SGTCid condition conc unit BTT1|YDR252W.score BTT1|YDR252W.strain.pval BTT1|YDR252W.strain.significant BTT1|YDR252W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_381 3461-2219 42.7 µM 5.97802097374482 2.59534838150788e-10 yes 1 1.12932330172218e-09 1 2883159
SGTC_248 streptozotocin 5.23457 mM 4.50440183868277 1.44960303455698e-06 yes 2 3.32800775414864e-06 17 5300 DNA alkylating agent.
SGTC_2568 diosmetin 100 µM 4.30095488598798 3.98740965088901e-06 yes 3 8.5031841977091e-06 20 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_457 grayanotoxin iii 135 µM 3.84153195042068 3.34321189082787e-05 yes 4 6.11344084729493e-05 75 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2516 gossypol 71.55 µM 3.69667753268981 6.24636497026744e-05 yes 5 0.000109219759836489 17 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_647 0140-0236 81 µM 3.66668672351733 7.09015661532138e-05 yes 6 0.000122856757602608 15 990837
SGTC_311 1315-0136 58 µM 3.46445562796761 0.000162636730390742 yes 7 0.00026565289127518 22 6759207
SGTC_2675 theaflavin digallate 100 µM 3.39061946959872 0.000217929679353838 yes 8 0.000348674264944417 51 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_374 0880-0231 82.3 µM 3.36153589244693 0.000244181840017738 yes 9 0.000387551410778942 51 6833587
SGTC_2930 9013230 14.89 µM 3.27769443772252 0.000337295623013656 yes 10 0.000523293111235634 69 2995857
SGTC_334 1502-1024 68.5 µM 3.26781982216942 0.000350210530140851 yes 11 0.000541896689873452 27 3296216
SGTC_1230 0170-0365 3.77 µM 3.08833192610988 0.000681432927059406 yes 12 0.00100641757250371 129 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2969 9091408 28.7 µM 2.98749575281644 0.000976332509405853 yes 13 0.00140636601474151 80 4286311
SGTC_2343 7990716 14.84 µM 2.98519656140636 0.000984252555339088 yes 14 0.00141698076221315 53 6456862
SGTC_620 0109-0052 432 µM 2.95804579721611 0.00108234495119755 no 15 0.00154798061732392 59 493037
SGTC_1229 0139-0193 12.2 µM 2.91712600176989 0.00124720298520156 no 16 0.00176636514849754 55 3090752
SGTC_2956 9076196 2.52 µM 2.86629318425629 0.00148389090047768 no 17 0.00207654711640122 79 16423868
SGTC_2788 5282734 71.43 µM 2.85639246257503 0.0015345060194567 no 18 0.00214242563217526 122 743706
SGTC_1466 k213-0079 57.5 µM 2.81759294910386 0.00174839605164104 no 19 0.00241925538078522 73 3657981
SGTC_521 r062-0005 13.8 µM 2.79859696248054 0.00186271208845696 no 20 0.00256625784527323 70 2832033
SGTC_2546 rhodinyl acetate 100 µM 2.77709402955963 0.00200028342498705 no 21 0.00274236546674114 65 6708682
SGTC_2416 tofa 880 nM 2.76411292272883 0.00208773581116429 no 22 0.0028538891293282 121 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2448 5185112 27.17 µM 2.71586758322073 0.00244399711987967 no 23 0.00330511753476534 71 5718189
SGTC_2279 7948423 32.93 µM 2.68037546125994 0.00274025717932165 no 24 0.00367698116222914 69 1247112
SGTC_2943 9068529 45.32 µM 2.67108904079129 0.00282294451547223 no 25 0.00378027941967167 107 3270634
SGTC_2326 6164455 177.58 µM 2.65866785041013 0.0029370618455342 no 26 0.00392251309706772 94 2888790
SGTC_3175 9106517 49.47 µM 2.65557436897253 0.00296612181935482 no 27 0.00395867369249887 72 41468073
SGTC_649 1123-0311 367 µM 2.61969861984529 0.00332256894271981 no 28 0.00440037531342646 162 693629 YIL048W NEO1
SGTC_2549 cedrol 20.94 µM 2.6132652828336 0.00339041525868262 no 29 0.00448408304161594 85 6708665 A sedative which affects the nervous system.
SGTC_2487 5918373 44.05 µM 2.59438056223258 0.0035968246487652 no 30 0.00473807659477671 97 2876279
SGTC_2059 5238311 157 µM 2.52884908161423 0.00440338331353873 no 31 0.00572186113768862 121 703021
SGTC_2987 9018338 71.43 µM 2.52815112085288 0.00441278080292799 no 32 0.00573324922778202 129 5055682
SGTC_3239 9133757 49.47 µM 2.50681649398535 0.00470881711008973 no 33 0.00609119698261142 40 17036923
SGTC_431 k089-0097 107 µM 2.50088622492216 0.00479419162117361 no 34 0.00619414850665494 179 5499420
SGTC_1282 0886-0010 32.4 µM 2.4968059752448 0.00485373128266393 no 35 0.00626587517698992 138 2836211 YNL267W PIK1
SGTC_53 0973-0023 39.979 µM 2.47299636506117 0.0052144914832741 no 36 0.00669927528818866 108 674768
SGTC_2795 7780010 54.55 µM 2.43516569429853 0.00583689221060151 no 37 0.0074424859434575 132 953673
SGTC_983 1491-0821 12.2 µM 2.43295918706158 0.00587514882387471 no 38 0.00748799441934223 90 46495113
SGTC_2333 9017922 200 µM 2.42707862171111 0.00597819494287043 no 39 0.00761047846484812 142 3163164
SGTC_1993 st073995 70.8 µM 2.41606511946091 0.00617550486005037 no 40 0.00784462758162859 117 3098394
SGTC_1058 3448-5425 97.3 µM 2.41226280816611 0.00624495179355893 no 41 0.00792692460586286 142 7279705
SGTC_2597 laccaic acid a 100 µM 2.41137864697405 0.00626119923225206 no 42 0.00794616980054553 161 5491415 A textile dye.
SGTC_2974 9094440 9.66 µM 2.40207137410625 0.00643451473542849 no 43 0.00815126361955451 166 25236134
SGTC_1469 k284-2957 126 µM 2.39824289413221 0.00650703019413276 no 44 0.00823696855123602 104 23884841
SGTC_1347 1493-0251 600 nM 2.38257579277322 0.00681136835010805 no 45 0.00859599627182661 143 3986378
SGTC_1211 1056-0033 32.3 µM 2.37460229472597 0.00697103143240444 no 46 0.00878393377221622 94 6741922
SGTC_757 1066-0008 322 µM 2.37131751258757 0.00703776171179781 no 47 0.00886239854778095 141 6842497
SGTC_2344 7990960 76.95 µM 2.3643778864947 0.00718059642458307 no 48 0.00903019011224423 128 140813
SGTC_1842 st055362 61.2 µM 2.36245783898265 0.00722056467461081 no 49 0.00907710313862235 139 676032
SGTC_3171 9103192 49.47 µM 2.3622860950463 0.00722414928606743 no 50 0.00908130978372607 73 13018434
SGTC_1957 st077035 62.4 µM 2.34391915613043 0.00761667616557655 no 51 0.00954115354589434 113 705593
SGTC_2723 salbutamol 83.58 µM 2.34060742810746 0.00768941691171001 no 52 0.00962619937231433 55 9884233 β2-adrenoceptor agonist
SGTC_1853 st056710 91.2 µM 2.33264338817551 0.00786685248393367 no 53 0.00983343486306832 146 269167
SGTC_99 0109-0120 622.8 µM 2.33095099715196 0.00790501896003683 no 54 0.00987797187344411 125 759414
SGTC_1381 2324-0066 62.1 µM 2.31091431928602 0.00836941134255071 no 55 0.010418793984074 177 10885928
SGTC_3143 9086658 49.47 µM 2.30885848816802 0.00841838823090788 no 56 0.0104757175895103 203 25236626
SGTC_1134 3477-0009 42.5 µM 2.30465136804537 0.00851940095634585 no 57 0.0105930532993033 192 3973534
SGTC_2621 lithochol-11-enic acid 100 µM 2.29094979023636 0.00885578427885745 no 58 0.0109831588976284 191 6708711
SGTC_3141 9094609 49.47 µM 2.28693986529783 0.00895640745756527 no 59 0.011099666659499 176 25236309 YDL196W YDL196W
SGTC_2656 pseudo-anisatin 100 µM 2.25343801225783 0.00983696151823585 no 60 0.0121157725259855 70 6708809 A neurotoxin.
SGTC_1684 st024538 14.6195 µM 2.25127591461436 0.00989630185851189 no 61 0.012184033654467 165 6732859
SGTC_781 4335-2806 94.4 µM 2.24787848413958 0.00999017829525331 no 62 0.0122919697467534 157 845254
SGTC_984 1492-0255 2.91 µM 2.2475052399561 0.0100005388666319 no 63 0.0123038780390586 148 1585198
SGTC_1470 k295-0292 231 µM 2.24720430529857 0.0100088990866265 no 64 0.0123134865849702 152 5045612
SGTC_1711 st032263 62.8 µM 2.23249300851043 0.0104250996373419 no 65 0.0127911983997688 129 3958979
SGTC_481 bay k-8644 50 µM 2.21745765824771 0.0108659757072414 no 66 0.0132959166995724 160 2303 A calcium channel antagonist.
SGTC_555 4296-0685 37 µM 2.21607486939474 0.0109073259634909 no 67 0.0133431875148182 146 2908540 YHR072W ERG7
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.1942030224952 0.0115798169354355 no 68 0.0141104086938625 158 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3220 9131269 49.47 µM 2.18320998310144 0.0119312114702693 no 69 0.0145101749609099 109 17722206
SGTC_1377 2944-0135 198 µM 2.17490068344405 0.0122029225245783 no 70 0.0148187798505716 210 1894137
SGTC_1330 1469-0054 61.8 µM 2.17306404594761 0.0122636984262757 no 71 0.0148877486390047 155 7102664
SGTC_253 dyclonine 31.25 µM 2.17185619363251 0.0123038100965693 no 72 0.014933255782893 192 3180 An oral anasthetic.
SGTC_1208 2323-2347 50.3 µM 2.17035368576449 0.012353865607311 no 73 0.0149900312542156 144 5412760
SGTC_1859 st055998 20 µM 2.16499568757018 0.0125338042209662 no 74 0.0151940077622851 176 676301
SGTC_1261 0712-0010 12.7 µM 2.15850874564958 0.0127546891308519 no 75 0.0154441495940608 202 2840123
SGTC_1141 3253-0389 52.6 µM 2.14229262244518 0.0133216462404112 no 76 0.0160849710706853 132 5402031
SGTC_3188 9110789 49.47 µM 2.14163831396466 0.0133449723244724 no 77 0.0161112990551169 198 849217
SGTC_1852 st056254 31.4 µM 2.12017248720386 0.0141300365505386 no 78 0.0169957508634093 163 442583
SGTC_471 1-acyl-paf 4 µM 2.11548566680933 0.0143066437431137 no 79 0.0171942876357828 185 16759367
SGTC_1224 0823-0416 294 µM 2.11148773045915 0.0144587918779304 no 80 0.0173652057123823 181 3598164
SGTC_2079 5212404 121 µM 2.10581265975079 0.0146771570270272 no 81 0.0176103143597449 158 758462
SGTC_1710 st031758 61.5 µM 2.10408278015027 0.0147442809936894 no 82 0.0176856133355136 158 5394341
SGTC_2687 chenodiol 100 µM 2.10118698908104 0.0148572364679011 no 83 0.0178122775417502 176 5702181 A cholesterol synthesis inhibitor.
SGTC_323 4013-0906 34.3 µM 2.07538903426527 0.0158967895320799 no 84 0.0189752468357822 153 2910086
SGTC_2824 7998404 51.95 µM 2.05998232212489 0.016546890506747 no 85 0.019700115419678 192 837851
SGTC_1029 k015-0030 64.7 µM 2.053547287553 0.0168250859173495 no 86 0.020009764235024 215 2208316
SGTC_1287 0971-0001 34.6 µM 2.04676020150751 0.0171228258792756 no 87 0.0203408175388705 244 4665869
SGTC_2569 tetrandrine 100 µM 2.04410682487638 0.0172404440334538 no 88 0.0204714975380714 189 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_898 1000-0849 28.3 µM 2.02949125080844 0.0179007638036461 no 89 0.0212041396168026 156 6751807
SGTC_2947 9072639 7.68 µM 2.02873795937189 0.0179353735872069 no 90 0.0212424936882255 280 16488146
SGTC_759 3486-0358 89.3 µM 2.02757477864277 0.0179889277116845 no 91 0.0213018326461292 222 875103
SGTC_3172 9105863 49.47 µM 2.01154919961444 0.0187407533219501 no 92 0.0221337395247956 92 2348785
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.01146249012363 0.018744892864851 no 93 0.0221383142513658 241 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_326 k292-0812 17.5 µM 2.01086576764427 0.0187734017238731 no 94 0.0221698185210424 145 3579357
SGTC_170 4197-0004 226 µM 2.00661612510461 0.0189775004974417 no 95 0.022395276502332 173 218692
SGTC_840 0245-0196 390 µM 2.0030361032006 0.0191509008712789 no 96 0.0225867067313698 228 3827528
SGTC_1056 3448-1962 115 µM 1.99670272614979 0.0194609612438018 no 97 0.0229287429090653 199 715507
SGTC_1426 4048-4480 71.7 µM 1.99131122203081 0.0197282611206347 no 98 0.0232233412425899 196 14224343
SGTC_1504 k297-0033 30 µM 1.98941098717493 0.0198232107927619 no 99 0.023327928948969 187 4388117
SGTC_2719 novobiocin 32.65 µM 1.9858638470712 0.0200014898260235 no 100 0.0235242220029538 117 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2673 kobusone 100 µM 1.9653066446207 0.021061689112761 no 101 0.0246893785028397 138 6710676 An epoxy ketone and protein crosslinker.
SGTC_842 0271-0008 11.1 µM 1.95991590294231 0.0213474492944114 no 102 0.0250028102647504 228 1221709
SGTC_1905 st060207 84.5 µM 1.95827913542773 0.0214348595723291 no 103 0.0250986338442114 192 1948547
SGTC_2275 7947463 200 µM 1.95640050153286 0.0215355592881792 no 104 0.0252089965691758 204 1225414
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.95480915206583 0.0216211723231474 no 105 0.0253028002692989 260 165506
SGTC_812 4251-0442 148 µM 1.95286285808286 0.0217262718241398 no 106 0.0254179239075253 191 5723007
SGTC_2159 5658611 73.75 µM 1.94991260109511 0.021886407898332 no 107 0.0255932684775424 171 793844
SGTC_1943 st076331 65.2 µM 1.94681605776517 0.0220555551375898 no 108 0.0257783955592308 218 24208415
SGTC_3223 9129970 49.47 µM 1.94506172161626 0.0221518736763461 no 109 0.0258837751039667 241 17248386
SGTC_2815 7968870 71.43 µM 1.94351204195135 0.0222372509831285 no 110 0.0259771609251644 279 2977326 YHR190W ERG9
SGTC_2287 7945887 168.79 µM 1.93558981968266 0.0226780637424138 no 111 0.026458979102538 218 1245853
SGTC_3182 9108849 49.47 µM 1.93396150265601 0.0227695741692326 no 112 0.0265589306558542 264 17133045
SGTC_2887 9044784 58.44 µM 1.93316578447593 0.0228144061137966 no 113 0.0266078891281799 271 6465546
SGTC_2683 piperine 63.03 µM 1.92766909746579 0.0231261334705562 no 114 0.0269481491103733 195 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1349 flufenamic acid 69 µM 1.92209196282004 0.0234460808839281 no 115 0.0272970936035475 219 3371 A non-steroidal anti-inflammatory.
SGTC_3161 9100388 49.47 µM 1.91600741098169 0.023799377423741 no 116 0.0276820761915158 187 25236368
SGTC_1057 3448-5381 134 µM 1.90736272939897 0.0243090146471381 no 117 0.0282368161127267 260 5497911
SGTC_1112 tnp00069 1.16933 µM 1.89845732970211 0.024843573388631 no 118 0.0288179318361966 268 145826
SGTC_1920 st075728 45.7 µM 1.89514316056716 0.0250450121059826 no 119 0.0290367189784374 258 3400306
SGTC_768 0384-0033 77.3 µM 1.89067252469204 0.0253189097517651 no 120 0.0293340361536613 334 3965305 YMR134W ERG29
SGTC_1131 3454-3128 32.3 µM 1.89002732524382 0.0253586449467164 no 121 0.0293771528187367 303 710982
SGTC_2023 5144124 124 µM 1.88974361331954 0.0253761341323656 no 122 0.0293961290517889 244 2830192
SGTC_2492 derrusnin 100 µM 1.88505803507832 0.0256664371244014 no 123 0.0297110014545377 176 1715307 Part of coumarin class of compounds.
SGTC_2724 maprotiline 69.64 µM 1.87294962565566 0.0264295330864032 no 124 0.0305376707352687 223 4011 A tricyclic antidepressant.
SGTC_1498 4478-3555 97.6 µM 1.85069784469617 0.027881329145598 no 125 0.0321065171579627 184 3437919
SGTC_1896 st058441 89 µM 1.84861158812761 0.0280207875479074 no 126 0.0322569591002745 236 688759
SGTC_83 0170-0301 39.027 µM 1.84288695228954 0.0284064445946094 no 127 0.032672758855315 128 3089716
SGTC_1329 1447-1697 50.6 µM 1.8420703636119 0.0284618147731935 no 128 0.0327324290858106 277 2840515
SGTC_257 daunorubicin 18.5 µM 1.83485615913366 0.0289548976765126 no 129 0.0332635024912875 218 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2442 5158906 48.48 µM 1.833412356846 0.0290544277617893 no 130 0.0333706356810091 275 1893835
SGTC_1233 0325-0408 14.2 µM 1.83222789560991 0.0291362920116114 no 131 0.0334587372281741 272 12874
SGTC_2291 7917025 104.35 µM 1.83009863727682 0.0292839379427655 no 132 0.0336175953446724 323 2964612
SGTC_423 5-fluorouracil 457 µM 1.82787978509038 0.0294384570545201 no 133 0.0337837977722365 283 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_397 arbidol 50 µM 1.8266131032912 0.0295269708873823 no 134 0.0338789809139188 289 131410 A RNA synthesis inhibitor.
SGTC_319 1348-1596 45.5 µM 1.82239965267791 0.0298229915454788 no 135 0.034197183626897 273 5380505
SGTC_1214 0358-0031 63.7 µM 1.82107543398045 0.0299165329050454 no 136 0.0342976954838357 284 4301366
SGTC_740 k014-0057 261 µM 1.81923173384962 0.0300471750065235 no 137 0.0344380416564174 318 4012779
SGTC_771 0250-0039 27.3 µM 1.81656976451688 0.0302366327999664 no 138 0.0346415082961342 263 3005115
SGTC_3286 9117135 37.221 µM 1.81288248397381 0.0305006987233557 no 139 0.0349249741860118 280 3438150
SGTC_841 0251-0215 91.2 µM 1.8069198086818 0.0309317585057755 no 140 0.0353873917458957 355 3888614
SGTC_2762 leflunomide 42.06 µM 1.80466724472827 0.0310959098609964 no 141 0.0355633842133504 313 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2718 lomofungin 53.02 µM 1.80074444255507 0.0313834968762338 no 142 0.0358715846215818 246 5351222 A RNA synthesis inhibitor.
SGTC_3037 9091026 49.47 µM 1.79395236089711 0.0318866342199805 no 143 0.0364103864651371 444 25236398 YIL048W NEO1
SGTC_909 3448-9333 149 µM 1.78567028917853 0.0325091418337159 no 144 0.0370763293432337 272 3344074
SGTC_536 3852-0578 10.6 µM 1.78352077641198 0.0326723347188888 no 145 0.0372507845047905 273 2869208
SGTC_2036 5160441 105 µM 1.77845107184711 0.0330599078621877 no 146 0.0376649005286384 373 134534 YIL048W NEO1
SGTC_1747 st037496 66.6 µM 1.77309860550102 0.0334732008532319 no 147 0.0381061845164049 315 723305
SGTC_2272 7805186 180 µM 1.77280807031382 0.0334957558204704 no 148 0.0381302578418721 255 2956062 YPR165W RHO1
SGTC_395 anisomycin 6.25 µM 1.76865307624233 0.0338196894288671 no 149 0.0384758937394349 231 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1184 1269-1718 139 µM 1.76787224690603 0.033880851565878 no 150 0.0385411317124206 291 5403821
SGTC_602 3130-1533 38.1 µM 1.76626507480283 0.0340070272791891 no 151 0.0386756940173028 339 720941
SGTC_2490 carminic acid 95.39 µM 1.76613500604877 0.0340172555844518 no 152 0.0386866008927449 206 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2113 5491891 107.031 µM 1.76536677760757 0.0340777188977995 no 153 0.0387510715730333 315 789979
SGTC_3304 9125678 46.087 µM 1.76524361656277 0.0340874204849076 no 154 0.0387614155359351 333 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3115 9123671 49.47 µM 1.75356409791472 0.0350178057723254 no 155 0.0397526136766649 238 3286988
SGTC_1451 4152-0210 104 µM 1.74455466587342 0.0357496459541423 no 156 0.0405312089641374 326 659563
SGTC_3109 9122853 49.47 µM 1.74416700565795 0.0357814149203883 no 157 0.0405649864114172 277 1234709
SGTC_1323 1348-1351 11.2 µM 1.74203399624861 0.0359566302810894 no 158 0.0407512478563699 259 6989654
SGTC_1457 k015-0032 57.3 µM 1.7409563238942 0.0360454222133475 no 159 0.0408456173288177 335 4302660
SGTC_2759 disulfiram 3.38 µM 1.73472346615746 0.0365624908678364 no 160 0.0413948989046722 316 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2081 5214970 32.255 µM 1.71483182404631 0.0382533912695573 no 161 0.0431880325174436 304 2063512
SGTC_2354 9060492 162 µM 1.71280542471609 0.0384291685327856 no 162 0.0433741709071537 346 6471895
SGTC_626 0214-0009 33 µM 1.7116356166384 0.0385309413321616 no 163 0.0434819201820434 319 3437874
SGTC_1089 terbinafine 2.25 µM 1.71116751400885 0.0385717275452512 no 164 0.0435250968990286 299 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3185 9108267 49.47 µM 1.70898459604577 0.0387623920187815 no 165 0.0437269014314891 344 4910486
SGTC_2337 9009472 200 µM 1.70740795401403 0.0389005789624063 no 166 0.0438731264965756 366 5742383
SGTC_2799 7812892 81.82 µM 1.69949565497271 0.0396001337604081 no 167 0.0446129162811273 339 20205235
SGTC_2372 9071633 200 µM 1.69930668980977 0.0396169651238689 no 168 0.0446307063784488 334 21321366
SGTC_719 2810-4230 27.3 µM 1.69847424141587 0.0396911816232523 no 169 0.0447091451503605 250 721079
SGTC_1819 st053448 58.6 µM 1.69699314458418 0.0398235075159415 no 170 0.0448489783089298 306 2857616
SGTC_43 0570-0105 72.5 µM 1.68681794181858 0.0407423159144414 no 171 0.0458191822093514 486 1114046 YDL195W SEC31
SGTC_776 4476-4378 112 µM 1.68567166524458 0.0408468927891831 no 172 0.0459295286641963 291 2892008
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.68372987558336 0.0410245425931108 no 173 0.0461169424152629 325 7104
SGTC_51 1013-0126 23.419 µM 1.68131903894398 0.0412459757989377 no 174 0.0463504808707283 315 1627850
SGTC_260 nsc-65238 3.989 µM 1.6770799583698 0.0416376806040133 no 175 0.046763423648249 297 3246252
SGTC_162 k030-0015 37.8 µM 1.67220256321848 0.0420920901622538 no 176 0.0472421926140882 318 1809920 YMR134W ERG29
SGTC_1913 st060213 96.1 µM 1.67202275767786 0.0421089184128969 no 177 0.0472599172765931 383 688959
SGTC_868 0527-0199 213 µM 1.66806802640467 0.042480426103307 no 178 0.0476511117296316 345 2849450
SGTC_3163 9099914 49.47 µM 1.6673143663553 0.0425515248048975 no 179 0.0477259557297669 222 16268368
SGTC_2223 6903751 107.57 µM 1.66719263676428 0.0425630175392123 no 180 0.0477380532012974 257 5598863
SGTC_2123 5259487 200 µM 1.6523012897736 0.0439879839783619 no 181 0.0492365732610826 344 2173474
SGTC_2836 9010338 19.48 µM 1.64533753020352 0.0446674293539981 no 182 0.0499501121869041 340 2994051
SGTC_2133 5320837 200 µM 1.64529153742705 0.044671944750223 no 183 0.04995485208606 348 2841355
SGTC_1833 st055984 71 µM 1.64504124930647 0.0446965235320733 no 184 0.0499806524339744 324 676288
SGTC_1321 1326-2144 215 µM 1.63705891242859 0.0454861335350001 no 185 0.0508090802998155 318 3513030
SGTC_2389 9091542 195.52 µM 1.63354935157336 0.0458368299546547 no 186 0.0511767550513866 391 3626624 YOL127W RPL25
SGTC_376 3970-0862 59.1 µM 1.63269566204842 0.0459224634735581 no 187 0.0512665101226449 358 3135186
SGTC_1503 4585-0012 61.3 µM 1.62883140451262 0.0463116958884858 no 188 0.0516743572807246 326 2922052
SGTC_452 diindolylmethane 8 µM 1.60992266248924 0.0482546490540563 no 189 0.0537073704315707 305 3071 Inhibits expression of several cancer promoting factors.
SGTC_1922 5578187 25 µM 1.60938738293804 0.0483105862087973 no 190 0.053765831204187 366 1350412
SGTC_2950 9072895 21.46 µM 1.60155265052821 0.0491352723886509 no 191 0.0546272842186225 422 17332245
SGTC_2769 toremifene 3.73 µM 1.60155059728531 0.0491354899780878 no 192 0.0546275114010622 351 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1826 st055655 41.6 µM 1.59814448145038 0.0494975090519878 no 193 0.0550054130658753 387 676168
SGTC_3146 9095609 49.47 µM 1.59521825549066 0.0498102203352724 no 194 0.0553317189142565 346 17173999
SGTC_724 3910-0327 137 µM 1.59361030052064 0.049982724269497 no 195 0.0555116729810062 379 2885483
SGTC_479 n-linoleoylglycine 10 µM 1.59331447848825 0.0500145123468707 no 196 0.0555448301287177 305 6433346 An anti-infammatory.
SGTC_416 estradiol valerate 100 µM 1.58809648740488 0.0505778751433066 no 197 0.0561322612466468 362 13791 A steroid.
SGTC_713 1488-1073 324 µM 1.58424239320277 0.050997220832201 no 198 0.0565692847380475 336 3312542
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.58286868628143 0.0511473546229621 no 199 0.0567256986317217 428 5024745
SGTC_2649 anisomycin 9.56 µM 1.581222023136 0.0513277833145808 no 200 0.0569136407563129 327 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2635 hydroquinidine 100 µM 1.57909748500254 0.0515613214956761 no 201 0.0571568492399609 377 442912 An experimental heart treatment.
SGTC_1412 3909-8563 178 µM 1.57882949648828 0.0515908398363679 no 202 0.0571875854900002 412 23767530
SGTC_3192 9110362 49.47 µM 1.57069864663743 0.0524928399809786 no 203 0.0581263318565136 378 16649480
SGTC_2984 9022109 38.96 µM 1.56719091247422 0.0528858174305896 no 204 0.0585350369797467 296 6459207
SGTC_1310 1188-0297 994 nM 1.56419444724223 0.0532233615561105 no 205 0.0588859554236314 398 1588352
SGTC_593 1203-0218 61.7 µM 1.56379854338337 0.0532680865568129 no 206 0.0589324432443699 374 3666956
SGTC_878 0828-0289 13.7 µM 1.56172935483634 0.0535023263756802 no 207 0.0591758801871041 466 745350 YLR208W SEC13
SGTC_560 2332-1943 155 µM 1.56079591003257 0.0536082625698362 no 208 0.0592859563865531 373 21177716
SGTC_2690 usnic acid 100 µM 1.55988671718035 0.053711606099053 no 209 0.0593933269691038 457 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3184 9108758 49.47 µM 1.55102337978476 0.0547273445571009 no 210 0.060448040593466 342 902885
SGTC_1857 st056007 79.3 µM 1.55038171047514 0.0548014653876811 no 211 0.0605249628592068 343 619834
SGTC_963 1269-2853 151 µM 1.54830434577716 0.0550419713927963 no 212 0.0607745193252753 390 3668223
SGTC_1928 4'-methoxychalcone 40.3 µM 1.54767130667113 0.0551154267805119 no 213 0.0608507268748946 371 641818
SGTC_307 1501-1223 22.3 µM 1.54589483752074 0.0553219749734666 no 214 0.0610649837752027 378 2830329
SGTC_2098 5376439 882.5 nM 1.54174434871978 0.0558069304144392 no 215 0.0615678651874422 422 2844116
SGTC_3035 9091303 49.47 µM 1.54144412996703 0.0558421385456166 no 216 0.0616043653406238 348 25237002
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.5391944617827 0.056106526190238 no 217 0.0618784146359927 444 5379071
SGTC_1605 st000082 49.1 µM 1.53661107789169 0.0564113496496672 no 218 0.062194289073788 370 1114022
SGTC_930 2810-3379 265 µM 1.5355139620375 0.0565411968135542 no 219 0.0623288150843038 465 1015764
SGTC_752 1896-0090 130 µM 1.52921603636645 0.0572911383877589 no 220 0.0631054481928055 407 772567
SGTC_888 0916-0002 6.97 µM 1.52741939992216 0.0575065062944244 no 221 0.0633283777147425 387 2802138 YIL048W NEO1
SGTC_3130 9127414 49.47 µM 1.52442015298362 0.0578674529006212 no 222 0.0637018944829164 367 1494646
SGTC_2720 fluspirilene 36.88 µM 1.52364153318546 0.0579614470631455 no 223 0.0637991410184584 334 3396 An atypical antipsychotic.
SGTC_1235 benzylparaben 21.5 µM 1.51988844214202 0.0584162005396942 no 224 0.0642695078852543 395 7180
SGTC_1369 1866-0067 208 µM 1.51966077655288 0.0584438761461849 no 225 0.0642981272012977 470 3531355
SGTC_850 0388-0143 75.9 µM 1.51697536189312 0.0587710995197381 no 226 0.0646364523495045 394 67273
SGTC_2484 5809818 12.04 µM 1.51266144584075 0.0592997673814652 no 227 0.0651828387615288 403 2870548
SGTC_978 1416-0512 87.4 µM 1.51176153603573 0.0594105194306283 no 228 0.0652972688728565 472 6814003
SGTC_2942 9052777 62.25 µM 1.50175660813427 0.0606527776754628 no 229 0.0665799891970939 468 6469503
SGTC_1795 st049545 62.3 µM 1.50153857491457 0.0606800741897408 no 230 0.0666081585936417 401 5291882
SGTC_1175 0741-0056 27.6 µM 1.4986796634439 0.0610388832392302 no 231 0.066978377487076 489 765927
SGTC_310 1273-0058 1.06 µM 1.49462319787811 0.0615508352614026 no 232 0.0675064042066282 684 2734232
SGTC_1317 1273-0028 910 nM 1.49422635019002 0.0616010995321943 no 233 0.0675582338018343 415 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1427 4048-4900 550 nM 1.49245606362708 0.0618257124942684 no 234 0.0677898135641267 419 24132586
SGTC_1831 st055328 12 µM 1.48919512674042 0.0622411311291427 no 235 0.0682179968545096 427 1103068
SGTC_2049 5262831 67.185 µM 1.48815224605899 0.0623744447107433 no 236 0.0683553738445316 415 763417
SGTC_1174 0739-0097 51.1 µM 1.48588487757664 0.0626650553327974 no 237 0.0686547871177678 443 728447
SGTC_2334 9017922 200 µM 1.47131275995093 0.0645580309688455 no 238 0.0706032770523426 419 3163164
SGTC_330 1488-0319 80.1 µM 1.46979873001488 0.0647572299017954 no 239 0.0708081366151499 423 6846614
SGTC_3110 9122132 49.47 µM 1.46483686285653 0.065413402602595 no 240 0.0714827159465379 440 918317
SGTC_723 4182-0001 115 µM 1.46082284622699 0.0659479924411789 no 241 0.0720320321908202 422 744821 YLR208W SEC13
SGTC_155 k072-0202 43.6 µM 1.45870656061896 0.0662312007063155 no 242 0.0723229448094531 399 5857737
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.45657025580407 0.0665180424659834 no 243 0.0726175215975343 371 61125 An anti-inflammatory.
SGTC_490 phenamil 164 µM 1.45411487636092 0.0668489131966353 no 244 0.0729572299093366 320 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2222 6885208 172.143 µM 1.45281263294833 0.0670249109090839 no 245 0.0731378917247572 369 609514
SGTC_3267 9137951 49.47 µM 1.44443519240714 0.0681656995730374 no 246 0.0743082986667993 375 16643986
SGTC_515 4092-1064 102 µM 1.44170186092094 0.0685411329509641 no 247 0.0746932492174751 516 717353
SGTC_703 3875-0075 71.8 µM 1.43804461667789 0.0690459615726536 no 248 0.0752106976106072 448 2850814
SGTC_101 0490-5701 117.494 µM 1.43799584742039 0.0690527127581304 no 249 0.0752176161904134 394 4661669
SGTC_1126 isoteolin 1.0172 µM 1.43574577195628 0.0693647468661651 no 250 0.0755373477807895 460 133323
SGTC_1640 st009078 66.4 µM 1.43481597891694 0.069494004616078 no 251 0.0756697716531807 387 690618
SGTC_2816 7982706 58.44 µM 1.43421708704227 0.0695773593887898 no 252 0.0757551612019024 463 2981853
SGTC_1241 0364-0022 50.8 µM 1.43046677433548 0.0701010856333326 no 253 0.0762915476485459 483 4563895
SGTC_1046 2001-0062 216 µM 1.42855867395076 0.0703687107170263 no 254 0.0765655596137368 468 739778
SGTC_3092 9117248 49.47 µM 1.42697580247122 0.0705913156351635 no 255 0.076793434743086 450 17141857
SGTC_2054 5233173 129 µM 1.42691684396984 0.070599617625057 no 256 0.0768019325438155 522 6889
SGTC_554 4483-2211 187 µM 1.4246649727184 0.0709172672829329 no 257 0.0771270344350655 465 747107
SGTC_2419 paclitaxel 166.5 µM 1.42452483801587 0.0709370709547612 no 258 0.0771473001444802 543 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1619 st003326 88.7 µM 1.42423220222384 0.0709784395989027 no 259 0.0771896329864791 421 2849032
SGTC_1712 st032288 53.4 µM 1.42369737023311 0.0710540943393922 no 260 0.077267047655462 653 2883011
SGTC_2961 9083290 32.55 µM 1.41051691512417 0.0729381689856677 no 261 0.0791935526860542 427 17741490
SGTC_3229 9132204 49.47 µM 1.40728563626382 0.0734058481090019 no 262 0.0796713534161117 401 17682924
SGTC_2060 5238662 140 µM 1.39686713543746 0.0749293949379225 no 263 0.0812267645264699 467 790130
SGTC_1007 4101-0031 70 µM 1.39667824305445 0.0749572385169798 no 264 0.0812551748318913 506 1146276
SGTC_1040 k898-0338 155 µM 1.39499881120204 0.0752051413696144 no 265 0.0815080990254068 524 20969351
SGTC_34 0469-0683 81.75 µM 1.39343556396339 0.0754364553502529 no 266 0.0817440587848969 455 3690923
SGTC_615 k087-0205 167 µM 1.39006687008078 0.0759367643230842 no 267 0.0822542862116269 473 9642773
SGTC_1555 citronellol 128 µM 1.38896448441474 0.0761010350692908 no 268 0.0824217750149069 444 8842 A terpine precursor.
SGTC_3198 9112019 49.47 µM 1.38574496190546 0.0765823372657021 no 269 0.0829123968514699 472 45595555
SGTC_1061 3448-9325 110 µM 1.37894834211233 0.0776059956159666 no 270 0.0839553408544894 453 723482
SGTC_966 1300-0360 30.2 µM 1.37704122854967 0.0778950897175477 no 271 0.0842497507336041 488 70588
SGTC_3156 9099931 49.47 µM 1.37467492448919 0.0782549264424005 no 272 0.0846161243052872 496 18111053
SGTC_1358 1509-0022 2.48 µM 1.37326666779338 0.0784696733578032 no 273 0.0848347304092436 501 3258434
SGTC_2253 7938677 135.83 µM 1.37290299239247 0.0785252032152196 no 274 0.0848912531026324 467 2301972
SGTC_2261 9010538 184.68 µM 1.36851245023388 0.0791979507738608 no 275 0.0855758637926988 414 6457250
SGTC_643 k048-0106 28.4 µM 1.36609067616476 0.0795708934617388 no 276 0.0859552522122243 504 6763920
SGTC_2227 7312221 64.1025 µM 1.36569182860004 0.0796324414917635 no 277 0.0860178550942904 448 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_788 1182-0090 188 µM 1.36322823505546 0.0800134087059547 no 278 0.086405295656423 625 5715185
SGTC_2677 mitomycin C 100 µM 1.36066828369985 0.0804107348184391 no 279 0.0868092709433835 431 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2975 9084847 53.72 µM 1.35864924340267 0.0807251570706899 no 280 0.087128881489558 508 27211724
SGTC_782 0083-0095 30.5 µM 1.34988758022003 0.0821003613430827 no 281 0.0885260230640011 562 3591729 An indicator and reagent.
SGTC_3147 9097027 49.47 µM 1.34973578053694 0.0821243419391135 no 282 0.0885503753921926 541 25236841
SGTC_906 1165-0455 526 µM 1.34769104925812 0.0824478733269741 no 283 0.0888788860652092 494 3252859
SGTC_685 1278-0033 54.9 µM 1.34274428664139 0.0832345517716069 no 284 0.0896773945791143 543 3590572
SGTC_1295 1013-0063 9.78 µM 1.34147350190881 0.083437551518024 no 285 0.0898833836816261 525 6826038
SGTC_2872 9044037 25.97 µM 1.33957091698818 0.0837421725903244 no 286 0.0901924421308488 441 6465195
SGTC_1262 0737-0114 49.6 µM 1.33927797564771 0.0837891492752143 no 287 0.0902400979588773 598 765919
SGTC_2294 7971431 200 µM 1.33880169252269 0.08386556928093 no 288 0.0903176198306938 444 5741572
SGTC_2317 5986382 200 µM 1.33863869783982 0.0838917339259928 no 289 0.0903441608959808 520 877883
SGTC_2132 5317594 122.667 µM 1.33440427303324 0.0845736131296359 no 290 0.0910357002029825 454 794577
SGTC_1622 st003707 19.4 µM 1.33326309101339 0.0847580895590814 no 291 0.0912227407134958 566 10140899
SGTC_1791 st048313 56.1 µM 1.33285039760741 0.0848248772618728 no 292 0.0912904515537763 464 1204976
SGTC_701 4424-0219 185 µM 1.33281536177972 0.0848305490563014 no 293 0.0912962016173477 583 2911779
SGTC_1985 st071382 65.5 µM 1.33200445010878 0.0849619034082339 no 294 0.0914293630995623 512 6123237
SGTC_1725 st036284 20.55 µM 1.32865366627928 0.0855062921829683 no 295 0.0919811289110926 581 707914
SGTC_1735 st034310 56.75 µM 1.32591835168325 0.0859526212964456 no 296 0.0924333717834037 534 871153
SGTC_2917 7979103 53.79 µM 1.32454878867605 0.086176750747985 no 297 0.0926604254742851 595 2980565
SGTC_741 4582-0002 126 µM 1.32410846288024 0.0862489030065819 no 298 0.0927335126719089 527 2912688
SGTC_3221 9128209 49.47 µM 1.31954196677884 0.0869998398360234 no 299 0.0934939948212412 487 16460723
SGTC_2674 ligustilide 100 µM 1.31593688466604 0.0875961184146295 no 300 0.0940976137556147 477 5319022 A signalling regulator.
SGTC_1348 1493-0373 93.8 µM 1.31421155165928 0.0878825641721499 no 301 0.0943875110827294 516 3010129
SGTC_1673 st016611 27.3 µM 1.31299905152874 0.0880842852339458 no 302 0.09459163388763 552 5226799
SGTC_1218 1348-1416 30.7 µM 1.31267072481778 0.0881389675971057 no 303 0.0946469632056347 546 6787668
SGTC_2794 7785382 27.27 µM 1.31167483960336 0.088304985705128 no 304 0.0948149347851951 638 2205081
SGTC_804 1595-0054 20.9 µM 1.30813054341958 0.0888977250164703 no 305 0.0954145176525728 516 761523 Stimulates phospholipase C.
SGTC_278 4092-0821 23.9 µM 1.30804637045969 0.0889118378149555 no 306 0.0954287909073341 535 877900
SGTC_2622 2-methoxyxanthone 59.94 µM 1.30720621166533 0.0890527938545502 no 307 0.0955713432350022 560 71034 A hepatoprotective.
SGTC_3085 9117376 49.47 µM 1.30702880652045 0.0890825789209691 no 308 0.0956014641399577 541 16480349
SGTC_415 dibenzyl ketone 100 µM 1.30253825079216 0.0898389825117986 no 309 0.0963662254498906 555 7593
SGTC_1559 coumarin 343 70.1 µM 1.30221933906692 0.0898928820265672 no 310 0.0964207080043149 488 108770 A hepatotoxic, DNA x-linker.
SGTC_215 1287-0124 461.5 µM 1.30170058381575 0.0899806085856351 no 311 0.0965093799714661 457 5560863
SGTC_1450 4112-4260 37.6 µM 1.30075227357676 0.0901411414924945 no 312 0.096671631550628 565 1633175
SGTC_2190 6049624 200 µM 1.29997841455623 0.0902723003325328 no 313 0.0968041837046182 466 2265554
SGTC_2281 7943571 200 µM 1.29940273249636 0.0903699627097952 no 314 0.0969028772168193 558 1244024
SGTC_1733 st037357 54.9 µM 1.29196263797375 0.0916392153604518 no 315 0.0981850418578631 572 1272339 YGL099W LSG1
SGTC_281 1672-3440 14.9 µM 1.29134484850394 0.091745198936922 no 316 0.0982920627979317 595 6833000
SGTC_667 1498-1044 59 µM 1.29073885398363 0.0918492472498182 no 317 0.0983971234571083 558 6739982
SGTC_2875 9039966 71.43 µM 1.28901620206599 0.0921455012304974 no 318 0.0986962269744256 502 6463691
SGTC_3088 9117578 49.47 µM 1.28846415194444 0.0922405898562564 no 319 0.098792219919057 526 678341
SGTC_3203 9113543 49.47 µM 1.28759971243475 0.092389632297286 no 320 0.0989426697515014 538 17018012
SGTC_660 4031-1742 102 µM 1.2872733807812 0.0924459431191476 no 321 0.0989995091229744 593 6738706
SGTC_1150 3909-7983 10.9 µM 1.28685948046345 0.0925174010555444 no 322 0.0990716352708306 586 23965914
SGTC_682 0kpi-0099 17 µM 1.28666407671746 0.0925511507865823 no 323 0.0991056996228015 592 1714895 YML126C ERG13
SGTC_677 0929-0063 136 µM 1.2822554135619 0.0933150286444415 no 324 0.0998765315509511 480 1539583
SGTC_1588 farnesol 29.9 µM 1.28011814388559 0.0936870199914782 no 325 0.100251794226588 554 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1810 st050138 53 µM 1.27874791679201 0.0939260830207684 no 326 0.100492920039823 501 3444541
SGTC_2458 5808907 16.39 µM 1.27730957261239 0.0941775144289722 no 327 0.100746487687188 583 2731747
SGTC_2153 5569715 200 µM 1.27240625332855 0.0950383760065129 no 328 0.101614406697019 540 2054701
SGTC_1289 0976-0073 69.1 µM 1.27003524744941 0.0954567196787757 no 329 0.102036037509269 595 3391136
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.26492538981666 0.0963629155913415 no 330 0.102949037408175 530 6708514
SGTC_1209 2323-2347 50.3 µM 1.26352830280455 0.0966117758024095 no 331 0.103199690880847 541 5412760
SGTC_1621 st003705 32.4 µM 1.26243274180667 0.0968072558241967 no 332 0.103396556908475 627 24207032
SGTC_359 0081-0058 15.9 µM 1.26211990687421 0.0968631279686088 no 333 0.103452821554941 546 3494159
SGTC_1816 st051957 91.6 µM 1.25985639602418 0.0972680953140634 no 334 0.103860585480884 562 674121
SGTC_2355 9061122 103.12 µM 1.2582255345233 0.0975606436620801 no 335 0.104155101424003 558 5302957
SGTC_418 lividomycin a 100 µM 1.25740773078606 0.0977075861926137 no 336 0.10430301564533 610 72394 An antibiotic.
SGTC_1968 st069590 43.6 µM 1.25720246717977 0.097744493307438 no 337 0.104340165076127 558 6384066
SGTC_1392 3455-1037 33.9 µM 1.25599755780369 0.0979613463284766 no 338 0.104558427767283 583 981132
SGTC_1635 st007035 42.4 µM 1.25486230148209 0.0981659859669778 no 339 0.104764375638008 766 3716403
SGTC_1997 st073024 93.8 µM 1.25387473142688 0.0983442584557728 no 340 0.104943770397664 576 686268
SGTC_2303 7774051 200 µM 1.24888523584208 0.0992485695347115 no 341 0.105853526205585 555 2953184
SGTC_3258 9138477 49.47 µM 1.24886864724531 0.0992515862087586 no 342 0.105856560352119 575 4970355
SGTC_263 alizarin 107.927 µM 1.24815408847291 0.0993815939978082 no 343 0.105987316799374 665 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2731 amoxapine 43.43 µM 1.24787909168894 0.0994316604440405 no 344 0.106037669294167 456 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2623 humulene 100 µM 1.24496610124872 0.0999631375029685 no 345 0.106572105565654 504 6187145 An anti-inflammatory.
SGTC_507 nimesulide 162 µM 1.24251462145754 0.100412016809215 no 346 0.107023374594578 600 4495 A COX2 inhibitor.
SGTC_213 1246-0773 967 nM 1.24018449466379 0.100840037480414 no 347 0.107453581035877 611 6251622
SGTC_2149 5554786 194.827 µM 1.23775349664401 0.101288003555346 no 348 0.107903738153542 625 745063 YPR165W RHO1
SGTC_1590 st077108 57.8 µM 1.23674928004318 0.101473475622582 no 349 0.10809008859688 570 5489485
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.23642559405528 0.101533310936773 no 350 0.108150203699235 573 75037 A free radical scavenger.
SGTC_1921 5740136 50 µM 1.23313527797229 0.102143004450073 no 351 0.108762648767477 655 1774243
SGTC_725 1497-0963 19 µM 1.23249595004681 0.102261779917716 no 352 0.10888193928179 613 3549977
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.22971577658171 0.10277945376262 no 353 0.109401778418777 574 6710655
SGTC_1302 1159-0335 255 µM 1.22937783715184 0.102842508336265 no 354 0.109465087923528 577 649284
SGTC_532 1548-0774 215 µM 1.22701169210505 0.103284784033561 no 355 0.109909098215724 630 5932993
SGTC_1581 himbacine 57.9 µM 1.22666435462782 0.103349823809732 no 356 0.109974385191595 623 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2514 salinomycin 42.74 µM 1.22608372844325 0.103458613841673 no 357 0.110083584199562 671 23682228 A polyether potassium ionophore.
SGTC_2160 5660466 132.927 µM 1.22598636753298 0.103476864171835 no 358 0.11010190258631 584 2859134
SGTC_678 1218-2179 85.9 µM 1.22513431200762 0.103636681933865 no 359 0.110262309549209 546 6820081 YOR116C RPO31
SGTC_2721 ifenprodil 61.44 µM 1.22053954994686 0.104501596702631 no 360 0.111130203103537 592 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1360 1598-0022 39.8 µM 1.22032665354136 0.104541798562625 no 361 0.111170534840554 699 761525
SGTC_2880 9042983 58.44 µM 1.21991652449237 0.104619276027318 no 362 0.111248260464851 622 6464714
SGTC_261 5-fluorouridine 15.376 µM 1.21796298739035 0.104988889558983 no 363 0.111619019142587 613 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2592 piperlongumine 83.33 µM 1.21631961663271 0.105300550235334 no 364 0.111931595817236 560 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1553 gossypol 38.6 µM 1.21532820475714 0.105488892133834 no 365 0.11212046935138 470 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_212 3807-4682 38.772 µM 1.2149935521027 0.105552522208831 no 366 0.112184275313127 760 3125501 YBL034C STU1
SGTC_940 3232-1287 54.8 µM 1.21445693588171 0.105654611093691 no 367 0.112286642470261 621 1585493 YIL048W NEO1
SGTC_3191 9110352 49.47 µM 1.21297649400491 0.105936628796736 no 368 0.112569403823053 580 17122424
SGTC_2695 st077686 51.995 µM 1.2102288831672 0.106461477609256 no 369 0.113095538964829 575 2876092
SGTC_2643 anethole 100 µM 1.20626746881118 0.107221488027853 no 370 0.113857188362062 646 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1989 st071868 50.2 µM 1.20397653349449 0.10766279291862 no 371 0.11429932434801 620 16414057
SGTC_3165 9101544 49.47 µM 1.20218890125501 0.108008053947467 no 372 0.114645174213426 616 5002184
SGTC_156 3474-0145 5.642 µM 1.20212907769888 0.108019621963774 no 373 0.114656761028817 624 2265471
SGTC_3138 9097216 49.47 µM 1.19946132653309 0.108536389340679 no 374 0.115174306907472 595 25237486
SGTC_2124 5246320 200 µM 1.19681851237515 0.109050077424891 no 375 0.115688650524424 614 579342
SGTC_188 3229-0966 278.469 µM 1.19403600092945 0.109592804575711 no 376 0.116231942910275 732 5722370
SGTC_1718 roemerine 11.9335 µM 1.19293920854305 0.109807265292791 no 377 0.1164465910962 673 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2698 st077697 67.5 µM 1.19210361257561 0.109970855151453 no 378 0.116610310338808 592 3154499
SGTC_2462 5162487 171.77 µM 1.18974559834218 0.110433441243321 no 379 0.117073198731754 639 2259986
SGTC_852 0418-0143 439 µM 1.18836416046169 0.110705093581294 no 380 0.117344984985261 702 5369229
SGTC_2338 7999974 200 µM 1.18629116409332 0.11111363509992 no 381 0.117753667420265 686 315925
SGTC_1815 st051655 58.2 µM 1.1856894256924 0.111232426295314 no 382 0.117872485999318 587 5984156
SGTC_3036 9090181 49.47 µM 1.18282215794094 0.111799712104851 no 383 0.118439818507921 624 25236586
SGTC_1207 2099-0101 141 µM 1.18274905282221 0.111814202875811 no 384 0.118454308655783 684 5837381
SGTC_81 0411-0046 9.971 µM 1.18050013126534 0.11226063669908 no 385 0.118900679137758 588 12925265
SGTC_440 fluspirilene 35.1 µM 1.17842912678567 0.11267287750942 no 386 0.119312785779722 641 3396 An atypical antipsychotic.
SGTC_624 k048-0052 28 µM 1.17808544331086 0.112741393380658 no 387 0.119381272335243 615 6835531
SGTC_810 3825-7150 143 µM 1.17514770085365 0.113328268508381 no 388 0.119967814771087 686 22330411 YGL099W LSG1
SGTC_592 k241-0073 46.5 µM 1.17496333098061 0.113365172759086 no 389 0.120004693231577 678 4230158
SGTC_693 4161-2696 114 µM 1.17462945234799 0.113432025127357 no 390 0.120071497417305 587 805759
SGTC_1168 k815-0004 80.5 µM 1.17171033846289 0.114017715676061 no 391 0.120656685429443 632 642433
SGTC_1692 fluoroquinolonic acid 71 µM 1.16942167942868 0.114478416248245 no 392 0.121116889723036 634 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_492 tmb-8 126 µM 1.16896849501961 0.114569797935243 no 393 0.121208162449686 470 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_214 4373-3496 70 µM 1.16835022965395 0.11469455083365 no 394 0.121332760988542 815 3779166
SGTC_47 0149-0135 24.25 µM 1.16691097961761 0.114985335436098 no 395 0.121623160712536 608 5239155
SGTC_2228 7354201 200 µM 1.16617717929196 0.115133793342368 no 396 0.121771408614526 627 753451
SGTC_3102 9121669 49.47 µM 1.15973628977422 0.116442723904275 no 397 0.123078095119376 608 41905072
SGTC_714 4296-0578 26.1 µM 1.15943668928072 0.116503865205623 no 398 0.123139114464896 602 1589775
SGTC_877 0771-0151 33.1 µM 1.15844724597239 0.116705948705804 no 399 0.123340784063701 680 6166523
SGTC_128 0906-2981 13.371 µM 1.15751964185977 0.11689562779407 no 400 0.123530059575847 593 6740226
SGTC_11 0438-0307 1.3 µM 1.15564148590063 0.117280347235596 no 401 0.123913915742998 639 4011476
SGTC_3103 9120822 49.47 µM 1.15418543253079 0.117579220147278 no 402 0.124212076808971 687 17141819
SGTC_1090 efavirenz 20.7 µM 1.15404514498356 0.117608044347422 no 403 0.124240830456857 650 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1278 0874-0585 172 µM 1.15312423268701 0.117797383912002 no 404 0.124429698288455 667 766306
SGTC_827 3253-0474 693 µM 1.15262985963831 0.117899115941642 no 405 0.124531170919768 703 5402065
SGTC_2979 9012552 45.46 µM 1.15045864194954 0.118346644814285 no 406 0.124977509532854 601 17100905
SGTC_3025 9087895 49.47 µM 1.14903973016689 0.118639757337029 no 407 0.125269799224437 715 17173641
SGTC_2596 sinensetin 100 µM 1.1474750579599 0.118963574670009 no 408 0.125592667881616 634 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1460 k062-0059 9.15 µM 1.1459023215574 0.119289689389414 no 409 0.125917785277877 657 1373085
SGTC_2162 5663267 200 µM 1.14476530440516 0.119525848162526 no 410 0.126153195658385 701 6456493
SGTC_688 0527-0193 473 µM 1.13991644073115 0.120536660199307 no 411 0.127160557438466 641 4007154
SGTC_976 1348-1067 47.6 µM 1.13719770146231 0.121106045185999 no 412 0.127727823820914 741 5310671 YGL099W LSG1
SGTC_1951 sophoraflavanone G 9.2 µM 1.13601918116225 0.121353449359007 no 413 0.127974268380264 702 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_816 0325-0417 81.3 µM 1.13222294509088 0.122152800129064 no 414 0.128770357941043 650 68101
SGTC_2792 7535235 81.82 µM 1.13173514732279 0.122255780211653 no 415 0.128872900108046 621 1281891
SGTC_2722 naftopidil 47.16 µM 1.13171007808745 0.122261074280291 no 416 0.128878171554747 709 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2877 9040724 71.43 µM 1.12745709801543 0.123161540236808 no 417 0.129774634843955 674 6463895
SGTC_2465 5809242 33.21 µM 1.12730639638585 0.123193532717451 no 418 0.129806479468194 675 2731748
SGTC_3122 9126309 49.47 µM 1.12282514735734 0.124147520435206 no 419 0.130755881438295 665 17591206
SGTC_1741 st038134 10.228 µM 1.12028590426826 0.124690373744209 no 420 0.131295973417283 723 1272587
SGTC_1495 4469-0029 237 µM 1.11861280729036 0.125048963008188 no 421 0.131652678639287 797 793680
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.11754872031967 0.125277399578769 no 422 0.131879890204171 500 4000243
SGTC_462 ag-879 158 µM 1.11523578906887 0.125774940612976 no 423 0.132374696630104 728 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2356 9061756 188.97 µM 1.11275988638335 0.126309064515788 no 424 0.132905783851791 665 20104043
SGTC_2810 7959871 45.46 µM 1.11270008073492 0.126321985848083 no 425 0.132918630431053 739 2974535
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.11109652889207 0.126668785353801 no 426 0.133263400911529 793 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_32 0928-0142 34.1 µM 1.1076777813838 0.12741036871391 no 427 0.134000499155983 678 2244242
SGTC_2940 9060638 45.86 µM 1.10374018874074 0.128268233381046 no 428 0.134852928429436 693 4027022
SGTC_2662 daunorubicin 22.37 µM 1.10240836039273 0.128559298174726 no 429 0.135142089257017 664 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_209 4077-0173 175.592 µM 1.10031411587423 0.129017911946174 no 430 0.135597641941469 587 15993494
SGTC_1430 4049-0248 69.1 µM 1.1002011559911 0.129042680975897 no 431 0.135622243524049 784 22774488
SGTC_1509 1326-1131 80 µM 1.09923673824217 0.129254285806023 no 432 0.135832408987956 673 768313
SGTC_288 1315-0019 35.1 µM 1.09741376483347 0.129654924758175 no 433 0.136230279459644 726 6811474
SGTC_2545 solidagenone 89.61 µM 1.09656941103475 0.129840781441303 no 434 0.136414832665474 470 6708572 An anti ulcer agent
SGTC_3256 9138902 49.47 µM 1.09539998545647 0.130098496515113 no 435 0.136670720242905 735 17228773
SGTC_419 nsc-638432 893 µM 1.09469484879426 0.130254063739214 no 436 0.136825173063157 706 368090
SGTC_1009 4106-0057 9.87 µM 1.09225918106854 0.130792410525805 no 437 0.137359598244566 757 2928005
SGTC_1591 genipin 88.4 µM 1.08892113713407 0.131532701366082 no 438 0.138094332130137 692 442424 A DNA cross-linking agent.
