SGTCid condition conc unit BUD26|YDR241W.score BUD26|YDR241W.strain.pval BUD26|YDR241W.strain.significant BUD26|YDR241W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2688 kanamycin b 96.69 µM 7.22985270608661 3.9744023033886e-12 yes 1 2.41759083464877e-13 97 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1919 st067113 52.3 µM 5.90066210949878 1.1821647572699e-08 yes 2 1.81022844947509e-09 10 1268243 SGTC_3272 9137413 49.47 µM 5.8843398222694 1.29173168303872e-08 yes 3 1.99822982438162e-09 2 17614870 SGTC_3212 9128307 49.47 µM 5.58286521205431 6.36938816057201e-08 yes 4 1.18294051414301e-08 18 27243542 SGTC_276 colchicine 750 µM 5.52627689455773 8.51816621614519e-08 yes 5 1.63548876067122e-08 5 2833 A microtubule depolymerizer. SGTC_756 0508-1999 28.3 µM 5.00175049972912 1.10484642854748e-06 yes 6 2.84060427134485e-07 8 6753853 SGTC_422 cantharidin 155 µM 4.73216090797743 3.76038488797996e-06 yes 7 1.110711018297e-06 37 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_212 3807-4682 38.772 µM 4.67702119025692 4.79388298583479e-06 yes 8 1.45536094769523e-06 43 3125501 YBL034C STU1 SGTC_2817 7995342 71.43 µM 4.63491762977543 5.76033787437361e-06 yes 9 1.78539818769355e-06 14 18879975 SGTC_608 k048-0125 159 µM 4.58472656051004 7.1559429965933e-06 yes 10 2.2729047038287e-06 17 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1844 rapamycin 4 nM 4.53569604552276 8.8267741570582e-06 yes 11 2.8706908858566e-06 126 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_118 0083-0097 135.343 µM 4.43452161224133 1.3521802159157e-05 yes 12 4.61384815006586e-06 89 5207356 SGTC_1394 3474-0001 65.7 µM 4.17732156994984 3.84438286338082e-05 yes 13 1.47480941497718e-05 34 5017666 YIL048W NEO1 SGTC_3270 9137563 49.47 µM 4.08876569939322 5.43758351211181e-05 yes 14 2.16837306952788e-05 6 17015724 SGTC_1728 st035614 33.7865 µM 4.08435882315412 5.53125530620131e-05 yes 15 2.20993440008418e-05 40 15945546 SGTC_176 1486-1328 72.834 µM 4.06708888440073 5.91321723100656e-05 yes 16 2.38020446728336e-05 49 22310231 SGTC_824 1304-0008 100 µM 4.01293578919098 7.27856725177181e-05 yes 17 2.99841149407475e-05 39 768245 SGTC_367 0335-0881 7.1 µM 3.97381447742262 8.44406925128961e-05 yes 18 3.53653319520435e-05 80 23828853 SGTC_2238 6671620 73.2395 µM 3.93878746424264 9.63448594660461e-05 yes 19 4.09472167832087e-05 32 729941 SGTC_642 0335-0876 158 µM 3.92126823395425 0.000102874303485593 yes 20 4.40420721412398e-05 42 6812350 SGTC_2094 5332512 191.667 µM 3.88042723441466 0.000119745077973022 yes 21 5.21365692157465e-05 24 755774 SGTC_2710 st078562 53.7235 µM 3.82664896758569 0.000145936812263088 yes 22 6.49497753594558e-05 19 17250908 SGTC_2044 5102272 200 µM 3.82162153828485 0.000148642006132655 yes 23 6.62885231029349e-05 12 592666 SGTC_593 1203-0218 61.7 µM 3.803599124358 0.000158730487335294 yes 24 7.13044456372181e-05 12 3666956 SGTC_853 0419-0306 21 µM 3.79260150423847 0.00016519789561081 yes 25 7.45386414266275e-05 17 762713 SGTC_2423 st077119 87.2 µM 3.77004558045469 0.000179241384374958 yes 26 8.1608867762153e-05 16 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_33 0986-0033 35.816 µM 3.7573446137934 0.000187632701420985 yes 27 8.58629665867549e-05 25 2848082 SGTC_1511 0906-3109 28.5 µM 3.67658923272242 0.000250187360074394 yes 28 0.000118186598226637 64 2882180 SGTC_2890 9046729 58.44 µM 3.67283824290133 0.000253519544188333 yes 29 0.000119935666631162 28 903329 SGTC_2679 rapamycin 1 nM 3.65561516828595 0.000269357539341907 yes 30 0.00012828299627974 167 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_873 0591-4978 488 µM 3.64522238304453 0.000279355574950831 yes 31 0.000133580339600985 24 3305145 SGTC_528 3492-0019 172 µM 3.61446618733266 0.000311005266429077 yes 32 0.000150483544938541 249 2869262 SGTC_717 1532-0246 73.2 µM 3.54606483258983 0.0003937225830079 yes 33 0.000195514995396012 47 9561992 SGTC_1730 st033808 45.1 µM 3.53642045077864 0.00040690619141872 yes 34 0.000202794314276255 52 1045166 SGTC_2748 diazoxide 86.69 µM 3.50767538024683 0.000448669109156516 yes 35 0.000226020140986558 16 3019 A potassium channel activatior. SGTC_2789 5281112 71.43 µM 3.48345396638773 0.000486907872719306 yes 36 0.000247494119235208 61 765948 SGTC_1427 4048-4900 550 nM 3.46826174654958 0.00051240946282354 yes 37 0.000261918398353309 40 24132586 SGTC_1501 4491-0275 38.4 µM 3.4584149251054 0.00052959267031748 yes 38 0.00027168192485076 23 5104718 SGTC_317 4495-0002 170 µM 3.45205672994028 0.000540969663956341 yes 39 0.000278165372524733 22 15991618 SGTC_357 1325-0123 420 µM 3.44070564415061 0.000561844420693112 yes 40 0.000290099676052574 14 1098503 SGTC_770 0389-1121 67.2 µM 3.42110907932942 0.000599643824002726 yes 41 0.000311831564813234 48 6753108 SGTC_1126 isoteolin 1.0172 µM 3.32411074620022 0.000823769387822431 yes 42 0.000443504820779801 58 133323 SGTC_1359 1582-0056 520 nM 3.31781353332415 0.000840700011502753 yes 43 0.000453625144830296 39 3661189 SGTC_1829 berberine 14.4 µM 3.31352664534904 0.000852408199604208 yes 44 0.000460636642904165 34 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3164 9100705 49.47 µM 3.28955861773397 0.000920677901844996 yes 45 0.000501723265519955 15 17174235 SGTC_2087 5276107 200 µM 3.26490472375428 0.000996112317474287 yes 46 0.000547504512390798 37 144405 SGTC_1802 st050112 57.9 µM 3.25876243149605 0.00101576875742136 no 47 0.000559496644286429 30 4662563 SGTC_2727 riluzole 51.77 µM 3.23441782578501 0.0010972271235681 no 48 0.000609454955409977 29 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2022 5136654 200 µM 3.22706230107739 0.00112299196516353 no 49 0.000625341127234425 46 1713771 SGTC_2743 auranofin 4.32 µM 3.21713596614911 0.00115864086663946 no 50 0.00064738611289872 62 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_975 1335-0046 28.5 µM 3.20573477289463 0.00120086358732368 no 51 0.000673590494727442 78 16486740 SGTC_182 3448-4371 550.524 µM 3.19419578337509 0.00124502648534069 no 52 0.000701104930635785 52 3491403 SGTC_800 3448-7362 155 µM 3.16661608029925 0.00135666585024869 no 53 0.000771118898455148 240 15991913 SGTC_309 k408-0051 1.48 µM 3.14051366957649 0.00147067544717311 no 54 0.000843259183531966 109 3640463 SGTC_1912 st060209 90.8 µM 3.11636527078256 0.00158386718066219 no 55 0.000915476622481685 74 688787 SGTC_2467 5474540 200 µM 3.11208892429323 0.00160472043346817 no 56 0.000928842662821561 55 5413519 SGTC_46 0329-0187a 2.197 µM 3.08070922360706 0.00176555909690646 no 57 0.00103254105799182 127 46494817 SGTC_565 1418-0001 44.5 µM 3.06508352638672 0.00185100153822364 no 58 0.00108804607345391 62 2862145 SGTC_1875 nocodazole 6 µM 3.04976042481676 0.00193842320566986 no 59 0.00114511988901384 77 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2035 5154463 94.595 µM 3.04122488493337 0.00198873105883352 no 60 0.00117808888880243 54 2769623 SGTC_1444 4112-3581 28 µM 3.02636899759848 0.00207912549445223 no 61 0.00123755023659768 44 2877249 SGTC_420 mitomycin C 81.9 mM 3.02617261191271 0.00208034502520263 no 62 0.00123835434957411 57 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2555 cholic acid 100 µM 3.02043826162171 0.00211624202075775 no 63 0.00126204580547791 48 6708657 Influences liver metabolism. SGTC_1408 3909-7976 48.8 µM 3.01273478758073 0.00216534999860033 no 64 0.00129452536795349 67 24152374 SGTC_361 000s-0510 1.45 µM 3.00712755379867 0.00220174212643936 no 65 0.00131864538284113 84 660 SGTC_879 0831-1030 162 µM 2.96157882628455 0.00251853095654934 no 66 0.00153033068555463 119 1549252 SGTC_2191 5911152 200 µM 2.92675079815695 0.00278795515555876 no 67 0.00171261606805519 61 2875902 SGTC_2928 9011484 9.79 µM 2.88938559396382 0.00310568393331913 no 68 0.00192997717364183 82 2994751 SGTC_2397 5161689 200 µM 2.85298605464496 0.00344617892519002 no 69 0.00216552610680028 99 2259942 SGTC_297 0986-0032 24 µM 2.84434913785023 0.00353174149951933 no 70 0.00222511272307579 44 2847425 SGTC_832 4083-0019 164 µM 2.81814388661509 0.00380314244656121 no 71 0.00241510793887355 214 1990758 SGTC_2785 7756463 72.73 µM 2.79887633526241 0.00401446516323686 no 72 0.00256403864898088 89 2201551 SGTC_474 dl-dihydrosphingosine 5 µM 2.79128117118719 0.00410061575174453 no 73 0.00262499220763393 94 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3210 9128157 49.47 µM 2.78600847255665 0.00416139222933808 no 74 0.00266807384805062 127 17590849 SGTC_2028 5153890 36.43 µM 2.76786742272947 0.00437670068167042 no 75 0.00282122018359419 82 2830968 YPR165W RHO1 SGTC_1417 3966-0327 90.4 µM 2.7261404797893 0.0049101510319727 no 76 0.00320398595280905 84 651118 SGTC_2870 9038528 12.99 µM 2.70115598125363 0.00525661274875264 no 77 0.00345494618019855 87 6463316 SGTC_1467 k284-1082 293 µM 2.69859485282398 0.00529332882831951 no 78 0.0034816445574146 82 3334705 SGTC_841 0251-0215 91.2 µM 2.69674365873811 0.00532000919742097 no 79 0.00350105747730274 147 3888614 SGTC_2515 chrysin 20.77 µM 2.69637831729987 0.00532528879544041 no 80 0.00350490016976977 63 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2194 5927483 104.545 µM 2.68309596165778 0.0055204254921861 no 81 0.0036472028224761 90 760979 SGTC_731 3966-0296 387 µM 2.64919551858846 0.00604755863141879 no 82 0.00403418194261088 84 660956 SGTC_1623 st003709 20.3 µM 2.64575807064007 0.00610342364767436 no 83 0.00407540436478587 179 16192618 SGTC_1740 st038286 13.222 µM 2.64317926286024 0.00614563385766753 no 84 0.00410657692828887 112 716786 SGTC_3084 9116877 49.47 µM 2.64245318073759 0.00615756501399765 no 85 0.00411539220258358 43 27241325 SGTC_1429 4049-0205 9.46 µM 2.64022379812586 0.00619432709137105 no 86 0.00414256477688867 73 22774478 SGTC_837 0091-0265 12.5 µM 2.63270933777835 0.00631967501434637 no 87 0.00423534021931077 103 759367 SGTC_679 0422-0091 41.4 µM 2.63098196065115 0.0063488046760269 no 88 0.00425692775007509 122 627384 YHR062C RPP1 SGTC_748 act1.228 77.9 µM 2.62147668663106 0.00651123316340664 no 89 0.00437748750482692 175 4421505 YNR035C ARC35 SGTC_2704 st078022 71.1 µM 2.62124728186288 0.00651519830532709 no 90 0.0043804344825464 77 54697681 SGTC_986 1493-0483 84 µM 2.62028394052913 0.00653187248324358 no 91 0.00439282911232755 79 40079 SGTC_2246 7293507 91.5585 µM 2.59909253896771 0.00690833932950219 no 92 0.00467352858974132 119 887656 SGTC_11 0438-0307 1.3 µM 2.59615599385002 0.00696199088535526 no 93 0.00471366270216293 85 4011476 SGTC_2469 5655019 90.81 µM 2.59387468612094 0.00700392460547415 no 94 0.00474505349178518 103 2788239 SGTC_652 0437-0092 114 µM 2.59222228591367 0.00703443716843158 no 95 0.00476790680427433 80 3091274 SGTC_2970 9090938 41.86 µM 2.59179698272335 0.00704230960646949 no 96 0.00477380476611953 161 17217104 SGTC_253 dyclonine 31.25 µM 2.58603235185896 0.00714978341926067 no 97 0.00485439086671786 120 3180 An oral anasthetic. SGTC_2027 5150920 200 µM 2.57571756771079 0.00734570351315723 no 98 0.0050016159040301 74 786715 SGTC_1821 st053465 65.6 µM 2.56052072779459 0.00764297487636146 no 99 0.00522577142770495 69 675086 SGTC_3157 9099274 49.47 µM 2.53926335250748 0.00807655146343871 no 100 0.00555430844978701 81 17217662 SGTC_493 zm226600 134 µM 2.53894736464465 0.00808315634963061 no 101 0.00555932748277147 110 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1154 4088-0362 150 µM 2.5354937699793 0.00815565462838041 no 102 0.00561444628879399 134 6618304 SGTC_2667 digitoxin 100 µM 2.52576979491711 0.00836285926503477 no 103 0.00577225504868184 51 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_175 3793-3120 23.7 µM 2.52460072727458 0.00838807912750253 no 104 0.00579149027486215 105 5322297 SGTC_1351 1496-0003 46.5 µM 2.48753892205584 0.00922297862242539 no 105 0.00643151887383119 109 3891978 SGTC_320 4092-0846 5.34 µM 2.48441674623491 0.00929652596697897 no 106 0.00648819233765879 135 1359356 SGTC_926 2268-1401 59.4 µM 2.46234615047168 0.00983122126566276 no 107 0.00690156889105768 123 2931578 SGTC_229 benomyl 22.8748 µM 2.4614631777557 0.00985316037224836 no 108 0.00691858003481614 116 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_766 1391-0721 126 µM 2.45202586716206 0.010090331550586 no 109 0.00710272248667664 119 1020919 YIL115C NUP159 SGTC_2944 9067346 25.62 µM 2.4519633688755 0.0100919186699437 no 110 0.0071039562409871 146 6473075 SGTC_449 xestospongin c 11.1929 µM 2.44642104465901 0.010233532806382 no 111 0.00721411976644113 180 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1771 st048882 4.1505 µM 2.42858944654176 0.0107009785717983 no 112 0.00757884283824126 111 4580403 SGTC_951 1171-0579 82.7 µM 2.42797163682763 0.0107175020815312 no 113 0.00759176532371796 232 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2502 avocadyne acetate 18.59 µM 2.42049224378994 0.0109193100527349 no 114 0.00774975497094825 163 3952079 SGTC_2958 9077254 16.72 µM 2.41988967229617 0.0109357115584752 no 115 0.00776260833696372 139 16457351 SGTC_2115 tiliquinol 12.7705 µM 2.41364734546308 0.0111068878568779 no 116 0.00789687026720654 97 71208 A bioactive hydroxyquinoline. SGTC_3058 9093861 49.47 µM 2.41082884926256 0.0111849367969336 no 117 0.00795815774239374 133 17217477 SGTC_759 3486-0358 89.3 µM 2.39835836189515 0.0115360150614231 no 118 0.00823437214077155 135 875103 SGTC_1313 1220-0047 237 µM 2.39095820728269 0.0117488424184475 no 119 0.00840223281110627 162 3528706 SGTC_2943 9068529 45.32 µM 2.38719706108112 0.0118583126336359 no 120 0.00848869414451006 148 3270634 SGTC_672 1441-0018 53.7 µM 2.38659425948528 0.0118759395316727 no 121 0.00850262371850538 116 251141 SGTC_2077 5212015 200 µM 2.38470552991984 0.0119313163186858 no 122 0.0085463985552387 176 780900 SGTC_2255 7941087 197.44 µM 2.37979178827066 0.0120764357150218 no 123 0.00866121133624374 155 935561 SGTC_1712 st032288 53.4 µM 2.37664490737944 0.0121701754696146 no 124 0.0087354488189909 356 2883011 SGTC_954 1189-0853 2.85 µM 2.36856266503366 0.0124138255288457 no 125 0.00892867749443639 163 2828194 SGTC_148 3253-0744 288.01 µM 2.36151846623519 0.0126296167752526 no 126 0.00910013273024368 137 6893655 SGTC_584 0986-0246 15.4 µM 2.35713883587088 0.0127654124187957 no 127 0.00920818000738082 130 53315 YDR232W HEM1 SGTC_41 0478-0632 82.643 µM 2.34922578427598 0.013013970744911 no 128 0.0094062476474142 177 3750424 SGTC_1106 tegaserod maleate 11.7 µM 2.34163217594794 0.0132564179731452 no 129 0.00959981313524314 159 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1399 3562-5772 25 µM 2.32890804134005 0.0136714214817677 no 130 0.00993196892369939 115 23847490 SGTC_1820 st053765 18.6 µM 2.32865136644959 0.0136799071132297 no 131 0.00993877124751063 138 3690829 SGTC_2432 5630864 12.22 µM 2.32435015229196 0.0138227821501909 no 132 0.0100533674424367 169 5714970 SGTC_290 2043-6722 48.1 µM 2.32350787482869 0.0138509105741519 no 133 0.010075942554326 142 773758 YLR208W SEC13 SGTC_283 0987-0079 11.7 µM 2.32318250633316 0.0138617896841322 no 134 0.0100846750693776 170 411556 SGTC_2845 9003024 42.97 µM 2.31488192906793 0.014141832601321 no 135 0.0103096972916355 202 2990173 SGTC_3218 9131285 49.47 µM 2.31447192737277 0.0141557905869443 no 136 0.0103209247020913 210 17156417 SGTC_684 1140-0066 328 µM 2.30999922786431 0.0143088306010112 no 137 0.0104440984358961 186 6813534 SGTC_1338 1486-1223 76 µM 2.30300144008065 0.0145511286002955 no 138 0.0106393810344766 150 3444526 SGTC_3151 9099821 49.47 µM 2.30021936070898 0.0146484343826404 no 139 0.0107178977499126 147 17174189 SGTC_2799 7812892 81.82 µM 2.29624029209112 0.0147885786882161 no 140 0.0108310729633664 164 20205235 SGTC_2884 9058502 51.95 µM 2.28319826442638 0.0152560367428276 no 141 0.0112093461569195 166 6471554 SGTC_563 tetrahydrosecaminediol 614 µM 2.27729358272508 0.0154718142876651 no 142 0.0113843499512256 156 334274 A psychoactive constituent of the cannabis plant. SGTC_3194 9111903 49.47 µM 2.26590721637081 0.0158953154435838 no 143 0.011728532347033 152 17087251 SGTC_1426 4048-4480 71.7 µM 2.2631305842731 0.0160000834003112 no 144 0.0118138203555517 138 14224343 SGTC_285 1486-1325 46 µM 2.26304096549038 0.0160034747359505 no 145 0.0118165820592808 146 22310230 SGTC_2985 9022375 71.43 µM 2.25581603186258 0.0162789139054367 no 146 0.0120410774445255 176 4939335 SGTC_1945 st075991 56.6 µM 2.25372505696821 0.0163593827349678 no 147 0.012106735007769 144 1084980 SGTC_685 1278-0033 54.9 µM 2.2527896067216 0.016395492626545 no 148 0.0121362089121397 171 3590572 SGTC_2190 6049624 200 µM 2.24724283607804 0.0166110120007015 no 149 0.0123122559725265 94 2265554 SGTC_1413 3910-0535 34.4 µM 2.24042186698605 0.0168793599298685 no 150 0.0125317739901329 142 2876951 SGTC_168 3970-0862 530.542 µM 2.23090347086649 0.0172600193418857 no 151 0.0128437618929231 386 3135186 SGTC_1559 coumarin 343 70.1 µM 2.22145666325586 0.0176450429519073 no 152 0.0131600234157681 138 108770 A hepatotoxic, DNA x-linker. SGTC_3306 9127676 59.7925 µM 2.21958136137479 0.0177223403893383 no 153 0.0132235993260485 168 41905287 SGTC_214 4373-3496 70 µM 2.2128707330564 0.0180013146856796 no 154 0.0134532794843261 273 3779166 SGTC_1252 0493-0875 34.8 µM 2.19298894118287 0.0188499179478616 no 155 0.0141540879361056 188 3960963 SGTC_356 1634-0012 32.5 µM 2.1922354840323 0.0188827356278614 no 156 0.0141812537556497 182 735457 SGTC_1826 st055655 41.6 µM 2.18893580380399 0.0190270300644333 no 157 0.0143007531497039 194 676168 SGTC_1398 3558-0053 112 µM 2.1864198774376 0.0191376801712874 no 158 0.0143924503318183 106 4532369 SGTC_1521 st012942 49.4 µM 2.17987630499814 0.0194280302663336 no 159 0.0146333158909017 199 24207259 SGTC_1087 pterostilbene 9.05 µM 2.17970286140173 0.0194357769056685 no 160 0.0146397471646404 184 5281727 Similar to reservatol, lowers cholesterol. SGTC_830 4076-0286 57.8 µM 2.16997214422581 0.0198746102326945 no 161 0.0150044781227086 325 6866659 SGTC_2193 5925765 200 µM 2.16784331524107 0.0199717285504834 no 162 0.0150853049661615 126 877370 SGTC_1846 st056244 14.8 µM 2.16667722960048 0.0200250964677988 no 163 0.0151297370112105 211 5393182 SGTC_2982 9019404 25.97 µM 2.16289887123742 0.0201988513098848 no 164 0.0152744793093043 185 22333232 SGTC_159 3970-0959 50 µM 2.15868654949558 0.0203940681413708 no 165 0.0154372464944933 371 6615653 SGTC_3153 9100258 49.47 µM 2.1447724527223 0.0210503082328342 no 166 0.015985522372188 198 25236848 SGTC_308 4092-1169 104 µM 2.13607743223075 0.0214694016956078 no 167 0.0163365514507703 226 2268590 YDL196W YDL196W SGTC_687 k029-0044 34.9 µM 2.13350286767228 0.0215948390175497 no 168 0.0164417483318562 171 5829338 SGTC_2120 5538279 151.968 µM 2.12703136134907 0.0219128797860501 no 169 0.0167087387653353 179 2058197 SGTC_851 0394-0702 453 µM 2.11730557460012 0.0223982847228801 no 170 0.0171169610482014 173 762646 SGTC_1721 st082152 9.2685 µM 2.11095534826603 0.0227200877202574 no 171 0.0173880750021648 181 5296051 SGTC_3013 9080133 71.4286 µM 2.10858755592926 0.0228410707826625 no 172 0.0174900989715329 213 17050193 SGTC_1860 st056228 74.6 µM 2.10341989166428 0.0231070001203693 no 173 0.0177145405684569 181 688679 SGTC_3126 9127922 49.47 µM 2.09858373596125 0.0233582267744589 no 174 0.0179268056527199 229 45595682 SGTC_1523 st012844 44.7 µM 2.0974878119362 0.0234154757465375 no 175 0.0179752074877836 206 4274103 SGTC_1880 MG-132 525 µM 2.09191387057695 0.0237084781554833 no 176 0.0182231105354175 163 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1505 k297-0037 20.6 µM 2.09124275677934 0.0237439632916979 no 177 0.0182531541554179 198 4089396 SGTC_2994 9053520 71.4286 µM 2.08533036737336 0.0240585147147315 no 178 0.0185196613678757 190 4647384 SGTC_1910 st062352 60.4 µM 2.06195630371422 0.0253365494656166 no 179 0.0196059481530619 244 2245730 SGTC_1158 4092-0494 91.8 µM 2.06040955982181 0.0254230910721277 no 180 0.0196797018806311 185 1148199 SGTC_749 1000-0129 128 µM 2.05999749831033 0.0254461879767441 no 181 0.0196993899893876 211 708470 SGTC_3281 9140613 49.47 µM 2.05956799494769 0.0254702812368253 no 182 0.019719929257687 174 16013766 SGTC_386 1509-0011 3.07 µM 2.05920853614534 0.0254904599862458 no 183 0.0197371328986211 338 3107280 SGTC_149 3970-0822 46.1 µM 2.05888191924976 0.0255088067142307 no 184 0.0197527757771486 364 3114250 YBL034C STU1 SGTC_1474 0330-0125 5.35 µM 2.05721459157617 0.0256026362569142 no 185 0.0198327942852391 179 X1474 SGTC_246 cycloheximide 667 µM 2.04467985474141 0.0263173256680545 no 186 0.0204432154893612 153 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1107 amlodipine 47 µM 2.04332522879889 0.0263955509572337 no 187 0.0205101268757253 238 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_432 NS 1619 61.3 µM 2.03926662832554 0.0266310862307099 no 188 0.0207117121700173 212 4552 A K+/calcium channel activator. SGTC_3261 9137475 49.47 µM 2.03678979748391 0.0267756864440403 no 189 0.0208355555756975 63 17027690 SGTC_2933 9026794 32.47 µM 2.03490553210113 0.0268861306172307 no 190 0.0209301896288749 234 17586027 SGTC_3305 9127027 53.8275 µM 2.03197450357648 0.027058685448169 no 191 0.0210781185814871 212 41905295 SGTC_1499 4480-0877 67.3 µM 2.02956508379797 0.0272012234915526 no 192 0.021200383540707 136 2861909 SGTC_2232 chlorophetanol 41.5365 µM 2.02809735598779 0.0272883589252732 no 193 0.0212751563617315 343 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_797 k781-0471 270 µM 2.01508704934953 0.0280709747180455 no 194 0.0219477644745706 214 23738129 SGTC_2856 9022925 19.48 µM 2.01469632683473 0.0280947641629678 no 195 0.0219682386602217 231 4944862 SGTC_1782 st039423 80.636 µM 2.01255212838996 0.0282256143809246 no 196 0.0220808837258296 223 2068169 SGTC_1961 st076550 68.7 µM 2.01112933046375 0.0283127206484332 no 197 0.0221558989248108 184 1579337 SGTC_1997 st073024 93.8 µM 1.98965381718224 0.0296548873606406 no 198 0.0233145416887535 194 686268 SGTC_3044 9093193 49.47 µM 1.98558935414019 0.0299147572378555 no 199 0.0235394697524513 261 25236277 SGTC_187 1488-2104 32.728 µM 1.98348180616211 0.0300502495769256 no 200 0.0236568186738792 234 2852859 SGTC_968 1309-0633 340 µM 1.96646061514339 0.0311632800929791 no 201 0.0246227137542859 214 3761976 SGTC_2289 7946404 165.07 µM 1.94791438404875 0.0324146355212925 no 202 0.025712604187896 331 1246120 YPR165W RHO1 SGTC_3003 9075612 71.4286 µM 1.9446410504698 0.0326397421470945 no 203 0.0259090975053475 226 6501993 SGTC_2411 st077133 39.94 µM 1.94274993866308 0.0327703801166097 no 204 0.0260231896017659 289 1403142 YNL221C POP1 SGTC_1790 st045711 43.5 µM 1.94218984820758 0.0328091537956893 no 205 0.0260570608038721 208 585119 SGTC_599 1935-0052 86.5 µM 1.94041407395863 0.0329323363779656 no 206 0.0261646937704792 239 9557311 SGTC_2148 5546263 113.568 µM 1.93495333527595 0.0333135293689114 no 207 0.0264980111638387 231 792097 SGTC_791 1348-1292 225 µM 1.93168125411181 0.0335436765707993 no 208 0.0266994299613615 317 5437054 SGTC_787 4152-0075 138 µM 1.9295873762574 0.0336916384810808 no 209 0.0268289920990852 238 9566539 SGTC_321 4534-3890 65.3 µM 1.92823047599032 0.0337878090475076 no 210 0.0269132325326724 192 699746 SGTC_415 dibenzyl ketone 100 µM 1.92667824866962 0.033898100298206 no 211 0.0270098701172138 219 7593 SGTC_704 1310-0270 142 µM 1.91748635829984 0.034557300915652 no 212 0.0275880862056961 282 5718033 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.91634628247305 0.034639791126524 no 213 0.0276605167125377 252 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_338 4055-0136 114 µM 1.91631131957189 0.0346423234216318 no 214 0.0276627404536484 255 2900563 SGTC_3017 9080681 49.47 µM 1.9126451811662 0.034908699758435 no 215 0.0278967457280716 224 16451914 SGTC_1001 4048-4355 44.4 µM 1.90941963172087 0.0351444517809198 no 216 0.0281039901279592 237 21824233 SGTC_864 0469-0573 172 µM 1.89895457464034 0.0359183410909417 no 217 0.0287852244122098 233 689425 SGTC_1324 1418-0026 34.4 µM 1.87877822070476 0.0374497760251462 no 218 0.0301373910295551 268 1372513 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.86949799809484 0.0381718599767941 no 219 0.030776780948059 282 140250 A respiratory chain inhibitor. SGTC_2000 st075254 36.4 µM 1.86749058750216 0.0383295386964498 no 220 0.0309165550178937 199 17234175 SGTC_2373 9071805 200 µM 1.85911154796715 0.0389934418463774 no 221 0.0315056643774708 227 10149009 SGTC_2653 dihydrofissinolide 100 µM 1.85441460967555 0.0393696747081694 no 222 0.031839933123849 192 6857746 SGTC_2295 7971645 200 µM 1.85295333352122 0.0394873260275218 no 223 0.031944523857731 281 2978226 YKL099C UTP11 SGTC_2569 tetrandrine 100 µM 1.85058716380383 0.0396784391407067 no 224 0.0321144838857794 230 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1400 3771-8998 51.5 µM 1.84958667029819 0.0397594739062476 no 225 0.0321865727389807 202 670767 SGTC_2859 9028643 45.46 µM 1.84434625344944 0.0401861210862503 no 226 0.0325663473681694 217 17151580 SGTC_1025 k007-0731 70 µM 1.84400602497483 0.0402139487742887 no 227 0.0325911310646803 259 6256118 SGTC_2277 7947813 106.88 µM 1.84139777290114 0.0404278011126014 no 228 0.0327816444724446 290 1246798 SGTC_728 3030-5151 22.5 µM 1.84062535318709 0.0404913092456468 no 229 0.0328382398782212 241 3125388 SGTC_782 0083-0095 30.5 µM 1.83603674898057 0.0408702546018166 no 230 0.0331761108863816 324 3591729 An indicator and reagent. SGTC_2623 humulene 100 µM 1.83579840208564 0.040890016585033 no 231 0.0331937389464502 215 6187145 An anti-inflammatory. SGTC_1352 1496-0991 99 µM 1.82791206581291 0.0415482773537808 no 232 0.0337813749576026 283 3000039 SGTC_645 0845-0943 5.41 µM 1.82653188321604 0.0416643571356334 no 233 0.0338850916080863 253 1885106 SGTC_87 0100-0052 35.5 µM 1.82610675726249 0.041700165081277 no 234 0.0339170912861095 510 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2888 9058547 12.99 µM 1.82510503334188 0.0417846378820712 no 235 0.0339925903937756 204 16476514 SGTC_2489 cantharidin 73.42 µM 1.82462156713205 0.0418254568959263 no 236 0.0340290782640121 333 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_247 mechlorethamine 29.705 µM 1.82098326940745 0.0421336749082151 no 237 0.0343047000576217 224 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1932 st074806 40.9 µM 1.82082176290902 0.0421473994104201 no 238 0.0343169775029078 312 17251235 SGTC_2959 9079155 11 µM 1.81860218376496 0.0423363816129843 no 239 0.0344860722160012 238 16189457 SGTC_489 paxilline 115 µM 1.81275384932127 0.0428376120309184 no 240 0.0349348974594553 254 105008 A toxic potassium channel blocker. SGTC_2348 9022543 33.42 µM 1.80851459418221 0.0432039263098716 no 241 0.0352632237454896 297 3162678 YDL140C RPO21 SGTC_2449 5812982 45.77 µM 1.80804613681398 0.0432445605023113 no 242 0.035299660122669 225 776185 SGTC_104 0074-0074 590.992 µM 1.80623246428817 0.0434021703717782 no 243 0.0354410179756941 156 3943124 SGTC_269 exalamide 29 µM 1.8008889391298 0.0438692252241176 no 244 0.035860193355886 237 3316 A derivative of salicylamide. SGTC_1722 st034304 3.6505 µM 1.79542170357521 0.0443512804872664 no 245 0.0362932685420616 312 4036148 YLR033W RSC58 SGTC_708 3448-5400 146 µM 1.79431275423189 0.0444495772368224 no 246 0.0363816317518756 324 3462195 SGTC_2972 9093619 59.92 µM 1.79133299653479 0.0447145712657346 no 247 0.0366199370510352 291 25236256 SGTC_194 1486-1323 56.904 µM 1.79085793600767 0.0447569364116617 no 248 0.036658047642105 272 5178754 SGTC_1970 st070122 35.8 µM 1.79049524559215 0.044789302322423 no 249 0.0366871654450754 312 102928 SGTC_2907 7721985 69.9 µM 1.78748688804825 0.0450584903599663 no 250 0.0369294147351786 297 3267881 SGTC_503 tyrphostin 8 294 µM 1.78535634559034 0.0452499178655133 no 251 0.0371017673882027 308 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_409 arachidonic acid 100 µM 1.78209090615171 0.0455445842755235 no 252 0.0373672042683102 282 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1807 st050092 58.9 µM 1.78135405672332 0.0456112889228366 no 253 0.0374273143504452 275 5008496 SGTC_1835 st008666 49.2 µM 1.77832519682548 0.0458863074350695 no 254 0.0376752301828971 228 690455 SGTC_913 3487-1245 167 µM 1.77553673620103 0.0461406744051229 no 255 0.0379046526895724 316 4016153 SGTC_1495 4469-0029 237 µM 1.7713239345078 0.046527118294782 no 256 0.0382534247777913 444 793680 SGTC_969 1313-0238 134 µM 1.76188478227058 0.0474024115165236 no 257 0.0390443831270068 351 5212874 SGTC_150 3970-0969 77.2 µM 1.76099458863311 0.0474856355773897 no 258 0.0391196594509825 386 6615640 SGTC_575 k072-0246 11.9 µM 1.76057580769668 0.0475248278078457 no 259 0.0391551131355128 299 6796779 SGTC_2406 ethylparaben 405.7 µM 1.7547599536998 0.0480717962913941 no 260 0.0396501880716453 277 8434 A possible steroid mimic. SGTC_2713 st079149 53.4 µM 1.75029684071585 0.048494949471449 no 261 0.0400335528939501 317 3103253 SGTC_2118 5526350 200 µM 1.74807197127037 0.0487070017591071 no 262 0.0402257828542436 314 743594 SGTC_188 3229-0966 278.469 µM 1.74680213191025 0.0488283619693219 no 263 0.0403358333335693 361 5722370 SGTC_744 1594-0068 283 µM 1.74512253107189 0.0489892546853607 no 264 0.0404817711949349 362 668392 SGTC_1794 st048918 76.9 µM 1.74166658411209 0.0493216397942748 no 265 0.0407834014579066 226 672303 SGTC_407 eburnamonine 100 µM 1.73909494326959 0.0495701408539641 no 266 0.0410090319924997 267 3195 SGTC_2593 nobiletin 86.24 µM 1.73866848183597 0.0496114468097912 no 267 0.0410465465333784 266 72344 An anti-infammatory. SGTC_3109 9122853 49.47 µM 1.7358756491052 0.0498826327302114 no 268 0.0412929121510765 284 1234709 SGTC_2081 5214970 32.255 µM 1.73536815295596 0.049932037651558 no 269 0.0413378086097358 289 2063512 SGTC_1201 1889-3372 45.9 µM 1.73253762798697 0.0502083064169742 no 270 0.0415889417651966 262 5392199 SGTC_727 3032-0951 202 µM 1.71213939676083 0.052235437489605 no 271 0.0434354912882139 308 3652836 SGTC_3052 9092717 49.47 µM 1.70543756427913 0.0529154586338204 no 272 0.0440564237364472 317 25237534 SGTC_711 k292-0785 179 µM 1.70372818045212 0.0530900254194877 no 273 0.0442159404276677 319 4146315 SGTC_59 0330-0160 1.33 µM 1.70052970557466 0.0534178884288686 no 274 0.0445156668642478 502 4293482 SGTC_196 k015-0023 18.111 µM 1.69764407190629 0.0537150582085247 no 275 0.044787479717766 345 5211998 SGTC_377 3970-0964 33.1 µM 1.69384342230559 0.0541084548500673 no 276 0.0451475201894112 430 16481235 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.69148282176873 0.0543539409962429 no 277 0.0453723129711752 407 688664 SGTC_192 3455-0609 60.9 µM 1.68521903911841 0.0550096030313379 no 278 0.0459731595339227 313 3769639 SGTC_554 4483-2211 187 µM 1.68179385447788 0.0553707686358013 no 279 0.0463044104172958 335 747107 SGTC_1445 4239-0156 97.7 µM 1.67792531642689 0.0557809321262162 no 280 0.0466808397896145 372 4008346 SGTC_2803 7707263 71.43 µM 1.67594294474311 0.0559920410272165 no 281 0.0468746844175625 307 2199229 SGTC_2524 avocatin b 10.57 µM 1.67338779134037 0.0562650762731292 no 282 0.0471254898455627 290 6710748 SGTC_2208 7283366 200 µM 1.67227882902305 0.0563839024781509 no 283 0.0472346761813056 315 898663 SGTC_2124 5246320 200 µM 1.67064113952109 0.0565597438618501 no 284 0.0473962907209263 331 579342 SGTC_2476 5806916 10.51 µM 1.66650916043381 0.0570053217950132 no 285 0.0478060225988578 305 2870194 SGTC_332 4112-0506 40.9 µM 1.66637660882633 0.0570196613092712 no 286 0.0478192133720461 329 2790355 SGTC_13 0199-0087 65 µM 1.66564435762225 0.057098927877102 no 287 0.047892135320612 333 4589825 SGTC_3006 9075424 71.4286 µM 1.66468794915342 0.0572025901920202 no 288 0.0479875142287788 333 7465181 SGTC_2181 6316240 54.2555 µM 1.65205787581448 0.058585463122715 no 289 0.049261376551279 314 12779990 SGTC_282 k297-0036 65.7 µM 1.65194065659728 0.0585984193571557 no 290 0.0492733244630152 291 5061378 SGTC_1667 st014849 34.6 µM 1.65178850103506 0.0586152404590324 no 291 0.0492888368149913 328 5348460 SGTC_3107 9121808 49.47 µM 1.65054474001786 0.0587528829034102 no 292 0.0494157852677388 240 662681 SGTC_765 1319-0117 244 µM 1.64633836747191 0.0592202670464452 no 293 0.0498470572248325 319 3487746 YGL099W LSG1 SGTC_2387 9077560 195.08 µM 1.64514324372565 0.0593535917719087 no 294 0.0499701373024683 349 5303272 SGTC_184 1494-0393 24.714 µM 1.64379130333334 0.0595046940794385 no 295 0.0501096591855371 387 3090647 SGTC_199 4063-0024 41.6 µM 1.6434849792212 0.0595389728654252 no 296 0.0501413153226409 312 306215 SGTC_740 k014-0057 261 µM 1.64011356654247 0.0599172695647497 no 297 0.0504907780713888 387 4012779 SGTC_1152 3909-8331 15.9 µM 1.63919065075113 0.0600211548703403 no 298 0.0505867801654825 320 16001939 SGTC_1246 0422-0085 105 µM 1.63768577012983 0.060190849772973 no 299 0.0507436302688521 387 264295 SGTC_1169 aniline yellow 25.8 µM 1.63680930496878 0.0602898555790319 no 300 0.0508351604463617 306 6051 A DNA damaging agent. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.63273409327272 0.0607518679690745 no 301 0.0512624668565974 292 61125 An anti-inflammatory. SGTC_3082 9117008 49.47 µM 1.63124730001257 0.0609211154982826 no 302 0.0514190742051894 340 41448529 SGTC_3183 9108214 49.47 µM 1.62558166021067 0.0615694383589123 no 303 0.0520193396245175 200 4974831 SGTC_1255 0566-0045 221 µM 1.62416525286322 0.0617323576815414 no 304 0.0521702722633233 378 2788469 SGTC_115 0527-0192 112.043 µM 1.62343757069227 0.0618161885858934 no 305 0.0522479493535611 471 4233931 SGTC_2235 salicylic acid 500 µM 1.61937417820884 0.062285936663158 no 306 0.0526833895970684 285 338 A COX inhibitor and kinase inhibitor. SGTC_1579 chlormadinone acetate 49.4 µM 1.61888819728186 0.0623423043430684 no 307 0.0527356604002919 357 45114258 A steroidal progestin. SGTC_1069 diphenylcyclopropenone 8.49 µM 1.61708472801577 0.0625518319107725 no 308 0.0529299964835883 434 65057 A dermal irritant. YDR527W RBA50 SGTC_2296 7971656 126.45 µM 1.61454330513141 0.0628480265170784 no 309 0.0532048157932907 394 666570 SGTC_2874 9043904 71.43 µM 1.60339864873591 0.0641598205305121 no 310 0.0544233345930791 287 4463428 SGTC_2378 9074213 121.43 µM 1.60010439837802 0.064551621918236 no 311 0.0547877127114387 396 657714 SGTC_140 0062-0056 502.533 µM 1.59984412702952 0.06458265631848 no 312 0.0548165834156365 416 3758964 SGTC_469 w7 172 µM 1.59884749656058 0.0647016003420659 no 313 0.0549272462529084 259 45115570 A P450 inhibitor. SGTC_631 k072-0230 41.5 µM 1.59673409584642 0.0649543894290182 no 314 0.0551624959953212 399 5773147 SGTC_1729 st035615 45.989 µM 1.5916930851708 0.0655604522248175 no 315 0.055726841400596 376 17385451 SGTC_465 cgp-37157 41 µM 1.5915157457432 0.0655818526871608 no 316 0.0557467773524469 245 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_210 3551-0445 56.827 µM 1.58802531302303 0.0660041645540889 no 317 0.0561403076540293 392 2865180 YOR207C RET1 SGTC_949 1165-0505 146 µM 1.58638681148477 0.066203134240378 no 318 0.0563257951553896 421 6244267 SGTC_1564 D-Arginine 115 µM 1.58512472188127 0.0663567112386263 no 319 0.0564689998350681 393 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2210 7115885 190.385 µM 1.57861449247421 0.0671532920197349 no 320 0.0572122542237028 377 2927039 SGTC_1066 ketoconazole 628 nM 1.57455605214886 0.0676536050177775 no 321 0.05767947689134 437 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2536 dehydroabietamide 32.04 µM 1.57276285776942 0.0678755801401752 no 322 0.0578868694679265 415 3983547 SGTC_1759 st043059 70 µM 1.57014568052285 0.0682005630475984 no 323 0.0581906116497049 430 669426 SGTC_2043 5101342 149 µM 1.56906701517914 0.0683348531931901 no 324 0.0583161622989987 399 678451 SGTC_1214 0358-0031 63.7 µM 1.56798017209628 0.0684703677152808 no 325 0.0584428798910134 387 4301366 SGTC_1713 st033146 12.748 µM 1.55922429560141 0.0695696806694067 no 326 0.0594716511973583 392 674619 SGTC_3175 9106517 49.47 µM 1.55893107267377 0.0696067290419903 no 327 0.0595063474963592 370 41468073 SGTC_1043 0916-0009 19.3 µM 1.55183114863885 0.0705084403805965 no 328 0.0603513153736765 487 3101130 SGTC_51 1013-0126 23.419 µM 1.55015095580608 0.0707231380664751 no 329 0.0605526440659367 369 1627850 SGTC_1488 4013-0813 75.9 µM 1.54808376306306 0.0709879760387464 no 330 0.060801065397547 332 2910057 SGTC_3162 9099653 49.47 µM 1.54675090103972 0.0711591388616156 no 331 0.0609616619246407 324 25237511 SGTC_2128 5255449 168.493 µM 1.54535040765514 0.0713393279632469 no 332 0.0611307644413208 419 736008 SGTC_2312 7706453 155.7 µM 1.54215156632237 0.0717522079787107 no 333 0.0615183832641372 402 976098 SGTC_721 1187-1332 279 µM 1.5404538534442 0.0719720779779677 no 334 0.0617248814998684 288 25730 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.53953392651641 0.072091432888938 no 335 0.0618370009884732 394 688662 SGTC_1468 k284-1086 134 µM 1.5363940728185 0.0724999526970473 no 336 0.0622208797894467 485 15996457 SGTC_2588 indole-3-carbinol 100 µM 1.5329312255109 0.07295255033155 no 337 0.0626464006068725 457 3712 Induces cell cycle arrest. SGTC_2639 lactacystin 53 µM 1.52925072349168 0.0734359631800958 no 338 0.0631011501803799 432 3870 A proteasome inhibitor. SGTC_2262 9014885 67.46 µM 1.52579207229445 0.073892466384943 no 339 0.0635308278342961 288 6457424 SGTC_1153 4055-0057 267 µM 1.5223934198875 0.0743431597703328 no 340 0.0639552662987838 419 882706 SGTC_2066 5222451 176 µM 1.52143014251039 0.0744712804429162 no 341 0.0640759647368649 483 2281147 SGTC_588 3970-1144 52.9 µM 1.52096391484931 0.0745333515390281 no 342 0.0641344465217681 427 1888707 SGTC_2730 imipramine 71.33 µM 1.51287941270912 0.0756159691912746 no 343 0.0651551461026741 503 3696 A tricyclic antidepressant. SGTC_167 3672-0051 66.205 µM 1.5125742819927 0.0756570634728947 no 344 0.0651939154717358 388 3237971 SGTC_1741 st038134 10.228 µM 1.51186458067517 0.0757527101693188 no 345 0.0652841580980998 459 1272587 SGTC_2377 9073351 62.6 µM 1.50411571834015 0.0768030278425725 no 346 0.0662757868793813 410 7337946 YHR072W ERG7 SGTC_1995 st072814 61.1 µM 1.50062523400344 0.0772797462853077 no 347 0.0667262604304351 387 5769371 SGTC_378 3970-0959 8.33 µM 1.49989932578542 0.0773791701125724 no 348 0.0668202413356279 408 6615653 SGTC_155 k072-0202 43.6 µM 1.49946364106942 0.0774388901927126 no 349 0.0668766971369274 374 5857737 SGTC_673 1082-0474 110 µM 1.49903462232335 0.0774977307556145 no 350 0.0669323252170549 521 3098046 SGTC_1264 0783-0040 158 µM 1.49888008279087 0.0775189343993509 no 351 0.0669523721231603 394 2855798 SGTC_1306 1185-0270 9.02 µM 1.495522784552 0.077980661666044 no 352 0.0673890290478218 462 1548076 SGTC_1080 nisoldipine 24.4 µM 1.49089696692485 0.0786202620779562 no 353 0.0679942739149681 449 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_274 sirtinol 40.1 µM 1.48945065318974 0.0788210540398176 no 354 0.0681843692914791 422 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2347 9049783 174.81 µM 1.48812222013232 0.0790058227083844 no 355 0.0683593322705868 468 6467988 YPL169C MEX67 SGTC_1176 0848-0131 83.3 µM 1.48790902994838 0.0790355053586342 no 356 0.0683874429869419 472 6769040 SGTC_2205 7238770 200 µM 1.48487791199809 0.0794584446860098 no 357 0.0687880840594416 370 279867 SGTC_896 0964-0007 44.5 µM 1.48452041459804 0.0795084398845928 no 358 0.0688354557005106 415 6756758 SGTC_485 niflumic acid 177 µM 1.48317219579748 0.0796971994007055 no 359 0.0690143332020007 387 4488 A COX2 inhibitor. SGTC_1033 k072-0102 21.3 µM 1.48008949734008 0.0801300709932603 no 360 0.0694246820194387 454 5965931 SGTC_2276 7947513 42.08 µM 1.47510881564145 0.0808332088954952 no 361 0.0700916453743108 399 2105100 SGTC_3132 9126706 49.47 µM 1.47355001738914 0.0810542235057188 no 362 0.0703013937127524 398 850858 SGTC_2261 9010538 184.68 µM 1.47111062563907 0.0814010081596022 no 363 0.0706306009566011 362 6457250 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.46937011460589 0.0816491229922859 no 364 0.0708662143473048 478 688667 SGTC_891 0929-0073 133 µM 1.46700506365611 0.0819871809849944 no 365 0.0711873389382525 420 5603632 SGTC_834 0312-0008 75.7 µM 1.4649304957685 0.0822845849833413 no 366 0.0714699408037195 475 6385573 YIL048W NEO1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.46332198985948 0.0825157343157719 no 367 0.0716896466925374 435 7104 SGTC_1291 0993-0025 5.79 µM 1.46086397197404 0.0828699059762012 no 368 0.0720263877896632 435 4353356 SGTC_1341 1486-1360 280 µM 1.45439418586656 0.083807592171809 no 369 0.0729185254873795 468 3976547 SGTC_1441 4106-0040 13 µM 1.45167578649684 0.0842039474160857 no 370 0.0732958875075907 432 2904180 SGTC_3030 9087619 49.47 µM 1.44803784552752 0.0847365753002643 no 371 0.0738032333032738 428 25236973 SGTC_439 amiodarone 34.4 µM 1.44799013065281 0.0847435779421858 no 372 0.0738099053882435 528 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1367 1812-0510 76.9 µM 1.44275133046986 0.0855150671942743 no 373 0.0745452668891122 443 1142582 YDR527W RBA50 SGTC_2463 5473429 200 µM 1.43823213406014 0.0861847997978233 no 374 0.0751841002490463 415 5399405 SGTC_2484 5809818 12.04 µM 1.43128414392075 0.0872221146731711 no 375 0.0761743981871351 448 2870548 SGTC_3089 9117425 49.47 µM 1.42951853243403 0.0874871948241677 no 376 0.0764276261113263 442 9401657 SGTC_1663 st014140 55.4 µM 1.42420249540117 0.0882889483890883 no 377 0.0771939313770954 524 4207120 SGTC_2647 atorvastatin 60.16 µM 1.41989515794593 0.0889425778414674 no 378 0.0778191029049805 449 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_691 1548-0686 185 µM 1.41449759799742 0.0897667231510195 no 379 0.0786079260722476 495 46495133 SGTC_2580 diallyl disulphide 81.36 µM 1.41345505140126 0.0899265600744563 no 380 0.0787609843329593 441 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3123 9126162 49.47 µM 1.41070082775518 0.0903498382681899 no 381 0.0791664234060527 468 25239884 SGTC_1597 7-benzyloxygramine 47.5 µM 1.40987480196611 0.0904770725987439 no 382 0.0792883271353632 624 260807 SGTC_2424 5537928 59.2 µM 1.40502584718687 0.0912266499448672 no 383 0.0800067962157078 519 5382802 SGTC_1527 coumarin 137 µM 1.40401442880506 0.091383579158684 no 384 0.0801572764982115 441 323 A hepatotoxic, DNA x-linker. SGTC_96 0929-0093 37.281 µM 1.40147199005104 0.0917789413738042 no 385 0.0805364889134224 455 6991579 SGTC_1164 k060-0068 93.7 µM 1.40110486147655 0.0918361362789588 no 386 0.0805913590352855 522 5963676 SGTC_2488 5268135 45.7 µM 1.39784339570347 0.0923453990078691 no 387 0.081080049831202 590 1270356 YLR208W SEC13 SGTC_1701 st028638 40.4 µM 1.39687395320904 0.0924971751340477 no 388 0.0812257392416167 477 3490878 SGTC_496 calpeptin 138 µM 1.39601821859871 0.0926313024187886 no 389 0.0813545044883519 417 73364 A calpain inhibitor. SGTC_580 1123-0028 41 µM 1.38505960563774 0.0943616840437925 no 390 0.0830171210844595 552 1677248 YPR107C YTH1 SGTC_2144 5628481 200 µM 1.38141897202826 0.0949417882993446 no 391 0.0835750879166726 431 2818399 SGTC_1822 st052468 42 µM 1.381410080148 0.0949432083545689 no 392 0.0835764541355084 453 2873678 SGTC_3277 9138724 49.47 µM 1.37724612727923 0.0956099225002081 no 393 0.0842180824719876 370 15943418 SGTC_105 0111-0055 734.78 µM 1.37682967690271 0.095676791773776 no 394 0.0842824566179225 402 5179370 SGTC_126 0417-1624 672.48 µM 1.3765116982531 0.095727872643774 no 395 0.0843316340401572 615 41912 YDL195W SEC31 SGTC_2608 thymoquinone 42.66 µM 1.37130168330567 0.0965676817326154 no 396 0.085140465591447 442 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1137 ixabepilone 100 µM 1.36934889078618 0.0968838454088737 no 397 0.0854451210818463 561 154225 A novel microtubule stabilizer. SGTC_2940 9060638 45.86 µM 1.36763041158321 0.0971627010912322 no 398 0.0857138960838582 517 4027022 SGTC_1487 3970-0795 2.82 µM 1.36722497543129 0.0972285765484205 no 399 0.0857773996224508 511 3765103 SGTC_590 k048-0076 22.4 µM 1.36668397155857 0.097316530147221 no 400 0.085862191999745 492 6832814 SGTC_2401 5128683 200 µM 1.36541597043634 0.0975229038933408 no 401 0.0860611735848378 467 708373 SGTC_2101 5377231 179.231 µM 1.34914824489301 0.100199087977007 no 402 0.0886446773094082 485 2844213 SGTC_2073 5212005 126 µM 1.34460879891718 0.100955346018172 no 403 0.0893758001872897 410 691789 SGTC_456 gingerol 170 µM 1.33943724029211 0.101821972925564 no 404 0.0902141863959173 510 442793 A herb. SGTC_1393 3470-5649 58.2 µM 1.3392740884601 0.101849401028833 no 405 0.090240730454005 413 4108395 SGTC_616 4092-0450 108 µM 1.33399344656645 0.102740056685913 no 406 0.0911030021439618 546 787165 SGTC_2955 9076254 12.21 µM 1.33297507396006 0.102912468855022 no 407 0.091269991907181 478 16459619 SGTC_2357 9067248 200 µM 1.33035098698457 0.103357699580309 no 408 0.0917013276493333 481 9150235 SGTC_928 2764-0428 58.7 µM 1.32967512172612 0.103472600252384 no 409 0.0918126675681286 556 662578 SGTC_1768 st044301 37.178 µM 1.32961689137159 0.103482504057081 no 410 0.0918222649370464 541 3931349 SGTC_65 0798-0905 34.986 µM 1.32736738414356 0.103865626531428 no 411 0.0921935916895401 635 3602145 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.31775883831417 0.105513678991006 no 412 0.0937921955325315 561 165521 SGTC_2474 5321570 43.32 µM 1.3149269661792 0.106002989190366 no 413 0.0942672244576701 510 2841384 SGTC_1849 st056239 19.2 µM 1.31298636702274 0.106339244614245 no 414 0.0945937710261372 561 5393181 SGTC_625 k213-0058 121 µM 1.31252115141958 0.106419968733438 no 415 0.0946721770859559 733 3655420 SGTC_546 peri-Naphthalide 147 µM 1.30589885966165 0.107573868451905 no 416 0.0957934772236239 544 223824 A penicillin ester. SGTC_592 k241-0073 46.5 µM 1.30400359260525 0.107905762122113 no 417 0.0961161787261497 570 4230158 SGTC_72 0744-0168 198.391 µM 1.30293418719807 0.108093358421833 no 418 0.0962986155614927 533 677577 SGTC_340 k038-0059 454 µM 1.30206727012969 0.108245606221178 no 419 0.0964466952749463 552 23733424 SGTC_1403 3909-7815 62.9 µM 1.30097012573453 0.108438507681264 no 420 0.0966343403200039 486 6615483 SGTC_1863 st057641 20.1 µM 1.3007176123546 0.108482939928781 no 421 0.0966775657214956 574 3921635 SGTC_1622 st003707 19.4 µM 1.29755442435504 0.109040644426145 no 422 0.0972202459317614 585 10140899 SGTC_1457 k015-0032 57.3 µM 1.29433470812536 0.10961042868807 no 423 0.0977749163565375 551 4302660 SGTC_1296 1068-0102 11.9 µM 1.29088411506307 0.11022344037511 no 424 0.0983719321999968 549 767053 SGTC_2024 5144227 134 µM 1.2900610504041 0.110370023626782 no 425 0.0985147309797523 593 3475211 SGTC_1052 3253-3998 198 µM 1.28471331749913 0.111325830396566 