SGTCid condition conc unit YDR269C|YDR269C.score YDR269C|YDR269C.strain.pval YDR269C|YDR269C.strain.significant YDR269C|YDR269C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_157 1348-1695 65.819 µM 21.723939959175 2.8116292067331e-109 yes 1 6.09330013480029e-105 4 5380510 SGTC_2675 theaflavin digallate 100 µM 10.4868449789362 4.40665279959793e-27 yes 2 4.9644295410576e-26 3 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2291 7917025 104.35 µM 8.50981387725933 1.71453999324824e-18 yes 3 8.71063876199445e-18 14 2964612 SGTC_2582 agaric acid 100 µM 8.10210055719219 6.14186918181358e-17 yes 4 2.70091321264988e-16 101 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2389 9091542 195.52 µM 7.44064132400745 1.41921714397409e-14 yes 5 5.00988295516642e-14 9 3626624 YOL127W RPL25 SGTC_263 alizarin 107.927 µM 7.39138450130992 2.09062320740313e-14 yes 6 7.26538764114529e-14 12 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2586 curcumin 80 µM 7.07819169723517 2.31570572198622e-13 yes 7 7.30238048640961e-13 6 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_374 0880-0231 82.3 µM 6.62090872944723 6.47655994755385e-12 yes 8 1.78498677607843e-11 3 6833587 SGTC_339 3091-4833 71.4 µM 5.84507642910003 1.13204502944662e-09 yes 9 2.53167868464584e-09 3 3240077 SGTC_2153 5569715 200 µM 5.34594576008103 2.27061400810251e-08 yes 10 4.49730713334783e-08 8 2054701 SGTC_2991 9074669 71.4286 µM 5.27588253512419 3.38979893009772e-08 yes 11 6.60593498770502e-08 26 17333109 SGTC_1230 0170-0365 3.77 µM 5.13737098145576 7.37706059439008e-08 yes 12 1.39304308524099e-07 36 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2275 7947463 200 µM 5.12946659620393 7.70728571291153e-08 yes 13 1.45282161638298e-07 20 1225414 SGTC_2021 4019055 173 µM 4.93568775907397 2.21093353197169e-07 yes 14 3.99344001408639e-07 69 44827708 YER133W GLC7 SGTC_3203 9113543 49.47 µM 4.86758808223204 3.17331420954386e-07 yes 15 5.64842430787362e-07 12 17018012 SGTC_431 k089-0097 107 µM 4.8435237154005 3.60151417198741e-07 yes 16 6.37782442217469e-07 16 5499420 SGTC_2046 4110841 106 µM 4.77033489871586 5.2737646355316e-07 yes 17 9.19599399534226e-07 13 44119630 YMR134W ERG29 SGTC_2335 9018011 154.17 µM 4.68085932671886 8.34522057827142e-07 yes 18 1.42837460721671e-06 19 6458208 SGTC_1658 st012944 20 µM 4.43342571753884 2.84745052364419e-06 yes 19 4.637373600624e-06 64 24207260 SGTC_1834 st055981 52.8 µM 4.43298661945255 2.85350344196981e-06 yes 20 4.6468317926661e-06 22 471719 YDL150W RPC53 SGTC_2867 9039098 71.43 µM 4.38850374127017 3.5348349044576e-06 yes 21 5.70665858567478e-06 24 6463460 SGTC_1411 3909-8223 150 µM 4.28760158383808 5.70318851207985e-06 yes 22 9.03063338097121e-06 7 X1411 SGTC_444 curcumin 90.4 µM 4.16866737190458 9.89287116420401e-06 yes 23 1.53192866864379e-05 22 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2597 laccaic acid a 100 µM 4.15971866630988 1.03055794210441e-05 yes 24 1.59319917546594e-05 31 5491415 A textile dye. SGTC_2354 9060492 162 µM 3.93693004240747 2.77856068305076e-05 yes 25 4.12653269456639e-05 17 6471895 SGTC_382 3229-0966 23.2 µM 3.92995654226751 2.86389310533489e-05 yes 26 4.24806078816085e-05 20 5722370 SGTC_3142 9086498 49.47 µM 3.88201273657275 3.52133662883073e-05 yes 27 5.17977250254499e-05 39 25236367 SGTC_1780 st038448 24.544 µM 3.8771308303055 3.59576174986715e-05 yes 28 5.28477646065327e-05 20 728868 YDL195W SEC31 SGTC_649 1123-0311 367 µM 3.86949660329353 3.71513597547052e-05 yes 29 5.45301503402084e-05 75 693629 YIL048W NEO1 SGTC_2896 9052656 71.43 µM 3.80959711571347 4.79062989821982e-05 yes 30 6.9596712256743e-05 126 6469436 SGTC_1040 k898-0338 155 µM 3.72574366584802 6.79790258611559e-05 yes 31 9.73701143440158e-05 26 20969351 SGTC_457 grayanotoxin iii 135 µM 3.65599455920872 9.04676116429038e-05 yes 32 0.000128093393860202 89 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1712 st032288 53.4 µM 3.63437217943652 9.87521073132979e-05 yes 33 0.00013932918219488 213 2883011 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 3.63212133960155 9.96543158556256e-05 yes 34 0.000140550440494087 52 676296 Flavone; oxidizing agent. SGTC_352 k048-0007 5.11 µM 3.61791404473381 0.000105530201188151 yes 35 0.000148493493981412 91 6811911 SGTC_699 0375-0592 111 µM 3.52482610665759 0.000152848039629143 yes 36 0.000211880434502447 33 762578 SGTC_1529 apigenin 74 µM 3.48482490247019 0.000178753821410611 yes 37 0.000246229592920575 50 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2418 pentamidine 31.67 µM 3.46101823825417 0.000196064224519911 yes 38 0.000269068176469456 66 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1450 4112-4260 37.6 µM 3.41492501532261 0.000234117443165119 yes 39 0.000318997862516718 46 1633175 SGTC_1207 2099-0101 141 µM 3.30630912575483 0.000352682008750312 yes 40 0.000472668663719783 44 5837381 SGTC_287 k060-0039 29.6 µM 3.2340506491112 0.000460244282333416 yes 41 0.000610239045857016 23 5861974 SGTC_2158 5657123 3.6195 µM 3.20899329406205 0.000504150002277059 yes 42 0.000666002993669873 20 2858827 SGTC_1524 corynanthine 62.1 µM 3.19210188337628 0.000535901564309663 yes 43 0.000706207514466865 47 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_643 k048-0106 28.4 µM 3.18793810285907 0.000544007639628887 yes 44 0.000716456031710676 27 6763920 SGTC_1210 3013-0140 750 nM 3.15811418095015 0.000605467680073419 yes 45 0.000793966744198992 27 905973 SGTC_1261 0712-0010 12.7 µM 3.06279404084315 0.000847503752174198 yes 46 0.0010964046260837 62 2840123 SGTC_2106 5357045 167.29 µM 3.04802876408218 0.000892117106239211 yes 47 0.0011517393872271 52 668842 SGTC_1905 st060207 84.5 µM 2.95586106303131 0.00122298827860891 no 48 0.00155898755375197 39 1948547 SGTC_3042 9091578 49.47 µM 2.95528094641975 0.00122538700064326 no 49 0.00156192221119214 29 25236497 SGTC_2356 9061756 188.97 µM 2.91849883791102 0.00138656473188871 no 50 0.00175860593129531 38 20104043 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.9056719416357 0.00144717661342809 no 51 0.00183232721927816 146 6708739 YPR165W RHO1 SGTC_2298 7976326 193.81 µM 2.88266750121256 0.00156197245027635 no 52 0.00197161713056286 40 2235818 SGTC_2308 7584454 197.62 µM 2.86048265092813 0.00168048176141069 no 53 0.00211498348272882 90 893577 SGTC_1830 st055982 50.3 µM 2.84467087694787 0.00176988251802884 no 54 0.00222286664893121 76 455313 An antimicrobial agent. SGTC_2852 9023854 51.95 µM 2.81627736755349 0.00194135230002404 no 55 0.00242918511998942 81 19798528 SGTC_1414 3917-0015 5.4 µM 2.80216560885641 0.00203206950649348 no 56 0.00253804043815084 51 6618702 SGTC_2143 5623677 140.463 µM 2.7810868757549 0.00217475225072828 no 57 0.00270886184151422 34 5375313 SGTC_1516 st013856 110 µM 2.76670711881707 0.00227723728048557 no 58 0.00283128010813784 55 5281404 A mutagen and neurotoxin. SGTC_3259 9138485 49.47 µM 2.74544508800257 0.00243680046730081 no 59 0.00302144396994988 68 17646153 SGTC_2119 5528445 120.635 µM 2.72766177222502 0.00257795096056491 no 60 0.00318924863724399 85 791935 SGTC_1906 st060206 94.7 µM 2.67664456899206 0.00302481746967892 no 61 0.00371817381028611 97 5133468 SGTC_507 nimesulide 162 µM 2.67368348958335 0.00305277883498311 no 62 0.00375116107502961 88 4495 A COX2 inhibitor. SGTC_2337 9009472 200 µM 2.67110593908096 0.0030773078418495 no 63 0.00378008911082543 114 5742383 SGTC_820 1582-0060 59.9 µM 2.66437676458602 0.00314218403079783 no 64 0.00385655607465012 107 3848840 SGTC_2436 5633522 8.09 µM 2.63877740451607 0.00340038775932569 no 65 0.00416027972565771 90 5724242 SGTC_1660 st012960 28.1 µM 2.63260416913537 0.00346543924746604 no 66 0.00423665173812277 123 24207266 SGTC_1600 coumarin 106 71.1 µM 2.63081211850308 0.00348453150537795 no 67 0.00425905561974104 107 100336 A hepatotoxic, DNA x-linker. SGTC_788 1182-0090 188 µM 2.62650391169685 0.0035308176677394 no 68 0.00431335004734805 200 5715185 SGTC_1242 0402-0103 60.1 µM 2.62610768404671 0.00353510222507784 no 69 0.00431837446397752 99 432868 SGTC_2257 7960413 200 µM 2.60284444787675 0.00379498772753247 no 70 0.00462269454368042 157 2974689 YIL048W NEO1 SGTC_3191 9110352 49.47 µM 2.59153216101967 0.00392744859643989 no 71 0.00477748051040998 81 17122424 SGTC_3330 9141424 71.43 µM 2.58373180553767 0.00402118391621582 no 72 0.00488688816460781 95 27261020 SGTC_1940 st075990 51.1 µM 2.5403964234607 0.00457933924329405 no 73 0.00553634425296383 131 1084979 SGTC_1214 0358-0031 63.7 µM 2.52711013881957 0.00476380386491949 no 74 0.00575027151024771 117 4301366 SGTC_2149 5554786 194.827 µM 2.50466000451507 0.00509059465644048 no 75 0.00612845761495205 146 745063 YPR165W RHO1 SGTC_955 1216-0110 33 µM 2.50421452714504 0.00509727632892738 no 76 0.00613617985860149 187 3619719 SGTC_737 1950-0117 57.9 µM 2.50060299597232 0.00515173420281107 no 77 0.00619910379451834 111 5393513 SGTC_1209 2323-2347 50.3 µM 2.49932424415062 0.0051711401327844 no 78 0.00622152018738307 84 5412760 SGTC_550 4123-0385 25.7 µM 2.49619543030115 0.0052188965920952 no 79 0.00627667095979862 138 5731123 SGTC_391 gliotoxin 8.33 µM 2.48599837960811 0.00537727357376399 no 80 0.00645942769166307 169 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1815 st051655 58.2 µM 2.46122182752775 0.00578003116877521 no 81 0.00692323626956639 72 5984156 SGTC_1840 st055363 71 µM 2.45140418919763 0.00594688644629631 no 82 0.00711500320571212 94 676033 SGTC_2666 tannic acid 100 µM 2.436097790354 0.00621555192332586 no 83 0.00742333510446245 152 16134267 A thiamine antagonist. SGTC_2456 5770359 74.46 µM 2.42680606055968 0.00638383904144146 no 84 0.00761619807081544 113 3118787 SGTC_2635 hydroquinidine 100 µM 2.42007217537639 0.00650830748432957 no 85 0.00775871341093232 113 442912 An experimental heart treatment. SGTC_128 0906-2981 13.371 µM 2.41242850715616 0.0066521892607382 no 86 0.00792332246441342 101 6740226 SGTC_2035 5154463 94.595 µM 2.4048568231464 0.00679748099533588 no 87 0.00808940152978661 143 2769623 SGTC_311 1315-0136 58 µM 2.39887996615633 0.00691414251927987 no 88 0.0082226522934878 101 6759207 SGTC_2075 5212009 200 µM 2.39594174723606 0.00697213876224665 no 89 0.00828886236797721 95 780898 SGTC_3019 9081971 49.47 µM 2.39370060136117 0.00701666406805019 no 90 0.00833967885220792 108 16451803 SGTC_1044 1222-0021 1.78 µM 2.38824544458949 0.00712609327784752 no 91 0.008464515735808 157 4306703 SGTC_2341 7987486 176.74 µM 2.37935620422259 0.00730763689507683 no 92 0.00867145401386261 150 1258686 SGTC_1842 st055362 61.2 µM 2.36670384092226 0.00757306315248165 no 93 0.00897364399983623 138 676032 SGTC_1884 5633444 25 µM 2.36574984738584 0.00759341638442607 no 94 0.00899679883910521 178 5724239 SGTC_491 tetrandrine 80.3 µM 2.35924135923856 0.0077335632687345 no 95 0.00915617055155655 84 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_696 1560-0013 611 µM 2.35564836204356 0.00781190220618073 no 96 0.0092452058398876 147 1650269 SGTC_988 1497-1057 103 µM 2.34897224769565 0.00795931858656911 no 97 0.00941265493802016 131 3533044 SGTC_284 0988-0104 32.6 µM 2.34500397932091 0.00804809693027096 no 98 0.00951343826381666 117 4666532 SGTC_1987 st072290 61.9 µM 2.29927803623093 0.00913560063520767 no 99 0.0107445781039259 131 54697379 SGTC_2986 9022445 71.43 µM 2.28625821384314 0.00946789838858362 no 100 0.0111195784576604 151 6459286 SGTC_3173 9105693 49.47 µM 2.27893439473915 0.00965942690768159 no 101 0.0113354827327535 170 17096658 SGTC_3182 9108849 49.47 µM 2.26726768380188 0.00997152308291734 no 102 0.0116869391729017 159 17133045 SGTC_1211 1056-0033 32.3 µM 2.26408719853552 0.0100581166178191 no 103 0.0117843760874966 121 6741922 SGTC_2074 5212007 75.395 µM 2.26198913139879 0.0101155982696923 no 104 0.0118490374047082 125 758611 SGTC_1167 k781-0610 148 µM 2.24958202241222 0.010461415110628 no 105 0.0122377453579451 188 4525169 SGTC_2353 9059630 146.67 µM 2.24797094737951 0.0105070670718354 no 106 0.0122890212665162 115 4779114 SGTC_366 0181-0206 4.31 µM 2.23728981486047 0.0108141447133768 no 107 0.0126337022334184 221 274874 SGTC_2374 9071832 200 µM 2.23522151740945 0.0108745018555108 no 108 0.0127014047626185 118 17381698 SGTC_966 1300-0360 30.2 µM 2.2183144212614 0.0113789747502131 no 109 0.0132667007816745 170 70588 SGTC_2110 5483698 200 µM 2.20417491865657 0.0118163612845748 no 110 0.013756022475943 154 2848765 YHR062C RPP1 SGTC_823 0417-1665 178 µM 2.19443306135264 0.0121261344527595 no 111 0.0141021456429375 183 3429856 SGTC_1323 1348-1351 11.2 µM 2.19238268306164 0.0121922221058233 no 112 0.0141759429819891 132 6989654 SGTC_2671 danthron 100 µM 2.18004165165417 0.012596628109127 no 113 0.0146271871145532 196 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_532 1548-0774 215 µM 2.17888651939485 0.0126350684917799 no 114 0.0146700497274571 173 5932993 SGTC_1731 st035964 63 µM 2.17801968190786 0.0126639816703737 no 115 0.0147022857372577 186 6739575 SGTC_2093 5331342 194.4 µM 2.17160221698434 0.0128798214048763 no 116 0.014942839829771 157 33839 SGTC_2862 9027634 71.43 µM 2.16905824306344 0.0129662598259264 no 117 0.0150391311793406 176 5012562 SGTC_2610 ononetin 44.17 µM 2.15810004776048 0.0133443518111984 no 118 0.0154600270269117 242 259632 SGTC_3175 9106517 49.47 µM 2.13411177414367 0.0142053879789937 no 119 0.0164168161513501 152 41468073 SGTC_3041 9091929 49.47 µM 2.13243442436848 0.0142673460728954 no 120 0.0164855749794547 193 25236887 SGTC_1007 4101-0031 70 µM 2.12289085505289 0.01462431490107 no 121 0.0168814994783695 176 1146276 SGTC_503 tyrphostin 8 294 µM 2.1044692357106 0.0153351310881119 no 122 0.017668767733561 210 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1312 1218-2183 165 µM 2.10391170503449 0.015357098626001 no 123 0.0176930748768489 161 6744073 SGTC_1687 st020778 55.3625 µM 2.08827712236058 0.0159842219390062 no 124 0.0183864219578615 390 4259299 SGTC_2749 bexarotene 57.39 µM 2.08807907555697 0.0159923046054295 no 125 0.0183953511057619 229 82146 An retinoic acid receptor inhibitor. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.08228016724662 0.0162305270605976 no 126 0.0186584431864193 182 279621 SGTC_3018 9082602 49.47 µM 2.07651396447802 0.0164704136589162 no 127 0.0189232204709009 203 17332089 SGTC_2246 7293507 91.5585 µM 2.07608613233579 0.0164883327445704 no 128 0.0189429927611303 210 887656 SGTC_1259 0671-0132 43 µM 2.06006428380455 0.0171715022801297 no 129 0.0196961978742938 209 X1259 SGTC_70 0141-0289 43.283 µM 2.05274699952198 0.0174914690376618 no 130 0.0200485606039451 474 352408 SGTC_2024 5144227 134 µM 2.05129732917436 0.0175554600633015 no 131 0.0201190002127175 231 3475211 SGTC_3013 9080133 71.4286 µM 2.04354491290988 0.0179010673904337 no 132 0.0204992630483166 230 17050193 SGTC_3146 9095609 49.47 µM 2.03956699740579 0.0180806466905255 no 133 0.0206967359592039 189 17173999 SGTC_2995 9067767 71.4286 µM 2.03631660478475 0.0182285205974991 no 134 0.020859286754123 178 11673567 SGTC_1813 st051246 8.6015 µM 2.01511882971876 0.0192183912978351 no 135 0.0219460998654759 166 5291959 SGTC_1569 carminic acid 40.6 µM 2.00311360099024 0.0197990010957595 no 136 0.0225825482229745 221 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2109 5483026 200 µM 2.00041817656818 0.0199313872736754 no 137 0.0227275636306051 252 759335 SGTC_1831 st055328 12 µM 1.99831792732551 0.0200350612613135 no 138 0.0228411015664722 228 1103068 SGTC_1370 2001-0092 44.6 µM 1.99272504324467 0.0203133745588127 no 139 0.0231457817729647 271 790957 SGTC_538 2922-0838 53.3 µM 1.99201187003124 0.0203490979976437 no 140 0.0231848777597991 276 777039 SGTC_1711 st032263 62.8 µM 1.97774714880812 0.0210748916809191 no 141 0.0239786192094744 201 3958979 SGTC_1685 st024049 53.0905 µM 1.96514735295159 0.0217340761947871 no 142 0.0246985926479026 191 1941139 SGTC_2823 7987624 58.44 µM 1.95644746661421 0.0221993246002062 no 143 0.0252062325981038 282 2239440 SGTC_3244 9134489 49.47 µM 1.95408914050841 0.0223268803533632 no 144 0.0253453380678716 233 16584271 SGTC_53 0973-0023 39.979 µM 1.95117382355522 0.0224854163418775 no 145 0.025518185867309 210 674768 SGTC_1847 st056231 15 µM 1.94776065265587 0.0226722310533686 no 146 0.0257218044580488 288 5393180 SGTC_848 0368-0089 85.6 µM 1.94465802941236 0.0228431818787949 no 147 0.0259080750525407 239 762535 SGTC_628 1636-0253 16 µM 1.94133497115259 0.0230274816408874 no 148 0.0261088301699877 273 4456143 SGTC_3279 9140807 49.47 µM 1.94001401132944 0.0231010902917347 no 149 0.0261889935512233 186 45595718 SGTC_361 000s-0510 1.45 µM 1.93298939393587 0.023495863553731 no 150 0.0266187521823028 270 660 SGTC_3038 9091290 49.47 µM 1.92241019206835 0.0241010994161244 no 151 0.0272770820675835 226 25236843 SGTC_326 k292-0812 17.5 µM 1.91474785645665 0.0245475946115231 no 152 0.0277623336171663 182 3579357 SGTC_844 0330-0132 15.3 µM 1.91020955866872 0.0248153063674666 no 153 0.0280531184617922 232 2828079 SGTC_611 3453-1652 23.7 µM 1.90914503470352 0.0248784554000043 no 154 0.0281216922866599 290 1560575 SGTC_548 1436-0017 110 µM 1.90858894964281 0.02491149668485 no 155 0.0281575692777529 301 9677137 SGTC_1057 3448-5381 134 µM 1.90430492726835 0.0251672790745584 no 156 0.0284352414471913 261 5497911 SGTC_2331 7980721 200 µM 1.90328838387995 0.0252282949866741 no 157 0.0285014628716685 270 2981221 SGTC_2837 9008476 45.46 µM 1.90149667708308 0.0253361402513527 no 158 0.0286184936671536 282 2992805 SGTC_2913 7966556 36.57 µM 1.90104318315832 0.025363497831135 no 159 0.0286481783056228 212 2976516 SGTC_1811 st050069 61.5 µM 1.89799082439285 0.0255482796482189 no 160 0.0288486453752333 179 3877702 SGTC_68 0986-0284 82.829 µM 1.89745450229349 0.0255808633365428 no 161 0.0288839890963717 307 423278 YIL048W NEO1 SGTC_1498 4478-3555 97.6 µM 1.89539675971926 0.0257062023578803 no 162 0.0290199288311741 170 3437919 SGTC_1507 4075-3230 155 µM 1.88943727048203 0.0260721038199121 no 163 0.0294166303931569 183 659771 SGTC_2525 harmine 47.85 µM 1.88639563810425 0.0262605270308484 no 164 0.0296208299637229 184 5280953 A monoamine oxidase inhibitor SGTC_1698 5-fluorocytosine 1.055 µM 1.88518608202996 0.026335772394484 no 165 0.0297023596113926 213 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2165 5727197 32.143 µM 1.87732873995479 0.0268289702245774 no 166 0.0302365257679138 290 1361712 SGTC_2229 7354935 190 µM 1.87476859311688 0.0269913245817681 no 167 0.0304122828365403 170 318112 SGTC_2656 pseudo-anisatin 100 µM 1.8691395796908 0.0273511793071232 no 168 0.0308016988411449 167 6708809 A neurotoxin. SGTC_2603 homopterocarpin 100 µM 1.86115784607693 0.0278682919126579 no 169 0.0313609446453475 300 101795 A weak amylase inhibitor. SGTC_2055 5235184 200 µM 1.86066965333208 0.0279001830055786 no 170 0.0313954209337877 273 2836034 SGTC_1619 st003326 88.7 µM 1.85386785525415 0.0283476802988244 no 171 0.0318790338636836 206 2849032 SGTC_2930 9013230 14.89 µM 1.85079487122433 0.0285518052859041 no 172 0.0320995346032512 314 2995857 SGTC_1433 4060-0023 7.6 µM 1.83998449195846 0.0292796313959037 no 173 0.0328852570713051 258 3840627 SGTC_2568 diosmetin 100 µM 1.83425432200126 0.02967163135596 no 174 0.0333081256019754 284 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3209 9113616 49.47 µM 1.83085039556021 0.029906548442181 no 175 0.0335614379770871 287 16649353 SGTC_3303 9125618 40.5795 µM 1.81486706301781 0.0310303343861584 no 176 0.0347721706377946 350 22695467 SGTC_2462 5162487 171.77 µM 1.81334415026561 0.0311392098693552 no 177 0.0348893788771825 266 2259986 SGTC_1377 2944-0135 198 µM 1.81298735081168 0.0311647636779047 no 178 0.0349168861470815 315 1894137 SGTC_1447 4239-0816 81.9 µM 1.79966969431922 0.0321310463012026 no 179 0.0359564045520203 283 1341554 SGTC_754 3474-0146 171 µM 1.79484082332522 0.0324874665519297 no 180 0.0363395322587472 281 24762078 SGTC_1915 st067105 30.6 µM 1.78961242334428 0.0328770471576373 no 181 0.0367581199608446 322 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2086 5274770 176.623 µM 1.78169064473774 0.0334746485011915 no 182 0.037399846665871 296 689278 SGTC_2856 9022925 19.48 µM 1.77148490486744 0.0342576997171937 no 183 0.038240050344696 307 4944862 SGTC_3174 9107204 49.47 µM 1.77102202077676 0.0342935691625193 no 184 0.0382785199612664 298 3938802 SGTC_669 0108-0021 26.2 µM 1.7687601438336 0.0344692889371131 no 185 0.0384669553067335 444 17201 SGTC_1618 st003135 44.5 µM 1.76216659754471 0.0349857510390611 no 186 0.0390205769280334 253 1270615 SGTC_2000 st075254 36.4 µM 1.76178303222532 0.0350159895428461 no 187 0.0390529813141051 235 17234175 SGTC_720 r052-1644 49.9 µM 1.76098966533163 0.0350786029612946 no 188 0.0391200761021939 263 1422863 YOR257W CDC31 SGTC_1000 4048-0884 8.67 µM 1.75665217446175 0.035422548836498 no 189 0.0394885570149157 319 13040088 SGTC_2102 5377816 72.7585 µM 1.74474265638855 0.036381168058925 no 190 0.0405148372760884 309 1379702 SGTC_1029 k015-0030 64.7 µM 1.73887815199803 0.0368609570022409 no 191 0.041028098997852 320 2208316 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.73872822345657 0.0368732905099501 no 192 0.0410412895654224 154 4000243 SGTC_618 k072-0232 33.2 µM 1.7359397723579 0.0371032912677855 no 193 0.0412872421986246 279 5872756 YGL099W LSG1 SGTC_249 wiskostatin 11.211 µM 1.72652876342477 0.0378882130170308 no 194 0.0421261646210155 281 2775510 A n-wasp and actin depolymerizer. SGTC_316 k060-0003 58.6 µM 1.72343243237258 0.0381494045983119 no 195 0.0424051770648544 293 6152314 SGTC_2447 5741742 33.78 µM 1.72184922589709 0.0382835226108548 no 196 0.0425484173367892 337 1776504 SGTC_2999 9069765 71.4286 µM 1.72030228384248 0.0384149396526331 no 197 0.0426887542674277 318 2097066 SGTC_2205 7238770 200 µM 1.71691706383457 0.0387038065373481 no 198 0.0429971633131223 263 279867 SGTC_2096 5468907 200 µM 1.70775875471344 0.0394941798949506 no 199 0.0438405575500174 297 759785 SGTC_2164 5685496 200 µM 1.70735669097282 0.0395291771355442 no 200 0.0438778874803289 307 759046 SGTC_2621 lithochol-11-enic acid 100 µM 1.70088368987221 0.0400960931165219 no 201 0.0444824149480391 373 6708711 SGTC_2295 7971645 200 µM 1.69741554039895 0.0404025465997556 no 202 0.0448090632761309 339 2978226 YKL099C UTP11 SGTC_658 3253-0951 102 µM 1.68962037415179 0.0410982884229444 no 203 0.0455503027644272 444 1184878 SGTC_1605 st000082 49.1 µM 1.68114556633434 0.0418656803331465 no 204 0.0463673217657973 301 1114022 SGTC_624 k048-0052 28 µM 1.6791484191347 0.0420482005364785 no 205 0.0465615608614885 310 6835531 SGTC_2363 9053361 176 µM 1.67718313940999 0.0422284365718243 no 206 0.0467533375156681 361 6469797 YMR079W SEC14 SGTC_2490 carminic acid 95.39 µM 1.66866940550037 0.0430164643782022 no 207 0.0475914578063521 249 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_188 3229-0966 278.469 µM 1.66861482625195 0.0430215542770648 no 208 0.0475968693368608 404 5722370 SGTC_525 k781-2675 26.7 µM 1.66800385259245 0.0430785650852729 no 209 0.0476574809988305 383 3651118 YDL195W SEC31 SGTC_1962 st076595 64.5 µM 1.66420674371404 0.0434342482471408 no 210 0.0480355604402702 350 279619 SGTC_2504 purpurogallin 52.29 µM 1.65666749430284 0.0441474912581813 no 211 0.0487933591708545 317 5281571 An antioxidant. SGTC_1106 tegaserod maleate 11.7 µM 1.65527731897486 0.0442800327758922 no 212 0.0489341287628868 379 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1204 4049-0315 18.3 µM 1.65320759044642 0.0444779579806639 no 213 0.049144311106997 350 588402 SGTC_2198 6589944 200 µM 1.64649085782533 0.0451251838848799 no 214 0.0498313703828947 264 5290268 SGTC_2435 5706476 10.6 µM 1.64157020445493 0.0456041321973842 no 215 0.0503395533684981 374 5725375 SGTC_1501 4491-0275 38.4 µM 1.64104846450662 0.0456551541416249 no 216 0.0503936776331819 322 5104718 SGTC_1688 st021091 57.6 µM 1.64023310186096 0.0457349818932051 no 217 0.0504783545810261 300 3656366 SGTC_940 3232-1287 54.8 µM 1.63617355192697 0.0461341017460092 no 218 0.0509016350241883 344 1585493 YIL048W NEO1 SGTC_2687 chenodiol 100 µM 1.63465770605106 0.0462838494912332 no 219 0.0510604116560433 332 5702181 A cholesterol synthesis inhibitor. SGTC_1568 digitonin 820 nM 1.63061694127727 0.0466849369532714 no 220 0.0514855860987122 392 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_415 dibenzyl ketone 100 µM 1.62609084867909 0.0471375044223025 no 221 0.0519651652532716 339 7593 SGTC_2015 5119600 184 µM 1.62030208947732 0.0477214451578059 no 222 0.0525837001477101 359 2828786 SGTC_701 4424-0219 185 µM 1.61989242326993 0.0477629887285616 no 223 0.0526276938554555 380 2911779 SGTC_1521 st012942 49.4 µM 1.61357161653768 0.0484076488587855 no 224 0.0533101887644718 404 24207259 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.61077896589255 0.0486946794628578 no 225 0.0536139536129845 440 368090 SGTC_3000 9075062 71.4286 µM 1.60868800590273 0.0489104791646873 no 226 0.0538422898744924 347 17057871 SGTC_3078 9116413 49.47 µM 1.60867374638668 0.0489119534519962 no 227 0.0538438496764508 339 17177322 SGTC_432 NS 1619 61.3 µM 1.60790289557063 0.0489917043553029 no 228 0.0539282237952362 340 4552 A K+/calcium channel activator. SGTC_2219 9098279 200 µM 1.60653092297336 0.0491339032471187 no 229 0.0540786531137564 333 902349 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.60351121760362 0.0494480436108097 no 230 0.0544109172665494 353 803109 SGTC_917 harmaline 728.087 nM 1.59673056392947 0.0501592780737903 no 231 0.0551628898100033 388 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2318 6029776 164 µM 1.59395716970025 0.0504525240261153 no 232 0.0554728141297589 393 818325 SGTC_2641 levomentholum 100 µM 1.59188519572772 0.0506724952001887 no 233 0.0557052512729033 287 16666 SGTC_2782 7736369 71.43 µM 1.58986679686272 0.0508875123713283 no 234 0.055932416663215 411 2950836 YOL077C BRX1 