SGTC_894 0960-0238 55.9 µM 1.08516749741952 0.132368609328453 no 439 0.138923738425776 739 6741907 YDL195W SEC31
SGTC_2591 skatole 100 µM 1.08280258566981 0.132897133872622 no 440 0.139448028814373 705 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_335 4077-0256 27.6 µM 1.0820873666497 0.133057261047034 no 441 0.139606854411192 801 3121989
SGTC_2075 5212009 200 µM 1.08196064362999 0.133085646338622 no 442 0.139635008068004 642 780898
SGTC_1653 st012112 65 µM 1.08190144690418 0.133098907522776 no 443 0.139648160942223 682 720429
SGTC_3352 9151559 45.5865 µM 1.07770805669144 0.134040620848982 no 444 0.140582030943062 693 17159339
SGTC_2117 5521686 200 µM 1.07763167151597 0.134057817083301 no 445 0.140599081177229 720 803312
SGTC_1204 4049-0315 18.3 µM 1.07554467446757 0.134528239394817 no 446 0.1410654710594 703 588402
SGTC_2216 7189485 200 µM 1.07546470396612 0.134546287765649 no 447 0.141083363246334 752 731273
SGTC_2347 9049783 174.81 µM 1.07352720778582 0.134984065114468 no 448 0.141517318966286 773 6467988 YPL169C MEX67
SGTC_1963 st076565 50.3 µM 1.07295516443807 0.135113504934735 no 449 0.141645616611587 714 4914280
SGTC_3250 9135583 49.47 µM 1.070872477974 0.13558548630674 no 450 0.142113386171956 700 7699353
SGTC_733 4069-0007 56.1 µM 1.07062944455411 0.135640636394127 no 451 0.1421680393093 792 5717425 YNL287W SEC21
SGTC_609 0986-0026 86.3 µM 1.06956401215751 0.13588258979182 no 452 0.142407800639629 751 2848610
SGTC_1018 4259-0013 28.1 µM 1.06943159401719 0.135912681803285 no 453 0.142437618672402 704 6801262
SGTC_1822 st052468 42 µM 1.06782756427728 0.136277559841648 no 454 0.142799150912788 702 2873678
SGTC_970 1315-0089 19.5 µM 1.06550670600938 0.136806684609734 no 455 0.143323346277592 702 6811083 YLR033W RSC58
SGTC_753 1322-0200 289 µM 1.06192980908295 0.137624916358011 no 456 0.144133775648186 760 5403907
SGTC_657 3534-0529 86.7 µM 1.0609867448974 0.137841201937794 no 457 0.144347962544294 766 1049549
SGTC_912 3474-0017 2.18 µM 1.06065661587532 0.137916969631358 no 458 0.144422991469052 759 3360550
SGTC_306 1672-3436 11.6 µM 1.06020889116448 0.138019772019031 no 459 0.144524788528109 763 6797378
SGTC_1084 voriconazole 435 nM 1.0507585573638 0.140201867097456 no 460 0.146684747028619 769 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2871 9038510 12.99 µM 1.04936380662343 0.140525890609944 no 461 0.147005354719753 791 4945164
SGTC_2002 4023503 131 µM 1.04916272771427 0.140572646438355 no 462 0.147051614928948 862 4736863 YCR052W RSC6
SGTC_2858 9025781 8.96 µM 1.04817584971789 0.140802273105419 no 463 0.147278797563963 853 4894980 YPL153C RAD53
SGTC_2219 9098279 200 µM 1.04814041553756 0.14081052265706 no 464 0.147286959004026 745 902349
SGTC_340 k038-0059 454 µM 1.0478636577503 0.140874966859006 no 465 0.147350714158938 770 23733424
SGTC_2394 5221648 200 µM 1.04655320751427 0.141180382294713 no 466 0.147652846389712 848 788586
SGTC_411 enrofloxacin 100 µM 1.04616124468399 0.141271820878807 no 467 0.147743296348815 771 71188 A bacterial gyrase inhibitor.
SGTC_2357 9067248 200 µM 1.04579338776022 0.141357672456568 no 468 0.147828217336093 709 9150235
SGTC_736 0958-0254 92.6 µM 1.04551465938893 0.14142274648265 no 469 0.147892584461426 789 6812352
SGTC_895 0964-0006 13.7 µM 1.04271874306559 0.142076625373105 no 470 0.148539287255473 754 6738897
SGTC_3193 9111931 49.47 µM 1.04051994974088 0.142592290844028 no 471 0.149049200219615 746 17087244
SGTC_1660 st012960 28.1 µM 1.03950562217996 0.142830599065905 no 472 0.14928482234147 732 24207266
SGTC_1659 st012954 42.1 µM 1.0387640962029 0.143004984958577 no 473 0.149457231595579 740 24207262
SGTC_2456 5770359 74.46 µM 1.03744500679247 0.143315552852868 no 474 0.149764256197048 794 3118787
SGTC_1753 st043925 64 µM 1.03657125045862 0.143521521617502 no 475 0.149967858802667 791 670181
SGTC_1170 0310-0127 64.8 µM 1.03474242687613 0.143953272936668 no 476 0.150394608273292 791 774975
SGTC_1780 st038448 24.544 µM 1.03008019749843 0.145057898723167 no 477 0.151486180109071 768 728868 YDL195W SEC31
SGTC_843 0310-0051 143 µM 1.02830676817298 0.145479572704164 no 478 0.151902774175178 775 2065037
SGTC_1947 st076332 61.6 µM 1.02757417612409 0.145654003843366 no 479 0.152075088392993 730 24208416
SGTC_908 3448-7491 47.7 µM 1.02754942273196 0.145659900113689 no 480 0.15208091294668 831 1203031
SGTC_270 tamoxifen 5.46 µM 1.02744867954034 0.145683898847646 no 481 0.152104619675835 835 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2607 solasodine 47.35 µM 1.02497033673984 0.146275119151523 no 482 0.152688592176186 780 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2170 morpholine 200 µM 1.02435169259371 0.146422950557918 no 483 0.152834595091933 788 121171 Reacts with secondary amines.
SGTC_1477 0139-0234 16 µM 1.02384007347202 0.146545282978568 no 484 0.152955409520938 793 620880
SGTC_2074 5212007 75.395 µM 1.02349702707827 0.146627346654881 no 485 0.153036452410344 729 758611
SGTC_2676 harmalol 100 µM 1.02329396733911 0.146675937202978 no 486 0.153084437604699 812 5459187 A monoamine oxidase inhibitor
SGTC_3288 9119690 36.221 µM 1.02311194535447 0.146719502769922 no 487 0.15312745982771 701 17595618 YKL019W RAM2
SGTC_3285 9112818 20.8695 µM 1.0222324055006 0.146930136218886 no 488 0.153335458387682 828 17017947 YPR165W RHO1
SGTC_52 0329-0193 875 nM 1.01909359772911 0.147683475036234 no 489 0.154079266671581 749 3739292
SGTC_1870 st057514 26.5 µM 1.01610761114819 0.14840253249021 no 490 0.154789072512398 757 5393161
SGTC_1546 5-methoxyflavanone 78.7 µM 1.01494738684485 0.148682557512366 no 491 0.15506545398217 831 147795
SGTC_1632 st005650 90 µM 1.01379789083253 0.148960341320512 no 492 0.155339600971051 758 2759605
SGTC_3273 9137859 49.47 µM 1.01227860204127 0.149328019829682 no 493 0.155702431487646 790 2377234
SGTC_37 0566-0070 1.56 µM 1.0120362249917 0.149386732763876 no 494 0.155760366663145 843 1626686
SGTC_2397 5161689 200 µM 1.01071230725804 0.149707707914619 no 495 0.156077072415009 814 2259942
SGTC_2515 chrysin 20.77 µM 1.00757949744282 0.150469068370508 no 496 0.156828187838918 803 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2528 xanthyletin 44.79 µM 1.00570987301456 0.150924666344989 no 497 0.157277576243206 796 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_356 1634-0012 32.5 µM 1.00327028267899 0.151520535350557 no 498 0.157865235167993 827 735457
SGTC_1976 st070609 63.5 µM 1.00093575802116 0.15209220464057 no 499 0.158428933825081 820 682556
SGTC_3279 9140807 49.47 µM 1.00084812348183 0.152113692101735 no 500 0.158450119904463 809 45595718
SGTC_107 0358-0022 2.6945 µM 1.00020005562595 0.15227265701198 no 501 0.158606851168808 666 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3196 9111891 49.47 µM 0.999823015824121 0.152365192034315 no 502 0.158698082710396 782 18891510
SGTC_3079 9117512 49.47 µM 0.999090129762961 0.152545167419023 no 503 0.158875516051325 875 7185044
SGTC_1558 st069300 45.6 µM 0.997593060103872 0.152913242139905 no 504 0.159238363833038 740 24208000
SGTC_2206 7254556 146.969 µM 0.996481627702869 0.153186883312966 no 505 0.159508094693208 790 4398905
SGTC_1656 st012921 11 µM 0.995286417407118 0.153481513005887 no 506 0.159798490952519 752 6732821
SGTC_1411 3909-8223 150 µM 0.995214243004704 0.153499316629774 no 507 0.159816037993011 856 X1411
SGTC_1210 3013-0140 750 nM 0.994133880710731 0.153765978513995 no 508 0.160078846312405 868 905973
SGTC_82 0054-0107 293.755 µM 0.992314529630358 0.154215734929616 no 509 0.160522058871044 816 3104697
SGTC_95 0471-0001 561.058 µM 0.990808159325521 0.154588778053836 no 510 0.16088963218031 767 4015405
SGTC_2058 5236698 133 µM 0.98834645502871 0.155199686248063 no 511 0.161491500709104 785 766665
SGTC_2270 7924575 90.91 µM 0.986144650970497 0.155747444717706 no 512 0.162031067673727 847 1262135
SGTC_832 4083-0019 164 µM 0.984490702551155 0.156159746706687 no 513 0.162437150315924 984 1990758
SGTC_2684 capsaicin 100 µM 0.982740494328722 0.156596827119381 no 514 0.16286758762252 788 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_709 3807-1509 243 µM 0.981568541908744 0.156889949170749 no 515 0.163156225847734 818 1886677 YPL242C IQG1
SGTC_3053 9095903 49.47 µM 0.978964496604881 0.157542549524597 no 516 0.163798761067703 853 17174018
SGTC_501 nsc-95397 161 µM 0.977659234102055 0.157870331816307 no 517 0.164121445179271 808 262093
SGTC_2264 7948757 110.76 µM 0.973204998466375 0.15899226518837 no 518 0.165225713532235 792 2971411
SGTC_1292 0kpi-0043 232 µM 0.970246979149135 0.159740211156813 no 519 0.165961699403258 792 3333905
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.969741819874897 0.159868172294066 no 520 0.166087599747174 867 23847180
SGTC_366 0181-0206 4.31 µM 0.967700696964952 0.160385888670279 no 521 0.166596934974334 874 274874
SGTC_3063 1327-0034 4 µM 0.966695808484695 0.160641173524078 no 522 0.166848061546463 811 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1044 1222-0021 1.78 µM 0.963772084985094 0.161385433416646 no 523 0.167580102463884 820 4306703
SGTC_2957 9076800 11.52 µM 0.962469855528238 0.161717650249351 no 524 0.167906819185727 753 16459615
SGTC_2832 7992762 51.95 µM 0.962214910508889 0.161782742400941 no 525 0.167970830377981 715 2985177
SGTC_2893 9048488 25.97 µM 0.96114623905479 0.162055779626671 no 526 0.168239321600758 816 6467338
SGTC_3099 9120367 49.47 µM 0.960881867230687 0.162123370845374 no 527 0.168305784507473 847 24824940
SGTC_6 0844-0013 19.835 µM 0.958180882040075 0.162814976039993 no 528 0.168985777901928 1041 1584900
SGTC_3023 9089636 49.47 µM 0.956968300425146 0.163126088726839 no 529 0.169291627614111 896 17249241
SGTC_275 trichlorophene 5.69 µM 0.956780273868634 0.163174365374642 no 530 0.169339085394262 950 62616
SGTC_2316 5844804 197.44 µM 0.955779771168024 0.163431404982619 no 531 0.169591755213925 997 776813
SGTC_995 3931-2021 34.6 µM 0.955650803527717 0.16346455724302 no 532 0.169624342660312 820 730143
SGTC_503 tyrphostin 8 294 µM 0.954135757826117 0.163854340002783 no 533 0.170007464000142 847 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2283 7944793 200 µM 0.953815680584099 0.163936764857322 no 534 0.170088475326621 850 2970533
SGTC_1087 pterostilbene 9.05 µM 0.952096644707459 0.164379903425815 no 535 0.170523985260941 874 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1851 st056236 18.9 µM 0.948554083123824 0.165295563003002 no 536 0.171423726871863 893 5393171
SGTC_2482 5981709 142.65 µM 0.945099184064417 0.166191737007476 no 537 0.172304120927942 864 877755
SGTC_2537 larixol 68.93 µM 0.940821089988722 0.167305782292578 no 538 0.173398275596853 911 6708759
SGTC_1092 toremifene 6.32 µM 0.940539350652596 0.167379317702162 no 539 0.173470487444802 942 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2990 9074105 71.4286 µM 0.940502596966442 0.167388912137986 no 540 0.173479909093929 842 6502001
SGTC_2589 lobaric acid 100 µM 0.940307004870264 0.167439976809504 no 541 0.173530053763574 831 73157 A novel microtubule depolymerizer.
SGTC_351 caspofungin 25 nM 0.939981689137599 0.167524931616175 no 542 0.173613476589622 972 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1396 3511-0007 98.6 µM 0.93930327127491 0.16770218684684 no 543 0.173787529769499 779 X1396
SGTC_2224 6650123 117.647 µM 0.939001568548698 0.167781053725517 no 544 0.173864969504017 838 2908370
SGTC_2992 9074591 71.4286 µM 0.938073714202721 0.168023749974875 no 545 0.174103264593176 830 17741321
SGTC_80 0159-0065 512.242 µM 0.937362885812751 0.168209832122624 no 546 0.174285962625898 797 1548079
SGTC_861 0443-0273 110 µM 0.93558816579924 0.168675000522338 no 547 0.174742634985352 886 6149169
SGTC_1956 st077085 54 µM 0.933528711147916 0.169215835535415 no 548 0.175273526768008 892 24208685
SGTC_3280 9140961 49.47 µM 0.932856840711829 0.169392516549588 no 549 0.175446944375936 834 4901226
SGTC_549 1661-1316 519 µM 0.931924565180017 0.16963787204409 no 550 0.17568775568011 913 2857282
SGTC_958 1222-0007 33 µM 0.931786342455787 0.169674268780862 no 551 0.175723477099834 921 7312461
SGTC_2304 7443016 91.4 µM 0.930334107490798 0.170056973284686 no 552 0.176099061753286 799 939854
SGTC_1892 st058411 7.36 µM 0.929955822427568 0.170156752727941 no 553 0.176196979194301 934 3934738
SGTC_1244 0416-0015 52.5 µM 0.929281828463471 0.17033462362281 no 554 0.17637152497127 863 96201
SGTC_3015 9080845 49.47 µM 0.928064196635769 0.170656265516579 no 555 0.17668713513807 946 5296973
SGTC_1067 clotrimazole 1.36 µM 0.926235204089889 0.171140130686003 no 556 0.1771618805743 893 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.924854658108874 0.171505938517929 no 557 0.177520757349139 972 6708784 An antioxidant flavonoid
SGTC_2007 4011539 71.82 µM 0.924847628136539 0.171507802550696 no 558 0.177522585983466 861 45595301
SGTC_1530 rhein 70.4 µM 0.922627304340676 0.172097180368368 no 559 0.178100730751835 955 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_758 0868-0029 16 µM 0.921356537185001 0.172435082392181 no 560 0.178432156223358 915 762687
SGTC_942 3253-1115 227 µM 0.920347835646169 0.172703601182972 no 561 0.178695509467173 895 46497897
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.920203469657371 0.17274205355196 no 562 0.178733220756161 837 5282362
SGTC_1751 st044839 27.194 µM 0.919619621303748 0.17289761919283 no 563 0.178885784746912 884 5291326
SGTC_1206 3978-0017 132 µM 0.917781290971058 0.173388022791724 no 564 0.179366689480553 839 3873677
SGTC_1688 st021091 57.6 µM 0.917134316794643 0.173560823798966 no 565 0.179536130251868 919 3656366
SGTC_1950 st077106 7.18 µM 0.915210954830014 0.174075183459476 no 566 0.180040447358347 893 13831864
SGTC_1322 1348-1070 12 µM 0.914765205249114 0.174194527273409 no 567 0.180157452419159 882 6758089
SGTC_2395 5646831 180.19 µM 0.912514477965336 0.174797924942142 no 568 0.180748975812625 881 6808628
SGTC_1784 st039334 36.3 µM 0.91228497441242 0.174859527019862 no 569 0.180809360970654 886 3496984
SGTC_1008 4106-0037 6 µM 0.910724417609743 0.175278768371702 no 570 0.181220297595668 912 2905394
SGTC_2249 haloperidol 116.36 µM 0.908065224897594 0.17599462375658 no 571 0.181921881015893 995 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1716 st033144 30.6155 µM 0.904332889489428 0.177002487101907 no 572 0.182909456001696 941 674617
SGTC_691 1548-0686 185 µM 0.903516703650916 0.177223371317373 no 573 0.183125863568931 897 46495133
SGTC_2924 9010168 62.78 µM 0.903365739739187 0.177264245721275 no 574 0.183165908386222 899 2993929
SGTC_1452 4194-0072 190 µM 0.903232320361932 0.177300374790341 no 575 0.183201303871502 982 1343545
SGTC_1111 tnp00062 510.699 nM 0.902923192394848 0.177384102428852 no 576 0.183283330347498 960 676306
SGTC_153 4077-0274 519.67 µM 0.901336222250399 0.177814327913414 no 577 0.183704790127012 874 3121976
SGTC_2100 5377183 190 µM 0.901172346228855 0.177858791946942 no 578 0.18374834588891 985 2844202
SGTC_3241 9133421 49.47 µM 0.899091027362415 0.178424120529452 no 579 0.184302088483417 926 17018221
SGTC_2011 4012611 177 µM 0.898874106060923 0.178483105842615 no 580 0.184359860889635 915 2049887
SGTC_2319 6033012 152.6 µM 0.898775602227081 0.178509895093094 no 581 0.184386099024381 829 847246
SGTC_1124 fisetin 1.16336 µM 0.897336974864673 0.178901434915864 no 582 0.18476956604404 868 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_236 1509-0011 5.31 µM 0.895785286422074 0.179324351060804 no 583 0.185183724834228 1077 3107280
SGTC_1245 0418-0076 17.2 µM 0.89403279428052 0.179802751979684 no 584 0.185652172542777 894 6790114
SGTC_533 1222-0222 6.71 µM 0.893149107163734 0.180044287494081 no 585 0.185888664009632 951 3982874
SGTC_897 1000-0139 31.4 µM 0.892699754009443 0.18016718592198 no 586 0.186008991072536 917 6151020
SGTC_193 1273-0060 1.558 µM 0.89243924108722 0.180238460511313 no 587 0.186078772910699 814 2847393 YHR072W ERG7
SGTC_1675 st018485 24.5 µM 0.89093750621623 0.180649670054047 no 588 0.186481348818189 911 3323024
SGTC_480 am 92016 50 µM 0.889083978223521 0.181158019081927 no 589 0.186978974425382 871 2129 K+ channel blocker.
SGTC_1198 1612-1005 86.7 µM 0.888908355314061 0.181206231892091 no 590 0.187026167327898 937 6998509
SGTC_2883 9059145 45.46 µM 0.88795194209232 0.181468931887902 no 591 0.18728330135474 892 16476510
SGTC_1811 st050069 61.5 µM 0.88640087932828 0.181895472028485 no 592 0.187700772773034 933 3877702
SGTC_3134 9127454 49.47 µM 0.885448115945155 0.182157791273942 no 593 0.187957495581718 964 24262820
SGTC_2293 7624732 200 µM 0.884930400295533 0.182300430259787 no 594 0.18809708530967 890 894453
SGTC_2857 9024691 58.44 µM 0.883870369669503 0.182592703426654 no 595 0.188383096951385 901 16478292
SGTC_3062 9077494 49.47 µM 0.883853597773752 0.182597330148253 no 596 0.188387624406864 899 16459633
SGTC_999 SEC7.066 22.7 µM 0.883079687662826 0.182810901838797 no 597 0.188596609001215 987 740511 YDR170C SEC7
SGTC_1 0258-0098 57.368 µM 0.882146332103718 0.183068682139346 no 598 0.188848839870664 812 6790032 YDR047W HEM12
SGTC_491 tetrandrine 80.3 µM 0.881059933387291 0.183369016353486 no 599 0.189142690915672 899 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_191 3914-0123 66.505 µM 0.879261701232385 0.18386681106355 no 600 0.189629698272496 804 3144412
SGTC_49 0717-0965 32.132 µM 0.878121221655986 0.184182959494007 no 601 0.189938968756331 1008 5889349 YGL099W LSG1
SGTC_3201 9113999 49.47 µM 0.87797183265281 0.184224396154033 no 602 0.189979502397605 880 16649224
SGTC_2306 7482397 179.52 µM 0.877771281259769 0.184280033064103 no 603 0.190033926263526 934 891448
SGTC_76 0433-0009 400.328 µM 0.876186559673686 0.184720033727051 no 604 0.190464310956936 833 2841569
SGTC_1308 1187-1617 41.4 µM 0.875346181657548 0.184953630912259 no 605 0.190692786666719 969 2882570
SGTC_3294 9122953 26.2835 µM 0.871052794807046 0.186149912170558 no 606 0.191862663541861 1003 16459826
SGTC_2044 5102272 200 µM 0.870750024295225 0.186234454801687 no 607 0.191945329010499 872 592666
SGTC_1899 st063254 59.6 µM 0.870745223902934 0.186235795407143 no 608 0.19194663983771 849 3093813
SGTC_2760 etidronate 98.04 µM 0.866946692830409 0.187298485105873 no 609 0.192985609073138 935 3305 A chelator and antioxidant.
SGTC_1885 st057546 99.9 µM 0.864335441221129 0.188031187525223 no 610 0.193701823138521 991 702008
SGTC_2427 5545055 42.75 µM 0.863567685956327 0.188246951442486 no 611 0.193912710956806 1001 5372858
SGTC_2733 amorolfine 100 µM 0.861097741608952 0.188942120871742 no 612 0.19459210646545 942 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2939 9044578 71.43 µM 0.859306906969087 0.189447141624282 no 613 0.195085607266514 935 2653634
SGTC_151 3013-0144 2.285 µM 0.857947016343024 0.189831189235582 no 614 0.195460860418582 950 906558 YHR107C CDC12
SGTC_2245 6637752 200 µM 0.857047585262012 0.190085460989707 no 615 0.195709293390556 902 681890
SGTC_3013 9080133 71.4286 µM 0.856331418327638 0.190288073050624 no 616 0.195907243751749 1011 17050193
SGTC_1981 st071826 47 µM 0.855658137285535 0.190478673123615 no 617 0.196093451089208 901 11838600
SGTC_3335 9143315 29.6265 µM 0.854020991842311 0.190942623769799 no 618 0.196546679182969 938 4899691
SGTC_312 4092-0653 6.84 µM 0.853050230992494 0.191218054777217 no 619 0.196815724567593 1027 1148278
SGTC_406 estrone 100 µM 0.852235072829034 0.191449525140779 no 620 0.19704181699202 989 5870 A steroid.
SGTC_2798 7813637 45.45 µM 0.850867752092826 0.191838171583213 no 621 0.197421410125735 939 956368
SGTC_921 1561-0023 372 µM 0.848388397073504 0.192544132903417 no 622 0.198110851174794 1027 24050882
SGTC_3233 9132340 49.47 µM 0.844677509134136 0.193603718378035 no 623 0.19914546006205 979 17682950
SGTC_3077 9117319 49.47 µM 0.842654481931413 0.194182856643886 no 624 0.199710855595508 976 17154678
SGTC_1481 3346-2004 36 µM 0.842509224110199 0.194224480612672 no 625 0.19975148937053 1016 2770522
SGTC_36 0335-0881 14.2 µM 0.841894212779989 0.194400773748743 no 626 0.199923584996228 994 23828853
SGTC_3274 9138298 49.47 µM 0.840476665206998 0.194807484951324 no 627 0.200320589873986 1018 17015756
SGTC_1336 1486-0901 104 µM 0.839171533736692 0.195182399879828 no 628 0.200686529456642 968 5006114
SGTC_2830 7992007 71.43 µM 0.8387808742184 0.19529470680568 no 629 0.200796142602678 940 1952075
SGTC_698 k064-0052 127 µM 0.838507416879188 0.195373343766543 no 630 0.200872891966172 1006 5088751
SGTC_1696 st025591 34.7925 µM 0.838111109054194 0.195487342449972 no 631 0.200984152154774 996 2787147
SGTC_362 0310-0100 9.03 µM 0.835204665164314 0.196324620347682 no 632 0.201801241734109 968 790235
SGTC_1293 1000-1278 195 µM 0.834529851522794 0.196519328743554 no 633 0.201991236468422 1007 678847
SGTC_2374 9071832 200 µM 0.834015931916692 0.196667691789347 no 634 0.202136003052356 969 17381698
SGTC_3347 9188721 44.724 µM 0.833928644526051 0.196692897456023 no 635 0.202160597300326 950 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_255 tunicamycin 200.472 nM 0.833439116899786 0.196834292847179 no 636 0.202298560634487 991 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2218 6965428 192.983 µM 0.833190950055022 0.19690599697936 no 637 0.20236852288195 996 675684
SGTC_500 h-89 112 µM 0.832232969416799 0.197182939603156 no 638 0.202638728824455 1037 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3087 9117406 49.47 µM 0.830491118048652 0.19768709485425 no 639 0.203130583764205 973 42546093
SGTC_3154 9100113 49.47 µM 0.829665488019259 0.197926334163972 no 640 0.20336396964636 991 25237525
SGTC_875 0709-0210 25.7 µM 0.824482731651799 0.199432110141525 no 641 0.204832661859103 1089 6251364
SGTC_659 k018-0002 107 µM 0.823677045206631 0.199666808671781 no 642 0.205061542870546 1013 6797879 YHR007C ERG11
SGTC_383 2324-0395 7.37 µM 0.823180132793667 0.199811643354471 no 643 0.205202782496393 1021 3146421
SGTC_244 nsc-207895 1.295 µM 0.821371153364805 0.200339438742627 no 644 0.205717444777036 887 42640
SGTC_3126 9127922 49.47 µM 0.82007189943174 0.200719030797211 no 645 0.206087560237755 1009 45595682
SGTC_2805 7950783 58.44 µM 0.819657068044928 0.200840319450978 no 646 0.206205815404453 1025 1178958 YDL195W SEC31
SGTC_1093 fluphenazine 7.97 µM 0.819611336735815 0.20085369309006 no 647 0.206218854399912 1057 6602611 An atypical antipsychotic.
SGTC_823 0417-1665 178 µM 0.818697304584622 0.201121104218787 no 648 0.206479567430303 1019 3429856
SGTC_3080 9117754 49.47 µM 0.817815302821469 0.201379346787256 no 649 0.206731329335906 1055 9550191
SGTC_904 1141-0088 396 µM 0.817753080254357 0.201397572524301 no 650 0.206749097240624 1004 1378119
SGTC_2429 5902844 64.44 µM 0.817629867316235 0.201433665990367 no 651 0.206784283859201 1044 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1465 k213-0056 144 µM 0.817400355063508 0.201500908653613 no 652 0.206849836428431 953 24048857 YMR208W ERG12
SGTC_446 go6976 132 µM 0.816329410952514 0.201814852389057 no 653 0.207155878694704 1006 3501 A protein kinase C inhibitor.
SGTC_1363 1636-0063 10.4 µM 0.816181828442195 0.201858138665267 no 654 0.207198074138974 1051 6072185
SGTC_1215 3852-0577 11.2 µM 0.815234664016485 0.2021360763743 no 655 0.20746899972393 1086 2884876
SGTC_2755 lomerizine 42.69 µM 0.813266006739346 0.202714494938019 no 656 0.208032781137725 1049 3949 A calcium channel blocker.
SGTC_2453 5731132 22.18 µM 0.81301846421916 0.202787296269437 no 657 0.20810373598241 1055 1362040
SGTC_2244 6635614 200 µM 0.811878027748937 0.203122896083614 no 658 0.208430811704103 866 836499
SGTC_15 0266-0086 27.098 µM 0.811323420998891 0.203286221711675 no 659 0.208589981717665 1114 1712902 YIL048W NEO1
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.811192347080857 0.203324832995251 no 660 0.208627609896741 1202 16725076
SGTC_389 tpck 16.7 µM 0.808485929517617 0.204123057406508 no 661 0.20940545137951 1006 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1034 k072-0165 12.7 µM 0.808291792731333 0.204180387311428 no 662 0.209461313034381 1046 5835461
SGTC_1285 0929-0069 65.5 µM 0.807876188013849 0.204303150427385 no 663 0.209580930182089 1008 1206237
SGTC_1101 ebselen 5.29 µM 0.80429919384333 0.205361554021646 no 664 0.210612101572122 1112 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_222 nsc-310342 10.666 µM 0.804274846984942 0.205368769200703 no 665 0.21061913043882 1003 432556
SGTC_3005 9076496 71.4286 µM 0.803523993789552 0.205591358075773 no 666 0.210835967125283 1015 21368410
SGTC_106 0092-0003 11.579 µM 0.802607898105407 0.205863126618419 no 667 0.21110070093129 1004 1072148
SGTC_163 TUB2.036 7.546 µM 0.801686631730978 0.206136643919153 no 668 0.211367125338831 1104 15992207 YJR013W GPI14
SGTC_1674 st016616 23.6 µM 0.801576154121437 0.206169458381749 no 669 0.211399087984349 1045 625830
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.801191624109829 0.206283697034307 no 670 0.211510359715173 973 15053
SGTC_2885 9057732 51.95 µM 0.80034713880957 0.206534713800403 no 671 0.211754849367109 1070 6471414
SGTC_1253 0550-0034 176 µM 0.799920742605181 0.206661525508113 no 672 0.211878359509067 986 5969915
SGTC_2712 st079126 47.7 µM 0.799731771851982 0.206717740806529 no 673 0.211933110348653 1019 3152970
SGTC_2654 protoveratrine a 100 µM 0.798738859992247 0.207013262427138 no 674 0.212220924454337 1052 5702278 A heart drug and vasodilator.
SGTC_650 1328-0195 38 µM 0.797703300074161 0.207321743601302 no 675 0.212521344169475 1056 2780821
SGTC_628 1636-0253 16 µM 0.797317865108877 0.207436629537256 no 676 0.212633223666918 1050 4456143
SGTC_1734 st037168 69.4 µM 0.797114290512431 0.207497323850623 no 677 0.212692328768025 972 708907
SGTC_2436 5633522 8.09 µM 0.796726952646963 0.207612834851427 no 678 0.212804813508869 1064 5724242
SGTC_259 usnic acid 108.925 µM 0.796301004685551 0.20773990392083 no 679 0.212928550885277 1073 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1077 5-fluorocytosine 377 nM 0.796163847298368 0.207780830576891 no 680 0.212968403878171 1009 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1627 st003713 25.6 µM 0.79592602752766 0.207851805361468 no 681 0.213037516046705 1098 16195070 YER133W GLC7
SGTC_2251 lansoprazole 556 µM 0.795373558799514 0.208016739037355 no 682 0.213198118005247 872 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2694 st077685 81.9 µM 0.790895256887229 0.209356537402139 no 683 0.214502558226493 1057 2838096
SGTC_1458 k015-0034 6.33 µM 0.79011319666443 0.209591030452704 no 684 0.214730831787747 1027 3598957
SGTC_2772 vinpocetine 57.06 µM 0.790062165776271 0.209606336928664 no 685 0.21474573196776 1032 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1578 josamycin 24.2 µM 0.790027844597838 0.209616631775201 no 686 0.214755753525256 978 5282165 A P450 substrate.
SGTC_3325 9138760 55.175 µM 0.789305690625782 0.209833315206852 no 687 0.214966680721098 1032 43844959
SGTC_901 1112-0062 60.1 µM 0.788662761569733 0.21002633782549 no 688 0.215154569050009 1088 1908457
SGTC_1288 0973-0013 65.5 µM 0.786584373991432 0.210651032619398 no 689 0.215762604767146 1079 4315430
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.784400210421265 0.211308693509691 no 690 0.216402657487768 1124 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3022 9087993 49.47 µM 0.782813338303747 0.211787260901555 no 691 0.216868366859564 1073 17173644
SGTC_2225 6654152 15.4 µM 0.782032514971467 0.21202297348171 no 692 0.217097732532736 1024 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_363 0455-0021 3.06 µM 0.781454744830022 0.21219748770139 no 693 0.217267541828942 1063 4597466
SGTC_189 3970-0742 2.116 µM 0.781396405865887 0.212215113525291 no 694 0.217284692181153 1079 2891807
SGTC_3019 9081971 49.47 µM 0.780863545767223 0.212376144987585 no 695 0.217441377327311 1099 16451803
SGTC_764 1951-2361 146 µM 0.780753113780947 0.212409526700043 no 696 0.217473857520569 1023 5438930
SGTC_1248 0469-0687 58.6 µM 0.780151071037002 0.212591567896622 no 697 0.217650979239292 1053 4017482
SGTC_309 k408-0051 1.48 µM 0.780090646340056 0.212609843696164 no 698 0.217668760855048 1079 3640463
SGTC_2904 7225135 42.03 µM 0.779676052526445 0.21273526473975 no 699 0.217790789001064 1117 4446116
SGTC_2934 9036370 36.88 µM 0.776703523004761 0.213635765203852 no 700 0.218666853930727 1092 6462800
SGTC_1127 asiatic acid 681.4 nM 0.776608613928207 0.213664553572022 no 701 0.218694858942518 1016 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_982 1491-0518 27.5 µM 0.776461821064707 0.213709084079998 no 702 0.218738177472849 1012 3091256
SGTC_2735 sertaconazole 140 nM 0.775672873741507 0.213948508636692 no 703 0.218971080167599 1078 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1325 1431-0015 227 µM 0.775004528458207 0.214151455796921 no 704 0.219168491856556 1027 1103340
SGTC_638 3970-0837 4.09 µM 0.774218774596761 0.214390197999762 no 705 0.219400713770748 1070 4118451 YLR208W SEC13
SGTC_2179 6298986 200 µM 0.772429761631826 0.214934345881539 no 706 0.219929966216872 1016 738374
SGTC_1565 sinapyl alcohol 95.1 µM 0.771197364879752 0.215309659006402 no 707 0.220294977944761 1087 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2068 5226020 147 µM 0.768531475747343 0.21612282656315 no 708 0.221085749125516 1152 1810509
SGTC_2095 5432005 200 µM 0.765341356651959 0.217098232029081 no 709 0.22203415171825 1070 783734
SGTC_3302 9125395 16.351 µM 0.765003237412897 0.217201763672494 no 710 0.222134808421987 1055 17599668
SGTC_2093 5331342 194.4 µM 0.762610663495819 0.217935180975142 no 711 0.222847811585157 1112 33839
SGTC_75 0159-0059 199.013 µM 0.760476566446651 0.218590568305126 no 712 0.223484885673313 1072 5377270
SGTC_1908 st060353 56.5 µM 0.759727007784521 0.218821028901313 no 713 0.223708890741258 1114 4227716
SGTC_1906 st060206 94.7 µM 0.759585761874703 0.218864472261144 no 714 0.223751116269277 1131 5133468
SGTC_1239 0337-0584 35.4 µM 0.758485905870506 0.219202927456895 no 715 0.224080073680042 1141 914301 YML130C ERO1
SGTC_1490 4089-0339 670 nM 0.757830183424181 0.219404853922355 no 716 0.224276325228751 1073 742542
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.757571164712009 0.219484646884315 no 717 0.224353873966798 1144 1377
SGTC_947 3447-0010 211 µM 0.756633358521918 0.21977368562414 no 718 0.224634775120473 1146 748350
SGTC_59 0330-0160 1.33 µM 0.755516632973897 0.220118153468723 no 719 0.224969528074554 1136 4293482
SGTC_2570 licareol 100 µM 0.753629116914003 0.220701084711725 no 720 0.225535977771725 1037 443158
SGTC_2821 7996764 71.43 µM 0.75360152289832 0.220709613265336 no 721 0.225544264807739 1181 2987135
SGTC_2652 actinonin 100 µM 0.752779865704328 0.220963651452854 no 722 0.225791103884389 1103 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1364 1653-0028 37.6 µM 0.750842051191837 0.221563443103442 no 723 0.226373859326899 1068 5718652
SGTC_3123 9126162 49.47 µM 0.749875796762779 0.221862865169387 no 724 0.226664756362803 1195 25239884
SGTC_2594 a-mangostin 100 µM 0.748688540660939 0.22223108727964 no 725 0.227022476050254 1115 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2450 5739737 12.93 µM 0.748583394646523 0.222263714641419 no 726 0.227054171830545 1082 2262825
SGTC_1799 st045822 46.1415 µM 0.747953758861467 0.222459151118705 no 727 0.227244024825381 1112 3674992
SGTC_172 1112-0046 2.638 µM 0.745352863345252 0.223267496669909 no 728 0.228029215709417 1015 2802135 YIL048W NEO1
SGTC_3345 9148410 3.559 µM 0.745300988960366 0.223283635959992 no 729 0.22804489170305 1086 4903596
SGTC_2457 5731572 11.68 µM 0.743953422074448 0.22370312698583 no 730 0.228452327160733 1173 2865357
SGTC_46 0329-0187a 2.197 µM 0.742509029766548 0.224153256417421 no 731 0.228889491446413 1139 46494817
SGTC_2889 9059656 51.95 µM 0.742291630980244 0.224221050935743 no 732 0.228955330667936 1165 3949838
SGTC_1000 4048-0884 8.67 µM 0.742029785244337 0.224302721425442 no 733 0.229034644754028 1082 13040088
SGTC_1297 1068-0111 14.1 µM 0.740944849348314 0.224641296161644 no 734 0.229363440230725 1105 767057
SGTC_3344 9148862 3.898 µM 0.739290527129616 0.225158116247212 no 735 0.229865300125871 1144 4905352
SGTC_2243 6634756 200 µM 0.73721915279165 0.225806174569797 no 736 0.230494543987201 1126 885676
SGTC_2018 5133068 143 µM 0.736561858994715 0.226012038377385 no 737 0.230694418302952 1107 785362
SGTC_3268 9137683 49.47 µM 0.73485387725783 0.226547472413158 no 738 0.231214245300412 1122 1953228
SGTC_2783 7738165 71.43 µM 0.734320936131769 0.226714690232712 no 739 0.231376580461351 1070 17201110
SGTC_1769 st044406 64.4 µM 0.730743335304197 0.22783901452878 no 740 0.232467970305729 1131 670903
SGTC_251 melphalan 456.522 µM 0.730283948039529 0.227983612058239 no 741 0.232608318991745 1213 460612 A DNA alkylator.
SGTC_1767 st044992 70.3 µM 0.730012516376127 0.228069072612755 no 742 0.232691266970755 1139 9600693
SGTC_3308 9128332 17.569 µM 0.729689865132195 0.228170683140302 no 743 0.232789888746265 1167 17332805 YDL196W YDL196W
SGTC_3234 9132280 49.47 µM 0.729608932662535 0.228196174686478 no 744 0.232814630257333 1157 17612295
SGTC_495 decylubiquinone 155 µM 0.727272251030425 0.22893285651191 no 745 0.233529596699842 1121 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_587 k089-0003 57 µM 0.726967834087646 0.229028927707245 no 746 0.233622830281113 1095 9659696
SGTC_1514 1189-1591 158 µM 0.726473640157539 0.229184938932819 no 747 0.233774230677376 1154 767698 YMR146C TIF34
SGTC_1752 st044819 83.042 µM 0.725582220434698 0.229466500329187 no 748 0.234047461941883 1119 441209 YML126C ERG13
SGTC_1909 st060837 51.5 µM 0.72468458612754 0.229750220420581 no 749 0.234322776689404 1103 678937
SGTC_928 2764-0428 58.7 µM 0.724075917857118 0.229942717179171 no 750 0.234509564167924 1134 662578
SGTC_743 1275-0778 158 µM 0.724029076675386 0.229957534859865 no 751 0.234523942153033 1153 2849257 YMR203W TOM40
SGTC_837 0091-0265 12.5 µM 0.722128514774668 0.230559206803472 no 752 0.235107734168338 1128 759367
SGTC_3237 9133362 49.47 µM 0.721639624064197 0.230714119920198 no 753 0.235258035495335 1109 43845137
SGTC_2351 9026858 72.31 µM 0.718926133409459 0.231574990514797 no 754 0.236093216735992 1123 1409300
SGTC_1373 2887-0003 58.5 µM 0.717430351613956 0.232050300397462 no 755 0.236554298650948 1138 776948
SGTC_455 paf C-16 10 µM 0.71391020604855 0.233171026202584 no 756 0.237641352975516 1160 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2277 7947813 106.88 µM 0.711479164372026 0.233946759462019 no 757 0.238393678874523 1168 1246798
SGTC_110 0850-0284 111.64 µM 0.711044087788941 0.234085740909633 no 758 0.238528457952857 1042 3906265
SGTC_2534 helenine 20.12 µM 0.71095587637842 0.234113924855148 no 759 0.238555789382392 1175 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1078 idebenone 36.1 µM 0.710894320510353 0.234133593347143 no 760 0.238574862872246 1187 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3101 9120531 49.47 µM 0.710361332797541 0.234303933230513 no 761 0.238740047512145 1210 24824904
SGTC_1507 4075-3230 155 µM 0.710052773237824 0.234402578476293 no 762 0.23883570551139 1103 659771
SGTC_2165 5727197 32.143 µM 0.709645814906306 0.234532716547742 no 763 0.238961900628018 1285 1361712
SGTC_1425 4048-4433 7.33 µM 0.709369892541623 0.234620974366786 no 764 0.239047483083836 1221 23734946
SGTC_1464 k208-0027 110 µM 0.709126199711967 0.234698938368405 no 765 0.239123082881552 1165 X1464
SGTC_60 0986-0278 202 µM 0.709008798898847 0.234736503211897 no 766 0.239159508303668 1028 3110598
SGTC_2483 5729050 27.16 µM 0.708554053292641 0.234882039941636 no 767 0.239300628793442 1192 2865180
SGTC_3210 9128157 49.47 µM 0.708481978619796 0.234905111288799 no 768 0.239322999789066 1128 17590849
SGTC_2141 5621638 7.665 µM 0.706487368617644 0.235544089371933 no 769 0.239942552587459 1182 2856238
SGTC_2493 resveratrol 26.09 µM 0.706030298099818 0.235690647938628 no 770 0.240084647946895 1107 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1657 st012939 43.4 µM 0.705762059055736 0.235776681557919 no 771 0.240168060206507 1190 24207257
SGTC_1026 k007-1105 30.6 µM 0.705287852171384 0.235928818604652 no 772 0.240315559357818 1174 7066794
SGTC_458 nppb 133 µM 0.704456251395783 0.236195746853491 no 773 0.2405743428142 1194 4549 A chloride channel blocker.
SGTC_2714 st079313 56.9 µM 0.703707204387284 0.236436319208202 no 774 0.240807566416164 1171 2939799
SGTC_2408 sulbentine 18.36 µM 0.703025891313685 0.236655254448632 no 775 0.241019807142804 1139 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_298 1391-0729 10 µM 0.702214989826478 0.236915977324171 no 776 0.241272549416162 1156 3237558
SGTC_2563 tomatine 8.54 µM 0.70215339776661 0.236935786992517 no 777 0.241291752350735 1186 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_814 3342-0569 96 µM 0.701327505933189 0.237201504033884 no 778 0.241549325932616 1217 4346283
SGTC_538 2922-0838 53.3 µM 0.700590577248686 0.237438736782674 no 779 0.241779280277615 1225 777039
SGTC_1628 st004252 77.7 µM 0.698065792258374 0.238252504584775 no 780 0.242568024873093 1172 692968
SGTC_1294 1000-1494 117 µM 0.697513179510495 0.238430821733491 no 781 0.242740847166029 1181 712797 YDL207W GLE1
SGTC_1636 st007707 68.9 µM 0.69685847467774 0.238642176507588 no 782 0.242945683628335 1211 403051
SGTC_2016 5121758 140 µM 0.696322868799067 0.238815159438501 no 783 0.243113327307273 1207 2795203
SGTC_2041 5107442 45.335 µM 0.696289349422999 0.238825987365026 no 784 0.243123820891346 1207 793005
SGTC_197 4544-0043 41.561 µM 0.695699826700539 0.239016467633809 no 785 0.243308417045891 1200 896523
SGTC_2826 7992541 19.48 µM 0.694613077339946 0.239367824021489 no 786 0.243648907291007 1265 2985066
SGTC_1073 triclabendazole 3.09 µM 0.694020996113555 0.239559368157013 no 787 0.243834520914055 1250 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1486 3970-0793 4.53 µM 0.692678571897161 0.239993965436967 no 788 0.24425564470954 1221 2844330
SGTC_1422 4031-0024 15.5 µM 0.691583423226889 0.240348827754846 no 789 0.244599487375667 1163 782427
SGTC_2057 5236571 38.335 µM 0.691446092364332 0.240393347397789 no 790 0.244642623388194 1201 54684039 YBR257W POP4
SGTC_1560 lithocholic acid 53.1 µM 0.690680280795411 0.240641688996846 no 791 0.244883242067291 1147 9903 A bile acid which acts as a detergent.
SGTC_1104 tacrolimus 29.8 µM 0.689585892193363 0.240996825622059 no 792 0.245227320878726 1256 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3312 9133330 71.43 µM 0.688178296110897 0.241454018971445 no 793 0.24567025487924 1226 17617324
SGTC_1939 st074455 53.6 µM 0.68782661047794 0.241568321512715 no 794 0.245780988274149 1227 1644229
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.68704586070422 0.241822180630724 no 795 0.246026914567555 1220 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1529 apigenin 74 µM 0.68694792093891 0.241854035751263 no 796 0.246057773669717 1250 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2808 7946468 45.46 µM 0.685791708934816 0.24223026824601 no 797 0.246422232684514 1201 2970879
SGTC_2846 9008642 19.48 µM 0.685550919873192 0.242308661131654 no 798 0.246498170149851 1207 2992898
SGTC_1597 7-benzyloxygramine 47.5 µM 0.683407226113525 0.243007181982471 no 799 0.247174777581674 1202 260807
SGTC_408 cantharidin 100 µM 0.683246240141355 0.243059683063256 no 800 0.247225629151104 1183 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1602 st001878 87.6 µM 0.680667592254415 0.243901472578109 no 801 0.248040923462656 1243 595405 YLR310C CDC25
SGTC_444 curcumin 90.4 µM 0.680577261407067 0.243930989221738 no 802 0.248069509461138 1184 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1889 st059080 5.18 µM 0.679164918039384 0.24439273921101 no 803 0.248516686528269 1229 176925 Isolated from Daphnopsis sellowiana.
SGTC_1320 1313-0481 95.3 µM 0.678190445656539 0.244711606544116 no 804 0.248825474827475 1247 6813365 YLR208W SEC13
SGTC_2214 7179297 48.276 µM 0.67814729742998 0.244725730704999 no 805 0.248839152247159 1236 769744
SGTC_2135 5326629 150.42 µM 0.67759824096161 0.244905497429743 no 806 0.249013230862136 1194 5020077
SGTC_291 SEC14.278 35.5 µM 0.676914167646883 0.245129569438948 no 807 0.249230207257448 1223 1068044
SGTC_2703 st077852 53.4 µM 0.675405575232492 0.245624106683984 no 808 0.249709062166952 1214 6281836
SGTC_2409 alverine citrate 63.97 µM 0.675135326206403 0.245712754573579 no 809 0.249794895740248 1303 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_279 1273-0055 2.93 µM 0.674304760797588 0.245985306605516 no 810 0.250058788964276 1273 2847562
SGTC_3247 9135149 49.47 µM 0.673677356067344 0.246191298470787 no 811 0.250258230535943 1200 8934436 YOR116C RPO31
SGTC_1394 3474-0001 65.7 µM 0.673023695590075 0.246406009072426 no 812 0.250466108056023 1172 5017666 YIL048W NEO1
SGTC_2854 9024559 71.43 µM 0.672751848787397 0.246495333271133 no 813 0.250552587882802 1212 3163529
SGTC_1700 st030840 7.9285 µM 0.672479717229839 0.246584768409319 no 814 0.250639174137928 1246 5499307
SGTC_1756 st041558 35.5 µM 0.672060460867141 0.246722589640633 no 815 0.250772603271661 1300 3955792
SGTC_2177 5811945 192 µM 0.668864011083964 0.247774706277735 no 816 0.251791114701319 1269 5343475
SGTC_570 0987-0065 62.6 µM 0.668836000996171 0.24778393641938 no 817 0.251800049432169 1129 3104428
SGTC_2444 5485484 36.41 µM 0.666911131650419 0.248418676611797 no 818 0.252414450059613 1291 6790631
SGTC_358 0075-0058 9.45 µM 0.666358098742011 0.248601203514706 no 819 0.252591119092811 1257 1069125
SGTC_3066 9117245 49.47 µM 0.665476813714969 0.248892216642746 no 820 0.252872784402179 1290 17176980
SGTC_370 0180-0345 38.7 µM 0.66534569762919 0.248935528570437 no 821 0.252914704210965 1193 3989527
SGTC_3276 9139060 49.47 µM 0.665062079392508 0.249029230663149 no 822 0.253005393789951 1294 4870619
SGTC_648 0375-0473 33.3 µM 0.662903822373572 0.249742892230089 no 823 0.253696076758813 1254 1713139
SGTC_1439 4092-1168 46 µM 0.662099559632135 0.250009111819488 no 824 0.253953709017705 1246 2886240
SGTC_390 dec-rvkr-cmk 16.7 µM 0.661286750602445 0.250278313234419 no 825 0.25421421835953 1292 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3211 9128781 49.47 µM 0.660671491975664 0.25048218833821 no 826 0.254411504954684 1240 17194361
SGTC_3145 9085516 49.47 µM 0.657124879934962 0.251659124763971 no 827 0.25555031119208 1263 25236195
SGTC_467 ro 31-8220 72.8 µM 0.655931714649784 0.252055729982308 no 828 0.255934030642922 1218 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2126 5251174 33.877 µM 0.655788054448116 0.252103504513755 no 829 0.255980251732238 1295 790722
SGTC_1648 st011736 69.8 µM 0.655071058791683 0.252342014467281 no 830 0.256211002288798 1289 2855514
SGTC_477 mead ethanolamide 10 µM 0.654894567636266 0.252400742820891 no 831 0.256267819028048 1143 16061185
SGTC_3343 9148379 18.9835 µM 0.653909910228143 0.252728524882473 no 832 0.256584924383486 1291 1955036
SGTC_707 0865-0008 204 µM 0.653114498206305 0.252993472732916 no 833 0.256841233088775 1283 723043
SGTC_876 0720-0963 56.8 µM 0.652775585673766 0.253106407225926 no 834 0.256950482659877 1283 765861
SGTC_566 0958-0068 16.5 µM 0.652695627400389 0.253133055273219 no 835 0.256976260997093 1248 6815365
SGTC_997 3996-0078 137 µM 0.652204504037564 0.253296766491378 no 836 0.257134627385307 1295 735687
SGTC_1181 1222-0449 220 µM 0.651937843503695 0.253385678509916 no 837 0.257220635315024 1317 658318
SGTC_2180 6301957 200 µM 0.651659049304965 0.253478653766572 no 838 0.257310572791963 1230 845462
SGTC_1387 3342-1166 1.8 µM 0.650007420816485 0.254029823877811 no 839 0.257843714093034 1261 3418228
SGTC_2155 5570423 76 µM 0.649876663970598 0.2540734859984 no 840 0.257885946530974 1239 797402
SGTC_2968 9090663 33.37 µM 0.648606394591277 0.254497857158267 no 841 0.258296410607228 1241 25236811
SGTC_2618 avocadyne 43.43 µM 0.647401410245419 0.254900760891464 no 842 0.25868609172494 1235 3015189
SGTC_2823 7987624 58.44 µM 0.645725406903206 0.255461711107129 no 843 0.259228601743822 1305 2239440
SGTC_1231 0242-0792 125 µM 0.645418252053977 0.255564584241978 no 844 0.259328089241651 1262 3707635
SGTC_174 3553-0389 74.3 µM 0.643317967976297 0.256268596524668 no 845 0.260008899822112 1272 738071
SGTC_941 3237-0776 460 µM 0.640781082877809 0.257120302978408 no 846 0.260832462600962 1302 760008
SGTC_2073 5212005 126 µM 0.640329659565799 0.257272013097657 no 847 0.260979151113582 1184 691789
SGTC_524 r073-0010 27.8 µM 0.638780997177364 0.257792826445766 no 848 0.26148270602259 1235 2772106
SGTC_1779 st039427 55 µM 0.637011317581912 0.258388636839467 no 849 0.262058735839755 1350 1124498
SGTC_2896 9052656 71.43 µM 0.636374776746522 0.258603119823907 no 850 0.262266088498828 1268 6469436
SGTC_1413 3910-0535 34.4 µM 0.635734550636483 0.258818937515933 no 851 0.26247472637513 1317 2876951
SGTC_2971 9092186 9.93 µM 0.635057380771818 0.259047310183238 no 852 0.262695495967268 1229 25236400
SGTC_2321 7390090 138.78 µM 0.633605026653709 0.259537461630378 no 853 0.263169309770774 1234 649046
SGTC_2822 7994718 71.43 µM 0.632891204687759 0.259778543078019 no 854 0.263402345887723 1285 1018011
SGTC_2586 curcumin 80 µM 0.632718554686813 0.259836870082203 no 855 0.263458725459338 1315 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_410 α-linolenic acid 100 µM 0.632520152473511 0.259903905396356 no 856 0.263523522128038 1316 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2299 7976368 114.88 µM 0.631086826496234 0.26038845649786 no 857 0.263991877088788 1306 2979718
SGTC_1953 st076800 12.1 µM 0.630238382406555 0.260675501140347 no 858 0.264269315225558 1255 297591
SGTC_1416 3966-0321 25.3 µM 0.629663910992286 0.260869948080126 no 859 0.264457249551811 1296 582530 YLR208W SEC13
SGTC_2905 7799065 20.05 µM 0.629119177102288 0.261054398359233 no 860 0.264635518258768 1257 1296806
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.628778504890878 0.261169786153209 no 861 0.264747037138297 1344 364106
SGTC_789 1309-1135 70.6 µM 0.628582378739192 0.261236227185334 no 862 0.26481124977342 1295 3092424
SGTC_732 3970-1727 52.7 µM 0.627802715260365 0.261500437158728 no 863 0.265066593581131 1319 1275699
SGTC_1431 4049-0260 9.09 µM 0.627798194523786 0.261501969532057 no 864 0.265068074510291 1294 3854841
SGTC_134 0269-0018 6.916 µM 0.626046004108442 0.262096248458866 no 865 0.265642383568292 1248 4378915
SGTC_1848 st056003 16.4 µM 0.625783301748537 0.262185407124011 no 866 0.265728542925174 1341 146492
SGTC_384 k007-0144 5.16 µM 0.625070634929607 0.262427357655093 no 867 0.265962349933453 1317 6824886
SGTC_2725 haloperidol 53.21 µM 0.624603264394229 0.262586092093661 no 868 0.266115738328597 1260 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_224 benfluorex 43.875 µM 0.624333668334601 0.262677678143073 no 869 0.266204238615647 1311 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2521 angolensin 13.4 µM 0.623018020164479 0.263124859021681 no 870 0.266636340053958 1329 821428 A flavenoid.
