SGTCid condition conc unit AKR1|YDR264C.score AKR1|YDR264C.strain.pval AKR1|YDR264C.strain.significant AKR1|YDR264C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_121 0557-0495 61.343 µM 7.87257656818122 8.2255677898537e-12 yes 1 1.73705457775635e-15 10 3104427
SGTC_1636 st007707 68.9 µM 7.17624911301557 4.88947793222069e-10 yes 2 3.58249750508299e-13 14 403051
SGTC_2800 7887935 81.82 µM 6.32784893868677 4.26044859009576e-08 yes 3 1.24301166237477e-10 4 2961002
SGTC_1135 dihydrocapsaicin 536.708 nM 5.87143155223039 3.74207792258933e-07 yes 4 2.16023986808381e-09 6 107982 A Capsaicinoid.
SGTC_1511 0906-3109 28.5 µM 5.80940716902608 4.96553067421183e-07 yes 5 3.13472225994819e-09 13 2882180
SGTC_2084 5306078 60.6385 µM 5.80679676784631 5.02467451695671e-07 yes 6 3.1839676755027e-09 3 679340
SGTC_65 0798-0905 34.986 µM 5.70845836371666 7.81929556415287e-07 yes 7 5.70020290411511e-09 39 3602145
SGTC_2450 5739737 12.93 µM 5.69529023787594 8.29163949473479e-07 yes 8 6.15811117851501e-09 5 2262825
SGTC_3244 9134489 49.47 µM 5.5144055841889 1.83102019141161e-06 yes 9 1.74980357506377e-08 7 16584271
SGTC_562 3772-2733 112 µM 5.42683157672774 2.66284682120347e-06 yes 10 2.86816049160932e-08 42 2876874 YIL048W NEO1
SGTC_637 1181-0519 7.26 µM 5.39291043164482 3.07370884656269e-06 yes 11 3.46627570319078e-08 59 6252091 YGR060W ERG25
SGTC_863 0466-0191 129 µM 5.18826334992286 7.16977452957615e-06 yes 12 1.06132141926489e-07 40 765160 YPR165W RHO1
SGTC_2376 9072922 81.32 µM 5.17067439472201 7.69966479635556e-06 yes 13 1.16625339302329e-07 7 17087968
SGTC_2772 vinpocetine 57.06 µM 5.08310075847033 1.09426692930798e-05 yes 14 1.85661297495088e-07 9 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1970 st070122 35.8 µM 5.03203909388895 1.33954492018339e-05 yes 15 2.42645134956318e-07 12 102928
SGTC_625 k213-0058 121 µM 4.85389039609356 2.67083588425335e-05 yes 16 6.05313316970453e-07 62 3655420
SGTC_1156 4092-0367 4.88 µM 4.83271999778512 2.89443650441843e-05 yes 17 6.73400749162821e-07 7 1357585
SGTC_1090 efavirenz 20.7 µM 4.81025891078574 3.1509965758861e-05 yes 18 7.53674580464314e-07 9 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_549 1661-1316 519 µM 4.78519046965879 3.46271651642091e-05 yes 19 8.54126289109713e-07 7 2857282
SGTC_2999 9069765 71.4286 µM 4.77764003268453 3.56218039307671e-05 yes 20 8.86822640432948e-07 11 2097066
SGTC_2384 9036245 200 µM 4.76116033745793 3.78873781568605e-05 yes 21 9.62415215509972e-07 19 6462766
SGTC_2752 diclazuril 33.15 µM 4.75118640703506 3.93240454672424e-05 yes 22 1.01113298302961e-06 82 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1627 st003713 25.6 µM 4.69649497157464 4.81623835730078e-05 yes 23 1.32331873856738e-06 49 16195070 YER133W GLC7
SGTC_708 3448-5400 146 µM 4.55827191025065 7.95887354779577e-05 yes 24 2.57881181987508e-06 25 3462195
SGTC_2026 5148700 152 µM 4.49033999528197 0.000101335466288221 yes 25 3.55547877023576e-06 10 79838
SGTC_1051 3253-3903 78 µM 4.4684521940712 0.00010945640861248 yes 26 3.93938077530636e-06 13 5509239
SGTC_1127 asiatic acid 681.4 nM 4.45761454358721 0.00011369998378044 yes 27 4.14383771945421e-06 13 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1103 duloxetine 36.1 µM 4.43718013259929 0.000122124471551172 yes 28 4.55725087981308e-06 18 60835 A selective serotonin reuptake inhibitor.
SGTC_2105 5350118 200 µM 4.42603922676564 0.000126960736385936 yes 29 4.7989539006548e-06 18 2133313
SGTC_1956 st077085 54 µM 4.35573208097646 0.000161872596642746 yes 30 6.63114569911304e-06 13 24208685
SGTC_205 1486-1330 71.903 µM 4.32510711435432 0.000179731421398363 yes 31 7.62288816770178e-06 14 4118834
SGTC_825 1988-2224 89.6 µM 4.26944344162069 0.000216995139417544 yes 32 9.79806653617624e-06 28 1180859
SGTC_2526 patulin 37.61 µM 4.2525875102282 0.000229630079630057 yes 33 1.05657298779382e-05 76 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_338 4055-0136 114 µM 4.23955304959694 0.000239867624778453 yes 34 1.11982631528453e-05 5 2900563
SGTC_1263 0774-1208 64.8 µM 4.1601335911965 0.000312028409674556 yes 35 1.59030749855705e-05 41 906585
SGTC_2887 9044784 58.44 µM 4.14803365631897 0.000324650513854006 yes 36 1.67671554424315e-05 23 6465546
SGTC_585 0kpi-0023 191 µM 4.11244098816207 0.000364585376510897 yes 37 1.95748780909435e-05 16 64601
SGTC_2794 7785382 27.27 µM 4.10762587012241 0.000370325508971851 yes 38 1.99873468813256e-05 32 2205081
SGTC_2953 9074162 66.49 µM 4.10365449243938 0.000375122857448018 yes 39 2.03337332601115e-05 20 16451992
SGTC_1500 4488-1866 171 µM 4.05471981313645 0.000439167888788305 yes 40 2.50972154139342e-05 15 2900003
SGTC_1214 0358-0031 63.7 µM 4.0519010908305 0.000443149356098372 yes 41 2.54015713996111e-05 16 4301366
SGTC_1909 st060837 51.5 µM 4.04943255770115 0.000446663635159377 yes 42 2.56709853849985e-05 49 678937
SGTC_208 k072-0098 12.366 µM 3.99276094108533 0.000534800838805595 yes 43 3.26542009163181e-05 42 5948901
SGTC_3311 9131146 2.8755 µM 3.95710157700053 0.000598233826121036 yes 44 3.79323381841294e-05 121 4900406 YPR165W RHO1
SGTC_379 3970-0972 5.9 µM 3.9418209496508 0.000627486738083146 yes 45 4.04326675557972e-05 38 2898042 YBL034C STU1
SGTC_776 4476-4378 112 µM 3.93410877333408 0.00064274711261189 yes 46 4.17529814316921e-05 18 2892008
SGTC_270 tamoxifen 5.46 µM 3.92184781740891 0.00066771504840953 yes 47 4.39362438447251e-05 29 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_221 trifluoperazine 10.304 µM 3.91882044662822 0.00067401616405853 yes 48 4.44916847222135e-05 213 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2243 6634756 200 µM 3.90632364280433 0.00070061171176898 yes 49 4.68554900868993e-05 21 885676
SGTC_1097 itavastatin 7.23 µM 3.9053780836796 0.000702662907878685 yes 50 4.70390898545778e-05 22 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1931 st074438 57.1 µM 3.8884288453263 0.00074038278111016 yes 51 5.0447619919345e-05 18 2787313
SGTC_317 4495-0002 170 µM 3.87977067111767 0.000760363095661254 yes 52 5.22774976441502e-05 10 15991618
SGTC_3211 9128781 49.47 µM 3.86740587192569 0.000789759147429762 yes 53 5.49996328386098e-05 64 17194361
SGTC_1656 st012921 11 µM 3.83684003666159 0.000866972902316624 yes 54 6.23137961097176e-05 34 6732821
SGTC_1680 diphenhydramine 100 µM 3.83307560207365 0.000876948109772467 yes 55 6.32755196738914e-05 33 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1056 3448-1962 115 µM 3.81721661096681 0.000920141575047839 yes 56 6.74828353053213e-05 26 715507
SGTC_2289 7946404 165.07 µM 3.79089687930228 0.000996160718360638 yes 57 7.50521351394429e-05 100 1246120 YPR165W RHO1
SGTC_1939 st074455 53.6 µM 3.77919854465885 0.00103176473270543 no 58 7.86669698685709e-05 33 1644229
SGTC_2155 5570423 76 µM 3.77360229132561 0.00104920652103153 no 59 8.0453600144338e-05 13 797402
SGTC_1130 3454-2858 15.9 µM 3.76121270116555 0.00108878714406983 no 60 8.45457813200667e-05 98 715628 YIL048W NEO1
SGTC_1402 3909-7673 35.9 µM 3.74738158054448 0.00113458671884829 no 61 8.93450751019137e-05 24 5328014
SGTC_1253 0550-0034 176 µM 3.69170304845156 0.00133736979767009 no 62 0.000111378728265967 27 5969915
SGTC_2311 7694451 200 µM 3.67645205648269 0.00139842301998139 no 63 0.00011825013896511 27 2163142
SGTC_354 2783-3500 4.88 µM 3.66019245779797 0.00146630870037146 no 64 0.00012601294047655 56 6740761
SGTC_1625 st003711 30.1 µM 3.6207167411726 0.00164381762325605 no 65 0.000146894010558118 46 24207034 YER133W GLC7
SGTC_164 4100-3994 89.624 µM 3.61207521009151 0.00168519780874131 no 66 0.000151878216874458 43 4615967
SGTC_402 epigallocatechin gallate 10 µM 3.60771534372429 0.00170643313145629 no 67 0.000154452563403663 40 65064 An antioxidant.
SGTC_1018 4259-0013 28.1 µM 3.59738429206856 0.00175772783975334 no 68 0.00016071670462112 32 6801262
SGTC_85 0868-0259 160.055 µM 3.58043487770001 0.00184492980355226 no 69 0.000171511414911695 19 83173
SGTC_2989 9073649 71.4286 µM 3.55585263708616 0.00197840002271611 no 70 0.000188377611633034 56 21367202
SGTC_1116 jasmonic acid 1.58368 µM 3.54289785372236 0.0020522124683082 no 71 0.000197877980459016 30 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2907 7721985 69.9 µM 3.52032717086815 0.00218680646105174 no 72 0.000215507392053916 40 3267881
SGTC_2460 5552655 174.22 µM 3.52028078348749 0.00218709113168224 no 73 0.00021554508881412 42 5401989
SGTC_3115 9123671 49.47 µM 3.5150010611386 0.00221971213985646 no 74 0.000219876115560891 8 3286988
SGTC_2096 5468907 200 µM 3.51434204302861 0.00222381471747794 no 75 0.000220422383675078 18 759785
SGTC_3114 9122766 49.47 µM 3.49410337547365 0.00235320045030301 no 76 0.00023782839896371 32 17176985
SGTC_330 1488-0319 80.1 µM 3.48502468388489 0.00241342437066096 no 77 0.000246045821960575 21 6846614
SGTC_901 1112-0062 60.1 µM 3.47648220195831 0.00247136119333502 no 78 0.000254018973720388 17 1908457
SGTC_2124 5246320 200 µM 3.47147446160636 0.00250590668440082 no 79 0.000258804281631746 33 579342
SGTC_554 4483-2211 187 µM 3.46582463440896 0.00254540528755864 no 80 0.000264303970573584 27 747107
SGTC_1227 3909-8010 46.6 µM 3.45921670635229 0.00259231551142557 no 81 0.000270874419705394 35 15982272
SGTC_821 1114-0266 29.2 µM 3.44252022086807 0.00271434529130442 no 82 0.000288160388485788 38 3123235
SGTC_49 0717-0965 32.132 µM 3.42728655220036 0.00283018282198462 no 83 0.000304822686150716 40 5889349 YGL099W LSG1
SGTC_2091 4-phenylthiadiazole 200 µM 3.42386680222877 0.00285679193368326 no 84 0.000308684363484191 31 270010
SGTC_1859 st055998 20 µM 3.41552757460873 0.00292262797483614 no 85 0.000318292919025781 43 676301
SGTC_1565 sinapyl alcohol 95.1 µM 3.41091941034953 0.00295959206823942 no 86 0.000323721123618826 54 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2629 bisabolol 100 µM 3.40156346026015 0.00303593910174717 no 87 0.000335007852174725 39 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2833 9001315 45.46 µM 3.39176917488746 0.00311775949638448 no 88 0.000347214575801339 80 2989378
SGTC_844 0330-0132 15.3 µM 3.38871842322803 0.00314364762013197 no 89 0.000351100389128946 27 2828079
SGTC_1957 st077035 62.4 µM 3.38840721730005 0.00314629930281889 no 90 0.000351499042635729 29 705593
SGTC_1856 st057054 55.7 µM 3.37173867234042 0.00329130209137819 no 91 0.000373476434416194 42 1266018
SGTC_544 k015-0020 52.4 µM 3.3615927869842 0.00338247830911132 no 92 0.000387471576044951 26 3008304
SGTC_2194 5927483 104.545 µM 3.34035411353133 0.00358072630745337 no 93 0.000418358137841002 35 760979
SGTC_275 trichlorophene 5.69 µM 3.32374983743014 0.00374291368587514 no 94 0.000444079140198333 265 62616
SGTC_79 0052-0007 94.094 µM 3.31753282705102 0.0038053154728005 no 95 0.000454081215577405 60 2801472
SGTC_3098 9119039 49.47 µM 3.30406098995121 0.0039437463609141 no 96 0.000476475490756661 59 17161528
SGTC_258 haloperidol 50.781 µM 3.28082291149611 0.00419316275910509 no 97 0.000517523542880884 51 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2103 5378138 10 µM 3.25006678599483 0.00454493279430656 no 98 0.000576889545103482 43 244142
SGTC_1723 st034307 2.5525 µM 3.20948411116084 0.00504931724836087 no 99 0.000664866978600148 54 867466
SGTC_2784 7567673 72.73 µM 3.20261086896919 0.00513951184263558 no 100 0.000680939333116079 63 3471247
SGTC_2782 7736369 71.43 µM 3.20041119250275 0.00516867864616138 no 101 0.000686158263426157 77 2950836 YOL077C BRX1
SGTC_3038 9091290 49.47 µM 3.19141948283135 0.005289442593474 no 102 0.000707877826258674 46 25236843
SGTC_450 aminopyrene 156 nM 3.18822439602425 0.00533295499447209 no 103 0.000715746998696811 67 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_390 dec-rvkr-cmk 16.7 µM 3.17188331280433 0.00556051128357728 no 104 0.000757269241491051 65 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_514 4466-0038 2.65 nM 3.14628005489151 0.00593441163804655 no 105 0.000826807915544127 215 5722064
SGTC_2883 9059145 45.46 µM 3.14568850996702 0.00594330773561243 no 106 0.000828481873196565 29 16476510
SGTC_206 4546-0025 72.014 µM 3.1423335394552 0.0059939863769867 no 107 0.00083803493042591 118 6620745 YIL048W NEO1
SGTC_2993 9054257 71.4286 µM 3.13479595492079 0.00610924520443848 no 108 0.000859868422808429 89 6470217 YGL055W OLE1
SGTC_3202 9113761 49.47 µM 3.12854527448203 0.00620631073912882 no 109 0.00087836972266728 90 4798415
SGTC_2783 7738165 71.43 µM 3.11810933041534 0.00637141475639708 no 110 0.000910076351281993 66 17201110
SGTC_521 r062-0005 13.8 µM 3.11770248486184 0.00637792933831861 no 111 0.000911333475241989 47 2832033
SGTC_983 1491-0821 12.2 µM 3.11308519048215 0.00645227752104176 no 112 0.000925712837450424 34 46495113
SGTC_2945 9067681 61.76 µM 3.10656595789775 0.00655855631608245 no 113 0.000946370394619243 36 16456930
SGTC_414 piperonyl butoxide 100 µM 3.10213789652165 0.00663162414736815 no 114 0.000960642189930628 33 5794 A potent inhibitor of cytochrome P450.
SGTC_3055 9094636 49.47 µM 3.0953464250484 0.00674508935734601 no 115 0.000982915729735399 38 25236176
SGTC_1035 k081-0041 55.2 µM 3.08411283418805 0.0069365373386877 no 116 0.0010208007414412 58 731709
SGTC_1003 4049-0218 100 µM 3.07670518905562 0.00706539195500808 no 117 0.00104651096992081 61 295161
SGTC_2117 5521686 200 µM 3.06830440101082 0.00721407411819833 no 118 0.00107638603603311 53 803312
SGTC_928 2764-0428 58.7 µM 3.03003262051437 0.00792690351009398 no 119 0.00122263663328497 108 662578
SGTC_1082 camptothecin 424.86 nM 3.02995478093303 0.00792841427540357 no 120 0.00122295177924418 91 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2499 avocadenofuran 51.48 µM 3.02809760535915 0.00796453481450799 no 121 0.00123049293087243 87 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1100 amiodarone 5.07 µM 3.01036194612174 0.00831683290390713 no 122 0.00130468269194466 54 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2475 5812728 15.03 µM 3.00328962735813 0.00846108831738598 no 123 0.00133539063173193 62 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2197 6588183 93.1375 µM 2.99101665557245 0.0087166392699097 no 124 0.00139025163638391 50 884136
SGTC_1941 st076221 61.8 µM 2.98436044193482 0.00885804750026858 no 125 0.00142085900381912 144 2828568
SGTC_14 0354-0009 295 µM 2.97323705947691 0.0090988484484911 no 126 0.00147338382050768 75 1713507
SGTC_633 0437-0093 97.7 µM 2.96901011279808 0.00919184602123252 no 127 0.00149380382020932 51 2831118
SGTC_2496 diffractaic acid 79.83 µM 2.9675723904349 0.0092236666046633 no 128 0.00150080795816157 60 94870 An apoptosis inducer which activates caspases.
SGTC_320 4092-0846 5.34 µM 2.96408609581846 0.00930122813292588 no 129 0.0015179166837546 94 1359356
SGTC_2998 9066762 71.4286 µM 2.96081599182128 0.00937449802738843 no 130 0.0015341259635458 79 4945196
SGTC_1652 st011932 78 µM 2.94245340042378 0.00979537962775857 no 131 0.00162811394539884 54 1551076
SGTC_2868 9035608 32.47 µM 2.93726046110496 0.00991735964007119 no 132 0.00165562934479948 60 6462614
SGTC_2790 5423970 71.43 µM 2.92824651297886 0.0101322444720175 no 133 0.00170439830944617 130 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2116 5511452 16.8835 µM 2.8979361714984 0.0108848899260861 no 134 0.00187813513465388 65 870744
SGTC_3350 9150499 3.57 µM 2.89744385554837 0.0108975059745029 no 135 0.00188108535104177 119 4910996 YPR165W RHO1
SGTC_2437 5741531 144.16 µM 2.87176479798039 0.0115734421996505 no 136 0.00204093322830209 89 2262990
SGTC_1093 fluphenazine 7.97 µM 2.85966703099359 0.0119043068661554 no 137 0.00212043010744036 72 6602611 An atypical antipsychotic.
SGTC_1933 st074711 15.9 µM 2.85616081391802 0.0120017199493397 no 138 0.00214398944222014 110 17250958
SGTC_957 1187-1561 14.1 µM 2.83823096455959 0.0125107426577932 no 139 0.00226821719590507 79 1538454
SGTC_2232 chlorophetanol 41.5365 µM 2.82804325810945 0.0128082149319435 no 140 0.00234167388218771 216 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3116 9124943 49.47 µM 2.80854631323964 0.013394598267395 no 141 0.00248828618939754 66 41905195 YPL160W CDC60
SGTC_2801 7907800 81.82 µM 2.80620249336303 0.0134666274772539 no 142 0.00250645896857778 104 6620925
SGTC_993 3909-8757 62.7 µM 2.80281223976146 0.0135714067849095 no 143 0.00253295762356158 75 4288324 YLR208W SEC13
SGTC_2071 5230951 39.92 µM 2.79636112917871 0.0137727293852989 no 144 0.00258408080791854 71 1799272
SGTC_2191 5911152 200 µM 2.78937726243285 0.0139935767795807 no 145 0.00264047544864189 73 2875902
SGTC_2818 7996756 12.99 µM 2.78159713846564 0.014243191956533 no 146 0.00270460700826542 63 2241621
SGTC_201 4262-0159 12.803 µM 2.77491725372948 0.0144605583121479 no 147 0.00276078771748555 90 1341029
SGTC_1390 3413-2614 145 µM 2.765218734335 0.0147812324538799 no 148 0.00284423188768632 89 3421432
SGTC_847 0342-0274 5.54 µM 2.75518653850522 0.0151193560025524 no 149 0.00293293408917487 78 18097
SGTC_1348 1493-0373 93.8 µM 2.75147964369368 0.01524596338416 no 150 0.00296633534525489 78 3010129
SGTC_3331 9141060 1.957 µM 2.7461000520559 0.015431320218409 no 151 0.00301541842192196 93 4906567 YPR165W RHO1
SGTC_5 0352-0601 109.883 µM 2.74025952715385 0.0156347459501287 no 152 0.00306953437448501 54 762456
SGTC_1781 st038725 66.3 µM 2.73423642403983 0.0158469366065148 no 153 0.00312625658839213 191 4270275 YIL048W NEO1
SGTC_1771 st048882 4.1505 µM 2.73414667953954 0.0158501168373246 no 154 0.00312710883998014 84 4580403
SGTC_1087 pterostilbene 9.05 µM 2.70627378649556 0.016864685204202 no 155 0.00340214612537924 103 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2835 9006588 71.43 µM 2.70116828964199 0.0170564207602433 no 156 0.00345481831720656 125 2345538
SGTC_1362 1611-0397 101 µM 2.68795280337063 0.0175613984107055 no 157 0.0035945778578296 89 27816
SGTC_187 1488-2104 32.728 µM 2.68790814337782 0.017563126321676 no 158 0.00359505863779676 99 2852859
SGTC_1055 3448-0672 86 µM 2.6797921299797 0.017879556776185 no 159 0.00368339457945436 114 748378
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.67801379356877 0.0179495370301661 no 160 0.00370300841764111 97 521171
SGTC_1185 1319-0113 81.3 µM 2.6776834100161 0.0179625638221867 no 161 0.00370666262493911 63 4672763
SGTC_1982 st072467 71.9 µM 2.67684150418209 0.0179957960313666 no 162 0.00371598915178311 131 3163533
SGTC_1669 st015249 58.4 µM 2.67465844490722 0.0180822113420488 no 163 0.00374027093083723 50 722793
SGTC_3166 9102297 49.47 µM 2.67095050451145 0.0182297990006942 no 164 0.00378183994169933 111 25237072
SGTC_1665 st014639 11.4 µM 2.66391858183051 0.0185125119340416 no 165 0.00386181269468783 104 981133 YIL048W NEO1
SGTC_840 0245-0196 390 µM 2.65585325310471 0.0188413605475235 no 166 0.00395540153366127 87 3827528
SGTC_666 0272-0154 136 µM 2.65454456016852 0.0188951859502585 no 167 0.00397077749658786 142 6870312
SGTC_1685 st024049 53.0905 µM 2.64302779345246 0.0193745261967028 no 168 0.004108414503749 73 1941139
SGTC_2357 9067248 200 µM 2.64224005830635 0.0194076867671055 no 169 0.00411798290863269 87 9150235
SGTC_3245 9134821 49.47 µM 2.63249435972259 0.0198219469471511 no 170 0.00423802151779947 104 17014901
SGTC_3059 1327-0034 3 µM 2.63051760627101 0.0199068819823285 no 171 0.00426274767475121 134 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3274 9138298 49.47 µM 2.62742164607251 0.0200405264015373 no 172 0.00430173265923915 102 17015756
SGTC_853 0419-0306 21 µM 2.61087884559203 0.0207676013264146 no 173 0.00451549408254509 73 762713
SGTC_2079 5212404 121 µM 2.60630246593883 0.0209726391951294 no 174 0.00457627995635513 72 758462
SGTC_1623 st003709 20.3 µM 2.59442369747656 0.0215128593596402 no 175 0.00473748210951232 188 16192618
SGTC_1513 0337-0559 19 µM 2.58753941490886 0.0218312910806354 no 176 0.0048332067976964 110 775073
SGTC_1937 st074714 47.2 µM 2.58279322173075 0.022053136450153 no 177 0.0049002020994429 116 17250970
SGTC_1837 st055472 66.5 µM 2.58059719568964 0.0221564247288883 no 178 0.00493147938680615 99 676091
SGTC_1137 ixabepilone 100 µM 2.55734741597565 0.0232752205102477 no 179 0.00527369095368728 149 154225 A novel microtubule stabilizer.
SGTC_445 e6 berbamine 66 µM 2.55518042086043 0.0233818788324356 no 180 0.0053066384965588 250 6610268 A calcium/calmodulin antagonist.
SGTC_3217 9129673 49.47 µM 2.54307168117098 0.0239854622828258 no 181 0.0054941342135409 139 17248312
SGTC_15 0266-0086 27.098 µM 2.54256534189448 0.0240109843250276 no 182 0.00550210119342442 185 1712902 YIL048W NEO1
SGTC_1778 st046819 58.9 µM 2.53604160194726 0.0243418596299911 no 183 0.00560567072279804 127 671715
SGTC_2070 5230947 200 µM 2.53463924743068 0.0244134828720066 no 184 0.00562815900263948 100 2835538
SGTC_194 1486-1323 56.904 µM 2.52585236517585 0.0248662985211884 no 185 0.00577089862686664 100 5178754
SGTC_1434 4073-0095 163 µM 2.52181126505798 0.0250769017469947 no 186 0.00583761656440273 80 24133745
SGTC_1168 k815-0004 80.5 µM 2.51988333075327 0.0251779022668249 no 187 0.0058696868893686 93 642433
SGTC_3285 9112818 20.8695 µM 2.51950042461422 0.025198002457505 no 188 0.00587607493140999 116 17017947 YPR165W RHO1
SGTC_2302 7771753 200 µM 2.5156665480172 0.0253999995010952 no 189 0.00594037644480671 172 2203047
SGTC_502 l-744,832 89.3 µM 2.49534838458299 0.0264932832356664 no 190 0.00629167587137461 134 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1629 st005085 44.9 µM 2.4940992787658 0.0265617591004744 no 191 0.00631386098566003 146 24207091
SGTC_1154 4088-0362 150 µM 2.49362948761078 0.0265875512427862 no 192 0.00632222275441989 143 6618304
SGTC_924 2046-0044 21.3 µM 2.48038864694718 0.0273231404630014 no 193 0.00656196242182047 102 3623589
SGTC_678 1218-2179 85.9 µM 2.47990829422514 0.0273501421708482 no 194 0.00657080885166183 47 6820081 YOR116C RPO31
SGTC_3209 9113616 49.47 µM 2.47987316543203 0.0273521177123456 no 195 0.00657145621573174 138 16649353
SGTC_1732 st034308 51.822 µM 2.47882922836239 0.0274108800472624 no 196 0.00659071996416708 126 830119
SGTC_1726 st035556 14.5795 µM 2.47401301500055 0.0276833454567451 no 197 0.0066802414740454 167 5919439
SGTC_1033 k072-0102 21.3 µM 2.47235548003137 0.02777763693837 no 198 0.00671129861333709 141 5965931
SGTC_207 4185-0010 4.486 µM 2.46867259986079 0.027988101468226 no 199 0.00678076166082235 207 3761753
SGTC_2555 cholic acid 100 µM 2.46493773191473 0.0282028915782786 no 200 0.00685185319782812 89 6708657 Influences liver metabolism.
SGTC_55 0767-0285 6.563 µM 2.46165781224189 0.02839264786019 no 201 0.00691482707501365 148 3116166
SGTC_2063 5246145 200 µM 2.45940602072818 0.0285235369734493 no 202 0.00695835641900955 132 711240
SGTC_872 0588-0139 234 µM 2.45936178337289 0.028526113361952 no 203 0.0069592139880863 152 2047100
SGTC_2893 9048488 25.97 µM 2.4557061258674 0.0287396892361421 no 204 0.00703040445742924 109 6467338
SGTC_1693 xanthone 101.9 µM 2.45566964273323 0.0287418273866914 no 205 0.00703111815930185 108 7020 An insecticide.
SGTC_174 3553-0389 74.3 µM 2.45266746022824 0.0289182287500262 no 206 0.00709006797605186 120 738071
SGTC_3155 9099265 49.47 µM 2.45149302840544 0.0289874801016232 no 207 0.00711324711630423 113 25236499
SGTC_2332 7982454 138.89 µM 2.45089598440835 0.0290227381051925 no 208 0.0071250562715001 187 2981748
SGTC_2642 cholecalciferol 100 µM 2.44875509020917 0.029149460198643 no 209 0.00716754414522893 91 9821465 A vitamin D precursor, similar to steriods.
SGTC_2890 9046729 58.44 µM 2.42706134666684 0.0304596535405506 no 210 0.00761084086367024 106 903329
SGTC_1539 benzyladenosine 56 µM 2.42615679515819 0.0305153266550619 no 211 0.00762983794004374 90 92208 A nucleotide analog.
SGTC_582 0987-0078 156 µM 2.42290648704078 0.0307160718588085 no 212 0.00769844475347978 238 1625765
SGTC_2334 9017922 200 µM 2.41511565043402 0.0312017033638187 no 213 0.0078651071168114 112 3163164
SGTC_1502 4534-4282 27.7 µM 2.40917329130597 0.0315763671288503 no 214 0.00799435208414474 102 3278949
SGTC_2109 5483026 200 µM 2.40690931961492 0.0317200845367335 no 215 0.00804408201401475 147 759335
SGTC_138 0850-0259 40.9225 µM 2.40398226364342 0.0319066953467997 no 216 0.00810878005069957 353 6813004
SGTC_1573 oleylamine 1.06 µM 2.39453068775446 0.0325154693934359 no 217 0.00832082539079142 154 5356789 An amine of the fatty acid oleic acid.
SGTC_700 3453-2283 142 µM 2.39314969038799 0.0326052162381491 no 218 0.00835221219836711 161 565664
SGTC_356 1634-0012 32.5 µM 2.39111239451182 0.03273798685782 no 219 0.00839870490612886 136 735457
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.38773154910192 0.0329593001178838 no 220 0.00847635991928465 66 88881 An O-methylated flavonoid and antioxidant.
SGTC_2881 9058953 51.95 µM 2.38292952465245 0.0332757631128574 no 221 0.00858774105289814 158 17122249
SGTC_2214 7179297 48.276 µM 2.37829349867971 0.0335836566134801 no 222 0.00869648792079599 68 769744
SGTC_473 2-arachidonoylglycerol 10 µM 2.37384720262623 0.0338811486579338 no 223 0.00880191682363633 127 5282280 An endocannabinoid.
SGTC_3130 9127414 49.47 µM 2.3737328529034 0.0338888280500147 no 224 0.00880464295471837 101 1494646
SGTC_2603 homopterocarpin 100 µM 2.37235438003754 0.0339815149566506 no 225 0.00883756443619422 181 101795 A weak amylase inhibitor.
SGTC_2379 9035213 200 µM 2.37165658061168 0.0340285135968564 no 226 0.00885427077584641 131 646551
SGTC_3264 9137442 49.47 µM 2.37150571047343 0.0340386821251649 no 227 0.00885788646459058 91 17015726
SGTC_1487 3970-0795 2.82 µM 2.35900867889005 0.0348896880977096 no 228 0.00916191360866696 121 3765103
SGTC_2871 9038510 12.99 µM 2.35851152032414 0.0349239009329894 no 229 0.00917419513158724 129 4945164
SGTC_595 3909-8003 73.7 µM 2.35460643987423 0.0351935946135605 no 230 0.00927116622329968 127 699517
SGTC_2852 9023854 51.95 µM 2.35073759311227 0.035462468461145 no 231 0.00936812086267763 136 19798528
SGTC_3145 9085516 49.47 µM 2.34903408671294 0.0355813902343224 no 232 0.00941109181142857 154 25236195
SGTC_1991 st073000 8.92 µM 2.34408780696167 0.0359285438236289 no 233 0.0095368401918516 218 4301969 YIL048W NEO1
SGTC_916 4466-0038 42 nM 2.33715604864019 0.0364197117946338 no 234 0.00971553577665792 236 5722064 YGL116W CDC20
SGTC_1011 4112-3381 17.4 µM 2.32584548764799 0.0372329395336402 no 235 0.0100133975004953 164 2877139
SGTC_1733 st037357 54.9 µM 2.3254908883085 0.0372586731170529 no 236 0.0100228632858948 180 1272339 YGL099W LSG1
SGTC_1349 flufenamic acid 69 µM 2.32360175378186 0.0373960142878444 no 237 0.0100734241784476 126 3371 A non-steroidal anti-inflammatory.
SGTC_888 0916-0002 6.97 µM 2.32134799475482 0.037560404507927 no 238 0.0101340349366723 148 2802138 YIL048W NEO1
SGTC_2697 mebhydrolin 72.4 µM 2.31483922757013 0.0380384721045403 no 239 0.010310866124519 222 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_581 0958-0271 211 µM 2.31428204867261 0.0380796263930832 no 240 0.0103261279160315 227 4591145
SGTC_2741 miltefosine 3.04 µM 2.31412261059457 0.0380914094725035 no 241 0.0103304987371114 121 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_228 caffeine 993.056 µM 2.30967685744939 0.0384211669119954 no 242 0.010453025493413 97 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2916 7875993 68.79 µM 2.30940233404445 0.0384416053429173 no 243 0.0104606328171239 164 1299250
SGTC_2531 methyl deoxycholate 70.07 µM 2.3079953473968 0.0385464954837301 no 244 0.010499697633404 156 16667744 Haematoxylin.
SGTC_2251 lansoprazole 556 µM 2.30403511530177 0.0388429814331366 no 245 0.0106103362382131 117 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2375 9072683 200 µM 2.30216523671582 0.0389836155224529 no 246 0.010662927798915 173 16798029
SGTC_1196 1588-0294 184 µM 2.30194311441744 0.0390003489176595 no 247 0.0106691901950798 126 6144269
SGTC_1805 st050013 60.3 µM 2.30062360764146 0.0390998734404399 no 248 0.0107064577279721 106 4037144
SGTC_1578 josamycin 24.2 µM 2.29670493947331 0.0393966604282639 no 249 0.0108178037433617 126 5282165 A P450 substrate.
SGTC_1830 st055982 50.3 µM 2.29542797160129 0.0394937687702586 no 250 0.0108543049336132 136 455313 An antimicrobial agent.
SGTC_13 0199-0087 65 µM 2.29525923953329 0.0395066147257545 no 251 0.0108591360249821 120 4589825
SGTC_658 3253-0951 102 µM 2.28478764806759 0.0403105151029611 no 252 0.0111626411407491 220 1184878
SGTC_2872 9044037 25.97 µM 2.273377737021 0.0412015215141654 no 253 0.0115017132867266 81 6465195
SGTC_1145 3546-0597 10.2 µM 2.27329535799064 0.0412080121286845 no 254 0.0115041935453973 174 875334
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.27060118083135 0.0414207426707898 no 255 0.0115855659634915 157 5282309
SGTC_468 gf-109203x 121 µM 2.27046363847825 0.041431626761648 no 256 0.0115897335398198 66 2396 A protein kinase C inhibitor.
SGTC_176 1486-1328 72.834 µM 2.26930630636131 0.0415233013456809 no 257 0.0116248526538183 228 22310231
SGTC_4 0960-0234 25.671 µM 2.26697584626556 0.0417084004114498 no 258 0.0116958506338715 131 6821112
SGTC_2416 tofa 880 nM 2.2659545408883 0.0417897289301515 no 259 0.0117270833543768 199 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_890 0929-0006 47.2 µM 2.26433071250994 0.0419193018982803 no 260 0.0117768909850062 143 1378169
SGTC_2981 9013952 38.96 µM 2.26301214784494 0.0420247555558223 no 261 0.0118174702265011 188 2996344
SGTC_1300 1094-0077 113 µM 2.26156337829503 0.0421408699738796 no 262 0.0118621963949552 147 5532636
SGTC_715 0868-0130 184 µM 2.26074230618907 0.0422067915585848 no 263 0.0118876095365772 115 2876258
SGTC_631 k072-0230 41.5 µM 2.25475578941226 0.0426899580918281 no 264 0.0120743308531376 148 5773147
SGTC_1430 4049-0248 69.1 µM 2.25107386139013 0.0429893374812287 no 265 0.0121904298184596 169 22774488
SGTC_2775 cyproheptadine 69.59 µM 2.24901875344487 0.043157175583391 no 266 0.0122556514797825 143 2913 A selective serotonin reuptake inhibitor.
SGTC_1809 st050081 57.6 µM 2.24884986280276 0.0431709921739103 no 267 0.0122610248758739 159 5036894
SGTC_3321 9137793 26.8275 µM 2.24292910587656 0.0436576191378378 no 268 0.0124506932531713 223 4904192
SGTC_1420 4'-methoxyflavone 42 µM 2.24149562403228 0.0437761001164025 no 269 0.0124969943331635 131 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_366 0181-0206 4.31 µM 2.24026333549541 0.0438781591739725 no 270 0.0125369160165084 220 274874
SGTC_1976 st070609 63.5 µM 2.2329069251783 0.0444914215959497 no 271 0.0127775414082118 141 682556
SGTC_2059 5238311 157 µM 2.23168680362588 0.0445938007398966 no 272 0.0128178350157442 177 703021
SGTC_1373 2887-0003 58.5 µM 2.22488642314809 0.0451678948040394 no 273 0.0130444318400302 175 776948
SGTC_197 4544-0043 41.561 µM 2.22486928106614 0.0451693494322893 no 274 0.0130450073821366 222 896523
SGTC_2860 9025725 38.96 µM 2.22293133935739 0.0453340408057742 no 275 0.0131102150784327 127 40546248
SGTC_1485 3909-9022 254 µM 2.22215702655854 0.045399978842808 no 276 0.0131363477461261 138 714516
SGTC_1841 st054148 70 µM 2.22177594493742 0.0454324588638207 no 277 0.0131492255801354 144 675442
SGTC_1873 rapamycin 2 nM 2.21669349627627 0.0458674309044391 no 278 0.0133220217624529 237 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2344 7990960 76.95 µM 2.21029711954844 0.0464196021452313 no 279 0.0135422742035752 165 140813
SGTC_3184 9108758 49.47 µM 2.20246993195955 0.0471025351972226 no 280 0.0138160653975209 105 902885
SGTC_34 0469-0683 81.75 µM 2.19752102410361 0.0475384750793089 no 281 0.0139916283232515 161 3690923
SGTC_2396 5342950 42.78 µM 2.19361372208016 0.0478849401916308 no 282 0.014131595542568 226 1886677
SGTC_1075 aripiprazole 15.2 µM 2.19211326360963 0.048018523619241 no 283 0.0141856646319809 210 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1713 st033146 12.748 µM 2.18863068110621 0.0483297219638158 no 284 0.0143118469833191 189 674619
SGTC_389 tpck 16.7 µM 2.18843817667846 0.0483469708121631 no 285 0.0143188499869991 176 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2188 6126565 140.678 µM 2.18269083692348 0.0488642177947488 no 286 0.0145292925873432 125 874518
SGTC_107 0358-0022 2.6945 µM 2.17551035981738 0.0495166467871351 no 287 0.0147959463158886 106 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1318 1280-3875 124 µM 2.16210189990208 0.0507535590697869 no 288 0.0153051613140394 217 373245
SGTC_1389 3405-0187 19 µM 2.16054425324145 0.0508988312195175 no 289 0.0153652808308423 168 799890
SGTC_568 1193-0097 7.48 µM 2.15737119752574 0.0511957865796093 no 290 0.0154883767797155 331 3646150
SGTC_2455 5377712 9.75 µM 2.15644941100255 0.0512823113214068 no 291 0.0155242949831292 169 2243908
SGTC_1797 st048695 56.8 µM 2.15560655521161 0.0513615289047565 no 292 0.0155572001311288 205 592262 YIL048W NEO1
SGTC_2561 acetosyringone 100 µM 2.15164052771566 0.0517355918008426 no 293 0.0157128387717513 222 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2598 perillyl alcohol 100 µM 2.14847570431929 0.0520356385018136 no 294 0.015837992218904 214 10819 An apoptosis inducer.
SGTC_753 1322-0200 289 µM 2.14825049921711 0.0520570420495354 no 295 0.015846930479608 163 5403907
SGTC_834 0312-0008 75.7 µM 2.14489276061202 0.052376992560422 no 296 0.0159807110967241 226 6385573 YIL048W NEO1
SGTC_2938 9059746 27.26 µM 2.14477738265534 0.0523880143212194 no 297 0.0159853251930929 194 6471769
SGTC_3246 9135460 32.98 µM 2.14339105045045 0.0525205911234197 no 298 0.0160408555603062 108 41446951
SGTC_788 1182-0090 188 µM 2.14252563794581 0.0526034865955192 no 299 0.0160756039288888 285 5715185
SGTC_3267 9137951 49.47 µM 2.12588089782491 0.0542181326499866 no 300 0.0167565889046855 106 16643986
SGTC_713 1488-1073 324 µM 2.11827059447084 0.054969328194422 no 301 0.0170760787521861 136 3312542
SGTC_2449 5812982 45.77 µM 2.11598673360201 0.0551963601830024 no 302 0.0171729679453392 138 776185
SGTC_2514 salinomycin 42.74 µM 2.11527184694782 0.0552675769980346 no 303 0.0172033922534681 256 23682228 A polyether potassium ionophore.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.11487951863396 0.0553066914694849 no 304 0.0172201086144898 225 676296 Flavone; oxidizing agent.
SGTC_505 gw-5074 63.9 µM 2.11483763993711 0.0553108679959952 no 305 0.0172218938053444 209 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2250 alverine citrate 130 µM 2.10816983353284 0.0559790255042485 no 306 0.0175081508223911 409 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2424 5537928 59.2 µM 2.10789035858978 0.0560071691182115 no 307 0.0175202371960539 235 5382802
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.10342914882052 0.0564579332978221 no 308 0.0177141363254138 254 688664
SGTC_3022 9087993 49.47 µM 2.10217903002006 0.0565847578038843 no 309 0.0177687980120295 139 17173644
SGTC_2463 5473429 200 µM 2.10056730537967 0.0567485983437605 no 310 0.0178394832908881 175 5399405
SGTC_1259 0671-0132 43 µM 2.09824240444429 0.0569855951297919 no 311 0.0179418687365684 202 X1259
SGTC_823 0417-1665 178 µM 2.09541378923269 0.0572749898228249 no 312 0.0180671123955368 205 3429856
SGTC_1276 0871-0068 94.2 µM 2.08960769291883 0.0578726321096264 no 313 0.0183265274600839 164 3414906
SGTC_1773 st048542 73.5835 µM 2.08959897303974 0.0578735333505946 no 314 0.0183269194362642 232 3237138
SGTC_2951 9072950 58.06 µM 2.08746849529726 0.0580940591946122 no 315 0.0184229030079968 218 16488155
SGTC_1409 3909-8004 61.9 µM 2.08711317503011 0.0581309025726443 no 316 0.0184389526976467 233 2119279
SGTC_1027 k015-0025 8.67 µM 2.08642427908957 0.0582023869202353 no 317 0.0184701038084035 196 3598955
SGTC_1304 1165-0502 251 µM 2.07315420581216 0.059592897867716 no 318 0.0190789653386878 256 767425
SGTC_2734 clemastine 41.6 µM 2.06754629266987 0.0601882950879405 no 319 0.019341353420533 72 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_974 1326-0144 138 µM 2.06257635156641 0.0607198415049181 no 320 0.0195764482501609 242 5411856
SGTC_2864 9034755 47.6 µM 2.05871128270996 0.0611357515801651 no 321 0.0197609523700229 201 4930451
SGTC_80 0159-0065 512.242 µM 2.05703669094066 0.0613166399276566 no 322 0.0198413483252398 106 1548079
SGTC_785 1270-0111 65.3 µM 2.05636729845533 0.0613890641567048 no 323 0.0198735629502515 236 6741994
SGTC_214 4373-3496 70 µM 2.05389786311691 0.0616568202696572 no 324 0.0199927891013666 325 3779166
SGTC_1857 st056007 79.3 µM 2.05046079487205 0.0620310117210838 no 325 0.0201597429103038 149 619834
SGTC_600 1495-0418 41.6 µM 2.03944711156592 0.0632420088716588 no 326 0.0207027122906646 191 5377768
SGTC_1981 st071826 47 µM 2.03916511017155 0.0632732560020292 no 327 0.020716775875008 164 11838600
SGTC_1245 0418-0076 17.2 µM 2.03382976703525 0.0638667057914954 no 328 0.0209843810778469 228 6790114
SGTC_1872 amphotericin b 148 nM 2.03161776507346 0.0641140123744673 no 329 0.0210961834077369 199 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2173 5763948 167 µM 2.02254157214456 0.0651365515281012 no 330 0.0215602166764458 197 2867177
SGTC_31 0508-1974 57.237 µM 2.0112246447507 0.0664292100564102 no 331 0.0221508668884506 195 6810525
SGTC_630 4356-0227 183 µM 2.00978990779238 0.0665944995063934 no 332 0.0222267146945241 181 779312
SGTC_640 3381-0960 37.1 µM 2.0052212201853 0.0671229582430855 no 333 0.0224697012402179 207 1745025
SGTC_763 3453-1109 128 µM 2.00408035351927 0.0672554266179157 no 334 0.0225307267962509 216 1560353
SGTC_2331 7980721 200 µM 2.00094652137359 0.0676203424650913 no 335 0.0226990766921584 241 2981221
SGTC_2875 9039966 71.43 µM 2.00001269431964 0.0677293763048802 no 336 0.0227494465782928 153 6463691
SGTC_555 4296-0685 37 µM 1.99265750508078 0.0685929228812764 no 337 0.0231494818181778 212 2908540 YHR072W ERG7
SGTC_2485 5633444 17.78 µM 1.99022359193694 0.0688805423300318 no 338 0.0232831552912535 259 5724239
SGTC_3019 9081971 49.47 µM 1.98766270442594 0.0691841693704594 no 339 0.0234245031608985 209 16451803
SGTC_900 1112-0045 141 µM 1.98607147286183 0.0693733497004867 no 340 0.0235126941618536 162 56211 YIL048W NEO1
SGTC_3292 9120825 59.784 µM 1.98241392713218 0.0698097028856603 no 341 0.0237164660542217 213 24824900
SGTC_2371 9071574 200 µM 1.98155916027274 0.0699119823141034 no 342 0.023764300929365 174 45596039
SGTC_1038 k292-0204 154 µM 1.97460450051089 0.0707484515579504 no 343 0.0241565239688753 212 4454212
SGTC_1498 4478-3555 97.6 µM 1.97360690840452 0.070869064628442 no 344 0.0242132287994516 146 3437919
SGTC_2318 6029776 164 µM 1.96770136453979 0.0715863075252983 no 345 0.0245512043715232 249 818325
SGTC_679 0422-0091 41.4 µM 1.96335619049266 0.0721175865928841 no 346 0.0248024002747053 274 627384 YHR062C RPP1
SGTC_641 4092-0595 30 µM 1.95976566669664 0.0725588717999647 no 347 0.0250115929530464 231 786260
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.95962371568446 0.0725763603742449 no 348 0.0250198936695871 197 229346 A bile salt which induces apoptosis.
SGTC_605 1315-0399 119 µM 1.95637750977409 0.0729771794496988 no 349 0.0252103497640008 256 24020461
SGTC_3112 9123419 49.47 µM 1.95127337740992 0.0736108258325324 no 350 0.0255122671281317 238 17015854
SGTC_3156 9099931 49.47 µM 1.94232410808822 0.0747319635856427 no 351 0.0260489381436523 220 18111053
SGTC_2773 thioridazine 9.09 µM 1.94214475871344 0.0747545643818036 no 352 0.0260597891724038 206 5452 An antipsychotic.
SGTC_19 0279-0214 38.434 µM 1.94166880801612 0.0748145668181067 no 353 0.0260886035587154 334 3566274 YBR002C RER2
SGTC_2327 6189656 200 µM 1.93459180084093 0.0757110958985897 no 354 0.0265202034848729 208 5349088
SGTC_1545 lovastatin 49.4 µM 1.92759933964371 0.0766049293542664 no 355 0.0269524905421057 273 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_456 gingerol 170 µM 1.92631048357811 0.0767705539191802 no 356 0.027032808591642 237 442793 A herb.
SGTC_759 3486-0358 89.3 µM 1.91768236338124 0.0778863311232373 no 357 0.0275756496874417 259 875103
SGTC_2367 9070478 135.38 µM 1.91650910043154 0.0780390016379703 no 358 0.0276501629842173 260 572802
SGTC_2467 5474540 200 µM 1.9138255684557 0.078389048889483 no 359 0.0278212236758071 265 5413519
SGTC_3011 9081274 71.4286 µM 1.91232042912481 0.078585903814561 no 360 0.0279175535335576 275 6625322
SGTC_1187 1391-0724 117 µM 1.9118148262068 0.0786521148707283 no 361 0.0279499747099902 263 6997986
SGTC_1488 4013-0813 75.9 µM 1.91163522857318 0.0786756441903314 no 362 0.02796149873699 189 2910057
SGTC_1833 st055984 71 µM 1.9072100592157 0.0792570777295449 no 363 0.0282466956996755 230 676288
SGTC_923 1900-2434 73.3 µM 1.90682748411482 0.0793074975604626 no 364 0.0282714655242502 264 5910570
SGTC_1394 3474-0001 65.7 µM 1.90649360962137 0.0793515189434271 no 365 0.0282930969988783 220 5017666 YIL048W NEO1
SGTC_2350 9023895 38.85 µM 1.90533279853592 0.0795047159422784 no 366 0.0283684122984118 263 2997209
SGTC_1899 st063254 59.6 µM 1.90104296927277 0.0800728045625589 no 367 0.0286481923121036 209 3093813
SGTC_3182 9108849 49.47 µM 1.88960893870128 0.0816019634580974 no 368 0.029405140401742 290 17133045
SGTC_507 nimesulide 162 µM 1.88702527579996 0.0819505262818478 no 369 0.0295784630422982 258 4495 A COX2 inhibitor.
SGTC_2040 5100729 123 µM 1.881607058862 0.0826851414144849 no 370 0.0299446935507272 279 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2725 haloperidol 53.21 µM 1.87860150929627 0.0830947724500938 no 371 0.0301494624608036 281 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2271 7849410 118.62 µM 1.87702314047092 0.0833105010529199 no 372 0.0302574611801334 248 972430
SGTC_385 1494-0393 12.4 µM 1.87482803729422 0.0836112233806517 no 373 0.0304081923464802 263 3090647
SGTC_2022 5136654 200 µM 1.86614205833593 0.0848091774616544 no 374 0.0310107465075665 269 1713771
SGTC_136 0097-0015 404.482 µM 1.86599542302809 0.0848295110210957 no 375 0.0310210029270618 278 4861337
SGTC_2373 9071805 200 µM 1.86561599864749 0.0848821418371479 no 376 0.031047554827448 223 10149009
SGTC_2622 2-methoxyxanthone 59.94 µM 1.86332754650189 0.0852000974337842 no 377 0.0312080984120453 244 71034 A hepatoprotective.
SGTC_1520 flindersine 88 µM 1.86035526951672 0.08561439426173 no 378 0.0314176393776546 282 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_359 0081-0058 15.9 µM 1.85955318745464 0.085726452117781 no 379 0.0314743838127246 280 3494159
SGTC_2431 5490079 200 µM 1.85544768787241 0.0863017460358697 no 380 0.0317661614409781 268 5722345
SGTC_1303 1160-0052 261 µM 1.85315808792432 0.0866238337993522 no 381 0.031929851504876 260 3562476
SGTC_1016 4226-1401 38 µM 1.85118385295557 0.0869022784772536 no 382 0.0320715539573901 282 2901613
SGTC_1372 2752-0194 270 µM 1.84501232275581 0.0877770187732972 no 383 0.0325178730370785 246 823334
SGTC_808 0711-0032 135 µM 1.84474403970474 0.0878151930995079 no 384 0.0325373906309007 239 4252555
SGTC_3322 9139058 2.11 µM 1.84354487897956 0.0879859745455694 no 385 0.0326247477393839 270 4908926 YPR165W RHO1
SGTC_301 4119-0100 24.5 µM 1.8346525626187 0.0892601304644336 no 386 0.0332785926057183 333 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3056 9094900 49.47 µM 1.83426952813112 0.0893153212435692 no 387 0.0333069975393288 285 25236784
SGTC_2482 5981709 142.65 µM 1.83349720819351 0.0894266806876698 no 388 0.0333643316824731 317 877755
SGTC_1109 tnp00067 928.257 nM 1.832158359369 0.0896199715685083 no 389 0.0334639153567261 244 676295
SGTC_2012 4023501 200 µM 1.82719198094652 0.0903396860443874 no 390 0.0338354545769666 264 3477460
SGTC_3072 9116419 49.47 µM 1.82613903239953 0.0904928265455828 no 391 0.033914661030997 247 17170162
SGTC_361 000s-0510 1.45 µM 1.82242913282692 0.0910339290390657 no 392 0.0341949487604311 311 660
SGTC_2705 st078069 42.8 µM 1.82155811658129 0.0911613171255368 no 393 0.0342610304557396 234 1530061
SGTC_1429 4049-0205 9.46 µM 1.81755285415773 0.0917487976325687 no 394 0.0345662515186636 276 22774478
SGTC_1811 st050069 61.5 µM 1.81734968382202 0.0917786726503876 no 395 0.0345817934502132 205 3877702
SGTC_2268 7933382 153.85 µM 1.81705699012648 0.0918217242260453 no 396 0.0346041937455965 342 935025 YOR257W CDC31
SGTC_674 0498-0004 451 µM 1.81416755194384 0.0922475273675146 no 397 0.034825967040957 296 4231473
SGTC_1212 0520-0165 585 µM 1.81252559031987 0.0924901459815507 no 398 0.0349525117590668 296 5403258
SGTC_1386 3228-0095 33.8 µM 1.80993658581057 0.0928736596064983 no 399 0.0351528108688027 257 870181
SGTC_1534 6-azauridine 81.6 µM 1.80987270844923 0.092883136708544 no 400 0.0351577646396177 331 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2923 7992654 58.14 µM 1.80782469753881 0.0931873669128313 no 401 0.0353168943028929 286 2985126
SGTC_467 ro 31-8220 72.8 µM 1.80528470791515 0.0935657022740179 no 402 0.0355150706751463 347 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1649 st011737 51.3 µM 1.80075388225206 0.09424339002633 no 403 0.0358708403605267 268 1761035
SGTC_1687 st020778 55.3625 µM 1.79969449319796 0.0944023666376632 no 404 0.0359544455560392 468 4259299
SGTC_3132 9126706 49.47 µM 1.79858228667897 0.0945694819656127 no 405 0.0360423907025563 277 850858
SGTC_1345 1488-0192 31.4 µM 1.79554703249917 0.0950266556258446 no 406 0.0362832931518268 285 658348
SGTC_651 3253-0966 34.4 µM 1.79540845911229 0.0950475665080737 no 407 0.036294322848748 302 781462
SGTC_1478 0453-0656 35.7 µM 1.78989368270945 0.0958825062425909 no 408 0.0367355023073369 283 5258496
SGTC_1321 1326-2144 215 µM 1.78169597611059 0.0971335936172329 no 409 0.0373994117250421 259 3513030
SGTC_1419 3993-2473 62.6 µM 1.77864284201091 0.0976025944327916 no 410 0.0376491677802807 273 704026
SGTC_3265 9137266 49.47 µM 1.76624984869936 0.099523371243749 no 411 0.0386769706680493 231 17224265
SGTC_3174 9107204 49.47 µM 1.76592660945203 0.0995738368111424 no 412 0.038704081149227 303 3938802
SGTC_2131 toluylene red 5.2905 µM 1.76535066249882 0.0996638025847024 no 413 0.0387524249095335 319 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_27 0485-0001 32.618 µM 1.76480405696314 0.0997492400000566 no 414 0.0387983512974099 193 2054479
SGTC_2533 agelasine 13.65 µM 1.76438900434682 0.0998141507106198 no 415 0.0388332540718352 340 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_768 0384-0033 77.3 µM 1.7643281013456 0.0998236780190589 no 416 0.0388383777028498 370 3965305 YMR134W ERG29
SGTC_1463 k081-0032 34.1 µM 1.76241841223143 0.100122755646815 no 417 0.0389993150122105 204 977755
SGTC_990 3985-0011 41.3 µM 1.76112133956738 0.100326263748028 no 418 0.0391089339636242 258 5399565 YGL099W LSG1
SGTC_1854 st056233 32.9 µM 1.76080073219047 0.100376612902776 no 419 0.0391360679442607 274 5393174
SGTC_302 1094-0063 18.9 µM 1.76014557134457 0.100479558684813 no 420 0.0391915638594052 234 5440289
SGTC_2594 a-mangostin 100 µM 1.75809649283794 0.100802028710239 no 421 0.0393655462155421 338 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_868 0527-0199 213 µM 1.75562786446358 0.101191526091526 no 422 0.0395759855892158 315 2849450
SGTC_491 tetrandrine 80.3 µM 1.75416451263819 0.101422929208264 no 423 0.0397011610188305 230 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1557 sumaresinolic acid 42.3 µM 1.75222436813052 0.10173032260002 no 424 0.0398676175426141 283 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_43 0570-0105 72.5 µM 1.75068683444776 0.101974408296804 no 425 0.0399999342325996 458 1114046 YDL195W SEC31
SGTC_1710 st031758 61.5 µM 1.75006064485313 0.102073938836005 no 426 0.0400539248661286 255 5394341
SGTC_2180 6301957 200 µM 1.74949813801175 0.102163407483614 no 427 0.0401024751883246 240 845462
SGTC_1824 st053723 68.6 µM 1.74816978165816 0.102374913530995 no 428 0.0402173162547258 317 675225
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.74310509584364 0.103184253859375 no 429 0.0406576293284814 386 688788
SGTC_741 4582-0002 126 µM 1.74274451739366 0.10324205122049 no 430 0.04068912586489 304 2912688
SGTC_3356 9151811 4.48 µM 1.74178711265869 0.103395628329563 no 431 0.0407728512888202 305 1859254 YPR165W RHO1
SGTC_96 0929-0093 37.281 µM 1.73773183291415 0.104047973869602 no 432 0.0411290384390899 285 6991579
SGTC_2924 9010168 62.78 µM 1.73548360813863 0.104410913941479 no 433 0.0413275912071712 328 2993929
SGTC_1114 scopoletin 1.73284 µM 1.73515873582976 0.104463435165333 no 434 0.0413563465589864 274 5280460 A coumarin with genotoxic properties.
