SGTCid condition conc unit CIA1|YDR267C.score CIA1|YDR267C.strain.pval CIA1|YDR267C.strain.significant CIA1|YDR267C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 7.67457690664553 8.82336464373623e-16 yes 1 8.29827628450434e-15 3 6708739 YPR165W RHO1
SGTC_178 4092-0806 87.505 µM 5.88097143222659 5.33516376317946e-10 yes 2 2.03932782503977e-09 12 2169044
SGTC_518 1021-0119 62.6 µM 5.49822646061898 5.89966411563498e-09 yes 3 1.91815029175495e-08 3 1097762
SGTC_2655 perillic acid 100 µM 5.40054404093923 1.06300536068258e-08 yes 4 3.32195486875161e-08 1 5702197 An apoptosis inducer.
SGTC_704 1310-0270 142 µM 4.52428684060086 1.34089406109421e-06 yes 5 3.02997462577146e-06 1 5718033
SGTC_2604 4'-hydroxychalcone 11.32 µM 4.28319005853395 4.4136223143967e-06 yes 6 9.21163354493345e-06 10 5282362
SGTC_208 k072-0098 12.366 µM 4.1491011134341 8.34241554292924e-06 yes 7 1.66891681096622e-05 17 5948901
SGTC_808 0711-0032 135 µM 3.97235073776667 1.87713018287404e-05 yes 8 3.5583414839974e-05 9 4252555
SGTC_2261 9010538 184.68 µM 3.94964465784695 2.07840790400302e-05 yes 9 3.91336492121936e-05 4 6457250
SGTC_2451 5856223 45.7 µM 3.94595239071814 2.11301430449073e-05 yes 10 3.97417036311779e-05 11 2179896
SGTC_3016 9080866 49.47 µM 3.62407925750867 8.44936801205888e-05 yes 11 0.000144996337504839 5 17066299
SGTC_2009 4012297 12.05 µM 3.51260028382173 0.000133230129518968 yes 12 0.000221872253842306 12 45595307
SGTC_2549 cedrol 20.94 µM 3.50082846794585 0.000139690558611584 yes 13 0.000231907136669956 18 6708665 A sedative which affects the nervous system.
SGTC_1049 3226-0134 66 µM 3.47499579869859 0.000154910541784907 yes 14 0.000255430675974652 11 5702385
SGTC_517 1365-0151 113 µM 3.45725282549905 0.000166249151696907 yes 15 0.000272856302306413 8 768657
SGTC_2205 7238770 200 µM 3.39143667498191 0.000215450922157829 yes 16 0.000347636139618123 3 279867
SGTC_1678 st019265 80.2 µM 3.35262083844789 0.00025052784787436 yes 17 0.000400251442458082 10 5367020
SGTC_57 miconazole 162.5 nM 3.33306542549318 0.000270151911630837 yes 18 0.000429473706375764 33 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_147 4466-0538 29.23 µM 3.31955865775018 0.000284532314438338 yes 19 0.000450799306220634 20 6742687 YHR072W ERG7
SGTC_2992 9074591 71.4286 µM 3.31422422408385 0.00029040568404441 yes 20 0.000459488906269185 7 17741321
SGTC_2596 sinensetin 100 µM 3.31236502430491 0.00029247910667518 yes 21 0.000462553771868469 13 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2675 theaflavin digallate 100 µM 3.30180363013807 0.000304521291398436 yes 22 0.000480326494525374 16 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2721 ifenprodil 61.44 µM 3.27900776050589 0.000332102714867706 yes 23 0.000520863855610238 12 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_519 k048-0011 62.8 µM 3.22110031023497 0.000412953765654259 yes 24 0.000638497220089559 17 6836379
SGTC_1956 st077085 54 µM 3.2173507678431 0.000418772450827056 yes 25 0.000646901570677487 8 24208685
SGTC_3324 9138759 60.749 µM 3.20165411568398 0.000443966305293662 yes 26 0.000683204800591484 9 45595710
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 3.1912900728785 0.00046136354157238 yes 27 0.00070819499355635 10 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3008 9078912 71.4286 µM 3.14772664627076 0.000541622883012165 yes 28 0.000822727444254449 8 16648731
SGTC_1660 st012960 28.1 µM 3.10887758338913 0.00062389831810447 yes 29 0.000938997559436474 6 24207266
SGTC_2661 dactinomycin 12.96 µM 3.094500461765 0.000657167068011731 yes 30 0.000985723139091453 6 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2830 7992007 71.43 µM 3.07915879390406 0.000694467676144541 yes 31 0.00103793002095814 17 1952075
SGTC_1731 st035964 63 µM 3.0564288592846 0.000753331725214101 yes 32 0.00111995313503109 22 6739575
SGTC_2456 5770359 74.46 µM 3.02484802459573 0.000842764013019053 yes 33 0.00124379044989465 13 3118787
SGTC_1023 4482-3888 16 µM 2.98309865283406 0.000975993290315479 yes 34 0.0014267300151034 18 3303168
SGTC_35 0133-0054 64.071 µM 2.97775530827192 0.000994374777246875 yes 35 0.00145183848938183 28 99677
SGTC_851 0394-0702 453 µM 2.96320996356379 0.00104603333403569 no 36 0.00152224411425944 36 762646
SGTC_2882 9058044 58.44 µM 2.95239874292938 0.0010860122040897 no 37 0.00157657732893019 19 18076804
SGTC_612 0302-0167 22.4 µM 2.94354281077264 0.00111979899221782 no 38 0.00162239471194199 17 235821
SGTC_1501 4491-0275 38.4 µM 2.87646936435389 0.00140866826510091 no 39 0.00201075615272638 12 5104718
SGTC_584 0986-0246 15.4 µM 2.87629050607762 0.00140952214057324 no 40 0.00201189597739389 53 53315 YDR232W HEM1
SGTC_2379 9035213 200 µM 2.83859597429585 0.00160039292819713 no 41 0.00226562452126564 17 646551
SGTC_2926 9010726 65.15 µM 2.8122475745055 0.00174749074000839 no 42 0.0024598310487019 20 2994293
SGTC_363 0455-0021 3.06 µM 2.79762596897415 0.00183432990837178 no 43 0.00257398443528595 39 4597466
SGTC_2278 7948257 134.34 µM 2.78537541836484 0.00191008825633518 no 44 0.00267328904994421 13 1247028
SGTC_3161 9100388 49.47 µM 2.78448530926095 0.0019157020294202 no 45 0.002680637483494 20 25236368
SGTC_696 1560-0013 611 µM 2.76378034758812 0.002050588168565 no 46 0.00285679934391036 29 1650269
SGTC_2248 tofa 1.1 µM 2.76056360644571 0.00207230105188823 no 47 0.00288508603369167 52 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1784 st039334 36.3 µM 2.75640882416958 0.00210065435210612 no 48 0.00292199514450174 29 3496984
SGTC_1181 1222-0449 220 µM 2.75208857491277 0.00213050962406087 no 49 0.00296082510075057 16 658318
SGTC_1993 st073995 70.8 µM 2.71583812323778 0.00239658761838141 no 50 0.00330541163516893 21 3098394
SGTC_1208 2323-2347 50.3 µM 2.69552636131894 0.00255849048873233 no 51 0.00351387583460849 6 5412760
SGTC_1056 3448-1962 115 µM 2.68886323306617 0.00261371638653935 no 52 0.00358478934511045 21 715507
SGTC_2666 tannic acid 100 µM 2.66164796205188 0.00285063952271779 no 53 0.00388795783938206 36 16134267 A thiamine antagonist.
SGTC_623 k072-0108 16.9 µM 2.63959409933659 0.00305665258399596 no 54 0.00415026880658692 39 5382803
SGTC_2900 5328528 85.29 µM 2.62339116696856 0.00321645328231497 no 55 0.00435296272532439 24 795359
SGTC_2006 4011487 200 µM 2.60194676274983 0.00343949418826542 no 56 0.00463481203031773 45 45595294
SGTC_433 pimozide 108 µM 2.59513284882078 0.00351321969467947 no 57 0.00472771819488574 9 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1734 st037168 69.4 µM 2.58342521848833 0.00364321427151106 no 58 0.00489123359257838 21 708907
SGTC_2490 carminic acid 95.39 µM 2.54976470132344 0.00404133919866873 no 59 0.0053897822557701 31 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2526 patulin 37.61 µM 2.52329908981973 0.00438125448079294 no 60 0.00581297363325068 37 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1852 st056254 31.4 µM 2.50593673535353 0.00461790800573738 no 61 0.00610637347014882 13 442583
SGTC_3 0833-0587 95.581 µM 2.48696967729898 0.00488941320828896 no 62 0.00644181898878231 47 5382644
SGTC_2513 baicalein 25.65 µM 2.48526809679664 0.0049144525096301 no 63 0.00647269505528469 19 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1571 st070080 73.4 µM 2.47522567112615 0.00506457060894623 no 64 0.00665760053539931 22 4315245
SGTC_1261 0712-0010 12.7 µM 2.45402749520123 0.00539492362911603 no 65 0.00706330898250412 40 2840123
SGTC_879 0831-1030 162 µM 2.45151582659786 0.00543530823117799 no 66 0.00711279652486912 52 1549252
SGTC_1560 lithocholic acid 53.1 µM 2.44508649433756 0.00553991088995153 no 67 0.00724087033592428 13 9903 A bile acid which acts as a detergent.
SGTC_2539 epi(13)torulosol 80 µM 2.43317661484403 0.00573841374329911 no 68 0.0074834991817127 34 6708597
SGTC_809 3998-0021 90 µM 2.4283059494507 0.00582139554782559 no 69 0.00758477022974294 38 715485
SGTC_2988 9073640 71.4286 µM 2.4263723925655 0.00585463175861602 no 70 0.00762530625270979 34 9102229
SGTC_1003 4049-0218 100 µM 2.41595906574607 0.00603653865479983 no 71 0.007846912773436 42 295161
SGTC_2865 9030313 51.95 µM 2.41025216118522 0.00613834093267459 no 72 0.00797074909523933 15 42562754
SGTC_1199 1638-0010 4.46 µM 2.39993954135991 0.00632616515692986 no 73 0.00819888996567609 28 3111136
SGTC_1205 4161-2785 76 µM 2.39438509251103 0.00642942198727938 no 74 0.00832412953547005 34 3498106
SGTC_881 0833-0569 170 µM 2.39310680411994 0.00645339532434917 no 75 0.00835318856388759 34 5418700
SGTC_3110 9122132 49.47 µM 2.38745854849313 0.00656027343477071 no 76 0.00848265790873788 29 918317
SGTC_264 promethazine 12.5 mM 2.38641404186 0.00658020852880518 no 77 0.00850679209067443 58 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1699 st031318 29.054 µM 2.38579823624993 0.0065919866657229 no 78 0.0085210489997013 30 5340658
SGTC_686 1319-0111 510 µM 2.38456181487318 0.00661569124054751 no 79 0.00854973750091561 37 4562600
SGTC_2135 5326629 150.42 µM 2.37883875074338 0.00672639787155787 no 80 0.00868363563974141 22 5020077
SGTC_277 nystatin 15.5 µM 2.37690939699581 0.00676408644342961 no 81 0.00872918788948354 23 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2677 mitomycin C 100 µM 2.36998149880096 0.00690096041992717 no 82 0.00889448769706086 22 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.3333075762463 0.007667041263727 no 83 0.00981600404842103 20 279621
SGTC_510 ag-490 170 µM 2.33187116915329 0.00769851329560749 no 84 0.00985373480016762 15 5328779
SGTC_2387 9077560 195.08 µM 2.32468957559818 0.00785757524767731 no 85 0.0100442825468547 39 5303272
SGTC_66 0109-0187 42.4 µM 2.31595352443969 0.00805495805897769 no 86 0.0102804031992847 32 759417
SGTC_3099 9120367 49.47 µM 2.29758882994732 0.00848415333046106 no 87 0.0107926009998567 28 24824940
SGTC_768 0384-0033 77.3 µM 2.28929858257442 0.00868438949150254 no 88 0.0110310050052861 56 3965305 YMR134W ERG29
SGTC_3187 9109394 49.47 µM 2.28359870063482 0.00882445299316558 no 89 0.0111975631116818 45 17098090
SGTC_1674 st016616 23.6 µM 2.26130509480902 0.00939146742641607 no 90 0.0118701854847863 38 625830
SGTC_2403 6032726 181.2 µM 2.2567803611861 0.00951036315056602 no 91 0.0120109012392914 34 2881040
SGTC_2023 5144124 124 µM 2.23951472652985 0.00997622513977629 no 92 0.0125612221055502 30 2830192
SGTC_980 1473-0395 201 µM 2.22228488368944 0.0104608570015703 no 93 0.0131320295318339 39 768876
SGTC_2275 7947463 200 µM 2.21863579876714 0.0105660900537109 no 94 0.0132557560081429 49 1225414
SGTC_1518 st038567 90.8 µM 2.20735464273579 0.0108972723838928 no 95 0.0136446462753148 27 77966
SGTC_1636 st007707 68.9 µM 2.20385823460128 0.0110017341313015 no 96 0.0137671577905452 33 403051
SGTC_253 dyclonine 31.25 µM 2.19720891834481 0.0112028004584227 no 97 0.01400276447995 44 3180 An oral anasthetic.
SGTC_3066 9117245 49.47 µM 2.18182549898213 0.0116802586235508 no 98 0.014561206956197 21 17176980
SGTC_902 1120-0002 2.07 µM 2.17514592576167 0.0118930132087194 no 99 0.0148095914207763 48 3280475
SGTC_1203 3992-3522 103 µM 2.1693361219367 0.0120807898712866 no 100 0.0150285873733089 54 5322312
SGTC_2905 7799065 20.05 µM 2.1670011778223 0.0121569778032141 no 101 0.0151173821561344 48 1296806
SGTC_1623 st003709 20.3 µM 2.15943722696177 0.0124066520419956 no 102 0.0154081312028776 36 16192618
SGTC_2912 7964298 10.93 µM 2.15578525569858 0.0125287794504449 no 103 0.0155502186562127 75 2975850
SGTC_2267 7931562 200 µM 2.1535910770515 0.012602655505007 no 104 0.0156361273226007 39 934880
SGTC_144 4161-2749 112.381 µM 2.15192774955782 0.0126589092450692 no 105 0.0157015226447561 63 797501 YMR168C CEP3
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.14951406010929 0.0127409266420254 no 106 0.0157968363764132 56 1273210
SGTC_223 busulfan 5 mM 2.14400131823138 0.0129299761505179 no 107 0.0160163905804055 37 2478 A DNA alkylator.
SGTC_2939 9044578 71.43 µM 2.1298605309883 0.0134260367218049 no 108 0.0165915647541279 42 2653634
SGTC_992 3909-8734 162 µM 2.12770361101902 0.0135031281682475 no 109 0.0166808326702524 44 4288319
SGTC_1511 0906-3109 28.5 µM 2.12483394256988 0.0136062864606308 no 110 0.0168002357505173 58 2882180
SGTC_2727 riluzole 51.77 µM 2.12215141937915 0.0137033316039414 no 111 0.0169125123040295 41 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_585 0kpi-0023 191 µM 2.11572276036448 0.0139383334856667 no 112 0.0171841968199026 32 64601
SGTC_2884 9058502 51.95 µM 2.10667998819715 0.014274771741622 no 113 0.0175726639995255 40 6471554
SGTC_1381 2324-0066 62.1 µM 2.10611660088889 0.0142959622100162 no 114 0.0175971125750329 49 10885928
SGTC_2709 st078560 56 µM 2.10412354678084 0.0143711437722528 no 115 0.0176838356712798 50 17250903
SGTC_1897 st060201 15 µM 2.0922306471362 0.0148268789399971 no 116 0.0182089441068842 40 611878
SGTC_925 2064-1272 59.6 µM 2.09079807633315 0.0148826047937671 no 117 0.0182730843167498 52 6815817
SGTC_836 0330-0104 1.35 µM 2.08098029722473 0.0152693761544812 no 118 0.0187178547597655 41 46494820
SGTC_1690 st023502 41.2 µM 2.07681401473576 0.0154360978267085 no 119 0.0189093641043917 42 24207482
SGTC_344 k064-0035 6.43 µM 2.0686735784716 0.0157663662207424 no 120 0.0192883641015535 44 5088750
SGTC_1727 st034309 9.9045 µM 2.05702967154658 0.0162492997440286 no 121 0.0198416859046908 67 870305
SGTC_2337 9009472 200 µM 2.05666012709025 0.0162648318867579 no 122 0.0198594650660837 58 5742383
SGTC_2974 9094440 9.66 µM 2.05198529077151 0.0164624182121718 no 123 0.0200855459733504 75 25236134
SGTC_203 k066-0004 30.888 µM 2.04934410249938 0.0165749563090956 no 124 0.0202142394912513 55 6795412
SGTC_141 0443-0274 32.331 µM 2.04795030942829 0.0166346092379638 no 125 0.0202824342817358 38 1627241
SGTC_3115 9123671 49.47 µM 2.04750666634211 0.0166536352146867 no 126 0.0203041815008413 31 3286988
SGTC_2377 9073351 62.6 µM 2.04590387311762 0.0167225274723285 no 127 0.0203829146069452 54 7337946 YHR072W ERG7
SGTC_55 0767-0285 6.563 µM 2.04366587123677 0.0168191304665043 no 128 0.0204932834939182 50 3116166
SGTC_2720 fluspirilene 36.88 µM 2.04084947980711 0.0169413774786656 no 129 0.0206328953363316 37 3396 An atypical antipsychotic.
SGTC_1047 2043-3044 82 µM 2.02864939296348 0.0174797398743887 no 130 0.0212470069273272 64 669592
SGTC_2029 5175081 200 µM 2.02405333471206 0.0176863077775138 no 131 0.0214823321747973 52 1380876
SGTC_2885 9057732 51.95 µM 2.00269379181567 0.0186738504599101 no 132 0.0226050827832309 49 6471414
SGTC_2621 lithochol-11-enic acid 100 µM 2.00107208909912 0.0187507092000119 no 133 0.0226923108441397 52 6708711
SGTC_1581 himbacine 57.9 µM 1.98892553483091 0.0193349851776418 no 134 0.0233547114153768 48 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1910 st062352 60.4 µM 1.98743745949491 0.0194076175064872 no 135 0.0234369699994272 38 2245730
SGTC_1072 oxiconazole 14.9 nM 1.98499098791666 0.0195275325567893 no 136 0.0235727370866156 74 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1427 4048-4900 550 nM 1.97608351883822 0.0199694672281432 no 137 0.0240726593677189 51 24132586
SGTC_1035 k081-0041 55.2 µM 1.97383625747985 0.0200822937684164 no 138 0.0242001823213644 52 731709
SGTC_1735 st034310 56.75 µM 1.97025878735931 0.0202630203875981 no 139 0.0244043595636536 65 871153
SGTC_3005 9076496 71.4286 µM 1.96176678713004 0.0206975475053981 no 140 0.0248948210643444 35 21368410
SGTC_2922 7999257 32.47 µM 1.94863849906687 0.0213848266814994 no 141 0.0256693055478809 52 2988377
SGTC_3349 9149703 23.001 µM 1.94859822829977 0.0213869642260048 no 142 0.0256717119446856 32 4910494
SGTC_3290 9121031 71.43 µM 1.94840454350944 0.0213972474048107 no 143 0.0256832883000968 44 17014854
SGTC_633 0437-0093 97.7 µM 1.94658573444618 0.0214940163315523 no 144 0.0257922101224303 53 2831118
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.94152151397818 0.0217654068093579 no 145 0.0260975262394453 38 641818 YHR062C RPP1
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.93630678611343 0.0220478821138726 no 146 0.0264150690785704 57 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2592 piperlongumine 83.33 µM 1.91825716957969 0.0230496130415774 no 147 0.0275392051920532 57 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1810 st050138 53 µM 1.91752584578319 0.0230909956473763 no 148 0.0275855803497135 63 3444541
SGTC_3285 9112818 20.8695 µM 1.91184476620905 0.0234146000993435 no 149 0.0279480539703593 76 17017947 YPR165W RHO1
SGTC_2141 5621638 7.665 µM 1.90710484836594 0.0236875064956476 no 150 0.0282535057745905 48 2856238
SGTC_3031 9088762 49.47 µM 1.90190513533828 0.0239899577221905 no 151 0.0285917788587032 53 205253
SGTC_1215 3852-0577 11.2 µM 1.89784086674358 0.0242286173246593 no 152 0.0288585239881302 50 2884876
SGTC_2198 6589944 200 µM 1.89677165026058 0.0242917334962413 no 153 0.0289290412459544 53 5290268
SGTC_2081 5214970 32.255 µM 1.89599833154263 0.0243374687258849 no 154 0.0289801325747153 42 2063512
SGTC_554 4483-2211 187 µM 1.89585935473009 0.0243456956826404 no 155 0.0289893223867483 37 747107
SGTC_1154 4088-0362 150 µM 1.89337929948533 0.0244928996242771 no 156 0.0291537231373225 60 6618304
SGTC_1392 3455-1037 33.9 µM 1.89316552685362 0.0245056230201262 no 157 0.0291679301293259 59 981132
SGTC_2715 st079500 56.4 µM 1.89217215380902 0.0245648197577006 no 158 0.0292340236137964 55 28246688
SGTC_2238 6671620 73.2395 µM 1.88711541556322 0.0248680224960187 no 159 0.0295724018555507 46 729941
SGTC_346 4513-0042 7.16 µM 1.88582464325401 0.0249459182505864 no 160 0.0296592944722975 66 2827372
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.87822282789636 0.0254088354314617 no 161 0.0301753442748682 53 229346 A bile salt which induces apoptosis.
SGTC_973 1325-0077 65.9 µM 1.8762462814317 0.0255303702456662 no 162 0.0303107348136612 46 2835149
SGTC_2354 9060492 162 µM 1.87547097444782 0.0255781754224436 no 163 0.0303639794883114 51 6471895
SGTC_430 0958-0115 16.4 µM 1.8752777667775 0.0255901002036555 no 164 0.0303772601979356 65 6833180
SGTC_1519 esterone 74 µM 1.87481636051656 0.0256185970396744 no 165 0.0304089958163301 60 698 A steroid.
SGTC_2759 disulfiram 3.38 µM 1.87030894465118 0.0258983788220386 no 166 0.0307204640748187 85 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_457 grayanotoxin iii 135 µM 1.8590657259229 0.0266074204623071 no 167 0.0315089113449513 80 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_108 0509-0257 621.132 µM 1.85406860876085 0.0269277245836166 no 168 0.0318646725191619 74 536624
SGTC_1600 coumarin 106 71.1 µM 1.8407118719717 0.0277996944755293 no 169 0.0328318966200073 54 100336 A hepatotoxic, DNA x-linker.
SGTC_420 mitomycin C 81.9 mM 1.83679439607165 0.02805985749058 no 170 0.0331201267627364 78 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_499 genistein 192 µM 1.82397642252708 0.0289253182821872 no 171 0.0340778183874763 43 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2257 7960413 200 µM 1.82147021274646 0.0290971029626041 no 172 0.0342677053140179 72 2974689 YIL048W NEO1
SGTC_3012 9080433 71.4286 µM 1.81691406592771 0.0294115688388935 no 173 0.0346151362826407 69 17688859
SGTC_3106 9121286 49.47 µM 1.80988384186997 0.029902328448877 no 174 0.0351569011874326 55 15943471
SGTC_1411 3909-8223 150 µM 1.80670238779677 0.0301266385187453 no 175 0.0354043476031736 82 X1411
SGTC_556 4058-0063 51.5 µM 1.80112823808212 0.0305230094101676 no 176 0.0358413349430083 58 6615692
SGTC_1998 st075797 76.8 µM 1.79632449421279 0.0308680541122381 no 177 0.0362214622487234 60 24208315
SGTC_626 0214-0009 33 µM 1.79485224304001 0.0309744475298941 no 178 0.0363386222802804 66 3437874
SGTC_748 act1.228 77.9 µM 1.78694669594688 0.031550950335711 no 179 0.0369730521265136 60 4421505 YNR035C ARC35
SGTC_1530 rhein 70.4 µM 1.78514180312553 0.0316838061495849 no 180 0.0371191594178004 61 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1762 st045503 25.4615 µM 1.77776506785388 0.0322316123127666 no 181 0.0377212239694475 51 4645554
SGTC_797 k781-0471 270 µM 1.77640940647917 0.0323331310131853 no 182 0.0378327309083692 72 23738129
SGTC_3163 9099914 49.47 µM 1.77354779563175 0.0325482891764014 no 183 0.0380689896723931 53 16268368
SGTC_2587 piperic acid 92.2 µM 1.76377872349542 0.0332917187330779 no 184 0.0388846205006632 56 5370536
SGTC_820 1582-0060 59.9 µM 1.75237323308574 0.0341773170915746 no 185 0.0398548254722068 73 3848840
SGTC_2931 9014674 55.67 µM 1.75012202118129 0.0343543848209744 no 186 0.0400486303274242 57 2996810
SGTC_649 1123-0311 367 µM 1.74736639851693 0.0345721521366645 no 187 0.0402869010866261 75 693629 YIL048W NEO1
SGTC_1819 st053448 58.6 µM 1.74711942803042 0.0345917246018442 no 188 0.0403083120139582 78 2857616
SGTC_282 k297-0036 65.7 µM 1.73722432016833 0.0353834325583693 no 189 0.0411737918776345 68 5061378
SGTC_2352 9027995 87.8 µM 1.73204674066188 0.0358035765256053 no 190 0.0416326203530672 61 2997347
SGTC_607 4491-0986 66.8 µM 1.72870324709308 0.0360770561417059 no 191 0.0419311099568269 54 698981 YDR232W HEM1
SGTC_10 0279-0212 42.575 µM 1.72678187863693 0.0362349861110886 no 192 0.0421034220864096 64 39851 YBR002C RER2
SGTC_939 1165-0479 45.3 µM 1.72479296757833 0.0363990635890605 no 193 0.0422823947790647 69 1377347
SGTC_2540 epiandrosterone 100 µM 1.71729427388905 0.0370231531653815 no 194 0.0429627088774737 77 441302 A steroid.
SGTC_1839 st053978 48 µM 1.71673470143304 0.0370700729668498 no 195 0.043013828331896 55 3788398
SGTC_2816 7982706 58.44 µM 1.71325383297076 0.0373630341678728 no 196 0.043332925889202 90 2981853
SGTC_1702 st027038 51 µM 1.7116174404276 0.0375014103480339 no 197 0.0434835960687805 65 5521182
SGTC_1419 3993-2473 62.6 µM 1.7084709630324 0.0377686578689917 no 198 0.0437744948842288 65 704026
SGTC_2683 piperine 63.03 µM 1.70672036407928 0.0379180175337246 no 199 0.043937020155245 71 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1633 st005664 67.9 µM 1.70605980897278 0.0379745006408666 no 200 0.0439984722847596 70 2063822
SGTC_1854 st056233 32.9 µM 1.70268326322418 0.0382642973471193 no 201 0.0443136793280532 76 5393174
SGTC_3281 9140613 49.47 µM 1.69934110470422 0.0385529160234186 no 202 0.0446274659678104 62 16013766
SGTC_2769 toremifene 3.73 µM 1.69652884222339 0.0387971467379972 no 203 0.0448928863964444 78 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2702 st077768 96.8 µM 1.69652881787195 0.0387971488582391 no 204 0.0448928887002149 58 6484119
SGTC_1014 4130-3005 69.3 µM 1.69247841487977 0.0391511189932579 no 205 0.0452773961455469 70 743608
SGTC_2607 solasodine 47.35 µM 1.69204491375961 0.0391891584683827 no 206 0.0453187051743579 101 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3174 9107204 49.47 µM 1.69144797107096 0.0392415890743957 no 207 0.0453756384279223 54 3938802
SGTC_1024 4507-0395 26 µM 1.68591753259021 0.0397300572107051 no 208 0.045905842243876 75 4201836
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.66942796342294 0.0412158825016312 no 209 0.0475162978258928 77 803109
SGTC_204 PMA1.184 62.41 µM 1.66721035165934 0.0414190978349159 no 210 0.0477362925445881 85 2252213 YGL008C PMA1
SGTC_1982 st072467 71.9 µM 1.66538404672028 0.0415870640224249 no 211 0.0479180800734513 92 3163533
SGTC_1657 st012939 43.4 µM 1.66434357065777 0.0416830036119888 no 212 0.0480218949661924 48 24207257
SGTC_226 1,3-diallylurea 8.28947 mM 1.66362747580275 0.0417491369456582 no 213 0.0480934488103257 86 74537 YKL182W FAS1
SGTC_2080 5212524 12.4 µM 1.66170243870953 0.041927340776866 no 214 0.0482862259634832 76 260183
SGTC_2665 lovastatin 100 µM 1.6606549835047 0.0420245638260979 no 215 0.0483913796624058 66 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1468 k284-1086 134 µM 1.6595889969415 0.0421236942039422 no 216 0.048498581676698 89 15996457
SGTC_849 0386-0493 241 µM 1.65785282827209 0.0422855525469289 no 217 0.0486735876670808 80 726119
SGTC_2038 4100038 30.985 µM 1.65587777656185 0.0424702927140814 no 218 0.0488732864797163 93 3596803
SGTC_407 eburnamonine 100 µM 1.65335057254586 0.0427076308982389 no 219 0.0491297680303097 71 3195
SGTC_2626 ethyl orsellinate 100 µM 1.65217060887448 0.0428188118257836 no 220 0.0492498880866521 105 75653 A natural product.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.64869223394027 0.0431479200887913 no 221 0.0496053509882604 80 5377381
SGTC_729 4092-0585 94.1 µM 1.64721354860433 0.0432884441812161 no 222 0.0497570799742701 73 2169061
SGTC_1094 duloxetine 25.4 µM 1.64471093748554 0.0435271169743352 no 223 0.0500147180965195 66 60834 A selective serotonin reuptake inhibitor.
SGTC_2658 polymyxin b sulfate 77.05 µM 1.6406315524418 0.0439184416616873 no 224 0.0504369605850496 87 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1368 1852-0141 284 µM 1.63538665542699 0.0444257348865321 no 225 0.0509840090333123 80 2838987
SGTC_1676 st018489 23.4 µM 1.61904589667626 0.0460365653341572 no 226 0.0527186941690231 70 3696235
SGTC_2218 6965428 192.983 µM 1.61762865097583 0.0461784570226629 no 227 0.0528713253540312 62 675684
SGTC_300 r073-0011 5.04 µM 1.6168389111352 0.046257676389711 no 228 0.0529565288557555 79 2735780
SGTC_2315 7733312 200 µM 1.61634429085843 0.046307347654476 no 229 0.0530099479168489 89 726316
SGTC_526 4469-0568 170 µM 1.61506432922653 0.0464360840899285 no 230 0.0531483823420663 83 2901964
SGTC_2810 7959871 45.46 µM 1.60916240922604 0.047033410307921 no 231 0.0537904168356251 95 2974535
SGTC_1389 3405-0187 19 µM 1.60769066315811 0.0471833196642554 no 232 0.0539514722388298 70 799890
SGTC_2929 9013348 24.6 µM 1.60521524264959 0.0474363251015407 no 233 0.0542232220655713 77 2995952
SGTC_3035 9091303 49.47 µM 1.60226446236316 0.0477393345292579 no 234 0.0545485703321559 75 25237002
SGTC_2797 7859098 81.82 µM 1.60076952950181 0.0478934364929413 no 235 0.0547139873794574 89 972681
SGTC_1785 bathophenanthroline 24 µM 1.60047511515971 0.0479238324518103 no 236 0.0547466115573002 115 72812 An iron chelator.
SGTC_2452 5863136 48.41 µM 1.5952467811421 0.0484661931214052 no 237 0.0553285306335562 80 2184096
SGTC_933 2914-0560 114 µM 1.59436442007891 0.0485582069809786 no 238 0.0554272183421729 84 463887
SGTC_38 0929-0051 58.268 µM 1.58837881516377 0.0491860872412085 no 239 0.0561003524823479 87 1379719
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.58750584979345 0.0492781992620023 no 240 0.0561990615661889 68 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_700 3453-2283 142 µM 1.58571379507961 0.0494677217159112 no 241 0.0564021241915642 87 565664
SGTC_1086 cerivastatin 2.18 µM 1.58509714570847 0.0495330711307013 no 242 0.0564721320024716 74 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1963 st076565 50.3 µM 1.58167769121587 0.0498966991005722 no 243 0.0568615840149443 102 4914280
SGTC_2869 9037858 32.47 µM 1.57885148940853 0.0501988443495099 no 244 0.0571850625789577 74 27187042
SGTC_3211 9128781 49.47 µM 1.57780546170038 0.0503110427997856 no 245 0.0573051543585408 88 17194361
SGTC_1766 st045414 44.774 µM 1.57626679740706 0.0504764452727652 no 246 0.0574821650463005 99 253960
SGTC_1744 st037937 38.9 µM 1.5757495106322 0.0505321494859914 no 247 0.0575417711537933 82 1016152
SGTC_1933 st074711 15.9 µM 1.56881851959983 0.0512832494520463 no 248 0.0583451159358895 115 17250958
SGTC_2124 5246320 200 µM 1.56803642510337 0.0513685584860972 no 249 0.0584363159187093 115 579342
SGTC_1227 3909-8010 46.6 µM 1.56591671340438 0.0516003392965296 no 250 0.0586840582755274 68 15982272
SGTC_601 0986-0029 62.9 µM 1.55476536255138 0.052833412957789 no 251 0.0600009806319423 89 24747981
SGTC_1629 st005085 44.9 µM 1.55383703880802 0.0529371085413833 no 252 0.0601116465526626 105 24207091
SGTC_429 1112-0049 25.5 µM 1.54540617814496 0.0538862583021422 no 253 0.0611240234344158 87 2836170
SGTC_2066 5222451 176 µM 1.53582641750874 0.0549810511800874 no 254 0.0622904793691031 127 2281147
SGTC_1204 4049-0315 18.3 µM 1.53376969842323 0.0552183732213098 no 255 0.0625431600299923 83 588402
SGTC_2368 9071271 200 µM 1.53086175315698 0.0555552969850674 no 256 0.06290178178172 70 27209959
SGTC_1887 st057648 70.8 µM 1.52931226039647 0.0557354877173316 no 257 0.0630935258263708 115 688672
SGTC_927 2425-1185 123 µM 1.52876852189666 0.0557988283492649 no 258 0.0631609192645508 110 730375
SGTC_2780 5215298 71.43 µM 1.52425751231389 0.0563265128935672 no 259 0.0637221981256939 119 2834131
SGTC_590 k048-0076 22.4 µM 1.52374526487433 0.0563866819691845 no 260 0.0637861786771522 99 6832814
SGTC_776 4476-4378 112 µM 1.52314660508331 0.0564570653103279 no 261 0.0638610155864664 82 2892008
SGTC_710 3448-4187 58 µM 1.52280067011316 0.0564977678078338 no 262 0.063904291141765 99 3946412
SGTC_1314 1222-0010 41.1 µM 1.52195364444548 0.0565975259608594 no 263 0.0640103481115028 82 3526027
SGTC_2251 lansoprazole 556 µM 1.50606893375843 0.0584941654165295 no 264 0.0660247393104133 75 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1740 st038286 13.222 µM 1.50078134703108 0.0591364600815328 no 265 0.0667060623703167 96 716786
SGTC_2614 arthonioic acid 13.39 µM 1.50067489411712 0.0591494477246713 no 266 0.0667198348418901 75 6710684
SGTC_1776 st049249 45.9 µM 1.50028397417216 0.0591971605739518 no 267 0.0667704294495837 112 1822314
SGTC_1782 st039423 80.636 µM 1.49881612014596 0.0593765856655485 no 268 0.0669606707319997 84 2068169
SGTC_1838 st055369 84.5 µM 1.4985460462136 0.059409644904134 no 269 0.0669957192987513 86 676036
SGTC_796 1234-0020 70.7 µM 1.4936000044161 0.0600176358716587 no 270 0.0676400991473293 89 46495034
SGTC_2928 9011484 9.79 µM 1.49266707925005 0.0601328597671634 no 271 0.067762177443925 128 2994751
SGTC_2880 9042983 58.44 µM 1.4903745708592 0.0604167390303632 no 272 0.0680628874644518 115 6464714
SGTC_2832 7992762 51.95 µM 1.48672334894297 0.0608710304888226 no 273 0.0685439466460681 92 2985177
SGTC_3325 9138760 55.175 µM 1.48094086713208 0.0615959562301415 no 274 0.069311165829116 85 43844959
SGTC_669 0108-0021 26.2 µM 1.47885720416949 0.061858822558289 no 275 0.0695892416372979 90 17201
SGTC_1931 st074438 57.1 µM 1.47760745199865 0.0620169057184441 no 276 0.0697564392936193 136 2787313
SGTC_3043 9092303 49.47 µM 1.47679052075913 0.0621204109238754 no 277 0.0698658991645054 89 25236084
SGTC_2321 7390090 138.78 µM 1.47595174033807 0.0622268245970497 no 278 0.069978424072435 84 649046
SGTC_3087 9117406 49.47 µM 1.47553816427103 0.0622793461215943 no 279 0.0700339578449572 97 42546093
SGTC_1001 4048-4355 44.4 µM 1.47078430547813 0.0628855414990049 no 280 0.0706747290773063 119 21824233
SGTC_3022 9087993 49.47 µM 1.47031470494122 0.062945671934418 no 281 0.0707382701153577 91 17173644
SGTC_1868 st057644 42.7 µM 1.46851224531188 0.0631768855211548 no 282 0.0709825662400275 98 688665
SGTC_935 2996-0153 430 µM 1.46785157994158 0.0632617989375812 no 283 0.0710722715431122 106 23738523
SGTC_1431 4049-0260 9.09 µM 1.4646257027792 0.0636776884362406 no 284 0.0715115327626551 112 3854841
SGTC_338 4055-0136 114 µM 1.46017136343079 0.0642554475312872 no 285 0.0721214917419101 85 2900563
SGTC_1457 k015-0032 57.3 µM 1.45899494933517 0.0644087147751867 no 286 0.0722832489063002 98 4302660
SGTC_2219 9098279 200 µM 1.45856428073486 0.0644648947271499 no 287 0.0723425353917366 50 902349
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.45325804884505 0.0651602113812241 no 288 0.0730760601550868 97 688761
SGTC_303 1348-1668 34.2 µM 1.44748999588937 0.0659226303472168 no 289 0.0738798681707237 104 5380509
SGTC_1328 1441-0025 69.2 µM 1.44714347610326 0.0659686523987981 no 290 0.0739283717951156 86 4562601
SGTC_3072 9116419 49.47 µM 1.44598870539705 0.0661221997600615 no 291 0.0740901848813674 109 17170162
SGTC_2301 7769476 200 µM 1.43843671465856 0.0671332064929931 no 292 0.0751550908311405 110 977820
SGTC_653 0203-0016 55.2 µM 1.43792735027311 0.0672018245294423 no 293 0.0752273342579527 108 295302
SGTC_311 1315-0136 58 µM 1.43483822202775 0.0676191327411774 no 294 0.0756666016601266 88 6759207
SGTC_1947 st076332 61.6 µM 1.43456742228032 0.0676558101317128 no 295 0.0757052017646538 105 24208416
SGTC_2262 9014885 67.46 µM 1.42711097212009 0.0686717688550157 no 296 0.0767739551832794 74 6457424
SGTC_2112 5488546 200 µM 1.42376638009448 0.0691312821510044 no 297 0.0772570554568117 108 600757
SGTC_95 0471-0001 561.058 µM 1.41514680189952 0.0703264462542414 no 298 0.0785127291699947 110 4015405
SGTC_1267 0828-0272 9.49 µM 1.41351242283641 0.0705548456199056 no 299 0.0787525556555959 109 745334
SGTC_1985 st071382 65.5 µM 1.41200383687167 0.070766171423079 no 300 0.0789744157190615 128 6123237
SGTC_3126 9127922 49.47 µM 1.41086252125856 0.0709263721443703 no 301 0.0791425775228581 157 45595682
SGTC_1423 4048-0112 5.59 µM 1.40701857470623 0.0714679771285137 no 302 0.0797109404695065 108 X1423
SGTC_1160 4092-0570 10.5 µM 1.40566499065317 0.0716594483769652 no 303 0.0799118137259538 115 4994975
SGTC_929 2805-0021 398 µM 1.40455623961249 0.0718165797676503 no 304 0.0800766385221581 119 3098024
SGTC_1879 gemcitabine 100 µM 1.40453497722737 0.0718195956377007 no 305 0.0800798018571184 105 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3223 9129970 49.47 µM 1.40436589436603 0.0718435819144319 no 306 0.0801049607103858 116 17248386
SGTC_315 k915-0449 187 µM 1.39936220681088 0.0725561949056701 no 307 0.0808521970321047 98 20970215 YNL149C PGA2
SGTC_1128 3448-9350 235 µM 1.39929077035606 0.0725664077693083 no 308 0.080862903119198 89 619386
SGTC_2479 5617353 43.85 µM 1.39853735784645 0.0726741859243802 no 309 0.0809758812321643 132 2731746
SGTC_2783 7738165 71.43 µM 1.39473809246917 0.0732195520168042 no 310 0.0815474167193418 102 17201110
SGTC_830 4076-0286 57.8 µM 1.39156547703074 0.0736773599897248 no 311 0.082027009562181 116 6866659
SGTC_954 1189-0853 2.85 µM 1.39140539123354 0.0737005182112331 no 312 0.0820512653561425 110 2828194
SGTC_1966 st070145 16.1 µM 1.39132307157877 0.0737124288466599 no 313 0.0820637403250913 124 3748532
SGTC_1747 st037496 66.6 µM 1.39088648805504 0.0737756216766585 no 314 0.0821299253962118 138 723305
SGTC_3159 9100096 49.47 µM 1.38981843356044 0.0739303906696629 no 315 0.0822920095343515 97 25236875
SGTC_609 0986-0026 86.3 µM 1.38800297989662 0.0741940324177728 no 316 0.082568068858926 111 2848610
SGTC_2824 7998404 51.95 µM 1.38655959506638 0.0744041539366186 no 317 0.0827880480756822 117 837851
SGTC_1036 k216-0215 33.5 µM 1.38446319799341 0.0747101468186462 no 318 0.0831083346663908 94 622330
SGTC_1602 st001878 87.6 µM 1.38010267917673 0.0753496887034955 no 319 0.0837775162515699 132 595405 YLR310C CDC25
SGTC_1774 st048371 48.465 µM 1.37753178573184 0.0757287031585555 no 320 0.084173947248745 148 4242727
SGTC_1438 4092-1045 4 µM 1.37714479811994 0.0757858804123139 no 321 0.0842337423518135 129 1351342
SGTC_883 0850-0245 24.6 µM 1.37106565584709 0.0766883918216895 no 322 0.0851772449687663 128 6823229 YPR165W RHO1
SGTC_1574 spiramycin 23.7 µM 1.36639011373248 0.0773880670091982 no 323 0.0859082750768262 123 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3156 9099931 49.47 µM 1.36629510293701 0.0774023350719577 no 324 0.0859231787235138 108 18111053
SGTC_1463 k081-0032 34.1 µM 1.36204666543808 0.0780423801105793 no 325 0.0865915792341291 101 977755
SGTC_1342 1486-1464 234 µM 1.36101130000488 0.0781989691094347 no 326 0.0867550592308233 116 3253938
SGTC_2385 9074692 200 µM 1.35949980490557 0.0784279958348684 no 327 0.0869941321330579 99 17046906
SGTC_2930 9013230 14.89 µM 1.35816849812199 0.0786301407421928 no 328 0.0872051119947113 126 2995857
SGTC_627 1391-0720 175 µM 1.35689928114499 0.0788232254165143 no 329 0.0874066076518279 138 997839
SGTC_365 0121-0052 13.6 µM 1.35643429640907 0.0788940529054445 no 330 0.0874805136259688 105 3101739
SGTC_3051 9093778 49.47 µM 1.35366766943015 0.0793164687349668 no 331 0.0879212135988701 141 17217378
SGTC_1547 harmine 94.2 µM 1.35300392538463 0.079418065095753 no 332 0.0880271881724379 139 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2906 7926292 26.41 µM 1.35026615773687 0.0798381642463515 no 333 0.0884653118425943 101 2966319
SGTC_1575 cyproterone acetate 48 µM 1.34706864633533 0.0803309343868028 no 334 0.0889790624942322 128 9880 An androgen receptor antagonist and liver toxin.
SGTC_1137 ixabepilone 100 µM 1.33846985046326 0.0816674974859319 no 335 0.0903716610857388 119 154225 A novel microtubule stabilizer.
SGTC_2564 betulinic acid 100 µM 1.33772396261333 0.0817842209242352 no 336 0.0904932183026685 110 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_509 pifithrin 175 µM 1.335699374401 0.082101681087701 no 337 0.0908237769737552 114 4817 A p53 inhibitor.
SGTC_2784 7567673 72.73 µM 1.32705914186912 0.0834669302801384 no 338 0.0922445597935838 125 3471247
SGTC_1058 3448-5425 97.3 µM 1.32583824042877 0.0836612136193601 no 339 0.0924466417215686 136 7279705
SGTC_2399 5884133 200 µM 1.32542913664057 0.0837263906783505 no 340 0.0925144292355694 127 722445
SGTC_2725 haloperidol 53.21 µM 1.32140321651448 0.0843698228609275 no 341 0.0931834770656971 140 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2225 6654152 15.4 µM 1.3206923888629 0.0844838134080014 no 342 0.0933019764579105 136 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1635 st007035 42.4 µM 1.32043038972282 0.0845258575394462 no 343 0.093345681413641 128 3716403
SGTC_2951 9072950 58.06 µM 1.3195344530973 0.0846697509665252 no 344 0.0934952498976916 124 16488155
SGTC_2165 5727197 32.143 µM 1.31656237531041 0.08514840218222 no 345 0.0939926787350041 123 1361712
SGTC_1891 st059073 26.2 µM 1.31288716667305 0.0857430926368613 no 346 0.0946104859427259 137 688754
SGTC_625 k213-0058 121 µM 1.31121761245397 0.0860142702316372 no 347 0.0948921268128679 154 3655420
SGTC_1939 st074455 53.6 µM 1.31031738286791 0.086160756197407 no 348 0.0950442446707203 122 1644229
SGTC_1303 1160-0052 261 µM 1.30982792425753 0.0862404795074219 no 349 0.0951270271303433 106 3562476
SGTC_105 0111-0055 734.78 µM 1.30777295155444 0.0865757968433897 no 350 0.0954751655445892 109 5179370
SGTC_1591 genipin 88.4 µM 1.30609654581604 0.0868500630787696 no 351 0.0957598637441132 138 442424 A DNA cross-linking agent.
SGTC_2331 7980721 200 µM 1.30597678436873 0.08686968131487 no 352 0.0957802262936574 137 2981221
SGTC_850 0388-0143 75.9 µM 1.3054385614279 0.0869578890007626 no 353 0.0958717774657916 118 67273
SGTC_870 0573-2213 57.6 µM 1.30142030199116 0.0876185444843075 no 354 0.0965573140780927 112 3916321
SGTC_1651 st011928 86.1 µM 1.29858233315101 0.0880873961418994 no 355 0.0970436520820963 122 720198
SGTC_3234 9132280 49.47 µM 1.29760404294037 0.0882494490658893 no 356 0.0972117160883756 125 17612295
SGTC_953 1188-0045 9.7 µM 1.29723839500022 0.0883100753421256 no 357 0.0972745868690242 126 6144426
SGTC_3181 9108277 49.47 µM 1.29698392733314 0.0883522856810736 no 358 0.0973183585287393 131 17097298
SGTC_210 3551-0445 56.827 µM 1.29613128989343 0.0884938282285867 no 359 0.0974651282867647 113 2865180 YOR207C RET1
SGTC_1317 1273-0028 910 nM 1.29569506310878 0.0885663095894917 no 360 0.0975402814530411 138 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3304 9125678 46.087 µM 1.29521712973988 0.0886457714749848 no 361 0.0976226686090881 142 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1568 digitonin 820 nM 1.29191429852864 0.0891963568978914 no 362 0.098193412719815 149 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3143 9086658 49.47 µM 1.28859903032841 0.089751570574627 no 363 0.0987687603576066 151 25236626
SGTC_3189 9110682 49.47 µM 1.28807643436944 0.0898393245239101 no 364 0.0988596788155726 125 17122418
SGTC_2502 avocadyne acetate 18.59 µM 1.28759416648336 0.0899203631784636 no 365 0.098943635527564 114 3952079
SGTC_1857 st056007 79.3 µM 1.28598477534304 0.0901911929362813 no 366 0.0992241875522694 103 619834
SGTC_551 k048-0028 34.9 µM 1.28378329979679 0.0905626398475794 no 367 0.0996088942502821 144 6836383
SGTC_958 1222-0007 33 µM 1.28358513573131 0.0905961309753305 no 368 0.0996435767137444 140 7312461
SGTC_2115 tiliquinol 12.7705 µM 1.27910996907856 0.0913549158655359 no 369 0.100429166769041 134 71208 A bioactive hydroxyquinoline.
SGTC_726 3448-4391 34.2 µM 1.27752615363983 0.0916245846291413 no 370 0.100708276512357 140 1356692
SGTC_2582 agaric acid 100 µM 1.2774932316451 0.091630196352527 no 371 0.100714084225734 158 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_525 k781-2675 26.7 µM 1.27648672275057 0.0918018839052883 no 372 0.100891758663554 149 3651118 YDL195W SEC31
SGTC_5 0352-0601 109.883 µM 1.27622914595698 0.0918458589243573 no 373 0.10093726422661 110 762456
SGTC_1713 st033146 12.748 µM 1.27225921558327 0.0925256033335729 no 374 0.101640517143909 130 674619
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.27045593212553 0.0928355937692715 no 375 0.101961135320898 99 1241132 A phosphatase inhibitor.
SGTC_2488 5268135 45.7 µM 1.26946353582485 0.0930065172587547 no 376 0.102137893955056 145 1270356 YLR208W SEC13
SGTC_1043 0916-0009 19.3 µM 1.26890740798899 0.0931024025262416 no 377 0.102237044939332 144 3101130
SGTC_564 3555-0129 330 µM 1.26860342507716 0.0931548448779599 no 378 0.102291271064388 122 563260
SGTC_3299 9121982 43.1275 µM 1.26828242330661 0.0932102469734547 no 379 0.102348555810784 122 17594604 YPL160W CDC60
SGTC_717 1532-0246 73.2 µM 1.26695598000939 0.0934394376563695 no 380 0.102585515186884 130 9561992
SGTC_1870 st057514 26.5 µM 1.26582747888629 0.0936347542193475 no 381 0.102787427414072 131 5393161
SGTC_3184 9108758 49.47 µM 1.26427565024623 0.0939038307269374 no 382 0.103065553088782 128 902885
SGTC_663 1486-0733 13.9 µM 1.26217514363918 0.0942689526861102 no 383 0.103442885380884 140 722445 YPR165W RHO1
SGTC_59 0330-0160 1.33 µM 1.25809861917254 0.0949805434117661 no 384 0.104178046328742 124 4293482
SGTC_3079 9117512 49.47 µM 1.25560670401303 0.0954174718610881 no 385 0.104629299773978 163 7185044
SGTC_1373 2887-0003 58.5 µM 1.25513409596735 0.0955005048502803 no 386 0.104715042430184 156 776948
SGTC_377 3970-0964 33.1 µM 1.2544708275002 0.0956171248341031 no 387 0.104835461355123 122 16481235
SGTC_882 0843-0131 351 µM 1.25145407787362 0.0961488708842188 no 388 0.105384428984647 160 5425421
SGTC_2775 cyproheptadine 69.59 µM 1.24897838646194 0.0965868690831891 no 389 0.105836489607068 126 2913 A selective serotonin reuptake inhibitor.
SGTC_766 1391-0721 126 µM 1.24585596517179 0.0971413742391643 no 390 0.106408639450882 150 1020919 YIL115C NUP159
SGTC_844 0330-0132 15.3 µM 1.24352298297837 0.0975572067183154 no 391 0.106837588560986 133 2828079
SGTC_1752 st044819 83.042 µM 1.24099732787696 0.0980088513160218 no 392 0.107303368001498 129 441209 YML126C ERG13
SGTC_990 3985-0011 41.3 µM 1.24001723788544 0.0981845257272529 no 393 0.107484509180994 134 5399565 YGL099W LSG1
SGTC_2788 5282734 71.43 µM 1.23853022114496 0.0984515035997172 no 394 0.107759761728862 147 743706
SGTC_1866 st057638 64 µM 1.23810963345127 0.0985271119446927 no 395 0.107837706175741 92 688802
SGTC_1418 3966-3099 2.4 µM 1.23436302883824 0.0992025095135045 no 396 0.10853382955581 156 740335
SGTC_2335 9018011 154.17 µM 1.23260449317864 0.0995206843195691 no 397 0.108861679878109 138 6458208
SGTC_1958 st076513 41.9 µM 1.23254660042606 0.0995311716184705 no 398 0.108872485131414 149 732122 YGL099W LSG1
SGTC_1686 st019653 115.5 µM 1.22954746803153 0.100075571085686 no 399 0.109433306020495 149 97252
SGTC_1485 3909-9022 254 µM 1.22934288134479 0.100112786510742 no 400 0.109471638038669 134 714516
SGTC_2242 6630449 61.2675 µM 1.22814791567142 0.100330359107568 no 401 0.109695723299624 122 691249 YDR170C SEC7
SGTC_956 1185-0240 191 µM 1.22703889060624 0.100532592692174 no 402 0.109903987048476 131 1416193
SGTC_2420 aureobasidin a 50 nM 1.2260565901439 0.100711965940012 no 403 0.110088690031683 114 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_21 0849-0113 22.993 µM 1.22572574609763 0.100772432324453 no 404 0.110150949087273 127 1560156
SGTC_1650 st011916 45.8 µM 1.22549813431934 0.100814046934904 no 405 0.110193796300388 137 242528
SGTC_431 k089-0097 107 µM 1.22361347891282 0.101159102910127 no 406 0.110549036206794 155 5499420
SGTC_295 k015-0027 31 µM 1.22321422134972 0.101232312143264 no 407 0.11062439777774 111 3887424
SGTC_1515 3460-0031 42.1 µM 1.2226878681866 0.101328885046297 no 408 0.110723805444769 141 2876596
SGTC_1174 0739-0097 51.1 µM 1.22235788008496 0.101389463993901 no 409 0.110786160015579 146 728447
SGTC_674 0498-0004 451 µM 1.22219448800992 0.101419469142135 no 410 0.110817043903245 162 4231473
SGTC_658 3253-0951 102 µM 1.22163378765242 0.101522484746546 no 411 0.110923072732779 152 1184878
SGTC_2505 galangin 7.89 µM 1.22106051440401 0.101627889093327 no 412 0.111031554218318 156 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2750 bromebric acid 70.15 µM 1.21970400026031 0.101877620609611 no 413 0.11128855230395 132 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3321 9137793 26.8275 µM 1.21861332322847 0.102078735752318 no 414 0.111495494908514 160 4904192
SGTC_2878 9043973 25.97 µM 1.21771911903351 0.102243837705922 no 415 0.111665364522607 127 6465167
SGTC_193 1273-0060 1.558 µM 1.20941586756558 0.103786196540105 no 416 0.11325155779234 146 2847393 YHR072W ERG7
SGTC_1159 4092-0538 61.2 µM 1.20767646329914 0.104111424239732 no 417 0.113585867411098 147 717301
SGTC_128 0906-2981 13.371 µM 1.20714703866751 0.104210560714299 no 418 0.113687761172957 158 6740226
SGTC_1706 st031321 9.9705 µM 1.20588252751625 0.104447621374676 no 419 0.11393139427684 140 6103185
SGTC_2314 7727897 200 µM 1.20525728691482 0.104564980852484 no 420 0.114051996607726 115 900724
SGTC_2106 5357045 167.29 µM 1.20312602915387 0.104965741864635 no 421 0.11446377707457 146 668842
SGTC_1282 0886-0010 32.4 µM 1.19966711544924 0.105618519490986 no 422 0.115134324670812 160 2836211 YNL267W PIK1
SGTC_3081 9117243 49.47 µM 1.19601756004477 0.106310452819351 no 423 0.115844853275896 171 45595589
SGTC_395 anisomycin 6.25 µM 1.19317869803264 0.106850942956245 no 424 0.116399697732529 144 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_960 1222-0186 7.7 µM 1.19040111581904 0.107381682220918 no 425 0.116944387354644 148 3126296
SGTC_460 trequinsin 123 µM 1.19016538368308 0.107426813148301 no 426 0.116990697937377 150 5537 A vasodilator.