SGTC_79 0052-0007 94.094 µM 0.62206688235625 0.263448387104098 no 871 0.266948945191493 1358 2801472
SGTC_2922 7999257 32.47 µM 0.621782604411081 0.263545123215568 no 872 0.267042413152192 1305 2988377
SGTC_1271 0832-2808 169 µM 0.620194629606962 0.264085823750114 no 873 0.26756482838994 1324 3663794
SGTC_1992 st073643 23.3 µM 0.619749446370121 0.26423750864257 no 874 0.267711378110939 1302 3161292
SGTC_1548 st061468 90.8 µM 0.619620626700404 0.264281408951854 no 875 0.267753791759537 1301 390799
SGTC_1501 4491-0275 38.4 µM 0.619442041103592 0.264342275077448 no 876 0.267812596351671 1291 5104718
SGTC_1962 st076595 64.5 µM 0.618179096608895 0.264772919531869 no 877 0.268228643811514 1333 279619
SGTC_3074 9116018 49.47 µM 0.616921354993057 0.26520214410518 no 878 0.26864330024601 1363 17027303
SGTC_2878 9043973 25.97 µM 0.616252937382112 0.265430396069137 no 879 0.268863797390605 1378 6465167
SGTC_1420 4'-methoxyflavone 42 µM 0.615689662516185 0.265622821143049 no 880 0.269049680654456 1327 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2645 abamectin 100 µM 0.614190037357593 0.266135465396203 no 881 0.269544877999808 1285 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3328 9140624 29.0385 µM 0.613599658378516 0.266337422772341 no 882 0.269739954674286 1333 4904392
SGTC_420 mitomycin C 81.9 mM 0.613326009860026 0.266431059003269 no 883 0.269830399286546 1314 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2352 9027995 87.8 µM 0.611750681783927 0.266970423746646 no 884 0.270351362077918 1321 2997347
SGTC_548 1436-0017 110 µM 0.611409279228099 0.267087386670074 no 885 0.270464330544631 1389 9677137
SGTC_2892 9047358 58.44 µM 0.610417950326624 0.267427157896958 no 886 0.270792490148274 1290 6466771
SGTC_2076 5212012 200 µM 0.609610289844916 0.267704139095678 no 887 0.271059996847722 1242 604802
SGTC_962 1254-0300 21.5 µM 0.609262286108184 0.26782352895843 no 888 0.271175300417378 1336 7340576
SGTC_2658 polymyxin b sulfate 77.05 µM 0.608974177059306 0.267922391004126 no 889 0.271270777667931 1300 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_111 0083-0039 52.457 µM 0.607717857573209 0.268353700497322 no 890 0.271687308576695 1249 759313
SGTC_1213 1315-0166 115 µM 0.607553968515694 0.268409991307847 no 891 0.271741669223351 1290 768401
SGTC_2991 9074669 71.4286 µM 0.607511230159696 0.268424671584237 no 892 0.271755846072905 1374 17333109
SGTC_505 gw-5074 63.9 µM 0.606903461925272 0.268633478695746 no 893 0.271957490259646 1378 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1998 st075797 76.8 µM 0.60654739784603 0.268755847299655 no 894 0.272075659082289 1324 24208315
SGTC_2300 7976697 71.57 µM 0.60609838441748 0.268910199731358 no 895 0.272224711871366 1274 2236109
SGTC_2301 7769476 200 µM 0.604879025264453 0.269329589915078 no 896 0.272629690321856 1371 977820
SGTC_2371 9071574 200 µM 0.603698406946791 0.26973596773712 no 897 0.273022086733087 1313 45596039
SGTC_1512 0259-0544 12.2 µM 0.603643333493543 0.269754931933317 no 898 0.273040398063468 1318 18476
SGTC_1370 2001-0092 44.6 µM 0.602170229358016 0.27026243370432 no 899 0.273530415132805 1471 790957
SGTC_1970 st070122 35.8 µM 0.600746972086662 0.270753215666455 no 900 0.274004264066461 1376 102928
SGTC_171 k064-0041 9.68 µM 0.599884068204129 0.271050987415682 no 901 0.274291750420239 1293 53325
SGTC_1352 1496-0991 99 µM 0.59947798789136 0.271191174523849 no 902 0.274427092263398 1335 3000039
SGTC_569 4130-2812 160 µM 0.599073869171508 0.271330720328571 no 903 0.274561813043226 1289 743552
SGTC_935 2996-0153 430 µM 0.598225281946673 0.271623861495751 no 904 0.274844812129419 1351 23738523
SGTC_2580 diallyl disulphide 81.36 µM 0.597299988161623 0.27194368025757 no 905 0.275153556190528 1367 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_387 norethindrone acetate 66.7 µM 0.595989023732839 0.272397122759522 no 906 0.275591279692913 1344 541197
SGTC_1109 tnp00067 928.257 nM 0.595700213932231 0.272497068099412 no 907 0.275687757634896 1319 676295
SGTC_71 0417-1750 47.813 µM 0.595389706295345 0.272604542487416 no 908 0.275791502333598 1402 6811472
SGTC_844 0330-0132 15.3 µM 0.594173959103474 0.273025545081037 no 909 0.276197884028116 1351 2828079
SGTC_1144 3486-0183 12.5 µM 0.593967998460767 0.273096899359746 no 910 0.276266758554945 1347 6744069
SGTC_449 xestospongin c 11.1929 µM 0.593711653354472 0.27318572205201 no 911 0.276352493731566 1344 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_805 3852-0218 479 µM 0.592458977896667 0.273619975532076 no 912 0.276771641378776 1304 6615355
SGTC_2404 5161160 200 µM 0.592179912300483 0.273716763135655 no 913 0.276865059670425 1332 2831543
SGTC_662 k832-1615 104 µM 0.591929414199469 0.273803657169401 no 914 0.276948928031761 1368 5878478
SGTC_957 1187-1561 14.1 µM 0.59161279610668 0.273913506750572 no 915 0.277054951581481 1325 1538454
SGTC_2764 methyldopa 94.69 µM 0.590724513696304 0.274221809596209 no 916 0.277352510121343 1415 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_641 4092-0595 30 µM 0.589377063942635 0.274689806010058 no 917 0.277804179506904 1370 786260
SGTC_608 k048-0125 159 µM 0.588797964073108 0.274891059989754 no 918 0.27799840588128 1389 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3323 9138564 53.9225 µM 0.587217244977418 0.275440775278217 no 919 0.27852890594254 1397 43912313 YNL103W MET4
SGTC_1775 st081588 35.1725 µM 0.586187242191659 0.275799262698735 no 920 0.278874847019355 1356 1426443 YGL099W LSG1
SGTC_1180 1193-0155 285 µM 0.585190617715963 0.276146351071295 no 921 0.279209776405847 1345 2921347
SGTC_2697 mebhydrolin 72.4 µM 0.58499866819003 0.276213224786691 no 922 0.279274306135785 1418 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2377 9073351 62.6 µM 0.583731998235038 0.276654721866773 no 923 0.279700317769263 1335 7337946 YHR072W ERG7
SGTC_45 0kpi-0036 14.9 µM 0.583165040074825 0.276852446783059 no 924 0.279891101575073 1378 2795021
SGTC_246 cycloheximide 667 µM 0.582677847226084 0.277022409062021 no 925 0.280055094419207 1293 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3243 9134147 49.47 µM 0.582330571630523 0.277143590925905 no 926 0.280172018468739 1409 24282180
SGTC_1409 3909-8004 61.9 µM 0.580800364257037 0.277677865722477 no 927 0.280687504780049 1360 2119279
SGTC_2205 7238770 200 µM 0.579760416367878 0.278041252404073 no 928 0.2810380973064 1390 279867
SGTC_1760 st045453 10.4495 µM 0.579689305414723 0.27806610901896 no 929 0.28106207831928 1387 3323419 YIL048W NEO1
SGTC_3158 9100007 49.47 µM 0.579481203237471 0.278138856722431 no 930 0.281132263074683 1351 19297233
SGTC_2864 9034755 47.6 µM 0.576538628610346 0.279168505129646 no 931 0.28212558389695 1364 4930451
SGTC_2529 gangaleoidin 93.61 µM 0.57544730344464 0.279550845688524 no 932 0.282494410074805 1414 4565183
SGTC_1476 4112-3294 3.34 µM 0.574996743765627 0.279708771234209 no 933 0.282646749610029 1441 704369
SGTC_2945 9067681 61.76 µM 0.574128494145658 0.280013223206394 no 934 0.282940426338141 1432 16456930
SGTC_2585 alliin 100 µM 0.573834012105872 0.280116519887305 no 935 0.283040065197299 1488 87310 A garlic compound which reacts with lipids.
SGTC_69 0096-0274 206.684 µM 0.573617421154021 0.280192506173913 no 936 0.283113360126418 1460 6741392
SGTC_611 3453-1652 23.7 µM 0.572673044523894 0.280523937096924 no 937 0.283433045969131 1404 1560575
SGTC_1005 4092-0690 4.4 µM 0.572270315374477 0.280665333407697 no 938 0.283569428518529 1355 1529343
SGTC_1081 sertraline 6 µM 0.572007272637082 0.280757705085484 no 939 0.283658523818553 1398 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2168 5727979 200 µM 0.571852709534729 0.280811989255537 no 940 0.283710882195949 1306 695210
SGTC_550 4123-0385 25.7 µM 0.571473444247312 0.28094521267193 no 941 0.283839378231619 1361 5731123
SGTC_3238 9133470 49.47 µM 0.571097447015239 0.281077318274019 no 942 0.283966794536212 1451 3534688
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.56939346709761 0.281676382847561 no 943 0.284544574647735 1385 616764
SGTC_2353 9059630 146.67 µM 0.568887580381964 0.2818543547963 no 944 0.284716217135448 1424 4779114
SGTC_2813 7971799 71.43 µM 0.56878623880139 0.281890013478569 no 945 0.284750607297902 1428 2234054
SGTC_133 0724-0033 378.92 µM 0.568766510799664 0.281896955349367 no 946 0.284757302205775 1277 280309
SGTC_1880 MG-132 525 µM 0.568342525526 0.282046166794089 no 947 0.284901204285214 1375 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3311 9131146 2.8755 µM 0.567226784460776 0.28243900672928 no 948 0.285280056358157 1378 4900406 YPR165W RHO1
SGTC_2332 7982454 138.89 µM 0.567107419967639 0.282481049207736 no 949 0.285320601014191 1395 2981748
SGTC_1887 st057648 70.8 µM 0.566973614683906 0.282528181588641 no 950 0.285366054050726 1439 688672
SGTC_2833 9001315 45.46 µM 0.566340325915702 0.282751306328961 no 951 0.285581226092507 1430 2989378
SGTC_2106 5357045 167.29 µM 0.565618735153816 0.283005645390229 no 952 0.285826494512826 1456 668842
SGTC_1745 st081495 74 µM 0.564743145040163 0.283314412000361 no 953 0.286124241703253 1360 13842402 YBL026W LSM2
SGTC_534 k292-0788 63.4 µM 0.563397401807348 0.283789287319226 no 954 0.286582153007968 1451 4146317
SGTC_1624 st003710 6.25 µM 0.563185346809355 0.283864150366861 no 955 0.286654339904782 1467 24207033
SGTC_1929 genistein trimethyl ether 50.5 µM 0.561427837343544 0.28448497804014 no 956 0.28725295573272 1439 136420
SGTC_299 1273-0059 1.44 µM 0.560332739735407 0.284872141143876 no 957 0.287626249937551 1386 2848077
SGTC_1646 st011709 75.6 µM 0.559818748712197 0.285053945244272 no 958 0.287801536974317 1390 5757843
SGTC_619 1652-1634 108 µM 0.55918683962859 0.285277534000628 no 959 0.288017106890888 1373 5400454
SGTC_2383 9036125 200 µM 0.55692148041039 0.286079773283442 no 960 0.288790538862514 1391 79580
SGTC_779 1360-0071 233 µM 0.556284825313164 0.28630542689763 no 961 0.289008079567105 1551 7566
SGTC_2097 5376186 200 µM 0.556089070051874 0.286374826631117 no 962 0.289074983296903 1432 742755
SGTC_1881 5652484 16 µM 0.554642090835143 0.286888061468301 no 963 0.289569746517558 1427 2255129
SGTC_2686 alizarin 95.37 µM 0.553738699549551 0.287208709770426 no 964 0.289878843078522 1369 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1864 st057645 30.4 µM 0.552921466630447 0.287498923209886 no 965 0.290158593681329 1420 688666
SGTC_70 0141-0289 43.283 µM 0.552743997964622 0.287561963700761 no 966 0.290219360476863 1511 352408
SGTC_225 nsc-122657 1.016 µM 0.55222097964846 0.287747788476284 no 967 0.290398481107574 1399 275685
SGTC_689 0833-0039 98 µM 0.551816374444149 0.287891580804713 no 968 0.29053708372061 1422 5374726
SGTC_2182 6325192 200 µM 0.551488805970053 0.288008019959976 no 969 0.290649319102274 1360 736248
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.550744751573061 0.288272587882798 no 970 0.290904331138571 1453 676296 Flavone; oxidizing agent.
SGTC_1212 0520-0165 585 µM 0.549581432773661 0.288686465727616 no 971 0.291303248366503 1616 5403258
SGTC_1790 st045711 43.5 µM 0.548694469311445 0.289002211604082 no 972 0.291607571168946 1526 585119
SGTC_2682 pyrogallin 40.03 µM 0.548266002427093 0.28915479765301 no 973 0.291754633957588 1428 822798 An ATP competetive kinase inhibitor.
SGTC_3070 9117005 49.47 µM 0.547802635034472 0.289319855126069 no 974 0.291913714542519 1468 8779016
SGTC_2564 betulinic acid 100 µM 0.54777797235597 0.289328641532787 no 975 0.291922182721316 1569 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_29 0299-0004 12.984 µM 0.545900793386853 0.289997779152028 no 976 0.292567066484913 1330 16871 A napthoquinone isolated from Swertia calycina.
SGTC_292 k038-0015 474 µM 0.543517189364321 0.290848480635948 no 977 0.293386879492003 1430 46368540
SGTC_2913 7966556 36.57 µM 0.542570634277233 0.291186626751435 no 978 0.293712731157882 1457 2976516
SGTC_1128 3448-9350 235 µM 0.539491383748878 0.29228792208616 no 979 0.294773920333859 1415 619386
SGTC_108 0509-0257 621.132 µM 0.539417979985536 0.292314198600491 no 980 0.294799238723519 1391 536624
SGTC_3089 9117425 49.47 µM 0.538760980249598 0.292549435217756 no 981 0.295025895377931 1358 9401657
SGTC_1148 3909-7663 27.7 µM 0.536285238303516 0.293436655890659 no 982 0.295880715569847 1479 4084526
SGTC_2031 5180455 200 µM 0.535548455014246 0.293700934122916 no 983 0.296135330371658 1387 29949
SGTC_3046 9092212 49.47 µM 0.534764112658802 0.293982392402617 no 984 0.296406490880021 1461 25236637
SGTC_3331 9141060 1.957 µM 0.533279854611091 0.294515353784651 no 985 0.2969199353878 1385 4906567 YPR165W RHO1
SGTC_2278 7948257 134.34 µM 0.533225385404367 0.294534920846503 no 986 0.296938785480207 1436 1247028
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.532930934811322 0.294640707197939 no 987 0.29704069511888 1442 442882
SGTC_705 1124-0212 310 µM 0.530510340329589 0.295511010154945 no 988 0.297879070807727 1511 9554485
SGTC_122 0236-0016 402.397 µM 0.529836258437447 0.295753580505455 no 989 0.298112731772145 1463 6808838
SGTC_591 4299-0174 154 µM 0.529102830188059 0.296017610690037 no 990 0.298367059124177 1448 5509088
SGTC_1102 cgs 12066b 26.1 µM 0.528232569613826 0.296331040051455 no 991 0.298668963204777 1446 6438352 A 5-HT1B full agonist.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.528166567409823 0.296354817332276 no 992 0.298691865845287 1461 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2876 9059903 25.97 µM 0.527732387565338 0.296511252332955 no 993 0.298842545331378 1425 6916095
SGTC_656 4090-1979 187 µM 0.527422622515163 0.296622883805019 no 994 0.298950068522908 1517 22330961
SGTC_1283 0922-0125 16.4 µM 0.527128758253639 0.296728802825682 no 995 0.299052088597392 1524 3360884
SGTC_1266 0828-0227 32.9 µM 0.526657010755306 0.296898873428247 no 996 0.299215896970094 1476 3913820
SGTC_2963 9082507 9 µM 0.525744951908748 0.29722780794005 no 997 0.299532713304135 1492 16459611
SGTC_2894 9048625 32.47 µM 0.525577716453284 0.297288139562215 no 998 0.299590821358244 1557 4092861
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.525507005585563 0.297313650796177 no 999 0.299615392271543 1520 688761
SGTC_2349 9023730 187.07 µM 0.524022139753965 0.29784959507519 no 1000 0.300131570531019 1535 4126287
SGTC_2435 5706476 10.6 µM 0.523740203854584 0.297951406158707 no 1001 0.300229624248028 1491 5725375
SGTC_1100 amiodarone 5.07 µM 0.523399438273564 0.298074482651657 no 1002 0.300348157506062 1482 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1085 doxorubicin 7.67 µM 0.522685612794573 0.29833237464131 no 1003 0.300596525927694 1532 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_201 4262-0159 12.803 µM 0.522045586644179 0.298563690619734 no 1004 0.300819295422215 1484 1341029
SGTC_2715 st079500 56.4 µM 0.521762027728291 0.298666199547108 no 1005 0.300918015622615 1404 28246688
SGTC_1728 st035614 33.7865 µM 0.521427249177236 0.298787245397338 no 1006 0.301034586590225 1495 15945546
SGTC_2511 berberine 10.47 µM 0.518557059118047 0.299825933432273 no 1007 0.302034830166348 1450 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_923 1900-2434 73.3 µM 0.518369607617932 0.299893826763088 no 1008 0.302100207753629 1411 5910570
SGTC_873 0591-4978 488 µM 0.51695630096087 0.300405938217542 no 1009 0.30259333207894 1607 3305145
SGTC_1142 3253-1408 9.78 µM 0.516795840242688 0.300464106101648 no 1010 0.302649342076122 1455 256655
SGTC_1414 3917-0015 5.4 µM 0.516179201844776 0.300687688205389 no 1011 0.302864627470287 1447 6618702
SGTC_402 epigallocatechin gallate 10 µM 0.515782957232366 0.300831399063114 no 1012 0.303003003516739 1436 65064 An antioxidant.
SGTC_1626 st003712 1.76 µM 0.515498560928766 0.300934563628097 no 1013 0.303102337472986 1487 24207035
SGTC_2468 5987765 72.9 µM 0.51399773290752 0.301479251993286 no 1014 0.303626787853199 1514 26772094
SGTC_1024 4507-0395 26 µM 0.513120569308489 0.301797802082057 no 1015 0.303933491959982 1496 4201836
SGTC_282 k297-0036 65.7 µM 0.512287490769172 0.30210048227131 no 1016 0.304224909375477 1483 5061378
SGTC_1839 st053978 48 µM 0.511951039915452 0.302222762682587 no 1017 0.304342637799357 1480 3788398
SGTC_1738 st035555 74 µM 0.511110688596608 0.302528278726559 no 1018 0.304636775954862 1472 5331140
SGTC_1813 st051246 8.6015 µM 0.510661354599614 0.302691694265137 no 1019 0.304794102834502 1490 5291959
SGTC_2460 5552655 174.22 µM 0.510521027595017 0.302742737039159 no 1020 0.304843243417453 1425 5401989
SGTC_3209 9113616 49.47 µM 0.509990766603739 0.302935649838122 no 1021 0.305028965288857 1595 16649353
SGTC_2359 9039622 200 µM 0.507345721894915 0.303898756908947 no 1022 0.305956131460237 1485 6463596
SGTC_354 2783-3500 4.88 µM 0.507246966705513 0.303934741833151 no 1023 0.305990772206586 1402 6740761
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.506801071375572 0.304097243120531 no 1024 0.306147202268434 1479 6857784
SGTC_2680 butyl paraben 22.24 µM 0.506492989873092 0.30420954239887 no 1025 0.306255304808684 1494 7184 An antifungal and steroid mimetic.
SGTC_572 0960-0087 17.7 µM 0.504968885881731 0.304765367501002 no 1026 0.306790344789029 1415 6796365
SGTC_1821 st053465 65.6 µM 0.504729630728102 0.304852662384585 no 1027 0.306874373257272 1430 675086
SGTC_435 c-PAF 6.7 µM 0.504614573849072 0.304894646113021 no 1028 0.306914785836653 1461 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_544 k015-0020 52.4 µM 0.502977012812073 0.305492462883301 no 1029 0.307490216951059 1482 3008304
SGTC_352 k048-0007 5.11 µM 0.501559342671708 0.306010424352308 no 1030 0.307988762421551 1445 6811911
SGTC_1873 rapamycin 2 nM 0.500580476716789 0.306368290460517 no 1031 0.308333202667003 1473 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1575 cyproterone acetate 48 µM 0.499767288124941 0.306665726694735 no 1032 0.308619473274275 1416 9880 An androgen receptor antagonist and liver toxin.
SGTC_1552 6-methylflavone 10.6 µM 0.499483016299926 0.306769733541342 no 1033 0.308719574279517 1493 689013
SGTC_2765 myclobutanil 7.74 µM 0.499007397088063 0.306943783657241 no 1034 0.308887086470485 1478 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_651 3253-0966 34.4 µM 0.498850368533398 0.307001256912105 no 1035 0.308942400364038 1455 781462
SGTC_1156 4092-0367 4.88 µM 0.498212728423104 0.307234685177195 no 1036 0.30916705598033 1492 1357585
SGTC_3275 9138069 49.47 µM 0.497747679421663 0.307404980299996 no 1037 0.309330948705298 1510 17617007
SGTC_1999 st074831 12.5 µM 0.497085497176868 0.30764753480681 no 1038 0.309564380663292 1449 17112523
SGTC_755 1995-0008 37.3 µM 0.497058330297316 0.307657487714666 no 1039 0.309573959151677 1486 689533
SGTC_3065 9113888 49.47 µM 0.494799487387662 0.308485536221353 no 1040 0.310370833124587 1534 16648368
SGTC_132 0417-1715 25.805 µM 0.49475809297074 0.308500719731558 no 1041 0.3103854445598 1607 6769098
SGTC_3316 9136639 10.545 µM 0.493685846475485 0.308894134785452 no 1042 0.310764031221556 1551 4903665
SGTC_640 3381-0960 37.1 µM 0.491238881486254 0.30979276505305 no 1043 0.311628750952152 1576 1745025
SGTC_2767 sibutramine 71.45 µM 0.490104165608598 0.310209867806049 no 1044 0.312030095277102 1602 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2480 5767542 37.17 µM 0.48974413607994 0.310342259768711 no 1045 0.312157482911608 1557 2867358
SGTC_2022 5136654 200 µM 0.489563949060206 0.310408528322706 no 1046 0.312221246112479 1509 1713771
SGTC_1925 st057770 10.1 µM 0.48822390510774 0.310901557993186 no 1047 0.3126956269561 1410 5989122
SGTC_2726 cimetidine 79.27 µM 0.488142014436294 0.310931698272775 no 1048 0.312724626649227 1511 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_737 1950-0117 57.9 µM 0.487577062249824 0.311139666359267 no 1049 0.312924723017914 1534 5393513
SGTC_883 0850-0245 24.6 µM 0.486802037961433 0.311425063516345 no 1050 0.313199312993612 1575 6823229 YPR165W RHO1
SGTC_272 doxorubicin 8.13 µM 0.486658609142993 0.311477892589627 no 1051 0.313250140980994 1490 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2051 5263410 176 µM 0.484630848791979 0.312225191619323 no 1052 0.313969113490113 1519 227584
SGTC_2497 7-hydroxyflavone 100 µM 0.484284972332442 0.31235273619647 no 1053 0.314091819752347 1541 5281894
SGTC_774 k060-0086 136 µM 0.484072402623036 0.312431134052593 no 1054 0.314167243104966 1568 5911235
SGTC_761 k216-0224 480 µM 0.481473184519964 0.313390437714475 no 1055 0.315090116829197 1674 1340404
SGTC_2413 inermin 26.06 µM 0.480882264952697 0.313608707284647 no 1056 0.315300089076519 1639 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_896 0964-0007 44.5 µM 0.480038798072276 0.313920374009089 no 1057 0.315599902667931 1507 6756758
SGTC_634 1611-4317 11.2 µM 0.479457978710137 0.314135067921217 no 1058 0.315806427776855 1552 2843522
SGTC_233 rapamycin 362 pM 0.478743053110536 0.3143994192015 no 1059 0.316060716742144 1536 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.478523799343976 0.314480509675927 no 1060 0.316138719664906 1482 688803
SGTC_284 0988-0104 32.6 µM 0.477707104561673 0.314782641007921 no 1061 0.31642934347855 1557 4666532
SGTC_1042 0350-0096 82 µM 0.475518126321953 0.315593051640103 no 1062 0.31720885827994 1477 3122515
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.475467108674322 0.315611950158742 no 1063 0.317227035814321 1545 368090
SGTC_2750 bromebric acid 70.15 µM 0.475402129931469 0.315636020998151 no 1064 0.31725018831074 1565 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2951 9072950 58.06 µM 0.475333326329702 0.315661509577561 no 1065 0.317274704417566 1505 16488155
SGTC_1949 st076024 69.1 µM 0.475280029659071 0.315681254152748 no 1066 0.317293695644119 1464 2921930
SGTC_2558 carylophyllene oxide 100 µM 0.475151103324721 0.315729019080978 no 1067 0.317339638011991 1568 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_365 0121-0052 13.6 µM 0.473248398092061 0.316434295277573 no 1068 0.318017986131823 1552 3101739
SGTC_1023 4482-3888 16 µM 0.471626211360057 0.317036119406387 no 1069 0.318596807105604 1620 3303168
SGTC_929 2805-0021 398 µM 0.470870226401585 0.317316752043348 no 1070 0.318866705477066 1570 3098024
SGTC_2146 5545642 200 µM 0.468819593683842 0.318078505433831 no 1071 0.319599296706054 1522 825326
SGTC_1731 st035964 63 µM 0.467555182401541 0.31854858339679 no 1072 0.320051360633833 1520 6739575
SGTC_256 clotrimazole 625 nM 0.467173852960294 0.318690409978126 no 1073 0.320187749530937 1536 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_686 1319-0111 510 µM 0.466398319306484 0.318978933541435 no 1074 0.320465207150725 1617 4562600
SGTC_3232 9132874 49.47 µM 0.464905142656532 0.319534752354102 no 1075 0.320999693791396 1498 3784940
SGTC_1655 st012546 55.1 µM 0.464585560454573 0.319653766106763 no 1076 0.321114137361778 1526 720985 YLR208W SEC13
SGTC_1818 st052136 56.3 µM 0.464463813476492 0.31969911007852 no 1077 0.321157739876024 1476 674169
SGTC_143 4032-1194 15.74 µM 0.464197053322193 0.319798472806894 no 1078 0.321253286089861 1538 1806963
SGTC_1758 st042942 75.2445 µM 0.462825855094224 0.320309420202423 no 1079 0.321744598513786 1517 669317
SGTC_3041 9091929 49.47 µM 0.462605805885912 0.320391448549884 no 1080 0.321823473148591 1570 25236887
SGTC_3225 9130819 49.47 µM 0.461639992592625 0.320751581165766 no 1081 0.322169755049758 1570 4547121
SGTC_2341 7987486 176.74 µM 0.461439571808889 0.320826335254613 no 1082 0.322241633108548 1669 1258686
SGTC_2689 tacrolimus 100 µM 0.461315714967304 0.32087253571931 no 1083 0.322286055923898 1540 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2242 6630449 61.2675 µM 0.461110200099176 0.320949201975994 no 1084 0.322359772018229 1548 691249 YDR170C SEC7
SGTC_87 0100-0052 35.5 µM 0.459932632806933 0.32138863447213 no 1085 0.322782288056475 1598 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3206 9114350 49.47 µM 0.458041938384825 0.322094707459305 no 1086 0.323461155676044 1502 17087243
SGTC_1754 st042065 16.137 µM 0.457973909602993 0.322120124552846 no 1087 0.323485592879803 1482 1126236 YIL048W NEO1
SGTC_2513 baicalein 25.65 µM 0.457460525883985 0.322311963158831 no 1088 0.323670034407139 1459 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1690 st023502 41.2 µM 0.455820715527634 0.322925035978386 no 1089 0.324259453184151 1614 24207482
SGTC_196 k015-0023 18.111 µM 0.455650306000358 0.322988774313497 no 1090 0.324320731041631 1540 5211998
SGTC_1987 st072290 61.9 µM 0.455295379152538 0.323121544414726 no 1091 0.324448375076628 1563 54697379
SGTC_355 1311-2252 105 µM 0.453880148487239 0.323651174136314 no 1092 0.324957546219826 1519 5338538
SGTC_169 k015-0017 16.025 µM 0.451179577888493 0.324662814841899 no 1093 0.325930063602105 1643 1840002
SGTC_2496 diffractaic acid 79.83 µM 0.450923576422425 0.324758780956348 no 1094 0.326022315317082 1668 94870 An apoptosis inducer which activates caspases.
SGTC_1794 st048918 76.9 µM 0.450479807535681 0.324925162153963 no 1095 0.32618225541454 1603 672303
SGTC_2491 paeonol 100 µM 0.449576027937686 0.325264122029054 no 1096 0.326508088225312 1521 11092 Increases levels of cortical cytochrome oxidase.
SGTC_502 l-744,832 89.3 µM 0.448002727426768 0.325854528641455 no 1097 0.32707561410975 1642 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1333 1482-0047 286 µM 0.447048546361077 0.326212813590005 no 1098 0.32742000429994 1603 3811116
SGTC_2540 epiandrosterone 100 µM 0.44660606281031 0.326379015984435 no 1099 0.327579758667133 1576 441302 A steroid.
SGTC_616 4092-0450 108 µM 0.445994858259405 0.326608648812615 no 1100 0.327800480026234 1594 787165
SGTC_1689 st020265 53.493 µM 0.443606952380701 0.327506427047901 no 1101 0.328663389176018 1651 5758320 YPR016C TIF6
SGTC_1748 st037455 53.6035 µM 0.442196277025118 0.328037266540316 no 1102 0.329173589950795 1613 580690
SGTC_2630 antimycin a 100 µM 0.440134405842551 0.328813777148098 no 1103 0.329919882055951 1495 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1203 3992-3522 103 µM 0.439515943648509 0.329046837325342 no 1104 0.330143866012446 1786 5322312
SGTC_317 4495-0002 170 µM 0.439292680235267 0.32913098784054 no 1105 0.330224738662033 1544 15991618
SGTC_1015 4130-4525 82 µM 0.437235844447028 0.329906639462192 no 1106 0.33097015849834 1516 1363237
SGTC_949 1165-0505 146 µM 0.436274283932932 0.330269504019708 no 1107 0.331318868781346 1556 6244267
SGTC_3296 9122258 64.045 µM 0.434109124618894 0.331087155417168 no 1108 0.332104599881878 1584 4730474
SGTC_2495 cafestol 54.53 µM 0.433605961836373 0.331277285543057 no 1109 0.332287302357843 1606 16667697 An anti-infammatory.
SGTC_216 k038-0035 28.382 µM 0.433346223482726 0.331375449904647 no 1110 0.332381631058229 1599 4444231 YPR107C YTH1
SGTC_88 0180-0332 8.668 µM 0.431757508716174 0.331976133679915 no 1111 0.332958832582844 1618 3101745
SGTC_2388 9080168 200 µM 0.429989099508217 0.332645267048601 no 1112 0.333601785261862 1512 15943073
SGTC_917 harmaline 728.087 nM 0.429317890772308 0.332899379831325 no 1113 0.33384594936644 1638 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1139 k015-0024 46.9 µM 0.428506845118744 0.333206535862013 no 1114 0.334141075512942 1642 2766652
SGTC_2625 euphol 100 µM 0.428127592223617 0.333350203443124 no 1115 0.334279114601299 1718 6708538 A triterpene alcohol.
SGTC_2072 5231554 129 µM 0.42799739764512 0.333399529048693 no 1116 0.33432650751917 1709 789545
SGTC_68 0986-0284 82.829 µM 0.426797639592807 0.333854205691458 no 1117 0.334763362937868 1507 423278 YIL048W NEO1
SGTC_3337 9144342 33.5465 µM 0.426701227341146 0.333890753992935 no 1118 0.334798478247683 1654 17682949
SGTC_373 0844-0104 25.9 µM 0.42418036133577 0.334846931252078 no 1119 0.335717141006467 1703 5375804
SGTC_1264 0783-0040 158 µM 0.423425480666888 0.335133470114678 no 1120 0.335992428689693 1520 2855798
SGTC_1995 st072814 61.1 µM 0.421033626678796 0.336042007162451 no 1121 0.336865263610982 1550 5769371
SGTC_320 4092-0846 5.34 µM 0.420918988825322 0.33608557605248 no 1122 0.336907119353315 1637 1359356
SGTC_183 3914-0051 30.55 µM 0.420497474921595 0.336245794188512 no 1123 0.33706103681809 1740 1596232
SGTC_1151 3909-8316 15.3 µM 0.419875950089875 0.336482091074654 no 1124 0.337288038830233 1587 800431
SGTC_2653 dihydrofissinolide 100 µM 0.419102245880438 0.336776335129759 no 1125 0.337570704702509 1636 6857746
SGTC_3055 9094636 49.47 µM 0.41816157193228 0.337134213323459 no 1126 0.337914494935411 1653 25236176
SGTC_1855 st056195 39.6 µM 0.41772666630348 0.337299722473371 no 1127 0.338073486616269 1686 4028379
SGTC_48 0382-0018 55 µM 0.417633565317579 0.337335157391058 no 1128 0.338107525989842 1724 762596
SGTC_598 3937-0236 20.2 µM 0.416871887534554 0.337625111701854 no 1129 0.338386058597958 1651 1379313
SGTC_948 3448-0295 75.3 µM 0.416530848138361 0.337754969307811 no 1130 0.338510799580749 1578 678569
SGTC_2308 7584454 197.62 µM 0.415692514141559 0.338074263906207 no 1131 0.338817509852657 1692 893577
SGTC_2926 9010726 65.15 µM 0.414365805162791 0.338579802947723 no 1132 0.339303113867278 1563 2994293
SGTC_1743 st037606 46.3785 µM 0.413303306896199 0.338984875081151 no 1133 0.339692203671939 1608 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2976 9009005 19.48 µM 0.411019061363425 0.339856362316549 no 1134 0.340529278889136 1758 2993148
SGTC_2614 arthonioic acid 13.39 µM 0.40996081592365 0.340260395631947 no 1135 0.340917345888431 1529 6710684
SGTC_1650 st011916 45.8 µM 0.408332451778513 0.340882455908973 no 1136 0.341514808728033 1703 242528
SGTC_2105 5350118 200 µM 0.407991487722106 0.341012764315224 no 1137 0.341639962158867 1583 2133313
SGTC_2273 7815444 169.05 µM 0.407716695688754 0.341117797141576 no 1138 0.341740839320312 1747 2824616
SGTC_2925 9010536 32.5 µM 0.407711523770639 0.341119774104358 no 1139 0.341742738058773 1684 2994177
SGTC_3148 9097893 49.47 µM 0.405308632741286 0.342038748794761 no 1140 0.342625330851695 1474 17174100
SGTC_1390 3413-2614 145 µM 0.405107968245214 0.342115534457078 no 1141 0.342699074799019 1634 3421432
SGTC_2066 5222451 176 µM 0.404511484275361 0.342343821729161 no 1142 0.342918317286198 1565 2281147
SGTC_586 0957-0265 8.15 µM 0.403806901143018 0.342613555105138 no 1143 0.343177360643202 1645 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.403429313712658 0.342758138775457 no 1144 0.343316212810004 1679 17037758
SGTC_1798 st045719 60.953 µM 0.40245621789007 0.343130857329954 no 1145 0.34367415180127 1650 3980186
SGTC_1554 st069299 38.7 µM 0.402304284460412 0.343189065189903 no 1146 0.343730050941238 1652 24207999
SGTC_1123 mangostin 811.285 nM 0.401383636255061 0.343541858161577 no 1147 0.344068847615305 1594 5281650 An antioxidant.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.400652119767885 0.343822272960349 no 1148 0.344338133487683 1691 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3167 9103034 49.47 µM 0.398988822629362 0.344460190181276 no 1149 0.344950720078255 1637 5127859
SGTC_1603 st002045 67.8 µM 0.397090279141496 0.345188871402189 no 1150 0.345650444017124 1717 5887985
SGTC_2518 prenyletin 46.28 µM 0.396300321272912 0.345492235011896 no 1151 0.345941745127983 1705 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2445 5742597 35.57 µM 0.39624321185931 0.345514170307223 no 1152 0.345962808061177 1582 1774255
SGTC_2425 5628681 7.85 µM 0.39529571534937 0.345878172228576 no 1153 0.346312330567228 1737 5714958
SGTC_2911 7942208 15.64 µM 0.394923291781786 0.346021286080163 no 1154 0.346449749962785 1604 1243384
SGTC_523 1934-0222 13.7 µM 0.394908463480322 0.34602698471245 no 1155 0.346455221829418 1597 1361595
SGTC_967 1306-0166 352 µM 0.394772122138759 0.34607938339113 no 1156 0.346505535340119 1765 4437607
SGTC_1941 st076221 61.8 µM 0.393996747568377 0.346377431213029 no 1157 0.346791720248192 1759 2828568
SGTC_1706 st031321 9.9705 µM 0.393969423892274 0.346387935953581 no 1158 0.346801806806871 1718 6103185
SGTC_1353 1498-1206 8.11 µM 0.39329034351517 0.346649050155396 no 1159 0.34705252478245 1621 6756808
SGTC_268 camptothecin 39.6153 µM 0.392027241799805 0.347134921013045 no 1160 0.347519042780551 1642 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_922 1866-0035 480 µM 0.391862561996209 0.347198286088986 no 1161 0.347579883182075 1668 3156169
SGTC_2869 9037858 32.47 µM 0.391427249969144 0.347365804910156 no 1162 0.347740726654557 1580 27187042
SGTC_3012 9080433 71.4286 µM 0.390405219768503 0.347759224520672 no 1163 0.34811846433946 1759 17688859
SGTC_2446 5162541 200 µM 0.388932492183152 0.348326423603751 no 1164 0.348663042753003 1603 1549321
SGTC_2464 5717415 7.67 µM 0.387100833875605 0.349032332934107 no 1165 0.349340780152913 1560 5285744
SGTC_972 1319-0219 195 µM 0.386554720300594 0.349242902869021 no 1166 0.349542942396 1610 23903702
SGTC_537 1334-0398 209 µM 0.386410096835315 0.349298674418725 no 1167 0.349596486769091 1764 5846986
SGTC_1695 st026914 34.495 µM 0.385679406974752 0.349580502117768 no 1168 0.34986705796776 1631 3289191
SGTC_33 0986-0033 35.816 µM 0.383752707915737 0.350324028850765 no 1169 0.350580871378064 1660 2848082
SGTC_441 propafenone 146 µM 0.383453076507226 0.35043971036394 no 1170 0.350691927864103 1623 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1167 k781-0610 148 µM 0.383059047717516 0.350591857878039 no 1171 0.350837991564941 1665 4525169
SGTC_2420 aureobasidin a 50 nM 0.382658788171805 0.350746435834654 no 1172 0.350986387536797 1772 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1978 st071761 42 µM 0.382543932021464 0.350790797189677 no 1173 0.351028974579484 1606 5147680
SGTC_2 0422-0095 29 µM 0.38230211571543 0.350884201528097 no 1174 0.351118642775979 1642 6790840
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.380589743010675 0.351545882817244 no 1175 0.35175384670682 1709 5377381
SGTC_2895 9054447 58.44 µM 0.377664863215359 0.352677131401482 no 1176 0.352839786509665 1669 2697450
SGTC_1367 1812-0510 76.9 µM 0.377646717974538 0.3526841534718 no 1177 0.352846527169586 1684 1142582 YDR527W RBA50
SGTC_1187 1391-0724 117 µM 0.377278059744446 0.352826832272077 no 1178 0.352983487666914 1689 6997986
SGTC_3051 9093778 49.47 µM 0.376178028100169 0.35325269155516 no 1179 0.353392274422417 1681 17217378
SGTC_2006 4011487 200 µM 0.375748125989082 0.35341917112258 no 1180 0.35355207791302 1781 45595294
SGTC_1345 1488-0192 31.4 µM 0.375667882445327 0.353450248537399 no 1181 0.35358190895479 1758 658348
SGTC_109 0132-0036 33.701 µM 0.375485345516762 0.353520946659393 no 1182 0.353649771554598 1669 67274 A color developer.
SGTC_1527 coumarin 137 µM 0.375225751905736 0.35362149820048 no 1183 0.353746289885139 1718 323 A hepatotoxic, DNA x-linker.
SGTC_1516 st013856 110 µM 0.375001209187081 0.353708481293536 no 1184 0.353829783685003 1661 5281404 A mutagen and neurotoxin.
SGTC_2909 7941780 10.49 µM 0.374662155138107 0.35383983812374 no 1185 0.353955870616159 1806 1243215
SGTC_585 0kpi-0023 191 µM 0.373193179025901 0.354409151900031 no 1186 0.354502336213162 1761 64601
SGTC_2434 5670830 169.91 µM 0.371647412596348 0.355008577841002 no 1187 0.355077691695495 1667 1549830
SGTC_2048 5246248 200 µM 0.371444016737712 0.355087478585073 no 1188 0.355153423065907 1771 677046
SGTC_180 1486-1293 102.781 µM 0.371210797863472 0.355177955836074 no 1189 0.355240265626437 1847 4140536
SGTC_339 3091-4833 71.4 µM 0.370183747801717 0.35557649695206 no 1190 0.355622792592084 1707 3240077
SGTC_3259 9138485 49.47 µM 0.369707939020304 0.355761185492129 no 1191 0.355800057904223 1767 17646153
SGTC_1290 0986-0249 10.2 µM 0.369030951554691 0.35602402131713 no 1192 0.356052327241352 1714 53329
SGTC_514 4466-0038 2.65 nM 0.36731700183307 0.356689756470813 no 1193 0.356691286751017 1718 5722064
SGTC_478 N-arachidonylglycine 10 µM 0.367024036289652 0.356803594393224 no 1194 0.356800544457515 1735 5283389
SGTC_55 0767-0285 6.563 µM 0.366864651634868 0.356865532009786 no 1195 0.356859989836056 1806 3116166
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.365991376457962 0.357204957733765 no 1196 0.357185755209565 1789 94937 An inhibitor of serotonin biosynthesis.
SGTC_1966 st070145 16.1 µM 0.365590424691082 0.357360838062585 no 1197 0.35733536060154 1630 3748532
SGTC_1707 st032323 6.317 µM 0.363930552734006 0.358006409045099 no 1198 0.357954934514295 1706 3132057 YMR211W DML1
SGTC_2432 5630864 12.22 µM 0.363361812811746 0.358227701570712 no 1199 0.358167312031588 1638 5714970
SGTC_3298 9116858 71.43 µM 0.363326746437133 0.358241347199129 no 1200 0.358180407871517 1770 2506942
SGTC_1152 3909-8331 15.9 µM 0.362725658157718 0.358475281106804 no 1201 0.358404915402734 1675 16001939
SGTC_1879 gemcitabine 100 µM 0.362451751595381 0.358581898766519 no 1202 0.358507236227152 1723 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3324 9138759 60.749 µM 0.362180378951178 0.358687540973465 no 1203 0.358608620496627 1701 45595710
SGTC_2026 5148700 152 µM 0.361218779564456 0.359061967394717 no 1204 0.358967952250227 1674 79838
SGTC_1749 st037932 54.2 µM 0.360616988386215 0.359296361048772 no 1205 0.359192893914642 1664 594497
SGTC_1594 piperine 70.1 µM 0.360343053096623 0.35940307456575 no 1206 0.359295303513854 1652 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_573 3702-0553 84.7 µM 0.360207638405632 0.359455830410752 no 1207 0.359345931482267 1690 1222756
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.359618804914386 0.359685263606843 no 1208 0.359566109444142 1742 1241132 A phosphatase inhibitor.
SGTC_1197 1601-0112 267 µM 0.359572818997639 0.359703183698722 no 1209 0.359583306566837 1638 7350313
SGTC_194 1486-1323 56.904 µM 0.358892352058798 0.359968388525714 no 1210 0.359837810594594 1659 5178754
SGTC_1521 st012942 49.4 µM 0.356682182240143 0.360830243499815 no 1211 0.360664872921816 1862 24207259
SGTC_1680 diphenhydramine 100 µM 0.35641725027891 0.360933601181853 no 1212 0.360764056321373 1682 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_508 roscovitine 141 µM 0.356073455039472 0.361067740868234 no 1213 0.360892777972878 1740 160355 A CDKinase inhibitor.
SGTC_696 1560-0013 611 µM 0.354186783271561 0.361804173410159 no 1214 0.361599453927882 1760 1650269
SGTC_3300 9124615 50.48 µM 0.353573327505962 0.362043736636543 no 1215 0.361829333153757 1767 24824903
SGTC_1443 4112-3303 14 µM 0.353527600499577 0.362061595850752 no 1216 0.361846470354355 1688 704433
SGTC_729 4092-0585 94.1 µM 0.353460630189387 0.362087752426354 no 1217 0.361871569449902 1647 2169061
SGTC_824 1304-0008 100 µM 0.35227935391038 0.36254922895023 no 1218 0.362314385091979 1708 768245
SGTC_2727 riluzole 51.77 µM 0.350450445969317 0.363264102653196 no 1219 0.363000336651552 1738 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2163 5671233 125 µM 0.350238033527758 0.36334716022088 no 1220 0.36308003276228 1806 701023
SGTC_2768 sulfasalazine 50.2 µM 0.350188145603131 0.363366668341906 no 1221 0.36309875132789 1835 5384001 An antioxidant and salicylic acid derivative.
SGTC_965 1291-5240 308 µM 0.348642469432293 0.363971263260365 no 1222 0.363678869945329 1798 2834598
SGTC_1907 st060210 83.7 µM 0.347574025242631 0.364389385877461 no 1223 0.364080058123725 1793 688793
SGTC_1059 3448-6867 171 µM 0.345071852953016 0.365369211431006 no 1224 0.365020176686155 1851 3934407
SGTC_1149 3909-7961 23.3 µM 0.34491274409985 0.365431546663862 no 1225 0.365079984732246 1652 735261
SGTC_2203 7227154 166.4 µM 0.344606035525718 0.365551718142436 no 1226 0.365195283872625 1724 896304
SGTC_1467 k284-1082 293 µM 0.342160270910048 0.366510464458815 no 1227 0.366115140972037 1826 3334705
SGTC_2931 9014674 55.67 µM 0.341637548369629 0.366715481428699 no 1228 0.366311838042602 1652 2996810
SGTC_676 falcarinol 140 µM 0.340892587431597 0.36700772821289 no 1229 0.366592222663855 1848 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_466 geldanamycin 89.2 µM 0.340823734334493 0.367034743048295 no 1230 0.3666181408407 1811 5288382 HSP90 inhibitor.
SGTC_1701 st028638 40.4 µM 0.338546590781244 0.367928561211888 no 1231 0.367475661593118 1813 3490878
SGTC_2481 5478948 45.16 µM 0.33793817060574 0.368167497976746 no 1232 0.367704890986616 1709 77792
SGTC_20 0481-0013 4.944 µM 0.334090971299913 0.369679534871904 no 1233 0.369155456448779 1683 182045
SGTC_992 3909-8734 162 µM 0.331971799529841 0.370513280869803 no 1234 0.369955276659196 1690 4288319
SGTC_834 0312-0008 75.7 µM 0.330766794112218 0.370987637960885 no 1235 0.370410322402834 1726 6385573 YIL048W NEO1
SGTC_531 3788-1495 174 µM 0.330755720658841 0.370991997997899 no 1236 0.37041450490896 1702 2896655
SGTC_1472 k841-0093 193 µM 0.33064104750222 0.371037150126382 no 1237 0.370457818511029 1830 X1472
SGTC_1781 st038725 66.3 µM 0.329243809341138 0.371587449892805 no 1238 0.37098570602346 1706 4270275 YIL048W NEO1
SGTC_1163 k060-0048 49.9 µM 0.328998298504519 0.371684171049128 no 1239 0.371078487055034 1726 6809982
SGTC_1960 st011366 51.8 µM 0.328982520223473 0.371690387318998 no 1240 0.371084450083591 1716 3972846
SGTC_1166 k206-0078 225 µM 0.328925360979604 0.371712906990454 no 1241 0.371106052328576 1694 5404595
SGTC_2147 5545932 89.7195 µM 0.327924612299258 0.372107254288518 no 1242 0.371484331935431 1744 797404
SGTC_1793 st048256 72.231 µM 0.326957713547903 0.372488390401269 no 1243 0.371849934319497 1745 672022
SGTC_25 0118-0223 35.662 µM 0.326852911514525 0.372529709205972 no 1244 0.371889568864989 1798 5333628
SGTC_186 3455-3465 67.277 µM 0.325902343123757 0.372904543209872 no 1245 0.372249121424114 1735 755278
SGTC_1704 st028805 70.8 µM 0.325754668052956 0.372962786167095 no 1246 0.372304989535048 1720 2876101
SGTC_1837 st055472 66.5 µM 0.324672845520295 0.373389544782971 no 1247 0.37271434416959 1794 676091
SGTC_1902 st060212 70.5 µM 0.324381144683344 0.373504641881136 no 1248 0.372824746509056 1725 688944
SGTC_2787 5284540 71.43 µM 0.323849803106502 0.373714323593206 no 1249 0.373025874428622 1717 736958
SGTC_176 1486-1328 72.834 µM 0.323392231764102 0.373894923544192 no 1250 0.373199105952785 1686 22310231
SGTC_3160 9100216 49.47 µM 0.322151345437091 0.374384831254518 no 1251 0.373669020929944 1795 17191039
SGTC_3113 9123498 49.47 µM 0.321922958230853 0.374475021719062 no 1252 0.373755530060399 1779 8897275
SGTC_1651 st011928 86.1 µM 0.321763046299456 0.374538175279141 no 1253 0.373816105725213 1771 720198
SGTC_809 3998-0021 90 µM 0.321505046957695 0.374640073313634 no 1254 0.373913844100406 1855 715485
SGTC_3299 9121982 43.1275 µM 0.320302578314671 0.375115109250374 no 1255 0.374369484412698 1709 17594604 YPL160W CDC60
SGTC_1563 conessine 56.1 µM 0.31695653233736 0.376437961873255 no 1256 0.375638292561518 1880 441082 An anti-amoebic, histamine inhibitor.
SGTC_3264 9137442 49.47 µM 0.316876471862087 0.37646963147759 no 1257 0.375668667738309 1843 17015726
SGTC_601 0986-0029 62.9 µM 0.314979788606255 0.377220147181815 no 1258 0.376388499863254 1750 24747981
SGTC_1878 temozolomide 1 mM 0.314592699429049 0.377373375094922 no 1259 0.376535461469403 1916 5394 DNA alkylating agent.
SGTC_2756 carbadox 75.1 µM 0.312309988925386 0.378277370039553 no 1260 0.377402474695509 1742 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1608 st001473 40.5 µM 0.311083258970294 0.378763453192316 no 1261 0.377868663798623 1696 7292267
SGTC_3159 9100096 49.47 µM 0.310995128335328 0.378798381734194 no 1262 0.377902162577223 1723 25236875
SGTC_1569 carminic acid 40.6 µM 0.310161744673226 0.37912872300502 no 1263 0.378218980132543 1898 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_675 1309-0189 238 µM 0.309074614181077 0.379559778537856 no 1264 0.378632384677652 1752 4246530
SGTC_1927 st060202 13.8 µM 0.307773755286801 0.380075775766474 no 1265 0.379127246549732 1902 688887
SGTC_2364 9055074 200 µM 0.307694108521748 0.380107375309378 no 1266 0.379157551552331 1706 6470630
SGTC_379 3970-0972 5.9 µM 0.306594984929795 0.380543529944836 no 1267 0.379575835683628 1790 2898042 YBL034C STU1
SGTC_2339 9000433 200 µM 0.30616423898804 0.380714500168054 no 1268 0.379739799485062 1700 2988954
SGTC_474 dl-dihydrosphingosine 5 µM 0.306043073739479 0.380762596868761 no 1269 0.379785925035988 1839 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_681 1642-0006 26.6 µM 0.301966034397921 0.382382052644462 no 1270 0.381338977812517 1762 4446530
SGTC_856 0433-0016 11.3 µM 0.300716490847729 0.38287880205338 no 1271 0.381815346321444 1782 3911780
SGTC_249 wiskostatin 11.211 µM 0.300646371058828 0.38290668352131 no 1272 0.381842083681882 1871 2775510 A n-wasp and actin depolymerizer.