no 426 0.0994462413877986 603 5450317 SGTC_364 0083-0097 67.7 µM 1.28435918153099 0.111389334081354 no 427 0.0995081541115685 553 5207356 SGTC_2878 9043973 25.97 µM 1.28385299677922 0.111480148173128 no 428 0.0995966980558506 517 6465167 SGTC_3 0833-0587 95.581 µM 1.28247850954291 0.11172701077489 no 429 0.0998374194837637 550 5382644 SGTC_655 k060-0012 42 µM 1.28087199325976 0.112016041911614 no 430 0.100119315742147 564 5994525 SGTC_3086 9117350 49.47 µM 1.27891076568301 0.112369613928981 no 431 0.100464240558022 450 2679265 SGTC_1149 3909-7961 23.3 µM 1.27765890397759 0.112595717307695 no 432 0.100684860728077 550 735261 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.27705829256052 0.112704311230348 no 433 0.100790834025027 535 616764 SGTC_842 0271-0008 11.1 µM 1.27691994914529 0.112729335091867 no 434 0.100815255185038 602 1221709 SGTC_3105 9121040 49.47 µM 1.27612545712645 0.112873121373701 no 435 0.100955586942848 321 41448907 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.27565847089892 0.112957697090176 no 436 0.101038137513774 512 279621 SGTC_1948 st076329 66.6 µM 1.27390517708209 0.113275639231667 no 437 0.101348511716892 516 24208413 SGTC_1345 1488-0192 31.4 µM 1.27376221474292 0.11330159213053 no 438 0.10137385000354 569 658348 SGTC_3236 9132701 49.47 µM 1.27312923657007 0.113416551808494 no 439 0.101486092918759 552 24282524 SGTC_3282 9108498 15.4605 µM 1.2681023291074 0.114332478633534 no 440 0.102380704946228 566 16459645 SGTC_775 4577-0580 57.3 µM 1.26794331783338 0.114361536940742 no 441 0.102409096611693 580 2006902 SGTC_442 cape 100 µM 1.26703709595219 0.114527243651465 no 442 0.102571012979414 515 5281787 SGTC_1275 0867-0008 21.1 µM 1.26296587660828 0.115273792662081 no 443 0.103300721616977 565 3422836 SGTC_1776 st049249 45.9 µM 1.26144824550927 0.115552967384701 no 444 0.103573697677751 590 1822314 SGTC_1389 3405-0187 19 µM 1.25990657833554 0.115837055140426 no 445 0.103851532687356 520 799890 SGTC_866 0495-0101 262 µM 1.25331968931615 0.117056427111884 no 446 0.105044692855448 549 635694 SGTC_1676 st018489 23.4 µM 1.25260766255384 0.117188780976977 no 447 0.105174262429786 582 3696235 SGTC_1128 3448-9350 235 µM 1.25171322227203 0.117355192649165 no 448 0.105337190161398 520 619386 SGTC_2269 7935389 174.42 µM 1.25046078604349 0.117588491017277 no 449 0.10556563575374 578 97605 SGTC_1362 1611-0397 101 µM 1.24991779154317 0.117689739629069 no 450 0.105664789737806 582 27816 SGTC_38 0929-0051 58.268 µM 1.24760706581562 0.118121295405215 no 451 0.106087494811921 630 1379719 SGTC_1276 0871-0068 94.2 µM 1.23875751365743 0.119784402159008 no 452 0.107717656162821 549 3414906 SGTC_2556 citropten 84.59 µM 1.238573771105 0.119819107204258 no 453 0.107751693251955 634 2775 A potential DNA crosslinker. SGTC_2670 beta-carotene 100 µM 1.236685542527 0.120176164087194 no 454 0.108101924053559 498 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1035 k081-0041 55.2 µM 1.23148170353879 0.121164068545697 no 455 0.109071377796924 634 731709 SGTC_261 5-fluorouridine 15.376 µM 1.22999193376251 0.121447937416479 no 456 0.109350062718533 604 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_472 calcifediol 10 µM 1.22911655758818 0.121614954287816 no 457 0.109514054017134 518 5283731 A vitamin D metabolite. SGTC_385 1494-0393 12.4 µM 1.22856090680672 0.121721053060317 no 458 0.109618240163121 609 3090647 SGTC_487 nimodipine 119 µM 1.22578352945776 0.122252354554817 no 459 0.110140073450839 481 4497 L-type voltage-gated calcium channels inhibitor SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.22514658494713 0.122374428707536 no 460 0.110259997871121 637 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1151 3909-8316 15.3 µM 1.22273369639272 0.122837648768025 no 461 0.110715147733552 611 800431 SGTC_2114 5491910 81.25 µM 1.22088679659699 0.123193041585492 no 462 0.111064442135048 613 2849228 SGTC_2125 5246583 200 µM 1.21886324781358 0.123583252946203 no 463 0.111448050476373 701 835267 SGTC_1758 st042942 75.2445 µM 1.21831583538408 0.123688961901644 no 464 0.111551987351007 598 669317 SGTC_779 1360-0071 233 µM 1.21774665221053 0.123798942051786 no 465 0.111660131356385 652 7566 SGTC_230 MPP+ 141.667 µM 1.21246710319461 0.124822343424812 no 466 0.112666813924246 576 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1133 3473-0247 50 µM 1.21119770059549 0.125069286734636 no 467 0.112909821905509 643 711311 SGTC_3238 9133470 49.47 µM 1.20878029539764 0.125540499957801 no 468 0.113373631867548 593 3534688 SGTC_1162 k048-0130 20.1 µM 1.2070579190461 0.125876989447832 no 469 0.11370491965786 622 6797406 SGTC_2680 butyl paraben 22.24 µM 1.20620424541032 0.126043999056149 no 470 0.113869373700903 573 7184 An antifungal and steroid mimetic. SGTC_924 2046-0044 21.3 µM 1.20556043408991 0.126170054109568 no 471 0.113993511355604 615 3623589 SGTC_3320 9137005 35.139 µM 1.20253727475629 0.12676314866121 no 472 0.114577716687443 587 4908713 SGTC_1340 1486-1359 257 µM 1.20183209272661 0.126901772642906 no 473 0.114714294353748 634 4309068 SGTC_3033 9090887 49.47 µM 1.19809835111394 0.127637506267039 no 474 0.115439365351933 646 19325384 SGTC_596 1155-0152 116 µM 1.19799025099222 0.127658851469959 no 475 0.115460406169481 675 280313 SGTC_622 1348-1566 26.3 µM 1.19784921657987 0.127686703533086 no 476 0.115487861478131 687 7340407 SGTC_2353 9059630 146.67 µM 1.19695126270632 0.12786413426622 no 477 0.115662775843892 598 4779114 SGTC_1206 3978-0017 132 µM 1.19670739845689 0.127912350065831 no 478 0.115710311161352 580 3873677 SGTC_130 0136-0219 337.655 µM 1.19169270750457 0.128906635034502 no 479 0.116690879267487 656 234244 SGTC_1789 tunicamycin 25 nM 1.18894908953918 0.129452887233376 no 480 0.11722985062558 628 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2428 5615643 7.78 µM 1.18741915237162 0.12975819212516 no 481 0.117531164562463 598 2253075 SGTC_2807 7945238 51.95 µM 1.18710935763602 0.129820073521418 no 482 0.117592243873327 642 17148797 SGTC_1173 0443-0020 122 µM 1.18648192263359 0.129945466051459 no 483 0.11771601815672 628 5331295 SGTC_3155 9099265 49.47 µM 1.18371189584528 0.130500056379481 no 484 0.11826356418275 584 25236499 SGTC_578 3460-0051 92 µM 1.18013065851434 0.131219483195212 no 485 0.118974126298439 706 2876744 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.17951027520203 0.131344388446132 no 486 0.119097523796809 669 2333 A French combination drug. SGTC_2029 5175081 200 µM 1.17566105442049 0.132121208441311 no 487 0.119865173657737 683 1380876 SGTC_1419 3993-2473 62.6 µM 1.17181487205432 0.132900573591159 no 488 0.120635695219533 660 704026 SGTC_451 chloral hydrate 100 µM 1.16783718852148 0.133709908784782 no 489 0.121436222123691 703 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1949 st076024 69.1 µM 1.16729865433081 0.133819743666961 no 490 0.121544890957185 620 2921930 SGTC_1757 st041620 31.8375 µM 1.16555227076485 0.134176347856178 no 491 0.121897757432235 660 5289815 SGTC_281 1672-3440 14.9 µM 1.16139208235607 0.135028468667324 no 492 0.122741243691593 712 6833000 SGTC_3308 9128332 17.569 µM 1.15788653657479 0.13574937618152 no 493 0.123455171238095 749 17332805 YDL196W YDL196W SGTC_418 lividomycin a 100 µM 1.15658312911973 0.136018090034872 no 494 0.123721359150027 711 72394 An antibiotic. SGTC_2324 6149169 200 µM 1.15513524349938 0.136317016533326 no 495 0.124017523887555 619 2888231 SGTC_2861 9024595 19.48 µM 1.1548325255051 0.136379571629613 no 496 0.124079507450836 542 16482810 SGTC_2521 angolensin 13.4 µM 1.1540486222813 0.136541652407781 no 497 0.124240117685908 614 821428 A flavenoid. SGTC_1263 0774-1208 64.8 µM 1.15394354334562 0.136563388664408 no 498 0.124261657861497 746 906585 SGTC_1440 4100-1550 40 µM 1.15070663512588 0.137234123388185 no 499 0.124926472959789 633 742806 SGTC_2346 9031566 143.75 µM 1.15037693433442 0.137302568264818 no 500 0.124994328010284 673 4771086 SGTC_2061 5245884 80.95 µM 1.14979433790574 0.137423570489741 no 501 0.125114293930073 671 573863 SGTC_251 melphalan 456.522 µM 1.14924099300108 0.137538564726191 no 502 0.125228310928216 746 460612 A DNA alkylator. SGTC_3076 9116187 49.47 µM 1.14885537762034 0.137618740817378 no 503 0.12530781005617 601 27241210 SGTC_2470 5664817 21.68 µM 1.14869887251654 0.137651290027846 no 504 0.1253400854664 667 2859561 SGTC_2619 obliquin 87.91 µM 1.14640294194379 0.13812939103019 no 505 0.125814232993883 744 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3271 9137798 49.47 µM 1.14634727497397 0.138140997076074 no 506 0.12582574465454 589 6498326 SGTC_506 n9-isopropylolomoucine 153 µM 1.1433929911366 0.138757891982922 no 507 0.126437730597519 674 6610355 SGTC_1660 st012960 28.1 µM 1.13777641659136 0.139935877488031 no 508 0.127606927488971 651 24207266 SGTC_1966 st070145 16.1 µM 1.13736211194312 0.140023039532077 no 509 0.127693469599457 661 3748532 SGTC_237 nikkomycin 200 µM 1.13433172620721 0.140661698348666 no 510 0.128327712916739 697 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1787 fluconazole 80 µM 1.13314725868995 0.140911863387928 no 511 0.128576209094746 717 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_75 0159-0059 199.013 µM 1.13280302613259 0.140984623470163 no 512 0.128648490188611 645 5377270 SGTC_925 2064-1272 59.6 µM 1.13193701291554 0.141167784473314 no 513 0.128830458164635 634 6815817 SGTC_2179 6298986 200 µM 1.13100995263229 0.141364035602823 no 514 0.12902545122102 657 738374 SGTC_205 1486-1330 71.903 µM 1.12896490754206 0.141797608656723 no 515 0.129456318814934 627 4118834 SGTC_811 0416-0114 265 µM 1.1266557307312 0.142288262180531 no 516 0.129944033147476 658 6612453 SGTC_2018 5133068 143 µM 1.12359698219234 0.142939951244543 no 517 0.130592018471845 650 785362 SGTC_847 0342-0274 5.54 µM 1.11909451384788 0.14390290008956 no 518 0.131549910041314 713 18097 SGTC_1460 k062-0059 9.15 µM 1.11861036565243 0.144006705461868 no 519 0.131653199686105 680 1373085 SGTC_1931 st074438 57.1 µM 1.1183352950653 0.144065705359532 no 520 0.131711909005462 650 2787313 SGTC_3068 9116768 49.47 µM 1.11658767571392 0.144440933020146 no 521 0.13208533176556 625 41904888 SGTC_349 k015-0014 24 µM 1.11542176712976 0.144691628710557 no 522 0.132334863019635 639 2196908 SGTC_380 3970-0968 6 µM 1.11458348005491 0.144872059661712 no 523 0.132514476401407 665 2891601 SGTC_2275 7947463 200 µM 1.11411705911202 0.14497251658376 no 524 0.132614485557692 657 1225414 SGTC_3122 9126309 49.47 µM 1.11249501626855 0.145322234354187 no 525 0.132962685887518 678 17591206 SGTC_530 4358-1714 28 µM 1.10976754695841 0.145911564264242 no 526 0.133549603609287 755 1564641 SGTC_2853 9015042 58.44 µM 1.10830360392879 0.146228542889528 no 527 0.133865359782851 646 6457456 SGTC_788 1182-0090 188 µM 1.10797892037791 0.146298907242906 no 528 0.133935459864427 809 5715185 SGTC_56 0957-0365 83.25 µM 1.10627544505238 0.146668451351026 no 529 0.134303658273202 714 6752360 SGTC_789 1309-1135 70.6 µM 1.10449531779492 0.147055292708784 no 530 0.134689166760477 699 3092424 SGTC_2626 ethyl orsellinate 100 µM 1.10410470072829 0.147140269571327 no 531 0.134773861197747 655 75653 A natural product. SGTC_1661 st013063 9.66 µM 1.1040005928144 0.147162923302084 no 532 0.134796440267009 756 721395 SGTC_2595 hexamethylquercetagetin 100 µM 1.10052184428052 0.147921238417955 no 533 0.135552408661917 660 386331 SGTC_1690 st023502 41.2 µM 1.09762893322496 0.148553838450435 no 534 0.136183276721931 685 24207482 SGTC_680 0417-1641 114 µM 1.09707510657654 0.148675151088872 no 535 0.136304280584895 664 2835990 SGTC_1024 4507-0395 26 µM 1.09489123474002 0.1491541613107 no 536 0.136782144790682 679 4201836 SGTC_190 3970-0790 3.722 µM 1.09413473988012 0.149320330907392 no 537 0.136947944065765 684 2832352 SGTC_2808 7946468 45.46 µM 1.09387225573392 0.149378016330537 no 538 0.137005504206413 747 2970879 SGTC_2610 ononetin 44.17 µM 1.09236843942212 0.149708792672089 no 539 0.137335594687489 717 259632 SGTC_694 1315-0438 43.2 µM 1.09183615417392 0.149825990043802 no 540 0.137452562323613 614 6793154 SGTC_627 1391-0720 175 µM 1.08916255781281 0.150415581928257 no 541 0.138041103502709 686 997839 SGTC_1752 st044819 83.042 µM 1.08778349054899 0.150720302707705 no 542 0.138345349742577 679 441209 YML126C ERG13 SGTC_1076 itraconazole 331 nM 1.08747313979723 0.150788934898213 no 543 0.138413881476483 732 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1302 1159-0335 255 µM 1.08387413685895 0.151586352189498 no 544 0.139210304167085 701 649284 SGTC_2614 arthonioic acid 13.39 µM 1.08309801344393 0.15175868165195 no 545 0.139382460328678 661 6710684 SGTC_3279 9140807 49.47 µM 1.08231984127918 0.151931596670804 no 546 0.139555216286747 726 45595718 SGTC_2135 5326629 150.42 µM 1.08144121828742 0.152126989785378 no 547 0.139750447513001 652 5020077 SGTC_2418 pentamidine 31.67 µM 1.07973325978827 0.152507292455347 no 548 0.140130489284896 678 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1309 pyrazolanthrone 13.4 µM 1.07970450160298 0.152513701294161 no 549 0.140136894339553 773 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.07776226512692 0.152946947518231 no 550 0.140569931717337 741 442882 SGTC_1349 flufenamic acid 69 µM 1.07738850687012 0.153030413672565 no 551 0.140653368256069 703 3371 A non-steroidal anti-inflammatory. SGTC_1437 4092-1038 11.6 µM 1.07633761919698 0.153265255351281 no 552 0.140888144976079 765 3977136 SGTC_1960 st011366 51.8 µM 1.0731596902657 0.153976878774544 no 553 0.141599736597016 722 3972846 SGTC_2290 7904846 200 µM 1.07273724970565 0.154071638897552 no 554 0.141694511156079 723 2962154 SGTC_1825 st052143 62.6 µM 1.07243916218622 0.154138527871633 no 555 0.141761412955926 703 674173 SGTC_1683 st010134 710 nM 1.07132207813527 0.154389365394909 no 556 0.142012317982134 723 3818134 SGTC_146 3448-8650 53.125 µM 1.0700251373945 0.154680927519418 no 557 0.142303997011643 862 2891488 YIL048W NEO1 SGTC_2813 7971799 71.43 µM 1.06982752188855 0.154725384907019 no 558 0.142348475850522 709 2234054 SGTC_2831 7999036 19.48 µM 1.06855361011935 0.15501217833904 no 559 0.142635430682082 774 2988270 SGTC_1058 3448-5425 97.3 µM 1.06843274964849 0.155039405656728 no 560 0.14266267539214 701 7279705 SGTC_2003 4023581 200 µM 1.06782356170748 0.155176690935815 no 561 0.14280005382708 700 16641307 SGTC_1609 st001574 46.4 µM 1.06702491518221 0.155356793724629 no 562 0.142980292632713 742 3960012 SGTC_3178 9107506 49.47 µM 1.06649538962778 0.15547628306071 no 563 0.143099880845616 736 8897194 SGTC_3232 9132874 49.47 µM 1.06551128904284 0.155698509891351 no 564 0.143322309862364 703 3784940 SGTC_1614 st002383 48.6 µM 1.06462874550537 0.155897981471419 no 565 0.14352198316061 737 1947235 SGTC_2589 lobaric acid 100 µM 1.05863679725621 0.157256728314247 no 566 0.144882610940041 715 73157 A novel microtubule depolymerizer. SGTC_89 0302-0250 142.109 µM 1.0584058170724 0.15730926125716 no 567 0.1449352342781 796 4203518 YLR208W SEC13 SGTC_141 0443-0274 32.331 µM 1.05787094309771 0.157430954523414 no 568 0.145057141979237 848 1627241 SGTC_538 2922-0838 53.3 µM 1.057124813604 0.157600815478089 no 569 0.145227313990658 825 777039 SGTC_1086 cerivastatin 2.18 µM 1.05639704287032 0.157766612914164 no 570 0.145393428225266 717 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2183 6420625 130.508 µM 1.05463448214538 0.15816862606314 no 571 0.145796263490433 800 2897619 SGTC_1907 st060210 83.7 µM 1.05036278538217 0.159145721524955 no 572 0.146775674379599 829 688793 SGTC_1832 st054113 55 µM 1.04961962120904 0.159316113650205 no 573 0.146946516128974 734 1251267 SGTC_26 0302-0163 425.158 µM 1.04773706915786 0.159748278174266 no 574 0.147379881833618 757 3100915 SGTC_3026 9090633 49.47 µM 1.04742147753831 0.159820801369364 no 575 0.147452615134227 755 25236842 SGTC_2200 6600604 21.907 µM 1.04711774954363 0.159890618630379 no 576 0.147522636974128 775 2904777 SGTC_1724 st037281 8.293 µM 1.04489822431029 0.160401421285745 no 577 0.148035005285668 739 574124 YDL195W SEC31 SGTC_1507 4075-3230 155 µM 1.04092404687378 0.161318701490472 no 578 0.148955400149312 685 659771 SGTC_2628 lathosterol 100 µM 1.04070657185783 0.161368995459396 no 579 0.149005876109529 767 6710616 SGTC_102 gallobenzophenone 83.616 µM 1.0315258277552 0.163501490099549 no 580 0.151147151425492 769 70837 SGTC_1026 k007-1105 30.6 µM 1.02872911325452 0.164154728641863 no 581 0.151803492640514 820 7066794 SGTC_686 1319-0111 510 µM 1.0285005613784 0.164208187032356 no 582 0.151857213449923 808 4562600 SGTC_1531 st059297 52.4 µM 1.02637963581713 0.164704810947407 no 583 0.152356336549073 793 7566702 SGTC_3285 9112818 20.8695 µM 1.02388875238507 0.165289303267998 no 584 0.1529439116919 827 17017947 YPR165W RHO1 SGTC_8 0354-0001 70 µM 1.0220345543524 0.165725266080415 no 585 0.153382273123096 876 4993152 SGTC_900 1112-0045 141 µM 1.01751967841752 0.166789918961845 no 586 0.154453137900497 654 56211 YIL048W NEO1 SGTC_2834 9001755 58.44 µM 1.01573608837779 0.167211720569827 no 587 0.154877538930186 713 2989575 SGTC_318 1488-0629 67.2 µM 1.01275786409579 0.167917572803908 no 588 0.155587915732233 755 3662576 SGTC_2816 7982706 58.44 µM 1.00926985491223 0.168746681176149 no 589 0.15642261657114 750 2981853 SGTC_945 3381-0768 11.3 µM 1.00188396324216 0.170510993049637 no 590 0.158199819395993 842 1126236 YIL048W NEO1 SGTC_760 0568-0725 82.9 µM 1.00140300325817 0.170626291012713 no 591 0.158316006366278 859 3916171 SGTC_2010 4012422 159 µM 1.00108556814553 0.170702415368543 no 592 0.158392720796931 801 952393 SGTC_1064 honokiol 6.76 µM 0.999357141882614 0.171117291949294 no 593 0.158810856775085 815 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1328 1441-0025 69.2 µM 0.999164314571232 0.171163616511012 no 594 0.15885754983268 755 4562601 SGTC_18 0111-0177 500 nM 0.997750526952411 0.17150350778086 no 595 0.159200172755591 891 721752 SGTC_897 1000-0139 31.4 µM 0.995628166233242 0.172014557558763 no 596 0.159715422092923 799 6151020 SGTC_515 4092-1064 102 µM 0.994317626236508 0.172330611498798 no 597 0.160034128548269 868 717353 SGTC_1227 3909-8010 46.6 µM 0.990052945395978 0.1733616576665 no 598 0.161074120506043 795 15982272 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.989091851419979 0.173594556690215 no 599 0.161309102031069 781 115019 SGTC_512 prima-1 270 µM 0.988001567678617 0.173859002798299 no 600 0.161575940214927 843 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3321 9137793 26.8275 µM 0.985993728894763 0.174346669961726 no 601 0.162068095100122 820 4904192 SGTC_3200 9114385 49.47 µM 0.984460037814093 0.174719760224283 no 602 0.162444685467544 750 17018030 YLR208W SEC13 SGTC_1249 0481-0015 10.2 µM 0.98394741512119 0.174844575282566 no 603 0.162570684353086 758 4227577 SGTC_2071 5230951 39.92 µM 0.983568139515409 0.174936958968937 no 604 0.162663948421721 863 1799272 SGTC_2914 7968218 45.32 µM 0.983330588361802 0.174994837285433 no 605 0.162722380096835 774 2977111 SGTC_2199 6590217 200 µM 0.981750953244219 0.175380017548612 no 606 0.16311127823012 754 703109 SGTC_3231 9132313 49.47 µM 0.981145835849791 0.175527712435094 no 607 0.163260414950288 823 4905967 SGTC_1232 0279-0259 161 µM 0.979950862529695 0.175819608712762 no 608 0.163555187213706 815 1560000 SGTC_1662 st014054 52 µM 0.979349193388629 0.175966694815904 no 609 0.163703735798077 802 2838777 SGTC_375 3970-0961 9.27 µM 0.973271132971592 0.177456925110466 no 610 0.165209282760098 835 2898222 SGTC_3012 9080433 71.4286 µM 0.972109449769612 0.177742653033528 no 611 0.165498050740837 868 17688859 SGTC_970 1315-0089 19.5 µM 0.971634108437499 0.177859651752108 no 612 0.16561630383918 772 6811083 YLR033W RSC58 SGTC_1067 clotrimazole 1.36 µM 0.971279861448425 0.177946876348879 no 613 0.165704467203729 843 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3245 9134821 49.47 µM 0.967491149617562 0.178881439771821 no 614 0.166649281744945 847 17014901 SGTC_1122 capsaicin 818.572 nM 0.964702924041866 0.179571182292165 no 615 0.167346815133209 858 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_416 estradiol valerate 100 µM 0.962930528642518 0.180010499688916 no 616 0.167791193936876 825 13791 A steroid. SGTC_3317 9138495 8.753 µM 0.961348836053188 0.180403117588498 no 617 0.168188400274018 849 17020139 SGTC_751 0833-0568 350 µM 0.959882040607388 0.180767694723126 no 618 0.168557292961175 839 6954252 SGTC_2767 sibutramine 71.45 µM 0.959514934071366 0.180859012552406 no 619 0.168649699982846 870 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2568 diosmetin 100 µM 0.956173610931272 0.181691496158589 no 620 0.169492264940622 870 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_516 3992-2719 87.3 µM 0.955916699053362 0.181755604318927 no 621 0.169557160774971 803 5350887 YDR037W KRS1 SGTC_235 0330-0087 5 mM 0.955567548534664 0.181842751805679 no 622 0.16964538160274 887 46494818 YHR062C RPP1 SGTC_730 1436-0052 41.2 µM 0.955463214471402 0.181868798514742 no 623 0.169671749692098 821 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3338 9144300 39.5675 µM 0.955348319326516 0.181897484468102 no 624 0.169700789898745 853 4901274 SGTC_2635 hydroquinidine 100 µM 0.954607192550118 0.182082590113889 no 625 0.169888189249728 847 442912 An experimental heart treatment. SGTC_3240 9133527 49.47 µM 0.953929056227525 0.182252066245963 no 626 0.170059777201243 819 17617455 SGTC_2213 7173844 200 µM 0.950416336126388 0.18313152315806 no 627 0.170950373263158 865 892728 SGTC_1180 1193-0155 285 µM 0.949431473029755 0.183378571301149 no 628 0.17120060473927 793 2921347 SGTC_2791 5663188 71.43 µM 0.948609770500292 0.183584850326042 no 629 0.171409559931345 826 54690634 SGTC_2666 tannic acid 100 µM 0.945556431577252 0.184352622419601 no 630 0.172187437563239 888 16134267 A thiamine antagonist. SGTC_1134 3477-0009 42.5 µM 0.945540710209209 0.184356580771673 no 631 0.172191448605911 894 3973534 SGTC_2298 7976326 193.81 µM 0.944212247809965 0.184691254237749 no 632 0.172530598827329 797 2235818 SGTC_2096 5468907 200 µM 0.943834488644442 0.184786490313475 no 633 0.172627116706792 872 759785 SGTC_2064 5220758 200 µM 0.943405284467647 0.184894733120964 no 634 0.172736820611722 888 788518 SGTC_815 1582-0027 36.9 µM 0.942794340324648 0.185048877643065 no 635 0.172893053594585 869 3128206 SGTC_1526 st051518 75 µM 0.940843267826684 0.185541678192429 no 636 0.173392592067682 785 673993 SGTC_1183 1254-0324 198 µM 0.939938044127372 0.185770595310842 no 637 0.173624670704176 864 5799357 SGTC_624 k048-0052 28 µM 0.939806525454543 0.185803868925361 no 638 0.173658405517858 825 6835531 SGTC_1136 pergolide 1.05886 µM 0.938563748973198 0.186118468085017 no 639 0.173977386138831 895 47811 A dopamine receptor agonist. SGTC_1762 st045503 25.4615 µM 0.935110081149806 0.186994469407399 no 640 0.17486578586678 878 4645554 SGTC_2806 7952793 58.44 µM 0.93327046557407 0.187462115911105 no 641 0.175340170102865 868 2972490 SGTC_2866 9034245 58.44 µM 0.933097944800159 0.187506009254528 no 642 0.175384700086148 871 6462273 SGTC_1873 rapamycin 2 nM 0.928197040342449 0.188755566405414 no 643 0.17665268470585 903 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2737 bleomycin 30.5 nM 0.926992748214179 0.189063402017585 no 644 0.176965149730661 924 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2049 5262831 67.185 µM 0.92365278228911 0.189918765426942 no 645 0.177833561658963 869 763417 SGTC_1194 1488-0194 225 µM 0.923228612448993 0.190027565087502 no 646 0.177944040503034 898 1391452 SGTC_477 mead ethanolamide 10 µM 0.922473187326627 0.190221426647582 no 647 0.178140904917102 760 16061185 SGTC_1972 st070201 17.4 µM 0.922466085270062 0.190223249794723 no 648 0.178142756370129 897 2829099 SGTC_3094 9117742 49.47 µM 0.92160665907719 0.190443949700544 no 649 0.17836689189157 955 17149698 SGTC_905 2-aminofluorene 215 µM 0.92063097691319 0.190694694536918 no 650 0.178621561844372 936 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2059 5238311 157 µM 0.919547566465672 0.190973362228211 no 651 0.178904618901269 855 703021 SGTC_946 3434-1334 87.4 µM 0.919172938958922 0.191069779533919 no 652 0.179002561545632 866 4047976 SGTC_929 2805-0021 398 µM 0.918442688533685 0.191257808752079 no 653 0.1791935752331 868 3098024 SGTC_2819 7996655 46.38 µM 0.917488056651227 0.191503784031314 no 654 0.17944347428676 782 6456960 SGTC_2664 lyso-paf C-16 73.48 µM 0.913999197860243 0.192404388359269 no 655 0.18035863359477 935 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1503 4585-0012 61.3 µM 0.913628315158337 0.192500279039958 no 656 0.180456091400277 890 2922052 SGTC_597 k018-0003 82.8 µM 0.913491777595184 0.192535587799585 no 657 0.180491978046407 984 6786234 SGTC_3355 9151058 44.0485 µM 0.913448558795788 0.192546765052102 no 658 0.180503338327584 893 17015728 SGTC_976 1348-1067 47.6 µM 0.912466210334546 0.192800927116081 no 659 0.180761674559518 973 5310671 YGL099W LSG1 SGTC_227 fluconazole 33.516 µM 0.911421748934611 0.193071384295876 no 660 0.181036599240528 913 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3235 9132602 49.47 µM 0.910099672479346 0.19341406026505 no 661 0.181384973642808 912 4912240 SGTC_613 3914-0030 117 µM 0.909332674653766 0.193613032450469 no 662 0.181587274032553 686 1145395 SGTC_1644 st010134 20.9 µM 0.908469720835121 0.193837046409615 no 663 0.181815052140619 889 3818134 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.907481639190521 0.194093736187265 no 664 0.182076077319238 886 756377 SGTC_2760 etidronate 98.04 µM 0.905761506392968 0.194541096361232 no 665 0.182531049775498 864 3305 A chelator and antioxidant. SGTC_3295 9122362 53.5725 µM 0.902633445999135 0.195356227061901 no 666 0.183360234752893 855 4730473 SGTC_3330 9141424 71.43 µM 0.901584100795577 0.195630136484126 no 667 0.183638919992553 956 27261020 SGTC_2361 9034121 116 µM 0.901035855620222 0.195773337006676 no 668 0.183784627933422 878 6496917 SGTC_1258 0671-0043 57.1 µM 0.898506405438758 0.196434847736608 no 669 0.184457815915949 906 4298767 SGTC_2473 5854593 8.94 µM 0.897705131208595 0.196644682002981 no 670 0.184671386573003 878 2872951 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.896865995904266 0.196864576660441 no 671 0.184895213416278 951 23847180 SGTC_2657 nystatin 74.44 µM 0.896150962583473 0.197052067935643 no 672 0.185086070878823 936 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.894972580773279 0.19736129107313 no 673 0.185400872743818 978 16623 A steroid. SGTC_3327 9140648 26.9345 µM 0.893512161955875 0.197744931474744 no 674 0.185791481046491 918 8029710 SGTC_836 0330-0104 1.35 µM 0.893272691043956 0.197807881554881 no 675 0.185855579382774 907 46494820 SGTC_2368 9071271 200 µM 0.89287647980781 0.197912060785755 no 676 0.185961661963213 882 27209959 SGTC_2271 7849410 118.62 µM 0.89227299114948 0.198070804926321 no 677 0.18612331364075 917 972430 SGTC_1091 telmisartan 47.6 µM 0.890543887651727 0.198526060978589 no 678 0.186586956836657 933 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1216 1165-0504 9.65 µM 0.890205266779728 0.198615290399383 no 679 0.186677838579462 943 6304004 SGTC_1879 gemcitabine 100 µM 0.886745761555659 0.19952828400955 no 680 0.187607897417761 920 60750 A nucleoside analog which inhibits DNA replication. SGTC_272 doxorubicin 8.13 µM 0.886007983011526 0.199723316492197 no 681 0.18780661272548 992 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1733 st037357 54.9 µM 0.884464672085291 0.20013166296085 no 682 0.188222712513767 899 1272339 YGL099W LSG1 SGTC_2768 sulfasalazine 50.2 µM 0.883862796752203 0.200291049786048 no 683 0.18838514119892 945 5384001 An antioxidant and salicylic acid derivative. SGTC_1891 st059073 26.2 µM 0.883797901631093 0.200308239671804 no 684 0.188402659670954 1013 688754 SGTC_1838 st055369 84.5 µM 0.881261307720133 0.200980845135082 no 685 0.189088201581716 953 676036 SGTC_2483 5729050 27.16 µM 0.879315606940525 0.20149768592253 no 686 0.189615088019052 1005 2865180 SGTC_1804 st050076 49.1 µM 0.879112694148991 0.2015516319155 no 687 0.189670087788509 929 3895976 SGTC_1697 st025554 27.742 µM 0.878584377744217 0.201692129658035 no 688 0.18981333464989 905 1269519 SGTC_3190 9110366 49.47 µM 0.878494229442557 0.201716109090165 no 689 0.189837783958142 858 17123768 SGTC_1102 cgs 12066b 26.1 µM 0.878477857725051 0.201720464147292 no 690 0.189842224373433 907 6438352 A 5-HT1B full agonist. SGTC_2784 7567673 72.73 µM 0.876223467981019 0.202320694262225 no 691 0.190454280456343 961 3471247 SGTC_658 3253-0951 102 µM 0.874550719371461 0.202766752302876 no 692 0.190909205917589 1000 1184878 SGTC_2506 ethyl hematommate 54.16 µM 0.874102514746666 0.202886371063231 no 693 0.19103121406543 862 3940691 An allergen. SGTC_2458 5808907 16.39 µM 0.873401199323564 0.203073625668132 no 694 0.191222218769345 1014 2731747 SGTC_518 1021-0119 62.6 µM 0.873133681888678 0.203145081294816 no 695 0.19129510853177 865 1097762 SGTC_2678 equilin 100 µM 0.870531751144148 0.203840856348783 no 696 0.192004937675754 974 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2520 obtusaquinone 4.71 µM 0.868222848026766 0.204459461526393 no 697 0.192636174316898 960 5967872 SGTC_869 0564-0080 44.1 µM 0.865694171763357 0.205138229027211 no 698 0.193328948505857 906 6843321 SGTC_54 0159-0055 9 µM 0.864273436915902 0.205520180869156 no 699 0.19371884935338 950 3319099 SGTC_1350 1495-0454 146 µM 0.861599952780259 0.206240066973687 no 700 0.194453848502489 994 1069057 SGTC_967 1306-0166 352 µM 0.861489468160791 0.206269849170159 no 701 0.194484259616788 960 4437607 SGTC_2330 7979373 200 µM 0.861121633414154 0.206369020948398 no 702 0.194585527733319 924 1863007 SGTC_3160 9100216 49.47 µM 0.860263037057514 0.20660061668603 no 703 0.19482203163923 968 17191039 SGTC_2242 6630449 61.2675 µM 0.858757615269099 0.207007056938878 no 704 0.195237128062195 862 691249 YDR170C SEC7 SGTC_2885 9057732 51.95 µM 0.858675615056018 0.207029209288077 no 705 0.195259753757028 974 6471414 SGTC_1496 4469-0713 57.4 µM 0.858609283625112 0.20704712974353 no 706 0.195278057249639 942 746691 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.858530314123635 0.207068465764648 no 707 0.195299849450293 955 6312947 SGTC_1610 st001799 48.1 µM 0.858512167529863 0.207073368804615 no 708 0.195304857341844 887 621897 SGTC_2257 7960413 200 µM 0.85583956908297 0.207796229622303 no 709 0.196043262473215 997 2974689 YIL048W NEO1 SGTC_1979 st071809 45.3 µM 0.855304952760581 0.20794100660126 no 710 0.19619117319373 978 4976333 SGTC_816 0325-0417 81.3 µM 0.854314776145495 0.208209309010016 no 711 0.196465301105821 961 68101 SGTC_3096 9117468 49.47 µM 0.85335298482462 0.208470115489032 no 712 0.196731792729852 875 41316311 SGTC_1698 5-fluorocytosine 1.055 µM 0.851701094905185 0.208918503544767 no 713 0.197190006387165 998 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1749 st037932 54.2 µM 0.851666839658638 0.20892780777809 no 714 0.197199515194086 907 594497 SGTC_2949 9072542 2.23 µM 0.85124724750478 0.209041795039176 no 715 0.19731601097925 983 16457352 SGTC_207 4185-0010 4.486 µM 0.849461560579367 0.20952730782531 no 716 0.197812255393549 1048 3761753 SGTC_1927 st060202 13.8 µM 0.849448081826706 0.209530975101838 no 717 0.197816004019234 974 688887 SGTC_2532 xanthone 78.9 µM 0.849129147317253 0.209617761287197 no 718 0.197904716596284 884 7020 An insecticide. SGTC_419 nsc-638432 893 µM 0.848402091077098 0.209815681660463 no 719 0.198107039257593 968 368090 SGTC_1841 st054148 70 µM 0.847878010362545 0.209958415831635 no 720 0.198252956028755 902 675442 SGTC_2293 7624732 200 µM 0.845318561624678 0.210656304899124 no 721 0.198966500125239 970 894453 SGTC_3163 9099914 49.47 µM 0.844144975378859 0.210976763145609 no 722 0.199294198985306 978 16268368 SGTC_1018 4259-0013 28.1 µM 0.843313207653066 0.211204057738393 no 723 0.199526649019367 965 6801262 SGTC_3297 9117502 71.43 µM 0.842136758057582 0.211525787350672 no 724 0.199855704087203 989 7453720 SGTC_440 fluspirilene 35.1 µM 0.840191068296087 0.212058514228235 no 725 0.200400632744796 979 3396 An atypical antipsychotic. SGTC_2673 kobusone 100 µM 0.839437385579545 0.212265082034727 no 726 0.200611955998884 1022 6710676 An epoxy ketone and protein crosslinker. SGTC_2771 fluoxetine 41.05 µM 0.838959165509968 0.212396212571568 no 727 0.200746112309101 957 3386 A selective serotonin reuptake inhibitor. SGTC_1285 0929-0069 65.5 µM 0.838927824732976 0.212404808034968 no 728 0.200754906297941 977 1206237 SGTC_3331 9141060 1.957 µM 0.837836596359929 0.212704213020823 no 729 0.201061241022438 950 4906567 YPR165W RHO1 SGTC_1761 st044296 37 µM 0.833855261999051 0.213798676264772 no 730 0.202181275074817 1029 1826700 SGTC_1368 1852-0141 284 µM 0.831676515890251 0.214398996360881 no 731 0.202795779852651 939 2838987 SGTC_2487 5918373 44.05 µM 0.830472526396094 0.214731157298865 no 732 0.203135837419763 1052 2876279 SGTC_1633 st005664 67.9 µM 0.830257584429699 0.214790487700247 no 733 0.203196581915412 1030 2063822 SGTC_497 capsazepine 133 µM 0.828955847806889 0.215150009329651 no 734 0.203564695781398 1009 2733484 A calcium channel blocker. SGTC_2382 9035899 200 µM 0.82868844356214 0.215223905905839 no 735 0.203640363371291 998 6462679 SGTC_755 1995-0008 37.3 µM 0.827389429604176 0.215583095096477 no 736 0.204008184944882 1043 689533 SGTC_2879 9041815 71.43 µM 0.827265503253925 0.215617380015026 no 737 0.204043295912092 940 4942971 SGTC_3248 9135562 49.47 µM 0.826070028544545 0.215948277103534 no 738 0.204382184119786 1007 17650701 SGTC_636 0kpi-0074 126 µM 0.824783944357007 0.216304582413163 no 739 0.204747131783844 957 616434 SGTC_997 3996-0078 137 µM 0.824680508352691 0.216333253789978 no 740 0.204776500292018 1033 735687 SGTC_523 1934-0222 13.7 µM 0.824493297967064 0.216385152141299 no 741 0.204829661168811 976 1361595 SGTC_2966 9084041 48.03 µM 0.821743570863955 0.217148259654754 no 742 0.205611427852183 958 17741380 SGTC_1709 st033179 39.1045 µM 0.819686834786783 0.217720062464244 no 743 0.206197328518543 1036 573381 SGTC_2749 bexarotene 57.39 µM 0.817901906262303 0.218217002092914 no 744 0.206706600879408 977 82146 An retinoic acid receptor inhibitor. SGTC_3102 9121669 49.47 µM 0.813456907903823 0.219457364822412 no 745 0.207978071555778 1024 41905072 SGTC_3237 9133362 49.47 µM 0.813390168913367 0.219476018938139 no 746 0.207997197043611 999 43845137 SGTC_1171 0368-0077 21.4 µM 0.812869713485391 0.219621521905378 no 747 0.208146380315627 970 3239779 SGTC_2691 st077356 60.2 µM 0.812711243675766 0.219665836078579 no 748 0.208191816617444 1042 2839272 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.812309717992645 0.219778140881579 no 749 0.208306967849185 959 521171 SGTC_2080 5212524 12.4 µM 0.812209425167258 0.219806197446319 no 750 0.208335736112799 1009 260183 SGTC_695 3505-6186 243 µM 0.811917897392848 0.219887762987296 no 751 0.208419372029451 1018 1819379 SGTC_2675 theaflavin digallate 100 µM 0.810171781556444 0.220376666112568 no 752 0.208920726629662 1031 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3034 9090421 49.47 µM 0.809754961897517 0.220493465453649 no 753 0.209040511188738 987 17173761 SGTC_312 4092-0653 6.84 µM 0.809467799306211 0.220573953505129 no 754 0.209123058759907 1073 1148278 SGTC_1897 st060201 15 µM 0.808962232856425 0.220715698301734 no 755 0.209268435193974 979 611878 SGTC_1304 1165-0502 251 µM 0.80754615642406 0.22111299881054 no 756 0.209675946740253 1029 767425 SGTC_3243 9134147 49.47 µM 0.806603505745425 0.221377699658398 no 757 0.209947476661419 1093 24282180 SGTC_2661 dactinomycin 12.96 µM 0.806113058287379 0.221515491296421 no 758 0.210088831424112 1057 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3104 9120930 49.47 µM 0.804839311816663 0.22187358037992 no 759 0.210456206493811 970 17014836 SGTC_2151 5563267 85.4165 µM 0.801974996191782 0.222680033545494 no 760 0.211283710992958 1032 5310824 SGTC_819 1013-0258 27.7 µM 0.80168226922452 0.222762545339941 no 761 0.211368387416435 1034 5753198 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.801215062093017 0.222894274450747 no 762 0.211503576467549 1040 5355888 SGTC_1574 spiramycin 23.7 µM 0.799392470109651 0.223408578514064 no 763 0.21203143762598 1077 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3204 9114183 49.47 µM 0.799221789197794 0.223456776278723 no 764 0.212080909847142 992 17027248 SGTC_2711 st079103 59.1 µM 0.797948529361942 0.223816512630043 no 765 0.212450179817953 1034 54693780 SGTC_1550 gossypolone 36.6 µM 0.797228813023411 0.224020000892907 no 766 0.212659077542269 1076 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2204 7233102 200 µM 0.797114331479069 0.224052378401261 no 767 0.212692316872956 992 2172480 SGTC_68 0986-0284 82.829 µM 0.796549650370915 0.224212119600622 no 768 0.212856314508864 880 423278 YIL048W NEO1 SGTC_2149 5554786 194.827 µM 0.796422731943799 0.224248032130155 no 769 0.212893184977185 1073 745063 YPR165W RHO1 SGTC_441 propafenone 146 µM 0.794969979557621 0.224659331988742 no 770 0.213315482595756 1056 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1827 berberine 7.24 µM 0.791161717069249 0.225739546909122 no 771 0.214424814080641 983 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_277 nystatin 15.5 µM 0.79088751857921 0.225817436627633 no 772 0.214504816250132 1091 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3002 9075603 71.4286 µM 0.789705291940784 0.22615343778088 no 773 0.214849950048054 1082 20105405 SGTC_1242 0402-0103 60.1 µM 0.788256685058799 0.226565531889775 no 774 0.215273289157992 1013 432868 SGTC_262 fenpropimorph 62.5 µM 0.786814115091387 0.226976329563057 no 775 0.215695344704494 982 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1388 3346-4487 254 µM 0.785982372217128 0.227213374045065 no 776 0.215938907234107 1099 3345614 SGTC_14 0354-0009 295 µM 0.785421874608093 0.227373193015943 no 777 0.216103129784934 1080 1713507 SGTC_2444 5485484 36.41 µM 0.784413191118279 0.227660966133023 no 778 0.216398850348954 1091 6790631 SGTC_37 0566-0070 1.56 µM 0.784342432531974 0.227681160950659 no 779 0.216419603769552 1093 1626686 SGTC_1363 1636-0063 10.4 µM 0.783170537998398 0.228015771522865 no 780 0.216763486709392 1104 6072185 SGTC_32 0928-0142 34.1 µM 0.78290277103559 0.228092265717146 no 781 0.216842105074503 1054 2244242 SGTC_1088 bifonazole 369 nM 0.782633962698444 0.228169071918862 no 782 0.216921045774045 1017 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2993 9054257 71.4286 µM 0.782299658096906 0.228264612554127 no 783 0.217019243874185 1119 6470217 YGL055W OLE1 SGTC_1334 1486-0610 236 µM 0.781974932217838 0.22835743722052 no 784 0.217114652927102 1064 3742339 SGTC_1084 voriconazole 435 nM 0.780670275463984 0.228730594229935 no 785 0.21749822371777 1099 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1669 st015249 58.4 µM 0.779926052413964 0.228943609637908 no 786 0.217717201359876 1167 722793 SGTC_2156 5649887 115 µM 0.77907755545235 0.229186606619709 no 787 0.217967015306585 1124 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_289 k017-0060 526 µM 0.778567481496834 0.229332753838582 no 788 0.218117270468887 1083 5512909 SGTC_1571 st070080 73.4 µM 0.778344835240149 0.229396563181629 no 789 0.218182875257459 1070 4315245 SGTC_3301 9125354 19.7965 µM 0.777167628336554 0.229734110357514 no 790 0.218529939169207 1009 41905162 SGTC_710 3448-4187 58 µM 0.776946390642372 0.229797578124767 no 791 0.218595199889659 1104 3946412 SGTC_973 1325-0077 65.9 µM 0.776481874553305 0.229930868547697 no 792 0.218732259403128 1117 2835149 SGTC_654 1124-0271 80.9 µM 0.772783660690681 0.23099359375522 no 793 0.219825212438595 1068 5403748 SGTC_341 1486-1430 230 µM 0.771726039233895 0.231298017138956 no 794 0.220138352455359 1080 2054753 YPL210C SRP72 SGTC_1042 0350-0096 82 µM 0.771688788018207 0.231308743523472 no 795 0.220149386438433 1043 3122515 SGTC_2315 7733312 200 µM 0.771381828632515 0.231397142191815 no 796 0.220240321309151 1046 726316 SGTC_2504 purpurogallin 52.29 µM 0.769815804273495 0.23184842156479 no 797 0.220704581703109 1021 5281571 An antioxidant. SGTC_2740 felodipine 17.08 µM 0.769216960487814 0.232021119150451 no 798 0.22088226176032 1039 3333 L-type calcium channel blocker SGTC_27 0485-0001 32.618 µM 0.768948724950417 0.232098497483995 no 799 0.220961875184292 1025 2054479 SGTC_3090 9117696 49.47 µM 0.768571494724368 0.232207341991106 no 800 0.221073866473279 1071 7923821 SGTC_2413 inermin 26.06 µM 0.767850531498232 0.232415444849999 no 801 0.221287994803581 1093 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1751 st044839 27.194 µM 0.767009971648516 0.232658199661946 no 802 0.221537793409471 1100 5291326 SGTC_473 2-arachidonoylglycerol 10 µM 0.765703612361841 0.233035757551148 no 803 0.221926338586089 1012 5282280 An endocannabinoid. SGTC_1498 4478-3555 97.6 µM 0.765350526938308 0.233137863036383 no 804 0.22203142212454 1068 3437919 SGTC_3280 9140961 49.47 µM 0.764991104865572 0.233241826462725 no 805 0.222138420715287 1062 4901226 SGTC_854 0422-0053 192 µM 0.764494668200941 0.233385463889487 no 806 0.222286256416909 1106 3596728 SGTC_1172 0370-0043 85 µM 0.76341383256398 0.23369835915371 no 807 0.222608316511422 1103 376585 SGTC_58 0957-0393 9 µM 0.762853269323128 0.233860730298165 no 808 0.222775454060159 1100 6997992 SGTC_2358 9037157 4 µM 0.762589995157171 0.233937011109106 no 809 0.222853976564779 1082 2388925 SGTC_3315 9136395 68.55 µM 0.762578778676502 0.233940261267862 no 810 0.22285732227227 1139 16876844 SGTC_823 0417-1665 178 µM 0.761622675443088 0.234217399754145 no 811 0.223142618656252 1096 3429856 SGTC_1641 st009299 47.1 µM 0.761129102800073 0.23436053906494 no 812 0.223289979586895 1058 4046054 SGTC_2603 homopterocarpin 100 µM 0.7597001534057 0.234775216618098 no 813 0.22371691852102 1087 101795 A weak amylase inhibitor. SGTC_291 SEC14.278 35.5 µM 0.758300363912734 0.23518182502017 no 814 0.224135594741615 1120 1068044 SGTC_865 0488-0499 301 µM 0.757271798057586 0.235480848720375 no 815 0.224443521609574 1135 9634651 SGTC_2598 perillyl alcohol 100 µM 0.756954118533939 0.235573246600054 no 816 0.224538675410207 1096 10819 An apoptosis inducer. SGTC_428 3448-4153 16.5 µM 0.756848088512981 0.235604090146634 no 817 0.224570439426849 1069 3834874 SGTC_2932 9016711 44.54 µM 0.755000340198156 0.236141947425112 no 818 0.225124389048271 1118 7117328 SGTC_2047 4141938 200 µM 0.75253837277194 0.236859646275156 no 819 0.225863681300316 1064 3807862 SGTC_84 0443-0269 128.823 µM 0.750673633993063 0.237404041613265 no 820 0.226424547216808 1087 6150058 SGTC_1642 st009582 77.7 µM 0.749125367113823 0.237856567026719 no 821 0.22689082345043 1101 6739311 SGTC_234 nsc-17383 10.7 µM 0.748922085064635 0.237916017147708 no 822 0.226952084094466 1150 408974 SGTC_1635 st007035 42.4 µM 0.748727054922569 0.237973061643776 no 823 0.227010866728345 1142 3716403 SGTC_3106 9121286 49.47 µM 0.748537243189673 0.238028587002975 no 824 0.227068084761878 1128 15943471 SGTC_245 methotrexate 289.6 µM 0.74813073052203 0.238147527468393 no 825 0.227190653828105 1109 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1254 0550-0035 264 µM 0.747515690402291 0.238327542322963 no 826 0.227376167611597 1130 15121435 SGTC_1570 verbenone 133 µM 0.74646022474446 0.238636638053289 no 827 0.227694725200726 1121 29025 A natural terpanoid with antifungal properties. SGTC_1510 1123-0200 71.5 µM 0.746429044831351 0.238645772502955 no 828 0.227704139650766 1147 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2466 5983409 37.09 µM 0.745396980669307 0.238948233394661 no 829 0.228015884309874 1064 2879657 SGTC_1433 4060-0023 7.6 µM 0.743105737539187 0.23962046294966 no 830 0.228708833118539 1134 3840627 SGTC_2102 5377816 72.7585 µM 0.742163601988927 0.239897176011494 no 831 0.228994109218843 1155 1379702 SGTC_2617 dihydrotanshinone i 20.83 µM 0.742107268670737 0.239913727096911 no 832 0.229011173118862 1160 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3085 9117376 49.47 µM 0.741448094638439 0.240107442872488 no 833 0.229210896233238 1111 16480349 SGTC_2417 cerulenin 830 nM 0.74092876237568 0.240260122464766 no 834 0.229368317461443 1121 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1327 1436-0082 2.18 µM 0.739817034504058 0.240587139459236 no 835 0.229705510693274 1078 15992205 SGTC_2531 methyl deoxycholate 70.07 µM 0.738257634864713 0.241046248053997 no 836 0.230178952738885 1114 16667744 Haematoxylin. SGTC_1060 3448-7350 82 µM 0.738097654484555 0.241093375396256 no 837 0.230227554488592 1085 570178 SGTC_3059 1327-0034 3 µM 0.737880287381774 0.241157415861212 no 838 0.23029359941723 1103 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_389 tpck 16.7 µM 0.736263272365319 0.241634109241031 no 839 0.230785246505498 1108 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3148 9097893 49.47 µM 0.73539106672356 0.2418914462669 no 840 0.231050680410511 1098 17174100 SGTC_2133 5320837 200 µM 0.734859281949986 0.242048417878003 no 841 0.231212599343598 1093 2841355 SGTC_31 0508-1974 57.237 µM 0.734727208746695 0.242087411654318 no 842 0.231252823078789 1112 6810525 SGTC_615 k087-0205 167 µM 0.734716590433493 0.242090546791933 no 843 0.23125605712323 1125 9642773 SGTC_108 0509-0257 621.132 µM 0.733218809660184 0.242532998438713 no 844 0.231712492413645 1131 536624 SGTC_2728 chlorpromazine 9.18 µM 0.732759497053066 0.242668769285516 no 845 0.23185256432633 1131 2726 A thorazine and dopamine antagonist. SGTC_2773 thioridazine 9.09 µM 0.732136105610468 0.242853106940395 no 846 0.232042749122082 1175 5452 An antipsychotic. SGTC_632 0781-2353 4.65 µM 0.730965798484009 0.243199372822871 no 847 0.232400021886895 1171 6811515 YHR007C ERG11 SGTC_1114 scopoletin 1.73284 µM 0.729478888205216 0.24363969871757 no 848 0.232854388639031 1161 5280460 A coumarin with genotoxic properties. SGTC_527 4476-4215 268 µM 0.725529802532664 0.244811247483203 no 849 0.234063534187001 1100 4418754 SGTC_1243 0416-0003 5.65 µM 0.725429585113574 0.244841017713939 no 850 0.234094264301137 1143 2141977 SGTC_1747 st037496 66.6 µM 0.722399288083053 0.245742106493849 no 851 0.235024512240897 1182 723305 SGTC_2072 5231554 129 µM 0.721357500985129 0.246052302969585 no 852 0.235344793683606 1222 789545 SGTC_2268 7933382 153.85 µM 0.721271631190291 0.246077880427938 no 853 0.23537120377668 1220 935025 YOR257W CDC31 SGTC_1135 dihydrocapsaicin 536.708 nM 0.719914740616937 0.246482237558561 no 