SGTC_1867 st057372 64 µM 1.73366475925393 0.104705208725779 no 435 0.0414887914027512 294 688837
SGTC_109 0132-0036 33.701 µM 1.73337933697773 0.104751445320443 no 436 0.0415141338787836 194 67274 A color developer.
SGTC_3289 9119912 71.43 µM 1.73057314459473 0.10520681813768 no 437 0.0417639624814038 316 17014829
SGTC_1684 st024538 14.6195 µM 1.73008762314406 0.105285750914291 no 438 0.0418073106015238 312 6732859
SGTC_2516 gossypol 71.55 µM 1.72826909416029 0.105581775763497 no 439 0.0419699956389132 325 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2619 obliquin 87.91 µM 1.7233247457043 0.106389671265947 no 440 0.0424149076144376 459 6708593 A bioactive alkalod. YER133W GLC7
SGTC_965 1291-5240 308 µM 1.72241615385738 0.106538617384082 no 441 0.0424970797467147 327 2834598
SGTC_2009 4012297 12.05 µM 1.72203956382599 0.106600396167067 no 442 0.0425311758882139 336 45595307
SGTC_424 splitomicin 100 mM 1.72201527853534 0.106604381004019 no 443 0.0425333754168726 312 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1172 0370-0043 85 µM 1.72158470005333 0.106675050062679 no 444 0.0425723883610086 276 376585
SGTC_877 0771-0151 33.1 µM 1.7201506128693 0.106910664664454 no 445 0.0427025338155994 326 6166523
SGTC_3185 9108267 49.47 µM 1.71985137693187 0.106959875199562 no 446 0.0427297304196246 339 4910486
SGTC_1238 0333-0287 48.8 µM 1.71970690043239 0.106983640780465 no 447 0.0427428664410863 313 7226
SGTC_1689 st020265 53.493 µM 1.71656402565459 0.107501569201336 no 448 0.0430294301066605 299 5758320 YPR016C TIF6
SGTC_3152 9099253 49.47 µM 1.71507658623846 0.10774732001404 no 449 0.0431655932013373 466 25236131
SGTC_1614 st002383 48.6 µM 1.71461669942348 0.107823383141743 no 450 0.0432077624978095 314 1947235
SGTC_525 k781-2675 26.7 µM 1.7121207130291 0.108236882242258 no 451 0.0434372124852305 362 3651118 YDL195W SEC31
SGTC_237 nikkomycin 200 µM 1.70931816529092 0.108702526838383 no 452 0.0436960151311735 329 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_528 3492-0019 172 µM 1.70915557186047 0.108729585958879 no 453 0.0437110680050109 580 2869262
SGTC_192 3455-0609 60.9 µM 1.70694134016989 0.109098565013613 no 454 0.0439164779779787 299 3769639
SGTC_2601 securinine 100 µM 1.70664830534521 0.109147463613359 no 455 0.0439437204887065 316 442872 A GABA receptor antagonist.
SGTC_2217 6934799 96.0675 µM 1.70527778841063 0.109376370286909 no 456 0.0440713140525847 278 675606
SGTC_941 3237-0776 460 µM 1.70267317043639 0.109812349149081 no 457 0.0443146242301105 291 760008
SGTC_236 1509-0011 5.31 µM 1.69767872869698 0.110651839317055 no 458 0.0447842073034421 667 3107280
SGTC_2122 5258151 111.688 µM 1.69342650951094 0.111370189926298 no 459 0.0451871562314116 339 2173356
SGTC_3078 9116413 49.47 µM 1.68865719444595 0.112179860909196 no 460 0.045642571617088 309 17177322
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.68626540867155 0.1125874868518 no 461 0.0458723452539888 336 66535 A nucleotide analog.
SGTC_1852 st056254 31.4 µM 1.68546022183796 0.11272495051563 no 462 0.0459499065967319 308 442583
SGTC_1008 4106-0037 6 µM 1.68273155733434 0.113191686591896 no 463 0.0462135348896011 295 2905394
SGTC_1287 0971-0001 34.6 µM 1.68251516529016 0.113228759213453 no 464 0.0462344933533888 381 4665869
SGTC_3338 9144300 39.5675 µM 1.67821774602049 0.113966794651393 no 465 0.0466522993112427 330 4901274
SGTC_3223 9129970 49.47 µM 1.67801409737824 0.114001853972713 no 466 0.0466721734855144 349 17248386
SGTC_1900 st060200 72.8 µM 1.67151878685928 0.115124093464162 no 467 0.0473096255355275 338 688945
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.66955093109988 0.115465638667064 no 468 0.0475041228158673 316 97141
SGTC_2966 9084041 48.03 µM 1.6688792261785 0.115582385859872 no 469 0.047570658682492 335 17741380
SGTC_262 fenpropimorph 62.5 µM 1.66779372749489 0.115771230637887 no 470 0.0476783407462087 306 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_966 1300-0360 30.2 µM 1.66602224668601 0.116079886502421 no 471 0.0478544917620408 341 70588
SGTC_2187 6125751 200 µM 1.66508571470884 0.116243299982308 no 472 0.0479478281616602 343 874498
SGTC_1197 1601-0112 267 µM 1.66345442907008 0.116528329235973 no 473 0.0481107528314222 367 7350313
SGTC_2863 9028737 58.44 µM 1.65439959837392 0.118119462911145 no 474 0.0490231740141148 268 6460917
SGTC_1812 st052057 4.327 µM 1.65168741980145 0.118599029213951 no 475 0.0492991442636988 351 3645418
SGTC_2135 5326629 150.42 µM 1.6516068805478 0.118613291135654 no 476 0.0493073582389415 331 5020077
SGTC_3035 9091303 49.47 µM 1.64668015105419 0.119488023739234 no 477 0.0498119030690534 297 25237002
SGTC_2093 5331342 194.4 µM 1.64601550328064 0.119606378341505 no 478 0.0498802836001335 353 33839
SGTC_564 3555-0129 330 µM 1.64380208635035 0.120001120195613 no 479 0.0501085451377057 253 563260
SGTC_1363 1636-0063 10.4 µM 1.64330869468597 0.12008923692154 no 480 0.0501595401399595 369 6072185
SGTC_1763 st044482 94.5 µM 1.64301911627148 0.12014097508092 no 481 0.0501894890755606 364 88505
SGTC_1424 4048-1941 275 µM 1.64273622368272 0.120191533868319 no 482 0.0502187603088218 369 X1424
SGTC_449 xestospongin c 11.1929 µM 1.64127392655458 0.120453115796913 no 483 0.0503702829617792 376 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_336 4111-0029 111 µM 1.64033106896649 0.120621990628992 no 484 0.050468174524415 294 3131175
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.63860849044913 0.120930951282199 no 485 0.0506474114758366 349 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_382 3229-0966 23.2 µM 1.63851527776186 0.120947685721511 no 486 0.0506571248409639 364 5722370
SGTC_1760 st045453 10.4495 µM 1.63565197230079 0.121462527864568 no 487 0.0509562232466025 450 3323419 YIL048W NEO1
SGTC_3101 9120531 49.47 µM 1.63334495680777 0.121878464496751 no 488 0.0511982332825087 379 24824904
SGTC_800 3448-7362 155 µM 1.63210372535581 0.122102662219056 no 489 0.05132881855716 643 15991913
SGTC_1607 st000305 50.6 µM 1.63033496303886 0.122422645445343 no 490 0.051515360989764 359 5457690
SGTC_2600 tangeritin 87.95 µM 1.62615906929692 0.12318043139779 no 491 0.0519579104257708 341 68077 A bioactive flavone.
SGTC_3026 9090633 49.47 µM 1.62576273745947 0.123252522888628 no 492 0.0520000690335603 345 25236842
SGTC_1617 st002906 78 µM 1.62331300912594 0.123698776759877 no 493 0.0522612549922145 376 5150859
SGTC_2317 5986382 200 µM 1.6222547750424 0.123891899064462 no 494 0.0523744038867058 333 877883
SGTC_2729 fluphenazine 10.66 µM 1.62044337786935 0.124222959357394 no 495 0.0525685340775682 386 3372 An atypical antipsychotic.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.61926142326329 0.124439312823416 no 496 0.0526955135519546 364 94937 An inhibitor of serotonin biosynthesis.
SGTC_1667 st014849 34.6 µM 1.61867484141554 0.124546782751633 no 497 0.0527586213784136 344 5348460
SGTC_268 camptothecin 39.6153 µM 1.61865900432633 0.124549685225284 no 498 0.052760326053915 484 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2842 9000675 19.48 µM 1.61803467641573 0.124664143885476 no 499 0.0528275624005138 354 2989072
SGTC_3092 9117248 49.47 µM 1.61676045925351 0.124897975485498 no 500 0.0529649988202856 298 17141857
SGTC_797 k781-0471 270 µM 1.61551457017233 0.12512690471491 no 501 0.0530996538285543 356 23738129
SGTC_485 niflumic acid 177 µM 1.61454688711239 0.125304916310017 no 502 0.0532044276576746 323 4488 A COX2 inhibitor.
SGTC_129 0088-0017 176.636 µM 1.61344348356452 0.125508110218357 no 503 0.0533240962432687 387 182446
SGTC_232 clozapine 119 µM 1.61199238301956 0.125775683101415 no 504 0.0534817986231599 370 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2273 7815444 169.05 µM 1.60720108666599 0.12666198982403 no 505 0.0540051318757036 352 2824616
SGTC_105 0111-0055 734.78 µM 1.60697470162921 0.126703974472232 no 506 0.054029958905545 291 5179370
SGTC_127 0180-0333 59.125 µM 1.60630853428248 0.126827575960549 no 507 0.0541030680725198 470 771601
SGTC_1947 st076332 61.6 µM 1.60308245284614 0.127427334486818 no 508 0.0544582257448917 295 24208416
SGTC_1548 st061468 90.8 µM 1.60216837847893 0.127597627440478 no 509 0.0545591902825252 339 390799
SGTC_904 1141-0088 396 µM 1.60211232042726 0.127608076257406 no 510 0.0545653870167047 360 1378119
SGTC_3043 9092303 49.47 µM 1.60135653819545 0.127749006695099 no 511 0.0546489865714913 350 25236084
SGTC_2213 7173844 200 µM 1.59743464153395 0.128482058365787 no 512 0.0550844278703075 356 892728
SGTC_764 1951-2361 146 µM 1.59678030847895 0.128604645056371 no 513 0.0551573434136849 386 5438930
SGTC_1392 3455-1037 33.9 µM 1.59593711597712 0.128762733467406 no 514 0.0552514168983706 358 981132
SGTC_1742 st038235 28.8875 µM 1.59254880963241 0.12939935913286 no 515 0.0556307225558685 426 564103 YBR002C RER2
SGTC_2101 5377231 179.231 µM 1.58990255518365 0.129898075925164 no 516 0.0559283858110019 326 2844213
SGTC_3290 9121031 71.43 µM 1.58643379816222 0.130553815841334 no 517 0.0563204692818545 331 17014854
SGTC_2683 piperine 63.03 µM 1.58488872642366 0.130846634540567 no 518 0.0564958091894281 325 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_710 3448-4187 58 µM 1.58245087428245 0.131309573589864 no 519 0.0567733393135187 478 3946412
SGTC_1750 st081859 2.357 µM 1.57669564236281 0.132406953623969 no 520 0.0574327867784688 604 5291695
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.57623267915746 0.132495503077498 no 521 0.057486094939572 430 6708784 An antioxidant flavonoid
SGTC_1475 4092-1048 11.7 µM 1.57386349326517 0.132949288134552 no 522 0.05775950569032 413 2881759
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.57331735843549 0.133054044342896 no 523 0.0578226759715618 448 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.57113046974941 0.133474088995433 no 524 0.0580761731933256 325 6857784
SGTC_458 nppb 133 µM 1.56943692881402 0.133800000327705 no 525 0.0582730824581283 333 4549 A chloride channel blocker.
SGTC_801 0866-0028 10.1 µM 1.56815355496485 0.134047341623242 no 526 0.0584226502908453 416 6849771
SGTC_3192 9110362 49.47 µM 1.56644612444391 0.134376896990846 no 527 0.0586221059895497 384 16649480
SGTC_2895 9054447 58.44 µM 1.56356784659417 0.134933698987421 no 528 0.058959545396803 338 2697450
SGTC_2215 7188065 200 µM 1.55984210156463 0.13565679046042 no 529 0.0593985997447143 304 940217
SGTC_2493 resveratrol 26.09 µM 1.55868375969917 0.135882141039058 no 530 0.0595356237235565 321 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2178 5812956 200 µM 1.55840389115918 0.135936626722493 no 531 0.0595687674031112 361 5403383
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.55793867334901 0.136027229876952 no 532 0.0596238932287998 387 6708760
SGTC_146 3448-8650 53.125 µM 1.55731265020197 0.136149215786506 no 533 0.0596981367105157 562 2891488 YIL048W NEO1
SGTC_980 1473-0395 201 µM 1.55432153585956 0.136733093039796 no 534 0.0600538695042389 337 768876
SGTC_2674 ligustilide 100 µM 1.55406454935635 0.136783337550744 no 535 0.0600845101380584 351 5319022 A signalling regulator.
SGTC_2857 9024691 58.44 µM 1.55213963927611 0.1371600861259 no 536 0.0603144075469668 387 16478292
SGTC_613 3914-0030 117 µM 1.53657446663718 0.140232580391735 no 537 0.0621987746119806 153 1145395
SGTC_2142 5622915 118.518 µM 1.53464150302904 0.140617376588714 no 538 0.0624359560451575 360 5322196
SGTC_1720 st037298 9.481 µM 1.52181947123028 0.14318800233278 no 539 0.0640271606296428 393 597396
SGTC_2164 5685496 200 µM 1.5190466083626 0.143748068279145 no 540 0.0643753822664654 410 759046
SGTC_1449 4112-4002 201 µM 1.51836342173973 0.143886285731659 no 541 0.0644614037516688 397 2059539
SGTC_2698 st077697 67.5 µM 1.51776052084656 0.144008334790193 no 542 0.0645373904451494 393 3154499
SGTC_1369 1866-0067 208 µM 1.517723485279 0.144015834410993 no 543 0.0645420604952937 472 3531355
SGTC_3249 9135183 49.47 µM 1.51708244627752 0.1441456851319 no 544 0.0646229347800226 418 4902779
SGTC_1917 st066507 28.5 µM 1.51546838501998 0.144472983584212 no 545 0.0648269153699162 474 3156428
SGTC_466 geldanamycin 89.2 µM 1.51235087651516 0.145106566945359 no 546 0.0652223123252693 290 5288382 HSP90 inhibitor.
SGTC_3273 9137859 49.47 µM 1.51214639171729 0.145148190437898 no 547 0.065248312600871 353 2377234
SGTC_2737 bleomycin 30.5 nM 1.51141982532604 0.145296150191338 no 548 0.0653407606887959 474 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2636 apigenin dimethyl ether 100 µM 1.5098553907769 0.145615079825429 no 549 0.0655401637746969 470 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2435 5706476 10.6 µM 1.50858322538854 0.145874773477949 no 550 0.0657026618001685 446 5725375
SGTC_1839 st053978 48 µM 1.50437216931185 0.14673661723558 no 551 0.066242783034974 412 3788398
SGTC_2809 7964133 12.99 µM 1.50386732775599 0.146840168055246 no 552 0.066307765534821 454 1253665
SGTC_3220 9131269 49.47 µM 1.49926335940525 0.147786774925919 no 553 0.0669026619093531 374 17722206
SGTC_1281 0884-0031 11.8 µM 1.49584317282386 0.148492627849369 no 554 0.0673472639380902 461 1548255
SGTC_1703 st026983 48.3 µM 1.49432610788303 0.148806437987513 no 555 0.0675452022312656 426 1104023
SGTC_1278 0874-0585 172 µM 1.49417587306682 0.148837538680338 no 556 0.0675648284815066 413 766306
SGTC_758 0868-0029 16 µM 1.49259912506467 0.149164209425354 no 557 0.0677710762615074 423 762687
SGTC_755 1995-0008 37.3 µM 1.49044411179954 0.149611459097733 no 558 0.068053750601419 414 689533
SGTC_26 0302-0163 425.158 µM 1.48955872660475 0.149795470285558 no 559 0.0681701505613087 395 3100915
SGTC_3138 9097216 49.47 µM 1.48932091439671 0.149844920930966 no 560 0.068201441460687 411 25237486
SGTC_93 0109-0045 59.227 µM 1.48790989150307 0.150138552822221 no 561 0.0683873293665805 537 88733
SGTC_2709 st078560 56 µM 1.48648982712609 0.150434453232327 no 562 0.0685748028368143 409 17250903
SGTC_3193 9111931 49.47 µM 1.48582448139707 0.150573225642575 no 563 0.0686627764346025 430 17087244
SGTC_1879 gemcitabine 100 µM 1.48372027615685 0.151012664753111 no 564 0.0689415724250615 419 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3010 9080089 71.4286 µM 1.48363247405032 0.151031019745691 no 565 0.0689532246735757 411 17027233
SGTC_3288 9119690 36.221 µM 1.48307679404015 0.151147218841626 no 566 0.0690270043719787 379 17595618 YKL019W RAM2
SGTC_2643 anethole 100 µM 1.47841645034826 0.15212409121823 no 567 0.0696481724761819 450 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1844 rapamycin 4 nM 1.47498989997706 0.152845012224005 no 568 0.0701076294139642 587 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_35 0133-0054 64.071 µM 1.47451775775536 0.152944524780021 no 569 0.0701711200421381 419 99677
SGTC_1999 st074831 12.5 µM 1.47155352821165 0.153570271293449 no 570 0.070570741330545 459 17112523
SGTC_1194 1488-0194 225 µM 1.46713623321958 0.1545059001122 no 571 0.0711694996329176 482 1391452
SGTC_108 0509-0257 621.132 µM 1.46646374873127 0.154648669077641 no 572 0.071260995099658 488 536624
SGTC_1158 4092-0494 91.8 µM 1.46536193940285 0.154882772401892 no 573 0.071411097877225 451 1148199
SGTC_2459 5811157 9.22 µM 1.46384718765182 0.155204996228538 no 574 0.0716178530093241 416 2870684 YBR192W RIM2
SGTC_948 3448-0295 75.3 µM 1.45776559163015 0.15650314868538 no 575 0.0724525827464684 502 678569
SGTC_191 3914-0123 66.505 µM 1.45710795056954 0.156643953160047 no 576 0.072543292038339 305 3144412
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.45477166260694 0.157144839055998 no 577 0.0728662428317593 365 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3252 9135871 49.47 µM 1.45380287202744 0.157352850447179 no 578 0.0730004835040412 440 17682838
SGTC_1594 piperine 70.1 µM 1.45298580118454 0.157528426358487 no 579 0.0731138481695393 470 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_724 3910-0327 137 µM 1.45227872294834 0.157680470425307 no 580 0.0732120605778284 475 2885483
SGTC_1855 st056195 39.6 µM 1.45190866190218 0.157760083611304 no 581 0.0732635018807708 447 4028379
SGTC_647 0140-0236 81 µM 1.45114790684586 0.15792383177633 no 582 0.0733693394706906 507 990837
SGTC_1405 3909-7894 12 µM 1.45023995315748 0.158119409632441 no 583 0.0734958086249749 433 7104060
SGTC_1920 st075728 45.7 µM 1.44879977028814 0.158429958309962 no 584 0.0736967539837662 439 3400306
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.44614362560026 0.159003755247989 no 585 0.074068460874489 434 6710655
SGTC_845 0330-0138 4.51 µM 1.44517219716613 0.159213948921425 no 586 0.074204761879481 452 9039800
SGTC_471 1-acyl-paf 4 µM 1.44510447326155 0.159228609523213 no 587 0.0742142713507369 441 16759367
SGTC_3146 9095609 49.47 µM 1.44258207250806 0.159775278511497 no 588 0.0745691182628471 433 17173999
SGTC_908 3448-7491 47.7 µM 1.4418100742024 0.159942835483402 no 589 0.0746779800523994 567 1203031
SGTC_77 0828-0286 12.516 µM 1.4415851575161 0.159991673728255 no 590 0.0747097190302833 477 745345
SGTC_1508 1080-0625 72.9 µM 1.44102218695392 0.16011395949457 no 591 0.0747892073971759 410 767111
SGTC_2841 9004761 38.96 µM 1.43900499507058 0.160552625865008 no 592 0.0750745537581767 413 2991039
SGTC_123 0083-0120 66.675 µM 1.4387994530217 0.160597367867762 no 593 0.0751036757113376 479 16001701
SGTC_2471 5466956 24.79 µM 1.43765505407453 0.160846627345519 no 594 0.0752659758858669 415 724419
SGTC_2826 7992541 19.48 µM 1.43746052872381 0.160889021663966 no 595 0.075293590296453 440 2985066
SGTC_111 0083-0039 52.457 µM 1.43697860037003 0.160994083218564 no 596 0.0753620371030886 286 759313
SGTC_371 0195-0006 7.36 µM 1.43098932913084 0.162303494034412 no 597 0.0762166367079256 383 3928593
SGTC_590 k048-0076 22.4 µM 1.4299639124795 0.162528369995616 no 598 0.0763636883937742 456 6832814
SGTC_1019 4262-0212 3.4 µM 1.42682505854822 0.16321798653662 no 599 0.0768151631737429 561 4677213
SGTC_3075 9116269 49.47 µM 1.42646693049669 0.163296789116357 no 600 0.0768668029732647 460 17015205 YNL244C SUI1
SGTC_1118 chelidonine 707.474 nM 1.42589378553117 0.163422955493801 no 601 0.076949501761783 500 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_913 3487-1245 167 µM 1.42508557088586 0.163600975313729 no 602 0.0770662335339052 480 4016153
SGTC_254 nsc-64875 3.808 µM 1.42112098947966 0.164476049036458 no 603 0.0776407945054891 450 56993
SGTC_3222 9128301 49.47 µM 1.41894505984234 0.164957613535365 no 604 0.0779575170204542 457 4911358
SGTC_486 niguldipine 82 µM 1.4186420774201 0.165024740243287 no 605 0.0780016959808627 398 1236 A calcium channel blocker.
SGTC_3303 9125618 40.5795 µM 1.41439809533349 0.165966866350138 no 606 0.0786225245101307 569 22695467
SGTC_82 0054-0107 293.755 µM 1.41377055789675 0.166106468457569 no 607 0.0787146404105347 426 3104697
SGTC_261 5-fluorouridine 15.376 µM 1.41266194847981 0.166353275271653 no 608 0.0788775724470752 468 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1319 1306-0155 43.7 µM 1.40954072176676 0.167049416970833 no 609 0.0793376705624065 532 3122360
SGTC_575 k072-0246 11.9 µM 1.40345733787245 0.168411612627675 no 610 0.0802402526090464 488 6796779
SGTC_24 0417-1663 219 µM 1.40205499962421 0.168726635495151 no 611 0.0804494117519117 464 4329390
SGTC_3280 9140961 49.47 µM 1.40101441201162 0.168960638888051 no 612 0.0806048817211625 449 4901226
SGTC_2513 baicalein 25.65 µM 1.40077210031939 0.169015158931201 no 613 0.0806411170795592 471 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1677 st019204 53.9 µM 1.39890754046475 0.169435062162941 no 614 0.0809203555489549 455 3945625
SGTC_875 0709-0210 25.7 µM 1.39644902947429 0.169989746972835 no 615 0.0812896597029273 531 6251364
SGTC_1005 4092-0690 4.4 µM 1.39601840770986 0.170087022741335 no 616 0.0813544760151652 468 1529343
SGTC_1887 st057648 70.8 µM 1.39598911552635 0.170093641026426 no 617 0.0813588864307495 481 688672
SGTC_2036 5160441 105 µM 1.39501581161976 0.170313643462063 no 618 0.0815055357736163 561 134534 YIL048W NEO1
SGTC_3297 9117502 71.43 µM 1.39022339626621 0.17139956230824 no 619 0.0822305255096841 449 7453720
SGTC_2285 7945142 200 µM 1.38755155189519 0.172006895730094 no 620 0.0826368214551891 483 2970608
SGTC_3325 9138760 55.175 µM 1.38346710592029 0.172937977572614 no 621 0.0832608433338045 491 43844959
SGTC_70 0141-0289 43.283 µM 1.38045213087961 0.173627321227079 no 622 0.0837237393531834 717 352408
SGTC_1885 st057546 99.9 µM 1.37711255844425 0.17439291864042 no 623 0.0842387252795997 520 702008
SGTC_802 4112-3352 742 µM 1.3746145797411 0.174966980388272 no 624 0.0846254830511198 552 704594
SGTC_2828 7998861 71.43 µM 1.37239461210739 0.175478157374902 no 625 0.0849703132458489 401 2988188
SGTC_511 blebbistatin 171 µM 1.37110782577755 0.175774889920399 no 626 0.0851706728947646 481 3476986 A myosin inhibitor.
SGTC_1880 MG-132 525 µM 1.36865070226647 0.176342384238504 no 627 0.0855542435066119 454 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3344 9148862 3.898 µM 1.36388361245593 0.177446687642466 no 628 0.0863020996291185 504 4905352
SGTC_2047 4141938 200 µM 1.3637520000059 0.177477237658718 no 629 0.0863228159861434 431 3807862
SGTC_1316 1272-0050 65.9 µM 1.36360178273156 0.177512110302731 no 630 0.0863464653656289 498 7340392
SGTC_45 0kpi-0036 14.9 µM 1.36021097644572 0.178300429698725 no 631 0.0868815850320491 460 2795021
SGTC_1324 1418-0026 34.4 µM 1.36015811085743 0.178312737716277 no 632 0.0868899475794425 524 1372513
SGTC_1664 st014217 9.02 µM 1.35953598891985 0.17845761861466 no 633 0.0869884031706267 521 3982782
SGTC_3203 9113543 49.47 µM 1.35887649207826 0.178611284396626 no 634 0.087092864595481 500 17018012
SGTC_1784 st039334 36.3 µM 1.35171283933968 0.180285813193501 no 635 0.0882335980658517 503 3496984
SGTC_1327 1436-0082 2.18 µM 1.34761863841716 0.181247256581531 no 636 0.0888905363509079 495 15992205
SGTC_1985 st071382 65.5 µM 1.34686802463215 0.181423871308279 no 637 0.0890113706817229 503 6123237
SGTC_3139 9095020 49.47 µM 1.34517270142341 0.18182316656498 no 638 0.089284734845743 372 25236292
SGTC_2781 5567276 71.43 µM 1.34467975838437 0.181939371290354 no 639 0.0893643370529288 510 2853274
SGTC_1086 cerivastatin 2.18 µM 1.34407753102681 0.182081401346211 no 640 0.0894616585161735 481 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3187 9109394 49.47 µM 1.33981177015132 0.183089427144973 no 641 0.090153274036844 546 17098090
SGTC_1161 k007-0610 110 µM 1.33916741238002 0.1832419949836 no 642 0.0902580893013866 639 5843850
SGTC_415 dibenzyl ketone 100 µM 1.3387509874614 0.183340636175876 no 643 0.0903258757146788 520 7593
SGTC_2541 muurolladie-3-one 83.07 µM 1.33799049190832 0.183520864969517 no 644 0.0904497681375727 514 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_171 k064-0041 9.68 µM 1.33643393129331 0.183890096289692 no 645 0.0907037409514236 423 53325
SGTC_984 1492-0255 2.91 µM 1.33607966190676 0.183974197021772 no 646 0.0907616184081523 482 1585198
SGTC_2912 7964298 10.93 µM 1.33396770504599 0.184476055588231 no 647 0.0911072203699121 599 2975850
SGTC_1484 3473-2379 286 µM 1.33281100090064 0.184751280606497 no 648 0.0912969173415616 622 671917
SGTC_3017 9080681 49.47 µM 1.3316852161307 0.185019393675941 no 649 0.0914818246457604 503 16451914
SGTC_2851 9015922 71.43 µM 1.33027549178046 0.185355469516166 no 650 0.0917137595268595 532 2996893
SGTC_78 0336-0123 156.75 µM 1.32693518160511 0.186153305387679 no 651 0.0922650626004358 476 6765896
SGTC_2064 5220758 200 µM 1.32590244156293 0.186400406333151 no 652 0.0924360070851263 578 788518
SGTC_673 1082-0474 110 µM 1.32254505109557 0.187205123199842 no 653 0.0929933590087177 643 3098046
SGTC_72 0744-0168 198.391 µM 1.32002530752951 0.187810477456716 no 654 0.0934132842999266 517 677577
SGTC_1296 1068-0102 11.9 µM 1.31961171123471 0.187909957024942 no 655 0.0934823453839021 535 767053
SGTC_383 2324-0395 7.37 µM 1.31794358968016 0.188311509351678 no 656 0.0937612661534889 545 3146421
SGTC_2409 alverine citrate 63.97 µM 1.31700868500182 0.18853679209489 no 657 0.093917856695071 546 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1776 st049249 45.9 µM 1.31269571453652 0.189578233102688 no 658 0.0946427511224688 561 1822314
SGTC_3053 9095903 49.47 µM 1.31164381457104 0.189832768327227 no 659 0.0948201711668952 513 17174018
SGTC_1454 4239-0054 42.6 µM 1.31162288066598 0.189837835975017 no 660 0.0948237044960986 589 1340767
SGTC_2120 5538279 151.968 µM 1.31109764709598 0.189965010940819 no 661 0.0949123878020075 529 2058197
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.30981934076529 0.190274746413926 no 662 0.0951284793357098 577 5106787 A p450 inhibitor.
SGTC_3235 9132602 49.47 µM 1.30894147635467 0.190487633804427 no 663 0.0952770878035048 575 4912240
SGTC_533 1222-0222 6.71 µM 1.30837337020305 0.190625480873601 no 664 0.0953733501883426 587 3982874
SGTC_1203 3992-3522 103 µM 1.30825534092498 0.190654127550481 no 665 0.0953933585636976 583 5322312
SGTC_1411 3909-8223 150 µM 1.30747889079145 0.190842644245845 no 666 0.0955250597622417 553 X1411
SGTC_39 0986-0283 58.349 µM 1.30413070299503 0.191656870102509 no 667 0.0960945110445297 611 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2856 9022925 19.48 µM 1.30167709735322 0.1922548965757 no 668 0.0965133959809368 558 4944862
SGTC_429 1112-0049 25.5 µM 1.30037508023463 0.192572705095471 no 669 0.0967362232837211 512 2836170
SGTC_534 k292-0788 63.4 µM 1.30016772273338 0.192623348480546 no 670 0.0967717453103347 604 4146317
SGTC_2478 5763493 32.33 µM 1.29863982951214 0.192996760151373 no 671 0.0970337812144441 556 1365576 YLR208W SEC13
SGTC_1180 1193-0155 285 µM 1.29799849576936 0.193153631466043 no 672 0.0971439259342272 516 2921347
SGTC_2167 5876490 200 µM 1.29640569870483 0.193543568893962 no 673 0.0974178748932817 546 686534
SGTC_2161 5662504 8.5105 µM 1.29489150296096 0.193914708534876 no 674 0.097678830054918 527 2859334
SGTC_1768 st044301 37.178 µM 1.29399968264122 0.194133502557576 no 675 0.0978327652141558 567 3931349
SGTC_1512 0259-0544 12.2 µM 1.2931880286655 0.194332759685494 no 676 0.0979730175311404 592 18476
SGTC_1574 spiramycin 23.7 µM 1.29310127411966 0.194354064870994 no 677 0.0979880172692463 558 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2811 7967822 32.47 µM 1.29223472059571 0.194566951163226 no 678 0.0981379355108651 556 2232244
SGTC_333 3486-0131 40.1 µM 1.28897572330222 0.195368858972938 no 679 0.0987032632828151 550 6744690
SGTC_2495 cafestol 54.53 µM 1.28813528206087 0.195575982864444 no 680 0.0988494377495219 512 16667697 An anti-infammatory.
SGTC_831 k061-1017 217 µM 1.28798246717707 0.195613657894786 no 681 0.0988760332198854 726 1240153
SGTC_3342 9147791 14.508 µM 1.28772919016795 0.195676110592809 no 682 0.0989201243635483 547 1838168
SGTC_1241 0364-0022 50.8 µM 1.28517982103043 0.196305404412221 no 683 0.0993647267002106 590 4563895
SGTC_579 4491-1009 110 µM 1.28478771488726 0.196402301798829 no 684 0.0994332382544142 697 1271041
SGTC_2658 polymyxin b sulfate 77.05 µM 1.28444916243108 0.196485988298339 no 685 0.0994924203022771 581 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2383 9036125 200 µM 1.28378312559378 0.196650688447407 no 686 0.0996089247352321 513 79580
SGTC_88 0180-0332 8.668 µM 1.28357146836067 0.196703045367323 no 687 0.099645969087617 557 3101745
SGTC_586 0957-0265 8.15 µM 1.28356719695318 0.196704102057573 no 688 0.099646716775055 465 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2240 6690706 185.951 µM 1.28213409468092 0.197058826848485 no 689 0.0998978052650873 462 805876
SGTC_512 prima-1 270 µM 1.28123428620207 0.197281747246595 no 690 0.100055693316394 588 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_439 amiodarone 34.4 µM 1.28017023497986 0.197545554238645 no 691 0.100242635832067 623 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_285 1486-1325 46 µM 1.27971970654246 0.197657316623316 no 692 0.100321865680916 592 22310230
SGTC_1446 4239-0190 62 µM 1.27450641830493 0.198953352447695 no 693 0.101241999734252 619 1340085
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.2741253292077 0.199048292546803 no 694 0.10130950152967 589 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_312 4092-0653 6.84 µM 1.27335589461211 0.1992400636984 no 695 0.101445890361314 660 1148278
SGTC_1076 itraconazole 331 nM 1.27197790628018 0.199583786593897 no 696 0.101690484676134 573 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3085 9117376 49.47 µM 1.27077076666794 0.199885186333331 no 697 0.101905105752071 565 16480349
SGTC_2650 prasterone 100 µM 1.26739620624743 0.200729200690497 no 698 0.10250682782014 474 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_650 1328-0195 38 µM 1.26729200086088 0.200755297597225 no 699 0.102525449840131 588 2780821
SGTC_1360 1598-0022 39.8 µM 1.26637647128933 0.200984667804552 no 700 0.102689165257678 659 761525
SGTC_2884 9058502 51.95 µM 1.26609557436103 0.201055073209737 no 701 0.102739433445835 586 6471554
SGTC_2017 5132927 60.65 µM 1.26592691614019 0.201097353653061 no 702 0.10276962443586 570 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_229 benomyl 22.8748 µM 1.26563718947403 0.201169996843143 no 703 0.102821502565872 599 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1464 k208-0027 110 µM 1.26546629382495 0.20121285290014 no 704 0.102852111869199 592 X1464
SGTC_2198 6589944 200 µM 1.26458948626125 0.201432818860717 no 705 0.10300926194528 461 5290268
SGTC_1633 st005664 67.9 µM 1.26192454607615 0.20210226027612 no 706 0.10348796926657 592 2063822
SGTC_2649 anisomycin 9.56 µM 1.25842512669667 0.202983344527248 no 707 0.10411902475745 523 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3276 9139060 49.47 µM 1.25837484928794 0.202996020072206 no 708 0.104128111641382 516 4870619
SGTC_738 1315-0003 72.4 µM 1.25733473175739 0.203258352350451 no 709 0.104316226203821 612 6251474
SGTC_2319 6033012 152.6 µM 1.25598328628183 0.203599507984976 no 710 0.104561014955277 511 847246
SGTC_409 arachidonic acid 100 µM 1.25558277642506 0.203700677284469 no 711 0.104633639601009 591 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1065 prochlorperazine maleate 2.48 µM 1.25486023172997 0.203883268787551 no 712 0.104764751381684 595 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3227 9130768 49.47 µM 1.25459824585583 0.203949498322901 no 713 0.104812320288227 568 17720899
SGTC_2049 5262831 67.185 µM 1.25441782640954 0.203995115472227 no 714 0.104845088230195 587 763417
SGTC_899 1083-0020 478 µM 1.25424630963726 0.204038487310711 no 715 0.10487624613748 596 767123
SGTC_2973 9094665 17.96 µM 1.25182214114141 0.204652079682374 no 716 0.105317340169677 636 25237061 YIL048W NEO1
SGTC_1179 1021-1431 9.29 µM 1.2471186737837 0.205845722419521 no 717 0.106176993398727 635 2840958
SGTC_664 1222-0054 14.9 µM 1.2458983880585 0.206156079211833 no 718 0.106400850980414 607 6813991
SGTC_1036 k216-0215 33.5 µM 1.2445045005115 0.206510927587053 no 719 0.106656972011827 619 622330
SGTC_733 4069-0007 56.1 µM 1.24327005853876 0.206825487068055 no 720 0.106884166862541 654 5717425 YNL287W SEC21
SGTC_1995 st072814 61.1 µM 1.24266210482277 0.206980509513549 no 721 0.106996186914333 570 5769371
SGTC_1828 st055811 49 µM 1.24223059937619 0.207090581027706 no 722 0.107075746411594 530 5877589
SGTC_2322 7413319 38.22 µM 1.24200775074005 0.207147440418841 no 723 0.107116851183712 726 1840400
SGTC_3212 9128307 49.47 µM 1.24055106981391 0.207519337096047 no 724 0.107385818538857 514 27243542
SGTC_707 0865-0008 204 µM 1.24025448823101 0.207595103923948 no 725 0.107440640138776 607 723043
SGTC_1439 4092-1168 46 µM 1.23861317962313 0.20801469967214 no 726 0.107744392432783 597 2886240
SGTC_2827 7993847 71.43 µM 1.23834612780785 0.208083018014072 no 727 0.107793873407491 530 2985692
SGTC_1810 st050138 53 µM 1.23762399453766 0.208267823560319 no 728 0.107927756594246 542 3444541
SGTC_3286 9117135 37.221 µM 1.23684889912558 0.208466290681011 no 729 0.108071592139707 567 3438150
SGTC_3102 9121669 49.47 µM 1.23549969545768 0.208812027055813 no 730 0.108322294866537 541 41905072
SGTC_1368 1852-0141 284 µM 1.23225710278631 0.209644328973351 no 731 0.10892652928929 572 2838987
SGTC_1752 st044819 83.042 µM 1.22848882873256 0.210614008558694 no 732 0.109631760225527 590 441209 YML126C ERG13
SGTC_346 4513-0042 7.16 µM 1.22664562554395 0.21108927182361 no 733 0.109977906377499 616 2827372
SGTC_2569 tetrandrine 100 µM 1.22490848499999 0.211537762052891 no 734 0.110304851557056 535 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1225 1216-0074 20.6 µM 1.22449215886565 0.211645330821858 no 735 0.110383311244805 591 4241466
SGTC_3266 9136860 49.47 µM 1.2229299780424 0.212049246552094 no 736 0.110678072350031 598 4871271 YPR165W RHO1
SGTC_1391 3442-0225 151 µM 1.22114478855672 0.212511374603773 no 737 0.111015602112745 542 5227075
SGTC_2984 9022109 38.96 µM 1.21862176462948 0.213165506512479 no 738 0.111493892199391 558 6459207
SGTC_2404 5161160 200 µM 1.21726695063689 0.213517246491006 no 739 0.111751332209797 636 2831543
SGTC_2920 7982904 15.77 µM 1.21597049360378 0.213854152175701 no 740 0.111998081155771 542 6456808
SGTC_629 3448-6466 76.7 µM 1.21546075535162 0.213986700777585 no 741 0.1120952039983 630 573744
SGTC_2299 7976368 114.88 µM 1.21412875700971 0.214333289544523 no 742 0.112349280131325 587 2979718
SGTC_1514 1189-1591 158 µM 1.21324684657742 0.214562944034465 no 743 0.112517729115964 647 767698 YMR146C TIF34
SGTC_2227 7312221 64.1025 µM 1.21294929645174 0.214640460039363 no 744 0.11257460325296 573 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3134 9127454 49.47 µM 1.21256850607253 0.214739685043794 no 745 0.112647417994711 605 24262820
SGTC_2936 9038235 15.59 µM 1.21113521699838 0.215113405307917 no 746 0.112921793101704 593 4749415
SGTC_400 oxethazaine 37.5 µM 1.21106187744897 0.215132538240027 no 747 0.112935845339266 590 4621 A local anesthetic.
SGTC_1975 st070967 30.8 µM 1.20897204452888 0.215678152019164 no 748 0.1133367928118 685 261391
SGTC_921 1561-0023 372 µM 1.20892090755127 0.215691512914041 no 749 0.11334661646966 623 24050882
SGTC_3300 9124615 50.48 µM 1.20876952953321 0.215731067258218 no 750 0.113375700470549 598 24824903
SGTC_813 k007-0158 173 µM 1.20827606345618 0.21586003674943 no 751 0.113470546222997 680 6523916
SGTC_2689 tacrolimus 100 µM 1.20787682046352 0.215964413321071 no 752 0.11354732339533 584 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2229 7354935 190 µM 1.20758579788668 0.216040515580552 no 753 0.113603312373817 542 318112
SGTC_2165 5727197 32.143 µM 1.20688976069502 0.21622259195359 no 754 0.113737300748938 596 1361712
SGTC_166 k072-0058 166.424 µM 1.20680465518772 0.216244860798194 no 755 0.113753691432933 623 5846229
SGTC_565 1418-0001 44.5 µM 1.20652937689054 0.216316899655601 no 756 0.113806719503152 660 2862145
SGTC_1916 st067606 49.2 µM 1.20641589624954 0.216346600975588 no 757 0.113828584906112 662 19590279
SGTC_2607 solasodine 47.35 µM 1.20389554349096 0.21700686176575 no 758 0.114314977248089 632 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3177 9107506 49.47 µM 1.20359383022013 0.217085980039747 no 759 0.114373302664943 565 8897194
SGTC_1477 0139-0234 16 µM 1.20346857557558 0.217118830461724 no 760 0.114397522371212 616 620880
SGTC_867 0518-0118 155 µM 1.20324388714869 0.217177766488157 no 761 0.114440978114787 621 6848158
SGTC_3167 9103034 49.47 µM 1.20275254458397 0.217306678390693 no 762 0.11453604690052 542 5127859
SGTC_811 0416-0114 265 µM 1.20113865772313 0.217730419304607 no 763 0.114848709811585 596 6612453
SGTC_1189 1431-2119 7.28 µM 1.20063886668554 0.21786174066723 no 764 0.114945658770966 648 3107275
SGTC_2712 st079126 47.7 µM 1.19996442218861 0.218039025062101 no 765 0.115076579084026 569 3152970
SGTC_3031 9088762 49.47 µM 1.19996392946071 0.218039154610889 no 766 0.115076674769027 634 205253
SGTC_3236 9132701 49.47 µM 1.19885177879954 0.218331676058916 no 767 0.115292792398732 616 24282524
SGTC_2666 tannic acid 100 µM 1.19862013909415 0.218392631115402 no 768 0.115337841844827 671 16134267 A thiamine antagonist.
SGTC_149 3970-0822 46.1 µM 1.1984827375414 0.218428792412267 no 769 0.115364569702303 767 3114250 YBL034C STU1
SGTC_2027 5150920 200 µM 1.19846790804741 0.218432695439935 no 770 0.115367454653408 617 786715
SGTC_2312 7706453 155.7 µM 1.19810621738781 0.218527902536935 no 771 0.115437834351475 616 976098
SGTC_3232 9132874 49.47 µM 1.19802927950395 0.218548157821204 no 772 0.115452809269879 588 3784940
SGTC_889 0919-1524 82.7 µM 1.19673815164095 0.21888823174212 no 773 0.115704315822543 588 3905452
SGTC_3308 9128332 17.569 µM 1.1941133436776 0.219580525280102 no 774 0.116216817121934 713 17332805 YDL196W YDL196W
SGTC_2815 7968870 71.43 µM 1.19301646424316 0.219870199559882 no 775 0.116431462539821 654 2977326 YHR190W ERG9
SGTC_2991 9074669 71.4286 µM 1.19282237497047 0.219921479316035 no 776 0.116469472617185 691 17333109
SGTC_781 4335-2806 94.4 µM 1.19197766252089 0.220144738227983 no 777 0.116635002021742 716 845254
SGTC_2256 7954252 200 µM 1.19097212015847 0.220410674150079 no 778 0.1168322649727 527 2972920
SGTC_2589 lobaric acid 100 µM 1.19055862769527 0.220520083961099 no 779 0.116913450717033 618 73157 A novel microtubule depolymerizer.
SGTC_523 1934-0222 13.7 µM 1.18967976749228 0.220752733082478 no 780 0.117086140266731 635 1361595
SGTC_2964 9083345 53.42 µM 1.1876458744061 0.221291677613608 no 781 0.117486478150078 576 17741579
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.18730877631999 0.221381075094601 no 782 0.117552923793039 546 4620898
SGTC_1244 0416-0015 52.5 µM 1.18483622925377 0.222037418658352 no 783 0.118041102566915 607 96201
SGTC_2702 st077768 96.8 µM 1.18376291103258 0.222322678986361 no 784 0.1182534638565 573 6484119
SGTC_2013 4024628 200 µM 1.18261600066954 0.222627729151154 no 785 0.118480684106074 576 5230760
SGTC_1864 st057645 30.4 µM 1.18238417470827 0.22268941817534 no 786 0.1185266497921 601 688666
SGTC_856 0433-0016 11.3 µM 1.18141562245545 0.222947255858072 no 787 0.118718827447142 664 3911780
SGTC_938 3126-1755 342 µM 1.17996930016851 0.22333259677909 no 788 0.119006212630037 678 1777771
SGTC_2959 9079155 11 µM 1.17839096135727 0.223753542770486 no 789 0.119320389719015 560 16189457
SGTC_3045 9092950 49.47 µM 1.17758443355082 0.223968819294565 no 790 0.11948115932872 685 44120432
SGTC_2757 clomiphene 4.22 µM 1.17031725643122 0.225913856708859 no 791 0.120936659977839 742 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3037 9091026 49.47 µM 1.16914786595364 0.226227730128598 no 792 0.12117203081201 749 25236398 YIL048W NEO1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.166504366232 0.22693817307171 no 793 0.12170529215278 660 688664
SGTC_535 2293-4129 48.2 µM 1.16625461098412 0.227005360016116 no 794 0.121755759288258 731 396118 YIL048W NEO1
SGTC_1653 st012112 65 µM 1.16619700956776 0.227020857030505 no 795 0.121767400683528 617 720429
SGTC_300 r073-0011 5.04 µM 1.16260946003697 0.227987221786612 no 796 0.122493995421283 725 2735780
SGTC_1670 st016595 4.04 µM 1.16242508495274 0.228036948647213 no 797 0.122531419355301 652 597879
SGTC_531 3788-1495 174 µM 1.15979049294811 0.228748176985576 no 798 0.123067057875394 640 2896655
SGTC_1072 oxiconazole 14.9 nM 1.15800360227141 0.229231269763796 no 799 0.123431283187426 688 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2025 5147754 141 µM 1.15726182439066 0.229431980183543 no 800 0.123582702754168 631 315777 YLR208W SEC13
SGTC_3067 9117431 49.47 µM 1.15695021480882 0.229516324940939 no 801 0.123646350592449 594 17150885
SGTC_3091 9116372 49.47 µM 1.15680432442519 0.22955581971331 no 802 0.123676157331222 596 17169793
SGTC_2963 9082507 9 µM 1.15612182864117 0.229740632390945 no 803 0.123815664278241 615 16459611
SGTC_2474 5321570 43.32 µM 1.15599671988693 0.229774519560128 no 804 0.123841249331839 629 2841384
SGTC_1343 1487-0095 224 µM 1.15486915192432 0.230080060788186 no 805 0.124072006790558 640 4560101 YGL055W OLE1
SGTC_1729 st035615 45.989 µM 1.15368896486897 0.230400103752837 no 806 0.124313854841466 637 17385451
SGTC_614 0462-0418 107 µM 1.15219442864923 0.230805748799692 no 807 0.124620593293334 592 5188303
SGTC_2834 9001755 58.44 µM 1.15079679595828 0.23118545305906 no 808 0.124907921623686 597 2989575
SGTC_2525 harmine 47.85 µM 1.14929059585244 0.231595042460759 no 809 0.125218087276284 600 5280953 A monoamine oxidase inhibitor
SGTC_903 1134-0042 114 µM 1.14891456689464 0.231697361170746 no 810 0.125295605205419 642 701009
SGTC_2307 7538926 6.34 µM 1.14868900633996 0.231758749020347 no 811 0.125342120322258 682 96582
SGTC_3351 9150312 21.596 µM 1.14527204185834 0.23268980689705 no 812 0.126048241820443 674 4904905
SGTC_2581 avocatin a 64 µM 1.14525833222632 0.232693546693767 no 813 0.12605108051404 691 6710728 A skin care supplement.
SGTC_2195 6536160 144.242 µM 1.1449283719203 0.232783565347735 no 814 0.126119414991807 594 3834386
SGTC_1914 st062367 72.6 µM 1.14489992125177 0.232791328068923 no 815 0.126125308308378 627 978205
SGTC_1195 1502-0147 41.1 µM 1.14361636032842 0.233141695288534 no 816 0.12639138686941 690 817940
SGTC_2704 st078022 71.1 µM 1.14059831557316 0.233966668179122 no 817 0.127018559270866 673 54697681
SGTC_2052 5265182 7.135 µM 1.13938367711216 0.234299141549409 no 818 0.127271580526072 692 1239884
SGTC_1220 1838-0075 193 µM 1.13917032276281 0.234357568335727 no 819 0.127316060533702 688 5529645
SGTC_2719 novobiocin 32.65 µM 1.13836527635219 0.234578101751085 no 820 0.127483993577789 594 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2398 5228213 48.84 µM 1.13645695656225 0.235101322740048 no 821 0.127882685075925 770 80771 YMR134W ERG29
SGTC_2345 9052315 157.45 µM 1.13434415673557 0.235681358974404 no 822 0.128325106814797 653 6469265
SGTC_2767 sibutramine 71.45 µM 1.13365734568303 0.235870082076973 no 823 0.128469154132715 688 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1062 mesoridazine 14.2 µM 1.13341870456899 0.235935675781937 no 824 0.12851923144459 693 4078 A neuroleptic.
SGTC_1335 1486-0900 202 µM 1.13186872505859 0.236361953012142 no 825 0.128844814500598 703 X1335
SGTC_1471 k673-0312 37 µM 1.13180760817411 0.236378770135964 no 826 0.128857664205149 664 24099884
SGTC_1980 st071811 45.7 µM 1.13021777974096 0.236816463932844 no 827 0.12919223484074 667 4974850
SGTC_22 0964-0034 14.468 µM 1.12736306453588 0.237603509566921 no 828 0.129794504338249 713 138402
SGTC_3089 9117425 49.47 µM 1.12720485553565 0.237647169762837 no 829 0.129827939023743 615 9401657
SGTC_1188 1403-0014 4.57 µM 1.12526755489793 0.238182154348244 no 830 0.130237837033912 744 9614867
SGTC_981 1488-1094 54.9 µM 1.1243903597825 0.238424608196129 no 831 0.130423729958154 619 3449522
SGTC_481 bay k-8644 50 µM 1.12300433390502 0.238807976497969 no 832 0.130717826908004 631 2303 A calcium channel antagonist.
SGTC_1708 st033234 31.827 µM 1.12167291494524 0.23917655807684 no 833 0.131000768370962 736 674664
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.12068036613633 0.23945153112519 no 834 0.131211971240127 681 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2113 5491891 107.031 µM 1.12059938912003 0.239473972393604 no 835 0.131229212579708 694 789979
SGTC_1871 st057448 67.3 µM 1.11916070968713 0.239872866930421 no 836 0.131535791968013 722 691747
SGTC_2314 7727897 200 µM 1.11709534528191 0.24044615193791 no 837 0.131976780259681 655 900724
SGTC_2368 9071271 200 µM 1.11622030199825 0.240689263329849 no 838 0.132163923156528 661 27209959
SGTC_2662 daunorubicin 22.37 µM 1.11351131086279 0.241442743995972 no 839 0.132744446624638 653 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1749 st037932 54.2 µM 1.11278861138852 0.241643972409009 no 840 0.132899613868029 652 594497
SGTC_3074 9116018 49.47 µM 1.11130353487965 0.242057762679884 no 841 0.133218859184755 643 17027303
SGTC_2019 4016004 108 µM 1.11048358950174 0.242286390478946 no 842 0.133395347901375 626 45595336
SGTC_2654 protoveratrine a 100 µM 1.10931288139506 0.242613025222761 no 843 0.133647615014187 677 5702278 A heart drug and vasodilator.
