SGTCid condition conc unit PRP42|YDR235W.score PRP42|YDR235W.strain.pval PRP42|YDR235W.strain.significant PRP42|YDR235W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3335 9143315 29.6265 µM 5.46188769638635 2.33435424805732e-09 yes 1 2.35549040198759e-08 4 4899691
SGTC_2804 7954240 19.48 µM 4.79774483001998 1.28610343573935e-07 yes 2 8.02310073291413e-07 6 828705
SGTC_2243 6634756 200 µM 4.01643310095566 7.74605138679477e-06 yes 3 2.95428132539509e-05 4 885676
SGTC_2835 9006588 71.43 µM 3.74902551311582 2.70430402773816e-05 yes 4 8.87615135925356e-05 10 2345538
SGTC_1694 st024011 44.9 µM 3.74099391738274 2.8044312163718e-05 yes 5 9.16469786918448e-05 8 2787533
SGTC_2240 6690706 185.951 µM 3.73151165583194 2.92716387097832e-05 yes 6 9.51671008816103e-05 7 805876
SGTC_2344 7990960 76.95 µM 3.48102187120567 8.76261737110775e-05 yes 7 0.000249752351056374 49 140813
SGTC_2225 6654152 15.4 µM 3.47258745972231 9.08151540766856e-05 yes 8 0.000257733514646856 30 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1024 4507-0395 26 µM 3.43424897370074 0.000106735066572218 yes 9 0.000297099074321359 16 4201836
SGTC_920 mycophenolic acid 780.421 nM 3.39708568623509 0.000124638681539526 yes 10 0.00034053818412283 7 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_836 0330-0104 1.35 µM 3.34801241431396 0.000152615186192236 yes 11 0.000406966826413562 7 46494820
SGTC_678 1218-2179 85.9 µM 3.23212001017925 0.000243699199421571 yes 12 0.000614377195908239 4 6820081 YOR116C RPO31
SGTC_2540 epiandrosterone 100 µM 3.17444768259191 0.000305973466361664 yes 13 0.000750609755224857 10 441302 A steroid.
SGTC_132 0417-1715 25.805 µM 3.08634765909322 0.000430217823001229 yes 14 0.00101315874744095 17 6769098
SGTC_693 4161-2696 114 µM 3.07579759432644 0.000447890645161492 yes 15 0.00104970153611152 10 805759
SGTC_127 0180-0333 59.125 µM 3.04751115660314 0.00049864930766937 yes 16 0.00115372480208012 5 771601
SGTC_2811 7967822 32.47 µM 3.0175243505103 0.000558237134915923 yes 17 0.00127424282666128 18 2232244
SGTC_2450 5739737 12.93 µM 2.96207735187009 0.00068608189743278 yes 18 0.00152785503392564 12 2262825
SGTC_214 4373-3496 70 µM 2.95058277207965 0.000715756092719326 yes 19 0.00158587523468999 36 3779166
SGTC_124 0136-0217 7.121 µM 2.92947724255803 0.000773342463026498 yes 20 0.00169766337267404 41 3976905
SGTC_847 0342-0274 5.54 µM 2.85254696837908 0.00102126970017064 no 21 0.00216852013300604 18 18097
SGTC_2546 rhodinyl acetate 100 µM 2.83361240068621 0.00109256967757699 no 22 0.00230125593936113 18 6708682
SGTC_2927 9011802 47.9 µM 2.83142597504058 0.00110109029558768 no 23 0.00231704794366246 19 43912568
SGTC_2165 5727197 32.143 µM 2.81817610525458 0.0011540418324634 no 24 0.0024148655971003 7 1361712
SGTC_3198 9112019 49.47 µM 2.78315253725028 0.00130543476375008 no 25 0.00269167449534353 19 45595555
SGTC_1451 4152-0210 104 µM 2.75897048866427 0.00142033449245596 no 26 0.0028991885512565 16 659563
SGTC_2059 5238311 157 µM 2.75465821266167 0.00144176885231828 no 27 0.00293767379995489 18 703021
SGTC_22 0964-0034 14.468 µM 2.72452932826439 0.00159995607319 no 28 0.00321966055061089 57 138402
SGTC_2714 st079313 56.9 µM 2.7044840379761 0.00171379775384079 no 29 0.00342052781753669 19 2939799
SGTC_999 SEC7.066 22.7 µM 2.69491370432304 0.00177070909491328 no 30 0.00352034315123439 28 740511 YDR170C SEC7
SGTC_2242 6630449 61.2675 µM 2.6249813512286 0.0022415846430418 no 31 0.00433268565917449 16 691249 YDR170C SEC7
SGTC_1282 0886-0010 32.4 µM 2.62438814820053 0.00224602361707734 no 32 0.00434023993132013 43 2836211 YNL267W PIK1
SGTC_3193 9111931 49.47 µM 2.59740069653171 0.00245659309411449 no 33 0.00469661381519706 25 17087244
SGTC_1740 st038286 13.222 µM 2.59454728154296 0.00247986969868908 no 34 0.00473577925559746 36 716786
SGTC_1226 3909-7979 35.4 µM 2.58091302423506 0.00259386749443806 no 35 0.00492697021947112 37 6615510
SGTC_2833 9001315 45.46 µM 2.57180937857424 0.00267259872355474 no 36 0.00505842890827943 29 2989378
SGTC_3138 9097216 49.47 µM 2.54080269139783 0.00295720872389802 no 37 0.00552991568800508 30 25237486
SGTC_2241 6772625 37.8075 µM 2.53861127502662 0.00297832157628927 no 38 0.00556467022538801 27 2285411
SGTC_2321 7390090 138.78 µM 2.52831038128611 0.00307939500054488 no 39 0.00573064892754479 17 649046
SGTC_1170 0310-0127 64.8 µM 2.49209955508792 0.00345967348214145 no 40 0.00634952186508119 36 774975
SGTC_446 go6976 132 µM 2.48804052214312 0.00350482868100753 no 41 0.00642245482570039 18 3501 A protein kinase C inhibitor.
SGTC_566 0958-0068 16.5 µM 2.48239487249161 0.0035685144208035 no 42 0.00652512846364388 43 6815365
SGTC_632 0781-2353 4.65 µM 2.47183057139106 0.00369048188474031 no 43 0.00672116036484526 46 6811515 YHR007C ERG11
SGTC_75 0159-0059 199.013 µM 2.45617136944706 0.00387815560590547 no 44 0.00702130872771043 39 5377270
SGTC_3099 9120367 49.47 µM 2.38681672923231 0.00481624022387563 no 45 0.00849748054119606 25 24824940
SGTC_2293 7624732 200 µM 2.37803396041157 0.00494843784210866 no 46 0.00870261142354919 39 894453
SGTC_5 0352-0601 109.883 µM 2.3736219461463 0.00501605929920403 no 47 0.00880728771146247 27 762456
SGTC_2198 6589944 200 µM 2.36226347311877 0.0051939482409701 no 48 0.0090818640057372 26 5290268
SGTC_2490 carminic acid 95.39 µM 2.35488617627483 0.0053124728224615 no 49 0.00926419009465668 38 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_300 r073-0011 5.04 µM 2.33925207783634 0.00557163287355375 no 50 0.00966119563892342 28 2735780
SGTC_1812 st052057 4.327 µM 2.33488663773591 0.00564597461986901 no 51 0.00977467179159343 42 3645418
SGTC_1749 st037932 54.2 µM 2.30728296779067 0.00613677941023205 no 52 0.0105195252003907 46 594497
SGTC_2245 6637752 200 µM 2.28641959796648 0.00653245013207002 no 53 0.0111148614432577 31 681890
SGTC_2885 9057732 51.95 µM 2.28017799083984 0.006655126665366 no 54 0.0112985670649799 27 6471414
SGTC_2904 7225135 42.03 µM 2.27823986829245 0.00669363191570533 no 55 0.0113561450606691 34 4446116
SGTC_3325 9138760 55.175 µM 2.27736690204115 0.00671103961622348 no 56 0.0113821624299914 29 43844959
SGTC_2395 5646831 180.19 µM 2.2763789093292 0.00673078929632741 no 57 0.0114116704427031 37 6808628
SGTC_459 nigericin 15.3 µM 2.27344402704571 0.00678975993534997 no 58 0.0114997177712978 47 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_625 k213-0058 121 µM 2.24837333445412 0.0073123939791584 no 59 0.0122761970281316 73 3655420
SGTC_533 1222-0222 6.71 µM 2.24509953085681 0.00738319468241688 no 60 0.0123808718639136 44 3982874
SGTC_2384 9036245 200 µM 2.22924178374988 0.00773475984732476 no 61 0.0128989108956667 28 6462766
SGTC_1594 piperine 70.1 µM 2.20046254225519 0.00841056054525008 no 62 0.0138870473616613 21 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2796 7949634 45.45 µM 2.19986864202895 0.00842503612904389 no 63 0.0139081080574126 45 2971588
SGTC_2718 lomofungin 53.02 µM 2.19539167577994 0.00853486219188474 no 64 0.0140677568612617 36 5351222 A RNA synthesis inhibitor.
SGTC_1373 2887-0003 58.5 µM 2.18640926325641 0.00875900731211039 no 65 0.0143928382534598 59 776948
SGTC_2265 7929201 200 µM 2.18423584707083 0.00881401152773518 no 66 0.0144724610437937 46 1265108
SGTC_1425 4048-4433 7.33 µM 2.18038052998728 0.00891232596104331 no 67 0.0146146330757843 38 23734946
SGTC_2830 7992007 71.43 µM 2.16023759328602 0.00944177094674031 no 68 0.0153771406542908 47 1952075
SGTC_2234 tolnaftate 200 µM 2.1599471745202 0.00944960139999357 no 69 0.0153883796088302 13 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2185 6113692 200 µM 2.15436716467607 0.00960115984681079 no 70 0.0156056947359489 47 874150
SGTC_3163 9099914 49.47 µM 2.14018544345361 0.00999594761906814 no 71 0.0161698915425186 20 16268368
SGTC_1879 gemcitabine 100 µM 2.13793272883979 0.0100599451897023 no 72 0.0162611017302867 33 60750 A nucleoside analog which inhibits DNA replication.
SGTC_835 0312-0010 67.2 µM 2.13130964187512 0.0102501764684944 no 73 0.0165318206304758 46 1626196
SGTC_2505 galangin 7.89 µM 2.12613022626514 0.0104011205779224 no 74 0.0167462088856113 53 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_52 0329-0193 875 nM 2.1235647366859 0.0104766017853304 no 75 0.0168532784362708 41 3739292
SGTC_2623 humulene 100 µM 2.12252935875955 0.0105071993584597 no 76 0.0168966549885618 31 6187145 An anti-inflammatory.
SGTC_573 3702-0553 84.7 µM 2.12231090152803 0.0105136651632202 no 77 0.0169058193126377 51 1222756
SGTC_661 1304-0007 33.6 µM 2.11704945657022 0.0106704418998095 no 78 0.0171278253196068 36 3117130
SGTC_3109 9122853 49.47 µM 2.10946475014041 0.0109000271321483 no 79 0.0174522427879407 32 1234709
SGTC_2805 7950783 58.44 µM 2.09858160167113 0.0112369594108437 no 80 0.0179268998062015 49 1178958 YDL195W SEC31
SGTC_1078 idebenone 36.1 µM 2.0910052344206 0.0114768289782029 no 81 0.0182637973795012 54 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1111 tnp00062 510.699 nM 2.08855411416289 0.0115553784120542 no 82 0.0183739396846909 34 676306
SGTC_2596 sinensetin 100 µM 2.07072126840564 0.0121410381632685 no 83 0.0191924257414023 59 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2765 myclobutanil 7.74 µM 2.0647193724872 0.0123438549615074 no 84 0.0194747802505337 60 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3315 9136395 68.55 µM 2.06172499185743 0.0124461342917736 no 85 0.0196169628985611 68 16876844
SGTC_1071 trifluoperazine 6.31 µM 2.04267488680514 0.0131141747075452 no 86 0.0205423162135223 45 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1676 st018489 23.4 µM 2.03847708570069 0.0132654793110177 no 87 0.0207511220342435 42 3696235
SGTC_152 4469-0003 551.229 µM 2.03024396947827 0.0135666153668787 no 88 0.0211658732320287 88 697280
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.02926662333519 0.0136027517605175 no 89 0.0212155704616938 36 61125 An anti-inflammatory.
SGTC_3134 9127454 49.47 µM 2.02895947731304 0.0136141253177439 no 90 0.0212312089468008 22 24262820
SGTC_1990 st072050 59.8 µM 2.02634068050826 0.0137114325727951 no 91 0.0213649426042591 38 17233948
SGTC_2725 haloperidol 53.21 µM 2.02342864440575 0.0138203397998782 no 92 0.0215144867174972 70 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_703 3875-0075 71.8 µM 2.02100802290844 0.0139114356415736 no 93 0.0216394672930686 53 2850814
SGTC_3272 9137413 49.47 µM 2.01736334092734 0.0140495733226684 no 94 0.0218288049855688 59 17614870
SGTC_480 am 92016 50 µM 2.01302718491097 0.0142154571502963 no 95 0.0220558847668527 55 2129 K+ channel blocker.
SGTC_2253 7938677 135.83 µM 2.00520199192021 0.0145190895552652 no 96 0.0224707286141961 39 2301972
SGTC_2648 atorvastatin 78.68 µM 2.00128423063681 0.0146731919110497 no 97 0.0226808840822187 40 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2712 st079126 47.7 µM 1.99721936889813 0.0148345657122429 no 98 0.0229006789428034 39 3152970
SGTC_378 3970-0959 8.33 µM 1.9902662673919 0.0151141406533692 no 99 0.0232808059194926 51 6615653
SGTC_2858 9025781 8.96 µM 1.9792245897176 0.0155674137218412 no 100 0.0238953627831202 61 4894980 YPL153C RAD53
SGTC_1744 st037937 38.9 µM 1.97020920742985 0.0159461092012386 no 101 0.0244071993720071 53 1016152
SGTC_1473 k844-0725 134 µM 1.96972404604916 0.0159667106730384 no 102 0.0244350027860121 72 54682906
SGTC_2113 5491891 107.031 µM 1.92699655018142 0.0178727991961558 no 103 0.0269900299331302 65 789979
SGTC_195 4234-0266 16.654 µM 1.92198691435641 0.0181085038968891 no 104 0.0273037021614989 77 2303354
SGTC_2719 novobiocin 32.65 µM 1.92150650312543 0.0181312459728298 no 105 0.0273339416535745 35 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_88 0180-0332 8.668 µM 1.91459140333549 0.0184613048908412 no 106 0.0277723161614245 62 3101745
SGTC_1998 st075797 76.8 µM 1.9082682651521 0.0187675744128328 no 107 0.0281782762268299 55 24208315
SGTC_521 r062-0005 13.8 µM 1.90567026271811 0.018894659553902 no 108 0.0283464998955874 51 2832033
SGTC_1093 fluphenazine 7.97 µM 1.89516999006083 0.0194157804145777 no 109 0.0290349422849652 52 6602611 An atypical antipsychotic.
SGTC_2878 9043973 25.97 µM 1.89466311714397 0.019441242094804 no 110 0.0290685235202418 36 6465167
SGTC_1889 st059080 5.18 µM 1.89217470393513 0.0195666540599537 no 111 0.0292338537835448 47 176925 Isolated from Daphnopsis sellowiana.
SGTC_2028 5153890 36.43 µM 1.8758602364043 0.0204060101847519 no 112 0.0303372370092303 76 2830968 YPR165W RHO1
SGTC_2956 9076196 2.52 µM 1.86697088273638 0.0208760624204921 no 113 0.0309528270535908 54 16423868
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.86093372485179 0.0212004956758354 no 114 0.0313767682509933 72 4330530
SGTC_2784 7567673 72.73 µM 1.86031983440477 0.02123372338918 no 115 0.0314201444979478 67 3471247
SGTC_2663 amphotericin b 100 µM 1.86025514680857 0.0212372272632438 no 116 0.031424718077472 82 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1697 st025554 27.742 µM 1.8598064769811 0.0212615434139898 no 117 0.031456455339321 48 1269519
SGTC_344 k064-0035 6.43 µM 1.8561677294981 0.0214596205022156 no 118 0.0317148271269716 57 5088750
SGTC_2205 7238770 200 µM 1.85268481630676 0.0216506735733841 no 119 0.0319637737841294 50 279867
SGTC_2486 5283202 22.39 µM 1.84137222209459 0.0222811622530157 no 120 0.0327835153002245 55 1377751
SGTC_2789 5281112 71.43 µM 1.84045064797318 0.0223332001429925 no 121 0.0328510517402874 67 765948
SGTC_1513 0337-0559 19 µM 1.8376450781494 0.0224922518671774 no 122 0.0330573608692048 56 775073
SGTC_2432 5630864 12.22 µM 1.83732429085876 0.0225104984550066 no 123 0.0330810180039875 69 5714970
SGTC_2070 5230947 200 µM 1.83529182138692 0.0226263969227665 no 124 0.033231231119807 53 2835538
SGTC_1880 MG-132 525 µM 1.83516148381267 0.0226338463558802 no 125 0.0332408830782777 79 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2689 tacrolimus 100 µM 1.82422367295338 0.0232664049187895 no 126 0.0340591320493519 71 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1505 k297-0037 20.6 µM 1.82081579820849 0.0234665050739433 no 127 0.0343174309982868 59 4089396
SGTC_3241 9133421 49.47 µM 1.8186364791238 0.0235952256260355 no 128 0.0344834542874786 41 17018221
SGTC_1033 k072-0102 21.3 µM 1.8186332608716 0.0235954161489769 no 129 0.034483699945096 61 5965931
SGTC_1458 k015-0034 6.33 µM 1.81798721700419 0.0236336886398624 no 130 0.034533043287549 45 3598957
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.81768925523906 0.0236513578725264 no 131 0.034555820457635 60 803109
SGTC_1023 4482-3888 16 µM 1.81471608113293 0.0238282773649011 no 132 0.0347837762304327 69 3303168
SGTC_81 0411-0046 9.971 µM 1.81339411155021 0.0239072980676803 no 133 0.0348855285579513 113 12925265
SGTC_628 1636-0253 16 µM 1.81161288522081 0.0240141190439668 no 134 0.0350230162854041 71 4456143
SGTC_8 0354-0001 70 µM 1.80622739758252 0.0243395314691005 no 135 0.0354414135245453 78 4993152
SGTC_2575 plumbagin 510 nM 1.7903033948028 0.025323453257823 no 136 0.0367025754125459 92 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2405 ticlatone 3.52 µM 1.79001992836123 0.0253412657592622 no 137 0.0367253538834475 71 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_12 0849-0099 9.267 µM 1.78881287818257 0.0254172320850959 no 138 0.0368224781115896 68 6071388
SGTC_27 0485-0001 32.618 µM 1.78520475065999 0.0256454495507073 no 139 0.0371140558429457 52 2054479
SGTC_896 0964-0007 44.5 µM 1.77437505624137 0.026340762304014 no 140 0.038000566487368 75 6756758
SGTC_79 0052-0007 94.094 µM 1.76550504356527 0.0269219299894566 no 141 0.038739461668749 61 2801472
SGTC_1888 azatryptophan 97.5 µM 1.76169751134935 0.0271746648349323 no 142 0.0390602092794946 58 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.76151578574605 0.0271867766717474 no 143 0.0390755717929815 68 5379071
SGTC_1581 himbacine 57.9 µM 1.75996914819157 0.0272900409690438 no 144 0.0392065188625515 66 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1930 st074634 34.3 µM 1.75456305857469 0.0276535628683874 no 145 0.0396670374573043 85 684253 YOR116C RPO31
SGTC_2484 5809818 12.04 µM 1.74449994003723 0.0283409868069387 no 146 0.0405359759281875 63 2870548
SGTC_3092 9117248 49.47 µM 1.74270764516397 0.0284649004290286 no 147 0.0406923477707114 52 17141857
SGTC_1141 3253-0389 52.6 µM 1.73890187533999 0.0287295144884251 no 148 0.0410260121563427 78 5402031
SGTC_3290 9121031 71.43 µM 1.73475076597888 0.0290204688930468 no 149 0.0413924800716617 67 17014854
SGTC_1011 4112-3381 17.4 µM 1.7344102189653 0.0290444463833582 no 150 0.0414226615948536 70 2877139
SGTC_636 0kpi-0074 126 µM 1.73398884635879 0.0290741374863998 no 151 0.0414600310986569 57 616434
SGTC_2227 7312221 64.1025 µM 1.73230396693988 0.0291931109845443 no 152 0.0416097280235054 62 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_688 0527-0193 473 µM 1.72029186860786 0.0300530847032374 no 153 0.0426897003930303 56 4007154
SGTC_2251 lansoprazole 556 µM 1.7197833413487 0.0300899499351229 no 154 0.042735915910963 54 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1575 cyproterone acetate 48 µM 1.71876392066544 0.030163964850681 no 155 0.0428286837882262 76 9880 An androgen receptor antagonist and liver toxin.
SGTC_2154 5570129 200 µM 1.71769466360033 0.0302417602355878 no 156 0.0429261616179068 62 673366
SGTC_736 0958-0254 92.6 µM 1.71639534404794 0.0303365179002188 no 157 0.0430448540824552 68 6812352
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.71442107783693 0.0304809693743518 no 158 0.0432257100919063 75 15053
SGTC_2657 nystatin 74.44 µM 1.7128732364122 0.0305946186298529 no 159 0.0433679314893953 63 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_174 3553-0389 74.3 µM 1.7061623001759 0.0310914315046912 no 160 0.0439889328810992 74 738071
SGTC_171 k064-0041 9.68 µM 1.70368416232497 0.0312765682559732 no 161 0.0442200542624782 81 53325
SGTC_3256 9138902 49.47 µM 1.70202826289139 0.0314007846380779 no 162 0.0443750351259796 52 17228773
SGTC_2772 vinpocetine 57.06 µM 1.6940670128705 0.0320037010655637 no 163 0.0451262748855705 67 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3273 9137859 49.47 µM 1.68886249913725 0.0324029895816765 no 164 0.0456228916398564 82 2377234
SGTC_2317 5986382 200 µM 1.68237931592456 0.0329061171680894 no 165 0.046247654825412 78 877883
SGTC_1781 st038725 66.3 µM 1.68182955855519 0.0329490756477608 no 166 0.0463009476050339 83 4270275 YIL048W NEO1
SGTC_1661 st013063 9.66 µM 1.67220539067281 0.0337086323438382 no 167 0.0472419139351246 86 721395
SGTC_2951 9072950 58.06 µM 1.6562378556475 0.0350005641075102 no 168 0.0488368299195004 74 16488155
SGTC_1741 st038134 10.228 µM 1.65310172987766 0.0352590226876578 no 169 0.0491550806724404 73 1272587
SGTC_2683 piperine 63.03 µM 1.65214387745233 0.0353382738887805 no 170 0.0492526120540561 77 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2141 5621638 7.665 µM 1.65051990938439 0.0354729722350713 no 171 0.0494183223408565 66 2856238
SGTC_1628 st004252 77.7 µM 1.64437040227858 0.035986857069282 no 172 0.0500498574957317 73 692968
SGTC_2600 tangeritin 87.95 µM 1.64426301971118 0.0359958843990087 no 173 0.0500609422491564 100 68077 A bioactive flavone.
SGTC_1102 cgs 12066b 26.1 µM 1.64405312282023 0.0360135351559308 no 174 0.0500826148754465 76 6438352 A 5-HT1B full agonist.
SGTC_1940 st075990 51.1 µM 1.642528785132 0.0361419333274547 no 175 0.050240232869066 73 1084979
SGTC_2975 9084847 53.72 µM 1.63780167321243 0.036542493327563 no 176 0.0507315362192178 88 27211724
SGTC_1942 st076330 65.2 µM 1.63452590381766 0.0368221963224725 no 177 0.051074235830764 78 24208414
SGTC_2394 5221648 200 µM 1.6263271399416 0.0375299312519355 no 178 0.0519400406184632 100 788586
SGTC_774 k060-0086 136 µM 1.62536750031536 0.0376134907555654 no 179 0.0520421382574433 77 5911235
SGTC_2267 7931562 200 µM 1.62447672569486 0.0376911897939008 no 180 0.0521370518597741 76 934880
SGTC_2722 naftopidil 47.16 µM 1.61978190943293 0.0381028693620468 no 181 0.0526395668443543 77 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_59 0330-0160 1.33 µM 1.61875500657419 0.0381934036326254 no 182 0.0527499932168456 76 4293482
SGTC_1839 st053978 48 µM 1.61389011729619 0.0386246911759998 no 183 0.0532756313311226 67 3788398
SGTC_2903 5923464 63.88 µM 1.61264115438369 0.0387360534674535 no 184 0.0534112459774578 74 2876576
SGTC_3171 9103192 49.47 µM 1.60605098338438 0.0393279969746631 no 185 0.0541313542179901 68 13018434
SGTC_3352 9151559 45.5865 µM 1.60360137826183 0.0395498937049281 no 186 0.0544009733770967 73 17159339
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.59247566693274 0.0405705614192815 no 187 0.0556389331572907 60 364106
SGTC_2698 st077697 67.5 µM 1.59163106326737 0.0406489102476687 no 188 0.0557338130719713 79 3154499
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.58497992113417 0.0412701968403921 no 189 0.0564854481769821 79 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1414 3917-0015 5.4 µM 1.57852557767572 0.0418804379745732 no 190 0.0572224584132954 66 6618702
SGTC_2295 7971645 200 µM 1.57388525982216 0.0423236662889865 no 191 0.0577569891227455 70 2978226 YKL099C UTP11
SGTC_1234 0326-0494 15.5 µM 1.57278966531197 0.0424288658141065 no 192 0.0578837647211185 98 1547813
SGTC_2652 actinonin 100 µM 1.57253131140989 0.0424537038750797 no 193 0.0579136917283177 85 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2755 lomerizine 42.69 µM 1.5693519118811 0.042760334231575 no 194 0.0582829812477711 67 3949 A calcium channel blocker.
SGTC_1607 st000305 50.6 µM 1.56850510701793 0.0428423037019919 no 195 0.0583816495220432 87 5457690
SGTC_1465 k213-0056 144 µM 1.56088684333789 0.0435854643604177 no 196 0.059275226050288 112 24048857 YMR208W ERG12
SGTC_3220 9131269 49.47 µM 1.55926542821848 0.0437449682958004 no 197 0.0594667853513045 75 17722206
SGTC_455 paf C-16 10 µM 1.55894336556515 0.0437767066514424 no 198 0.0595048925922435 90 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_970 1315-0089 19.5 µM 1.55130166736947 0.0445352391131493 no 199 0.0604147037251755 84 6811083 YLR033W RSC58
SGTC_3268 9137683 49.47 µM 1.54769347707923 0.0448970582036204 no 200 0.0608480566585283 95 1953228
SGTC_1692 fluoroquinolonic acid 71 µM 1.54488636133491 0.0451801814089278 no 201 0.0611868764834117 74 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1816 st051957 91.6 µM 1.54244954878653 0.0454271193575718 no 202 0.0614821944305555 85 674121
SGTC_1189 1431-2119 7.28 µM 1.53944875717375 0.0457326990440323 no 203 0.0618473893512161 109 3107275
SGTC_187 1488-2104 32.728 µM 1.5375498888091 0.045926918615943 no 204 0.0620793539987899 80 2852859
SGTC_1734 st037168 69.4 µM 1.535445799184 0.046142902032669 no 205 0.0623371805498048 95 708907
SGTC_1909 st060837 51.5 µM 1.53400023869854 0.0462917600675051 no 206 0.0625147970294279 96 678937
SGTC_37 0566-0070 1.56 µM 1.53062465169107 0.0466408661485274 no 207 0.0629310927640627 89 1626686
SGTC_2593 nobiletin 86.24 µM 1.5264169318993 0.0470789865672828 no 208 0.0634530317573522 93 72344 An anti-infammatory.
SGTC_2128 5255449 168.493 µM 1.525872545523 0.0471359099910493 no 209 0.0635208046191787 90 736008
SGTC_1304 1165-0502 251 µM 1.52584363232291 0.0471389348242721 no 210 0.0635244057152174 94 767425
SGTC_2011 4012611 177 µM 1.52255140773384 0.0474843787736928 no 211 0.0639354873446289 86 2049887
SGTC_1842 st055362 61.2 µM 1.52121593282233 0.0476250833674485 no 212 0.0641028292167282 76 676032
SGTC_462 ag-879 158 µM 1.52017261687459 0.0477352385046075 no 213 0.0642337988276723 115 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_771 0250-0039 27.3 µM 1.52010597443928 0.0477422816570082 no 214 0.0642421716520608 111 3005115
SGTC_1018 4259-0013 28.1 µM 1.51949114668238 0.0478072994182128 no 215 0.0643194574191936 95 6801262
SGTC_1378 2093-0007 380 nM 1.51439068953806 0.0483494079020112 no 216 0.0649633896271659 105 3618014
SGTC_2 0422-0095 29 µM 1.51302183565647 0.0484957320639882 no 217 0.0651370562201498 89 6790840
SGTC_376 3970-0862 59.1 µM 1.51200538433615 0.0486046149489729 no 218 0.0652662463965551 122 3135186
SGTC_3184 9108758 49.47 µM 1.50727973060912 0.0491133988385051 no 219 0.0658694854247582 91 902885
SGTC_3141 9094609 49.47 µM 1.50527689539163 0.0493303120718511 no 220 0.0661264513694526 120 25236309 YDL196W YDL196W
SGTC_401 neomycin 50 µM 1.50005163331726 0.0498998260533269 no 221 0.0668005141047174 86 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1359 1582-0056 520 nM 1.4977144822207 0.0501562493886236 no 222 0.0671037237687173 88 3661189
SGTC_643 k048-0106 28.4 µM 1.49273363870667 0.0507062332164678 no 223 0.0677534621455189 104 6763920
SGTC_691 1548-0686 185 µM 1.48103942312286 0.0520163859865355 no 224 0.0692980342442956 123 46495133
SGTC_518 1021-0119 62.6 µM 1.47890660866347 0.0522582089518051 no 225 0.0695826384199211 112 1097762
SGTC_2721 ifenprodil 61.44 µM 1.4728528721973 0.052949459719031 no 226 0.0703953560412011 97 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_453 enantio-paf c16 10 µM 1.47136360827768 0.0531206191652235 no 227 0.0705964048085711 131 13871343 A lipid and platelet activating factor
SGTC_1014 4130-3005 69.3 µM 1.46988080815658 0.0532914712680093 no 228 0.0707970191341465 95 743608
SGTC_2614 arthonioic acid 13.39 µM 1.46978587496494 0.0533024245367489 no 229 0.0708098779526335 82 6710684
SGTC_1344 1488-0097 29.1 µM 1.4681471933509 0.053491774877898 no 230 0.0710321223267477 96 747966
SGTC_2138 5575593 77.673 µM 1.46736265740661 0.0535826167981947 no 231 0.071138713597992 79 762213
SGTC_3159 9100096 49.47 µM 1.46339136012039 0.0540443324153951 no 232 0.0716801607274559 89 25236875
SGTC_3053 9095903 49.47 µM 1.4599223596517 0.0544502212669996 no 233 0.0721557066385736 112 17174018
SGTC_2850 9015429 58.44 µM 1.45824515601761 0.0546473245169328 no 234 0.0723864906078421 106 6457570
SGTC_448 monastrol 171 µM 1.45799562926367 0.0546766967934271 no 235 0.0724208738764938 88 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1296 1068-0102 11.9 µM 1.45328370953657 0.0552336926175701 no 236 0.0730724992183073 83 767053
SGTC_2990 9074105 71.4286 µM 1.45316997266845 0.0552471926376119 no 237 0.0730882835052445 92 6502001
SGTC_225 nsc-122657 1.016 µM 1.45295220489154 0.0552730478986787 no 238 0.0731185123761098 89 275685
SGTC_1959 st077091 55.8 µM 1.44964950287168 0.0556663456982093 no 239 0.0735781420422695 143 821356 YKL052C ASK1
SGTC_2098 5376439 882.5 nM 1.44711303832183 0.0559698939921056 no 240 0.0739326334434459 89 2844116
SGTC_2155 5570423 76 µM 1.4420213702978 0.0565831731191294 no 241 0.0746481725106813 101 797402
SGTC_3046 9092212 49.47 µM 1.4398368452407 0.0568479116812471 no 242 0.0749567821122394 89 25236637
SGTC_2984 9022109 38.96 µM 1.43912567550298 0.0569343071938715 no 243 0.075057459323635 106 6459207
SGTC_2428 5615643 7.78 µM 1.43778683019548 0.0570972355443928 no 244 0.0752472736114486 139 2253075
SGTC_499 genistein 192 µM 1.43741384210725 0.0571426909602143 no 245 0.0753002189796803 79 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2893 9048488 25.97 µM 1.43724194333837 0.0571636495535257 no 246 0.0753246294336764 123 6467338
SGTC_2649 anisomycin 9.56 µM 1.4336284683326 0.0576056209460372 no 247 0.0758391575092621 106 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1109 tnp00067 928.257 nM 1.43255737802817 0.0577371432454259 no 248 0.0759921847942412 84 676295
SGTC_942 3253-1115 227 µM 1.43125127098264 0.0578978433092471 no 249 0.0761791070554725 118 46497897
SGTC_1838 st055369 84.5 µM 1.42984151519023 0.0580716903738883 no 250 0.0763812554054255 96 676036
SGTC_828 2074-0507 139 µM 1.42768097431923 0.0583389178536727 no 251 0.076691852387632 107 X828
SGTC_470 aa-861 153 µM 1.42446390474888 0.0587386112288608 no 252 0.077156113327241 113 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_133 0724-0033 378.92 µM 1.42396606179428 0.0588006555419131 no 253 0.077228148318683 111 280309
SGTC_3123 9126162 49.47 µM 1.42085754695144 0.0591892220640165 no 254 0.0776790884376529 92 25239884
SGTC_2356 9061756 188.97 µM 1.42064758442605 0.05921553995557 no 255 0.0777096187979014 99 20104043
SGTC_2285 7945142 200 µM 1.41876350107651 0.059452112455868 no 256 0.0779839884789206 109 2970608
SGTC_395 anisomycin 6.25 µM 1.4181996602342 0.0595230542532992 no 257 0.0780662405442782 106 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1386 3228-0095 33.8 µM 1.41474866522174 0.0599587011745458 no 258 0.078571100117213 92 870181
SGTC_719 2810-4230 27.3 µM 1.40948379943354 0.0606281336305899 no 259 0.0793460802710069 82 721079
SGTC_3210 9128157 49.47 µM 1.40752020434933 0.0608792982127152 no 260 0.0796365952038537 116 17590849
SGTC_1534 6-azauridine 81.6 µM 1.39861950316185 0.0620280071874858 no 261 0.0809635573320971 126 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2979 9012552 45.46 µM 1.3985132884514 0.0620418164851543 no 262 0.0809794925257624 107 17100905
SGTC_2541 muurolladie-3-one 83.07 µM 1.39820462173873 0.0620819607986886 no 263 0.0810258146495216 155 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1165 k072-0275 30.3 µM 1.3981820360743 0.0620848990214123 no 264 0.0810292049025641 106 6153523 YGL055W OLE1
SGTC_2402 5553605 200 µM 1.39291912242624 0.062772527022803 no 265 0.0818221245812576 102 6758546
SGTC_2943 9068529 45.32 µM 1.38940992110993 0.0632343110970768 no 266 0.082354067574885 140 3270634
SGTC_2160 5660466 132.927 µM 1.38832357740254 0.063377800510524 no 267 0.0825192679329608 125 2859134
SGTC_1955 wogonin 32.4 µM 1.38391353952363 0.0639629034248886 no 268 0.0831924652265274 81 5281703 A flavanone.
SGTC_853 0419-0306 21 µM 1.38039154433438 0.0644331948855003 no 269 0.08373306111908 138 762713
SGTC_1608 st001473 40.5 µM 1.37851060879756 0.064685454101048 no 270 0.0840228473515031 133 7292267
SGTC_2058 5236698 133 µM 1.37585953970572 0.0650423002932638 no 271 0.084432561875194 103 766665
SGTC_250 brefeldin a 552.239 µM 1.37467775868239 0.0652018650292877 no 272 0.0846156847750413 88 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2513 baicalein 25.65 µM 1.37456574175123 0.0652170053637299 no 273 0.0846330578053265 116 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1387 3342-1166 1.8 µM 1.37258181157245 0.0654856078146405 no 274 0.0849411947307738 85 3418228
SGTC_3346 9158254 43.5805 µM 1.37240981392684 0.0655089347695197 no 275 0.0849679483531014 131 17639500
SGTC_3221 9128209 49.47 µM 1.37228433369203 0.0655259569266592 no 276 0.0849874703422028 101 16460723
SGTC_1370 2001-0092 44.6 µM 1.37190965090544 0.0655768053383589 no 277 0.0850457828235887 119 790957
SGTC_2761 levamisole 97.89 µM 1.37162533481722 0.0656154104477418 no 278 0.0850900513981931 82 26879 An alkaline phosphatase inhibitor.
SGTC_539 4859-0462 2.54 µM 1.36935394025522 0.065924458770288 no 279 0.0854443322618176 132 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_568 1193-0097 7.48 µM 1.36323150203484 0.0667631025755313 no 280 0.0864047810076213 138 3646150
SGTC_2456 5770359 74.46 µM 1.36056690016248 0.0671306645829146 no 281 0.0868252988613729 127 3118787
SGTC_1864 st057645 30.4 µM 1.35794556661819 0.0674937830320081 no 282 0.0872404785491399 112 688666
SGTC_373 0844-0104 25.9 µM 1.34859788909861 0.0688010301108768 no 283 0.0887330795371205 138 5375804
SGTC_740 k014-0057 261 µM 1.34793357020739 0.0688946711426642 no 284 0.0888398747962114 128 4012779
SGTC_1446 4239-0190 62 µM 1.34637730787937 0.0691144233519978 no 285 0.0890904326738658 116 1340085
SGTC_3051 9093778 49.47 µM 1.34624813895342 0.0691326869141981 no 286 0.0891112524548551 143 17217378
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.33809076295464 0.0702936317533901 no 287 0.0904334257517618 166 16725076
SGTC_2743 auranofin 4.32 µM 1.33800617539627 0.0703057481766556 no 288 0.0904472118651001 88 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1426 4048-4480 71.7 µM 1.33244522716718 0.071105833754898 no 289 0.0913569643394418 113 14224343
SGTC_881 0833-0569 170 µM 1.3317945433979 0.0711999064617483 no 290 0.0914638557590048 109 5418700
SGTC_1865 st057639 52.2 µM 1.32954518074046 0.0715258446482521 no 291 0.0918340851095994 132 688818
SGTC_3122 9126309 49.47 µM 1.32736772603761 0.0718424526333886 no 292 0.0921935351686644 134 17591206
SGTC_1022 4477-0945 21.3 µM 1.32735828907946 0.0718438271287799 no 293 0.0921950952670528 108 4648966
SGTC_604 1000-0114 314 µM 1.32635516175909 0.0719900479238603 no 294 0.0923610416651598 114 1572745
SGTC_3243 9134147 49.47 µM 1.3257444559145 0.0720791791021676 no 295 0.0924621783423275 108 24282180
SGTC_787 4152-0075 138 µM 1.32509068577076 0.0721746891504054 no 296 0.0925705375211807 117 9566539
SGTC_1042 0350-0096 82 µM 1.32112573817245 0.0727560123385299 no 297 0.0932297211913525 121 3122515
SGTC_1574 spiramycin 23.7 µM 1.32110633179386 0.0727588664070708 no 298 0.0932329560637517 131 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3078 9116413 49.47 µM 1.31787174170368 0.0732357719460674 no 299 0.0937732933878501 121 17177322
SGTC_3330 9141424 71.43 µM 1.31662199688144 0.073420672563437 no 300 0.0939826808715729 93 27261020
SGTC_156 3474-0145 5.642 µM 1.3164258361289 0.073449727072965 no 301 0.0940155777688526 116 2265471
SGTC_2231 micatex 6.853 µM 1.3162140267566 0.0734811092628819 no 302 0.0940511085384431 124 20737 An antifungal of unknown mechanism.
SGTC_777 1315-0167 517 µM 1.31456331753719 0.0737260337873127 no 303 0.094328352591095 108 4221767
SGTC_804 1595-0054 20.9 µM 1.31260537902165 0.0740173520547434 no 304 0.0946579780653972 126 761523 Stimulates phospholipase C.
SGTC_2464 5717415 7.67 µM 1.31092082356986 0.07426869725961 no 305 0.0949422573968404 115 5285744
SGTC_1368 1852-0141 284 µM 1.31039291505491 0.0743475981861258 no 306 0.09503147458935 123 2838987
SGTC_2156 5649887 115 µM 1.30821029950425 0.0746744902237156 no 307 0.0954009948197543 135 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1051 3253-3903 78 µM 1.30683874868119 0.0748804689479988 no 308 0.0956337410450329 142 5509239
SGTC_163 TUB2.036 7.546 µM 1.30678308852405 0.0748888371012634 no 309 0.0956431951464313 167 15992207 YJR013W GPI14
SGTC_2136 5328288 199.296 µM 1.3040135979018 0.075306114007565 no 310 0.0961144730580752 98 262395
SGTC_3167 9103034 49.47 µM 1.3033836679198 0.075401271994498 no 311 0.0962219047357671 119 5127859
SGTC_307 1501-1223 22.3 µM 1.29947037231127 0.0759944733993235 no 312 0.0968912773852542 116 2830329
SGTC_2167 5876490 200 µM 1.29944379241297 0.0759985146579353 no 313 0.0968958355603243 112 686534
SGTC_1377 2944-0135 198 µM 1.29730038888829 0.0763249407329855 no 314 0.09726392532416 111 1894137
SGTC_2332 7982454 138.89 µM 1.29556617169338 0.0765898303892807 no 315 0.0975624950022569 139 2981748
SGTC_1076 itraconazole 331 nM 1.29313501583056 0.0769623490196984 no 316 0.0979821831752525 132 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_805 3852-0218 479 µM 1.29312268330485 0.076964242199669 no 317 0.0979843154950519 117 6615355
SGTC_3298 9116858 71.43 µM 1.29203792119805 0.0771309037853569 no 318 0.0981720062271685 138 2506942
SGTC_425 3825-7017 13.1 µM 1.28974985325043 0.0774833389573687 no 319 0.0985687620944172 148 3397440
SGTC_2822 7994718 71.43 µM 1.28918329638775 0.0775707953276511 no 320 0.0986671853292686 148 1018011
SGTC_3057 9095946 49.47 µM 1.28854303336655 0.0776697195159881 no 321 0.0987784994823497 147 24540043
SGTC_819 1013-0258 27.7 µM 1.28638511988767 0.0780038345249865 no 322 0.0991543444626323 124 5753198
SGTC_921 1561-0023 372 µM 1.28439806293623 0.0783124587611994 no 323 0.0995013551943548 141 24050882
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.28120637367405 0.078810120079038 no 324 0.10006059399811 138 279621
SGTC_422 cantharidin 155 µM 1.27741764811991 0.0794039798240584 no 325 0.100727418711647 126 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2759 disulfiram 3.38 µM 1.27078712621383 0.0804514151450791 no 326 0.101902194936012 146 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3088 9117578 49.47 µM 1.27048908470236 0.0804987412827933 no 327 0.101955234262551 133 678341
SGTC_190 3970-0790 3.722 µM 1.26974688409517 0.080616687026757 no 328 0.102087403235286 118 2832352
SGTC_752 1896-0090 130 µM 1.26881499001857 0.0807649624030668 no 329 0.102253528746919 139 772567
SGTC_161 4065-0411 162.148 µM 1.26645898553687 0.0811407489266805 no 330 0.10267440223611 140 1906281 YLR208W SEC13
SGTC_1393 3470-5649 58.2 µM 1.26542852123773 0.0813055237792858 no 331 0.102858878251216 93 4108395
SGTC_252 miconazole 1.30953 nM 1.26452059955391 0.0814509127107603 no 332 0.103021615884424 155 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_608 k048-0125 159 µM 1.25991486116398 0.0821914685664736 no 333 0.103850038535889 130 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_406 estrone 100 µM 1.25545572663093 0.0829132730234729 no 334 0.104656685233254 131 5870 A steroid.
SGTC_2945 9067681 61.76 µM 1.25257823878219 0.0833815798036189 no 335 0.105179619246081 158 16456930
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.24491233064163 0.0846388958857206 no 336 0.106581988916635 138 66535 A nucleotide analog.
SGTC_369 0957-0393 4.5 µM 1.23714579363051 0.0859271635212034 no 337 0.10801648071031 133 6997992
SGTC_1212 0520-0165 585 µM 1.23430162168334 0.0864025908733263 no 338 0.108545265937841 137 5403258
SGTC_648 0375-0473 33.3 µM 1.23211957348573 0.0867686699569288 no 339 0.108952210366013 150 1713139
SGTC_279 1273-0055 2.93 µM 1.23102581751913 0.0869526033347059 no 340 0.109156604208535 154 2847562
SGTC_430 0958-0115 16.4 µM 1.22845881013611 0.0873854323381778 no 341 0.109637391324235 138 6833180
SGTC_2023 5144124 124 µM 1.2284196260206 0.0873920517011222 no 342 0.109644742067691 129 2830192
SGTC_2807 7945238 51.95 µM 1.22583866660938 0.0878288772105209 no 343 0.110129696586037 152 17148797
SGTC_123 0083-0120 66.675 µM 1.22518860237587 0.0879391564314108 no 344 0.110252083912195 156 16001701
SGTC_609 0986-0026 86.3 µM 1.22466748181489 0.0880276357296014 no 345 0.110350265483843 145 2848610
SGTC_1863 st057641 20.1 µM 1.22463176684988 0.0880337020823588 no 346 0.110356996646624 140 3921635
SGTC_3182 9108849 49.47 µM 1.22354102817793 0.088219119271348 no 347 0.110562708858767 127 17133045
SGTC_3120 9124077 49.47 µM 1.22326835834446 0.0882655164941141 no 348 0.110614177031356 143 18774327 YGL155W CDC43
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.21959730479477 0.0888919510513663 no 349 0.111308784319341 158 616764
SGTC_2343 7990716 14.84 µM 1.21944134318885 0.0889186377043925 no 350 0.111338363111916 146 6456862
SGTC_3349 9149703 23.001 µM 1.21879914982401 0.089028586514237 no 351 0.111460217139985 125 4910494
SGTC_2376 9072922 81.32 µM 1.21874360202415 0.0890381015094241 no 352 0.111470761630973 136 17087968
SGTC_2366 9070441 60.58 µM 1.21843486029221 0.0890910008574725 no 353 0.111529382263176 126 6837235
SGTC_2492 derrusnin 100 µM 1.21662625498843 0.0894013545206069 no 354 0.111873224342413 156 1715307 Part of coumarin class of compounds.
SGTC_2170 morpholine 200 µM 1.21546980201527 0.0896002210025239 no 355 0.112093479770017 127 121171 Reacts with secondary amines.
SGTC_1914 st062367 72.6 µM 1.21122934431223 0.0903322351012183 no 356 0.112903759649714 147 978205
SGTC_503 tyrphostin 8 294 µM 1.21003600577241 0.090539035204573 no 357 0.113132538521394 153 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2972 9093619 59.92 µM 1.20985269046362 0.0905708340252386 no 358 0.113167711793313 107 25236256
SGTC_47 0149-0135 24.25 µM 1.2093848437531 0.0906520267114074 no 359 0.113257514345059 149 5239155
SGTC_1995 st072814 61.1 µM 1.20914680935347 0.0906933572375946 no 360 0.113303224237887 133 5769371
SGTC_3223 9129970 49.47 µM 1.20877319289478 0.0907582574263407 no 361 0.113374996572285 158 17248386
SGTC_598 3937-0236 20.2 µM 1.20816855933733 0.0908633601551306 no 362 0.113491216361035 149 1379313
SGTC_48 0382-0018 55 µM 1.20720800723636 0.0910305174293444 no 363 0.113676023763301 104 762596
SGTC_1521 st012942 49.4 µM 1.20615128920974 0.0912146730692213 no 364 0.113879580909863 131 24207259
SGTC_963 1269-2853 151 µM 1.20390573915108 0.0916069250177373 no 365 0.114313006653654 128 3668223
SGTC_755 1995-0008 37.3 µM 1.20141966637648 0.0920426477590144 no 366 0.114794225591537 105 689533
SGTC_1169 aniline yellow 25.8 µM 1.19996154807007 0.0922989184960312 no 367 0.115077137222556 146 6051 A DNA damaging agent.
SGTC_2222 6885208 172.143 µM 1.19776168174295 0.0926865535242414 no 368 0.115504904304429 129 609514
SGTC_1291 0993-0025 5.79 µM 1.19747489766755 0.0927371758849069 no 369 0.115560753005426 139 4353356
SGTC_100 0086-0128 49.5915 µM 1.19724416464322 0.0927779191042964 no 370 0.115605700177564 144 93297
SGTC_2065 5221596 34.26 µM 1.19668768785993 0.0928762371532318 no 371 0.115714153861834 146 788581
SGTC_1843 st055809 45.5 µM 1.19605830988244 0.0929875281580037 no 372 0.115836902576079 130 16413835
SGTC_548 1436-0017 110 µM 1.19523902306605 0.0931325478145506 no 373 0.115996828037041 137 9677137
SGTC_3008 9078912 71.4286 µM 1.19518127418488 0.0931427760841457 no 374 0.116008106576901 151 16648731
SGTC_2079 5212404 121 µM 1.19091396315495 0.0939008855461043 no 375 0.116843681192266 126 758462
SGTC_2647 atorvastatin 60.16 µM 1.1881434231152 0.0943955183167582 no 376 0.117388454568086 122 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2437 5741531 144.16 µM 1.18468066791796 0.0950164323448172 no 377 0.118071864416513 162 2262990
SGTC_466 geldanamycin 89.2 µM 1.18365857619112 0.0952002795925703 no 378 0.118274121414584 105 5288382 HSP90 inhibitor.
SGTC_1819 st053448 58.6 µM 1.18118290190633 0.0956466732720795 no 379 0.118765036044372 165 2857616
SGTC_259 usnic acid 108.925 µM 1.18058670889357 0.0957544037434988 no 380 0.118883473079756 166 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_589 1227-0070 34.1 µM 1.17501263446369 0.0967659455847446 no 381 0.119994830552767 144 2841384
SGTC_2468 5987765 72.9 µM 1.1694848828876 0.0977768091966377 no 382 0.121104164195632 133 26772094
SGTC_1067 clotrimazole 1.36 µM 1.16901632136156 0.0978628499412035 no 383 0.121198527795439 160 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1223 0764-0573 147 µM 1.1684862552639 0.0979602514968733 no 384 0.121305340128231 129 1609797
SGTC_1352 1496-0991 99 µM 1.16761472087716 0.0981205534840651 no 385 0.121481104768367 162 3000039
SGTC_2158 5657123 3.6195 µM 1.16745222087072 0.09815046347985 no 386 0.121513896365766 151 2858827
SGTC_555 4296-0685 37 µM 1.16627831515949 0.0983667327675178 no 387 0.121750968840218 166 2908540 YHR072W ERG7
SGTC_3102 9121669 49.47 µM 1.16601071908916 0.0984160809427764 no 388 0.12180505582575 154 41905072
SGTC_3016 9080866 49.47 µM 1.16236234990529 0.0990906967169143 no 389 0.122544154967147 152 17066299
SGTC_2905 7799065 20.05 µM 1.16006510789674 0.0995172088065581 no 390 0.123011149446921 142 1296806
SGTC_2112 5488546 200 µM 1.15513786039181 0.100436536726334 no 391 0.124016988155555 163 600757
SGTC_3022 9087993 49.47 µM 1.15451728681804 0.100552761570754 no 392 0.124144077746611 159 17173644
SGTC_1075 aripiprazole 15.2 µM 1.15090817662328 0.10123064303476 no 393 0.124885006789242 143 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1237 0330-0133 46.1 µM 1.14940545569225 0.101513871483524 no 394 0.125194415732901 176 X1237 YHR072W ERG7
SGTC_1358 1509-0022 2.48 µM 1.14776250268641 0.101824190408053 no 395 0.125533310432694 171 3258434
SGTC_979 1426-2828 121 µM 1.14604021607834 0.102150234484596 no 396 0.125889256154326 159 747872
SGTC_3280 9140961 49.47 µM 1.14493224589179 0.102360384102282 no 397 0.126118612546062 157 4901226
SGTC_2146 5545642 200 µM 1.14322009207963 0.102685747759754 no 398 0.126473611115788 148 825326
SGTC_960 1222-0186 7.7 µM 1.1428554157148 0.102755144856874 no 399 0.126549313079713 155 3126296
SGTC_975 1335-0046 28.5 µM 1.14157525788691 0.102999025846303 no 400 0.126815306667424 154 16486740
SGTC_982 1491-0518 27.5 µM 1.13944308826944 0.103406155241671 no 401 0.127259196442314 133 3091256
SGTC_1367 1812-0510 76.9 µM 1.13811953069233 0.103659470278425 no 402 0.127535286905572 143 1142582 YDR527W RBA50
SGTC_1002 4049-0206 172 µM 1.13772466357005 0.103735130832529 no 403 0.127617735700093 159 4662749
SGTC_623 k072-0108 16.9 µM 1.13721217928876 0.103833387760439 no 404 0.127724798363785 172 5382803
SGTC_556 4058-0063 51.5 µM 1.1366318440428 0.103944735015545 no 405 0.127846111073232 159 6615692
SGTC_2413 inermin 26.06 µM 1.13467297250594 0.104321217462572 no 406 0.128256182828332 189 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1249 0481-0015 10.2 µM 1.13381220497272 0.104486963586618 no 407 0.128436665148234 170 4227577
SGTC_2062 5245942 200 µM 1.13098693010213 0.105032328473177 no 408 0.129030296263622 142 1376160
SGTC_2357 9067248 200 µM 1.12778529652946 0.105652829069733 no 409 0.129705302235447 154 9150235
SGTC_258 haloperidol 50.781 µM 1.12567619936068 0.106063033399729 no 410 0.130151300776297 178 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2216 7189485 200 µM 1.12299921151661 0.106585343949193 no 411 0.130718914662843 148 731273
SGTC_1179 1021-1431 9.29 µM 1.11558136440109 0.108042344041181 no 412 0.132300686351828 180 2840958
SGTC_1209 2323-2347 50.3 µM 1.11274322264836 0.108603582603254 no 413 0.132909363226978 155 5412760
SGTC_3295 9122362 53.5725 µM 1.11201658972292 0.108747609822496 no 414 0.133065508744539 183 4730473
SGTC_1149 3909-7961 23.3 µM 1.11192598921191 0.10876557753884 no 415 0.133084986659271 149 735261
SGTC_2923 7992654 58.14 µM 1.10861328722375 0.109424012764926 no 416 0.133798521798227 161 2985126
SGTC_2826 7992541 19.48 µM 1.10753105905907 0.109639736434007 no 417 0.134032195759933 171 2985066
SGTC_2867 9039098 71.43 µM 1.10732340034798 0.10968116453735 no 418 0.134077065330649 162 6463460
SGTC_1283 0922-0125 16.4 µM 1.10702928244892 0.109739860557051 no 419 0.134140634109185 147 3360884
SGTC_119 0121-0043 24.815 µM 1.1065600259428 0.109833555020372 no 420 0.134242099098477 176 1092378
SGTC_2587 piperic acid 92.2 µM 1.10242556129212 0.110661548243618 no 421 0.135138351963985 132 5370536
SGTC_324 1315-0088 19.6 µM 1.10164656692703 0.110818053954595 no 422 0.135307677572903 165 6787421
SGTC_3145 9085516 49.47 µM 1.10119038747892 0.110909777361826 no 423 0.135406902215462 158 25236195
SGTC_567 1080-0542 68.4 µM 1.09830900554247 0.111490389849365 no 424 0.136034790424072 136 5950415
SGTC_1452 4194-0072 190 µM 1.09820318605691 0.111511754321335 no 425 0.136057887659152 162 1343545
SGTC_3169 9102970 49.47 µM 1.09795750074786 0.111561368362412 no 426 0.136111523779733 162 17027839
SGTC_1669 st015249 58.4 µM 1.09727344305912 0.111699591152536 no 427 0.136260938211026 150 722793
SGTC_1218 1348-1416 30.7 µM 1.09701076206375 0.111752701819602 no 428 0.136318343785872 159 6787668
SGTC_1262 0737-0114 49.6 µM 1.09444602241716 0.112272208025896 no 429 0.136879704350715 179 765919
SGTC_1514 1189-1591 158 µM 1.09234276516311 0.112699523903645 no 430 0.137341234946458 177 767698 YMR146C TIF34
SGTC_2521 angolensin 13.4 µM 1.09208430970199 0.112752113962914 no 431 0.137398022640231 132 821428 A flavenoid.