SGTC_666 0272-0154 136 µM 1.1894377584507 0.107566203254033 no 427 0.117133724978575 161 6870312
SGTC_92 0063-0024 660.874 µM 1.18795110468428 0.107851404425367 no 428 0.117426336937217 127 3594437
SGTC_2473 5854593 8.94 µM 1.18718149056252 0.107999261753309 no 429 0.117578020096964 151 2872951
SGTC_950 1165-0508 94.1 µM 1.18695569264057 0.108042669455341 no 430 0.117622548889165 138 6148369
SGTC_654 1124-0271 80.9 µM 1.18630934641344 0.108166993379384 no 431 0.117750078479818 152 5403748
SGTC_1610 st001799 48.1 µM 1.18297923774535 0.108809168008458 no 432 0.118408687996239 127 621897
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.18034696816833 0.109318708467759 no 433 0.11893112240728 147 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2937 9044753 11.33 µM 1.176583367971 0.110050219869662 no 434 0.119680919703008 128 6465530 YGL099W LSG1
SGTC_1604 st002052 72.4 µM 1.17604524069798 0.110155099163532 no 435 0.119788399070546 129 6254834 YHR062C RPP1
SGTC_2765 myclobutanil 7.74 µM 1.17373804141382 0.110605577624536 no 436 0.120249983971249 163 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_682 0kpi-0099 17 µM 1.17351223298211 0.110649737341865 no 437 0.120295227085115 188 1714895 YML126C ERG13
SGTC_1009 4106-0057 9.87 µM 1.1712941270381 0.111084188029035 no 438 0.120740285644509 171 2928005
SGTC_1588 farnesol 29.9 µM 1.16961063152744 0.111414741379172 no 439 0.121078848477285 153 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_592 k241-0073 46.5 µM 1.16509633458607 0.112304594268721 no 440 0.1219900002059 155 4230158
SGTC_2903 5923464 63.88 µM 1.1635901283397 0.112602622791849 no 441 0.122295076920681 148 2876576
SGTC_1350 1495-0454 146 µM 1.16135458173871 0.113046004394622 no 442 0.122748865585282 146 1069057
SGTC_1298 1079-1278 263 µM 1.16037442188233 0.113240794355041 no 443 0.122948198020971 146 2840950
SGTC_2443 5493264 126.67 µM 1.15948434956446 0.113417888306484 no 444 0.123129406122627 146 5340055
SGTC_1290 0986-0249 10.2 µM 1.15863603879145 0.113586856888649 no 445 0.123302286216723 141 53329
SGTC_2252 omeprazole 400 µM 1.15841324505282 0.113631263224137 no 446 0.123347718284713 123 4594 A proton pump inhibitor.
SGTC_469 w7 172 µM 1.15506445082096 0.114300222729699 no 447 0.124032017227381 122 45115570 A P450 inhibitor.
SGTC_1529 apigenin 74 µM 1.15288549441081 0.114736997082734 no 448 0.124478693336523 153 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1141 3253-0389 52.6 µM 1.14863107247043 0.115593221008445 no 449 0.125354069395271 158 5402031
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.14809006357218 0.115702426253297 no 450 0.125465692850491 150 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3268 9137683 49.47 µM 1.14782560805689 0.115755834526631 no 451 0.125520281770084 182 1953228
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.14718676230672 0.115884925236945 no 452 0.125652220715699 146 97141
SGTC_1452 4194-0072 190 µM 1.14717319316375 0.115887668243809 no 453 0.125655024160177 156 1343545
SGTC_1430 4049-0248 69.1 µM 1.14581794302629 0.116161864802936 no 454 0.125935244652708 159 22774488
SGTC_1837 st055472 66.5 µM 1.14480028959116 0.116368060666277 no 455 0.126145947681676 146 676091
SGTC_3006 9075424 71.4286 µM 1.14414548090678 0.116500874528364 no 456 0.126281654320419 160 7465181
SGTC_1772 st048439 82.2 µM 1.14157933383216 0.11702239846207 no 457 0.126814459142652 149 2927068 YDL195W SEC31
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.14151530084978 0.117035433153153 no 458 0.126827774188044 164 5106787 A p450 inhibitor.
SGTC_940 3232-1287 54.8 µM 1.14142203491092 0.117054420407976 no 459 0.126847169687978 143 1585493 YIL048W NEO1
SGTC_890 0929-0006 47.2 µM 1.14111056248641 0.117117846364774 no 460 0.126911958173514 138 1378169
SGTC_312 4092-0653 6.84 µM 1.14098066102683 0.117144305737673 no 461 0.126938985409093 178 1148278
SGTC_3037 9091026 49.47 µM 1.13946928939771 0.117452465361523 no 462 0.12725373515935 155 25236398 YIL048W NEO1
SGTC_236 1509-0011 5.31 µM 1.13804417454856 0.11774356312729 no 463 0.127551018511002 198 3107280
SGTC_1469 k284-2957 126 µM 1.13637671854399 0.118084809898486 no 464 0.127899467586353 150 23884841
SGTC_2483 5729050 27.16 µM 1.13473278426521 0.118421927106567 no 465 0.128243648283229 159 2865180
SGTC_1347 1493-0251 600 nM 1.13357560025952 0.118659635342584 no 466 0.128486306361776 149 3986378
SGTC_143 4032-1194 15.74 µM 1.12937638460851 0.119525067132983 no 467 0.129369545288362 173 1806963
SGTC_1226 3909-7979 35.4 µM 1.12900209922333 0.119602420557262 no 468 0.129448474063463 169 6615510
SGTC_1605 st000082 49.1 µM 1.12678740396115 0.120060853458334 no 469 0.129916188686898 168 1114022
SGTC_43 0570-0105 72.5 µM 1.12440059834611 0.120556297459086 no 470 0.130421559170215 146 1114046 YDL195W SEC31
SGTC_2663 amphotericin b 100 µM 1.12211303688728 0.121032490157072 no 471 0.130907190739605 173 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2229 7354935 190 µM 1.12184818672049 0.121087708334468 no 472 0.130963496986072 177 318112
SGTC_2818 7996756 12.99 µM 1.12069818721626 0.121327675374798 no 473 0.131208177048941 163 2241621
SGTC_3141 9094609 49.47 µM 1.11825988792668 0.121837573823486 no 474 0.131728006580831 194 25236309 YDL196W YDL196W
SGTC_2735 sertaconazole 140 nM 1.11568445799151 0.12237778193103 no 475 0.132278612796708 168 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2303 7774051 200 µM 1.11422115578593 0.122685464038746 no 476 0.132592160826385 159 2953184
SGTC_3057 9095946 49.47 µM 1.11367687922023 0.122800045007594 no 477 0.132708915832373 172 24540043
SGTC_2151 5563267 85.4165 µM 1.11168214690643 0.123220617015312 no 478 0.133137419286355 172 5310824
SGTC_3221 9128209 49.47 µM 1.11145140765568 0.123269331440318 no 479 0.133187047495533 160 16460723
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.10555786610972 0.124518171646632 no 480 0.134458967573321 162 16623 A steroid.
SGTC_943 3253-1379 105 µM 1.10399413360122 0.124851005934411 no 481 0.134797841235656 176 668464
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.10310646343729 0.125040219369886 no 482 0.134990467157678 188 5393153
SGTC_298 1391-0729 10 µM 1.10218551480547 0.125236737955134 no 483 0.135190514019078 154 3237558
SGTC_2924 9010168 62.78 µM 1.10170357278229 0.125339664090709 no 484 0.135295281602238 152 2993929
SGTC_1219 1469-0211 33.1 µM 1.09737619383656 0.12626648836397 no 485 0.136238487842982 172 6822282
SGTC_1098 clofazimine 15.1 µM 1.09572212270022 0.126622010675849 no 486 0.136600199130365 180 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1484 3473-2379 286 µM 1.09340903749195 0.127120348237079 no 487 0.13710712364531 141 671917
SGTC_909 3448-9333 149 µM 1.09209918135219 0.127403151766665 no 488 0.137394754614646 155 3344074
SGTC_1728 st035614 33.7865 µM 1.09020697930917 0.127812458390191 no 489 0.137810989822865 179 15945546
SGTC_127 0180-0333 59.125 µM 1.08747705434924 0.128404583654326 no 490 0.138413016920038 130 771601
SGTC_3263 9137018 49.47 µM 1.08730962909114 0.128440960348085 no 491 0.138449997257764 180 43844957
SGTC_2462 5162487 171.77 µM 1.08430921955054 0.129094076086001 no 492 0.139113859427896 162 2259986
SGTC_3301 9125354 19.7965 µM 1.08428765237502 0.129098779052539 no 493 0.13911863915008 155 41905162
SGTC_604 1000-0114 314 µM 1.08257470222377 0.129472686648837 no 494 0.139498620559032 158 1572745
SGTC_3023 9089636 49.47 µM 1.07902709303345 0.130249453224081 no 495 0.140287825040699 165 17249241
SGTC_1372 2752-0194 270 µM 1.07781468088976 0.130515654605804 no 496 0.140558233285122 145 823334
SGTC_1915 st067105 30.6 µM 1.07281887015292 0.131616519940394 no 497 0.141676196256854 183 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2680 butyl paraben 22.24 µM 1.07254900103532 0.131676169572805 no 498 0.141736758590708 191 7184 An antifungal and steroid mimetic.
SGTC_2475 5812728 15.03 µM 1.07148948026178 0.131910537642161 no 499 0.141974699135832 159 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_971 1315-0384 26.7 µM 1.07085477532727 0.132051073349586 no 500 0.142117366647018 170 6769120
SGTC_1412 3909-8563 178 µM 1.06817074530807 0.132646509792137 no 501 0.142721749234424 181 23767530
SGTC_3300 9124615 50.48 µM 1.06473939473989 0.13341042493484 no 502 0.143496938753572 163 24824903
SGTC_2947 9072639 7.68 µM 1.06453718928532 0.133455535785957 no 503 0.143542708275197 173 16488146
SGTC_2686 alizarin 95.37 µM 1.06130646435675 0.134177714703018 no 504 0.144275324462218 144 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2125 5246583 200 µM 1.06052736897485 0.134352270487537 no 505 0.144452372765947 185 835267
SGTC_2972 9093619 59.92 µM 1.05929765805316 0.134628103557879 no 506 0.14473212059984 138 25236256
SGTC_1263 0774-1208 64.8 µM 1.05912498816302 0.134666865762425 no 507 0.144771430593401 194 906585
SGTC_3247 9135149 49.47 µM 1.05888650877079 0.134720413960306 no 508 0.144825734587494 196 8934436 YOR116C RPO31
SGTC_234 nsc-17383 10.7 µM 1.05603647294193 0.135361492215411 no 509 0.145475775919909 168 408974
SGTC_736 0958-0254 92.6 µM 1.05457480765674 0.135691084553017 no 510 0.145809915279653 183 6812352
SGTC_2074 5212007 75.395 µM 1.05297502415566 0.136052450916423 no 511 0.146176219532178 168 758611
SGTC_96 0929-0093 37.281 µM 1.04900869377832 0.13695122302815 no 512 0.14708705857479 195 6991579
SGTC_1112 tnp00069 1.16933 µM 1.04869099746807 0.137023388254244 no 513 0.147160179486457 171 145826
SGTC_2322 7413319 38.22 µM 1.04592906798136 0.137651859797853 no 514 0.147796891305047 189 1840400
SGTC_1930 st074634 34.3 µM 1.0458551427762 0.137668708320464 no 515 0.147813958704167 170 684253 YOR116C RPO31
SGTC_101 0490-5701 117.494 µM 1.04479480629375 0.137910527769051 no 516 0.148058907916623 153 4661669
SGTC_476 mead acid 10 µM 1.04467418725779 0.137938054389681 no 517 0.148086789419736 161 5312531 An omega 9 fatty acid.
SGTC_196 k015-0023 18.111 µM 1.0405643604401 0.138878202851665 no 518 0.149038889563937 153 5211998
SGTC_406 estrone 100 µM 1.04030915812579 0.138936725510375 no 519 0.149098145369657 168 5870 A steroid.
SGTC_331 k048-0133 24.5 µM 1.0402609867844 0.138947773982524 no 520 0.149109332110437 166 6813582
SGTC_2182 6325192 200 µM 1.03982562962336 0.139047653669679 no 521 0.149210459719967 169 736248
SGTC_1085 doxorubicin 7.67 µM 1.03726667844047 0.139635716317668 no 522 0.149805795266623 196 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1075 aripiprazole 15.2 µM 1.03479939743019 0.140204311779456 no 523 0.150381302199788 167 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2286 7945697 125 µM 1.0324415021518 0.140749166561449 no 524 0.150932669136543 168 1245733
SGTC_621 3584-0052 32.1 µM 1.03229580830806 0.140782880089629 no 525 0.150966782063633 177 2273927
SGTC_1694 st024011 44.9 µM 1.02920145852593 0.141500206144912 no 526 0.151692508544385 187 2787533
SGTC_1088 bifonazole 369 nM 1.02912431098743 0.141518121921636 no 527 0.151710631746788 169 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1466 k213-0079 57.5 µM 1.02904778690163 0.141535894433902 no 528 0.151728609911627 205 3657981
SGTC_2283 7944793 200 µM 1.02903870423592 0.141538003958879 no 529 0.151730743839165 192 2970533
SGTC_299 1273-0059 1.44 µM 1.02826539723262 0.141717689093773 no 530 0.151912501647138 183 2848077
SGTC_2993 9054257 71.4286 µM 1.02788684916741 0.141805704592827 no 531 0.152001528163594 190 6470217 YGL055W OLE1
SGTC_3222 9128301 49.47 µM 1.02487256592816 0.142507870814335 no 532 0.152711660388039 185 4911358
SGTC_2726 cimetidine 79.27 µM 1.02468470234199 0.142551710657712 no 533 0.152755991730707 199 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2397 5161689 200 µM 1.0237664010864 0.142766136668535 no 534 0.152972811831271 171 2259942
SGTC_263 alizarin 107.927 µM 1.02198597494361 0.143182492239039 no 535 0.153393769233242 209 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3286 9117135 37.221 µM 1.01890423682707 0.143905098487711 no 536 0.154124216043995 199 3438150
SGTC_3135 9127742 49.47 µM 1.01832823942081 0.144040430798669 no 537 0.154260996223042 178 3643468
SGTC_2291 7917025 104.35 µM 1.01760929895253 0.144209468393643 no 538 0.154431833211234 166 2964612
SGTC_2196 6573537 42.6665 µM 1.01546390747266 0.144714688501933 no 539 0.154942371411111 192 2903087
SGTC_2119 5528445 120.635 µM 1.01491376212924 0.144844434519212 no 540 0.155073468709869 166 791935
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.01446988998304 0.144949174192509 no 541 0.155179294925978 191 1377
SGTC_1669 st015249 58.4 µM 1.01291721266443 0.145315957592213 no 542 0.15554985300233 171 722793
SGTC_2561 acetosyringone 100 µM 1.01051825421416 0.14588388160445 no 543 0.156123529147146 205 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2805 7950783 58.44 µM 1.01019808045867 0.145959791486981 no 544 0.156200199376429 177 1178958 YDL195W SEC31
SGTC_3317 9138495 8.753 µM 1.00629430499982 0.146887470745587 no 545 0.157137009590102 193 17020139
SGTC_1816 st051957 91.6 µM 1.00571875497926 0.147024576179946 no 546 0.1572754393487 177 674121
SGTC_87 0100-0052 35.5 µM 1.00401705076194 0.147430451802471 no 547 0.157685197547026 199 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2128 5255449 168.493 µM 1.00088139005347 0.148180306793017 no 548 0.15844207732891 160 736008
SGTC_372 0155-0182 15.9 µM 1.00072394704701 0.148218024529777 no 549 0.158480143348319 173 771486
SGTC_3116 9124943 49.47 µM 0.999198661756396 0.148583761089906 no 550 0.15884923201674 175 41905195 YPL160W CDC60
SGTC_2145 5634607 200 µM 0.997109698446931 0.149085635992858 no 551 0.159355632983654 165 308662
SGTC_2040 5100729 123 µM 0.991455010529274 0.150449853892782 no 552 0.160731725086459 173 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_266 formosanin C 406 nM 0.99094088992306 0.150574298843339 no 553 0.16085722218746 203 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_404 fumagillin 50 µM 0.989573242394756 0.150905677084716 no 554 0.161191376983557 194 12015870 A methionine aminopeptidase binder.
SGTC_1151 3909-8316 15.3 µM 0.989535600757914 0.150914804436285 no 555 0.161200580294374 195 800431
SGTC_3245 9134821 49.47 µM 0.987907061526998 0.151310044805777 no 556 0.161599083380928 198 17014901
SGTC_527 4476-4215 268 µM 0.987537883253602 0.151399738627589 no 557 0.161689510415576 162 4418754
SGTC_126 0417-1624 672.48 µM 0.98693822469477 0.151545504200915 no 558 0.161836461886635 232 41912 YDL195W SEC31
SGTC_2837 9008476 45.46 µM 0.982146578034612 0.152713612755058 no 559 0.163013820763749 165 2992805
SGTC_2853 9015042 58.44 µM 0.981775201821245 0.152804395633661 no 560 0.163105303792132 175 6457456
SGTC_833 3852-0053 558 µM 0.981405351632948 0.152894841038686 no 561 0.16319644406302 202 3123681
SGTC_3350 9150499 3.57 µM 0.97902920692643 0.15347676433766 no 562 0.163782774245557 197 4910996 YPR165W RHO1
SGTC_3000 9075062 71.4286 µM 0.975911273196896 0.15424257599006 no 563 0.164554217570992 180 17057871
SGTC_1140 3229-1848 2.98 µM 0.973281761150805 0.154890384912258 no 564 0.16520664234316 189 2849525
SGTC_3172 9105863 49.47 µM 0.973232306532417 0.154902585788347 no 565 0.165218928857781 184 2348785
SGTC_318 1488-0629 67.2 µM 0.969397668964413 0.15585055646111 no 566 0.16617340746693 185 3662576
SGTC_1475 4092-1048 11.7 µM 0.96770525463242 0.156270156573551 no 567 0.166595796546845 182 2881759
SGTC_695 3505-6186 243 µM 0.965820721259742 0.156738263633891 no 568 0.167066948962261 211 1819379
SGTC_2333 9017922 200 µM 0.965464295926031 0.156826901270556 no 569 0.167156155427262 174 3163164
SGTC_1297 1068-0111 14.1 µM 0.964640628262709 0.157031861230384 no 570 0.167362421193549 193 767057
SGTC_1949 st076024 69.1 µM 0.964319285048658 0.157111871447202 no 571 0.167442937556295 227 2921930
SGTC_1849 st056239 19.2 µM 0.961736904534337 0.157755823384779 no 572 0.168090889688408 200 5393181
SGTC_3140 9094243 49.47 µM 0.960868984812042 0.157972639745742 no 573 0.168309023570701 222 19291112
SGTC_1040 k898-0338 155 µM 0.960224330830084 0.158133808315684 no 574 0.168471161961589 215 20969351
SGTC_209 4077-0173 175.592 µM 0.959508792960448 0.158312824747068 no 575 0.168651246082822 186 15993494
SGTC_3217 9129673 49.47 µM 0.954948119672008 0.15945695760546 no 576 0.169801966848779 196 17248312
SGTC_1863 st057641 20.1 µM 0.954945314788152 0.159457662926135 no 577 0.169802676105296 217 3921635
SGTC_1820 st053765 18.6 µM 0.954905264847756 0.159467734172335 no 578 0.169812803534418 204 3690829
SGTC_3248 9135562 49.47 µM 0.953724405353249 0.159764868733619 no 579 0.170111581556572 190 17650701
SGTC_1289 0976-0073 69.1 µM 0.953152910505974 0.159908801496477 no 580 0.170256300609282 196 3391136
SGTC_479 n-linoleoylglycine 10 µM 0.952767457743461 0.160005926856252 no 581 0.17035395294339 210 6433346 An anti-infammatory.
SGTC_2113 5491891 107.031 µM 0.950044140363139 0.160693239990835 no 582 0.171044912284597 195 789979
SGTC_486 niguldipine 82 µM 0.948355315732847 0.161120434107647 no 583 0.171474299655545 203 1236 A calcium channel blocker.
SGTC_2897 9048598 12.99 µM 0.947914458703503 0.161232072297847 no 584 0.171586501811723 168 6467404
SGTC_2068 5226020 147 µM 0.947633271487144 0.161303303664797 no 585 0.171658091032488 197 1810509
SGTC_482 fipronil 114 µM 0.946100012953249 0.161692075349845 no 586 0.17204878858902 180 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1755 st041960 45.185 µM 0.945538901574241 0.161834502774828 no 587 0.172191910052532 210 2257073
SGTC_2122 5258151 111.688 µM 0.94462034410107 0.162067837466357 no 588 0.17242636845685 182 2173356
SGTC_2778 tioconazole 65.09 nM 0.944275462574808 0.162155501842359 no 589 0.172514450747726 208 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1433 4060-0023 7.6 µM 0.943262481235615 0.162413166960986 no 590 0.172773330741212 208 3840627
SGTC_1749 st037932 54.2 µM 0.94243534064598 0.162623758559029 no 591 0.172984900359611 203 594497
SGTC_1413 3910-0535 34.4 µM 0.941882889539471 0.162764512585412 no 592 0.173126300606679 194 2876951
SGTC_1989 st071868 50.2 µM 0.941798534378666 0.162786011645473 no 593 0.173147897845924 205 16414057
SGTC_1399 3562-5772 25 µM 0.940186477792785 0.163197221054199 no 594 0.173560958329466 184 23847490
SGTC_1059 3448-6867 171 µM 0.940107721886359 0.163217327683592 no 595 0.173581154165763 205 3934407
SGTC_2961 9083290 32.55 µM 0.936344767695951 0.164179897351398 no 596 0.174547852774012 201 17741490
SGTC_2728 chlorpromazine 9.18 µM 0.935936275892027 0.164284611284887 no 597 0.174652999185911 245 2726 A thorazine and dopamine antagonist.
SGTC_385 1494-0393 12.4 µM 0.932605769581904 0.165139978054716 no 598 0.17551177667411 211 3090647
SGTC_397 arbidol 50 µM 0.93229398962847 0.165220199135268 no 599 0.175592306509265 194 131410 A RNA synthesis inhibitor.
SGTC_2984 9022109 38.96 µM 0.927549994606126 0.166443941275245 no 600 0.176820523475477 229 6459207
SGTC_3206 9114350 49.47 µM 0.926630740058075 0.166681743646573 no 601 0.177059144412429 188 17087243
SGTC_2083 5306046 65.942 µM 0.924652287716291 0.167194293701683 no 602 0.177573402630865 201 539837
SGTC_2733 amorolfine 100 µM 0.923852799085801 0.167401702091402 no 603 0.177781480502463 228 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3282 9108498 15.4605 µM 0.922444789059081 0.167767379871571 no 604 0.178148308205767 204 16459645
SGTC_1717 st033143 58.0435 µM 0.92202106627932 0.167877526575332 no 605 0.17825879368463 187 674616
SGTC_3280 9140961 49.47 µM 0.921968099829833 0.167891298472469 no 606 0.178272607692574 220 4901226
SGTC_3074 9116018 49.47 µM 0.921674663193844 0.167967608609338 no 607 0.178349150171095 230 17027303
SGTC_1471 k673-0312 37 µM 0.921005300391544 0.16814176436147 no 608 0.178523829869396 208 24099884
SGTC_2679 rapamycin 1 nM 0.92089220540855 0.168171201042069 no 609 0.178553354244211 206 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.920730542002785 0.168213285005387 no 610 0.178595563144461 228 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1984 st072354 53.1 µM 0.919902814005463 0.168428863992055 no 611 0.178811774118636 219 5762938
SGTC_3112 9123419 49.47 µM 0.919393449824454 0.168561614452353 no 612 0.178944907083667 227 17015854
SGTC_966 1300-0360 30.2 µM 0.918350989633368 0.168833509997399 no 613 0.179217570233134 222 70588
SGTC_2013 4024628 200 µM 0.917879118157548 0.168956676598089 no 614 0.179341077561186 218 5230760
SGTC_2110 5483698 200 µM 0.9157060051432 0.169524641336389 no 615 0.179910557252793 201 2848765 YHR062C RPP1
SGTC_47 0149-0135 24.25 µM 0.91502875692757 0.169701896995712 no 616 0.180088266822842 219 5239155
SGTC_3082 9117008 49.47 µM 0.91376365565862 0.170033329293647 no 617 0.180420523800064 195 41448529
SGTC_2529 gangaleoidin 93.61 µM 0.913325896895468 0.170148110258683 no 618 0.180535583074555 206 4565183
SGTC_1955 wogonin 32.4 µM 0.91315641176672 0.170192562828411 no 619 0.180580142421978 175 5281703 A flavanone.
SGTC_603 3794-0023 45.9 µM 0.913063726974067 0.17021687534852 no 620 0.180604513104585 211 3802260
SGTC_1432 4049-0298 68.4 µM 0.911836997619475 0.170538873270978 no 621 0.180927265505924 200 741646
SGTC_3070 9117005 49.47 µM 0.911770114632563 0.170556440249343 no 622 0.180944872799657 176 8779016
SGTC_2571 chrysanthemic acid 100 µM 0.911219560868498 0.170701088547526 no 623 0.181089849734612 208 2743 An insecticide.
SGTC_2269 7935389 174.42 µM 0.910194983206699 0.170970487244435 no 624 0.181359844713214 211 97605
SGTC_683 panaxydol 45 µM 0.90947758696894 0.171159278589884 no 625 0.181549041703911 176 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2455 5377712 9.75 µM 0.908395027712061 0.171444419193642 no 626 0.181834775916481 194 2243908
SGTC_2189 6047310 154.431 µM 0.907904490172436 0.171573724182486 no 627 0.18196434254855 196 711535
SGTC_1462 k081-0014 26.5 µM 0.906695708711424 0.171892623120112 no 628 0.182283866678466 178 3270634
SGTC_1775 st081588 35.1725 µM 0.904551880855502 0.172459134827665 no 629 0.182851418710413 207 1426443 YGL099W LSG1
SGTC_3204 9114183 49.47 µM 0.903693045598098 0.172686417825554 no 630 0.18307909386817 189 17027248
SGTC_2772 vinpocetine 57.06 µM 0.903072121788949 0.172850858585602 no 631 0.183243809377747 208 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_284 0988-0104 32.6 µM 0.902499238761513 0.173002665067898 no 632 0.183395862816117 222 4666532
SGTC_1847 st056231 15 µM 0.901039536178378 0.173389850893185 no 633 0.183783649505918 210 5393180
SGTC_2423 st077119 87.2 µM 0.898394816916487 0.174092766073256 no 634 0.184487549373064 203 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_68 0986-0284 82.829 µM 0.898293416279154 0.17411975240689 no 635 0.184514570789888 203 423278 YIL048W NEO1
SGTC_386 1509-0011 3.07 µM 0.898283100770174 0.174122497881503 no 636 0.18451731982246 196 3107280
SGTC_73 0327-0325 16.231 µM 0.89808710623429 0.174174667091302 no 637 0.184569556245299 172 53298
SGTC_3094 9117742 49.47 µM 0.897724615213412 0.174271179986385 no 638 0.184666191506981 250 17149698
SGTC_2673 kobusone 100 µM 0.897509805111282 0.174328389007618 no 639 0.184723471851104 249 6710676 An epoxy ketone and protein crosslinker.
SGTC_2426 5582046 32.21 µM 0.895665490960279 0.174820064502554 no 640 0.185215723214473 200 2251934
SGTC_2567 aureobasidin a 60 nM 0.895656060911007 0.174822580717839 no 641 0.185218242206105 237 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2326 6164455 177.58 µM 0.894557280603945 0.175115925085872 no 642 0.185511898352454 216 2888790
SGTC_3320 9137005 35.139 µM 0.894517626697737 0.175126517431136 no 643 0.185522501514886 218 4908713
SGTC_1025 k007-0731 70 µM 0.893733092421509 0.175336165660461 no 644 0.18573235752835 195 6256118
SGTC_3154 9100113 49.47 µM 0.892713946973003 0.17560874569285 no 645 0.186005189765273 210 25237525
SGTC_2485 5633444 17.78 µM 0.892195020988901 0.175747640443596 no 646 0.186144205235286 215 5724239
SGTC_660 4031-1742 102 µM 0.89197435342426 0.175806724991558 no 647 0.186203339542981 209 6738706
SGTC_484 loperamide 105 µM 0.8908956926454 0.17609572140364 no 648 0.186492565658195 167 3955 An opioid-receptor agonist.
SGTC_3026 9090633 49.47 µM 0.890547703747975 0.176189019234493 no 649 0.18658593279876 213 25236842
SGTC_605 1315-0399 119 µM 0.88923934414428 0.176540077862596 no 650 0.186937231067313 223 24020461
SGTC_3050 9093513 49.47 µM 0.889091294397582 0.176579830366925 no 651 0.18697700860319 228 25236664
SGTC_728 3030-5151 22.5 µM 0.884758307120898 0.177745777570381 no 652 0.188143500312532 211 3125388
SGTC_2461 5755302 26.15 µM 0.883954549813853 0.177962590436244 no 653 0.188360374126369 227 2788904
SGTC_1583 clindamycin 39.6 µM 0.883633471365637 0.178049247678002 no 654 0.188447052205808 221 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_508 roscovitine 141 µM 0.882756331949698 0.17828611818916 no 655 0.188683969424398 229 160355 A CDKinase inhibitor.
SGTC_2197 6588183 93.1375 µM 0.882491654462113 0.178357633030687 no 656 0.188755495420559 192 884136
SGTC_2552 juarezic acid 87.02 µM 0.879771330699419 0.179093701309719 no 657 0.189491599283462 197 1549512
SGTC_1818 st052136 56.3 µM 0.879761867946799 0.179096265082842 no 658 0.189494162928651 218 674169
SGTC_2654 protoveratrine a 100 µM 0.87968556006806 0.179116940258566 no 659 0.189514837008888 238 5702278 A heart drug and vasodilator.
SGTC_3348 9149464 3.537 µM 0.877339363357476 0.179753361262898 no 660 0.190151168867046 189 1951442
SGTC_2790 5423970 71.43 µM 0.876415821094053 0.180004267248243 no 661 0.190402010266744 215 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_758 0868-0029 16 µM 0.875286688054214 0.180311326326752 no 662 0.190708967717229 202 762687
SGTC_1524 corynanthine 62.1 µM 0.874544543759325 0.180513325685832 no 663 0.190910886688721 207 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_255 tunicamycin 200.472 nM 0.874415345775239 0.180548505733275 no 664 0.190946051639425 210 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1307 1187-1599 12.2 µM 0.873170600326885 0.180887664747168 no 665 0.191285048450505 229 1538471
SGTC_3120 9124077 49.47 µM 0.873165558595597 0.180889039292189 no 666 0.191286422276785 232 18774327 YGL155W CDC43
SGTC_2373 9071805 200 µM 0.868615856413616 0.182132108337913 no 667 0.19252863932165 227 10149009
SGTC_1164 k060-0068 93.7 µM 0.868585918160791 0.182140305708058 no 668 0.192536829738037 229 5963676
SGTC_3278 9139605 49.47 µM 0.868571413802071 0.182144277218375 no 669 0.192540797873084 229 7958859
SGTC_1647 st011722 22.4 µM 0.868469718277259 0.18217212449411 no 670 0.192568621367263 211 2854783
SGTC_269 exalamide 29 µM 0.865880005653092 0.182882161787128 no 671 0.19327798442775 205 3316 A derivative of salicylamide.
SGTC_2142 5622915 118.518 µM 0.865409619223154 0.183011315612457 no 672 0.19340700160366 210 5322196
SGTC_1943 st076331 65.2 µM 0.865054235211253 0.183108930997936 no 673 0.193504510854121 206 24208415
SGTC_256 clotrimazole 625 nM 0.864800227222005 0.183178720743844 no 674 0.193574223213791 209 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1851 st056236 18.9 µM 0.862944562223977 0.183689075585268 no 675 0.194083974062045 212 5393171
SGTC_3185 9108267 49.47 µM 0.857137356292341 0.185291920849244 no 676 0.195684489015873 233 4910486
SGTC_3121 9125696 49.47 µM 0.857051444882224 0.185315698235801 no 677 0.195708226910755 241 1235365
SGTC_2356 9061756 188.97 µM 0.856352248845391 0.185509282608414 no 678 0.195901484428882 203 20104043
SGTC_2185 6113692 200 µM 0.856176455871259 0.185557973635178 no 679 0.195950091750262 225 874150
SGTC_292 k038-0015 474 µM 0.855897109026862 0.185635363260517 no 680 0.196027347099492 226 46368540
SGTC_2512 diallyl trisulfide 49.23 µM 0.85427909783235 0.186084007295089 no 681 0.196475182887899 262 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2034 5197015 53.07 µM 0.852991466209862 0.186441523143749 no 682 0.196832018322882 236 780676
SGTC_1243 0416-0003 5.65 µM 0.852019098552043 0.186711786503186 no 683 0.197101745989957 207 2141977
SGTC_761 k216-0224 480 µM 0.850875984582534 0.187029817673667 no 684 0.197419123314247 235 1340404
SGTC_455 paf C-16 10 µM 0.850160922106815 0.187228928877965 no 685 0.197617812268644 200 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1594 piperine 70.1 µM 0.849415931573027 0.187436512998464 no 686 0.197824945618312 204 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2131 toluylene red 5.2905 µM 0.848357787484875 0.187731598611984 no 687 0.198119371941524 187 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2035 5154463 94.595 µM 0.848027471060466 0.187823772995027 no 688 0.198211335937672 253 2769623
SGTC_148 3253-0744 288.01 µM 0.846479494715905 0.188256106136691 no 689 0.198642654085251 226 6893655
SGTC_2246 7293507 91.5585 µM 0.845750029958187 0.188460050467465 no 690 0.198846103504837 229 887656
SGTC_3122 9126309 49.47 µM 0.843062182826839 0.189212696215255 no 691 0.199596833735249 260 17591206
SGTC_1986 st071812 45 µM 0.841219820588891 0.189729658416415 no 692 0.200112399332162 225 11838594
SGTC_3330 9141424 71.43 µM 0.840837768129444 0.189836970022189 no 693 0.200219412798066 201 27261020
SGTC_1488 4013-0813 75.9 µM 0.839281668255422 0.190274435696233 no 694 0.200655633870236 215 2910057
SGTC_3085 9117376 49.47 µM 0.834313369421866 0.191675311478167 no 695 0.202052209985492 240 16480349
SGTC_3109 9122853 49.47 µM 0.834124603403527 0.191728660742598 no 696 0.202105386086041 253 1234709
SGTC_664 1222-0054 14.9 µM 0.833082663140809 0.192023298654129 no 697 0.20239905524837 224 6813991
SGTC_448 monastrol 171 µM 0.829922271345355 0.192918681821273 no 698 0.203291365998634 253 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_389 tpck 16.7 µM 0.828886400401241 0.193212712528637 no 699 0.203584345756368 208 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2956 9076196 2.52 µM 0.827655808763097 0.193562369742666 no 700 0.203932726256967 257 16423868
SGTC_2295 7971645 200 µM 0.824204778675905 0.194544993577383 no 701 0.204911606124355 211 2978226 YKL099C UTP11
SGTC_447 ml7 120 µM 0.824095449102253 0.194576172898606 no 702 0.20494266289042 241 4216 Selective myosin light chain kinase inhibitor.
SGTC_2801 7907800 81.82 µM 0.82002878516393 0.19573808986496 no 703 0.206099848864341 243 6620925
SGTC_2492 derrusnin 100 µM 0.818147519022532 0.196277022270126 no 704 0.206636478962236 241 1715307 Part of coumarin class of compounds.
SGTC_2100 5377183 190 µM 0.816445970914293 0.196765244249303 no 705 0.20712255652709 221 2844202
SGTC_2603 homopterocarpin 100 µM 0.816378984926341 0.196784479446495 no 706 0.207141706097111 233 101795 A weak amylase inhibitor.
SGTC_471 1-acyl-paf 4 µM 0.815994827007667 0.196894813361385 no 707 0.2072515471829 225 16759367
SGTC_897 1000-0139 31.4 µM 0.815518574639472 0.197031649689519 no 708 0.20738776835976 235 6151020
SGTC_1531 st059297 52.4 µM 0.813533779369063 0.197602538472254 no 709 0.207956043676872 243 7566702
SGTC_211 3455-0679 143.504 µM 0.813222228068951 0.197692241011629 no 710 0.208045328684759 209 748649
SGTC_1177 0983-0204 23.6 µM 0.813198029842855 0.197699209248212 no 711 0.208052264408705 233 766818
SGTC_2031 5180455 200 µM 0.812157287235473 0.197999046914453 no 712 0.208350692423121 238 29949
SGTC_359 0081-0058 15.9 µM 0.812113433541425 0.198011687179069 no 713 0.208363272803694 235 3494159
SGTC_760 0568-0725 82.9 µM 0.811536657849337 0.198177980723208 no 714 0.208528775080529 246 3916171
SGTC_578 3460-0051 92 µM 0.811047093685444 0.198319195936717 no 715 0.208669313337512 266 2876744
SGTC_75 0159-0059 199.013 µM 0.808901955405837 0.198938678649517 no 716 0.209285772038537 243 5377270
SGTC_2911 7942208 15.64 µM 0.808587770589058 0.199029508170454 no 717 0.209376150749357 219 1243384
SGTC_575 k072-0246 11.9 µM 0.80389179146057 0.200390071964865 no 718 0.210729735563517 232 6796779
SGTC_2852 9023854 51.95 µM 0.803651008377678 0.200459984185744 no 719 0.210799277758575 258 19798528
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.803368690274384 0.200541974902428 no 720 0.210880833105056 271 368090
SGTC_438 sphingosine 6.67 µM 0.802186384319348 0.200885558450585 no 721 0.21122257561841 226 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3267 9137951 49.47 µM 0.802185503011949 0.200885814694241 no 722 0.21122283047903 251 16643986
SGTC_2353 9059630 146.67 µM 0.802178228220902 0.200887929876369 no 723 0.211224934244215 226 4779114
SGTC_747 3448-8087 38.7 µM 0.802075492117671 0.200917802342636 no 724 0.21125464536202 239 5168703
SGTC_2389 9091542 195.52 µM 0.80191870360153 0.200963396708073 no 725 0.211299993071164 237 3626624 YOL127W RPL25
SGTC_3298 9116858 71.43 µM 0.801592929732309 0.201058152145656 no 726 0.211394234394163 253 2506942
SGTC_1220 1838-0075 193 µM 0.801549355631954 0.201070828253772 no 727 0.211406841571273 224 5529645
SGTC_1962 st076595 64.5 µM 0.797377561390087 0.202286660363377 no 728 0.212615893486646 237 279619
SGTC_2030 5175110 200 µM 0.796750078046534 0.202469914474268 no 729 0.212798096809303 246 2831986
SGTC_1084 voriconazole 435 nM 0.795564458734908 0.202816440896658 no 730 0.213142615653894 256 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_290 2043-6722 48.1 µM 0.794994023666052 0.202983290752853 no 731 0.213308489290704 235 773758 YLR208W SEC13
SGTC_3147 9097027 49.47 µM 0.793587570272882 0.203395022506282 no 732 0.213717785446755 264 25236841
SGTC_2815 7968870 71.43 µM 0.79320322099046 0.203507625346149 no 733 0.213829715602396 225 2977326 YHR190W ERG9
SGTC_3077 9117319 49.47 µM 0.787989281085782 0.205038824209486 no 734 0.215351487861634 274 17154678
SGTC_1992 st073643 23.3 µM 0.78725807851569 0.205254105612767 no 735 0.215565402374554 244 3161292
SGTC_2757 clomiphene 4.22 µM 0.786482085082926 0.205482721203207 no 736 0.215792555250163 264 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_993 3909-8757 62.7 µM 0.786293938084746 0.205538173996203 no 737 0.215847651517827 229 4288324 YLR208W SEC13
SGTC_325 2810-4341 181 µM 0.785433568398713 0.205791864984773 no 738 0.216099702833406 229 774970
SGTC_162 k030-0015 37.8 µM 0.784904447521548 0.205947975258324 no 739 0.216254797112434 261 1809920 YMR134W ERG29
SGTC_2033 5192550 145 µM 0.783602276513807 0.206332463003778 no 740 0.216636759800332 234 182073
SGTC_3288 9119690 36.221 µM 0.782323063772126 0.206710585834379 no 741 0.217012367892267 256 17595618 YKL019W RAM2
SGTC_1644 st010134 20.9 µM 0.781232451030007 0.207033284130261 no 742 0.217332895426384 258 3818134
SGTC_2276 7947513 42.08 µM 0.781002052610983 0.207101494177393 no 743 0.21740064373215 251 2105100
SGTC_739 1486-1183 203 µM 0.78093225495935 0.207122160575944 no 744 0.217421170032013 229 4346692
SGTC_421 streptovitacin 30 mM 0.777887104949147 0.208024986655796 no 745 0.218317785455618 243 91467 include heat shock
SGTC_1957 st077035 62.4 µM 0.775346198344246 0.208780089530413 no 746 0.219067558741707 252 705593
SGTC_782 0083-0095 30.5 µM 0.773655987741321 0.209283277157184 no 747 0.219567126811602 249 3591729 An indicator and reagent.
SGTC_1672 st016598 6.51 µM 0.77336170042596 0.20937096147244 no 748 0.219654174843115 245 4665860 YNL267W PIK1
SGTC_1794 st048918 76.9 µM 0.771341729371862 0.209973404741499 no 749 0.220252202064177 207 672303
SGTC_336 4111-0029 111 µM 0.770063201969528 0.210355243106109 no 750 0.220631201426114 247 3131175
SGTC_2617 dihydrotanshinone i 20.83 µM 0.769164731201627 0.210623819468748 no 751 0.220897762342198 248 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_652 0437-0092 114 µM 0.767191731798069 0.211214306033691 no 752 0.221483764051432 236 3091274
SGTC_2082 5219693 150 µM 0.766946034266287 0.211287907156418 no 753 0.221556800993139 251 2834649
SGTC_114 0364-0001 490.298 µM 0.766896435928056 0.211302766651064 no 754 0.221571546445284 250 4003655
SGTC_197 4544-0043 41.561 µM 0.76653334851506 0.211411565057278 no 755 0.221679508434555 246 896523
SGTC_403 arphamenine a 50 µM 0.765102677213708 0.211840582017039 no 756 0.222105202900017 258 5487158 An arginine aminopeptidase inhibitor.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.76342841436504 0.212343291308278 no 757 0.222603969755468 251 676296 Flavone; oxidizing agent.
SGTC_2546 rhodinyl acetate 100 µM 0.763221427744586 0.212405488892673 no 758 0.222665675877847 245 6708682
SGTC_2517 totarol 10 µM 0.762798055585346 0.212532741499073 no 759 0.222791920457281 236 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2864 9034755 47.6 µM 0.762557481435221 0.212605070501954 no 760 0.222863674997794 240 4930451
SGTC_350 k064-0020 19.8 µM 0.762151091465131 0.212727284943498 no 761 0.222984916282794 239 2790705
SGTC_549 1661-1316 519 µM 0.76157498631122 0.212900608430787 no 762 0.223156854295203 259 2857282
SGTC_504 lovastatin 124 µM 0.754916697683154 0.214909753343317 no 763 0.22514948313494 262 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_823 0417-1665 178 µM 0.754173826493866 0.215134596297922 no 764 0.225372425847613 258 3429856
SGTC_2089 5281248 129.67 µM 0.753074295494053 0.215467639097224 no 765 0.225702634863831 237 2737878
SGTC_454 lyso-paf C-16 6.67 µM 0.75206597547584 0.215773317227318 no 766 0.226005692019608 271 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1522 st012842 45.6 µM 0.751765212565619 0.215864543915398 no 767 0.226096132794516 255 3491067 YOR116C RPO31
SGTC_2051 5263410 176 µM 0.750907014445454 0.21612497336767 no 768 0.226354309294068 255 227584
SGTC_2432 5630864 12.22 µM 0.749109168400782 0.21667113858491 no 769 0.226895704717949 267 5714970
SGTC_539 4859-0462 2.54 µM 0.748563610570653 0.216837030600603 no 770 0.227060135927704 248 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_794 k038-0031 316 µM 0.74720226034465 0.217251307056532 no 771 0.22747073994547 259 6624242
SGTC_1264 0783-0040 158 µM 0.745747319057463 0.217694569438068 no 772 0.227910034409127 253 2855798
SGTC_1840 st055363 71 µM 0.745199422698557 0.217861626683394 no 773 0.228075585910155 265 676033
SGTC_2705 st078069 42.8 µM 0.744552484546045 0.218058977589661 no 774 0.228271150765372 237 1530061
SGTC_2366 9070441 60.58 µM 0.741448319531982 0.21900734712938 no 775 0.2292108280761 242 6837235
SGTC_1859 st055998 20 µM 0.737544972301109 0.220203239185302 no 776 0.230395502493781 263 676301
SGTC_470 aa-861 153 µM 0.73638743215426 0.22055860036063 no 777 0.230747475441347 259 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.735799547257668 0.220739204912623 no 778 0.230926348399352 245 136420
SGTC_1885 st057546 99.9 µM 0.735753366818115 0.220753395626522 no 779 0.23094040278217 240 702008
SGTC_1310 1188-0297 994 nM 0.731939652579558 0.221927107651552 no 780 0.232102701174245 246 1588352
SGTC_720 r052-1644 49.9 µM 0.730529599656107 0.222361967485829 no 781 0.232533263421379 252 1422863 YOR257W CDC31
SGTC_2913 7966556 36.57 µM 0.726861850560682 0.223495373674008 no 782 0.233655294630607 247 2976516
SGTC_1134 3477-0009 42.5 µM 0.726618089848023 0.223570816783471 no 783 0.233729971696718 258 3973534
SGTC_3098 9119039 49.47 µM 0.726106828625639 0.223729097426054 no 784 0.233886641575477 264 17161528
SGTC_247 mechlorethamine 29.705 µM 0.725328564425283 0.223970161400909 no 785 0.234125242986404 241 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1612 st002233 45.4 µM 0.724756656598709 0.224147401411512 no 786 0.234300665232552 258 1035021
SGTC_1926 methyl fluorone black 53.6 µM 0.722898507783727 0.224723810014303 no 787 0.234871120196195 227 72721 Reacts with homocysteine.
SGTC_3018 9082602 49.47 µM 0.718498120516219 0.226092182940826 no 788 0.236225103172382 268 17332089
SGTC_2656 pseudo-anisatin 100 µM 0.71767438934403 0.226348857997343 no 789 0.236479039040567 296 6708809 A neurotoxin.
SGTC_1865 st057639 52.2 µM 0.717673688200914 0.226349076543981 no 790 0.236479255249555 275 688818
SGTC_1780 st038448 24.544 µM 0.717054915708994 0.226541994679697 no 791 0.236670106313127 273 728868 YDL195W SEC31
SGTC_559 1550-0661 158 µM 0.715852674709919 0.226917089290463 no 792 0.237041161576928 260 5830875
SGTC_2990 9074105 71.4286 µM 0.713094141627392 0.227779063678286 no 793 0.237893752204641 281 6502001
SGTC_3207 9114163 49.47 µM 0.712544341301728 0.22795108286389 no 794 0.23806388188862 292 849233
SGTC_841 0251-0215 91.2 µM 0.710968991743709 0.228444376006519 no 795 0.238551725608218 261 3888614
SGTC_981 1488-1094 54.9 µM 0.710653750347868 0.228543160302271 no 796 0.238649413121436 265 3449522
SGTC_1123 mangostin 811.285 nM 0.710563255452075 0.228571522287147 no 797 0.238677459869549 213 5281650 An antioxidant.
SGTC_2393 9031399 185.94 µM 0.710472329677771 0.228600021304514 no 798 0.238705641974676 279 1526623 YDL150W RPC53
SGTC_1970 st070122 35.8 µM 0.71016789007885 0.228695456842601 no 799 0.23880001514703 281 102928
SGTC_2436 5633522 8.09 µM 0.710028389781484 0.22873919478295 no 800 0.238843265634969 276 5724242
SGTC_1107 amlodipine 47 µM 0.708504692871651 0.229217229651221 no 801 0.239315949471745 238 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1478 0453-0656 35.7 µM 0.70809547698179 0.229345709778561 no 802 0.239442984114012 279 5258496
SGTC_2330 7979373 200 µM 0.70787895715983 0.22941370610152 no 803 0.239510214183879 259 1863007
SGTC_172 1112-0046 2.638 µM 0.707755488206719 0.229452485599463 no 804 0.239548556286929 275 2802135 YIL048W NEO1
SGTC_1388 3346-4487 254 µM 0.707347113147239 0.229580775425288 no 805 0.23967539712505 270 3345614
SGTC_120 rhodamine 6G 52.259 µM 0.706662592089237 0.229795905811163 no 806 0.239888090789308 289 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1559 coumarin 343 70.1 µM 0.706178927242279 0.229947979398336 no 807 0.240038436671206 273 108770 A hepatotoxic, DNA x-linker.
SGTC_886 0866-0150 153 µM 0.706101062193 0.229972466939679 no 808 0.240062645606969 257 271463
SGTC_2893 9048488 25.97 µM 0.705815978121581 0.230062134610705 no 809 0.240151292135564 282 6467338
SGTC_1173 0443-0020 122 µM 0.704190488537701 0.23057377446966 no 810 0.240657076774378 261 5331295
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.702519271266145 0.231100469883116 no 811 0.241177693911199 280 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_638 3970-0837 4.09 µM 0.70250033777322 0.231106440745289 no 812 0.241183595572692 266 4118451 YLR208W SEC13
SGTC_76 0433-0009 400.328 µM 0.702209035283139 0.231198316685745 no 813 0.241274405864425 276 2841569
SGTC_3169 9102970 49.47 µM 0.701789335546183 0.231330724561074 no 814 0.241405275225053 275 17027839
SGTC_2958 9077254 16.72 µM 0.701615546525283 0.231385564316448 no 815 0.241459476820713 261 16457351
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.7005266556025 0.231729332763738 no 816 0.24179923225657 292 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1055 3448-0672 86 µM 0.699977726705276 0.231902740261031 no 817 0.241970607201178 256 748378
SGTC_569 4130-2812 160 µM 0.699463988922716 0.232065096277523 no 818 0.242131055185749 284 743552
SGTC_1831 st055328 12 µM 0.697686198262105 0.232627417687113 no 819 0.242686730684834 259 1103068
SGTC_463 ikarugamyin 104 µM 0.69730640862984 0.232747644593098 no 820 0.242805529141661 278 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_727 3032-0951 202 µM 0.69637913734235 0.233041328323504 no 821 0.243095712414014 266 3652836
SGTC_3233 9132340 49.47 µM 0.695470352343462 0.233329356666017 no 822 0.243380292401497 306 17682950
SGTC_2221 6807166 181.081 µM 0.693193711048274 0.234051776940647 no 823 0.244093997171564 258 674925
SGTC_576 1073-0113 22.7 µM 0.691009880996828 0.234745909008528 no 824 0.244779665780602 304 5439563
SGTC_2881 9058953 51.95 µM 0.690216628726058 0.234998326359112 no 825 0.245028983835994 236 17122249
SGTC_1054 3429-0080 167 µM 0.688070305297583 0.235682049788833 no 826 0.245704254524857 282 1162877
SGTC_124 0136-0217 7.121 µM 0.687813148369396 0.235764042113413 no 827 0.245785227549463 272 3976905
SGTC_2310 7668677 200 µM 0.686463353729584 0.236194670626692 no 828 0.246210482843273 281 2197143
SGTC_1176 0848-0131 83.3 µM 0.685752266351016 0.236421704802179 no 829 0.246434670803849 282 6769040
SGTC_131 0141-0277 33.849 µM 0.685655655896649 0.236452559609339 no 830 0.246465138088211 280 1547771
SGTC_2126 5251174 33.877 µM 0.681567621343845 0.237760198120961 no 831 0.247756197285661 269 790722
SGTC_2054 5233173 129 µM 0.67884395454382 0.238633613703031 no 832 0.248618370058764 225 6889
SGTC_2600 tangeritin 87.95 µM 0.67800922333006 0.238901643380986 no 833 0.2488829226082 285 68077 A bioactive flavone.
SGTC_2734 clemastine 41.6 µM 0.677911726298224 0.238932960118266 no 834 0.248913832250962 310 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2719 novobiocin 32.65 µM 0.677600522045854 0.239032936145288 no 835 0.249012507509271 295 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_42 0133-0086 60.653 µM 0.676830476712739 0.239280415592634 no 836 0.249256759495883 304 162923 Model of phenazepam hydroxylation.
SGTC_982 1491-0518 27.5 µM 0.676167510632021 0.23949359367994 no 837 0.249467148841571 279 3091256
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.675190829335505 0.239807836357378 no 838 0.249777266158445 271 688664
SGTC_1587 estradiol valerate 56.1 µM 0.674775733762356 0.239941459519189 no 839 0.249909129888089 295 13791 A steroid.