SGTC_3199 9111318 49.47 µM 1.1085115537393 0.242836737940659 no 844 0.133820476089949 710 8548020
SGTC_2687 chenodiol 100 µM 1.10553181405432 0.243669592912774 no 845 0.134464608472251 664 5702181 A cholesterol synthesis inhibitor.
SGTC_1945 st075991 56.6 µM 1.1048929743628 0.243848352971611 no 846 0.134602983529024 641 1084980
SGTC_1482 3346-2049 8.48 µM 1.10365343011722 0.244195403909704 no 847 0.134871752152958 673 3826804
SGTC_2092 5303694 80.6725 µM 1.10285543814447 0.244418968684104 no 848 0.135044974296505 724 1963699
SGTC_2236 dapsone 200 µM 1.10048084470282 0.245084884711717 no 849 0.135561335583686 744 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1295 1013-0063 9.78 µM 1.1003554156507 0.245120086358641 no 850 0.135588648008314 728 6826038
SGTC_2035 5154463 94.595 µM 1.09903959921508 0.245489533901815 no 851 0.135875396872072 717 2769623
SGTC_2077 5212015 200 µM 1.09802473031478 0.245774687319127 no 852 0.136096845301478 661 780900
SGTC_2977 9011197 71.43 µM 1.09730485459951 0.245977062594704 no 853 0.136254074727727 633 2704722
SGTC_1041 0206-0046 107 µM 1.09471031387603 0.246707194883351 no 854 0.136821784319368 701 50494
SGTC_963 1269-2853 151 µM 1.09447437339546 0.246773648647429 no 855 0.136873490371651 660 3668223
SGTC_2470 5664817 21.68 µM 1.09326133362213 0.247115458341351 no 856 0.137139537305433 713 2859561
SGTC_355 1311-2252 105 µM 1.09239853380342 0.247358731641709 no 857 0.137328983593718 707 5338538
SGTC_1255 0566-0045 221 µM 1.08708682654921 0.248859225694117 no 858 0.138499219588184 717 2788469
SGTC_1932 st074806 40.9 µM 1.08663853141181 0.248986085078565 no 859 0.13859829467657 762 17251235
SGTC_1128 3448-9350 235 µM 1.08577351353948 0.249230966660373 no 860 0.138789603668398 638 619386
SGTC_3142 9086498 49.47 µM 1.08576273347766 0.249234019241621 no 861 0.138791988941338 674 25236367
SGTC_1219 1469-0211 33.1 µM 1.08572185759116 0.249245594213429 no 862 0.138801033683549 694 6822282
SGTC_395 anisomycin 6.25 µM 1.08463336161044 0.24955393266377 no 863 0.139042036457007 649 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2329 6138490 200 µM 1.08455319925277 0.249576648278288 no 864 0.139059796376842 624 720019
SGTC_620 0109-0052 432 µM 1.08413727010374 0.249694527792589 no 865 0.139151970009057 744 493037
SGTC_140 0062-0056 502.533 µM 1.08343680570203 0.24989311496082 no 866 0.139307293168271 762 3758964
SGTC_3172 9105863 49.47 µM 1.08306104972335 0.249999679274407 no 867 0.139390663064518 649 2348785
SGTC_2407 paclitaxel 400 µM 1.08300496046671 0.250015588243475 no 868 0.139403110635627 747 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3347 9188721 44.724 µM 1.08254981661271 0.250144703586131 no 869 0.139504146097546 690 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_54 0159-0055 9 µM 1.08247548385082 0.250165793685175 no 870 0.139520651643505 717 3319099
SGTC_2699 st077704 54.6 µM 1.07996618106758 0.250878299780923 no 871 0.140078620129908 713 645852
SGTC_353 1988-1175 58.3 µM 1.07939223679244 0.251041419686321 no 872 0.140206455105885 672 2788357
SGTC_1068 loratadine 26.9 µM 1.07922080727968 0.25109015231136 no 873 0.140244653075418 690 3957 A H1 histamine antagonist.
SGTC_3157 9099274 49.47 µM 1.07892003685219 0.25117566503915 no 874 0.140311687899977 709 17217662
SGTC_2677 mitomycin C 100 µM 1.07793164590148 0.251456785170126 no 875 0.140532130786726 675 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1408 3909-7976 48.8 µM 1.07783808383337 0.251483404892908 no 876 0.140553010303549 786 24152374
SGTC_1755 st041960 45.185 µM 1.07682512423704 0.251771701438361 no 877 0.140779199409058 725 2257073
SGTC_2058 5236698 133 µM 1.07556269915497 0.25213124200571 no 878 0.141061438521457 708 766665
SGTC_669 0108-0021 26.2 µM 1.0747280657801 0.252369095479641 no 879 0.141248247246195 846 17201
SGTC_178 4092-0806 87.505 µM 1.07340852495522 0.252745378855708 no 880 0.141543930626741 790 2169044
SGTC_2279 7948423 32.93 µM 1.07226759240217 0.253070967864377 no 881 0.141799929222944 669 1247112
SGTC_2565 isoliquiritigenin 100 µM 1.07213468158009 0.253108911096314 no 882 0.141829771683208 580 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2606 farnesol 9.78 µM 1.07200487788142 0.253145970198286 no 883 0.141858920606042 745 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_426 0988-0037 14.6 µM 1.07168555654754 0.253237148942726 no 884 0.141930645170871 797 5383008
SGTC_1558 st069300 45.6 µM 1.0716265306479 0.253254005039205 no 885 0.141943905999231 660 24208000
SGTC_2528 xanthyletin 44.79 µM 1.0703533281659 0.253617738545637 no 886 0.142230149373262 728 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1334 1486-0610 236 µM 1.07012690434491 0.253682452922331 no 887 0.142281095211396 743 3742339
SGTC_1098 clofazimine 15.1 µM 1.06909541018664 0.253977374811385 no 888 0.142513339811826 773 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2537 larixol 68.93 µM 1.06808621043841 0.254266096369512 no 889 0.142740812750441 788 6708759
SGTC_2735 sertaconazole 140 nM 1.06474107377493 0.255224334325276 no 890 0.143496558742604 693 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1927 st060202 13.8 µM 1.06387944115217 0.25547146051829 no 891 0.143691658752228 733 688887
SGTC_1299 1079-1439 3.74 µM 1.06110558915276 0.256267881629742 no 892 0.144320959061771 705 323161
SGTC_1182 1222-0449 220 µM 1.06106626715271 0.256279180955918 no 893 0.144329893327387 722 658318
SGTC_2656 pseudo-anisatin 100 µM 1.05927410196542 0.256794441957204 no 894 0.144737482950682 739 6708809 A neurotoxin.
SGTC_552 k242-0005 476 µM 1.05834814766417 0.257060871915245 no 895 0.144948374887568 734 4088318
SGTC_1571 st070080 73.4 µM 1.05690912422025 0.257475215257215 no 896 0.145276531939226 740 4315245
SGTC_180 1486-1293 102.781 µM 1.05650667911753 0.257591154814725 no 897 0.145368395493426 757 4140536
SGTC_926 2268-1401 59.4 µM 1.05628102135229 0.257656175943504 no 898 0.145419922033805 749 2931578
SGTC_1709 st033179 39.1045 µM 1.05540837339586 0.257907701286982 no 899 0.145619297472767 779 573381
SGTC_2567 aureobasidin a 60 nM 1.05517776201912 0.257974192213928 no 900 0.145672016354561 721 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1452 4194-0072 190 µM 1.05363295179113 0.258419828150614 no 901 0.146025498332262 819 1343545
SGTC_401 neomycin 50 µM 1.04837479574691 0.259939647365134 no 902 0.147232980597568 729 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3154 9100113 49.47 µM 1.04724723833189 0.260266156212361 no 903 0.147492781739788 730 25237525
SGTC_1170 0310-0127 64.8 µM 1.04375261912278 0.261279440216129 no 904 0.148299929023533 781 774975
SGTC_1912 st060209 90.8 µM 1.04313658821802 0.261458271649739 no 905 0.148442518581616 705 688787
SGTC_47 0149-0135 24.25 µM 1.04290184306489 0.261526433810898 no 906 0.148496877973142 720 5239155
SGTC_1071 trifluoperazine 6.31 µM 1.04167902153535 0.261881647861765 no 907 0.148780259175534 788 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2283 7944793 200 µM 1.04112934022695 0.262041403838706 no 908 0.148907762036703 749 2970533
SGTC_161 4065-0411 162.148 µM 1.03886837286303 0.262699042336895 no 909 0.149432978616877 794 1906281 YLR208W SEC13
SGTC_3259 9138485 49.47 µM 1.03857479038953 0.262784497388195 no 910 0.149501267624073 834 17646153
SGTC_1731 st035964 63 µM 1.03857007676499 0.262785869530973 no 911 0.149502364210679 734 6739575
SGTC_971 1315-0384 26.7 µM 1.03837229108708 0.26284344852458 no 912 0.149548382286717 729 6769120
SGTC_3079 9117512 49.47 µM 1.0382136525034 0.262889635752016 no 913 0.149585298981265 833 7185044
SGTC_2385 9074692 200 µM 1.03782309408292 0.263003363542568 no 914 0.149676211522409 758 17046906
SGTC_1144 3486-0183 12.5 µM 1.0374196605436 0.263120866873596 no 915 0.149770159779068 799 6744069
SGTC_454 lyso-paf C-16 6.67 µM 1.03736642477045 0.263136374232744 no 916 0.149782559821596 754 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3279 9140807 49.47 µM 1.03624959563971 0.263461809531698 no 917 0.150042857231483 772 45595718
SGTC_350 k064-0020 19.8 µM 1.03521369617884 0.263763846099568 no 918 0.150284561952846 816 2790705
SGTC_1216 1165-0504 9.65 µM 1.03505355843158 0.263810553117787 no 919 0.150321949774192 789 6304004
SGTC_351 caspofungin 25 nM 1.03498283808897 0.263831181304185 no 920 0.150338463029235 891 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2914 7968218 45.32 µM 1.03118142579612 0.264941211776952 no 921 0.151227874605943 738 2977111
SGTC_1396 3511-0007 98.6 µM 1.03064653289625 0.265097593303655 no 922 0.151353303145545 687 X1396
SGTC_1874 staurosporine 7.6 µM 1.02982737485554 0.265337173560992 no 923 0.151545523887839 804 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_702 1488-0190 94 µM 1.02950785420691 0.265430653981378 no 924 0.151620545457565 773 949357
SGTC_530 4358-1714 28 µM 1.02893918112306 0.265597068905437 no 925 0.151754127610567 816 1564641
SGTC_767 0929-0023 86 µM 1.02659468877685 0.266283713019656 no 926 0.152305678008201 865 1204563
SGTC_1711 st032263 62.8 µM 1.02458001594432 0.266874478029705 no 927 0.152780698936248 756 3958979
SGTC_1690 st023502 41.2 µM 1.02412248780972 0.267008731775668 no 928 0.152888711991613 758 24207482
SGTC_958 1222-0007 33 µM 1.02238672329943 0.267518371913812 no 929 0.153298950908491 828 7312461
SGTC_632 0781-2353 4.65 µM 1.02180480844314 0.267689338429252 no 930 0.153436646547101 797 6811515 YHR007C ERG11
SGTC_2170 morpholine 200 µM 1.02171473808051 0.267715806011376 no 931 0.153457966771439 790 121171 Reacts with secondary amines.
SGTC_126 0417-1624 672.48 µM 1.02136753919725 0.267817844306574 no 932 0.153540169301786 930 41912 YDL195W SEC31
SGTC_2902 5787006 60.46 µM 1.02113500075263 0.267886195994061 no 933 0.153595241221007 757 591003
SGTC_130 0136-0219 337.655 µM 1.02064057987498 0.268031553851968 no 934 0.153712378041856 794 234244
SGTC_1131 3454-3128 32.3 µM 1.02033161268404 0.26812240918702 no 935 0.153785607708705 828 710982
SGTC_2145 5634607 200 µM 1.01985153438776 0.268263612446592 no 936 0.153899438978883 715 308662
SGTC_2010 4012422 159 µM 1.01974241003336 0.268295713917328 no 937 0.153925321208876 784 952393
SGTC_2211 7117706 200 µM 1.01940485235175 0.26839502660457 no 938 0.154005401732716 750 822771
SGTC_3332 9141069 11.198 µM 1.01703321337085 0.26909330621477 no 939 0.15456881478615 717 17332883
SGTC_296 1222-0039 74.9 µM 1.01635728657654 0.269292485560325 no 940 0.154729638951828 730 5984176
SGTC_1119 parthenolide 318.541 nM 1.01545408893896 0.269558751505398 no 941 0.154944710484285 852 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1644 st010134 20.9 µM 1.01488504750946 0.269726574700952 no 942 0.155080313292337 753 3818134
SGTC_1743 st037606 46.3785 µM 1.01329058462135 0.270197096458468 no 943 0.155460691724659 770 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2808 7946468 45.46 µM 1.01318924751074 0.270227014637949 no 944 0.155484887706767 809 2970879
SGTC_833 3852-0053 558 µM 1.01244795231694 0.270445920691511 no 945 0.155661960273021 867 3123681
SGTC_946 3434-1334 87.4 µM 1.01083450090937 0.270922682472942 no 946 0.156047823656696 762 4047976
SGTC_157 1348-1695 65.819 µM 1.00972135576012 0.27125185212177 no 947 0.156314403947493 807 5380510
SGTC_2850 9015429 58.44 µM 1.00908212760426 0.271440969210918 no 948 0.156467624280602 736 6457570
SGTC_1825 st052143 62.6 µM 1.00767388154844 0.271857833599488 no 949 0.156805523824914 762 674173
SGTC_1251 0490-5699 265 µM 1.00713687931016 0.272016879091679 no 950 0.156934500416759 864 3883818
SGTC_1077 5-fluorocytosine 377 nM 1.00686173955876 0.272098385944068 no 951 0.15700061020497 777 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2152 5568786 200 µM 1.00676983408647 0.272125614543339 no 952 0.157022697068605 778 5399883
SGTC_2445 5742597 35.57 µM 1.00602545748366 0.272346198997475 no 953 0.157201662103274 747 1774255
SGTC_1878 temozolomide 1 mM 1.00543312943826 0.272521789662606 no 954 0.157344167001589 779 5394 DNA alkylating agent.
SGTC_1326 1431-2094 10.8 µM 1.00423912817229 0.272875912056288 no 955 0.157631683141857 790 616278
SGTC_500 h-89 112 µM 1.00182472114132 0.273592684619163 no 956 0.158214127668361 862 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2595 hexamethylquercetagetin 100 µM 0.998740326779255 0.274509711691142 no 957 0.158960249950032 744 386331
SGTC_2177 5811945 192 µM 0.997947051916243 0.274745806678872 no 958 0.159152517170729 790 5343475
SGTC_440 fluspirilene 35.1 µM 0.996973285404654 0.275035756519233 no 959 0.159388738600366 807 3396 An atypical antipsychotic.
SGTC_3330 9141424 71.43 µM 0.996715227976345 0.275112621254856 no 960 0.159451377994612 846 27261020
SGTC_2260 7964312 200 µM 0.996282324346773 0.275241589265137 no 961 0.159556494751215 755 231951
SGTC_3044 9093193 49.47 µM 0.995160964151388 0.27557579638939 no 962 0.159828991956313 805 25236277
SGTC_227 fluconazole 33.516 µM 0.990401190455924 0.276996603557773 no 963 0.160989031905677 835 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1057 3448-5381 134 µM 0.989654537717614 0.277219806662503 no 964 0.161171501596666 834 5497911
SGTC_1332 1480-0653 17.5 µM 0.989461498634953 0.277277527749399 no 965 0.161218699128536 814 5749438
SGTC_561 1550-0330 72.9 µM 0.989238361684098 0.277344255796597 no 966 0.161273266741464 771 6812934
SGTC_2203 7227154 166.4 µM 0.988805325941916 0.277473775483854 no 967 0.161379198980244 813 896304
SGTC_2354 9060492 162 µM 0.985836102840368 0.27836265666211 no 968 0.162106773172708 876 6471895
SGTC_2234 tolnaftate 200 µM 0.985439461967567 0.278481502013191 no 969 0.16220412697766 786 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_777 1315-0167 517 µM 0.985316108230847 0.278518467484343 no 970 0.162234411383256 768 4221767
SGTC_1265 0819-1001 68.8 µM 0.978918123758791 0.280439024492459 no 971 0.163810218200603 784 3106768
SGTC_2641 levomentholum 100 µM 0.978281408357384 0.280630504925375 no 972 0.16396758124037 792 16666
SGTC_1546 5-methoxyflavanone 78.7 µM 0.978272688721544 0.280633127634282 no 973 0.163969736962905 858 147795
SGTC_838 0109-0203 71.4 µM 0.978102249488428 0.28068439505713 no 974 0.164011877701423 834 759422
SGTC_2505 galangin 7.89 µM 0.976950190202229 0.281031048524633 no 975 0.164296906155098 746 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3144 9087057 49.47 µM 0.976367750152109 0.281206382834772 no 976 0.164441128526749 809 17249618
SGTC_580 1123-0028 41 µM 0.975904030050676 0.28134601615316 no 977 0.164556012417069 922 1677248 YPR107C YTH1
SGTC_1378 2093-0007 380 nM 0.97472077322744 0.28170246471373 no 978 0.164849392875267 805 3618014
SGTC_1777 st045864 34.765 µM 0.974548074115788 0.281754507419755 no 979 0.16489224075566 845 4691462
SGTC_496 calpeptin 138 µM 0.974490666620083 0.281771808137925 no 980 0.164906485561634 740 73364 A calpain inhibitor.
SGTC_56 0957-0365 83.25 µM 0.974042689285504 0.281906831256894 no 981 0.165017671767389 825 6752360
SGTC_1029 k015-0030 64.7 µM 0.970381160293838 0.28301160563375 no 982 0.165928267939575 804 2208316
SGTC_1547 harmine 94.2 µM 0.970314911117255 0.283031613785162 no 983 0.165944773492207 901 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.968539889096997 0.283567947193363 no 984 0.166387403765686 856 688798
SGTC_2778 tioconazole 65.09 nM 0.968192895333922 0.28367285028763 no 985 0.166474021236579 801 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_144 4161-2749 112.381 µM 0.967333241315271 0.283932820780916 no 986 0.166688735640461 752 797501 YMR168C CEP3
SGTC_2682 pyrogallin 40.03 µM 0.967215608660285 0.283968403283568 no 987 0.166718130453617 886 822798 An ATP competetive kinase inhibitor.
SGTC_3335 9143315 29.6265 µM 0.966693334342216 0.284126410920165 no 988 0.166848680148042 824 4899691
SGTC_1268 0828-0275 2.46 µM 0.963232094986209 0.285174627392586 no 989 0.167715530980169 882 745337
SGTC_443 clozapine 122 µM 0.960797662483756 0.285912983571112 no 990 0.168326957072401 764 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_61 0978-8327 98.565 µM 0.958997459843553 0.286459563560012 no 991 0.168780012424307 875 6150059 YHR072W ERG7
SGTC_1466 k213-0079 57.5 µM 0.957713232220396 0.286849785284922 no 992 0.16910369124232 859 3657981
SGTC_2287 7945887 168.79 µM 0.956503510788453 0.287217598025487 no 993 0.169408955748705 893 1245853
SGTC_3231 9132313 49.47 µM 0.955237841130791 0.287602660466966 no 994 0.169728716710158 854 4905967
SGTC_942 3253-1115 227 µM 0.954571637976062 0.287805441516742 no 995 0.16989718281907 852 46497897
SGTC_1622 st003707 19.4 µM 0.953546237768759 0.288117688023359 no 996 0.170156690291041 875 10140899
SGTC_1191 1487-1166 10.6 µM 0.952924663419826 0.288307042557818 no 997 0.170314121419845 934 3955771
SGTC_1423 4048-0112 5.59 µM 0.952473557272746 0.28844450291245 no 998 0.170428435110258 875 X1423
SGTC_2776 terbinafine 19.92 µM 0.951069240719462 0.288872621687617 no 999 0.170784613993462 822 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2290 7904846 200 µM 0.950217990589421 0.289132278593234 no 1000 0.171000749559666 829 2962154
SGTC_417 st075190 100 µM 0.95014405267134 0.289154837062527 no 1001 0.171019530926943 889 222757
SGTC_1955 wogonin 32.4 µM 0.94716242714203 0.290065220232763 no 1002 0.171778008973665 847 5281703 A flavanone.
SGTC_1986 st071812 45 µM 0.94465587905192 0.290831585352295 no 1003 0.172417294507231 823 11838594
SGTC_940 3232-1287 54.8 µM 0.942996584946573 0.291339426739613 no 1004 0.172841324855736 871 1585493 YIL048W NEO1
SGTC_119 0121-0043 24.815 µM 0.942879200803964 0.291375368844712 no 1005 0.172871347363484 1027 1092378
SGTC_83 0170-0301 39.027 µM 0.941298987874286 0.291859418940427 no 1006 0.173275830645973 802 3089716
SGTC_2715 st079500 56.4 µM 0.940092733906954 0.292229170011812 no 1007 0.173584997790081 815 28246688
SGTC_2961 9083290 32.55 µM 0.939818514295332 0.292313256495829 no 1008 0.173655330182474 819 17741490
SGTC_2736 butenafine 14.65 µM 0.939578640464597 0.2923868204424 no 1009 0.17371686836512 887 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_212 3807-4682 38.772 µM 0.939054682438836 0.292547536595651 no 1010 0.1738513348719 1010 3125501 YBL034C STU1
SGTC_2568 diosmetin 100 µM 0.937953082698494 0.292885569373919 no 1011 0.174134260878781 889 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2980 9014342 25.29 µM 0.937368197459259 0.293065118721538 no 1012 0.174284596968051 800 2996599
SGTC_1275 0867-0008 21.1 µM 0.936320662689967 0.293386820776277 no 1013 0.174554056322879 870 3422836
SGTC_1663 st014140 55.4 µM 0.936214408468142 0.293419461004245 no 1014 0.17458140306926 1015 4207120
SGTC_2845 9003024 42.97 µM 0.936122120896067 0.293447812182998 no 1015 0.174605157413811 886 2990173
SGTC_483 fpl-64176 144 µM 0.935809255229864 0.293543935437584 no 1016 0.174685702692833 818 3423
SGTC_1789 tunicamycin 25 nM 0.933966673357587 0.294110336483695 no 1017 0.175160542146484 868 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_819 1013-0258 27.7 µM 0.933220826014302 0.294339749981967 no 1018 0.175352982020986 861 5753198
SGTC_2324 6149169 200 µM 0.931682724438292 0.294813111895102 no 1019 0.17575025851211 840 2888231
SGTC_881 0833-0569 170 µM 0.929300801603222 0.295546857652384 no 1020 0.176366609957407 840 5418700
SGTC_563 tetrahydrosecaminediol 614 µM 0.927567789026838 0.296081235258785 no 1021 0.17681590638988 920 334274 A psychoactive constituent of the cannabis plant.
SGTC_2090 5301565 104.445 µM 0.923642519841247 0.297293235770414 no 1022 0.177836234094839 901 2056344
SGTC_2889 9059656 51.95 µM 0.923469394117652 0.297346743746889 no 1023 0.177881321444883 926 3949838
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.920205761198089 0.298356257072312 no 1024 0.178732622120677 952 16486 A toxic proline analog.
SGTC_593 1203-0218 61.7 µM 0.919519864083491 0.298568618342006 no 1025 0.178911860259204 932 3666956
SGTC_2222 6885208 172.143 µM 0.919254672331571 0.298650743042088 no 1026 0.178981190289389 870 609514
SGTC_139 0099-0334 718.624 µM 0.918998465827211 0.2987300949405 no 1027 0.179048187327985 1017 97690
SGTC_368 fentichlor 4.58 µM 0.918619616348165 0.298847449199466 no 1028 0.17914728395575 802 7329 A pesticide.
SGTC_3014 9081533 49.47 µM 0.917734290813167 0.299121773586079 no 1029 0.179378995305787 907 21367265
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.9173302666405 0.299247001309715 no 1030 0.179484800904294 925 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_425 3825-7017 13.1 µM 0.915025697275956 0.29996175939177 no 1031 0.180089069923767 917 3397440
SGTC_2292 7671323 168.05 µM 0.914271933655503 0.300195705390785 no 1032 0.180286987181525 873 937504
SGTC_2730 imipramine 71.33 µM 0.911831996815208 0.300953554934512 no 1033 0.180928581956484 995 3696 A tricyclic antidepressant.
SGTC_615 k087-0205 167 µM 0.911614406567034 0.301021180801313 no 1034 0.180985867916443 849 9642773
SGTC_1681 tripelennamine 100 µM 0.911349447281042 0.301103537955448 no 1035 0.181055640279817 856 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2903 5923464 63.88 µM 0.909886126298481 0.301558564014908 no 1036 0.18144128358097 890 2876576
SGTC_2006 4011487 200 µM 0.907715586964695 0.302234071821093 no 1037 0.182014253312454 932 45595294
SGTC_2394 5221648 200 µM 0.907464144365255 0.302312368793812 no 1038 0.182080701101678 991 788586
SGTC_3173 9105693 49.47 µM 0.905344800933877 0.302972674607764 no 1039 0.182641374476782 934 17096658
SGTC_1724 st037281 8.293 µM 0.904051965184175 0.303375789134539 no 1040 0.182983923647764 875 574124 YDL195W SEC31
SGTC_988 1497-1057 103 µM 0.903730139590427 0.3034761736756 no 1041 0.183069256687328 930 3533044
SGTC_1671 st016596 74.5 µM 0.903311706859801 0.303606714307346 no 1042 0.183180242521586 951 2829167
SGTC_2614 arthonioic acid 13.39 µM 0.900888952588168 0.304363045818762 no 1043 0.183823682802743 867 6710684
SGTC_3198 9112019 49.47 µM 0.900323286108876 0.30453975538411 no 1044 0.183974116196299 899 45595555
SGTC_1843 st055809 45.5 µM 0.900245247889767 0.304564137465819 no 1045 0.183994875702695 850 16413835
SGTC_1117 retinoic acid 1.10837 µM 0.900128208442819 0.304600706629251 no 1046 0.184026012939419 964 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_772 k072-0172 35.3 µM 0.899437273503436 0.304816630148061 no 1047 0.184209896482201 843 5861980
SGTC_396 dithiazanine 1.25 µM 0.897406581722465 0.305451633393468 no 1048 0.184751000887743 869 10578 An antihelmenthic.
SGTC_1437 4092-1038 11.6 µM 0.895842498296875 0.305941126318987 no 1049 0.185168444270441 960 3977136
SGTC_2082 5219693 150 µM 0.895804586064579 0.305952995575993 no 1050 0.185178570057754 919 2834649
SGTC_2807 7945238 51.95 µM 0.891119618255854 0.307421292937841 no 1051 0.186432500613947 908 17148797
SGTC_2420 aureobasidin a 50 nM 0.890877145141996 0.30749736982172 no 1052 0.186497541314855 952 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2465 5809242 33.21 µM 0.889516723986697 0.307924360758562 no 1053 0.186862719627995 944 2731748
SGTC_2618 avocadyne 43.43 µM 0.888803723965603 0.308148251701682 no 1054 0.187054287076937 921 3015189
SGTC_619 1652-1634 108 µM 0.887619374295166 0.308520310134635 no 1055 0.187372764210429 864 5400454
SGTC_256 clotrimazole 625 nM 0.885336709983829 0.309237954145446 no 1056 0.187987528151227 911 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_681 1642-0006 26.6 µM 0.885318834271984 0.309243576946221 no 1057 0.187992347321381 937 4446530
SGTC_749 1000-0129 128 µM 0.884920407622086 0.309368913544395 no 1058 0.188099780225982 990 708470
SGTC_2033 5192550 145 µM 0.883859441705732 0.309702779135527 no 1059 0.188386046870846 909 182073
SGTC_1052 3253-3998 198 µM 0.883827280067722 0.309712902239135 no 1060 0.188394728822077 984 5450317
SGTC_3302 9125395 16.351 µM 0.883077957118474 0.309948797791289 no 1061 0.188597076472842 899 17599668
SGTC_851 0394-0702 453 µM 0.881909320129294 0.310316854450267 no 1062 0.18891292328528 987 762646
SGTC_743 1275-0778 158 µM 0.881399871252868 0.310477362455494 no 1063 0.189050713667135 967 2849257 YMR203W TOM40
SGTC_1037 k284-1091 78.7 µM 0.879361026876617 0.311120085966171 no 1064 0.189602778231787 880 3334711
SGTC_1431 4049-0260 9.09 µM 0.879333416361725 0.311128793840691 no 1065 0.189610261221252 937 3854841
SGTC_3214 9129694 49.47 µM 0.878119540063221 0.311511733679619 no 1066 0.189939424992442 893 17158655
SGTC_1306 1185-0270 9.02 µM 0.876431852114439 0.312044485124238 no 1067 0.190397654382131 978 1548076
SGTC_992 3909-8734 162 µM 0.87591245007345 0.31220852367041 no 1068 0.1905388153526 917 4288319
SGTC_711 k292-0785 179 µM 0.875670761522306 0.312284866907482 no 1069 0.190604522382277 989 4146315
SGTC_643 k048-0106 28.4 µM 0.875596023004244 0.312308476527139 no 1070 0.19062484409982 926 6763920
SGTC_1756 st041558 35.5 µM 0.874706799196471 0.312589438127009 no 1071 0.190866729828478 1023 3955792
SGTC_1621 st003705 32.4 µM 0.874074154144712 0.31278939674096 no 1072 0.19103893586302 996 24207032
SGTC_2954 9074818 52.69 µM 0.873983286908131 0.312818121458673 no 1073 0.191063677755706 910 16648742
SGTC_1175 0741-0056 27.6 µM 0.872103444251077 0.313412627270429 no 1074 0.191575973678332 1012 765927
SGTC_1461 k072-0203 53.8 µM 0.871971747522798 0.31345429495178 no 1075 0.191611895266214 897 5418714
SGTC_1960 st011366 51.8 µM 0.871727134985786 0.313531694515042 no 1076 0.191678626707082 988 3972846
SGTC_2276 7947513 42.08 µM 0.871713204834342 0.313536102498801 no 1077 0.191682427345658 895 2105100
SGTC_172 1112-0046 2.638 µM 0.869958641280566 0.314091520070804 no 1078 0.192161503346766 855 2802135 YIL048W NEO1
SGTC_75 0159-0059 199.013 µM 0.869634903563498 0.314194047258843 no 1079 0.192249978514832 926 5377270
SGTC_2733 amorolfine 100 µM 0.869566172819291 0.314215816014981 no 1080 0.192268765334299 926 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1462 k081-0014 26.5 µM 0.868843729376859 0.314444671117871 no 1081 0.192466305507945 770 3270634
SGTC_2764 methyldopa 94.69 µM 0.868488804038491 0.314557130240211 no 1082 0.192563399390998 962 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_313 3474-0040 5.03 µM 0.867035980973906 0.3150176407245 no 1083 0.192961147750922 936 1043375 YIL048W NEO1
SGTC_2556 citropten 84.59 µM 0.865174500839032 0.315608106240984 no 1084 0.193471509358145 1014 2775 A potential DNA crosslinker.
SGTC_373 0844-0104 25.9 µM 0.864047673713349 0.315965767220146 no 1085 0.193780851028778 999 5375804
SGTC_1013 4112-3890 241 µM 0.863441579632995 0.316158216035846 no 1086 0.19394736334783 903 705171
SGTC_1611 st001856 99.4 µM 0.861992351172475 0.316618581313294 no 1087 0.194345863452476 914 647478
SGTC_2762 leflunomide 42.06 µM 0.860574147186159 0.317069366465996 no 1088 0.194736314881168 968 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2242 6630449 61.2675 µM 0.858988459285882 0.317573709075388 no 1089 0.1951734415851 861 691249 YDR170C SEC7
SGTC_2472 5377652 49.4 µM 0.856499162522252 0.318366135912754 no 1090 0.195860867938389 953 1610903
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.853725869378281 0.319249947927408 no 1091 0.196628448489758 869 61125 An anti-inflammatory.
SGTC_557 1315-0110 16.2 µM 0.852085417883648 0.319773222554979 no 1092 0.197083342388555 1026 6833801
SGTC_1273 0849-0096 14.1 µM 0.849292999179911 0.320664779146752 no 1093 0.197859137714696 946 5286025
SGTC_1026 k007-1105 30.6 µM 0.847605563323326 0.321204041860239 no 1094 0.198328837508126 980 7066794
SGTC_1870 st057514 26.5 µM 0.847539396023894 0.321225194983484 no 1095 0.198347268955224 954 5393161
SGTC_1606 st000094 49.2 µM 0.846425612654888 0.321581349066605 no 1096 0.198657677622283 1040 1242210
SGTC_412 gemfibrozil 100 µM 0.845322299629983 0.321934316811759 no 1097 0.198965456886256 949 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1218 1348-1416 30.7 µM 0.845030387527692 0.322027731130334 no 1098 0.199046936485861 1001 6787668
SGTC_17 0960-0276 49.807 µM 0.844955987997222 0.322051541402059 no 1099 0.199067706376114 1036 6821114
SGTC_1231 0242-0792 125 µM 0.843292925736747 0.322583965962648 no 1100 0.199532319144025 967 3707635
SGTC_2720 fluspirilene 36.88 µM 0.842890653241747 0.322712807050548 no 1101 0.199644800703151 918 3396 An atypical antipsychotic.
SGTC_1415 3966-0071 78.1 µM 0.842143115741487 0.322952287213949 no 1102 0.1998539249549 977 2893185
SGTC_2865 9030313 51.95 µM 0.841212190867054 0.323250619768696 no 1103 0.200114536092178 890 42562754
SGTC_1224 0823-0416 294 µM 0.83957362938995 0.323776004022565 no 1104 0.200573745026012 1003 3598164
SGTC_3310 9130229 44.1445 µM 0.83944513901071 0.323817217725814 no 1105 0.200609781352375 961 7761258
SGTC_1853 st056710 91.2 µM 0.83879282435819 0.324026483067415 no 1106 0.200792789041721 1049 269167
SGTC_2663 amphotericin b 100 µM 0.838746985901922 0.324041190333342 no 1107 0.200805652844553 984 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1152 3909-8331 15.9 µM 0.838669008264827 0.324066210084486 no 1108 0.200827537111977 950 16001939
SGTC_2727 riluzole 51.77 µM 0.837686496806123 0.324381524833686 no 1109 0.201103399594242 969 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_985 1493-0307 8.71 µM 0.837493068162874 0.324443616213226 no 1110 0.201157735856658 963 3278274
SGTC_3188 9110789 49.47 µM 0.836320065992364 0.324820259167516 no 1111 0.201487433778756 991 849217
SGTC_914 3820-6779 408 µM 0.835828227119812 0.324978238589863 no 1112 0.201625772149032 1018 2893481
SGTC_1907 st060210 83.7 µM 0.835210794739553 0.325176603401483 no 1113 0.201799516434113 1053 688793
SGTC_1066 ketoconazole 628 nM 0.834397453431527 0.325437984236959 no 1114 0.202028525898102 1034 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_665 3914-0008 307 µM 0.834286770502443 0.325473560689231 no 1115 0.202059702494745 985 1069549
SGTC_2304 7443016 91.4 µM 0.830899028684285 0.326563239364635 no 1116 0.203015336213194 924 939854
SGTC_789 1309-1135 70.6 µM 0.830869000787334 0.326572904576908 no 1117 0.203023818704492 1032 3092424
SGTC_3180 9109287 49.47 µM 0.830725638706273 0.326619050769862 no 1118 0.203064319549517 944 18891271
SGTC_198 3454-2873 16.191 µM 0.829043062342218 0.327160846034144 no 1119 0.203540020242497 991 710957
SGTC_332 4112-0506 40.9 µM 0.828989451156631 0.327178115013105 no 1120 0.203555188201193 989 2790355
SGTC_1025 k007-0731 70 µM 0.823601271253287 0.328915611580491 no 1121 0.20508307670396 1002 6256118
SGTC_1624 st003710 6.25 µM 0.820843053092767 0.329806474664258 no 1122 0.205867835871942 1061 24207033
SGTC_1317 1273-0028 910 nM 0.820048115447445 0.330063407205526 no 1123 0.206094339204442 1018 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_263 alizarin 107.927 µM 0.817128247897777 0.33100782763198 no 1124 0.20692757075762 1057 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1428 4049-0204 61.7 µM 0.816968579560234 0.331059502859459 no 1125 0.206973192124774 1050 X1428
SGTC_655 k060-0012 42 µM 0.815841793730965 0.331424268445869 no 1126 0.207295313106492 988 5994525
SGTC_2186 6124449 200 µM 0.814587638719054 0.331830454373618 no 1127 0.207654194249449 1005 3834182 YLR033W RSC58
SGTC_2661 dactinomycin 12.96 µM 0.813873636892069 0.332061788081778 no 1128 0.207858672418097 1047 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1943 st076331 65.2 µM 0.813524407567087 0.332174960293532 no 1129 0.207958729136951 1104 24208415
SGTC_476 mead acid 10 µM 0.811991757831271 0.332671815855841 no 1130 0.208398180458818 1014 5312531 An omega 9 fatty acid.
SGTC_2159 5658611 73.75 µM 0.810939378980034 0.333013147172037 no 1131 0.208700242285308 1054 793844
SGTC_896 0964-0007 44.5 µM 0.809896711045033 0.333351465322463 no 1132 0.208999771146304 1065 6756758
SGTC_3126 9127922 49.47 µM 0.809743809570375 0.333401089212837 no 1133 0.209043716671226 1030 45595682
SGTC_2673 kobusone 100 µM 0.809738841288719 0.333402701708362 no 1134 0.209045144699977 1053 6710676 An epoxy ketone and protein crosslinker.
SGTC_23 0213-0011 39.996 µM 0.807860753372275 0.334012470460082 no 1135 0.209585373272487 1013 627608
SGTC_929 2805-0021 398 µM 0.806391132722853 0.334489925879489 no 1136 0.210008679083921 1000 3098024
SGTC_2134 5324836 1.464 µM 0.805137555689243 0.334897404005149 no 1137 0.210370152942473 965 699272
SGTC_2156 5649887 115 µM 0.804706029941523 0.335037717465158 no 1138 0.210494669549502 1098 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1139 k015-0024 46.9 µM 0.804524939452319 0.335096607099383 no 1139 0.210546936030865 1059 2766652
SGTC_1202 1988-0068 29.6 µM 0.802895366363771 0.335626717556355 no 1140 0.211017607236626 1013 2850480
SGTC_1529 apigenin 74 µM 0.802598914168587 0.335723190554451 no 1141 0.211103298078298 1051 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1305 1181-0477 144 µM 0.801659976855904 0.336028815795908 no 1142 0.211374836690507 1037 6252086
SGTC_3324 9138759 60.749 µM 0.799764575723432 0.336646101411487 no 1143 0.211923605429821 1039 45595710
SGTC_3066 9117245 49.47 µM 0.799681567694523 0.336673145166539 no 1144 0.211947657481647 1077 17176980
SGTC_2157 5649910 96.377 µM 0.79928567190154 0.336802138391145 no 1145 0.212062392520821 1019 2858091
SGTC_2711 st079103 59.1 µM 0.799269382778675 0.336807446225605 no 1146 0.212067114069048 1031 54693780
SGTC_1290 0986-0249 10.2 µM 0.799187041182549 0.3368342778523 no 1147 0.212090982459302 1038 53329
SGTC_2789 5281112 71.43 µM 0.798620000043434 0.337019075004747 no 1148 0.212255393543286 1016 765948
SGTC_1393 3470-5649 58.2 µM 0.798332208988802 0.337112880373975 no 1149 0.212338865784237 944 4108395
SGTC_2653 dihydrofissinolide 100 µM 0.798006378456448 0.337219096920228 no 1150 0.212433394320624 1063 6857746
SGTC_684 1140-0066 328 µM 0.796329283999912 0.337766013186096 no 1151 0.212920334477049 1089 6813534
SGTC_1285 0929-0069 65.5 µM 0.796183562660334 0.337813550484962 no 1152 0.212962675036781 1025 1206237
SGTC_830 4076-0286 57.8 µM 0.796000541459342 0.337873259431248 no 1153 0.213015860344481 1129 6866659
SGTC_452 diindolylmethane 8 µM 0.795403099279129 0.338068197715802 no 1154 0.213189528838893 948 3071 Inhibits expression of several cancer promoting factors.
SGTC_1926 methyl fluorone black 53.6 µM 0.794480613741332 0.338369279068219 no 1155 0.213457845237167 944 72721 Reacts with homocysteine.
SGTC_2820 7989630 71.43 µM 0.794226486094351 0.3384522395617 no 1156 0.213531795990238 949 2984098
SGTC_1807 st050092 58.9 µM 0.789532687082786 0.339985946167106 no 1157 0.214900366488251 1030 5008496
SGTC_732 3970-1727 52.7 µM 0.788368950477232 0.34036661028348 no 1158 0.215240463554917 1056 1275699
SGTC_1331 1472-0049 76.2 µM 0.787619400543139 0.340611878028703 no 1159 0.21545968162455 1040 24051409
SGTC_1936 st074407 74.3 µM 0.787555158417276 0.340632902476383 no 1160 0.215478476302969 1117 809813
SGTC_2097 5376186 200 µM 0.787448934429095 0.340667667366777 no 1161 0.215509555282482 1041 742755
SGTC_2867 9039098 71.43 µM 0.785521741776021 0.341298632011846 no 1162 0.216073863988756 1040 6463460
SGTC_3204 9114183 49.47 µM 0.783956814378342 0.341811317383651 no 1163 0.216532725419627 1020 17027248
SGTC_2413 inermin 26.06 µM 0.782678887766223 0.342230195076419 no 1164 0.216907851514287 1072 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1298 1079-1278 263 µM 0.778827019349704 0.343493930243671 no 1165 0.218040809582408 1102 2840950
SGTC_1155 4088-0394 48.2 µM 0.778141821961788 0.343718916222275 no 1166 0.218242704916848 1052 2326248
SGTC_3314 9135860 59.4275 µM 0.776929377950123 0.344117160337733 no 1167 0.218600218760102 1091 25252478
SGTC_278 4092-0821 23.9 µM 0.776380685024475 0.344297443040971 no 1168 0.218762122813031 1067 877900
SGTC_2519 cryptotanshinone 88.04 µM 0.775262332492859 0.344665006947926 no 1169 0.219092331178852 1068 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_747 3448-8087 38.7 µM 0.773736123452716 0.34516685587223 no 1170 0.219543426688002 1085 5168703
SGTC_1433 4060-0023 7.6 µM 0.773702383511499 0.345177953339685 no 1171 0.219553405091027 1081 3840627
SGTC_1297 1068-0111 14.1 µM 0.773115908134105 0.345370873320494 no 1172 0.219726893587173 1055 767057
SGTC_737 1950-0117 57.9 µM 0.770567546162481 0.346209618285439 no 1173 0.220481651912575 1077 5393513
SGTC_616 4092-0450 108 µM 0.769220762165194 0.346653191845233 no 1174 0.220881133524689 1107 787165
SGTC_1101 ebselen 5.29 µM 0.769144611395698 0.346678278968432 no 1175 0.220903733654457 1161 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1877 wortmannin 25 µM 0.765795452584104 0.347782290108741 no 1176 0.221899010208181 1113 312145 A covalent inhibitor of PI 3-kinase.
SGTC_101 0490-5701 117.494 µM 0.765404843487473 0.34791113414308 no 1177 0.222015254853062 1022 4661669
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.765089318641461 0.34801522414958 no 1178 0.222109179924087 1135 4174840
SGTC_2301 7769476 200 µM 0.764684687947722 0.348148726472629 no 1179 0.222229663107186 1067 977820
SGTC_1525 8-methoxypsoralen 92.5 µM 0.764582819381631 0.348182339568776 no 1180 0.222260001454269 1134 4114 Related to psoralen; DNA damaging agent.
SGTC_657 3534-0529 86.7 µM 0.764431013631738 0.348232432417662 no 1181 0.222305216404796 1104 1049549
SGTC_2425 5628681 7.85 µM 0.763858192030036 0.348421475881916 no 1182 0.222475877092282 1127 5714958
SGTC_3099 9120367 49.47 µM 0.763321731271475 0.348598553634237 no 1183 0.222635772526111 1102 24824940
SGTC_1204 4049-0315 18.3 µM 0.762204644955572 0.348967393131915 no 1184 0.222968937130498 1047 588402
SGTC_2932 9016711 44.54 µM 0.761398174348847 0.349233762303192 no 1185 0.223209638783676 1107 7117328
SGTC_1587 estradiol valerate 56.1 µM 0.76093885438313 0.34938550430269 no 1186 0.223346794894168 1103 13791 A steroid.
SGTC_2718 lomofungin 53.02 µM 0.760865290675274 0.349409809215575 no 1187 0.223368765979571 1094 5351222 A RNA synthesis inhibitor.
SGTC_1588 farnesol 29.9 µM 0.759365542291662 0.349905449637742 no 1188 0.223816960050566 1073 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2000 st075254 36.4 µM 0.758752444907568 0.350108141249758 no 1189 0.224000328950493 1054 17234175
SGTC_348 k064-0012 10.7 µM 0.758592204638313 0.35016112414772 no 1190 0.224048268651388 1063 5066323
SGTC_3304 9125678 46.087 µM 0.758366183358387 0.350235862270468 no 1191 0.224115898218844 1056 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_697 0508-1955 564 µM 0.758300362419303 0.350257628273787 no 1192 0.224135595188537 1113 6243113
SGTC_1620 st003704 16.5 µM 0.75663225951474 0.350809409040735 no 1193 0.224635104423159 1096 2834414
SGTC_1579 chlormadinone acetate 49.4 µM 0.755945740838214 0.351036589541967 no 1194 0.224840863995531 1128 45114258 A steroidal progestin.
SGTC_1150 3909-7983 10.9 µM 0.755852164128881 0.351067559764564 no 1195 0.224868918560819 1098 23965914
SGTC_1320 1313-0481 95.3 µM 0.755372820658003 0.351226219172093 no 1196 0.22501265822015 1141 6813365 YLR208W SEC13
SGTC_775 4577-0580 57.3 µM 0.754765449000605 0.351427292277969 no 1197 0.225194864171907 1129 2006902
SGTC_510 ag-490 170 µM 0.753816930117571 0.351741386863727 no 1198 0.225479578280428 1203 5328779
SGTC_413 propylparaben 100 µM 0.753136706481785 0.351966699923267 no 1199 0.225683884392979 1084 7175 A pharmaceutical preservative.
SGTC_2028 5153890 36.43 µM 0.752658681316629 0.352125069125206 no 1200 0.22582752255475 1114 2830968 YPR165W RHO1
SGTC_2224 6650123 117.647 µM 0.752478049509455 0.35218491891968 no 1201 0.225881812695411 1078 2908370
SGTC_1788 fluconazole 20 µM 0.752110641290391 0.352306665732412 no 1202 0.225992262550373 1046 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_553 k007-0256 45.7 µM 0.748880294994993 0.353377744938993 no 1203 0.226964679016423 1143 6287000
SGTC_2189 6047310 154.431 µM 0.748821545482346 0.35339723517889 no 1204 0.226982385935544 1085 711535
SGTC_1987 st072290 61.9 µM 0.748496911374218 0.353504939966711 no 1205 0.227080243683403 1109 54697379
SGTC_290 2043-6722 48.1 µM 0.74842705953693 0.353528116444723 no 1206 0.22710130293951 1119 773758 YLR208W SEC13
SGTC_2584 androsterone 48.74 µM 0.74767047189554 0.353779183086513 no 1207 0.22732947302869 1204 2754130 A steroid.
SGTC_276 colchicine 750 µM 0.747612777007742 0.353798331215294 no 1208 0.227346877828814 1159 2833 A microtubule depolymerizer.
SGTC_1221 2958-7315 257 µM 0.747094418067744 0.353970383903464 no 1209 0.227503284690313 1105 4562705
SGTC_44 0929-0055 61.211 µM 0.746275480568395 0.354242264806023 no 1210 0.227750509977607 1082 1379590
SGTC_464 bw-b 70c 158 µM 0.746035596807976 0.354321918432981 no 1211 0.227822956009444 1144 5353454
SGTC_2181 6316240 54.2555 µM 0.741867630724712 0.355706910086396 no 1212 0.229083769712712 1105 12779990
SGTC_1801 st050089 28.441 µM 0.73962382868578 0.356453303762028 no 1213 0.229764139393654 1171 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1490 4089-0339 670 nM 0.739227435995846 0.356585219802537 no 1214 0.229884451793508 1096 742542
SGTC_2508 celastrol 40.54 µM 0.736958933616718 0.357340487302061 no 1215 0.230573661606184 1099 122724 Celastrol is a natural product and antioxidant.
SGTC_1388 3346-4487 254 µM 0.735811674771974 0.357722664882797 no 1216 0.23092265763603 1173 3345614
SGTC_1666 st014829 29 µM 0.734125331626302 0.358284682422503 no 1217 0.231436178010545 1169 3858230
SGTC_1146 3579-1023 7 µM 0.733500364685564 0.358493046924604 no 1218 0.231626652746239 1166 X1146
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.732064539322204 0.358971911817113 no 1219 0.232064588183059 1164 551469
SGTC_309 k408-0051 1.48 µM 0.732057204461924 0.358974358650345 no 1220 0.232066826542645 1139 3640463
SGTC_58 0957-0393 9 µM 0.727350098181307 0.360545789712381 no 1221 0.233505757816667 1146 6997992
SGTC_2935 9038016 29.96 µM 0.726240715565829 0.360916492889255 no 1222 0.233845607903119 1156 6463195
SGTC_2053 5265679 138 µM 0.72608031447503 0.360970102166456 no 1223 0.233894768106184 1145 764595
SGTC_1136 pergolide 1.05886 µM 0.72111167216952 0.362632070528718 no 1224 0.235420405095543 1113 47811 A dopamine receptor agonist.
SGTC_264 promethazine 12.5 mM 0.720514516547337 0.362831989038811 no 1225 0.23560413255377 1222 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1364 1653-0028 37.6 µM 0.720258234841706 0.362917799679561 no 1226 0.235683007248648 1122 5718652
SGTC_2905 7799065 20.05 µM 0.718710575275489 0.363436147707686 no 1227 0.236159633014784 1115 1296806
SGTC_1774 st048371 48.465 µM 0.716008688463073 0.364341672979491 no 1228 0.236992992018171 1155 4242727
SGTC_2221 6807166 181.081 µM 0.716008466657906 0.364341747347671 no 1229 0.236993060497141 1126 674925
SGTC_843 0310-0051 143 µM 0.715393763047966 0.364547868508173 no 1230 0.237182882656943 1190 2065037
SGTC_1014 4130-3005 69.3 µM 0.714536431567914 0.364835412551039 no 1231 0.237447768391235 1199 743608
SGTC_460 trequinsin 123 µM 0.713927109217386 0.365039821997788 no 1232 0.237636126575794 1207 5537 A vasodilator.
SGTC_2429 5902844 64.44 µM 0.713240833465149 0.365270092940863 no 1233 0.237848371292542 1189 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_252 miconazole 1.30953 nM 0.709411537580685 0.3665558533119 no 1234 0.239034565026516 1130 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_648 0375-0473 33.3 µM 0.709411230718239 0.366555956407177 no 1235 0.239034660212128 1167 1713139
SGTC_1905 st060207 84.5 µM 0.709369747817267 0.366569893330396 no 1236 0.239047527977184 1129 1948547
SGTC_1503 4585-0012 61.3 µM 0.707957584835311 0.367044439593997 no 1237 0.23948579885738 1168 2922052
SGTC_2684 capsaicin 100 µM 0.705791176978572 0.367772838709771 no 1238 0.240159004862883 1181 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_577 r071-0003 38.6 µM 0.705418410874954 0.36789821981046 no 1239 0.240274944948711 1224 4568517 YMR134W ERG29
SGTC_3020 9089140 49.47 µM 0.70517321804119 0.367980698899301 no 1240 0.24035122300889 1197 17217859
SGTC_894 0960-0238 55.9 µM 0.705109637224489 0.36800208749972 no 1241 0.240371004783724 1171 6741907 YDL195W SEC31
SGTC_3110 9122132 49.47 µM 0.70430487342609 0.368272845565121 no 1242 0.240621466007086 1236 918317
SGTC_380 3970-0968 6 µM 0.6987725109987 0.370135941120052 no 1243 0.2423471051115 1162 2891601
SGTC_447 ml7 120 µM 0.698434322293981 0.3702499300004 no 1244 0.242452809048082 1223 4216 Selective myosin light chain kinase inhibitor.