SGTC_1445 4239-0156 97.7 µM 1.08972833070951 0.113232312396549 no 432 0.1379164162609 169 4008346
SGTC_1214 0358-0031 63.7 µM 1.08421448003147 0.114361850512206 no 433 0.139134856453892 166 4301366
SGTC_2108 5365811 200 µM 1.08414520646779 0.114376092371137 no 434 0.139150210850508 156 780283
SGTC_3239 9133757 49.47 µM 1.08295997301209 0.114619958572423 no 435 0.139413094993142 162 17036923
SGTC_1625 st003711 30.1 µM 1.08028514614656 0.115171673451904 no 436 0.140007611077374 155 24207034 YER133W GLC7
SGTC_189 3970-0742 2.116 µM 1.0787266266278 0.115494005859835 no 437 0.140354806093203 159 2891807
SGTC_1417 3966-0327 90.4 µM 1.07791716279668 0.11566167154729 no 438 0.140535362730489 162 651118
SGTC_1860 st056228 74.6 µM 1.07433507733969 0.116405710665417 no 439 0.141336264478449 187 688679
SGTC_1840 st055363 71 µM 1.06903317583751 0.117513196512993 no 440 0.142527360294656 165 676033
SGTC_543 3844-1095 191 µM 1.06868205055753 0.117586803686596 no 441 0.142606481130514 199 4230703
SGTC_1929 genistein trimethyl ether 50.5 µM 1.06675139245715 0.117992114958234 no 442 0.143042056653627 166 136420
SGTC_3032 9089427 49.47 µM 1.06635126160503 0.118076239618676 no 443 0.143132442458111 149 17173707
SGTC_869 0564-0080 44.1 µM 1.065729800313 0.118206981521109 no 444 0.143272901213489 143 6843321
SGTC_2581 avocatin a 64 µM 1.06400371144024 0.118570649878569 no 445 0.143663509112284 163 6710728 A skin care supplement.
SGTC_2304 7443016 91.4 µM 1.06391005149261 0.118590405611684 no 446 0.143684724568622 154 939854
SGTC_1559 coumarin 343 70.1 µM 1.06356637662113 0.118662917026364 no 447 0.143762590462899 152 108770 A hepatotoxic, DNA x-linker.
SGTC_2558 carylophyllene oxide 100 µM 1.06266809820979 0.118852591285224 no 448 0.143966246483286 174 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2031 5180455 200 µM 1.06184459290282 0.119026665023961 no 449 0.14415312096909 171 29949
SGTC_1412 3909-8563 178 µM 1.06137303275179 0.119126425104856 no 450 0.144260203676242 183 23767530
SGTC_2728 chlorpromazine 9.18 µM 1.06104600836188 0.119195642828268 no 451 0.144334496428437 182 2726 A thorazine and dopamine antagonist.
SGTC_1254 0550-0035 264 µM 1.05987932764552 0.119442812828275 no 452 0.144599750715596 175 15121435
SGTC_1275 0867-0008 21.1 µM 1.05732985632971 0.11998419530294 no 453 0.145180535896321 160 3422836
SGTC_2350 9023895 38.85 µM 1.0570038954357 0.120053537895267 no 454 0.14525490480666 165 2997209
SGTC_175 3793-3120 23.7 µM 1.05694527253602 0.120066011908207 no 455 0.145268282507857 184 5322297
SGTC_3231 9132313 49.47 µM 1.05625423704702 0.120213122027712 no 456 0.145426038759318 178 4905967
SGTC_1235 benzylparaben 21.5 µM 1.05588121666078 0.120292584706753 no 457 0.145511243324858 167 7180
SGTC_2455 5377712 9.75 µM 1.05514352300171 0.120449840853664 no 458 0.145679844654223 158 2243908
SGTC_2635 hydroquinidine 100 µM 1.05430980910158 0.120627740108158 no 459 0.145870549628795 145 442912 An experimental heart treatment.
SGTC_1342 1486-1464 234 µM 1.05386130785664 0.120723518536803 no 460 0.145973209853166 175 3253938
SGTC_2816 7982706 58.44 µM 1.0533757366364 0.120827273679044 no 461 0.146084409971309 190 2981853
SGTC_2322 7413319 38.22 µM 1.05179205069081 0.12116610617763 no 462 0.146447483487433 187 1840400
SGTC_907 3448-6986 75.5 µM 1.05077010088447 0.121385108673227 no 463 0.14668209550897 182 590582
SGTC_2419 paclitaxel 166.5 µM 1.04862284727446 0.121846168643094 no 464 0.147175868093698 187 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2260 7964312 200 µM 1.04784586603513 0.1220133054046 no 465 0.147354813370177 169 231951
SGTC_2939 9044578 71.43 µM 1.04736311068532 0.122117232173809 no 466 0.147466069374266 166 2653634
SGTC_1596 piperlongumine 63 µM 1.04676381747068 0.122246333475371 no 467 0.147604261026307 156 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1957 st077035 62.4 µM 1.04165192354543 0.123351445870726 no 468 0.148786543055012 171 705593
SGTC_2987 9018338 71.43 µM 1.04113211011401 0.123464212304239 no 469 0.148907119356855 193 5055682
SGTC_1308 1187-1617 41.4 µM 1.03833008810159 0.124073316448373 no 470 0.149558202725805 173 2882570
SGTC_686 1319-0111 510 µM 1.03717624725522 0.124324748787019 no 471 0.149826862869731 179 4562600
SGTC_1631 benzylvanillin 81.9 µM 1.03517884287905 0.124760843163944 no 472 0.150292698725544 155 75506
SGTC_1884 5633444 25 µM 1.03411229246126 0.124994140989332 no 473 0.150541835130029 185 5724239
SGTC_1567 st069303 68.4 µM 1.0334636159338 0.125136181794085 no 474 0.150693494478377 185 5581319
SGTC_1500 4488-1866 171 µM 1.03152932007862 0.125560403945352 no 475 0.15114633301877 187 2900003
SGTC_3196 9111891 49.47 µM 1.03146028464084 0.125575563051239 no 476 0.151162511639569 184 18891510
SGTC_2283 7944793 200 µM 1.03135307465588 0.125599107224108 no 477 0.151187638841082 191 2970533
SGTC_1200 1643-0193 18.4 µM 1.02695451306758 0.126567723124978 no 478 0.152220941693267 191 5403974
SGTC_730 1436-0052 41.2 µM 1.02529585017431 0.126934328006169 no 479 0.152611806641536 155 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3285 9112818 20.8695 µM 1.02430769708887 0.127153084908566 no 480 0.152844981762118 208 17017947 YPR165W RHO1
SGTC_954 1189-0853 2.85 µM 1.02386790478322 0.127250530245137 no 481 0.152948835769529 174 2828194
SGTC_617 3770-0098 35 µM 1.01881761843577 0.128373252957506 no 482 0.154144779897196 176 5962639
SGTC_2701 st077767 14.721 µM 1.01877841831281 0.128381994299527 no 483 0.154154086895744 173 5721188
SGTC_936 3005-4620 401 µM 1.01861115515768 0.128419297408672 no 484 0.154193803140189 179 777207
SGTC_1919 st067113 52.3 µM 1.01786195103868 0.128586477600228 no 485 0.154371782946657 192 1268243
SGTC_965 1291-5240 308 µM 1.01733284293454 0.128704635710972 no 486 0.154497558878185 185 2834598
SGTC_2268 7933382 153.85 µM 1.01602352492069 0.128997350685198 no 487 0.154809092069238 174 935025 YOR257W CDC31
SGTC_1650 st011916 45.8 µM 1.01446216746664 0.129347015442169 no 488 0.155181136519194 190 242528
SGTC_2735 sertaconazole 140 nM 1.01307257034142 0.129658766586244 no 489 0.155512749469348 200 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_122 0236-0016 402.397 µM 1.01234497268864 0.129822207940551 no 490 0.155686569448327 195 6808838
SGTC_1539 benzyladenosine 56 µM 1.00814044993697 0.130769469969617 no 491 0.156693520601843 184 92208 A nucleotide analog.
SGTC_230 MPP+ 141.667 µM 1.00702690503414 0.131021145364057 no 492 0.156960922522068 178 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_728 3030-5151 22.5 µM 1.00652330069957 0.131135076213135 no 493 0.157081954443269 173 3125388
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.999853174351687 0.132650521808935 no 494 0.158690784048132 198 1377
SGTC_1688 st021091 57.6 µM 0.999596482661466 0.132709081968039 no 495 0.15875291301381 189 3656366
SGTC_1796 st049173 110.4 µM 0.995265887743723 0.133699723544181 no 496 0.159803481995949 185 94134
SGTC_2882 9058044 58.44 µM 0.993502231327628 0.134104620485456 no 497 0.160232631811581 200 18076804
SGTC_1395 3486-0190 4.35 µM 0.991704948732082 0.134518103079565 no 498 0.160670738146801 194 6748079
SGTC_914 3820-6779 408 µM 0.989082813014819 0.13512291967642 no 499 0.16131131292589 178 2893481
SGTC_2005 4024620 188 µM 0.988900428018109 0.135165057487158 no 500 0.161355930555935 184 236743
SGTC_1757 st041620 31.8375 µM 0.988712934427467 0.135208384966761 no 501 0.161401806312675 169 5289815
SGTC_1933 st074711 15.9 µM 0.988625442119554 0.135228606628975 no 502 0.161423216759339 211 17250958
SGTC_2992 9074591 71.4286 µM 0.987446910607854 0.135501196832312 no 503 0.161711798444503 185 17741321
SGTC_3121 9125696 49.47 µM 0.984618630708956 0.136156903260985 no 504 0.162405717376788 189 1235365
SGTC_3070 9117005 49.47 µM 0.984116150736077 0.136273624664497 no 505 0.162529203362138 157 8779016
SGTC_741 4582-0002 126 µM 0.98368553229661 0.136373707768877 no 506 0.162635077757312 196 2912688
SGTC_1977 st070720 65.3 µM 0.981717152806488 0.13683183308203 no 507 0.163119606321838 159 682188
SGTC_409 arachidonic acid 100 µM 0.980843593105398 0.137035484082531 no 508 0.163334938608557 185 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_550 4123-0385 25.7 µM 0.977478101105814 0.137822008944448 no 509 0.164166257036025 180 5731123
SGTC_1743 st037606 46.3785 µM 0.975562690270468 0.138271018478816 no 510 0.164640610539729 152 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1760 st045453 10.4495 µM 0.973420371595971 0.138774399842512 no 511 0.165172209089851 208 3323419 YIL048W NEO1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.97210234973716 0.139084715303727 no 512 0.165499816650384 166 688664
SGTC_3172 9105863 49.47 µM 0.971052462582043 0.139332238769498 no 513 0.165761077178689 186 2348785
SGTC_1851 st056236 18.9 µM 0.970113960871001 0.139553755335377 no 514 0.165994845432997 187 5393171
SGTC_1563 conessine 56.1 µM 0.969464823910503 0.139707112570478 no 515 0.166156661363945 157 441082 An anti-amoebic, histamine inhibitor.
SGTC_1326 1431-2094 10.8 µM 0.968844576281406 0.139853751767921 no 516 0.166311370969868 195 616278
SGTC_2931 9014674 55.67 µM 0.9670947175975 0.140268017829255 no 517 0.166748342983783 187 2996810
SGTC_1150 3909-7983 10.9 µM 0.965661556389447 0.140607928333094 no 518 0.167106781100432 207 23965914
SGTC_2118 5526350 200 µM 0.965318278060461 0.140689428415187 no 519 0.167192709780377 198 743594
SGTC_2680 butyl paraben 22.24 µM 0.964413830829938 0.140904312969252 no 520 0.167419245395793 222 7184 An antifungal and steroid mimetic.
SGTC_1388 3346-4487 254 µM 0.963541122067183 0.141111867847616 no 521 0.167638018922932 208 3345614
SGTC_1441 4106-0040 13 µM 0.960217499534818 0.141904217061326 no 522 0.168472880653807 178 2904180
SGTC_1887 st057648 70.8 µM 0.958770127667944 0.142250209258413 no 523 0.168837280577482 212 688672
SGTC_1494 4358-1428 177 µM 0.958213686301747 0.142383377565666 no 524 0.168977508610008 175 1564571
SGTC_2947 9072639 7.68 µM 0.956258198865939 0.14285203629281 no 525 0.16947090155128 199 16488146
SGTC_1295 1013-0063 9.78 µM 0.955566462905191 0.14301806943466 no 526 0.169645655957654 186 6826038
SGTC_898 1000-0849 28.3 µM 0.953690414976415 0.143469021856325 no 527 0.170120186699204 222 6751807
SGTC_1068 loratadine 26.9 µM 0.951575284295691 0.143978593530314 no 528 0.17065621054773 187 3957 A H1 histamine antagonist.
SGTC_870 0573-2213 57.6 µM 0.95143331190137 0.144012840806602 no 529 0.1706922283702 185 3916321
SGTC_1312 1218-2183 165 µM 0.947270454784751 0.145019468065217 no 530 0.171750491007148 202 6744073
SGTC_260 nsc-65238 3.989 µM 0.946538994336984 0.1451968317485 no 531 0.171936871516785 182 3246252
SGTC_2855 9016525 58.44 µM 0.944920881172735 0.145589708380957 no 532 0.172349635076211 201 43811474
SGTC_1928 4'-methoxychalcone 40.3 µM 0.944860582627449 0.145604362623128 no 533 0.172365028804893 210 641818
SGTC_200 k038-0079 37.545 µM 0.944575460476441 0.145673668755782 no 534 0.172437830051937 214 3436683
SGTC_3161 9100388 49.47 µM 0.943992157201645 0.145815524422013 no 535 0.172586828033224 210 25236368
SGTC_184 1494-0393 24.714 µM 0.943668185405389 0.145894352403852 no 536 0.172669618277657 219 3090647
SGTC_2515 chrysin 20.77 µM 0.94270008567601 0.146130078554214 no 537 0.172917164770417 177 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_73 0327-0325 16.231 µM 0.938387040997318 0.147183385220196 no 538 0.174022771606092 161 53298
SGTC_2286 7945697 125 µM 0.938021603496934 0.147272863542046 no 539 0.174116654017618 191 1245733
SGTC_1993 st073995 70.8 µM 0.937246807963336 0.147462694819017 no 540 0.174315808671648 206 3098394
SGTC_261 5-fluorouridine 15.376 µM 0.930173140198951 0.149203380826819 no 541 0.176140723224601 187 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2607 solasodine 47.35 µM 0.923047227901272 0.150970742948987 no 542 0.177991296946172 218 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2152 5568786 200 µM 0.921985372146032 0.151235291351933 no 543 0.178268102881668 214 5399883
SGTC_1406 3909-7906 11.9 µM 0.920495026348513 0.151607112646691 no 544 0.178657065464664 195 X1406
SGTC_2800 7887935 81.82 µM 0.919677331541916 0.151811374480012 no 545 0.17887070097584 202 2961002
SGTC_2906 7926292 26.41 µM 0.918077660986679 0.152211504014094 no 546 0.179289104571973 189 2966319
SGTC_1801 st050089 28.441 µM 0.918010431110176 0.152228335707084 no 547 0.179306702422599 204 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_772 k072-0172 35.3 µM 0.916998052262602 0.152481944601642 no 548 0.17957183038287 165 5861980
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.916887693999555 0.15250960715571 no 549 0.179600746564623 206 5106787 A p450 inhibitor.
SGTC_2897 9048598 12.99 µM 0.915587152204918 0.152835853601796 no 550 0.179941736229815 187 6467404
SGTC_843 0310-0051 143 µM 0.91381027170198 0.153282339230365 no 551 0.180408274082028 208 2065037
SGTC_3110 9122132 49.47 µM 0.911910119054102 0.153760755364407 no 552 0.180908017137101 176 918317
SGTC_126 0417-1624 672.48 µM 0.910591811326275 0.154093256065235 no 553 0.181255243344627 248 41912 YDL195W SEC31
SGTC_3170 9103054 49.47 µM 0.909101762307684 0.154469645205535 no 554 0.181648206226759 211 16432970
SGTC_1941 st076221 61.8 µM 0.908901484737935 0.154520281985415 no 555 0.181701065002254 194 2828568
SGTC_668 1682-0499 62.6 µM 0.906447456033552 0.155141632245372 no 556 0.182349532103989 201 682214
SGTC_2664 lyso-paf C-16 73.48 µM 0.905625319211394 0.155350162369084 no 557 0.182567101383309 229 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_901 1112-0062 60.1 µM 0.902959619112629 0.156027573008575 no 558 0.183273663401995 204 1908457
SGTC_3206 9114350 49.47 µM 0.90188160330799 0.156302071571879 no 559 0.183559882441612 195 17087243
SGTC_2656 pseudo-anisatin 100 µM 0.900054482405652 0.156768043174746 no 560 0.184045628737661 230 6708809 A neurotoxin.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.898809683790077 0.157086027878176 no 561 0.184377020570301 223 65057 A dermal irritant. YDR527W RBA50
SGTC_931 2812-0076 566 µM 0.898708882084569 0.157111796300305 no 562 0.18440387236385 204 3450959
SGTC_291 SEC14.278 35.5 µM 0.896727396308995 0.157618897387173 no 563 0.184932199009935 199 1068044
SGTC_2571 chrysanthemic acid 100 µM 0.896387367586153 0.157706025389535 no 564 0.185022955863282 217 2743 An insecticide.
SGTC_1472 k841-0093 193 µM 0.896292477359613 0.157730345439331 no 565 0.185048287891987 209 X1472
SGTC_484 loperamide 105 µM 0.895674563764371 0.157888774891496 no 566 0.185213299671651 165 3955 An opioid-receptor agonist.
SGTC_2875 9039966 71.43 µM 0.894771014369184 0.158120627754066 no 567 0.185454753995132 204 6463691
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.894353052560271 0.158227953277021 no 568 0.185566511446659 234 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_414 piperonyl butoxide 100 µM 0.894256579742948 0.158252732653694 no 569 0.185592312935505 204 5794 A potent inhibitor of cytochrome P450.
SGTC_532 1548-0774 215 µM 0.894138091959915 0.15828317013461 no 570 0.185624005334965 216 5932993
SGTC_2279 7948423 32.93 µM 0.893906637306842 0.158342637948295 no 571 0.185685923119143 200 1247112
SGTC_1684 st024538 14.6195 µM 0.893004819807562 0.158574482384349 no 572 0.18592729578274 203 6732859
SGTC_1780 st038448 24.544 µM 0.892716810376725 0.158648572384454 no 573 0.186004422864516 205 728868 YDL195W SEC31
SGTC_2320 7373003 200 µM 0.884782580478107 0.160698565298451 no 574 0.18813695315209 215 5415828
SGTC_1501 4491-0275 38.4 µM 0.881714454942819 0.161495904419234 no 575 0.188965621065416 215 5104718
SGTC_2727 riluzole 51.77 µM 0.880276851438931 0.161870392286284 no 576 0.189354674831349 232 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1480 1070-0044 41.2 µM 0.880043468289524 0.161931240661566 no 577 0.189417881008355 209 3124987
SGTC_630 4356-0227 183 µM 0.878692451167402 0.162283774777097 no 578 0.189784026384383 234 779312
SGTC_1737 st035557 69.7 µM 0.877993528571008 0.162466347438649 no 579 0.189973615325286 215 5716916
SGTC_1131 3454-3128 32.3 µM 0.877921818364877 0.162485087146839 no 580 0.189993073936557 198 710982
SGTC_3000 9075062 71.4286 µM 0.87770224717989 0.162542475451671 no 581 0.190052662339224 206 17057871
SGTC_2922 7999257 32.47 µM 0.877139067876192 0.16268973130839 no 582 0.190205553456323 237 2988377
SGTC_9 0092-0002 10.449 µM 0.876552852368351 0.162843102643297 no 583 0.190364778652349 224 759368
SGTC_1767 st044992 70.3 µM 0.87448514799942 0.163384825760336 no 584 0.190927052461257 234 9600693
SGTC_3158 9100007 49.47 µM 0.868629964148083 0.164925183395583 no 585 0.192524779844282 219 19297233
SGTC_2403 6032726 181.2 µM 0.86750178857571 0.16522305628417 no 586 0.192833566109761 207 2881040
SGTC_651 3253-0966 34.4 µM 0.865803470403902 0.16567212044509 no 587 0.193298972870008 220 781462
SGTC_2072 5231554 129 µM 0.865590294541145 0.165728543460263 no 588 0.193357439922596 246 789545
SGTC_2883 9059145 45.46 µM 0.865524641899144 0.165745922788978 no 589 0.193375448432975 251 16476510
SGTC_1817 st052116 64.4 µM 0.864030971745008 0.166141640055053 no 590 0.193785438395078 193 4361398
SGTC_3217 9129673 49.47 µM 0.862522178926435 0.166541982873034 no 591 0.194200116833225 222 17248312
SGTC_3052 9092717 49.47 µM 0.859285207036596 0.167402979576821 no 592 0.195091591784265 231 25237534
SGTC_1329 1447-1697 50.6 µM 0.859115540005177 0.167448187996715 no 593 0.195138387268299 208 2840515
SGTC_3197 9113331 49.47 µM 0.859066928837256 0.167461142075225 no 594 0.195151795862898 201 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_878 0828-0289 13.7 µM 0.85836203421803 0.16764905748582 no 595 0.19534629242675 223 745350 YLR208W SEC13
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.858062069767359 0.167729065145707 no 596 0.195429095193243 252 5393153
SGTC_1113 artemisinin 1.17947 µM 0.856911780752184 0.16803610249403 no 597 0.195746820770633 243 2240 An anti-malaria and mitochondrial poison.
SGTC_1443 4112-3303 14 µM 0.850626942197441 0.16972004556736 no 598 0.197488309107594 245 704433
SGTC_168 3970-0862 530.542 µM 0.850359972353099 0.169791815595713 no 599 0.197562491558761 253 3135186
SGTC_2889 9059656 51.95 µM 0.848438873864299 0.170308842084481 no 600 0.198096800474173 229 3949838
SGTC_1052 3253-3998 198 µM 0.848167687311564 0.170381907847024 no 601 0.198172294929074 222 5450317
SGTC_374 0880-0231 82.3 µM 0.847871388448175 0.170461762565678 no 602 0.198254800145109 233 6833587
SGTC_3036 9090181 49.47 µM 0.846897478520668 0.170724407270604 no 603 0.198526134024294 230 25236586
SGTC_682 0kpi-0099 17 µM 0.845508718939305 0.171099376679139 no 604 0.198913433348653 253 1714895 YML126C ERG13
SGTC_2643 anethole 100 µM 0.844730259468605 0.171309793359109 no 605 0.199130730312116 242 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_191 3914-0123 66.505 µM 0.844420833534442 0.171393476752408 no 606 0.199217142289577 236 3144412
SGTC_286 k060-0067 22.9 µM 0.844100741002244 0.171480072388744 no 607 0.199306556841688 222 5985051
SGTC_465 cgp-37157 41 µM 0.842584089688293 0.171890756842177 no 608 0.199730546186567 198 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1643 st009866 20.2 µM 0.841831215312983 0.172094856019743 no 609 0.199941218303485 210 3156273 YOR207C RET1
SGTC_342 k048-0088 23.3 µM 0.840775469006283 0.172381322162106 no 610 0.200236866136299 239 6820570
SGTC_1005 4092-0690 4.4 µM 0.840220821394906 0.1725319420221 no 611 0.200392293090698 233 1529343
SGTC_1046 2001-0062 216 µM 0.839992606643963 0.172593940281685 no 612 0.200456265948492 231 739778
SGTC_1557 sumaresinolic acid 42.3 µM 0.838826397173818 0.172910981841781 no 613 0.200783367701371 206 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3091 9116372 49.47 µM 0.838427861090951 0.173019411468375 no 614 0.200895223639297 220 17169793
SGTC_2864 9034755 47.6 µM 0.836515477063927 0.173540315838889 no 615 0.201432486754755 221 4930451
SGTC_417 st075190 100 µM 0.835426564855193 0.173837364446428 no 616 0.201738788950142 240 222757
SGTC_3083 9117465 49.47 µM 0.834781374252578 0.174013520981152 no 617 0.201920407375571 236 16420915
SGTC_2214 7179297 48.276 µM 0.834631973423541 0.174054328099827 no 618 0.201962477029548 225 769744
SGTC_1127 asiatic acid 681.4 nM 0.833940741715451 0.174243209270112 no 619 0.202157188668198 234 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2954 9074818 52.69 µM 0.833655506911895 0.174321188498729 no 620 0.20223756859858 235 16648742
SGTC_2115 tiliquinol 12.7705 µM 0.830474598943629 0.175192306466609 no 621 0.203135251752323 232 71208 A bioactive hydroxyquinoline.
SGTC_3267 9137951 49.47 µM 0.828179760358138 0.17582247835095 no 622 0.203784352149374 236 16643986
SGTC_389 tpck 16.7 µM 0.828069200837881 0.175852874647124 no 623 0.20381565535191 209 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1934 st074720 32.6 µM 0.827093296189556 0.176121325924207 no 624 0.20409209180766 228 17250992
SGTC_2047 4141938 200 µM 0.826189636877822 0.176370135186264 no 625 0.204348262969175 250 3807862
SGTC_2224 6650123 117.647 µM 0.824504114863301 0.176834812724342 no 626 0.204826589343999 228 2908370
SGTC_2526 patulin 37.61 µM 0.822704345270436 0.177331840361356 no 627 0.205338071853977 243 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1719 st032227 49.2 µM 0.822357573063476 0.177427706859079 no 628 0.205436709300932 235 3125804
SGTC_1017 4239-0030 168 µM 0.822307566440908 0.177441534079132 no 629 0.205450935730717 231 1149593
SGTC_1337 1486-1011 40.3 µM 0.82024674061013 0.17801196003717 no 630 0.206037730655888 238 X1337
SGTC_569 4130-2812 160 µM 0.819531690896211 0.17821015200212 no 631 0.206241564335847 231 743552
SGTC_2836 9010338 19.48 µM 0.818387761179335 0.178527506708209 no 632 0.206567903971487 231 2994051
SGTC_542 3381-0244 89.3 µM 0.818256623106311 0.178563910417115 no 633 0.206605334499264 238 1112843
SGTC_2936 9038235 15.59 µM 0.817851893403055 0.178676292180616 no 634 0.206720881170087 232 4749415
SGTC_3281 9140613 49.47 µM 0.81622395635795 0.179128773028739 no 635 0.207186028791435 213 16013766
SGTC_134 0269-0018 6.916 µM 0.8151024673999 0.179440906907933 no 636 0.207506829703751 231 4378915
SGTC_1999 st074831 12.5 µM 0.8147255079211 0.179545899363735 no 637 0.207614724512513 238 17112523
SGTC_2753 fluvastatin 17.09 µM 0.812964199494049 0.180036978452136 no 638 0.208119292168831 236 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_949 1165-0505 146 µM 0.808901504884705 0.181172930746736 no 639 0.209285901619443 241 6244267
SGTC_677 0929-0063 136 µM 0.804613752743971 0.182376668244666 no 640 0.210521301716216 266 1539583
SGTC_1265 0819-1001 68.8 µM 0.802928091902663 0.182851263516835 no 641 0.211008149022125 249 3106768
SGTC_1992 st073643 23.3 µM 0.802344431518684 0.18301577172068 no 642 0.211176873699219 237 3161292
SGTC_3033 9090887 49.47 µM 0.8011005016203 0.183366688893414 no 643 0.211536732921946 232 19325384
SGTC_3276 9139060 49.47 µM 0.800084818026813 0.183653527838456 no 644 0.211830828351145 264 4870619
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.799868022315387 0.183714789248181 no 645 0.211893633422094 224 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_516 3992-2719 87.3 µM 0.799821115868702 0.183728045590682 no 646 0.211907223513055 212 5350887 YDR037W KRS1
SGTC_698 k064-0052 127 µM 0.799553991162568 0.183803549699066 no 647 0.211984626625142 266 5088751
SGTC_1285 0929-0069 65.5 µM 0.799459412672273 0.183830287405665 no 648 0.212012036026186 224 1206237
SGTC_2143 5623677 140.463 µM 0.797919111716222 0.184266077421776 no 649 0.212458715941304 229 5375313
SGTC_2228 7354201 200 µM 0.797915450884805 0.184267113928563 no 650 0.212459778219409 262 753451
SGTC_151 3013-0144 2.285 µM 0.797909995890591 0.184268658431034 no 651 0.212461361122671 256 906558 YHR107C CDC12
SGTC_2161 5662504 8.5105 µM 0.797902113801268 0.184270890144502 no 652 0.212463648320567 221 2859334
SGTC_2162 5663267 200 µM 0.797841507750937 0.184288050539653 no 653 0.212481235258824 238 6456493
SGTC_860 0443-0016 25.1 µM 0.797833766617363 0.184290242486675 no 654 0.212483481677285 260 5337942
SGTC_2436 5633522 8.09 µM 0.793887465093927 0.18540977223244 no 655 0.213630473817993 244 5724242
SGTC_2407 paclitaxel 400 µM 0.791632679183502 0.186051325569563 no 656 0.214287443209801 249 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2913 7966556 36.57 µM 0.791626187630686 0.186053174592951 no 657 0.214289336326753 231 2976516
SGTC_1660 st012960 28.1 µM 0.790269399292579 0.186439885787019 no 658 0.214685226923381 233 24207266
SGTC_1951 sophoraflavanone G 9.2 µM 0.790095328864857 0.186489535270537 no 659 0.214736048822993 228 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_76 0433-0009 400.328 µM 0.787933270179679 0.187106893833909 no 660 0.215367869586965 229 2841569
SGTC_2300 7976697 71.57 µM 0.787272660753224 0.187295777409692 no 661 0.21556113511314 223 2236109
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.786953592501349 0.187387048637897 no 662 0.215654516586147 250 6708784 An antioxidant flavonoid
SGTC_1301 naphtanilide LB 4.81 µM 0.785371745593784 0.18783995056081 no 663 0.21611782081871 252 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3342 9147791 14.508 µM 0.785290785134799 0.187863148690287 no 664 0.216141548675344 233 1838168
SGTC_2233 sulbentine 40.3845 µM 0.783369043145556 0.188414317275788 no 665 0.216705214767066 249 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1702 st027038 51 µM 0.782127651362956 0.188770886494246 no 666 0.217069778865437 236 5521182
SGTC_2195 6536160 144.242 µM 0.775272214263436 0.190747477841373 no 667 0.219089412201018 234 3834386
SGTC_2610 ononetin 44.17 µM 0.774187351048199 0.191061430560972 no 668 0.219410003634081 242 259632
SGTC_981 1488-1094 54.9 µM 0.773805506671879 0.191172009322236 no 669 0.219522907799155 249 3449522
SGTC_2557 derrustone 83.84 µM 0.773690377475104 0.191205357418765 no 670 0.219556955873445 274 629853 An antioxidant.
SGTC_2869 9037858 32.47 µM 0.772399082668216 0.191579635608852 no 671 0.219939048509405 247 27187042
SGTC_3005 9076496 71.4286 µM 0.772324239466551 0.191601342452417 no 672 0.219961206218571 246 21368410
SGTC_2655 perillic acid 100 µM 0.772293925843722 0.191610134769356 no 673 0.219970181084689 253 5702197 An apoptosis inducer.
SGTC_315 k915-0449 187 µM 0.770732534979296 0.192063342633448 no 674 0.220432741592508 243 20970215 YNL149C PGA2
SGTC_128 0906-2981 13.371 µM 0.770655482667449 0.1920857247366 no 675 0.220455582689313 265 6740226
SGTC_1037 k284-1091 78.7 µM 0.767168238612403 0.193100367012628 no 676 0.22149074712605 240 3334711
SGTC_1163 k060-0048 49.9 µM 0.76711109211401 0.193117021459271 no 677 0.221507733779619 242 6809982
SGTC_1059 3448-6867 171 µM 0.765535154236867 0.193576649205484 no 678 0.221976470717532 268 3934407
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.764265098749779 0.193947550359367 no 679 0.22235463972533 282 6728940
SGTC_2377 9073351 62.6 µM 0.763191984433102 0.194261275022772 no 680 0.222674454206216 254 7337946 YHR072W ERG7
SGTC_2665 lovastatin 100 µM 0.761666985433916 0.19470763931964 no 681 0.223129392184977 254 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1207 2099-0101 141 µM 0.761335048776618 0.194804879170451 no 682 0.22322848567268 255 5837381
SGTC_950 1165-0508 94.1 µM 0.759219831079401 0.195425219436071 no 683 0.223860532516651 253 6148369
SGTC_1891 st059073 26.2 µM 0.758309139622933 0.195692671483573 no 684 0.224132968546383 254 688754
SGTC_2654 protoveratrine a 100 µM 0.757457233950713 0.195943060347411 no 685 0.224387989011899 272 5702278 A heart drug and vasodilator.
SGTC_2481 5478948 45.16 µM 0.757236885513485 0.196007855945139 no 686 0.224453977762398 238 77792
SGTC_2035 5154463 94.595 µM 0.75591202134508 0.196397719075674 no 687 0.224850972967382 271 2769623
SGTC_3312 9133330 71.43 µM 0.755542696864265 0.196506482609044 no 688 0.224961711864611 258 17617324
SGTC_55 0767-0285 6.563 µM 0.753352422998402 0.197152253019717 no 689 0.225619082300029 276 3116166
SGTC_1385 3091-4834 14.1 µM 0.75314784630326 0.197212634984062 no 690 0.22568053768881 232 4072814
SGTC_2389 9091542 195.52 µM 0.751383005432977 0.197734002163973 no 691 0.226211093725169 252 3626624 YOL127W RPL25
SGTC_2499 avocadenofuran 51.48 µM 0.749162409800414 0.198391189912589 no 692 0.226879661350296 250 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_505 gw-5074 63.9 µM 0.747021681694732 0.199025986886478 no 693 0.227525236622836 261 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_726 3448-4391 34.2 µM 0.743708053653254 0.200010997692667 no 694 0.228526558039789 258 1356692
SGTC_830 4076-0286 57.8 µM 0.738056440063876 0.201697746517442 no 695 0.230240076284701 259 6866659
SGTC_429 1112-0049 25.5 µM 0.737222083500096 0.201947483643033 no 696 0.23049365301448 250 2836170
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.736785239193987 0.202078312374963 no 697 0.230626480491038 246 688667
SGTC_1976 st070609 63.5 µM 0.736650046483933 0.202118810966965 no 698 0.230667596035726 245 682556
SGTC_1247 0448-0043 5.84 µM 0.734475635672984 0.202770848705308 no 699 0.231329452059212 257 3089013 YGL099W LSG1
SGTC_1092 toremifene 6.32 µM 0.733221176996547 0.203147592610179 no 700 0.231711770593218 270 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3026 9090633 49.47 µM 0.733186569618412 0.203157991951994 no 701 0.23172232279362 264 25236842
SGTC_471 1-acyl-paf 4 µM 0.729746947599201 0.204193165613926 no 702 0.232772439193788 244 16759367
SGTC_1859 st055998 20 µM 0.72844209902458 0.204586687582004 no 703 0.233171500198754 266 676301
SGTC_2734 clemastine 41.6 µM 0.726570603113743 0.205151888619844 no 704 0.233744520986618 291 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2423 st077119 87.2 µM 0.725291913241427 0.205538592306194 no 705 0.234136482883901 249 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2337 9009472 200 µM 0.723403190931216 0.206110574142739 no 706 0.234716105692012 262 5742383
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.722964964211331 0.206243421764896 no 707 0.234850704728617 273 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1193 1488-0126 41.5 µM 0.722661041698746 0.206335585113193 no 708 0.234944077980558 252 1384710
SGTC_2133 5320837 200 µM 0.722571447309687 0.206362758928949 no 709 0.234971607725218 251 2841355
SGTC_98 0074-0023 107.663 µM 0.721882633016269 0.206571745872405 no 710 0.235183319799769 259 3563821
SGTC_903 1134-0042 114 µM 0.721468750736363 0.206697378436941 no 711 0.235310580169941 273 701009
SGTC_1833 st055984 71 µM 0.719657142787972 0.207247818080586 no 712 0.235868059830907 253 676288
SGTC_1766 st045414 44.774 µM 0.717239694656281 0.207983685030655 no 713 0.236613105155975 272 253960
SGTC_2091 4-phenylthiadiazole 200 µM 0.715184785398518 0.208610406973304 no 714 0.237247434547092 258 270010
SGTC_3336 9143619 71.43 µM 0.7140322977721 0.208962388218131 no 715 0.237603604066055 258 45595730
SGTC_3130 9127414 49.47 µM 0.712960457813628 0.209290052599348 no 716 0.237935113060144 272 1494646
SGTC_581 0958-0271 211 µM 0.711189982535041 0.209831953515148 no 717 0.238483257676898 257 4591145
SGTC_872 0588-0139 234 µM 0.70868558638577 0.210599897240339 no 718 0.239259805659846 249 2047100
SGTC_1204 4049-0315 18.3 µM 0.708240173210157 0.210736650500716 no 719 0.239398061235879 266 588402
SGTC_2482 5981709 142.65 µM 0.70819793152438 0.210749622484578 no 720 0.239411175256074 278 877755
SGTC_2872 9044037 25.97 µM 0.706647147079616 0.21122617646187 no 721 0.239892891033854 261 6465195
SGTC_2095 5432005 200 µM 0.705167716639022 0.211681391382474 no 722 0.24035293461431 283 783734
SGTC_650 1328-0195 38 µM 0.702020210138151 0.212651774808816 no 723 0.241333279914781 283 2780821
SGTC_509 pifithrin 175 µM 0.699703981769259 0.213367529523383 no 724 0.242056094655915 281 4817 A p53 inhibitor.
SGTC_1729 st035615 45.989 µM 0.699276189958873 0.213499878088684 no 725 0.242189722001903 276 17385451
SGTC_3006 9075424 71.4286 µM 0.698358832157991 0.213783847918274 no 726 0.242476407581711 267 7465181
SGTC_206 4546-0025 72.014 µM 0.697648036298822 0.214004027281077 no 727 0.242698666350798 289 6620745 YIL048W NEO1
SGTC_2131 toluylene red 5.2905 µM 0.697238066657568 0.214131081343621 no 728 0.242826909898107 246 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1157 4092-0394 27.6 µM 0.696803873461929 0.214265690399141 no 729 0.242962770847627 273 3659885
SGTC_1562 morin hydrate 59.1 µM 0.695724153593165 0.214600639672614 no 730 0.243300798113063 269 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1411 3909-8223 150 µM 0.695644455653671 0.214625375518133 no 731 0.24332575916963 273 X1411
SGTC_2686 alizarin 95.37 µM 0.695529814338312 0.214660959643644 no 732 0.24336166677036 252 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1126 isoteolin 1.0172 µM 0.695095072437667 0.214795932637959 no 733 0.243497861308195 264 133323
SGTC_472 calcifediol 10 µM 0.694226995945098 0.215065589175903 no 734 0.243769932647889 269 5283731 A vitamin D metabolite.
SGTC_2961 9083290 32.55 µM 0.693960699904384 0.2151483499161 no 735 0.243853427665049 275 17741490
SGTC_1334 1486-0610 236 µM 0.692245508881215 0.215681847915861 no 736 0.244391581890567 252 3742339
SGTC_433 pimozide 108 µM 0.691627637894969 0.215874220050186 no 737 0.244585600295093 272 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.689621880065403 0.216499391134668 no 738 0.245216002060155 254 6857784
SGTC_3263 9137018 49.47 µM 0.689199707399596 0.216631110709309 no 739 0.245348800465984 275 43844957
SGTC_1852 st056254 31.4 µM 0.687779491382832 0.217074563962441 no 740 0.24579582644962 270 442583
SGTC_877 0771-0151 33.1 µM 0.687482591956737 0.217167335130147 no 741 0.245889333486004 263 6166523
SGTC_1025 k007-0731 70 µM 0.687472904712988 0.217170362456507 no 742 0.245892384758093 281 6256118
SGTC_3098 9119039 49.47 µM 0.68509178644806 0.217915216468562 no 743 0.246643001452915 275 17161528
SGTC_3023 9089636 49.47 µM 0.682314313983417 0.21878591536816 no 744 0.24752011194482 285 17249241
SGTC_254 nsc-64875 3.808 µM 0.681578203489045 0.219017010895982 no 745 0.24775285063911 269 56993
SGTC_2821 7996764 71.43 µM 0.681515499555767 0.219036702740321 no 746 0.247772681365816 232 2987135
SGTC_953 1188-0045 9.7 µM 0.680047956536753 0.219497867692133 no 747 0.248237048001717 277 6144426
SGTC_78 0336-0123 156.75 µM 0.679782223724027 0.219581431938884 no 748 0.248321181982783 271 6765896
SGTC_2334 9017922 200 µM 0.679277983275698 0.219740049227824 no 749 0.248480871931487 285 3163164
SGTC_812 4251-0442 148 µM 0.67879829115283 0.219891005466008 no 750 0.248632838348108 285 5723007
SGTC_413 propylparaben 100 µM 0.67865894631381 0.219934867605019 no 751 0.248676992056313 270 7175 A pharmaceutical preservative.
SGTC_51 1013-0126 23.419 µM 0.678440977987361 0.220003488445531 no 752 0.248746067286337 272 1627850
SGTC_31 0508-1974 57.237 µM 0.676063336926481 0.220752815361149 no 753 0.24950021648237 253 6810525
SGTC_1347 1493-0251 600 nM 0.675690074555474 0.220870583687974 no 754 0.249618719494948 265 3986378
SGTC_2256 7954252 200 µM 0.674982010828359 0.221094084282186 no 755 0.249843597075982 286 2972920
SGTC_3304 9125678 46.087 µM 0.674166386840995 0.221351696637012 no 756 0.250102768503689 280 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.673943605569814 0.221422091257561 no 757 0.250173583928399 286 2374 Ca(2+)-ATPase inhibitor.
SGTC_2443 5493264 126.67 µM 0.673829387597847 0.221458186914918 no 758 0.250209894488794 286 5340055
SGTC_1980 st071811 45.7 µM 0.673382485945657 0.221599451034839 no 759 0.250351993991595 291 4974850
SGTC_71 0417-1750 47.813 µM 0.67309371886283 0.221690756727383 no 760 0.250443834834915 254 6811472
SGTC_2104 5389443 200 µM 0.671622077580065 0.222156410953875 no 761 0.250912159798465 276 2244536
SGTC_1570 verbenone 133 µM 0.669321020646276 0.222885625081694 no 762 0.251645360247985 284 29025 A natural terpanoid with antifungal properties.
SGTC_1171 0368-0077 21.4 µM 0.668731842642017 0.223072556984628 no 763 0.251833275604106 292 3239779
SGTC_1784 st039334 36.3 µM 0.667983872949174 0.223309998201342 no 764 0.252071943445524 308 3496984
SGTC_1339 1486-1321 22.7 µM 0.667084533622572 0.223595681699488 no 765 0.252359069376679 282 3469382
SGTC_2019 4016004 108 µM 0.666590945612534 0.223752562819515 no 766 0.252516727097166 289 45595336
SGTC_1196 1588-0294 184 µM 0.66646689053715 0.223792002097811 no 767 0.252556359882589 294 6144269
SGTC_1831 st055328 12 µM 0.666305753528312 0.223843236270681 no 768 0.252607844397997 277 1103068
SGTC_2704 st078022 71.1 µM 0.665280385543974 0.224169412364274 no 769 0.252935586843544 289 54697681
SGTC_227 fluconazole 33.516 µM 0.664943168724461 0.224276742136747 no 770 0.25304342167638 294 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1713 st033146 12.748 µM 0.66489356697915 0.22429253190053 no 771 0.253059285309584 298 674619
SGTC_3074 9116018 49.47 µM 0.664086059273437 0.224549675236128 no 772 0.253317616047401 327 17027303
SGTC_2838 9002687 71.43 µM 0.661548944650193 0.225358683254511 no 773 0.254130168553632 281 6457060
SGTC_2621 lithochol-11-enic acid 100 µM 0.66123615746631 0.225458535638826 no 774 0.254230438342991 295 6708711
SGTC_3079 9117512 49.47 µM 0.659733819740075 0.225938482188359 no 775 0.254712329783616 332 7185044
SGTC_1161 k007-0610 110 µM 0.657347607303947 0.226701983200709 no 776 0.255478715837723 292 5843850
SGTC_778 3456-2434 196 µM 0.650935383597908 0.228760857553865 no 777 0.257544099622704 257 5539063
SGTC_1964 st076914 61 µM 0.650787324149675 0.228808521014414 no 778 0.257591891948846 311 24208661
SGTC_2768 sulfasalazine 50.2 µM 0.65073128790249 0.228826561718851 no 779 0.257609981172488 299 5384001 An antioxidant and salicylic acid derivative.
SGTC_2409 alverine citrate 63.97 µM 0.650532401406546 0.228890599084871 no 780 0.257674189624741 257 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.648437761444974 0.229565640554141 no 781 0.258350926738625 277 4174840
SGTC_1820 st053765 18.6 µM 0.648182471910156 0.229647989123507 no 782 0.258433468700534 281 3690829
SGTC_157 1348-1695 65.819 µM 0.647912403390719 0.229735122947898 no 783 0.258520803973711 278 5380510
SGTC_1666 st014829 29 µM 0.647903240908264 0.229738079419193 no 784 0.258523767222844 286 3858230
SGTC_1221 2958-7315 257 µM 0.647083931430625 0.230002533299439 no 785 0.258788812154104 283 4562705
SGTC_2057 5236571 38.335 µM 0.646858062006233 0.230075468596921 no 786 0.258861905168097 290 54684039 YBR257W POP4
SGTC_272 doxorubicin 8.13 µM 0.646676431878209 0.230134128008157 no 787 0.258920689766329 298 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3030 9087619 49.47 µM 0.64657452361898 0.230167044044857 no 788 0.258953675402579 278 25236973
SGTC_3192 9110362 49.47 µM 0.646288028672243 0.230259595090088 no 789 0.259046419648919 309 16649480
SGTC_770 0389-1121 67.2 µM 0.643474466968289 0.231169609998654 no 790 0.259958138652282 292 6753108
SGTC_612 0302-0167 22.4 µM 0.643295546995492 0.231227547438704 no 791 0.260016172589213 315 235821
SGTC_1287 0971-0001 34.6 µM 0.643239441102785 0.231245717183764 no 792 0.260034372301374 288 4665869
SGTC_733 4069-0007 56.1 µM 0.640648418401481 0.232085680257685 no 793 0.260875567082724 290 5717425 YNL287W SEC21
SGTC_1187 1391-0724 117 µM 0.639572516560357 0.232434966752655 no 794 0.26122527743393 288 6997986
SGTC_1645 Cervolide 78 µM 0.639189191599667 0.232559482008148 no 795 0.261349931273919 307 23173 A fragrance.
SGTC_1178 0988-0033 191 µM 0.637533548369977 0.233097709563267 no 796 0.261888682356315 281 5392207
SGTC_426 0988-0037 14.6 µM 0.635438131195127 0.233779892226326 no 797 0.262571352770619 295 5383008
SGTC_304 1310-0298 97 µM 0.635327995872718 0.233815778393209 no 798 0.262607259167338 313 1550234
SGTC_2218 6965428 192.983 µM 0.634064778951121 0.234227599492393 no 799 0.263019273663531 288 675684
SGTC_318 1488-0629 67.2 µM 0.633388491098102 0.234448240890867 no 800 0.263239989382707 309 3662576
SGTC_2052 5265182 7.135 µM 0.633336605697482 0.234465173442053 no 801 0.263256926793982 285 1239884
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.632846601113774 0.234625117446287 no 802 0.2634169107791 292 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1159 4092-0538 61.2 µM 0.631706505193782 0.234997493316119 no 803 0.263789338243587 304 717301
SGTC_3234 9132280 49.47 µM 0.630544550051277 0.235377344540356 no 804 0.26416918239856 280 17612295
SGTC_319 1348-1596 45.5 µM 0.630170161366335 0.235499806957264 no 805 0.264291629705208 313 5380505
SGTC_2591 skatole 100 µM 0.626354764478106 0.236749824686976 no 806 0.265541136527676 313 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_162 k030-0015 37.8 µM 0.625977667352847 0.236873568812709 no 807 0.265664794835405 320 1809920 YMR134W ERG29
SGTC_2929 9013348 24.6 µM 0.624918432674416 0.237221345993146 no 808 0.266012296943539 300 2995952
SGTC_1289 0976-0073 69.1 µM 0.623116554672085 0.237813598149775 no 809 0.266603965852249 309 3391136
SGTC_1571 st070080 73.4 µM 0.622919552298117 0.237878399222825 no 810 0.266668694345678 294 4315245
SGTC_1146 3579-1023 7 µM 0.621527259960362 0.238336649499224 no 811 0.267126382133338 313 X1146
SGTC_1152 3909-8331 15.9 µM 0.621498173870261 0.238346227863523 no 812 0.267135947821007 315 16001939
SGTC_1491 4138-0063 26.5 µM 0.616858231982223 0.239876907132772 no 813 0.26866411933558 295 23883227
SGTC_1787 fluconazole 80 µM 0.616391562732565 0.240031153749365 no 814 0.268818060286154 282 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_809 3998-0021 90 µM 0.614824798216707 0.240549406485634 no 815 0.269335215288844 307 715485
SGTC_283 0987-0079 11.7 µM 0.612823089404817 0.241212415105839 no 816 0.269996661023518 285 411556
SGTC_1216 1165-0504 9.65 µM 0.610017921971101 0.242143215140561 no 817 0.270924967795527 315 6304004
SGTC_2102 5377816 72.7585 µM 0.608488729368263 0.242651444995692 no 818 0.271431689406824 306 1379702
SGTC_1008 4106-0037 6 µM 0.608142491151901 0.242766598011951 no 819 0.271546486314576 324 2905394
SGTC_1617 st002906 78 µM 0.607945854154569 0.2428320093418 no 820 0.271611692998878 303 5150859
SGTC_3222 9128301 49.47 µM 0.60664437305943 0.243265187618336 no 821 0.272043472888499 281 4911358
SGTC_18 0111-0177 500 nM 0.604831344076016 0.243869322401454 no 822 0.272645532462473 299 721752
SGTC_579 4491-1009 110 µM 0.604305442230947 0.244044713988064 no 823 0.272820294380194 324 1271041
SGTC_577 r071-0003 38.6 µM 0.603856391070843 0.244194529221328 no 824 0.272969562090628 314 4568517 YMR134W ERG29
SGTC_947 3447-0010 211 µM 0.603582981849418 0.244285769982891 no 825 0.273060465034575 316 748350
SGTC_1413 3910-0535 34.4 µM 0.600104649350964 0.245448144119601 no 826 0.274218247106488 291 2876951
SGTC_3038 9091290 49.47 µM 0.59944860661061 0.245667710298832 no 827 0.274436885980879 318 25236843
SGTC_3143 9086658 49.47 µM 0.59778127472026 0.246226211853405 no 828 0.274992943325201 312 25236626
SGTC_1886 st057356 49.9 µM 0.597699875699941 0.246253495277157 no 829 0.275020104208019 300 24207747
SGTC_2303 7774051 200 µM 0.594398195827312 0.247361521376903 no 830 0.276122907448634 329 2953184
SGTC_3062 9077494 49.47 µM 0.593794873370345 0.247564280754955 no 831 0.276324659186097 252 16459633
SGTC_1822 st052468 42 µM 0.592946794293029 0.24784944587148 no 832 0.276608380043166 306 2873678
SGTC_278 4092-0821 23.9 µM 0.592023304575462 0.248160166997043 no 833 0.276917491477936 300 877900
SGTC_1782 st039423 80.636 µM 0.590014225889621 0.248836866842326 no 834 0.277590556067502 309 2068169
SGTC_885 0865-0106 16.8 µM 0.589196320298706 0.249112635697571 no 835 0.277864792650379 307 2793380
SGTC_485 niflumic acid 177 µM 0.587684757117379 0.249622708914813 no 836 0.278371954348791 313 4488 A COX2 inhibitor.
SGTC_2720 fluspirilene 36.88 µM 0.587506569433796 0.249682874436249 no 837 0.278431769831231 307 3396 An atypical antipsychotic.
SGTC_3027 9089541 49.47 µM 0.586568688318974 0.249999679274407 no 838 0.278746708542228 301 9943819
SGTC_928 2764-0428 58.7 µM 0.586464902573043 0.250034749940718 no 839 0.278781570253533 309 662578
SGTC_2412 st077135 33.4 µM 0.585520543127639 0.250353982207406 no 840 0.279098878779594 329 13258915
SGTC_268 camptothecin 39.6153 µM 0.585358138711363 0.250408903333439 no 841 0.279153464999941 314 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1144 3486-0183 12.5 µM 0.585036308261853 0.250517757233775 no 842 0.279261651698099 336 6744069
SGTC_1722 st034304 3.6505 µM 0.58492513437528 0.250555365813366 no 843 0.279299028706456 323 4036148 YLR033W RSC58
SGTC_1055 3448-0672 86 µM 0.584497910356011 0.250699917586846 no 844 0.279442685372706 295 748378
SGTC_2117 5521686 200 µM 0.584107666808154 0.250831995559105 no 845 0.279573938485031 305 803312
SGTC_1644 st010134 20.9 µM 0.583970805498594 0.250878325008083 no 846 0.2796199770137 311 3818134
SGTC_3135 9127742 49.47 µM 0.58373821213943 0.250957071470917 no 847 0.279698227113968 315 3643468
SGTC_2044 5102272 200 µM 0.583431682929435 0.251060869521039 no 848 0.279801367272052 301 592666
SGTC_3238 9133470 49.47 µM 0.582950275114027 0.251223931444881 no 849 0.279963387365534 292 3534688
SGTC_1560 lithocholic acid 53.1 µM 0.581961498770128 0.251559024246406 no 850 0.280296307349305 304 9903 A bile acid which acts as a detergent.
