTC_666 0272-0154 136 µM 0.587983665617029 0.280133011318892 no 944 0.278271628393341 1362 6870312
SGTC_1290 0986-0249 10.2 µM 0.587554294317181 0.280277252919118 no 945 0.278415748542418 1314 53329
SGTC_2649 anisomycin 9.56 µM 0.5872064111502 0.28039414603528 no 946 0.27853254354933 1318 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1035 k081-0041 55.2 µM 0.586898849288222 0.280497510341593 no 947 0.278635821335705 1359 731709
SGTC_393 acivicin 6.25 µM 0.58687265809435 0.280506313437779 no 948 0.278644617073524 1319 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2112 5488546 200 µM 0.585458746982891 0.280981740046786 no 949 0.279119648649706 1336 600757
SGTC_652 0437-0092 114 µM 0.584391122339025 0.281340985909362 no 950 0.279478599096106 1328 3091274
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.583463088208399 0.281653440854676 no 951 0.279790799256492 1353 756377
SGTC_1867 st057372 64 µM 0.583321497648232 0.281701126945681 no 952 0.279838446638958 1362 688837
SGTC_615 k087-0205 167 µM 0.582716882953259 0.28190479808774 no 953 0.280041952978297 1303 9642773
SGTC_1441 4106-0040 13 µM 0.581414284620979 0.282343833649942 no 954 0.280480636178941 1350 2904180
SGTC_740 k014-0057 261 µM 0.581150140194332 0.282432902572509 no 955 0.28056963409762 1429 4012779
SGTC_2368 9071271 200 µM 0.580856711353419 0.282531861976729 no 956 0.280668514803642 1323 27209959
SGTC_3055 9094636 49.47 µM 0.58069429572683 0.282586644105361 no 957 0.280723253452437 1407 25236176
SGTC_289 k017-0060 526 µM 0.579833611323837 0.282877034638393 no 958 0.281013414529992 1358 5512909
SGTC_2170 morpholine 200 µM 0.57939494914788 0.283025092134632 no 959 0.281161355699369 1440 121171 Reacts with secondary amines.
SGTC_3256 9138902 49.47 µM 0.578707522194224 0.283257187646962 no 960 0.281393269756958 1407 17228773
SGTC_3286 9117135 37.221 µM 0.57815708138976 0.283443098405927 no 961 0.281579035960788 1331 3438150
SGTC_2125 5246583 200 µM 0.577860358230514 0.283543340574285 no 962 0.281679200477832 1422 835267
SGTC_1159 4092-0538 61.2 µM 0.577323309419757 0.283724815292281 no 963 0.281860535139072 1411 717301
SGTC_604 1000-0114 314 µM 0.576054589328065 0.284153750585407 no 964 0.282289142055142 1445 1572745
SGTC_797 k781-0471 270 µM 0.575523229088828 0.284333487626737 no 965 0.282468742607761 1417 23738129
SGTC_58 0957-0393 9 µM 0.575490278200218 0.284344635329131 no 966 0.282479881866414 1324 6997992
SGTC_2731 amoxapine 43.43 µM 0.575168991031832 0.284453341787911 no 967 0.282588506118519 1419 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2013 4024628 200 µM 0.571359662490456 0.28574372641496 no 968 0.283877933209814 1399 5230760
SGTC_328 k915-0120 63.5 µM 0.571142934868913 0.285817225086893 no 969 0.283951378355266 1430 6624543
SGTC_2215 7188065 200 µM 0.570111561232667 0.286167117173862 no 970 0.284301017122871 1411 940217
SGTC_2012 4023501 200 µM 0.569054502852218 0.28652593375542 no 971 0.28465957648702 1348 3477460
SGTC_1457 k015-0032 57.3 µM 0.56803107677488 0.286873537147702 no 972 0.285006933171948 1381 4302660
SGTC_2618 avocadyne 43.43 µM 0.564220004465787 0.288169710124995 no 973 0.286302207601225 1368 3015189
SGTC_791 1348-1292 225 µM 0.562741117833829 0.288673433105015 no 974 0.286805590465003 1394 5437054
SGTC_677 0929-0063 136 µM 0.562119893697494 0.288885151622391 no 975 0.287017167542305 1369 1539583
SGTC_254 nsc-64875 3.808 µM 0.561460713312192 0.289109885835025 no 976 0.287241752598455 1515 56993
SGTC_2674 ligustilide 100 µM 0.56112346290629 0.289224896319073 no 977 0.287356687139513 1369 5319022 A signalling regulator.
SGTC_223 busulfan 5 mM 0.560639797501995 0.289389875361823 no 978 0.287521557704722 1413 2478 A DNA alkylator.
SGTC_1564 D-Arginine 115 µM 0.560331706196988 0.289494988844721 no 979 0.287626602355885 1314 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_717 1532-0246 73.2 µM 0.560050502129466 0.289590944685749 no 980 0.287722495554012 1365 9561992
SGTC_2037 5169046 200 µM 0.558894442917402 0.289985585939282 no 981 0.288116881100102 1420 5718022
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.558685333482834 0.290056996062664 no 982 0.288188245284275 1384 4330530
SGTC_2431 5490079 200 µM 0.557023448588191 0.290624816656385 no 983 0.288755704194937 1397 5722345
SGTC_537 1334-0398 209 µM 0.554922647666926 0.291343346094001 no 984 0.289473785116414 1444 5846986
SGTC_1836 st055642 81 µM 0.553935083548174 0.291681405327805 no 985 0.289811636863167 1333 8571
SGTC_2634 4'-methoxyflavone 100 µM 0.553654546551395 0.291777471032743 no 986 0.289907644018943 1430 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1080 nisoldipine 24.4 µM 0.552469404333433 0.292183467886578 no 987 0.290313395441896 1386 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1018 4259-0013 28.1 µM 0.552412367129157 0.2922030138787 no 988 0.290332929700237 1430 6801262
SGTC_217 ketoconazole 989 nM 0.549914672777838 0.293059540896615 no 989 0.291188949921471 1355 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1383 3049-0032 20.7 µM 0.54941638705788 0.293230555808898 no 990 0.291359865374849 1485 712864
SGTC_2602 kawain 100 µM 0.547621306113286 0.293847022516566 no 991 0.291975978323414 1384 5369129
SGTC_1283 0922-0125 16.4 µM 0.546108085791447 0.294367157879865 no 992 0.292495821001916 1481 3360884
SGTC_1012 4112-3522 18 µM 0.543843003245804 0.295146522328441 no 993 0.293274756799245 1438 3112398
SGTC_1591 genipin 88.4 µM 0.543818552625054 0.295154940423561 no 994 0.293283170329153 1452 442424 A DNA cross-linking agent.
SGTC_366 0181-0206 4.31 µM 0.542020033781653 0.295774454712011 no 995 0.293902352440953 1528 274874
SGTC_2732 terfenadine 20 µM 0.541478598035548 0.295961073538676 no 996 0.294088872669608 1422 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1296 1068-0102 11.9 µM 0.540781317356247 0.296201487670674 no 997 0.294329160779891 1451 767053
SGTC_3030 9087619 49.47 µM 0.539525050395662 0.2966348596075 no 998 0.294762308386112 1390 25236973
SGTC_21 0849-0113 22.993 µM 0.537343026715484 0.297388277463446 no 999 0.295515344915052 1392 1560156
SGTC_1504 k297-0033 30 µM 0.536840203219953 0.29756201821218 no 1000 0.295688999288253 1343 4388117
SGTC_998 3996-0085 177 µM 0.535872573518423 0.297896493896756 no 1001 0.296023310331118 1523 715391
SGTC_3116 9124943 49.47 µM 0.534137889143271 0.298496542207339 no 1002 0.296623068689472 1346 41905195 YPL160W CDC60
SGTC_628 1636-0253 16 µM 0.533777596014964 0.298621240892938 no 1003 0.296747707990344 1486 4456143
SGTC_576 1073-0113 22.7 µM 0.53335320526019 0.298768154364807 no 1004 0.296894551882639 1537 5439563
SGTC_859 0439-0102 54.6 µM 0.532173660898633 0.299176655571709 no 1005 0.297302861803533 1463 610143
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.531753362378062 0.299322275083398 no 1006 0.29744841390304 1425 3256 An antibiotic and ribosome inhibitor.
SGTC_1937 st074714 47.2 µM 0.530408563320119 0.299788419252192 no 1007 0.297914345017299 1390 17250970
SGTC_2566 crystal violet carbinol 226 nM 0.530000578834768 0.299929902807469 no 1008 0.298055764731577 1349 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3220 9131269 49.47 µM 0.529424218398635 0.300129828371783 no 1009 0.298255600738814 1456 17722206
SGTC_2916 7875993 68.79 µM 0.527413236802735 0.300827861007039 no 1010 0.298953326691347 1543 1299250
SGTC_1655 st012546 55.1 µM 0.524141096425753 0.301965217334025 no 1011 0.300090203259741 1421 720985 YLR208W SEC13
SGTC_3022 9087993 49.47 µM 0.52413899968091 0.301965946756049 no 1012 0.300090932381994 1503 17173644
SGTC_2050 5263056 171 µM 0.522172454200266 0.302650422799952 no 1013 0.300775131587787 1472 763468 YGL055W OLE1
SGTC_1502 4534-4282 27.7 µM 0.521398106859491 0.302920132853848 no 1014 0.301044735001943 1448 3278949
SGTC_3024 9090631 49.47 µM 0.521127809216496 0.303014304550145 no 1015 0.301138869789196 1444 25236383
SGTC_148 3253-0744 288.01 µM 0.521051846219125 0.303040772415604 no 1016 0.301165327311298 1403 6893655
SGTC_2647 atorvastatin 60.16 µM 0.520341019764774 0.303288496519362 no 1017 0.301412955251137 1493 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.519836509201388 0.303464374123983 no 1018 0.301588765287887 1462 77254
SGTC_2898 9056270 58.44 µM 0.518612042345038 0.30389142529535 no 1019 0.302015654834114 1441 19154699
SGTC_1251 0490-5699 265 µM 0.515652120110457 0.304924847822583 no 1020 0.303048700504473 1532 3883818
SGTC_757 1066-0008 322 µM 0.51449337947398 0.305329833483969 no 1021 0.303453543972234 1527 6842497
SGTC_760 0568-0725 82.9 µM 0.513732114035512 0.305596029367561 no 1022 0.303719648073424 1542 3916171
SGTC_2136 5328288 199.296 µM 0.513352288389734 0.305728883541012 no 1023 0.303852456938072 1432 262395
SGTC_1082 camptothecin 424.86 nM 0.509776914413725 0.306980717679408 no 1024 0.305103880411567 1346 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1732 st034308 51.822 µM 0.508923723086228 0.30727977640792 no 1025 0.305402845376562 1438 830119
SGTC_3215 9129942 49.47 µM 0.508591235624672 0.307396353899916 no 1026 0.305519386770977 1471 17682944
SGTC_186 3455-3465 67.277 µM 0.507556878701136 0.307759146821639 no 1027 0.305882068979648 1451 755278
SGTC_2521 angolensin 13.4 µM 0.50731075886374 0.307845499213956 no 1028 0.305968395381804 1502 821428 A flavenoid.
SGTC_207 4185-0010 4.486 µM 0.503702925082952 0.309112545493336 no 1029 0.307235076276816 1522 3761753
SGTC_790 1575-0012 79.1 µM 0.503640464208845 0.309134501388023 no 1030 0.307257026103096 1515 378741 YLR208W SEC13
SGTC_1097 itavastatin 7.23 µM 0.503576582023765 0.309156957599125 no 1031 0.307279476116767 1478 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2448 5185112 27.17 µM 0.503354308265882 0.309235098028648 no 1032 0.307357595054171 1454 5718189
SGTC_1816 st051957 91.6 µM 0.502705169784857 0.30946335231614 no 1033 0.307585787210393 1483 674121
SGTC_1065 prochlorperazine maleate 2.48 µM 0.502409934930062 0.309567189043199 no 1034 0.30768959599268 1492 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2947 9072639 7.68 µM 0.500513140994644 0.310234670671542 no 1035 0.308356902755881 1426 16488146
SGTC_1662 st014054 52 µM 0.49962528673369 0.310547321618744 no 1036 0.308669474630593 1460 2838777
SGTC_991 3996-0057 64.7 µM 0.499467842871247 0.310602778543345 no 1037 0.308724917718229 1501 715343
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.499328703024247 0.310651791772475 no 1038 0.308773918765441 1457 229346 A bile salt which induces apoptosis.
SGTC_1915 st067105 30.6 µM 0.499056444472551 0.310747706952541 no 1039 0.308869810234773 1429 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2827 7993847 71.43 µM 0.498895452129088 0.310804429715968 no 1040 0.308926519055965 1506 2985692
SGTC_1871 st057448 67.3 µM 0.498515295108692 0.310938389064205 no 1041 0.309060445713244 1571 691747
SGTC_3317 9138495 8.753 µM 0.498159738781184 0.311063702323759 no 1042 0.309185728691531 1469 17020139
SGTC_140 0062-0056 502.533 µM 0.494893222437639 0.312215986072425 no 1043 0.310337747555957 1390 3758964
SGTC_2780 5215298 71.43 µM 0.494767657183527 0.312260316768822 no 1044 0.310382068549547 1543 2834131
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.493817733677634 0.312595774404193 no 1045 0.310717453931744 1546 688751
SGTC_2373 9071805 200 µM 0.493459549846142 0.31272230440359 no 1046 0.310843957214545 1604 10149009
SGTC_2148 5546263 113.568 µM 0.492050240571715 0.313220363204006 no 1047 0.311341913701596 1506 792097
SGTC_2526 patulin 37.61 µM 0.491175788520744 0.313529571541458 no 1048 0.311651060805285 1540 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1797 st048695 56.8 µM 0.490946385525488 0.313610710702177 no 1049 0.311732184187347 1562 592262 YIL048W NEO1
SGTC_3012 9080433 71.4286 µM 0.49075266283515 0.313679236868187 no 1050 0.31180069712122 1572 17688859
SGTC_1309 pyrazolanthrone 13.4 µM 0.490732205019932 0.313686473853978 no 1051 0.311807932714589 1590 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2414 st077232 92.9 µM 0.490388073268326 0.313808221772366 no 1052 0.311929657351705 1442 729801
SGTC_2736 butenafine 14.65 µM 0.490147263673078 0.313893428141344 no 1053 0.312014847588155 1539 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1269 0831-0796 3.05 µM 0.490139546254838 0.313896158982345 no 1054 0.312017577914306 1571 927758
SGTC_2450 5739737 12.93 µM 0.489415292146554 0.314152484703314 no 1055 0.312273855915927 1488 2262825
SGTC_3252 9135871 49.47 µM 0.488249528805642 0.314565256264915 no 1056 0.312686553152439 1519 17682838
SGTC_1171 0368-0077 21.4 µM 0.487135149517269 0.314960050646464 no 1057 0.31308127935061 1469 3239779
SGTC_92 0063-0024 660.874 µM 0.4871013037506 0.314972044596166 no 1058 0.313093271273294 1504 3594437
SGTC_1444 4112-3581 28 µM 0.487075811687497 0.3149810783665 no 1059 0.313102303518618 1506 2877249
SGTC_1697 st025554 27.742 µM 0.486832293081892 0.315067381046147 no 1060 0.313188591704173 1485 1269519
SGTC_3279 9140807 49.47 µM 0.486470111453174 0.315195756421917 no 1061 0.313316945770591 1498 45595718
SGTC_1521 st012942 49.4 µM 0.486118333171718 0.315320465696816 no 1062 0.313441634631607 1679 24207259
SGTC_1485 3909-9022 254 µM 0.486097594127602 0.315327818573397 no 1063 0.313448986313407 1499 714516
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.484726353867 0.315814143971993 no 1064 0.313935234868626 1547 279621
SGTC_1965 Pectolinarigenin 58.4 µM 0.483396576559369 0.316286068821148 no 1065 0.31440708925222 1477 5320438 An anti-inflammatory.
SGTC_1051 3253-3903 78 µM 0.478919730311388 0.31787705448849 no 1066 0.315997867048633 1475 5509239
SGTC_901 1112-0062 60.1 µM 0.478076304260887 0.318177169897721 no 1067 0.31629794836605 1520 1908457
SGTC_1085 doxorubicin 7.67 µM 0.474794679111566 0.319346001826109 no 1068 0.317466662955205 1618 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1265 0819-1001 68.8 µM 0.473917467689702 0.319658747319249 no 1069 0.317779381208843 1473 3106768
SGTC_2948 9070189 9.45 µM 0.471804020667189 0.3204127649786 no 1070 0.318533340392953 1596 6473636 YDL196W YDL196W
SGTC_855 0428-0020 25 µM 0.469495271077472 0.32123730902319 no 1071 0.31935783211594 1514 6812414
SGTC_408 cantharidin 100 µM 0.469004954949642 0.321412533611545 no 1072 0.319533047146663 1535 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1512 0259-0544 12.2 µM 0.468929903933425 0.321439358150145 no 1073 0.319559870270364 1593 18476
SGTC_356 1634-0012 32.5 µM 0.465123399886871 0.322801087742683 no 1074 0.32092154483899 1590 735457
SGTC_2730 imipramine 71.33 µM 0.464322868378371 0.323087771388922 no 1075 0.321208221092601 1558 3696 A tricyclic antidepressant.
SGTC_2411 st077133 39.94 µM 0.46243238329486 0.32376520254218 no 1076 0.321885640554903 1677 1403142 YNL221C POP1
SGTC_381 3461-2219 42.7 µM 0.461871200736016 0.323966407701708 no 1077 0.322086843803955 1615 2883159
SGTC_1995 st072814 61.1 µM 0.461552098632622 0.324080840813329 no 1078 0.32220127614777 1485 5769371
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.460905216455322 0.324312870040179 no 1079 0.322433304526787 1623 94937 An inhibitor of serotonin biosynthesis.
SGTC_1996 st072960 66.8 µM 0.460786214770942 0.324355562014993 no 1080 0.322475996449 1554 1719405
SGTC_1863 st057641 20.1 µM 0.459106727960089 0.324958325626651 no 1081 0.323078762744452 1542 3921635
SGTC_1588 farnesol 29.9 µM 0.457993413608585 0.325358144176167 no 1082 0.323478586600368 1511 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3041 9091929 49.47 µM 0.45548782666899 0.326258697041436 no 1083 0.324379161697474 1581 25236887
SGTC_3189 9110682 49.47 µM 0.454678294708309 0.326549874316553 no 1084 0.324670349201505 1549 17122418
SGTC_226 1,3-diallylurea 8.28947 mM 0.453395390813302 0.327011533272148 no 1085 0.32513202741481 1561 74537 YKL182W FAS1
SGTC_810 3825-7150 143 µM 0.453066599844594 0.327129892903132 no 1086 0.325250392582934 1710 22330411 YGL099W LSG1
SGTC_713 1488-1073 324 µM 0.452705909129692 0.327259755946172 no 1087 0.325380261982716 1564 3312542
SGTC_1362 1611-0397 101 µM 0.45107751299692 0.327846303628204 no 1088 0.325966842041486 1541 27816
SGTC_1384 3089-0840 101 µM 0.450848537020416 0.327928814800347 no 1089 0.326049358249271 1650 1069836
SGTC_303 1348-1668 34.2 µM 0.450645571417538 0.328001960193644 no 1090 0.326122508205765 1573 5380509
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.44987691827967 0.328279029653721 no 1091 0.32639959579547 1515 390807
SGTC_712 r015-0009 80.6 µM 0.449803101812617 0.328305642584402 no 1092 0.326426210537843 1612 6813872 YLR060W FRS1
SGTC_1226 3909-7979 35.4 µM 0.447685440743828 0.329069490078649 no 1093 0.327190115278389 1648 6615510
SGTC_153 4077-0274 519.67 µM 0.44757568509441 0.329109098807323 no 1094 0.32722972725182 1678 3121976
SGTC_1546 5-methoxyflavanone 78.7 µM 0.447014957210621 0.32931148477817 no 1095 0.327432130226909 1630 147795
SGTC_145 3737-0113 38.366 µM 0.444852120564633 0.330092595037601 no 1096 0.328213312769022 1678 6849351
SGTC_3153 9100258 49.47 µM 0.44432104849609 0.330284505634999 no 1097 0.328405242740983 1514 25236848
SGTC_327 1273-0057 3.96 µM 0.443939376952946 0.330422455764861 no 1098 0.328543207190949 1540 3108138
SGTC_926 2268-1401 59.4 µM 0.442753246068645 0.330851314116187 no 1099 0.328972112159114 1538 2931578
SGTC_900 1112-0045 141 µM 0.442079466696197 0.331095025228395 no 1100 0.329215851176535 1498 56211 YIL048W NEO1
SGTC_3233 9132340 49.47 µM 0.441196980033123 0.33141433560953 no 1101 0.329535199668097 1512 17682950
SGTC_1724 st037281 8.293 µM 0.440544506886157 0.33165049897783 no 1102 0.32977139235234 1538 574124 YDL195W SEC31
SGTC_850 0388-0143 75.9 µM 0.438871976032046 0.332256178848532 no 1103 0.330377151792425 1547 67273
SGTC_3104 9120930 49.47 µM 0.438487997563828 0.332395292344266 no 1104 0.330516284453623 1573 17014836
SGTC_2654 protoveratrine a 100 µM 0.438455712218557 0.332406990217501 no 1105 0.330527983953595 1572 5702278 A heart drug and vasodilator.
SGTC_2033 5192550 145 µM 0.43833178604835 0.332451893611174 no 1106 0.33057289361346 1537 182073
SGTC_3197 9113331 49.47 µM 0.438288616501542 0.332467536224353 no 1107 0.330588538417664 1676 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1822 st052468 42 µM 0.437978586850035 0.332579884957712 no 1108 0.330700903010787 1536 2873678
SGTC_1483 3453-0561 55.9 µM 0.437560182182692 0.332731530538524 no 1109 0.330852570341984 1608 4546991
SGTC_1357 1503-1303 39.5 µM 0.432165894898725 0.334689066615293 no 1110 0.332810422502122 1569 292895
SGTC_1120 ficusin 1.78878 µM 0.430511316811495 0.33529040206113 no 1111 0.333411868168199 1683 6199 A DNA cross-linker.
SGTC_2296 7971656 126.45 µM 0.426323756338139 0.336814201887338 no 1112 0.334935974788845 1562 666570
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.425336304360151 0.337173914866147 no 1113 0.335295765927207 1544 23665772 A membrane-active detergent.
SGTC_1692 fluoroquinolonic acid 71 µM 0.424263745906391 0.337564799495444 no 1114 0.335686737967213 1626 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1786 berberine 21.6 µM 0.42137021660357 0.338620194662835 no 1115 0.336742382011924 1540 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1609 st001574 46.4 µM 0.418429262077413 0.33969418799626 no 1116 0.337816647833754 1573 3960012
SGTC_182 3448-4371 550.524 µM 0.418357389576706 0.339720451119484 no 1117 0.33784291786268 1753 3491403
SGTC_2737 bleomycin 30.5 nM 0.417910505124292 0.339883765822164 no 1118 0.338006275767117 1607 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3113 9123498 49.47 µM 0.41711303290018 0.340175278095658 no 1119 0.338297866264466 1629 8897275
SGTC_1610 st001799 48.1 µM 0.417068485581463 0.340191564981029 no 1120 0.338314157562172 1535 621897
SGTC_603 3794-0023 45.9 µM 0.416999331637668 0.340216848852237 no 1121 0.338339448291911 1702 3802260
SGTC_1783 st039459 87.517 µM 0.416976018916598 0.340225372545933 no 1122 0.338347974300164 1744 729761
SGTC_1690 st023502 41.2 µM 0.416450949558395 0.340417372200885 no 1123 0.338540026413353 1683 24207482
SGTC_1798 st045719 60.953 µM 0.41590431797135 0.34061730036993 no 1124 0.338740009861755 1612 3980186
SGTC_981 1488-1094 54.9 µM 0.414664920885342 0.341070770391787 no 1125 0.339193607740383 1569 3449522
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.414115211860817 0.341271971231665 no 1126 0.33939486640809 1744 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1674 st016616 23.6 µM 0.413834136980655 0.341374865830664 no 1127 0.339497790841197 1542 625830
SGTC_2847 9005661 71.43 µM 0.413696598831931 0.341425219460942 no 1128 0.33954815913572 1589 2991449
SGTC_3287 9117173 37.0625 µM 0.412717958834427 0.341783587525222 no 1129 0.33990663278558 1603 2789709
SGTC_1189 1431-2119 7.28 µM 0.412084764162681 0.3420155330247 no 1130 0.340138647762348 1613 3107275
SGTC_1669 st015249 58.4 µM 0.411153540868672 0.342356757690686 no 1131 0.340479976265235 1702 722793
SGTC_1303 1160-0052 261 µM 0.410531068043212 0.342584919881423 no 1132 0.340708208966331 1615 3562476
SGTC_316 k060-0003 58.6 µM 0.408759387760237 0.343234628621809 no 1133 0.341358123221625 1679 6152314
SGTC_1719 st032227 49.2 µM 0.408099198021706 0.343476851388944 no 1134 0.341600424398364 1552 3125804
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.407782471190863 0.34359308088478 no 1135 0.341716691863517 1581 6708561
SGTC_1194 1488-0194 225 µM 0.407267615037172 0.343782049610674 no 1136 0.341905722797896 1614 1391452
SGTC_1372 2752-0194 270 µM 0.406655097077619 0.344006914196232 no 1137 0.342130662178147 1559 823334
SGTC_304 1310-0298 97 µM 0.404604464746725 0.344760133481435 no 1138 0.342884138082679 1605 1550234
SGTC_1431 4049-0260 9.09 µM 0.40432183595371 0.344863994421595 no 1139 0.342988035142047 1652 3854841
SGTC_1789 tunicamycin 25 nM 0.404225689539141 0.344899329145453 no 1140 0.343023382194612 1598 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1617 st002906 78 µM 0.403322935825719 0.345231165682883 no 1141 0.343355335517124 1606 5150859
SGTC_2495 cafestol 54.53 µM 0.402652459375431 0.345477698189306 no 1142 0.343601955960534 1657 16667697 An anti-infammatory.
SGTC_2019 4016004 108 µM 0.401863104839983 0.345768025895698 no 1143 0.343892388506967 1574 45595336
SGTC_2851 9015922 71.43 µM 0.400406397336708 0.346304046742514 no 1144 0.344428606553538 1710 2996893
SGTC_2371 9071574 200 µM 0.399744963137389 0.346547534694591 no 1145 0.344672185640735 1666 45596039
SGTC_3160 9100216 49.47 µM 0.399731939182458 0.346552329725463 no 1146 0.344676982476097 1625 17191039
SGTC_1839 st053978 48 µM 0.399369587568536 0.346685746613088 no 1147 0.344810449722912 1649 3788398
SGTC_483 fpl-64176 144 µM 0.397650010071101 0.347319149423321 no 1148 0.345444095591753 1650 3423
SGTC_557 1315-0110 16.2 µM 0.394532338045153 0.348468624489155 no 1149 0.346594028493128 1573 6833801
SGTC_2689 tacrolimus 100 µM 0.39409692186881 0.348629272041672 no 1150 0.346754741747347 1621 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_708 3448-5400 146 µM 0.394015751912641 0.34865922284065 no 1151 0.346784704842087 1624 3462195
SGTC_1436 4092-1007 8.32 µM 0.392957636917074 0.349049741584897 no 1152 0.347175385242698 1633 2881121
SGTC_1981 st071826 47 µM 0.391047291748403 0.349755197882362 no 1153 0.347881139848609 1610 11838600
SGTC_259 usnic acid 108.925 µM 0.388944984970533 0.350532142069621 no 1154 0.348658421914125 1703 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.388446076003689 0.350716614575356 no 1155 0.348842976079233 1673 66535 A nucleotide analog.
SGTC_636 0kpi-0074 126 µM 0.386757786671797 0.35134112355064 no 1156 0.349467765585417 1647 616434
SGTC_2798 7813637 45.45 µM 0.386649673880978 0.351381128859054 no 1157 0.349507789078968 1704 956368
SGTC_735 3076-0345 636 µM 0.386255914899138 0.351526846621747 no 1158 0.349653573298646 1749 2888990
SGTC_2189 6047310 154.431 µM 0.385478716154517 0.351814527354769 no 1159 0.349941386238588 1633 711535
SGTC_107 0358-0022 2.6945 µM 0.384913884030137 0.352023653673544 no 1160 0.350150609500931 1722 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2461 5755302 26.15 µM 0.382583902444828 0.352886790502856 no 1161 0.351014153897212 1762 2788904
SGTC_986 1493-0483 84 µM 0.381780694227437 0.353184513157662 no 1162 0.351312019911514 1737 40079
SGTC_3333 9141820 12.094 µM 0.377308326385301 0.354843910761602 no 1163 0.352972242566285 1631 1939433
SGTC_778 3456-2434 196 µM 0.376911003219053 0.354991464740882 no 1164 0.353119872040471 1814 5539063
SGTC_343 4130-2827 29.8 µM 0.375534389760228 0.355502866050453 no 1165 0.353631537691867 1628 1118244
SGTC_2685 mycophenolic acid 18.85 µM 0.375356849789086 0.355568839749977 no 1166 0.353697545796507 1724 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2997 9067075 71.4286 µM 0.374331965778092 0.355949770298973 no 1167 0.354078676354878 1722 27209819
SGTC_1049 3226-0134 66 µM 0.373718362891492 0.356177904084846 no 1168 0.354306931028678 1665 5702385
SGTC_350 k064-0020 19.8 µM 0.373690034758469 0.356188437554864 no 1169 0.354317470100357 1778 2790705
SGTC_2344 7990960 76.95 µM 0.372520390629011 0.356623451154538 no 1170 0.354752716578276 1673 140813
SGTC_2427 5545055 42.75 µM 0.372379579279484 0.356675834251309 no 1171 0.354805127920279 1702 5372858
SGTC_3082 9117008 49.47 µM 0.372171098107552 0.356753396098453 no 1172 0.354882731669134 1653 41448529
SGTC_1866 st057638 64 µM 0.372044644139223 0.356800444016221 no 1173 0.354929805050395 1672 688802
SGTC_3131 9127911 49.47 µM 0.37122067747985 0.357107058808432 no 1174 0.35523658664994 1705 45595681
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.370143091506688 0.357508189792701 no 1175 0.35563793811046 1749 140250 A respiratory chain inhibitor.
SGTC_3231 9132313 49.47 µM 0.367563831948076 0.358468957040681 no 1176 0.356599243780291 1696 4905967
SGTC_1459 k035-0031 35.7 µM 0.367227652678565 0.358594249086887 no 1177 0.356724607115768 1568 3877128 YMR208W ERG12
SGTC_1279 0874-0590 65.2 µM 0.366740926847377 0.358775675924302 no 1178 0.35690613762116 1708 3523074
SGTC_2694 st077685 81.9 µM 0.366019799762872 0.359044534300479 no 1179 0.357175150578215 1623 2838096
SGTC_2946 9065502 71.43 µM 0.365498733968019 0.359238847137491 no 1180 0.357369575844821 1647 16489101
SGTC_943 3253-1379 105 µM 0.359939427501796 0.361314249186929 no 1181 0.359446215728409 1765 668464
SGTC_1335 1486-0900 202 µM 0.358699514773169 0.361777693538818 no 1182 0.359909945709635 1674 X1335
SGTC_2856 9022925 19.48 µM 0.358013869747894 0.362034055403671 no 1183 0.360166467016333 1704 4944862
SGTC_1033 k072-0102 21.3 µM 0.357690071542479 0.362155144699392 no 1184 0.360287631979069 1789 5965931
SGTC_1302 1159-0335 255 µM 0.357041675100187 0.362397663939032 no 1185 0.360530303453307 1660 649284
SGTC_529 4076-0302 30.3 µM 0.356517216405217 0.36259386724593 no 1186 0.360726630592193 1671 5816522
SGTC_2975 9084847 53.72 µM 0.35596383699027 0.362800929105548 no 1187 0.360933823787459 1676 27211724
SGTC_1396 3511-0007 98.6 µM 0.354963995188284 0.363175148633718 no 1188 0.361308282369331 1684 X1396
SGTC_1681 tripelennamine 100 µM 0.353960553344693 0.363550846946713 no 1189 0.3616842228712 1634 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_467 ro 31-8220 72.8 µM 0.352426572630839 0.364125437750322 no 1190 0.362259188316525 1805 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_782 0083-0095 30.5 µM 0.351248425597413 0.364566949706622 no 1191 0.362700991623329 1691 3591729 An indicator and reagent.
SGTC_2281 7943571 200 µM 0.350374962542988 0.364894397038902 no 1192 0.363028656985148 1873 1244024
SGTC_1249 0481-0015 10.2 µM 0.349305464844785 0.365295468837195 no 1193 0.363429998094997 1664 4227577
SGTC_1499 4480-0877 67.3 µM 0.349250979477095 0.365315905316441 no 1194 0.363450448363483 1731 2861909
SGTC_556 4058-0063 51.5 µM 0.348796542717497 0.365486371245164 no 1195 0.363621029563105 1710 6615692
SGTC_987 1497-1013 404 µM 0.347670402851076 0.365908917367146 no 1196 0.364043863349076 1728 1676435
SGTC_202 3594-0513 34.79 µM 0.347459292831537 0.365988147429191 no 1197 0.364123147656524 1724 708429
SGTC_2196 6573537 42.6665 µM 0.34698307957127 0.366166892311871 no 1198 0.364302015273468 1798 2903087
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.34589272049739 0.366576263880808 no 1199 0.364711669789425 1774 5377381
SGTC_835 0312-0010 67.2 µM 0.345393949357302 0.366763576434176 no 1200 0.364899112668418 1702 1626196
SGTC_2903 5923464 63.88 µM 0.344779001505984 0.366994562606188 no 1201 0.365130260295519 1775 2876576
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.344543408293458 0.367083068685539 no 1202 0.365218828456285 1864 5024745
SGTC_715 0868-0130 184 µM 0.344121329293304 0.36724165015807 no 1203 0.365377521464639 1859 2876258
SGTC_2144 5628481 200 µM 0.343973924475883 0.36729703771775 no 1204 0.365432948071299 1719 2818399
SGTC_1406 3909-7906 11.9 µM 0.343767886726223 0.367374461308204 no 1205 0.365510426322565 1745 X1406
SGTC_3077 9117319 49.47 µM 0.343041052459046 0.367647629633151 no 1206 0.365783788238314 1732 17154678
SGTC_3167 9103034 49.47 µM 0.340967929019331 0.368427145413313 no 1207 0.366563862739839 1731 5127859
SGTC_1322 1348-1070 12 µM 0.340392473550194 0.368643618815674 no 1208 0.366780492950657 1791 6758089
SGTC_1304 1165-0502 251 µM 0.334291243431665 0.370941316139999 no 1209 0.369079898740101 1761 767425
SGTC_1014 4130-3005 69.3 µM 0.332665972165198 0.371554167238036 no 1210 0.369693219089398 1685 743608
SGTC_339 3091-4833 71.4 µM 0.331979831459111 0.37181299243474 no 1211 0.36995224417469 1765 3240077
SGTC_138 0850-0259 40.9225 µM 0.330520226008393 0.37236377571994 no 1212 0.370503456199936 1744 6813004
SGTC_2201 6605497 169.863 µM 0.328552676161214 0.373106645390171 no 1213 0.371246911395055 1809 670741
SGTC_280 3448-3607 3.04 µM 0.326830174079943 0.373757382248641 no 1214 0.371898167998438 1853 626179
SGTC_2070 5230947 200 µM 0.32640672438439 0.373917410744148 no 1215 0.372058325285873 1838 2835538
SGTC_415 dibenzyl ketone 100 µM 0.325343723670228 0.374319231633369 no 1216 0.372460471260663 1855 7593
SGTC_2801 7907800 81.82 µM 0.32331063768996 0.375088130824146 no 1217 0.373229999274349 1714 6620925
SGTC_3251 9135047 49.47 µM 0.323271341797322 0.375102997163795 no 1218 0.373244877859413 1845 17682963
SGTC_1102 cgs 12066b 26.1 µM 0.321580797654293 0.375742735695656 no 1219 0.373885146480722 1769 6438352 A 5-HT1B full agonist.
SGTC_1833 st055984 71 µM 0.320534458210309 0.376138864543015 no 1220 0.374281606631618 1755 676288
SGTC_1859 st055998 20 µM 0.319842810420493 0.376400783990472 no 1221 0.374543746423934 1889 676301
SGTC_2774 tamoxifen 10.92 µM 0.319538375200597 0.376516088324766 no 1222 0.374659148084975 1743 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2821 7996764 71.43 µM 0.319386258780565 0.376573706295437 no 1223 0.374716814764504 1779 2987135
SGTC_1482 3346-2049 8.48 µM 0.319380329058734 0.376575952384389 no 1224 0.37471906275325 1815 3826804
SGTC_404 fumagillin 50 µM 0.31909390298305 0.376684451224447 no 1225 0.374827653453734 1774 12015870 A methionine aminopeptidase binder.
SGTC_857 0438-0306 1.35 µM 0.318834270830557 0.376782808883656 no 1226 0.374926094539092 1765 4686136
SGTC_2978 9011784 42.97 µM 0.318824991543651 0.376786324347264 no 1227 0.374929612987157 1919 2994934
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.318771008631316 0.376806776009718 no 1228 0.374950082015732 1739 6708784 An antioxidant flavonoid
SGTC_1964 st076914 61 µM 0.318262883846641 0.376999298241206 no 1229 0.37514276802925 1755 24208661
SGTC_751 0833-0568 350 µM 0.317856901482915 0.377153141948298 no 1230 0.375296743010918 1777 6954252
SGTC_510 ag-490 170 µM 0.317845823619437 0.377157340087784 no 1231 0.375300944737612 1846 5328779
SGTC_1905 st060207 84.5 µM 0.313517093459223 0.378798890665748 no 1232 0.376943918066403 1757 1948547
SGTC_2228 7354201 200 µM 0.313421958492658 0.378834992645382 no 1233 0.376980051785581 1843 753451
SGTC_2552 juarezic acid 87.02 µM 0.311645221993994 0.379509425568927 no 1234 0.377655081194288 1763 1549512
SGTC_1266 0828-0227 32.9 µM 0.311584876288062 0.379532338698738 no 1235 0.377678014707264 1823 3913820
SGTC_1116 jasmonic acid 1.58368 µM 0.310211134903009 0.380054059528083 no 1236 0.378200201751193 1829 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2839 9003951 25.97 µM 0.309754958650847 0.380227354923951 no 1237 0.378373652894862 1841 2990634
SGTC_1758 st042942 75.2445 µM 0.309602660524958 0.380285216347093 no 1238 0.378431566419173 1865 669317
SGTC_2702 st077768 96.8 µM 0.308525623467928 0.380694482916015 no 1239 0.378841202920921 1715 6484119
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.307680959405496 0.381015542828695 no 1240 0.379162554764843 1872 16725076
SGTC_623 k072-0108 16.9 µM 0.307094001313025 0.381238696018207 no 1241 0.379385911755588 1790 5382803
SGTC_2179 6298986 200 µM 0.306152343616015 0.381596783473246 no 1242 0.379744327775294 1910 738374
SGTC_3269 9137823 49.47 µM 0.303696540184312 0.38253113657098 no 1243 0.38067954706043 1736 17682936
SGTC_1237 0330-0133 46.1 µM 0.30287895452644 0.38284235333235 no 1244 0.380991055175729 1766 X1237 YHR072W ERG7
SGTC_2727 riluzole 51.77 µM 0.302734806506588 0.382897231617351 no 1245 0.38104598498361 1845 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2341 7987486 176.74 µM 0.302626252976 0.382938560352124 no 1246 0.381087352549269 1914 1258686
SGTC_221 trifluoperazine 10.304 µM 0.302613437656304 0.382943439516299 no 1247 0.38109223629937 1778 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2606 farnesol 9.78 µM 0.301403283491431 0.383404263918698 no 1248 0.381553495400161 1879 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1579 chlormadinone acetate 49.4 µM 0.300868223826101 0.383608066265267 no 1249 0.381757490984771 1899 45114258 A steroidal progestin.