854 0.235788745793394 1115 107982 A Capsaicinoid. SGTC_3336 9143619 71.43 µM 0.719160439373524 0.246707175280334 no 855 0.236021035679079 1187 45595730 SGTC_1293 1000-1278 195 µM 0.718718312912413 0.246839071455037 no 856 0.236157248769635 1176 678847 SGTC_1014 4130-3005 69.3 µM 0.715124535944744 0.247912574141912 no 857 0.237266047018814 1197 743608 SGTC_1652 st011932 78 µM 0.714888711676452 0.247983104589265 no 858 0.237338906387836 1141 1551076 SGTC_1323 1348-1351 11.2 µM 0.713457264141918 0.248411452327944 no 859 0.237781424488828 1111 6989654 SGTC_1119 parthenolide 318.541 nM 0.712348846181975 0.248743407092238 no 860 0.238124391777712 1236 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3061 glucosamine 200 µM 0.712162569566541 0.248799217354679 no 861 0.238182056184597 1128 91431 and experimental redox chemotherapeutic SGTC_1268 0828-0275 2.46 µM 0.712045400586283 0.248834325721411 no 862 0.238218331322207 1204 745337 SGTC_871 0574-0004 149 µM 0.711192930359596 0.249089838211868 no 863 0.238482344447084 1128 9551173 SGTC_2446 5162541 200 µM 0.710859939983918 0.24918968393335 no 864 0.238585516267364 1122 1549321 SGTC_1896 st058441 89 µM 0.709722916114624 0.249530775977327 no 865 0.238937989248649 1128 688759 SGTC_1287 0971-0001 34.6 µM 0.709457545008658 0.24961041947097 no 866 0.239020294224345 1171 4665869 SGTC_405 ebelactone b 50 µM 0.707846758618237 0.250094140208199 no 867 0.239520212810177 1160 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2173 5763948 167 µM 0.706123641993427 0.250612143822608 no 868 0.240055625209331 1203 2867177 SGTC_3334 9142812 21.919 µM 0.705994066517334 0.250651119787715 no 869 0.240095913684493 1172 45283678 SGTC_548 1436-0017 110 µM 0.705402117465068 0.250829217347364 no 870 0.240280013324307 1230 9677137 SGTC_1378 2093-0007 380 nM 0.703739874007932 0.251329688471654 no 871 0.240797391823771 1183 3618014 SGTC_3088 9117578 49.47 µM 0.702004233880644 0.251852820839289 no 872 0.2413382615321 1240 678341 SGTC_2750 bromebric acid 70.15 µM 0.701929399956775 0.251875389152585 no 873 0.241361596524891 1198 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2327 6189656 200 µM 0.701254552716129 0.252078956877898 no 874 0.241572085265235 1207 5349088 SGTC_1454 4239-0054 42.6 µM 0.698689513611228 0.252853492354403 no 875 0.242373044382727 1253 1340767 SGTC_372 0155-0182 15.9 µM 0.69763346249887 0.25317273968265 no 876 0.242703224586093 1188 771486 SGTC_2518 prenyletin 46.28 µM 0.697233739904452 0.253293632268616 no 877 0.24282826355524 1118 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2990 9074105 71.4286 µM 0.696961404027608 0.253376015240785 no 878 0.242913474092132 1161 6502001 SGTC_2020 4017018 200 µM 0.694710082590929 0.254057590378532 no 879 0.243618504049777 1215 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1226 3909-7979 35.4 µM 0.691127871678283 0.255144064485532 no 880 0.244742593148389 1210 6615510 SGTC_570 0987-0065 62.6 µM 0.690728484046247 0.255265347972173 no 881 0.244868092807708 1090 3104428 SGTC_1992 st073643 23.3 µM 0.687993076778579 0.256096828441374 no 882 0.245728570571029 1210 3161292 SGTC_2323 6148992 148.28 µM 0.686425354714145 0.256574004182181 no 883 0.246222460210338 1177 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2340 7987427 183.45 µM 0.685303627764783 0.256915714055263 no 884 0.246576171524841 1177 2239331 SGTC_1675 st018485 24.5 µM 0.684930224503064 0.257029515799513 no 885 0.246693976184809 1207 3323024 SGTC_91 0417-1751 58.384 µM 0.684332912637369 0.257211612452483 no 886 0.246882484219748 1306 6795624 SGTC_1922 5578187 25 µM 0.681184482201464 0.258172551098163 no 887 0.247877382857316 1236 1350412 SGTC_369 0957-0393 4.5 µM 0.680523997471649 0.258374374863042 no 888 0.248086366129979 1204 6997992 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.679396276303841 0.258719160525839 no 889 0.2484434043212 1304 6728940 SGTC_1803 st050068 52.4 µM 0.679107028150981 0.258807632639538 no 890 0.248535024820808 1309 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2712 st079126 47.7 µM 0.679026393416307 0.258832299115121 no 891 0.248560569401183 1196 3152970 SGTC_2098 5376439 882.5 nM 0.67896870942856 0.258849945615271 no 892 0.248578844186452 1264 2844116 SGTC_2254 7938975 95.19 µM 0.678923592883358 0.258863747957616 no 893 0.248593137996272 1263 2969277 SGTC_3005 9076496 71.4286 µM 0.677639493048529 0.259256747591927 no 894 0.249000149617388 1232 21368410 SGTC_1212 0520-0165 585 µM 0.677171859832681 0.259399943612136 no 895 0.249148459887415 1352 5403258 SGTC_576 1073-0113 22.7 µM 0.675159721798586 0.260016555033031 no 896 0.249787146832908 1370 5439563 SGTC_2215 7188065 200 µM 0.6734413068188 0.260543753966991 no 897 0.250333288513018 1242 940217 SGTC_1479 0549-0158 134 µM 0.673396415945552 0.260557533577855 no 898 0.250347564080253 1271 5440202 SGTC_1050 3232-1156 69.3 µM 0.671762735284629 0.261059260022653 no 899 0.250867377836053 1202 700529 SGTC_1704 st028805 70.8 µM 0.66988309014789 0.261637139478023 no 900 0.251466160066402 1230 2876101 SGTC_2755 lomerizine 42.69 µM 0.667601006704201 0.262339626173214 no 901 0.252194157468006 1254 3949 A calcium channel blocker. SGTC_718 1130-0073 349 µM 0.665035089124286 0.263130636709455 no 902 0.253014025071746 1307 6740020 SGTC_820 1582-0060 59.9 µM 0.66424275365944 0.263375140650813 no 903 0.253267476924021 1232 3848840 SGTC_1111 tnp00062 510.699 nM 0.663637630179751 0.263561951614791 no 904 0.253461133372469 1280 676306 SGTC_376 3970-0862 59.1 µM 0.663129546581408 0.263718857071664 no 905 0.253623794418877 1226 3135186 SGTC_479 n-linoleoylglycine 10 µM 0.661793836692247 0.264131575719347 no 906 0.254051678303139 1244 6433346 An anti-infammatory. SGTC_1002 4049-0206 172 µM 0.661182694751315 0.264320521045059 no 907 0.254247578893124 1271 4662749 SGTC_827 3253-0474 693 µM 0.66116690179451 0.264325404628566 no 908 0.254252642350261 1252 5402065 SGTC_2543 pimpinellin 60.67 µM 0.660557770321569 0.264513798604876 no 909 0.254447979311221 1197 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_335 4077-0256 27.6 µM 0.660368037446162 0.264572493699481 no 910 0.254508839120231 1266 3121989 SGTC_2915 7971052 15.16 µM 0.659849124508225 0.264733056615131 no 911 0.254675327565725 1129 5741558 SGTC_2167 5876490 200 µM 0.65957722833372 0.264817206966105 no 912 0.254762585719483 1316 686534 SGTC_3246 9135460 32.98 µM 0.658772442921472 0.265066363233375 no 913 0.255020952806822 1190 41446951 SGTC_3144 9087057 49.47 µM 0.65819449037697 0.265245366975848 no 914 0.255206582349826 1198 17249618 SGTC_278 4092-0821 23.9 µM 0.653393148315026 0.266734809930853 no 915 0.256751427420867 1257 877900 SGTC_1861 st057647 17.4 µM 0.65057740340939 0.267610255347841 no 916 0.257659660465349 1329 688668 SGTC_1027 k015-0025 8.67 µM 0.650221263959552 0.267721086033543 no 917 0.257774653801974 1244 3598955 SGTC_1911 st060208 74.3 µM 0.649528270322651 0.267936812099249 no 918 0.25799848980759 1292 688783 SGTC_3069 9117009 49.47 µM 0.646082180185916 0.269010864123835 no 919 0.259113067597427 1168 41904981 SGTC_1998 st075797 76.8 µM 0.644347111906922 0.269552454211758 no 920 0.25967518597802 1272 24208315 SGTC_1737 st035557 69.7 µM 0.640925225552271 0.27062217231866 no 921 0.260785632850827 1233 5716916 SGTC_1037 k284-1091 78.7 µM 0.640263052028488 0.270829419390775 no 922 0.261000798603293 1258 3334711 SGTC_651 3253-0966 34.4 µM 0.638499315918736 0.271381819751628 no 923 0.261574349608131 1302 781462 SGTC_2146 5545642 200 µM 0.637825459543632 0.271593019008577 no 924 0.261793652278889 1300 825326 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.635584264608805 0.272296039882702 no 925 0.262523714129425 1249 6708514 SGTC_2233 sulbentine 40.3845 µM 0.634188476763323 0.272734328822349 no 926 0.262978913438573 1283 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2893 9048488 25.97 µM 0.633996745300276 0.272794561421889 no 927 0.263041473089053 1243 6467338 SGTC_2996 9066192 71.4286 µM 0.633935349508011 0.272813850356198 no 928 0.263061507398877 1265 6472854 SGTC_3356 9151811 4.48 µM 0.63274648774542 0.27318749262149 no 929 0.263449603385901 1272 1859254 YPR165W RHO1 SGTC_2742 clothiapine 36.27 µM 0.631153926881188 0.273688408736467 no 930 0.263969941842059 1260 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_142 0335-0849 62.6745 µM 0.62977618559409 0.274122122832566 no 931 0.26442051435013 1333 3889043 YPR107C YTH1 SGTC_1769 st044406 64.4 µM 0.628556866955669 0.274506248359893 no 932 0.264819603034622 1299 670903 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.626559618396686 0.275136020701761 no 933 0.265473972735715 1278 6857784 SGTC_1228 0124-0032 52.5 µM 0.62598195641395 0.275318301617067 no 934 0.2656633881953 1369 X1228 SGTC_3256 9138902 49.47 µM 0.625183774782887 0.2755702651417 no 935 0.265925224801609 1325 17228773 SGTC_273 hydroxyurea 18.1 mM 0.625146128024568 0.275582151965752 no 936 0.265937577724527 1336 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1596 piperlongumine 63 µM 0.62457439438536 0.275762705722458 no 937 0.266125214772827 1342 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_650 1328-0195 38 µM 0.623842966857434 0.275993775614928 no 938 0.26636535940047 1295 2780821 SGTC_2774 tamoxifen 10.92 µM 0.623547758913385 0.276087063548013 no 939 0.266462314067091 1324 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2390 9097792 176.6 µM 0.62276130239406 0.276335665260628 no 940 0.266720695807073 1270 4497149 SGTC_1339 1486-1321 22.7 µM 0.620945407029196 0.276910095428326 no 941 0.267317771876161 1310 3469382 SGTC_296 1222-0039 74.9 µM 0.620463274123049 0.277062708822652 no 942 0.267476412963223 1268 5984176 SGTC_519 k048-0011 62.8 µM 0.620398997712271 0.277083057859713 no 943 0.267497566069666 1324 6836379 SGTC_907 3448-6986 75.5 µM 0.619483958942897 0.277372825979387 no 944 0.267798793078395 1369 590582 SGTC_1371 2421-0008 32.7 µM 0.619225595337371 0.277454669586038 no 945 0.267883876245239 1315 2827552 SGTC_2946 9065502 71.43 µM 0.617024798303758 0.278152309262164 no 946 0.268609184558669 1173 16489101 SGTC_1631 benzylvanillin 81.9 µM 0.616072846179609 0.278454337307548 no 947 0.268923221291327 1333 75506 SGTC_1573 oleylamine 1.06 µM 0.615927160049706 0.278500573576459 no 948 0.268971297526161 1323 5356789 An amine of the fatty acid oleic acid. SGTC_1726 st035556 14.5795 µM 0.614051790353263 0.279096091601249 no 949 0.269590552090304 1416 5919439 SGTC_1637 st007924 17.4 µM 0.613279471895822 0.279341518880683 no 950 0.269845782236569 1296 683336 SGTC_1179 1021-1431 9.29 µM 0.613065661819646 0.27940948195195 no 951 0.269916461999526 1333 2840958 SGTC_64 000l-0018 272.079 µM 0.611141479364753 0.280021476314577 no 952 0.27055296073895 1309 6811119 SGTC_2918 7977171 22.06 µM 0.611091080744426 0.280037514537689 no 953 0.270569642128722 1270 2236483 SGTC_2337 9009472 200 µM 0.610854278253401 0.280112877545045 no 954 0.270648028029978 1395 5742383 SGTC_379 3970-0972 5.9 µM 0.610677452052038 0.280169159351827 no 955 0.270706568091485 1339 2898042 YBL034C STU1 SGTC_3045 9092950 49.47 µM 0.610023978797573 0.280377200124805 no 956 0.270922961711322 1403 44120432 SGTC_2212 7123476 200 µM 0.609283425487619 0.280613054220432 no 957 0.271168295640094 1298 1085715 SGTC_3349 9149703 23.001 µM 0.608584323051216 0.280835794938989 no 958 0.271399999131723 1301 4910494 SGTC_53 0973-0023 39.979 µM 0.607380737279033 0.281219469016331 no 959 0.271799134478316 1316 674768 SGTC_1681 tripelennamine 100 µM 0.607014682129986 0.281336208733257 no 960 0.271920584269544 1316 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_630 4356-0227 183 µM 0.606378347111638 0.281539199850265 no 961 0.272131771757779 1353 779312 SGTC_223 busulfan 5 mM 0.606125338626252 0.281619929279875 no 962 0.272215763110005 1349 2478 A DNA alkylator. SGTC_1217 1183-1422 255 µM 0.605968785502284 0.2816698875203 no 963 0.272267740579622 1371 2849664 SGTC_112 phenothiazine 287.218 µM 0.605764839211244 0.281734975976322 no 964 0.272335460531625 1335 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1395 3486-0190 4.35 µM 0.604563306239405 0.282118586430863 no 965 0.272734596905735 1390 6748079 SGTC_729 4092-0585 94.1 µM 0.603395438895974 0.282491689378538 no 966 0.273122827885263 1297 2169061 SGTC_1077 5-fluorocytosine 377 nM 0.603070676874065 0.282595484464215 no 967 0.273230836293352 1335 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3187 9109394 49.47 µM 0.602534186246444 0.282766988902626 no 968 0.273409307122522 1269 17098090 SGTC_2342 7990637 118.86 µM 0.602082767883268 0.282911336307865 no 969 0.273559522220684 1381 2033102 YER133W GLC7 SGTC_1795 st049545 62.3 µM 0.602037842084272 0.282925703903118 no 970 0.273574474075782 1315 5291882 SGTC_522 1273-0010 11.6 µM 0.601691085716304 0.28303661088258 no 971 0.273689892439324 1387 5705015 SGTC_1456 k015-0012 13 µM 0.600719420260505 0.283347500663805 no 972 0.274013440972352 1394 2989616 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.60064430504544 0.283371541012405 no 973 0.274038460966027 1342 229346 A bile salt which induces apoptosis. SGTC_454 lyso-paf C-16 6.67 µM 0.599696852767302 0.283674853562853 no 974 0.274354143052144 1262 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1463 k081-0032 34.1 µM 0.598972370757014 0.283906890412133 no 975 0.27459565462563 1232 977755 SGTC_1299 1079-1439 3.74 µM 0.598946804589662 0.283915080394507 no 976 0.274604179216776 1303 323161 SGTC_1934 st074720 32.6 µM 0.596445501144553 0.284716905502146 no 977 0.275438825653986 1319 17250992 SGTC_3040 9091894 49.47 µM 0.595585369626948 0.284992881296169 no 978 0.275726126397039 1286 25236966 SGTC_2627 acetyl isogambogic acid 100 µM 0.595416707271514 0.28504701207791 no 979 0.275782480189622 1285 6857789 A caspase activator and apoptosis inducer. SGTC_1921 5740136 50 µM 0.594577729597562 0.285316347806243 no 980 0.276062885108869 1404 1774243 SGTC_2566 crystal violet carbinol 226 nM 0.590916606220251 0.286493089229689 no 981 0.277288149360079 1284 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1116 jasmonic acid  1.58368 µM 0.590576232491093 0.286602607476571 no 982 0.277402196858564 1401 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2862 9027634 71.43 µM 0.5902164839547 0.286718381318311 no 983 0.277522761109153 1306 5012562 SGTC_1185 1319-0113 81.3 µM 0.589924433973335 0.286812384795964 no 984 0.277620656047692 1388 4672763 SGTC_2056 5235370 200 µM 0.589663376000777 0.286896425094985 no 985 0.277708176765432 1336 5511916 SGTC_1711 st032263 62.8 µM 0.58846596290337 0.287282048109014 no 986 0.278109786815053 1374 3958979 SGTC_25 0118-0223 35.662 µM 0.587416998768387 0.287620065031034 no 987 0.278461840001641 1393 5333628 SGTC_2654 protoveratrine a 100 µM 0.586045077689012 0.288062434701727 no 988 0.278922611402832 1339 5702278 A heart drug and vasodilator. SGTC_67 0335-0847 266 µM 0.585262545367344 0.28831490239593 no 989 0.279185597582961 1573 4552207 YOR254C SEC63 SGTC_1203 3992-3522 103 µM 0.584992268810874 0.288402125712361 no 990 0.279276457608511 1594 5322312 SGTC_508 roscovitine 141 µM 0.58412794832071 0.288681141615946 no 991 0.279567116336748 1422 160355 A CDKinase inhibitor. SGTC_559 1550-0661 158 µM 0.583375948037385 0.288924002206861 no 992 0.279820122787 1406 5830875 SGTC_412 gemfibrozil 100 µM 0.583363147842808 0.288928136897477 no 993 0.279824430304811 1344 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_333 3486-0131 40.1 µM 0.583022361360246 0.289038227232309 no 994 0.279939123500467 1437 6744690 SGTC_169 k015-0017 16.025 µM 0.582518078284601 0.289201170979445 no 995 0.280108884007847 1434 1840002 SGTC_2445 5742597 35.57 µM 0.581940885651509 0.289387726217631 no 996 0.280303249805087 1331 1774255 SGTC_2496 diffractaic acid 79.83 µM 0.58155930772323 0.289511087588675 no 997 0.280431779500873 1465 94870 An apoptosis inducer which activates caspases. SGTC_3174 9107204 49.47 µM 0.581225136680314 0.289619142938093 no 998 0.280544364217183 1387 3938802 SGTC_1225 1216-0074 20.6 µM 0.580178422449425 0.289957724031213 no 999 0.280897151540156 1339 4241466 SGTC_3353 9151644 39.2805 µM 0.579127306548501 0.290297915589089 no 1000 0.281251638073027 1357 4909158 SGTC_301 4119-0100 24.5 µM 0.579117914398886 0.29030095618195 no 1001 0.28125480652826 1372 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2995 9067767 71.4286 µM 0.578743236532482 0.290422265694547 no 1002 0.281381218702363 1379 11673567 SGTC_2396 5342950 42.78 µM 0.576636623968078 0.291104765390774 no 1003 0.282092476559647 1384 1886677 SGTC_581 0958-0271 211 µM 0.57566563626581 0.291419597695298 no 1004 0.2824206033801 1363 4591145 SGTC_1434 4073-0095 163 µM 0.575165974601097 0.291581669488099 no 1005 0.282589526041287 1364 24133745 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.57432098917218 0.291855847148977 no 1006 0.282875304186915 1265 6708630 An antioxidant. SGTC_769 0302-0231 76 µM 0.572762098621289 0.292361984935899 no 1007 0.283402892415564 1387 571869 YER009W NTF2 SGTC_2170 morpholine 200 µM 0.57208846709798 0.292580824631007 no 1008 0.283631020982922 1454 121171 Reacts with secondary amines. SGTC_2121 5257820 149.641 µM 0.571540956056275 0.29275874817383 no 1009 0.283816503022409 1415 791256 SGTC_1651 st011928 86.1 µM 0.5703841221691 0.293134847247874 no 1010 0.284208598142459 1387 720198 SGTC_2438 5259590 200 µM 0.570157878389838 0.293208427708281 no 1011 0.284285311055019 1419 1201127 SGTC_2332 7982454 138.89 µM 0.569964036861641 0.293271476910067 no 1012 0.284351045145922 1390 2981748 SGTC_920 mycophenolic acid 780.421 nM 0.569830740483586 0.293314836746808 no 1013 0.284396251832313 1388 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2607 solasodine 47.35 µM 0.569407147835805 0.293452646466102 no 1014 0.284539933591468 1388 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2070 5230947 200 µM 0.569238955192176 0.293507373818884 no 1015 0.284596993806153 1431 2835538 SGTC_1895 st058434 18.3 µM 0.568134905283922 0.293866732324916 no 1016 0.284971683969241 1400 5393175 SGTC_722 3534-0461 190 µM 0.567710952043084 0.294004779423621 no 1017 0.285115626827529 1341 658262 SGTC_2783 7738165 71.43 µM 0.566447374396948 0.294416401658093 no 1018 0.28554484888914 1315 17201110 SGTC_1819 st053448 58.6 µM 0.565764458112652 0.29463897871721 no 1019 0.285776955264453 1398 2857616 SGTC_1307 1187-1599 12.2 µM 0.564535230910365 0.295039805689263 no 1020 0.28619496520383 1366 1538471 SGTC_723 4182-0001 115 µM 0.563410470472785 0.295406788002396 no 1021 0.286577704508315 1342 744821 YLR208W SEC13 SGTC_1257 0669-0121 16 µM 0.562879617564353 0.295580065466507 no 1022 0.28675843018131 1443 4307855 SGTC_1668 st014914 51.6 µM 0.562495521574279 0.295705468645963 no 1023 0.28688922702496 1392 2839556 SGTC_2919 7978188 46.38 µM 0.5623331594109 0.295758485484175 no 1024 0.28694452498049 1407 2980291 SGTC_2331 7980721 200 µM 0.561677720679706 0.295972553191165 no 1025 0.287167808248892 1424 2981221 SGTC_2882 9058044 58.44 µM 0.558679777226964 0.296952593539136 no 1026 0.288190141618837 1314 18076804 SGTC_1003 4049-0218 100 µM 0.557484915125969 0.297343612348642 no 1027 0.288598081386132 1457 295161 SGTC_602 3130-1533 38.1 µM 0.554638680574752 0.298275989230837 no 1028 0.289570913051766 1466 720941 SGTC_2350 9023895 38.85 µM 0.55129799026324 0.299372036116653 no 1029 0.290714707981556 1474 2997209 SGTC_2967 9089538 49.85 µM 0.550539145830397 0.299621259687235 no 1030 0.290974817458834 1487 728216 SGTC_2983 9022671 12.99 µM 0.549979715823978 0.299805050726355 no 1031 0.291166643160671 1533 6405161 SGTC_786 4544-0069 423 µM 0.549403208309636 0.299994505675359 no 1032 0.29136438641213 1472 748821 YLR208W SEC13 SGTC_1991 st073000 8.92 µM 0.548604467365719 0.30025708162947 no 1033 0.291638459690257 1458 4301969 YIL048W NEO1 SGTC_886 0866-0150 153 µM 0.547151150665192 0.300735107343072 no 1034 0.292137446649395 1514 271463 SGTC_2683 piperine 63.03 µM 0.546045472348381 0.301099017511127 no 1035 0.292517340115474 1389 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1624 st003710 6.25 µM 0.541270831460352 0.302672761107597 no 1036 0.294160461093938 1505 24207033 SGTC_934 2950-0684 338 µM 0.538218728833282 0.303680674887478 no 1037 0.295213025751351 1529 1121253 SGTC_2669 eugenol 100 µM 0.537929466215865 0.303776277454862 no 1038 0.295312872308934 1438 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1028 k015-0029 4.8 µM 0.535509611281458 0.304576575623642 no 1039 0.296148756632315 1430 4588309 SGTC_1545 lovastatin 49.4 µM 0.534530139218215 0.304900774573379 no 1040 0.296487401516936 1470 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1848 st056003 16.4 µM 0.533172198895151 0.305350497523289 no 1041 0.296957192199349 1458 146492 SGTC_1207 2099-0101 141 µM 0.533024329169283 0.305399486807885 no 1042 0.297008369507934 1455 5837381 SGTC_979 1426-2828 121 µM 0.53302188322744 0.305400297178455 no 1043 0.297009216075647 1507 747872 SGTC_2407 paclitaxel 400 µM 0.532308513760563 0.305636685926468 no 1044 0.297256168281005 1569 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2703 st077852 53.4 µM 0.530339415988693 0.3062896047986 no 1045 0.297938311412483 1451 6281836 SGTC_2248 tofa 1.1 µM 0.529919846905078 0.306428806306827 no 1046 0.298083752475831 1458 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1767 st044992 70.3 µM 0.52787527880159 0.307107537394132 no 1047 0.298792951980084 1380 9600693 SGTC_2140 5586273 200 µM 0.527760850369994 0.30714554353277 no 1048 0.298832666429546 1434 854421 SGTC_2015 5119600 184 µM 0.526929693111119 0.307421665387765 no 1049 0.299121206493359 1532 2828786 SGTC_2157 5649910 96.377 µM 0.524568680507371 0.30820662135725 no 1050 0.299941531876612 1403 2858091 SGTC_1590 st077108 57.8 µM 0.521362710107365 0.30927390205614 no 1051 0.30105706164189 1462 5489485 SGTC_2570 licareol 100 µM 0.520683246207928 0.309500305612294 no 1052 0.301293723670783 1428 443158 SGTC_3119 9125183 49.47 µM 0.520667888045114 0.309505423928061 no 1053 0.301299073994441 1381 22695334 SGTC_2285 7945142 200 µM 0.520144478954398 0.309679879178846 no 1054 0.301481439604603 1453 2970608 SGTC_3071 9117417 49.47 µM 0.518332656094319 0.310284101074197 no 1055 0.302113096111327 1467 45595590 YGL055W OLE1 SGTC_935 2996-0153 430 µM 0.516852928393248 0.310777953367529 no 1056 0.302629414503755 1478 23738523 SGTC_2912 7964298 10.93 µM 0.515309155941439 0.311293543882791 no 1057 0.303168500937147 1462 2975850 SGTC_621 3584-0052 32.1 µM 0.511950361068819 0.312416595934962 no 1058 0.304342875356913 1496 2273927 SGTC_549 1661-1316 519 µM 0.510910630804195 0.312764595925153 no 1059 0.304706818427167 1543 2857282 SGTC_2889 9059656 51.95 µM 0.508711316690777 0.313501260963231 no 1060 0.305477294443808 1532 3949838 SGTC_1502 4534-4282 27.7 µM 0.507462028214452 0.313920044627408 no 1061 0.305915336460581 1471 3278949 SGTC_910 3454-3003 490 µM 0.506885650165707 0.314113337649037 no 1062 0.306117527418071 1441 820824 SGTC_1130 3454-2858 15.9 µM 0.50608198961493 0.314382936815818 no 1063 0.306399546714707 1445 715628 YIL048W NEO1 SGTC_1870 st057514 26.5 µM 0.505548809232665 0.314561854285597 no 1064 0.30658671284954 1470 5393161 SGTC_2591 skatole 100 µM 0.504472254844233 0.314923242589914 no 1065 0.306964777211555 1477 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_741 4582-0002 126 µM 0.503858763095057 0.315129264820644 no 1066 0.30718031512794 1438 2912688 SGTC_661 1304-0007 33.6 µM 0.503510672368052 0.315246185906995 no 1067 0.30730263939815 1464 3117130 SGTC_2057 5236571 38.335 µM 0.502739193946301 0.31550538572404 no 1068 0.307573824820247 1557 54684039 YBR257W POP4 SGTC_828 2074-0507 139 µM 0.502668128312235 0.315529266786625 no 1069 0.307598810674995 1557 X828 SGTC_2112 5488546 200 µM 0.502091951312661 0.315722915097594 no 1070 0.307801420788402 1443 600757 SGTC_3262 9137218 49.47 µM 0.498015579808073 0.317094392574865 no 1071 0.309236530526662 1413 17650664 SGTC_2045 5106652 78.05 µM 0.496341561465906 0.317658338743015 no 1072 0.309826723951229 1530 673349 SGTC_125 0133-0007 11.75 µM 0.496235760662042 0.317693995335893 no 1073 0.309864041674415 1581 26541 SGTC_3064 1327-0027 10 µM 0.495324634850623 0.31800112951744 no 1074 0.310185492130279 1420 16000455 YPR107C YTH1 SGTC_855 0428-0020 25 µM 0.494382566288619 0.318318825961838 no 1075 0.310518011944926 1479 6812414 SGTC_166 k072-0058 166.424 µM 0.494143314497254 0.318399530813843 no 1076 0.310602484784336 1503 5846229 SGTC_1798 st045719 60.953 µM 0.489350105345199 0.320018196624942 no 1077 0.312296926785609 1440 3980186 SGTC_2837 9008476 45.46 µM 0.488676507126441 0.320245946371021 no 1078 0.31253536930302 1532 2992805 SGTC_3300 9124615 50.48 µM 0.488487024779626 0.320310024303395 no 1079 0.312602457039214 1569 24824903 SGTC_2389 9091542 195.52 µM 0.487863415883205 0.320520950213256 no 1080 0.312823294582929 1487 3626624 YOL127W RPL25 SGTC_2903 5923464 63.88 µM 0.487408735206337 0.320674775359378 no 1081 0.312984352229258 1509 2876576 SGTC_2674 ligustilide 100 µM 0.484066625880162 0.321806403813551 no 1082 0.314169292900044 1500 5319022 A signalling regulator. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.483884283818324 0.321868192002034 no 1083 0.314233997333927 1488 4620898 SGTC_3350 9150499 3.57 µM 0.479479332899899 0.32336234123548 no 1084 0.315798833732269 1471 4910996 YPR165W RHO1 SGTC_1792 st045773 43.6 µM 0.479063603902038 0.323503503274364 no 1085 0.31594669056979 1499 2919270 SGTC_189 3970-0742 2.116 µM 0.478130341391117 0.32382048788971 no 1086 0.316278718944468 1544 2891807 SGTC_1509 1326-1131 80 µM 0.478058769894573 0.323844802582447 no 1087 0.316304188177255 1521 768313 SGTC_103 0844-0104 51.839 µM 0.476868834720678 0.324249164489828 no 1088 0.316727762793856 1549 5375804 SGTC_313 3474-0040 5.03 µM 0.473114845635313 0.325526196477909 no 1089 0.318065622922577 1485 1043375 YIL048W NEO1 SGTC_2592 piperlongumine 83.33 µM 0.471873371031962 0.325948973307471 no 1090 0.318508588128057 1449 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2860 9025725 38.96 µM 0.471467099469505 0.326087375328746 no 1091 0.318653604531771 1473 40546248 SGTC_95 0471-0001 561.058 µM 0.469430980781025 0.32678136791952 no 1092 0.319380804030475 1434 4015405 SGTC_1670 st016595 4.04 µM 0.469373226404178 0.326801061732381 no 1093 0.319401441151287 1523 597879 SGTC_219 mitoxanthrone 164.414 µM 0.467799415942746 0.327337904957021 no 1094 0.319964019167178 1581 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1738 st035555 74 µM 0.467717378120245 0.327365898724576 no 1095 0.319993355972983 1539 5331140 SGTC_3159 9100096 49.47 µM 0.466832469353768 0.327667917845861 no 1096 0.320309871742513 1453 25236875 SGTC_265 mycophenolic acid 32.932 µM 0.466324066808052 0.327841486522667 no 1097 0.320491777250408 1584 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3346 9158254 43.5805 µM 0.466102334250114 0.327917197690036 no 1098 0.320571126266927 1520 17639500 SGTC_3312 9133330 71.43 µM 0.465049462065015 0.328276800161248 no 1099 0.3209480180487 1611 17617324 SGTC_2187 6125751 200 µM 0.464967130271565 0.328304926828705 no 1100 0.320977497765288 1541 874498 SGTC_2195 6536160 144.242 µM 0.464031964122156 0.328624472020514 no 1101 0.321312422467468 1453 3834386 SGTC_1553 gossypol 38.6 µM 0.462402877615198 0.329181428295897 no 1102 0.321896218056029 1511 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1717 st033143 58.0435 µM 0.462323025874064 0.329208737976451 no 1103 0.321924844857589 1645 674616 SGTC_1237 0330-0133 46.1 µM 0.460393939271064 0.329868771564851 no 1104 0.322616742083558 1513 X1237 YHR072W ERG7 SGTC_714 4296-0578 26.1 µM 0.457982411282672 0.330694617003228 no 1105 0.323482538876702 1603 1589775 SGTC_495 decylubiquinone 155 µM 0.457777405185615 0.330764860940491 no 1106 0.323556185197074 1490 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1100 amiodarone 5.07 µM 0.45683998541413 0.331086137317412 no 1107 0.32389303158139 1625 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_980 1473-0395 201 µM 0.456494254529195 0.331204659049395 no 1108 0.324017300723809 1505 768876 SGTC_2129 girgensonine 121.053 µM 0.453006469468445 0.332401268247769 no 1109 0.325272041502669 1621 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1004 4084-0029 199 µM 0.451832238707694 0.332804515475261 no 1110 0.325694921449706 1657 716894 YLR208W SEC13 SGTC_567 1080-0542 68.4 µM 0.451581710024416 0.332890575579953 no 1111 0.325785174309795 1593 5950415 SGTC_1354 1498-1681 81 µM 0.450410490067023 0.333293022731158 no 1112 0.326207241222898 1571 5754243 SGTC_2371 9071574 200 µM 0.448488427068239 0.333953885723707 no 1113 0.326900368263924 1542 45596039 SGTC_1070 indatraline 8.81 µM 0.447260292615547 0.334376425197055 no 1114 0.327343566558448 1528 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_86 0417-1630 471.922 µM 0.445645175095992 0.334932425650791 no 1115 0.327926786491296 1576 3634867 SGTC_930 2810-3379 265 µM 0.445152247334661 0.335102187041491 no 1116 0.328104866704946 1708 1015764 SGTC_2836 9010338 19.48 µM 0.444230455452551 0.335419737072692 no 1117 0.328437987680206 1431 2994051 SGTC_1530 rhein 70.4 µM 0.444170727755998 0.335440316852596 no 1118 0.328459577032106 1567 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_424 splitomicin 100 mM 0.443786137287435 0.335572843198707 no 1119 0.328598605968603 1521 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.443360920902478 0.33571939267582 no 1120 0.328752348742005 1612 6708739 YPR165W RHO1 SGTC_3233 9132340 49.47 µM 0.442422907812337 0.336042764245595 no 1121 0.32909160261592 1509 17682950 SGTC_2453 5731132 22.18 µM 0.442133356290341 0.336142609056312 no 1122 0.329196353996766 1686 1362040 SGTC_1552 6-methylflavone 10.6 µM 0.442104177162341 0.336152671411335 no 1123 0.329206910906788 1612 689013 SGTC_1627 st003713 25.6 µM 0.439553139591122 0.337032843942235 no 1124 0.330130393306651 1564 16195070 YER133W GLC7 SGTC_2318 6029776 164 µM 0.439242906727231 0.337139943128589 no 1125 0.330242769188655 1650 818325 SGTC_2938 9059746 27.26 µM 0.438945294548197 0.337242697784446 no 1126 0.330350587863068 1596 6471769 SGTC_2321 7390090 138.78 µM 0.434023087518022 0.338943912814393 no 1127 0.33213583782192 1493 649046 SGTC_1720 st037298 9.481 µM 0.433451811303894 0.339141571234732 no 1128 0.332343283642195 1560 597396 SGTC_579 4491-1009 110 µM 0.432875027121956 0.339341180305909 no 1129 0.332552781673757 1737 1271041 SGTC_384 k007-0144 5.16 µM 0.431972950552108 0.339653454474655 no 1130 0.33288053641599 1601 6824886 SGTC_1947 st076332 61.6 µM 0.431709407855061 0.339744706519533 no 1131 0.332976314458313 1588 24208416 SGTC_1148 3909-7663 27.7 µM 0.431321668159536 0.339878979031588 no 1132 0.333117248622205 1652 4084526 SGTC_2097 5376186 200 µM 0.429793216570307 0.340408472696438 no 1133 0.333673033884449 1664 742755 SGTC_1845 st056753 3.01 µM 0.429708629419891 0.340437784991278 no 1134 0.333703802675767 1518 5375839 SGTC_902 1120-0002 2.07 µM 0.428604558676972 0.340820471013798 no 1135 0.334105513721223 1531 3280475 SGTC_1862 st057513 3.81 µM 0.427680836334703 0.341140771740066 no 1136 0.334441751936954 1572 5393163 SGTC_2292 7671323 168.05 µM 0.427412130509884 0.341233966995172 no 1137 0.334539586768045 1560 937504 SGTC_2416 tofa 880 nM 0.42700332588005 0.341375771299844 no 1138 0.334688452623853 1488 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2910 7948405 25.97 µM 0.426438283526624 0.341571807512585 no 1139 0.334894255093485 1679 2971328 SGTC_133 0724-0033 378.92 µM 0.425476661028369 0.341905531784024 no 1140 0.33524461590424 1525 280309 SGTC_1109 tnp00067 928.257 nM 0.423607576182255 0.342554537739539 no 1141 0.335926014568672 1577 676295 SGTC_2868 9035608 32.47 µM 0.423473268088315 0.34260119173297 no 1142 0.335974999101461 1539 6462614 SGTC_803 4488-1585 147 µM 0.423152454781124 0.342712640913202 no 1143 0.336092016652257 1661 747204 SGTC_3289 9119912 71.43 µM 0.421852058236207 0.34316453328924 no 1144 0.336566502533232 1600 17014829 SGTC_358 0075-0058 9.45 µM 0.420208405607446 0.34373602934184 no 1145 0.337166607391065 1836 1069125 SGTC_3117 9124945 49.47 µM 0.420151838059416 0.343755704177719 no 1146 0.337187267841459 1502 17592065 SGTC_2850 9015429 58.44 µM 0.41968045994443 0.343919671293163 no 1147 0.337359450733366 1551 6457570 SGTC_2921 7974240 10.71 µM 0.418585434069129 0.344300685221168 no 1148 0.337759568325549 1648 2979074 YDR527W RBA50 SGTC_2651 TUB2.036 5 µM 0.417625337039923 0.344634880779201 no 1149 0.338110534457917 1673 15992207 YFL037W TUB2 SGTC_2770 toltrazuril 17.5 µM 0.416992795055915 0.34485512557453 no 1150 0.338341838864632 1676 68591 Kills coccidiodes. SGTC_1634 st006576 41 µM 0.416712955353448 0.344952579743233 no 1151 0.338444188551467 1736 3915356 SGTC_1375 2910-0797 186 µM 0.416096123528226 0.345167427726722 no 1152 0.338669833220643 1622 742508 SGTC_1414 3917-0015 5.4 µM 0.41607457123485 0.345174935484103 no 1153 0.338677718362339 1629 6618702 SGTC_1105 epirubicin 18.1 µM 0.414139041807853 0.345849426744365 no 1154 0.339386140872109 1560 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_844 0330-0132 15.3 µM 0.414089962237283 0.345866536313853 no 1155 0.339404111864543 1676 2828079 SGTC_2325 6158266 200 µM 0.41191189857982 0.346626144908282 no 1156 0.340201999635082 1590 3623240 SGTC_163 TUB2.036 7.546 µM 0.409697211942182 0.347399158709475 no 1157 0.341014037771611 1615 15992207 YJR013W GPI14 SGTC_1938 st074717 56.4 µM 0.408647013228472 0.347765942072603 no 1158 0.341399362024867 1555 17250979 SGTC_2105 5350118 200 µM 0.407063106513048 0.348319393189103 no 1159 0.341980819699967 1585 2133313 SGTC_2926 9010726 65.15 µM 0.406479762735942 0.348523307549005 no 1160 0.342195061789826 1576 2994293 SGTC_3207 9114163 49.47 µM 0.405142384631998 0.348990968223259 no 1161 0.342686426394612 1804 849233 SGTC_2060 5238662 140 µM 0.40330358002863 0.349634344617612 no 1162 0.343362454199441 1606 790130 SGTC_3060 1327-0027 12.5 µM 0.402673648785587 0.349854849717898 no 1163 0.343594160869077 1718 16000455 YPR107C YTH1 SGTC_2286 7945697 125 µM 0.402238340932542 0.350007257220178 no 1164 0.343754313857369 1547 1245733 SGTC_1369 1866-0067 208 µM 0.401696952152383 0.350196838886451 no 1165 0.343953533931801 1722 3531355 SGTC_1019 4262-0212 3.4 µM 0.401000091512634 0.350440918109485 no 1166 0.344210028267066 1667 4677213 SGTC_3139 9095020 49.47 µM 0.400805647608585 0.350509034169084 no 1167 0.344281610265258 1533 25236292 SGTC_1534 6-azauridine 81.6 µM 0.399657986552543 0.350911171623628 no 1168 0.344704220343441 1622 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_458 nppb 133 µM 0.398833141086976 0.351200298543785 no 1169 0.345008077887703 1765 4549 A chloride channel blocker. SGTC_2965 9082772 38.63 µM 0.398047054067716 0.351475919930096 no 1170 0.345297750594182 1791 16459634 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.394057740810846 0.352875872365645 no 1171 0.346769204931692 1631 4000243 SGTC_1238 0333-0287 48.8 µM 0.393740767967379 0.352987192041639 no 1172 0.346886219595059 1616 7226 SGTC_2963 9082507 9 µM 0.392737261489748 0.353339702707409 no 1173 0.347256773376477 1687 16459611 SGTC_2772 vinpocetine 57.06 µM 0.392720087942551 0.353345736508608 no 1174 0.347263116135223 1684 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3288 9119690 36.221 µM 0.392716941403769 0.353346842026174 no 1175 0.347264278260658 1580 17595618 YKL019W RAM2 SGTC_1990 st072050 59.8 µM 0.391850626803613 0.353651263514842 no 1176 0.347584292751586 1598 17233948 SGTC_1988 st071872 53.4 µM 0.391592841925516 0.353741866768108 no 1177 0.347679538839096 1730 16414116 SGTC_735 3076-0345 636 µM 0.391275474185534 0.353853422896281 no 1178 0.34779681274534 1743 2888990 SGTC_1489 4065-0444 182 µM 0.389501236106206 0.354477306161446 no 1179 0.34845269821212 1749 2877968 SGTC_941 3237-0776 460 µM 0.387984905818568 0.355010809846773 no 1180 0.349013601898173 1739 760008 SGTC_939 1165-0479 45.3 µM 0.387455646687561 0.355197090704492 no 1181 0.349209457196585 1699 1377347 SGTC_2174 5790901 200 µM 0.383772506162798 0.356494384697625 no 1182 0.350573533732678 1640 786020 SGTC_1486 3970-0793 4.53 µM 0.382259904930657 0.357027642956355 no 1183 0.351134295858018 1736 2844330 SGTC_2700 st077718 96.8 µM 0.38221540509292 0.357043335336725 no 1184 0.351150798066133 1621 904970 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.381581800758275 0.357266795190885 no 1185 0.351385792743133 1673 688801 SGTC_994 3910-0338 138 µM 0.380530523595376 0.357637668058756 no 1186 0.351775821541235 1732 3479481 SGTC_2499 avocadenofuran 51.48 µM 0.38045904763699 0.357662888458071 no 1187 0.351802345129824 1573 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1471 k673-0312 37 µM 0.379418667357708 0.358030058512516 no 1188 0.352188495262632 1676 24099884 SGTC_1805 st050013 60.3 µM 0.378202727807759 0.358459353250638 no 1189 0.352639999605157 1702 4037144 SGTC_2430 5571206 200 µM 0.377488025187154 0.358711766825257 no 1190 0.35290548091051 1804 1731771 SGTC_2426 5582046 32.21 µM 0.376379936395511 0.359103235721684 no 1191 0.3533172298572 1690 2251934 SGTC_3217 9129673 49.47 µM 0.376003698215713 0.359236187937832 no 1192 0.353457073326376 1669 17248312 SGTC_50 0929-0078 56.389 µM 0.375278168825824 0.359492618174169 no 1193 0.35372680022859 1709 1377751 SGTC_2241 6772625 37.8075 µM 0.374773015743482 0.359671196252254 no 1194 0.353914642170917 1611 2285411 SGTC_870 0573-2213 57.6 µM 0.373884526043504 0.359985363059336 no 1195 0.354245114681002 1615 3916321 SGTC_3140 9094243 49.47 µM 0.372561500664999 0.360453355414169 no 1196 0.354737415544931 1699 19291112 SGTC_157 1348-1695 65.819 µM 0.372512943315821 0.360470535536185 no 1197 0.354755488471205 1648 5380510 SGTC_2030 5175110 200 µM 0.372367171941642 0.360522112737108 no 1198 0.354809746182817 1729 2831986 SGTC_232 clozapine 119 µM 0.371127827684121 0.36096072311859 no 1199 0.35527116263582 1685 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2739 tacrine 100.86 µM 0.371116681625991 0.360964668597271 no 1200 0.35527531335455 1673 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2581 avocatin a 64 µM 0.370134263923905 0.361312482628495 no 1201 0.355641226642816 1659 6710728 A skin care supplement. SGTC_124 0136-0217 7.121 µM 0.369044066849321 0.361698588965892 no 1202 0.356047439422295 1761 3976905 SGTC_643 k048-0106 28.4 µM 0.367804536087485 0.362137754712175 no 1203 0.356509493228348 1734 6763920 SGTC_22 0964-0034 14.468 µM 0.366262808509719 0.362684242078474 no 1204 0.357084489405991 1651 138402 SGTC_908 3448-7491 47.7 µM 0.365544687844916 0.362938885806529 no 1205 0.357352427586317 1631 1203031 SGTC_1562 morin hydrate 59.1 µM 0.362947316501651 0.363860412312623 no 1206 0.358322119919311 1706 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_462 ag-879 158 µM 0.360891292504064 0.364590432191394 no 1207 0.359090356567027 1774 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_475 α-linolenic acid 10 µM 0.360063976823934 0.364884320897555 no 1208 0.359399645444533 1763 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_478 N-arachidonylglycine 10 µM 0.360038666742854 0.364893313091761 no 1209 0.359409108977411 1756 5283389 SGTC_2214 7179297 48.276 µM 0.358914075993779 0.365292933904985 no 1210 0.359829684581934 1741 769744 SGTC_2008 4012253 172 µM 0.356832065547994 0.366033157559506 no 1211 0.360608764793773 1671 603940 SGTC_1191 1487-1166 10.6 µM 0.356550878601336 0.366133167130341 no 1212 0.360714028301052 1764 3955771 SGTC_1954 st077032 68.9 µM 0.356245027888359 0.366241959172489 no 1213 0.36082853677513 1613 698907 SGTC_2236 dapsone 200 µM 0.356232998074013 0.366246238434389 no 1214 0.360833040912756 1738 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1686 st019653 115.5 µM 0.355060645500398 0.366663349006485 no 1215 0.361272079295502 1792 97252 SGTC_2843 9000894 45.46 µM 0.354943789200052 0.366704933875401 no 1216 0.36131585124356 1650 2242070 SGTC_2402 5553605 200 µM 0.354005642804995 0.367038842412587 no 1217 0.361667327191116 1761 6758546 SGTC_1976 st070609 63.5 µM 0.353888952738467 0.367080382213057 no 1218 0.361711053219389 1678 682556 SGTC_971 1315-0384 26.7 µM 0.353836828575712 0.367098938085543 no 1219 0.361730585736321 1655 6769120 SGTC_2025 5147754 141 µM 0.35166901923138 0.367870938978656 no 1220 0.36254324864783 1789 315777 YLR208W SEC13 SGTC_1093 fluphenazine 7.97 µM 0.351535905797969 0.367918360807849 no 1221 0.3625931701077 1730 6602611 An atypical antipsychotic. SGTC_2851 9015922 71.43 µM 0.351318231290339 0.367995911964277 no 1222 0.36267480949521 1781 2996893 SGTC_1899 st063254 59.6 µM 0.351112507295617 0.368069210442821 no 1223 0.36275197255068 1629 3093813 SGTC_2050 5263056 171 µM 0.35106659966215 0.368085567769405 no 1224 0.36276919236884 1832 763468 YGL055W OLE1 SGTC_1864 st057645 30.4 µM 0.350850348061101 0.36816262348876 no 1225 0.362850311439984 1767 688666 SGTC_2908 7930301 100 µM 0.350304529440159 0.368357135557761 no 1226 0.363055083183003 1626 2223178 SGTC_264 promethazine 12.5 mM 0.349468933574691 0.368654980204582 no 1227 0.363368644886012 1712 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1974 st069448 26.9 µM 0.348967092804289 0.368833897189093 no 1228 0.363557007278346 1819 6323587 YNR016C ACC1 SGTC_1071 trifluoperazine 6.31 µM 0.34863955836423 0.368950685568758 no 1229 0.363679962814204 1790 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3113 9123498 49.47 µM 0.348501872245899 0.368999783679212 no 1230 0.363731654000235 1729 8897275 SGTC_2720 fluspirilene 36.88 µM 0.346413031505651 0.369744914555011 no 1231 0.364516166486179 1759 3396 An atypical antipsychotic. SGTC_1415 3966-0071 78.1 µM 0.345952211620056 0.369909364123549 no 1232 0.364689314624371 1729 2893185 SGTC_295 k015-0027 31 µM 0.345894551762661 0.369929942468733 no 1233 0.364710981642289 1728 3887424 SGTC_2158 5657123 3.6195 µM 0.345511427247275 0.370066686021814 no 1234 0.364854960465068 1753 2858827 SGTC_573 3702-0553 84.7 µM 0.344430892822464 0.370452435290906 no 1235 0.365261129700514 1717 1222756 SGTC_1072 oxiconazole 14.9 nM 0.343688777029218 0.37071744508638 no 1236 0.365540176120578 1733 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1032 k061-1018 98.7 µM 0.343377532593786 0.370828608844546 no 1237 0.365657229787175 1861 4005393 SGTC_202 3594-0513 34.79 µM 0.342744517274692 0.371054729233303 no 1238 0.365895334522505 1741 708429 SGTC_1615 st002656 86.5 µM 0.342062286902567 0.37129847966252 no 1239 0.366152009035196 1691 1584458 SGTC_889 0919-1524 82.7 µM 0.342058523736279 0.371299824327282 no 1240 0.366153425011849 1689 3905452 SGTC_948 3448-0295 75.3 µM 0.341666166892171 0.371440030954101 no 1241 0.366301068170449 1683 678569 SGTC_1558 st069300 45.6 µM 0.3385347459692 0.372559637504667 no 1242 0.367480123813762 1829 24208000 SGTC_1409 3909-8004 61.9 µM 0.337624231709936 0.372885384947222 no 1243 0.367823189565826 1732 2119279 SGTC_3027 9089541 49.47 µM 0.336546270438334 0.37327115609125 no 1244 0.368229482745043 1715 9943819 SGTC_2110 5483698 200 µM 0.336452972847351 0.373304550579245 no 1245 0.368264654373793 1733 2848765 YHR062C RPP1 SGTC_353 1988-1175 58.3 µM 0.336089243827903 0.373434751068373 no 1246 0.368401784660405 1663 2788357 SGTC_81 0411-0046 9.971 µM 0.335969524403925 0.373477609011168 no 1247 0.368446924014589 1700 12925265 SGTC_504 lovastatin 124 µM 0.335957000903643 0.373482092346175 no 1248 0.368451646015879 1660 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2630 antimycin a 100 µM 0.334717587858616 0.373925879107735 no 1249 0.368919066410448 1669 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_535 2293-4129 48.2 µM 0.33466952754174 0.373943091053357 no 1250 0.368937195329511 1838 396118 YIL048W NEO1 SGTC_3021 9087658 49.47 µM 0.334268198275692 0.374086829784499 no 1251 0.369088592848452 1797 25237042 SGTC_2734 clemastine 41.6 µM 0.334244219468953 0.374095418507216 no 1252 0.36909763926075 1774 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2512 diallyl trisulfide 49.23 µM 0.334139069859542 0.374133081704648 no 1253 0.369137309593651 1737 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1053 3366-3204 134 µM 0.332025222177567 0.374890488351514 no 1254 0.369935106893572 1662 3632071 YPR165W RHO1 SGTC_1286 0929-0070 131 µM 0.331766959710074 0.374983058783205 no 1255 0.370032617420474 1792 1420408 SGTC_817 1391-0715 46 µM 0.330982658014045 0.375264224466462 no 1256 0.370328792443829 1685 1353946 SGTC_1381 2324-0066 62.1 µM 0.329409016088232 0.375828561886655 no 1257 0.370923276941431 1741 10885928 SGTC_1568 digitonin 820 nM 0.328243533808267 0.376246696967946 no 1258 0.371363767191489 1896 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2513 baicalein 25.65 µM 0.327450837347612 0.376531172327072 no 1259 0.371663460584816 1648 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2477 5967686 25.23 µM 0.327090177282697 0.376660624786401 no 1260 0.37179984047962 1685 776118 SGTC_2820 7989630 71.43 µM 0.325138176644918 0.377361500738363 no 1261 0.372538248238194 1891 2984098 SGTC_275 trichlorophene 5.69 µM 0.323246315302659 0.378041169059514 no 1262 0.373254353727655 1769 62616 SGTC_259 usnic acid 108.925 µM 0.319435405950764 0.379411417378432 no 1263 0.374698182977572 1826 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2154 5570129 200 µM 0.318968125502988 0.379579537152676 no 1264 0.374875341720438 1763 673366 SGTC_1515 3460-0031 42.1 µM 0.31711631079371 0.380246013072068 no 1265 0.375577674455511 1811 2876596 SGTC_1655 st012546 55.1 µM 0.31690055384271 0.380323688082081 no 1266 0.375659530883889 1771 720985 YLR208W SEC13 SGTC_2163 5671233 125 µM 0.315777316703033 0.380728144405046 no 1267 0.376085768236634 1861 701023 SGTC_3138 9097216 49.47 µM 0.312697819842695 0.381837680174886 no 1268 0.377255126040611 1885 25237486 SGTC_3224 9130643 49.47 µM 0.31258415785615 0.381878650975643 no 1269 0.377298307805023 1812 17644395 SGTC_99 0109-0120 622.8 µM 0.307616915904575 0.383670438161441 no 1270 0.379186923478603 1855 759414 SGTC_279 1273-0055 2.93 µM 0.307311733774534 0.383780605272532 no 1271 0.379303052642535 1894 2847562 SGTC_2182 6325192 200 µM 0.30684022213198 0.383950833821237 no 1272 0.379482495609498 1835 736248 SGTC_429 1112-0049 25.5 µM 0.305855622497269 0.38430637328183 no 1273 0.379857287907961 1711 2836170 SGTC_1524 corynanthine 62.1 µM 0.305256692398291 0.384522694910095 no 1274 0.380085328595163 