SGTC_3013 9080133 71.4286 µM 0.581352285374998 0.251765602014717 no 851 0.280501524295844 311 17050193
SGTC_2700 st077718 96.8 µM 0.580224256693537 0.25214834086375 no 852 0.280881698957226 306 904970
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.579933090635915 0.252247182983552 no 853 0.280979869831934 299 688669
SGTC_781 4335-2806 94.4 µM 0.579868803462399 0.252269009298684 no 854 0.281001547422737 333 845254
SGTC_3084 9116877 49.47 µM 0.579003502976639 0.252562886724701 no 855 0.281293404770324 297 27241325
SGTC_1883 5-benzylidenerhodanine 20 µM 0.577773488657799 0.252980940185308 no 856 0.281708528196477 292 1273210
SGTC_806 3966-4455 5.86 µM 0.576075931864101 0.253558498028153 no 857 0.282281929394149 309 714982
SGTC_1939 st074455 53.6 µM 0.574496647882195 0.254096437389576 no 858 0.282815884138469 344 1644229
SGTC_506 n9-isopropylolomoucine 153 µM 0.574275835906955 0.254171698548939 no 859 0.282890579144529 306 6610355
SGTC_1611 st001856 99.4 µM 0.573981196702642 0.254272141053196 no 860 0.282990262753439 345 647478
SGTC_1362 1611-0397 101 µM 0.573640993886636 0.254388142073498 no 861 0.283105382612057 303 27816
SGTC_906 1165-0455 526 µM 0.573057666993098 0.254587107119604 no 862 0.283302824532712 324 3252859
SGTC_3344 9148862 3.898 µM 0.572252272473467 0.254861950389648 no 863 0.283575539407666 330 4905352
SGTC_962 1254-0300 21.5 µM 0.571624236736109 0.255076377165748 no 864 0.283788286019907 306 7340576
SGTC_2639 lactacystin 53 µM 0.571042399239226 0.255275114909431 no 865 0.283985451183418 300 3870 A proteasome inhibitor.
SGTC_3247 9135149 49.47 µM 0.570951289241511 0.255306242603376 no 866 0.284016331232393 322 8934436 YOR116C RPO31
SGTC_1029 k015-0030 64.7 µM 0.570110618281354 0.255593551086246 no 867 0.284301336880337 310 2208316
SGTC_213 1246-0773 967 nM 0.56963372003763 0.255756611310357 no 868 0.284463076451847 328 6251622
SGTC_1156 4092-0367 4.88 µM 0.569518529356298 0.25579600525083 no 869 0.284502149848358 319 1357585
SGTC_488 nitrendipine 139 µM 0.569281583626991 0.255877048030241 no 870 0.284582531374683 316 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1447 4239-0816 81.9 µM 0.568980028672063 0.255980208542057 no 871 0.28468484663134 302 1341554
SGTC_53 0973-0023 39.979 µM 0.568914389796021 0.256002666163785 no 872 0.284707119719623 340 674768
SGTC_2404 5161160 200 µM 0.568903946393811 0.256006239354119 no 873 0.284710663531884 321 2831543
SGTC_2239 6685329 187.64 µM 0.568201310153175 0.256246704766592 no 874 0.284949140974724 284 805680
SGTC_3115 9123671 49.47 µM 0.565063233526429 0.257322094195468 no 875 0.286015377514086 321 3286988
SGTC_1906 st060206 94.7 µM 0.564070042389436 0.257662939480204 no 876 0.286353232519154 325 5133468
SGTC_1555 citronellol 128 µM 0.5635466881629 0.257842639469696 no 877 0.286531338728635 326 8842 A terpine precursor.
SGTC_1502 4534-4282 27.7 µM 0.561966393724088 0.258385647053908 no 878 0.287069458089471 335 3278949
SGTC_1507 4075-3230 155 µM 0.560728858427637 0.258811291896437 no 879 0.287491195495965 323 659771
SGTC_1000 4048-0884 8.67 µM 0.560705290649638 0.258819401449774 no 880 0.287499229958352 337 13040088
SGTC_1034 k072-0165 12.7 µM 0.560579048425934 0.25886284299959 no 881 0.287542268847986 340 5835461
SGTC_649 1123-0311 367 µM 0.560257021382291 0.258973673671529 no 882 0.287652069097926 318 693629 YIL048W NEO1
SGTC_1821 st053465 65.6 µM 0.55915717865377 0.259352386820324 no 883 0.288027227329474 297 675086
SGTC_2372 9071633 200 µM 0.557493495491133 0.259925792637332 no 884 0.288595150980565 299 21321366
SGTC_1266 0828-0227 32.9 µM 0.557134645117234 0.260049559852745 no 885 0.288717719166184 317 3913820
SGTC_766 1391-0721 126 µM 0.556618282047867 0.260227706380079 no 886 0.288894130060733 345 1020919 YIL115C NUP159
SGTC_1268 0828-0275 2.46 µM 0.555571805592209 0.260588936114429 no 887 0.289251805016739 331 745337
SGTC_2438 5259590 200 µM 0.554458509269867 0.260973514364541 no 888 0.289632546670844 337 1201127
SGTC_1151 3909-8316 15.3 µM 0.549451498463487 0.262706742154797 no 889 0.291347820386584 330 800431
SGTC_131 0141-0277 33.849 µM 0.547636091838319 0.263336615134541 no 890 0.291970901046581 338 1547771
SGTC_2358 9037157 4 µM 0.546499720687043 0.263731282214738 no 891 0.292361239833192 312 2388925
SGTC_2326 6164455 177.58 µM 0.546106238054369 0.263868010876541 no 892 0.292496456025361 339 2888790
SGTC_1104 tacrolimus 29.8 µM 0.545741844107128 0.263994663926685 no 893 0.292621702111193 332 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2799 7812892 81.82 µM 0.543653472117331 0.264721120157249 no 894 0.29333997794059 327 20205235
SGTC_1094 duloxetine 25.4 µM 0.541786544346269 0.265371404795297 no 895 0.293982780950471 298 60834 A selective serotonin reuptake inhibitor.
SGTC_1335 1486-0900 202 µM 0.541570068256061 0.265446859744149 no 896 0.294057358079227 315 X1335
SGTC_838 0109-0203 71.4 µM 0.541560658128259 0.265450139987038 no 897 0.294060600115075 299 759422
SGTC_3147 9097027 49.47 µM 0.541439161329174 0.265492493969925 no 898 0.294102460432821 356 25236841
SGTC_3250 9135583 49.47 µM 0.539920457932429 0.266022205572554 no 899 0.294625944341491 307 7699353
SGTC_841 0251-0215 91.2 µM 0.539835581912554 0.266051825437336 no 900 0.294655213048655 340 3888614
SGTC_1114 scopoletin 1.73284 µM 0.538542689551895 0.26650322286159 no 901 0.295101220689095 323 5280460 A coumarin with genotoxic properties.
SGTC_244 nsc-207895 1.295 µM 0.536973517086229 0.267051599968994 no 902 0.295642953641606 312 42640
SGTC_562 3772-2733 112 µM 0.536756130820565 0.267127614636724 no 903 0.295718038982337 328 2876874 YIL048W NEO1
SGTC_2803 7707263 71.43 µM 0.536227141843212 0.267312634781596 no 904 0.295900788674735 324 2199229
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.535152497665855 0.267688703272567 no 905 0.296272205343554 309 6312947
SGTC_1985 st071382 65.5 µM 0.534009079987895 0.26808913141093 no 906 0.296667625994586 331 6123237
SGTC_2629 bisabolol 100 µM 0.533585048336352 0.268237705108242 no 907 0.296814327494711 366 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_980 1473-0395 201 µM 0.532063942586698 0.268771016102405 no 908 0.297340854826533 335 768876
SGTC_909 3448-9333 149 µM 0.531925760788327 0.268819490045765 no 909 0.297388707280578 337 3344074
SGTC_1241 0364-0022 50.8 µM 0.531226321483205 0.269064919523245 no 910 0.297630977552674 336 4563895
SGTC_1786 berberine 21.6 µM 0.530455166616391 0.269335643881148 no 911 0.297898192857747 336 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_934 2950-0684 338 µM 0.529692648448967 0.269603470444638 no 912 0.298162522933724 351 1121253
SGTC_95 0471-0001 561.058 µM 0.529656411777766 0.26961620151843 no 913 0.298175087184427 304 4015405
SGTC_746 1095-0025 46.6 µM 0.52938452216797 0.269711734433079 no 914 0.298269366483139 338 6749286
SGTC_2092 5303694 80.6725 µM 0.529100327675219 0.269811608991149 no 915 0.29836792707744 329 1963699
SGTC_1657 st012939 43.4 µM 0.528360768705823 0.27007159919281 no 916 0.298624480642975 312 24207257
SGTC_775 4577-0580 57.3 µM 0.527675084478995 0.270312761780546 no 917 0.298862434600284 334 2006902
SGTC_1605 st000082 49.1 µM 0.525753276308511 0.270989255795001 no 918 0.299529821020619 345 1114022
SGTC_2690 usnic acid 100 µM 0.525621454294212 0.271035689282839 no 919 0.299575623604192 348 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2315 7733312 200 µM 0.525430592228486 0.271102926295237 no 920 0.29964194573658 314 726316
SGTC_1056 3448-1962 115 µM 0.525231748473279 0.271172983948689 no 921 0.299711048478673 337 715507
SGTC_2172 5754775 163.918 µM 0.524815165420695 0.271319785889318 no 922 0.299855843991988 323 2263357
SGTC_1764 st044502 93.5 µM 0.524810421259713 0.27132145793777 no 923 0.299857493144996 315 8407
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.523468670878698 0.271794555074708 no 924 0.300324073648966 320 6708514
SGTC_2723 salbutamol 83.58 µM 0.52102484769657 0.272657293175657 no 925 0.301174731010383 337 9884233 β2-adrenoceptor agonist
SGTC_1396 3511-0007 98.6 µM 0.520793868620692 0.272738905511022 no 926 0.301255187401411 328 X1396
SGTC_3355 9151058 44.0485 µM 0.520633885354892 0.272795439847667 no 927 0.301310919664909 321 17015728
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.520455651272493 0.272858430440458 no 928 0.301373015305951 311 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1318 1280-3875 124 µM 0.519369510182611 0.273242444821646 no 929 0.301751544535351 335 373245
SGTC_1420 4'-methoxyflavone 42 µM 0.518418775348426 0.273578804778249 no 930 0.302083058876089 332 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1699 st031318 29.054 µM 0.516815784807486 0.274146389508585 no 931 0.302642380025867 346 5340658
SGTC_2895 9054447 58.44 µM 0.516256093175769 0.274344701283833 no 932 0.302837778854232 341 2697450
SGTC_372 0155-0182 15.9 µM 0.516216382124318 0.274358774524066 no 933 0.302851644871741 309 771486
SGTC_735 3076-0345 636 µM 0.516103371714043 0.274398826349303 no 934 0.302891106584237 320 2888990
SGTC_1663 st014140 55.4 µM 0.515793115111385 0.274508798693793 no 935 0.302999455841665 336 4207120
SGTC_2415 st077333 57.7 µM 0.515531040272612 0.274601709658577 no 936 0.303090992349245 375 2766255
SGTC_117 lucigenin 22.078 µM 0.514754261582785 0.27487718490285 no 937 0.30336237530826 349 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3244 9134489 49.47 µM 0.514458960577265 0.2749819455809 no 938 0.3034655730196 355 16584271
SGTC_1174 0739-0097 51.1 µM 0.514358048907028 0.275017749409244 no 939 0.303500841829238 349 728447
SGTC_1960 st011366 51.8 µM 0.51395376460808 0.275161213978174 no 940 0.303642158272514 328 3972846
SGTC_3025 9087895 49.47 µM 0.512064326726907 0.275832189190165 no 941 0.304302995041087 334 17173641
SGTC_3288 9119690 36.221 µM 0.511953209151875 0.275871674163468 no 942 0.304341878691035 357 17595618 YKL019W RAM2
SGTC_1810 st050138 53 µM 0.511931299497205 0.275879459957446 no 943 0.304349545852185 372 3444541
SGTC_1893 st059353 36.1 µM 0.511888309446987 0.275894737174381 no 944 0.304364590229807 367 3112488
SGTC_1142 3253-1408 9.78 µM 0.510298442161822 0.276460014204607 no 945 0.304921196989076 346 256655
SGTC_638 3970-0837 4.09 µM 0.509855527881637 0.276617593386256 no 946 0.305076340171531 326 4118451 YLR208W SEC13
SGTC_560 2332-1943 155 µM 0.50979187972762 0.276640241619836 no 947 0.305098637607317 329 21177716
SGTC_2373 9071805 200 µM 0.508995201946866 0.276923804220095 no 948 0.305377793634965 348 10149009
SGTC_2194 5927483 104.545 µM 0.508717240331335 0.277022772953047 no 949 0.305475218081282 287 760979
SGTC_681 1642-0006 26.6 µM 0.508577259102848 0.27707262007514 no 950 0.305524286164407 348 4446530
SGTC_2710 st078562 53.7235 µM 0.508556113097706 0.277080150519992 no 951 0.305531698847282 349 17250908
SGTC_1655 st012546 55.1 µM 0.508372596036878 0.277145508210198 no 952 0.305596033673379 346 720985 YLR208W SEC13
SGTC_2135 5326629 150.42 µM 0.507899197994792 0.277314138811735 no 953 0.305762018599239 330 5020077
SGTC_285 1486-1325 46 µM 0.506955836019725 0.277650326286845 no 954 0.306092903360188 336 22310230
SGTC_2203 7227154 166.4 µM 0.506896842809718 0.277671356407804 no 955 0.306113600523702 328 896304
SGTC_1340 1486-1359 257 µM 0.506675780493152 0.277750168452208 no 956 0.30619116347796 332 4309068
SGTC_2248 tofa 1.1 µM 0.505770990391401 0.278072853554538 no 957 0.306508712868972 334 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_785 1270-0111 65.3 µM 0.503918436481856 0.278734119963939 no 958 0.307159347164027 325 6741994
SGTC_1525 8-methoxypsoralen 92.5 µM 0.503709307525979 0.278808816296392 no 959 0.307232833415364 375 4114 Related to psoralen; DNA damaging agent.
SGTC_1310 1188-0297 994 nM 0.503216080004096 0.278985025055462 no 960 0.307406180298127 321 1588352
SGTC_1756 st041558 35.5 µM 0.502535812504847 0.279228143909916 no 961 0.307645333760008 351 3955792
SGTC_1602 st001878 87.6 µM 0.502085250764762 0.27938922554589 no 962 0.307803777351597 356 595405 YLR310C CDC25
SGTC_1330 1469-0054 61.8 µM 0.502030545684986 0.279408786390428 no 963 0.307823017265519 359 7102664
SGTC_561 1550-0330 72.9 µM 0.498231126385666 0.280768966226899 no 964 0.309160572944775 341 6812934
SGTC_1428 4049-0204 61.7 µM 0.497802972405919 0.28092244448791 no 965 0.309311460345329 355 X1428
SGTC_293 4049-0273 38.5 µM 0.497506497849086 0.281028744026901 no 966 0.309415960938682 328 1380311
SGTC_3156 9099931 49.47 µM 0.495179734047997 0.281863668193661 no 967 0.31023662735002 338 18111053
SGTC_1035 k081-0041 55.2 µM 0.488495175954352 0.284268948568798 no 968 0.312599570922952 348 731709
SGTC_2880 9042983 58.44 µM 0.486924728060231 0.284835457243268 no 969 0.313155837163958 351 6464714
SGTC_2370 9071495 200 µM 0.485760921227514 0.285255625227695 no 970 0.313568342200465 358 21791103
SGTC_345 1362-0200 395 µM 0.485400127034974 0.285385942322973 no 971 0.313696271137705 325 1419823
SGTC_1086 cerivastatin 2.18 µM 0.485214568757044 0.285452976103187 no 972 0.313762074363027 324 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_146 3448-8650 53.125 µM 0.484495939995308 0.285712654758543 no 973 0.31401697250957 377 2891488 YIL048W NEO1
SGTC_1553 gossypol 38.6 µM 0.48085494798125 0.287030062264115 no 974 0.315309797096365 358 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2993 9054257 71.4286 µM 0.480777376152962 0.287058161081663 no 975 0.315337365593137 337 6470217 YGL055W OLE1
SGTC_108 0509-0257 621.132 µM 0.48029369760613 0.287233393177629 no 976 0.315509284825084 341 536624
SGTC_2206 7254556 146.969 µM 0.480222157217003 0.287259315871321 no 977 0.315534716610889 328 4398905
SGTC_2824 7998404 51.95 µM 0.479666999470764 0.287460515163966 no 978 0.315732098496637 361 837851
SGTC_2327 6189656 200 µM 0.479489223409811 0.287524958535724 no 979 0.31579531646416 374 5349088
SGTC_1640 st009078 66.4 µM 0.477793271858436 0.28814007982098 no 980 0.316398675178079 360 690618
SGTC_2702 st077768 96.8 µM 0.477459724346242 0.288261130463768 no 981 0.316517397014515 304 6484119
SGTC_2841 9004761 38.96 µM 0.476623491808116 0.288564720319642 no 982 0.31681512605907 309 2991039
SGTC_3316 9136639 10.545 µM 0.476313409606114 0.288677332317068 no 983 0.316925556717838 334 4903665
SGTC_2795 7780010 54.55 µM 0.475913480176036 0.288822604525407 no 984 0.317068009068458 337 953673
SGTC_3020 9089140 49.47 µM 0.475678909155595 0.288907827191749 no 985 0.31715157440978 336 17217859
SGTC_1062 mesoridazine 14.2 µM 0.474706224507672 0.289261342238449 no 986 0.317498190353056 339 4078 A neuroleptic.
SGTC_2792 7535235 81.82 µM 0.474497407323853 0.289337261801789 no 987 0.317572623187984 324 1281891
SGTC_1937 st074714 47.2 µM 0.473831529356074 0.289579417246773 no 988 0.317810024474926 345 17250970
SGTC_674 0498-0004 451 µM 0.473695698181931 0.289628825755637 no 989 0.317858460711994 338 4231473
SGTC_2173 5763948 167 µM 0.473195172474742 0.289810925834307 no 990 0.318036970802493 344 2867177
SGTC_1798 st045719 60.953 µM 0.472294963124128 0.290138572974918 no 991 0.318358132536044 376 3980186
SGTC_1225 1216-0074 20.6 µM 0.472200419201299 0.290172993980524 no 992 0.31839187027442 341 4241466
SGTC_311 1315-0136 58 µM 0.470839097910802 0.290668827963072 no 993 0.318877820892387 351 6759207
SGTC_1364 1653-0028 37.6 µM 0.470673266135412 0.290729255930317 no 994 0.318937039135061 332 5718652
SGTC_2937 9044753 11.33 µM 0.470111408810326 0.290934036564629 no 995 0.319137711776074 346 6465530 YGL099W LSG1
SGTC_2628 lathosterol 100 µM 0.469775061822399 0.291056657492597 no 996 0.319257866643207 331 6710616
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.469236041100103 0.291253216853617 no 997 0.319450463223154 355 140250 A respiratory chain inhibitor.
SGTC_2342 7990637 118.86 µM 0.468738436601605 0.291434728356097 no 998 0.319628304691364 372 2033102 YER133W GLC7
SGTC_2528 xanthyletin 44.79 µM 0.468594995280822 0.291487061332692 no 999 0.319679577638048 364 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2340 7987427 183.45 µM 0.468214229271947 0.291626000848224 no 1000 0.319815698755403 326 2239331
SGTC_1750 st081859 2.357 µM 0.466183121633837 0.292367662432632 no 1001 0.320542214815596 368 5291695
SGTC_3015 9080845 49.47 µM 0.465123445889299 0.292754952240402 no 1002 0.320921528368245 356 5296973
SGTC_1836 st055642 81 µM 0.463653186383448 0.293292696231241 no 1003 0.321448121045287 382 8571
SGTC_647 0140-0236 81 µM 0.46295074661545 0.293549773450412 no 1004 0.321699835858382 353 990837
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.461167984641143 0.294202692405704 no 1005 0.32233904458426 364 4620898
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.457398550530001 0.295585414764272 no 1006 0.323692303001586 380 688798
SGTC_2630 antimycin a 100 µM 0.45436546379825 0.29670019105319 no 1007 0.32478290276354 354 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_757 1066-0008 322 µM 0.452392633831746 0.297426313872702 no 1008 0.32549307631521 353 6842497
SGTC_810 3825-7150 143 µM 0.450706630687319 0.298047509200091 no 1009 0.326100501394227 332 22330411 YGL099W LSG1
SGTC_2075 5212009 200 µM 0.450553619043584 0.298103914453937 no 1010 0.326155650566263 383 780898
SGTC_3077 9117319 49.47 µM 0.449064539523802 0.298653093176168 no 1011 0.326692549958411 364 17154678
SGTC_2787 5284540 71.43 µM 0.448835792056798 0.298737496939157 no 1012 0.3267750585122 365 736958
SGTC_280 3448-3607 3.04 µM 0.448780837747004 0.29875777572117 no 1013 0.326794881635979 356 626179
SGTC_412 gemfibrozil 100 µM 0.448703878319504 0.298786175700162 no 1014 0.326822643269604 356 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_696 1560-0013 611 µM 0.446732489108396 0.29951408613442 no 1015 0.327534110463301 336 1650269
SGTC_1003 4049-0218 100 µM 0.44648915438259 0.29960399009692 no 1016 0.327621972587884 356 295161
SGTC_2086 5274770 176.623 µM 0.445324943186542 0.300034295913842 no 1017 0.328042472354842 357 689278
SGTC_176 1486-1328 72.834 µM 0.444382907835474 0.300382687506376 no 1018 0.328382884382904 344 22310231
SGTC_610 4215-0184 155 µM 0.44429150890196 0.300416499169259 no 1019 0.328415919709745 342 5605015
SGTC_1389 3405-0187 19 µM 0.443012630647938 0.3008897812047 no 1020 0.32887829942185 346 799890
SGTC_49 0717-0965 32.132 µM 0.442994134405091 0.300896628684912 no 1021 0.328884988680748 374 5889349 YGL099W LSG1
SGTC_2658 polymyxin b sulfate 77.05 µM 0.441368977934758 0.301498550784074 no 1022 0.329472948430952 354 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1184 1269-1718 139 µM 0.438749370672802 0.302469934285865 no 1023 0.330421574678935 338 5403821
SGTC_3146 9095609 49.47 µM 0.438271074458097 0.30264744395784 no 1024 0.330594895803988 352 17173999
SGTC_2018 5133068 143 µM 0.4373539722996 0.302987937796888 no 1025 0.33092732949239 358 785362
SGTC_2507 purpurin 79.67 µM 0.43723993390174 0.303030288977926 no 1026 0.330968675768878 356 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_364 0083-0097 67.7 µM 0.437121902830708 0.303074125733163 no 1027 0.331011471818179 338 5207356
SGTC_1409 3909-8004 61.9 µM 0.436695200848656 0.303232626566047 no 1028 0.33116620508179 353 2119279
SGTC_972 1319-0219 195 µM 0.435843841152117 0.303548979560229 no 1029 0.331475016443098 379 23903702
SGTC_1240 0356-0016 42.1 µM 0.435028937937205 0.303851923827777 no 1030 0.331770711399777 347 4305613
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.434214753158646 0.304154735622775 no 1031 0.332066250371161 358 229346 A bile salt which induces apoptosis.
SGTC_3186 9110464 49.47 µM 0.433447889867406 0.304440070496233 no 1032 0.332344707799278 373 17018021
SGTC_3203 9113543 49.47 µM 0.431484176717693 0.305171272389098 no 1033 0.33305817775329 358 17018012
SGTC_308 4092-1169 104 µM 0.429950513531609 0.30574288378386 no 1034 0.333615819688541 379 2268590 YDL196W YDL196W
SGTC_350 k064-0020 19.8 µM 0.429684190420371 0.305842193337208 no 1035 0.333712692632314 345 2790705
SGTC_2673 kobusone 100 µM 0.427242041327496 0.306753514351811 no 1036 0.334601521439816 372 6710676 An epoxy ketone and protein crosslinker.
SGTC_193 1273-0060 1.558 µM 0.426856960754097 0.306897321667993 no 1037 0.334741757678196 356 2847393 YHR072W ERG7
SGTC_738 1315-0003 72.4 µM 0.426230235093946 0.307131434237523 no 1038 0.334970043999022 382 6251474
SGTC_2523 spermine 47.74 µM 0.425537558518745 0.307390274178471 no 1039 0.335222424050312 352 1103 A DNA binding polyamine.
SGTC_2081 5214970 32.255 µM 0.424691744429448 0.307706468790358 no 1040 0.335530701377804 353 2063512
SGTC_2991 9074669 71.4286 µM 0.423372196158879 0.308200046938715 no 1041 0.336011863655617 391 17333109
SGTC_1130 3454-2858 15.9 µM 0.422829932276465 0.308402981861494 no 1042 0.336209673651328 415 715628 YIL048W NEO1
SGTC_1905 st060207 84.5 µM 0.421793675154357 0.308790949908976 no 1043 0.336587811337959 361 1948547
SGTC_1733 st037357 54.9 µM 0.42134744631366 0.308958080919976 no 1044 0.336750694395886 382 1272339 YGL099W LSG1
SGTC_663 1486-0733 13.9 µM 0.420614905356086 0.309232533333074 no 1045 0.337018153889011 371 722445 YPR165W RHO1
SGTC_3208 9114115 49.47 µM 0.418625402792162 0.309978453589733 no 1046 0.337744960703617 388 650895
SGTC_1855 st056195 39.6 µM 0.417260749430679 0.310490553238725 no 1047 0.338243847357317 363 4028379
SGTC_2446 5162541 200 µM 0.416268641143107 0.31086308246184 no 1048 0.338606718317499 361 1549321
SGTC_1791 st048313 56.1 µM 0.416242229637545 0.310873002435983 no 1049 0.338616380571022 364 1204976
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.416240196642451 0.310873766020217 no 1050 0.338617124316215 401 1273210
SGTC_2460 5552655 174.22 µM 0.415246973237483 0.311246913807807 no 1051 0.338980557580173 345 5401989
SGTC_1911 st060208 74.3 µM 0.414378733795603 0.311573264891156 no 1052 0.339298380420099 378 688783
SGTC_2452 5863136 48.41 µM 0.413131692210388 0.312042257964502 no 1053 0.33975506548538 361 2184096
SGTC_1623 st003709 20.3 µM 0.412486540558561 0.312285009233092 no 1054 0.339991421966223 348 16192618
SGTC_1837 st055472 66.5 µM 0.411116724989735 0.31280070001493 no 1055 0.340493473362743 350 676091
SGTC_445 e6 berbamine 66 µM 0.41089432943235 0.312884459288147 no 1056 0.340575010311768 365 6610268 A calcium/calmodulin antagonist.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.408334608523257 0.313849203530458 no 1057 0.341514017134035 405 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_357 1325-0123 420 µM 0.4079416693063 0.313997413044539 no 1058 0.341658249842598 390 1098503
SGTC_2292 7671323 168.05 µM 0.407560599199947 0.314141174409669 no 1059 0.341798147947065 401 937504
SGTC_1635 st007035 42.4 µM 0.406943430503262 0.314374065444715 no 1060 0.34202476843356 350 3716403
SGTC_1830 st055982 50.3 µM 0.406760350783436 0.314443165514264 no 1061 0.342092005112798 401 455313 An antimicrobial agent.
SGTC_329 k048-0121 21.3 µM 0.40663690932447 0.314489759890085 no 1062 0.34213734225468 357 6832902
SGTC_2390 9097792 176.6 µM 0.406549667244213 0.314522692183016 no 1063 0.342169385589563 369 4497149
SGTC_1720 st037298 9.481 µM 0.406444070505132 0.314562554998858 no 1064 0.342208171967663 396 597396
SGTC_1168 k815-0004 80.5 µM 0.406425161844078 0.31456969325501 no 1065 0.342215117419212 380 642433
SGTC_1531 st059297 52.4 µM 0.406342404212939 0.31460093611183 no 1066 0.342245516239648 362 7566702
SGTC_754 3474-0146 171 µM 0.406225315656715 0.314645141928562 no 1067 0.342288527360994 343 24762078
SGTC_2043 5101342 149 µM 0.405825493775258 0.314796111398641 no 1068 0.342435412703308 372 678451
SGTC_2453 5731132 22.18 µM 0.403987527875591 0.315490510228419 no 1069 0.343110945330915 378 1362040
SGTC_2584 androsterone 48.74 µM 0.403494705264372 0.315676813683771 no 1070 0.343292164523626 353 2754130 A steroid.
SGTC_36 0335-0881 14.2 µM 0.403005896042947 0.315861646223311 no 1071 0.34347194352548 360 23828853
SGTC_2411 st077133 39.94 µM 0.402604684299953 0.316013390102224 no 1072 0.343619531544307 410 1403142 YNL221C POP1
SGTC_1286 0929-0070 131 µM 0.402275280740111 0.316137998302534 no 1073 0.343740722338831 357 1420408
SGTC_2282 7944268 200 µM 0.400044157325172 0.316982546558961 no 1074 0.34456199670896 370 2970414
SGTC_149 3970-0822 46.1 µM 0.399559360739648 0.317166183221831 no 1075 0.344740546968381 374 3114250 YBL034C STU1
SGTC_2561 acetosyringone 100 µM 0.398397119247893 0.317606613344334 no 1076 0.345168740530601 390 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_818 4072-2707 53.5 µM 0.397589755358514 0.317912715059096 no 1077 0.345466306676288 369 882871
SGTC_476 mead acid 10 µM 0.396507919593069 0.318323074380894 no 1078 0.345865183316222 390 5312531 An omega 9 fatty acid.
SGTC_659 k018-0002 107 µM 0.394340383398439 0.319145929698656 no 1079 0.346664876056435 382 6797879 YHR007C ERG11
SGTC_2006 4011487 200 µM 0.392716444494988 0.319763005485566 no 1080 0.347264461786362 368 45595294
SGTC_65 0798-0905 34.986 µM 0.392108928173482 0.319993982234772 no 1081 0.347488865480795 410 3602145
SGTC_2533 agelasine 13.65 µM 0.391818940943571 0.320104259537761 no 1082 0.34759599949158 391 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_721 1187-1332 279 µM 0.390545587071024 0.320588682788143 no 1083 0.348066576288992 380 25730
SGTC_3229 9132204 49.47 µM 0.390513070665428 0.320601057042819 no 1084 0.348078596021055 387 17682924
SGTC_1701 st028638 40.4 µM 0.390397950211667 0.320644868217316 no 1085 0.348121151674739 376 3490878
SGTC_545 4218-0007 221 µM 0.38989812797624 0.32083511359339 no 1086 0.348305939119598 386 2840508
SGTC_900 1112-0045 141 µM 0.38959632369628 0.320950010961546 no 1087 0.348417535514003 370 56211 YIL048W NEO1
SGTC_2210 7115885 190.385 µM 0.389057717324576 0.321155101865768 no 1088 0.348616725426247 389 2927039
SGTC_1728 st035614 33.7865 µM 0.388845545691169 0.321235907709607 no 1089 0.348695203189818 385 15945546
SGTC_808 0711-0032 135 µM 0.386961683867754 0.321953749778086 no 1090 0.349392287137053 399 4252555
SGTC_2865 9030313 51.95 µM 0.386508439439964 0.322126557058859 no 1091 0.349560076770217 362 42562754
SGTC_2459 5811157 9.22 µM 0.385579268057793 0.322480939936764 no 1092 0.34990414490698 382 2870684 YBR192W RIM2
SGTC_3165 9101544 49.47 µM 0.384739839377127 0.322801233998045 no 1093 0.350215087721537 388 5002184
SGTC_1548 st061468 90.8 µM 0.384474101760407 0.322902656780449 no 1094 0.350313543709149 391 390799
SGTC_983 1491-0821 12.2 µM 0.384250813798496 0.322987888194157 no 1095 0.350396279845444 354 46495113
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.383272709071389 0.323361350777237 no 1096 0.35075878606635 409 442882
SGTC_1963 st076565 50.3 µM 0.380768339907145 0.324318386634672 no 1097 0.351687576893399 394 4914280
SGTC_1244 0416-0015 52.5 µM 0.379602421666673 0.32476433491562 no 1098 0.352120281460147 387 96201
SGTC_1203 3992-3522 103 µM 0.379547500792599 0.324785347624286 no 1099 0.352140668846371 414 5322312
SGTC_3303 9125618 40.5795 µM 0.379304564561666 0.324878301634799 no 1100 0.352230855224064 390 22695467
SGTC_2090 5301565 104.445 µM 0.379235645465722 0.324904673941484 no 1101 0.352256441902807 382 2056344
SGTC_513 4245-1575 41.7 µM 0.379101581697838 0.324955976762362 no 1102 0.352306215895567 378 719745
SGTC_3232 9132874 49.47 µM 0.379076195544897 0.324965691776308 no 1103 0.352315641323531 374 3784940
SGTC_336 4111-0029 111 µM 0.378889804983847 0.325037025129968 no 1104 0.352384847607765 400 3131175
SGTC_3274 9138298 49.47 µM 0.378414643943818 0.325218902570311 no 1105 0.352561295655055 375 17015756
SGTC_1978 st071761 42 µM 0.377560309867712 0.325546020845983 no 1106 0.352878627000418 363 5147680
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.377136585727929 0.325708311603594 no 1107 0.353036051844607 388 756377
SGTC_231 b-estradiol 524 µM 0.375154813015462 0.32646778938592 no 1108 0.353772666990129 361 450 A steroid.
SGTC_1108 betulinic acid 729.144 nM 0.374792734035593 0.326606627340125 no 1109 0.353907309226688 358 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2620 irigenin 100 µM 0.374048597075728 0.3268920395173 no 1110 0.35418408041595 420 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_118 0083-0097 135.343 µM 0.372640701277821 0.327432312053161 no 1111 0.354707937972643 387 5207356
SGTC_584 0986-0246 15.4 µM 0.3715146094814 0.32786470417762 no 1112 0.355127138277477 405 53315 YDR232W HEM1
SGTC_2724 maprotiline 69.64 µM 0.37062834972174 0.328205168962213 no 1113 0.355457181791744 399 4011 A tricyclic antidepressant.
SGTC_1063 disulfiram 1.84 µM 0.368981008220334 0.328838389382692 no 1114 0.356070940381856 373 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_82 0054-0107 293.755 µM 0.36778903793276 0.329296876684364 no 1115 0.356515271734484 364 3104697
SGTC_3177 9107506 49.47 µM 0.367667320376573 0.329343709389445 no 1116 0.356560655420739 411 8897194
SGTC_1353 1498-1206 8.11 µM 0.366842940997004 0.329660972504695 no 1117 0.356868087478616 397 6756808
SGTC_331 k048-0133 24.5 µM 0.366089773839004 0.329950936736065 no 1118 0.357149043975872 374 6813582
SGTC_2713 st079149 53.4 µM 0.362792648923598 0.331221508473844 no 1119 0.358379891808426 381 3103253
SGTC_41 0478-0632 82.643 µM 0.36243927126672 0.331357800885084 no 1120 0.358511898633926 428 3750424
SGTC_2778 tioconazole 65.09 nM 0.362419638684747 0.331365373529833 no 1121 0.35851923302538 393 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1975 st070967 30.8 µM 0.361885487220757 0.331571431935003 no 1122 0.358718802746827 425 261391
SGTC_323 4013-0906 34.3 µM 0.360113161168982 0.332255503098022 no 1123 0.359381255482745 394 2910086
SGTC_731 3966-0296 387 µM 0.357534068891724 0.333251963438099 no 1124 0.360346013024269 384 660956
SGTC_3066 9117245 49.47 µM 0.355710326884427 0.333957297582477 no 1125 0.361028755245559 395 17176980
SGTC_15 0266-0086 27.098 µM 0.354918735942823 0.334263629044857 no 1126 0.361325235910814 412 1712902 YIL048W NEO1
SGTC_87 0100-0052 35.5 µM 0.354330734134523 0.334491246657715 no 1127 0.361545518699949 386 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1958 st076513 41.9 µM 0.353757210862335 0.334713318203105 no 1128 0.361760421622373 406 732122 YGL099W LSG1
SGTC_2856 9022925 19.48 µM 0.351567439984287 0.335561741527403 no 1129 0.362581343647456 374 4944862
SGTC_3293 9120939 62.045 µM 0.35140143175928 0.335626095426624 no 1130 0.362643604206666 407 934087
SGTC_3113 9123498 49.47 µM 0.350706067499295 0.33589570915661 no 1131 0.362904436567398 419 8897275
SGTC_1134 3477-0009 42.5 µM 0.350698084638357 0.335898804843654 no 1132 0.362907431322186 426 3973534
SGTC_208 k072-0098 12.366 µM 0.3503965954886 0.336015727975756 no 1133 0.363020540527715 379 5948901
SGTC_1328 1441-0025 69.2 µM 0.348966959701651 0.336570383363811 no 1134 0.36355705724186 389 4562601
SGTC_3106 9121286 49.47 µM 0.348487699187772 0.336756401611196 no 1135 0.363736975100009 353 15943471
SGTC_748 act1.228 77.9 µM 0.346411480338556 0.337562717689591 no 1136 0.364516749274265 354 4421505 YNR035C ARC35
SGTC_952 1185-0122 232 µM 0.344938127567058 0.338135358919465 no 1137 0.365070443021877 390 678600
SGTC_2842 9000675 19.48 µM 0.344687154776388 0.338232940741492 no 1138 0.365164788006691 387 2989072
SGTC_523 1934-0222 13.7 µM 0.343479000486528 0.338702840437559 no 1139 0.365619068086976 436 1361595
SGTC_2202 7226349 200 µM 0.341238753070737 0.339574826830765 no 1140 0.366461925729924 371 844334
SGTC_3103 9120822 49.47 µM 0.341159131919469 0.339605834143445 no 1141 0.366491893811996 429 17141819
SGTC_2197 6588183 93.1375 µM 0.339551629088981 0.34023208497682 no 1142 0.367097105137862 385 884136
SGTC_613 3914-0030 117 µM 0.339147713700154 0.340389511690029 no 1143 0.367249227891322 408 1145395
SGTC_1422 4031-0024 15.5 µM 0.33863697711774 0.340588611970424 no 1144 0.367441611513208 421 782427
SGTC_408 cantharidin 100 µM 0.338319459504155 0.340712412161127 no 1145 0.367561230430889 381 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_317 4495-0002 170 µM 0.337342658718162 0.341093374559475 no 1146 0.36792930267955 391 15991618
SGTC_1954 st077032 68.9 µM 0.337198008480536 0.341149803431402 no 1147 0.367983819239142 419 698907
SGTC_1656 st012921 11 µM 0.336593331766666 0.341385729676417 no 1148 0.368211741831701 408 6732821
SGTC_1953 st076800 12.1 µM 0.336216263663019 0.341532881438832 no 1149 0.368353894724041 383 297591
SGTC_1341 1486-1360 280 µM 0.335097114630438 0.341969773908892 no 1150 0.368775914677994 404 3976547
SGTC_371 0195-0006 7.36 µM 0.335050999777323 0.341987780731894 no 1151 0.36879330752876 380 3928593
SGTC_707 0865-0008 204 µM 0.335029263450145 0.341996268408147 no 1152 0.368801505776542 407 723043
SGTC_1966 st070145 16.1 µM 0.333450100686293 0.342613118731224 no 1153 0.369397274998883 392 3748532
SGTC_2465 5809242 33.21 µM 0.332731383767535 0.342894002077907 no 1154 0.369668528629996 405 2731748
SGTC_917 harmaline 728.087 nM 0.33207352536246 0.343151177316977 no 1155 0.369916870293427 369 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3275 9138069 49.47 µM 0.330147543830315 0.3439045147401 no 1156 0.370644240257644 424 17617007
SGTC_2616 abietic acid 100 µM 0.329500179640632 0.344157867193926 no 1157 0.370888829095334 414 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_827 3253-0474 693 µM 0.32826787493664 0.344640335250182 no 1158 0.371354565815763 378 5402065
SGTC_2567 aureobasidin a 60 nM 0.328009387419218 0.344741569572249 no 1159 0.371452282409456 402 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_129 0088-0017 176.636 µM 0.327948897212808 0.34476526162565 no 1160 0.371475150849184 413 182446
SGTC_1208 2323-2347 50.3 µM 0.32572989579494 0.345634792677103 no 1161 0.372314361584979 428 5412760
SGTC_1949 st076024 69.1 µM 0.324589378804163 0.346082029568577 no 1162 0.372745933415085 431 2921930
SGTC_3311 9131146 2.8755 µM 0.32406441210732 0.346287959724934 no 1163 0.372944634640154 401 4900406 YPR165W RHO1
SGTC_2942 9052777 62.25 µM 0.322596561418836 0.346863998676156 no 1164 0.373500399103672 419 6469503
SGTC_3279 9140807 49.47 µM 0.322197000128498 0.347020862694068 no 1165 0.37365172848429 427 45595718
SGTC_1943 st076331 65.2 µM 0.321588697806923 0.347259726820091 no 1166 0.373882153603605 401 24208415
SGTC_724 3910-0327 137 µM 0.316534353677483 0.349246772155851 no 1167 0.375798477051181 425 2885483
SGTC_473 2-arachidonoylglycerol 10 µM 0.316267633438599 0.349351744975095 no 1168 0.375899688004402 390 5282280 An endocannabinoid.
SGTC_759 3486-0358 89.3 µM 0.314182432576968 0.350172812074854 no 1169 0.376691242207937 431 875103
SGTC_905 2-aminofluorene 215 µM 0.311287050498076 0.351314057121555 no 1170 0.377791205406709 388 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2365 9042475 200 µM 0.309760836679454 0.351916171021765 no 1171 0.378371417745792 388 6464479
SGTC_2539 epi(13)torulosol 80 µM 0.309626005654476 0.351969381736399 no 1172 0.378422688925035 389 6708597
SGTC_3300 9124615 50.48 µM 0.309604587995561 0.351977834426851 no 1173 0.378430833454051 393 24824903
SGTC_194 1486-1323 56.904 µM 0.309452280736261 0.352037946099232 no 1174 0.378488753147959 406 5178754
SGTC_322 k048-0136 19.3 µM 0.30924408863899 0.352120120030089 no 1175 0.378567929250171 401 6823282
SGTC_1430 4049-0248 69.1 µM 0.308504149653147 0.352412231625106 no 1176 0.378849371582099 422 22774488
SGTC_1488 4013-0813 75.9 µM 0.307882212445587 0.352657826081341 no 1177 0.37908598060085 404 2910057
SGTC_1390 3413-2614 145 µM 0.306097858053272 0.353362783719555 no 1178 0.379765069366901 439 3421432
SGTC_2319 6033012 152.6 µM 0.305206793459196 0.353715011589511 no 1179 0.380104329336576 380 847246
SGTC_2354 9060492 162 µM 0.304104831587591 0.354150778025954 no 1180 0.380524012993083 418 6471895
SGTC_705 1124-0212 310 µM 0.303339388435049 0.354453581966718 no 1181 0.38081561586096 448 9554485
SGTC_3055 9094636 49.47 µM 0.302404946386023 0.35482336540957 no 1182 0.381171692245451 416 25236176
SGTC_490 phenamil 164 µM 0.302106533428991 0.3549414841525 no 1183 0.3812854260291 408 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_592 k241-0073 46.5 µM 0.301292589289765 0.355263732904523 no 1184 0.381595695713094 425 4230158
SGTC_1065 prochlorperazine maleate 2.48 µM 0.300812852542559 0.355453714062142 no 1185 0.381778603585723 444 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_217 ketoconazole 989 nM 0.300154573659902 0.35571445837347 no 1186 0.382029626667659 403 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2553 4-methylesculetin 85.09 µM 0.299708689744963 0.355891111390418 no 1187 0.382199684846188 395 5319502
SGTC_1277 0873-0036 22 µM 0.299516497184619 0.355967264961226 no 1188 0.382272993260875 396 5965735
SGTC_232 clozapine 119 µM 0.299317690081618 0.356046045497645 no 1189 0.382348829114992 424 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1522 st012842 45.6 µM 0.29919608679341 0.35609423580103 no 1190 0.382395217454964 435 3491067 YOR116C RPO31
SGTC_3233 9132340 49.47 µM 0.298678232694847 0.356299482513973 no 1191 0.382592783569104 441 17682950
SGTC_820 1582-0060 59.9 µM 0.297474474104677 0.356776741959162 no 1192 0.383052146572613 397 3848840
SGTC_91 0417-1751 58.384 µM 0.297092072717226 0.356928401291107 no 1193 0.383198108176254 435 6795624
SGTC_1060 3448-7350 82 µM 0.296999385456245 0.356965164208018 no 1194 0.383233489157577 391 570178
SGTC_1944 st076371 56.9 µM 0.296688254395326 0.35708857906885 no 1195 0.383352262569624 432 24208455
SGTC_2007 4011539 71.82 µM 0.294101095030431 0.358115393226728 no 1196 0.384340327078306 406 45595301
SGTC_1485 3909-9022 254 µM 0.293944396849449 0.358177618017825 no 1197 0.384400196047017 419 714516
SGTC_1818 st052136 56.3 µM 0.293549600849879 0.35833440806546 no 1198 0.384551046200928 426 674169
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.292548160510496 0.358732229118912 no 1199 0.384933771381504 425 165506
SGTC_1487 3970-0795 2.82 µM 0.290710519036516 0.359462628649454 no 1200 0.385636362938468 399 3765103
SGTC_1427 4048-4900 550 nM 0.290497368198293 0.359547382108137 no 1201 0.38571788194604 428 24132586
SGTC_2957 9076800 11.52 µM 0.289370886482206 0.359995410656901 no 1202 0.386148785825735 397 16459615
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.288944732863332 0.36016495227399 no 1203 0.386311835552974 425 97141
SGTC_218 alverine citrate 93.75 µM 0.288700827160664 0.360262000476451 no 1204 0.38640516482985 434 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1677 st019204 53.9 µM 0.288700484849417 0.360262136685792 no 1205 0.386405295818128 386 3945625
SGTC_1085 doxorubicin 7.67 µM 0.287550478320071 0.360719836724991 no 1206 0.38684542847252 432 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1384 3089-0840 101 µM 0.285421390354027 0.361567735371137 no 1207 0.387660660835197 394 1069836
SGTC_760 0568-0725 82.9 µM 0.284626091510013 0.361884633894022 no 1208 0.387965309783511 444 3916171
SGTC_2140 5586273 200 µM 0.28423496429443 0.362040519048338 no 1209 0.38811516115782 426 854421
SGTC_1213 1315-0166 115 µM 0.283914613130362 0.362168213204888 no 1210 0.388237908731716 389 768401
SGTC_3009 9080819 71.4286 µM 0.281766966621456 0.363024675270401 no 1211 0.389061100930942 410 17027216
SGTC_2570 licareol 100 µM 0.281529127594032 0.363119565567867 no 1212 0.389152295262656 413 443158
SGTC_1509 1326-1131 80 µM 0.281332064254537 0.363198194012938 no 1213 0.389227859647519 421 768313
SGTC_83 0170-0301 39.027 µM 0.281153182922615 0.363269572813318 no 1214 0.389296455727827 416 3089716
SGTC_711 k292-0785 179 µM 0.280328926469406 0.363598536178723 no 1215 0.389612579993451 429 4146315
SGTC_1066 ketoconazole 628 nM 0.279655873320348 0.363867228445964 no 1216 0.389870767961316 442 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3014 9081533 49.47 µM 0.279587621096098 0.363894479433319 no 1217 0.389896952715215 445 21367265
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.278307982912088 0.364405526409177 no 1218 0.390387974312901 404 5355888
SGTC_2116 5511452 16.8835 µM 0.275697972199553 0.365448628689898 no 1219 0.391390026621703 442 870744
SGTC_850 0388-0143 75.9 µM 0.271773658199528 0.367018870682731 no 1220 0.392898030413194 403 67273
SGTC_944 3370-0224 231 µM 0.271708761654885 0.367044856632183 no 1221 0.392922981919793 389 4580514
SGTC_3072 9116419 49.47 µM 0.271037141911333 0.367313823139052 no 1222 0.393181232959113 404 17170162
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.270961199751622 0.367344240129306 no 1223 0.39321043717812 449 7104
SGTC_1437 4092-1038 11.6 µM 0.270821000097305 0.367400396256592 no 1224 0.393264353755084 441 3977136
SGTC_501 nsc-95397 161 µM 0.270563978731486 0.367503351981201 no 1225 0.393363201770159 439 262093
SGTC_3329 9141233 27.5565 µM 0.269485957453162 0.367935281471054 no 1226 0.393777873489801 441 4909101 YNL103W MET4
SGTC_2606 farnesol 9.78 µM 0.269458752757753 0.367946183706775 no 1227 0.39378833960982 435 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2307 7538926 6.34 µM 0.264182472363098 0.370062645329017 no 1228 0.395819658229502 418 96582
SGTC_2696 st077691 74.316 µM 0.264040674680503 0.37011957895296 no 1229 0.395874288343852 456 757133
SGTC_700 3453-2283 142 µM 0.263705238856885 0.370254272150539 no 1230 0.396003529184579 407 565664
SGTC_2012 4023501 200 µM 0.262554128908976 0.370716617620225 no 1231 0.396447129837841 442 3477460
SGTC_861 0443-0273 110 µM 0.261818320960869 0.371012254149069 no 1232 0.396730756777564 426 6149169
SGTC_1915 st067105 30.6 µM 0.26174271860503 0.371042634351487 no 1233 0.396759901807275 446 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_337 1315-0038 354 µM 0.261556605862637 0.371117425693795 no 1234 0.396831651518117 453 1626437
SGTC_277 nystatin 15.5 µM 0.261157696637403 0.371277747913384 no 1235 0.396985449750753 443 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1394 3474-0001 65.7 µM 0.260289613117649 0.371626709155768 no 1236 0.397320192042151 422 5017666 YIL048W NEO1
SGTC_1307 1187-1599 12.2 µM 0.260009009252185 0.371739531796893 no 1237 0.397428412083573 423 1538471
SGTC_2208 7283366 200 µM 0.258791000127201 0.372229385370437 no 1238 0.397898251123563 432 898663
SGTC_1260 0700-1617 7.75 µM 0.257977816755517 0.372556543085765 no 1239 0.39821201377827 428 2853078
SGTC_2733 amorolfine 100 µM 0.25790945068297 0.372584052131978 no 1240 0.398238395481059 452 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2862 9027634 71.43 µM 0.256520938080981 0.373142900397203 no 1241 0.398774307469194 416 5012562
SGTC_1753 st043925 64 µM 0.256219905224048 0.37326409529763 no 1242 0.398890519687143 432 670181
SGTC_1770 st043884 66.3 µM 0.256137355848664 0.373297331613015 no 1243 0.398922389024144 461 670149
SGTC_1870 st057514 26.5 µM 0.25541479278164 0.373588292671911 no 1244 0.399201373308718 424 5393161
SGTC_3258 9138477 49.47 µM 0.255297892281974 0.37363537283967 no 1245 0.399246513868766 434 4970355
SGTC_1361 1608-0041 5.61 µM 0.254632817396217 0.373903259033342 no 1246 0.399503354923104 441 X1361
SGTC_654 1124-0271 80.9 µM 0.252770714808249 0.3746536209216 no 1247 0.400222699574017 439 5403748
SGTC_1626 st003712 1.76 µM 0.251531884914891 0.375153089067124 no 1248 0.400701456901876 444 24207035
SGTC_856 0433-0016 11.3 µM 0.251443371443853 0.375188783718651 no 1249 0.400735669474889 435 3911780
SGTC_2137 5261020 140 µM 0.251307569785978 0.375243550261082 no 1250 0.40078816154306 425 763655
SGTC_1622 st003707 19.4 µM 0.250425944363386 0.375599156196451 no 1251 0.401128983985973 435 10140899
SGTC_2333 9017922 200 µM 0.249098310412753 0.376134860215578 no 1252 0.401642368184697 427 3163164
SGTC_2313 7726885 200 µM 0.248126062098942 0.376527316638306 no 1253 0.402018435688619 409 726423
SGTC_722 3534-0461 190 µM 0.24539108245484 0.377631998256892 no 1254 0.403076816570798 410 658262
SGTC_2925 9010536 32.5 µM 0.244453658451577 0.378010862779176 no 1255 0.403439744270472 419 2994177
SGTC_2512 diallyl trisulfide 49.23 µM 0.243903833721021 0.378233131773424 no 1256 0.403652649978132 467 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1772 st048439 82.2 µM 0.242024142257442 0.378993309073903 no 1257 0.404380728211453 428 2927068 YDL195W SEC31
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.241883458259337 0.379050222804324 no 1258 0.404435233998062 418 688801
SGTC_2100 5377183 190 µM 0.241599460055618 0.379165122304241 no 1259 0.404545270253932 438 2844202
SGTC_1857 st056007 79.3 µM 0.241344529003872 0.379268270959576 no 1260 0.404644050754782 418 619834
SGTC_607 4491-0986 66.8 µM 0.239370617495726 0.38006723348094 no 1261 0.405409105828181 428 698981 YDR232W HEM1
SGTC_1678 st019265 80.2 µM 0.239044017706935 0.380199477824248 no 1262 0.4055357253788 440 5367020
SGTC_2259 7964009 200 µM 0.238893924328886 0.380260257210415 no 1263 0.405593918432891 406 313134
SGTC_3031 9088762 49.47 µM 0.236000903678166 0.381432344106929 no 1264 0.406715984473008 424 205253
SGTC_2762 leflunomide 42.06 µM 0.235412731234234 0.381670771481978 no 1265 0.406944202807504 426 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_662 k832-1615 104 µM 0.234349017846772 0.382102082795144 no 1266 0.407357017237758 471 5878478
SGTC_629 3448-6466 76.7 µM 0.233426909901759 0.382476094808716 no 1267 0.407714959586789 454 573744
SGTC_690 glyoxal 20.3 µM 0.233291749011351 0.382530926026037 no 1268 0.407767432601261 436 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2249 haloperidol 116.36 µM 0.233171449862498 0.382579730206676 no 1269 0.407814137288299 460 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1745 st081495 74 µM 0.232172337789168 0.382985132133266 no 1270 0.40820208100934 443 13842402 YBL026W LSM2
SGTC_2331 7980721 200 µM 0.231744154696621 0.383158911926034 no 1271 0.408368367148779 428 2981221
SGTC_1040 k898-0338 155 µM 0.230233144599929 0.383772349014945 no 1272 0.408955303945874 451 20969351
SGTC_2026 5148700 152 µM 0.229825872178768 0.383937742637965 no 1273 0.409113539848461 421 79838
SGTC_33 0986-0033 35.816 µM 0.229395790269441 0.38411242216143 no 1274 0.409280653907901 438 2848082
SGTC_109 0132-0036 33.701 µM 0.229231563248406 0.384179129849803 no 1275 0.409344470857947 466 67274 A color developer.