SGTC_1187 1391-0724 117 µM 0.300524825233 0.383738882553304 no 1250 0.381888431627802 1799 6997986
SGTC_2383 9036125 200 µM 0.299623614147983 0.384082258211802 no 1251 0.382232134890304 1802 79580
SGTC_3352 9151559 45.5865 µM 0.297852040339474 0.384757520883165 no 1252 0.38290804682324 1759 17159339
SGTC_3146 9095609 49.47 µM 0.297628595944897 0.384842715039203 no 1253 0.382993323364799 1845 17173999
SGTC_1380 2291-0730 164 µM 0.296735108876946 0.385183436430976 no 1254 0.383334375300839 1739 2999191
SGTC_2034 5197015 53.07 µM 0.296225768973195 0.385377707251349 no 1255 0.383528835344832 1895 780676
SGTC_54 0159-0055 9 µM 0.29571723406978 0.385571699728708 no 1256 0.383723017321837 1909 3319099
SGTC_2830 7992007 71.43 µM 0.295515228497618 0.385648767404294 no 1257 0.383800160431903 1713 1952075
SGTC_1162 k048-0130 20.1 µM 0.295364560181758 0.385706252208154 no 1258 0.383857701558507 1782 6797406
SGTC_475 α-linolenic acid 10 µM 0.295036969462305 0.385831247255028 no 1259 0.383982819239156 1874 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2564 betulinic acid 100 µM 0.294815502227334 0.385915756693948 no 1260 0.384067411719497 2001 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_744 1594-0068 283 µM 0.294340477829209 0.386097038988965 no 1261 0.384248872497155 1765 668392
SGTC_1274 0865-0114 173 µM 0.293877784001131 0.38627363951406 no 1262 0.384425647353544 1804 870624
SGTC_1227 3909-8010 46.6 µM 0.292501504267128 0.386799075759416 no 1263 0.38495160495497 1807 15982272
SGTC_886 0866-0150 153 µM 0.291212727019641 0.387291293507828 no 1264 0.385444314722173 1935 271463
SGTC_2628 lathosterol 100 µM 0.290591697030499 0.387528545874979 no 1265 0.385681805496092 1796 6710616
SGTC_13 0199-0087 65 µM 0.289651720217767 0.38788772552344 no 1266 0.386041347617819 1838 4589825
SGTC_307 1501-1223 22.3 µM 0.289335634949688 0.388008528154122 no 1267 0.386162272577003 1812 2830329
SGTC_301 4119-0100 24.5 µM 0.288566975353345 0.38830234251035 no 1268 0.386456385336588 1814 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1850 st056238 17 µM 0.287120860963909 0.388855282037121 no 1269 0.387009889809552 1809 5393177
SGTC_1526 st051518 75 µM 0.285585791549931 0.389442481030329 no 1270 0.387597693564889 1777 673993
SGTC_516 3992-2719 87.3 µM 0.282744518431412 0.390529998005762 no 1271 0.388686343647965 1691 5350887 YDR037W KRS1
SGTC_2845 9003024 42.97 µM 0.282160615393845 0.390753597372527 no 1272 0.388910178086507 1885 2990173
SGTC_1897 st060201 15 µM 0.280373362137723 0.391438230951185 no 1273 0.389595535868409 1759 611878
SGTC_2051 5263410 176 µM 0.279512820066888 0.39176799434478 no 1274 0.389925650471688 1906 227584
SGTC_665 3914-0008 307 µM 0.279057048885522 0.391942679326903 no 1275 0.390100522127558 1766 1069549
SGTC_1631 benzylvanillin 81.9 µM 0.27821926966854 0.392263834638197 no 1276 0.390422021769339 1831 75506
SGTC_921 1561-0023 372 µM 0.27727276407071 0.392626757548161 no 1277 0.390785335557943 1742 24050882
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.275909288437316 0.393149725241283 no 1278 0.3913088697952 1783 75037 A free radical scavenger.
SGTC_1932 st074806 40.9 µM 0.275233988219774 0.393408811398439 no 1279 0.391568238065297 1873 17251235
SGTC_1647 st011722 22.4 µM 0.272575067767584 0.394429392530129 no 1280 0.392589939738689 1868 2854783
SGTC_824 1304-0008 100 µM 0.271507064442298 0.394839531860663 no 1281 0.393000533530652 1828 768245
SGTC_1178 0988-0033 191 µM 0.270595477679526 0.395189695644819 no 1282 0.393351087199416 1886 5392207
SGTC_614 0462-0418 107 µM 0.269289235411636 0.395691604199398 no 1283 0.393853557612784 1862 5188303
SGTC_990 3985-0011 41.3 µM 0.269183868506742 0.395732097772033 no 1284 0.393894096670498 1828 5399565 YGL099W LSG1
SGTC_828 2074-0507 139 µM 0.268877246657401 0.395849942067118 no 1285 0.394012073467546 1927 X828
SGTC_1862 st057513 3.81 µM 0.268151968247389 0.396128726950038 no 1286 0.394291172589404 1809 5393163
SGTC_3338 9144300 39.5675 µM 0.26786861349749 0.396237658215161 no 1287 0.394400226936101 1888 4901274
SGTC_84 0443-0269 128.823 µM 0.267500719898562 0.396379101194385 no 1288 0.394541829980947 1909 6150058
SGTC_2088 5278280 127.392 µM 0.267257004700518 0.396472809177647 no 1289 0.394635644164853 1858 791502
SGTC_209 4077-0173 175.592 µM 0.266550136917083 0.396744632169384 no 1290 0.394907775915693 1865 15993494
SGTC_940 3232-1287 54.8 µM 0.26626271837717 0.39685517210141 no 1291 0.39501844170496 1980 1585493 YIL048W NEO1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.265571660538672 0.397120983874061 no 1292 0.39528455682449 1846 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_224 benfluorex 43.875 µM 0.264431003957346 0.39755983594722 no 1293 0.395723911888259 1936 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1481 3346-2004 36 µM 0.263129224552425 0.398060836266205 no 1294 0.396225489727053 1882 2770522
SGTC_2187 6125751 200 µM 0.261685020184552 0.398616846678948 no 1295 0.396782145181805 1876 874498
SGTC_2658 polymyxin b sulfate 77.05 µM 0.261570905307481 0.398660789042928 no 1296 0.396826138708629 1842 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1716 st033144 30.6155 µM 0.258273835289328 0.399930948733853 no 1297 0.398097788907173 1966 674617
SGTC_1394 3474-0001 65.7 µM 0.258215315504001 0.399953502441239 no 1298 0.398120369283932 1833 5017666 YIL048W NEO1
SGTC_758 0868-0029 16 µM 0.254857449508555 0.401248191165185 no 1299 0.399416600801317 1971 762687
SGTC_2505 galangin 7.89 µM 0.253617197911049 0.401726668783027 no 1300 0.399895654471619 1795 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2254 7938975 95.19 µM 0.252705932389473 0.402078320561827 no 1301 0.400247731633631 1944 2969277
SGTC_2140 5586273 200 µM 0.252553367900439 0.402137202018041 no 1302 0.400306684484192 1885 854421
SGTC_3226 9131256 49.47 µM 0.251674805831207 0.402476321573953 no 1303 0.400646216158325 1886 17178073
SGTC_798 1287-0182 476 µM 0.251283497765712 0.402627387723602 no 1304 0.400797466403814 1986 1649755
SGTC_3093 9117344 49.47 µM 0.251149353197758 0.402679178154654 no 1305 0.400849320021459 1881 24824913
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.249455466103492 0.40333329942815 no 1306 0.401504242535335 1993 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_413 propylparaben 100 µM 0.247595701053446 0.404051788639195 no 1307 0.402223618622174 1832 7175 A pharmaceutical preservative.
SGTC_1190 1486-1332 13 µM 0.245722727225167 0.404775708122344 no 1308 0.402948438858889 1906 4150046
SGTC_1359 1582-0056 520 nM 0.244620034877033 0.40520206024956 no 1309 0.403375324848218 1917 3661189
SGTC_1297 1068-0111 14.1 µM 0.244408792021326 0.405283749417308 no 1310 0.403457116588371 1806 767057
SGTC_2723 salbutamol 83.58 µM 0.244296115108802 0.405327324096805 no 1311 0.403500746019467 1958 9884233 β2-adrenoceptor agonist
SGTC_281 1672-3440 14.9 µM 0.243696949586852 0.405559054489575 no 1312 0.403732768018187 1967 6833000
SGTC_2519 cryptotanshinone 88.04 µM 0.242779798797606 0.405913831437625 no 1313 0.404087992835337 1942 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1520 flindersine 88 µM 0.242769386436954 0.405917859644328 no 1314 0.404092026137115 2005 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1891 st059073 26.2 µM 0.241004404384909 0.40660081792458 no 1315 0.404775851460614 2026 688754
SGTC_2313 7726885 200 µM 0.240789957536763 0.406683817350984 no 1316 0.404858956691982 1875 726423
SGTC_2442 5158906 48.48 µM 0.240223425010897 0.406903108040804 no 1317 0.405078527378345 1968 1893835
SGTC_2935 9038016 29.96 µM 0.238679409988928 0.407500905960646 no 1318 0.405677091910466 2012 6463195
SGTC_492 tmb-8 126 µM 0.238424513671881 0.407599615194985 no 1319 0.405775928196774 2003 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2553 4-methylesculetin 85.09 µM 0.237834504852658 0.407828120077623 no 1320 0.406004727704086 1829 5319502
SGTC_1408 3909-7976 48.8 µM 0.236790488595222 0.408232534573343 no 1321 0.406409665374061 1912 24152374
SGTC_501 nsc-95397 161 µM 0.236737470294936 0.408253074575591 no 1322 0.406430232007324 1973 262093
SGTC_3294 9122953 26.2835 µM 0.236302368363829 0.408421648431118 no 1323 0.406599024642587 1883 16459826
SGTC_2111 5486399 200 µM 0.236221841996681 0.408452849049327 no 1324 0.406630265796095 1866 689674
SGTC_3350 9150499 3.57 µM 0.234186492149928 0.409241654656335 no 1325 0.407420100589719 1902 4910996 YPR165W RHO1
SGTC_2460 5552655 174.22 µM 0.234160443580917 0.409251752242494 no 1326 0.40743021140524 1856 5401989
SGTC_3051 9093778 49.47 µM 0.234058228496677 0.409291375945836 no 1327 0.407469887034948 1973 17217378
SGTC_958 1222-0007 33 µM 0.233677309534468 0.409439047437279 no 1328 0.40761775223515 1943 7312461
SGTC_253 dyclonine 31.25 µM 0.231205468587706 0.41039762151035 no 1329 0.408577590888467 1938 3180 An oral anasthetic.
SGTC_1637 st007924 17.4 µM 0.230307485285436 0.41074599023194 no 1330 0.408926422261265 1864 683336
SGTC_1547 harmine 94.2 µM 0.23028258606096 0.410755650782529 no 1331 0.408936095664862 1902 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2502 avocadyne acetate 18.59 µM 0.229642553467455 0.411003993035398 no 1332 0.409184768759585 1973 3952079
SGTC_2753 fluvastatin 17.09 µM 0.229353837828184 0.411116030718527 no 1333 0.409296955971317 1924 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2452 5863136 48.41 µM 0.228840395791994 0.411315292615561 no 1334 0.409496484226253 1882 2184096
SGTC_2467 5474540 200 µM 0.227614040089563 0.411791321920724 no 1335 0.409973152012234 1924 5413519
SGTC_1420 4'-methoxyflavone 42 µM 0.227333870785017 0.41190009230063 no 1336 0.410082068709309 2017 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_858 0438-0351 2.77 µM 0.227310297657847 0.411909244425749 no 1337 0.410091233153052 1881 2799119
SGTC_704 1310-0270 142 µM 0.226876405084469 0.412077709165804 no 1338 0.410259924845012 1847 5718033
SGTC_1278 0874-0585 172 µM 0.226472411921824 0.412234579617911 no 1339 0.410417006971979 1943 766306
SGTC_1017 4239-0030 168 µM 0.226011830046985 0.412413440560115 no 1340 0.410596109664966 1826 1149593
SGTC_2925 9010536 32.5 µM 0.224981450958619 0.412813640607694 no 1341 0.410996852181569 1946 2994177
SGTC_37 0566-0070 1.56 µM 0.223594646167092 0.413352419699986 no 1342 0.411536364973552 1988 1626686
SGTC_2900 5328528 85.29 µM 0.222344620007024 0.413838199646877 no 1343 0.412022809774887 1909 795359
SGTC_479 n-linoleoylglycine 10 µM 0.221314002727542 0.414238813056796 no 1344 0.412423973848683 1898 6433346 An anti-infammatory.
SGTC_3349 9149703 23.001 µM 0.219751110649189 0.414846498280788 no 1345 0.41303249845299 1985 4910494
SGTC_583 1488-1091 88.9 µM 0.219695984386245 0.414867936258003 no 1346 0.413053966131782 2068 4303273
SGTC_229 benomyl 22.8748 µM 0.218415885855141 0.4153658231987 no 1347 0.413552544598075 1926 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_634 1611-4317 11.2 µM 0.218277077170983 0.415419820218864 no 1348 0.413606616814003 2065 2843522
SGTC_2669 eugenol 100 µM 0.216536071106719 0.41609721246022 no 1349 0.414284955676447 2035 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1966 st070145 16.1 µM 0.215278844981392 0.41658653030674 no 1350 0.414774961107125 1909 3748532
SGTC_3236 9132701 49.47 µM 0.214714205209009 0.416806332663375 no 1351 0.414995073360323 1895 24282524
SGTC_2099 5377090 177.372 µM 0.212568382046911 0.417641893059342 no 1352 0.415831817635912 1905 2243829
SGTC_1554 st069299 38.7 µM 0.211728609683962 0.417968992841568 no 1353 0.416159383388179 1982 24207999
SGTC_2266 7929956 200 µM 0.211490051157106 0.418061924148209 no 1354 0.416252447337693 1993 2967153
SGTC_1615 st002656 86.5 µM 0.21148413001501 0.418064230807982 no 1355 0.41625475729126 1963 1584458
SGTC_2238 6671620 73.2395 µM 0.210952961026084 0.418271166220278 no 1356 0.416461988482465 1993 729941
SGTC_2879 9041815 71.43 µM 0.210427631888403 0.418475848768186 no 1357 0.416666964144511 2044 4942971
SGTC_519 k048-0011 62.8 µM 0.210267070660807 0.418538412205277 no 1358 0.416729617285266 1936 6836379
SGTC_572 0960-0087 17.7 µM 0.209349534800814 0.418895973855814 no 1359 0.417087692597964 1892 6796365
SGTC_1027 k015-0025 8.67 µM 0.207989984058315 0.419425910827608 no 1360 0.417618393954864 1880 3598955
SGTC_2308 7584454 197.62 µM 0.207932716468342 0.419448236279231 no 1361 0.417640751689921 2024 893577
SGTC_894 0960-0238 55.9 µM 0.207282691625665 0.419701663010109 no 1362 0.417894545344224 2041 6741907 YDL195W SEC31
SGTC_1032 k061-1018 98.7 µM 0.206910510033815 0.419846781333353 no 1363 0.418039874156431 2079 4005393
SGTC_2472 5377652 49.4 µM 0.206632945447967 0.419955014382473 no 1364 0.418148264373656 1902 1610903
SGTC_435 c-PAF 6.7 µM 0.206453168488886 0.420025119526538 no 1365 0.418218471401281 2064 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.206429179929276 0.420034474206601 no 1366 0.418227839681343 2032 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_416 estradiol valerate 100 µM 0.205546748205094 0.420378622365352 no 1367 0.418572488966255 1946 13791 A steroid.
SGTC_819 1013-0258 27.7 µM 0.203924978864529 0.421011270582779 no 1368 0.419206062452012 1933 5753198
SGTC_1763 st044482 94.5 µM 0.201865315337118 0.421815034144326 no 1369 0.420011009091756 1998 88505
SGTC_2667 digitoxin 100 µM 0.201312862991948 0.422030678826984 no 1370 0.420226972621736 2072 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_302 1094-0063 18.9 µM 0.200855743285024 0.422209128970902 no 1371 0.420405687076495 1937 5440289
SGTC_2719 novobiocin 32.65 µM 0.200345591557719 0.42240830058204 no 1372 0.420605154180094 2049 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1137 ixabepilone 100 µM 0.19888990958525 0.422976731642739 no 1373 0.421174431409853 1868 154225 A novel microtubule stabilizer.
SGTC_215 1287-0124 461.5 µM 0.198143269864489 0.42326835022138 no 1374 0.421466485724357 2069 5560863
SGTC_1550 gossypolone 36.6 µM 0.19762409329367 0.423471152240741 no 1375 0.4216695914215 2060 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_931 2812-0076 566 µM 0.197365620840697 0.423572124944314 no 1376 0.421770715521778 1894 3450959
SGTC_3068 9116768 49.47 µM 0.197157903780385 0.423653273605068 no 1377 0.421851985951337 1953 41904888
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.1960455220485 0.424087901921059 no 1378 0.422287267909346 1843 641818 YHR062C RPP1
SGTC_3025 9087895 49.47 µM 0.196026069078692 0.424095503382734 no 1379 0.422294880824733 2070 17173641
SGTC_590 k048-0076 22.4 µM 0.195772212989986 0.42419470302613 no 1380 0.42239423000858 2058 6832814
SGTC_2272 7805186 180 µM 0.195259376782307 0.424395119281699 no 1381 0.422594948774574 2092 2956062 YPR165W RHO1
SGTC_3168 9103419 49.47 µM 0.19508307493444 0.424464022515974 no 1382 0.422663956132297 2075 16649256
SGTC_160 3453-0671 289.699 µM 0.194887939833081 0.424540288954915 no 1383 0.422740337893302 1970 5322268
SGTC_1567 st069303 68.4 µM 0.194461311639161 0.424707041796455 no 1384 0.422907343143165 1941 5581319
SGTC_1228 0124-0032 52.5 µM 0.194058215464943 0.424864609242235 no 1385 0.423065149424232 2032 X1228
SGTC_2614 arthonioic acid 13.39 µM 0.192602921023029 0.425433573289002 no 1386 0.423634978558956 2023 6710684
SGTC_2270 7924575 90.91 µM 0.192447586344198 0.425494312357208 no 1387 0.423695810225615 2093 1262135
SGTC_2222 6885208 172.143 µM 0.192406509372877 0.425510374597205 no 1388 0.42371189696092 2003 609514
SGTC_462 ag-879 158 µM 0.191617517518554 0.425818916350719 no 1389 0.424020909894387 2076 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_577 r071-0003 38.6 µM 0.191402793204418 0.425902893930742 no 1390 0.424105015930769 2001 4568517 YMR134W ERG29
SGTC_1147 3809-1045 12.3 µM 0.19067865410069 0.426186125782853 no 1391 0.424388681699048 1938 325925
SGTC_543 3844-1095 191 µM 0.190146999238864 0.426394095702313 no 1392 0.424596970890171 2026 4230703
SGTC_2018 5133068 143 µM 0.189252584779227 0.426744014145527 no 1393 0.424947427778438 1969 785362
SGTC_1244 0416-0015 52.5 µM 0.187856998482809 0.427290119263527 no 1394 0.425494376374622 1961 96201
SGTC_3018 9082602 49.47 µM 0.187720353072969 0.427343597314367 no 1395 0.425547937230144 1977 17332089
SGTC_1442 4112-3290 3 µM 0.187334016458752 0.427494802654968 no 1396 0.425699376893702 2047 704353
SGTC_975 1335-0046 28.5 µM 0.18669571737904 0.427744644987869 no 1397 0.425949607050283 1891 16486740
SGTC_3207 9114163 49.47 µM 0.186674703572253 0.427752870682508 no 1398 0.425957845527068 2103 849233
SGTC_1590 st077108 57.8 µM 0.185092558558693 0.428372279234149 no 1399 0.4265782190871 2087 5489485
SGTC_320 4092-0846 5.34 µM 0.184514653531156 0.428598572696715 no 1400 0.426804866329357 2048 1359356
SGTC_142 0335-0849 62.6745 µM 0.184048768112664 0.428781019117958 no 1401 0.426987598458338 2011 3889043 YPR107C YTH1
SGTC_1895 st058434 18.3 µM 0.183544046041286 0.428978691621305 no 1402 0.427185580993585 2105 5393175
SGTC_892 0929-0076 29 µM 0.183153840752028 0.429131526269618 no 1403 0.427338655691893 1931 5751038
SGTC_427 1354-0053 47.3 µM 0.182922529528854 0.429222130698362 no 1404 0.427429402569521 2044 6813657
SGTC_1759 st043059 70 µM 0.18270383676771 0.429307795914751 no 1405 0.427515202565751 1921 669426
SGTC_2284 7945075 39.21 µM 0.182229312724869 0.429493685504214 no 1406 0.427701384943508 2104 1245402
SGTC_2943 9068529 45.32 µM 0.181370991771625 0.429829963012966 no 1407 0.42803819323158 2057 3270634
SGTC_3140 9094243 49.47 µM 0.17942543902909 0.430592390051242 no 1408 0.428801829019581 2156 19291112
SGTC_2473 5854593 8.94 µM 0.179049358588837 0.430739799130373 no 1409 0.428949472654185 1945 2872951
SGTC_3172 9105863 49.47 µM 0.178968936288352 0.43077132283458 no 1410 0.428981046554378 2091 2348785
SGTC_42 0133-0086 60.653 µM 0.178494522176447 0.43095729129606 no 1411 0.429167311395189 2002 162923 Model of phenazepam hydroxylation.
SGTC_2921 7974240 10.71 µM 0.177007941251107 0.431540124120518 no 1412 0.42975107593051 2031 2979074 YDR527W RBA50
SGTC_1492 4158-0558 28.5 µM 0.176842413257059 0.4316050307078 no 1413 0.429816086543631 2088 3967268
SGTC_1820 st053765 18.6 µM 0.176429557919325 0.431766926963027 no 1414 0.429978242502953 1941 3690829
SGTC_581 0958-0271 211 µM 0.176380443412076 0.431786187389686 no 1415 0.429997533848133 1961 4591145
SGTC_1602 st001878 87.6 µM 0.17455097198467 0.432503736169466 no 1416 0.430716237848787 2060 595405 YLR310C CDC25
SGTC_512 prima-1 270 µM 0.173796185069428 0.432799841027051 no 1417 0.431012821321002 2078 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_396 dithiazanine 1.25 µM 0.171458732133414 0.433717068531426 no 1418 0.431931538432456 1948 10578 An antihelmenthic.
SGTC_1790 st045711 43.5 µM 0.171338745547705 0.433764161507627 no 1419 0.431978708175656 2114 585119
SGTC_2922 7999257 32.47 µM 0.170314242570202 0.434166302131716 no 1420 0.432381505473655 2073 2988377
SGTC_1062 mesoridazine 14.2 µM 0.170307483982701 0.43416895525709 no 1421 0.432384162938202 2077 4078 A neuroleptic.
SGTC_1618 st003135 44.5 µM 0.170218210624533 0.434204000344857 no 1422 0.432419265350357 2100 1270615
SGTC_74 000s-0487 160.283 µM 0.168930977612591 0.43470937299555 no 1423 0.432925466373799 2147 677548
SGTC_3187 9109394 49.47 µM 0.167881119791663 0.435121630266981 no 1424 0.433338401767454 1961 17098090
SGTC_1411 3909-8223 150 µM 0.16788071905884 0.435121787639898 no 1425 0.433338559399642 2120 X1411
SGTC_1179 1021-1431 9.29 µM 0.167730412034881 0.435180815859896 no 1426 0.433397684890012 2033 2840958
SGTC_1094 duloxetine 25.4 µM 0.165963980625291 0.435874632531633 no 1427 0.434092648152587 2006 60834 A selective serotonin reuptake inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM 0.165394989384163 0.436098162320365 no 1428 0.43431654862832 1985 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2673 kobusone 100 µM 0.164616077555338 0.436404193078561 no 1429 0.434623087902123 2068 6710676 An epoxy ketone and protein crosslinker.
SGTC_3281 9140613 49.47 µM 0.164297956965529 0.436529192107644 no 1430 0.434748294972729 1914 16013766
SGTC_2621 lithochol-11-enic acid 100 µM 0.163388008573549 0.436886772812415 no 1431 0.435106471893889 2130 6708711
SGTC_552 k242-0005 476 µM 0.163111463877826 0.436995456291931 no 1432 0.435215336904676 2009 4088318
SGTC_1150 3909-7983 10.9 µM 0.163097768486093 0.437000838774559 no 1433 0.435220728381363 1986 23965914
SGTC_1742 st038235 28.8875 µM 0.162866597185451 0.437091694123818 no 1434 0.435311735603325 2005 564103 YBR002C RER2
SGTC_418 lividomycin a 100 µM 0.162268559228998 0.437326751430977 no 1435 0.435547186307586 2122 72394 An antibiotic.
SGTC_14 0354-0009 295 µM 0.162146113233741 0.437374881251143 no 1436 0.435595396763921 2049 1713507
SGTC_432 NS 1619 61.3 µM 0.160653214644667 0.437961768888116 no 1437 0.436183269989302 1999 4552 A K+/calcium channel activator.
SGTC_2291 7917025 104.35 µM 0.160547583506626 0.438003299740011 no 1438 0.436224870748534 1975 2964612
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.160110985747897 0.438174963530481 no 1439 0.436396823722101 1992 5282362
SGTC_1123 mangostin 811.285 nM 0.15749191938661 0.439204984858863 no 1440 0.43742858791029 1976 5281650 An antioxidant.
SGTC_517 1365-0151 113 µM 0.157209970759805 0.43931589374053 no 1441 0.437539685242462 2031 768657
SGTC_1021 4476-0760 85.3 µM 0.156912931170578 0.439432744040139 no 1442 0.437656734252991 1920 746768
SGTC_1808 st050063 61.5 µM 0.155930724168396 0.439819165016008 no 1443 0.438043813566367 2120 4011993
SGTC_3099 9120367 49.47 µM 0.155813445041788 0.439865308940187 no 1444 0.438090036228672 2069 24824940
SGTC_1812 st052057 4.327 µM 0.155119695086453 0.44013828422052 no 1445 0.438363477842338 2073 3645418
SGTC_509 pifithrin 175 µM 0.154818438893832 0.440256830745746 no 1446 0.438482227172036 2139 4817 A p53 inhibitor.
SGTC_2885 9057732 51.95 µM 0.151604888486713 0.441521717607539 no 1447 0.439749288762504 2047 6471414
SGTC_2324 6149169 200 µM 0.151496993154884 0.44156419675663 no 1448 0.439791841288982 2123 2888231
SGTC_2529 gangaleoidin 93.61 µM 0.151427865233673 0.441591413257496 no 1449 0.43981910481462 2047 4565183
SGTC_2892 9047358 58.44 µM 0.150364420260623 0.442010139117896 no 1450 0.440238555301365 2032 6466771
SGTC_2779 methotrexate 400 µM 0.14990303709309 0.442191826496236 no 1451 0.440420557770501 2144 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2032 5185112 25.99 µM 0.149499415273735 0.442350778094681 no 1452 0.440579785363373 2114 5718189
SGTC_3270 9137563 49.47 µM 0.148366683904886 0.44279691214745 no 1453 0.441026695717113 2111 17015724
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.147530659483936 0.443126232684632 no 1454 0.441356590860912 2077 364106
SGTC_1748 st037455 53.6035 µM 0.146394360467196 0.443573898114772 no 1455 0.441805039522529 2048 580690
SGTC_3044 9093193 49.47 µM 0.145692541857582 0.443850428190745 no 1456 0.44208205464035 1999 25236277
SGTC_880 0833-0487 87.2 µM 0.145678287997982 0.443856044770242 no 1457 0.442087681081197 2076 76075
SGTC_2507 purpurin 79.67 µM 0.14525290735632 0.444023666605019 no 1458 0.442255597396968 1958 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_907 3448-6986 75.5 µM 0.143101026950718 0.444871770925878 no 1459 0.443105196950572 2135 590582
SGTC_2412 st077135 33.4 µM 0.143038652802483 0.444896357759384 no 1460 0.443129827262473 2113 13258915
SGTC_1872 amphotericin b 148 nM 0.14226820169748 0.445200073997195 no 1461 0.443434081188694 2128 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_691 1548-0686 185 µM 0.141305865840396 0.445579477467133 no 1462 0.443814157921599 2022 46495133
SGTC_2025 5147754 141 µM 0.140612189477586 0.445852992151325 no 1463 0.444088159053974 2147 315777 YLR208W SEC13
SGTC_354 2783-3500 4.88 µM 0.140441739774532 0.445920203950056 no 1464 0.444155490528895 1995 6740761
SGTC_2957 9076800 11.52 µM 0.139784514637602 0.446179375774515 no 1465 0.444415124345054 2045 16459615
SGTC_2030 5175110 200 µM 0.13779894601218 0.446962509165137 no 1466 0.445199658686965 2103 2831986
SGTC_774 k060-0086 136 µM 0.136730739540526 0.44738390908969 no 1467 0.445621815537187 2176 5911235
SGTC_962 1254-0300 21.5 µM 0.135787928349746 0.447755890827929 no 1468 0.445994467224101 2072 7340576
SGTC_76 0433-0009 400.328 µM 0.132474300272659 0.449063629676931 no 1469 0.447304574631875 1994 2841569
SGTC_1853 st056710 91.2 µM 0.132324086076442 0.449122925635672 no 1470 0.447363978476166 2207 269167
SGTC_3327 9140648 26.9345 µM 0.131798413634984 0.449330439936695 no 1471 0.447571870671258 2159 8029710
SGTC_3334 9142812 21.919 µM 0.131726399313778 0.449358869369965 no 1472 0.447600351916403 2128 45283678
SGTC_3123 9126162 49.47 µM 0.130849295954762 0.44970514842195 no 1473 0.44794726283438 2129 25239884
SGTC_90 0870-0863 4.608 µM 0.130510723916529 0.449838826400487 no 1474 0.448081185125586 2092 1738164
SGTC_2569 tetrandrine 100 µM 0.130290283853513 0.4499258655381 no 1475 0.448168383453373 1972 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_422 cantharidin 155 µM 0.129527853302343 0.450226924181563 no 1476 0.448469993420724 2060 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1628 st004252 77.7 µM 0.12858423237683 0.450599568565652 no 1477 0.448843321731689 2148 692968
SGTC_1423 4048-0112 5.59 µM 0.125776044834333 0.45170880346064 no 1478 0.449954602307518 2183 X1423
SGTC_391 gliotoxin 8.33 µM 0.125235255095155 0.451922459137376 no 1479 0.450168653707251 2118 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2348 9022543 33.42 µM 0.124999943134364 0.452015430741369 no 1480 0.450261797679449 2102 3162678 YDL140C RPO21
SGTC_2138 5575593 77.673 µM 0.124994201039054 0.452017699472435 no 1481 0.450264070618007 2115 762213
SGTC_1708 st033234 31.827 µM 0.124226219633281 0.452321146922042 no 1482 0.450568081383007 2145 674664
SGTC_3139 9095020 49.47 µM 0.12409213396566 0.452374130172305 no 1483 0.450621163103479 2195 25236292
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.123810537951008 0.452485404124431 no 1484 0.450732643969208 2128 7104
SGTC_3312 9133330 71.43 µM 0.122800082400349 0.452884720913627 no 1485 0.451132704504363 2164 17617324
SGTC_1090 efavirenz 20.7 µM 0.121520172038549 0.453390590535627 no 1486 0.451639519063612 2121 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2807 7945238 51.95 µM 0.121512416295527 0.453393656133865 no 1487 0.451642590397523 2120 17148797
SGTC_999 SEC7.066 22.7 µM 0.119025809346087 0.454376674872361 no 1488 0.45262745411372 2108 740511 YDR170C SEC7
SGTC_192 3455-0609 60.9 µM 0.118571275688913 0.454556393938073 no 1489 0.452807511727372 2139 3769639
SGTC_1327 1436-0082 2.18 µM 0.117803806297026 0.454859866451253 no 1490 0.453111556781126 2071 15992205
SGTC_864 0469-0573 172 µM 0.117646116394387 0.454922223413226 no 1491 0.453174031523029 2011 689425
SGTC_17 0960-0276 49.807 µM 0.117396991806 0.455020739609144 no 1492 0.453272733890501 2202 6821114
SGTC_1624 st003710 6.25 µM 0.117208332901659 0.4550953465211 no 1493 0.453347481867897 2175 24207033
SGTC_701 4424-0219 185 µM 0.116570104224925 0.455347751692662 no 1494 0.453600364772 2213 2911779
SGTC_2310 7668677 200 µM 0.115604898518663 0.455729503179481 no 1495 0.453982840241906 2138 2197143
SGTC_1749 st037932 54.2 µM 0.115534217006773 0.455757460252878 no 1496 0.454010850403072 2108 594497
SGTC_1661 st013063 9.66 µM 0.115210332769329 0.455885570886747 no 1497 0.454139204424901 2185 721395
SGTC_2390 9097792 176.6 µM 0.113809362698895 0.456439769575161 no 1498 0.454694458230489 2036 4497149
SGTC_1391 3442-0225 151 µM 0.113796559053931 0.45644483486041 no 1499 0.454699533176076 2130 5227075
SGTC_2182 6325192 200 µM 0.112590077125038 0.456922166141091 no 1500 0.455177776165843 2220 736248
SGTC_349 k015-0014 24 µM 0.110955395195125 0.457569009073843 no 1501 0.455825858865216 2114 2196908
SGTC_1151 3909-8316 15.3 µM 0.110896756494357 0.457592214481111 no 1502 0.455849108840542 2119 800431
SGTC_268 camptothecin 39.6153 µM 0.110873139015605 0.457601560793376 no 1503 0.455858473105025 2215 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2809 7964133 12.99 µM 0.11068604220708 0.45767560276774 no 1504 0.455932657334147 2118 1253665
SGTC_2235 salicylic acid 500 µM 0.109584022136713 0.458111747582478 no 1505 0.456369641410715 2221 338 A COX inhibitor and kinase inhibitor.
SGTC_1132 3456-3614 2.5 µM 0.109216006708888 0.458257407751904 no 1506 0.456515582368381 2214 3125502
SGTC_324 1315-0088 19.6 µM 0.109160229982322 0.458279484618892 no 1507 0.456537701814573 2185 6787421
SGTC_706 4262-0057 46.9 µM 0.107601677359943 0.458896423800275 no 1508 0.457155833188856 2195 883298
SGTC_2941 9056145 11.23 µM 0.107462706275147 0.458951439096839 no 1509 0.457210955015651 2250 2119517
SGTC_787 4152-0075 138 µM 0.107256258437653 0.459033168261496 no 1510 0.45729284250413 2077 9566539
SGTC_673 1082-0474 110 µM 0.106892480412775 0.45917718596564 no 1511 0.457437139386581 2174 3098046
SGTC_1958 st076513 41.9 µM 0.106678063995827 0.45926207474769 no 1512 0.457522192839403 2141 732122 YGL099W LSG1
SGTC_1864 st057645 30.4 µM 0.105777017302182 0.459618824950424 no 1513 0.457879636003755 2236 688666
SGTC_2923 7992654 58.14 µM 0.105620801159724 0.459680678712517 no 1514 0.457941610063914 2126 2985126
SGTC_1934 st074720 32.6 µM 0.105399180899512 0.459768430900797 no 1515 0.458029532996377 2198 17250992
SGTC_684 1140-0066 328 µM 0.105145918327468 0.459868714496826 no 1516 0.458130011829941 2114 6813534
SGTC_2356 9061756 188.97 µM 0.104708223719989 0.460042033089903 no 1517 0.458303668126359 2210 20104043
SGTC_602 3130-1533 38.1 µM 0.103559938573476 0.460496767788505 no 1518 0.458759290523728 2209 720941
SGTC_246 cycloheximide 667 µM 0.103279863998695 0.46060768854193 no 1519 0.45887042817469 2121 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1799 st045822 46.1415 µM 0.102959898059343 0.46073441162474 no 1520 0.458997399231105 2225 3674992
SGTC_3005 9076496 71.4286 µM 0.102263454207353 0.461010253227469 no 1521 0.459273781252512 2243 21368410
SGTC_728 3030-5151 22.5 µM 0.102228795157501 0.46102398118255 no 1522 0.459287536126074 2197 3125388
SGTC_1462 k081-0014 26.5 µM 0.101385075940859 0.46135818061363 no 1523 0.459622391550208 2201 3270634
SGTC_1539 benzyladenosine 56 µM 0.101188754613149 0.461435947937353 no 1524 0.459700311708401 2203 92208 A nucleotide analog.
SGTC_613 3914-0030 117 µM 0.100713767850556 0.46162410704442 no 1525 0.459888840891864 2202 1145395
SGTC_967 1306-0166 352 µM 0.100696696963724 0.461630869588453 no 1526 0.459895616744323 2234 4437607
SGTC_2369 9071472 200 µM 0.100473499843862 0.461719288999724 no 1527 0.459984210210553 2174 17296037
SGTC_1368 1852-0141 284 µM 0.100037681944306 0.46189194346139 no 1528 0.46015720480737 2139 2838987
SGTC_1154 4088-0362 150 µM 0.0993915031087109 0.462147948126373 no 1529 0.460413714448293 2229 6618304
SGTC_956 1185-0240 191 µM 0.0988608806747782 0.462358183112781 no 1530 0.460624364698317 2160 1416193
SGTC_723 4182-0001 115 µM 0.0987270312862405 0.462411216503647 no 1531 0.460677502923712 2097 744821 YLR208W SEC13
SGTC_2679 rapamycin 1 nM 0.0986825578967802 0.462428837760453 no 1532 0.460695159020823 2154 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_923 1900-2434 73.3 µM 0.0976396754290436 0.462842069960641 no 1533 0.461109209286619 2232 5910570
SGTC_695 3505-6186 243 µM 0.096650507386644 0.463234055398936 no 1534 0.461501972559239 2186 1819379
SGTC_994 3910-0338 138 µM 0.0960572700762478 0.463469159386588 no 1535 0.461737543928432 2201 3479481
SGTC_599 1935-0052 86.5 µM 0.0954018451362977 0.463728923587545 no 1536 0.461997825279001 2235 9557311
SGTC_1202 1988-0068 29.6 µM 0.0951082529434592 0.463845287839141 no 1537 0.462114421446699 2099 2850480
SGTC_1173 0443-0020 122 µM 0.0944308711606979 0.464113777553211 no 1538 0.462383446863138 2145 5331295
SGTC_2323 6148992 148.28 µM 0.0921470073236376 0.465019138563593 no 1539 0.463290620426161 2155 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0883744758020299 0.46651502628075 no 1540 0.464789523632899 2246 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2749 bexarotene 57.39 µM 0.0883534154238345 0.466523378509231 no 1541 0.464797892770443 2151 82146 An retinoic acid receptor inhibitor.
SGTC_618 k072-0232 33.2 µM 0.0881025731974257 0.466622859886935 no 1542 0.464897575609481 2200 5872756 YGL099W LSG1
SGTC_1663 st014140 55.4 µM 0.0876509260407705 0.46680198363227 no 1543 0.465077062387457 2267 4207120
SGTC_2693 st077581 40.7 µM 0.0870512612975308 0.467039821695121 no 1544 0.465315383048682 2266 25238761
SGTC_632 0781-2353 4.65 µM 0.0865572206662834 0.46723577613883 no 1545 0.465511735591597 2192 6811515 YHR007C ERG11
SGTC_473 2-arachidonoylglycerol 10 µM 0.0864403095293953 0.467282148502241 no 1546 0.465558202229029 2092 5282280 An endocannabinoid.