SGTC_149 3970-0822 46.1 µM 0.299385340571505 0.38340820577206 no 1273 0.382323023027902 1754 3114250 YBL034C STU1
SGTC_3121 9125696 49.47 µM 0.299151978702331 0.383501037170932 no 1274 0.382412043906638 1899 1235365
SGTC_2078 5212016 200 µM 0.298846299803585 0.383622646416214 no 1275 0.382528661065263 1905 1899708
SGTC_2282 7944268 200 µM 0.298160481356327 0.383895529530601 no 1276 0.382790341030506 1855 2970414
SGTC_3216 9129716 49.47 µM 0.297981346122521 0.38396681587282 no 1277 0.382858700448713 1728 8056934
SGTC_2234 tolnaftate 200 µM 0.297745525922259 0.384060665817594 no 1278 0.382948696860705 1836 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2838 9002687 71.43 µM 0.297311248943186 0.384233513879776 no 1279 0.383114447157575 1710 6457060
SGTC_2080 5212524 12.4 µM 0.294947598434994 0.385174681344831 no 1280 0.384016955076914 1931 260183
SGTC_3028 9087778 49.47 µM 0.294730705905047 0.385261078431934 no 1281 0.384099802312709 1733 17217395
SGTC_5 0352-0601 109.883 µM 0.29442058318738 0.385384622774788 no 1282 0.38421827022488 1807 762456
SGTC_1298 1079-1278 263 µM 0.293417665083011 0.385784237278567 no 1283 0.384601462289117 1795 2840950
SGTC_2411 st077133 39.94 µM 0.292402634380494 0.386188801524718 no 1284 0.38498939712992 1933 1403142 YNL221C POP1
SGTC_2152 5568786 200 µM 0.290154377107259 0.387085337225467 no 1285 0.385849068630283 1819 5399883
SGTC_1332 1480-0653 17.5 µM 0.289461702102043 0.387361676342112 no 1286 0.386114041653022 1930 5749438
SGTC_606 k015-0008 38.6 µM 0.289193551511786 0.387468668969769 no 1287 0.386216633139642 1900 1970475
SGTC_127 0180-0333 59.125 µM 0.287136988615839 0.388289525312228 no 1288 0.387003715634573 1888 771601
SGTC_2136 5328288 199.296 µM 0.286974353205037 0.388354460945584 no 1289 0.387065978920349 1766 262395
SGTC_1547 harmine 94.2 µM 0.286797820010369 0.388424949095748 no 1290 0.3871335661181 1780 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1065 prochlorperazine maleate 2.48 µM 0.28586512027255 0.388797428833474 no 1291 0.387490714704201 1797 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1777 st045864 34.765 µM 0.284075120719422 0.389512563014178 no 1292 0.388176406334763 1804 4691462
SGTC_3333 9141820 12.094 µM 0.283754494339581 0.389640698108755 no 1293 0.388299264943709 1778 1939433
SGTC_2021 4019055 173 µM 0.283752668157699 0.389641427958274 no 1294 0.388299964737763 1838 44827708 YER133W GLC7
SGTC_905 2-aminofluorene 215 µM 0.283247141448192 0.389843481074563 no 1295 0.388493696829429 1781 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2260 7964312 200 µM 0.283008601798101 0.389938832926055 no 1296 0.388585121587062 1928 231951
SGTC_1847 st056231 15 µM 0.282755840620329 0.390039876799971 no 1297 0.388682003744711 1764 5393180
SGTC_1074 carmofur 3.8 µM 0.28250153286862 0.390141546431367 no 1298 0.388779485684853 1822 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1459 k035-0031 35.7 µM 0.28142395908307 0.390572432687944 no 1299 0.38919262184545 1720 3877128 YMR208W ERG12
SGTC_845 0330-0138 4.51 µM 0.280717540171684 0.390854979317969 no 1300 0.389463527191941 1925 9039800
SGTC_195 4234-0266 16.654 µM 0.279528714790219 0.391330604269071 no 1301 0.389919552338283 1820 2303354
SGTC_2531 methyl deoxycholate 70.07 µM 0.279201249574788 0.391461645049259 no 1302 0.390045192366977 1776 16667744 Haematoxylin.
SGTC_739 1486-1183 203 µM 0.27896309320735 0.391556955111863 no 1303 0.390136574090718 1945 4346692
SGTC_305 1682-2595 20.8 µM 0.277746038129629 0.392044121490682 no 1304 0.39060365856418 1851 226033
SGTC_2977 9011197 71.43 µM 0.277615825981749 0.392096253229464 no 1305 0.390653641074131 1888 2704722
SGTC_825 1988-2224 89.6 µM 0.277604190196232 0.392100911827135 no 1306 0.390658107609917 1810 1180859
SGTC_1975 st070967 30.8 µM 0.277505323432749 0.392140495552159 no 1307 0.390696059384552 1944 261391
SGTC_3222 9128301 49.47 µM 0.277371253553521 0.392194175488012 no 1308 0.390747526167843 1790 4911358
SGTC_131 0141-0277 33.849 µM 0.27732798797003 0.392211498935103 no 1309 0.390764135380838 1911 1547771
SGTC_969 1313-0238 134 µM 0.274676787142203 0.393273440456981 no 1310 0.391782283306043 1804 5212874
SGTC_1568 digitonin 820 nM 0.273849780377883 0.393604861919215 no 1311 0.392100033061471 1999 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2566 crystal violet carbinol 226 nM 0.273104272678354 0.393903688859813 no 1312 0.392386531207637 1690 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1652 st011932 78 µM 0.27247049550815 0.394157779234094 no 1313 0.392630137264366 1913 1551076
SGTC_777 1315-0167 517 µM 0.271767272038176 0.394439764353902 no 1314 0.39290048575317 1765 4221767
SGTC_796 1234-0020 70.7 µM 0.270184731309529 0.395074548471033 no 1315 0.393509069337313 1784 46495034
SGTC_1919 st067113 52.3 µM 0.269999445121908 0.395148888175649 no 1316 0.39358034024286 1799 1268243
SGTC_632 0781-2353 4.65 µM 0.266046625448134 0.396735726039827 no 1317 0.395101650316992 1883 6811515 YHR007C ERG11
SGTC_1395 3486-0190 4.35 µM 0.264838055818795 0.397221242602346 no 1318 0.395567109499191 1962 6748079
SGTC_513 4245-1575 41.7 µM 0.263477724471829 0.397767916681536 no 1319 0.396091195233556 1915 719745
SGTC_314 1671-0008 2.74 µM 0.261855926594925 0.398419928217269 no 1320 0.396716259860535 1872 3913060
SGTC_1337 1486-1011 40.3 µM 0.260392382722561 0.399008560454448 no 1321 0.397280559030996 1959 X1337
SGTC_1380 2291-0730 164 µM 0.259959003303226 0.399182908291844 no 1322 0.397447698626643 1799 2999191
SGTC_1276 0871-0068 94.2 µM 0.259342661874514 0.399430896082564 no 1323 0.397685432828811 1926 3414906
SGTC_2102 5377816 72.7585 µM 0.258960288434925 0.399584766188805 no 1324 0.397832940390359 1962 1379702
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.256371808638849 0.400626800021878 no 1325 0.398831877018076 1923 688751
SGTC_2587 piperic acid 92.2 µM 0.255939381278753 0.400800949732709 no 1326 0.398998822611897 1808 5370536
SGTC_1715 st032160 10.2275 µM 0.25510059487528 0.401138806953316 no 1327 0.399322702359213 1933 5289825
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.25406934141926 0.401554289854773 no 1328 0.399720994182636 1967 279621
SGTC_1172 0370-0043 85 µM 0.25279183771495 0.402069139123254 no 1329 0.400214537728112 1898 376585
SGTC_3016 9080866 49.47 µM 0.252241388450295 0.402291029207498 no 1330 0.400427244364975 1833 17066299
SGTC_296 1222-0039 74.9 µM 0.252095025806945 0.40235003435118 no 1331 0.400483807331208 1826 5984176
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.251917842942937 0.402421467442533 no 1332 0.400552283800573 1817 2374 Ca(2+)-ATPase inhibitor.
SGTC_1312 1218-2183 165 µM 0.251569163690298 0.402562050577719 no 1333 0.400687047991744 1947 6744073
SGTC_1028 k015-0029 4.8 µM 0.251505510017705 0.40258771630704 no 1334 0.400711651350635 1817 4588309
SGTC_1571 st070080 73.4 µM 0.251270743244728 0.40268237999582 no 1335 0.400802396592039 1928 4315245
SGTC_327 1273-0057 3.96 µM 0.249737577276453 0.403300729973137 no 1336 0.401395148144825 1944 3108138
SGTC_2258 7960471 200 µM 0.248252847611914 0.403899775367448 no 1337 0.401969389658474 1827 2974708
SGTC_821 1114-0266 29.2 µM 0.246630559371206 0.404554579394554 no 1338 0.402597076003682 1851 3123235
SGTC_1055 3448-0672 86 µM 0.246286309887674 0.404693563231618 no 1339 0.402730303373951 1893 748378
SGTC_1643 st009866 20.2 µM 0.245159568223644 0.405148546624033 no 1340 0.403166440541788 1964 3156273 YOR207C RET1
SGTC_2989 9073649 71.4286 µM 0.245111366856775 0.405168013418953 no 1341 0.403185100932747 2034 21367202
SGTC_1318 1280-3875 124 µM 0.244096916334721 0.405577767785639 no 1342 0.403577880367953 1899 373245
SGTC_2790 5423970 71.43 µM 0.243035081375139 0.40600677241145 no 1343 0.403989110507961 1968 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3257 9139206 32.98 µM 0.241992303046084 0.406428187617519 no 1344 0.404393063647116 1963 4910041
SGTC_2171 5739187 198.077 µM 0.241501822212415 0.406626441836524 no 1345 0.404583102176791 1835 2262761
SGTC_2993 9054257 71.4286 µM 0.241089398570651 0.406793163568449 no 1346 0.404742914596731 1868 6470217 YGL055W OLE1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.239326269877757 0.407506096230807 no 1347 0.405426298386348 1757 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1429 4049-0205 9.46 µM 0.239155594748424 0.407575126146541 no 1348 0.405492466936371 1944 22774478
SGTC_699 0375-0592 111 µM 0.237475889093278 0.408254639421132 no 1349 0.406143810995515 2058 762578
SGTC_2215 7188065 200 µM 0.236889001608709 0.408492125848196 no 1350 0.406371451311029 1969 940217
SGTC_924 2046-0044 21.3 µM 0.236335684247047 0.408716058770191 no 1351 0.406586099526752 1918 3623589
SGTC_2037 5169046 200 µM 0.235591499133119 0.409017284716178 no 1352 0.40687483525933 1919 5718022
SGTC_190 3970-0790 3.722 µM 0.235382704703512 0.409101808698902 no 1353 0.406955854329003 1989 2832352
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.235108419370911 0.409212851075695 no 1354 0.407062292062377 1983 140250 A respiratory chain inhibitor.
SGTC_722 3534-0461 190 µM 0.233508925112079 0.409860539271969 no 1355 0.40768311993088 1841 658262
SGTC_1121 fusaric acid 630.51 nM 0.232848776442441 0.410127927158382 no 1356 0.407939417802243 1842 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3227 9130768 49.47 µM 0.231143117826455 0.410818983595935 no 1357 0.408601809382828 1933 17720899
SGTC_1035 k081-0041 55.2 µM 0.229509340546623 0.411481176625909 no 1358 0.409236530830793 2015 731709
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.229489621366119 0.411489170632889 no 1359 0.409244193177172 1888 115019
SGTC_158 k038-0087 26.446 µM 0.229081206828901 0.41165474706124 no 1360 0.40940289994005 1893 X158
SGTC_1900 st060200 72.8 µM 0.228338224595062 0.411956001798693 no 1361 0.409691655209547 1863 688945
SGTC_1817 st052116 64.4 µM 0.228291179729686 0.411975078685479 no 1362 0.40970994054494 1990 4361398
SGTC_1371 2421-0008 32.7 µM 0.227119669868979 0.412450197740148 no 1363 0.41016534466805 1868 2827552
SGTC_429 1112-0049 25.5 µM 0.225829084236938 0.412973757847537 no 1364 0.410667177696587 1839 2836170
SGTC_785 1270-0111 65.3 µM 0.22517714095484 0.41323829475943 no 1365 0.410920735847932 1969 6741994
SGTC_2752 diclazuril 33.15 µM 0.224502877406915 0.413511929933738 no 1366 0.411183014104744 2027 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2728 chlorpromazine 9.18 µM 0.224075443921365 0.413685416268908 no 1367 0.411349299794661 1958 2726 A thorazine and dopamine antagonist.
SGTC_427 1354-0053 47.3 µM 0.223588977836184 0.413882883204146 no 1368 0.411538570485195 1991 6813657
SGTC_552 k242-0005 476 µM 0.223520291591315 0.413910766168067 no 1369 0.411565296090023 1907 4088318
SGTC_3253 9135987 49.47 µM 0.223105846861531 0.414079017900841 no 1370 0.411726563951814 1967 4182430
SGTC_1482 3346-2049 8.48 µM 0.223050502230008 0.414101487302589 no 1371 0.411748100667688 1993 3826804
SGTC_329 k048-0121 21.3 µM 0.22236911661839 0.414378146494284 no 1372 0.412013275673655 1904 6832902
SGTC_914 3820-6779 408 µM 0.222342967290296 0.414388764607216 no 1373 0.412023453015463 1900 2893481
SGTC_1604 st002052 72.4 µM 0.222242723837942 0.414429469723987 no 1374 0.412062468404644 1933 6254834 YHR062C RPP1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.221503385321566 0.414729715800899 no 1375 0.412350250479337 2004 16623 A steroid.
SGTC_1915 st067105 30.6 µM 0.21943230084567 0.415571049903975 no 1376 0.413156655329842 1938 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1182 1222-0449 220 µM 0.218646110014403 0.415890524837647 no 1377 0.413462865564175 1954 658318
SGTC_3305 9127027 53.8275 µM 0.218399721723251 0.415990658142031 no 1378 0.413558841169009 1919 41905295
SGTC_975 1335-0046 28.5 µM 0.218152498567446 0.416091136220837 no 1379 0.413655147169551 1835 16486740
SGTC_775 4577-0580 57.3 µM 0.217897526656733 0.41619476934522 no 1380 0.41375447714531 1978 2006902
SGTC_2009 4012297 12.05 µM 0.217271689019426 0.416449165229807 no 1381 0.413998309493755 1886 45595307
SGTC_483 fpl-64176 144 µM 0.216447555711713 0.416784219427442 no 1382 0.414319450304579 1988 3423
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.216201724065414 0.416884174836709 no 1383 0.414415254859165 1940 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2379 9035213 200 µM 0.215605134696471 0.417126771040285 no 1384 0.414647776514 2051 646551
SGTC_3098 9119039 49.47 µM 0.214817462605019 0.417447117155869 no 1385 0.41495481876584 1984 17161528
SGTC_2912 7964298 10.93 µM 0.214627985536186 0.417524185634669 no 1386 0.415028686531906 1894 2975850
SGTC_3064 1327-0027 10 µM 0.21285778301029 0.418244355872676 no 1387 0.415718946003254 1943 16000455 YPR107C YTH1
SGTC_2661 dactinomycin 12.96 µM 0.212436807451454 0.418415661505143 no 1388 0.415883136414848 1962 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2730 imipramine 71.33 µM 0.212141634225675 0.418535784208808 no 1389 0.415998269704394 2044 3696 A tricyclic antidepressant.
SGTC_3214 9129694 49.47 µM 0.209767258341003 0.419502327659231 no 1390 0.416924664278353 2040 17158655
SGTC_3140 9094243 49.47 µM 0.208802614173905 0.419895147035116 no 1391 0.417301165251527 2108 19291112
SGTC_1154 4088-0362 150 µM 0.207530915974056 0.420413125912594 no 1392 0.417797625368928 1987 6618304
SGTC_794 k038-0031 316 µM 0.207442415240889 0.420449178529506 no 1393 0.417832180185341 1934 6624242
SGTC_2386 9075165 157.42 µM 0.207322874527159 0.420497876988451 no 1394 0.417878855465864 1967 16452277
SGTC_27 0485-0001 32.618 µM 0.207003180327194 0.420628119889469 no 1395 0.418003687376386 2049 2054479
SGTC_2305 7443522 69.23 µM 0.205460601113847 0.421256686040909 no 1396 0.418606138586982 1972 5415886
SGTC_1722 st034304 3.6505 µM 0.205438736184504 0.421265596951839 no 1397 0.418614679267042 1918 4036148 YLR033W RSC58
SGTC_426 0988-0037 14.6 µM 0.20510470559475 0.421401733975731 no 1398 0.418745160028944 2108 5383008
SGTC_762 1165-0429 115 µM 0.205038982314713 0.42142852116743 no 1399 0.418770834250526 2050 5967793
SGTC_2807 7945238 51.95 µM 0.203180607899916 0.422186098906747 no 1400 0.419496934680602 1950 17148797
SGTC_1620 st003704 16.5 µM 0.201047476350983 0.423056037942266 no 1401 0.420330725564096 2054 2834414
SGTC_932 2857-0803 154 µM 0.200788363383331 0.423161735687478 no 1402 0.420432031154262 2048 674898
SGTC_920 mycophenolic acid 780.421 nM 0.199845109981259 0.423546555668942 no 1403 0.42080086010901 1903 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3078 9116413 49.47 µM 0.198922262844578 0.423923121074376 no 1404 0.421161777143504 2017 17177322
SGTC_223 busulfan 5 mM 0.198306036898213 0.424174609196915 no 1405 0.421402814361639 2021 2478 A DNA alkylator.
SGTC_1936 st074407 74.3 µM 0.197276873620304 0.42459469007606 no 1406 0.421805437946975 1872 809813
SGTC_3131 9127911 49.47 µM 0.195769506050603 0.425210117482432 no 1407 0.422395289423687 1983 45595681
SGTC_3052 9092717 49.47 µM 0.195046461052491 0.425505386780669 no 1408 0.4226782876879 1943 25237534
SGTC_2850 9015429 58.44 µM 0.194332984028662 0.42579678977212 no 1409 0.422957580192633 1941 6457570
SGTC_1840 st055363 71 µM 0.192730345873901 0.426451497350666 no 1410 0.423585078207985 1892 676033
SGTC_1934 st074720 32.6 µM 0.190638183048925 0.4273064896994 no 1411 0.424404536511798 1934 17250992
SGTC_3340 9146634 11.102 µM 0.190092656475812 0.427529483262276 no 1412 0.424618262224318 1955 4907387
SGTC_2732 terfenadine 20 µM 0.189884518237556 0.427614569526901 no 1413 0.424699812205584 2063 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2797 7859098 81.82 µM 0.188914248410074 0.42801125718089 no 1414 0.425080013019668 1953 972681
SGTC_597 k018-0003 82.8 µM 0.187761472421313 0.428482655687435 no 1415 0.42553181954839 2046 6786234
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.186804046263515 0.428874248446813 no 1416 0.425907137152668 2062 6728940
SGTC_2867 9039098 71.43 µM 0.186182590100816 0.42912846506302 no 1417 0.426150788170371 1928 6463460
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.185917705086988 0.429236829470762 no 1418 0.426254648805849 2023 4620898
SGTC_1328 1441-0025 69.2 µM 0.185724274204149 0.429315965377058 no 1419 0.426330495718318 2001 4562601
SGTC_104 0074-0074 590.992 µM 0.185095363756835 0.429573283092576 no 1420 0.426577118981963 2090 3943124
SGTC_2627 acetyl isogambogic acid 100 µM 0.185093813488728 0.429573917419338 no 1421 0.426577726945331 1920 6857789 A caspase activator and apoptosis inducer.
SGTC_2636 apigenin dimethyl ether 100 µM 0.183758086909975 0.430120527129724 no 1422 0.427101618971396 1996 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_926 2268-1401 59.4 µM 0.183226732025222 0.43033800693973 no 1423 0.427310060143685 2097 2931578
SGTC_2271 7849410 118.62 µM 0.180789276866224 0.431335909995567 no 1424 0.428266490119085 2134 972430
SGTC_1259 0671-0132 43 µM 0.179729930942503 0.431769747149104 no 1425 0.428682297282253 1947 X1259
SGTC_414 piperonyl butoxide 100 µM 0.179271109475417 0.431957675272702 no 1426 0.428862415322251 1952 5794 A potent inhibitor of cytochrome P450.
SGTC_120 rhodamine 6G 52.259 µM 0.179102501379322 0.43202673912785 no 1427 0.428928608974706 2110 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1647 st011722 22.4 µM 0.178682279208382 0.432198876097444 no 1428 0.429093592193734 2042 2854783
SGTC_432 NS 1619 61.3 µM 0.177952583407613 0.432497814315653 no 1429 0.429380107118488 1979 4552 A K+/calcium channel activator.
SGTC_1286 0929-0070 131 µM 0.177444127639447 0.432706138851147 no 1430 0.429579774188666 2037 1420408
SGTC_511 blebbistatin 171 µM 0.176932464626305 0.432915796342858 no 1431 0.429780718907785 2070 3476986 A myosin inhibitor.
SGTC_105 0111-0055 734.78 µM 0.175551713072797 0.433481663011999 no 1432 0.430323070229655 2013 5179370
SGTC_2998 9066762 71.4286 µM 0.175355903937334 0.433561921582781 no 1433 0.430399993607378 2062 4945196
SGTC_2478 5763493 32.33 µM 0.175251733887603 0.43360462009089 no 1434 0.430440917759668 2026 1365576 YLR208W SEC13
SGTC_1468 k284-1086 134 µM 0.175063303701373 0.43368185815391 no 1435 0.43051494617131 1972 15996457
SGTC_1108 betulinic acid 729.144 nM 0.174327726324219 0.4339833976018 no 1436 0.430803955197882 1976 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2817 7995342 71.43 µM 0.173203926545503 0.434444157413935 no 1437 0.431245568676316 1961 18879975
SGTC_3189 9110682 49.47 µM 0.172740246588382 0.434634292972003 no 1438 0.431427803547006 1966 17122418
SGTC_1876 myriocin 605 nM 0.172446664013269 0.43475468660075 no 1439 0.431543194523626 2118 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_811 0416-0114 265 µM 0.172344842474329 0.434796443437186 no 1440 0.431583216270619 1982 6612453
SGTC_1787 fluconazole 80 µM 0.172242912678747 0.434838245397944 no 1441 0.43162328127217 2020 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1226 3909-7979 35.4 µM 0.171596781163243 0.43510324435295 no 1442 0.431877269088958 2087 6615510
SGTC_731 3966-0296 387 µM 0.171377258882858 0.435193284018453 no 1443 0.431963567509706 2022 660956
SGTC_2120 5538279 151.968 µM 0.170833075166392 0.435416501900899 no 1444 0.432177510562177 2016 2058197
SGTC_1300 1094-0077 113 µM 0.169090565131591 0.436131397525811 no 1445 0.432862703003642 1987 5532636
SGTC_1612 st002233 45.4 µM 0.167422507672737 0.436815943224681 no 1446 0.433518808276641 2113 1035021
SGTC_1926 methyl fluorone black 53.6 µM 0.167009610951611 0.43698541912879 no 1447 0.433681243345623 2043 72721 Reacts with homocysteine.
SGTC_1697 st025554 27.742 µM 0.166454262980392 0.437213383224799 no 1448 0.433899736913693 2050 1269519
SGTC_751 0833-0568 350 µM 0.165125125419202 0.437759063758589 no 1449 0.434422748618794 2007 6954252
SGTC_2139 5578692 56.4705 µM 0.164261047350886 0.438113876596909 no 1450 0.434762822418409 2140 650991 YMR113W FOL3
SGTC_343 4130-2827 29.8 µM 0.161715199323728 0.439159555951324 no 1451 0.435765067381841 1972 1118244
SGTC_2702 st077768 96.8 µM 0.161188630499614 0.439375891610471 no 1452 0.435972417786492 1990 6484119
SGTC_119 0121-0043 24.815 µM 0.158596391495892 0.440441150460873 no 1453 0.43699343599079 2141 1092378
SGTC_2970 9090938 41.86 µM 0.157847883950019 0.440748823922849 no 1454 0.437288332832699 2154 17217104
SGTC_1047 2043-3044 82 µM 0.157160140887916 0.44103155172755 no 1455 0.437559320416215 2009 669592
SGTC_1113 artemisinin 1.17947 µM 0.155944704269475 0.441531285179307 no 1456 0.438038303712241 2158 2240 An anti-malaria and mitochondrial poison.
SGTC_2328 6201408 200 µM 0.155606710847693 0.441670269611033 no 1457 0.438171517446085 2010 2890418
SGTC_1114 scopoletin 1.73284 µM 0.154982892732358 0.441926805304464 no 1458 0.438417401981444 2147 5280460 A coumarin with genotoxic properties.
SGTC_1479 0549-0158 134 µM 0.154916293673773 0.441954194593395 no 1459 0.438443654113856 2035 5440202
SGTC_1854 st056233 32.9 µM 0.153533264253686 0.442523036819003 no 1460 0.43898888009437 2164 5393174
SGTC_594 1487-1584 10.8 µM 0.153491267625552 0.442540311959708 no 1461 0.439005438068252 1981 5013332
SGTC_664 1222-0054 14.9 µM 0.152693390326223 0.442868536232005 no 1462 0.439320036698191 2082 6813991
SGTC_2101 5377231 179.231 µM 0.152632180260983 0.442893717953004 no 1463 0.439344173075741 2083 2844213
SGTC_3044 9093193 49.47 µM 0.152054307204799 0.443131465340869 no 1464 0.439572051313143 1978 25236277
SGTC_1068 loratadine 26.9 µM 0.151664354703733 0.443291910402044 no 1465 0.439725836351423 2006 3957 A H1 histamine antagonist.
SGTC_2601 securinine 100 µM 0.151425771846025 0.443390079357331 no 1466 0.439819930435218 2014 442872 A GABA receptor antagonist.
SGTC_2217 6934799 96.0675 µM 0.150323275834556 0.443843765035932 no 1467 0.440254785088961 2136 675606
SGTC_400 oxethazaine 37.5 µM 0.150121423866036 0.443926836679434 no 1468 0.44033440886065 2035 4621 A local anesthetic.
SGTC_517 1365-0151 113 µM 0.149938195038958 0.444002246151788 no 1469 0.440406688522435 2046 768657
SGTC_979 1426-2828 121 µM 0.149010591741186 0.444384040692341 no 1470 0.440772637637971 2086 747872
SGTC_1940 st075990 51.1 µM 0.148852735148765 0.444449018427152 no 1471 0.440834918745107 2078 1084979
SGTC_2734 clemastine 41.6 µM 0.148648915937405 0.444532917737444 no 1472 0.440915336215269 2150 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_828 2074-0507 139 µM 0.147723855326233 0.444913737103259 no 1473 0.441280352179569 2143 X828
SGTC_1774 st048371 48.465 µM 0.147020964036969 0.445203130119955 no 1474 0.441557736608641 2024 4242727
SGTC_3002 9075603 71.4286 µM 0.1463156031611 0.445493569268471 no 1475 0.441836124436662 2160 20105405
SGTC_2297 7971671 152.32 µM 0.145756369074623 0.445723860101351 no 1476 0.442056860199804 2119 909016
SGTC_1143 3454-2408 5.08 µM 0.145309706379 0.445907807549017 no 1477 0.442233175741433 2124 X1143
SGTC_3057 9095946 49.47 µM 0.144397287917523 0.446283601616095 no 1478 0.442593379147663 2155 24540043
SGTC_489 paxilline 115 µM 0.144275299281726 0.446333848241752 no 1479 0.442641541270292 2025 105008 A toxic potassium channel blocker.
SGTC_300 r073-0011 5.04 µM 0.143787042880929 0.446534967697222 no 1480 0.442834317415682 2180 2735780
SGTC_2109 5483026 200 µM 0.14278160647755 0.446949163898368 no 1481 0.443231332067024 2043 759335
SGTC_1393 3470-5649 58.2 µM 0.142305523924973 0.44714530948416 no 1482 0.443419341736056 2063 4108395
SGTC_2197 6588183 93.1375 µM 0.142221223279314 0.44718004262347 no 1483 0.443452634216427 2090 884136
SGTC_1031 k035-0009 16 µM 0.142121910669756 0.447220961438377 no 1484 0.443491855817258 2142 5180959
SGTC_2907 7721985 69.9 µM 0.141750560397827 0.447373970277137 no 1485 0.443638518351184 2007 3267881
SGTC_3309 9129340 25.759 µM 0.140664912772002 0.447821338559555 no 1486 0.4440673324909 2093 17158987
SGTC_2367 9070478 135.38 µM 0.139963409875375 0.448110445729417 no 1487 0.444344450223545 2064 572802
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.138824846397505 0.448579735277951 no 1488 0.444794279755 2139 16486 A toxic proline analog.
SGTC_294 k038-0071 157 µM 0.138714442704805 0.448625244965841 no 1489 0.444837902406306 2053 24152826
SGTC_1658 st012944 20 µM 0.13779876527326 0.449002723866993 no 1490 0.445199730110024 2133 24207260
SGTC_2949 9072542 2.23 µM 0.137615677020767 0.449078205724605 no 1491 0.445272082473276 2060 16457352
SGTC_159 3970-0959 50 µM 0.136727249302069 0.44944450424952 no 1492 0.445623194986151 2132 6615653
SGTC_562 3772-2733 112 µM 0.136300292430429 0.449620553808018 no 1493 0.445791946358045 2152 2876874 YIL048W NEO1
SGTC_2781 5567276 71.43 µM 0.135723876674928 0.449858246324392 no 1494 0.446019785760987 2113 2853274
SGTC_450 aminopyrene 156 nM 0.135271308341043 0.450044881361214 no 1495 0.446198684586506 2159 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2131 toluylene red 5.2905 µM 0.135128843766696 0.450103634735654 no 1496 0.446255002648656 2040 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3170 9103054 49.47 µM 0.135103987947275 0.450113885559343 no 1497 0.446264828582008 2054 16432970
SGTC_453 enantio-paf c16 10 µM 0.134343176301064 0.450427669036724 no 1498 0.446565606458444 2159 13871343 A lipid and platelet activating factor
SGTC_563 tetrahydrosecaminediol 614 µM 0.134335045419859 0.450431022644396 no 1499 0.446568821072403 2162 334274 A psychoactive constituent of the cannabis plant.
SGTC_1107 amlodipine 47 µM 0.131949776095462 0.451414986335911 no 1500 0.447512008579955 2124 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_670 4204-0025 119 µM 0.130129611742652 0.45216603591023 no 1501 0.448231941261776 2135 719039
SGTC_157 1348-1695 65.819 µM 0.129093484179189 0.452593647112204 no 1502 0.44864183886986 2183 5380510
SGTC_750 4073-0104 132 µM 0.128938353651906 0.452657674428764 no 1503 0.448703214066265 2173 22330957
SGTC_3166 9102297 49.47 µM 0.128756783090455 0.452732615954235 no 1504 0.448775051447026 2042 25237072
SGTC_1051 3253-3903 78 µM 0.128067748765011 0.453017023626823 no 1505 0.449047679297824 2173 5509239
SGTC_2257 7960413 200 µM 0.126830178496006 0.453527906906886 no 1506 0.449537404812841 2105 2974689 YIL048W NEO1
SGTC_1843 st055809 45.5 µM 0.126376823625391 0.453715076319865 no 1507 0.449716823558097 2081 16413835
SGTC_835 0312-0010 67.2 µM 0.126352748612429 0.453725016075292 no 1508 0.449726351721039 2112 1626196
SGTC_799 1310-0557 151 µM 0.125729498532637 0.45398234494223 no 1509 0.44997302534907 2079 5354492
SGTC_567 1080-0542 68.4 µM 0.124729038972159 0.454395457241734 no 1510 0.450369033571505 2192 5950415
SGTC_2873 9040596 71.43 µM 0.122892176699309 0.455154067198609 no 1511 0.451096240378599 2017 6463863
SGTC_313 3474-0040 5.03 µM 0.120505282069403 0.456140080243707 no 1512 0.452041447826138 2148 1043375 YIL048W NEO1
SGTC_2172 5754775 163.918 µM 0.120336378686481 0.456209863608635 no 1513 0.452108343729512 2079 2263357
SGTC_3281 9140613 49.47 µM 0.120145627770219 0.456288675026551 no 1514 0.452183894205537 1988 16013766
SGTC_3032 9089427 49.47 µM 0.119958034008217 0.456366183699129 no 1515 0.452258195920178 2094 17173707
SGTC_2800 7887935 81.82 µM 0.119764383514869 0.456446196590964 no 1516 0.452334898325204 2101 2961002
SGTC_1303 1160-0052 261 µM 0.118906002007652 0.456800885570405 no 1517 0.452674913293209 2201 3562476
SGTC_361 000s-0510 1.45 µM 0.11800327440719 0.457173935779263 no 1518 0.453032531705309 2106 660
SGTC_2868 9035608 32.47 µM 0.117846181124103 0.457238858099833 no 1519 0.453094768609189 2209 6462614
SGTC_1682 st012968 530 nM 0.11774444950027 0.457280901582669 no 1520 0.45313507305598 2014 24207270
SGTC_78 0336-0123 156.75 µM 0.117487725770678 0.457387002079765 no 1521 0.453236785048495 1989 6765896
SGTC_2001 4023502 57.655 µM 0.117290715073695 0.457468426036186 no 1522 0.453314841271699 2132 108941 YCR052W RSC6
SGTC_1354 1498-1681 81 µM 0.116809393633879 0.457667362309803 no 1523 0.45350554983585 2094 5754243
SGTC_3346 9158254 43.5805 µM 0.116757471006393 0.457688823226904 no 1524 0.45352612319429 2113 17639500
SGTC_829 1635-0120 117 µM 0.116310347627941 0.457873635571136 no 1525 0.453703292526346 2191 285054
SGTC_280 3448-3607 3.04 µM 0.115317678759575 0.458283974197431 no 1526 0.454096663109012 2196 626179
SGTC_357 1325-0123 420 µM 0.11517849912462 0.458341510320349 no 1527 0.454151820229109 2193 1098503
SGTC_2091 4-phenylthiadiazole 200 µM 0.114439156417171 0.458647165279266 no 1528 0.454444837768656 2123 270010
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.113676357350855 0.458962543061256 no 1529 0.454747177555415 2152 6708561
SGTC_1686 st019653 115.5 µM 0.111069522467685 0.460040527620332 no 1530 0.455780608360009 2215 97252
SGTC_2143 5623677 140.463 µM 0.108182570467753 0.461234689402321 no 1531 0.456925435278775 2205 5375313
SGTC_207 4185-0010 4.486 µM 0.108070687170413 0.461280976030705 no 1532 0.456969810095709 2221 3761753
SGTC_2455 5377712 9.75 µM 0.105646180873674 0.462284133080467 no 1533 0.457931541355465 2042 2243908
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.104395756562675 0.46280159939397 no 1534 0.458427645027918 2235 6708630 An antioxidant.
SGTC_430 0958-0115 16.4 µM 0.104271181740954 0.462853155976165 no 1535 0.458477073432122 2051 6833180
SGTC_1415 3966-0071 78.1 µM 0.103521042840134 0.463163621903024 no 1536 0.458774724721963 2219 2893185
SGTC_631 k072-0230 41.5 µM 0.103379567380632 0.463222177992411 no 1537 0.458830864058571 2168 5773147
SGTC_2936 9038235 15.59 µM 0.103272555689661 0.463266470204367 no 1538 0.458873328260725 2221 4749415
SGTC_2188 6126565 140.678 µM 0.10280650949185 0.463459372346757 no 1539 0.459058269407947 2208 874518
SGTC_1052 3253-3998 198 µM 0.100286460749341 0.464502598604753 no 1540 0.460058453028999 2219 5450317
SGTC_2519 cryptotanshinone 88.04 µM 0.100098232429704 0.464580529492393 no 1541 0.460133169301339 2207 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_881 0833-0569 170 µM 0.0998671495308118 0.464676205026926 no 1542 0.460224898405291 2026 5418700
SGTC_2246 7293507 91.5585 µM 0.0988331449074504 0.465104340160098 no 1543 0.460635375743982 2245 887656
SGTC_1623 st003709 20.3 µM 0.0981987754609234 0.46536702424239 no 1544 0.460887227403362 2153 16192618
SGTC_3342 9147791 14.508 µM 0.0977198286115503 0.465565359866876 no 1545 0.461077384979115 2219 1838168
SGTC_3350 9150499 3.57 µM 0.0973689927540459 0.465710649161343 no 1546 0.461216683947818 2236 4910996 YPR165W RHO1
SGTC_1759 st043059 70 µM 0.0965999586483708 0.466029140047015 no 1547 0.46152204466813 2150 669426
SGTC_2094 5332512 191.667 µM 0.0946637389959136 0.466831109757771 no 1548 0.462290960340758 2215 755774
SGTC_1221 2958-7315 257 µM 0.0944509897763056 0.466919237385364 no 1549 0.462375456410105 2166 4562705
SGTC_2399 5884133 200 µM 0.0931157176491092 0.46747238727006 no 1550 0.462905815404466 2143 722445
SGTC_3067 9117431 49.47 µM 0.0926553392642373 0.467663118255413 no 1551 0.463088689209411 2142 17150885
SGTC_2040 5100729 123 µM 0.0924076294542072 0.467765745470852 no 1552 0.463187088969571 2177 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_990 3985-0011 41.3 µM 0.0922585327245495 0.467827517905944 no 1553 0.463246316948933 2192 5399565 YGL099W LSG1
SGTC_1021 4476-0760 85.3 µM 0.0920801928826051 0.467901407105462 no 1554 0.463317162688005 2135 746768
SGTC_1645 Cervolide 78 µM 0.0914965706724709 0.468143219332372 no 1555 0.463549015507646 2164 23173 A fragrance.
SGTC_3000 9075062 71.4286 µM 0.0909115512419097 0.468385622266523 no 1556 0.463781435819973 2136 17057871
SGTC_152 4469-0003 551.229 µM 0.0903232880695821 0.468629381064811 no 1557 0.464015157291524 2270 697280
SGTC_2226 7298446 200 µM 0.0900780427067737 0.468731006942789 no 1558 0.464112598828221 2251 3283010
SGTC_2502 avocadyne acetate 18.59 µM 0.0900060821157484 0.468760826683521 no 1559 0.464141190809463 2253 3952079
SGTC_2851 9015922 71.43 µM 0.0898591861711531 0.468821699420326 no 1560 0.464199557304075 2216 2996893
SGTC_445 e6 berbamine 66 µM 0.0896011207289347 0.46892864184772 no 1561 0.464302096889018 2167 6610268 A calcium/calmodulin antagonist.
SGTC_2122 5258151 111.688 µM 0.0889206396677063 0.469210644214102 no 1562 0.464572490221619 2179 2173356
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0887682395365192 0.4692738034174 no 1563 0.464633049597463 2180 688667
SGTC_2387 9077560 195.08 µM 0.0881736351035489 0.469520232777275 no 1564 0.464869335911488 2168 5303272
SGTC_1001 4048-4355 44.4 µM 0.0876186199329791 0.469750265201029 no 1565 0.465089901264646 2230 21824233
SGTC_2431 5490079 200 µM 0.0868522251153027 0.470067922932324 no 1566 0.465394487392657 2186 5722345
SGTC_129 0088-0017 176.636 µM 0.0863176230514033 0.470289517765875 no 1567 0.465606964795846 2259 182446
SGTC_2818 7996756 12.99 µM 0.0847263981319646 0.4709491414597 no 1568 0.466239454373925 2232 2241621
SGTC_2013 4024628 200 µM 0.0847261844984464 0.47094923002437 no 1569 0.466239539296011 2194 5230760
SGTC_1732 st034308 51.822 µM 0.0844178808655653 0.471077042968734 no 1570 0.466362095577711 2074 830119
SGTC_2138 5575593 77.673 µM 0.0803244201925542 0.472774339709686 no 1571 0.467989618228823 2243 762213
SGTC_1448 4255-0083 152 µM 0.0781383827528901 0.473680954341211 no 1572 0.468858987746885 2261 5399660
SGTC_1884 5633444 25 µM 0.0764769681361864 0.474370083748292 no 1573 0.469519818533687 2216 5724239
SGTC_1556 plumbagin 1.48 µM 0.076047390454166 0.474548278571317 no 1574 0.469690697599766 2272 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1391 3442-0225 151 µM 0.0758691434515574 0.474622219414608 no 1575 0.469761603020015 2225 5227075
SGTC_150 3970-0969 77.2 µM 0.074745881861974 0.475088193452174 no 1576 0.470208450652503 2164 6615640
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0745100470026596 0.475186031576914 no 1577 0.470302273519355 2259 688798
SGTC_756 0508-1999 28.3 µM 0.0725521498484339 0.475998339315177 no 1578 0.471081252600858 2142 6753853
SGTC_1709 st033179 39.1045 µM 0.0720045994621108 0.476225529312819 no 1579 0.471299123756722 2285 573381
SGTC_1455 4262-0120 131 µM 0.0719430545469885 0.476251066057536 no 1580 0.471323613113017 2245 1529587
SGTC_1066 ketoconazole 628 nM 0.0706510370461873 0.476787183410847 no 1581 0.471837745087908 2256 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2381 9035592 200 µM 0.0706350103616883 0.476793833883572 no 1582 0.471844122876124 2119 4749657
SGTC_872 0588-0139 234 µM 0.0705003973275641 0.476849693496836 no 1583 0.471897692158518 2290 2047100
SGTC_1979 st071809 45.3 µM 0.0693260485702927 0.477337025567062 no 1584 0.4723650459265 2259 4976333
SGTC_1202 1988-0068 29.6 µM 0.0693005515901579 0.477347606700302 no 1585 0.472375193344806 2193 2850480
SGTC_1199 1638-0010 4.46 µM 0.0678614349251355 0.477944859374516 no 1586 0.472947969211086 2240 3111136
SGTC_2699 st077704 54.6 µM 0.0670646109036808 0.478275573399477 no 1587 0.473265133424759 2226 645852
SGTC_3006 9075424 71.4286 µM 0.0668656801114812 0.478358140023572 no 1588 0.473344317585339 2221 7465181
SGTC_890 0929-0006 47.2 µM 0.0668501922374647 0.478364568335749 no 1589 0.473350482559043 2216 1378169
SGTC_1757 st041620 31.8375 µM 0.0660841038789645 0.478682543765768 no 1590 0.473655433225796 2212 5289815
SGTC_1972 st070201 17.4 µM 0.0659914284067637 0.478721010909529 no 1591 0.473692324860274 2286 2829099
SGTC_114 0364-0001 490.298 µM 0.0640138602458925 0.479541893949806 no 1592 0.474479595281741 2160 4003655
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0638863086248477 0.479594843289061 no 1593 0.474530377071096 2241 2724 A muscle relaxant with antifungal properties.
SGTC_1432 4049-0298 68.4 µM 0.0628295572725869 0.480033536586881 no 1594 0.474951114529834 2310 741646
SGTC_1232 0279-0259 161 µM 0.0623827744901711 0.480219018565495 no 1595 0.475129006102726 2235 1560000
SGTC_2962 9082311 13.18 µM 0.0608465996561091 0.480856794345552 no 1596 0.475740688944324 2240 16459453
SGTC_12 0849-0099 9.267 µM 0.0606385805541205 0.48094316172031 no 1597 0.475823523602088 2307 6071388
SGTC_1045 1348-1485 165 µM 0.0604272842900358 0.481030890654557 no 1598 0.475907664318347 2310 6810614
SGTC_2086 5274770 176.623 µM 0.0595030725816744 0.481414628522101 no 1599 0.476275709124652 2239 689278
SGTC_1014 4130-3005 69.3 µM 0.058314280206133 0.481908247034052 no 1600 0.476749146456235 2291 743608
SGTC_666 0272-0154 136 µM 0.0576159680927327 0.482198217952871 no 1601 0.477027265051786 2237 6870312
SGTC_2406 ethylparaben 405.7 µM 0.0575275753246198 0.482234923321185 no 1602 0.477062470271877 2101 8434 A possible steroid mimic.
SGTC_2210 7115885 190.385 µM 0.0574298110680047 0.482275520404236 no 1603 0.477101408192627 2288 2927039
SGTC_1098 clofazimine 15.1 µM 0.0571186829210104 0.482404719101594 no 1604 0.477225326950026 2290 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3197 9113331 49.47 µM 0.0569831207635043 0.482461013057631 no 1605 0.477279320485473 2277 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2742 clothiapine 36.27 µM 0.0563258404376368 0.482733962233082 no 1606 0.477541116907574 2307 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1474 0330-0125 5.35 µM 0.0557117450718399 0.482988985280656 no 1607 0.477785721410771 2317 X1474
SGTC_3174 9107204 49.47 µM 0.0549192787124618 0.483318092948192 no 1608 0.478101386432622 2286 3938802
SGTC_2005 4024620 188 µM 0.054354271099011 0.483552744989153 no 1609 0.478326455668782 2306 236743
SGTC_1446 4239-0190 62 µM 0.0541503169716113 0.483637450122599 no 1610 0.478407701938764 2235 1340085
SGTC_2110 5483698 200 µM 0.0540092186138473 0.483696050767583 no 1611 0.478463909785866 2250 2848765 YHR062C RPP1
SGTC_1428 4049-0204 61.7 µM 0.0533511679927942 0.483969355466903 no 1612 0.478726056028829 2314 X1428
SGTC_1277 0873-0036 22 µM 0.0526582458693834 0.484257151302401 no 1613 0.479002103904766 2281 5965735
SGTC_2280 7785178 200 µM 0.0523235235989504 0.484396176618964 no 1614 0.479135454932834 2280 2954328
SGTC_3106 9121286 49.47 µM 0.0510053003427434 0.484943712716974 no 1615 0.479660648492494 2284 15943471
SGTC_422 cantharidin 155 µM 0.0506729520953961 0.485081761125832 no 1616 0.479793065025954 2328 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1540 guanosine 70.6 µM 0.050111884727552 0.485314817275648 no 1617 0.480016614497642 2309 6802 Guanosine is a purine nucleoside
SGTC_1505 k297-0037 20.6 µM 0.0500370169722269 0.48534591622314 no 1618 0.480046444987978 2276 4089396
SGTC_2030 5175110 200 µM 0.0496409442794582 0.485510440383304 no 1619 0.480204259009427 2274 2831986
SGTC_754 3474-0146 171 µM 0.0487331096292237 0.485887553988745 no 1620 0.480565994772663 2303 24762078
SGTC_1190 1486-1332 13 µM 0.0482316763689127 0.48609585429583 no 1621 0.480765802732318 2296 4150046
SGTC_1545 lovastatin 49.4 µM 0.0481555741616495 0.486127468234044 no 1622 0.480796127882979 2289 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2274 7947094 46.08 µM 0.0464325903198726 0.486843243152144 no 1623 0.481482730599017 2326 2971028
SGTC_706 4262-0057 46.9 µM 0.0455283699309718 0.487218898298002 no 1624 0.481843081201834 2322 883298
SGTC_627 1391-0720 175 µM 0.0444234241486762 0.487677959457727 no 1625 0.482283445153255 2284 997839
SGTC_2195 6536160 144.242 µM 0.0444159327713552 0.487681071884367 no 1626 0.482286430833419 2328 3834386
SGTC_2666 tannic acid 100 µM 0.0437255284556739 0.487967915896608 no 1627 0.482561594954357 2328 16134267 A thiamine antagonist.
SGTC_228 caffeine 993.056 µM 0.043293962644113 0.48814722279729 no 1628 0.482733601911941 2334 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2345 9052315 157.45 µM 0.0421554109325473 0.488620279499895 no 1629 0.483187403929705 2278 6469265
SGTC_2796 7949634 45.45 µM 0.0416027271950813 0.488849919807347 no 1630 0.483407699569279 2314 2971588
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0398409379481014 0.489581968225287 no 1631 0.48410996918136 2324 688664
SGTC_2157 5649910 96.377 µM 0.0398254455048316 0.489588405714462 no 1632 0.484116144870632 2323 2858091
SGTC_2284 7945075 39.21 µM 0.0390378892063345 0.489915658159429 no 1633 0.48443009020334 2323 1245402
SGTC_2844 9010103 25.97 µM 0.038962152098272 0.489947129482038 no 1634 0.48446028196834 2279 2480525
SGTC_1133 3473-0247 50 µM 0.0380947778123232 0.490307557163907 no 1635 0.484806057495877 2242 711311
SGTC_1726 st035556 14.5795 µM 0.0379436963913452 0.490370338175999 no 1636 0.48486628671716 2312 5919439
SGTC_629 3448-6466 76.7 µM 0.0379305656624645 0.490375794585855 no 1637 0.484871521351816 2333 573744
SGTC_1865 st057639 52.2 µM 0.0377440530132671 0.490453299194617 no 1638 0.484945875888966 2335 688818
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0376910728011476 0.490475314982366 no 1639 0.484966996906725 2344 97141
SGTC_1491 4138-0063 26.5 µM 0.0368457548614317 0.490826588507938 no 1640 0.485303995847193 2353 23883227
SGTC_2958 9077254 16.72 µM 0.0359498523388709 0.491198890316249 no 1641 0.485661172558374 2295 16457351
SGTC_2307 7538926 6.34 µM 0.035878510999431 0.491228537301417 no 1642 0.485689615285975 2285 96582
SGTC_833 3852-0053 558 µM 0.0352458454687032 0.491491453244347 no 1643 0.485941852762494 2314 3123681
SGTC_2884 9058502 51.95 µM 0.0342973625422063 0.491885619876887 no 1644 0.486320014010172 2307 6471554
SGTC_226 1,3-diallylurea 8.28947 mM 0.034135295511088 0.491952971830199 no 1645 0.486384631564267 2307 74537 YKL182W FAS1
SGTC_2229 7354935 190 µM 0.0340243720192905 0.491999069640722 no 1646 0.486428857944519 2344 318112
SGTC_1255 0566-0045 221 µM 0.0335310164063127 0.492204100656646 no 1647 0.486625566108421 2305 2788469
SGTC_690 glyoxal 20.3 µM 0.0327660182667497 0.492522026188135 no 1648 0.486930588574209 2322 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2526 patulin 37.61 µM 0.0327531083209755 0.492527391473061 no 1649 0.486935736134523 2300 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1932 st074806 40.9 µM 0.0322811145276946 0.492723549776896 no 1650 0.487123934889541 2300 17251235
SGTC_2595 hexamethylquercetagetin 100 µM 0.0317676337508745 0.492936951864274 no 1651 0.487328679063644 2317 386331
SGTC_2069 5228469 200 µM 0.0314388189213178 0.493073608037772 no 1652 0.487459791709346 2308 2835210
SGTC_2414 st077232 92.9 µM 0.030726415104264 0.493369687413578 no 1653 0.487743862449033 2305 729801
SGTC_269 exalamide 29 µM 0.0306597506566198 0.493397393754443 no 1654 0.487770445191504 2299 3316 A derivative of salicylamide.
SGTC_553 k007-0256 45.7 µM 0.0299061354372248 0.493710605165315 no 1655 0.488070956334101 2320 6287000
SGTC_769 0302-0231 76 µM 0.0293146553332615 0.493956434027456 no 1656 0.488306819330034 2335 571869 YER009W NTF2
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0290187276276358 0.49407942731771 no 1657 0.488424827198239 2346 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_612 0302-0167 22.4 µM 0.0284373190691487 0.494321073611924 no 1658 0.488656679957437 2332 235821
SGTC_386 1509-0011 3.07 µM 0.0276501914158153 0.494648224629035 no 1659 0.488970574994331 2352 3107280
SGTC_1247 0448-0043 5.84 µM 0.027318159334583 0.4947862270131 no 1660 0.489102986609395 2323 3089013 YGL099W LSG1
SGTC_289 k017-0060 526 µM 0.0270251848231958 0.494907996431051 no 1661 0.489219823390404 2357 5512909
SGTC_1054 3429-0080 167 µM 0.0269983880523422 0.494919134035353 no 1662 0.489230509855946 2356 1162877
SGTC_2897 9048598 12.99 µM 0.0267888441510621 0.495006227391139 no 1663 0.489314075552011 2344 6467404
SGTC_1421 4029-0249 71.4 µM 0.0257868432308042 0.495422695236037 no 1664 0.489713677970765 2355 2894095
SGTC_1071 trifluoperazine 6.31 µM 0.0252490798498843 0.495646211244917 no 1665 0.48992814467956 2339 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_574 1315-0397 40 µM 0.0225080663508829 0.496785506034405 no 1666 0.491021338806776 2364 6794277
SGTC_692 k241-0027 77.8 µM 0.0223937842636447 0.496833007706253 no 1667 0.491066919274513 2358 3600480
SGTC_1240 0356-0016 42.1 µM 0.0220592660824662 0.49697205138723 no 1668 0.491200339759767 2342 4305613
SGTC_1227 3909-8010 46.6 µM 0.021360586401687 0.497262461267389 no 1669 0.491479006940649 2340 15982272
SGTC_2705 st078069 42.8 µM 0.0204841127389901 0.497626774183215 no 1670 0.491828592808114 2345 1530061
SGTC_2605 digitonin 300 nM 0.0188701923410685 0.498297617374181 no 1671 0.49247232918588 2366 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2916 7875993 68.79 µM 0.0188367950413801 0.498311499374634 no 1672 0.492485650413023 2372 1299250
SGTC_2161 5662504 8.5105 µM 0.0185019925743591 0.498450664268861 no 1673 0.49261919399699 2350 2859334
SGTC_3289 9119912 71.43 µM 0.0182172442892135 0.498569023656205 no 1674 0.492732772982858 2359 17014829
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0163949328043939 0.499326494043048 no 1675 0.493459661121746 2367 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1526 st051518 75 µM 0.0157806275376786 0.499581839683401 no 1676 0.493704701749508 2315 673993
SGTC_2403 6032726 181.2 µM 0.015417265060353 0.49973287709612 no 1677 0.493849644768671 2366 2881040
SGTC_971 1315-0384 26.7 µM 0.0151257673078694 0.499854042817756 no 1678 0.493965921986536 2366 6769120
SGTC_3228 9131799 49.47 µM 0.0144234864137004 0.499854042817756 no 1679 0.494246060944803 2352 17015818
SGTC_2320 7373003 200 µM 0.0142864885729318 0.499797097462996 no 1680 0.494300709544876 2377 5415828
SGTC_1807 st050092 58.9 µM 0.0132920021027855 0.499383723371774 no 1681 0.494697414511573 2371 5008496
SGTC_353 1988-1175 58.3 µM 0.0121168542984191 0.498895255416075 no 1682 0.495166192796965 2345 2788357
SGTC_2376 9072922 81.32 µM 0.011893210034934 0.498802294461169 no 1683 0.495255407520172 2360 17087968
SGTC_2285 7945142 200 µM 0.0116312873927062 0.49869342263061 no 1684 0.495359892308041 2371 2970608
SGTC_2267 7931562 200 µM 0.0109295434430818 0.498401733388883 no 1685 0.49563982982254 2377 934880
SGTC_2853 9015042 58.44 µM 0.0106696183301687 0.498293692253954 no 1686 0.495743518892673 2374 6457456
SGTC_102 gallobenzophenone 83.616 µM 0.00987752287356437 0.49796444864271 no 1687 0.49605950257628 2389 70837
SGTC_1523 st012844 44.7 µM 0.00806797134222551 0.497212293242186 no 1688 0.496781380032379 2365 4274103
SGTC_2565 isoliquiritigenin 100 µM 0.00793390619794191 0.497156568292391 no 1689 0.496834862574851 2359 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1901 st060216 58.6 µM 0.00788352262180097 0.497135626082908 no 1690 0.49685496208501 2388 688792
SGTC_1856 st057054 55.7 µM 0.00783741723443253 0.497116462132945 no 1691 0.496873354905157 2394 1266018
SGTC_266 formosanin C 406 nM 0.00758436627959156 0.497011280274677 no 1692 0.496974304628698 2390 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1572 epiandrosterone 68.9 µM 0.00740167139455257 0.496935342387214 no 1693 0.497047187296612 2377 441302 A steroid.