SGTC_2790 5423970 71.43 µM 0.228801627954581 0.384353782334236 no 1276 0.409511550713794 423 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2111 5486399 200 µM 0.228773740084479 0.384365112026591 no 1277 0.409522388962186 429 689674
SGTC_1306 1185-0270 9.02 µM 0.228528289691772 0.384464832666013 no 1278 0.409617782962011 450 1548076
SGTC_2051 5263410 176 µM 0.228387074322445 0.384522208567374 no 1279 0.409672668570673 443 227584
SGTC_3320 9137005 35.139 µM 0.228088246954433 0.384643630671124 no 1280 0.409788818434932 457 4908713
SGTC_2752 diclazuril 33.15 µM 0.227497573381015 0.384883671514924 no 1281 0.410018427967933 435 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1499 4480-0877 67.3 µM 0.227398531914731 0.384923924797569 no 1282 0.41005693087597 454 2861909
SGTC_948 3448-0295 75.3 µM 0.226533585864631 0.38527551626294 no 1283 0.410393220167575 418 678569
SGTC_248 streptozotocin 5.23457 mM 0.226224085833476 0.385401347696493 no 1284 0.410513569181059 446 5300 DNA alkylating agent.
SGTC_2009 4012297 12.05 µM 0.22621540219592 0.385404878321122 no 1285 0.410516945933038 409 45595307
SGTC_460 trequinsin 123 µM 0.225811411695594 0.385569144727577 no 1286 0.41067405052807 453 5537 A vasodilator.
SGTC_1297 1068-0111 14.1 µM 0.222578026274213 0.386884607496122 no 1287 0.411931969974875 455 767057
SGTC_1302 1159-0335 255 µM 0.22217558501022 0.387048427046545 no 1288 0.412088599749436 434 649284
SGTC_879 0831-1030 162 µM 0.220763127510046 0.38762354741116 no 1289 0.41263843760355 458 1549252
SGTC_3 0833-0587 95.581 µM 0.219556902941142 0.388114889773451 no 1290 0.413108129416554 426 5382644
SGTC_223 busulfan 5 mM 0.217711273721193 0.388867033145645 no 1291 0.413827039605111 453 2478 A DNA alkylator.
SGTC_2435 5706476 10.6 µM 0.217046507882122 0.389138045273757 no 1292 0.414086050341769 449 5725375
SGTC_330 1488-0319 80.1 µM 0.216320094365589 0.389434251639582 no 1293 0.414369123409456 443 6846614
SGTC_6 0844-0013 19.835 µM 0.216316403710494 0.389435756725564 no 1294 0.41437056171922 455 1584900
SGTC_671 0560-0003 407 µM 0.216165368731487 0.389497351719835 no 1295 0.414429423551071 461 3238678
SGTC_2806 7952793 58.44 µM 0.216083530012328 0.389530728296794 no 1296 0.414461318799566 428 2972490
SGTC_1303 1160-0052 261 µM 0.215214761350062 0.389885091513173 no 1297 0.414799941340406 465 3562476
SGTC_1714 st033236 13.627 µM 0.214728369650422 0.390083526469006 no 1298 0.41498955134135 437 2916566
SGTC_544 k015-0020 52.4 µM 0.214319545265815 0.390250338170684 no 1299 0.415148938608346 442 3008304
SGTC_737 1950-0117 57.9 µM 0.213842509937923 0.390445007377236 no 1300 0.415334936746803 436 5393513
SGTC_207 4185-0010 4.486 µM 0.213384237615702 0.39063204562171 no 1301 0.415513636978572 446 3761753
SGTC_2868 9035608 32.47 µM 0.21286973424298 0.390842064038215 no 1302 0.415714284954842 465 6462614
SGTC_2269 7935389 174.42 µM 0.21168502467583 0.391325779185251 no 1303 0.416176385963458 446 97605
SGTC_1792 st045773 43.6 µM 0.209326065204966 0.392289438798571 no 1304 0.417096852688837 446 2919270
SGTC_405 ebelactone b 50 µM 0.207703950808305 0.392952473365004 no 1305 0.417730066328098 442 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_758 0868-0029 16 µM 0.207659485180054 0.392970652945732 no 1306 0.417747427081561 434 762687
SGTC_2651 TUB2.036 5 µM 0.207122330070234 0.393190284933058 no 1307 0.417957161668348 439 15992207 YFL037W TUB2
SGTC_3063 1327-0034 4 µM 0.206423352454681 0.393476133806531 no 1308 0.418230115498772 473 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2544 sphondin 68.51 µM 0.205827147577715 0.393719998865108 no 1309 0.418462967253334 471 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_14 0354-0009 295 µM 0.20524229353262 0.393959261612074 no 1310 0.418691413631288 492 1713507
SGTC_2965 9082772 38.63 µM 0.204332991588496 0.394331334887222 no 1311 0.419046645119093 424 16459634
SGTC_2016 5121758 140 µM 0.203799453041952 0.394549696102548 no 1312 0.419255110140516 468 2795203
SGTC_2785 7756463 72.73 µM 0.203687337246035 0.394595585927803 no 1313 0.419298919085069 473 2201551
SGTC_1902 st060212 70.5 µM 0.201576355382779 0.395459898806055 no 1314 0.420123965720426 435 688944
SGTC_633 0437-0093 97.7 µM 0.201199436945938 0.395614277196105 no 1315 0.420271315871565 445 2831118
SGTC_2877 9040724 71.43 µM 0.200776715095736 0.395787435250011 no 1316 0.420436585417795 437 6463895
SGTC_1983 st071813 46.9 µM 0.199697802717647 0.396229479477783 no 1317 0.4208584661697 447 11838595
SGTC_1331 1472-0049 76.2 µM 0.198998747461631 0.396515962656359 no 1318 0.421131862190329 481 24051409
SGTC_3037 9091026 49.47 µM 0.198546425015841 0.396701360866324 no 1319 0.421308782869036 449 25236398 YIL048W NEO1
SGTC_2756 carbadox 75.1 µM 0.198446209190673 0.396742440553934 no 1320 0.421347983278193 447 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2291 7917025 104.35 µM 0.197525953456355 0.397119718113975 no 1321 0.421707986792078 453 2964612
SGTC_1754 st042065 16.137 µM 0.197160411672156 0.397269606146436 no 1322 0.421851004705186 451 1126236 YIL048W NEO1
SGTC_1484 3473-2379 286 µM 0.194009639556325 0.398562186576184 no 1323 0.423084167018879 485 671917
SGTC_387 norethindrone acetate 66.7 µM 0.191967537470968 0.399400539205076 no 1324 0.423883816907111 451 541197
SGTC_789 1309-1135 70.6 µM 0.191961748921713 0.399402916263638 no 1325 0.423886084044456 430 3092424
SGTC_2969 9091408 28.7 µM 0.191910444406262 0.399423984544454 no 1326 0.423906178029182 429 4286311
SGTC_2934 9036370 36.88 µM 0.19185749529663 0.39944572848762 no 1327 0.423926916344988 453 6462800
SGTC_120 rhodamine 6G 52.259 µM 0.190765970095498 0.399894040775165 no 1328 0.424354475474598 480 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_262 fenpropimorph 62.5 µM 0.189871250915452 0.400261619164643 no 1329 0.424705010542177 473 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3324 9138759 60.749 µM 0.188222571296472 0.400939179108402 no 1330 0.425351089683396 452 45595710
SGTC_1710 st031758 61.5 µM 0.187917791063751 0.401064467732134 no 1331 0.425470547968878 476 5394341
SGTC_551 k048-0028 34.9 µM 0.186361155730756 0.401704525604134 no 1332 0.426080776001457 462 6836383
SGTC_538 2922-0838 53.3 µM 0.186125895799701 0.401801282853312 no 1333 0.426173017408647 437 777039
SGTC_1442 4112-3290 3 µM 0.185835359771226 0.401920782255533 no 1334 0.426286937204693 472 704353
SGTC_203 k066-0004 30.888 µM 0.184617667425753 0.40242172685404 no 1335 0.426764463774957 472 6795412
SGTC_992 3909-8734 162 µM 0.183942024275902 0.40269974785356 no 1336 0.427029468318015 452 4288319
SGTC_233 rapamycin 362 pM 0.183832749662198 0.402744717988283 no 1337 0.427072331716792 457 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.182977823590855 0.403096592845002 no 1338 0.427407709526566 449 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_140 0062-0056 502.533 µM 0.18269089285788 0.403214706872633 no 1339 0.427520280973094 435 3758964
SGTC_3188 9110789 49.47 µM 0.182577103310526 0.403261550385798 no 1340 0.427564925625987 451 849217
SGTC_377 3970-0964 33.1 µM 0.182349630978777 0.403355197621823 no 1341 0.427654175823781 453 16481235
SGTC_2266 7929956 200 µM 0.18215816945197 0.403434023999707 no 1342 0.427729299825709 479 2967153
SGTC_1182 1222-0449 220 µM 0.180592007365666 0.404078973600528 no 1343 0.428343914964411 484 658318
SGTC_713 1488-1073 324 µM 0.180478441327598 0.404125750551967 no 1344 0.42838848890888 480 3312542
SGTC_1730 st033808 45.1 µM 0.179041613589403 0.404717686689261 no 1345 0.428952513331297 489 1045166
SGTC_148 3253-0744 288.01 µM 0.178136065393866 0.405090861438523 no 1346 0.429308059442252 468 6893655
SGTC_639 0833-0042 114 µM 0.17523691297115 0.406286175769147 no 1347 0.43044674035233 478 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2142 5622915 118.518 µM 0.172572241872048 0.407385585062798 no 1348 0.431493836138374 470 5322196
SGTC_2232 chlorophetanol 41.5365 µM 0.170010773376443 0.408443102549512 no 1349 0.432500832032372 476 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2145 5634607 200 µM 0.168019427045681 0.409265703038545 no 1350 0.43328399788568 455 308662
SGTC_832 4083-0019 164 µM 0.167401248076722 0.409521146578027 no 1351 0.433527171604934 471 1990758
SGTC_2846 9008642 19.48 µM 0.167027266034741 0.409675701868581 no 1352 0.433674297542393 482 2992898
SGTC_1950 st077106 7.18 µM 0.166848234663122 0.409749695005048 no 1353 0.433744732409375 423 13831864
SGTC_398 bronopol 33.3 µM 0.166096447821252 0.410060441342516 no 1354 0.434040524778493 481 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2387 9077560 195.08 µM 0.166071204009166 0.410070876693961 no 1355 0.434050457659901 437 5303272
SGTC_3242 9133940 49.47 µM 0.165880917672431 0.410149539794226 no 1356 0.434125332461907 459 17248444
SGTC_355 1311-2252 105 µM 0.165823674030842 0.410173204640797 no 1357 0.434147857433604 474 5338538
SGTC_274 sirtinol 40.1 µM 0.16526539207007 0.410404018714404 no 1358 0.434367548672003 428 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_714 4296-0578 26.1 µM 0.164922042003282 0.410545987542699 no 1359 0.434502671475961 469 1589775
SGTC_1752 st044819 83.042 µM 0.164749075639317 0.410617510338855 no 1360 0.434570743970435 460 441209 YML126C ERG13
SGTC_1658 st012944 20 µM 0.16423719122219 0.410829195516675 no 1361 0.434772212122062 480 24207260
SGTC_301 4119-0100 24.5 µM 0.164053120758988 0.410905322546795 no 1362 0.43484466296372 478 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_450 aminopyrene 156 nM 0.163477075761007 0.411143582304482 no 1363 0.435071410614553 478 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2338 7999974 200 µM 0.163067414128032 0.411313043673557 no 1364 0.43523267805063 485 315925
SGTC_2731 amoxapine 43.43 µM 0.162915239013616 0.411375996922502 no 1365 0.435292586065829 495 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_101 0490-5701 117.494 µM 0.162856594394121 0.411400258195801 no 1366 0.435315673566796 493 4661669
SGTC_84 0443-0269 128.823 µM 0.158284486537924 0.413292774565114 no 1367 0.437116315994058 497 6150058
SGTC_2694 st077685 81.9 µM 0.158002232578811 0.413409673476473 no 1368 0.437227519736063 436 2838096
SGTC_1736 st036774 51 µM 0.157628271353333 0.413564565888821 no 1369 0.437374862374921 488 1272247
SGTC_1112 tnp00069 1.16933 µM 0.157604058840913 0.413574595024692 no 1370 0.437384402528471 492 145826
SGTC_1503 4585-0012 61.3 µM 0.15534117035306 0.414512160725127 no 1371 0.438276180140182 465 2922052
SGTC_1233 0325-0408 14.2 µM 0.155106664118013 0.414609349898983 no 1372 0.43836861428181 477 12874
SGTC_2200 6600604 21.907 µM 0.154420500039609 0.414893754943886 no 1373 0.438639095414191 484 2904777
SGTC_2053 5265679 138 µM 0.154070456215301 0.415038860218757 no 1374 0.438777091315907 475 764595
SGTC_3191 9110352 49.47 µM 0.15360622506839 0.415231317965426 no 1375 0.438960114151576 475 17122424
SGTC_1072 oxiconazole 14.9 nM 0.153497858373825 0.415276246812278 no 1376 0.439002839532627 479 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1690 st023502 41.2 µM 0.153378596445321 0.415325694105202 no 1377 0.439049861363266 493 24207482
SGTC_2744 captopril 92.04 µM 0.15289007788072 0.415528253205807 no 1378 0.439242480310096 476 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2681 menadione 3.18 µM 0.152877107901849 0.415533631377712 no 1379 0.439247594464862 490 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1866 st057638 64 µM 0.15207834679695 0.415864878606125 no 1380 0.439562571149984 478 688802
SGTC_3289 9119912 71.43 µM 0.151644723714713 0.41604472769264 no 1381 0.43973357843856 475 17014829
SGTC_3201 9113999 49.47 µM 0.151036351264034 0.41629708528809 no 1382 0.439973520324079 462 16649224
SGTC_64 000l-0018 272.079 µM 0.149923450757152 0.416758814254286 no 1383 0.440412504897196 467 6811119
SGTC_1164 k060-0068 93.7 µM 0.148886656135791 0.417189071171114 no 1384 0.440821535356486 490 5963676
SGTC_2221 6807166 181.081 µM 0.147969093008955 0.417569931247967 no 1385 0.441183579951964 467 674925
SGTC_2302 7771753 200 µM 0.147832167846439 0.417626772482461 no 1386 0.441237610991376 476 2203047
SGTC_386 1509-0011 3.07 µM 0.147575643385428 0.417733267161696 no 1387 0.441338839180516 480 3107280
SGTC_526 4469-0568 170 µM 0.147466979382025 0.417778380227807 no 1388 0.441381720692695 460 2901964
SGTC_1779 st039427 55 µM 0.14695825788747 0.417989595979383 no 1389 0.441582483948796 481 1124498
SGTC_2982 9019404 25.97 µM 0.14552564569943 0.418584528237113 no 1390 0.44214793446694 413 22333232
SGTC_570 0987-0065 62.6 µM 0.145145272819877 0.418742520058948 no 1391 0.442298087094917 494 3104428
SGTC_2451 5856223 45.7 µM 0.144776316118934 0.418895782576124 no 1392 0.442443741094143 483 2179896
SGTC_1457 k015-0032 57.3 µM 0.143627419239365 0.419373106557022 no 1393 0.442897343859771 475 4302660
SGTC_423 5-fluorouracil 457 µM 0.143347522086338 0.419489411432628 no 1394 0.443007863070827 470 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1932 st074806 40.9 µM 0.141739313669678 0.420157801758092 no 1395 0.443642960298693 494 17251235
SGTC_1416 3966-0321 25.3 µM 0.139106748493259 0.421252423075954 no 1396 0.4446828977756 468 582530 YLR208W SEC13
SGTC_115 0527-0192 112.043 µM 0.138582785271902 0.421470360054803 no 1397 0.444889923698026 493 4233931
SGTC_1698 5-fluorocytosine 1.055 µM 0.136070050749539 0.42251583869724 no 1398 0.445882951663622 496 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1160 4092-0570 10.5 µM 0.134334914602554 0.423238099586583 no 1399 0.44656887279218 483 4994975
SGTC_271 rotenone 740 µM 0.133718682826753 0.423494672002306 no 1400 0.446812515541938 494 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_866 0495-0101 262 µM 0.131848099896323 0.424273700576537 no 1401 0.447552220201501 491 635694
SGTC_1646 st011709 75.6 µM 0.131663255341175 0.424350697611016 no 1402 0.447625325212588 499 5757843
SGTC_61 0978-8327 98.565 µM 0.131078620038403 0.424594246550826 no 1403 0.447856556980062 471 6150059 YHR072W ERG7
SGTC_1116 jasmonic acid 1.58368 µM 0.130286209558512 0.42492439697196 no 1404 0.448169995124615 497 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2726 cimetidine 79.27 µM 0.129431222468738 0.425280678416473 no 1405 0.448508221750954 500 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_508 roscovitine 141 µM 0.128587514247314 0.425632319675776 no 1406 0.448842023234181 502 160355 A CDKinase inhibitor.
SGTC_96 0929-0093 37.281 µM 0.128152943351527 0.425813463515032 no 1407 0.449013969341642 478 6991579
SGTC_2364 9055074 200 µM 0.124999699310306 0.427128308863101 no 1408 0.450261894194202 470 6470630
SGTC_2180 6301957 200 µM 0.124690269847249 0.427257379192596 no 1409 0.450384380408562 480 845462
SGTC_224 benfluorex 43.875 µM 0.123845105612336 0.427609956777469 no 1410 0.450718958790469 503 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2341 7987486 176.74 µM 0.12374366297853 0.427652279543406 no 1411 0.450759119630655 502 1258686
SGTC_1191 1487-1166 10.6 µM 0.123664885216307 0.427685146898333 no 1412 0.450790307862667 506 3955771
SGTC_642 0335-0876 158 µM 0.123581417561014 0.427719971499935 no 1413 0.450823353161754 502 6812350
SGTC_451 chloral hydrate 100 µM 0.121533471593235 0.428574596822197 no 1414 0.451634252344364 499 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_375 3970-0961 9.27 µM 0.121027936122901 0.428785612802125 no 1415 0.451834454003963 475 2898222
SGTC_392 N-ethylmaleimide 8.33 µM 0.120031117321158 0.429201755356818 no 1416 0.452229249047275 478 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1844 rapamycin 4 nM 0.118868023563513 0.429687412274534 no 1417 0.452689957803277 493 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_640 3381-0960 37.1 µM 0.118816562841177 0.429708902478007 no 1418 0.452710343195257 488 1745025
SGTC_2168 5727979 200 µM 0.118812436146464 0.429710625811247 no 1419 0.452711977928766 500 695210
SGTC_3045 9092950 49.47 µM 0.118686026500598 0.42976341591003 no 1420 0.452762053764307 480 44120432
SGTC_1681 tripelennamine 100 µM 0.11855732967534 0.4298171624509 no 1421 0.452813036413421 464 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_107 0358-0022 2.6945 µM 0.118050748207387 0.430028734310375 no 1422 0.453013723856679 509 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2968 9090663 33.37 µM 0.117233620693987 0.430370046886394 no 1423 0.453337462571727 501 25236811
SGTC_1122 capsaicin 818.572 nM 0.116183916557312 0.430808582582765 no 1424 0.453753391575639 506 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2589 lobaric acid 100 µM 0.116085147316697 0.430849849884217 no 1425 0.453792529975478 475 73157 A novel microtubule depolymerizer.
SGTC_2896 9052656 71.43 µM 0.114762406425851 0.43140258387716 no 1426 0.454316723724469 498 6469436
SGTC_496 calpeptin 138 µM 0.114322450034634 0.431586458368693 no 1427 0.454491093307325 463 73364 A calpain inhibitor.
SGTC_1695 st026914 34.495 µM 0.11322391121037 0.432045644118768 no 1428 0.454926519577641 472 3289191
SGTC_159 3970-0959 50 µM 0.112347671459053 0.432411975419096 no 1429 0.455273872336624 483 6615653
SGTC_1197 1601-0112 267 µM 0.110239459447128 0.433293597324408 no 1430 0.456109734425958 512 7350313
SGTC_1319 1306-0155 43.7 µM 0.109710339223425 0.433514919581446 no 1431 0.45631955020185 492 3122360
SGTC_4 0960-0234 25.671 µM 0.109159443470086 0.433745372337009 no 1432 0.456538013723677 459 6821112
SGTC_2776 terbinafine 19.92 µM 0.108206548829938 0.434144043891067 no 1433 0.456915925122744 498 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2560 caryophyllene 100 µM 0.107856376808811 0.434290565529747 no 1434 0.457054810724586 511 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1424 4048-1941 275 µM 0.107756412067006 0.434332395194069 no 1435 0.457094459810697 510 X1424
SGTC_306 1672-3436 11.6 µM 0.106647887430396 0.434796300053581 no 1436 0.45753416325951 507 6797378
SGTC_1771 st048882 4.1505 µM 0.106471984897334 0.434869921518264 no 1437 0.457603940926942 494 4580403
SGTC_309 k408-0051 1.48 µM 0.106411766162198 0.434895125719123 no 1438 0.457627829017912 515 3640463
SGTC_2013 4024628 200 µM 0.106409049176426 0.434896262903931 no 1439 0.45762890681904 485 5230760
SGTC_3179 9107801 49.47 µM 0.105057256557506 0.43546211753551 no 1440 0.458165187937416 468 4818259
SGTC_536 3852-0578 10.6 µM 0.104970835458018 0.435498297546779 no 1441 0.458199475385585 464 2869208
SGTC_1922 5578187 25 µM 0.102920169652476 0.4363569622125 no 1442 0.459013164819442 511 1350412
SGTC_1712 st032288 53.4 µM 0.100691400943272 0.437290543096997 no 1443 0.459897718866724 497 2883011
SGTC_1032 k061-1018 98.7 µM 0.0980337820107927 0.438404215800579 no 1444 0.460952734195926 476 4005393
SGTC_3341 9147222 25.867 µM 0.0976772872032388 0.438553641921941 no 1445 0.461094275741658 498 1939759
SGTC_976 1348-1067 47.6 µM 0.0961778724327945 0.439182222841023 no 1446 0.461689652286621 489 5310671 YGL099W LSG1
SGTC_1546 5-methoxyflavanone 78.7 µM 0.096145537434444 0.439195779933644 no 1447 0.461702492579577 497 147795
SGTC_557 1315-0110 16.2 µM 0.095581089572994 0.439432447426565 no 1448 0.461926642380659 503 6833801
SGTC_2257 7960413 200 µM 0.0947720734313515 0.439771697750735 no 1449 0.462247934589956 499 2974689 YIL048W NEO1
SGTC_2924 9010168 62.78 µM 0.0944312375075632 0.439914636088407 no 1450 0.462383301362065 490 2993929
SGTC_2063 5246145 200 µM 0.0940981545006795 0.440054330607509 no 1451 0.462515593186638 506 711240
SGTC_515 4092-1064 102 µM 0.0940675607034064 0.440067161975184 no 1452 0.46252774444775 503 717353
SGTC_1962 st076595 64.5 µM 0.0935943382007153 0.440265644592206 no 1453 0.462715703666785 493 279619
SGTC_2849 9019321 12.99 µM 0.0933636873297974 0.44036239139659 no 1454 0.46280731889343 512 16489627
SGTC_1803 st050068 52.4 µM 0.0928947779913491 0.440559086992392 no 1455 0.462993577184535 502 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2309 7664088 163.95 µM 0.092474103379535 0.440735561824997 no 1456 0.463160682776196 507 704922
SGTC_3082 9117008 49.47 µM 0.0911580646903513 0.441287721642238 no 1457 0.463683497847365 511 41448529
SGTC_695 3505-6186 243 µM 0.0898829991459667 0.441822799561694 no 1458 0.464190095589111 497 1819379
SGTC_111 0083-0039 52.457 µM 0.089810736233374 0.441853127692354 no 1459 0.46421880819537 517 759313
SGTC_1629 st005085 44.9 µM 0.0897037691282957 0.441898021503535 no 1460 0.464261310344488 516 24207091
SGTC_3019 9081971 49.47 µM 0.0896595186030249 0.441916593550261 no 1461 0.464278892901118 492 16451803
SGTC_1814 st052110 31.539 µM 0.0886159178417702 0.442354632104634 no 1462 0.464693578623588 502 674163
SGTC_3112 9123419 49.47 µM 0.0879980665500919 0.442614000821319 no 1463 0.464939106425949 508 17015854
SGTC_379 3970-0972 5.9 µM 0.0875393106237204 0.442806598575357 no 1464 0.465121419993742 501 2898042 YBL034C STU1
SGTC_2502 avocadyne acetate 18.59 µM 0.087368859939434 0.442878161683486 no 1465 0.465189160435602 517 3952079
SGTC_2125 5246583 200 µM 0.0864283958295629 0.443273045610271 no 1466 0.465562937386592 507 835267
SGTC_1016 4226-1401 38 µM 0.0846255388718275 0.444030189955604 no 1467 0.466279547405283 516 2901613
SGTC_1679 SEC14.276 6.7 µM 0.083329127953932 0.444574769031146 no 1468 0.466794920036061 512 1005053 YMR079W SEC14
SGTC_1172 0370-0043 85 µM 0.0819547425172669 0.445152216858989 no 1469 0.467341351285939 503 376585
SGTC_2110 5483698 200 µM 0.0811613625248646 0.445485608408493 no 1470 0.467656813173007 507 2848765 YHR062C RPP1
SGTC_3050 9093513 49.47 µM 0.0808473650083105 0.445617566081679 no 1471 0.467781669748946 510 25236664
SGTC_2093 5331342 194.4 µM 0.0807145700032209 0.445673375087894 no 1472 0.46783447471856 510 33839
SGTC_1896 st058441 89 µM 0.0805348582967963 0.44574890322496 no 1473 0.467905936674914 475 688759
SGTC_1271 0832-2808 169 µM 0.0803635980124712 0.445820881282165 no 1474 0.467974038904753 509 3663794
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0790009860952055 0.44639362949293 no 1475 0.468515919362996 504 390807
SGTC_2691 st077356 60.2 µM 0.0784297115422991 0.446633787319719 no 1476 0.46874311996182 508 2839272
SGTC_2359 9039622 200 µM 0.0780632217037567 0.446787866113928 no 1477 0.468888881356492 514 6463596
SGTC_1811 st050069 61.5 µM 0.0774509441321662 0.447045296316779 no 1478 0.469132407450087 522 3877702
SGTC_2250 alverine citrate 130 µM 0.076316843390167 0.447522184313348 no 1479 0.469583512917737 524 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2517 totarol 10 µM 0.0762704369858857 0.447541699770993 no 1480 0.469601972591937 498 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_814 3342-0569 96 µM 0.0761342081812098 0.447598989309887 no 1481 0.46965616245857 519 4346283
SGTC_1454 4239-0054 42.6 µM 0.0739192987420135 0.448530597868091 no 1482 0.470537299841089 530 1340767
SGTC_2760 etidronate 98.04 µM 0.0738556614978294 0.448557368420024 no 1483 0.470562618222909 522 3305 A chelator and antioxidant.
SGTC_74 000s-0487 160.283 µM 0.0733085864566769 0.448787518469504 no 1484 0.470780279541368 505 677548
SGTC_3124 9127567 49.47 µM 0.0731742165596726 0.448844049438845 no 1485 0.470833741788139 502 17592030
SGTC_2497 7-hydroxyflavone 100 µM 0.073168094980027 0.448846624882928 no 1486 0.470836177416149 505 5281894
SGTC_477 mead ethanolamide 10 µM 0.0729140015279581 0.448953527863576 no 1487 0.470937275996878 501 16061185
SGTC_1604 st002052 72.4 µM 0.0726851856648324 0.449049799150599 no 1488 0.47102831874567 519 6254834 YHR062C RPP1
SGTC_767 0929-0023 86 µM 0.0725172828761491 0.449120443965314 no 1489 0.47109512596638 521 1204563
SGTC_2848 9016370 25.97 µM 0.0715644704389792 0.449521368671482 no 1490 0.471474258014547 526 7894410
SGTC_2383 9036125 200 µM 0.0711741067793957 0.449685640916345 no 1491 0.471629594468941 522 79580
SGTC_1497 4476-2978 41.3 µM 0.0711356943181379 0.44970180605665 no 1492 0.471644880079135 515 1528379
SGTC_212 3807-4682 38.772 µM 0.0710036198898701 0.449757387658336 no 1493 0.471697437254532 491 3125501 YBL034C STU1
SGTC_1 0258-0098 57.368 µM 0.0703056751938556 0.45005112387157 no 1494 0.471975182767801 487 6790032 YDR047W HEM12
SGTC_966 1300-0360 30.2 µM 0.0702426511902261 0.450077649431812 no 1495 0.472000263700436 512 70588
SGTC_216 k038-0035 28.382 µM 0.069991557706484 0.450183331940556 no 1496 0.472100189566828 500 4444231 YPR107C YTH1
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0699766342449182 0.450189613174061 no 1497 0.472106128604762 502 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1479 0549-0158 134 µM 0.0694875127544584 0.450395489619643 no 1498 0.472300786002994 489 5440202
SGTC_249 wiskostatin 11.211 µM 0.0686844108826777 0.450733552679344 no 1499 0.472620413605156 522 2775510 A n-wasp and actin depolymerizer.
SGTC_3308 9128332 17.569 µM 0.0670587115012029 0.451417994582236 no 1500 0.473267481659577 520 17332805 YDL196W YDL196W
SGTC_1356 1502-0781 85.8 µM 0.0668105203141682 0.451522499261721 no 1501 0.473366274062417 505 567702
SGTC_1483 3453-0561 55.9 µM 0.0667955730772645 0.451528793130813 no 1502 0.473372223856455 512 4546991
SGTC_1795 st049545 62.3 µM 0.0666017479546273 0.45161040864547 no 1503 0.473449377085527 515 5291882
SGTC_3154 9100113 49.47 µM 0.0655883193852135 0.45203717445005 no 1504 0.47385279443461 508 25237525
SGTC_1912 st060209 90.8 µM 0.0642857474971411 0.452585782990538 no 1505 0.474371350914808 528 688787
SGTC_1045 1348-1485 165 µM 0.0637771897721059 0.452799998571164 no 1506 0.474573820599649 501 6810614
SGTC_793 0488-0545 106 µM 0.0620358446822506 0.453533594693247 no 1507 0.4752671435162 534 292548
SGTC_1459 k035-0031 35.7 µM 0.0619521830265982 0.453568843796735 no 1508 0.475300455612847 521 3877128 YMR208W ERG12
SGTC_1700 st030840 7.9285 µM 0.0593004659794158 0.454686277854915 no 1509 0.476356394985932 502 5499307
SGTC_1371 2421-0008 32.7 µM 0.0582189447401457 0.455142134590359 no 1510 0.476787115297617 517 2827552
SGTC_842 0271-0008 11.1 µM 0.0568917739800288 0.455701612248925 no 1511 0.477315703557097 516 1221709
SGTC_202 3594-0513 34.79 µM 0.056707133688485 0.45577945557843 no 1512 0.477389245650284 531 708429
SGTC_1662 st014054 52 µM 0.0564549377811647 0.45588578272556 no 1513 0.477489696339531 522 2838777
SGTC_664 1222-0054 14.9 µM 0.0555097614832082 0.456284302169769 no 1514 0.477866176701612 521 6813991
SGTC_169 k015-0017 16.025 µM 0.0553315327608344 0.456359454584412 no 1515 0.477937170563712 527 1840002
SGTC_1349 flufenamic acid 69 µM 0.0544847879397603 0.456716516622134 no 1516 0.478274464026007 514 3371 A non-steroidal anti-inflammatory.
SGTC_825 1988-2224 89.6 µM 0.0528968264764804 0.457386234750611 no 1517 0.478907056481554 509 1180859
SGTC_2381 9035592 200 µM 0.0527707646424079 0.457439406172886 no 1518 0.478957277734087 501 4749657
SGTC_680 0417-1641 114 µM 0.0526896275522003 0.457473629261288 no 1519 0.478989601780541 509 2835990
SGTC_1986 st071812 45 µM 0.0526770261645933 0.457478944471594 no 1520 0.478994622035071 526 11838594
SGTC_1556 plumbagin 1.48 µM 0.0522770276037768 0.457647666066376 no 1521 0.479153978799503 528 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_854 0422-0053 192 µM 0.051920881018547 0.457797897081021 no 1522 0.479295868033846 525 3596728
SGTC_2244 6635614 200 µM 0.0514155497701878 0.458011068041308 no 1523 0.479497197118338 532 836499
SGTC_2715 st079500 56.4 µM 0.0514014054495858 0.458017034912287 no 1524 0.479502832434336 523 28246688
SGTC_1550 gossypolone 36.6 µM 0.0510928974261825 0.458147183321965 no 1525 0.479625747817684 527 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_670 4204-0025 119 µM 0.0502391987006595 0.458507351375159 no 1526 0.479965887465931 529 719039
SGTC_742 0kpi-0133 140 µM 0.0501356956100768 0.458551020748595 no 1527 0.480007127255205 529 2728852
SGTC_352 k048-0007 5.11 µM 0.0491590541496924 0.45896310373294 no 1528 0.480396270922758 530 6811911
SGTC_2580 diallyl disulphide 81.36 µM 0.0485494203279218 0.459220354316451 no 1529 0.480639189561635 529 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1573 oleylamine 1.06 µM 0.0483161751818962 0.45931878259386 no 1530 0.480732131838903 525 5356789 An amine of the fatty acid oleic acid.
SGTC_913 3487-1245 167 µM 0.0453850448174219 0.46055591545742 no 1531 0.481900200605666 530 4016153
SGTC_407 eburnamonine 100 µM 0.0449360418546418 0.460745458738219 no 1532 0.482079144301405 524 3195
SGTC_360 0957-0399 1.01 µM 0.0441089283265862 0.461094641914743 no 1533 0.482408787968732 515 6752301 YPR165W RHO1
SGTC_531 3788-1495 174 µM 0.0426106494111236 0.461727247720593 no 1534 0.483005953099701 519 2896655
SGTC_2069 5228469 200 µM 0.0424657560190532 0.46178843000964 no 1535 0.483063704925328 526 2835210
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0416371574797762 0.462138329100097 no 1536 0.48339397576446 518 16623 A steroid.
SGTC_1686 st019653 115.5 µM 0.0413049514432011 0.462278620707991 no 1537 0.483526392879993 536 97252
SGTC_2618 avocadyne 43.43 µM 0.0404186533574686 0.462652929968351 no 1538 0.483879679585638 520 3015189
SGTC_1512 0259-0544 12.2 µM 0.040112406281779 0.462782274651913 no 1539 0.484001755490161 505 18476
SGTC_3305 9127027 53.8275 µM 0.0400604753783186 0.462804208268358 no 1540 0.484022456284237 514 41905295
SGTC_1145 3546-0597 10.2 µM 0.0391236385124794 0.463199911488732 no 1541 0.484395907293467 526 875334
SGTC_3204 9114183 49.47 µM 0.0386928233367039 0.463381892399067 no 1542 0.484567647636988 530 17027248
SGTC_1578 josamycin 24.2 µM 0.0385826942164378 0.46342841334158 no 1543 0.484611550016697 509 5282165 A P450 substrate.
SGTC_1687 st020778 55.3625 µM 0.0379069575068449 0.463713870191578 no 1544 0.484880932874726 532 4259299
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0378178279549399 0.463751523297132 no 1545 0.484916464943582 529 6708739 YPR165W RHO1
SGTC_994 3910-0338 138 µM 0.0375691969395425 0.463856560095081 no 1546 0.4850155839284 533 3479481
SGTC_768 0384-0033 77.3 µM 0.0369915456409277 0.464100604699769 no 1547 0.485245873364798 520 3965305 YMR134W ERG29
SGTC_1716 st033144 30.6155 µM 0.0360902278366067 0.46448141802715 no 1548 0.485605207154988 536 674617
SGTC_2520 obtusaquinone 4.71 µM 0.0357981189804825 0.464604843141628 no 1549 0.485721666471693 539 5967872
SGTC_2706 st078239 82.5 µM 0.0357749636538179 0.464614627136147 no 1550 0.485730898197196 534 15434492
SGTC_1336 1486-0901 104 µM 0.0354837568258259 0.464737674774333 no 1551 0.485846999197138 536 5006114
SGTC_1298 1079-1278 263 µM 0.0351907405121463 0.464861490403167 no 1552 0.485963822830249 532 2840950
SGTC_2602 kawain 100 µM 0.0349219049806142 0.464975091304718 no 1553 0.486071006808042 528 5369129
SGTC_3137 9097352 49.47 µM 0.0341626300813846 0.46529595086197 no 1554 0.486373733004999 533 44120435
SGTC_172 1112-0046 2.638 µM 0.0330416182520328 0.465769716864065 no 1555 0.486820699590326 530 2802135 YIL048W NEO1
SGTC_706 4262-0057 46.9 µM 0.0327489340866396 0.465893420100374 no 1556 0.486937400520214 526 883298
SGTC_147 4466-0538 29.23 µM 0.0325041531357754 0.465996879529282 no 1557 0.487035002028899 507 6742687 YHR072W ERG7
SGTC_1242 0402-0103 60.1 µM 0.0313648024705053 0.466478469064841 no 1558 0.487489305446066 524 432868
SGTC_1236 0330-0013 258 µM 0.0313292838987578 0.466493483121565 no 1559 0.48750346834587 529 4617066
SGTC_2974 9094440 9.66 µM 0.0308460094893957 0.466697772793475 no 1560 0.487696173797124 535 25236134
SGTC_2097 5376186 200 µM 0.030750078605996 0.466738325724717 no 1561 0.487734426536456 525 742755
SGTC_2414 st077232 92.9 µM 0.0307399690607312 0.466742599360167 no 1562 0.48773845775578 537 729801
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0306860355071127 0.466765398902137 no 1563 0.487759963984966 530 5282362
SGTC_873 0591-4978 488 µM 0.0296684051611989 0.467195606114311 no 1564 0.488165754926469 540 3305145
SGTC_2597 laccaic acid a 100 µM 0.0295609188707053 0.467241048610807 no 1565 0.488208616952565 534 5491415 A textile dye.
SGTC_13 0199-0087 65 µM 0.0286912237387036 0.467608749461079 no 1566 0.4885554279649 537 4589825
SGTC_2892 9047358 58.44 µM 0.028601089300122 0.467646859239895 no 1567 0.488591371652597 525 6466771
SGTC_1620 st003704 16.5 µM 0.0284465119906595 0.467712216825444 no 1568 0.488653013995442 533 2834414
SGTC_3080 9117754 49.47 µM 0.0275511361145013 0.468090812130762 no 1569 0.489010077292882 536 9550191
SGTC_103 0844-0104 51.839 µM 0.0256074239200678 0.46891277848469 no 1570 0.489785232290556 532 5375804
SGTC_2564 betulinic acid 100 µM 0.0254676500414544 0.468971891883507 no 1571 0.489840975820409 523 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2193 5925765 200 µM 0.0252376461937568 0.469069166977646 no 1572 0.489932704595326 526 877370
SGTC_2352 9027995 87.8 µM 0.0234519881614379 0.469824434334691 no 1573 0.490644867917934 532 2997347
SGTC_139 0099-0334 718.624 µM 0.0228139763062269 0.470094316240789 no 1574 0.490899329723258 540 97690
SGTC_1401 3807-4679 7.6 µM 0.0227982011546142 0.470100989375962 no 1575 0.490905621461781 534 3291456
SGTC_2416 tofa 880 nM 0.0221453812792847 0.470377149706918 no 1576 0.491165993157182 535 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1044 1222-0021 1.78 µM 0.0207105430696624 0.470984174671498 no 1577 0.49173827933561 535 4306703
SGTC_468 gf-109203x 121 µM 0.0204278696481574 0.471103770938822 no 1578 0.491851025861005 544 2396 A protein kinase C inhibitor.
SGTC_1579 chlormadinone acetate 49.4 µM 0.0202254663871642 0.471189407314332 no 1579 0.491931756399789 541 45114258 A steroidal progestin.
SGTC_593 1203-0218 61.7 µM 0.0186852507235594 0.471841112536667 no 1580 0.492546097209852 540 3666956
SGTC_956 1185-0240 191 µM 0.017827416606278 0.472204117220959 no 1581 0.492888266472132 534 1416193
SGTC_1761 st044296 37 µM 0.0160485746499223 0.472956932686902 no 1582 0.49359781985393 540 1826700
SGTC_2537 larixol 68.93 µM 0.0160405668461145 0.472960321852899 no 1583 0.493601014094272 543 6708759
SGTC_1272 0839-0021 27 µM 0.0159176503126909 0.473012344418798 no 1584 0.493650044436479 535 5027250
SGTC_2817 7995342 71.43 µM 0.0154147921375649 0.473225176329076 no 1585 0.493850631204905 541 18879975
SGTC_2022 5136654 200 µM 0.0150989983918716 0.473358838176995 no 1586 0.493976600019511 545 1713771
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0150112225527453 0.473395990430501 no 1587 0.494011613544682 539 16486 A toxic proline analog.
SGTC_1372 2752-0194 270 µM 0.0144463487159896 0.473635086073928 no 1588 0.494236941155973 539 823334
SGTC_600 1495-0418 41.6 µM 0.0134293058434414 0.47406559638916 no 1589 0.494642643132968 539 5377768
SGTC_1529 apigenin 74 µM 0.0127570085543841 0.474350193891414 no 1590 0.494910827952973 543 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_868 0527-0199 213 µM 0.0120859567641088 0.47463427720187 no 1591 0.495178518227235 541 2849450
SGTC_1965 Pectolinarigenin 58.4 µM 0.0120025766444158 0.474669576276036 no 1592 0.495211779669703 540 5320438 An anti-inflammatory.
SGTC_3296 9122258 64.045 µM 0.0118553785559254 0.474731893249421 no 1593 0.495270499032697 539 4730474
SGTC_1731 st035964 63 µM 0.0117821835364587 0.474762880920633 no 1594 0.49529969758132 532 6739575
SGTC_1673 st016611 27.3 µM 0.0116438390782735 0.474821450521754 no 1595 0.49535488524905 547 5226799
SGTC_3322 9139058 2.11 µM 0.0115239612216539 0.474872202530335 no 1596 0.495402706385922 533 4908926 YPR165W RHO1
SGTC_2106 5357045 167.29 µM 0.0110520089496336 0.475072014243087 no 1597 0.4955909761049 540 668842
SGTC_2611 pyromycin 23.93 µM 0.0100423219797202 0.475499509143727 no 1598 0.495993760506026 544 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_452 diindolylmethane 8 µM 0.0095619162568586 0.475702919737291 no 1599 0.496185405451787 545 3071 Inhibits expression of several cancer promoting factors.
SGTC_1527 coumarin 137 µM 0.0087148585860837 0.476061591356894 no 1600 0.496523318450623 544 323 A hepatotoxic, DNA x-linker.
SGTC_1259 0671-0132 43 µM 0.00856064642323497 0.476126891870952 no 1601 0.496584837907425 541 X1259
SGTC_2449 5812982 45.77 µM 0.00727010394073138 0.476673391809538 no 1602 0.497099673704325 543 776185
SGTC_899 1083-0020 478 µM 0.0065467866937996 0.476979710806105 no 1603 0.497388228644022 546 767123
SGTC_574 1315-0397 40 µM 0.00652553515189608 0.476988710868585 no 1604 0.497396706601513 547 6794277
SGTC_43 0570-0105 72.5 µM 0.00570099751587898 0.477337912913133 no 1605 0.497725643370411 543 1114046 YDL195W SEC31
SGTC_2973 9094665 17.96 µM 0.00460720243439098 0.477801175675993 no 1606 0.498161998656888 547 25237061 YIL048W NEO1
SGTC_3212 9128307 49.47 µM 0.00458742930532517 0.477809550607049 no 1607 0.498169886910727 542 27243542
SGTC_520 3584-0023 682 µM 0.004462424641694 0.477862496699584 no 1608 0.498219756045727 544 1340790
SGTC_1180 1193-0155 285 µM 0.00391466137312774 0.478094508036185 no 1609 0.498438280053588 546 2921347
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.00113018905471084 0.479274015962443 no 1610 0.499549119897216 546 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2431 5490079 200 µM 0.000151292631590461 0.479688722060073 no 1611 0.499939642972776 547 5722345
SGTC_495 decylubiquinone 155 µM -9.55192224921761e-05 0.479793286540231 no 1612 0.499961893343615 549 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_601 0986-0029 62.9 µM -0.00215950675438744 0.480667770667659 no 1613 0.499138482120473 550 24747981
SGTC_1107 amlodipine 47 µM -0.00230266836200679 0.480728429840046 no 1614 0.49908136904446 548 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2798 7813637 45.45 µM -0.00274438275330644 0.480915591968319 no 1615 0.498905151060436 551 956368
SGTC_2339 9000433 200 µM -0.00397394333298906 0.481436600357976 no 1616 0.498414630157305 551 2988954
SGTC_3333 9141820 12.094 µM -0.00421304213092134 0.481537918701893 no 1617 0.498319244337023 551 1939433
SGTC_2164 5685496 200 µM -0.00451926477148445 0.481667682578998 no 1618 0.498197080343393 553 759046
SGTC_2255 7941087 197.44 µM -0.00708921177517957 0.482756789903622 no 1619 0.497171837377306 554 935561
SGTC_2046 4110841 106 µM -0.00819415801773293 0.483225090583093 no 1620 0.496731040496436 554 44119630 YMR134W ERG29
SGTC_987 1497-1013 404 µM -0.0088398807338611 0.483498772921159 no 1621 0.496473443751186 553 1676435
SGTC_995 3931-2021 34.6 µM -0.00893669959772543 0.483539809185203 no 1622 0.496434820138561 553 730143
SGTC_1587 estradiol valerate 56.1 µM -0.00906709277322711 0.483595076054028 no 1623 0.496382802895443 553 13791 A steroid.
SGTC_2912 7964298 10.93 µM -0.00928488716916713 0.483687388445761 no 1624 0.49629591916047 553 2975850
SGTC_904 1141-0088 396 µM -0.0094541654576007 0.483759137836708 no 1625 0.496228389858337 563 1378119
SGTC_883 0850-0245 24.6 µM -0.0105418765820219 0.484220181709012 no 1626 0.4957944776109 552 6823229 YPR165W RHO1
SGTC_2695 st077686 51.995 µM -0.0106452565305693 0.484264002072196 no 1627 0.495753237292632 555 2876092
SGTC_2907 7721985 69.9 µM -0.0106792739837803 0.484278421323455 no 1628 0.495739667063655 559 3267881
SGTC_1202 1988-0068 29.6 µM -0.0114215600769374 0.484593065181227 no 1629 0.495443555843615 552 2850480
SGTC_2399 5884133 200 µM -0.0115002891769719 0.484626437823153 no 1630 0.495412149539642 554 722445
SGTC_419 nsc-638432 893 µM -0.0121765040574722 0.484913084365385 no 1631 0.495142397741514 555 368090
SGTC_3067 9117431 49.47 µM -0.0124431461445209 0.48502611572469 no 1632 0.495036030998847 553 17150885
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0132605304908716 0.485372617859725 no 1633 0.494709968761747 551 17037758
SGTC_2489 cantharidin 73.42 µM -0.0136761887069795 0.485548826195662 no 1634 0.494544160165588 555 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1199 1638-0010 4.46 µM -0.0147622635810659 0.486009254833308 no 1635 0.494110922799488 551 3111136
SGTC_141 0443-0274 32.331 µM -0.0154231540813504 0.486289440736098 no 1636 0.493847295668509 555 1627241
SGTC_3132 9126706 49.47 µM -0.0154373398688906 0.486295454904937 no 1637 0.493841637031758 554 850858
SGTC_3209 9113616 49.47 µM -0.0170461706980335 0.486977550443877 no 1638 0.493199891111343 564 16649353
SGTC_297 0986-0032 24 µM -0.0177001960321809 0.487254848379177 no 1639 0.492939012130943 552 2847425
SGTC_641 4092-0595 30 µM -0.0199774280784364 0.488220411319345 no 1640 0.492030689378192 557 786260
SGTC_1124 fisetin 1.16336 µM -0.0230784104292159 0.489535360311257 no 1641 0.490793863540618 574 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2273 7815444 169.05 µM -0.0232727957333727 0.489617791921889 no 1642 0.490716335847413 558 2824616
SGTC_1908 st060353 56.5 µM -0.0242014680057959 0.490011613508757 no 1643 0.49034595358752 565 4227716
SGTC_255 tunicamycin 200.472 nM -0.0242926595679032 0.490050285600246 no 1644 0.490309584110537 558 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_844 0330-0132 15.3 µM -0.0246754389218957 0.490212613895906 no 1645 0.490156923007728 560 2828079
SGTC_1121 fusaric acid 630.51 nM -0.0247171088647303 0.490230285299463 no 1646 0.490140304174446 566 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1314 1222-0010 41.1 µM -0.0259923541971248 0.490771100882844 no 1647 0.489631718429525 562 3526027
SGTC_796 1234-0020 70.7 µM -0.0261873347536011 0.490853791216425 no 1648 0.489553958910992 557 46495034
SGTC_2952 9073731 13.78 µM -0.0262456170394369 0.490878508535192 no 1649 0.489530715631944 562 16457353
SGTC_2030 5175110 200 µM -0.0269615386970934 0.49118213129858 no 1650 0.489245205272254 568 2831986
SGTC_3218 9131285 49.47 µM -0.0271210282197329 0.491249771593753 no 1651 0.489181601417266 566 17156417
SGTC_815 1582-0027 36.9 µM -0.027848222384604 0.491558181394721 no 1652 0.488891602479183 560 3128206
SGTC_2348 9022543 33.42 µM -0.0295678571858585 0.492287514233658 no 1653 0.488205850174715 568 3162678 YDL140C RPO21
SGTC_710 3448-4187 58 µM -0.0298261874799861 0.492397079764631 no 1654 0.488102836732836 561 3946412
SGTC_2066 5222451 176 µM -0.0304306475439964 0.492653451412289 no 1655 0.48786180148143 563 2281147
SGTC_2569 tetrandrine 100 µM -0.0318935938690865 0.493273948032081 no 1656 0.487278453697193 570 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2732 terfenadine 20 µM -0.034268046489837 0.49428108651076 no 1657 0.486331702552143 565 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_967 1306-0166 352 µM -0.0345495551937387 0.494400492676903 no 1658 0.486219463291607 561 4437607
SGTC_1101 ebselen 5.29 µM -0.0363233393489532 0.495152881106809 no 1659 0.485512270053916 565 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1449 4112-4002 201 µM -0.0365093246924998 0.495231771807123 no 1660 0.485438121819063 566 2059539
SGTC_1380 2291-0730 164 µM -0.0366748539666703 0.495301985670758 no 1661 0.485372129389125 566 2999191
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0367960688867673 0.495353402456177 no 1662 0.485323804250761 568 75037 A free radical scavenger.
SGTC_3068 9116768 49.47 µM -0.0398755433217522 0.496659673432923 no 1663 0.484096174596621 564 41904888
SGTC_2073 5212005 126 µM -0.0399177082116192 0.496677559483563 no 1664 0.4840793666216 562 691789
SGTC_3249 9135183 49.47 µM -0.0407377515486611 0.4970254174014 no 1665 0.483752482589914 571 4902779
SGTC_1369 1866-0067 208 µM -0.040819155597996 0.497059948683555 no 1666 0.483720034063106 577 3531355
SGTC_2148 5546263 113.568 µM -0.041242290406503 0.497239441177993 no 1667 0.483551369733617 577 792097
SGTC_3047 9092122 49.47 µM -0.0416969621792111 0.497432312178259 no 1668 0.483370137843307 575 17173831
SGTC_840 0245-0196 390 µM -0.042182476267581 0.497638267098373 no 1669 0.483176616019131 568 3827528
SGTC_2812 7970281 58.44 µM -0.0427316233139093 0.497871215854506 no 1670 0.482957735413079 581 2233435
SGTC_1659 st012954 42.1 µM -0.0429816963432652 0.49797729734257 no 1671 0.482858062285266 582 24207262
SGTC_2036 5160441 105 µM -0.0450472356277667 0.498853508086572 no 1672 0.482034829279005 571 134534 YIL048W NEO1
SGTC_1248 0469-0687 58.6 µM -0.0452338333204586 0.498932663974511 no 1673 0.481960463375188 576 4017482
SGTC_2675 theaflavin digallate 100 µM -0.0458043089403109 0.499174663485545 no 1674 0.481733112189836 567 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2467 5474540 200 µM -0.046601795164053 0.49951296287745 no 1675 0.481415300626331 566 5413519
SGTC_251 melphalan 456.522 µM -0.0475218549080869 0.499903259257872 no 1676 0.481048656156664 581 460612 A DNA alkylator.
SGTC_590 k048-0076 22.4 µM -0.0476311514927298 0.499949623718469 no 1677 0.481005102448296 572 6832814
SGTC_3332 9141069 11.198 µM -0.047749905283143 0.5 no 1678 0.480957780385311 579 17332883
SGTC_3350 9150499 3.57 µM -0.0497082673478789 0.499169248178676 no 1679 0.480177434107532 570 4910996 YPR165W RHO1
SGTC_922 1866-0035 480 µM -0.0516073688153399 0.49836363855137 no 1680 0.47942077385036 601 3156169
SGTC_295 k015-0027 31 µM -0.0526731537486416 0.497911529242901 no 1681 0.478996164763759 575 3887424
SGTC_1256 0570-0116 285 µM -0.0529904388271718 0.497776936410196 no 1682 0.478869762861089 585 410638
SGTC_2524 avocatin b 10.57 µM -0.0535642184156326 0.497533538853277 no 1683 0.47864118256665 570 6710748
SGTC_2938 9059746 27.26 µM -0.0540780948427528 0.497315553020736 no 1684 0.478436472243963 594 6471769
SGTC_1826 st055655 41.6 µM -0.0549115558270218 0.496962001492633 no 1685 0.478104462775983 567 676168
SGTC_1790 st045711 43.5 µM -0.0556680207056117 0.496641113528613 no 1686 0.477803137880792 572 585119
SGTC_3131 9127911 49.47 µM -0.0564733380080634 0.496299505046124 no 1687 0.477482367403422 595 45595681
SGTC_32 0928-0142 34.1 µM -0.0570564132928525 0.496052171342546 no 1688 0.477250128490571 578 2244242
SGTC_358 0075-0058 9.45 µM -0.0580829705504813 0.495616721528942 no 1689 0.476841269511273 618 1069125
SGTC_464 bw-b 70c 158 µM -0.058202744273422 0.4955659156865 no 1690 0.476793567407994 598 5353454
SGTC_929 2805-0021 398 µM -0.0585069045110722 0.495436896751534 no 1691 0.476672431456582 622 3098024
SGTC_837 0091-0265 12.5 µM -0.0587711484677115 0.495324809923814 no 1692 0.476567194456443 578 759367
SGTC_2458 5808907 16.39 µM -0.0591012851171989 0.49518477329663 no 1693 0.476435717528733 569 2731747
SGTC_2349 9023730 187.07 µM -0.0591360383155551 0.495170031796733 no 1694 0.476421877215734 591 4126287
SGTC_70 0141-0289 43.283 µM -0.0598535273708578 0.494865691100146 no 1695 0.476136146639862 570 352408
SGTC_1895 st058434 18.3 µM -0.0603978704829688 0.494634796514191 no 1696 0.475919377335719 615 5393175
SGTC_3028 9087778 49.47 µM -0.0614548792167571 0.494186449219531 no 1697 0.475498473807844 564 17217395
SGTC_867 0518-0118 155 µM -0.0636180767131723 0.493268917636646 no 1698 0.474637168881414 577 6848158
SGTC_2771 fluoxetine 41.05 µM -0.0638642816720654 0.493164490676108 no 1699 0.474539146645443 571 3386 A selective serotonin reuptake inhibitor.