SGTC_2444 5485484 36.41 µM 1.58473036199042 0.0514379664285973 no 235 0.056513805193536 395 6790631 SGTC_2516 gossypol 71.55 µM 1.58240212198261 0.0516890307032108 no 236 0.0567789003084039 387 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2355 9061122 103.12 µM 1.58149397698159 0.0517872236393769 no 237 0.0568825675077005 348 5302957 SGTC_533 1222-0222 6.71 µM 1.57928068948393 0.0520271557757067 no 238 0.0571358445594164 415 3982874 SGTC_529 4076-0302 30.3 µM 1.57831986411755 0.0521315888842913 no 239 0.0572460723489909 390 5816522 SGTC_155 k072-0202 43.6 µM 1.57700908927644 0.0522743268068788 no 240 0.0573967168398823 340 5857737 SGTC_852 0418-0143 439 µM 1.57678780869698 0.0522984539305953 no 241 0.057422178876868 469 5369229 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.57573666581046 0.0524131851170289 no 242 0.0575432518599093 418 804 An inhibitor of viral and cellular DNA polymerases. SGTC_779 1360-0071 233 µM 1.57208203722297 0.0528136399322344 no 243 0.0579657633808174 412 7566 SGTC_1279 0874-0590 65.2 µM 1.5650542065934 0.0535905310746547 no 244 0.0587850998635497 384 3523074 SGTC_763 3453-1109 128 µM 1.5647301065688 0.0536265759194558 no 245 0.0588231030468902 394 1560353 SGTC_1928 4'-methoxychalcone 40.3 µM 1.56111880914411 0.0540295074683411 no 246 0.0592478604562565 362 641818 SGTC_1919 st067113 52.3 µM 1.56084074698959 0.054060631432331 no 247 0.059280665333598 417 1268243 SGTC_3265 9137266 49.47 µM 1.55574586034022 0.0546334266073168 no 248 0.0598842683350393 320 17224265 SGTC_2466 5983409 37.09 µM 1.54819993095761 0.0554905861105766 no 249 0.0607870840183099 392 2879657 SGTC_1378 2093-0007 380 nM 1.54501354735934 0.0558557078890452 no 250 0.0611714932671632 410 3618014 SGTC_193 1273-0060 1.558 µM 1.54208093797103 0.0561934226988294 no 251 0.0615269632463506 302 2847393 YHR072W ERG7 SGTC_1179 1021-1431 9.29 µM 1.53897203507413 0.0565531951202829 no 252 0.061905561743262 488 2840958 SGTC_492 tmb-8 126 µM 1.53437513820403 0.0570884861123615 no 253 0.0624686951578353 229 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2929 9013348 24.6 µM 1.53005700938537 0.0575949410455836 no 254 0.0630013091311227 412 2995952 SGTC_1630 st005209 31.3 µM 1.52184423364857 0.0585679278352472 no 255 0.0640240575269313 446 3367314 SGTC_60 0986-0278 202 µM 1.51664091885434 0.0591910245143072 no 256 0.0646786841955857 298 3110598 SGTC_46 0329-0187a 2.197 µM 1.51479550536954 0.059413257382421 no 257 0.0649120995361066 526 46494817 SGTC_75 0159-0059 199.013 µM 1.50848884828097 0.0601776731269682 no 258 0.0657147293439817 397 5377270 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.50317237611663 0.0608280333889715 no 259 0.0663972994755186 449 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3214 9129694 49.47 µM 1.50107577306622 0.0610860154090972 no 260 0.0666679821110774 395 17158655 SGTC_734 2023-0417 80 µM 1.48378370707985 0.063246496650478 no 261 0.0689331554292915 443 3935732 SGTC_1199 1638-0010 4.46 µM 1.48250830685402 0.0634081724353058 no 262 0.0691025474740898 471 3111136 SGTC_2920 7982904 15.77 µM 1.48077082192198 0.0636289416859479 no 263 0.0693338271330101 372 6456808 SGTC_3260 9137109 49.47 µM 1.47487619152981 0.0643823868220694 no 264 0.0701229161482918 332 17478346 SGTC_117 lucigenin 22.078 µM 1.47443381455984 0.0644392094332445 no 265 0.0701824128084504 510 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1565 sinapyl alcohol 95.1 µM 1.47442158159887 0.0644407812908966 no 266 0.0701840586090894 425 5280507 A phenol propionate derived from cinnamic acid. SGTC_513 4245-1575 41.7 µM 1.47437526108111 0.0644467334526767 no 267 0.0701902907575189 600 719745 SGTC_3235 9132602 49.47 µM 1.47360722293836 0.0645454882147623 no 268 0.0702936877423904 470 4912240 SGTC_1039 k821-0043 94 µM 1.46966665003401 0.0650540191008067 no 269 0.070826029659121 439 15992768 SGTC_1581 himbacine 57.9 µM 1.46925626220742 0.0651071579311997 no 270 0.0708816475885228 469 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1635 st007035 42.4 µM 1.468549361328 0.0651987695596449 no 271 0.0709775291996419 652 3716403 SGTC_2225 6654152 15.4 µM 1.46554577976361 0.0655891378920618 no 272 0.0713860359027167 344 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2905 7799065 20.05 µM 1.46405251854182 0.0657838867628589 no 273 0.0715897996143361 393 1296806 SGTC_2126 5251174 33.877 µM 1.46304220596674 0.0659159042115963 no 274 0.0717279152283082 541 790722 SGTC_2835 9006588 71.43 µM 1.46280971971798 0.0659463122062738 no 275 0.0717597263625261 460 2345538 SGTC_2457 5731572 11.68 µM 1.46244441724424 0.0659941138310294 no 276 0.0718097326230457 413 2865357 SGTC_2107 5363541 170.161 µM 1.45738499134023 0.0666589287176646 no 277 0.0725050688439693 451 244052 SGTC_343 4130-2827 29.8 µM 1.45540929190586 0.066919940868534 no 278 0.072777992768244 470 1118244 SGTC_3342 9147791 14.508 µM 1.452545269516 0.0672997133413196 no 279 0.0731750256992474 436 1838168 SGTC_1265 0819-1001 68.8 µM 1.44719401330795 0.0680137578312672 no 280 0.0739212964050807 438 3106768 SGTC_1395 3486-0190 4.35 µM 1.44709639760698 0.0680268372883826 no 281 0.0739349634191237 474 6748079 SGTC_1174 0739-0097 51.1 µM 1.4469530486892 0.0680460480257832 no 282 0.0739550369652647 474 728447 SGTC_102 gallobenzophenone 83.616 µM 1.44108085625445 0.0688366085371643 no 283 0.0747809206018472 481 70837 SGTC_2006 4011487 200 µM 1.44004484849337 0.0689768159409373 no 284 0.0749273554728745 513 45595294 SGTC_825 1988-2224 89.6 µM 1.43340104070028 0.0698811887109144 no 285 0.0758716305841653 494 1180859 SGTC_1920 st075728 45.7 µM 1.43301265837757 0.0699343373218905 no 286 0.0759271099274786 447 3400306 SGTC_1085 doxorubicin 7.67 µM 1.432574596978 0.0699943216424022 no 287 0.0759897228550602 513 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_383 2324-0395 7.37 µM 1.42738701324931 0.0707076776246929 no 288 0.0767341860327238 486 3146421 SGTC_2056 5235370 200 µM 1.42646481611245 0.0708350737842296 no 289 0.0768671079324451 488 5511916 SGTC_33 0986-0033 35.816 µM 1.42190484935923 0.0714675998361674 no 290 0.0775269376185261 416 2848082 SGTC_1714 st033236 13.627 µM 1.41479106958533 0.07246301621032 no 291 0.0785648816350618 500 2916566 SGTC_1061 3448-9325 110 µM 1.41326689364299 0.0726776661117029 no 292 0.0787886321727948 426 723482 SGTC_1026 k007-1105 30.6 µM 1.41307786831663 0.0727043204765086 no 293 0.0788164148967516 568 7066794 SGTC_2836 9010338 19.48 µM 1.41207337937652 0.0728460885493278 no 294 0.0789641780588569 440 2994051 SGTC_656 4090-1979 187 µM 1.41125193551233 0.0729621798618102 no 295 0.0790851706565144 518 22330961 SGTC_710 3448-4187 58 µM 1.41102988106332 0.0729935862130789 no 296 0.0791179017257026 582 3946412 SGTC_2606 farnesol 9.78 µM 1.41007809700273 0.0731283193688162 no 297 0.0792583119635554 485 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3132 9126706 49.47 µM 1.4053160133607 0.0738052925112779 no 298 0.0799636643282993 440 850858 SGTC_985 1493-0307 8.71 µM 1.404746241461 0.0738866105114803 no 299 0.0800483749798735 404 3278274 SGTC_2820 7989630 71.43 µM 1.40129945367081 0.0743799975967196 no 300 0.0805622722550844 385 2984098 SGTC_742 0kpi-0133 140 µM 1.39628746590529 0.0751019168499244 no 301 0.0813139733550312 500 2728852 SGTC_3245 9134821 49.47 µM 1.39604773571588 0.0751365806585186 no 302 0.0813500603865987 495 17014901 SGTC_1208 2323-2347 50.3 µM 1.396006957952 0.0751424781368911 no 303 0.0813561999413311 469 5412760 SGTC_2757 clomiphene 4.22 µM 1.39431604490579 0.0753873370960085 no 304 0.0816110939223693 558 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1554 st069299 38.7 µM 1.39244014621588 0.0756596946562955 no 305 0.081894577294999 491 24207999 SGTC_1280 0880-0253 10.1 µM 1.38676547202724 0.0764881520186547 no 306 0.0827566444394295 508 6836607 SGTC_164 4100-3994 89.624 µM 1.38301261703987 0.0770398183409546 no 307 0.0833304986249691 551 4615967 SGTC_1317 1273-0028 910 nM 1.38246211641696 0.0771209951216763 no 308 0.0834149273977593 487 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1673 st016611 27.3 µM 1.38192698917804 0.0771999672289168 no 309 0.0834970600076773 514 5226799 SGTC_705 1124-0212 310 µM 1.38191572026181 0.0772016309143869 no 310 0.0834987902410739 510 9554485 SGTC_2810 7959871 45.46 µM 1.3808248951308 0.0773628037636674 no 311 0.083666403490386 565 2974535 SGTC_1023 4482-3888 16 µM 1.38042236671223 0.0774223431194292 no 312 0.0837283187312745 466 3303168 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.36915799505854 0.0791026432618467 no 313 0.0854749465099881 486 7104 SGTC_1387 3342-1166 1.8 µM 1.3663893504085 0.0795198378344863 no 314 0.0859083948061522 409 3418228 SGTC_1796 st049173 110.4 µM 1.3641333850404 0.0798610084582756 no 315 0.0862627945905529 421 94134 SGTC_1412 3909-8563 178 µM 1.36299926065004 0.0800329401798116 no 316 0.0864413718126387 555 23767530 SGTC_898 1000-0849 28.3 µM 1.35895057800753 0.0806489980887507 no 317 0.0870811250382983 508 6751807 SGTC_2426 5582046 32.21 µM 1.35864916267151 0.0806950050641503 no 318 0.0871288942867048 525 2251934 SGTC_2598 perillyl alcohol 100 µM 1.35777473435148 0.080828586876319 no 319 0.0872675871635534 511 10819 An apoptosis inducer. SGTC_1428 4049-0204 61.7 µM 1.35772411955944 0.080836324140283 no 320 0.0872756202079179 512 X1428 SGTC_2190 6049624 200 µM 1.3567856730523 0.0809798817088327 no 321 0.0874246605359222 431 2265554 SGTC_1084 voriconazole 435 nM 1.35667476231461 0.0809968608343795 no 322 0.0874422874816465 504 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2036 5160441 105 µM 1.35359031532799 0.0814701304259721 no 323 0.0879335591942714 583 134534 YIL048W NEO1 SGTC_1001 4048-4355 44.4 µM 1.35014152003282 0.0820017709514715 no 324 0.0884852961517883 496 21824233 SGTC_3179 9107801 49.47 µM 1.35013692511707 0.0820024810088535 no 325 0.0884860329611615 498 4818259 SGTC_1876 myriocin 605 nM 1.34981134897278 0.0820528044424472 no 326 0.0885382517698455 501 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_981 1488-1094 54.9 µM 1.34803007433161 0.0823285432520713 no 327 0.0888243549482888 446 3449522 SGTC_3242 9133940 49.47 µM 1.34706299175704 0.0824785382360331 no 328 0.0889799729898814 497 17248444 SGTC_2361 9034121 116 µM 1.3430061828049 0.0831099935599857 no 329 0.0896349859175389 502 6496917 SGTC_2909 7941780 10.49 µM 1.34013474533321 0.0835591346047457 no 330 0.0901007709067553 521 1243215 SGTC_2278 7948257 134.34 µM 1.33990081627306 0.0835958052306248 no 331 0.090138796352095 505 1247028 SGTC_2312 7706453 155.7 µM 1.33876786785774 0.0837735768853418 no 332 0.0903231271577157 520 976098 SGTC_1004 4084-0029 199 µM 1.33844123516951 0.0838248817262845 no 333 0.0903763222775461 570 716894 YLR208W SEC13 SGTC_2887 9044784 58.44 µM 1.33635629252127 0.0841529240055132 no 334 0.0907164225557042 536 6465546 SGTC_3289 9119912 71.43 µM 1.33278422659667 0.0847171868033215 no 335 0.0913013117342878 508 17014829 SGTC_1354 1498-1681 81 µM 1.33182870054647 0.0848686067775726 no 336 0.0914582422710722 566 5754243 SGTC_2759 disulfiram 3.38 µM 1.33173949144377 0.0848827538845868 no 337 0.0914729036992312 513 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_607 4491-0986 66.8 µM 1.32908269403783 0.0853048893783496 no 338 0.0919103445721666 543 698981 YDR232W HEM1 SGTC_2799 7812892 81.82 µM 1.32717086814227 0.0856096289046444 no 339 0.0922260833566857 560 20205235 SGTC_2100 5377183 190 µM 1.32374043878746 0.0861584717712918 no 340 0.0927946316179625 570 2844202 SGTC_207 4185-0010 4.486 µM 1.32210514275529 0.0864210314065685 no 341 0.0930665707662078 608 3761753 SGTC_3054 9094397 49.47 µM 1.32194198430417 0.0864472605659712 no 342 0.0930937352434967 566 2598354 SGTC_477 mead ethanolamide 10 µM 1.31883890297684 0.0869472419312919 no 343 0.0936114876646707 351 16061185 SGTC_2458 5808907 16.39 µM 1.31875308779292 0.0869610994618858 no 344 0.0936258361730046 550 2731747 SGTC_1333 1482-0047 286 µM 1.31842835347326 0.0870135528522874 no 345 0.0936801472442121 574 3811116 SGTC_1984 st072354 53.1 µM 1.31600844965278 0.0874051773203168 no 346 0.0940856033263357 521 5762938 SGTC_2533 agelasine 13.65 µM 1.31306730714781 0.087882925738845 no 347 0.0945801345071413 573 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1268 0828-0275 2.46 µM 1.30880236462214 0.0885791632587569 no 348 0.0953006528858933 547 745337 SGTC_2980 9014342 25.29 µM 1.30831316122373 0.0886592860090201 no 349 0.0953835564550607 525 2996599 SGTC_1141 3253-0389 52.6 µM 1.3061791698389 0.0890094269281141 no 350 0.0957458173756904 524 5402031 SGTC_2346 9031566 143.75 µM 1.30470309218864 0.0892522202379895 no 351 0.0959969840776223 519 4771086 SGTC_1620 st003704 16.5 µM 1.30330468376965 0.0894826923112986 no 352 0.0962353813465455 543 2834414 SGTC_446 go6976 132 µM 1.30143162688542 0.089792084416852 no 353 0.0965553769431827 501 3501 A protein kinase C inhibitor. SGTC_1699 st031318 29.054 µM 1.30082140856952 0.0898930519973399 no 354 0.0966597961005221 528 5340658 SGTC_274 sirtinol 40.1 µM 1.29853641250817 0.0902718802505387 no 355 0.0970515361814857 538 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1408 3909-7976 48.8 µM 1.29232449972792 0.0913077414721733 no 356 0.0981223954581189 615 24152374 SGTC_1255 0566-0045 221 µM 1.29166091513979 0.0914189157089835 no 357 0.0982372992555801 572 2788469 SGTC_425 3825-7017 13.1 µM 1.2899059996572 0.091713410542623 no 358 0.0985416487098993 604 3397440 SGTC_3229 9132204 49.47 µM 1.28888729834605 0.0918846823351226 no 359 0.0987186352184667 484 17682924 SGTC_487 nimodipine 119 µM 1.28228607655602 0.0930002744403403 no 360 0.0998711552054998 443 4497 L-type voltage-gated calcium channels inhibitor SGTC_603 3794-0023 45.9 µM 1.28224976307606 0.0930064389075315 no 361 0.0998775223110515 538 3802260 SGTC_1749 st037932 54.2 µM 1.27985060390359 0.0934143824298357 no 362 0.100298841386009 528 594497 SGTC_2371 9071574 200 µM 1.27865776472849 0.0936176993381507 no 363 0.100508799378798 489 45596039 SGTC_1347 1493-0251 600 nM 1.2756425619972 0.0941330908418628 no 364 0.101040950644936 608 3986378 SGTC_45 0kpi-0036 14.9 µM 1.2748622998588 0.0942668020966588 no 365 0.101178992514183 527 2795021 SGTC_3110 9122132 49.47 µM 1.2735229553614 0.0944966481990225 no 366 0.101416266060516 571 918317 SGTC_2461 5755302 26.15 µM 1.27016510154348 0.095074708507082 no 367 0.102012912938835 607 2788904 SGTC_1295 1013-0063 9.78 µM 1.26831807246533 0.095393785985025 no 368 0.102342192847107 576 6826038 SGTC_1907 st060210 83.7 µM 1.26366546064373 0.0962010252071617 no 369 0.103175063587811 625 688793 SGTC_2167 5876490 200 µM 1.26300088386022 0.0963167395035623 no 370 0.103294431037483 574 686534 SGTC_1118 chelidonine 707.474 nM 1.26082736877523 0.0966959003517982 no 371 0.103685525429685 622 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_435 c-PAF 6.7 µM 1.25944414028021 0.096937769075999 no 372 0.103934977299168 606 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_542 3381-0244 89.3 µM 1.25843751091437 0.0971140654119746 no 373 0.104116786584981 650 1112843 SGTC_170 4197-0004 226 µM 1.25615064526554 0.0975154506199414 no 374 0.104530678489964 512 218692 SGTC_213 1246-0773 967 nM 1.25538085997088 0.0976508348363297 no 375 0.104670267059406 596 6251622 SGTC_2108 5365811 200 µM 1.25505706341831 0.0977078229687307 no 376 0.104729022840089 587 780283 SGTC_1597 7-benzyloxygramine 47.5 µM 1.25446502093 0.0978120853796884 no 377 0.104836516002687 713 260807 SGTC_2111 5486399 200 µM 1.25347365445448 0.097986853837565 no 378 0.105016690571929 639 689674 SGTC_664 1222-0054 14.9 µM 1.24857466823998 0.0988538585982642 no 379 0.105910341174049 605 6813991 SGTC_2681 menadione 3.18 µM 1.2483137616578 0.0989001898283209 no 380 0.105958088230023 577 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.24778439851414 0.0989942418117741 no 381 0.106055011815403 472 1241132 A phosphatase inhibitor. SGTC_621 3584-0052 32.1 µM 1.2466817349533 0.099190362170665 no 382 0.106257109321498 605 2273927 SGTC_1927 st060202 13.8 µM 1.24659746506081 0.0992053621395033 no 383 0.106272565842333 574 688887 SGTC_2477 5967686 25.23 µM 1.2458439545932 0.0993395600905033 no 384 0.106410844562693 569 776118 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.24428589836585 0.0996174660524872 no 385 0.106697179576457 644 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1556 plumbagin 1.48 µM 1.24389041016917 0.0996880984508848 no 386 0.10676994964653 509 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1282 0886-0010 32.4 µM 1.23685413375749 0.100950867869966 no 387 0.108070620279049 667 2836211 YNL267W PIK1 SGTC_3204 9114183 49.47 µM 1.23656649040269 0.10100273692457 no 388 0.108124033410977 557 17027248 SGTC_1560 lithocholic acid 53.1 µM 1.23540989268079 0.101211495577819 no 389 0.108338996442611 502 9903 A bile acid which acts as a detergent. SGTC_1817 st052116 64.4 µM 1.23346592675687 0.101563077287536 no 390 0.108700990765409 560 4361398 SGTC_59 0330-0160 1.33 µM 1.23227495058889 0.101778913700585 no 391 0.10892319685824 745 4293482 SGTC_1241 0364-0022 50.8 µM 1.22974859009092 0.102237862103847 no 392 0.10939563254367 634 4563895 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.22962199247769 0.102260899857541 no 393 0.109419345276785 569 5355888 SGTC_3105 9121040 49.47 µM 1.22760643676346 0.10262819177153 no 394 0.109797372168015 354 41448907 SGTC_2871 9038510 12.99 µM 1.22409474947012 0.103270410748906 no 395 0.110458243257982 650 4945164 SGTC_380 3970-0968 6 µM 1.22146763042037 0.103752763944812 no 396 0.110954507135495 579 2891601 SGTC_3188 9110789 49.47 µM 1.22043115618489 0.103943515116649 no 397 0.111150736235185 619 849217 SGTC_470 aa-861 153 µM 1.22031357178647 0.103965171226507 no 398 0.111173013429391 650 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2948 9070189 9.45 µM 1.21894691507912 0.104217115315652 no 399 0.111432170730124 540 6473636 YDL196W YDL196W SGTC_896 0964-0007 44.5 µM 1.21808113784398 0.104376950751398 no 400 0.111596570471062 627 6756758 SGTC_999 SEC7.066 22.7 µM 1.21794150629044 0.104402745452164 no 401 0.111623100914162 639 740511 YDR170C SEC7 SGTC_1653 st012112 65 µM 1.21562877499963 0.104830657690849 no 402 0.11206318376946 573 720429 SGTC_265 mycophenolic acid 32.932 µM 1.21402546832096 0.105128053344932 no 403 0.112368999428737 656 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1553 gossypol 38.6 µM 1.21251310607681 0.105409138974799 no 404 0.112658014384743 473 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1887 st057648 70.8 µM 1.2092523926368 0.106017019533816 no 405 0.113282947391026 618 688672 SGTC_1741 st038134 10.228 µM 1.20686883107869 0.106462976302967 no 406 0.113741331480361 659 1272587 SGTC_1465 k213-0056 144 µM 1.20611331094075 0.106604614006455 no 407 0.113886901551883 597 24048857 YMR208W ERG12 SGTC_317 4495-0002 170 µM 1.20468190986297 0.106873332277264 no 408 0.114163061114514 564 15991618 SGTC_1257 0669-0121 16 µM 1.20424163862054 0.106956083003029 no 409 0.114248098278533 674 4307855 SGTC_2994 9053520 71.4286 µM 1.20351613258782 0.107092545558875 no 410 0.114388326139601 614 4647384 SGTC_1470 k295-0292 231 µM 1.19790568676596 0.108152072419872 no 411 0.115476867814302 644 5045612 SGTC_1855 st056195 39.6 µM 1.19770901082437 0.108189350880247 no 412 0.115515160069164 607 4028379 SGTC_1122 capsaicin 818.572 nM 1.19666981381394 0.108386476486369 no 413 0.115717638593925 633 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1304 1165-0502 251 µM 1.19466975261622 0.108766595818739 no 414 0.11610804235215 676 767425 SGTC_1747 st037496 66.6 µM 1.18866091465989 0.109914362412239 no 415 0.117286563447274 658 723305 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.18646717199071 0.110335554229445 no 416 0.117718929129191 608 140250 A respiratory chain inhibitor. SGTC_253 dyclonine 31.25 µM 1.18623911960251 0.110379405905962 no 417 0.117763940716383 682 3180 An oral anasthetic. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.1851502715638 0.11058895029985 no 418 0.11797901879153 740 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2147 5545932 89.7195 µM 1.1784696107636 0.111880859357693 no 419 0.119304720274942 618 797404 SGTC_1240 0356-0016 42.1 µM 1.17523143741487 0.112510927608353 no 420 0.119951068059765 646 4305613 SGTC_357 1325-0123 420 µM 1.17053215618789 0.113429793033688 no 421 0.120893440721597 606 1098503 SGTC_2815 7968870 71.43 µM 1.16942869816305 0.113646329405953 no 422 0.121115476508754 674 2977326 YHR190W ERG9 SGTC_1989 st071868 50.2 µM 1.16712366716439 0.114099606025926 no 423 0.121580215682651 656 16414057 SGTC_840 0245-0196 390 µM 1.16582988073167 0.114354588338296 no 424 0.121841616748079 697 3827528 SGTC_1922 5578187 25 µM 1.1652051739846 0.114477852072582 no 425 0.121967975898733 618 1350412 SGTC_2811 7967822 32.47 µM 1.16224764841908 0.11506269869774 no 426 0.122567442496419 649 2232244 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.16193496085661 0.115124656202056 no 427 0.122630942366319 659 5377381 SGTC_2648 atorvastatin 78.68 µM 1.16013888939414 0.11548099839743 no 428 0.122996131422157 629 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.1573310572374 0.116039643950377 no 429 0.123568564709675 580 77254 SGTC_1490 4089-0339 670 nM 1.15573467205803 0.116358114405683 no 430 0.123894850762243 620 742542 SGTC_2536 dehydroabietamide 32.04 µM 1.15329225977538 0.116846562108026 no 431 0.124395223025733 700 3983547 SGTC_3338 9144300 39.5675 µM 1.151179914687 0.117270171651569 no 432 0.124829113245802 678 4901274 SGTC_336 4111-0029 111 µM 1.14455833465068 0.118605108456973 no 433 0.126196080087217 611 3131175 SGTC_1298 1079-1278 263 µM 1.1435728546592 0.118804699460731 no 434 0.126400412319823 705 2840950 SGTC_851 0394-0702 453 µM 1.1430550024662 0.118909676019594 no 435 0.126507877615061 725 762646 SGTC_1326 1431-2094 10.8 µM 1.14096671405416 0.119333668688566 no 436 0.126941887447707 682 616278 SGTC_2297 7971671 152.32 µM 1.13898249225173 0.119737519747957 no 437 0.127355228293552 655 909016 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.1359021561146 0.120366372065585 no 438 0.127998757921571 497 6708630 An antioxidant. SGTC_3114 9122766 49.47 µM 1.13559071008069 0.120430083202903 no 439 0.128063949322012 625 17176985 SGTC_2954 9074818 52.69 µM 1.1298616204494 0.121606296477456 no 440 0.129267269091445 655 16648742 SGTC_1829 berberine 14.4 µM 1.12918801355325 0.121745120277201 no 441 0.129409264541684 668 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2485 5633444 17.78 µM 1.12782099605531 0.122027191430086 no 442 0.129697762184752 659 5724239 SGTC_2286 7945697 125 µM 1.12777672810341 0.122036333369566 no 443 0.129707112006811 662 1245733 SGTC_1161 k007-0610 110 µM 1.12707669320554 0.122180964126353 no 444 0.129855028246614 777 5843850 SGTC_846 0335-0850 148 µM 1.12502686934261 0.122605160096855 no 445 0.130288824236666 665 6819598 SGTC_3061 glucosamine 200 µM 1.12266035342873 0.123096176858411 no 446 0.130790886112493 651 91431 and experimental redox chemotherapeutic SGTC_1140 3229-1848 2.98 µM 1.12054722488654 0.123535782975133 no 447 0.131240320032176 690 2849525 SGTC_831 k061-1017 217 µM 1.11735021048985 0.124202964184501 no 448 0.13192230738264 846 1240153 SGTC_2327 6189656 200 µM 1.11665483286434 0.124348414858673 no 449 0.13207096847973 680 5349088 SGTC_1713 st033146 12.748 µM 1.11652771473596 0.12437501676319 no 450 0.132098156874774 701 674619 SGTC_2968 9090663 33.37 µM 1.11459537279511 0.124779886462254 no 451 0.132511927060601 688 25236811 SGTC_1056 3448-1962 115 µM 1.11457364599342 0.124784443952425 no 452 0.132516584467117 663 715507 SGTC_2700 st077718 96.8 µM 1.11319996296675 0.125072828723027 no 453 0.132811279292735 642 904970 SGTC_558 k064-0027 21.3 µM 1.1129822557045 0.125118575893793 no 454 0.132858025208337 702 5088526 SGTC_228 caffeine 993.056 µM 1.11194597286733 0.125336491832888 no 455 0.133080690268287 650 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2397 5161689 200 µM 1.11115034639711 0.125503980774056 no 456 0.133251819948792 715 2259942 SGTC_2541 muurolladie-3-one 83.07 µM 1.1102390416385 0.125696013226706 no 457 0.133448016603484 670 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1132 3456-3614 2.5 µM 1.100787853289 0.127699682563033 no 458 0.135494499761457 807 3125502 SGTC_1181 1222-0449 220 µM 1.10012622136407 0.127840776609741 no 459 0.135638565256348 726 658318 SGTC_1758 st042942 75.2445 µM 1.09659725121224 0.128595164785045 no 460 0.136408744820374 721 669317 SGTC_2139 5578692 56.4705 µM 1.09452243285523 0.129040138178008 no 461 0.13686295711998 651 650991 YMR113W FOL3 SGTC_314 1671-0008 2.74 µM 1.09432270417868 0.129083029012144 no 462 0.136906735536226 743 3913060 SGTC_887 0885-0007 9.62 µM 1.09228503933582 0.129521173233287 no 463 0.137353917043573 737 5719458 SGTC_468 gf-109203x 121 µM 1.09177369356532 0.129631285719715 no 464 0.137466292259725 577 2396 A protein kinase C inhibitor. SGTC_714 4296-0578 26.1 µM 1.0908248294182 0.129835784562297 no 465 0.137674984382587 670 1589775 SGTC_3101 9120531 49.47 µM 1.09025542790422 0.129958608947033 no 466 0.137800321671786 722 24824904 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.08703900608365 0.130653926752811 no 467 0.138509785809796 663 5282362 SGTC_1748 st037455 53.6035 µM 1.08682665508138 0.130699922584609 no 468 0.138556712685529 722 580690 SGTC_212 3807-4682 38.772 µM 1.08646202433575 0.130778928753402 no 469 0.138637316719135 866 3125501 YBL034C STU1 SGTC_1735 st034310 56.75 µM 1.07499373768505 0.133280671369266 no 470 0.141188766028386 719 871153 SGTC_986 1493-0483 84 µM 1.06953120870466 0.134483795367812 no 471 0.142415186956382 730 40079 SGTC_275 trichlorophene 5.69 µM 1.06841404598084 0.134730766357091 