SGTC_521 r062-0005 13.8 µM 0.0859209951853017 0.467488137945045 no 1547 0.465764610741566 2197 2832033
SGTC_2134 5324836 1.464 µM 0.0855670010028254 0.467628557054441 no 1548 0.465905315801257 2206 699272
SGTC_3218 9131285 49.47 µM 0.0855284869563966 0.467643834690314 no 1549 0.465920624562206 2234 17156417
SGTC_62 0180-0423 3.232 µM 0.0851291857671531 0.467802231087174 no 1550 0.466079343816841 2205 30102 YGL099W LSG1
SGTC_2360 9040895 200 µM 0.0851116589627132 0.467809183807217 no 1551 0.466086310715117 2165 4914414
SGTC_16 erodoxin 22.806 µM 0.0850468690852531 0.467834885433254 no 1552 0.466112064757619 2237 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_586 0957-0265 8.15 µM 0.0849254216434113 0.467883063022941 no 1553 0.466160340622095 2260 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3325 9138760 55.175 µM 0.0835612070430986 0.468424272253572 no 1554 0.466702655657888 2172 43844959
SGTC_454 lyso-paf C-16 6.67 µM 0.0833061941751008 0.46852544709179 no 1555 0.466804037588839 2165 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_225 nsc-122657 1.016 µM 0.0830488040277839 0.468627567162749 no 1556 0.466906366805761 2229 275685
SGTC_172 1112-0046 2.638 µM 0.0812151318845759 0.469355139700944 no 1557 0.467635432882704 2170 2802135 YIL048W NEO1
SGTC_3224 9130643 49.47 µM 0.0811726287734123 0.469372005496233 no 1558 0.4676523333711 2218 17644395
SGTC_1334 1486-0610 236 µM 0.0802457724325399 0.469739807935322 no 1559 0.468020893188494 2201 3742339
SGTC_1706 st031321 9.9705 µM 0.0791947645413555 0.470156908395533 no 1560 0.468438854402839 2268 6103185
SGTC_2984 9022109 38.96 µM 0.079189888925996 0.470158843397161 no 1561 0.468440793402262 2279 6459207
SGTC_2408 sulbentine 18.36 µM 0.0782474862357462 0.470532871053036 no 1562 0.46881559461337 2133 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1917 st066507 28.5 µM 0.0775199982761482 0.470821619580282 no 1563 0.469104941409338 2164 3156428
SGTC_1827 berberine 7.24 µM 0.0771200602289695 0.470980366239734 no 1564 0.469264017384574 2192 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1395 3486-0190 4.35 µM 0.0769717292027484 0.47103924416959 no 1565 0.469323017527757 2270 6748079
SGTC_879 0831-1030 162 µM 0.075650177134032 0.471563843607242 no 1566 0.469848707613321 2272 1549252
SGTC_2102 5377816 72.7585 µM 0.0756333563384822 0.471570521060904 no 1567 0.469855398969558 2253 1379702
SGTC_1885 st057546 99.9 µM 0.0735539064786573 0.47239607391079 no 1568 0.470682674518034 2270 702008
SGTC_85 0868-0259 160.055 µM 0.0730584885987958 0.472592775117179 no 1569 0.470879787320358 2221 83173
SGTC_2482 5981709 142.65 µM 0.0706113718266498 0.473564477915678 no 1570 0.471853529798773 2236 877755
SGTC_2335 9018011 154.17 µM 0.0704391221561081 0.473632880926195 no 1571 0.471922076793027 2239 6458208
SGTC_2608 thymoquinone 42.66 µM 0.069593068079587 0.473968873345811 no 1572 0.47225877721793 2292 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3199 9111318 49.47 µM 0.0694511484311063 0.474025235542184 no 1573 0.472315258305332 2248 8548020
SGTC_2584 androsterone 48.74 µM 0.0694173926936561 0.47403864142637 no 1574 0.472328692473289 2292 2754130 A steroid.
SGTC_2870 9038528 12.99 µM 0.0693922486689795 0.474048627240728 no 1575 0.472338699357059 2176 6463316
SGTC_3086 9117350 49.47 µM 0.0693439047671118 0.474067826807522 no 1576 0.47235793943682 2290 2679265
SGTC_686 1319-0111 510 µM 0.0675067279117296 0.474797497700173 no 1577 0.473089153073335 2265 4562600
SGTC_3150 9097574 49.47 µM 0.0657929380282104 0.475478239299342 no 1578 0.473771339346329 2268 17217476
SGTC_1253 0550-0034 176 µM 0.0643261055488643 0.476060942854787 no 1579 0.474355283637113 2234 5969915
SGTC_2707 st078556 66.6 µM 0.0636157427231798 0.476343155073604 no 1580 0.474638098126421 2304 17250899
SGTC_720 r052-1644 49.9 µM 0.0633333512849202 0.476455346560349 no 1581 0.474750529288509 2241 1422863 YOR257W CDC31
SGTC_2195 6536160 144.242 µM 0.0621788734827957 0.476914029149637 no 1582 0.475210193224249 2283 3834386
SGTC_60 0986-0278 202 µM 0.0618587965773261 0.477041203518721 no 1583 0.475337640096701 2185 3110598
SGTC_1930 st074634 34.3 µM 0.061664259416574 0.477118499025516 no 1584 0.475415101316754 2300 684253 YOR116C RPO31
SGTC_3299 9121982 43.1275 µM 0.0616159789344223 0.477137682457014 no 1585 0.475434325885771 2211 17594604 YPL160W CDC60
SGTC_1807 st050092 58.9 µM 0.0598356322744713 0.477845109661576 no 1586 0.47614327297795 2246 5008496
SGTC_2990 9074105 71.4286 µM 0.0587452721395321 0.478278402831254 no 1587 0.47657749981269 2318 6502001
SGTC_624 k048-0052 28 µM 0.0577513263407962 0.478673404737476 no 1588 0.47697335468908 2229 6835531
SGTC_963 1269-2853 151 µM 0.0576119719317174 0.47872878696293 no 1589 0.477028856645637 2254 3668223
SGTC_1824 st053723 68.6 µM 0.0575880271588314 0.478738303135296 no 1590 0.477038393394485 2238 675225
SGTC_2299 7976368 114.88 µM 0.0571795833144513 0.478900629444876 no 1591 0.477201070851047 2282 2979718
SGTC_2799 7812892 81.82 µM 0.0569715851636979 0.478983294718695 no 1592 0.477283915059953 2279 20205235
SGTC_983 1491-0821 12.2 µM 0.0568197630872798 0.479043634352664 no 1593 0.477344385351299 2298 46495113
SGTC_3271 9137798 49.47 µM 0.0549615746978395 0.479782184727658 no 1594 0.478084538222706 2302 6498326
SGTC_2069 5228469 200 µM 0.054642154211797 0.479909147765457 no 1595 0.478211777350653 2254 2835210
SGTC_2955 9076254 12.21 µM 0.0542892535326923 0.480049420857129 no 1596 0.478352355683168 2308 16459619
SGTC_2076 5212012 200 µM 0.0526641186853604 0.480695420881247 no 1597 0.478999764236602 2323 604802
SGTC_752 1896-0090 130 µM 0.0521906950561595 0.480883618984618 no 1598 0.479188373549982 2325 772567
SGTC_1756 st041558 35.5 µM 0.0503721216334793 0.481606588075993 no 1599 0.479912925944236 2330 3955792
SGTC_6 0844-0013 19.835 µM 0.04886425483242 0.482206082543885 no 1600 0.480513737663554 2320 1584900
SGTC_1468 k284-1086 134 µM 0.0488565888141672 0.482209130487028 no 1601 0.480516792313934 2295 15996457
SGTC_1013 4112-3890 241 µM 0.0487774747492287 0.482240585621775 no 1602 0.480548316674124 2214 705171
SGTC_2601 securinine 100 µM 0.0483674856560987 0.482403595851871 no 1603 0.480711685825759 2281 442872 A GABA receptor antagonist.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0479813006027985 0.482557144369939 no 1604 0.480865572698795 2283 2724 A muscle relaxant with antifungal properties.
SGTC_1272 0839-0021 27 µM 0.0476505497022447 0.482688654134153 no 1605 0.480997372459523 2269 5027250
SGTC_1045 1348-1485 165 µM 0.0473295625558957 0.482816283536157 no 1606 0.48112528348255 2325 6810614
SGTC_2001 4023502 57.655 µM 0.0464932619010059 0.483148817713712 no 1607 0.481458552252328 2294 108941 YCR052W RSC6
SGTC_3267 9137951 49.47 µM 0.0464290910738485 0.483174334135995 no 1608 0.481484125092255 2260 16643986
SGTC_1215 3852-0577 11.2 µM 0.0461077701505731 0.483302102891772 no 1609 0.481612176456085 2312 2884876
SGTC_2593 nobiletin 86.24 µM 0.0447143243454626 0.48385620673439 no 1610 0.482167507970903 2273 72344 An anti-infammatory.
SGTC_57 miconazole 162.5 nM 0.0427608057494723 0.484633075824525 no 1611 0.482946103937286 2337 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1107 amlodipine 47 µM 0.0422610449743332 0.484831828595307 no 1612 0.483145299566104 2299 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2330 7979373 200 µM 0.0422464603542231 0.48483762889458 no 1613 0.483151112795982 2302 1863007
SGTC_3136 9095672 49.47 µM 0.0419078864899393 0.484972280523336 no 1614 0.483286064706542 2350 17217380
SGTC_1506 4226-2149 212 µM 0.0418878972416695 0.4849802303485 no 1615 0.483294032266499 2248 991114
SGTC_2790 5423970 71.43 µM 0.0418476654798372 0.484996230741813 no 1616 0.483310068356227 2312 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_136 0097-0015 404.482 µM 0.0415146680588097 0.48512866657567 no 1617 0.483442799757598 2338 4861337
SGTC_1360 1598-0022 39.8 µM 0.0412474990070306 0.485234923108287 no 1618 0.48354929356932 2311 761525
SGTC_2588 indole-3-carbinol 100 µM 0.0408368074670945 0.485398262403146 no 1619 0.483712997853053 2329 3712 Induces cell cycle arrest.
SGTC_198 3454-2873 16.191 µM 0.0395913282314155 0.485893626408264 no 1620 0.484209470544439 2304 710957
SGTC_342 k048-0088 23.3 µM 0.0392082678083277 0.486045985304105 no 1621 0.484362170974411 2344 6820570
SGTC_2421 5690543 90.72 µM 0.0385851964962629 0.486293810749821 no 1622 0.48461055249427 2274 3397993
SGTC_405 ebelactone b 50 µM 0.0380620214835468 0.486501906722241 no 1623 0.484819115909825 2259 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0375736934240893 0.486696145429368 no 1624 0.485013791356258 2325 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_364 0083-0097 67.7 µM 0.0367310790202847 0.487031313439031 no 1625 0.485349713941121 2297 5207356
SGTC_3184 9108758 49.47 µM 0.0359834043962739 0.487328724786334 no 1626 0.485647795878906 2322 902885
SGTC_2835 9006588 71.43 µM 0.0359320366893956 0.48734915818512 no 1627 0.485668275385177 2239 2345538
SGTC_2225 6654152 15.4 µM 0.0349357678535131 0.487745467339536 no 1628 0.486065479694548 2336 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_770 0389-1121 67.2 µM 0.0344036976364212 0.487957126335314 no 1629 0.486277617465689 2334 6753108
SGTC_211 3455-0679 143.504 µM 0.0330962504822855 0.488477246694679 no 1630 0.486798916397618 2265 748649
SGTC_3343 9148379 18.9835 µM 0.0313879151316876 0.489156875257475 no 1631 0.487480089365929 2353 1955036
SGTC_2872 9044037 25.97 µM 0.0311512765000083 0.489251019940945 no 1632 0.487574448378247 2286 6465195
SGTC_121 0557-0495 61.343 µM 0.0308871451798714 0.489356103065674 no 1633 0.487679770846742 2344 3104427
SGTC_655 k060-0012 42 µM 0.0276507690879091 0.490643734426314 no 1634 0.48897034462459 2340 5994525
SGTC_1259 0671-0132 43 µM 0.0273774324023296 0.490752489384797 no 1635 0.489079348917576 2326 X1259
SGTC_3355 9151058 44.0485 µM 0.0271036655755044 0.4908614161766 no 1636 0.489188525564782 2362 17015728
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0266506471341024 0.491041665386399 no 1637 0.489369188507741 2287 689007
SGTC_1896 st058441 89 µM 0.0239472146401962 0.492117357194658 no 1638 0.490447356615186 2308 688759
SGTC_273 hydroxyurea 18.1 mM 0.0237544955649142 0.492194042112385 no 1639 0.490524218537365 2370 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1843 st055809 45.5 µM 0.0223578724346349 0.492749781377577 no 1640 0.491081242435379 2315 16413835
SGTC_430 0958-0115 16.4 µM 0.0220760383878142 0.492861929511574 no 1641 0.491193650207066 2292 6833180
SGTC_1953 st076800 12.1 µM 0.0218631839333385 0.492946629481944 no 1642 0.491278546357745 2299 297591
SGTC_2477 5967686 25.23 µM 0.0216450728221755 0.493033421533859 no 1643 0.491365539514794 2353 776118
SGTC_2004 4023728 41.89 µM 0.0215798727549101 0.493059366391041 no 1644 0.491391544504145 2364 360084 YDR527W RBA50
SGTC_3305 9127027 53.8275 µM 0.0213674233800744 0.493143905904017 no 1645 0.491476280003287 2335 41905295
SGTC_2539 epi(13)torulosol 80 µM 0.0211075551939115 0.493247315098727 no 1646 0.491579929032691 2348 6708597
SGTC_2688 kanamycin b 96.69 µM 0.0209804611849491 0.493297889708748 no 1647 0.491630620980703 2353 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1160 4092-0570 10.5 µM 0.0208233871200006 0.493360394452679 no 1648 0.491693270779257 2356 4994975
SGTC_1633 st005664 67.9 µM 0.02078242510789 0.493376694561153 no 1649 0.491709608722183 2365 2063822
SGTC_1387 3342-1166 1.8 µM 0.0206902508386783 0.493413373722261 no 1650 0.491746373030227 2328 3418228
SGTC_2514 salinomycin 42.74 µM 0.0203369451831481 0.493553966129067 no 1651 0.491887291940389 2374 23682228 A polyether potassium ionophore.
SGTC_2258 7960471 200 µM 0.0196725967889223 0.493818335236792 no 1652 0.492152275571572 2301 2974708
SGTC_1649 st011737 51.3 µM 0.0194552532837057 0.493904824952695 no 1653 0.492238966493063 2347 1761035
SGTC_2278 7948257 134.34 µM 0.0185861092943658 0.494250695100796 no 1654 0.492585642050349 2381 1247028
SGTC_3088 9117578 49.47 µM 0.0181518054637026 0.49442352509641 no 1655 0.492758874981108 2374 678341
SGTC_1974 st069448 26.9 µM 0.0176818244691853 0.494610553897915 no 1656 0.492946340177353 2369 6323587 YNR016C ACC1
SGTC_2286 7945697 125 µM 0.0176782485012268 0.494611976957929 no 1657 0.492947766559216 2354 1245733
SGTC_559 1550-0661 158 µM 0.0169593009777152 0.494898084209604 no 1658 0.493234542106611 2351 5830875
SGTC_2471 5466956 24.79 µM 0.0164246570216977 0.49511084903178 no 1659 0.493447804471208 2314 724419
SGTC_255 tunicamycin 200.472 nM 0.0160443685246332 0.495262188007912 no 1660 0.493599497639125 2369 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2877 9040724 71.43 µM 0.0153564676405177 0.495535945613996 no 1661 0.493873896558934 2382 6463895
SGTC_1337 1486-1011 40.3 µM 0.014409578090455 0.495912773976248 no 1662 0.494251608986422 2384 X1337
SGTC_792 4534-1957 155 µM 0.0134052026516059 0.496312483655947 no 1663 0.494652258049793 2317 1717904
SGTC_1769 st044406 64.4 µM 0.0131539811265359 0.496412462477114 no 1664 0.494752472100986 2377 670903
SGTC_1734 st037168 69.4 µM 0.0130608623449518 0.496449521086931 no 1665 0.494789617928998 2328 708907
SGTC_32 0928-0142 34.1 µM 0.00914952153292762 0.498006146503415 no 1666 0.496349919942121 2394 2244242
SGTC_123 0083-0120 66.675 µM 0.00907343499389209 0.498036427607511 no 1667 0.496380272819545 2384 16001701
SGTC_2778 tioconazole 65.09 nM 0.00894437142974689 0.498087792661459 no 1668 0.49643175964272 2377 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_68 0986-0284 82.829 µM 0.00834040496882687 0.498328161216533 no 1669 0.496672698398132 2340 423278 YIL048W NEO1
SGTC_3300 9124615 50.48 µM 0.00706036152131782 0.498837599009078 no 1670 0.497183346675333 2383 24824903
SGTC_2413 inermin 26.06 µM 0.00692502319746066 0.498891461725568 no 1671 0.497237337534805 2383 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0065218234905218 0.499051929555935 no 1672 0.497398187308658 2393 551469
SGTC_1324 1418-0026 34.4 µM 0.00486708255566478 0.499710494573177 no 1673 0.498058322652246 2354 1372513
SGTC_2257 7960413 200 µM 0.00469016162063808 0.499780906844812 no 1674 0.498128903087559 2382 2974689 YIL048W NEO1
SGTC_2321 7390090 138.78 µM 0.00460643558640069 0.49981422873919 no 1675 0.498162304581727 2395 649046
SGTC_162 k030-0015 37.8 µM 0.00439467065525923 0.499898508487692 no 1676 0.498246785710522 2397 1809920 YMR134W ERG29
SGTC_1629 st005085 44.9 µM 0.00436901137779775 0.499908720554064 no 1677 0.498257022182912 2392 24207091
SGTC_2985 9022375 71.43 µM 0.0042529723820983 0.499954902600473 no 1678 0.49830331461428 2376 4939335
SGTC_3192 9110362 49.47 µM 0.00402634505444306 0.499954902600473 no 1679 0.498393725062307 2404 16649480
SGTC_80 0159-0065 512.242 µM 0.00345589548788879 0.499727870936166 no 1680 0.498621299917585 2397 1548079
SGTC_530 4358-1714 28 µM 0.00298462170033147 0.499540310032422 no 1681 0.498809309980506 2387 1564641
SGTC_318 1488-0629 67.2 µM 0.00268957993551122 0.499422887255304 no 1682 0.49892701414084 2394 3662576
SGTC_109 0132-0036 33.701 µM 0.00237025927768754 0.499295801851849 no 1683 0.49905440424403 2396 67274 A color developer.
SGTC_3205 9113483 49.47 µM 0.000890759747695368 0.498706981720124 no 1684 0.499644638321958 2402 17018033
SGTC_3002 9075603 71.4286 µM 0.000364552668534936 0.498497559270868 no 1685 0.49985456453031 2403 20105405
SGTC_1473 k844-0725 134 µM 0 0.49835247306845 no 1686 0.5 2405 54682906
SGTC_1909 st060837 51.5 µM 0 0.49835247306845 no 1687 0.5 2406 678937
SGTC_656 4090-1979 187 µM -0.000467407764822848 0.498166452484183 no 1688 0.499813531287214 2407 22330961
SGTC_795 0685-0265 78 µM -0.000781693225447573 0.498041372274131 no 1689 0.499688149553825 2407 302754
SGTC_1548 st061468 90.8 µM -0.00105661462074961 0.497931958442775 no 1690 0.499578471832127 2410 390799
SGTC_3128 9127691 49.47 µM -0.00133226881208256 0.497822253127804 no 1691 0.49946850179923 2409 41316314
SGTC_1386 3228-0095 33.8 µM -0.00159808816476875 0.497716462054207 no 1692 0.499362455334634 2405 870181
SGTC_105 0111-0055 734.78 µM -0.00306528070401003 0.49713255027081 no 1693 0.498777131840873 2432 5179370
SGTC_1634 st006576 41 µM -0.00326827440432536 0.497051763501419 no 1694 0.498696149477367 2414 3915356
SGTC_361 000s-0510 1.45 µM -0.00339113162991719 0.49700286924284 no 1695 0.498647136807357 2418 660
SGTC_49 0717-0965 32.132 µM -0.00429872920306847 0.496641668402583 no 1696 0.49828506045065 2446 5889349 YGL099W LSG1
SGTC_2974 9094440 9.66 µM -0.00445092812728272 0.496581097348189 no 1697 0.498224342445856 2439 25236134
SGTC_2555 cholic acid 100 µM -0.00598684470429304 0.49596984874953 no 1698 0.497611608788845 2461 6708657 Influences liver metabolism.
SGTC_3292 9120825 59.784 µM -0.00616849097638015 0.495897559594762 no 1699 0.497539143749302 2409 24824900
SGTC_3053 9095903 49.47 µM -0.0065175853193509 0.495758632075776 no 1700 0.497399878058395 2418 17174018
SGTC_554 4483-2211 187 µM -0.0065882889651147 0.495730494523249 no 1701 0.497371671990332 2427 747107
SGTC_1393 3470-5649 58.2 µM -0.00741863832219559 0.495400046448587 no 1702 0.497040418657644 2427 4108395
SGTC_2104 5389443 200 µM -0.00840535704270828 0.495007373321682 no 1703 0.496646787177936 2429 2244536
SGTC_840 0245-0196 390 µM -0.00863080794480186 0.494917653878333 no 1704 0.496556848544058 2449 3827528
SGTC_201 4262-0159 12.803 µM -0.00891092247188883 0.494806181099316 no 1705 0.496445103314469 2425 1341029
SGTC_330 1488-0319 80.1 µM -0.00906016679722752 0.494746788844162 no 1706 0.496385565846613 2442 6846614
SGTC_1217 1183-1422 255 µM -0.00955151968016715 0.494551254227506 no 1707 0.496189552896402 2435 2849664
SGTC_1709 st033179 39.1045 µM -0.00992758522938543 0.494401599260123 no 1708 0.496039531565097 2422 573381
SGTC_1257 0669-0121 16 µM -0.00993166797838566 0.494399974537896 no 1709 0.496037902864195 2431 4307855
SGTC_3186 9110464 49.47 µM -0.0120831901329542 0.493543793953978 no 1710 0.495179621872787 2440 17018021
SGTC_3014 9081533 49.47 µM -0.0121316719835723 0.493524501327246 no 1711 0.495160281830325 2434 21367265
SGTC_1880 MG-132 525 µM -0.0130159342885769 0.493172625082376 no 1712 0.494807540106813 2436 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3076 9116187 49.47 µM -0.0149516896470425 0.492402345053406 no 1713 0.494035361072693 2442 27241210
SGTC_1684 st024538 14.6195 µM -0.0162018552930816 0.491904891266532 no 1714 0.493536677674357 2441 6732859
SGTC_2595 hexamethylquercetagetin 100 µM -0.0168409428810251 0.491650596547184 no 1715 0.493281753412992 2456 386331
SGTC_750 4073-0104 132 µM -0.016871439454693 0.491638461960157 no 1716 0.493269588768649 2446 22330957
SGTC_1064 honokiol 6.76 µM -0.017136345543919 0.491533056150848 no 1717 0.493163921806603 2449 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2364 9055074 200 µM -0.0179381803517441 0.491214010693829 no 1718 0.492844085195982 2452 6470630
SGTC_445 e6 berbamine 66 µM -0.0189307217379413 0.490819091994048 no 1719 0.492448185762994 2464 6610268 A calcium/calmodulin antagonist.
SGTC_2784 7567673 72.73 µM -0.0189425455818479 0.490814387501066 no 1720 0.492443469577421 2433 3471247
SGTC_2657 nystatin 74.44 µM -0.0203969890880504 0.490235700765509 no 1721 0.491863342855762 2458 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2407 paclitaxel 400 µM -0.020520524540612 0.49018655002501 no 1722 0.491814069653631 2605 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_947 3447-0010 211 µM -0.0206431014334438 0.490137780811549 no 1723 0.491765178904937 2433 748350
SGTC_592 k241-0073 46.5 µM -0.0209186084011177 0.490028166415974 no 1724 0.491655291257053 2445 4230158
SGTC_664 1222-0054 14.9 µM -0.0209328121438863 0.490022515273693 no 1725 0.49164962602402 2454 6813991
SGTC_420 mitomycin C 81.9 mM -0.0214652131558191 0.489810694117913 no 1726 0.491437276472846 2450 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3221 9128209 49.47 µM -0.0216741521510034 0.489727566396181 no 1727 0.491353941261953 2462 16460723
SGTC_682 0kpi-0099 17 µM -0.0220871142011956 0.48956326810705 no 1728 0.491189232673935 2483 1714895 YML126C ERG13
SGTC_2563 tomatine 8.54 µM -0.0233648143583721 0.489054942300647 no 1729 0.490679635706843 2433 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1355 1499-0035 1.68 µM -0.0242753173096109 0.488692714633272 no 1730 0.490316500630929 2449 1548538
SGTC_523 1934-0222 13.7 µM -0.0246221260721047 0.488554745272095 no 1731 0.49017818529753 2462 1361595
SGTC_3193 9111931 49.47 µM -0.0248847114476658 0.488450283030159 no 1732 0.490073460978177 2472 17087244
SGTC_2361 9034121 116 µM -0.0250858883746352 0.488370250956361 no 1733 0.489993228043527 2468 6496917
SGTC_2964 9083345 53.42 µM -0.025342932731396 0.488267994419963 no 1734 0.48989071477439 2472 17741579
SGTC_1733 st037357 54.9 µM -0.0260507757044149 0.487986406674474 no 1735 0.489608419509625 2460 1272339 YGL099W LSG1
SGTC_130 0136-0219 337.655 µM -0.0262357512641522 0.487912822336949 no 1736 0.489534650151998 2452 234244
SGTC_1979 st071809 45.3 µM -0.026524562058001 0.487797932572049 no 1737 0.489419471399845 2535 4976333
SGTC_2048 5246248 200 µM -0.0268526790130317 0.487667407932353 no 1738 0.489288618284643 2473 677046
SGTC_2961 9083290 32.55 µM -0.0277954540436447 0.487292380243224 no 1739 0.488912645855518 2449 17741490
SGTC_3058 9093861 49.47 µM -0.0286012182878051 0.486971863144043 no 1740 0.488591320214999 2469 17217477
SGTC_1333 1482-0047 286 µM -0.028950892964411 0.4868327720714 no 1741 0.488451877948157 2461 3811116
SGTC_251 melphalan 456.522 µM -0.0291701975848128 0.486745539476299 no 1742 0.48836442499844 2475 460612 A DNA alkylator.
SGTC_1699 st031318 29.054 µM -0.0296030509619285 0.486573365655785 no 1743 0.488191816032815 2514 5340658
SGTC_210 3551-0445 56.827 µM -0.0305848871713373 0.486182835136569 no 1744 0.48780029740115 2488 2865180 YOR207C RET1
SGTC_1046 2001-0062 216 µM -0.0309146796375073 0.486051661401961 no 1745 0.487668791430613 2471 739778
SGTC_2953 9074162 66.49 µM -0.0311041729202446 0.485976291830857 no 1746 0.487593230886049 2472 16451992
SGTC_218 alverine citrate 93.75 µM -0.0328672265695774 0.485275074470514 no 1747 0.486890234038472 2516 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1781 st038725 66.3 µM -0.0334786743198132 0.485031894562536 no 1748 0.486646435862551 2472 4270275 YIL048W NEO1
SGTC_2263 7948595 193.29 µM -0.0343751030587338 0.484675384477143 no 1749 0.486289018308231 2469 2971371
SGTC_1066 ketoconazole 628 nM -0.0351545750656262 0.484365398079703 no 1750 0.485978241834207 2483 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2151 5563267 85.4165 µM -0.0352140050072682 0.484341763910667 no 1751 0.48595454738839 2485 5310824
SGTC_2987 9018338 71.43 µM -0.0360086325384142 0.484025760818237 no 1752 0.48563773782464 2451 5055682
SGTC_1405 3909-7894 12 µM -0.0372373758039397 0.483537140798835 no 1753 0.485147868842262 2499 7104060
SGTC_2107 5363541 170.161 µM -0.0375021981981841 0.483431835175788 no 1754 0.485042293736322 2467 244052
SGTC_3015 9080845 49.47 µM -0.0378324613784397 0.483300508892037 no 1755 0.484910631227004 2512 5296973
SGTC_2014 4013930 200 µM -0.0379196585669945 0.483265835989452 no 1756 0.484875869525211 2466 64556
SGTC_2512 diallyl trisulfide 49.23 µM -0.0381324477616183 0.483181223483359 no 1757 0.484791040271732 2459 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_360 0957-0399 1.01 µM -0.0394564714669087 0.482654762020749 no 1758 0.484263228604384 2503 6752301 YPR165W RHO1
SGTC_622 1348-1566 26.3 µM -0.0395957039667526 0.482599401803635 no 1759 0.484207726246362 2518 7340407
SGTC_2124 5246320 200 µM -0.0398531419092787 0.482497042819456 no 1760 0.484105104368933 2529 579342
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0401703209189915 0.482370931989239 no 1761 0.483978669499784 2501 23847180
SGTC_765 1319-0117 244 µM -0.0407531508085888 0.482139202595046 no 1762 0.48374634427155 2486 3487746 YGL099W LSG1
SGTC_317 4495-0002 170 µM -0.0410910682826027 0.482004851551549 no 1763 0.483611647534611 2513 15991618
SGTC_1768 st044301 37.178 µM -0.041369040971888 0.481894335208699 no 1764 0.483500846692589 2502 3931349
SGTC_736 0958-0254 92.6 µM -0.0423589770763547 0.481500767910375 no 1765 0.483106265264031 2527 6812352
SGTC_2097 5376186 200 µM -0.0429841073320154 0.481252245147309 no 1766 0.482857101328024 2482 742755
SGTC_564 3555-0129 330 µM -0.0432973709895614 0.481127708797157 no 1767 0.482732243452658 2480 563260
SGTC_2167 5876490 200 µM -0.0440359019868012 0.480834116922196 no 1768 0.482437892983052 2643 686534
SGTC_2488 5268135 45.7 µM -0.0446722400922715 0.480581158623777 no 1769 0.482184280399096 2517 1270356 YLR208W SEC13
SGTC_676 falcarinol 140 µM -0.0454121628030382 0.480287033021081 no 1770 0.481889393237558 2482 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_191 3914-0123 66.505 µM -0.0455763716613241 0.480221760045738 no 1771 0.481823951139981 2485 3144412
SGTC_746 1095-0025 46.6 µM -0.0455816720151537 0.480219653165395 no 1772 0.481821838800015 2494 6749286
SGTC_549 1661-1316 519 µM -0.0460775540872609 0.480022543458071 no 1773 0.481624218123028 2495 2857282
SGTC_764 1951-2361 146 µM -0.0463122157838409 0.479929268750179 no 1774 0.481530701484865 2493 5438930
SGTC_1028 k015-0029 4.8 µM -0.0489657229173144 0.478874614862304 no 1775 0.480473306153095 2503 4588309
SGTC_2376 9072922 81.32 µM -0.049039912359346 0.478845129870916 no 1776 0.480443744362244 2600 17087968
SGTC_1844 rapamycin 4 nM -0.0494395465762986 0.478686305878217 no 1777 0.480284506534634 2486 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1268 0828-0275 2.46 µM -0.0500852264499974 0.478429704744359 no 1778 0.4800272362737 2563 745337
SGTC_3211 9128781 49.47 µM -0.0504079173785473 0.478301466739335 no 1779 0.479898663626681 2608 17194361
SGTC_1727 st034309 9.9045 µM -0.0507926452125534 0.47814857808383 no 1780 0.47974537579206 2587 870305
SGTC_2303 7774051 200 µM -0.0514944759723919 0.477869682826618 no 1781 0.479465751774456 2543 2953184
SGTC_1063 disulfiram 1.84 µM -0.0519010150232265 0.477708136273212 no 1782 0.479303782748059 2498 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1445 4239-0156 97.7 µM -0.052502706747323 0.477469048569306 no 1783 0.479064069319425 2595 4008346
SGTC_95 0471-0001 561.058 µM -0.0525654902071506 0.477444101453676 no 1784 0.479039056881676 2509 4015405
SGTC_3289 9119912 71.43 µM -0.0530083138386863 0.477268147238787 no 1785 0.478862641771594 2545 17014829
SGTC_2734 clemastine 41.6 µM -0.0542857315544978 0.476760595322735 no 1786 0.478353758680248 2501 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1943 st076331 65.2 µM -0.0545058593655437 0.476673136493915 no 1787 0.478266070216329 2501 24208415
SGTC_1184 1269-1718 139 µM -0.0552164017516996 0.476390839076881 no 1788 0.477983031080691 2554 5403821
SGTC_1204 4049-0315 18.3 µM -0.0552795234744297 0.476365761482734 no 1789 0.477957887559238 2741 588402
SGTC_641 4092-0595 30 µM -0.0554539707969426 0.476296455890042 no 1790 0.477888399734991 2536 786260
SGTC_490 phenamil 164 µM -0.0556408926387012 0.476222195133216 no 1791 0.477813943665683 2541 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_561 1550-0330 72.9 µM -0.0558519360386601 0.4761383522987 no 1792 0.477729880252497 2519 6812934
SGTC_897 1000-0139 31.4 µM -0.0560902296712469 0.476043684824751 no 1793 0.477634963639618 2497 6151020
SGTC_1841 st054148 70 µM -0.0569379752040986 0.475706909954684 no 1794 0.477297301764052 2557 675442
SGTC_1323 1348-1351 11.2 µM -0.0569647958936852 0.475696255465938 no 1795 0.477286619195286 2513 6989654
SGTC_756 0508-1999 28.3 µM -0.0581099244201857 0.47524137075652 no 1796 0.476830534604537 2518 6753853
SGTC_1702 st027038 51 µM -0.0582183158415554 0.475198315592631 no 1797 0.476787365767023 2553 5521182
SGTC_3331 9141060 1.957 µM -0.0586670140851523 0.475020087079584 no 1798 0.476608666506434 2523 4906567 YPR165W RHO1
SGTC_693 4161-2696 114 µM -0.0595692688263253 0.47466171546241 no 1799 0.476249347405577 2580 805759
SGTC_1994 st072947 40.9 µM -0.0603167275678327 0.474364843649946 no 1800 0.47595168976453 2636 5286565 YDL195W SEC31
SGTC_1349 flufenamic acid 69 µM -0.0605388252604266 0.474276634768209 no 1801 0.47586324722693 2513 3371 A non-steroidal anti-inflammatory.
SGTC_156 3474-0145 5.642 µM -0.061226729661856 0.474003432935855 no 1802 0.475589321234928 2493 2265471
SGTC_2040 5100729 123 µM -0.0613630217640619 0.473949305855732 no 1803 0.475535050597801 2521 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2677 mitomycin C 100 µM -0.0615226664737749 0.473885905126765 no 1804 0.475471481680066 2524 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1235 benzylparaben 21.5 µM -0.0616607867244462 0.473831053078081 no 1805 0.475416484089135 2558 7180
SGTC_3196 9111891 49.47 µM -0.0620569319583175 0.473673733663042 no 1806 0.475258747087856 2490 18891510
SGTC_2444 5485484 36.41 µM -0.0625551202404982 0.473475896172114 no 1807 0.475060384121029 2577 6790631
SGTC_653 0203-0016 55.2 µM -0.0641237899978342 0.472852998566626 no 1808 0.474435829573135 2575 295302
SGTC_3013 9080133 71.4286 µM -0.0643752733610472 0.472753144048928 no 1809 0.474335709089199 2606 17050193
SGTC_1452 4194-0072 190 µM -0.0648586261540331 0.472561227777159 no 1810 0.474143281371779 2540 1343545
SGTC_171 k064-0041 9.68 µM -0.0657030728148273 0.472225953716018 no 1811 0.473807112974727 2529 53325
SGTC_1219 1469-0211 33.1 µM -0.0666896547894166 0.471834272041226 no 1812 0.473414385129762 2518 6822282
SGTC_1993 st073995 70.8 µM -0.0678972736343657 0.471354873909556 no 1813 0.472933704535592 2568 3098394
SGTC_2459 5811157 9.22 µM -0.0680260953648007 0.471303736952379 no 1814 0.472882430649228 2517 2870684 YBR192W RIM2
SGTC_1632 st005650 90 µM -0.0680764238521049 0.471283758730224 no 1815 0.472862398924675 2598 2759605
SGTC_9 0092-0002 10.449 µM -0.0683167951225845 0.47118834278015 no 1816 0.472766727394488 2532 759368
SGTC_2744 captopril 92.04 µM -0.0701705291422001 0.470452554600498 no 1817 0.47202896541263 2540 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_308 4092-1169 104 µM -0.0702593141571411 0.470417316368527 no 1818 0.47199363252172 2534 2268590 YDL196W YDL196W
SGTC_322 k048-0136 19.3 µM -0.0704394134972214 0.470345836748603 no 1819 0.471921960852726 2617 6823282
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0714440787207643 0.469947112804007 no 1820 0.471522164734241 2541 5106787 A p450 inhibitor.
SGTC_2248 tofa 1.1 µM -0.071746618966307 0.469827048801668 no 1821 0.471401777580852 2528 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2424 5537928 59.2 µM -0.0735129697004409 0.469126122337371 no 1822 0.470698961835988 2555 5382802
SGTC_2871 9038510 12.99 µM -0.0735246911710287 0.469121471319562 no 1823 0.470694298266168 2537 4945164
SGTC_1778 st046819 58.9 µM -0.0743939168401537 0.468776578936464 no 1824 0.47034847452523 2542 671715
SGTC_2223 6903751 107.57 µM -0.0760761037295913 0.468109185620607 no 1825 0.469679275747954 2639 5598863
SGTC_1604 st002052 72.4 µM -0.0761921488047659 0.468063149008836 no 1826 0.469633114439938 2666 6254834 YHR062C RPP1
SGTC_392 N-ethylmaleimide 8.33 µM -0.0762602364135671 0.468036137955233 no 1827 0.469606030213964 2567 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1377 2944-0135 198 µM -0.0769168005670443 0.467775679782913 no 1828 0.469344866110727 2593 1894137
SGTC_1369 1866-0067 208 µM -0.077909896129891 0.467381746273244 no 1829 0.468949863683953 2526 3531355
SGTC_458 nppb 133 µM -0.0781299099163955 0.467294477205559 no 1830 0.468862357617445 2577 4549 A chloride channel blocker.
SGTC_979 1426-2828 121 µM -0.0790032335889341 0.466948086537577 no 1831 0.468515025536414 2635 747872
SGTC_2802 7925815 54.55 µM -0.0790765073292848 0.466919024747716 no 1832 0.468485884711421 2569 1262923
SGTC_398 bronopol 33.3 µM -0.081062125879043 0.466131557483863 no 1833 0.467696272848168 2563 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2715 st079500 56.4 µM -0.082865266688965 0.465416572998908 no 1834 0.466979336095099 2544 28246688
SGTC_909 3448-9333 149 µM -0.0832169468695309 0.465277137107466 no 1835 0.466839518912089 2552 3344074
SGTC_228 caffeine 993.056 µM -0.0834260033773215 0.465194251372066 no 1836 0.46675640643646 2577 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_954 1189-0853 2.85 µM -0.0836354040258904 0.465111230707142 no 1837 0.466673158597386 2528 2828194
SGTC_344 k064-0035 6.43 µM -0.0836427769133335 0.465108307620556 no 1838 0.46667022751101 2559 5088750
SGTC_2832 7992762 51.95 µM -0.0860481994364853 0.464154744906236 no 1839 0.465714050837002 2564 2985177
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0862613446626044 0.46407025927099 no 1840 0.465629333193254 2582 6708514
SGTC_823 0417-1665 178 µM -0.0865924060882674 0.463939037707425 no 1841 0.465497751145538 2636 3429856
SGTC_1313 1220-0047 237 µM -0.0903534860081703 0.462448551568514 no 1842 0.464003159115766 2606 3528706
SGTC_1640 st009078 66.4 µM -0.0920987570642679 0.461757092272397 no 1843 0.463309787987896 2613 690618
SGTC_346 4513-0042 7.16 µM -0.0921604622132268 0.461732647399938 no 1844 0.463285275445696 2586 2827372
SGTC_2090 5301565 104.445 µM -0.0928949204982891 0.461441698380961 no 1845 0.462993520577264 2590 2056344
SGTC_2084 5306078 60.6385 µM -0.0952685921061027 0.460501531703572 no 1846 0.462050744513165 2636 679340
SGTC_3143 9086658 49.47 µM -0.0955016738038176 0.460409224245429 no 1847 0.46195818041767 2660 25236626
SGTC_3239 9133757 49.47 µM -0.096381511619354 0.460060800915755 no 1848 0.461608787673762 2571 17036923
SGTC_2150 5556613 200 µM -0.0965788724171355 0.459982648546789 no 1849 0.461530417707863 2610 743190
SGTC_1200 1643-0193 18.4 µM -0.0971624225161194 0.459751579175388 no 1850 0.461298704647119 2549 5403974
SGTC_131 0141-0277 33.849 µM -0.0976606078552394 0.459554322593387 no 1851 0.461100898176893 2681 1547771
SGTC_1036 k216-0215 33.5 µM -0.098036552725276 0.459405473737543 no 1852 0.460951634139755 2573 622330
SGTC_1729 st035615 45.989 µM -0.0983071636671676 0.459298333545929 no 1853 0.460844194977217 2730 17385451
SGTC_1510 1123-0200 71.5 µM -0.0983312155441699 0.459288811077936 no 1854 0.460834645931977 2751 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2186 6124449 200 µM -0.0984557894420188 0.459239490937056 no 1855 0.460785188124973 2655 3834182 YLR033W RSC58
SGTC_3023 9089636 49.47 µM -0.0986841619217207 0.459149077455195 no 1856 0.46069452221575 2559 17249241
SGTC_2777 climbazole 1.536 µM -0.0986881287465401 0.459147506993711 no 1857 0.460692947368993 2581 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_730 1436-0052 41.2 µM -0.0994702560337063 0.458837876166354 no 1858 0.460382451499978 2578 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1443 4112-3303 14 µM -0.099488484752117 0.458830660025287 no 1859 0.460375215188014 2582 704433
SGTC_406 estrone 100 µM -0.100118156908846 0.45858140218369 no 1860 0.460125260314204 2614 5870 A steroid.