SGTC_2857 9024691 58.44 µM -0.0639097920875092 0.493145187645814 no 1700 0.474521027631145 599 16478292
SGTC_2301 7769476 200 µM -0.0639194896240602 0.493141074483022 no 1701 0.474517166767829 591 977820
SGTC_1876 myriocin 605 nM -0.0644039174806539 0.492935607709396 no 1702 0.474324305403278 571 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1224 0823-0416 294 µM -0.0645800674480127 0.49286089536314 no 1703 0.474254177723568 582 3598164
SGTC_1057 3448-5381 134 µM -0.0647010508986649 0.492809581519229 no 1704 0.474206013040791 590 5497911
SGTC_2823 7987624 58.44 µM -0.0654454058419889 0.49249387393653 no 1705 0.473909686454931 586 2239440
SGTC_2264 7948757 110.76 µM -0.0662289840582854 0.492161535443084 no 1706 0.473597760742159 578 2971411
SGTC_996 3970-0799 1.8 µM -0.0671386956401519 0.491775706932239 no 1707 0.473235644355056 584 6615648 YGL040C HEM2
SGTC_481 bay k-8644 50 µM -0.0672678723284954 0.491720920898556 no 1708 0.473184226552295 611 2303 A calcium channel antagonist.
SGTC_2997 9067075 71.4286 µM -0.0672711990071443 0.491719509999538 no 1709 0.473182902398944 573 27209819
SGTC_535 2293-4129 48.2 µM -0.0680395146968744 0.491393657516044 no 1710 0.472877089485292 617 396118 YIL048W NEO1
SGTC_1129 3453-1384 223 µM -0.0688645064592844 0.491043774387717 no 1711 0.472548735581718 628 1084452
SGTC_3299 9121982 43.1275 µM -0.0697229491626151 0.490679711867956 no 1712 0.472207087719647 600 17594604 YPL160W CDC60
SGTC_2674 ligustilide 100 µM -0.0703185830021365 0.490427110204035 no 1713 0.471970046010576 581 5319022 A signalling regulator.
SGTC_158 k038-0087 26.446 µM -0.0703449456537396 0.490415930185683 no 1714 0.471959554813994 578 X158
SGTC_1835 st008666 49.2 µM -0.070984159880616 0.49014485102462 no 1715 0.471705181135298 588 690455
SGTC_1651 st011928 86.1 µM -0.0710052548530033 0.490135905106304 no 1716 0.471696786640757 581 720198
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0715312182651853 0.48991285709513 no 1717 0.471487489801826 581 688761
SGTC_497 capsazepine 133 µM -0.0726756050980199 0.489427562073943 no 1718 0.471032130757173 578 2733484 A calcium channel blocker.
SGTC_2764 methyldopa 94.69 µM -0.0733203340689296 0.489154161580986 no 1719 0.470775605500549 589 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_463 ikarugamyin 104 µM -0.0735157313980177 0.489071303382404 no 1720 0.470697863051188 581 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1007 4101-0031 70 µM -0.0736678243247843 0.489006808733291 no 1721 0.470637350833779 623 1146276
SGTC_2514 salinomycin 42.74 µM -0.074444771312232 0.488677350705163 no 1722 0.470328242628352 600 23682228 A polyether potassium ionophore.
SGTC_1516 st013856 110 µM -0.0752854692628333 0.488320868311258 no 1723 0.469993791259365 612 5281404 A mutagen and neurotoxin.
SGTC_1423 4048-0112 5.59 µM -0.0753213217214023 0.488305665945708 no 1724 0.46997952869383 584 X1423
SGTC_2887 9044784 58.44 µM -0.075474759176191 0.488240604706456 no 1725 0.469918489751649 585 6465546
SGTC_2029 5175081 200 µM -0.0755664459943003 0.488201727398984 no 1726 0.469882016162836 580 1380876
SGTC_1175 0741-0056 27.6 µM -0.0761944558805997 0.487935439879708 no 1727 0.469632196717596 588 765927
SGTC_666 0272-0154 136 µM -0.0763066556955326 0.487887865697279 no 1728 0.469587565402881 581 6870312
SGTC_3356 9151811 4.48 µM -0.076935452247051 0.487621250980887 no 1729 0.469337447150805 576 1859254 YPR165W RHO1
SGTC_1834 st055981 52.8 µM -0.077084513186902 0.487558048768911 no 1730 0.469278156513193 583 471719 YDL150W RPC53
SGTC_723 4182-0001 115 µM -0.0772718589132409 0.487478614154895 no 1731 0.469203638644638 589 744821 YLR208W SEC13
SGTC_326 k292-0812 17.5 µM -0.0784637617606333 0.486973258946925 no 1732 0.468729577623277 612 3579357
SGTC_2881 9058953 51.95 µM -0.0786535251516812 0.486892803025091 no 1733 0.468654106227475 574 17122249
SGTC_565 1418-0001 44.5 µM -0.0790044833424102 0.486744005106839 no 1734 0.468514528510457 604 2862145
SGTC_935 2996-0153 430 µM -0.0790462145437543 0.486726312193246 no 1735 0.468497932073245 583 23738523
SGTC_2926 9010726 65.15 µM -0.0790725665524956 0.486715139659576 no 1736 0.468487451946442 614 2994293
SGTC_1994 st072947 40.9 µM -0.0796677208904683 0.486462813230774 no 1737 0.468250766410924 617 5286565 YDL195W SEC31
SGTC_2048 5246248 200 µM -0.0807486312990596 0.486004555673894 no 1738 0.467820930437566 582 677046
SGTC_3107 9121808 49.47 µM -0.0810022694309389 0.48589702713113 no 1739 0.467720073846394 584 662681
SGTC_1431 4049-0260 9.09 µM -0.0825166220250324 0.48525504697557 no 1740 0.467117950472474 578 3854841
SGTC_2085 5307070 144.047 µM -0.0827094319016157 0.485173311708374 no 1741 0.467041292499556 606 2840351
SGTC_657 3534-0529 86.7 µM -0.0841287557345096 0.484571656464641 no 1742 0.466477030955837 598 1049549
SGTC_2355 9061122 103.12 µM -0.08658707481675 0.483529652193721 no 1743 0.465499870056678 593 5302957
SGTC_1269 0831-0796 3.05 µM -0.0866772576194867 0.483491428630671 no 1744 0.465464027079537 574 927758
SGTC_1747 st037496 66.6 µM -0.0874153577101478 0.483178594061502 no 1745 0.465170681210268 584 723305
SGTC_3326 9140064 16.379 µM -0.0877001894337283 0.4830578744267 no 1746 0.465057484529455 591 1868434
SGTC_2619 obliquin 87.91 µM -0.0886907096932166 0.482638076456212 no 1747 0.464663858014831 595 6708593 A bioactive alkalod. YER133W GLC7
SGTC_685 1278-0033 54.9 µM -0.0888493726755804 0.482570834380389 no 1748 0.464600809547675 586 3590572
SGTC_3117 9124945 49.47 µM -0.0904636087962751 0.481886742464156 no 1749 0.463959405659401 586 17592065
SGTC_299 1273-0059 1.44 µM -0.0904811653397857 0.481879302522757 no 1750 0.463952430218269 593 2848077
SGTC_2775 cyproheptadine 69.59 µM -0.0905506647218459 0.481849850811965 no 1751 0.463924817326342 583 2913 A selective serotonin reuptake inhibitor.
SGTC_99 0109-0120 622.8 µM -0.0906931677192067 0.481789462713552 no 1752 0.463868199814509 593 759414
SGTC_603 3794-0023 45.9 µM -0.091278998774814 0.481541211123011 no 1753 0.463635452432982 612 3802260
SGTC_823 0417-1665 178 µM -0.0931995068220379 0.480727427921458 no 1754 0.462872533092157 612 3429856
SGTC_807 1315-0151 48 µM -0.0934054123782285 0.480640183588788 no 1755 0.462790745431123 623 4011080
SGTC_1013 4112-3890 241 µM -0.0944916743350329 0.480179938511996 no 1756 0.462359297886651 582 705171
SGTC_17 0960-0276 49.807 µM -0.095420048140851 0.479786610963103 no 1757 0.461990596309405 590 6821114
SGTC_2037 5169046 200 µM -0.0961170605514916 0.479491318062726 no 1758 0.461713800840198 599 5718022
SGTC_1357 1503-1303 39.5 µM -0.0971261420504361 0.479063835470394 no 1759 0.461313110324939 588 292895
SGTC_2854 9024559 71.43 µM -0.0971948971099377 0.479034709267583 no 1760 0.461285810188228 609 3163529
SGTC_479 n-linoleoylglycine 10 µM -0.0980934440793384 0.478654074738812 no 1761 0.46092904664385 611 6433346 An anti-infammatory.
SGTC_1671 st016596 74.5 µM -0.0983587610071635 0.478541687233121 no 1762 0.460823709895468 588 2829167
SGTC_2950 9072895 21.46 µM -0.0990136441796082 0.478264287882163 no 1763 0.46056371842545 602 17332245
SGTC_1706 st031321 9.9705 µM -0.10061102996349 0.477587702044384 no 1764 0.459929620247583 591 6103185
SGTC_918 glabranin 770.725 nM -0.100828941978585 0.477495408588253 no 1765 0.45984312576836 611 124049 Also referred to as licorice root.
SGTC_891 0929-0073 133 µM -0.100859895617087 0.477482298723857 no 1766 0.459830839684588 638 5603632
SGTC_35 0133-0054 64.071 µM -0.101489934263626 0.477215462349183 no 1767 0.459580773797889 606 99677
SGTC_1923 st058458 19.1 µM -0.10158131376584 0.477176761798685 no 1768 0.459544506084264 640 3534982
SGTC_1634 st006576 41 µM -0.101954933715698 0.477018530549738 no 1769 0.459396223146637 587 3915356
SGTC_2585 alliin 100 µM -0.104646092544898 0.475878910294195 no 1770 0.458328319452312 605 87310 A garlic compound which reacts with lipids.
SGTC_1399 3562-5772 25 µM -0.105160444651063 0.47566112069081 no 1771 0.458124248616001 578 23847490
SGTC_1707 st032323 6.317 µM -0.10555298222307 0.47549491531018 no 1772 0.457968515507458 591 3132057 YMR211W DML1
SGTC_2477 5967686 25.23 µM -0.10708269916474 0.474847254729867 no 1773 0.457361686153937 599 776118
SGTC_1148 3909-7663 27.7 µM -0.107635445872164 0.474613245825982 no 1774 0.457142439289028 635 4084526
SGTC_1290 0986-0249 10.2 µM -0.10804999923331 0.474437747714574 no 1775 0.456978015341905 602 53329
SGTC_2420 aureobasidin a 50 nM -0.108147433802656 0.474396500226108 no 1776 0.456939371019396 622 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_385 1494-0393 12.4 µM -0.108423057165106 0.474279820626839 no 1777 0.456830055986744 619 3090647
SGTC_2788 5282734 71.43 µM -0.109230737597519 0.473937918124753 no 1778 0.456509740543949 613 743706
SGTC_2217 6934799 96.0675 µM -0.109998751663993 0.47361282475506 no 1779 0.456205182467842 606 675606
SGTC_1293 1000-1278 195 µM -0.110153032827504 0.473547521054283 no 1780 0.456144004948583 618 678847
SGTC_2626 ethyl orsellinate 100 µM -0.110167529687973 0.473541384900108 no 1781 0.456138256523438 594 75653 A natural product.
SGTC_803 4488-1585 147 µM -0.111034062255772 0.473174615047333 no 1782 0.455794667974867 627 747204
SGTC_1143 3454-2408 5.08 µM -0.111308568089633 0.473058432031434 no 1783 0.455685830637874 598 X1143
SGTC_165 k038-0023 64.381 µM -0.111397616196217 0.473020743424168 no 1784 0.455650525148506 601 46368543
SGTC_1376 2910-0861 41.3 µM -0.11147021565128 0.472990016701937 no 1785 0.455621741423497 592 1112859
SGTC_2980 9014342 25.29 µM -0.111935082774873 0.47279327189374 no 1786 0.455437439679763 595 2996599
SGTC_2603 homopterocarpin 100 µM -0.11336113093629 0.472189769921824 no 1787 0.454872127019358 600 101795 A weak amylase inhibitor.
SGTC_1366 1683-0113 21.9 µM -0.113584269072528 0.472095343855667 no 1788 0.454783679049968 603 708623
SGTC_199 4063-0024 41.6 µM -0.11464812332079 0.471645170966551 no 1789 0.454362017135271 591 306215
SGTC_2717 st081029 62.2815 µM -0.115031703655785 0.471482866734139 no 1790 0.454209996474882 610 5292846
SGTC_595 3909-8003 73.7 µM -0.115455591741227 0.471303512605126 no 1791 0.454042008838924 601 699517
SGTC_1348 1493-0373 93.8 µM -0.116523549671817 0.470851667650938 no 1792 0.453618811641759 611 3010129
SGTC_359 0081-0058 15.9 µM -0.117129345935234 0.470595376457731 no 1793 0.453378777547463 580 3494159
SGTC_1279 0874-0590 65.2 µM -0.117998211887036 0.470227810975645 no 1794 0.453034537346474 606 3523074
SGTC_799 1310-0557 151 µM -0.118987497107976 0.469809334166419 no 1795 0.452642630634576 641 5354492
SGTC_2825 7998094 58.44 µM -0.119025288130538 0.469793348872215 no 1796 0.452627660580929 618 2987815
SGTC_626 0214-0009 33 µM -0.119667071721812 0.469521887104023 no 1797 0.452373442914073 622 3437874
SGTC_2909 7941780 10.49 µM -0.119761585080716 0.469481911015864 no 1798 0.452336006761091 618 1243215
SGTC_368 fentichlor 4.58 µM -0.120463660102968 0.469184965688908 no 1799 0.452057932503093 612 7329 A pesticide.
SGTC_144 4161-2749 112.381 µM -0.120616067695107 0.469120506571021 no 1800 0.451997570791154 600 797501 YMR168C CEP3
SGTC_2910 7948405 25.97 µM -0.120627593527056 0.469115631879833 no 1801 0.451993005978715 585 2971328
SGTC_1230 0170-0365 3.77 µM -0.121858073194971 0.468595244303025 no 1802 0.451505710418618 608 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3007 9078383 71.4286 µM -0.122423916127723 0.468355959130955 no 1803 0.451281649319611 608 6496995
SGTC_256 clotrimazole 625 nM -0.122533822344429 0.468309483019389 no 1804 0.451238130722943 602 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3353 9151644 39.2805 µM -0.122814318138794 0.468190871544161 no 1805 0.45112706793136 620 4909158
SGTC_2888 9058547 12.99 µM -0.123191355926695 0.468031440419891 no 1806 0.450977785200931 604 16476514
SGTC_895 0964-0006 13.7 µM -0.12388406527419 0.467738540376551 no 1807 0.450703534909072 604 6738897
SGTC_2306 7482397 179.52 µM -0.124219110329505 0.467596878686304 no 1808 0.450570895785972 628 891448
SGTC_94 0334-0113 514.748 µM -0.124242892864365 0.467586823256916 no 1809 0.450561480860203 601 6795178
SGTC_563 tetrahydrosecaminediol 614 µM -0.124316896261599 0.467555534212569 no 1810 0.450532184897314 608 334274 A psychoactive constituent of the cannabis plant.
SGTC_2809 7964133 12.99 µM -0.125116290644813 0.467217558678144 no 1811 0.450215743284703 624 1253665
SGTC_2483 5729050 27.16 µM -0.125885878448708 0.46689220737673 no 1812 0.449911130554341 620 2865180
SGTC_1192 1488-0095 21.4 µM -0.125904697832749 0.466884251561286 no 1813 0.449903681969503 616 915875
SGTC_210 3551-0445 56.827 µM -0.126407636851637 0.466671641118058 no 1814 0.449704628656163 643 2865180 YOR207C RET1
SGTC_2297 7971671 152.32 µM -0.127943431927615 0.466022464320952 no 1815 0.449096869880573 615 909016
SGTC_507 nimesulide 162 µM -0.129324906791235 0.465438595474798 no 1816 0.448550282075334 618 4495 A COX2 inhibitor.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.129666301034455 0.465294319456189 no 1817 0.448415222652025 624 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_449 xestospongin c 11.1929 µM -0.129798586894254 0.465238415587743 no 1818 0.448362890476216 626 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2094 5332512 191.667 µM -0.131221871025722 0.464636980801467 no 1819 0.44779989748853 611 755774
SGTC_435 c-PAF 6.7 µM -0.13225253212048 0.464201506425146 no 1820 0.447392275684722 606 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3176 9106582 49.47 µM -0.133677975088468 0.463599299795515 no 1821 0.446828611079272 600 17018027
SGTC_1402 3909-7673 35.9 µM -0.136546748522699 0.462387583817785 no 1822 0.445694535310492 605 5328014
SGTC_908 3448-7491 47.7 µM -0.136547478840403 0.462387275389269 no 1823 0.44569424665943 604 1203031
SGTC_2299 7976368 114.88 µM -0.137685113196462 0.461906856061452 no 1824 0.445244642642211 618 2979718
SGTC_1453 4237-0541 195 µM -0.138198391083795 0.461690118612645 no 1825 0.445041813313176 601 739892
SGTC_20 0481-0013 4.944 µM -0.138928417684687 0.461381876157319 no 1826 0.444753357328107 607 182045
SGTC_715 0868-0130 184 µM -0.139889318968844 0.46097618582526 no 1827 0.444373720266807 613 2876258
SGTC_1288 0973-0013 65.5 µM -0.140327994999455 0.460790991281385 no 1828 0.444200423175848 609 4315430
SGTC_179 1273-0063 6.77 µM -0.140506175069359 0.460715771962003 no 1829 0.44413003694537 648 3108139
SGTC_597 k018-0003 82.8 µM -0.140677891460315 0.460643282636579 no 1830 0.444062205720564 633 6786234
SGTC_39 0986-0283 58.349 µM -0.141604868276023 0.460251986064776 no 1831 0.443696060679347 599 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2964 9083345 53.42 µM -0.143287767035978 0.459541697440237 no 1832 0.443031458315743 601 17741579
SGTC_1618 st003135 44.5 µM -0.145185899710345 0.458740721682327 no 1833 0.442282049187763 605 1270615
SGTC_2532 xanthone 78.9 µM -0.14607755935826 0.45836451594914 no 1834 0.441930080705284 634 7020 An insecticide.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.146429668759076 0.458215965508283 no 1835 0.441791103722628 643 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2056 5235370 200 µM -0.146560008086293 0.458160978496426 no 1836 0.441739660827685 632 5511916
SGTC_2440 5628896 157.78 µM -0.147421418314444 0.457797590523215 no 1837 0.441399700425019 609 5522048
SGTC_2308 7584454 197.62 µM -0.148527182557131 0.457331172967855 no 1838 0.440963367641395 645 893577
SGTC_2967 9089538 49.85 µM -0.148692896569774 0.457261278916109 no 1839 0.440897983320965 616 728216
SGTC_3129 9127257 49.47 µM -0.150032556233401 0.456696292492843 no 1840 0.440369464899949 669 837894
SGTC_361 000s-0510 1.45 µM -0.151279628682633 0.456170432325823 no 1841 0.439877569143364 624 660
SGTC_1118 chelidonine 707.474 nM -0.151964614121576 0.455881623202845 no 1842 0.439607422645951 609 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3175 9106517 49.47 µM -0.152848640338226 0.455508927366573 no 1843 0.439258819462893 633 41468073
SGTC_1726 st035556 14.5795 µM -0.15531840082749 0.454467911714124 no 1844 0.438285154941885 645 5919439
SGTC_1510 1123-0200 71.5 µM -0.155322294646603 0.454466270696064 no 1845 0.438283620157793 665 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3101 9120531 49.47 µM -0.156154014157017 0.454115767202423 no 1846 0.437955811686325 671 24824904
SGTC_2178 5812956 200 µM -0.15671783773186 0.453878180800814 no 1847 0.437733614159574 606 5403383
SGTC_2276 7947513 42.08 µM -0.158570211771362 0.453097736096876 no 1848 0.437003749683207 653 2105100
SGTC_1853 st056710 91.2 µM -0.159236379900949 0.452817109376658 no 1849 0.436741321251021 647 269167
SGTC_2330 7979373 200 µM -0.160698100109892 0.452201435060456 no 1850 0.436165592939776 616 1863007
SGTC_356 1634-0012 32.5 µM -0.161703648819695 0.451777966112836 no 1851 0.435769615509175 640 735457
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.163031262721462 0.451218949249686 no 1852 0.435246909934357 626 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_63 0099-0242 26.702 µM -0.16368115867395 0.450945333503212 no 1853 0.434991075344861 623 3898502 YLR359W ADE13
SGTC_1680 diphenhydramine 100 µM -0.163708565295133 0.450933795424223 no 1854 0.434980287197164 610 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_201 4262-0159 12.803 µM -0.163875569058446 0.450863488397598 no 1855 0.434914550068377 624 1341029
SGTC_3319 9138450 16.7555 µM -0.164880775607149 0.45044033845979 no 1856 0.434518912067278 649 2029690
SGTC_502 l-744,832 89.3 µM -0.165826766488215 0.450042167283186 no 1857 0.434146640567841 646 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_229 benomyl 22.8748 µM -0.165920438022815 0.450002743305932 no 1858 0.434109781605864 631 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1665 st014639 11.4 µM -0.168670726122474 0.448845438222255 no 1859 0.433027822998243 611 981133 YIL048W NEO1
SGTC_1612 st002233 45.4 µM -0.170123915232659 0.448234119841371 no 1860 0.432456343012618 611 1035021
SGTC_3018 9082602 49.47 µM -0.170490288266719 0.448080015699347 no 1861 0.432312285697793 628 17332089
SGTC_1637 st007924 17.4 µM -0.170770759317355 0.447962049017522 no 1862 0.432202010990777 602 683336
SGTC_618 k072-0232 33.2 µM -0.171014200504088 0.447859660900543 no 1863 0.432106299848111 641 5872756 YGL099W LSG1
SGTC_1215 3852-0577 11.2 µM -0.171031407099769 0.447852424167206 no 1864 0.432099535067391 608 2884876
SGTC_2469 5655019 90.81 µM -0.171204089799162 0.447779798406405 no 1865 0.43203164589033 640 2788239
SGTC_2323 6148992 148.28 µM -0.171274884893643 0.447750024374208 no 1866 0.432003813799624 621 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3227 9130768 49.47 µM -0.17174408445769 0.447552702290326 no 1867 0.431819363159615 618 17720899
SGTC_2132 5317594 122.667 µM -0.172039342917839 0.447428537865228 no 1868 0.431703299458084 614 794577
SGTC_2476 5806916 10.51 µM -0.173175930937478 0.446950619066811 no 1869 0.431256571057633 630 2870194
SGTC_1588 farnesol 29.9 µM -0.175369295969656 0.446028559193729 no 1870 0.430394732479794 603 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1572 epiandrosterone 68.9 µM -0.175497364468027 0.445974729962612 no 1871 0.430344420747125 609 441302 A steroid.
SGTC_743 1275-0778 158 µM -0.175706111626968 0.445886992339227 no 1872 0.430262416812151 645 2849257 YMR203W TOM40
SGTC_3149 9097855 49.47 µM -0.177453480800378 0.445152667424199 no 1873 0.429576101104132 609 25236625 YMR079W SEC14
SGTC_2294 7971431 200 µM -0.17822976949401 0.444826495415512 no 1874 0.429271265661231 654 5741572
SGTC_1774 st048371 48.465 µM -0.178952821881424 0.444522725216489 no 1875 0.42898737314624 616 4242727
SGTC_2531 methyl deoxycholate 70.07 µM -0.179275153108728 0.444387317273093 no 1876 0.428860827861606 647 16667744 Haematoxylin.
SGTC_2064 5220758 200 µM -0.179449017432804 0.444314281401008 no 1877 0.428792572817672 629 788518
SGTC_558 k064-0027 21.3 µM -0.180566173620234 0.443845038410842 no 1878 0.428354054464161 633 5088526
SGTC_1036 k216-0215 33.5 µM -0.180769543284505 0.44375962479512 no 1879 0.428274235082184 618 622330
SGTC_1153 4055-0057 267 µM -0.181246003580896 0.443559525557605 no 1880 0.428087243435293 619 882706
SGTC_2417 cerulenin 830 nM -0.181837166462828 0.443311274634465 no 1881 0.427855258052948 649 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1490 4089-0339 670 nM -0.182913914808239 0.442859165843659 no 1882 0.427432782328396 649 742542
SGTC_2831 7999036 19.48 µM -0.182973322381933 0.442834223747815 no 1883 0.427409475438877 679 2988270
SGTC_2911 7942208 15.64 µM -0.183213810841229 0.442733257688247 no 1884 0.427315129149808 625 1243384
SGTC_2288 7946289 167.31 µM -0.183229509834172 0.442726666792449 no 1885 0.427308970405289 657 1246052
SGTC_1813 st051246 8.6015 µM -0.184410736370559 0.442230798979552 no 1886 0.426845623927201 617 5291959
SGTC_1874 staurosporine 7.6 µM -0.184760694920057 0.44208390700827 no 1887 0.426708368964737 625 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2054 5233173 129 µM -0.184852945707512 0.442045186890733 no 1888 0.426672189361809 629 6889
SGTC_3185 9108267 49.47 µM -0.18563082099215 0.441718713928934 no 1889 0.426367140985895 645 4910486
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.185722213187183 0.441680359371497 no 1890 0.426331303886124 613 6708630 An antioxidant.
SGTC_1872 amphotericin b 148 nM -0.186896915996893 0.441187420718285 no 1891 0.425870728636419 645 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_795 0685-0265 78 µM -0.187395527802885 0.440978216542244 no 1892 0.425675264395517 628 302754
SGTC_2916 7875993 68.79 µM -0.188102502867892 0.440681616961219 no 1893 0.4253981495578 654 1299250
SGTC_2153 5569715 200 µM -0.188508990428388 0.440511096949439 no 1894 0.42523883425739 637 2054701
SGTC_72 0744-0168 198.391 µM -0.188688706991357 0.440435710038077 no 1895 0.425168401556099 692 677577
SGTC_3140 9094243 49.47 µM -0.189970609175831 0.439898044717539 no 1896 0.424666080797763 652 19291112
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.189997512442249 0.439886761925527 no 1897 0.424655539905415 627 368090
SGTC_2791 5663188 71.43 µM -0.190310922587491 0.439755326411689 no 1898 0.424532747539057 653 54690634
SGTC_2424 5537928 59.2 µM -0.190690102539255 0.43959631774429 no 1899 0.424384196716737 640 5382802
SGTC_1245 0418-0076 17.2 µM -0.190717344711693 0.439584894146158 no 1900 0.424373524500601 681 6790114
SGTC_2496 diffractaic acid 79.83 µM -0.191036874966099 0.439450907664307 no 1901 0.424248351549542 623 94870 An apoptosis inducer which activates caspases.
SGTC_428 3448-4153 16.5 µM -0.191095508590565 0.439426321971897 no 1902 0.42422538321174 623 3834874
SGTC_3054 9094397 49.47 µM -0.1915863784387 0.439220504281649 no 1903 0.424033106643265 656 2598354
SGTC_2766 oltipraz 83.91 µM -0.193432056739397 0.438446774030341 no 1904 0.423310305917909 631 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1195 1502-0147 41.1 µM -0.193455438488845 0.438436973625923 no 1905 0.42330115085541 635 817940
SGTC_2818 7996756 12.99 µM -0.194189518635315 0.438129304914735 no 1906 0.423013744788627 611 2241621
SGTC_1498 4478-3555 97.6 µM -0.194488271299686 0.438004101970202 no 1907 0.422896789269773 639 3437919
SGTC_1861 st057647 17.4 µM -0.194503969168077 0.43799752339085 no 1908 0.422890644065232 636 688668
SGTC_984 1492-0255 2.91 µM -0.195565501083778 0.437552702081369 no 1909 0.422475132480649 652 1585198
SGTC_2226 7298446 200 µM -0.196470685585457 0.437173458458681 no 1910 0.422120887510567 650 3283010
SGTC_575 k072-0246 11.9 µM -0.197051863638198 0.436929993676548 no 1911 0.42189347601717 631 6796779
SGTC_621 3584-0052 32.1 µM -0.19783445131431 0.436602192933794 no 1912 0.421587295300696 671 2273927
SGTC_2529 gangaleoidin 93.61 µM -0.198243766302648 0.436430761407279 no 1913 0.421427173189672 613 4565183
SGTC_2360 9040895 200 µM -0.199313845920251 0.435982641338801 no 1914 0.42100862449109 643 4914414
SGTC_1210 3013-0140 750 nM -0.19945578606507 0.435923206849528 no 1915 0.42095311301549 656 905973
SGTC_2398 5228213 48.84 µM -0.199645440656116 0.435843795185017 no 1916 0.420878943315004 638 80771 YMR134W ERG29
SGTC_3155 9099265 49.47 µM -0.20028559093641 0.435575772285051 no 1917 0.420628615502635 660 25236499
SGTC_897 1000-0139 31.4 µM -0.200304979705067 0.435567654911659 no 1918 0.420621034114385 662 6151020
SGTC_341 1486-1430 230 µM -0.200393368877365 0.435530649918832 no 1919 0.420586472590133 637 2054753 YPL210C SRP72
SGTC_3041 9091929 49.47 µM -0.200418685323785 0.435520051044527 no 1920 0.420576573583425 633 25236887
SGTC_2421 5690543 90.72 µM -0.200902095252768 0.435317677622712 no 1921 0.420387564671066 663 3397993
SGTC_2278 7948257 134.34 µM -0.200946208715682 0.435299210924891 no 1922 0.420370317619129 617 1247028
SGTC_282 k297-0036 65.7 µM -0.201554698929885 0.435044500269565 no 1923 0.420132431656584 652 5061378
SGTC_2061 5245884 80.95 µM -0.202877183969409 0.434491008391845 no 1924 0.41961551399246 655 573863
SGTC_275 trichlorophene 5.69 µM -0.203273673564397 0.434325092900544 no 1925 0.419460565703102 646 62616
SGTC_894 0960-0238 55.9 µM -0.203308172599327 0.434310656941388 no 1926 0.419447084056929 658 6741907 YDL195W SEC31
SGTC_1881 5652484 16 µM -0.203318676391752 0.434306261696169 no 1927 0.419442979369206 679 2255129
SGTC_2430 5571206 200 µM -0.204826465426228 0.433675421463621 no 1928 0.418853854472367 650 1731771
SGTC_456 gingerol 170 µM -0.204884520052254 0.433651135494929 no 1929 0.418831174937377 681 442793 A herb.
SGTC_2371 9071574 200 µM -0.204909687122109 0.433640607442401 no 1930 0.418821343290623 662 45596039
SGTC_1115 galangin 695.678 nM -0.204965621082913 0.433617208952337 no 1931 0.418799492579447 674 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_974 1326-0144 138 µM -0.205630762448011 0.433338982545437 no 1932 0.418539673024009 664 5411856
SGTC_2434 5670830 169.91 µM -0.206258900494224 0.433076264828602 no 1933 0.418294340440093 654 1549830
SGTC_3224 9130643 49.47 µM -0.20658348255345 0.432940520492121 no 1934 0.418167580508953 667 17644395
SGTC_2552 juarezic acid 87.02 µM -0.207408592733112 0.432595484602512 no 1935 0.417845386238384 636 1549512
SGTC_1554 st069299 38.7 µM -0.207631540202066 0.432502263584737 no 1936 0.417758337745373 633 24207999
SGTC_1777 st045864 34.765 µM -0.209468668835767 0.431734248548879 no 1937 0.417041195747252 640 4691462
SGTC_554 4483-2211 187 µM -0.210572842790901 0.431272770503748 no 1938 0.416610302729 638 747107
SGTC_2479 5617353 43.85 µM -0.210925451730294 0.431125420987204 no 1939 0.416472721639824 645 2731746
SGTC_1375 2910-0797 186 µM -0.211746404800802 0.430782395281078 no 1940 0.416152441532237 636 742508
SGTC_3340 9146634 11.102 µM -0.211802020801695 0.430759158666609 no 1941 0.416130745958733 644 4907387
SGTC_924 2046-0044 21.3 µM -0.213649289635881 0.429987498155952 no 1942 0.415410279580206 636 3623589
SGTC_1158 4092-0494 91.8 µM -0.213686573187777 0.42997192642226 no 1943 0.415395741277454 674 1148199
SGTC_583 1488-1091 88.9 µM -0.213890721324145 0.429886664470823 no 1944 0.415316138056102 668 4303273
SGTC_1797 st048695 56.8 µM -0.213962303420466 0.429856769163863 no 1945 0.41528822696385 642 592262 YIL048W NEO1
SGTC_150 3970-0969 77.2 µM -0.214274749769387 0.429726284828114 no 1946 0.415166403757899 641 6615640
SGTC_400 oxethazaine 37.5 µM -0.214428535199941 0.429662063532677 no 1947 0.415106445628497 657 4621 A local anesthetic.
SGTC_3151 9099821 49.47 µM -0.215955323177735 0.429024573148514 no 1948 0.41451128636606 685 17174189
SGTC_1742 st038235 28.8875 µM -0.216494764413743 0.428799380669147 no 1949 0.414301052895832 641 564103 YBR002C RER2
SGTC_1600 coumarin 106 71.1 µM -0.216698360902714 0.428714394302857 no 1950 0.414221712732837 684 100336 A hepatotoxic, DNA x-linker.
SGTC_514 4466-0038 2.65 nM -0.217235284000811 0.428490284771912 no 1951 0.41401249425969 666 5722064
SGTC_1444 4112-3581 28 µM -0.219164488155286 0.427685233524462 no 1952 0.41326095867049 637 2877249
SGTC_2114 5491910 81.25 µM -0.219336475752068 0.427613478166474 no 1953 0.413193975028433 663 2849228
SGTC_3269 9137823 49.47 µM -0.219705235997606 0.427459634892573 no 1954 0.413050363282408 633 17682936
SGTC_2705 st078069 42.8 µM -0.220438628384887 0.427153703353698 no 1955 0.412764782056312 669 1530061
SGTC_1410 3909-8106 77.9 µM -0.220506052728053 0.427125579769557 no 1956 0.412738529494754 648 1039210
SGTC_1407 3909-7909 12.3 µM -0.221318704865302 0.426786641004405 no 1957 0.412422143350336 634 4411780
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.22156768960195 0.426682805926646 no 1958 0.412325218638012 660 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1878 temozolomide 1 mM -0.221587352312933 0.426674606125816 no 1959 0.412317564570814 640 5394 DNA alkylating agent.
SGTC_692 k241-0027 77.8 µM -0.223457269192358 0.425894953264524 no 1960 0.411589818270936 645 3600480
SGTC_2219 9098279 200 µM -0.223805124036229 0.425749948714704 no 1961 0.411454471347766 642 902349
SGTC_1456 k015-0012 13 µM -0.224998790901317 0.425252440823494 no 1962 0.410990107435402 668 2989616
SGTC_45 0kpi-0036 14.9 µM -0.225365111213615 0.425099786168445 no 1963 0.410847625371159 647 2795021
SGTC_552 k242-0005 476 µM -0.225659856677391 0.42497696665939 no 1964 0.410732991230391 670 4088318
SGTC_1664 st014217 9.02 µM -0.227048710992856 0.424398333618164 no 1965 0.410192932597865 654 3982782
SGTC_2388 9080168 200 µM -0.227559452463049 0.424185586262696 no 1966 0.409994372578952 663 15943073
SGTC_367 0335-0881 7.1 µM -0.22809096570259 0.423964209964772 no 1967 0.40978776166125 680 23828853
SGTC_296 1222-0039 74.9 µM -0.228576332120096 0.423762074863509 no 1968 0.409599110908691 657 5984176
SGTC_1088 bifonazole 369 nM -0.22877857880734 0.423677853374233 no 1969 0.409520508452189 649 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1355 1499-0035 1.68 µM -0.230184277321964 0.423092575560781 no 1970 0.408974289368446 648 1548538
SGTC_1338 1486-1223 76 µM -0.230411838770551 0.42299784380984 no 1971 0.408885881305738 663 3444526
SGTC_874 0599-0792 117 µM -0.231318293815485 0.422620539101401 no 1972 0.408533767817986 687 765305
SGTC_701 4424-0219 185 µM -0.231491703620901 0.422548366725932 no 1973 0.408466414986752 667 2911779
SGTC_1564 D-Arginine 115 µM -0.2349581645466 0.421106190001823 no 1974 0.407120602075086 696 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1317 1273-0028 910 nM -0.235361394685184 0.420938499581728 no 1975 0.406964123537296 667 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2636 apigenin dimethyl ether 100 µM -0.236943702433875 0.420280607630357 no 1976 0.406350232765628 691 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2425 5628681 7.85 µM -0.237481147035442 0.420057199467414 no 1977 0.406141771702533 650 5714958
SGTC_1804 st050076 49.1 µM -0.239484902547505 0.419224494063134 no 1978 0.405364800966222 638 3895976
SGTC_1523 st012844 44.7 µM -0.239812875626693 0.419088231861972 no 1979 0.405237662446706 675 4274103
SGTC_3011 9081274 71.4286 µM -0.239887848850171 0.419057084275965 no 1980 0.405208600536245 638 6625322
SGTC_314 1671-0008 2.74 µM -0.239992390421257 0.419013653382522 no 1981 0.405168077904053 678 3913060
SGTC_2060 5238662 140 µM -0.240427956805837 0.418832711714876 no 1982 0.404999253657377 674 790130
SGTC_958 1222-0007 33 µM -0.241717971888721 0.418296918424775 no 1983 0.404499351445094 687 7312461
SGTC_1597 7-benzyloxygramine 47.5 µM -0.244475531500586 0.417152106482121 no 1984 0.403431275077378 666 260807
SGTC_1294 1000-1494 117 µM -0.245431219979525 0.416755511895579 no 1985 0.403061279018471 640 712797 YDL207W GLE1
SGTC_1633 st005664 67.9 µM -0.24581746516171 0.416595250678186 no 1986 0.402911768289351 681 2063822
SGTC_1228 0124-0032 52.5 µM -0.245839500559699 0.416586108147676 no 1987 0.40290323908735 659 X1228
SGTC_177 1327-0068 8.361 µM -0.24726625014302 0.41599424316384 no 1988 0.402351088206207 633 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1222 0366-0074 1.18 µM -0.247304083762142 0.415978551059011 no 1989 0.402336449273667 681 286520
SGTC_2124 5246320 200 µM -0.247400546069086 0.415938542364831 no 1990 0.402299125808828 669 579342
SGTC_1785 bathophenanthroline 24 µM -0.247914603455138 0.415725346690455 no 1991 0.402100240320307 652 72812 An iron chelator.
SGTC_1467 k284-1082 293 µM -0.250603993996089 0.414610378027693 no 1992 0.401060146741848 682 3334705
SGTC_2408 sulbentine 18.36 µM -0.251488585293269 0.414243793636341 no 1993 0.400718193145824 639 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2508 celastrol 40.54 µM -0.251807885533179 0.414111490425139 no 1994 0.400594780955124 639 122724 Celastrol is a natural product and antioxidant.
SGTC_3207 9114163 49.47 µM -0.252932144953239 0.4136457271327 no 1995 0.400160324418126 719 849233
SGTC_2134 5324836 1.464 µM -0.253605958733483 0.413366634677852 no 1996 0.399899996352869 635 699272
SGTC_2401 5128683 200 µM -0.253806062507098 0.413283760477766 no 1997 0.399822694788318 710 708373
SGTC_92 0063-0024 660.874 µM -0.254474436733346 0.413006977234027 no 1998 0.399564525364271 659 3594437
SGTC_1054 3429-0080 167 µM -0.254967125363103 0.412802975562345 no 1999 0.399374245204533 698 1162877
SGTC_2525 harmine 47.85 µM -0.25662460062671 0.412116857824837 no 2000 0.398734291142255 662 5280953 A monoamine oxidase inhibitor
SGTC_968 1309-0633 340 µM -0.256751533822757 0.412064324423984 no 2001 0.398685293213989 693 3761976
SGTC_266 formosanin C 406 nM -0.256981104520688 0.411969316799566 no 2002 0.39859667987973 666 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2426 5582046 32.21 µM -0.257168526093458 0.411891756377698 no 2003 0.398524339808264 682 2251934
SGTC_2068 5226020 147 µM -0.25887071062949 0.411187501544496 no 2004 0.397867498782897 684 1810509
SGTC_1299 1079-1439 3.74 µM -0.260942687071106 0.410330636823093 no 2005 0.397068352679087 676 323161
SGTC_2871 9038510 12.99 µM -0.261068068794473 0.410278798969334 no 2006 0.397020007696999 724 4945164
SGTC_1901 st060216 58.6 µM -0.261841236802098 0.409959174849886 no 2007 0.396721922737235 646 688792
SGTC_2568 diosmetin 100 µM -0.262464006371782 0.409701768240934 no 2008 0.396481865824527 663 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2588 indole-3-carbinol 100 µM -0.262495003830229 0.409688957213455 no 2009 0.396469918361737 678 3712 Induces cell cycle arrest.
SGTC_978 1416-0512 87.4 µM -0.2637952921771 0.409151644373969 no 2010 0.395968831210307 674 6814003
SGTC_3228 9131799 49.47 µM -0.264125253287936 0.409015322999002 no 2011 0.395841702663854 662 17015818
SGTC_2237 6667747 47.222 µM -0.264997881915021 0.408654854999223 no 2012 0.395505546746335 679 729940 YDL015C TSC13
SGTC_427 1354-0053 47.3 µM -0.266689643083303 0.407956237659927 no 2013 0.394854064412767 695 6813657
SGTC_943 3253-1379 105 µM -0.266698852540997 0.407952435388102 no 2014 0.394850518734324 690 668464
SGTC_2688 kanamycin b 96.69 µM -0.267318339620862 0.407696690165614 no 2015 0.394612033713673 669 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2207 7258803 200 µM -0.26768691761518 0.407544547355589 no 2016 0.394470160332757 679 3666799
SGTC_1829 berberine 14.4 µM -0.268106048218587 0.407371554222468 no 2017 0.394308845204352 686 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_469 w7 172 µM -0.268931901092539 0.407030742300271 no 2018 0.393991043740752 657 45115570 A P450 inhibitor.
SGTC_2166 5933061 31.504 µM -0.269065346544271 0.406975678798217 no 2019 0.393939698403479 649 2877375
SGTC_2802 7925815 54.55 µM -0.269647095858281 0.406735653485166 no 2020 0.393715882313049 666 1262923
SGTC_393 acivicin 6.25 µM -0.270909836310577 0.406214777100684 no 2021 0.393230189777461 683 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2325 6158266 200 µM -0.271522465875283 0.405962129096881 no 2022 0.392994611603733 653 3623240
SGTC_2949 9072542 2.23 µM -0.271818487631769 0.405840063957386 no 2023 0.39288079459266 695 16457352
SGTC_54 0159-0055 9 µM -0.273096412395005 0.40531321443247 no 2024 0.392389552220691 732 3319099
SGTC_106 0092-0003 11.579 µM -0.274281908308326 0.404824623850589 no 2025 0.391933993331686 672 1072148
SGTC_2693 st077581 40.7 µM -0.275056299873889 0.404505545967046 no 2026 0.391636492348548 682 25238761
SGTC_2175 5807670 165.306 µM -0.275515904714062 0.404316201837104 no 2027 0.391459954142679 652 241186
SGTC_2246 7293507 91.5585 µM -0.275811819084964 0.404194305383975 no 2028 0.391346302692981 690 887656
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.276473144151397 0.403921918389271 no 2029 0.391092341971905 654 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2988 9073640 71.4286 µM -0.276775005235104 0.403797603127374 no 2030 0.39097643731293 692 9102229
SGTC_951 1171-0579 82.7 µM -0.277323906657692 0.403571574304815 no 2031 0.390765702165 680 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2000 st075254 36.4 µM -0.277790537255711 0.403379448612677 no 2032 0.390586577791841 650 17234175
SGTC_1569 carminic acid 40.6 µM -0.280071537839855 0.402440629245939 no 2033 0.389711310353572 644 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1089 terbinafine 2.25 µM -0.280332225016339 0.40233337073899 no 2034 0.389611314767279 672 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2891 9063876 19.48 µM -0.281970254238995 0.40165957992013 no 2035 0.388983159448512 659 6472478
SGTC_1238 0333-0287 48.8 µM -0.282112381945958 0.401601130522855 no 2036 0.388928669633063 669 7226
SGTC_3257 9139206 32.98 µM -0.282210952556486 0.40156059508346 no 2037 0.388890880294558 687 4910041
SGTC_1763 st044482 94.5 µM -0.282298140381541 0.401524741498274 no 2038 0.388857455687993 664 88505
SGTC_716 1683-5115 658 µM -0.282499484205098 0.401441947579527 no 2039 0.38878027101258 702 723597
SGTC_2832 7992762 51.95 µM -0.285536575436011 0.40019361422762 no 2040 0.387616543509218 645 2985177
SGTC_2981 9013952 38.96 µM -0.285559818985836 0.40018406436188 no 2041 0.387607641115061 659 2996344
SGTC_3246 9135460 32.98 µM -0.28587899823122 0.400052932130122 no 2042 0.38748539986943 671 41446951
SGTC_483 fpl-64176 144 µM -0.286150887259545 0.39994123759204 no 2043 0.387381278920992 668 3423
SGTC_875 0709-0210 25.7 µM -0.286261663862767 0.39989573188104 no 2044 0.387338858917137 706 6251364
SGTC_779 1360-0071 233 µM -0.28722300006709 0.39950088355405 no 2045 0.386970788214965 654 7566
SGTC_1748 st037455 53.6035 µM -0.289438702039761 0.398591223277565 no 2046 0.386122840913496 694 580690
SGTC_852 0418-0143 439 µM -0.289899537772059 0.398402095384663 no 2047 0.385946547626838 687 5369229
SGTC_1080 nisoldipine 24.4 µM -0.290467403846258 0.398169074850708 no 2048 0.385729342142659 699 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1391 3442-0225 151 µM -0.290924407464437 0.397981572445763 no 2049 0.38555456691899 650 5227075
SGTC_1448 4255-0083 152 µM -0.291439269855733 0.397770359592326 no 2050 0.385357692179039 718 5399660
SGTC_2119 5528445 120.635 µM -0.293978996387087 0.396728922904981 no 2051 0.384386976520129 685 791935
SGTC_3216 9129716 49.47 µM -0.296112197649056 0.395854753905976 no 2052 0.383572199556242 664 8056934
SGTC_3302 9125395 16.351 µM -0.296546922868111 0.395676671027734 no 2053 0.383406219106857 679 17599668
SGTC_1647 st011722 22.4 µM -0.297278703388728 0.395376950221717 no 2054 0.383126869666947 691 2854783
SGTC_547 1120-0019 610 nM -0.298467774452419 0.394890065545468 no 2055 0.38267308406577 686 3676939
SGTC_2442 5158906 48.48 µM -0.298513611798069 0.394871299971494 no 2056 0.382655594363153 650 1893835
SGTC_2953 9074162 66.49 µM -0.298923762040054 0.394703397427513 no 2057 0.382499108046929 661 16451992
SGTC_57 miconazole 162.5 nM -0.300421433894213 0.394090464218198 no 2058 0.381927858223646 685 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1867 st057372 64 µM -0.301307923752083 0.39372778516979 no 2059 0.381589849621824 675 688837
SGTC_325 2810-4341 181 µM -0.301516478499982 0.393642475027545 no 2060 0.381510343152437 662 774970
SGTC_1610 st001799 48.1 µM -0.301539764236478 0.393632950221915 no 2061 0.381501466337021 661 621897
SGTC_1925 st057770 10.1 µM -0.302878538671631 0.393085444656154 no 2062 0.380991213640116 685 5989122
SGTC_60 0986-0278 202 µM -0.3029159755914 0.393070137476663 no 2063 0.380976948119648 729 3110598
SGTC_634 1611-4317 11.2 µM -0.303804830525265 0.392706751754941 no 2064 0.3806382931796 681 2843522
SGTC_1001 4048-4355 44.4 µM -0.304652222582119 0.392360404130772 no 2065 0.380315520787612 710 21824233
SGTC_2948 9070189 9.45 µM -0.304754279029982 0.392318697179698 no 2066 0.380276653012598 694 6473636 YDL196W YDL196W
SGTC_1997 st073024 93.8 µM -0.305058068495683 0.392194556222814 no 2067 0.380160963210391 695 686268
SGTC_2813 7971799 71.43 µM -0.306057241336156 0.391786330269653 no 2068 0.379780531584393 696 2234054
SGTC_348 k064-0012 10.7 µM -0.306716043635647 0.391517232564811 no 2069 0.379529758483 674 5066323
SGTC_2617 dihydrotanshinone i 20.83 µM -0.307761930722103 0.391090130916507 no 2070 0.379131745661831 647 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_606 k015-0008 38.6 µM -0.309795071281214 0.390260247577965 no 2071 0.37835839995224 694 1970475
SGTC_564 3555-0129 330 µM -0.310329303288713 0.390042268568436 no 2072 0.37815527478191 670 563260
SGTC_1173 0443-0020 122 µM -0.31108327302258 0.389734690325922 no 2073 0.37786865845737 691 5331295
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.311095600433858 0.389729661992295 no 2074 0.377863972836219 731 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1873 rapamycin 2 nM -0.311301739881079 0.389645580738739 no 2075 0.377785622361551 673 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_524 r073-0010 27.8 µM -0.311817291507045 0.389435317420139 no 2076 0.377589691032336 707 2772106
SGTC_2345 9052315 157.45 µM -0.312207108595154 0.389276355340161 no 2077 0.377441565029977 669 6469265
SGTC_1333 1482-0047 286 µM -0.312433658446283 0.389183979918862 no 2078 0.37735548697782 706 3811116
SGTC_2815 7968870 71.43 µM -0.313388330919986 0.388794782259374 no 2079 0.376992824311099 705 2977326 YHR190W ERG9
SGTC_303 1348-1668 34.2 µM -0.313682125105408 0.388675031670858 no 2080 0.376881239072949 699 5380509
SGTC_1273 0849-0096 14.1 µM -0.315423783003905 0.387965349037054 no 2081 0.376219955782748 705 5286025
SGTC_1383 3049-0032 20.7 µM -0.315641021931962 0.387876855719603 no 2082 0.376137498620311 712 712864
SGTC_941 3237-0776 460 µM -0.315877752110318 0.387780429178023 no 2083 0.376047649621159 687 760008
SGTC_86 0417-1630 471.922 µM -0.318403034774946 0.38675224568113 no 2084 0.375089618277671 678 3634867
SGTC_1973 st070275 50.2 µM -0.319617750745903 0.386257949520008 no 2085 0.374629058270511 676 17118334
SGTC_2920 7982904 15.77 µM -0.320400423106271 0.385939559653153 no 2086 0.374332402423386 706 6456808
SGTC_1775 st081588 35.1725 µM -0.321189912119252 0.385618474602104 no 2087 0.374033238222084 702 1426443 YGL099W LSG1
SGTC_1418 3966-3099 2.4 µM -0.321350029170873 0.385553364575062 no 2088 0.373972573679271 692 740335
SGTC_2328 6201408 200 µM -0.322653337187045 0.385023507279931 no 2089 0.373478897497105 721 2890418
SGTC_424 splitomicin 100 mM -0.323954809382714 0.384494610483068 no 2090 0.372986123816661 725 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2272 7805186 180 µM -0.32398810527491 0.384481082398234 no 2091 0.372973519784872 736 2956062 YPR165W RHO1
SGTC_390 dec-rvkr-cmk 16.7 µM -0.324258695956693 0.384371146916952 no 2092 0.372871093767687 677 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2594 a-mangostin 100 µM -0.32523340557409 0.383975219402251 no 2093 0.372502213899352 717 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2147 5545932 89.7195 µM -0.325353421360648 0.383926477294968 no 2094 0.372456801878221 724 797404
SGTC_167 3672-0051 66.205 µM -0.325362865138562 0.383922641963813 no 2095 0.372453228581543 690 3237971
SGTC_2001 4023502 57.655 µM -0.326904735840578 0.383296606218946 no 2096 0.371869969518212 674 108941 YCR052W RSC6
SGTC_2444 5485484 36.41 µM -0.327456100840985 0.383072812925707 no 2097 0.37166147036812 728 6790631
SGTC_292 k038-0015 474 µM -0.32875768096678 0.382544670056326 no 2098 0.371169426131339 716 46368540
SGTC_2448 5185112 27.17 µM -0.329245452875084 0.382346802787466 no 2099 0.370985084940601 668 5718189
SGTC_1020 4335-0961 93.3 µM -0.329949273085046 0.382061348525235 no 2100 0.370719145882534 721 669075
SGTC_1012 4112-3522 18 µM -0.330234146797019 0.38194582812006 no 2101 0.37061152365936 687 3112398
SGTC_1476 4112-3294 3.34 µM -0.330556658503612 0.381815057650115 no 2102 0.370489694426081 689 704369
SGTC_923 1900-2434 73.3 µM -0.330682764461911 0.381763928489273 no 2103 0.370442061261104 725 5910570
SGTC_1211 1056-0033 32.3 µM -0.332036947159914 0.381215010652605 no 2104 0.369930680164491 703 6741922
SGTC_11 0438-0307 1.3 µM -0.333061182252265 0.380799995660216 no 2105 0.369544050092588 697 4011476
SGTC_2139 5578692 56.4705 µM -0.333704205013806 0.38053951604639 no 2106 0.369301388084025 708 650991 YMR113W FOL3
SGTC_1097 itavastatin 7.23 µM -0.334103691224163 0.380377716979213 no 2107 0.369150657386424 677 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1162 k048-0130 20.1 µM -0.334419667878131 0.380249755597844 no 2108 0.369031450042969 714 6797406
SGTC_2917 7979103 53.79 µM -0.335896905475328 0.379651691273906 no 2109 0.368474305347935 718 2980565
SGTC_3245 9134821 49.47 µM -0.336589668143441 0.379371323149582 no 2110 0.368213122913574 703 17014901
SGTC_1530 rhein 70.4 µM -0.336777682349903 0.379295242817462 no 2111 0.368142249098515 677 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_519 k048-0011 62.8 µM -0.338025395553003 0.378790471696963 no 2112 0.367672025074783 684 6836379
SGTC_1019 4262-0212 3.4 µM -0.338572912207623 0.378569035191549 no 2113 0.367465745753769 699 4677213
SGTC_2873 9040596 71.43 µM -0.33910288576281 0.378354731748228 no 2114 0.367266112289803 756 6463863
SGTC_2488 5268135 45.7 µM -0.339116940175204 0.378349049126489 no 2115 0.367260818681585 718 1270356 YLR208W SEC13
SGTC_3236 9132701 49.47 µM -0.340127632681665 0.377940464791116 no 2116 0.366880206559127 719 24282524
SGTC_845 0330-0138 4.51 µM -0.342665194126296 0.37691522822234 no 2117 0.36592517507089 722 9039800
SGTC_2002 4023503 131 µM -0.342793625650265 0.376863361759651 no 2118 0.365876860865886 739 4736863 YCR052W RSC6
SGTC_1850 st056238 17 µM -0.343199619918554 0.376699417516626 no 2119 0.365724145297499 702 5393177
SGTC_154 3389-1638 511.116 µM -0.345783121055325 0.375656697887438 no 2120 0.364752855518574 748 5238686
SGTC_709 3807-1509 243 µM -0.34639156031587 0.375411259178088 no 2121 0.364524233442228 727 1886677 YPL242C IQG1
SGTC_1439 4092-1168 46 µM -0.346581400251392 0.375334689838627 no 2122 0.364452910624715 701 2886240
SGTC_2748 diazoxide 86.69 µM -0.346626286873426 0.375316586151837 no 2123 0.364436047417603 675 3019 A potassium channel activatior.