SGTC_2572 astragaloside iv 100 µM 0.00723463760677496 0.496865914196953 no 1694 0.497113822352378 2376 45006101 An anti-inflammatory agent.
SGTC_2198 6589944 200 µM 0.00696891814118472 0.496755467148835 no 1695 0.497219826408411 2382 5290268
SGTC_3047 9092122 49.47 µM 0.00650366476437729 0.496562083869673 no 1696 0.49740543143864 2390 17173831
SGTC_2047 4141938 200 µM 0.00641844932369308 0.496526664027336 no 1697 0.497439426771283 2391 3807862
SGTC_1146 3579-1023 7 µM 0.00531254005276943 0.496066994846984 no 1698 0.4978806131259 2395 X1146
SGTC_802 4112-3352 742 µM 0.00525414478644289 0.496042723100356 no 1699 0.497903909141469 2387 704594
SGTC_85 0868-0259 160.055 µM 0.00523824358398645 0.496036113835026 no 1700 0.497910252716141 2377 83173
SGTC_1539 benzyladenosine 56 µM 0.00465845827075561 0.495795129360348 no 1701 0.498141550756086 2395 92208 A nucleotide analog.
SGTC_1249 0481-0015 10.2 µM 0.00326627426984156 0.495216482415625 no 1702 0.49869694741132 2401 4227577
SGTC_669 0108-0021 26.2 µM 0.00300771624403374 0.495109016506338 no 1703 0.498800096631931 2402 17201
SGTC_2108 5365811 200 µM 0.00287394661501508 0.49505341723079 no 1704 0.498853462761971 2393 780283
SGTC_1385 3091-4834 14.1 µM 0.00215817570297089 0.494755919790545 no 1705 0.499139013131923 2397 4072814
SGTC_2365 9042475 200 µM 0.00176703031882606 0.49459334839505 no 1706 0.499295057261921 2396 6464479
SGTC_1222 0366-0074 1.18 µM 0.000117396383642212 0.493907722760834 no 1707 0.499953165619106 2404 286520
SGTC_642 0335-0876 158 µM 0 0.493858930797871 no 1708 0.5 2405 6812350
SGTC_2551 apiole 73.87 µM -0.000452440120624372 0.493670889741761 no 1709 0.499819502512691 2406 10659 A possible DNA adduct former.
SGTC_571 k831-0106 44.2 µM -0.00131778483911049 0.493311243152039 no 1710 0.499474280063364 2409 4783639
SGTC_545 4218-0007 221 µM -0.00164486562291756 0.493175306253865 no 1711 0.499343793853343 2412 2840508
SGTC_1447 4239-0816 81.9 µM -0.00222717332725672 0.492933297361423 no 1712 0.499111487128524 2411 1341554
SGTC_50 0929-0078 56.389 µM -0.0024780922575662 0.492829015470494 no 1713 0.499011385235559 2421 1377751
SGTC_1497 4476-2978 41.3 µM -0.00360945048411566 0.492358829255951 no 1714 0.498560040719535 2435 1528379
SGTC_173 1273-0061 2.693 µM -0.00566763606472413 0.491503486406725 no 1715 0.497738952448792 2423 2847414 YPL266W DIM1
SGTC_130 0136-0219 337.655 µM -0.00768391732844115 0.490665596052341 no 1716 0.496934590663554 2419 234244
SGTC_2659 sanguinarine 24.21 µM -0.00824677047631728 0.49043170273385 no 1717 0.496710051871409 2420 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3322 9139058 2.11 µM -0.00859016861106517 0.490289005437176 no 1718 0.496573060691532 2485 4908926 YPR165W RHO1
SGTC_3244 9134489 49.47 µM -0.0098276352560307 0.489774793094014 no 1719 0.496079403890214 2446 16584271
SGTC_1883 5-benzylidenerhodanine 20 µM -0.00994759412084441 0.489724946717965 no 1720 0.496031549566454 2422 1273210
SGTC_760 0568-0725 82.9 µM -0.0107340621734687 0.489398150517954 no 1721 0.495717810991071 2428 3916171
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0110089330554968 0.489283936789584 no 1722 0.49560815985492 2424 803109
SGTC_2247 cerulenin 830 nM -0.0111338814017041 0.489232018824793 no 1723 0.495558315731726 2441 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1418 3966-3099 2.4 µM -0.0118116304604973 0.488950406840259 no 1724 0.495287950775707 2426 740335
SGTC_2972 9093619 59.92 µM -0.0125363470095076 0.488649285459117 no 1725 0.494998852133197 2432 25236256
SGTC_1301 naphtanilide LB 4.81 µM -0.0132885987095843 0.48833673000564 no 1726 0.494698772149111 2429 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1531 st059297 52.4 µM -0.0133643638458293 0.488305250501863 no 1727 0.494668548916758 2446 7566702
SGTC_2842 9000675 19.48 µM -0.0134256118963078 0.488279802726042 no 1728 0.494644116671818 2440 2989072
SGTC_1307 1187-1599 12.2 µM -0.0145693972979699 0.487804583506689 no 1729 0.494187857039953 2437 1538471
SGTC_413 propylparaben 100 µM -0.0154951288194907 0.487419973819241 no 1730 0.493818585333226 2433 7175 A pharmaceutical preservative.
SGTC_493 zm226600 134 µM -0.0156754886608043 0.487345041843526 no 1731 0.493746640905185 2438 5240098 A potassium channel opener. YCR052W RSC6
SGTC_218 alverine citrate 93.75 µM -0.0164166719726914 0.487037115875071 no 1732 0.49345098961542 2437 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1702 st027038 51 µM -0.0165059490783384 0.487000026055393 no 1733 0.493415378028564 2452 5521182
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0171936610014491 0.486714322655991 no 1734 0.493141059615552 2456 6708739 YPR165W RHO1
SGTC_1129 3453-1384 223 µM -0.017970377759506 0.486391651248826 no 1735 0.492831242358857 2505 1084452
SGTC_3112 9123419 49.47 µM -0.0186162813828358 0.486123330311927 no 1736 0.492573607210805 2436 17015854
SGTC_1025 k007-0731 70 µM -0.0199608584575749 0.485564787115634 no 1737 0.492037298382667 2450 6256118
SGTC_2881 9058953 51.95 µM -0.0199714130282396 0.485560402811415 no 1738 0.492033088557378 2438 17122249
SGTC_710 3448-4187 58 µM -0.02019270072184 0.485468481657197 no 1739 0.491944825340035 2452 3946412
SGTC_2834 9001755 58.44 µM -0.0206638102727371 0.485272789061197 no 1740 0.49175691903524 2515 2989575
SGTC_2194 5927483 104.545 µM -0.0218097574742102 0.484796792846274 no 1741 0.491299855350177 2436 760979
SGTC_2250 alverine citrate 130 µM -0.0221882842756628 0.484639567532392 no 1742 0.491148881542543 2437 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_961 1252-1571 372 µM -0.0222833744969706 0.484600071126503 no 1743 0.491110955409933 2450 6813498
SGTC_2084 5306078 60.6385 µM -0.0229515308749367 0.484322551862188 no 1744 0.490844467755284 2472 679340
SGTC_944 3370-0224 231 µM -0.0234882832574395 0.48409961684256 no 1745 0.490630392257057 2456 4580514
SGTC_1331 1472-0049 76.2 µM -0.0236208871866725 0.484044541819122 no 1746 0.490577505616455 2448 24051409
SGTC_1944 st076371 56.9 µM -0.0238002363653061 0.483970052352414 no 1747 0.490505975755778 2455 24208455
SGTC_3295 9122362 53.5725 µM -0.0248298508428752 0.483542431338203 no 1748 0.490095340432422 2461 4730473
SGTC_1185 1319-0113 81.3 µM -0.0251291048317061 0.483418148255686 no 1749 0.489975992604943 2480 4672763
SGTC_1717 st033143 58.0435 µM -0.0254484449102249 0.483285525002679 no 1750 0.489848635076826 2459 674616
SGTC_2318 6029776 164 µM -0.0256661735209376 0.483195102471151 no 1751 0.489761802291711 2467 818325
SGTC_1990 st072050 59.8 µM -0.0258298407739532 0.483127132150426 no 1752 0.489696530144632 2452 17233948
SGTC_2164 5685496 200 µM -0.0259882349814334 0.483061352170204 no 1753 0.48963336120389 2453 759046
SGTC_2749 bexarotene 57.39 µM -0.0261810279739656 0.482981287243166 no 1754 0.489556474089676 2480 82146 An retinoic acid receptor inhibitor.
SGTC_633 0437-0093 97.7 µM -0.0266560184629503 0.482784031562422 no 1755 0.489367046418567 2448 2831118
SGTC_103 0844-0104 51.839 µM -0.0285802904089277 0.481984956921763 no 1756 0.488599665819047 2499 5375804
SGTC_1942 st076330 65.2 µM -0.0287079521446561 0.481931946536197 no 1757 0.488548757044355 2522 24208414
SGTC_2655 perillic acid 100 µM -0.0288277593734655 0.481882197954419 no 1758 0.488500980649026 2461 5702197 An apoptosis inducer.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0291861396190602 0.481733386342724 no 1759 0.488358067753689 2466 551469
SGTC_1355 1499-0035 1.68 µM -0.0298362302393563 0.481463453217089 no 1760 0.488098832033801 2467 1548538
SGTC_1911 st060208 74.3 µM -0.0302648404791565 0.481285488667071 no 1761 0.487927918476498 2490 688783
SGTC_112 phenothiazine 287.218 µM -0.0324962182533672 0.480359052624617 no 1762 0.487038165917592 2467 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3135 9127742 49.47 µM -0.0332146678030356 0.48006078501336 no 1763 0.486751700680552 2517 3643468
SGTC_2174 5790901 200 µM -0.0335554744262949 0.479919301481107 no 1764 0.486615814257843 2488 786020
SGTC_1076 itraconazole 331 nM -0.0336561849178464 0.479877492694707 no 1765 0.486575659265659 2464 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2561 acetosyringone 100 µM -0.0356329602661616 0.479056902850489 no 1766 0.485787513255271 2452 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1720 st037298 9.481 µM -0.0360459283821889 0.478885484528188 no 1767 0.485622868588681 2498 597396
SGTC_1006 4099-6547 255 µM -0.0363476453793063 0.478760247734949 no 1768 0.48550257974975 2513 3146833
SGTC_393 acivicin 6.25 µM -0.0366098914013304 0.47865139627045 no 1769 0.485398028310473 2489 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1205 4161-2785 76 µM -0.0369010025799348 0.478530565499703 no 1770 0.48528197017504 2570 3498106
SGTC_3083 9117465 49.47 µM -0.0372063222288024 0.478403839375908 no 1771 0.485160248847332 2539 16420915
SGTC_1642 st009582 77.7 µM -0.0378234106788895 0.478147717019198 no 1772 0.484914239351271 2476 6739311
SGTC_187 1488-2104 32.728 µM -0.0384546080576307 0.477885748093575 no 1773 0.484662611107565 2528 2852859
SGTC_2111 5486399 200 µM -0.0406967674824632 0.476955251766482 no 1774 0.483768819318835 2469 689674
SGTC_1003 4049-0218 100 µM -0.0408329749688512 0.476898729646193 no 1775 0.483714525524424 2522 295161
SGTC_286 k060-0067 22.9 µM -0.0438565544752582 0.475644154375285 no 1776 0.482509373230995 2496 5985051
SGTC_1945 st075991 56.6 µM -0.0438855424531648 0.4756321275285 no 1777 0.482497819824577 2514 1084980
SGTC_2063 5246145 200 µM -0.04429251342125 0.475463281346587 no 1778 0.482335619622079 2532 711240
SGTC_1824 st053723 68.6 µM -0.0447914071173101 0.475256303811039 no 1779 0.482136787173637 2504 675225
SGTC_2323 6148992 148.28 µM -0.044923540865599 0.475201486199665 no 1780 0.482084126443252 2525 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_848 0368-0089 85.6 µM -0.045747373414667 0.474859717887083 no 1781 0.481755802392972 2492 762535
SGTC_1269 0831-0796 3.05 µM -0.0472075994741716 0.474253986272467 no 1782 0.481173885386056 2517 927758
SGTC_1637 st007924 17.4 µM -0.0501840840722566 0.473019465415357 no 1783 0.479987847321319 2498 683336
SGTC_3029 9088683 49.47 µM -0.0504854592632879 0.472894481885793 no 1784 0.479867768227747 2577 25236615
SGTC_1186 1319-0216 26 µM -0.0526005327702838 0.472017413952342 no 1785 0.479025096235383 2550 4565136
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.053863059490815 0.471493940180305 no 1786 0.47852213408767 2664 5282309
SGTC_2428 5615643 7.78 µM -0.0544350538581946 0.471256793790866 no 1787 0.47829427565264 2547 2253075
SGTC_168 3970-0862 530.542 µM -0.0555059530906438 0.470812831070673 no 1788 0.477867693691609 2551 3135186
SGTC_1937 st074714 47.2 µM -0.0558364728470679 0.470675814787038 no 1789 0.477736039561786 2505 17250970
SGTC_885 0865-0106 16.8 µM -0.0573785500070463 0.470036596021323 no 1790 0.477121824730756 2508 2793380
SGTC_1649 st011737 51.3 µM -0.0574037181808356 0.470026163995706 no 1791 0.477111800604157 2538 1761035
SGTC_2134 5324836 1.464 µM -0.0578385745908026 0.469845922420283 no 1792 0.476938605756932 2534 699272
SGTC_3207 9114163 49.47 µM -0.058030427471722 0.469766404189652 no 1793 0.47686219587021 2535 849233
SGTC_853 0419-0306 21 µM -0.058484464724593 0.469578221889883 no 1794 0.476681368333227 2506 762713
SGTC_1410 3909-8106 77.9 µM -0.0590955838810177 0.469324945461171 no 1795 0.476437988024437 2545 1039210
SGTC_1499 4480-0877 67.3 µM -0.0595156943118332 0.469150839196212 no 1796 0.476270682690947 2509 2861909
SGTC_1797 st048695 56.8 µM -0.0597478027492842 0.469054649079972 no 1797 0.476178249312029 2501 592262 YIL048W NEO1
SGTC_1155 4088-0394 48.2 µM -0.059897032084496 0.468992806581182 no 1798 0.476118821853152 2507 2326248
SGTC_231 b-estradiol 524 µM -0.0604177712755531 0.468777011631634 no 1799 0.475911452540547 2507 450 A steroid.
SGTC_3290 9121031 71.43 µM -0.0611011573577074 0.468493829541543 no 1800 0.475639323718393 2542 17014854
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0611222467340296 0.46848509076115 no 1801 0.475630925970444 2501 66535 A nucleotide analog.
SGTC_830 4076-0286 57.8 µM -0.0623060613177914 0.467994579358661 no 1802 0.475159550811934 2543 6866659
SGTC_468 gf-109203x 121 µM -0.0636764346511679 0.467426828405389 no 1803 0.474613934541091 2516 2396 A protein kinase C inhibitor.
SGTC_2544 sphondin 68.51 µM -0.0640438195727898 0.46727463063152 no 1804 0.474467667714304 2636 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_551 k048-0028 34.9 µM -0.0651713346948938 0.46680756115891 no 1805 0.474018792096947 2559 6836383
SGTC_1389 3405-0187 19 µM -0.0656924110736847 0.466591722366227 no 1806 0.47381135722466 2565 799890
SGTC_1713 st033146 12.748 µM -0.0678347967210124 0.465704413328036 no 1807 0.47295857188488 2547 674619
SGTC_252 miconazole 1.30953 nM -0.0682484621324204 0.465533105568823 no 1808 0.472793924835172 2532 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2811 7967822 32.47 µM -0.068277927052932 0.465520903753715 no 1809 0.4727821973886 2593 2232244
SGTC_1386 3228-0095 33.8 µM -0.0689520280321482 0.465241758457659 no 1810 0.472513902324353 2579 870181
SGTC_846 0335-0850 148 µM -0.0691684441270016 0.465152144147183 no 1811 0.472427770434327 2538 6819598
SGTC_2470 5664817 21.68 µM -0.0695430770773321 0.464997019044943 no 1812 0.472278672540207 2527 2859561
SGTC_1341 1486-1360 280 µM -0.0695882334111787 0.464978321419729 no 1813 0.472260701306879 2523 3976547
SGTC_535 2293-4129 48.2 µM -0.0698781954717669 0.464858260329845 no 1814 0.472145304095198 2522 396118 YIL048W NEO1
SGTC_2348 9022543 33.42 µM -0.0734465137010172 0.463381035167889 no 1815 0.470725402467416 2611 3162678 YDL140C RPO21
SGTC_1279 0874-0590 65.2 µM -0.0738377560019871 0.463219097618543 no 1816 0.470569742031484 2599 3523074
SGTC_1251 0490-5699 265 µM -0.0751146616819304 0.46269062119745 no 1817 0.470061741223019 2551 3883818
SGTC_2657 nystatin 74.44 µM -0.075278397094739 0.462622860321101 no 1818 0.469996604662628 2578 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1265 0819-1001 68.8 µM -0.075330739396334 0.462601199015707 no 1819 0.469975782228949 2521 3106768
SGTC_1630 st005209 31.3 µM -0.0760622417968491 0.462298486153698 no 1820 0.469684789882091 2521 3367314
SGTC_40 0327-0103 19.753 µM -0.0769841653243516 0.461917003683043 no 1821 0.469318070910626 2571 409036
SGTC_469 w7 172 µM -0.0785356867313277 0.461275079353824 no 1822 0.468700971984306 2532 45115570 A P450 inhibitor.
SGTC_1125 tnp00248 1.32998 µM -0.0785864633492568 0.461254072801607 no 1823 0.468680777459528 2618 24207736
SGTC_2982 9019404 25.97 µM -0.0797889072867979 0.460756647181573 no 1824 0.468202573449108 2570 22333232
SGTC_2103 5378138 10 µM -0.0803926624003956 0.460506909568724 no 1825 0.46796248128675 2548 244142
SGTC_341 1486-1430 230 µM -0.0806963974977196 0.46038127829147 no 1826 0.467841700927478 2545 2054753 YPL210C SRP72
SGTC_1192 1488-0095 21.4 µM -0.0823689911616262 0.459689529271003 no 1827 0.467176646852137 2631 915875
SGTC_1254 0550-0035 264 µM -0.0844107335333944 0.458845273805002 no 1828 0.466364936809661 2633 15121435
SGTC_2327 6189656 200 µM -0.0854843799115868 0.45840139787324 no 1829 0.465938156518815 2629 5349088
SGTC_3038 9091290 49.47 µM -0.087526376927415 0.45755732185083 no 1830 0.465126560062672 2606 25236843
SGTC_65 0798-0905 34.986 µM -0.0890181138274679 0.456940821076588 no 1831 0.46453375725817 2710 3602145
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.089026608482531 0.456937310725056 no 1832 0.46453038178293 2602 1273210
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.08938290566101 0.456790076658283 no 1833 0.464388804197912 2528 2333 A French combination drug.
SGTC_1488 4013-0813 75.9 µM -0.0900148572345804 0.456528947458413 no 1834 0.464137704196261 2549 2910057
SGTC_1678 st019265 80.2 µM -0.0907030418381863 0.456244603520259 no 1835 0.463864276779923 2586 5367020
SGTC_3014 9081533 49.47 µM -0.0907227446405443 0.456236463050665 no 1836 0.463856448773034 2612 21367265
SGTC_2855 9016525 58.44 µM -0.091671759955839 0.455844386817762 no 1837 0.463479417590244 2567 43811474
SGTC_1875 nocodazole 6 µM -0.0919314850600902 0.455737091453352 no 1838 0.463376237957607 2549 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2651 TUB2.036 5 µM -0.0927377770837606 0.455404023742045 no 1839 0.463055942271888 2631 15992207 YFL037W TUB2
SGTC_3 0833-0587 95.581 µM -0.0928138164398595 0.455372614584482 no 1840 0.463025737230555 2534 5382644
SGTC_2704 st078022 71.1 µM -0.0928470593908484 0.455358883189632 no 1841 0.463012532231609 2642 54697681
SGTC_3249 9135183 49.47 µM -0.0942585401357895 0.454775903754031 no 1842 0.462451891705127 2727 4902779
SGTC_1561 5-methoxyflavone 52.9 µM -0.0945417530831672 0.454658940895867 no 1843 0.462339408395861 2557 94525
SGTC_826 1683-5028 118 µM -0.0945426334694708 0.454658577315159 no 1844 0.462339058738696 2639 722377
SGTC_3151 9099821 49.47 µM -0.0946156636393764 0.454628417549696 no 1845 0.462310053933837 2675 17174189
SGTC_1897 st060201 15 µM -0.0955924089511633 0.454225069613341 no 1846 0.461922147185011 2602 611878
SGTC_3187 9109394 49.47 µM -0.0960507952881687 0.454035794773152 no 1847 0.461740115106423 2619 17098090
SGTC_1027 k015-0025 8.67 µM -0.0961025251591395 0.454014435360393 no 1848 0.461719572902576 2563 3598955
SGTC_1829 berberine 14.4 µM -0.0981686061981722 0.453161453929728 no 1849 0.460899205324675 2744 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3306 9127676 59.7925 µM -0.0987789824590413 0.452909501294864 no 1850 0.460656878217634 2642 41905287
SGTC_1313 1220-0047 237 µM -0.10007658611701 0.452373936335216 no 1851 0.460141761785167 2630 3528706
SGTC_3031 9088762 49.47 µM -0.100387074871634 0.452245799924356 no 1852 0.460018515344119 2576 205253
SGTC_3293 9120939 62.045 µM -0.100763232514533 0.452090569113602 no 1853 0.459869207222845 2671 934087
SGTC_1304 1165-0502 251 µM -0.102188794553556 0.451502342137566 no 1854 0.459303410922173 2619 767425
SGTC_1376 2910-0861 41.3 µM -0.103560462427652 0.450936453898527 no 1855 0.458759082653815 2599 1112859
SGTC_887 0885-0007 9.62 µM -0.103734410314504 0.450864697953739 no 1856 0.458690059236836 2745 5719458
SGTC_3124 9127567 49.47 µM -0.103788178530251 0.450842518134862 no 1857 0.458668723983927 2632 17592030
SGTC_2525 harmine 47.85 µM -0.104662616421628 0.45048182710967 no 1858 0.458321763380534 2672 5280953 A monoamine oxidase inhibitor
SGTC_2259 7964009 200 µM -0.105582124428414 0.450102589528923 no 1859 0.457956954052792 2769 313134
SGTC_2398 5228213 48.84 µM -0.106700834202496 0.449641255570312 no 1860 0.457513160394321 2623 80771 YMR134W ERG29
SGTC_1177 0983-0204 23.6 µM -0.108910125496305 0.448730387689689 no 1861 0.456636887718219 2663 766818
SGTC_960 1222-0186 7.7 µM -0.108942875158597 0.44871688736405 no 1862 0.456623899773137 2707 3126296
SGTC_1388 3346-4487 254 µM -0.110055629472266 0.44825821433883 no 1863 0.456182628438661 2671 3345614
SGTC_3072 9116419 49.47 µM -0.110113346667978 0.448234425415388 no 1864 0.45615974170749 2659 17170162
SGTC_2265 7929201 200 µM -0.110499606530161 0.44807522798057 no 1865 0.456006580951536 2576 1265108
SGTC_3353 9151644 39.2805 µM -0.111505419773588 0.447660720229006 no 1866 0.455607784022755 2695 4909158
SGTC_141 0443-0274 32.331 µM -0.11207008180063 0.447428041226583 no 1867 0.455383919608967 2637 1627241
SGTC_496 calpeptin 138 µM -0.112562258309931 0.447225245921319 no 1868 0.455188804164421 2683 73364 A calpain inhibitor.
SGTC_24 0417-1663 219 µM -0.112925984429015 0.447075385889611 no 1869 0.455044617749962 2663 4329390
SGTC_2770 toltrazuril 17.5 µM -0.114089928930901 0.446595876052872 no 1870 0.454583252821682 2601 68591 Kills coccidiodes.
SGTC_607 4491-0986 66.8 µM -0.114683692183225 0.446351293627967 no 1871 0.454347920192685 2686 698981 YDR232W HEM1
SGTC_2380 9035439 200 µM -0.115776286468671 0.445901286569743 no 1872 0.45391492238357 2736 6462575
SGTC_588 3970-1144 52.9 µM -0.117701426145463 0.445108548750999 no 1873 0.453152118368237 2746 1888707
SGTC_2181 6316240 54.2555 µM -0.119501229003709 0.444367620798753 no 1874 0.452439133205222 2694 12779990
SGTC_41 0478-0632 82.643 µM -0.119917405320737 0.444196320349871 no 1875 0.452274288259556 2614 3750424
SGTC_3034 9090421 49.47 µM -0.120631373943144 0.443902471257247 no 1876 0.451991508744109 2596 17173761
SGTC_1319 1306-0155 43.7 µM -0.120990597904027 0.443754636586293 no 1877 0.451849241135061 2619 3122360
SGTC_1830 st055982 50.3 µM -0.122255063885156 0.443234321915906 no 1878 0.451348509395657 2610 455313 An antimicrobial agent.
SGTC_1587 estradiol valerate 56.1 µM -0.122411541821742 0.443169939650381 no 1879 0.451286549101253 2643 13791 A steroid.
SGTC_3042 9091578 49.47 µM -0.12248707977368 0.443138860377615 no 1880 0.451256638895421 2603 25236497
SGTC_2342 7990637 118.86 µM -0.12263681930013 0.443077252704354 no 1881 0.451197348457459 2714 2033102 YER133W GLC7
SGTC_2231 micatex 6.853 µM -0.123581970991477 0.442688418614763 no 1882 0.450823134054498 2652 20737 An antifungal of unknown mechanism.
SGTC_2786 7743617 45.45 µM -0.124185969192912 0.442439963479364 no 1883 0.450584015600403 2661 583674
SGTC_1814 st052110 31.539 µM -0.125153846080374 0.44204187380261 no 1884 0.450200877679081 2671 674163
SGTC_1508 1080-0625 72.9 µM -0.125269463813409 0.441994323905866 no 1885 0.450155113034922 2596 767111
SGTC_637 1181-0519 7.26 µM -0.125424629971155 0.441930510313416 no 1886 0.450093695090128 2628 6252091 YGR060W ERG25
SGTC_2624 nerol 100 µM -0.125841223642476 0.441759189570892 no 1887 0.44992880469504 2596 637566 A natural product oil.
SGTC_177 1327-0068 8.361 µM -0.126002019386268 0.441693066547779 no 1888 0.449865163038958 2619 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_126 0417-1624 672.48 µM -0.129824640857352 0.440121596478515 no 1889 0.448352583656029 2627 41912 YDL195W SEC31
SGTC_1378 2093-0007 380 nM -0.130405809390629 0.439882761509686 no 1890 0.448122685305656 2719 3618014
SGTC_2104 5389443 200 µM -0.130521446700878 0.43983524221551 no 1891 0.448076943633567 2775 2244536
SGTC_1861 st057647 17.4 µM -0.131259978601731 0.439531774873144 no 1892 0.447784825130317 2839 688668
SGTC_1191 1487-1166 10.6 µM -0.131349334573734 0.43949506035549 no 1893 0.447749483235306 2756 3955771
SGTC_9 0092-0002 10.449 µM -0.131453167766939 0.439452398101317 no 1894 0.447708415859842 2659 759368
SGTC_2848 9016370 25.97 µM -0.135858015913121 0.437643218858045 no 1895 0.445966763055514 2656 7894410
SGTC_1480 1070-0044 41.2 µM -0.136605961989641 0.437336147405534 no 1896 0.445671131849562 2742 3124987
SGTC_1012 4112-3522 18 µM -0.136613800269375 0.437332929576348 no 1897 0.445668033871299 2649 3112398
SGTC_2827 7993847 71.43 µM -0.137062984624716 0.437148533989001 no 1898 0.445490505136828 2730 2985692
SGTC_621 3584-0052 32.1 µM -0.137258092343178 0.437068444171502 no 1899 0.445413397157612 2655 2273927
SGTC_2221 6807166 181.081 µM -0.137730655721984 0.43687447220297 no 1900 0.445226645261121 2662 674925
SGTC_1708 st033234 31.827 µM -0.13806832238036 0.436735880264149 no 1901 0.445093210521221 2753 674664
SGTC_2761 levamisole 97.89 µM -0.138451746237107 0.436578517151292 no 1902 0.444941701586981 2724 26879 An alkaline phosphatase inhibitor.
SGTC_2485 5633444 17.78 µM -0.138533233180488 0.436545074934944 no 1903 0.444909503269947 2735 5724239
SGTC_221 trifluoperazine 10.304 µM -0.138697148619755 0.436477805463377 no 1904 0.444844735696992 2656 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1384 3089-0840 101 µM -0.139894142964818 0.435986625200374 no 1905 0.444371814509924 2690 1069836
SGTC_58 0957-0393 9 µM -0.141415494669491 0.43536248917316 no 1906 0.44377085715131 2649 6997992
SGTC_3292 9120825 59.784 µM -0.141475715008299 0.43533778702233 no 1907 0.443747071840761 2673 24824900
SGTC_316 k060-0003 58.6 µM -0.14200332167205 0.435121375602941 no 1908 0.443538690981194 2797 6152314
SGTC_2211 7117706 200 µM -0.14333761865574 0.43457416629486 no 1909 0.443011773586077 2668 822771
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.143678895458274 0.434434225151453 no 1910 0.442877018623416 2711 688662
SGTC_274 sirtinol 40.1 µM -0.144168637353005 0.434233419997529 no 1911 0.442683652976792 2704 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_94 0334-0113 514.748 µM -0.144324714412682 0.43416942846782 no 1912 0.442622031665599 2675 6795178
SGTC_465 cgp-37157 41 µM -0.144799224512442 0.433974890125056 no 1913 0.442434697261136 2722 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_139 0099-0334 718.624 µM -0.144959164103326 0.433909322133401 no 1914 0.442371556744705 2659 97690
SGTC_880 0833-0487 87.2 µM -0.146022769172584 0.433473338545938 no 1915 0.441951706941685 2669 76075
SGTC_472 calcifediol 10 µM -0.146936545691353 0.433098835973359 no 1916 0.441591052844198 2739 5283731 A vitamin D metabolite.
SGTC_1579 chlormadinone acetate 49.4 µM -0.147367443560532 0.432922257422467 no 1917 0.441421000600786 2812 45114258 A steroidal progestin.
SGTC_1039 k821-0043 94 µM -0.147961228879906 0.432678950828589 no 1918 0.441186683128932 2741 15992768
SGTC_1243 0416-0003 5.65 µM -0.149973007024116 0.43185480462086 no 1919 0.440392955822379 2744 2141977
SGTC_1060 3448-7350 82 µM -0.151813616515812 0.431101039090145 no 1920 0.439666971097624 2764 570178
SGTC_271 rotenone 740 µM -0.152394719965642 0.430863117855055 no 1921 0.439437810648402 2808 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1437 4092-1038 11.6 µM -0.152704079779706 0.430736466868283 no 1922 0.439315821651728 2696 3977136
SGTC_2405 ticlatone 3.52 µM -0.153978544441132 0.430214780092245 no 1923 0.438813326436608 2613 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_318 1488-0629 67.2 µM -0.156239031218987 0.429289777167465 no 1924 0.437922306013752 2761 3662576
SGTC_1273 0849-0096 14.1 µM -0.156335384984551 0.42925035729535 no 1925 0.437884333024533 2729 5286025
SGTC_2681 menadione 3.18 µM -0.157952866739448 0.428588725181843 no 1926 0.437246969631377 2730 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.158032530851572 0.42855614368705 no 1927 0.437215582442332 2663 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_237 nikkomycin 200 µM -0.158480248711174 0.42837304248095 no 1928 0.437039191609783 2820 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_31 0508-1974 57.237 µM -0.15910124357262 0.428119102472495 no 1929 0.436794554235814 2731 6810525
SGTC_3137 9097352 49.47 µM -0.16213513731739 0.426878898854698 no 1930 0.435599718339813 2988 44120435
SGTC_1806 st050005 60.3 µM -0.16252432493374 0.426719857674324 no 1931 0.435446487196583 2695 5194765
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.16263428064266 0.426674926526923 no 1932 0.435403197134742 2747 4330530
SGTC_1641 st009299 47.1 µM -0.163064850436865 0.426498992166421 no 1933 0.435233687307479 2694 4046054
SGTC_2766 oltipraz 83.91 µM -0.163317705270887 0.426395680414461 no 1934 0.435134147134312 2811 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1607 st000305 50.6 µM -0.163448617572146 0.426342194082561 no 1935 0.43508261311904 2852 5457690
SGTC_1489 4065-0444 182 µM -0.1639237800679 0.426148070171324 no 1936 0.434895573265692 2701 2877968
SGTC_3169 9102970 49.47 µM -0.164410893742206 0.425949082274269 no 1937 0.43470384415131 2683 17027839
SGTC_1216 1165-0504 9.65 µM -0.164447278218945 0.425934219825171 no 1938 0.434689523749434 2747 6304004
SGTC_360 0957-0399 1.01 µM -0.166195073450059 0.425220399056798 no 1939 0.434001718175422 2835 6752301 YPR165W RHO1
SGTC_2865 9030313 51.95 µM -0.166614867520296 0.425048986480564 no 1940 0.433836547318502 2688 42562754
SGTC_630 4356-0227 183 µM -0.166679222396277 0.425022710002692 no 1941 0.433811227471572 2710 779312
SGTC_2360 9040895 200 µM -0.166727986352153 0.425002799611871 no 1942 0.433792041912743 2760 4914414
SGTC_2366 9070441 60.58 µM -0.167204430128389 0.42480827703051 no 1943 0.433604599376854 2720 6837235
SGTC_349 k015-0014 24 µM -0.167353177751371 0.42474755006275 no 1944 0.433546082135717 2702 2196908
SGTC_2266 7929956 200 µM -0.168530221663676 0.424267079040496 no 1945 0.433083085115299 2681 2967153
SGTC_700 3453-2283 142 µM -0.168792895180958 0.424159870665217 no 1946 0.432979773482124 2880 565664
SGTC_874 0599-0792 117 µM -0.1707977957601 0.423341769834903 no 1947 0.432191381168011 2758 765305
SGTC_1679 SEC14.276 6.7 µM -0.172609854853785 0.422602642217649 no 1948 0.431479052561684 2874 1005053 YMR079W SEC14
SGTC_2486 5283202 22.39 µM -0.173756840714735 0.422134934451893 no 1949 0.43102828222986 2782 1377751
SGTC_3199 9111318 49.47 µM -0.174100694644697 0.421994742092732 no 1950 0.430893163645046 2835 8548020
SGTC_2390 9097792 176.6 µM -0.174570627897548 0.421803162040416 no 1951 0.430708514840727 2729 4497149
SGTC_2980 9014342 25.29 µM -0.174857862252864 0.421686072875598 no 1952 0.430595660566105 2888 2996599
SGTC_164 4100-3994 89.624 µM -0.175343576773738 0.421488090355949 no 1953 0.430404836406822 2728 4615967
SGTC_3020 9089140 49.47 µM -0.176966549175716 0.420826693384258 no 1954 0.42976733236292 2788 17217859
SGTC_113 0099-0221 2.5 µM -0.178507729316228 0.420198835327328 no 1955 0.429162125783971 2803 89219
SGTC_557 1315-0110 16.2 µM -0.179037269505975 0.419983153870521 no 1956 0.428954218814874 2730 6833801
SGTC_1683 st010134 710 nM -0.17922672078422 0.419905996291727 no 1957 0.42887984163192 2703 3818134
SGTC_2309 7664088 163.95 µM -0.179244535447648 0.419898741094937 no 1958 0.42887284785552 2804 704922
SGTC_2678 equilin 100 µM -0.179544356473752 0.419776640121437 no 1959 0.428755145856691 2816 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_661 1304-0007 33.6 µM -0.179592110289514 0.419757193274088 no 1960 0.428736399525444 2737 3117130
SGTC_93 0109-0045 59.227 µM -0.179919107248366 0.419624035152406 no 1961 0.428608037282011 2676 88733
SGTC_1515 3460-0031 42.1 µM -0.179947206711531 0.419612593053952 no 1962 0.428597007225375 2755 2876596
SGTC_482 fipronil 114 µM -0.17998428521334 0.419597494795917 no 1963 0.428582452656338 2699 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3104 9120930 49.47 µM -0.180421430298391 0.419419499519036 no 1964 0.428410865718125 2798 17014836
SGTC_955 1216-0110 33 µM -0.181072021128323 0.419154624655157 no 1965 0.42815552273342 2688 3619719
SGTC_1311 1190-0148 100 µM -0.181854145470021 0.418836247094203 no 1966 0.427848595483218 2845 1961333
SGTC_2043 5101342 149 µM -0.183144854681167 0.418310957381162 no 1967 0.427342180991126 2748 678451
SGTC_2314 7727897 200 µM -0.18429260916316 0.417843969359612 no 1968 0.426891955830004 2752 900724
SGTC_3120 9124077 49.47 µM -0.184339714360562 0.417824806090318 no 1969 0.426873480088785 2692 18774327 YGL155W CDC43
SGTC_3144 9087057 49.47 µM -0.184568191420262 0.417731860147651 no 1970 0.426783868410953 2697 17249618
SGTC_1764 st044502 93.5 µM -0.186331776413555 0.417014577406392 no 1971 0.426092294909862 2851 8407
SGTC_1729 st035615 45.989 µM -0.186793713846127 0.416826744421082 no 1972 0.425911187897721 2862 17385451
SGTC_2839 9003951 25.97 µM -0.187338522216355 0.416605238860834 no 1973 0.425697610623533 2693 2990634
SGTC_2701 st077767 14.721 µM -0.187619670403061 0.416490941339569 no 1974 0.425587402661705 2762 5721188
SGTC_210 3551-0445 56.827 µM -0.189275711403199 0.415817840740293 no 1975 0.424938365364582 2879 2865180 YOR207C RET1
SGTC_273 hydroxyurea 18.1 mM -0.190085946768269 0.415488609060672 no 1976 0.424620891083183 2736 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_623 k072-0108 16.9 µM -0.191028324958455 0.415105756997045 no 1977 0.42425170083463 2832 5382803
SGTC_2616 abietic acid 100 µM -0.191116737219806 0.41506984262111 no 1978 0.424217067460981 2808 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_867 0518-0118 155 µM -0.19126420202114 0.415009941804085 no 1979 0.424159302979453 2760 6848158
SGTC_208 k072-0098 12.366 µM -0.192136993861615 0.414655450617943 no 1980 0.423817448905248 2747 5948901
SGTC_989 1501-0895 10.3 µM -0.192561739818773 0.414482961868271 no 1981 0.423651105632312 2761 2830112
SGTC_2417 cerulenin 830 nM -0.195060721132346 0.413468463957846 no 1982 0.42267270593688 2718 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2256 7954252 200 µM -0.195643637788591 0.413231903242805 no 1983 0.422444551116424 2827 2972920
SGTC_646 4092-0839 27.3 µM -0.195863346654434 0.41314274860263 no 1984 0.422358563345903 2884 877796
SGTC_2430 5571206 200 µM -0.197312243131392 0.412554920002317 no 1985 0.421791599522909 2894 1731771
SGTC_2575 plumbagin 510 nM -0.197522720471913 0.412469543983211 no 1986 0.421709251649267 2729 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3132 9126706 49.47 µM -0.197998953972032 0.412276384464735 no 1987 0.421522941069705 2969 850858
SGTC_54 0159-0055 9 µM -0.200596043734323 0.411223384214605 no 1988 0.420507225919049 2992 3319099
SGTC_578 3460-0051 92 µM -0.201620605936539 0.410808146861896 no 1989 0.420106667417867 2759 2876744
SGTC_439 amiodarone 34.4 µM -0.202790414151506 0.4103341660213 no 1990 0.419649425334526 2821 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_404 fumagillin 50 µM -0.202989872651349 0.410253362824142 no 1991 0.419571473942451 2802 12015870 A methionine aminopeptidase binder.
SGTC_2038 4100038 30.985 µM -0.20358242834371 0.410013333396682 no 1992 0.419339912861479 2873 3596803
SGTC_2965 9082772 38.63 µM -0.203863711298505 0.409899404531604 no 1993 0.419230001851486 2901 16459634
SGTC_470 aa-861 153 µM -0.204577589985373 0.409610294309719 no 1994 0.418951082842048 2785 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1173 0443-0020 122 µM -0.205023494025444 0.409429734748309 no 1995 0.418776884664951 2777 5331295
SGTC_2213 7173844 200 µM -0.205365453381637 0.40929127843653 no 1996 0.418643304609479 2787 892728
SGTC_1786 berberine 21.6 µM -0.206658628933475 0.40876778555806 no 1997 0.418138234596096 2770 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3313 9133968 57.047 µM -0.206875596595267 0.408679970377518 no 1998 0.418053507668886 2741 1494643
SGTC_2173 5763948 167 µM -0.207186913596773 0.408553976389806 no 1999 0.417931943509629 2752 2867177
SGTC_1980 st071811 45.7 µM -0.207365647941335 0.408481644575551 no 2000 0.417862154235506 2927 4974850
SGTC_2373 9071805 200 µM -0.208391359569736 0.408066610768469 no 2001 0.417461701153547 2872 10149009
SGTC_596 1155-0152 116 µM -0.208864770337549 0.407875089272531 no 2002 0.417276903388425 2774 280313
SGTC_1518 st038567 90.8 µM -0.208975474191702 0.4078303064609 no 2003 0.41723369233569 2733 77966
SGTC_1485 3909-9022 254 µM -0.209940712884963 0.407439891442113 no 2004 0.41685697297666 2778 714516
SGTC_3084 9116877 49.47 µM -0.210238822151926 0.407319332227125 no 2005 0.416740640450505 2750 27241325
SGTC_2741 miltefosine 3.04 µM -0.211257411743584 0.406907467828747 no 2006 0.416343206706997 2801 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1237 0330-0133 46.1 µM -0.214138448099937 0.405743086027305 no 2007 0.415219546939974 2782 X1237 YHR072W ERG7
SGTC_2202 7226349 200 µM -0.214479786069808 0.405605188011457 no 2008 0.415086464289975 2769 844334
SGTC_1801 st050089 28.441 µM -0.215265605565555 0.40528776729951 no 2009 0.414780121892796 2775 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2688 kanamycin b 96.69 µM -0.21655599737735 0.404766666919478 no 2010 0.414277190459715 2910 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_911 3456-4043 236 µM -0.217417204868444 0.404418978417166 no 2011 0.413941612160886 2878 914281
SGTC_1033 k072-0102 21.3 µM -0.219415264374471 0.403612608730722 no 2012 0.413163290235702 2970 5965931
SGTC_2634 4'-methoxyflavone 100 µM -0.219616340713038 0.40353148168852 no 2013 0.41308498202174 2864 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1782 st039423 80.636 µM -0.221125179618625 0.40292285233381 no 2014 0.412497482496507 2844 2068169
SGTC_3045 9092950 49.47 µM -0.221142131715509 0.402916015598374 no 2015 0.412490882936666 2876 44120432
SGTC_417 st075190 100 µM -0.221941119131229 0.402593819808928 no 2016 0.41217986011495 2941 222757
SGTC_394 menadione 8.33 µM -0.22256635593295 0.402341735972992 no 2017 0.411936511863696 2845 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_96 0929-0093 37.281 µM -0.224260786034651 0.401658777734915 no 2018 0.411277193656702 2802 6991579
SGTC_2802 7925815 54.55 µM -0.226346690371039 0.400818444104215 no 2019 0.410465893427301 2811 1262923
SGTC_121 0557-0495 61.343 µM -0.226591232489113 0.400719957107316 no 2020 0.410370805223175 2800 3104427
SGTC_1122 capsaicin 818.572 nM -0.226669235423205 0.400688543499575 no 2021 0.41034047552781 2946 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2986 9022445 71.43 µM -0.228074849279279 0.400122580144861 no 2022 0.409794026102472 3021 6459286
SGTC_3091 9116372 49.47 µM -0.228657294049956 0.399888123067446 no 2023 0.409567644905936 2968 17169793
SGTC_1037 k284-1091 78.7 µM -0.22918154181478 0.399677123443548 no 2024 0.409363909155697 2792 3334711
SGTC_1661 st013063 9.66 µM -0.229787391549953 0.399433317090451 no 2025 0.409128491337405 2822 721395
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.23060544422757 0.399104178160752 no 2026 0.408810668860689 2943 521171
SGTC_2835 9006588 71.43 µM -0.230741303999756 0.399049522677863 no 2027 0.408757891642166 3049 2345538
SGTC_1284 0929-0043 16 µM -0.231062396515156 0.398920357162033 no 2028 0.408633163947038 2869 1239883
SGTC_1519 esterone 74 µM -0.231403488526587 0.398783158595996 no 2029 0.408500677627081 2805 698 A steroid.
SGTC_2477 5967686 25.23 µM -0.231936389238881 0.398568833221245 no 2030 0.408293710266756 2804 776118
SGTC_916 4466-0038 42 nM -0.232550556367896 0.398321861549756 no 2031 0.408055212481345 2989 5722064 YGL116W CDC20
SGTC_695 3505-6186 243 µM -0.232840009917636 0.398205479288525 no 2032 0.407942821606413 2943 1819379
SGTC_745 0469-0705 296 µM -0.233967355056583 0.39775228751753 no 2033 0.407505161108839 3008 3486736
SGTC_407 eburnamonine 100 µM -0.234699655512061 0.397457977234969 no 2034 0.407220927564946 2797 3195
SGTC_653 0203-0016 55.2 µM -0.236065876853883 0.396909051388389 no 2035 0.406690776001993 2874 295302
SGTC_293 4049-0273 38.5 µM -0.236075762972157 0.396905080047297 no 2036 0.406686940392584 2871 1380311
SGTC_2882 9058044 58.44 µM -0.236962242188796 0.396549017020587 no 2037 0.406343041224785 2929 18076804
SGTC_2938 9059746 27.26 µM -0.237558592430293 0.396309535637251 no 2038 0.406111734799472 2947 6471769
SGTC_1903 st060211 78.3 µM -0.238795505230169 0.395812942969919 no 2039 0.405632077864266 2998 688960
SGTC_2706 st078239 82.5 µM -0.23929144977033 0.39561387983034 no 2040 0.40543979747426 2823 15434492
SGTC_1406 3909-7906 11.9 µM -0.23949741901063 0.39553121551376 no 2041 0.405359948785261 2866 X1406
SGTC_1796 st049173 110.4 µM -0.241765463063239 0.394621263458614 no 2042 0.404480950798005 2880 94134
SGTC_931 2812-0076 566 µM -0.24177014143192 0.394619387062947 no 2043 0.404479138156623 2811 3450959
SGTC_1550 gossypolone 36.6 µM -0.241961481301723 0.394542646744934 no 2044 0.404405004977034 2829 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2034 5197015 53.07 µM -0.24279621223424 0.394207910702271 no 2045 0.404081634994904 2985 780676
SGTC_506 n9-isopropylolomoucine 153 µM -0.243676606657465 0.393854947763003 no 2046 0.403740646248075 2979 6610355
SGTC_2650 prasterone 100 µM -0.243770126165645 0.393817459548074 no 2047 0.40370442916249 2845 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_428 3448-4153 16.5 µM -0.244086748552235 0.393690545656617 no 2048 0.403581817667905 2782 3834874
SGTC_1449 4112-4002 201 µM -0.244245326221513 0.393626986140696 no 2049 0.403520412288782 2874 2059539
SGTC_2363 9053361 176 µM -0.245354758921609 0.393182393780943 no 2050 0.403090877828871 3004 6469797 YMR079W SEC14
SGTC_907 3448-6986 75.5 µM -0.245739023038439 0.393028436812144 no 2051 0.402942131116335 3012 590582
SGTC_2937 9044753 11.33 µM -0.248432867320898 0.391949608272216 no 2052 0.401899753028797 2818 6465530 YGL099W LSG1
SGTC_2646 retinol 96.75 µM -0.248889523154047 0.391766809189193 no 2053 0.401723119828002 2922 445354 A vitamin A analog and teratogen.
SGTC_589 1227-0070 34.1 µM -0.249218035588215 0.391635320613415 no 2054 0.40159606454911 2978 2841384
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.249376971735208 0.391571710149795 no 2055 0.401534598229666 2858 5106787 A p450 inhibitor.
SGTC_206 4546-0025 72.014 µM -0.249586795184566 0.391487737677693 no 2056 0.401453455693029 2903 6620745 YIL048W NEO1
SGTC_1080 nisoldipine 24.4 µM -0.250014272540502 0.391316674591002 no 2057 0.401288155590564 2809 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2899 9053889 58.44 µM -0.252344724950795 0.390384470779637 no 2058 0.400387310439248 2925 6470052
SGTC_2582 agaric acid 100 µM -0.254118876735491 0.389675214613725 no 2059 0.399701860209888 2966 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2598 perillyl alcohol 100 µM -0.254822859914161 0.389393883509318 no 2060 0.399429959164059 3018 10819 An apoptosis inducer.
SGTC_1374 2889-5571 141 µM -0.254915103043692 0.389357024901076 no 2061 0.399394335498812 2928 2853281
SGTC_3176 9106582 49.47 µM -0.256780308321314 0.3886119381743 no 2062 0.398674186090861 2928 17018027
SGTC_1115 galangin 695.678 nM -0.256903351228516 0.388562801046825 no 2063 0.398626691741791 2955 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_178 4092-0806 87.505 µM -0.257348127150478 0.3883851948684 no 2064 0.398455021533018 2933 2169044
SGTC_295 k015-0027 31 µM -0.257691320743616 0.388248168094945 no 2065 0.398322572494361 2930 3887424
SGTC_3090 9117696 49.47 µM -0.258033211946141 0.388111675156646 no 2066 0.398190637734989 2931 7923821
SGTC_3356 9151811 4.48 µM -0.25866160510254 0.38786083833845 no 2067 0.397948173121615 2857 1859254 YPR165W RHO1
SGTC_727 3032-0951 202 µM -0.258945789370663 0.387747415354117 no 2068 0.397838533957666 2937 3652836
SGTC_1982 st072467 71.9 µM -0.262657475138729 0.386266898519348 no 2069 0.396407298046619 2822 3163533
SGTC_590 k048-0076 22.4 µM -0.263208999629552 0.386047047151461 no 2070 0.39619474730229 2984 6832814
SGTC_2449 5812982 45.77 µM -0.263858262132248 0.385788281877405 no 2071 0.395944569075596 2916 776185
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.264061507033193 0.385707288526904 no 2072 0.395866262176093 2908 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1442 4112-3290 3 µM -0.264629337791188 0.385481033668124 no 2073 0.395647508656173 2877 704353
SGTC_2322 7413319 38.22 µM -0.265501685815479 0.385133518399058 no 2074 0.395311505676079 3007 1840400
SGTC_711 k292-0785 179 µM -0.265662401955751 0.385069504334345 no 2075 0.395249610994294 2851 4146315
SGTC_1958 st076513 41.9 µM -0.26698319022824 0.384543546362287 no 2076 0.394741051861771 2855 732122 YGL099W LSG1
SGTC_1986 st071812 45 µM -0.267269513602739 0.38442955602852 no 2077 0.394630828918486 2912 11838594
SGTC_2175 5807670 165.306 µM -0.267650041769125 0.384278076589645 no 2078 0.394484353987526 3009 241186
SGTC_2915 7971052 15.16 µM -0.267689000882322 0.384262568867013 no 2079 0.394469358479414 2896 5741558
SGTC_283 0987-0079 11.7 µM -0.267944371129463 0.384160923016182 no 2080 0.394371069391078 2966 411556
SGTC_254 nsc-64875 3.808 µM -0.269220145629359 0.383653241782413 no 2081 0.393880139213489 3030 56993
SGTC_2774 tamoxifen 10.92 µM -0.271281431912714 0.382833396508919 no 2082 0.393087293188866 2848 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1471 k673-0312 37 µM -0.27236224294536 0.382403729797515 no 2083 0.392671750703391 2922 24099884
SGTC_3194 9111903 49.47 µM -0.272620215309439 0.382301196579689 no 2084 0.392572585399646 3095 17087251
SGTC_866 0495-0101 262 µM -0.272652237176688 0.382288469803271 no 2085 0.39256027659007 2872 635694
SGTC_1763 st044482 94.5 µM -0.274169368761319 0.381685646725765 no 2086 0.391977233345175 3026 88505
SGTC_3030 9087619 49.47 µM -0.274915004906866 0.381389477738458 no 2087 0.391690769458026 2937 25236973
SGTC_3224 9130643 49.47 µM -0.276098967648209 0.38091934680659 no 2088 0.391236026783003 3092 17644395
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.277645118293019 0.380305662073214 no 2089 0.39064239693311 2854 5355888
SGTC_2471 5466956 24.79 µM -0.278468751725357 0.379978875462193 no 2090 0.39032627462856 2912 724419
SGTC_2166 5933061 31.504 µM -0.279265324138776 0.379662907134215 no 2091 0.390020607691028 3384 2877375
SGTC_787 4152-0075 138 µM -0.279685137159704 0.379496416458684 no 2092 0.389859541133294 2907 9566539
SGTC_765 1319-0117 244 µM -0.280704896064741 0.37909209059386 no 2093 0.389468376583887 2886 3487746 YGL099W LSG1
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.28079540347297 0.379056211547598 no 2094 0.389433664674106 2905 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1118 chelidonine 707.474 nM -0.281130989512015 0.378923187257454 no 2095 0.38930496653217 3034 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2560 caryophyllene 100 µM -0.281345313620222 0.378838237970805 no 2096 0.389222779016774 2868 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2665 lovastatin 100 µM -0.281950403155998 0.378598436893913 no 2097 0.388990770255565 2930 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_889 0919-1524 82.7 µM -0.282278785831917 0.378468316176492 no 2098 0.388864875439694 2963 3905452
SGTC_3061 glucosamine 200 µM -0.282368294880396 0.378432850855377 no 2099 0.388830561629721 2991 91431 and experimental redox chemotherapeutic
SGTC_1803 st050068 52.4 µM -0.282665989729471 0.378314905417331 no 2100 0.388716444832491 2935 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_456 gingerol 170 µM -0.283041148665641 0.378166285183391 no 2101 0.388572647030992 3085 442793 A herb.
SGTC_3082 9117008 49.47 µM -0.283671471469449 0.377916621683583 no 2102 0.388331079726576 2930 41448529
SGTC_1022 4477-0945 21.3 µM -0.284820143245423 0.377461777385475 no 2103 0.38789096952521 2905 4648966
SGTC_836 0330-0104 1.35 µM -0.285101162083245 0.37735052704176 no 2104 0.387783319884892 2913 46494820
SGTC_1510 1123-0200 71.5 µM -0.286041366853004 0.376978390783348 no 2105 0.387423219207732 3100 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1250 0485-0349 40.2 µM -0.286159952266365 0.376931462378377 no 2106 0.387377807581288 2930 6842794 YDL195W SEC31
SGTC_421 streptovitacin 30 mM -0.286933395033111 0.376625428590272 no 2107 0.387081659791208 3089 91467 include heat shock
SGTC_1200 1643-0193 18.4 µM -0.287226016783497 0.376509664992092 no 2108 0.386969633352262 2990 5403974
SGTC_2004 4023728 41.89 µM -0.287622791643553 0.376352715297334 no 2109 0.386817748287278 3072 360084 YDR527W RBA50
SGTC_1788 fluconazole 20 µM -0.288377220928739 0.376054346934805 no 2110 0.386529001252395 3011 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_582 0987-0078 156 µM -0.289834128481132 0.375478366039599 no 2111 0.385971568599699 3010 1625765
SGTC_1079 idarubicin 2.36 µM -0.290045707922766 0.375394742239169 no 2112 0.385890634970553 3022 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1874 staurosporine 7.6 µM -0.291025864348181 0.375007425629936 no 2113 0.385515769174273 3042 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_403 arphamenine a 50 µM -0.291723227549957 0.374731933710753 no 2114 0.385249124156271 2923 5487158 An arginine aminopeptidase inhibitor.