1804 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_40 0327-0103 19.753 µM 0.304914548261095 0.384646286705928 no 1275 0.380215617580384 1718 409036 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.303582730569907 0.38512748712515 no 1276 0.380722905005142 1869 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1315 1237-0019 3.69 µM 0.303262274421436 0.385243297903729 no 1277 0.380844996936923 1866 825140 SGTC_1284 0929-0043 16 µM 0.303081261641232 0.38530871927553 no 1278 0.38091396700005 1778 1239883 SGTC_1612 st002233 45.4 µM 0.302864157350634 0.385387189092657 no 1279 0.380996693755475 1782 1035021 SGTC_1391 3442-0225 151 µM 0.300134743265092 0.386374103340643 no 1280 0.382037189410324 1785 5227075 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.299869561413649 0.386470028332419 no 1281 0.382138326471772 1853 5282309 SGTC_1466 k213-0079 57.5 µM 0.298269486277617 0.387048975141202 no 1282 0.382748745679402 1780 3657981 SGTC_201 4262-0159 12.803 µM 0.297864357698712 0.387195600625439 no 1283 0.382903346123865 1907 1341029 SGTC_2360 9040895 200 µM 0.296673594534277 0.387626658704815 no 1284 0.383357859201127 1748 4914414 SGTC_1909 st060837 51.5 µM 0.296466642587916 0.387701589771629 no 1285 0.383436868943867 1738 678937 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.295567332514649 0.388027251407394 no 1286 0.383780262193794 1661 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2160 5660466 132.927 µM 0.295558477069998 0.388030458567164 no 1287 0.383783644017886 1911 2859134 SGTC_1705 st027868 56.3335 µM 0.29546110212882 0.388065725170523 no 1288 0.383820831319505 1879 292948 SGTC_3154 9100113 49.47 µM 0.295307410706644 0.388121389977643 no 1289 0.383879527953139 1733 25237525 SGTC_2650 prasterone 100 µM 0.295041917441261 0.388217553207401 no 1290 0.383980929353115 1830 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2123 5259487 200 µM 0.295035670979118 0.388219815795448 no 1291 0.383983315196704 1875 2173474 SGTC_2920 7982904 15.77 µM 0.294029326542936 0.38858438248508 no 1292 0.384367746998932 1756 6456808 SGTC_2084 5306078 60.6385 µM 0.291826147720984 0.389382866621432 no 1293 0.385209776009356 1856 679340 SGTC_683 panaxydol 45 µM 0.291760837567526 0.389406543713918 no 1294 0.385234745064378 1885 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2753 fluvastatin 17.09 µM 0.290528477735238 0.389853391818197 no 1295 0.385705983866381 1817 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_547 1120-0019 610 nM 0.289484667210236 0.390231986726506 no 1296 0.386105255823576 1792 3676939 SGTC_2011 4012611 177 µM 0.288569590891186 0.390563974814425 no 1297 0.386455384440795 1741 2049887 SGTC_1692 fluoroquinolonic acid 71 µM 0.287418241266577 0.390981795785487 no 1298 0.386896047827332 1838 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_343 4130-2827 29.8 µM 0.287351640375294 0.391005968884338 no 1299 0.386921542878835 1746 1118244 SGTC_1202 1988-0068 29.6 µM 0.286648656444443 0.391261145788583 no 1300 0.387190677293855 1716 2850480 SGTC_2962 9082311 13.18 µM 0.283878247692676 0.392267234251004 no 1301 0.38825184342548 1730 16459453 SGTC_1017 4239-0030 168 µM 0.283145114176488 0.392533596380102 no 1302 0.388532799923269 1728 1149593 SGTC_1513 0337-0559 19 µM 0.28246006890273 0.392782532590519 no 1303 0.388795380429409 1735 775073 SGTC_293 4049-0273 38.5 µM 0.281829486637956 0.393011716451784 no 1304 0.389037129970507 1830 1380311 SGTC_1942 st076330 65.2 µM 0.28093767098466 0.393335908369418 no 1305 0.389379103221859 1861 24208414 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.280831299462549 0.393374581378804 no 1306 0.389419897886778 1762 6708561 SGTC_737 1950-0117 57.9 µM 0.27924884892878 0.393950029748906 no 1307 0.390026928998298 1934 5393513 SGTC_1902 st060212 70.5 µM 0.279162589358722 0.393981404177448 no 1308 0.390060026061607 1866 688944 SGTC_2541 muurolladie-3-one 83.07 µM 0.278015272583044 0.394398772899872 no 1309 0.390500317459896 1846 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2827 7993847 71.43 µM 0.277146996893064 0.39471471322697 no 1310 0.390833618156069 1829 2985692 SGTC_2176 5809774 33.9695 µM 0.275832684070612 0.395193085224195 no 1311 0.391338289454888 1959 2870539 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.274039356123229 0.395846059672872 no 1312 0.392027188541349 1821 2346 DNA damaging agent; causes G2/M arrest. SGTC_862 0452-0056 10.2 µM 0.272234830891049 0.396503406367731 no 1313 0.392720730827042 1913 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_681 1642-0006 26.6 µM 0.271166692056162 0.396892643351863 no 1314 0.393131414709928 1853 4446530 SGTC_2365 9042475 200 µM 0.271150903260254 0.396898397666936 no 1315 0.393137486166196 1819 6464479 SGTC_3112 9123419 49.47 µM 0.268449181330245 0.397883384934184 no 1316 0.394176793509252 1860 17015854 SGTC_1518 st038567 90.8 µM 0.2669831728987 0.398418131735342 no 1317 0.394741058533199 1856 77966 SGTC_2399 5884133 200 µM 0.266874170632632 0.398457899448902 no 1318 0.3947830222215 1780 722445 SGTC_224 benfluorex 43.875 µM 0.26645210066632 0.39861189479209 no 1319 0.39494552221198 1932 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_57 miconazole 162.5 nM 0.266150227313915 0.398722045198567 no 1320 0.395061756848273 1763 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_468 gf-109203x 121 µM 0.265923307805528 0.398804851048982 no 1321 0.395149137077771 1935 2396 A protein kinase C inhibitor. SGTC_3028 9087778 49.47 µM 0.264826781567318 0.399205051716407 no 1322 0.395571452279891 1780 17217395 SGTC_3115 9123671 49.47 µM 0.264350453335885 0.39937893091306 no 1323 0.395754943178643 1926 3286988 SGTC_1604 st002052 72.4 µM 0.26381423436515 0.399574696551339 no 1324 0.39596153279972 1854 6254834 YHR062C RPP1 SGTC_757 1066-0008 322 µM 0.26364360343748 0.399636996684875 no 1325 0.396027278080981 1908 6842497 SGTC_1764 st044502 93.5 µM 0.261996815682735 0.400238396857624 no 1326 0.396661948592296 1843 8407 SGTC_114 0364-0001 490.298 µM 0.260750043886736 0.400693870315665 no 1327 0.397142635576644 1791 4003655 SGTC_77 0828-0286 12.516 µM 0.259975563696717 0.400976873191475 no 1328 0.397441311503959 1948 745345 SGTC_3049 9092223 49.47 µM 0.259942977588099 0.400988781624717 no 1329 0.397453879557199 1872 8623917 SGTC_2665 lovastatin 100 µM 0.259200772565615 0.401260041692045 no 1330 0.39774016752419 1847 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1975 st070967 30.8 µM 0.259146997218847 0.401279697282417 no 1331 0.397760912229306 1987 261391 SGTC_1877 wortmannin 25 µM 0.258461411905721 0.401530309532886 no 1332 0.398025413111204 1956 312145 A covalent inhibitor of PI 3-kinase. SGTC_1638 st008370 60.6 µM 0.258409819005058 0.401549170697431 no 1333 0.398045319705769 1860 24207134 SGTC_61 0978-8327 98.565 µM 0.257481152318045 0.401888708819262 no 1334 0.398403681610929 2003 6150059 YHR072W ERG7 SGTC_1190 1486-1332 13 µM 0.257207057572324 0.401988937214866 no 1335 0.398509468046567 1864 4150046 SGTC_2240 6690706 185.951 µM 0.256804560018978 0.402136130425607 no 1336 0.398664824858809 1743 805876 SGTC_1830 st055982 50.3 µM 0.255967605220409 0.402442248910205 no 1337 0.398987925737625 1973 455313 An antimicrobial agent. SGTC_2362 9071156 126 µM 0.254271982949792 0.40306261056597 no 1338 0.399642721500023 1922 653133 SGTC_10 0279-0212 42.575 µM 0.252676033164568 0.403646728988805 no 1339 0.400259284893738 1861 39851 YBR002C RER2 SGTC_1271 0832-2808 169 µM 0.252497963565679 0.403711915906431 no 1340 0.400328093983067 1974 3663794 SGTC_2696 st077691 74.316 µM 0.25185056895345 0.403948933739556 no 1341 0.400578284210801 1870 757133 SGTC_2936 9038235 15.59 µM 0.250169843345789 0.40456442912429 no 1342 0.40122800270497 1855 4749415 SGTC_2786 7743617 45.45 µM 0.250050544555386 0.404608126308616 no 1343 0.401274130472518 1779 583674 SGTC_3039 9090270 49.47 µM 0.249937126059815 0.404649670740959 no 1344 0.401317985856177 1991 17173750 SGTC_1666 st014829 29 µM 0.248732001654411 0.405091166010316 no 1345 0.401784046437853 1841 3858230 SGTC_895 0964-0006 13.7 µM 0.247787119369864 0.40543740655232 no 1346 0.402149560729593 1970 6738897 SGTC_3179 9107801 49.47 µM 0.246167783067402 0.406030964480401 no 1347 0.402776176839322 1831 4818259 SGTC_2434 5670830 169.91 µM 0.244468997159247 0.406653876393335 no 1348 0.403433805154221 1862 1549830 SGTC_2192 5915882 198.485 µM 0.244352010185082 0.406696781965819 no 1349 0.403479102834164 1887 2876149 SGTC_2560 caryophyllene 100 µM 0.243143015853916 0.407140252341942 no 1350 0.40394730451554 1851 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2004 4023728 41.89 µM 0.242797244582191 0.407267106384718 no 1351 0.404081235109749 2006 360084 YDR527W RBA50 SGTC_2252 omeprazole 400 µM 0.241690607815938 0.40767316653082 no 1352 0.404509953861369 1957 4594 A proton pump inhibitor. SGTC_2302 7771753 200 µM 0.241479931210895 0.407750481717201 no 1353 0.404591584447684 1800 2203047 SGTC_1687 st020778 55.3625 µM 0.241314183361977 0.407811311242494 no 1354 0.404655809467221 1900 4259299 SGTC_2311 7694451 200 µM 0.239247861007339 0.408569838457055 no 1355 0.405456696160309 1911 2163142 SGTC_206 4546-0025 72.014 µM 0.23908337226466 0.408630235465379 no 1356 0.405520467476765 1887 6620745 YIL048W NEO1 SGTC_2558 carylophyllene oxide 100 µM 0.238914656418717 0.408692186836724 no 1357 0.405585880221697 1947 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3326 9140064 16.379 µM 0.23766503232401 0.409151111682855 no 1358 0.406070453391549 1825 1868434 SGTC_1396 3511-0007 98.6 µM 0.237488912232912 0.409215801870773 no 1359 0.406138759975185 1884 X1396 SGTC_302 1094-0063 18.9 µM 0.236588351537311 0.409546622958877 no 1360 0.406488078904628 1878 5440289 SGTC_106 0092-0003 11.579 µM 0.236528917805993 0.409568458216224 no 1361 0.406511135305024 1996 1072148 SGTC_1051 3253-3903 78 µM 0.236066462125235 0.409738368599218 no 1362 0.406690548928565 1907 5509239 SGTC_2987 9018338 71.43 µM 0.23579184227202 0.409839274431529 no 1363 0.406797099313451 1894 5055682 SGTC_3173 9105693 49.47 µM 0.235217743640529 0.410050239498492 no 1364 0.407019867434264 1939 17096658 SGTC_2873 9040596 71.43 µM 0.234767667758115 0.410215647911952 no 1365 0.407194531912971 1834 6463863 SGTC_2218 6965428 192.983 µM 0.234602273374711 0.41027643639423 no 1366 0.407258722448129 1972 675684 SGTC_2992 9074591 71.4286 µM 0.234463269205022 0.410327527175623 no 1367 0.407312672712181 1985 17741321 SGTC_2886 9058944 51.95 µM 0.234044821203882 0.410481336316329 no 1368 0.407475091256879 1912 4949929 SGTC_2273 7815444 169.05 µM 0.233992700861185 0.410500495181522 no 1369 0.407495322627561 2033 2824616 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.233295911504476 0.410756647787658 no 1370 0.407765816587194 1877 689007 SGTC_3038 9091290 49.47 µM 0.233107460886611 0.410825932251298 no 1371 0.407838980766727 1980 25236843 SGTC_610 4215-0184 155 µM 0.232919095318142 0.410895188226699 no 1372 0.407912115138574 1901 5605015 SGTC_1410 3909-8106 77.9 µM 0.232626349678888 0.411002826917155 no 1373 0.408025782238447 1985 1039210 SGTC_2811 7967822 32.47 µM 0.231866884377255 0.411282103464065 no 1374 0.4083207030349 1945 2232244 SGTC_3328 9140624 29.0385 µM 0.231670089124456 0.411354477901289 no 1375 0.408397132402265 1999 4904392 SGTC_323 4013-0906 34.3 µM 0.230139939566591 0.411917316332183 no 1376 0.408991515211312 2022 2910086 SGTC_316 k060-0003 58.6 µM 0.228820223642328 0.412402896103524 no 1377 0.409504323786448 1987 6152314 SGTC_2083 5306046 65.942 µM 0.227790339575161 0.412781927581094 no 1378 0.409904618593326 1876 539837 SGTC_612 0302-0167 22.4 µM 0.226351169445458 0.413311726066035 no 1379 0.410464151728482 1979 235821 SGTC_796 1234-0020 70.7 µM 0.226246378176897 0.413350308819966 no 1380 0.410504900526876 1888 46495034 SGTC_3067 9117431 49.47 µM 0.226059977672397 0.413418941078961 no 1381 0.410577386019803 1870 17150885 SGTC_2561 acetosyringone 100 µM 0.225301135493889 0.413698372399795 no 1382 0.410872508190786 2044 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_955 1216-0110 33 µM 0.22525852791905 0.413714063245233 no 1383 0.410889080248652 1856 3619719 SGTC_702 1488-0190 94 µM 0.224688112524255 0.41392414008643 no 1384 0.411110956503247 2040 949357 SGTC_2450 5739737 12.93 µM 0.224545057089076 0.413976829476477 no 1385 0.411166605685027 1907 2262825 SGTC_509 pifithrin 175 µM 0.223779673986351 0.414258757449077 no 1386 0.411464373356616 1961 4817 A p53 inhibitor. SGTC_619 1652-1634 108 µM 0.22373304534046 0.414275934485748 no 1387 0.411482515599561 1876 5400454 SGTC_3121 9125696 49.47 µM 0.223142698031787 0.414493420493029 no 1388 0.411712223897516 2060 1235365 SGTC_1480 1070-0044 41.2 µM 0.222936084726129 0.414569543752266 no 1389 0.411792625743639 1994 3124987 SGTC_1625 st003711 30.1 µM 0.222085422539983 0.414882989951679 no 1390 0.4121236928222 1977 24207034 YER133W GLC7 SGTC_1458 k015-0034 6.33 µM 0.221015865068299 0.415277170078918 no 1391 0.412540039944793 1823 3598957 SGTC_801 0866-0028 10.1 µM 0.218995850729255 0.416021868745158 no 1392 0.413326639980316 1898 6849771 SGTC_794 k038-0031 316 µM 0.21890805290037 0.416054243159597 no 1393 0.413360836649952 1883 6624242 SGTC_1812 st052057 4.327 µM 0.218760135716149 0.41610878716577 no 1394 0.4134184508944 1907 3645418 SGTC_3095 9117207 49.47 µM 0.217717500914803 0.416493301315241 no 1395 0.413824613499222 2042 17015229 SGTC_1236 0330-0013 258 µM 0.216920420882843 0.416787311043677 no 1396 0.414135181464266 1899 4617066 SGTC_2282 7944268 200 µM 0.216209336575751 0.417049639813651 no 1397 0.414412288064769 1984 2970414 SGTC_1199 1638-0010 4.46 µM 0.215966233854546 0.417139332225183 no 1398 0.41450703396503 1860 3111136 SGTC_3213 9129884 49.47 µM 0.215156534524668 0.417438100745396 no 1399 0.414822638849821 1844 17190742 SGTC_1244 0416-0015 52.5 µM 0.214883411733392 0.417538890263412 no 1400 0.414929109157843 1912 96201 SGTC_3208 9114115 49.47 µM 0.21378568936787 0.417944033367267 no 1401 0.415357092598378 1794 650895 SGTC_1739 st037196 92.5 µM 0.213635870253028 0.417999334788123 no 1402 0.415415512346332 2057 612214 SGTC_2354 9060492 162 µM 0.212305673510522 0.418490409671988 no 1403 0.415934284750073 2017 6471895 SGTC_1331 1472-0049 76.2 µM 0.211945307792285 0.418623469457584 no 1404 0.416074851469794 1891 24051409 SGTC_90 0870-0863 4.608 µM 0.211258511823878 0.418877084622918 no 1405 0.41634277752333 1882 1738164 SGTC_2313 7726885 200 µM 0.21117356533719 0.418908455406867 no 1406 0.416375918710986 1927 726423 SGTC_3193 9111931 49.47 µM 0.209633274263014 0.41947737499061 no 1407 0.416976953765335 1931 17087244 SGTC_2821 7996764 71.43 µM 0.205833007403312 0.420881753578877 no 1408 0.418460678520544 1950 2987135 SGTC_1461 k072-0203 53.8 µM 0.205564216758497 0.420981122808551 no 1409 0.418565665706997 2046 5418714 SGTC_839 0122-0028 230 µM 0.202633798765973 0.422064794520396 no 1410 0.419710635200964 1968 759448 SGTC_3294 9122953 26.2835 µM 0.202365648574939 0.422163986352408 no 1411 0.419815440636121 1974 16459826 SGTC_2369 9071472 200 µM 0.201505057216516 0.422482362288497 no 1412 0.420151837724502 1965 17296037 SGTC_3292 9120825 59.784 µM 0.200682655505448 0.422786657290116 no 1413 0.420473361356206 2090 24824900 SGTC_1039 k821-0043 94 µM 0.199263659260367 0.423311805132965 no 1414 0.421028252404669 2038 15992768 SGTC_2726 cimetidine 79.27 µM 0.199149989047871 0.423353878570258 no 1415 0.421072709348659 2070 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3078 9116413 49.47 µM 0.198075477202577 0.42375163719671 no 1416 0.421493005528032 2019 17177322 SGTC_589 1227-0070 34.1 µM 0.197906858486413 0.423814062882514 no 1417 0.421558969008528 1979 2841384 SGTC_582 0987-0078 156 µM 0.196919458907092 0.424179654320708 no 1418 0.421945282907948 2051 1625765 SGTC_2508 celastrol 40.54 µM 0.194993259665059 0.424893030280761 no 1419 0.42269911217522 2071 122724 Celastrol is a natural product and antioxidant. SGTC_2717 st081029 62.2815 µM 0.194192257463469 0.425189757367392 no 1420 0.423012672562945 2084 5292846 SGTC_1773 st048542 73.5835 µM 0.192112317744088 0.425960457702506 no 1421 0.423827113231491 1892 3237138 SGTC_697 0508-1955 564 µM 0.191929967798747 0.42602803913561 no 1422 0.423898531451811 2082 6243113 SGTC_2802 7925815 54.55 µM 0.191591609206208 0.426153445303726 no 1423 0.424031057818561 1937 1262923 SGTC_2796 7949634 45.45 µM 0.191201318623641 0.426298108349337 no 1424 0.424183935281193 1945 2971588 SGTC_1335 1486-0900 202 µM 0.190390919709049 0.426598518183295 no 1425 0.42450140628084 2050 X1335 SGTC_2034 5197015 53.07 µM 0.188869012051549 0.427162794832976 no 1426 0.425097740617031 2059 780676 SGTC_1876 myriocin 605 nM 0.188849776490417 0.427169927745007 no 1427 0.425105278853311 2090 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_633 0437-0093 97.7 µM 0.188034071212005 0.427472428666647 no 1428 0.425424971281614 1981 2831118 SGTC_1007 4101-0031 70 µM 0.187189067963214 0.427785839587067 no 1429 0.425756197923464 2074 1146276 SGTC_798 1287-0182 476 µM 0.18718260934907 0.427788235256787 no 1430 0.425758729790435 2089 1649755 SGTC_1343 1487-0095 224 µM 0.18696858983702 0.427867622223465 no 1431 0.425842630159609 2088 4560101 YGL055W OLE1 SGTC_903 1134-0042 114 µM 0.186354223582057 0.428095527345307 no 1432 0.426083493920949 1939 701009 SGTC_918 glabranin 770.725 nM 0.185001936211084 0.428597255867826 no 1433 0.426613758456159 1994 124049 Also referred to as licorice root. SGTC_1885 st057546 99.9 µM 0.184482325273472 0.428790073757912 no 1434 0.426817545788821 2062 702008 SGTC_2941 9056145 11.23 µM 0.182918535864644 0.429370469096419 no 1435 0.427430969377889 2119 2119517 SGTC_785 1270-0111 65.3 µM 0.182749172758572 0.429433336848399 no 1436 0.427497415559653 2129 6741994 SGTC_2376 9072922 81.32 µM 0.181943199465249 0.429732539427617 no 1437 0.427813650994119 2018 17087968 SGTC_2150 5556613 200 µM 0.181342570009872 0.429955538187797 no 1438 0.428049346933309 1993 743190 SGTC_3214 9129694 49.47 µM 0.179585175921761 0.430608142942179 no 1439 0.428739121684424 2090 17158655 SGTC_43 0570-0105 72.5 µM 0.179556948186834 0.430618626806235 no 1440 0.428750202813589 2008 1114046 YDL195W SEC31 SGTC_745 0469-0705 296 µM 0.17903811191446 0.430811332831042 no 1441 0.428953888085893 2096 3486736 SGTC_957 1187-1561 14.1 µM 0.178547614026897 0.430993528571686 no 1442 0.429146465646623 2101 1538454 SGTC_952 1185-0122 232 µM 0.176442863813308 0.4317755055795 no 1443 0.429973016202318 2044 678600 SGTC_2165 5727197 32.143 µM 0.175898608138969 0.431977756311015 no 1444 0.430186799423563 2001 1361712 SGTC_647 0140-0236 81 µM 0.175301037179615 0.432199840057117 no 1445 0.430421548419447 2031 990837 SGTC_17 0960-0276 49.807 µM 0.171979871309454 0.433434520429071 no 1446 0.43172667679027 2083 6821114 SGTC_922 1866-0035 480 µM 0.17121225774962 0.433719982218868 no 1447 0.432028434758844 1970 3156169 SGTC_1209 2323-2347 50.3 µM 0.170458402281747 0.434000361272422 no 1448 0.432324822860952 2136 5412760 SGTC_1182 1222-0449 220 µM 0.166214070928316 0.435579557700984 no 1449 0.433994243238102 2053 658318 SGTC_97 0535-0701 19.132 µM 0.165321157377115 0.435911917448694 no 1450 0.434345603383453 2059 2832013 YGL099W LSG1 SGTC_2472 5377652 49.4 µM 0.164819851438211 0.436098533100541 no 1451 0.434542889272879 1964 1610903 SGTC_1079 idarubicin 2.36 µM 0.164383708311741 0.436260902882986 no 1452 0.434714543998024 2145 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_899 1083-0020 478 µM 0.164173503102184 0.436339163082256 no 1453 0.434797279763149 2089 767123 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.163508227404451 0.436586864166576 no 1454 0.435059147897245 2103 94937 An inhibitor of serotonin biosynthesis. SGTC_2099 5377090 177.372 µM 0.162959962295735 0.436791017572752 no 1455 0.435274979333376 1987 2243829 SGTC_2211 7117706 200 µM 0.162454949822002 0.436979080213699 no 1456 0.43547380089113 2117 822771 SGTC_48 0382-0018 55 µM 0.162342046857711 0.437021126331851 no 1457 0.435518252606707 2133 762596 SGTC_3318 9139014 38.6185 µM 0.162088328206461 0.437115616121602 no 1458 0.43561814869828 1990 16643984 SGTC_990 3985-0011 41.3 µM 0.161420962765015 0.437364173182572 no 1459 0.435880928637827 2037 5399565 YGL099W LSG1 SGTC_3354 9151612 71.43 µM 0.159021801543074 0.438257932787354 no 1460 0.436825848622743 2112 27261949 SGTC_78 0336-0123 156.75 µM 0.158558038702484 0.438430734844916 no 1461 0.437008545366592 1919 6765896 SGTC_3209 9113616 49.47 µM 0.157384900633019 0.438867908597416 no 1462 0.437470756352492 2189 16649353 SGTC_399 oxolinic acid 75 µM 0.156362167890398 0.439249094188014 no 1463 0.4378737779912 2011 4628 A DNA gyrase inhibitor. SGTC_906 1165-0455 526 µM 0.155776433505988 0.439467430290684 no 1464 0.438104623583965 2066 3252859 SGTC_1221 2958-7315 257 µM 0.155706238126278 0.439493597288173 no 1465 0.438132289917483 2057 4562705 SGTC_147 4466-0538 29.23 µM 0.155252138113866 0.439662880251078 no 1466 0.438311273133267 2030 6742687 YHR072W ERG7 SGTC_3227 9130768 49.47 µM 0.154615909243131 0.439900077188761 no 1467 0.438562063533826 2076 17720899 SGTC_3136 9095672 49.47 µM 0.154553712573576 0.439923266323354 no 1468 0.438586581709063 2173 17217380 SGTC_2829 7992743 58.44 µM 0.154244119492452 0.440038696720001 no 1469 0.438708628041161 2179 16462845 SGTC_2991 9074669 71.4286 µM 0.154171351382196 0.440065828724825 no 1470 0.43873731519058 2092 17333109 SGTC_88 0180-0332 8.668 µM 0.153852292760335 0.440184794871988 no 1471 0.438863100491861 2121 3101745 SGTC_1853 st056710 91.2 µM 0.153151149830062 0.440446246267003 no 1472 0.439139539944352 2171 269167 SGTC_540 1187-0821 17.3 µM 0.152117543606786 0.440831718268271 no 1473 0.439547113717787 1946 847520 SGTC_244 nsc-207895 1.295 µM 0.151546176119495 0.441044827536289 no 1474 0.439772444076152 2059 42640 SGTC_1442 4112-3290 3 µM 0.150613395547555 0.441392773710327 no 1475 0.440140346911243 2130 704353 SGTC_334 1502-1024 68.5 µM 0.150366180606031 0.441484997518939 no 1476 0.440237860919582 2046 3296216 SGTC_793 0488-0545 106 µM 0.150136970836165 0.441570507312808 no 1477 0.440328276021181 1955 292548 SGTC_2594 a-mangostin 100 µM 0.149885836613783 0.44166419944564 no 1478 0.440427343111473 2125 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1021 4476-0760 85.3 µM 0.149775048951314 0.441705532693438 no 1479 0.440471047665336 1937 746768 SGTC_2945 9067681 61.76 µM 0.149024161532156 0.441985694457434 no 1480 0.440767283849437 2135 16456930 SGTC_1459 k035-0031 35.7 µM 0.145694295432602 0.443228440454394 no 1481 0.442081362450663 1962 3877128 YMR208W ERG12 SGTC_809 3998-0021 90 µM 0.14544537465273 0.443321363269978 no 1482 0.442179620862972 2166 715485 SGTC_1793 st048256 72.231 µM 0.145331794271109 0.443363764176499 no 1483 0.442224456502144 2160 672022 SGTC_2656 pseudo-anisatin 100 µM 0.14510236176841 0.443449416034416 no 1484 0.44231502680218 2072 6708809 A neurotoxin. SGTC_2385 9074692 200 µM 0.144674188280688 0.443609269040806 no 1485 0.442484059742961 1996 17046906 SGTC_231 b-estradiol 524 µM 0.144480352908815 0.44368163797645 no 1486 0.442560584887367 2023 450 A steroid. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.143697902516131 0.44397378691629 no 1487 0.442869513779518 2119 16725076 SGTC_2937 9044753 11.33 µM 0.140233810038357 0.445267562850955 no 1488 0.444237629643985 2132 6465530 YGL099W LSG1 SGTC_3195 9113082 49.47 µM 0.139874777359827 0.445401688655605 no 1489 0.444379465049587 2197 17018038 SGTC_1281 0884-0031 11.8 µM 0.1396435206995 0.445488083783257 no 1490 0.444470826473556 2061 1548255 SGTC_2288 7946289 167.31 µM 0.138953988771547 0.445745701224244 no 1491 0.44474325393386 2150 1246052 SGTC_780 0109-0199 192 µM 0.136453410180119 0.446680138917841 no 1492 0.445731426631271 2176 610414 SGTC_3283 9109332 35.8195 µM 0.135407438420877 0.447071094773437 no 1493 0.446144871644766 2160 17027281 SGTC_1868 st057644 42.7 µM 0.133513116083657 0.447779271735979 no 1494 0.446893796000526 2160 688665 SGTC_2694 st077685 81.9 µM 0.13231835083323 0.448226010745274 no 1495 0.447366246564136 2088 2838096 SGTC_3335 9143315 29.6265 µM 0.132214203377562 0.448264956018049 no 1496 0.447407433537268 2048 4899691 SGTC_177 1327-0068 8.361 µM 0.131326055418264 0.448597093467652 no 1497 0.44775869052029 2181 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2138 5575593 77.673 µM 0.130803430482497 0.448792554460972 no 1498 0.447965404591308 2090 762213 SGTC_1892 st058411 7.36 µM 0.130669296525114 0.448842722379297 no 1499 0.448018460935681 2171 3934738 SGTC_2830 7992007 71.43 µM 0.129803624430255 0.449166515116839 no 1500 0.44836089764893 2012 1952075 SGTC_768 0384-0033 77.3 µM 0.128908541962014 0.449501343998175 no 1501 0.448715008779898 1989 3965305 YMR134W ERG29 SGTC_354 2783-3500 4.88 µM 0.126603937483239 0.450363606170619 no 1502 0.449626940180583 2021 6740761 SGTC_668 1682-0499 62.6 µM 0.126434169296364 0.450427133842776 no 1503 0.449694127990434 2059 682214 SGTC_3072 9116419 49.47 µM 0.125529593435674 0.450765649724534 no 1504 0.450052149077702 2068 17170162 SGTC_180 1486-1293 102.781 µM 0.125475167780114 0.450786018369219 no 1505 0.450073691447737 2204 4140536 SGTC_1508 1080-0625 72.9 µM 0.124707610727082 0.451073288161292 no 1506 0.45037751597679 2191 767111 SGTC_1664 st014217 9.02 µM 0.123926074340586 0.451365816261334 no 1507 0.450686903871295 2205 3982782 SGTC_438 sphingosine 6.67 µM 0.123804672217913 0.451411259299383 no 1508 0.450734966191878 1969 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2310 7668677 200 µM 0.122649361544474 0.451843745023282 no 1509 0.451192382315381 2126 2197143 SGTC_1355 1499-0035 1.68 µM 0.121174553324481 0.452395916303805 no 1510 0.451776389540662 2104 1548538 SGTC_294 k038-0071 157 µM 0.119769921702542 0.452921898950889 no 1511 0.452332704697425 2098 24152826 SGTC_2137 5261020 140 µM 0.119763103603396 0.452924452279339 no 1512 0.45233540528717 2129 763655 SGTC_669 0108-0021 26.2 µM 0.119348964476295 0.453079548010682 no 1513 0.452499446322227 2266 17201 SGTC_1999 st074831 12.5 µM 0.119090288428445 0.453176426216231 no 1514 0.45260191234953 2055 17112523 SGTC_2493 resveratrol 26.09 µM 0.11741222439539 0.453804954736364 no 1515 0.453266698704242 2158 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1893 st059353 36.1 µM 0.115657293214679 0.454462398053896 no 1516 0.453962077055036 2059 3112488 SGTC_1 0258-0098 57.368 µM 0.114597274777081 0.454859569365086 no 1517 0.454382169945986 2095 6790032 YDR047W HEM12 SGTC_2126 5251174 33.877 µM 0.113388924253729 0.455312373269525 no 1518 0.454861110122962 2214 790722 SGTC_2960 9079389 5.97 µM 0.113033772892166 0.455445469827479 no 1519 0.455001889945286 2206 16457355 SGTC_3181 9108277 49.47 µM 0.112268253307824 0.455732373007015 no 1520 0.455305356411999 2156 17097298 SGTC_2443 5493264 126.67 µM 0.111400180589352 0.456057739208916 no 1521 0.455649508431855 2175 5340055 SGTC_3054 9094397 49.47 µM 0.111079817207326 0.456177823491227 no 1522 0.455776526610385 2151 2598354 SGTC_450 aminopyrene 156 nM 0.109283841776127 0.456851096652705 no 1523 0.456488681112547 2208 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_825 1988-2224 89.6 µM 0.109158897809242 0.456897940131467 no 1524 0.456538230117764 2125 1180859 SGTC_3001 9076041 71.4286 µM 0.108824733455984 0.45702322659917 no 1525 0.456670752930451 2193 16004211 SGTC_1689 st020265 53.493 µM 0.106741041078829 0.457804550204223 no 1526 0.457497211255721 2211 5758320 YPR016C TIF6 SGTC_598 3937-0236 20.2 µM 0.106529951029201 0.457883711937901 no 1527 0.457580946562877 2175 1379313 SGTC_2929 9013348 24.6 µM 0.105876321031938 0.45812884295044 no 1528 0.457840240765392 2137 2995952 SGTC_2009 4012297 12.05 µM 0.105450512245068 0.458288542693521 no 1529 0.458009168238383 2088 45595307 SGTC_1411 3909-8223 150 µM 0.10476552974208 0.458545459752167 no 1530 0.458280931382779 2240 X1411 SGTC_960 1222-0186 7.7 µM 0.104003417463202 0.458831326299864 no 1531 0.458583318268529 2152 3126296 SGTC_1702 st027038 51 µM 0.102525476085291 0.459385759231102 no 1532 0.459169796200872 2130 5521182 SGTC_881 0833-0569 170 µM 0.101718451765714 0.459688538658695 no 1533 0.459490077860752 2023 5418700 SGTC_1475 4092-1048 11.7 µM 0.100522458371433 0.460137294473332 no 1534 0.459964776968483 2123 2881759 SGTC_542 3381-0244 89.3 µM 0.100143525350565 0.460279486812893 no 1535 0.460115190378482 2226 1112843 SGTC_134 0269-0018 6.916 µM 0.0989213736440225 0.46073812641911 no 1536 0.460600349211973 2116 4378915 SGTC_2777 climbazole 1.536 µM 0.0981528741694799 0.461026549724771 no 1537 0.460905451331676 2251 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_69 0096-0274 206.684 µM 0.0979356573962597 0.461108076444101 no 1538 0.460991692782979 2176 6741392 SGTC_2421 5690543 90.72 µM 0.097012893136554 0.461454430414565 no 1539 0.461358077752446 2144 3397993 SGTC_158 k038-0087 26.446 µM 0.0968584178714534 0.461512414632814 no 1540 0.461419415607642 2117 X158 SGTC_3185 9108267 49.47 µM 0.0962667648798388 0.461734506522645 no 1541 0.461654353122726 2115 4910486 SGTC_1241 0364-0022 50.8 µM 0.0962430268093636 0.46174341745624 no 1542 0.461663779473797 2180 4563895 SGTC_2086 5274770 176.623 µM 0.0953840179519631 0.462065890034423 no 1543 0.462004905011067 2149 689278 SGTC_1920 st075728 45.7 µM 0.0950508826204925 0.462190956013579 no 1544 0.462137205674938 2248 3400306 SGTC_965 1291-5240 308 µM 0.0941585133390063 0.462525988512694 no 1545 0.46249161993286 2212 2834598 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.093734517374284 0.462685183543494 no 1546 0.462660025039113 2242 1273210 SGTC_2203 7227154 166.4 µM 0.0935247351835836 0.462763951321653 no 1547 0.462743349988506 2247 896304 SGTC_3307 9126885 69.2785 µM 0.0930914013963917 0.462926661552679 no 1548 0.462915474232248 2171 24824909 SGTC_1142 3253-1408 9.78 µM 0.0922548398809672 0.463240795171109 no 1549 0.46324778392414 2265 256655 SGTC_1155 4088-0394 48.2 µM 0.0919934106539445 0.463338968046553 no 1550 0.463351637464544 2100 2326248 SGTC_2545 solidagenone 89.61 µM 0.0868042314819411 0.465288082165143 no 1551 0.465413562043258 2286 6708572 An anti ulcer agent SGTC_2068 5226020 147 µM 0.08650145753248 0.465401833644258 no 1552 0.465533898736502 2204 1810509 SGTC_2400 5203494 178.7 µM 0.0857520838075229 0.465683383773874 no 1553 0.465831748841789 2256 6777674 SGTC_1347 1493-0251 600 nM 0.0850521738582754 0.465946365192394 no 1554 0.466109956099586 2251 3986378 SGTC_2792 7535235 81.82 µM 0.0844467959479008 0.466173839511277 no 1555 0.466350601172703 2150 1281891 SGTC_2842 9000675 19.48 µM 0.0842737672557153 0.466238858096409 no 1556 0.4664193844442 2112 2989072 SGTC_558 k064-0027 21.3 µM 0.0832778914892375 0.466613093457732 no 1557 0.466815289628231 2211 5088526 SGTC_2107 5363541 170.161 µM 0.0829152572553538 0.466749373380213 no 1558 0.466959461140339 2261 244052 SGTC_1138 3761-0006 1.03 µM 0.0821648301937589 0.467031400324228 no 1559 0.467257820144692 2253 12061087 SGTC_3098 9119039 49.47 µM 0.081907245592392 0.467128210088463 no 1560 0.46736023632628 2272 17161528 SGTC_2491 paeonol 100 µM 0.0817909703812735 0.467171911225438 no 1561 0.467406468304078 2156 11092 Increases levels of cortical cytochrome oxidase. SGTC_342 k048-0088 23.3 µM 0.0811760158614766 0.467403043684083 no 1562 0.467650986563023 2239 6820570 SGTC_1618 st003135 44.5 µM 0.0800165014749035 0.467838880401989 no 1563 0.468112065886682 2262 1270615 SGTC_2762 leflunomide 42.06 µM 0.0800069146797245 0.467842484035169 no 1564 0.468115878241953 2206 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3135 9127742 49.47 µM 0.0795746513824535 0.468004972597754 no 1565 0.468287778267592 2132 3643468 SGTC_413 propylparaben 100 µM 0.0784370793766845 0.468432613395257 no 1566 0.468740189648393 2154 7175 A pharmaceutical preservative. SGTC_1311 1190-0148 100 µM 0.0784323104147488 0.468434406240273 no 1567 0.468742086345718 2246 1961333 SGTC_517 1365-0151 113 µM 0.07643004897084 0.469187193134167 no 1568 0.469538481947596 2169 768657 SGTC_1987 st072290 61.9 µM 0.0748096320923114 0.469796499344342 no 1569 0.470183088997005 2153 54697379 SGTC_2528 xanthyletin 44.79 µM 0.0739125918338496 0.470133833299955 no 1570 0.470539968210952 2213 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1916 st067606 49.2 µM 0.0736178798733406 0.470244665068555 no 1571 0.470657221831119 2234 19590279 SGTC_2409 alverine citrate 63.97 µM 0.0727878122507854 0.470556839388232 no 1572 0.470987484822396 2223 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2838 9002687 71.43 µM 0.0726732102270931 0.470599940686749 no 1573 0.471033083652724 2201 6457060 SGTC_1412 3909-8563 178 µM 0.0726696515832438 0.47060127908199 no 1574 0.471034499602364 2278 23767530 SGTC_3133 9127736 49.47 µM 0.0723659959606288 0.470715484269231 no 1575 0.471155322556427 2286 27243420 SGTC_2461 5755302 26.15 µM 0.0712993724065613 0.471116661495438 no 1576 0.471579747353519 2279 2788904 SGTC_42 0133-0086 60.653 µM 0.0692719917730947 0.471879278043348 no 1577 0.472386559747878 2284 162923 Model of phenazepam hydroxylation. SGTC_19 0279-0214 38.434 µM 0.0686482291530296 0.472113932554872 no 1578 0.472634814037364 2280 3566274 YBR002C RER2 SGTC_1210 3013-0140 750 nM 0.068108195506072 0.472317096716825 no 1579 0.472849753218901 2297 905973 SGTC_350 k064-0020 19.8 µM 0.0670018816872251 0.472733321588063 no 1580 0.473290102599404 2292 2790705 SGTC_835 0312-0010 67.2 µM 0.0668123972918261 0.472804613688682 no 1581 0.473365526926054 2270 1626196 SGTC_1944 st076371 56.9 µM 0.0657229742328079 0.473214517880643 no 1582 0.47379919058138 2197 24208455 SGTC_3128 9127691 49.47 µM 0.0637527582886094 0.47395589922145 no 1583 0.474583547556507 2227 41316314 SGTC_3018 9082602 49.47 µM 0.061600997114585 0.474765697999318 no 1584 0.475440291434955 2223 17332089 SGTC_2526 patulin 37.61 µM 0.0601048664411181 0.475328816929538 no 1585 0.47603605705664 2237 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3309 9129340 25.759 µM 0.0585558425854995 0.475911895897565 no 1586 0.476652941403881 2243 17158987 SGTC_183 3914-0051 30.55 µM 0.0563532345799219 0.476741083598959 no 1587 0.477530205556827 2295 1596232 SGTC_2974 9094440 9.66 µM 0.0563213696861187 0.476753080116236 no 1588 0.477542897652567 2253 25236134 SGTC_2794 7785382 27.27 µM 0.0559941976137754 0.476876255301282 no 1589 0.477673214772179 2330 2205081 SGTC_3080 9117754 49.47 µM 0.0559335268623519 0.476899097136604 no 1590 0.477697381026658 2312 9550191 SGTC_39 0986-0283 58.349 µM 0.0545034644239566 0.477437520899988 no 1591 0.478267024241645 2293 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_524 r073-0010 27.8 µM 0.0538661893086036 0.477677470648252 no 1592 0.478520887281078 2284 2772106 SGTC_927 2425-1185 123 µM 0.0504651475763053 0.478958181192811 no 1593 0.479875861102565 2318 730375 SGTC_772 k072-0172 35.3 µM 0.0501856153046671 0.479063452881088 no 1594 0.479987237216734 2234 5861980 SGTC_1273 0849-0096 14.1 µM 0.0491784737258124 0.47944275386258 no 1595 0.480388532991917 2263 5286025 SGTC_3205 9113483 49.47 µM 0.0491108124500396 0.479468236540314 no 1596 0.480415493358613 2290 17018033 SGTC_1374 2889-5571 141 µM 0.0488567905862486 0.479563907333334 no 1597 0.480516711914533 2265 2853281 SGTC_1280 0880-0253 10.1 µM 0.0480858552887858 0.47985426744456 no 1598 0.480823909504866 2275 6836607 SGTC_1231 0242-0792 125 µM 0.0473834695598327 0.480118818798002 no 1599 0.481103801800818 2299 3707635 SGTC_561 1550-0330 72.9 µM 0.0449679041346812 0.481028699966578 no 1600 0.482066445926906 2287 6812934 SGTC_1982 st072467 71.9 µM 0.0440911844514058 0.481358962346326 no 1601 0.482415859870645 2228 3163533 SGTC_2576 guaiol 23.12 µM 0.0438449846279074 0.481451708713237 no 1602 0.48251398449667 2324 227829 SGTC_1336 1486-0901 104 µM 0.0428705809191866 0.481818787842807 no 1603 0.482902350103561 2255 5006114 SGTC_2618 avocadyne 43.43 µM 0.0404417808589941 0.482733836225004 no 1604 0.483870460585219 2290 3015189 SGTC_2433 5607874 27.82 µM 0.0396951795169143 0.483015136154561 no 1605 0.484168072418972 2334 2252428 SGTC_2892 9047358 58.44 µM 0.0396602933848535 0.483028280547859 no 1606 0.484181979021001 2309 6466771 SGTC_3043 9092303 49.47 µM 0.0395118478328338 0.483084212053957 no 1607 0.484241153844655 2309 25236084 SGTC_529 4076-0302 30.3 µM 0.0384752477422149 0.483474792787572 no 1608 0.48465438315382 2240 5816522 SGTC_1962 st076595 64.5 µM 0.0370564791194779 0.48400939650246 no 1609 0.485219986403508 2326 279619 SGTC_365 0121-0052 13.6 µM 0.0368349711466469 0.484092865151827 no 1610 0.485308295008533 2324 3101739 SGTC_1278 0874-0585 172 µM 0.0366664012265244 0.484156386147867 no 1611 0.485375499277989 2304 766306 SGTC_767 0929-0023 86 µM 0.0356874693862005 0.484525277920848 no 1612 0.485765781084884 2338 1204563 SGTC_1886 st057356 49.9 µM 0.0356334715742279 0.484545626353631 no 1613 0.485787309402325 2330 24207747 SGTC_1455 4262-0120 131 µM 0.0355743260052448 0.48456791470356 no 1614 0.485810890119848 2305 1529587 SGTC_443 clozapine 122 µM 0.0344309036130637 0.48499881010904 no 1615 0.486266770277752 2345 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1294 1000-1494 117 µM 0.0339870397711758 0.485166083655482 no 1616 0.486443742747921 2317 712797 YDL207W GLE1 SGTC_1824 st053723 68.6 µM 0.0339491350065276 0.485180368482703 no 1617 0.486458855839675 2305 675225 SGTC_411 enrofloxacin 100 µM 0.0319920147023888 0.485917956204085 no 1618 0.48723920949191 2343 71188 A bacterial gyrase inhibitor. SGTC_3097 9117246 49.47 µM 0.0316171698577561 0.486059231048253 no 1619 0.487388675334282 2349 16423892 SGTC_3319 9138450 16.7555 µM 0.0312559228454437 0.486195382676787 no 1620 0.487532720845839 2256 2029690 SGTC_1923 st058458 19.1 µM 0.0288736326199277 0.487093291786847 no 1621 0.488482687486332 2363 3534982 SGTC_699 0375-0592 111 µM 0.0278283887583577 0.487487275616341 no 1622 0.488899511885891 2360 762578 SGTC_1435 4092-0789 56.7 µM 0.0275493818802087 0.487592443775953 no 1623 0.489010776865567 2361 2248285 SGTC_1131 3454-3128 32.3 µM 0.0275199862396762 0.487603524146047 no 1624 0.48902249958475 2295 710982 SGTC_734 2023-0417 80 µM 0.0269427665921942 0.487821102803233 no 1625 0.489252691539015 2339 3935732 SGTC_1170 0310-0127 64.8 µM 0.0267232863617987 0.487903835199987 no 1626 0.489340219966055 2339 774975 SGTC_2616 abietic acid 100 µM 0.0259450977566839 0.488197175167873 no 1627 0.489650564665853 2371 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_738 1315-0003 72.4 µM 0.0258967254619131 0.488215409427032 no 1628 0.489669855937505 2350 6251474 SGTC_2969 9091408 28.7 µM 0.0258280163911869 0.48824130981187 no 1629 0.489697257725316 2256 4286311 SGTC_2706 st078239 82.5 µM 0.0254252009268132 0.488393155030198 no 1630 0.489857905085093 2359 15434492 SGTC_2381 9035592 200 µM 0.0251515913194952 0.488496295801308 no 1631 0.489967024628721 2255 4749657 SGTC_1205 4161-2785 76 µM 0.0250580086844874 0.488531573193934 no 1632 0.490004346935459 2250 3498106 SGTC_110 0850-0284 111.64 µM 0.0244523505780828 0.488759887353927 no 1633 0.490245895533766 2360 3906265 SGTC_861 0443-0273 110 µM 0.02414975961677 0.488873956065242 no 1634 0.490366576222715 2297 6149169 SGTC_1872 amphotericin b 148 nM 0.0218499467416096 0.48974095317352 no 1635 0.491283825971988 2354 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_250 brefeldin a 552.239 µM 0.0205592984240034 0.490227530935793 no 1636 0.491798604374823 2357 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1540 guanosine 70.6 µM 0.0198789263676637 0.490484038865298 no 1637 0.492069978073117 2360 6802 Guanosine is a purine nucleoside SGTC_1881 5652484 16 µM 0.0192582595408801 0.490718040686062 no 1638 0.492317540904256 2364 2255129 SGTC_1020 4335-0961 93.3 µM 0.0184290713587154 0.491030663531691 no 1639 0.492648280393739 2355 669075 SGTC_1186 1319-0216 26 µM 0.0183637907501862 0.491055276045614 no 1640 0.492674319182058 2377 4565136 SGTC_1420 4'-methoxyflavone 42 µM 0.0181827279063457 0.49112354169879 no 1641 0.492746540746947 2379 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2186 6124449 200 µM 0.0180951479094496 0.491156561850695 no 1642 0.492781474363194 2363 3834182 YLR033W RSC58 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0177766042875879 0.491276662373287 no 1643 0.492908534442589 2360 6708760 SGTC_2649 anisomycin 9.56 µM 0.0174419475634822 0.491402838871542 no 1644 0.493042022460605 2352 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2395 5646831 180.19 µM 0.0172319719953254 0.49148200694812 no 1645 0.493125778004285 2359 6808628 SGTC_3180 9109287 49.47 µM 0.0157687266632477 0.492033710365807 no 1646 0.493709448920812 2361 18891271 SGTC_336 4111-0029 111 µM 0.0155667406771848 0.492109868575775 no 1647 0.493790019780775 2307 3131175 SGTC_1796 st049173 110.4 µM 0.0133051901293297 0.492962598418086 no 1648 0.494692153715403 2378 94134 SGTC_1348 1493-0373 93.8 µM 0.0127360316994385 0.493177207894895 no 1649 0.494919195827512 2361 3010129 SGTC_143 4032-1194 15.74 µM 0.0118113901655585 0.493525861636904 no 1650 0.495288046632831 2387 1806963 SGTC_1312 1218-2183 165 µM 0.0116171219215612 0.493599114824564 no 1651 0.495365543131614 2387 6744073 SGTC_204 PMA1.184 62.41 µM 0.010153387405849 0.494151055438151 no 1652 0.495949454070622 2386 2252213 YGL008C PMA1 SGTC_961 1252-1571 372 µM 0.0101486332010735 0.49415284815822 no 1653 0.495951350626201 2383 6813498 SGTC_2754 granisetron 64.02 µM 0.00981061854238514 0.494280307348431 no 1654 0.496086192249502 2378 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2747 doxorubicin 7.63 µM 0.00909663341192191 0.494549540080296 no 1655 0.496371018371684 2393 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2335 9018011 154.17 µM 0.00909423898640444 0.494550442985311 no 1656 0.496371973569749 2388 6458208 SGTC_1500 4488-1866 171 µM 0.00797003136368605 0.494974369261145 no 1657 0.496820451174501 2388 2900003 SGTC_912 3474-0017 2.18 µM 0.00767506304755908 0.495085599514167 no 1658 0.496938122906403 2390 3360550 SGTC_1645 Cervolide 78 µM 0.00491354464201939 0.496126963944876 no 1659 0.498039787183206 2391 23173 A fragrance. SGTC_383 2324-0395 7.37 µM 0.00393353088204296 0.496496532369285 no 1660 0.49843075226663 2395 3146421 SGTC_3259 9138485 49.47 µM 0.00240546190952684 0.497072781223326 no 1661 0.499040360465847 2399 17646153 SGTC_1691 st019933 84.6 µM 0.00162759094663179 0.497366125934361 no 1662 0.499350685442868 2401 6176082 SGTC_2345 9052315 157.45 µM 0.00128137325914106 0.497496689351597 no 1663 0.499488806169843 2403 6469265 SGTC_3273 9137859 49.47 µM 0 0.497979914926665 no 1664 0.5 2406 2377234 SGTC_1700 st030840 7.9285 µM -0.000193272596512464 0.498052801271737 no 1665 0.499922895390088 2406 5499307 SGTC_392 N-ethylmaleimide 8.33 µM -0.000460744698161085 0.498153669604197 no 1666 0.499816189465936 2407 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2715 st079500 56.4 µM -0.00112108764730296 0.49840269678606 no 1667 0.499552750831142 2406 28246688 SGTC_1266 0828-0227 32.9 µM -0.00155831001941865 0.498567581540928 no 1668 0.499378324498886 2409 3913820 SGTC_2809 7964133 12.99 µM -0.00240386443787302 0.498886456636399 no 1669 0.499040997762988 2412 1253665 SGTC_2333 9017922 200 µM -0.00266526329832232 0.498985035408526 no 1670 0.498936715040761 2410 3163164 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.00277834513950934 0.499027680866684 no 1671 0.498891602080293 2411 688669 SGTC_2980 9014342 25.29 µM -0.00322131183661342 0.499194732703948 no 1672 0.498714884732592 2427 2996599 SGTC_1578 josamycin 24.2 µM -0.00330714169475913 0.499227100923107 no 1673 0.49868064375569 2412 5282165 A P450 substrate. SGTC_3093 9117344 49.47 µM -0.00343411011131774 0.499274983354905 no 1674 0.49862999097382 2425 24824913 SGTC_1746 st038117 42 µM -0.0041579291897938 0.499547950769213 no 1675 0.498341231026847 2423 2898218 SGTC_1556 plumbagin 1.48 µM -0.00437524846476187 0.49962990649053 no 1676 0.498254533968998 2417 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_511 blebbistatin 171 µM -0.00441328197796699 0.499644249739097 no 1677 0.498239360939002 2418 3476986 A myosin inhibitor. SGTC_2374 9071832 200 µM -0.00442086912240191 0.499647111013049 no 1678 0.498236334135827 2413 17381698 SGTC_2307 7538926 6.34 µM -0.00629235647460588 0.499647111013049 no 1679 0.497489729524103 2421 96582 SGTC_720 r052-1644 49.9 µM -0.00678391969448392 0.49946173208506 no 1680 0.497293628365615 2428 1422863 YOR257W CDC31 SGTC_3172 9105863 49.47 µM -0.00721532930064307 0.499299038456512 no 1681 0.497121525051012 2416 2348785 SGTC_1472 k841-0093 193 µM -0.00730408337195824 0.499265567444624 no 1682 0.497086118232459 2441 X1472 SGTC_1935 st074532 41.6 µM -0.00741446804746317 0.499223939087877 no 1683 0.4970420823108 2450 2829742 SGTC_109 0132-0036 33.701 µM -0.00773449649992017 0.499103249752368 no 1684 0.49691441309315 2416 67274 A color developer. SGTC_880 0833-0487 87.2 µM -0.00774946323411146 0.499097605489882 no 1685 0.49690844240902 2419 76075 SGTC_2571 chrysanthemic acid 100 µM -0.0081826850554781 0.498934228736907 no 1686 0.496735617392717 2433 2743 An insecticide. SGTC_2812 7970281 58.44 µM -0.00859363220137636 0.498779252381485 no 1687 0.496571678969916 2423 2233435 SGTC_678 1218-2179 85.9 µM -0.00940076855032994 0.49847486574301 no 1688 0.496249691195666 2427 6820081 YOR116C RPO31 SGTC_3249 9135183 49.47 µM -0.00945027760533367 0.498456194953401 no 1689 0.4962299408177 2451 4902779 SGTC_1038 k292-0204 154 µM -0.010675775675897 0.497994037916261 no 1690 0.495741062607025 2412 4454212 SGTC_3278 9139605 49.47 µM -0.0108038664707155 0.497945732752588 no 1691 0.495689964720273 2455 7958859 SGTC_807 1315-0151 48 µM -0.0112138324536107 0.497791127985312 no 1692 0.495526421867884 2424 4011080 SGTC_2256 7954252 200 µM -0.012765721858336 0.497205888725529 no 1693 0.494907352130659 2456 2972920 SGTC_818 4072-2707 53.5 µM -0.0129119334009573 0.497150750592539 no 1694 0.494849026971703 2429 882871 SGTC_49 0717-0965 32.132 µM -0.0136525384581149 0.496871460367228 no 1695 0.494553594369008 2551 5889349 YGL099W LSG1 SGTC_996 3970-0799 1.8 µM -0.0156704576982701 0.496110489245642 no 1696 0.493748647722356 2406 6615648 YGL040C HEM2 SGTC_692 k241-0027 77.8 µM -0.0165576898313803 0.495775912266728 no 1697 0.493394739275048 2437 3600480 SGTC_1115 galangin 695.678 nM -0.0168151774702915 0.495678813718526 no 1698 0.493292030869398 2434 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_614 