SGTC_2515 chrysin 20.77 µM 0.674377438409083 0.240069712696748 no 840 0.250035691406521 265 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3229 9132204 49.47 µM 0.673908600566217 0.240220728799937 no 841 0.250184711926475 278 17682924
SGTC_2324 6149169 200 µM 0.673380415911655 0.240390922940994 no 842 0.25035265229142 271 2888231
SGTC_1425 4048-4433 7.33 µM 0.672884909768458 0.240550646951833 no 843 0.250510256585221 317 23734946
SGTC_3146 9095609 49.47 µM 0.672538432782122 0.240662366453415 no 844 0.250620490804318 284 17173999
SGTC_1461 k072-0203 53.8 µM 0.672154212050486 0.240786289225279 no 845 0.25074276351508 279 5418714
SGTC_706 4262-0057 46.9 µM 0.671705569254982 0.240931033986944 no 846 0.250885577587108 289 883298
SGTC_122 0236-0016 402.397 µM 0.670348329060302 0.241369205792331 no 847 0.2513178826442 295 6808838
SGTC_2092 5303694 80.6725 µM 0.668395258309452 0.242000494709887 no 848 0.251940660720154 277 1963699
SGTC_725 1497-0963 19 µM 0.668144916727447 0.242081477044542 no 849 0.252020546297185 279 3549977
SGTC_46 0329-0187a 2.197 µM 0.667888803360122 0.242164341683403 no 850 0.252102287516106 284 46494817
SGTC_2253 7938677 135.83 µM 0.667189156734913 0.242390788412112 no 851 0.252325658210263 268 2301972
SGTC_1015 4130-4525 82 µM 0.667143280087341 0.242405640795942 no 852 0.252340308532125 291 1363237
SGTC_2486 5283202 22.39 µM 0.665612926154543 0.242901369288045 no 853 0.252829271052284 272 1377751
SGTC_567 1080-0542 68.4 µM 0.663485265915333 0.243591494017646 no 854 0.253509906461131 252 5950415
SGTC_1338 1486-1223 76 µM 0.663459156143041 0.243599969516765 no 855 0.25351826491479 273 3444526
SGTC_636 0kpi-0074 126 µM 0.66282093951271 0.243807190676699 no 856 0.253722620566667 291 616434
SGTC_2528 xanthyletin 44.79 µM 0.662323610288987 0.243968733345909 no 857 0.253881924304388 302 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1108 betulinic acid 729.144 nM 0.661305265464252 0.244299692601717 no 858 0.254208282694867 262 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2137 5261020 140 µM 0.660790223022255 0.24446717207688 no 859 0.254373426841652 279 763655
SGTC_790 1575-0012 79.1 µM 0.658565310380761 0.245191370672935 no 860 0.25508747249741 294 378741 YLR208W SEC13
SGTC_339 3091-4833 71.4 µM 0.658225752627539 0.245301996496475 no 861 0.255196539584549 283 3240077
SGTC_1786 berberine 21.6 µM 0.656996947862294 0.245702557649904 no 862 0.255591439489442 290 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1253 0550-0034 176 µM 0.652875947278963 0.247048466053942 no 863 0.256918128246367 274 5969915
SGTC_558 k064-0027 21.3 µM 0.651986445817095 0.247339491678508 no 864 0.257204958148718 278 5088526
SGTC_1245 0418-0076 17.2 µM 0.650820490348781 0.247721244447529 no 865 0.25758118578258 305 6790114
SGTC_921 1561-0023 372 µM 0.649593301511332 0.248123385622874 no 866 0.257977480536095 283 24050882
SGTC_869 0564-0080 44.1 µM 0.649545408688079 0.248139086822095 no 867 0.257992952923209 271 6843321
SGTC_773 4358-1457 44.6 µM 0.649487034368346 0.248158224995225 no 868 0.258011812142252 313 1186886
SGTC_907 3448-6986 75.5 µM 0.648985616707162 0.248322648503884 no 869 0.258173836546336 299 590582
SGTC_805 3852-0218 479 µM 0.648408887170316 0.248511839871757 no 870 0.258360261881773 272 6615355
SGTC_848 0368-0089 85.6 µM 0.648099011789563 0.248613523644588 no 871 0.258460456561635 292 762535
SGTC_205 1486-1330 71.903 µM 0.646876066557126 0.249015042121735 no 872 0.258856078370684 282 4118834
SGTC_1364 1653-0028 37.6 µM 0.64570960721256 0.249398336366621 no 873 0.259233718784492 272 5718652
SGTC_1621 st003705 32.4 µM 0.645398180719326 0.249500722977751 no 874 0.259334591036336 291 24207032
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.643786063303694 0.250031090112862 no 875 0.259857086164923 272 77254
SGTC_1322 1348-1070 12 µM 0.642510045334755 0.250451308330923 no 876 0.260271034537932 283 6758089
SGTC_753 1322-0200 289 µM 0.641927153792546 0.250643390629411 no 877 0.260460241268302 276 5403907
SGTC_3355 9151058 44.0485 µM 0.641368863413548 0.250827439154327 no 878 0.260641528845583 290 17015728
SGTC_561 1550-0330 72.9 µM 0.639772442597333 0.25135411699679 no 879 0.261160275403403 295 6812934
SGTC_233 rapamycin 362 pM 0.638238947568862 0.251860584849291 no 880 0.261659073805969 283 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2167 5876490 200 µM 0.63629861834843 0.252502189160813 no 881 0.262290902663026 294 686534
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.636008071186308 0.252598337821519 no 882 0.262385580679712 309 7104
SGTC_2344 7990960 76.95 µM 0.635921854845842 0.252626872478609 no 883 0.262413678597508 292 140813
SGTC_2243 6634756 200 µM 0.635617678995182 0.252727557832188 no 884 0.262512821855691 248 885676
SGTC_3227 9130768 49.47 µM 0.635472913363418 0.252775484174595 no 885 0.262560013585277 305 17720899
SGTC_2943 9068529 45.32 µM 0.634955445486106 0.252946837036571 no 886 0.262728736933978 314 3270634
SGTC_998 3996-0085 177 µM 0.634660884638434 0.253044404384918 no 887 0.262824804941914 302 715391
SGTC_3241 9133421 49.47 µM 0.633505256665774 0.253427374008971 no 888 0.263201874599215 328 17018221
SGTC_249 wiskostatin 11.211 µM 0.632414056040541 0.253789272128293 no 889 0.263558175761193 279 2775510 A n-wasp and actin depolymerizer.
SGTC_878 0828-0289 13.7 µM 0.632193199042043 0.253862552642348 no 890 0.263630320398347 300 745350 YLR208W SEC13
SGTC_1349 flufenamic acid 69 µM 0.63128903535655 0.254162670583253 no 891 0.263925777436338 294 3371 A non-steroidal anti-inflammatory.
SGTC_1293 1000-1278 195 µM 0.630084547311432 0.2545627636801 no 892 0.264319634638615 319 678847
SGTC_2712 st079126 47.7 µM 0.629926327397199 0.254615343871096 no 893 0.264371393412846 288 3152970
SGTC_2207 7258803 200 µM 0.629629338748587 0.254714055527288 no 894 0.26446856179023 306 3666799
SGTC_1481 3346-2004 36 µM 0.628621601519209 0.255049151671622 no 895 0.264798407415287 315 2770522
SGTC_2862 9027634 71.43 µM 0.62861323655569 0.255051934181958 no 896 0.26480114625265 280 5012562
SGTC_2457 5731572 11.68 µM 0.627909006158395 0.255286245376538 no 897 0.265031775402252 312 2865357
SGTC_77 0828-0286 12.516 µM 0.627589230875609 0.25539267799041 no 898 0.265136532623476 286 745345
SGTC_1628 st004252 77.7 µM 0.627337258957701 0.255476559560015 no 899 0.265219092519948 285 692968
SGTC_1928 4'-methoxychalcone 40.3 µM 0.626284575495193 0.255827154005268 no 900 0.265564150802371 302 641818
SGTC_383 2324-0395 7.37 µM 0.625532798275745 0.256077685760313 no 901 0.265810714566894 281 3146421
SGTC_1490 4089-0339 670 nM 0.62504932786803 0.256238871142762 no 902 0.265969341817285 301 742542
SGTC_1387 3342-1166 1.8 µM 0.624813789668511 0.256317416956653 no 903 0.266046639567079 292 3418228
SGTC_1447 4239-0816 81.9 µM 0.623867064137326 0.256633251646741 no 904 0.26635744595799 289 1341554
SGTC_1018 4259-0013 28.1 µM 0.623471964778648 0.256765119647937 no 905 0.26648720989173 295 6801262
SGTC_1453 4237-0541 195 µM 0.62321281099538 0.256851633729517 no 906 0.266572342083193 282 739892
SGTC_2459 5811157 9.22 µM 0.622095803503617 0.257224701213899 no 907 0.26693943711173 304 2870684 YBR192W RIM2
SGTC_2591 skatole 100 µM 0.621707256696743 0.257354537323613 no 908 0.267067189554442 316 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_408 cantharidin 100 µM 0.621240225297201 0.257510644763831 no 909 0.267220788222312 280 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2351 9026858 72.31 µM 0.618751818287063 0.258343234961843 no 910 0.268039933788219 320 1409300
SGTC_3013 9080133 71.4286 µM 0.618684655384242 0.258365726155288 no 911 0.268062060297222 300 17050193
SGTC_912 3474-0017 2.18 µM 0.617530693001861 0.258752317998512 no 912 0.268442371447049 311 3360550
SGTC_2635 hydroquinidine 100 µM 0.616731213976287 0.259020328934378 no 913 0.268706014585635 288 442912 An experimental heart treatment.
SGTC_1952 st077036 64.1 µM 0.614910937965076 0.259631078777308 no 914 0.269306769470207 297 2937007
SGTC_1188 1403-0014 4.57 µM 0.614723434117494 0.25969403339233 no 915 0.269368690554814 292 9614867
SGTC_2652 actinonin 100 µM 0.613795447006908 0.260005721997153 no 916 0.269675253149164 295 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1122 capsaicin 818.572 nM 0.611622102060032 0.260736450635423 no 917 0.270393905722346 308 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1089 terbinafine 2.25 µM 0.610888781016072 0.260983248286188 no 918 0.270636606286606 310 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1236 0330-0013 258 µM 0.610675238320757 0.261055138205344 no 919 0.270707301009173 308 4617066
SGTC_3228 9131799 49.47 µM 0.610508342147193 0.261111331491232 no 920 0.270762559510724 307 17015818
SGTC_3289 9119912 71.43 µM 0.610480650672842 0.261120655703176 no 921 0.270771728566227 306 17014829
SGTC_1914 st062367 72.6 µM 0.609890673125268 0.26131935229403 no 922 0.270967115656245 316 978205
SGTC_972 1319-0219 195 µM 0.607770974358721 0.262033878904669 no 923 0.271669691339325 307 23903702
SGTC_2979 9012552 45.46 µM 0.607328180963415 0.262183265931538 no 924 0.271816569955 312 17100905
SGTC_1738 st035555 74 µM 0.606873930411469 0.262336563639285 no 925 0.27196729006457 318 5331140
SGTC_351 caspofungin 25 nM 0.605516442855766 0.262794953679014 no 926 0.272417951338069 305 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3338 9144300 39.5675 µM 0.604875570526005 0.263011502707328 no 927 0.272630838148117 291 4901274
SGTC_750 4073-0104 132 µM 0.604873652436277 0.26301215096153 no 928 0.272631475428586 289 22330957
SGTC_1867 st057372 64 µM 0.604574827503598 0.263113154394973 no 929 0.272730768287451 286 688837
SGTC_2949 9072542 2.23 µM 0.604286094646058 0.263210765509629 no 930 0.272826724816422 313 16457352
SGTC_320 4092-0846 5.34 µM 0.602600491542561 0.263780981641836 no 931 0.273387246647587 302 1359356
SGTC_2028 5153890 36.43 µM 0.602021092475889 0.263977129683575 no 932 0.273580048653701 302 2830968 YPR165W RHO1
SGTC_2052 5265182 7.135 µM 0.600725129663392 0.264416130013651 no 933 0.274011539283642 299 1239884
SGTC_582 0987-0078 156 µM 0.60045776868985 0.264506743300092 no 934 0.274100598911973 316 1625765
SGTC_1233 0325-0408 14.2 µM 0.599124617378234 0.264958807181681 no 935 0.274544893357212 315 12874
SGTC_381 3461-2219 42.7 µM 0.598386839649423 0.265209151980364 no 936 0.274790922461684 326 2883159
SGTC_908 3448-7491 47.7 µM 0.598021517324846 0.265333158617019 no 937 0.274912787889906 262 1203031
SGTC_1240 0356-0016 42.1 µM 0.597077406481133 0.265653768059172 no 938 0.275227850802577 284 4305613
SGTC_3053 9095903 49.47 µM 0.596656433181324 0.265796789164999 no 939 0.27536839272336 347 17174018
SGTC_3191 9110352 49.47 µM 0.59599228375668 0.266022506047795 no 940 0.275590190765109 318 17122424
SGTC_3144 9087057 49.47 µM 0.595759541750032 0.266101628384108 no 941 0.27566793761125 325 17249618
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.595593409862573 0.266158113414823 no 942 0.275723440119299 304 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1648 st011736 69.8 µM 0.595085417271883 0.266330869127389 no 943 0.275893187920535 301 2855514
SGTC_1365 1672-3266 55.4 µM 0.594106621151023 0.266663893396172 no 944 0.276220401333272 310 6415873
SGTC_1726 st035556 14.5795 µM 0.590494535410299 0.267894683730163 no 945 0.277429574145267 287 5919439
SGTC_2553 4-methylesculetin 85.09 µM 0.589409463145534 0.268264971774502 no 946 0.277793314979911 301 5319502
SGTC_2755 lomerizine 42.69 µM 0.587883820958996 0.268786042371052 no 947 0.278305138396023 307 3949 A calcium channel blocker.
SGTC_2043 5101342 149 µM 0.586447449839198 0.269277087351335 no 948 0.278787432848585 322 678451
SGTC_2282 7944268 200 µM 0.586172723836945 0.269371057779772 no 949 0.278879724708988 306 2970414
SGTC_815 1582-0027 36.9 µM 0.586136595933512 0.26938341660482 no 950 0.278891862676358 326 3128206
SGTC_2942 9052777 62.25 µM 0.585601585952553 0.269566468930524 no 951 0.279071641181435 331 6469503
SGTC_3340 9146634 11.102 µM 0.584368374608387 0.26998864638193 no 952 0.279486249642044 302 4907387
SGTC_445 e6 berbamine 66 µM 0.583035882380412 0.270445183244983 no 953 0.279934572507189 305 6610268 A calcium/calmodulin antagonist.
SGTC_313 3474-0040 5.03 µM 0.583008760157643 0.270454479832433 no 954 0.27994370151827 299 1043375 YIL048W NEO1
SGTC_2346 9031566 143.75 µM 0.582521255474679 0.270621607298847 no 955 0.280107814290911 316 4771086
SGTC_2101 5377231 179.231 µM 0.581468475199061 0.270982699716151 no 956 0.280462379490829 331 2844213
SGTC_1237 0330-0133 46.1 µM 0.581019749102073 0.271136681014304 no 957 0.280613571675678 332 X1237 YHR072W ERG7
SGTC_2191 5911152 200 µM 0.580074385432922 0.271461227255949 no 958 0.280932228163534 304 2875902
SGTC_2821 7996764 71.43 µM 0.579682423029886 0.271595845878157 no 959 0.281064399344147 260 2987135
SGTC_1896 st058441 89 µM 0.579134377149942 0.271784126742253 no 960 0.281249252806794 306 688759
SGTC_824 1304-0008 100 µM 0.577984585736457 0.27217934792832 no 961 0.281637263042008 312 768245
SGTC_516 3992-2719 87.3 µM 0.577866736481736 0.272219872733643 no 962 0.281677047197783 298 5350887 YDR037W KRS1
SGTC_3063 1327-0034 4 µM 0.576869321433997 0.272562973734027 no 963 0.282013868152893 323 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_488 nitrendipine 139 µM 0.574275226906804 0.273456320863575 no 964 0.2828907851667 311 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2520 obtusaquinone 4.71 µM 0.573880681329079 0.273592320273655 no 965 0.283024273406189 321 5967872
SGTC_157 1348-1695 65.819 µM 0.572604139464339 0.27403257199765 no 966 0.283456378150838 321 5380510
SGTC_2146 5545642 200 µM 0.568192979521924 0.275556575487639 no 967 0.284951968994392 316 825326
SGTC_191 3914-0123 66.505 µM 0.566909195636994 0.276000889362681 no 968 0.28538793813303 333 3144412
SGTC_2158 5657123 3.6195 µM 0.566873489086933 0.276013252323055 no 969 0.285400068508991 357 2858827
SGTC_2723 salbutamol 83.58 µM 0.566027462520592 0.276306258301794 no 970 0.285687555938887 319 9884233 β2-adrenoceptor agonist
SGTC_947 3447-0010 211 µM 0.56501551885866 0.276656926967758 no 971 0.286031604336367 328 748350
SGTC_3113 9123498 49.47 µM 0.564833295423523 0.276720095989025 no 972 0.286093578976587 334 8897275
SGTC_97 0535-0701 19.132 µM 0.56365811764266 0.277127649204241 no 973 0.286493413006945 314 2832013 YGL099W LSG1
SGTC_244 nsc-207895 1.295 µM 0.562881715145315 0.277397067648405 no 974 0.286757715966207 300 42640
SGTC_2867 9039098 71.43 µM 0.562622126563025 0.27748717570883 no 975 0.286846110895282 330 6463460
SGTC_1214 0358-0031 63.7 µM 0.56147224762461 0.277886492183306 no 976 0.287237822103173 349 4301366
SGTC_711 k292-0785 179 µM 0.561264059900637 0.27795881915319 no 977 0.287308769205045 303 4146315
SGTC_1806 st050005 60.3 µM 0.561028783612776 0.278040568078665 no 978 0.287388957642129 297 5194765
SGTC_1223 0764-0573 147 µM 0.560096284000563 0.278364689036915 no 979 0.287706882481434 308 1609797
SGTC_570 0987-0065 62.6 µM 0.559521681335254 0.278564502776618 no 980 0.287902869258674 320 3104428
SGTC_749 1000-0129 128 µM 0.55806712036495 0.279070627407246 no 981 0.288399275789889 324 708470
SGTC_523 1934-0222 13.7 µM 0.557877414393231 0.279136669870917 no 982 0.288464047588139 359 1361595
SGTC_1064 honokiol 6.76 µM 0.557392036212729 0.279305679476149 no 983 0.288629802714573 321 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_70 0141-0289 43.283 µM 0.557092897510472 0.279409864899867 no 984 0.288731979983324 309 352408
SGTC_1715 st032160 10.2275 µM 0.555363760451652 0.280012466474633 no 985 0.289322937515286 304 5289825
SGTC_145 3737-0113 38.366 µM 0.555271517001124 0.28004463086692 no 986 0.289354479008062 341 6849351
SGTC_289 k017-0060 526 µM 0.553236334839842 0.280754734329572 no 987 0.290050794776718 319 5512909
SGTC_2053 5265679 138 µM 0.553060656773306 0.280816071663074 no 988 0.290110937952903 327 764595
SGTC_2822 7994718 71.43 µM 0.552577823250509 0.280984684531728 no 989 0.290276265530566 348 1018011
SGTC_2265 7929201 200 µM 0.552525323373717 0.281003021242253 no 990 0.290294244732988 353 1265108
SGTC_2706 st078239 82.5 µM 0.550729762519129 0.281630507290973 no 991 0.290909469457146 322 15434492
SGTC_951 1171-0579 82.7 µM 0.549563301268207 0.282038506641685 no 992 0.291309467916967 321 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1888 azatryptophan 97.5 µM 0.548697043969855 0.282341686130661 no 993 0.291606687572811 294 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2173 5763948 167 µM 0.548508886105269 0.282407559809222 no 994 0.291671264693222 319 2867177
SGTC_2349 9023730 187.07 µM 0.547548385670309 0.282743944157545 no 995 0.292001019108763 327 4126287
SGTC_2223 6903751 107.57 µM 0.545636292002465 0.28341416588842 no 996 0.292657986148503 321 5598863
SGTC_1327 1436-0082 2.18 µM 0.544716358668819 0.283736889480292 no 997 0.292974306045297 324 15992205
SGTC_163 TUB2.036 7.546 µM 0.544199542647241 0.283918271878718 no 998 0.293152083263351 318 15992207 YJR013W GPI14
SGTC_1482 3346-2049 8.48 µM 0.543286334568065 0.284238908121571 no 999 0.29346633582919 295 3826804
SGTC_1925 st057770 10.1 µM 0.541911978880798 0.284721783834254 no 1000 0.293939572108894 299 5989122
SGTC_1142 3253-1408 9.78 µM 0.541549905535396 0.284849062342184 no 1001 0.294064304685573 331 256655
SGTC_2245 6637752 200 µM 0.541503446789212 0.284865395804409 no 1002 0.294080311277554 346 681890
SGTC_1751 st044839 27.194 µM 0.541046442021348 0.285026088395742 no 1003 0.294237786165151 298 5291326
SGTC_3273 9137859 49.47 µM 0.540218995080833 0.285317146255236 no 1004 0.294523007235038 359 2377234
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.539506647872326 0.285567830665338 no 1005 0.294768655565885 311 94937 An inhibitor of serotonin biosynthesis.
SGTC_3097 9117246 49.47 µM 0.538812744071696 0.285812125345783 no 1006 0.295008034596717 305 16423892
SGTC_1539 benzyladenosine 56 µM 0.534780742237872 0.287233588501982 no 1007 0.296400740570555 287 92208 A nucleotide analog.
SGTC_816 0325-0417 81.3 µM 0.534511169253103 0.287328744387107 no 1008 0.296493961986936 329 68101
SGTC_1968 st069590 43.6 µM 0.534456569277768 0.287348019310328 no 1009 0.296512844917977 322 6384066
SGTC_2467 5474540 200 µM 0.534180214574627 0.287445587632347 no 1010 0.296608428262983 307 5413519
SGTC_1271 0832-2808 169 µM 0.534156046321278 0.287454121092347 no 1011 0.296616788055413 337 3663794
SGTC_371 0195-0006 7.36 µM 0.532055234116313 0.28819634486652 no 1012 0.297343870472093 313 3928593
SGTC_3062 9077494 49.47 µM 0.531517470730497 0.288386483646193 no 1013 0.29753011896323 288 16459633
SGTC_2134 5324836 1.464 µM 0.530220692147528 0.288845233026374 no 1014 0.297979463025804 335 699272
SGTC_232 clozapine 119 µM 0.52827075312337 0.289535690788604 no 1015 0.298655713963443 331 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1076 itraconazole 331 nM 0.526343404434931 0.290218910147437 no 1016 0.29932481533677 321 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2447 5741742 33.78 µM 0.526230768041498 0.290258861592321 no 1017 0.299363939383789 320 1776504
SGTC_1402 3909-7673 35.9 µM 0.525805685730524 0.290409658908575 no 1018 0.299511611841394 321 5328014
SGTC_838 0109-0203 71.4 µM 0.525485301425585 0.29052333899717 no 1019 0.299622934308578 304 759422
SGTC_1353 1498-1206 8.11 µM 0.52502591512817 0.290686376677587 no 1020 0.299782587865129 315 6756808
SGTC_1358 1509-0022 2.48 µM 0.524873568335279 0.290740454493827 no 1021 0.299835542457823 336 3258434
SGTC_602 3130-1533 38.1 µM 0.524620337526185 0.290830353036839 no 1022 0.299923572940126 347 720941
SGTC_441 propafenone 146 µM 0.524590156077922 0.290841068508988 no 1023 0.299934065679964 341 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1187 1391-0724 117 µM 0.524132933300097 0.291003421194143 no 1024 0.300093041910355 334 6997986
SGTC_2689 tacrolimus 100 µM 0.522535018459503 0.29157114816111 no 1025 0.300648935559841 320 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1889 st059080 5.18 µM 0.52201349195494 0.291756554277857 no 1026 0.300830468360377 313 176925 Isolated from Daphnopsis sellowiana.
SGTC_2418 pentamidine 31.67 µM 0.521565100983037 0.291916004138228 no 1027 0.300986583683155 318 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1578 josamycin 24.2 µM 0.521147156626367 0.292064663578209 no 1028 0.301132131352981 317 5282165 A P450 substrate.
SGTC_106 0092-0003 11.579 µM 0.520685211381049 0.292229014767602 no 1029 0.301293039066449 332 1072148
SGTC_3279 9140807 49.47 µM 0.52059732102438 0.292260289328758 no 1030 0.30132365797955 323 45595718
SGTC_2008 4012253 172 µM 0.518432101789453 0.29303124363058 no 1031 0.302078410912862 327 603940
SGTC_171 k064-0041 9.68 µM 0.517369381216194 0.293409983881952 no 1032 0.302449164746412 320 53325
SGTC_2327 6189656 200 µM 0.514621835442073 0.294390224262922 no 1033 0.303408651824975 359 5349088
SGTC_2469 5655019 90.81 µM 0.514435884270333 0.29445662055166 no 1034 0.303473638068774 345 2788239
SGTC_270 tamoxifen 5.46 µM 0.514188854669021 0.294544836378621 no 1035 0.303559979626441 348 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2642 cholecalciferol 100 µM 0.512222926486307 0.295247316021488 no 1036 0.304247499664583 332 9821465 A vitamin D precursor, similar to steriods.
SGTC_1284 0929-0043 16 µM 0.511044910559586 0.29566862232702 no 1037 0.304659804791714 332 1239883
SGTC_1283 0922-0125 16.4 µM 0.509918660350964 0.296071673279598 no 1038 0.305054224106944 336 3360884
SGTC_1004 4084-0029 199 µM 0.509836321481697 0.296101149764249 no 1039 0.305083068546051 352 716894 YLR208W SEC13
SGTC_412 gemfibrozil 100 µM 0.509284177638494 0.296298846474868 no 1040 0.305276523411404 327 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.509264285876864 0.296305969907506 no 1041 0.305283493911714 333 260807
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.508149834289409 0.296705191208228 no 1042 0.305674134413794 328 6708514
SGTC_1487 3970-0795 2.82 µM 0.505192973444353 0.297765596159165 no 1043 0.306711652515644 324 3765103
SGTC_2890 9046729 58.44 µM 0.504738319715012 0.29792879969205 no 1044 0.30687132143272 325 903329
SGTC_1343 1487-0095 224 µM 0.50422283666181 0.298113887969532 no 1045 0.307052397202291 368 4560101 YGL055W OLE1
SGTC_3182 9108849 49.47 µM 0.503999662177945 0.298194036783863 no 1046 0.30713080718845 313 17133045
SGTC_2087 5276107 200 µM 0.503234670613119 0.298468843206912 no 1047 0.307399645769986 330 144405
SGTC_483 fpl-64176 144 µM 0.501864358176867 0.298961385708125 no 1048 0.307881469070111 355 3423
SGTC_2407 paclitaxel 400 µM 0.499979436273999 0.299639500925238 no 1049 0.30854477853812 386 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1301 naphtanilide LB 4.81 µM 0.499711772559208 0.299735851492906 no 1050 0.30863902092502 333 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_743 1275-0778 158 µM 0.498780305066782 0.300071259991373 no 1051 0.308967081879306 353 2849257 YMR203W TOM40
SGTC_2484 5809818 12.04 µM 0.497449368158149 0.300550806248065 no 1052 0.309436099637587 319 2870548
SGTC_2962 9082311 13.18 µM 0.497200174396253 0.300640631022928 no 1053 0.309523949237012 352 16459453
SGTC_1689 st020265 53.493 µM 0.495017324555029 0.301427981944291 no 1054 0.310293945714497 362 5758320 YPR016C TIF6
SGTC_2566 crystal violet carbinol 226 nM 0.493779256293178 0.301874963535836 no 1055 0.310731042293076 357 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2836 9010338 19.48 µM 0.493075520228436 0.302129167085579 no 1056 0.310979613545687 316 2994051
SGTC_2874 9043904 71.43 µM 0.492419895147405 0.302366078416003 no 1057 0.311211268825606 339 4463428
SGTC_1504 k297-0033 30 µM 0.492250473147543 0.302427312913404 no 1058 0.311271143711034 310 4388117
SGTC_2598 perillyl alcohol 100 µM 0.491638848197701 0.302648419877126 no 1059 0.311487337666771 334 10819 An apoptosis inducer.
SGTC_2676 harmalol 100 µM 0.491155375881037 0.302823249951324 no 1060 0.311658278921123 329 5459187 A monoamine oxidase inhibitor
SGTC_3175 9106517 49.47 µM 0.489056967659877 0.303582586020606 no 1061 0.312400682976485 360 41468073
SGTC_1880 MG-132 525 µM 0.488194145099287 0.303895055954724 no 1062 0.312706165642809 354 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_85 0868-0259 160.055 µM 0.487292437232962 0.30422176133538 no 1063 0.313025553199389 351 83173
SGTC_2277 7947813 106.88 µM 0.486737706318525 0.304422828268638 no 1064 0.313222110260064 365 1246798
SGTC_1953 st076800 12.1 µM 0.48624336479565 0.304602056378657 no 1065 0.313397314356305 336 297591
SGTC_129 0088-0017 176.636 µM 0.486203827903275 0.304616392873017 no 1066 0.313411328807061 343 182446
SGTC_356 1634-0012 32.5 µM 0.486044561040374 0.304674147757385 no 1067 0.313467786088875 374 735457
SGTC_1218 1348-1416 30.7 µM 0.485635810904693 0.304822394949906 no 1068 0.313612700771344 323 6787668
SGTC_1554 st069299 38.7 µM 0.484971955939995 0.305063232906181 no 1069 0.313848119375095 304 24207999
SGTC_3044 9093193 49.47 µM 0.483424089572465 0.305625106599719 no 1070 0.314397323537165 348 25236277
SGTC_819 1013-0258 27.7 µM 0.482458889048622 0.305975705214641 no 1071 0.314739998056169 337 5753198
SGTC_780 0109-0199 192 µM 0.482078562006036 0.306113903748285 no 1072 0.314875069171683 367 610414
SGTC_2507 purpurin 79.67 µM 0.481438297380255 0.306346617515218 no 1073 0.315102511665059 337 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_804 1595-0054 20.9 µM 0.481319578494143 0.306389776262399 no 1074 0.315144692122598 350 761523 Stimulates phospholipase C.
SGTC_3220 9131269 49.47 µM 0.477621414137053 0.307735539695594 no 1075 0.316459843304657 346 17722206
SGTC_2533 agelasine 13.65 µM 0.476582246311037 0.308114160359256 no 1076 0.31682981402133 359 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2164 5685496 200 µM 0.475641477285668 0.308457105650393 no 1077 0.317164910282959 327 759046
SGTC_1315 1237-0019 3.69 µM 0.473413891837536 0.309269809628652 no 1078 0.317958960388166 337 825140
SGTC_1201 1889-3372 45.9 µM 0.472095417571251 0.309751277196689 no 1079 0.318429341582128 332 5392199
SGTC_1341 1486-1360 280 µM 0.471161828656287 0.310092393638096 no 1080 0.31876258755246 335 3976547
SGTC_2887 9044784 58.44 µM 0.4703920556256 0.310373777734423 no 1081 0.319037469490428 345 6465546
SGTC_1801 st050089 28.441 µM 0.469516590460554 0.310693931644207 no 1082 0.319350214524619 333 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.467529221197845 0.311421236174722 no 1083 0.320060645324414 371 61125 An anti-inflammatory.
SGTC_3334 9142812 21.919 µM 0.46690728127654 0.311648994921434 no 1084 0.320283107814961 358 45283678
SGTC_206 4546-0025 72.014 µM 0.465094883763249 0.312313118368755 no 1085 0.320931754841503 357 6620745 YIL048W NEO1
SGTC_762 1165-0429 115 µM 0.463448958453103 0.312916769647874 no 1086 0.321521296375323 370 5967793
SGTC_2300 7976697 71.57 µM 0.461161954230677 0.313756372899615 no 1087 0.322341207679076 330 2236109
SGTC_2889 9059656 51.95 µM 0.460797031073692 0.313890432638056 no 1088 0.322472115997484 354 3949838
SGTC_1385 3091-4834 14.1 µM 0.459547640011923 0.314349600285767 no 1089 0.322920474744854 350 4072814
SGTC_672 1441-0018 53.7 µM 0.459547294660276 0.314349727246802 no 1090 0.322920598713998 344 251141
SGTC_2565 isoliquiritigenin 100 µM 0.459499857022633 0.314367166873092 no 1091 0.322937627351148 312 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1513 0337-0559 19 µM 0.459412124019834 0.314399421484532 no 1092 0.322969121749698 339 775073
SGTC_207 4185-0010 4.486 µM 0.457894984723724 0.314957414301883 no 1093 0.32351394511847 353 3761753
SGTC_1321 1326-2144 215 µM 0.45668729124803 0.315401897390981 no 1094 0.323947913391279 375 3513030
SGTC_905 2-aminofluorene 215 µM 0.456061872019893 0.315632183626872 no 1095 0.324172743436994 339 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3196 9111891 49.47 µM 0.454311432850856 0.316277095025406 no 1096 0.324802344200931 365 18891510
SGTC_1241 0364-0022 50.8 µM 0.45390006417065 0.316428736134074 no 1097 0.324950378691399 367 4563895
SGTC_2516 gossypol 71.55 µM 0.452952040131032 0.316778319762809 no 1098 0.325291638368821 349 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2411 st077133 39.94 µM 0.451855823409711 0.317182753457423 no 1099 0.325686425596089 387 1403142 YNL221C POP1
SGTC_276 colchicine 750 µM 0.450286736309363 0.317762026043262 no 1100 0.32625185078779 371 2833 A microtubule depolymerizer.
SGTC_1375 2910-0797 186 µM 0.449348797885631 0.318108505610092 no 1101 0.326590030594405 372 742508
SGTC_2067 5224629 34.075 µM 0.449098296098844 0.31820106929205 no 1102 0.326680374776365 343 2835000
SGTC_2833 9001315 45.46 µM 0.447515017643562 0.318786373838987 no 1103 0.327251623610886 337 2989378
SGTC_139 0099-0334 718.624 µM 0.445519630700664 0.319524670330787 no 1104 0.327972138255195 358 97690
SGTC_923 1900-2434 73.3 µM 0.444242527671359 0.31999757653761 no 1105 0.328433624089464 375 5910570
SGTC_2194 5927483 104.545 µM 0.443869993091551 0.320135579788192 no 1106 0.328568290184725 311 760979
SGTC_3170 9103054 49.47 µM 0.443078043275243 0.320429035623391 no 1107 0.32885464305715 369 16432970
SGTC_2297 7971671 152.32 µM 0.442897375086416 0.32049599769389 no 1108 0.328919983066446 364 909016
SGTC_572 0960-0087 17.7 µM 0.44187056830448 0.320876679814607 no 1109 0.32929143471218 366 6796365
SGTC_620 0109-0052 432 µM 0.441448527145342 0.321033203561675 no 1110 0.32944415876636 357 493037
SGTC_1460 k062-0059 9.15 µM 0.441321609482934 0.321080280140775 no 1111 0.329490092033356 339 1373085
SGTC_680 0417-1641 114 µM 0.440495452635518 0.321386790319438 no 1112 0.329789152541386 351 2835990
SGTC_61 0978-8327 98.565 µM 0.440424809724544 0.321413005001109 no 1113 0.329814729622131 365 6150059 YHR072W ERG7
SGTC_1170 0310-0127 64.8 µM 0.439543303016674 0.321740195649285 no 1114 0.330133956181186 389 774975
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.437527970073698 0.322488750086241 no 1115 0.330864248047296 386 91467 include heat shock
SGTC_1062 mesoridazine 14.2 µM 0.437025761992797 0.322675397277833 no 1116 0.331046332474838 361 4078 A neuroleptic.
SGTC_2256 7954252 200 µM 0.43475077768106 0.323521461418497 no 1117 0.33187166835888 383 2972920
SGTC_898 1000-0849 28.3 µM 0.434360434697176 0.32366672144483 no 1118 0.332013362099564 384 6751807
SGTC_702 1488-0190 94 µM 0.43386123023266 0.323852531718818 no 1119 0.332194607354058 351 949357
SGTC_89 0302-0250 142.109 µM 0.432738636854429 0.324270535634118 no 1120 0.332602328637371 363 4203518 YLR208W SEC13
SGTC_1168 k815-0004 80.5 µM 0.432594618436866 0.324324177743561 no 1121 0.332654649879711 374 642433
SGTC_2795 7780010 54.55 µM 0.431167811727151 0.324855813019614 no 1122 0.333173178312054 350 953673
SGTC_2166 5933061 31.504 µM 0.430212759487362 0.325211869722014 no 1123 0.333520440616548 358 2877375
SGTC_1716 st033144 30.6155 µM 0.429374332751073 0.325524578431837 no 1124 0.333825414882613 395 674617
SGTC_591 4299-0174 154 µM 0.428963949910018 0.325677684053262 no 1125 0.333974729987054 392 5509088
SGTC_2010 4012422 159 µM 0.428825699284729 0.325729269217723 no 1126 0.334025037490715 382 952393
SGTC_1186 1319-0216 26 µM 0.42766786456635 0.326161420567955 no 1127 0.33444647465326 354 4565136
SGTC_2190 6049624 200 µM 0.427412525968296 0.326256754844171 no 1128 0.334539442774792 371 2265554
SGTC_754 3474-0146 171 µM 0.425428796730606 0.326997794545304 no 1129 0.335262058693347 335 24762078
SGTC_1778 st046819 58.9 µM 0.424787364496963 0.327237553465119 no 1130 0.33549584478377 412 671715
SGTC_1619 st003326 88.7 µM 0.424048784930452 0.327513713092838 no 1131 0.33576511756811 346 2849032
SGTC_1667 st014849 34.6 µM 0.423278094378165 0.327801979875607 no 1132 0.336046187364869 354 5348460
SGTC_530 4358-1714 28 µM 0.419986752990716 0.329034216784154 no 1133 0.337247565499725 377 1564641
SGTC_778 3456-2434 196 µM 0.419673078926401 0.329151749710322 no 1134 0.337362147109624 337 5539063
SGTC_613 3914-0030 117 µM 0.41943463835862 0.329241104123733 no 1135 0.337449256860877 373 1145395
SGTC_2114 5491910 81.25 µM 0.419066849070738 0.329378950451343 no 1136 0.337583638802481 408 2849228
SGTC_2263 7948595 193.29 µM 0.418606685561017 0.329551451022435 no 1137 0.337751801378006 384 2971371
SGTC_2079 5212404 121 µM 0.418528023581259 0.329580942512268 no 1138 0.337780550927193 352 758462
SGTC_522 1273-0010 11.6 µM 0.418336170405249 0.329652875428515 no 1139 0.337850673806855 380 5705015
SGTC_1114 scopoletin 1.73284 µM 0.416296855139899 0.330417879919704 no 1140 0.338596396766922 383 5280460 A coumarin with genotoxic properties.
SGTC_2224 6650123 117.647 µM 0.415292456269048 0.330794919058552 no 1141 0.338963911474051 384 2908370
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.413373319980909 0.33151581680214 no 1142 0.339666559422964 355 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_777 1315-0167 517 µM 0.412870027325782 0.331704975408015 no 1143 0.339850920925839 359 4221767
SGTC_936 3005-4620 401 µM 0.412845425761825 0.331714222813937 no 1144 0.339859933725324 401 777207
SGTC_2177 5811945 192 µM 0.412254468989716 0.331936386537104 no 1145 0.340076458634828 394 5343475
SGTC_1497 4476-2978 41.3 µM 0.411405829877593 0.332255526477372 no 1146 0.340387489896748 387 1528379
SGTC_2477 5967686 25.23 µM 0.410487574978564 0.332600983252759 no 1147 0.340724158091943 377 776118
SGTC_1306 1185-0270 9.02 µM 0.409138285548485 0.33310885752428 no 1148 0.341219090631494 393 1548076
SGTC_2099 5377090 177.372 µM 0.408556600981725 0.333327898862779 no 1149 0.341432542562203 373 2243829
SGTC_393 acivicin 6.25 µM 0.406896426936735 0.333953372747352 no 1150 0.342042030182937 370 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2084 5306078 60.6385 µM 0.40664228786203 0.334049160928855 no 1151 0.342135366797029 402 679340
SGTC_1901 st060216 58.6 µM 0.405721868918909 0.334396168735168 no 1152 0.342473485976821 359 688792
SGTC_1658 st012944 20 µM 0.405502143498965 0.334479028513306 no 1153 0.342554221574639 383 24207260
SGTC_1100 amiodarone 5.07 µM 0.404757829735407 0.334759773615209 no 1154 0.342827764611541 351 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.402530665048547 0.335600381381754 no 1155 0.343646762552029 345 6857784
SGTC_1139 k015-0024 46.9 µM 0.39954547178086 0.336728386047163 no 1156 0.344745662772488 375 2766652
SGTC_1044 1222-0021 1.78 µM 0.398892327202654 0.336975383941851 no 1157 0.34498627150507 362 4306703
SGTC_3123 9126162 49.47 µM 0.396787638978378 0.337771786004655 no 1158 0.34576203337817 341 25239884
SGTC_169 k015-0017 16.025 µM 0.396683578864239 0.337811180647216 no 1159 0.345800405478724 398 1840002
SGTC_2586 curcumin 80 µM 0.395111009881098 0.338406733333135 no 1160 0.346380481926939 358 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2732 terfenadine 20 µM 0.394759620435557 0.338539864500701 no 1161 0.346510148930192 405 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2416 tofa 880 nM 0.391368119105063 0.339825840207582 no 1162 0.347762577036813 344 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.391120303714615 0.339919879187757 no 1163 0.347854156726955 401 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2982 9019404 25.97 µM 0.390209899384128 0.340265437544773 no 1164 0.348190671027738 325 22333232
SGTC_2936 9038235 15.59 µM 0.387984355364399 0.341110742437274 no 1165 0.349013805575931 366 4749415
SGTC_355 1311-2252 105 µM 0.386388151398045 0.341717503499064 no 1166 0.349604611954715 375 5338538
SGTC_451 chloral hydrate 100 µM 0.386052891250147 0.341844997156666 no 1167 0.349728748869579 391 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2697 mebhydrolin 72.4 µM 0.385803464971179 0.341939861376723 no 1168 0.349821114466509 373 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_840 0245-0196 390 µM 0.385331414675348 0.342119423432506 no 1169 0.349995944781068 370 3827528
SGTC_1732 st034308 51.822 µM 0.384927484802106 0.342273101680248 no 1170 0.350145571012847 354 830119
SGTC_1268 0828-0275 2.46 µM 0.384026135487392 0.342616121160626 no 1171 0.350479538320978 381 745337
SGTC_1861 st057647 17.4 µM 0.383908908463185 0.342660742881295 no 1172 0.350522981696147 422 688668
SGTC_1809 st050081 57.6 µM 0.383156027689007 0.342947374463098 no 1173 0.35080203972543 400 5036894
SGTC_1394 3474-0001 65.7 µM 0.38233232575002 0.343261072157857 no 1174 0.351107440103337 370 5017666 YIL048W NEO1
SGTC_2431 5490079 200 µM 0.382272382302349 0.343283905170567 no 1175 0.351129668831211 391 5722345
SGTC_213 1246-0773 967 nM 0.380893628969603 0.34380924279905 no 1176 0.35164109006956 394 6251622
SGTC_969 1313-0238 134 µM 0.38006453792251 0.344125291436816 no 1177 0.351948754369269 390 5212874
SGTC_49 0717-0965 32.132 µM 0.375513035172169 0.345862254502513 no 1178 0.353639476943765 397 5889349 YGL099W LSG1
SGTC_3239 9133757 49.47 µM 0.373281580401972 0.346715020686163 no 1179 0.354469442026938 419 17036923
SGTC_3095 9117207 49.47 µM 0.372242245404505 0.347112475468742 no 1180 0.354856247560039 373 17015229
SGTC_13 0199-0087 65 µM 0.37180224415107 0.347280788197903 no 1181 0.35502004634608 379 4589825
SGTC_1117 retinoic acid 1.10837 µM 0.371749549772106 0.347300947285312 no 1182 0.355039664622393 385 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_995 3931-2021 34.6 µM 0.370918893792641 0.347618785218837 no 1183 0.35534897109782 381 730143
SGTC_317 4495-0002 170 µM 0.370543655109791 0.347762399765924 no 1184 0.355488727781086 379 15991618
SGTC_1942 st076330 65.2 µM 0.369119437894547 0.348307686987301 no 1185 0.356019350536289 400 24208414
SGTC_2072 5231554 129 µM 0.368157616943045 0.348676115003951 no 1186 0.356377855520815 401 789545
SGTC_977 1348-1378 135 µM 0.366695125936857 0.349236599475567 no 1187 0.356923221314156 395 X977
SGTC_2381 9035592 200 µM 0.365248272567572 0.349791414732941 no 1188 0.35746304368153 385 4749657
SGTC_2544 sphondin 68.51 µM 0.365230480647053 0.349798239282358 no 1189 0.357469683642042 367 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_670 4204-0025 119 µM 0.365084988231927 0.349854048466779 no 1190 0.357523983159269 421 719039
SGTC_3332 9141069 11.198 µM 0.364655573124967 0.350018785979945 no 1191 0.357684262851514 379 17332883
SGTC_1754 st042065 16.137 µM 0.364522617987561 0.350069797592744 no 1192 0.357733893602463 395 1126236 YIL048W NEO1
SGTC_3274 9138298 49.47 µM 0.361689144953268 0.351157573360338 no 1193 0.358792169863488 382 17015756
SGTC_1703 st026983 48.3 µM 0.360957648811014 0.351438594735714 no 1194 0.359065553506798 390 1104023
SGTC_496 calpeptin 138 µM 0.35999148822172 0.351809892428907 no 1195 0.359426749431054 371 73364 A calpain inhibitor.
SGTC_2160 5660466 132.927 µM 0.359967438359105 0.351819136650197 no 1196 0.359435741996226 402 2859134
SGTC_1091 telmisartan 47.6 µM 0.358665176548939 0.352319827199495 no 1197 0.35992279121659 394 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2841 9004761 38.96 µM 0.358627763974448 0.352334215285676 no 1198 0.359936786980216 356 2991039
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.358252938322177 0.352478376978869 no 1199 0.360077016808837 392 364106
SGTC_1429 4049-0205 9.46 µM 0.356599366904293 0.353114609811068 no 1200 0.360695875749171 367 22774478
SGTC_1374 2889-5571 141 µM 0.356225127261126 0.353258660393442 no 1201 0.360835987870134 370 2853281
SGTC_2011 4012611 177 µM 0.354480297099817 0.353930549556285 no 1202 0.361489483654424 399 2049887
SGTC_462 ag-879 158 µM 0.351443026027681 0.355101209135785 no 1203 0.362628004142082 418 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2345 9052315 157.45 µM 0.351367699119043 0.355130259932419 no 1204 0.362656255909683 383 6469265
SGTC_2016 5121758 140 µM 0.351316268035968 0.355150095478607 no 1205 0.362675545847257 399 2795203
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.348143751614183 0.356374404274469 no 1206 0.363866114027685 366 115019
SGTC_2435 5706476 10.6 µM 0.347625701811299 0.356574466431685 no 1207 0.364060650749749 379 5725375
SGTC_32 0928-0142 34.1 µM 0.347453517833104 0.356640969742042 no 1208 0.364125316591982 411 2244242
SGTC_23 0213-0011 39.996 µM 0.346796478527519 0.356894780706826 no 1209 0.364372111438682 384 627608
SGTC_1420 4'-methoxyflavone 42 µM 0.346492701559713 0.35701214964059 no 1210 0.364486234117655 407 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_887 0885-0007 9.62 µM 0.345441471884216 0.357418412889299 no 1211 0.364881251863926 414 5719458
SGTC_164 4100-3994 89.624 µM 0.345161398268547 0.357526678767886 no 1212 0.364986518592905 436 4615967
SGTC_789 1309-1135 70.6 µM 0.343758480920404 0.358069166031445 no 1213 0.365513963404385 386 3092424
SGTC_679 0422-0091 41.4 µM 0.341492923135043 0.358945828468718 no 1214 0.366366265778142 415 627384 YHR062C RPP1
SGTC_3055 9094636 49.47 µM 0.341410758954351 0.358977636071676 no 1215 0.366397188344981 393 25236176
SGTC_2704 st078022 71.1 µM 0.340676724602851 0.359261840646765 no 1216 0.366673481334248 412 54697681
SGTC_2091 4-phenylthiadiazole 200 µM 0.340123592316053 0.359476054747888 no 1217 0.366881727841942 380 270010
SGTC_2612 dictamnine 15.46 µM 0.339525591044969 0.359707695156375 no 1218 0.367106910966155 411 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_65 0798-0905 34.986 µM 0.338217729092763 0.360214485129127 no 1219 0.367599558209915 427 3602145
SGTC_1213 1315-0166 115 µM 0.337810215162458 0.360372444997552 no 1220 0.367753105692943 368 768401
SGTC_366 0181-0206 4.31 µM 0.337263797458365 0.360584283917357 no 1221 0.367959024005576 390 274874
SGTC_723 4182-0001 115 µM 0.334579021037267 0.361625756821676 no 1222 0.368971336243363 412 744821 YLR208W SEC13
SGTC_2971 9092186 9.93 µM 0.334323631562603 0.361724880534474 no 1223 0.369067679976602 340 25236400
SGTC_19 0279-0214 38.434 µM 0.331298238080325 0.362899823705815 no 1224 0.370209611021378 397 3566274 YBR002C RER2
SGTC_1874 staurosporine 7.6 µM 0.331068910293934 0.362988938355176 no 1225 0.37029621732012 413 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_380 3970-0968 6 µM 0.329115473058326 0.363748326250049 no 1226 0.371034204669284 404 2891601
SGTC_154 3389-1638 511.116 µM 0.328175437898041 0.364113950761392 no 1227 0.371389509036781 427 5238686
SGTC_1116 jasmonic acid 1.58368 µM 0.328106037114823 0.364140948944379 no 1228 0.371415744746465 430 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_733 4069-0007 56.1 µM 0.32810087355591 0.364142957690856 no 1229 0.371417696760312 392 5717425 YNL287W SEC21
SGTC_2965 9082772 38.63 µM 0.327243413234972 0.364476581758284 no 1230 0.371741893913323 364 16459634
SGTC_1022 4477-0945 21.3 µM 0.326832087716474 0.364636658385419 no 1231 0.371897444272468 388 4648966
SGTC_837 0091-0265 12.5 µM 0.325619458279642 0.36510871783267 no 1232 0.372356144158756 406 759367
SGTC_2963 9082507 9 µM 0.324454658798841 0.365562350329757 no 1233 0.372796922051157 409 16459611
SGTC_134 0269-0018 6.916 µM 0.323939828782478 0.365762911451431 no 1234 0.372991794709545 404 4378915
SGTC_1066 ketoconazole 628 nM 0.322909839058576 0.366164272233756 no 1235 0.37338176233343 424 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1899 st063254 59.6 µM 0.321710400097828 0.366631847655746 no 1236 0.373836049125967 383 3093813
SGTC_755 1995-0008 37.3 µM 0.321148972467581 0.366850776185312 no 1237 0.374048749783339 387 689533
SGTC_136 0097-0015 404.482 µM 0.321023714279908 0.366899626489089 no 1238 0.374096209930642 375 4861337
SGTC_280 3448-3607 3.04 µM 0.320467539828967 0.367116558818834 no 1239 0.374306966671681 411 626179
SGTC_2012 4023501 200 µM 0.319375585805126 0.367542591959561 no 1240 0.374720860948715 423 3477460
SGTC_1325 1431-0015 227 µM 0.31920123239543 0.367610632215249 no 1241 0.374786961246446 382 1103340
SGTC_2854 9024559 71.43 µM 0.318497665832385 0.367885236574822 no 1242 0.375053732470332 400 3163529
SGTC_2489 cantharidin 73.42 µM 0.318277130614449 0.367971326110167 no 1243 0.375137365087204 411 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_118 0083-0097 135.343 µM 0.318270812049179 0.367973792763385 no 1244 0.375139761335908 411 5207356
SGTC_3128 9127691 49.47 µM 0.31817149127604 0.368012566506137 no 1245 0.375177428316363 422 41316314
SGTC_1255 0566-0045 221 µM 0.317714412112413 0.36819102253781 no 1246 0.375350788982402 418 2788469
SGTC_94 0334-0113 514.748 µM 0.317559888073114 0.368251359325318 no 1247 0.375409402448363 427 6795178
SGTC_1415 3966-0071 78.1 µM 0.316628827164305 0.368614978118309 no 1248 0.375762629733373 419 2893185
SGTC_1990 st072050 59.8 µM 0.316288238416788 0.368748021889463 no 1249 0.375891868835216 384 17233948
SGTC_309 k408-0051 1.48 µM 0.316285362343726 0.368749145433416 no 1250 0.375892960243253 413 3640463
SGTC_314 1671-0008 2.74 µM 0.31627584749874 0.368752862435494 no 1251 0.375896570929916 407 3913060
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.315152611222461 0.369191744166921 no 1252 0.376322892112603 432 442882
SGTC_2358 9037157 4 µM 0.312896540204076 0.370073772875479 no 1253 0.377179633107954 389 2388925
SGTC_1722 st034304 3.6505 µM 0.311046886772619 0.370797419791652 no 1254 0.377882488893493 413 4036148 YLR033W RSC58
SGTC_2144 5628481 200 µM 0.309716953168057 0.371318017502326 no 1255 0.37838810476343 401 2818399
SGTC_2445 5742597 35.57 µM 0.309364924006648 0.371455857507965 no 1256 0.378521974563037 387 1774255
SGTC_1345 1488-0192 31.4 µM 0.308101208544675 0.371950811724854 no 1257 0.37900266082423 425 658348
SGTC_3033 9090887 49.47 µM 0.307832226344352 0.372056190223851 no 1258 0.379104999219426 392 19325384
SGTC_3333 9141820 12.094 µM 0.30766503881886 0.372121693702107 no 1259 0.379168612543402 433 1939433
SGTC_1030 k029-0042 36.7 µM 0.307371469929056 0.372236721902993 no 1260 0.379280320736791 395 6080581
SGTC_1149 3909-7961 23.3 µM 0.305498951093977 0.372970693117189 no 1261 0.379993084358737 397 735261
SGTC_2519 cryptotanshinone 88.04 µM 0.303779034062113 0.373645255569044 no 1262 0.380648120380011 390 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1787 fluconazole 80 µM 0.303632838857428 0.373702612150355 no 1263 0.380703815112055 403 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3256 9138902 49.47 µM 0.302962103583005 0.37396579671895 no 1264 0.38095937104643 423 17228773
SGTC_229 benomyl 22.8748 µM 0.30240254973562 0.374185400644552 no 1265 0.381172605637165 408 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_926 2268-1401 59.4 µM 0.301605942484663 0.374498109581572 no 1266 0.381476238697361 445 2931578
SGTC_286 k060-0067 22.9 µM 0.299013973476271 0.375516159902159 no 1267 0.382464691878001 393 5985051
SGTC_2050 5263056 171 µM 0.298960045445728 0.375537350505701 no 1268 0.382485265612557 407 763468 YGL055W OLE1
SGTC_3212 9128307 49.47 µM 0.298791669912544 0.375603514788548 no 1269 0.382549503608833 380 27243542
SGTC_293 4049-0273 38.5 µM 0.298515813170825 0.375711922431682 no 1270 0.382654754413146 414 1380311
SGTC_1944 st076371 56.9 µM 0.296929492055745 0.376335513511079 no 1271 0.383260169812258 431 24208455
SGTC_2188 6126565 140.678 µM 0.296139205073269 0.376646300054734 no 1272 0.38356188735222 413 874518
SGTC_16 erodoxin 22.806 µM 0.295875951292801 0.376749844430543 no 1273 0.383662408660997 416 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2313 7726885 200 µM 0.294342057749743 0.377353339712083 no 1274 0.384248268920587 389 726423
SGTC_3252 9135871 49.47 µM 0.292176535673946 0.378205852829815 no 1275 0.38507582554696 422 17682838
SGTC_895 0964-0006 13.7 µM 0.291792329248505 0.378357167597628 no 1276 0.385222705261175 432 6738897
SGTC_2640 pentamidine 10.38 µM 0.291484118414724 0.378478565964386 no 1277 0.385340544240482 417 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1695 st026914 34.495 µM 0.290298760380432 0.378945567551429 no 1278 0.385793843554675 404 3289191
SGTC_227 fluconazole 33.516 µM 0.288680235360306 0.379583511515482 no 1279 0.386413044478467 432 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.287663936183968 0.379984255021262 no 1280 0.386801999185126 433 6710655
SGTC_1326 1431-2094 10.8 µM 0.285958973458523 0.380656839229246 no 1281 0.387454772208233 445 616278
SGTC_745 0469-0705 296 µM 0.285622925855201 0.380789447995719 no 1282 0.387583471171031 432 3486736
SGTC_722 3534-0461 190 µM 0.284862116984009 0.381089724822536 no 1283 0.387874890134321 387 658262
SGTC_618 k072-0232 33.2 µM 0.283530172160655 0.381615590513972 no 1284 0.38838522805756 435 5872756 YGL099W LSG1
SGTC_2404 5161160 200 µM 0.281894852654104 0.38226153054364 no 1285 0.389012068269666 448 2831543
SGTC_1909 st060837 51.5 µM 0.281108489379763 0.382572255488042 no 1286 0.389313595013379 424 678937
SGTC_2916 7875993 68.79 µM 0.281011482105798 0.38261059235324 no 1287 0.389350796550231 431 1299250
SGTC_3054 9094397 49.47 µM 0.280936748402367 0.382640127581892 no 1288 0.389379457037216 414 2598354
SGTC_3253 9135987 49.47 µM 0.279461861953598 0.383223151419851 no 1289 0.3899452011282 416 4182430
SGTC_121 0557-0495 61.343 µM 0.277914055015712 0.383835285327335 no 1290 0.390539167209099 452 3104427
SGTC_1489 4065-0444 182 µM 0.276841809518385 0.384259512094291 no 1291 0.390950787988869 450 2877968
SGTC_3294 9122953 26.2835 µM 0.276615578306237 0.384349036695898 no 1292 0.391037650767704 441 16459826
SGTC_550 4123-0385 25.7 µM 0.273978108906453 0.385393194638688 no 1293 0.392050722383622 424 5731123
SGTC_1421 4029-0249 71.4 µM 0.273582317623875 0.385549957895211 no 1294 0.392202812112202 427 2894095
SGTC_1614 st002383 48.6 µM 0.272718490334398 0.385892163685342 no 1295 0.392534810037173 427 1947235
SGTC_1077 5-fluorocytosine 377 nM 0.272456321133575 0.385996039779443 no 1296 0.392635585975216 449 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2371 9071574 200 µM 0.271457061027933 0.386392039275382 no 1297 0.39301976026072 439 45596039
SGTC_413 propylparaben 100 µM 0.270192685507063 0.386893271660361 no 1298 0.393506009810467 401 7175 A pharmaceutical preservative.