SGTC_1693 xanthone 101.9 µM -0.10239008109575 0.457682189431994 no 1861 0.459223528216753 2631 7020 An insecticide.
SGTC_390 dec-rvkr-cmk 16.7 µM -0.103031338571204 0.457428422904573 no 1862 0.458969049358987 2649 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3071 9117417 49.47 µM -0.104240311980437 0.456950039927929 no 1863 0.458489321937469 2674 45595590 YGL055W OLE1
SGTC_2006 4011487 200 µM -0.104520720610918 0.456839092928944 no 1864 0.458378062833478 2672 45595294
SGTC_1240 0356-0016 42.1 µM -0.104566902986807 0.456820820646857 no 1865 0.4583597391388 2663 4305613
SGTC_2147 5545932 89.7195 µM -0.104813725960866 0.456723165483056 no 1866 0.45826180915143 2617 797404
SGTC_1000 4048-0884 8.67 µM -0.105025289194238 0.456639462866223 no 1867 0.458177870907011 2706 13040088
SGTC_3222 9128301 49.47 µM -0.106266022510303 0.456148619512577 no 1868 0.457685644509206 2628 4911358
SGTC_294 k038-0071 157 µM -0.106388456788738 0.456100187213935 no 1869 0.457637075623762 2646 24152826
SGTC_933 2914-0560 114 µM -0.108190107940717 0.455387569574468 no 1870 0.456922445808219 2638 463887
SGTC_2795 7780010 54.55 µM -0.108426324611448 0.455294148003153 no 1871 0.456828760103824 2705 953673
SGTC_2095 5432005 200 µM -0.108487160778063 0.455270088245883 no 1872 0.456804632308909 2638 783734
SGTC_1241 0364-0022 50.8 µM -0.108942645901699 0.455089956185532 no 1873 0.456623990692265 2682 4563895
SGTC_1261 0712-0010 12.7 µM -0.109226341868743 0.45497776675949 no 1874 0.45651148375591 2656 2840123
SGTC_745 0469-0705 296 µM -0.110431619457485 0.454501171994195 no 1875 0.456033538887399 2671 3486736
SGTC_47 0149-0135 24.25 µM -0.110710772517349 0.454390797703996 no 1876 0.455922851632416 2560 5239155
SGTC_1437 4092-1038 11.6 µM -0.113716650933311 0.453202528716102 no 1877 0.45473120630541 2613 3977136
SGTC_2024 5144227 134 µM -0.113724181454169 0.45319955230945 no 1878 0.454728221425513 2718 3475211
SGTC_1814 st052110 31.539 µM -0.113763215229179 0.45318412441642 no 1879 0.454712749611008 2641 674163
SGTC_1392 3455-1037 33.9 µM -0.114012596337198 0.453085559521882 no 1880 0.454613904062347 2738 981132
SGTC_3050 9093513 49.47 µM -0.114927282229731 0.452724065671474 no 1881 0.454251380138702 2625 25236664
SGTC_2884 9058502 51.95 µM -0.11553718981683 0.452483045288575 no 1882 0.454009672312616 2689 6471554
SGTC_379 3970-0972 5.9 µM -0.116121307536122 0.452252232834896 no 1883 0.453778201038024 2668 2898042 YBL034C STU1
SGTC_2354 9060492 162 µM -0.117574271511756 0.451678168410314 no 1884 0.453202495939854 2712 6471895
SGTC_3095 9117207 49.47 µM -0.118019182878088 0.451502404581374 no 1885 0.453026229183314 2661 17015229
SGTC_1686 st019653 115.5 µM -0.118285438340836 0.451397223951932 no 1886 0.452920747458457 2605 97252
SGTC_2638 epoxomicin 18 µM -0.11929289522374 0.450999272640462 no 1887 0.452521656048292 2720 9915668 A protesome inhibitor.
SGTC_3033 9090887 49.47 µM -0.119359696763219 0.450972887381562 no 1888 0.452495195147265 2633 19325384
SGTC_2886 9058944 51.95 µM -0.119584834875374 0.450883963970455 no 1889 0.452406016761404 2595 4949929
SGTC_2121 5257820 149.641 µM -0.119932426014322 0.450746679797499 no 1890 0.452268338806471 2687 791256
SGTC_3285 9112818 20.8695 µM -0.12001635894239 0.450713530632989 no 1891 0.45223509453241 2603 17017947 YPR165W RHO1
SGTC_2307 7538926 6.34 µM -0.120066487863183 0.450693732466545 no 1892 0.452215239557559 2682 96582
SGTC_2074 5212007 75.395 µM -0.122171510500882 0.449862475648742 no 1893 0.451381594368377 2621 758611
SGTC_457 grayanotoxin iii 135 µM -0.122290970150884 0.449815308537027 no 1894 0.45133429154968 2691 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3288 9119690 36.221 µM -0.122330762459696 0.449799597211282 no 1895 0.451318535015616 2658 17595618 YKL019W RAM2
SGTC_3000 9075062 71.4286 µM -0.123703761570199 0.449257539905852 no 1896 0.450774916618956 2650 17057871
SGTC_762 1165-0429 115 µM -0.123746635769746 0.449240614776825 no 1897 0.450757942704189 2696 5967793
SGTC_2787 5284540 71.43 µM -0.123877657032561 0.449188893059419 no 1898 0.450706071885906 2696 736958
SGTC_1623 st003709 20.3 µM -0.125003429484986 0.448744520826578 no 1899 0.450260417650774 2617 16192618
SGTC_2207 7258803 200 µM -0.125300999643194 0.44862707271647 no 1900 0.450142630410575 2682 3666799
SGTC_2840 9008771 71.43 µM -0.126232694591969 0.448259370747542 no 1901 0.449773865908623 2789 2992978
SGTC_2966 9084041 48.03 µM -0.126597186321 0.448115532817199 no 1902 0.449629612006998 2601 17741380
SGTC_3257 9139206 32.98 µM -0.127421144882344 0.447790402474858 no 1903 0.449303540724999 2731 4910041
SGTC_265 mycophenolic acid 32.932 µM -0.127962496027027 0.447576806826699 no 1904 0.449089326409424 2868 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_403 arphamenine a 50 µM -0.1312710093871 0.446271731552498 no 1905 0.447780462233756 2630 5487158 An arginine aminopeptidase inhibitor.
SGTC_912 3474-0017 2.18 µM -0.131705788571915 0.446100271622256 no 1906 0.447608503394657 2783 3360550
SGTC_3085 9117376 49.47 µM -0.132014198577807 0.445978652869004 no 1907 0.447486530600685 2718 16480349
SGTC_1061 3448-9325 110 µM -0.133256780270656 0.445488703392658 no 1908 0.44699515351828 2604 723482
SGTC_1643 st009866 20.2 µM -0.134286889300811 0.445082594879222 no 1909 0.446587860081065 2672 3156273 YOR207C RET1
SGTC_285 1486-1325 46 µM -0.13471291162344 0.444914657350537 no 1910 0.446419432125795 2735 22310230
SGTC_3157 9099274 49.47 µM -0.134954348760054 0.444819487485327 no 1911 0.446323984226087 2671 17217662
SGTC_2057 5236571 38.335 µM -0.134965502884998 0.444815090821111 no 1912 0.446319574715278 2724 54684039 YBR257W POP4
SGTC_883 0850-0245 24.6 µM -0.135578528477079 0.444573462626857 no 1913 0.446077240246025 2846 6823229 YPR165W RHO1
SGTC_491 tetrandrine 80.3 µM -0.136491407493794 0.444213683369543 no 1914 0.445716408404643 2738 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1414 3917-0015 5.4 µM -0.136555916958878 0.444188260961089 no 1915 0.445690911576192 2658 6618702
SGTC_1199 1638-0010 4.46 µM -0.137415344977292 0.44384959260941 no 1916 0.445351251283785 2646 3111136
SGTC_3097 9117246 49.47 µM -0.137936197408984 0.443644364137765 no 1917 0.445145421217412 2632 16423892
SGTC_3246 9135460 32.98 µM -0.138902350331563 0.443263716549477 no 1918 0.444763656839104 2645 41446951
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.138915378679194 0.443258583962158 no 1919 0.444758509184465 2754 1273210
SGTC_2989 9073649 71.4286 µM -0.139047250841803 0.443206632753515 no 1920 0.444706405453834 2627 21367202
SGTC_1899 st063254 59.6 µM -0.139142646996126 0.443169051923914 no 1921 0.44466871427701 2639 3093813
SGTC_3109 9122853 49.47 µM -0.139623040526058 0.442979811113115 no 1922 0.444478917616577 2713 1234709
SGTC_1454 4239-0054 42.6 µM -0.140929662559024 0.442465161083337 no 1923 0.443962754333887 2831 1340767
SGTC_1466 k213-0079 57.5 µM -0.142072346407063 0.442015162284223 no 1924 0.443511430474535 2630 3657981
SGTC_1939 st074455 53.6 µM -0.14239649057349 0.441887525100256 no 1925 0.443383417128736 2870 1644229
SGTC_867 0518-0118 155 µM -0.144858068732892 0.440918435373787 no 1926 0.44241146672981 2682 6848158
SGTC_2100 5377183 190 µM -0.14545017528828 0.440685383655086 no 1927 0.442177725837548 2744 2844202
SGTC_1039 k821-0043 94 µM -0.146685057191452 0.440199403292673 no 1928 0.441690306824341 2722 15992768
SGTC_2345 9052315 157.45 µM -0.146882520917675 0.440121700962613 no 1929 0.441612374280683 2769 6469265
SGTC_910 3454-3003 490 µM -0.14722821992454 0.43998567333842 no 1930 0.441475943512243 2682 820824
SGTC_1175 0741-0056 27.6 µM -0.147256775096064 0.439974437602578 no 1931 0.441464674469915 2836 765927
SGTC_2772 vinpocetine 57.06 µM -0.148461780711668 0.439500342625565 no 1932 0.440989173115325 2819 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2283 7944793 200 µM -0.148596063220859 0.439447516146439 no 1933 0.440936189808206 2716 2970533
SGTC_292 k038-0015 474 µM -0.149427835981359 0.439120322413609 no 1934 0.440608024182564 2791 46368540
SGTC_3155 9099265 49.47 µM -0.149630743200093 0.439040511278209 no 1935 0.440527975835943 2777 25236499
SGTC_944 3370-0224 231 µM -0.150206350014789 0.438814116697673 no 1936 0.440300908074335 2711 4580514
SGTC_1493 4348-0038 111 µM -0.150400952729254 0.438737581127215 no 1937 0.440224144825867 2677 800424
SGTC_2022 5136654 200 µM -0.151114049551509 0.43845714589031 no 1938 0.43994287491624 2820 1713771
SGTC_3332 9141069 11.198 µM -0.153794732550998 0.437403207568573 no 1939 0.438885793619898 2676 17332883
SGTC_174 3553-0389 74.3 µM -0.154038453366838 0.437307408109596 no 1940 0.438789707998992 2802 738071
SGTC_3054 9094397 49.47 µM -0.154429611643779 0.437153663021961 no 1941 0.438635503494823 2718 2598354
SGTC_851 0394-0702 453 µM -0.154749398483881 0.437027977587003 no 1942 0.438509442338827 2683 762646
SGTC_3237 9133362 49.47 µM -0.15633737681558 0.43640395076624 no 1943 0.437883548050574 2748 43845137
SGTC_3035 9091303 49.47 µM -0.156541453089901 0.436323766487099 no 1944 0.437803123568156 2682 25237002
SGTC_2259 7964009 200 µM -0.157850842720837 0.435809352302605 no 1945 0.437287167068107 2865 313134
SGTC_2705 st078069 42.8 µM -0.159086071723129 0.435324172793747 no 1946 0.436800530811489 2759 1530061
SGTC_1525 8-methoxypsoralen 92.5 µM -0.161210804087462 0.434489837781521 no 1947 0.435963685994332 2902 4114 Related to psoralen; DNA damaging agent.
SGTC_180 1486-1293 102.781 µM -0.161699111510401 0.434298131433432 no 1948 0.435771402122746 2722 4140536
SGTC_1810 st050138 53 µM -0.1622288406577 0.434090180655635 no 1949 0.435562824529114 2695 3444541
SGTC_1990 st072050 59.8 µM -0.162338514763424 0.434047129202846 no 1950 0.435519643262265 2647 17233948
SGTC_83 0170-0301 39.027 µM -0.163463796134331 0.433605456744485 no 1951 0.435076638104384 2684 3089716
SGTC_2720 fluspirilene 36.88 µM -0.164568954645452 0.433171763180378 no 1952 0.434641634296756 2791 3396 An atypical antipsychotic.
SGTC_2854 9024559 71.43 µM -0.168004726826284 0.431823991126348 no 1953 0.433289780233841 2793 3163529
SGTC_2162 5663267 200 µM -0.168716167148008 0.431545008545521 no 1954 0.433009950768979 2740 6456493
SGTC_2285 7945142 200 µM -0.169087084221577 0.431399571504296 no 1955 0.432864071975117 2828 2970608
SGTC_1007 4101-0031 70 µM -0.169371311784533 0.431288131819379 no 1956 0.432752293680388 2870 1146276
SGTC_972 1319-0219 195 µM -0.171493870427981 0.430456094477217 no 1957 0.43191772486919 2777 23903702
SGTC_2199 6590217 200 µM -0.172468340278229 0.430074208043835 no 1958 0.431534674589978 2760 703109
SGTC_2757 clomiphene 4.22 µM -0.173104623682035 0.429824889270666 no 1959 0.431284595323427 2871 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1232 0279-0259 161 µM -0.173605455294739 0.429628665067432 no 1960 0.431087772211967 2723 1560000
SGTC_2130 NSC 7 2.4545 µM -0.174623066084741 0.429230022050681 no 1961 0.430687911473371 2824 21448
SGTC_1186 1319-0216 26 µM -0.174674571988598 0.429209846832419 no 1962 0.430667674590974 2889 4565136
SGTC_1929 genistein trimethyl ether 50.5 µM -0.175904064542806 0.428728301118138 no 1963 0.430184656050552 2781 136420
SGTC_2343 7990716 14.84 µM -0.176098437255442 0.42865218237323 no 1964 0.430108304315209 2742 6456862
SGTC_169 k015-0017 16.025 µM -0.176584674147942 0.428461777655151 no 1965 0.429917316577906 2839 1840002
SGTC_1211 1056-0033 32.3 µM -0.177632458906764 0.428051533973681 no 1966 0.429505815696807 2730 6741922
SGTC_609 0986-0026 86.3 µM -0.179282430368757 0.427405671330188 no 1967 0.428857970937822 2735 2848610
SGTC_2185 6113692 200 µM -0.181196834599481 0.426656543343153 no 1968 0.42810653955127 2848 874150
SGTC_1562 morin hydrate 59.1 µM -0.181589227321203 0.426503028215783 no 1969 0.427952551821232 2904 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_534 k292-0788 63.4 µM -0.1840657827902 0.425534387514457 no 1970 0.42698092459247 2733 4146317
SGTC_482 fipronil 114 µM -0.18488774231626 0.425212998286138 no 1971 0.426658542728093 2709 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2794 7785382 27.27 µM -0.184969134714509 0.425181176256605 no 1972 0.426626622367034 2726 2205081
SGTC_1161 k007-0610 110 µM -0.187394868213045 0.424233010571365 no 1973 0.42567552295381 2816 5843850
SGTC_260 nsc-65238 3.989 µM -0.187525659238776 0.424181899652081 no 1974 0.425624253680243 2858 3246252
SGTC_813 k007-0158 173 µM -0.187899496223774 0.424035817519185 no 1975 0.425477718829578 2828 6523916
SGTC_807 1315-0151 48 µM -0.188958456916971 0.423622070247673 no 1976 0.425062688371652 2921 4011080
SGTC_1978 st071761 42 µM -0.18928338256918 0.42349513517832 no 1977 0.42493535934527 2764 5147680
SGTC_2824 7998404 51.95 µM -0.189347299220863 0.423470166509164 no 1978 0.424910313167431 2732 837851
SGTC_1755 st041960 45.185 µM -0.189684521805478 0.42333843755305 no 1979 0.424778175208151 2870 2257073
SGTC_1469 k284-2957 126 µM -0.190140349264128 0.423160391703003 no 1980 0.424599576318829 2771 23884841
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.190912751573787 0.422858727803802 no 1981 0.424296974806109 2903 6728940
SGTC_1583 clindamycin 39.6 µM -0.19117124421044 0.422757782868064 no 1982 0.424195715951988 2737 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3313 9133968 57.047 µM -0.191836238330016 0.422498116825754 no 1983 0.423935242015202 2722 1494643
SGTC_961 1252-1571 372 µM -0.192382956095672 0.422284660400522 no 1984 0.4237211210512 2890 6813498
SGTC_2881 9058953 51.95 µM -0.193323919686577 0.421917331041697 no 1985 0.423352647235028 2722 17122249
SGTC_2457 5731572 11.68 µM -0.193979886905942 0.421661297511751 no 1986 0.423095815347448 2910 2865357
SGTC_1308 1187-1617 41.4 µM -0.195619373373517 0.421021527172699 no 1987 0.422454047741692 2723 2882570
SGTC_1529 apigenin 74 µM -0.197916742574434 0.420125384986938 no 1988 0.421555102301994 2991 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.19812540634415 0.420044011276143 no 1989 0.421473473718278 2748 17037758
SGTC_1081 sertraline 6 µM -0.198508343414903 0.419894684181328 no 1990 0.421323678771252 2874 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1467 k284-1082 293 µM -0.199977875149738 0.419321744498056 no 1991 0.420748942341089 2876 3334705
SGTC_815 1582-0027 36.9 µM -0.201077712632848 0.418893052694744 no 1992 0.420318904406141 2858 3128206
SGTC_3105 9121040 49.47 µM -0.201430441158466 0.418755587452004 no 1993 0.420181007193471 2694 41448907
SGTC_2198 6589944 200 µM -0.202776618192261 0.418231047101317 no 1994 0.419654817120236 2799 5290268
SGTC_2329 6138490 200 µM -0.202857618981407 0.418199489623504 no 1995 0.419623160320348 3026 720019
SGTC_2446 5162541 200 µM -0.203250023865199 0.418046618220423 no 1996 0.419469807664847 2741 1549321
SGTC_3177 9107506 49.47 µM -0.203495707730187 0.417950912060373 no 1997 0.419373800117082 2874 8897194
SGTC_2171 5739187 198.077 µM -0.204892230764414 0.417406988919638 no 1998 0.418828162702175 2718 2262761
SGTC_2729 fluphenazine 10.66 µM -0.205548794455601 0.417151322518958 no 1999 0.418571689694585 2771 3372 An atypical antipsychotic.
SGTC_1857 st056007 79.3 µM -0.205623963995728 0.417122053675617 no 2000 0.41854232847669 2853 619834
SGTC_1741 st038134 10.228 µM -0.206568975056091 0.416754132953896 no 2001 0.418173245980744 2967 1272587
SGTC_3001 9076041 71.4286 µM -0.206589773795267 0.416746036209112 no 2002 0.418165123656776 2763 16004211
SGTC_2622 2-methoxyxanthone 59.94 µM -0.208579552180846 0.415971598831474 no 2003 0.41738823723818 2841 71034 A hepatoprotective.
SGTC_2605 digitonin 300 nM -0.210102536291992 0.415379061656463 no 2004 0.416793822993321 2816 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1001 4048-4355 44.4 µM -0.210791969920321 0.41511089153397 no 2005 0.416524802420191 2785 21824233
SGTC_2439 5492030 7.2 µM -0.211029574743558 0.415018479155135 no 2006 0.416432096839285 2895 5722370
SGTC_2775 cyproheptadine 69.59 µM -0.211334528048474 0.414899879613575 no 2007 0.416313120909739 2828 2913 A selective serotonin reuptake inhibitor.
SGTC_1607 st000305 50.6 µM -0.211411513317938 0.414869940459792 no 2008 0.4162830867231 2931 5457690
SGTC_2597 laccaic acid a 100 µM -0.211855991586436 0.414697094945041 no 2009 0.416109692421626 2907 5491415 A textile dye.
SGTC_748 act1.228 77.9 µM -0.212341172352211 0.414508440188357 no 2010 0.415920438410371 2771 4421505 YNR035C ARC35
SGTC_878 0828-0289 13.7 µM -0.212873713030992 0.414301392991172 no 2011 0.415712733207622 2811 745350 YLR208W SEC13
SGTC_925 2064-1272 59.6 µM -0.212928553322731 0.414280072912768 no 2012 0.415691345353534 2807 6815817
SGTC_1904 st060225 78 µM -0.214890153676788 0.413517634608921 no 2013 0.414926480899176 2788 66595
SGTC_2352 9027995 87.8 µM -0.215663572481988 0.413217110253781 no 2014 0.414624998971503 2840 2997347
SGTC_3241 9133421 49.47 µM -0.217664590154912 0.412439818896658 no 2015 0.413845227561749 2802 17018221
SGTC_513 4245-1575 41.7 µM -0.218445775052971 0.4121364621675 no 2016 0.41354090162776 2905 719745
SGTC_2764 methyldopa 94.69 µM -0.220365695405071 0.411391124864927 no 2017 0.412793179917863 2941 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1788 fluconazole 20 µM -0.220942792472662 0.411167150867257 no 2018 0.412568488544573 2892 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_542 3381-0244 89.3 µM -0.222136448266539 0.410703979575222 no 2019 0.412103832482153 2988 1112843
SGTC_2551 apiole 73.87 µM -0.225673543568656 0.409332222650715 no 2020 0.410727668229243 2789 10659 A possible DNA adduct former.
SGTC_440 fluspirilene 35.1 µM -0.226005923439909 0.40920337579628 no 2021 0.410598406639939 3040 3396 An atypical antipsychotic.
SGTC_2204 7233102 200 µM -0.227053628960373 0.408797297641776 no 2022 0.410191020538833 2826 2172480
SGTC_452 diindolylmethane 8 µM -0.227234936642996 0.408727034870988 no 2023 0.410120531325556 2911 3071 Inhibits expression of several cancer promoting factors.
SGTC_1141 3253-0389 52.6 µM -0.228205172330715 0.408351086103043 no 2024 0.409743370293488 2854 5402031
SGTC_675 1309-0189 238 µM -0.228987282630467 0.408048093894242 no 2025 0.409439400265651 2853 4246530
SGTC_299 1273-0059 1.44 µM -0.229307769714814 0.40792395196954 no 2026 0.409314857501328 2911 2848077
SGTC_193 1273-0060 1.558 µM -0.22992201309435 0.407686048240298 no 2027 0.409076185271837 2796 2847393 YHR072W ERG7
SGTC_2381 9035592 200 µM -0.233247692519592 0.406398566441964 no 2028 0.407784536848333 2871 4749657
SGTC_1196 1588-0294 184 µM -0.233659866322939 0.406239070324323 no 2029 0.407624523659872 2870 6144269
SGTC_1494 4358-1428 177 µM -0.234977458924326 0.405729314879823 no 2030 0.40711311431069 2955 1564571
SGTC_3253 9135987 49.47 µM -0.237101304223524 0.404907969968785 no 2031 0.406289100294628 2948 4182430
SGTC_611 3453-1652 23.7 µM -0.237266000155952 0.404844295318087 no 2032 0.406225218503409 2919 1560575
SGTC_2951 9072950 58.06 µM -0.238258419779931 0.404460659978386 no 2033 0.405840334492043 2825 16488155
SGTC_2698 st077697 67.5 µM -0.241120152552849 0.403354927842326 no 2034 0.404730997009846 2877 3154499
SGTC_3147 9097027 49.47 µM -0.242159254059517 0.40295362468326 no 2035 0.404328383030948 2865 25236841
SGTC_832 4083-0019 164 µM -0.242298479870407 0.402899863141358 no 2036 0.404274445787746 2961 1990758
SGTC_1385 3091-4834 14.1 µM -0.244123221795588 0.402195415726614 no 2037 0.403567694073262 2949 4072814
SGTC_2866 9034245 58.44 µM -0.244287950629031 0.402131837230979 no 2038 0.403503907420132 2920 6462273
SGTC_1740 st038286 13.222 µM -0.246287256786572 0.401360394901333 no 2039 0.40272993690082 3050 716786
SGTC_2666 tannic acid 100 µM -0.247508158672776 0.400889492583374 no 2040 0.402257489091185 2924 16134267 A thiamine antagonist.
SGTC_1006 4099-6547 255 µM -0.248008144598722 0.40069668933642 no 2041 0.402064052579028 2942 3146833
SGTC_3020 9089140 49.47 µM -0.248147708972374 0.4006428752092 no 2042 0.402010061647821 2926 17217859
SGTC_1106 tegaserod maleate 11.7 µM -0.248240915576971 0.400606937058339 no 2043 0.401974005411412 2892 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2765 myclobutanil 7.74 µM -0.249364730545177 0.400173688242002 no 2044 0.401539332251169 2956 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1115 galangin 695.678 nM -0.250530338434929 0.39972445734399 no 2045 0.401088622956414 2916 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2418 pentamidine 31.67 µM -0.2518617299841 0.399211495004267 no 2046 0.40057397060567 2850 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2438 5259590 200 µM -0.253950093649781 0.398407235067085 no 2047 0.399767056924603 2960 1201127
SGTC_1277 0873-0036 22 µM -0.254064922689784 0.398363025173959 no 2048 0.39972270101395 2940 5965735
SGTC_3089 9117425 49.47 µM -0.255248441571621 0.397907439168039 no 2049 0.399265609425855 2916 9401657
SGTC_1093 fluphenazine 7.97 µM -0.255424685122954 0.397839607531702 no 2050 0.399197553491021 2864 6602611 An atypical antipsychotic.
SGTC_2956 9076196 2.52 µM -0.257028952840361 0.397222308143537 no 2051 0.398578211285597 2979 16423868
SGTC_2991 9074669 71.4286 µM -0.257604237010903 0.397001009592965 no 2052 0.398356179695994 3061 17333109
SGTC_1287 0971-0001 34.6 µM -0.258612909532556 0.396613076624402 no 2053 0.397966960831223 2879 4665869
SGTC_2066 5222451 176 µM -0.25892296981776 0.396493848743398 no 2054 0.397847337513503 2861 2281147
SGTC_1753 st043925 64 µM -0.260852062950797 0.395752269909868 no 2055 0.397103296727044 2978 670181
SGTC_1345 1488-0192 31.4 µM -0.261253760195225 0.395597897473847 no 2056 0.39694841127405 3012 658348
SGTC_1379 2144-0755 36.5 µM -0.261946634123616 0.395331664205104 no 2057 0.396681292828129 3029 5392327
SGTC_885 0865-0106 16.8 µM -0.262370362992706 0.395168872612865 no 2058 0.396517959721959 2872 2793380
SGTC_2045 5106652 78.05 µM -0.2626278354138 0.395069963704667 no 2059 0.396418721703893 3009 673349
SGTC_2518 prenyletin 46.28 µM -0.26275557115246 0.395020896093981 no 2060 0.396369490798299 2973 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1678 st019265 80.2 µM -0.264355722834924 0.394406365091176 no 2061 0.395752913138662 3103 5367020
SGTC_896 0964-0007 44.5 µM -0.264695407738289 0.394275944397248 no 2062 0.395622057724095 2921 6756758
SGTC_2216 7189485 200 µM -0.265264966264394 0.394057291227026 no 2063 0.395402675450511 2986 731273
SGTC_2096 5468907 200 µM -0.266113069589001 0.3937317667713 no 2064 0.395076064866963 3013 759785
SGTC_2746 daunorubicin 9.88 µM -0.26762209291952 0.393152747478915 no 2065 0.394495111700403 2883 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1757 st041620 31.8375 µM -0.267914283005402 0.393040660045306 no 2066 0.394382649616623 2950 5289815
SGTC_110 0850-0284 111.64 µM -0.26819634991685 0.392932464387772 no 2067 0.394274092228623 2808 3906265
SGTC_2485 5633444 17.78 µM -0.269442034980843 0.392454741635328 no 2068 0.393794771267752 2978 5724239
SGTC_514 4466-0038 2.65 nM -0.269912951763658 0.392274186252811 no 2069 0.393613611401664 2926 5722064
SGTC_3154 9100113 49.47 µM -0.270309862349112 0.392122023779056 no 2070 0.393460939313873 2905 25237525
SGTC_2241 6772625 37.8075 µM -0.271417462084228 0.391697493753096 no 2071 0.393034986570179 2839 2285411
SGTC_1060 3448-7350 82 µM -0.272871514028778 0.391140368453508 no 2072 0.392475992169312 3016 570178
SGTC_1951 sophoraflavanone G 9.2 µM -0.272947424187408 0.391111289323003 no 2073 0.392446815418265 2880 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_489 paxilline 115 µM -0.274536540427831 0.390502681819837 no 2074 0.391836163350321 2954 105008 A toxic potassium channel blocker.
SGTC_3069 9117009 49.47 µM -0.2753645495141 0.390185673033977 no 2075 0.391518088521016 2949 41904981
SGTC_2926 9010726 65.15 µM -0.275432116968816 0.390159807603679 no 2076 0.391492136077344 3017 2994293
SGTC_1011 4112-3381 17.4 µM -0.276282739810288 0.389834223147428 no 2077 0.391165455908818 3054 2877139
SGTC_3191 9110352 49.47 µM -0.277523813014092 0.389359328578139 no 2078 0.390688961749042 2884 17122424
SGTC_1427 4048-4900 550 nM -0.278594309544148 0.388949837549963 no 2079 0.390278090103176 3016 24132586
SGTC_639 0833-0042 114 µM -0.27937446241231 0.38865148771816 no 2080 0.389978733598968 2924 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_178 4092-0806 87.505 µM -0.279401667630855 0.388641084950879 no 2081 0.389968295719618 2975 2169044
SGTC_3244 9134489 49.47 µM -0.27999285736756 0.388415044777015 no 2082 0.389741492405689 2975 16584271
SGTC_2560 caryophyllene 100 µM -0.281577377122857 0.38780939347372 no 2083 0.389133794510058 2869 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_117 lucigenin 22.078 µM -0.281876505637458 0.387695088092751 no 2084 0.389019102573157 2969 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_313 3474-0040 5.03 µM -0.282030353365902 0.387636302357387 no 2085 0.388960118000189 2882 1043375 YIL048W NEO1
SGTC_2131 toluylene red 5.2905 µM -0.283240749364702 0.387173895916782 no 2086 0.388496146633795 2933 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3061 glucosamine 200 µM -0.284252887938355 0.386787352419816 no 2087 0.388108293762521 2992 91431 and experimental redox chemotherapeutic
SGTC_692 k241-0027 77.8 µM -0.28437589881748 0.386740381264653 no 2088 0.38806116342376 3078 3600480
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.284432421033517 0.386718799064984 no 2089 0.388039508077408 2920 4174840
SGTC_1038 k292-0204 154 µM -0.284754471684147 0.386595835317523 no 2090 0.387916127515108 2878 4454212
SGTC_88 0180-0332 8.668 µM -0.285632010698479 0.386260835629402 no 2091 0.387579991710046 2871 3101745
SGTC_873 0591-4978 488 µM -0.286071131396795 0.386093233525541 no 2092 0.387411820895924 3114 3305145
SGTC_937 3122-0005 46.7 µM -0.286749759822423 0.385834258739152 no 2093 0.38715196695237 3066 759535
SGTC_1889 st059080 5.18 µM -0.287296699891676 0.385625575223117 no 2094 0.386942574653229 3073 176925 Isolated from Daphnopsis sellowiana.
SGTC_2973 9094665 17.96 µM -0.287505496264051 0.385545918254832 no 2095 0.386862647051087 3128 25237061 YIL048W NEO1
SGTC_3043 9092303 49.47 µM -0.28843512544203 0.385191318230447 no 2096 0.386506841720504 2948 25236084
SGTC_2011 4012611 177 µM -0.288808338345109 0.385048985972183 no 2097 0.38636402541152 2904 2049887
SGTC_1121 fusaric acid 630.51 nM -0.290259542126023 0.384495687525483 no 2098 0.385808843893452 2932 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3032 9089427 49.47 µM -0.290272812682862 0.384490628962386 no 2099 0.385803768104103 3022 17173707
SGTC_1518 st038567 90.8 µM -0.290330320302987 0.384468708035335 no 2100 0.385781772526176 2929 77966
SGTC_1646 st011709 75.6 µM -0.291565107452303 0.383998117404011 no 2101 0.385309578483714 3036 5757843
SGTC_1792 st045773 43.6 µM -0.291911855227275 0.383865998826028 no 2102 0.385177009461279 2902 2919270
SGTC_3070 9117005 49.47 µM -0.292017504238875 0.383825746895941 no 2103 0.385136620271563 2947 8779016
SGTC_1870 st057514 26.5 µM -0.29212389271285 0.383785214499673 no 2104 0.385095949647529 2886 5393161
SGTC_2568 diosmetin 100 µM -0.292623118273812 0.383595034114432 no 2105 0.384905120532181 3093 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_443 clozapine 122 µM -0.292754152387861 0.383545121205462 no 2106 0.384855037320818 2931 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_707 0865-0008 204 µM -0.292854950401251 0.383506727007165 no 2107 0.384816512109717 2940 723043
SGTC_2320 7373003 200 µM -0.292880678731957 0.38349692720925 no 2108 0.384806678870189 2985 5415828
SGTC_2944 9067346 25.62 µM -0.293832669721099 0.383134370850932 no 2109 0.38444288481223 3094 6473075
SGTC_1840 st055363 71 µM -0.295362364439357 0.38255201620089 no 2110 0.383858540144533 2953 676033
SGTC_2825 7998094 58.44 µM -0.295641746726002 0.382445684021629 no 2111 0.383751844346289 2981 2987815
SGTC_166 k072-0058 166.424 µM -0.295717089765744 0.382417010171613 no 2112 0.383723072427891 3027 5846229
SGTC_1016 4226-1401 38 µM -0.297411217604932 0.381772434093037 no 2113 0.383076290266625 2908 2901613
SGTC_3230 9131665 49.47 µM -0.299116137924108 0.381124082502752 no 2114 0.382425716689112 2928 15943720
SGTC_1270 0831-1170 17.3 µM -0.301405583961721 0.380253970889357 no 2115 0.381552618399273 2924 6764716
SGTC_1156 4092-0367 4.88 µM -0.302448544779908 0.379857790662023 no 2116 0.381155076499273 2966 1357585
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.302607336729369 0.379797482827426 no 2117 0.381094561289188 3273 5282309
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.30285777260972 0.37970237534735 no 2118 0.380999126718816 2897 5355888
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.303417976699021 0.379489654233136 no 2119 0.380785673790537 2998 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_358 0075-0058 9.45 µM -0.305229731145741 0.378801943508466 no 2120 0.380095594985668 2948 1069125
SGTC_3092 9117248 49.47 µM -0.305983295911916 0.37851601614105 no 2121 0.379808682069152 2974 17141857
SGTC_2298 7976326 193.81 µM -0.306035714288104 0.378496129349245 no 2122 0.37978872670916 2927 2235818
SGTC_3048 9093155 49.47 µM -0.306254739932558 0.37841303759419 no 2123 0.37970534842982 3035 25236002
SGTC_3114 9122766 49.47 µM -0.306300388903304 0.378395720452742 no 2124 0.379687971567778 3004 17176985
SGTC_3065 9113888 49.47 µM -0.307419112674096 0.377971403995537 no 2125 0.379262191137955 3139 16648368
SGTC_2585 alliin 100 µM -0.309925430470545 0.37702132718435 no 2126 0.378308831806033 3139 87310 A garlic compound which reacts with lipids.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.310641235281433 0.376750121426211 no 2127 0.378036687872571 2899 107982 A Capsaicinoid.
SGTC_1015 4130-4525 82 µM -0.31246222318411 0.376060455790731 no 2128 0.377344634183119 2973 1363237
SGTC_183 3914-0051 30.55 µM -0.313116122117434 0.37581290003695 no 2129 0.377096220428653 3104 1596232
SGTC_2372 9071633 200 µM -0.313698183525558 0.375592583818788 no 2130 0.376875140260679 3088 21321366
SGTC_1605 st000082 49.1 µM -0.313858739640672 0.375531818815312 no 2131 0.376814164494305 3079 1114022
SGTC_1096 rimcazole 32.2 µM -0.314167848436009 0.375414840393708 no 2132 0.376696780261851 2936 18528119 A dopamine reuptake inhibitor.
SGTC_955 1216-0110 33 µM -0.314416023831414 0.375320929757156 no 2133 0.376602543770365 2904 3619719
SGTC_1101 ebselen 5.29 µM -0.316441783030787 0.374554650527392 no 2134 0.375833603389159 3117 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2888 9058547 12.99 µM -0.318497285864456 0.373777626311492 no 2135 0.375053876558876 2959 16476514
SGTC_1712 st032288 53.4 µM -0.320274793814147 0.373106103384319 no 2136 0.374380014613292 3062 2883011
SGTC_789 1309-1135 70.6 µM -0.322375151552446 0.372313108101344 no 2137 0.373584253212071 2944 3092424
SGTC_2178 5812956 200 µM -0.322562173838958 0.372242523559799 no 2138 0.373513422249097 2920 5403383
SGTC_2763 lisinopril 49.32 µM -0.325054105199992 0.371302448055926 no 2139 0.372570061546051 2992 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_539 4859-0462 2.54 µM -0.326056841018426 0.370924384393413 no 2140 0.372190674995284 3136 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1825 st052143 62.6 µM -0.326297410561919 0.370833700449646 no 2141 0.372099673593026 3152 674173
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.326485989571376 0.370762619624452 no 2142 0.372028343895063 2992 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_575 k072-0246 11.9 µM -0.326793756251462 0.370646623029198 no 2143 0.37191194109114 2974 6796779
SGTC_2430 5571206 200 µM -0.326991197960354 0.370572213866768 no 2144 0.371837271306904 3139 1731771
SGTC_1779 st039427 55 µM -0.328137319829133 0.370140374650664 no 2145 0.371403918808694 3199 1124498
SGTC_340 k038-0059 454 µM -0.3289629975477 0.36982937471589 no 2146 0.371091828260515 3002 23733424
SGTC_3040 9091894 49.47 µM -0.329293231176548 0.369705012669446 no 2147 0.370967029917954 2970 25236966
SGTC_2696 st077691 74.316 µM -0.329310044635083 0.369698681285941 no 2148 0.370960676319415 3145 757133
SGTC_3295 9122362 53.5725 µM -0.333069480122841 0.368283894195394 no 2149 0.369540918335759 3091 4730473
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.333788229575423 0.368013610038697 no 2150 0.369269682990276 3041 1241132 A phosphatase inhibitor.
SGTC_853 0419-0306 21 µM -0.334125931074224 0.367886640679742 no 2151 0.369142266628603 2982 762713
SGTC_1570 verbenone 133 µM -0.337632629685125 0.366569043994358 no 2152 0.367820024874207 3189 29025 A natural terpanoid with antifungal properties.