SGTC_783 0848-0141 92.7 µM -0.29188383226381 0.374668496194516 no 2115 0.385187722735875 2888 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_368 fentichlor 4.58 µM -0.293488270539183 0.374034942968568 no 2116 0.384574481865041 2995 7329 A pesticide.
SGTC_2185 6113692 200 µM -0.296399009698553 0.372886432865242 no 2117 0.383462690758167 3060 874150
SGTC_2581 avocatin a 64 µM -0.29722903921389 0.372559128904303 no 2118 0.383145826517627 2980 6710728 A skin care supplement.
SGTC_2539 epi(13)torulosol 80 µM -0.299336774973543 0.371728403428804 no 2119 0.382341548902181 3045 6708597
SGTC_558 k064-0027 21.3 µM -0.299447722219553 0.371684692106567 no 2120 0.382299227266621 3035 5088526
SGTC_950 1165-0508 94.1 µM -0.30007301821768 0.371438367100696 no 2121 0.382060729857555 3018 6148369
SGTC_350 k064-0020 19.8 µM -0.301109918625223 0.371030013418159 no 2122 0.38166533892616 3133 2790705
SGTC_2804 7954240 19.48 µM -0.302287618768687 0.370566385878528 no 2123 0.381216407960138 3094 828705
SGTC_1456 k015-0012 13 µM -0.304366039438534 0.369748628718734 no 2124 0.380424518895835 3136 2989616
SGTC_749 1000-0129 128 µM -0.305038733340468 0.369484082404295 no 2125 0.380168326149261 3099 708470
SGTC_3217 9129673 49.47 µM -0.306164314791663 0.369041569931686 no 2126 0.379739770628446 3133 17248312
SGTC_3330 9141424 71.43 µM -0.306605679661728 0.368868098531501 no 2127 0.379571765000369 3072 27261020
SGTC_1343 1487-0095 224 µM -0.306683154632916 0.368837650988593 no 2128 0.37954227648143 3081 4560101 YGL055W OLE1
SGTC_2533 agelasine 13.65 µM -0.30747064581856 0.368528214918872 no 2129 0.379242581415786 3144 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_145 3737-0113 38.366 µM -0.309268715405244 0.367822002874588 no 2130 0.378558563348463 3076 6849351
SGTC_680 0417-1641 114 µM -0.31106108126788 0.36711847546362 no 2131 0.37787709353844 2926 2835990
SGTC_1872 amphotericin b 148 nM -0.312123853738986 0.366701533594043 no 2132 0.377473199402966 3076 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_851 0394-0702 453 µM -0.312861738886371 0.366412142430892 no 2133 0.377192853626261 3089 762646
SGTC_2438 5259590 200 µM -0.31303626621572 0.366343705660173 no 2134 0.377126554662262 3048 1201127
SGTC_1910 st062352 60.4 µM -0.314867252004627 0.365625984406809 no 2135 0.376431223467965 2902 2245730
SGTC_2459 5811157 9.22 µM -0.315971536552148 0.36519334716912 no 2136 0.376012056362624 2945 2870684 YBR192W RIM2
SGTC_1159 4092-0538 61.2 µM -0.316252840423783 0.365083165165292 no 2137 0.375905301683389 2978 717301
SGTC_3260 9137109 49.47 µM -0.318607512491114 0.36416131725646 no 2138 0.37501207798841 3031 17478346
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.319185813486461 0.363935033865461 no 2139 0.374792806990157 3117 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_182 3448-4371 550.524 µM -0.320488505695498 0.363425477340345 no 2140 0.374299021184659 2976 3491403
SGTC_564 3555-0129 330 µM -0.320490021215491 0.363424884675352 no 2141 0.374298446846315 2971 563260
SGTC_803 4488-1585 147 µM -0.321742555142812 0.362935175916071 no 2142 0.37382386813204 3102 747204
SGTC_2517 totarol 10 µM -0.321956853287457 0.362851413240967 no 2143 0.373742690796137 3072 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2746 daunorubicin 9.88 µM -0.325714142843654 0.361383871508605 no 2144 0.372320321413928 3012 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3332 9141069 11.198 µM -0.32627904284896 0.361163405569054 no 2145 0.372106621384643 2946 17332883
SGTC_2423 st077119 87.2 µM -0.326772422734453 0.360970889809757 no 2146 0.371920009427239 2992 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1441 4106-0040 13 µM -0.328705001445616 0.360217141333067 no 2147 0.371189336808063 2996 2904180
SGTC_939 1165-0479 45.3 µM -0.329123456939301 0.360054005848374 no 2148 0.371031187478222 3121 1377347
SGTC_3338 9144300 39.5675 µM -0.329868205987509 0.359763727400467 no 2149 0.370749774009074 3047 4901274
SGTC_35 0133-0054 64.071 µM -0.331805363542849 0.359009066850901 no 2150 0.370018116999167 3023 99677
SGTC_2603 homopterocarpin 100 µM -0.33348037583839 0.358356973673127 no 2151 0.369385850166707 3100 101795 A weak amylase inhibitor.
SGTC_165 k038-0023 64.381 µM -0.334575587153344 0.357930823884172 no 2152 0.368972631595321 3008 46368543
SGTC_443 clozapine 122 µM -0.335075080891001 0.357736528203816 no 2153 0.368784224972179 3057 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3018 9082602 49.47 µM -0.336220714880351 0.357291032797211 no 2154 0.368352216530995 3028 17332089
SGTC_1419 3993-2473 62.6 µM -0.336368543718915 0.357233561687913 no 2155 0.368296483692378 3030 704026
SGTC_2056 5235370 200 µM -0.336729817560813 0.357093123640516 no 2156 0.368160291778557 3012 5511916
SGTC_39 0986-0283 58.349 µM -0.338240995444661 0.35650589323287 no 2157 0.367590792301902 3184 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_991 3996-0057 64.7 µM -0.338516979532581 0.356398684926914 no 2158 0.367486816883884 3076 715343
SGTC_1138 3761-0006 1.03 µM -0.339883455744534 0.355868033249907 no 2159 0.366972148076503 3042 12061087
SGTC_3017 9080681 49.47 µM -0.340929253106338 0.35546210115753 no 2160 0.366578420955709 3070 16451914
SGTC_2055 5235184 200 µM -0.343388914981804 0.354508016438026 no 2161 0.365652948846807 3166 2836034
SGTC_509 pifithrin 175 µM -0.34473313793277 0.353986987324752 no 2162 0.36514750153715 3107 4817 A p53 inhibitor.
SGTC_487 nimodipine 119 µM -0.347020326567469 0.353101087424146 no 2163 0.36428802408581 3068 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2158 5657123 3.6195 µM -0.34748747873999 0.352920242422254 no 2164 0.364112561843161 3007 2858827
SGTC_285 1486-1325 46 µM -0.348807224344751 0.352409519148247 no 2165 0.363617019707322 3134 22310230
SGTC_658 3253-0951 102 µM -0.348815942919357 0.352406146064032 no 2166 0.363613746787598 3065 1184878
SGTC_902 1120-0002 2.07 µM -0.348841232234422 0.352396362077457 no 2167 0.363604253331285 3013 3280475
SGTC_1614 st002383 48.6 µM -0.349063508408604 0.352310371578308 no 2168 0.363520815800032 3106 1947235
SGTC_1082 camptothecin 424.86 nM -0.350527559338888 0.351744172773778 no 2169 0.362971405559475 2849 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2254 7938975 95.19 µM -0.350590365029492 0.351719890998453 no 2170 0.362947842944194 3199 2969277
SGTC_3048 9093155 49.47 µM -0.351280766349119 0.351453009698224 no 2171 0.362688861448252 3137 25236002
SGTC_2512 diallyl trisulfide 49.23 µM -0.351727921291294 0.351280196691603 no 2172 0.362521159385505 3088 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2524 avocatin b 10.57 µM -0.352192553691294 0.351100661700388 no 2173 0.362346930475414 3108 6710748
SGTC_1362 1611-0397 101 µM -0.352656806083106 0.350921306733222 no 2174 0.362172872535178 3049 27816
SGTC_747 3448-8087 38.7 µM -0.353705445532299 0.350516307368067 no 2175 0.361779820576648 3069 5168703
SGTC_1618 st003135 44.5 µM -0.354404799665182 0.350246301311564 no 2176 0.36151776904349 3109 1270615
SGTC_2125 5246583 200 µM -0.355148091907419 0.349959414618572 no 2177 0.361239324871902 3189 835267
SGTC_2806 7952793 58.44 µM -0.355218479411863 0.349932251760925 no 2178 0.361212960866789 3169 2972490
SGTC_2336 9001819 198.65 µM -0.35592213564961 0.349660749855119 no 2179 0.360949439022461 3263 2989602
SGTC_1765 st044815 90.4 µM -0.356344163619368 0.349497949544185 no 2180 0.360791419649203 3114 645695
SGTC_2208 7283366 200 µM -0.356907950199772 0.34928050802453 no 2181 0.36058035886699 3113 898663
SGTC_744 1594-0068 283 µM -0.360010081360983 0.348084962849897 no 2182 0.359419797261061 3044 668392
SGTC_2196 6573537 42.6665 µM -0.360757225383217 0.34779724237817 no 2183 0.359140470795519 3151 2903087
SGTC_442 cape 100 µM -0.361392571789641 0.347552643398566 no 2184 0.358903000087063 3167 5281787
SGTC_2602 kawain 100 µM -0.36257799280698 0.34709644353332 no 2185 0.35846007616448 3109 5369129
SGTC_1827 berberine 7.24 µM -0.362999718884222 0.346934198984231 no 2186 0.358302547162541 3039 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_981 1488-1094 54.9 µM -0.363119375596537 0.346888170303825 no 2187 0.35825785571017 2987 3449522
SGTC_1742 st038235 28.8875 µM -0.364024738174893 0.346539975227482 no 2188 0.357919768250167 3154 564103 YBR002C RER2
SGTC_721 1187-1332 279 µM -0.366757647477225 0.34548970774529 no 2189 0.356899900914749 2983 25730
SGTC_13 0199-0087 65 µM -0.367153513262466 0.345337673362123 no 2190 0.356752256247532 3070 4589825
SGTC_2801 7907800 81.82 µM -0.367694551660664 0.345129925016198 no 2191 0.356550501770257 3144 6620925
SGTC_385 1494-0393 12.4 µM -0.368132195259392 0.344961912422991 no 2192 0.356387332812876 3087 3090647
SGTC_1013 4112-3890 241 µM -0.369070062586056 0.34460196551347 no 2193 0.356037751379137 2996 705171
SGTC_1809 st050081 57.6 µM -0.369136713775559 0.344576390603175 no 2194 0.356012912361602 3207 5036894
SGTC_2191 5911152 200 µM -0.369160602369296 0.344567224418445 no 2195 0.356004009905579 3102 2875902
SGTC_2207 7258803 200 µM -0.369309212712399 0.344510203862964 no 2196 0.355948629713227 3133 3666799
SGTC_2935 9038016 29.96 µM -0.369577477698362 0.344407281760186 no 2197 0.355848667472979 3225 6463195
SGTC_527 4476-4215 268 µM -0.370508990197235 0.344049988701466 no 2198 0.355501639619522 3073 4418754
SGTC_870 0573-2213 57.6 µM -0.371662796404533 0.343607625156009 no 2199 0.355071964000111 3087 3916321
SGTC_858 0438-0351 2.77 µM -0.37286818120343 0.343145715282292 no 2200 0.354623277355594 3090 2799119
SGTC_3341 9147222 25.867 µM -0.373568843832916 0.342877325247649 no 2201 0.354362558688794 3188 1939759
SGTC_3318 9139014 38.6185 µM -0.373618156001554 0.342858439120307 no 2202 0.354344212051681 3048 16643984
SGTC_2447 5741742 33.78 µM -0.374473139734562 0.342531050323993 no 2203 0.354026168346731 3160 1776504
SGTC_2393 9031399 185.94 µM -0.374654420878527 0.34246164967045 no 2204 0.353958747008377 3198 1526623 YDL150W RPC53
SGTC_1808 st050063 61.5 µM -0.374994140431405 0.342331607671752 no 2205 0.3538324122401 3214 4011993
SGTC_63 0099-0242 26.702 µM -0.375017018009822 0.342322850984537 no 2206 0.353823905113829 3188 3898502 YLR359W ADE13
SGTC_2879 9041815 71.43 µM -0.375248718746366 0.342234169326907 no 2207 0.353737750308444 3151 4942971
SGTC_321 4534-3890 65.3 µM -0.375865682494681 0.341998073678844 no 2208 0.353508377167219 3168 699746
SGTC_1955 wogonin 32.4 µM -0.37608518528619 0.341914090679645 no 2209 0.353426783826349 3267 5281703 A flavanone.
SGTC_2785 7756463 72.73 µM -0.376955112215716 0.341581328718677 no 2210 0.353103481801559 3042 2201551
SGTC_1904 st060225 78 µM -0.377431734747434 0.341399064607193 no 2211 0.352926393434162 3120 66595
SGTC_488 nitrendipine 139 µM -0.379021895653405 0.340791242622027 no 2212 0.352335802213869 3091 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_818 4072-2707 53.5 µM -0.380065549035972 0.340392541713759 no 2213 0.351948379099861 3009 882871
SGTC_1070 indatraline 8.81 µM -0.38161852888749 0.339799595946047 no 2214 0.351372169259396 3092 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_720 r052-1644 49.9 µM -0.381986876069442 0.339659014780564 no 2215 0.351235549616863 3166 1422863 YOR257W CDC31
SGTC_2412 st077135 33.4 µM -0.382677728184827 0.339395408479852 no 2216 0.350979365026515 3305 13258915
SGTC_3262 9137218 49.47 µM -0.384049606214254 0.33887217825174 no 2217 0.350470840496774 3049 17650664
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.384365570598271 0.338751714355727 no 2218 0.350353757480244 3259 5393153
SGTC_839 0122-0028 230 µM -0.385045561530183 0.338492518438032 no 2219 0.35010182988475 3083 759448
SGTC_2201 6605497 169.863 µM -0.385570102447589 0.33829262851873 no 2220 0.349907539507227 3109 670741
SGTC_1513 0337-0559 19 µM -0.386530648409256 0.337926705721015 no 2221 0.34955185439587 3085 775073
SGTC_1050 3232-1156 69.3 µM -0.38829207924787 0.337256081483045 no 2222 0.34889994909407 3123 700529
SGTC_1453 4237-0541 195 µM -0.38837546256829 0.337224347997285 no 2223 0.34886909997477 3221 739892
SGTC_2920 7982904 15.77 µM -0.388837474889544 0.337048539320885 no 2224 0.348698188535116 3161 6456808
SGTC_324 1315-0088 19.6 µM -0.388989113098465 0.336990844474556 no 2225 0.348642099958296 3159 6787421
SGTC_2648 atorvastatin 78.68 µM -0.388992938401243 0.336989389084527 no 2226 0.348640685082035 3188 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2771 fluoxetine 41.05 µM -0.389350054167647 0.336853530139118 no 2227 0.348508606872926 3265 3386 A selective serotonin reuptake inhibitor.
SGTC_2779 methotrexate 400 µM -0.389647196000739 0.336740503532966 no 2228 0.348398723841264 3191 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2296 7971656 126.45 µM -0.390368605193839 0.336466155769505 no 2229 0.348131999717755 3159 666570
SGTC_315 k915-0449 187 µM -0.390715514649254 0.336334259082257 no 2230 0.348003764819752 3140 20970215 YNL149C PGA2
SGTC_806 3966-4455 5.86 µM -0.390776586919525 0.336311041188171 no 2231 0.347981191285935 3093 714982
SGTC_3173 9105693 49.47 µM -0.390835738239035 0.336288554178608 no 2232 0.347959328287551 3258 17096658
SGTC_882 0843-0131 351 µM -0.392725102380194 0.335570600610363 no 2233 0.3472612641332 3229 5425421
SGTC_2997 9067075 71.4286 µM -0.393477771191865 0.335284755322489 no 2234 0.346983319374857 3177 27209819
SGTC_345 1362-0200 395 µM -0.393505411014094 0.335274260204912 no 2235 0.346973114135837 3095 1419823
SGTC_625 k213-0058 121 µM -0.393807659425442 0.335159501845058 no 2236 0.346861524523844 3162 3655420
SGTC_123 0083-0120 66.675 µM -0.394581722142863 0.33486567413473 no 2237 0.346575802435547 3115 16001701
SGTC_2791 5663188 71.43 µM -0.396045257317599 0.33431040475799 no 2238 0.346035820787207 3259 54690634
SGTC_1326 1431-2094 10.8 µM -0.396279729931489 0.334221478831904 no 2239 0.345949339513624 3030 616278
SGTC_399 oxolinic acid 75 µM -0.396470723054846 0.334149049783976 no 2240 0.345878900855787 3088 4628 A DNA gyrase inhibitor.
SGTC_10 0279-0212 42.575 µM -0.396546527354817 0.334120304736862 no 2241 0.345850945552024 3124 39851 YBR002C RER2
SGTC_2029 5175081 200 µM -0.397358735196508 0.333812376008555 no 2242 0.345551470229679 3091 1380876
SGTC_1338 1486-1223 76 µM -0.397458103991311 0.333774710439079 no 2243 0.345514837837938 3149 3444526
SGTC_2368 9071271 200 µM -0.398313542619724 0.333450527218013 no 2244 0.345199539520543 3124 27209959
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.398370741149209 0.33342885528139 no 2245 0.345178461065614 3129 88881 An O-methylated flavonoid and antioxidant.
SGTC_1965 Pectolinarigenin 58.4 µM -0.403443716582175 0.331508975438376 no 2246 0.343310915980606 3121 5320438 An anti-inflammatory.
SGTC_1291 0993-0025 5.79 µM -0.404067128855182 0.331273347416483 no 2247 0.343081678090242 3227 4353356
SGTC_3094 9117742 49.47 µM -0.404346527527621 0.331167766163562 no 2248 0.342978957808841 3073 17149698
SGTC_579 4491-1009 110 µM -0.404752772591754 0.331014275196807 no 2249 0.342829623446394 3249 1271041
SGTC_1344 1488-0097 29.1 µM -0.405380933124425 0.33077699414796 no 2250 0.342598762022377 3207 747966
SGTC_1041 0206-0046 107 µM -0.406127931982975 0.33049491165691 no 2251 0.34232430168099 3171 50494
SGTC_1724 st037281 8.293 µM -0.408341652227402 0.329659530187327 no 2252 0.341511431875177 3084 574124 YDL195W SEC31
SGTC_1075 aripiprazole 15.2 µM -0.408393014674699 0.329640157839898 no 2253 0.341492580481707 3111 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1766 st045414 44.774 µM -0.40980288733254 0.32910857553674 no 2254 0.340975274005188 3138 253960
SGTC_2628 lathosterol 100 µM -0.410766578630711 0.328745421330697 no 2255 0.340621850995667 3287 6710616
SGTC_2087 5276107 200 µM -0.41223552863705 0.328192178194267 no 2256 0.340083399199979 3096 144405
SGTC_795 0685-0265 78 µM -0.412403948338627 0.328128771187445 no 2257 0.340021684832126 3160 302754
SGTC_1699 st031318 29.054 µM -0.412473442424732 0.328102609349532 no 2258 0.339996221224399 3230 5340658
SGTC_1792 st045773 43.6 µM -0.413091969949278 0.327869794804448 no 2259 0.339769616235371 3101 2919270
SGTC_1644 st010134 20.9 µM -0.416645705180918 0.326533462688924 no 2260 0.338468786676417 3261 3818134
SGTC_322 k048-0136 19.3 µM -0.416872590531222 0.326448220961957 no 2261 0.338385801483233 3224 6823282
SGTC_3155 9099265 49.47 µM -0.417039210760807 0.326385626851159 no 2262 0.338324863754474 3225 25236499
SGTC_205 1486-1330 71.903 µM -0.417650608007446 0.326155985548685 no 2263 0.338101294780838 3150 4118834
SGTC_2506 ethyl hematommate 54.16 µM -0.41766288801283 0.326151373843546 no 2264 0.338096804949001 3199 3940691 An allergen.
SGTC_773 4358-1457 44.6 µM -0.418006125076899 0.326022483345256 no 2265 0.33797131947804 3271 1186886
SGTC_2421 5690543 90.72 µM -0.419648387884989 0.325406077673781 no 2266 0.337371167110067 3235 3397993
SGTC_3310 9130229 44.1445 µM -0.41994540487006 0.32529464646302 no 2267 0.337262668639945 3260 7761258
SGTC_2129 girgensonine 121.053 µM -0.420061571335088 0.3252510687935 no 2268 0.337220237428642 3179 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1494 4358-1428 177 µM -0.420075232019097 0.32524594440125 no 2269 0.337215247834049 3283 1564571
SGTC_348 k064-0012 10.7 µM -0.420549651137777 0.325068000932179 no 2270 0.337041982986865 3103 5066323
SGTC_767 0929-0023 86 µM -0.421170739965024 0.324835105402075 no 2271 0.336815204454654 3249 1204563
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.421652697605182 0.324654428364995 no 2272 0.336639267843341 3152 641818 YHR062C RPP1
SGTC_1195 1502-0147 41.1 µM -0.422441733436206 0.324358722440344 no 2273 0.336351310817711 3157 817940
SGTC_2070 5230947 200 µM -0.42398191028268 0.323781831530905 no 2274 0.335789503024314 3264 2835538
SGTC_2112 5488546 200 µM -0.425636572841659 0.323162530111613 no 2275 0.335186343144274 3131 600757
SGTC_3093 9117344 49.47 µM -0.427265573015252 0.32255331192186 no 2276 0.334592952564517 3276 24824913
SGTC_3177 9107506 49.47 µM -0.42775798332934 0.322369252526101 no 2277 0.33441366506876 3229 8897194
SGTC_847 0342-0274 5.54 µM -0.428450356834689 0.32211052199687 no 2278 0.334161634491652 3251 18097
SGTC_1511 0906-3109 28.5 µM -0.428502494285723 0.32209104243083 no 2279 0.334142658986148 3191 2882180
SGTC_3326 9140064 16.379 µM -0.428854105069662 0.321959686565406 no 2280 0.334014700772254 3108 1868434
SGTC_92 0063-0024 660.874 µM -0.430410784566923 0.321378404730301 no 2281 0.33344842586058 3213 3594437
SGTC_2276 7947513 42.08 µM -0.43170701275002 0.320894711887616 no 2282 0.332977184949682 3209 2105100
SGTC_396 dithiazanine 1.25 µM -0.431854872676546 0.320839556642549 no 2283 0.332923447536941 3160 10578 An antihelmenthic.
SGTC_951 1171-0579 82.7 µM -0.433644452520859 0.320172314926621 no 2284 0.332273324670358 3192 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2178 5812956 200 µM -0.433851721756646 0.320095072464426 no 2285 0.332198059960233 3154 5403383
SGTC_1188 1403-0014 4.57 µM -0.434272035134475 0.319938459361263 no 2286 0.33204545430545 3183 9614867
SGTC_1860 st056228 74.6 µM -0.434307293091237 0.319925323340968 no 2287 0.33203265425723 3261 688679
SGTC_1895 st058434 18.3 µM -0.43468864658419 0.319783257298139 no 2288 0.33189422021719 3322 5393175
SGTC_2014 4013930 200 µM -0.435279272709989 0.319563282864423 no 2289 0.331679864013007 3288 64556
SGTC_1524 corynanthine 62.1 µM -0.438558389129334 0.318343155788961 no 2290 0.330490776670684 3306 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1638 st008370 60.6 µM -0.439326771439741 0.318057532378923 no 2291 0.330212389300465 3232 24207134
SGTC_2220 6782180 200 µM -0.442144489584747 0.317011055679963 no 2292 0.329192326044323 3229 833803
SGTC_1339 1486-1321 22.7 µM -0.442520542978905 0.316871503026476 no 2293 0.32905628405629 3198 3469382
SGTC_2020 4017018 200 µM -0.44260377642155 0.316840618784781 no 2294 0.3290261763833 3276 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1483 3453-0561 55.9 µM -0.443745434272858 0.31641712904925 no 2295 0.328613321442531 3268 4546991
SGTC_1091 telmisartan 47.6 µM -0.444447950941362 0.316156655109575 no 2296 0.328359375951327 3299 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1137 ixabepilone 100 µM -0.444708882757628 0.316059931962956 no 2297 0.328265074591196 3237 154225 A novel microtubule stabilizer.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.444883636947171 0.315995160488028 no 2298 0.328201924141824 3187 4174840
SGTC_2944 9067346 25.62 µM -0.445732913461666 0.315680462263764 no 2299 0.327895093315819 3319 6473075
SGTC_977 1348-1378 135 µM -0.446138965835798 0.315530047315833 no 2300 0.327748433726599 3152 X977
SGTC_1036 k216-0215 33.5 µM -0.45103360710115 0.31371932392265 no 2301 0.325982663774762 3212 622330
SGTC_2743 auranofin 4.32 µM -0.451792154381007 0.31343910667036 no 2302 0.325709361126327 3209 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2954 9074818 52.69 µM -0.454088344157389 0.312591520877485 no 2303 0.32488262111766 3324 16648742
SGTC_808 0711-0032 135 µM -0.454909967913302 0.312288477628344 no 2304 0.324587005720522 3277 4252555
SGTC_2248 tofa 1.1 µM -0.456219064047743 0.311805900011368 no 2305 0.324116228918594 3119 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1423 4048-0112 5.59 µM -0.456343839963005 0.311759920185572 no 2306 0.324071371699554 3287 X1423
SGTC_1685 st024049 53.0905 µM -0.45748854025129 0.311338236045388 no 2307 0.323659968668038 3265 1941139
SGTC_1844 rapamycin 4 nM -0.458190839699926 0.311079645740281 no 2308 0.323407670211572 3207 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1280 0880-0253 10.1 µM -0.458332357369028 0.311027549481999 no 2309 0.323356840340294 3223 6836607
SGTC_3245 9134821 49.47 µM -0.461932242740869 0.309703615551342 no 2310 0.322064955616674 3216 17014901
SGTC_865 0488-0499 301 µM -0.462716207839691 0.309415622082363 no 2311 0.321783899569785 3363 9634651
SGTC_181 1447-1644 8.07 µM -0.463298830966366 0.309201668370538 no 2312 0.321575091811148 3284 534600
SGTC_2067 5224629 34.075 µM -0.464234376602928 0.308858248082183 no 2313 0.321239917196303 3345 2835000
SGTC_1252 0493-0875 34.8 µM -0.465046125868966 0.308560406322726 no 2314 0.320949212584899 3186 3960963
SGTC_1327 1436-0082 2.18 µM -0.466325992755083 0.308091061716477 no 2315 0.320491088068647 3224 15992205
SGTC_2553 4-methylesculetin 85.09 µM -0.468538861210932 0.307280313002802 no 2316 0.319699643639606 3275 5319502
SGTC_3162 9099653 49.47 µM -0.468863339763524 0.307161509859975 no 2317 0.319583660997508 3329 25237511
SGTC_367 0335-0881 7.1 µM -0.469416541796972 0.306959009582765 no 2318 0.319385963397526 3352 23828853
SGTC_3269 9137823 49.47 µM -0.469645154391792 0.306875342853987 no 2319 0.31930427918862 3194 17682936
SGTC_604 1000-0114 314 µM -0.46967705635418 0.306863668300231 no 2320 0.319292881185051 3350 1572745
SGTC_1914 st062367 72.6 µM -0.470501800861581 0.306561920271411 no 2321 0.318998273950877 3213 978205
SGTC_2298 7976326 193.81 µM -0.47186106141913 0.306064895772195 no 2322 0.318512981568499 3245 2235818
SGTC_1838 st055369 84.5 µM -0.473297207627714 0.305540145054309 no 2323 0.318000577022558 3282 676036
SGTC_1849 st056239 19.2 µM -0.47352542791413 0.305456792812525 no 2324 0.317919182037847 3207 5393181
SGTC_2619 obliquin 87.91 µM -0.476587744757059 0.304339328389155 no 2325 0.316827855949266 3251 6708593 A bioactive alkalod. YER133W GLC7
SGTC_57 miconazole 162.5 nM -0.476607578336292 0.3043320968897 no 2326 0.316820792982229 3285 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_726 3448-4391 34.2 µM -0.476985442218974 0.304194338972793 no 2327 0.316686244036967 3436 1356692
SGTC_2988 9073640 71.4286 µM -0.477072554992559 0.304162584190965 no 2328 0.316655228549943 3417 9102229
SGTC_1836 st055642 81 µM -0.477314530844923 0.304074385698892 no 2329 0.316569082633288 3238 8571
SGTC_2919 7978188 46.38 µM -0.477543595862583 0.30399090361913 no 2330 0.316487542274869 3393 2980291
SGTC_2507 purpurin 79.67 µM -0.47794199544531 0.303845732395976 no 2331 0.316345745077301 3211 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1669 st015249 58.4 µM -0.478296143001417 0.303716711960285 no 2332 0.316219720595002 3357 722793
SGTC_1342 1486-1464 234 µM -0.479496435604144 0.303279612158596 no 2333 0.3157927516705 3245 3253938
SGTC_308 4092-1169 104 µM -0.480315203751256 0.302981610129885 no 2334 0.31550163980858 3253 2268590 YDL196W YDL196W
SGTC_2966 9084041 48.03 µM -0.480618598794158 0.302871218578307 no 2335 0.315393797185517 3107 17741380
SGTC_1891 st059073 26.2 µM -0.481606937345929 0.302511732416122 no 2336 0.3150425985451 3370 688754
SGTC_2096 5468907 200 µM -0.482996097578876 0.302006779932456 no 2337 0.314549253546898 3314 759785
SGTC_2793 7325131 81.82 µM -0.483113408187925 0.301964155478521 no 2338 0.314507607114239 3259 4176441
SGTC_1633 st005664 67.9 µM -0.48785130382819 0.30024491933351 no 2339 0.31282758446955 3214 2063822
SGTC_3254 9136651 49.47 µM -0.489994481847342 0.299468682433793 no 2340 0.312068901810703 3281 16454030
SGTC_1440 4100-1550 40 µM -0.490062433622886 0.299444085890547 no 2341 0.31204485996718 3300 742806
SGTC_3208 9114115 49.47 µM -0.491944463143864 0.298763210907532 no 2342 0.311379302379122 3303 650895
SGTC_684 1140-0066 328 µM -0.493734494222459 0.298116272537525 no 2343 0.310746850428154 3332 6813534
SGTC_8 0354-0001 70 µM -0.494526093410087 0.29783038291016 no 2344 0.310467341492866 3329 4993152
SGTC_2713 st079149 53.4 µM -0.495604071953445 0.297441267280975 no 2345 0.310086889667947 3335 3103253
SGTC_2489 cantharidin 73.42 µM -0.495821331740869 0.297362871596747 no 2346 0.310010236591677 3374 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2330 7979373 200 µM -0.496847631571263 0.296992670835816 no 2347 0.309648251622168 3251 1863007
SGTC_1238 0333-0287 48.8 µM -0.49759341892766 0.296723787197325 no 2348 0.309385321621785 3289 7226
SGTC_884 0851-0618 334 µM -0.497594741001427 0.296723310640328 no 2349 0.309384855606539 3365 9642473
SGTC_694 1315-0438 43.2 µM -0.497803142863899 0.296648194126485 no 2350 0.309311400267172 3272 6793154
SGTC_1967 st070177 51.4 µM -0.499810155444363 0.295925231347634 no 2351 0.308604379583393 3417 5729214
SGTC_3125 9127534 49.47 µM -0.500627132796913 0.295631172980586 no 2352 0.3083167816402 3306 1639235
SGTC_118 0083-0097 135.343 µM -0.500812862034429 0.295564341355956 no 2353 0.308251416368173 3413 5207356
SGTC_1804 st050076 49.1 µM -0.501094481306919 0.29546301852641 no 2354 0.308152315298522 3366 3895976
SGTC_2200 6600604 21.907 µM -0.502754123081079 0.294866226479888 no 2355 0.307568576022638 3295 2904777
SGTC_369 0957-0393 4.5 µM -0.503477013466388 0.294606455512035 no 2356 0.307314468774983 3313 6997992
SGTC_2900 5328528 85.29 µM -0.504724582388505 0.294158389599383 no 2357 0.306876146386901 3356 795359
SGTC_192 3455-0609 60.9 µM -0.505728535031942 0.293798047590669 no 2358 0.306523616773295 3407 3769639
SGTC_2433 5607874 27.82 µM -0.506192924935805 0.293631436338608 no 2359 0.306360610638092 3305 2252428
SGTC_203 k066-0004 30.888 µM -0.508515016101592 0.292798986180214 no 2360 0.305546105531607 3406 6795412
SGTC_1727 st034309 9.9045 µM -0.50859686006218 0.292769665809297 no 2361 0.305517415164939 3453 870305
SGTC_1493 4348-0038 111 µM -0.510094263462857 0.292233466027972 no 2362 0.30499271196577 3403 800424
SGTC_3339 9145883 14.936 µM -0.510185209914071 0.292200914062889 no 2363 0.304960856433131 3365 2030670
SGTC_859 0439-0102 54.6 µM -0.510672449061098 0.292026547960402 no 2364 0.304790217857194 3419 610143
SGTC_986 1493-0483 84 µM -0.511327218591844 0.29179230482237 no 2365 0.304560974450413 3389 40079
SGTC_1832 st054113 55 µM -0.513095022794808 0.29116031230937 no 2366 0.303942426480806 3390 1251267
SGTC_1435 4092-0789 56.7 µM -0.513506841654316 0.291013178326473 no 2367 0.303798413112697 3394 2248285
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.513624158879109 0.290971269774379 no 2368 0.303757392762343 3376 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2065 5221596 34.26 µM -0.51386778375015 0.290884250083755 no 2369 0.303672216427776 3384 788581
SGTC_1097 itavastatin 7.23 µM -0.515085162081201 0.290449600460683 no 2370 0.303246755414845 3357 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2729 fluphenazine 10.66 µM -0.516600139998219 0.289909121621587 no 2371 0.302717658976736 3286 3372 An atypical antipsychotic.
SGTC_2952 9073731 13.78 µM -0.520093784989992 0.288664540959958 no 2372 0.301499104977134 3321 16457353
SGTC_780 0109-0199 192 µM -0.520122633593488 0.288654274379483 no 2373 0.301489052020555 3451 610414
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.521986502831556 0.287991329302277 no 2374 0.30083986407238 3371 688788
SGTC_204 PMA1.184 62.41 µM -0.524224546722182 0.287196247946652 no 2375 0.300061184896243 3342 2252213 YGL008C PMA1
SGTC_2240 6690706 185.951 µM -0.524637908906904 0.287049511778185 no 2376 0.299917464233365 3237 805876
SGTC_229 benomyl 22.8748 µM -0.52519547189334 0.286851643171719 no 2377 0.299723656196481 3395 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_568 1193-0097 7.48 µM -0.525550809713932 0.286725574201771 no 2378 0.299600170918944 3340 3646150
SGTC_1119 parthenolide 318.541 nM -0.526632515239742 0.2863419617446 no 2379 0.299224403840977 3482 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1654 st012436 41.8 µM -0.527164239847823 0.28615348205499 no 2380 0.299039769707605 3384 4323132
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.527945555524596 0.285876637129825 no 2381 0.298768562365817 3413 165521
SGTC_1625 st003711 30.1 µM -0.528999574496373 0.285503366678857 no 2382 0.298402872528105 3481 24207034 YER133W GLC7
SGTC_1366 1683-0113 21.9 µM -0.529613379529532 0.285286100618526 no 2383 0.298190007961841 3337 708623
SGTC_2145 5634607 200 µM -0.530036006170604 0.285136550995665 no 2384 0.298043483336861 3327 308662
SGTC_1157 4092-0394 27.6 µM -0.530592611928523 0.284939648884041 no 2385 0.297850558239275 3509 3659885
SGTC_1242 0402-0103 60.1 µM -0.530907393686383 0.284828321956532 no 2386 0.297741476964163 3355 432868
SGTC_90 0870-0863 4.608 µM -0.531530238122362 0.284608105574861 no 2387 0.297525696498938 3358 1738164
SGTC_2953 9074162 66.49 µM -0.532326824683721 0.284326578484054 no 2388 0.29724982828466 3393 16451992
SGTC_702 1488-0190 94 µM -0.533532728205749 0.28390064531772 no 2389 0.296832430901238 3412 949357
SGTC_1672 st016598 6.51 µM -0.535409143826116 0.283238490748177 no 2390 0.296183484308082 3343 4665860 YNL267W PIK1
SGTC_663 1486-0733 13.9 µM -0.536219630978582 0.282952713139239 no 2391 0.295903383824678 3345 722445 YPR165W RHO1
SGTC_67 0335-0847 266 µM -0.539340435971191 0.281853612624105 no 2392 0.294825986255423 3534 4552207 YOR254C SEC63
SGTC_2626 ethyl orsellinate 100 µM -0.54077079774928 0.28135054920502 no 2393 0.294332786608851 3341 75653 A natural product.
SGTC_2472 5377652 49.4 µM -0.540919166729233 0.281298392115871 no 2394 0.294281649670624 3390 1610903
SGTC_956 1185-0240 191 µM -0.542758377485017 0.280652230545353 no 2395 0.293648087228837 3350 1416193
SGTC_1053 3366-3204 134 µM -0.5429756037796 0.280575960854794 no 2396 0.293573299873605 3366 3632071 YPR165W RHO1
SGTC_1776 st049249 45.9 µM -0.545000371814332 0.27986553330455 no 2397 0.292876630944837 3395 1822314
SGTC_2571 chrysanthemic acid 100 µM -0.545324579757138 0.279751859998856 no 2398 0.292765150910578 3363 2743 An insecticide.
SGTC_1800 st050079 29.0735 µM -0.547584017473347 0.278960281985426 no 2399 0.291988783068987 3405 3645560
SGTC_1365 1672-3266 55.4 µM -0.548329380229359 0.278699388625749 no 2400 0.291732878601902 3461 6415873
SGTC_1236 0330-0013 258 µM -0.548594205561151 0.278606722543642 no 2401 0.291641981621751 3360 4617066
SGTC_1610 st001799 48.1 µM -0.549151717716914 0.278411690312421 no 2402 0.291450667823847 3328 621897
SGTC_2691 st077356 60.2 µM -0.549455690578977 0.27830538074443 no 2403 0.291346382294437 3489 2839272
SGTC_778 3456-2434 196 µM -0.549567318074127 0.278266345810595 no 2404 0.291308090048809 3442 5539063
SGTC_1351 1496-0003 46.5 µM -0.549849171808798 0.278167796472839 no 2405 0.291211414535008 3451 3891978
SGTC_1487 3970-0795 2.82 µM -0.550923849473577 0.277792194810256 no 2406 0.290842938812847 3452 3765103
SGTC_618 k072-0232 33.2 µM -0.551517375598018 0.277584862628765 no 2407 0.290639529431458 3397 5872756 YGL099W LSG1
SGTC_1923 st058458 19.1 µM -0.551646489530184 0.277539770209016 no 2408 0.290595289165814 3503 3534982
SGTC_2593 nobiletin 86.24 µM -0.55306774124071 0.277043641592991 no 2409 0.290108512480864 3370 72344 An anti-infammatory.
SGTC_372 0155-0182 15.9 µM -0.553594965746397 0.27685970922298 no 2410 0.28992803606121 3427 771486
SGTC_17 0960-0276 49.807 µM -0.553873199432693 0.276762666185011 no 2411 0.289832813956591 3433 6821114
SGTC_2370 9071495 200 µM -0.554267104755976 0.276625307407092 no 2412 0.289698029729789 3401 21791103
SGTC_717 1532-0246 73.2 µM -0.556393022698058 0.275884555571092 no 2413 0.288971103821844 3413 9561992
SGTC_3321 9137793 26.8275 µM -0.556413516587967 0.275877419454115 no 2414 0.288964100420369 3442 4904192
SGTC_1260 0700-1617 7.75 µM -0.557342104472458 0.275554173781058 no 2415 0.288646856791981 3431 2853078
SGTC_1043 0916-0009 19.3 µM -0.558434338039065 0.275174200849928 no 2416 0.288273915198657 3498 3101130
SGTC_742 0kpi-0133 140 µM -0.558641047640804 0.275102318485743 no 2417 0.288203360081603 3462 2728852
SGTC_1506 4226-2149 212 µM -0.561490018768889 0.27411254429654 no 2418 0.287231766360831 3440 991114
SGTC_378 3970-0959 8.33 µM -0.561598333519569 0.274074948912434 no 2419 0.287194858045169 3455 6615653
SGTC_528 3492-0019 172 µM -0.562912743558936 0.273618928419548 no 2420 0.286747151055762 3474 2869262
SGTC_2499 avocadenofuran 51.48 µM -0.564502683153567 0.273067818100637 no 2421 0.286206037311142 3329 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3054 9094397 49.47 µM -0.565699316915794 0.272653399990644 no 2422 0.28579909983525 3403 2598354
SGTC_116 0155-0182 31.788 µM -0.566028501097536 0.272539451720487 no 2423 0.285687202936662 3414 771486
SGTC_605 1315-0399 119 µM -0.56654773764774 0.272359764222685 no 2424 0.285510745463486 3518 24020461
SGTC_2463 5473429 200 µM -0.567864913010745 0.271904205421225 no 2425 0.285063349173659 3402 5399405
SGTC_1193 1488-0126 41.5 µM -0.569054593102811 0.271493068246204 no 2426 0.284659545864365 3463 1384710
SGTC_2292 7671323 168.05 µM -0.570152876615476 0.271113791564565 no 2427 0.284287007128074 3475 937504
SGTC_346 4513-0042 7.16 µM -0.570687629542176 0.270929217898378 no 2428 0.284105702862143 3456 2827372
SGTC_200 k038-0079 37.545 µM -0.571227620278021 0.270742900012434 no 2429 0.283922678890389 3389 3436683
SGTC_577 r071-0003 38.6 µM -0.571804736622544 0.270543843087089 no 2430 0.283727134000382 3457 4568517 YMR134W ERG29
SGTC_1744 st037937 38.9 µM -0.572201349314427 0.27040708724332 no 2431 0.283592786740551 3505 1016152
SGTC_716 1683-5115 658 µM -0.572930143033152 0.270155882314249 no 2432 0.283345997076246 3514 723597
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.573193092191294 0.270065276106228 no 2433 0.283256980522061 3468 6312947
SGTC_2003 4023581 200 µM -0.573416772270576 0.269988213085111 no 2434 0.283181268345056 3484 16641307
SGTC_2082 5219693 150 µM -0.573915698506241 0.269816360980289 no 2435 0.283012424677032 3465 2834649
SGTC_980 1473-0395 201 µM -0.574155990603321 0.269733613375698 no 2436 0.282931123691045 3437 768876
SGTC_1038 k292-0204 154 µM -0.576453830826755 0.268942965649292 no 2437 0.282154233996582 3434 4454212
SGTC_245 methotrexate 289.6 µM -0.577796995203133 0.268481345078815 no 2438 0.281700592092426 3460 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_735 3076-0345 636 µM -0.578747882505405 0.268154783832182 no 2439 0.281379651034524 3533 2888990
SGTC_2437 5741531 144.16 µM -0.581463082529907 0.267223410003094 no 2440 0.280464196243586 3551 2262990
SGTC_1219 1469-0211 33.1 µM -0.581612397853853 0.26717223893458 no 2441 0.280413895053709 3477 6822282
SGTC_715 0868-0130 184 µM -0.581778243045844 0.267115408800359 no 2442 0.280358030419512 3549 2876258
SGTC_903 1134-0042 114 µM -0.582239155446375 0.266957500108387 no 2443 0.280202801271054 3426 701009
SGTC_2928 9011484 9.79 µM -0.58303390680969 0.266685328902743 no 2444 0.279935237455448 3484 2994751
SGTC_3024 9090631 49.47 µM -0.584014066049656 0.266349856049273 no 2445 0.279605424277324 3470 25236383
SGTC_927 2425-1185 123 µM -0.584651310630609 0.266131865016137 no 2446 0.27939109947125 3428 730375
SGTC_4 0960-0234 25.671 µM -0.588093691407472 0.264955846655666 no 2447 0.278234703663217 3501 6821112
SGTC_2978 9011784 42.97 µM -0.588412436269639 0.264847087782235 no 2448 0.278127746157995 3476 2994934
SGTC_1772 st048439 82.2 µM -0.589571466431223 0.264451806700684 no 2449 0.277738993019149 3472 2927068 YDL195W SEC31
SGTC_2286 7945697 125 µM -0.58986676627714 0.264351144270918 no 2450 0.27763998821128 3456 1245733
SGTC_1176 0848-0131 83.3 µM -0.590319015573498 0.264197018405426 no 2451 0.277488396587482 3508 6769040
SGTC_3010 9080089 71.4286 µM -0.591530182056961 0.263784480260663 no 2452 0.277082619202488 3508 17027233
SGTC_1130 3454-2858 15.9 µM -0.593390766733445 0.263151382861267 no 2453 0.276459833348686 3429 715628 YIL048W NEO1
SGTC_276 colchicine 750 µM -0.595959783040784 0.262278506612103 no 2454 0.275601046894782 3551 2833 A microtubule depolymerizer.
SGTC_2929 9013348 24.6 µM -0.596321211881774 0.262155822823836 no 2455 0.275480331592997 3481 2995952
SGTC_2046 4110841 106 µM -0.597277578719364 0.26183133456374 no 2456 0.275161035697828 3531 44119630 YMR134W ERG29
SGTC_1714 st033236 13.627 µM -0.598181090547516 0.261524968975311 no 2457 0.27485955365118 3589 2916566
SGTC_1730 st033808 45.1 µM -0.598858460669155 0.261295404981021 no 2458 0.274633636956067 3448 1045166
SGTC_3180 9109287 49.47 µM -0.599422806921119 0.261104224402542 no 2459 0.274445485982056 3519 18891271
SGTC_2028 5153890 36.43 µM -0.599806976350036 0.260974122512123 no 2460 0.274317441703524 3496 2830968 YPR165W RHO1
SGTC_541 4513-1321 94 µM -0.601009366635462 0.260567139469401 no 2461 0.273916873839196 3444 747515
SGTC_125 0133-0007 11.75 µM -0.601302947602744 0.2604678183305 no 2462 0.273819113342988 3586 26541
SGTC_3235 9132602 49.47 µM -0.60225915490231 0.260144459829861 no 2463 0.273500822375744 3564 4912240
SGTC_2479 5617353 43.85 µM -0.60232632129823 0.260121754099254 no 2464 0.27347847170666 3555 2731746
SGTC_526 4469-0568 170 µM -0.603476049928247 0.259733244579614 no 2465 0.273096021780941 3539 2901964
SGTC_147 4466-0538 29.23 µM -0.605679633674861 0.258989460448688 no 2466 0.272363755335114 3614 6742687 YHR072W ERG7
SGTC_1011 4112-3381 17.4 µM -0.606004984549334 0.258879736918466 no 2467 0.27225572163398 3580 2877139
SGTC_2903 5923464 63.88 µM -0.606893044328698 0.258580364092356 no 2468 0.271960947238613 3552 2876576
SGTC_855 0428-0020 25 µM -0.607058882256588 0.258524478527477 no 2469 0.271905918116973 3505 6812414
SGTC_2504 purpurogallin 52.29 µM -0.607401286883873 0.258409111713518 no 2470 0.271792317329942 3447 5281571 An antioxidant.
SGTC_344 k064-0035 6.43 µM -0.607689007263427 0.258312190357554 no 2471 0.271696877593533 3449 5088750
SGTC_3149 9097855 49.47 µM -0.608485927774605 0.258043838462344 no 2472 0.271432618191332 3515 25236625 YMR079W SEC14
SGTC_1189 1431-2119 7.28 µM -0.608493301501949 0.258041356137516 no 2473 0.271430173656174 3568 3107275
SGTC_464 bw-b 70c 158 µM -0.608908132461647 0.257901725521919 no 2474 0.271292666729442 3557 5353454
SGTC_1583 clindamycin 39.6 µM -0.609561264161306 0.25768196320732 no 2475 0.271076238975924 3463 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1165 k072-0275 30.3 µM -0.610764353347703 0.257277408726929 no 2476 0.270677797768668 3579 6153523 YGL055W OLE1
SGTC_3004 9076122 71.4286 µM -0.61241017289138 0.256724515569572 no 2477 0.270133206445338 3533 44782551
SGTC_583 1488-1091 88.9 µM -0.613271766462705 0.25643532051037 no 2478 0.269848329281035 3598 4303273
SGTC_820 1582-0060 59.9 µM -0.613548752903441 0.256342385702373 no 2479 0.269756778486843 3471 3848840
SGTC_2053 5265679 138 µM -0.615549224568543 0.255671706724418 no 2480 0.269096035858095 3508 764595
SGTC_1557 sumaresinolic acid 42.3 µM -0.615552214261408 0.255670705084896 no 2481 0.269095048990321 3504 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1820 st053765 18.6 µM -0.617258824647232 0.255099272464799 no 2482 0.268532010517545 3527 3690829
SGTC_337 1315-0038 354 µM -0.617399293721913 0.255052268296998 no 2483 0.268485693880029 3528 1626437
SGTC_891 0929-0073 133 µM -0.617524339109762 0.255010429059968 no 2484 0.268444466248769 3546 5603632
SGTC_2239 6685329 187.64 µM -0.61811057556953 0.254814326681836 no 2485 0.268251225758691 3551 805680
SGTC_26 0302-0163 425.158 µM -0.618238774910297 0.254771453149985 no 2486 0.268208976876177 3524 3100915
SGTC_2737 bleomycin 30.5 nM -0.618883194962712 0.254555997843561 no 2487 0.267996655005998 3559 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1977 st070720 65.3 µM -0.619342224481117 0.254402584212367 no 2488 0.267845466762519 3548 682188
SGTC_3319 9138450 16.7555 µM -0.619816591144726 0.254244095634573 no 2489 0.267689272154934 3471 2029690
SGTC_2745 rifampicin 24.3 µM -0.623214542531869 0.253110336245413 no 2490 0.266571773226662 3475 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_382 3229-0966 23.2 µM -0.62325822001435 0.253095780162081 no 2491 0.266557424196325 3588 5722370
SGTC_2017 5132927 60.65 µM -0.624811700779335 0.252578349186472 no 2492 0.266047325139193 3510 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2184 6075246 200 µM -0.625005534319383 0.252513826537367 no 2493 0.265983712904232 3545 2267320
SGTC_1315 1237-0019 3.69 µM -0.625833814543034 0.25223820931243 no 2494 0.265711974977736 3553 825140
SGTC_3219 9131112 49.47 µM -0.626859302581325 0.251897189435912 no 2495 0.265375733243764 3510 17612988 YMR079W SEC14
SGTC_3307 9126885 69.2785 µM -0.627303634032132 0.251749505285104 no 2496 0.265230110887082 3534 24824909
SGTC_2860 9025725 38.96 µM -0.62786748102654 0.251562163135631 no 2497 0.265045377696515 3470 40546248
SGTC_603 3794-0023 45.9 µM -0.62866362876188 0.251297762897848 no 2498 0.264784647168864 3556 3802260
SGTC_937 3122-0005 46.7 µM -0.630146118406133 0.25080582066124 no 2499 0.264299494166697 3568 759535
SGTC_3081 9117243 49.47 µM -0.630798991598057 0.250589336183098 no 2500 0.26408598141621 3598 45595589
SGTC_2052 5265182 7.135 µM -0.630848819757704 0.250572817863533 no 2501 0.264069689446253 3553 1239884
SGTC_250 brefeldin a 552.239 µM -0.632607282755936 0.24999024691817 no 2502 0.263495065032427 3486 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2921 7974240 10.71 µM -0.633948310435052 0.249546453962219 no 2503 0.263057278001309 3572 2979074 YDR527W RBA50
SGTC_2740 felodipine 17.08 µM -0.634069689618211 0.249506306013871 no 2504 0.263017671346647 3534 3333 L-type calcium channel blocker
SGTC_2050 5263056 171 µM -0.636249888649096 0.248785758007776 no 2505 0.262306780554856 3568 763468 YGL055W OLE1
SGTC_2738 aclarubicin 5.55 µM -0.636300310009552 0.248769107045483 no 2506 0.262290351467722 3479 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2611 pyromycin 23.93 µM -0.637082597867561 0.248510843255456 no 2507 0.262035521577455 3544 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1072 oxiconazole 14.9 nM -0.637292273891441 0.248441645292183 no 2508 0.261967241287292 3603 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1299 1079-1439 3.74 µM -0.641289182033458 0.247124538509629 no 2509 0.260667408210828 3524 323161
SGTC_687 k029-0044 34.9 µM -0.643397580711179 0.246431262571842 no 2510 0.259983076425673 3599 5829338
SGTC_1048 3161-0300 24.5 µM -0.643745452260559 0.246316976974356 no 2511 0.259870255411667 3594 2165101
SGTC_347 4534-1311 26.2 µM -0.645241393582001 0.245825842095599 no 2512 0.259385382673818 3601 2862016
SGTC_674 0498-0004 451 µM -0.645259572967239 0.245819876827231 no 2513 0.259379493147067 3546 4231473
SGTC_3278 9139605 49.47 µM -0.647479087742411 0.245092163508101 no 2514 0.258660962346184 3629 7958859
SGTC_1778 st046819 58.9 µM -0.647666649054566 0.245030720835103 no 2515 0.258600289761334 3606 671715
SGTC_230 MPP+ 141.667 µM -0.649971358510589 0.244276404585729 no 2516 0.257855361301391 3575 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2845 9003024 42.97 µM -0.650361992282622 0.24414867689696 no 2517 0.257729211060219 3648 2990173
SGTC_1120 ficusin 1.78878 µM -0.650792128443797 0.244008074564334 no 2518 0.257590341091415 3616 6199 A DNA cross-linker.
SGTC_336 4111-0029 111 µM -0.650897443380843 0.243973656016357 no 2519 0.257556345962055 3555 3131175
SGTC_994 3910-0338 138 µM -0.652176293942996 0.243555916987577 no 2520 0.257143725481534 3653 3479481
SGTC_2099 5377090 177.372 µM -0.653039480061346 0.243274174084921 no 2521 0.256865413351411 3579 2243829
SGTC_2077 5212015 200 µM -0.653336840595473 0.243177156779249 no 2522 0.256769573421744 3526 780900
SGTC_728 3030-5151 22.5 µM -0.653862516075366 0.243005700275979 no 2523 0.256600192652265 3626 3125388
SGTC_985 1493-0307 8.71 µM -0.654015089783393 0.242955948446555 no 2524 0.25655104194198 3592 3278274
SGTC_2753 fluvastatin 17.09 µM -0.65514121244626 0.242588908467812 no 2525 0.256188419967787 3595 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_543 3844-1095 191 µM -0.656046891537602 0.242293936206148 no 2526 0.255896976892034 3602 4230703
SGTC_2610 ononetin 44.17 µM -0.656303443298521 0.242210414742189 no 2527 0.255814451256297 3606 259632
SGTC_1886 st057356 49.9 µM -0.657449695697469 0.241837438343618 no 2528 0.255445903190924 3566 24207747
SGTC_98 0074-0023 107.663 µM -0.657851507929762 0.241706767405122 no 2529 0.255316776476887 3574 3563821
SGTC_2710 st078562 53.7235 µM -0.657997797275746 0.241659203045199 no 2530 0.255269773284415 3581 17250908
SGTC_1434 4073-0095 163 µM -0.658110225409323 0.241622651736725 no 2531 0.255233652872576 3611 24133745
SGTC_137 0438-0332 85.389 µM -0.659857573990662 0.241054960398579 no 2532 0.254672616170257 3635 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_539 4859-0462 2.54 µM -0.660469834818548 0.240856216357347 no 2533 0.254476185061013 3620 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.661038166845956 0.240671811714506 no 2534 0.254293918663836 3663 65057 A dermal irritant. YDR527W RBA50
SGTC_2089 5281248 129.67 µM -0.661574454816143 0.240497874785329 no 2535 0.254121991707131 3623 2737878
SGTC_1062 mesoridazine 14.2 µM -0.662193098253644 0.240297312159887 no 2536 0.253923738414701 3617 4078 A neuroleptic.