SGTC_2055 5235184 200 µM 0.267286157152587 0.388046211713937 no 1299 0.394624422082834 455 2836034
SGTC_93 0109-0045 59.227 µM 0.264277834507968 0.389240570769063 no 1300 0.395782919394322 439 88733
SGTC_2999 9069765 71.4286 µM 0.262991266751076 0.38975168203824 no 1301 0.396278655188825 442 2097066
SGTC_3296 9122258 64.045 µM 0.262350044026332 0.390006490112937 no 1302 0.396525791580024 434 4730474
SGTC_1573 oleylamine 1.06 µM 0.26072400969449 0.390652852762808 no 1303 0.397152674604963 455 5356789 An amine of the fatty acid oleic acid.
SGTC_3020 9089140 49.47 µM 0.260513194343245 0.390736675853201 no 1304 0.397233969487974 402 17217859
SGTC_2320 7373003 200 µM 0.259000140885936 0.391338435545767 no 1305 0.397817565894858 401 5415828
SGTC_798 1287-0182 476 µM 0.258043070949366 0.391719208284808 no 1306 0.398186833348667 452 1649755
SGTC_2493 resveratrol 26.09 µM 0.257584630022454 0.39190163696341 no 1307 0.398363746494632 416 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3059 1327-0034 3 µM 0.256722653511526 0.392244710014405 no 1308 0.398696441263934 400 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2521 angolensin 13.4 µM 0.255556702670385 0.392708900360049 no 1309 0.399146577305779 429 821428 A flavenoid.
SGTC_3250 9135583 49.47 µM 0.254096212159974 0.39329056864139 no 1310 0.399710614810097 406 7699353
SGTC_2355 9061122 103.12 µM 0.253646181242114 0.393469850145812 no 1311 0.399884457785821 439 5302957
SGTC_1681 tripelennamine 100 µM 0.251976046643781 0.394135388828997 no 1312 0.400529789279397 400 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.250063047620806 0.39489808742513 no 1313 0.401269296004411 433 5024745
SGTC_769 0302-0231 76 µM 0.250009040838725 0.394919625392612 no 1314 0.401290178516943 445 571869 YER009W NTF2
SGTC_304 1310-0298 97 µM 0.249974023699655 0.39493359043999 no 1315 0.401303718556825 460 1550234
SGTC_2749 bexarotene 57.39 µM 0.249791097338079 0.395006544776026 no 1316 0.401374452424696 416 82146 An retinoic acid receptor inhibitor.
SGTC_801 0866-0028 10.1 µM 0.249175351399454 0.395252142410159 no 1317 0.401612572473567 436 6849771
SGTC_1705 st027868 56.3335 µM 0.248313715559647 0.395595886014076 no 1318 0.401945843895242 462 292948
SGTC_2860 9025725 38.96 µM 0.247860220703944 0.395776837266558 no 1319 0.402121279458195 453 40546248
SGTC_1239 0337-0584 35.4 µM 0.246996745312484 0.396121438985575 no 1320 0.402455371459852 441 914301 YML130C ERO1
SGTC_984 1492-0255 2.91 µM 0.244278822842121 0.397206655033809 no 1321 0.40350744183425 451 1585198
SGTC_3238 9133470 49.47 µM 0.243862274069871 0.397373045816989 no 1322 0.40366874406239 449 3534688
SGTC_2388 9080168 200 µM 0.243113512533301 0.397672186231368 no 1323 0.403958731854178 447 15943073
SGTC_2057 5236571 38.335 µM 0.243073870968911 0.397688025254255 no 1324 0.403974086105102 435 54684039 YBR257W POP4
SGTC_2178 5812956 200 µM 0.242877272477402 0.397766579843071 no 1325 0.4040502362084 427 5403383
SGTC_1506 4226-2149 212 µM 0.242175083139511 0.398047186493489 no 1326 0.40432225062137 437 991114
SGTC_2424 5537928 59.2 µM 0.241635952741161 0.398262667854631 no 1327 0.404531130591977 456 5382802
SGTC_634 1611-4317 11.2 µM 0.241155342642474 0.398454785797079 no 1328 0.40471736047934 443 2843522
SGTC_2019 4016004 108 µM 0.238907128721582 0.399353807655744 no 1329 0.405588798843236 414 45595336
SGTC_1397 3532-0190 20.1 µM 0.237614031138566 0.399871137226445 no 1330 0.406090233445814 417 5322280
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.237537351103448 0.399901820139583 no 1331 0.406119973112644 439 279621
SGTC_1714 st033236 13.627 µM 0.237393701845999 0.399959301923708 no 1332 0.406175687652084 419 2916566
SGTC_946 3434-1334 87.4 µM 0.237362265557174 0.399971881560636 no 1333 0.406187880508418 421 4047976
SGTC_1813 st051246 8.6015 µM 0.237307843400276 0.399993659534901 no 1334 0.406208988862063 449 5291959
SGTC_512 prima-1 270 µM 0.237126778780456 0.40006611793569 no 1335 0.406279219132598 425 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1178 0988-0033 191 µM 0.235813085393892 0.400591934362731 no 1336 0.406788856899698 433 5392207
SGTC_1132 3456-3614 2.5 µM 0.23518493067235 0.400843422120903 no 1337 0.407032600795788 417 3125502
SGTC_1474 0330-0125 5.35 µM 0.23444476095638 0.401139808895494 no 1338 0.407319856261747 450 X1474
SGTC_2312 7706453 155.7 µM 0.2329901928016 0.401722428468561 no 1339 0.407884510620014 438 976098
SGTC_202 3594-0513 34.79 µM 0.23241729392953 0.401951960128922 no 1340 0.40810695901685 428 708429
SGTC_2785 7756463 72.73 µM 0.230536282766855 0.402705823778135 no 1341 0.408837536532876 455 2201551
SGTC_2628 lathosterol 100 µM 0.230502125350325 0.402719516596061 no 1342 0.408850806079106 417 6710616
SGTC_427 1354-0053 47.3 µM 0.228495032669757 0.403524316700571 no 1343 0.409630708675361 427 6813657
SGTC_1408 3909-7976 48.8 µM 0.228136586354784 0.403668088915148 no 1344 0.409770029074037 441 24152374
SGTC_2695 st077686 51.995 µM 0.227662677361404 0.403858192996172 no 1345 0.409954244827343 419 2876092
SGTC_1232 0279-0259 161 µM 0.227499066624421 0.403923829161957 no 1346 0.410017847468085 446 1560000
SGTC_547 1120-0019 610 nM 0.226846731225653 0.404185555212241 no 1347 0.41027146225577 442 3676939
SGTC_2401 5128683 200 µM 0.22620322787434 0.404443779748651 no 1348 0.410521680096713 447 708373
SGTC_3311 9131146 2.8755 µM 0.2246335059303 0.405073851000297 no 1349 0.411132198492988 429 4900406 YPR165W RHO1
SGTC_2850 9015429 58.44 µM 0.224483716273343 0.40513398801423 no 1350 0.411190468074778 461 6457570
SGTC_216 k038-0035 28.382 µM 0.224325711955447 0.405197425448446 no 1351 0.411251935360208 440 4444231 YPR107C YTH1
SGTC_826 1683-5028 118 µM 0.222937751302198 0.405754787102634 no 1352 0.411791977194629 432 722377
SGTC_2794 7785382 27.27 µM 0.222503407314291 0.40592924539832 no 1353 0.411961010547569 471 2205081
SGTC_1073 triclabendazole 3.09 µM 0.222494240452506 0.405932927554905 no 1354 0.411964578185044 419 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2636 apigenin dimethyl ether 100 µM 0.219667818460512 0.407068643612703 no 1355 0.413064934816158 449 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_347 4534-1311 26.2 µM 0.219272109526294 0.407227710431114 no 1356 0.413219043309169 423 2862016
SGTC_375 3970-0961 9.27 µM 0.218132679607399 0.407685823100028 no 1357 0.413662867888053 416 2898222
SGTC_1393 3470-5649 58.2 µM 0.216865319150485 0.408195519088093 no 1358 0.41415665285454 473 4108395
SGTC_3337 9144342 33.5465 µM 0.216728368809183 0.408250605900408 no 1359 0.414210019152274 432 17682949
SGTC_785 1270-0111 65.3 µM 0.216127276592778 0.408492410256904 no 1360 0.414444269243901 426 6741994
SGTC_1798 st045719 60.953 µM 0.215515986425713 0.408738352728358 no 1361 0.414682524764866 470 3980186
SGTC_1687 st020778 55.3625 µM 0.214979112041882 0.408954384890902 no 1362 0.414891801997866 461 4259299
SGTC_138 0850-0259 40.9225 µM 0.214744730990673 0.409048705844988 no 1363 0.414983172880488 451 6813004
SGTC_2293 7624732 200 µM 0.214637469185312 0.409091872506948 no 1364 0.415024989253311 441 894453
SGTC_2199 6590217 200 µM 0.21432561779083 0.409217380885219 no 1365 0.415146571027051 434 703109
SGTC_2724 maprotiline 69.64 µM 0.212859691537872 0.409807485191353 no 1366 0.415718201665897 462 4011 A tricyclic antidepressant.
SGTC_1748 st037455 53.6035 µM 0.210462946260808 0.410772727579504 no 1367 0.41665318428751 450 580690
SGTC_353 1988-1175 58.3 µM 0.210121687157027 0.410910207125193 no 1368 0.416786349699789 448 2788357
SGTC_598 3937-0236 20.2 µM 0.20775991403849 0.4118619694632 no 1369 0.417708216783917 460 1379313
SGTC_3130 9127414 49.47 µM 0.203772294710522 0.413470100235816 no 1370 0.419265722093349 460 1494646
SGTC_599 1935-0052 86.5 µM 0.203539203777016 0.413564146557696 no 1371 0.419356803372241 442 9557311
SGTC_867 0518-0118 155 µM 0.203347836197944 0.413641362263801 no 1372 0.419431584302451 473 6848158
SGTC_560 2332-1943 155 µM 0.201886560600303 0.414231088376576 no 1373 0.420002704417819 473 21177716
SGTC_231 b-estradiol 524 µM 0.199016973010996 0.415389727811697 no 1374 0.421124733811584 447 450 A steroid.
SGTC_713 1488-1073 324 µM 0.198712237692104 0.415512812722174 no 1375 0.421243925317189 473 3312542
SGTC_2746 daunorubicin 9.88 µM 0.198564534919034 0.415572473978101 no 1376 0.421301699084854 463 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.198431354658187 0.415626270856368 no 1377 0.421353793841543 446 688801
SGTC_2413 inermin 26.06 µM 0.197226424645242 0.416113062439919 no 1378 0.421825176422254 478 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1730 st033808 45.1 µM 0.195726236000129 0.416719318296255 no 1379 0.422412224103393 486 1045166
SGTC_409 arachidonic acid 100 µM 0.195109400761705 0.416968651160533 no 1380 0.422653651632448 438 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_258 haloperidol 50.781 µM 0.194808347222469 0.417090353070248 no 1381 0.422771493674619 484 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1572 epiandrosterone 68.9 µM 0.194541283991493 0.417198320933437 no 1382 0.4228760366017 445 441302 A steroid.
SGTC_2792 7535235 81.82 µM 0.193755591357357 0.417515995576809 no 1383 0.423183630468745 430 1281891
SGTC_834 0312-0008 75.7 µM 0.193240379510238 0.417724337501485 no 1384 0.423385358193452 443 6385573 YIL048W NEO1
SGTC_2904 7225135 42.03 µM 0.192955095366054 0.417839710951364 no 1385 0.423497067919604 467 4446116
SGTC_699 0375-0592 111 µM 0.191423004991534 0.418459433419034 no 1386 0.424097098965394 468 762578
SGTC_3015 9080845 49.47 µM 0.191176290293216 0.418559247177644 no 1387 0.424193739308859 467 5296973
SGTC_100 0086-0128 49.5915 µM 0.191049325827361 0.418610615437978 no 1388 0.42424347419714 461 93297
SGTC_957 1187-1561 14.1 µM 0.190024790650563 0.419025180475771 no 1389 0.424644852163161 475 1538454
SGTC_327 1273-0057 3.96 µM 0.189915847691988 0.419069268146156 no 1390 0.424687536905523 482 3108138
SGTC_1964 st076914 61 µM 0.189823062826537 0.419106817666774 no 1391 0.42472389147123 478 24208661
SGTC_866 0495-0101 262 µM 0.189423700509815 0.419268445788997 no 1392 0.424880375196668 462 635694
SGTC_364 0083-0097 67.7 µM 0.189364825090311 0.419292274737154 no 1393 0.42490344558837 433 5207356
SGTC_531 3788-1495 174 µM 0.189028511044914 0.419428398504749 no 1394 0.425035235510397 435 2896655
SGTC_453 enantio-paf c16 10 µM 0.188911638124946 0.419475705306336 no 1395 0.425081035955619 477 13871343 A lipid and platelet activating factor
SGTC_3315 9136395 68.55 µM 0.186991014465279 0.420253284839828 no 1396 0.425833839053208 494 16876844
SGTC_2796 7949634 45.45 µM 0.186926001351951 0.420279611372964 no 1397 0.42585932618573 445 2971588
SGTC_853 0419-0306 21 µM 0.186135340193788 0.420599811708734 no 1398 0.426169314344923 470 762713
SGTC_1821 st053465 65.6 µM 0.185369844411956 0.420909870687026 no 1399 0.426469479588575 431 675086
SGTC_1836 st055642 81 µM 0.184845303135561 0.421122360985989 no 1400 0.426675186659331 478 8571
SGTC_1161 k007-0610 110 µM 0.182758199931885 0.421968068050014 no 1401 0.427493873879276 470 5843850
SGTC_3138 9097216 49.47 µM 0.182416711507304 0.422106475631463 no 1402 0.42762785597208 482 25237486
SGTC_2444 5485484 36.41 µM 0.182186881595489 0.422199632675509 no 1403 0.427718033838506 464 6790631
SGTC_1318 1280-3875 124 µM 0.181998709897914 0.422275907621009 no 1404 0.427791869172929 454 373245
SGTC_2047 4141938 200 µM 0.179821386710512 0.423158691634408 no 1405 0.42864639656522 476 3807862
SGTC_721 1187-1332 279 µM 0.179763202984914 0.423182287228001 no 1406 0.42866923636272 480 25730
SGTC_1675 st018485 24.5 µM 0.179029257919459 0.42347995198361 no 1407 0.428957364160624 485 3323024
SGTC_1440 4100-1550 40 µM 0.178288478496343 0.423780432825447 no 1408 0.429248213341907 479 742806
SGTC_2094 5332512 191.667 µM 0.178041271330107 0.423880716834666 no 1409 0.429345281832487 474 755774
SGTC_3067 9117431 49.47 µM 0.177892774705055 0.4239409595175 no 1410 0.429403592646564 463 17150885
SGTC_3213 9129884 49.47 µM 0.177168712148517 0.424234725441826 no 1411 0.429687935475963 429 17190742
SGTC_1362 1611-0397 101 µM 0.176177769421682 0.424636837921384 no 1412 0.430077142520234 443 27816
SGTC_1409 3909-8004 61.9 µM 0.17405687176455 0.425497735437072 no 1413 0.430910383547153 445 2119279
SGTC_3243 9134147 49.47 µM 0.173581858542688 0.425690597784678 no 1414 0.431097045176857 473 24282180
SGTC_659 k018-0002 107 µM 0.173570619769318 0.425695161107284 no 1415 0.431101461762061 458 6797879 YHR007C ERG11
SGTC_1979 st071809 45.3 µM 0.172467803661691 0.426142990102958 no 1416 0.431534885508647 483 4976333
SGTC_1382 3002-2117 298 µM 0.172441055864723 0.426153852971583 no 1417 0.431545398831702 481 1497314
SGTC_1729 st035615 45.989 µM 0.172119503847978 0.426284446700887 no 1418 0.431671789864951 456 17385451
SGTC_962 1254-0300 21.5 µM 0.171163864328644 0.426672613611493 no 1419 0.432047460115777 462 7340576
SGTC_2722 naftopidil 47.16 µM 0.170589527277358 0.426905935187161 no 1420 0.432273266619024 476 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1371 2421-0008 32.7 µM 0.170457138717726 0.426959721012424 no 1421 0.432325319679635 470 2827552
SGTC_963 1269-2853 151 µM 0.16879824565345 0.427633798373128 no 1422 0.432977669145304 430 3668223
SGTC_2814 7977482 42.97 µM 0.166606525667762 0.428524709194738 no 1423 0.433839829365205 482 6456762
SGTC_719 2810-4230 27.3 µM 0.166455663725748 0.428586046421832 no 1424 0.433899185785404 488 721079
SGTC_574 1315-0397 40 µM 0.166389832552718 0.428612812504294 no 1425 0.433925087435617 478 6794277
SGTC_1367 1812-0510 76.9 µM 0.165259626199088 0.429072390536775 no 1426 0.434369817723364 455 1142582 YDR527W RBA50
SGTC_1842 st055362 61.2 µM 0.164431765725862 0.429409086126029 no 1427 0.43469562923105 451 676032
SGTC_614 0462-0418 107 µM 0.164047520287637 0.429565378409354 no 1428 0.434846867365074 471 5188303
SGTC_2104 5389443 200 µM 0.163112973118055 0.429945552601015 no 1429 0.435214742761509 465 2244536
SGTC_3192 9110362 49.47 µM 0.162088068310264 0.430362558995126 no 1430 0.435618251028751 468 16649480
SGTC_974 1326-0144 138 µM 0.161228084416468 0.430712523427124 no 1431 0.435956881152349 474 5411856
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.1605471939697 0.430989645647733 no 1432 0.436225024161345 462 4000243
SGTC_1008 4106-0037 6 µM 0.158852702349393 0.431679450484593 no 1433 0.436892462733491 502 2905394
SGTC_308 4092-1169 104 µM 0.158316575378657 0.431897744087608 no 1434 0.437103673796049 469 2268590 YDL196W YDL196W
SGTC_2249 haloperidol 116.36 µM 0.154296858295737 0.433535101157574 no 1435 0.43868783718537 494 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1320 1313-0481 95.3 µM 0.153874681736504 0.43370713365165 no 1436 0.438854273686258 479 6813365 YLR208W SEC13
SGTC_235 0330-0087 5 mM 0.153376643255669 0.433910095223261 no 1437 0.439050631461554 467 46494818 YHR062C RPP1
SGTC_2508 celastrol 40.54 µM 0.153102545614484 0.434021803443413 no 1438 0.439158704218387 457 122724 Celastrol is a natural product and antioxidant.
SGTC_2842 9000675 19.48 µM 0.152860266352731 0.434120548502407 no 1439 0.439254235222399 496 2989072
SGTC_1771 st048882 4.1505 µM 0.151726399782685 0.434582729766593 no 1440 0.439701367108851 440 4580403
SGTC_2472 5377652 49.4 µM 0.15131255874498 0.434751439976471 no 1441 0.439864581450549 474 1610903
SGTC_2378 9074213 121.43 µM 0.150474452236829 0.435093146480758 no 1442 0.440195152695632 487 657714
SGTC_1476 4112-3294 3.34 µM 0.149971633328105 0.435298175321673 no 1443 0.440393497719312 493 704369
SGTC_414 piperonyl butoxide 100 µM 0.149609809952879 0.43544572275721 no 1444 0.440536234039065 480 5794 A potent inhibitor of cytochrome P450.
SGTC_1634 st006576 41 µM 0.148724505914963 0.435806777479034 no 1445 0.440885511682563 487 3915356
SGTC_1119 parthenolide 318.541 nM 0.14745441376184 0.436324854225534 no 1446 0.441386679442562 487 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_641 4092-0595 30 µM 0.145590513374776 0.437085345809919 no 1447 0.442122328707089 463 786260
SGTC_2328 6201408 200 µM 0.144948363199794 0.437347404049125 no 1448 0.442375820649935 471 2890418
SGTC_501 nsc-95397 161 µM 0.144653288602797 0.437467831724719 no 1449 0.44249231071829 482 262093
SGTC_1640 st009078 66.4 µM 0.143854476437883 0.437793876941421 no 1450 0.442807692111921 489 690618
SGTC_281 1672-3440 14.9 µM 0.142745611039995 0.438246544245945 no 1451 0.443245546572258 492 6833000
SGTC_3036 9090181 49.47 µM 0.141790061567448 0.438636688900945 no 1452 0.443622917236929 473 25236586
SGTC_361 000s-0510 1.45 µM 0.141766225817996 0.438646421646824 no 1453 0.443632331232545 461 660
SGTC_1256 0570-0116 285 µM 0.141142835539608 0.438900980991727 no 1454 0.443878552238674 461 410638
SGTC_1138 3761-0006 1.03 µM 0.140818553697284 0.439033410402335 no 1455 0.444006642695176 488 12061087
SGTC_15 0266-0086 27.098 µM 0.13960075745414 0.439530791814497 no 1456 0.444487721060581 491 1712902 YIL048W NEO1
SGTC_246 cycloheximide 667 µM 0.138942760859404 0.439799575462898 no 1457 0.444747690190737 480 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.138386356811234 0.440026881444391 no 1458 0.444967539479358 464 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2450 5739737 12.93 µM 0.137561211411261 0.440364011853913 no 1459 0.445293606410196 500 2262825
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.137506900161836 0.440386203369905 no 1460 0.445315069507063 478 688662
SGTC_1563 conessine 56.1 µM 0.137484449478924 0.440395376748628 no 1461 0.445323941770738 496 441082 An anti-amoebic, histamine inhibitor.
SGTC_3046 9092212 49.47 µM 0.134905658131489 0.44144928595889 no 1462 0.446343232954333 478 25236637
SGTC_2149 5554786 194.827 µM 0.13314760024187 0.442168013224878 no 1463 0.447038325348943 464 745063 YPR165W RHO1
SGTC_580 1123-0028 41 µM 0.133133076408318 0.442173951638591 no 1464 0.447044068392379 498 1677248 YPR107C YTH1
SGTC_562 3772-2733 112 µM 0.133113470247545 0.442181968102902 no 1465 0.447051821117467 507 2876874 YIL048W NEO1
SGTC_2923 7992654 58.14 µM 0.133067263683594 0.442200860894369 no 1466 0.447070092331335 498 2985126
SGTC_828 2074-0507 139 µM 0.13275914985062 0.442326844847907 no 1467 0.447191931002838 501 X828
SGTC_1124 fisetin 1.16336 µM 0.13252486738205 0.442422643969957 no 1468 0.447284577582133 463 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2575 plumbagin 510 nM 0.132133311663076 0.4425827603225 no 1469 0.447439424003159 493 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1384 3089-0840 101 µM 0.131845515571957 0.442700452901918 no 1470 0.447553242275385 465 1069836
SGTC_1275 0867-0008 21.1 µM 0.13088163276808 0.443094664078059 no 1471 0.447934472306414 483 3422836
SGTC_1850 st056238 17 µM 0.13083024565019 0.443115682093957 no 1472 0.447954798031809 504 5393177
SGTC_685 1278-0033 54.9 µM 0.130565678763741 0.44322389600773 no 1473 0.448059447313341 501 3590572
SGTC_2708 st078559 56 µM 0.129535227632266 0.443645414406878 no 1474 0.448467076065978 503 17250902
SGTC_419 nsc-638432 893 µM 0.128999566873015 0.443864558088569 no 1475 0.448678995775421 442 368090
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.128638830945302 0.44401214810992 no 1476 0.448821719455946 474 15053
SGTC_225 nsc-122657 1.016 µM 0.127167292951382 0.444614287374015 no 1477 0.449403995809091 494 275685
SGTC_1416 3966-0321 25.3 µM 0.124913765084136 0.445536656739951 no 1478 0.450295910383452 477 582530 YLR208W SEC13
SGTC_1919 st067113 52.3 µM 0.124234418554502 0.445814771471623 no 1479 0.450564835629697 489 1268243
SGTC_1661 st013063 9.66 µM 0.12348045455054 0.446123464739666 no 1480 0.450863325422697 486 721395
SGTC_2966 9084041 48.03 µM 0.123172657239625 0.446249494686807 no 1481 0.450985188515944 455 17741380
SGTC_1129 3453-1384 223 µM 0.122807294492299 0.446399102286684 no 1482 0.451129848909589 495 1084452
SGTC_2700 st077718 96.8 µM 0.122638904749953 0.446468056563924 no 1483 0.45119652271635 469 904970
SGTC_1279 0874-0590 65.2 µM 0.122551986080566 0.446503649710065 no 1484 0.451230938644735 474 3523074
SGTC_3137 9097352 49.47 µM 0.121552823391335 0.446912837151431 no 1485 0.451626588908429 496 44120435
SGTC_2870 9038528 12.99 µM 0.121318119972708 0.447008963537615 no 1486 0.451719534180385 486 6463316
SGTC_1632 st005650 90 µM 0.121253632049235 0.447035376101583 no 1487 0.451745072608636 476 2759605
SGTC_2375 9072683 200 µM 0.120517315902026 0.447336968530911 no 1488 0.452036681756222 503 16798029
SGTC_1158 4092-0494 91.8 µM 0.120389011332877 0.447389524738661 no 1489 0.452087497888455 494 1148199
SGTC_1145 3546-0597 10.2 µM 0.118424616562587 0.448194296304469 no 1490 0.452865610910837 480 875334
SGTC_3134 9127454 49.47 µM 0.118003885215397 0.448366689004089 no 1491 0.453032289718782 500 24262820
SGTC_528 3492-0019 172 µM 0.117186602441405 0.448701594633282 no 1492 0.453356091734441 495 2869262
SGTC_2414 st077232 92.9 µM 0.115945917981203 0.449210071339113 no 1493 0.453847701895758 465 729801
SGTC_697 0508-1955 564 µM 0.115563516715934 0.449366809862428 no 1494 0.453999239282763 495 6243113
SGTC_2969 9091408 28.7 µM 0.113982356709146 0.450014978888091 no 1495 0.454625889795108 460 4286311
SGTC_802 4112-3352 742 µM 0.113538003599056 0.450197157792564 no 1496 0.454802017672752 450 704594
SGTC_480 am 92016 50 µM 0.111438269123303 0.451058162519302 no 1497 0.455634407331149 503 2129 K+ channel blocker.
SGTC_1331 1472-0049 76.2 µM 0.11073820018462 0.451345280055378 no 1498 0.455911976445449 513 24051409
SGTC_1757 st041620 31.8375 µM 0.109318987068955 0.451927416362791 no 1499 0.456474743672332 482 5289815
SGTC_1653 st012112 65 µM 0.108989943886439 0.45206239890813 no 1500 0.45660523321747 501 720429
SGTC_1789 tunicamycin 25 nM 0.108943431011261 0.452081480213646 no 1501 0.456623679332062 502 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_9 0092-0002 10.449 µM 0.108213779332183 0.452380824838259 no 1502 0.456913057408598 494 759368
SGTC_1045 1348-1485 165 µM 0.106376013197815 0.453134900622443 no 1503 0.457642011886834 478 6810614
SGTC_1677 st019204 53.9 µM 0.105664370460913 0.453426948806448 no 1504 0.457924325150052 462 3945625
SGTC_1449 4112-4002 201 µM 0.103950911715898 0.454130231249262 no 1505 0.458604152106228 475 2059539
SGTC_976 1348-1067 47.6 µM 0.101578926136168 0.455104040390064 no 1506 0.459545453709014 486 5310671 YGL099W LSG1
SGTC_1209 2323-2347 50.3 µM 0.100566852286333 0.455519625712604 no 1507 0.459947155653267 498 5412760
SGTC_855 0428-0020 25 µM 0.100258528963172 0.455646241432575 no 1508 0.460069540320135 492 6812414
SGTC_2184 6075246 200 µM 0.0998302416355094 0.455822128912416 no 1509 0.460239549309858 507 2267320
SGTC_340 k038-0059 454 µM 0.0995292047669979 0.455945762820976 no 1510 0.460359050482406 491 23733424
SGTC_1106 tegaserod maleate 11.7 µM 0.0994302194134247 0.455986416402498 no 1511 0.460398345009729 487 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2215 7188065 200 µM 0.0991864254257667 0.456086545288419 no 1512 0.460495126324718 501 940217
SGTC_2476 5806916 10.51 µM 0.0991612868891845 0.456096870122025 no 1513 0.460505105951876 505 2870194
SGTC_2560 caryophyllene 100 µM 0.0990675120999666 0.456135385318234 no 1514 0.460542333375451 519 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2226 7298446 200 µM 0.0985147554174549 0.456362421993362 no 1515 0.460761777911924 501 3283010
SGTC_1800 st050079 29.0735 µM 0.0982269345595596 0.456480645821724 no 1516 0.460876047597459 506 3645560
SGTC_687 k029-0044 34.9 µM 0.098168424322317 0.456504679660031 no 1517 0.460899277533862 504 5829338
SGTC_1027 k015-0025 8.67 µM 0.0979726107489314 0.456585113780112 no 1518 0.460977021084872 455 3598955
SGTC_307 1501-1223 22.3 µM 0.0973658726829681 0.456834354170341 no 1519 0.46121792278978 506 2830329
SGTC_1477 0139-0234 16 µM 0.0969833393427293 0.456991502804965 no 1520 0.461369812675493 498 620880
SGTC_1299 1079-1439 3.74 µM 0.0969733140246552 0.456995621399399 no 1521 0.461373793435548 479 323161
SGTC_812 4251-0442 148 µM 0.0960863071125261 0.45736003921654 no 1522 0.461726013163202 511 5723007
SGTC_955 1216-0110 33 µM 0.0958911535682511 0.457440220898885 no 1523 0.461803510316365 500 3619719
SGTC_2848 9016370 25.97 µM 0.0952136005905298 0.457718616857906 no 1524 0.462072583678754 517 7894410
SGTC_2807 7945238 51.95 µM 0.0950600869766901 0.45778169609703 no 1525 0.462133550219962 512 17148797
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.094939082323064 0.457831418049103 no 1526 0.46218160674919 517 140250 A respiratory chain inhibitor.
SGTC_58 0957-0393 9 µM 0.0949023373427011 0.457846517038349 no 1527 0.462196199985044 491 6997992
SGTC_1654 st012436 41.8 µM 0.0944340503336577 0.458038947567546 no 1528 0.462382184199094 502 4323132
SGTC_214 4373-3496 70 µM 0.0937169538705227 0.458333639004667 no 1529 0.462667001155073 503 3779166
SGTC_1090 efavirenz 20.7 µM 0.0927391923397501 0.458735487859554 no 1530 0.463055380089147 482 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3249 9135183 49.47 µM 0.0921287896742991 0.458986377812154 no 1531 0.463297857432549 504 4902779
SGTC_1666 st014829 29 µM 0.0916898924932559 0.459166785050924 no 1532 0.463472214092171 488 3858230
SGTC_1179 1021-1431 9.29 µM 0.0898084230390312 0.459940251700292 no 1533 0.464219727312223 513 2840958
SGTC_1932 st074806 40.9 µM 0.088888503440012 0.460318483359407 no 1534 0.464585260154802 514 17251235
SGTC_515 4092-1064 102 µM 0.0883853572465446 0.460525370802912 no 1535 0.464785199485609 510 717353
SGTC_472 calcifediol 10 µM 0.0875810112716084 0.460856130016394 no 1536 0.465104847492975 494 5283731 A vitamin D metabolite.
SGTC_3193 9111931 49.47 µM 0.0863235470231977 0.461373272488102 no 1537 0.465604610261495 496 17087244
SGTC_1288 0973-0013 65.5 µM 0.0840600089719735 0.462304335093389 no 1538 0.466504360140845 508 4315430
SGTC_2442 5158906 48.48 µM 0.0830715388900415 0.4627109882533 no 1539 0.466897328140644 523 1893835
SGTC_874 0599-0792 117 µM 0.0830704725909017 0.462711426946184 no 1540 0.466897752067214 510 765305
SGTC_1724 st037281 8.293 µM 0.0825283887505807 0.462934454954059 no 1541 0.467113272184786 506 574124 YDL195W SEC31
SGTC_1196 1588-0294 184 µM 0.081081041282756 0.463529989890316 no 1542 0.467688751452106 512 6144269
SGTC_2541 muurolladie-3-one 83.07 µM 0.0809062208403985 0.463601928197459 no 1543 0.467758266335896 511 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2406 ethylparaben 405.7 µM 0.0801386907460642 0.463917779544443 no 1544 0.468063475461393 462 8434 A possible steroid mimic.
SGTC_3244 9134489 49.47 µM 0.0800783392684448 0.463942616144159 no 1545 0.46808747508653 511 16584271
SGTC_542 3381-0244 89.3 µM 0.0793687569966999 0.464234642884852 no 1546 0.4683696592645 521 1112843
SGTC_3075 9116269 49.47 µM 0.0791698752167603 0.464316495628635 no 1547 0.468448752727605 505 17015205 YNL244C SUI1
SGTC_1005 4092-0690 4.4 µM 0.0790474869271985 0.464366867093752 no 1548 0.468497426049086 508 1529343
SGTC_2570 licareol 100 µM 0.0786346271698768 0.464536792386141 no 1549 0.468661622152867 501 443158
SGTC_2823 7987624 58.44 µM 0.0781495422604165 0.464736452451674 no 1550 0.468854549319794 510 2239440
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0778103100107715 0.464876085106919 no 1551 0.468989472556887 500 4330530
SGTC_818 4072-2707 53.5 µM 0.0767577759084861 0.465309350059167 no 1552 0.469408120767944 492 882871
SGTC_2495 cafestol 54.53 µM 0.0766174297466796 0.465367125247256 no 1553 0.469463946389233 497 16667697 An anti-infammatory.
SGTC_594 1487-1584 10.8 µM 0.0760148186038987 0.465615205664852 no 1554 0.469703654383986 509 5013332
SGTC_1927 st060202 13.8 µM 0.0754243623667396 0.465858295164322 no 1555 0.469938538024684 520 688887
SGTC_906 1165-0455 526 µM 0.0725635315904273 0.467036271486573 no 1556 0.4710767238795 526 3252859
SGTC_913 3487-1245 167 µM 0.0719764589322809 0.467278040704233 no 1557 0.471310321150227 518 4016153
SGTC_1244 0416-0015 52.5 µM 0.0715729712288849 0.467444212672282 no 1558 0.471470875364245 507 96201
SGTC_1041 0206-0046 107 µM 0.0707798489037187 0.467770867879802 no 1559 0.471786484919814 508 50494
SGTC_3208 9114115 49.47 µM 0.070568321476679 0.467857991200126 no 1560 0.471870661666925 516 650895
SGTC_3179 9107801 49.47 µM 0.070342234473638 0.467951112979687 no 1561 0.471960633745665 495 4818259
SGTC_1067 clotrimazole 1.36 µM 0.068831791258766 0.468573286194653 no 1562 0.472561756162601 512 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_440 fluspirilene 35.1 µM 0.0685329251098292 0.468696402591277 no 1563 0.472680705615899 511 3396 An atypical antipsychotic.
SGTC_3142 9086498 49.47 µM 0.0679350409491919 0.46894270691667 no 1564 0.472918672265857 513 25236367
SGTC_3004 9076122 71.4286 µM 0.0679294453158393 0.468945012149765 no 1565 0.472920899455648 518 44782551
SGTC_1881 5652484 16 µM 0.0666567935422961 0.46946933340065 no 1566 0.473427465764494 523 2255129
SGTC_1712 st032288 53.4 µM 0.0625814896080274 0.471148674274421 no 1567 0.475049884836802 517 2883011
SGTC_1167 k781-0610 148 µM 0.0614838758062718 0.471601065138006 no 1568 0.475486927676356 511 4525169
SGTC_731 3966-0296 387 µM 0.0605158467279689 0.472000076985575 no 1569 0.475872397558321 506 660956
SGTC_520 3584-0023 682 µM 0.0601846693488575 0.472136591441727 no 1570 0.476004277833636 495 1340790
SGTC_1053 3366-3204 134 µM 0.0600591431808584 0.472188335374865 no 1571 0.476054265104541 511 3632071 YPR165W RHO1
SGTC_2883 9059145 45.46 µM 0.0591246593191787 0.472573559554938 no 1572 0.47642640884937 525 16476510
SGTC_2236 dapsone 200 µM 0.0587490804282984 0.472728392451659 no 1573 0.47657598314473 525 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2859 9028643 45.46 µM 0.0584970085613506 0.472832311726086 no 1574 0.476676372619283 508 17151580
SGTC_2364 9055074 200 µM 0.0583797343020867 0.472880659901801 no 1575 0.476723078460319 509 6470630
SGTC_2960 9079389 5.97 µM 0.0578570089515179 0.473096166577954 no 1576 0.476931263805745 525 16457355
SGTC_152 4469-0003 551.229 µM 0.0568892661955716 0.473495163613084 no 1577 0.477316702400644 508 697280
SGTC_1185 1319-0113 81.3 µM 0.0561442302244635 0.473802357538649 no 1578 0.477613454430249 523 4672763
SGTC_1832 st054113 55 µM 0.0559219349262896 0.473894017568892 no 1579 0.477701998313185 519 1251267
SGTC_3152 9099253 49.47 µM 0.0556093419736846 0.474022912778314 no 1580 0.477826511102095 514 25236131
SGTC_2597 laccaic acid a 100 µM 0.0527603874942212 0.475197780081841 no 1581 0.478961411858115 522 5491415 A textile dye.
SGTC_175 3793-3120 23.7 µM 0.0524381431158286 0.475330682735069 no 1582 0.479089791049586 534 5322297
SGTC_382 3229-0966 23.2 µM 0.0523172155799543 0.475380557364219 no 1583 0.479137968026264 523 5722370
SGTC_2630 antimycin a 100 µM 0.0519227322974413 0.475543258366007 no 1584 0.479295130475275 515 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_825 1988-2224 89.6 µM 0.0516419134799701 0.475659081990978 no 1585 0.479407010875179 510 1180859
SGTC_1558 st069300 45.6 µM 0.0516386713330575 0.475660419225389 no 1586 0.479408302581204 533 24208000
SGTC_69 0096-0274 206.684 µM 0.0494756817267454 0.476552611929847 no 1587 0.480270108315508 526 6741392
SGTC_2268 7933382 153.85 µM 0.0492951817334719 0.476627070172707 no 1588 0.480342029635637 502 935025 YOR257W CDC31
SGTC_1127 asiatic acid 681.4 nM 0.0484966438445968 0.476956485636141 no 1589 0.480660219560259 507 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1172 0370-0043 85 µM 0.047599706322503 0.477326512004784 no 1590 0.481017633043295 523 376585
SGTC_1498 4478-3555 97.6 µM 0.0470411545408307 0.477556949197895 no 1591 0.481240213618563 527 3437919
SGTC_217 ketoconazole 989 nM 0.0449011297370408 0.478439910712712 no 1592 0.482093058177261 524 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2917 7979103 53.79 µM 0.0444308041222846 0.478633978602216 no 1593 0.482280503873889 531 2980565
SGTC_88 0180-0332 8.668 µM 0.0441452234098553 0.478751818686537 no 1594 0.482394322415958 529 3101745
SGTC_1526 st051518 75 µM 0.0439914117331924 0.47881528726173 no 1595 0.482455624842863 500 673993
SGTC_3262 9137218 49.47 µM 0.0432861383469729 0.479106316864984 no 1596 0.482736720431418 535 17650664
SGTC_99 0109-0120 622.8 µM 0.0432363802542267 0.479126849861485 no 1597 0.482756552471525 534 759414
SGTC_2470 5664817 21.68 µM 0.0412810476755064 0.479933773716324 no 1598 0.483535920976888 526 2859561
SGTC_2020 4017018 200 µM 0.0409570963977553 0.480067469496801 no 1599 0.483665049627707 525 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_651 3253-0966 34.4 µM 0.0409159622417833 0.480084445861893 no 1600 0.483681446037387 520 781462
SGTC_1509 1326-1131 80 µM 0.040534819553463 0.480241747933154 no 1601 0.483833373926882 526 768313
SGTC_2216 7189485 200 µM 0.0397440729235851 0.48056810815552 no 1602 0.484148582152283 523 731273
SGTC_1814 st052110 31.539 µM 0.0394054512974315 0.480707869470785 no 1603 0.484283566890002 517 674163
SGTC_2005 4024620 188 µM 0.0392213054711848 0.480783874068096 no 1604 0.484356973697182 539 236743
SGTC_644 1498-1197 63.3 µM 0.0383779756756231 0.481131960031314 no 1605 0.484693160453931 523 6741615
SGTC_1037 k284-1091 78.7 µM 0.037752707658906 0.481390049886214 no 1606 0.484942425643972 529 3334711
SGTC_1 0258-0098 57.368 µM 0.0367385537336032 0.48180867545697 no 1607 0.485346733973277 509 6790032 YDR047W HEM12
SGTC_2 0422-0095 29 µM 0.0365491325662825 0.481886867545015 no 1608 0.485422251367295 509 6790840
SGTC_2460 5552655 174.22 µM 0.036487538580307 0.481912293377338 no 1609 0.485446807433208 500 5401989
SGTC_18 0111-0177 500 nM 0.0363843745628835 0.48195487937198 no 1610 0.485487936611377 532 721752
SGTC_1238 0333-0287 48.8 µM 0.0361469857072181 0.48205287401569 no 1611 0.485582578805423 532 7226
SGTC_3203 9113543 49.47 µM 0.0338717451515953 0.482992152483552 no 1612 0.486489712178644 522 17018012
SGTC_2227 7312221 64.1025 µM 0.0335950200517403 0.483106398343998 no 1613 0.486600046725702 537 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3104 9120930 49.47 µM 0.033433443920171 0.483173105635266 no 1614 0.486664470085577 530 17014836
SGTC_2681 menadione 3.18 µM 0.0325351553966733 0.483543975843542 no 1615 0.487022640454323 535 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1565 sinapyl alcohol 95.1 µM 0.0320377678624472 0.483749334961074 no 1616 0.487220965973676 540 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1556 plumbagin 1.48 µM 0.0317618306731052 0.483863264523564 no 1617 0.487330992989055 535 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2856 9022925 19.48 µM 0.0316881391803126 0.48389369065484 no 1618 0.487360376850452 531 4944862
SGTC_1309 pyrazolanthrone 13.4 µM 0.0312580143965039 0.484071284704321 no 1619 0.487531886845197 536 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1121 fusaric acid 630.51 nM 0.0299758149525734 0.484600710130942 no 1620 0.488043170686537 522 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1700 st030840 7.9285 µM 0.0299229790688146 0.484622526873562 no 1621 0.488064239703269 523 5499307
SGTC_1228 0124-0032 52.5 µM 0.0293463523870484 0.484860627807747 no 1622 0.488294179473183 533 X1228
SGTC_546 peri-Naphthalide 147 µM 0.0269118059946482 0.485865960240604 no 1623 0.489265038553311 533 223824 A penicillin ester.
SGTC_2707 st078556 66.6 µM 0.0266375546751353 0.485979216550843 no 1624 0.489374409789534 538 17250899
SGTC_1104 tacrolimus 29.8 µM 0.0252306262061646 0.486560246936352 no 1625 0.489935504273678 526 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1356 1502-0781 85.8 µM 0.0243652491656808 0.486917642792213 no 1626 0.490280633620009 531 567702
SGTC_3347 9188721 44.724 µM 0.0237966123383344 0.48715249234558 no 1627 0.490507421124001 541 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1207 2099-0101 141 µM 0.0235019750132182 0.487274180636351 no 1628 0.490624931544206 533 5837381
SGTC_889 0919-1524 82.7 µM 0.0227056080713571 0.487603094393057 no 1629 0.490942551197992 524 3905452
SGTC_2774 tamoxifen 10.92 µM 0.0224503396106848 0.487708526617487 no 1630 0.491044362626277 537 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_33 0986-0033 35.816 µM 0.0220512754109379 0.48787335177769 no 1631 0.49120352680125 538 2848082
SGTC_394 menadione 8.33 µM 0.0203445925409623 0.488578284632941 no 1632 0.491884241717099 543 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.019818538362745 0.488795574753865 no 1633 0.492094064656315 533 688751
SGTC_918 glabranin 770.725 nM 0.0197990505286844 0.488803624395537 no 1634 0.49210183765211 536 124049 Also referred to as licorice root.
SGTC_2471 5466956 24.79 µM 0.0194214725156269 0.488959587606483 no 1635 0.492252440523892 542 724419
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0181518222713075 0.489484044395914 no 1636 0.492758868276948 537 551469
SGTC_272 doxorubicin 8.13 µM 0.0161321246716823 0.490318361742694 no 1637 0.493564492532222 534 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1265 0819-1001 68.8 µM 0.0147463392350153 0.490890840893953 no 1638 0.494117275002973 540 3106768
SGTC_730 1436-0052 41.2 µM 0.0140628554124408 0.491173200561932 no 1639 0.494389917305389 535 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1224 0823-0416 294 µM 0.0137109237100332 0.491318591719061 no 1640 0.494530304203411 537 3598164
SGTC_647 0140-0236 81 µM 0.0108949996858578 0.492481955224432 no 1641 0.495653609967341 539 990837
SGTC_2761 levamisole 97.89 µM 0.00961647583377769 0.493010182937075 no 1642 0.49616364033046 543 26879 An alkaline phosphatase inhibitor.
SGTC_1417 3966-0327 90.4 µM 0.00936568109276971 0.493113801346614 no 1643 0.496263688449791 545 651118
SGTC_3199 9111318 49.47 µM 0.00885185392887471 0.493326095732528 no 1644 0.496468667324344 542 8548020
SGTC_1833 st055984 71 µM 0.00704363291432653 0.49407320042803 no 1645 0.497190020258011 545 676288
SGTC_370 0180-0345 38.7 µM 0.00604494987015703 0.494485836495783 no 1646 0.497588428600936 538 3989527
SGTC_54 0159-0055 9 µM 0.00604260168068349 0.494486806728323 no 1647 0.497589365375891 545 3319099
SGTC_985 1493-0307 8.71 µM 0.00526188062578419 0.494809389357985 no 1648 0.497900823030742 543 3278274
SGTC_1520 flindersine 88 µM 0.00523398931224444 0.49482091370873 no 1649 0.497911949901746 545 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2731 amoxapine 43.43 µM 0.00476655295722962 0.495014053348033 no 1650 0.49809842769422 546 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3056 9094900 49.47 µM 0.00461759769353001 0.495075600297446 no 1651 0.498157851592614 539 25236784
SGTC_104 0074-0074 590.992 µM 0.00385909670161789 0.495389007740911 no 1652 0.498460446982899 543 3943124
SGTC_1763 st044482 94.5 µM 0.0038098829021839 0.495409342648028 no 1653 0.498480080303933 545 88505
SGTC_1441 4106-0040 13 µM 0.00339466172305996 0.495580910527798 no 1654 0.498645728512054 543 2904180
SGTC_910 3454-3003 490 µM 0.00299909692922583 0.495744357221434 no 1655 0.498803535225527 546 820824
SGTC_2428 5615643 7.78 µM 0.00264151241396949 0.495892111144718 no 1656 0.498946190239371 547 2253075
SGTC_1743 st037606 46.3785 µM 0.00221534150845666 0.496068205699081 no 1657 0.499116207329652 547 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2203 7227154 166.4 µM 0.00173608817049624 0.496266234919721 no 1658 0.4993074013742 548 896304
SGTC_464 bw-b 70c 158 µM 0.000875376089093023 0.496621886556659 no 1659 0.499650775511409 546 5353454
SGTC_2980 9014342 25.29 µM 0.000746862578923468 0.496674989383317 no 1660 0.499702044967318 546 2996599
SGTC_3151 9099821 49.47 µM -6.53850291028447e-05 0.497010618019315 no 1661 0.499973915147404 550 17174189
SGTC_349 k015-0014 24 µM -0.000377933420525061 0.497139766640625 no 1662 0.499849226382965 550 2196908
SGTC_110 0850-0284 111.64 µM -0.000511333141700717 0.49719488904509 no 1663 0.499796007599294 550 3906265
SGTC_1206 3978-0017 132 µM -0.00103795951899063 0.497412498050114 no 1664 0.499585914136883 550 3873677
SGTC_1316 1272-0050 65.9 µM -0.00117268224476565 0.49746816739381 no 1665 0.499532167578313 550 7340392
SGTC_1092 toremifene 6.32 µM -0.00188366623507906 0.497761956867422 no 1666 0.499248526341059 549 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2875 9039966 71.43 µM -0.00189468665635534 0.497766510684237 no 1667 0.499244129836909 551 6463691
SGTC_1710 st031758 61.5 µM -0.00208485123122955 0.497845089816239 no 1668 0.499168265298053 549 5394341
SGTC_2647 atorvastatin 60.16 µM -0.00256528637197334 0.498043613888749 no 1669 0.49897659992733 549 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_422 cantharidin 155 µM -0.002902376626116 0.498182905678068 no 1670 0.498842120875815 550 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1624 st003710 6.25 µM -0.00294003274921332 0.498198465883213 no 1671 0.498827098320294 548 24207033
SGTC_1917 st066507 28.5 µM -0.00402103958352001 0.498645158936519 no 1672 0.498395841621842 544 3156428
SGTC_1012 4112-3522 18 µM -0.00402251116223343 0.498645767022755 no 1673 0.498395254551623 558 3112398
SGTC_3356 9151811 4.48 µM -0.0048362556305258 0.498982023219792 no 1674 0.498070620671317 549 1859254 YPR165W RHO1
SGTC_473 2-arachidonoylglycerol 10 µM -0.00494637968392867 0.49902752883778 no 1675 0.498026688055895 543 5282280 An endocannabinoid.