SGTC_363 0455-0021 3.06 µM -0.337841560013707 0.366490590559907 no 2153 0.367741294491917 2969 4597466
SGTC_633 0437-0093 97.7 µM -0.338021356886133 0.366423081217464 no 2154 0.36767354680231 3011 2831118
SGTC_39 0986-0283 58.349 µM -0.33833697331024 0.366304584941322 no 2155 0.367554632091795 3186 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_232 clozapine 119 µM -0.338684827780692 0.36617399985213 no 2156 0.367423585771415 3000 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1181 1222-0449 220 µM -0.339139575853385 0.366003310119023 no 2157 0.367252292984229 3184 658318
SGTC_2920 7982904 15.77 µM -0.33924435996295 0.365963983151113 no 2158 0.36721282704488 3100 6456808
SGTC_1523 st012844 44.7 µM -0.339783672180495 0.365761593883597 no 2159 0.367009722422176 3118 4274103
SGTC_1087 pterostilbene 9.05 µM -0.342130387871349 0.36488137064807 no 2160 0.366126384816335 3140 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2962 9082311 13.18 µM -0.342947006190569 0.364575234164564 no 2161 0.365819163964834 2959 16459453
SGTC_377 3970-0964 33.1 µM -0.343104055900706 0.36451636876155 no 2162 0.365760089982944 2996 16481235
SGTC_101 0490-5701 117.494 µM -0.343262627851533 0.364456936033345 no 2163 0.365700446642315 3071 4661669
SGTC_11 0438-0307 1.3 µM -0.344199666221929 0.364105800841427 no 2164 0.365348066650522 3113 4011476
SGTC_1983 st071813 46.9 µM -0.344738026191227 0.363904113464836 no 2165 0.365145663907969 3075 11838595
SGTC_1374 2889-5571 141 µM -0.345673228650752 0.363553845469561 no 2166 0.364794152905515 3067 2853281
SGTC_591 4299-0174 154 µM -0.346441404086071 0.363266220569961 no 2167 0.364505506695752 3062 5509088
SGTC_1638 st008370 60.6 µM -0.34686552941092 0.363107450013932 no 2168 0.364346172136757 3019 24207134
SGTC_1715 st032160 10.2275 µM -0.347126886501965 0.363009623166442 no 2169 0.364247997694701 3128 5289825
SGTC_660 4031-1742 102 µM -0.347477940283908 0.362878236608922 no 2170 0.364116144200242 3020 6738706
SGTC_1883 5-benzylidenerhodanine 20 µM -0.349408521845514 0.362155979535247 no 2171 0.363391318254292 3130 1273210
SGTC_2435 5706476 10.6 µM -0.350742625163542 0.361657159587849 no 2172 0.362890722137723 3171 5725375
SGTC_1935 st074532 41.6 µM -0.350954553374813 0.361577941442324 no 2173 0.36281122176658 3124 2829742
SGTC_2135 5326629 150.42 µM -0.352439995071089 0.361022854381517 no 2174 0.362254155977913 3066 5020077
SGTC_1856 st057054 55.7 µM -0.35258538007413 0.360968541907707 no 2175 0.362199649787238 3240 1266018
SGTC_2893 9048488 25.97 µM -0.353919055004243 0.360470442739385 no 2176 0.361699773144461 3054 6467338
SGTC_2558 carylophyllene oxide 100 µM -0.354564517670154 0.360229461126705 no 2177 0.361457931004 3003 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_111 0083-0039 52.457 µM -0.35566942272741 0.359817076945839 no 2178 0.36104407335144 2986 759313
SGTC_2545 solidagenone 89.61 µM -0.357348725813459 0.359190622470323 no 2179 0.360415378402761 2941 6708572 An anti ulcer agent
SGTC_1926 methyl fluorone black 53.6 µM -0.358182418254237 0.358879758689542 no 2180 0.36010340189243 3055 72721 Reacts with homocysteine.
SGTC_2636 apigenin dimethyl ether 100 µM -0.358273986581434 0.358845620762936 no 2181 0.360069141731749 3181 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2931 9014674 55.67 µM -0.358563111826958 0.358737838312497 no 2182 0.359960973306514 2995 2996810
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.360094912648902 0.358166989043973 no 2183 0.359388078542348 3019 442882
SGTC_806 3966-4455 5.86 µM -0.360572380905773 0.357989117840282 no 2184 0.359209569551297 3052 714982
SGTC_1242 0402-0103 60.1 µM -0.361116334869153 0.357786516285062 no 2185 0.35900624128509 3011 432868
SGTC_1668 st014914 51.6 µM -0.361687771906839 0.357573721505428 no 2186 0.358792682947408 3116 2839556
SGTC_3174 9107204 49.47 µM -0.362920642268446 0.357114769505282 no 2187 0.358332083126045 3168 3938802
SGTC_487 nimodipine 119 µM -0.363782391612389 0.35679409479239 no 2188 0.358010256258795 3089 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1182 1222-0449 220 µM -0.363937014100998 0.356736567272793 no 2189 0.357952521978306 3112 658318
SGTC_2511 berberine 10.47 µM -0.365393115802121 0.356194982520145 no 2190 0.357408989663646 3052 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2049 5262831 67.185 µM -0.365859980720811 0.356021397387083 no 2191 0.357234779913294 3118 763417
SGTC_1340 1486-1359 257 µM -0.366062154639697 0.355946236321142 no 2192 0.357159348332908 3057 4309068
SGTC_2875 9039966 71.43 µM -0.36659599576172 0.355747800110625 no 2193 0.356960197751069 3112 6463691
SGTC_2596 sinensetin 100 µM -0.367619531317335 0.355367446971373 no 2194 0.356578474635384 3083 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2374 9071832 200 µM -0.367648804866329 0.355356570827638 no 2195 0.356567559303786 3070 17381698
SGTC_347 4534-1311 26.2 µM -0.367666847061207 0.355349867582085 no 2196 0.356560831905376 3020 2862016
SGTC_264 promethazine 12.5 mM -0.369388655467472 0.354710367538017 no 2197 0.355919026324188 3155 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2484 5809818 12.04 µM -0.369890785205914 0.354523947597891 no 2198 0.355731933809454 3082 2870548
SGTC_3110 9122132 49.47 µM -0.370875142038969 0.354158597879464 no 2199 0.355365265324664 3221 918317
SGTC_152 4469-0003 551.229 µM -0.371469069324051 0.353938223234202 no 2200 0.355144094805422 3121 697280
SGTC_773 4358-1457 44.6 µM -0.371582274225195 0.353896224499868 no 2201 0.355101944359445 3217 1186886
SGTC_1898 st060199 18.6 µM -0.373780409499563 0.353081074786489 no 2202 0.354283847876453 3039 688866
SGTC_469 w7 172 µM -0.375025474329882 0.35261965740989 no 2203 0.353820760613193 3110 45115570 A P450 inhibitor.
SGTC_1238 0333-0287 48.8 µM -0.375057571804729 0.352607765042895 no 2204 0.353808825189532 3088 7226
SGTC_742 0kpi-0133 140 µM -0.3758810152753 0.352302722038901 no 2205 0.353502677463808 3215 2728852
SGTC_2031 5180455 200 µM -0.377978407165641 0.351526176857878 no 2206 0.352723317361909 3052 29949
SGTC_1971 st069429 63.5 µM -0.378041735998858 0.35150273939993 no 2207 0.352699794885992 3187 1246522 YGL099W LSG1
SGTC_380 3970-0968 6 µM -0.378055463020184 0.351497659221529 no 2208 0.352694696279096 3053 2891601
SGTC_3108 9121785 49.47 µM -0.38118882879291 0.350338740089321 no 2209 0.351531568912165 3101 17140271
SGTC_1736 st036774 51 µM -0.38181028226313 0.350109051915547 no 2210 0.351301045705082 3292 1272247
SGTC_804 1595-0054 20.9 µM -0.384620089763515 0.349071237086054 no 2211 0.350259453798204 3078 761523 Stimulates phospholipase C.
SGTC_1746 st038117 42 µM -0.386248284574796 0.348470371710901 no 2212 0.349656398547576 3155 2898218
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.386548815529469 0.34835950594002 no 2213 0.349545128478265 3119 6708630 An antioxidant.
SGTC_679 0422-0091 41.4 µM -0.386687074265638 0.348308506687575 no 2214 0.349493943219391 3074 627384 YHR062C RPP1
SGTC_2661 dactinomycin 12.96 µM -0.387006205642809 0.348190799740289 no 2215 0.349375806905473 3110 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.387238700657116 0.348105056555903 no 2216 0.349289750896709 3065 803109
SGTC_2267 7931562 200 µM -0.387258256983875 0.348097844618731 no 2217 0.349282512645525 3027 934880
SGTC_1644 st010134 20.9 µM -0.389922849858622 0.347115716868371 no 2218 0.348296798436225 3219 3818134
SGTC_729 4092-0585 94.1 µM -0.39107844210423 0.346690101981622 no 2219 0.34786962747927 3067 2169061
SGTC_837 0091-0265 12.5 µM -0.392379733817806 0.346211056235897 no 2220 0.347388828988679 3096 759367
SGTC_2945 9067681 61.76 µM -0.392509190037252 0.346163412834795 no 2221 0.347341011191862 3153 16456930
SGTC_3206 9114350 49.47 µM -0.393978514742041 0.345622832276106 no 2222 0.346798450899759 3190 17087243
SGTC_847 0342-0274 5.54 µM -0.395280600533174 0.345144043644016 no 2223 0.346317907341773 3213 18097
SGTC_2384 9036245 200 µM -0.395461451963473 0.345077562529899 no 2224 0.346251182440974 3125 6462766
SGTC_2449 5812982 45.77 µM -0.396089214969379 0.344846833518408 no 2225 0.346019607136075 3183 776185
SGTC_2686 alizarin 95.37 µM -0.397507459817868 0.344325782050389 no 2226 0.345496643307734 3138 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1835 st008666 49.2 µM -0.397956586212172 0.344160838238953 no 2227 0.345331093777137 3079 690455
SGTC_1180 1193-0155 285 µM -0.398774000799846 0.343860714919714 no 2228 0.345029867899537 3220 2921347
SGTC_1751 st044839 27.194 µM -0.400327391295461 0.343290640641055 no 2229 0.344457697847783 3180 5291326
SGTC_3255 9139072 49.47 µM -0.400631921442251 0.343178923746184 no 2230 0.344345570016358 3179 17646060
SGTC_3183 9108214 49.47 µM -0.403276459603036 0.342209351987775 no 2231 0.343372428653224 3184 4974831
SGTC_2716 st080858 38.6235 µM -0.403371075428933 0.342174682037915 no 2232 0.343337630956775 3244 5296050
SGTC_2981 9013952 38.96 µM -0.40454581399864 0.341744335043257 no 2233 0.342905697684448 3135 2996344
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.405170998585667 0.341515392286955 no 2234 0.34267591058309 3087 6312947
SGTC_2123 5259487 200 µM -0.406377658251422 0.341073678118389 no 2235 0.342232566478823 3227 2173474
SGTC_1614 st002383 48.6 µM -0.409503797391782 0.339930326334435 no 2236 0.341084990296774 3205 1947235
SGTC_1496 4469-0713 57.4 µM -0.412806635491076 0.338723946474347 no 2237 0.33987414475303 3239 746691
SGTC_194 1486-1323 56.904 µM -0.412960829897392 0.338667666399861 no 2238 0.339817656135254 3169 5178754
SGTC_1319 1306-0155 43.7 µM -0.415887607961049 0.337600093524008 no 2239 0.338746123883009 3148 3122360
SGTC_1430 4049-0248 69.1 µM -0.418026969893955 0.336820564272062 no 2240 0.337963699314094 3234 22774488
SGTC_1940 st075990 51.1 µM -0.418304938009688 0.336719331086484 no 2241 0.337862089868718 3382 1084979
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.419299244638526 0.336357311522356 no 2242 0.337498724273867 3247 521171
SGTC_2210 7115885 190.385 µM -0.4193975903383 0.33632151283016 no 2243 0.337462792436436 3169 2927039
SGTC_3064 1327-0027 10 µM -0.419879583397344 0.336146084618264 no 2244 0.337286711650513 3134 16000455 YPR107C YTH1
SGTC_1803 st050068 52.4 µM -0.420138523262742 0.336051854510692 no 2245 0.337192130943085 3250 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1968 st069590 43.6 µM -0.420635382791518 0.335871072554983 no 2246 0.337010676211279 3235 6384066
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.422317673709558 0.335259254429722 no 2247 0.336396579808834 3266 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1849 st056239 19.2 µM -0.422731720965134 0.335108740002334 no 2248 0.336245504565609 3117 5393181
SGTC_250 brefeldin a 552.239 µM -0.422864696627323 0.335060406314885 no 2249 0.336196990759284 3134 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2416 tofa 880 nM -0.423347891540673 0.334884798739452 no 2250 0.336020728656023 3127 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2627 acetyl isogambogic acid 100 µM -0.423360099324599 0.334880362530686 no 2251 0.336016275910225 3232 6857789 A caspase activator and apoptosis inducer.
SGTC_2058 5236698 133 µM -0.424873699700599 0.334330511242065 no 2252 0.335464374037875 3160 766665
SGTC_3301 9125354 19.7965 µM -0.425188784090688 0.334216093989557 no 2253 0.33534952986476 3163 41905162
SGTC_497 capsazepine 133 µM -0.425317730065604 0.334169274009449 no 2254 0.335302535165322 3167 2733484 A calcium channel blocker.
SGTC_2464 5717415 7.67 µM -0.425413453610267 0.334134518684282 no 2255 0.335267650134635 3155 5285744
SGTC_1421 4029-0249 71.4 µM -0.428164736378558 0.333136191253699 no 2256 0.334265594016557 3305 2894095
SGTC_442 cape 100 µM -0.428255283770483 0.333103355367354 no 2257 0.334232635393056 3281 5281787
SGTC_1569 carminic acid 40.6 µM -0.429024047416053 0.332824624351325 no 2258 0.333952862260316 3314 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3304 9125678 46.087 µM -0.431224532262209 0.332027304462309 no 2259 0.333152558905195 3154 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_973 1325-0077 65.9 µM -0.432374702953462 0.331610855768891 no 2260 0.332734550473188 3188 2835149
SGTC_2846 9008642 19.48 µM -0.434228817762242 0.330939964288904 no 2261 0.332061144207121 3268 2992898
SGTC_1461 k072-0203 53.8 µM -0.435554827778977 0.330460494438084 no 2262 0.331579875535295 3201 5418714
SGTC_2252 omeprazole 400 µM -0.436398722910066 0.330155496527948 no 2263 0.331273732691428 3127 4594 A proton pump inhibitor.
SGTC_1157 4092-0394 27.6 µM -0.436879090638951 0.329981933921405 no 2264 0.33109951831244 3356 3659885
SGTC_1805 st050013 60.3 µM -0.437501151623568 0.329757230222103 no 2265 0.330873970540224 3189 4037144
SGTC_3280 9140961 49.47 µM -0.438128828128739 0.329530560322131 no 2266 0.330646448893241 3139 4901226
SGTC_1938 st074717 56.4 µM -0.438292523535759 0.329471456051588 no 2267 0.33058712248176 3216 17250979
SGTC_206 4546-0025 72.014 µM -0.439959003274425 0.32886999539029 no 2268 0.329983400138889 3254 6620745 YIL048W NEO1
SGTC_1846 st056244 14.8 µM -0.440341764440547 0.328731912914338 no 2269 0.329844798142698 3218 5393182
SGTC_2217 6934799 96.0675 µM -0.44078570052852 0.328571790645796 no 2270 0.329684073297793 3251 675606
SGTC_812 4251-0442 148 µM -0.440841500507898 0.328551666507896 no 2271 0.329663873418045 3283 5723007
SGTC_1463 k081-0032 34.1 µM -0.441009880926689 0.328490943500615 no 2272 0.329602921851937 3238 977755
SGTC_2053 5265679 138 µM -0.441106179938463 0.328456217237168 no 2273 0.329568064871028 3152 764595
SGTC_407 eburnamonine 100 µM -0.441107211371233 0.328455845301536 no 2274 0.329567691535311 3152 3195
SGTC_2312 7706453 155.7 µM -0.44155776948701 0.328293389879452 no 2275 0.329404624504541 3175 976098
SGTC_3178 9107506 49.47 µM -0.441590105863033 0.328281731766945 no 2276 0.329392922496146 3302 8897194
SGTC_718 1130-0073 349 µM -0.442762418755779 0.32785919519576 no 2277 0.328968794450074 3344 6740020
SGTC_1597 7-benzyloxygramine 47.5 µM -0.444775519319081 0.327134127754297 no 2278 0.328240993737997 3225 260807
SGTC_1306 1185-0270 9.02 µM -0.44560203624774 0.326836626067034 no 2279 0.32794236971934 3281 1548076
SGTC_1208 2323-2347 50.3 µM -0.445974410521737 0.326702627281374 no 2280 0.327807865259993 3313 5412760
SGTC_1367 1812-0510 76.9 µM -0.446068393072232 0.326668811216769 no 2281 0.327773921567348 3235 1142582 YDR527W RBA50
SGTC_1954 st077032 68.9 µM -0.446803727048225 0.326404278283943 no 2282 0.327508390020004 3237 698907
SGTC_2388 9080168 200 µM -0.447149451235031 0.326279935795575 no 2283 0.327383578003625 3169 15943073
SGTC_627 1391-0720 175 µM -0.447348296752692 0.326208428147996 no 2284 0.327311800298236 3242 997839
SGTC_3290 9121031 71.43 µM -0.447492520886828 0.326156567116134 no 2285 0.327259743388843 3221 17014854
SGTC_284 0988-0104 32.6 µM -0.448100769935226 0.32593788604885 no 2286 0.327040236206399 3243 4666532
SGTC_2708 st078559 56 µM -0.44888391138753 0.325656414853709 no 2287 0.326757701304211 3284 17250902
SGTC_1166 k206-0078 225 µM -0.449185049175728 0.325548208469892 no 2288 0.326649085881684 3202 5404595
SGTC_593 1203-0218 61.7 µM -0.449830502089938 0.325316330528651 no 2289 0.326416331184844 3312 3666956
SGTC_2391 6285546 200 µM -0.451041747742859 0.324881374981103 no 2290 0.325979730225669 3175 846083
SGTC_208 k072-0098 12.366 µM -0.451118328964477 0.324853882853515 no 2291 0.325952134062038 3212 5948901
SGTC_2246 7293507 91.5585 µM -0.452928323586687 0.324204385313264 no 2292 0.325300177480135 3289 887656
SGTC_1764 st044502 93.5 µM -0.453692402063036 0.323930364142018 no 2293 0.325025118153788 3309 8407
SGTC_3145 9085516 49.47 µM -0.453859412061999 0.323870482108475 no 2294 0.324965009196894 3269 25236195
SGTC_1795 st049545 62.3 µM -0.453983242792326 0.323826085099235 no 2295 0.324920443932267 3286 5291882
SGTC_776 4476-4378 112 µM -0.45569282701594 0.323213404585636 no 2296 0.324305440390316 3286 2892008
SGTC_2831 7999036 19.48 µM -0.457210672136617 0.322669841011907 no 2297 0.323759814141612 3374 2988270
SGTC_1456 k015-0012 13 µM -0.458305992528248 0.322277825188571 no 2298 0.323366309731017 3383 2989616
SGTC_948 3448-0295 75.3 µM -0.46097073686141 0.321324937329465 no 2299 0.322409800043175 3272 678569
SGTC_1694 st024011 44.9 µM -0.461048750961355 0.321297057883089 no 2300 0.3223818145562 3310 2787533
SGTC_1336 1486-0901 104 µM -0.461550948387599 0.321117614611178 no 2301 0.322201688664526 3274 5006114
SGTC_3120 9124077 49.47 µM -0.462658717889537 0.320721938338531 no 2302 0.321804506589388 3275 18774327 YGL155W CDC43
SGTC_412 gemfibrozil 100 µM -0.463036887835558 0.320586909109362 no 2303 0.321668963295003 3294 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3264 9137442 49.47 µM -0.464102999750173 0.320206371408426 no 2304 0.321286976336491 3419 17015726
SGTC_2249 haloperidol 116.36 µM -0.464785872937095 0.319962726120317 no 2305 0.321042402731632 3269 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2924 9010168 62.78 µM -0.46531145037033 0.319775255931895 no 2306 0.320854218044321 3292 2993929
SGTC_167 3672-0051 66.205 µM -0.466596857532218 0.319316953249716 no 2307 0.320394167859603 3196 3237971
SGTC_2016 5121758 140 µM -0.467305089218277 0.319064556184126 no 2308 0.320140807929831 3271 2795203
SGTC_3344 9148862 3.898 µM -0.468575803673829 0.318611913796117 no 2309 0.319686437918864 3367 4905352
SGTC_2938 9059746 27.26 µM -0.468802696610726 0.318531120497221 no 2310 0.319605336137888 3298 6471769
SGTC_1509 1326-1131 80 µM -0.468992449824333 0.318463558742396 no 2311 0.319537516394656 3309 768313
SGTC_1213 1315-0166 115 µM -0.469613305989224 0.318242544697751 no 2312 0.319315658226562 3276 768401
SGTC_465 cgp-37157 41 µM -0.471965750098271 0.317405702781376 no 2313 0.318475617805889 3263 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2160 5660466 132.927 µM -0.472604731079419 0.317178557038261 no 2314 0.318247603249709 3320 2859134
SGTC_1519 esterone 74 µM -0.472685237683875 0.317149943334307 no 2315 0.318218880081552 3183 698 A steroid.
SGTC_2995 9067767 71.4286 µM -0.473114586314897 0.316997362459128 no 2316 0.318065715422436 3247 11673567
SGTC_2742 clothiapine 36.27 µM -0.475292686998812 0.316223794040114 no 2317 0.317289185405012 3286 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.476145662739764 0.315921072249194 no 2318 0.316985303795221 3213 15053
SGTC_2395 5646831 180.19 µM -0.476676189713568 0.315732850023232 no 2319 0.316796360191942 3395 6808628
SGTC_1675 st018485 24.5 µM -0.476769917888121 0.315699601776617 no 2320 0.316762984499478 3245 3323024
SGTC_2703 st077852 53.4 µM -0.476900292023243 0.31565335656857 no 2321 0.316716562016579 3332 6281836
SGTC_1415 3966-0071 78.1 µM -0.47729692589551 0.315512683713671 no 2322 0.316575349842582 3301 2893185
SGTC_2676 harmalol 100 µM -0.477975564226439 0.315272055253179 no 2323 0.316333798609285 3342 5459187 A monoamine oxidase inhibitor
SGTC_3019 9081971 49.47 µM -0.479668720079311 0.314672045563691 no 2324 0.315731486666829 3406 16451803
SGTC_785 1270-0111 65.3 µM -0.479740176543363 0.31464673402516 no 2325 0.315706077966255 3230 6741994
SGTC_902 1120-0002 2.07 µM -0.480376081275886 0.314421520181325 no 2326 0.315479999460228 3310 3280475
SGTC_988 1497-1057 103 µM -0.481055603644462 0.314180934905981 no 2327 0.315238490217718 3387 3533044
SGTC_63 0099-0242 26.702 µM -0.481165994045606 0.314141858572997 no 2328 0.315199263783966 3363 3898502 YLR359W ADE13
SGTC_271 rotenone 740 µM -0.481399889912898 0.314059070280135 no 2329 0.31511615745709 3362 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_647 0140-0236 81 µM -0.484037759476077 0.313126035366323 no 2330 0.314179535819015 3287 990837
SGTC_1657 st012939 43.4 µM -0.484156789595473 0.313083961631361 no 2331 0.314137300241032 3366 24207257
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.484718448072228 0.312885464303293 no 2332 0.313938039240463 3339 616764
SGTC_2813 7971799 71.43 µM -0.485013447530781 0.312781229421374 no 2333 0.313833403258188 3326 2234054
SGTC_1453 4237-0541 195 µM -0.485267360573013 0.312691523968169 no 2334 0.313743352569998 3350 739892
SGTC_630 4356-0227 183 µM -0.485610057594249 0.312570469433948 no 2335 0.313621832087389 3322 779312
SGTC_1295 1013-0063 9.78 µM -0.486892906948951 0.312117494425827 no 2336 0.313167112879147 3378 6826038
SGTC_1070 indatraline 8.81 µM -0.489468078855482 0.31120905689109 no 2337 0.312255174218093 3282 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_112 phenothiazine 287.218 µM -0.490032813396263 0.311009990162469 no 2338 0.312055339725211 3389 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1673 st016611 27.3 µM -0.491226734315779 0.310589319718808 no 2339 0.311633046172644 3380 5226799
SGTC_3307 9126885 69.2785 µM -0.492993267796404 0.309967347094066 no 2340 0.311008672101719 3233 24824909
SGTC_2398 5228213 48.84 µM -0.493299655874882 0.309859527234716 no 2341 0.310900435750178 3424 80771 YMR134W ERG29
SGTC_2394 5221648 200 µM -0.493350645825143 0.309841585142933 no 2342 0.310882424345075 3363 788586
SGTC_1977 st070720 65.3 µM -0.493444098460164 0.309808702667272 no 2343 0.31084941483468 3363 682188
SGTC_2351 9026858 72.31 µM -0.49396924139369 0.309623952880954 no 2344 0.310663951204332 3221 1409300
SGTC_164 4100-3994 89.624 µM -0.495331794956618 0.309144819208424 no 2345 0.310182965437536 3415 4615967
SGTC_2571 chrysanthemic acid 100 µM -0.49587450605679 0.308954068453767 no 2346 0.309991477014896 3282 2743 An insecticide.
SGTC_1760 st045453 10.4495 µM -0.497728439348139 0.308302841337103 no 2347 0.30933773011598 3379 3323419 YIL048W NEO1
SGTC_2913 7966556 36.57 µM -0.498046962875708 0.308191014898426 no 2348 0.309225470776646 3361 2976516
SGTC_2319 6033012 152.6 µM -0.498107296733233 0.308169835044469 no 2349 0.309204208924586 3230 847246
SGTC_2166 5933061 31.504 µM -0.498282061059247 0.308108488637013 no 2350 0.309142625001069 3646 2877375
SGTC_2648 atorvastatin 78.68 µM -0.49838210521199 0.308073373188302 no 2351 0.309107373586788 3380 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1766 st045414 44.774 µM -0.498640489534278 0.307982688546561 no 2352 0.309016337789522 3331 253960
SGTC_1403 3909-7815 62.9 µM -0.499634930907976 0.307633780826276 no 2353 0.308666078623436 3267 6615483
SGTC_424 splitomicin 100 mM -0.502552965725174 0.30661096979291 no 2354 0.307639302403379 3314 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_199 4063-0024 41.6 µM -0.503195902154188 0.306385813761112 no 2355 0.307413272804566 3377 306215
SGTC_550 4123-0385 25.7 µM -0.503979043298714 0.30611165683288 no 2356 0.307138051857947 3296 5731123
SGTC_1312 1218-2183 165 µM -0.504425981443469 0.30595524429598 no 2357 0.306981032110044 3395 6744073
SGTC_841 0251-0215 91.2 µM -0.50456919160814 0.305905133288564 no 2358 0.306930726540721 3344 3888614
SGTC_1508 1080-0625 72.9 µM -0.504622807555369 0.305886373340337 no 2359 0.306911893751614 3347 767111
SGTC_817 1391-0715 46 µM -0.509155311187623 0.304302318566572 no 2360 0.305321682235294 3302 1353946
SGTC_640 3381-0960 37.1 µM -0.509509760334843 0.304178597046573 no 2361 0.305197479333476 3369 1745025
SGTC_524 r073-0010 27.8 µM -0.512139885795638 0.303261245031453 no 2362 0.304276555731541 3276 2772106
SGTC_27 0485-0001 32.618 µM -0.512288540639798 0.303209433187598 no 2363 0.304224542044171 3339 2054479
SGTC_1575 cyproterone acetate 48 µM -0.512298966511993 0.30320579952477 no 2364 0.304220894225189 3309 9880 An androgen receptor antagonist and liver toxin.
SGTC_1149 3909-7961 23.3 µM -0.513893884249191 0.302650162498048 no 2365 0.3036630917814 3346 735261
SGTC_2314 7727897 200 µM -0.51440577589067 0.302471926582392 no 2366 0.303484160934722 3285 900724
SGTC_2843 9000894 45.46 µM -0.514735896521364 0.302357006612888 no 2367 0.303368792818583 3301 2242070
SGTC_3273 9137859 49.47 µM -0.516105340320656 0.301880491857925 no 2368 0.302890419153635 3406 2377234
SGTC_2331 7980721 200 µM -0.516128421556188 0.301872463351547 no 2369 0.302882359318334 3309 2981221
SGTC_566 0958-0068 16.5 µM -0.517849809436716 0.301273971685471 no 2370 0.302281531347544 3406 6815365
SGTC_922 1866-0035 480 µM -0.519097522324166 0.30084050154389 no 2371 0.301846368025939 3302 3156169
SGTC_913 3487-1245 167 µM -0.519148088001871 0.300822940365323 no 2372 0.301828738232794 3268 4016153
SGTC_759 3486-0358 89.3 µM -0.519524923826128 0.300692081947079 no 2373 0.301697368482005 3456 875103
SGTC_503 tyrphostin 8 294 µM -0.520004614690809 0.300525543698248 no 2374 0.3015301793637 3386 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2180 6301957 200 µM -0.520821443994442 0.30024205420574 no 2375 0.301245581628349 3391 845462
SGTC_1999 st074831 12.5 µM -0.521032989320485 0.300168654813293 no 2376 0.301171895234562 3312 17112523
SGTC_989 1501-0895 10.3 µM -0.522312712110332 0.299724805474362 no 2377 0.300726309845566 3428 2830112
SGTC_2163 5671233 125 µM -0.523822324316154 0.299201605536912 no 2378 0.300201062302008 3489 701023
SGTC_2117 5521686 200 µM -0.525363419430337 0.298667922198197 no 2379 0.299665289009289 3301 803312
SGTC_1134 3477-0009 42.5 µM -0.525815718614491 0.298511372567977 no 2380 0.299508126063908 3500 3973534
SGTC_1704 st028805 70.8 µM -0.52674715593131 0.298189101473463 no 2381 0.299184592047339 3376 2876101
SGTC_471 1-acyl-paf 4 µM -0.526994536903898 0.298103535947894 no 2382 0.299098691124849 3300 16759367
SGTC_2670 beta-carotene 100 µM -0.527021656210696 0.298094156449573 no 2383 0.299089274859012 3386 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1522 st012842 45.6 µM -0.527095305071513 0.298068684892621 no 2384 0.299063703451816 3346 3491067 YOR116C RPO31
SGTC_1545 lovastatin 49.4 µM -0.528961329815998 0.297423648912027 no 2385 0.298416137883549 3396 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_64 000l-0018 272.079 µM -0.530430011925805 0.296916412699313 no 2386 0.297906911130854 3370 6811119
SGTC_2983 9022671 12.99 µM -0.532389579376245 0.296240257329272 no 2387 0.297228100492289 3452 6405161
SGTC_1315 1237-0019 3.69 µM -0.534171801655157 0.295625909480815 no 2388 0.296611338277353 3429 825140
SGTC_244 nsc-207895 1.295 µM -0.53520931716517 0.295268538585266 no 2389 0.296252562133594 3313 42640
SGTC_2895 9054447 58.44 µM -0.536268944165947 0.294903756789604 no 2390 0.295886345349437 3380 2697450
SGTC_154 3389-1638 511.116 µM -0.536450594520967 0.29484124362291 no 2391 0.295823586206109 3356 5238686
SGTC_887 0885-0007 9.62 µM -0.537138029707609 0.294604724943905 no 2392 0.295586136713742 3437 5719458
SGTC_1497 4476-2978 41.3 µM -0.537811721036873 0.294373019931835 no 2393 0.295353519586774 3422 1528379
SGTC_2575 plumbagin 510 nM -0.537908902744025 0.294339602833325 no 2394 0.295319970920653 3329 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_672 1441-0018 53.7 µM -0.538100755330285 0.294273637157927 no 2395 0.295253745514709 3328 251141
SGTC_2120 5538279 151.968 µM -0.538210732219721 0.294235826309742 no 2396 0.295215785782778 3412 2058197
SGTC_1231 0242-0792 125 µM -0.539282434405836 0.293867484915472 no 2397 0.2948459936724 3368 3707635
SGTC_2655 perillic acid 100 µM -0.540058686761408 0.293600822162793 no 2398 0.294578280284579 3350 5702197 An apoptosis inducer.
SGTC_1256 0570-0116 285 µM -0.543099262455424 0.29255738623195 no 2399 0.293530730213504 3364 410638
SGTC_1429 4049-0205 9.46 µM -0.545302384934589 0.291802417845172 no 2400 0.292772782049575 3460 22774478
SGTC_237 nikkomycin 200 µM -0.546480918385439 0.291398929741995 no 2401 0.292367700386207 3481 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2826 7992541 19.48 µM -0.547389921507044 0.291087897201197 no 2402 0.292055438943551 3465 2985066
SGTC_3169 9102970 49.47 µM -0.547716946177479 0.290976037489585 no 2403 0.291943137165459 3459 17027839
SGTC_120 rhodamine 6G 52.259 µM -0.549426660072301 0.290391552276072 no 2404 0.291356341187185 3353 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_337 1315-0038 354 µM -0.550961892410685 0.289867184445543 no 2405 0.29082989899107 3392 1626437
SGTC_822 1487-0950 154 µM -0.551050775923284 0.289836839353223 no 2406 0.2907994338187 3463 1958375
SGTC_3210 9128157 49.47 µM -0.551358732181419 0.289731713709376 no 2407 0.290693892145934 3344 17590849
SGTC_951 1171-0579 82.7 µM -0.551884101253268 0.289552412141998 no 2408 0.290513880891295 3440 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_565 1418-0001 44.5 µM -0.552746760404337 0.289258110965537 no 2409 0.2902184145481 3495 2862145
SGTC_1450 4112-4260 37.6 µM -0.553159933143109 0.289117204501185 no 2410 0.290076950088135 3467 1633175
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.553280244043491 0.289076180313094 no 2411 0.290035763426302 3376 688667
SGTC_2785 7756463 72.73 µM -0.554053156994408 0.288812694059423 no 2412 0.289771233477694 3349 2201551
SGTC_2462 5162487 171.77 µM -0.555157626306854 0.288436376467515 no 2413 0.289393424733536 3437 2259986
SGTC_643 k048-0106 28.4 µM -0.556992650461168 0.287811653869232 no 2414 0.288766225332769 3461 6763920
SGTC_2336 9001819 198.65 µM -0.559007493864217 0.287126449969579 no 2415 0.288078302915623 3553 2989602
SGTC_3130 9127414 49.47 µM -0.559355990879815 0.287008012196817 no 2416 0.287959395042313 3448 1494646
SGTC_1004 4084-0029 199 µM -0.56169277750702 0.286214446532218 no 2417 0.287162678032511 3475 716894 YLR208W SEC13
SGTC_428 3448-4153 16.5 µM -0.563992532180179 0.285434475687594 no 2418 0.286379607226085 3320 3834874
SGTC_1687 st020778 55.3625 µM -0.56450007379338 0.285262477380322 no 2419 0.286206924973013 3456 4259299
SGTC_3078 9116413 49.47 µM -0.565681912986212 0.284862161125434 no 2420 0.285805016391409 3387 17177322
SGTC_187 1488-2104 32.728 µM -0.566543690088052 0.284570426369245 no 2421 0.285512120786465 3454 2852859
SGTC_974 1326-0144 138 µM -0.568486297403329 0.283913325294759 no 2422 0.284852403722059 3421 5411856
SGTC_38 0929-0051 58.268 µM -0.568930201638675 0.283763273445125 no 2423 0.284701754247505 3435 1379719
SGTC_2803 7707263 71.43 µM -0.569618991918701 0.283530518574974 no 2424 0.284468072178577 3386 2199229
SGTC_1143 3454-2408 5.08 µM -0.56964567455728 0.283521503862955 no 2425 0.284459021551165 3457 X1143
SGTC_2592 piperlongumine 83.33 µM -0.570116884610524 0.283362328489338 no 2426 0.284299211953556 3404 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_219 mitoxanthrone 164.414 µM -0.572615685860705 0.282518947004065 no 2427 0.283452468321224 3431 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1388 3346-4487 254 µM -0.573659529703239 0.28216699239216 no 2428 0.283099109773025 3468 3345614
SGTC_2302 7771753 200 µM -0.573774419108118 0.282128267832373 no 2429 0.283060230711095 3447 2203047
SGTC_2038 4100038 30.985 µM -0.577416258947883 0.280902079185459 no 2430 0.281829146683442 3470 3596803
SGTC_2733 amorolfine 100 µM -0.577673357181248 0.280815612980983 no 2431 0.281742335044215 3472 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1229 0139-0193 12.2 µM -0.577848435967788 0.280756738581059 no 2432 0.28168322542218 3519 3090752
SGTC_2861 9024595 19.48 µM -0.578034902766628 0.280694041256622 no 2433 0.281620277586385 3400 16482810
SGTC_1288 0973-0013 65.5 µM -0.578191032338917 0.280641549686875 no 2434 0.281567576270816 3497 4315430
SGTC_3353 9151644 39.2805 µM -0.578456272219696 0.28055238555543 no 2435 0.281478055831767 3493 4909158
SGTC_2880 9042983 58.44 µM -0.578742705939895 0.280456112214262 no 2436 0.281381397737883 3499 6464714
SGTC_1298 1079-1278 263 µM -0.579568374600352 0.280178685949565 no 2437 0.281102862540439 3483 2840950
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.581053548014179 0.279679999761605 no 2438 0.280602182216559 3472 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_290 2043-6722 48.1 µM -0.583426957815606 0.278883960108308 no 2439 0.279802957310556 3491 773758 YLR208W SEC13
SGTC_2929 9013348 24.6 µM -0.58427239413486 0.278600668003352 no 2440 0.279518531037777 3460 2995952
SGTC_1344 1488-0097 29.1 µM -0.584462217579091 0.27853708049325 no 2441 0.279454688909453 3494 747966
SGTC_1730 st033808 45.1 µM -0.584466368869891 0.278535689962953 no 2442 0.27945329281099 3387 1045166
SGTC_2979 9012552 45.46 µM -0.586132685253758 0.277977808293123 no 2443 0.278893176571042 3567 17100905
SGTC_2068 5226020 147 µM -0.58614750286966 0.277972849811675 no 2444 0.278888198223094 3471 1810509
SGTC_1982 st072467 71.9 µM -0.586359949020177 0.27790176280429 no 2445 0.278816826390011 3376 3163533
SGTC_296 1222-0039 74.9 µM -0.587384262126301 0.277559140048812 no 2446 0.278472830561614 3452 5984176
SGTC_2963 9082507 9 µM -0.588140975103031 0.277306159568951 no 2447 0.278218835956795 3503 16459611
SGTC_3227 9130768 49.47 µM -0.58888213579814 0.277058487810081 no 2448 0.277970171110579 3497 17720899
SGTC_1198 1612-1005 86.7 µM -0.589753955200425 0.276767292812893 no 2449 0.277677808203885 3575 6998509
SGTC_3198 9112019 49.47 µM -0.590508560724851 0.27651536934405 no 2450 0.277424874066316 3497 45595555
SGTC_548 1436-0017 110 µM -0.591262797527016 0.276263681368554 no 2451 0.277172176119747 3571 9677137
SGTC_2711 st079103 59.1 µM -0.592927285215578 0.275708641769142 no 2452 0.27661490839275 3454 54693780
SGTC_1975 st070967 30.8 µM -0.593986972304484 0.275355564605814 no 2453 0.276260413230559 3536 261391
SGTC_1424 4048-1941 275 µM -0.596252649887468 0.274601410686871 no 2454 0.275503228933694 3561 X1424
SGTC_86 0417-1630 471.922 µM -0.59646688356767 0.274530153577971 no 2455 0.275431685383157 3542 3634867
SGTC_1416 3966-0321 25.3 µM -0.599775400669793 0.273430854462277 no 2456 0.274327964815129 3495 582530 YLR208W SEC13
SGTC_3079 9117512 49.47 µM -0.600931470372371 0.273047249280794 no 2457 0.273942815669248 3544 7185044
SGTC_1809 st050081 57.6 µM -0.601243966771698 0.272943603050205 no 2458 0.273838752179789 3590 5036894
SGTC_1365 1672-3266 55.4 µM -0.601333509719435 0.272913907779456 no 2459 0.273808937354391 3529 6415873
SGTC_502 l-744,832 89.3 µM -0.602290344033651 0.272596691353283 no 2460 0.273490443591879 3506 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1677 st019204 53.9 µM -0.602409698844924 0.272557134851644 no 2461 0.273450727781428 3487 3945625
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.602581344972979 0.27250025298878 no 2462 0.273393616823753 3548 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3151 9099821 49.47 µM -0.603386413819186 0.272233539662518 no 2463 0.27312582913318 3494 17174189
SGTC_2337 9009472 200 µM -0.604075294660754 0.272005421602576 no 2464 0.272896791965633 3583 5742383
SGTC_1243 0416-0003 5.65 µM -0.605274566066043 0.271608518221602 no 2465 0.272498288963337 3461 2141977
SGTC_2959 9079155 11 µM -0.606746839955343 0.271121658283042 no 2466 0.27200946605578 3537 16189457
SGTC_834 0312-0008 75.7 µM -0.607295159934355 0.2709404479879 no 2467 0.271827524915167 3538 6385573 YIL048W NEO1
SGTC_3263 9137018 49.47 µM -0.607576280597942 0.270847565897369 no 2468 0.271734268171641 3493 43844957
SGTC_370 0180-0345 38.7 µM -0.608131771793041 0.27066407869499 no 2469 0.271550040754225 3463 3989527
SGTC_1122 capsaicin 818.572 nM -0.608933552082946 0.270399347961421 no 2470 0.27128424183844 3541 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1911 st060208 74.3 µM -0.609029723825826 0.270367602799609 no 2471 0.27125236856835 3510 688783
SGTC_1900 st060200 72.8 µM -0.610129971376195 0.270004556636523 no 2472 0.270887857061776 3530 688945
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.610764262801822 0.269795371859847 no 2473 0.270677827744805 3552 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2639 lactacystin 53 µM -0.612706039816324 0.269155492580001 no 2474 0.270035364094054 3559 3870 A proteasome inhibitor.