0462-0418 107 µM -0.0168594511417967 0.495662118149587 no 1699 0.493274370733386 2423 5188303 SGTC_932 2857-0803 154 µM -0.0170099995823943 0.49560534650046 no 1700 0.493214319206794 2513 674898 SGTC_595 3909-8003 73.7 µM -0.0171213477226128 0.495563357298101 no 1701 0.493169904193963 2448 699517 SGTC_2662 daunorubicin 22.37 µM -0.018095300301217 0.495196083513137 no 1702 0.492781413577628 2403 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1230 0170-0365 3.77 µM -0.0181095262711379 0.495190718983812 no 1703 0.492775739166568 2461 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_671 0560-0003 407 µM -0.0190524830178669 0.494835137544403 no 1704 0.492399618799725 2462 3238678 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0213482463679534 0.493969441288142 no 1705 0.491483928779513 2450 2374 Ca(2+)-ATPase inhibitor. SGTC_2745 rifampicin 24.3 µM -0.0239329874829243 0.492994810253278 no 1706 0.490453030803499 2460 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_943 3253-1379 105 µM -0.024382254264549 0.492825408860633 no 1707 0.490273851581923 2470 668464 SGTC_2278 7948257 134.34 µM -0.025389298766777 0.49244569547964 no 1708 0.489872223352519 2452 1247028 SGTC_421 streptovitacin 30 mM -0.0257079495390041 0.49232554732079 no 1709 0.489745141569287 2580 91467 include heat shock SGTC_1485 3909-9022 254 µM -0.0267120966824463 0.491946935456084 no 1710 0.489344682409244 2443 714516 SGTC_1727 st034309 9.9045 µM -0.0278659672908043 0.491511879608914 no 1711 0.488884526032095 2477 870305 SGTC_62 0180-0423 3.232 µM -0.0283077207165056 0.491345323360845 no 1712 0.488708361413771 2478 30102 YGL099W LSG1 SGTC_1260 0700-1617 7.75 µM -0.0283327347590478 0.491335892250611 no 1713 0.488698386255614 2475 2853078 SGTC_992 3909-8734 162 µM -0.0291683774497114 0.491020830506035 no 1714 0.488365150818442 2479 4288319 SGTC_3103 9120822 49.47 µM -0.029663667290259 0.490834094375974 no 1715 0.488167644231959 2452 17141819 SGTC_2517 totarol 10 µM -0.0313082728380191 0.490214053339909 no 1716 0.487511846436455 2497 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3036 9090181 49.47 µM -0.0313567169828815 0.490195789519605 no 1717 0.487492529503121 2457 25236586 SGTC_491 tetrandrine 80.3 µM -0.0320211699044709 0.489945287678762 no 1718 0.487227584205231 2475 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3298 9116858 71.43 µM -0.0355742823516436 0.488605817501735 no 1719 0.485810907524099 2514 2506942 SGTC_2741 miltefosine 3.04 µM -0.0358500961211678 0.488501845022264 no 1720 0.485700943894262 2483 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_911 3456-4043 236 µM -0.0362790014790958 0.488340163737403 no 1721 0.485529946654095 2508 914281 SGTC_977 1348-1378 135 µM -0.0377782528437668 0.487775017253167 no 1722 0.484932241854481 2461 X977 SGTC_1959 st077091 55.8 µM -0.0377913409476749 0.487770083766684 no 1723 0.484927024182403 2466 821356 YKL052C ASK1 SGTC_2265 7929201 200 µM -0.0378348834454435 0.487753670682763 no 1724 0.484909665653373 2457 1265108 SGTC_3322 9139058 2.11 µM -0.0389828261631915 0.487320968112296 no 1725 0.484452040470932 2584 4908926 YPR165W RHO1 SGTC_656 4090-1979 187 µM -0.0399357813601587 0.486961774951472 no 1726 0.484072162223225 2467 22330961 SGTC_666 0272-0154 136 µM -0.0408882150936378 0.486602788911548 no 1727 0.483692506292274 2499 6870312 SGTC_1680 diphenhydramine 100 µM -0.0419987057771604 0.486184242650622 no 1728 0.483249864924267 2551 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1783 st039459 87.517 µM -0.0421483583202856 0.486127839447636 no 1729 0.483190215016471 2546 729761 SGTC_564 3555-0129 330 µM -0.0421969479789045 0.486109526337829 no 1730 0.483170847777553 2476 563260 SGTC_3299 9121982 43.1275 µM -0.0432161996436293 0.485725384172083 no 1731 0.482764595852248 2518 17594604 YPL160W CDC60 SGTC_1321 1326-2144 215 µM -0.0435242416127367 0.485609289910852 no 1732 0.482641820410265 2492 3513030 SGTC_2916 7875993 68.79 µM -0.0438021376629003 0.485504558031445 no 1733 0.482531061556436 2487 1299250 SGTC_1748 st037455 53.6035 µM -0.0461317059692676 0.484626643627955 no 1734 0.48160263759611 2533 580690 SGTC_2948 9070189 9.45 µM -0.048198908697025 0.483847665826942 no 1735 0.480778859956082 2511 6473636 YDL196W YDL196W SGTC_1065 prochlorperazine maleate 2.48 µM -0.0492098649409203 0.483466732480599 no 1736 0.4803760248534 2497 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3230 9131665 49.47 µM -0.0496097689311969 0.483316050812041 no 1737 0.480216680869025 2497 15943720 SGTC_764 1951-2361 146 µM -0.0514683975400976 0.482615761184404 no 1738 0.479476141786055 2501 5438930 SGTC_2761 levamisole 97.89 µM -0.051487180106116 0.482608684604334 no 1739 0.479468658548058 2515 26879 An alkaline phosphatase inhibitor. SGTC_1971 st069429 63.5 µM -0.0525520697818749 0.482207482369088 no 1740 0.479044403466866 2504 1246522 YGL099W LSG1 SGTC_2239 6685329 187.64 µM -0.0526435415700821 0.482173020773654 no 1741 0.479007961946244 2638 805680 SGTC_2523 spermine 47.74 µM -0.0531856271770977 0.481968795138689 no 1742 0.478792003628975 2515 1103 A DNA binding polyamine. SGTC_2822 7994718 71.43 µM -0.0534813236271251 0.48185739628363 no 1743 0.47867420546857 2491 1018011 SGTC_3296 9122258 64.045 µM -0.054397515495786 0.481512244848022 no 1744 0.478309229136523 2553 4730474 SGTC_2031 5180455 200 µM -0.0547840613901085 0.481366627886871 no 1745 0.478155249249849 2503 29949 SGTC_3130 9127414 49.47 µM -0.0549402975640163 0.481307772354019 no 1746 0.478093013764933 2487 1494646 SGTC_3198 9112019 49.47 µM -0.0550695373274973 0.481259086912885 no 1747 0.478041532497285 2524 45595555 SGTC_1448 4255-0083 152 µM -0.0551431619177671 0.481231352186253 no 1748 0.478012205098578 2561 5399660 SGTC_664 1222-0054 14.9 µM -0.0559858473089264 0.480913915171716 no 1749 0.477676540844327 2522 6813991 SGTC_2366 9070441 60.58 µM -0.0565949823402285 0.480684463388968 no 1750 0.477433915826396 2531 6837235 SGTC_2062 5245942 200 µM -0.0566300488555413 0.480671254566916 no 1751 0.477419948710897 2487 1376160 SGTC_2905 7799065 20.05 µM -0.0567314199003311 0.480633070336376 no 1752 0.477379572425819 2528 1296806 SGTC_552 k242-0005 476 µM -0.0567784375711928 0.48061535987996 no 1753 0.477360845274509 2569 4088318 SGTC_1732 st034308 51.822 µM -0.0581027237524965 0.480116548109174 no 1754 0.476833402409886 2489 830119 SGTC_933 2914-0560 114 µM -0.0589079065386046 0.479813279399166 no 1755 0.476512730241476 2509 463887 SGTC_3019 9081971 49.47 µM -0.0594631133108774 0.479604169899394 no 1756 0.476291622389886 2531 16451803 SGTC_2529 gangaleoidin 93.61 µM -0.0595021148586097 0.479589480818203 no 1757 0.476276090525092 2540 4565183 SGTC_1112 tnp00069 1.16933 µM -0.0606179623682185 0.479169233041861 no 1758 0.475831733964541 2634 145826 SGTC_152 4469-0003 551.229 µM -0.0606426263779895 0.479159944402313 no 1759 0.47582191251682 2512 697280 SGTC_3004 9076122 71.4286 µM -0.0615776868273368 0.478807802454658 no 1760 0.475449573273249 2550 44782551 SGTC_1009 4106-0057 9.87 µM -0.0624570379119523 0.478476655633568 no 1761 0.475099436944382 2500 2928005 SGTC_693 4161-2696 114 µM -0.0655050672247662 0.477328942475924 no 1762 0.47388593597068 2595 805759 SGTC_3343 9148379 18.9835 µM -0.0655187414197954 0.477323793974263 no 1763 0.473880492449952 2560 1955036 SGTC_1247 0448-0043 5.84 µM -0.0659585135608611 0.477158216407787 no 1764 0.473705427437132 2575 3089013 YGL099W LSG1 SGTC_1140 3229-1848 2.98 µM -0.0667406566135711 0.476863743342189 no 1765 0.473394083576256 2517 2849525 SGTC_2986 9022445 71.43 µM -0.0697298135801606 0.475738458034476 no 1766 0.472204355862165 2517 6459286 SGTC_1192 1488-0095 21.4 µM -0.0697549092164716 0.475729011444508 no 1767 0.472194368470668 2608 915875 SGTC_3219 9131112 49.47 µM -0.0699804172339958 0.475644125515617 no 1768 0.47210462310121 2537 17612988 YMR079W SEC14 SGTC_1626 st003712 1.76 µM -0.0718193597097057 0.474951950754252 no 1769 0.471372832892018 2629 24207035 SGTC_3083 9117465 49.47 µM -0.0722342717479247 0.474795788959596 no 1770 0.471207735745035 2618 16420915 SGTC_467 ro 31-8220 72.8 µM -0.0738881212726075 0.47417336294425 no 1771 0.470549703931463 2579 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1659 st012954 42.1 µM -0.0742747124463469 0.474027878449097 no 1772 0.470395898992649 2625 24207262 SGTC_712 r015-0009 80.6 µM -0.0751268061909459 0.473707225268756 no 1773 0.470056909915982 2599 6813872 YLR060W FRS1 SGTC_2308 7584454 197.62 µM -0.0756398924890369 0.47351415289359 no 1774 0.469852798870849 2563 893577 SGTC_1978 st071761 42 µM -0.0756933409510049 0.473494040802598 no 1775 0.469831536973581 2569 5147680 SGTC_1674 st016616 23.6 µM -0.0757148753890186 0.473485937640404 no 1776 0.46982297055852 2523 625830 SGTC_1031 k035-0009 16 µM -0.076141083255535 0.473325562767134 no 1777 0.469653427639033 2589 5180959 SGTC_1607 st000305 50.6 µM -0.0762918181889466 0.473268844772883 no 1778 0.4695934675068 2553 5457690 SGTC_1784 st039334 36.3 µM -0.0769382068698194 0.47302563014246 no 1779 0.469336351462959 2733 3496984 SGTC_1854 st056233 32.9 µM -0.0773351338949777 0.472876284640154 no 1780 0.469178470890708 2540 5393174 SGTC_2497 7-hydroxyflavone 100 µM -0.0775106306157333 0.472810254457639 no 1781 0.469108667354412 2676 5281894 SGTC_3116 9124943 49.47 µM -0.0776925335854173 0.472741814729296 no 1782 0.469036316745159 2550 41905195 YPL160W CDC60 SGTC_362 0310-0100 9.03 µM -0.0787711927551957 0.472335993314128 no 1783 0.46860730883998 2621 790235 SGTC_1166 k206-0078 225 µM -0.0796205238964658 0.472016471632983 no 1784 0.468269535664402 2537 5404595 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0799894488689622 0.471877686220543 no 1785 0.468122823831854 2615 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1857 st056007 79.3 µM -0.081597615161977 0.471272752308242 no 1786 0.467483348898637 2599 619834 SGTC_444 curcumin 90.4 µM -0.0819243369344823 0.471149859466066 no 1787 0.467353440705558 2620 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.0819574187667346 0.471137416247544 no 1788 0.467340287196519 2544 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2744 captopril 92.04 µM -0.082026752940775 0.471111337363897 no 1789 0.467312719683027 2568 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1356 1502-0781 85.8 µM -0.0828984261231286 0.470783482759826 no 1790 0.466966152753497 2538 567702 SGTC_3252 9135871 49.47 µM -0.0833773225606409 0.470603368158369 no 1791 0.466775759845708 2672 17682838 SGTC_218 alverine citrate 93.75 µM -0.0839951947128458 0.470370993201215 no 1792 0.466530126166141 2651 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1470 k295-0292 231 µM -0.0845354216273228 0.470167828032917 no 1793 0.466315370617774 2665 5045612 SGTC_368 fentichlor 4.58 µM -0.0845719298536587 0.470154098526414 no 1794 0.466300857913554 2619 7329 A pesticide. SGTC_2457 5731572 11.68 µM -0.086464342996543 0.469442475049238 no 1795 0.465548650026226 2567 2865357 SGTC_1096 rimcazole 32.2 µM -0.0899992857986937 0.46811345751863 no 1796 0.464143891188322 2562 18528119 A dopamine reuptake inhibitor. SGTC_1139 k015-0024 46.9 µM -0.0903866514049472 0.467967842640037 no 1797 0.463989981954041 2544 2766652 SGTC_3073 9114972 49.47 µM -0.0911455725487122 0.467682568498695 no 1798 0.463688460830098 2582 41905075 SGTC_15 0266-0086 27.098 µM -0.0919134067339712 0.467393960886492 no 1799 0.463383419759901 2584 1712902 YIL048W NEO1 SGTC_1619 st003326 88.7 µM -0.0919194128185479 0.467391703432945 no 1800 0.463381033779272 2614 2849032 SGTC_2153 5569715 200 µM -0.0922720363161061 0.467259167818539 no 1801 0.463240952676696 2570 2054701 SGTC_1289 0976-0073 69.1 µM -0.0936411907453974 0.466744597618712 no 1802 0.462697093935216 2688 3391136 SGTC_2109 5483026 200 µM -0.0940119461530692 0.466605265899558 no 1803 0.462549833554787 2614 759335 SGTC_2682 pyrogallin 40.03 µM -0.0947316803437014 0.466334797923274 no 1804 0.462263976925193 2590 822798 An ATP competetive kinase inhibitor. SGTC_2655 perillic acid 100 µM -0.094896143130861 0.466272996843811 no 1805 0.46219866001571 2570 5702197 An apoptosis inducer. SGTC_876 0720-0963 56.8 µM -0.0949464633339794 0.466254087908757 no 1806 0.462178675393492 2642 765861 SGTC_23 0213-0011 39.996 µM -0.0953194265388466 0.466113941070153 no 1807 0.462030556380752 2648 627608 SGTC_2185 6113692 200 µM -0.0957575795852948 0.465949303483879 no 1808 0.461856554531587 2669 874150 SGTC_337 1315-0038 354 µM -0.0968190605594193 0.465550472396443 no 1809 0.461435043454439 2610 1626437 SGTC_306 1672-3436 11.6 µM -0.0968941605959801 0.465522256306077 no 1810 0.461405223078666 2653 6797378 SGTC_3267 9137951 49.47 µM -0.0973362117051184 0.465356175296673 no 1811 0.461229699868474 2558 16643986 SGTC_1082 camptothecin 424.86 nM -0.0997947581896041 0.464432596895615 no 1812 0.460253634817956 2535 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3055 9094636 49.47 µM -0.100481073732923 0.464174809363611 no 1813 0.45998120387983 2690 25236176 SGTC_2601 securinine 100 µM -0.100878319682402 0.464025606358192 no 1814 0.459823526843281 2615 442872 A GABA receptor antagonist. SGTC_1473 k844-0725 134 µM -0.102690892669111 0.463344880206284 no 1815 0.45910415101365 2602 54682906 SGTC_916 4466-0038 42 nM -0.103024170339685 0.46321972675638 no 1816 0.45897189393231 2615 5722064 YGL116W CDC20 SGTC_330 1488-0319 80.1 µM -0.103368882267947 0.463090283308983 no 1817 0.458835104086204 2657 6846614 SGTC_2763 lisinopril 49.32 µM -0.104348786143251 0.462722339086806 no 1818 0.458446281727096 2573 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_195 4234-0266 16.654 µM -0.106919185460876 0.461757331898102 no 1819 0.4574265463204 2622 2303354 SGTC_1259 0671-0132 43 µM -0.107815634579186 0.461420829899859 no 1820 0.457070970292296 2626 X1259 SGTC_1493 4348-0038 111 µM -0.107867884372787 0.461401217633965 no 1821 0.457050246498793 2599 800424 SGTC_1703 st026983 48.3 µM -0.109075147790888 0.460948090481557 no 1822 0.456571443224992 2619 1104023 SGTC_964 1287-0107 19.4 µM -0.109411078570797 0.460822013189351 no 1823 0.456438223536348 2692 51516812 YPR165W RHO1 SGTC_1484 3473-2379 286 µM -0.109565217417149 0.46076416506401 no 1824 0.456377098506602 2592 671917 SGTC_417 st075190 100 µM -0.109911693172153 0.460634136158778 no 1825 0.456239704460999 2600 222757 SGTC_1462 k081-0014 26.5 µM -0.110018881638738 0.4605939102451 no 1826 0.456197200216602 2593 3270634 SGTC_1380 2291-0730 164 µM -0.110169711999653 0.460537306992387 no 1827 0.456137391174431 2663 2999191 SGTC_2111 5486399 200 µM -0.110995645433659 0.460227366900742 no 1828 0.455809899918193 2580 689674 SGTC_1147 3809-1045 12.3 µM -0.111951682330434 0.459868634320539 no 1829 0.455430858778356 2621 325925 SGTC_2705 st078069 42.8 µM -0.112428818199776 0.459689611401269 no 1830 0.455241703279319 2671 1530061 SGTC_1101 ebselen 5.29 µM -0.112556839603147 0.459641578746317 no 1831 0.455190952264629 2613 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_66 0109-0187 42.4 µM -0.112814809313364 0.45954479226702 no 1832 0.45508868858293 2568 759417 SGTC_1425 4048-4433 7.33 µM -0.112970084062199 0.459486536597502 no 1833 0.455027136405142 2624 23734946 SGTC_1756 st041558 35.5 µM -0.113591394727776 0.459253443221695 no 1834 0.454780854604487 2689 3955792 SGTC_1665 st014639 11.4 µM -0.114402654791577 0.458949108772293 no 1835 0.454459304797556 2644 981133 YIL048W NEO1 SGTC_2891 9063876 19.48 µM -0.114789784723803 0.458803890105585 no 1836 0.454305873070577 2638 6472478 SGTC_486 niguldipine 82 µM -0.114857442097748 0.458778511299773 no 1837 0.454279059031793 2585 1236 A calcium channel blocker. SGTC_972 1319-0219 195 µM -0.115201974518705 0.458649277124395 no 1838 0.45414251682949 2662 23903702 SGTC_252 miconazole 1.30953 nM -0.117227576225621 0.457889562373589 no 1839 0.453339857452611 2626 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_604 1000-0114 314 µM -0.118960151590744 0.457239870956877 no 1840 0.452653462980955 2674 1572745 SGTC_2533 agelasine 13.65 µM -0.119683549122251 0.456968640761221 no 1841 0.452366916287871 2695 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2383 9036125 200 µM -0.120736784493257 0.456573777253358 no 1842 0.451949761148063 2612 79580 SGTC_562 3772-2733 112 µM -0.122366836513702 0.455962746803672 no 1843 0.45130425086272 2666 2876874 YIL048W NEO1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.122594916550807 0.455877258511159 no 1844 0.451213940041516 2669 75037 A free radical scavenger. SGTC_706 4262-0057 46.9 µM -0.122807839425123 0.455797453225571 no 1845 0.451129633146036 2609 883298 SGTC_1270 0831-1170 17.3 µM -0.123859970309617 0.455403131954253 no 1846 0.450713073942935 2631 6764716 SGTC_3339 9145883 14.936 µM -0.12406085603917 0.455327848284861 no 1847 0.450633545509592 2702 2030670 SGTC_211 3455-0679 143.504 µM -0.126184255954742 0.454532184368529 no 1848 0.449793036836571 2682 748649 SGTC_3202 9113761 49.47 µM -0.127188724546937 0.454155861058768 no 1849 0.449395514705304 2821 4798415 SGTC_2689 tacrolimus 100 µM -0.127860112611362 0.45390434901168 no 1850 0.449129838706462 2728 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2855 9016525 58.44 µM -0.129202326936382 0.453401590892222 no 1851 0.448598777507862 2622 43811474 SGTC_2596 sinensetin 100 µM -0.13083451531848 0.452790316825398 no 1852 0.447953109196625 2690 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2708 st078559 56 µM -0.131174244385756 0.452663098244196 no 1853 0.447818734945305 2646 17250902 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.131654594776573 0.452483229393104 no 1854 0.447628750462197 2660 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2344 7990960 76.95 µM -0.131715447077798 0.452460443735348 no 1855 0.4476046834857 2678 140813 SGTC_1678 st019265 80.2 µM -0.132995882675916 0.451981031282433 no 1856 0.447098318361337 2703 5367020 SGTC_2867 9039098 71.43 µM -0.133164975923835 0.451917725695468 no 1857 0.447031454636469 2622 6463460 SGTC_1588 farnesol 29.9 µM -0.133231884067718 0.451892676781299 no 1858 0.447004997888496 2649 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_500 h-89 112 µM -0.133234974666289 0.451891519734873 no 1859 0.447003775812953 2823 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.133290912873526 0.451870577874267 no 1860 0.446981656975921 2695 279621 SGTC_944 3370-0224 231 µM -0.133672495781337 0.45172772638789 no 1861 0.446830777563299 2668 4580514 SGTC_1385 3091-4834 14.1 µM -0.134365300932813 0.451468380010361 no 1862 0.446556859312383 2748 4072814 SGTC_1781 st038725 66.3 µM -0.134998258189421 0.451231455343672 no 1863 0.446306625744236 2632 4270275 YIL048W NEO1 SGTC_3075 9116269 49.47 µM -0.135489589680857 0.451047555134387 no 1864 0.446112397296341 2792 17015205 YNL244C SUI1 SGTC_2405 ticlatone 3.52 µM -0.136017373262992 0.450850022997115 no 1865 0.445903773363056 2595 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.136650143917472 0.450613213680704 no 1866 0.445653669559764 2769 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.139070311588963 0.44970764836594 no 1867 0.444697294069026 2629 66535 A nucleotide analog. SGTC_1936 st074407 74.3 µM -0.13970107092846 0.44947167705458 no 1868 0.444448090113556 2641 809813 SGTC_2122 5258151 111.688 µM -0.140278348393587 0.449255729329525 no 1869 0.444220035320583 2690 2173356 SGTC_1418 3966-3099 2.4 µM -0.141034907986562 0.448972738582794 no 1870 0.443921182681925 2690 740335 SGTC_2352 9027995 87.8 µM -0.141118755228574 0.448941377157975 no 1871 0.443888063695495 2715 2997347 SGTC_2863 9028737 58.44 µM -0.14133625072519 0.448860028698778 no 1872 0.443802156550278 2779 6460917 SGTC_2349 9023730 187.07 µM -0.141704803601532 0.448722186117149 no 1873 0.443656590254557 2762 4126287 SGTC_107 0358-0022 2.6945 µM -0.143604124025202 0.44801191916788 no 1874 0.442906541957192 2731 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_16 erodoxin 22.806 µM -0.145213982664107 0.447410029291083 no 1875 0.442270963191434 2670 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2692 st077426 47.7 µM -0.145388796535385 0.447344677586636 no 1876 0.442201954874415 2754 25238571 SGTC_1045 1348-1485 165 µM -0.145830249265696 0.447179653066017 no 1877 0.442027697853597 2647 6810614 SGTC_492 tmb-8 126 µM -0.145872781310615 0.447163754155809 no 1878 0.442010909541691 2657 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3124 9127567 49.47 µM -0.146962925121721 0.446756276380669 no 1879 0.441580641990278 2808 17592030 SGTC_2693 st077581 40.7 µM -0.147944467163553 0.446389440229395 no 1880 0.441193297296448 2682 25238761 SGTC_2013 4024628 200 µM -0.14811980676061 0.446323914588467 no 1881 0.44112410916363 2798 5230760 SGTC_2751 anetholtrithion 17.25 µM -0.148769132116387 0.446081269913138 no 1882 0.44086790427283 2792 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2622 2-methoxyxanthone 59.94 µM -0.149520760049559 0.445800421276568 no 1883 0.44057136467271 2751 71034 A hepatoprotective. SGTC_3137 9097352 49.47 µM -0.15134150421925 0.445120206284455 no 1884 0.439853165341937 2964 44120435 SGTC_3024 9090631 49.47 µM -0.151744780235971 0.444969567476945 no 1885 0.439694118298248 2677 25236383 SGTC_1743 st037606 46.3785 µM -0.153044556246055 0.444484106286136 no 1886 0.439181569173671 2703 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1933 st074711 15.9 µM -0.153258969767672 0.444404031666871 no 1887 0.439097027868957 2645 17250958 SGTC_700 3453-2283 142 µM -0.153323247335542 0.444380027084614 no 1888 0.439071684348646 2827 565664 SGTC_988 1497-1057 103 µM -0.154125719740081 0.444080359410843 no 1889 0.438755304577404 2676 3533044 SGTC_2732 terfenadine 20 µM -0.154176947410045 0.444061230519963 no 1890 0.438735109074221 2666 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_132 0417-1715 25.805 µM -0.154634750786146 0.443890288250639 no 1891 0.438554636168939 2727 6769098 SGTC_1150 3909-7983 10.9 µM -0.156281137290699 0.44327561946383 no 1892 0.437905711953565 2709 23965914 SGTC_2202 7226349 200 µM -0.156711936334081 0.443114805623505 no 1893 0.437735939742954 2667 844334 SGTC_2196 6573537 42.6665 µM -0.156714617619432 0.443113804750423 no 1894 0.437734883119683 2770 2903087 SGTC_882 0843-0131 351 µM -0.156912487497654 0.443039944671442 no 1895 0.437656909087227 2668 5425421 SGTC_852 0418-0143 439 µM -0.157191714678646 0.442935719230788 no 1896 0.437546878928147 2738 5369229 SGTC_591 4299-0174 154 µM -0.158686144268451 0.442377969831507 no 1897 0.436958077559973 2714 5509088 SGTC_1565 sinapyl alcohol 95.1 µM -0.158765953487249 0.442348186723337 no 1898 0.436926636851268 2746 5280507 A phenol propionate derived from cinnamic acid. SGTC_2283 7944793 200 µM -0.159803896644132 0.441960878081845 no 1899 0.436517777227303 2736 2970533 SGTC_2923 7992654 58.14 µM -0.163401813265359 0.440618746751111 no 1900 0.435101037646485 2739 2985126 SGTC_1177 0983-0204 23.6 µM -0.165129981430074 0.4399743294027 no 1901 0.434420837583364 2813 766818 SGTC_464 bw-b 70c 158 µM -0.165222373887078 0.439939881602895 no 1902 0.434384477730496 2842 5353454 SGTC_1438 4092-1045 4 µM -0.166124824230025 0.439603434050065 no 1903 0.434029359339335 2693 1351342 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.166769625121794 0.439363068929843 no 1904 0.433775659791363 2841 5393153 SGTC_2636 apigenin dimethyl ether 100 µM -0.167220933910997 0.439194845961811 no 1905 0.433598106725153 2834 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2253 7938677 135.83 µM -0.16837660770328 0.438764124791094 no 1906 0.433143504856581 2914 2301972 SGTC_1068 loratadine 26.9 µM -0.169405883037436 0.438380573524724 no 1907 0.432738698195909 2751 3957 A H1 histamine antagonist. SGTC_2765 myclobutanil 7.74 µM -0.16948651337039 0.438350529712052 no 1908 0.432706989835621 2790 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2375 9072683 200 µM -0.171024881706595 0.437777383784701 no 1909 0.432102100526267 2705 16798029 SGTC_55 0767-0285 6.563 µM -0.171220164864338 0.437704636952583 no 1910 0.43202532617607 2813 3116166 SGTC_3241 9133421 49.47 µM -0.171241837566086 0.437696563573016 no 1911 0.432016805847339 2701 17018221 SGTC_1958 st076513 41.9 µM -0.171541364797925 0.437584988216081 no 1912 0.431899054018956 2693 732122 YGL099W LSG1 SGTC_1806 st050005 60.3 µM -0.171901995634389 0.437450658053454 no 1913 0.431757288826421 2710 5194765 SGTC_1118 chelidonine 707.474 nM -0.172772782900628 0.437126331195278 no 1914 0.431415015692861 2723 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2828 7998861 71.43 µM -0.172892862573677 0.437081610535646 no 1915 0.431367821005117 2772 2988188 SGTC_131 0141-0277 33.849 µM -0.174535398808589 0.436469970099299 no 1916 0.430722356726854 2872 1547771 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.174802195041645 0.436370635987385 no 1917 0.430617531750804 2828 5357218 A potent inhibitor of glutathione S-transferases. SGTC_427 1354-0053 47.3 µM -0.17484855851877 0.436353374253098 no 1918 0.430599315911102 2953 6813657 SGTC_221 trifluoperazine 10.304 µM -0.176221895592711 0.435842117851515 no 1919 0.430059809881951 2725 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_670 4204-0025 119 µM -0.177577297401127 0.435337643364932 no 1920 0.429527477599225 2836 719039 SGTC_7 0192-1582 4.227 µM -0.178656028181487 0.43493621975106 no 1921 0.429103899007855 2745 252616 SGTC_2041 5107442 45.335 µM -0.179599038276055 0.434585356228865 no 1922 0.42873367987486 2846 793005 SGTC_2641 levomentholum 100 µM -0.179734697360463 0.43453488610805 no 1923 0.428680426223057 2735 16666 SGTC_1816 st051957 91.6 µM -0.180924667957278 0.434092219514635 no 1924 0.428213353070156 2755 674121 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.182245024567443 0.433601146329803 no 1925 0.427695220049117 2869 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1611 st001856 99.4 µM -0.182631473494899 0.433457435796662 no 1926 0.42754359369141 2755 647478 SGTC_101 0490-5701 117.494 µM -0.183850672030091 0.433004104598478 no 1927 0.427065301538163 2709 4661669 SGTC_1386 3228-0095 33.8 µM -0.184317165260014 0.432830673003499 no 1928 0.426882324344336 2866 870181 SGTC_1855 st056195 39.6 µM -0.18536615308948 0.432440730443014 no 1929 0.426470927128638 2917 4028379 SGTC_1706 st031321 9.9705 µM -0.185431972645533 0.432416265383924 no 1930 0.426445116353159 2837 6103185 SGTC_1817 st052116 64.4 µM -0.188018730218414 0.431454976471536 no 1931 0.425430984217132 2874 4361398 SGTC_2299 7976368 114.88 µM -0.189031233567455 0.431078820930873 no 1932 0.425034168613674 2877 2979718 SGTC_2846 9008642 19.48 µM -0.189616141971748 0.430861549828699 no 1933 0.424804968613685 2872 2992898 SGTC_1799 st045822 46.1415 µM -0.189834706700182 0.430780366757874 no 1934 0.424719329183748 2850 3674992 SGTC_2074 5212007 75.395 µM -0.191698206262191 0.430088312824012 no 1935 0.423989305563013 2760 758611 SGTC_1447 4239-0816 81.9 µM -0.192559703735746 0.429768448135211 no 1936 0.423651902991145 2752 1341554 SGTC_594 1487-1584 10.8 µM -0.193162829650258 0.429544541428878 no 1937 0.423415724058601 2772 5013332 SGTC_35 0133-0054 64.071 µM -0.193316018932398 0.42948767447661 no 1938 0.423355740828596 2776 99677 SGTC_1049 3226-0134 66 µM -0.193791696046013 0.429311102865488 no 1939 0.423169494675754 2712 5702385 SGTC_1539 benzyladenosine 56 µM -0.194863887087067 0.428913156867884 no 1940 0.422749753064311 2749 92208 A nucleotide analog. SGTC_2525 harmine 47.85 µM -0.194907106823591 0.428897117282444 no 1941 0.422732835226735 2829 5280953 A monoamine oxidase inhibitor SGTC_3229 9132204 49.47 µM -0.195258220787649 0.428766817222776 no 1942 0.422595401241603 2735 17682924 SGTC_1159 4092-0538 61.2 µM -0.1973596448117 0.427987131545066 no 1943 0.421773053629093 2766 717301 SGTC_1809 st050081 57.6 µM -0.19745406404521 0.427952106007701 no 1944 0.421736112648109 2902 5036894 SGTC_1887 st057648 70.8 µM -0.198158771085902 0.427690707485358 no 1945 0.421460421853358 2901 688672 SGTC_1520 flindersine 88 µM -0.198694615549062 0.42749196676144 no 1946 0.421250818108855 3031 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1402 3909-7673 35.9 µM -0.200113988834757 0.42696562081263 no 1947 0.420695716568062 2726 5328014 SGTC_2032 5185112 25.99 µM -0.201912395952045 0.426298904642691 no 1948 0.419992605547746 2854 5718189 SGTC_892 0929-0076 29 µM -0.202507393358633 0.426078369935037 no 1949 0.419760039542385 2784 5751038 SGTC_71 0417-1750 47.813 µM -0.202576375969258 0.426052803149821 no 1950 0.419733078193652 2975 6811472 SGTC_2563 tomatine 8.54 µM -0.204192113770615 0.425454056987238 no 1951 0.41910168691629 2774 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1967 st070177 51.4 µM -0.204866101726297 0.425204347071683 no 1952 0.418838370184349 2946 5729214 SGTC_1167 k781-0610 148 µM -0.204929412581577 0.425180892186125 no 1953 0.418813637472716 2832 4525169 SGTC_649 1123-0311 367 µM -0.205049202646559 0.425136514071572 no 1954 0.418766841745015 2866 693629 YIL048W NEO1 SGTC_3325 9138760 55.175 µM -0.207466812876399 0.424241075833922 no 1955 0.417822654146492 2812 43844959 SGTC_2815 7968870 71.43 µM -0.2083848546844 0.423901152236615 no 1956 0.417464240488329 2785 2977326 YHR190W ERG9 SGTC_1219 1469-0211 33.1 µM -0.209863057531413 0.423353936724212 no 1957 0.41688727797188 2875 6822282 SGTC_1401 3807-4679 7.6 µM -0.212575489985531 0.422350207267141 no 1958 0.41582904532752 2763 3291456 SGTC_136 0097-0015 404.482 µM -0.214235441885765 0.421736194040941 no 1959 0.415181729500592 2764 4861337 SGTC_228 caffeine 993.056 µM -0.214602209995781 0.42160055278204 no 1960 0.415038735376303 2914 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_501 nsc-95397 161 µM -0.214934853827176 0.421477539693572 no 1961 0.414909055225096 2962 262093 SGTC_2781 5567276 71.43 µM -0.215012229046932 0.421448927109875 no 1962 0.414878892067697 2949 2853274 SGTC_674 0498-0004 451 µM -0.215247137698949 0.42136206277755 no 1963 0.414787320777384 2841 4231473 SGTC_2134 5324836 1.464 µM -0.215412647265964 0.421300863080924 no 1964 0.414722805181947 2826 699272 SGTC_387 norethindrone acetate 66.7 µM -0.215871660748325 0.421131145770143 no 1965 0.414543893860514 2832 541197 SGTC_406 estrone 100 µM -0.215910106346311 0.421116931419887 no 1966 0.414528909586792 2979 5870 A steroid. SGTC_607 4491-0986 66.8 µM -0.218987539298597 0.419979458456954 no 1967 0.413329877199033 2923 698981 YDR232W HEM1 SGTC_233 rapamycin 362 pM -0.219403121296406 0.419825903087574 no 1968 0.413168019409766 2822 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2226 7298446 200 µM -0.22074458027533 0.419330324428779 no 1969 0.412645658766699 2902 3283010 SGTC_1837 st055472 66.5 µM -0.221377868482689 0.419096411537865 no 1970 0.412399111669024 2958 676091 SGTC_2642 cholecalciferol 100 µM -0.221497326023488 0.41905229160966 no 1971 0.412352609211434 2890 9821465 A vitamin D precursor, similar to steriods. SGTC_1836 st055642 81 µM -0.221983292188852 0.418872817480644 no 1972 0.412163444887148 2810 8571 SGTC_3276 9139060 49.47 µM -0.22210842368162 0.418826607394995 no 1973 0.412114740241866 2777 4870619 SGTC_2263 7948595 193.29 µM -0.2223571771396 0.418734748007263 no 1974 0.412017922522103 2789 2971371 SGTC_2552 juarezic acid 87.02 µM -0.223030477095685 0.418486134823275 no 1975 0.411755893279938 2765 1549512 SGTC_1061 3448-9325 110 µM -0.22319448953772 0.418425578844875 no 1976 0.411692070245493 2766 723482 SGTC_3197 9113331 49.47 µM -0.223325129785088 0.418377345789886 no 1977 0.411641235182292 3007 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3023 9089636 49.47 µM -0.22496623069601 0.41777154762228 no 1978 0.411002772453954 2830 17249241 SGTC_1054 3429-0080 167 µM -0.224998370345509 0.417759685492409 no 1979 0.410990271019378 2974 1162877 SGTC_1497 4476-2978 41.3 µM -0.225456306663501 0.417590678090359 no 1980 0.410812156285987 2887 1528379 SGTC_1913 st060213 96.1 µM -0.225532244826749 0.417562653586127 no 1981 0.41078262184717 2973 688959 SGTC_1319 1306-0155 43.7 µM -0.226259774812601 0.417294184436314 no 1982 0.410499691099985 2803 3122360 SGTC_2159 5658611 73.75 µM -0.226688956238311 0.417135828317921 no 1983 0.41033280761509 2833 793844 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.227224642053901 0.416938193876323 no 1984 0.410124533601578 2836 77254 SGTC_165 k038-0023 64.381 µM -0.227686702424486 0.416767739460681 no 1985 0.409944905435237 2824 46368543 SGTC_2398 5228213 48.84 µM -0.229121063800447 0.4162387022939 no 1986 0.409387411171737 2996 80771 YMR134W ERG29 SGTC_1262 0737-0114 49.6 µM -0.230163077684681 0.41585447019261 no 1987 0.40898252570439 2933 765919 SGTC_216 k038-0035 28.382 µM -0.230359549889071 0.41578203205104 no 1988 0.408906195227252 2867 4444231 YPR107C YTH1 SGTC_29 0299-0004 12.984 µM -0.230494729836632 0.415732193664184 no 1989 0.408853679117842 2804 16871 A napthoquinone isolated from Swertia calycina. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.23078404043087 0.415625534668025 no 1990 0.408741290234259 2823 5106787 A p450 inhibitor. SGTC_1062 mesoridazine 14.2 µM -0.23139021269137 0.415402079695093 no 1991 0.40850583400664 2800 4078 A neuroleptic. SGTC_665 3914-0008 307 µM -0.233245680565262 0.414718263722843 no 1992 0.407785317962477 2819 1069549 SGTC_1239 0337-0584 35.4 µM -0.233333148724092 0.414686034481026 no 1993 0.407751359967497 2985 914301 YML130C ERO1 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.233853243885822 0.414494407779508 no 1994 0.407549456365912 3035 165506 SGTC_127 0180-0333 59.125 µM -0.23447019898614 0.41426711986296 no 1995 0.40730998308559 2791 771601 SGTC_1366 1683-0113 21.9 µM -0.235320916206597 0.413953760452511 no 1996 0.406979831050988 2816 708623 SGTC_2184 6075246 200 µM -0.235909680716339 0.413736922683142 no 1997 0.40675137806039 2883 2267320 SGTC_2495 cafestol 54.53 µM -0.236235614042111 0.413616895069846 no 1998 0.406624922726571 3039 16667697 An anti-infammatory. SGTC_466 geldanamycin 89.2 µM -0.237375226391297 0.41319728701547 no 1999 0.40618285351761 2895 5288382 HSP90 inhibitor. SGTC_1657 st012939 43.4 µM -0.240849822715701 0.411918545991298 no 2000 0.404835756527391 2983 24207257 SGTC_574 1315-0397 40 µM -0.242177888138504 0.411430029859165 no 2001 0.40432116392752 2826 6794277 SGTC_402 epigallocatechin gallate 10 µM -0.243887887652878 0.410801225210316 no 2002 0.40365882511569 2859 65064 An antioxidant. SGTC_3011 9081274 71.4286 µM -0.244164154215748 0.41069965734415 no 2003 0.403551843893931 2864 6625322 SGTC_2435 5706476 10.6 µM -0.244622647432464 0.410531108079421 no 2004 0.403374313311679 2998 5725375 SGTC_1197 1601-0112 267 µM -0.245193627572703 0.410321229968308 no 2005 0.403153255140585 2837 7350313 SGTC_1290 0986-0249 10.2 µM -0.245618562981583 0.410165050936516 no 2006 0.402988759089855 2897 53329 SGTC_663 1486-0733 13.9 µM -0.245632017209433 0.41016010625691 no 2007 0.402983551125971 2841 722445 YPR165W RHO1 SGTC_3264 9137442 49.47 µM -0.24636109934292 0.409892176357976 no 2008 0.402701358281103 3085 17015726 SGTC_3228 9131799 49.47 µM -0.248332512213768 0.409167914175405 no 2009 0.401938572791045 2904 17015818 SGTC_455 paf C-16 10 µM -0.248852428626772 0.408976957642999 no 2010 0.401737467138908 2828 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1360 1598-0022 39.8 µM -0.249566579303713 0.408714697362695 no 2011 0.401461273356193 2966 761525 SGTC_2136 5328288 199.296 µM -0.251187518049017 0.408119585669135 no 2012 0.400834567210426 2885 262395 SGTC_822 1487-0950 154 µM -0.25550779980688 0.406534475241177 no 2013 0.399165460060448 2992 1958375 SGTC_3007 9078383 71.4286 µM -0.256002329483511 0.406353129535929 no 2014 0.398974519286982 2890 6496995 SGTC_430 0958-0115 16.4 µM -0.256066712220901 0.406329521645212 no 2015 0.398949662516413 2883 6833180 SGTC_1760 st045453 10.4495 µM -0.256232978551657 0.406268556608631 no 2016 0.398885472608617 2983 3323419 YIL048W NEO1 SGTC_1682 st012968 530 nM -0.257375069304734 0.405849846574861 no 2017 0.398444623297776 2876 24207270 SGTC_280 3448-3607 3.04 µM -0.257397265080087 0.405841710288593 no 2018 0.398436056965928 2964 626179 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.257637673338382 0.405753586647057 no 2019 0.398343275917868 2846 6708784 An antioxidant flavonoid SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.260954124938199 0.404538403047711 no 2020 0.397063942373606 2875 2724278 An inhibitor of dopamine biosynthesis. SGTC_2951 9072950 58.06 µM -0.261511382924147 0.404334307704916 no 2021 0.396849086277835 2861 16488155 SGTC_1865 st057639 52.2 µM -0.262778223993958 0.403870425002012 no 2022 0.39636076029044 2829 688818 SGTC_2646 retinol 96.75 µM -0.263234892090865 0.403703238690765 no 2023 0.396184769424437 2943 445354 A vitamin A analog and teratogen. SGTC_1850 st056238 17 µM -0.263527972121912 0.403595951280346 no 2024 0.396071833311194 2832 5393177 SGTC_2954 9074818 52.69 µM -0.263985697824423 0.403428406765773 no 2025 0.395895469719397 3040 16648742 SGTC_2913 7966556 36.57 µM -0.266767719244998 0.402410466445935 no 2026 0.39482400505094 2984 2976516 SGTC_391 gliotoxin 8.33 µM -0.266852345055111 0.402379512232792 no 2027 0.394791424778215 3041 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_20 0481-0013 4.944 µM -0.26731576106508 0.402210015964278 no 2028 0.394613026303001 2891 182045 SGTC_947 3447-0010 211 µM -0.268085575910668 0.401928493743747 no 2029 0.394316724172301 2850 748350 SGTC_2017 5132927 60.65 µM -0.268906531602904 0.401628325314759 no 2030 0.394000805278565 2900 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2587 piperic acid 92.2 µM -0.270614545391387 0.401004005394669 no 2031 0.393343753762007 2960 5370536 SGTC_1253 0550-0034 176 µM -0.27087161331444 0.400910062758111 no 2032 0.393244889195472 3004 5969915 SGTC_1605 st000082 49.1 µM -0.270900565493756 0.400899482862467 no 2033 0.393233755041599 3001 1114022 SGTC_3242 9133940 49.47 µM -0.271620036209511 0.400636592509739 no 2034 0.392957095904602 3041 17248444 SGTC_2847 9005661 71.43 µM -0.272115401438453 0.400455615129404 no 2035 0.392766643797665 2951 2991449 SGTC_2557 derrustone 83.84 µM -0.272632430306226 0.400266745918792 no 2036 0.392567890093335 3012 629853 An antioxidant. SGTC_1382 3002-2117 298 µM -0.272992338355299 0.400135286272093 no 2037 0.392429552539208 3047 1497314 SGTC_100 0086-0128 49.5915 µM -0.273949182149604 0.399785845550574 no 2038 0.392061837437965 2920 93297 SGTC_1320 1313-0481 95.3 µM -0.274045563164316 0.399750651510154 no 2039 0.39202480354847 3059 6813365 YLR208W SEC13 SGTC_545 4218-0007 221 µM -0.27437298864489 0.399631096438096 no 2040 0.391898999366323 3015 2840508 SGTC_802 4112-3352 742 µM -0.276063905109731 0.399013830729215 no 2041 0.391249491655644 3041 704594 SGTC_1318 1280-3875 124 µM -0.278566220165813 0.3981008291982 no 2042 0.39028886963888 2957 373245 SGTC_1994 st072947 40.9 µM -0.27874983342793 0.398033857460608 no 2043 0.390218408028571 3007 5286565 YDL195W SEC31 SGTC_2479 5617353 43.85 µM -0.279936871430031 0.397600965676987 no 2044 0.389762969174868 3057 2731746 SGTC_3192 9110362 49.47 µM -0.280167461744669 0.397516888071091 no 2045 0.389674514571599 2849 16649480 SGTC_526 4469-0568 170 µM -0.2828263076445 0.396547767266154 no 2046 0.38865499337302 2895 2901964 SGTC_3215 9129942 49.47 µM -0.282893799289988 0.39652317557324 no 2047 0.388629123983929 3033 17682944 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.284737212500131 0.395851657075706 no 2048 0.387922739380212 2953 688788 SGTC_936 3005-4620 401 µM -0.285061707828017 0.395733481856577 no 2049 0.387798433071678 3114 777207 SGTC_3041 9091929 49.47 µM -0.285427731059883 0.395600194443189 no 2050 0.38765823222788 3089 25236887 SGTC_1810 st050138 53 µM -0.285740890287536 0.395486167155639 no 2051 0.38753829193741 3020 3444541 SGTC_2973 9094665 17.96 µM -0.287192481205326 0.394957732026108 no 2052 0.386982471535561 3126 25237061 YIL048W NEO1 SGTC_370 0180-0345 38.7 µM -0.287952793906868 0.394681025872846 no 2053 0.386691436914788 2835 3989527 SGTC_284 0988-0104 32.6 µM -0.2887091043516 0.394405828993625 no 2054 0.386401997497068 2999 4666532 SGTC_2814 7977482 42.97 µM -0.288867246016212 0.394348293019765 no 2055 0.386341484788403 3070 6456762 SGTC_569 4130-2812 160 µM -0.28891015361894 0.394332682536266 no 2056 0.386325066724991 2914 743552 SGTC_1797 st048695 56.8 µM -0.289197229870641 0.394228243895876 no 2057 0.38621522578589 3050 592262 YIL048W NEO1 SGTC_2746 daunorubicin 9.88 µM -0.289691701985116 0.394048372257126 no 2058 0.386026052553993 2938 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3254 9136651 49.47 µM -0.290310196644622 0.39382341737341 no 2059 0.38578946940344 2951 16454030 SGTC_2223 6903751 107.57 µM -0.29088224640425 0.393615386662058 no 2060 0.385570689908036 3018 5598863 SGTC_2505 galangin 7.89 µM -0.292016229002618 0.393203094142972 no 2061 0.385137107781796 2872 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2788 5282734 71.43 µM -0.293809536956373 0.392551329212262 no 2062 0.384451723567369 3083 743706 SGTC_3247 9135149 49.47 µM -0.293815406861669 0.392549196330852 no 2063 0.384449480740461 2900 8934436 YOR116C RPO31 SGTC_1851 st056236 18.9 µM -0.294496243716097 0.392301830218065 no 2064 0.384189366652617 3099 5393171 SGTC_875 0709-0210 25.7 µM -0.295412455601972 0.391969014795953 no 2065 0.383839409734767 3055 6251364 SGTC_859 0439-0102 54.6 µM -0.295735882269167 0.391851548405863 no 2066 0.383715896066922 3064 610143 SGTC_1506 4226-2149 212 µM -0.295816836040412 0.391822148082761 no 2067 0.383684982414706 3022 991114 SGTC_557 1315-0110 16.2 µM -0.296502200016579 0.391573266321678 no 2068 0.383423293547565 2914 6833801 SGTC_784 4579-0127 173 µM -0.296760042261068 0.391479645465126 no 2069 0.38332485677928 3119 1948547 SGTC_2266 7929956 200 µM -0.297498073721068 0.391211705762874 no 2070 0.383043139204853 2877 2967153 SGTC_2887 9044784 58.44 µM -0.298193244395062 0.390959373723736 no 2071 0.382777838791382 2941 6465546 SGTC_2093 5331342 194.4 µM -0.298626962738583 0.390801966515293 no 2072 0.382612345193586 3080 33839 SGTC_1522 st012842 45.6 µM -0.299855862067191 0.390356065526709 no 2073 0.382143551450736 2852 3491067 YOR116C RPO31 SGTC_3050 9093513 49.47 µM -0.30013149171115 0.390256074237816 no 2074 0.382038429463846 2940 25236664 SGTC_3189 9110682 49.47 µM -0.300682737862732 0.390056118209369 no 2075 0.381828216593955 3048 17122418 SGTC_2082 5219693 150 µM -0.303542254769881 0.389019340516094 no 2076 0.380738325394817 2934 2834649 SGTC_1613 st002381 52.1 µM -0.304719892913506 0.388592592335735 no 2077 0.380289748687468 2953 551167 SGTC_1332 1480-0653 17.5 µM -0.305942329062136 0.38814975261036 no 2078 0.379824278124861 3083 5749438 SGTC_1089 terbinafine 2.25 µM -0.307687316852907 0.387517865343279 no 2079 0.379160135766254 3053 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_739 1486-1183 203 µM -0.307750434982409 0.38749501485673 no 2080 0.37913611967546 3079 4346692 SGTC_962 1254-0300 21.5 µM -0.309087085303106 0.387011202572481 no 2081 0.378627641479068 2916 7340576 SGTC_2245 6637752 200 µM -0.310025276274542 0.386671720910635 no 2082 0.378270867509904 3073 681890 SGTC_2320 7373003 200 µM -0.310505933225275 0.386497830169703 no 2083 0.378088124124925 3017 5415828 SGTC_981 1488-1094 54.9 µM -0.311978261777549 0.385965317184275 no 2084 0.377528522000423 2903 3449522 SGTC_2462 5162487 171.77 µM -0.312771885778741 0.385678367639259 no 2085 0.377226988190567 2925 2259986 SGTC_771 0250-0039 27.3 µM -0.312881016774527 0.385638914183144 no 2086 0.377185530217004 2972 3005115 SGTC_620 0109-0052 432 µM -0.312899457138135 0.385632247669017 no 2087 0.377178525013344 3101 493037 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.313761283558593 0.385320720054738 no 2088 0.3768511758561 3013 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_198 3454-2873 16.191 µM -0.314466576131038 0.385065830352987 no 2089 0.376583349088823 2980 710957 SGTC_1953 st076800 12.1 µM -0.315004677277678 0.384871396299525 no 2090 0.376379051286233 2983 297591 SGTC_571 k831-0106 44.2 µM -0.315255631424234 0.384780728016256 no 2091 0.376283784789149 3073 4783639 SGTC_2065 5221596 34.26 µM -0.316254851479741 0.384419778119094 no 2092 0.375904538522834 3097 788581 SGTC_3171 9103192 49.47 µM -0.316522588528374 0.38432308003303 no 2093 0.375802941331534 3054 13018434 SGTC_2898 9056270 58.44 µM -0.316963955090491 0.384163688219692 no 2094 0.375635476386468 2969 19154699 SGTC_1337 1486-1011 40.3 µM -0.318512105167373 0.383604755921043 no 2095 0.375048256908629 2981 X1337 SGTC_2519 cryptotanshinone 88.04 µM -0.318576609962122 0.383581472847856 no 2096 0.375023796256987 3127 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_21 0849-0113 22.993 µM -0.32049715226781 0.38288844401458 no 2097 0.374295744387013 2974 1560156 SGTC_156 3474-0145 5.642 µM -0.321299655164379 0.382598971248739 no 2098 0.373991658855833 2982 2265471 SGTC_2155 5570423 76 µM -0.321681137159661 0.382461388939901 no 2099 0.373847134639728 2985 797402 SGTC_2775 cyproheptadine 69.59 µM -0.321976641756574 0.382354824761967 no 2100 0.373735195095755 3067 2913 A selective serotonin reuptake inhibitor. SGTC_45 0kpi-0036 14.9 µM -0.322174088286317 0.382283627020007 no 2101 0.373660406679718 3115 2795021 SGTC_2388 9080168 200 µM -0.322510624324792 0.382162283815082 no 2102 0.373532945173554 2952 15943073 SGTC_3169 9102970 49.47 µM -0.322715731717699 0.382088334889458 no 2103 0.373455268457815 2996 17027839 SGTC_974 1326-0144 138 µM -0.322756733211855 0.382073552825245 no 2104 0.373439741299536 3002 5411856 SGTC_1723 st034307 2.5525 µM -0.324816677469369 0.381331113091832 no 2105 0.372659910794212 3050 867466 SGTC_2221 6807166 181.081 µM -0.324988795862612 0.381269098352241 no 2106 0.372594775722223 3044 674925 SGTC_471 1-acyl-paf 4 µM -0.326963922877737 0.380557673145456 no 2107 0.371847586087388 2972 16759367 SGTC_1075 aripiprazole 15.2 µM -0.327012544066751 0.38054016525792 no 2108 0.37182919878685 2954 60795 An atypical antipschotic. YIL048W NEO1 SGTC_520 3584-0023 682 µM -0.327168002879705 0.38048418810817 no 2109 0.371770410168513 3020 1340790 SGTC_1303 1160-0052 261 µM -0.330111549173576 0.379424758170706 no 2110 0.370657838481855 3013 3562476 SGTC_2391 6285546 200 µM -0.330449548067455 0.379303164659616 no 2111 0.370530154098349 2949 846083 SGTC_2776 terbinafine 19.92 µM -0.331529143398598 0.378914865342252 no 2112 0.370122415610977 3038 