SGTC_48 0382-0018 55 µM -0.00707947923312445 0.499908973048574 no 1676 0.497175720002396 553 762596
SGTC_1980 st071811 45.7 µM -0.0075200501425079 0.499908973048574 no 1677 0.496999962323374 554 4974850
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.00791324653227819 0.499746495387717 no 1678 0.496843104330258 550 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1428 4049-0204 61.7 µM -0.00837522252609051 0.499555596491171 no 1679 0.496658808687568 551 X1428
SGTC_2109 5483026 200 µM -0.00944203211115121 0.499114767179583 no 1680 0.496233230147196 550 759335
SGTC_2896 9052656 71.43 µM -0.00953078454217919 0.499078092753734 no 1681 0.496197824643123 552 6469436
SGTC_2022 5136654 200 µM -0.0096369863829834 0.499034207864279 no 1682 0.496155458184332 555 1713771
SGTC_514 4466-0038 2.65 nM -0.00986306394564665 0.498940787782606 no 1683 0.496065270572982 557 5722064
SGTC_2678 equilin 100 µM -0.0102005830365365 0.498801317788875 no 1684 0.495930626713102 552 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2985 9022375 71.43 µM -0.0115664208826456 0.498236926510304 no 1685 0.495385768560813 574 4939335
SGTC_3188 9110789 49.47 µM -0.0124766502568701 0.497860803575346 no 1686 0.49502266582937 561 849217
SGTC_2781 5567276 71.43 µM -0.0131840255618875 0.497568504838574 no 1687 0.49474048714471 554 2853274
SGTC_3171 9103192 49.47 µM -0.0135642948556612 0.497411372042334 no 1688 0.494588795213434 552 13018434
SGTC_2362 9071156 126 µM -0.0143302975950081 0.497094849827248 no 1689 0.494283234062679 558 653133
SGTC_3216 9129716 49.47 µM -0.0145231217604906 0.497015172674493 no 1690 0.49420631635536 556 8056934
SGTC_1020 4335-0961 93.3 µM -0.015022522670166 0.496808815062486 no 1691 0.494007105958343 572 669075
SGTC_1105 epirubicin 18.1 µM -0.0174560558507569 0.495803267264853 no 1692 0.493036394925074 561 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1853 st056710 91.2 µM -0.0180353247967655 0.49556391419649 no 1693 0.492805336438141 552 269167
SGTC_767 0929-0023 86 µM -0.0185677072900052 0.495343935947033 no 1694 0.492592982121288 558 1204563
SGTC_1152 3909-8331 15.9 µM -0.0187684724519824 0.495260980974527 no 1695 0.492512902364895 559 16001939
SGTC_2766 oltipraz 83.91 µM -0.0190424597007575 0.495147771402015 no 1696 0.492403616799394 553 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3145 9085516 49.47 µM -0.0196745507935192 0.494886597387011 no 1697 0.492151496187366 553 25236195
SGTC_1895 st058434 18.3 µM -0.0225405821090753 0.493702409717508 no 1698 0.491008370186255 577 5393175
SGTC_301 4119-0100 24.5 µM -0.0253208654445516 0.492553704352988 no 1699 0.489899515523929 560 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_589 1227-0070 34.1 µM -0.0253301858431163 0.492549853623903 no 1700 0.489895798415107 556 2841384
SGTC_2138 5575593 77.673 µM -0.0264201964357587 0.492099519880959 no 1701 0.489461092672783 556 762213
SGTC_899 1083-0020 478 µM -0.0268409078326905 0.491925707224568 no 1702 0.489293312614147 563 767123
SGTC_999 SEC7.066 22.7 µM -0.0271653112522685 0.491791684279565 no 1703 0.489163941549951 560 740511 YDR170C SEC7
SGTC_3088 9117578 49.47 µM -0.0274147741535314 0.491688622639417 no 1704 0.489064457303671 558 678341
SGTC_2690 usnic acid 100 µM -0.0278373863236902 0.491514028395476 no 1705 0.488895923766732 560 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0281746050093195 0.491374714023012 no 1706 0.488761445724244 564 6708561
SGTC_2133 5320837 200 µM -0.0287617258279415 0.491132160683342 no 1707 0.488527313303301 572 2841355
SGTC_1144 3486-0183 12.5 µM -0.0290014654769056 0.491033119565928 no 1708 0.488431710902793 579 6744069
SGTC_2266 7929956 200 µM -0.0294599412216825 0.490843715852621 no 1709 0.488248883668854 561 2967153
SGTC_671 0560-0003 407 µM -0.0296165848635332 0.490779004312676 no 1710 0.488186419153598 572 3238678
SGTC_2825 7998094 58.44 µM -0.0300301213520963 0.490608168143932 no 1711 0.488021515316712 568 2987815
SGTC_891 0929-0073 133 µM -0.0301354453936277 0.490564657975162 no 1712 0.487979516111813 568 5603632
SGTC_1291 0993-0025 5.79 µM -0.0301388847406381 0.490563237156443 no 1713 0.487978144633837 563 4353356
SGTC_548 1436-0017 110 µM -0.0305472437047463 0.490394542019234 no 1714 0.487815307957851 563 9677137
SGTC_2102 5377816 72.7585 µM -0.0307659725442104 0.490304184742776 no 1715 0.487728088771151 565 1379702
SGTC_3028 9087778 49.47 µM -0.0309069953261483 0.490245928241786 no 1716 0.487671855563101 556 17217395
SGTC_1845 st056753 3.01 µM -0.0310911534264485 0.49016985285738 no 1717 0.487598422401721 569 5375839
SGTC_2713 st079149 53.4 µM -0.031425139324844 0.490031884789762 no 1718 0.487465246383567 559 3103253
SGTC_1096 rimcazole 32.2 µM -0.0319202331903446 0.489827365947211 no 1719 0.487267831553941 579 18528119 A dopamine reuptake inhibitor.
SGTC_2270 7924575 90.91 µM -0.033904130334385 0.489007863174069 no 1720 0.486476799776352 586 1262135
SGTC_373 0844-0104 25.9 µM -0.0341792153285344 0.488894235406546 no 1721 0.48636712031047 571 5375804
SGTC_1494 4358-1428 177 µM -0.0350124860170666 0.488550046641394 no 1722 0.486034892288259 566 1564571
SGTC_1668 st014914 51.6 µM -0.0368835329763666 0.487777227990155 no 1723 0.485288934797349 566 2839556
SGTC_540 1187-0821 17.3 µM -0.0388632746073941 0.486959564040684 no 1724 0.484499698526454 563 847520
SGTC_557 1315-0110 16.2 µM -0.0390366337236634 0.486887966601652 no 1725 0.484430590686969 561 6833801
SGTC_2311 7694451 200 µM -0.03923305608279 0.486806844537648 no 1726 0.484352289486744 561 2163142
SGTC_3258 9138477 49.47 µM -0.0395675575543653 0.486668697318763 no 1727 0.484218946247643 557 4970355
SGTC_3178 9107506 49.47 µM -0.0397297366021615 0.486601718862637 no 1728 0.484154297003326 564 8897194
SGTC_2340 7987427 183.45 µM -0.0398406938470957 0.486555894757931 no 1729 0.484110066486315 561 2239331
SGTC_1579 chlormadinone acetate 49.4 µM -0.0401652750838078 0.486421847348437 no 1730 0.483980680873497 576 45114258 A steroidal progestin.
SGTC_1295 1013-0063 9.78 µM -0.0407889727679198 0.486164273442626 no 1731 0.483732065250202 571 6826038
SGTC_2217 6934799 96.0675 µM -0.0408324768716625 0.486146307385239 no 1732 0.483714724070864 577 675606
SGTC_374 0880-0231 82.3 µM -0.0410432699339882 0.486059255760764 no 1733 0.483630700243714 567 6833587
SGTC_3341 9147222 25.867 µM -0.0411222012999796 0.486026659490431 no 1734 0.483599237746847 576 1939759
SGTC_326 k292-0812 17.5 µM -0.0412984135277883 0.485953889499356 no 1735 0.48352899890721 585 3579357
SGTC_1234 0326-0494 15.5 µM -0.0414083404971184 0.485908493428052 no 1736 0.483485181873227 560 1547813
SGTC_2551 apiole 73.87 µM -0.0419300466047378 0.485693049183603 no 1737 0.483277231863755 567 10659 A possible DNA adduct former.
SGTC_2347 9049783 174.81 µM -0.0430869817533451 0.485215295147057 no 1738 0.482816098359328 575 6467988 YPL169C MEX67
SGTC_1229 0139-0193 12.2 µM -0.0430872230118214 0.485215195522045 no 1739 0.482816002200423 567 3090752
SGTC_167 3672-0051 66.205 µM -0.043168798490231 0.485181509885965 no 1740 0.482783488545226 572 3237971
SGTC_1827 berberine 7.24 µM -0.0432167351647754 0.485161715048322 no 1741 0.482764382409633 565 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2968 9090663 33.37 µM -0.043321886976138 0.485118294078659 no 1742 0.482722472157492 577 25236811
SGTC_45 0kpi-0036 14.9 µM -0.0433224450679274 0.485118063622931 no 1743 0.482722249719916 556 2795021
SGTC_387 norethindrone acetate 66.7 µM -0.0438510234729706 0.484899797252305 no 1744 0.482511577660911 581 541197
SGTC_1479 0549-0158 134 µM -0.0440258453828517 0.48482760887146 no 1745 0.482441901100376 580 5440202
SGTC_1467 k284-1082 293 µM -0.0442064434071473 0.48475303590933 no 1746 0.482369922990047 579 3334705
SGTC_2650 prasterone 100 µM -0.0443823725753337 0.484680391335022 no 1747 0.482299806224698 560 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1830 st055982 50.3 µM -0.0457290201010435 0.484124351406111 no 1748 0.481763116651109 577 455313 An antimicrobial agent.
SGTC_2808 7946468 45.46 µM -0.0457999579349076 0.484095061538183 no 1749 0.481734846170097 585 2970879
SGTC_1464 k208-0027 110 µM -0.0460247396777843 0.484002250876525 no 1750 0.481645265694266 562 X1464
SGTC_2855 9016525 58.44 µM -0.0497084854425568 0.482481387602256 no 1751 0.480177347207771 571 43811474
SGTC_2288 7946289 167.31 µM -0.0498114315692337 0.482438889046244 no 1752 0.48013632845901 581 1246052
SGTC_3353 9151644 39.2805 µM -0.0505949458974715 0.482115442677608 no 1753 0.47982414512935 584 4909158
SGTC_934 2950-0684 338 µM -0.0508064485763793 0.482028133234687 no 1754 0.479739876147373 575 1121253
SGTC_2970 9090938 41.86 µM -0.052174037130712 0.481463606316608 no 1755 0.479195010058988 586 17217104
SGTC_2323 6148992 148.28 µM -0.0527682766088097 0.481218321703064 no 1756 0.478958268934864 577 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2111 5486399 200 µM -0.0529651246970063 0.481137070153669 no 1757 0.478879847575859 574 689674
SGTC_764 1951-2361 146 µM -0.0549329516999293 0.480324868182919 no 1758 0.478095939921751 590 5438930
SGTC_1051 3253-3903 78 µM -0.0553723006185739 0.480143542109231 no 1759 0.477920931437643 562 5509239
SGTC_2464 5717415 7.67 µM -0.0558098189707206 0.479962975621625 no 1760 0.477746656364937 571 5285744
SGTC_1708 st033234 31.827 µM -0.057141565501092 0.479413381180411 no 1761 0.477216213006766 574 674664
SGTC_362 0310-0100 9.03 µM -0.0578368875117198 0.479126446331722 no 1762 0.47693927767931 571 790235
SGTC_1696 st025591 34.7925 µM -0.0584026481659039 0.478892984856154 no 1763 0.476713952721748 571 2787147
SGTC_3158 9100007 49.47 µM -0.0596401843453733 0.478382340159112 no 1764 0.476221106417491 575 19297233
SGTC_2585 alliin 100 µM -0.0605145705611987 0.478021563417822 no 1765 0.47587290574384 576 87310 A garlic compound which reacts with lipids.
SGTC_1923 st058458 19.1 µM -0.060841421079018 0.477886707637948 no 1766 0.475742751077142 588 3534982
SGTC_2701 st077767 14.721 µM -0.0647297085540018 0.476282631379894 no 1767 0.47419460420601 594 5721188
SGTC_2007 4011539 71.82 µM -0.0648778621992442 0.476221519428481 no 1768 0.474135623428885 570 45595301
SGTC_2846 9008642 19.48 µM -0.0660981785962234 0.475718172078573 no 1769 0.473649830475884 596 2992898
SGTC_1458 k015-0034 6.33 µM -0.0671149511031899 0.475298810609349 no 1770 0.47324509573676 608 3598957
SGTC_3308 9128332 17.569 µM -0.0675863532116134 0.475104393010035 no 1771 0.47305745955855 568 17332805 YDL196W YDL196W
SGTC_655 k060-0012 42 µM -0.0677238787885947 0.475047675259969 no 1772 0.473002720211635 582 5994525
SGTC_1961 st076550 68.7 µM -0.0678526140534827 0.474994583233554 no 1773 0.472951480137264 578 1579337
SGTC_524 r073-0010 27.8 µM -0.068316625760503 0.474803222718411 no 1774 0.472766794802696 593 2772106
SGTC_399 oxolinic acid 75 µM -0.0690299771370272 0.47450904475441 no 1775 0.472482879050275 583 4628 A DNA gyrase inhibitor.
SGTC_83 0170-0301 39.027 µM -0.0704825235314413 0.473910074336097 no 1776 0.471904805077321 576 3089716
SGTC_278 4092-0821 23.9 µM -0.0705063402330346 0.473900253795198 no 1777 0.471895327167428 596 877900
SGTC_1395 3486-0190 4.35 µM -0.0718796885816201 0.473333996535337 no 1778 0.471348827197272 595 6748079
SGTC_616 4092-0450 108 µM -0.0719372040882526 0.473310282981667 no 1779 0.471325941076515 592 787165
SGTC_1975 st070967 30.8 µM -0.072021009746046 0.47327573020902 no 1780 0.471292593953866 585 261391
SGTC_779 1360-0071 233 µM -0.0721069841400206 0.473240283483156 no 1781 0.471258384078216 574 7566
SGTC_1155 4088-0394 48.2 µM -0.0724130104002403 0.473114112416918 no 1782 0.471136615587451 579 2326248
SGTC_1451 4152-0210 104 µM -0.0730575490205881 0.472848385481641 no 1783 0.470880161158822 602 659563
SGTC_2809 7964133 12.99 µM -0.0732122876835443 0.472784592447421 no 1784 0.470818594236184 592 1253665
SGTC_3318 9139014 38.6185 µM -0.0743726733488161 0.472306230663147 no 1785 0.470356926039154 578 16643984
SGTC_1050 3232-1156 69.3 µM -0.0747558176191797 0.472148290554974 no 1786 0.470204497917635 577 700529
SGTC_862 0452-0056 10.2 µM -0.074894456253853 0.4720911418783 no 1787 0.470149343719617 575 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2817 7995342 71.43 µM -0.0751434052664941 0.471988523249591 no 1788 0.470050306508317 592 18879975
SGTC_495 decylubiquinone 155 µM -0.0754321860303305 0.471869488007728 no 1789 0.469935425700761 614 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1761 st044296 37 µM -0.0758767131356414 0.471686259140442 no 1790 0.469758591832723 589 1826700
SGTC_3127 9126946 49.47 µM -0.0766007751772027 0.471387822093078 no 1791 0.46947057113245 579 27243249
SGTC_1459 k035-0031 35.7 µM -0.0770936570856483 0.471184679867796 no 1792 0.469274519448489 576 3877128 YMR208W ERG12
SGTC_51 1013-0126 23.419 µM -0.0785284701888453 0.470593361761769 no 1793 0.468703842104134 579 1627850
SGTC_1913 st060213 96.1 µM -0.0798021682639821 0.470068496990953 no 1794 0.46819729990059 606 688959
SGTC_2069 5228469 200 µM -0.0804387677998097 0.469806186852666 no 1795 0.467944147269687 581 2835210
SGTC_1637 st007924 17.4 µM -0.0805807631943507 0.469747679589851 no 1796 0.467887682597077 578 683336
SGTC_2014 4013930 200 µM -0.0817863842927847 0.469250946326314 no 1797 0.4674082917795 605 64556
SGTC_1296 1068-0102 11.9 µM -0.0825136049477189 0.468951344028519 no 1798 0.467119150021507 603 767053
SGTC_606 k015-0008 38.6 µM -0.0825952661274085 0.468917702133548 no 1799 0.46708668274903 605 1970475
SGTC_2927 9011802 47.9 µM -0.0828074999374327 0.468830269368458 no 1800 0.467002302762255 595 43912568
SGTC_275 trichlorophene 5.69 µM -0.0833300571825989 0.468615000824782 no 1801 0.466794550612293 586 62616
SGTC_2434 5670830 169.91 µM -0.0837576570285586 0.468438857002467 no 1802 0.466624557233144 604 1549830
SGTC_2763 lisinopril 49.32 µM -0.0844405718904589 0.468157552529853 no 1803 0.466353075375185 601 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2398 5228213 48.84 µM -0.0844959116940255 0.468134757799732 no 1804 0.466331076607235 580 80771 YMR134W ERG29
SGTC_2620 irigenin 100 µM -0.0858169178942707 0.467590660200605 no 1805 0.465805978778735 576 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_566 0958-0068 16.5 µM -0.0867958887443549 0.467187479529709 no 1806 0.465416877799589 609 6815365
SGTC_2557 derrustone 83.84 µM -0.0869491123446718 0.467124378752354 no 1807 0.465355980651473 612 629853 An antioxidant.
SGTC_261 5-fluorouridine 15.376 µM -0.087060703497686 0.467078423632982 no 1808 0.465311630402968 583 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1950 st077106 7.18 µM -0.0878678347398661 0.466746046474629 no 1809 0.464990860925814 574 13831864
SGTC_3306 9127676 59.7925 µM -0.0879552960996978 0.466710031219461 no 1810 0.46495610346187 592 41905287
SGTC_2762 leflunomide 42.06 µM -0.0884816832056636 0.466493278798012 no 1811 0.464746920959221 586 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2800 7887935 81.82 µM -0.0891541255565681 0.466216399116932 no 1812 0.464479711318308 600 2961002
SGTC_681 1642-0006 26.6 µM -0.0896292535069978 0.466020773942817 no 1813 0.464290918510741 588 4446530
SGTC_2847 9005661 71.43 µM -0.0899801470310331 0.46587630527117 no 1814 0.464151495598691 587 2991449
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0902079297650559 0.465782525755209 no 1815 0.46406099148992 583 6312947
SGTC_481 bay k-8644 50 µM -0.0905584959108799 0.465638199287414 no 1816 0.463921705917102 632 2303 A calcium channel antagonist.
SGTC_1723 st034307 2.5525 µM -0.0917679108894596 0.465140323519371 no 1817 0.463441219925388 584 867466
SGTC_2412 st077135 33.4 µM -0.0919858721727926 0.465050601916525 no 1818 0.463354632185755 657 13258915
SGTC_2073 5212005 126 µM -0.0929566342118021 0.464651018983674 no 1819 0.462969006438734 588 691789
SGTC_3148 9097893 49.47 µM -0.0932727708678048 0.464520899184419 no 1820 0.462843431730705 584 17174100
SGTC_1753 st043925 64 µM -0.093718343940364 0.464337510640428 no 1821 0.46266644902744 587 670181
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0947370676525239 0.463918253821747 no 1822 0.46226183732254 592 2374 Ca(2+)-ATPase inhibitor.
SGTC_734 2023-0417 80 µM -0.0967279076049 0.46309903761691 no 1823 0.461471238340046 594 3935732
SGTC_2181 6316240 54.2555 µM -0.0972945482252923 0.4628658975642 no 1824 0.461246242673847 598 12779990
SGTC_2372 9071633 200 µM -0.0982093825539242 0.462489522763934 no 1825 0.460883016141322 571 21321366
SGTC_251 melphalan 456.522 µM -0.0982191632520912 0.462485499037705 no 1826 0.460879132981095 609 460612 A DNA alkylator.
SGTC_2767 sibutramine 71.45 µM -0.100589057596338 0.461510651472619 no 1827 0.459938341709786 623 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1101 ebselen 5.29 µM -0.101512618993913 0.46113081008047 no 1828 0.459571770398322 587 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_615 k087-0205 167 µM -0.10282458124109 0.460591288624978 no 1829 0.459051097828958 583 9642773
SGTC_2231 micatex 6.853 µM -0.102830388424675 0.460588900683139 no 1830 0.459048793313545 600 20737 An antifungal of unknown mechanism.
SGTC_2581 avocatin a 64 µM -0.103379059404674 0.460363290958329 no 1831 0.45883106563164 622 6710728 A skin care supplement.
SGTC_791 1348-1292 225 µM -0.105047009892203 0.459677519869898 no 1832 0.458169253271024 595 5437054
SGTC_1920 st075728 45.7 µM -0.105284000386586 0.459580091872644 no 1833 0.458075229126588 581 3400306
SGTC_1002 4049-0206 172 µM -0.105807798491707 0.459364764427541 no 1834 0.457867424612523 586 4662749
SGTC_3186 9110464 49.47 µM -0.106362514204636 0.45913674010276 no 1835 0.457647366826088 601 17018021
SGTC_2844 9010103 25.97 µM -0.106729016520699 0.458986091125807 no 1836 0.457501981112853 629 2480525
SGTC_2193 5925765 200 µM -0.106932030872888 0.458902645606882 no 1837 0.457421450953735 600 877370
SGTC_3319 9138450 16.7555 µM -0.107057573037759 0.45885104458916 no 1838 0.457371652735771 609 2029690
SGTC_1631 benzylvanillin 81.9 µM -0.107669381372957 0.458599585765848 no 1839 0.45712897920411 601 75506
SGTC_2244 6635614 200 µM -0.108154149460804 0.45840035340494 no 1840 0.456936707482216 583 836499
SGTC_3351 9150312 21.596 µM -0.108330875133306 0.458327724419927 no 1841 0.456866615956222 579 4904905
SGTC_914 3820-6779 408 µM -0.108908780265601 0.458090232358098 no 1842 0.456637421214253 599 2893481
SGTC_968 1309-0633 340 µM -0.110518529711438 0.457428779541915 no 1843 0.455999077650718 593 3761976
SGTC_1254 0550-0035 264 µM -0.110592235429695 0.457398496361321 no 1844 0.455969852472521 611 15121435
SGTC_268 camptothecin 39.6153 µM -0.111108364809943 0.457186443239108 no 1845 0.455765207828277 600 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2987 9018338 71.43 µM -0.111162131232868 0.457164353861908 no 1846 0.455743890183818 599 5055682
SGTC_2643 anethole 100 µM -0.111662091773067 0.456958956605396 no 1847 0.45554566884029 614 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1783 st039459 87.517 µM -0.11470674946036 0.45570837942042 no 1848 0.454338781974675 595 729761
SGTC_1308 1187-1617 41.4 µM -0.115848776412602 0.455239410310515 no 1849 0.453886196371873 596 2882570
SGTC_2214 7179297 48.276 µM -0.116227521246776 0.455083893896535 no 1850 0.453736112879886 596 769744
SGTC_2934 9036370 36.88 µM -0.117375246418611 0.454612668602794 no 1851 0.453281349480712 607 6462800
SGTC_2329 6138490 200 µM -0.118222696019807 0.454264769388391 no 1852 0.452945603619495 651 720019
SGTC_1010 4112-3296 15.2 µM -0.118822763118118 0.454018448067586 no 1853 0.452707887042098 588 704384
SGTC_1534 6-azauridine 81.6 µM -0.120005620240503 0.453532949363405 no 1854 0.452239347914118 596 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_115 0527-0192 112.043 µM -0.122632593228267 0.452454968796932 no 1855 0.451199021785957 620 4233931
SGTC_2120 5538279 151.968 µM -0.122779656811382 0.45239463141477 no 1856 0.451140791936484 598 2058197
SGTC_1760 st045453 10.4495 µM -0.122955996619791 0.452322284005514 no 1857 0.451070971547195 602 3323419 YIL048W NEO1
SGTC_3180 9109287 49.47 µM -0.12323305961186 0.452208615822246 no 1858 0.45096127364755 596 18891271
SGTC_799 1310-0557 151 µM -0.123816307231805 0.451969344793149 no 1859 0.450730359933302 644 5354492
SGTC_2062 5245942 200 µM -0.124250342467359 0.451791297847705 no 1860 0.450558531749709 602 1376160
SGTC_3209 9113616 49.47 µM -0.125354572585844 0.451338371967648 no 1861 0.450121425090885 610 16649353
SGTC_102 gallobenzophenone 83.616 µM -0.12568849679988 0.451201417566798 no 1862 0.449989253937728 601 70837
SGTC_1330 1469-0054 61.8 µM -0.125994467447271 0.451075933034131 no 1863 0.449868152006545 607 7102664
SGTC_2835 9006588 71.43 µM -0.12602827698314 0.451062067383523 no 1864 0.449854770616718 603 2345538
SGTC_1622 st003707 19.4 µM -0.126496967345987 0.450869858634981 no 1865 0.449669274735862 631 10140899
SGTC_14 0354-0009 295 µM -0.12756719578623 0.450431003879873 no 1866 0.449245746474299 603 1713507
SGTC_2465 5809242 33.21 µM -0.129720629720686 0.449548157216996 no 1867 0.448393730160383 603 2731748
SGTC_1251 0490-5699 265 µM -0.130120139301622 0.449384396978888 no 1868 0.448235688360488 600 3883818
SGTC_3129 9127257 49.47 µM -0.130539774880017 0.449212396314471 no 1869 0.448069693774238 660 837894
SGTC_3040 9091894 49.47 µM -0.133050934191975 0.448183320273857 no 1870 0.447076549441531 599 25236966
SGTC_2997 9067075 71.4286 µM -0.13381296017899 0.447871109753405 no 1871 0.446775239313634 619 27209819
SGTC_1655 st012546 55.1 µM -0.135162019277483 0.44731846454542 no 1872 0.446241887849492 625 720985 YLR208W SEC13
SGTC_1259 0671-0132 43 µM -0.135351105160435 0.447241013219242 no 1873 0.446167140360807 617 X1259
SGTC_2504 purpurogallin 52.29 µM -0.135660393209615 0.44711433031253 no 1874 0.446044879911511 606 5281571 An antioxidant.
SGTC_1733 st037357 54.9 µM -0.136289908869763 0.446856500388248 no 1875 0.445796050501819 637 1272339 YGL099W LSG1
SGTC_596 1155-0152 116 µM -0.1370290045412 0.446553818592536 no 1876 0.445503934522123 595 280313
SGTC_40 0327-0103 19.753 µM -0.137386142748611 0.446407570955387 no 1877 0.445362791834885 621 409036
SGTC_3149 9097855 49.47 µM -0.138255180625839 0.446051731549976 no 1878 0.445019372970881 594 25236625 YMR079W SEC14
SGTC_2298 7976326 193.81 µM -0.138734471435784 0.445855497963819 no 1879 0.444829988614616 609 2235818
SGTC_3259 9138485 49.47 µM -0.138811247709714 0.445824065077606 no 1880 0.444799652825559 603 17646153
SGTC_1673 st016611 27.3 µM -0.138979062419673 0.445755361435544 no 1881 0.444733347117531 625 5226799
SGTC_161 4065-0411 162.148 µM -0.139532866083224 0.445528644794348 no 1882 0.444514543288948 643 1906281 YLR208W SEC13
SGTC_1078 idebenone 36.1 µM -0.139769230130877 0.445431887287341 no 1883 0.444421162704515 605 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_978 1416-0512 87.4 µM -0.140069175382251 0.445309106987876 no 1884 0.444302667471263 615 6814003
SGTC_2273 7815444 169.05 µM -0.140077533606181 0.445305685687772 no 1885 0.444299365574267 638 2824616
SGTC_2688 kanamycin b 96.69 µM -0.140330274279847 0.445202232417114 no 1886 0.4441995227837 612 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2357 9067248 200 µM -0.141084634690446 0.444893475480445 no 1887 0.443901540986438 635 9150235
SGTC_2391 6285546 200 µM -0.141148169214435 0.444867472557612 no 1888 0.443876445500416 594 846083
SGTC_2671 danthron 100 µM -0.141706024445948 0.444639168044624 no 1889 0.443656108073685 607 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_571 k831-0106 44.2 µM -0.141857907843035 0.444577012326744 no 1890 0.443596121335658 621 4783639
SGTC_1061 3448-9325 110 µM -0.142864556146264 0.444165093012284 no 1891 0.443198575735477 610 723482
SGTC_2568 diosmetin 100 µM -0.14369960513775 0.443823437678862 no 1892 0.442868841508694 599 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_786 4544-0069 423 µM -0.143877821905623 0.443750526744381 no 1893 0.442798474503657 605 748821 YLR208W SEC13
SGTC_707 0865-0008 204 µM -0.144875445066675 0.443342420597186 no 1894 0.44240460693568 603 723043
SGTC_1745 st081495 74 µM -0.14489976541272 0.44333247241602 no 1895 0.442395005827343 602 13842402 YBL026W LSM2
SGTC_1162 k048-0130 20.1 µM -0.145722497409835 0.442995956881436 no 1896 0.442070230292088 640 6797406
SGTC_3003 9075612 71.4286 µM -0.146151397158241 0.442820543711955 no 1897 0.441900936458088 643 6501993
SGTC_2369 9071472 200 µM -0.146414906987108 0.442712777942616 no 1898 0.441796930025175 613 17296037
SGTC_781 4335-2806 94.4 µM -0.147071789301768 0.442444155850968 no 1899 0.44153767829491 653 845254
SGTC_1184 1269-1718 139 µM -0.147675140745246 0.442197447709588 no 1900 0.441299575656432 603 5403821
SGTC_1202 1988-0068 29.6 µM -0.148039572614657 0.442048443738735 no 1901 0.441155768935651 613 2850480
SGTC_2703 st077852 53.4 µM -0.148213911750006 0.441977165210524 no 1902 0.441086976543771 632 6281836
SGTC_765 1319-0117 244 µM -0.148275305971808 0.441952064639709 no 1903 0.441062751451713 597 3487746 YGL099W LSG1
SGTC_1817 st052116 64.4 µM -0.148833393143655 0.441723905553145 no 1904 0.440842550085466 614 4361398
SGTC_432 NS 1619 61.3 µM -0.150193747774641 0.441167841920261 no 1905 0.440305879248323 612 4552 A K+/calcium channel activator.
SGTC_230 MPP+ 141.667 µM -0.1507628183032 0.440935260865941 no 1906 0.440081408820251 637 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1698 5-fluorocytosine 1.055 µM -0.151131114448813 0.440784747835764 no 1907 0.439936144304656 604 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_631 k072-0230 41.5 µM -0.151161831461258 0.440772194979988 no 1908 0.439924029169733 642 5773147
SGTC_1691 st019933 84.6 µM -0.151908533475739 0.440467065063855 no 1909 0.439629538834733 615 6176082
SGTC_2623 humulene 100 µM -0.152720000096945 0.440135510030803 no 1910 0.439309543993041 623 6187145 An anti-inflammatory.
SGTC_1877 wortmannin 25 µM -0.153548665659587 0.439796971045766 no 1911 0.438982807822276 627 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1257 0669-0121 16 µM -0.155663170453467 0.438933321598054 no 1912 0.438149264469257 609 4307855
SGTC_1540 guanosine 70.6 µM -0.155860114004815 0.438852896603744 no 1913 0.438071642711844 606 6802 Guanosine is a purine nucleoside
SGTC_3326 9140064 16.379 µM -0.155951944551246 0.43881539701972 no 1914 0.438035450168468 629 1868434
SGTC_2754 granisetron 64.02 µM -0.156057656097125 0.438772229721859 no 1915 0.437993787443769 638 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1060 3448-7350 82 µM -0.156760858121119 0.438485095814449 no 1916 0.437716661037208 638 570178
SGTC_1718 roemerine 11.9335 µM -0.156768736316297 0.438481879145379 no 1917 0.437713556475014 623 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2183 6420625 130.508 µM -0.157096115011276 0.438348213937625 no 1918 0.437584549669515 612 2897619
SGTC_2506 ethyl hematommate 54.16 µM -0.157390665040599 0.438227958331331 no 1919 0.437468484993343 621 3940691 An allergen.
SGTC_1770 st043884 66.3 µM -0.157995318570037 0.437981115004879 no 1920 0.437230243812016 612 670149
SGTC_2786 7743617 45.45 µM -0.160609270822864 0.436914275838568 no 1921 0.436200576318939 639 583674
SGTC_1876 myriocin 605 nM -0.160994853988217 0.436756945402102 no 1922 0.43604872684721 620 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2228 7354201 200 µM -0.161342495685002 0.4366151048895 no 1923 0.435911827476791 620 753451
SGTC_2332 7982454 138.89 µM -0.162686129025299 0.436066968825254 no 1924 0.435382784459635 629 2981748
SGTC_2070 5230947 200 µM -0.163888342228993 0.435576629228496 no 1925 0.434909522282321 658 2835538
SGTC_3080 9117754 49.47 µM -0.164556184555195 0.435304283060811 no 1926 0.434646660308546 614 9550191
SGTC_1065 prochlorperazine maleate 2.48 µM -0.164812482455111 0.435199772892222 no 1927 0.434545789412847 622 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.165269304500929 0.435013506554635 no 1928 0.434366009008785 620 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_884 0851-0618 334 µM -0.167069825382316 0.434279496221278 no 1929 0.433657554071685 658 9642473
SGTC_67 0335-0847 266 µM -0.167537810838584 0.434088751660209 no 1930 0.433473449597082 685 4552207 YOR254C SEC63
SGTC_3092 9117248 49.47 µM -0.16786332876521 0.433956083989596 no 1931 0.433345400052484 605 17141857
SGTC_3160 9100216 49.47 µM -0.168849901101098 0.433554043328232 no 1932 0.432957353194219 618 17191039
SGTC_252 miconazole 1.30953 nM -0.16947426764698 0.433299641583609 no 1933 0.432711805511631 636 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_322 k048-0136 19.3 µM -0.170010253195897 0.433081273225777 no 1934 0.432501036576888 614 6823282
SGTC_3295 9122362 53.5725 µM -0.170520990837433 0.432873210243909 no 1935 0.432300213902455 640 4730473
SGTC_201 4262-0159 12.803 µM -0.175648261678835 0.43078551638277 no 1936 0.430285142201813 636 1341029
SGTC_410 α-linolenic acid 100 µM -0.176305534908199 0.43051803003551 no 1937 0.430026956959373 634 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_153 4077-0274 519.67 µM -0.176596961060491 0.430399440362461 no 1938 0.429912490645389 608 3121976
SGTC_2123 5259487 200 µM -0.177331128831579 0.430100714255439 no 1939 0.42962415048896 616 2173474
SGTC_708 3448-5400 146 µM -0.17860702851399 0.429581657694089 no 1940 0.429123137640369 622 3462195
SGTC_376 3970-0862 59.1 µM -0.179405416011775 0.429256922637102 no 1941 0.428809689509983 665 3135186
SGTC_1354 1498-1681 81 µM -0.179891988361062 0.429059038317007 no 1942 0.428618682479999 644 5754243
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.180717076097228 0.428723523800864 no 1943 0.428294827343988 667 5282309
SGTC_3210 9128157 49.47 µM -0.181203234292696 0.428525856035585 no 1944 0.428104028014576 653 17590849
SGTC_180 1486-1293 102.781 µM -0.183356934542176 0.427650396237284 no 1945 0.427258982107781 661 4140536
SGTC_3291 9121177 71.43 µM -0.184410110945961 0.427222418865534 no 1946 0.426845869228842 641 17015612
SGTC_2264 7948757 110.76 µM -0.185418330426622 0.426812790783303 no 1947 0.426450466048102 613 2971411
SGTC_2670 beta-carotene 100 µM -0.185910924367986 0.426612684150256 no 1948 0.426257307573016 625 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_948 3448-0295 75.3 µM -0.186536653319993 0.426358521270632 no 1949 0.426011969022726 636 678569
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.187898762713488 0.425805356209642 no 1950 0.425478006337394 655 6708760
SGTC_2738 aclarubicin 5.55 µM -0.188202465187302 0.425682039726493 no 1951 0.425358970040325 634 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_677 0929-0063 136 µM -0.189042522839298 0.425340977484891 no 1952 0.425029744602117 617 1539583
SGTC_1834 st055981 52.8 µM -0.189127593218394 0.425306442139708 no 1953 0.424996407738835 666 471719 YDL150W RPC53
SGTC_1292 0kpi-0043 232 µM -0.189565343457615 0.42512874122477 no 1954 0.424824873320889 660 3333905
SGTC_3283 9109332 35.8195 µM -0.19006220906316 0.424927061371847 no 1955 0.424630191526858 624 17027281
SGTC_3014 9081533 49.47 µM -0.190099805854731 0.42491180147393 no 1956 0.424615461106196 668 21367265
SGTC_2222 6885208 172.143 µM -0.19020077312764 0.424870821132904 no 1957 0.424575902655847 614 609514
SGTC_536 3852-0578 10.6 µM -0.191174670965721 0.424475579694937 no 1958 0.424194373628916 639 2869208
SGTC_1969 st069479 40.1 µM -0.192349767536427 0.423998785963697 no 1959 0.423734118645334 631 3895485
SGTC_1934 st074720 32.6 µM -0.193699343604116 0.423451334690416 no 1960 0.423205652918991 618 17250992
SGTC_416 estradiol valerate 100 µM -0.194477197009336 0.423135867957874 no 1961 0.422901124505286 642 13791 A steroid.
SGTC_1965 Pectolinarigenin 58.4 µM -0.195400774066776 0.422761365447616 no 1962 0.422539605336684 629 5320438 An anti-inflammatory.
SGTC_2071 5230951 39.92 µM -0.195831087651195 0.422586900825398 no 1963 0.422371188366101 615 1799272
SGTC_2659 sanguinarine 24.21 µM -0.195968426127605 0.422531222056606 no 1964 0.42231743955121 636 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1470 k295-0292 231 µM -0.196125683486609 0.422467469819842 no 1965 0.42225589705481 619 5045612
SGTC_262 fenpropimorph 62.5 µM -0.198155523196713 0.421644754346003 no 1966 0.421461692382733 629 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2768 sulfasalazine 50.2 µM -0.19862855877873 0.421453077019555 no 1967 0.421276656018573 694 5384001 An antioxidant and salicylic acid derivative.
SGTC_1615 st002656 86.5 µM -0.199399493127376 0.421140728931557 no 1968 0.420975128473901 616 1584458
SGTC_271 rotenone 740 µM -0.201298781808083 0.420371434299989 no 1969 0.420232477523242 648 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1693 xanthone 101.9 µM -0.20206368921581 0.420061699210043 no 1970 0.419933467057913 654 7020 An insecticide.
SGTC_1269 0831-0796 3.05 µM -0.203078087632014 0.419651013741807 no 1971 0.419536999203024 637 927758
SGTC_3032 9089427 49.47 µM -0.203793137344382 0.419361573995955 no 1972 0.41925757795569 624 17173707
SGTC_329 k048-0121 21.3 µM -0.204274261354638 0.419166847868774 no 1973 0.419069591176524 642 6832902
SGTC_39 0986-0283 58.349 µM -0.204425097965693 0.419105803588487 no 1974 0.419010659468929 618 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1323 1348-1351 11.2 µM -0.204541039599979 0.419058882791717 no 1975 0.4189653624277 625 6989654
SGTC_1742 st038235 28.8875 µM -0.205178244719352 0.418801030747727 no 1976 0.418716433026669 635 564103 YBR002C RER2
SGTC_2237 6667747 47.222 µM -0.20531249197842 0.41874671056585 no 1977 0.418663992382013 658 729940 YDL015C TSC13
SGTC_2395 5646831 180.19 µM -0.205343338951257 0.418734229239919 no 1978 0.418651942916411 666 6808628
SGTC_1649 st011737 51.3 µM -0.205757701870226 0.418566577331062 no 1979 0.418490091592951 626 1761035
SGTC_2482 5981709 142.65 µM -0.205971609122884 0.418480035896459 no 1980 0.418406544216044 658 877755
SGTC_854 0422-0053 192 µM -0.206013293980193 0.418463171722519 no 1981 0.418390263473824 631 3596728
SGTC_2232 chlorophetanol 41.5365 µM -0.206161354816107 0.418403272916579 no 1982 0.418332436883156 645 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_398 bronopol 33.3 µM -0.207284925545288 0.417948788103223 no 1983 0.417893673081054 649 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_265 mycophenolic acid 32.932 µM -0.207699544017436 0.417781102404659 no 1984 0.417731786868088 659 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1048 3161-0300 24.5 µM -0.210281649291084 0.416737149483134 no 1985 0.416723928421205 623 2165101
SGTC_1280 0880-0253 10.1 µM -0.210806647964494 0.416524962501718 no 1986 0.416519075395893 667 6836607
SGTC_2285 7945142 200 µM -0.211550088496198 0.416224530214802 no 1987 0.416229025758537 661 2970608
SGTC_1911 st060208 74.3 µM -0.211570001579663 0.416216483796582 no 1988 0.41622125739432 638 688783
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.211830876815633 0.416111073369043 no 1989 0.416119489446916 635 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_642 0335-0876 158 µM -0.21420098818623 0.415153672799643 no 1990 0.415195162752585 618 6812350
SGTC_1324 1418-0026 34.4 µM -0.214578941979447 0.415001045720225 no 1991 0.415047806685861 668 1372513
SGTC_2437 5741531 144.16 µM -0.215714579827801 0.414542524368347 no 1992 0.414605117857505 643 2262990
SGTC_2662 daunorubicin 22.37 µM -0.215794866149024 0.414510112629993 no 1993 0.414573825131428 621 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1039 k821-0043 94 µM -0.21707647936549 0.413992801925223 no 1994 0.414074371836497 651 15992768
SGTC_1434 4073-0095 163 µM -0.218762073995607 0.413312655340179 no 1995 0.413417695915927 643 24133745
SGTC_1643 st009866 20.2 µM -0.218911843018412 0.413252235276774 no 1996 0.41335936041064 632 3156273 YOR207C RET1
SGTC_1570 verbenone 133 µM -0.220191532279253 0.412736064859916 no 1997 0.412860995534104 678 29025 A natural terpanoid with antifungal properties.
SGTC_400 oxethazaine 37.5 µM -0.220321675268249 0.412683579332968 no 1998 0.412810320227551 658 4621 A local anesthetic.
SGTC_2840 9008771 71.43 µM -0.221056582013023 0.412387227206892 no 1999 0.412524188236096 609 2992978
SGTC_738 1315-0003 72.4 µM -0.221194869106507 0.412331468329891 no 2000 0.412470352090947 691 6251474
SGTC_1907 st060210 83.7 µM -0.223305544190961 0.411480641171845 no 2001 0.411648856283688 663 688793
SGTC_1443 4112-3303 14 µM -0.224079769538534 0.411168649885635 no 2002 0.41134761690743 635 704433
SGTC_2699 st077704 54.6 µM -0.224142097170689 0.411143536023614 no 2003 0.411323368438641 650 645852
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.22427118714719 0.411091522565796 no 2004 0.411273147260632 660 521171
SGTC_2090 5301565 104.445 µM -0.224858926030101 0.4108547281981 no 2005 0.411044511655231 659 2056344
SGTC_1000 4048-0884 8.67 µM -0.225441779471064 0.41061993420673 no 2006 0.410817806368025 662 13040088
SGTC_1670 st016595 4.04 µM -0.225688570554414 0.410520527671599 no 2007 0.410721824067722 645 597879
SGTC_341 1486-1430 230 µM -0.225748881654126 0.410496235457558 no 2008 0.41069836861117 650 2054753 YPL210C SRP72
SGTC_1130 3454-2858 15.9 µM -0.226480562738929 0.410201555002121 no 2009 0.410413837598754 670 715628 YIL048W NEO1
SGTC_2201 6605497 169.863 µM -0.228152652809694 0.409528320668931 no 2010 0.409763784143407 670 670741
SGTC_1704 st028805 70.8 µM -0.230481764562215 0.408590994284942 no 2011 0.408858715931319 649 2876101
SGTC_2056 5235370 200 µM -0.231172359128096 0.408313172024123 no 2012 0.408590451333706 668 5511916
SGTC_1618 st003135 44.5 µM -0.233081500082429 0.407545375672143 no 2013 0.407849060056664 675 1270615
SGTC_3103 9120822 49.47 µM -0.233635520564699 0.407322632416556 no 2014 0.407633974687499 645 17141819
SGTC_2813 7971799 71.43 µM -0.23402949066801 0.407164255445589 no 2015 0.40748104203162 670 2234054
SGTC_3041 9091929 49.47 µM -0.234504918179489 0.406973152602903 no 2016 0.407296507737946 646 25236887
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.23460845734838 0.406931536933676 no 2017 0.407256322366662 665 4174840
SGTC_1017 4239-0030 168 µM -0.234626594170101 0.406924247279097 no 2018 0.407249283247832 630 1149593
SGTC_3078 9116413 49.47 µM -0.234944361454348 0.40679653367803 no 2019 0.407125958801593 634 17177322
SGTC_945 3381-0768 11.3 µM -0.23548470230546 0.406579388471548 no 2020 0.406916275424778 674 1126236 YIL048W NEO1
SGTC_2518 prenyletin 46.28 µM -0.237275556815236 0.405859908683205 no 2021 0.406221511770117 631 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_587 k089-0003 57 µM -0.238138294635446 0.405513415140761 no 2022 0.405886917056024 646 9659696
SGTC_2139 5578692 56.4705 µM -0.240326390833727 0.404634962525069 no 2023 0.405038618749325 650 650991 YMR113W FOL3
SGTC_60 0986-0278 202 µM -0.24140582199597 0.404201781157144 no 2024 0.404620300435022 670 3110598
SGTC_392 N-ethylmaleimide 8.33 µM -0.241489765168727 0.404168099237535 no 2025 0.404587774004583 638 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_185 k048-0037 25.491 µM -0.242017442815582 0.403956386610225 no 2026 0.404383323762006 640 6827589
SGTC_24 0417-1663 219 µM -0.243720349678791 0.403273345590577 no 2027 0.403723705885709 682 4329390
SGTC_475 α-linolenic acid 10 µM -0.243828196644582 0.403230097761994 no 2028 0.403681940756703 678 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_650 1328-0195 38 µM -0.24441498136504 0.402994811337615 no 2029 0.403454720058176 667 2780821
SGTC_2250 alverine citrate 130 µM -0.244418340279012 0.40299346459569 no 2030 0.403453419479353 636 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1959 st077091 55.8 µM -0.245034317991444 0.402746510487177 no 2031 0.403214929630823 653 821356 YKL052C ASK1
SGTC_693 4161-2696 114 µM -0.245339614086868 0.40262412737192 no 2032 0.403096740605849 652 805759
SGTC_1230 0170-0365 3.77 µM -0.245685362752169 0.402485539680746 no 2033 0.402962901900787 660 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3076 9116187 49.47 µM -0.246008005789128 0.40235622455544 no 2034 0.402838017598123 683 27241210
SGTC_3218 9131285 49.47 µM -0.246112677148415 0.402314274635596 no 2035 0.402797504952997 688 17156417
SGTC_1351 1496-0003 46.5 µM -0.246214704225711 0.40227338556707 no 2036 0.402758016771409 645 3891978
SGTC_3275 9138069 49.47 µM -0.246463132036809 0.402173828412917 no 2037 0.402661870341797 639 17617007
SGTC_1285 0929-0069 65.5 µM -0.246817083313882 0.402031993816828 no 2038 0.40252489443346 643 1206237
SGTC_2175 5807670 165.306 µM -0.247167670792868 0.40189151987136 no 2039 0.402389232080003 642 241186
SGTC_1355 1499-0035 1.68 µM -0.248441378732459 0.401381275349194 no 2040 0.401896460655195 662 1548538
SGTC_2584 androsterone 48.74 µM -0.2503899226285 0.400601018661992 no 2041 0.401142911020808 670 2754130 A steroid.
SGTC_2826 7992541 19.48 µM -0.25100389715774 0.40035524643847 no 2042 0.400905548065718 684 2985066
SGTC_444 curcumin 90.4 µM -0.25103013234889 0.400344745445765 no 2043 0.400895406337908 659 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_26 0302-0163 425.158 µM -0.251106513718654 0.400314173172051 no 2044 0.400865880001333 685 3100915
SGTC_2179 6298986 200 µM -0.251371545726148 0.400208096661302 no 2045 0.400763432391871 662 738374
SGTC_3205 9113483 49.47 µM -0.251382063142042 0.400203887318607 no 2046 0.400759367045865 695 17018033
SGTC_847 0342-0274 5.54 µM -0.253855783067767 0.399214163476578 no 2047 0.399803487977598 670 18097
SGTC_1988 st071872 53.4 µM -0.254812000868835 0.398831758346572 no 2048 0.399434152908132 652 16414116
SGTC_610 4215-0184 155 µM -0.256737529381651 0.398062007003798 no 2049 0.398690699039069 666 5605015
SGTC_3260 9137109 49.47 µM -0.257957590441734 0.397574479141306 no 2050 0.398219818838088 677 17478346
SGTC_2409 alverine citrate 63.97 µM -0.258189010811551 0.397482023203811 no 2051 0.398130519293332 643 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2789 5281112 71.43 µM -0.258440923086298 0.39738138698716 no 2052 0.398033318481455 668 765948
SGTC_12 0849-0099 9.267 µM -0.258737093884895 0.39726307870764 no 2053 0.397919048530961 641 6071388
SGTC_2127 5253358 187.912 µM -0.259293517363997 0.397040835554657 no 2054 0.397704390405614 668 20612
SGTC_545 4218-0007 221 µM -0.260513301122925 0.396553754292595 no 2055 0.397233928310328 684 2840508
SGTC_1564 D-Arginine 115 µM -0.262096155356493 0.395921933245723 no 2056 0.396623655393177 707 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_260 nsc-65238 3.989 µM -0.264133404167952 0.395109135998591 no 2057 0.395838562405062 658 3246252
SGTC_2594 a-mangostin 100 µM -0.266400611470864 0.394205129087386 no 2058 0.394965347176022 687 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_732 3970-1727 52.7 µM -0.266515313032735 0.394159409062066 no 2059 0.394921183829338 686 1275699
SGTC_563 tetrahydrosecaminediol 614 µM -0.267243698165001 0.393869108919088 no 2060 0.394640766474285 674 334274 A psychoactive constituent of the cannabis plant.
SGTC_503 tyrphostin 8 294 µM -0.26773230180801 0.393674407462719 no 2061 0.394452691974967 705 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_873 0591-4978 488 µM -0.26850822668065 0.393365267306475 no 2062 0.394154071662833 681 3305145
SGTC_1739 st037196 92.5 µM -0.269353168622206 0.393028706165041 no 2063 0.393828960391876 689 612214
SGTC_1332 1480-0653 17.5 µM -0.269721829796549 0.392881884394085 no 2064 0.393687132509666 689 5749438
SGTC_813 k007-0158 173 µM -0.269798229851619 0.392851459468272 no 2065 0.393657742357829 648 6523916
SGTC_411 enrofloxacin 100 µM -0.271246351461123 0.39227489549793 no 2066 0.393100782713859 679 71188 A bacterial gyrase inhibitor.
SGTC_2308 7584454 197.62 µM -0.271247728705198 0.3922743472659 no 2067 0.393100253118245 694 893577
SGTC_903 1134-0042 114 µM -0.271279183482042 0.392261826292813 no 2068 0.393088157776558 653 701009
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.271587702036304 0.392139022481472 no 2069 0.392969528252793 690 23847180
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.273495557216296 0.391379852148718 no 2070 0.392236153519105 676 4620898
SGTC_1034 k072-0165 12.7 µM -0.273971080325094 0.39119069711538 no 2071 0.392053423095279 703 5835461
SGTC_2336 9001819 198.65 µM -0.273987081267814 0.391184332658827 no 2072 0.392047274787789 681 2989602
SGTC_2828 7998861 71.43 µM -0.274417132327281 0.391013288577822 no 2073 0.391882039241932 658 2988188
SGTC_1247 0448-0043 5.84 µM -0.274640806423994 0.390924335076174 no 2074 0.391796106196256 697 3089013 YGL099W LSG1
SGTC_3001 9076041 71.4286 µM -0.275545659475219 0.39056454012453 no 2075 0.391448525850867 673 16004211
SGTC_648 0375-0473 33.3 µM -0.275549075675865 0.390563181924668 no 2076 0.391447213752972 675 1713139
SGTC_3242 9133940 49.47 µM -0.276537017691169 0.390170455848558 no 2077 0.391067815840814 690 17248444
SGTC_573 3702-0553 84.7 µM -0.277923430095799 0.389619519132597 no 2078 0.390535568780797 674 1222756
SGTC_2787 5284540 71.43 µM -0.278736363576039 0.389296576245743 no 2079 0.390223576963225 695 736958
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.278834216481928 0.389257708720031 no 2080 0.39018602723133 660 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3305 9127027 53.8275 µM -0.279937366609355 0.388819610266889 no 2081 0.38976277921762 676 41905295
SGTC_922 1866-0035 480 µM -0.281423392738149 0.388229682260505 no 2082 0.389192839012119 687 3156169
SGTC_323 4013-0906 34.3 µM -0.2822431145401 0.387904376375613 no 2083 0.388878550476766 679 2910086
SGTC_1569 carminic acid 40.6 µM -0.28336011325835 0.387461223052605 no 2084 0.388450400437095 645 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_166 k072-0058 166.424 µM -0.283826342163746 0.387276296707879 no 2085 0.388271733099805 676 5846229
SGTC_1383 3049-0032 20.7 µM -0.284402507988398 0.38704780001344 no 2086 0.38805096861358 697 712864
SGTC_1873 rapamycin 2 nM -0.285708814576521 0.386529888085775 no 2087 0.387550576472956 664 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_91 0417-1751 58.384 µM -0.286834209627731 0.386083864210195 no 2088 0.387119633771221 677 6795624
SGTC_2948 9070189 9.45 µM -0.290022110942755 0.384821233344672 no 2089 0.385899661070465 688 6473636 YDL196W YDL196W
SGTC_1486 3970-0793 4.53 µM -0.290756766823502 0.384530431029599 no 2090 0.385618676254204 680 2844330
SGTC_2692 st077426 47.7 µM -0.291111904719695 0.384389878397745 no 2091 0.38548286769758 717 25238571
SGTC_1357 1503-1303 39.5 µM -0.291713137227736 0.384151963758424 no 2092 0.385252981923146 664 292895
SGTC_1437 4092-1038 11.6 µM -0.291872767479049 0.384088803555105 no 2093 0.385191952864993 677 3977136
SGTC_1046 2001-0062 216 µM -0.292495674248452 0.383842370214159 no 2094 0.384953833399804 679 739778
SGTC_2872 9044037 25.97 µM -0.292859650242379 0.383698396369068 no 2095 0.384814715848374 661 6465195
SGTC_1781 st038725 66.3 µM -0.293634936018662 0.383391778930342 no 2096 0.384518438453177 658 4270275 YIL048W NEO1
SGTC_2130 NSC 7 2.4545 µM -0.29439363533889 0.383091791952233 no 2097 0.384228564903826 684 21448
SGTC_1848 st056003 16.4 µM -0.294496189633905 0.38305124772754 no 2098 0.384189387312678 648 146492
SGTC_2241 6772625 37.8075 µM -0.294806482559227 0.382928583086923 no 2099 0.384070857023841 640 2285411
SGTC_2935 9038016 29.96 µM -0.294875183218969 0.382901426008507 no 2100 0.384044615193627 691 6463195
SGTC_694 1315-0438 43.2 µM -0.295245288085448 0.382755135036456 no 2101 0.383903254097992 703 6793154
SGTC_468 gf-109203x 121 µM -0.296936138906221 0.382087007208463 no 2102 0.383257632462718 681 2396 A protein kinase C inhibitor.
SGTC_2589 lobaric acid 100 µM -0.297209747883641 0.381978925483661 no 2103 0.383153190107497 680 73157 A novel microtubule depolymerizer.