SGTC_401 neomycin 50 µM -0.612728384452233 0.269148133722537 no 2475 0.270027975506673 3486 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_48 0382-0018 55 µM -0.619882831805541 0.266797131044717 no 2476 0.267667464760198 3668 762596
SGTC_570 0987-0065 62.6 µM -0.622549288542589 0.265923576496419 no 2477 0.266790372318581 3442 3104428
SGTC_52 0329-0193 875 nM -0.623671306002511 0.265556427455038 no 2478 0.266421735524723 3622 3739292
SGTC_2362 9071156 126 µM -0.625316496711387 0.26501854980937 no 2479 0.265881677454886 3576 653133
SGTC_1961 st076550 68.7 µM -0.625503679573651 0.264957387447947 no 2480 0.265820267092535 3543 1579337
SGTC_1412 3909-8563 178 µM -0.625534015282941 0.264947475871869 no 2481 0.265810315325812 3621 23767530
SGTC_1672 st016598 6.51 µM -0.626000551084652 0.264795068520919 no 2482 0.2656572899324 3494 4665860 YNL267W PIK1
SGTC_3138 9097216 49.47 µM -0.626196311526862 0.264731131014321 no 2483 0.265593093122396 3582 25237486
SGTC_1048 3161-0300 24.5 µM -0.626654076197416 0.264581650702555 no 2484 0.265443006526717 3565 2165101
SGTC_1325 1431-0015 227 µM -0.627836620279766 0.264195696851843 no 2485 0.265055486911811 3493 1103340
SGTC_558 k064-0027 21.3 µM -0.62815113940996 0.264093093694089 no 2486 0.264952467420191 3548 5088526
SGTC_2027 5150920 200 µM -0.629548839463224 0.263637378447677 no 2487 0.264494902576929 3527 786715
SGTC_2242 6630449 61.2675 µM -0.630353765267904 0.263375117351675 no 2488 0.264231576728183 3549 691249 YDR170C SEC7
SGTC_1397 3532-0190 20.1 µM -0.632358863623105 0.262722395467108 no 2489 0.263576203844539 3493 5322280
SGTC_165 k038-0023 64.381 µM -0.632770937502877 0.262588355182831 no 2490 0.263441618983262 3547 46368543
SGTC_1254 0550-0035 264 µM -0.634337459847687 0.262079113010989 no 2491 0.262930307316989 3586 15121435
SGTC_2837 9008476 45.46 µM -0.634611774281304 0.261989991491705 no 2492 0.262840823529682 3592 2992805
SGTC_2293 7624732 200 µM -0.634928875445566 0.261886988433813 no 2493 0.262737401743832 3551 894453
SGTC_2476 5806916 10.51 µM -0.635233924409963 0.261787919859607 no 2494 0.262637930402591 3515 2870194
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.637822879760913 0.260947897949471 no 2495 0.261794492035489 3595 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2770 toltrazuril 17.5 µM -0.637960869175947 0.260903164340245 no 2496 0.261749576424216 3574 68591 Kills coccidiodes.
SGTC_1876 myriocin 605 nM -0.638989052013448 0.260569970758588 no 2497 0.261415027011179 3606 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2237 6667747 47.222 µM -0.639189454917246 0.26050505358597 no 2498 0.261349845634918 3476 729940 YDL015C TSC13
SGTC_504 lovastatin 124 µM -0.640286746630339 0.260149751961468 no 2499 0.260993097737635 3532 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1057 3448-5381 134 µM -0.641885202024839 0.259632621522594 no 2500 0.26047386155386 3594 5497911
SGTC_2626 ethyl orsellinate 100 µM -0.642368987736928 0.259476212406204 no 2501 0.260316815370576 3575 75653 A natural product.
SGTC_2219 9098279 200 µM -0.647015303857645 0.257976528802442 no 2502 0.258811019413945 3580 902349
SGTC_2724 maprotiline 69.64 µM -0.647498567856166 0.257820805045616 no 2503 0.258654660549923 3578 4011 A tricyclic antidepressant.
SGTC_507 nimesulide 162 µM -0.648132353551667 0.257616652150348 no 2504 0.258449674915828 3639 4495 A COX2 inhibitor.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.648244002114115 0.257580696993024 no 2505 0.258413573083818 3610 16623 A steroid.
SGTC_1294 1000-1494 117 µM -0.648511372589017 0.257494603948707 no 2506 0.258327128816706 3572 712797 YDL207W GLE1
SGTC_3175 9106517 49.47 µM -0.648975338264546 0.257345242915086 no 2507 0.258177158398103 3574 41468073
SGTC_826 1683-5028 118 µM -0.651306661440389 0.256595419384692 no 2508 0.257424274561672 3599 722377
SGTC_2971 9092186 9.93 µM -0.651793785122643 0.256438889618784 no 2509 0.257267105716742 3518 25236400
SGTC_2741 miltefosine 3.04 µM -0.651873387911583 0.256413315206905 no 2510 0.257241426882466 3505 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_103 0844-0104 51.839 µM -0.652255240182174 0.256290653975796 no 2511 0.257118264787124 3632 5375804
SGTC_3203 9113543 49.47 µM -0.65273120353947 0.256137804563785 no 2512 0.256964791177207 3611 17018012
SGTC_2377 9073351 62.6 µM -0.653385755473539 0.255927681430796 no 2513 0.256753809836023 3558 7337946 YHR072W ERG7
SGTC_94 0334-0113 514.748 µM -0.653952661765069 0.255745766864557 no 2514 0.256571152163076 3549 6795178
SGTC_2197 6588183 93.1375 µM -0.654022841859877 0.255723251469934 no 2515 0.256548544787679 3588 884136
SGTC_1558 st069300 45.6 µM -0.654190343835971 0.25566951715215 no 2516 0.25649459094599 3557 24208000
SGTC_200 k038-0079 37.545 µM -0.655249460037696 0.255329891227607 no 2517 0.256153577321002 3564 3436683
SGTC_3306 9127676 59.7925 µM -0.657053061896275 0.254752074883059 no 2518 0.255573399219473 3585 41905287
SGTC_1873 rapamycin 2 nM -0.659076998420851 0.254104486474276 no 2519 0.254923162652017 3606 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2834 9001755 58.44 µM -0.65983029369206 0.253863679204304 no 2520 0.254681370332192 3528 2989575
SGTC_2106 5357045 167.29 µM -0.660061817693018 0.253789691578187 no 2521 0.254607080015853 3611 668842
SGTC_2933 9026794 32.47 µM -0.661913999277413 0.253198201689392 no 2522 0.254013169692694 3608 17586027
SGTC_518 1021-0119 62.6 µM -0.663088702407121 0.252823439014272 no 2523 0.253636872907754 3552 1097762
SGTC_1275 0867-0008 21.1 µM -0.664131311721299 0.252491062674744 no 2524 0.253303135617747 3577 3422836
SGTC_2848 9016370 25.97 µM -0.664367585645759 0.252415772264116 no 2525 0.253227536876774 3636 7894410
SGTC_1691 st019933 84.6 µM -0.665137311041374 0.252170575736858 no 2526 0.252981336100591 3604 6176082
SGTC_771 0250-0039 27.3 µM -0.666858972581576 0.251622594384687 no 2527 0.252431109744061 3607 3005115
SGTC_1118 chelidonine 707.474 nM -0.669527994483358 0.250774326185642 no 2528 0.2515793645687 3644 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1221 2958-7315 257 µM -0.670943445237788 0.250325082998404 no 2529 0.251128279125448 3641 4562705
SGTC_1801 st050089 28.441 µM -0.671169394669193 0.250253409492779 no 2530 0.251056311647224 3651 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3320 9137005 35.139 µM -0.6715749585033 0.250124787734057 no 2531 0.250927162302576 3602 4908713
SGTC_2565 isoliquiritigenin 100 µM -0.673479100530316 0.249521371403333 no 2532 0.25032127022044 3584 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_766 1391-0721 126 µM -0.673646932317408 0.249468223180032 no 2533 0.250267903885886 3636 1020919 YIL115C NUP159
SGTC_203 k066-0004 30.888 µM -0.674525797938414 0.249190006191719 no 2534 0.249988545011249 3696 6795412
SGTC_949 1165-0505 146 µM -0.678757793549879 0.247852623502066 no 2535 0.248645670250409 3664 6244267
SGTC_970 1315-0089 19.5 µM -0.678798790346537 0.247839686580503 no 2536 0.248632680177864 3593 6811083 YLR033W RSC58
SGTC_2023 5144124 124 µM -0.680634423857497 0.247260804889088 no 2537 0.248051419692098 3637 2830192
SGTC_1901 st060216 58.6 µM -0.681453530410741 0.247002726555853 no 2538 0.247792280541236 3653 688792
SGTC_1089 terbinafine 2.25 µM -0.683633669784593 0.246316526471648 no 2539 0.247103258979551 3636 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_941 3237-0776 460 µM -0.684961959866953 0.245898947945562 no 2540 0.246683962851544 3654 760008
SGTC_2576 guaiol 23.12 µM -0.684976384190541 0.245894415413996 no 2541 0.246679411673988 3657 227829
SGTC_2717 st081029 62.2815 µM -0.686458748922832 0.245428853540504 no 2542 0.246211934271105 3633 5292846
SGTC_67 0335-0847 266 µM -0.68694474366207 0.245276321788287 no 2543 0.24605877480869 3731 4552207 YOR254C SEC63
SGTC_2506 ethyl hematommate 54.16 µM -0.687150340630494 0.245211809548379 no 2544 0.245993997064421 3648 3940691 An allergen.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.687429201752124 0.245124323055501 no 2545 0.24590615049739 3670 5379071
SGTC_1912 st060209 90.8 µM -0.687622345551399 0.245063738312954 no 2546 0.245845316390109 3649 688787
SGTC_333 3486-0131 40.1 µM -0.68814442787934 0.244900013481767 no 2547 0.245680917624232 3721 6744690
SGTC_2067 5224629 34.075 µM -0.689507241392599 0.244472913166294 no 2548 0.245252058916343 3642 2835000
SGTC_891 0929-0073 133 µM -0.691808900961899 0.243752494402914 no 2549 0.244528673066063 3677 5603632
SGTC_1658 st012944 20 µM -0.69230576358701 0.243597127082135 no 2550 0.244372665677998 3605 24207260
SGTC_2290 7904846 200 µM -0.6927827211544 0.243448034332523 no 2551 0.24422295865147 3708 2962154
SGTC_965 1291-5240 308 µM -0.693071318553422 0.243357845264053 no 2552 0.244132397967104 3645 2834598
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.693344229589327 0.243272574926418 no 2553 0.244046776261389 3675 6708739 YPR165W RHO1
SGTC_1552 6-methylflavone 10.6 µM -0.694544088048198 0.24289787395269 no 2554 0.243670531058647 3630 689013
SGTC_1258 0671-0043 57.1 µM -0.695187315776438 0.242697130524783 no 2555 0.243468960172302 3659 4298767
SGTC_584 0986-0246 15.4 µM -0.695567628735785 0.242578481811922 no 2556 0.243349822344441 3756 53315 YDR232W HEM1
SGTC_1688 st021091 57.6 µM -0.69620663871889 0.24237919645063 no 2557 0.243149715372384 3676 3656366
SGTC_2322 7413319 38.22 µM -0.696284867244241 0.242354805744733 no 2558 0.243125224101889 3712 1840400
SGTC_1884 5633444 25 µM -0.696409399383761 0.242315980877135 no 2559 0.243086239153505 3683 5724239
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.696838857831822 0.242182116259403 no 2560 0.242951822562372 3495 4000243
SGTC_351 caspofungin 25 nM -0.697531378992324 0.241966337985255 no 2561 0.242735154458787 3710 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2752 diclazuril 33.15 µM -0.698338900207466 0.241714859326957 no 2562 0.24248263860079 3718 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2804 7954240 19.48 µM -0.698508289722966 0.241662125965958 no 2563 0.242429687725866 3674 828705
SGTC_1501 4491-0275 38.4 µM -0.699240406149016 0.241434279575388 no 2564 0.242200901436968 3663 5104718
SGTC_2533 agelasine 13.65 µM -0.701354593392885 0.240776966086351 no 2565 0.241540875710628 3706 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2682 pyrogallin 40.03 µM -0.701532493758629 0.240721700248574 no 2566 0.241485381783465 3709 822798 An ATP competetive kinase inhibitor.
SGTC_3322 9139058 2.11 µM -0.702735529626701 0.240348151050921 no 2567 0.241110290701363 3742 4908926 YPR165W RHO1
SGTC_468 gf-109203x 121 µM -0.70289247578387 0.240299441709837 no 2568 0.241061380279312 3616 2396 A protein kinase C inhibitor.
SGTC_1613 st002381 52.1 µM -0.703647740052056 0.240065115380026 no 2569 0.240826086526728 3679 551167
SGTC_1714 st033236 13.627 µM -0.704098461797693 0.239925334998987 no 2570 0.24068572899454 3710 2916566
SGTC_884 0851-0618 334 µM -0.704766099877498 0.239718364893904 no 2571 0.240477904225456 3699 9642473
SGTC_1738 st035555 74 µM -0.704984738069456 0.239650607484222 no 2572 0.240409866995157 3696 5331140
SGTC_1029 k015-0030 64.7 µM -0.705679063485139 0.239435500806297 no 2573 0.240193871908415 3737 2208316
SGTC_1656 st012921 11 µM -0.706023895079068 0.239328708860884 no 2574 0.240086638861647 3629 6732821
SGTC_3340 9146634 11.102 µM -0.706525175068294 0.239173512349975 no 2575 0.239930801266564 3693 4907387
SGTC_2969 9091408 28.7 µM -0.706653504694979 0.239133790283419 no 2576 0.239890915107182 3659 4286311
SGTC_1834 st055981 52.8 µM -0.708225966592738 0.238647356618627 no 2577 0.239402471666353 3724 471719 YDL150W RPC53
SGTC_2350 9023895 38.85 µM -0.708239902010633 0.238643048184852 no 2578 0.239398145429091 3694 2997209
SGTC_814 3342-0569 96 µM -0.711823529349276 0.23753650693595 no 2579 0.238287030231635 3729 4346283
SGTC_984 1492-0255 2.91 µM -0.714340631405603 0.236760970762427 no 2580 0.237508286631855 3648 1585198
SGTC_2681 menadione 3.18 µM -0.714963955562396 0.236569135715354 no 2581 0.237315657988454 3719 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2751 anetholtrithion 17.25 µM -0.715112845001894 0.236523325966884 no 2582 0.237269658718623 3687 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3223 9129970 49.47 µM -0.715564893820771 0.236384271183896 no 2583 0.237130028617112 3741 17248386
SGTC_3066 9117245 49.47 µM -0.716486918447491 0.236100786658275 no 2584 0.236845371079959 3766 17176980
SGTC_2193 5925765 200 µM -0.718306094735332 0.235542014741188 no 2585 0.236284286525818 3693 877370
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.718368353191126 0.235522904569282 no 2586 0.236265097248592 3680 61125 An anti-inflammatory.
SGTC_2443 5493264 126.67 µM -0.718674098994577 0.235429068612187 no 2587 0.236170872851759 3726 5340055
SGTC_3017 9080681 49.47 µM -0.719954763543459 0.23503624619257 no 2588 0.235776424106202 3716 16451914
SGTC_1886 st057356 49.9 µM -0.72106921371715 0.234694702110544 no 2589 0.235433465717683 3698 24207747
SGTC_768 0384-0033 77.3 µM -0.722390327787109 0.234290177747017 no 2590 0.23502726591923 3699 3965305 YMR134W ERG29
SGTC_2139 5578692 56.4705 µM -0.723144950023932 0.234059286150274 no 2591 0.234795417869044 3648 650991 YMR113W FOL3
SGTC_1524 corynanthine 62.1 µM -0.723654714839475 0.233903384871477 no 2592 0.234638870713775 3788 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_220 paclitaxel 373.376 µM -0.723852302011892 0.233842972299361 no 2593 0.234578207846942 3661 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_803 4488-1585 147 µM -0.724634655111402 0.233603851594438 no 2594 0.23433809636608 3694 747204
SGTC_2277 7947813 106.88 µM -0.725502741440921 0.23333868589337 no 2595 0.234071831830042 3768 1246798
SGTC_1088 bifonazole 369 nM -0.726222659749436 0.2331189063515 no 2596 0.233851141417388 3657 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2133 5320837 200 µM -0.726396516256781 0.233065847975247 no 2597 0.233797863126598 3686 2841355
SGTC_2129 girgensonine 121.053 µM -0.727769112231413 0.232647187981316 no 2598 0.23337746767563 3776 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2869 9037858 32.47 µM -0.728748102285763 0.23234883861175 no 2599 0.233077881342961 3681 27187042
SGTC_2184 6075246 200 µM -0.730472555941987 0.231823825601875 no 2600 0.23255069116579 3772 2267320
SGTC_1500 4488-1866 171 µM -0.73202802177244 0.231350828651947 no 2601 0.232075732264549 3798 2900003
SGTC_2271 7849410 118.62 µM -0.732705126442417 0.23114509818516 no 2602 0.231869148302013 3689 972430
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.733080850536083 0.231030982795766 no 2603 0.231754559455019 3774 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2327 6189656 200 µM -0.733082251892296 0.231030557232984 no 2604 0.231754132126554 3781 5349088
SGTC_2158 5657123 3.6195 µM -0.733231145065259 0.230985343961231 no 2605 0.231708731260409 3713 2858827
SGTC_1289 0976-0073 69.1 µM -0.733474240123209 0.230911535727393 no 2606 0.231634616779906 3765 3391136
SGTC_1168 k815-0004 80.5 µM -0.735809688981601 0.230203120844732 no 2607 0.23092326196885 3715 642433
SGTC_2143 5623677 140.463 µM -0.736234808129723 0.230074299784678 no 2608 0.23079390619225 3692 5375313
SGTC_205 1486-1330 71.903 µM -0.737535728422603 0.229680341146865 no 2609 0.230398312088183 3718 4118834
SGTC_129 0088-0017 176.636 µM -0.739037378002858 0.229226065662921 no 2610 0.22994215036181 3627 182446
SGTC_334 1502-1024 68.5 µM -0.739333099647948 0.229136664065621 no 2611 0.229852377503811 3768 3296216
SGTC_727 3032-0951 202 µM -0.740913899571613 0.228659093646619 no 2612 0.229372823601743 3728 3652836
SGTC_2429 5902844 64.44 µM -0.741852533812189 0.228375790534899 no 2613 0.22908834364609 3779 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2616 abietic acid 100 µM -0.743942417757522 0.22774572073889 no 2614 0.22845565598729 3734 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_536 3852-0578 10.6 µM -0.744624355917388 0.227540338154599 no 2615 0.22824941990209 3743 2869208
SGTC_2318 6029776 164 µM -0.746987661184556 0.226829377835926 no 2616 0.227535504466737 3739 818325
SGTC_2078 5212016 200 µM -0.750378938502813 0.225811362397395 no 2617 0.226513256025998 3669 1899708
SGTC_2409 alverine citrate 63.97 µM -0.751141411285814 0.225582834734768 no 2618 0.226283777868759 3928 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_276 colchicine 750 µM -0.752539385405818 0.225164175337252 no 2619 0.225863376939437 3789 2833 A microtubule depolymerizer.
SGTC_3084 9116877 49.47 µM -0.753158442284329 0.224978923498215 no 2620 0.225677354395089 3666 27241325
SGTC_2643 anethole 100 µM -0.754606573948556 0.224545909830479 no 2621 0.225242539023353 3764 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1945 st075991 56.6 µM -0.75475001373057 0.224503044879942 no 2622 0.225199495700684 3735 1084980
SGTC_3328 9140624 29.0385 µM -0.755570984516755 0.224257798724899 no 2623 0.224953228952512 3760 4904392
SGTC_216 k038-0035 28.382 µM -0.755977850324595 0.224136313309484 no 2624 0.224831237936908 3679 4444231 YPR107C YTH1
SGTC_3124 9127567 49.47 µM -0.756452595371599 0.223994607202492 no 2625 0.224688942043224 3708 17592030
SGTC_918 glabranin 770.725 nM -0.757466266167407 0.223692208197619 no 2626 0.224385284327766 3797 124049 Also referred to as licorice root.
SGTC_44 0929-0055 61.211 µM -0.759133936445879 0.22319521301116 no 2627 0.223886220108034 3729 1379590
SGTC_213 1246-0773 967 nM -0.759345752519507 0.223132133102751 no 2628 0.223822877563295 3744 6251622
SGTC_1119 parthenolide 318.541 nM -0.759387741163854 0.223119629875643 no 2629 0.223810322277602 3905 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_939 1165-0479 45.3 µM -0.760388296799381 0.222821806060689 no 2630 0.223511258363922 3710 1377347
SGTC_2236 dapsone 200 µM -0.761051711221117 0.222624460119128 no 2631 0.223313090620265 3779 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_861 0443-0273 110 µM -0.761454558604165 0.222504673713598 no 2632 0.223192805360758 3806 6149169
SGTC_2273 7815444 169.05 µM -0.762120401064723 0.222306766493281 no 2633 0.222994073899265 3712 2824616
SGTC_916 4466-0038 42 nM -0.762811946620587 0.222101325943985 no 2634 0.222787777667515 3856 5722064 YGL116W CDC20
SGTC_3232 9132874 49.47 µM -0.762955526211918 0.22205868569853 no 2635 0.222744959812295 3765 3784940
SGTC_3100 9120536 49.47 µM -0.763091229503684 0.222018388851439 no 2636 0.222704495113751 3640 16421196
SGTC_2587 piperic acid 92.2 µM -0.763472663858692 0.221905144971854 no 2637 0.222590779517179 3787 5370536
SGTC_2206 7254556 146.969 µM -0.764183202370721 0.221694281483001 no 2638 0.222379037623028 3788 4398905
SGTC_1969 st069479 40.1 µM -0.764924987785738 0.221474267184028 no 2639 0.222158106724038 3759 3895485
SGTC_197 4544-0043 41.561 µM -0.765214131119221 0.22138854080359 no 2640 0.222072023178992 3773 896523
SGTC_2700 st077718 96.8 µM -0.765751526541956 0.221229262056719 no 2641 0.221912080793467 3785 904970
SGTC_2642 cholecalciferol 100 µM -0.7660463171368 0.221141916856705 no 2642 0.221824371650882 3755 9821465 A vitamin D precursor, similar to steriods.
SGTC_69 0096-0274 206.684 µM -0.76609338364819 0.221127973076302 no 2643 0.221810369769623 3876 6741392
SGTC_2208 7283366 200 µM -0.766506461820725 0.221005617386715 no 2644 0.221687504236237 3755 898663
SGTC_12 0849-0099 9.267 µM -0.767087914659923 0.220833454009016 no 2645 0.221514623432078 3693 6071388
SGTC_1924 st058459 75.1 µM -0.767834643692171 0.220612466393738 no 2646 0.221292714867057 3722 688683
SGTC_133 0724-0033 378.92 µM -0.768156982280898 0.220517112403045 no 2647 0.221196963472597 3655 280309
SGTC_2640 pentamidine 10.38 µM -0.770296247053892 0.219884875273834 no 2648 0.220562091042296 3811 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3229 9132204 49.47 µM -0.771420003357664 0.219553178158911 no 2649 0.22022901110397 3792 17682924
SGTC_231 b-estradiol 524 µM -0.773543796424827 0.218927087467951 no 2650 0.219600309843805 3733 450 A steroid.
SGTC_357 1325-0123 420 µM -0.774062942076631 0.218774200543376 no 2651 0.219446785350736 3797 1098503
SGTC_671 0560-0003 407 µM -0.77481871265009 0.218551738115488 no 2652 0.219223395151313 3729 3238678
SGTC_373 0844-0104 25.9 µM -0.776049162960078 0.218189831637669 no 2653 0.218859979206142 3845 5375804
SGTC_1112 tnp00069 1.16933 µM -0.776308283871728 0.218113661686384 no 2654 0.218783491535983 3842 145826
SGTC_3310 9130229 44.1445 µM -0.776683702318001 0.218003332657425 no 2655 0.21867270229003 3882 7761258
SGTC_2561 acetosyringone 100 µM -0.777241197097363 0.217839553904525 no 2656 0.218508240333453 3806 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2735 sertaconazole 140 nM -0.777718913836429 0.217699268525487 no 2657 0.218367369724023 3864 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.778334406583631 0.217518600971237 no 2658 0.21818594843678 3798 688662
SGTC_1347 1493-0251 600 nM -0.779142759857242 0.217281453969278 no 2659 0.217947812005914 3836 3986378
SGTC_1645 Cervolide 78 µM -0.779147007149137 0.217280208333616 no 2660 0.217946561172988 3780 23173 A fragrance.
SGTC_2190 6049624 200 µM -0.779772619687734 0.217096775225243 no 2661 0.217762362689362 3693 2265554
SGTC_2200 6600604 21.907 µM -0.782993023098015 0.216153951732711 no 2662 0.216815604558326 3764 2904777
SGTC_3038 9091290 49.47 µM -0.783503091868259 0.216004838944509 no 2663 0.216665869378937 3807 25236843
SGTC_2739 tacrine 100.86 µM -0.785572271202294 0.215400549492581 no 2664 0.216059057355371 3822 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_862 0452-0056 10.2 µM -0.786107585341923 0.215244374552936 no 2665 0.21590223039767 3755 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2255 7941087 197.44 µM -0.786933743389236 0.215003476531021 no 2666 0.21566032658617 3815 935561
SGTC_726 3448-4391 34.2 µM -0.787142817444945 0.214942537815198 no 2667 0.215599133429667 3872 1356692
SGTC_2401 5128683 200 µM -0.787270733562472 0.214905259111796 no 2668 0.215561699072255 3793 708373
SGTC_1214 0358-0031 63.7 µM -0.788177608015179 0.214641075625584 no 2669 0.215296412462094 3955 4301366
SGTC_1892 st058411 7.36 µM -0.788702033947717 0.214488390189199 no 2670 0.21514308943418 3804 3934738
SGTC_2086 5274770 176.623 µM -0.788978671254091 0.214407873304985 no 2671 0.215062236312212 3867 689278
SGTC_493 zm226600 134 µM -0.789821134798669 0.214162777725733 no 2672 0.21481611716844 3813 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3163 9099914 49.47 µM -0.792002333841903 0.213528965506265 no 2673 0.214179657703776 3829 16268368
SGTC_1914 st062367 72.6 µM -0.792303765158127 0.213441461725553 no 2674 0.214091788409168 3838 978205
SGTC_3335 9143315 29.6265 µM -0.794112850501673 0.21291673395294 no 2675 0.213564868602263 3820 4899691
SGTC_2466 5983409 37.09 µM -0.79425934729441 0.212874275325234 no 2676 0.213522232591373 3832 2879657
SGTC_1031 k035-0009 16 µM -0.795932455377156 0.212389715159835 no 2677 0.21303564789449 3911 5180959
SGTC_2664 lyso-paf C-16 73.48 µM -0.798565659674338 0.211628401812864 no 2678 0.212271153204839 3810 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3180 9109287 49.47 µM -0.80007667378022 0.211192258935925 no 2679 0.21183318751818 3869 18891271
SGTC_2651 TUB2.036 5 µM -0.800913935866825 0.210950816468738 no 2680 0.211590735885546 3884 15992207 YFL037W TUB2
SGTC_836 0330-0104 1.35 µM -0.801344035753283 0.210826850893769 no 2681 0.211466252144436 3830 46494820
SGTC_1054 3429-0080 167 µM -0.801929132977982 0.210658279808748 no 2682 0.211296976421103 3827 1162877
SGTC_3063 1327-0034 4 µM -0.804472255616075 0.209926505687838 no 2683 0.210562143111732 3720 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2020 4017018 200 µM -0.804745401425903 0.209847997937376 no 2684 0.210483307128174 3924 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2 0422-0095 29 µM -0.805837587750474 0.209534253533854 no 2685 0.210168250932354 3699 6790840
SGTC_3243 9134147 49.47 µM -0.809134454804662 0.20858886173407 no 2686 0.209218905820518 3886 24282180
SGTC_2276 7947513 42.08 µM -0.809556310960216 0.208468074275438 no 2687 0.209097613211563 3747 2105100
SGTC_1201 1889-3372 45.9 µM -0.811137900243474 0.208015594963509 no 2688 0.208643241454475 3743 5392199
SGTC_295 k015-0027 31 µM -0.811204116736341 0.20799666363839 no 2689 0.208624230947346 3834 3887424
SGTC_41 0478-0632 82.643 µM -0.814379105544559 0.207090127080845 no 2690 0.207713902369376 3787 3750424
SGTC_1105 epirubicin 18.1 µM -0.816216517262811 0.206566570805908 no 2691 0.207188155771045 3858 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2756 carbadox 75.1 µM -0.817567634624071 0.206182081050637 no 2692 0.206802057350015 3866 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1717 st033143 58.0435 µM -0.81866915414629 0.205868933947596 no 2693 0.20648759999027 3846 674616
SGTC_2600 tangeritin 87.95 µM -0.819542187044831 0.205620943056686 no 2694 0.206238571415961 3815 68077 A bioactive flavone.
SGTC_650 1328-0195 38 µM -0.821971051067227 0.204931941410141 no 2695 0.205546686511156 3788 2780821
SGTC_3276 9139060 49.47 µM -0.82449323859228 0.204217921218307 no 2696 0.204829678030372 3938 4870619
SGTC_903 1134-0042 114 µM -0.824619501622451 0.204182215692256 no 2697 0.204793823062369 3868 701009
SGTC_1946 st076057 65.1 µM -0.828100767446456 0.203199224613925 no 2698 0.203806717467057 3750 953009
SGTC_73 0327-0325 16.231 µM -0.829709923554059 0.202745809908971 no 2699 0.203351404710016 3820 53298
SGTC_2420 aureobasidin a 50 nM -0.830220528392024 0.202602062342452 no 2700 0.203207055374174 4012 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_777 1315-0167 517 µM -0.83142180696673 0.20226411381175 no 2701 0.202867692048938 3930 4221767
SGTC_865 0488-0499 301 µM -0.83145673767406 0.202254292012075 no 2702 0.202857829130193 3827 9634651
SGTC_1356 1502-0781 85.8 µM -0.832850113684665 0.201862735922726 no 2703 0.202464633747234 3834 567702
SGTC_749 1000-0129 128 µM -0.833893403204899 0.201569855864199 no 2704 0.202170527463987 3940 708470
SGTC_610 4215-0184 155 µM -0.834081385297024 0.201517111202893 no 2705 0.202117561967965 3899 5605015
SGTC_2489 cantharidin 73.42 µM -0.83414141814017 0.201500268723841 no 2706 0.20210064897147 3834 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1286 0929-0070 131 µM -0.834275609838933 0.201462623700731 no 2707 0.202062846332675 3980 1420408
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.835841871522211 0.201023549425844 no 2708 0.201621933652703 3883 6857784
SGTC_3249 9135183 49.47 µM -0.836906847861923 0.200725329907168 no 2709 0.201322465439369 3897 4902779
SGTC_966 1300-0360 30.2 µM -0.840107771262027 0.199830592722162 no 2710 0.200423981621731 3876 70588
SGTC_946 3434-1334 87.4 µM -0.840170110485109 0.199813191216858 no 2711 0.200406507246096 3876 4047976
SGTC_667 1498-1044 59 µM -0.842364299479307 0.199201281361942 no 2712 0.199792034896388 3906 6739982
SGTC_466 geldanamycin 89.2 µM -0.842962969406895 0.199034522007542 no 2713 0.199624577181794 3789 5288382 HSP90 inhibitor.
SGTC_3009 9080819 71.4286 µM -0.843636487685578 0.198847014246567 no 2714 0.199436284159138 3909 17027216
SGTC_446 go6976 132 µM -0.843982104382388 0.198750835773351 no 2715 0.199339702896909 3894 3501 A protein kinase C inhibitor.
SGTC_2684 capsaicin 100 µM -0.843989576419943 0.198748756758938 no 2716 0.199337615175692 3916 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1398 3558-0053 112 µM -0.845101754612764 0.19843945133379 no 2717 0.199027014381161 3796 4532369
SGTC_1044 1222-0021 1.78 µM -0.850034848524959 0.197071024122665 no 2718 0.197652855902926 3893 4306703
SGTC_2357 9067248 200 µM -0.850146316146743 0.197040169425361 no 2719 0.197621871974608 3914 9150235
SGTC_1351 1496-0003 46.5 µM -0.851894350947903 0.196556688715535 no 2720 0.197136366243224 3947 3891978
SGTC_2712 st079126 47.7 µM -0.85193046235336 0.196546708415742 no 2721 0.197126344141279 3899 3152970
SGTC_1282 0886-0010 32.4 µM -0.852027760330611 0.196519819188251 no 2722 0.197099342289076 3972 2836211 YNL267W PIK1
SGTC_1040 k898-0338 155 µM -0.853272007930876 0.196176155999931 no 2723 0.196754239667788 3870 20969351
SGTC_1838 st055369 84.5 µM -0.853315845950762 0.196164054518226 no 2724 0.196742087498711 3902 676036
SGTC_1707 st032323 6.317 µM -0.85387815119764 0.19600887034882 no 2725 0.196586253334546 3792 3132057 YMR211W DML1
SGTC_1209 2323-2347 50.3 µM -0.855032150759964 0.195690624594687 no 2726 0.196266674586214 3875 5412760
SGTC_2474 5321570 43.32 µM -0.856910134981756 0.19517339207557 no 2727 0.19574727557946 3931 2841384
SGTC_2967 9089538 49.85 µM -0.857352731085923 0.195051613791448 no 2728 0.195624987209562 3960 728216
SGTC_104 0074-0074 590.992 µM -0.85816971532813 0.19482694569164 no 2729 0.195399378052477 3718 3943124
SGTC_683 panaxydol 45 µM -0.858819451648678 0.194648382654615 no 2730 0.195220067074228 3899 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1203 3992-3522 103 µM -0.858988239826032 0.194602011937036 no 2731 0.195173502124856 4025 5322312
SGTC_444 curcumin 90.4 µM -0.85923785705194 0.19453344759725 no 2732 0.195104650591266 3879 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3346 9158254 43.5805 µM -0.861762919635119 0.193840695558196 no 2733 0.194408996831124 3928 17639500
SGTC_1465 k213-0056 144 µM -0.861951819592352 0.193788931295098 no 2734 0.19435701574356 3798 24048857 YMR208W ERG12
SGTC_1794 st048918 76.9 µM -0.864930901850871 0.192973688062264 no 2735 0.193538357717447 3815 672303
SGTC_2695 st077686 51.995 µM -0.865339479496122 0.192862041959221 no 2736 0.193426243966844 3970 2876092
SGTC_75 0159-0059 199.013 µM -0.866133068791624 0.192645302067554 no 2737 0.193208596227914 3957 5377270
SGTC_453 enantio-paf c16 10 µM -0.868719393236479 0.191939975847586 no 2738 0.192500315673727 3818 13871343 A lipid and platelet activating factor
SGTC_2690 usnic acid 100 µM -0.869222933085752 0.191802837662844 no 2739 0.192362603077617 3919 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3323 9138564 53.9225 µM -0.869466736811759 0.191736459711231 no 2740 0.192295947098943 3951 43912313 YNL103W MET4
SGTC_1382 3002-2117 298 µM -0.870330186545672 0.191501490215592 no 2741 0.192059993427977 3986 1497314
SGTC_2513 baicalein 25.65 µM -0.871178081603487 0.191270925355032 no 2742 0.191828462849304 3938 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1721 st082152 9.2685 µM -0.872313138321057 0.19096254021538 no 2743 0.191518786056492 3877 5296051
SGTC_1073 triclabendazole 3.09 µM -0.873338909051501 0.190684109646491 no 2744 0.19123918931288 4001 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2161 5662504 8.5105 µM -0.873701445375265 0.190585764048289 no 2745 0.191140431809128 3901 2859334
SGTC_2909 7941780 10.49 µM -0.873872101146157 0.190539480863744 no 2746 0.191093954775233 3886 1243215
SGTC_506 n9-isopropylolomoucine 153 µM -0.876315867997356 0.189877469260697 no 2747 0.190429170501956 3927 6610355
SGTC_1594 piperine 70.1 µM -0.87650494212181 0.189826308462289 no 2748 0.190377795433851 3917 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2294 7971431 200 µM -0.876982344147466 0.189697167915421 no 2749 0.190248114028595 3938 5741572
SGTC_1596 piperlongumine 63 µM -0.877933649844107 0.189439994324047 no 2750 0.189989863372551 3973 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1332 1480-0653 17.5 µM -0.877959089916506 0.189433119865829 no 2751 0.189982960123782 3932 5749438
SGTC_2453 5731132 22.18 µM -0.880649573358782 0.188706959899148 no 2752 0.189253759047098 3985 1362040
SGTC_1606 st000094 49.2 µM -0.883099021464672 0.188047349515598 no 2753 0.18859138641346 3929 1242210
SGTC_1330 1469-0054 61.8 µM -0.883285954501547 0.187997068950751 no 2754 0.188540895295329 3960 7102664
SGTC_1432 4049-0298 68.4 µM -0.883914878489416 0.187827964219133 no 2755 0.188371082433393 3970 741646
SGTC_2157 5649910 96.377 µM -0.883922138646832 0.187826012660671 no 2756 0.188369122702797 3927 2858091
SGTC_874 0599-0792 117 µM -0.884509053086302 0.187668289209924 no 2757 0.188210738791538 3938 765305
SGTC_1343 1487-0095 224 µM -0.886977553710749 0.187005817086628 no 2758 0.187545492707759 3949 4560101 YGL055W OLE1
SGTC_1819 st053448 58.6 µM -0.890465324636737 0.186072272810067 no 2759 0.186608039757658 3872 2857616
SGTC_1043 0916-0009 19.3 µM -0.891381358652807 0.185827565002525 no 2760 0.186362307451108 3985 3101130
SGTC_247 mechlorethamine 29.705 µM -0.892459620840617 0.18553977571382 no 2761 0.186073313338686 3855 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1113 artemisinin 1.17947 µM -0.892995136534776 0.185396948878632 no 2762 0.185929888578994 3989 2240 An anti-malaria and mitochondrial poison.