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2095 5432005 200 µM -0.33152991714635 0.378914587091258 no 2113 0.370122123436406 2982 783734 SGTC_2040 5100729 123 µM -0.331590225190908 0.378892899630525 no 2114 0.370099350771023 2987 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_414 piperonyl butoxide 100 µM -0.332712233740662 0.378489482160529 no 2115 0.369675757000888 2989 5794 A potent inhibitor of cytochrome P450. SGTC_2291 7917025 104.35 µM -0.332840701716655 0.378443300019402 no 2116 0.369627266348909 2955 2964612 SGTC_470 aa-861 153 µM -0.33404020534585 0.378012181904414 no 2117 0.369174609987581 3011 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2790 5423970 71.43 µM -0.335348355149735 0.377542187990552 no 2118 0.368681160584324 3172 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1308 1187-1617 41.4 µM -0.335556689353147 0.377467354098826 no 2119 0.368602594445308 2990 2882570 SGTC_2612 dictamnine 15.46 µM -0.336925727822326 0.376975708422375 no 2120 0.36808644505099 3070 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_736 0958-0254 92.6 µM -0.337932793364811 0.376614180797115 no 2121 0.367706917135067 3105 6812352 SGTC_585 0kpi-0023 191 µM -0.338988067478166 0.376235462803646 no 2122 0.367309359654246 3133 64601 SGTC_1914 st062367 72.6 µM -0.339212932892948 0.376154778229387 no 2123 0.367224663604954 2992 978205 SGTC_2685 mycophenolic acid 18.85 µM -0.339816428163403 0.375938263206389 no 2124 0.366997387739066 3033 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1801 st050089 28.441 µM -0.340041751953723 0.375857434162315 no 2125 0.366912542913406 3003 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_433 pimozide 108 µM -0.340169276377596 0.375811690508455 no 2126 0.366864526951668 2956 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_186 3455-3465 67.277 µM -0.341336126630231 0.375393216558242 no 2127 0.366425277042318 2982 755278 SGTC_1422 4031-0024 15.5 µM -0.341557362257908 0.375313890119372 no 2128 0.366342014660573 3065 782427 SGTC_1156 4092-0367 4.88 µM -0.342321630913564 0.375039893872014 no 2129 0.366054429362114 3040 1357585 SGTC_139 0099-0334 718.624 µM -0.342896544917828 0.374833824282137 no 2130 0.365838145562393 2978 97690 SGTC_209 4077-0173 175.592 µM -0.343214511653558 0.374719869057692 no 2131 0.365718544145542 3087 15993494 SGTC_1078 idebenone 36.1 µM -0.343375529366828 0.37466216653371 no 2132 0.365657983206831 3081 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1314 1222-0010 41.1 µM -0.345108527790869 0.374041304780197 no 2133 0.365006391304231 3070 3526027 SGTC_1129 3453-1384 223 µM -0.34700291684806 0.37336299709328 no 2134 0.364294563722232 3210 1084452 SGTC_2219 9098279 200 µM -0.349080757825552 0.372619453409401 no 2135 0.363514341023254 3107 902349 SGTC_257 daunorubicin 18.5 µM -0.349264039416313 0.372553889855428 no 2136 0.363445546475014 3112 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_266 formosanin C 406 nM -0.35320939626169 0.371143453678756 no 2137 0.361965732055696 3118 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2756 carbadox 75.1 µM -0.353899101677996 0.37089706606185 no 2138 0.361707250143455 3041 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3274 9138298 49.47 µM -0.35435559021217 0.370734021014397 no 2139 0.361536205951854 2985 17015756 SGTC_3225 9130819 49.47 µM -0.354729902549465 0.370600344343445 no 2140 0.36139597345212 3156 4547121 SGTC_303 1348-1668 34.2 µM -0.355216443621807 0.370426611222383 no 2141 0.361213723373264 3065 5380509 SGTC_2127 5253358 187.912 µM -0.357547564832128 0.369594586256045 no 2142 0.360340962294819 2955 20612 SGTC_2249 haloperidol 116.36 µM -0.360485211444949 0.368546949361109 no 2143 0.359242156928458 3016 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_510 ag-490 170 µM -0.362529241163696 0.367818573687992 no 2144 0.358478288111518 3135 5328779 SGTC_1428 4049-0204 61.7 µM -0.363002191445177 0.367650108752514 no 2145 0.358301623648193 3148 X1428 SGTC_145 3737-0113 38.366 µM -0.36303413995156 0.367638729609233 no 2146 0.35828969078981 3171 6849351 SGTC_2231 micatex 6.853 µM -0.364259343567245 0.367202434916709 no 2147 0.357832178264451 3094 20737 An antifungal of unknown mechanism. SGTC_781 4335-2806 94.4 µM -0.364352724794211 0.36716918890906 no 2148 0.357797316440805 3179 845254 SGTC_2164 5685496 200 µM -0.365262103494997 0.366845479890962 no 2149 0.357457881996962 3180 759046 SGTC_2849 9019321 12.99 µM -0.366186248462038 0.366516611545292 no 2150 0.357113051390878 3164 16489627 SGTC_2343 7990716 14.84 µM -0.366312573401067 0.366471664870157 no 2151 0.357065924224328 3015 6456862 SGTC_635 k038-0028 24.7 µM -0.369948595527713 0.365178747874436 no 2152 0.355710396031323 3086 4035102 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.370264262314791 0.365066573340645 no 2153 0.355592799532299 3060 641818 YHR062C RPP1 SGTC_3042 9091578 49.47 µM -0.370383799376906 0.365024097972586 no 2154 0.355548271541913 3148 25236497 SGTC_2243 6634756 200 µM -0.370435115319171 0.365005864273644 no 2155 0.355529156771562 3279 885676 SGTC_3206 9114350 49.47 µM -0.370440024290004 0.365004120022804 no 2156 0.355527328238969 3156 17087243 SGTC_2054 5233173 129 µM -0.373641537292851 0.363867157975448 no 2157 0.354335513139154 3197 6889 SGTC_1059 3448-6867 171 µM -0.37436147716236 0.363611648332574 no 2158 0.35406769970993 3111 3934407 SGTC_197 4544-0043 41.561 µM -0.377699540485312 0.362427749993553 no 2159 0.352826904600051 3066 896523 SGTC_2478 5763493 32.33 µM -0.377896105201259 0.362358075997188 no 2160 0.35275388794341 3052 1365576 YLR208W SEC13 SGTC_688 0527-0193 473 µM -0.37806569344969 0.362297967697221 no 2161 0.352690896423251 3068 4007154 SGTC_225 nsc-122657 1.016 µM -0.378165275282515 0.362262673822472 no 2162 0.352653909828119 3168 275685 SGTC_1346 1488-2224 62.4 µM -0.37824655624316 0.362233867025675 no 2163 0.352623721558916 3179 3722427 SGTC_1968 st069590 43.6 µM -0.378905678625147 0.362000296197374 no 2164 0.352378953579552 3183 6384066 SGTC_1342 1486-1464 234 µM -0.379643800180143 0.36173879171086 no 2165 0.352104921465774 3068 3253938 SGTC_2922 7999257 32.47 µM -0.38068871726216 0.361368704946742 no 2166 0.351717120958984 3114 2988377 SGTC_2250 alverine citrate 130 µM -0.382273777387683 0.360807558995376 no 2167 0.351129151488273 3096 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_753 1322-0200 289 µM -0.38250521172534 0.360725651209246 no 2168 0.35104333194164 3203 5403907 SGTC_833 3852-0053 558 µM -0.386505817634658 0.359310794517286 no 2169 0.349561047439673 3237 3123681 SGTC_1842 st055362 61.2 µM -0.387910530009261 0.358814459181312 no 2170 0.349041122654511 3090 676032 SGTC_858 0438-0351 2.77 µM -0.388441226188048 0.358627007135399 no 2171 0.348844770276872 3114 2799119 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.388511997349989 0.358602011979048 no 2172 0.348818588699016 3318 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2652 actinonin 100 µM -0.388731330796108 0.358524551028437 no 2173 0.348737451525454 3069 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_153 4077-0274 519.67 µM -0.388882749861898 0.358471078472494 no 2174 0.348681441692058 3373 3121976 SGTC_2415 st077333 57.7 µM -0.39014680750206 0.358024793955285 no 2175 0.3482139962203 3318 2766255 SGTC_848 0368-0089 85.6 µM -0.390541967122894 0.357885319810836 no 2176 0.348067914400025 3202 762535 SGTC_716 1683-5115 658 µM -0.393044576310686 0.357002448889438 no 2177 0.347143279086861 3137 723597 SGTC_1081 sertraline 6 µM -0.393191347044885 0.356950694793334 no 2178 0.347089080093363 3198 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2481 5478948 45.16 µM -0.393627326024599 0.356796976007408 no 2179 0.346928101718622 3237 77792 SGTC_1770 st043884 66.3 µM -0.393690320002292 0.356774767322327 no 2180 0.346904844467448 3078 670149 SGTC_750 4073-0104 132 µM -0.393975396674624 0.356674268896039 no 2181 0.346799601939824 3130 22330957 SGTC_1684 st024538 14.6195 µM -0.394071750240453 0.35664030350543 no 2182 0.346764033505027 3097 6732859 SGTC_185 k048-0037 25.491 µM -0.39473643884683 0.356406026520578 no 2183 0.3465187038526 3216 6827589 SGTC_452 diindolylmethane 8 µM -0.395624224422982 0.356093201014652 no 2184 0.346191131833233 3191 3071 Inhibits expression of several cancer promoting factors. SGTC_355 1311-2252 105 µM -0.395990626449016 0.355964121596095 no 2185 0.346055971616494 3116 5338538 SGTC_831 k061-1017 217 µM -0.397987341819796 0.355260991105347 no 2186 0.34531975823667 3179 1240153 SGTC_325 2810-4341 181 µM -0.399558105942094 0.354708202550811 no 2187 0.344741009154379 3215 774970 SGTC_203 k066-0004 30.888 µM -0.401061361064534 0.354179458325229 no 2188 0.344187473833476 3200 6795412 SGTC_3170 9103054 49.47 µM -0.401364162320148 0.354072987142907 no 2189 0.344076015337105 3169 16432970 SGTC_2864 9034755 47.6 µM -0.402760105253521 0.353582292385077 no 2190 0.34356235623352 3206 4930451 SGTC_539 4859-0462 2.54 µM -0.40576477964863 0.352526930554545 no 2191 0.342457719758835 3255 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1775 st081588 35.1725 µM -0.40619982064668 0.352374220563364 no 2192 0.342297892928097 3179 1426443 YGL099W LSG1 SGTC_2370 9071495 200 µM -0.406992858152387 0.352095906312497 no 2193 0.342006616812016 3194 21791103 SGTC_3167 9103034 49.47 µM -0.408468587687969 0.351578214167866 no 2194 0.341464843881198 3184 5127859 SGTC_448 monastrol 171 µM -0.409085759472773 0.351361789244465 no 2195 0.341238363240584 3165 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.409169254533313 0.351332513555404 no 2196 0.341207727838136 3274 688798 SGTC_2455 5377712 9.75 µM -0.410016805631041 0.351035388528212 no 2197 0.340896809796267 3183 2243908 SGTC_447 ml7 120 µM -0.411472329341938 0.350525339762592 no 2198 0.340363113524779 3212 4216 Selective myosin light chain kinase inhibitor. SGTC_2079 5212404 121 µM -0.411842464297438 0.350395678939906 no 2199 0.340227447218601 3268 758462 SGTC_371 0195-0006 7.36 µM -0.413681403095911 0.349751744722943 no 2200 0.339553724191653 3085 3928593 SGTC_2175 5807670 165.306 µM -0.413958376424122 0.349654795410361 no 2201 0.33945229517332 3242 241186 SGTC_3063 1327-0034 4 µM -0.414458376265857 0.349479804682607 no 2202 0.339269222178787 3217 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_659 k018-0002 107 µM -0.419212770743027 0.347817456925065 no 2203 0.337530319822632 3260 6797879 YHR007C ERG11 SGTC_1390 3413-2614 145 µM -0.419800410230453 0.347612194228439 no 2204 0.337315632596136 3187 3421432 SGTC_397 arbidol 50 µM -0.419982713231783 0.347548524796008 no 2205 0.337249041082331 3280 131410 A RNA synthesis inhibitor. SGTC_1828 st055811 49 µM -0.421267968963986 0.347099770585896 no 2206 0.336779708540188 3251 5877589 SGTC_1189 1431-2119 7.28 µM -0.421411219622428 0.347049767083113 no 2207 0.336727413899607 3222 3107275 SGTC_1175 0741-0056 27.6 µM -0.421589282262813 0.346987615718418 no 2208 0.336662415305821 3325 765927 SGTC_1132 3456-3614 2.5 µM -0.424654820803342 0.345918260278086 no 2209 0.335544161607488 3360 3125502 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.427853473104001 0.344803779402402 no 2210 0.334378901437344 3235 4213774 SGTC_5 0352-0601 109.883 µM -0.429192628471359 0.344337587144411 no 2211 0.333891523548515 3197 762456 SGTC_4 0960-0234 25.671 µM -0.429279223673963 0.344307449397783 no 2212 0.333860017355087 3240 6821112 SGTC_3081 9117243 49.47 µM -0.429286932396209 0.344304766577472 no 2213 0.333857212724216 3306 45595589 SGTC_300 r073-0011 5.04 µM -0.429406496912144 0.344263156260193 no 2214 0.333813713275118 3263 2735780 SGTC_601 0986-0029 62.9 µM -0.430850900589988 0.343760630319378 no 2215 0.333288393126891 3183 24747981 SGTC_326 k292-0812 17.5 µM -0.431241889565561 0.343624647827743 no 2216 0.333146249169519 3239 3579357 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.431761742703385 0.343443878862062 no 2217 0.332957293791246 3185 3256 An antibiotic and ribosome inhibitor. SGTC_2677 mitomycin C 100 µM -0.43220787096943 0.343288774853426 no 2218 0.332795169620765 3187 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1993 st073995 70.8 µM -0.432480321265231 0.343194065896086 no 2219 0.332696175847456 3176 3098394 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.435364053808136 0.342192229848663 no 2220 0.331649098892105 3395 6710655 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.43567784172878 0.342083283769147 no 2221 0.331535242314943 3205 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2053 5265679 138 µM -0.436176047947966 0.341910335301439 no 2222 0.331354502340357 3139 764595 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.436856667239129 0.341674117148953 no 2223 0.331107649766376 3177 390807 SGTC_1490 4089-0339 670 nM -0.437588167611548 0.341420309138137 no 2224 0.330842425048882 3276 742542 SGTC_3275 9138069 49.47 µM -0.437891390854081 0.341315121063633 no 2225 0.330732508358927 3259 17617007 SGTC_603 3794-0023 45.9 µM -0.438551240690799 0.341086261914382 no 2226 0.330493367013556 3257 3802260 SGTC_410 α-linolenic acid 100 µM -0.439303612749683 0.340825384123975 no 2227 0.330220778395383 3296 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2103 5378138 10 µM -0.439407706194776 0.340789296711173 no 2228 0.330183071847061 3294 244142 SGTC_366 0181-0206 4.31 µM -0.439450808266313 0.34077435438846 no 2229 0.330167459165726 3370 274874 SGTC_2145 5634607 200 µM -0.44255665013154 0.339698301873882 no 2230 0.329043223036032 3170 308662 SGTC_541 4513-1321 94 µM -0.442804719031583 0.33961241189195 no 2231 0.328953494853987 3192 747515 SGTC_164 4100-3994 89.624 µM -0.446674271866912 0.338273720316478 no 2232 0.327555130393987 3336 4615967 SGTC_1000 4048-0884 8.67 µM -0.448920968269671 0.337497399926848 no 2233 0.326744334706942 3294 13040088 SGTC_505 gw-5074 63.9 µM -0.448965096445733 0.337482158847636 no 2234 0.326728417749686 3301 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1229 0139-0193 12.2 µM -0.449170116992632 0.3374113519312 no 2235 0.326654471327195 3328 3090752 SGTC_1120 ficusin 1.78878 µM -0.452804049149483 0.336157276412071 no 2236 0.325344923831079 3307 6199 A DNA cross-linker. SGTC_311 1315-0136 58 µM -0.453396868500258 0.335952865978986 no 2237 0.32513149548544 3358 6759207 SGTC_2798 7813637 45.45 µM -0.45420050025895 0.335675842643392 no 2238 0.324842261506825 3319 956368 SGTC_843 0310-0051 143 µM -0.454430949572857 0.335596419941736 no 2239 0.324759340285363 3240 2065037 SGTC_347 4534-1311 26.2 µM -0.455855245010584 0.335105709833598 no 2240 0.324247037247366 3236 2862016 SGTC_1956 st077085 54 µM -0.456040469011463 0.335041915573108 no 2241 0.324180438674446 3227 24208685 SGTC_2957 9076800 11.52 µM -0.457955963883223 0.334382466284355 no 2242 0.323492039443049 3217 16459615 SGTC_940 3232-1287 54.8 µM -0.458451347794364 0.334212003025122 no 2243 0.323314104284942 3311 1585493 YIL048W NEO1 SGTC_2051 5263410 176 µM -0.460337410492001 0.3335633156649 no 2244 0.322637026299865 3343 227584 SGTC_3134 9127454 49.47 µM -0.461072546237727 0.333310609624572 no 2245 0.322373278832923 3351 24262820 SGTC_532 1548-0774 215 µM -0.461288922743781 0.333236243683907 no 2246 0.322295665626064 3425 5932993 SGTC_3114 9122766 49.47 µM -0.462876455224564 0.332690828973715 no 2247 0.32172646249366 3261 17176985 SGTC_2825 7998094 58.44 µM -0.463350220362011 0.332528130128693 no 2248 0.321556676940982 3233 2987815 SGTC_138 0850-0259 40.9225 µM -0.463953859428939 0.33232087611407 no 2249 0.321340401822081 3315 6813004 SGTC_1310 1188-0297 994 nM -0.464095732973787 0.332272172553437 no 2250 0.321289579376864 3224 1588352 SGTC_2258 7960471 200 µM -0.468155132670918 0.330879829931114 no 2251 0.319836827542531 3258 2974708 SGTC_3008 9078912 71.4286 µM -0.469134955150873 0.33054410768245 no 2252 0.319486587498553 3239 16648731 SGTC_1482 3346-2049 8.48 µM -0.469661390329903 0.33036378842207 no 2253 0.319298478355459 3314 3826804 SGTC_1208 2323-2347 50.3 µM -0.472499555768558 0.329392314136765 no 2254 0.318285129372095 3341 5412760 SGTC_778 3456-2434 196 µM -0.472581691876406 0.329364216906899 no 2255 0.31825582338394 3336 5539063 SGTC_236 1509-0011 5.31 µM -0.473198028305276 0.329153410466296 no 2256 0.318035952164269 3396 3107280 SGTC_2189 6047310 154.431 µM -0.473306096457871 0.329116453354348 no 2257 0.317997406648152 3221 711535 SGTC_63 0099-0242 26.702 µM -0.476563810185445 0.328003166850511 no 2258 0.316836379416034 3354 3898502 YLR359W ADE13 SGTC_2207 7258803 200 µM -0.477074919232273 0.327828639445308 no 2259 0.316654386807933 3323 3666799 SGTC_445 e6 berbamine 66 µM -0.4772162476173 0.327780386952472 no 2260 0.316604071283485 3318 6610268 A calcium/calmodulin antagonist. SGTC_2475 5812728 15.03 µM -0.478258218995331 0.327424724729358 no 2261 0.316233214947351 3233 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3260 9137109 49.47 µM -0.478387928681317 0.327380461111684 no 2262 0.316187061864784 3262 17478346 SGTC_208 k072-0098 12.366 µM -0.478798237527225 0.327240458608248 no 2263 0.316041085320879 3289 5948901 SGTC_2267 7931562 200 µM -0.478989327395749 0.327175264651201 no 2264 0.31597311061447 3169 934880 SGTC_2766 oltipraz 83.91 µM -0.479768995067784 0.326909320799094 no 2265 0.31569583083668 3346 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2131 toluylene red 5.2905 µM -0.480740304361808 0.326578131143507 no 2266 0.315350541017053 3230 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3129 9127257 49.47 µM -0.483018357511938 0.325801914277787 no 2267 0.314541350867909 3199 837894 SGTC_2046 4110841 106 µM -0.483232394522262 0.325729022686593 no 2268 0.314465368193472 3376 44119630 YMR134W ERG29 SGTC_2858 9025781 8.96 µM -0.483519153423937 0.325631375660098 no 2269 0.314363581722864 3347 4894980 YPL153C RAD53 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.485088613732021 0.325097155739885 no 2270 0.313806744282471 3236 15053 SGTC_1274 0865-0114 173 µM -0.485861931537171 0.324834062444909 no 2271 0.313532530392054 3291 870624 SGTC_1012 4112-3522 18 µM -0.48771257815777 0.324204801988016 no 2272 0.312876720581602 3376 3112398 SGTC_2605 digitonin 300 nM -0.488867815528712 0.323812250202383 no 2273 0.312467641339156 3440 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2865 9030313 51.95 µM -0.491356859785019 0.322967134568554 no 2274 0.311587035343528 3209 42562754 SGTC_3091 9116372 49.47 µM -0.491838165892527 0.322803819921209 no 2275 0.311416876756343 3402 17169793 SGTC_172 1112-0046 2.638 µM -0.492251686854083 0.322663533115178 no 2276 0.31127071476114 3229 2802135 YIL048W NEO1 SGTC_3304 9125678 46.087 µM -0.492612937380547 0.322540999685179 no 2277 0.31114305247746 3249 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1715 st032160 10.2275 µM -0.494956379585336 0.321746590427729 no 2278 0.310315455904912 3331 5289825 SGTC_1248 0469-0687 58.6 µM -0.495104519127349 0.3216963995635 no 2279 0.310263172000211 3351 4017482 SGTC_763 3453-1109 128 µM -0.495190690618899 0.321667205468275 no 2280 0.310232760668587 3408 1560353 SGTC_1261 0712-0010 12.7 µM -0.495616725800786 0.321522884916919 no 2281 0.31008242494153 3436 2840123 SGTC_1714 st033236 13.627 µM -0.4968017998077 0.321121579662918 no 2282 0.309664412953692 3437 2916566 SGTC_1178 0988-0033 191 µM -0.497416583166578 0.320913475914568 no 2283 0.309447656882676 3368 5392207 SGTC_667 1498-1044 59 µM -0.498274405683079 0.320623197585874 no 2284 0.309145322510828 3303 6739982 SGTC_2833 9001315 45.46 µM -0.499134026551738 0.320332420718117 no 2285 0.308842483926757 3214 2989378 SGTC_1735 st034310 56.75 µM -0.499282827692528 0.320282098174174 no 2286 0.308790075482503 3404 871153 SGTC_1811 st050069 61.5 µM -0.499915716725311 0.320068100548635 no 2287 0.308567212569844 3376 3877702 SGTC_1469 k284-2957 126 µM -0.500033883446841 0.320028151676795 no 2288 0.308525609640255 3319 23884841 SGTC_1353 1498-1206 8.11 µM -0.500600310280588 0.319836687547805 no 2289 0.308326222019069 3403 6756808 SGTC_144 4161-2749 112.381 µM -0.500859513090328 0.319749087573268 no 2290 0.308234999020103 3290 797501 YMR168C CEP3 SGTC_363 0455-0021 3.06 µM -0.502892939666265 0.319062221463602 no 2291 0.307519772658629 3328 4597466 SGTC_752 1896-0090 130 µM -0.503641766471852 0.318809433386359 no 2292 0.307256568458411 3363 772567 SGTC_47 0149-0135 24.25 µM -0.504454784775234 0.318535071039795 no 2293 0.306970914044605 3276 5239155 SGTC_1283 0922-0125 16.4 µM -0.504943776198774 0.318370103172901 no 2294 0.306799163048975 3338 3360884 SGTC_536 3852-0578 10.6 µM -0.504947355973932 0.318368895620096 no 2295 0.306797905862274 3408 2869208 SGTC_600 1495-0418 41.6 µM -0.505052853658476 0.318333309328424 no 2296 0.306760856989799 3304 5377768 SGTC_3079 9117512 49.47 µM -0.505220598610873 0.318276729350775 no 2297 0.306701952071174 3375 7185044 SGTC_1404 3909-7820 48.3 µM -0.507281159833237 0.317582053115882 no 2298 0.305978777952224 3388 23741373 SGTC_1646 st011709 75.6 µM -0.507555408370237 0.317489644153177 no 2299 0.305882584665416 3386 5757843 SGTC_3222 9128301 49.47 µM -0.509015203404798 0.316997952819614 no 2300 0.305370783734611 3268 4911358 SGTC_867 0518-0118 155 µM -0.509472983000158 0.316843828982449 no 2301 0.305210365475703 3394 6848158 SGTC_1871 st057448 67.3 µM -0.509809835511334 0.316730438802038 no 2302 0.305092347203396 3494 691747 SGTC_1215 3852-0577 11.2 µM -0.510651860585537 0.316447074426402 no 2303 0.304797427396329 3420 2884876 SGTC_982 1491-0518 27.5 µM -0.511038693506941 0.316316930711417 no 2304 0.304661981416793 3282 3091256 SGTC_1996 st072960 66.8 µM -0.51107617533771 0.316304321760876 no 2305 0.304648858921981 3422 1719405 SGTC_3065 9113888 49.47 µM -0.511159213511055 0.31627638834124 no 2306 0.304619787918318 3470 16648368 SGTC_2012 4023501 200 µM -0.511235505960339 0.316250725056742 no 2307 0.30459307962659 3317 3477460 SGTC_2961 9083290 32.55 µM -0.511802696026726 0.316059961192081 no 2308 0.304394551651389 3376 17741490 SGTC_3149 9097855 49.47 µM -0.512420859971066 0.315852108968174 no 2309 0.304178247414055 3386 25236625 YMR079W SEC14 SGTC_1925 st057770 10.1 µM -0.513352409235393 0.31553899364362 no 2310 0.303852414679369 3280 5989122 SGTC_2486 5283202 22.39 µM -0.513502036036188 0.31548871293802 no 2311 0.303800093465443 3310 1377751 SGTC_3165 9101544 49.47 µM -0.514796988280277 0.315053698985106 no 2312 0.303347445071737 3390 5002184 SGTC_3316 9136639 10.545 µM -0.515484602223025 0.314822812666359 no 2313 0.303107213345485 3390 4903665 SGTC_2511 berberine 10.47 µM -0.516121773996139 0.314608928359074 no 2314 0.302884680598399 3308 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1358 1509-0022 2.48 µM -0.516854541366862 0.314363031640641 no 2315 0.302628851476917 3375 3258434 SGTC_200 k038-0079 37.545 µM -0.517478112028614 0.314153843204203 no 2316 0.302411222202372 3299 3436683 SGTC_1985 st071382 65.5 µM -0.518422724100135 0.313837069133883 no 2317 0.302081681636861 3398 6123237 SGTC_1250 0485-0349 40.2 µM -0.518751247506402 0.313726931498123 no 2318 0.301967109651344 3294 6842794 YDL195W SEC31 SGTC_583 1488-1091 88.9 µM -0.519545083945718 0.313460865963352 no 2319 0.301690341133038 3422 4303273 SGTC_2075 5212009 200 µM -0.520227103559255 0.313232354909866 no 2320 0.301452648330645 3390 780898 SGTC_1965 Pectolinarigenin 58.4 µM -0.520385331091607 0.313179350929585 no 2321 0.30139751600252 3320 5320438 An anti-inflammatory. SGTC_894 0960-0238 55.9 µM -0.520901171490691 0.313006578515641 no 2322 0.301217809644459 3418 6741907 YDL195W SEC31 SGTC_2294 7971431 200 µM -0.524565361205713 0.311780500682703 no 2323 0.2999426858725 3369 5741572 SGTC_2638 epoxomicin 18 µM -0.525686331446947 0.311405827322771 no 2324 0.299553081136508 3388 9915668 A protesome inhibitor. SGTC_2540 epiandrosterone 100 µM -0.525833345541163 0.311356703771482 no 2325 0.299502001892879 3461 441302 A steroid. SGTC_3120 9124077 49.47 µM -0.525977444905721 0.31130855741267 no 2326 0.299451939188011 3415 18774327 YGL155W CDC43 SGTC_1898 st060199 18.6 µM -0.526851952133938 0.311016437045073 no 2327 0.29914820109731 3381 688866 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.528628037234198 0.310423520128413 no 2328 0.29853175341277 3294 2724 A muscle relaxant with antifungal properties. SGTC_2840 9008771 71.43 µM -0.531169721276451 0.309575877051077 no 2329 0.297650586548582 3351 2992978 SGTC_2997 9067075 71.4286 µM -0.531314287632488 0.309527695031013 no 2330 0.297600503076955 3380 27209819 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.531358870065783 0.309512836966651 no 2331 0.297585058744636 3440 5282362 SGTC_1392 3455-1037 33.9 µM -0.532320741949428 0.309192348123534 no 2332 0.297251934371139 3466 981132 SGTC_1161 k007-0610 110 µM -0.533382250513813 0.308838829515921 no 2333 0.296884500843926 3479 5843850 SGTC_3302 9125395 16.351 µM -0.533796907379795 0.308700782683019 no 2334 0.296741026835686 3318 17599668 SGTC_923 1900-2434 73.3 µM -0.534279745578171 0.308540071101625 no 2335 0.296574001652712 3402 5910570 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.534312045806803 0.308529321353369 no 2336 0.296562829774763 3346 4330530 SGTC_2437 5741531 144.16 µM -0.535146282161127 0.308251738378564 no 2337 0.296274354157345 3478 2262990 SGTC_3177 9107506 49.47 µM -0.53592546976144 0.307992571266377 no 2338 0.296005030471218 3400 8897194 SGTC_174 3553-0389 74.3 µM -0.536101732026051 0.307933957602291 no 2339 0.295944121577542 3442 738071 SGTC_689 0833-0039 98 µM -0.541327728735326 0.306198353603094 no 2340 0.294140855666071 3397 5374726 SGTC_550 4123-0385 25.7 µM -0.543066385068268 0.305621889330246 no 2341 0.293542048017843 3356 5731123 SGTC_3284 9108171 64.8615 µM -0.545127887654284 0.304939006872315 no 2342 0.292832781826803 3381 8687505 SGTC_1926 methyl fluorone black 53.6 µM -0.545433775606504 0.304837737821561 no 2343 0.292727607972407 3329 72721 Reacts with homocysteine. SGTC_2869 9037858 32.47 µM -0.545894259679099 0.304685315469523 no 2344 0.292569312222463 3410 27187042 SGTC_1889 st059080 5.18 µM -0.547067139943473 0.304297239871915 no 2345 0.292166303334583 3482 176925 Isolated from Daphnopsis sellowiana. SGTC_1073 triclabendazole 3.09 µM -0.547641542541286 0.304107265310922 no 2346 0.291969029337585 3447 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2091 4-phenylthiadiazole 200 µM -0.548987852706391 0.303662201809793 no 2347 0.291506893056392 3369 270010 SGTC_648 0375-0473 33.3 µM -0.550307742344265 0.30322615488504 no 2348 0.291054157375233 3406 1713139 SGTC_3108 9121785 49.47 µM -0.551008479276257 0.302994768914501 no 2349 0.290813930974202 3423 17140271 SGTC_2206 7254556 146.969 µM -0.551607983325768 0.302796873160721 no 2350 0.290608482801189 3397 4398905 SGTC_609 0986-0026 86.3 µM -0.553533469413006 0.302161663786169 no 2351 0.289949084414921 3421 2848610 SGTC_3053 9095903 49.47 µM -0.553806116548116 0.302071767063866 no 2352 0.289855770918034 3467 17174018 SGTC_2367 9070478 135.38 µM -0.554050470511844 0.30199120932137 no 2353 0.289772152731978 3431 572802 SGTC_1943 st076331 65.2 µM -0.554689051074307 0.301780729935845 no 2354 0.289553683239717 3493 24208415 SGTC_2880 9042983 58.44 µM -0.558492523632507 0.300528454630591 no 2355 0.288254054187856 3474 6464714 SGTC_1103 duloxetine 36.1 µM -0.559872069252466 0.300074826424624 no 2356 0.28778335065449 3503 60835 A selective serotonin reuptake inhibitor. SGTC_1939 st074455 53.6 µM -0.561939069238116 0.299395726834745 no 2357 0.287078766787666 3514 1644229 SGTC_1406 3909-7906 11.9 µM -0.563071105867947 0.299024099067109 no 2358 0.286693232913342 3473 X1406 SGTC_2909 7941780 10.49 µM -0.563836425881597 0.298772976665071 no 2359 0.28643272963606 3502 1243215 SGTC_2738 aclarubicin 5.55 µM -0.564455841250346 0.298569799772867 no 2360 0.286221972363257 3364 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2447 5741742 33.78 µM -0.56499363306342 0.298393447531249 no 2361 0.28603904741225 3458 1776504 SGTC_2460 5552655 174.22 µM -0.566537589581352 0.297887418220651 no 2362 0.285514193687623 3463 5401989 SGTC_1928 4'-methoxychalcone 40.3 µM -0.566904886629792 0.297767094830575 no 2363 0.285389401993642 3542 641818 SGTC_1750 st081859 2.357 µM -0.567216589810379 0.297665000912654 no 2364 0.285283519077984 3506 5291695 SGTC_1044 1222-0021 1.78 µM -0.567407971497385 0.297602324494381 no 2365 0.285218517623317 3428 4306703 SGTC_623 k072-0108 16.9 µM -0.567714126570857 0.297502072969607 no 2366 0.285114548866208 3434 5382803 SGTC_2782 7736369 71.43 µM -0.568980633579223 0.297087514853808 no 2367 0.284684641373458 3425 2950836 YOL077C BRX1 SGTC_490 phenamil 164 µM -0.570662271627408 0.296537482993894 no 2368 0.284114299037841 3412 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2113 5491891 107.031 µM -0.571178888479938 0.29636860117008 no 2369 0.283939193685341 3438 789979 SGTC_121 0557-0495 61.343 µM -0.571616069971646 0.296225721186209 no 2370 0.283791053008202 3471 3104427 SGTC_2854 9024559 71.43 µM -0.572189355444202 0.29603840749386 no 2371 0.283596849057187 3433 3163529 SGTC_2021 4019055 173 µM -0.572285650936843 0.296006949507501 no 2372 0.28356423461837 3527 44827708 YER133W GLC7 SGTC_877 0771-0151 33.1 µM -0.573741256406843 0.295531616699521 no 2373 0.28307145284677 3422 6166523 SGTC_52 0329-0193 875 nM -0.574392594752923 0.295319033722702 no 2374 0.282851081452794 3551 3739292 SGTC_956 1185-0240 191 µM -0.574489028004284 0.295287565942715 no 2375 0.282818461589154 3431 1416193 SGTC_1658 st012944 20 µM -0.574888798671193 0.295157130561367 no 2376 0.282683252980002 3457 24207260 SGTC_373 0844-0104 25.9 µM -0.575349352976262 0.295006895861658 no 2377 0.282527524923229 3489 5375804 SGTC_577 r071-0003 38.6 µM -0.57611103659378 0.294758508887592 no 2378 0.282270066024339 3466 4568517 YMR134W ERG29 SGTC_703 3875-0075 71.8 µM -0.576500483933485 0.294631546383097 no 2379 0.282138471428321 3483 2850814 SGTC_3166 9102297 49.47 µM -0.577480921863466 0.294312028642873 no 2380 0.281807311427868 3438 25237072 SGTC_878 0828-0289 13.7 µM -0.578461220995875 0.293992716219354 no 2381 0.281476385713378 3496 745350 YLR208W SEC13 SGTC_1946 st076057 65.1 µM -0.580002290554622 0.29349106836165 no 2382 0.280956536569998 3411 953009 SGTC_328 k915-0120 63.5 µM -0.580073934006209 0.29346775668361 no 2383 0.28093238036902 3485 6624543 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.580826686420719 0.293222874481007 no 2384 0.280678633664091 3390 688803 SGTC_677 0929-0063 136 µM -0.580890228480991 0.293202207585697 no 2385 0.280657219228692 3455 1539583 SGTC_161 4065-0411 162.148 µM -0.580892454517258 0.293201483585243 no 2386 0.280656469042136 3441 1906281 YLR208W SEC13 SGTC_1431 4049-0260 9.09 µM -0.581472714115325 0.293012787076743 no 2387 0.280460951433401 3479 3854841 SGTC_629 3448-6466 76.7 µM -0.581847668566809 0.292890884391316 no 2388 0.280334646166537 3500 573744 SGTC_626 0214-0009 33 µM -0.582279358723829 0.292750565330772 no 2389 0.28018926331816 3516 3437874 SGTC_2394 5221648 200 µM -0.583123701942579 0.292476205414628 no 2390 0.279905014498637 3511 788586 SGTC_2404 5161160 200 µM -0.583548803496276 0.292338118652393 no 2391 0.279761956667763 3471 2831543 SGTC_1808 st050063 61.5 µM -0.583924124745679 0.292216227352738 no 2392 0.279635680709443 3510 4011993 SGTC_3176 9106582 49.47 µM -0.584639698143995 0.291983899516235 no 2393 0.279395004391011 3424 17018027 SGTC_773 4358-1457 44.6 µM -0.584705772028679 0.291962451404127 no 2394 0.279372786142774 3519 1186886 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.585475404480758 0.291712676605322 no 2395 0.279114049940592 3413 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_777 1315-0167 517 µM -0.586036484059709 0.291530647879137 no 2396 0.278925498815176 3464 4221767 SGTC_2780 5215298 71.43 µM -0.588057375176448 0.290875457925502 no 2397 0.27824689115092 3517 2834131 SGTC_644 1498-1197 63.3 µM -0.588937630552926 0.290590287049224 no 2398 0.277951556578888 3527 6741615 SGTC_2707 st078556 66.6 µM -0.590198276054461 0.290182111506329 no 2399 0.27752886389077 3457 17250899 SGTC_2116 5511452 16.8835 µM -0.590682053777758 0.290025543874145 no 2400 0.277366737338338 3503 870744 SGTC_2197 6588183 93.1375 µM -0.59105531855664 0.289904769222413 no 2401 0.27724167821757 3480 884136 SGTC_983 1491-0821 12.2 µM -0.59170390504753 0.289694966784733 no 2402 0.27702444057132 3494 46495113 SGTC_553 k007-0256 45.7 µM -0.593138576361987 0.289231137758553 no 2403 0.276544207764411 3489 6287000 SGTC_287 k060-0039 29.6 µM -0.593753189798417 0.289032540189364 no 2404 0.276338600891813 3533 5861974 SGTC_2981 9013952 38.96 µM -0.593819461518355 0.289011129906604 no 2405 0.276316435467183 3443 2996344 SGTC_1193 1488-0126 41.5 µM -0.597479090670396 0.287829980074955 no 2406 0.275093781481134 3522 1384710 SGTC_2480 5767542 37.17 µM -0.599970298639436 0.287027246153783 no 2407 0.27426301506234 3508 2867358 SGTC_795 0685-0265 78 µM -0.600440329545454 0.286875908591518 no 2408 0.274106408497868 3589 302754 SGTC_3158 9100007 49.47 µM -0.601333296918864 0.286588500832464 no 2409 0.273809008208005 3462 19297233 SGTC_776 4476-4378 112 µM -0.602226327037334 0.286301209540621 no 2410 0.273511746690363 3514 2892008 SGTC_1361 1608-0041 5.61 µM -0.60361813528293 0.28585373218008 no 2411 0.273048776400246 3517 X1361 SGTC_255 tunicamycin 200.472 nM -0.604437842662809 0.285590345473204 no 2412 0.272776291291434 3478 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3022 9087993 49.47 µM -0.604539556931633 0.285557670908131 no 2413 0.272742489095504 3539 17173644 SGTC_3314 9135860 59.4275 µM -0.605747434908472 0.285169789781474 no 2414 0.272341239982532 3536 25252478 SGTC_1866 st057638 64 µM -0.606502699007721 0.284927382438536 no 2415 0.272090495319705 3482 688802 SGTC_1653 st012112 65 µM -0.607108927468099 0.284732880269928 no 2416 0.27188931296744 3548 720429 SGTC_351 caspofungin 25 nM -0.607749764873052 0.284527343104441 no 2417 0.271676725818484 3550 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_732 3970-1727 52.7 µM -0.611168723805173 0.283431972264976 no 2418 0.270543943342355 3541 1275699 SGTC_3099 9120367 49.47 µM -0.612603048667821 0.282973043932162 no 2419 0.270069420962165 3562 24824940 SGTC_1693 xanthone 101.9 µM -0.612818046102141 0.282904283848192 no 2420 0.269998328561211 3525 7020 An insecticide. SGTC_1649 st011737 51.3 µM -0.612944704372925 0.282863779988935 no 2421 0.269956451326502 3500 1761035 SGTC_3015 9080845 49.47 µM -0.613230400333997 0.282772427931715 no 2422 0.269862003133363 3553 5296973 SGTC_423 5-fluorouracil 457 µM -0.613980024954696 0.282532800835328 no 2423 0.269614263495043 3506 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1010 4112-3296 15.2 µM -0.614025450139908 0.282518283231899 no 2424 0.269599254818389 3592 704384 SGTC_1640 st009078 66.4 µM -0.615966601974399 0.281898238708946 no 2425 0.268958281316006 3553 690618 SGTC_1145 3546-0597 10.2 µM -0.616938950386733 0.281587896932435 no 2426 0.268637497117299 3478 875334 SGTC_2023 5144124 124 µM -0.618697308521937 0.281027105358725 no 2427 0.268057891708991 3517 2830192 SGTC_2797 7859098 81.82 µM -0.61930790698035 0.280832494051572 no 2428 0.267856768258998 3528 972681 SGTC_170 4197-0004 226 µM -0.619555064596257 0.280753737952741 no 2429 0.267775379266495 3551 218692 SGTC_79 0052-0007 94.094 µM -0.621215552277152 0.280224905203544 no 2430 0.267228903997834 3606 2801472 SGTC_1575 cyproterone acetate 48 µM -0.621926728736771 0.279998557147088 no 2431 0.266995024340859 3475 9880 An androgen receptor antagonist and liver toxin. SGTC_2026 5148700 152 µM -0.622385053062895 0.279852732006738 no 2432 0.266844353204882 3524 79838 SGTC_3048 9093155 49.47 µM -0.622795967746448 0.27972202252768 no 2433 0.266709304214947 3545 25236002 SGTC_3000 9075062 71.4286 µM -0.624372971342651 0.279220662392902 no 2434 0.266191335691168 3504 17057871 SGTC_453 enantio-paf c16 10 µM -0.625023175298049 0.279014077137233 no 2435 0.265977923875526 3563 13871343 A lipid and platelet activating factor SGTC_3010 9080089 71.4286 µM -0.625539517303438 0.278850075979496 no 2436 0.265808510383318 3570 17027233 SGTC_3111 9122088 49.47 µM -0.628442809873182 0.277928803173261 no 2437 0.264856950105679 3478 16876704 SGTC_1423 4048-0112 5.59 µM -0.628480337729025 0.277916904565759 no 2438 0.264844661616666 3563 X1423 SGTC_1074 carmofur 3.8 µM -0.628921016580093 0.277777201234201 no 2439 0.264700383100372 3607 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1941 st076221 61.8 µM -0.62939732149686 0.277626242354526 no 2440 0.264544485550225 3559 2828568 SGTC_1397 3532-0190 20.1 µM -0.629586188811108 0.277566394323159 no 2441 0.26448268104521 3486 5322280 SGTC_857 0438-0306 1.35 µM -0.629890186618537 0.277470077131019 no 2442 0.264383216936669 3596 4686136 SGTC_1295 1013-0063 9.78 µM -0.631137997718467 0.277074897944627 no 2443 0.263975149032339 3568 6826038 SGTC_2464 5717415 7.67 µM -0.633083180127063 0.276459412621923 no 2444 0.263339662747435 3470 5285744 SGTC_888 0916-0002 6.97 µM -0.633330588117496 0.276381177054058 no 2445 0.26325889120198 3613 2802138 YIL048W NEO1 SGTC_1847 st056231 15 µM -0.633577105156615 0.276303234026035 no 2446 0.263178423113239 3587 5393180 SGTC_1146 3579-1023 7 µM -0.635375514561061 0.275734944791101 no 2447 0.26259176678234 3588 X1146 SGTC_1220 1838-0075 193 µM -0.635614146692255 0.275659581311427 no 2448 0.262513973289226 3531 5529645 SGTC_1547 harmine 94.2 µM -0.636001744089102 0.275537194031437 no 2449 0.262387642629222 3617 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1297 1068-0111 14.1 µM -0.636024524121039 0.275530001867965 no 2450 0.262380218840967 3542 767057 SGTC_2927 9011802 47.9 µM -0.637695846976949 0.275002580050337 no 2451 0.261835844753792 3556 43912568 SGTC_1512 0259-0544 12.2 µM -0.638848846089367 0.274639016570259 no 2452 0.261460634183085 3578 18476 SGTC_3239 9133757 49.47 µM -0.640037898155079 0.274264333344498 no 2453 0.26107398058217 3579 17036923 SGTC_482 fipronil 114 µM -0.643528395755844 0.273165899821246 no 2454 0.259940647785476 3607 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2303 7774051 200 µM -0.643595355078327 0.273144849551104 no 2455 0.259918931535419 3586 2953184 SGTC_2067 5224629 34.075 µM -0.644867241287259 0.272745154310835 no 2456 0.259506611131677 3584 2835000 SGTC_3141 9094609 49.47 µM -0.645128134937765 0.272663203338095 no 2457 0.259422076329364 3525 25236309 YDL196W YDL196W SGTC_1594 piperine 70.1 µM -0.646535949987453 0.272221196552891 no 2458 0.258966161471689 3584 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2979 9012552 45.46 µM -0.647183944475276 0.272017867723461 no 2459 0.258756450606239 3662 17100905 SGTC_1600 coumarin 106 71.1 µM -0.647469920044251 0.27192815784192 no 2460 0.258663928114378 3632 100336 A hepatotoxic, DNA x-linker. SGTC_3152 9099253 49.47 µM -0.647532621020969 0.271908490656288 no 2461 0.258643644577938 3610 25236131 SGTC_2875 9039966 71.43 µM -0.648451584267953 0.27162032403166 no 2462 0.258346457838662 3597 6463691 SGTC_883 0850-0245 24.6 µM -0.648586671776651 0.271577976388454 no 2463 0.258302786338564 3624 6823229 YPR165W RHO1 SGTC_2227 7312221 64.1025 µM -0.649265986730752 0.271365072519736 no 2464 0.258083233344277 3609 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2597 laccaic acid a 100 µM -0.652478957240956 0.270359224848826 no 2465 0.257046121649155 3562 5491415 A textile dye. SGTC_2482 5981709 142.65 µM -0.652972182153564 0.270204981769473 no 2466 0.256887106192605 3582 877755 SGTC_1905 st060207 84.5 µM -0.653868169867138 0.26992489787999 no 2467 0.256598371229465 3542 1948547 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.653899754545457 0.269915027227666 no 2468 0.256588196048785 3599 97141 SGTC_2586 curcumin 80 µM -0.654878266603882 0.269609318098979 no 2469 0.256273067052965 3607 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2663 amphotericin b 100 µM -0.654975331223345 0.269579002393648 no 2470 0.256241818475709 3587 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2319 6033012 152.6 µM -0.655881924757984 0.2692959330903 no 2471 0.255950049499688 3556 847246 SGTC_733 4069-0007 56.1 µM -0.655940173267492 0.26927775102422 no 2472 0.255931309311499 3640 5717425 YNL287W SEC21 SGTC_319 1348-1596 45.5 µM -0.656133404606483 0.269217438954934 no 2473 0.255869146467965 3660 5380505 SGTC_2978 9011784 42.97 µM -0.656358851262242 0.269147080289589 no 2474 0.255796629864677 3654 2994934 SGTC_2270 7924575 90.91 µM -0.657479187865793 0.26879757621115 no 2475 0.255436424402846 3601 1262135 SGTC_560 2332-1943 155 µM -0.657957766237066 0.26864834676603 no 2476 0.255282634924009 3601 21177716 SGTC_2471 5466956 24.79 µM -0.659551690194322 0.268151632682293 no 2477 0.25477078233909 3566 724419 SGTC_258 haloperidol 50.781 µM -0.660022641876497 0.268004958645352 no 2478 0.254619649767002 3584 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2456 5770359 74.46 µM -0.660398568877945 0.267887908263014 no 2479 0.254499045167602 3616 3118787 SGTC_2351 9026858 72.31 µM -0.661569434861126 0.267523507039638 no 2480 0.254123600756774 3567 1409300 SGTC_1365 1672-3266 55.4 µM -0.664007390419945 0.266765560398832 no 2481 0.253342790501519 3614 6415873 SGTC_151 3013-0144 2.285 µM -0.664961990685675 0.266469076506732 no 2482 0.253037402172537 3594 906558 YHR107C CDC12 SGTC_1121 fusaric acid 630.51 nM -0.665321509905427 0.266357458692283 no 2483 0.252922437794062 3614 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_6 0844-0013 19.835 µM -0.665619034773492 0.266265105793058 no 2484 0.252827318299881 3706 1584900 SGTC_268 camptothecin 39.6153 µM -0.666199291524854 0.266085038436197 no 2485 0.252641862860808 3636 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2459 5811157 9.22 µM -0.667413936248614 0.265708305295515 no 2486 0.252253883242899 3601 2870684 YBR192W RIM2 SGTC_1439 4092-1168 46 µM -0.669707603139715 0.264997641845309 no 2487 0.251522101962118 3618 2886240 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.670356721309053 0.264796696328601 no 2488 0.251315208354734 3629 4174840 SGTC_181 1447-1644 8.07 µM -0.670747075089127 0.26467589302004 no 2489 0.251190834125849 3592 534600 SGTC_404 fumagillin 50 µM -0.672357095564984 0.264177934209964 no 2490 0.250678194824461 3615 12015870 A methionine aminopeptidase binder. SGTC_1780 st038448 24.544 µM -0.673192573364712 0.263919719764969 no 2491 0.250412392673574 3665 728868 YDL195W SEC31 SGTC_2733 amorolfine 100 µM -0.674376762540947 0.263553952411385 no 2492 0.250035906197899 3639 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_845 0330-0138 4.51 µM -0.675213603236163 0.263295628672003 no 2493 0.249770032625102 3609 9039800 SGTC_1184 1269-1718 139 µM -0.677761376829662 0.262509955203148 no 2494 0.248961501792212 3657 5403821 SGTC_1124 fisetin 1.16336 µM -0.678665008360886 0.262231585067925 no 2495 0.248675071109932 3637 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1671 st016596 74.5 µM -0.678763917376718 0.262201124625372 no 2496 0.24864372985743 3678 2829167 SGTC_2575 plumbagin 510 nM -0.679158169646948 0.262079727030827 no 2497 0.248518824239171 3616 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2640 pentamidine 10.38 µM -0.679260278717639 0.262048290449341 no 2498 0.2484864798539 3658 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2019 4016004 108 µM -0.680473825382188 0.261674820775161 no 2499 0.248102244867759 3616 45595336 SGTC_2005 4024620 188 µM -0.681455307349244 0.261372969048601 no 2500 0.247791718531808 3648 236743 SGTC_3184 9108758 49.47 µM -0.681569279379398 0.261337928897959 no 2501 0.247755672923565 3652 902885 SGTC_1753 st043925 64 µM -0.681867073276234 0.261246384991904 no 2502 0.247661503715042 3658 670181 SGTC_400 oxethazaine 37.5 µM -0.682920632581351 0.260922645873419 no 2503 0.247328497790279 3629 4621 A local anesthetic. SGTC_742 0kpi-0133 140 µM -0.68310678192494 0.260865467108256 no 2504 0.247269685145565 3656 2728852 SGTC_1405 3909-7894 12 µM -0.683535011251906 0.2607339540545 no 2505 0.247134417334145 3650 7104060 SGTC_3066 9117245 49.47 µM -0.683680941039925 0.260689145507609 no 2506 0.247088330508295 3700 17176980 SGTC_457 grayanotoxin iii 135 µM -0.683694345189442 0.26068502988825 no 2507 0.247084097506462 3615 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3290 9121031 71.43 µM -0.683809703031285 0.260649611718826 no 2508 0.24704766934957 3626 17014854 SGTC_3199 9111318 49.47 µM -0.683817039223798 0.260647359380867 no 2509 0.247045352794773 3610 8548020 SGTC_2935 9038016 29.96 µM -0.684636262124644 0.260395906818524 no 2510 0.246786739311052 3647 6463195 SGTC_3324 9138759 60.749 µM -0.685903889541846 0.260007067220862 no 2511 0.24638685865222 3665 45595710 SGTC_1734 st037168 69.4 µM -0.686586645809848 0.259797758624536 no 2512 0.246171623079871 3656 708907 SGTC_3352 9151559 45.5865 µM -0.690067147813402 0.258732114360143 no 2513 0.245075980765197 3630 17159339 SGTC_792 4534-1957 155 µM -0.692491984938662 0.257991028209273 no 2514 0.244314208797655 3653 1717904 SGTC_3161 9100388 49.47 µM -0.695626385828769 0.257034717087107 no 2515 0.243331418754597 3695 25236368 SGTC_2419 paclitaxel 166.5 µM -0.696474155361491 0.256776378299093 no 2516 0.243065968546448 3627 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3196 9111891 49.47 µM -0.696508022325455 0.256766060908143 no 2517 0.243055367512133 3683 18891510 SGTC_2690 usnic acid 100 µM -0.696562482171143 0.256749470457525 no 2518 0.243038321020015 3712 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1383 3049-0032 20.7 µM -0.696841185030756 0.256664576161497 no 2519 0.24295109427981 3701 712864 SGTC_998 3996-0085 177 µM -0.697632682875432 0.256423561648612 no 2520 0.242703468429573 3707 715391 SGTC_838 0109-0203 71.4 µM -0.69816828089896 0.256260536661899 no 2521 0.242535980239298 3682 759422 SGTC_1298 1079-1278 263 µM -0.69972740923222 0.255786277921399 no 2522 0.242048777882764 3706 2840950 SGTC_2412 st077135 33.4 µM -0.701164501340042 0.255349546536977 no 2523 0.241600180343747 3725 13258915 SGTC_2436 5633522 8.09 µM -0.702254665295037 0.255018506557454 no 2524 0.2412601799916 3662 5724242 SGTC_1450 4112-4260 37.6 µM -0.702394887851379 0.254975942777117 no 2525 0.241216466260348 3663 1633175 SGTC_401 neomycin 50 µM -0.70266040520978 0.254895356637794 no 2526 0.241133704250584 3662 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_260 nsc-65238 3.989 µM -0.702838147077272 0.254841418344941 no 2527 