SGTC_2305 7443522 69.23 µM -0.299644421901703 0.381017580241468 no 2104 0.382224198195742 675 5415886
SGTC_1465 k213-0056 144 µM -0.300341838379832 0.380742336243593 no 2105 0.381958211505407 664 24048857 YMR208W ERG12
SGTC_405 ebelactone b 50 µM -0.302251486911766 0.379988979168841 no 2106 0.381230178795343 670 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_759 3486-0358 89.3 µM -0.302510508804766 0.379886829926104 no 2107 0.381131461820349 693 875103
SGTC_490 phenamil 164 µM -0.302803023699297 0.379771482281808 no 2108 0.38101998948002 680 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2558 carylophyllene oxide 100 µM -0.304795094619013 0.378986232243176 no 2109 0.380261108903131 698 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2914 7968218 45.32 µM -0.308030591036378 0.377711904055027 no 2110 0.379029527515429 705 2977111
SGTC_3083 9117465 49.47 µM -0.308558351247398 0.377504166926827 no 2111 0.378828753344124 729 16420915
SGTC_2208 7283366 200 µM -0.308589970447658 0.377491722092448 no 2112 0.378816725587875 675 898663
SGTC_2299 7976368 114.88 µM -0.30951132753818 0.377129145914251 no 2113 0.378466298393864 687 2979718
SGTC_450 aminopyrene 156 nM -0.310566202433835 0.376714160262048 no 2114 0.378065211994624 691 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_74 000s-0487 160.283 µM -0.311230379717193 0.37645294729162 no 2115 0.377812744707761 680 677548
SGTC_1804 st050076 49.1 µM -0.311543660879453 0.376329757189094 no 2116 0.377693678275195 672 3895976
SGTC_1995 st072814 61.1 µM -0.3122200024505 0.376063845489708 no 2117 0.377436665821373 673 5769371
SGTC_3316 9136639 10.545 µM -0.312455660744316 0.375971207454228 no 2118 0.377347127486836 708 4903665
SGTC_3019 9081971 49.47 µM -0.312460781346598 0.375969194608271 no 2119 0.377345181987909 702 16451803
SGTC_2382 9035899 200 µM -0.312518889323867 0.375946353311485 no 2120 0.377323104918757 714 6462679
SGTC_221 trifluoperazine 10.304 µM -0.313114171496759 0.375712382657915 no 2121 0.377096961386558 687 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2908 7930301 100 µM -0.313241382057044 0.375662389539476 no 2122 0.377048640448117 697 2223178
SGTC_640 3381-0960 37.1 µM -0.314587445649816 0.375133521289027 no 2123 0.376537456233271 689 1745025
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.315238339299785 0.374877869346532 no 2124 0.376290348934388 698 688667
SGTC_937 3122-0005 46.7 µM -0.31583529098736 0.374643452548142 no 2125 0.376063764898077 681 759535
SGTC_2289 7946404 165.07 µM -0.316295092625324 0.374462924739057 no 2126 0.375889267814096 675 1246120 YPR165W RHO1
SGTC_1216 1165-0504 9.65 µM -0.316852837488397 0.37424397929186 no 2127 0.375677634835644 694 6304004
SGTC_2940 9060638 45.86 µM -0.316881862409931 0.374232586527851 no 2128 0.375666622524606 687 4027022
SGTC_2745 rifampicin 24.3 µM -0.318110065548694 0.373750597158113 no 2129 0.375200724357754 670 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2140 5586273 200 µM -0.318291787528043 0.373679299915385 no 2130 0.3751318066271 667 854421
SGTC_2718 lomofungin 53.02 µM -0.318420385487345 0.373628848091513 no 2131 0.375083038492972 702 5351222 A RNA synthesis inhibitor.
SGTC_1567 st069303 68.4 µM -0.320138276928308 0.372955089291797 no 2132 0.3744317552595 704 5581319
SGTC_112 phenothiazine 287.218 µM -0.322923444286865 0.371863569853725 no 2133 0.37337661036923 725 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_79 0052-0007 94.094 µM -0.323106213308974 0.3717919777518 no 2134 0.373307402445759 676 2801472
SGTC_194 1486-1323 56.904 µM -0.323558653089307 0.371614772511632 no 2135 0.373136097684444 670 5178754
SGTC_2306 7482397 179.52 µM -0.324950410751694 0.37106983916052 no 2136 0.372609301552936 728 891448
SGTC_579 4491-1009 110 µM -0.325143310117808 0.37099433107807 no 2137 0.372536305719121 698 1271041
SGTC_273 hydroxyurea 18.1 mM -0.326887866103246 0.370311672016524 no 2138 0.371876349416771 686 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1671 st016596 74.5 µM -0.327343526306015 0.3701334355989 no 2139 0.371704037469323 669 2829167
SGTC_3091 9116372 49.47 µM -0.32757539588468 0.37004274800757 no 2140 0.371616363795651 696 17169793
SGTC_2294 7971431 200 µM -0.327849952494458 0.369935374235765 no 2141 0.371512558069549 730 5741572
SGTC_692 k241-0027 77.8 µM -0.328666457722604 0.36961611479286 no 2142 0.371203904957086 713 3600480
SGTC_2605 digitonin 300 nM -0.329212383647446 0.369402703929019 no 2143 0.370997581692942 696 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2429 5902844 64.44 µM -0.329556344711082 0.369268264901055 no 2144 0.37086760659256 700 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_588 3970-1144 52.9 µM -0.330246670845805 0.368998495481094 no 2145 0.370606792440758 682 1888707
SGTC_116 0155-0182 31.788 µM -0.331622301989073 0.368461111324764 no 2146 0.370087238572588 701 771486
SGTC_2367 9070478 135.38 µM -0.332200897099207 0.368235162504545 no 2147 0.369868783201855 661 572802
SGTC_593 1203-0218 61.7 µM -0.332246125778403 0.368217502043765 no 2148 0.369851708351917 713 3666956
SGTC_1410 3909-8106 77.9 µM -0.332912555300057 0.36795731333586 no 2149 0.36960014588615 698 1039210
SGTC_3011 9081274 71.4286 µM -0.334321769216159 0.367407324886229 no 2150 0.369068382562827 677 6625322
SGTC_3093 9117344 49.47 µM -0.334885634790586 0.367187335347296 no 2151 0.368855679416119 671 24824913
SGTC_2258 7960471 200 µM -0.335527296026948 0.366937047223868 no 2152 0.368613678803038 728 2974708
SGTC_491 tetrandrine 80.3 µM -0.33718601034201 0.366290306884102 no 2153 0.367988341281569 709 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3167 9103034 49.47 µM -0.337306527953112 0.366243331283934 no 2154 0.367942919587416 681 5127859
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.339580574649095 0.365357325180907 no 2155 0.367086204451826 743 688798
SGTC_1960 st011366 51.8 µM -0.339805261179786 0.365269822506316 no 2156 0.367001592793739 676 3972846
SGTC_619 1652-1634 108 µM -0.340219693764361 0.365108442894843 no 2157 0.366845544187584 706 5400454
SGTC_1555 citronellol 128 µM -0.340744456890396 0.364904134962236 no 2158 0.36664798377835 708 8842 A terpine precursor.
SGTC_1679 SEC14.276 6.7 µM -0.341249790608575 0.364707427798515 no 2159 0.366457771447821 677 1005053 YMR079W SEC14
SGTC_2430 5571206 200 µM -0.343379488541781 0.363878809387549 no 2160 0.365656494149779 709 1731771
SGTC_2920 7982904 15.77 µM -0.345772563901466 0.362948475725214 no 2161 0.364756822811699 713 6456808
SGTC_1211 1056-0033 32.3 µM -0.346613550722713 0.362621724738184 no 2162 0.36444083216506 713 6741922
SGTC_757 1066-0008 322 µM -0.347891554349354 0.362125369936594 no 2163 0.36396081411283 698 6842497
SGTC_533 1222-0222 6.71 µM -0.34863342631714 0.361837345781971 no 2164 0.363682264901901 724 3982874
SGTC_3060 1327-0027 12.5 µM -0.348841691183152 0.361756503150242 no 2165 0.363604081045475 693 16000455 YPR107C YTH1
SGTC_1835 st008666 49.2 µM -0.349311796712384 0.361574043936096 no 2166 0.363427621548364 697 690455
SGTC_3307 9126885 69.2785 µM -0.349841351250081 0.361368548832528 no 2167 0.363228881888922 701 24824909
SGTC_1147 3809-1045 12.3 µM -0.35136331347794 0.360778169984101 no 2168 0.362657900791316 681 325925
SGTC_2953 9074162 66.49 µM -0.352383429981807 0.360382645821401 no 2169 0.362275363511086 680 16451992
SGTC_662 k832-1615 104 µM -0.353268686690737 0.360039531132855 no 2170 0.361943509218768 709 5878478
SGTC_2374 9071832 200 µM -0.354708084840404 0.359481878755869 no 2171 0.361404146735142 720 17381698
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.356722600132661 0.358701916673062 no 2172 0.360649742373918 746 65057 A dermal irritant. YDR527W RBA50
SGTC_2370 9071495 200 µM -0.357756681083598 0.358301778935861 no 2173 0.360262705608876 734 21791103
SGTC_1019 4262-0212 3.4 µM -0.360344605990023 0.357301063732535 no 2174 0.359294722942444 711 4677213
SGTC_1118 chelidonine 707.474 nM -0.360487241922164 0.357245936817867 no 2175 0.359241397844466 726 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_459 nigericin 15.3 µM -0.360957488253627 0.357064213894948 no 2176 0.359065613520189 750 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_970 1315-0089 19.5 µM -0.362396698235692 0.356508244356878 no 2177 0.358527803244609 684 6811083 YLR033W RSC58
SGTC_1499 4480-0877 67.3 µM -0.362708363056944 0.35638788775378 no 2178 0.358411375878228 699 2861909
SGTC_2895 9054447 58.44 µM -0.363214699975344 0.356192384500426 no 2179 0.358222253706934 697 2697450
SGTC_513 4245-1575 41.7 µM -0.36522276425084 0.355417417459844 no 2180 0.357472563421365 685 719745
SGTC_3214 9129694 49.47 µM -0.365549072293199 0.355291542588079 no 2181 0.357350791490172 731 17158655
SGTC_2756 carbadox 75.1 µM -0.365847042689302 0.355176612886367 no 2182 0.357239607314276 695 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2290 7904846 200 µM -0.36621268008982 0.355035601449293 no 2183 0.357103190546929 694 2962154
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.366297912744324 0.355002733542278 no 2184 0.357071393461746 737 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2260 7964312 200 µM -0.367002764645232 0.354730965870304 no 2185 0.356808477899493 713 231951
SGTC_3272 9137413 49.47 µM -0.367442470773197 0.354561467102562 no 2186 0.356644498329454 733 17614870
SGTC_2098 5376439 882.5 nM -0.368311478564888 0.354226565018281 no 2187 0.356320497266393 698 2844116
SGTC_2777 climbazole 1.536 µM -0.368405124362417 0.354190482107524 no 2188 0.356285588530814 709 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3101 9120531 49.47 µM -0.368694949319772 0.354078817180555 no 2189 0.356177556901922 761 24824904
SGTC_2453 5731132 22.18 µM -0.368896304313158 0.354001245704004 no 2190 0.356102509056831 740 1362040
SGTC_1609 st001574 46.4 µM -0.370327287506781 0.353450137944301 no 2191 0.355569322173402 722 3960012
SGTC_3198 9112019 49.47 µM -0.370548150282555 0.35336510544117 no 2192 0.3554870534505 754 45595555
SGTC_1987 st072290 61.9 µM -0.370658848757258 0.353322489113947 no 2193 0.35544582213509 723 54697379
SGTC_1701 st028638 40.4 µM -0.372252641949719 0.352709120046194 no 2194 0.354852377573815 716 3490878
SGTC_829 1635-0120 117 µM -0.372560512372702 0.352590680599873 no 2195 0.354737783381641 718 285054
SGTC_875 0709-0210 25.7 µM -0.373012336093961 0.352416887402336 no 2196 0.354569631318632 736 6251364
SGTC_2588 indole-3-carbinol 100 µM -0.373197248281967 0.352345770137476 no 2197 0.354500822017577 732 3712 Induces cell cycle arrest.
SGTC_2959 9079155 11 µM -0.374321654319487 0.351913434561906 no 2198 0.354082511690511 739 16189457
SGTC_2523 spermine 47.74 µM -0.375386754949759 0.351504078485623 no 2199 0.353686426961308 707 1103 A DNA binding polyamine.
SGTC_1319 1306-0155 43.7 µM -0.375406271149199 0.351496579320401 no 2200 0.353679170842714 688 3122360
SGTC_1996 st072960 66.8 µM -0.375841910623239 0.35132919843841 no 2201 0.3535172140257 677 1719405
SGTC_941 3237-0776 460 µM -0.376474186647102 0.351086317387254 no 2202 0.353282201207277 720 760008
SGTC_2616 abietic acid 100 µM -0.377333815199069 0.350756199229827 no 2203 0.35296277269276 729 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_334 1502-1024 68.5 µM -0.378107234973562 0.350459283584712 no 2204 0.352675466938367 736 3296216
SGTC_1082 camptothecin 424.86 nM -0.378256417296325 0.350402023034483 no 2205 0.352620059163759 700 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2773 thioridazine 9.09 µM -0.380368247255802 0.349591806008646 no 2206 0.35183604074376 717 5452 An antipsychotic.
SGTC_2892 9047358 58.44 µM -0.381365727394909 0.349209354224439 no 2207 0.351465944223113 738 6466771
SGTC_1281 0884-0031 11.8 µM -0.381924190272867 0.348995296354235 no 2208 0.351258798366327 692 1548255
SGTC_1603 st002045 67.8 µM -0.382276305626264 0.34886035582974 no 2209 0.351128213936023 722 5887985
SGTC_425 3825-7017 13.1 µM -0.382709574494997 0.348694341222642 no 2210 0.350967557280283 729 3397440
SGTC_1767 st044992 70.3 µM -0.383092185689581 0.348547761081418 no 2211 0.350825706702362 725 9600693
SGTC_489 paxilline 115 µM -0.383923559831095 0.348229335718991 no 2212 0.350517551912261 739 105008 A toxic potassium channel blocker.
SGTC_2235 salicylic acid 500 µM -0.38529157966119 0.34770560208681 no 2213 0.350010699681644 712 338 A COX inhibitor and kinase inhibitor.
SGTC_1886 st057356 49.9 µM -0.386456356489343 0.347259907057804 no 2214 0.349579359595086 691 24207747
SGTC_1016 4226-1401 38 µM -0.388498830260633 0.346478876472603 no 2215 0.348823459769497 719 2901613
SGTC_3117 9124945 49.47 µM -0.389723214097612 0.346010991371861 no 2216 0.348370614396969 703 17592065
SGTC_3225 9130819 49.47 µM -0.391346522036274 0.345391024127568 no 2217 0.347770557837889 754 4547121
SGTC_2036 5160441 105 µM -0.391409099651406 0.345367133024789 no 2218 0.347747433612187 708 134534 YIL048W NEO1
SGTC_1892 st058411 7.36 µM -0.39379900405796 0.344455168742652 no 2219 0.346864719886477 730 3934738
SGTC_772 k072-0172 35.3 µM -0.39438934936603 0.34423003765808 no 2220 0.346646802947115 694 5861980
SGTC_1344 1488-0097 29.1 µM -0.394405290446852 0.344223959213493 no 2221 0.346640919244145 723 747966
SGTC_218 alverine citrate 93.75 µM -0.394507026785615 0.34418516739052 no 2222 0.346603370190009 728 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2933 9026794 32.47 µM -0.394580110376793 0.34415730180362 no 2223 0.346576397280157 733 17586027
SGTC_1883 5-benzylidenerhodanine 20 µM -0.395014231059085 0.343991796080684 no 2224 0.34641619270033 721 1273210
SGTC_1545 lovastatin 49.4 µM -0.395057807304138 0.34397518456699 no 2225 0.346400113172458 700 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.395117221447366 0.34395253604119 no 2226 0.346378189944893 711 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_814 3342-0569 96 µM -0.396965929887776 0.343248093021383 no 2227 0.345696292402244 714 4346283
SGTC_1516 st013856 110 µM -0.397841507208985 0.342914647541746 no 2228 0.34537350947462 724 5281404 A mutagen and neurotoxin.
SGTC_1812 st052057 4.327 µM -0.398793732738578 0.342552151024884 no 2229 0.345022597685306 712 3645418
SGTC_119 0121-0043 24.815 µM -0.399056462226674 0.342452159754354 no 2230 0.344925800706013 742 1092378
SGTC_3061 glucosamine 200 µM -0.399537996389022 0.342268923067351 no 2231 0.344748416240482 719 91431 and experimental redox chemotherapeutic
SGTC_3133 9127736 49.47 µM -0.399638836318857 0.342230555464917 no 2232 0.344711273794147 718 27243420
SGTC_1741 st038134 10.228 µM -0.3997982637073 0.342169899813959 no 2233 0.344652554839607 739 1272587
SGTC_1407 3909-7909 12.3 µM -0.401829758544345 0.341397355476487 no 2234 0.343904659864368 707 4411780
SGTC_2569 tetrandrine 100 µM -0.403083347129244 0.340920967311162 no 2235 0.343443455450566 700 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1390 3413-2614 145 µM -0.404367009463554 0.340433413251128 no 2236 0.342971428128479 748 3421432
SGTC_1822 st052468 42 µM -0.404657031971271 0.340323295274025 no 2237 0.342864815176062 706 2873678
SGTC_90 0870-0863 4.608 µM -0.404914319765512 0.340225617660514 no 2238 0.342770246053471 739 1738164
SGTC_1013 4112-3890 241 µM -0.405372544200772 0.34005168232848 no 2239 0.34260184473071 719 705171
SGTC_2691 st077356 60.2 µM -0.405992663831028 0.339816348138504 no 2240 0.342373995377906 733 2839272
SGTC_2536 dehydroabietamide 32.04 µM -0.407072823644744 0.33940657868872 no 2241 0.341977251362526 719 3983547
SGTC_716 1683-5115 658 µM -0.408186994401065 0.338984105706685 no 2242 0.341568197826176 749 723597
SGTC_2698 st077697 67.5 µM -0.408717914058847 0.338782861948843 no 2243 0.341373342871521 723 3154499
SGTC_2866 9034245 58.44 µM -0.412702527583618 0.337273976149599 no 2244 0.339912286378855 713 6462273
SGTC_1079 idarubicin 2.36 µM -0.413310954692937 0.337043807550409 no 2245 0.339689402416542 741 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2441 5730946 39.09 µM -0.414236266696625 0.336693878012371 no 2246 0.339350542051939 696 1774275
SGTC_2360 9040895 200 µM -0.415465631656888 0.336229182031729 no 2247 0.338900534762126 719 4914414
SGTC_2664 lyso-paf C-16 73.48 µM -0.417049004520119 0.335631040796511 no 2248 0.338321282031541 734 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1450 4112-4260 37.6 µM -0.418510534284788 0.335079296856575 no 2249 0.337786943081424 725 1633175
SGTC_1720 st037298 9.481 µM -0.41881201808335 0.334965527542332 no 2250 0.337676760468127 772 597396
SGTC_3232 9132874 49.47 µM -0.419272108628304 0.334791934846082 no 2251 0.33750863901709 735 3784940
SGTC_1638 st008370 60.6 µM -0.420024360212131 0.334508185501577 no 2252 0.33723382901758 704 24207134
SGTC_1183 1254-0324 198 µM -0.4219761828079 0.33377239893874 no 2253 0.336521200977468 713 5799357
SGTC_1070 indatraline 8.81 µM -0.422290085535402 0.333654125291737 no 2254 0.336406646966323 743 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2622 2-methoxyxanthone 59.94 µM -0.422306872750091 0.333647800596844 no 2255 0.336400521156092 726 71034 A hepatoprotective.
SGTC_1976 st070609 63.5 µM -0.422522781884298 0.333566459607671 no 2256 0.336321737783551 717 682556
SGTC_174 3553-0389 74.3 µM -0.422935227584579 0.333411097744465 no 2257 0.336171259900536 704 738071
SGTC_2760 etidronate 98.04 µM -0.423115835543466 0.333343074536534 no 2258 0.336105374631945 720 3305 A chelator and antioxidant.
SGTC_423 5-fluorouracil 457 µM -0.423154797822925 0.333328400712276 no 2259 0.336091161963607 721 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1736 st036774 51 µM -0.423411433897881 0.333231753792359 no 2260 0.335997552058933 764 1272247
SGTC_1940 st075990 51.1 µM -0.425269728464777 0.332532266878662 no 2261 0.335320029173799 743 1084979
SGTC_3183 9108214 49.47 µM -0.425698970509731 0.332370777194526 no 2262 0.335163606160388 734 4974831
SGTC_1033 k072-0102 21.3 µM -0.427735213554956 0.331605125007401 no 2263 0.334421954752859 766 5965931
SGTC_3314 9135860 59.4275 µM -0.427822814929509 0.331572201574603 no 2264 0.334390062576864 742 25252478
SGTC_1829 berberine 14.4 µM -0.430681002686129 0.3304987171615 no 2265 0.333350166937888 739 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_31 0508-1974 57.237 µM -0.430772490023764 0.330464379110765 no 2266 0.333316902154625 711 6810525
SGTC_2891 9063876 19.48 µM -0.43290588441096 0.32966405488938 no 2267 0.332541572445525 739 6472478
SGTC_1978 st071761 42 µM -0.434795139455568 0.328955967901097 no 2268 0.331855566642591 705 5147680
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.434883370365593 0.328922914199732 no 2269 0.331823542943249 739 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_668 1682-0499 62.6 µM -0.436873702182209 0.328177637611862 no 2270 0.331101472334804 735 682214
SGTC_1769 st044406 64.4 µM -0.437533236751631 0.327930826548651 no 2271 0.330862338731907 752 670903
SGTC_288 1315-0019 35.1 µM -0.43760827161453 0.327902751756057 no 2272 0.330835137011316 732 6811474
SGTC_2093 5331342 194.4 µM -0.438362263800147 0.32762069457776 no 2273 0.330561848541216 735 33839
SGTC_1938 st074717 56.4 µM -0.438518088816639 0.327562415031062 no 2274 0.330505380193689 714 17250979
SGTC_319 1348-1596 45.5 µM -0.438884783007617 0.327425285651043 no 2275 0.330372511653346 754 5380505
SGTC_2909 7941780 10.49 µM -0.439076602830421 0.327353561763951 no 2276 0.330303015879015 739 1243215
SGTC_2304 7443016 91.4 µM -0.439479199325469 0.32720304650856 no 2277 0.330157175353821 744 939854
SGTC_250 brefeldin a 552.239 µM -0.440127042840782 0.326960901866879 no 2278 0.329922548302345 725 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2771 fluoxetine 41.05 µM -0.440154179963435 0.326950760406156 no 2279 0.329912721611708 751 3386 A selective serotonin reuptake inhibitor.
SGTC_109 0132-0036 33.701 µM -0.441810895062599 0.326331868875765 no 2280 0.329313026942894 703 67274 A color developer.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.442847359704541 0.325944924359435 no 2281 0.328938072429617 714 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2045 5106652 78.05 µM -0.442911915360655 0.325920829917994 no 2282 0.328914724273422 735 673349
SGTC_3240 9133527 49.47 µM -0.443703239344261 0.325625539069909 no 2283 0.328628576572862 769 17617455
SGTC_2812 7970281 58.44 µM -0.444622260624794 0.325282733933652 no 2284 0.328296378816732 751 2233435
SGTC_2234 tolnaftate 200 µM -0.445450396979545 0.324973956461271 no 2285 0.327997149388582 737 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2318 6029776 164 µM -0.446698958098489 0.324508647391758 no 2286 0.327546217110747 772 818325
SGTC_1665 st014639 11.4 µM -0.446881081027075 0.324440797369695 no 2287 0.327480462309197 733 981133 YIL048W NEO1
SGTC_2154 5570129 200 µM -0.447552943372317 0.324190545009429 no 2288 0.327237935222975 765 673366
SGTC_555 4296-0685 37 µM -0.447648875247989 0.32415481919819 no 2289 0.327203311935966 750 2908540 YHR072W ERG7
SGTC_532 1548-0774 215 µM -0.448355960485458 0.323891544867817 no 2290 0.326948159899798 779 5932993
SGTC_996 3970-0799 1.8 µM -0.448489578176244 0.323841803885363 no 2291 0.326899952976647 715 6615648 YGL040C HEM2
SGTC_1765 st044815 90.4 µM -0.448599246075637 0.323800980885415 no 2292 0.326860388877326 731 645695
SGTC_635 k038-0028 24.7 µM -0.449354272211339 0.32351998598624 no 2293 0.32658805637679 764 4035102
SGTC_2157 5649910 96.377 µM -0.449910711973036 0.323312962525853 no 2294 0.326387411675737 750 2858091
SGTC_832 4083-0019 164 µM -0.450840681178695 0.322967089524522 no 2295 0.326052189414757 752 1990758
SGTC_1508 1080-0625 72.9 µM -0.452420824162463 0.322379755735887 no 2296 0.32548292397157 743 767111
SGTC_1795 st049545 62.3 µM -0.452902677112972 0.32220074072133 no 2297 0.325309411563266 703 5291882
SGTC_2117 5521686 200 µM -0.452964802681361 0.322177663216233 no 2298 0.325287043266939 734 803312
SGTC_1006 4099-6547 255 µM -0.453015939523236 0.32215866815823 no 2299 0.325268631931304 746 3146833
SGTC_3322 9139058 2.11 µM -0.453227664680795 0.322080026640396 no 2300 0.325192406832544 729 4908926 YPR165W RHO1
SGTC_858 0438-0351 2.77 µM -0.455210862479246 0.321343790485043 no 2301 0.324478773252322 731 2799119
SGTC_2380 9035439 200 µM -0.455414390369288 0.321268273065769 no 2302 0.32440557220571 734 6462575
SGTC_2645 abamectin 100 µM -0.455781430311273 0.321132104468284 no 2303 0.324273579401139 744 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2078 5212016 200 µM -0.456804320789237 0.320752748010942 no 2304 0.323905849928661 758 1899708
SGTC_1097 itavastatin 7.23 µM -0.457564620233733 0.320470899130494 no 2305 0.323632633300765 727 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2752 diclazuril 33.15 µM -0.45774170188242 0.320405268449949 no 2306 0.323569011946296 729 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.459064848890955 0.319915056504627 no 2307 0.323093799051479 767 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_195 4234-0266 16.654 µM -0.459189941122495 0.319868727407868 no 2308 0.32304888665707 734 2303354
SGTC_880 0833-0487 87.2 µM -0.459428811552309 0.319780267279742 no 2309 0.32296313116053 731 76075
SGTC_715 0868-0130 184 µM -0.459539092277148 0.319739430826904 no 2310 0.322923543087997 737 2876258
SGTC_1967 st070177 51.4 µM -0.46136087198668 0.319065150548207 no 2311 0.322269859496419 777 5729214
SGTC_676 falcarinol 140 µM -0.461954252457672 0.318845656585052 no 2312 0.322057063615685 784 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.46238804003522 0.318685236901634 no 2313 0.32190153723965 730 23665772 A membrane-active detergent.
SGTC_1546 5-methoxyflavanone 78.7 µM -0.462648824599105 0.318588812091135 no 2314 0.321808052851079 731 147795
SGTC_3265 9137266 49.47 µM -0.468368830151975 0.316476945361764 no 2315 0.31976042712214 717 17224265
SGTC_1512 0259-0544 12.2 µM -0.468430186477045 0.316454324414621 no 2316 0.319738492623429 717 18476
SGTC_1150 3909-7983 10.9 µM -0.468793706864156 0.316320315230401 no 2317 0.319608549315147 743 23965914
SGTC_868 0527-0199 213 µM -0.469178771990691 0.316178390037074 no 2318 0.319470928815361 758 2849450
SGTC_865 0488-0499 301 µM -0.469281882928066 0.316140390568666 no 2319 0.319434081661242 756 9634651
SGTC_1143 3454-2408 5.08 µM -0.472063519144409 0.315116008255397 no 2320 0.318440725352026 750 X1143
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.472709661757185 0.314878258811316 no 2321 0.318210166270151 740 5379071
SGTC_1057 3448-5381 134 µM -0.474319882361105 0.314286108862723 no 2322 0.317635907718703 743 5497911
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.474863546027469 0.314086287256114 no 2323 0.317442118008144 758 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3017 9080681 49.47 µM -0.476726003573134 0.313402161107142 no 2324 0.316778621774778 764 16451914
SGTC_1562 morin hydrate 59.1 µM -0.477281279160772 0.313198318854608 no 2325 0.316580919988637 763 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3292 9120825 59.784 µM -0.478421170397751 0.312780042451805 no 2326 0.316175234314068 776 24824900
SGTC_2394 5221648 200 µM -0.478725097749746 0.31266855875706 no 2327 0.316067104332051 750 788586
SGTC_2325 6158266 200 µM -0.478897971824169 0.312605154404346 no 2328 0.316005606946727 728 3623240
SGTC_1250 0485-0349 40.2 µM -0.47974138968557 0.312295896868757 no 2329 0.315705646601084 753 6842794 YDL195W SEC31
SGTC_1473 k844-0725 134 µM -0.479938113117644 0.312223782940265 no 2330 0.315635699642782 738 54682906
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.480236507119181 0.312114412835237 no 2331 0.315529615315597 727 688664
SGTC_2161 5662504 8.5105 µM -0.480313831421242 0.312086073924156 no 2332 0.315502127642863 715 2859334
SGTC_72 0744-0168 198.391 µM -0.482467863872496 0.311297080904789 no 2333 0.314736810994701 777 677577
SGTC_1773 st048542 73.5835 µM -0.482763739817733 0.311188773112515 no 2334 0.314631749828012 767 3237138
SGTC_215 1287-0124 461.5 µM -0.484741341649387 0.310465276020619 no 2335 0.313929918378276 756 5560863
SGTC_872 0588-0139 234 µM -0.485235894842688 0.310284460280398 no 2336 0.313754511342088 718 2047100
SGTC_2764 methyldopa 94.69 µM -0.48544816413123 0.310206865644323 no 2337 0.313679237046223 775 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1799 st045822 46.1415 µM -0.485535624377562 0.310174897174669 no 2338 0.313648224413169 775 3674992
SGTC_2195 6536160 144.242 µM -0.486555661066768 0.309802159341401 no 2339 0.313286625679778 736 3834386
SGTC_2955 9076254 12.21 µM -0.491219931384099 0.308100254720599 no 2340 0.311635451689848 759 16459619
SGTC_3042 9091578 49.47 µM -0.493039287305193 0.307437520255418 no 2341 0.310992413951216 743 25236497
SGTC_1841 st054148 70 µM -0.493886189151954 0.307129234517444 no 2342 0.310693279389387 772 675442
SGTC_1811 st050069 61.5 µM -0.495211869380865 0.30664693950358 no 2343 0.310225286535045 771 3877702
SGTC_1278 0874-0585 172 µM -0.496669136580121 0.306117157965868 no 2344 0.309711195126015 741 766306
SGTC_1906 st060206 94.7 µM -0.497357225773513 0.305867147668354 no 2345 0.30946858181288 778 5133468
SGTC_1300 1094-0077 113 µM -0.497470512129636 0.305825994876034 no 2346 0.309428646142217 740 5532636
SGTC_744 1594-0068 283 µM -0.499643344994186 0.30503715907072 no 2347 0.308663115781077 758 668392
SGTC_1192 1488-0095 21.4 µM -0.500788179018764 0.304621896750027 no 2348 0.308260102921785 785 915875
SGTC_2580 diallyl disulphide 81.36 µM -0.501841993150241 0.3042398722153 no 2349 0.307889335714482 737 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1503 4585-0012 61.3 µM -0.50439035846103 0.303316932128537 no 2350 0.306993545993062 771 2922052
SGTC_456 gingerol 170 µM -0.506351286307494 0.302607597079661 no 2351 0.306305032755467 792 442793 A herb.
SGTC_285 1486-1325 46 µM -0.506732421804342 0.302469813592297 no 2352 0.306171289215672 753 22310230
SGTC_1557 sumaresinolic acid 42.3 µM -0.508352496111502 0.301884458121746 no 2353 0.305603080386823 756 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_219 mitoxanthrone 164.414 µM -0.508792357282671 0.301725618043955 no 2354 0.305448888528346 773 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1348 1493-0373 93.8 µM -0.509542597150421 0.301454782578816 no 2355 0.305185974085058 788 3010129
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.510124205934136 0.301244897999876 no 2356 0.30498222394562 749 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2004 4023728 41.89 µM -0.510583163808288 0.301079320808221 no 2357 0.304821483737607 768 360084 YDR527W RBA50
SGTC_1376 2910-0861 41.3 µM -0.510813551800083 0.300996219719923 no 2358 0.304740809453239 779 1112859
SGTC_893 0958-0369 48.9 µM -0.511430012940573 0.300773912680544 no 2359 0.304524991767224 784 6819948
SGTC_2292 7671323 168.05 µM -0.511643022436482 0.300697114827567 no 2360 0.304450434806451 765 937504
SGTC_3030 9087619 49.47 µM -0.512456790861314 0.300403802537774 no 2361 0.304165676797514 750 25236973
SGTC_3177 9107506 49.47 µM -0.513842417942214 0.29990466887951 no 2362 0.303681084345886 770 8897194
SGTC_274 sirtinol 40.1 µM -0.514352504569834 0.299721018918962 no 2363 0.303502779638082 736 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2651 TUB2.036 5 µM -0.515298087928069 0.299380708912666 no 2364 0.303172367445345 762 15992207 YFL037W TUB2
SGTC_449 xestospongin c 11.1929 µM -0.51588640991979 0.299169063682645 no 2365 0.30296687317015 773 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_358 0075-0058 9.45 µM -0.516109834450659 0.29908870587168 no 2366 0.302888849821641 828 1069125
SGTC_125 0133-0007 11.75 µM -0.516386642143743 0.298989161639688 no 2367 0.302792196713972 772 26541
SGTC_3029 9088683 49.47 µM -0.516444074139095 0.298968510110614 no 2368 0.302772144880111 751 25236615
SGTC_1855 st056195 39.6 µM -0.517316071886588 0.298655034778615 no 2369 0.302467768271315 746 4028379
SGTC_1311 1190-0148 100 µM -0.517827936943696 0.298471093543824 no 2370 0.302289162300537 768 1961333
SGTC_390 dec-rvkr-cmk 16.7 µM -0.518736859988665 0.29814459465909 no 2371 0.30197212686523 752 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2136 5328288 199.296 µM -0.519025949076399 0.298040783606092 no 2372 0.30187132292838 754 262395
SGTC_257 daunorubicin 18.5 µM -0.519316233238702 0.297936559982642 no 2373 0.301770117492816 766 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_103 0844-0104 51.839 µM -0.519905471593415 0.297725050958569 no 2374 0.301564730798507 771 5375804
SGTC_3327 9140648 26.9345 µM -0.521885104697505 0.297014957417912 no 2375 0.300875164944303 770 8029710
SGTC_348 k064-0012 10.7 µM -0.522384336187934 0.296836005681885 no 2376 0.300701379923459 763 5066323
SGTC_1948 st076329 66.6 µM -0.523069479334893 0.296590493457372 no 2377 0.300462951886582 781 24208413
SGTC_2108 5365811 200 µM -0.523758780327839 0.296343585234131 no 2378 0.300223163141432 743 780283
SGTC_2171 5739187 198.077 µM -0.525412217802084 0.295751706978552 no 2379 0.299648330966311 743 2262761
SGTC_343 4130-2827 29.8 µM -0.525484850681117 0.295725719166419 no 2380 0.299623090939899 751 1118244
SGTC_1505 k297-0037 20.6 µM -0.526171180223137 0.295480204469378 no 2381 0.299384638042412 753 4089396
SGTC_3038 9091290 49.47 µM -0.526692914035976 0.295293631910996 no 2382 0.299203428577075 787 25236843
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.527726915755193 0.294924032103073 no 2383 0.298844444510322 776 688669
SGTC_321 4534-3890 65.3 µM -0.528078188197813 0.294798519693345 no 2384 0.298722534515746 768 699746
SGTC_3335 9143315 29.6265 µM -0.528635235964455 0.294599532646051 no 2385 0.29852925603717 747 4899691
SGTC_1406 3909-7906 11.9 µM -0.529109145111875 0.294430292944059 no 2386 0.298364868907265 762 X1406
SGTC_1336 1486-0901 104 µM -0.529983855071273 0.294118039493838 no 2387 0.298061562344475 762 5006114
SGTC_665 3914-0008 307 µM -0.53009117392813 0.294079739413536 no 2388 0.298024359100659 773 1069549
SGTC_2593 nobiletin 86.24 µM -0.530878449172935 0.293798846203688 no 2389 0.297751506341175 758 72344 An anti-infammatory.
SGTC_2915 7971052 15.16 µM -0.530925542679954 0.293782047570476 no 2390 0.297735188351857 769 5741558
SGTC_2048 5246248 200 µM -0.531143630966523 0.293704259517355 no 2391 0.297659625667797 760 677046
SGTC_2018 5133068 143 µM -0.531150112345278 0.293701947875445 no 2392 0.297657380149806 799 785362
SGTC_3236 9132701 49.47 µM -0.531218820612965 0.293677442972836 no 2393 0.297633576175968 776 24282524
SGTC_709 3807-1509 243 µM -0.53212227658787 0.29335531216828 no 2394 0.297320654776891 803 1886677 YPL242C IQG1
SGTC_735 3076-0345 636 µM -0.532658927588352 0.29316404467577 no 2395 0.297134851296368 766 2888990
SGTC_335 4077-0256 27.6 µM -0.53466608120264 0.292449189249065 no 2396 0.296440390023823 788 3121989
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.534816920701911 0.292395499936553 no 2397 0.29638823066722 790 5355888
SGTC_2849 9019321 12.99 µM -0.536055676275879 0.291954754831513 no 2398 0.295960035970244 742 16489627
SGTC_1937 st074714 47.2 µM -0.536380889201761 0.291839096447527 no 2399 0.295847668266307 766 17250970
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.536727907182055 0.291715706881075 no 2400 0.295727788085926 764 2333 A French combination drug.
SGTC_3009 9080819 71.4286 µM -0.538294694322884 0.29115890558236 no 2401 0.295186806852634 781 17027216
SGTC_1212 0520-0165 585 µM -0.538517560120095 0.291079744368487 no 2402 0.295109892640665 826 5403258
SGTC_1195 1502-0147 41.1 µM -0.538554098356945 0.291066767063584 no 2403 0.295097283646975 766 817940
SGTC_2481 5478948 45.16 µM -0.539149207731221 0.290855439809101 no 2404 0.294891952071199 761 77792
SGTC_632 0781-2353 4.65 µM -0.539707965781616 0.290657086456662 no 2405 0.294699222810232 781 6811515 YHR007C ERG11
SGTC_856 0433-0016 11.3 µM -0.540006676580721 0.290551073161313 no 2406 0.294596214014628 777 3911780
SGTC_2803 7707263 71.43 µM -0.540399883991526 0.290411550346401 no 2407 0.294460643907034 765 2199229
SGTC_2861 9024595 19.48 µM -0.542057803115789 0.289823611783437 no 2408 0.293889343252924 746 16482810
SGTC_1146 3579-1023 7 µM -0.543318680793524 0.289376847947355 no 2409 0.293455202202112 801 X1146
SGTC_1788 fluconazole 20 µM -0.545190164108143 0.288714326842248 no 2410 0.292811367810146 798 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_142 0335-0849 62.6745 µM -0.546215013356111 0.288351824370375 no 2411 0.292459073623525 767 3889043 YPR107C YTH1
SGTC_1444 4112-3581 28 µM -0.546293309506891 0.288324138832202 no 2412 0.292432167252381 768 2877249
SGTC_2611 pyromycin 23.93 µM -0.546380503807745 0.288293308381228 no 2413 0.292402204397904 770 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1113 artemisinin 1.17947 µM -0.546599197744565 0.288215988691823 no 2414 0.292327060186165 785 2240 An anti-malaria and mitochondrial poison.
SGTC_1439 4092-1168 46 µM -0.546762797143204 0.288158154185763 no 2415 0.292270852576114 786 2886240
SGTC_2653 dihydrofissinolide 100 µM -0.54716145088798 0.288017247856025 no 2416 0.292133908736474 760 6857746
SGTC_2514 salinomycin 42.74 µM -0.549275965110009 0.287270405621436 no 2417 0.291408039529124 779 23682228 A polyether potassium ionophore.
SGTC_2212 7123476 200 µM -0.549423962907541 0.287218167427422 no 2418 0.291357266455524 767 1085715
SGTC_1157 4092-0394 27.6 µM -0.549682969565931 0.287126757698126 no 2419 0.291268419905187 785 3659885
SGTC_1258 0671-0043 57.1 µM -0.550203968108888 0.286942926411481 no 2420 0.291089741102681 800 4298767
SGTC_911 3456-4043 236 µM -0.550768227533712 0.286743893694329 no 2421 0.290896283553478 780 914281
SGTC_1171 0368-0077 21.4 µM -0.55175728665039 0.286395178248938 no 2422 0.290557327579467 775 3239779
SGTC_690 glyoxal 20.3 µM -0.552829498198329 0.286017373038084 no 2423 0.290190083718201 787 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_173 1273-0061 2.693 µM -0.552842469469444 0.286012803922303 no 2424 0.290185642251535 780 2847414 YPL266W DIM1
SGTC_2338 7999974 200 µM -0.554128573758131 0.285559947441095 no 2425 0.289745428105265 801 315925
SGTC_2143 5623677 140.463 µM -0.554973448449792 0.285262640333145 no 2426 0.289456410860526 761 5375313
SGTC_1398 3558-0053 112 µM -0.555099735037787 0.285218213397555 no 2427 0.289413222004945 761 4532369
SGTC_2343 7990716 14.84 µM -0.55512431961624 0.285209565059825 no 2428 0.289404814656489 799 6456862
SGTC_1902 st060212 70.5 µM -0.555510114467144 0.28507386691326 no 2429 0.289272896908038 756 688944
SGTC_888 0916-0002 6.97 µM -0.55746707974143 0.284386005204053 no 2430 0.28860417265311 764 2802138 YIL048W NEO1
SGTC_1335 1486-0900 202 µM -0.557686568105868 0.284308905834947 no 2431 0.288529215644561 768 X1335
SGTC_1999 st074831 12.5 µM -0.558555787263672 0.284003674608002 no 2432 0.288232460577211 808 17112523
SGTC_297 0986-0032 24 µM -0.558653215802638 0.283969471799223 no 2433 0.288199207039873 792 2847425
SGTC_931 2812-0076 566 µM -0.558735668549407 0.283940527862177 no 2434 0.288171066335299 794 3450959
SGTC_2095 5432005 200 µM -0.559081310348722 0.283819210284742 no 2435 0.288053114650437 814 783734
SGTC_2776 terbinafine 19.92 µM -0.560614282890323 0.283281448180611 no 2436 0.287530256298888 761 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2545 solidagenone 89.61 µM -0.561084018814598 0.283116764113655 no 2437 0.287370131060489 739 6708572 An anti ulcer agent
SGTC_2742 clothiapine 36.27 µM -0.562717656865166 0.282544387203759 no 2438 0.286813579479559 776 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_544 k015-0020 52.4 µM -0.56281713178076 0.28250955220693 no 2439 0.286779706643253 792 3008304
SGTC_1552 6-methylflavone 10.6 µM -0.563558500712193 0.282249998211853 no 2440 0.2865273181406 801 689013
SGTC_3065 9113888 49.47 µM -0.563704190892596 0.282199005430768 no 2441 0.286477732383654 799 16648368
SGTC_1031 k035-0009 16 µM -0.56441146967834 0.281951514979196 no 2442 0.28623706742699 802 5180959
SGTC_2163 5671233 125 µM -0.565520813653926 0.281563544919234 no 2443 0.285859785710163 767 701023
SGTC_994 3910-0338 138 µM -0.567858601654273 0.280746796112266 no 2444 0.285065492113416 795 3479481
SGTC_237 nikkomycin 200 µM -0.56786629330741 0.280744110785395 no 2445 0.285062880512738 798 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_595 3909-8003 73.7 µM -0.569487460230004 0.280178402823168 no 2446 0.284512689128454 799 699517
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.569546724035619 0.280157733122469 no 2447 0.284492585800592 777 66535 A nucleotide analog.
SGTC_2468 5987765 72.9 µM -0.571629519778299 0.279431776883067 no 2448 0.283786496074846 760 26772094
SGTC_2027 5150920 200 µM -0.571807728715123 0.27936970480489 no 2449 0.283726120354835 772 786715
SGTC_2646 retinol 96.75 µM -0.572188453420123 0.279237116765185 no 2450 0.283597154573328 796 445354 A vitamin A analog and teratogen.
SGTC_11 0438-0307 1.3 µM -0.574360490940932 0.278481286394763 no 2451 0.28286194140634 789 4011476
SGTC_1685 st024049 53.0905 µM -0.574854963983597 0.2783093579704 no 2452 0.282694695190164 790 1941139
SGTC_2383 9036125 200 µM -0.576893795751832 0.277601002562881 no 2453 0.282005601004662 784 79580
SGTC_1252 0493-0875 34.8 µM -0.57804532031816 0.277201315701184 no 2454 0.281616761008543 770 3960963
SGTC_294 k038-0071 157 µM -0.578163012292522 0.277160481426847 no 2455 0.281577034047465 784 24152826
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.579049640378407 0.276852952584042 no 2456 0.281277839385603 768 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1277 0873-0036 22 µM -0.580128140400385 0.276479097971274 no 2457 0.28091410413122 790 5965735
SGTC_2952 9073731 13.78 µM -0.581217040851875 0.276101889431542 no 2458 0.280547092033517 802 16457353
SGTC_2925 9010536 32.5 µM -0.582429239249836 0.275682266365502 no 2459 0.280138795711164 777 2994177
SGTC_2964 9083345 53.42 µM -0.58310530229083 0.275448371920447 no 2460 0.279911207265297 782 17741579
SGTC_751 0833-0568 350 µM -0.583920233669766 0.275166563654434 no 2461 0.27963698971092 801 6954252
SGTC_123 0083-0120 66.675 µM -0.584850470820828 0.274845055558206 no 2462 0.279324132191345 795 16001701
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.585448057543642 0.274638615659856 no 2463 0.279123241478624 776 2724 A muscle relaxant with antifungal properties.
SGTC_703 3875-0075 71.8 µM -0.58550628689353 0.274618504073412 no 2464 0.279103670276071 819 2850814
SGTC_63 0099-0242 26.702 µM -0.586155783789863 0.274394226367836 no 2465 0.278885416060074 794 3898502 YLR359W ADE13
SGTC_1436 4092-1007 8.32 µM -0.58825618409606 0.273669556884792 no 2466 0.278180175376202 764 2881121
SGTC_2610 ononetin 44.17 µM -0.589777366965134 0.273145317908793 no 2467 0.277669959186417 790 259632
SGTC_1611 st001856 99.4 µM -0.590146037741966 0.273018339379015 no 2468 0.277546373083832 818 647478
SGTC_2619 obliquin 87.91 µM -0.593088603876454 0.272005903353673 no 2469 0.276560928375677 797 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2339 9000433 200 µM -0.593125874526168 0.271993091786214 no 2470 0.276548457705341 772 2988954
SGTC_1442 4112-3290 3 µM -0.593202802313057 0.271966649259215 no 2471 0.276522718723403 810 704353
SGTC_2386 9075165 157.42 µM -0.593255509478348 0.271948532868327 no 2472 0.276505084307157 796 16452277
SGTC_949 1165-0505 146 µM -0.593256713626847 0.271948118988067 no 2473 0.276504681437525 778 6244267
SGTC_930 2810-3379 265 µM -0.594037046460883 0.271679975154855 no 2474 0.276243667532923 824 1015764
SGTC_3002 9075603 71.4286 µM -0.594408612959506 0.271552340955319 no 2475 0.276119424582557 803 20105405
SGTC_2240 6690706 185.951 µM -0.5949881674035 0.271353321908673 no 2476 0.275925690215577 782 805876
SGTC_2770 toltrazuril 17.5 µM -0.595072718174353 0.271324293243232 no 2477 0.275897432033545 783 68591 Kills coccidiodes.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.596047064059568 0.270989884527115 no 2478 0.275571893118814 792 16486 A toxic proline analog.
SGTC_396 dithiazanine 1.25 µM -0.596150937462989 0.270954245899573 no 2479 0.275537199098737 783 10578 An antihelmenthic.
SGTC_505 gw-5074 63.9 µM -0.596612039365655 0.270796071569795 no 2480 0.275383215655253 796 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_310 1273-0058 1.06 µM -0.596977449010775 0.270670755828754 no 2481 0.275261218403297 777 2734232
SGTC_712 r015-0009 80.6 µM -0.598692183361085 0.270083081791713 no 2482 0.274689085333305 784 6813872 YLR060W FRS1
SGTC_2674 ligustilide 100 µM -0.59965379570921 0.269753797442356 no 2483 0.274368493517748 772 5319022 A signalling regulator.
SGTC_961 1252-1571 372 µM -0.599762156415592 0.269716704157749 no 2484 0.274332378738672 815 6813498
SGTC_1627 st003713 25.6 µM -0.601320437646965 0.269183566827285 no 2485 0.273813289819969 781 16195070 YER133W GLC7
SGTC_637 1181-0519 7.26 µM -0.603323722955126 0.268498957103406 no 2486 0.273146677143714 798 6252091 YGR060W ERG25
SGTC_1071 trifluoperazine 6.31 µM -0.6037408209111 0.268356526766102 no 2487 0.273007984961477 825 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1414 3917-0015 5.4 µM -0.603991756400456 0.268270855790915 no 2488 0.272924561456041 806 6618702
SGTC_2118 5526350 200 µM -0.605123382741125 0.267884682358034 no 2489 0.272548509384478 802 743594
SGTC_2873 9040596 71.43 µM -0.605271384789612 0.267834196593367 no 2490 0.272499345679658 840 6463863
SGTC_1616 st002734 56.1 µM -0.605998570492613 0.26758621206537 no 2491 0.272257851234333 794 4026101
SGTC_212 3807-4682 38.772 µM -0.607802919747997 0.266971394071418 no 2492 0.271659096290075 797 3125501 YBL034C STU1
SGTC_2921 7974240 10.71 µM -0.608423461980688 0.26676011412999 no 2493 0.271453327266506 799 2979074 YDR527W RBA50
SGTC_1527 coumarin 137 µM -0.608466782709011 0.266745367603686 no 2494 0.271438965207073 840 323 A hepatotoxic, DNA x-linker.
SGTC_3069 9117009 49.47 µM -0.60968493341368 0.266330873628628 no 2495 0.271035268488543 785 41904981
SGTC_2716 st080858 38.6235 µM -0.609851857643486 0.266274100568312 no 2496 0.27097997292314 788 5296050
SGTC_324 1315-0088 19.6 µM -0.612105637771104 0.265508161356923 no 2497 0.270233933860754 810 6787421
SGTC_1683 st010134 710 nM -0.613133764998869 0.265159127567935 no 2498 0.269893947945579 823 3818134
SGTC_428 3448-4153 16.5 µM -0.615179137516606 0.264465447830377 no 2499 0.269218211925409 773 3834874
SGTC_1523 st012844 44.7 µM -0.615372087662055 0.264400057278127 no 2500 0.269154510224257 801 4274103
SGTC_639 0833-0042 114 µM -0.615450463162947 0.26437349827381 no 2501 0.269128637033219 818 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2000 st075254 36.4 µM -0.615899625045002 0.264221317566958 no 2502 0.268980384526943 778 17234175
SGTC_1768 st044301 37.178 µM -0.616257468097274 0.264100108564648 no 2503 0.268862302495518 841 3931349
SGTC_1692 fluoroquinolonic acid 71 µM -0.617010373315495 0.263845176195567 no 2504 0.268613941800795 811 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_458 nppb 133 µM -0.617337498630088 0.263734451257221 no 2505 0.268506068979465 799 4549 A chloride channel blocker.
SGTC_296 1222-0039 74.9 µM -0.617382606813684 0.263719184959128 no 2506 0.268491195816675 796 5984176
SGTC_71 0417-1750 47.813 µM -0.617423950116141 0.263705193233636 no 2507 0.268477564381998 769 6811472
SGTC_7 0192-1582 4.227 µM -0.617645134408772 0.263630344738275 no 2508 0.268404642900423 830 252616
SGTC_2025 5147754 141 µM -0.618242601080826 0.263428216938549 no 2509 0.268207715989566 785 315777 YLR208W SEC13
SGTC_2319 6033012 152.6 µM -0.61867421787728 0.263282246725707 no 2510 0.268065498968366 808 847246
SGTC_537 1334-0398 209 µM -0.619604066743043 0.262967917831105 no 2511 0.267759244341825 800 5846986
SGTC_1792 st045773 43.6 µM -0.61977229541921 0.262911069805555 no 2512 0.267703855455449 761 2919270
SGTC_896 0964-0007 44.5 µM -0.621359115546076 0.262375159067538 no 2513 0.267181683015863 788 6756758
SGTC_3197 9113331 49.47 µM -0.621785768437034 0.262231162688742 no 2514 0.26704137275877 788 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_511 blebbistatin 171 µM -0.62426231701733 0.261396121882411 no 2515 0.266227663602823 804 3476986 A myosin inhibitor.
SGTC_2779 methotrexate 400 µM -0.62483760217047 0.261202343304714 no 2516 0.266038824382151 806 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2602 kawain 100 µM -0.625221227376531 0.26107316434335 no 2517 0.26591293587788 804 5369129
SGTC_2601 securinine 100 µM -0.626518363986233 0.260636620061068 no 2518 0.265487497791376 833 442872 A GABA receptor antagonist.
SGTC_2148 5546263 113.568 µM -0.627350487219593 0.26035677146208 no 2519 0.265214757887184 795 792097
SGTC_1135 dihydrocapsaicin 536.708 nM -0.629166823728235 0.259746463495111 no 2520 0.264619923064177 814 107982 A Capsaicinoid.