no 472 0.142666891940309 864 62616 SGTC_2705 st078069 42.8 µM 1.06825051518228 0.134766944181544 no 473 0.142703761854287 673 1530061 SGTC_1679 SEC14.276 6.7 µM 1.06785008411091 0.134855559459404 no 474 0.142794070878532 772 1005053 YMR079W SEC14 SGTC_43 0570-0105 72.5 µM 1.06606060149317 0.135252059869093 no 475 0.143198124037204 822 1114046 YDL195W SEC31 SGTC_2088 5278280 127.392 µM 1.06509261566851 0.135466871809301 no 476 0.143417010281173 764 791502 SGTC_3024 9090631 49.47 µM 1.06481082425554 0.135529449861126 no 477 0.143480772925786 698 25236383 SGTC_2207 7258803 200 µM 1.06193658448313 0.136168870128997 no 478 0.144132237608242 686 3666799 SGTC_111 0083-0039 52.457 µM 1.06021038216098 0.136553882013951 no 479 0.144524449447049 616 759313 SGTC_2551 apiole 73.87 µM 1.05856809645321 0.136920867610265 no 480 0.144898261438773 601 10659 A possible DNA adduct former. SGTC_2161 5662504 8.5105 µM 1.0569066128882 0.137292828487869 no 481 0.145277105063704 708 2859334 SGTC_244 nsc-207895 1.295 µM 1.0568418016665 0.137307351925165 no 482 0.145291896504435 624 42640 SGTC_766 1391-0721 126 µM 1.054447196849 0.137844690495805 no 483 0.145839111807923 754 1020919 YIL115C NUP159 SGTC_929 2805-0021 398 µM 1.05165569292288 0.138472900288569 no 484 0.146478772969155 728 3098024 SGTC_2858 9025781 8.96 µM 1.05138646987689 0.138533590173284 no 485 0.14654056370069 849 4894980 YPL153C RAD53 SGTC_182 3448-4371 550.524 µM 1.05138497256469 0.138533927757115 no 486 0.146540907405238 806 3491403 SGTC_1148 3909-7663 27.7 µM 1.04553733662518 0.139856612217626 no 487 0.147887346875069 781 4084526 SGTC_325 2810-4341 181 µM 1.04281677259972 0.140474896489247 no 488 0.14851658082942 769 774970 SGTC_1218 1348-1416 30.7 µM 1.03877874577245 0.1413960082988 no 489 0.14945382419609 744 6787668 SGTC_1923 st058458 19.1 µM 1.03736367195564 0.141719766352572 no 490 0.149783201044783 818 3534982 SGTC_1113 artemisinin 1.17947 µM 1.03595427482264 0.142042724356003 no 491 0.150111737526136 813 2240 An anti-malaria and mitochondrial poison. SGTC_2285 7945142 200 µM 1.03479927863642 0.142307758492753 no 492 0.150381329944509 722 2970608 SGTC_722 3534-0461 190 µM 1.03036193017594 0.143329096476053 no 493 0.15142006862854 756 658262 SGTC_644 1498-1197 63.3 µM 1.02952956454693 0.143521230827139 no 494 0.151615447215813 805 6741615 SGTC_3017 9080681 49.47 µM 1.02872127834222 0.14370797326008 no 495 0.151805334017006 756 16451914 SGTC_250 brefeldin a 552.239 µM 1.02868154760053 0.143717156679344 no 496 0.151814671842478 675 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2249 haloperidol 116.36 µM 1.02803930695607 0.143865660019982 no 497 0.151965669141993 884 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1301 naphtanilide LB 4.81 µM 1.02796219891188 0.143883496435032 no 498 0.151983804731928 837 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_759 3486-0358 89.3 µM 1.02741164890571 0.144010891456163 no 499 0.152113334283229 844 875103 SGTC_593 1203-0218 61.7 µM 1.02592204305944 0.144355961423527 no 500 0.152464165729023 813 3666956 SGTC_838 0109-0203 71.4 µM 1.02423526054497 0.144747380010375 no 501 0.152862083949249 794 759422 SGTC_686 1319-0111 510 µM 1.02273349927412 0.145096465278396 no 502 0.153216933965987 814 4562600 SGTC_162 k030-0015 37.8 µM 1.02042933665262 0.14563316998297 no 503 0.153762443226467 827 1809920 YMR134W ERG29 SGTC_2524 avocatin b 10.57 µM 1.01737955399455 0.146345600834442 no 504 0.154486452321603 731 6710748 SGTC_27 0485-0001 32.618 µM 1.01678881979272 0.14648386673488 no 505 0.15462695092083 719 2054479 SGTC_2125 5246583 200 µM 1.0140059723304 0.14713639292474 no 506 0.155289951252438 881 835267 SGTC_1273 0849-0096 14.1 µM 1.01307687850202 0.147354681482406 no 507 0.155511720649562 781 5286025 SGTC_1430 4049-0248 69.1 µM 1.01253301884992 0.147482560767957 no 508 0.155641633748366 879 22774488 SGTC_1310 1188-0297 994 nM 1.01119022006211 0.147798615253669 no 509 0.155962697871107 797 1588352 SGTC_616 4092-0450 108 µM 1.01077535643424 0.147896353320535 no 510 0.156061980262361 829 787165 SGTC_802 4112-3352 742 µM 1.00999359012473 0.148080647863404 no 511 0.156249180518883 845 704594 SGTC_2017 5132927 60.65 µM 1.00925267505533 0.148255453878571 no 512 0.156426735095372 778 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2878 9043973 25.97 µM 1.00895058744985 0.148326765793625 no 513 0.156499166174387 760 6465167 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.00878395376017 0.148366111774765 no 514 0.156539129125799 857 1273210 SGTC_1281 0884-0031 11.8 µM 1.00866547997213 0.148394090360166 no 515 0.15656754620736 810 1548255 SGTC_1117 retinoic acid 1.10837 µM 1.00790756874589 0.148573160989024 no 516 0.156749418885681 852 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2915 7971052 15.16 µM 1.0070946682425 0.148765384374502 no 517 0.156944641581215 627 5741558 SGTC_535 2293-4129 48.2 µM 1.00637288941061 0.148936199830946 no 518 0.157118114895833 878 396118 YIL048W NEO1 SGTC_404 fumagillin 50 µM 1.00363292166863 0.14958583041064 no 519 0.157777790018978 819 12015870 A methionine aminopeptidase binder. SGTC_299 1273-0059 1.44 µM 1.0015967209441 0.150069824807789 no 520 0.158269202661959 762 2848077 SGTC_232 clozapine 119 µM 1.00077629833739 0.150265129773299 no 521 0.15846748537082 789 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_775 4577-0580 57.3 µM 1.00022843129123 0.150395646056675 no 522 0.158599986559535 797 2006902 SGTC_1287 0971-0001 34.6 µM 0.998523706322252 0.150802239224142 no 523 0.159012737462873 832 4665869 SGTC_743 1275-0778 158 µM 0.990174935609787 0.152804060728601 no 524 0.161044310637852 849 2849257 YMR203W TOM40 SGTC_857 0438-0306 1.35 µM 0.990167527127616 0.152805844883183 no 525 0.161046120892485 810 4686136 SGTC_1451 4152-0210 104 µM 0.990102081109285 0.152821606581266 no 526 0.161062113133321 842 659563 SGTC_2442 5158906 48.48 µM 0.987738466072315 0.153391570653171 no 527 0.16164037529297 828 1893835 SGTC_810 3825-7150 143 µM 0.987347842036066 0.1534859014713 no 528 0.161736072228791 875 22330411 YGL099W LSG1 SGTC_817 1391-0715 46 µM 0.984349768376049 0.154211177619048 no 529 0.162471783517494 779 1353946 SGTC_3170 9103054 49.47 µM 0.982808945059838 0.154584804833007 no 530 0.162850739274281 758 16432970 SGTC_3154 9100113 49.47 µM 0.980917742592586 0.155044211035473 no 531 0.16331665360626 805 25237525 SGTC_2313 7726885 200 µM 0.979825082389175 0.155310047820898 no 532 0.163586234354301 783 726423 SGTC_319 1348-1596 45.5 µM 0.979736301136004 0.155331660901375 no 533 0.163608151119531 854 5380505 SGTC_1228 0124-0032 52.5 µM 0.978481362492319 0.155637377917378 no 534 0.163918152382849 866 X1228 SGTC_1234 0326-0494 15.5 µM 0.977123939342415 0.155968507792933 no 535 0.164253898707974 829 1547813 SGTC_1092 toremifene 6.32 µM 0.976226465388746 0.156187692453545 no 536 0.164476125476142 888 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_958 1222-0007 33 µM 0.975870076027779 0.1562747875497 no 537 0.164564426367034 873 7312461 SGTC_1754 st042065 16.137 µM 0.974074289069545 0.156714131976555 no 538 0.165009827234962 910 1126236 YIL048W NEO1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.967360490719191 0.158363876346123 no 539 0.16668192685925 766 2374 Ca(2+)-ATPase inhibitor. SGTC_608 k048-0125 159 µM 0.966613789974671 0.158548060496793 no 540 0.166868569148945 856 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1992 st073643 23.3 µM 0.964598709010415 0.159045809150751 no 541 0.167372923145265 817 3161292 SGTC_34 0469-0683 81.75 µM 0.96439073117128 0.159097240342543 no 542 0.167425033723512 843 3690923 SGTC_3062 9077494 49.47 µM 0.963504791043273 0.159316448021545 no 543 0.167647130494916 802 16459633 SGTC_2880 9042983 58.44 µM 0.962651311739612 0.159527810887957 no 544 0.167861269014033 821 6464714 SGTC_1734 st037168 69.4 µM 0.962416801334967 0.159585919167521 no 545 0.167920138654631 811 708907 SGTC_1701 st028638 40.4 µM 0.962043951061488 0.159678334578999 no 546 0.168013763402178 860 3490878 SGTC_3045 9092950 49.47 µM 0.961225669620472 0.159881278187661 no 547 0.168219356106434 883 44120432 SGTC_1418 3966-3099 2.4 µM 0.960927412431754 0.159955291482778 no 548 0.168294333269246 850 740335 SGTC_1159 4092-0538 61.2 µM 0.959787994214799 0.160238247352756 no 549 0.168580962951982 887 717301 SGTC_2002 4023503 131 µM 0.957834039600189 0.160724241142649 no 550 0.169073225779588 960 4736863 YCR052W RSC6 SGTC_1626 st003712 1.76 µM 0.955727361286813 0.16124929805009 no 551 0.16960499761883 783 24207035 SGTC_1574 spiramycin 23.7 µM 0.953786615603502 0.161733987904629 no 552 0.170095832878007 841 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2253 7938677 135.83 µM 0.953773288765723 0.161737319483207 no 553 0.170099206521273 848 2301972 SGTC_975 1335-0046 28.5 µM 0.953028990172689 0.161923457823432 no 554 0.170287691230864 848 16486740 SGTC_2661 dactinomycin 12.96 µM 0.952009473159338 0.16217865073364 no 555 0.170546088782622 883 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_780 0109-0199 192 µM 0.951690527229261 0.162258539089559 no 556 0.170626977459124 901 610414 SGTC_965 1291-5240 308 µM 0.951338603973608 0.162346717204983 no 557 0.170716258094042 861 2834598 SGTC_544 k015-0020 52.4 µM 0.949694655399456 0.162759039102813 no 558 0.171133713120934 827 3008304 SGTC_2969 9091408 28.7 µM 0.949289739949126 0.162860701170893 no 559 0.171236635183747 803 4286311 SGTC_1469 k284-2957 126 µM 0.946895525547339 0.163462659946251 no 560 0.17184600909957 848 23884841 SGTC_1971 st069429 63.5 µM 0.94610954076852 0.163660588669915 no 561 0.172046359005659 869 1246522 YGL099W LSG1 SGTC_845 0330-0138 4.51 µM 0.944648609344222 0.164028897409953 no 562 0.172419150822751 877 9039800 SGTC_1937 st074714 47.2 µM 0.942969223832848 0.164452943423701 no 563 0.172848322516286 840 17250970 SGTC_650 1328-0195 38 µM 0.942238500428625 0.164637673252237 no 564 0.173035273310935 878 2780821 SGTC_2572 astragaloside iv 100 µM 0.942090774055499 0.164675035408635 no 565 0.17307308378278 841 45006101 An anti-inflammatory agent. SGTC_2646 retinol 96.75 µM 0.939927883281777 0.16522269101298 no 566 0.17362727683361 845 445354 A vitamin A analog and teratogen. SGTC_1606 st000094 49.2 µM 0.937059896232768 0.165950696457294 no 567 0.174363874415642 930 1242210 SGTC_2492 derrusnin 100 µM 0.936312688744498 0.166140706353015 no 568 0.174556108490105 787 1715307 Part of coumarin class of compounds. SGTC_2981 9013952 38.96 µM 0.934414310794726 0.166624083102373 no 569 0.175045109277433 786 2996344 SGTC_2784 7567673 72.73 µM 0.934274881318772 0.166659621243358 no 570 0.17508105896809 900 3471247 SGTC_2226 7298446 200 µM 0.930891881351878 0.167523387845165 no 571 0.175954747273506 843 3283010 SGTC_2352 9027995 87.8 µM 0.930800040242964 0.167546877373728 no 572 0.175978504443331 821 2997347 SGTC_2047 4141938 200 µM 0.930440116669242 0.167638952842594 no 573 0.176071627919618 818 3807862 SGTC_3181 9108277 49.47 µM 0.930222345838209 0.167694678689385 no 574 0.176127987184443 843 17097298 SGTC_749 1000-0129 128 µM 0.92959338900762 0.167855690780305 no 575 0.176290825823516 929 708470 SGTC_725 1497-0963 19 µM 0.929153714423332 0.167968305960095 no 576 0.17640471533017 910 3549977 SGTC_107 0358-0022 2.6945 µM 0.929026841420626 0.168000811364544 no 577 0.176437588068823 773 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3064 1327-0027 10 µM 0.926076902540868 0.168757739545208 no 578 0.177203008226628 735 16000455 YPR107C YTH1 SGTC_3272 9137413 49.47 µM 0.92560904553723 0.168877988549138 no 579 0.177324595409584 865 17614870 SGTC_1200 1643-0193 18.4 µM 0.923920622053029 0.169312406253818 no 580 0.177763822677478 936 5403974 SGTC_153 4077-0274 519.67 µM 0.921391744020396 0.169964406614238 no 581 0.178422968790428 843 3121976 SGTC_1073 triclabendazole 3.09 µM 0.920846067343724 0.170105304901981 no 582 0.17856539984838 932 50248 An antihelmetic and likely tubulin inhibitor. SGTC_322 k048-0136 19.3 µM 0.920667924726761 0.170151319020494 no 583 0.178611913655326 849 6823282 SGTC_1799 st045822 46.1415 µM 0.919092334357269 0.170558640148831 no 584 0.179023639228678 878 3674992 SGTC_1125 tnp00248 1.32998 µM 0.917446375497622 0.170984819107203 no 585 0.179454390372914 1011 24207736 SGTC_270 tamoxifen 5.46 µM 0.916345490951554 0.171270244872316 no 586 0.179742857648788 954 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1652 st011932 78 µM 0.91314523841118 0.17210170141612 no 587 0.180583080252015 884 1551076 SGTC_697 0508-1955 564 µM 0.911957199125237 0.172411020139338 no 588 0.18089562453412 927 6243113 SGTC_2483 5729050 27.16 µM 0.910055353569309 0.172906923661776 no 589 0.181396659185098 973 2865180 SGTC_2797 7859098 81.82 µM 0.909790485019031 0.172976059794184 no 590 0.181466506753473 884 972681 SGTC_293 4049-0273 38.5 µM 0.908010295071925 0.173441182830187 no 591 0.181936391213038 845 1380311 SGTC_1716 st033144 30.6155 µM 0.907620646441983 0.173543095227215 no 592 0.182039341105136 936 674617 SGTC_526 4469-0568 170 µM 0.906921213057272 0.17372612724314 no 593 0.182224231233896 878 2901964 SGTC_2090 5301565 104.445 µM 0.904353235977704 0.174399183852897 no 594 0.182904063272453 927 2056344 SGTC_3345 9148410 3.559 µM 0.903010907654217 0.174751661140186 no 595 0.183260052955259 909 4903596 SGTC_3072 9116419 49.47 µM 0.902979239759777 0.174759982158116 no 596 0.183268456593947 845 17170162 SGTC_2038 4100038 30.985 µM 0.902382092813633 0.174916934857696 no 597 0.183426965137665 883 3596803 SGTC_1480 1070-0044 41.2 µM 0.902175891042312 0.174971153217519 no 598 0.183481719822823 919 3124987 SGTC_2215 7188065 200 µM 0.900681755869141 0.175364337222253 no 599 0.183878775821935 897 940217 SGTC_2443 5493264 126.67 µM 0.899952000775065 0.175556576864271 no 600 0.184072897508389 920 5340055 SGTC_3230 9131665 49.47 µM 0.899199170112412 0.175755035212641 no 601 0.184273291154814 839 15943720 SGTC_402 epigallocatechin gallate 10 µM 0.898554745362634 0.175925028859342 no 602 0.184444936367396 921 65064 An antioxidant. SGTC_2550 chrysin dimethyl ether 71.87 µM 0.897065493938781 0.17631827863306 no 603 0.184841985016894 793 88881 An O-methylated flavonoid and antioxidant. SGTC_1388 3346-4487 254 µM 0.896322273704564 0.176514740284907 no 604 0.185040333185659 965 3345614 SGTC_657 3534-0529 86.7 µM 0.895109937966588 0.176835504180803 no 605 0.185364160995484 932 1049549 SGTC_189 3970-0742 2.116 µM 0.893469500002567 0.177270122965841 no 606 0.185802899217494 946 2891807 SGTC_32 0928-0142 34.1 µM 0.893375104921421 0.177295152572903 no 607 0.185828164942307 919 2244242 SGTC_1311 1190-0148 100 µM 0.893268467001068 0.177323431150666 no 608 0.185856710140546 1026 1961333 SGTC_3021 9087658 49.47 µM 0.890771724142272 0.177986339056191 no 609 0.186525823701607 924 25237042 SGTC_1704 st028805 70.8 µM 0.885024923814792 0.179518095378754 no 610 0.188071594514325 907 2876101 SGTC_1941 st076221 61.8 µM 0.884859979618181 0.179562181697053 no 611 0.188116077515026 960 2828568 SGTC_1739 st037196 92.5 µM 0.884067590672705 0.179774066426098 no 612 0.188329863561382 974 612214 SGTC_2393 9031399 185.94 µM 0.882078065159152 0.180306757283343 no 613 0.188867296547193 939 1526623 YDL150W RPC53 SGTC_2570 licareol 100 µM 0.880425604773391 0.180749951904174 no 614 0.189314395366383 862 443158 SGTC_1637 st007924 17.4 µM 0.877936819495169 0.181418738924849 no 615 0.189989003268722 891 683336 SGTC_713 1488-1073 324 µM 0.877580367412797 0.181514651491987 no 616 0.19008574367924 955 3312542 SGTC_1352 1496-0991 99 µM 0.876265878637155 0.181868622641813 no 617 0.190442754993388 938 3000039 SGTC_972 1319-0219 195 µM 0.875208483305578 0.182153675682083 no 618 0.190730239100661 897 23903702 SGTC_1889 st059080 5.18 µM 0.873037822948754 0.182739717655802 no 619 0.191321231105549 980 176925 Isolated from Daphnopsis sellowiana. SGTC_2003 4023581 200 µM 0.87194819852529 0.183034341261155 no 620 0.191618318923463 915 16641307 SGTC_2650 prasterone 100 µM 0.871864583345571 0.183056962211257 no 621 0.191641128401858 907 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_394 menadione 8.33 µM 0.871818463074415 0.183069440169923 no 622 0.191653710313779 949 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_517 1365-0151 113 µM 0.871514300728806 0.18315174536816 no 623 0.191736700462917 908 768657 SGTC_1634 st006576 41 µM 0.871004925437611 0.183289632108937 no 624 0.191875731870739 944 3915356 SGTC_2723 salbutamol 83.58 µM 0.870564032258762 0.183409033145652 no 625 0.19199612124578 875 9884233 β2-adrenoceptor agonist SGTC_2395 5646831 180.19 µM 0.869028400853691 0.18382528553544 no 626 0.192415798354967 932 6808628 SGTC_654 1124-0271 80.9 µM 0.868951675514517 0.183846098335483 no 627 0.192436781545044 957 5403748 SGTC_3004 9076122 71.4286 µM 0.868650114190179 0.183927915198624 no 628 0.192519267444362 949 44782551 SGTC_3034 9090421 49.47 µM 0.865139986001446 0.184881918432517 no 629 0.193480980052684 910 17173761 SGTC_2398 5228213 48.84 µM 0.865119204722158 0.184887575632038 no 630 0.19348668246561 1020 80771 YMR134W ERG29 SGTC_739 1486-1183 203 µM 0.864952240061765 0.184933031617627 no 631 0.193532501529268 986 4346692 SGTC_912 3474-0017 2.18 µM 0.863603652783977 0.185300437878589 no 632 0.193902828428088 975 3360550 SGTC_3080 9117754 49.47 µM 0.859557527408139 0.18640547287135 no 633 0.195016497974222 1009 9550191 SGTC_2116 5511452 16.8835 µM 0.858648942779878 0.186654176021932 no 634 0.195267113578613 949 870744 SGTC_3106 9121286 49.47 µM 0.857803029645243 0.186885908939107 no 635 0.195500618280586 924 15943471 SGTC_2069 5228469 200 µM 0.857480990738546 0.186974176368934 no 636 0.195589558008274 916 2835210 SGTC_615 k087-0205 167 µM 0.857212418503027 0.187047808876024 no 637 0.195663750257837 926 9642773 SGTC_208 k072-0098 12.366 µM 0.857144526218274 0.187066425252623 no 638 0.195682507996604 1042 5948901 SGTC_214 4373-3496 70 µM 0.855835664092745 0.187425545265496 no 639 0.196044342610051 1100 3779166 SGTC_3100 9120536 49.47 µM 0.855087849407531 0.187630918626858 no 640 0.196251257852399 865 16421196 SGTC_1481 3346-2004 36 µM 0.854894379934092 0.187684074040439 no 641 0.196304811092615 996 2770522 SGTC_1322 1348-1070 12 µM 0.854314561522838 0.187843433885989 no 642 0.196465360548715 970 6758089 SGTC_3331 9141060 1.957 µM 0.846598282044838 0.1899721582172 no 643 0.198609535912273 936 4906567 YPR165W RHO1 SGTC_1048 3161-0300 24.5 µM 0.846321974733908 0.190048658338564 no 644 0.198686576144597 1019 2165101 SGTC_2708 st078559 56 µM 0.843068159810233 0.190950953003836 no 645 0.199595162441516 896 17250902 SGTC_2220 6782180 200 µM 0.841767940328289 0.191312242170892 no 646 0.199958930230701 925 833803 SGTC_671 0560-0003 407 µM 0.841191965959015 0.191472420739206 no 647 0.200120200293583 953 3238678 SGTC_994 3910-0338 138 µM 0.840347863682619 0.191707314124168 no 648 0.200356686078739 1014 3479481 SGTC_1277 0873-0036 22 µM 0.840128893587595 0.191768277055598 no 649 0.200418060697093 1022 5965735 SGTC_1646 st011709 75.6 µM 0.839155539382164 0.192039409862002 no 650 0.200691016525012 951 5757843 SGTC_230 MPP+ 141.667 µM 0.839145822143615 0.192042117830754 no 651 0.200693742635906 939 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_377 3970-0964 33.1 µM 0.838406357527126 0.192248257992456 no 652 0.200901260043614 1054 16481235 SGTC_2127 5253358 187.912 µM 0.837649023083553 0.192459519949081 no 653 0.201113925693163 901 20612 SGTC_1392 3455-1037 33.9 µM 0.835811181473228 0.192972784232507 no 654 0.201630567558103 964 981132 SGTC_2769 toremifene 3.73 µM 0.833095059790899 0.193732859575336 no 655 0.20239555977355 967 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2821 7996764 71.43 µM 0.832907723382786 0.193785350709876 no 656 0.202448386739636 1052 2987135 SGTC_1289 0976-0073 69.1 µM 0.832850141830865 0.193801486640581 no 657 0.202464625809291 1007 3391136 SGTC_1825 st052143 62.6 µM 0.831609684781438 0.194149295583134 no 658 0.202814646864957 964 674173 SGTC_3081 9117243 49.47 µM 0.831004675366982 0.194319070658779 no 659 0.202985494078194 998 45595589 SGTC_48 0382-0018 55 µM 0.83063651233278 0.194422427174331 no 660 0.20308950083884 1003 762596 SGTC_1472 k841-0093 193 µM 0.829146905338628 0.194840954590605 no 661 0.203510642353129 1045 X1472 SGTC_1791 st048313 56.1 µM 0.829092302582197 0.19485630645731 no 662 0.203526089528666 953 1204976 SGTC_1677 st019204 53.9 µM 0.827658429333786 0.195259711106046 no 663 0.203931983996136 922 3945625 SGTC_2689 tacrolimus 100 µM 0.824277669918184 0.196212857753787 no 664 0.204890901787935 975 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1604 st002052 72.4 µM 0.824144594172516 0.196250433778163 no 665 0.204928702122513 997 6254834 YHR062C RPP1 SGTC_1435 4092-0789 56.7 µM 0.824085700239669 0.196267064796585 no 666 0.204945432342372 1026 2248285 SGTC_184 1494-0393 24.714 µM 0.822223469772125 0.196793379388438 no 667 0.205474861788088 998 3090647 SGTC_1466 k213-0079 57.5 µM 0.820347849438146 0.19732434131514 no 668 0.20600891798988 1010 3657981 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.819059066133826 0.197689679618128 no 669 0.206376357402733 1010 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1497 4476-2978 41.3 µM 0.816957538042891 0.198286287095749 no 670 0.206976347191418 1048 1528379 SGTC_54 0159-0055 9 µM 0.816922926579948 0.198296122108289 no 671 0.206986237454254 1024 3319099 SGTC_894 0960-0238 55.9 µM 0.816536077696699 0.19840606710048 no 672 0.207096798968835 1023 6741907 YDL195W SEC31 SGTC_2065 5221596 34.26 µM 0.814742750585025 0.198916222736647 no 673 0.207609788526814 985 788581 SGTC_805 3852-0218 479 µM 0.814195866760369 0.19907195435102 no 674 0.20776637646049 948 6615355 SGTC_466 geldanamycin 89.2 µM 0.814075087096343 0.199106357684228 no 675 0.207800968414306 928 5288382 HSP90 inhibitor. SGTC_1851 st056236 18.9 µM 0.810961659637315 0.199994433774335 no 676 0.208693844448018 1066 5393171 SGTC_2095 5432005 200 µM 0.81039935342253 0.200155079902307 no 677 0.208855344681459 978 783734 SGTC_1657 st012939 43.4 µM 0.809912764414709 0.200294156840063 no 678 0.208995157551205 1004 24207257 SGTC_3035 9091303 49.47 µM 0.809107250342699 0.200524516563912 no 679 0.209226729102774 1034 25237002 SGTC_3231 9132313 49.47 µM 0.808124922949364 0.200805656318672 no 680 0.2095093357841 1020 4905967 SGTC_1798 st045719 60.953 µM 0.807861308710502 0.200881142324153 no 681 0.209585213409185 990 3980186 SGTC_890 0929-0006 47.2 µM 0.80761584788325 0.200951445401961 no 682 0.20965588036176 994 1378169 SGTC_2625 euphol 100 µM 0.80704538347659 0.201114890612906 no 683 0.209820168344172 1029 6708538 A triterpene alcohol. SGTC_861 0443-0273 110 µM 0.805793819749936 0.201473758549805 no 684 0.210180871085114 1039 6149169 SGTC_2293 7624732 200 µM 0.805653149825696 0.201514117606541 no 685 0.210221435146325 1028 894453 SGTC_183 3914-0051 30.55 µM 0.805648100487166 0.20151556638253 no 686 0.210222891276355 1035 1596232 SGTC_1788 fluconazole 20 µM 0.804932692747774 0.20172089705202 no 687 0.21042926068174 957 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2211 7117706 200 µM 0.803132695551987 0.202238071951432 no 688 0.210949020864619 999 822771 SGTC_3291 9121177 71.43 µM 0.802454783508451 0.2024330549635 no 689 0.211144967061551 940 17015612 SGTC_1913 st060213 96.1 µM 0.799271301595602 0.203350199481045 no 690 0.212066557879573 1076 688959 SGTC_2795 7780010 54.55 µM 0.797626478185064 0.203825034400456 no 691 0.212543640373545 984 953673 SGTC_1244 0416-0015 52.5 µM 0.796585350086398 0.204125933135806 no 692 0.212845944226046 1023 96201 SGTC_923 1900-2434 73.3 µM 0.796333426531683 0.204198781857089 no 693 0.21291913090145 1012 5910570 SGTC_1756 st041558 35.5 µM 0.795260291862557 0.204509273562031 no 694 0.213231053280109 1132 3955792 SGTC_1729 st035615 45.989 µM 0.794453752282869 0.204742815727507 no 695 0.213465661174545 986 17385451 SGTC_2248 tofa 1.1 µM 0.793147356447443 0.20512143300678 no 696 0.213845987309404 993 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3032 9089427 49.47 µM 0.792679273185371 0.205257193238188 no 697 0.213982354597254 1039 17173707 SGTC_3186 9110464 49.47 µM 0.790065802169052 0.20601617017656 no 698 0.214744670180998 1031 17018021 SGTC_1101 ebselen 5.29 µM 0.787839698822645 0.206663962584535 no 699 0.215395238374759 1139 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2061 5245884 80.95 µM 0.787330530653466 0.206812299003784 no 700 0.215544200884158 1081 573863 SGTC_139 0099-0334 718.624 µM 0.787114748428482 0.206875182043458 no 701 0.21560734826706 1136 97690 SGTC_261 5-fluorouridine 15.376 µM 0.787050710958158 0.206893845956254 no 702 0.215626090515322 1028 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1751 st044839 27.194 µM 0.785955482577473 0.20721320780436 no 703 0.215946784091047 1079 5291326 SGTC_3102 9121669 49.47 µM 0.785689169340652 0.20729090714675 no 704 0.216024804956731 1062 41905072 SGTC_1213 1315-0166 115 µM 0.783801608225336 0.207842114112751 no 705 0.216578265025682 957 768401 SGTC_1192 1488-0095 21.4 µM 0.783256578383856 0.20800143503285 no 706 0.216738228113929 1013 915875 SGTC_1873 rapamycin 2 nM 0.782394866809487 0.208253474128446 no 707 0.21699127480288 1061 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1203 3992-3522 103 µM 0.781971623022919 0.208377333224719 no 708 0.217115625340067 1115 5322312 SGTC_888 0916-0002 6.97 µM 0.781929223703559 0.208389743459101 no 709 0.217128084680083 1084 2802138 YIL048W NEO1 SGTC_3306 9127676 59.7925 µM 0.781277275807517 0.20858062277548 no 710 0.217319716185361 1059 41905287 SGTC_3065 9113888 49.47 µM 0.781204613745731 0.208601903380645 no 711 0.217341080290035 1029 16648368 SGTC_206 4546-0025 72.014 µM 0.779098571906779 0.209219257793873 no 712 0.217960825659716 1115 