SGTC_780 0109-0199 192 µM -0.346968273235289 0.375178665121598 no 2124 0.364307577066827 731 610414
SGTC_1956 st077085 54 µM -0.347130263936253 0.375113340820367 no 2125 0.364246729075992 703 24208685
SGTC_571 k831-0106 44.2 µM -0.347383845258901 0.375011088916902 no 2126 0.364151484096446 725 4783639
SGTC_2284 7945075 39.21 µM -0.348402547739832 0.374600404875771 no 2127 0.363768944713589 699 1245402
SGTC_492 tmb-8 126 µM -0.349411239325724 0.374193896773055 no 2128 0.363390298335618 695 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_871 0574-0004 149 µM -0.349751456032919 0.374056819135563 no 2129 0.363262616604494 698 9551173
SGTC_2677 mitomycin C 100 µM -0.35020052015815 0.373875909872342 no 2130 0.363094108211479 688 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_170 4197-0004 226 µM -0.350564261540523 0.373729393956497 no 2131 0.362957636045828 689 218692
SGTC_762 1165-0429 115 µM -0.350936817157695 0.373579346559955 no 2132 0.362817874905383 728 5967793
SGTC_2385 9074692 200 µM -0.352318982376466 0.373022844793282 no 2133 0.362299526893257 687 17046906
SGTC_1021 4476-0760 85.3 µM -0.35262111499495 0.372901232242567 no 2134 0.362186252860583 688 746768
SGTC_2703 st077852 53.4 µM -0.354270125497191 0.372237706240321 no 2135 0.361568227090466 729 6281836
SGTC_1186 1319-0216 26 µM -0.354467821925756 0.372158182905573 no 2136 0.361494157471654 684 4565136
SGTC_2962 9082311 13.18 µM -0.354574825540307 0.372115143004493 no 2137 0.361454069296911 690 16459453
SGTC_467 ro 31-8220 72.8 µM -0.356572084312029 0.371312082407369 no 2138 0.360706089486689 697 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1979 st071809 45.3 µM -0.357655105520075 0.370876853623024 no 2139 0.360300717069251 734 4976333
SGTC_1981 st071826 47 µM -0.358923891009183 0.370367182683885 no 2140 0.359826013217235 687 11838600
SGTC_1609 st001574 46.4 µM -0.359521394610087 0.370127244310665 no 2141 0.359602537823982 717 3960012
SGTC_3174 9107204 49.47 µM -0.359574916053055 0.37010575427229 no 2142 0.35958252233535 723 3938802
SGTC_3286 9117135 37.221 µM -0.360116237577545 0.369888424557936 no 2143 0.359380105228462 695 3438150
SGTC_263 alizarin 107.927 µM -0.362367976975325 0.368984843014924 no 2144 0.358538533191588 704 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3354 9151612 71.43 µM -0.3647862583036 0.368015237122775 no 2145 0.357635481797147 717 27261949
SGTC_1058 3448-5425 97.3 µM -0.365912667189037 0.367563891808629 no 2146 0.357215121926304 725 7279705
SGTC_420 mitomycin C 81.9 mM -0.366312920719792 0.367403556610368 no 2147 0.357065794655552 681 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_912 3474-0017 2.18 µM -0.366341041835635 0.36739229260734 no 2148 0.357055304004487 739 3360550
SGTC_3328 9140624 29.0385 µM -0.366678617341362 0.367257084565921 no 2149 0.356929379073819 725 4904392
SGTC_3029 9088683 49.47 µM -0.368339194531289 0.36659221877331 no 2150 0.356310165344231 704 25236615
SGTC_3195 9113082 49.47 µM -0.368385913930099 0.366573518928558 no 2151 0.356292749585831 694 17018038
SGTC_930 2810-3379 265 µM -0.368597264761538 0.366488927882305 no 2152 0.356213967321434 754 1015764
SGTC_888 0916-0002 6.97 µM -0.370444154367505 0.365750005252642 no 2153 0.355525789837349 697 2802138 YIL048W NEO1
SGTC_1489 4065-0444 182 µM -0.371000928109649 0.36552734300813 no 2154 0.355318420217571 706 2877968
SGTC_2353 9059630 146.67 µM -0.371030133222204 0.365515664691671 no 2155 0.355307543995052 705 4779114
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.371339242212826 0.365392068203275 no 2156 0.355192436507944 676 115019
SGTC_1006 4099-6547 255 µM -0.372018367455605 0.365120570709201 no 2157 0.354939587009071 704 3146833
SGTC_1267 0828-0272 9.49 µM -0.372286487926213 0.365013401372974 no 2158 0.354839778928649 707 745334
SGTC_1715 st032160 10.2275 µM -0.372500736193948 0.364927772652713 no 2159 0.354760031983451 723 5289825
SGTC_2275 7947463 200 µM -0.373853414759821 0.364387302563449 no 2160 0.354256688470737 686 1225414
SGTC_1854 st056233 32.9 µM -0.374104033069526 0.364287196214212 no 2161 0.354163459126466 743 5393174
SGTC_114 0364-0001 490.298 µM -0.376059411677384 0.363506463050689 no 2162 0.353436364015478 705 4003655
SGTC_2099 5377090 177.372 µM -0.377736310993071 0.362837370727231 no 2163 0.35281324527892 727 2243829
SGTC_382 3229-0966 23.2 µM -0.377818249093024 0.362804687670199 no 2164 0.352782808012903 747 5722370
SGTC_327 1273-0057 3.96 µM -0.378819120179662 0.362405545975147 no 2165 0.35241109395249 720 3108138
SGTC_2595 hexamethylquercetagetin 100 µM -0.379123434556414 0.362284216755519 no 2166 0.352298102389733 754 386331
SGTC_1278 0874-0585 172 µM -0.379341754894818 0.362197181619568 no 2167 0.352217048340138 696 766306
SGTC_527 4476-4215 268 µM -0.380201991234035 0.361854310948772 no 2168 0.351897740623382 683 4418754
SGTC_1166 k206-0078 225 µM -0.38073319274285 0.361642641434464 no 2169 0.351700618175005 701 5404595
SGTC_637 1181-0519 7.26 µM -0.380733732310846 0.36164242645264 no 2170 0.351700417968112 715 6252091 YGR060W ERG25
SGTC_1100 amiodarone 5.07 µM -0.381881063505447 0.361185390446002 no 2171 0.351274793435798 700 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3164 9100705 49.47 µM -0.38306502479173 0.360713970603786 no 2172 0.350835775740835 723 17174235
SGTC_848 0368-0089 85.6 µM -0.383669638126184 0.360473312267078 no 2173 0.350611659391094 735 762535
SGTC_3100 9120536 49.47 µM -0.384597773217843 0.360103987928474 no 2174 0.350267722089008 741 16421196
SGTC_2645 abamectin 100 µM -0.384651648891013 0.360082553678203 no 2175 0.350247761247577 714 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3262 9137218 49.47 µM -0.384842885223683 0.360006474516824 no 2176 0.350176911865627 708 17650664
SGTC_16 erodoxin 22.806 µM -0.385297059754783 0.359825813414264 no 2177 0.350008669839984 732 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_438 sphingosine 6.67 µM -0.385448619231895 0.359765533199326 no 2178 0.349952533493544 699 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_421 streptovitacin 30 mM -0.386920366497675 0.359180352263428 no 2179 0.349407581476403 728 91467 include heat shock
SGTC_2379 9035213 200 µM -0.38708257655048 0.359115876157447 no 2180 0.34934753802357 722 646551
SGTC_2592 piperlongumine 83.33 µM -0.38727929245969 0.359037689865861 no 2181 0.349274726988081 715 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_704 1310-0270 142 µM -0.387893925329929 0.358793437235074 no 2182 0.349047266875361 746 5718033
SGTC_333 3486-0131 40.1 µM -0.388521353592818 0.358544159312883 no 2183 0.34881512743908 727 6744690
SGTC_1325 1431-0015 227 µM -0.388627482391034 0.358502000182874 no 2184 0.348775866902298 708 1103340
SGTC_2908 7930301 100 µM -0.388872495536265 0.358404676533104 no 2185 0.348685234657659 732 2223178
SGTC_2644 guaiazulene 100 µM -0.388889208192422 0.358398038298998 no 2186 0.348679052832294 709 3515 A coloring agent.
SGTC_1724 st037281 8.293 µM -0.38965367030664 0.358094441227558 no 2187 0.348396329784921 685 574124 YDL195W SEC31
SGTC_1474 0330-0125 5.35 µM -0.389771668884695 0.358047587478034 no 2188 0.348352697556647 718 X1474
SGTC_1739 st037196 92.5 µM -0.390221477121259 0.357869001529277 no 2189 0.348186390777964 723 612214
SGTC_1084 voriconazole 435 nM -0.390637102321286 0.357704014810234 no 2190 0.348032748375821 735 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2506 ethyl hematommate 54.16 µM -0.390762110361265 0.357654396775505 no 2191 0.34798654206299 717 3940691 An allergen.
SGTC_2989 9073649 71.4286 µM -0.390929271937391 0.357588050971174 no 2192 0.347924758203624 755 21367202
SGTC_338 4055-0136 114 µM -0.391375024859827 0.357411154345513 no 2193 0.347760025155898 703 2900563
SGTC_1031 k035-0009 16 µM -0.391738167505555 0.357267064172265 no 2194 0.347625842912857 740 5180959
SGTC_3060 1327-0027 12.5 µM -0.392306254307146 0.357041695707765 no 2195 0.347415971510117 721 16000455 YPR107C YTH1
SGTC_753 1322-0200 289 µM -0.393124016912668 0.356717364732125 no 2196 0.347113943145498 727 5403907
SGTC_2126 5251174 33.877 µM -0.394385861965848 0.356217110475341 no 2197 0.346648090118647 717 790722
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.394467437172715 0.356184778760622 no 2198 0.346617981825489 696 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2659 sanguinarine 24.21 µM -0.395568315602533 0.355748555155369 no 2199 0.346211757482673 744 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_7 0192-1582 4.227 µM -0.395658763605903 0.35571272347761 no 2200 0.346178390009535 726 252616
SGTC_1405 3909-7894 12 µM -0.396340890599952 0.355442534662514 no 2201 0.345926782752561 726 7104060
SGTC_2876 9059903 25.97 µM -0.396514022259485 0.355373969192453 no 2202 0.345862932761374 719 6916095
SGTC_1613 st002381 52.1 µM -0.397084875655489 0.355147926836891 no 2203 0.345652436270796 700 551167
SGTC_763 3453-1109 128 µM -0.398202742844129 0.354705429633273 no 2204 0.345240372147463 739 1560353
SGTC_2493 resveratrol 26.09 µM -0.399356207567909 0.354249046907869 no 2205 0.344815378432497 714 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2336 9001819 198.65 µM -0.400524689887545 0.353786935621374 no 2206 0.344385051055535 740 2989602
SGTC_786 4544-0069 423 µM -0.40110838566139 0.353556176276859 no 2207 0.34417016360218 696 748821 YLR208W SEC13
SGTC_890 0929-0006 47.2 µM -0.401239587163171 0.353504314241518 no 2208 0.344121868724375 716 1378169
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.401600627355068 0.353361614373473 no 2209 0.34398898404257 715 1241132 A phosphatase inhibitor.
SGTC_416 estradiol valerate 100 µM -0.402367773918019 0.353058470837109 no 2210 0.343706691571045 736 13791 A steroid.
SGTC_410 α-linolenic acid 100 µM -0.403038939634276 0.352793331286981 no 2211 0.343459789315973 725 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1693 xanthone 101.9 µM -0.407877863100567 0.350883869201545 no 2212 0.341681672802463 741 7020 An insecticide.
SGTC_302 1094-0063 18.9 µM -0.408762160535469 0.350535326179721 no 2213 0.341357105702444 723 5440289
SGTC_2223 6903751 107.57 µM -0.410195783830488 0.349970535497703 no 2214 0.34083116673602 728 5598863
SGTC_2312 7706453 155.7 µM -0.410750804723678 0.349751968303702 no 2215 0.340627634774444 724 976098
SGTC_3213 9129884 49.47 µM -0.411370771392674 0.349507884333152 no 2216 0.34040034137655 738 17190742
SGTC_1667 st014849 34.6 µM -0.411390012597936 0.349500309969462 no 2217 0.340393288055053 715 5348460
SGTC_2601 securinine 100 µM -0.413585062384329 0.348636615415362 no 2218 0.339589007366892 726 442872 A GABA receptor antagonist.
SGTC_540 1187-0821 17.3 µM -0.414227874603871 0.348383833862137 no 2219 0.339353614753882 756 847520
SGTC_3189 9110682 49.47 µM -0.414463013143799 0.348291384035158 no 2220 0.339267524581458 742 17122418
SGTC_1758 st042942 75.2445 µM -0.415008086461696 0.34807711128571 no 2221 0.339067991711934 713 669317
SGTC_1616 st002734 56.1 µM -0.415968420353594 0.347699714251246 no 2222 0.338716555852215 709 4026101
SGTC_2963 9082507 9 µM -0.416073013758334 0.347658619692321 no 2223 0.338678288184856 753 16459611
SGTC_2298 7976326 193.81 µM -0.416154480082727 0.347626612961319 no 2224 0.338648483193383 719 2235818
SGTC_658 3253-0951 102 µM -0.416680286924129 0.347420058547345 no 2225 0.338456137611023 724 1184878
SGTC_1374 2889-5571 141 µM -0.417734232494076 0.347006170133195 no 2226 0.338070720340799 717 2853281
SGTC_2406 ethylparaben 405.7 µM -0.421220010651767 0.34563859379957 no 2227 0.336797216757919 738 8434 A possible steroid mimic.
SGTC_3343 9148379 18.9835 µM -0.421464049950427 0.34554292495154 no 2228 0.336708128620845 744 1955036
SGTC_2318 6029776 164 µM -0.421732362978068 0.345437751645893 no 2229 0.336610189775873 765 818325
SGTC_1137 ixabepilone 100 µM -0.423953282019404 0.344567654897132 no 2230 0.335799942367443 707 154225 A novel microtubule stabilizer.
SGTC_1862 st057513 3.81 µM -0.425625431174388 0.343913093466794 no 2231 0.335190403101672 714 5393163
SGTC_2015 5119600 184 µM -0.425883891006303 0.34381196124386 no 2232 0.335096226831433 761 2828786
SGTC_418 lividomycin a 100 µM -0.426271728336371 0.343660226129921 no 2233 0.334954928100112 725 72394 An antibiotic.
SGTC_1670 st016595 4.04 µM -0.427081400175156 0.343343536246557 no 2234 0.334660019927829 744 597879
SGTC_2565 isoliquiritigenin 100 µM -0.42836656788036 0.342841089799511 no 2235 0.334192130498442 700 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_802 4112-3352 742 µM -0.42932202228942 0.342467727367643 no 2236 0.333844446238345 704 704594
SGTC_2375 9072683 200 µM -0.430361153780989 0.342061841173567 no 2237 0.333466474255394 761 16798029
SGTC_2711 st079103 59.1 µM -0.43096880478969 0.341824576351032 no 2238 0.333245526557943 732 54693780
SGTC_675 1309-0189 238 µM -0.431205750170692 0.341732075030075 no 2239 0.333159386633787 720 4246530
SGTC_2622 2-methoxyxanthone 59.94 µM -0.431876782723589 0.34147016160355 no 2240 0.332915484959704 729 71034 A hepatoprotective.
SGTC_288 1315-0019 35.1 µM -0.433483800792635 0.340843230352497 no 2241 0.332331666036622 728 6811474
SGTC_2109 5483026 200 µM -0.434300238066349 0.34052488932302 no 2242 0.3320352154977 765 759335
SGTC_1320 1313-0481 95.3 µM -0.435670263137508 0.339990951480594 no 2243 0.331537991990324 752 6813365 YLR208W SEC13
SGTC_615 k087-0205 167 µM -0.435712003601368 0.339974689061668 no 2244 0.331522847767922 736 9642773
SGTC_25 0118-0223 35.662 µM -0.43670802673136 0.339586718861306 no 2245 0.331161553661868 744 5333628
SGTC_1649 st011737 51.3 µM -0.437302835888097 0.339355110240963 no 2246 0.330945869485667 731 1761035
SGTC_2262 9014885 67.46 µM -0.438117396436481 0.339038032595956 no 2247 0.330650592120672 724 6457424
SGTC_380 3970-0968 6 µM -0.438945173468904 0.338715927041325 no 2248 0.330350631730433 732 2891601
SGTC_689 0833-0039 98 µM -0.44177059972453 0.337617383267265 no 2249 0.329327607773825 768 5374726
SGTC_1105 epirubicin 18.1 µM -0.441853099486849 0.337585327557553 no 2250 0.329297755589207 720 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1470 k295-0292 231 µM -0.443559122802831 0.336922707809995 no 2251 0.328680682538271 737 5045612
SGTC_67 0335-0847 266 µM -0.444909875683319 0.3363984337842 no 2252 0.328192442744498 766 4552207 YOR254C SEC63
SGTC_1683 st010134 710 nM -0.444971953319165 0.336374346935571 no 2253 0.328170011360475 768 3818134
SGTC_2397 5161689 200 µM -0.445029987304342 0.336351829678047 no 2254 0.328149041685921 752 2259942
SGTC_1041 0206-0046 107 µM -0.445153786248412 0.336303797497437 no 2255 0.328104310680116 753 50494
SGTC_919 tnp00227 403.569 nM -0.445657993493745 0.336108200064377 no 2256 0.327922156105162 751 1269246 A methoxyflavone. YNL221C POP1
SGTC_1718 roemerine 11.9335 µM -0.446110981547708 0.335932509957009 no 2257 0.327758540349419 737 235224 An aporphine alkaloid with mutagenic activity.
SGTC_549 1661-1316 519 µM -0.446280270550625 0.335866860905295 no 2258 0.327697402965429 762 2857282
SGTC_2504 purpurogallin 52.29 µM -0.44877567797314 0.334899741822859 no 2259 0.326796742895198 706 5281571 An antioxidant.
SGTC_196 k015-0023 18.111 µM -0.448890555253192 0.334855246321065 no 2260 0.326755304813258 719 5211998
SGTC_2067 5224629 34.075 µM -0.448892238432113 0.334854594391361 no 2261 0.326754697679441 744 2835000
SGTC_1231 0242-0792 125 µM -0.44955691696295 0.334597189691163 no 2262 0.326514979590623 759 3707635
SGTC_2627 acetyl isogambogic acid 100 µM -0.449641320694158 0.334564508896947 no 2263 0.326484544282314 752 6857789 A caspase activator and apoptosis inducer.
SGTC_2742 clothiapine 36.27 µM -0.450339196973634 0.334294341980545 no 2264 0.326232939968273 737 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1624 st003710 6.25 µM -0.450705900710185 0.334152415359451 no 2265 0.32610076448697 779 24207033
SGTC_2034 5197015 53.07 µM -0.45078544021224 0.334121634038229 no 2266 0.326072097980586 777 780676
SGTC_3104 9120930 49.47 µM -0.451122396680095 0.333991246236377 no 2267 0.325950668280982 756 17014836
SGTC_3044 9093193 49.47 µM -0.451802807158579 0.333728017453482 no 2268 0.325705523624273 768 25236277
SGTC_2930 9013230 14.89 µM -0.451935056247502 0.333676864055632 no 2269 0.325657884427588 736 2995857
SGTC_588 3970-1144 52.9 µM -0.452279511473018 0.333543644720693 no 2270 0.325533817013815 718 1888707
SGTC_782 0083-0095 30.5 µM -0.453679317642858 0.333002480592139 no 2271 0.32502982759028 753 3591729 An indicator and reagent.
SGTC_2860 9025725 38.96 µM -0.454430262607643 0.332712308953504 no 2272 0.324759587459114 765 40546248
SGTC_1725 st036284 20.55 µM -0.455981929133736 0.332113049096737 no 2273 0.324201486485197 716 707914
SGTC_1778 st046819 58.9 µM -0.457345303693777 0.331586862418445 no 2274 0.323711435824092 751 671715
SGTC_1177 0983-0204 23.6 µM -0.457464457718512 0.33154089136748 no 2275 0.323668621666379 738 766818
SGTC_2235 salicylic acid 500 µM -0.458938444533863 0.330972419619351 no 2276 0.323139185163798 733 338 A COX inhibitor and kinase inhibitor.
SGTC_2033 5192550 145 µM -0.459840662063469 0.330624653906271 no 2277 0.322815297184265 714 182073
SGTC_1794 st048918 76.9 µM -0.459955191971502 0.330580518045272 no 2278 0.322774191582462 742 672303
SGTC_1982 st072467 71.9 µM -0.46206585362167 0.32976756443808 no 2279 0.322017048138784 755 3163533
SGTC_1436 4092-1007 8.32 µM -0.463125606833273 0.32935968704295 no 2280 0.321637168156796 715 2881121
SGTC_3157 9099274 49.47 µM -0.464107922083104 0.328981795184131 no 2281 0.321285213106907 749 17217662
SGTC_2774 tamoxifen 10.92 µM -0.464163577574947 0.328960390016043 no 2282 0.321265277025464 748 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_718 1130-0073 349 µM -0.466096240253276 0.328217434000279 no 2283 0.320573307175041 756 6740020
SGTC_2739 tacrine 100.86 µM -0.466932590491106 0.32789613376059 no 2284 0.320274053667868 741 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1123 mangostin 811.285 nM -0.467123413854084 0.327822843081416 no 2285 0.320205791746751 720 5281650 An antioxidant.
SGTC_2783 7738165 71.43 µM -0.468091859610071 0.327450988560284 no 2286 0.31985945018587 723 17201110
SGTC_1028 k015-0029 4.8 µM -0.468122057116157 0.327439396360621 no 2287 0.319848653289221 755 4588309
SGTC_3085 9117376 49.47 µM -0.46832996612214 0.327359588898788 no 2288 0.319774321093449 734 16480349
SGTC_2810 7959871 45.46 µM -0.468407921415863 0.327329667196807 no 2289 0.319746452169313 735 2974535
SGTC_582 0987-0078 156 µM -0.469103528245072 0.32706272047836 no 2290 0.31949781862908 767 1625765
SGTC_2751 anetholtrithion 17.25 µM -0.469955803908554 0.326735770971446 no 2291 0.319193296909667 752 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2174 5790901 200 µM -0.470593762599873 0.326491124642521 no 2292 0.318965431350605 755 786020
SGTC_38 0929-0051 58.268 µM -0.471110353486692 0.326293075469403 no 2293 0.318780965958785 757 1379719
SGTC_2475 5812728 15.03 µM -0.472119224181996 0.325906438677606 no 2294 0.318420845695587 737 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_178 4092-0806 87.505 µM -0.472185220287837 0.325881153030789 no 2295 0.318397294105353 736 2169044
SGTC_10 0279-0212 42.575 µM -0.47388540706037 0.325230022416816 no 2296 0.317790813008976 745 39851 YBR002C RER2
SGTC_198 3454-2873 16.191 µM -0.474996046132297 0.324804962186535 no 2297 0.317394895731351 754 710957
SGTC_215 1287-0124 461.5 µM -0.47564743858104 0.324555769396067 no 2298 0.317162786433035 753 5560863
SGTC_85 0868-0259 160.055 µM -0.475695904899431 0.324537231549158 no 2299 0.317145519405025 748 83173
SGTC_1246 0422-0085 105 µM -0.476546427792388 0.324211986454773 no 2300 0.316842569612817 775 264295
SGTC_1849 st056239 19.2 µM -0.477461906906033 0.323862051556901 no 2301 0.316516620099682 765 5393181
SGTC_2770 toltrazuril 17.5 µM -0.477510937379513 0.323843314420974 no 2302 0.316499167181991 742 68591 Kills coccidiodes.
SGTC_2157 5649910 96.377 µM -0.477965505964003 0.323669620993705 no 2303 0.316337378126662 760 2858091
SGTC_1967 st070177 51.4 µM -0.478659479711386 0.323404523471162 no 2304 0.316090448307642 781 5729214
SGTC_1324 1418-0026 34.4 µM -0.478926246451892 0.323302642588903 no 2305 0.315995549152104 755 1372513
SGTC_1280 0880-0253 10.1 µM -0.480009624274271 0.322889026008989 no 2306 0.31561027478156 767 6836607
SGTC_1648 st011736 69.8 µM -0.481090627986178 0.322476534057441 no 2307 0.315226044344584 749 2855514
SGTC_2900 5328528 85.29 µM -0.482499300827239 0.32193933717539 no 2308 0.314725647485337 745 795359
SGTC_1398 3558-0053 112 µM -0.483009582396368 0.321744833179933 no 2309 0.31454446618256 729 4532369
SGTC_102 gallobenzophenone 83.616 µM -0.484612974764561 0.321133986246812 no 2310 0.313975454137946 758 70837
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.485102230375165 0.320947689992084 no 2311 0.31380191501165 777 688751
SGTC_1921 5740136 50 µM -0.485283200028168 0.320878792706761 no 2312 0.313737735448145 780 1774243
SGTC_660 4031-1742 102 µM -0.485488220207913 0.320800746553732 no 2313 0.313665033350778 743 6738706
SGTC_1404 3909-7820 48.3 µM -0.486001688422085 0.320605316559648 no 2314 0.313482984419305 763 23741373
SGTC_510 ag-490 170 µM -0.486374770211593 0.320463349913627 no 2315 0.313350737650809 754 5328779
SGTC_1773 st048542 73.5835 µM -0.48847917037398 0.319663067155915 no 2316 0.312605238088233 769 3237138
SGTC_3086 9117350 49.47 µM -0.488805610022027 0.319539000427565 no 2317 0.312489662951018 744 2679265
SGTC_1898 st060199 18.6 µM -0.489978011217325 0.319093583953848 no 2318 0.312074729362625 739 688866
SGTC_192 3455-0609 60.9 µM -0.490219057095158 0.319002038587763 no 2319 0.31198944846737 740 3769639
SGTC_2474 5321570 43.32 µM -0.491282979275175 0.318598109926696 no 2320 0.311613158258339 755 2841384
SGTC_800 3448-7362 155 µM -0.493569206687523 0.31773085036663 no 2321 0.310805226261081 768 15991913
SGTC_2213 7173844 200 µM -0.496683543300127 0.316551063015003 no 2322 0.309706114611503 756 892728
SGTC_2287 7945887 168.79 µM -0.497523706199142 0.31623310739909 no 2323 0.309409894962015 746 1245853
SGTC_1768 st044301 37.178 µM -0.499215130229372 0.315593408256543 no 2324 0.308813918356835 804 3931349
SGTC_1989 st071868 50.2 µM -0.499375457298176 0.3155328009357 no 2325 0.308757452876745 760 16414057
SGTC_2678 equilin 100 µM -0.500741078197464 0.315016766073204 no 2326 0.30827667914444 738 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1053 3366-3204 134 µM -0.500828580657411 0.314983713317154 no 2327 0.308245884658362 752 3632071 YPR165W RHO1
SGTC_2797 7859098 81.82 µM -0.500877903536549 0.314965082984246 no 2328 0.308228527195762 749 972681
SGTC_2083 5306046 65.942 µM -0.501683744909323 0.314660765737005 no 2329 0.307945000260235 769 539837
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.502270821321171 0.314439141926024 no 2330 0.307738515657925 750 641818 YHR062C RPP1
SGTC_1081 sertraline 6 µM -0.50342283204881 0.314004447409968 no 2331 0.307333511184182 769 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_334 1502-1024 68.5 µM -0.506045918533154 0.313015626891088 no 2332 0.306412207413213 770 3296216
SGTC_2472 5377652 49.4 µM -0.506061827767065 0.313009633705698 no 2333 0.306406623354414 786 1610903
SGTC_265 mycophenolic acid 32.932 µM -0.506692224385297 0.312772196067972 no 2334 0.306185393598222 764 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1047 2043-3044 82 µM -0.506911243425508 0.312689721153527 no 2335 0.306108548158041 812 669592
SGTC_3049 9092223 49.47 µM -0.507667607774728 0.312404972910516 no 2336 0.305843234332691 775 8623917
SGTC_1508 1080-0625 72.9 µM -0.508113959020839 0.312236987729389 no 2337 0.305686713185588 764 767111
SGTC_281 1672-3440 14.9 µM -0.509761992448208 0.311617085332857 no 2338 0.305109108069387 766 6833000
SGTC_2653 dihydrofissinolide 100 µM -0.511366954675049 0.311013896734335 no 2339 0.304547064795223 747 6857746
SGTC_1346 1488-2224 62.4 µM -0.512129890917325 0.310727342273667 no 2340 0.304280053038346 760 3722427
SGTC_1614 st002383 48.6 µM -0.512663229408258 0.310527091555529 no 2341 0.304093457639431 750 1947235
SGTC_93 0109-0045 59.227 µM -0.513105574189722 0.31036104850702 no 2342 0.303938736270023 769 88733
SGTC_769 0302-0231 76 µM -0.513327100625622 0.310277908604503 no 2343 0.303861264943109 781 571869 YER009W NTF2
SGTC_2274 7947094 46.08 µM -0.513807498768193 0.31009764625823 no 2344 0.303693292321782 740 2971028
SGTC_2159 5658611 73.75 µM -0.51586261366359 0.30932701012616 no 2345 0.30297518372584 765 793844
SGTC_3190 9110366 49.47 µM -0.517654292789221 0.308655841802127 no 2346 0.302349746955999 756 17123768
SGTC_1920 st075728 45.7 µM -0.519337520556773 0.308025881436624 no 2347 0.301762696426436 775 3400306
SGTC_3235 9132602 49.47 µM -0.52032980624763 0.307654775907893 no 2348 0.30141686239616 772 4912240
SGTC_2305 7443522 69.23 µM -0.520569449693642 0.30756518098844 no 2349 0.301333367981903 763 5415886
SGTC_2745 rifampicin 24.3 µM -0.521573355568612 0.307189977913197 no 2350 0.300983709371819 752 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2666 tannic acid 100 µM -0.522667305091426 0.306781351336267 no 2351 0.300602897128967 777 16134267 A thiamine antagonist.
SGTC_1219 1469-0211 33.1 µM -0.525276372824901 0.305807747070903 no 2352 0.299695539870075 786 6822282
SGTC_776 4476-4378 112 µM -0.528695102681803 0.304534083270839 no 2353 0.298508487509463 800 2892008
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.528872832905984 0.304467933625368 no 2354 0.298446834500865 767 94937 An inhibitor of serotonin biosynthesis.
SGTC_957 1187-1561 14.1 µM -0.529855814746014 0.304102191870413 no 2355 0.298105951678059 770 1538454
SGTC_902 1120-0002 2.07 µM -0.530089963749496 0.304015100050843 no 2356 0.298024778610389 772 3280475
SGTC_500 h-89 112 µM -0.530285209790224 0.303942486707042 no 2357 0.297957099840643 799 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2563 tomatine 8.54 µM -0.530463183126227 0.303876303939274 no 2358 0.297895414469081 823 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2176 5809774 33.9695 µM -0.530826242243842 0.303741313440217 no 2359 0.29776959661774 761 2870539
SGTC_1323 1348-1351 11.2 µM -0.531157451887353 0.30361818837161 no 2360 0.297654837324597 779 6989654
SGTC_1738 st035555 74 µM -0.531353712029468 0.303545240433219 no 2361 0.297586845582785 789 5331140
SGTC_1477 0139-0234 16 µM -0.532706043343865 0.303042805290478 no 2362 0.297118541048585 772 620880
SGTC_3282 9108498 15.4605 µM -0.532739303554307 0.30303045272806 no 2363 0.29710702747623 780 16459645
SGTC_1547 harmine 94.2 µM -0.533181270892379 0.302866331167813 no 2364 0.296954052537218 760 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_257 daunorubicin 18.5 µM -0.533815852516977 0.302630753222316 no 2365 0.296734472451765 771 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1565 sinapyl alcohol 95.1 µM -0.533985476755217 0.302567796935896 no 2366 0.29667579109154 778 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3097 9117246 49.47 µM -0.536432241151754 0.301660330563557 no 2367 0.295829926910946 762 16423892
SGTC_3183 9108214 49.47 µM -0.536952510870411 0.301467528631532 no 2368 0.295650208818097 767 4974831
SGTC_3035 9091303 49.47 µM -0.538209559801591 0.301001919551361 no 2369 0.295216190443931 780 25237002
SGTC_1591 genipin 88.4 µM -0.53821918340215 0.300998356234556 no 2370 0.295212868857249 808 442424 A DNA cross-linking agent.
SGTC_415 dibenzyl ketone 100 µM -0.539171233400645 0.300645936086838 no 2371 0.294884353781668 785 7593
SGTC_2447 5741742 33.78 µM -0.539671590126847 0.300460793842364 no 2372 0.29471176789158 757 1776504
SGTC_1136 pergolide 1.05886 µM -0.5400493012869 0.300321067092883 no 2373 0.294581516470778 790 47811 A dopamine receptor agonist.
SGTC_3142 9086498 49.47 µM -0.540668542822556 0.300092054535032 no 2374 0.294368032239292 760 25236367
SGTC_1946 st076057 65.1 µM -0.543736909159164 0.298958455530874 no 2375 0.293311264894305 788 953009
SGTC_1276 0871-0068 94.2 µM -0.544012234642609 0.298856832489848 no 2376 0.293216526849145 775 3414906
SGTC_801 0866-0028 10.1 µM -0.544681155550641 0.298609998212943 no 2377 0.292986413819738 774 6849771
SGTC_2418 pentamidine 31.67 µM -0.54758945859316 0.297537903149219 no 2378 0.29198691459745 779 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1991 st073000 8.92 µM -0.548747373454399 0.297111547723258 no 2379 0.291589415264994 796 4301969 YIL048W NEO1
SGTC_1419 3993-2473 62.6 µM -0.548943585254695 0.297039328332223 no 2380 0.291522082937183 787 704026
SGTC_2646 retinol 96.75 µM -0.549495765950639 0.296836131091577 no 2381 0.291332634730346 786 445354 A vitamin A analog and teratogen.
SGTC_443 clozapine 122 µM -0.549689312605613 0.296764922825565 no 2382 0.291266244223274 785 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1910 st062352 60.4 µM -0.550648469082773 0.296412152471346 no 2383 0.290937337970423 752 2245730
SGTC_1313 1220-0047 237 µM -0.551230832099408 0.296198057674652 no 2384 0.29073772343163 771 3528706
SGTC_3166 9102297 49.47 µM -0.552387222110488 0.295773143084467 no 2385 0.290341541630762 782 25237072
SGTC_3297 9117502 71.43 µM -0.553016403925076 0.295542068429593 no 2386 0.290126088784099 768 7453720
SGTC_1709 st033179 39.1045 µM -0.553690081436586 0.295294744253023 no 2387 0.289895482219495 764 573381
SGTC_2151 5563267 85.4165 µM -0.554562966747036 0.294974427561835 no 2388 0.289596812747949 794 5310824
SGTC_1924 st058459 75.1 µM -0.555806910152054 0.294518223086344 no 2389 0.289171430555079 778 688683
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.556315911107419 0.294331645722142 no 2390 0.288997455973331 770 2333 A French combination drug.
SGTC_1176 0848-0131 83.3 µM -0.557280067062362 0.293978378252055 no 2391 0.288668046195765 792 6769040
SGTC_1800 st050079 29.0735 µM -0.561063445376842 0.292594043268654 no 2392 0.287377143323078 777 3645560
SGTC_2229 7354935 190 µM -0.561539368352978 0.292420118128001 no 2393 0.287214950182326 797 318112
SGTC_2684 capsaicin 100 µM -0.563569920519231 0.291678597283643 no 2394 0.286523431254051 799 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3087 9117406 49.47 µM -0.564339544901215 0.291397773641306 no 2395 0.286261536804072 764 42546093
SGTC_831 k061-1017 217 µM -0.564478504017053 0.291347083127195 no 2396 0.286214262709972 782 1240153
SGTC_3178 9107506 49.47 µM -0.564855079529462 0.291209733869981 no 2397 0.286086169812626 775 8897194
SGTC_792 4534-1957 155 µM -0.564895785209805 0.291194889003719 no 2398 0.286072325327208 759 1717904
SGTC_989 1501-0895 10.3 µM -0.568325386606264 0.289945425999969 no 2399 0.284907022023696 799 2830112
SGTC_1464 k208-0027 110 µM -0.56871749360341 0.289802734941367 no 2400 0.284773937039513 789 X1464
SGTC_1048 3161-0300 24.5 µM -0.571336553176683 0.288850482966765 no 2401 0.283885764113107 762 2165101
SGTC_343 4130-2827 29.8 µM -0.571901224211826 0.288645369944427 no 2402 0.283694447310999 772 1118244
SGTC_1435 4092-0789 56.7 µM -0.572065785982629 0.288585606880983 no 2403 0.283638703582701 790 2248285
SGTC_1077 5-fluorocytosine 377 nM -0.575448044669048 0.287358582274853 no 2404 0.282494159490633 806 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_234 nsc-17383 10.7 µM -0.577325805755026 0.286678430422247 no 2405 0.281859692120754 782 408974
SGTC_955 1216-0110 33 µM -0.578594727802909 0.286219241398956 no 2406 0.281431331494734 797 3619719
SGTC_1832 st054113 55 µM -0.5788573107411 0.286124263279503 no 2407 0.281342728420994 785 1251267
SGTC_2671 danthron 100 µM -0.579176940134861 0.286008671259945 no 2408 0.281234894397196 783 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1931 st074438 57.1 µM -0.580688572316021 0.28546229959692 no 2409 0.280725182497547 825 2787313
SGTC_2289 7946404 165.07 µM -0.580860133684739 0.285400321039031 no 2410 0.280667361436972 773 1246120 YPR165W RHO1
SGTC_399 oxolinic acid 75 µM -0.581533149301777 0.285157248147425 no 2411 0.280440591678988 758 4628 A DNA gyrase inhibitor.
SGTC_1789 tunicamycin 25 nM -0.582098540646218 0.284953122182538 no 2412 0.280250154045889 803 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1408 3909-7976 48.8 µM -0.582992050495028 0.284630676175784 no 2413 0.279949325859813 781 24152374
SGTC_2380 9035439 200 µM -0.585787860896924 0.28362286302916 no 2414 0.279009041130665 780 6462575
SGTC_1927 st060202 13.8 µM -0.585905826313852 0.283580377338236 no 2415 0.278969400892845 795 688887
SGTC_1106 tegaserod maleate 11.7 µM -0.588253815932742 0.282735374996411 no 2416 0.278180970032313 786 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_794 k038-0031 316 µM -0.589147562331981 0.282414048749281 no 2417 0.277881144945839 800 6624242
SGTC_1096 rimcazole 32.2 µM -0.592478101287182 0.281218178318534 no 2418 0.276765240314935 791 18528119 A dopamine reuptake inhibitor.
SGTC_1433 4060-0023 7.6 µM -0.592537163874459 0.281196993264615 no 2419 0.276745471088616 791 3840627
SGTC_1049 3226-0134 66 µM -0.592791947781943 0.281105614114194 no 2420 0.27666019862439 790 5702385
SGTC_2041 5107442 45.335 µM -0.593051984776934 0.281012365718822 no 2421 0.276573181307353 804 793005
SGTC_2105 5350118 200 µM -0.594157704582668 0.280616025287406 no 2422 0.276203319335212 783 2133313
SGTC_864 0469-0573 172 µM -0.594403216097781 0.280528059464964 no 2423 0.276121228967701 806 689425
SGTC_2400 5203494 178.7 µM -0.59444651956759 0.280512545384532 no 2424 0.27610675106159 806 6777674
SGTC_219 mitoxanthrone 164.414 µM -0.595018654951781 0.28030760878899 no 2425 0.275915500639095 805 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1460 k062-0059 9.15 µM -0.595707812875354 0.280060851507964 no 2426 0.275685218968237 768 1373085
SGTC_2182 6325192 200 µM -0.596794110732838 0.279672109718241 no 2427 0.275322425191919 782 736248
SGTC_971 1315-0384 26.7 µM -0.599522315318393 0.278696952662796 no 2428 0.274412316845356 818 6769120
SGTC_1847 st056231 15 µM -0.599959530214553 0.278540830593811 no 2429 0.274266603441983 784 5393180
SGTC_1284 0929-0043 16 µM -0.600875545526195 0.278213875158291 no 2430 0.273961441096628 792 1239883
SGTC_482 fipronil 114 µM -0.601208888583692 0.27809494071922 no 2431 0.273850432488071 795 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1492 4158-0558 28.5 µM -0.603134533671588 0.277408370083294 no 2432 0.273209597314298 769 3967268
SGTC_1475 4092-1048 11.7 µM -0.603166139927232 0.277397108086102 no 2433 0.273199085273248 804 2881759
SGTC_403 arphamenine a 50 µM -0.603591323136747 0.277245627782264 no 2434 0.27305769150617 801 5487158 An arginine aminopeptidase inhibitor.
SGTC_287 k060-0039 29.6 µM -0.603654352795505 0.277223175608043 no 2435 0.273036734215462 791 5861974
SGTC_1907 st060210 83.7 µM -0.603833934893763 0.277159210465243 no 2436 0.272977027742127 796 688793
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.606044699171302 0.276372353032955 no 2437 0.272242535737055 808 689007
SGTC_2144 5628481 200 µM -0.607181226793943 0.275968265873506 no 2438 0.27186532472771 796 2818399
SGTC_2184 6075246 200 µM -0.607545339305855 0.275838868748673 no 2439 0.271744531610995 800 2267320
SGTC_1119 parthenolide 318.541 nM -0.608023811614912 0.275668876147907 no 2440 0.271585840636472 826 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2473 5854593 8.94 µM -0.608742312350363 0.275413702542557 no 2441 0.271347628118641 813 2872951
SGTC_2779 methotrexate 400 µM -0.609457757796891 0.275159729541603 no 2442 0.271110532058075 796 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_624 k048-0052 28 µM -0.61082602715368 0.274674334699729 no 2443 0.270657380411375 795 6835531
SGTC_2393 9031399 185.94 µM -0.611621312131522 0.274392400785557 no 2444 0.270394167099228 819 1526623 YDL150W RPC53
SGTC_3261 9137475 49.47 µM -0.613596642653304 0.273692751331188 no 2445 0.269740951330347 761 17027690
SGTC_855 0428-0020 25 µM -0.614370600153729 0.273418861359387 no 2446 0.269485229444472 780 6812414
SGTC_655 k060-0012 42 µM -0.614972203387319 0.273206058317318 no 2447 0.269286538785262 813 5994525
SGTC_143 4032-1194 15.74 µM -0.616008095314761 0.272839828231542 no 2448 0.268944588460498 802 1806963
SGTC_1392 3455-1037 33.9 µM -0.616158431054274 0.272786698651429 no 2449 0.26889498040504 792 981132
SGTC_1825 st052143 62.6 µM -0.616991197149631 0.272492486956503 no 2450 0.268620266007654 802 674173
SGTC_97 0535-0701 19.132 µM -0.618808133825337 0.271851120610664 no 2451 0.268021381602232 789 2832013 YGL099W LSG1
SGTC_646 4092-0839 27.3 µM -0.620870375826663 0.27112407435387 no 2452 0.267342457035402 813 877796
SGTC_19 0279-0214 38.434 µM -0.62344638946791 0.270217261370935 no 2453 0.266495610786798 809 3566274 YBR002C RER2
SGTC_2697 mebhydrolin 72.4 µM -0.625055850081934 0.269651466999938 no 2454 0.265967201551603 802 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2096 5468907 200 µM -0.626651648187731 0.269091062132073 no 2455 0.265443802480961 800 759785
SGTC_1015 4130-4525 82 µM -0.628351731709839 0.268494678478197 no 2456 0.264886774837533 806 1363237
SGTC_517 1365-0151 113 µM -0.628473414169107 0.268452018171776 no 2457 0.264846928713197 804 768657
SGTC_940 3232-1287 54.8 µM -0.631761532160087 0.267300538130364 no 2458 0.263771356789592 816 1585493 YIL048W NEO1
SGTC_1438 4092-1045 4 µM -0.631991292925167 0.267220170481295 no 2459 0.263696283398657 818 1351342
SGTC_977 1348-1378 135 µM -0.63229305140392 0.267114637396973 no 2460 0.263597701608575 812 X977
SGTC_1545 lovastatin 49.4 µM -0.633181773204762 0.266803949685895 no 2461 0.263307473445693 803 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1450 4112-4260 37.6 µM -0.633769477974734 0.266598594689729 no 2462 0.263115637510218 816 1633175
SGTC_2874 9043904 71.43 µM -0.633782541917165 0.266594030813037 no 2463 0.26311137404867 804 4463428
SGTC_3317 9138495 8.753 µM -0.634326719420189 0.266403957988912 no 2464 0.262933811255971 821 17020139
SGTC_605 1315-0399 119 µM -0.634889609142639 0.266207421440717 no 2465 0.262750207225224 825 24020461
SGTC_3259 9138485 49.47 µM -0.634930295672935 0.266193218323396 no 2466 0.262736938586904 795 17646153
SGTC_1190 1486-1332 13 µM -0.636466467618357 0.26565724232115 no 2467 0.26223621509164 819 4150046
SGTC_2263 7948595 193.29 µM -0.636965218316331 0.265483344134366 no 2468 0.262073749815127 798 2971371
SGTC_2179 6298986 200 µM -0.638126497975508 0.265078667503391 no 2469 0.261695669403049 800 738374
SGTC_312 4092-0653 6.84 µM -0.640338240217132 0.264308798851967 no 2470 0.260976362463864 817 1148278
SGTC_362 0310-0100 9.03 µM -0.641047011761716 0.264062329000319 no 2471 0.2607460697459 793 790235
SGTC_220 paclitaxel 373.376 µM -0.641817363598091 0.263794577948805 no 2472 0.260495887116844 805 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2845 9003024 42.97 µM -0.642443435103246 0.263577076408179 no 2473 0.260292652649846 785 2990173
SGTC_1128 3448-9350 235 µM -0.642828058866362 0.263443500862211 no 2474 0.26016783713956 781 619386
SGTC_932 2857-0803 154 µM -0.643963650032702 0.263049324428793 no 2475 0.259799502832728 815 674898
SGTC_486 niguldipine 82 µM -0.64418623944745 0.262972096491877 no 2476 0.259727336467392 809 1236 A calcium channel blocker.
SGTC_783 0848-0141 92.7 µM -0.644348617895812 0.262915766207955 no 2477 0.259674697802794 825 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3219 9131112 49.47 µM -0.645666030713742 0.262458974139445 no 2478 0.259247832161535 809 17612988 YMR079W SEC14
SGTC_2682 pyrogallin 40.03 µM -0.646361080337694 0.262218140504084 no 2479 0.259022769706304 807 822798 An ATP competetive kinase inhibitor.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.647790086827082 0.261723347857058 no 2480 0.258560363966187 842 5282309
SGTC_1263 0774-1208 64.8 µM -0.647986953784502 0.261655220352185 no 2481 0.258496694197818 839 906585
SGTC_1154 4088-0362 150 µM -0.649990180986581 0.260962504160053 no 2482 0.257849282085918 814 6618304
SGTC_346 4513-0042 7.16 µM -0.650009896873626 0.260955691093569 no 2483 0.257842914399518 805 2827372
SGTC_534 k292-0788 63.4 µM -0.651288691096807 0.260513983523196 no 2484 0.257430073587575 833 4146317
SGTC_3160 9100216 49.47 µM -0.651831514891769 0.260326603529254 no 2485 0.257254934413153 811 17191039
SGTC_945 3381-0768 11.3 µM -0.654949209756367 0.259251737474791 no 2486 0.256250227716074 826 1126236 YIL048W NEO1
SGTC_2120 5538279 151.968 µM -0.655599620036729 0.259027789538026 no 2487 0.256040885032899 806 2058197
SGTC_1010 4112-3296 15.2 µM -0.655883324033275 0.258930136504381 no 2488 0.255949599304972 819 704384
SGTC_2729 fluphenazine 10.66 µM -0.656918374420719 0.258574025986059 no 2489 0.255616701419742 825 3372 An atypical antipsychotic.
SGTC_959 1222-0044 107 µM -0.658426038786825 0.258055766104529 no 2490 0.25513220405011 809 6083612
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.66036027987776 0.257391660175451 no 2491 0.254511327644796 821 4213774
SGTC_653 0203-0016 55.2 µM -0.66079678773076 0.257241911672298 no 2492 0.254371321567823 825 295302
SGTC_773 4358-1457 44.6 µM -0.66220005502963 0.25676081341229 no 2493 0.253921509476207 849 1186886
SGTC_1206 3978-0017 132 µM -0.662812615921256 0.256550949070455 no 2494 0.253725286334819 814 3873677
SGTC_489 paxilline 115 µM -0.663989681306816 0.256147935521154 no 2495 0.253348457693832 825 105008 A toxic potassium channel blocker.
SGTC_2794 7785382 27.27 µM -0.664078426563065 0.256117563563253 no 2496 0.253320058497959 820 2205081
SGTC_1885 st057546 99.9 µM -0.665803765008356 0.255527461392087 no 2497 0.252768269028532 810 702008
SGTC_2741 miltefosine 3.04 µM -0.666651815701402 0.255237670728622 no 2498 0.252497281681642 806 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.667857707770131 0.25482589679107 no 2499 0.252112212945924 826 676296 Flavone; oxidizing agent.
SGTC_3003 9075612 71.4286 µM -0.667905863959341 0.25480946020171 no 2500 0.252096842015405 836 6501993
SGTC_1379 2144-0755 36.5 µM -0.668528744153091 0.254596909808451 no 2501 0.25189807000928 833 5392327
SGTC_2902 5787006 60.46 µM -0.669562899177779 0.254244222013579 no 2502 0.25156823575866 818 591003
SGTC_813 k007-0158 173 µM -0.671633524115156 0.253538827648769 no 2503 0.250908515344365 828 6523916
SGTC_2667 digitoxin 100 µM -0.672027559459893 0.253404709207963 no 2504 0.25078307579834 799 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3266 9136860 49.47 µM -0.672449638290413 0.253261086934878 no 2505 0.250648745565208 822 4871271 YPR165W RHO1
SGTC_68 0986-0284 82.829 µM -0.674115626667522 0.252694613249521 no 2506 0.250118902691362 813 423278 YIL048W NEO1
SGTC_2598 perillyl alcohol 100 µM -0.674491906023097 0.252566762204489 no 2507 0.249999314929178 823 10819 An apoptosis inducer.
SGTC_1506 4226-2149 212 µM -0.67498429280295 0.252399512023056 no 2508 0.249842872159295 832 991114
SGTC_458 nppb 133 µM -0.678423954076762 0.251232784315067 no 2509 0.24875146267708 825 4549 A chloride channel blocker.
SGTC_2427 5545055 42.75 µM -0.678980019807371 0.251044435849534 no 2510 0.248575260904396 825 5372858
SGTC_798 1287-0182 476 µM -0.679007397428077 0.25103516453623 no 2511 0.24856658741519 849 1649755
SGTC_1258 0671-0043 57.1 µM -0.679338983858619 0.250922888606103 no 2512 0.248461550500784 836 4298767
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.680623153849385 0.250488316584184 no 2513 0.248054986170762 810 77254
SGTC_2040 5100729 123 µM -0.681193877325442 0.25029530789688 no 2514 0.247874410834076 830 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.681687041569773 0.250128591910395 no 2515 0.247718431553307 862 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1079 idarubicin 2.36 µM -0.683164368947954 0.249629528681912 no 2516 0.247251492423875 853 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3327 9140648 26.9345 µM -0.683467210794218 0.24952728955302 no 2517 0.247155831304467 854 8029710
SGTC_2586 curcumin 80 µM -0.684327905237232 0.249236841413379 no 2518 0.246884064850943 828 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_440 fluspirilene 35.1 µM -0.684482736447911 0.249184611483724 no 2519 0.246835193482877 839 3396 An atypical antipsychotic.