SGTC_69 0096-0274 206.684 µM 0.698130683255987 0.370352283382176 no 1245 0.242547735448499 1320 6741392
SGTC_792 4534-1957 155 µM 0.697245070032523 0.370650866273283 no 1246 0.242824718848429 1158 1717904
SGTC_2691 st077356 60.2 µM 0.696263381156373 0.370981931954914 no 1247 0.243131950691618 1231 2839272
SGTC_2072 5231554 129 µM 0.695029301386609 0.371398249672207 no 1248 0.243518469435614 1263 789545
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.694398171139657 0.371611220121449 no 1249 0.243716270168689 1252 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1291 0993-0025 5.79 µM 0.694237872190359 0.371665318132536 no 1250 0.24376652281526 1206 4353356
SGTC_1460 k062-0059 9.15 µM 0.689293966577447 0.373335037005622 no 1251 0.245319146998531 1184 1373085
SGTC_1562 morin hydrate 59.1 µM 0.688932114903494 0.373457340065561 no 1252 0.245432994228293 1228 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_826 1683-5028 118 µM 0.688829944986528 0.373491875013594 no 1253 0.245465144477748 1218 722377
SGTC_2277 7947813 106.88 µM 0.688537732897575 0.373590652643466 no 1254 0.245557108608746 1254 1246798
SGTC_2576 guaiol 23.12 µM 0.68815221288745 0.373720984231427 no 1255 0.245678466645914 1211 227829
SGTC_2799 7812892 81.82 µM 0.687848294380048 0.373823739226214 no 1256 0.245774160003562 1201 20205235
SGTC_949 1165-0505 146 µM 0.686892922565287 0.374146809277117 no 1257 0.246075103602899 1234 6244267
SGTC_1683 st010134 710 nM 0.686050636550701 0.374431711395853 no 1258 0.246340588867995 1226 3818134
SGTC_430 0958-0115 16.4 µM 0.685162516685187 0.37473219102667 no 1259 0.246620686990136 1173 6833180
SGTC_2107 5363541 170.161 µM 0.684032065852939 0.375114769068903 no 1260 0.246977458843623 1198 244052
SGTC_1020 4335-0961 93.3 µM 0.68341743435687 0.375322830170428 no 1261 0.247171553233461 1147 669075
SGTC_2731 amoxapine 43.43 µM 0.681894443942379 0.375838539280748 no 1262 0.247652849446749 1254 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3294 9122953 26.2835 µM 0.681409388448429 0.376002833517648 no 1263 0.24780624196256 1217 16459826
SGTC_1765 st044815 90.4 µM 0.679807584040265 0.376545543818015 no 1264 0.248313151966862 1203 645695
SGTC_2628 lathosterol 100 µM 0.678413997979349 0.377017905902747 no 1265 0.248754618093524 1283 6710616
SGTC_1661 st013063 9.66 µM 0.676340339903879 0.37772112200324 no 1266 0.249412293146034 1252 721395
SGTC_1973 st070275 50.2 µM 0.676090795356357 0.377805774589031 no 1267 0.249491500184538 1166 17118334
SGTC_1240 0356-0016 42.1 µM 0.672933042995675 0.37887747944496 no 1268 0.250494944675256 1208 4305613
SGTC_3023 9089636 49.47 µM 0.672309025681585 0.379089374283253 no 1269 0.250693492508559 1308 17249241
SGTC_2983 9022671 12.99 µM 0.671880226823505 0.37923500070938 no 1270 0.25082997465571 1232 6405161
SGTC_3041 9091929 49.47 µM 0.671401294928538 0.379397673316281 no 1271 0.250982460110233 1293 25236887
SGTC_906 1165-0455 526 µM 0.668892201641884 0.380250252963195 no 1272 0.251782122572648 1227 3252859
SGTC_690 glyoxal 20.3 µM 0.668002668864809 0.380552652559198 no 1273 0.252065944440929 1154 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_334 1502-1024 68.5 µM 0.666556123592971 0.38104456619658 no 1274 0.252527851612493 1267 3296216
SGTC_286 k060-0067 22.9 µM 0.666152328097071 0.381181915664388 no 1275 0.252656870142486 1208 5985051
SGTC_584 0986-0246 15.4 µM 0.666127722790129 0.381190285547896 no 1276 0.252664733017749 1326 53315 YDR232W HEM1
SGTC_1215 3852-0577 11.2 µM 0.665886816379054 0.38127223660127 no 1277 0.252741723911059 1300 2884876
SGTC_1046 2001-0062 216 µM 0.665283484845588 0.38147750005311 no 1278 0.252934595864369 1198 739778
SGTC_1842 st055362 61.2 µM 0.664291129542635 0.381815188373066 no 1279 0.253251998646506 1228 676032
SGTC_2151 5563267 85.4165 µM 0.663715618497478 0.382011070100429 no 1280 0.25343617056094 1242 5310824
SGTC_2779 methotrexate 400 µM 0.663629596663673 0.382040351205807 no 1281 0.25346370484571 1300 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_520 3584-0023 682 µM 0.662689681077931 0.382360334459834 no 1282 0.253764659969035 1221 1340790
SGTC_2940 9060638 45.86 µM 0.662185765989256 0.382531919550686 no 1283 0.253926087670116 1238 4027022
SGTC_462 ag-879 158 µM 0.661278443871313 0.382840924467629 no 1284 0.254216881431403 1249 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3158 9100007 49.47 µM 0.657302689521697 0.384195816371809 no 1285 0.255493153742854 1256 19297233
SGTC_2585 alliin 100 µM 0.65607482311631 0.384614546319598 no 1286 0.255887991398525 1343 87310 A garlic compound which reacts with lipids.
SGTC_3256 9138902 49.47 µM 0.653594987285006 0.385460636008903 no 1287 0.256686387293816 1282 17228773
SGTC_3171 9103192 49.47 µM 0.652571637008124 0.385809949828032 no 1288 0.257016237834372 1297 13018434
SGTC_1174 0739-0097 51.1 µM 0.65161689451584 0.386135928356599 no 1289 0.257324173117684 1276 728447
SGTC_1067 clotrimazole 1.36 µM 0.650629656753191 0.386473086323439 no 1290 0.25764279070189 1279 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2451 5856223 45.7 µM 0.649109371899832 0.386992456229278 no 1291 0.258133842303964 1247 2179896
SGTC_128 0906-2981 13.371 µM 0.648724395876379 0.38712400647349 no 1292 0.258258266412211 1272 6740226
SGTC_2753 fluvastatin 17.09 µM 0.642956957858081 0.389096343182363 no 1293 0.260126014610568 1295 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_734 2023-0417 80 µM 0.642074073660429 0.389398523908991 no 1294 0.260412544368889 1262 3935732
SGTC_1803 st050068 52.4 µM 0.640464645918003 0.389949547357244 no 1295 0.260935283299434 1364 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_955 1216-0110 33 µM 0.637671322828803 0.390906428363622 no 1296 0.261843828434609 1241 3619719
SGTC_259 usnic acid 108.925 µM 0.635985266891835 0.391484324071145 no 1297 0.262393012452713 1346 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1010 4112-3296 15.2 µM 0.63121453594435 0.393120786334286 no 1298 0.263950129419583 1322 704384
SGTC_3090 9117696 49.47 µM 0.6306443164393 0.393316510809556 no 1299 0.264136557748804 1287 7923821
SGTC_1070 indatraline 8.81 µM 0.629938807247065 0.393558709987053 no 1300 0.264367310668974 1273 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_961 1252-1571 372 µM 0.629371356876677 0.393753543880325 no 1301 0.264552982727243 1337 6813498
SGTC_1969 st069479 40.1 µM 0.626633295280587 0.394694029418155 no 1302 0.265449819001223 1310 3895485
SGTC_1694 st024011 44.9 µM 0.626577278060984 0.39471327697132 no 1303 0.265468183208445 1347 2787533
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.625362791596755 0.395130638423568 no 1304 0.265866488505958 1433 16725076
SGTC_3005 9076496 71.4286 µM 0.623175769690367 0.395882517409676 no 1305 0.266584511299953 1320 21368410
SGTC_2436 5633522 8.09 µM 0.62015649939093 0.396921152459142 no 1306 0.26757737887909 1305 5724242
SGTC_3250 9135583 49.47 µM 0.619323887751561 0.397207701544687 no 1307 0.267851505414937 1351 7699353
SGTC_607 4491-0986 66.8 µM 0.619146761728875 0.39726866786083 no 1308 0.267909840093385 1362 698981 YDR232W HEM1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.618321314352436 0.397552817783089 no 1309 0.268181777266436 1283 756377
SGTC_2943 9068529 45.32 µM 0.616348691081562 0.398232088590149 no 1310 0.26883220464946 1317 3270634
SGTC_3108 9121785 49.47 µM 0.61519206650602 0.398630514698697 no 1311 0.269213943236062 1298 17140271
SGTC_1553 gossypol 38.6 µM 0.615046969562151 0.398680504167993 no 1312 0.269261850998815 1251 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2669 eugenol 100 µM 0.612517080447074 0.399552379731584 no 1313 0.270097850374419 1311 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1775 st081588 35.1725 µM 0.612477833482223 0.39956590936989 no 1314 0.270110829716359 1329 1426443 YGL099W LSG1
SGTC_148 3253-0744 288.01 µM 0.611648571516572 0.39985180969761 no 1315 0.270385147402755 1282 6893655
SGTC_2340 7987427 183.45 µM 0.608579935121621 0.400910233332108 no 1316 0.271401453734504 1342 2239331
SGTC_1835 st008666 49.2 µM 0.607855389769878 0.401160247545854 no 1317 0.271641694460987 1292 690455
SGTC_41 0478-0632 82.643 µM 0.606732592594585 0.401547763894241 no 1318 0.272014194359917 1323 3750424
SGTC_1270 0831-1170 17.3 µM 0.605157908800041 0.402091405098976 no 1319 0.272537040034753 1294 6764716
SGTC_3077 9117319 49.47 µM 0.60483000431382 0.402204634165868 no 1320 0.27264597760691 1338 17154678
SGTC_2957 9076800 11.52 µM 0.60411296312833 0.402452265046886 no 1321 0.272884270806434 1288 16459615
SGTC_3213 9129884 49.47 µM 0.60284895238219 0.402888887681034 no 1322 0.273304588932529 1247 17190742
SGTC_2816 7982706 58.44 µM 0.602533496163298 0.402997873483608 no 1323 0.273409536725134 1333 2981853
SGTC_124 0136-0217 7.121 µM 0.602059347464464 0.403161699538995 no 1324 0.273567316771902 1448 3976905
SGTC_2172 5754775 163.918 µM 0.600374563599299 0.403743956977869 no 1325 0.274128317970519 1267 2263357
SGTC_398 bronopol 33.3 µM 0.600122935162464 0.403830937533673 no 1326 0.274212154240258 1324 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1000 4048-0884 8.67 µM 0.599730686068091 0.403966536001804 no 1327 0.274342867028026 1343 13040088
SGTC_1384 3089-0840 101 µM 0.598472959999965 0.40440140310342 no 1328 0.274762198030053 1355 1069836
SGTC_2990 9074105 71.4286 µM 0.597166828494184 0.404853131746013 no 1329 0.275198001814534 1332 6502001
SGTC_160 3453-0671 289.699 µM 0.596131040484029 0.405211451655665 no 1330 0.275543844581477 1285 5322268
SGTC_2356 9061756 188.97 µM 0.595198293278537 0.405534193703707 no 1331 0.275855465505444 1342 20104043
SGTC_3062 9077494 49.47 µM 0.594706038511717 0.405704545839154 no 1332 0.276019992362496 1356 16459633
SGTC_1124 fisetin 1.16336 µM 0.593319311093752 0.406184539557508 no 1333 0.276483738720574 1356 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3241 9133421 49.47 µM 0.591018384013803 0.406981279829708 no 1334 0.277254051585563 1362 17018221
SGTC_1121 fusaric acid 630.51 nM 0.590893402012472 0.407024568309059 no 1335 0.277295923561462 1349 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2623 humulene 100 µM 0.589326309850819 0.407567438994207 no 1336 0.277821199453797 1306 6187145 An anti-inflammatory.
SGTC_752 1896-0090 130 µM 0.588869004135583 0.407725891950108 no 1337 0.277974575935669 1364 772567
SGTC_2440 5628896 157.78 µM 0.587388100327301 0.408239117336741 no 1338 0.278471541964689 1390 5522048
SGTC_3309 9129340 25.759 µM 0.585660382509807 0.408838078097154 no 1339 0.279051881117163 1412 17158987
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.584700555670644 0.40917092050045 no 1340 0.279374540183365 1367 5282362
SGTC_3068 9116768 49.47 µM 0.584269434118499 0.409320443311652 no 1341 0.279519526617587 1340 41904888
SGTC_3094 9117742 49.47 µM 0.583829832950092 0.409472920632535 no 1342 0.279667402361753 1305 17149698
SGTC_1328 1441-0025 69.2 µM 0.583563590175057 0.409565274602115 no 1343 0.279756981200728 1275 4562601
SGTC_2523 spermine 47.74 µM 0.582515230651931 0.409928977015666 no 1344 0.280109842768944 1350 1103 A DNA binding polyamine.
SGTC_1712 st032288 53.4 µM 0.582338508116441 0.409990294171856 no 1345 0.280169346073118 1337 2883011
SGTC_2795 7780010 54.55 µM 0.582103326986378 0.41007189803332 no 1346 0.280248542156895 1373 953673
SGTC_3150 9097574 49.47 µM 0.581864206227061 0.410154872872348 no 1347 0.280329076007976 1380 17217476
SGTC_2418 pentamidine 31.67 µM 0.581780850957697 0.410183798074072 no 1348 0.280357151992458 1321 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1919 st067113 52.3 µM 0.580872906306012 0.410498896542668 no 1349 0.280663056930775 1362 1268243
SGTC_859 0439-0102 54.6 µM 0.578924806197947 0.411175171436826 no 1350 0.28131995567824 1394 610143
SGTC_2987 9018338 71.43 µM 0.578028662957813 0.411486352648936 no 1351 0.281622383923846 1403 5055682
SGTC_2291 7917025 104.35 µM 0.577860797734552 0.411544649198137 no 1352 0.281679052102224 1325 2964612
SGTC_2293 7624732 200 µM 0.576776418154863 0.41192128156802 no 1353 0.282045250894067 1315 894453
SGTC_2003 4023581 200 µM 0.576565281513392 0.411994624096796 no 1354 0.282116579135699 1393 16641307
SGTC_1984 st072354 53.1 µM 0.576448025713596 0.412035356568292 no 1355 0.282156195385274 1331 5762938
SGTC_1267 0828-0272 9.49 µM 0.576249772685293 0.412104228117446 no 1356 0.282223183591303 1457 745334
SGTC_2792 7535235 81.82 µM 0.572195184918732 0.413513351079549 no 1357 0.283594874614186 1339 1281891
SGTC_326 k292-0812 17.5 µM 0.571105504536843 0.413892247110767 no 1358 0.283964063751427 1385 3579357
SGTC_954 1189-0853 2.85 µM 0.571077073358525 0.41390213407571 no 1359 0.283973699453901 1361 2828194
SGTC_886 0866-0150 153 µM 0.571008959785852 0.413925820846925 no 1360 0.283996784681188 1450 271463
SGTC_1626 st003712 1.76 µM 0.569586242503061 0.414420648008602 no 1361 0.284479180816699 1381 24207035
SGTC_292 k038-0015 474 µM 0.567388884236349 0.415185165310357 no 1362 0.285225000161509 1388 46368540
SGTC_363 0455-0021 3.06 µM 0.566975705196834 0.415328956866614 no 1363 0.285365343886627 1405 4597466
SGTC_1496 4469-0713 57.4 µM 0.566804364132495 0.415388589062012 no 1364 0.285423552620419 1417 746691
SGTC_2810 7959871 45.46 µM 0.566233018257256 0.415587449860602 no 1365 0.285617693582925 1439 2974535
SGTC_995 3931-2021 34.6 µM 0.566079507803715 0.415640883899981 no 1366 0.285669866507551 1421 730143
SGTC_1966 st070145 16.1 µM 0.564924787521013 0.416042869774779 no 1367 0.286062461490863 1309 3748532
SGTC_1479 0549-0158 134 µM 0.564883329587153 0.41605730391383 no 1368 0.286076561598628 1404 5440202
SGTC_2640 pentamidine 10.38 µM 0.564336710444247 0.416247627324836 no 1369 0.286262501129056 1422 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3346 9158254 43.5805 µM 0.563554390018028 0.41652005203906 no 1370 0.286528717277357 1379 17639500
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.562760582261676 0.416796517936069 no 1371 0.286798962447145 1373 6708561
SGTC_340 k038-0059 454 µM 0.562433740893638 0.416910361612206 no 1372 0.28691026794133 1418 23733424
SGTC_730 1436-0052 41.2 µM 0.562405415699036 0.416920228024099 no 1373 0.286919915021079 1390 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2610 ononetin 44.17 µM 0.56232024394647 0.41694989590574 no 1374 0.286948923997871 1370 259632
SGTC_2544 sphondin 68.51 µM 0.562069885747927 0.417037105929713 no 1375 0.28703420250938 1431 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1978 st071761 42 µM 0.561778368167532 0.417138658597691 no 1376 0.287133516099035 1346 5147680
SGTC_3113 9123498 49.47 µM 0.559235212486594 0.418024822622015 no 1377 0.288000602245956 1428 8897275
SGTC_2937 9044753 11.33 µM 0.558917167795834 0.418135674854517 no 1378 0.288109126130261 1356 6465530 YGL099W LSG1
SGTC_2925 9010536 32.5 µM 0.556783241138744 0.418879607713885 no 1379 0.288837767726305 1479 2994177
SGTC_1695 st026914 34.495 µM 0.556661456312272 0.418922073308859 no 1380 0.288879378010365 1359 3289191
SGTC_2664 lyso-paf C-16 73.48 µM 0.55607447516215 0.419126763146061 no 1381 0.289079971718001 1407 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2310 7668677 200 µM 0.554401873386187 0.419710146368957 no 1382 0.289651922140587 1454 2197143
SGTC_1675 st018485 24.5 µM 0.5526075375373 0.420336185170359 no 1383 0.290266089753501 1427 3323024
SGTC_2749 bexarotene 57.39 µM 0.552206623726949 0.420476090494789 no 1384 0.290403398379703 1386 82146 An retinoic acid receptor inhibitor.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.551163272245683 0.420840231832594 no 1385 0.290760877402608 1412 7104
SGTC_1376 2910-0861 41.3 µM 0.549837301530127 0.421303108154811 no 1386 0.291215485725087 1458 1112859
SGTC_91 0417-1751 58.384 µM 0.54886255682046 0.421643446205352 no 1387 0.291549887894038 1455 6795624
SGTC_2183 6420625 130.508 µM 0.548721674089785 0.421692641116424 no 1388 0.291598234833498 1393 2897619
SGTC_1902 st060212 70.5 µM 0.548404263117449 0.421803482489859 no 1389 0.291707174931933 1411 688944
SGTC_3355 9151058 44.0485 µM 0.547129885346623 0.422248563358942 no 1390 0.292144750908398 1395 17015728
SGTC_1746 st038117 42 µM 0.545691164148444 0.422751161059859 no 1391 0.292639123326874 1429 2898218
SGTC_2265 7929201 200 µM 0.545005594118206 0.422990699930908 no 1392 0.292874835081272 1371 1265108
SGTC_2911 7942208 15.64 µM 0.543585122763937 0.423487104596547 no 1393 0.29336349985699 1376 1243384
SGTC_1234 0326-0494 15.5 µM 0.542645535964768 0.423815523856561 no 1394 0.293686940144303 1494 1547813
SGTC_1448 4255-0083 152 µM 0.542234834656416 0.423959095318824 no 1395 0.293828370440755 1555 5399660
SGTC_343 4130-2827 29.8 µM 0.542166182478148 0.423983095481491 no 1396 0.293852014777678 1404 1118244
SGTC_1504 k297-0033 30 µM 0.541413182235978 0.424246355845641 no 1397 0.294111411586474 1334 4388117
SGTC_1554 st069299 38.7 µM 0.540961463967918 0.424404299667907 no 1398 0.294267072231633 1424 24207999
SGTC_2570 licareol 100 µM 0.539039767885963 0.425076358339721 no 1399 0.294929707341364 1405 443158
SGTC_1575 cyproterone acetate 48 µM 0.539029068380197 0.425080100799743 no 1400 0.294933398646036 1359 9880 An androgen receptor antagonist and liver toxin.
SGTC_303 1348-1668 34.2 µM 0.538754679112861 0.425176078647487 no 1401 0.295028069579536 1434 5380509
SGTC_360 0957-0399 1.01 µM 0.538574470019451 0.425239115891037 no 1402 0.295090253690145 1495 6752301 YPR165W RHO1
SGTC_2202 7226349 200 µM 0.537139247309047 0.425741225711478 no 1403 0.295585716215341 1403 844334
SGTC_2247 cerulenin 830 nM 0.536842483248567 0.425845063082615 no 1404 0.295688211755134 1477 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1682 st012968 530 nM 0.534746183074081 0.426578701929444 no 1405 0.296412690773177 1380 24207270
SGTC_2908 7930301 100 µM 0.534026934109064 0.426830475025202 no 1406 0.296661449763615 1345 2223178
SGTC_2066 5222451 176 µM 0.533920961653409 0.426867573205053 no 1407 0.296698109409612 1391 2281147
SGTC_168 3970-0862 530.542 µM 0.533652954042825 0.426961398532791 no 1408 0.29679083204153 1445 3135186
SGTC_224 benfluorex 43.875 µM 0.531758450901041 0.427624752391675 no 1409 0.297446651519984 1477 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_539 4859-0462 2.54 µM 0.531177048353336 0.427828369650358 no 1410 0.297648048068439 1507 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2108 5365811 200 µM 0.530299222971795 0.428135835730806 no 1411 0.297952242675437 1510 780283
SGTC_508 roscovitine 141 µM 0.530126657838949 0.42819628332814 no 1412 0.298012058684292 1500 160355 A CDKinase inhibitor.
SGTC_709 3807-1509 243 µM 0.529897075915933 0.428276705868281 no 1413 0.298091646825705 1472 1886677 YPL242C IQG1
SGTC_223 busulfan 5 mM 0.529747969449124 0.428328939454602 no 1414 0.298143342086324 1464 2478 A DNA alkylator.
SGTC_3135 9127742 49.47 µM 0.529462700991398 0.428428875537678 no 1415 0.298242256132507 1424 3643468
SGTC_1374 2889-5571 141 µM 0.527518465511885 0.42911010773243 no 1416 0.298916798383475 1435 2853281
SGTC_1337 1486-1011 40.3 µM 0.526245971273498 0.429556085923704 no 1417 0.299358658433329 1434 X1337
SGTC_3239 9133757 49.47 µM 0.526191605479868 0.429575141815142 no 1418 0.299377542971908 1499 17036923
SGTC_3348 9149464 3.537 µM 0.525426128353056 0.42984346853388 no 1419 0.299643496955939 1424 1951442
SGTC_2979 9012552 45.46 µM 0.525369030144089 0.429863484769435 no 1420 0.299663339194142 1488 17100905
SGTC_230 MPP+ 141.667 µM 0.525235159189082 0.429910415014194 no 1421 0.299709863116264 1391 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_287 k060-0039 29.6 µM 0.525110037156413 0.429954279103164 no 1422 0.29975334949949 1527 5861974
SGTC_1258 0671-0043 57.1 µM 0.524628724358731 0.430123021208629 no 1423 0.299920657243009 1415 4298767
SGTC_2386 9075165 157.42 µM 0.524419924177003 0.43019622785066 no 1424 0.299993250809963 1414 16452277
SGTC_3243 9134147 49.47 µM 0.523683578354369 0.430454414410098 no 1425 0.30024931962254 1490 24282180
SGTC_2370 9071495 200 µM 0.522747032945374 0.430782840336766 no 1426 0.300575151756066 1409 21791103
SGTC_2023 5144124 124 µM 0.522153646278456 0.430990952813021 no 1427 0.300781678624226 1431 2830192
SGTC_2524 avocatin b 10.57 µM 0.522044589061727 0.431029203428815 no 1428 0.300819642701993 1466 6710748
SGTC_603 3794-0023 45.9 µM 0.520987241222887 0.431400090009632 no 1429 0.301187829723966 1522 3802260
SGTC_1481 3346-2004 36 µM 0.520004436647958 0.431744883253989 no 1430 0.301530241410154 1446 2770522
SGTC_2694 st077685 81.9 µM 0.51844474522712 0.432292169964225 no 1431 0.302074001195548 1388 2838096
SGTC_2067 5224629 34.075 µM 0.517189870320453 0.432732592704116 no 1432 0.302511811274786 1423 2835000
SGTC_277 nystatin 15.5 µM 0.516528032874415 0.432964911120119 no 1433 0.30274283255802 1431 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1047 2043-3044 82 µM 0.51652304437909 0.432966662271605 no 1434 0.302744574144516 1405 669592
SGTC_1612 st002233 45.4 µM 0.513534862291046 0.434015863122349 no 1435 0.303788615381005 1481 1035021
SGTC_3081 9117243 49.47 µM 0.513250396822664 0.434115768077644 no 1436 0.303888088489172 1553 45595589
SGTC_950 1165-0508 94.1 µM 0.511368106086623 0.434776938860558 no 1437 0.304546661746677 1437 6148369
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.511150734491567 0.434853304285425 no 1438 0.304622756299002 1458 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2427 5545055 42.75 µM 0.510695494928447 0.435013243644866 no 1439 0.304782147894417 1512 5372858
SGTC_2489 cantharidin 73.42 µM 0.50930392376617 0.435502210299847 no 1440 0.305269604014198 1424 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3129 9127257 49.47 µM 0.509288417086375 0.435507659553665 no 1441 0.305275037826983 1356 837894
SGTC_1518 st038567 90.8 µM 0.509061873452584 0.435587271399754 no 1442 0.305354427585259 1447 77966
SGTC_646 4092-0839 27.3 µM 0.508266329231222 0.4358668617957 no 1443 0.305633289937483 1539 877796
SGTC_2147 5545932 89.7195 µM 0.502811480492713 0.437784799774916 no 1444 0.307548410622645 1470 797404
SGTC_750 4073-0104 132 µM 0.502592425181097 0.437861850997742 no 1445 0.307625428001899 1380 22330957
SGTC_1800 st050079 29.0735 µM 0.502285956821154 0.437969653121812 no 1446 0.307733193053945 1430 3645560
SGTC_576 1073-0113 22.7 µM 0.501253369826903 0.438332905767549 no 1447 0.30809640902294 1574 5439563
SGTC_2593 nobiletin 86.24 µM 0.500496350383551 0.438599249835429 no 1448 0.308362812655422 1437 72344 An anti-infammatory.
SGTC_698 k064-0052 127 µM 0.499717136660719 0.438873431616224 no 1449 0.308637132141298 1548 5088751
SGTC_2521 angolensin 13.4 µM 0.499478788198264 0.438957305108085 no 1450 0.308721063233716 1520 821428 A flavenoid.
SGTC_2069 5228469 200 µM 0.499439632335058 0.438971084099744 no 1451 0.308734852381484 1431 2835210
SGTC_2849 9019321 12.99 µM 0.499389154866294 0.438988847286068 no 1452 0.308752628949244 1482 16489627
SGTC_1193 1488-0126 41.5 µM 0.497935817151378 0.439500334138343 no 1453 0.309264640572123 1480 1384710
SGTC_3262 9137218 49.47 µM 0.497131475441303 0.439783457182552 no 1454 0.309548169958467 1414 17650664
SGTC_2245 6637752 200 µM 0.496997102409433 0.439830758621042 no 1455 0.30959554733208 1590 681890
SGTC_3120 9124077 49.47 µM 0.496180448044513 0.440118252358472 no 1456 0.309883552144968 1493 18774327 YGL155W CDC43
SGTC_2417 cerulenin 830 nM 0.495714062834221 0.440282452060284 no 1457 0.31004808191786 1523 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_143 4032-1194 15.74 µM 0.495501205232372 0.440357396005125 no 1458 0.310123185736744 1496 1806963
SGTC_1249 0481-0015 10.2 µM 0.495494721513001 0.440359678858278 no 1459 0.310125473550509 1443 4227577
SGTC_391 gliotoxin 8.33 µM 0.495153973747816 0.440479655547891 no 1460 0.310245718495488 1552 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2448 5185112 27.17 µM 0.495082665468685 0.440504763759517 no 1461 0.310270884720769 1468 5718189
SGTC_1443 4112-3303 14 µM 0.492478192318783 0.441421982565415 no 1462 0.311190667364307 1488 704433
SGTC_331 k048-0133 24.5 µM 0.492256022086043 0.441500238999682 no 1463 0.311269182599376 1467 6813582
SGTC_2365 9042475 200 µM 0.491775194185244 0.441669611885478 no 1464 0.311439137173729 1469 6464479
SGTC_610 4215-0184 155 µM 0.491692372637779 0.441698787069939 no 1465 0.311468415533604 1522 5605015
SGTC_1113 artemisinin 1.17947 µM 0.489098064286086 0.442612832069309 no 1466 0.312386135913897 1552 2240 An anti-malaria and mitochondrial poison.
SGTC_2836 9010338 19.48 µM 0.488766279659246 0.44272975090585 no 1467 0.312503586790298 1367 2994051
SGTC_86 0417-1630 471.922 µM 0.485437382058507 0.443903108089952 no 1468 0.313683060365422 1526 3634867
SGTC_1028 k015-0029 4.8 µM 0.483940348945515 0.444430937606488 no 1469 0.314214101907008 1485 4588309
SGTC_2007 4011539 71.82 µM 0.483796038608016 0.444481824306841 no 1470 0.314265313367965 1499 45595301
SGTC_1063 disulfiram 1.84 µM 0.483124553372939 0.444718615402223 no 1471 0.314503650585502 1496 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1042 0350-0096 82 µM 0.482149858177335 0.445062364881901 no 1472 0.314849746830967 1473 3122515
SGTC_671 0560-0003 407 µM 0.482132351884365 0.445068539271601 no 1473 0.314855964479953 1544 3238678
SGTC_841 0251-0215 91.2 µM 0.480838370289311 0.445524957476649 no 1474 0.315315688608209 1544 3888614
SGTC_3318 9139014 38.6185 µM 0.479369791327136 0.446043047792783 no 1475 0.3158377900768 1504 16643984
SGTC_2051 5263410 176 µM 0.479205593580147 0.446100979779221 no 1476 0.31589618766527 1523 227584
SGTC_2402 5553605 200 µM 0.478898051128025 0.446209489510018 no 1477 0.316005578736725 1593 6758546
SGTC_459 nigericin 15.3 µM 0.478608526694141 0.44631164565257 no 1478 0.316108575627593 1538 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1754 st042065 16.137 µM 0.477692725189016 0.446634801566412 no 1479 0.316434461447074 1450 1126236 YIL048W NEO1
SGTC_795 0685-0265 78 µM 0.476312864546258 0.447121775390456 no 1480 0.316925750846273 1511 302754
SGTC_3137 9097352 49.47 µM 0.476156980169753 0.447176794385914 no 1481 0.316981272670433 1589 44120435
SGTC_2132 5317594 122.667 µM 0.475995530538995 0.447233778695406 no 1482 0.317038781033144 1552 794577
SGTC_433 pimozide 108 µM 0.475883569152943 0.447273296565612 no 1483 0.317078664277043 1448 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2126 5251174 33.877 µM 0.475624333328488 0.447364798403023 no 1484 0.317171018249424 1680 790722
SGTC_1963 st076565 50.3 µM 0.474394443120616 0.447798947846213 no 1485 0.317609327468549 1517 4914280
SGTC_3109 9122853 49.47 µM 0.474258420051989 0.44784696764082 no 1486 0.317657819194186 1586 1234709
SGTC_2975 9084847 53.72 µM 0.473553465134417 0.448095847880277 no 1487 0.317909183142851 1518 27211724
SGTC_1722 st034304 3.6505 µM 0.47343754534325 0.448136774648075 no 1488 0.317950524400096 1487 4036148 YLR033W RSC58
SGTC_183 3914-0051 30.55 µM 0.471215190258607 0.448921507995667 no 1489 0.318743536095288 1653 1596232
SGTC_1450 4112-4260 37.6 µM 0.47058676126094 0.449143448246098 no 1490 0.318967931711993 1599 1633175
SGTC_1354 1498-1681 81 µM 0.470299129807771 0.44924503543518 no 1491 0.31907065955248 1540 5754243
SGTC_2755 lomerizine 42.69 µM 0.468738416780992 0.44979631410407 no 1492 0.319628311775983 1494 3949 A calcium channel blocker.
SGTC_2913 7966556 36.57 µM 0.468718987160574 0.449803177692463 no 1493 0.319635256671253 1604 2976516
SGTC_835 0312-0010 67.2 µM 0.468062037389103 0.450035256558891 no 1494 0.319870113051865 1506 1626196
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.467502932305527 0.450232783561071 no 1495 0.320070047323453 1492 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2488 5268135 45.7 µM 0.466926411986737 0.450436476126197 no 1496 0.320276263963149 1600 1270356 YLR208W SEC13
SGTC_1904 st060225 78 µM 0.466373354515563 0.450631891214765 no 1497 0.320474140309525 1489 66595
SGTC_1470 k295-0292 231 µM 0.464723147272549 0.451215039710147 no 1498 0.32106486492893 1587 5045612
SGTC_1159 4092-0538 61.2 µM 0.463682713210313 0.451582761408104 no 1499 0.321437542089567 1572 717301
SGTC_994 3910-0338 138 µM 0.462990073763678 0.451827584747432 no 1500 0.321685741061112 1625 3479481
SGTC_2426 5582046 32.21 µM 0.462228669694885 0.452096735064513 no 1501 0.321958672853754 1560 2251934
SGTC_272 doxorubicin 8.13 µM 0.461513996632735 0.452349386374382 no 1502 0.3222149409297 1533 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_662 k832-1615 104 µM 0.460890974458155 0.452569652997693 no 1503 0.322438413728064 1593 5878478
SGTC_1761 st044296 37 µM 0.460662397077946 0.45265046914254 no 1504 0.322520418602124 1505 1826700
SGTC_404 fumagillin 50 µM 0.459654117348222 0.453006981328222 no 1505 0.322882254049184 1550 12015870 A methionine aminopeptidase binder.
SGTC_3050 9093513 49.47 µM 0.459219281215636 0.453160744396924 no 1506 0.323038352932472 1513 25236664
SGTC_441 propafenone 146 µM 0.457496956834042 0.453769846927767 no 1507 0.3236569445619 1499 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1806 st050005 60.3 µM 0.457157030132285 0.453890075397722 no 1508 0.323779090614943 1506 5194765
SGTC_1782 st039423 80.636 µM 0.456656396346419 0.454067151950556 no 1509 0.323959018198019 1491 2068169
SGTC_596 1155-0152 116 µM 0.456568324849328 0.454098304203665 no 1510 0.323990675315181 1521 280313
SGTC_3196 9111891 49.47 µM 0.456374995146558 0.454166688905033 no 1511 0.324060171740243 1517 18891510
SGTC_293 4049-0273 38.5 µM 0.456087797332762 0.454268279200169 no 1512 0.324163422350844 1507 1380311
SGTC_427 1354-0053 47.3 µM 0.456007325856086 0.454296744859939 no 1513 0.324192355112431 1614 6813657
SGTC_543 3844-1095 191 µM 0.455150167651991 0.454599967128337 no 1514 0.324500604128196 1631 4230703
SGTC_1790 st045711 43.5 µM 0.45369500225391 0.45511479671564 no 1515 0.325024182278139 1673 585119
SGTC_2088 5278280 127.392 µM 0.453449862096028 0.455201533411518 no 1516 0.325112419386933 1572 791502
SGTC_1948 st076329 66.6 µM 0.452930909330253 0.455385158871426 no 1517 0.325299246482032 1481 24208413
SGTC_760 0568-0725 82.9 µM 0.45267382021304 0.45547613042808 no 1518 0.325391816865562 1656 3916171
SGTC_871 0574-0004 149 µM 0.449823163325589 0.456484997111753 no 1519 0.326418977213408 1552 9551173
SGTC_2115 tiliquinol 12.7705 µM 0.446654697337509 0.457606667547756 no 1520 0.327562198100899 1581 71208 A bioactive hydroxyquinoline.
SGTC_2956 9076196 2.52 µM 0.44645443744133 0.457677573108752 no 1521 0.327634508791195 1568 16423868
SGTC_3298 9116858 71.43 µM 0.445935613515103 0.457861278163611 no 1522 0.327821877995924 1632 2506942
SGTC_1059 3448-6867 171 µM 0.445434036118208 0.458038885130448 no 1523 0.328003059969149 1601 3934407
SGTC_2728 chlorpromazine 9.18 µM 0.444893613928239 0.458230256291676 no 1524 0.32819831893526 1586 2726 A thorazine and dopamine antagonist.
SGTC_147 4466-0538 29.23 µM 0.444079043231398 0.458518725609461 no 1525 0.328492718709079 1591 6742687 YHR072W ERG7
SGTC_2690 usnic acid 100 µM 0.443000713366517 0.458900635288377 no 1526 0.328882609360105 1704 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_220 paclitaxel 373.376 µM 0.442186585502179 0.459188998287237 no 1527 0.329177096198429 1595 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2031 5180455 200 µM 0.441963853213191 0.459267893513035 no 1528 0.329257681540097 1536 29949
SGTC_3049 9092223 49.47 µM 0.44182898381534 0.459315667122201 no 1529 0.329306481628808 1574 8623917
SGTC_328 k915-0120 63.5 µM 0.440687423392888 0.459720055566088 no 1530 0.329719651334826 1641 6624543
SGTC_2549 cedrol 20.94 µM 0.440497729817973 0.459787257012786 no 1531 0.329788328074453 1622 6708665 A sedative which affects the nervous system.
SGTC_3117 9124945 49.47 µM 0.43931962827667 0.460204640645624 no 1532 0.330214976858831 1465 17592065
SGTC_794 k038-0031 316 µM 0.439152654682254 0.460263800434212 no 1533 0.330275464130334 1554 6624242
SGTC_1081 sertraline 6 µM 0.438422807079044 0.460522400312316 no 1534 0.330539908223802 1659 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2949 9072542 2.23 µM 0.438382398059763 0.460536718540112 no 1535 0.330554552009417 1529 16457352
SGTC_2021 4019055 173 µM 0.438290475851202 0.460569289754297 no 1536 0.330587864576337 1570 44827708 YER133W GLC7
SGTC_3018 9082602 49.47 µM 0.437978892412242 0.460679696498125 no 1537 0.330700792257824 1574 17332089
SGTC_2967 9089538 49.85 µM 0.436712677857583 0.461128399152906 no 1538 0.3311598668962 1743 728216
SGTC_2044 5102272 200 µM 0.436489719530502 0.461207413015261 no 1539 0.331240728252838 1562 592666
SGTC_42 0133-0086 60.653 µM 0.436256632009561 0.461290018184512 no 1540 0.33132527162647 1482 162923 Model of phenazepam hydroxylation.
SGTC_1342 1486-1464 234 µM 0.434689070914765 0.461845597997353 no 1541 0.33189406619494 1566 3253938
SGTC_2275 7947463 200 µM 0.43437306775779 0.461957605858851 no 1542 0.332008775946935 1561 1225414
SGTC_3233 9132340 49.47 µM 0.434119363701739 0.462047533881042 no 1543 0.332100882402218 1523 17682950
SGTC_3168 9103419 49.47 µM 0.433199648637052 0.462373552613915 no 1544 0.332434867062396 1587 16649256
SGTC_2263 7948595 193.29 µM 0.432793213922051 0.462517632835377 no 1545 0.332582501886475 1570 2971371
SGTC_2252 omeprazole 400 µM 0.432494936506633 0.462623374659769 no 1546 0.332690865784942 1649 4594 A proton pump inhibitor.
SGTC_3191 9110352 49.47 µM 0.431602984778484 0.462939594695111 no 1547 0.333014994369288 1609 17122424
SGTC_3028 9087778 49.47 µM 0.431218232007816 0.463076006779408 no 1548 0.333154849188535 1505 17217395
SGTC_536 3852-0578 10.6 µM 0.431038179615409 0.463139844906653 no 1549 0.333220304888554 1680 2869208
SGTC_704 1310-0270 142 µM 0.428874320569026 0.463907121544765 no 1550 0.334007344533115 1539 5718033
SGTC_982 1491-0518 27.5 µM 0.428642659608021 0.463989273554037 no 1551 0.334091647703393 1597 3091256
SGTC_726 3448-4391 34.2 µM 0.427164102766933 0.46451363795436 no 1552 0.334629902756499 1702 1356692
SGTC_1759 st043059 70 µM 0.426959664375946 0.464586146101136 no 1553 0.334704353459576 1536 669426
SGTC_1903 st060211 78.3 µM 0.426903025788739 0.464606234312195 no 1554 0.33472498078731 1692 688960
SGTC_2896 9052656 71.43 µM 0.426672349126935 0.464688050163363 no 1555 0.334808996563872 1565 6469436
SGTC_1094 duloxetine 25.4 µM 0.424525826422953 0.465449444871968 no 1556 0.335591187193429 1591 60834 A selective serotonin reuptake inhibitor.
SGTC_1715 st032160 10.2275 µM 0.424070028180247 0.465611137791754 no 1557 0.335757371483804 1659 5289825
SGTC_1959 st077091 55.8 µM 0.421937772973641 0.466367623247732 no 1558 0.336535219102655 1562 821356 YKL052C ASK1
SGTC_937 3122-0005 46.7 µM 0.420732260329894 0.466795371209493 no 1559 0.336975300632484 1710 759535
SGTC_2869 9037858 32.47 µM 0.420632159019893 0.466830891549078 no 1560 0.337011853421087 1531 27187042
SGTC_399 oxolinic acid 75 µM 0.42060130848597 0.466841838726226 no 1561 0.337023119048923 1572 4628 A DNA gyrase inhibitor.
SGTC_1351 1496-0003 46.5 µM 0.42045758625657 0.466892838261756 no 1562 0.337075603734947 1648 3891978
SGTC_944 3370-0224 231 µM 0.420341450429979 0.46693404921647 no 1563 0.337118016696555 1559 4580514
SGTC_2891 9063876 19.48 µM 0.420279823204721 0.466955917864463 no 1564 0.337140523883823 1662 6472478
SGTC_680 0417-1641 114 µM 0.419964962131634 0.467067649031882 no 1565 0.337255524967857 1574 2835990
SGTC_3186 9110464 49.47 µM 0.419298322342033 0.467304220463651 no 1566 0.337499061253496 1639 17018021
SGTC_3189 9110682 49.47 µM 0.417235463128889 0.468036343110588 no 1567 0.338253094145738 1599 17122418
SGTC_211 3455-0679 143.504 µM 0.416975573597169 0.468128587378329 no 1568 0.338348137164719 1610 748649
SGTC_816 0325-0417 81.3 µM 0.416036098239132 0.468462055664874 no 1569 0.338691794303386 1575 68101
SGTC_931 2812-0076 566 µM 0.413576246455384 0.469335288234104 no 1570 0.339592236123721 1589 3450959
SGTC_677 0929-0063 136 µM 0.412977784056172 0.46954776125327 no 1571 0.339811445253955 1571 1539583
SGTC_860 0443-0016 25.1 µM 0.412561906883978 0.469695415871097 no 1572 0.33996380766188 1623 5337942
SGTC_806 3966-4455 5.86 µM 0.411218330892469 0.470172472594728 no 1573 0.340456224041253 1544 714982
SGTC_849 0386-0493 241 µM 0.411035917159171 0.470237244631497 no 1574 0.340523099099526 1583 726119
SGTC_2085 5307070 144.047 µM 0.410487593108993 0.47043194997813 no 1575 0.340724151443365 1570 2840351
SGTC_1613 st002381 52.1 µM 0.408159414033235 0.471258745332531 no 1576 0.34157832136201 1592 551167
SGTC_2575 plumbagin 510 nM 0.407057673501224 0.471650044703043 no 1577 0.341982814823621 1553 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2706 st078239 82.5 µM 0.407036957921619 0.471657402409441 no 1578 0.341990422089013 1615 15434492
SGTC_878 0828-0289 13.7 µM 0.406485164569812 0.471853390508555 no 1579 0.34219307764903 1605 745350 YLR208W SEC13
SGTC_783 0848-0141 92.7 µM 0.406390470473005 0.471887025011017 no 1580 0.342227860249639 1582 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_428 3448-4153 16.5 µM 0.406288743884419 0.471923157615496 no 1581 0.342265227484175 1543 3834874
SGTC_685 1278-0033 54.9 µM 0.405891649645978 0.472064205044257 no 1582 0.342411106915296 1687 3590572
SGTC_3083 9117465 49.47 µM 0.405485326252019 0.472208534285184 no 1583 0.342560401176502 1570 16420915
SGTC_2952 9073731 13.78 µM 0.402845128902896 0.473146441043752 no 1584 0.343531079767259 1562 16457353
SGTC_771 0250-0039 27.3 µM 0.40154872582724 0.473607031598908 no 1585 0.344008085766401 1631 3005115
SGTC_2062 5245942 200 µM 0.401092864293691 0.473769000073432 no 1586 0.34417587713904 1626 1376160
SGTC_3208 9114115 49.47 µM 0.400031165945598 0.474146240290895 no 1587 0.344566780974061 1535 650895
SGTC_991 3996-0057 64.7 µM 0.399244300717947 0.474425842412738 no 1588 0.344856601910494 1635 715343
SGTC_231 b-estradiol 524 µM 0.398960714744514 0.474526614022275 no 1589 0.344961075613368 1579 450 A steroid.
SGTC_165 k038-0023 64.381 µM 0.397813006298285 0.474934466101408 no 1590 0.345384014610246 1579 46368543
SGTC_493 zm226600 134 µM 0.395878377357013 0.475622019135773 no 1591 0.346097376541654 1653 5240098 A potassium channel opener. YCR052W RSC6
SGTC_814 3342-0569 96 µM 0.395530965744268 0.475745494440479 no 1592 0.346225536691157 1645 4346283
SGTC_2822 7994718 71.43 µM 0.395013434814494 0.475929437021119 no 1593 0.346416486515212 1663 1018011
SGTC_1944 st076371 56.9 µM 0.394928095110029 0.475959769239135 no 1594 0.346447977469171 1591 24208455
SGTC_2847 9005661 71.43 µM 0.39460131519362 0.476075917631258 no 1595 0.346568571378823 1628 2991449
SGTC_1217 1183-1422 255 µM 0.393617116375806 0.476425746689248 no 1596 0.346931871154943 1709 2849664
SGTC_695 3505-6186 243 µM 0.393027094477418 0.476635476057086 no 1597 0.34714973492672 1680 1819379
SGTC_3255 9139072 49.47 µM 0.392788319751347 0.476720352838522 no 1598 0.347237916125129 1640 17646060
SGTC_2486 5283202 22.39 µM 0.389063188522716 0.478044652243268 no 1599 0.348614701832366 1603 1377751
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.385181219071753 0.479424966053488 no 1600 0.350051578458089 1732 688662
SGTC_2539 epi(13)torulosol 80 µM 0.38504504476637 0.479473390195901 no 1601 0.35010202131384 1593 6708597
SGTC_2086 5274770 176.623 µM 0.38444086213918 0.479688243664418 no 1602 0.350325859721881 1645 689278
SGTC_1645 Cervolide 78 µM 0.383810417516412 0.47991244245593 no 1603 0.350559483145899 1642 23173 A fragrance.
SGTC_154 3389-1638 511.116 µM 0.383520157494702 0.480015666900061 no 1604 0.350667063611547 1533 5238686
SGTC_2972 9093619 59.92 µM 0.383343822396014 0.480078377164152 no 1605 0.350732425384414 1585 25236256
SGTC_688 0527-0193 473 µM 0.381821970993365 0.48061961534324 no 1606 0.351296710387622 1697 4007154
SGTC_2927 9011802 47.9 µM 0.381374654019569 0.480778708032566 no 1607 0.351462632799467 1578 43912568
SGTC_1344 1488-0097 29.1 µM 0.380931346684147 0.480936377675096 no 1608 0.351627095852587 1681 747966
SGTC_3000 9075062 71.4286 µM 0.380582814682476 0.481060340985841 no 1609 0.351756417609442 1653 17057871
SGTC_2148 5546263 113.568 µM 0.380283598870952 0.481166765336647 no 1610 0.351867454427652 1670 792097
SGTC_731 3966-0296 387 µM 0.379898848351554 0.481303614435546 no 1611 0.352010251124036 1660 660956
SGTC_1352 1496-0991 99 µM 0.379743357796701 0.481358920360069 no 1612 0.352067965969069 1640 3000039
SGTC_2297 7971671 152.32 µM 0.378329018167658 0.481861998517532 no 1613 0.352593095620604 1754 909016
SGTC_2880 9042983 58.44 µM 0.378144977063061 0.481927463760711 no 1614 0.352661448861595 1645 6464714
SGTC_719 2810-4230 27.3 µM 0.377427860047398 0.482182554016342 no 1615 0.352927832944613 1679 721079
SGTC_369 0957-0393 4.5 µM 0.376684715869769 0.482446910254562 no 1616 0.353203961295967 1601 6997992
SGTC_298 1391-0729 10 µM 0.376469399601522 0.482523505450803 no 1617 0.353283980310435 1656 3237558
SGTC_203 k066-0004 30.888 µM 0.37492159971547 0.483074128438241 no 1618 0.353859387300972 1764 6795412
SGTC_1734 st037168 69.4 µM 0.374914779403237 0.48307655480647 no 1619 0.353861923546618 1640 708907
SGTC_1591 genipin 88.4 µM 0.374849244263693 0.483099869369323 no 1620 0.353886294200181 1727 442424 A DNA cross-linking agent.
SGTC_854 0422-0053 192 µM 0.373825833326149 0.483463962081317 no 1621 0.354266949224342 1619 3596728
SGTC_120 rhodamine 6G 52.259 µM 0.373232754378685 0.483674964517623 no 1622 0.354487610074905 1627 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3119 9125183 49.47 µM 0.372272609987524 0.484016569188452 no 1623 0.354844944759079 1740 22695334
SGTC_3197 9113331 49.47 µM 0.368783514508257 0.48525803285746 no 1624 0.356144546720895 1781 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2239 6685329 187.64 µM 0.36622478725178 0.486168551420831 no 1625 0.357098673761461 1662 805680
SGTC_3238 9133470 49.47 µM 0.36613475491725 0.486200590608754 no 1626 0.357132262355039 1770 3534688
SGTC_3104 9120930 49.47 µM 0.366108513770528 0.486209928882005 no 1627 0.357142052415238 1687 17014836
SGTC_345 1362-0200 395 µM 0.365701041538763 0.486354934451416 no 1628 0.357294084425895 1618 1419823
SGTC_3030 9087619 49.47 µM 0.364044413292491 0.486944490723718 no 1629 0.357912422252338 1646 25236973
SGTC_1744 st037937 38.9 µM 0.363025078578714 0.487307263000567 no 1630 0.358293075224389 1734 1016152
SGTC_1897 st060201 15 µM 0.360853763499368 0.488080049615068 no 1631 0.359104384647496 1645 611878
SGTC_649 1123-0311 367 µM 0.360239527894907 0.488298668720561 no 1632 0.359334008624034 1775 693629 YIL048W NEO1
SGTC_3334 9142812 21.919 µM 0.36019519577646 0.488314447571627 no 1633 0.359350583575842 1728 45283678
SGTC_829 1635-0120 117 µM 0.35919098644678 0.488671874311143 no 1634 0.359726109551326 1784 285054
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.358102701740882 0.489059236138467 no 1635 0.360133228628599 1674 442882
SGTC_475 α-linolenic acid 10 µM 0.35744889105206 0.489291957160648 no 1636 0.360377890596242 1768 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_818 4072-2707 53.5 µM 0.356946468554166 0.489470794707351 no 1637 0.360565940573011 1611 882871
SGTC_2125 5246583 200 µM 0.356917288929603 0.489481181275121 no 1638 0.360576863150328 1858 835267
SGTC_1445 4239-0156 97.7 µM 0.356414799755131 0.489660044794559 no 1639 0.360764973775282 1817 4008346
SGTC_2566 crystal violet carbinol 226 nM 0.355922108095862 0.489835422858982 no 1640 0.360949449340149 1588 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2971 9092186 9.93 µM 0.355547065358817 0.489968924041716 no 1641 0.361089896017838 1565 25236400
SGTC_190 3970-0790 3.722 µM 0.355010476175313 0.490159931665774 no 1642 0.361290871462384 1776 2832352
SGTC_1323 1348-1351 11.2 µM 0.354942481600697 0.490184135599574 no 1643 0.361316341053448 1674 6989654
SGTC_2444 5485484 36.41 µM 0.354253447584055 0.490429412100294 no 1644 0.361574475931659 1756 6790631
SGTC_1521 st012942 49.4 µM 0.354186712115536 0.490453168221583 no 1645 0.361599480589163 1870 24207259
SGTC_962 1254-0300 21.5 µM 0.351741804401716 0.491323515542488 no 1646 0.362515953052429 1703 7340576
SGTC_2390 9097792 176.6 µM 0.350689921293994 0.491697981746837 no 1647 0.362910493793651 1636 4497149
SGTC_344 k064-0035 6.43 µM 0.349304304781659 0.492191266830365 no 1648 0.363430433503299 1646 5088750
SGTC_1486 3970-0793 4.53 µM 0.348077364592719 0.492628072493902 no 1649 0.363891041551417 1811 2844330
SGTC_1250 0485-0349 40.2 µM 0.347809779790416 0.492723337137658 no 1650 0.363991522247826 1676 6842794 YDL195W SEC31
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.346982349029422 0.493017918863633 no 1651 0.364302289690642 1791 77254
SGTC_573 3702-0553 84.7 µM 0.345960949110717 0.493381562682483 no 1652 0.364686031348952 1713 1222756
SGTC_1967 st070177 51.4 µM 0.345824095683033 0.493430286336858 no 1653 0.364737457721721 1766 5729214
SGTC_2858 9025781 8.96 µM 0.343586086451581 0.494227093703439 no 1654 0.365578794892999 1792 4894980 YPL153C RAD53
SGTC_1889 st059080 5.18 µM 0.343577466596481 0.494230162711452 no 1655 0.365582036617764 1842 176925 Isolated from Daphnopsis sellowiana.
SGTC_2717 st081029 62.2815 µM 0.343565202550086 0.494234529195724 no 1656 0.365586648853711 1827 5292846
SGTC_1266 0828-0227 32.9 µM 0.34341826834567 0.494286843621887 no 1657 0.365641909061374 1779 3913820
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.342863489397355 0.494484367891361 no 1658 0.365850579960836 1670 2333 A French combination drug.
SGTC_448 monastrol 171 µM 0.341113581888707 0.495107416030213 no 1659 0.366509038454919 1747 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1977 st070720 65.3 µM 0.340516012237328 0.495320181319023 no 1660 0.366733983232488 1701 682188
SGTC_2831 7999036 19.48 µM 0.338096855873625 0.496181537404716 no 1661 0.367645099915373 1884 2988270
SGTC_1635 st007035 42.4 µM 0.337917162113185 0.496245519276372 no 1662 0.367712807023414 1693 3716403
SGTC_1417 3966-0327 90.4 µM 0.33659908411303 0.496714837791668 no 1663 0.368209573363982 1732 651118
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.336560324688027 0.496728638652232 no 1664 0.368224184624066 1765 1377
SGTC_515 4092-1064 102 µM 0.335540892062929 0.497091623914697 no 1665 0.368608551662104 1855 717353
SGTC_2166 5933061 31.504 µM 0.335070558237248 0.497259094612603 no 1666 0.368785930753921 1834 2877375
SGTC_114 0364-0001 490.298 µM 0.334991065077 0.497287399610291 no 1667 0.368815913126477 1671 4003655
SGTC_2825 7998094 58.44 µM 0.334614067730164 0.497421636613655 no 1668 0.368958115787745 1729 2987815
SGTC_2257 7960413 200 µM 0.333741120019186 0.497732467176842 no 1669 0.369287458789012 1790 2974689 YIL048W NEO1
SGTC_2363 9053361 176 µM 0.333275200482095 0.497898367760129 no 1670 0.369463278757345 1843 6469797 YMR079W SEC14
SGTC_2380 9035439 200 µM 0.328118559339088 0.499734517605817 no 1671 0.371411010902105 1810 6462575
SGTC_1473 k844-0725 134 µM 0.328056447704055 0.499756634104768 no 1672 0.371434491491407 1774 54682906
SGTC_1377 2944-0135 198 µM 0.32795963216431 0.499791107853096 no 1673 0.371471092446858 1767 1894137
SGTC_1292 0kpi-0043 232 µM 0.327372982768723 0.5 no 1674 0.371692899130712 1710 3333905
SGTC_2787 5284540 71.43 µM 0.326968781805584 0.499856073474834 no 1675 0.371845748550963 1713 736958
SGTC_2253 7938677 135.83 µM 0.325526449708851 0.49934249297603 no 1676 0.372391333887404 1864 2301972
SGTC_1962 st076595 64.5 µM 0.322681428748941 0.498329452003917 no 1677 0.373468259059946 1742 279619
SGTC_1129 3453-1384 223 µM 0.321796637696975 0.498014401878581 no 1678 0.373803380829826 1772 1084452
SGTC_3341 9147222 25.867 µM 0.321347170844777 0.497854359370173 no 1679 0.373973656603691 1769 1939759
SGTC_2054 5233173 129 µM 0.320941773240379 0.497710008977277 no 1680 0.374127258305396 1783 6889
SGTC_1524 corynanthine 62.1 µM 0.320926500811008 0.497704570911465 no 1681 0.374133045289685 1779 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_342 k048-0088 23.3 µM 0.320348198418957 0.497498654651674 no 1682 0.374352194801846 1701 6820570
SGTC_1346 1488-2224 62.4 µM 0.318932791056274 0.496994673164316 no 1683 0.374888739045772 1878 3722427
SGTC_2249 haloperidol 116.36 µM 0.317668259286036 0.496544417703253 no 1684 0.37536829519418 1799 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_712 r015-0009 80.6 µM 0.317482429555205 0.496478250603794 no 1685 0.37543878479865 1819 6813872 YLR060W FRS1
SGTC_2163 5671233 125 µM 0.316545969078181 0.496144813148164 no 1686 0.375794069609101 1859 701023
SGTC_1476 4112-3294 3.34 µM 0.316208901128871 0.496024796899474 no 1687 0.375921975998282 1839 704369
SGTC_3349 9149703 23.001 µM 0.315844207379644 0.495894944627578 no 1688 0.376060380840333 1727 4910494
SGTC_1308 1187-1617 41.4 µM 0.315799918466378 0.495879175217441 no 1689 0.376077190001744 1736 2882570
SGTC_3237 9133362 49.47 µM 0.314821828731387 0.495530920487359 no 1690 0.376448468472762 1808 43845137
SGTC_2582 agaric acid 100 µM 0.313962536052395 0.495224966964826 no 1691 0.37677474648018 1691 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_858 0438-0351 2.77 µM 0.313614835775628 0.495101168112688 no 1692 0.37690679515821 1723 2799119
SGTC_839 0122-0028 230 µM 0.31348190872092 0.495053839494416 no 1693 0.376957281643991 1782 759448
SGTC_318 1488-0629 67.2 µM 0.311374440522913 0.494303486129248 no 1694 0.377757991150295 1735 3662576
SGTC_3058 9093861 49.47 µM 0.31059244561969 0.494025065794503 no 1695 0.37805523543726 1797 17217477
SGTC_1699 st031318 29.054 µM 0.309180295859909 0.493522293501644 no 1696 0.378592190862947 1832 5340658
SGTC_1838 st055369 84.5 µM 0.309022932632804 0.493466267580321 no 1697 0.378652041150919 1737 676036
SGTC_918 glabranin 770.725 nM 0.307118535998594 0.492788257100673 no 1698 0.379376574688464 1799 124049 Also referred to as licorice root.