6620745 YIL048W NEO1 SGTC_2544 sphondin 68.51 µM 0.778919278957393 0.209271864451847 no 713 0.218013633257097 1058 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3298 9116858 71.43 µM 0.77850650780294 0.209393005949878 no 714 0.218135235803824 1074 2506942 SGTC_1896 st058441 89 µM 0.778343986287549 0.209440714642989 no 715 0.218183125430992 979 688759 SGTC_3304 9125678 46.087 µM 0.777988665037632 0.209545042568112 no 716 0.218287847759733 1019 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_39 0986-0283 58.349 µM 0.777306246749227 0.209745497057021 no 717 0.218489055211115 1112 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3286 9117135 37.221 µM 0.776957453977247 0.209847995451053 no 718 0.21859193615938 1068 3438150 SGTC_1 0258-0098 57.368 µM 0.77623966848853 0.210059020936801 no 719 0.218803744022523 964 6790032 YDR047W HEM12 SGTC_2846 9008642 19.48 µM 0.775814425910936 0.210184099001917 no 720 0.218929282493307 1031 2992898 SGTC_2381 9035592 200 µM 0.771951981775945 0.211322174585072 no 721 0.220071434022006 1003 4749657 SGTC_335 4077-0256 27.6 µM 0.771016096442185 0.21159847707904 no 722 0.220348695383056 1134 3121989 SGTC_108 0509-0257 621.132 µM 0.76677960021534 0.212851865391768 no 723 0.221606283604224 1080 536624 SGTC_113 0099-0221 2.5 µM 0.76451831751401 0.213522647031823 no 724 0.222279212527808 1060 89219 SGTC_2891 9063876 19.48 µM 0.763980736200202 0.213682294953129 no 725 0.222439361237988 1039 6472478 SGTC_1680 diphenhydramine 100 µM 0.763710803155711 0.213762484389984 no 726 0.222519800728449 1032 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2251 lansoprazole 556 µM 0.762726815746277 0.214054947441859 no 727 0.222813167344472 920 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2721 ifenprodil 61.44 µM 0.762424330188044 0.214144899688507 no 728 0.222903394843503 1084 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_740 k014-0057 261 µM 0.760858781181772 0.214610809337018 no 729 0.223370710212655 1103 4012779 SGTC_1559 coumarin 343 70.1 µM 0.760619609788569 0.214682038934607 no 730 0.223442151776404 1070 108770 A hepatotoxic, DNA x-linker. SGTC_2324 6149169 200 µM 0.758530178985807 0.215304893522448 no 731 0.224066826670178 1055 2888231 SGTC_2924 9010168 62.78 µM 0.75743846088457 0.215630748861243 no 732 0.224393610638409 1127 2993929 SGTC_674 0498-0004 451 µM 0.755700559769543 0.216150065993206 no 733 0.224914374193306 1073 4231473 SGTC_1345 1488-0192 31.4 µM 0.755206074209261 0.216297959716627 no 734 0.225062672310827 1136 658348 SGTC_2166 5933061 31.504 µM 0.754482208488679 0.216514563451006 no 735 0.225279862306142 1299 2877375 SGTC_2357 9067248 200 µM 0.75197366364378 0.217266170555441 no 736 0.22603344843189 1088 9150235 SGTC_3109 9122853 49.47 µM 0.750038101443796 0.217847129832084 no 737 0.226615878769861 1152 1234709 SGTC_1169 aniline yellow 25.8 µM 0.749818226231712 0.217913182031741 no 738 0.226682094993837 1095 6051 A DNA damaging agent. SGTC_3139 9095020 49.47 µM 0.749369334899126 0.218048068281022 no 739 0.226817314155611 942 25236292 SGTC_685 1278-0033 54.9 µM 0.749325911776886 0.218061118940592 no 740 0.226830396879938 1124 3590572 SGTC_1504 k297-0033 30 µM 0.748073066785327 0.218437850754339 no 741 0.227208043243966 1030 4388117 SGTC_2965 9082772 38.63 µM 0.745982115492294 0.219067436144519 no 742 0.22783910938779 1145 16459634 SGTC_3130 9127414 49.47 µM 0.745798253460029 0.219122846866241 no 743 0.227894647585677 1159 1494646 SGTC_401 neomycin 50 µM 0.743319131182482 0.219870769405456 no 744 0.228644245827691 1083 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_105 0111-0055 734.78 µM 0.743209066374156 0.219904008618868 no 745 0.228677557573614 1035 5179370 SGTC_1499 4480-0877 67.3 µM 0.742688393628385 0.220061289173688 no 746 0.228835179102281 1066 2861909 SGTC_1996 st072960 66.8 µM 0.740871946715883 0.220610491556832 no 747 0.229385543236078 1145 1719405 SGTC_3073 9114972 49.47 µM 0.74080359500519 0.220631173001904 no 748 0.229406267553316 1030 41905075 SGTC_882 0843-0131 351 µM 0.739600929409405 0.220995249901494 no 749 0.229771088781263 1166 5425421 SGTC_2037 5169046 200 µM 0.738625482561677 0.221290794396368 no 750 0.230067223047772 1115 5718022 SGTC_269 exalamide 29 µM 0.738304585333744 0.221388070418732 no 751 0.230164690360852 1073 3316 A derivative of salicylamide. SGTC_1373 2887-0003 58.5 µM 0.738127587931024 0.221441735451226 no 752 0.230218460325292 1103 776948 SGTC_3250 9135583 49.47 µM 0.737880009726679 0.221516812827365 no 753 0.230293683786868 1110 7699353 SGTC_365 0121-0052 13.6 µM 0.73784890943595 0.22152624492937 no 754 0.230303134182947 1133 3101739 SGTC_217 ketoconazole 989 nM 0.737476008594068 0.221639356243527 no 755 0.230416463858884 1088 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1035 k081-0041 55.2 µM 0.736759011912133 0.221856934215277 no 756 0.230634456554948 1166 731709 SGTC_873 0591-4978 488 µM 0.735014613758871 0.222386793928321 no 757 0.231165297047433 1189 3305145 SGTC_918 glabranin 770.725 nM 0.734086096646695 0.222669124455205 no 758 0.231448133308849 1142 124049 Also referred to as licorice root. SGTC_1853 st056710 91.2 µM 0.733855515573601 0.222739267985201 no 759 0.231518400670691 1191 269167 SGTC_2807 7945238 51.95 µM 0.731383836375581 0.223491951560417 no 760 0.232272367662758 1144 17148797 SGTC_76 0433-0009 400.328 µM 0.730829010330955 0.223661107569766 no 761 0.232441800700501 1039 2841569 SGTC_440 fluspirilene 35.1 µM 0.730542516539298 0.223748482623214 no 762 0.232529317212933 1154 3396 An atypical antipsychotic. SGTC_2546 rhodinyl acetate 100 µM 0.72979272529484 0.223977246243499 no 763 0.232758445924661 1135 6708682 SGTC_234 nsc-17383 10.7 µM 0.729775689071085 0.223982445591434 no 764 0.232763653481758 1173 408974 SGTC_2437 5741531 144.16 µM 0.728687972716021 0.224314551686415 no 765 0.233096275778587 1190 2262990 SGTC_2817 7995342 71.43 µM 0.728448236751031 0.224387786449503 no 766 0.233169622213227 1118 18879975 SGTC_134 0269-0018 6.916 µM 0.727532553496348 0.224667635089321 no 767 0.233449890400296 1065 4378915 SGTC_1309 pyrazolanthrone 13.4 µM 0.727081217943922 0.224805643841252 no 768 0.233588101868607 1165 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2619 obliquin 87.91 µM 0.727073871784574 0.224807890537034 no 769 0.233590351841633 1148 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3328 9140624 29.0385 µM 0.726831446197587 0.22488203935186 no 770 0.23366460840631 1154 4904392 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.725947956721116 0.225152382656785 no 771 0.233935337815707 1146 4330530 SGTC_874 0599-0792 117 µM 0.725750117008911 0.225212945827262 no 772 0.233995986031835 1185 765305 SGTC_152 4469-0003 551.229 µM 0.725505973970333 0.225287696201927 no 773 0.234070840642869 1141 697280 SGTC_2898 9056270 58.44 µM 0.725446647984395 0.225305862428197 no 774 0.234089032079149 1084 19154699 SGTC_617 3770-0098 35 µM 0.723072417064312 0.226033556886162 no 775 0.234817697201579 1117 5962639 SGTC_3063 1327-0034 4 µM 0.722173405845951 0.226309447442155 no 776 0.235093935813379 1083 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3206 9114350 49.47 µM 0.721895117434695 0.226394887745776 no 777 0.235179481686024 1092 17087243 SGTC_922 1866-0035 480 µM 0.721292136046611 0.22658007800066 no 778 0.23536489715942 1166 3156169 SGTC_49 0717-0965 32.132 µM 0.718927954860398 0.227306999905895 no 779 0.236092655566996 1260 5889349 YGL099W LSG1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.718483876986141 0.227443688315515 no 780 0.236229492822759 1132 442882 SGTC_585 0kpi-0023 191 µM 0.718314745691241 0.227495759572374 no 781 0.236281620080186 1110 64601 SGTC_2413 inermin 26.06 µM 0.718035704788377 0.227581683898023 no 782 0.236367635967421 1173 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2685 mycophenolic acid 18.85 µM 0.716415494164949 0.22808095199377 no 783 0.236867415250763 1135 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2678 equilin 100 µM 0.716411184558153 0.228082280820473 no 784 0.23686874539063 1188 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_225 nsc-122657 1.016 µM 0.715169778024762 0.228465238055193 no 785 0.237252070602415 1083 275685 SGTC_1187 1391-0724 117 µM 0.713995812603182 0.228827722719955 no 786 0.237614884382262 1190 6997986 SGTC_83 0170-0301 39.027 µM 0.712802641262257 0.229196468141046 no 787 0.237983945493285 1117 3089716 SGTC_3133 9127736 49.47 µM 0.712783606803948 0.22920235337279 no 788 0.237989835607447 1181 27243420 SGTC_1957 st077035 62.4 µM 0.71221702768502 0.229377571804209 no 789 0.238165197157433 1222 705593 SGTC_3193 9111931 49.47 µM 0.70985076829217 0.230110164571049 no 790 0.238898341367039 1205 17087244 SGTC_1753 st043925 64 µM 0.709721340904065 0.230150272952087 no 791 0.238938477755232 1190 670181 SGTC_1700 st030840 7.9285 µM 0.707748377990078 0.230762160358069 no 792 0.239550764398772 1181 5499307 SGTC_2144 5628481 200 µM 0.706120127159506 0.23126782367219 no 793 0.240056718016406 1174 2818399 SGTC_619 1652-1634 108 µM 0.705345839016957 0.231508500302196 no 794 0.240297520256006 1141 5400454 SGTC_1226 3909-7979 35.4 µM 0.704438941121691 0.231790574285302 no 795 0.240579731160141 1189 6615510 SGTC_2916 7875993 68.79 µM 0.704280675322086 0.231839819578617 no 796 0.240628999219708 1158 1299250 SGTC_2640 pentamidine 10.38 µM 0.703115562699649 0.232202530237031 no 797 0.240991867153692 1206 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2803 7707263 71.43 µM 0.701834465891984 0.232601712125829 no 798 0.241391200982312 1166 2199229 SGTC_1396 3511-0007 98.6 µM 0.701711654897792 0.232639999305432 no 799 0.241429501572025 1140 X1396 SGTC_1104 tacrolimus 29.8 µM 0.701124033083325 0.232823242958066 no 800 0.241612806590299 1235 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1939 st074455 53.6 µM 0.700793611014517 0.23292631680315 no 801 0.241715912907634 1197 1644229 SGTC_511 blebbistatin 171 µM 0.700773301311323 0.23293265316074 no 802 0.241722251213393 1202 3476986 A myosin inhibitor. SGTC_2564 betulinic acid 100 µM 0.699554432936257 0.233313099147227 no 803 0.242102803986078 1227 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_445 e6 berbamine 66 µM 0.699260155609404 0.233405003721653 no 804 0.242194731354783 1232 6610268 A calcium/calmodulin antagonist. SGTC_735 3076-0345 636 µM 0.696823554617795 0.234166739944408 no 805 0.242956611638298 1221 2888990 SGTC_2629 bisabolol 100 µM 0.696767271124542 0.234184351678983 no 806 0.242974225758111 1188 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2277 7947813 106.88 µM 0.696208675278636 0.234359182319158 no 807 0.243149077762787 1230 1246798 SGTC_3238 9133470 49.47 µM 0.695469977350621 0.234590492610275 no 808 0.243380409865159 1194 3534688 SGTC_1728 st035614 33.7865 µM 0.695154117410836 0.234689437132293 no 809 0.24347936147388 1172 15945546 SGTC_1239 0337-0584 35.4 µM 0.693206932143321 0.235299910844867 no 810 0.244089849231721 1237 914301 YML130C ERO1 SGTC_604 1000-0114 314 µM 0.693145117345393 0.235319305118521 no 811 0.244109243115564 1225 1572745 SGTC_2941 9056145 11.23 µM 0.69247341259017 0.235530108074544 no 812 0.244320038518735 1116 2119517 SGTC_1446 4239-0190 62 µM 0.691793805142481 0.235743497147329 no 813 0.244533413765837 1216 1340085 SGTC_485 niflumic acid 177 µM 0.687827053834181 0.236991136951297 no 814 0.245780848660048 1200 4488 A COX2 inhibitor. SGTC_3261 9137475 49.47 µM 0.68748998366751 0.237097320758158 no 815 0.24588700527078 1084 17027690 SGTC_1145 3546-0597 10.2 µM 0.687088944392522 0.23722369015333 no 816 0.246013340310672 1179 875334 SGTC_370 0180-0345 38.7 µM 0.686421244216157 0.237434167725343 no 817 0.246223755866401 1157 3989527 SGTC_465 cgp-37157 41 µM 0.685903338407041 0.237597496543939 no 818 0.246387032435502 1135 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_23 0213-0011 39.996 µM 0.685348721217253 0.237772471150842 no 819 0.246561947071612 1226 627608 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.684828202439155 0.237936752419456 no 820 0.246726168275793 1287 6728940 SGTC_1124 fisetin 1.16336 µM 0.683842519276295 0.238248014948406 no 821 0.247037307030511 1194 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1111 tnp00062 510.699 nM 0.683400158910962 0.238387777558574 no 822 0.247177009822393 1255 676306 SGTC_186 3455-3465 67.277 µM 0.680883352973782 0.239183809625771 no 823 0.247972651180679 1170 755278 SGTC_1030 k029-0042 36.7 µM 0.677683403196761 0.24019800493419 no 824 0.248986225889766 1226 6080581 SGTC_71 0417-1750 47.813 µM 0.676359221533986 0.240618376991983 no 825 0.249406300539582 1206 6811472 SGTC_2833 9001315 45.46 µM 0.67488362945277 0.241087286913251 no 826 0.249874851027739 1218 2989378 SGTC_426 0988-0037 14.6 µM 0.674746917423704 0.241130756049987 no 827 0.249918285367879 1246 5383008 SGTC_907 3448-6986 75.5 µM 0.674490759476595 0.241212215838023 no 828 0.249999679274407 1275 590582 SGTC_877 0771-0151 33.1 µM 0.674153645945992 0.241319442785563 no 829 0.250106818161968 1228 6166523 SGTC_1640 st009078 66.4 µM 0.671054562343756 0.242306392163715 no 830 0.251092885692646 1245 690618 SGTC_3167 9103034 49.47 µM 0.670272844973748 0.24255568673999 no 831 0.251341937218668 1241 5127859 SGTC_1432 4049-0298 68.4 µM 0.668963492063082 0.24297355859034 no 832 0.251759383352172 1249 741646 SGTC_1872 amphotericin b 148 nM 0.668166079401718 0.243228238568601 no 833 0.252013792637292 1239 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_886 0866-0150 153 µM 0.667387534950346 0.243477031523838 no 834 0.252262312956365 1268 271463 SGTC_90 0870-0863 4.608 µM 0.66692144165889 0.243626042831508 no 835 0.252411157096111 1233 1738164 SGTC_1116 jasmonic acid  1.58368 µM 0.665766605669459 0.243995459148029 no 836 0.2527801464784 1286 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2098 5376439 882.5 nM 0.663777203714168 0.244632549771644 no 837 0.253416459032383 1291 2844116 SGTC_2117 5521686 200 µM 0.663122593871108 0.244842379238628 no 838 0.253626020683066 1239 803312 SGTC_2767 sibutramine 71.45 µM 0.6623111134178 0.245102626620481 no 839 0.253885927959135 1307 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1334 1486-0610 236 µM 0.661463942285789 0.245374478907878 no 840 0.25415741560073 1249 3742339 SGTC_3155 9099265 49.47 µM 0.660524137357525 0.245676246338262 no 841 0.254458767058185 1216 25236499 SGTC_626 0214-0009 33 µM 0.659749891272468 0.245925003160742 no 842 0.25470717213211 1288 3437874 SGTC_1365 1672-3266 55.4 µM 0.658343022171487 0.246377360586926 no 843 0.255158869458091 1248 6415873 SGTC_1063 disulfiram 1.84 µM 0.65688210841699 0.246847566836561 no 844 0.255628361642314 1263 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.656599405265925 0.246938612443274 no 845 0.255719265702347 1233 61125 An anti-inflammatory. SGTC_897 1000-0139 31.4 µM 0.655502205927723 0.247292139744077 no 846 0.256072233301054 1249 6151020 SGTC_1355 1499-0035 1.68 µM 0.652423000245167 0.248285730507414 no 847 0.257064165388795 1270 1548538 SGTC_321 4534-3890 65.3 µM 0.652141923317362 0.248376533635967 no 848 0.257154810649649 1284 699746 SGTC_80 0159-0065 512.242 µM 0.651918211773615 0.248448817275636 no 849 0.257226967868383 1212 1548079 SGTC_1163 k060-0048 49.9 µM 0.648239943930363 0.249638911530447 no 850 0.258414885261567 1274 6809982 SGTC_1852 st056254 31.4 µM 0.647536461257101 0.249866866014898 no 851 0.25864240230237 1215 442583 SGTC_2004 4023728 41.89 µM 0.645133145264788 0.250646462348937 no 852 0.259420453021624 1248 360084 YDR527W RBA50 SGTC_3292 9120825 59.784 µM 0.643273635584478 0.251250539728806 no 853 0.260023280166838 1281 24824900 SGTC_2583 asiatic acid 100 µM 0.642317380278723 0.251561486791661 no 854 0.260333565823274 1292 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_379 3970-0972 5.9 µM 0.642086693206504 0.251636530102717 no 855 0.260408447697674 1285 2898042 YBL034C STU1 SGTC_534 k292-0788 63.4 µM 0.641906800666901 0.251695057979445 no 856 0.260466849177259 1331 4146317 SGTC_2255 7941087 197.44 µM 0.640731176160572 0.252077723302888 no 857 0.260848677538143 1305 935561 SGTC_1514 1189-1591 158 µM 0.640370910133784 0.2521950511648 no 858 0.260965745117105 1345 767698 YMR146C TIF34 SGTC_842 0271-0008 11.1 µM 0.638275303660279 0.252878098054121 no 859 0.261647242640937 1337 1221709 SGTC_942 3253-1115 227 µM 0.637999769954372 0.252967978533334 no 860 0.261736914919266 1340 46497897 SGTC_180 1486-1293 102.781 µM 0.637248515345263 0.253213126940062 no 861 0.261981490357041 1341 4140536 SGTC_2662 daunorubicin 22.37 µM 0.634825178224104 0.254004757750179 no 862 0.262771220053697 1251 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_490 phenamil 164 µM 0.6346016891535 0.254077830202621 no 863 0.262844113111531 1242 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_363 0455-0021 3.06 µM 0.632947203652134 0.254619127033081 no 864 0.263384060517395 1323 4597466 SGTC_1562 morin hydrate 59.1 µM 0.632218697819064 0.254857663151337 no 865 0.263621990512291 1320 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_679 0422-0091 41.4 µM 0.630538138773117 0.255408377763054 no 866 0.264171279023595 1289 627384 YHR062C RPP1 SGTC_356 1634-0012 32.5 µM 0.6293333451583 0.255803567726298 no 867 0.264565422685931 1300 735457 SGTC_2906 7926292 26.41 µM 0.628826819074352 0.255969810960746 no 868 0.264731220060269 1277 2966319 SGTC_3147 9097027 49.47 µM 0.62879854407953 0.255979092551569 no 869 0.264740476658425 1345 25236841 SGTC_2373 9071805 200 µM 0.628507294149188 0.256074708894999 no 870 0.264835834921048 1321 10149009 SGTC_2406 ethylparaben 405.7 µM 0.624940188508382 0.257247286862069 no 871 0.266005157212578 1194 8434 A possible steroid mimic. SGTC_1550 gossypolone 36.6 µM 0.624585475307233 0.257364040472481 no 872 0.266121577492285 1298 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1292 0kpi-0043 232 µM 0.624479694443114 0.257398863501936 no 873 0.266156300781694 1287 3333905 SGTC_1350 1495-0454 146 µM 0.624180169961144 0.257497480152818 no 874 0.266254634176165 1342 1069057 SGTC_2847 9005661 71.43 µM 0.622945377141336 0.25790423546569 no 875 0.266660208700077 1226 2991449 SGTC_2620 irigenin 100 µM 0.622647679761201 0.258002350343828 no 876 0.266758035755025 1365 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2262 9014885 67.46 µM 0.622133599619587 0.258171826061899 no 877 0.266927011566397 1260 6457424 SGTC_1129 3453-1384 223 µM 0.621668142882889 0.258325321974378 no 878 0.267080051710601 1385 1084452 SGTC_659 k018-0002 107 µM 0.620884936450108 0.258583710434281 no 879 0.267337666521003 1286 6797879 YHR007C ERG11 SGTC_318 1488-0629 67.2 µM 0.620744412152988 0.258630085109525 no 880 0.267383901491247 1310 3662576 SGTC_106 0092-0003 11.579 µM 0.619839795543867 0.258928722308712 no 881 0.267681632825332 1309 1072148 SGTC_939 1165-0479 45.3 µM 0.619679716293674 0.258981587154536 no 882 0.267734336195045 1256 1377347 SGTC_384 k007-0144 5.16 µM 0.617323996943673 0.25976018899817 no 883 0.268510520863735 1330 6824886 SGTC_3253 9135987 49.47 µM 0.615058847033408 0.260509993795737 no 884 0.269257929163014 1318 4182430 SGTC_2745 rifampicin 24.3 µM 0.614461724418396 0.260707837422361 no 885 0.269455129239629 1276 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2428 5615643 7.78 µM 0.612457005698352 0.261372622588946 no 886 0.270117717787912 1341 2253075 SGTC_875 0709-0210 25.7 µM 0.611385140631642 0.261728420835742 no 887 0.27047231878307 1345 6251364 SGTC_1895 st058434 18.3 µM 0.61125394680886 0.261771986787043 no 888 0.27051573710286 1323 5393175 SGTC_3346 9158254 43.5805 µM 0.609883010335444 0.262227460481845 no 889 0.270969653859907 1301 17639500 SGTC_2160 5660466 132.927 µM 0.609880322255466 0.262228353955964 no 890 0.27097054425572 1273 2859134 SGTC_2027 5150920 200 µM 0.609534728028406 0.262343236851447 no 891 0.271085030555499 1308 786715 SGTC_667 1498-1044 59 µM 0.608881469151929 0.262560464430354 no 892 0.27130150395945 1357 6739982 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.607736527559213 0.262941412758023 no 893 0.271681116240039 1381 23847180 SGTC_2955 9076254 12.21 µM 0.6070635436489 0.263165461722755 no 894 0.271904371431879 1268 16459619 SGTC_2208 7283366 200 µM 0.605007853718977 0.263850442909297 no 895 0.272586889175196 1353 898663 SGTC_2310 7668677 200 µM 0.604858836912497 0.263900132455182 no 896 0.272636397873865 1379 2197143 SGTC_1587 estradiol valerate 56.1 µM 0.604171475091737 0.264129394487897 no 897 0.272864821745415 1323 13791 A steroid. SGTC_2231 micatex 6.853 µM 0.602812410104226 0.264582994218658 no 898 0.273316745006283 1346 20737 An antifungal of unknown mechanism. SGTC_1818 st052136 56.3 µM 0.601412971220695 0.265050482856862 no 899 0.273782480659984 1253 674169 SGTC_302 1094-0063 18.9 µM 0.601378054692834 0.265062152237847 no 900 0.273794105956758 1291 5440289 SGTC_109 0132-0036 33.701 µM 0.601308500781408 0.265085398485317 no 901 0.273817264337953 1237 67274 A color developer. SGTC_1133 3473-0247 50 µM 0.601227588614792 0.265112442181912 no 902 0.273844205735324 1303 711311 SGTC_693 4161-2696 114 µM 0.600599695822419 0.265322353694207 no 903 0.274053320307232 1416 805759 SGTC_2928 9011484 9.79 µM 0.598914014743519 0.26588631250666 no 904 0.274615112608285 1332 2994751 SGTC_3224 9130643 49.47 µM 0.597303035565302 0.266425846244561 no 905 0.275152539078878 1387 17644395 SGTC_1003 4049-0218 100 µM 0.59583222578263 0.266918919013517 no 906 0.275643656546326 1388 295161 SGTC_2130 NSC 7 2.4545 µM 0.595618121632932 0.266990733486141 no 907 0.275715183889723 1362 21448 SGTC_2674 ligustilide 100 µM 0.595243768140345 0.267116321980724 no 908 0.275840268823444 1312 5319022 A signalling regulator. SGTC_2683 piperine 63.03 µM 0.593814143112455 0.267596208320565 no 909 0.276318214243891 1318 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_307 1501-1223 22.3 µM 0.593445477587386 0.267720029788274 no 910 0.276441530603673 1330 2830329 SGTC_292 k038-0015 474 µM 0.593146945565267 0.267820317090449 no 911 0.276541407507991 1344 46368540 SGTC_3082 9117008 49.47 µM 0.592834278311964 0.267925373195849 no 912 0.276646032459758 1354 41448529 SGTC_2465 5809242 33.21 µM 0.592811118985162 0.267933155548323 no 913 0.276653782822718 1357 2731748 SGTC_768 0384-0033 77.3 µM 0.592476724670584 0.268045536545612 no 914 0.276765701099564 1325 3965305 YMR134W ERG29 SGTC_2068 5226020 147 µM 0.592174622622188 0.268147085373813 no 915 0.276866830559882 1346 1810509 SGTC_1949 st076024 69.1 µM 0.590602622959214 0.268675810924363 no 916 0.277393353502767 1319 2921930 SGTC_2985 9022375 71.43 µM 0.589970421608581 0.268888592792845 no 917 0.277605239907202 1363 4939335 SGTC_459 nigericin 15.3 µM 0.588378387290823 0.269424803036615 no 918 0.278139170620931 1391 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_944 3370-0224 231 µM 0.587975405014643 0.269560615744537 no 919 0.278274400753535 1339 4580514 SGTC_2977 9011197 71.43 µM 0.587067241475571 0.26986680988224 no 920 0.278579273743383 1417 2704722 SGTC_2206 7254556 146.969 µM 0.585806470715961 0.270292176634302 no 921 0.27900278744089 1349 4398905 SGTC_1602 st001878 87.6 µM 0.584107034671769 0.27086607297878 no 922 0.279574151119788 1388 595405 YLR310C CDC25 SGTC_1033 k072-0102 21.3 µM 0.583808812376027 0.270966844771445 no 923 0.279674474342773 1353 5965931 SGTC_2584 androsterone 48.74 µM 0.583290474687733 0.271142039881858 no 924 0.279848886863829 1384 2754130 A steroid. SGTC_816 0325-0417 81.3 µM 0.581868425343346 0.271622974114207 no 925 0.280327654948139 1339 68101 SGTC_2962 9082311 13.18 µM 0.581811127315041 0.271642361090315 no 926 0.28034695405691 1328 16459453 SGTC_3281 9140613 49.47 µM 0.580728121719759 0.272008929112744 no 927 0.280711852712713 1262 16013766 SGTC_2828 7998861 71.43 µM 0.577009216072067 0.273269547515058 no 928 0.281966614896951 1342 2988188 SGTC_2888 9058547 12.99 µM 0.576915842738508 0.27330123600431 no 929 0.281998153881423 1303 16476514 SGTC_1423 4048-0112 5.59 µM 0.575871298876639 0.273655851130177 no 930 0.282351088292548 1391 X1423 SGTC_2491 paeonol 100 µM 0.575721679245879 0.273706664551245 no 931 0.282401659730337 1327 11092 Increases levels of cortical cytochrome oxidase. SGTC_514 4466-0038 2.65 nM 0.575052310689237 0.273934050852182 no 932 0.282627959644321 1337 5722064 SGTC_176 1486-1328 72.834 µM 0.573283898207751 0.274535234190929 no 933 0.283226242947775 1353 22310231 SGTC_2385 9074692 200 µM 0.573036034861382 0.274619548933559 no 934 0.283310147751151 1340 17046906 SGTC_758 0868-0029 16 µM 0.572473560921081 0.274810930945236 no 935 0.283500596330478 1391 762687 SGTC_2711 st079103 59.1 µM 0.57226278410923 0.274882664781417 no 936 0.283571979249619 1402 54693780 SGTC_2518 prenyletin 46.28 µM 0.571627201926385 0.275099028811975 no 937 0.283787281384507 1328 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2502 avocadyne acetate 18.59 µM 0.571353074802532 0.275192372679864 no 938 0.283880165526363 1334 3952079 SGTC_3195 9113082 49.47 µM 0.571252308248516 0.275226688927528 no 939 0.283914312521056 1359 17018038 SGTC_110 0850-0284 111.64 µM 0.566937397455861 0.276698113580025 no 940 0.285378357468755 1265 3906265 SGTC_2177 5811945 192 µM 0.564532678396864 0.277519814437677 no 941 0.286195833511416 1449 5343475 SGTC_1644 st010134 20.9 µM 0.564345151550514 0.277583943102909 no 942 0.286259629342016 1368 3818134 SGTC_3324 9138759 60.749 µM 0.563007661988945 0.278041535053998 no 943 0.286714833284821 1411 45595710 SGTC_104 0074-0074 590.992 µM 0.562451264048247 0.27823200242267 no 944 0.286904299929713 1291 3943124 SGTC_344 k064-0035 6.43 µM 0.562352875402557 0.278265689658957 no 945 0.286937809759779 1351 5088750 SGTC_1171 0368-0077 21.4 µM 0.56056877015681 0.278876893223199 no 946 0.287545773081404 1370 3239779 