SGTC_1434 4073-0095 163 µM -0.684759746933522 0.249091180778874 no 2520 0.246747770019837 831 24133745
SGTC_186 3455-3465 67.277 µM -0.685117744111316 0.248970462315001 no 2521 0.246634812024772 831 755278
SGTC_811 0416-0114 265 µM -0.68583159318769 0.248729841750953 no 2522 0.246409655628062 829 6612453
SGTC_3152 9099253 49.47 µM -0.686418115126689 0.248532232673068 no 2523 0.246224742178481 828 25236131
SGTC_1848 st056003 16.4 µM -0.686529394705852 0.248494750159399 no 2524 0.246189667336379 817 146492
SGTC_750 4073-0104 132 µM -0.686642821493251 0.248456547497637 no 2525 0.246153918461081 809 22330957
SGTC_3215 9129942 49.47 µM -0.686716223971222 0.248431826874889 no 2526 0.246130785585801 841 17682944
SGTC_1397 3532-0190 20.1 µM -0.687075101792041 0.248310982210634 no 2527 0.246017701616185 805 5322280
SGTC_2049 5262831 67.185 µM -0.68724691763569 0.24825313788343 no 2528 0.245963571561759 832 763417
SGTC_529 4076-0302 30.3 µM -0.687698174018782 0.24810125001703 no 2529 0.245821435061317 837 5816522
SGTC_1039 k821-0043 94 µM -0.688446445612211 0.247849499434502 no 2530 0.245585842068933 813 15992768
SGTC_1996 st072960 66.8 µM -0.689341418642758 0.247548571388456 no 2531 0.245304219544406 819 1719405
SGTC_1471 k673-0312 37 µM -0.68987598493958 0.247368920594982 no 2532 0.245136089603578 822 24099884
SGTC_1050 3232-1156 69.3 µM -0.690207877195052 0.247257417199122 no 2533 0.24503173519135 836 700529
SGTC_1916 st067606 49.2 µM -0.690578050045807 0.247133084662292 no 2534 0.24491537269321 814 19590279
SGTC_1856 st057054 55.7 µM -0.691778265762959 0.246730189925269 no 2535 0.244538293813192 847 1266018
SGTC_3307 9126885 69.2785 µM -0.69208038785201 0.246628827426958 no 2536 0.244443423619769 820 24824909
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.694562978609627 0.24579675910538 no 2537 0.243664609962667 844 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1519 esterone 74 µM -0.694894071980308 0.245685903427351 no 2538 0.243560843997878 838 698 A steroid.
SGTC_1632 st005650 90 µM -0.695759630098483 0.245396226762843 no 2539 0.243289687467238 831 2759605
SGTC_2834 9001755 58.44 µM -0.696999620374211 0.244981558779407 no 2540 0.242901515692911 832 2989575
SGTC_2103 5378138 10 µM -0.697097965644664 0.244948687055805 no 2541 0.242870743624418 829 244142
SGTC_3128 9127691 49.47 µM -0.697401776081954 0.244847153974591 no 2542 0.242775695178469 839 41316314
SGTC_829 1635-0120 117 µM -0.697410853566358 0.244844120638816 no 2543 0.242772855556911 838 285054
SGTC_3081 9117243 49.47 µM -0.697924181119064 0.244672619817052 no 2544 0.242612305524165 835 45595589
SGTC_1518 st038567 90.8 µM -0.699032220599837 0.244302648570669 no 2545 0.242265947482958 861 77966
SGTC_1365 1672-3266 55.4 µM -0.699521026282325 0.244139533641413 no 2546 0.242113238720076 830 6415873
SGTC_2177 5811945 192 µM -0.699675475174521 0.244088006109298 no 2547 0.242064997885304 828 5343475
SGTC_1603 st002045 67.8 µM -0.699750035904285 0.244063133116705 no 2548 0.242041711323339 844 5887985
SGTC_1082 camptothecin 424.86 nM -0.701626150413673 0.243437723270704 no 2549 0.241456169473829 845 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_365 0121-0052 13.6 µM -0.703783674044014 0.242719576377891 no 2550 0.240783751153509 799 3101739
SGTC_2777 climbazole 1.536 µM -0.703899037136471 0.242681209288714 no 2551 0.240747825571957 841 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1027 k015-0025 8.67 µM -0.705674434132878 0.242091167708993 no 2552 0.240195311685915 839 3598955
SGTC_270 tamoxifen 5.46 µM -0.706760400379083 0.241730637721397 no 2553 0.239857693597365 859 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_183 3914-0051 30.55 µM -0.707660796855686 0.24143193616687 no 2554 0.239577964051042 819 1596232
SGTC_1759 st043059 70 µM -0.707856188869955 0.241367142431411 no 2555 0.239517284406653 859 669426
SGTC_3012 9080433 71.4286 µM -0.708468651577046 0.241164105564084 no 2556 0.239327136446552 848 17688859
SGTC_2181 6316240 54.2555 µM -0.709137250644782 0.240942565028975 no 2557 0.239119654314492 848 12779990
SGTC_2685 mycophenolic acid 18.85 µM -0.709931028243269 0.240679690328955 no 2558 0.238873454016137 823 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1945 st075991 56.6 µM -0.713776775916607 0.239408310176305 no 2559 0.237682611311888 839 1084980
SGTC_370 0180-0345 38.7 µM -0.715764212335534 0.238752716444057 no 2560 0.237068476902369 824 3989527
SGTC_164 4100-3994 89.624 µM -0.716050484397067 0.238658365147076 no 2561 0.236980088353624 860 4615967
SGTC_2994 9053520 71.4286 µM -0.717296008183229 0.238248095405096 no 2562 0.236595734894156 836 4647384
SGTC_2010 4012422 159 µM -0.717722453932805 0.23810771499797 no 2563 0.236464217795033 844 952393
SGTC_2347 9049783 174.81 µM -0.719041655597255 0.237673738071919 no 2564 0.236057627075506 870 6467988 YPL169C MEX67
SGTC_1155 4088-0394 48.2 µM -0.719248833819179 0.237605622234902 no 2565 0.235993807758255 850 2326248
SGTC_1135 dihydrocapsaicin 536.708 nM -0.720740805567109 0.237115409822028 no 2566 0.235534500682462 863 107982 A Capsaicinoid.
SGTC_349 k015-0014 24 µM -0.721763521335924 0.236779700633659 no 2567 0.235219940319527 847 2196908
SGTC_916 4466-0038 42 nM -0.72302889911524 0.236364699012145 no 2568 0.234831064800862 854 5722064 YGL116W CDC20
SGTC_1239 0337-0584 35.4 µM -0.724518148760403 0.235876788309904 no 2569 0.234373844632347 865 914301 YML130C ERO1
SGTC_2814 7977482 42.97 µM -0.724559213298427 0.235863342540508 no 2570 0.234361244236324 834 6456762
SGTC_160 3453-0671 289.699 µM -0.725687438794869 0.235494092770582 no 2571 0.234015201998263 860 5322268
SGTC_3187 9109394 49.47 µM -0.726456671549742 0.235242518448717 no 2572 0.233779430116154 838 17098090
SGTC_66 0109-0187 42.4 µM -0.726881360864043 0.235103689206731 no 2573 0.233649318143203 832 759417
SGTC_2087 5276107 200 µM -0.726905799419755 0.235095701717623 no 2574 0.233641832130056 839 144405
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.727208908409233 0.234996646139922 no 2575 0.233548994903357 852 5377381
SGTC_2296 7971656 126.45 µM -0.727468504935857 0.234911828706684 no 2576 0.233469501084105 834 666570
SGTC_1540 guanosine 70.6 µM -0.727756558597366 0.234817733337215 no 2577 0.23338131067168 847 6802 Guanosine is a purine nucleoside
SGTC_381 3461-2219 42.7 µM -0.728521023880804 0.23456811478587 no 2578 0.233147351874545 861 2883159
SGTC_1300 1094-0077 113 µM -0.730084461637908 0.234058067479938 no 2579 0.232669279305072 850 5532636
SGTC_474 dl-dihydrosphingosine 5 µM -0.732038570290687 0.233421434426785 no 2580 0.23207251313662 821 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_627 1391-0720 175 µM -0.73263647959625 0.233226832438451 no 2581 0.231890087719865 877 997839
SGTC_2122 5258151 111.688 µM -0.733422629214891 0.232971100827916 no 2582 0.231650350736469 844 2173356
SGTC_1751 st044839 27.194 µM -0.734060866796455 0.232763599060125 no 2583 0.231455821283353 825 5291326
SGTC_237 nikkomycin 200 µM -0.734396111062025 0.232654646667961 no 2584 0.231353678145204 863 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_404 fumagillin 50 µM -0.734772660211479 0.232532304243729 no 2585 0.231238980105194 846 12015870 A methionine aminopeptidase binder.
SGTC_631 k072-0230 41.5 µM -0.73507575079122 0.232433854812487 no 2586 0.231146680822041 862 5773147
SGTC_2966 9084041 48.03 µM -0.735134534845699 0.232414763347794 no 2587 0.231128781867295 837 17741380
SGTC_747 3448-8087 38.7 µM -0.736470296585457 0.231981179365587 no 2588 0.230722268897334 868 5168703
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.737083499349318 0.231782286653144 no 2589 0.230535786469259 809 4000243
SGTC_834 0312-0008 75.7 µM -0.737345740554005 0.231697257558723 no 2590 0.230456061448254 858 6385573 YIL048W NEO1
SGTC_2121 5257820 149.641 µM -0.737496074399198 0.231648521148416 no 2591 0.230410364792149 824 791256
SGTC_2084 5306078 60.6385 µM -0.737915103269439 0.231512707227716 no 2592 0.230283020228044 882 679340
SGTC_3211 9128781 49.47 µM -0.738656152251632 0.231272630173916 no 2593 0.230057908837621 855 17194361
SGTC_620 0109-0052 432 µM -0.741194083621872 0.230451471714641 no 2594 0.229287885084716 866 493037
SGTC_797 k781-0471 270 µM -0.741333956420045 0.230406262714516 no 2595 0.229245488885468 846 23738129
SGTC_2859 9028643 45.46 µM -0.741449140390776 0.230369037239229 no 2596 0.229210579303442 816 17151580
SGTC_528 3492-0019 172 µM -0.743481570738561 0.229712744187271 no 2597 0.22859508754282 853 2869262
SGTC_729 4092-0585 94.1 µM -0.743692334405116 0.229644746366903 no 2598 0.228531314018178 843 2169061
SGTC_2236 dapsone 200 µM -0.74423606357505 0.229469377319996 no 2599 0.228366836915001 832 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3042 9091578 49.47 µM -0.744777059378082 0.229294964375562 no 2600 0.228203252693759 842 25236497
SGTC_2851 9015922 71.43 µM -0.745034549582115 0.229211977599 no 2601 0.228125416945598 853 2996893
SGTC_1466 k213-0079 57.5 µM -0.745201031798639 0.229158330844572 no 2602 0.228075099608012 875 3657981
SGTC_447 ml7 120 µM -0.745793506481277 0.228967470627358 no 2603 0.227896081580429 864 4216 Selective myosin light chain kinase inhibitor.
SGTC_1120 ficusin 1.78878 µM -0.745854945100305 0.228947683852355 no 2604 0.227877522239979 874 6199 A DNA cross-linker.
SGTC_1984 st072354 53.1 µM -0.746982480289937 0.228584722992888 no 2605 0.227537068152756 847 5762938
SGTC_3064 1327-0027 10 µM -0.748292098267065 0.228163554492401 no 2606 0.227141994808126 823 16000455 YPR107C YTH1
SGTC_2793 7325131 81.82 µM -0.748304636204871 0.228159524445715 no 2607 0.22713821434956 837 4176441
SGTC_3278 9139605 49.47 µM -0.74956472238028 0.227754701419447 no 2608 0.226758452155541 861 7958859
SGTC_1478 0453-0656 35.7 µM -0.750132564654769 0.227572405142918 no 2609 0.22658743418169 863 5258496
SGTC_402 epigallocatechin gallate 10 µM -0.753653896139278 0.226443776792752 no 2610 0.225528536220551 853 65064 An antioxidant.
SGTC_585 0kpi-0023 191 µM -0.755110475469539 0.225977851632626 no 2611 0.225091349129761 828 64601
SGTC_2391 6285546 200 µM -0.757032020992067 0.225364024758141 no 2612 0.224515339352157 853 846083
SGTC_284 0988-0104 32.6 µM -0.758813587476739 0.224795757787694 no 2613 0.223982038227874 867 4666532
SGTC_180 1486-1293 102.781 µM -0.758955240682696 0.224750609503551 no 2614 0.223939666110007 854 4140536
SGTC_3338 9144300 39.5675 µM -0.759108662375923 0.224701716120555 no 2615 0.223893778873362 848 4901274
SGTC_1913 st060213 96.1 µM -0.761327986568043 0.22399512315618 no 2616 0.223230594235229 869 688959
SGTC_2933 9026794 32.47 µM -0.762664450526614 0.22357022674729 no 2617 0.222831768373348 860 17586027
SGTC_1636 st007707 68.9 µM -0.764758138634306 0.222905511673767 no 2618 0.222207789597595 877 403051
SGTC_2351 9026858 72.31 µM -0.765462619245129 0.222682102880198 no 2619 0.22199805868902 893 1409300
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.765698623662054 0.222607288401653 no 2620 0.221927823100433 880 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_137 0438-0332 85.389 µM -0.766005282514075 0.222510097554323 no 2621 0.221836579509225 873 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2985 9022375 71.43 µM -0.768219528924375 0.221809044445128 no 2622 0.221178386599174 870 4939335
SGTC_2551 apiole 73.87 µM -0.771774209188331 0.220686239026394 no 2623 0.220124084761448 846 10659 A possible DNA adduct former.
SGTC_846 0335-0850 148 µM -0.772983786500914 0.220304917384764 no 2624 0.219765988071653 849 6819598
SGTC_553 k007-0256 45.7 µM -0.774338522654814 0.219878282943865 no 2625 0.219365314268007 865 6287000
SGTC_3065 9113888 49.47 µM -0.774974947454601 0.219678023422399 no 2626 0.219177231674026 852 16648368
SGTC_1486 3970-0793 4.53 µM -0.777159315827366 0.218991480013018 no 2627 0.218532390991269 876 2844330
SGTC_2624 nerol 100 µM -0.778474276065379 0.218578785901096 no 2628 0.218144732931731 878 637566 A natural product oil.
SGTC_2634 4'-methoxyflavone 100 µM -0.77878064928082 0.218482696457677 no 2629 0.218054469255806 862 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_725 1497-0963 19 µM -0.779616940740683 0.218220529827175 no 2630 0.217808190693399 852 3549977
SGTC_2576 guaiol 23.12 µM -0.780477566194424 0.217950924160936 no 2631 0.217554913632325 841 227829
SGTC_3002 9075603 71.4286 µM -0.780784702831681 0.217854754869339 no 2632 0.217464566280878 866 20105405
SGTC_667 1498-1044 59 µM -0.783452806249134 0.217020360258845 no 2633 0.21668062850714 890 6739982
SGTC_310 1273-0058 1.06 µM -0.785033359941585 0.216526946831932 no 2634 0.216217004764899 830 2734232
SGTC_3089 9117425 49.47 µM -0.785742817605003 0.216305681285295 no 2635 0.216009086497439 876 9401657
SGTC_1292 0kpi-0043 232 µM -0.785819335910814 0.21628182459037 no 2636 0.215986668468012 857 3333905
SGTC_961 1252-1571 372 µM -0.785952460403285 0.216240322984142 no 2637 0.215947669395344 878 6813498
SGTC_541 4513-1321 94 µM -0.786827246900929 0.215967722714876 no 2638 0.215691500542735 848 747515
SGTC_749 1000-0129 128 µM -0.787229952860901 0.215842298759009 no 2639 0.215573633041406 883 708470
SGTC_1515 3460-0031 42.1 µM -0.788591689441608 0.215418494737157 no 2640 0.215175344879489 858 2876596
SGTC_1561 5-methoxyflavone 52.9 µM -0.790211841429151 0.214914895239131 no 2641 0.214702030841994 854 94525
SGTC_2516 gossypol 71.55 µM -0.790873642491309 0.214709381357635 no 2642 0.214508865300936 888 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1568 digitonin 820 nM -0.792305598971468 0.214265096618263 no 2643 0.214091253904222 884 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1496 4469-0713 57.4 µM -0.792574287391068 0.214181791866319 no 2644 0.214012947189888 879 746691
SGTC_1360 1598-0022 39.8 µM -0.793005771530581 0.21404805300723 no 2645 0.213887230082698 876 761525
SGTC_2773 thioridazine 9.09 µM -0.793791289694229 0.213804705839563 no 2646 0.213658472140353 877 5452 An antipsychotic.
SGTC_363 0455-0021 3.06 µM -0.795711763539439 0.213210437500689 no 2647 0.213099793935852 857 4597466
SGTC_104 0074-0074 590.992 µM -0.797794446157756 0.212567065586695 no 2648 0.212494892391719 859 3943124
SGTC_2196 6573537 42.6665 µM -0.798320544249887 0.212404725565752 no 2649 0.212342249483232 884 2903087
SGTC_3071 9117417 49.47 µM -0.798568863868494 0.212328125841385 no 2650 0.212270223913276 878 45595590 YGL055W OLE1
SGTC_576 1073-0113 22.7 µM -0.798572723167506 0.212326935481948 no 2651 0.212269104629075 894 5439563
SGTC_2767 sibutramine 71.45 µM -0.798724134879728 0.212280237239355 no 2652 0.212225194522692 857 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1322 1348-1070 12 µM -0.800253146872836 0.211808997441964 no 2653 0.211782071498771 852 6758089
SGTC_756 0508-1999 28.3 µM -0.800602358487312 0.21170145673516 no 2654 0.211680942465865 887 6753853
SGTC_1788 fluconazole 20 µM -0.800899451233423 0.21160999134463 no 2655 0.211594928917224 860 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3301 9125354 19.7965 µM -0.801978659511631 0.211277932203726 no 2656 0.211282651439187 845 41905162
SGTC_2258 7960471 200 µM -0.80281294466063 0.211021442240107 no 2657 0.211041429554309 872 2974708
SGTC_2669 eugenol 100 µM -0.802892778906505 0.210996907826995 no 2658 0.21101835506458 848 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_211 3455-0679 143.504 µM -0.802996948700271 0.210964897203355 no 2659 0.210988249096123 859 748649
SGTC_1841 st054148 70 µM -0.80421073118271 0.210592120547685 no 2660 0.210637641141593 887 675442
SGTC_1264 0783-0040 158 µM -0.80461794615502 0.210467143401128 no 2661 0.210520091410931 872 2855798
SGTC_616 4092-0450 108 µM -0.804786609312397 0.210415392241206 no 2662 0.210471415115596 895 787165
SGTC_892 0929-0076 29 µM -0.806238387546316 0.209970249998291 no 2663 0.210052704219779 870 5751038
SGTC_2582 agaric acid 100 µM -0.807160506587389 0.209687798733662 no 2664 0.209787007958226 859 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_880 0833-0487 87.2 µM -0.809181039920563 0.209069677493777 no 2665 0.209205509575763 879 76075
SGTC_2801 7907800 81.82 µM -0.809501739927693 0.208971667762264 no 2666 0.209113301210911 872 6620925
SGTC_2076 5212012 200 µM -0.809908650480686 0.208847350025301 no 2667 0.208996339853392 867 604802
SGTC_2853 9015042 58.44 µM -0.81180464395361 0.208268668243343 no 2668 0.208451868459467 858 6457456
SGTC_893 0958-0369 48.9 µM -0.811853675635082 0.208253715697853 no 2669 0.208437799163609 871 6819948
SGTC_816 0325-0417 81.3 µM -0.812136601446449 0.208167447915645 no 2670 0.208356626533252 863 68101
SGTC_3287 9117173 37.0625 µM -0.812163459312275 0.208159259697014 no 2671 0.208348921865372 835 2789709
SGTC_594 1487-1584 10.8 µM -0.813842649206341 0.207647698780023 no 2672 0.207867549463877 900 5013332
SGTC_3133 9127736 49.47 µM -0.815281008836594 0.207210097390153 no 2673 0.207455738446375 856 27243420
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.816547543569886 0.206825223352248 no 2674 0.207093521516882 872 23665772 A membrane-active detergent.
SGTC_732 3970-1727 52.7 µM -0.817567874715751 0.206515473554243 no 2675 0.206801988778734 868 1275699
SGTC_765 1319-0117 244 µM -0.817581594884007 0.206511310290229 no 2676 0.206798070258351 855 3487746 YGL099W LSG1
SGTC_2786 7743617 45.45 µM -0.817759879624008 0.206457215879511 no 2677 0.206747155609227 873 583674
SGTC_1087 pterostilbene 9.05 µM -0.81821577558348 0.206318928018765 no 2678 0.206616994361977 891 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2843 9000894 45.46 µM -0.819072167272473 0.206059305426368 no 2679 0.206372620241216 806 2242070
SGTC_2171 5739187 198.077 µM -0.820241476851516 0.205705132074799 no 2680 0.206039230718134 860 2262761
SGTC_2518 prenyletin 46.28 µM -0.822037918413484 0.20516171053964 no 2681 0.20552765822665 853 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2254 7938975 95.19 µM -0.822359474056595 0.205064530413924 no 2682 0.205436168497203 881 2969277
SGTC_1469 k284-2957 126 µM -0.822875355082633 0.20490867869461 no 2683 0.205289439412236 852 23884841
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.824475507445656 0.204425708288693 no 2684 0.204834713450758 885 6708561
SGTC_2940 9060638 45.86 µM -0.824770935470043 0.204336614065221 no 2685 0.204750825249762 864 4027022
SGTC_2847 9005661 71.43 µM -0.827050448937744 0.203649943494186 no 2686 0.204104233911072 848 2991449
SGTC_3010 9080089 71.4286 µM -0.828897870660301 0.203094445098601 no 2687 0.203581100196404 867 17027233
SGTC_2781 5567276 71.43 µM -0.829947903147353 0.20277911606892 no 2688 0.203284119639253 900 2853274
SGTC_2183 6420625 130.508 µM -0.831102704430377 0.202432662508934 no 2689 0.20295780604379 888 2897619
SGTC_2852 9023854 51.95 µM -0.831609790469687 0.202280642810962 no 2690 0.202814617027403 887 19798528
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.832192995797903 0.202105887711973 no 2691 0.202650008381221 896 521171
SGTC_2863 9028737 58.44 µM -0.833619751544126 0.201678747190406 no 2692 0.20224764590517 876 6460917
SGTC_2780 5215298 71.43 µM -0.835055777174799 0.201249377916365 no 2693 0.201843152154738 908 2834131
SGTC_269 exalamide 29 µM -0.835795994815345 0.201028268298675 no 2694 0.201634840040087 887 3316 A derivative of salicylamide.
SGTC_1621 st003705 32.4 µM -0.836215035811739 0.200903161634359 no 2695 0.201516970595242 873 24207032
SGTC_2480 5767542 37.17 µM -0.840107401785239 0.199743311275303 no 2696 0.2004240851929 869 2867358
SGTC_3181 9108277 49.47 µM -0.84014845810072 0.199731098789492 no 2697 0.200412576545853 906 17097298
SGTC_2027 5150920 200 µM -0.840702458374492 0.199566351495565 no 2698 0.200257321508263 862 786715
SGTC_2946 9065502 71.43 µM -0.841264573280541 0.19939927470743 no 2699 0.200099866286094 828 16489101
SGTC_1350 1495-0454 146 µM -0.843825063557029 0.198639289107626 no 2700 0.199383583862598 870 1069057
SGTC_3214 9129694 49.47 µM -0.844822135852232 0.198343818752532 no 2701 0.199105076759337 895 17158655
SGTC_3148 9097893 49.47 µM -0.84502047332139 0.198285075477481 no 2702 0.199049704129223 852 17174100
SGTC_205 1486-1330 71.903 µM -0.845267165136457 0.198212025344012 no 2703 0.198980844692779 887 4118834
SGTC_478 N-arachidonylglycine 10 µM -0.84659140340066 0.197820170976983 no 2704 0.198611453602813 855 5283389
SGTC_3230 9131665 49.47 µM -0.850293353782531 0.196727215309087 no 2705 0.197581005372199 869 15943720
SGTC_1968 st069590 43.6 µM -0.850355193162914 0.196708989098918 no 2706 0.197563819697573 881 6384066
SGTC_2894 9048625 32.47 µM -0.850468542033088 0.196675583911149 no 2707 0.197532321456551 880 4092861
SGTC_2572 astragaloside iv 100 µM -0.851456241855346 0.196384643108869 no 2708 0.197257980475993 882 45006101 An anti-inflammatory agent.
SGTC_1703 st026983 48.3 µM -0.853250102176829 0.195856904035081 no 2709 0.196760312248037 869 1104023
SGTC_411 enrofloxacin 100 µM -0.856004312088128 0.195048314889389 no 2710 0.195997697148812 878 71188 A bacterial gyrase inhibitor.
SGTC_591 4299-0174 154 µM -0.856688250645379 0.194847837152426 no 2711 0.1958085992111 898 5509088
SGTC_3076 9116187 49.47 µM -0.857451155933574 0.194624360416454 no 2712 0.195597798937415 882 27241210
SGTC_684 1140-0066 328 µM -0.858099869051171 0.194434456572663 no 2713 0.195418659832114 878 6813534
SGTC_394 menadione 8.33 µM -0.858544524266881 0.194304353682156 no 2714 0.19529592795027 892 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1769 st044406 64.4 µM -0.858685793429659 0.194263030448515 no 2715 0.195256945229235 912 670903
SGTC_1824 st053723 68.6 µM -0.859166925483283 0.194122332656385 no 2716 0.195124214034483 883 675225
SGTC_2736 butenafine 14.65 µM -0.860151647976693 0.193834563150423 no 2717 0.194852727027852 884 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_58 0957-0393 9 µM -0.860174319626633 0.193827940784614 no 2718 0.194846479183315 888 6997992
SGTC_3039 9090270 49.47 µM -0.860294986651809 0.19379269639016 no 2719 0.194813227861118 853 17173750
SGTC_1630 st005209 31.3 µM -0.860465154012047 0.193743000590074 no 2720 0.194766341962621 858 3367314
SGTC_347 4534-1311 26.2 µM -0.860556305182918 0.193716383931435 no 2721 0.194741230072213 899 2862016
SGTC_1261 0712-0010 12.7 µM -0.860603355662548 0.193702645797103 no 2722 0.194728268568589 896 2840123
SGTC_1132 3456-3614 2.5 µM -0.862080253063685 0.19327171280506 no 2723 0.194321678527756 910 3125502
SGTC_1133 3473-0247 50 µM -0.862152371148631 0.193250684995057 no 2724 0.194301837655941 871 711311
SGTC_1917 st066507 28.5 µM -0.862631105719444 0.193111133501592 no 2725 0.194170161173848 884 3156428
SGTC_3202 9113761 49.47 µM -0.865265762835687 0.192344230472095 no 2726 0.193446468896498 896 4798415
SGTC_1590 st077108 57.8 µM -0.865550950802501 0.192261329058446 no 2727 0.193368231781643 876 5489485
SGTC_2471 5466956 24.79 µM -0.868426352738163 0.19142669875924 no 2728 0.192580486754986 881 724419
SGTC_3125 9127534 49.47 µM -0.870015254827148 0.190966449000154 no 2729 0.192146033834794 871 1639235
SGTC_2201 6605497 169.863 µM -0.870219260783044 0.190907404767305 no 2730 0.19209029603023 895 670741
SGTC_1070 indatraline 8.81 µM -0.870893908061164 0.190712225379237 no 2731 0.191906041690879 896 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_964 1287-0107 19.4 µM -0.872082413841052 0.190368681772947 no 2732 0.191581709654309 889 51516812 YPR165W RHO1
SGTC_1689 st020265 53.493 µM -0.872349808933091 0.190291442277269 no 2733 0.191508786347026 903 5758320 YPR016C TIF6
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.872350839833055 0.190291144529728 no 2734 0.19150850523553 893 551469
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.872513155173803 0.190244267708621 no 2735 0.191464247345453 905 23847180
SGTC_125 0133-0007 11.75 µM -0.872725835166846 0.190182856267994 no 2736 0.191406266208622 878 26541
SGTC_1382 3002-2117 298 µM -0.87472502568669 0.189606184678508 no 2737 0.190861769988164 940 1497314
SGTC_245 methotrexate 289.6 µM -0.87585846778246 0.189279718769926 no 2738 0.190553490124855 874 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1252 0493-0875 34.8 µM -0.879278190788399 0.188296833116961 no 2739 0.189625228976685 884 3960963
SGTC_2130 NSC 7 2.4545 µM -0.88083444062278 0.187850585298691 no 2740 0.189203717865385 889 21448
SGTC_2978 9011784 42.97 µM -0.88095676557234 0.187815536861794 no 2741 0.189170610560159 879 2994934
SGTC_1482 3346-2049 8.48 µM -0.88149461931878 0.187661479401127 no 2742 0.189025082520566 889 3826804
SGTC_997 3996-0078 137 µM -0.882319420750246 0.187425383211772 no 2743 0.188802048541413 884 735687
SGTC_1125 tnp00248 1.32998 µM -0.883354558600816 0.1871293389668 no 2744 0.188522367233879 900 24207736
SGTC_2374 9071832 200 µM -0.883508502769891 0.187085336421917 no 2745 0.18848079527685 876 17381698
SGTC_1181 1222-0449 220 µM -0.884215116579705 0.186883443982301 no 2746 0.188290049812536 912 658318
SGTC_2281 7943571 200 µM -0.884476011940626 0.186808935516355 no 2747 0.188219653045552 902 1244024
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.885251080128357 0.186587694156817 no 2748 0.188010614069375 872 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_145 3737-0113 38.366 µM -0.88852960001726 0.185653644332065 no 2749 0.18712797048298 883 6849351
SGTC_3248 9135562 49.47 µM -0.890669094831989 0.185045669752596 no 2750 0.186553359684273 899 17650701
SGTC_2861 9024595 19.48 µM -0.892408649717626 0.184552257841765 no 2751 0.186086968278951 862 16482810
SGTC_181 1447-1644 8.07 µM -0.892994780731704 0.184386190565339 no 2752 0.185929983849367 932 534600
SGTC_320 4092-0846 5.34 µM -0.893509159494211 0.184240529322741 no 2753 0.185792284619948 883 1359356
SGTC_3347 9188721 44.724 µM -0.898824968847011 0.182739400729885 no 2754 0.184372949113572 900 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1351 1496-0003 46.5 µM -0.899674536267193 0.182500201465779 no 2755 0.184146739128628 910 3891978
SGTC_2441 5730946 39.09 µM -0.900092578553183 0.182382571736489 no 2756 0.184035492585559 869 1774275
SGTC_1147 3809-1045 12.3 µM -0.90022884307474 0.182344239541381 no 2757 0.183999239850727 880 325925
SGTC_2844 9010103 25.97 µM -0.901985239936308 0.181850603105417 no 2758 0.183532354257938 901 2480525
SGTC_1558 st069300 45.6 µM -0.902937160405388 0.181583414867133 no 2759 0.183279623470403 883 24208000
SGTC_3059 1327-0034 3 µM -0.903439344778871 0.181442559113107 no 2760 0.183146383167703 888 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2820 7989630 71.43 µM -0.906113473048841 0.180693655594355 no 2761 0.182437897405298 844 2984098
SGTC_2971 9092186 9.93 µM -0.908050967074763 0.180152262963476 no 2762 0.181925647275795 893 25236400
SGTC_1696 st025591 34.7925 µM -0.909635010066842 0.179710392286258 no 2763 0.181507514355491 889 2787147
SGTC_3194 9111903 49.47 µM -0.909751224240151 0.179678001038245 no 2764 0.181476861510088 905 17087251
SGTC_876 0720-0963 56.8 µM -0.909871273700292 0.179644544670243 no 2765 0.181445200465812 915 765861
SGTC_791 1348-1292 225 µM -0.912440361315783 0.178929508747432 no 2766 0.180768475416348 924 5437054
SGTC_2899 9053889 58.44 µM -0.912809549924514 0.178826902487802 no 2767 0.180671357394473 895 6470052
SGTC_2879 9041815 71.43 µM -0.914232311580175 0.178431829807405 no 2768 0.180297394605712 886 4942971
SGTC_1363 1636-0063 10.4 µM -0.91777220252508 0.177451260504512 no 2769 0.179369069023244 891 6072185
SGTC_652 0437-0092 114 µM -0.918583918150474 0.177226891152225 no 2770 0.179156623402967 900 3091274
SGTC_2485 5633444 17.78 µM -0.920149250119624 0.17679471805072 no 2771 0.178747385280018 900 5724239
SGTC_2190 6049624 200 µM -0.920734135768048 0.176633407856086 no 2772 0.17859462477552 886 2265554
SGTC_596 1155-0152 116 µM -0.921028248408147 0.176552327405402 no 2773 0.178517839476346 904 280313
SGTC_2367 9070478 135.38 µM -0.923084928744663 0.175986003411622 no 2774 0.177981474026082 895 572802
SGTC_2740 felodipine 17.08 µM -0.923684276468468 0.175821184722446 no 2775 0.177825360442953 884 3333 L-type calcium channel blocker
SGTC_2271 7849410 118.62 µM -0.923823762164466 0.17578284063589 no 2776 0.177789040652621 926 972430
SGTC_2915 7971052 15.16 µM -0.926317770231441 0.175098141585366 no 2777 0.177140431808842 868 5741558
SGTC_2737 bleomycin 30.5 nM -0.928010330528744 0.174634435111861 no 2778 0.176701105475871 912 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2959 9079155 11 µM -0.928878079529687 0.174397002744291 no 2779 0.176476137144022 898 16189457
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.929061697073178 0.174346787847969 no 2780 0.176428556598683 886 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2750 bromebric acid 70.15 µM -0.930643708506842 0.173914527093147 no 2781 0.17601894851713 922 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1243 0416-0003 5.65 µM -0.932678798354284 0.173359472638369 no 2782 0.175492917411892 913 2141977
SGTC_2545 solidagenone 89.61 µM -0.933163737836051 0.17322737584626 no 2783 0.17536771715349 848 6708572 An anti ulcer agent
SGTC_1432 4049-0298 68.4 µM -0.933265788912228 0.173199585450917 no 2784 0.175341377119039 911 741646
SGTC_366 0181-0206 4.31 µM -0.93548016938085 0.172597268005916 no 2785 0.17477044920647 927 274874
SGTC_973 1325-0077 65.9 µM -0.935810281883577 0.172507591044182 no 2786 0.174685438348783 921 2835149
SGTC_1251 0490-5699 265 µM -0.936802593770016 0.172238202755916 no 2787 0.17443005543322 907 3883818
SGTC_89 0302-0250 142.109 µM -0.937662033816486 0.172005102948916 no 2788 0.17420906037805 936 4203518 YLR208W SEC13
SGTC_1227 3909-8010 46.6 µM -0.938970668300355 0.171650558315605 no 2789 0.173872902083166 914 15982272
SGTC_656 4090-1979 187 µM -0.942396883890074 0.170724516598257 no 2790 0.172994741009842 900 22330961
SGTC_2123 5259487 200 µM -0.943177192682089 0.170514061678635 no 2791 0.172795138588908 906 2173474
SGTC_2252 omeprazole 400 µM -0.944084295320415 0.170269618442157 no 2792 0.17256328697341 896 4594 A proton pump inhibitor.
SGTC_2605 digitonin 300 nM -0.944640534084673 0.170119836022831 no 2793 0.172421212850399 905 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_383 2324-0395 7.37 µM -0.946391050026208 0.169649013183171 no 2794 0.171974584309719 868 3146421
SGTC_253 dyclonine 31.25 µM -0.947199885912154 0.169431749404199 no 2795 0.171768466752738 906 3180 An oral anasthetic.
SGTC_2346 9031566 143.75 µM -0.947636677766874 0.169314495746473 no 2796 0.171657223692164 915 4771086
SGTC_2220 6782180 200 µM -0.948588892231891 0.169059061156651 no 2797 0.17141487130211 894 833803
SGTC_3001 9076041 71.4286 µM -0.94886396057871 0.168985319284967 no 2798 0.17134490315123 911 16004211
SGTC_822 1487-0950 154 µM -0.948926054341586 0.168968675698082 no 2799 0.171329111109166 896 1958375
SGTC_62 0180-0423 3.232 µM -0.949579784563854 0.168793514017861 no 2800 0.171162907154848 922 30102 YGL099W LSG1
SGTC_3004 9076122 71.4286 µM -0.949880708786097 0.168712923058039 no 2801 0.17108643503902 938 44782551
SGTC_135 0933-0004 26.348 µM -0.950536926698775 0.168537266147404 no 2802 0.170919750008945 897 21230617 YGL099W LSG1
SGTC_1009 4106-0057 9.87 µM -0.950826115667948 0.168459893162662 no 2803 0.170846326502466 894 2928005
SGTC_764 1951-2361 146 µM -0.951776790849678 0.168205699439379 no 2804 0.170605097503504 902 5438930
SGTC_289 k017-0060 526 µM -0.952989452849612 0.167881813401364 no 2805 0.170297707325797 918 5512909
SGTC_1947 st076332 61.6 µM -0.953556915841906 0.167730389500637 no 2806 0.170153986584668 922 24208416
SGTC_1875 nocodazole 6 µM -0.95488181857345 0.167377190117456 no 2807 0.169818732573953 909 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_397 arbidol 50 µM -0.956042731473426 0.167068102249053 no 2808 0.169525323045918 916 131410 A RNA synthesis inhibitor.
SGTC_1799 st045822 46.1415 µM -0.957134301227089 0.166777812628621 no 2809 0.169249736216852 875 3674992
SGTC_882 0843-0131 351 µM -0.957934593913218 0.166565191464187 no 2810 0.169047870466578 912 5425421
SGTC_3260 9137109 49.47 µM -0.958304457112009 0.166466985627166 no 2811 0.168954628476456 897 17478346
SGTC_790 1575-0012 79.1 µM -0.958407038651658 0.166439754866029 no 2812 0.168928773668241 903 378741 YLR208W SEC13
SGTC_3090 9117696 49.47 µM -0.959247761849195 0.166216689243793 no 2813 0.168716972289334 889 7923821
SGTC_1524 corynanthine 62.1 µM -0.960001104884945 0.166016971956489 no 2814 0.168527329428941 950 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1938 st074717 56.4 µM -0.960227588263074 0.165956959723403 no 2815 0.168470342424826 863 17250979
SGTC_1381 2324-0066 62.1 µM -0.960812477943998 0.165802043957234 no 2816 0.16832323172719 909 10885928
SGTC_2941 9056145 11.23 µM -0.963876711365276 0.164991969593248 no 2817 0.16755387050553 911 2119517
SGTC_788 1182-0090 188 µM -0.964055410549456 0.164944807098944 no 2818 0.167509073108299 909 5715185
SGTC_3168 9103419 49.47 µM -0.964739125568573 0.164764440852089 no 2819 0.167337746519299 915 16649256
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.965990959842446 0.164434534144961 no 2820 0.167024352325488 884 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1205 4161-2785 76 µM -0.967318173207241 0.164085230113611 no 2821 0.166692500770555 932 3498106
SGTC_3292 9120825 59.784 µM -0.968006484499355 0.163904265870097 no 2822 0.16652056560363 898 24824900
SGTC_985 1493-0307 8.71 µM -0.968265818745181 0.1638361177848 no 2823 0.166455815492511 943 3278274
SGTC_90 0870-0863 4.608 µM -0.968650377573327 0.163735096928843 no 2824 0.166359829458793 946 1738164
SGTC_1403 3909-7815 62.9 µM -0.973941163305533 0.162349351366033 no 2825 0.165042876859867 904 6615483
SGTC_3237 9133362 49.47 µM -0.974551629466833 0.162189952699391 no 2826 0.164891358575019 932 43845137
SGTC_2150 5556613 200 µM -0.978124010883035 0.16125921279708 no 2827 0.164006496851557 938 743190
SGTC_2149 5554786 194.827 µM -0.98174828058924 0.160318521591037 no 2828 0.163111936735666 945 745063 YPR165W RHO1
SGTC_2215 7188065 200 µM -0.983622357828992 0.159833508134965 no 2829 0.16265061397854 937 940217
SGTC_3240 9133527 49.47 µM -0.984438388260868 0.159622618757508 no 2830 0.162450005482732 923 17617455
SGTC_2839 9003951 25.97 µM -0.985837143908795 0.159261557599172 no 2831 0.162106517696997 905 2990634
SGTC_862 0452-0056 10.2 µM -0.986360663952056 0.159126558896993 no 2832 0.161978080344156 933 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2819 7996655 46.38 µM -0.987024065886269 0.158955596941495 no 2833 0.161815420431311 899 6456960
SGTC_969 1313-0238 134 µM -0.987111049766724 0.158933189694608 no 2834 0.161794100697703 931 5212874
SGTC_3254 9136651 49.47 µM -0.987972730014019 0.158711330711025 no 2835 0.1615830019056 940 16454030
SGTC_3277 9138724 49.47 µM -0.988422654538218 0.158595568236384 no 2836 0.161472848502074 917 15943418
SGTC_80 0159-0065 512.242 µM -0.99101196211856 0.157930433774556 no 2837 0.160839869619116 907 1548079
SGTC_1327 1436-0082 2.18 µM -0.993573445737569 0.157274251466323 no 2838 0.160215288656075 945 15992205
SGTC_3056 9094900 49.47 µM -0.993741034810475 0.157231382275677 no 2839 0.160174479800769 928 25236784
SGTC_1270 0831-1170 17.3 µM -0.995305215237686 0.156831636336502 no 2840 0.1597939210309 916 6764716
SGTC_2188 6126565 140.678 µM -0.995665751633943 0.156739591656897 no 2841 0.159706287937512 913 874518
SGTC_1415 3966-0071 78.1 µM -0.997305093777927 0.156321517248914 no 2842 0.159308221000017 923 2893185
SGTC_2837 9008476 45.46 µM -0.998223388636735 0.156087649699638 no 2843 0.159085523741913 912 2992805
SGTC_3271 9137798 49.47 µM -0.998563803295306 0.156001012905558 no 2844 0.159003021040343 869 6498326
SGTC_182 3448-4371 550.524 µM -0.999988426315079 0.155638784987372 no 2845 0.158658054440589 906 3491403
SGTC_1030 k029-0042 36.7 µM -1.00011860686303 0.155605712666482 no 2846 0.158626556244848 928 6080581
SGTC_602 3130-1533 38.1 µM -1.0001484537298 0.155598130734101 no 2847 0.158619335141237 949 720941
SGTC_3069 9117009 49.47 µM -1.00017512726732 0.155591355121604 no 2848 0.158612881970268 916 41904981
SGTC_3162 9099653 49.47 µM -1.0023586353184 0.155037360411054 no 2849 0.15808520629496 886 25237511
SGTC_1138 3761-0006 1.03 µM -1.00254250030631 0.154990770134775 no 2850 0.158040825376029 937 12061087
SGTC_1526 st051518 75 µM -1.00335786256078 0.154784273693845 no 2851 0.157844113631342 935 673993
SGTC_1229 0139-0193 12.2 µM -1.00898386411128 0.153364403495713 no 2852 0.156491186398484 925 3090752
SGTC_121 0557-0495 61.343 µM -1.00993674800096 0.15312477525673 no 2853 0.15626279759105 952 3104427
SGTC_3017 9080681 49.47 µM -1.01055168392124 0.152970264924464 no 2854 0.156115525351035 951 16451914
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.01094305308902 0.1528719823766 no 2855 0.156021843205378 959 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_153 4077-0274 519.67 µM -1.01174368230029 0.152671054909632 no 2856 0.155830311818309 914 3121976
SGTC_185 k048-0037 25.491 µM -1.01256709752488 0.152464591837269 no 2857 0.155633491189582 922 6827589
SGTC_3253 9135987 49.47 µM -1.01327547719653 0.152287121107482 no 2858 0.155464298725189 931 4182430
SGTC_236 1509-0011 5.31 µM -1.01858657373125 0.150960899171077 no 2859 0.154199640512671 929 3107280
SGTC_857 0438-0306 1.35 µM -1.0250663028303 0.149353300809212 no 2860 0.152665952021322 917 4686136
SGTC_1481 3346-2004 36 µM -1.02518754601937 0.149323330125833 no 2861 0.152637351721048 941 2770522
SGTC_2738 aclarubicin 5.55 µM -1.02705321625897 0.148862652472355 no 2862 0.152197703195776 929 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2082 5219693 150 µM -1.02781212009003 0.148675533370017 no 2863 0.152019106960547 920 2834649
SGTC_313 3474-0040 5.03 µM -1.02934695121774 0.148297578507431 no 2864 0.151658333877689 924 1043375 YIL048W NEO1
SGTC_1091 telmisartan 47.6 µM -1.03029413277292 0.148064654377273 no 2865 0.151435976235679 962 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2998 9066762 71.4286 µM -1.03118524118653 0.147845742998047 no 2866 0.151226980172756 928 4945196
SGTC_354 2783-3500 4.88 µM -1.03185150803804 0.147682208273619 no 2867 0.151070842730786 929 6740761
SGTC_1198 1612-1005 86.7 µM -1.03254919751326 0.147511090788837 no 2868 0.150907456516682 953 6998509
SGTC_2021 4019055 173 µM -1.03298750626179 0.147403657789775 no 2869 0.150804872739782 939 44827708 YER133W GLC7
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.03345280461842 0.147289666807309 no 2870 0.150696023005168 930 688803
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.0354895268058 0.146791396486328 no 2871 0.150220177512511 928 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1808 st050063 61.5 µM -1.03580789077044 0.146713613210035 no 2872 0.150145887790271 938 4011993
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.03752829241956 0.146293760052898 no 2873 0.149744858619625 937 688664
SGTC_1776 st049249 45.9 µM -1.03912206340048 0.145905530916111 no 2874 0.149373985480586 954 1822314
SGTC_1098 clofazimine 15.1 µM -1.0429257287424 0.144981790281944 no 2875 0.148491346213877 952 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1926 methyl fluorone black 53.6 µM -1.04405195251305 0.144709037833739 no 2876 0.148230676925175 876 72721 Reacts with homocysteine.
SGTC_112 phenothiazine 287.218 µM -1.04437953567913 0.144629767627175 no 2877 0.14815491391568 938 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1429 4049-0205 9.46 µM -1.04450191034718 0.144600162301455 no 2878 0.148126617910267 929 22774478
SGTC_525 k781-2675 26.7 µM -1.04726039822009 0.143933902010859 no 2879 0.147489747792165 899 3651118 YDL195W SEC31
SGTC_1642 st009582 77.7 µM -1.04844112780697 0.143649353072898 no 2880 0.147217706549546 943 6739311
SGTC_3136 9095672 49.47 µM -1.04945744391216 0.143404731049109 no 2881 0.146983815858049 893 17217380
SGTC_734 2023-0417 80 µM -1.0501059318608 0.143248790432288 no 2882 0.146834705887273 965 3935732
SGTC_1316 1272-0050 65.9 µM -1.05103793432978 0.143024874284313 no 2883 0.146620583824106 941 7340392
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.05143990244613 0.142928373375621 no 2884 0.146528298732383 935 688662
SGTC_2976 9009005 19.48 µM -1.05649409515671 0.141718762852083 no 2885 0.145371268583082 893 2993148
SGTC_530 4358-1714 28 µM -1.05669824892995 0.141670049240551 no 2886 0.145324662212857 912 1564641
SGTC_475 α-linolenic acid 10 µM -1.05791662955173 0.141379564430936 no 2887 0.145046726493848 933 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.05973081154475 0.140947777932471 no 2888 0.144633540598969 938 165521
SGTC_1103 duloxetine 36.1 µM -1.06255488566815 0.140277412540318 no 2889 0.143991927622171 966 60835 A selective serotonin reuptake inhibitor.
SGTC_3108 9121785 49.47 µM -1.06354810891872 0.140042161436822 no 2890 0.143766730145288 892 17140271
SGTC_1321 1326-2144 215 µM -1.06426269296605 0.13987307366295 no 2891 0.143604856714255 953 3513030
SGTC_2763 lisinopril 49.32 µM -1.06449470214842 0.139818204562255 no 2892 0.143552326557909 936 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_578 3460-0051 92 µM -1.06603575487143 0.139454124065353 no 2893 0.143203739667898 972 2876744
SGTC_2519 cryptotanshinone 88.04 µM -1.06709937651269 0.139203215229732 no 2894 0.142963481680493 931 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2918 7977171 22.06 µM -1.06788239619025 0.139018696978082 no 2895 0.142786782118446 928 2236483
SGTC_328 k915-0120 63.5 µM -1.06842016904492 0.138892067523335 no 2896 0.142665511549648 940 6624543
SGTC_2986 9022445 71.43 µM -1.0686422623829 0.13883979409488 no 2897 0.142615448674296 911 6459286
SGTC_2314 7727897 200 µM -1.06982451984325 0.138561755275622 no 2898 0.142349151616421 913 900724
SGTC_1793 st048256 72.231 µM -1.07075646184165 0.138342852259995 no 2899 0.142139474001531 928 672022
SGTC_491 tetrandrine 80.3 µM -1.07103400278084 0.138277706497359 no 2900 0.142077070485597 946 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_587 k089-0003 57 µM -1.07323857930723 0.13776098037538 no 2901 0.141582042596945 912 9659696
SGTC_391 gliotoxin 8.33 µM -1.07413547251934 0.13755113697323 no 2902 0.141380984006159 957 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1421 4029-0249 71.4 µM -1.07433892226686 0.137503566826244 no 2903 0.141335403153871 943 2894095
SGTC_155 k072-0202 43.6 µM -1.0759219949803 0.137133800153457 no 2904 0.140981072075987 931 5857737
SGTC_1704 st028805 70.8 µM -1.07622725212149 0.137062577822289 no 2905 0.140912817281741 952 2876101
SGTC_2277 7947813 106.88 µM -1.07819874209067 0.136603200243293 no 2906 0.140472536599553 961 1246798
SGTC_833 3852-0053 558 µM -1.08018676155814 0.136141038383097 no 2907 0.140029511168084 977 3123681
SGTC_1899 st063254 59.6 µM -1.08255092523398 0.135592827444361 no 2908 0.139503899938899 942 3093813
SGTC_2608 thymoquinone 42.66 µM -1.08613163919299 0.134765401799076 no 2909 0.13871037811577 961 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3126 9127922 49.47 µM -1.08627925427689 0.134731365659818 no 2910 0.138677731263849 950 45595682
SGTC_1201 1889-3372 45.9 µM -1.08770937626157 0.134401922703218 no 2911 0.138361713576345 946 5392199
SGTC_504 lovastatin 124 µM -1.08802974814075 0.134328197719845 no 2912 0.138290987536558 964 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3351 9150312 21.596 µM -1.08988509360205 0.133901785947154 no 2913 0.137881881839192 945 4904905
SGTC_2583 asiatic acid 100 µM -1.09466585365523 0.132807319923857 no 2914 0.136831526698394 963 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.09765125768348 0.132127000272856 no 2915 0.136178400662261 931 5024745
SGTC_3153 9100258 49.47 µM -1.09858328101512 0.131915102044048 no 2916 0.135974936770322 956 25236848
SGTC_2638 epoxomicin 18 µM -1.09866181833672 0.131897257068834 no 2917 0.135957801316162 937 9915668 A protesome inhibitor.
SGTC_1708 st033234 31.827 µM -1.09879998279857 0.131865867865168 no 2918 0.1359276598632 947 674664
SGTC_316 k060-0003 58.6 µM -1.10203916461027 0.131131443395361 no 2919 0.135222322660931 957 6152314
SGTC_1627 st003713 25.6 µM -1.10326634774068 0.130853941746237 no 2920 0.134955758061368 962 16195070 YER133W GLC7
SGTC_1765 st044815 90.4 µM -1.1051930193644 0.130419084773575 no 2921 0.134537980496443 956 645695
SGTC_3265 9137266 49.47 µM -1.10919324941753 0.129519412698855 no 2922 0.133673412072379 922 17224265
SGTC_2886 9058944 51.95 µM -1.10938054067751 0.12947739556998 no 2923 0.133633026697781 926 4949929
SGTC_1668 st014914 51.6 µM -1.11121088322507 0.129067271605261 no 2924 0.133238793885826 960 2839556
SGTC_457 grayanotoxin iii 135 µM -1.11247526466705 0.128784488839022 no 2925 0.132966929795123 932 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2828 7998861 71.43 µM -1.11289140830083 0.128691511128667 no 2926 0.132877535234334 927 2988188
SGTC_1552 6-methylflavone 10.6 µM -1.11446673578701 0.128339962415737 no 2927 0.132539503624521 958 689013
SGTC_887 0885-0007 9.62 µM -1.11544749975852 0.128121433051858 no 2928 0.132329352141156 970 5719458
SGTC_2020 4017018 200 µM -1.11750970189559 0.127662785950279 no 2929 0.131888226839064 985 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2077 5212015 200 µM -1.11813866676041 0.127523127510923 no 2930 0.131753887173049 943 780900
SGTC_986 1493-0483 84 µM -1.11859622503089 0.127421595806737 no 2931 0.131656217330171 961 40079
SGTC_2470 5664817 21.68 µM -1.12016271345185 0.12707441942324 no 2932 0.13132221498538 971 2859561
SGTC_2890 9046729 58.44 µM -1.12053389534111 0.126992251993877 no 2933 0.131243158427671 949 903329
SGTC_1846 st056244 14.8 µM -1.12081391772946 0.126930288748178 no 2934 0.131183539325819 954 5393182
SGTC_23 0213-0011 39.996 µM -1.12146883003858 0.126785452182785 no 2935 0.131044176076513 969 627608
SGTC_3255 9139072 49.47 µM -1.12392627629773 0.126243003951369 no 2936 0.130522151526178 953 17646060
SGTC_2612 dictamnine 15.46 µM -1.12567223932771 0.125858590276447 no 2937 0.130152139178443 925 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_865 0488-0499 301 µM -1.12594889935098 0.125797752257759 no 2938 0.130093574828529 937 9634651
SGTC_2662 daunorubicin 22.37 µM -1.1285608830949 0.125224383448338 no 2939 0.129541559941252 921 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1504 k297-0033 30 µM -1.13005401285055 0.124897440443494 no 2940 0.129226732860074 900 4388117
SGTC_1461 k072-0203 53.8 µM -1.13356782245417 0.12413039396971 no 2941 0.128487938422175 942 5418714
SGTC_2730 imipramine 71.33 µM -1.13417099190552 0.123999057333799 no 2942 0.128361414711603 945 3696 A tricyclic antidepressant.