SGTC_11 0438-0307 1.3 µM 0.307096140741669 0.492780283976856 no 1699 0.379385097558988 1883 4011476
SGTC_694 1315-0438 43.2 µM 0.306672427365612 0.49262943476048 no 1700 0.379546359451488 1816 6793154
SGTC_196 k015-0023 18.111 µM 0.305145088382765 0.492085684835722 no 1701 0.380127826071986 1759 5211998
SGTC_2381 9035592 200 µM 0.304314275018052 0.491789912007225 no 1702 0.380444235340676 1707 4749657
SGTC_3003 9075612 71.4286 µM 0.304139989303075 0.491727866173937 no 1703 0.380510620955203 1783 6501993
SGTC_1153 4055-0057 267 µM 0.302904689720247 0.491288104504643 no 1704 0.380981248638742 1742 882706
SGTC_1946 st076057 65.1 µM 0.300863820775738 0.490561586844657 no 1705 0.381759169817672 1763 953009
SGTC_2626 ethyl orsellinate 100 µM 0.300662586084338 0.490489952075405 no 1706 0.381835900684161 1749 75653 A natural product.
SGTC_1493 4348-0038 111 µM 0.299164088764924 0.489956532433309 no 1707 0.382407424111192 1832 800424
SGTC_2823 7987624 58.44 µM 0.298728053551101 0.48980132044033 no 1708 0.382573775123621 1790 2239440
SGTC_2359 9039622 200 µM 0.297216363503078 0.489263228244717 no 1709 0.383150664890241 1847 6463596
SGTC_387 norethindrone acetate 66.7 µM 0.296915385331592 0.489156096146986 no 1710 0.383265554889064 1745 541197
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.295395629240447 0.488615156540233 no 1711 0.383845835890451 1762 75037 A free radical scavenger.
SGTC_2750 bromebric acid 70.15 µM 0.294717015510974 0.488373618534673 no 1712 0.384105031860522 1793 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1615 st002656 86.5 µM 0.293669503183886 0.488000787386287 no 1713 0.384505230093959 1772 1584458
SGTC_2830 7992007 71.43 µM 0.293048265473411 0.487779681060295 no 1714 0.384742629867883 1717 1952075
SGTC_1190 1486-1332 13 µM 0.292258058428113 0.487498441856028 no 1715 0.385044662027404 1759 4150046
SGTC_1628 st004252 77.7 µM 0.291631774727449 0.487275548316391 no 1716 0.385284089130442 1899 692968
SGTC_1264 0783-0040 158 µM 0.291571221477377 0.487253997704501 no 1717 0.385307240846237 1717 2855798
SGTC_2111 5486399 200 µM 0.290642964276781 0.48692364010557 no 1718 0.385662198541597 1754 689674
SGTC_1357 1503-1303 39.5 µM 0.290215181231583 0.486771399338034 no 1719 0.385825811413467 1790 292895
SGTC_3070 9117005 49.47 µM 0.289346761036944 0.486462349196749 no 1720 0.38615801587426 1865 8779016
SGTC_2335 9018011 154.17 µM 0.289344589570614 0.48646157643352 no 1721 0.386158846649222 1905 6458208
SGTC_997 3996-0078 137 µM 0.28834909337081 0.486107312993837 no 1722 0.386539765547157 1806 735687
SGTC_2133 5320837 200 µM 0.288342531239776 0.486104977789335 no 1723 0.386542276858882 1876 2841355
SGTC_3013 9080133 71.4286 µM 0.28781500623936 0.485917253942406 no 1724 0.386744174940987 1841 17050193
SGTC_2328 6201408 200 µM 0.286852846506864 0.485574870034419 no 1725 0.387112498400349 1770 2890418
SGTC_2341 7987486 176.74 µM 0.286777386418185 0.485548018057917 no 1726 0.387141389509351 1941 1258686
SGTC_519 k048-0011 62.8 µM 0.285921157937083 0.485243339401157 no 1727 0.387469254117658 1822 6836379
SGTC_1515 3460-0031 42.1 µM 0.285760486994109 0.485186167523752 no 1728 0.38753078673632 1858 2876596
SGTC_782 0083-0095 30.5 µM 0.285591642398072 0.485126087526465 no 1729 0.38759545268714 1790 3591729 An indicator and reagent.
SGTC_397 arbidol 50 µM 0.285187359966748 0.48498223302454 no 1730 0.387750301865133 1904 131410 A RNA synthesis inhibitor.
SGTC_3025 9087895 49.47 µM 0.284561178039278 0.484759424611835 no 1731 0.387990178729143 1910 17173641
SGTC_1120 ficusin 1.78878 µM 0.282152922216401 0.483902562598731 no 1732 0.388913127449273 1888 6199 A DNA cross-linker.
SGTC_2502 avocadyne acetate 18.59 µM 0.280899100781018 0.483456479716906 no 1733 0.389393895184212 1774 3952079
SGTC_3087 9117406 49.47 µM 0.280783843792087 0.483415474773189 no 1734 0.389438098058739 1811 42546093
SGTC_1223 0764-0573 147 µM 0.280400933849978 0.483279248281947 no 1735 0.389584960333361 1804 1609797
SGTC_589 1227-0070 34.1 µM 0.279550894219514 0.482976839742961 no 1736 0.389911043074162 1842 2841384
SGTC_2832 7992762 51.95 µM 0.278826445056814 0.482719118761222 no 1737 0.390189009373377 1616 2985177
SGTC_1527 coumarin 137 µM 0.278496732417121 0.482601826696962 no 1738 0.390315536510566 1879 323 A hepatotoxic, DNA x-linker.
SGTC_257 daunorubicin 18.5 µM 0.278406568098654 0.482569751879515 no 1739 0.390350139067256 1942 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1845 st056753 3.01 µM 0.278279057316947 0.482524391722119 no 1740 0.390399075640152 1728 5375839
SGTC_1901 st060216 58.6 µM 0.277825239894556 0.482362954431073 no 1741 0.390573257499842 1765 688792
SGTC_2814 7977482 42.97 µM 0.277689095916254 0.482314524250557 no 1742 0.390625515862748 1912 6456762
SGTC_2557 derrustone 83.84 µM 0.277519957100103 0.482254357256759 no 1743 0.390690441924065 1750 629853 An antioxidant.
SGTC_714 4296-0578 26.1 µM 0.27749330003827 0.482244874696337 no 1744 0.39070067485049 1945 1589775
SGTC_972 1319-0219 195 µM 0.277266557944656 0.482164217466475 no 1745 0.390787718078803 1781 23903702
SGTC_2695 st077686 51.995 µM 0.277217894715319 0.482146906963327 no 1746 0.39080639994892 1771 2876092
SGTC_2136 5328288 199.296 µM 0.276086118545227 0.481744320659908 no 1747 0.391240961137793 1782 262395
SGTC_1643 st009866 20.2 µM 0.275977252615436 0.481705596723158 no 1748 0.391282768892593 1909 3156273 YOR207C RET1
SGTC_1717 st033143 58.0435 µM 0.275543644077706 0.481551362586223 no 1749 0.391449299927417 1927 674616
SGTC_170 4197-0004 226 µM 0.272892064172529 0.480608259109713 no 1750 0.392468093477381 1881 218692
SGTC_209 4077-0173 175.592 µM 0.272203058433792 0.480363213819471 no 1751 0.392732945154938 1851 15993494
SGTC_1834 st055981 52.8 µM 0.272140372307966 0.480340919829376 no 1752 0.392757043975255 1932 471719 YDL150W RPC53
SGTC_3012 9080433 71.4286 µM 0.27192518508177 0.480264390095387 no 1753 0.392839772876952 1964 17688859
SGTC_1444 4112-3581 28 µM 0.271058238780411 0.479956074499263 no 1754 0.393173120081028 1838 2877249
SGTC_3312 9133330 71.43 µM 0.27054031936598 0.479771890447049 no 1755 0.393372301286613 1895 17617324
SGTC_2446 5162541 200 µM 0.269637830250415 0.479450954909861 no 1756 0.393719446790282 1784 1549321
SGTC_1848 st056003 16.4 µM 0.268970069850855 0.47921350017442 no 1757 0.393976357493625 2018 146492
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.267667971987491 0.478750497150872 no 1758 0.394477452560117 1844 364106
SGTC_2929 9013348 24.6 µM 0.267113452141964 0.478553328348467 no 1759 0.394690905237084 1836 2995952
SGTC_3268 9137683 49.47 µM 0.265999405834856 0.478157226471004 no 1760 0.395119833309619 1821 1953228
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.265370020541574 0.477933456509679 no 1761 0.395362214313949 1827 390807
SGTC_1596 piperlongumine 63 µM 0.263991312029289 0.477443298585763 no 1762 0.395893306675436 1969 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2685 mycophenolic acid 18.85 µM 0.262238506386097 0.476820191154145 no 1763 0.396568784026521 1911 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2540 epiandrosterone 100 µM 0.261681022273821 0.476622022120853 no 1764 0.396783686432725 1914 441302 A steroid.
SGTC_1559 coumarin 343 70.1 µM 0.261506799340041 0.4765600922293 no 1765 0.396850853394494 1908 108770 A hepatotoxic, DNA x-linker.
SGTC_2008 4012253 172 µM 0.25966013106932 0.475903704183636 no 1766 0.397562974381737 1821 603940
SGTC_112 phenothiazine 287.218 µM 0.259328237651979 0.475785741380046 no 1767 0.397690996971634 1986 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2216 7189485 200 µM 0.258495570206277 0.47548980095663 no 1768 0.398012233625337 1936 731273
SGTC_33 0986-0033 35.816 µM 0.257441866725474 0.475115320964009 no 1769 0.398418843365384 1914 2848082
SGTC_2061 5245884 80.95 µM 0.255916758586036 0.474573345561176 no 1770 0.399007556978106 1833 573863
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.255308364792681 0.474357154639619 no 1771 0.399242469904684 1949 23847180
SGTC_1923 st058458 19.1 µM 0.255129234286561 0.474293502584126 no 1772 0.399311642708185 1976 3534982
SGTC_911 3456-4043 236 µM 0.254501899671601 0.474070591311248 no 1773 0.399553918336817 1910 914281
SGTC_639 0833-0042 114 µM 0.254339368091427 0.474012840165871 no 1774 0.399616694087214 1811 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1702 st027038 51 µM 0.254298405762214 0.473998285410232 no 1775 0.399632515674054 1885 5521182
SGTC_2552 juarezic acid 87.02 µM 0.253611436867206 0.473754196460323 no 1776 0.399897880057141 1977 1549512
SGTC_3006 9075424 71.4286 µM 0.253156840193013 0.473592677783274 no 1777 0.400073508438537 1808 7465181
SGTC_3210 9128157 49.47 µM 0.252947187242366 0.473518189330244 no 1778 0.400154512342609 1731 17590849
SGTC_2596 sinensetin 100 µM 0.252906810055884 0.473503843661018 no 1779 0.400170113426122 1820 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1176 0848-0131 83.3 µM 0.251873613655708 0.47313676955265 no 1780 0.400569377721764 1995 6769040
SGTC_1910 st062352 60.4 µM 0.250947428382135 0.472807733746639 no 1781 0.400927377405277 1815 2245730
SGTC_3253 9135987 49.47 µM 0.249572812841576 0.472319423248801 no 1782 0.401458862786765 1906 4182430
SGTC_2587 piperic acid 92.2 µM 0.249322908958189 0.472230653281931 no 1783 0.401555505974971 1819 5370536
SGTC_2057 5236571 38.335 µM 0.249306314955374 0.472224758868176 no 1784 0.401561923444802 1963 54684039 YBR257W POP4
SGTC_3086 9117350 49.47 µM 0.248632412141595 0.471985384647819 no 1785 0.401822567182278 1873 2679265
SGTC_1942 st076330 65.2 µM 0.248197938589615 0.471831062460838 no 1786 0.401990630614785 1925 24208414
SGTC_1651 st011928 86.1 µM 0.244614664761919 0.470558470238369 no 1787 0.403377404066481 1904 720198
SGTC_1935 st074532 41.6 µM 0.24137043434146 0.469406547508828 no 1788 0.404634012695653 2027 2829742
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.241165592511696 0.469333823201772 no 1789 0.404713388568782 1981 6728940
SGTC_1092 toremifene 6.32 µM 0.240862800985691 0.469226326017478 no 1790 0.404830726969906 1981 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1770 st043884 66.3 µM 0.240674902295835 0.469159619267194 no 1791 0.40490354616427 1889 670149
SGTC_1802 st050112 57.9 µM 0.239779276129459 0.468841670964811 no 1792 0.405250686807242 1969 4662563
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.238108166442214 0.468248478417544 no 1793 0.405898600485057 1812 23665772 A membrane-active detergent.
SGTC_282 k297-0036 65.7 µM 0.237777696520536 0.468131180064862 no 1794 0.406026759101766 1936 5061378
SGTC_1570 verbenone 133 µM 0.232688369175725 0.466325108835783 no 1795 0.408001700699121 2020 29025 A natural terpanoid with antifungal properties.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.232665745418273 0.466317081766995 no 1796 0.408010485233594 1942 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_18 0111-0177 500 nM 0.228657243252329 0.464895056206416 no 1797 0.409567664648344 1898 721752
SGTC_2456 5770359 74.46 µM 0.22844006900178 0.464818025767481 no 1798 0.409652071134603 1994 3118787
SGTC_3176 9106582 49.47 µM 0.227990727370757 0.464658651103351 no 1799 0.409826724596704 2015 17018027
SGTC_2254 7938975 95.19 µM 0.227745603719473 0.464571711848997 no 1800 0.409922008633926 1993 2969277
SGTC_796 1234-0020 70.7 µM 0.226171355125315 0.464013405569075 no 1801 0.41053407434483 1890 46495034
SGTC_2621 lithochol-11-enic acid 100 µM 0.225929495074408 0.463927636305032 no 1802 0.410628128555376 2039 6708711
SGTC_934 2950-0684 338 µM 0.225913739146682 0.463922048940506 no 1803 0.41063425587768 2017 1121253
SGTC_1436 4092-1007 8.32 µM 0.224802447908586 0.463527981036469 no 1804 0.411066480831255 1921 2881121
SGTC_2343 7990716 14.84 µM 0.223765731828489 0.463160390007264 no 1805 0.411469797942411 1950 6456862
SGTC_2796 7949634 45.45 µM 0.223732371999034 0.463148562049257 no 1806 0.411482777584188 1878 2971588
SGTC_177 1327-0068 8.361 µM 0.223509019258525 0.463069371631789 no 1807 0.411569682158945 1977 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2406 ethylparaben 405.7 µM 0.221222636512141 0.462258812151567 no 1808 0.412459542241717 1657 8434 A possible steroid mimic.
SGTC_2846 9008642 19.48 µM 0.219612091733065 0.4616879419789 no 1809 0.413086636730823 1878 2992898
SGTC_2248 tofa 1.1 µM 0.219134055942322 0.461518513596998 no 1810 0.413272811302452 1905 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1860 st056228 74.6 µM 0.218944968756974 0.461451498080906 no 1811 0.413346458089564 1884 688679
SGTC_2483 5729050 27.16 µM 0.215692191044858 0.460298834718492 no 1812 0.414613844298081 2036 2865180
SGTC_2060 5238662 140 µM 0.215004938210122 0.46005534024705 no 1813 0.414881734230889 1905 790130
SGTC_1799 st045822 46.1415 µM 0.213744766920637 0.459608899088314 no 1814 0.41537304951573 2036 3674992
SGTC_1210 3013-0140 750 nM 0.212629426803511 0.459213809764126 no 1815 0.415808008493796 2054 905973
SGTC_799 1310-0557 151 µM 0.212285895910086 0.45909212817383 no 1816 0.415941999057583 1944 5354492
SGTC_2045 5106652 78.05 µM 0.212125301011786 0.459035245396674 no 1817 0.4160046407389 2011 673349
SGTC_3148 9097893 49.47 µM 0.212058968201936 0.459011750533605 no 1818 0.416030515152128 1828 17174100
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.211052231868423 0.458655185458285 no 1819 0.416423257017633 1877 2374 Ca(2+)-ATPase inhibitor.
SGTC_1315 1237-0019 3.69 µM 0.209553120844129 0.458124293235142 no 1820 0.41700823565567 2037 825140
SGTC_2043 5101342 149 µM 0.208988410284932 0.457924327068688 no 1821 0.417228643053614 1955 678451
SGTC_1465 k213-0056 144 µM 0.2089211081752 0.457900495843765 no 1822 0.417254912906543 1912 24048857 YMR208W ERG12
SGTC_3224 9130643 49.47 µM 0.208829923373932 0.457868208159669 no 1823 0.41729050541597 1973 17644395
SGTC_376 3970-0862 59.1 µM 0.208441561222526 0.457730695875635 no 1824 0.417442103875009 2036 3135186
SGTC_2740 felodipine 17.08 µM 0.207920779787888 0.457546304170934 no 1825 0.417645411901036 2064 3333 L-type calcium channel blocker
SGTC_1459 k035-0031 35.7 µM 0.206934791946014 0.457197223124467 no 1826 0.418030392256658 1844 3877128 YMR208W ERG12
SGTC_2743 auranofin 4.32 µM 0.204691315150509 0.456403061726603 no 1827 0.418906653125276 2007 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3064 1327-0027 10 µM 0.204499973624426 0.456335337346483 no 1828 0.418981406301486 1967 16000455 YPR107C YTH1
SGTC_2081 5214970 32.255 µM 0.204497180598534 0.456334348778268 no 1829 0.418982497500593 2036 2063512
SGTC_3163 9099914 49.47 µM 0.204189162056255 0.456225329844589 no 1830 0.419102840185499 2059 16268368
SGTC_2855 9016525 58.44 µM 0.204178806339587 0.456221664638079 no 1831 0.419106886290213 1987 43811474
SGTC_2882 9058044 58.44 µM 0.203719105823001 0.456058966249416 no 1832 0.41928650549779 1851 18076804
SGTC_304 1310-0298 97 µM 0.202733637161857 0.455710211507977 no 1833 0.419671615215633 1956 1550234
SGTC_2014 4013930 200 µM 0.202347579255374 0.455573595928254 no 1834 0.419822503162387 2097 64556
SGTC_137 0438-0332 85.389 µM 0.201020783845982 0.455104118626514 no 1835 0.420341161308972 2022 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_162 k030-0015 37.8 µM 0.200512258017126 0.454924196893142 no 1836 0.420539986075563 2041 1809920 YMR134W ERG29
SGTC_2812 7970281 58.44 µM 0.198844999389433 0.454334368479754 no 1837 0.421191997180904 2026 2233435
SGTC_740 k014-0057 261 µM 0.197375809132071 0.453814694400014 no 1838 0.421766729383055 2047 4012779
SGTC_762 1165-0429 115 µM 0.195825239082592 0.453266320869377 no 1839 0.422373477295233 2074 5967793
SGTC_2894 9048625 32.47 µM 0.195115666330438 0.453015403515309 no 1840 0.422651199160731 2069 4092861
SGTC_2744 captopril 92.04 µM 0.192073486208974 0.451939849184324 no 1841 0.423842321576675 2079 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1600 coumarin 106 71.1 µM 0.191958904372546 0.451899345936132 no 1842 0.423887198138629 1996 100336 A hepatotoxic, DNA x-linker.
SGTC_92 0063-0024 660.874 µM 0.191672557767849 0.451798128177324 no 1843 0.423999351564503 2101 3594437
SGTC_125 0133-0007 11.75 µM 0.19022026915812 0.451284821776934 no 1844 0.424568264300393 2094 26541
SGTC_378 3970-0959 8.33 µM 0.189813943146286 0.451141221794138 no 1845 0.424727464739568 1990 6615653
SGTC_2353 9059630 146.67 µM 0.188198876130372 0.450570503139827 no 1846 0.425360376732812 2042 4779114
SGTC_542 3381-0244 89.3 µM 0.187628397722347 0.450368936691125 no 1847 0.425583981711565 2072 1112843
SGTC_219 mitoxanthrone 164.414 µM 0.185228690239819 0.449521191716777 no 1848 0.426524833441625 2050 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1007 4101-0031 70 µM 0.18463005376385 0.449309747078958 no 1849 0.426759605844182 2078 1146276
SGTC_2638 epoxomicin 18 µM 0.184052708687053 0.449105836419117 no 1850 0.426986052798921 2094 9915668 A protesome inhibitor.
SGTC_408 cantharidin 100 µM 0.182261940044904 0.448473446313276 no 1851 0.427688582901272 1991 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.181954421988567 0.448364862844214 no 1852 0.427809247353768 2104 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_547 1120-0019 610 nM 0.181271137737893 0.448123611603178 no 1853 0.428077379729988 1960 3676939
SGTC_1054 3429-0080 167 µM 0.180399423489135 0.447815858123354 no 1854 0.428419503444721 2052 1162877
SGTC_1455 4262-0120 131 µM 0.180049857531296 0.447692454774459 no 1855 0.42855671353622 2056 1529587
SGTC_1697 st025554 27.742 µM 0.178311882496014 0.447078992333206 no 1856 0.429239023737187 1981 1269519
SGTC_3260 9137109 49.47 µM 0.177268468208562 0.44671075347636 no 1857 0.429648758624115 2103 17478346
SGTC_855 0428-0020 25 µM 0.176294357135129 0.446367014377141 no 1858 0.430031347480336 1974 6812414
SGTC_3291 9121177 71.43 µM 0.17561748857378 0.446128188337655 no 1859 0.43029723099825 1955 17015612
SGTC_1679 SEC14.276 6.7 µM 0.174633312105671 0.445780966784618 no 1860 0.430683885754917 2110 1005053 YMR079W SEC14
SGTC_2206 7254556 146.969 µM 0.174010916085618 0.44556140432404 no 1861 0.430928441659099 2097 4398905
SGTC_1085 doxorubicin 7.67 µM 0.172706118312842 0.445101165464493 no 1862 0.431441217172971 2113 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_46 0329-0187a 2.197 µM 0.171828506762782 0.444791648776362 no 1863 0.431786176836195 2027 46494817
SGTC_2316 5844804 197.44 µM 0.171685925346212 0.444741366230696 no 1864 0.431842225727914 2122 776813
SGTC_1779 st039427 55 µM 0.171657611377821 0.444731381175432 no 1865 0.431853356139387 2154 1124498
SGTC_701 4424-0219 185 µM 0.171603496867412 0.444712297534209 no 1866 0.431874629068008 2123 2911779
SGTC_1243 0416-0003 5.65 µM 0.171501737702915 0.444676412212722 no 1867 0.431914632098165 1973 2141977
SGTC_3240 9133527 49.47 µM 0.171387419953595 0.444636098653055 no 1868 0.431959572926129 1998 17617455
SGTC_2037 5169046 200 µM 0.170396101955587 0.444286539576487 no 1869 0.432349318752304 2027 5718022
SGTC_2976 9009005 19.48 µM 0.168292063128135 0.443544756213139 no 1870 0.433176758759927 2126 2993148
SGTC_2453 5731132 22.18 µM 0.16785788063651 0.443391708784195 no 1871 0.433347543134671 2098 1362040
SGTC_2326 6164455 177.58 µM 0.166408834824233 0.442880987718754 no 1872 0.433917610854459 1989 2888790
SGTC_541 4513-1321 94 µM 0.166009067817767 0.442740105158952 no 1873 0.434074907053519 1937 747515
SGTC_1399 3562-5772 25 µM 0.165178186892923 0.442447316202733 no 1874 0.434401866879588 2034 23847490
SGTC_1418 3966-3099 2.4 µM 0.164777076272009 0.442305982568161 no 1875 0.4345597239337 2082 740335
SGTC_742 0kpi-0133 140 µM 0.162545245389048 0.44151971870805 no 1876 0.435438250658734 2108 2728852
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.15948326420298 0.440441372161454 no 1877 0.436644071395006 2051 5393153
SGTC_3125 9127534 49.47 µM 0.159191669082564 0.440338703187903 no 1878 0.436758933637088 2153 1639235
SGTC_1421 4029-0249 71.4 µM 0.158640270156223 0.440144569749917 no 1879 0.436976149770243 2151 2894095
SGTC_3181 9108277 49.47 µM 0.158325215795593 0.440033653635945 no 1880 0.437100269699574 2024 17097298
SGTC_3103 9120822 49.47 µM 0.15711363725401 0.43960715661644 no 1881 0.437577645043782 2114 17141819
SGTC_2315 7733312 200 µM 0.15679432332222 0.439494764128821 no 1882 0.437703473424127 2009 726316
SGTC_2174 5790901 200 µM 0.156311158583853 0.439324708519966 no 1883 0.437893880587742 2017 786020
SGTC_2703 st077852 53.4 µM 0.154298409493028 0.438616418226621 no 1884 0.438687225670088 2044 6281836
SGTC_2678 equilin 100 µM 0.152243349511168 0.437893441441081 no 1885 0.43949750223574 2132 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_329 k048-0121 21.3 µM 0.151436992645905 0.437609818958428 no 1886 0.439815505016395 2038 6832902
SGTC_1572 epiandrosterone 68.9 µM 0.151016092244326 0.4374617870351 no 1887 0.439981510854307 2056 441302 A steroid.
SGTC_887 0885-0007 9.62 µM 0.150979225526409 0.437448821317381 no 1888 0.439996051829083 2122 5719458
SGTC_2162 5663267 200 µM 0.150511886725077 0.437284467979532 no 1889 0.440180386657916 2126 6456493
SGTC_384 k007-0144 5.16 µM 0.148720081484249 0.436654427867082 no 1890 0.440887257362144 2044 6824886
SGTC_2838 9002687 71.43 µM 0.147562344200078 0.436247426030899 no 1891 0.441344087332147 1957 6457060
SGTC_1126 isoteolin 1.0172 µM 0.147531310339752 0.436236517023169 no 1892 0.441356334017422 2082 133323
SGTC_1105 epirubicin 18.1 µM 0.147131895713716 0.436096119317179 no 1893 0.441513957347507 2000 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1102 cgs 12066b 26.1 µM 0.147019958376904 0.436056773815953 no 1894 0.441558133496332 2053 6438352 A 5-HT1B full agonist.
SGTC_1397 3532-0190 20.1 µM 0.145748964319155 0.435610069247571 no 1895 0.442059783057999 2058 5322280
SGTC_2946 9065502 71.43 µM 0.14515719292631 0.435402112801573 no 1896 0.442293381493372 2170 16489101
SGTC_25 0118-0223 35.662 µM 0.144966441023476 0.43533508381544 no 1897 0.442368684016776 2137 5333628
SGTC_2338 7999974 200 µM 0.144866472942677 0.435299956419655 no 1898 0.442408148930604 2161 315925
SGTC_1728 st035614 33.7865 µM 0.144303283807017 0.435102069124142 no 1899 0.442630492673242 2020 15945546
SGTC_492 tmb-8 126 µM 0.142838185325105 0.434587354954674 no 1900 0.443208989374063 2152 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1178 0988-0033 191 µM 0.142601828902884 0.434504329260052 no 1901 0.443302326494862 2095 5392207
SGTC_706 4262-0057 46.9 µM 0.142390622306515 0.434430140470854 no 1902 0.443385734614465 2105 883298
SGTC_2294 7971431 200 µM 0.14158609421554 0.434147561733814 no 1903 0.443703475738716 2113 5741572
SGTC_3042 9091578 49.47 µM 0.141497230324354 0.434116351651283 no 1904 0.443738573955736 2150 25236497
SGTC_2466 5983409 37.09 µM 0.141163677834757 0.43399920761368 no 1905 0.443870319788453 2040 2879657
SGTC_2182 6325192 200 µM 0.141004982814381 0.433943475764887 no 1906 0.443933002979172 2182 736248
SGTC_1289 0976-0073 69.1 µM 0.140699913067001 0.433836342500658 no 1907 0.444053506887583 2091 3391136
SGTC_71 0417-1750 47.813 µM 0.138556113006341 0.433083628254299 no 1908 0.4449004627227 2178 6811472
SGTC_516 3992-2719 87.3 µM 0.137561813857732 0.432734599963961 no 1909 0.445293368332113 2091 5350887 YDR037W KRS1
SGTC_321 4534-3890 65.3 µM 0.134281990340024 0.431583658765498 no 1910 0.446589796941655 2167 699746
SGTC_2617 dihydrotanshinone i 20.83 µM 0.13371053780487 0.431383186278653 no 1911 0.446815736016077 2084 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_952 1185-0122 232 µM 0.133137220674288 0.43118207742947 no 1912 0.447042429657272 2153 678600
SGTC_60 0986-0278 202 µM 0.132410445455346 0.430927164022627 no 1913 0.447329826572332 1888 3110598
SGTC_3122 9126309 49.47 µM 0.13146063199992 0.430594064264553 no 1914 0.447705463680417 2202 17591206
SGTC_1147 3809-1045 12.3 µM 0.130671852563497 0.430317476685415 no 1915 0.448017449892531 2030 325925
SGTC_2210 7115885 190.385 µM 0.130244186462678 0.430167528728442 no 1916 0.448186618274974 2131 2927039
SGTC_2597 laccaic acid a 100 µM 0.130036397571609 0.430094677582201 no 1917 0.448268815030824 2086 5491415 A textile dye.
SGTC_1934 st074720 32.6 µM 0.130014713424853 0.430087075219759 no 1918 0.448277392934643 2149 17250992
SGTC_1198 1612-1005 86.7 µM 0.129669845084687 0.429966169446645 no 1919 0.448413820617003 2159 6998509
SGTC_623 k072-0108 16.9 µM 0.128628454113726 0.429601112973834 no 1920 0.448825825104608 2093 5382803
SGTC_559 1550-0661 158 µM 0.128577845754615 0.429583373896799 no 1921 0.448845848649867 2096 5830875
SGTC_2919 7978188 46.38 µM 0.128060989608456 0.429402215312376 no 1922 0.449050353789508 2186 2980291
SGTC_3131 9127911 49.47 µM 0.127273972914862 0.429126393758106 no 1923 0.449361779683182 2110 45595681
SGTC_2100 5377183 190 µM 0.126831156245266 0.428971217358314 no 1924 0.449537017872039 2134 2844202
SGTC_757 1066-0008 322 µM 0.125899365763982 0.428644725576514 no 1925 0.449905792364443 2142 6842497
SGTC_2048 5246248 200 µM 0.124947260002527 0.428311165921399 no 1926 0.450282651717301 2206 677046
SGTC_1442 4112-3290 3 µM 0.123513752205518 0.427809049091614 no 1927 0.450850142494516 2190 704353
SGTC_2190 6049624 200 µM 0.123361817415403 0.427755837511738 no 1928 0.450910295682338 2164 2265554
SGTC_3316 9136639 10.545 µM 0.122269699441759 0.427373387651984 no 1929 0.451342714129679 2127 4903665
SGTC_451 chloral hydrate 100 µM 0.12086455913082 0.426881420626269 no 1930 0.451899157021121 2087 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_281 1672-3440 14.9 µM 0.120612249473773 0.426793094115636 no 1931 0.451999083001331 2154 6833000
SGTC_807 1315-0151 48 µM 0.120071329551413 0.426603745648953 no 1932 0.452213321876522 2217 4011080
SGTC_1353 1498-1206 8.11 µM 0.119795699364181 0.426507268085751 no 1933 0.45232249440988 2162 6756808
SGTC_3270 9137563 49.47 µM 0.118192839910557 0.425946313901659 no 1934 0.452957431558114 2169 17015724
SGTC_885 0865-0106 16.8 µM 0.11813455816815 0.425925919803172 no 1935 0.452980520851373 2164 2793380
SGTC_1530 rhein 70.4 µM 0.117876466220215 0.425835609981337 no 1936 0.453082770230457 2197 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2364 9055074 200 µM 0.117576508537679 0.425730655667389 no 1937 0.453201609642924 2086 6470630
SGTC_1311 1190-0148 100 µM 0.116553692485629 0.425372814931678 no 1938 0.453606867781165 2189 1961333
SGTC_2204 7233102 200 µM 0.11618422500946 0.425243568746698 no 1939 0.45375326934878 2148 2172480
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.115482906494808 0.424998257373733 no 1940 0.454031184232952 2184 6312947
SGTC_1184 1269-1718 139 µM 0.115320340720124 0.424941398289881 no 1941 0.454095608178256 2190 5403821
SGTC_2645 abamectin 100 µM 0.114528893148822 0.424664603532448 no 1942 0.454409271831791 2167 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_756 0508-1999 28.3 µM 0.114153051924455 0.424533172726225 no 1943 0.454558233842324 2014 6753853
SGTC_1892 st058411 7.36 µM 0.113258820141436 0.424220495698339 no 1944 0.454912681938349 2199 3934738
SGTC_602 3130-1533 38.1 µM 0.113170718837434 0.424189692779604 no 1945 0.454947604741759 2189 720941
SGTC_1426 4048-4480 71.7 µM 0.110555642824024 0.42327559365166 no 1946 0.455984361838317 2205 14224343
SGTC_787 4152-0075 138 µM 0.110468773102083 0.423245235420989 no 1947 0.456018806862112 2071 9566539
SGTC_2432 5630864 12.22 µM 0.110292803570233 0.423183741010843 no 1948 0.45608858218255 2115 5714970
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.108891267285289 0.422694026292071 no 1949 0.456644366576937 2216 165521
SGTC_1989 st071868 50.2 µM 0.108691019544633 0.422624066903308 no 1950 0.456723782509647 2241 16414057
SGTC_2813 7971799 71.43 µM 0.108441045129655 0.422536738220598 no 1951 0.45682292189027 2126 2234054
SGTC_870 0573-2213 57.6 µM 0.105642421343875 0.421559298539638 no 1952 0.457933032844546 2217 3916321
SGTC_1705 st027868 56.3335 µM 0.105497709346476 0.421508769908727 no 1953 0.457990443762243 2213 292948
SGTC_1235 benzylparaben 21.5 µM 0.104806311299482 0.42126737448999 no 1954 0.458264750970746 2162 7180
SGTC_1468 k284-1086 134 µM 0.104319954304619 0.421097585036808 no 1955 0.458457721531873 2104 15996457
SGTC_1979 st071809 45.3 µM 0.104204412451085 0.421057251002676 no 1956 0.458503566204353 2183 4976333
SGTC_474 dl-dihydrosphingosine 5 µM 0.103992589226833 0.420983308649865 no 1957 0.458587614812085 2198 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1568 digitonin 820 nM 0.10282353906478 0.420575271785376 no 1958 0.459051511405037 2239 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1453 4237-0541 195 µM 0.102499591989223 0.420462218706158 no 1959 0.459180068345078 2237 739892
SGTC_68 0986-0284 82.829 µM 0.10087203389959 0.419894322758632 no 1960 0.459826021781465 1934 423278 YIL048W NEO1
SGTC_8 0354-0001 70 µM 0.0999376707628659 0.419568375234435 no 1961 0.460196904549525 2171 4993152
SGTC_644 1498-1197 63.3 µM 0.0991612525601979 0.419297567910477 no 1962 0.460505119579992 2194 6741615
SGTC_2839 9003951 25.97 µM 0.0985656327188938 0.419089847246617 no 1963 0.460741579110613 2297 2990634
SGTC_638 3970-0837 4.09 µM 0.0966615820500508 0.418425966735742 no 1964 0.461497574997687 2136 4118451 YLR208W SEC13
SGTC_2280 7785178 200 µM 0.0958146426560079 0.418130741060977 no 1965 0.461833893854465 2161 2954328
SGTC_1727 st034309 9.9045 µM 0.0941791648497889 0.417560777758096 no 1966 0.462483417620909 2247 870305
SGTC_266 formosanin C 406 nM 0.0934401108452049 0.417303274489356 no 1967 0.462776963022147 2232 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1157 4092-0394 27.6 µM 0.0909723320167658 0.416443701588571 no 1968 0.463757287862878 2214 3659885
SGTC_6 0844-0013 19.835 µM 0.0898093949726789 0.416038767369778 no 1969 0.464219341127356 2250 1584900
SGTC_790 1575-0012 79.1 µM 0.0893179377382576 0.415867668917898 no 1970 0.464414619395432 2267 378741 YLR208W SEC13
SGTC_1741 st038134 10.228 µM 0.0880539484966091 0.415427690517492 no 1971 0.4649168989598 2199 1272587
SGTC_3307 9126885 69.2785 µM 0.0874872516505491 0.415230465021349 no 1972 0.465142109142638 2190 24824909
SGTC_2994 9053520 71.4286 µM 0.0854708375800281 0.414528873109125 no 1973 0.465943539426588 2228 4647384
SGTC_179 1273-0063 6.77 µM 0.0846696006320887 0.414250165960301 no 1974 0.466262032168889 2207 3108139
SGTC_2200 6600604 21.907 µM 0.0839784054798729 0.414009771102718 no 1975 0.46653680051975 2243 2904777
SGTC_910 3454-3003 490 µM 0.082858210051694 0.413620240150101 no 1976 0.466982141637989 2263 820824
SGTC_976 1348-1067 47.6 µM 0.0826664110571372 0.413553553473088 no 1977 0.467058396759878 2255 5310671 YGL099W LSG1
SGTC_50 0929-0078 56.389 µM 0.0826445539762751 0.413545954133229 no 1978 0.467067086738144 2194 1377751
SGTC_2742 clothiapine 36.27 µM 0.082417800606784 0.413467117706816 no 1979 0.467157240683756 2262 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1169 aniline yellow 25.8 µM 0.0821427515721688 0.41337149477824 no 1980 0.467266598566435 2228 6051 A DNA damaging agent.
SGTC_1707 st032323 6.317 µM 0.0813694489394019 0.413102677672528 no 1981 0.467574072368868 2188 3132057 YMR211W DML1
SGTC_2667 digitoxin 100 µM 0.0806759934369345 0.412861651836629 no 1982 0.467849814516191 2280 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2995 9067767 71.4286 µM 0.0806347223393897 0.412847308186294 no 1983 0.467866225834884 2182 11673567
SGTC_1115 galangin 695.678 nM 0.0803050061741685 0.412732720468392 no 1984 0.467997338362214 2248 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2005 4024620 188 µM 0.0800996915422177 0.412661370322181 no 1985 0.468078984037313 2248 236743
SGTC_1181 1222-0449 220 µM 0.0784360620494109 0.412083338861443 no 1986 0.468740594256704 2234 658318
SGTC_2766 oltipraz 83.91 µM 0.0783883716506186 0.412066771540649 no 1987 0.468759561573385 2256 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_578 3460-0051 92 µM 0.0779399534020499 0.411911001753682 no 1988 0.468937908918836 2271 2876744
SGTC_1739 st037196 92.5 µM 0.0775560953554468 0.411777669663435 no 1989 0.469090583982635 2263 612214
SGTC_2821 7996764 71.43 µM 0.0770056504236752 0.411586491832256 no 1990 0.469309524964793 2203 2987135
SGTC_3060 1327-0027 12.5 µM 0.0722199510587038 0.409925235438547 no 1991 0.471213433990871 2284 16000455 YPR107C YTH1
SGTC_2522 biochanin a 4.94 µM 0.0721040799060595 0.409885033079996 no 1992 0.471259539691889 2253 5280373 A possible chelator.
SGTC_2651 TUB2.036 5 µM 0.0714780506499457 0.409667843966942 no 1993 0.471508646456234 2272 15992207 YFL037W TUB2
SGTC_968 1309-0633 340 µM 0.0706375370164833 0.409376287118732 no 1994 0.471843117398237 2276 3761976
SGTC_770 0389-1121 67.2 µM 0.0705950406383637 0.409361547331134 no 1995 0.471860028781959 2260 6753108
SGTC_1091 telmisartan 47.6 µM 0.0703930525801853 0.409291489911119 no 1996 0.471940410385436 2254 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1021 4476-0760 85.3 µM 0.0689033595724185 0.408774895269372 no 1997 0.472533272162651 2236 746768
SGTC_716 1683-5115 658 µM 0.0682442757049961 0.408546389156091 no 1998 0.472795591093199 2302 723597
SGTC_1183 1254-0324 198 µM 0.0672165391066168 0.408190132231689 no 1999 0.473204659299156 2255 5799357
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0664682519540372 0.407930792008652 no 2000 0.473502516532443 2268 165506
SGTC_81 0411-0046 9.971 µM 0.06505718704874 0.40744185710618 no 2001 0.474064233983223 2284 12925265
SGTC_2529 gangaleoidin 93.61 µM 0.0649783300170651 0.407414537339985 no 2002 0.47409562696317 2262 4565183
SGTC_587 k089-0003 57 µM 0.0644860286756924 0.407243991302738 no 2003 0.474291615729057 2298 9659696
SGTC_1550 gossypolone 36.6 µM 0.0641761954018798 0.407136665980925 no 2004 0.474414965815432 2286 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_597 k018-0003 82.8 µM 0.0639114000405855 0.407044947182908 no 2005 0.474520387459425 2258 6786234
SGTC_74 000s-0487 160.283 µM 0.0635790330648825 0.406929830404167 no 2006 0.474652713574284 2302 677548
SGTC_2958 9077254 16.72 µM 0.0629967382090294 0.406728169382035 no 2007 0.474884550847986 2223 16457351
SGTC_1440 4100-1550 40 µM 0.0624163226081325 0.406527183796186 no 2008 0.4751156483709 2275 742806
SGTC_2421 5690543 90.72 µM 0.0623904165905419 0.406518213666553 no 2009 0.475125963273022 2218 3397993
SGTC_503 tyrphostin 8 294 µM 0.0623888501150917 0.406517671265659 no 2010 0.475126586991227 2292 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1412 3909-8563 178 µM 0.0614445690335812 0.406190741333183 no 2011 0.475502579217355 2296 23767530
SGTC_3201 9113999 49.47 µM 0.0605981593705946 0.405897752113113 no 2012 0.475839619720742 2268 16649224
SGTC_2859 9028643 45.46 µM 0.0599722106315511 0.40568111050649 no 2013 0.476088883771649 2263 17151580
SGTC_3016 9080866 49.47 µM 0.0591061648270711 0.405381418662163 no 2014 0.476433774203376 2310 17066299
SGTC_2780 5215298 71.43 µM 0.0575030032630745 0.404826797213107 no 2015 0.477072256905616 2312 2834131
SGTC_2786 7743617 45.45 µM 0.0574560044181439 0.404810540615265 no 2016 0.477090975783843 2225 583674
SGTC_202 3594-0513 34.79 µM 0.0569558693732907 0.404637557305182 no 2017 0.477290174589306 2311 708429
SGTC_2765 myclobutanil 7.74 µM 0.0557282196549431 0.404213025249678 no 2018 0.477779159197835 2234 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0554213738325156 0.404106932866209 no 2019 0.477901384074359 2272 4330530
SGTC_1648 st011736 69.8 µM 0.0541168115472699 0.403655957405935 no 2020 0.478421049098278 2285 2855514
SGTC_2469 5655019 90.81 µM 0.0539306118458542 0.403591600271682 no 2021 0.478495223711066 2298 2788239
SGTC_307 1501-1223 22.3 µM 0.0527123369687046 0.403170586320333 no 2022 0.478980554606643 2263 2830329
SGTC_2635 hydroquinidine 100 µM 0.0525790561764903 0.403124533669819 no 2023 0.479033652316782 2290 442912 An experimental heart treatment.
SGTC_188 3229-0966 278.469 µM 0.0508917806626603 0.402541643991037 no 2024 0.47970587755265 2317 5722370
SGTC_852 0418-0143 439 µM 0.0490883957303685 0.401918882396368 no 2025 0.480424425562636 2320 5369229
SGTC_3147 9097027 49.47 µM 0.0471604141533583 0.40125336929591 no 2026 0.481192688662732 2271 25236841
SGTC_1383 3049-0032 20.7 µM 0.046473623369898 0.401016367507379 no 2027 0.481466378433087 2314 712864
SGTC_1692 fluoroquinolonic acid 71 µM 0.0461540452652903 0.400906098034036 no 2028 0.481593734989018 2279 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0460041497299784 0.400854379745273 no 2029 0.481653471203515 2324 1273210
SGTC_311 1315-0136 58 µM 0.044877897442138 0.400465845816623 no 2030 0.482102317188497 2313 6759207
SGTC_661 1304-0007 33.6 µM 0.0441059558649057 0.400199598664061 no 2031 0.482409972656427 2294 3117130
SGTC_1851 st056236 18.9 µM 0.0420697624720047 0.399497526497226 no 2032 0.483221542436623 2328 5393171
SGTC_2403 6032726 181.2 µM 0.0420262746699674 0.39948253559459 no 2033 0.483238876229377 2287 2881040
SGTC_1704 st028805 70.8 µM 0.0381373671754336 0.398142572093205 no 2034 0.484789079136096 2266 2876101
SGTC_131 0141-0277 33.849 µM 0.0373265849750737 0.397863359350929 no 2035 0.485112304257127 2325 1547771
SGTC_3284 9108171 64.8615 µM 0.0334245674260608 0.396520337881434 no 2036 0.486668009316285 2302 8687505
SGTC_2393 9031399 185.94 µM 0.0327727325822481 0.396296104335937 no 2037 0.486927911387683 2325 1526623 YDL150W RPC53
SGTC_1403 3909-7815 62.9 µM 0.032612277129848 0.396240912337808 no 2038 0.48699188965258 2321 6615483
SGTC_3271 9137798 49.47 µM 0.0325155068379833 0.396207627183582 no 2039 0.487030474949991 2342 6498326
SGTC_2969 9091408 28.7 µM 0.0317142094263662 0.395932041648517 no 2040 0.487349981551806 2214 4286311
SGTC_986 1493-0483 84 µM 0.031321657067894 0.39579705238228 no 2041 0.487506509518672 2348 40079
SGTC_3206 9114350 49.47 µM 0.0309841694585779 0.395681008542089 no 2042 0.487641082276954 2361 17087243
SGTC_3306 9127676 59.7925 µM 0.0303852575698245 0.395475097721822 no 2043 0.487879901091453 2300 41905287
SGTC_3340 9146634 11.102 µM 0.030038934103921 0.395356042183029 no 2044 0.488018001122789 2303 4907387
SGTC_1930 st074634 34.3 µM 0.0296910681265511 0.395236466206974 no 2045 0.488156717692657 2356 684253 YOR116C RPO31
SGTC_484 loperamide 105 µM 0.0296686580601019 0.395228763274996 no 2046 0.488165654078798 2351 3955 An opioid-receptor agonist.
SGTC_2906 7926292 26.41 µM 0.0288286796329862 0.39494007004605 no 2047 0.488500613671118 2305 2966319
SGTC_1472 k841-0093 193 µM 0.0284030839841035 0.394793818551193 no 2048 0.488670332265682 2341 X1472
SGTC_1132 3456-3614 2.5 µM 0.0273428155625744 0.394429532903731 no 2049 0.489093153870569 2360 3125502
SGTC_2481 5478948 45.16 µM 0.0273305804909592 0.394425329731869 no 2050 0.489098033134475 2330 77792
SGTC_3093 9117344 49.47 µM 0.0264241870909033 0.394113986349299 no 2051 0.48945950118735 2325 24824913
SGTC_233 rapamycin 362 pM 0.0260347325791815 0.393980230673825 no 2052 0.489614817620543 2359 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1141 3253-0389 52.6 µM 0.0242599911562301 0.393370865570941 no 2053 0.490322613081374 2343 5402031
SGTC_1142 3253-1408 9.78 µM 0.0242140470831461 0.393355093936688 no 2054 0.490340936731909 2362 256655
SGTC_1564 D-Arginine 115 µM 0.0239219724392465 0.393254834946215 no 2055 0.490457423912382 2328 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0230039548354159 0.392939757791288 no 2056 0.490823559141304 2353 688803
SGTC_2759 disulfiram 3.38 µM 0.0212424839652237 0.392335391600809 no 2057 0.491526112307576 2359 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1983 st071813 46.9 µM 0.0211291120940403 0.392296502231688 no 2058 0.491571330991303 2265 11838595
SGTC_2612 dictamnine 15.46 µM 0.0210728283866081 0.392277195920912 no 2059 0.491593779943628 2322 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2464 5717415 7.67 µM 0.0195323730451533 0.391748895486211 no 2060 0.492208206004757 2375 5285744
SGTC_2024 5144227 134 µM 0.0185554119025127 0.391413949200996 no 2061 0.492597886426296 2368 3475211
SGTC_3073 9114972 49.47 µM 0.018425964008849 0.391369574666608 no 2062 0.492649519836522 2374 41905075
SGTC_1850 st056238 17 µM 0.016817919045184 0.39081845741748 no 2063 0.493290937293899 2371 5393177
SGTC_1822 st052468 42 µM 0.0123864555789613 0.389300821610159 no 2064 0.495058645519522 2377 2873678
SGTC_879 0831-1030 162 µM 0.0119369631677141 0.389146978555914 no 2065 0.495237953784599 2385 1549252
SGTC_642 0335-0876 158 µM 0.0113759363554445 0.388954986172941 no 2066 0.495461755892688 2378 6812350
SGTC_365 0121-0052 13.6 µM 0.0103437426244023 0.388601823769278 no 2067 0.495873517313802 2375 3101739
SGTC_2231 micatex 6.853 µM 0.00955556011698022 0.388332211141429 no 2068 0.496187941068883 2379 20737 An antifungal of unknown mechanism.
SGTC_1034 k072-0165 12.7 µM 0.00929121875129655 0.388241800254255 no 2069 0.496293393333608 2391 5835461
SGTC_2284 7945075 39.21 µM 0.00924595553630414 0.38822631979048 no 2070 0.496311449968204 2390 1245402
SGTC_2382 9035899 200 µM 0.00847419392158521 0.387962397089714 no 2071 0.496619326214544 2387 6462679
SGTC_465 cgp-37157 41 µM 0.00734789845116877 0.387577325778952 no 2072 0.497068639013907 2389 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_865 0488-0499 301 µM 0.0072682610235574 0.387550102567372 no 2073 0.49710040890248 2394 9634651
SGTC_804 1595-0054 20.9 µM 0.00423606810163226 0.386513991939403 no 2074 0.49831005838573 2390 761523 Stimulates phospholipase C.
SGTC_2452 5863136 48.41 µM 0.00364638060334207 0.386312587398568 no 2075 0.498545307830512 2398 2184096
SGTC_48 0382-0018 55 µM 0.00344372666952195 0.386243379124194 no 2076 0.498626154544846 2399 762596
SGTC_1165 k072-0275 30.3 µM 0.00147904146935741 0.385572608105611 no 2077 0.499409948038536 2400 6153523 YGL055W OLE1
SGTC_2536 dehydroabietamide 32.04 µM 0.00104138397938168 0.385423232233659 no 2078 0.499584547975584 2403 3983547
SGTC_1925 st057770 10.1 µM 0 0.385067868229383 no 2079 0.5 2405 5989122
SGTC_1764 st044502 93.5 µM -0.00142535962659412 0.384581632078114 no 2080 0.499431363972719 2409 8407
SGTC_526 4469-0568 170 µM -0.00220216176574328 0.384316716175709 no 2081 0.49912146527344 2409 2901964
SGTC_2123 5259487 200 µM -0.00220680704046668 0.384315132141703 no 2082 0.499119612081452 2412 2173474
SGTC_2888 9058547 12.99 µM -0.00489486634985811 0.383398831449682 no 2083 0.498047238654065 2418 16476514
SGTC_2897 9048598 12.99 µM -0.00535845602871309 0.383240869615493 no 2084 0.497862295562482 2418 6467404
SGTC_2988 9073640 71.4286 µM -0.00616345198892541 0.382966624395218 no 2085 0.497541153976235 2426 9102229
SGTC_2997 9067075 71.4286 µM -0.00667703070408733 0.382791689550196 no 2086 0.497336269937346 2424 27209819
SGTC_1491 4138-0063 26.5 µM -0.00682395539844612 0.382741648553755 no 2087 0.497277656800275 2420 23883227
SGTC_3282 9108498 15.4605 µM -0.0100166420721296 0.38165473799662 no 2088 0.496004004791668 2434 16459645
SGTC_1657 st012939 43.4 µM -0.0110943142594566 0.381288067934918 no 2089 0.495574099762805 2428 24207257
SGTC_1166 k206-0078 225 µM -0.0114369044425162 0.381171526438188 no 2090 0.495437434727226 2423 5404595
SGTC_3143 9086658 49.47 µM -0.0127399459020819 0.380728359482001 no 2091 0.494917634413264 2457 25236626
SGTC_225 nsc-122657 1.016 µM -0.0127903809882042 0.380711209551459 no 2092 0.494897515364256 2448 275685
SGTC_2150 5556613 200 µM -0.0138880302801922 0.380338023353144 no 2093 0.494459655631498 2442 743190
SGTC_53 0973-0023 39.979 µM -0.0139452447888123 0.380318574229599 no 2094 0.494436832555171 2434 674768
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0149097273187179 0.379990759963098 no 2095 0.494052099753797 2435 803109
SGTC_780 0109-0199 192 µM -0.0156573428890667 0.379736715070931 no 2096 0.493753879132424 2434 610414
SGTC_1610 st001799 48.1 µM -0.0172264676676286 0.379203684613048 no 2097 0.49312797358743 2435 621897
SGTC_1893 st059353 36.1 µM -0.0200155837581067 0.378256791337457 no 2098 0.49201547050735 2468 3112488
SGTC_175 3793-3120 23.7 µM -0.0203068187675505 0.378157960302845 no 2099 0.491899308159849 2449 5322297
SGTC_2184 6075246 200 µM -0.0205482186283724 0.378076046942428 no 2100 0.491803023640185 2456 2267320
SGTC_517 1365-0151 113 µM -0.0216675080486034 0.377696314097258 no 2101 0.491356591252992 2517 768657
SGTC_16 erodoxin 22.806 µM -0.0230830882604852 0.377216230189756 no 2102 0.490791997852955 2462 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_850 0388-0143 75.9 µM -0.0249253535113773 0.376591723292076 no 2103 0.490057252168224 2462 67273
SGTC_204 PMA1.184 62.41 µM -0.0250752558840226 0.376540922279982 no 2104 0.489997468459683 2439 2252213 YGL008C PMA1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0255392314872546 0.376383697294291 no 2105 0.48981242824074 2483 616764
SGTC_305 1682-2595 20.8 µM -0.0263213669490601 0.376118705577896 no 2106 0.489500506226729 2486 226033
SGTC_159 3970-0959 50 µM -0.0266119912089526 0.376020255383622 no 2107 0.489384604522973 2484 6615653
SGTC_3283 9109332 35.8195 µM -0.0280373102444956 0.375537539475136 no 2108 0.488816196781338 2446 17027281
SGTC_1964 st076914 61 µM -0.0281844933280084 0.375487703741562 no 2109 0.48875750242181 2461 24208661
SGTC_2419 paclitaxel 166.5 µM -0.0306648996618765 0.374648159034936 no 2110 0.487768392001014 2444 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1735 st034310 56.75 µM -0.0309435529524261 0.374553880109161 no 2111 0.487657278152694 2627 871153
SGTC_2624 nerol 100 µM -0.0316265086160869 0.374322842153458 no 2112 0.487384951570975 2457 637566 A natural product oil.