SGTC_638 3970-0837 4.09 µM 0.557633314069773 0.279883948988268 no 947 0.288547401475276 1384 4118451 YLR208W SEC13 SGTC_3069 9117009 49.47 µM 0.55725479785856 0.280013933367795 no 948 0.288676677316696 1330 41904981 SGTC_1727 st034309 9.9045 µM 0.556013887376847 0.280440273415177 no 949 0.289100680590074 1520 870305 SGTC_933 2914-0560 114 µM 0.556013025322086 0.280440569700828 no 950 0.289100975244957 1494 463887 SGTC_443 clozapine 122 µM 0.553877307251638 0.281175074497062 no 951 0.289831408215282 1361 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1594 piperine 70.1 µM 0.552786743345688 0.281550493423031 no 952 0.290204723546182 1369 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1854 st056233 32.9 µM 0.550292735011369 0.282409945758209 no 953 0.291059303197791 1405 5393174 SGTC_1123 mangostin 811.285 nM 0.549979706358582 0.282517906639804 no 954 0.291166646406806 1416 5281650 An antioxidant. SGTC_868 0527-0199 213 µM 0.548213142498555 0.283127550983223 no 955 0.291772779477793 1422 2849450 SGTC_351 caspofungin 25 nM 0.545951822646025 0.283908856500214 no 956 0.292549527205961 1503 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_376 3970-0862 59.1 µM 0.544194317484521 0.284516801464898 no 957 0.293153880898972 1474 3135186 SGTC_2174 5790901 200 µM 0.543754263363674 0.28466911945441 no 958 0.293305292985271 1411 786020 SGTC_1914 st062367 72.6 µM 0.543136598671066 0.284882980265311 no 959 0.293517877734544 1407 978205 SGTC_3026 9090633 49.47 µM 0.542033999886338 0.285264935534541 no 960 0.29389754195493 1388 25236842 SGTC_3246 9135460 32.98 µM 0.538255966805375 0.286575544747753 no 961 0.295200173220552 1446 41446951 SGTC_1548 st061468 90.8 µM 0.536474564115978 0.287194507141219 no 962 0.295815305306839 1429 390799 SGTC_467 ro 31-8220 72.8 µM 0.535831868320353 0.287417972089055 no 963 0.296037377567975 1419 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_506 n9-isopropylolomoucine 153 µM 0.534336545819155 0.2879382128665 no 964 0.29655435593399 1525 6610355 SGTC_420 mitomycin C 81.9 mM 0.532354233824486 0.288628567765247 no 965 0.297240338225852 1403 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3189 9110682 49.47 µM 0.531722040943324 0.288848897496118 no 966 0.297459262021533 1461 17122418 SGTC_373 0844-0104 25.9 µM 0.53165469101859 0.288872374730138 no 967 0.297482589149943 1473 5375804 SGTC_1457 k015-0032 57.3 µM 0.531262919348895 0.289008958612755 no 968 0.297618298630192 1427 4302660 SGTC_2746 daunorubicin 9.88 µM 0.530244980865592 0.289363985815431 no 969 0.297971043950494 1408 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_549 1661-1316 519 µM 0.529324427724262 0.289685224195926 no 970 0.298290206411371 1518 2857282 SGTC_2690 usnic acid 100 µM 0.529255571075811 0.289709259299774 no 971 0.298314085766887 1578 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1718 roemerine 11.9335 µM 0.528837581034619 0.289855182996671 no 972 0.298459062595803 1390 235224 An aporphine alkaloid with mutagenic activity. SGTC_1394 3474-0001 65.7 µM 0.528817409235362 0.289862226006549 no 973 0.298466059849616 1395 5017666 YIL048W NEO1 SGTC_1453 4237-0541 195 µM 0.528535398984158 0.289960698656148 no 974 0.298563892220836 1446 739892 SGTC_423 5-fluorouracil 457 µM 0.528376828012837 0.290016075531108 no 975 0.298618908591851 1368 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2484 5809818 12.04 µM 0.527999393663072 0.290147904810727 no 976 0.298749878392596 1450 2870548 SGTC_2557 derrustone 83.84 µM 0.527817703678313 0.290211375022397 no 977 0.298812934164441 1405 629853 An antioxidant. SGTC_2141 5621638 7.665 µM 0.527597581379899 0.29028827960197 no 978 0.298889336027474 1527 2856238 SGTC_55 0767-0285 6.563 µM 0.527493440669499 0.290324666781653 no 979 0.298925485136534 1400 3116166 SGTC_310 1273-0058 1.06 µM 0.526035483555224 0.290834306941333 no 980 0.299431776591586 1429 2734232 SGTC_1224 0823-0416 294 µM 0.525145731671727 0.291145531929748 no 981 0.299740943516399 1511 3598164 SGTC_3084 9116877 49.47 µM 0.523953526102408 0.291562795381995 no 982 0.300155432152187 1397 27241325 SGTC_2193 5925765 200 µM 0.523558631099357 0.291701067271839 no 983 0.300292780606885 1478 877370 SGTC_303 1348-1668 34.2 µM 0.52234115120376 0.292127558268068 no 984 0.30071641104611 1456 5380509 SGTC_81 0411-0046 9.971 µM 0.521695798421998 0.292353747094717 no 985 0.300941075264742 1369 12925265 SGTC_809 3998-0021 90 µM 0.521326880925041 0.292483085064404 no 986 0.301069539103916 1429 715485 SGTC_4 0960-0234 25.671 µM 0.521242711865841 0.292512597434497 no 987 0.301098851776469 1442 6821112 SGTC_2 0422-0095 29 µM 0.521022434861542 0.292589840162687 no 988 0.301175571417422 1335 6790840 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.520775171792226 0.292676557160765 no 989 0.301261700446597 1401 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.519769489170817 0.293029380495952 no 990 0.301612123659008 1417 4174840 SGTC_2282 7944268 200 µM 0.519579357631108 0.293096106459513 no 991 0.301678394292109 1526 2970414 SGTC_612 0302-0167 22.4 µM 0.517408314491059 0.293858525213602 no 992 0.302435578402872 1542 235821 SGTC_1948 st076329 66.6 µM 0.517222348067429 0.293923874835476 no 993 0.302500476612003 1378 24208413 SGTC_2372 9071633 200 µM 0.516045218067414 0.294337680599126 no 994 0.302911413951011 1486 21321366 SGTC_2688 kanamycin b 96.69 µM 0.515499662116613 0.294529555363009 no 995 0.303101952821945 1466 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_251 melphalan 456.522 µM 0.512785529572273 0.295484986143567 no 996 0.30405067652706 1560 460612 A DNA alkylator. SGTC_3301 9125354 19.7965 µM 0.510498738683754 0.296291088525738 no 997 0.304851049011003 1439 41905162 SGTC_803 4488-1585 147 µM 0.506536564439832 0.297690151879989 no 998 0.306240013929705 1514 747204 SGTC_505 gw-5074 63.9 µM 0.505836317044017 0.297937725812655 no 999 0.306485780648984 1532 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2602 kawain 100 µM 0.505399821155063 0.298092097322089 no 1000 0.306639022224634 1445 5369129 SGTC_1819 st053448 58.6 µM 0.503922518293696 0.298614831697673 no 1001 0.30715791292486 1500 2857616 SGTC_1146 3579-1023 7 µM 0.499184981411148 0.300293984481895 no 1002 0.308824536953271 1585 X1146 SGTC_1205 4161-2785 76 µM 0.497231691081234 0.300987540875885 no 1003 0.309512837891412 1421 3498106 SGTC_2416 tofa 880 nM 0.494766326928928 0.301863949137937 no 1004 0.310382538106647 1399 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2179 6298986 200 µM 0.492160008336111 0.302791709968999 no 1005 0.311303116634988 1592 738374 SGTC_1760 st045453 10.4495 µM 0.491496233160345 0.303028195234788 no 1006 0.311537757826834 1534 3323419 YIL048W NEO1 SGTC_570 0987-0065 62.6 µM 0.490588824161463 0.303351614321003 no 1007 0.311858646208721 1449 3104428 SGTC_248 streptozotocin 5.23457 mM 0.489619519128524 0.303697264714494 no 1008 0.312201580802862 1586 5300 DNA alkylating agent. SGTC_2526 patulin 37.61 µM 0.489563502562896 0.303717245375058 no 1009 0.312221404122511 1544 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_833 3852-0053 558 µM 0.488119650114662 0.30423245828547 no 1010 0.31273254665961 1569 3123681 SGTC_748 act1.228 77.9 µM 0.48771056763069 0.30437850279318 no 1011 0.312877432727193 1427 4421505 YNR035C ARC35 SGTC_279 1273-0055 2.93 µM 0.48736932817943 0.304500350866531 no 1012 0.312998312724618 1551 2847562 SGTC_2260 7964312 200 µM 0.486748773142559 0.304721991155107 no 1013 0.313218188448098 1595 231951 SGTC_2716 st080858 38.6235 µM 0.486195587413647 0.304919629959127 no 1014 0.313414249807437 1500 5296050 SGTC_1369 1866-0067 208 µM 0.485435323031213 0.305191345428788 no 1015 0.313683790498053 1611 3531355 SGTC_1547 harmine 94.2 µM 0.484565988369818 0.305502173801667 no 1016 0.313992122393911 1502 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2271 7849410 118.62 µM 0.484442346147311 0.305546393157121 no 1017 0.314035985844602 1522 972430 SGTC_2877 9040724 71.43 µM 0.483570779786204 0.305858180247822 no 1018 0.314345258192649 1596 6463895 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.483055178277006 0.306042693636651 no 1019 0.314528279016625 1534 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1691 st019933 84.6 µM 0.481466806020788 0.306611418489132 no 1020 0.315092382991124 1546 6176082 SGTC_1138 3761-0006 1.03 µM 0.481244944486327 0.306690894272787 no 1021 0.315171210591533 1529 12061087 SGTC_2790 5423970 71.43 µM 0.479338699346279 0.30737412833745 no 1022 0.315848847711984 1622 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1540 guanosine 70.6 µM 0.477449723220682 0.308051832909582 no 1023 0.316520957075242 1509 6802 Guanosine is a purine nucleoside SGTC_3046 9092212 49.47 µM 0.477432152971212 0.308058139634647 no 1024 0.316527211527947 1544 25236637 SGTC_2701 st077767 14.721 µM 0.476498761213488 0.308393255891786 no 1025 0.316859544840319 1480 5721188 SGTC_1530 rhein 70.4 µM 0.47587914914958 0.3086158038443 no 1026 0.317080238828417 1527 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2917 7979103 53.79 µM 0.475639389155606 0.30870193804564 no 1027 0.317165654229213 1614 2980565 SGTC_185 k048-0037 25.491 µM 0.475066565743218 0.30890776847481 no 1028 0.317369764158553 1563 6827589 SGTC_718 1130-0073 349 µM 0.474519701629803 0.309104327058522 no 1029 0.317564676036267 1580 6740020 SGTC_5 0352-0601 109.883 µM 0.473627884488898 0.309424988854418 no 1030 0.317882643662421 1494 762456 SGTC_539 4859-0462 2.54 µM 0.472010012017272 0.310007081565992 no 1031 0.318459821124521 1622 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_924 2046-0044 21.3 µM 0.471706924039102 0.310116182326253 no 1032 0.31856799710796 1477 3623589 SGTC_2350 9023895 38.85 µM 0.47131703990182 0.310256551163186 no 1033 0.318707174496825 1592 2997209 SGTC_358 0075-0058 9.45 µM 0.47009005379895 0.310698479692225 no 1034 0.319145339965764 1732 1069125 SGTC_1227 3909-8010 46.6 µM 0.469993455341431 0.310733283559978 no 1035 0.319179846703937 1539 15982272 SGTC_1413 3910-0535 34.4 µM 0.469583086994531 0.31088115578896 no 1036 0.319326455254699 1596 2876951 SGTC_528 3492-0019 172 µM 0.468463016247171 0.31128491776512 no 1037 0.319726756446844 1540 2869262 SGTC_1425 4048-4433 7.33 µM 0.467378296703085 0.311676152904788 no 1038 0.320114623760482 1567 23734946 SGTC_2717 st081029 62.2815 µM 0.467296421867633 0.311705692044194 no 1039 0.320143908046157 1546 5292846 SGTC_2242 6630449 61.2675 µM 0.467064824302629 0.311789255325245 no 1040 0.320226749934357 1540 691249 YDR170C SEC7 SGTC_2009 4012297 12.05 µM 0.466261312006566 0.312079247665579 no 1041 0.320514233795742 1510 45595307 SGTC_2463 5473429 200 µM 0.464799943990528 0.312606962544969 no 1042 0.32103736394663 1525 5399405 SGTC_497 capsazepine 133 µM 0.4647465822277 0.312626239302336 no 1043 0.32105647274375 1461 2733484 A calcium channel blocker. SGTC_2073 5212005 126 µM 0.464284579538022 0.312793157646153 no 1044 0.321221935281346 1486 691789 SGTC_1970 st070122 35.8 µM 0.462861035267537 0.31330771553571 no 1045 0.321731989245711 1582 102928 SGTC_1555 citronellol 128 µM 0.462721034235551 0.313358340317061 no 1046 0.321782169594373 1635 8842 A terpine precursor. SGTC_324 1315-0088 19.6 µM 0.461272646683637 0.313882287735238 no 1047 0.322301503500774 1555 6787421 SGTC_19 0279-0214 38.434 µM 0.458070087167199 0.315042130604331 no 1048 0.323451044332568 1568 3566274 YBR002C RER2 SGTC_2921 7974240 10.71 µM 0.457513017588732 0.315244066364437 no 1049 0.323651173911706 1599 2979074 YDR527W RBA50 SGTC_1784 st039334 36.3 µM 0.456078384899091 0.315764369742894 no 1050 0.324166806447892 1637 3496984 SGTC_715 0868-0130 184 µM 0.455290233392051 0.316050367019627 no 1051 0.324450225822749 1696 2876258 SGTC_1128 3448-9350 235 µM 0.455171301605824 0.316093533474672 no 1052 0.324493002543386 1534 619386 SGTC_2060 5238662 140 µM 0.454676612038019 0.316273108628691 no 1053 0.324670954567329 1533 790130 SGTC_804 1595-0054 20.9 µM 0.454007898503258 0.316515924367349 no 1054 0.324911570922735 1524 761523 Stimulates phospholipase C. SGTC_99 0109-0120 622.8 µM 0.45328211314792 0.316779552906052 no 1055 0.325172805527134 1634 759414 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.453132943615404 0.316833747603176 no 1056 0.325226507320417 1629 688798 SGTC_1307 1187-1599 12.2 µM 0.452071960200664 0.31721932622775 no 1057 0.325608571439885 1526 1538471 SGTC_280 3448-3607 3.04 µM 0.45193709212689 0.317268353706471 no 1058 0.325657151078748 1585 626179 SGTC_2830 7992007 71.43 µM 0.451631828837753 0.317379335395303 no 1059 0.325767118209703 1546 1952075 SGTC_73 0327-0325 16.231 µM 0.450229069864131 0.317889534187667 no 1060 0.326272638682724 1653 53298 SGTC_42 0133-0086 60.653 µM 0.449205263905552 0.318262122042082 no 1061 0.326641795288878 1461 162923 Model of phenazepam hydroxylation. SGTC_2272 7805186 180 µM 0.446533659838394 0.319235249183111 no 1062 0.327605902059934 1567 2956062 YPR165W RHO1 SGTC_3002 9075603 71.4286 µM 0.441610768044633 0.32103166579524 no 1063 0.329385445276279 1546 20105405 SGTC_2481 5478948 45.16 µM 0.440712438980069 0.321359929856627 no 1064 0.329710595109796 1544 77792 SGTC_353 1988-1175 58.3 µM 0.440661064180828 0.321378707266509 no 1065 0.329729194091373 1497 2788357 SGTC_1262 0737-0114 49.6 µM 0.439516724954766 0.32179707975057 no 1066 0.33014358301401 1616 765919 SGTC_1142 3253-1408 9.78 µM 0.438625251989828 0.322123160543749 no 1067 0.330466548313356 1590 256655 SGTC_3217 9129673 49.47 µM 0.437428508917847 0.322561117617292 no 1068 0.330900306273843 1567 17248312 SGTC_84 0443-0269 128.823 µM 0.436285082369001 0.322979793238076 no 1069 0.331314951911598 1537 6150058 SGTC_2959 9079155 11 µM 0.431006122249563 0.324915633447793 no 1070 0.333231959458813 1585 16189457 SGTC_1139 k015-0024 46.9 µM 0.430786924725506 0.324996117856185 no 1071 0.333311653818807 1636 2766652 SGTC_3216 9129716 49.47 µM 0.429754493303744 0.325375313272061 no 1072 0.333687119432433 1503 8056934 SGTC_2623 humulene 100 µM 0.429026694285373 0.325642730826623 no 1073 0.333951899154859 1541 6187145 An anti-inflammatory. SGTC_1909 st060837 51.5 µM 0.428864451875477 0.325702356321068 no 1074 0.334010935654332 1552 678937 SGTC_2159 5658611 73.75 µM 0.428478875651097 0.325844076821237 no 1075 0.334151254972031 1638 793844 SGTC_1009 4106-0057 9.87 µM 0.427267322996644 0.326289552865605 no 1076 0.334592315326275 1599 2928005 SGTC_1790 st045711 43.5 µM 0.424216082658951 0.327412561415663 no 1077 0.335704116441341 1714 585119 SGTC_3236 9132701 49.47 µM 0.42402249458674 0.327483864330859 no 1078 0.335774704108456 1548 24282524 SGTC_906 1165-0455 526 µM 0.422041354649614 0.328213924853725 no 1079 0.336497416259642 1553 3252859 SGTC_989 1501-0895 10.3 µM 0.421920213929631 0.328258587178823 no 1080 0.336541627559976 1689 2830112 SGTC_1202 1988-0068 29.6 µM 0.421084792827167 0.328566658177154 no 1081 0.336846582849689 1532 2850480 SGTC_2594 a-mangostin 100 µM 0.420731020185754 0.328697150992589 no 1082 0.336975753471552 1713 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2724 maprotiline 69.64 µM 0.420694229913535 0.328710722676701 no 1083 0.336989187559838 1655 4011 A tricyclic antidepressant. SGTC_1018 4259-0013 28.1 µM 0.420644252722835 0.328729159288281 no 1084 0.337007437227631 1614 6801262 SGTC_3149 9097855 49.47 µM 0.419036451460602 0.329322500209526 no 1085 0.337594746333132 1735 25236625 YMR079W SEC14 SGTC_2899 9053889 58.44 µM 0.418601020119503 0.329483265308308 no 1086 0.337753871964096 1664 6470052 SGTC_154 3389-1638 511.116 µM 0.41836078034903 0.32957197745002 no 1087 0.337841678487923 1481 5238686 SGTC_2772 vinpocetine 57.06 µM 0.416384746803068 0.330302021008891 no 1088 0.338564244061698 1645 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_716 1683-5115 658 µM 0.41584349421777 0.33050209911623 no 1089 0.338762264853028 1626 723597 SGTC_885 0865-0106 16.8 µM 0.415775608394282 0.330527197044685 no 1090 0.33878710447163 1538 2793380 SGTC_1654 st012436 41.8 µM 0.415068515234065 0.330788660301197 no 1091 0.339045873564414 1654 4323132 SGTC_2752 diclazuril 33.15 µM 0.414184481351253 0.331115667431687 no 1092 0.339369503038914 1655 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_555 4296-0685 37 µM 0.413512948800241 0.331364155733247 no 1093 0.339615418681695 1639 2908540 YHR072W ERG7 SGTC_1509 1326-1131 80 µM 0.412955481350527 0.33157049275388 no 1094 0.339819615497739 1704 768313 SGTC_967 1306-0166 352 µM 0.411620062851563 0.332064982836008 no 1095 0.340308961987064 1733 4437607 SGTC_808 0711-0032 135 µM 0.410336116436177 0.332540689332337 no 1096 0.340779700923582 1747 4252555 SGTC_2279 7948423 32.93 µM 0.409324689208748 0.332915616586635 no 1097 0.341150699661443 1781 1247112 SGTC_746 1095-0025 46.6 µM 0.408661997953057 0.333161361099861 no 1098 0.341393862874863 1706 6749286 SGTC_29 0299-0004 12.984 µM 0.408201775624987 0.333332066618702 no 1099 0.341562772338117 1572 16871 A napthoquinone isolated from Swertia calycina. SGTC_2644 guaiazulene 100 µM 0.407917875198052 0.333437388095408 no 1100 0.34166698447723 1672 3515 A coloring agent. SGTC_564 3555-0129 330 µM 0.407711828479413 0.333513835601302 no 1101 0.34174262619257 1625 563260 SGTC_572 0960-0087 17.7 µM 0.407633190571548 0.333543013681001 no 1102 0.341771496594065 1538 6796365 SGTC_1047 2043-3044 82 µM 0.40682586217936 0.333842625791914 no 1103 0.34206794524389 1559 669592 SGTC_948 3448-0295 75.3 µM 0.406296408273121 0.334039171908933 no 1104 0.342262412069963 1591 678569 SGTC_781 4335-2806 94.4 µM 0.404358607910376 0.334758918255556 no 1105 0.342974516745476 1745 845254 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.403718275169147 0.334996887133868 no 1106 0.343209949627496 1720 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_567 1080-0542 68.4 µM 0.402621047296129 0.33540480739301 no 1107 0.343613511856723 1693 5950415 SGTC_2223 6903751 107.57 µM 0.400331388135013 0.336256666776127 no 1108 0.344456226125121 1680 5598863 SGTC_2802 7925815 54.55 µM 0.400053598463006 0.336360074736238 no 1109 0.344558519887786 1595 1262923 SGTC_1319 1306-0155 43.7 µM 0.399014894395338 0.336746844787342 no 1110 0.344941114795917 1655 3122360 SGTC_196 k015-0023 18.111 µM 0.398871508649111 0.336800249232656 no 1111 0.344993941781545 1625 5211998 SGTC_2493 resveratrol 26.09 µM 0.39677773941263 0.337580454162408 no 1112 0.345765683768523 1601 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2228 7354201 200 µM 0.396033823464486 0.337857829266945 no 1113 0.346040038176705 1718 753451 SGTC_3159 9100096 49.47 µM 0.395313037952546 0.338126664014195 no 1114 0.346305939246828 1563 25236875 SGTC_237 nikkomycin 200 µM 0.394532598574205 0.338417841238089 no 1115 0.346593932339432 1709 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_964 1287-0107 19.4 µM 0.393422936193583 0.338832015939517 no 1116 0.347003566008121 1739 51516812 YPR165W RHO1 SGTC_3083 9117465 49.47 µM 0.393386109036426 0.338845764795487 no 1117 0.347017163881982 1588 16420915 SGTC_478 N-arachidonylglycine 10 µM 0.392990527398016 0.338993462686989 no 1118 0.347163238871784 1668 5283389 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.392669089607908 0.339113495798554 no 1119 0.347281951758364 1746 756377 SGTC_168 3970-0862 530.542 µM 0.391370845658822 0.339598459456784 no 1120 0.347761569493622 1657 3135186 SGTC_2626 ethyl orsellinate 100 µM 0.390398391183004 0.339961897397864 no 1121 0.348120988660756 1608 75653 A natural product. SGTC_1452 4194-0072 190 µM 0.388795624894204 0.340561227985709 no 1122 0.348713668769322 1782 1343545 SGTC_2379 9035213 200 µM 0.388786099505281 0.340564791068609 no 1123 0.348717192227878 1785 646551 SGTC_2651 TUB2.036 5 µM 0.388741011008972 0.340581657139969 no 1124 0.348733870721109 1715 15992207 YFL037W TUB2 SGTC_3 0833-0587 95.581 µM 0.38722521236258 0.341148851119427 no 1125 0.349294743260038 1645 5382644 SGTC_1089 terbinafine 2.25 µM 0.38632380184196 0.34148631867694 no 1126 0.349628437445094 1728 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.383267812029065 0.342631353663639 no 1127 0.350760601355627 1675 616764 SGTC_2182 6325192 200 µM 0.383021827974987 0.342723583398633 no 1128 0.350851789801686 1660 736248 SGTC_3329 9141233 27.5565 µM 0.382534948316207 0.342906162634948 no 1129 0.351032305689759 1731 4909101 YNL103W MET4 SGTC_1946 st076057 65.1 µM 0.380320362368632 0.343737091933811 no 1130 0.351853811079192 1603 953009 SGTC_1870 st057514 26.5 µM 0.380093669722615 0.343822191410416 no 1131 0.351937942313691 1637 5393161 SGTC_2409 alverine citrate 63.97 µM 0.379418342108188 0.344075753476026 no 1132 0.35218861600691 1790 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_220 paclitaxel 373.376 µM 0.378075120559621 0.344580294881503 no 1133 0.352687394954849 1697 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2243 6634756 200 µM 0.377837845745867 0.344669448912937 no 1134 0.352775528650849 1756 885676 SGTC_1043 0916-0009 19.3 µM 0.372564443549137 0.346653104489658 no 1135 0.35473632022118 1851 3101130 SGTC_1561 5-methoxyflavone 52.9 µM 0.370990316548579 0.347246050622222 no 1136 0.355322372078798 1725 94525 SGTC_3025 9087895 49.47 µM 0.370690705185191 0.347358951408846 no 1137 0.355433957041804 1763 17173641 SGTC_3060 1327-0027 12.5 µM 0.370226947553638 0.34753373317334 no 1138 0.355606699820204 1776 16000455 YPR107C YTH1 SGTC_2340 7987427 183.45 µM 0.369587173292161 0.347774905588469 no 1139 0.355845054837867 1711 2239331 SGTC_2764 methyldopa 94.69 µM 0.368573944418065 0.348156983288893 no 1140 0.356222659815332 1778 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3323 9138564 53.9225 µM 0.364994974563434 0.349507806136779 no 1141 0.357557578786059 1803 43912313 YNL103W MET4 SGTC_409 arachidonic acid 100 µM 0.364863150013238 0.349557597663806 no 1142 0.357606781398929 1688 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3311 9131146 2.8755 µM 0.36463322532985 0.349644448842798 no 1143 0.357692604879591 1667 4900406 YPR165W RHO1 SGTC_1794 st048918 76.9 µM 0.364185906625822 0.349813440445615 no 1144 0.357859595161514 1799 672303 SGTC_588 3970-1144 52.9 µM 0.36283714887631 0.350323164846659 no 1145 0.358363269722844 1753 1888707 SGTC_3308 9128332 17.569 µM 0.362487335015038 0.350455411069886 no 1146 0.35849394307308 1800 17332805 YDL196W YDL196W SGTC_2218 6965428 192.983 µM 0.361897203496785 0.350678549842438 no 1147 0.358714424896625 1755 675684 SGTC_2399 5884133 200 µM 0.36181184259642 0.350710830519146 no 1148 0.358746320885886 1625 722445 SGTC_2593 nobiletin 86.24 µM 0.360665831516482 0.351144318396651 no 1149 0.359174635170563 1636 72344 An anti-infammatory. SGTC_2935 9038016 29.96 µM 0.359962934958322 0.351410290558287 no 1150 0.359437425886641 1781 6463195 SGTC_3194 9111903 49.47 µM 0.357097999140931 0.352495117998326 no 1151 0.360509221160433 1730 17087251 SGTC_172 1112-0046 2.638 µM 0.35658289630627 0.352690292814511 no 1152 0.360702041806966 1697 2802135 YIL048W NEO1 SGTC_2299 7976368 114.88 µM 0.35589645617196 0.352950448385412 no 1153 0.360959054921622 1797 2979718 SGTC_1238 0333-0287 48.8 µM 0.354921562941404 0.353320043629451 no 1154 0.361324176944891 1677 7226 SGTC_792 4534-1957 155 µM 0.353687765328841 0.353787991385005 no 1155 0.361786446279038 1729 1717904 SGTC_1636 st007707 68.9 µM 0.352981648857478 0.354055902710383 no 1156 0.362051099121442 1822 403051 SGTC_1959 st077091 55.8 µM 0.352896090700974 0.354088369687063 no 1157 0.362083170849025 1681 821356 YKL052C ASK1 SGTC_3168 9103419 49.47 µM 0.352329013579171 0.354303586726865 no 1158 0.362295765851912 1748 16649256 SGTC_3297 9117502 71.43 µM 0.351395928933122 0.354657812158349 no 1159 0.362645668076452 1715 7453720 SGTC_703 3875-0075 71.8 µM 0.351125209458291 0.354760608502132 no 1160 0.362747208055878 1746 2850814 SGTC_1112 tnp00069 1.16933 µM 0.350455729143881 0.355014865867504 no 1161 0.362998354505854 1794 145826 SGTC_3264 9137442 49.47 µM 0.350299853339375 0.355074074149099 no 1162 0.363056837659028 1789 17015726 SGTC_2744 captopril 92.04 µM 0.34775333291891 0.356041845920875 no 1163 0.364012719791905 1821 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1991 st073000 8.92 µM 0.347014361432645 0.356322856408504 no 1164 0.364290264773014 1783 4301969 YIL048W NEO1 SGTC_916 4466-0038 42 nM 0.345501277678288 0.35689848379099 no 1165 0.364858774949019 1833 5722064 YGL116W CDC20 SGTC_1508 1080-0625 72.9 µM 0.344513943154895 0.357274274519953 no 1166 0.365229905992391 1714 767111 SGTC_127 0180-0333 59.125 µM 0.343999004308598 0.357470321056721 no 1167 0.36542351744822 1744 771601 SGTC_3111 9122088 49.47 µM 0.340868899248302 0.358662816345603 no 1168 0.36660113947114 1807 16876704 SGTC_2513 baicalein 25.65 µM 0.340258644642467 0.358895469801807 no 1169 0.366830878927503 1629 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2048 5246248 200 µM 0.339254387346811 0.359278446774988 no 1170 0.367209050399558 1829 677046 SGTC_2946 9065502 71.43 µM 0.337439009777142 0.359971105944174 no 1171 0.367892990850232 1700 16489101 SGTC_774 k060-0086 136 µM 0.336650197167034 0.360272221723636 no 1172 0.368190305409683 1891 5911235 SGTC_3092 9117248 49.47 µM 0.336081401815957 0.360489403471198 no 1173 0.368404741379447 1822 17141857 SGTC_2520 obtusaquinone 4.71 µM 0.335288595660162 0.360792193808411 no 1174 0.368703697850784 1812 5967872 SGTC_439 amiodarone 34.4 µM 0.333078507377599 0.36163673604056 no 1175 0.369537511306823 1790 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1324 1418-0026 34.4 µM 0.332865034997912 0.361718346140658 no 1176 0.369618081906932 1766 1372513 SGTC_2180 6301957 200 µM 0.332048386332635 0.362030607458719 no 1177 0.369926361358516 1834 845462 SGTC_1156 4092-0367 4.88 µM 0.330720821499327 0.362538423359274 no 1178 0.370427686619596 1749 1357585 