SGTC_1496 4469-0713 57.4 µM -0.66290993544037 0.240065029392714 no 2537 0.253694119064754 3603 746691
SGTC_2996 9066192 71.4286 µM -0.664665794185237 0.239496581265223 no 2538 0.25313213833549 3612 6472854
SGTC_2874 9043904 71.43 µM -0.665059811577091 0.239369121674986 no 2539 0.253006119014052 3560 4463428
SGTC_3204 9114183 49.47 µM -0.666962911872319 0.238754015017967 no 2540 0.25239791195265 3634 17027248
SGTC_115 0527-0192 112.043 µM -0.668879480479242 0.238135430193113 no 2541 0.251786180305022 3649 4233931
SGTC_438 sphingosine 6.67 µM -0.669021036874729 0.238089776811879 no 2542 0.251741029304733 3508 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_342 k048-0088 23.3 µM -0.669175529737165 0.238039956762812 no 2543 0.251691756952982 3606 6820570
SGTC_668 1682-0499 62.6 µM -0.669910383072055 0.237803063355189 no 2544 0.251457460196008 3638 682214
SGTC_3033 9090887 49.47 µM -0.670716411478584 0.237543374123488 no 2545 0.251200602964189 3627 19325384
SGTC_1002 4049-0206 172 µM -0.671485235858926 0.237295816526767 no 2546 0.250955730905466 3659 4662749
SGTC_565 1418-0001 44.5 µM -0.671531004275119 0.237281083795929 no 2547 0.250941157560985 3659 2862145
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.67270048420874 0.236904801798144 no 2548 0.250568929744581 3642 3256 An antibiotic and ribosome inhibitor.
SGTC_227 fluconazole 33.516 µM -0.676085554042197 0.235817501541537 no 2549 0.249493163954547 3607 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.677155487509728 0.235474407009975 no 2550 0.249153653234661 3620 689007
SGTC_2640 pentamidine 10.38 µM -0.677529441153419 0.235354556649012 no 2551 0.249035048441646 3653 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_485 niflumic acid 177 µM -0.677759150489171 0.235280952599086 no 2552 0.24896220770836 3649 4488 A COX2 inhibitor.
SGTC_1267 0828-0272 9.49 µM -0.678403373488372 0.235074596840546 no 2553 0.248757985369494 3674 745334
SGTC_530 4358-1714 28 µM -0.679085886902228 0.234856085109063 no 2554 0.248541722101095 3659 1564641
SGTC_520 3584-0023 682 µM -0.680511340929853 0.234400077718084 no 2555 0.248090371690545 3621 1340790
SGTC_2064 5220758 200 µM -0.682002472013205 0.233923584811599 no 2556 0.247618693875089 3687 788518
SGTC_258 haloperidol 50.781 µM -0.682350038094036 0.233812596784294 no 2557 0.247508819897557 3635 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1335 1486-0900 202 µM -0.682433689465291 0.233785888809783 no 2558 0.24748237958176 3670 X1335
SGTC_23 0213-0011 39.996 µM -0.683283660049218 0.233514608489816 no 2559 0.24721380860953 3671 627608
SGTC_2679 rapamycin 1 nM -0.683347597091523 0.233494209127344 no 2560 0.247193612293202 3647 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_610 4215-0184 155 µM -0.68341060462189 0.233474107296286 no 2561 0.247173710452643 3668 5605015
SGTC_831 k061-1017 217 µM -0.684049884105648 0.233270206785491 no 2562 0.246971833236901 3694 1240153
SGTC_3186 9110464 49.47 µM -0.684100084380763 0.233254199411611 no 2563 0.24695598429594 3655 17018021
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.686062671560003 0.232628866794301 no 2564 0.24633679439913 3649 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3157 9099274 49.47 µM -0.686288433801255 0.232556992738803 no 2565 0.246265620551899 3635 17217662
SGTC_2803 7707263 71.43 µM -0.686482995223422 0.232495061736175 no 2566 0.246204291926891 3647 2199229
SGTC_3086 9117350 49.47 µM -0.687031215060938 0.232320606777643 no 2567 0.246031529020834 3587 2679265
SGTC_146 3448-8650 53.125 µM -0.687064565699076 0.232309996261146 no 2568 0.246021021187911 3666 2891488 YIL048W NEO1
SGTC_1912 st060209 90.8 µM -0.68889717142441 0.231727366763 no 2569 0.245443989789304 3651 688787
SGTC_784 4579-0127 173 µM -0.689059616435553 0.231675760893933 no 2570 0.245392875944086 3742 1948547
SGTC_1316 1272-0050 65.9 µM -0.690361060226252 0.231262546791897 no 2571 0.244983579052173 3659 7340392
SGTC_73 0327-0325 16.231 µM -0.690702191929992 0.231154304028168 no 2572 0.244876355799793 3686 53298
SGTC_2329 6138490 200 µM -0.691500319173893 0.23090116481576 no 2573 0.244625590104452 3657 720019
SGTC_1671 st016596 74.5 µM -0.69482105429369 0.229849602400842 no 2574 0.243583725976578 3710 2829167
SGTC_2620 irigenin 100 µM -0.695166842973559 0.229740257380555 no 2575 0.243475374429484 3689 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1334 1486-0610 236 µM -0.695724813260619 0.229563877905247 no 2576 0.24330059151379 3678 3742339
SGTC_3136 9095672 49.47 µM -0.696094351677978 0.22944710522937 no 2577 0.243184871789614 3496 17217380
SGTC_135 0933-0004 26.348 µM -0.696304004351674 0.22938087061828 no 2578 0.243119232985658 3649 21230617 YGL099W LSG1
SGTC_2898 9056270 58.44 µM -0.69757710330417 0.228978896499618 no 2579 0.242720852440712 3620 19154699
SGTC_3270 9137563 49.47 µM -0.698394591323355 0.22872098760026 no 2580 0.242465228961312 3658 17015724
SGTC_2140 5586273 200 µM -0.698493347193804 0.228689842204071 no 2581 0.242434358483176 3660 854421
SGTC_1534 6-azauridine 81.6 µM -0.699752924089187 0.228292808729299 no 2582 0.242040809319368 3712 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1234 0326-0494 15.5 µM -0.703793937822694 0.227021652462933 no 2583 0.24078055475986 3707 1547813
SGTC_184 1494-0393 24.714 µM -0.703925526533465 0.226980326636433 no 2584 0.240739576837775 3671 3090647
SGTC_525 k781-2675 26.7 µM -0.704938866995041 0.226662226207307 no 2585 0.240424140580162 3717 3651118 YDL195W SEC31
SGTC_3303 9125618 40.5795 µM -0.705096388071261 0.226612800947705 no 2586 0.24037512707845 3704 22695467
SGTC_3272 9137413 49.47 µM -0.706694912708701 0.226111577414245 no 2587 0.239878045845168 3642 17614870
SGTC_1677 st019204 53.9 µM -0.706835394774438 0.226067558693893 no 2588 0.239834388008091 3668 3945625
SGTC_1164 k060-0068 93.7 µM -0.708884437414657 0.225426061463037 no 2589 0.239198096688979 3709 5963676
SGTC_1217 1183-1422 255 µM -0.709564423027741 0.22521340518084 no 2590 0.238987144091503 3736 2849664
SGTC_2262 9014885 67.46 µM -0.709856787369041 0.225122007139313 no 2591 0.238896474896607 3628 6457424
SGTC_1408 3909-7976 48.8 µM -0.711300178070038 0.224671086874648 no 2592 0.238449120635148 3742 24152374
SGTC_636 0kpi-0074 126 µM -0.711674070696311 0.22455436511306 no 2593 0.238333313849606 3711 616434
SGTC_3291 9121177 71.43 µM -0.712892216848959 0.22417432310402 no 2594 0.237956227866659 3668 17015612
SGTC_2232 chlorophetanol 41.5365 µM -0.713277300998951 0.22405425907069 no 2595 0.237837090352291 3758 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_683 panaxydol 45 µM -0.713921545670987 0.223853473988812 no 2596 0.237637846797602 3673 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1314 1222-0010 41.1 µM -0.715137620790568 0.223474751256126 no 2597 0.237262004734363 3718 3526027
SGTC_220 paclitaxel 373.376 µM -0.717020552788289 0.222889068772408 no 2598 0.23668070752166 3650 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1105 epirubicin 18.1 µM -0.717196262495089 0.222834459240388 no 2599 0.236626502558682 3699 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2541 muurolladie-3-one 83.07 µM -0.717853987536378 0.222630109899733 no 2600 0.236423660573229 3726 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2402 5553605 200 µM -0.718585488748982 0.222402964482174 no 2601 0.236198178527031 3727 6758546
SGTC_497 capsazepine 133 µM -0.721066143488142 0.221633657696767 no 2602 0.235434410164712 3708 2733484 A calcium channel blocker.
SGTC_301 4119-0100 24.5 µM -0.721713563982023 0.22143312857041 no 2603 0.235235300491507 3734 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2142 5622915 118.518 µM -0.722017179847278 0.22133912369296 no 2604 0.235141957577564 3714 5322196
SGTC_1746 st038117 42 µM -0.72245078880038 0.221204910220206 no 2605 0.23500868538504 3763 2898218
SGTC_1850 st056238 17 µM -0.722522886649649 0.221182598538373 no 2606 0.234986529745621 3716 5393177
SGTC_516 3992-2719 87.3 µM -0.723072587445205 0.221012528319148 no 2607 0.234817644865759 3687 5350887 YDR037W KRS1
SGTC_1438 4092-1045 4 µM -0.726615567468812 0.219918174079347 no 2608 0.233730744506797 3709 1351342
SGTC_1564 D-Arginine 115 µM -0.729197076344261 0.219122760770917 no 2609 0.232940559683277 3705 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1634 st006576 41 µM -0.729604099003289 0.218997500275936 no 2610 0.232816107980381 3696 3915356
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.730534939067548 0.218711190752247 no 2611 0.232531632185071 3759 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_998 3996-0085 177 µM -0.730571055431421 0.218700086356913 no 2612 0.232520598491078 3755 715391
SGTC_879 0831-1030 162 µM -0.731084923098885 0.218542126934889 no 2613 0.232363641400004 3756 1549252
SGTC_815 1582-0027 36.9 µM -0.731601492420689 0.218383403272038 no 2614 0.232205918529012 3759 3128206
SGTC_2629 bisabolol 100 µM -0.731823037425685 0.218315350601112 no 2615 0.232138292983882 3732 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2812 7970281 58.44 µM -0.732690215751767 0.218049094256118 no 2616 0.231873696435732 3748 2233435
SGTC_1404 3909-7820 48.3 µM -0.733352873791375 0.217845759564622 no 2617 0.231671617125441 3689 23741373
SGTC_1274 0865-0114 173 µM -0.733503869296148 0.217799442336574 no 2618 0.231625584382566 3747 870624
SGTC_2505 galangin 7.89 µM -0.733714770281303 0.217734758866252 no 2619 0.231561297287803 3658 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1117 retinoic acid 1.10837 µM -0.734850843880501 0.217386515043549 no 2620 0.231215169094666 3738 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_819 1013-0258 27.7 µM -0.735827395016576 0.217087427284764 no 2621 0.230917873547032 3761 5753198
SGTC_2092 5303694 80.6725 µM -0.739039422706033 0.21610536017314 no 2622 0.229941529579484 3737 1963699
SGTC_2696 st077691 74.316 µM -0.739046090935604 0.216103324063531 no 2623 0.229939505077449 3724 757133
SGTC_854 0422-0053 192 µM -0.740638246094759 0.215617485798903 no 2624 0.229456405872773 3779 3596728
SGTC_973 1325-0077 65.9 µM -0.74176414993038 0.21527430444163 no 2625 0.22911512246616 3766 2835149
SGTC_1086 cerivastatin 2.18 µM -0.742164845242064 0.215152246942863 no 2626 0.228993732633642 3688 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3100 9120536 49.47 µM -0.747413060392542 0.213557278675501 no 2627 0.22740713207958 3618 16421196
SGTC_1973 st070275 50.2 µM -0.747799860441816 0.213440000746922 no 2628 0.227290443153197 3671 17118334
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.748335006936408 0.213277806028571 no 2629 0.227129057066227 3751 688669
SGTC_3129 9127257 49.47 µM -0.749903126804861 0.212802946915276 no 2630 0.226656525581826 3754 837894
SGTC_1898 st060199 18.6 µM -0.750120169597677 0.212737270528308 no 2631 0.226591166443581 3758 688866
SGTC_1613 st002381 52.1 µM -0.752153167446538 0.212122667319537 no 2632 0.22597947682183 3723 551167
SGTC_2647 atorvastatin 60.16 µM -0.752444404723413 0.212034707378111 no 2633 0.225891925684186 3743 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_447 ml7 120 µM -0.753178469703233 0.211813098574486 no 2634 0.225671337734505 3774 4216 Selective myosin light chain kinase inhibitor.
SGTC_1723 st034307 2.5525 µM -0.753343723466662 0.211763228376823 no 2635 0.225621695469937 3819 867466
SGTC_100 0086-0128 49.5915 µM -0.753860877247026 0.211607206372147 no 2636 0.225466382300549 3763 93297
SGTC_290 2043-6722 48.1 µM -0.753991135511945 0.211567918894377 no 2637 0.225427272292764 3758 773758 YLR208W SEC13
SGTC_1783 st039459 87.517 µM -0.754158053560512 0.211517580622543 no 2638 0.225377160809732 3863 729761
SGTC_14 0354-0009 295 µM -0.756048051333788 0.210948094406511 no 2639 0.224810193287084 3821 1713507
SGTC_74 000s-0487 160.283 µM -0.757177464045382 0.21060821402953 no 2640 0.224471774865393 3699 677548
SGTC_1893 st059353 36.1 µM -0.757746475311303 0.21043710013514 no 2641 0.224301385299971 3794 3112488
SGTC_1888 azatryptophan 97.5 µM -0.75818052075204 0.210306628245798 no 2642 0.224171460429745 3788 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2671 danthron 100 µM -0.758746592896681 0.210136541177762 no 2643 0.224002079616681 3748 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1964 st076914 61 µM -0.759098356195266 0.210030887970576 no 2644 0.22389686120451 3815 24208661
SGTC_287 k060-0039 29.6 µM -0.760133066461655 0.209720290493909 no 2645 0.223587524555101 3795 5861974
SGTC_3008 9078912 71.4286 µM -0.760417314315457 0.209635012792293 no 2646 0.223502588484322 3757 16648731
SGTC_3060 1327-0027 12.5 µM -0.760981897935355 0.209465691554072 no 2647 0.223333939756303 3711 16000455 YPR107C YTH1
SGTC_1228 0124-0032 52.5 µM -0.761286268464167 0.209374442815904 no 2648 0.223243050234498 3840 X1228
SGTC_2193 5925765 200 µM -0.762188469342017 0.209104105043361 no 2649 0.222973763499584 3759 877370
SGTC_1382 3002-2117 298 µM -0.763606814107762 0.208679524397892 no 2650 0.222550793675497 3812 1497314
SGTC_2212 7123476 200 µM -0.764099946261916 0.208532024717169 no 2651 0.222403842165463 3737 1085715
SGTC_2401 5128683 200 µM -0.766250153018322 0.207889599830683 no 2652 0.221763735875317 3757 708373
SGTC_1996 st072960 66.8 µM -0.76940780094172 0.206948299447517 no 2653 0.220825629519109 3751 1719405
SGTC_262 fenpropimorph 62.5 µM -0.769851727087317 0.206816166807607 no 2654 0.220693925821222 3724 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1402 3909-7673 35.9 µM -0.769897803452501 0.206802455244095 no 2655 0.2206802584952 3789 5328014
SGTC_3178 9107506 49.47 µM -0.769998399223386 0.206772521478057 no 2656 0.22065042112489 3802 8897194
SGTC_964 1287-0107 19.4 µM -0.771491219246376 0.206328612259263 no 2657 0.220207912528263 3797 51516812 YPR165W RHO1
SGTC_1740 st038286 13.222 µM -0.772151643580992 0.206132406932796 no 2658 0.220012308987769 3817 716786
SGTC_708 3448-5400 146 µM -0.772154297891168 0.206131618587608 no 2659 0.220011523039134 3754 3462195
SGTC_2302 7771753 200 µM -0.772193306267553 0.20612003308458 no 2660 0.219999972736039 3797 2203047
SGTC_3261 9137475 49.47 µM -0.774536340918451 0.205424859170236 no 2661 0.219306843113513 3695 17027690
SGTC_2906 7926292 26.41 µM -0.774780425972367 0.205352519767675 no 2662 0.219234708759619 3761 2966319
SGTC_3200 9114385 49.47 µM -0.778397600371444 0.204282273675425 no 2663 0.218167326493134 3816 17018030 YLR208W SEC13
SGTC_900 1112-0045 141 µM -0.778727324168949 0.20418488076193 no 2664 0.218070178352363 3723 56211 YIL048W NEO1
SGTC_3266 9136860 49.47 µM -0.77900983170533 0.204101456459656 no 2665 0.217986961609633 3721 4871271 YPR165W RHO1
SGTC_3153 9100258 49.47 µM -0.780468723208397 0.203670969944643 no 2666 0.217557515207004 3740 25236848
SGTC_1178 0988-0033 191 µM -0.780972979533748 0.20352230108531 no 2667 0.217409193492743 3845 5392207
SGTC_154 3389-1638 511.116 µM -0.78268004846419 0.203019490134642 no 2668 0.216907510629453 3759 5238686
SGTC_2523 spermine 47.74 µM -0.783224944418873 0.202859149321471 no 2669 0.216747514596039 3791 1103 A DNA binding polyamine.
SGTC_303 1348-1668 34.2 µM -0.783740408581258 0.202707538742711 no 2670 0.216596223360523 3812 5380509
SGTC_1350 1495-0454 146 µM -0.785832042697627 0.202093033312125 no 2671 0.215982945814568 3813 1069057
SGTC_2870 9038528 12.99 µM -0.789776171262787 0.200937317080473 no 2672 0.214829248779194 3832 6463316
SGTC_3230 9131665 49.47 µM -0.789939559088565 0.200889526553791 no 2673 0.214781533559565 3740 15943720
SGTC_333 3486-0131 40.1 µM -0.793386984371361 0.199882754271281 no 2674 0.213776195792543 3883 6744690
SGTC_3068 9116768 49.47 µM -0.794167977304134 0.199655098503134 no 2675 0.21354882407198 3774 41904888
SGTC_2288 7946289 167.31 µM -0.797433390608843 0.198704936999353 no 2676 0.212599686683747 3843 1246052
SGTC_3329 9141233 27.5565 µM -0.798209926167834 0.198479384639101 no 2677 0.21237433906237 3809 4909101 YNL103W MET4
SGTC_1032 k061-1018 98.7 µM -0.798596363024096 0.198367197850591 no 2678 0.212262248610047 3965 4005393
SGTC_2295 7971645 200 µM -0.799147445688439 0.198207278817474 no 2679 0.212102460579733 3877 2978226 YKL099C UTP11
SGTC_2744 captopril 92.04 µM -0.80021510592064 0.197897675339316 no 2680 0.211793089577087 3781 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1275 0867-0008 21.1 µM -0.80078385866414 0.19773286595697 no 2681 0.211628392556782 3809 3422836
SGTC_3168 9103419 49.47 µM -0.802595276401471 0.197208518395941 no 2682 0.211104349717911 3767 16649256
SGTC_849 0386-0493 241 µM -0.8028159003599 0.197144712328583 no 2683 0.211040575242272 3796 726119
SGTC_1663 st014140 55.4 µM -0.803372092694793 0.196983912874871 no 2684 0.210879850112236 3893 4207120
SGTC_2612 dictamnine 15.46 µM -0.805586286549574 0.196344560027714 no 2685 0.210240717681655 3837 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1988 st071872 53.4 µM -0.806408338633282 0.196107511426699 no 2686 0.210003720232457 3850 16414116
SGTC_2062 5245942 200 µM -0.806557389096105 0.196064549530082 no 2687 0.2099607658325 3904 1376160
SGTC_2010 4012422 159 µM -0.806617591678303 0.196047198521584 no 2688 0.209943417697254 3846 952393
SGTC_2350 9023895 38.85 µM -0.806809952160719 0.195991764478552 no 2689 0.209887992238325 3869 2997209
SGTC_2400 5203494 178.7 µM -0.809158193387917 0.19531582003744 no 2690 0.209212079373815 3776 6777674
SGTC_2407 paclitaxel 400 µM -0.811706990720471 0.194583750417749 no 2691 0.208479891035702 4027 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3265 9137266 49.47 µM -0.811878978040854 0.194534412157292 no 2692 0.20843053903545 3749 17224265
SGTC_1454 4239-0054 42.6 µM -0.814388086840204 0.19381548642528 no 2693 0.207711330597006 3994 1340767
SGTC_433 pimozide 108 µM -0.814901187383412 0.193668669316693 no 2694 0.207564436729342 3775 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_64 000l-0018 272.079 µM -0.815789952027997 0.193414521286991 no 2695 0.207310140532871 3784 6811119
SGTC_996 3970-0799 1.8 µM -0.816061801405183 0.193336824846044 no 2696 0.207232394921802 3893 6615648 YGL040C HEM2
SGTC_2236 dapsone 200 µM -0.817318516914283 0.192977894414006 no 2697 0.206873213758441 3859 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.817357382192452 0.19296680059552 no 2698 0.206862111572008 3852 77254
SGTC_3297 9117502 71.43 µM -0.818632398335627 0.19260307227174 no 2699 0.206498088320647 3872 7453720
SGTC_1567 st069303 68.4 µM -0.819184293196703 0.192445761322411 no 2700 0.206340637433453 3943 5581319
SGTC_2964 9083345 53.42 µM -0.824788638575291 0.190852763287987 no 2701 0.204745799017349 3869 17741579
SGTC_2310 7668677 200 µM -0.825387362478458 0.190683059613325 no 2702 0.204575853666467 3844 2197143
SGTC_2263 7948595 193.29 µM -0.825405013743275 0.190678057904262 no 2703 0.204570844700626 3851 2971371
SGTC_943 3253-1379 105 µM -0.825678646545134 0.190600530890325 no 2704 0.204493204225526 3827 668464
SGTC_1812 st052057 4.327 µM -0.826356315259054 0.190408613718387 no 2705 0.204300998253627 3884 3645418
SGTC_559 1550-0661 158 µM -0.828218047058802 0.189881978615422 no 2706 0.203773512535776 3933 5830875
SGTC_1631 benzylvanillin 81.9 µM -0.828458689187177 0.189813972687002 no 2707 0.203705390541904 3947 75506
SGTC_738 1315-0003 72.4 µM -0.828650243977081 0.189759849642339 no 2708 0.203651174106912 3887 6251474
SGTC_510 ag-490 170 µM -0.830032826462266 0.18936948798025 no 2709 0.20326011209474 3997 5328779
SGTC_2358 9037157 4 µM -0.830401660227471 0.189265434143854 no 2710 0.203155863626108 3881 2388925
SGTC_1140 3229-1848 2.98 µM -0.830897678847708 0.189125554960858 no 2711 0.203015717519971 3904 2849525
SGTC_2119 5528445 120.635 µM -0.83127994411336 0.189017798117253 no 2712 0.202907750917929 3897 791935
SGTC_277 nystatin 15.5 µM -0.833855069732377 0.188292881261616 no 2713 0.202181329253503 3856 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2739 tacrine 100.86 µM -0.835586999866766 0.187806296230494 no 2714 0.201693642365918 3923 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2186 6124449 200 µM -0.836359967681473 0.187589382118412 no 2715 0.201476213218737 3868 3834182 YLR033W RSC58
SGTC_2452 5863136 48.41 µM -0.836621989017772 0.187515887519365 no 2716 0.20140254077554 3856 2184096
SGTC_332 4112-0506 40.9 µM -0.837085926515649 0.187385800928696 no 2717 0.201272135248862 3860 2790355
SGTC_1405 3909-7894 12 µM -0.839429375164043 0.186729558350608 no 2718 0.200614202738036 3902 7104060
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.840841729297483 0.186334740754191 no 2719 0.200218303092565 3862 390807
SGTC_581 0958-0271 211 µM -0.842165795674069 0.185965073709301 no 2720 0.199847578287162 3899 4591145
SGTC_2035 5154463 94.595 µM -0.842204446973514 0.185954289460351 no 2721 0.199836762531023 3911 2769623
SGTC_7 0192-1582 4.227 µM -0.842500572852621 0.185871679097163 no 2722 0.199753909591655 3934 252616
SGTC_580 1123-0028 41 µM -0.842746449252186 0.185803104149908 no 2723 0.199685131638569 3955 1677248 YPR107C YTH1
SGTC_476 mead acid 10 µM -0.843256079250529 0.185661018281824 no 2724 0.199542620399555 3899 5312531 An omega 9 fatty acid.
SGTC_3202 9113761 49.47 µM -0.84348936091016 0.185596001384098 no 2725 0.199477406719952 3942 4798415
SGTC_3271 9137798 49.47 µM -0.845195476435296 0.185120927104304 no 2726 0.199000853781856 3798 6498326
SGTC_2820 7989630 71.43 µM -0.845523216288167 0.185029753273765 no 2727 0.198909387955921 3827 2984098
SGTC_1755 st041960 45.185 µM -0.845599452044589 0.185008549276471 no 2728 0.198888115670345 3961 2257073
SGTC_3315 9136395 68.55 µM -0.8458033411554 0.184951847555429 no 2729 0.198831230634746 3883 16876844
SGTC_2692 st077426 47.7 µM -0.847190508468429 0.184566361952127 no 2730 0.198444471555592 3903 25238571
SGTC_1785 bathophenanthroline 24 µM -0.84807106616958 0.184321919620385 no 2731 0.198199197068243 3842 72812 An iron chelator.
SGTC_2584 androsterone 48.74 µM -0.848140178804434 0.184302742520452 no 2732 0.198179953873928 3889 2754130 A steroid.
SGTC_1520 flindersine 88 µM -0.848199553629712 0.18428626842079 no 2733 0.19816342290171 4040 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_425 3825-7017 13.1 µM -0.849107689902588 0.184034411730488 no 2734 0.197910685902327 4000 3397440
SGTC_792 4534-1957 155 µM -0.849857548181515 0.183826612454128 no 2735 0.197702144972627 3863 1717904
SGTC_3215 9129942 49.47 µM -0.851662175244395 0.183327117077674 no 2736 0.19720080999573 3867 17682944
SGTC_3226 9131256 49.47 µM -0.852943370364828 0.182973014484559 no 2737 0.196845354501646 3798 17178073
SGTC_2315 7733312 200 µM -0.853604335517658 0.18279050089832 no 2738 0.196662127753383 3842 726316
SGTC_2176 5809774 33.9695 µM -0.855349220704018 0.182309228634452 no 2739 0.196178923143409 3898 2870539
SGTC_2443 5493264 126.67 µM -0.855356498717591 0.182307222880629 no 2740 0.196176909178897 3936 5340055
SGTC_1030 k029-0042 36.7 µM -0.857934243398597 0.181597687571817 no 2741 0.195464387108115 3903 6080581
SGTC_1617 st002906 78 µM -0.860468538493391 0.180901799131975 no 2742 0.19476540951235 3904 5150859
SGTC_1135 dihydrocapsaicin 536.708 nM -0.861538382828299 0.180608534469723 no 2743 0.194470795398824 3840 107982 A Capsaicinoid.
SGTC_2237 6667747 47.222 µM -0.861597596247966 0.180592311658314 no 2744 0.194454497112541 3910 729940 YDL015C TSC13
SGTC_561 1550-0330 72.9 µM -0.863168733015693 0.180162198232384 no 2745 0.194022350992741 3866 6812934
SGTC_2825 7998094 58.44 µM -0.867195493438419 0.179062773770912 no 2746 0.192917452532307 3931 2987815
SGTC_160 3453-0671 289.699 µM -0.868076761924523 0.178822725617417 no 2747 0.192676155767592 3981 5322268
SGTC_22 0964-0034 14.468 µM -0.869321949213912 0.178483895344747 no 2748 0.192335530348224 3970 138402
SGTC_3105 9121040 49.47 µM -0.87008709431469 0.178275890998211 no 2749 0.192126404968867 3751 41448907
SGTC_1770 st043884 66.3 µM -0.871650894212158 0.17785124809235 no 2750 0.19169942845472 3924 670149
SGTC_2927 9011802 47.9 µM -0.872074499928225 0.177736329749686 no 2751 0.191583868175551 3957 43912568
SGTC_953 1188-0045 9.7 µM -0.872121512759718 0.177723578710691 no 2752 0.191571045635351 3978 6144426
SGTC_2775 cyproheptadine 69.59 µM -0.873035123471501 0.177475899555872 no 2753 0.191321966773268 3940 2913 A selective serotonin reuptake inhibitor.
SGTC_1698 5-fluorocytosine 1.055 µM -0.873361572853509 0.177387452243468 no 2754 0.191233014613663 3968 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3334 9142812 21.919 µM -0.87424494234095 0.177148254075256 no 2755 0.190992437915191 3970 45283678
SGTC_1629 st005085 44.9 µM -0.8748048594834 0.176996745653327 no 2756 0.190840046337774 3918 24207091
SGTC_3179 9107801 49.47 µM -0.875758443218488 0.17673890320253 no 2757 0.190580683055503 3934 4818259
SGTC_1670 st016595 4.04 µM -0.880129800266423 0.175559959998169 no 2758 0.189394498568991 3945 597879
SGTC_2985 9022375 71.43 µM -0.880316844709918 0.175509626055712 no 2759 0.189343844925027 4013 4939335
SGTC_1305 1181-0477 144 µM -0.880382410904367 0.175491984258955 no 2760 0.189326090869544 4000 6252086
SGTC_405 ebelactone b 50 µM -0.880502549289882 0.17545966172201 no 2761 0.189293562380958 3907 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2763 lisinopril 49.32 µM -0.881311526797696 0.175242109276826 no 2762 0.189074614444153 3845 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.881718618596116 0.175132697763737 no 2763 0.188964494985696 3940 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_304 1310-0298 97 µM -0.881928846922958 0.175076212982443 no 2764 0.188907643114782 3818 1550234
SGTC_1719 st032227 49.2 µM -0.882218901492595 0.174998299220287 no 2765 0.188829221202424 3942 3125804
SGTC_886 0866-0150 153 µM -0.8826974701033 0.174869795370983 no 2766 0.188699874705319 4011 271463
SGTC_1281 0884-0031 11.8 µM -0.882844457912017 0.174830338657386 no 2767 0.188660158121513 3955 1548255
SGTC_202 3594-0513 34.79 µM -0.884643157451674 0.17434796196759 no 2768 0.188174561111089 3941 708429
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.888749938490521 0.173249774963639 no 2769 0.187068742979164 3966 229346 A bile salt which induces apoptosis.
SGTC_584 0986-0246 15.4 µM -0.889929962165199 0.172935043346826 no 2770 0.186751747199132 4037 53315 YDR232W HEM1
SGTC_3069 9117009 49.47 µM -0.890114623469804 0.17288582414257 no 2771 0.186702170795522 3919 41904981
SGTC_1147 3809-1045 12.3 µM -0.890607470759837 0.172754505457067 no 2772 0.186569894955794 3931 325925
SGTC_3021 9087658 49.47 µM -0.891223593152219 0.172590429686961 no 2773 0.186404614815579 3906 25237042
SGTC_1401 3807-4679 7.6 µM -0.892503776490299 0.172249829761967 no 2774 0.186061484735938 3895 3291456
SGTC_1938 st074717 56.4 µM -0.893780209983559 0.171910654813088 no 2775 0.18571974984031 3803 17250979
SGTC_1088 bifonazole 369 nM -0.894551294187078 0.171705968448227 no 2776 0.185513499052125 3908 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2923 7992654 58.14 µM -0.89488074357341 0.171618562713153 no 2777 0.185425420784561 3980 2985126
SGTC_1662 st014054 52 µM -0.895077392467554 0.171566403632946 no 2778 0.185372859092018 3979 2838777
SGTC_1116 jasmonic acid 1.58368 µM -0.896469437342436 0.171197467843485 no 2779 0.185001048143014 4033 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3301 9125354 19.7965 µM -0.896572536505489 0.171170163506593 no 2780 0.184973529112063 3935 41905162
SGTC_1436 4092-1007 8.32 µM -0.897740942619468 0.170860922507817 no 2781 0.184661838162288 3947 2881121
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.897915919318275 0.170814642377932 no 2782 0.184615188469761 3965 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_84 0443-0269 128.823 µM -0.899737210175267 0.170333399898595 no 2783 0.184130058111742 3843 6150058
SGTC_2083 5306046 65.942 µM -0.899912282932204 0.1702871859541 no 2784 0.18408346648596 3985 539837
SGTC_3183 9108214 49.47 µM -0.90174841174508 0.169802987109946 no 2785 0.1835952648489 3918 4974831
SGTC_117 lucigenin 22.078 µM -0.901750892139212 0.169802333611951 no 2786 0.183594605892085 4012 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_697 0508-1955 564 µM -0.903828152838368 0.169255613607452 no 2787 0.183043265546391 3967 6243113
SGTC_217 ketoconazole 989 nM -0.906603226610496 0.168526999572319 no 2788 0.182308327432584 3858 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1930 st074634 34.3 µM -0.907838819328492 0.168203236289992 no 2789 0.181981692696737 3899 684253 YOR116C RPO31
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.909048728755416 0.167886590847533 no 2790 0.181662202307463 3921 279621
SGTC_398 bronopol 33.3 µM -0.909599019032998 0.167742701395175 no 2791 0.181517008068184 3877 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1063 disulfiram 1.84 µM -0.909719878587674 0.167711109776492 no 2792 0.181485128972841 3962 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1573 oleylamine 1.06 µM -0.911222172302101 0.167318743329886 no 2793 0.181089161895917 3981 5356789 An amine of the fatty acid oleic acid.
SGTC_3150 9097574 49.47 µM -0.912552492812414 0.166971786854284 no 2794 0.180738974867693 4016 17217476
SGTC_1398 3558-0053 112 µM -0.918122187581242 0.165524215492415 no 2795 0.179277450048652 3888 4532369
SGTC_2784 7567673 72.73 µM -0.918371855325782 0.165459517155825 no 2796 0.179212110095951 3966 3471247
SGTC_3351 9150312 21.596 µM -0.920620390954499 0.164877573940958 no 2797 0.17862432621811 3909 4904905
SGTC_2600 tangeritin 87.95 µM -0.920937588058749 0.164795587017569 no 2798 0.178541506360983 3933 68077 A bioactive flavone.
SGTC_1773 st048542 73.5835 µM -0.922874996197194 0.164295392466563 no 2799 0.178036176106261 3936 3237138
SGTC_1106 tegaserod maleate 11.7 µM -0.923066570885597 0.16424598579423 no 2800 0.177986257106686 3991 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_913 3487-1245 167 µM -0.923169340789014 0.164219485643027 no 2801 0.177959481785062 3939 4016153
SGTC_1933 st074711 15.9 µM -0.923175008512857 0.164218024249736 no 2802 0.177958005209447 3970 17250958
SGTC_1201 1889-3372 45.9 µM -0.924740166212493 0.163814779183265 no 2803 0.177550540427336 3874 5392199
SGTC_575 k072-0246 11.9 µM -0.926628785313705 0.163329054311225 no 2804 0.177059652043434 4048 6796779
SGTC_1324 1418-0026 34.4 µM -0.930614393596795 0.162307088829841 no 2805 0.176026533137136 4044 1372513
SGTC_1399 3562-5772 25 µM -0.930843020922064 0.162248592111241 no 2806 0.175967386083315 3941 23847490
SGTC_1762 st045503 25.4615 µM -0.932455229050509 0.161836481331473 no 2807 0.175550656957178 4098 4645554
SGTC_2116 5511452 16.8835 µM -0.934605772250696 0.1612878245948 no 2808 0.174995751592747 4050 870744
SGTC_1522 st012842 45.6 µM -0.934655286936882 0.161275206480027 no 2809 0.174982988422876 3876 3491067 YOR116C RPO31
SGTC_673 1082-0474 110 µM -0.934681924481415 0.161268418546394 no 2810 0.174976122431529 4019 3098046
SGTC_3195 9113082 49.47 µM -0.935634433429155 0.161025817172194 no 2811 0.174730719726997 3946 17018038
SGTC_3246 9135460 32.98 µM -0.936523413980385 0.160799611295264 no 2812 0.174501881586141 3952 41446951
SGTC_2837 9008476 45.46 µM -0.936889613636336 0.160706490191305 no 2813 0.17440767118299 4030 2992805
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.937952445918011 0.160436421479734 no 2814 0.174134424508941 3970 756377
SGTC_2130 NSC 7 2.4545 µM -0.938162163470115 0.160383166701951 no 2815 0.174080539767454 4077 21448
SGTC_3075 9116269 49.47 µM -0.938650529723477 0.160259197840135 no 2816 0.173955100229463 4037 17015205 YNL244C SUI1
SGTC_2391 6285546 200 µM -0.940328953480827 0.159833617619148 no 2817 0.173524426257612 4004 846083
SGTC_3142 9086498 49.47 µM -0.941182689168313 0.15961742878529 no 2818 0.173305623132791 3947 25236367
SGTC_3097 9117246 49.47 µM -0.941423458046298 0.159556494241723 no 2819 0.173243948470353 4040 16423892
SGTC_2313 7726885 200 µM -0.941571181116829 0.159519115560715 no 2820 0.173206115072968 4070 726423
SGTC_3073 9114972 49.47 µM -0.942818835301157 0.159203647639758 no 2821 0.172886787912894 4015 41905075
SGTC_175 3793-3120 23.7 µM -0.944985765272313 0.158656713709895 no 2822 0.172333071672431 4038 5322297
SGTC_1606 st000094 49.2 µM -0.946478677866952 0.158280619642752 no 2823 0.171952246276414 4062 1242210
SGTC_2709 st078560 56 µM -0.949150247053594 0.157609060040346 no 2824 0.17127210087695 4011 17250903
SGTC_2000 st075254 36.4 µM -0.949214719260852 0.157592876654678 no 2825 0.171255708408158 3948 17234175
SGTC_2552 juarezic acid 87.02 µM -0.951177065791381 0.157100823823278 no 2826 0.170757249288309 4023 1549512
SGTC_968 1309-0633 340 µM -0.951222232550753 0.157089510295075 no 2827 0.170745787342541 4081 3761976
SGTC_3283 9109332 35.8195 µM -0.951311012930472 0.157067273836206 no 2828 0.170723259025581 3871 17027281
SGTC_1761 st044296 37 µM -0.951427784685133 0.157038029644465 no 2829 0.170693630701013 4021 1826700
SGTC_21 0849-0113 22.993 µM -0.953108027341835 0.156617628047999 no 2830 0.170267669666459 3988 1560156
SGTC_1863 st057641 20.1 µM -0.95324903234048 0.156582381914533 no 2831 0.170231954259864 4046 3921635
SGTC_2932 9016711 44.54 µM -0.953693037767882 0.156471430780964 no 2832 0.170119522692671 4062 7117328
SGTC_1693 xanthone 101.9 µM -0.954371275051002 0.15630204814021 no 2833 0.16994787055231 4077 7020 An insecticide.
SGTC_813 k007-0158 173 µM -0.955555008561429 0.156006712582 no 2834 0.169648550660127 4025 6523916
SGTC_2189 6047310 154.431 µM -0.957600918306299 0.155497136124603 no 2835 0.169132017966746 4012 711535
SGTC_2167 5876490 200 µM -0.958855216722332 0.155185270556478 no 2836 0.168815843993307 4192 686534
SGTC_2012 4023501 200 µM -0.9620680554557 0.154388323112358 no 2837 0.168007709641089 4066 3477460
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.963671110811996 0.153991697510867 no 2838 0.167605421248112 4082 23665772 A membrane-active detergent.
SGTC_1877 wortmannin 25 µM -0.967778464690199 0.152978541349739 no 2839 0.166577510612922 4054 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2754 granisetron 64.02 µM -0.967781263967168 0.152977852365769 no 2840 0.166576811453372 4068 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1368 1852-0141 284 µM -0.968230058912309 0.152867417402256 no 2841 0.166464742977401 4061 2838987
SGTC_2289 7946404 165.07 µM -0.968798967505241 0.152727502075506 no 2842 0.166322750928707 4083 1246120 YPR165W RHO1
SGTC_2856 9022925 19.48 µM -0.968915356620294 0.152698888226119 no 2843 0.166293711387704 4116 4944862
SGTC_1256 0570-0116 285 µM -0.969966795944673 0.152440556785535 no 2844 0.166031521565558 4066 410638
SGTC_2385 9074692 200 µM -0.970915561583976 0.152207700649402 no 2845 0.165795164125299 4075 17046906
SGTC_219 mitoxanthrone 164.414 µM -0.971666353421762 0.15202360081851 no 2846 0.165608280362047 4013 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_18 0111-0177 500 nM -0.971917449046527 0.15196206329083 no 2847 0.165545809167783 4101 721752
SGTC_3263 9137018 49.47 µM -0.972258002369938 0.151878628265433 no 2848 0.165461105753607 4050 43844957
SGTC_2862 9027634 71.43 µM -0.972703072955417 0.151769632564016 no 2849 0.165350448772431 3996 5012562
SGTC_1094 duloxetine 25.4 µM -0.972983376249749 0.151701014283345 no 2850 0.165280782123566 4052 60834 A selective serotonin reuptake inhibitor.
SGTC_652 0437-0092 114 µM -0.97351199456674 0.151571664570274 no 2851 0.165149450895432 3998 3091274
SGTC_185 k048-0037 25.491 µM -0.974334619868707 0.151370518988082 no 2852 0.164945210241435 4103 6827589
SGTC_1736 st036774 51 µM -0.976158200532933 0.150925256352723 no 2853 0.16449303675537 4126 1272247
SGTC_712 r015-0009 80.6 µM -0.976929260855089 0.150737249497161 no 2854 0.164302087207472 4087 6813872 YLR060W FRS1
SGTC_1562 morin hydrate 59.1 µM -0.97730550527859 0.150645566835572 no 2855 0.164208964200849 4139 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2396 5342950 42.78 µM -0.980370484968226 0.149900080961649 no 2856 0.163451636721161 4062 1886677
SGTC_3314 9135860 59.4275 µM -0.980664445292793 0.149828711388913 no 2857 0.163379121315967 4075 25252478
SGTC_2948 9070189 9.45 µM -0.984715939988817 0.148847372489014 no 2858 0.162381810384184 4016 6473636 YDL196W YDL196W
SGTC_2324 6149169 200 µM -0.987706585945235 0.148125750195865 no 2859 0.161648184054783 3978 2888231
SGTC_1103 duloxetine 36.1 µM -0.989332226793591 0.147734478003198 no 2860 0.161250310783334 4168 60835 A selective serotonin reuptake inhibitor.
SGTC_1694 st024011 44.9 µM -0.990482616901639 0.147458011512139 no 2861 0.160969140773947 4093 2787533
SGTC_793 0488-0545 106 µM -0.990960623391749 0.147343237033166 no 2862 0.160852404057497 4095 292548
SGTC_3058 9093861 49.47 µM -0.993073943236717 0.146836523903436 no 2863 0.160336960557625 4090 17217477
SGTC_3071 9117417 49.47 µM -0.994277272661853 0.146548523132998 no 2864 0.160043948613253 4027 45595590 YGL055W OLE1
SGTC_3007 9078383 71.4286 µM -0.994867958984885 0.146407289103256 no 2865 0.15990024409386 4073 6496995
SGTC_2693 st077581 40.7 µM -0.996330790579777 0.146057917250864 no 2866 0.159544724027384 4141 25238761
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.998165585790794 0.145620500801178 no 2867 0.159099535591376 4109 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1924 st058459 75.1 µM -1.00260536559062 0.144565701715886 no 2868 0.158025652971081 4062 688683
SGTC_1049 3226-0134 66 µM -1.00435191633338 0.144152171939549 no 2869 0.157604508939039 4142 5702385
SGTC_3284 9108171 64.8615 µM -1.00535908042704 0.143914069214304 no 2870 0.15736198800967 4080 8687505
SGTC_2700 st077718 96.8 µM -1.00871859958608 0.143121767543215 no 2871 0.156554804535267 4087 904970
SGTC_1296 1068-0102 11.9 µM -1.00888566151665 0.143082445080313 no 2872 0.156514736247892 4103 767053
SGTC_2789 5281112 71.43 µM -1.00961515072085 0.142910825945753 no 2873 0.156339854005812 4119 765948
SGTC_1407 3909-7909 12.3 µM -1.00986863153791 0.142851224802349 no 2874 0.156279116568274 4088 4411780
SGTC_2828 7998861 71.43 µM -1.01062420937762 0.142673664880709 no 2875 0.156098162115153 4066 2988188
SGTC_161 4065-0411 162.148 µM -1.01063334077707 0.142671519925346 no 2876 0.156095976067542 4116 1906281 YLR208W SEC13
SGTC_797 k781-0471 270 µM -1.0115570835728 0.142454646451575 no 2877 0.155874937239885 4072 23738129
SGTC_1433 4060-0023 7.6 µM -1.01359570093019 0.141976815602377 no 2878 0.155387854947421 4115 3840627
SGTC_459 nigericin 15.3 µM -1.01453251766311 0.141757599739124 no 2879 0.155164360597697 4177 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_800 3448-7362 155 µM -1.01980803046361 0.140527407072755 no 2880 0.153909756940458 4183 15991913
SGTC_746 1095-0025 46.6 µM -1.02090681806948 0.140272096333423 no 2881 0.153649294281626 4117 6749286
SGTC_2520 obtusaquinone 4.71 µM -1.02194066128548 0.140032163684925 no 2882 0.153404493031908 4169 5967872
SGTC_3039 9090270 49.47 µM -1.02195687458459 0.140028403151122 no 2883 0.153400655982598 4128 17173750
SGTC_38 0929-0051 58.268 µM -1.02269089093628 0.139858226310832 no 2884 0.153227009814339 4114 1379719
SGTC_2192 5915882 198.485 µM -1.02442031833179 0.139457825965898 no 2885 0.152818394532448 4073 2876149
SGTC_1600 coumarin 106 71.1 µM -1.02504866648028 0.139312542899253 no 2886 0.152670112591628 4185 100336 A hepatotoxic, DNA x-linker.
SGTC_869 0564-0080 44.1 µM -1.02591967163915 0.139111324430042 no 2887 0.152464724672861 4120 6843321
SGTC_1397 3532-0190 20.1 µM -1.02708009151233 0.138843553224476 no 2888 0.152191376143676 4059 5322280
SGTC_2361 9034121 116 µM -1.02790966969891 0.138652340261836 no 2889 0.151996160274784 4114 6496917
SGTC_1739 st037196 92.5 µM -1.02872356088419 0.138464917474067 no 2890 0.151804797567974 4207 612214
SGTC_2015 5119600 184 µM -1.02972976399192 0.13823344787423 no 2891 0.151568439726376 4159 2828786
SGTC_124 0136-0217 7.121 µM -1.03306330519521 0.137468476790717 no 2892 0.150787137121603 4171 3976905
SGTC_3139 9095020 49.47 µM -1.03392794713263 0.137270534286799 no 2893 0.150584924375781 3815 25236292
SGTC_2757 clomiphene 4.22 µM -1.0339781224051 0.137259053639181 no 2894 0.150573195493713 4192 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3096 9117468 49.47 µM -1.03409244016451 0.137232898942751 no 2895 0.150546475050937 4011 41316311
SGTC_454 lyso-paf C-16 6.67 µM -1.03413303474468 0.137223612150464 no 2896 0.150536987301303 4137 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2233 sulbentine 40.3845 µM -1.03491662647682 0.137044434557746 no 2897 0.150353924587792 4112 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2638 epoxomicin 18 µM -1.03543000960065 0.136927130097535 no 2898 0.150234068474804 4112 9915668 A protesome inhibitor.
SGTC_1991 st073000 8.92 µM -1.03590891600212 0.13681776520752 no 2899 0.1501223188335 4191 4301969 YIL048W NEO1
SGTC_2252 omeprazole 400 µM -1.0381267347804 0.136312074299817 no 2900 0.149605528133619 4090 4594 A proton pump inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM -1.03846193254738 0.136235756332 no 2901 0.149527524562257 3964 5282280 An endocannabinoid.
SGTC_1473 k844-0725 134 µM -1.03864524123147 0.13619403290353 no 2902 0.149484878445508 4182 54682906
SGTC_3320 9137005 35.139 µM -1.03935325933659 0.136032960943035 no 2903 0.149320236775902 4152 4908713
SGTC_2154 5570129 200 µM -1.04107306538923 0.135642253559241 no 2904 0.148920819542335 4170 673366
SGTC_2644 guaiazulene 100 µM -1.04299845424779 0.135205754541483 no 2905 0.148474504333593 4139 3515 A coloring agent.
SGTC_2914 7968218 45.32 µM -1.04353735968105 0.135083753627405 no 2906 0.148349743619927 4091 2977111
SGTC_3349 9149703 23.001 µM -1.04703858716155 0.134292961637355 no 2907 0.147540890829917 4152 4910494
SGTC_2199 6590217 200 µM -1.04796167951222 0.134085001414673 no 2908 0.147328131314989 4034 703109
SGTC_2778 tioconazole 65.09 nM -1.04911868927601 0.133824655357979 no 2909 0.147061747713915 4035 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1179 1021-1431 9.29 µM -1.05089152240924 0.133426413461412 no 2910 0.146654207217592 4164 2840958
SGTC_576 1073-0113 22.7 µM -1.05159952560936 0.133267598567001 no 2911 0.146491662766955 4278 5439563
SGTC_1145 3546-0597 10.2 µM -1.0540042716953 0.132729152185973 no 2912 0.14594048070618 4118 875334
SGTC_2588 indole-3-carbinol 100 µM -1.05482203657568 0.132546388434911 no 2913 0.145753362079484 4203 3712 Induces cell cycle arrest.
SGTC_2025 5147754 141 µM -1.05686122824777 0.132091401305479 no 2914 0.145287462796671 4124 315777 YLR208W SEC13
SGTC_679 0422-0091 41.4 µM -1.05717231549465 0.132022085901518 no 2915 0.145216476088641 4154 627384 YHR062C RPP1
SGTC_140 0062-0056 502.533 µM -1.05785116380182 0.131870914333065 no 2916 0.145061651370597 4074 3758964
SGTC_1882 5615643 20 µM -1.05824414338622 0.131783456972132 no 2917 0.144972075434697 4106 2253075
SGTC_1570 verbenone 133 µM -1.05853768429921 0.131718155740917 no 2918 0.14490518989268 4172 29025 A natural terpanoid with antifungal properties.
SGTC_3248 9135562 49.47 µM -1.0667401699657 0.129902452142511 no 2919 0.143044591183374 4136 17650701
SGTC_1609 st001574 46.4 µM -1.0689012987299 0.129426962260487 no 2920 0.142557073348592 4142 3960012
SGTC_1194 1488-0194 225 µM -1.06890685695509 0.129425740900964 no 2921 0.142555820947791 4104 1391452
SGTC_934 2950-0684 338 µM -1.06964743148526 0.129263079121489 no 2922 0.142389018370436 4210 1121253
SGTC_1309 pyrazolanthrone 13.4 µM -1.07228571810426 0.128684750586059 no 2923 0.141795859789488 4145 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2751 anetholtrithion 17.25 µM -1.0746238845168 0.128173712944887 no 2924 0.141271577000145 4171 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3127 9126946 49.47 µM -1.07528415094382 0.128029658411172 no 2925 0.14112376490638 4163 27243249
SGTC_2557 derrustone 83.84 µM -1.07552931839976 0.127976197310972 no 2926 0.141068906627317 4159 629853 An antioxidant.
SGTC_3327 9140648 26.9345 µM -1.07641241431599 0.127783758386615 no 2927 0.140871426365456 4188 8029710
SGTC_1789 tunicamycin 25 nM -1.07825458940098 0.127382970315746 no 2928 0.14046007818253 4074 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_136 0097-0015 404.482 µM -1.07837131401339 0.127357604912968 no 2929 0.140434041680535 4163 4861337
SGTC_918 glabranin 770.725 nM -1.07979189153334 0.127049181028357 no 2930 0.140117431374229 4183 124049 Also referred to as licorice root.
SGTC_2995 9067767 71.4286 µM -1.08093379977485 0.126801636620904 no 2931 0.139863281137641 4186 11673567
SGTC_1246 0422-0085 105 µM -1.08252742950679 0.12645672907947 no 2932 0.139509117001455 4208 264295
SGTC_3242 9133940 49.47 µM -1.08491499186608 0.125941215630365 no 2933 0.138979653692928 4184 17248444
SGTC_2144 5628481 200 µM -1.08569828423389 0.125772409799495 no 2934 0.138806250020556 4162 2818399
SGTC_2369 9071472 200 µM -1.08635040695476 0.125631992532464 no 2935 0.13866199686269 4234 17296037
SGTC_3059 1327-0034 3 µM -1.08638118372607 0.125625368278085 no 2936 0.138655191394916 4056 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2994 9053520 71.4286 µM -1.08969653138948 0.124913214383187 no 2937 0.13792342228092 4231 4647384
SGTC_3255 9139072 49.47 µM -1.09064998424481 0.12470893097396 no 2938 0.13771346321492 4205 17646060
SGTC_730 1436-0052 41.2 µM -1.09492970108795 0.123794850774227 no 2939 0.136773717875432 4222 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_325 2810-4341 181 µM -1.09551803052721 0.123669560509224 no 2940 0.136644875356723 4179 774970
SGTC_3107 9121808 49.47 µM -1.09582866506564 0.12360344380262 no 2941 0.136576880740512 4084 662681
SGTC_1802 st050112 57.9 µM -1.0979108381829 0.123160904722467 no 2942 0.136121712425934 4184 4662563
SGTC_484 loperamide 105 µM -1.09974948621656 0.122771048006613 no 2943 0.135720643439082 4200 3955 An opioid-receptor agonist.