SGTC_1736 st036774 51 µM -0.0338499518137729 0.373570983655751 no 2113 0.486498401479714 2455 1272247
SGTC_880 0833-0487 87.2 µM -0.0352204484127182 0.373107788904062 no 2114 0.485951978435097 2463 76075
SGTC_3221 9128209 49.47 µM -0.0370668081275974 0.372484053895982 no 2115 0.485215868554494 2499 16460723
SGTC_2748 diazoxide 86.69 µM -0.0371459721446414 0.372457318265791 no 2116 0.485184308415826 2508 3019 A potassium channel activatior.
SGTC_751 0833-0568 350 µM -0.0380595372747434 0.372148829416742 no 2117 0.484820106248177 2512 6954252
SGTC_2330 7979373 200 µM -0.0393902469138434 0.37169962777871 no 2118 0.48428962785575 2489 1863007
SGTC_2143 5623677 140.463 µM -0.0431238122160618 0.370440239092 no 2119 0.482801418774768 2467 5375313
SGTC_2746 daunorubicin 9.88 µM -0.0434819503809531 0.370319506321104 no 2120 0.482658676213197 2464 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2080 5212524 12.4 µM -0.0449845278150568 0.369813108376554 no 2121 0.482059820742249 2490 260183
SGTC_1818 st052136 56.3 µM -0.0450352791785449 0.369796008110926 no 2122 0.482039594376159 2508 674169
SGTC_1668 st014914 51.6 µM -0.046365359731151 0.369347940007052 no 2123 0.481509522867794 2494 2839556
SGTC_1961 st076550 68.7 µM -0.0475038749018303 0.368964545989344 no 2124 0.481055821049522 2542 1579337
SGTC_1495 4469-0029 237 µM -0.047615377626844 0.36892700454307 no 2125 0.48101138817834 2491 793680
SGTC_1862 st057513 3.81 µM -0.0478864082416574 0.368835757447279 no 2126 0.480903385808036 2499 5393163
SGTC_2722 naftopidil 47.16 µM -0.0487525706363348 0.368544198640139 no 2127 0.480558240171521 2495 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1497 4476-2978 41.3 µM -0.049078745043794 0.368434424718917 no 2128 0.480428270994553 2563 1528379
SGTC_2899 9053889 58.44 µM -0.0491677432727961 0.368404474249823 no 2129 0.480392808650926 2504 6470052
SGTC_1123 mangostin 811.285 nM -0.0493598108300602 0.368339840706163 no 2130 0.480316277705357 2555 5281650 An antioxidant.
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0507477326848662 0.367872895529593 no 2131 0.479763270220956 2492 15053
SGTC_1232 0279-0259 161 µM -0.05087999361323 0.367828408529988 no 2132 0.479710573820895 2510 1560000
SGTC_247 mechlorethamine 29.705 µM -0.051176788327493 0.367728585756397 no 2133 0.479592323916741 2489 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_566 0958-0068 16.5 µM -0.0513989932527386 0.36765385606879 no 2134 0.479503793491262 2508 6815365
SGTC_3205 9113483 49.47 µM -0.0523886798384457 0.367321075691495 no 2135 0.479109496955965 2542 17018033
SGTC_537 1334-0398 209 µM -0.0541366478087958 0.366733568036202 no 2136 0.47841314715852 2492 5846986
SGTC_2506 ethyl hematommate 54.16 µM -0.0559194889361593 0.366134660645388 no 2137 0.477702972597518 2554 3940691 An allergen.
SGTC_1642 st009582 77.7 µM -0.0561453166502984 0.366058821879747 no 2138 0.477613021691633 2523 6739311
SGTC_3319 9138450 16.7555 µM -0.0567107786383506 0.365868948133189 no 2139 0.477387793861957 2537 2029690
SGTC_269 exalamide 29 µM -0.0567808019003158 0.36584543764558 no 2140 0.477359903562885 2533 3316 A derivative of salicylamide.
SGTC_2873 9040596 71.43 µM -0.057358318691112 0.365651554140066 no 2141 0.477129882587398 2615 6463863
SGTC_2874 9043904 71.43 µM -0.0599655282674575 0.364776691501092 no 2142 0.476091544859925 2581 4463428
SGTC_598 3937-0236 20.2 µM -0.061588318022213 0.364232510990479 no 2143 0.475445340074868 2566 1379313
SGTC_2041 5107442 45.335 µM -0.0615985762733536 0.36422907189432 no 2144 0.475441255380279 2524 793005
SGTC_3275 9138069 49.47 µM -0.0626595195474021 0.363873447934352 no 2145 0.475018816369431 2605 17617007
SGTC_66 0109-0187 42.4 µM -0.0637816132144298 0.363497454154617 no 2146 0.474572059487063 2504 759417
SGTC_3151 9099821 49.47 µM -0.0642089743628402 0.363354287524799 no 2147 0.4744019158172 2600 17174189
SGTC_1785 bathophenanthroline 24 µM -0.0668417832944244 0.3624727142132 no 2148 0.473353829755313 2538 72812 An iron chelator.
SGTC_953 1188-0045 9.7 µM -0.0669610886378252 0.362432783074765 no 2149 0.473306340205502 2594 6144426
SGTC_2337 9009472 200 µM -0.0670170373150645 0.362414057736762 no 2150 0.473284069938021 2540 5742383
SGTC_1794 st048918 76.9 µM -0.0672392072399633 0.362339703429236 no 2151 0.473195636435211 2505 672303
SGTC_3229 9132204 49.47 µM -0.0692117090826114 0.361679788047917 no 2152 0.472410551479508 2531 17682924
SGTC_2237 6667747 47.222 µM -0.0697891263427152 0.361486686455126 no 2153 0.472180750998511 2594 729940 YDL015C TSC13
SGTC_1049 3226-0134 66 µM -0.0698390385641871 0.361469996317731 no 2154 0.472160887369816 2504 5702385
SGTC_1079 idarubicin 2.36 µM -0.071945564403559 0.360765836273832 no 2155 0.471322614413088 2527 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1380 2291-0730 164 µM -0.0720086870738281 0.360744743178167 no 2156 0.471297497257716 2592 2999191
SGTC_970 1315-0089 19.5 µM -0.0737405471638314 0.360166189600974 no 2157 0.470608417313246 2533 6811083 YLR033W RSC58
SGTC_103 0844-0104 51.839 µM -0.076338790840785 0.359298808433284 no 2158 0.469574782619891 2651 5375804
SGTC_1662 st014054 52 µM -0.0766355521838204 0.359199785536356 no 2159 0.469456737777042 2525 2838777
SGTC_2094 5332512 191.667 µM -0.0768649384623336 0.359123250733993 no 2160 0.469365495025627 2626 755774
SGTC_1350 1495-0454 146 µM -0.078091350538455 0.358714153951353 no 2161 0.468877693727299 2625 1069057
SGTC_501 nsc-95397 161 µM -0.0780995257648445 0.358711427467549 no 2162 0.468874442214296 2678 262093
SGTC_1356 1502-0781 85.8 µM -0.0784109043782878 0.358607586316214 no 2163 0.468750599899468 2529 567702
SGTC_2680 butyl paraben 22.24 µM -0.0792499584202653 0.358327823585843 no 2164 0.468416904220792 2540 7184 An antifungal and steroid mimetic.
SGTC_222 nsc-310342 10.666 µM -0.0796515391693344 0.358193952874422 no 2165 0.468257201533689 2536 432556
SGTC_1205 4161-2785 76 µM -0.0810174623980529 0.357738740112122 no 2166 0.467714032585192 2693 3498106
SGTC_1637 st007924 17.4 µM -0.0815172521850259 0.357572228778904 no 2167 0.467515302639008 2550 683336
SGTC_2876 9059903 25.97 µM -0.0826223405805456 0.357204150774383 no 2168 0.467075918396813 2551 6916095
SGTC_1282 0886-0010 32.4 µM -0.0834135165119692 0.356940710933873 no 2169 0.466761370672212 2577 2836211 YNL267W PIK1
SGTC_3323 9138564 53.9225 µM -0.0834150603386055 0.356940196948666 no 2170 0.466760756913461 2575 43912313 YNL103W MET4
SGTC_158 k038-0087 26.446 µM -0.0834159284207708 0.356939907938744 no 2171 0.466760411801543 2553 X158
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0851355784471411 0.3563675475621 no 2172 0.4660768027315 2529 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0887853841163675 0.355153835995767 no 2173 0.464626236799576 2689 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0889551148553009 0.355097429123603 no 2174 0.464558790899395 2542 5355888
SGTC_2038 4100038 30.985 µM -0.0912787338694019 0.354325537076574 no 2175 0.463635557675605 2641 3596803
SGTC_1385 3091-4834 14.1 µM -0.094411408949068 0.353285828581241 no 2176 0.462391176628526 2657 4072814
SGTC_2723 salbutamol 83.58 µM -0.096407907842065 0.352623777665489 no 2177 0.461598305915714 2631 9884233 β2-adrenoceptor agonist
SGTC_1074 carmofur 3.8 µM -0.0964359036519384 0.352614497255594 no 2178 0.461587189001779 2572 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2922 7999257 32.47 µM -0.0967930586326822 0.35249611064422 no 2179 0.461445368229996 2574 2988377
SGTC_987 1497-1013 404 µM -0.0970628510089748 0.352406691697088 no 2180 0.461338241059712 2567 1676435
SGTC_1884 5633444 25 µM -0.097402837788143 0.352294019403886 no 2181 0.461203245608781 2687 5724239
SGTC_1952 st077036 64.1 µM -0.0981758284762968 0.352037897007924 no 2182 0.46089633790371 2574 2937007
SGTC_2207 7258803 200 µM -0.0985474364853336 0.351914792452451 no 2183 0.460748803187049 2588 3666799
SGTC_2336 9001819 198.65 µM -0.0995001501048457 0.35159925289385 no 2184 0.460370584362957 2705 2989602
SGTC_774 k060-0086 136 µM -0.101560931301375 0.350917070343263 no 2185 0.459552595674398 2576 5911235
SGTC_919 tnp00227 403.569 nM -0.10167767657089 0.350878438389246 no 2186 0.459506260906657 2639 1269246 A methoxyflavone. YNL221C POP1
SGTC_1758 st042942 75.2445 µM -0.102011908680286 0.350767846805995 no 2187 0.459373611319112 2568 669317
SGTC_1650 st011916 45.8 µM -0.102227649001031 0.350696468805524 no 2188 0.45928799099331 2604 242528
SGTC_1338 1486-1223 76 µM -0.102833812017454 0.350495947097973 no 2189 0.459047434699948 2666 3444526
SGTC_195 4234-0266 16.654 µM -0.103025832623998 0.350432434421838 no 2190 0.458971234286909 2615 2303354
SGTC_446 go6976 132 µM -0.105443079123734 0.349633264885651 no 2191 0.458012117184396 2640 3501 A protein kinase C inhibitor.
SGTC_2918 7977171 22.06 µM -0.105855124147963 0.349497104387282 no 2192 0.457848649843756 2579 2236483
SGTC_2087 5276107 200 µM -0.10682725880805 0.349175938724616 no 2193 0.457463010905955 2598 144405
SGTC_1404 3909-7820 48.3 µM -0.109983930266203 0.348133809829179 no 2194 0.45621105969073 2616 23741373
SGTC_594 1487-1584 10.8 µM -0.111761880792981 0.347547349339811 no 2195 0.455506106413919 2627 5013332
SGTC_1104 tacrolimus 29.8 µM -0.112662985782625 0.347250257246363 no 2196 0.455148873712263 2594 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3263 9137018 49.47 µM -0.113704494064453 0.346906991445959 no 2197 0.454736024940771 2624 43844957
SGTC_909 3448-9333 149 µM -0.114512920631845 0.346640632519058 no 2198 0.454415602295594 2616 3344074
SGTC_7 0192-1582 4.227 µM -0.115059319494933 0.346460648924749 no 2199 0.454199052016742 2620 252616
SGTC_2160 5660466 132.927 µM -0.115172289904476 0.346423440833912 no 2200 0.454154280973959 2582 2859134
SGTC_410 α-linolenic acid 100 µM -0.115776240506665 0.346224547971457 no 2201 0.453914940597278 2727 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_499 genistein 192 µM -0.116415279936 0.346014145835519 no 2202 0.453661713046558 2640 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_529 4076-0302 30.3 µM -0.116824603743723 0.345879401963254 no 2203 0.453499523141322 2625 5816522
SGTC_3033 9090887 49.47 µM -0.119327926850492 0.345055766996783 no 2204 0.452507779569208 2632 19325384
SGTC_2369 9071472 200 µM -0.120047107759689 0.344819279971653 no 2205 0.452222915580726 2749 17296037
SGTC_2149 5554786 194.827 µM -0.120107807403319 0.344799322984613 no 2206 0.452198873876563 2630 745063 YPR165W RHO1
SGTC_407 eburnamonine 100 µM -0.12091782049107 0.344533046121404 no 2207 0.451878063514571 2609 3195
SGTC_2106 5357045 167.29 µM -0.122510703275992 0.344009640037399 no 2208 0.451247284928202 2736 668842
SGTC_2270 7924575 90.91 µM -0.124300173573765 0.34342199351243 no 2209 0.450538804937969 2848 1262135
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.12701640966746 0.34253072839394 no 2210 0.44946370535349 2659 115019
SGTC_509 pifithrin 175 µM -0.128266202620695 0.342120933976161 no 2211 0.448969155268311 2642 4817 A p53 inhibitor.
SGTC_472 calcifediol 10 µM -0.12890034301895 0.341913076831035 no 2212 0.448718252622257 2709 5283731 A vitamin D metabolite.
SGTC_199 4063-0024 41.6 µM -0.129118165614422 0.341841690470816 no 2213 0.448632074122805 2742 306215
SGTC_2616 abietic acid 100 µM -0.129343217934225 0.34176794067349 no 2214 0.448543037828614 2661 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_936 3005-4620 401 µM -0.129410154678062 0.341746006622305 no 2215 0.448516556488066 2763 777207
SGTC_3136 9095672 49.47 µM -0.13057670358776 0.341363833906191 no 2216 0.448055086378235 2582 17217380
SGTC_482 fipronil 114 µM -0.13082081675826 0.341283880631466 no 2217 0.447958527562449 2627 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1951 sophoraflavanone G 9.2 µM -0.131089433834578 0.341195909936761 no 2218 0.447852279805262 2630 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1716 st033144 30.6155 µM -0.133240191127557 0.340491859654076 no 2219 0.447001713136076 2709 674617
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.133946352089114 0.340260818916494 no 2220 0.44672249842275 2644 2724 A muscle relaxant with antifungal properties.
SGTC_1247 0448-0043 5.84 µM -0.135928047328951 0.339612771127068 no 2221 0.445939081344373 2747 3089013 YGL099W LSG1
SGTC_2707 st078556 66.6 µM -0.139213713445779 0.338539347730262 no 2222 0.444640636131507 2732 17250899
SGTC_897 1000-0139 31.4 µM -0.140166328955025 0.338228373981454 no 2223 0.444264287416203 2758 6151020
SGTC_2947 9072639 7.68 µM -0.14033445490812 0.33817350205043 no 2224 0.444197871296161 2717 16488146
SGTC_185 k048-0037 25.491 µM -0.141952092962469 0.337645722920413 no 2225 0.443558923329825 2644 6827589
SGTC_1616 st002734 56.1 µM -0.142242425454558 0.33755103125954 no 2226 0.443444260897746 2676 4026101
SGTC_2015 5119600 184 µM -0.143597087341832 0.33710934562891 no 2227 0.442909320392268 2801 2828786
SGTC_634 1611-4317 11.2 µM -0.145748471703969 0.336408351205173 no 2228 0.44205997750671 2649 2843522
SGTC_2320 7373003 200 µM -0.146076685948008 0.336301457707915 no 2229 0.441930425447722 2710 5415828
SGTC_1242 0402-0103 60.1 µM -0.146643614750693 0.336116850328545 no 2230 0.441706663101501 2673 432868
SGTC_308 4092-1169 104 µM -0.149980234399979 0.33503115854404 no 2231 0.440390104761987 2686 2268590 YDL196W YDL196W
SGTC_1359 1582-0056 520 nM -0.150147862698905 0.334976650772591 no 2232 0.440323979498284 2774 3661189
SGTC_2298 7976326 193.81 µM -0.150172346954162 0.334968689506884 no 2233 0.44031432119773 2714 2235818
SGTC_1990 st072050 59.8 µM -0.150775612095663 0.33477255609981 no 2234 0.440076362517342 2630 17233948
SGTC_1211 1056-0033 32.3 µM -0.151231230829861 0.334624455322592 no 2235 0.439896657485946 2689 6741922
SGTC_3024 9090631 49.47 µM -0.15199334840575 0.334376783328752 no 2236 0.439596090951233 2678 25236383
SGTC_2274 7947094 46.08 µM -0.152353692418481 0.334259704282095 no 2237 0.439453989359373 2656 2971028
SGTC_1632 st005650 90 µM -0.153304456722407 0.333950869727637 no 2238 0.439079093132785 2795 2759605
SGTC_271 rotenone 740 µM -0.153794141767489 0.333791850324595 no 2239 0.438886026537497 2810 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3057 9095946 49.47 µM -0.154239910498003 0.333647118173719 no 2240 0.43871028733139 2658 24540043
SGTC_145 3737-0113 38.366 µM -0.154294371371128 0.33362943751872 no 2241 0.438688817584758 2797 6849351
SGTC_1672 st016598 6.51 µM -0.155507303915722 0.333235756283724 no 2242 0.438210698147883 2742 4665860 YNL267W PIK1
SGTC_2848 9016370 25.97 µM -0.15555850280359 0.333219142709488 no 2243 0.438190518308913 2705 7894410
SGTC_113 0099-0221 2.5 µM -0.156366952044078 0.332956851670458 no 2244 0.437871892580512 2692 89219
SGTC_1017 4239-0030 168 µM -0.156723026080264 0.332841353904825 no 2245 0.437731569571702 2716 1149593
SGTC_2543 pimpinellin 60.67 µM -0.157467731453361 0.332599849222366 no 2246 0.437438118583934 2684 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3160 9100216 49.47 µM -0.158054328617894 0.332409667235888 no 2247 0.437206994320156 2643 17191039
SGTC_1688 st021091 57.6 µM -0.158308676014815 0.332327218098733 no 2248 0.437106785941217 2676 3656366
SGTC_1647 st011722 22.4 µM -0.158583341057691 0.332238191914371 no 2249 0.43699857730025 2828 2854783
SGTC_1700 st030840 7.9285 µM -0.159029100725673 0.332093729598718 no 2250 0.436822973258703 2801 5499307
SGTC_1111 tnp00062 510.699 nM -0.160721002364201 0.331545643361469 no 2251 0.436156573492686 2817 676306
SGTC_2480 5767542 37.17 µM -0.160755011159286 0.331534630010981 no 2252 0.436143180089536 2728 2867358
SGTC_550 4123-0385 25.7 µM -0.161259681177231 0.331371215650462 no 2253 0.435944438674148 2703 5731123
SGTC_659 k018-0002 107 µM -0.164003588076377 0.330483289004583 no 2254 0.434864159591625 2780 6797879 YHR007C ERG11
SGTC_3140 9094243 49.47 µM -0.16571925042445 0.329928585753159 no 2255 0.434188947941453 2661 19291112
SGTC_2904 7225135 42.03 µM -0.165729650596749 0.329925224336456 no 2256 0.434184855459816 2796 4446116
SGTC_1441 4106-0040 13 µM -0.167693637610512 0.329290694861222 no 2257 0.433412150880613 2688 2904180
SGTC_117 lucigenin 22.078 µM -0.168551972900592 0.329013536094196 no 2258 0.433074530002934 2741 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_152 4469-0003 551.229 µM -0.169674462054538 0.328651223157263 no 2259 0.432633079574972 2710 697280
SGTC_3048 9093155 49.47 µM -0.170662501774332 0.328332440537578 no 2260 0.432244574718485 2720 25236002
SGTC_2487 5918373 44.05 µM -0.171396843601668 0.328095592315444 no 2261 0.431955868248971 2694 2876279
SGTC_1280 0880-0253 10.1 µM -0.171400611200743 0.328094377324926 no 2262 0.431954387111057 2748 6836607
SGTC_1590 st077108 57.8 µM -0.171722836282299 0.327990471614499 no 2263 0.431827715871842 2684 5489485
SGTC_1209 2323-2347 50.3 µM -0.172382449795326 0.327777812094546 no 2264 0.43156843433909 2697 5412760
SGTC_1401 3807-4679 7.6 µM -0.17288498150967 0.327615833249004 no 2265 0.431370918454825 2699 3291456
SGTC_2154 5570129 200 µM -0.173541097433911 0.327404399103891 no 2266 0.431113063417034 2692 673366
SGTC_2226 7298446 200 µM -0.174623113910754 0.327055838929115 no 2267 0.430687892682248 2759 3283010
SGTC_2545 solidagenone 89.61 µM -0.175929768413821 0.326635115015586 no 2268 0.430174559137994 2673 6708572 An anti ulcer agent
SGTC_832 4083-0019 164 µM -0.176657720833913 0.326400820382257 no 2269 0.429888626173848 2841 1990758
SGTC_497 capsazepine 133 µM -0.177169426915356 0.326236166546992 no 2270 0.429687654765596 2732 2733484 A calcium channel blocker.
SGTC_213 1246-0773 967 nM -0.178733308886478 0.325733159618493 no 2271 0.429073556795601 2745 6251622
SGTC_975 1335-0046 28.5 µM -0.179398542053226 0.325519290127632 no 2272 0.428812388045109 2767 16486740
SGTC_76 0433-0009 400.328 µM -0.180164623630512 0.325273069477283 no 2273 0.428511665098958 2866 2841569
SGTC_3195 9113082 49.47 µM -0.180511983477503 0.32516145222251 no 2274 0.428375323734219 2721 17018038
SGTC_38 0929-0051 58.268 µM -0.18111213012852 0.324968643867725 no 2275 0.428139781792034 2841 1379719
SGTC_2387 9077560 195.08 µM -0.181151766065819 0.324955911729726 no 2276 0.428124226618449 2721 5303272
SGTC_1618 st003135 44.5 µM -0.181390183604152 0.324879329864353 no 2277 0.428030661712133 2654 1270615
SGTC_2400 5203494 178.7 µM -0.184227789706848 0.32396843408541 no 2278 0.42691737977296 2691 6777674
SGTC_1375 2910-0797 186 µM -0.184970793087662 0.323730097403172 no 2279 0.426625971993481 2804 742508
SGTC_2266 7929956 200 µM -0.185416082640974 0.32358729441127 no 2280 0.426451347501868 2711 2967153
SGTC_2104 5389443 200 µM -0.185672626800891 0.323505033279177 no 2281 0.426350747837276 2902 2244536
SGTC_3269 9137823 49.47 µM -0.187267341835299 0.322993879942481 no 2282 0.4257255137155 2738 17682936
SGTC_2325 6158266 200 µM -0.188212454929224 0.322691100861292 no 2283 0.425355054672799 2817 3623240
SGTC_2551 apiole 73.87 µM -0.189586416954939 0.322251144176354 no 2284 0.42481661593417 2728 10659 A possible DNA adduct former.
SGTC_556 4058-0063 51.5 µM -0.191509368165497 0.321635813567815 no 2285 0.424063270819529 2747 6615692
SGTC_1314 1222-0010 41.1 µM -0.19168571705015 0.321579407641658 no 2286 0.423994197331038 2790 3526027
SGTC_848 0368-0089 85.6 µM -0.192072055856924 0.321455849940322 no 2287 0.423842881775281 2854 762535
SGTC_1876 myriocin 605 nM -0.192449060922685 0.321335296369456 no 2288 0.423695232747385 2863 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_912 3474-0017 2.18 µM -0.192822703983145 0.321215836423855 no 2289 0.423548910973477 2903 3360550
SGTC_94 0334-0113 514.748 µM -0.192965210691469 0.321170279513842 no 2290 0.423493106920477 2761 6795178
SGTC_200 k038-0079 37.545 µM -0.1932493027285 0.321079468273234 no 2291 0.423381864196442 2777 3436683
SGTC_1438 4092-1045 4 µM -0.19375817807238 0.32091683083292 no 2292 0.42318261770868 2744 1351342
SGTC_2401 5128683 200 µM -0.193983724865517 0.320844756674329 no 2293 0.423094312761091 2790 708373
SGTC_3353 9151644 39.2805 µM -0.197603031555658 0.319689121284523 no 2294 0.421677831368705 2870 4909158
SGTC_2854 9024559 71.43 µM -0.198586469973572 0.319375413513007 no 2295 0.421293119106654 2844 3163529
SGTC_1924 st058459 75.1 µM -0.198795352381959 0.319308798588508 no 2296 0.421211415848523 2741 688683
SGTC_2708 st078559 56 µM -0.201234602532317 0.318531326772481 no 2297 0.420257567982814 2799 17250902
SGTC_1333 1482-0047 286 µM -0.201360942724207 0.318491079582669 no 2298 0.420208176436918 2848 3811116
SGTC_1826 st055655 41.6 µM -0.202775794726628 0.318040507821919 no 2299 0.419655138950471 2823 676168
SGTC_722 3534-0461 190 µM -0.20427578072202 0.317563118363288 no 2300 0.419068997552207 2809 658262
SGTC_381 3461-2219 42.7 µM -0.205000453615124 0.317332590656896 no 2301 0.418785885309189 2890 2883159
SGTC_1151 3909-8316 15.3 µM -0.206014187265924 0.317010227908765 no 2302 0.418389914587157 2861 800431
SGTC_3327 9140648 26.9345 µM -0.206047673136193 0.316999581919967 no 2303 0.418376836204851 2891 8029710
SGTC_3161 9100388 49.47 µM -0.206106567738067 0.316980858232636 no 2304 0.418353834300409 2782 25236368
SGTC_1816 st051957 91.6 µM -0.206383394065606 0.316892856282841 no 2305 0.418245720616657 2807 674121
SGTC_766 1391-0721 126 µM -0.208536392597393 0.316208780789565 no 2306 0.417405084998714 2961 1020919 YIL115C NUP159
SGTC_1762 st045503 25.4615 µM -0.208908319252102 0.316090671578439 no 2307 0.417259904814543 2847 4645554
SGTC_2900 5328528 85.29 µM -0.209076184644337 0.316037370307674 no 2308 0.417194382877285 2770 795359
SGTC_884 0851-0618 334 µM -0.212031256182834 0.315099691479942 no 2309 0.41604132487639 2925 9642473
SGTC_2192 5915882 198.485 µM -0.212115978183291 0.315072825719437 no 2310 0.416008277268983 2774 2876149
SGTC_488 nitrendipine 139 µM -0.212287607808343 0.315018404124529 no 2311 0.415941331325673 2754 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_935 2996-0153 430 µM -0.213027765708543 0.314783755376339 no 2312 0.415652652903879 2945 23738523
SGTC_3225 9130819 49.47 µM -0.213267061977638 0.314707908403256 no 2313 0.415559331643002 2899 4547121
SGTC_1769 st044406 64.4 µM -0.214148155863237 0.314428705654546 no 2314 0.415215761891493 2787 670903
SGTC_1489 4065-0444 182 µM -0.21461628106648 0.314280408381846 no 2315 0.41503324962604 2859 2877968
SGTC_2798 7813637 45.45 µM -0.216308211881461 0.313744672082913 no 2316 0.414373754215544 2925 956368
SGTC_693 4161-2696 114 µM -0.216436575846223 0.313704042669843 no 2317 0.414323729226407 2895 805759
SGTC_2089 5281248 129.67 µM -0.217781683390405 0.313278428848943 no 2318 0.413799608288503 2796 2737878
SGTC_2477 5967686 25.23 µM -0.218464073934787 0.313062604429606 no 2319 0.413533773560367 2779 776118
SGTC_1089 terbinafine 2.25 µM -0.219904099082606 0.312607367838913 no 2320 0.412972921923387 2916 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2996 9066192 71.4286 µM -0.220488204969311 0.312422795280859 no 2321 0.41274547871817 2836 6472854
SGTC_3278 9139605 49.47 µM -0.220582940531114 0.312392864071535 no 2322 0.412708592686002 3002 7958859
SGTC_3190 9110366 49.47 µM -0.220714167743884 0.312351405559193 no 2323 0.412657499617447 2884 17123768
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.222029465425205 0.311935995870958 no 2324 0.412145472826224 2801 16623 A steroid.
SGTC_2534 helenine 20.12 µM -0.222224724756526 0.31187434760138 no 2325 0.412069473853658 2776 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2652 actinonin 100 µM -0.22399732845329 0.311314933407925 no 2326 0.41137969100422 2782 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1199 1638-0010 4.46 µM -0.225002882114635 0.310997785235962 no 2327 0.410988516073233 2794 3111136
SGTC_1866 st057638 64 µM -0.225368109382395 0.310882628534363 no 2328 0.410846459267357 2824 688802
SGTC_667 1498-1044 59 µM -0.226679525732786 0.310469289698247 no 2329 0.410336474411241 2843 6739982
SGTC_2657 nystatin 74.44 µM -0.227078866433486 0.310343470964577 no 2330 0.410181208482725 2853 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_895 0964-0006 13.7 µM -0.227629761419844 0.310169939031462 no 2331 0.409967040501438 2908 6738897
SGTC_1998 st075797 76.8 µM -0.228934723393758 0.309759044666795 no 2332 0.409459825901027 2788 24208315
SGTC_527 4476-4215 268 µM -0.229459012170126 0.309594028335645 no 2333 0.409256087161126 2824 4418754
SGTC_1747 st037496 66.6 µM -0.235915700452508 0.307564984194822 no 2334 0.406749042440109 2843 723305
SGTC_1262 0737-0114 49.6 µM -0.237869917964434 0.306952017276468 no 2335 0.405990993947725 2948 765919
SGTC_463 ikarugamyin 104 µM -0.238319876928388 0.306810957836476 no 2336 0.405816502931714 2825 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2397 5161689 200 µM -0.239243801209897 0.306521402785073 no 2337 0.40545827008966 3037 2259942
SGTC_2648 atorvastatin 78.68 µM -0.239385600782908 0.30647697391465 no 2338 0.405403297191347 2933 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2305 7443522 69.23 µM -0.239649002212647 0.306394452104362 no 2339 0.40530118660432 2833 5415886
SGTC_1061 3448-9325 110 µM -0.23969074759252 0.306381374472491 no 2340 0.405285004120271 2800 723482
SGTC_2774 tamoxifen 10.92 µM -0.240166877980976 0.306232233909754 no 2341 0.405100444919696 2799 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2933 9026794 32.47 µM -0.240843911512379 0.306020218793415 no 2342 0.404838047341541 2886 17586027
SGTC_1313 1220-0047 237 µM -0.244797715785577 0.304783372295073 no 2343 0.403306531329098 2879 3528706
SGTC_2676 harmalol 100 µM -0.246328517575429 0.304305097548767 no 2344 0.402713968045134 2919 5459187 A monoamine oxidase inhibitor
SGTC_2212 7123476 200 µM -0.247389762592204 0.303973724661798 no 2345 0.402303298137564 2869 1085715
SGTC_978 1416-0512 87.4 µM -0.247585831635921 0.30391251987574 no 2346 0.402227437099396 2912 6814003
SGTC_3305 9127027 53.8275 µM -0.250887762224111 0.302882618141683 no 2347 0.40095044310467 2890 41905295
SGTC_1277 0873-0036 22 µM -0.253663096576264 0.302018177047283 no 2348 0.399877923182232 2939 5965735
SGTC_1940 st075990 51.1 µM -0.253838766735648 0.301963497880806 no 2349 0.399810061276636 3095 1084979
SGTC_1230 0170-0365 3.77 µM -0.254153082448391 0.301865674940235 no 2350 0.399688647733123 2959 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3046 9092212 49.47 µM -0.255520705851017 0.301440202092602 no 2351 0.399160476655213 2844 25236637
SGTC_1160 4092-0570 10.5 µM -0.257871806686875 0.300709397263215 no 2352 0.398252922076734 2865 4994975
SGTC_1868 st057644 42.7 µM -0.258296879293872 0.300577355141356 no 2353 0.398088897267853 2843 688665
SGTC_2004 4023728 41.89 µM -0.258347909668194 0.30056150511812 no 2354 0.398069207142336 3012 360084 YDR527W RBA50
SGTC_2351 9026858 72.31 µM -0.259540485317734 0.300191198901071 no 2355 0.397609124550276 2840 1409300
SGTC_2564 betulinic acid 100 µM -0.261075544453 0.299714852170243 no 2356 0.397017125264846 3160 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1358 1509-0022 2.48 µM -0.26154298961505 0.299569866521509 no 2357 0.396836900956382 2930 3258434
SGTC_1993 st073995 70.8 µM -0.26165951710813 0.299533728591866 no 2358 0.396791977004785 2901 3098394
SGTC_2824 7998404 51.95 µM -0.264342427717787 0.298702241659302 no 2359 0.395758035000869 2850 837851
SGTC_1032 k061-1018 98.7 µM -0.264377708089765 0.298691314569038 no 2360 0.395744443493784 3065 4005393
SGTC_1698 5-fluorocytosine 1.055 µM -0.264455851400056 0.298667112551638 no 2361 0.395714339802381 2997 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2349 9023730 187.07 µM -0.264584871972545 0.298627155124283 no 2362 0.395664637670679 3016 4126287
SGTC_1896 st058441 89 µM -0.264847819316203 0.298545728355667 no 2363 0.395563348663266 2908 688759
SGTC_592 k241-0073 46.5 µM -0.264997908175289 0.298499254943923 no 2364 0.395505536631465 2992 4230158
SGTC_3352 9151559 45.5865 µM -0.26591656460875 0.298214874545735 no 2365 0.395151733771186 2964 17159339
SGTC_2788 5282734 71.43 µM -0.267476834113647 0.297732158592289 no 2366 0.394551024153383 3034 743706
SGTC_1929 genistein trimethyl ether 50.5 µM -0.267908636755573 0.297598630557563 no 2367 0.394384822738462 3071 136420
SGTC_2405 ticlatone 3.52 µM -0.269546854581338 0.297092286742869 no 2368 0.393754445582363 2748 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1252 0493-0875 34.8 µM -0.270749690704181 0.296720762618195 no 2369 0.393291777991812 2857 3960963
SGTC_3063 1327-0034 4 µM -0.271397919395534 0.296520630250366 no 2370 0.393042501048753 2961 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1718 roemerine 11.9335 µM -0.27253674934525 0.296169180846367 no 2371 0.392604669188623 3025 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1911 st060208 74.3 µM -0.274400311032988 0.295594487717558 no 2372 0.391888502005316 2994 688783
SGTC_1192 1488-0095 21.4 µM -0.274910611292458 0.295437208597259 no 2373 0.391692457256761 2971 915875
SGTC_1753 st043925 64 µM -0.275088527317359 0.295382382332801 no 2374 0.391624112779929 3002 670181
SGTC_604 1000-0114 314 µM -0.275568204789835 0.295234589161667 no 2375 0.391439866645822 3043 1572745
SGTC_377 3970-0964 33.1 µM -0.278547215633709 0.29431749080384 no 2376 0.390296162836105 2881 16481235
SGTC_2110 5483698 200 µM -0.279626684787912 0.293985497688003 no 2377 0.389881965989991 2957 2848765 YHR062C RPP1
SGTC_572 0960-0087 17.7 µM -0.279805067090438 0.293930652492764 no 2378 0.389813531975145 2929 6796365
SGTC_2462 5162487 171.77 µM -0.282761491807903 0.293022363786895 no 2379 0.388679837595686 2862 2259986
SGTC_1322 1348-1070 12 µM -0.283527348311722 0.292787285751075 no 2380 0.388386310227265 2985 6758089
SGTC_1307 1187-1599 12.2 µM -0.284739034389031 0.292415540239931 no 2381 0.387922041426583 2903 1538471
SGTC_1832 st054113 55 µM -0.284986054580757 0.29233978133586 no 2382 0.387827412972779 3021 1251267
SGTC_2688 kanamycin b 96.69 µM -0.285842906511493 0.292077063209974 no 2383 0.387499221940857 3050 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.287291851381076 0.291633054543716 no 2384 0.386944430728207 2896 3256 An antibiotic and ribosome inhibitor.
SGTC_226 1,3-diallylurea 8.28947 mM -0.287451674989444 0.291584098133433 no 2385 0.38688324946658 3010 74537 YKL182W FAS1
SGTC_1366 1683-0113 21.9 µM -0.287762837262772 0.291488795374617 no 2386 0.386764143085611 2907 708623
SGTC_3141 9094609 49.47 µM -0.287859318743184 0.29145924798479 no 2387 0.386727214167409 2866 25236309 YDL196W YDL196W
SGTC_1829 berberine 14.4 µM -0.288536615054185 0.291251865775383 no 2388 0.386468003459555 3094 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_917 harmaline 728.087 nM -0.288997974105694 0.291110641119203 no 2389 0.386291463936687 3025 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_250 brefeldin a 552.239 µM -0.291064426062786 0.290478481069266 no 2390 0.38550102323468 2895 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_59 0330-0160 1.33 µM -0.291268973234682 0.290415941846601 no 2391 0.385422807482639 2956 4293482
SGTC_2515 chrysin 20.77 µM -0.292279691984247 0.290107012466303 no 2392 0.385036392341294 2998 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2726 cimetidine 79.27 µM -0.293254672956067 0.289809152469823 no 2393 0.384663748515154 2922 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_455 paf C-16 10 µM -0.293366249291013 0.289775074671663 no 2394 0.384621110129125 2908 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3040 9091894 49.47 µM -0.29346433537711 0.289745118636876 no 2395 0.384583628132707 2917 25236966
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.293873147416443 0.289620280824551 no 2396 0.384427418909282 3051 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3333 9141820 12.094 µM -0.294091763216817 0.289553533079786 no 2397 0.384343892365084 2949 1939433
SGTC_2806 7952793 58.44 µM -0.29477857110201 0.289343884000315 no 2398 0.384081518612177 3074 2972490
SGTC_20 0481-0013 4.944 µM -0.296155607080534 0.288923756823685 no 2399 0.383555624638798 2962 182045
SGTC_1447 4239-0816 81.9 µM -0.296664849005886 0.288768462255785 no 2400 0.383361197955122 2936 1341554
SGTC_1425 4048-4433 7.33 µM -0.297362284389507 0.288555841423156 no 2401 0.383094967371673 3002 23734946
SGTC_1200 1643-0193 18.4 µM -0.297379062596234 0.288550727311365 no 2402 0.383088563340687 3024 5403974
SGTC_1792 st045773 43.6 µM -0.297644675233334 0.288469772458753 no 2403 0.382987186587744 2912 2919270
SGTC_1968 st069590 43.6 µM -0.300902622116713 0.287477669789882 no 2404 0.381744375385321 3079 6384066
SGTC_546 peri-Naphthalide 147 µM -0.302016418413742 0.287138869524666 no 2405 0.381319773476368 2988 223824 A penicillin ester.
SGTC_621 3584-0052 32.1 µM -0.302051373345473 0.287128239814521 no 2406 0.381306450250786 3049 2273927
SGTC_3124 9127567 49.47 µM -0.306449174800653 0.285792367654913 no 2407 0.37963133600789 3158 17592030
SGTC_1237 0330-0133 46.1 µM -0.307846839056759 0.285368434270262 no 2408 0.379099439371589 2923 X1237 YHR072W ERG7
SGTC_352 k048-0007 5.11 µM -0.308322747727585 0.285224152125947 no 2409 0.37891837921985 3044 6811911
SGTC_392 N-ethylmaleimide 8.33 µM -0.308420375784816 0.285194558337975 no 2410 0.378881239764905 2991 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2659 sanguinarine 24.21 µM -0.308627299557559 0.285131838807174 no 2411 0.378802525966926 2936 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2492 derrusnin 100 µM -0.309186341799412 0.284962423459895 no 2412 0.378589891456106 2877 1715307 Part of coumarin class of compounds.
SGTC_2861 9024595 19.48 µM -0.309893576868037 0.284748167721566 no 2413 0.378320943724931 2987 16482810
SGTC_2934 9036370 36.88 µM -0.311150551175686 0.284367559221845 no 2414 0.377843086402093 3053 6462800
SGTC_2490 carminic acid 95.39 µM -0.311923881330683 0.284133517752898 no 2415 0.37754918633791 2922 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3183 9108214 49.47 µM -0.312711035744191 0.283895387141732 no 2416 0.377250105236007 3048 4974831
SGTC_2238 6671620 73.2395 µM -0.312782479604699 0.283873778614532 no 2417 0.377222963620625 2885 729941
SGTC_2306 7482397 179.52 µM -0.31312707846615 0.283769564147298 no 2418 0.377092058585765 3126 891448
SGTC_357 1325-0123 420 µM -0.314485287063497 0.283358989728353 no 2419 0.376576244634992 3081 1098503
SGTC_2461 5755302 26.15 µM -0.314651397226251 0.283308795652944 no 2420 0.376513175213755 3105 2788904
SGTC_1730 st033808 45.1 µM -0.315283155608008 0.283117934020695 no 2421 0.376273336595576 2948 1045166
SGTC_588 3970-1144 52.9 µM -0.315662322724609 0.28300341281472 no 2422 0.376129413804079 3078 1888707
SGTC_216 k038-0035 28.382 µM -0.316505161029374 0.28274892701873 no 2423 0.37580955421847 3056 4444231 YPR107C YTH1
SGTC_274 sirtinol 40.1 µM -0.316596894834389 0.282721235636733 no 2424 0.375774746117399 2996 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1507 4075-3230 155 µM -0.316685996687807 0.282694340000914 no 2425 0.375740937669817 2952 659771
SGTC_1619 st003326 88.7 µM -0.317525844530301 0.282440890084744 no 2426 0.375422316101146 3119 2849032
SGTC_2982 9019404 25.97 µM -0.317828771933178 0.282349499249661 no 2427 0.375307412306539 2975 22333232
SGTC_1002 4049-0206 172 µM -0.321537013747589 0.281231906158491 no 2428 0.373901733621194 2963 4662749
SGTC_478 N-arachidonylglycine 10 µM -0.321713081666678 0.281178895819061 no 2429 0.373835033287589 3060 5283389
SGTC_675 1309-0189 238 µM -0.321865699046185 0.281132949847464 no 2430 0.373777219848334 3017 4246530
SGTC_2321 7390090 138.78 µM -0.32227055769852 0.281011083371143 no 2431 0.373623867911501 3029 649046
SGTC_645 0845-0943 5.41 µM -0.324730230165776 0.280271246661629 no 2432 0.372692626576153 3024 1885106
SGTC_423 5-fluorouracil 457 µM -0.325696500984096 0.279980863613924 no 2433 0.372326995911628 2900 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1355 1499-0035 1.68 µM -0.326539516946888 0.279727640233698 no 2434 0.372008098054007 2975 1548538
SGTC_2342 7990637 118.86 µM -0.326820965951905 0.279643123918391 no 2435 0.371901650464101 3090 2033102 YER133W GLC7
SGTC_2399 5884133 200 µM -0.326914753938294 0.279614963079549 no 2436 0.371866180830515 2984 722445
SGTC_2886 9058944 51.95 µM -0.328341584415629 0.27918671193304 no 2437 0.371326702781442 3019 4949929
SGTC_1469 k284-2957 126 µM -0.328621339520911 0.279102783193787 no 2438 0.371220958258409 3016 23884841
SGTC_3082 9117008 49.47 µM -0.328672304185398 0.279087494713352 no 2439 0.371201695191338 3000 41448529
SGTC_2877 9040724 71.43 µM -0.329082963932794 0.278964319055674 no 2440 0.371046490285373 3177 6463895
SGTC_2627 acetyl isogambogic acid 100 µM -0.330541896626573 0.278526932332532 no 2441 0.37049527046156 3067 6857789 A caspase activator and apoptosis inducer.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.330582295067737 0.278514825670584 no 2442 0.370480010736383 3062 5379071
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.331112443561259 0.278355973780808 no 2443 0.37027977635061 3035 688761
SGTC_1078 idebenone 36.1 µM -0.331281209391158 0.278305414629822 no 2444 0.370216041728766 3059 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_652 0437-0092 114 µM -0.332567756895183 0.277920135774759 no 2445 0.369730292728456 3007 3091274
SGTC_898 1000-0849 28.3 µM -0.33288951973378 0.277823819050323 no 2446 0.369608840374464 3087 6751807
SGTC_2137 5261020 140 µM -0.332978225534957 0.277797268656679 no 2447 0.369575359837825 2977 763655
SGTC_67 0335-0847 266 µM -0.334636489638564 0.277301164422915 no 2448 0.368949657785853 3301 4552207 YOR254C SEC63
SGTC_347 4534-1311 26.2 µM -0.338292585168534 0.27620890046305 no 2449 0.36757135543227 2959 2862016
SGTC_656 4090-1979 187 µM -0.339084725888251 0.275972525840835 no 2450 0.367272952261733 3133 22330961
SGTC_2205 7238770 200 µM -0.339600591304492 0.275818645145178 no 2451 0.367078666388606 3130 279867
SGTC_3039 9090270 49.47 µM -0.342916854288046 0.274830424376916 no 2452 0.365830505915903 3148 17173750
SGTC_3065 9113888 49.47 µM -0.343993628441302 0.27450992974151 no 2453 0.365425538897364 3200 16648368
SGTC_803 4488-1585 147 µM -0.34444333857737 0.274376131137189 no 2454 0.365256450521843 3140 747204
SGTC_2948 9070189 9.45 µM -0.344912094059356 0.274236700399871 no 2455 0.365080229085231 3144 6473636 YDL196W YDL196W
SGTC_2269 7935389 174.42 µM -0.345165381735827 0.274161374858833 no 2456 0.364985021320285 2988 97605
SGTC_2457 5731572 11.68 µM -0.346320486932841 0.273817986304769 no 2457 0.364550936901724 3136 2865357
SGTC_2517 totarol 10 µM -0.346812816450582 0.273671691732511 no 2458 0.364365973961908 3113 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1226 3909-7979 35.4 µM -0.347196777485686 0.273557625447357 no 2459 0.364221745818771 3131 6615510
SGTC_1523 st012844 44.7 µM -0.348322132596578 0.273223443069291 no 2460 0.363799136980043 3137 4274103
SGTC_1696 st025591 34.7925 µM -0.351507346320753 0.272278668457089 no 2461 0.362603881057592 3030 2787147
SGTC_2241 6772625 37.8075 µM -0.351950739097406 0.272147281386645 no 2462 0.362437603104199 3026 2285411
SGTC_1738 st035555 74 µM -0.353663057192549 0.271640179778987 no 2463 0.36179570578701 3139 5331140
SGTC_1257 0669-0121 16 µM -0.353771570428878 0.271608059530703 no 2464 0.361755040466363 3102 4307855
SGTC_1863 st057641 20.1 µM -0.355861793882066 0.270989716335218 no 2465 0.360972034650721 3093 3921635
SGTC_490 phenamil 164 µM -0.356024299544822 0.270941672315164 no 2466 0.360911183752018 3086 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_956 1185-0240 191 µM -0.357635540492522 0.270465546748682 no 2467 0.360308038824169 3041 1416193
SGTC_1563 conessine 56.1 µM -0.358082637316321 0.270333502706839 no 2468 0.360140736069219 3130 441082 An anti-amoebic, histamine inhibitor.
SGTC_2724 maprotiline 69.64 µM -0.358450557129192 0.270224866708016 no 2469 0.36000308128338 3170 4011 A tricyclic antidepressant.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.358977520903138 0.270069307698317 no 2470 0.359805952865878 3124 279621
SGTC_84 0443-0269 128.823 µM -0.359411087958062 0.269941352880572 no 2471 0.359643790571207 3155 6150058
SGTC_142 0335-0849 62.6745 µM -0.359745284646595 0.269842745073927 no 2472 0.359518811919773 3167 3889043 YPR107C YTH1
SGTC_36 0335-0881 14.2 µM -0.359769973609618 0.269835461083728 no 2473 0.359509579649422 3064 23828853
SGTC_2785 7756463 72.73 µM -0.360294955805099 0.269680598776586 no 2474 0.359313285535125 3014 2201551
SGTC_1293 1000-1278 195 µM -0.361631493339887 0.269286540198977 no 2475 0.35881371350263 3174 678847
SGTC_2921 7974240 10.71 µM -0.361751332247713 0.269251221558852 no 2476 0.358768931804443 3161 2979074 YDR527W RBA50
SGTC_370 0180-0345 38.7 µM -0.36301991988977 0.268877488936886 no 2477 0.358295002006412 2947 3989527
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.365422881835425 0.268170278420716 no 2478 0.35739788163792 3020 6708514
SGTC_2611 pyromycin 23.93 µM -0.36551788496822 0.268142337502694 no 2479 0.35736242937682 3060 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2443 5493264 126.67 µM -0.366044236065239 0.267987561443288 no 2480 0.357166033571161 3195 5340055
SGTC_1186 1319-0216 26 µM -0.366464023236298 0.267864153269112 no 2481 0.357009426761981 3193 4565136
SGTC_2264 7948757 110.76 µM -0.367207429173354 0.267645678566988 no 2482 0.356732149080011 2993 2971411
SGTC_2267 7931562 200 µM -0.367468125468875 0.267569085516348 no 2483 0.35663493174356 2999 934880
SGTC_1836 st055642 81 µM -0.369236173081234 0.267049921661991 no 2484 0.355975847821367 3072 8571
SGTC_754 3474-0146 171 µM -0.370248908772863 0.266752774480645 no 2485 0.355598518925346 3023 24762078
SGTC_3301 9125354 19.7965 µM -0.372796813950923 0.266005932414327 no 2486 0.354649837149015 3042 41905162
SGTC_248 streptozotocin 5.23457 mM -0.373468341267369 0.265809270816645 no 2487 0.354399951805865 3150 5300 DNA alkylating agent.
SGTC_294 k038-0071 157 µM -0.373688703381361 0.265744752251709 no 2488 0.354317965422676 3112 24152826
SGTC_364 0083-0097 67.7 µM -0.375180811541149 0.265308095400914 no 2489 0.35376299991442 3187 5207356
SGTC_2950 9072895 21.46 µM -0.375458866883449 0.265226764386007 no 2490 0.353659616025159 3195 17332245
SGTC_2754 granisetron 64.02 µM -0.376275738003753 0.264987903336944 no 2491 0.353355957237103 3196 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2102 5377816 72.7585 µM -0.376540293127478 0.264910568287875 no 2492 0.353257633093928 3243 1379702
SGTC_2056 5235370 200 µM -0.37710318227851 0.264746062078263 no 2493 0.353048463189114 3075 5511916
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.377512724622366 0.264626404632192 no 2494 0.352896304936222 3161 17037758
SGTC_2602 kawain 100 µM -0.378400805911655 0.264367025295297 no 2495 0.352566434796435 3141 5369129
SGTC_1398 3558-0053 112 µM -0.37906491453818 0.264173145619242 no 2496 0.352319829790188 2996 4532369
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.380250549087336 0.263827191975856 no 2497 0.351879719737769 3199 5024745
SGTC_1294 1000-1494 117 µM -0.382858244827249 0.2630671118943 no 2498 0.350912436266175 3108 712797 YDL207W GLE1
SGTC_2030 5175110 200 µM -0.383047210382552 0.263012076532333 no 2499 0.350842379922978 3202 2831986
SGTC_1506 4226-2149 212 µM -0.383770053899499 0.262801605957707 no 2500 0.350574442589838 3172 991114
SGTC_729 4092-0585 94.1 µM -0.384608321865212 0.262557635125208 no 2501 0.350263813801288 3061 2169061
SGTC_2225 6654152 15.4 µM -0.384772379167835 0.262509901195654 no 2502 0.35020303239613 3139 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3170 9103054 49.47 µM -0.385907784503825 0.262179666727649 no 2503 0.349782482588028 3143 16432970
SGTC_1410 3909-8106 77.9 µM -0.387065103569669 0.26184327781395 no 2504 0.349354005617266 3179 1039210
SGTC_951 1171-0579 82.7 µM -0.387129319816548 0.261824619062267 no 2505 0.349330236299337 3068 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_809 3998-0021 90 µM -0.388276344099989 0.261491453197606 no 2506 0.348905770699559 3228 715485
SGTC_2866 9034245 58.44 µM -0.38828525655391 0.261488865329452 no 2507 0.348902473313364 3123 6462273
SGTC_251 melphalan 456.522 µM -0.388875702694792 0.261317449502748 no 2508 0.348684048362326 3153 460612 A DNA alkylator.
SGTC_599 1935-0052 86.5 µM -0.388895476163474 0.261311709952017 no 2509 0.348676734389975 3069 9557311
SGTC_3008 9078912 71.4286 µM -0.391077569743506 0.260678722157014 no 2510 0.347869949879421 3102 16648731
SGTC_3219 9131112 49.47 µM -0.393151247821927 0.260077915968365 no 2511 0.347103887486446 3193 17612988 YMR079W SEC14
SGTC_1915 st067105 30.6 µM -0.39365848505672 0.259931063009313 no 2512 0.346916597793901 3145 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2770 toltrazuril 17.5 µM -0.393854484576111 0.259874329600651 no 2513 0.346844237943875 3180 68591 Kills coccidiodes.