SGTC_2539 epi(13)torulosol 80 µM 0.33062460744537 0.362575236267422 no 1179 0.370464028277446 1673 6708597 SGTC_806 3966-4455 5.86 µM 0.328913429310263 0.363230170062552 no 1180 0.371110561726456 1675 714982 SGTC_1422 4031-0024 15.5 µM 0.327880356748441 0.363625760541837 no 1181 0.371501063252767 1821 782427 SGTC_1225 1216-0074 20.6 µM 0.325839081660994 0.364407845382545 no 1182 0.372273054033698 1718 4241466 SGTC_2288 7946289 167.31 µM 0.325145630875148 0.364673659655949 no 1183 0.372535427539762 1857 1246052 SGTC_3012 9080433 71.4286 µM 0.323295665977979 0.365383108170251 no 1184 0.373235667984217 1882 17688859 SGTC_1997 st073024 93.8 µM 0.322878971641146 0.365542971195606 no 1185 0.373393451146584 1845 686268 SGTC_784 4579-0127 173 µM 0.322529697483953 0.365676986749975 no 1186 0.373525721714678 1880 1948547 SGTC_1793 st048256 72.231 µM 0.32209639213956 0.365843267631522 no 1187 0.373689835708917 1754 672022 SGTC_2787 5284540 71.43 µM 0.317722084856677 0.367523314409479 no 1188 0.375347878661451 1723 736958 SGTC_255 tunicamycin 200.472 nM 0.31621839913673 0.368101425223534 no 1189 0.375918371624642 1877 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_812 4251-0442 148 µM 0.312174753835804 0.369657534387022 no 1190 0.377453858780045 1876 5723007 SGTC_2848 9016370 25.97 µM 0.31206894889281 0.369698279925306 no 1191 0.377494062063884 1923 7894410 SGTC_3237 9133362 49.47 µM 0.310979096871829 0.370118067582689 no 1192 0.377908256294188 1814 43845137 SGTC_1081 sertraline 6 µM 0.310666532647798 0.370238489208455 no 1193 0.378027071098786 1859 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_609 0986-0026 86.3 µM 0.309074967699297 0.370851868529023 no 1194 0.378632250222208 1820 2848610 SGTC_1647 st011722 22.4 µM 0.30638503715653 0.371889296895427 no 1195 0.379655749775233 1806 2854783 SGTC_634 1611-4317 11.2 µM 0.305827815895947 0.372104317644434 no 1196 0.379867874256932 1897 2843522 SGTC_3010 9080089 71.4286 µM 0.30492169531965 0.372454056935778 no 1197 0.380212895831033 1866 17027233 SGTC_1710 st031758 61.5 µM 0.303501155433258 0.373002560539991 no 1198 0.38075398353208 1872 5394341 SGTC_2720 fluspirilene 36.88 µM 0.303427384639904 0.373031052208727 no 1199 0.38078208941987 1832 3396 An atypical antipsychotic. SGTC_1390 3413-2614 145 µM 0.301645362395274 0.373719513395333 no 1200 0.381461211773988 1766 3421432 SGTC_3103 9120822 49.47 µM 0.298912913117901 0.374775942111938 no 1201 0.382503247034106 1886 17141819 SGTC_1330 1469-0054 61.8 µM 0.298383101721392 0.374980888669826 no 1202 0.382705392431498 1925 7102664 SGTC_3215 9129942 49.47 µM 0.298365530918469 0.374987686175954 no 1203 0.382712096981832 1939 17682944 SGTC_2879 9041815 71.43 µM 0.297638343884628 0.375269042490833 no 1204 0.382989602989393 1861 4942971 SGTC_131 0141-0277 33.849 µM 0.297629278611517 0.375272550359537 no 1205 0.382993062819535 1882 1547771 SGTC_2794 7785382 27.27 µM 0.296830406400909 0.375581719835259 no 1206 0.383297995078209 1963 2205081 SGTC_190 3970-0790 3.722 µM 0.295509529181877 0.376093084342076 no 1207 0.383802336987891 1870 2832352 SGTC_811 0416-0114 265 µM 0.295346478035361 0.376156223083413 no 1208 0.383864607409967 1779 6612453 SGTC_761 k216-0224 480 µM 0.29393684693307 0.376702216428456 no 1209 0.384403080679231 1965 1340404 SGTC_1386 3228-0095 33.8 µM 0.293161710796492 0.377002555626753 no 1210 0.384699274644677 1881 870181 SGTC_2432 5630864 12.22 µM 0.292322732619124 0.377327715350976 no 1211 0.385019939698278 1765 5714970 SGTC_1404 3909-7820 48.3 µM 0.291747320318252 0.377550776109133 no 1212 0.385239912971732 1892 23741373 SGTC_1624 st003710 6.25 µM 0.289778708196374 0.378314224575028 no 1213 0.385992768855851 1894 24207033 SGTC_1785 bathophenanthroline 24 µM 0.289241145532733 0.37852277976512 no 1214 0.386198423606201 1743 72812 An iron chelator. SGTC_1367 1812-0510 76.9 µM 0.289168771954175 0.378550860843127 no 1215 0.386226113929375 1830 1142582 YDR527W RBA50 SGTC_2696 st077691 74.316 µM 0.28624774019448 0.379684760149842 no 1216 0.387344190673651 1814 757133 SGTC_2697 mebhydrolin 72.4 µM 0.284742657282979 0.380269414860594 no 1217 0.387920653520867 1918 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2863 9028737 58.44 µM 0.283741565645894 0.380658444034973 no 1218 0.38830421923512 1932 6460917 SGTC_1283 0922-0125 16.4 µM 0.28248753765235 0.38114593579882 no 1219 0.388784850572649 1866 3360884 SGTC_475 α-linolenic acid 10 µM 0.282147347241168 0.381278214236148 no 1220 0.388915264752783 1899 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3162 9099653 49.47 µM 0.281993593249623 0.381338003947234 no 1221 0.388974211441739 1893 25237511 SGTC_1976 st070609 63.5 µM 0.281904121651193 0.381372797720133 no 1222 0.389008514521062 1824 682556 SGTC_1792 st045773 43.6 µM 0.280836407297759 0.381788085083864 no 1223 0.389417938947158 1801 2919270 SGTC_3005 9076496 71.4286 µM 0.280357796510297 0.381974284891617 no 1224 0.389601506329451 1909 21368410 SGTC_1933 st074711 15.9 µM 0.280239187336509 0.382020433092467 no 1225 0.389647001750208 1895 17250958 SGTC_1071 trifluoperazine 6.31 µM 0.279482441588964 0.38231490553208 no 1226 0.389937305484813 1875 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1678 st019265 80.2 µM 0.279360029145909 0.382362546281785 no 1227 0.389984271270696 1972 5367020 SGTC_1952 st077036 64.1 µM 0.278769077572855 0.382592559179111 no 1228 0.390211023294511 1915 2937007 SGTC_1349 flufenamic acid 69 µM 0.278371082199646 0.382747492122382 no 1229 0.390363757806151 1795 3371 A non-steroidal anti-inflammatory. SGTC_1008 4106-0037 6 µM 0.2774236587554 0.383116383688159 no 1230 0.390727408616178 1828 2905394 SGTC_2325 6158266 200 µM 0.276846692701402 0.383341084844354 no 1231 0.390948913122547 1804 3623240 SGTC_2540 epiandrosterone 100 µM 0.275986541569061 0.383676146129345 no 1232 0.391279201609117 1849 441302 A steroid. SGTC_2876 9059903 25.97 µM 0.274389215955724 0.384298595269836 no 1233 0.391892764764916 1843 6916095 SGTC_1121 fusaric acid 630.51 nM 0.273931089544954 0.384477174066343 no 1234 0.392068789533567 1773 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.272082369543692 0.385198058398753 no 1235 0.392779342707723 1898 688751 SGTC_129 0088-0017 176.636 µM 0.271064983546805 0.385594944322481 no 1236 0.393170526366255 1948 182446 SGTC_1835 st008666 49.2 µM 0.269080910606457 0.386369282620772 no 1237 0.393933709994027 1771 690455 SGTC_96 0929-0093 37.281 µM 0.26862104390923 0.386548822820315 no 1238 0.394110658310655 1794 6991579 SGTC_1812 st052057 4.327 µM 0.267693732488738 0.386910935649669 no 1239 0.39446753727709 1791 3645418 SGTC_895 0964-0006 13.7 µM 0.266841598726045 0.387243778610877 no 1240 0.394795561989787 1937 6738897 SGTC_2870 9038528 12.99 µM 0.266738179504601 0.387284179746582 no 1241 0.394835377792348 1830 6463316 SGTC_449 xestospongin c 11.1929 µM 0.264871771656013 0.388013508930079 no 1242 0.395554122418398 1912 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.264588310265814 0.388124310702352 no 1243 0.395663313172519 1832 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2170 morpholine 200 µM 0.264309334585423 0.38823336795517 no 1244 0.395770784004991 1928 121171 Reacts with secondary amines. SGTC_2804 7954240 19.48 µM 0.26368052644697 0.388479214121031 no 1245 0.396013051138217 1925 828705 SGTC_2881 9058953 51.95 µM 0.261982397351777 0.389143357491849 no 1246 0.396667506615855 1860 17122249 SGTC_2722 naftopidil 47.16 µM 0.261010392811682 0.389523657317805 no 1247 0.397042246342654 1922 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2552 juarezic acid 87.02 µM 0.260646648766571 0.389666000545685 no 1248 0.397182506105256 1957 1549512 SGTC_191 3914-0123 66.505 µM 0.260225229006508 0.389830932402356 no 1249 0.397345022260303 1816 3144412 SGTC_694 1315-0438 43.2 µM 0.259579409194979 0.390083726624844 no 1250 0.397594110541903 1895 6793154 SGTC_1180 1193-0155 285 µM 0.259171073080823 0.390243586243142 no 1251 0.397751624542489 1825 2921347 SGTC_1621 st003705 32.4 µM 0.258935462813182 0.390335833818132 no 1252 0.397842517834069 1967 24207032 SGTC_2450 5739737 12.93 µM 0.258433975166931 0.39053219988406 no 1253 0.398035999264016 1847 2262825 SGTC_2771 fluoxetine 41.05 µM 0.257873636152965 0.390751643240734 no 1254 0.398252216093319 1931 3386 A selective serotonin reuptake inhibitor. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.257545848004618 0.390880029755972 no 1255 0.398378713501283 1818 2724 A muscle relaxant with antifungal properties. SGTC_3254 9136651 49.47 µM 0.257008474942947 0.391090531229202 no 1256 0.398586115359312 1836 16454030 SGTC_2412 st077135 33.4 µM 0.256286648882317 0.391373337422593 no 1257 0.398864752860356 1912 13258915 SGTC_2971 9092186 9.93 µM 0.25504184737771 0.391861176431563 no 1258 0.399345389070797 1702 25236400 SGTC_2386 9075165 157.42 µM 0.255005308356511 0.391875498685125 no 1259 0.399359499634527 1877 16452277 SGTC_101 0490-5701 117.494 µM 0.254758293446244 0.391972325323208 no 1260 0.399454894790238 1958 4661669 SGTC_413 propylparaben 100 µM 0.252909691377252 0.392697165344172 no 1261 0.400169000125461 1815 7175 A pharmaceutical preservative. SGTC_1087 pterostilbene 9.05 µM 0.252353743284253 0.392915226474234 no 1262 0.400383825394253 1963 5281727 Similar to reservatol, lowers cholesterol. SGTC_2360 9040895 200 µM 0.251080970579745 0.393414576247711 no 1263 0.40087575401257 1818 4914414 SGTC_602 3130-1533 38.1 µM 0.250655850154508 0.393581403810655 no 1264 0.40104009878012 1954 720941 SGTC_3315 9136395 68.55 µM 0.250531469530081 0.393630217479186 no 1265 0.401088185656088 2008 16876844 SGTC_1649 st011737 51.3 µM 0.250160667027687 0.393775750306969 no 1266 0.401231550747975 1854 1761035 SGTC_1300 1094-0077 113 µM 0.249996466785582 0.393840200475083 no 1267 0.401295040499045 1829 5532636 SGTC_2825 7998094 58.44 µM 0.249914385494342 0.393872419258503 no 1268 0.401326779070989 1868 2987815 SGTC_3163 9099914 49.47 µM 0.249528541670545 0.394023881510836 no 1269 0.401475982958379 1960 16268368 SGTC_1588 farnesol 29.9 µM 0.249455134470756 0.394052699181874 no 1270 0.401504370784584 1837 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_959 1222-0044 107 µM 0.249122662525083 0.39418322589042 no 1271 0.40163294990882 2017 6083612 SGTC_2763 lisinopril 49.32 µM 0.248897282563985 0.394271715618504 no 1272 0.401720118683261 1987 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3086 9117350 49.47 µM 0.248702580732818 0.394348164750436 no 1273 0.401795426209489 1872 2679265 SGTC_930 2810-3379 265 µM 0.248700278981632 0.394349068550979 no 1274 0.401796316511518 1997 1015764 SGTC_2026 5148700 152 µM 0.248574373508641 0.39439850718262 no 1275 0.401845016686211 1845 79838 SGTC_829 1635-0120 117 µM 0.248538596985595 0.394412555669827 no 1276 0.401858855305752 1974 285054 SGTC_1143 3454-2408 5.08 µM 0.241979196247523 0.396990560615559 no 1277 0.404398141629352 1898 X1143 SGTC_281 1672-3440 14.9 µM 0.241545777036848 0.397161064969989 no 1278 0.404566070806022 1973 6833000 SGTC_3033 9090887 49.47 µM 0.241527063883276 0.397168427048201 no 1279 0.40457332165253 1828 19325384 SGTC_2857 9024691 58.44 µM 0.240906881075994 0.397412438403407 no 1280 0.404813644429264 1868 16478292 SGTC_1272 0839-0021 27 µM 0.240129400581406 0.397718395353129 no 1281 0.40511497126583 1904 5027250 SGTC_2747 doxorubicin 7.63 µM 0.239942605077632 0.397791913180691 no 1282 0.405187375680952 1988 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2860 9025725 38.96 µM 0.239178865128789 0.398092538994263 no 1283 0.405483445150472 1792 40546248 SGTC_2438 5259590 200 µM 0.237192380720166 0.398874748419183 no 1284 0.406253773492961 1977 1201127 SGTC_1320 1313-0481 95.3 µM 0.236226208721427 0.399255340881807 no 1285 0.406628571658507 2003 6813365 YLR208W SEC13 SGTC_979 1426-2828 121 µM 0.235761727431297 0.399438342497274 no 1286 0.406808784059306 1953 747872 SGTC_1880 MG-132 525 µM 0.23520923422418 0.399656048819954 no 1287 0.407023169578844 1981 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1172 0370-0043 85 µM 0.234804483800367 0.399815557873435 no 1288 0.407180243729043 1929 376585 SGTC_2947 9072639 7.68 µM 0.234699252459596 0.399857031481445 no 1289 0.407221083991452 1829 16488146 SGTC_3131 9127911 49.47 µM 0.234258954675911 0.400030573188121 no 1290 0.407391974408185 1917 45595681 SGTC_2227 7312221 64.1025 µM 0.233851721655694 0.400191100120493 no 1291 0.407550047267629 1964 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_120 rhodamine 6G 52.259 µM 0.232915317180762 0.400560284753854 no 1292 0.407913582062126 1995 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2718 lomofungin 53.02 µM 0.232819967662433 0.400597882021247 no 1293 0.407950603497429 1988 5351222 A RNA synthesis inhibitor. SGTC_3337 9144342 33.5465 µM 0.231659935181605 0.401055368074134 no 1294 0.408401075983354 1955 17682949 SGTC_1929 genistein trimethyl ether 50.5 µM 0.23117067058775 0.4012483617828 no 1295 0.4085911072027 2056 136420 SGTC_2712 st079126 47.7 µM 0.230797203398355 0.401395694646042 no 1296 0.408736176976617 1893 3152970 SGTC_458 nppb 133 µM 0.229778268922571 0.401797735700339 no 1297 0.409132035915876 2044 4549 A chloride channel blocker. SGTC_2131 toluylene red 5.2905 µM 0.229540252593265 0.401891664814394 no 1298 0.40922451930565 1850 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1178 0988-0033 191 µM 0.228974414427147 0.402114986006385 no 1299 0.409444401099968 1949 5392207 SGTC_1968 st069590 43.6 µM 0.227668411732118 0.402630552235348 no 1300 0.409952015669904 1991 6384066 SGTC_2079 5212404 121 µM 0.227279005568673 0.402784309600532 no 1301 0.410103398547018 2041 758462 SGTC_1327 1436-0082 2.18 µM 0.226730543142793 0.403000895969175 no 1302 0.41031663776936 1903 15992205 SGTC_702 1488-0190 94 µM 0.226390982062687 0.403135002668945 no 1303 0.41044867057449 2036 949357 SGTC_1694 st024011 44.9 µM 0.225256973815683 0.403582951858647 no 1304 0.410889684714387 1985 2787533 SGTC_862 0452-0056 10.2 µM 0.225061738963441 0.403660085149641 no 1305 0.410965622644819 1994 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_160 3453-0671 289.699 µM 0.224684600398118 0.403809095479463 no 1306 0.411112322714061 1895 5322268 SGTC_2329 6138490 200 µM 0.224059364270141 0.404056161802115 no 1307 0.411355555619096 1886 720019 SGTC_2608 thymoquinone 42.66 µM 0.221810904167018 0.404944971822631 no 1308 0.412230545298972 2018 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2475 5812728 15.03 µM 0.22146478504846 0.405081835432968 no 1309 0.412365276647396 1992 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1656 st012921 11 µM 0.221043392196208 0.405248479711959 no 1310 0.412529323211209 1984 6732821 SGTC_2482 5981709 142.65 µM 0.220981149895081 0.405273095547911 no 1311 0.412553555187751 1940 877755 SGTC_2053 5265679 138 µM 0.220559936874546 0.405439688413579 no 1312 0.412717549268812 1905 764595 SGTC_1982 st072467 71.9 µM 0.219668621475531 0.405792266694796 no 1313 0.413064622096284 1881 3163533 SGTC_3339 9145883 14.936 µM 0.21957022582726 0.40583119382291 no 1314 0.413102940936963 1999 2030670 SGTC_327 1273-0057 3.96 µM 0.217686229381692 0.40657671663761 no 1315 0.413836796877837 2012 3108138 SGTC_1717 st033143 58.0435 µM 0.215454739433136 0.407460185381609 no 1316 0.414706398030575 2022 674616 SGTC_3262 9137218 49.47 µM 0.214730124899971 0.407747168880765 no 1317 0.41498886705706 1965 17650664 SGTC_2580 diallyl disulphide 81.36 µM 0.214485890857083 0.407843908907826 no 1318 0.415084084211915 1891 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1076 itraconazole 331 nM 0.214187565484279 0.407962081894982 no 1319 0.415200396195285 2030 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_8 0354-0001 70 µM 0.213103359030115 0.408391629428996 no 1320 0.415623172347509 1937 4993152 SGTC_1625 st003711 30.1 µM 0.21253292662464 0.408617671055196 no 1321 0.415845646372288 1997 24207034 YER133W GLC7 SGTC_1014 4130-3005 69.3 µM 0.212018239996168 0.408821648750526 no 1322 0.416046402167792 1878 743608 SGTC_3284 9108171 64.8615 µM 0.211829078026283 0.408896622562794 no 1323 0.416120191138964 1932 8687505 SGTC_1707 st032323 6.317 µM 0.21069903968818 0.409344579414229 no 1324 0.416561062001275 1968 3132057 YMR211W DML1 SGTC_397 arbidol 50 µM 0.208725142372414 0.410127332878552 no 1325 0.41733140581869 2019 131410 A RNA synthesis inhibitor. SGTC_1237 0330-0133 46.1 µM 0.20858310141524 0.410183673396175 no 1326 0.41738685176698 1913 X1237 YHR072W ERG7 SGTC_1979 st071809 45.3 µM 0.207512640955321 0.410608330882836 no 1327 0.417804760737121 2014 4976333 SGTC_2007 4011539 71.82 µM 0.206822170640524 0.41088229985206 no 1328 0.418074370411291 1917 45595301 SGTC_3067 9117431 49.47 µM 0.206789757247399 0.410895162102859 no 1329 0.418087027897292 1900 17150885 SGTC_2956 9076196 2.52 µM 0.206273377846334 0.411100084181165 no 1330 0.418288686378733 2053 16423868 SGTC_38 0929-0051 58.268 µM 0.204489104621033 0.411808348754574 no 1331 0.418985652684102 2060 1379719 SGTC_1325 1431-0015 227 µM 0.204263312359159 0.411897997188333 no 1332 0.419073869008412 1854 1103340 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.203143737328788 0.412342580476102 no 1333 0.419511343460486 1888 688669 SGTC_3161 9100388 49.47 µM 0.203005082464493 0.412397648168881 no 1334 0.41956552984739 1982 25236368 SGTC_1782 st039423 80.636 µM 0.202623741360197 0.412549109191429 no 1335 0.41971456599525 1876 2068169 SGTC_122 0236-0016 402.397 µM 0.201519487214596 0.4129877701228 no 1336 0.420146196692045 1961 6808838 SGTC_2780 5215298 71.43 µM 0.201256515461637 0.41309225073335 no 1337 0.420249001232891 2104 2834131 SGTC_1563 conessine 56.1 µM 0.200941003437067 0.413217614102941 no 1338 0.420372352720292 2057 441082 An anti-amoebic, histamine inhibitor. SGTC_1740 st038286 13.222 µM 0.200378448853133 0.413441157604021 no 1339 0.420592306505879 1984 716786 SGTC_1975 st070967 30.8 µM 0.199309108492981 0.413866160946474 no 1340 0.421010477282094 2083 261391 SGTC_1611 st001856 99.4 µM 0.198916398084001 0.414022266861171 no 1341 0.421164071009669 1895 647478 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.198202279634843 0.414306170156968 no 1342 0.421443401989016 1938 15053 SGTC_2707 st078556 66.6 µM 0.197363933938964 0.414639518085998 no 1343 0.421771375517841 2084 17250899 SGTC_553 k007-0256 45.7 µM 0.196067655740015 0.415155072771267 no 1344 0.422278605929428 1952 6287000 SGTC_501 nsc-95397 161 µM 0.19430191722412 0.41585757576636 no 1345 0.422969742257887 2039 262093 SGTC_406 estrone 100 µM 0.194074928648199 0.415947903233458 no 1346 0.423058606210938 2082 5870 A steroid. SGTC_822 1487-0950 154 µM 0.192529335999674 0.416563071692361 no 1347 0.423663795462041 2083 1958375 SGTC_2770 toltrazuril 17.5 µM 0.192380694775876 0.416622243869385 no 1348 0.423722006646422 2074 68591 Kills coccidiodes. SGTC_3352 9151559 45.5865 µM 0.192308818506848 0.416650857573908 no 1349 0.423750155577145 1947 17159339 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.190555033756783 0.41734916996657 no 1350 0.424437111202419 2084 5024745 SGTC_627 1391-0720 175 µM 0.189552392950802 0.417748513285392 no 1351 0.424829947831597 1984 997839 SGTC_610 4215-0184 155 µM 0.18950953396623 0.417765585548573 no 1352 0.424846741732377 1999 5605015 SGTC_51 1013-0126 23.419 µM 0.187093143476012 0.418728369883465 no 1353 0.425793801977323 2128 1627850 SGTC_2489 cantharidin 73.42 µM 0.1862418887329 0.419067659316378 no 1354 0.42612753805241 2027 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3334 9142812 21.919 µM 0.184122137698119 0.419912801580989 no 1355 0.426958819997429 2023 45283678 SGTC_837 0091-0265 12.5 µM 0.18296942506103 0.420372542105484 no 1356 0.427411004435279 1951 759367 SGTC_1552 6-methylflavone 10.6 µM 0.181000702180022 0.421157985853885 no 1357 0.428183512429104 2103 689013 SGTC_3125 9127534 49.47 µM 0.180999543623954 0.421158448165345 no 1358 0.428183967116747 2118 1639235 SGTC_560 2332-1943 155 µM 0.18098597602923 0.421163862201043 no 1359 0.428189291870601 2020 21177716 SGTC_1407 3909-7909 12.3 µM 0.180154162713754 0.421495818813277 no 1360 0.428515771220266 1987 4411780 SGTC_1827 berberine 7.24 µM 0.179721233791464 0.421668612388611 no 1361 0.428685711356356 1855 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2063 5246145 200 µM 0.178432061501409 0.422183244925648 no 1362 0.429191835930376 2032 711240 SGTC_1809 st050081 57.6 µM 0.178062964143549 0.422330611656262 no 1363 0.429336763750331 2060 5036894 SGTC_2401 5128683 200 µM 0.177353234597196 0.422614010582035 no 1364 0.429615469158426 1947 708373 SGTC_1944 st076371 56.9 µM 0.17696093009303 0.42277067713742 no 1365 0.429769539225394 1915 24208455 SGTC_1808 st050063 61.5 µM 0.17670272333007 0.422873798512405 no 1366 0.429870950815698 2087 4011993 SGTC_2380 9035439 200 µM 0.17648468898676 0.4229608801356 no 1367 0.429956588154144 2065 6462575 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.176288695604186 0.423039161942734 no 1368 0.430033571278138 1945 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3354 9151612 71.43 µM 0.176218322998621 0.423067270239082 no 1369 0.430061213182043 2087 27261949 SGTC_2908 7930301 100 µM 0.176088306211192 0.423119202704119 no 1370 0.430112283836076 2050 2223178 SGTC_1564 D-Arginine 115 µM 0.175936165923751 0.423179973631006 no 1371 0.430172046095662 1897 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_291 SEC14.278 35.5 µM 0.175106634578773 0.423511353803395 no 1372 0.430497922588986 2086 1068044 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.175082535380848 0.423520981731576 no 1373 0.430507390525334 2005 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_502 l-744,832 89.3 µM 0.174779614561058 0.423642006244947 no 1374 0.430626403494662 2096 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_500 h-89 112 µM 0.174279302323569 0.42384190938033 no 1375 0.430822982334079 2118 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2549 cedrol 20.94 µM 0.171830605494143 0.42482058452286 no 1376 0.431785351833135 2090 6708665 A sedative which affects the nervous system. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.171245810043933 0.425054379593262 no 1377 0.432015244124984 1968 688667 SGTC_2175 5807670 165.306 µM 0.170855619036335 0.425210388522038 no 1378 0.432168647159347 2097 241186 SGTC_2270 7924575 90.91 µM 0.170559208332723 0.425328909375689 no 1379 0.432285187438555 2134 1262135 SGTC_2788 5282734 71.43 µM 0.170227310736061 0.425461627795524 no 1380 0.432415687149064 2082 743706 SGTC_676 falcarinol 140 µM 0.169994866895992 0.425554581914229 no 1381 0.432507086759942 2111 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_88 0180-0332 8.668 µM 0.169889568399461 0.425596692066744 no 1382 0.43254849253763 2082 3101745 SGTC_2719 novobiocin 32.65 µM 0.169454741974036 0.425770593438519 no 1383 0.432719484075385 2089 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_973 1325-0077 65.9 µM 0.169252977054841 0.425851290764087 no 1384 0.432798830576654 2071 2835149 SGTC_205 1486-1330 71.903 µM 0.167846345722468 0.426413969159379 no 1385 0.433352080528227 2021 4118834 SGTC_2545 solidagenone 89.61 µM 0.167603026028145 0.426511316741523 no 1386 0.433447795226387 2064 6708572 An anti ulcer agent SGTC_456 gingerol 170 µM 0.167340519901453 0.426616345470822 no 1387 0.433551061670912 2045 442793 A herb. SGTC_3276 9139060 49.47 µM 0.16671627910402 0.426866125167858 no 1388 0.433796647966537 2114 4870619 SGTC_928 2764-0428 58.7 µM 0.164055011006802 0.427931315715168 no 1389 0.434843918943795 2030 662578 SGTC_2103 5378138 10 µM 0.163698441204524 0.428074075274372 no 1390 0.434984272366644 2075 244142 SGTC_738 1315-0003 72.4 µM 0.163385105210808 0.428199533121468 no 1391 0.435107614810601 2111 6251474 SGTC_2532 xanthone 78.9 µM 0.162414646612367 0.428588144901335 no 1392 0.435489668820384 2094 7020 An insecticide. SGTC_1879 gemcitabine 100 µM 0.162312352799999 0.428629111617641 no 1393 0.435529943770856 2068 60750 A nucleoside analog which inhibits DNA replication. SGTC_1893 st059353 36.1 µM 0.161424359187939 0.428984768349941 no 1394 0.435879591200118 1971 3112488 SGTC_1689 st020265 53.493 µM 0.161203006514557 0.42907343289731 no 1395 0.43596675661635 2121 5758320 YPR016C TIF6 SGTC_1874 staurosporine 7.6 µM 0.159565437440563 0.429729484904515 no 1396 0.436611703496996 2099 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_283 0987-0079 11.7 µM 0.158966901791742 0.429969322107986 no 1397 0.436847475366457 2111 411556 SGTC_936 3005-4620 401 µM 0.158806951024926 0.430033419820542 no 1398 0.436910486094517 2145 777207 SGTC_2972 9093619 59.92 µM 0.158096489821678 0.430318148051746 no 1399 0.437190383272328 1910 25236256 SGTC_1195 1502-0147 41.1 µM 0.157886694895817 0.430402233524609 no 1400 0.437273041246718 2040 817940 SGTC_2044 5102272 200 µM 0.157460796568283 0.430572942600017 no 1401 0.437440851115388 2042 592666 SGTC_1956 st077085 54 µM 0.157360582073025 0.430613112580357 no 1402 0.437480338658001 1987 24208685 SGTC_3341 9147222 25.867 µM 0.156036386377945 0.431143970477319 no 1403 0.438002170147948 2043 1939759 SGTC_935 2996-0153 430 µM 0.15508342400451 0.431526081386063 no 1404 0.438377774903499 2138 23738523 SGTC_2740 felodipine 17.08 µM 0.154619165131102 0.43171225927661 no 1405 0.438560780056294 2138 3333 L-type calcium channel blocker SGTC_692 k241-0027 77.8 µM 0.154581550829145 0.431727344093423 no 1406 0.43857560772853 2125 3600480 SGTC_1459 k035-0031 35.7 µM 0.154566947691505 0.431733200553702 no 1407 0.438581364353038 1941 3877128 YMR208W ERG12 SGTC_1278 0874-0585 172 µM 0.154449341966092 0.431780365845357 no 1408 0.438627725548405 2052 766306 SGTC_1859 st055998 20 µM 0.153789092351597 0.432045174269754 no 1409 0.438888017280839 2164 676301 SGTC_3268 9137683 49.47 µM 0.153647006526461 0.432102165082604 no 1410 0.438944035564086 2012 1953228 SGTC_2910 7948405 25.97 µM 0.151677638961999 0.432892226022017 no 1411 0.439720597306755 2124 2971328 SGTC_1558 st069300 45.6 µM 0.150148406904876 0.433505900864892 no 1412 0.440323764825049 2146 24208000 SGTC_2605 digitonin 300 nM 0.149515029854961 0.433760119640988 no 1413 0.44057362527925 2168 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_632 0781-2353 4.65 µM 0.149229212432186 0.433874847263112 no 1414 0.440686384941759 2080 6811515 YHR007C ERG11 SGTC_1434 4073-0095 163 µM 0.147509559421082 0.434565236299067 no 1415 0.44136491747078 2129 24133745 SGTC_1676 st018489 23.4 µM 0.147077338530834 0.434738791474732 no 1416 0.44153548828731 1973 3696235 SGTC_2824 7998404 51.95 µM 0.146619326269245 0.434922716712961 no 1417 0.441716249193484 2062 837851 SGTC_2402 5553605 200 µM 0.14580082001968 0.435251441555637 no 1418 0.442039314270223 2099 6758546 SGTC_1650 st011916 45.8 µM 0.145457925761589 0.435389166537945 no 1419 0.442174666382106 2139 242528 SGTC_700 3453-2283 142 µM 0.140419911355535 0.437413602037401 no 1420 0.444164113362913 2128 565664 SGTC_2430 5571206 200 µM 0.140387310910435 0.437426707336294 no 1421 0.444176991496745 2161 1731771 SGTC_2495 cafestol 54.53 µM 0.138498140880306 0.438186265848993 no 1422 0.444923369410089 2088 16667697 An anti-infammatory. SGTC_364 0083-0097 67.7 µM 0.138283552510648 0.438272557571516 no 1423 0.445008161909197 2051 5207356 SGTC_1720 st037298 9.481 µM 0.137774211990571 0.43847738875989 no 1424 0.44520943290968 2048 597396 SGTC_3280 9140961 49.47 µM 0.137623448319066 0.438538021503821 no 1425 0.445269011393751 1999 4901226 SGTC_159 3970-0959 50 µM 0.137119489158493 0.438740709616912 no 1426 0.445468173924813 2131 6615653 SGTC_2587 piperic acid 92.2 µM 0.137014499760822 0.438782937488853 no 1427 0.445509667025145 2046 5370536 SGTC_2087 5276107 200 µM 0.136055373062402 0.439168740827727 no 1428 0.44588875326161 2136 144405 SGTC_2049 5262831 67.185 µM 0.134254100374367 0.439893448576177 no 1429 0.446600823585182 2060 763417 SGTC_2970 9090938 41.86 µM 0.134125258340272 0.439945293462333 no 1430 0.446651763415738 2188 17217104 SGTC_672 1441-0018 53.7 µM 0.133550211189852 0.440176699853025 no 1431 0.446879128544459 2059 251141 SGTC_1757 st041620 31.8375 µM 0.133061756183084 0.440373276503013 no 1432 0.44707227014023 2036 5289815 SGTC_1031 k035-0009 16 µM 0.131595562218843 0.440963428136495 no 1433 0.447652097917642 2170 5180959 SGTC_1185 1319-0113 81.3 µM 0.130957617012357 0.441220245824403 no 1434 0.447904417653168 2095 4672763 SGTC_2289 7946404 165.07 µM 0.13021490535371 0.441519270491117 no 1435 0.448198201108834 2089 1246120 YPR165W RHO1 SGTC_762 1165-0429 115 µM 0.129889351483498 0.441650352922284 no 1436 0.448326984600124 2183 5967793 SGTC_2197 6588183 93.1375 µM 0.129482461056885 0.44181419404332 no 1437 0.448487951084218 2128 884136 SGTC_1342 1486-1464 234 µM 0.128438018144646 0.442234801666376 no 1438 0.448901173082361 2148 3253938 SGTC_1972 st070201 17.4 µM 0.128329745341171 0.442278407942718 no 1439 0.448944013168493 2190 2829099 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.126871100729295 0.442865937008894 no 1440 0.449521210025185 2205 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1474 0330-0125 5.35 µM 0.12672845225506 0.442923401310646 no 1441 0.449577662874031 2168 X1474 SGTC_2569 tetrandrine 100 µM 0.126481618314795 0.443022838367958 no 1442 0.449675349323167 1985 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2221 6807166 181.081 µM 0.126385694461414 0.443061482262674 no 1443 0.449713312756452 2166 674925 SGTC_2997 9067075 71.4286 µM 0.124883690592936 0.443666650122005 no 1444 0.450307815151125 2108 27209819 SGTC_2665 lovastatin 100 µM 0.124059038296884 0.443998964263279 no 1445 0.450634265124731 2100 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2269 7935389 174.42 µM 0.123941591771052 0.444046295469167 no 1446 0.450680760672349 2135 97605 SGTC_3023 9089636 49.47 µM 0.123556281217472 0.444201582062539 no 1447 0.450833304843785 2217 17249241 SGTC_827 3253-0474 693 µM 0.122235914723702 0.444733776657386 no 1448 0.451356091937002 2183 5402065 SGTC_1755 st041960 45.185 µM 0.122151215209762 0.444767919546989 no 1449 0.451389630828171 2102 2257073 SGTC_2907 7721985 69.9 µM 0.119486891170292 0.445842132674642 no 1450 0.452444812481386 2066 3267881 SGTC_1557 sumaresinolic acid 42.3 µM 0.118831543462219 0.446106419701415 no 1451 0.452704408834445 2137 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3107 9121808 49.47 µM 0.118242774979014 0.446343877243912 no 1452 0.452937649066743 2199 662681 SGTC_2464 5717415 7.67 µM 0.117973521903814 0.446452476725228 no 1453 0.453044318904299 2124 5285744 SGTC_636 0kpi-0074 126 µM 0.11744454108321 0.446665845467587 no 1454 0.45325389479541 2090 616434 SGTC_1745 st081495 74 µM 0.117331480989825 0.446711451186272 no 1455 0.453298689546569 2118 13842402 YBL026W LSM2 SGTC_2487 5918373 44.05 µM 0.11726880877793 0.446736731950786 no 1456 0.453323520722621 2231 2876279 SGTC_82 0054-0107 293.755 µM 0.117179796428053 0.446772638192218 no 1457 0.453358788362306 2206 3104697 SGTC_843 0310-0051 143 µM 0.116950209675088 0.446865252044332 no 1458 0.453449754772879 2085 2065037 SGTC_2014 4013930 200 µM 0.11667175777283 0.446977581678621 no 1459 0.453560085713721 2220 64556 SGTC_331 k048-0133 24.5 µM 0.116510452472675 0.447042655421069 no 1460 0.453624001320327 2159 6813582 SGTC_2842 9000675 19.48 µM 0.116037276744025 0.447233552070317 no 1461 0.453811499378818 2014 2989072 SGTC_3074 9116018 49.47 µM 0.115526953047087 0.447439449289831 no 1462 0.454013729028505 2147 17027303 SGTC_2645 abamectin 100 µM 0.115432389516145 0.447477603823717 no 1463 0.454051203711427 2165 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1024 4507-0395 26 µM 0.115379898051971 0.44749878331192 no 1464 0.454072005786543 2087 4201836 SGTC_2515 chrysin 20.77 µM 0.115028162523428 0.447640706978652 no 1465 0.454211399866758 2164 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_587 k089-0003 57 µM 0.114772360947577 0.447743925948566 no 1466 0.454312778512897 2215 9659696 SGTC_2699 st077704 54.6 µM 0.114729046512205 0.447761404187512 no 1467 0.454329945077346 2117 645852 SGTC_771 0250-0039 27.3 µM 0.114160863889429 0.447990686592258 no 1468 0.454555137560157 2084 3005115 SGTC_2990 9074105 71.4286 µM 0.114102835725652 0.448014104051372 no 1469 0.454578137161944 2222 6502001 SGTC_2963 9082507 9 µM 0.113854535785281 0.448114308366005 no 1470 0.454676553157392 2147 16459611 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.113684254258172 0.448183029361233 no 1471 0.454744047436284 2205 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3030 9087619 49.47 µM 0.113653845879394 0.448195301519958 no 1472 0.45475610050543 2153 25236973 SGTC_143 4032-1194 15.74 µM 0.112888436348545 0.448504220418919 no 1473 0.455059502090732 2082 1806963 SGTC_488 nitrendipine 139 µM 0.112798563893972 0.448540494948216 no 1474 0.455095128462103 2229 4507 Dihydropyridine L-type calcium channel blocker. SGTC_566 0958-0068 16.5 µM 0.111326157621364 0.449134852039307 no 1475 0.455678856772624 2179 6815365 SGTC_163 TUB2.036 7.546 µM 0.110857316701138 0.44932413016572 no 1476 0.455864746622318 2234 15992207 YJR013W GPI14 SGTC_3218 9131285 49.47 µM 0.110487850328249 0.449473297420431 no 1477 0.456011242454676 2197 17156417 SGTC_1344 1488-0097 29.1 µM 0.110198534374776 0.449590109969271 no 1478 0.456125962297739 2143 747966 SGTC_1100 amiodarone 5.07 µM 0.109998574600092 0.449670847133873 no 1479 0.456205252680057 2244 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2592 piperlongumine 83.33 µM 0.108045194755108 0.45045966659695 no 1480 0.45697992089588 2095 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1479 0549-0158 134 µM 0.10795341194426 0.450496735434274 no 1481 0.457016324019187 2164 5440202 SGTC_2136 5328288 199.296 µM 0.105379540748775 0.451536433874195 no 1482 0.45803732489056 2132 262395 SGTC_3190 9110366 49.47 µM 0.104087420491923 0.45205850321792 no 1483 0.458549986811844 2228 17123768 SGTC_1883 5-benzylidenerhodanine 20 µM 0.103792933148778 0.452177499762874 no 1484 0.458666837354822 2239 1273210 SGTC_1960 st011366 51.8 µM 0.102111128910495 0.452857165794574 no 1485 0.459334233798264 2215 3972846 SGTC_2826 7992541 19.48 µM 0.10113449104301 0.453251917106595 no 1486 0.459721849254271 2247 2985066 SGTC_1393 3470-5649 58.2 µM 0.0999969562338014 0.453711760237199 no 1487 0.460173370953901 2152 4108395 SGTC_1988 st071872 53.4 µM 0.0983999463014341 0.4543574486315 no 1488 0.460807358659718 2250 16414116 SGTC_1059 3448-6867 171 µM 0.0974248391919599 0.454751754411053 no 1489 0.461194509865782 2260 3934407 SGTC_1046 2001-0062 216 µM 0.0953370586492014 0.455596143354267 no 1490 0.462023554075465 2155 739778 SGTC_2020 4017018 200 µM 0.0937508582662948 0.456237805860621 no 1491 0.462653534547355 2161 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1709 st033179 39.1045 µM 0.0920688353437865 0.456918355932459 no 1492 0.463321674524814 2252 573381 SGTC_1487 3970-0795 2.82 µM 0.0919243346666016 0.456976827138371 no 1493 0.463379078524053 2174 3765103 SGTC_1025 k007-0731 70 µM 0.0904659297993922 0.457567012571376 no 1494 0.463958483494297 2186 6256118 SGTC_2933 9026794 32.47 µM 0.0903030876941654 0.457632917140109 no 1495 0.464023183276661 2199 17586027 SGTC_2841 9004761 38.96 µM 0.0899723804795198 0.457766762743914 no 1496 0.464154581487887 2094 2991039 SGTC_3319 9138450 16.7555 µM 0.0896551469383672 0.457895159711283 no 1497 0.464280629947368 2118 2029690 SGTC_2612 dictamnine 15.46 µM 0.0889880669219389 0.458165167709982 no 1498 0.464545696855345 2144 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_623 k072-0108 16.9 µM 0.0884381086141089 0.458387783929277 no 1499 0.464764236823785 2172 5382803 SGTC_586 0957-0265 8.15 µM 0.087758134992225 0.458663046754186 no 1500 0.465034456383917 2255 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_123 0083-0120 66.675 µM 0.0870421443707704 0.458952911186885 no 1501 0.465319006422812 2128 16001701 SGTC_1877 wortmannin 25 µM 0.0866291097920414 0.459120135651458 no 1502 0.465483163303783 2254 312145 A covalent inhibitor of PI 3-kinase. SGTC_663 1486-0733 13.9 µM 0.0864498024006801 0.459192733721533 no 1503 0.465554429244959 2172 722445 YPR165W RHO1 SGTC_854 0422-0053 192 µM 0.0863740919778896 0.459223387805729 no 1504 0.46558452077658 2227 3596728 SGTC_2081 5214970 32.255 µM 0.085283568270449 0.459664952306615 no 1505 0.46601797727822 2246 2063512 SGTC_2330 7979373 200 µM 0.0850629410108832 0.459754292670092 no 1506 0.466105676137517 2162 1863007 SGTC_1512 0259-0544 12.2 µM 0.0840884808289144 0.460148912885634 no 1507 0.466493041586563 2149 18476 SGTC_2105 5350118 200 µM 0.0839024322171567 0.46022426014485 no 1508 0.466567002875962 2179 2133313 SGTC_1021 4476-0760 85.3 µM 0.0837308620891124 0.460293745073139 no 1509 0.46663520944929 2183 746768 SGTC_978 1416-0512 87.4 µM 0.0833621955253583 0.460443057038871 no 1510 0.466781773723522 2173 6814003 SGTC_3307 9126885 69.2785 µM 0.0829601354041974 0.460605899935002 no 1511 0.466941618820589 2201 24824909 SGTC_2321 7390090 138.78 µM 0.0826488265328052 0.460731991185461 no 1512 0.467065388046054 2139 649046 SGTC_3129 9127257 49.47 µM 0.0814302886309054 0.461225580565674 no 1513 0.467549881121371 2055 837894 SGTC_2989 9073649 71.4286 µM 0.0812585614329241 0.461295146390833 no 1514 0.467618164075866 2285 21367202 SGTC_1175 0741-0056 27.6 µM 0.0804275933537627 0.461631784077789 no 1515 0.467948590831598 2241 765927 SGTC_594 1487-1584 10.8 µM 0.0802659418774871 0.4616972747277 no 1516 0.468012872616035 2217 5013332 SGTC_2748 diazoxide 86.69 µM 0.0802252605863997 0.461713756300944 no 1517 0.468029049933373 2234 3019 A potassium channel activatior. SGTC_2157 5649910 96.377 µM 0.079870514774781 0.461857480409863 no 1518 0.468170120344979 2213 2858091 SGTC_1467 k284-1082 293 µM 0.0797247465887523 0.461916539360097 no 1519 0.468228088582287 2281 3334705 SGTC_2664 lyso-paf C-16 73.48 µM 0.0787872499922219 0.462296392353794 no 1520 0.468600922776486 2257 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2112 5488546 200 µM 0.0777954727537211 0.46269827609599 no 1521 0.46899537387779 2261 600757 SGTC_1945 st075991 56.6 µM 0.0766627595820293 0.463157315852892 no 1522 0.469445915433435 2097 1084980 SGTC_1314 1222-0010 41.1 µM 0.0763849927120688 0.463269890290175 no 1523 0.469556404401162 2192 3526027 SGTC_20 0481-0013 4.944 µM 0.076334646491929 0.463290295117215 no 1524 0.46957643116559 2228 182045 SGTC_3219 9131112 49.47 µM 0.0750535977456504 0.463809523901017 no 1525 0.470086033636627 2292 17612988 YMR079W SEC14 SGTC_2018 5133068 143 µM 0.0749134420306153 0.463866334927869 no 1526 0.470141790708756 2263 785362 SGTC_429 1112-0049 25.5 µM 0.0744708103373325 0.464045757067631 no 1527 0.470317883315956 2098 2836170 SGTC_294 k038-0071 157 µM 0.0739710413115448 0.464248348790918 no 1528 0.470516713900224 2198 24152826 SGTC_1643 st009866 20.2 µM 0.073255618676611 0.464538376289898 no 1529 0.470801353964656 2271 3156273 YOR207C RET1 SGTC_1193 1488-0126 41.5 µM 0.0723951876519372 0.46488721415421 no 1530 0.47114370722249 2283 1384710 SGTC_1648 st011736 69.8 µM 0.0723309388755319 0.464913263122531 no 1531 0.471169271754935 2256 2855514 SGTC_598 3937-0236 20.2 µM 0.0722475481283371 0.464947073219152 no 1532 0.471202453038119 2231 1379313 SGTC_3090 9117696 49.47 µM 0.0710898857653443 0.465416463993608 no 1533 0.471663108897495 2260 7923821 SGTC_3122 9126309 49.47 µM 0.0705143350352728 0.465649847224984 no 1534 0.471892145621489 2293 17591206 SGTC_462 ag-879 158 µM 0.0694298765705287 0.466089622292132 no 1535 0.472323724114273 2279 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2101 5377231 179.231 µM 0.0676275993743218 0.46682058216901 no 1536 0.473041042282496 2223 2844213 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0670227357101483 0.467065925392657 no 1537 0.473281801707083 2256 390807 SGTC_2128 5255449 168.493 µM 0.0666440117230484 0.467219548805884 no 1538 0.473432553659136 2272 736008 SGTC_278 4092-0821 23.9 µM 0.0645988865394809 0.468049205387955 no 1539 0.47424668563636 2242 877900 SGTC_3241 9133421 49.47 µM 0.0641821317613343 0.468218289609975 no 1540 0.474412602423034 2281 17018221 SGTC_778 3456-2434 196 µM 0.0635638850128187 0.468469132968761 no 1541 0.474658744573767 2290 5539063 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0633054822165568 0.468573979330588 no 1542 0.474761625172251 2312 4114 Related to psoralen; DNA damaging agent. SGTC_1505 k297-0037 20.6 µM 0.0632862090589787 0.468581799458993 no 1543 0.474769298662881 2222 4089396 SGTC_1297 1068-0111 14.1 µM 0.0627678174225829 0.468792142606532 no 1544 0.474975696646621 2248 767057 SGTC_689 0833-0039 98 µM 0.0624825535115335 0.468907895317318 no 1545 0.475089277535673 2279 5374726 SGTC_64 000l-0018 272.079 µM 0.0623221524587272 0.468972983067443 no 1546 0.475153143826873 2253 6811119 SGTC_1936 st074407 74.3 µM 0.0613598088094874 0.469363501490091 no 1547 0.475536329970395 2300 809813 SGTC_3124 9127567 49.47 µM 0.0613585194168073 0.469364024744652 no 1548 0.47553684339623 2296 17592030 SGTC_2347 9049783 174.81 µM 0.0608504602429193 0.469570206757149 no 1549 0.475739151641619 2255 6467988 YPL169C MEX67 SGTC_3295 9122362 53.5725 µM 0.0607516629682108 0.4696103018963 no 1550 0.475778493265975 2216 4730473 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0605806958515689 0.469679686626368 no 1551 0.47584657388049 2295 688662 SGTC_2091 4-phenylthiadiazole 200 µM 0.0563169224453922 0.471410374731166 no 1552 0.477544669033421 2275 270010 SGTC_920 mycophenolic acid 780.421 nM 0.0562617983436428 0.471432753501181 no 1553 0.477566625556173 2258 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2673 kobusone 100 µM 0.056127807995252 0.471487150032276 no 1554 0.477619995637198 2311 6710676 An epoxy ketone and protein crosslinker. SGTC_949 1165-0505 146 µM 0.0553365291907836 0.471808399072584 no 1555 0.477935180325798 2244 6244267 SGTC_645 0845-0943 5.41 µM 0.0553074971045189 0.471820186077155 no 1556 0.477946744742356 2251 1885106 SGTC_1379 2144-0755 36.5 µM 0.0550229399437531 0.471935717369287 no 1557 0.478060094020973 2290 5392327 SGTC_2742 clothiapine 36.27 µM 0.0549512454174148 0.471964825993129 no 1558 0.478088652791276 2310 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2083 5306046 65.942 µM 0.0538744613172081 0.47240202796924 no 1559 0.478517592012027 2274 539837 SGTC_417 st075190 100 µM 0.0524603963691898 0.472976225050582 no 1560 0.479080925488584 2319 222757 SGTC_3095 9117207 49.47 µM 0.0523809695141608 0.473008478901189 no 1561 0.479112568712714 2306 17015229 SGTC_1692 fluoroquinolonic acid 71 µM 0.0518737325891487 0.473214463071175 no 1562 0.479314652222731 2261 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_247 mechlorethamine 29.705 µM 0.0511729607814105 0.473499051718253 no 1563 0.479593848888545 2292 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1332 1480-0653 17.5 µM 0.0504134983888216 0.473807490317035 no 1564 0.479896439952954 2325 5749438 SGTC_345 1362-0200 395 µM 0.0503223969736762 0.473844490169724 no 1565 0.479932738087118 2240 1419823 SGTC_2472 5377652 49.4 µM 0.0501368718205446 0.473919839897789 no 1566 0.4800066586045 2210 1610903 SGTC_1482 3346-2049 8.48 µM 0.0501086131063066 0.473931317056551 no 1567 0.480017918048023 2311 3826804 SGTC_1797 st048695 56.8 µM 0.0500835656032772 0.473941490013382 no 1568 0.480027898025173 2326 592262 YIL048W NEO1 SGTC_1436 4092-1007 8.32 µM 0.0490803933892077 0.474348938840934 no 1569 0.480427614191407 2312 2881121 SGTC_2237 6667747 47.222 µM 0.0481192102585213 0.474739358542344 no 1570 0.480810618183163 2178 729940 YDL015C TSC13 SGTC_146 3448-8650 53.125 µM 0.0481057254799344 0.474744836052052 no 1571 0.480815991608655 2198 2891488 YIL048W NEO1 SGTC_3047 9092122 49.47 µM 0.0477152815937933 0.474903436211665 no 1572 0.480971577512249 2286 17173831 SGTC_1426 4048-4480 71.7 µM 0.0474880930427127 0.474995723111295 no 1573 0.481062110002859 2322 14224343 SGTC_1695 st026914 34.495 µM 0.0472261300361561 0.475102137505199 no 1574 0.481166500997487 2293 3289191 SGTC_452 diindolylmethane 8 µM 0.0470215853643947 0.475185228706302 no 1575 0.481248011960894 2303 3071 Inhibits expression of several cancer promoting factors. SGTC_2151 5563267 85.4165 µM 0.0457531734467878 0.475700513554763 no 1576 0.48175349093524 2252 5310824 SGTC_473 2-arachidonoylglycerol 10 µM 0.0446853318178973 0.476134349454096 no 1577 0.482179062766524 2270 5282280 An endocannabinoid. SGTC_125 0133-0007 11.75 µM 0.0443521402371341 0.476269722223787 no 1578 0.482311855317763 2319 26541 SGTC_992 3909-8734 162 µM 0.0437782334966575 0.476502901830501 no 1579 0.48254058880002 2306 4288319 SGTC_3205 9113483 49.47 µM 0.0421416426962622 0.477167896293171 no 1580 0.483192891784538 2314 17018033 SGTC_2040 5100729 123 µM 0.0406163335102238 0.477787731082096 no 1581 0.483800881321654 2309 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_987 1497-1013 404 µM 0.040314313027826 0.477910468555514 no 1582 0.483921271454859 2320 1676435 SGTC_1066 ketoconazole 628 nM 0.0398315406204531 0.478106665772839 no 1583 0.484113715199176 2316 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_847 0342-0274 5.54 µM 0.0387098266176354 0.478562547289394 no 1584 0.484560869387427 2322 18097 SGTC_1803 st050068 52.4 µM 0.0380725367113714 0.478821564067884 no 1585 0.484814923979259 2344 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1364 1653-0028 37.6 µM 0.0380068830775615 0.478848248497706 no 1586 0.484841097046321 2292 5718652 SGTC_1091 telmisartan 47.6 µM 0.037830796454647 0.478919818060167 no 1587 0.484911294960351 2304 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1055 3448-0672 86 µM 0.0377891475123456 0.478936746172285 no 1588 0.484927898611885 2296 748378 SGTC_950 1165-0508 94.1 µM 0.0376905358159577 0.478976826809801 no 1589 0.484967210980711 2288 6148369 SGTC_2473 5854593 8.94 µM 0.0372405074057752 0.4791597431553 no 1590 0.485146620379831 2337 2872951 SGTC_2045 5106652 78.05 µM 0.0365680412849253 0.479433078612062 no 1591 0.485414712919326 2329 673349 SGTC_2315 7733312 200 µM 0.0362162389377391 0.479576078607402 no 1592 0.485554968841862 2319 726316 SGTC_277 nystatin 15.5 µM 0.0350540202560492 0.480048513787015 no 1593 0.486018332689401 2340 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_371 0195-0006 7.36 µM 0.0349757042868262 0.480080349791418 no 1594 0.486049557093685 2302 3928593 SGTC_2563 tomatine 8.54 µM 0.0347941403280508 0.480154157334106 no 1595 0.486121946572464 2365 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_259 usnic acid 108.925 µM 0.0347736898493896 0.480162470698369 no 1596 0.486130100198943 2334 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_246 cycloheximide 667 µM 0.0339569985208395 0.480494472509467 no 1597 0.486455720559057 2313 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_941 3237-0776 460 µM 0.0337262023512572 0.480588298358313 no 1598 0.486547742199891 2330 760008 SGTC_103 0844-0104 51.839 µM 0.0326150396203717 0.481040035661255 no 1599 0.486990788164266 2351 5375804 SGTC_531 3788-1495 174 µM 0.0308922130012215 0.481740489598824 no 1600 0.487677750042864 2346 2896655 SGTC_2600 tangeritin 87.95 µM 0.027897554718863 0.482958168216745 no 1601 0.488871929368742 2358 68077 A bioactive flavone. SGTC_2306 7482397 179.52 µM 0.0273801782200992 0.483168558659256 no 1602 0.48907825390526 2350 891448 SGTC_2565 isoliquiritigenin 100 µM 0.0266814820254283 0.483452689934643 no 1603 0.489356891538716 2272 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1368 1852-0141 284 µM 0.026371349018312 0.483578811094317 no 1604 0.489480573185312 2321 2838987 SGTC_3031 9088762 49.47 µM 0.0260910578608128 0.483692797943535 no 1605 0.489592354714783 2366 205253 SGTC_210 3551-0445 56.827 µM 0.0258620515075343 0.483785929636681 no 1606 0.489683684212465 2323 2865180 YOR207C RET1 SGTC_3057 9095946 49.47 µM 0.0256647314722002 0.483866175932194 no 1607 0.489762377396476 2370 24540043 SGTC_1995 st072814 61.1 µM 0.0253910593781694 0.48397747423499 no 1608 0.489871521196558 2333 5769371 SGTC_2952 9073731 13.78 µM 0.0251166362111466 0.48408907924137 no 1609 0.489980965295336 2352 16457353 SGTC_398 bronopol 33.3 µM 0.0247005311722499 0.484258307145231 no 1610 0.490146915698327 2328 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2311 7694451 200 µM 0.0237730394383755 0.484635523700221 no 1611 0.490516822690772 2337 2163142 SGTC_772 k072-0172 35.3 µM 0.0234666618911974 0.484760132358465 no 1612 0.490639015557337 2340 5861980 SGTC_2199 6590217 200 µM 0.0229978577245209 0.484950805402598 no 1613 0.490825990893295 2339 703109 SGTC_2344 7990960 76.95 µM 0.0219990888638535 0.485357038252775 no 1614 0.49122434117212 2341 140813 SGTC_1045 1348-1485 165 µM 0.0206182193818343 0.485918709204663 no 1615 0.491775103295092 2367 6810614 SGTC_1833 st055984 71 µM 0.0204237390481357 0.485997816672871 no 1616 0.491852673388276 2351 676288 SGTC_1410 3909-8106 77.9 µM 0.0203613269991376 0.486023203722711 no 1617 0.491877567016811 2361 1039210 SGTC_1633 st005664 67.9 µM 0.0202643684879809 0.486062643183595 no 1618 0.491916239887077 2366 2063822 SGTC_1916 st067606 49.2 µM 0.0199737497371802 0.486180857930848 no 1619 0.492032156531297 2362 19590279 SGTC_2944 9067346 25.62 µM 0.0197403587069945 0.486275795085565 no 1620 0.492125247726034 2353 6473075 SGTC_1684 st024538 14.6195 µM 0.0181990683591602 0.486902769563846 no 1621 0.492740022927929 2366 6732859 SGTC_3141 9094609 49.47 µM 0.0172020253381766 0.487308369493569 no 1622 0.493137723221416 2358 25236309 YDL196W YDL196W SGTC_1776 st049249 45.9 µM 0.0170270506742397 0.487379551049281 no 1623 0.493207517790349 2359 1822314 SGTC_545 4218-0007 221 µM 0.0159230410223633 0.487828683105486 no 1624 0.493647894126993 2368 2840508 SGTC_919 tnp00227 403.569 nM 0.015157087068985 0.488140296798882 no 1625 0.493953428641827 2363 1269246 A methoxyflavone. YNL221C POP1 SGTC_2715 st079500 56.4 µM 0.014408547351164 0.488444832840714 no 1626 0.49425202014922 2382 28246688 SGTC_3009 9080819 71.4286 µM 0.0143071396129223 0.488486090106442 no 1627 0.494292471813824 2365 17027216 SGTC_1696 st025591 34.7925 µM 0.0116544229285349 0.489565377980004 no 1628 0.495350663190172 2391 2787147 SGTC_2085 5307070 144.047 µM 0.0115635773865081 0.48960234091752 no 1629 0.495386902875787 2381 2840351 SGTC_968 1309-0633 340 µM 0.0100979085027285 0.490198699608431 no 1630 0.495971585816145 2389 3761976 SGTC_904 1141-0088 396 µM 0.0100576549269229 0.490215078500068 no 1631 0.495987643854009 2366 1378119 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.00835194402864665 0.490909134858656 no 1632 0.496668095139625 2365 688788 SGTC_1475 4092-1048 11.7 µM 0.00757115759308601 0.491226847357199 no 1633 0.496979573980922 2381 2881759 SGTC_2345 9052315 157.45 µM 0.00684835416407777 0.491520970756653 no 1634 0.497267923328515 2380 6469265 SGTC_2834 9001755 58.44 µM 0.00682567249380117 0.491530200464521 no 1635 0.497276971794292 2371 2989575 SGTC_271 rotenone 740 µM 0.0063400539560896 0.491727811208188 no 1636 0.497470701361635 2357 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_187 1488-2104 32.728 µM 0.00535783419399636 0.492127507990349 no 1637 0.497862543635081 2386 2852859 SGTC_889 0919-1524 82.7 µM 0.00367555881178228 0.492812098040104 no 1638 0.498533667487505 2391 3905452 SGTC_2766 oltipraz 83.91 µM 0.00354148993795987 0.492866657356048 no 1639 0.498587152881489 2399 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_876 0720-0963 56.8 µM 0.00349959235716675 0.492883707600136 no 1640 0.49860386749433 2397 