0.241078310570535 3617 3246252 SGTC_305 1682-2595 20.8 µM -0.703114850493481 0.254757460656795 no 2528 0.240992089057369 3696 226033 SGTC_2234 tolnaftate 200 µM -0.704188584033013 0.254431804295947 no 2529 0.240657669716779 3668 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2964 9083345 53.42 µM -0.704977680050976 0.254192615780516 no 2530 0.240412063190685 3661 17741579 SGTC_3211 9128781 49.47 µM -0.705060444142348 0.254167535401338 no 2531 0.240386310739456 3691 17194361 SGTC_3347 9188721 44.724 µM -0.705445007682887 0.254051016388689 no 2532 0.240266671629993 3705 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_381 3461-2219 42.7 µM -0.707028721429324 0.253571462016908 no 2533 0.239774314660876 3664 2883159 SGTC_98 0074-0023 107.663 µM -0.709726883977385 0.25275554496763 no 2534 0.238936758731715 3659 3563821 SGTC_1904 st060225 78 µM -0.709837577046728 0.252722101227624 no 2535 0.238902431900849 3667 66595 SGTC_1256 0570-0116 285 µM -0.710402857278287 0.252551349233634 no 2536 0.238727175913135 3697 410638 SGTC_653 0203-0016 55.2 µM -0.711848547643508 0.252114931839066 no 2537 0.23827928317083 3725 295302 SGTC_3265 9137266 49.47 µM -0.712504404812226 0.251917076382982 no 2538 0.238076242394815 3632 17224265 SGTC_2606 farnesol 9.78 µM -0.716165445613513 0.25081414058007 no 2539 0.236944598353118 3728 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.717415849537615 0.250438026793928 no 2540 0.236558771409524 3645 1241132 A phosphatase inhibitor. SGTC_2899 9053889 58.44 µM -0.717497921940681 0.250413350379489 no 2541 0.236533459092982 3652 6470052 SGTC_1317 1273-0028 910 nM -0.718097197837373 0.250233207316184 no 2542 0.236348678917375 3695 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1305 1181-0477 144 µM -0.718396250944454 0.250143337298533 no 2543 0.236256498892262 3709 6252086 SGTC_217 ketoconazole 989 nM -0.718742315563247 0.250039360977301 no 2544 0.23614985277114 3632 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2724 maprotiline 69.64 µM -0.719006501218768 0.249960000913451 no 2545 0.236068456997199 3665 4011 A tricyclic antidepressant. SGTC_137 0438-0332 85.389 µM -0.719392640116242 0.24984403075052 no 2546 0.235949515161816 3737 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1041 0206-0046 107 µM -0.720185490980433 0.249606001220774 no 2547 0.235705397960472 3744 50494 SGTC_2322 7413319 38.22 µM -0.722411848637642 0.248938249163511 no 2548 0.23502065216101 3755 1840400 SGTC_2304 7443016 91.4 µM -0.727585045991839 0.24739032908614 no 2549 0.233433818687146 3669 939854 SGTC_3150 9097574 49.47 µM -0.727877514537346 0.247302970780301 no 2550 0.233344284352312 3696 17217476 SGTC_2725 haloperidol 53.21 µM -0.729092970465227 0.246940099360701 no 2551 0.232972397146428 3685 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_937 3122-0005 46.7 µM -0.729511762850436 0.246815135943745 no 2552 0.232844337545372 3729 759535 SGTC_790 1575-0012 79.1 µM -0.732224196448619 0.246006593484903 no 2553 0.232015869025368 3799 378741 YLR208W SEC13 SGTC_3244 9134489 49.47 µM -0.733819909744583 0.245531596099094 no 2554 0.231529252264168 3702 16584271 SGTC_805 3852-0218 479 µM -0.73423016307598 0.245409555295479 no 2555 0.231404236488227 3689 6615355 SGTC_2546 rhodinyl acetate 100 µM -0.734417348421949 0.245353882849921 no 2556 0.231347208335243 3694 6708682 SGTC_3127 9126946 49.47 µM -0.735283691010742 0.245096304690641 no 2557 0.231083369290386 3718 27243249 SGTC_1867 st057372 64 µM -0.738453495372896 0.244155109643701 no 2558 0.230119458486536 3722 688837 SGTC_2553 4-methylesculetin 85.09 µM -0.739263772311667 0.243914831087502 no 2559 0.22987342159189 3793 5319502 SGTC_555 4296-0685 37 µM -0.742550962783925 0.242941361673687 no 2560 0.228876793254809 3716 2908540 YHR072W ERG7 SGTC_76 0433-0009 400.328 µM -0.744385999761439 0.242398848903862 no 2561 0.228321493190399 3817 2841569 SGTC_1125 tnp00248 1.32998 µM -0.745216127771361 0.242153644552742 no 2562 0.22807053733232 3855 24207736 SGTC_1421 4029-0249 71.4 µM -0.745537891980792 0.242058637575178 no 2563 0.227973306581305 3817 2894095 SGTC_3020 9089140 49.47 µM -0.746563734331513 0.241755873190727 no 2564 0.227663473130046 3792 17217859 SGTC_959 1222-0044 107 µM -0.746861749025045 0.24166795646834 no 2565 0.227573508706494 3706 6083612 SGTC_394 menadione 8.33 µM -0.747197821483513 0.241568833226234 no 2566 0.227472079457457 3704 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1344 1488-0097 29.1 µM -0.747708605325572 0.241418221837258 no 2567 0.227317969739975 3763 747966 SGTC_2364 9055074 200 µM -0.748983909111662 0.241042404377404 no 2568 0.226933451944711 3766 6470630 SGTC_3286 9117135 37.221 µM -0.749114731705812 0.24100387045181 no 2569 0.226894028283021 3744 3438150 SGTC_1108 betulinic acid 729.144 nM -0.74928013642665 0.240955155122119 no 2570 0.226844188755585 3767 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2229 7354935 190 µM -0.750021788872475 0.240736788018916 no 2571 0.226620790985374 3677 318112 SGTC_978 1416-0512 87.4 µM -0.750132652112289 0.240704155455513 no 2572 0.226587407847576 3821 6814003 SGTC_2947 9072639 7.68 µM -0.750249489731528 0.240669766940963 no 2573 0.226552228709234 3764 16488146 SGTC_3332 9141069 11.198 µM -0.751912083651964 0.240180709862366 no 2574 0.22605196543568 3703 17332883 SGTC_129 0088-0017 176.636 µM -0.754580334271663 0.239396969248525 no 2575 0.225250413513794 3643 182446 SGTC_1504 k297-0033 30 µM -0.756015287857172 0.238976061088565 no 2576 0.224820014885702 3681 4388117 SGTC_1955 wogonin 32.4 µM -0.757747942421262 0.238468369424588 no 2577 0.224300946071031 3815 5281703 A flavanone. SGTC_3221 9128209 49.47 µM -0.757864909660384 0.238434117702113 no 2578 0.22426592954701 3800 16460723 SGTC_1557 sumaresinolic acid 42.3 µM -0.758673249764387 0.238197483696546 no 2579 0.224024021339267 3714 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1034 k072-0165 12.7 µM -0.759861426424785 0.237849889783932 no 2580 0.223668710436217 3756 5835461 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.760316498767876 0.237716834822426 no 2581 0.223532711066712 3820 5379071 SGTC_1654 st012436 41.8 µM -0.760899330308774 0.237546485024254 no 2582 0.223358599295992 3727 4323132 SGTC_863 0466-0191 129 µM -0.761140634639756 0.237475976295373 no 2583 0.223286536011811 3783 765160 YPR165W RHO1 SGTC_2379 9035213 200 µM -0.76133668065038 0.237418700432635 no 2584 0.22322799844599 3759 646551 SGTC_3110 9122132 49.47 µM -0.762111844242621 0.237192306649658 no 2585 0.222996627181918 3909 918317 SGTC_1786 berberine 21.6 µM -0.762395340497 0.2371095385416 no 2586 0.222912043183319 3732 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1677 st019204 53.9 µM -0.764597134963577 0.236467254507215 no 2587 0.222255737865921 3806 3945625 SGTC_2356 9061756 188.97 µM -0.764837069164367 0.236397321363573 no 2588 0.222184285568002 3790 20104043 SGTC_1267 0828-0272 9.49 µM -0.765328995095225 0.236253976299261 no 2589 0.222037831244084 3814 745334 SGTC_2440 5628896 157.78 µM -0.765634180295649 0.236165070731894 no 2590 0.221947000370844 3809 5522048 SGTC_1969 st069479 40.1 µM -0.767948149154015 0.235491572734587 no 2591 0.221258995113454 3770 3895485 SGTC_488 nitrendipine 139 µM -0.77000881074316 0.234892694953268 no 2592 0.220647333131305 3823 4507 Dihydropyridine L-type calcium channel blocker. SGTC_813 k007-0158 173 µM -0.770064546783232 0.234876508419674 no 2593 0.220630802581041 3807 6523916 SGTC_1765 st044815 90.4 µM -0.770770411019538 0.234671568820267 no 2594 0.220421514259203 3821 645695 SGTC_1023 4482-3888 16 µM -0.774409876262456 0.233616462597186 no 2595 0.219344222524275 3777 3303168 SGTC_1204 4049-0315 18.3 µM -0.774618625262291 0.233556024680132 no 2596 0.219282524131826 3887 588402 SGTC_1213 1315-0166 115 µM -0.775955611622942 0.233169140267315 no 2597 0.218887597599037 3863 768401 SGTC_1163 k060-0048 49.9 µM -0.775959303497729 0.233168072440435 no 2598 0.218886507639165 3801 6809982 SGTC_1057 3448-5381 134 µM -0.777070404583195 0.232846824246889 no 2599 0.218558616861299 3831 5497911 SGTC_1476 4112-3294 3.34 µM -0.777948033540881 0.232593252834252 no 2600 0.218299824753678 3842 704369 SGTC_2452 5863136 48.41 µM -0.778081505186978 0.232554702617459 no 2601 0.218260482580895 3772 2184096 SGTC_3035 9091303 49.47 µM -0.780734158361634 0.231789282045294 no 2602 0.217479432959378 3835 25237002 SGTC_2063 5246145 200 µM -0.7815562017016 0.231552367381879 no 2603 0.217237717637371 3847 711240 SGTC_3313 9133968 57.047 µM -0.783100983932846 0.231107523199803 no 2604 0.216783906713797 3790 1494643 SGTC_950 1165-0508 94.1 µM -0.783206256870604 0.231077225580353 no 2605 0.216753000629887 3823 6148369 SGTC_543 3844-1095 191 µM -0.786226245513697 0.230209015447136 no 2606 0.215867476352759 3828 4230703 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.786481439013844 0.230135734108543 no 2607 0.215792744428683 3813 676296 Flavone; oxidizing agent. SGTC_1695 st026914 34.495 µM -0.787913013927501 0.229724885246922 no 2608 0.215373794189033 3762 3289191 SGTC_2147 5545932 89.7195 µM -0.788348549899673 0.22959997196364 no 2609 0.215246428321475 3846 797404 SGTC_2090 5301565 104.445 µM -0.790219708684423 0.229063750014719 no 2610 0.214699733965338 3823 2056344 SGTC_919 tnp00227 403.569 nM -0.790711487857806 0.22892293648314 no 2611 0.214556185414242 3819 1269246 A methoxyflavone. YNL221C POP1 SGTC_1908 st060353 56.5 µM -0.790805630132469 0.228895985806787 no 2612 0.214528711990842 3845 4227716 SGTC_322 k048-0136 19.3 µM -0.791277300619 0.228760984666794 no 2613 0.214391095772641 3858 6823282 SGTC_1788 fluconazole 20 µM -0.791386509738173 0.228729733296538 no 2614 0.214359239861967 3870 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3263 9137018 49.47 µM -0.792065395996423 0.228535516426832 no 2615 0.214161272917958 3816 43844957 SGTC_2228 7354201 200 µM -0.792993816455201 0.228270062442276 no 2616 0.213890712731089 3838 753451 SGTC_2857 9024691 58.44 µM -0.79453534685322 0.2278296910884 no 2617 0.213441919939966 3904 16478292 SGTC_117 lucigenin 22.078 µM -0.796892851195603 0.227157144744349 no 2618 0.212756631537879 3848 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_113 0099-0221 2.5 µM -0.797816912027387 0.226893835250672 no 2619 0.212488372799909 3802 89219 SGTC_884 0851-0618 334 µM -0.799943708514648 0.226288462939538 no 2620 0.211871706118374 3872 9642473 SGTC_3191 9110352 49.47 µM -0.800237327452078 0.226204958851068 no 2621 0.211786653352195 3787 17122424 SGTC_1621 st003705 32.4 µM -0.80040174510574 0.226158206712798 no 2622 0.211739035123413 3873 24207032 SGTC_446 go6976 132 µM -0.800609030099354 0.226099273034166 no 2623 0.211679010692845 3813 3501 A protein kinase C inhibitor. SGTC_1763 st044482 94.5 µM -0.801525649242392 0.225838770990908 no 2624 0.211413700662072 3876 88505 SGTC_2431 5490079 200 µM -0.801794304722655 0.22576245160907 no 2625 0.21133597683053 3896 5722345 SGTC_3046 9092212 49.47 µM -0.802028803159132 0.225695847452426 no 2626 0.21126814854381 3864 25236637 SGTC_1288 0973-0013 65.5 µM -0.803568434725516 0.225258824948754 no 2627 0.210823129514133 3884 4315430 SGTC_682 0kpi-0099 17 µM -0.804701187654921 0.224937600693478 no 2628 0.210496067035023 3887 1714895 YML126C ERG13 SGTC_1233 0325-0408 14.2 µM -0.806049286327418 0.224555647635385 no 2629 0.210107215624722 3902 12874 SGTC_551 k048-0028 34.9 µM -0.806108140629451 0.224538980996382 no 2630 0.210090249054453 3812 6836383 SGTC_60 0986-0278 202 µM -0.807128173754454 0.224250234717703 no 2631 0.209796320887575 3728 3110598 SGTC_1165 k072-0275 30.3 µM -0.807288025776222 0.224205003659724 no 2632 0.2097502805677 3822 6153523 YGL055W OLE1 SGTC_94 0334-0113 514.748 µM -0.807689069827394 0.224091548721512 no 2633 0.209634798661477 3861 6795178 SGTC_696 1560-0013 611 µM -0.808253794793015 0.223931843929837 no 2634 0.209472247731065 3870 1650269 SGTC_324 1315-0088 19.6 µM -0.80877851953095 0.223783509226063 no 2635 0.209321276983845 3812 6787421 SGTC_705 1124-0212 310 µM -0.808933199023535 0.223739793462917 no 2636 0.209276785724431 3797 9554485 SGTC_2939 9044578 71.43 µM -0.811461467209839 0.223025938856049 no 2637 0.208550356286693 3813 2653634 SGTC_12 0849-0099 9.267 µM -0.813804621645413 0.222365510655357 no 2638 0.207878443529431 3744 6071388 SGTC_3047 9092122 49.47 µM -0.814172026674777 0.222262057229983 no 2639 0.207773204121452 3835 17173831 SGTC_1492 4158-0558 28.5 µM -0.815690461758835 0.221834789674953 no 2640 0.207338597848463 3853 3967268 SGTC_2876 9059903 25.97 µM -0.816962036486466 0.221477346579161 no 2641 0.206975061776853 3792 6916095 SGTC_849 0386-0493 241 µM -0.817260881271082 0.221393388311038 no 2642 0.206889678503345 3812 726119 SGTC_1754 st042065 16.137 µM -0.818082278268988 0.221162716576053 no 2643 0.206655103683549 3754 1126236 YIL048W NEO1 SGTC_2629 bisabolol 100 µM -0.819136109319196 0.220866972191057 no 2644 0.206354381046666 3879 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3257 9139206 32.98 µM -0.823564342578938 0.219626721927647 no 2645 0.205093571772445 3904 4910041 SGTC_1831 st055328 12 µM -0.825090319548172 0.219200257867835 no 2646 0.204660157603625 3832 1103068 SGTC_2317 5986382 200 µM -0.827403846682898 0.218554606365492 no 2647 0.204004100514021 3897 877883 SGTC_3168 9103419 49.47 µM -0.828667040082651 0.218202541170856 no 2648 0.203646420655617 3819 16649256 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.829092554971302 0.218084019354143 no 2649 0.203526018125921 3901 23665772 A membrane-active detergent. SGTC_2698 st077697 67.5 µM -0.830261948537958 0.217758490683501 no 2650 0.203195348472097 3848 3154499 SGTC_2832 7992762 51.95 µM -0.830541464569342 0.217680722238617 no 2651 0.20311635718022 3842 2985177 SGTC_2643 anethole 100 µM -0.830726767106385 0.217629175210244 no 2652 0.20306400074933 3878 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2634 4'-methoxyflavone 100 µM -0.830943994672808 0.217568756321041 no 2653 0.20300263430059 3891 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1900 st060200 72.8 µM -0.831296913860321 0.217470617298251 no 2654 0.202902958795501 3854 688945 SGTC_179 1273-0063 6.77 µM -0.831795552857257 0.217332000387803 no 2655 0.202762177262791 3867 3108139 SGTC_1277 0873-0036 22 µM -0.832198542125684 0.217220010484024 no 2656 0.202648443323641 3933 5965735 SGTC_2565 isoliquiritigenin 100 µM -0.835846847092241 0.216207671863371 no 2657 0.201620533916891 3968 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.836726567101182 0.215963974890386 no 2658 0.201373141102744 3872 16486 A toxic proline analog. SGTC_2658 polymyxin b sulfate 77.05 µM -0.839028677306126 0.215327005986257 no 2659 0.200726608641427 3904 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1986 st071812 45 µM -0.84012598341213 0.215023777341377 no 2660 0.200418876459436 3823 11838594 SGTC_2956 9076196 2.52 µM -0.840737145703857 0.214854996834633 no 2661 0.200247603010588 3903 16423868 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.840753436494819 0.214850498971692 no 2662 0.2002430388477 3933 5377381 SGTC_1567 st069303 68.4 µM -0.840819418793242 0.214832281917545 no 2663 0.20022455333998 3971 5581319 SGTC_1906 st060206 94.7 µM -0.841072157819238 0.214762511496444 no 2664 0.200153755818331 3911 5133468 SGTC_2584 androsterone 48.74 µM -0.841412154174169 0.214668673835356 no 2665 0.200058539419877 3881 2754130 A steroid. SGTC_34 0469-0683 81.75 µM -0.841491176533386 0.214646867387199 no 2666 0.200036413011271 3871 3690923 SGTC_116 0155-0182 31.788 µM -0.841593671881996 0.214618585417798 no 2667 0.200007716313414 3828 771486 SGTC_1656 st012921 11 µM -0.84177164880659 0.214569480648271 no 2668 0.19995789212781 3824 6732821 SGTC_1279 0874-0590 65.2 µM -0.843855367825548 0.213995057640887 no 2669 0.199375115671756 3935 3523074 SGTC_1778 st046819 58.9 µM -0.844517030862212 0.213812843082915 no 2670 0.199190275279108 3937 671715 SGTC_408 cantharidin 100 µM -0.844616972139688 0.213785328235821 no 2671 0.199162364930304 3863 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1005 4092-0690 4.4 µM -0.846300392099243 0.213322175641171 no 2672 0.198692594591268 3931 1529343 SGTC_270 tamoxifen 5.46 µM -0.846819463391295 0.213179483721896 no 2673 0.198547878932095 3925 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1235 benzylparaben 21.5 µM -0.848398657513083 0.212745708077983 no 2674 0.198107995033942 3916 7180 SGTC_1157 4092-0394 27.6 µM -0.848898064397271 0.212608637494537 no 2675 0.197969008005769 4003 3659885 SGTC_2549 cedrol 20.94 µM -0.851458138010114 0.211906792732974 no 2676 0.197257454026655 3823 6708665 A sedative which affects the nervous system. SGTC_814 3342-0569 96 µM -0.855205564500959 0.210881882656131 no 2677 0.196218678107801 3944 4346283 SGTC_2177 5811945 192 µM -0.8567226473892 0.210467792949679 no 2678 0.195799091993504 3948 5343475 SGTC_3092 9117248 49.47 µM -0.856966304344168 0.210401330983846 no 2679 0.195731753532994 3990 17141857 SGTC_3025 9087895 49.47 µM -0.860027059992635 0.209567502979603 no 2680 0.194887063110853 3931 17173641 SGTC_1813 st051246 8.6015 µM -0.860466719735941 0.209447888295085 no 2681 0.19476591059348 3840 5291959 SGTC_1056 3448-1962 115 µM -0.860871100676934 0.20933790710175 no 2682 0.194654519949798 3908 715507 SGTC_2037 5169046 200 µM -0.861131765970865 0.209267030879101 no 2683 0.194582737722296 3981 5718022 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.864825493419754 0.208264206664397 no 2684 0.193567288233095 3942 551469 SGTC_463 ikarugamyin 104 µM -0.865319105740411 0.208130409058063 no 2685 0.193431833588834 3977 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_93 0109-0045 59.227 µM -0.866522474300879 0.207804438951401 no 2686 0.193101853577384 4004 88733 SGTC_2439 5492030 7.2 µM -0.870903315129969 0.2066203004699 no 2687 0.19190347327151 3915 5722370 SGTC_885 0865-0106 16.8 µM -0.871429589435732 0.206478318223282 no 2688 0.191759817704182 3851 2793380 SGTC_3253 9135987 49.47 µM -0.87147674953116 0.206465597839972 no 2689 0.191746947765558 3908 4182430 SGTC_2620 irigenin 100 µM -0.875102097556743 0.205489131440092 no 2690 0.190759177942584 3994 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1144 3486-0183 12.5 µM -0.876367692942888 0.20514889747141 no 2691 0.190415087822766 3931 6744069 SGTC_1011 4112-3381 17.4 µM -0.878810753944016 0.204493069322264 no 2692 0.189751947226927 4028 2877139 SGTC_2585 alliin 100 µM -0.879719873519323 0.204249339385433 no 2693 0.189505540299817 4001 87310 A garlic compound which reacts with lipids. SGTC_1529 apigenin 74 µM -0.881826645284177 0.203685190836336 no 2694 0.188935280102213 3942 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3016 9080866 49.47 µM -0.883032588307324 0.203362683547526 no 2695 0.188609332196305 3938 17066299 SGTC_360 0957-0399 1.01 µM -0.883507998896856 0.203235627507124 no 2696 0.188480931336361 3969 6752301 YPR165W RHO1 SGTC_3291 9121177 71.43 µM -0.888167598408929 0.201992834190739 no 2697 0.187225302550005 3970 17015612 SGTC_1774 st048371 48.465 µM -0.889057130296866 0.201756099242219 no 2698 0.186986188448882 3923 4242727 SGTC_2180 6301957 200 µM -0.889396664447066 0.201665781390596 no 2699 0.186894968486407 3947 845462 SGTC_263 alizarin 107.927 µM -0.892850200493035 0.200748499474417 no 2700 0.185968699379612 3970 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1694 st024011 44.9 µM -0.893114890292319 0.200678299596869 no 2701 0.185897824850038 3976 2787533 SGTC_660 4031-1742 102 µM -0.893903104622818 0.200469340120695 no 2702 0.185686868267319 3891 6738706 SGTC_2722 naftopidil 47.16 µM -0.895338351899094 0.200089184829646 no 2703 0.185303122312655 3867 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_499 genistein 192 µM -0.897176217821906 0.199603020808395 no 2704 0.184812446705429 3994 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1696 st025591 34.7925 µM -0.897328745379973 0.199562705215888 no 2705 0.184771761043359 3967 2787147 SGTC_1915 st067105 30.6 µM -0.899219842434772 0.199063263691511 no 2706 0.184267786641709 3937 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_483 fpl-64176 144 µM -0.899368317280693 0.199024083176259 no 2707 0.184228254577223 4005 3423 SGTC_890 0929-0006 47.2 µM -0.901031178630004 0.198585593947921 no 2708 0.183785871253836 3942 1378169 SGTC_154 3389-1638 511.116 µM -0.904100571370783 0.197777740582337 no 2709 0.18297103772655 3987 5238686 SGTC_2329 6138490 200 µM -0.904794846157902 0.197595285660855 no 2710 0.182787041276688 4113 720019 SGTC_566 0958-0068 16.5 µM -0.906535966175581 0.19713816830115 no 2711 0.182326118551984 3870 6815365 SGTC_484 loperamide 105 µM -0.907081211814585 0.196995150024194 no 2712 0.182181926376338 3952 3955 An opioid-receptor agonist. SGTC_3226 9131256 49.47 µM -0.9077930666524 0.196808524598154 no 2713 0.181993781103293 3897 17178073 SGTC_2671 danthron 100 µM -0.908516864840203 0.196618877822531 no 2714 0.181802603788048 3968 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1583 clindamycin 39.6 µM -0.909792075530116 0.196285021558544 no 2715 0.181466087275062 3955 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2420 aureobasidin a 50 nM -0.911129419827418 0.195935267868154 no 2716 0.181113593442339 4121 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_74 000s-0487 160.283 µM -0.911408758390064 0.195862260630845 no 2717 0.181040020279626 3891 677548 SGTC_534 k292-0788 63.4 µM -0.914773536271879 0.19498414815784 no 2718 0.180155265166647 4001 4146317 SGTC_1325 1431-0015 227 µM -0.916068711802869 0.194646782738323 no 2719 0.179815428520917 3981 1103340 SGTC_3146 9095609 49.47 µM -0.916261160741314 0.194596684246514 no 2720 0.179764966891446 4040 17173999 SGTC_2224 6650123 117.647 µM -0.916401861876144 0.194560061758335 no 2721 0.179728079574526 3951 2908370 SGTC_3287 9117173 37.0625 µM -0.918705993537086 0.193960926249958 no 2722 0.179124687017623 3958 2789709 SGTC_1777 st045864 34.765 µM -0.920469415734538 0.193503149954502 no 2723 0.178663754198414 3961 4691462 SGTC_2953 9074162 66.49 µM -0.921174904449554 0.19332019305183 no 2724 0.17847955909991 3970 16451992 SGTC_812 4251-0442 148 µM -0.921345503323774 0.193275966892485 no 2725 0.178435035636357 4010 5723007 SGTC_3329 9141233 27.5565 µM -0.921469763628558 0.193243757460051 no 2726 0.178402610172014 3983 4909101 YNL103W MET4 SGTC_1063 disulfiram 1.84 µM -0.922371277955286 0.19301017463754 no 2727 0.178167473089716 3982 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1022 4477-0945 21.3 µM -0.923412102082936 0.192740711112458 no 2728 0.177896243669146 3945 4648966 SGTC_3051 9093778 49.47 µM -0.92407326041468 0.192569660375079 no 2729 0.177724087067312 4027 17217378 SGTC_762 1165-0429 115 µM -0.924482436524 0.192463847394072 no 2730 0.177617595868263 4005 5967793 SGTC_3348 9149464 3.537 µM -0.925157789955113 0.192289278704649 no 2731 0.177441918092307 3967 1951442 SGTC_2355 9061122 103.12 µM -0.925618283271885 0.192170303664844 no 2732 0.177322194187457 4020 5302957 SGTC_2877 9040724 71.43 µM -0.926822170967139 0.191859474880607 no 2733 0.177009435837091 3989 6463895 SGTC_2058 5236698 133 µM -0.928063637574492 0.191539266234629 no 2734 0.176687280128717 4009 766665 SGTC_2602 kawain 100 µM -0.929992569949688 0.191042391106433 no 2735 0.176187465747391 4001 5369129 SGTC_2721 ifenprodil 61.44 µM -0.933973313888738 0.190019490211006 no 2736 0.175158829391038 3978 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2201 6605497 169.863 µM -0.935370922439936 0.189661157495377 no 2737 0.174798588355863 3933 670741 SGTC_1731 st035964 63 µM -0.936158256264922 0.18945947621422 no 2738 0.174595856111974 3972 6739575 SGTC_256 clotrimazole 625 nM -0.936521171698963 0.189366557242911 no 2739 0.174502458546512 3937 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1272 0839-0021 27 µM -0.937295255377254 0.189168458645 no 2740 0.174303351432221 4032 5027250 SGTC_3142 9086498 49.47 µM -0.937488529427488 0.189119017088375 no 2741 0.174253660681293 3941 25236367 SGTC_2301 7769476 200 µM -0.93842202410819 0.18888033128438 no 2742 0.174013785987798 4060 977820 SGTC_904 1141-0088 396 µM -0.939122042330486 0.188701465054543 no 2743 0.173834044189756 4034 1378119 SGTC_1013 4112-3890 241 µM -0.93920186616959 0.188681075377621 no 2744 0.17381355553976 3960 705171 SGTC_2161 5662504 8.5105 µM -0.939835242037365 0.188519338151998 no 2745 0.173651039298668 3990 2859334 SGTC_2001 4023502 57.655 µM -0.940243201721912 0.188415207901652 no 2746 0.173546413207949 4052 108941 YCR052W RSC6 SGTC_2309 7664088 163.95 µM -0.940339380329879 0.188390663824587 no 2747 0.173521752910163 4038 704922 SGTC_2359 9039622 200 µM -0.9430190859761 0.187707615675755 no 2748 0.172835570306906 3987 6463596 SGTC_1117 retinoic acid 1.10837 µM -0.945311465529924 0.187124511432797 no 2749 0.172249943304306 4073 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.946349046459594 0.186860954455411 no 2750 0.171985292488984 4001 803109 SGTC_3156 9099931 49.47 µM -0.946611138738175 0.186794416491752 no 2751 0.171918482952391 4039 18111053 SGTC_2572 astragaloside iv 100 µM -0.948159595078794 0.186401605675013 no 2752 0.171524106567763 4100 45006101 An anti-inflammatory agent. SGTC_808 0711-0032 135 µM -0.948275116066686 0.186372320954936 no 2753 0.171494707716031 3944 4252555 SGTC_2052 5265182 7.135 µM -0.948719904010934 0.186259593250506 no 2754 0.171381544027513 4038 1239884 SGTC_1525 8-methoxypsoralen 92.5 µM -0.949997599247074 0.185936007378202 no 2755 0.1710567362422 4105 4114 Related to psoralen; DNA damaging agent. SGTC_1123 mangostin 811.285 nM -0.951746830653454 0.185493567125136 no 2756 0.170612696421762 4048 5281650 An antioxidant. SGTC_1710 st031758 61.5 µM -0.952848586595866 0.185215231172271 no 2757 0.170333396415191 4060 5394341 SGTC_390 dec-rvkr-cmk 16.7 µM -0.954161756288443 0.184883824889016 no 2758 0.170000884893703 4068 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2695 st077686 51.995 µM -0.957041051070917 0.184158464542047 no 2759 0.16927326768958 4074 2876092 SGTC_966 1300-0360 30.2 µM -0.957512106585732 0.184039963685444 no 2760 0.169154419353355 4023 70588 SGTC_3062 9077494 49.47 µM -0.957995550704944 0.18391839567023 no 2761 0.169032501071372 4029 16459633 SGTC_2644 guaiazulene 100 µM -0.958765114499079 0.183724982505247 no 2762 0.168838543605484 4046 3515 A coloring agent. SGTC_1141 3253-0389 52.6 µM -0.959128565374201 0.183633681084106 no 2763 0.168746990784047 4025 5402031 SGTC_1964 st076914 61 µM -0.959668278050903 0.183498153630422 no 2764 0.168611096709612 4079 24208661 SGTC_2701 st077767 14.721 µM -0.959958120901163 0.183425396820658 no 2765 0.168538146316918 4013 5721188 SGTC_1452 4194-0072 190 µM -0.962386766794302 0.182816461171538 no 2766 0.167927679248525 4114 1343545 SGTC_2076 5212012 200 µM -0.962467506079972 0.182796239064519 no 2767 0.167907409009785 3983 604802 SGTC_1127 asiatic acid 681.4 nM -0.962599160564099 0.182763267640005 no 2768 0.167874359484449 4007 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_799 1310-0557 151 µM -0.965077267172377 0.182143345746314 no 2769 0.167253056114841 4119 5354492 SGTC_2537 larixol 68.93 µM -0.965685051553894 0.181991503665604 no 2770 0.167100900883623 4045 6708759 SGTC_9 0092-0002 10.449 µM -0.96650697982496 0.181786288196539 no 2771 0.166895277997971 4014 759368 SGTC_2244 6635614 200 µM -0.966651825075856 0.181750138873995 no 2772 0.166859058791869 3969 836499 SGTC_1029 k015-0030 64.7 µM -0.967864428625957 0.181447683395318 no 2773 0.166556040751721 4117 2208316 SGTC_917 harmaline 728.087 nM -0.96980908382137 0.180963293095819 no 2774 0.16607083206032 4036 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_476 mead acid 10 µM -0.97079177056436 0.180718826100846 no 2775 0.16582599072255 4072 5312531 An omega 9 fatty acid. SGTC_403 arphamenine a 50 µM -0.971216623850548 0.180613197755441 no 2776 0.16572020867827 4016 5487158 An arginine aminopeptidase inhibitor. SGTC_1940 st075990 51.1 µM -0.973285008276104 0.180099502839859 no 2777 0.165205835647434 4161 1084979 SGTC_1673 st016611 27.3 µM -0.973868843488004 0.179954670230103 no 2778 0.165060832677813 4087 5226799 SGTC_1047 2043-3044 82 µM -0.975720096614352 0.179495911769131 no 2779 0.164601595233293 4058 669592 SGTC_2539 epi(13)torulosol 80 µM -0.980082061411699 0.178417884502318 no 2780 0.163522806606873 4107 6708597 SGTC_898 1000-0849 28.3 µM -0.980289381392617 0.178366748650808 no 2781 0.163471647381068 4058 6751807 SGTC_2152 5568786 200 µM -0.983643349700751 0.17754076966627 no 2782 0.162645451431991 4046 5399883 SGTC_2896 9052656 71.43 µM -0.985883977728286 0.17699031937323 no 2783 0.162095025060511 3919 6469436 SGTC_991 3996-0057 64.7 µM -0.98709511472318 0.176693231416019 no 2784 0.161798006237085 4141 715343 SGTC_826 1683-5028 118 µM -0.987707619268001 0.176543106164972 no 2785 0.16164793094744 4110 722377 SGTC_2314 7727897 200 µM -0.988157874459737 0.176432799796169 no 2786 0.161537667726473 4086 900724 SGTC_1432 4049-0298 68.4 µM -0.988663758713695 0.17630891709181 no 2787 0.161413839988312 4097 741646 SGTC_1446 4239-0190 62 µM -0.990527233018073 0.175853057938319 no 2788 0.160958242476142 4087 1340085 SGTC_2659 sanguinarine 24.21 µM -0.990861101703059 0.175771463027297 no 2789 0.160876704265139 4012 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1963 st076565 50.3 µM -0.992604524702798 0.175345773692455 no 2790 0.160451359445934 4090 4914280 SGTC_382 3229-0966 23.2 µM -0.994070374314227 0.17498836536589 no 2791 0.160094303630897 4112 5722370 SGTC_2393 9031399 185.94 µM -0.995705293242905 0.174590279685752 no 2792 0.159696678745459 4139 1526623 YDL150W RPC53 SGTC_1647 st011722 22.4 µM -0.996312322332906 0.174442620958952 no 2793 0.159549209240523 4062 2854783 SGTC_1104 tacrolimus 29.8 µM -0.997151260810217 0.174238681308463 no 2794 0.159345547250168 4121 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_637 1181-0519 7.26 µM -0.998013543802456 0.1740292247445 no 2795 0.159136395585723 4077 6252091 YGR060W ERG25 SGTC_1629 st005085 44.9 µM -0.998733100593439 0.173854560281772 no 2796 0.158962000684336 4046 24207091 SGTC_989 1501-0895 10.3 µM -1.00035582420469 0.173461071429229 no 2797 0.158569170208907 4058 2830112 SGTC_1015 4130-4525 82 µM -1.00220474121334 0.173013425149578 no 2798 0.158122359198 4091 1363237 SGTC_1092 toremifene 6.32 µM -1.00452786643707 0.172452011352884 no 2799 0.157562123191101 4071 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2069 5228469 200 µM -1.00540950504393 0.172239256268243 no 2800 0.157349852423223 4108 2835210 SGTC_1188 1403-0014 4.57 µM -1.00565407913258 0.172180265876013 no 2801 0.157291000020636 4085 9614867 SGTC_92 0063-0024 660.874 µM -1.00580369167039 0.172144186225687 no 2802 0.157255005560474 4170 3594437 SGTC_2334 9017922 200 µM -1.00590768028788 0.172119111805248 no 2803 0.157229990699625 4168 3163164 SGTC_3070 9117005 49.47 µM -1.00591096167545 0.172118320613404 no 2804 0.157229201391842 4178 8779016 SGTC_435 c-PAF 6.7 µM -1.00877309478565 0.171429101409225 no 2805 0.156541733614277 4094 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_480 am 92016 50 µM -1.00933162638459 0.171294809556919 no 2806 0.156407808696347 4075 2129 K+ channel blocker. SGTC_2645 abamectin 100 µM -1.01023480522869 0.171077793991116 no 2807 0.15619140384064 4054 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2178 5812956 200 µM -1.01040438677134 0.171037066601636 no 2808 0.156150793508823 4068 5403383 SGTC_639 0833-0042 114 µM -1.01067562328372 0.170971938237146 no 2809 0.156085853942038 4101 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1874 staurosporine 7.6 µM -1.011568390132 0.170757682247317 no 2810 0.155872233016144 4141 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2897 9048598 12.99 µM -1.0117179680847 0.170721801702811 no 2811 0.155836460918806 4084 6467404 SGTC_1424 4048-1941 275 µM -1.01351594659566 0.170290882880693 no 2812 0.155406891574313 4173 X1424 SGTC_1301 naphtanilide LB 4.81 µM -1.01417024636166 0.170134240907981 no 2813 0.155250761704548 4170 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2778 tioconazole 65.09 nM -1.01444435536506 0.170068645572326 no 2814 0.15518538423698 3995 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2729 fluphenazine 10.66 µM -1.01444488571696 0.170068518672797 no 2815 0.155185257760892 4033 3372 An atypical antipsychotic. SGTC_2872 9044037 25.97 µM -1.01480519543388 0.169982319876914 no 2816 0.155099348342483 4098 6465195 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.01612075521094 0.169667829421824 no 2817 0.154785943280405 4104 364106 SGTC_556 4058-0063 51.5 µM -1.01879972857141 0.169028563499934 no 2818 0.154149027310767 4135 6615692 SGTC_2621 lithochol-11-enic acid 100 µM -1.02109071637537 0.168483108804424 no 2819 0.153605730541975 4036 6708711 SGTC_1449 4112-4002 201 µM -1.02307571361783 0.16801142267741 no 2820 0.153136024419001 4164 2059539 SGTC_359 0081-0058 15.9 µM -1.02354856453063 0.16789918666343 no 2821 0.153024275144187 4228 3494159 SGTC_1046 2001-0062 216 µM -1.02476228689468 0.167611318209974 no 2822 0.152737682585179 4022 739778 SGTC_3032 9089427 49.47 µM -1.02508069688805 0.167535850979882 no 2823 0.152662556392066 4131 17173707 SGTC_1957 st077035 62.4 µM -1.02522352606402 0.16750200575611 no 2824 0.152628864999758 4116 705593 SGTC_1903 st060211 78.3 µM -1.02536034650273 0.167469588511656 no 2825 0.152596595610196 4140 688960 SGTC_3251 9135047 49.47 µM -1.02539734475356 0.167460823108261 no 2826 0.152587870272124 4144 17682963 SGTC_1160 4092-0570 10.5 µM -1.0257554511813 0.167375997961088 no 2827 0.152503434747623 4114 4994975 SGTC_1648 st011736 69.8 µM -1.02576518478705 0.167373692735505 no 2828 0.152501140158584 4107 2855514 SGTC_587 k089-0003 57 µM -1.02605399043012 0.167305303737868 no 2829 0.152433067872407 3989 9659696 SGTC_914 3820-6779 408 µM -1.02709810120903 0.167058209227258 no 2830 0.15218713634503 4071 2893481 SGTC_2465 5809242 33.21 µM -1.02778147299278 0.166896613043916 no 2831 0.152026316580873 4162 2731748 SGTC_1973 st070275 50.2 µM -1.03046399775956 0.166263254417203 no 2832 0.151396122151728 4072 17118334 SGTC_3340 9146634 11.102 µM -1.03155607866365 0.166005853412695 no 2833 0.151140062389861 4139 4907387 SGTC_1322 1348-1070 12 µM -1.03227700878817 0.165836072989162 no 2834 0.150971184178972 4117 6758089 SGTC_1300 1094-0077 113 µM -1.03260882851462 0.165757966542026 no 2835 0.150893497476312 4100 5532636 SGTC_3323 9138564 53.9225 µM -1.03367779673201 0.165506505793224 no 2836 0.150643408165524 4146 43912313 YNL103W MET4 SGTC_628 1636-0253 16 µM -1.03785588131255 0.164526034578 no 2837 0.149668578032263 4128 4456143 SGTC_676 falcarinol 140 µM -1.0381822219143 0.164449611041455 no 2838 0.149592613897494 4139 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.04052257416864 0.16390221387011 no 2839 0.149048590903398 4181 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2906 7926292 26.41 µM -1.04227287394618 0.163493600848417 no 2840 0.148642592502286 4151 2966319 SGTC_2681 menadione 3.18 µM -1.04335212166761 0.163241977071072 no 2841 0.148392619719913 4154 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1016 4226-1401 38 µM -1.04689633918353 0.162417423057994 no 2842 0.147573695237733 4107 2901613 SGTC_2852 9023854 51.95 µM -1.04739164286809 0.162302408052069 no 2843 0.147459492270756 4200 19798528 SGTC_850 0388-0143 75.9 µM -1.04913726026511 0.161897479165121 no 2844 0.147057474666084 4112 67273 SGTC_191 3914-0123 66.505 µM -1.04945653324244 0.161823489035791 no 2845 0.14698402532412 4131 3144412 SGTC_327 1273-0057 3.96 µM -1.05107229646808 0.161449380873891 no 2846 0.146612693333084 4009 3108138 SGTC_1555 citronellol 128 µM -1.05309357591413 0.16098217558801 no 2847 0.146149053415295 4106 8842 A terpine precursor. SGTC_3057 9095946 49.47 µM -1.05420749509118 0.160725078116921 no 2848 0.145893964642586 4174 24540043 SGTC_2848 9016370 25.97 µM -1.0548049677541 0.160587289322239 no 2849 0.145757266069865 4143 7894410 SGTC_3255 9139072 49.47 µM -1.0554446954322 0.160439841263157 no 2850 0.145610995248184 4170 17646060 SGTC_1685 st024049 53.0905 µM -1.05724202258652 0.160026056648122 no 2851 0.145200572893699 4174 1941139 SGTC_846 0335-0850 148 µM -1.06012324571299 0.159364192421865 no 2852 0.144544266838096 4124 6819598 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.06181048219538 0.158977439846089 no 2853 0.144160865089843 3993 88881 An O-methylated flavonoid and antioxidant. SGTC_2403 6032726 181.2 µM -1.06390876265622 0.158497325482 no 2854 0.143685016525152 4217 2881040 SGTC_909 3448-9333 149 µM -1.06455408981143 0.158349857496092 no 2855 0.14353888243727 4081 3344074 SGTC_507 nimesulide 162 µM -1.06631718895164 0.157947419099988 no 2856 0.143140140932947 4220 4495 A COX2 inhibitor. SGTC_2911 7942208 15.64 µM -1.06817911864533 0.157523151715168 no 2857 0.142719861051132 4189 1243384 SGTC_1742 st038235 28.8875 µM -1.06830385993587 0.157494754414979 no 2858 0.142691733953392 4212 564103 YBR002C RER2 SGTC_1224 0823-0416 294 µM -1.07008808034748 0.157088945640286 no 2859 0.142289831932769 4230 3598164 SGTC_1187 1391-0724 117 µM -1.07087641938433 0.156909862546895 no 2860 0.142112499948334 4209 6997986 SGTC_2624 nerol 100 µM -1.07364462479814 0.156282087293363 no 2861 0.141490994470275 4079 637566 A natural product oil. SGTC_3351 9150312 21.596 µM -1.07406321068312 0.156187304343905 no 2862 0.141397175935119 4089 4904905 SGTC_901 1112-0062 60.1 µM -1.07408050325434 0.156183389496569 no 2863 0.141393301021812 4192 1908457 SGTC_1620 st003704 16.5 µM -1.07456112747153 0.15607460734618 no 2864 0.141285631713178 4149 2834414 SGTC_2895 9054447 58.44 µM -1.07647591119034 0.155641720317245 no 2865 0.140857234256101 4224 2697450 SGTC_213 1246-0773 967 nM -1.07874941630948 0.155128764208286 no 2866 0.140349724974356 4179 6251622 SGTC_3031 9088762 49.47 µM -1.07962367223549 0.154931809013966 no 2867 0.140154897810235 4146 205253 SGTC_348 k064-0012 10.7 µM -1.08155670338707 0.154496916055342 no 2868 0.139724775973136 4099 5066323 SGTC_3087 9117406 49.47 µM -1.08257644858769 0.154267819426413 no 2869 0.139498232806367 4198 42546093 SGTC_3203 9113543 49.47 µM -1.08322835770935 0.154121478871928 no 2870 0.139353537842259 4252 17018012 SGTC_288 1315-0019 35.1 µM -1.0835758284608 0.154043516169747 no 2871 0.139276456449454 4233 6811474 SGTC_2006 4011487 200 µM -1.08410930125043 0.15392387061067 no 2872 0.139158169649683 4203 45595294 SGTC_1465 k213-0056 144 µM -1.08502665354016 0.153718273625864 no 2873 0.13895492524902 4051 24048857 YMR208W ERG12 SGTC_641 4092-0595 30 µM -1.08504672707381 0.153713776779292 no 2874 0.138950480108993 4204 786260 SGTC_662 k832-1615 104 µM -1.08534877352955 0.15364612324439 no 2875 0.138883605776662 4197 5878478 SGTC_572 0960-0087 17.7 µM -1.08596257369135 0.153508702655404 no 2876 0.138747775416612 4154 6796365 SGTC_111 0083-0039 52.457 µM -1.08970771677277 0.15267198569636 no 2877 0.137920957891764 4052 759313 SGTC_1174 0739-0097 51.1 µM -1.08992941402399 0.152622550476536 no 2878 0.137872119245438 4210 728447 SGTC_2274 7947094 46.08 µM -1.09096354022761 0.152392095886015 no 2879 0.137644462995197 4126 2971028 SGTC_1245 0418-0076 17.2 µM -1.09137009219457 0.15230155923078 no 2880 0.137555033485079 4228 6790114 SGTC_24 0417-1663 219 µM -1.09171231889083 0.152225375107463 no 2881 0.137479784400533 4213 4329390 SGTC_2384 9036245 200 µM -1.09282559139641 0.151977721190298 no 2882 0.137235191572482 4112 6462766 SGTC_2287 7945887 168.79 µM -1.09509897691621 0.151472825126641 no 2883 0.13673663843054 4207 1245853 SGTC_1766 st045414 44.774 µM -1.09780961720279 0.150872278436784 no 2884 0.136143815550373 4204 253960 SGTC_70 0141-0289 43.283 µM -1.09863000387586 0.150690833318751 no 2885 0.135964742490537 4161 352408 SGTC_1888 azatryptophan 97.5 µM -1.10040149195897 0.150299528708063 no 2886 0.135578614362836 4240 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3101 9120531 49.47 µM -1.10206229855537 0.149933288099024 no 2887 0.135217294247149 4226 24824904 SGTC_868 0527-0199 213 µM -1.10607047677969 0.149051858906147 no 2888 0.134348008035863 4155 2849450 SGTC_3303 9125618 40.5795 µM -1.10835748611377 0.148550482034101 no 2889 0.133853728909344 4207 22695467 SGTC_3341 9147222 25.867 µM -1.10864291985632 0.148487986161433 no 2890 0.133792127481805 4205 1939759 SGTC_481 bay k-8644 50 µM -1.10944514605469 0.148312432461078 no 2891 0.133619097869301 4181 2303 A calcium channel antagonist. SGTC_2237 6667747 47.222 µM -1.10994398115491 0.14820334083096 no 2892 0.133511583335389 4201 729940 YDL015C TSC13 SGTC_1554 st069299 38.7 µM -1.1136655213595 0.147391161522863 no 2893 0.132711353007846 4175 24207999 SGTC_226 1,3-diallylurea 8.28947 mM -1.11426583460798 0.14726043060382 no 2894 0.132582579732275 4135 74537 YKL182W FAS1 SGTC_249 wiskostatin 11.211 µM -1.1162393126216 0.146831211843141 no 2895 0.132159855467946 4185 2775510 A n-wasp and actin depolymerizer. SGTC_2818 7996756 12.99 µM -1.11878780819416 0.146278173278589 no 2896 0.131615337060586 4229 2241621 SGTC_120 rhodamine 6G 52.259 µM -1.11906820285852 0.14621741151246 no 2897 0.131555521869923 4219 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1373 2887-0003 58.5 µM -1.12050084674202 0.145907220935072 no 2898 0.131250195984405 4173 776948 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.12182566130243 0.145620770962949 no 2899 0.130968286585533 4174 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2984 9022109 38.96 µM -1.12441235826633 0.145062568670276 no 2900 0.130419065853942 4241 6459207 SGTC_1090 efavirenz 20.7 µM -1.12566685961683 0.144792369917412 no 2901 0.130153278155033 4241 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_271 rotenone 740 µM -1.12649418709698 0.144614362895563 no 2902 0.129978199837215 4276 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1098 clofazimine 15.1 µM -1.12964104592127 0.143938634858941 no 2903 0.12931375401632 4277 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2841 9004761 38.96 µM -1.13153773567753 0.143532387102297 no 2904 0.128914414994301 4203 2991039 SGTC_2567 aureobasidin a 60 nM -1.1335675009122 0.143098494319048 no 2905 0.128488005893435 4372 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2016 5121758 140 µM -1.1350303776865 0.142786332457655 no 2906 0.128181295297144 4143 2795203 SGTC_315 k915-0449 187 µM -1.13533804406865 0.142720738456227 no 2907 0.128116853922343 4233 20970215 YNL149C PGA2 SGTC_840 0245-0196 390 µM -1.13545038282083 0.142696793084274 no 2908 0.128093329942105 4309 3827528 SGTC_1699 st031318 29.054 µM -1.13706849968207 0.142352187516547 no 2909 0.127754825552398 4268 5340658 SGTC_2272 7805186 180 µM -1.13712670188717 0.142339802863439 no 2910 0.12774266144946 4233 2956062 YPR165W RHO1 SGTC_460 trequinsin 123 µM -1.13833418624758 0.14208303072643 no 2911 0.127490482075329 4301 5537 A vasodilator. SGTC_1048 3161-0300 24.5 µM -1.13960213952852 0.14181373751111 no 2912 0.127226046793999 4227 2165101 SGTC_1143 3454-2408 5.08 µM -1.14147299892614 0.141417028198158 no 2913 0.126836571001783 4233 X1143 SGTC_2801 7907800 81.82 µM -1.14162336441003 0.141385176398621 no 2914 0.12680530397042 4251 6620925 SGTC_747 3448-8087 38.7 µM -1.14404223642433 0.140873456902292 no 2915 0.126303060633448 4302 5168703 SGTC_2260 7964312 200 µM -1.14642359685535 0.140370901913716 no 2916 0.125809961844729 4295 231951 SGTC_3186 9110464 49.47 µM -1.14786460349938 0.140067388232156 no 2917 0.125512231287376 4241 17018021 SGTC_1200 1643-0193 18.4 µM -1.14836781446156 0.139961503963065 no 2918 0.125408377341494 4261 5403974 SGTC_2 0422-0095 29 µM -1.14886581694617 0.139856769213733 no 2919 0.125305657402952 4142 6790840 SGTC_1195 1502-0147 41.1 µM -1.15048178770349 0.139517281853424 no 2920 0.124972745559975 4224 817940 SGTC_2007 4011539 71.82 µM -1.1529482461748 0.13900020317111 no 2921 0.124465813803022 4183 45595301 SGTC_1688 st021091 57.6 µM -1.15347818103503 0.138889275897472 no 2922 0.124357084079045 4268 3656366 SGTC_634 1611-4317 11.2 µM -1.15489013124317 0.138594017313934 no 2923 0.124067710615484 4281 2843522 SGTC_3077 9117319 49.47 µM -1.15580386554365 0.138403170739969 no 2924 0.123880695776868 4230 17154678 SGTC_2281 7943571 200 µM -1.15769695978512 0.138008340902371 no 2925 0.123493862538003 4352 1244024 SGTC_1882 5615643 20 µM -1.15922834644701 0.137689512558311 no 2926 0.123181559947311 4200 2253075 SGTC_1672 st016598 6.51 µM -1.15926146791926 0.13768262236337 no 2927 0.123174811456679 4244 4665860 YNL267W PIK1 SGTC_821 1114-0266 29.2 µM -1.15937440985632 0.137659129042872 no 2928 0.123151801517044 4258 3123235 SGTC_425 3825-7017 13.1 µM -1.16095157582814 0.137331344859094 no 2929 0.122830796342079 4292 3397440 SGTC_2408 sulbentine 18.36 µM -1.16428714515063 0.136639866534816 no 2930 0.122153832138594 4164 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2975 9084847 53.72 µM -1.16643854057211 0.1361951377734 no 2931 0.121718591877952 4310 27211724 SGTC_1755 st041960 45.185 µM -1.16860845574514 0.135747585113456 no 2932 0.12128070993664 4294 2257073 SGTC_2078 5212016 200 µM -1.16862066290705 0.13574507019589 no 2933 0.121278249707987 4136 1899708 SGTC_2143 5623677 140.463 µM -1.17100749363984 0.135253948752418 no 2934 0.120797882524479 4203 5375313 SGTC_804 1595-0054 20.9 µM -1.17744335085675 0.13393576332715 no 2935 0.119509297812958 4215 761523 Stimulates phospholipase C. SGTC_987 1497-1013 404 µM -1.17760839587822 0.133902075490668 no 2936 0.119476380584894 4280 1676435 SGTC_2881 9058953 51.95 µM -1.17763597325742 0.133896447156575 no 2937 0.119470881067705 4208 17122249 SGTC_2787 5284540 71.43 µM -1.17846995742694 0.133726314112447 no 2938 0.119304651211878 4296 736958 SGTC_1630 st005209 31.3 µM -1.1818022815572 0.133048002510129 no 2939 0.118642081157464 4251 3367314 SGTC_3118 9124250 49.47 µM -1.18285432083602 0.132834347271515 no 2940 0.118433443905155 4210 1504786 SGTC_963 1269-2853 151 µM -1.18464485739852 0.132471256503731 no 2941 0.118078946656397 4247 3668223 SGTC_921 1561-0023 372 µM -1.18751828066274 0.131890004947606 no 2942 0.117511625114948 4244 24050882 SGTC_2339 9000433 200 µM -1.18829850334641 0.131732481455854 no 2943 0.117357913583386 4290 2988954 SGTC_2810 7959871 45.46 µM -1.18995672254943 0.131398125641092 no 2944 0.117031701148287 4238 2974535 SGTC_2534 helenine 20.12 µM -1.19086777613458 