SGTC_422 cantharidin 155 µM -0.39423778776765 0.259763398320652 no 2514 0.346702744754863 3031 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2255 7941087 197.44 µM -0.395589978055943 0.259372257925575 no 2515 0.34620376580635 3245 935561
SGTC_2560 caryophyllene 100 µM -0.397748734509329 0.258748437971601 no 2516 0.345407704952144 3091 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2281 7943571 200 µM -0.39803313451324 0.258666312291096 no 2517 0.345302880760897 3325 1244024
SGTC_2458 5808907 16.39 µM -0.400009489117523 0.258095976852504 no 2518 0.344574763837666 3251 2731747
SGTC_1791 st048313 56.1 µM -0.400459952262129 0.257966073733994 no 2519 0.344408887292542 3203 1204976
SGTC_560 2332-1943 155 µM -0.401612433196456 0.257633879430366 no 2520 0.343984639102325 3135 21177716
SGTC_1039 k821-0043 94 µM -0.40551426544547 0.256510855724375 no 2521 0.342549767316226 3239 15992768
SGTC_372 0155-0182 15.9 µM -0.406713395028325 0.256166235749479 no 2522 0.34210925058801 3074 771486
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.407012699020905 0.25608025591134 no 2523 0.34199933062976 3260 5377381
SGTC_2802 7925815 54.55 µM -0.407551128770245 0.255925621294218 no 2524 0.341801624999234 3102 1262923
SGTC_3336 9143619 71.43 µM -0.408172615030803 0.255747193816033 no 2525 0.341573475844179 3253 45595730
SGTC_2634 4'-methoxyflavone 100 µM -0.408316410457171 0.255705919686664 no 2526 0.341520696425644 3176 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2476 5806916 10.51 µM -0.408419550921949 0.255676317042414 no 2527 0.341482841123335 3089 2870194
SGTC_2468 5987765 72.9 µM -0.409686453990667 0.25531284555995 no 2528 0.341017984089344 3149 26772094
SGTC_3036 9090181 49.47 µM -0.41158808289554 0.254767780152372 no 2529 0.340320683921709 3125 25236586
SGTC_2696 st077691 74.316 µM -0.413246290313605 0.2542929845537 no 2530 0.339713088137026 3273 757133
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.41413479708881 0.254038768840601 no 2531 0.339387695105464 3305 688751
SGTC_1631 benzylvanillin 81.9 µM -0.415905332025606 0.253532588885553 no 2532 0.338739638831078 3259 75506
SGTC_135 0933-0004 26.348 µM -0.416602556092825 0.253333404337701 no 2533 0.338484569700188 3250 21230617 YGL099W LSG1
SGTC_2716 st080858 38.6235 µM -0.41804944441352 0.252920316646325 no 2534 0.337955483460119 3263 5296050
SGTC_2592 piperlongumine 83.33 µM -0.420963447264612 0.252089443834134 no 2535 0.336890886770351 3189 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2862 9027634 71.43 µM -0.421410963822571 0.251961970617513 no 2536 0.336727507278295 3102 5012562
SGTC_2282 7944268 200 µM -0.424910323069919 0.250966366917756 no 2537 0.335451024504931 3339 2970414
SGTC_1849 st056239 19.2 µM -0.425403391527895 0.250826251397751 no 2538 0.335271317044989 3123 5393181
SGTC_2942 9052777 62.25 µM -0.425870794387798 0.250693467530507 no 2539 0.335100998660954 3180 6469503
SGTC_215 1287-0124 461.5 µM -0.426722835773521 0.250451508027794 no 2540 0.33479060788997 3171 5560863
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.428382250797252 0.249980629068318 no 2541 0.334186422427241 3178 65057 A dermal irritant. YDR527W RBA50
SGTC_1272 0839-0021 27 µM -0.428958497357002 0.249817222145948 no 2542 0.333976714039699 3231 5027250
SGTC_2586 curcumin 80 µM -0.429771732048887 0.249586708739664 no 2543 0.333680848827847 3247 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3317 9138495 8.753 µM -0.43058162764891 0.249357254156937 no 2544 0.333386301172717 3201 17020139
SGTC_1053 3366-3204 134 µM -0.432773893202237 0.248736718123548 no 2545 0.332589520661818 3182 3632071 YPR165W RHO1
SGTC_1953 st076800 12.1 µM -0.43333507819615 0.248578003095134 no 2546 0.332385678909083 3170 297591
SGTC_1992 st073643 23.3 µM -0.433517436026938 0.248526440046471 no 2547 0.332319450920256 3147 3161292
SGTC_132 0417-1715 25.805 µM -0.435007861858982 0.248105224643057 no 2548 0.331778360435774 3333 6769098
SGTC_2068 5226020 147 µM -0.435319065272564 0.248017322243787 no 2549 0.331665424061022 3197 1810509
SGTC_947 3447-0010 211 µM -0.43613768702661 0.247786174019117 no 2550 0.331368417575991 3241 748350
SGTC_2121 5257820 149.641 µM -0.436814215318996 0.247595234521283 no 2551 0.331123044431208 3295 791256
SGTC_173 1273-0061 2.693 µM -0.437792951228915 0.247319140826059 no 2552 0.330768190560207 3264 2847414 YPL266W DIM1
SGTC_3337 9144342 33.5465 µM -0.439242188668681 0.246910624824968 no 2553 0.330243029309307 3262 17682949
SGTC_504 lovastatin 124 µM -0.440178043280013 0.246647014952765 no 2554 0.329904080504078 3217 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_218 alverine citrate 93.75 µM -0.44109299494245 0.246389438777064 no 2555 0.329572837305572 3303 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3228 9131799 49.47 µM -0.442095183294985 0.24610746934863 no 2556 0.329210164885099 3230 17015818
SGTC_306 1672-3436 11.6 µM -0.442772415013605 0.245917025722124 no 2557 0.328965178875518 3269 6797378
SGTC_2644 guaiazulene 100 µM -0.442978094045636 0.245859202596272 no 2558 0.32889078980149 3266 3515 A coloring agent.
SGTC_945 3381-0768 11.3 µM -0.445580264024204 0.245128277820648 no 2559 0.327950234705193 3324 1126236 YIL048W NEO1
SGTC_469 w7 172 µM -0.44637719213406 0.244904662284197 no 2560 0.327662402581472 3265 45115570 A P450 inhibitor.
SGTC_2512 diallyl trisulfide 49.23 µM -0.446770114919097 0.244794449796907 no 2561 0.327520525570206 3272 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3159 9100096 49.47 µM -0.447924339442646 0.24447085119608 no 2562 0.327103900943413 3144 25236875
SGTC_2235 salicylic acid 500 µM -0.448686072329475 0.244257417927078 no 2563 0.326829066574686 3257 338 A COX inhibitor and kinase inhibitor.
SGTC_1022 4477-0945 21.3 µM -0.449202870273468 0.244112671264235 no 2564 0.326642658566654 3190 4648966
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.449419228281461 0.244052086659909 no 2565 0.32656463150305 3387 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1567 st069303 68.4 µM -0.450983114937723 0.243614408143655 no 2566 0.326000859293498 3283 5581319
SGTC_999 SEC7.066 22.7 µM -0.451370787527846 0.243505977410466 no 2567 0.325861166974218 3180 740511 YDR170C SEC7
SGTC_3004 9076122 71.4286 µM -0.451922080762094 0.243351827434753 no 2568 0.325662558373157 3316 44782551
SGTC_1407 3909-7909 12.3 µM -0.453077139633569 0.24302902646406 no 2569 0.325246597971834 3231 4411780
SGTC_2408 sulbentine 18.36 µM -0.453475230616128 0.242917826813948 no 2570 0.325103287645942 3171 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_873 0591-4978 488 µM -0.453733681194176 0.242845647972298 no 2571 0.325010260861949 3381 3305145
SGTC_1483 3453-0561 55.9 µM -0.4563382945835 0.242118892248153 no 2572 0.32407336522159 3285 4546991
SGTC_3216 9129716 49.47 µM -0.45717886117117 0.241884603978334 no 2573 0.323771245484914 3192 8056934
SGTC_2700 st077718 96.8 µM -0.457187427829754 0.241882216856018 no 2574 0.323768167020171 3247 904970
SGTC_2208 7283366 200 µM -0.457368617389413 0.24183173089497 no 2575 0.323703058615499 3307 898663
SGTC_375 3970-0961 9.27 µM -0.458814399156007 0.241429088748873 no 2576 0.323183726832668 3232 2898222
SGTC_744 1594-0068 283 µM -0.459091137645102 0.24135206016939 no 2577 0.323084360274508 3209 668392
SGTC_977 1348-1378 135 µM -0.45921355051384 0.241317991505826 no 2578 0.323040410366542 3179 X977
SGTC_574 1315-0397 40 µM -0.45975079121547 0.241168503222225 no 2579 0.32284755398927 3239 6794277
SGTC_2686 alizarin 95.37 µM -0.46079020169831 0.24087942816769 no 2580 0.322474566098625 3227 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2955 9076254 12.21 µM -0.46136308570314 0.24072018147146 no 2581 0.322269065513406 3294 16459619
SGTC_2962 9082311 13.18 µM -0.461484773780168 0.240686362763718 no 2582 0.32222542148486 3164 16459453
SGTC_322 k048-0136 19.3 µM -0.463851512642685 0.240029129617238 no 2583 0.321377066928626 3282 6823282
SGTC_421 streptovitacin 30 mM -0.463964702395819 0.239997721849301 no 2584 0.321336517497889 3355 91467 include heat shock
SGTC_155 k072-0202 43.6 µM -0.466810383068072 0.239208842356373 no 2585 0.320317773278774 3295 5857737
SGTC_1516 st013856 110 µM -0.469415141948714 0.238487995044599 no 2586 0.319386463596003 3292 5281404 A mutagen and neurotoxin.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.469945439373297 0.238341385084171 no 2587 0.319196999470068 3250 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2484 5809818 12.04 µM -0.47116763605868 0.23800367558186 no 2588 0.318760514138006 3245 2870548
SGTC_419 nsc-638432 893 µM -0.472433212579267 0.237654256254903 no 2589 0.318308801310945 3268 368090
SGTC_784 4579-0127 173 µM -0.472574784558839 0.237615186453185 no 2590 0.318258287856315 3401 1948547
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.473985663990513 0.237226016884933 no 2591 0.31775506515592 3248 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2504 purpurogallin 52.29 µM -0.474748487350743 0.237015749607585 no 2592 0.317483126670455 3202 5281571 An antioxidant.
SGTC_2591 skatole 100 µM -0.475160969232633 0.236902094352594 no 2593 0.317336122236914 3322 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_442 cape 100 µM -0.475452315723664 0.23682183480139 no 2594 0.317232306609601 3334 5281787
SGTC_1757 st041620 31.8375 µM -0.477280382932186 0.236318583873872 no 2595 0.316581239042031 3305 5289815
SGTC_2176 5809774 33.9695 µM -0.479579680273226 0.235686444345396 no 2596 0.315763148922827 3315 2870539
SGTC_524 r073-0010 27.8 µM -0.479717742108347 0.235648517084895 no 2597 0.315714055175132 3196 2772106
SGTC_2438 5259590 200 µM -0.481202052917663 0.235240971624533 no 2598 0.315186450974986 3302 1201127
SGTC_827 3253-0474 693 µM -0.482058827970208 0.235005905181742 no 2599 0.314882078285005 3356 5402065
SGTC_720 r052-1644 49.9 µM -0.483447408303158 0.234625207379083 no 2600 0.314389046679932 3336 1422863 YOR257W CDC31
SGTC_217 ketoconazole 989 nM -0.486009813509151 0.233923586094467 no 2601 0.313480104054036 3315 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1286 0929-0070 131 µM -0.488164183288308 0.233334591094042 no 2602 0.312716775946995 3369 1420408
SGTC_1015 4130-4525 82 µM -0.488275513084927 0.233304176406241 no 2603 0.312677351776473 3246 1363237
SGTC_1505 k297-0037 20.6 µM -0.489724834838746 0.232908430485345 no 2604 0.312164312817795 3244 4089396
SGTC_2771 fluoxetine 41.05 µM -0.489849019472664 0.232874538486176 no 2605 0.312120370171485 3404 3386 A selective serotonin reuptake inhibitor.
SGTC_2583 asiatic acid 100 µM -0.492795415249549 0.232071223471995 no 2606 0.311078575278101 3424 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2721 ifenprodil 61.44 µM -0.493817845913346 0.23179282557696 no 2607 0.310717414295867 3391 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1030 k029-0042 36.7 µM -0.495411159951232 0.23135935282579 no 2608 0.310154959335581 3304 6080581
SGTC_288 1315-0019 35.1 µM -0.495547929183236 0.231322164835843 no 2609 0.310106699167437 3374 6811474
SGTC_1721 st082152 9.2685 µM -0.49557274998035 0.231315416339472 no 2610 0.310097941292077 3311 5296051
SGTC_3149 9097855 49.47 µM -0.496748076678162 0.230995983934088 no 2611 0.30968335743042 3368 25236625 YMR079W SEC14
SGTC_95 0471-0001 561.058 µM -0.497449394032911 0.230805496006225 no 2612 0.309436090516385 3293 4015405
SGTC_394 menadione 8.33 µM -0.49818741055778 0.230605134825582 no 2613 0.309175977533896 3358 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_721 1187-1332 279 µM -0.498864367025712 0.230421436090988 no 2614 0.308937469167017 3270 25730
SGTC_1840 st055363 71 µM -0.499014011809319 0.230380839564127 no 2615 0.308884756505398 3310 676033
SGTC_1510 1123-0200 71.5 µM -0.499658563083801 0.230206027575312 no 2616 0.308657757084577 3474 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_297 0986-0032 24 µM -0.500429438631672 0.229997052013806 no 2617 0.308386364509042 3291 2847425
SGTC_2714 st079313 56.9 µM -0.501075678837214 0.229821945508672 no 2618 0.308158931401791 3295 2939799
SGTC_1847 st056231 15 µM -0.501193496650985 0.229790029410936 no 2619 0.308117475385819 3297 5393180
SGTC_1886 st057356 49.9 µM -0.501759982898405 0.229636606542409 no 2620 0.307918182645573 3251 24207747
SGTC_1112 tnp00069 1.16933 µM -0.502578972424626 0.229414899067049 no 2621 0.307630158115889 3355 145826
SGTC_618 k072-0232 33.2 µM -0.502613572005161 0.22940553530642 no 2622 0.307617992647007 3341 5872756 YGL099W LSG1
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.503496983818143 0.229166528193749 no 2623 0.307307450196872 3249 279621
SGTC_295 k015-0027 31 µM -0.503571995704743 0.229146240158366 no 2624 0.30728108790728 3342 3887424
SGTC_705 1124-0212 310 µM -0.503933092617179 0.229048590442164 no 2625 0.307154197405015 3406 9554485
SGTC_1387 3342-1166 1.8 µM -0.504012735552938 0.229027056125495 no 2626 0.307126213753675 3318 3418228
SGTC_812 4251-0442 148 µM -0.505008448804975 0.228757925318425 no 2627 0.306776450928032 3373 5723007
SGTC_545 4218-0007 221 µM -0.505139486102549 0.228722520541868 no 2628 0.306730434723498 3378 2840508
SGTC_470 aa-861 153 µM -0.505268890326366 0.228687560022624 no 2629 0.306684994992544 3316 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1772 st048439 82.2 µM -0.505403315141988 0.228651246291811 no 2630 0.306637795448666 3345 2927068 YDL195W SEC31
SGTC_3076 9116187 49.47 µM -0.506050553498129 0.228476445643625 no 2631 0.306410580559844 3345 27241210
SGTC_2153 5569715 200 µM -0.507227973967247 0.228158650498916 no 2632 0.305997434563086 3345 2054701
SGTC_1133 3473-0247 50 µM -0.508385877651674 0.227846365627393 no 2633 0.305591377390449 3280 711311
SGTC_626 0214-0009 33 µM -0.50849386779944 0.227817253114709 no 2634 0.305553519254359 3392 3437874
SGTC_2760 etidronate 98.04 µM -0.50854102665909 0.227804540455158 no 2635 0.305536987411942 3286 3305 A chelator and antioxidant.
SGTC_3272 9137413 49.47 µM -0.508653541517411 0.227774211328183 no 2636 0.305497546204079 3329 17614870
SGTC_2333 9017922 200 µM -0.510578394299465 0.227255706607562 no 2637 0.304823153962742 3392 3163164
SGTC_2360 9040895 200 µM -0.511535856314305 0.226998039445138 no 2638 0.304487943763662 3309 4914414
SGTC_1248 0469-0687 58.6 µM -0.51348078788431 0.226475137206076 no 2639 0.303807523233735 3385 4017482
SGTC_99 0109-0120 622.8 µM -0.513687610310974 0.226419572247144 no 2640 0.3037352077921 3457 759414
SGTC_538 2922-0838 53.3 µM -0.514033026351699 0.226326789865072 no 2641 0.303614450237397 3449 777039
SGTC_2179 6298986 200 µM -0.514654260782713 0.226159973820067 no 2642 0.303397320448669 3397 738374
SGTC_1177 0983-0204 23.6 µM -0.516391413937297 0.225693876341763 no 2643 0.302790530665074 3416 766818
SGTC_3299 9121982 43.1275 µM -0.516591682647739 0.225640176982832 no 2644 0.302720611504704 3320 17594604 YPL160W CDC60
SGTC_1260 0700-1617 7.75 µM -0.517219053437674 0.225472002754641 no 2645 0.302501626421917 3379 2853078
SGTC_862 0452-0056 10.2 µM -0.518051388367692 0.225248994990737 no 2646 0.302211207843944 3378 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1432 4049-0298 68.4 µM -0.519797174493658 0.224781652000094 no 2647 0.30160247444442 3392 741646
SGTC_1474 0330-0125 5.35 µM -0.520391338445099 0.224622721151021 no 2648 0.301395422907675 3410 X1474
SGTC_1531 st059297 52.4 µM -0.521318218556344 0.224374920539231 no 2649 0.301072555796538 3409 7566702
SGTC_57 miconazole 162.5 nM -0.521585897459939 0.22430338569838 no 2650 0.300979342210734 3361 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_773 4358-1457 44.6 µM -0.522880408845937 0.223957621645285 no 2651 0.300528739394603 3421 1186886
SGTC_3164 9100705 49.47 µM -0.524211758118931 0.223602334298547 no 2652 0.300065631824304 3452 17174235
SGTC_2985 9022375 71.43 µM -0.526200084932295 0.223072321500483 no 2653 0.299374597508059 3470 4939335
SGTC_2679 rapamycin 1 nM -0.527806019664788 0.222644762730838 no 2654 0.298816989325187 3387 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1949 st076024 69.1 µM -0.528190170323061 0.222542557006359 no 2655 0.298683675587126 3261 2921930
SGTC_1236 0330-0013 258 µM -0.529839168273978 0.222104134627017 no 2656 0.29811172293899 3330 4617066
SGTC_2713 st079149 53.4 µM -0.531093284484448 0.221771030559238 no 2657 0.297677068814039 3392 3103253
SGTC_2118 5526350 200 µM -0.531536384937876 0.221653407527327 no 2658 0.297523567329899 3382 743594
SGTC_1737 st035557 69.7 µM -0.531617570830741 0.221631860227439 no 2659 0.297495446349707 3345 5716916
SGTC_1288 0973-0013 65.5 µM -0.531939446044775 0.22154644409137 no 2660 0.297383967909698 3431 4315430
SGTC_786 4544-0069 423 µM -0.53278681456593 0.221321667608453 no 2661 0.297090581107022 3402 748821 YLR208W SEC13
SGTC_2228 7354201 200 µM -0.532950087773371 0.22127837207242 no 2662 0.297034065773572 3379 753451
SGTC_1336 1486-0901 104 µM -0.533343664865762 0.221174026235034 no 2663 0.296897853346682 3395 5006114
SGTC_40 0327-0103 19.753 µM -0.533815493498232 0.221048971324607 no 2664 0.296734596659629 3310 409036
SGTC_822 1487-0950 154 µM -0.53439866621318 0.220894461365726 no 2665 0.296532870796024 3440 1958375
SGTC_64 000l-0018 272.079 µM -0.534420838244137 0.220888588169243 no 2666 0.296525202486401 3375 6811119
SGTC_876 0720-0963 56.8 µM -0.53481645885502 0.220783806413805 no 2667 0.296388390364568 3463 765861
SGTC_480 am 92016 50 µM -0.535130693715325 0.220700600297544 no 2668 0.296279743399928 3384 2129 K+ channel blocker.
SGTC_2366 9070441 60.58 µM -0.536385744200783 0.220368455184034 no 2669 0.295845990913507 3335 6837235
SGTC_1965 Pectolinarigenin 58.4 µM -0.53834828449571 0.219849649931412 no 2670 0.295168311265651 3342 5320438 An anti-inflammatory.
SGTC_2992 9074591 71.4286 µM -0.539096566582431 0.219652023369094 no 2671 0.294910112279316 3445 17741321
SGTC_1004 4084-0029 199 µM -0.540528086102078 0.219274233387463 no 2672 0.294416448590882 3448 716894 YLR208W SEC13
SGTC_3162 9099653 49.47 µM -0.541258394900864 0.219081642738353 no 2673 0.294164746512622 3427 25237511
SGTC_2372 9071633 200 µM -0.541491577128223 0.219020170453577 no 2674 0.294084400837358 3448 21321366
SGTC_1339 1486-1321 22.7 µM -0.542551530995273 0.218740866903873 no 2675 0.293719309188177 3370 3469382
SGTC_3287 9117173 37.0625 µM -0.545447135333932 0.217978905295801 no 2676 0.29272301487971 3358 2789709
SGTC_1540 guanosine 70.6 µM -0.545540407128301 0.217954386828126 no 2677 0.29269094884086 3405 6802 Guanosine is a purine nucleoside
SGTC_2497 7-hydroxyflavone 100 µM -0.547337070819734 0.217482406132129 no 2678 0.29207359000036 3457 5281894
SGTC_2791 5663188 71.43 µM -0.547848063791893 0.217348276932963 no 2679 0.291898116421057 3455 54690634
SGTC_1427 4048-4900 550 nM -0.548151112300817 0.217268753098138 no 2680 0.291794073597639 3450 24132586
SGTC_791 1348-1292 225 µM -0.548230817041896 0.217247840338209 no 2681 0.291766712180968 3457 5437054
SGTC_1239 0337-0584 35.4 µM -0.551759224772915 0.216323229818076 no 2682 0.290556663555733 3509 914301 YML130C ERO1
SGTC_723 4182-0001 115 µM -0.551851894390497 0.216298976713123 no 2683 0.290524914675779 3367 744821 YLR208W SEC13
SGTC_2588 indole-3-carbinol 100 µM -0.553628058069255 0.215834430886927 no 2684 0.289916709846426 3467 3712 Induces cell cycle arrest.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.554854926693568 0.215513888074791 no 2685 0.289496946968392 3449 140250 A respiratory chain inhibitor.
SGTC_2968 9090663 33.37 µM -0.555065072919328 0.215459011078023 no 2686 0.289425075830329 3339 25236811
SGTC_416 estradiol valerate 100 µM -0.555526000399377 0.215338674157665 no 2687 0.289267465517078 3454 13791 A steroid.
SGTC_1171 0368-0077 21.4 µM -0.557814707470163 0.214741726435766 no 2688 0.288485459281898 3385 3239779
SGTC_1555 citronellol 128 µM -0.558817691290558 0.214480428385668 no 2689 0.288143073675731 3446 8842 A terpine precursor.
SGTC_2388 9080168 200 µM -0.558977196808489 0.214438890939755 no 2690 0.288088641425878 3374 15943073
SGTC_1898 st060199 18.6 µM -0.55953980963 0.214292416122138 no 2691 0.28789668505589 3443 688866
SGTC_2020 4017018 200 µM -0.560620004591594 0.214011353304709 no 2692 0.287528305611412 3447 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2129 girgensonine 121.053 µM -0.56154941789581 0.213769695156103 no 2693 0.28721152579505 3401 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_98 0074-0023 107.663 µM -0.562468597451562 0.213530854283458 no 2694 0.286898396601196 3434 3563821
SGTC_2692 st077426 47.7 µM -0.563723356689768 0.213205067083628 no 2695 0.286471209593967 3482 25238571
SGTC_2693 st077581 40.7 µM -0.564538692160215 0.212993527868471 no 2696 0.286193787766611 3471 25238761
SGTC_325 2810-4341 181 µM -0.565875024036649 0.212647080839505 no 2697 0.285739370550758 3488 774970
SGTC_1108 betulinic acid 729.144 nM -0.567219086590017 0.212298961772369 no 2698 0.285282671018767 3413 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_998 3996-0085 177 µM -0.567424607917003 0.212245760073119 no 2699 0.285212867512894 3413 715391
SGTC_2244 6635614 200 µM -0.567499136316064 0.2122264694146 no 2700 0.285187556610523 3268 836499
SGTC_3047 9092122 49.47 µM -0.568891039341065 0.211866382668283 no 2701 0.284715043376178 3418 17173831
SGTC_1906 st060206 94.7 µM -0.568985581671921 0.211841937440354 no 2702 0.284682962382878 3468 5133468
SGTC_1458 k015-0034 6.33 µM -0.569223853131823 0.211780336377886 no 2703 0.284602117524693 3424 3598957
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.570769824784289 0.211380906221867 no 2704 0.284077840040428 3330 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_570 0987-0065 62.6 µM -0.570862358044309 0.21135701255921 no 2705 0.284046474366463 3370 3104428
SGTC_3293 9120939 62.045 µM -0.571774676354878 0.21112152114559 no 2706 0.283737317757597 3485 934087
SGTC_989 1501-0895 10.3 µM -0.572079522350601 0.211042867312237 no 2707 0.28363405075651 3496 2830112
SGTC_1329 1447-1697 50.6 µM -0.575637509160528 0.210126135964066 no 2708 0.282430111135395 3467 2840515
SGTC_686 1319-0111 510 µM -0.575699936739923 0.21011007212648 no 2709 0.282409009060274 3544 4562600
SGTC_2978 9011784 42.97 µM -0.577242332318299 0.209713412721546 no 2710 0.28188788195645 3445 2994934
SGTC_2879 9041815 71.43 µM -0.578449797792993 0.209403195126695 no 2711 0.28148024083558 3445 4942971
SGTC_1023 4482-3888 16 µM -0.578470858201227 0.209397786760964 no 2712 0.281473133352513 3525 3303168
SGTC_2870 9038528 12.99 µM -0.578926797667492 0.209280720513685 no 2713 0.28131928377655 3480 6463316
SGTC_2355 9061122 103.12 µM -0.581073981093732 0.20872993142986 no 2714 0.280595296845312 3457 5302957
SGTC_1382 3002-2117 298 µM -0.581313436350833 0.208668560075441 no 2715 0.280514613273525 3542 1497314
SGTC_316 k060-0003 58.6 µM -0.581908355458814 0.208516130908138 no 2716 0.280314206076223 3513 6152314
SGTC_2055 5235184 200 µM -0.583070082402696 0.208218664548503 no 2717 0.279923061400454 3497 2836034
SGTC_89 0302-0250 142.109 µM -0.584151980252781 0.207941864158651 no 2718 0.279559032754136 3548 4203518 YLR208W SEC13
SGTC_3051 9093778 49.47 µM -0.584328800648476 0.207896645843962 no 2719 0.279499559449348 3467 17217378
SGTC_3343 9148379 18.9835 µM -0.584681401053333 0.207806492608363 no 2720 0.279380981116949 3534 1955036
SGTC_1064 honokiol 6.76 µM -0.585158449219396 0.207684557199668 no 2721 0.279220590328686 3460 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_922 1866-0035 480 µM -0.586256779496132 0.207403980353839 no 2722 0.278851485347904 3474 3156169
SGTC_2434 5670830 169.91 µM -0.588399956408764 0.206857135139255 no 2723 0.278131933502469 3473 1549830
SGTC_87 0100-0052 35.5 µM -0.589191064336017 0.206655494775377 no 2724 0.277866555356233 3564 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2829 7992743 58.44 µM -0.590061491331807 0.206433771832305 no 2725 0.277574712421311 3466 16462845
SGTC_3258 9138477 49.47 µM -0.590248231060432 0.206386222189275 no 2726 0.277512120519382 3531 4970355
SGTC_891 0929-0073 133 µM -0.59055904589936 0.206307093622825 no 2727 0.277407956100904 3507 5603632
SGTC_1846 st056244 14.8 µM -0.595430371420056 0.205069281636966 no 2728 0.275777914487173 3460 5393182
SGTC_283 0987-0079 11.7 µM -0.596324042734641 0.204842678379226 no 2729 0.275479386205928 3528 411556
SGTC_1043 0916-0009 19.3 µM -0.596835607952299 0.204713030677682 no 2730 0.275308570916179 3545 3101130
SGTC_1767 st044992 70.3 µM -0.596850512184875 0.204709254179555 no 2731 0.275303595067794 3458 9600693
SGTC_2295 7971645 200 µM -0.598228283953182 0.20436032749633 no 2732 0.274843810723706 3462 2978226 YKL099C UTP11
SGTC_2732 terfenadine 20 µM -0.601333160486329 0.203575303188056 no 2733 0.273809053634289 3496 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_864 0469-0573 172 µM -0.604649830303267 0.202738719719868 no 2734 0.272705844843758 3458 689425
SGTC_3207 9114163 49.47 µM -0.605847262919277 0.202437189553186 no 2735 0.272308090899141 3609 849233
SGTC_273 hydroxyurea 18.1 mM -0.606202083563653 0.202347892313462 no 2736 0.272190284693902 3556 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3261 9137475 49.47 µM -0.606811517163976 0.202194571960244 no 2737 0.271988001996861 3423 17027690
SGTC_745 0469-0705 296 µM -0.609314951365656 0.201565491402866 no 2738 0.271157849344262 3623 3486736
SGTC_1 0258-0098 57.368 µM -0.610520317173323 0.201263017288884 no 2739 0.270758594450996 3452 6790032 YDR047W HEM12
SGTC_3296 9122258 64.045 µM -0.610655858329903 0.201229021662802 no 2740 0.270713717339764 3518 4730474
SGTC_1798 st045719 60.953 µM -0.610901684982016 0.201167373670596 no 2741 0.270632334638715 3491 3980186
SGTC_769 0302-0231 76 µM -0.611449985671907 0.201029912558062 no 2742 0.270450859739329 3563 571869 YER009W NTF2
SGTC_1400 3771-8998 51.5 µM -0.611565689339943 0.201000912400063 no 2743 0.270412572261792 3492 670767
SGTC_654 1124-0271 80.9 µM -0.613175400034198 0.200597712245713 no 2744 0.269880184389929 3508 5403748
SGTC_432 NS 1619 61.3 µM -0.613327661806053 0.200559598890801 no 2745 0.269829853250034 3553 4552 A K+/calcium channel activator.
SGTC_1706 st031321 9.9705 µM -0.61381104020402 0.200438631005441 no 2746 0.269670100458731 3542 6103185
SGTC_2965 9082772 38.63 µM -0.614616825553693 0.200237076596683 no 2747 0.269403900044041 3595 16459634
SGTC_2928 9011484 9.79 µM -0.616023701221119 0.199885461084486 no 2748 0.268939438581964 3523 2994751
SGTC_134 0269-0018 6.916 µM -0.616208118603206 0.199839397836557 no 2749 0.268878585429312 3465 4378915
SGTC_668 1682-0499 62.6 µM -0.617432843861631 0.199533651476904 no 2750 0.268474632041731 3524 682214
SGTC_1766 st045414 44.774 µM -0.617930642115717 0.199409459221026 no 2751 0.268310529583959 3581 253960
SGTC_1229 0139-0193 12.2 µM -0.619149068264121 0.199105678892177 no 2752 0.267909080418028 3577 3090752
SGTC_1881 5652484 16 µM -0.61952763040859 0.199011351854716 no 2753 0.267784412728533 3523 2255129
SGTC_234 nsc-17383 10.7 µM -0.620043797276872 0.198882780988519 no 2754 0.267614476303661 3584 408974
SGTC_1928 4'-methoxychalcone 40.3 µM -0.62091926661925 0.19866482676788 no 2755 0.26732637190343 3614 641818
SGTC_728 3030-5151 22.5 µM -0.621294883089373 0.198571358592834 no 2756 0.267202809902674 3574 3125388
SGTC_1060 3448-7350 82 µM -0.621974998487513 0.198402186597289 no 2757 0.266979153950774 3527 570178
SGTC_1106 tegaserod maleate 11.7 µM -0.626293063900203 0.197330140692628 no 2758 0.265561367484375 3529 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2655 perillic acid 100 µM -0.626711474192803 0.197226448514197 no 2759 0.265424190571427 3515 5702197 An apoptosis inducer.
SGTC_2777 climbazole 1.536 µM -0.628100973287042 0.196882333648826 no 2760 0.264968897770482 3533 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_163 TUB2.036 7.546 µM -0.628582562734059 0.196763151025517 no 2761 0.264811189528915 3555 15992207 YJR013W GPI14
SGTC_3248 9135562 49.47 µM -0.62884442304968 0.196698364792539 no 2762 0.264725456997321 3593 17650701
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.630165977931674 0.19637159925795 no 2763 0.264292998099725 3548 6708739 YPR165W RHO1
SGTC_1361 1608-0041 5.61 µM -0.630332862598846 0.196330359034882 no 2764 0.264238413201331 3550 X1361
SGTC_3200 9114385 49.47 µM -0.631102664988693 0.196140194899624 no 2765 0.263986699370954 3566 17018030 YLR208W SEC13
SGTC_2675 theaflavin digallate 100 µM -0.631783434054274 0.195972117754646 no 2766 0.263764199965234 3559 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.631820856629376 0.19596288091564 no 2767 0.263751971717958 3552 260807
SGTC_1972 st070201 17.4 µM -0.632705875061704 0.195744512952594 no 2768 0.263462866286131 3568 2829099
SGTC_314 1671-0008 2.74 µM -0.632974634234972 0.195678229012987 no 2769 0.263375103831711 3515 3913060
SGTC_933 2914-0560 114 µM -0.634593941062439 0.195279148632213 no 2770 0.262846640409591 3594 463887
SGTC_3281 9140613 49.47 µM -0.637968888026121 0.194448979322656 no 2771 0.261746966406745 3529 16013766
SGTC_1107 amlodipine 47 µM -0.638620098476637 0.194289042209803 no 2772 0.261535051589407 3505 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_824 1304-0008 100 µM -0.639341547948921 0.194111947974387 no 2773 0.261300382697026 3582 768245
SGTC_718 1130-0073 349 µM -0.639946606651083 0.193963500029792 no 2774 0.261103656152288 3649 6740020
SGTC_866 0495-0101 262 µM -0.6405563340964 0.193813976637041 no 2775 0.260905488672364 3528 635694
SGTC_1996 st072960 66.8 µM -0.642017493105753 0.193455942824996 no 2776 0.260430912468477 3597 1719405
SGTC_817 1391-0715 46 µM -0.642779043150339 0.193269497135983 no 2777 0.260183741673882 3514 1353946
SGTC_2939 9044578 71.43 µM -0.644522351856236 0.192843106459378 no 2778 0.259618384089264 3563 2653634
SGTC_583 1488-1091 88.9 µM -0.64507752336541 0.192707439447419 no 2779 0.259438474386975 3658 4303273
SGTC_2076 5212012 200 µM -0.64599328473155 0.192483782735617 no 2780 0.259141852185282 3502 604802
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.646068197977274 0.192465493672515 no 2781 0.259117594964734 3653 688801
SGTC_2098 5376439 882.5 nM -0.647491587073805 0.192118194237314 no 2782 0.258656918816518 3627 2844116
SGTC_2246 7293507 91.5585 µM -0.647949715509628 0.192006494931613 no 2783 0.258508736999518 3593 887656
SGTC_1073 triclabendazole 3.09 µM -0.648271559191719 0.191928047881009 no 2784 0.258404662838316 3624 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_836 0330-0104 1.35 µM -0.648403318252984 0.191895938231127 no 2785 0.25836206235024 3604 46494820
SGTC_1827 berberine 7.24 µM -0.64990214061977 0.191530907105278 no 2786 0.257877717685987 3515 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1435 4092-0789 56.7 µM -0.651365430588731 0.191174940414266 no 2787 0.257405310244432 3611 2248285
SGTC_2278 7948257 134.34 µM -0.651408035935789 0.191164582120896 no 2788 0.257391562305846 3576 1247028
SGTC_9 0092-0002 10.449 µM -0.65446991401416 0.190421073674082 no 2789 0.256404552131276 3586 759368
SGTC_1660 st012960 28.1 µM -0.656918444281274 0.189827782742274 no 2790 0.255616678958489 3583 24207266
SGTC_1058 3448-5425 97.3 µM -0.658406927740461 0.189467672016585 no 2791 0.255138342497521 3548 7279705
SGTC_2018 5133068 143 µM -0.658502745249268 0.189444505173839 no 2792 0.255107566794578 3600 785362
SGTC_1301 naphtanilide LB 4.81 µM -0.659181545274018 0.189280434222817 no 2793 0.254889598080396 3648 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3088 9117578 49.47 µM -0.660506090026815 0.188960534014231 no 2794 0.254464555824226 3665 678341
SGTC_167 3672-0051 66.205 µM -0.660718929380312 0.18890916074915 no 2795 0.254396290994628 3582 3237971
SGTC_930 2810-3379 265 µM -0.661560722289116 0.188706060619182 no 2796 0.254126393416173 3661 1015764
SGTC_2286 7945697 125 µM -0.662028897790752 0.188593161763043 no 2797 0.253976350928449 3577 1245733
SGTC_2414 st077232 92.9 µM -0.663060873890819 0.188344451505941 no 2798 0.253645783927109 3582 729801
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.664968420076706 0.187885258403414 no 2799 0.253035345988345 3621 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_805 3852-0218 479 µM -0.666225584627652 0.18758300636032 no 2800 0.25263346103858 3590 6615355
SGTC_3097 9117246 49.47 µM -0.666509513710343 0.187514784716405 no 2801 0.252542742375076 3642 16423892
SGTC_2804 7954240 19.48 µM -0.666788606150104 0.187447740152237 no 2802 0.252453585805514 3620 828705
SGTC_1228 0124-0032 52.5 µM -0.668186090597471 0.187112254417323 no 2803 0.252007406537435 3656 X1228
SGTC_1865 st057639 52.2 µM -0.66836580155551 0.187069139248009 no 2804 0.251950059862263 3621 688818
SGTC_3315 9136395 68.55 µM -0.669704902310179 0.18674806380528 no 2805 0.2515229629862 3668 16876844
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.670800187309368 0.18648570169922 no 2806 0.251173914066315 3651 1273210
SGTC_2710 st078562 53.7235 µM -0.671047745284297 0.186426433863466 no 2807 0.25109505701173 3604 17250908
SGTC_2219 9098279 200 µM -0.671567520693229 0.186302032444259 no 2808 0.25092953051155 3625 902349
SGTC_1819 st053448 58.6 µM -0.67438278170535 0.185629130781148 no 2809 0.250033993306585 3587 2857616
SGTC_820 1582-0060 59.9 µM -0.675985337222464 0.185246763531974 no 2810 0.249524977289527 3619 3848840
SGTC_2 0422-0095 29 µM -0.677504432596316 0.184884761650211 no 2811 0.249042979328917 3537 6790840
SGTC_3015 9080845 49.47 µM -0.679025039968662 0.184522840073387 no 2812 0.24856099817688 3678 5296973
SGTC_748 act1.228 77.9 µM -0.679538956864073 0.184400621792876 no 2813 0.248398216318152 3610 4421505 YNR035C ARC35
SGTC_1413 3910-0535 34.4 µM -0.680666954548752 0.18413254116171 no 2814 0.248041125264114 3653 2876951
SGTC_1522 st012842 45.6 µM -0.684497182359209 0.183224058592695 no 2815 0.246830633998081 3576 3491067 YOR116C RPO31
SGTC_1817 st052116 64.4 µM -0.686085182494372 0.182848225808262 no 2816 0.246329697102798 3659 4361398
SGTC_920 mycophenolic acid 780.421 nM -0.690913885690522 0.181708373138563 no 2817 0.244809829703436 3672 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_717 1532-0246 73.2 µM -0.69317241121294 0.181176760121704 no 2818 0.244100679786915 3661 9561992
SGTC_1347 1493-0251 600 nM -0.694885822000847 0.180774107086297 no 2819 0.243563429283926 3697 3986378
SGTC_2558 carylophyllene oxide 100 µM -0.694991455224106 0.180749301558904 no 2820 0.243530328249056 3749 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_828 2074-0507 139 µM -0.696041585996624 0.180502818621375 no 2821 0.243201393365615 3710 X828
SGTC_2769 toremifene 3.73 µM -0.696844263017213 0.180314559379726 no 2822 0.242950131044734 3686 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2412 st077135 33.4 µM -0.698590886113759 0.179905333698342 no 2823 0.242403870506468 3722 13258915
SGTC_905 2-aminofluorene 215 µM -0.701956576425481 0.179118414544659 no 2824 0.241353122115477 3706 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2185 6113692 200 µM -0.705346529304142 0.17832801499712 no 2825 0.240297305519318 3666 874150
SGTC_1922 5578187 25 µM -0.705883080061482 0.178203114872334 no 2826 0.24013042526748 3706 1350412
SGTC_1143 3454-2408 5.08 µM -0.706519315425768 0.178055081295608 no 2827 0.239932622589681 3639 X1143
SGTC_1630 st005209 31.3 µM -0.711862496415867 0.176814938770542 no 2828 0.238274963911976 3681 3367314
SGTC_2050 5263056 171 µM -0.711991566528245 0.176785049528031 no 2829 0.238234999187341 3707 763468 YGL055W OLE1
SGTC_3251 9135047 49.47 µM -0.714232239178106 0.176266677774847 no 2830 0.237541792322523 3681 17682963
SGTC_2805 7950783 58.44 µM -0.714259870018915 0.176260291486503 no 2831 0.237533250961863 3720 1178958 YDL195W SEC31
SGTC_1302 1159-0335 255 µM -0.714428147699788 0.176221400797423 no 2832 0.237481235903426 3700 649284
SGTC_3021 9087658 49.47 µM -0.715494081942366 0.175975178685141 no 2833 0.237151898205275 3674 25237042
SGTC_1149 3909-7961 23.3 µM -0.716140291950159 0.175826015561164 no 2834 0.236952363361586 3689 735261
SGTC_1040 k898-0338 155 µM -0.716643952270548 0.175709812394311 no 2835 0.236796908610619 3717 20969351
SGTC_1009 4106-0057 9.87 µM -0.717456879204878 0.175522358727764 no 2836 0.236546117080207 3708 2928005
SGTC_663 1486-0733 13.9 µM -0.718315956114845 0.175324401090021 no 2837 0.236281246998028 3712 722445 YPR165W RHO1
SGTC_1365 1672-3266 55.4 µM -0.718376188605351 0.175310526991539 no 2838 0.236262682281042 3709 6415873
SGTC_2546 rhodinyl acetate 100 µM -0.71928011972541 0.175102396920514 no 2839 0.235984171253275 3670 6708682
SGTC_2647 atorvastatin 60.16 µM -0.719788470705319 0.174985418035997 no 2840 0.235827622297901 3696 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_628 1636-0253 16 µM -0.722639636809735 0.174330242905388 no 2841 0.234950654917093 3713 4456143
SGTC_2473 5854593 8.94 µM -0.723716747247669 0.174083137700102 no 2842 0.23461982469847 3644 2872951
SGTC_1125 tnp00248 1.32998 µM -0.724438603955646 0.173917657673517 no 2843 0.23439825352338 3822 24207736
SGTC_2665 lovastatin 100 µM -0.724438901054709 0.173917589586471 no 2844 0.234398162353795 3732 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1201 1889-3372 45.9 µM -0.724542601844 0.173893825214063 no 2845 0.23436634131181 3634 5392199
SGTC_1994 st072947 40.9 µM -0.726289351969311 0.173493845278831 no 2846 0.233830702804993 3752 5286565 YDL195W SEC31
SGTC_2797 7859098 81.82 µM -0.726502390038257 0.173445102806051 no 2847 0.233765421424194 3749 972681
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.727769224237683 0.173155434983619 no 2848 0.233377433387736 3720 688667
SGTC_3230 9131665 49.47 µM -0.728374797515329 0.173017076604742 no 2849 0.233192093270476 3649 15943720
SGTC_1655 st012546 55.1 µM -0.728791553615465 0.17292189916367 no 2850 0.233064589504598 3679 720985 YLR208W SEC13
SGTC_1379 2144-0755 36.5 µM -0.729397176152091 0.172783648481351 no 2851 0.232879372325368 3764 5392327
SGTC_1745 st081495 74 µM -0.729647626485929 0.172726496619285 no 2852 0.232802801155661 3658 13842402 YBL026W LSM2
SGTC_927 2425-1185 123 µM -0.733873156680644 0.171764063119646 no 2853 0.231513024293079 3712 730375
SGTC_435 c-PAF 6.7 µM -0.736898521036651 0.171077095222763 no 2854 0.230592031752326 3759 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1279 0874-0590 65.2 µM -0.736982531912875 0.171058044027978 no 2855 0.230566486101854 3770 3523074
SGTC_186 3455-3465 67.277 µM -0.738110620340985 0.170802358224343 no 2856 0.230223615271162 3694 755278
SGTC_846 0335-0850 148 µM -0.73916377640092 0.170563877014208 no 2857 0.229903776926057 3739 6819598
SGTC_2175 5807670 165.306 µM -0.742617875671048 0.169783212967152 no 2858 0.228856531456872 3692 241186
SGTC_255 tunicamycin 200.472 nM -0.743832492330736 0.169509241778315 no 2859 0.228488910131301 3719 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2288 7946289 167.31 µM -0.744373067537135 0.169387399900089 no 2860 0.228325403956257 3754 1246052
SGTC_1654 st012436 41.8 µM -0.750038790309226 0.168113768628392 no 2861 0.226615671332676 3711 4323132
SGTC_973 1325-0077 65.9 µM -0.750273129341263 0.168061223218354 no 2862 0.22654511133312 3787 2835149
SGTC_3354 9151612 71.43 µM -0.752017360090782 0.16767044971289 no 2863 0.226020309501137 3777 27261949
SGTC_2926 9010726 65.15 µM -0.753444740342541 0.167351098415093 no 2864 0.225591353022943 3775 2994293
SGTC_253 dyclonine 31.25 µM -0.754263024959469 0.167168198469893 no 2865 0.22534564993802 3826 3180 An oral anasthetic.
SGTC_532 1548-0774 215 µM -0.754839895396795 0.167039336004467 no 2866 0.225172526439564 3852 5932993
SGTC_612 0302-0167 22.4 µM -0.759317741388027 0.166041245024891 no 2867 0.223831253568541 3783 235821
SGTC_3320 9137005 35.139 µM -0.75991888749031 0.165907546350897 no 2868 0.223651535475712 3804 4908713
SGTC_2701 st077767 14.721 µM -0.760152845624993 0.165855531404803 no 2869 0.223581613751254 3764 5721188
SGTC_1815 st051655 58.2 µM -0.761286198448842 0.165603706982899 no 2870 0.223243071139684 3718 5984156
SGTC_1609 st001574 46.4 µM -0.761481656394013 0.16556030237403 no 2871 0.223184715619104 3783 3960012
SGTC_3153 9100258 49.47 µM -0.762709306614934 0.165287850975369 no 2872 0.222818389522608 3716 25236848
SGTC_1783 st039459 87.517 µM -0.762740725450378 0.165280882029063 no 2873 0.222809018761606 3883 729761
SGTC_358 0075-0058 9.45 µM -0.763592395722245 0.165092047261013 no 2874 0.222555091132498 3720 1069125
SGTC_2768 sulfasalazine 50.2 µM -0.764465357300429 0.164898636730739 no 2875 0.222294986772489 3781 5384001 An antioxidant and salicylic acid derivative.
SGTC_1494 4358-1428 177 µM -0.765562827433594 0.164655693105831 no 2876 0.221968234895704 3790 1564571
SGTC_1138 3761-0006 1.03 µM -0.766309270639044 0.16449058782222 no 2877 0.221746151720548 3747 12061087
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.767218555380263 0.164289608750335 no 2878 0.221475791209294 3784 689007
SGTC_21 0849-0113 22.993 µM -0.768771065035567 0.163946825948626 no 2879 0.221014614427391 3744 1560156
SGTC_1676 st018489 23.4 µM -0.769024982485917 0.163890807016278 no 2880 0.22093923995948 3831 3696235
SGTC_969 1313-0238 134 µM -0.770072032576814 0.163659939440218 no 2881 0.220628582450677 3794 5212874
SGTC_3295 9122362 53.5725 µM -0.770750387519504 0.163510479452282 no 2882 0.220427449646342 3820 4730473
SGTC_3226 9131256 49.47 µM -0.771485895524724 0.163348527284402 no 2883 0.220209489705652 3667 17178073
SGTC_793 0488-0545 106 µM -0.772133716081817 0.163205969435616 no 2884 0.220017617412384 3794 292548
SGTC_1605 st000082 49.1 µM -0.778210508161062 0.16187266248555 no 2885 0.218222461478884 3798 1114022
SGTC_967 1306-0166 352 µM -0.778930873656891 0.161715079156965 no 2886 0.218010218018413 3753 4437607
SGTC_2323 6148992 148.28 µM -0.778936482775979 0.161713852528288 no 2887 0.218008565853806 3796 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1641 st009299 47.1 µM -0.780985806407797 0.16126610258056 no 2888 0.217405421363734 3728 4046054
SGTC_374 0880-0231 82.3 µM -0.78256942121224 0.160920658256784 no 2889 0.2169400020863 3749 6833587
SGTC_2580 diallyl disulphide 81.36 µM -0.782896888026084 0.160849286076856 no 2890 0.216843832554759 3825 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1284 0929-0043 16 µM -0.783460110083731 0.16072657882144 no 2891 0.216678484752163 3792 1239883
SGTC_1246 0422-0085 105 µM -0.784054243734455 0.16059720323373 no 2892 0.216504141145967 3816 264295
SGTC_1804 st050076 49.1 µM -0.78463685408592 0.16047040297655 no 2893 0.21633325780564 3836 3895976
SGTC_518 1021-0119 62.6 µM -0.785565587650542 0.160268407183669 no 2894 0.216061015802231 3809 1097762
SGTC_2168 5727979 200 µM -0.785635813407783 0.160253140126776 no 2895 0.216040438422681 3749 695210
SGTC_1274 0865-0114 173 µM -0.787691882963947 0.159806572623107 no 2896 0.215438477306923 3827 870624
SGTC_2885 9057732 51.95 µM -0.788257857102737 0.159683789043254 no 2897 0.215272946445745 3835 6471414
SGTC_2756 carbadox 75.1 µM -0.793101133578353 0.158635603862192 no 2898 0.213859451223954 3839 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3127 9126946 49.47 µM -0.795708518358054 0.158073184279242 no 2899 0.213100737260672 3826 27243249
SGTC_1213 1315-0166 115 µM -0.800566564388388 0.15702878680912 no 2900 0.211691306864984 3906 768401
SGTC_3178 9107506 49.47 µM -0.802695674910715 0.156572497951014 no 2901 0.211075326708428 3868 8897194
SGTC_660 4031-1742 102 µM -0.802769069539659 0.156556784355758 no 2902 0.211054111408973 3758 6738706
SGTC_1271 0832-2808 169 µM -0.804587431040457 0.156167809503439 no 2903 0.210528898798306 3884 3663794
SGTC_1207 2099-0101 141 µM -0.804652533081004 0.156153895015648 no 2904 0.210510109063449 3873 5837381
SGTC_2819 7996655 46.38 µM -0.806709066853666 0.1557147653175 no 2905 0.209917059581357 3789 6456960
SGTC_2763 lisinopril 49.32 µM -0.809003164868587 0.155225870582935 no 2906 0.209256662916349 3764 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_857 0438-0306 1.35 µM -0.809291500500567 0.15516449519243 no 2907 0.209173747007069 3919 4686136
SGTC_1122 capsaicin 818.572 nM -0.810699539203243 0.154865008931642 no 2908 0.208769119021296 3953 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3009 9080819 71.4286 µM -0.813604883905784 0.154248257021791 no 2909 0.207935669564769 3876 17027216
SGTC_2272 7805186 180 µM -0.813612945216889 0.154246548014806 no 2910 0.207933359771687 3852 2956062 YPR165W RHO1
SGTC_2114 5491910 81.25 µM -0.818829613810217 0.153143234369112 no 2911 0.206441816260379 3934 2849228
SGTC_2507 purpurin 79.67 µM -0.821109909741924 0.152662603807099 no 2912 0.205791832941805 3871 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.822013707821469 0.152472382497321 no 2913 0.20553454765747 3863 688669
SGTC_1006 4099-6547 255 µM -0.82316239474892 0.152230846808595 no 2914 0.205207825328023 3909 3146833
SGTC_1256 0570-0116 285 µM -0.823484828651097 0.152163093956249 no 2915 0.205116170583449 3883 410638
SGTC_1895 st058434 18.3 µM -0.82400857053899 0.152053083054718 no 2916 0.204967344093087 3886 5393175
SGTC_438 sphingosine 6.67 µM -0.824766002090213 0.151894079580932 no 2917 0.204752225938779 3837 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1310 1188-0297 994 nM -0.826999759243213 0.151425802588897 no 2918 0.204118598970531 3785 1588352
SGTC_3052 9092717 49.47 µM -0.828754568335225 0.151058604574622 no 2919 0.203621650431386 3868 25237534
SGTC_2970 9090938 41.86 µM -0.831071630964134 0.150574662083745 no 2920 0.20296658241312 3911 17217104
SGTC_608 k048-0125 159 µM -0.832439524468187 0.150289448664699 no 2921 0.202580450127553 3911 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3061 glucosamine 200 µM -0.834212860114249 0.149920234533975 no 2922 0.202080522794876 3763 91431 and experimental redox chemotherapeutic
SGTC_2309 7664088 163.95 µM -0.834291094265345 0.149903959877981 no 2923 0.202058484545472 3876 704922
SGTC_1831 st055328 12 µM -0.835524391381729 0.14964755898427 no 2924 0.20171125974071 3844 1103068
SGTC_335 4077-0256 27.6 µM -0.841899052698937 0.148326942241062 no 2925 0.199922230317302 3885 3121989
SGTC_2670 beta-carotene 100 µM -0.842698320797715 0.14816191229564 no 2926 0.199698593283545 3807 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1456 k015-0012 13 µM -0.843109090373927 0.148077145914652 no 2927 0.199583717597613 3903 2989616
SGTC_2608 thymoquinone 42.66 µM -0.84439940258865 0.147811088308252 no 2928 0.199223128048802 3885 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2817 7995342 71.43 µM -0.844707048852164 0.147747700072058 no 2929 0.199137211452264 3895 18879975
SGTC_3084 9116877 49.47 µM -0.846459075060246 0.147387055100662 no 2930 0.198648347466361 3756 27241325
SGTC_319 1348-1596 45.5 µM -0.848742518245054 0.146917907007214 no 2931 0.198012290835287 3987 5380505
SGTC_1451 4152-0210 104 µM -0.84922532505249 0.1468188396614 no 2932 0.197877961944253 3865 659563
SGTC_522 1273-0010 11.6 µM -0.850621830205189 0.146532542462673 no 2933 0.197489729409906 4036 5705015
SGTC_2146 5545642 200 µM -0.851360190318461 0.146381322963006 no 2934 0.197284649383699 3874 825326
SGTC_1780 st038448 24.544 µM -0.852688223048055 0.146109599625495 no 2935 0.196916111763032 3970 728868 YDL195W SEC31
SGTC_3339 9145883 14.936 µM -0.85627417494796 0.145377586236417 no 2936 0.195923071208864 3836 2030670
SGTC_798 1287-0182 476 µM -0.857013358110713 0.145227001299282 no 2937 0.195718751098635 3903 1649755
SGTC_1691 st019933 84.6 µM -0.859261222839133 0.14476971578493 no 2938 0.195098206398058 3850 6176082
SGTC_874 0599-0792 117 µM -0.864457928010056 0.143716260151588 no 2939 0.19366819127855 3906 765305
SGTC_2930 9013230 14.89 µM -0.865375848899599 0.143530721743446 no 2940 0.193416266119395 3964 2995857
SGTC_2361 9034121 116 µM -0.866298633043263 0.143344363376415 no 2941 0.193163207859803 3929 6496917
SGTC_1602 st001878 87.6 µM -0.866867941542183 0.143229471755995 no 2942 0.193007185296852 3936 595405 YLR310C CDC25
SGTC_2377 9073351 62.6 µM -0.870657681632788 0.142466253076687 no 2943 0.191970545676284 3900 7337946 YHR072W ERG7
SGTC_235 0330-0087 5 mM -0.872276322981853 0.142141113521975 no 2944 0.191528825553385 3943 46494818 YHR062C RPP1
SGTC_735 3076-0345 636 µM -0.874073176016627 0.141780764871504 no 2945 0.191039202183317 3998 2888990
SGTC_1367 1812-0510 76.9 µM -0.874161421934809 0.141763083607637 no 2946 0.191015175899687 3977 1142582 YDR527W RBA50
SGTC_2960 9079389 5.97 µM -0.876107803524234 0.141373479427855 no 2947 0.190485715450674 3952 16457355
SGTC_2625 euphol 100 µM -0.878504916104424 0.1408946512524 no 2948 0.1898348855052 3980 6708538 A triterpene alcohol.