SGTC_607 4491-0986 66.8 µM -0.893762018350136 0.185192533519101 no 2763 0.185724617483381 3975 698981 YDR232W HEM1
SGTC_155 k072-0202 43.6 µM -0.893805553522414 0.18518093324825 no 2764 0.185712968651488 3862 5857737
SGTC_147 4466-0538 29.23 µM -0.893876396994409 0.185162057442305 no 2765 0.18569401382783 4025 6742687 YHR072W ERG7
SGTC_3156 9099931 49.47 µM -0.895389716817651 0.184759128170967 no 2766 0.185289397868184 3978 18111053
SGTC_2691 st077356 60.2 µM -0.896377778507967 0.184496345952506 no 2767 0.185025515679255 4036 2839272
SGTC_731 3966-0296 387 µM -0.897931542634928 0.184083581529756 no 2768 0.184611023569164 3965 660956
SGTC_1531 st059297 52.4 µM -0.898245807063045 0.184000165721608 no 2769 0.184527258625103 3977 7566702
SGTC_1651 st011928 86.1 µM -0.899027681648675 0.183792733393533 no 2770 0.184318958111492 3984 720198
SGTC_336 4111-0029 111 µM -0.899545282063365 0.183655493508588 no 2771 0.184181143839879 3969 3131175
SGTC_1346 1488-2224 62.4 µM -0.899741332417018 0.18360352814133 no 2772 0.184128960986636 3950 3722427
SGTC_2876 9059903 25.97 µM -0.899744963458181 0.183602565779165 no 2773 0.184127994596801 3907 6916095
SGTC_3260 9137109 49.47 µM -0.900094692134733 0.183509889288332 no 2774 0.184034930240079 3895 17478346
SGTC_3102 9121669 49.47 µM -0.900912022228866 0.18329341429413 no 2775 0.183817549286975 3986 41905072
SGTC_754 3474-0146 171 µM -0.902025174863687 0.1829988450841 no 2776 0.18352174734361 3939 24762078
SGTC_1698 5-fluorocytosine 1.055 µM -0.902089888003813 0.182981729390061 no 2777 0.183504560024587 4002 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2060 5238662 140 µM -0.902532060027211 0.182864807986561 no 2778 0.183387149339463 3966 790130
SGTC_515 4092-1064 102 µM -0.904146472036142 0.182438312898626 no 2779 0.182958869582317 3998 717353
SGTC_3342 9147791 14.508 µM -0.904561660228179 0.182328729087662 no 2780 0.18284882724029 3885 1838168
SGTC_3067 9117431 49.47 µM -0.905714065991961 0.18202478134663 no 2781 0.182543607741504 4026 17150885
SGTC_2671 danthron 100 µM -0.909250282219809 0.18109408124651 no 2782 0.181609013939081 3971 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1025 k007-0731 70 µM -0.911670629310229 0.180458789515328 no 2783 0.180971064813979 3951 6256118
SGTC_1138 3761-0006 1.03 µM -0.911986952693979 0.18037586450183 no 2784 0.180887792956172 3948 12061087
SGTC_1641 st009299 47.1 µM -0.912065267199158 0.180355337839639 no 2785 0.180867180439611 3898 4046054
SGTC_1653 st012112 65 µM -0.912895873689836 0.180137721529557 no 2786 0.180648653956388 3966 720429
SGTC_1402 3909-7673 35.9 µM -0.914811166568941 0.179636549338444 no 2787 0.180145385799631 3983 5328014
SGTC_1851 st056236 18.9 µM -0.91519414708824 0.179536440543598 no 2788 0.180044858366247 3949 5393171
SGTC_2432 5630864 12.22 µM -0.915307393318466 0.179506845381525 no 2789 0.180015139443955 4040 5714970
SGTC_3137 9097352 49.47 µM -0.915665026303434 0.179413403631051 no 2790 0.179921306947074 4002 44120435
SGTC_2714 st079313 56.9 µM -0.918047937317514 0.178791581539061 no 2791 0.17929688479874 3965 2939799
SGTC_1855 st056195 39.6 µM -0.91931486963519 0.178461527857798 no 2792 0.178965451209529 3954 4028379
SGTC_788 1182-0090 188 µM -0.919546966769291 0.17840110491458 no 2793 0.178904775658981 4049 5715185
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.920304911443047 0.17820387538222 no 2794 0.17870672160574 4061 688664
SGTC_2456 5770359 74.46 µM -0.920400732713439 0.178178950918076 no 2795 0.178681692947506 4023 3118787
SGTC_642 0335-0876 158 µM -0.92089219423495 0.178051149382086 no 2796 0.178553357161323 4026 6812350
SGTC_1907 st060210 83.7 µM -0.921470878114286 0.177900740320628 no 2797 0.178402319366113 4047 688793
SGTC_784 4579-0127 173 µM -0.921948718170804 0.177776602579932 no 2798 0.17827766272881 4071 1948547
SGTC_1371 2421-0008 32.7 µM -0.922158075902253 0.177722230898322 no 2799 0.178223063778606 3970 2827552
SGTC_2993 9054257 71.4286 µM -0.923397390272 0.177400587112438 no 2800 0.177900075619638 3943 6470217 YGL055W OLE1
SGTC_1413 3910-0535 34.4 µM -0.924039844609598 0.177233993321627 no 2801 0.1777327855639 3995 2876951
SGTC_899 1083-0020 478 µM -0.925223140105526 0.176927413563455 no 2802 0.17742492456525 4068 767123
SGTC_2986 9022445 71.43 µM -0.925793341969439 0.176779799824522 no 2803 0.177276693966909 4017 6459286
SGTC_1451 4152-0210 104 µM -0.926595106287651 0.176572370986291 no 2804 0.177068398353364 4000 659563
SGTC_1973 st070275 50.2 µM -0.926596985584854 0.17657188496391 no 2805 0.177067910300119 3932 17118334
SGTC_456 gingerol 170 µM -0.928353780115752 0.176117914228166 no 2806 0.176612042755894 4010 442793 A herb.
SGTC_97 0535-0701 19.132 µM -0.929549645797466 0.175809315335591 no 2807 0.176302154602129 3915 2832013 YGL099W LSG1
SGTC_2309 7664088 163.95 µM -0.930679484803627 0.175518069814175 no 2808 0.176009692428769 4022 704922
SGTC_2220 6782180 200 µM -0.931457553579249 0.175317680169128 no 2809 0.175808465737354 3928 833803
SGTC_2282 7944268 200 µM -0.933685785715916 0.174744607587521 no 2810 0.175232999668763 4046 2970414
SGTC_1024 4507-0395 26 µM -0.934420105910612 0.174556010713351 no 2811 0.175043615199601 4097 4201836
SGTC_2009 4012297 12.05 µM -0.934693997594714 0.17448569969401 no 2812 0.174973010568432 4026 45595307
SGTC_270 tamoxifen 5.46 µM -0.936388977479059 0.174050979841175 no 2813 0.174536475519903 4031 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_488 nitrendipine 139 µM -0.93642111338551 0.174042744443151 no 2814 0.174528205737077 4061 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_612 0302-0167 22.4 µM -0.938448735402435 0.17352363117023 no 2815 0.174006925232982 4033 235821
SGTC_33 0986-0033 35.816 µM -0.938781977660883 0.173438408621877 no 2816 0.17392134692832 3927 2848082
SGTC_1169 aniline yellow 25.8 µM -0.939036555156113 0.173373321558561 no 2817 0.173855988170134 3948 6051 A DNA damaging agent.
SGTC_3347 9188721 44.724 µM -0.941274970982874 0.172801702086337 no 2818 0.173281982836918 4054 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2346 9031566 143.75 µM -0.94265812797681 0.172449089374288 no 2819 0.172927898611476 3989 4771086
SGTC_79 0052-0007 94.094 µM -0.945436257962114 0.171742239347819 no 2820 0.172218099354273 4004 2801472
SGTC_252 miconazole 1.30953 nM -0.945521109373022 0.17172067944999 no 2821 0.172196449513152 3939 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2546 rhodinyl acetate 100 µM -0.947087936785566 0.171322874960153 no 2822 0.171796985601066 3956 6708682
SGTC_323 4013-0906 34.3 µM -0.947527523776651 0.171211373380218 no 2823 0.171685018943406 4023 2910086
SGTC_705 1124-0212 310 µM -0.949527001422709 0.170704790039831 no 2824 0.171176322879319 3982 9554485
SGTC_1084 voriconazole 435 nM -0.949746353471977 0.170649273936547 no 2825 0.171120575270011 4034 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_369 0957-0393 4.5 µM -0.952141000390059 0.170043961507573 no 2826 0.170512738983588 4080 6997992
SGTC_3282 9108498 15.4605 µM -0.952721573081417 0.169897413422662 no 2827 0.170365579958879 4030 16459645
SGTC_2541 muurolladie-3-one 83.07 µM -0.955390185312703 0.169224844568043 no 2828 0.169690207734406 4064 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1910 st062352 60.4 µM -0.955679660074544 0.169151991309951 no 2829 0.169617050860942 3969 2245730
SGTC_1210 3013-0140 750 nM -0.956042219641212 0.169060772922326 no 2830 0.169525452334856 4071 905973
SGTC_3248 9135562 49.47 µM -0.956467296740395 0.168953865639861 no 2831 0.169418099552001 4024 17650701
SGTC_2397 5161689 200 µM -0.956638136505867 0.168910911517781 no 2832 0.169374966438792 4090 2259942
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.956938155657164 0.168835494893395 no 2833 0.169299235559154 4088 688788
SGTC_2378 9074213 121.43 µM -0.957582287493973 0.168673650834788 no 2834 0.169136717143876 4015 657714
SGTC_2820 7989630 71.43 µM -0.958141965955224 0.168533107453059 no 2835 0.16899558819813 4021 2984098
SGTC_687 k029-0044 34.9 µM -0.961906387464639 0.167589763532634 no 2836 0.16804831485801 4131 5829338
SGTC_2817 7995342 71.43 µM -0.963878460677211 0.167096932782446 no 2837 0.167553431939985 4048 18879975
SGTC_3274 9138298 49.47 µM -0.963903965483196 0.16709056513346 no 2838 0.167547037778949 4007 17015756
SGTC_1176 0848-0131 83.3 µM -0.964235758813046 0.167007742318322 no 2839 0.167463870133818 4079 6769040
SGTC_1417 3966-0327 90.4 µM -0.964352534849948 0.166978598785231 no 2840 0.167434605265831 4142 651118
SGTC_287 k060-0039 29.6 µM -0.966278452206281 0.166498425077746 no 2841 0.166952432667782 4106 5861974
SGTC_1710 st031758 61.5 µM -0.966336167606846 0.166484049124615 no 2842 0.166937996876859 4080 5394341
SGTC_326 k292-0812 17.5 µM -0.966350029245334 0.166480596538729 no 2843 0.166934529920155 4026 3579357
SGTC_3336 9143619 71.43 µM -0.966952318661835 0.166330626015043 no 2844 0.166783935192196 4088 45595730
SGTC_780 0109-0199 192 µM -0.968299023623716 0.165995611181014 no 2845 0.166447526131787 4165 610414
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.970626898709126 0.165417543314803 no 2846 0.165867053074788 4132 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.973202740054482 0.16477941913124 no 2847 0.165226274641539 3863 88881 An O-methylated flavonoid and antioxidant.
SGTC_2064 5220758 200 µM -0.973936051431891 0.164598044760701 no 2848 0.165044146012247 4128 788518
SGTC_277 nystatin 15.5 µM -0.975339565326815 0.164251266015763 no 2849 0.164695925362491 4049 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_608 k048-0125 159 µM -0.975400523017641 0.16423621539621 no 2850 0.164680812168512 4112 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1139 k015-0024 46.9 µM -0.975500758943666 0.164211468818066 no 2851 0.164655962705135 4089 2766652
SGTC_505 gw-5074 63.9 µM -0.97790829627373 0.163617814620951 no 2852 0.164059840768482 4108 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2890 9046729 58.44 µM -0.978592605840732 0.163449331175178 no 2853 0.163890657104823 3998 903329
SGTC_1233 0325-0408 14.2 µM -0.979230179611487 0.163292455960882 no 2854 0.163733129974752 4108 12874
SGTC_846 0335-0850 148 µM -0.980537936005276 0.162970988323181 no 2855 0.163410326612585 4050 6819598
SGTC_137 0438-0332 85.389 µM -0.981267034616305 0.162791942866839 no 2856 0.163230537311655 4041 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2797 7859098 81.82 µM -0.981421645786411 0.162753991297635 no 2857 0.163192428082229 4056 972681
SGTC_3176 9106582 49.47 µM -0.982886076569826 0.162394810784164 no 2858 0.162831755611817 4006 17018027
SGTC_635 k038-0028 24.7 µM -0.983420143248412 0.162263948887107 no 2859 0.162700350219179 4077 4035102
SGTC_1784 st039334 36.3 µM -0.984165049868929 0.162081539749597 no 2860 0.162517183568395 4149 3496984
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.98765003722913 0.161229927489792 no 2861 0.161662035779343 4110 688664
SGTC_888 0916-0002 6.97 µM -0.991860159722268 0.16020501732616 no 2862 0.160632873019382 4129 2802138 YIL048W NEO1
SGTC_1989 st071868 50.2 µM -0.992162108321671 0.160131675140599 no 2863 0.160559226622175 4057 16414057
SGTC_2094 5332512 191.667 µM -0.992327239258953 0.160091574740037 no 2864 0.16051895989744 4112 755774
SGTC_733 4069-0007 56.1 µM -0.993934387669653 0.159701637729946 no 2865 0.160127405765815 4074 5717425 YNL287W SEC21
SGTC_1117 retinoic acid 1.10837 µM -0.998665311993946 0.158557399829539 no 2866 0.15897842487759 4135 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2591 skatole 100 µM -1.0008455456355 0.158031895175757 no 2867 0.158450743139583 4129 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1320 1313-0481 95.3 µM -1.00314158454595 0.157479715317221 no 2868 0.157896276512272 4083 6813365 YLR208W SEC13
SGTC_319 1348-1596 45.5 µM -1.00415142508294 0.157237258324043 no 2869 0.157652815692051 4187 5380505
SGTC_3266 9136860 49.47 µM -1.00463707907509 0.15712074299906 no 2870 0.157535818026727 3940 4871271 YPR165W RHO1
SGTC_2087 5276107 200 µM -1.00513141610751 0.157002202817002 no 2871 0.157416787161897 4057 144405
SGTC_1923 st058458 19.1 µM -1.00552322329967 0.156908290712388 no 2872 0.157322486348141 4129 3534982
SGTC_547 1120-0019 610 nM -1.00653998457785 0.156664756054572 no 2873 0.157077943801087 4051 3676939
SGTC_1785 bathophenanthroline 24 µM -1.00697371963756 0.156560943581339 no 2874 0.156973701743301 4017 72812 An iron chelator.
SGTC_3060 1327-0027 12.5 µM -1.00712446765822 0.156524873350558 no 2875 0.156937482258294 3995 16000455 YPR107C YTH1
SGTC_2221 6807166 181.081 µM -1.00715398299401 0.156517811709531 no 2876 0.1569303913975 4048 674925
SGTC_3062 9077494 49.47 µM -1.00804503792825 0.15630472264885 no 2877 0.156716420682318 4082 16459633
SGTC_2515 chrysin 20.77 µM -1.00856503510317 0.156180457589579 no 2878 0.156591641538844 4129 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2607 solasodine 47.35 µM -1.01067399008991 0.155677142703257 no 2879 0.156086244908762 4085 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2773 thioridazine 9.09 µM -1.01073929948843 0.155661573314993 no 2880 0.156070611136542 4126 5452 An antipsychotic.
SGTC_3173 9105693 49.47 µM -1.01144958899237 0.155492310668274 no 2881 0.155900648586548 4114 17096658
SGTC_2415 st077333 57.7 µM -1.01174046342689 0.15542303007921 no 2882 0.155831081546271 4151 2766255
SGTC_282 k297-0036 65.7 µM -1.01424589211107 0.154827129467483 no 2883 0.155232717695627 4101 5061378
SGTC_2493 resveratrol 26.09 µM -1.01507013198346 0.154631419518203 no 2884 0.155036198989816 4009 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2828 7998861 71.43 µM -1.01553616140864 0.154520836496383 no 2885 0.154925159044585 4074 2988188
SGTC_3171 9103192 49.47 µM -1.01669373966517 0.154246383715729 no 2886 0.154649572403964 4159 13018434
SGTC_670 4204-0025 119 µM -1.01961826736521 0.153554437925683 no 2887 0.153954769000618 4113 719039
SGTC_3161 9100388 49.47 µM -1.02202229635238 0.15298718430882 no 2888 0.153385173872743 4173 25236368
SGTC_601 0986-0029 62.9 µM -1.0231849634486 0.152713340938552 no 2889 0.153110200506419 4059 24747981
SGTC_710 3448-4187 58 µM -1.02354154491788 0.15262942037532 no 2890 0.153025933700081 4085 3946412
SGTC_450 aminopyrene 156 nM -1.02473114825593 0.152349671511198 no 2891 0.152745030804397 4025 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3181 9108277 49.47 µM -1.02582119827305 0.152093632748869 no 2892 0.152487936048989 4057 17097298
SGTC_959 1222-0044 107 µM -1.02718094149386 0.151774647297022 no 2893 0.152167635298281 4127 6083612
SGTC_2002 4023503 131 µM -1.02835048335604 0.151500637525698 no 2894 0.151892495955461 4119 4736863 YCR052W RSC6
SGTC_2586 curcumin 80 µM -1.02844340384654 0.151478881470556 no 2895 0.15187065022464 4068 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_425 3825-7017 13.1 µM -1.02974834165786 0.151173567659561 no 2896 0.151564078120492 4178 3397440
SGTC_65 0798-0905 34.986 µM -1.0299998324779 0.151114773917574 no 2897 0.151505042108089 4237 3602145
SGTC_2108 5365811 200 µM -1.03007910324166 0.151096245083598 no 2898 0.151486436925125 4131 780283
SGTC_1700 st030840 7.9285 µM -1.03211091067924 0.150621844143224 no 2899 0.151010081598526 4177 5499307
SGTC_1370 2001-0092 44.6 µM -1.03611891393556 0.149688938200951 no 2900 0.150073334685241 4189 790957
SGTC_2385 9074692 200 µM -1.03715148616806 0.149449221739063 no 2901 0.149832631763714 4135 17046906
SGTC_2891 9063876 19.48 µM -1.0379966920945 0.149253194055238 no 2902 0.149635797559494 4124 6472478
SGTC_1959 st077091 55.8 µM -1.03811289818967 0.149226255934479 no 2903 0.149608748617673 4116 821356 YKL052C ASK1
SGTC_1877 wortmannin 25 µM -1.04075468771847 0.148614729795697 no 2904 0.148994707432005 4132 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1239 0337-0584 35.4 µM -1.04346183203843 0.147989815652109 no 2905 0.148367224618238 4211 914301 YML130C ERO1
SGTC_1487 3970-0795 2.82 µM -1.04363313948087 0.1479503304933 no 2906 0.148327577207595 4172 3765103
SGTC_964 1287-0107 19.4 µM -1.04404195916589 0.147856128934368 no 2907 0.148232988580899 4154 51516812 YPR165W RHO1
SGTC_685 1278-0033 54.9 µM -1.04419122188883 0.147821745342693 no 2908 0.148198463717799 4206 3590572
SGTC_3217 9129673 49.47 µM -1.05032090764597 0.146414358094269 no 2909 0.146785297867819 4185 17248312
SGTC_2811 7967822 32.47 µM -1.05063334513143 0.146342863620801 no 2910 0.146713510051441 4198 2232244
SGTC_2470 5664817 21.68 µM -1.05205632278092 0.146017542892454 no 2911 0.146386854783905 4168 2859561
SGTC_449 xestospongin c 11.1929 µM -1.05352929585446 0.145681304386504 no 2912 0.146049237396896 4162 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3083 9117465 49.47 µM -1.05772082270561 0.144727346179209 no 2913 0.145091369601552 4144 16420915
SGTC_2656 pseudo-anisatin 100 µM -1.0577410626087 0.144722749968491 no 2914 0.145086754563332 4178 6708809 A neurotoxin.
SGTC_2174 5790901 200 µM -1.05842762234755 0.144566899679348 no 2915 0.144930265915096 4155 786020
SGTC_431 k089-0097 107 µM -1.05926644867477 0.144376638122438 no 2916 0.144739225188543 3961 5499420
SGTC_2816 7982706 58.44 µM -1.05935128581155 0.144357404868576 no 2917 0.144719913178019 4183 2981853
SGTC_414 piperonyl butoxide 100 µM -1.06292388144443 0.143549036376662 no 2918 0.143908235975941 4149 5794 A potent inhibitor of cytochrome P450.
SGTC_2396 5342950 42.78 µM -1.06563125512649 0.142938479922868 no 2919 0.14329518232189 4142 1886677
SGTC_567 1080-0542 68.4 µM -1.06688196427401 0.142657018298468 no 2920 0.143012570052814 4022 5950415
SGTC_2451 5856223 45.7 µM -1.06757145770796 0.142502013914883 no 2921 0.142856932143142 4131 2179896
SGTC_256 clotrimazole 625 nM -1.06790697314161 0.142426628215514 no 2922 0.142781238369346 4095 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_779 1360-0071 233 µM -1.06826327953936 0.142346600613235 no 2923 0.142700883750266 4220 7566
SGTC_1654 st012436 41.8 µM -1.07087821803181 0.1417602076979 no 2924 0.142112095524827 4149 4323132
SGTC_794 k038-0031 316 µM -1.07563908034843 0.140696803192893 no 2925 0.141044351155852 4150 6624242
SGTC_938 3126-1755 342 µM -1.0756639306605 0.140691266771515 no 2926 0.141038792153292 4178 1777771
SGTC_2738 aclarubicin 5.55 µM -1.07735665015179 0.140314492416578 no 2927 0.140660481397129 4141 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1263 0774-1208 64.8 µM -1.07862147316089 0.140033409194973 no 2928 0.140378252411647 4228 906585
SGTC_724 3910-0327 137 µM -1.07910808676544 0.139925370419044 no 2929 0.140269773341769 4231 2885483
SGTC_2531 methyl deoxycholate 70.07 µM -1.07963090563406 0.139809356432132 no 2930 0.140153286620429 4111 16667744 Haematoxylin.
SGTC_2226 7298446 200 µM -1.08181207981384 0.139326057417497 no 2931 0.139668018941974 4159 3283010
SGTC_410 α-linolenic acid 100 µM -1.08257206979926 0.139157928119141 no 2932 0.139499205048911 4227 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_732 3970-1727 52.7 µM -1.08262615253899 0.139145968893478 no 2933 0.139487197132418 4246 1275699
SGTC_1026 k007-1105 30.6 µM -1.08263604740568 0.139143780933875 no 2934 0.139485000264824 4161 7066794
SGTC_829 1635-0120 117 µM -1.0826908534165 0.1391316626158 no 2935 0.139472832609018 4182 285054
SGTC_1331 1472-0049 76.2 µM -1.08486458420053 0.138651601813686 no 2936 0.138990817888106 4116 24051409
SGTC_3228 9131799 49.47 µM -1.08519346082266 0.138579068961389 no 2937 0.138917989913391 4171 17015818
SGTC_3127 9126946 49.47 µM -1.0857447063063 0.138457551246615 no 2938 0.138795977823517 4175 27243249
SGTC_345 1362-0200 395 µM -1.08587827756004 0.138428117451064 no 2939 0.138766424292188 4167 1419823
SGTC_3190 9110366 49.47 µM -1.08603535927001 0.138393508341999 no 2940 0.138731674399743 4191 17123768
SGTC_464 bw-b 70c 158 µM -1.08768303032448 0.138030839720424 no 2941 0.138367530863474 4205 5353454
SGTC_1922 5578187 25 µM -1.0879266068297 0.137977281177393 no 2942 0.138313754561383 4202 1350412
SGTC_2992 9074591 71.4286 µM -1.09058282424047 0.137394141949157 no 2943 0.137728245319407 4145 17741321
SGTC_2469 5655019 90.81 µM -1.09075970956291 0.137355368847981 no 2944 0.137689314695512 4238 2788239
SGTC_993 3909-8757 62.7 µM -1.09095150558431 0.137313335779238 no 2945 0.137647110868368 4121 4288324 YLR208W SEC13
SGTC_1744 st037937 38.9 µM -1.0909802436424 0.137307038445169 no 2946 0.137640787952285 4265 1016152
SGTC_278 4092-0821 23.9 µM -1.09398054885996 0.136650670401662 no 2947 0.136981754607071 4180 877900
SGTC_1034 k072-0165 12.7 µM -1.0944774102099 0.136542180897767 no 2948 0.136872824772848 4217 5835461
SGTC_2492 derrusnin 100 µM -1.09452376645945 0.136532062031844 no 2949 0.136862664840184 4180 1715307 Part of coumarin class of compounds.
SGTC_362 0310-0100 9.03 µM -1.09555092734696 0.136307979974061 no 2950 0.136637673495048 4264 790235
SGTC_2612 dictamnine 15.46 µM -1.09733271841896 0.13591986738819 no 2951 0.13624798662642 4141 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1676 st018489 23.4 µM -1.09798116775907 0.135778809086825 no 2952 0.136106356350676 4216 3696235
SGTC_1722 st034304 3.6505 µM -1.09897342358023 0.135563156116594 no 2953 0.135889829134578 4168 4036148 YLR033W RSC58
SGTC_2815 7968870 71.43 µM -1.10028494994726 0.135278474401592 no 2954 0.135603993708706 4153 2977326 YHR190W ERG9
SGTC_2262 9014885 67.46 µM -1.10074976479884 0.135177679480564 no 2955 0.135502790405226 4166 6457424
SGTC_934 2950-0684 338 µM -1.10189925352063 0.134928634464809 no 2956 0.13525273658539 4233 1121253
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.10431148496264 0.134407030902001 no 2957 0.134729021241854 4216 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2496 diffractaic acid 79.83 µM -1.10480536627908 0.134300408538983 no 2958 0.134621967384303 4223 94870 An apoptosis inducer which activates caspases.
SGTC_1010 4112-3296 15.2 µM -1.10593418078909 0.134056930747154 no 2959 0.13437750448281 4268 704384
SGTC_697 0508-1955 564 µM -1.10739503931826 0.133742283718849 no 2960 0.134061584872723 4195 6243113
SGTC_569 4130-2812 160 µM -1.10894946936362 0.133408040710161 no 2961 0.133725990621627 4032 743552
SGTC_1956 st077085 54 µM -1.10937246559232 0.133317185028739 no 2962 0.133634767744983 4250 24208685
SGTC_848 0368-0089 85.6 µM -1.10983718623887 0.133217416414415 no 2963 0.133534595966312 4212 762535
SGTC_124 0136-0217 7.121 µM -1.11030794659765 0.133116403558591 no 2964 0.133433174974486 4253 3976905
SGTC_1281 0884-0031 11.8 µM -1.11454573518876 0.132209458134324 no 2965 0.132522567656052 4223 1548255
SGTC_1140 3229-1848 2.98 µM -1.11865503349999 0.131334088215239 no 2966 0.131643667769052 4237 2849525
SGTC_2792 7535235 81.82 µM -1.12157959897288 0.130713535081634 no 2967 0.131020614917689 4212 1281891
SGTC_1875 nocodazole 6 µM -1.12354020950482 0.1302986567689 no 2968 0.130604066652056 4238 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_115 0527-0192 112.043 µM -1.12372499116711 0.130259602759735 no 2969 0.130564855496721 4195 4233931
SGTC_3194 9111903 49.47 µM -1.12446689745653 0.13010288077999 no 2970 0.130407502987925 4251 17087251
SGTC_716 1683-5115 658 µM -1.12447657101409 0.130100838177805 no 2971 0.130405452168843 4178 723597
SGTC_648 0375-0473 33.3 µM -1.12494418804745 0.130002125832557 no 2972 0.130306342757356 4187 1713139
SGTC_2353 9059630 146.67 µM -1.12519305200614 0.129949612650446 no 2973 0.130253618366971 4247 4779114
SGTC_1498 4478-3555 97.6 µM -1.12678478119993 0.12961408665168 no 2974 0.129916743272383 4197 3437919
SGTC_185 k048-0037 25.491 µM -1.12696776914771 0.129575552494935 no 2975 0.129878054219493 4276 6827589
SGTC_2092 5303694 80.6725 µM -1.12810265849468 0.129336741297708 no 2976 0.129638283271165 4215 1963699
SGTC_2079 5212404 121 µM -1.13106905975971 0.128713972046933 no 2977 0.129013012829237 4197 758462
SGTC_1114 scopoletin 1.73284 µM -1.13366018904113 0.12817169274679 no 2978 0.12846855755386 4255 5280460 A coumarin with genotoxic properties.
SGTC_1267 0828-0272 9.49 µM -1.13417428835864 0.128064289416747 no 2979 0.128360723469565 4306 745334
SGTC_3262 9137218 49.47 µM -1.13577931120406 0.127729377560991 no 2980 0.128024468873614 4139 17650664
SGTC_1921 5740136 50 µM -1.1359892417843 0.127685617489253 no 2981 0.127980533409687 4186 1774243
SGTC_2867 9039098 71.43 µM -1.14036417159457 0.126776033500238 no 2982 0.12706730652904 4194 6463460
SGTC_20 0481-0013 4.944 µM -1.14255959715909 0.126321290485413 no 2983 0.126610744259733 4270 182045
SGTC_1 0258-0098 57.368 µM -1.1514199395653 0.124497585785404 no 2984 0.124779757297871 4193 6790032 YDR047W HEM12
SGTC_809 3998-0021 90 µM -1.15177854299468 0.124424164832272 no 2985 0.12470604363355 4198 715485
SGTC_1276 0871-0068 94.2 µM -1.15217605130611 0.124342813829242 no 2986 0.124624368347032 4245 3414906
SGTC_781 4335-2806 94.4 µM -1.1545118905602 0.123865530396085 no 2987 0.124145183265954 4303 845254
SGTC_562 3772-2733 112 µM -1.15871385376384 0.123010172169692 no 2988 0.123286420961515 4229 2876874 YIL048W NEO1
SGTC_654 1124-0271 80.9 µM -1.16003669956782 0.12274175062168 no 2989 0.123016932228397 4219 5403748
SGTC_1622 st003707 19.4 µM -1.16204520980728 0.122334985261368 no 2990 0.122608550629824 4272 10140899
SGTC_895 0964-0006 13.7 µM -1.16210054642591 0.122323791846898 no 2991 0.122597312756163 4232 6738897
SGTC_605 1315-0399 119 µM -1.16362016640752 0.122016686124445 no 2992 0.122288987587985 4323 24020461
SGTC_2406 ethylparaben 405.7 µM -1.16409701265474 0.121920430182801 no 2993 0.122192349575481 4262 8434 A possible steroid mimic.
SGTC_527 4476-4215 268 µM -1.1643329237638 0.121872829012403 no 2994 0.122144559485327 4243 4418754
SGTC_3213 9129884 49.47 µM -1.17184057601736 0.120364780425959 no 2995 0.120630534290836 4250 17190742
SGTC_175 3793-3120 23.7 µM -1.17487481404455 0.119759043629254 no 2996 0.120022401611244 4257 5322297
SGTC_2908 7930301 100 µM -1.1790586474679 0.118927338894873 no 2997 0.119187411737686 4234 2223178
SGTC_2544 sphondin 68.51 µM -1.1807249497022 0.118597232923411 no 2998 0.118856003353689 4248 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2127 5253358 187.912 µM -1.18099585214339 0.118543626527542 no 2999 0.118802185536587 4169 20612
SGTC_1378 2093-0007 380 nM -1.1824877673706 0.118248711945697 no 3000 0.118506108223811 4322 3618014
SGTC_2229 7354935 190 µM -1.18747419230468 0.117266785360801 no 3001 0.11752031520732 4217 318112
SGTC_1252 0493-0875 34.8 µM -1.18875847381139 0.117014822677935 no 3002 0.117267361629036 4253 3960963
SGTC_985 1493-0307 8.71 µM -1.19187220069203 0.116405535064906 no 3003 0.116655679973939 4297 3278274
SGTC_661 1304-0007 33.6 µM -1.19322105239278 0.116142294408124 no 3004 0.116391405909381 4279 3117130
SGTC_1426 4048-4480 71.7 µM -1.19632349080446 0.115538429555701 no 3005 0.115785172598496 4281 14224343
SGTC_128 0906-2981 13.371 µM -1.19714149325235 0.115379584201079 no 3006 0.115625704725417 4277 6740226
SGTC_511 blebbistatin 171 µM -1.19967810916455 0.114887993705441 no 3007 0.115132189005857 4335 3476986 A myosin inhibitor.
SGTC_917 harmaline 728.087 nM -1.2053796379798 0.113788492545839 no 3008 0.114028389220919 4230 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_568 1193-0097 7.48 µM -1.20538693316636 0.113787090539276 no 3009 0.114026981739628 4099 3646150
SGTC_2810 7959871 45.46 µM -1.20545126700435 0.113774727240008 no 3010 0.114014570163348 4256 2974535
SGTC_849 0386-0493 241 µM -1.20594253714882 0.113680349397453 no 3011 0.113919823831385 4284 726119
SGTC_3162 9099653 49.47 µM -1.20597668103543 0.113673792094649 no 3012 0.113913240929056 4260 25237511
SGTC_1255 0566-0045 221 µM -1.20610220928402 0.113649686824922 no 3013 0.113889041556218 4305 2788469
SGTC_2379 9035213 200 µM -1.20666364267702 0.113541919008921 no 3014 0.113780853093171 4284 646551
SGTC_1422 4031-0024 15.5 µM -1.21319168035818 0.112294200850418 no 3015 0.112528272112163 4224 782427
SGTC_1817 st052116 64.4 µM -1.21414038153564 0.112113692110598 no 3016 0.112347060996812 4318 4361398
SGTC_1174 0739-0097 51.1 µM -1.21425211762368 0.112092445820638 no 3017 0.112325732054706 4329 728447
SGTC_2912 7964298 10.93 µM -1.21517675509943 0.111916739165016 no 3018 0.112149342020707 4303 2975850
SGTC_2619 obliquin 87.91 µM -1.21544065886323 0.111866626309053 no 3019 0.112099034310632 4256 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.21885141336544 0.111220399447314 no 3020 0.111450296742824 4366 165506
SGTC_598 3937-0236 20.2 µM -1.2190533165687 0.111182229333312 no 3021 0.111411978449128 4363 1379313
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.21990675230075 0.111020989601331 no 3022 0.11125011291659 4260 676296 Flavone; oxidizing agent.
SGTC_2504 purpurogallin 52.29 µM -1.22241584396751 0.11054791673204 no 3023 0.110775205335728 4199 5281571 An antioxidant.
SGTC_1399 3562-5772 25 µM -1.22408813456635 0.110233420777532 no 3024 0.110459490814419 4287 23847490
SGTC_1571 st070080 73.4 µM -1.22903425267314 0.109306996142941 no 3025 0.109529481941194 4320 4315245
SGTC_329 k048-0121 21.3 µM -1.23015657915749 0.109097561449179 no 3026 0.109319238084733 4330 6832902
SGTC_1142 3253-1408 9.78 µM -1.23453797173386 0.108282720760527 no 3027 0.108501253189729 4332 256655
SGTC_2103 5378138 10 µM -1.23594652062605 0.108021695024548 no 3028 0.108239221590079 4386 244142
SGTC_1111 tnp00062 510.699 nM -1.2402348205601 0.107229797274847 no 3029 0.107444276320967 4354 676306
SGTC_589 1227-0070 34.1 µM -1.24481223982482 0.10638913730789 no 3030 0.106600387954153 4376 2841384
SGTC_325 2810-4341 181 µM -1.24662212390678 0.106058061672902 no 3031 0.106268042825663 4325 774970
SGTC_1821 st053465 65.6 µM -1.25046683999195 0.105357233119801 no 3032 0.105564530646599 4345 675086
SGTC_2288 7946289 167.31 µM -1.25097094591534 0.105265591902748 no 3033 0.105472538886434 4367 1246052
SGTC_1832 st054113 55 µM -1.2646571850234 0.102799575062544 no 3034 0.102997122097198 4359 1251267
SGTC_2918 7977171 22.06 µM -1.26684792048492 0.102408773443673 no 3035 0.102604836782595 4337 2236483
SGTC_417 st075190 100 µM -1.26729252169212 0.102329593826162 no 3036 0.102525356758886 4332 222757
SGTC_1630 st005209 31.3 µM -1.26769155660357 0.102258567090841 no 3037 0.102454060607617 4327 3367314
SGTC_2116 5511452 16.8835 µM -1.26888972833344 0.102045512461863 no 3038 0.102240198159648 4353 870744
SGTC_1505 k297-0037 20.6 µM -1.26983614751906 0.10187745203584 no 3039 0.102071500867154 4334 4089396
SGTC_1236 0330-0013 258 µM -1.27106303654436 0.101659887136436 no 3040 0.101853111967013 4358 4617066
SGTC_827 3253-0474 693 µM -1.27154008347935 0.101575383550618 no 3041 0.10176828847553 4367 5402065
SGTC_1311 1190-0148 100 µM -1.27569083835218 0.10084228127327 no 3042 0.101032414234484 4398 1961333
SGTC_1976 st070609 63.5 µM -1.27898827108862 0.100262647528522 no 3043 0.100450593100865 4294 682556
SGTC_889 0919-1524 82.7 µM -1.27922071683918 0.10022187938184 no 3044 0.100409671249571 4367 3905452
SGTC_374 0880-0231 82.3 µM -1.28146816399007 0.0998283285394585 no 3045 0.100014637615928 4227 6833587
SGTC_1489 4065-0444 182 µM -1.2818548912001 0.0997607226640917 no 3046 0.0999467771994955 4363 2877968
SGTC_474 dl-dihydrosphingosine 5 µM -1.28274777946777 0.0996047598095526 no 3047 0.0997902273347572 4353 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_234 nsc-17383 10.7 µM -1.28478705066922 0.0992492239205494 no 3048 0.0994333543405688 4366 408974
SGTC_288 1315-0019 35.1 µM -1.28631399916829 0.0989836168927739 no 3049 0.0991667493753169 4380 6811474
SGTC_29 0299-0004 12.984 µM -1.291027862204 0.0981669388722441 no 3050 0.0983470081406601 4249 16871 A napthoquinone isolated from Swertia calycina.
SGTC_409 arachidonic acid 100 µM -1.29831317329218 0.096914483701588 no 3051 0.0970898707442298 4352 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1516 st013856 110 µM -1.29869477958062 0.0968492046547497 no 3052 0.0970243481783123 4399 5281404 A mutagen and neurotoxin.
SGTC_3004 9076122 71.4286 µM -1.30052974310668 0.0965357595442112 no 3053 0.09670973451135 4363 44782551
SGTC_1879 gemcitabine 100 µM -1.30091938299796 0.0964692980069557 no 3054 0.0966430253541023 4330 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3059 1327-0034 3 µM -1.30865941040753 0.0951560276295215 no 3055 0.0953248733427546 4215 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1077 5-fluorocytosine 377 nM -1.30869715088206 0.0951496565229368 no 3056 0.0953184786067072 4427 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_309 k408-0051 1.48 µM -1.31069308066289 0.0948131638403039 no 3057 0.0949807386590592 4285 3640463
SGTC_1230 0170-0365 3.77 µM -1.31244063417214 0.0945192654634292 no 3058 0.0946857520855427 4408 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1131 3454-3128 32.3 µM -1.31310963149928 0.0944069334285312 no 3059 0.0945730044203435 4395 710982
SGTC_421 streptovitacin 30 mM -1.31364809050971 0.0943165917463287 no 3060 0.0944823285906846 4388 91467 include heat shock
SGTC_3261 9137475 49.47 µM -1.31593664824457 0.0939333329762662 no 3061 0.0940976534350408 4365 17027690
SGTC_55 0767-0285 6.563 µM -1.31628358858557 0.0938753322564951 no 3062 0.0940394385321263 4281 3116166
SGTC_1434 4073-0095 163 µM -1.31797303065096 0.0935932727888877 no 3063 0.093756338111819 4368 24133745
SGTC_3107 9121808 49.47 µM -1.31942236419033 0.0933517995875863 no 3064 0.0935139745732077 4325 662681
SGTC_1718 roemerine 11.9335 µM -1.32092312149464 0.093102244037915 no 3065 0.0932634996946585 4028 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2557 derrustone 83.84 µM -1.32640040191133 0.0921956300721997 no 3066 0.0923535528733813 4368 629853 An antioxidant.