SGTC_3076 9116187 49.47 µM -1.10045752849523 0.122621149722106 no 2944 0.135566412448837 4174 27241210
SGTC_2910 7948405 25.97 µM -1.10072831170251 0.122563856679087 no 2945 0.135507460209865 4107 2971328
SGTC_19 0279-0214 38.434 µM -1.10272347100529 0.122142294464109 no 2946 0.135073635434328 4261 3566274 YBR002C RER2
SGTC_807 1315-0151 48 µM -1.10288559328806 0.122108084019627 no 2947 0.135038425670298 4232 4011080
SGTC_3355 9151058 44.0485 µM -1.10316148165116 0.122049882545681 no 2948 0.134978522627143 4197 17015728
SGTC_1952 st077036 64.1 µM -1.10365444664753 0.121945935044396 no 2949 0.134871531589397 4219 2937007
SGTC_2128 5255449 168.493 µM -1.10399266124425 0.12187465447134 no 2950 0.134798160583373 4154 736008
SGTC_665 3914-0008 307 µM -1.10460721339993 0.121745209169372 no 2951 0.134664912044877 4136 1069549
SGTC_654 1124-0271 80.9 µM -1.11018104983034 0.120575582654311 no 2952 0.133460508498758 4178 5403748
SGTC_1258 0671-0043 57.1 µM -1.11111373332915 0.120380641573414 no 2953 0.133259698621774 4226 4298767
SGTC_2311 7694451 200 µM -1.1117301984704 0.120251915516943 no 2954 0.133127085788438 4180 2163142
SGTC_1596 piperlongumine 63 µM -1.11177894128172 0.1202417415134 no 2955 0.133116604201617 4247 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_893 0958-0369 48.9 µM -1.11218986786188 0.120155993619449 no 2956 0.133028261695753 4120 6819948
SGTC_2959 9079155 11 µM -1.1152873803575 0.11951102328043 no 2957 0.132363645749706 4243 16189457
SGTC_1931 st074438 57.1 µM -1.11757478005504 0.119036306648693 no 2958 0.131874322511361 4200 2787313
SGTC_2890 9046729 58.44 µM -1.11799861650736 0.118948491946671 no 2959 0.131783792123447 4167 903329
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.12106481240651 0.118314569111602 no 2960 0.131130137647475 4299 688664
SGTC_2773 thioridazine 9.09 µM -1.1237508725627 0.117761203534059 no 2961 0.130559364046427 4212 5452 An antipsychotic.
SGTC_1948 st076329 66.6 µM -1.13208976604328 0.116054953451285 no 2962 0.128798348489713 4118 24208413
SGTC_2776 terbinafine 19.92 µM -1.13245417497643 0.115980792753458 no 2963 0.128721769845592 4240 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_77 0828-0286 12.516 µM -1.1329502060303 0.115879899772284 no 2964 0.128617582270955 4122 745345
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.13521968145524 0.115419082133607 no 2965 0.128141642558441 4319 688801
SGTC_3011 9081274 71.4286 µM -1.13682617987997 0.115093670337202 no 2966 0.127805478386859 4218 6625322
SGTC_2268 7933382 153.85 µM -1.14657793057803 0.113132354662967 no 2967 0.125778050973115 4267 935025 YOR257W CDC31
SGTC_945 3381-0768 11.3 µM -1.14779322140808 0.112889611303442 no 2968 0.125526968162675 4270 1126236 YIL048W NEO1
SGTC_1403 3909-7815 62.9 µM -1.1497030233737 0.112508897248356 no 2969 0.125133104339236 4198 6615483
SGTC_1400 3771-8998 51.5 µM -1.15090624340206 0.112269509903671 no 2970 0.124885404494305 4165 670767
SGTC_1611 st001856 99.4 µM -1.15095976744026 0.112258869460015 no 2971 0.124874393778745 4216 647478
SGTC_3236 9132701 49.47 µM -1.15163781272713 0.112124138158518 no 2972 0.124734968182112 4235 24282524
SGTC_1771 st048882 4.1505 µM -1.15280374987786 0.111892730423711 no 2973 0.124495472452856 4279 4580403
SGTC_1019 4262-0212 3.4 µM -1.15290733151773 0.111872188734274 no 2974 0.124474211257204 4260 4677213
SGTC_1971 st069429 63.5 µM -1.15342953910732 0.111768668728765 no 2975 0.124367061448085 4231 1246522 YGL099W LSG1
SGTC_2418 pentamidine 31.67 µM -1.15418446725487 0.111619136431602 no 2976 0.124212274638166 4192 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.15549362702346 0.111360164204126 no 2977 0.123944170443611 4321 4213774
SGTC_3009 9080819 71.4286 µM -1.15607820889359 0.111244663795708 no 2978 0.123824584205698 4264 17027216
SGTC_1463 k081-0032 34.1 µM -1.15984194869948 0.110503085677998 no 2979 0.123056580723507 3851 977755
SGTC_919 tnp00227 403.569 nM -1.16510229376836 0.109472575846109 no 2980 0.121988794257231 4218 1269246 A methoxyflavone. YNL221C POP1
SGTC_1183 1254-0324 198 µM -1.17224039606304 0.108085273662432 no 2981 0.120550277082708 4333 5799357
SGTC_993 3909-8757 62.7 µM -1.17502118568326 0.107548262846067 no 2982 0.119993120023202 4210 4288324 YLR208W SEC13
SGTC_617 3770-0098 35 µM -1.1798013745194 0.106629637231612 no 2983 0.119039611366848 4182 5962639
SGTC_1691 st019933 84.6 µM -1.1818775768198 0.106232415243194 no 2984 0.118627140205798 4262 6176082
SGTC_499 genistein 192 µM -1.18241108926922 0.106130515712413 no 2985 0.118521312615289 4374 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_871 0574-0004 149 µM -1.18422021277024 0.105785503424057 no 2986 0.118162951453462 4241 9551173
SGTC_2606 farnesol 9.78 µM -1.18477150186617 0.10568053015178 no 2987 0.118053901550753 4305 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2312 7706453 155.7 µM -1.18722985151894 0.10521334217024 no 2988 0.117568484559387 4267 976098
SGTC_3049 9092223 49.47 µM -1.18776485664811 0.10511186740606 no 2989 0.117463031826523 4252 8623917
SGTC_3287 9117173 37.0625 µM -1.18983484001543 0.104719919537119 no 2990 0.117055656535317 4275 2789709
SGTC_772 k072-0172 35.3 µM -1.19096644532476 0.104506099981758 no 2991 0.116833378907722 4322 5861980
SGTC_734 2023-0417 80 µM -1.19154126169593 0.104397608261654 no 2992 0.116720584220809 4276 3935732
SGTC_364 0083-0097 67.7 µM -1.19367317386752 0.103995940605978 no 2993 0.116302919023611 4331 5207356
SGTC_2902 5787006 60.46 µM -1.19391973535753 0.103949559035653 no 2994 0.116254683396722 4223 591003
SGTC_3251 9135047 49.47 µM -1.19539913192228 0.103671579433956 no 2995 0.11596556234004 4306 17682963
SGTC_2415 st077333 57.7 µM -1.19633028701645 0.103496891573096 no 2996 0.115783847047988 4321 2766255
SGTC_2346 9031566 143.75 µM -1.19655828366746 0.103454151203597 no 2997 0.11573938424534 4248 4771086
SGTC_3043 9092303 49.47 µM -1.19914810127265 0.102969561665922 no 2998 0.115235181639768 4290 25236084
SGTC_1665 st014639 11.4 µM -1.19931882563431 0.102937674883328 no 2999 0.11520199885026 4346 981133 YIL048W NEO1
SGTC_910 3454-3003 490 µM -1.20013622289815 0.102785106147244 no 3000 0.115043219796551 4193 820824
SGTC_3277 9138724 49.47 µM -1.20039904813943 0.102736084252089 no 3001 0.114992199190104 4244 15943418
SGTC_2137 5261020 140 µM -1.2005040039757 0.102716512745106 no 3002 0.114971829272432 4259 763655
SGTC_1383 3049-0032 20.7 µM -1.20378143877441 0.102106720030187 no 3003 0.114337032803224 4349 712864
SGTC_2466 5983409 37.09 µM -1.2065045017061 0.101602079266975 no 3004 0.113811512187218 4295 2879657
SGTC_2809 7964133 12.99 µM -1.20662755279664 0.101579318280862 no 3005 0.113787805425372 4293 1253665
SGTC_522 1273-0010 11.6 µM -1.20727901420035 0.101458878134254 no 3006 0.113662354893413 4347 5705015
SGTC_1666 st014829 29 µM -1.21101132810574 0.100770864193472 no 3007 0.112945531581895 4284 3858230
SGTC_1500 4488-1866 171 µM -1.21163268975576 0.100656653672317 no 3008 0.112826507689517 4361 2900003
SGTC_3282 9108498 15.4605 µM -1.21181040789938 0.100624005232438 no 3009 0.112792481662102 4266 16459645
SGTC_1356 1502-0781 85.8 µM -1.21187590937304 0.100611973964171 no 3010 0.112779942556773 4289 567702
SGTC_2441 5730946 39.09 µM -1.21263377135841 0.100472846666623 no 3011 0.112634935577996 4346 1774275
SGTC_2819 7996655 46.38 µM -1.21306592466073 0.100393575407236 no 3012 0.112552308331628 4251 6456960
SGTC_2736 butenafine 14.65 µM -1.21459579762438 0.10011331271223 no 3013 0.112260146223256 4240 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_838 0109-0203 71.4 µM -1.21466769015104 0.100100156539112 no 3014 0.112246430146251 4324 759422
SGTC_1574 spiramycin 23.7 µM -1.21653021643744 0.0997597581897283 no 3015 0.11189150383575 4259 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_748 act1.228 77.9 µM -1.21671353229379 0.0997263008507077 no 3016 0.111856614272721 4256 4421505 YNR035C ARC35
SGTC_635 k038-0028 24.7 µM -1.21966891513365 0.0991880390838413 no 3017 0.111295204993644 4304 4035102
SGTC_1306 1185-0270 9.02 µM -1.22301188159446 0.0985817512307798 no 3018 0.110662604326734 4331 1548076
SGTC_1959 st077091 55.8 µM -1.22516720479139 0.0981922980900678 no 3019 0.110256114084215 4308 821356 YKL052C ASK1
SGTC_16 erodoxin 22.806 µM -1.22541761842751 0.0981471231274682 no 3020 0.11020895602997 4317 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_232 clozapine 119 µM -1.2255317385819 0.0981265407467923 no 3021 0.110187469649832 4292 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1153 4055-0057 267 µM -1.22771803884253 0.0977328363724274 no 3022 0.109776416191906 4356 882706
SGTC_1703 st026983 48.3 µM -1.22935646337823 0.0974385523278876 no 3023 0.109469092966501 4338 1104023
SGTC_211 3455-0679 143.504 µM -1.22951476526722 0.0974101535573105 no 3024 0.109439432667955 4334 748649
SGTC_1845 st056753 3.01 µM -1.22982420475825 0.0973546587972626 no 3025 0.109381471079966 4289 5375839
SGTC_2426 5582046 32.21 µM -1.22994939739963 0.0973322133880781 no 3026 0.109358027319589 4322 2251934
SGTC_460 trequinsin 123 µM -1.23294600001939 0.0967960940651248 no 3027 0.108797955845128 4389 5537 A vasodilator.
SGTC_475 α-linolenic acid 10 µM -1.23389199398586 0.0966272983570003 no 3028 0.108621576602186 4323 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1357 1503-1303 39.5 µM -1.2340602234355 0.0965973034775596 no 3029 0.108590232009559 4298 292895
SGTC_1444 4112-3581 28 µM -1.23471799590464 0.0964800899865719 no 3030 0.10846773797649 4375 2877249
SGTC_3231 9132313 49.47 µM -1.23645332000049 0.0961713609301205 no 3031 0.108145053482354 4257 4905967
SGTC_2235 salicylic acid 500 µM -1.23674914780357 0.0961188031607422 no 3032 0.108090113151565 4344 338 A COX inhibitor and kinase inhibitor.
SGTC_1846 st056244 14.8 µM -1.23691608412372 0.0960891540107551 no 3033 0.108059119064989 4338 5393182
SGTC_987 1497-1013 404 µM -1.23745159585572 0.0959940884706142 no 3034 0.107959736932455 4326 1676435
SGTC_2747 doxorubicin 7.63 µM -1.23750953545217 0.0959838070192296 no 3035 0.107948988247483 4326 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2183 6420625 130.508 µM -1.23827668155967 0.0958477523506233 no 3036 0.107806743509468 4330 2897619
SGTC_899 1083-0020 478 µM -1.2384146335465 0.0958233013862021 no 3037 0.107781178689496 4378 767123
SGTC_3152 9099253 49.47 µM -1.23964600487019 0.0956052532010485 no 3038 0.10755317834058 4205 25236131
SGTC_234 nsc-17383 10.7 µM -1.2396687782032 0.0956012239971795 no 3039 0.107548964912913 4336 408974
SGTC_2255 7941087 197.44 µM -1.24579617014521 0.0945216611708567 no 3040 0.106419617993111 4436 935561
SGTC_3095 9117207 49.47 µM -1.24591140781169 0.0945014443278691 no 3041 0.10639846075031 4301 17015229
SGTC_2973 9094665 17.96 µM -1.24600485799918 0.0944850521355507 no 3042 0.106381305844723 4322 25237061 YIL048W NEO1
SGTC_2362 9071156 126 µM -1.24849002476628 0.0940498953734294 no 3043 0.10592582959896 4334 653133
SGTC_1868 st057644 42.7 µM -1.24854480133876 0.0940403205903118 no 3044 0.105915806160519 4358 688665
SGTC_1359 1582-0056 520 nM -1.25226744011011 0.0933912985775886 no 3045 0.105236214511429 4392 3661189
SGTC_3108 9121785 49.47 µM -1.25331898558742 0.0932085680211418 no 3046 0.105044820857941 4155 17140271
SGTC_297 0986-0032 24 µM -1.25809593016183 0.0923817878942293 no 3047 0.104178532512051 4301 2847425
SGTC_199 4063-0024 41.6 µM -1.26232197541405 0.091654891091125 no 3048 0.103416476158098 4363 306215
SGTC_936 3005-4620 401 µM -1.26804873073262 0.0906766402117334 no 3049 0.102390274364705 4380 777207
SGTC_2886 9058944 51.95 µM -1.26815106851448 0.0906592295091361 no 3050 0.102372003609265 4239 4949929
SGTC_2663 amphotericin b 100 µM -1.26867082114851 0.090570842416946 no 3051 0.102279246782216 4357 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1017 4239-0030 168 µM -1.27002329812143 0.0903411453172372 no 3052 0.102038165651338 4359 1149593
SGTC_2024 5144227 134 µM -1.27108157465847 0.0901617154721906 no 3053 0.101849814752917 4334 3475211
SGTC_822 1487-0950 154 µM -1.27518671689388 0.0894681972059372 no 3054 0.101121580846381 4351 1958375
SGTC_1268 0828-0275 2.46 µM -1.27743688706192 0.0890897433016667 no 3055 0.100724024445063 4407 745337
SGTC_2090 5301565 104.445 µM -1.27983710019003 0.0886873684685813 no 3056 0.100301216453966 4347 2056344
SGTC_2933 9026794 32.47 µM -1.28511478026536 0.0878073739953588 no 3057 0.0993760886939483 4294 17586027
SGTC_138 0850-0259 40.9225 µM -1.30626843246207 0.0843455472202361 no 3058 0.0957306441257604 4296 6813004
SGTC_198 3454-2873 16.191 µM -1.3079049640341 0.0840820562084183 no 3059 0.0954527728099793 4379 710957
SGTC_801 0866-0028 10.1 µM -1.30819786295638 0.0840349630629854 no 3060 0.0954031033730156 4390 6849771
SGTC_1502 4534-4282 27.7 µM -1.31211651675305 0.0834068139740462 no 3061 0.0947404119551467 4343 3278949
SGTC_1935 st074532 41.6 µM -1.31291173200992 0.0832797750881376 no 3062 0.0946063465654344 4337 2829742
SGTC_2532 xanthone 78.9 µM -1.31334367796063 0.0832108309544197 no 3063 0.0945335834075595 4401 7020 An insecticide.
SGTC_2424 5537928 59.2 µM -1.3163373708066 0.082734178008152 no 3064 0.094030416516455 4379 5382802
SGTC_2918 7977171 22.06 µM -1.32214046428482 0.081816071068419 no 3065 0.0930606908071853 4374 2236483
SGTC_1196 1588-0294 184 µM -1.32452850379535 0.0814404976432608 no 3066 0.0926637915108879 4409 6144269
SGTC_1825 st052143 62.6 µM -1.32504889093076 0.0813588277723527 no 3067 0.0925774680033072 4426 674173
SGTC_1668 st014914 51.6 µM -1.32554759768313 0.0812806184193275 no 3068 0.0924947967442673 4394 2839556
SGTC_718 1130-0073 349 µM -1.32879389298419 0.0807729060055473 no 3069 0.0919579887783135 4400 6740020
SGTC_1016 4226-1401 38 µM -1.34008581497737 0.0790255220005473 no 3070 0.0901087236081037 4389 2901613
SGTC_3181 9108277 49.47 µM -1.34158980689939 0.0787949619201621 no 3071 0.0898645165027092 4355 17097298
SGTC_302 1094-0063 18.9 µM -1.34452386310491 0.0783466422845985 no 3072 0.0893895225659531 4369 5440289
SGTC_1687 st020778 55.3625 µM -1.3446006119987 0.0783349411754565 no 3073 0.0893771228119381 4410 4259299
SGTC_704 1310-0270 142 µM -1.34671535924873 0.0780130486213302 no 3074 0.0890359618170808 4393 5718033
SGTC_2639 lactacystin 53 µM -1.34781375166392 0.0778462552232113 no 3075 0.088859146891795 4423 3870 A proteasome inhibitor.
SGTC_3164 9100705 49.47 µM -1.35080041560365 0.0773940920042697 no 3076 0.0883796874659579 4407 17174235
SGTC_925 2064-1272 59.6 µM -1.35518369220745 0.0767341057775385 no 3077 0.0876795195476966 4374 6815817
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.36098756971621 0.0758668169018389 no 3078 0.0867588088488342 4403 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1424 4048-1941 275 µM -1.36605856994541 0.0751151722042331 no 3079 0.0859602903236242 4481 X1424
SGTC_2748 diazoxide 86.69 µM -1.3679809867858 0.0748317127541296 no 3080 0.0856590138055243 4497 3019 A potassium channel activatior.
SGTC_3190 9110366 49.47 µM -1.37004365081779 0.0745284822678461 no 3081 0.0853366380193272 4426 17123768
SGTC_2967 9089538 49.85 µM -1.37447709236863 0.0738799014124958 no 3082 0.084646808591134 4412 728216
SGTC_3027 9089541 49.47 µM -1.37616775024704 0.0736337094381221 no 3083 0.0843848520278488 4413 9943819
SGTC_179 1273-0063 6.77 µM -1.37650458235669 0.0735847352837182 no 3084 0.0843327348051091 4394 3108139
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.37915551214115 0.0732001687181898 no 3085 0.0839234056429533 4467 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3040 9091894 49.47 µM -1.37932914458498 0.0731750338684751 no 3086 0.0838966472697598 4279 25236966
SGTC_1484 3473-2379 286 µM -1.37958296875211 0.0731383024326825 no 3087 0.0838575421368457 4544 671917
SGTC_2981 9013952 38.96 µM -1.38309750904341 0.07263115485983 no 3088 0.0833174846898523 4376 2996344
SGTC_2071 5230951 39.92 µM -1.38963782081328 0.0716945642083598 no 3089 0.0823194424763807 4470 1799272
SGTC_2085 5307070 144.047 µM -1.3960293108007 0.0707882636402524 no 3090 0.0813528344232174 4375 2840351
SGTC_2027 5150920 200 µM -1.39691988664108 0.0706626835854839 no 3091 0.0812188318355214 4366 786715
SGTC_1946 st076057 65.1 µM -1.39693765610265 0.0706601796578573 no 3092 0.0812161598073137 4413 953009
SGTC_2088 5278280 127.392 µM -1.40299824823971 0.0698101414870241 no 3093 0.0803086806588207 4476 791502
SGTC_2829 7992743 58.44 µM -1.40339426397451 0.0697548727921737 no 3094 0.0802496512631609 4415 16462845
SGTC_463 ikarugamyin 104 µM -1.40874390595775 0.0690115633756052 no 3095 0.0794554535695687 4587 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_614 0462-0418 107 µM -1.41356244319289 0.0683472879723551 no 3096 0.0787452075136722 4217 5188303
SGTC_1136 pergolide 1.05886 µM -1.41629617952409 0.0679726194408761 no 3097 0.0783444029754148 4386 47811 A dopamine receptor agonist.
SGTC_2488 5268135 45.7 µM -1.4205022879179 0.067399256626781 no 3098 0.0777307514942547 4474 1270356 YLR208W SEC13
SGTC_3317 9138495 8.753 µM -1.42077956286088 0.0673615911584693 no 3099 0.0776904269332123 4356 17020139
SGTC_892 0929-0076 29 µM -1.42214890704691 0.0671758158142063 no 3100 0.0774915137491016 4431 5751038
SGTC_2382 9035899 200 µM -1.42309071023812 0.0670482739432958 no 3101 0.0773549305056497 4449 6462679
SGTC_1161 k007-0610 110 µM -1.42387037129511 0.0669428316168923 no 3102 0.0772420000321334 4388 5843850
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.42575721478621 0.066688183423594 no 3103 0.0769692174573461 4458 2346 DNA damaging agent; causes G2/M arrest.
SGTC_144 4161-2749 112.381 µM -1.4268129854385 0.0665460241720044 no 3104 0.0768169036100765 4439 797501 YMR168C CEP3
SGTC_954 1189-0853 2.85 µM -1.43047036553436 0.0660553722084553 no 3105 0.0762910326404199 4375 2828194
SGTC_1705 st027868 56.3335 µM -1.43171929323147 0.0658884671137327 no 3106 0.0761120863066785 4382 292948
SGTC_1462 k081-0014 26.5 µM -1.43252835815989 0.0657805192751917 no 3107 0.0759963341481637 3889 3270634
SGTC_1984 st072354 53.1 µM -1.43330851674201 0.0656765580817069 no 3108 0.0758848445742822 4328 5762938
SGTC_2204 7233102 200 µM -1.44099224241568 0.0646594455786458 no 3109 0.0747934372090421 4425 2172480
SGTC_2331 7980721 200 µM -1.44337982811012 0.0643458992746584 no 3110 0.0744567516593406 4419 2981221
SGTC_988 1497-1057 103 µM -1.44763342532039 0.0637902306860079 no 3111 0.0738597989535126 4449 3533044
SGTC_486 niguldipine 82 µM -1.44767521355964 0.0637847902542896 no 3112 0.073853952560483 4538 1236 A calcium channel blocker.
SGTC_671 0560-0003 407 µM -1.45057514007692 0.0634081282164462 no 3113 0.0734491009362916 4408 3238678
SGTC_3128 9127691 49.47 µM -1.45146073688599 0.0632934466794306 no 3114 0.0733258038532741 4482 41316314
SGTC_542 3381-0244 89.3 µM -1.45332654418127 0.0630523600315351 no 3115 0.0730665553461354 4490 1112843
SGTC_2061 5245884 80.95 µM -1.45356372068675 0.0630217650395315 no 3116 0.073033650672426 4438 573863
SGTC_2888 9058547 12.99 µM -1.4569125201481 0.0625910141199526 no 3117 0.0725702647714548 4399 16476514
SGTC_3354 9151612 71.43 µM -1.46531463954163 0.0615203646695023 no 3118 0.0714175471067937 4468 27261949
SGTC_2999 9069765 71.4286 µM -1.46774669478879 0.0612131415941262 no 3119 0.071086520878726 4424 2097066
SGTC_1615 st002656 86.5 µM -1.46805347668263 0.0611744734675276 no 3120 0.0710448487223884 4480 1584458
SGTC_2861 9024595 19.48 µM -1.46859890921676 0.0611057719159205 no 3121 0.0709708054490477 4401 16482810
SGTC_2852 9023854 51.95 µM -1.46896747111561 0.0610593827738918 no 3122 0.0709208061935042 4481 19798528
SGTC_1132 3456-3614 2.5 µM -1.47166916047052 0.0607201738968538 no 3123 0.0705551197009524 4459 3125502
SGTC_3205 9113483 49.47 µM -1.47684581431174 0.060074341698798 no 3124 0.069858486263737 4481 17018033
SGTC_3218 9131285 49.47 µM -1.48121972806363 0.0595328612316593 no 3125 0.0692740154026373 4462 17156417
SGTC_412 gemfibrozil 100 µM -1.48338189185193 0.0592666069378499 no 3126 0.0689864878739811 4437 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1064 honokiol 6.76 µM -1.48497363725921 0.0590711928166173 no 3127 0.0687754038633384 4514 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1866 st057638 64 µM -1.48817183716685 0.0586800870128428 no 3128 0.0683527911735731 4504 688802
SGTC_529 4076-0302 30.3 µM -1.4969920260751 0.0576120004882732 no 3129 0.0671976664506826 4455 5816522
SGTC_817 1391-0715 46 µM -1.49808436888325 0.0574807934222101 no 3130 0.0670556658573431 4484 1353946
SGTC_2151 5563267 85.4165 µM -1.49896316882889 0.0573754068377404 no 3131 0.0669415936047146 4548 5310824
SGTC_2891 9063876 19.48 µM -1.49958483740906 0.0573009475616006 no 3132 0.0668609888741147 4523 6472478
SGTC_952 1185-0122 232 µM -1.50128899549134 0.0570972248698054 no 3133 0.0666404150102147 4443 678600
SGTC_1768 st044301 37.178 µM -1.50158975689376 0.0570613297690927 no 3134 0.0666015451698199 4501 3931349
SGTC_2384 9036245 200 µM -1.5081259702542 0.0562856292135792 no 3135 0.0657611448050662 4446 6462766
SGTC_448 monastrol 171 µM -1.51148191427576 0.055890597259039 no 3136 0.0653328565412239 4413 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2241 6772625 37.8075 µM -1.51250818310993 0.0557702316900702 no 3137 0.0652023162371421 4305 2285411
SGTC_2908 7930301 100 µM -1.51302748906036 0.055709403065627 no 3138 0.0651363382322238 4464 2223178
SGTC_2335 9018011 154.17 µM -1.51851887242544 0.055069372345201 no 3139 0.0644418227800847 4474 6458208
SGTC_1257 0669-0121 16 µM -1.52308494557316 0.0545416239491404 no 3140 0.0638687273593924 4496 4307855
SGTC_644 1498-1197 63.3 µM -1.52686844454873 0.0541073628538314 no 3141 0.0633968638293289 4555 6741615
SGTC_1805 st050013 60.3 µM -1.52829118405435 0.0539447739160052 no 3142 0.0632201288963969 4464 4037144
SGTC_798 1287-0182 476 µM -1.5285152293177 0.0539192055838214 no 3143 0.0631923326389209 4546 1649755
SGTC_2642 cholecalciferol 100 µM -1.53061397060034 0.0536801601941619 no 3144 0.0629324134334044 4515 9821465 A vitamin D precursor, similar to steriods.
SGTC_1445 4239-0156 97.7 µM -1.53137415882835 0.0535937825807912 no 3145 0.0628384734450046 4545 4008346
SGTC_56 0957-0365 83.25 µM -1.53346280137173 0.0533570239979701 no 3146 0.0625809326471137 4450 6752360
SGTC_2567 aureobasidin a 60 nM -1.53661032424286 0.0530018024558202 no 3147 0.062194381406803 4580 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_672 1441-0018 53.7 µM -1.53661815178144 0.0530009214030336 no 3148 0.0621934224239538 4511 251141
SGTC_2290 7904846 200 µM -1.53807937174 0.0528366526372971 no 3149 0.0620146045302642 4549 2962154
SGTC_328 k915-0120 63.5 µM -1.53992172208293 0.0526301135401596 no 3150 0.0617897176065955 4524 6624543
SGTC_1737 st035557 69.7 µM -1.54188609504874 0.0524106012488087 no 3151 0.0615506377481047 4364 5716916
SGTC_863 0466-0191 129 µM -1.54436597836179 0.0521345210744349 no 3152 0.0612498485668025 4563 765160 YPR165W RHO1
SGTC_1664 st014217 9.02 µM -1.54506800213126 0.0520565763988431 no 3153 0.0611649078581038 4588 3982782
SGTC_3001 9076041 71.4286 µM -1.54978949958329 0.051534757816126 no 3154 0.0605960240681551 4526 16004211
SGTC_142 0335-0849 62.6745 µM -1.5542233223172 0.0510485280974908 no 3155 0.0600655781109439 4489 3889043 YPR107C YTH1
SGTC_2008 4012253 172 µM -1.55867048729084 0.0505645099656282 no 3156 0.0595371951937314 4515 603940
SGTC_424 splitomicin 100 mM -1.56073200089606 0.0503413836318822 no 3157 0.0592934987209616 4514 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2375 9072683 200 µM -1.56079708932067 0.0503343516349886 no 3158 0.0592858172181353 4572 16798029
SGTC_2440 5628896 157.78 µM -1.56144846783991 0.0502640213748135 no 3159 0.0592089868298033 4505 5522048
SGTC_1096 rimcazole 32.2 µM -1.56248062131819 0.0501527387130774 no 3160 0.0590874037801293 4477 18528119 A dopamine reuptake inhibitor.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.56401173480087 0.0499880220578066 no 3161 0.058907406306146 4478 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1461 k072-0203 53.8 µM -1.56563119512379 0.0498142708325755 no 3162 0.0587174912773582 4415 5418714
SGTC_380 3970-0968 6 µM -1.57066975693735 0.0492767651081646 no 3163 0.0581296887707468 4432 2891601
SGTC_2685 mycophenolic acid 18.85 µM -1.57413553503978 0.0489097371492671 no 3164 0.0577280594360886 4537 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3111 9122088 49.47 µM -1.58355565851503 0.047923170196692 no 3165 0.056647435629396 4474 16876704
SGTC_2475 5812728 15.03 µM -1.58720919050201 0.0475448506216551 no 3166 0.0562326369722821 4488 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1004 4084-0029 199 µM -1.59068974044799 0.04718667199644 no 3167 0.0558397084865146 4535 716894 YLR208W SEC13
SGTC_959 1222-0044 107 µM -1.59380199851898 0.0468682285476024 no 3168 0.0554901948977455 4528 6083612
SGTC_2033 5192550 145 µM -1.59593168530948 0.0466513159151945 no 3169 0.0552520231987391 4550 182073
SGTC_2777 climbazole 1.536 µM -1.59634330116858 0.0466094850951942 no 3170 0.0552060837332307 4350 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1346 1488-2224 62.4 µM -1.59671711307784 0.046571522218851 no 3171 0.0551643896229236 4556 3722427
SGTC_1478 0453-0656 35.7 µM -1.5972532825245 0.0465171142706976 no 3172 0.0551046299619716 4585 5258496
SGTC_1375 2910-0797 186 µM -1.6018949216999 0.0460482322820539 no 3173 0.054589423835943 4547 742508
SGTC_786 4544-0069 423 µM -1.60919302307275 0.0453186890008295 no 3174 0.0537870707626253 4542 748821 YLR208W SEC13
SGTC_2187 6125751 200 µM -1.61094462868795 0.0451449832583207 no 3175 0.0535958958084955 4571 874498
SGTC_2941 9056145 11.23 µM -1.6133827274122 0.0449040906823369 no 3176 0.0533306916858489 4507 2119517
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.61511813314931 0.0447332578359755 no 3177 0.0531425574061202 4533 6708760
SGTC_1361 1608-0041 5.61 µM -1.61680954260735 0.044567259991717 no 3178 0.0529596994682854 4561 X1361
SGTC_3252 9135871 49.47 µM -1.61820658548987 0.0444305262913508 no 3179 0.0528090420532662 4570 17682838
SGTC_1270 0831-1170 17.3 µM -1.62320841121303 0.0439437486261956 no 3180 0.0522724301962593 4565 6764716
SGTC_2641 levomentholum 100 µM -1.62428580879868 0.0438394613720003 no 3181 0.052157412272308 4566 16666
SGTC_86 0417-1630 471.922 µM -1.63922132431268 0.0424142354175672 no 3182 0.0505835871542602 4570 3634867
SGTC_770 0389-1121 67.2 µM -1.64334318254222 0.0420275744829467 no 3183 0.050155974267811 4594 6753108
SGTC_61 0978-8327 98.565 µM -1.64602662889766 0.0417773842605062 no 3184 0.0498791383545682 4501 6150059 YHR072W ERG7
SGTC_42 0133-0086 60.653 µM -1.64821487710515 0.0415742576899813 no 3185 0.0496542925130568 4461 162923 Model of phenazepam hydroxylation.
SGTC_3336 9143619 71.43 µM -1.65105347980085 0.0413119542082564 no 3186 0.0493638276008494 4572 45595730
SGTC_2045 5106652 78.05 µM -1.6530757361835 0.0411259053924911 no 3187 0.0491577253899642 4566 673349
SGTC_864 0469-0573 172 µM -1.65867303002406 0.0406144915201344 no 3188 0.0485908484338533 4549 689425
SGTC_1994 st072947 40.9 µM -1.665511136576 0.0399967250228123 no 3189 0.0479054118345214 4624 5286565 YDL195W SEC31
SGTC_2121 5257820 149.641 µM -1.66676810989393 0.0398840029634268 no 3190 0.0477802618438627 4594 791256
SGTC_1020 4335-0961 93.3 µM -1.66824342099059 0.0397520304821519 no 3191 0.0476337072447948 4539 669075
SGTC_2469 5655019 90.81 µM -1.67176865111852 0.0394381219511476 no 3192 0.0472849753872156 4626 2788239
SGTC_763 3453-1109 128 µM -1.67397425085086 0.0392427491789285 no 3193 0.0470678299983566 4606 1560353
SGTC_1961 st076550 68.7 µM -1.67566294011994 0.0390936975196281 no 3194 0.0469021164071648 4577 1579337
SGTC_2536 dehydroabietamide 32.04 µM -1.67645218080376 0.0390241936262191 no 3195 0.0468248276605534 4593 3983547
SGTC_2476 5806916 10.51 µM -1.67794421348126 0.03889307376647 no 3196 0.0466789950558134 4503 2870194
SGTC_595 3909-8003 73.7 µM -1.69436678838379 0.0374734333052579 no 3197 0.0450978032050841 4632 699517
SGTC_1834 st055981 52.8 µM -1.69439231543543 0.0374712600270615 no 3198 0.0450953793987436 4571 471719 YDL150W RPC53
SGTC_331 k048-0133 24.5 µM -1.69466568666637 0.0374479926705669 no 3199 0.0450694292355939 4592 6813582
SGTC_2269 7935389 174.42 µM -1.69692905125243 0.0372558045981274 no 3200 0.0448550374212825 4596 97605
SGTC_235 0330-0087 5 mM -1.69843601571453 0.0371282918474523 no 3201 0.0447127496921354 4629 46494818 YHR062C RPP1
SGTC_2378 9074213 121.43 µM -1.69873527488001 0.0371030123385926 no 3202 0.0446845369182858 4577 657714
SGTC_2946 9065502 71.43 µM -1.71239436992792 0.0359640694008685 no 3203 0.0434120079573462 4476 16489101
SGTC_2955 9076254 12.21 µM -1.71250661363522 0.0359548301262404 no 3204 0.0434016734286462 4530 16459619
SGTC_1867 st057372 64 µM -1.71491048592348 0.0357574230725347 no 3205 0.0431808199242034 4578 688837
SGTC_3003 9075612 71.4286 µM -1.7154196619144 0.0357157235109281 no 3206 0.0431341565495952 4603 6501993
SGTC_946 3434-1334 87.4 µM -1.71904954737466 0.0354196032529521 no 3207 0.0428026751937788 4558 4047976
SGTC_2780 5215298 71.43 µM -1.72294655240744 0.0351039358550674 no 3208 0.0424490954083865 4602 2834131
SGTC_1379 2144-0755 36.5 µM -1.72460218595675 0.0349705257974469 no 3209 0.0422995946182756 4624 5392327
SGTC_1828 st055811 49 µM -1.72664867380753 0.0348061963032846 no 3210 0.0421153893712066 4600 5877589
SGTC_2340 7987427 183.45 µM -1.7367640061129 0.0340032387620973 no 3211 0.0412144173841619 4589 2239331
SGTC_857 0438-0306 1.35 µM -1.74059985156689 0.0337027596395129 no 3212 0.040876871846007 4638 4686136
SGTC_1667 st014849 34.6 µM -1.74125730471687 0.0336514783592511 no 3213 0.0408192432528787 4699 5348460
SGTC_1171 0368-0077 21.4 µM -1.75010827008794 0.032967334180907 no 3214 0.0400498164958386 4580 3239779
SGTC_3056 9094900 49.47 µM -1.7523890414223 0.0327929093291942 no 3215 0.0398534672466999 4594 25236784
SGTC_1721 st082152 9.2685 µM -1.75698307185416 0.032443884453496 no 3216 0.0394603473194309 4560 5296051
SGTC_2583 asiatic acid 100 µM -1.76178063355207 0.032082673816372 no 3217 0.0390531840278585 4587 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2156 5649887 115 µM -1.76321143630914 0.0319755930280765 no 3218 0.0389324178279551 4644 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2831 7999036 19.48 µM -1.76363056004677 0.0319442819006529 no 3219 0.0388970995412534 4571 2988270
SGTC_2032 5185112 25.99 µM -1.76824616346579 0.0316011398164284 no 3220 0.0385098798968445 4496 5718189
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.770463277382 0.0314373971867334 no 3221 0.0383249983317897 4607 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2325 6158266 200 µM -1.77090740865383 0.0314046808106434 no 3222 0.0382880500787082 4586 3623240
SGTC_613 3914-0030 117 µM -1.77728062168459 0.0309382984517081 no 3223 0.0377610401778442 4373 1145395
SGTC_2555 cholic acid 100 µM -1.78017291364447 0.0307285436373368 no 3224 0.0375238333868533 4585 6708657 Influences liver metabolism.
SGTC_89 0302-0250 142.109 µM -1.78029356719232 0.0307198192464377 no 3225 0.0375139646736469 4670 4203518 YLR208W SEC13
SGTC_600 1495-0418 41.6 µM -1.78431276951554 0.0304303630102272 no 3226 0.0371864282144311 4612 5377768
SGTC_2667 digitoxin 100 µM -1.78594012730336 0.0303138078587425 no 3227 0.0370544764441461 4605 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2664 lyso-paf C-16 73.48 µM -1.78696645741216 0.0302404901228375 no 3228 0.0369714550282354 4620 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_62 0180-0423 3.232 µM -1.79181096424493 0.0298963955632803 no 3229 0.0365816259543248 4569 30102 YGL099W LSG1
SGTC_1158 4092-0494 91.8 µM -1.79803427697406 0.0294591391081206 no 3230 0.0360857880427337 4674 1148199
SGTC_2473 5854593 8.94 µM -1.79875738476704 0.0294086788481418 no 3231 0.0360285335545533 4614 2872951
SGTC_3114 9122766 49.47 µM -1.80036820919877 0.0292965294757194 no 3232 0.0359012585704387 4612 17176985
SGTC_1681 tripelennamine 100 µM -1.80834755343095 0.0287462139117068 no 3233 0.0352762125500298 4555 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_622 1348-1566 26.3 µM -1.80859216591882 0.0287294803151762 no 3234 0.0352571932333137 4631 7340407
SGTC_1340 1486-1359 257 µM -1.81188717133902 0.0285048619386845 no 3235 0.0350018160098364 4605 4309068
SGTC_265 mycophenolic acid 32.932 µM -1.81407626780095 0.0283564418792697 no 3236 0.0348329923514093 4671 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2863 9028737 58.44 µM -1.82306793206781 0.0277535395341448 no 3237 0.0341465513829485 4634 6460917
SGTC_375 3970-0961 9.27 µM -1.82688824670594 0.0275006354837412 no 3238 0.0338582868906053 4620 2898222
SGTC_1676 st018489 23.4 µM -1.82830038404443 0.0274076399624173 no 3239 0.0337522411147084 4586 3696235
SGTC_1010 4112-3296 15.2 µM -1.83198246782341 0.027166391044631 no 3240 0.0334770163500882 4645 704384
SGTC_1835 st008666 49.2 µM -1.84910567416164 0.0260676435658281 no 3241 0.0322212776115069 4615 690455
SGTC_2118 5526350 200 µM -1.85064475712543 0.0259707318061306 no 3242 0.0321103381579429 4633 743594
SGTC_2115 tiliquinol 12.7705 µM -1.85367490219908 0.025780812746597 no 3243 0.0318928422240124 4616 71208 A bioactive hydroxyquinoline.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.86283201106253 0.0252139273712808 no 3244 0.0312429523885688 4641 2724278 An inhibitor of dopamine biosynthesis.
SGTC_639 0833-0042 114 µM -1.86646294779993 0.0249920588827311 no 3245 0.0309883116548191 4666 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2238 6671620 73.2395 µM -1.86973263671567 0.0247936673428497 no 3246 0.0307604774889291 4563 729941
SGTC_451 chloral hydrate 100 µM -1.87451013474813 0.0245061644031663 no 3247 0.0304300732498311 4634 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1160 4092-0570 10.5 µM -1.87800406639333 0.024297680579513 no 3248 0.0301903044027509 4655 4994975
SGTC_1862 st057513 3.81 µM -1.88079178600335 0.0241324066969644 no 3249 0.0300001239827111 4655 5393163
SGTC_655 k060-0012 42 µM -1.88125322936361 0.0241051406821995 no 3250 0.0299687399902451 4665 5994525
SGTC_1263 0774-1208 64.8 µM -1.88272107504958 0.024018579865077 no 3251 0.0298690889027693 4629 906585
SGTC_1225 1216-0074 20.6 µM -1.88878203668778 0.0236639177888333 no 3252 0.0294605203702092 4646 4241466
SGTC_2670 beta-carotene 100 µM -1.8894354027676 0.0236259498598801 no 3253 0.0294167554223637 4664 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1223 0764-0573 147 µM -1.89802288109074 0.0231316644339679 no 3254 0.0288465339723408 4656 1609797
SGTC_1841 st054148 70 µM -1.90284117289088 0.0228581624530992 no 3255 0.0285306364721685 4672 675442
SGTC_1871 st057448 67.3 µM -1.90316335556188 0.0228399719035141 no 3256 0.0285096165354433 4649 691747
SGTC_547 1120-0019 610 nM -1.91268627126309 0.0223077871889371 no 3257 0.0278941138872915 4642 3676939
SGTC_44 0929-0055 61.211 µM -1.92154636985196 0.0218220756852994 no 3258 0.0273314311795288 4516 1379590
SGTC_166 k072-0058 166.424 µM -1.93043050912699 0.0213440450245932 no 3259 0.0267767588708385 4552 5846229
SGTC_2717 st081029 62.2815 µM -1.9322681926899 0.0212462775315958 no 3260 0.0266632060832594 4654 5292846
SGTC_2782 7736369 71.43 µM -1.94802665899792 0.020423349157089 no 3261 0.0257058866771709 4635 2950836 YOL077C BRX1
SGTC_3212 9128307 49.47 µM -1.94912918082117 0.020366799108971 no 3262 0.0256399998154359 4563 27243542
SGTC_1616 st002734 56.1 µM -1.95060352005195 0.0202913854130164 no 3263 0.0255521140793178 4661 4026101
SGTC_1169 aniline yellow 25.8 µM -1.95075812152165 0.0202834911477957 no 3264 0.0255429128759175 4638 6051 A DNA damaging agent.
SGTC_938 3126-1755 342 µM -1.95941339284552 0.019845669641421 no 3265 0.0250321967376621 4667 1777771
SGTC_2451 5856223 45.7 µM -1.9628582146033 0.0196736604293097 no 3266 0.0248313256200656 4655 2179896
SGTC_377 3970-0964 33.1 µM -1.97236976900325 0.019205282258336 no 3267 0.024283705151246 4668 16481235
SGTC_1954 st077032 68.9 µM -1.9842537260325 0.0186334296203119 no 3268 0.0236137809671204 4621 698907
SGTC_2669 eugenol 100 µM -1.98516873281535 0.0185900070905473 no 3269 0.0235628508869299 4709 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_401 neomycin 50 µM -1.9971794684103 0.0180279666904771 no 3270 0.0229028453004607 4688 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3026 9090633 49.47 µM -1.99895609236627 0.0179460724700211 no 3271 0.0228065523972756 4687 25236842
SGTC_2150 5556613 200 µM -1.99994420366758 0.0179006625065837 no 3272 0.0227531446141856 4704 743190
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -2.00080467897664 0.0178611980859943 no 3273 0.0227067214980301 4710 91467 include heat shock
SGTC_1974 st069448 26.9 µM -2.0040103048304 0.0177148293732599 no 3274 0.0225344782865808 4677 6323587 YNR016C ACC1
SGTC_72 0744-0168 198.391 µM -2.00427446176822 0.0177028137556713 no 3275 0.0225203339893927 4595 677577
SGTC_1969 st069479 40.1 µM -2.0055386870603 0.01764540460586 no 3276 0.0224527445818209 4686 3895485
SGTC_2841 9004761 38.96 µM -2.01870905254312 0.0170567216875076 no 3277 0.0217587342747008 4625 2991039
SGTC_2127 5253358 187.912 µM -2.02147509349255 0.016935242633032 no 3278 0.0216153040362396 4626 20612
SGTC_974 1326-0144 138 µM -2.02763590379369 0.0166673283146775 no 3279 0.0212987108979014 4687 5411856
SGTC_247 mechlorethamine 29.705 µM -2.02918393918634 0.0166005820355101 no 3280 0.0212197794055883 4691 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_556 4058-0063 51.5 µM -2.02932804843395 0.0165943801653248 no 3281 0.0212124441430674 4690 6615692
SGTC_790 1575-0012 79.1 µM -2.03565794529432 0.0163239169013319 no 3282 0.020892357402271 4697 378741 YLR208W SEC13
SGTC_2708 st078559 56 µM -2.03669979969703 0.0162797644249777 no 3283 0.020840067311059 4670 17250902
SGTC_540 1187-0821 17.3 µM -2.05896406875893 0.0153603918157118 no 3284 0.0197488403462115 4643 847520
SGTC_3133 9127736 49.47 µM -2.06791186173928 0.0150036647782567 no 3285 0.0193241559046081 4685 27243420
SGTC_599 1935-0052 86.5 µM -2.08416069416929 0.0143740506372613 no 3286 0.018572776367626 4707 9557311
SGTC_2461 5755302 26.15 µM -2.08871517987127 0.0142017071796185 no 3287 0.0183666847888137 4689 2788904
SGTC_91 0417-1751 58.384 µM -2.11130129621091 0.0133731028896776 no 3288 0.0173732113556133 4736 6795624
SGTC_338 4055-0136 114 µM -2.1154128891256 0.0132268424604501 no 3289 0.0171973861044455 4699 2900563
SGTC_2849 9019321 12.99 µM -2.12024477218715 0.0130567276098057 no 3290 0.0169927042349429 4701 16489627
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.12250176519772 0.0129779164216141 no 3291 0.0168978123094906 4681 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_392 N-ethylmaleimide 8.33 µM -2.12909258966628 0.0127501234367137 no 3292 0.0166233003728718 4706 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_97 0535-0701 19.132 µM -2.13691024258445 0.0124844209905391 no 3293 0.016302646380768 4642 2832013 YGL099W LSG1
SGTC_2617 dihydrotanshinone i 20.83 µM -2.14841310359066 0.0121021893043232 no 3294 0.0158404763717798 4673 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2576 guaiol 23.12 µM -2.15025942759833 0.0120417918260735 no 3295 0.0157673498798308 4651 227829
SGTC_519 k048-0011 62.8 µM -2.16725663024396 0.0114979439509776 no 3296 0.0151076457330614 4706 6836379
SGTC_2467 5474540 200 µM -2.1716468435116 0.0113609887983564 no 3297 0.0149411554230951 4713 5413519
SGTC_2556 citropten 84.59 µM -2.18526988636789 0.0109449952629384 no 3298 0.0144345319998409 4694 2775 A potential DNA crosslinker.
SGTC_264 promethazine 12.5 mM -2.20054127470638 0.010494482587196 no 3299 0.0138842574426868 4629 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1525 8-methoxypsoralen 92.5 µM -2.21384927086917 0.0101151544497496 no 3300 0.0134195746997475 4729 4114 Related to psoralen; DNA damaging agent.
SGTC_148 3253-0744 288.01 µM -2.22152060897566 0.00990197338279316 no 3301 0.0131578602123591 4658 6893655
SGTC_2840 9008771 71.43 µM -2.22265694407284 0.00987073135802159 no 3302 0.0131194706369521 4702 2992978
SGTC_2474 5321570 43.32 µM -2.23407689670622 0.00956150388310299 no 3303 0.0127390069319255 4731 2841384
SGTC_933 2914-0560 114 µM -2.24613678170464 0.00924417462630477 no 3304 0.0123476240082828 4723 463887
SGTC_3348 9149464 3.537 µM -2.25275781173916 0.00907390662085613 no 3305 0.0121372117915439 4711 1951442
SGTC_862 0452-0056 10.2 µM -2.25659971210506 0.00897637175542463 no 3306 0.0120165491906172 4715 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2866 9034245 58.44 µM -2.27871146399414 0.00843267628620504 no 3307 0.0113421114126023 4752 6462273
SGTC_66 0109-0187 42.4 µM -2.28253978497847 0.00834153799223209 no 3308 0.0112287456970495 4596 759417
SGTC_371 0195-0006 7.36 µM -2.32088847174878 0.00747526648546542 no 3309 0.0101464319500519 4631 3928593
SGTC_1917 st066507 28.5 µM -2.3218391340931 0.00745483786448231 no 3310 0.0101207995898013 4650 3156428
SGTC_1272 0839-0021 27 µM -2.33899688340706 0.00709449995994543 no 3311 0.00966779739399358 4776 5027250
SGTC_409 arachidonic acid 100 µM -2.34183230468989 0.00703645525233884 no 3312 0.00959466740443923 4745 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_860 0443-0016 25.1 µM -2.36522008482187 0.00657344747979376 no 3313 0.00900967954947079 4757 5337942
SGTC_3050 9093513 49.47 µM -2.37697718855501 0.00635103192088828 no 3314 0.00872758377889792 4726 25236664
SGTC_2847 9005661 71.43 µM -2.38001543720304 0.00629464989013868 no 3315 0.00865595639706764 4767 2991449
SGTC_3118 9124250 49.47 µM -2.41430416949008 0.00568840303085506 no 3316 0.00788264758236311 4740 1504786
SGTC_1475 4092-1048 11.7 µM -2.42535274737402 0.00550441233207594 no 3317 0.00764675930790325 4749 2881759
SGTC_3240 9133527 49.47 µM -2.43618925254571 0.00532910913048407 no 3318 0.00742145826444379 4762 17617455
SGTC_2859 9028643 45.46 µM -2.46467418883895 0.00489175576554671 no 3319 0.0068568943975832 4669 17151580
SGTC_645 0845-0943 5.41 µM -2.47502341750154 0.00474095927508346 no 3320 0.00666137199918371 4765 1885106
SGTC_2983 9022671 12.99 µM -2.48135025152473 0.00465082738905318 no 3321 0.00654428464369917 4756 6405161
SGTC_2843 9000894 45.46 µM -2.5006971964407 0.00438462256870962 no 3322 0.00619745530212251 4777 2242070
SGTC_1372 2752-0194 270 µM -2.51936600076917 0.0041407423465096 no 3323 0.00587831899302535 4738 823334
SGTC_2114 5491910 81.25 µM -2.55535090747218 0.00370463915215182 no 3324 0.00530403975597594 4767 2849228
SGTC_3213 9129884 49.47 µM -2.55687601344636 0.00368710176636866 no 3325 0.00528084275111273 4734 17190742
SGTC_2716 st080858 38.6235 µM -2.55740412877665 0.00368104628375432 no 3326 0.0052728311266252 4756 5296050
SGTC_512 prima-1 270 µM -2.56530918219393 0.0035914654198383 no 3327 0.00515419518453647 4776 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2814 7977482 42.97 µM -2.57241267039823 0.00351264241932371 no 3328 0.00504962157216085 4749 6456762
SGTC_1750 st081859 2.357 µM -2.57915536693373 0.00343926372428377 no 3329 0.00495211149885684 4712 5291695
SGTC_504 lovastatin 124 µM -2.58193007424307 0.00340946954543077 no 3330 0.00491247448154076 4748 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2148 5546263 113.568 µM -2.62562389635669 0.00296990976700364 no 3331 0.00432451629004883 4781 792097
SGTC_2707 st078556 66.6 µM -2.68876472847805 0.00242468555592564 no 3332 0.0035858472646539 4765 17250899
SGTC_391 gliotoxin 8.33 µM -2.72746642067229 0.00213700246893695 no 3333 0.00319113765936112 4783 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2608 thymoquinone 42.66 µM -2.7324342389432 0.00210240827338076 no 3334 0.00314341101884262 4745 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_766 1391-0721 126 µM -2.78243007759595 0.00178149523138974 no 3335 0.00269767449528691 4786 1020919 YIL115C NUP159
SGTC_167 3672-0051 66.205 µM -2.82382677599935 0.00155023684345166 no 3336 0.00237270122114457 4748 3237971
SGTC_1417 3966-0327 90.4 µM -2.86821605884951 0.0013329471305757 no 3337 0.00206396766582151 4804 651118
SGTC_2522 biochanin a 4.94 µM -2.89185289051847 0.00122895863963359 no 3338 0.00191488612370528 4775 5280373 A possible chelator.
SGTC_2019 4016004 108 µM -2.90389237180553 0.00117889556342815 no 3339 0.00184277416546591 4769 45595336
SGTC_1162 k048-0130 20.1 µM -2.92804126923738 0.00108406365412667 no 3340 0.00170552383086565 4786 6797406
SGTC_546 peri-Naphthalide 147 µM -2.93468616264425 0.00105922508707696 no 3341 0.00166942600102592 4784 223824 A penicillin ester.
SGTC_2508 celastrol 40.54 µM -3.01057304254272 0.000810305108312005 yes 3342 0.00130377611628146 4782 122724 Celastrol is a natural product and antioxidant.
SGTC_2107 5363541 170.161 µM -3.06035090004003 0.00067757734107741 yes 3343 0.00110538903074004 4781 244052
SGTC_1492 4158-0558 28.5 µM -3.06367490046446 0.000669471520750826 yes 3344 0.00109318180432047 4803 3967268
SGTC_3117 9124945 49.47 µM -3.11015667408407 0.000565108486293756 yes 3345 0.000934940662497266 4788 17592065
SGTC_2543 pimpinellin 60.67 µM -3.11765944353133 0.000549746350677679 yes 3346 0.000911466563203972 4766 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3116 9124943 49.47 µM -3.13558724915814 0.000514589201201571 yes 3347 0.000857552013241416 4802 41905195 YPL160W CDC60
SGTC_2960 9079389 5.97 µM -3.1418689602688 0.000502771087045609 yes 3348 0.000839365747952138 4785 16457355
SGTC_2439 5492030 7.2 µM -3.14990021973998 0.000488027384229477 yes 3349 0.000816631168480255 4796 5722370
SGTC_1983 st071813 46.9 µM -3.21250721025055 0.000386101464869912 yes 3350 0.000657909228097187 4802 11838595
SGTC_1916 st067606 49.2 µM -3.28701011981729 0.000290645447921003 yes 3351 0.000506285974353815 4767 19590279
SGTC_791 1348-1292 225 µM -3.44488835218686 0.000156260728157579 yes 3352 0.000285647655881966 4799 5437054
SGTC_518 1021-0119 62.6 µM -3.45056528892825 0.000152739750546427 yes 3353 0.000279706919882789 4788 1097762
SGTC_1220 1838-0075 193 µM -3.50995621336763 0.000120099701149488 yes 3354 0.000224090245537801 4794 5529645
SGTC_2711 st079103 59.1 µM -3.69090848274095 5.64557201158915e-05 yes 3355 0.000111727265003136 4806 54693780
SGTC_3119 9125183 49.47 µM -3.91414095963608 2.12347402046012e-05 yes 3356 4.53633129993241e-05 4805 22695334