SGTC_2211 7117706 200 µM -0.630056753882697 0.259447707418304 no 2521 0.264328726380994 797 822771
SGTC_384 k007-0144 5.16 µM -0.630285994367245 0.259370778465628 no 2522 0.264253742356171 819 6824886
SGTC_1379 2144-0755 36.5 µM -0.630293828016381 0.259368149843175 no 2523 0.264251180179325 823 5392327
SGTC_1405 3909-7894 12 µM -0.632091925154975 0.258765153178403 no 2524 0.263663405661356 812 7104060
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.634127598130612 0.258083361541547 no 2525 0.262998776573809 848 6728940
SGTC_1807 st050092 58.9 µM -0.635362838966243 0.257670106824172 no 2526 0.262595899325308 817 5008496
SGTC_2458 5808907 16.39 µM -0.635501178701519 0.257623846119815 no 2527 0.262550799108355 824 2731747
SGTC_2348 9022543 33.42 µM -0.637681273285164 0.256895394021934 no 2528 0.261840589111627 818 3162678 YDL140C RPO21
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.638003806957599 0.256787714403339 no 2529 0.261735600965194 829 165506
SGTC_944 3370-0224 231 µM -0.639077638590914 0.256429379269778 no 2530 0.261386213050697 791 4580514
SGTC_1445 4239-0156 97.7 µM -0.639085441176551 0.256426776518788 no 2531 0.261383675234287 818 4008346
SGTC_894 0960-0238 55.9 µM -0.639746726204481 0.256206238101045 no 2532 0.261168636118376 826 6741907 YDL195W SEC31
SGTC_1790 st045711 43.5 µM -0.641061370218483 0.255768098502687 no 2533 0.260741405503972 772 585119
SGTC_34 0469-0683 81.75 µM -0.641551033487623 0.255605005411012 no 2534 0.260582367596165 795 3690923
SGTC_919 tnp00227 403.569 nM -0.642556133935332 0.255270404914551 no 2535 0.260256077189328 829 1269246 A methoxyflavone. YNL221C POP1
SGTC_2255 7941087 197.44 µM -0.643040913832227 0.255109102349698 no 2536 0.260098776143763 804 935561
SGTC_1007 4101-0031 70 µM -0.645399872147517 0.254324959143115 no 2537 0.2593340431214 826 1146276
SGTC_2176 5809774 33.9695 µM -0.645899374418995 0.254159081438512 no 2538 0.259172262393275 794 2870539
SGTC_2075 5212009 200 µM -0.649259089641106 0.253044843101495 no 2539 0.258085461981031 827 780898
SGTC_2433 5607874 27.82 µM -0.65044265719593 0.252652929911833 no 2540 0.257703165337074 817 2252428
SGTC_1021 4476-0760 85.3 µM -0.652533493913156 0.251961375868478 no 2541 0.257028536537079 803 746768
SGTC_2838 9002687 71.43 µM -0.653635033398526 0.251597438699075 no 2542 0.256673483945927 817 6457060
SGTC_1864 st057645 30.4 µM -0.653841713954216 0.251529184550066 no 2543 0.256606894311431 827 688666
SGTC_740 k014-0057 261 µM -0.653936123073285 0.251498010155243 no 2544 0.256576479984547 822 4012779
SGTC_1997 st073024 93.8 µM -0.656175766611604 0.25075906701331 no 2545 0.255855519593568 815 686268
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.656216358648074 0.250745684779766 no 2546 0.2558424624324 845 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2059 5238311 157 µM -0.656484033939219 0.250657448042639 no 2547 0.255756368553092 820 703021
SGTC_1645 Cervolide 78 µM -0.656643093020219 0.250605023447091 no 2548 0.255705216669245 822 23173 A fragrance.
SGTC_41 0478-0632 82.643 µM -0.658073175753619 0.250133940654528 no 2549 0.255245555726329 841 3750424
SGTC_774 k060-0086 136 µM -0.658413490041351 0.25002190713466 no 2550 0.255136234684869 823 5911235
SGTC_506 n9-isopropylolomoucine 153 µM -0.658548548476626 0.2499774524628 no 2551 0.255092855904989 813 6610355
SGTC_168 3970-0862 530.542 µM -0.660520317929284 0.249328919716056 no 2552 0.254459992151966 829 3135186
SGTC_3284 9108171 64.8615 µM -0.661992097158089 0.248845421897553 no 2553 0.253988143237626 809 8687505
SGTC_3027 9089541 49.47 µM -0.662581293089038 0.248652003685622 no 2554 0.253799377190215 822 9943819
SGTC_2049 5262831 67.185 µM -0.662658851744231 0.248626549094179 no 2555 0.253774534506836 819 763417
SGTC_1871 st057448 67.3 µM -0.663189249196324 0.248452510948157 no 2556 0.253604678009544 843 691747
SGTC_630 4356-0227 183 µM -0.664246157251978 0.248105903713054 no 2557 0.253266387899217 840 779312
SGTC_156 3474-0145 5.642 µM -0.665182932599173 0.247798909101455 no 2558 0.252966747756842 810 2265471
SGTC_2627 acetyl isogambogic acid 100 µM -0.665415762006259 0.247722639069991 no 2559 0.25289230310792 829 6857789 A caspase activator and apoptosis inducer.
SGTC_1663 st014140 55.4 µM -0.665938068453169 0.24755158804313 no 2560 0.2527253433085 814 4207120
SGTC_56 0957-0365 83.25 µM -0.666651795355692 0.247317950469025 no 2561 0.252497288181102 805 6752360
SGTC_1369 1866-0067 208 µM -0.667452646265525 0.247055933371745 no 2562 0.252241523727191 818 3531355
SGTC_2998 9066762 71.4286 µM -0.671805688380646 0.245634334989904 no 2563 0.250853703467346 830 4945196
SGTC_1972 st070201 17.4 µM -0.672683647318572 0.245348148132392 no 2564 0.25057428659654 818 2829099
SGTC_807 1315-0151 48 µM -0.674160083001838 0.244867281158559 no 2565 0.250104772157203 843 4011080
SGTC_3071 9117417 49.47 µM -0.674431194373943 0.244779036830814 no 2566 0.250018608035922 828 45595590 YGL055W OLE1
SGTC_2879 9041815 71.43 µM -0.674655413313972 0.244706068506123 no 2567 0.24994735908347 807 4942971
SGTC_2868 9035608 32.47 µM -0.675417435324993 0.244458168678741 no 2568 0.249705295651431 821 6462614
SGTC_3202 9113761 49.47 µM -0.676475296408107 0.244114251362608 no 2569 0.249369462655964 828 4798415
SGTC_3255 9139072 49.47 µM -0.679136433122823 0.24325025404313 no 2570 0.24852570985741 831 17646060
SGTC_2439 5492030 7.2 µM -0.679909474271646 0.242999579201062 no 2571 0.248280891139225 825 5722370
SGTC_3047 9092122 49.47 µM -0.680612682209801 0.242771670669326 no 2572 0.248058300024232 831 17173831
SGTC_2743 auranofin 4.32 µM -0.682837409110408 0.242051402972632 no 2573 0.247354794110105 788 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2037 5169046 200 µM -0.6830452356261 0.241984177218176 no 2574 0.247289129461122 815 5718022
SGTC_2556 citropten 84.59 µM -0.683789328400992 0.241743568188813 no 2575 0.247054103122215 793 2775 A potential DNA crosslinker.
SGTC_2981 9013952 38.96 µM -0.685744059367015 0.241112107582729 no 2576 0.246437258897841 804 2996344
SGTC_2894 9048625 32.47 µM -0.687180608216746 0.240648613954187 no 2577 0.245984461383479 844 4092861
SGTC_446 go6976 132 µM -0.688581723774639 0.240197020262537 no 2578 0.245543262745714 840 3501 A protein kinase C inhibitor.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.695051031485118 0.238117898977601 no 2579 0.243511660611887 819 3256 An antibiotic and ribosome inhibitor.
SGTC_259 usnic acid 108.925 µM -0.695404171890957 0.238004690454473 no 2580 0.243401023400447 862 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2259 7964009 200 µM -0.697167350298122 0.237439898495151 no 2581 0.242849034553093 820 313134
SGTC_667 1498-1044 59 µM -0.697169205942171 0.237439304471885 no 2582 0.242848453973575 855 6739982
SGTC_1401 3807-4679 7.6 µM -0.697782697727854 0.237242960030699 no 2583 0.242656550600169 845 3291456
SGTC_1608 st001473 40.5 µM -0.697924852312161 0.237197477020843 no 2584 0.242612095637222 848 7292267
SGTC_1548 st061468 90.8 µM -0.700140173435522 0.236489294217767 no 2585 0.241919884663923 832 390799
SGTC_357 1325-0123 420 µM -0.700232842468058 0.236459695621741 no 2586 0.241890952172066 851 1098503
SGTC_1011 4112-3381 17.4 µM -0.701054173121391 0.236197450801642 no 2587 0.241634604001183 845 2877139
SGTC_426 0988-0037 14.6 µM -0.701860565461719 0.235940131596029 no 2588 0.241383061835762 837 5383008
SGTC_964 1287-0107 19.4 µM -0.702009614693747 0.235892587018731 no 2589 0.241336583714162 829 51516812 YPR165W RHO1
SGTC_1422 4031-0024 15.5 µM -0.702098937598238 0.235864096818243 no 2590 0.24130873242353 857 782427
SGTC_2938 9059746 27.26 µM -0.702435603743018 0.235756731713153 no 2591 0.241203774076586 843 6471769
SGTC_876 0720-0963 56.8 µM -0.702451279142475 0.235751733379173 no 2592 0.241198887750827 852 765861
SGTC_1210 3013-0140 750 nM -0.702456805323471 0.235749971288201 no 2593 0.241197165145955 826 905973
SGTC_2046 4110841 106 µM -0.702549226762903 0.235720502648693 no 2594 0.241168356798047 833 44119630 YMR134W ERG29
SGTC_1824 st053723 68.6 µM -0.703815723594575 0.235316883976515 no 2595 0.240773770210069 834 675225
SGTC_2449 5812982 45.77 µM -0.705120443885843 0.234901483180152 no 2596 0.240367642465806 841 776185
SGTC_37 0566-0070 1.56 µM -0.705164247837795 0.234887543780036 no 2597 0.240354013836948 839 1626686
SGTC_1329 1447-1697 50.6 µM -0.706878827392729 0.234342285397947 no 2598 0.239820891260849 834 2840515
SGTC_622 1348-1566 26.3 µM -0.707713420923593 0.234077127598443 no 2599 0.239561620644857 836 7340407
SGTC_2802 7925815 54.55 µM -0.708899153594112 0.233700695662615 no 2600 0.23919353019737 838 1262923
SGTC_1664 st014217 9.02 µM -0.709499961872309 0.233510086559151 no 2601 0.239007137573128 844 3982782
SGTC_2829 7992743 58.44 µM -0.709881117370444 0.233389207995141 no 2602 0.238888930427573 827 16462845
SGTC_2170 morpholine 200 µM -0.711365259086189 0.232918862463358 no 2603 0.238428960699633 831 121171 Reacts with secondary amines.
SGTC_1758 st042942 75.2445 µM -0.711441555264329 0.232894697361621 no 2604 0.238405327868147 843 669317
SGTC_3105 9121040 49.47 µM -0.71261898478605 0.232521949633832 no 2605 0.238040780369212 800 41448907
SGTC_3231 9132313 49.47 µM -0.712916467377098 0.232427825851558 no 2606 0.23794872426173 847 4905967
SGTC_1878 temozolomide 1 mM -0.713468252729043 0.232253296547109 no 2607 0.237778025751077 831 5394 DNA alkylating agent.
SGTC_330 1488-0319 80.1 µM -0.715422185917043 0.231635855595471 no 2608 0.23717410375574 839 6846614
SGTC_2003 4023581 200 µM -0.715463773841353 0.231622723802812 no 2609 0.237161258918208 852 16641307
SGTC_1191 1487-1166 10.6 µM -0.716743974806824 0.231218690893127 no 2610 0.236766043332357 864 3955771
SGTC_2096 5468907 200 µM -0.718924325508386 0.23053147566429 no 2611 0.236093773731151 837 759785
SGTC_1630 st005209 31.3 µM -0.719024191332302 0.230500026754403 no 2612 0.236063007213831 829 3367314
SGTC_2555 cholic acid 100 µM -0.71999254999168 0.230195203734631 no 2613 0.235764791279854 841 6708657 Influences liver metabolism.
SGTC_586 0957-0265 8.15 µM -0.720387008645876 0.230071099447668 no 2614 0.235643373280346 840 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1305 1181-0477 144 µM -0.721582039400644 0.229695348372626 no 2615 0.235275742435191 854 6252086
SGTC_2474 5321570 43.32 µM -0.721688549706569 0.229661875245209 no 2616 0.235242991730894 845 2841384
SGTC_842 0271-0008 11.1 µM -0.721749487108438 0.229642725600351 no 2617 0.23522425530694 824 1221709
SGTC_2015 5119600 184 µM -0.721796150167218 0.229628062288048 no 2618 0.235209908372593 846 2828786
SGTC_2287 7945887 168.79 µM -0.722164312653667 0.229512389992166 no 2619 0.235096730789517 840 1245853
SGTC_1617 st002906 78 µM -0.723938256417811 0.228955495766391 no 2620 0.234551820983987 852 5150859
SGTC_535 2293-4129 48.2 µM -0.727959165787576 0.227696022964764 no 2621 0.233319291595808 882 396118 YIL048W NEO1
SGTC_3270 9137563 49.47 µM -0.728662188578178 0.22747621579889 no 2622 0.233104163736413 820 17015724
SGTC_2384 9036245 200 µM -0.729637904988823 0.22717134635553 no 2623 0.232805773086376 818 6462766
SGTC_2121 5257820 149.641 µM -0.730019784481422 0.227052088164561 no 2624 0.232689045664747 819 791256
SGTC_1266 0828-0227 32.9 µM -0.731025791605711 0.226738088491327 no 2625 0.232381699677395 866 3913820
SGTC_192 3455-0609 60.9 µM -0.732102710736098 0.226402227144674 no 2626 0.232052939709368 831 3769639
SGTC_581 0958-0271 211 µM -0.732263556100407 0.226352088042759 no 2627 0.232003859355533 838 4591145
SGTC_1426 4048-4480 71.7 µM -0.733120063088077 0.226085201277067 no 2628 0.231742602175875 848 14224343
SGTC_1248 0469-0687 58.6 µM -0.733170213621032 0.226069579932279 no 2629 0.231727310024551 839 4017482
SGTC_146 3448-8650 53.125 µM -0.733741892170894 0.225891551410687 no 2630 0.231553030682259 860 2891488 YIL048W NEO1
SGTC_424 splitomicin 100 mM -0.733979387770073 0.225817615346561 no 2631 0.231480650333267 857 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_345 1362-0200 395 µM -0.734283731847222 0.225722888325012 no 2632 0.231387915349754 851 1419823
SGTC_287 k060-0039 29.6 µM -0.734615271596566 0.225619722243784 no 2633 0.231286917306861 848 5861974
SGTC_1496 4469-0713 57.4 µM -0.734745142106214 0.225579317375317 no 2634 0.231247361130903 851 746691
SGTC_2487 5918373 44.05 µM -0.735842768573237 0.225237991183593 no 2635 0.230913195017928 844 2876279
SGTC_3309 9129340 25.759 µM -0.736549137396155 0.225018488202599 no 2636 0.230698287727069 846 17158987
SGTC_2625 euphol 100 µM -0.739537068236205 0.224091335560869 no 2637 0.229790469755459 839 6708538 A triterpene alcohol.
SGTC_1249 0481-0015 10.2 µM -0.739919685371 0.223972766681349 no 2638 0.229674364486634 864 4227577
SGTC_3310 9130229 44.1445 µM -0.741526192955913 0.223475316702844 no 2639 0.229187228127606 862 7761258
SGTC_132 0417-1715 25.805 µM -0.74289134922383 0.223053094821009 no 2640 0.228773731778559 853 6769098
SGTC_1182 1222-0449 220 µM -0.743715387583514 0.222798452425556 no 2641 0.228524339122286 853 658318
SGTC_2172 5754775 163.918 µM -0.743903078139062 0.222740475902208 no 2642 0.228467556518679 842 2263357
SGTC_821 1114-0266 29.2 µM -0.744175540590163 0.222656329134195 no 2643 0.228385141718966 840 3123235
SGTC_2696 st077691 74.316 µM -0.745962884514087 0.222104778875032 no 2644 0.227844918027466 865 757133
SGTC_3224 9130643 49.47 µM -0.746591055064634 0.221911119269373 no 2645 0.227655224736723 842 17644395
SGTC_2827 7993847 71.43 µM -0.746616540409373 0.221903264391662 no 2646 0.227647530616558 821 2985692
SGTC_2032 5185112 25.99 µM -0.74793986609653 0.221495618355737 no 2647 0.227248214895406 820 5718189
SGTC_2491 paeonol 100 µM -0.749654843507878 0.220967962753749 no 2648 0.226731305368972 864 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2200 6600604 21.907 µM -0.751107140867916 0.220521690403476 no 2649 0.226294089269569 884 2904777
SGTC_1242 0402-0103 60.1 µM -0.752090941658845 0.220219674693828 no 2650 0.225998185494233 854 432868
SGTC_2989 9073649 71.4286 µM -0.75363689701025 0.21974556343497 no 2651 0.225533641284019 859 21367202
SGTC_1377 2944-0135 198 µM -0.753762607556554 0.219707036493671 no 2652 0.225495890289475 847 1894137
SGTC_775 4577-0580 57.3 µM -0.754926270672547 0.219350588831862 no 2653 0.225146611005353 854 2006902
SGTC_916 4466-0038 42 nM -0.755359680262346 0.219217913884585 no 2654 0.225016599334464 864 5722064 YGL116W CDC20
SGTC_861 0443-0273 110 µM -0.755885124875356 0.219057127140998 no 2655 0.2248590366083 865 6149169
SGTC_2026 5148700 152 µM -0.758252061451069 0.218333682778197 no 2656 0.224150049918104 864 79838
SGTC_1791 st048313 56.1 µM -0.758585246206095 0.218231956861318 no 2657 0.224050350564492 828 1204976
SGTC_64 000l-0018 272.079 µM -0.759605278907021 0.21792069660285 no 2658 0.223745281373954 854 6811119
SGTC_2576 guaiol 23.12 µM -0.759897879541557 0.217831457571855 no 2659 0.223657814609061 835 227829
SGTC_2210 7115885 190.385 µM -0.761381769214787 0.217379216942778 no 2660 0.223214536644095 863 2927039
SGTC_1626 st003712 1.76 µM -0.761577566630318 0.217319584860467 no 2661 0.223156084033288 876 24207035
SGTC_1087 pterostilbene 9.05 µM -0.762197969637985 0.217130697253393 no 2662 0.222970928858953 876 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1339 1486-1321 22.7 µM -0.763533208092573 0.216724493088778 no 2663 0.222572732736078 862 3469382
SGTC_2888 9058547 12.99 µM -0.765254293352755 0.216201556074802 no 2664 0.222060067614036 851 16476514
SGTC_2563 tomatine 8.54 µM -0.766594757387328 0.215794774169014 no 2665 0.221661246741919 882 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_228 caffeine 993.056 µM -0.767029673931085 0.215662888246931 no 2666 0.221531936416904 835 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3329 9141233 27.5565 µM -0.767365097150396 0.21556120502627 no 2667 0.221432237119845 853 4909101 YNL103W MET4
SGTC_2425 5628681 7.85 µM -0.767921571322216 0.215392571765421 no 2668 0.221266890487067 868 5714958
SGTC_487 nimodipine 119 µM -0.768402377862293 0.215246930384388 no 2669 0.221124084062499 845 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2342 7990637 118.86 µM -0.770180922506303 0.214708687392662 no 2670 0.220596289414081 872 2033102 YER133W GLC7
SGTC_467 ro 31-8220 72.8 µM -0.770500151531383 0.214612161606207 no 2671 0.220501632588807 858 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1026 k007-1105 30.6 µM -0.770551240746608 0.214596716020871 no 2672 0.220486485930025 853 7066794
SGTC_2363 9053361 176 µM -0.770650420130808 0.214566733383887 no 2673 0.220457083456074 856 6469797 YMR079W SEC14
SGTC_2440 5628896 157.78 µM -0.772026295708065 0.21415104763529 no 2674 0.220049426676211 871 5522048
SGTC_3176 9106582 49.47 µM -0.773648292889774 0.213661604860726 no 2675 0.219569402640017 817 17018027
SGTC_3089 9117425 49.47 µM -0.774135422242353 0.213514739382218 no 2676 0.219425356040053 871 9401657
SGTC_2799 7812892 81.82 µM -0.779447017921193 0.211917159215964 no 2677 0.217858218087823 867 20205235
SGTC_113 0099-0221 2.5 µM -0.779993936999391 0.211753059182272 no 2678 0.217697221961527 853 89219
SGTC_2466 5983409 37.09 µM -0.780363105379292 0.211642334308641 no 2679 0.217588588980275 876 2879657
SGTC_1386 3228-0095 33.8 µM -0.780721037467405 0.2115350119076 no 2680 0.217483292312616 851 870181
SGTC_2284 7945075 39.21 µM -0.780941565807721 0.211468904529858 no 2681 0.217418431805509 871 1245402
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.78162982180803 0.211262665097774 no 2682 0.21721607780252 885 689007
SGTC_3039 9090270 49.47 µM -0.782435654436391 0.21102134304788 no 2683 0.216979293427169 839 17173750
SGTC_718 1130-0073 349 µM -0.784669510672717 0.210353217352771 no 2684 0.21632368173128 878 6740020
SGTC_2995 9067767 71.4286 µM -0.7867432654632 0.209734089599182 no 2685 0.21571608567159 861 11673567
SGTC_2220 6782180 200 µM -0.787643078258589 0.209465780563959 no 2686 0.215452754711188 852 833803
SGTC_220 paclitaxel 373.376 µM -0.787769878239497 0.209427987183712 no 2687 0.215415661587391 841 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1922 5578187 25 µM -0.788265447244449 0.209280318805148 no 2688 0.215270727053238 825 1350412
SGTC_1662 st014054 52 µM -0.788285654506187 0.209274298797939 no 2689 0.215264818421274 871 2838777
SGTC_2116 5511452 16.8835 µM -0.78997076100004 0.208772642307912 no 2690 0.214772422160742 873 870744
SGTC_2088 5278280 127.392 µM -0.791642700453331 0.208275606693622 no 2691 0.214284520748513 876 791502
SGTC_3068 9116768 49.47 µM -0.792247146397226 0.208096088435723 no 2692 0.214108291565621 866 41904888
SGTC_1796 st049173 110.4 µM -0.793233827553506 0.207803243996087 no 2693 0.213820801111727 882 94134
SGTC_1391 3442-0225 151 µM -0.793725627416824 0.207657369996961 no 2694 0.213677588792928 856 5227075
SGTC_1103 duloxetine 36.1 µM -0.793776554705605 0.2076422677829 no 2695 0.213662761939245 876 60835 A selective serotonin reuptake inhibitor.
SGTC_2595 hexamethylquercetagetin 100 µM -0.794828945549395 0.207330332214722 no 2696 0.213356505475069 898 386331
SGTC_1746 st038117 42 µM -0.795035340386366 0.207269187942071 no 2697 0.213296472504019 846 2898218
SGTC_864 0469-0573 172 µM -0.797482239300345 0.206545109419606 no 2698 0.212585506867314 902 689425
SGTC_3328 9140624 29.0385 µM -0.797686863336299 0.206484625691857 no 2699 0.212526114529067 863 4904392
SGTC_200 k038-0079 37.545 µM -0.799579601782521 0.205925658812353 no 2700 0.211977204873919 888 3436683
SGTC_1346 1488-2224 62.4 µM -0.799951014565303 0.205816077971888 no 2701 0.211869589528089 858 3722427
SGTC_1111 tnp00062 510.699 nM -0.801749387470834 0.20528597938333 no 2702 0.211348970527205 867 676306
SGTC_1156 4092-0367 4.88 µM -0.801780722646591 0.205276750044484 no 2703 0.211339905814439 862 1357585
SGTC_2317 5986382 200 µM -0.802050191134948 0.205197392035848 no 2704 0.21126196274175 908 877883
SGTC_435 c-PAF 6.7 µM -0.802369257157553 0.205103451212477 no 2705 0.211169695488429 855 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1550 gossypolone 36.6 µM -0.802531583322615 0.205055668239233 no 2706 0.21112276320411 876 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2129 girgensonine 121.053 µM -0.80295618684697 0.204930711556421 no 2707 0.211000029323247 874 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2281 7943571 200 µM -0.803153968858258 0.204872521695059 no 2708 0.210942873675517 866 1244024
SGTC_1197 1601-0112 267 µM -0.803160761750061 0.204870523318611 no 2709 0.210940910806214 874 7350313
SGTC_1642 st009582 77.7 µM -0.804541540261493 0.204464557724114 no 2710 0.210542144375021 882 6739311
SGTC_843 0310-0051 143 µM -0.805789709800872 0.2040979931214 no 2711 0.210182056178903 865 2065037
SGTC_2902 5787006 60.46 µM -0.805974751308589 0.204043683148221 no 2712 0.210128703801054 869 591003
SGTC_565 1418-0001 44.5 µM -0.806124336909432 0.203999785833209 no 2713 0.210085580117761 885 2862145
SGTC_1493 4348-0038 111 µM -0.806774485409147 0.203809058967033 no 2714 0.209898210743474 887 800424
SGTC_2684 capsaicin 100 µM -0.807010742755238 0.203739777104295 no 2715 0.209830146958414 878 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_466 geldanamycin 89.2 µM -0.807947936909846 0.203465085663426 no 2716 0.209560276926057 845 5288382 HSP90 inhibitor.
SGTC_787 4152-0075 138 µM -0.808360130359223 0.203344341821982 no 2717 0.209441648306415 855 9566539
SGTC_1189 1431-2119 7.28 µM -0.809823075229438 0.202916146625686 no 2718 0.209020934190786 874 3107275
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.81115362882513 0.202527169609177 no 2719 0.208638725745116 880 4213774
SGTC_332 4112-0506 40.9 µM -0.812154121333536 0.202234977211654 no 2720 0.208351600615556 879 2790355
SGTC_3302 9125395 16.351 µM -0.813196186563801 0.201930911832007 no 2721 0.208052792737104 854 17599668
SGTC_1042 0350-0096 82 µM -0.813379029814423 0.20187758803172 no 2722 0.208000389292215 876 3122515
SGTC_529 4076-0302 30.3 µM -0.814530808886936 0.201541880854228 no 2723 0.207670465007359 885 5816522
SGTC_2618 avocadyne 43.43 µM -0.814957481094071 0.201417604351022 no 2724 0.207548324325915 874 3015189
SGTC_1313 1220-0047 237 µM -0.815007603405944 0.201403008276828 no 2725 0.207533978924236 878 3528706
SGTC_82 0054-0107 293.755 µM -0.815120058966156 0.201370262499232 no 2726 0.207501795386691 870 3104697
SGTC_3352 9151559 45.5865 µM -0.816163818496674 0.201066483909926 no 2727 0.207203223726205 856 17159339
SGTC_3102 9121669 49.47 µM -0.816278001043301 0.201033268601027 no 2728 0.207170576769761 890 41905072
SGTC_1270 0831-1170 17.3 µM -0.817936545921466 0.20055117483092 no 2729 0.206696710477517 868 6764716
SGTC_1924 st058459 75.1 µM -0.818204552853214 0.20047333773022 no 2730 0.206620197941354 861 688683
SGTC_822 1487-0950 154 µM -0.818209933927176 0.200471775093799 no 2731 0.206618661885656 865 1958375
SGTC_2192 5915882 198.485 µM -0.818246796567129 0.200461070567968 no 2732 0.206608139434196 859 2876149
SGTC_752 1896-0090 130 µM -0.820373886988314 0.199843967319279 no 2733 0.206001498537709 869 772567
SGTC_2983 9022671 12.99 µM -0.821329356143636 0.199567142595173 no 2734 0.205729345310219 868 6405161
SGTC_2649 anisomycin 9.56 µM -0.824512705439035 0.198646508612202 no 2735 0.204824149777973 874 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3313 9133968 57.047 µM -0.825001424014994 0.198505396897079 no 2736 0.204685391117261 873 1494643
SGTC_1688 st021091 57.6 µM -0.825611089423345 0.198329448009087 no 2737 0.204512371228999 893 3656366
SGTC_1502 4534-4282 27.7 µM -0.826297267187961 0.198131530342116 no 2738 0.204317741673878 893 3278949
SGTC_1455 4262-0120 131 µM -0.829044162437787 0.197340424612769 no 2739 0.203539709004729 896 1529587
SGTC_17 0960-0276 49.807 µM -0.830172456668799 0.197016030233455 no 2740 0.203220642768677 875 6821114
SGTC_577 r071-0003 38.6 µM -0.832178078656989 0.196440193890772 no 2741 0.202654217721918 903 4568517 YMR134W ERG29
SGTC_1231 0242-0792 125 µM -0.832989517902648 0.196207510787138 no 2742 0.202425320501142 888 3707635
SGTC_2390 9097792 176.6 µM -0.833523010233202 0.196054621051551 no 2743 0.202274913019192 863 4497149
SGTC_401 neomycin 50 µM -0.835102769290252 0.195602313237323 no 2744 0.201829923800135 854 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1737 st035557 69.7 µM -0.836153602973894 0.195301795583834 no 2745 0.201534248074376 878 5716916
SGTC_2839 9003951 25.97 µM -0.842325298374647 0.193542481076385 no 2746 0.1998029470705 856 2990634
SGTC_608 k048-0125 159 µM -0.843949184710435 0.193081184383831 no 2747 0.199348900959491 880 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.844881306745911 0.192816700389875 no 2748 0.199088556226668 882 688803
SGTC_1974 st069448 26.9 µM -0.845952390531798 0.192513060268365 no 2749 0.198789652084265 861 6323587 YNR016C ACC1
SGTC_817 1391-0715 46 µM -0.84605419311674 0.192484215608119 no 2750 0.198761256428203 892 1353946
SGTC_741 4582-0002 126 µM -0.847445296425315 0.192090326327345 no 2751 0.198373482954955 883 2912688
SGTC_439 amiodarone 34.4 µM -0.848749545204789 0.191721478124669 no 2752 0.198010335365049 886 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1363 1636-0063 10.4 µM -0.848985923969867 0.191654675460865 no 2753 0.197944562411996 868 6072185
SGTC_583 1488-1091 88.9 µM -0.85169069300984 0.190891299770991 no 2754 0.197192893787482 912 4303273
SGTC_3293 9120939 62.045 µM -0.852073703909849 0.190783352343177 no 2755 0.197086592938347 884 934087
SGTC_3090 9117696 49.47 µM -0.852109812283614 0.190773177525939 no 2756 0.197076573209006 860 7923821
SGTC_1472 k841-0093 193 µM -0.852754241576566 0.190591642682892 no 2757 0.19689780207804 896 X1472
SGTC_1029 k015-0030 64.7 µM -0.854566018365062 0.190081836097064 no 2758 0.196395723360724 876 2208316
SGTC_2898 9056270 58.44 µM -0.854654836604684 0.19005686555555 no 2759 0.196371130061775 826 19154699
SGTC_1803 st050068 52.4 µM -0.854874147894246 0.189995216566704 no 2760 0.196310411925932 900 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2845 9003024 42.97 µM -0.855873844088986 0.189714355046183 no 2761 0.196033782016264 874 2990173
SGTC_1904 st060225 78 µM -0.856137693031009 0.189640270124787 no 2762 0.19596081078449 870 66595
SGTC_1378 2093-0007 380 nM -0.857326275270998 0.189306754339045 no 2763 0.195632295591755 904 3618014
SGTC_2811 7967822 32.47 µM -0.857675296679863 0.189208887669016 no 2764 0.195535892243857 887 2232244
SGTC_3343 9148379 18.9835 µM -0.857687155590444 0.189205562941551 no 2765 0.195532617196082 862 1955036
SGTC_3173 9105693 49.47 µM -0.859560038596716 0.188680938779036 no 2766 0.19501580558222 907 17096658
SGTC_763 3453-1109 128 µM -0.861109754009398 0.188247517632188 no 2767 0.194588798771941 873 1560353
SGTC_2736 butenafine 14.65 µM -0.861421724104471 0.188160340828848 no 2768 0.194502907736494 887 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_391 gliotoxin 8.33 µM -0.865402877555542 0.18705003750969 no 2769 0.193408851084169 914 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3153 9100258 49.47 µM -0.867786542990698 0.186387201274946 no 2770 0.192755599132098 904 25236848
SGTC_2247 cerulenin 830 nM -0.869937820366581 0.185790237051634 no 2771 0.192167192801793 870 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1884 5633444 25 µM -0.871971266415889 0.185227061781749 no 2772 0.191612026500455 885 5724239
SGTC_1898 st060199 18.6 µM -0.874816705485899 0.184440781932277 no 2773 0.190836823040019 870 688866
SGTC_2751 anetholtrithion 17.25 µM -0.87570995543423 0.184194379100715 no 2774 0.190593865924297 912 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2858 9025781 8.96 µM -0.876483467122549 0.183981171650158 no 2775 0.190383630174719 869 4894980 YPL153C RAD53
SGTC_2711 st079103 59.1 µM -0.878186299127238 0.183512352102797 no 2776 0.18992131298215 905 54693780
SGTC_2077 5212015 200 µM -0.878407393072992 0.183451535720054 no 2777 0.189861336861341 876 780900
SGTC_1856 st057054 55.7 µM -0.879023646407165 0.183282089040571 no 2778 0.189694227389671 894 1266018
SGTC_3230 9131665 49.47 µM -0.879918437759947 0.183036228597418 no 2779 0.18945174784183 880 15943720
SGTC_1936 st074407 74.3 µM -0.880380411450555 0.182909373379012 no 2780 0.189326632267759 906 809813
SGTC_1131 3454-3128 32.3 µM -0.880724944587983 0.182814802363343 no 2781 0.189233356044641 879 710982
SGTC_2531 methyl deoxycholate 70.07 µM -0.88236410057569 0.182365288041617 no 2782 0.188789971333378 921 16667744 Haematoxylin.
SGTC_2877 9040724 71.43 µM -0.882567470863941 0.182309564938994 no 2783 0.188735005216842 909 6463895
SGTC_492 tmb-8 126 µM -0.884263929233183 0.181845152954317 no 2784 0.188276877576661 885 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_689 0833-0039 98 µM -0.885397986580039 0.181535113452014 no 2785 0.187971008977091 929 5374726
SGTC_1334 1486-0610 236 µM -0.888073494711436 0.180804969320339 no 2786 0.187250609517508 867 3742339
SGTC_3287 9117173 37.0625 µM -0.888221671010238 0.180764585992972 no 2787 0.187210761957454 869 2789709
SGTC_2105 5350118 200 µM -0.888926425015968 0.180572592798672 no 2788 0.187021311347527 900 2133313
SGTC_988 1497-1057 103 µM -0.888998639643924 0.180552926895112 no 2789 0.187001905452187 890 3533044
SGTC_770 0389-1121 67.2 µM -0.8891612162586 0.180508658011181 no 2790 0.186958221567046 897 6753108
SGTC_917 harmaline 728.087 nM -0.889855142783957 0.180319781483282 no 2791 0.186771836433103 873 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_788 1182-0090 188 µM -0.891011825234779 0.18000522539763 no 2792 0.18646141315141 893 5715185
SGTC_2041 5107442 45.335 µM -0.892773778975532 0.179526730345484 no 2793 0.185989165464931 891 793005
SGTC_839 0122-0028 230 µM -0.892862284895125 0.179502715835645 no 2794 0.185965463240881 895 759448
SGTC_800 3448-7362 155 µM -0.895215738554834 0.178864888808789 no 2795 0.185335886525053 904 15991913
SGTC_2819 7996655 46.38 µM -0.89634497685099 0.178559352589938 no 2796 0.18503427228746 873 6456960
SGTC_1805 st050013 60.3 µM -0.896558437970452 0.178501633715035 no 2797 0.184977292115874 888 4037144
SGTC_1825 st052143 62.6 µM -0.896700732142366 0.178463164574288 no 2798 0.184939314926185 917 674173
SGTC_342 k048-0088 23.3 µM -0.89697454643237 0.178389153746806 no 2799 0.184866249689635 903 6820570
SGTC_959 1222-0044 107 µM -0.901474797249215 0.177175527046384 no 2800 0.183667964013239 889 6083612
SGTC_1613 st002381 52.1 µM -0.902062498863276 0.177017421685858 no 2801 0.183511834250048 901 551167
SGTC_2572 astragaloside iv 100 µM -0.902302073954487 0.17695299601613 no 2802 0.183448212084257 897 45006101 An anti-inflammatory agent.
SGTC_224 benfluorex 43.875 µM -0.903338594809446 0.176674429326224 no 2803 0.183173109452987 912 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1991 st073000 8.92 µM -0.903721456579028 0.176571604756734 no 2804 0.183071559358232 913 4301969 YIL048W NEO1
SGTC_149 3970-0822 46.1 µM -0.905246614391517 0.17616237135225 no 2805 0.18266737587906 896 3114250 YBL034C STU1
SGTC_2159 5658611 73.75 µM -0.905426351278717 0.176114183564182 no 2806 0.182619780368697 915 793844
SGTC_678 1218-2179 85.9 µM -0.906373155560525 0.175860481371129 no 2807 0.182369188228381 919 6820081 YOR116C RPO31
SGTC_1983 st071813 46.9 µM -0.906502390096987 0.175825870122612 no 2808 0.182335000197302 906 11838595
SGTC_1273 0849-0096 14.1 µM -0.909825644662904 0.1749373273068 no 2809 0.181457233956535 914 5286025
SGTC_952 1185-0122 232 µM -0.911492188499186 0.174492815986601 no 2810 0.181018049799303 900 678600
SGTC_803 4488-1585 147 µM -0.91199336118207 0.174359280406743 no 2811 0.180886106175441 894 747204
SGTC_3010 9080089 71.4286 µM -0.914886134903347 0.173589781081661 no 2812 0.180125704808428 899 17027233
SGTC_2202 7226349 200 µM -0.915754556815569 0.173359196778041 no 2813 0.17989782155203 893 844334
SGTC_2714 st079313 56.9 µM -0.916892390289815 0.173057373293136 no 2814 0.179599515978372 901 2939799
SGTC_2307 7538926 6.34 µM -0.921191764436045 0.171919938960546 no 2815 0.178475158612762 912 96582
SGTC_1756 st041558 35.5 µM -0.921532243697378 0.171830066839674 no 2816 0.178386307532569 944 3955792
SGTC_2669 eugenol 100 µM -0.923405993705782 0.17133601313379 no 2817 0.177897834697332 894 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_987 1497-1013 404 µM -0.923618379983454 0.171280070367372 no 2818 0.177842520435859 904 1676435
SGTC_2944 9067346 25.62 µM -0.925599961116366 0.170758682703879 no 2819 0.177326956799922 909 6473075
SGTC_2097 5376186 200 µM -0.931234826434508 0.169281611880405 no 2820 0.175866053267849 905 742755
SGTC_2103 5378138 10 µM -0.932211744688598 0.169026368397338 no 2821 0.175613553507567 899 244142
SGTC_1725 st036284 20.55 µM -0.932686727067842 0.168902357135277 no 2822 0.175490869944325 903 707914
SGTC_2729 fluphenazine 10.66 µM -0.933499770130881 0.168690218647954 no 2823 0.175280994541625 897 3372 An atypical antipsychotic.
SGTC_485 niflumic acid 177 µM -0.935796644981489 0.168091845737713 no 2824 0.174688949615684 925 4488 A COX2 inhibitor.
SGTC_3276 9139060 49.47 µM -0.937131521791612 0.167744717140907 no 2825 0.174345454374576 928 4870619
SGTC_1370 2001-0092 44.6 µM -0.937497595187976 0.167649602142645 no 2826 0.174251330095663 899 790957
SGTC_2085 5307070 144.047 µM -0.937880247671059 0.167550216622523 no 2827 0.174152977549649 931 2840351
SGTC_2496 diffractaic acid 79.83 µM -0.938435974797226 0.167405946391895 no 2828 0.174010202753336 916 94870 An apoptosis inducer which activates caspases.
SGTC_2978 9011784 42.97 µM -0.939179163114384 0.167213135209367 no 2829 0.173819382652066 890 2994934
SGTC_1620 st003704 16.5 µM -0.939377480219694 0.167161708451275 no 2830 0.173768485504838 897 2834414
SGTC_1872 amphotericin b 148 nM -0.94341184918825 0.166117746898127 no 2831 0.172735142344991 902 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2857 9024691 58.44 µM -0.943846507653918 0.1660055235164 no 2832 0.172624045306609 925 16478292
SGTC_3131 9127911 49.47 µM -0.944503161778821 0.165836076565127 no 2833 0.172456293450699 903 45595681
SGTC_1684 st024538 14.6195 µM -0.944686996519522 0.165788658789271 no 2834 0.172409348824529 922 6732859
SGTC_3201 9113999 49.47 µM -0.944843835440288 0.165748211162906 no 2835 0.172369304381327 929 16649224
SGTC_3096 9117468 49.47 µM -0.945934716809146 0.165467057256246 no 2836 0.172090942426227 897 41316311
SGTC_2421 5690543 90.72 µM -0.94831425987652 0.164854846427342 no 2837 0.171484746766963 919 3397993
SGTC_2667 digitoxin 100 µM -0.948456665773787 0.164818254704217 no 2838 0.171448511771217 869 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1304 1165-0502 251 µM -0.948501120870419 0.164806832879931 no 2839 0.171437201231871 904 767425
SGTC_938 3126-1755 342 µM -0.950138623529517 0.164386467478749 no 2840 0.171020910064387 900 1777771
SGTC_2187 6125751 200 µM -0.952646519528409 0.163744011013466 no 2841 0.170384599366653 919 874498
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.953266310085213 0.163585488610252 no 2842 0.170227578279339 923 616764
SGTC_3166 9102297 49.47 µM -0.95392065338083 0.163418236906895 no 2843 0.170061904059073 919 25237072
SGTC_552 k242-0005 476 µM -0.956113465474405 0.162858559013672 no 2844 0.169507456229197 931 4088318
SGTC_1625 st003711 30.1 µM -0.957242437510455 0.162570894785177 no 2845 0.169222450892336 920 24207034 YER133W GLC7
SGTC_2361 9034121 116 µM -0.95900260718769 0.162123060118897 no 2846 0.168778715880888 939 6496917
SGTC_1711 st032263 62.8 µM -0.959668817321955 0.161953768059198 no 2847 0.168610960961924 925 3958979
SGTC_568 1193-0097 7.48 µM -0.96091011951581 0.161638645435419 no 2848 0.168298681095307 875 3646150
SGTC_2341 7987486 176.74 µM -0.961311919976295 0.161536728223616 no 2849 0.168197678130738 890 1258686
SGTC_2086 5274770 176.623 µM -0.96395537914753 0.160867256129776 no 2850 0.167534148637092 906 689278
SGTC_1063 disulfiram 1.84 µM -0.963987054950038 0.160859245038285 no 2851 0.16752620799393 936 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_920 mycophenolic acid 780.421 nM -0.964828908095119 0.160646428355463 no 2852 0.167315257037109 933 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_443 clozapine 122 µM -0.965534220662461 0.160468270150394 no 2853 0.167138652178142 928 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1893 st059353 36.1 µM -0.965642707980451 0.160440878289729 no 2854 0.167111498453981 961 3112488
SGTC_2522 biochanin a 4.94 µM -0.968307832426581 0.159768922987959 no 2855 0.166445327121808 917 5280373 A possible chelator.
SGTC_3114 9122766 49.47 µM -0.96911556484315 0.159565634281164 no 2856 0.166243766311569 884 17176985
SGTC_2967 9089538 49.85 µM -0.970283166706879 0.159272073621839 no 2857 0.165952682782168 922 728216
SGTC_2634 4'-methoxyflavone 100 µM -0.970392176614095 0.159244684209198 no 2858 0.165925523397728 931 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_477 mead ethanolamide 10 µM -0.970725750576633 0.159160890853445 no 2859 0.165842432618719 911 16061185
SGTC_2694 st077685 81.9 µM -0.97096475406086 0.159100871244792 no 2860 0.165782915180742 922 2838096
SGTC_3254 9136651 49.47 µM -0.972682886938228 0.158669842615551 no 2861 0.165355466543358 938 16454030
SGTC_1225 1216-0074 20.6 µM -0.97536541237098 0.157998408764048 no 2862 0.164689517014739 928 4241466
SGTC_904 1141-0088 396 µM -0.97550698212472 0.157963025869626 no 2863 0.16465441999798 951 1378119
SGTC_3052 9092717 49.47 µM -0.975872367114905 0.157871728298207 no 2864 0.164563858617217 939 25237534
SGTC_2186 6124449 200 µM -0.9773239417439 0.157509370359717 no 2865 0.164204401932494 910 3834182 YLR033W RSC58
SGTC_187 1488-2104 32.728 µM -0.979474119906571 0.156973624578348 no 2866 0.163672884970428 909 2852859
SGTC_1163 k060-0048 49.9 µM -0.979843262073209 0.156881768556551 no 2867 0.163581746706574 919 6809982
SGTC_1525 8-methoxypsoralen 92.5 µM -0.980894390766426 0.15662040320531 no 2868 0.163322411940856 952 4114 Related to psoralen; DNA damaging agent.
SGTC_1507 4075-3230 155 µM -0.981368833997152 0.156502525846113 no 2869 0.163205444710079 906 659771
SGTC_1074 carmofur 3.8 µM -0.986620081123907 0.155201734354443 no 2870 0.161914461017196 930 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_478 N-arachidonylglycine 10 µM -0.98694291200747 0.15512199914359 no 2871 0.161835312883121 916 5283389
SGTC_2448 5185112 27.17 µM -0.987070711886256 0.155090441637672 no 2872 0.161803987277414 906 5718189
SGTC_2543 pimpinellin 60.67 µM -0.987270848306722 0.155041030653676 no 2873 0.16175493887433 916 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2511 berberine 10.47 µM -0.991141445700393 0.154087476977781 no 2874 0.160808258812547 921 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3049 9092223 49.47 µM -0.991460816761568 0.154008970915768 no 2875 0.160730308147413 930 8623917
SGTC_1274 0865-0114 173 µM -0.993068826170733 0.153614100895271 no 2876 0.160338207316525 909 870624
SGTC_629 3448-6466 76.7 µM -0.996696815981553 0.152725659980434 no 2877 0.15945584783349 932 573744
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.997196309356398 0.152603608914999 no 2878 0.159334616013936 933 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_901 1112-0062 60.1 µM -1.00079800873032 0.151725450699514 no 2879 0.15846223622645 911 1908457
SGTC_2064 5220758 200 µM -1.00107872940454 0.151657147376684 no 2880 0.158394373781333 928 788518
SGTC_2152 5568786 200 µM -1.00208801510278 0.151411742700319 no 2881 0.158150542876686 927 5399883
SGTC_107 0358-0022 2.6945 µM -1.00229287032623 0.151361965046042 no 2882 0.158101082487653 963 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1646 st011709 75.6 µM -1.00468865730885 0.150780622083561 no 2883 0.157523395798278 937 5757843
SGTC_600 1495-0418 41.6 µM -1.00604767531674 0.150451515042367 no 2884 0.157196318490687 940 5377768
SGTC_643 k048-0106 28.4 µM -1.00607813206966 0.150444144959595 no 2885 0.157188993529002 938 6763920
SGTC_2204 7233102 200 µM -1.00660035470522 0.150317812241358 no 2886 0.157063431971995 907 2172480
SGTC_1553 gossypol 38.6 µM -1.00828615571056 0.1499104767383 no 2887 0.156658553636313 899 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2334 9017922 200 µM -1.00840676886275 0.149881361555137 no 2888 0.15662961236911 931 3163164
SGTC_1900 st060200 72.8 µM -1.00998927249461 0.149499705447988 no 2889 0.156250214820869 930 688945
SGTC_3048 9093155 49.47 µM -1.01091630466056 0.149276432464708 no 2890 0.15602824480424 881 25236002
SGTC_538 2922-0838 53.3 µM -1.01283664895752 0.148814631798157 no 2891 0.155569096051049 956 777039
SGTC_795 0685-0265 78 µM -1.01583653726503 0.148095137062412 no 2892 0.154853616905644 922 302754
SGTC_2408 sulbentine 18.36 µM -1.0164979119958 0.147936826327052 no 2893 0.154696170652944 911 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1175 0741-0056 27.6 µM -1.01753306887013 0.147689272283512 no 2894 0.154449954584348 932 765927
SGTC_1165 k072-0275 30.3 µM -1.02062559070983 0.146951360102718 no 2895 0.153715930156626 933 6153523 YGL055W OLE1
SGTC_2076 5212012 200 µM -1.02123578525575 0.146806053074359 no 2896 0.153571370890931 934 604802
SGTC_2063 5246145 200 µM -1.0220332425162 0.146616298091711 no 2897 0.153382583556047 944 711240
SGTC_991 3996-0057 64.7 µM -1.02245651611181 0.146515647023184 no 2898 0.153282441680239 921 715343
SGTC_1125 tnp00248 1.32998 µM -1.02274087259452 0.146448055381428 no 2899 0.153215190397402 930 24207736
SGTC_328 k915-0120 63.5 µM -1.02567051720149 0.145752896633914 no 2900 0.152523457958618 929 6624543
SGTC_6 0844-0013 19.835 µM -1.02783464644263 0.145240809386282 no 2901 0.152013807861241 954 1584900
SGTC_684 1140-0066 328 µM -1.02858207851582 0.145064229802283 no 2902 0.151838051508072 929 6813534
SGTC_1454 4239-0054 42.6 µM -1.02868534185472 0.145039845375672 no 2903 0.151813780071098 923 1340767
SGTC_3266 9136860 49.47 µM -1.02941089622113 0.144868592017894 no 2904 0.151643315503845 904 4871271 YPR165W RHO1
SGTC_3303 9125618 40.5795 µM -1.03202240520495 0.14425332210553 no 2905 0.151030810834713 913 22695467
SGTC_705 1124-0212 310 µM -1.03759536896531 0.142946233174035 no 2906 0.149729237424848 922 9554485
SGTC_354 2783-3500 4.88 µM -1.03828641800982 0.142784713308568 no 2907 0.149568365006773 932 6740761
SGTC_2532 xanthone 78.9 µM -1.03946156161245 0.142510328715038 no 2908 0.149295062976368 947 7020 An insecticide.
SGTC_2957 9076800 11.52 µM -1.04150185081374 0.142034788595777 no 2909 0.148821347333192 969 16459615
SGTC_2365 9042475 200 µM -1.04173078698971 0.141981496434003 no 2910 0.148768255535553 920 6464479
SGTC_1945 st075991 56.6 µM -1.04345495735543 0.14158057595239 no 2911 0.148368815843445 952 1084980
SGTC_1148 3909-7663 27.7 µM -1.04354361114157 0.141559982084942 no 2912 0.148348296770746 968 4084526
SGTC_2986 9022445 71.43 µM -1.04376960524622 0.141507493873732 no 2913 0.148295998629909 908 6459286
SGTC_811 0416-0114 265 µM -1.04495864494564 0.141231550953008 no 2914 0.148021041678718 907 6612453
SGTC_465 cgp-37157 41 µM -1.04572174554313 0.141054648920977 no 2915 0.147844759980349 907 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3312 9133330 71.43 µM -1.04688353786514 0.140785610805272 no 2916 0.147576647643523 957 17617324
SGTC_305 1682-2595 20.8 µM -1.04762827013332 0.140613335202278 no 2917 0.147404953649637 926 226033
SGTC_3261 9137475 49.47 µM -1.04837872099733 0.140439881535206 no 2918 0.147232076714517 892 17027690
SGTC_1359 1582-0056 520 nM -1.04909533039418 0.14027438538244 no 2919 0.14706712253882 965 3661189
SGTC_831 k061-1017 217 µM -1.05106566260632 0.139820033290321 no 2920 0.146614216627804 969 1240153
SGTC_1826 st055655 41.6 µM -1.05198484336742 0.139608415813563 no 2921 0.146403251765984 951 676168
SGTC_2741 miltefosine 3.04 µM -1.05225455235094 0.139546363681713 no 2922 0.146341388468173 909 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1246 0422-0085 105 µM -1.05526607532381 0.138854774512374 no 2923 0.145651825987948 934 264295
SGTC_1221 2958-7315 257 µM -1.05655634354033 0.138559182875284 no 2924 0.145357056802112 948 4562705
SGTC_2863 9028737 58.44 µM -1.05935008116775 0.137920626708816 no 2925 0.144720187386509 933 6460917
SGTC_2753 fluvastatin 17.09 µM -1.06081696311729 0.13758615091576 no 2926 0.144386545825802 959 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_746 1095-0025 46.6 µM -1.06089886425287 0.137567492299375 no 2927 0.144367932745669 945 6749286
SGTC_140 0062-0056 502.533 µM -1.06303005618529 0.137082573963095 no 2928 0.14388416064547 950 3758964
SGTC_1912 st060209 90.8 µM -1.06616320457822 0.136371799312054 no 2929 0.14317493610052 955 688787
SGTC_2058 5236698 133 µM -1.07079424290017 0.135325843337261 no 2930 0.142130978052894 925 766665
SGTC_1808 st050063 61.5 µM -1.07111731307679 0.135253081173128 no 2931 0.14205834225437 951 4011993
SGTC_793 0488-0545 106 µM -1.07298194869545 0.134833650359079 no 2932 0.141639607691726 949 292548
SGTC_198 3454-2873 16.191 µM -1.07600956126168 0.134154522205427 no 2933 0.14096149016371 937 710957
SGTC_1719 st032227 49.2 µM -1.07622599025718 0.134106064853898 no 2934 0.140913099385549 934 3125804
SGTC_1193 1488-0126 41.5 µM -1.07654555341193 0.134034538275674 no 2935 0.140841669723044 926 1384710
SGTC_597 k018-0003 82.8 µM -1.07697291088238 0.133938925487164 no 2936 0.140746183967827 954 6786234
SGTC_333 3486-0131 40.1 µM -1.079791296202 0.133309541360497 no 2937 0.14011756395667 924 6744690
SGTC_967 1306-0166 352 µM -1.08117980040407 0.133000218650122 no 2938 0.139808570746444 938 4437607
SGTC_254 nsc-64875 3.808 µM -1.08316584581634 0.132558638625486 no 2939 0.139367408287199 953 56993
SGTC_810 3825-7150 143 µM -1.08384596483703 0.13240765248331 no 2940 0.139216550624671 920 22330411 YGL099W LSG1
SGTC_155 k072-0202 43.6 µM -1.0845257701142 0.13225685446844 no 2941 0.139065873639777 936 5857737
SGTC_2740 felodipine 17.08 µM -1.08492416073537 0.132168536386668 no 2942 0.138977623054587 937 3333 L-type calcium channel blocker
SGTC_3024 9090631 49.47 µM -1.08497761797669 0.132156688697968 no 2943 0.13896578422991 929 25236383
SGTC_3246 9135460 32.98 µM -1.09069741215423 0.130893243908432 no 2944 0.137703024851905 936 41446951
SGTC_1846 st056244 14.8 µM -1.09404315948811 0.130158083670227 no 2945 0.1369680248498 951 5393182
SGTC_2910 7948405 25.97 µM -1.09559935037326 0.129817117627073 no 2946 0.136627073066017 898 2971328
SGTC_863 0466-0191 129 µM -1.09592035778085 0.129746860968636 no 2947 0.136556814598272 958 765160 YPR165W RHO1
SGTC_1777 st045864 34.765 µM -1.09735348397978 0.129433523818677 no 2948 0.13624344957919 978 4691462
SGTC_2174 5790901 200 µM -1.09818665430198 0.129251601581381 no 2949 0.136061496290232 956 786020
SGTC_190 3970-0790 3.722 µM -1.09819744133889 0.129249247401141 no 2950 0.13605914163644 943 2832352
SGTC_2629 bisabolol 100 µM -1.09860922559086 0.129159401167849 no 2951 0.135969275959349 953 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3264 9137442 49.47 µM -1.10151793195462 0.128525990505161 no 2952 0.135335652215066 944 17015726
SGTC_1169 aniline yellow 25.8 µM -1.10182408187974 0.128459447784713 no 2953 0.135269079361041 943 6051 A DNA damaging agent.