SGTC_2402 5553605 200 µM -1.3289199233561 0.0917807935036692 no 3067 0.0919371949952485 4459 6758546
SGTC_2862 9027634 71.43 µM -1.33172013986106 0.0913213649493833 no 3068 0.0914760843427015 4340 5012562
SGTC_2796 7949634 45.45 µM -1.33257631925311 0.0911812334208984 no 3069 0.0913354403304533 4355 2971588
SGTC_997 3996-0078 137 µM -1.33360660670637 0.0910128169621182 no 3070 0.0911664083044489 4431 735687
SGTC_4 0960-0234 25.671 µM -1.33426036346734 0.0909060700100038 no 3071 0.0910592713926005 4392 6821112
SGTC_2917 7979103 53.79 µM -1.3355837137403 0.0906902746063151 no 3072 0.0908426881458829 4396 2980565
SGTC_2836 9010338 19.48 µM -1.33968407536346 0.0900240531214807 no 3073 0.090174038482191 4363 2994051
SGTC_372 0155-0182 15.9 µM -1.3440750632488 0.0893146507650948 no 3074 0.0894620574774478 4282 771486
SGTC_2081 5214970 32.255 µM -1.34563009857306 0.0890644210543354 no 3075 0.0892109199123798 4339 2063512
SGTC_106 0092-0003 11.579 µM -1.34611456061305 0.0889865701720296 no 3076 0.0891327867648986 4309 1072148
SGTC_3354 9151612 71.43 µM -1.34810083101841 0.0886679149449856 no 3077 0.0888129771006002 4397 27261949
SGTC_2137 5261020 140 µM -1.34819656605021 0.088652577772962 no 3078 0.0887975844016863 4374 763655
SGTC_546 peri-Naphthalide 147 µM -1.34848972026372 0.0886056254712939 no 3079 0.0887504621346385 4343 223824 A penicillin ester.
SGTC_3247 9135149 49.47 µM -1.34992684660641 0.0883757197222938 no 3080 0.088519724601419 4447 8934436 YOR116C RPO31
SGTC_426 0988-0037 14.6 µM -1.35122171979313 0.0881689520298865 no 3081 0.0883122094987082 4432 5383008
SGTC_1158 4092-0494 91.8 µM -1.35592862644026 0.0874203822775594 no 3082 0.0875609391523833 4478 1148199
SGTC_694 1315-0438 43.2 µM -1.3574654767292 0.0871769972589183 no 3083 0.0873166778805273 4417 6793154
SGTC_1005 4092-0690 4.4 µM -1.35989849415792 0.0867927248454315 no 3084 0.0869310237962698 4418 1529343
SGTC_1086 cerivastatin 2.18 µM -1.36004001918278 0.0867704113025961 no 3085 0.0869086300925919 4415 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_753 1322-0200 289 µM -1.36024065738897 0.0867387850268603 no 3086 0.086876890213198 4459 5403907
SGTC_53 0973-0023 39.979 µM -1.36135346739977 0.0865635309547063 no 3087 0.0867010068924575 4300 674768
SGTC_3117 9124945 49.47 µM -1.36661703657321 0.0857381683816776 no 3088 0.0858726871833462 4313 17592065
SGTC_1341 1486-1360 280 µM -1.36675461120756 0.0857166750433975 no 3089 0.0858511169783971 4397 3976547
SGTC_2003 4023581 200 µM -1.36801392676327 0.0855201191052842 no 3090 0.0856538584298689 4432 16641307
SGTC_1660 st012960 28.1 µM -1.37030397021137 0.0851635508504796 no 3091 0.085296017121958 4442 24207266
SGTC_3245 9134821 49.47 µM -1.37351931059063 0.0846647921861929 no 3092 0.0847954810962668 4427 17014901
SGTC_2755 lomerizine 42.69 µM -1.37817375003873 0.083946688045297 no 3093 0.0840748248871518 4354 3949 A calcium channel blocker.
SGTC_2365 9042475 200 µM -1.38000779656444 0.0836649841953787 no 3094 0.0837921221537329 4464 6464479
SGTC_1636 st007707 68.9 µM -1.3806118876492 0.0835723533427301 no 3095 0.0836991631254859 4434 403051
SGTC_1780 st038448 24.544 µM -1.38261490572381 0.0832657634945536 no 3096 0.0833914880768377 4451 728868 YDL195W SEC31
SGTC_2610 ononetin 44.17 µM -1.38419206290632 0.0830249532298157 no 3097 0.0831498265216194 4394 259632
SGTC_968 1309-0633 340 µM -1.38420553714145 0.0830228981580459 no 3098 0.0831477641890437 4457 3761976
SGTC_725 1497-0963 19 µM -1.38697973244993 0.0826005960765829 no 3099 0.08272397154346 4515 3549977
SGTC_45 0kpi-0036 14.9 µM -1.39006111486051 0.0821334299547585 no 3100 0.0822551599536036 4415 2795021
SGTC_2936 9038235 15.59 µM -1.39150408755337 0.0819153473898752 no 3101 0.0820363105013777 4352 4749415
SGTC_1079 idarubicin 2.36 µM -1.39370134138973 0.0815841056697815 no 3102 0.0817039055033654 4445 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1962 st076595 64.5 µM -1.39518725853937 0.0813606729056109 no 3103 0.0814796891227196 4399 279619
SGTC_3330 9141424 71.43 µM -1.39541529038096 0.0813264253541064 no 3104 0.0814453215343771 4447 27261020
SGTC_384 k007-0144 5.16 µM -1.39845272487691 0.080871277022714 no 3105 0.0809885798248884 4367 6824886
SGTC_911 3456-4043 236 µM -1.40531936079413 0.0798494282687895 no 3106 0.0799631668500888 4428 914281
SGTC_3081 9117243 49.47 µM -1.40954823746574 0.0792249906780881 no 3107 0.0793365602430569 4413 45595589
SGTC_1830 st055982 50.3 µM -1.41091256994146 0.0790243236427007 no 3108 0.0791351976543323 4434 455313 An antimicrobial agent.
SGTC_3314 9135860 59.4275 µM -1.41130047916817 0.0789673400083795 no 3109 0.0790780166345313 4432 25252478
SGTC_3291 9121177 71.43 µM -1.41407711312495 0.0785603625145477 no 3110 0.0786696311124103 4432 17015612
SGTC_3103 9120822 49.47 µM -1.41672393553774 0.0781738937833497 no 3111 0.0782818280857295 4455 17141819
SGTC_2508 celastrol 40.54 µM -1.42006741488708 0.0776877679895945 no 3112 0.077794027806853 4371 122724 Celastrol is a natural product and antioxidant.
SGTC_2026 5148700 152 µM -1.42037616616505 0.0776429930423311 no 3113 0.0777490988488704 4431 79838
SGTC_1220 1838-0075 193 µM -1.42047946591262 0.0776280169422986 no 3114 0.0777340712443766 4377 5529645
SGTC_541 4513-1321 94 µM -1.42406665704646 0.0771093156496962 no 3115 0.0772135886507926 4397 747515
SGTC_1642 st009582 77.7 µM -1.425054949093 0.076966874220655 no 3116 0.0770706589344105 4431 6739311
SGTC_1409 3909-8004 61.9 µM -1.42587641819074 0.0768486290813297 no 3117 0.0769520087415801 4492 2119279
SGTC_1723 st034307 2.5525 µM -1.43230100994284 0.075928609955072 no 3118 0.0760288470956263 4450 867466
SGTC_99 0109-0120 622.8 µM -1.43273600759026 0.0758666215775068 no 3119 0.0759666475646615 4467 759414
SGTC_2021 4019055 173 µM -1.43394822050799 0.0756940812055828 no 3120 0.0757935198513633 4247 44827708 YER133W GLC7
SGTC_2105 5350118 200 µM -1.43683132790724 0.0752849151042912 no 3121 0.0753829632178544 4423 2133313
SGTC_563 tetrahydrosecaminediol 614 µM -1.43919055387307 0.0749513535691178 no 3122 0.0750482705019132 4496 334274 A psychoactive constituent of the cannabis plant.
SGTC_3133 9127736 49.47 µM -1.44276833410182 0.0744476581691159 no 3123 0.0745428711052553 4473 27243420
SGTC_805 3852-0218 479 µM -1.44659324449223 0.0739120332366473 no 3124 0.0740054396876908 4439 6615355
SGTC_1561 5-methoxyflavone 52.9 µM -1.45183900480816 0.0731822334652694 no 3125 0.073273187838701 4431 94525
SGTC_1793 st048256 72.231 µM -1.45411584655767 0.0728671962179455 no 3126 0.0729570954402124 4428 672022
SGTC_722 3534-0461 190 µM -1.45797350777029 0.0723357986337789 no 3127 0.0724239226874164 4498 658262
SGTC_869 0564-0080 44.1 µM -1.45845255087957 0.0722700176610224 no 3128 0.0723579223766907 4467 6843321
SGTC_478 N-arachidonylglycine 10 µM -1.46359893535041 0.0715662181508395 no 3129 0.0716517818171791 4500 5283389
SGTC_1625 st003711 30.1 µM -1.46708351391931 0.0710926747258916 no 3130 0.0711766691435058 4490 24207034 YER133W GLC7
SGTC_184 1494-0393 24.714 µM -1.46919285570308 0.0708071930702756 no 3131 0.0708902437650368 4465 3090647
SGTC_741 4582-0002 126 µM -1.47532648470403 0.0699820617009378 no 3132 0.0700623946668745 4496 2912688
SGTC_1679 SEC14.276 6.7 µM -1.47755139400521 0.0696845893921759 no 3133 0.0697639462322487 4454 1005053 YMR079W SEC14
SGTC_1739 st037196 92.5 µM -1.47865422945902 0.0695375006248424 no 3134 0.0696163755307178 4500 612214
SGTC_936 3005-4620 401 µM -1.47978173025936 0.0693873694281852 no 3135 0.0694657529270331 4505 777207
SGTC_1488 4013-0813 75.9 µM -1.48470313110399 0.0687349869789484 no 3136 0.0688112409683655 4470 2910057
SGTC_1207 2099-0101 141 µM -1.48544171287259 0.0686374898630005 no 3137 0.0687134264257676 4481 5837381
SGTC_2491 paeonol 100 µM -1.48814437147619 0.0682816321509296 no 3138 0.0683564119620322 4464 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1271 0832-2808 169 µM -1.4890768509884 0.0681591839576556 no 3139 0.068233566407107 4525 3663794
SGTC_3265 9137266 49.47 µM -1.49017440734596 0.0680152759983306 no 3140 0.0680891918859042 4457 17224265
SGTC_1771 st048882 4.1505 µM -1.4954275383279 0.0673297490726727 no 3141 0.0674014489954427 4524 4580403
SGTC_1860 st056228 74.6 µM -1.49753935832221 0.0670556691864998 no 3142 0.0671264862127661 4479 688679
SGTC_2894 9048625 32.47 µM -1.49841309986588 0.066942524418126 no 3143 0.0670129774850432 4504 4092861
SGTC_249 wiskostatin 11.211 µM -1.50029045783636 0.0666999163873456 no 3144 0.0667695900627264 4460 2775510 A n-wasp and actin depolymerizer.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.5011486871208 0.0665892356348475 no 3145 0.0666585542060036 4575 4620898
SGTC_644 1498-1197 63.3 µM -1.51021048825004 0.0654292470481144 no 3146 0.0654948616443762 4544 6741615
SGTC_3339 9145883 14.936 µM -1.51178093398825 0.0652298195450828 no 3147 0.0652948006390081 4421 2030670
SGTC_3028 9087778 49.47 µM -1.51588831057735 0.0647104623883444 no 3148 0.0647737982916817 4481 17217395
SGTC_898 1000-0849 28.3 µM -1.51744455992521 0.0645145234408619 no 3149 0.0645772404001585 4502 6751807
SGTC_1559 coumarin 343 70.1 µM -1.51799449480954 0.0644453944287637 no 3150 0.0645078932480497 4543 108770 A hepatotoxic, DNA x-linker.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.52021605153618 0.0641667215690453 no 3151 0.0642283422388509 4439 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3098 9119039 49.47 µM -1.52418865196641 0.0636707334159355 no 3152 0.0637307959911447 4495 17161528
SGTC_659 k018-0002 107 µM -1.52446081758656 0.0636368624038237 no 3153 0.0636968188050912 4479 6797879 YHR007C ERG11
SGTC_2428 5615643 7.78 µM -1.52467103087383 0.0636107109568731 no 3154 0.0636705854024292 4497 2253075
SGTC_2109 5483026 200 µM -1.52581045085972 0.0634691076322798 no 3155 0.0635285386128572 4517 759335
SGTC_1293 1000-1278 195 µM -1.52825879925713 0.0631656651034592 no 3156 0.0632241475154832 4523 678847
SGTC_1329 1447-1697 50.6 µM -1.53263274549282 0.0626263817974676 no 3157 0.0626831842826502 4512 2840515
SGTC_102 gallobenzophenone 83.616 µM -1.53429490216534 0.0624223906452544 no 3158 0.0624785596559631 4489 70837
SGTC_1811 st050069 61.5 µM -1.53469991644552 0.0623727631318029 no 3159 0.0624287781946139 4510 3877702
SGTC_3042 9091578 49.47 µM -1.53607814777355 0.062204115124035 no 3160 0.0622596075149613 4500 25236497
SGTC_1920 st075728 45.7 µM -1.53624717713882 0.0621834562665042 no 3161 0.0622388846834405 4484 3400306
SGTC_3148 9097893 49.47 µM -1.53801772419124 0.0619673806040846 no 3162 0.0620221405809811 4488 17174100
SGTC_2490 carminic acid 95.39 µM -1.5392276312938 0.0618200621515271 no 3163 0.0618743671042149 4508 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_338 4055-0136 114 µM -1.53923895561776 0.0618186845927886 no 3164 0.0618729852933281 4490 2900563
SGTC_1292 0kpi-0043 232 µM -1.55049786575632 0.0604608981611414 no 3165 0.0605110326803672 4534 3333905
SGTC_1008 4106-0037 6 µM -1.55266412735343 0.0602023514070302 no 3166 0.0602516983339223 4549 2905394
SGTC_2940 9060638 45.86 µM -1.55356739981798 0.060094800429935 no 3167 0.0601438202790353 4498 4027022
SGTC_230 MPP+ 141.667 µM -1.55615292416865 0.0597877783528787 no 3168 0.0598358662824965 4491 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2791 5663188 71.43 µM -1.55669352371623 0.0597237396206417 no 3169 0.0597716335036032 4519 54690634
SGTC_2481 5478948 45.16 µM -1.56685136717209 0.0585304194472672 no 3170 0.0585747187233613 4524 77792
SGTC_995 3931-2021 34.6 µM -1.5692603641417 0.0582501808494973 no 3171 0.0582936419167019 4540 730143
SGTC_2340 7987427 183.45 µM -1.57098572311174 0.0580501184584413 no 3172 0.058092982531649 4526 2239331
SGTC_651 3253-0966 34.4 µM -1.57456494252848 0.0576368156360842 no 3173 0.0576784501286458 4558 781462
SGTC_2782 7736369 71.43 µM -1.59110276573882 0.0557571179144216 no 3174 0.0557932251050162 4516 2950836 YOL077C BRX1
SGTC_761 k216-0224 480 µM -1.59208449471705 0.0556470732944113 no 3175 0.0556828602581414 4540 1340404
SGTC_378 3970-0959 8.33 µM -1.59229259390128 0.0556237689352102 no 3176 0.0556594881324496 4551 6615653
SGTC_2455 5377712 9.75 µM -1.59597355985373 0.0552128212922264 no 3177 0.0552473483014759 4543 2243908
SGTC_935 2996-0153 430 µM -1.59683451557629 0.0551170500200726 no 3178 0.0551512999557221 4555 23738523
SGTC_1650 st011916 45.8 µM -1.60005591169423 0.0547598710436975 no 3179 0.0547930902051616 4507 242528
SGTC_669 0108-0021 26.2 µM -1.60045294526749 0.0547159760677936 no 3180 0.0547490688349069 4547 17201
SGTC_3031 9088762 49.47 µM -1.60262123992555 0.0544767457624132 no 3181 0.0545091507602209 4526 205253
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.60288888543033 0.0544472735917366 no 3182 0.0544795939867709 4592 91467 include heat shock
SGTC_1842 st055362 61.2 µM -1.60419594253111 0.054303526255606 no 3183 0.0543354344121622 4507 676032
SGTC_245 methotrexate 289.6 µM -1.60718396578736 0.053976037669604 no 3184 0.0540070091600759 4495 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1163 k060-0048 49.9 µM -1.6089211975794 0.0537863562985213 no 3185 0.0538167868740632 4554 6809982
SGTC_359 0081-0058 15.9 µM -1.61071483498768 0.0535910704782122 no 3186 0.0536209453922017 4544 3494159
SGTC_2141 5621638 7.665 µM -1.61157386482972 0.0534977410442507 no 3187 0.0535273508455461 4554 2856238
SGTC_1893 st059353 36.1 µM -1.61172694791462 0.0534811228357054 no 3188 0.0535106854613636 4550 3112488
SGTC_3142 9086498 49.47 µM -1.62028520659833 0.0525585544866052 no 3189 0.05258551260899 4416 25236367
SGTC_571 k831-0106 44.2 µM -1.62030219216282 0.0525567361068222 no 3190 0.052583689124062 4454 4783639
SGTC_2663 amphotericin b 100 µM -1.62051826091969 0.052533609348244 no 3191 0.0525604974463572 4589 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2035 5154463 94.595 µM -1.62054291188297 0.0525309713641531 no 3192 0.0525578520583363 4566 2769623
SGTC_383 2324-0395 7.37 µM -1.6237470538569 0.0521889792283668 no 3193 0.0522149020766359 4537 3146421
SGTC_1791 st048313 56.1 µM -1.62465935887125 0.0520919290152594 no 3194 0.0521175807766626 4570 1204976
SGTC_1967 st070177 51.4 µM -1.63711863777706 0.0507808198751224 no 3195 0.050802841497882 4570 5729214
SGTC_2063 5246145 200 µM -1.63993952081285 0.050487653036153 no 3196 0.0505088712684655 4596 711240
SGTC_3034 9090421 49.47 µM -1.64147913376641 0.0503282149144354 no 3197 0.0503489975217789 4504 17173761
SGTC_1831 st055328 12 µM -1.64285075643458 0.0501865116198564 no 3198 0.0502069078295525 4557 1103068
SGTC_2857 9024691 58.44 µM -1.65330531184459 0.0491168680175082 no 3199 0.0491343712406457 4576 16478292
SGTC_3159 9100096 49.47 µM -1.65610825531485 0.0488332057756889 no 3200 0.0488499489281947 4521 25236875
SGTC_477 mead ethanolamide 10 µM -1.66013375513129 0.0484281108436182 no 3201 0.0484437738173505 4584 16061185
SGTC_2678 equilin 100 µM -1.66858737789615 0.0475861529929706 no 3202 0.0475995910266026 4587 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2850 9015429 58.44 µM -1.68002012378769 0.0464661786927429 no 3203 0.0464767002090789 4561 6457570
SGTC_1611 st001856 99.4 µM -1.68812954335751 0.0456846658637787 no 3204 0.0456931821974307 4571 647478
SGTC_113 0099-0221 2.5 µM -1.69070703726864 0.0454384948741447 no 3205 0.0454463847982553 4544 89219
SGTC_893 0958-0369 48.9 µM -1.69411255869735 0.0451148778699159 no 3206 0.0451219481628913 4451 6819948
SGTC_2915 7971052 15.16 µM -1.69836200677847 0.0447136688528817 no 3207 0.0447197291253347 4555 5741558
SGTC_1735 st034310 56.75 µM -1.70388002070889 0.0441969824794295 no 3208 0.0442017521474372 4585 871153
SGTC_2159 5658611 73.75 µM -1.70493946747362 0.0440983327091362 no 3209 0.0441028572742623 4572 793844
SGTC_2766 oltipraz 83.91 µM -1.70938833027212 0.0436860158354128 no 3210 0.0436895205604947 4556 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2528 xanthyletin 44.79 µM -1.714049679111 0.0432573488079636 no 3211 0.0432598011877076 4609 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1223 0764-0573 147 µM -1.72097921676377 0.0426263793143621 no 3212 0.0426272976576252 4596 1609797
SGTC_2858 9025781 8.96 µM -1.72609165866112 0.0421656524888677 no 3213 0.0421654621212783 4420 4894980 YPL153C RAD53
SGTC_844 0330-0132 15.3 µM -1.72633111935172 0.0421441717777923 no 3214 0.0421439299562705 4640 2828079
SGTC_2311 7694451 200 µM -1.72868424463923 0.041933556522861 no 3215 0.0419328113349007 4591 2163142
SGTC_1170 0310-0127 64.8 µM -1.72958585314949 0.0418530846639503 no 3216 0.0418521476940002 4615 774975
SGTC_1530 rhein 70.4 µM -1.7341853823427 0.0414445039018715 no 3217 0.0414425978722535 4664 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2878 9043973 25.97 µM -1.73505069347045 0.0413679998868202 no 3218 0.0413659132812776 4609 6465167
SGTC_863 0466-0191 129 µM -1.7359264972928 0.0412906847783261 no 3219 0.0412884159641913 4643 765160 YPR165W RHO1
SGTC_2645 abamectin 100 µM -1.73835597021255 0.0410768262487416 no 3220 0.0410740549153842 4562 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1568 digitonin 820 nM -1.74322335442925 0.0406510689856491 no 3221 0.0406473037481841 4580 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2029 5175081 200 µM -1.74426319638282 0.0405605783839776 no 3222 0.0405566030308153 4559 1380876
SGTC_2942 9052777 62.25 µM -1.74588846137502 0.0404194698447383 no 3223 0.040415167638525 4609 6469503
SGTC_367 0335-0881 7.1 µM -1.75334648813256 0.0397770530490423 no 3224 0.0397712751697469 4529 23828853
SGTC_702 1488-0190 94 µM -1.75352225111817 0.0397620139460434 no 3225 0.0397562017661452 4648 949357
SGTC_500 h-89 112 µM -1.75563479706095 0.0395816160800417 no 3226 0.0395753933381726 4593 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2583 asiatic acid 100 µM -1.75930739114389 0.0392695849596134 no 3227 0.0392626559436386 4584 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_235 0330-0087 5 mM -1.76043944455174 0.0391738079964322 no 3228 0.0391666631816112 4650 46494818 YHR062C RPP1
SGTC_480 am 92016 50 µM -1.76084543623502 0.0391395055747377 no 3229 0.039132283585413 4623 2129 K+ channel blocker.
SGTC_2176 5809774 33.9695 µM -1.76344044079421 0.0389208296373516 no 3230 0.0389131170794577 4549 2870539
SGTC_588 3970-1144 52.9 µM -1.76499330683809 0.0387904491827379 no 3231 0.0387824453033544 4537 1888707
SGTC_3202 9113761 49.47 µM -1.77320412239395 0.0381069612167446 no 3232 0.0380974446085146 4551 4798415
SGTC_3141 9094609 49.47 µM -1.7732518670073 0.0381030157544029 no 3233 0.0380934904850187 4562 25236309 YDL196W YDL196W
SGTC_551 k048-0028 34.9 µM -1.77597383740568 0.0378786312144621 no 3234 0.0378686147297475 4577 6836383
SGTC_1865 st057639 52.2 µM -1.7870321700719 0.0369781052967352 no 3235 0.0369661446142765 4627 688818
SGTC_1435 4092-0789 56.7 µM -1.79919071279331 0.0360082636183449 no 3236 0.035994259018894 4641 2248285
SGTC_1472 k841-0093 193 µM -1.80058750566984 0.0358981931873624 no 3237 0.0358839599669124 4665 X1472
SGTC_2999 9069765 71.4286 µM -1.80121470021222 0.0358488585935601 no 3238 0.0358345231276806 4591 2097066
SGTC_1813 st051246 8.6015 µM -1.81694910536046 0.0346292714280942 no 3239 0.0346124533368925 4597 5291959
SGTC_606 k015-0008 38.6 µM -1.81890559457263 0.0344800329335727 no 3240 0.0344629170870464 4684 1970475
SGTC_1247 0448-0043 5.84 µM -1.82223027256297 0.0342276428735894 no 3241 0.034210026524569 4594 3089013 YGL099W LSG1
SGTC_2122 5258151 111.688 µM -1.82695346653719 0.0338716987281715 no 3242 0.0338533831164623 4643 2173356
SGTC_1103 duloxetine 36.1 µM -1.83376413281308 0.0333638068456501 no 3243 0.0333445070138806 4681 60835 A selective serotonin reuptake inhibitor.
SGTC_1428 4049-0204 61.7 µM -1.83693998396465 0.0331291270392908 no 3244 0.0331093778897369 4681 X1428
SGTC_2389 9091542 195.52 µM -1.84602480439629 0.0324653030555612 no 3245 0.0324443019690309 4613 3626624 YOL127W RPL25
SGTC_1262 0737-0114 49.6 µM -1.84735118075556 0.0323693096342293 no 3246 0.0323481298653103 4660 765919
SGTC_1321 1326-2144 215 µM -1.85189926412207 0.0320419294358995 no 3247 0.0320201448222809 4624 3513030
SGTC_2625 euphol 100 µM -1.85325602825586 0.0319447979416991 no 3248 0.0319228352351474 4639 6708538 A triterpene alcohol.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.86865179494167 0.0308595466859001 no 3249 0.0308356373446736 4616 6708760
SGTC_2046 4110841 106 µM -1.86932457785183 0.0308128266845951 no 3250 0.0307888353510581 4659 44119630 YMR134W ERG29
SGTC_2675 theaflavin digallate 100 µM -1.87651269986915 0.030317307791072 no 3251 0.0302924562383912 4605 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2073 5212005 126 µM -1.87666481468567 0.0303068934093052 no 3252 0.0302820239630909 4608 691789
SGTC_1009 4106-0057 9.87 µM -1.87853574390333 0.0301790445022188 no 3253 0.0301539560204487 4644 2928005
SGTC_1390 3413-2614 145 µM -1.89094346874139 0.0293424381718364 no 3254 0.0293159454829689 4651 3421432
SGTC_2833 9001315 45.46 µM -1.89308492773321 0.0292000147452491 no 3255 0.0291732881125541 4590 2989378
SGTC_2620 irigenin 100 µM -1.90238122973594 0.0285883805740226 no 3256 0.0285606665569085 4628 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_439 amiodarone 34.4 µM -1.91558967376263 0.0277377120589101 no 3257 0.0277086724894586 4545 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1565 sinapyl alcohol 95.1 µM -1.93276860909719 0.0266629863290571 no 3258 0.0266323544905412 4664 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2852 9023854 51.95 µM -1.93440049185239 0.0265627285584664 no 3259 0.0265319530198432 4667 19798528
SGTC_875 0709-0210 25.7 µM -1.9581682252509 0.0251378630162399 no 3260 0.0251051381353423 4670 6251364
SGTC_845 0330-0138 4.51 µM -1.95871518498587 0.0251058421949819 no 3261 0.0250730755515922 4651 9039800
SGTC_585 0kpi-0023 191 µM -1.9587450292814 0.02510409599585 no 3262 0.0250713270776619 4633 64601
SGTC_1555 citronellol 128 µM -1.9599017071548 0.025036496798226 no 3263 0.0250036400282752 4668 8842 A terpine precursor.
SGTC_2721 ifenprodil 61.44 µM -1.96265227635917 0.0248763592209567 no 3264 0.0248432959817263 4647 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2740 felodipine 17.08 µM -1.97334382561666 0.024262035027206 no 3265 0.0242282014872572 4723 3333 L-type calcium channel blocker
SGTC_1285 0929-0069 65.5 µM -1.97637809767039 0.0240900280788893 no 3266 0.0240559851442486 4693 1206237
SGTC_528 3492-0019 172 µM -1.98349189925372 0.0236907736780155 no 3267 0.0236562555171963 4675 2869262
SGTC_1404 3909-7820 48.3 µM -1.98872032609365 0.0234008941766536 no 3268 0.0233660405856457 4667 23741373
SGTC_2475 5812728 15.03 µM -1.98902826437729 0.0233839146409409 no 3269 0.0233490416559588 4647 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2295 7971645 200 µM -1.99119225583075 0.0232648856090122 no 3270 0.0232298774634241 4701 2978226 YKL099C UTP11
SGTC_1815 st051655 58.2 µM -2.00330624628475 0.0226079425003908 no 3271 0.0225722137301528 4671 5984156
SGTC_3259 9138485 49.47 µM -2.00390398133737 0.0225759362641502 no 3272 0.022540173497433 4652 17646153
SGTC_341 1486-1430 230 µM -2.04450096982142 0.0204897850159537 no 3273 0.020452040847533 4670 2054753 YPL210C SRP72
SGTC_2315 7733312 200 µM -2.04540426290355 0.0204452907064159 no 3274 0.0204075095151871 4625 726316
SGTC_139 0099-0334 718.624 µM -2.04877542259132 0.020279956814962 no 3275 0.020242040054431 4677 97690
SGTC_2516 gossypol 71.55 µM -2.05230761043768 0.0201079428646916 no 3276 0.0200698884307139 4703 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_135 0933-0004 26.348 µM -2.05406730865793 0.0200227101664375 no 3277 0.0199845888006828 4635 21230617 YGL099W LSG1
SGTC_1446 4239-0190 62 µM -2.06516284593498 0.0194923157677724 no 3278 0.0194537973356097 4701 1340085
SGTC_621 3584-0052 32.1 µM -2.09298376609326 0.0182146338017712 no 3279 0.018175301871641 4724 2273927
SGTC_3311 9131146 2.8755 µM -2.09407944208709 0.0181658108782027 no 3280 0.0181264520295925 4678 4900406 YPR165W RHO1
SGTC_1752 st044819 83.042 µM -2.1073050626046 0.0175852268686556 no 3281 0.0175455724063098 4655 441209 YML126C ERG13
SGTC_2044 5102272 200 µM -2.12142409193958 0.0169829768496341 no 3282 0.0169430648090116 4712 592666
SGTC_1560 lithocholic acid 53.1 µM -2.12513293991597 0.0168277309382089 no 3283 0.0167877608475365 4678 9903 A bile acid which acts as a detergent.
SGTC_2873 9040596 71.43 µM -2.13264329267951 0.0165170752437641 no 3284 0.016476999521098 4684 6463863
SGTC_668 1682-0499 62.6 µM -2.15052777024273 0.0157970109291415 no 3285 0.0157567458950808 4721 682214
SGTC_2447 5741742 33.78 µM -2.15104806924546 0.0157764721500907 no 3286 0.0157362028833486 4741 1776504
SGTC_3219 9131112 49.47 µM -2.15151451008767 0.0157580788938776 no 3287 0.0157178058925753 4592 17612988 YMR079W SEC14
SGTC_2949 9072542 2.23 µM -2.15167325640704 0.0157518232147411 no 3288 0.0157115489553527 4668 16457352
SGTC_1986 st071812 45 µM -2.15568754327742 0.0155943396585609 no 3289 0.015554035754193 4683 11838594
SGTC_263 alizarin 107.927 µM -2.15864189609473 0.0154793029577926 no 3290 0.0154389798798068 4732 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1998 st075797 76.8 µM -2.16846817553893 0.015101912753322 no 3291 0.0150615417235152 4712 24208315
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.18121782340069 0.0146240526160978 no 3292 0.0145836545696131 4677 279621
SGTC_1059 3448-6867 171 µM -2.1960319776934 0.0140852089801311 no 3293 0.0140448273192365 4694 3934407
SGTC_2188 6126565 140.678 µM -2.23449125235028 0.0127655016528869 no 3294 0.0127253837420139 4691 874518
SGTC_1075 aripiprazole 15.2 µM -2.24550128561585 0.0124079731240287 no 3295 0.0123679848983043 4765 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2905 7799065 20.05 µM -2.25279802828564 0.0121758332502061 no 3296 0.0121359432906516 4670 1296806
SGTC_2567 aureobasidin a 60 nM -2.26012291055548 0.0119465935731838 no 3297 0.0119068117962251 4736 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2275 7947463 200 µM -2.26050675252993 0.0119346847603823 no 3298 0.0118949089105289 4705 1225414
SGTC_2896 9052656 71.43 µM -2.2642531285252 0.0118189919759944 no 3299 0.0117792753039869 4386 6469436
SGTC_1381 2324-0066 62.1 µM -2.27089298103086 0.0116163345934549 no 3300 0.011576728634784 4745 10885928
SGTC_1495 4469-0029 237 µM -2.27398338330064 0.0115230447461842 no 3301 0.0114834928109496 4737 793680
SGTC_2522 biochanin a 4.94 µM -2.28109135633928 0.0113109425700448 no 3302 0.0112715207576262 4724 5280373 A possible chelator.
SGTC_2175 5807670 165.306 µM -2.28458499252449 0.0112079417878726 no 3303 0.0111685868711882 4713 241186
SGTC_699 0375-0592 111 µM -2.29488366535692 0.0109090428725248 no 3304 0.0108698960835511 4770 762578
SGTC_2950 9072895 21.46 µM -2.29568044961223 0.0108862095656513 no 3305 0.010847079544632 4679 17332245
SGTC_2269 7935389 174.42 µM -2.29649691160698 0.0108628555136867 no 3306 0.0108237427721264 4731 97605
SGTC_532 1548-0774 215 µM -2.30088681832392 0.0107380328504522 no 3307 0.0106990146907849 4753 5932993
SGTC_2532 xanthone 78.9 µM -2.30835886668127 0.0105284432064432 no 3308 0.0104895924039292 4744 7020 An insecticide.
SGTC_1955 wogonin 32.4 µM -2.32667374109054 0.0100297264422483 no 3309 0.00999131823635761 4712 5281703 A flavanone.
SGTC_2523 spermine 47.74 µM -2.33913735654311 0.00970224520589616 no 3310 0.00966416293508992 4735 1103 A DNA binding polyamine.
SGTC_1129 3453-1384 223 µM -2.34988399597274 0.00942741757250375 no 3311 0.00938963134868668 4703 1084452
SGTC_1507 4075-3230 155 µM -2.35843749210287 0.00921356630046581 no 3312 0.00917602511491929 4725 659771
SGTC_1878 temozolomide 1 mM -2.4038628085121 0.00814754549039096 no 3313 0.00811143010603395 4740 5394 DNA alkylating agent.
SGTC_1861 st057647 17.4 µM -2.40450642714226 0.0081332545518319 no 3314 0.00809716072475332 4749 688668
SGTC_293 4049-0273 38.5 µM -2.41448388826515 0.0079145152555152 no 3315 0.00787875992996682 4692 1380311
SGTC_402 epigallocatechin gallate 10 µM -2.43110609267598 0.00756157747350229 no 3316 0.0075264030791866 4745 65064 An antioxidant.
SGTC_1818 st052136 56.3 µM -2.44455913907388 0.00728615506912617 no 3317 0.00725146506550357 4532 674169
SGTC_1619 st003326 88.7 µM -2.4619577547644 0.00694309377852596 no 3318 0.00690904707567088 4733 2849032
SGTC_808 0711-0032 135 µM -2.5117472846208 0.0060388749850185 no 3319 0.00600675424368842 4751 4252555
SGTC_286 k060-0067 22.9 µM -2.51956084299098 0.00590687595649689 no 3320 0.00587506655908664 4777 5985051
SGTC_1245 0418-0076 17.2 µM -2.55006989044189 0.00541564295943676 no 3321 0.0053850662885816 4752 6790114
SGTC_3329 9141233 27.5565 µM -2.55247719092802 0.00537847407239124 no 3322 0.00534799563211864 4738 4909101 YNL103W MET4
SGTC_158 k038-0087 26.446 µM -2.55579361545827 0.00532763973023128 no 3323 0.0052972968087767 4711 X158
SGTC_1124 fisetin 1.16336 µM -2.56783326736538 0.00514666754512994 no 3324 0.00511681827985556 4755 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2722 naftopidil 47.16 µM -2.62562317444493 0.0043519837785029 no 3325 0.0043245254607607 4745 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1800 st050079 29.0735 µM -2.63185857136541 0.00427315991387767 no 3326 0.0042459602280888 4682 3645560
SGTC_971 1315-0384 26.7 µM -2.65983585422211 0.00393497863439235 no 3327 0.00390893710380098 4782 6769120
SGTC_1553 gossypol 38.6 µM -2.67680162250915 0.00374177404598772 no 3328 0.00371643147762032 4780 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1683 st010134 710 nM -2.68105828897495 0.00369465432639719 no 3329 0.00366948656280011 4751 3818134
SGTC_645 0845-0943 5.41 µM -2.71200678434184 0.00336776676264559 no 3330 0.00334386120160076 4782 1885106
SGTC_3318 9139014 38.6185 µM -2.72294085009529 0.00325864604033049 no 3331 0.00323518207039417 4776 16643984
SGTC_3201 9113999 49.47 µM -2.74603236398927 0.00303858097251148 no 3332 0.00301604063763213 4746 16649224
SGTC_1527 coumarin 137 µM -2.7508325728669 0.00299455084186069 no 3333 0.00297220084316323 4770 323 A hepatotoxic, DNA x-linker.
SGTC_1128 3448-9350 235 µM -2.79064223123227 0.00265097566238476 no 3334 0.00263017911925242 4747 619386
SGTC_2436 5633522 8.09 µM -2.82262627734271 0.00240118764257193 no 3335 0.00238160299148483 4771 5724242
SGTC_2036 5160441 105 µM -2.86012545377292 0.00213557730395841 no 3336 0.00211736724435187 4780 134534 YIL048W NEO1
SGTC_2110 5483698 200 µM -2.94943564599573 0.00160693546332788 no 3337 0.00159177433446317 4781 2848765 YHR062C RPP1
SGTC_2177 5811945 192 µM -2.96926663526935 0.00150708727791121 no 3338 0.00149255726188393 4779 5343475
SGTC_1314 1222-0010 41.1 µM -3.00181023263946 0.00135542893683998 no 3339 0.00134189710433087 4786 3526027
SGTC_3106 9121286 49.47 µM -3.06338788203775 0.00110600307946952 no 3340 0.00109423097038176 4783 15943471
SGTC_1908 st060353 56.5 µM -3.16427453864968 0.000786602127235639 yes 3341 0.00077735033156368 4787 4227716
SGTC_535 2293-4129 48.2 µM -3.18453674362752 0.000733728105328639 yes 3342 0.000724929516273599 4785 396118 YIL048W NEO1
SGTC_394 menadione 8.33 µM -3.21557554417999 0.000659053647625617 yes 3343 0.000650916126767201 4795 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1787 fluconazole 80 µM -3.22978892121301 0.000627256157804514 yes 3344 0.000619408207266237 4590 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1540 guanosine 70.6 µM -3.27200247538511 0.000540978450563634 yes 3345 0.000533943205360051 4803 6802 Guanosine is a purine nucleoside
SGTC_352 k048-0007 5.11 µM -3.28548933789532 0.000515817120433355 yes 3346 0.000509026976704269 4767 6811911
SGTC_1731 st035964 63 µM -3.29510058219572 0.00049855195658151 yes 3347 0.000491932288258579 4767 6739575
SGTC_1556 plumbagin 1.48 µM -3.32802782923217 0.000443377131800915 yes 3348 0.000437315644667973 4786 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2077 5212015 200 µM -3.33351113522284 0.000434758536587211 yes 3349 0.000428786194323966 4803 780900
SGTC_649 1123-0311 367 µM -3.35335920822884 0.000404843616799758 yes 3350 0.000399185099062602 4772 693629 YIL048W NEO1
SGTC_1058 3448-5425 97.3 µM -3.42097766030407 0.000316671326646399 yes 3351 0.000311982287067831 4799 7279705
SGTC_3293 9120939 62.045 µM -3.4226283902438 0.00031476121918819 yes 3352 0.000310094004791081 4790 934087
SGTC_1754 st042065 16.137 µM -3.67218170290986 0.000122456675389927 yes 3353 0.000120244294371738 4753 1126236 YIL048W NEO1
SGTC_1310 1188-0297 994 nM -4.55286123245795 2.73255153425263e-06 yes 3354 2.6460591352012e-06 4804 1588352
SGTC_2005 4024620 188 µM -4.84217084340385 6.66700890700019e-07 yes 3355 6.42141337235071e-07 4808 236743
SGTC_151 3013-0144 2.285 µM -5.83360230170477 2.87677591007316e-09 yes 3356 2.71216617254352e-09 4795 906558 YHR107C CDC12