SGTC_1254 0550-0035 264 µM -0.880789398322823 0.140439346203085 no 2949 0.189215909483737 4032 15121435
SGTC_765 1319-0117 244 µM -0.880789784298903 0.140439269361246 no 2950 0.189215805009374 3904 3487746 YGL099W LSG1
SGTC_2065 5221596 34.26 µM -0.881252955469437 0.140347079749121 no 2951 0.189090461402357 3942 788581
SGTC_12 0849-0099 9.267 µM -0.882629637031095 0.140073307629485 no 2952 0.188718205159857 3845 6071388
SGTC_184 1494-0393 24.714 µM -0.885868633720352 0.139430620312479 no 2953 0.187844160037468 3942 3090647
SGTC_2751 anetholtrithion 17.25 µM -0.888196018760238 0.138970056930047 no 2954 0.187217659983413 3977 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_141 0443-0274 32.331 µM -0.889798405229343 0.138653565324876 no 2955 0.186787071532752 3997 1627241
SGTC_1714 st033236 13.627 µM -0.890696938452166 0.138476308670865 no 2956 0.186545888846005 3987 2916566
SGTC_907 3448-6986 75.5 µM -0.891459123003233 0.138326071076173 no 2957 0.186341455874766 3989 590582
SGTC_284 0988-0104 32.6 µM -0.893507160517065 0.137922923811701 no 2958 0.185792819623803 3945 4666532
SGTC_692 k241-0027 77.8 µM -0.896869777190711 0.137262747171185 no 2959 0.184894204436454 4015 3600480
SGTC_2223 6903751 107.57 µM -0.897891644335431 0.137062554078572 no 2960 0.184621659867852 3925 5598863
SGTC_1603 st002045 67.8 µM -0.89810894579965 0.137020008474588 no 2961 0.184563735113651 3964 5887985
SGTC_1950 st077106 7.18 µM -0.900929031235472 0.136468680445026 no 2962 0.18381302719111 3957 13831864
SGTC_1167 k781-0610 148 µM -0.90153758829939 0.136349906579986 no 2963 0.183651278893158 3985 4525169
SGTC_487 nimodipine 119 µM -0.903139899809082 0.136037517072838 no 2964 0.183225825077138 3891 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3345 9148410 3.559 µM -0.904293120859304 0.135812986473276 no 2965 0.182919996753559 3945 4903596
SGTC_2944 9067346 25.62 µM -0.908208672587452 0.135052528189833 no 2966 0.181883991458411 3941 6473075
SGTC_2374 9071832 200 µM -0.909851702828544 0.13473429872832 no 2967 0.181450361721128 3892 17381698
SGTC_2119 5528445 120.635 µM -0.912405346417173 0.134240719638461 no 2968 0.180777688064879 4001 791935
SGTC_479 n-linoleoylglycine 10 µM -0.913135858173969 0.134099751953046 no 2969 0.18058554663744 4007 6433346 An anti-infammatory.
SGTC_513 4245-1575 41.7 µM -0.915189865975243 0.133703932846014 no 2970 0.180045981908348 3903 719745
SGTC_902 1120-0002 2.07 µM -0.915669214663931 0.133611675316379 no 2971 0.179920208225062 3973 3280475
SGTC_779 1360-0071 233 µM -0.916836184305635 0.133387258303997 no 2972 0.179614244187415 4059 7566
SGTC_265 mycophenolic acid 32.932 µM -0.916904899782678 0.133374051891003 no 2973 0.179596238095693 4067 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_703 3875-0075 71.8 µM -0.917666757496725 0.133227690888354 no 2974 0.179396678158448 4029 2850814
SGTC_2878 9043973 25.97 µM -0.91772652114487 0.133216214329993 no 2975 0.179381029651786 4064 6465167
SGTC_3128 9127691 49.47 µM -0.918662405207775 0.133036582979963 no 2976 0.179136089836285 4060 41316314
SGTC_506 n9-isopropylolomoucine 153 µM -0.920392361052533 0.132704978499586 no 2977 0.178683879549779 4007 6610355
SGTC_2605 digitonin 300 nM -0.921531955410563 0.13248684803017 no 2978 0.178386382751777 4047 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1416 3966-0321 25.3 µM -0.922809991555094 0.132242512377722 no 2979 0.178053116501434 4023 582530 YLR208W SEC13
SGTC_2747 doxorubicin 7.63 µM -0.923635411572462 0.132084873321027 no 2980 0.177838085168303 3928 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2046 4110841 106 µM -0.923997788340232 0.132015707402959 no 2981 0.177743733648829 4005 44119630 YMR134W ERG29
SGTC_1330 1469-0054 61.8 µM -0.925467806975628 0.131735384945701 no 2982 0.177361310988711 4010 7102664
SGTC_63 0099-0242 26.702 µM -0.927305372304803 0.131385551810923 no 2983 0.176884002898481 4044 3898502 YLR359W ADE13
SGTC_280 3448-3607 3.04 µM -0.928182718451146 0.131218750305241 no 2984 0.176656398605591 3973 626179
SGTC_279 1273-0055 2.93 µM -0.92863028426083 0.131133715220309 no 2985 0.176540360836072 4017 2847562
SGTC_405 ebelactone b 50 µM -0.929185878792254 0.131028208228047 no 2986 0.176396382172171 3976 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2532 xanthone 78.9 µM -0.930072939411914 0.130859877668284 no 2987 0.176166660290863 4023 7020 An insecticide.
SGTC_1414 3917-0015 5.4 µM -0.930111498138458 0.130852564071121 no 2988 0.17615667904276 3954 6618702
SGTC_3328 9140624 29.0385 µM -0.93047276334163 0.13078405509041 no 2989 0.176063179918948 4045 4904392
SGTC_2300 7976697 71.57 µM -0.93293233531216 0.130318290063424 no 2990 0.175427452915457 3916 2236109
SGTC_3100 9120536 49.47 µM -0.93325165883103 0.130257904569113 no 2991 0.17534502403361 3846 16421196
SGTC_683 panaxydol 45 µM -0.933729633648262 0.13016755359092 no 2992 0.175221687443891 3992 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1556 plumbagin 1.48 µM -0.934385606628762 0.130043626456889 no 2993 0.17505250981094 3917 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_324 1315-0088 19.6 µM -0.934961056391494 0.12993497911901 no 2994 0.174904184741867 3976 6787421
SGTC_1024 4507-0395 26 µM -0.936079854311054 0.129723925252381 no 2995 0.17461603729976 4101 4201836
SGTC_260 nsc-65238 3.989 µM -0.938429413093136 0.129281469598152 no 2996 0.17401188812118 4002 3246252
SGTC_1725 st036284 20.55 µM -0.94024362530267 0.128940543803382 no 2997 0.173546304596501 4119 707914
SGTC_1422 4031-0024 15.5 µM -0.940426670964269 0.128906180621153 no 2998 0.173499373428864 3973 782427
SGTC_2681 menadione 3.18 µM -0.940624176415643 0.128869110025799 no 2999 0.173448743969075 4046 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3121 9125696 49.47 µM -0.940872051097101 0.128822595890974 no 3000 0.17338521593681 4084 1235365
SGTC_569 4130-2812 160 µM -0.941555580476491 0.128694390701693 no 3001 0.173210110308873 3820 743552
SGTC_2029 5175081 200 µM -0.948759016234457 0.127348670373738 no 3002 0.171371595314221 4007 1380876
SGTC_2391 6285546 200 µM -0.949692513002412 0.127174996839259 no 3003 0.171134257574745 4016 846083
SGTC_150 3970-0969 77.2 µM -0.954884348382204 0.126212082801572 no 3004 0.169818092835387 4132 6615640
SGTC_2220 6782180 200 µM -0.958084325623748 0.125621130142131 no 3005 0.169010119333128 3958 833803
SGTC_104 0074-0074 590.992 µM -0.958500147049573 0.125544480698831 no 3006 0.168905308685697 3825 3943124
SGTC_3179 9107801 49.47 µM -0.958617345112631 0.12552288317234 no 3007 0.168875775653213 4044 4818259
SGTC_1701 st028638 40.4 µM -0.958764879962746 0.12549569880017 no 3008 0.168838602695196 4041 3490878
SGTC_1222 0366-0074 1.18 µM -0.959635896732918 0.125335291341189 no 3009 0.168619248006594 4056 286520
SGTC_1552 6-methylflavone 10.6 µM -0.961404135995674 0.125010090711952 no 3010 0.168174502746313 3942 689013
SGTC_725 1497-0963 19 µM -0.962753487945054 0.124762325353183 no 3011 0.167835623662238 4139 3549977
SGTC_1492 4158-0558 28.5 µM -0.965171153594925 0.124319257020999 no 3012 0.16722954637311 4030 3967268
SGTC_3165 9101544 49.47 µM -0.968978407758192 0.123623761826723 no 3013 0.166277981248819 4068 5002184
SGTC_2441 5730946 39.09 µM -0.969764410605184 0.123480517691329 no 3014 0.166081968164188 4109 1774275
SGTC_2308 7584454 197.62 µM -0.970612874021672 0.123326021033888 no 3015 0.165870546312968 4124 893577
SGTC_1233 0325-0408 14.2 µM -0.971718016301451 0.123124988900557 no 3016 0.165595425679507 4095 12874
SGTC_591 4299-0174 154 µM -0.97238250441953 0.123004225078967 no 3017 0.16543014624095 4054 5509088
SGTC_2016 5121758 140 µM -0.973221869310812 0.122851797944792 no 3018 0.165221521958638 3992 2795203
SGTC_682 0kpi-0099 17 µM -0.977247882474001 0.122122522783614 no 3019 0.164223224009566 4096 1714895 YML126C ERG13
SGTC_431 k089-0097 107 µM -0.978113329379658 0.121966152827304 no 3020 0.164009138008322 3894 5499420
SGTC_3034 9090421 49.47 µM -0.978488083829499 0.121898485406306 no 3021 0.163916491029718 3925 17173761
SGTC_3096 9117468 49.47 µM -0.979091700959037 0.121789548921229 no 3022 0.163767335923641 3958 41316311
SGTC_1084 voriconazole 435 nM -0.981077018481472 0.121431735580383 no 3023 0.163277381229699 4080 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3007 9078383 71.4286 µM -0.981275306514075 0.121396038808103 no 3024 0.16322849827214 4059 6496995
SGTC_3002 9075603 71.4286 µM -0.987463390321677 0.120285736059592 no 3025 0.161707760814896 4010 20105405
SGTC_3029 9088683 49.47 µM -0.987720772094939 0.120239710569582 no 3026 0.16164470924956 4118 25236615
SGTC_489 paxilline 115 µM -0.988524308029533 0.120096100611005 no 3027 0.161447967825995 4075 105008 A toxic potassium channel blocker.
SGTC_1269 0831-0796 3.05 µM -0.991976056573726 0.119480570478913 no 3028 0.160604602733503 4108 927758
SGTC_2491 paeonol 100 µM -0.995570819772569 0.118841906882569 no 3029 0.159729359319325 3973 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3257 9139206 32.98 µM -1.00285086285757 0.117555893287891 no 3030 0.157966411877711 4086 4910041
SGTC_1646 st011709 75.6 µM -1.00590119524923 0.117019993932374 no 3031 0.157231550624051 4021 5757843
SGTC_2262 9014885 67.46 µM -1.00669848560065 0.116880207354855 no 3032 0.157039845054985 4052 6457424
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.00670734973123 0.116878653898389 no 3033 0.157037714571491 4114 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3313 9133968 57.047 µM -1.00960020187966 0.116372457322932 no 3034 0.156343436436097 4096 1494643
SGTC_540 1187-0821 17.3 µM -1.01161576024701 0.116020691799351 no 3035 0.155860903699625 4051 847520
SGTC_1821 st053465 65.6 µM -1.0132648051584 0.1157334540017 no 3036 0.155466846780231 4107 675086
SGTC_1686 st019653 115.5 µM -1.01412790661265 0.115583316765651 no 3037 0.155260861736929 4081 97252
SGTC_249 wiskostatin 11.211 µM -1.01744042310612 0.115008386436794 no 3038 0.154471980176546 4045 2775510 A n-wasp and actin depolymerizer.
SGTC_3277 9138724 49.47 µM -1.01907298902445 0.114725782776862 no 3039 0.154084158223554 4060 15943418
SGTC_2303 7774051 200 µM -1.02053207770249 0.114473627158198 no 3040 0.153738091986432 4158 2953184
SGTC_761 k216-0224 480 µM -1.02528878346087 0.113654326819579 no 3041 0.152613473340182 4156 1340404
SGTC_1001 4048-4355 44.4 µM -1.0300692730114 0.112835150217104 no 3042 0.151488744039163 4098 21824233
SGTC_837 0091-0265 12.5 µM -1.03008877903114 0.112831816355963 no 3043 0.151484166080512 4072 759367
SGTC_386 1509-0011 3.07 µM -1.03541673706819 0.111923822565758 no 3044 0.150237166321814 4132 3107280
SGTC_939 1165-0479 45.3 µM -1.0407613230043 0.111018256577053 no 3045 0.148993167290036 4124 1377347
SGTC_3095 9117207 49.47 µM -1.04425580885892 0.110429008811647 no 3046 0.148183526248404 4112 17015229
SGTC_1793 st048256 72.231 µM -1.04545613197943 0.110227126047549 no 3047 0.14790610265964 4021 672022
SGTC_2423 st077119 87.2 µM -1.04900231082126 0.109632239596307 no 3048 0.147088527434913 4067 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1796 st049173 110.4 µM -1.04940763172686 0.109564392378243 no 3049 0.146995273612896 4097 94134
SGTC_2199 6590217 200 µM -1.05492653483554 0.108643574470485 no 3050 0.145729462711683 4042 703109
SGTC_1604 st002052 72.4 µM -1.05522967628787 0.108593157678245 no 3051 0.145660147381342 4223 6254834 YHR062C RPP1
SGTC_3054 9094397 49.47 µM -1.05693583310359 0.108309713101989 no 3052 0.145270436656653 4149 2598354
SGTC_3069 9117009 49.47 µM -1.05814179500898 0.108109687550226 no 3053 0.144995401181041 4131 41904981
SGTC_90 0870-0863 4.608 µM -1.05842841492167 0.10806218679074 no 3054 0.144930085328115 4169 1738164
SGTC_2639 lactacystin 53 µM -1.05846428103707 0.108056243852335 no 3055 0.144921913438901 4210 3870 A proteasome inhibitor.
SGTC_3218 9131285 49.47 µM -1.05935202293176 0.107909221910966 no 3056 0.144719745390319 4122 17156417
SGTC_1640 st009078 66.4 µM -1.06083139384412 0.107664538448781 no 3057 0.14438326614127 4122 690618
SGTC_1325 1431-0015 227 µM -1.06331511226561 0.107254638333352 no 3058 0.143819537060971 4152 1103340
SGTC_959 1222-0044 107 µM -1.0664864084763 0.106732901020377 no 3059 0.143101909734204 4164 6083612
SGTC_3175 9106517 49.47 µM -1.06854522724378 0.106395168945655 no 3060 0.142637320260111 4175 41468073
SGTC_1519 esterone 74 µM -1.07034311824623 0.106100871653657 no 3061 0.142232446360967 4133 698 A steroid.
SGTC_73 0327-0325 16.231 µM -1.07849767784314 0.10477343200568 no 3062 0.140405858756337 4037 53298
SGTC_3326 9140064 16.379 µM -1.07935578034262 0.104634448310403 no 3063 0.140214577750027 4083 1868434
SGTC_3215 9129942 49.47 µM -1.08779290142654 0.103275025590375 no 3064 0.138343271991505 4161 17682944
SGTC_1371 2421-0008 32.7 µM -1.09229618496741 0.102554709071787 no 3065 0.137351468337599 4166 2827552
SGTC_2630 antimycin a 100 µM -1.09453566530479 0.102197858893804 no 3066 0.136860057044802 4132 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1340 1486-1359 257 µM -1.09691438956161 0.101819811041103 no 3067 0.136339408913074 4111 4309068
SGTC_1457 k015-0032 57.3 µM -1.09872004848241 0.101533520173375 no 3068 0.135945097483009 4188 4302660
SGTC_1795 st049545 62.3 µM -1.10076245540016 0.101210399532791 no 3069 0.135500028029372 4154 5291882
SGTC_925 2064-1272 59.6 µM -1.1030002191156 0.100857233279833 no 3070 0.135013534998919 4173 6815817
SGTC_2346 9031566 143.75 µM -1.10691541460809 0.10024149581397 no 3071 0.134165250341158 4182 4771086
SGTC_1096 rimcazole 32.2 µM -1.10709948608513 0.100212614825959 no 3072 0.134125458859372 4115 18528119 A dopamine reuptake inhibitor.
SGTC_62 0180-0423 3.232 µM -1.10762219331499 0.10013063468491 no 3073 0.13401250730865 4164 30102 YGL099W LSG1
SGTC_3105 9121040 49.47 µM -1.11332361012064 0.0992396160722587 no 3074 0.13278473492624 4088 41448907
SGTC_1283 0922-0125 16.4 µM -1.11425241107996 0.0990950137427731 no 3075 0.132585458273825 4203 3360884
SGTC_2518 prenyletin 46.28 µM -1.11470340898793 0.0990248547929091 no 3076 0.132488769851869 4178 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3071 9117417 49.47 µM -1.11536950743057 0.0989213004573602 no 3077 0.132346055400391 4164 45595590 YGL055W OLE1
SGTC_1740 st038286 13.222 µM -1.11833560546155 0.0984611407766504 no 3078 0.131711842746276 4256 716786
SGTC_1673 st016611 27.3 µM -1.11934048237623 0.0983056004236638 no 3079 0.131497455801987 4230 5226799
SGTC_2620 irigenin 100 µM -1.12284496315084 0.0977645659096251 no 3080 0.130751672706115 4242 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2571 chrysanthemic acid 100 µM -1.12901250186713 0.0968177057066642 no 3081 0.129446279917892 4223 2743 An insecticide.
SGTC_2572 astragaloside iv 100 µM -1.12904682154143 0.0968124557476901 no 3082 0.129439041329145 4262 45006101 An anti-inflammatory agent.
SGTC_2140 5586273 200 µM -1.12931358823392 0.0967716549648192 no 3083 0.129382785370577 4185 854421
SGTC_1163 k060-0048 49.9 µM -1.12964838920202 0.096720466511736 no 3084 0.129312206272014 4210 6809982
SGTC_1012 4112-3522 18 µM -1.13350561529526 0.0961321604756596 no 3085 0.128500992216031 4258 3112398
SGTC_727 3032-0951 202 µM -1.13533729212109 0.0958537152620608 no 3086 0.128117011391913 4262 3652836
SGTC_3329 9141233 27.5565 µM -1.13732012516903 0.0955529609700219 no 3087 0.127702242291528 4191 4909101 YNL103W MET4
SGTC_1958 st076513 41.9 µM -1.13732309827922 0.0955525105334319 no 3088 0.127701621077838 4177 732122 YGL099W LSG1
SGTC_696 1560-0013 611 µM -1.13808011458961 0.0954378707623746 no 3089 0.127543515377241 4281 1650269
SGTC_2520 obtusaquinone 4.71 µM -1.13886189773123 0.0953195866884893 no 3090 0.127380379941817 4275 5967872
SGTC_2793 7325131 81.82 µM -1.14158939615999 0.0949077603215927 no 3091 0.126812366866443 4191 4176441
SGTC_37 0566-0070 1.56 µM -1.14439480837638 0.0944855388557177 no 3092 0.1262299701498 4169 1626686
SGTC_2844 9010103 25.97 µM -1.15104201038648 0.093490649761636 no 3093 0.12485747646517 4258 2480525
SGTC_932 2857-0803 154 µM -1.15188259098726 0.0933653928879687 no 3094 0.124684661474197 4282 674898
SGTC_2433 5607874 27.82 µM -1.15445729077227 0.0929825023353676 no 3095 0.124156369390502 4210 2252428
SGTC_1312 1218-2183 165 µM -1.15453319698683 0.0929712317585998 no 3096 0.124140818305796 4297 6744073
SGTC_606 k015-0008 38.6 µM -1.15718955332023 0.0925774510080517 no 3097 0.123597462442985 4330 1970475
SGTC_842 0271-0008 11.1 µM -1.15928743678005 0.0922673318208247 no 3098 0.123169520489836 4282 1221709
SGTC_2095 5432005 200 µM -1.16696498716987 0.0911389549404395 no 3099 0.121612254711061 4253 783734
SGTC_2739 tacrine 100.86 µM -1.17096747476893 0.0905547791885455 no 3100 0.1208059255614 4318 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.17166130029699 0.0904537964771315 no 3101 0.120666533115682 4256 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2898 9056270 58.44 µM -1.17198870766775 0.0904061730777211 no 3102 0.120600794945995 4250 19154699
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.17229712755971 0.0903613285552322 no 3103 0.120538892227344 4129 4000243
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.17246497199583 0.0903369307691899 no 3104 0.120505213702837 4337 4213774
SGTC_2347 9049783 174.81 µM -1.17282928763245 0.0902839908584395 no 3105 0.120432135404318 4297 6467988 YPL169C MEX67
SGTC_1526 st051518 75 µM -1.17291689832639 0.0902712632960885 no 3106 0.120414566177627 4245 673993
SGTC_289 k017-0060 526 µM -1.17335734078231 0.0902072986156847 no 3107 0.120326268313147 4241 5512909
SGTC_2141 5621638 7.665 µM -1.17356813035929 0.0901766979320857 no 3108 0.120284026336159 4284 2856238
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.17628204795869 0.0897834023871231 no 3109 0.119741093523 4170 6708630 An antioxidant.
SGTC_1719 st032227 49.2 µM -1.17659373241581 0.0897383154499188 no 3110 0.119678850295498 4266 3125804
SGTC_883 0850-0245 24.6 µM -1.18122950407367 0.0890697102310235 no 3111 0.118755781779901 4339 6823229 YPR165W RHO1
SGTC_2745 rifampicin 24.3 µM -1.18233753472129 0.0889104522664205 no 3112 0.118535898937282 4326 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_810 3825-7150 143 µM -1.18297294530881 0.0888192199850158 no 3113 0.118409934937565 4331 22330411 YGL099W LSG1
SGTC_1658 st012944 20 µM -1.18866433843884 0.0880051558240077 no 3114 0.117285889533465 4123 24207260
SGTC_2892 9047358 58.44 µM -1.19008530696518 0.0878027792787118 no 3115 0.117006432306677 4284 6466771
SGTC_151 3013-0144 2.285 µM -1.19083064645719 0.0876967657645373 no 3116 0.116860037637543 4100 906558 YHR107C CDC12
SGTC_2986 9022445 71.43 µM -1.19092400378494 0.0876834937986571 no 3117 0.116841710160165 4279 6459286
SGTC_1638 st008370 60.6 µM -1.19216571498064 0.0875071107936163 no 3118 0.116598136933798 4231 24207134
SGTC_3001 9076041 71.4286 µM -1.19486776312538 0.0871242046207391 no 3119 0.116069349867698 4264 16004211
SGTC_2840 9008771 71.43 µM -1.19720156240165 0.0867944911118709 no 3120 0.115614000522273 4228 2992978
SGTC_1608 st001473 40.5 µM -1.19899728228974 0.0865414315229889 no 3121 0.11526450117825 4230 7292267
SGTC_1913 st060213 96.1 µM -1.20344074150963 0.0859176141587162 no 3122 0.114402904966071 4306 688959
SGTC_1888 azatryptophan 97.5 µM -1.20591552639068 0.0855716412629735 no 3123 0.113925031666729 4341 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1499 4480-0877 67.3 µM -1.20625416257578 0.0855243814577173 no 3124 0.113859752857226 4274 2861909
SGTC_2917 7979103 53.79 µM -1.2069334420151 0.0854296406750467 no 3125 0.113728888707257 4315 2980565
SGTC_1080 nisoldipine 24.4 µM -1.20873525806832 0.0851787177545351 no 3126 0.113382285727614 4288 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1261 0712-0010 12.7 µM -1.20905157949483 0.0851347235233433 no 3127 0.113321514971466 4299 2840123
SGTC_2073 5212005 126 µM -1.20934778748537 0.0850935421248751 no 3128 0.113264629418342 4164 691789
SGTC_2511 berberine 10.47 µM -1.21319613624033 0.0845598675453484 no 3129 0.112527420507787 4274 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_617 3770-0098 35 µM -1.21800083433711 0.0838970990065438 no 3130 0.111611827843687 4214 5962639
SGTC_181 1447-1644 8.07 µM -1.21842521801304 0.0838387468068433 no 3131 0.111531213392871 4278 534600
SGTC_2378 9074213 121.43 µM -1.21961023142112 0.0836759704125443 no 3132 0.111306332981253 4262 657714
SGTC_133 0724-0033 378.92 µM -1.22152474229316 0.0834134902680555 no 3133 0.110943701724519 4130 280309
SGTC_457 grayanotoxin iii 135 µM -1.22612012587848 0.082785987598585 no 3134 0.110076736609255 4151 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_444 curcumin 90.4 µM -1.2282904963374 0.0824908599139566 no 3135 0.109668968652705 4239 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1971 st069429 63.5 µM -1.22892129093221 0.0824052329906207 no 3136 0.109550658978967 4302 1246522 YGL099W LSG1
SGTC_1088 bifonazole 369 nM -1.23405744462778 0.0817105174457868 no 3137 0.108590749705509 4290 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3234 9132280 49.47 µM -1.23537743463512 0.0815326909376578 no 3138 0.108345033465962 4337 17612295
SGTC_2032 5185112 25.99 µM -1.2366920203719 0.0813558826812248 no 3139 0.108100721136159 4197 5718189
SGTC_1974 st069448 26.9 µM -1.23851530429607 0.0811111348370491 no 3140 0.107762525465232 4310 6323587 YNR016C ACC1
SGTC_1814 st052110 31.539 µM -1.24223456891256 0.0806136040513545 no 3141 0.107075014327674 4249 674163
SGTC_1659 st012954 42.1 µM -1.2474021652979 0.0799261588687497 no 3142 0.10612503650635 4278 24207262
SGTC_1808 st050063 61.5 µM -1.24833827522717 0.0798021038551725 no 3143 0.105953601476659 4313 4011993
SGTC_636 0kpi-0074 126 µM -1.25488603556458 0.0789384513180281 no 3144 0.104760067012385 4333 616434
SGTC_403 arphamenine a 50 µM -1.25592047995728 0.0788026577255813 no 3145 0.104572401241614 4307 5487158 An arginine aminopeptidase inhibitor.
SGTC_1467 k284-1082 293 µM -1.25844491649563 0.0784720129413329 no 3146 0.10411544820721 4304 3334705
SGTC_189 3970-0742 2.116 µM -1.25915568712872 0.0783791078858672 no 3147 0.10398705183214 4315 2891807
SGTC_1748 st037455 53.6035 µM -1.26298105697488 0.0778805243473878 no 3148 0.103297993767941 4372 580690
SGTC_1988 st071872 53.4 µM -1.28541680841856 0.0750046725177118 no 3149 0.0993233353256796 4375 16414116
SGTC_2144 5628481 200 µM -1.28992246652848 0.0744370217969354 no 3150 0.098538789707753 4342 2818399
SGTC_2395 5646831 180.19 µM -1.29167170447106 0.0742175279469514 no 3151 0.0982354302278978 4362 6808628
SGTC_3032 9089427 49.47 µM -1.29627788915142 0.0736419100386576 no 3152 0.097439881698549 4356 17173707
SGTC_411 enrofloxacin 100 µM -1.30207703276399 0.0729220735155218 no 3153 0.0964450267703151 4418 71188 A bacterial gyrase inhibitor.
SGTC_2011 4012611 177 µM -1.30837456119171 0.0721464870864767 no 3154 0.0953731483071643 4330 2049887
SGTC_2348 9022543 33.42 µM -1.30993635038338 0.0719551233911565 no 3155 0.0951086843705726 4386 3162678 YDL140C RPO21
SGTC_3080 9117754 49.47 µM -1.31069023407387 0.0718628905372616 no 3156 0.0949812197141889 4363 9550191
SGTC_393 acivicin 6.25 µM -1.31357586079986 0.0715106900766864 no 3157 0.094494488260352 4233 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1820 st053765 18.6 µM -1.31365632153495 0.0715008885887468 no 3158 0.094480942993831 4412 3690829
SGTC_778 3456-2434 196 µM -1.31499638085957 0.0713377980635014 no 3159 0.0942555594012355 4320 5539063
SGTC_1134 3477-0009 42.5 µM -1.31621919999779 0.0711892254397296 no 3160 0.0940502406153803 4432 3973534
SGTC_1395 3486-0190 4.35 µM -1.32078453503672 0.0706366354805085 no 3161 0.093286608839628 4352 6748079
SGTC_323 4013-0906 34.3 µM -1.32197778830028 0.0704927484593018 no 3162 0.0930877736845992 4405 2910086
SGTC_3107 9121808 49.47 µM -1.32305004367837 0.0703636441217763 no 3163 0.0929093681019075 4330 662681
SGTC_3111 9122088 49.47 µM -1.32366367655752 0.0702898418195323 no 3164 0.092807383522293 4272 16876704
SGTC_3254 9136651 49.47 µM -1.32976820969004 0.069558881199781 no 3165 0.0917973266061001 4342 16454030
SGTC_2439 5492030 7.2 µM -1.33946276995709 0.0684100953711575 no 3166 0.0902100333608144 4401 5722370
SGTC_367 0335-0881 7.1 µM -1.34329247612768 0.0679603374697226 no 3167 0.0895886437033937 4343 23828853
SGTC_2158 5657123 3.6195 µM -1.34588781173177 0.0676568434174061 no 3168 0.0891693500657075 4380 2858827
SGTC_2738 aclarubicin 5.55 µM -1.34689475320837 0.0675393757540126 no 3169 0.089007065798582 4421 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1309 pyrazolanthrone 13.4 µM -1.35636580585941 0.0664422021543138 no 3170 0.0874914036450825 4390 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2411 st077133 39.94 µM -1.35652592561961 0.0664237724221277 no 3171 0.0874659461344979 4393 1403142 YNL221C POP1
SGTC_892 0929-0076 29 µM -1.35811422717819 0.0662411737220657 no 3172 0.0872137207217891 4379 5751038
SGTC_746 1095-0025 46.6 µM -1.36369957830604 0.0656021413706022 no 3173 0.0863310684192421 4422 6749286
SGTC_2843 9000894 45.46 µM -1.36373887184711 0.0655976627024544 no 3174 0.0863248826178951 4373 2242070
SGTC_627 1391-0720 175 µM -1.37442810700163 0.0643880872870733 no 3175 0.0846544076401761 4382 997839
SGTC_1140 3229-1848 2.98 µM -1.38056714000817 0.0637012813634665 no 3176 0.0837060463449843 4412 2849525
SGTC_3118 9124250 49.47 µM -1.38359310069688 0.0633648548760185 no 3177 0.0832415410360297 4380 1504786
SGTC_1206 3978-0017 132 µM -1.38678721573358 0.0630112352097709 no 3178 0.0827533282661059 4479 3873677
SGTC_1208 2323-2347 50.3 µM -1.38789859359551 0.0628885559649473 no 3179 0.0825839630901202 4439 5412760
SGTC_1044 1222-0021 1.78 µM -1.39001608879001 0.0626553317600665 no 3180 0.0822619959311174 4342 4306703
SGTC_2127 5253358 187.912 µM -1.39042767745831 0.0626100770974749 no 3181 0.0821995233658952 4351 20612
SGTC_1891 st059073 26.2 µM -1.40570930671061 0.0609478105387441 no 3182 0.0799052311222372 4506 688754
SGTC_1561 5-methoxyflavone 52.9 µM -1.40809618352576 0.0606913212461028 no 3183 0.0795512954957129 4402 94525
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.40970727526507 0.0605186741369824 no 3184 0.0793130678147934 4406 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_339 3091-4833 71.4 µM -1.41084953609373 0.0603965006476868 no 3185 0.0791444923199088 4270 3240077
SGTC_622 1348-1566 26.3 µM -1.41379559932123 0.0600822875758129 no 3186 0.0787109630266329 4434 7340407
SGTC_2002 4023503 131 µM -1.42034160043696 0.0593887045923465 no 3187 0.0777541278151993 4428 4736863 YCR052W RSC6
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.4325969092666 0.0581070827637561 no 3188 0.0759865327684031 4400 1241132 A phosphatase inhibitor.
SGTC_739 1486-1183 203 µM -1.44518922648863 0.0568129580159316 no 3189 0.0742023708487698 4456 4346692
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.44685028576527 0.0566439573457414 no 3190 0.0739694297047309 4460 641818 YHR062C RPP1
SGTC_1560 lithocholic acid 53.1 µM -1.46704085934544 0.0546212332819987 no 3191 0.0711824703171371 4416 9903 A bile acid which acts as a detergent.
SGTC_2671 danthron 100 µM -1.46971820344102 0.0543573559609674 no 3192 0.0708190452398358 4476 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_32 0928-0142 34.1 µM -1.47160872486373 0.0541716356082687 no 3193 0.0705632840690001 4483 2244242
SGTC_153 4077-0274 519.67 µM -1.48064895179897 0.0532904773239093 no 3194 0.0693500718296545 4494 3121976
SGTC_2447 5741742 33.78 µM -1.4816678760754 0.0531918784521732 no 3195 0.0692143443412667 4540 1776504
SGTC_882 0843-0131 351 µM -1.48205305257536 0.0531546435319095 no 3196 0.069163089610212 4491 5425421
SGTC_1406 3909-7906 11.9 µM -1.49130001762111 0.0522669293003786 no 3197 0.0679413721623299 4528 X1406
SGTC_122 0236-0016 402.397 µM -1.49992938791406 0.0514491630134958 no 3198 0.0668163472608008 4495 6808838
SGTC_2415 st077333 57.7 µM -1.50210928770762 0.0512442020653485 no 3199 0.0665344433200916 4501 2766255
SGTC_2646 retinol 96.75 µM -1.50514126130636 0.0509602072207225 no 3200 0.0661438814066422 4498 445354 A vitamin A analog and teratogen.
SGTC_996 3970-0799 1.8 µM -1.50736824334033 0.0507524124033859 no 3201 0.0658581470262483 4477 6615648 YGL040C HEM2
SGTC_943 3253-1379 105 µM -1.51064829917375 0.0504475869451584 no 3202 0.0654390406447218 4477 668464
SGTC_2553 4-methylesculetin 85.09 µM -1.53293960642973 0.0484144532211952 no 3203 0.0626453680134482 4520 5319502
SGTC_315 k915-0449 187 µM -1.53593556228487 0.0481462666921576 no 3204 0.0622770925378402 4542 20970215 YNL149C PGA2
SGTC_1786 berberine 21.6 µM -1.53879050340105 0.0478918106438512 no 3205 0.0619277245128191 4425 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_869 0564-0080 44.1 µM -1.55131218719876 0.0467884645278502 no 3206 0.0604134438069029 4510 6843321
SGTC_10 0279-0212 42.575 µM -1.55167559048989 0.0467567503800886 no 3207 0.060369933056495 4542 39851 YBR002C RER2
SGTC_2296 7971656 126.45 µM -1.55727882121839 0.0462699368173069 no 3208 0.059702150735201 4519 666570
SGTC_97 0535-0701 19.132 µM -1.56062243157907 0.0459813853627948 no 3209 0.0593064314620096 4422 2832013 YGL099W LSG1
SGTC_1674 st016616 23.6 µM -1.5623415394463 0.0458335911715242 no 3210 0.059103775575209 4486 625830
SGTC_1509 1326-1131 80 µM -1.58662694621803 0.043786254645189 no 3211 0.0562985803923053 4528 768313
SGTC_1997 st073024 93.8 µM -1.58718265630234 0.0437402844161634 no 3212 0.056235640839321 4576 686268
SGTC_1162 k048-0130 20.1 µM -1.5872790277033 0.0437323162093459 no 3213 0.056224731490828 4536 6797406
SGTC_2196 6573537 42.6665 µM -1.58983967980049 0.043521024307226 no 3214 0.0559354735834171 4571 2903087
SGTC_291 SEC14.278 35.5 µM -1.59093076930585 0.0434312438928718 no 3215 0.0558125785033683 4554 1068044
SGTC_182 3448-4371 550.524 µM -1.5922792645121 0.0433204894761911 no 3216 0.0556609849564595 4473 3491403
SGTC_349 k015-0014 24 µM -1.5988308884604 0.042785633926214 no 3217 0.0549290918606529 4547 2196908
SGTC_699 0375-0592 111 µM -1.60622117295286 0.042188732110648 no 3218 0.0541126614288431 4610 762578
SGTC_2430 5571206 200 µM -1.60746044791799 0.0420893006804787 no 3219 0.0539766995348781 4530 1731771
SGTC_2352 9027995 87.8 µM -1.60916165251671 0.0419531159740916 no 3220 0.0537904995455368 4503 2997347
SGTC_611 3453-1652 23.7 µM -1.61499904911336 0.0414885310638578 no 3221 0.0531554503963372 4556 1560575
SGTC_2034 5197015 53.07 µM -1.61666789461893 0.0413564804862718 no 3222 0.0529749938331511 4551 780676
SGTC_2193 5925765 200 µM -1.62555206366506 0.0406592266077887 no 3223 0.0520224898855214 4582 877370
SGTC_210 3551-0445 56.827 µM -1.6259528431853 0.0406279986230933 no 3224 0.0519798437180825 4547 2865180 YOR207C RET1
SGTC_1787 fluconazole 80 µM -1.63387246319313 0.0400148998978603 no 3225 0.0511428164298195 4213 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2258 7960471 200 µM -1.63447141886366 0.0399688391002705 no 3226 0.0510799513955648 4563 2974708
SGTC_1882 5615643 20 µM -1.63974773811351 0.039564939407305 no 3227 0.0505288143214563 4554 2253075
SGTC_2313 7726885 200 µM -1.65164805472908 0.0386661572693531 no 3228 0.049303158861807 4564 726423
SGTC_672 1441-0018 53.7 µM -1.65610064261498 0.0383341775382042 no 3229 0.0488507196239318 4571 251141
SGTC_1048 3161-0300 24.5 µM -1.66086727306548 0.0379813624008101 no 3230 0.0483700531949912 4578 2165101
SGTC_3169 9102970 49.47 µM -1.67212126814112 0.0371588717298065 no 3231 0.0472502057661286 4633 17027839
SGTC_2931 9014674 55.67 µM -1.67661646613963 0.0368344373715056 no 3232 0.046808752382474 4527 2996810
SGTC_2078 5212016 200 µM -1.67847289367979 0.0367011299606856 no 3233 0.0466274089059635 4491 1899708
SGTC_3123 9126162 49.47 µM -1.67876122779773 0.0366804605473516 no 3234 0.04659929389043 4573 25239884
SGTC_418 lividomycin a 100 µM -1.68129090405956 0.0364995270312255 no 3235 0.0463532118998566 4602 72394 An antibiotic.
SGTC_567 1080-0542 68.4 µM -1.68721770032957 0.0360784754425668 no 3236 0.0457807495517296 4487 5950415
SGTC_551 k048-0028 34.9 µM -1.68790530198497 0.0360298853789788 no 3237 0.0457147043571457 4550 6836383
SGTC_115 0527-0192 112.043 µM -1.68848159530998 0.0359892023273625 no 3238 0.04565940951088 4548 4233931
SGTC_1813 st051246 8.6015 µM -1.68858091043278 0.0359821950433587 no 3239 0.0456498857442488 4553 5291959
SGTC_1861 st057647 17.4 µM -1.68948660373219 0.0359183444415497 no 3240 0.0455631084725195 4605 688668
SGTC_964 1287-0107 19.4 µM -1.69104729047465 0.0358085351595142 no 3241 0.0454138854918376 4569 51516812 YPR165W RHO1
SGTC_341 1486-1430 230 µM -1.69337879627083 0.0356450039103966 no 3242 0.0451916941303876 4547 2054753 YPL210C SRP72
SGTC_1751 st044839 27.194 µM -1.6950898305228 0.0355253822476766 no 3243 0.0450291905502749 4626 5291326
SGTC_193 1273-0060 1.558 µM -1.70083590654173 0.0351260694841095 no 3244 0.0444869023606701 4450 2847393 YHR072W ERG7
SGTC_1480 1070-0044 41.2 µM -1.70151608711704 0.0350790463385735 no 3245 0.044423059808365 4634 3124987
SGTC_2218 6965428 192.983 µM -1.70350574539209 0.0349417911235297 no 3246 0.0442367318660657 4506 675684
SGTC_653 0203-0016 55.2 µM -1.70529175723261 0.0348189600553684 no 3247 0.0440700120660084 4637 295302
SGTC_1045 1348-1485 165 µM -1.7145209666432 0.0341898678781432 no 3248 0.0432165448923521 4568 6810614
SGTC_169 k015-0017 16.025 µM -1.71998371656146 0.0338219320627477 no 3249 0.0427177007645912 4557 1840002
SGTC_635 k038-0028 24.7 µM -1.73169392373642 0.0330441782362326 no 3250 0.0416640365426237 4611 4035102
SGTC_2074 5212007 75.395 µM -1.73217071765132 0.0330128259972369 no 3251 0.0416215855176761 4547 758611
SGTC_3247 9135149 49.47 µM -1.74143608994304 0.0324084196188672 no 3252 0.0408035833648403 4633 8934436 YOR116C RPO31
SGTC_2233 sulbentine 40.3845 µM -1.74610389605799 0.0321074011892844 no 3253 0.0403964499701431 4618 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1148 3909-7663 27.7 µM -1.74694243016101 0.0320535709748325 no 3254 0.040323662400124 4627 4084526
SGTC_1381 2324-0066 62.1 µM -1.75519694580398 0.031527634224507 no 3255 0.0396128130754281 4614 10885928
SGTC_736 0958-0254 92.6 µM -1.76302812006797 0.0310352843897969 no 3256 0.0389478735384889 4659 6812352
SGTC_1875 nocodazole 6 µM -1.76553183573136 0.0308792231512539 no 3257 0.0387372123141699 4628 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2974 9094440 9.66 µM -1.77284288616161 0.0304272256523492 no 3258 0.0381273723970912 4590 25236134
SGTC_893 0958-0369 48.9 µM -1.77665297585775 0.0301938523124013 no 3259 0.0378126768457068 4485 6819948
SGTC_2428 5615643 7.78 µM -1.78074664924079 0.0299447645210955 no 3260 0.0374769242891982 4615 2253075
SGTC_2261 9010538 184.68 µM -1.78359306169111 0.029772575203165 no 3261 0.0372449069294147 4588 6457250
SGTC_687 k029-0044 34.9 µM -1.78953845869626 0.0294155667454487 no 3262 0.0367640697666858 4654 5829338
SGTC_676 falcarinol 140 µM -1.79589111631752 0.0290380384827299 no 3263 0.0362559177938089 4639 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_495 decylubiquinone 155 µM -1.79615577033912 0.0290223982864581 no 3264 0.0362348733880962 4621 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1581 himbacine 57.9 µM -1.79858622714687 0.0288790932258227 no 3265 0.0360420788085044 4641 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_477 mead ethanolamide 10 µM -1.8232589965397 0.0274573516415436 no 3266 0.0341320867019944 4644 16061185
SGTC_3242 9133940 49.47 µM -1.82630642719219 0.0272858664088682 no 3267 0.0339020588261 4634 17248444
SGTC_1501 4491-0275 38.4 µM -1.83020944569875 0.0270675411484948 no 3268 0.0336093129483139 4659 5104718
SGTC_1173 0443-0020 122 µM -1.83942932792951 0.0265575877604389 no 3269 0.0329260318759683 4630 5331295
SGTC_3194 9111903 49.47 µM -1.85177988677392 0.0258870763577538 no 3270 0.0320287184935813 4622 17087251
SGTC_3133 9127736 49.47 µM -1.85651430135509 0.025633828519355 no 3271 0.0316901432402117 4642 27243420
SGTC_1031 k035-0009 16 µM -1.85655123895681 0.0256318608793205 no 3272 0.0316875133698504 4675 5180959
SGTC_548 1436-0017 110 µM -1.85955840702454 0.0254720948002297 no 3273 0.0314740142731386 4668 9677137
SGTC_2339 9000433 200 µM -1.86674158164269 0.0250938368984526 no 3274 0.0309688419823706 4605 2988954
SGTC_51 1013-0126 23.419 µM -1.86943690583773 0.0249531242210283 no 3275 0.0307810270115802 4638 1627850
SGTC_3 0833-0587 95.581 µM -1.88754669410629 0.0240247383307901 no 3276 0.0295434160460007 4558 5382644
SGTC_2761 levamisole 97.89 µM -1.88828930289866 0.0239872969064652 no 3277 0.0294935612987377 4649 26879 An alkaline phosphatase inhibitor.
SGTC_691 1548-0686 185 µM -1.89327218707085 0.0237373322949226 no 3278 0.0291608409407364 4643 46495133
SGTC_29 0299-0004 12.984 µM -1.90061741210359 0.0233728579306713 no 3279 0.028676071573024 4596 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2001 4023502 57.655 µM -1.90964931696275 0.0229311561304803 no 3280 0.0280891903766627 4630 108941 YCR052W RSC6
SGTC_106 0092-0003 11.579 µM -1.91845347931005 0.0225073808247633 no 3281 0.0275267677484931 4619 1072148
SGTC_1583 clindamycin 39.6 µM -1.9198263419012 0.0224418989898539 no 3282 0.0274399191808064 4658 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2201 6605497 169.863 µM -1.92705803479418 0.0220996132482636 no 3283 0.0269861989122399 4642 670741
SGTC_2909 7941780 10.49 µM -1.92917947526609 0.0220000424492799 no 3284 0.0268542926396192 4635 1243215
SGTC_2479 5617353 43.85 µM -1.93621780679337 0.0216724036781914 no 3285 0.0264205152322421 4657 2731746
SGTC_2083 5306046 65.942 µM -1.94844547053239 0.0211130003110377 no 3286 0.0256808417668638 4673 539837
SGTC_2853 9015042 58.44 µM -1.95979523205166 0.0206047401350692 no 3287 0.0250098643821435 4597 6457456
SGTC_979 1426-2828 121 µM -1.96117768242053 0.0205435458263346 no 3288 0.0249291496630058 4705 747872
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.97455573194522 0.0199592790977477 no 3289 0.0241592934614259 4567 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.99649314753758 0.0190317188550671 no 3290 0.0229401354486393 4687 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2112 5488546 200 µM -2.00308246571813 0.0187603702384025 no 3291 0.0225842188548599 4666 600757
SGTC_110 0850-0284 111.64 µM -2.00325593184684 0.0187532715970387 no 3292 0.0225749124727997 4656 3906265
SGTC_2358 9037157 4 µM -2.01116426447618 0.018432062822695 no 3293 0.0221540545014829 4669 2388925
SGTC_156 3474-0145 5.642 µM -2.02097415641774 0.0180401413024418 no 3294 0.0216412202166732 4625 2265471
SGTC_2259 7964009 200 µM -2.02805583516539 0.0177616517941134 no 3295 0.0212772748636025 4700 313134
SGTC_2128 5255449 168.493 µM -2.03232438796683 0.0175955676159157 no 3296 0.0210604135549497 4619 736008
SGTC_327 1273-0057 3.96 µM -2.03250854369048 0.017588432268906 no 3297 0.0210510998697089 4636 3108138
SGTC_2075 5212009 200 µM -2.03525146846432 0.0174824461760994 no 3298 0.0209127883436317 4653 780898
SGTC_2941 9056145 11.23 µM -2.0469756434379 0.0170355513765329 no 3299 0.0203302380328472 4659 2119517
SGTC_670 4204-0025 119 µM -2.05940741377558 0.0165723877748262 no 3300 0.0197276130731434 4685 719039
SGTC_609 0986-0026 86.3 µM -2.06527325463437 0.0163576166172513 no 3301 0.019448576342679 4697 2848610
SGTC_420 mitomycin C 81.9 mM -2.06970727006177 0.0161968560174685 no 3302 0.0192398827679924 4685 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3027 9089541 49.47 µM -2.07058813417637 0.0161650808934758 no 3303 0.0191986509931637 4687 9943819
SGTC_1569 carminic acid 40.6 µM -2.08621646036702 0.015610142787545 no 3304 0.0184795099355756 4725 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1908 st060353 56.5 µM -2.10020197191674 0.015127478027903 no 3305 0.0178555389953434 4691 4227716
SGTC_2837 9008476 45.46 µM -2.10835780673514 0.0148519687194141 no 3306 0.0175000256031131 4672 2992805
SGTC_1341 1486-1360 280 µM -2.12630121474001 0.0142609808947391 no 3307 0.0167390934889368 4714 3976547
SGTC_815 1582-0027 36.9 µM -2.17483627831728 0.0127628892274935 no 3308 0.0148211937132872 4723 3128206
SGTC_2362 9071156 126 µM -2.19202265709602 0.0122660758849236 no 3309 0.0141889353403932 4702 653133
SGTC_624 k048-0052 28 µM -2.19203049498059 0.0122658531903579 no 3310 0.0141886523832461 4726 6835531
SGTC_2171 5739187 198.077 µM -2.19612213001356 0.0121500764758273 no 3311 0.0140416015064644 4696 2262761
SGTC_52 0329-0193 875 nM -2.22099661759439 0.0114664114306075 no 3312 0.013175595243329 4719 3739292
SGTC_2442 5158906 48.48 µM -2.22191879977764 0.011441721283079 no 3313 0.0131443968302637 4715 1893835
SGTC_1370 2001-0092 44.6 µM -2.22287024552817 0.011416296063321 no 3314 0.0131122753305599 4681 790957
SGTC_861 0443-0273 110 µM -2.23355816436445 0.0111340415492713 no 3315 0.0127560796057384 4711 6149169
SGTC_406 estrone 100 µM -2.2468419606328 0.0107917065414364 no 3316 0.0123250645170945 4719 5870 A steroid.
SGTC_1164 k060-0068 93.7 µM -2.26854895301483 0.0102520062022458 no 3317 0.0116478844381214 4738 5963676
SGTC_116 0155-0182 31.788 µM -2.32666239987261 0.00892140389925499 no 3318 0.00999162027902328 4641 771486
SGTC_3106 9121286 49.47 µM -2.3285518989226 0.00888080658680461 no 3319 0.00994140840048299 4711 15943471
SGTC_571 k831-0106 44.2 µM -2.36627927099108 0.00810341466385461 no 3320 0.00898394248784376 4692 4783639
SGTC_362 0310-0100 9.03 µM -2.43675048863246 0.00681016984317478 no 3321 0.00740995063246671 4753 790235
SGTC_100 0086-0128 49.5915 µM -2.44596675853576 0.00665529364562617 no 3322 0.00722321596362681 4737 93297
SGTC_102 gallobenzophenone 83.616 µM -2.45465197754451 0.00651219958822251 no 3323 0.00705105203605352 4749 70837
SGTC_299 1273-0059 1.44 µM -2.47326517608177 0.00621466818434219 no 3324 0.00669423792793805 4558 2848077
SGTC_2389 9091542 195.52 µM -2.47729614754335 0.00615184205200262 no 3325 0.00661910037717864 4739 3626624 YOL127W RPL25
SGTC_2803 7707263 71.43 µM -2.53000863997713 0.00538056871797345 no 3326 0.00570298589640532 4736 2199229
SGTC_1678 st019265 80.2 µM -2.53355090681931 0.00533196445542586 no 3327 0.00564566690328942 4744 5367020
SGTC_1050 3232-1156 69.3 µM -2.56690798338264 0.00489306974306287 no 3328 0.0051304918721236 4754 700529
SGTC_558 k064-0027 21.3 µM -2.5781373741928 0.0047527340354074 no 3329 0.00496672493259755 4767 5088526
SGTC_1921 5740136 50 µM -2.57825517508099 0.00475128108003589 no 3330 0.0049650319204712 4729 1774243
SGTC_689 0833-0039 98 µM -2.58360176134366 0.00468575189452702 no 3331 0.004888730932616 4738 5374726
SGTC_601 0986-0029 62.9 µM -2.58633696050857 0.00465254130589224 no 3332 0.00485010246635539 4739 24747981
SGTC_2130 NSC 7 2.4545 µM -2.59164337156835 0.0045887096633203 no 3333 0.00477593659273009 4763 21448
SGTC_2910 7948405 25.97 µM -2.63990876749001 0.0040430578729884 no 3334 0.00414641740828121 4771 2971328
SGTC_2139 5578692 56.4705 µM -2.64593593679436 0.00397916853590715 no 3335 0.00407326215133685 4770 650991 YMR113W FOL3
SGTC_2099 5377090 177.372 µM -2.72857801406275 0.00318989783853751 no 3336 0.00318040212786036 4784 2243829
SGTC_2138 5575593 77.673 µM -2.76040278737817 0.00292565089347477 no 3337 0.00288650681603036 4791 762213
SGTC_1938 st074717 56.4 µM -2.77049560722274 0.00284606782664812 no 3338 0.00279855275943793 4744 17250979
SGTC_337 1315-0038 354 µM -2.7845740067628 0.00273831882249789 no 3339 0.00267990441014433 4781 1626437
SGTC_2915 7971052 15.16 µM -2.78474987393038 0.00273699642916534 no 3340 0.00267845142611221 4772 5741558
SGTC_960 1222-0186 7.7 µM -2.95598573590447 0.00169171575927301 no 3341 0.00155835752310056 4769 3126296
SGTC_1954 st077032 68.9 µM -2.95944408557835 0.00167498410185611 no 3342 0.00154097312118122 4762 698907
SGTC_453 enantio-paf c16 10 µM -3.46927577183419 0.000351116608049603 yes 3343 0.000260931741822838 4488 13871343 A lipid and platelet activating factor
SGTC_118 0083-0097 135.343 µM -3.48856636858722 0.000329703131270379 yes 3344 0.000242809124282099 4784 5207356
SGTC_1634 st006576 41 µM -3.84394429672744 9.83892046347544e-05 yes 3345 6.05362491978497e-05 4799 3915356
SGTC_2563 tomatine 8.54 µM -4.54074155804347 6.96237181355698e-06 yes 3346 2.80283561264743e-06 4792 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_310 1273-0058 1.06 µM -4.87514337072478 1.71265191205896e-06 yes 3347 5.43647292138031e-07 4697 2734232