0.131214674521287 no 2945 0.116852748267528 4300 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1791 st048313 56.1 µM -1.19353076357817 0.130679465880625 no 2946 0.116330785680772 4278 1204976 SGTC_2142 5622915 118.518 µM -1.19365658350887 0.130654215915882 no 2947 0.116306165159293 4294 5322196 SGTC_502 l-744,832 89.3 µM -1.19367543464347 0.13065043309767 no 2948 0.116302476676156 4290 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1840 st055363 71 µM -1.19556969650845 0.130270701531548 no 2949 0.115932261453997 4319 676033 SGTC_2764 methyldopa 94.69 µM -1.19557544636195 0.130269550055759 no 2950 0.115931138975756 4281 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1591 genipin 88.4 µM -1.1959754204419 0.130189467823639 no 2951 0.115853075540321 4320 442424 A DNA cross-linking agent. SGTC_1364 1653-0028 37.6 µM -1.19663669209298 0.130057143697719 no 2952 0.11572409621666 4279 5718652 SGTC_123 0083-0120 66.675 µM -1.19734287487196 0.129915935422038 no 2953 0.11558646974302 4259 16001701 SGTC_698 k064-0052 127 µM -1.19810721967479 0.129763216723858 no 2954 0.115437639278981 4367 5088751 SGTC_3220 9131269 49.47 µM -1.19857336819957 0.12967013971116 no 2955 0.115346939397831 4308 17722206 SGTC_1370 2001-0092 44.6 µM -1.19920217958953 0.129544656682387 no 2956 0.115224669988711 4318 790957 SGTC_2264 7948757 110.76 µM -1.20240930379622 0.128905964916575 no 2957 0.114602493142892 4255 2971411 SGTC_1901 st060216 58.6 µM -1.20249068988593 0.128889785519974 no 2958 0.114586735542084 4252 688792 SGTC_2425 5628681 7.85 µM -1.20510112711443 0.128371582670312 no 2959 0.114082132378116 4356 5714958 SGTC_85 0868-0259 160.055 µM -1.20678941292653 0.128037209102602 no 2960 0.11375662715616 4192 83173 SGTC_2950 9072895 21.46 µM -1.20690007914193 0.128015312246568 no 2961 0.113735313607687 4262 17332245 SGTC_1326 1431-2094 10.8 µM -1.20725324743192 0.127945450368024 no 2962 0.113667314871523 4267 616278 SGTC_193 1273-0060 1.558 µM -1.21148115573712 0.127111164386042 no 2963 0.112855526275594 4133 2847393 YHR072W ERG7 SGTC_1984 st072354 53.1 µM -1.21254691985871 0.126901457695218 no 2964 0.112651546717986 4169 5762938 SGTC_1632 st005650 90 µM -1.21605448127628 0.12621298819512 no 2965 0.111982084361979 4332 2759605 SGTC_544 k015-0020 52.4 µM -1.21680106166967 0.126066784920021 no 2966 0.111839958001949 4310 3008304 SGTC_1560 lithocholic acid 53.1 µM -1.21956744149962 0.125526072649693 no 2967 0.111314447586848 4216 9903 A bile acid which acts as a detergent. SGTC_1416 3966-0321 25.3 µM -1.21980230781412 0.125480240697139 no 2968 0.111269913167932 4340 582530 YLR208W SEC13 SGTC_2999 9069765 71.4286 µM -1.22108819749073 0.125229518436508 no 2969 0.111026313954655 4263 2097066 SGTC_2104 5389443 200 µM -1.22156867303931 0.125135925333454 no 2970 0.110935390659764 4322 2244536 SGTC_178 4092-0806 87.505 µM -1.22185598930376 0.125079981583191 no 2971 0.110881045555356 4193 2169044 SGTC_1379 2144-0755 36.5 µM -1.22236653435171 0.124980615747728 no 2972 0.110784524383619 4355 5392327 SGTC_1725 st036284 20.55 µM -1.22417812848466 0.124628475700304 no 2973 0.110442519023656 4361 707914 SGTC_638 3970-0837 4.09 µM -1.22432368801532 0.124600211778194 no 2974 0.110415072171868 4285 4118451 YLR208W SEC13 SGTC_3147 9097027 49.47 µM -1.22506613975166 0.124456116435941 no 2975 0.110275150814844 4288 25236841 SGTC_1292 0kpi-0043 232 µM -1.22539547416101 0.124392236396127 no 2976 0.110213125669046 4323 3333905 SGTC_3201 9113999 49.47 µM -1.22828873923654 0.123832023603551 no 2977 0.109669298336588 4297 16649224 SGTC_724 3910-0327 137 µM -1.2283808819363 0.123814211399932 no 2978 0.109652010611395 4343 2885483 SGTC_135 0933-0004 26.348 µM -1.23102472488184 0.123303891186881 no 2979 0.109156808530997 4275 21230617 YGL099W LSG1 SGTC_2168 5727979 200 µM -1.23127015939718 0.123256591758581 no 2980 0.10911091933869 4226 695210 SGTC_2551 apiole 73.87 µM -1.23337922711164 0.122850662362893 no 2981 0.108717155720486 4210 10659 A possible DNA adduct former. SGTC_461 N-acetylfarnesylcysteine 136 µM -1.23677034773014 0.122199945167988 no 2982 0.108086176730907 4378 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1407 3909-7909 12.3 µM -1.23747235778261 0.122065540358779 no 2983 0.107955885187556 4332 4411780 SGTC_3029 9088683 49.47 µM -1.23956377069161 0.121665739947057 no 2984 0.107568393957685 4347 25236615 SGTC_2522 biochanin a 4.94 µM -1.23965199700487 0.121648894607401 no 2985 0.10755206968913 4334 5280373 A possible chelator. SGTC_1453 4237-0541 195 µM -1.23969103105919 0.121641442230288 no 2986 0.107544847896647 4320 739892 SGTC_2338 7999974 200 µM -1.24055264049461 0.121477025555823 no 2987 0.107385528260191 4313 315925 SGTC_1333 1482-0047 286 µM -1.24152331817832 0.121291983141243 no 2988 0.107206244764914 4323 3811116 SGTC_1094 duloxetine 25.4 µM -1.24367380288038 0.120882737772848 no 2989 0.106809820696207 4342 60834 A selective serotonin reuptake inhibitor. SGTC_1329 1447-1697 50.6 µM -1.24544673233505 0.120546074150218 no 2990 0.106483792155591 4320 2840515 SGTC_222 nsc-310342 10.666 µM -1.24755038887446 0.120147465522766 no 2991 0.106097878151654 4346 432556 SGTC_2130 NSC 7 2.4545 µM -1.24939546175002 0.119798619615227 no 2992 0.105760233749154 4398 21448 SGTC_3310 9130229 44.1445 µM -1.24962355566993 0.119755543800129 no 2993 0.105718547057396 4347 7761258 SGTC_1222 0366-0074 1.18 µM -1.25195888057819 0.119315143136142 no 2994 0.105292423831618 4347 286520 SGTC_761 k216-0224 480 µM -1.25451654038443 0.118834126823904 no 2995 0.10482715879053 4351 1340404 SGTC_2687 chenodiol 100 µM -1.25504695873816 0.118734543340468 no 2996 0.104730856808939 4389 5702181 A cholesterol synthesis inhibitor. SGTC_1883 5-benzylidenerhodanine 20 µM -1.25597597976112 0.118560266216567 no 2997 0.104562339523114 4313 1273210 SGTC_1357 1503-1303 39.5 µM -1.25789026322692 0.118201731694325 no 2998 0.104215722745742 4317 292895 SGTC_985 1493-0307 8.71 µM -1.26307247463627 0.117234981829654 no 2999 0.103281567498424 4357 3278274 SGTC_1211 1056-0033 32.3 µM -1.26615585073515 0.116662437648286 no 3000 0.102728645120865 4391 6741922 SGTC_286 k060-0067 22.9 µM -1.27195321899499 0.115591313699098 no 3001 0.101694870605793 4375 5985051 SGTC_2779 methotrexate 400 µM -1.2730677017418 0.115386204665656 no 3002 0.101497009413657 4353 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2279 7948423 32.93 µM -1.27532556490802 0.114971461407526 no 3003 0.101097016347484 4319 1247112 SGTC_2363 9053361 176 µM -1.27938316348767 0.114228794587295 no 3004 0.100381079895373 4400 6469797 YMR079W SEC14 SGTC_1451 4152-0210 104 µM -1.27974605451321 0.114162541055837 no 3005 0.100317230873703 4383 659563 SGTC_2300 7976697 71.57 µM -1.28133277641458 0.113873172450695 no 3006 0.100038402510636 4243 2236109 SGTC_1478 0453-0656 35.7 µM -1.28412915567309 0.113364473055171 no 3007 0.099548384057991 4354 5258496 SGTC_3074 9116018 49.47 µM -1.28989155854275 0.112321329723528 no 3008 0.098544156047178 4411 17027303 SGTC_938 3126-1755 342 µM -1.29012842660155 0.112278597756725 no 3009 0.0985030357499243 4353 1777771 SGTC_860 0443-0016 25.1 µM -1.29220127761793 0.111905142580098 no 3010 0.0981437246848613 4389 5337942 SGTC_36 0335-0881 14.2 µM -1.29375281927402 0.11162619095716 no 3011 0.0978754071682467 4268 23828853 SGTC_1387 3342-1166 1.8 µM -1.29563171985162 0.111289049946699 no 3012 0.0975511977643197 4335 3418228 SGTC_606 k015-0008 38.6 µM -1.29694865376253 0.111053180491949 no 3013 0.0973244271695634 4430 1970475 SGTC_2902 5787006 60.46 µM -1.29717958461905 0.111011856542145 no 3014 0.0972847017153232 4317 591003 SGTC_958 1222-0007 33 µM -1.29893237640697 0.110698562014038 no 3015 0.0969835687256435 4425 7312461 SGTC_1196 1588-0294 184 µM -1.29900260393304 0.110686022740385 no 3016 0.0969715177750992 4376 6144269 SGTC_713 1488-1073 324 µM -1.30541141165531 0.109545998167015 no 3017 0.0958763973190362 4399 3312542 SGTC_1198 1612-1005 86.7 µM -1.30773943011528 0.109133975766044 no 3018 0.0954808522641161 4442 6998509 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.30878869573354 0.108948636889537 no 3019 0.095302968583403 4424 368090 SGTC_292 k038-0015 474 µM -1.30916877337691 0.10888155706227 no 3020 0.0952385936474653 4365 46368540 SGTC_1443 4112-3303 14 µM -1.31065740216594 0.108619115165164 no 3021 0.0949867682239684 4412 704433 SGTC_611 3453-1652 23.7 µM -1.31520631495407 0.107819972319221 no 3022 0.0942202866997314 4390 1560575 SGTC_1937 st074714 47.2 µM -1.31734730520854 0.107445317096044 no 3023 0.0938611177021576 4316 17250970 SGTC_2684 capsaicin 100 µM -1.31889739804372 0.107174650155285 no 3024 0.0936017080773046 4412 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.3200124483515 0.10698025174246 no 3025 0.0934154309195719 4408 688664 SGTC_2048 5246248 200 µM -1.32196071883735 0.106641200021526 no 3026 0.093090615807254 4401 677046 SGTC_2839 9003951 25.97 µM -1.32326141456181 0.106415275973236 no 3027 0.0928742293256177 4430 2990634 SGTC_2719 novobiocin 32.65 µM -1.32697617114102 0.105771945635183 no 3028 0.0922582826309875 4434 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3145 9085516 49.47 µM -1.32901537260805 0.105419989464485 no 3029 0.0919214491163244 4370 25236195 SGTC_1980 st071811 45.7 µM -1.32907036557829 0.105410509692216 no 3030 0.091912378054237 4454 4974850 SGTC_352 k048-0007 5.11 µM -1.33050948437718 0.10516265136188 no 3031 0.0916752317730687 4324 6811911 SGTC_1843 st055809 45.5 µM -1.33224481085298 0.104864338646176 no 3032 0.091389877961531 4437 16413835 SGTC_1561 5-methoxyflavone 52.9 µM -1.33384686026982 0.104589481384234 no 3033 0.0911270249658419 4352 94525 SGTC_310 1273-0058 1.06 µM -1.33550269075703 0.104305945945908 no 3034 0.0908559376019884 4153 2734232 SGTC_1316 1272-0050 65.9 µM -1.33818158091125 0.103848407709033 no 3035 0.0904186259426054 4364 7340392 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.34063441928509 0.103430755988471 no 3036 0.0900195882327317 4413 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_314 1671-0008 2.74 µM -1.34179209505239 0.103234059330193 no 3037 0.0898317080119958 4278 3913060 SGTC_2171 5739187 198.077 µM -1.34180321991085 0.103232170462728 no 3038 0.0898299039638757 4342 2262761 SGTC_374 0880-0231 82.3 µM -1.3422855214897 0.103150305568073 no 3039 0.0897517180478979 4261 6833587 SGTC_2844 9010103 25.97 µM -1.34655221053489 0.102428139078579 no 3040 0.0890622471823886 4386 2480525 SGTC_2341 7987486 176.74 µM -1.34952939231117 0.101926412803193 no 3041 0.0885834930429373 4425 1258686 SGTC_856 0433-0016 11.3 µM -1.354254001893 0.101133878494591 no 3042 0.0878276778711535 4437 3911780 SGTC_3100 9120536 49.47 µM -1.3569146339263 0.100689549646432 no 3043 0.0874041682328884 4288 16421196 SGTC_605 1315-0399 119 µM -1.35992659744312 0.100188268195868 no 3044 0.0869265766309719 4480 24020461 SGTC_2336 9001819 198.65 µM -1.36046031360292 0.100099632092594 no 3045 0.0868421517192741 4444 2989602 SGTC_398 bronopol 33.3 µM -1.3610472663351 0.100002220924454 no 3046 0.0867493764292765 4336 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2759 disulfiram 3.38 µM -1.36334180414688 0.0996220817343735 no 3047 0.0863874064089668 4322 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3311 9131146 2.8755 µM -1.36470355825731 0.0993969779514406 no 3048 0.086173120417698 4355 4900406 YPR165W RHO1 SGTC_2284 7945075 39.21 µM -1.3647268689674 0.0993931278308498 no 3049 0.0861694557026777 4364 1245402 SGTC_1234 0326-0494 15.5 µM -1.36843120243882 0.098782684822945 no 3050 0.0855885714859828 4477 1547813 SGTC_872 0588-0139 234 µM -1.3733831785828 0.0979709323098767 no 3051 0.0848166281875415 4386 2047100 SGTC_220 paclitaxel 373.376 µM -1.37555065517839 0.0976171709720171 no 3052 0.0844803963553623 4389 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_999 SEC7.066 22.7 µM -1.38132943202656 0.0966785762986064 no 3053 0.0835888463173505 4371 740511 YDR170C SEC7 SGTC_2451 5856223 45.7 µM -1.38317694427583 0.0963799043651588 no 3054 0.0833053086609333 4416 2179896 SGTC_2139 5578692 56.4705 µM -1.38354216086094 0.0963209431921489 no 3055 0.083249344572475 4403 650991 YMR113W FOL3 SGTC_2172 5754775 163.918 µM -1.3838458161864 0.09627194075805 no 3056 0.0832028353696277 4413 2263357 SGTC_2106 5357045 167.29 µM -1.38505076178142 0.0960776730527789 no 3057 0.0830184730987567 4448 668842 SGTC_2894 9048625 32.47 µM -1.38713575248291 0.0957422009523944 no 3058 0.0827001859211671 4443 4092861 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.39240282310392 0.0948985762273404 no 3059 0.0819002250347979 4421 1377 SGTC_2251 lansoprazole 556 µM -1.39290755873845 0.0948180213789672 no 3060 0.0818238732023063 4391 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_709 3807-1509 243 µM -1.39294179895657 0.0948125585307568 no 3061 0.0818186955961987 4506 1886677 YPL242C IQG1 SGTC_1436 4092-1007 8.32 µM -1.39468028807147 0.094535496401638 no 3062 0.081556135849337 4424 2881121 SGTC_1008 4106-0037 6 µM -1.39508066789667 0.0944717727184692 no 3063 0.0814957575740991 4449 2905394 SGTC_1839 st053978 48 µM -1.39671111259615 0.0942126013497394 no 3064 0.0812502305590752 4470 3788398 SGTC_525 k781-2675 26.7 µM -1.39731998859138 0.0941159505816484 no 3065 0.0811586837987217 4380 3651118 YDL195W SEC31 SGTC_1779 st039427 55 µM -1.39850610180405 0.0939278813559316 no 3066 0.0809805708104771 4421 1124498 SGTC_774 k060-0086 136 µM -1.39896643058453 0.0938549667249315 no 3067 0.0809115249534538 4425 5911235 SGTC_1040 k898-0338 155 µM -1.39962764100263 0.0937503061906861 no 3068 0.0808124261359179 4426 20969351 SGTC_707 0865-0008 204 µM -1.40169587784137 0.0934234889621447 no 3069 0.080503041057143 4471 723043 SGTC_2931 9014674 55.67 µM -1.40289319136127 0.0932346777126948 no 3070 0.0803243457543687 4395 2996810 SGTC_1650 st011916 45.8 µM -1.40308412633136 0.0932045941656561 no 3071 0.0802958770389655 4382 242528 SGTC_1952 st077036 64.1 µM -1.40548669367643 0.0928266605529391 no 3072 0.0799383016865529 4448 2937007 SGTC_1269 0831-0796 3.05 µM -1.40759495488728 0.092495956975278 no 3073 0.0796255211076464 4459 927758 SGTC_1815 st051655 58.2 µM -1.41019090740557 0.0920899521923598 no 3074 0.0792416599629004 4380 5984156 SGTC_2162 5663267 200 µM -1.41065077494191 0.0920181670799075 no 3075 0.079173806088679 4441 6456493 SGTC_2119 5528445 120.635 µM -1.4194792350526 0.0906480710971819 no 3076 0.0778796732548154 4474 791935 SGTC_2564 betulinic acid 100 µM -1.42300817622035 0.0901046682093225 no 3077 0.0773668925319006 4470 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_83 0170-0301 39.027 µM -1.42337494545191 0.0900483304967807 no 3078 0.0773137457680111 4464 3089716 SGTC_2492 derrusnin 100 µM -1.43128909702448 0.0888390420085622 no 3079 0.0761736887013602 4480 1715307 Part of coumarin class of compounds. SGTC_521 r062-0005 13.8 µM -1.43278922265885 0.0886111912495454 no 3080 0.0759590410983829 4380 2832033 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.43847312979755 0.0877518237706302 no 3081 0.0751499280790925 4468 5024745 SGTC_1181 1222-0449 220 µM -1.44402883949727 0.0869178623324955 no 3082 0.074365431584031 4513 658318 SGTC_3223 9129970 49.47 µM -1.44445159215791 0.0868546466433223 no 3083 0.0743059935778906 4483 17248386 SGTC_1852 st056254 31.4 µM -1.44594941689126 0.086630948107825 no 3084 0.0740956949672319 4425 442583 SGTC_2998 9066762 71.4286 µM -1.45763932349249 0.0848998483034841 no 3085 0.0724699923322695 4490 4945196 SGTC_2055 5235184 200 µM -1.45944301961726 0.084635073608023 no 3086 0.0722216064071639 4487 2836034 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.46038508646093 0.0844970287687147 no 3087 0.0720921345913609 4494 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2220 6782180 200 µM -1.46223166389432 0.0842269325175261 no 3088 0.0718388687450286 4418 833803 SGTC_459 nigericin 15.3 µM -1.4641154558541 0.0839520612101062 no 3089 0.071581202473441 4504 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1036 k216-0215 33.5 µM -1.46598748227428 0.0836795745043129 no 3090 0.0713258485543307 4434 622330 SGTC_810 3825-7150 143 µM -1.46793696246641 0.0833965206624397 no 3091 0.0710606733870654 4503 22330411 YGL099W LSG1 SGTC_3234 9132280 49.47 µM -1.47016577785607 0.0830737913040805 no 3092 0.0707584304110208 4496 17612295 SGTC_2485 5633444 17.78 µM -1.47191143075931 0.0828216798058918 no 3093 0.0705223982082481 4453 5724239 SGTC_1989 st071868 50.2 µM -1.47295672430851 0.0826709917382004 no 3094 0.0703813525723438 4462 16414057 SGTC_1772 st048439 82.2 µM -1.4805686226847 0.0815798873301949 no 3095 0.0693607809141621 4518 2927068 YDL195W SEC31 SGTC_2198 6589944 200 µM -1.4823514110488 0.0813259154201892 no 3096 0.069123407699361 4495 5290268 SGTC_2490 carminic acid 95.39 µM -1.4858920213328 0.0808232974322877 no 3097 0.0686538421760848 4470 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2823 7987624 58.44 µM -1.48671582916384 0.0807066883520369 no 3098 0.0685449400982647 4439 2239440 SGTC_3216 9129716 49.47 µM -1.49135901671893 0.0800518252433806 no 3099 0.0679336310007196 4400 8056934 SGTC_1744 st037937 38.9 µM -1.49177367517206 0.079993538860129 no 3100 0.0678792436517971 4519 1016152 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.49346397211733 0.0797562745720754 no 3101 0.0676578891191247 4497 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_80 0159-0065 512.242 µM -1.49943396179107 0.078922535934707 no 3102 0.0668805443046325 4449 1548079 SGTC_1282 0886-0010 32.4 µM -1.50001916344177 0.0788411662570576 no 3103 0.0668047193016277 4512 2836211 YNL267W PIK1 SGTC_2222 6885208 172.143 µM -1.50260392574655 0.0784825267892969 no 3104 0.0664706052288667 4513 609514 SGTC_568 1193-0097 7.48 µM -1.50536881160161 0.0781002654160484 no 3105 0.0661146414427756 4292 3646150 SGTC_2934 9036370 36.88 µM -1.52078784297961 0.0759943532240525 no 3106 0.0641565430833346 4472 6462800 SGTC_3333 9141820 12.094 µM -1.52213474346962 0.0758124685805602 no 3107 0.0639876610183143 4491 1939433 SGTC_2216 7189485 200 µM -1.52521176729744 0.0753981932282849 no 3108 0.0636031432448634 4524 731273 SGTC_1878 temozolomide 1 mM -1.52948998200025 0.0748250655833253 no 3109 0.063071510345628 4470 5394 DNA alkylating agent. SGTC_719 2810-4230 27.3 µM -1.52955135486764 0.0748168680658944 no 3110 0.0630639090966895 4526 721079 SGTC_1464 k208-0027 110 µM -1.53369415372118 0.0742651009292888 no 3111 0.0625524563555217 4507 X1464 SGTC_887 0885-0007 9.62 µM -1.53432114002019 0.0741818659232956 no 3112 0.0624753337490488 4530 5719458 SGTC_82 0054-0107 293.755 µM -1.537232287734 0.0737963323087864 no 3113 0.0621182181361966 4481 3104697 SGTC_2141 5621638 7.665 µM -1.54986176930962 0.0721414790319979 no 3114 0.0605873487063023 4532 2856238 SGTC_1587 estradiol valerate 56.1 µM -1.55116140366688 0.0719728138584195 no 3115 0.060431504517884 4565 13791 A steroid. SGTC_1223 0764-0573 147 µM -1.55362176096239 0.0716543395032835 no 3116 0.0601373327414083 4516 1609797 SGTC_3250 9135583 49.47 µM -1.55517387458495 0.0714539871518317 no 3117 0.0599523322965949 4537 7699353 SGTC_345 1362-0200 395 µM -1.56362231465025 0.0703709635089571 no 3118 0.0589531456330143 4514 1419823 SGTC_2088 5278280 127.392 µM -1.56703810179377 0.0699366867292096 no 3119 0.0585528929389516 4564 791502 SGTC_2702 st077768 96.8 µM -1.5670464437876 0.0699356286738403 no 3120 0.058551918064925 4491 6484119 SGTC_1519 esterone 74 µM -1.567480583694 0.069880581611539 no 3121 0.0585012005727397 4520 698 A steroid. SGTC_2904 7225135 42.03 µM -1.57010372081955 0.0695486882853745 no 3122 0.0581954915529446 4584 4446116 SGTC_1240 0356-0016 42.1 µM -1.57151815893222 0.0693702304171501 no 3123 0.0580311699136436 4495 4305613 SGTC_1514 1189-1591 158 µM -1.57175292815494 0.0693406440411172 no 3124 0.0580039310345819 4539 767698 YMR146C TIF34 SGTC_2108 5365811 200 µM -1.57212789501131 0.0692934096673134 no 3125 0.0579604466983922 4527 780283 SGTC_1113 artemisinin 1.17947 µM -1.57232458437324 0.0692686427268653 no 3126 0.0579376471794658 4561 2240 An anti-malaria and mitochondrial poison. SGTC_1924 st058459 75.1 µM -1.57330584623224 0.0691451850177072 no 3127 0.0578240081484905 4500 688683 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.5751968859651 0.0689077416848353 no 3128 0.0576055028889809 4536 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_690 glyoxal 20.3 µM -1.58250645343316 0.0679958423147125 no 3129 0.0567670001282734 4342 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_646 4092-0839 27.3 µM -1.59138720653408 0.0669005008251357 no 3130 0.0557612308517934 4561 877796 SGTC_1581 himbacine 57.9 µM -1.59279421270157 0.0667282220380412 no 3131 0.0556031819294621 4546 5281825 An alkaloid muscarinic receptor antagonist. SGTC_995 3931-2021 34.6 µM -1.59386731558194 0.0665970584646896 no 3132 0.0554828781911116 4550 730143 SGTC_2805 7950783 58.44 µM -1.59725324884138 0.0661845094672212 no 3133 0.0551046337145729 4545 1178958 YDL195W SEC31 SGTC_1679 SEC14.276 6.7 µM -1.60301687769576 0.0654868133825112 no 3134 0.0544654639565798 4508 1005053 YMR079W SEC14 SGTC_3258 9138477 49.47 µM -1.60902844064653 0.0647651957549387 no 3135 0.0538050614509882 4576 4970355 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.61682503817877 0.0638385209409702 no 3136 0.0529580265548816 4583 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2826 7992541 19.48 µM -1.61785437564875 0.0637169522197221 no 3137 0.0528469923489282 4543 2985066 SGTC_3269 9137823 49.47 µM -1.61849779701162 0.0636410532002254 no 3138 0.0527776806027832 4500 17682936 SGTC_1251 0490-5699 265 µM -1.62009873226619 0.0634525095651466 no 3139 0.0526055348570958 4558 3883818 SGTC_2002 4023503 131 µM -1.62930400034121 0.0623768212379889 no 3140 0.0516243398664217 4544 4736863 YCR052W RSC6 SGTC_3009 9080819 71.4286 µM -1.63131813604653 0.0621433649868721 no 3141 0.0514116042601648 4563 17027216 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.64996053015724 0.0600147737399967 no 3142 0.0494755045455773 4506 5711223 A potent inhibitor of glutathione S-transferases. SGTC_675 1309-0189 238 µM -1.65057790238236 0.059945271231216 no 3143 0.0494123970611116 4569 4246530 SGTC_1265 0819-1001 68.8 µM -1.65436253724601 0.059520581543268 no 3144 0.0490269367328465 4514 3106768 SGTC_2676 harmalol 100 µM -1.66118681581269 0.058760764454083 no 3145 0.0483379663185783 4535 5459187 A monoamine oxidase inhibitor SGTC_3056 9094900 49.47 µM -1.66547267522158 0.0582874810830577 no 3146 0.0479092453558147 4568 25236784 SGTC_2871 9038510 12.99 µM -1.67519473312881 0.0572249852198061 no 3147 0.0469480153037334 4527 4945164 SGTC_586 0957-0265 8.15 µM -1.67570688639915 0.0571694389074327 no 3148 0.0468978101485189 4502 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1372 2752-0194 270 µM -1.67642915101684 0.0570911768037226 no 3149 0.0468270814731624 4514 823334 SGTC_993 3909-8757 62.7 µM -1.67728513429646 0.0569985346393446 no 3150 0.0467433690470616 4542 4288324 YLR208W SEC13 SGTC_1377 2944-0135 198 µM -1.67983994500527 0.0567227338836227 no 3151 0.0464942304703429 4583 1894137 SGTC_3188 9110789 49.47 µM -1.68128353308055 0.0565673589504923 no 3152 0.0463539274158306 4547 849217 SGTC_1608 st001473 40.5 µM -1.68596565313094 0.056065724156271 no 3153 0.0459012075457494 4555 7292267 SGTC_1491 4138-0063 26.5 µM -1.68707052014362 0.055947863618034 no 3154 0.0457948963939572 4610 23883227 SGTC_1055 3448-0672 86 µM -1.69278752710677 0.0553411269405725 no 3155 0.0452479588421792 4550 748378 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.69578153779425 0.0550254570488807 no 3156 0.0449636300573457 4605 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2714 st079313 56.9 µM -1.6963823377945 0.0549622841520422 no 3157 0.0449067481893451 4576 2939799 SGTC_2600 tangeritin 87.95 µM -1.69641450883362 0.0549589030500789 no 3158 0.0449037039705864 4507 68077 A bioactive flavone. SGTC_2924 9010168 62.78 µM -1.69816861603816 0.0547747991045966 no 3159 0.0447379710343341 4580 2993929 SGTC_393 acivicin 6.25 µM -1.70302996177344 0.0542671192031364 no 3160 0.0442812307434891 4452 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2132 5317594 122.667 µM -1.70439134300527 0.0541256167951626 no 3161 0.0441540000789622 4527 794577 SGTC_2804 7954240 19.48 µM -1.7177091607301 0.0527567107051772 no 3162 0.0429248388026706 4598 828705 SGTC_346 4513-0042 7.16 µM -1.72362772080784 0.0521572396262354 no 3163 0.0423875354405284 4555 2827372 SGTC_1977 st070720 65.3 µM -1.73820391111091 0.0507039269161033 no 3164 0.0410874451029103 4624 682188 SGTC_2188 6126565 140.678 µM -1.74083351053923 0.0504452106605942 no 3165 0.04085638307749 4525 874518 SGTC_1085 doxorubicin 7.67 µM -1.74554793826025 0.0499840103036222 no 3166 0.040444767760088 4616 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1168 k815-0004 80.5 µM -1.74556673135851 0.0499821785745681 no 3167 0.0404431337029711 4607 642433 SGTC_2036 5160441 105 µM -1.74969510415992 0.0495810893355832 no 3168 0.0400854694781694 4581 134534 YIL048W NEO1 SGTC_1818 st052136 56.3 µM -1.75077239734671 0.0494768493470898 no 3169 0.0399925615167485 4275 674169 SGTC_984 1492-0255 2.91 µM -1.75299672699552 0.0492621744293536 no 3170 0.0398012844474461 4572 1585198 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.75365803008582 0.0491984942563853 no 3171 0.0397445605652865 4600 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1494 4358-1428 177 µM -1.75425573069438 0.049140995259047 no 3172 0.0396933488099264 4633 1564571 SGTC_1643 st009866 20.2 µM -1.75679825066151 0.0488970035023533 no 3173 0.0394761016912636 4600 3156273 YOR207C RET1 SGTC_2971 9092186 9.93 µM -1.75685001763446 0.0488920457822377 no 3174 0.0394716884989601 4569 25236400 SGTC_893 0958-0369 48.9 µM -1.75770336756798 0.048810378376044 no 3175 0.0393989972834688 4476 6819948 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.75885235504447 0.0487005900831057 no 3176 0.0393012947547333 4556 17037758 SGTC_754 3474-0146 171 µM -1.76733843122437 0.0478958272847184 no 3177 0.0385857836539034 4596 24762078 SGTC_3014 9081533 49.47 µM -1.77346182749766 0.0473217649279064 no 3178 0.0380761059053253 4622 21367265 SGTC_299 1273-0059 1.44 µM -1.77869920538753 0.0468351526286667 no 3179 0.0376445447714343 4376 2848077 SGTC_2468 5987765 72.9 µM -1.7841518070507 0.0463328164646743 no 3180 0.0371995004458322 4655 26772094 SGTC_2968 9090663 33.37 µM -1.79166999875696 0.0456472863239449 no 3181 0.0365929215127228 4556 25236811 SGTC_1218 1348-1416 30.7 µM -1.79189511391397 0.0456268860985474 no 3182 0.0365748844048002 4600 6787668 SGTC_3037 9091026 49.47 µM -1.79541991831989 0.0453084186416851 no 3183 0.0362934106533177 4504 25236398 YIL048W NEO1 SGTC_2328 6201408 200 µM -1.79738266710781 0.045131860063854 no 3184 0.0361374452460185 4557 2890418 SGTC_2225 6654152 15.4 µM -1.79838617751649 0.0450418036636214 no 3185 0.0360579158350107 4583 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_953 1188-0045 9.7 µM -1.8042466788399 0.0445187590734567 no 3186 0.035596322317803 4595 6144426 SGTC_2247 cerulenin 830 nM -1.80435693515457 0.0445089658902275 no 3187 0.035587684787035 4634 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_44 0929-0055 61.211 µM -1.80506724237801 0.0444459166022729 no 3188 0.035532080169996 4481 1379590 SGTC_2305 7443522 69.23 µM -1.81089681093036 0.0439311789724697 no 3189 0.0350784131708271 4535 5415886 SGTC_2259 7964009 200 µM -1.81108196894689 0.0439149090546808 no 3190 0.0350640821025302 4635 313134 SGTC_1546 5-methoxyflavanone 78.7 µM -1.81498664921855 0.0435729335307432 no 3191 0.0347629806080038 4658 147795 SGTC_2989 9073649 71.4286 µM -1.82023676148266 0.0431165150013668 no 3192 0.0343614785352669 4584 21367202 SGTC_874 0599-0792 117 µM -1.82608118945023 0.0426129802033143 no 3193 0.0339190165943766 4617 765305 SGTC_2582 agaric acid 100 µM -1.82947182992908 0.0423230410421726 no 3194 0.0336644778102713 4284 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.84394606905433 0.0411032251257952 no 3195 0.0325955001220021 4593 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1030 k029-0042 36.7 µM -1.84471657100321 0.0410390987194964 no 3196 0.0325393895243403 4628 6080581 SGTC_1376 2910-0861 41.3 µM -1.84643385734922 0.0408964664099552 no 3197 0.0324146174777769 4588 1112859 SGTC_160 3453-0671 289.699 µM -1.84864008636403 0.0407138145515999 no 3198 0.0322549001527755 4624 5322268 SGTC_2625 euphol 100 µM -1.86656823240956 0.039253983697531 no 3199 0.0309809536523297 4643 6708538 A triterpene alcohol. SGTC_1719 st032227 49.2 µM -1.87022491326925 0.038961525748561 no 3200 0.0307262957400924 4639 3125804 SGTC_2835 9006588 71.43 µM -1.87079886093757 0.0389157834539806 no 3201 0.0306864827850384 4592 2345538 SGTC_2326 6164455 177.58 µM -1.87883010959129 0.0382802872696432 no 3202 0.0301338471800876 4570 2888790 SGTC_2697 mebhydrolin 72.4 µM -1.87889218863095 0.0382754082385577 no 3203 0.0301296078287771 4654 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_122 0236-0016 402.397 µM -1.88563617309366 0.0377483844524546 no 3204 0.0296719996750899 4638 6808838 SGTC_426 0988-0037 14.6 µM -1.8861260768386 0.0377103317307368 no 3205 0.029638983532326 4637 5383008 SGTC_2217 6934799 96.0675 µM -1.89296430123094 0.0371824418980138 no 3206 0.0291813085213001 4636 675606 SGTC_1481 3346-2004 36 µM -1.89438222405172 0.0370737420059464 no 3207 0.0290871470820501 4726 2770522 SGTC_931 2812-0076 566 µM -1.89895484972401 0.0367249664149165 no 3208 0.0287852063264967 4601 3450959 SGTC_1983 st071813 46.9 µM -1.90382224592378 0.0363566606852717 no 3209 0.0284666691297667 4696 11838595 SGTC_2769 toremifene 3.73 µM -1.91438234069002 0.0355679907288992 no 3210 0.027785660142484 4647 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1483 3453-0561 55.9 µM -1.91478652790622 0.0355380853089721 no 3211 0.0277598666331526 4692 4546991 SGTC_1708 st033234 31.827 µM -1.91577189574553 0.0354652652777184 no 3212 0.0276970682480949 4712 674664 SGTC_2089 5281248 129.67 µM -1.91742071789323 0.0353436887401811 no 3213 0.027592252132999 4650 2737878 SGTC_942 3253-1115 227 µM -1.92044253636264 0.035121761125158 no 3214 0.0274010125001547 4668 46497897 SGTC_254 nsc-64875 3.808 µM -1.92136107448569 0.0350545291313742 no 3215 0.0273431011672453 4658 56993 SGTC_3344 9148862 3.898 µM -1.92240149641241 0.0349785035090377 no 3216 0.0272776287227605 4686 4905352 SGTC_2386 9075165 157.42 µM -1.92453258567106 0.034823203198654 no 3217 0.0271439301558032 4656 16452277 SGTC_2977 9011197 71.43 µM -1.92710020642038 0.0346368436154479 no 3218 0.026983571519165 4686 2704722 SGTC_1606 st000094 49.2 µM -1.93137337584552 0.0343285106871589 no 3219 0.0267184476030603 4688 1242210 SGTC_2699 st077704 54.6 µM -1.93320610691929 0.0341969619285798 no 3220 0.0266054063808591 4657 645852 SGTC_1800 st050079 29.0735 µM -1.95019583436471 0.0329971028668139 no 3221 0.0255763910584112 4510 3645560 SGTC_1917 st066507 28.5 µM -1.9509107351824 0.0329473851417516 no 3222 0.0255338326995069 4581 3156428 SGTC_2976 9009005 19.48 µM -1.96240260355387 0.0321566218031153 no 3223 0.0248578149475094 4638 2993148 SGTC_657 3534-0529 86.7 µM -1.96274092121218 0.0321335814403872 no 3224 0.0248381428199193 4684 1049549 SGTC_1981 st071826 47 µM -1.96855462234313 0.0317397771832867 no 3225 0.0245021288980604 4697 11838600 SGTC_2092 5303694 80.6725 µM -1.9785172493764 0.0310742111820455 no 3226 0.0239351923055684 4700 1963699 SGTC_2380 9035439 200 µM -1.98900416791928 0.0303861366808458 no 3227 0.0233503714626306 4708 6462575 SGTC_2544 sphondin 68.51 µM -1.99228944748759 0.0301731955134607 no 3228 0.0231696544260028 4639 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_307 1501-1223 22.3 µM -1.99485763607826 0.0300075966151185 no 3229 0.023029204552655 4690 2830329 SGTC_2306 7482397 179.52 µM -1.99985228376109 0.0296876955826455 no 3230 0.0227581084688625 4662 891448 SGTC_248 streptozotocin 5.23457 mM -2.00344104775063 0.0294595910849545 no 3231 0.0225649846517671 4709 5300 DNA alkylating agent. SGTC_1516 st013856 110 µM -2.0053210642346 0.0293406778056131 no 3232 0.0224643671691306 4682 5281404 A mutagen and neurotoxin. SGTC_2900 5328528 85.29 µM -2.00750811710196 0.0292028459407718 no 3233 0.0223477936069405 4667 795359 SGTC_329 k048-0121 21.3 µM -2.02004098032996 0.0284233372576617 no 3234 0.0216895684691295 4696 6832902 SGTC_1856 st057054 55.7 µM -2.02542150465569 0.0280940361936708 no 3235 0.0214120505615604 4667 1266018 SGTC_73 0327-0325 16.231 µM -2.02770588531578 0.0279551904171953 no 3236 0.0212951373172521 4525 53298 SGTC_2716 st080858 38.6235 µM -2.04589274757824 0.0268700474054511 no 3237 0.0203834620235383 4677 5296050 SGTC_2280 7785178 200 µM -2.05151272886455 0.0265419224442707 no 3238 0.0201085206651923 4685 2954328 SGTC_1603 st002045 67.8 µM -2.05227333652228 0.0264977723258946 no 3239 0.0200715528860659 4702 5887985 SGTC_617 3770-0098 35 µM -2.05461610423716 0.0263621698048495 no 3240 0.0199580494754295 4642 5962639 SGTC_2611 pyromycin 23.93 µM -2.05774284656556 0.0261820938624011 no 3241 0.0198074125135527 4640 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1006 4099-6547 255 µM -2.06302304986956 0.0258803307725562 no 3242 0.0195552191344733 4710 3146833 SGTC_2507 purpurin 79.67 µM -2.07031236994981 0.025468533249128 no 3243 0.0192115509711273 4679 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2709 st078560 56 µM -2.07435718781651 0.0252424052490909 no 3244 0.0190230751372384 4673 17250903 SGTC_829 1635-0120 117 µM -2.0745659781539 0.0252307785052959 no 3245 0.0190133889911993 4691 285054 SGTC_2297 7971671 152.32 µM -2.07533984284658 0.0251877240412557 no 3246 0.0189775246399212 4671 909016 SGTC_2441 5730946 39.09 µM -2.08563501422153 0.0246207796848599 no 3247 0.0185058485680782 4705 1774275 SGTC_2917 7979103 53.79 µM -2.09014391477625 0.0243758722963818 no 3248 0.0183024369242856 4686 2980565 SGTC_2757 clomiphene 4.22 µM -2.09898311577003 0.0239016910746573 no 3249 0.0179091945696999 4679 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2686 alizarin 95.37 µM -2.10015057580336 0.0238396458647601 no 3250 0.0178577987445373 4681 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_298 1391-0729 10 µM -2.10536386171038 0.0235642330700719 no 3251 0.0176298235084842 4676 3237558 SGTC_1572 epiandrosterone 68.9 µM -2.10589157346277 0.0235365043410779 no 3252 0.0176068859041315 4688 441302 A steroid. SGTC_2883 9059145 45.46 µM -2.10990379942249 0.0233265774271284 no 3253 0.0174333214686428 4707 16476510 SGTC_2514 salinomycin 42.74 µM -2.11628154536017 0.0229961264975585 no 3254 0.0171604346757472 4686 23682228 A polyether potassium ionophore. SGTC_128 0906-2981 13.371 µM -2.1200455233413 0.0228029595962392 no 3255 0.0170011031981791 4704 6740226 SGTC_2414 st077232 92.9 µM -2.12348787301694 0.0226274973898958 no 3256 0.0168564953190302 4657 729801 SGTC_1602 st001878 87.6 µM -2.1296045790038 0.0223185266323729 no 3257 0.016602136352063 4692 595405 YLR310C CDC25 SGTC_2038 4100038 30.985 µM -2.1300108770269 0.0222981301288797 no 3258 0.0165853576902433 4674 3596803 SGTC_2033 5192550 145 µM -2.13575650062594 0.0220113745086211 no 3259 0.0163496332104576 4711 182073 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.14040840246816 0.0217814913815973 no 3260 0.0161608880372274 4715 688751 SGTC_1430 4049-0248 69.1 µM -2.14808806603946 0.0214064234287469 no 3261 0.0158533800436624 4724 22774488 SGTC_2930 9013230 14.89 µM -2.16046944280419 0.0208132305397743 no 3262 0.0153681733388781 4679 2995857 SGTC_2448 5185112 27.17 µM -2.16083850400877 0.0207957645557772 no 3263 0.0153539083074535 4709 5718189 SGTC_119 0121-0043 24.815 µM -2.17083166483641 0.0203275296727229 no 3264 0.0149719497026126 4706 1092378 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.17362947976274 0.020198049005753 no 3265 0.0148664863147644 4708 688761 SGTC_3268 9137683 49.47 µM -2.17477207750117 0.0201453719603943 no 3266 0.0148236002550987 4749 1953228 SGTC_2166 5933061 31.504 µM -2.17756712582527 0.0200170030649026 no 3267 0.0147191396213247 4673 2877375 SGTC_2952 9073731 13.78 µM -2.18778100774322 0.0195537925482351 no 3268 0.0143427789809068 4696 16457353 SGTC_2824 7998404 51.95 µM -2.21041559747096 0.0185596434396236 no 3269 0.0135381661452551 4705 837851 SGTC_2117 5521686 200 µM -2.2134671709699 0.0184289632268651 no 3270 0.0134327270730529 4726 803312 SGTC_1569 carminic acid 40.6 µM -2.22524581622452 0.017931881407818 no 3271 0.0130323703398155 4744 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_783 0848-0141 92.7 µM -2.23440971866415 0.0175530973826835 no 3272 0.0127280634109173 4702 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2085 5307070 144.047 µM -2.23841257694166 0.0173897974805153 no 3273 0.0125970813097464 4689 2840351 SGTC_701 4424-0219 185 µM -2.24377939685796 0.0171728908231393 no 3274 0.0124232993339734 4740 2911779 SGTC_1636 st007707 68.9 µM -2.2457954808116 0.0170920077713193 no 3275 0.0123585554590673 4732 403051 SGTC_215 1287-0124 461.5 µM -2.28117651180987 0.0157246801123397 no 3276 0.0112690020293873 4759 5560863 SGTC_2795 7780010 54.55 µM -2.28296574232766 0.0156581002966506 no 3277 0.011216193187237 4702 953673 SGTC_1951 sophoraflavanone G 9.2 µM -2.28479089803124 0.0155904330002308 no 3278 0.0111625458121801 4684 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1616 st002734 56.1 µM -2.30776098415623 0.0147600465182304 no 3279 0.0105062170369077 4732 4026101 SGTC_3342 9147791 14.508 µM -2.31213488963486 0.0146063142369468 no 3280 0.0103851254981044 4717 1838168 SGTC_531 3788-1495 174 µM -2.32052745372756 0.0143151912102946 no 3281 0.0101561807738713 4734 2896655 SGTC_162 k030-0015 37.8 µM -2.32652966127259 0.0141100628255768 no 3282 0.00999515600521114 4743 1809920 YMR134W ERG29 SGTC_1716 st033144 30.6155 µM -2.32850525011497 0.0140431024851383 no 3283 0.00994264539687044 4706 674617 SGTC_3182 9108849 49.47 µM -2.33018607390823 0.013986348679377 no 3284 0.00989815934554995 4730 17133045 SGTC_746 1095-0025 46.6 µM -2.33035275422977 0.0139807314306223 no 3285 0.00989375733475031 4747 6749286 SGTC_2731 amoxapine 43.43 µM -2.34297972637112 0.0135608091406053 no 3286 0.00956521129234113 4797 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1097 itavastatin 7.23 µM -2.35244627254319 0.0132531719860963 no 3287 0.00932519193956804 4762 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_806 3966-4455 5.86 µM -2.3590181748359 0.0130431652614949 no 3288 0.00916167916636102 4743 714982 SGTC_1330 1469-0054 61.8 µM -2.36419129297714 0.0128798863143195 no 3289 0.00903473986645048 4719 7102664 SGTC_1745 st081495 74 µM -2.37214637214536 0.0126322502251315 no 3290 0.00884254155700722 4647 13842402 YBL026W LSM2 SGTC_1384 3089-0840 101 µM -2.37616356917168 0.0125087711247486 no 3291 0.00874685303505812 4746 1069836 SGTC_640 3381-0960 37.1 µM -2.39000126985972 0.0120913991029619 no 3292 0.00842415727216831 4774 1745025 SGTC_395 anisomycin 6.25 µM -2.4167181460377 0.0113196263269091 no 3293 0.00783056939197678 4753 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1617 st002906 78 µM -2.42712442226022 0.0110308125147148 no 3294 0.00760951772666698 4746 5150859 SGTC_3293 9120939 62.045 µM -2.43045326598658 0.0109397877382345 no 3295 0.00753997534343086 4741 934087 SGTC_2583 asiatic acid 100 µM -2.43408378632674 0.0108412596051048 no 3296 0.00746476939447275 4727 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2942 9052777 62.25 µM -2.44949492765211 0.0104315680207345 no 3297 0.00715283623563825 4745 6469503 SGTC_2316 5844804 197.44 µM -2.45672183648455 0.0102441400168512 no 3298 0.00701056025521835 4747 776813 SGTC_396 dithiazanine 1.25 µM -2.46653567790523 0.00999432634156558 no 3299 0.00682135683009352 4748 10578 An antihelmenthic. SGTC_339 3091-4833 71.4 µM -2.47274078077308 0.00983913243628273 no 3300 0.00670406789384175 4604 3240077 SGTC_715 0868-0130 184 µM -2.47987429843809 0.00966332246644146 no 3301 0.00657143533547172 4781 2876258 SGTC_1707 st032323 6.317 µM -2.48878411865537 0.0094475947115371 no 3302 0.00640903863533637 4615 3132057 YMR211W DML1 SGTC_1884 5633444 25 µM -2.51675542848692 0.00879747218331909 no 3303 0.00592205067570684 4720 5724239 SGTC_1950 st077106 7.18 µM -2.51847087929695 0.00875890890330967 no 3304 0.00589328147735652 4718 13831864 SGTC_1563 conessine 56.1 µM -2.52539526600194 0.00860475128389106 no 3305 0.00577841117016068 4781 441082 An anti-amoebic, histamine inhibitor. SGTC_2736 butenafine 14.65 µM -2.53776592382838 0.00833526030401353 no 3306 0.00557812875539046 4733 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3125 9127534 49.47 µM -2.54487456092591 0.00818377762705462 no 3307 0.00546585001998959 4729 1639235 SGTC_1834 st055981 52.8 µM -2.54913962865965 0.00809405603204886 no 3308 0.00539945271975861 4741 471719 YDL150W RPC53 SGTC_2648 atorvastatin 78.68 µM -2.56753778095513 0.00771685912924187 no 3309 0.00512118136696065 4772 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2516 gossypol 71.55 µM -2.56767028643616 0.00771419959953098 no 3310 0.00511922441088232 4765 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2800 7887935 81.82 µM -2.56826033502452 0.00770236647222393 no 3311 0.00511051814035711 4755 2961002 SGTC_1929 genistein trimethyl ether 50.5 µM -2.57637960481712 0.0075411536848569 no 3312 0.00499204842241654 4759 136420 SGTC_331 k048-0133 24.5 µM -2.57654468539422 0.0075379069746856 no 3313 0.00498966528805156 4772 6813582 SGTC_2100 5377183 190 µM -2.58111901001931 0.00744843014434787 no 3314 0.00492403128587141 4776 2844202 SGTC_1548 st061468 90.8 µM -2.63420655984463 0.00647646821391605 no 3315 0.0042167082599513 4790 390799 SGTC_1477 0139-0234 16 µM -2.66079568606681 0.00603321790737705 no 3316 0.00389781227088682 4778 620880 SGTC_725 1497-0963 19 µM -2.66775796271747 0.00592168974932209 no 3317 0.00381796225368687 4784 3549977 SGTC_743 1275-0778 158 µM -2.71333843379154 0.00523565247294101 no 3318 0.00333045202578232 4773 2849257 YMR203W TOM40 SGTC_1736 st036774 51 µM -2.71335163142268 0.00523546453042034 no 3319 0.00333031937321062 4774 1272247 SGTC_344 k064-0035 6.43 µM -2.72770283411516 0.00503461169172015 no 3320 0.00318885170253077 4747 5088750 SGTC_431 k089-0097 107 µM -2.74451299933691 0.00480809292079758 no 3321 0.0030300377154673 4557 5499420 SGTC_618 k072-0232 33.2 µM -2.7687673534353 0.00449727235899293 no 3322 0.00281343993043099 4780 5872756 YGL099W LSG1 SGTC_533 1222-0222 6.71 µM -2.77176340092287 0.00446015041948958 no 3323 0.00278767722222508 4786 3982874 SGTC_1628 st004252 77.7 µM -2.77989102637028 0.00436082118254921 no 3324 0.00271885713627536 4775 692968 SGTC_3143 9086658 49.47 µM -2.79508817222619 0.00418038411595532 no 3325 0.00259427809332189 4738 25236626 SGTC_1833 st055984 71 µM -2.79981985268449 0.00412558402004761 no 3326 0.00255655663746726 4792 676288 SGTC_2372 9071633 200 µM -2.84793027677661 0.00360382902478028 no 3327 0.00220022820592546 4794 21321366 SGTC_537 1334-0398 209 µM -2.8532552354119 0.00354988351053606 no 3328 0.00216369247987692 4789 5846986 SGTC_514 4466-0038 2.65 nM -2.87196585273281 0.00336603419815332 no 3329 0.0020396352167391 4690 5722064 SGTC_513 4245-1575 41.7 µM -2.87976142033233 0.00329199488430577 no 3330 0.0019898810286181 4683 719745 SGTC_2427 5545055 42.75 µM -2.90148945581972 0.00309329799385723 no 3331 0.00185696639012785 4775 5372858 SGTC_3131 9127911 49.47 µM -2.92491667448079 0.00289121925408341 no 3332 0.00172274233854891 4764 45595681 SGTC_1814 st052110 31.539 µM -2.96784204122956 0.00255159127402947 no 3333 0.00149949202479305 4775 674163 SGTC_2723 salbutamol 83.58 µM -2.98146077756551 0.00245163212359507 no 3334 0.00143438396095306 4794 9884233 β2-adrenoceptor agonist SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -3.03440058897979 0.00209583428369712 no 3335 0.00120507085647041 4776 91467 include heat shock SGTC_173 1273-0061 2.693 µM -3.05045500889224 0.00199759227743998 no 3336 0.00114247455773314 4771 2847414 YPL266W DIM1 SGTC_304 1310-0298 97 µM -3.05641639455876 0.00196219042772908 no 3337 0.00111999970052675 4664 1550234 SGTC_3337 9144342 33.5465 µM -3.07558063493786 0.00185220919665255 no 3338 0.0010504655570415 4788 17682949 SGTC_2014 4013930 200 µM -3.0921833851124 0.00176149136841154 no 3339 0.000993450310428886 4777 64556 SGTC_171 k064-0041 9.68 µM -3.1141098936636 0.00164788055618015 no 3340 0.00092250378633508 4774 53325 SGTC_1859 st055998 20 µM -3.13806433625333 0.00153142303321883 no 3341 0.00085033771956901 4772 676301 SGTC_2442 5158906 48.48 µM -3.17939836039967 0.00134798345721698 no 3342 0.000737905581397146 4792 1893835 SGTC_1930 st074634 34.3 µM -3.2096535305963 0.00122669104778425 no 3343 0.000664475266059667 4767 684253 YOR116C RPO31 SGTC_2429 5902844 64.44 µM -3.24210096869603 0.00110777451837192 no 3344 0.000593259886412785 4793 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2925 9010536 32.5 µM -3.36886111034457 0.000737565264595069 yes 3345 0.000377397263166633 4784 2994177 SGTC_1785 bathophenanthroline 24 µM -3.48152078465787 0.00050805161846493 yes 3346 0.000249287543031792 4781 72812 An iron chelator. SGTC_2718 lomofungin 53.02 µM -3.52728617534147 0.000435335664382336 yes 3347 0.000209921358482146 4795 5351222 A RNA synthesis inhibitor. SGTC_3345 9148410 3.559 µM -3.56792617565717 0.000378977861725799 yes 3348 0.000179908921745227 4793 4903596 SGTC_2793 7325131 81.82 µM -3.57047682807249 0.000375677188088654 yes 3349 0.000178165988576509 4795 4176441 SGTC_2735 sertaconazole 140 nM -3.59559791495011 0.000344565615392001 yes 3350 0.00016182368266161 4808 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3266 9136860 49.47 µM -3.61722391124113 0.000319718592059248 yes 3351 0.000148889844662199 4708 4871271 YPR165W RHO1 SGTC_726 3448-4391 34.2 µM -3.73646220996914 0.000210127266567567 yes 3352 9.3313740762926e-05 4804 1356692 SGTC_2752 diclazuril 33.15 µM -3.79165306250649 0.000172324675030462 yes 3353 7.48239361994483e-05 4792 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1718 roemerine 11.9335 µM -3.86415445396579 0.000132281401251511 yes 3354 5.57373357832006e-05 4669 235224 An aporphine alkaloid with mutagenic activity. SGTC_2988 9073640 71.4286 µM -4.13014306671544 4.82606111705909e-05 yes 3355 1.81268777565642e-05 4803 9102229 SGTC_758 0868-0029 16 µM -9.79747067279342 1.05603613578783e-20 yes 3356 5.77200309761099e-23 4798 762687