SGTC_170 4197-0004 226 µM -1.10263880349614 0.128282481803058 no 2954 0.135092026050623 958 218692
SGTC_1656 st012921 11 µM -1.10729175064833 0.127275057756282 no 2955 0.13408390490221 938 6732821
SGTC_1954 st077032 68.9 µM -1.10788152917533 0.127147757073305 no 2956 0.13395649181336 975 698907
SGTC_2206 7254556 146.969 µM -1.10935392184585 0.126830335397787 no 2957 0.133638765970867 942 4398905
SGTC_1641 st009299 47.1 µM -1.11389396069395 0.125855058662955 no 2958 0.132662340305703 936 4046054
SGTC_3058 9093861 49.47 µM -1.11496703366601 0.125625310799364 no 2959 0.132432274458597 941 17217477
SGTC_2156 5649887 115 µM -1.11550380804358 0.125510495802416 no 2960 0.132317293757187 980 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_965 1291-5240 308 µM -1.11640952982616 0.125316929745537 no 2961 0.132123438068917 974 2834598
SGTC_3108 9121785 49.47 µM -1.1168771487124 0.125217074333877 no 2962 0.132023428195628 904 17140271
SGTC_379 3970-0972 5.9 µM -1.11751471343952 0.125081018193824 no 2963 0.131887156057584 966 2898042 YBL034C STU1
SGTC_1400 3771-8998 51.5 µM -1.11799143084464 0.124979354315258 no 2964 0.13178532660532 952 670767
SGTC_2061 5245884 80.95 µM -1.11841409986022 0.124889264985441 no 2965 0.131695087564352 963 573863
SGTC_2918 7977171 22.06 µM -1.11843493903846 0.124884824415275 no 2966 0.131690639542151 937 2236483
SGTC_497 capsazepine 133 µM -1.12054289948003 0.124436214047035 no 2967 0.13124124108027 966 2733484 A calcium channel blocker.
SGTC_2279 7948423 32.93 µM -1.12093813080633 0.124352227597882 no 2968 0.131157099315932 941 1247112
SGTC_500 h-89 112 µM -1.12127512893602 0.124280646990475 no 2969 0.131085384396258 964 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3297 9117502 71.43 µM -1.12255898224502 0.124008212202148 no 2970 0.130812422072583 945 7453720
SGTC_827 3253-0474 693 µM -1.12401388365587 0.123699986318001 no 2971 0.130503568063387 950 5402065
SGTC_1166 k206-0078 225 µM -1.12607618746319 0.123263999829088 no 2972 0.130066636167705 950 5404595
SGTC_3100 9120536 49.47 µM -1.12821412345556 0.122813162043984 no 2973 0.129614750332652 946 16421196
SGTC_1981 st071826 47 µM -1.13029386431885 0.122375706989623 no 2974 0.129176209553235 933 11838600
SGTC_2977 9011197 71.43 µM -1.13209125096029 0.12199852458526 no 2975 0.128798036378003 928 2704722
SGTC_2168 5727979 200 µM -1.13265567752909 0.121880248044599 no 2976 0.128679438697084 968 695210
SGTC_2831 7999036 19.48 µM -1.13302428641435 0.121803048923704 no 2977 0.128602027270005 980 2988270
SGTC_1352 1496-0991 99 µM -1.13494808709217 0.121400697784685 no 2978 0.128198535051283 980 3000039
SGTC_367 0335-0881 7.1 µM -1.13771102815458 0.120824481763692 no 2979 0.127620583455208 975 23828853
SGTC_402 epigallocatechin gallate 10 µM -1.13997036414985 0.120354726099312 no 2980 0.127149324045533 958 65064 An antioxidant.
SGTC_337 1315-0038 354 µM -1.14304290217601 0.119717958031218 no 2981 0.126510389442239 958 1626437
SGTC_1480 1070-0044 41.2 µM -1.14335133652299 0.11965416802715 no 2982 0.126446374236285 962 3124987
SGTC_2843 9000894 45.46 µM -1.14448756970252 0.119419380541473 no 2983 0.126210745016327 921 2242070
SGTC_3118 9124250 49.47 µM -1.15514277701283 0.117233432749571 no 2984 0.12401598162593 940 1504786
SGTC_1994 st072947 40.9 µM -1.15558747418929 0.117142822005389 no 2985 0.123924966953318 978 5286565 YDL195W SEC31
SGTC_3107 9121808 49.47 µM -1.15714789547414 0.11682526574924 no 2986 0.123605970652059 900 662681
SGTC_1380 2291-0730 164 µM -1.15760391398649 0.116732578237072 no 2987 0.123512855643225 971 2999191
SGTC_1102 cgs 12066b 26.1 µM -1.16077341443065 0.11608980545052 no 2988 0.1228670286233 951 6438352 A 5-HT1B full agonist.
SGTC_1302 1159-0335 255 µM -1.16212422623687 0.115816626522314 no 2989 0.122592504032519 966 649284
SGTC_2583 asiatic acid 100 µM -1.16216871193477 0.115807637810516 no 2990 0.122583470558609 979 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_986 1493-0483 84 µM -1.16334532047166 0.115570073915727 no 2991 0.122344712434682 974 40079
SGTC_3125 9127534 49.47 µM -1.16378976556626 0.115480428099267 no 2992 0.122254610351806 952 1639235
SGTC_2132 5317594 122.667 µM -1.16499696616529 0.115237181774035 no 2993 0.122010110442779 973 794577
SGTC_2446 5162541 200 µM -1.165936061439 0.11504820969063 no 2994 0.121820148771904 974 1549321
SGTC_2710 st078562 53.7235 µM -1.1663608965883 0.114962793478513 no 2995 0.121734280745437 982 17250908
SGTC_646 4092-0839 27.3 µM -1.16788178345651 0.114657377839639 no 2996 0.121427226539014 968 877796
SGTC_2405 ticlatone 3.52 µM -1.16840901922699 0.114551636318521 no 2997 0.121320909298187 976 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1844 rapamycin 4 nM -1.16846923479655 0.114539564002665 no 2998 0.121308770977835 920 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1946 st076057 65.1 µM -1.16849737695297 0.114533922234169 no 2999 0.12130309834401 956 953009
SGTC_2899 9053889 58.44 µM -1.17086794614566 0.114059394791555 no 3000 0.120825930568525 949 6470052
SGTC_541 4513-1321 94 µM -1.1722259645339 0.113788185979399 no 3001 0.120553173317335 943 747515
SGTC_2427 5545055 42.75 µM -1.1745975495511 0.113315661334912 no 3002 0.120077882067555 955 5372858
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.17622360568096 0.112992488907791 no 3003 0.119752766957121 980 75037 A free radical scavenger.
SGTC_474 dl-dihydrosphingosine 5 µM -1.17657131394733 0.112923468678143 no 3004 0.119683326490497 944 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1697 st025554 27.742 µM -1.17668386704506 0.112901133292077 no 3005 0.119660854710183 969 1269519
SGTC_656 4090-1979 187 µM -1.18212305432051 0.111825520159947 no 3006 0.118578438970705 957 22330961
SGTC_2975 9084847 53.72 µM -1.18326260318542 0.111601103123648 no 3007 0.118352544475405 974 27211724
SGTC_1607 st000305 50.6 µM -1.18413620695354 0.111429278318563 no 3008 0.11817957480612 977 5457690
SGTC_857 0438-0306 1.35 µM -1.18468694646102 0.111321053440642 no 3009 0.118070622741155 946 4686136
SGTC_1337 1486-1011 40.3 µM -1.18473009118986 0.111312578323097 no 3010 0.118062090478536 960 X1337
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.18529407559949 0.111201834750498 no 3011 0.1179505975395 954 2724278 An inhibitor of dopamine biosynthesis.
SGTC_177 1327-0068 8.361 µM -1.18636674943636 0.110991423035725 no 3012 0.117738748418909 963 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_942 3253-1115 227 µM -1.18920437063173 0.110436181179916 no 3013 0.117179627529877 976 46497897
SGTC_1133 3473-0247 50 µM -1.19065866053538 0.110152391055575 no 3014 0.116893806450261 941 711311
SGTC_892 0929-0076 29 µM -1.19288967498493 0.109718048345326 no 3015 0.116456291712463 959 5751038
SGTC_3277 9138724 49.47 µM -1.19658891937405 0.10900057665419 no 3016 0.115733410742561 980 15943418
SGTC_302 1094-0063 18.9 µM -1.19811701050371 0.10870518840831 no 3017 0.115435733727857 975 5440289
SGTC_1217 1183-1422 255 µM -1.19882693367538 0.108568152459571 no 3018 0.115297623696343 958 2849664
SGTC_2280 7785178 200 µM -1.2038699771453 0.107598273138887 no 3019 0.114319918760699 964 2954328
SGTC_2717 st081029 62.2815 µM -1.20584607238726 0.107219937553375 no 3020 0.113938423591922 956 5292846
SGTC_932 2857-0803 154 µM -1.20652534969059 0.10709010752968 no 3021 0.113807495411138 971 674898
SGTC_2239 6685329 187.64 µM -1.20737104345448 0.106928628885511 no 3022 0.1136446409674 948 805680
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.20842009310153 0.106728565205433 no 3023 0.113442857420847 964 688788
SGTC_1514 1189-1591 158 µM -1.21038387278367 0.106354780288465 no 3024 0.113065813656146 986 767698 YMR146C TIF34
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.21185137305138 0.106076074783306 no 3025 0.112784639487509 939 6708630 An antioxidant.
SGTC_691 1548-0686 185 µM -1.21230797831212 0.105989464709795 no 3026 0.112697255491284 959 46495133
SGTC_1312 1218-2183 165 µM -1.21306553430121 0.105845882259455 no 3027 0.112552382948405 976 6744073
SGTC_1260 0700-1617 7.75 µM -1.21436670901733 0.105599593908119 no 3028 0.112303861077988 954 2853078
SGTC_2296 7971656 126.45 µM -1.21549384352583 0.105386583339052 no 3029 0.112088897725137 968 666570
SGTC_742 0kpi-0133 140 µM -1.21550532663855 0.105384414813208 no 3030 0.112086709218647 981 2728852
SGTC_675 1309-0189 238 µM -1.215577086762 0.105370864019925 no 3031 0.112073033523336 970 4246530
SGTC_117 lucigenin 22.078 µM -1.21581033583151 0.105326827235185 no 3032 0.112028590290043 1006 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_885 0865-0106 16.8 µM -1.22144153241462 0.104267710683378 no 3033 0.110959445058128 972 2793380
SGTC_369 0957-0393 4.5 µM -1.22244674056725 0.104079465731114 no 3034 0.110769366458798 987 6997992
SGTC_2834 9001755 58.44 µM -1.22595693398298 0.103424045911594 no 3035 0.110107440918478 975 2989575
SGTC_493 zm226600 134 µM -1.22745420878452 0.103145389635382 no 3036 0.10982596126381 981 5240098 A potassium channel opener. YCR052W RSC6
SGTC_783 0848-0141 92.7 µM -1.22970406016622 0.102727697929818 no 3037 0.109403972929501 974 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_507 nimesulide 162 µM -1.23071671160053 0.102540097824377 no 3038 0.109214417773186 985 4495 A COX2 inhibitor.
SGTC_1951 sophoraflavanone G 9.2 µM -1.23502847271742 0.101744104540723 no 3039 0.108409953813696 967 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_784 4579-0127 173 µM -1.23701223951728 0.101379396509411 no 3040 0.108041269362088 984 1948547
SGTC_2687 chenodiol 100 µM -1.23723508193587 0.101338487347181 no 3041 0.107999910410951 962 5702181 A cholesterol synthesis inhibitor.
SGTC_2060 5238662 140 µM -1.23971385497873 0.100884247649768 no 3042 0.107540625345505 996 790130
SGTC_3344 9148862 3.898 µM -1.24047605465342 0.100744872034382 no 3043 0.107399682805028 1003 4905352
SGTC_688 0527-0193 473 µM -1.2419789554046 0.1004704635647 no 3044 0.107122163357526 1008 4007154
SGTC_3235 9132602 49.47 µM -1.247462075586 0.0994739477163439 no 3045 0.106114058802816 980 4912240
SGTC_378 3970-0959 8.33 µM -1.24926798013883 0.0991473249120281 no 3046 0.105783537602369 1003 6615653
SGTC_2994 9053520 71.4286 µM -1.25000727198462 0.0990138402656414 no 3047 0.105648445451553 982 4647384
SGTC_137 0438-0332 85.389 µM -1.25683840997838 0.0977866423382861 no 3048 0.104406077192228 987 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1068 loratadine 26.9 µM -1.25743490561793 0.0976800149695199 no 3049 0.104298098153908 1006 3957 A H1 histamine antagonist.
SGTC_111 0083-0039 52.457 µM -1.25870847191007 0.0974526422949296 no 3050 0.104067825129565 962 759313
SGTC_2524 avocatin b 10.57 µM -1.26031508907322 0.0971663633697576 no 3051 0.103777859419786 979 6710748
SGTC_442 cape 100 µM -1.26506981463748 0.0963227478678186 no 3052 0.102923151179873 998 5281787
SGTC_1081 sertraline 6 µM -1.26629749903793 0.0961058007983831 no 3053 0.102703296008465 978 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_44 0929-0055 61.211 µM -1.268208588541 0.095768802780186 no 3054 0.10236173537988 954 1379590
SGTC_1793 st048256 72.231 µM -1.2708595761862 0.0953027729268938 no 3055 0.101889304807852 976 672022
SGTC_2350 9023895 38.85 µM -1.27136136226519 0.095214749787905 no 3056 0.101800060784591 955 2997209
SGTC_521 r062-0005 13.8 µM -1.27165540475621 0.0951631967834896 no 3057 0.101747790974028 992 2832033
SGTC_418 lividomycin a 100 µM -1.27175250171225 0.0951461777735461 no 3058 0.101730535041123 982 72394 An antibiotic.
SGTC_3226 9131256 49.47 µM -1.27298667216749 0.0949300494976696 no 3059 0.101511385649584 947 17178073
SGTC_1921 5740136 50 µM -1.27469876646038 0.0946308262728381 no 3060 0.101207941813624 970 1774243
SGTC_3045 9092950 49.47 µM -1.27551503409874 0.0944884119218143 no 3061 0.101063503146283 992 44120432
SGTC_502 l-744,832 89.3 µM -1.27574291114293 0.0944486824052749 no 3062 0.101023207113022 990 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1843 st055809 45.5 µM -1.27910311007728 0.0938642734239597 no 3063 0.100430374286471 994 16413835
SGTC_2682 pyrogallin 40.03 µM -1.28025040620638 0.0936653470725538 no 3064 0.100228541722999 988 822798 An ATP competetive kinase inhibitor.
SGTC_1222 0366-0074 1.18 µM -1.28259734109401 0.0932593888024229 no 3065 0.0998165911001044 996 286520
SGTC_2932 9016711 44.54 µM -1.2827419764474 0.0932344132680562 no 3066 0.099791244198157 1002 7117328
SGTC_3251 9135047 49.47 µM -1.28514053810269 0.0928209515789651 no 3067 0.0993715889348595 995 17682963
SGTC_2107 5363541 170.161 µM -1.28596148075483 0.0926797501854895 no 3068 0.0992282525740128 981 244052
SGTC_1759 st043059 70 µM -1.289770165071 0.092026737810207 no 3069 0.0985652348249947 989 669426
SGTC_78 0336-0123 156.75 µM -1.29419780408375 0.0912718931577987 no 3070 0.0977985525498156 980 6765896
SGTC_975 1335-0046 28.5 µM -1.29513265531331 0.0911131039575726 no 3071 0.097637235792834 993 16486740
SGTC_845 0330-0138 4.51 µM -1.2953197358689 0.0910813519979413 no 3072 0.0976049768493691 990 9039800
SGTC_1424 4048-1941 275 µM -1.30169237343424 0.0900046612679808 no 3073 0.0965107838713519 987 X1424
SGTC_133 0724-0033 378.92 µM -1.30254908990327 0.0898606387086519 no 3074 0.096364374104799 983 280309
SGTC_2639 lactacystin 53 µM -1.30413834911726 0.089593922147926 no 3075 0.0960932077743138 962 3870 A proteasome inhibitor.
SGTC_1446 4239-0190 62 µM -1.31062490063583 0.0885114230994819 no 3076 0.0949922611358993 1012 1340085
SGTC_316 k060-0003 58.6 µM -1.31128905043731 0.0884011396743949 no 3077 0.0948800631420477 1006 6152314
SGTC_3025 9087895 49.47 µM -1.31304328096101 0.0881103385605107 no 3078 0.0945841822067283 997 17173641
SGTC_1294 1000-1494 117 µM -1.31348698274371 0.0880368986592112 no 3079 0.0945094522158676 993 712797 YDL207W GLE1
SGTC_1361 1608-0041 5.61 µM -1.31405120487943 0.0879435766005183 no 3080 0.0944144865995953 979 X1361
SGTC_1500 4488-1866 171 µM -1.31768643751115 0.0873440790773515 no 3081 0.0938043182647097 1001 2900003
SGTC_2065 5221596 34.26 µM -1.31913831925692 0.0871054991569903 no 3082 0.0935614372476602 980 788581
SGTC_3257 9139206 32.98 µM -1.32075563476867 0.0868403078006191 no 3083 0.0932914284617575 996 4910041
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.32450886186086 0.0862272158630139 no 3084 0.0926670509443362 1009 6708784 An antioxidant flavonoid
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.32560696954491 0.0860484529222485 no 3085 0.0924849582339776 956 88881 An O-methylated flavonoid and antioxidant.
SGTC_3111 9122088 49.47 µM -1.32682214811018 0.0858509551621292 no 3086 0.0922837610790245 975 16876704
SGTC_1483 3453-0561 55.9 µM -1.32686720800646 0.085843638299323 no 3087 0.0922763067443387 996 4546991
SGTC_3346 9158254 43.5805 µM -1.32772153586097 0.0857050001445719 no 3088 0.0921350581611056 991 17639500
SGTC_792 4534-1957 155 µM -1.3308130365356 0.0852047198845117 no 3089 0.0916252686483916 1000 1717904
SGTC_3269 9137823 49.47 µM -1.33092093960502 0.0851872981373112 no 3090 0.0916075132196121 965 17682936
SGTC_724 3910-0327 137 µM -1.33161759065868 0.0850748829235631 no 3091 0.0914929407896267 1004 2885483
SGTC_1115 galangin 695.678 nM -1.33273082903112 0.0848954758644335 no 3092 0.0913100761978039 1014 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_714 4296-0578 26.1 µM -1.3333509216569 0.0847956661689778 no 3093 0.0912083350974301 988 1589775
SGTC_979 1426-2828 121 µM -1.33515202692713 0.0845062604171988 no 3094 0.0909132971839407 1019 747872
SGTC_2001 4023502 57.655 µM -1.33596217057437 0.0843763265381088 no 3095 0.0907808191724772 980 108941 YCR052W RSC6
SGTC_53 0973-0023 39.979 µM -1.33625705294084 0.0843290694291041 no 3096 0.090732634376199 986 674768
SGTC_3323 9138564 53.9225 µM -1.33826823186674 0.0840072924890857 no 3097 0.0904045068698632 992 43912313 YNL103W MET4
SGTC_248 streptozotocin 5.23457 mM -1.33865600502071 0.0839453571892237 no 3098 0.090341342424819 993 5300 DNA alkylating agent.
SGTC_1456 k015-0012 13 µM -1.34168740998541 0.0834623611421444 no 3099 0.0898486854479636 999 2989616
SGTC_3073 9114972 49.47 µM -1.34224016527824 0.0833745158144531 no 3100 0.0897590685882729 991 41905075
SGTC_2907 7721985 69.9 µM -1.34250923839789 0.083331779163095 no 3101 0.0897154684765806 1003 3267881
SGTC_415 dibenzyl ketone 100 µM -1.34818954140516 0.0824334205553276 no 3102 0.0887987137874349 1001 7593
SGTC_2945 9067681 61.76 µM -1.34913408124791 0.082284748189817 no 3103 0.0886469515564019 1015 16456930
SGTC_2480 5767542 37.17 µM -1.34930772507518 0.0822574383093496 no 3104 0.0886190726829884 989 2867358
SGTC_3168 9103419 49.47 µM -1.35184154724095 0.0818597069477236 no 3105 0.0882130049634899 1011 16649256
SGTC_3086 9117350 49.47 µM -1.35234127244785 0.0817814370110966 no 3106 0.0881330835159721 979 2679265
SGTC_1682 st012968 530 nM -1.35772676633193 0.0809415053580314 no 3107 0.0872752001265077 978 24207270
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.36408739615382 0.0799578960457738 no 3108 0.0862700305478 1032 390807
SGTC_1153 4055-0057 267 µM -1.36472434792632 0.0798598976968455 no 3109 0.086169852034064 991 882706
SGTC_1360 1598-0022 39.8 µM -1.36494425379336 0.0798260851359085 no 3110 0.0861352858898607 1008 761525
SGTC_3084 9116877 49.47 µM -1.36531024666215 0.0797698343553085 no 3111 0.0860777798998772 995 27241325
SGTC_617 3770-0098 35 µM -1.36866172433842 0.0792561270965877 no 3112 0.0855525200165256 993 5962639
SGTC_701 4424-0219 185 µM -1.37231245307296 0.0786994055270192 no 3113 0.0849830952872608 1009 2911779
SGTC_3034 9090421 49.47 µM -1.38073076810959 0.0774269477566662 no 3114 0.0836808786335902 988 17173761
SGTC_1935 st074532 41.6 µM -1.38122911590571 0.0773521135072686 no 3115 0.0836042625598157 984 2829742
SGTC_189 3970-0742 2.116 µM -1.38493716269737 0.076797020002252 no 3116 0.0830358411567718 1000 2891807
SGTC_1977 st070720 65.3 µM -1.38505086911346 0.0767800461724002 no 3117 0.0830184566901543 998 682188
SGTC_657 3534-0529 86.7 µM -1.38813588016037 0.0763206107015882 no 3118 0.08254783632202 1040 1049549
SGTC_645 0845-0943 5.41 µM -1.39033415682135 0.0759945107624912 no 3119 0.0822137151618477 1004 1885106
SGTC_2396 5342950 42.78 µM -1.39709864898518 0.0749976966963391 no 3120 0.0811919540196395 973 1886677
SGTC_199 4063-0024 41.6 µM -1.39758621622487 0.0749262360247604 no 3121 0.0811186799530726 1025 306215
SGTC_62 0180-0423 3.232 µM -1.39771165168575 0.0749078598816377 no 3122 0.081099836951672 1002 30102 YGL099W LSG1
SGTC_543 3844-1095 191 µM -1.39846714236694 0.0747972541148546 no 3123 0.0809864164738453 1000 4230703
SGTC_2851 9015922 71.43 µM -1.40262072943133 0.0741913829080405 no 3124 0.0803649834793737 994 2996893
SGTC_2155 5570423 76 µM -1.40633324263858 0.0736530287109195 no 3125 0.0798125966582419 1016 797402
SGTC_1941 st076221 61.8 µM -1.40799384931223 0.0734131918138638 no 3126 0.0795664456413251 970 2828568
SGTC_1235 benzylparaben 21.5 µM -1.40848390468081 0.0733425287190262 no 3127 0.0794939148274082 1026 7180
SGTC_2419 paclitaxel 166.5 µM -1.41331403615525 0.0726488331660412 no 3128 0.0787817043770554 1003 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1709 st033179 39.1045 µM -1.41365170442133 0.0726005263641722 no 3129 0.0787320960595427 1007 573381
SGTC_673 1082-0474 110 µM -1.41543947511101 0.0723451778349269 no 3130 0.0784698412241478 997 3098046
SGTC_737 1950-0117 57.9 µM -1.41574763527109 0.0723012327236265 no 3131 0.0784247030391589 1009 5393513
SGTC_452 diindolylmethane 8 µM -1.42028049290559 0.0716571866412152 no 3132 0.077763018951452 1012 3071 Inhibits expression of several cancer promoting factors.
SGTC_1797 st048695 56.8 µM -1.42502271240817 0.070988114042172 no 3133 0.0770753179245521 993 592262 YIL048W NEO1
SGTC_1093 fluphenazine 7.97 µM -1.42701167360365 0.0707089269502816 no 3134 0.0767882649184721 1027 6602611 An atypical antipsychotic.
SGTC_2976 9009005 19.48 µM -1.42903617533301 0.0704256183812422 no 3135 0.0764969181011785 993 2993148
SGTC_3119 9125183 49.47 µM -1.42906865450106 0.0704210803730091 no 3136 0.0764922508748317 997 22695334
SGTC_2150 5556613 200 µM -1.43472823410068 0.0696337481366266 no 3137 0.0756822776560047 1020 743190
SGTC_2438 5259590 200 µM -1.43768745386263 0.0692247835301066 no 3138 0.0752613772301186 1018 1201127
SGTC_1404 3909-7820 48.3 µM -1.43785163401116 0.0692021481070167 no 3139 0.0752380776549128 968 23741373
SGTC_2657 nystatin 74.44 µM -1.43818490712932 0.069156217470487 no 3140 0.075190798214995 999 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3124 9127567 49.47 µM -1.44347705087369 0.0684300152430881 no 3141 0.0744430663422298 996 17592030
SGTC_1194 1488-0194 225 µM -1.44369597993875 0.0684001004225527 no 3142 0.0744122563756231 1018 1391452
SGTC_84 0443-0269 128.823 µM -1.44913217923434 0.0676605208567979 no 3143 0.0736503364973612 991 6150058
SGTC_158 k038-0087 26.446 µM -1.45062318057448 0.0674587578111374 no 3144 0.0734424084405559 985 X158
SGTC_1340 1486-1359 257 µM -1.45444344755493 0.0669439193852044 no 3145 0.0729117008371842 994 4309068
SGTC_1750 st081859 2.357 µM -1.45844899968731 0.0664073805509205 no 3146 0.0723584114736786 987 5291695
SGTC_2021 4019055 173 µM -1.46158018874587 0.0659902850407389 no 3147 0.0719281432786062 1009 44827708 YER133W GLC7
SGTC_3271 9137798 49.47 µM -1.46528036994281 0.0655000158744234 no 3148 0.0714222199686796 965 6498326
SGTC_3164 9100705 49.47 µM -1.46684578105555 0.0652934532101874 no 3149 0.071209006284743 1000 17174235
SGTC_2748 diazoxide 86.69 µM -1.4684779570878 0.0650786191581151 no 3150 0.0709872197627603 993 3019 A potassium channel activatior.
SGTC_1590 st077108 57.8 µM -1.47291522488488 0.0644973395524549 no 3151 0.0703869481177211 1011 5489485
SGTC_291 SEC14.278 35.5 µM -1.47364233814615 0.0644024739464635 no 3152 0.0702889578106229 1016 1068044
SGTC_846 0335-0850 148 µM -1.47465001392008 0.0642711829664729 no 3153 0.0701533306321949 1013 6819598
SGTC_2954 9074818 52.69 µM -1.4749426201796 0.0642330980319519 no 3154 0.0701139853032016 1021 16648742
SGTC_81 0411-0046 9.971 µM -1.47585992955589 0.0641138169098752 no 3155 0.0699907492261807 1000 12925265
SGTC_1052 3253-3998 198 µM -1.47817468073812 0.0638135867915101 no 3156 0.06968051451284 1015 5450317
SGTC_22 0964-0034 14.468 µM -1.47935486477141 0.0636609348993652 no 3157 0.0695227482521747 1030 138402
SGTC_3150 9097574 49.47 µM -1.48143910666845 0.0633920409938167 no 3158 0.0692448001163834 1011 17217476
SGTC_1606 st000094 49.2 µM -1.48583193111836 0.0628282063325045 no 3159 0.0686617909331136 1008 1242210
SGTC_1038 k292-0204 154 µM -1.49113584286512 0.062152646469067 no 3160 0.0679629168108306 1017 4454212
SGTC_1028 k015-0029 4.8 µM -1.49281375936432 0.0619401140688136 no 3161 0.0677429722912708 1029 4588309
SGTC_2309 7664088 163.95 µM -1.49328500578505 0.0618805260203501 no 3162 0.067681299404849 996 704922
SGTC_2941 9056145 11.23 µM -1.4964701140558 0.0614789486943513 no 3163 0.0672655951462957 1008 2119517
SGTC_2417 cerulenin 830 nM -1.51311803810023 0.0594130165264954 no 3164 0.0651248392508616 1021 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2950 9072895 21.46 µM -1.51397722580033 0.0593078903512051 no 3165 0.0650158078744783 1000 17332245
SGTC_2376 9072922 81.32 µM -1.51755018070826 0.0588722839570394 no 3166 0.064563917058698 1023 17087968
SGTC_3064 1327-0027 10 µM -1.51955969297878 0.0586283942487212 no 3167 0.06431083735878 1004 16000455 YPR107C YTH1
SGTC_1396 3511-0007 98.6 µM -1.52256711062942 0.0582648737746798 no 3168 0.0639335217137626 1012 X1396
SGTC_306 1672-3436 11.6 µM -1.52259458656191 0.0582615608124601 no 3169 0.0639300824903778 1032 6797378
SGTC_2162 5663267 200 µM -1.52540035572458 0.0579240283457012 no 3170 0.0635796350474958 1021 6456493
SGTC_222 nsc-310342 10.666 µM -1.5255515345035 0.057905885354633 no 3171 0.0635607949745437 1032 432556
SGTC_29 0299-0004 12.984 µM -1.52896356287432 0.0574975941683945 no 3172 0.0631367385484672 1020 16871 A napthoquinone isolated from Swertia calycina.
SGTC_997 3996-0078 137 µM -1.53024077541376 0.057345343753136 no 3173 0.0629785709155169 1013 735687
SGTC_1495 4469-0029 237 µM -1.53426355478981 0.0568678797265201 no 3174 0.0624824139414394 1019 793680
SGTC_989 1501-0895 10.3 µM -1.53500038537589 0.0567807654437021 no 3175 0.0623918666880094 1017 2830112
SGTC_3157 9099274 49.47 µM -1.53512884809408 0.0567655882710076 no 3176 0.0623760907083208 1012 17217662
SGTC_1561 5-methoxyflavone 52.9 µM -1.53767878276923 0.0564649880568595 no 3177 0.0620635869444174 1007 94525
SGTC_1860 st056228 74.6 µM -1.5429466069473 0.0558479618740483 no 3178 0.0614218656159221 1034 688679
SGTC_2525 harmine 47.85 µM -1.54807604077316 0.0552522694699239 no 3179 0.0608019949023689 1011 5280953 A monoamine oxidase inhibitor
SGTC_2254 7938975 95.19 µM -1.5482804701075 0.05522863303544 no 3180 0.0607773922101593 1025 2969277
SGTC_2233 sulbentine 40.3845 µM -1.55039231374247 0.054984925570198 no 3181 0.0605236911348814 996 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.55160480403526 0.0548453882615398 no 3182 0.0603784064872944 1019 756377
SGTC_2744 captopril 92.04 µM -1.55636424144888 0.0543003606185034 no 3183 0.0598107516214012 1039 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_179 1273-0063 6.77 µM -1.56587630597081 0.0532239314884866 no 3184 0.0586887889098256 1043 3108139
SGTC_2499 avocadenofuran 51.48 µM -1.56621917104787 0.0531854494545788 no 3185 0.0586486580454801 1023 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1882 5615643 20 µM -1.56794357844337 0.052992242050035 no 3186 0.0584471501908891 981 2253075
SGTC_661 1304-0007 33.6 µM -1.57666076791984 0.0520240488681615 no 3187 0.0574368010610774 1043 3117130
SGTC_2876 9059903 25.97 µM -1.58218574356463 0.0514177176050632 no 3188 0.0568035869737874 1030 6916095
SGTC_1120 ficusin 1.78878 µM -1.58266619266543 0.0513652580791832 no 3189 0.0567487838715713 1037 6199 A DNA cross-linker.
SGTC_2804 7954240 19.48 µM -1.58401454263481 0.0512182611143515 no 3190 0.0565952048704357 1026 828705
SGTC_1764 st044502 93.5 µM -1.58595456096753 0.0510073479888246 no 3191 0.0563748087684393 1027 8407
SGTC_2798 7813637 45.45 µM -1.58712279844176 0.0508806744771399 no 3192 0.0562424176550724 1027 956368
SGTC_2991 9074669 71.4286 µM -1.58822201884606 0.0507617133920882 no 3193 0.0561180718805774 1016 17333109
SGTC_1180 1193-0155 285 µM -1.58865658938932 0.0507147439354072 no 3194 0.0560689723215375 1045 2921347
SGTC_1448 4255-0083 152 µM -1.5914226726438 0.0504165895830995 no 3195 0.0557572425951226 1048 5399660
SGTC_3132 9126706 49.47 µM -1.59153901307277 0.0504040799956468 no 3196 0.055744161390259 1025 850858
SGTC_1333 1482-0047 286 µM -1.59225979003869 0.0503266330583364 no 3197 0.0556631718999338 1031 3811116
SGTC_2946 9065502 71.43 µM -1.59662062222448 0.0498600855530394 no 3198 0.0551751496056667 979 16489101
SGTC_279 1273-0055 2.93 µM -1.59715942022008 0.0498026820002177 no 3199 0.0551150878472368 1041 2847562
SGTC_624 k048-0052 28 µM -1.60118533735505 0.049375427639554 no 3200 0.0546679377199284 1041 6835531
SGTC_1510 1123-0200 71.5 µM -1.60560855628575 0.0489093882606214 no 3201 0.0541799721559603 1038 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3200 9114385 49.47 µM -1.61145077008339 0.048299235135138 no 3202 0.0535407545329342 1016 17018030 YLR208W SEC13
SGTC_135 0933-0004 26.348 µM -1.62282019233285 0.0471292907882335 no 3203 0.0523139239568993 1019 21230617 YGL099W LSG1
SGTC_871 0574-0004 149 µM -1.62310009255397 0.0471007774115089 no 3204 0.0522840049234927 1047 9551173
SGTC_2147 5545932 89.7195 µM -1.62491225252237 0.0469165075355917 no 3205 0.0520906285460361 1054 797404
SGTC_1366 1683-0113 21.9 µM -1.62826441543896 0.0465771663815391 no 3206 0.0517344156778603 1047 708623
SGTC_2737 bleomycin 30.5 nM -1.63078340889146 0.0463234658401749 no 3207 0.0514680147314116 1029 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.63412951149906 0.0459881800298718 no 3208 0.0511158296830223 1037 16725076
SGTC_1032 k061-1018 98.7 µM -1.64176802324805 0.045230090665812 no 3209 0.0503190441564113 1045 4005393
SGTC_1492 4158-0558 28.5 µM -1.64304157659424 0.0451046794196489 no 3210 0.0501871656620929 1009 3967268
SGTC_2820 7989630 71.43 µM -1.64652856865758 0.0447627346871826 no 3211 0.0498274916375761 1024 2984098
SGTC_2537 larixol 68.93 µM -1.64902756243102 0.0445189624432502 no 3212 0.0495709940971299 1032 6708759
SGTC_2739 tacrine 100.86 µM -1.65426467205512 0.0440115613193212 no 3213 0.0490368738369919 957 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1491 4138-0063 26.5 µM -1.65486685250381 0.0439535187700919 no 3214 0.048975754719168 1047 23883227
SGTC_2871 9038510 12.99 µM -1.65490133496093 0.0439501969686767 no 3215 0.0489722567187698 1040 4945164
SGTC_8 0354-0001 70 µM -1.66273957895854 0.043200352727982 no 3216 0.0481822879550421 1051 4993152
SGTC_165 k038-0023 64.381 µM -1.664491304871 0.0430341947917887 no 3217 0.0480071436314811 1043 46368543
SGTC_1908 st060353 56.5 µM -1.66817348090825 0.0426866095256681 no 3218 0.0476406468206601 1031 4227716
SGTC_4 0960-0234 25.671 µM -1.668196909818 0.0426844052021497 no 3219 0.0476383220735513 1021 6821112
SGTC_628 1636-0253 16 µM -1.67119723243945 0.0424028775777656 no 3220 0.0473413633696353 1025 4456143
SGTC_2302 7771753 200 µM -1.67855797538062 0.0417185603812975 no 3221 0.0466191113051336 1018 2203047
SGTC_2271 7849410 118.62 µM -1.68384218002532 0.0412328330022856 no 3222 0.0461060865317804 1050 972430
SGTC_86 0417-1630 471.922 µM -1.68985130443218 0.0406860525414145 no 3223 0.0455282028504501 1033 3634867
SGTC_245 methotrexate 289.6 µM -1.69210045299395 0.0404829181804235 no 3224 0.0453134110574835 1033 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2693 st077581 40.7 µM -1.69292272759705 0.0404088593851873 no 3225 0.0452350883016865 1005 25238761
SGTC_3021 9087658 49.47 µM -1.69693307616522 0.040049239394565 no 3226 0.0448546569036671 1039 25237042
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.7046371768835 0.0393656872418099 no 3227 0.0441310566160277 1052 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_98 0074-0023 107.663 µM -1.70549106926216 0.0392905128720362 no 3228 0.0440514382449712 1050 3563821
SGTC_1276 0871-0068 94.2 µM -1.70623657786569 0.0392249758730756 no 3229 0.0439820205022601 1046 3414906
SGTC_2919 7978188 46.38 µM -1.70989795926517 0.0389043973860009 no 3230 0.0436423719450965 1040 2980291
SGTC_3165 9101544 49.47 µM -1.71156585387105 0.0387590710577432 no 3231 0.043488352747089 1052 5002184
SGTC_3345 9148410 3.559 µM -1.72221144470198 0.0378418910013883 no 3232 0.0425156111964838 1016 4903596
SGTC_2747 doxorubicin 7.63 µM -1.73348002090394 0.0368904135852064 no 3233 0.0415051927807142 1018 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2534 helenine 20.12 µM -1.74219103753989 0.0361683684452679 no 3234 0.0407375108658717 1030 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1198 1612-1005 86.7 µM -1.74299310157172 0.0361024721953584 no 3235 0.0406674099116802 1040 6998509
SGTC_2497 7-hydroxyflavone 100 µM -1.74473306666236 0.0359598575105749 no 3236 0.0405156722946713 1042 5281894
SGTC_2180 6301957 200 µM -1.7496247065155 0.0355613893802011 no 3237 0.0400915468137781 1038 845462
SGTC_3155 9099265 49.47 µM -1.75522215345269 0.035109875233327 no 3238 0.0396106579936868 1043 25236499
SGTC_1403 3909-7815 62.9 µM -1.75547102535769 0.0350899098809291 no 3239 0.0395893862634115 1050 6615483
SGTC_3339 9145883 14.936 µM -1.7666392684525 0.034203500426951 no 3240 0.0386443300942464 1011 2030670
SGTC_983 1491-0821 12.2 µM -1.77037153129777 0.033911410957084 no 3241 0.0383326345110557 1049 46495113
SGTC_130 0136-0219 337.655 µM -1.77522949101796 0.033534300064512 no 3242 0.0379300010726979 1044 234244
SGTC_2359 9039622 200 µM -1.79011167001552 0.0324004677681541 no 3243 0.0367179805477679 1065 6463596
SGTC_27 0485-0001 32.618 µM -1.79147531013969 0.0322981768436987 no 3244 0.0366085265947149 1035 2054479
SGTC_2213 7173844 200 µM -1.79262836607056 0.0322118905891808 no 3245 0.0365161837963011 1054 892728
SGTC_2648 atorvastatin 78.68 µM -1.79591261486139 0.0319671637634568 no 3246 0.0362542079279581 1052 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_417 st075190 100 µM -1.79712324197052 0.0318773416990524 no 3247 0.0361580283502109 1054 222757
SGTC_3136 9095672 49.47 µM -1.80227764219563 0.0314972429574444 no 3248 0.0357508671622967 1042 17217380
SGTC_1262 0737-0114 49.6 µM -1.80655840047779 0.0311844236752438 no 3249 0.0354155803126545 1055 765919
SGTC_151 3013-0144 2.285 µM -1.81753079743375 0.0303943281965601 no 3250 0.0345679385153178 1033 906558 YHR107C CDC12
SGTC_534 k292-0788 63.4 µM -1.81874958036843 0.0303075992268243 no 3251 0.0344748218864302 1060 4146317
SGTC_2024 5144227 134 µM -1.82840904049386 0.0296274580568518 no 3252 0.0337440927923894 1050 3475211
SGTC_3342 9147791 14.508 µM -1.83141223545686 0.0294185966700756 no 3253 0.0335195182102328 1054 1838168
SGTC_2791 5663188 71.43 µM -1.83691401393471 0.0290391390870984 no 3254 0.0331112950676071 1042 54690634
SGTC_928 2764-0428 58.7 µM -1.83801714356909 0.0289635478248595 no 3255 0.0330299395829421 1056 662578
SGTC_1815 st051655 58.2 µM -1.84884638893747 0.0282301271251053 no 3256 0.0322399983889136 1045 5984156
SGTC_852 0418-0143 439 µM -1.84906907106901 0.0282152095020789 no 3257 0.0322239198649921 1002 5369229
SGTC_1435 4092-0789 56.7 µM -1.85363578318975 0.0279107267330152 no 3258 0.0318956423122304 1055 2248285
SGTC_3162 9099653 49.47 µM -1.86730498644925 0.0270156562704057 no 3259 0.0309295047320666 1058 25237511
SGTC_1659 st012954 42.1 µM -1.87841847313509 0.0263057094280238 no 3260 0.0301619701715289 1057 24207262
SGTC_1875 nocodazole 6 µM -1.88175202151775 0.0260958226219707 no 3261 0.0299348464340845 1060 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2644 guaiazulene 100 µM -1.8884285204369 0.0256796670654082 no 3262 0.0294842227625741 1051 3515 A coloring agent.
SGTC_2606 farnesol 9.78 µM -1.88972870193615 0.0255992746079251 no 3263 0.0293971266895847 1039 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2782 7736369 71.43 µM -1.89300530605255 0.0253976107351699 no 3264 0.0291785819213497 1043 2950836 YOL077C BRX1
SGTC_2886 9058944 51.95 µM -1.90161634610181 0.0248739655515314 no 3265 0.0286106646839716 1063 4949929
SGTC_1272 0839-0021 27 µM -1.90566753039102 0.0246307588218457 no 3266 0.0283466772559192 1066 5027250
SGTC_3237 9133362 49.47 µM -1.91413703016952 0.0241287472040461 no 3267 0.0278013245521767 1065 43845137
SGTC_1200 1643-0193 18.4 µM -1.91414629737919 0.0241282026530419 no 3268 0.0278007326567833 1060 5403974
SGTC_1973 st070275 50.2 µM -1.91619434046682 0.024008110476758 no 3269 0.0276701817445625 1068 17118334
SGTC_1080 nisoldipine 24.4 µM -1.91918315087278 0.0238337556369432 no 3270 0.0274805795564494 1057 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2793 7325131 81.82 µM -1.93327441526512 0.023026004231264 no 3271 0.0266012009175549 1049 4176441
SGTC_1190 1486-1332 13 µM -1.93402713688584 0.0229835127482667 no 3272 0.0265548957143324 1056 4150046
SGTC_2400 5203494 178.7 µM -1.93816870100359 0.0227508992164287 no 3273 0.0263013219772206 1046 6777674
SGTC_698 k064-0052 127 µM -1.94008414138976 0.0226439901435024 no 3274 0.026184732491969 1083 5088751
SGTC_2017 5132927 60.65 µM -1.94174442665312 0.0225516653070574 no 3275 0.026084023774202 1057 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1802 st050112 57.9 µM -1.9676663249464 0.0211508752144773 no 3276 0.0245532214502147 1073 4662563
SGTC_52 0329-0193 875 nM -1.97039562112932 0.0210077649498005 no 3277 0.024396523523262 1053 3739292
SGTC_2463 5473429 200 µM -1.99378236395167 0.0198147448868213 no 3278 0.0230879218600663 1063 5399405
SGTC_80 0159-0065 512.242 µM -2.00595623459342 0.0192168177528881 no 3279 0.0224304588099967 1070 1548079
SGTC_368 fentichlor 4.58 µM -2.01894250568741 0.0185959644241431 no 3280 0.0217465978152396 1079 7329 A pesticide.
SGTC_2638 epoxomicin 18 µM -2.04291342140054 0.0174947488143168 no 3281 0.0205305047345816 1070 9915668 A protesome inhibitor.
SGTC_1905 st060207 84.5 µM -2.05147583351157 0.0171151266692727 no 3282 0.0201103153558685 1055 1948547
SGTC_2996 9066192 71.4286 µM -2.05429283040487 0.0169917815618569 no 3283 0.0199736791237471 1056 6472854
SGTC_1521 st012942 49.4 µM -2.06126996994019 0.0166895480328713 no 3284 0.0196386457382618 1068 24207259
SGTC_2402 5553605 200 µM -2.0619315137837 0.0166611316920224 no 3285 0.0196071283633927 1071 6758546
SGTC_835 0312-0010 67.2 µM -2.08730120374685 0.015602191074677 no 3286 0.0184304580247772 1074 1626196
SGTC_2624 nerol 100 µM -2.08783317767043 0.0155806191926598 no 3287 0.0184064428097042 1065 637566 A natural product oil.
SGTC_3219 9131112 49.47 µM -2.11012889015798 0.0146992435341246 no 3288 0.0174236277261239 1021 17612988 YMR079W SEC14
SGTC_806 3966-4455 5.86 µM -2.11058620940663 0.014681623538399 no 3289 0.0174039470209173 1070 714982
SGTC_1652 st011932 78 µM -2.11264637321246 0.0146024728769293 no 3290 0.0173155232200803 1060 1551076
SGTC_1903 st060211 78.3 µM -2.12408869686081 0.0141695144733222 no 3291 0.0168313637454674 1065 688960
SGTC_1707 st032323 6.317 µM -2.12945500007293 0.0139703020440779 no 3292 0.0166083170866339 1046 3132057 YMR211W DML1
SGTC_3007 9078383 71.4286 µM -2.14177250064013 0.0135221524665989 no 3293 0.0161058966601122 1078 6496995
SGTC_1721 st082152 9.2685 µM -2.1523787179963 0.013146262197971 no 3294 0.0156837692441221 1064 5296051
SGTC_1916 st067606 49.2 µM -2.15441428081302 0.013075162865413 no 3295 0.0156038488168191 1051 19590279
SGTC_283 0987-0079 11.7 µM -2.1592023056998 0.0129092330252064 no 3296 0.0154172376346417 1077 411556
SGTC_553 k007-0256 45.7 µM -2.15950532762991 0.0128987932913128 no 3297 0.015405492228382 1078 6287000
SGTC_2153 5569715 200 µM -2.1921603270326 0.0118157110115602 no 3298 0.0141839659957377 1082 2054701
SGTC_160 3453-0671 289.699 µM -2.20403802926767 0.0114418087140876 no 3299 0.0137608348571498 1076 5322268
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -2.20697849501586 0.0113508477035212 no 3300 0.0136577808927438 1080 165521
SGTC_1109 tnp00067 928.257 nM -2.20853682377711 0.0113028972594389 no 3301 0.0136034368968361 1074 676295
SGTC_50 0929-0078 56.389 µM -2.21851950331677 0.0109998820238813 no 3302 0.0132597156437835 1053 1377751
SGTC_2044 5102272 200 µM -2.22234605726931 0.0108856180483722 no 3303 0.0131299639047828 1081 592666
SGTC_2002 4023503 131 µM -2.22394828787578 0.0108380818183157 no 3304 0.0130759618401698 1068 4736863 YCR052W RSC6
SGTC_20 0481-0013 4.944 µM -2.23777646777031 0.0104352711096281 no 3305 0.0126178178669385 1075 182045
SGTC_150 3970-0969 77.2 µM -2.24352942317782 0.0102715713905932 no 3306 0.012431347341547 1068 6615640
SGTC_1779 st039427 55 µM -2.24678653606034 0.0101798870621197 no 3307 0.0123268363195689 1076 1124498
SGTC_756 0508-1999 28.3 µM -2.24933440145311 0.0101086657447928 no 3308 0.0122456143465375 1075 6753853
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.28333313188255 0.00919908813550709 no 3309 0.0112053764080493 1078 17037758
SGTC_3331 9141060 1.957 µM -2.29335821388535 0.00894493741979758 no 3310 0.0109136951336314 1076 4906567 YPR165W RHO1
SGTC_611 3453-1652 23.7 µM -2.31174483207229 0.00849476245671759 no 3311 0.0103958746070118 1083 1560575
SGTC_2730 imipramine 71.33 µM -2.31377410694158 0.00844631745492618 no 3312 0.0103400582014836 1075 3696 A tricyclic antidepressant.
SGTC_25 0118-0223 35.662 µM -2.31412426644662 0.00843798265237935 no 3313 0.0103304533354447 1079 5333628
SGTC_2274 7947094 46.08 µM -2.31637882517556 0.008384490351875 no 3314 0.0102687969329036 1079 2971028
SGTC_1596 piperlongumine 63 µM -2.32150669879648 0.00826393225672174 no 3315 0.0101297564896319 1070 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_352 k048-0007 5.11 µM -2.32245731559531 0.00824175098135058 no 3316 0.0101041621185646 1065 6811911
SGTC_859 0439-0102 54.6 µM -2.32411054019321 0.00820329990267694 no 3317 0.0100597851404385 1083 610143
SGTC_3139 9095020 49.47 µM -2.35652965394632 0.00748048903065699 no 3318 0.00922329738107257 1073 25236292
SGTC_1136 pergolide 1.05886 µM -2.3955724114621 0.00668492538281692 no 3319 0.00829721804916202 1078 47811 A dopamine receptor agonist.
SGTC_2641 levomentholum 100 µM -2.43235374294855 0.00600482688210946 no 3320 0.00750052428520283 1084 16666
SGTC_1828 st055811 49 µM -2.44330479907685 0.0058145524620134 no 3321 0.00727672008360127 1086 5877589
SGTC_3354 9151612 71.43 µM -2.44993847716887 0.00570191166613953 no 3322 0.00714403127745945 1079 27261949
SGTC_36 0335-0881 14.2 µM -2.4519958746018 0.00566737249698541 no 3323 0.00710331453452113 1062 23828853
SGTC_1286 0929-0070 131 µM -2.47053805169778 0.00536437553379746 no 3324 0.00674549826261113 1080 1420408
SGTC_2973 9094665 17.96 µM -2.47570391711977 0.00528256667574171 no 3325 0.0066486900940599 1074 25237061 YIL048W NEO1
SGTC_771 0250-0039 27.3 µM -2.58608369481576 0.00378023066660361 no 3326 0.00485366780364023 1086 3005115
SGTC_188 3229-0966 278.469 µM -2.61368240989209 0.00347030993496473 no 3327 0.00447861276268349 1080 5722370
SGTC_3215 9129942 49.47 µM -2.63491893303177 0.0032475825376385 no 3328 0.0042078690007419 1082 17682944
SGTC_176 1486-1328 72.834 µM -2.64832960212217 0.00311364146652927 no 3329 0.00404453082517264 1084 22310231
SGTC_1680 diphenhydramine 100 µM -2.66891588515862 0.00291769358273459 no 3330 0.00380482524262927 1073 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_924 2046-0044 21.3 µM -2.72357886539343 0.00245019096727585 no 3331 0.00322893975162772 1087 3623589
SGTC_2685 mycophenolic acid 18.85 µM -2.73754387497954 0.00234217193284584 no 3332 0.00309499312754796 1087 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_360 0957-0399 1.01 µM -2.74802926568484 0.00226392178726435 no 3333 0.00299773286851337 1085 6752301 YPR165W RHO1
SGTC_159 3970-0959 50 µM -2.75228963393643 0.00223280998453288 no 3334 0.0029590077359145 1083 6615653
SGTC_1971 st069429 63.5 µM -2.76551274113516 0.00213869833982179 no 3335 0.00284166924107787 1089 1246522 YGL099W LSG1
SGTC_877 0771-0151 33.1 µM -2.81791260062659 0.00180009775476408 no 3336 0.00241684826910186 1091 6166523
SGTC_1862 st057513 3.81 µM -2.83143263901564 0.00172103760243499 no 3337 0.00231699966271846 1089 5393163
SGTC_3336 9143619 71.43 µM -2.8387116984126 0.00167979376485808 no 3338 0.00226480309021496 1093 45595730
SGTC_3195 9113082 49.47 µM -2.86248035562254 0.00155130807991058 no 3339 0.00210169658238965 1086 17018038
SGTC_2806 7952793 58.44 µM -2.94744084600292 0.00116191097160183 no 3340 0.00160208024704059 1083 2972490
SGTC_1287 0971-0001 34.6 µM -2.95706237729301 0.00112398445938007 no 3341 0.00155292639839178 1089 4665869
SGTC_1126 isoteolin 1.0172 µM -3.02117905930519 0.000898857099791073 yes 3342 0.00125896205443427 1091 133323
SGTC_2478 5763493 32.33 µM -3.12144827303031 0.000628496886188427 yes 3343 0.000899819303157976 1084 1365576 YLR208W SEC13
SGTC_186 3455-3465 67.277 µM -3.20315296613902 0.000466061583303738 yes 3344 0.000679658794789993 1090 755278
SGTC_900 1112-0045 141 µM -3.20706870689525 0.000459352905780288 yes 3345 0.000670474825882859 1090 56211 YIL048W NEO1
SGTC_2415 st077333 57.7 µM -3.36852074547197 0.000249271219586686 yes 3346 0.000377863547548151 1082 2766255
SGTC_860 0443-0016 25.1 µM -3.47930940769819 0.000161392267092526 yes 3347 0.00025135390543756 1095 5337942
SGTC_3190 9110366 49.47 µM -3.49709773712821 0.000150337465749821 yes 3348 0.000235174737463868 1091 17123768
SGTC_3194 9111903 49.47 µM -3.59657333181577 0.000100500841503577 yes 3349 0.000161218357211424 1093 17087251
SGTC_2316 5844804 197.44 µM -3.84761317276647 3.47808125659953e-05 yes 3350 5.96370918186271e-05 1089 776813
SGTC_2608 thymoquinone 42.66 µM -4.14517222357842 9.09633392754469e-06 yes 3351 1.697792007732e-05 1093 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2272 7805186 180 µM -4.32511789471534 3.86773465831931e-06 yes 3352 7.62251538376608e-06 1093 2956062 YPR165W RHO1