SGTC_56 0957-0365 83.25 µM -1.13738381040717 0.123301123391035 no 2943 0.127688936099234 954 6752360
SGTC_2692 st077426 47.7 µM -1.14451692906339 0.12176141833779 no 2944 0.12620466060365 982 25238571
SGTC_537 1334-0398 209 µM -1.1446089038823 0.12174165391187 no 2945 0.126185601132254 955 5846986
SGTC_1606 st000094 49.2 µM -1.14514468404545 0.121626565175622 no 2946 0.126074614033469 948 1242210
SGTC_3173 9105693 49.47 µM -1.14727294798271 0.121170156741601 no 2947 0.125634415395706 969 17096658
SGTC_2699 st077704 54.6 µM -1.14806601696849 0.121000390741802 no 2948 0.125470655866595 964 645852
SGTC_1845 st056753 3.01 µM -1.14876804970868 0.120850251846012 no 2949 0.12532581862018 965 5375839
SGTC_2280 7785178 200 µM -1.15166377235617 0.120232349524009 no 2950 0.124729632299576 953 2954328
SGTC_3073 9114972 49.47 µM -1.15257989578933 0.120037327295313 no 2951 0.124541429476784 949 41905075
SGTC_3024 9090631 49.47 µM -1.15269536644246 0.120012762001724 no 2952 0.124517721984582 950 25236383
SGTC_204 PMA1.184 62.41 µM -1.15356891616714 0.119827037322375 no 2953 0.124338474102608 972 2252213 YGL008C PMA1
SGTC_46 0329-0187a 2.197 µM -1.15443499430657 0.119643101317868 no 2954 0.124160937578814 955 46494817
SGTC_3094 9117742 49.47 µM -1.15750868004395 0.118991925639188 no 2955 0.12353229752501 972 17149698
SGTC_2189 6047310 154.431 µM -1.157692583851 0.118953044199805 no 2956 0.123494755735898 959 711535
SGTC_1468 k284-1086 134 µM -1.16111739407399 0.118230600396404 no 2957 0.122797080992407 966 15996457
SGTC_26 0302-0163 425.158 µM -1.16112029529509 0.118229989718757 no 2958 0.122796491153194 995 3100915
SGTC_2884 9058502 51.95 µM -1.16219773956849 0.118003352814 no 2959 0.122577576323313 965 6471554
SGTC_859 0439-0102 54.6 µM -1.16316948376728 0.117799213299314 no 2960 0.122380372567029 962 610143
SGTC_226 1,3-diallylurea 8.28947 mM -1.1641299636271 0.117597685842211 no 2961 0.122185673688137 963 74537 YKL182W FAS1
SGTC_1815 st051655 58.2 µM -1.16930966201939 0.116515090726883 no 2962 0.121139445872456 963 5984156
SGTC_1988 st071872 53.4 µM -1.17020213658728 0.116329273175256 no 2963 0.120959816611606 968 16414116
SGTC_2074 5212007 75.395 µM -1.17048574410309 0.116270268755438 no 2964 0.120902773901096 948 758611
SGTC_247 mechlorethamine 29.705 µM -1.17287497130451 0.11577403400096 no 2965 0.120422973891162 949 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2935 9038016 29.96 µM -1.17511609385777 0.115309928981923 no 2966 0.119974136371862 956 6463195
SGTC_1400 3771-8998 51.5 µM -1.17582422540422 0.115163560185014 no 2967 0.119832561840306 968 670767
SGTC_1969 st069479 40.1 µM -1.17685977391959 0.114949753126645 no 2968 0.119625739996299 963 3895485
SGTC_2522 biochanin a 4.94 µM -1.1775356476226 0.114810359561557 no 2969 0.11949088899461 965 5280373 A possible chelator.
SGTC_2270 7924575 90.91 µM -1.17782524853695 0.114750668498468 no 2970 0.11943314036225 965 1262135
SGTC_2769 toremifene 3.73 µM -1.17873489632502 0.114563320148906 no 2971 0.119251877728609 973 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1762 st045503 25.4615 µM -1.18208265876098 0.113875700170006 no 2972 0.11858645223136 995 4645554
SGTC_1827 berberine 7.24 µM -1.1863893608232 0.112995449219857 no 2973 0.117734285653396 936 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_645 0845-0943 5.41 µM -1.1879385845245 0.112679992666717 no 2974 0.117428803424824 964 1885106
SGTC_431 k089-0097 107 µM -1.18823201840114 0.112620313884175 no 2975 0.117371006218106 925 5499420
SGTC_1948 st076329 66.6 µM -1.18883371552733 0.112498010921579 no 2976 0.117252553901135 970 24208413
SGTC_130 0136-0219 337.655 µM -1.18962934868527 0.112336433593774 no 2977 0.117096052669159 979 234244
SGTC_2369 9071472 200 µM -1.18981329673781 0.112299101002114 no 2978 0.11705989111737 968 17296037
SGTC_851 0394-0702 453 µM -1.19028455999769 0.112203497721275 no 2979 0.116967283618404 981 762646
SGTC_396 dithiazanine 1.25 µM -1.19224348741564 0.11180672147978 no 2980 0.116582893137446 962 10578 An antihelmenthic.
SGTC_432 NS 1619 61.3 µM -1.19323858436714 0.111605551682092 no 2981 0.116387973751829 954 4552 A K+/calcium channel activator.
SGTC_1140 3229-1848 2.98 µM -1.19472922206489 0.111304687613647 no 2982 0.116096420690419 967 2849525
SGTC_1345 1488-0192 31.4 µM -1.19720149052833 0.110806976129249 no 2983 0.115614014525962 976 658348
SGTC_1354 1498-1681 81 µM -1.1972326449557 0.110800714380855 no 2984 0.115607944557078 984 5754243
SGTC_2640 pentamidine 10.38 µM -1.19874940727093 0.110496165931379 no 2985 0.115312700140089 931 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2495 cafestol 54.53 µM -1.19921543433746 0.110402713677205 no 2986 0.115222093657417 971 16667697 An anti-infammatory.
SGTC_110 0850-0284 111.64 µM -1.20003020829726 0.110239463499778 no 2987 0.115063804297956 930 3906265
SGTC_2071 5230951 39.92 µM -1.20105987066706 0.110033405475474 no 2988 0.114863988981632 981 1799272
SGTC_1185 1319-0113 81.3 µM -1.20246741522975 0.109752172223748 no 2989 0.114591241716649 984 4672763
SGTC_188 3229-0966 278.469 µM -1.20285612226406 0.109674597943568 no 2990 0.114516001209916 962 5722370
SGTC_2661 dactinomycin 12.96 µM -1.20294614474288 0.109656637768771 no 2991 0.114498580925431 975 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.20638489935601 0.108972160041345 no 2992 0.113834557895265 995 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1061 3448-9325 110 µM -1.20881856686401 0.108489602456856 no 2993 0.113366278428881 962 723482
SGTC_1250 0485-0349 40.2 µM -1.21016029330475 0.108224217779936 no 2994 0.113108695528101 978 6842794 YDL195W SEC31
SGTC_197 4544-0043 41.561 µM -1.21398457634057 0.107470364417496 no 2995 0.11237680697968 984 896523
SGTC_3048 9093155 49.47 µM -1.21415099007252 0.107437646619832 no 2996 0.112345035843036 949 25236002
SGTC_1455 4262-0120 131 µM -1.21663742013062 0.10694965639296 no 2997 0.11187109936415 964 1529587
SGTC_3144 9087057 49.47 µM -1.21700374793142 0.106877895744923 no 2998 0.111801394934713 968 17249618
SGTC_1043 0916-0009 19.3 µM -1.21831616184895 0.106621089671459 no 2999 0.111551925344652 982 3101130
SGTC_493 zm226600 134 µM -1.22031466125106 0.106230890076336 no 3000 0.111172807007964 979 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2977 9011197 71.43 µM -1.22038194275668 0.106217771582575 no 3001 0.111160059677534 950 2704722
SGTC_3270 9137563 49.47 µM -1.22391555104255 0.105530435205784 no 3002 0.110492043260916 944 17015724
SGTC_3264 9137442 49.47 µM -1.22450616289975 0.10541586736721 no 3003 0.110380671432528 959 17015726
SGTC_572 0960-0087 17.7 µM -1.22491357396891 0.105336889565255 no 3004 0.110303892751333 986 6796365
SGTC_2290 7904846 200 µM -1.22594287960357 0.105137546430348 no 3005 0.110110085516107 967 2962154
SGTC_2386 9075165 157.42 µM -1.22724014285883 0.104886697642896 no 3006 0.109866172841416 969 16452277
SGTC_512 prima-1 270 µM -1.23001527243503 0.10435153285984 no 3007 0.109345692911791 982 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2445 5742597 35.57 µM -1.23076090349558 0.10420808085415 no 3008 0.109206151003198 976 1774255
SGTC_3314 9135860 59.4275 µM -1.23341878827726 0.103697893262868 no 3009 0.108709779415147 957 25252478
SGTC_1755 st041960 45.185 µM -1.23784263392929 0.102852747650072 no 3010 0.107887208314834 985 2257073
SGTC_340 k038-0059 454 µM -1.23850346842204 0.102726930598478 no 3011 0.107764718406765 972 23733424
SGTC_1073 triclabendazole 3.09 µM -1.23874414369035 0.102681135950908 no 3012 0.107720132599211 979 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.23927174318183 0.102580798524346 no 3013 0.107622439728216 970 688788
SGTC_849 0386-0493 241 µM -1.24485516469972 0.10152332441055 no 3014 0.106592497075543 993 726119
SGTC_817 1391-0715 46 µM -1.24719620534563 0.101082312407199 no 3015 0.106162781980648 981 1353946
SGTC_3339 9145883 14.936 µM -1.24837880924098 0.100860061635463 no 3016 0.105946182779842 941 2030670
SGTC_1255 0566-0045 221 µM -1.25524541865995 0.0995766341121602 no 3017 0.104694841191411 976 2788469
SGTC_2511 berberine 10.47 µM -1.25659337800122 0.0993260966727099 no 3018 0.104450456919411 980 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.25922888173051 0.0988375827498862 no 3019 0.103973836197983 970 3256 An antibiotic and ribosome inhibitor.
SGTC_1511 0906-3109 28.5 µM -1.25948475521545 0.0987902481295691 no 3020 0.103927646592042 989 2882180
SGTC_2999 9069765 71.4286 µM -1.26175876551633 0.0983703024322603 no 3021 0.103517801941601 974 2097066
SGTC_3251 9135047 49.47 µM -1.26177759415375 0.0983668307783056 no 3022 0.103514413361531 987 17682963
SGTC_222 nsc-310342 10.666 µM -1.26192821250505 0.0983390627580226 no 3023 0.103487309552977 986 432556
SGTC_1871 st057448 67.3 µM -1.2621457283752 0.0982989716340158 no 3024 0.103448176610743 998 691747
SGTC_2050 5263056 171 µM -1.26230344587399 0.0982699096482711 no 3025 0.10341980861885 972 763468 YGL055W OLE1
SGTC_1711 st032263 62.8 µM -1.26237775334438 0.0982562194829559 no 3026 0.103406445199664 993 3958979
SGTC_2003 4023581 200 µM -1.26609826345404 0.09757254973883 no 3027 0.102738952131768 978 16641307
SGTC_1139 k015-0024 46.9 µM -1.26661153724165 0.0974785065940228 no 3028 0.102647112538077 984 2766652
SGTC_1653 st012112 65 µM -1.27026537128597 0.0968109636416162 no 3029 0.101995059394102 984 720429
SGTC_821 1114-0266 29.2 µM -1.27135166261769 0.09661315078491 no 3030 0.101801785353861 978 3123235
SGTC_2914 7968218 45.32 µM -1.27250246008012 0.0964039154544249 no 3031 0.101597325283223 960 2977111
SGTC_305 1682-2595 20.8 µM -1.27534944453877 0.0958877145626227 no 3032 0.101092792086135 977 226033
SGTC_2679 rapamycin 1 nM -1.27843894165411 0.0953298457202237 no 3033 0.100547350379034 933 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2709 st078560 56 µM -1.27950312569204 0.0951382409298055 no 3034 0.100359969811888 997 17250903
SGTC_884 0851-0618 334 µM -1.28854754066215 0.0935212436923507 no 3035 0.0987777155367757 979 9642473
SGTC_2870 9038528 12.99 µM -1.28996231574175 0.0932701512845052 no 3036 0.098531871280672 1004 6463316
SGTC_1493 4348-0038 111 µM -1.29179541112994 0.0929455571928313 no 3037 0.0982140024784792 988 800424
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.29308157009977 0.0927183105236587 no 3038 0.0979914243008823 1004 6710655
SGTC_2642 cholecalciferol 100 µM -1.29377070832218 0.0925967184382584 no 3039 0.0978723166450151 971 9821465 A vitamin D precursor, similar to steriods.
SGTC_614 0462-0418 107 µM -1.2960249386714 0.09219980427502 no 3040 0.0974834465629518 970 5188303
SGTC_522 1273-0010 11.6 µM -1.29905201885158 0.0916687933846162 no 3041 0.0969630388993665 962 5705015
SGTC_351 caspofungin 25 nM -1.30004591950215 0.0914949382527795 no 3042 0.0967926156600541 982 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_321 4534-3890 65.3 µM -1.30067624148694 0.091384807748722 no 3043 0.0966846489667538 989 699746
SGTC_1257 0669-0121 16 µM -1.3041927244733 0.090772207030467 no 3044 0.0960839399501835 976 4307855
SGTC_3313 9133968 57.047 µM -1.31161723196471 0.0894888143030891 no 3045 0.0948246579287754 975 1494643
SGTC_1188 1403-0014 4.57 µM -1.31201521520021 0.0894204023797242 no 3046 0.0947575004391925 972 9614867
SGTC_1828 st055811 49 µM -1.3132687927907 0.0892051710321432 no 3047 0.0945461951800913 990 5877589
SGTC_3105 9121040 49.47 µM -1.31397773816318 0.0890836203661738 no 3048 0.094426847977352 945 41448907
SGTC_1904 st060225 78 µM -1.31621037044715 0.0887016346961269 no 3049 0.0940517219669736 971 66595
SGTC_1654 st012436 41.8 µM -1.31630964845132 0.0886846773888256 no 3050 0.0940350668865815 1019 4323132
SGTC_1638 st008370 60.6 µM -1.31921316726884 0.0881898054007249 no 3051 0.0935489287441256 964 24207134
SGTC_1619 st003326 88.7 µM -1.3218057723118 0.0877496673415852 no 3052 0.0931164178553159 931 2849032
SGTC_2368 9071271 200 µM -1.32569549873302 0.0870923977888886 no 3053 0.0924702895016396 998 27209959
SGTC_2687 chenodiol 100 µM -1.3262610826251 0.0869971347950713 no 3054 0.0923766164169579 976 5702181 A cholesterol synthesis inhibitor.
SGTC_3345 9148410 3.559 µM -1.32678544659692 0.0869088841473118 no 3055 0.0922898330016415 963 4903596
SGTC_546 peri-Naphthalide 147 µM -1.32834860360341 0.086646201118561 no 3056 0.0920314850777331 984 223824 A penicillin ester.
SGTC_273 hydroxyurea 18.1 mM -1.33366934103212 0.0857565172744829 no 3057 0.0911561234219115 1015 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_29 0299-0004 12.984 µM -1.34155805784538 0.0844500508152531 no 3058 0.0898696665921873 998 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1117 retinoic acid 1.10837 µM -1.3443516472844 0.0839909970977576 no 3059 0.089417350865985 1020 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_209 4077-0173 175.592 µM -1.34755337748403 0.0834671832476031 no 3060 0.0889010372515852 996 15993494
SGTC_1691 st019933 84.6 µM -1.34811008474884 0.0833763551693446 no 3061 0.08881148915844 1018 6176082
SGTC_2840 9008771 71.43 µM -1.35529169200824 0.0822113117414854 no 3062 0.0876623204615958 985 2992978
SGTC_3043 9092303 49.47 µM -1.35553868349704 0.0821714625210204 no 3063 0.0876229962586212 996 25236084
SGTC_990 3985-0011 41.3 µM -1.35601293248322 0.0820949887225812 no 3064 0.0875475266587115 988 5399565 YGL099W LSG1
SGTC_1217 1183-1422 255 µM -1.35624895178578 0.0820569500251574 no 3065 0.0875099858154172 991 2849664
SGTC_2827 7993847 71.43 µM -1.35637511942477 0.0820366213192291 no 3066 0.0874899227258051 986 2985692
SGTC_1806 st050005 60.3 µM -1.35647292377443 0.0820208652468999 no 3067 0.0874743723088033 993 5194765
SGTC_683 panaxydol 45 µM -1.35793644213653 0.081785367803855 no 3068 0.0872419263136873 998 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1641 st009299 47.1 µM -1.35966435723936 0.0815079822980828 no 3069 0.0869680810743607 993 4046054
SGTC_2324 6149169 200 µM -1.36317432264635 0.0809467060510569 no 3070 0.0864137888346491 999 2888231
SGTC_1900 st060200 72.8 µM -1.36434222498282 0.0807605959179018 no 3071 0.0862299411259439 988 688945
SGTC_246 cycloheximide 667 µM -1.36806009602177 0.0801702888897005 no 3072 0.0856466329546154 1008 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3150 9097574 49.47 µM -1.36952774370852 0.079938162260799 no 3073 0.0854171842873044 995 17217476
SGTC_2362 9071156 126 µM -1.37047883781489 0.0797880065870576 no 3074 0.0852687384730736 1012 653133
SGTC_3139 9095020 49.47 µM -1.37856818294211 0.0785194992118723 no 3075 0.0840139660365925 969 25236292
SGTC_50 0929-0078 56.389 µM -1.38188715561915 0.0780034894364577 no 3076 0.0835031761871579 964 1377751
SGTC_1281 0884-0031 11.8 µM -1.38625985754044 0.0773275865390571 no 3077 0.0828337848509074 1010 1548255
SGTC_886 0866-0150 153 µM -1.38947650469241 0.0768332256604886 no 3078 0.0823439503107598 1010 271463
SGTC_2958 9077254 16.72 µM -1.38973768323279 0.0767931912999228 no 3079 0.0823042737038321 1009 16457351
SGTC_3321 9137793 26.8275 µM -1.39058111096045 0.0766640160532649 no 3080 0.0821762437646302 998 4904192
SGTC_1974 st069448 26.9 µM -1.39165508478391 0.0764997707553471 no 3081 0.0820134347812597 994 6323587 YNR016C ACC1
SGTC_2361 9034121 116 µM -1.39765636583394 0.0755869042323662 no 3082 0.0811081416233084 1023 6496917
SGTC_2625 euphol 100 µM -1.39935814477326 0.0753295598240815 no 3083 0.0808528057756189 997 6708538 A triterpene alcohol.
SGTC_1274 0865-0114 173 µM -1.40319397449155 0.0747519523717991 no 3084 0.0802795019548193 1016 870624
SGTC_2439 5492030 7.2 µM -1.4048222782135 0.0745077831383766 no 3085 0.0800370663191531 979 5722370
SGTC_2944 9067346 25.62 µM -1.40872953398269 0.0739243615858416 no 3086 0.0794575792076432 998 6473075
SGTC_2996 9066192 71.4286 µM -1.4102187254986 0.0737029203675473 no 3087 0.079237554127246 1000 6472854
SGTC_3118 9124250 49.47 µM -1.41384804272824 0.0731653687323328 no 3088 0.0787032620279276 986 1504786
SGTC_2329 6138490 200 µM -1.41569113777374 0.0728935321648434 no 3089 0.0784329771140451 1014 720019
SGTC_559 1550-0661 158 µM -1.4159978982347 0.072848363463548 no 3090 0.0783880599135131 1009 5830875
SGTC_2543 pimpinellin 60.67 µM -1.41644904359787 0.0727819738549495 no 3091 0.0783220366857359 1002 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2316 5844804 197.44 µM -1.41713971690016 0.0726804255767142 no 3092 0.0782210412574729 995 776813
SGTC_751 0833-0568 350 µM -1.42055450335942 0.0721799502226745 no 3093 0.0777231565008236 1022 6954252
SGTC_1232 0279-0259 161 µM -1.42201028147969 0.0719673943771394 no 3094 0.0775116331148008 1003 1560000
SGTC_784 4579-0127 173 µM -1.42250001978976 0.0718959964546792 no 3095 0.077440572886198 1012 1948547
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.42341911388038 0.0717621502931165 no 3096 0.077307347405111 1004 2724 A muscle relaxant with antifungal properties.
SGTC_1495 4469-0029 237 µM -1.42432232081879 0.0716308040312983 no 3097 0.077176594504555 1008 793680
SGTC_2928 9011484 9.79 µM -1.42913527645692 0.0709340018228531 no 3098 0.0764826780394095 970 2994751
SGTC_3252 9135871 49.47 µM -1.43298443278134 0.0703804915622394 no 3099 0.0759311430798044 1018 17682838
SGTC_2491 paeonol 100 µM -1.43418749381165 0.0702081738193902 no 3100 0.0757593824844442 1037 11092 Increases levels of cortical cytochrome oxidase.
SGTC_889 0919-1524 82.7 µM -1.43667662547146 0.0698526790615321 no 3101 0.0754049498354191 1008 3905452
SGTC_69 0096-0274 206.684 µM -1.43882866541588 0.0695464453344099 no 3102 0.0750995362668563 1025 6741392
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.44013786592107 0.0693606534205675 no 3103 0.0749141989617471 1013 6708760
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.44022999568126 0.0693475934684231 no 3104 0.0749011697406708 976 88881 An O-methylated flavonoid and antioxidant.
SGTC_939 1165-0479 45.3 µM -1.44121970556189 0.0692074155360397 no 3105 0.0747613115041363 996 1377347
SGTC_697 0508-1955 564 µM -1.44525934574679 0.0686375227225107 no 3106 0.0741925262561785 1013 6243113
SGTC_2211 7117706 200 µM -1.44769642861952 0.0682954654067406 no 3107 0.0738509845981041 1002 822771
SGTC_2457 5731572 11.68 µM -1.44795156779681 0.0682597314929783 no 3108 0.0738152980614038 1007 2865357
SGTC_2163 5671233 125 µM -1.4491327358927 0.0680944891598752 no 3109 0.0736502587845024 983 701023
SGTC_1090 efavirenz 20.7 µM -1.45123336199492 0.0678013802043137 no 3110 0.0733574449719286 998 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2782 7736369 71.43 µM -1.45857774450979 0.0667842437755185 no 3111 0.0723406813842453 1013 2950836 YOL077C BRX1
SGTC_2808 7946468 45.46 µM -1.46294794563143 0.0661846338791709 no 3112 0.0717408115824926 1018 2970879
SGTC_3180 9109287 49.47 µM -1.46555306791268 0.0658291890059875 no 3113 0.0713850424874182 1001 18891271
SGTC_2129 girgensonine 121.053 µM -1.47170530829548 0.0649956462411572 no 3114 0.0705502367653902 1020 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_77 0828-0286 12.516 µM -1.47670453941291 0.0643243726461088 no 3115 0.0698774274105486 1003 745345
SGTC_3127 9126946 49.47 µM -1.47776560968083 0.0641825925962092 no 3116 0.0697352631499347 1001 27243249
SGTC_441 propafenone 146 µM -1.47890022367075 0.0640312545228223 no 3117 0.069583491786696 1015 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1877 wortmannin 25 µM -1.47891097110731 0.0640298223265321 no 3118 0.0695820553753963 1026 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1253 0550-0034 176 µM -1.48031145496628 0.0638434077739374 no 3119 0.06939507382284 1011 5969915
SGTC_824 1304-0008 100 µM -1.49150692384838 0.0623683485002186 no 3120 0.0679142273760256 1025 768245
SGTC_2078 5212016 200 µM -1.49727674815981 0.0616185938796698 no 3121 0.0671606312308378 1022 1899708
SGTC_1074 carmofur 3.8 µM -1.49889041031466 0.0614101723970005 no 3122 0.0669510322894364 1033 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_298 1391-0729 10 µM -1.50049037216812 0.0612040645519776 no 3123 0.0667437127998029 1030 3237558
SGTC_745 0469-0705 296 µM -1.50185593550099 0.0610285799483555 no 3124 0.0665671593846788 1013 3486736
SGTC_3116 9124943 49.47 µM -1.50402412273681 0.0607507607476009 no 3125 0.0662875778209891 1003 41905195 YPL160W CDC60
SGTC_1004 4084-0029 199 µM -1.50422116512097 0.0607255619628105 no 3126 0.0662622149112975 1031 716894 YLR208W SEC13
SGTC_2566 crystal violet carbinol 226 nM -1.50500284189137 0.0606256776825996 no 3127 0.0661616730494636 1007 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_925 2064-1272 59.6 µM -1.50536654428229 0.0605792468676279 no 3128 0.0661149327414282 1015 6815817
SGTC_2191 5911152 200 µM -1.50581236892986 0.0605223701517808 no 3129 0.0660576735957693 1024 2875902
SGTC_1685 st024049 53.0905 µM -1.50961074253528 0.0600394800711966 no 3130 0.0655713893017185 1011 1941139
SGTC_2247 cerulenin 830 nM -1.51083704496429 0.0598842252275683 no 3131 0.065414986896293 1003 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_712 r015-0009 80.6 µM -1.5114087554742 0.0598119519250966 no 3132 0.0653421699988356 1035 6813872 YLR060W FRS1
SGTC_991 3996-0057 64.7 µM -1.51705805112444 0.0591014595440371 no 3133 0.0646260140571341 1015 715343
SGTC_173 1273-0061 2.693 µM -1.51801203611764 0.0589821361667017 no 3134 0.0645056822299853 984 2847414 YPL266W DIM1
SGTC_3061 glucosamine 200 µM -1.52468878496447 0.0581522985979908 no 3135 0.0636683701795872 1008 91431 and experimental redox chemotherapeutic
SGTC_2192 5915882 198.485 µM -1.52632388905162 0.0579504802149619 no 3136 0.0634646110486191 1029 2876149
SGTC_1971 st069429 63.5 µM -1.52920035190368 0.0575967793598045 no 3137 0.0631073916981202 1019 1246522 YGL099W LSG1
SGTC_1897 st060201 15 µM -1.53375233656004 0.0570405219602678 no 3138 0.0625452964383196 1030 611878
SGTC_2107 5363541 170.161 µM -1.53389408308143 0.0570232685254765 no 3139 0.0625278559389739 1018 244052
SGTC_1583 clindamycin 39.6 µM -1.53968164633707 0.0563223066672887 no 3140 0.0618189863842273 1037 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1746 st038117 42 µM -1.54728018945064 0.0554123412563152 no 3141 0.0608978483192684 1024 2898218
SGTC_937 3122-0005 46.7 µM -1.5474931128132 0.0553870107618169 no 3142 0.0608721919707614 1019 759535
SGTC_2080 5212524 12.4 µM -1.55088703496278 0.0549844849153592 no 3143 0.060464378983785 1012 260183
SGTC_2055 5235184 200 µM -1.55478713823512 0.0545247833241631 no 3144 0.0599983866586368 1017 2836034
SGTC_1952 st077036 64.1 µM -1.55515489276863 0.0544815937201918 no 3145 0.0599545920932233 1007 2937007
SGTC_938 3126-1755 342 µM -1.55537147852132 0.0544561702512378 no 3146 0.0599288113909898 1012 1777771
SGTC_2462 5162487 171.77 µM -1.55613194220584 0.0543669791086153 no 3147 0.0598383604000611 1045 2259986
SGTC_1305 1181-0477 144 µM -1.56079718792288 0.0538223412975279 no 3148 0.0592858055820474 1050 6252086
SGTC_2919 7978188 46.38 µM -1.56481042317225 0.053357286522511 no 3149 0.0588136835201865 1011 2980291
SGTC_3306 9127676 59.7925 µM -1.56547812902074 0.0532802225135379 no 3150 0.058735420835476 1015 41905287
SGTC_290 2043-6722 48.1 µM -1.56916110112432 0.0528567324230136 no 3151 0.058305202754958 1029 773758 YLR208W SEC13
SGTC_644 1498-1197 63.3 µM -1.56981784353796 0.0527814975485254 no 3152 0.0582287475687219 1039 6741615
SGTC_2898 9056270 58.44 µM -1.5706603347428 0.0526851081573134 no 3153 0.0581307836402179 996 19154699
SGTC_761 k216-0224 480 µM -1.57094545925044 0.0526525187245006 no 3154 0.0580976590287515 1053 1340404
SGTC_3034 9090421 49.47 µM -1.57327058577127 0.0523873559740305 no 3155 0.0578280885925139 1020 17173761
SGTC_1868 st057644 42.7 µM -1.5745722549443 0.0522393741984173 no 3156 0.0576776056180267 1040 688665
SGTC_1727 st034309 9.9045 µM -1.57785681018246 0.0518674412123704 no 3157 0.0572992545417622 1034 870305
SGTC_3040 9091894 49.47 µM -1.57882790908979 0.0517578809358247 no 3158 0.0571877675913167 1020 25236966
SGTC_1987 st072290 61.9 µM -1.58124812385643 0.0514856305006929 no 3159 0.0569106579272375 1036 54697379
SGTC_1311 1190-0148 100 µM -1.59016253259226 0.0504926570342573 no 3160 0.055899086779438 1027 1961333
SGTC_2186 6124449 200 µM -1.5913142235611 0.0503654909851008 no 3161 0.0557694386859656 1022 3834182 YLR033W RSC58
SGTC_2088 5278280 127.392 µM -1.59222402669612 0.0502652139707035 no 3162 0.0556671882266705 1035 791502
SGTC_2396 5342950 42.78 µM -1.59278786234748 0.0502031488357803 no 3163 0.0556038944691944 998 1886677
SGTC_444 curcumin 90.4 µM -1.59739392595167 0.0496984138713728 no 3164 0.0550889627844274 1011 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3114 9122766 49.47 µM -1.60007930530519 0.0494060220076954 no 3165 0.0547904956469913 1000 17176985
SGTC_1167 k781-0610 148 µM -1.60656804957049 0.0487051756113226 no 3166 0.054074578017134 1004 4525169
SGTC_487 nimodipine 119 µM -1.61637302303958 0.0476612459088877 no 3167 0.0530068436685199 1068 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2478 5763493 32.33 µM -1.6248509430146 0.0467731221858214 no 3168 0.0520971616116341 1018 1365576 YLR208W SEC13
SGTC_2995 9067767 71.4286 µM -1.63580137439885 0.0456456875801318 no 3169 0.0509405821490412 1024 11673567
SGTC_1194 1488-0194 225 µM -1.63641175617964 0.0455834923667503 no 3170 0.0508767201954964 1040 1391452
SGTC_384 k007-0144 5.16 µM -1.64422587623635 0.0447932722579377 no 3171 0.0500647769049486 1038 6824886
SGTC_1064 honokiol 6.76 µM -1.64483356724095 0.0447322833149515 no 3172 0.0500020689052227 1048 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1970 st070122 35.8 µM -1.64719494311519 0.0444959259870637 no 3173 0.0497589914531115 1039 102928
SGTC_2127 5253358 187.912 µM -1.64892470178808 0.0443234284344667 no 3174 0.0495815309131954 1041 20612
SGTC_264 promethazine 12.5 mM -1.65083104039199 0.0441339464125972 no 3175 0.0493865400011038 1032 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3119 9125183 49.47 µM -1.6511987712026 0.0440974707652324 no 3176 0.04934899697851 1032 22695334
SGTC_1882 5615643 20 µM -1.65379470928827 0.0438406675678748 no 3177 0.0490846156618953 998 2253075
SGTC_2650 prasterone 100 µM -1.65441616325316 0.0437793695377382 no 3178 0.0490214923001425 1040 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_599 1935-0052 86.5 µM -1.65565414702087 0.0436574652496756 no 3179 0.0488959390167996 1043 9557311
SGTC_1732 st034308 51.822 µM -1.66368691089308 0.0428731190648282 no 3180 0.0480875066744909 1020 830119
SGTC_2708 st078559 56 µM -1.66513161135536 0.0427332692864926 no 3181 0.0479432506291906 1017 17250902
SGTC_2014 4013930 200 µM -1.66533306460903 0.0427137975534554 no 3182 0.0479231626926493 1042 64556
SGTC_826 1683-5028 118 µM -1.67197952478045 0.0420753868980555 no 3183 0.0472641798338635 1034 722377
SGTC_988 1497-1057 103 µM -1.67217361519327 0.0420568606777393 no 3184 0.0472450458591134 1041 3533044
SGTC_1038 k292-0204 154 µM -1.68091331808989 0.0412294621222503 no 3185 0.0463898763491206 1038 4454212
SGTC_1936 st074407 74.3 µM -1.68682264270075 0.0406775335726315 no 3186 0.0458187301174037 1042 809813
SGTC_1672 st016598 6.51 µM -1.69236242083074 0.0401655806508114 no 3187 0.0452884464382971 1033 4665860 YNL267W PIK1
SGTC_2089 5281248 129.67 µM -1.69466693994901 0.0399541582398908 no 3188 0.0450693102935901 1034 2737878
SGTC_2866 9034245 58.44 µM -1.69665998816999 0.0397720411113784 no 3189 0.0448804806974593 1039 6462273
SGTC_2238 6671620 73.2395 µM -1.69689030758453 0.0397510389741617 no 3190 0.0448587004032841 1026 729941
SGTC_2746 daunorubicin 9.88 µM -1.70515743401007 0.0390031353703257 no 3191 0.0440825331633821 1046 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2187 6125751 200 µM -1.70709828234882 0.0388292232263533 no 3192 0.0439018931676133 1049 874498
SGTC_676 falcarinol 140 µM -1.71448415577589 0.0381731693775374 no 3193 0.0432199222547852 1033 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2747 doxorubicin 7.63 µM -1.71715800803959 0.0379379033420698 no 3194 0.0429751528505042 1015 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_276 colchicine 750 µM -1.72557161096551 0.0372053179415357 no 3195 0.0422122551673149 1049 2833 A microtubule depolymerizer.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.73120607702373 0.036721209459409 no 3196 0.0417075079394625 1048 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2310 7668677 200 µM -1.73767248260673 0.0361719834339808 no 3197 0.0411342700245188 1042 2197143
SGTC_3058 9093861 49.47 µM -1.74239843081336 0.0357748526241964 no 3198 0.040719375156961 1033 17217477
SGTC_1652 st011932 78 µM -1.74478124267362 0.0355759791483208 no 3199 0.0405114775439805 1031 1551076
SGTC_1183 1254-0324 198 µM -1.74499110167547 0.0355585074734476 no 3200 0.0404932089487312 1033 5799357
SGTC_1682 st012968 530 nM -1.75481316491953 0.0347486141450913 no 3201 0.0396456354975695 1025 24207270
SGTC_3294 9122953 26.2835 µM -1.76480356853634 0.0339404412030903 no 3202 0.0387983923553738 1050 16459826
SGTC_3337 9144342 33.5465 µM -1.76590214610983 0.0338525230527359 no 3203 0.0387061335504426 1040 17682949
SGTC_699 0375-0592 111 µM -1.77694005235453 0.0329795251173536 no 3204 0.0377890518033212 1044 762578
SGTC_3226 9131256 49.47 µM -1.77757647972663 0.0329297605126773 no 3205 0.0377367197876818 1035 17178073
SGTC_3021 9087658 49.47 µM -1.7821548399068 0.0325735828919434 no 3206 0.0373619924543164 1046 25237042
SGTC_113 0099-0221 2.5 µM -1.78682354620517 0.0322136550068097 no 3207 0.0369830062140791 1053 89219
SGTC_2311 7694451 200 µM -1.78832900792967 0.0320982957000775 no 3208 0.0368614712338128 1054 2163142
SGTC_933 2914-0560 114 µM -1.79329016036338 0.0317205480984968 no 3209 0.0364632699621854 1041 463887
SGTC_635 k038-0028 24.7 µM -1.80003442591585 0.0312129301130939 no 3210 0.0359276012656294 1062 4035102
SGTC_2024 5144227 134 µM -1.8009490422219 0.0311446102907571 no 3211 0.0358554560521057 1046 3475211
SGTC_40 0327-0103 19.753 µM -1.80303928251023 0.0309889382836845 no 3212 0.0356910228035288 1022 409036
SGTC_1805 st050013 60.3 µM -1.80358994373719 0.0309480347601713 no 3213 0.0356478068602191 1046 4037144
SGTC_1935 st074532 41.6 µM -1.81841025394257 0.029863845900331 no 3214 0.0345007261500203 1039 2829742
SGTC_2004 4023728 41.89 µM -1.82132885649745 0.0296540906011819 no 3215 0.0342784412501264 1038 360084 YDR527W RBA50
SGTC_2429 5902844 64.44 µM -1.82166843511557 0.0296297652224849 no 3216 0.034252655079909 1048 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2212 7123476 200 µM -1.82193106942456 0.0296109630320575 no 3217 0.0342327226727177 1064 1085715
SGTC_2487 5918373 44.05 µM -1.82532916880049 0.0293685821620167 no 3218 0.0339756854969382 1057 2876279
SGTC_1807 st050092 58.9 µM -1.82670870908437 0.0292706530978674 no 3219 0.0338717890537756 1058 5008496
SGTC_1972 st070201 17.4 µM -1.82734910308282 0.0292252858715755 no 3220 0.0338236483618984 1054 2829099
SGTC_1440 4100-1550 40 µM -1.84298881949146 0.0281353307565263 no 3221 0.0326653214542745 1066 742806
SGTC_3075 9116269 49.47 µM -1.84481107429377 0.0280105653984894 no 3222 0.0325325129587379 1045 17015205 YNL244C SUI1
SGTC_2983 9022671 12.99 µM -1.85729808326 0.0271679511284978 no 3223 0.0316343784859879 1052 6405161
SGTC_1809 st050081 57.6 µM -1.86184120272774 0.026866678814396 no 3224 0.0313127384194309 1054 5036894
SGTC_586 0957-0265 8.15 µM -1.86619385248576 0.0265806586667253 no 3225 0.0310071244318879 1024 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2536 dehydroabietamide 32.04 µM -1.87351922086729 0.0261050406096199 no 3226 0.0304983605421561 1054 3983547
SGTC_2032 5185112 25.99 µM -1.87704009131947 0.02587898405361 no 3227 0.0302562996299036 1049 5718189
SGTC_2008 4012253 172 µM -1.88403780194754 0.0254345588675112 no 3228 0.0297799311851407 1027 603940
SGTC_2382 9035899 200 µM -1.88601683877581 0.0253100358662724 no 3229 0.0296463427840455 1062 6462679
SGTC_720 r052-1644 49.9 µM -1.88726287110841 0.0252318965810564 no 3230 0.0295624888580042 1059 1422863 YOR257W CDC31
SGTC_2363 9053361 176 µM -1.89116388091191 0.0249885683505854 no 3231 0.029301235611934 1061 6469797 YMR079W SEC14
SGTC_1463 k081-0032 34.1 µM -1.90022599204476 0.0244308980029242 no 3232 0.0287017343471222 997 977755
SGTC_454 lyso-paf C-16 6.67 µM -1.90985283314781 0.0238499572816424 no 3233 0.0280760822496272 1058 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2556 citropten 84.59 µM -1.90998440944491 0.023842098333361 no 3234 0.0280676103582386 1042 2775 A potential DNA crosslinker.
SGTC_2932 9016711 44.54 µM -1.91879246586638 0.023320928369567 no 3235 0.0275053018647129 1066 7117328
SGTC_2461 5755302 26.15 µM -1.91949525123463 0.0232797610134738 no 3236 0.0274608433507437 1068 2788904
SGTC_2749 bexarotene 57.39 µM -1.91983400653613 0.0232599394585632 no 3237 0.0274394349509619 1045 82146 An retinoic acid receptor inhibitor.
SGTC_3095 9117207 49.47 µM -1.92302397895185 0.0230739807163385 no 3238 0.0272385192403936 1066 17015229
SGTC_3111 9122088 49.47 µM -1.93290248171313 0.0225060389818245 no 3239 0.0266241060548716 1070 16876704
SGTC_3323 9138564 53.9225 µM -1.94752808299375 0.0216868484099237 no 3240 0.0257357281519127 1054 43912313 YNL103W MET4
SGTC_2707 st078556 66.6 µM -1.94815253503136 0.0216524406122084 no 3241 0.0256983571481657 1048 17250899
SGTC_1309 pyrazolanthrone 13.4 µM -1.96404973183242 0.020791902553949 no 3242 0.0247621624400942 1058 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3291 9121177 71.43 µM -1.97170314083467 0.020388049279036 no 3243 0.0243217524485853 1065 17015612
SGTC_332 4112-0506 40.9 µM -1.97277890002558 0.0203318203098504 no 3244 0.0242603790679989 1065 2790355
SGTC_1783 st039459 87.517 µM -1.97555763208047 0.0201871864505097 no 3245 0.0241024505939135 1069 729761
SGTC_3096 9117468 49.47 µM -1.98371643501901 0.019767550141651 no 3246 0.023643730177947 1064 41316311
SGTC_2549 cedrol 20.94 µM -1.98803433939792 0.0195484770900332 no 3247 0.023403946136033 1058 6708665 A sedative which affects the nervous system.
SGTC_1343 1487-0095 224 µM -1.99004611242935 0.0194471140815954 no 3248 0.0232929280447469 1066 4560101 YGL055W OLE1
SGTC_2921 7974240 10.71 µM -1.99793138072467 0.0190541094707484 no 3249 0.0228620499786209 1057 2979074 YDR527W RBA50
SGTC_1674 st016616 23.6 µM -2.00072251040796 0.0189166265116632 no 3250 0.0227111510871912 1051 625830
SGTC_739 1486-1183 203 µM -2.00393273765136 0.0187595443003871 no 3251 0.0225386330476649 1066 4346692
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.0044212277457 0.0187357391746424 no 3252 0.0225124786328881 1041 279621
SGTC_339 3091-4833 71.4 µM -2.01592544508038 0.0181825019762561 no 3253 0.0219038862110293 1044 3240077
SGTC_21 0849-0113 22.993 µM -2.01707452164505 0.0181280156102629 no 3254 0.0218438685148181 1074 1560156
SGTC_2641 levomentholum 100 µM -2.01939287633683 0.0180185085201406 no 3255 0.0217232006863056 1065 16666
SGTC_166 k072-0058 166.424 µM -2.02202497599689 0.0178948658796954 no 3256 0.0215868858434536 1046 5846229
SGTC_1721 st082152 9.2685 µM -2.03021793213771 0.0175146240600589 no 3257 0.0211671959309589 1056 5296051
SGTC_1332 1480-0653 17.5 µM -2.03287923959472 0.0173926041866869 no 3258 0.0210323624736246 1066 5749438
SGTC_235 0330-0087 5 mM -2.03798880725514 0.0171603666697689 no 3259 0.0207755261196838 1072 46494818 YHR062C RPP1
SGTC_34 0469-0683 81.75 µM -2.04216328935324 0.0169726018976265 no 3260 0.0205676683175253 1060 3690923
SGTC_2676 harmalol 100 µM -2.04260451930554 0.0169528587617764 no 3261 0.0205458016890766 1056 5459187 A monoamine oxidase inhibitor
SGTC_622 1348-1566 26.3 µM -2.05878088586074 0.016242470139419 no 3262 0.0197576167666518 1075 7340407
SGTC_442 cape 100 µM -2.06451351772946 0.0159969150437258 no 3263 0.0194845267851751 1083 5281787
SGTC_727 3032-0951 202 µM -2.0650772682369 0.0159729397613957 no 3264 0.0194578449422584 1080 3652836
SGTC_2101 5377231 179.231 µM -2.06558288006713 0.0159514632193819 no 3265 0.019433941162748 1078 2844213
SGTC_3200 9114385 49.47 µM -2.06705790262538 0.0158889510512214 no 3266 0.0193643491121171 1052 17018030 YLR208W SEC13
SGTC_1903 st060211 78.3 µM -2.07505918013773 0.0155535010361182 no 3267 0.0189905251500244 1060 688960
SGTC_3205 9113483 49.47 µM -2.08158950038869 0.0152842424193256 no 3268 0.0186899906375848 1058 17018033
SGTC_858 0438-0351 2.77 µM -2.095744978377 0.0147142980412997 no 3269 0.0180524097911024 1082 2799119
SGTC_2261 9010538 184.68 µM -2.10238859380385 0.0144531710244398 no 3270 0.0177596247678056 1068 6457250
SGTC_1735 st034310 56.75 µM -2.10587854340805 0.014317604017309 no 3271 0.0176074519637452 1062 871153
SGTC_1961 st076550 68.7 µM -2.12019089298983 0.0137730346149303 no 3272 0.0169949750619655 1069 1579337
SGTC_1615 st002656 86.5 µM -2.12657408547612 0.0135359807801841 no 3273 0.0167277437910374 1076 1584458
SGTC_993 3909-8757 62.7 µM -2.13018953752398 0.0134032817123295 no 3274 0.0165779842427882 1064 4288324 YLR208W SEC13
SGTC_611 3453-1652 23.7 µM -2.13129753337519 0.0133628401288919 no 3275 0.0165323190773111 1080 1560575
SGTC_2017 5132927 60.65 µM -2.13254932995662 0.0133172766774824 no 3276 0.016480856854411 1070 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3318 9139014 38.6185 µM -2.14049865556615 0.0130310536434252 no 3277 0.0161572446684699 1069 16643984
SGTC_3225 9130819 49.47 µM -2.14927570315056 0.0127212198543713 no 3278 0.0158062756749836 1072 4547121
SGTC_946 3434-1334 87.4 µM -2.15220974037908 0.0126190784096798 no 3279 0.0156904194147339 1061 4047976
SGTC_1892 st058411 7.36 µM -2.15643025794514 0.0124733965157719 no 3280 0.0155250420559947 1078 3934738
SGTC_3093 9117344 49.47 µM -2.19515313655655 0.0112033826698678 no 3281 0.0140763073185256 1069 24824913
SGTC_717 1532-0246 73.2 µM -2.19939304535757 0.0110714015200567 no 3282 0.0139249933628797 1074 9561992
SGTC_2955 9076254 12.21 µM -2.20469559292383 0.0109082469764297 no 3283 0.0137377313000607 1069 16459619
SGTC_1220 1838-0075 193 µM -2.20889233577325 0.0107806042489526 no 3284 0.0135910652113529 1060 5529645
SGTC_3199 9111318 49.47 µM -2.21402927620608 0.0106261371650356 no 3285 0.0134133825370058 1069 8548020
SGTC_1026 k007-1105 30.6 µM -2.22167919836138 0.010399678800373 no 3286 0.0131524966585095 1072 7066794
SGTC_3348 9149464 3.537 µM -2.22425574058367 0.0103243590539043 no 3287 0.0130656213437515 1073 1951442
SGTC_1462 k081-0014 26.5 µM -2.25028209796259 0.00958981200605315 no 3288 0.0122155218049913 1001 3270634
SGTC_619 1652-1634 108 µM -2.25474439124801 0.00946856867002902 no 3289 0.0120746887769225 1082 5400454
SGTC_2199 6590217 200 µM -2.25556971291567 0.00944629164252248 no 3290 0.0120487958943055 1059 703109
SGTC_744 1594-0068 283 µM -2.25591545555478 0.00943697301138951 no 3291 0.0120379631994267 1073 668392
SGTC_511 blebbistatin 171 µM -2.25647475621763 0.00942191547764714 no 3292 0.012020457254573 1082 3476986 A myosin inhibitor.
SGTC_910 3454-3003 490 µM -2.25955692750724 0.00933931342726621 no 3293 0.0119243816998931 1069 820824
SGTC_2025 5147754 141 µM -2.2674936821447 0.00912951853884244 no 3294 0.0116800422072003 1048 315777 YLR208W SEC13
SGTC_2466 5983409 37.09 µM -2.28174704096606 0.0087630975888546 no 3295 0.0112521395351523 1084 2879657
SGTC_2829 7992743 58.44 µM -2.28575795826423 0.00866233884276829 no 3296 0.0111342112366987 1076 16462845
SGTC_3283 9109332 35.8195 µM -2.28680899774278 0.00863610414182861 no 3297 0.0111034870395928 1052 17027281
SGTC_926 2268-1401 59.4 µM -2.28715200574347 0.00862755751105511 no 3298 0.0110934761310534 1074 2931578
SGTC_1705 st027868 56.3335 µM -2.29112396943599 0.00852912829494604 no 3299 0.0109781223485949 1067 292948
SGTC_294 k038-0071 157 µM -2.29137740800103 0.00852288140909886 no 3300 0.0109707975323721 1084 24152826
SGTC_3334 9142812 21.919 µM -2.29172062602269 0.00851442799235908 no 3301 0.0109608847119064 1076 45283678
SGTC_580 1123-0028 41 µM -2.29857033125786 0.00834725242404101 no 3302 0.0107646749452982 1078 1677248 YPR107C YTH1
SGTC_105 0111-0055 734.78 µM -2.30676171104525 0.00815112124765341 no 3303 0.0105340539321911 1078 5179370
SGTC_353 1988-1175 58.3 µM -2.31756363523328 0.00789868124838055 no 3304 0.0102365242341371 1056 2788357
SGTC_1802 st050112 57.9 µM -2.3237673691838 0.007756830942587 no 3305 0.0100689827557803 1085 4662563
SGTC_1520 flindersine 88 µM -2.32615264409086 0.00770289048049914 no 3306 0.0100052044781329 1060 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_335 4077-0256 27.6 µM -2.33319515900576 0.0075455531425565 no 3307 0.00981895240466058 1063 3121989
SGTC_2716 st080858 38.6235 µM -2.33416476302297 0.00752411433024232 no 3308 0.00979354810800952 1069 5296050
SGTC_863 0466-0191 129 µM -2.33607679814288 0.00748199469203143 no 3309 0.00974361965320891 1083 765160 YPR165W RHO1
SGTC_2038 4100038 30.985 µM -2.34734858173887 0.00723788827752267 no 3310 0.00945377824760501 1051 3596803
SGTC_669 0108-0021 26.2 µM -2.37793545386974 0.00661052020800966 no 3311 0.00870493656016194 1070 17201
SGTC_2960 9079389 5.97 µM -2.3822924439448 0.00652518200301482 no 3312 0.0086026139466038 1071 16457355
SGTC_2757 clomiphene 4.22 µM -2.38766450567745 0.0064213044163727 no 3313 0.00847790619777267 1080 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2045 5106652 78.05 µM -2.39417918029169 0.00629729768353217 no 3314 0.00832880448309333 1075 673349
SGTC_2433 5607874 27.82 µM -2.41589194460794 0.00589916678025764 no 3315 0.00784835936835514 1067 2252428
SGTC_1315 1237-0019 3.69 µM -2.42416114944605 0.00575351247622875 no 3316 0.00767189752063487 1075 825140
SGTC_2670 beta-carotene 100 µM -2.43243781068559 0.005610931715911 no 3317 0.00749878337213381 1086 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3309 9129340 25.759 µM -2.4513580094717 0.00529671982362085 no 3318 0.00711591619392318 1079 17158987
SGTC_3284 9108171 64.8615 µM -2.5299300691621 0.00415289547572859 no 3319 0.00570426312085024 1074 8687505
SGTC_2204 7233102 200 µM -2.54747913515108 0.00392982686980799 no 3320 0.005425217072929 1085 2172480
SGTC_2463 5473429 200 µM -2.55186907217751 0.00387573149849615 no 3321 0.0053573387300476 1083 5399405
SGTC_708 3448-5400 146 µM -2.61503542779918 0.00316791885554352 no 3322 0.00446091003920166 1084 3462195
SGTC_2378 9074213 121.43 µM -2.6211898429133 0.00310559410586974 no 3323 0.00438117263177293 1087 657714
SGTC_2970 9090938 41.86 µM -2.66883213028934 0.00265927933833366 no 3324 0.00380577410790362 1080 17217104
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.67891161596561 0.00257262694154285 no 3325 0.00369309436988974 1080 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_702 1488-0190 94 µM -2.74177204548442 0.0020874321244008 no 3326 0.00305543670320313 1090 949357
SGTC_42 0133-0086 60.653 µM -2.755562522967 0.00199278443117462 no 3327 0.00292956526113648 1075 162923 Model of phenazepam hydroxylation.
SGTC_228 caffeine 993.056 µM -2.75925150983213 0.00196813529805894 no 3328 0.00289669640389639 1092 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_687 k029-0044 34.9 µM -2.76993775867565 0.00189828654065631 no 3329 0.00280335027802225 1093 5829338
SGTC_2754 granisetron 64.02 µM -2.83174221569838 0.00153666847520902 no 3330 0.00231475776289887 1081 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2534 helenine 20.12 µM -2.85121294545834 0.00143649820570309 no 3331 0.00217763955805927 1080 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_665 3914-0008 307 µM -2.85680492886497 0.00140885189400481 no 3332 0.00213964372161254 1091 1069549
SGTC_3331 9141060 1.957 µM -2.85827199235573 0.00140167975355005 no 3333 0.00212977552483958 1087 4906567 YPR165W RHO1
SGTC_3310 9130229 44.1445 µM -2.8788698936503 0.00130444082844796 no 3334 0.00199551473610111 1091 7761258
SGTC_839 0122-0028 230 µM -2.89618672575931 0.00122750671159017 no 3335 0.00188863785377163 1089 759448
SGTC_673 1082-0474 110 µM -2.90405699476024 0.00119393290743893 no 3336 0.00184180547995445 1079 3098046
SGTC_694 1315-0438 43.2 µM -2.95440130417318 0.000998314893412898 yes 3337 0.00156638169920891 1090 6793154
SGTC_2335 9018011 154.17 µM -2.9576519718698 0.000986756299422077 yes 3338 0.00154995950326928 1089 6458208
SGTC_2555 cholic acid 100 µM -2.98677489150161 0.000888550911219662 yes 3339 0.00140968619703646 1087 6708657 Influences liver metabolism.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -3.00351428556028 0.000836253398743905 yes 3340 0.00133440509612946 1094 91467 include heat shock
SGTC_221 trifluoperazine 10.304 µM -3.0394564989432 0.000733394980388179 yes 3341 0.00118502713698235 1088 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_142 0335-0849 62.6745 µM -3.07955029080932 0.000632490955287762 yes 3342 0.0010365668317878 1089 3889043 YPR107C YTH1
SGTC_672 1441-0018 53.7 µM -3.11199704176351 0.000560390241441903 yes 3343 0.000929131805971805 1092 251141
SGTC_911 3456-4043 236 µM -3.11779593267187 0.000548334220873823 yes 3344 0.000911044587035793 1091 914281
SGTC_998 3996-0085 177 µM -3.20513415958273 0.000393473936440756 yes 3345 0.000674997703104142 1091 715391
SGTC_927 2425-1185 123 µM -3.31846321523942 0.000252724883131415 yes 3346 0.00045257121761779 1093 730375
SGTC_136 0097-0015 404.482 µM -3.34887054452136 0.000223897837743277 yes 3347 0.000405708493885054 1090 4861337
SGTC_1675 st018485 24.5 µM -3.59852534937193 7.97953602672763e-05 yes 3348 0.000160013330788196 1092 3323024
SGTC_1723 st034307 2.5525 µM -3.71811965081133 4.75394584880018e-05 yes 3349 0.00010035560282186 1089 867466
SGTC_679 0422-0091 41.4 µM -3.7717543825196 3.74983965192326e-05 yes 3350 8.10518913582782e-05 1094 627384 YHR062C RPP1
SGTC_1717 st033143 58.0435 µM -3.91322599884115 1.97588632675458e-05 yes 3351 4.55356133665104e-05 1094 674616
SGTC_44 0929-0055 61.211 µM -4.32782865238028 2.66778464083151e-06 yes 3352 7.52932727424634e-06 1078 1379590
SGTC_24 0417-1663 219 µM -4.74586140277818 2.93191756873717e-07 yes 3353 1.03810422961041e-06 1095 4329390
SGTC_138 0850-0259 40.9225 µM -5.27865010795371 1.33213051784561e-08 yes 3354 6.5069516463703e-08 1093 6813004
SGTC_116 0155-0182 31.788 µM -8.44531589494448 2.14174306537061e-19 yes 3355 1.51612181781686e-17 1088 771486