765861 SGTC_3177 9107506 49.47 µM 0.00328359011555091 0.492971610039564 no 1641 0.49869003942539 2399 8897194 SGTC_1627 st003713 25.6 µM 0.00256037095308427 0.493265927633345 no 1642 0.49897856088931 2398 16195070 YER133W GLC7 SGTC_993 3909-8757 62.7 µM 0.00232462228768677 0.493361867511784 no 1643 0.499072610718727 2399 4288324 YLR208W SEC13 SGTC_3153 9100258 49.47 µM 0.00183056010212321 0.493562931462823 no 1644 0.499269712586307 2399 25236848 SGTC_777 1315-0167 517 µM 0.00122203444341152 0.493810579804646 no 1645 0.499512478913758 2397 4221767 SGTC_1816 st051957 91.6 µM 0.00108823507027574 0.493865031723183 no 1646 0.499565857105141 2400 674121 SGTC_1926 methyl fluorone black 53.6 µM 0 0.494307911552144 no 1647 0.5 2405 72721 Reacts with homocysteine. SGTC_2429 5902844 64.44 µM 0 0.494307911552144 no 1648 0.5 2405 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2480 5767542 37.17 µM 0 0.494307911552144 no 1649 0.5 2405 2867358 SGTC_1686 st019653 115.5 µM -0.000471105299762935 0.494499639831428 no 1650 0.499812056184355 2406 97252 SGTC_2519 cryptotanshinone 88.04 µM -0.000588389884304285 0.494547371974249 no 1651 0.499765266411335 2407 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2488 5268135 45.7 µM -0.000686017400188966 0.494587104199382 no 1652 0.49972631867544 2408 1270356 YLR208W SEC13 SGTC_1671 st016596 74.5 µM -0.00114231850932962 0.49477280929613 no 1653 0.499544280948054 2410 2829167 SGTC_3220 9131269 49.47 µM -0.00142855025183588 0.49488930026525 no 1654 0.499430091098705 2410 17722206 SGTC_569 4130-2812 160 µM -0.00248298842144335 0.495318440574519 no 1655 0.499009431954786 2409 743552 SGTC_1248 0469-0687 58.6 µM -0.00252102212673977 0.495333919818738 no 1656 0.498994258749156 2412 4017482 SGTC_1243 0416-0003 5.65 µM -0.00289898213055003 0.495487745209561 no 1657 0.49884347507792 2409 2141977 SGTC_1398 3558-0053 112 µM -0.0030742170300914 0.495559064034831 no 1658 0.498773566779365 2416 4532369 SGTC_3322 9139058 2.11 µM -0.00341726360516421 0.495698680917355 no 1659 0.498636711717967 2444 4908926 YPR165W RHO1 SGTC_1693 xanthone 101.9 µM -0.00395047629417121 0.495915694744082 no 1660 0.498423992077798 2422 7020 An insecticide. SGTC_1476 4112-3294 3.34 µM -0.00468730972874602 0.496215582762599 no 1661 0.498130040815308 2420 704369 SGTC_305 1682-2595 20.8 µM -0.00527417724417695 0.496454436839357 no 1662 0.49789591745783 2422 226033 SGTC_995 3931-2021 34.6 µM -0.00727728029852411 0.497269705416525 no 1663 0.497096810827516 2420 730143 SGTC_1421 4029-0249 71.4 µM -0.00732359951443097 0.49728855761568 no 1664 0.497078332626315 2421 2894095 SGTC_2890 9046729 58.44 µM -0.00739235343965666 0.497316540887465 no 1665 0.49705090452109 2428 903329 SGTC_1060 3448-7350 82 µM -0.00741488531411037 0.497325711502271 no 1666 0.497041915850068 2417 570178 SGTC_883 0850-0245 24.6 µM -0.00909861461772884 0.498011003594261 no 1667 0.496370228017629 2480 6823229 YPR165W RHO1 SGTC_3104 9120930 49.47 µM -0.00918837739231531 0.498047537986739 no 1668 0.496334419348549 2436 17014836 SGTC_2938 9059746 27.26 µM -0.00929518016389041 0.498091007858353 no 1669 0.496291813026876 2427 6471769 SGTC_797 k781-0471 270 µM -0.00993369204633137 0.498350889486268 no 1670 0.496037095417745 2456 23738129 SGTC_2785 7756463 72.73 µM -0.0100902765905123 0.498414621295024 no 1671 0.4959746303535 2427 2201551 SGTC_712 r015-0009 80.6 µM -0.0108988890514648 0.498743736982632 no 1672 0.495652058427077 2427 6813872 YLR060W FRS1 SGTC_3117 9124945 49.47 µM -0.0121373507910505 0.499247808444277 no 1673 0.495158016480708 2423 17592065 SGTC_2812 7970281 58.44 µM -0.0126325290205491 0.49944935337533 no 1674 0.494960484100649 2434 2233435 SGTC_977 1348-1378 135 µM -0.0133654015417857 0.499747643674059 no 1675 0.494668134972938 2431 X977 SGTC_2252 omeprazole 400 µM -0.0136785667736257 0.499875106754602 no 1676 0.494543211542991 2481 4594 A proton pump inhibitor. SGTC_2011 4012611 177 µM -0.0137980917420231 0.499923755264715 no 1677 0.494495532479288 2432 2049887 SGTC_2894 9048625 32.47 µM -0.0138405603596302 0.499941040648998 no 1678 0.494478591569847 2426 4092861 SGTC_2886 9058944 51.95 µM -0.014130275886225 0.499941040648998 no 1679 0.494363023100086 2427 4949929 SGTC_3310 9130229 44.1445 µM -0.0151274721266681 0.49953516645331 no 1680 0.493965241940043 2480 7761258 SGTC_2655 perillic acid 100 µM -0.0157271805236758 0.499291076123659 no 1681 0.493726021377377 2435 5702197 An apoptosis inducer. SGTC_161 4065-0411 162.148 µM -0.0160595596920191 0.499155792915799 no 1682 0.493593438020894 2444 1906281 YLR208W SEC13 SGTC_519 k048-0011 62.8 µM -0.0161138112197273 0.499133711755268 no 1683 0.493571797592969 2491 6836379 SGTC_1651 st011928 86.1 µM -0.0167249023284947 0.49888498898874 no 1684 0.493328040376409 2455 720198 SGTC_582 0987-0078 156 µM -0.0167743561868911 0.49886486058316 no 1685 0.493308313908693 2438 1625765 SGTC_2873 9040596 71.43 µM -0.0171515754916152 0.498711327198351 no 1686 0.493157846829369 2499 6463863 SGTC_2741 miltefosine 3.04 µM -0.0173450698345284 0.498632572443121 no 1687 0.493080665236877 2441 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3196 9111891 49.47 µM -0.0174833111179197 0.498576306445925 no 1688 0.49302552330572 2431 18891510 SGTC_2951 9072950 58.06 µM -0.0178301116608844 0.498435154249367 no 1689 0.492887191471768 2432 16488155 SGTC_684 1140-0066 328 µM -0.0183612675549203 0.498218967484772 no 1690 0.49267532562164 2442 6813534 SGTC_2142 5622915 118.518 µM -0.0184737357764772 0.498173191646249 no 1691 0.492630464902005 2449 5322196 SGTC_1767 st044992 70.3 µM -0.0187250901965662 0.498070887641549 no 1692 0.492530206339861 2451 9600693 SGTC_410 α-linolenic acid 100 µM -0.0188110996574227 0.498035880876809 no 1693 0.492495899572085 2514 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1917 st066507 28.5 µM -0.0189796715089272 0.49796727038566 no 1694 0.492428661137642 2418 3156428 SGTC_1875 nocodazole 6 µM -0.0197436559787224 0.497656321569884 no 1695 0.492123932561247 2440 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2844 9010103 25.97 µM -0.0200118064759262 0.497547182140554 no 1696 0.492016977123151 2491 2480525 SGTC_3027 9089541 49.47 µM -0.0207561965770895 0.497244210313581 no 1697 0.491720070135489 2469 9943819 SGTC_3294 9122953 26.2835 µM -0.0222671344225977 0.496629253420073 no 1698 0.491117432655075 2449 16459826 SGTC_2634 4'-methoxyflavone 100 µM -0.0223159217244901 0.496609396946241 no 1699 0.491097974172785 2456 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2258 7960471 200 µM -0.0240198361953705 0.495915907909835 no 1700 0.490418393137596 2486 2974708 SGTC_3093 9117344 49.47 µM -0.0241870715343278 0.495847844165665 no 1701 0.490351695267948 2563 24824913 SGTC_661 1304-0007 33.6 µM -0.0251562444645281 0.4954533992454 no 1702 0.489965168879607 2465 3117130 SGTC_2506 ethyl hematommate 54.16 µM -0.02539470241583 0.495356349607834 no 1703 0.489870068303293 2491 3940691 An allergen. SGTC_3049 9092223 49.47 µM -0.0263934361904203 0.494949879525973 no 1704 0.489471764744509 2498 8623917 SGTC_836 0330-0104 1.35 µM -0.0263945397614444 0.494949430391481 no 1705 0.489471324636694 2451 46494820 SGTC_2186 6124449 200 µM -0.0264325197103893 0.494933973207149 no 1706 0.489456178113847 2468 3834182 YLR033W RSC58 SGTC_724 3910-0327 137 µM -0.0264496906796643 0.494926984921228 no 1707 0.489449330282395 2462 2885483 SGTC_530 4358-1714 28 µM -0.0266974837869576 0.494826137609671 no 1708 0.48935051003275 2529 1564641 SGTC_1358 1509-0022 2.48 µM -0.0274885393428991 0.494504194554513 no 1709 0.489035040337122 2480 3258434 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0287317162360257 0.493998254891181 no 1710 0.488539280452641 2485 6710655 SGTC_334 1502-1024 68.5 µM -0.0287804055430397 0.493978439839842 no 1711 0.488519864258864 2524 3296216 SGTC_1631 benzylvanillin 81.9 µM -0.029661821909811 0.493619733088781 no 1712 0.488168380108431 2512 75506 SGTC_1098 clofazimine 15.1 µM -0.0303433459161907 0.493342379312218 no 1713 0.487896613715909 2522 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_515 4092-1064 102 µM -0.0305852905796697 0.493243918006858 no 1714 0.487800136539766 2467 717353 SGTC_3249 9135183 49.47 µM -0.0328509392864128 0.492321915029364 no 1715 0.486896728217467 2569 4902779 SGTC_2407 paclitaxel 400 µM -0.0328902922798626 0.492305900724858 no 1716 0.486881037123746 2690 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1500 4488-1866 171 µM -0.0331426228991208 0.492203217615434 no 1717 0.486780426623371 2472 2900003 SGTC_2496 diffractaic acid 79.83 µM -0.0332131972173864 0.492174498282007 no 1718 0.486752287035832 2462 94870 An apoptosis inducer which activates caspases. SGTC_1253 0550-0034 176 µM -0.0333260950062143 0.492128556027616 no 1719 0.486707272254165 2505 5969915 SGTC_2339 9000433 200 µM -0.0343479124756624 0.491712745815317 no 1720 0.486299859379459 2496 2988954 SGTC_2162 5663267 200 µM -0.034369452657086 0.49170398052184 no 1721 0.486291271161136 2474 6456493 SGTC_3336 9143619 71.43 µM -0.0348458580243779 0.491510119079676 no 1722 0.486101326700646 2462 45595730 SGTC_3048 9093155 49.47 µM -0.0364581422854352 0.490854054817406 no 1723 0.485458527060403 2467 25236002 SGTC_3225 9130819 49.47 µM -0.0365114538547642 0.490832361899684 no 1724 0.485437272972163 2476 4547121 SGTC_2326 6164455 177.58 µM -0.038046258873626 0.490207848947837 no 1725 0.484825399729869 2508 2888790 SGTC_945 3381-0768 11.3 µM -0.0381006786197063 0.490185705956786 no 1726 0.484803705122104 2478 1126236 YIL048W NEO1 SGTC_3001 9076041 71.4286 µM -0.0382915423765727 0.490108045149272 no 1727 0.484727617024152 2487 16004211 SGTC_732 3970-1727 52.7 µM -0.0382948137905454 0.490106714042557 no 1728 0.484726312875333 2483 1275699 SGTC_1838 st055369 84.5 µM -0.039075930829491 0.489788888259391 no 1729 0.484414925362405 2464 676036 SGTC_2596 sinensetin 100 µM -0.0391737026259825 0.489749106712131 no 1730 0.484375949901257 2494 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_276 colchicine 750 µM -0.0392714668438037 0.489709328350456 no 1731 0.484336977610509 2548 2833 A microtubule depolymerizer. SGTC_2316 5844804 197.44 µM -0.0393716419105297 0.489668569167356 no 1732 0.484297044424942 2488 776813 SGTC_1590 st077108 57.8 µM -0.0397793542694866 0.489502680475951 no 1733 0.484134518053716 2455 5489485 SGTC_1454 4239-0054 42.6 µM -0.039787125921847 0.489499518388616 no 1734 0.484131420065574 2597 1340767 SGTC_192 3455-0609 60.9 µM -0.040371210960167 0.489261870970966 no 1735 0.48389859092821 2545 3769639 SGTC_1750 st081859 2.357 µM -0.0406743600906856 0.489138529798574 no 1736 0.483777751179226 2484 5291695 SGTC_2709 st078560 56 µM -0.0422066696929739 0.488515100761505 no 1737 0.483166972826939 2493 17250903 SGTC_451 chloral hydrate 100 µM -0.0425879566925451 0.488359976237976 no 1738 0.483014997974005 2543 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2854 9024559 71.43 µM -0.0426297578010765 0.488342969793031 no 1739 0.482998336875547 2516 3163529 SGTC_2124 5246320 200 µM -0.0430013788603149 0.488191779688122 no 1740 0.482850217350169 2537 579342 SGTC_52 0329-0193 875 nM -0.0431998589948127 0.48811103083447 no 1741 0.482771108745541 2624 3739292 SGTC_1155 4088-0394 48.2 µM -0.0436128920085275 0.487942995723004 no 1742 0.482606487569893 2477 2326248 SGTC_1527 coumarin 137 µM -0.0444140389931477 0.48761706949663 no 1743 0.482287185596791 2651 323 A hepatotoxic, DNA x-linker. SGTC_856 0433-0016 11.3 µM -0.0450927838011511 0.487340945937949 no 1744 0.482016676633001 2537 3911780 SGTC_2575 plumbagin 510 nM -0.0462170130977595 0.486883606027213 no 1745 0.481568641236404 2477 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_565 1418-0001 44.5 µM -0.047171586853087 0.486495296026037 no 1746 0.481188236355551 2537 2862145 SGTC_41 0478-0632 82.643 µM -0.0474545274055979 0.486380201395338 no 1747 0.48107548567497 2470 3750424 SGTC_2187 6125751 200 µM -0.048526070910374 0.485944329017514 no 1748 0.480648493665232 2522 874498 SGTC_1672 st016598 6.51 µM -0.0497280659367263 0.485455412805558 no 1749 0.480169545369447 2556 4665860 YNL267W PIK1 SGTC_666 0272-0154 136 µM -0.0503331594734344 0.48520929685325 no 1750 0.479928449905098 2515 6870312 SGTC_2439 5492030 7.2 µM -0.0507259106863602 0.485049552099939 no 1751 0.479771964740773 2519 5722370 SGTC_1157 4092-0394 27.6 µM -0.0510660206893179 0.48491122018459 no 1752 0.479636456105706 2621 3659885 SGTC_1170 0310-0127 64.8 µM -0.0521198054253791 0.484482629101384 no 1753 0.479216615982692 2543 774975 SGTC_1810 st050138 53 µM -0.0525455331736448 0.484309483882755 no 1754 0.479047007598282 2498 3444541 SGTC_150 3970-0969 77.2 µM -0.0541703730388913 0.483648682330843 no 1755 0.478399712452097 2635 6615640 SGTC_3003 9075612 71.4286 µM -0.0552028460464596 0.483228812009384 no 1756 0.477988430788945 2562 6501993 SGTC_1374 2889-5571 141 µM -0.0559194293259612 0.482937413793453 no 1757 0.477702996341394 2562 2853281 SGTC_1206 3978-0017 132 µM -0.0563696463758755 0.482754337917633 no 1758 0.47752366858848 2721 3873677 SGTC_901 1112-0062 60.1 µM -0.0567329947250032 0.482606588905668 no 1759 0.477378945171908 2485 1908457 SGTC_2523 spermine 47.74 µM -0.056794842443796 0.482581439890603 no 1760 0.477354311220975 2524 1103 A DNA binding polyamine. SGTC_1346 1488-2224 62.4 µM -0.0569307067395474 0.482526193905341 no 1761 0.477300196765968 2483 3722427 SGTC_100 0086-0128 49.5915 µM -0.0576567388696776 0.482230975916463 no 1762 0.477011026858697 2505 93297 SGTC_493 zm226600 134 µM -0.0578156659547599 0.482166354541065 no 1763 0.476947729712532 2619 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1389 3405-0187 19 µM -0.0580544523127024 0.482069262451363 no 1764 0.476852627476545 2541 799890 SGTC_1266 0828-0227 32.9 µM -0.059248767519218 0.481583662179685 no 1765 0.4763769834871 2565 3913820 SGTC_3302 9125395 16.351 µM -0.0601832372717544 0.48120373228228 no 1766 0.476004848115993 2542 17599668 SGTC_1188 1403-0014 4.57 µM -0.0608116494493363 0.480948246621103 no 1767 0.475754606287327 2530 9614867 SGTC_1491 4138-0063 26.5 µM -0.0635017159652736 0.479854669741709 no 1768 0.474683496430513 2514 23883227 SGTC_1899 st063254 59.6 µM -0.0638210601462039 0.479724858541891 no 1769 0.474556354435273 2509 3093813 SGTC_745 0469-0705 296 µM -0.0645090570393967 0.479445199890186 no 1770 0.474282447829896 2549 3486736 SGTC_2751 anetholtrithion 17.25 µM -0.0646037939112406 0.479406691805402 no 1771 0.474244731959208 2575 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1096 rimcazole 32.2 µM -0.064647396105657 0.479388968707206 no 1772 0.474227373486761 2507 18528119 A dopamine reuptake inhibitor. SGTC_996 3970-0799 1.8 µM -0.0650372901746631 0.479230489259042 no 1773 0.474072154912508 2502 6615648 YGL040C HEM2 SGTC_1795 st049545 62.3 µM -0.0671679379487795 0.478364507852663 no 1774 0.47322400463643 2524 5291882 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0683571766103306 0.477881197325833 no 1775 0.472750655083922 2567 4213774 SGTC_2403 6032726 181.2 µM -0.0687191772065904 0.477734085510799 no 1776 0.472606576542206 2567 2881040 SGTC_1036 k216-0215 33.5 µM -0.070304365212299 0.47708992399207 no 1777 0.471975704084856 2524 622330 SGTC_2474 5321570 43.32 µM -0.0711762045128699 0.476735666293455 no 1778 0.471628759711445 2671 2841384 SGTC_3135 9127742 49.47 µM -0.0713596585991629 0.476661125045735 no 1779 0.471555757748415 2615 3643468 SGTC_2184 6075246 200 µM -0.071492063953889 0.476607326476908 no 1780 0.471503070222613 2575 2267320 SGTC_3226 9131256 49.47 µM -0.0717683696551778 0.476495060101142 no 1781 0.471393122622929 2516 17178073 SGTC_2926 9010726 65.15 µM -0.0723115298539331 0.476274372935907 no 1782 0.471176994611177 2607 2994293 SGTC_1077 5-fluorocytosine 377 nM -0.0726544415185891 0.476135050926922 no 1783 0.4710405515427 2611 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_218 alverine citrate 93.75 µM -0.0730198488170518 0.475986592350006 no 1784 0.47089516130032 2626 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1494 4358-1428 177 µM -0.0736860174909498 0.475715948293459 no 1785 0.470630112483194 2533 1564571 SGTC_416 estradiol valerate 100 µM -0.0739712514365604 0.475600069841021 no 1786 0.470516630301499 2571 13791 A steroid. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0745454239983216 0.475366814154006 no 1787 0.470288199281216 2784 5282309 SGTC_1723 st034307 2.5525 µM -0.0750833234440278 0.475148301956837 no 1788 0.470074208165599 2589 867466 SGTC_1308 1187-1617 41.4 µM -0.0752718352846451 0.475071724099827 no 1789 0.469999215039977 2527 2882570 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0767449558838035 0.474473340476377 no 1790 0.469413220175959 2586 75037 A free radical scavenger. SGTC_1738 st035555 74 µM -0.0769824185858735 0.474376888152407 no 1791 0.469318765696606 2616 5331140 SGTC_2566 crystal violet carbinol 226 nM -0.0782970089234283 0.473842956704011 no 1792 0.468795898346951 2685 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1183 1254-0324 198 µM -0.078830719842349 0.473626199073337 no 1793 0.468583634586028 2631 5799357 SGTC_3058 9093861 49.47 µM -0.079055318392374 0.473534984515158 no 1794 0.468494311493352 2607 17217477 SGTC_2851 9015922 71.43 µM -0.0791922925374669 0.4734793568933 no 1795 0.468439837502059 2616 2996893 SGTC_2317 5986382 200 µM -0.0793109338881319 0.473431174961285 no 1796 0.468392654856816 2583 877883 SGTC_3137 9097352 49.47 µM -0.0800115452013557 0.473146654737364 no 1797 0.4681140368344 2663 44120435 SGTC_393 acivicin 6.25 µM -0.0812398241880593 0.472647880336607 no 1798 0.467625614522624 2573 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2934 9036370 36.88 µM -0.0815482325975989 0.472522649843082 no 1799 0.467502984254462 2618 6462800 SGTC_1725 st036284 20.55 µM -0.0816525603268279 0.472480287756973 no 1800 0.467461501850311 2615 707914 SGTC_1176 0848-0131 83.3 µM -0.0819533538766842 0.472358152823286 no 1801 0.467341903416081 2614 6769040 SGTC_1114 scopoletin 1.73284 µM -0.0836727764444296 0.471660044600629 no 1802 0.466658301236522 2544 5280460 A coumarin with genotoxic properties. SGTC_474 dl-dihydrosphingosine 5 µM -0.0841506664322997 0.471466030337862 no 1803 0.466468320738681 2700 3058739 A sphingolipid protein kinase C inhibitor. SGTC_215 1287-0124 461.5 µM -0.0848602003636945 0.471177985535492 no 1804 0.466186266558252 2635 5560863 SGTC_14 0354-0009 295 µM -0.0856043742333871 0.47087589438794 no 1805 0.465890460545888 2538 1713507 SGTC_2214 7179297 48.276 µM -0.0894136395124758 0.469329821227041 no 1806 0.46437659206276 2558 769744 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0896335931992776 0.46924056213514 no 1807 0.464289194164456 2573 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1313 1220-0047 237 µM -0.0899634999396802 0.469106686051009 no 1808 0.464158110001465 2605 3528706 SGTC_1216 1165-0504 9.65 µM -0.090140107559117 0.469035020151538 no 1809 0.464087938853125 2574 6304004 SGTC_3071 9117417 49.47 µM -0.0905556936291098 0.46886638275163 no 1810 0.463922819291248 2635 45595590 YGL055W OLE1 SGTC_2657 nystatin 74.44 µM -0.0916258273869001 0.468432167380243 no 1811 0.463497665237321 2619 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2976 9009005 19.48 µM -0.0923270519849985 0.468147660197146 no 1812 0.46321909789155 2585 2993148 SGTC_2531 methyl deoxycholate 70.07 µM -0.0929931066726499 0.46787743753033 no 1813 0.462954518785553 2590 16667744 Haematoxylin. SGTC_3112 9123419 49.47 µM -0.0933385923537431 0.467737277591411 no 1814 0.462817286813247 2565 17015854 SGTC_1924 st058459 75.1 µM -0.0934491108153527 0.467692442247291 no 1815 0.46277338819516 2562 688683 SGTC_1493 4348-0038 111 µM -0.0934644132977201 0.467686234338818 no 1816 0.462767309990021 2577 800424 SGTC_2875 9039966 71.43 µM -0.0937068154618573 0.467587897718892 no 1817 0.462671028074034 2667 6463691 SGTC_1338 1486-1223 76 µM -0.0937315864094215 0.467577848863564 no 1818 0.46266118919958 2646 3444526 SGTC_2051 5263410 176 µM -0.0942364515209358 0.467373044234653 no 1819 0.462460664737229 2553 227584 SGTC_2089 5281248 129.67 µM -0.0944759858012775 0.467275877279068 no 1820 0.462365528831493 2578 2737878 SGTC_3210 9128157 49.47 µM -0.094879873936462 0.467112044687093 no 1821 0.462205121331665 2723 17590849 SGTC_1495 4469-0029 237 µM -0.0957350301727654 0.466765178783981 no 1822 0.461865509305633 2572 793680 SGTC_1126 isoteolin 1.0172 µM -0.0966418922119764 0.466397367708834 no 1823 0.461505393502661 2589 133323 SGTC_2287 7945887 168.79 µM -0.0970731207564877 0.46622247724527 no 1824 0.461334163279362 2628 1245853 SGTC_1742 st038235 28.8875 µM -0.0975668234375524 0.466022257576054 no 1825 0.461138134919085 2681 564103 YBR002C RER2 SGTC_1766 st045414 44.774 µM -0.0979624237765498 0.465861829226628 no 1826 0.460981065643123 2579 253960 SGTC_1015 4130-4525 82 µM -0.0982874125357083 0.465730040237654 no 1827 0.460852036562882 2596 1363237 SGTC_1575 cyproterone acetate 48 µM -0.100523489088102 0.464823372240249 no 1828 0.459964367844328 2608 9880 An androgen receptor antagonist and liver toxin. SGTC_1856 st057054 55.7 µM -0.101512758534098 0.4644223084715 no 1829 0.459571715015931 2761 1266018 SGTC_290 2043-6722 48.1 µM -0.102037997649113 0.464209383799798 no 1830 0.45936325735455 2629 773758 YLR208W SEC13 SGTC_24 0417-1663 219 µM -0.102251853061761 0.464122692706541 no 1831 0.459278385305518 2643 4329390 SGTC_1160 4092-0570 10.5 µM -0.10324726815417 0.463719201329512 no 1832 0.458883362887287 2591 4994975 SGTC_2639 lactacystin 53 µM -0.103299409519665 0.463698066858769 no 1833 0.458862672124208 2660 3870 A proteasome inhibitor. SGTC_1736 st036774 51 µM -0.105407611421953 0.462843635396362 no 1834 0.458026188335612 2844 1272247 SGTC_760 0568-0725 82.9 µM -0.105433210130891 0.462833261561382 no 1835 0.458016032518525 2712 3916171 SGTC_1305 1181-0477 144 µM -0.106113639454636 0.462557527976909 no 1836 0.457746094763245 2706 6252086 SGTC_2953 9074162 66.49 µM -0.106364003176873 0.462456076425527 no 1837 0.457646776162705 2624 16451992 SGTC_63 0099-0242 26.702 µM -0.106441164555529 0.462424809841405 no 1838 0.457616166988734 2588 3898502 YLR359W ADE13 SGTC_132 0417-1715 25.805 µM -0.106610120503825 0.462356347964734 no 1839 0.457549144673353 2621 6769098 SGTC_69 0096-0274 206.684 µM -0.107990571653704 0.461797023548895 no 1840 0.457001585600715 2889 6741392 SGTC_599 1935-0052 86.5 µM -0.108857071822384 0.461445977789456 no 1841 0.456657927978619 2605 9557311 SGTC_1938 st074717 56.4 µM -0.108881655034189 0.46143601881425 no 1842 0.456648178644759 2560 17250979 SGTC_2336 9001819 198.65 µM -0.110318437860408 0.460854001832192 no 1843 0.456078417606728 2737 2989602 SGTC_1419 3993-2473 62.6 µM -0.110351754594414 0.460840506763623 no 1844 0.456065206811133 2617 704026 SGTC_418 lividomycin a 100 µM -0.110839283636011 0.460643036455918 no 1845 0.455871896711418 2608 72394 An antibiotic. SGTC_1108 betulinic acid 729.144 nM -0.11095950132896 0.460594344590461 no 1846 0.455824230807691 2615 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_687 k029-0044 34.9 µM -0.111551193896348 0.460354699515201 no 1847 0.455589636009153 2625 5829338 SGTC_2659 sanguinarine 24.21 µM -0.111748440767191 0.460274814533063 no 1848 0.455511434830476 2599 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3278 9139605 49.47 µM -0.111963291127694 0.460187801962224 no 1849 0.455426256472631 2816 7958859 SGTC_2676 harmalol 100 µM -0.112067763074507 0.460145492399925 no 1850 0.455384838856075 2603 5459187 A monoamine oxidase inhibitor SGTC_2471 5466956 24.79 µM -0.112203613861181 0.460090475555889 no 1851 0.455330981909907 2657 724419 SGTC_2425 5628681 7.85 µM -0.112619953668318 0.459921871047591 no 1852 0.455165932476406 2679 5714958 SGTC_1520 flindersine 88 µM -0.113739708802724 0.459468441327986 no 1853 0.45472206684329 2885 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1315 1237-0019 3.69 µM -0.115713740904801 0.458669212433405 no 1854 0.453939707871694 2660 825140 SGTC_2367 9070478 135.38 µM -0.115867819595306 0.458606837383871 no 1855 0.453878650059109 2620 572802 SGTC_753 1322-0200 289 µM -0.118161975005291 0.457678225178289 no 1856 0.45296965919005 2745 5403907 SGTC_3050 9093513 49.47 µM -0.118683775297308 0.457467046561849 no 1857 0.452762945561337 2638 25236664 SGTC_36 0335-0881 14.2 µM -0.120881453616774 0.456577753203213 no 1858 0.451892466153073 2608 23828853 SGTC_2359 9039622 200 µM -0.121450712035159 0.456347437328507 no 1859 0.4516670258625 2641 6463596 SGTC_2132 5317594 122.667 µM -0.121775309435782 0.456216115248235 no 1860 0.451538484306199 2634 794577 SGTC_313 3474-0040 5.03 µM -0.12333060433731 0.45558695758538 no 1861 0.450922653532472 2611 1043375 YIL048W NEO1 SGTC_2276 7947513 42.08 µM -0.124716937919528 0.455026243040771 no 1862 0.45037382378987 2714 2105100 SGTC_937 3122-0005 46.7 µM -0.12500489459162 0.454909787687374 no 1863 0.450259837706655 2732 759535 SGTC_1921 5740136 50 µM -0.125805530880145 0.454586014989454 no 1864 0.449942931776667 2602 1774243 SGTC_1384 3089-0840 101 µM -0.126041684252707 0.454490521679723 no 1865 0.449849464203536 2651 1069836 SGTC_1545 lovastatin 49.4 µM -0.126249715916972 0.454406402120565 no 1866 0.449767129277169 2671 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1947 st076332 61.6 µM -0.127144369199714 0.454044664008668 no 1867 0.449413067427902 2695 24208416 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.1271500960459 0.454042348576526 no 1868 0.449410801139942 2630 17037758 SGTC_1343 1487-0095 224 µM -0.128101296507206 0.45365778863159 no 1869 0.449034405019412 2633 4560101 YGL055W OLE1 SGTC_2614 arthonioic acid 13.39 µM -0.128155169328484 0.453636009735724 no 1870 0.449013088567774 2625 6710684 SGTC_563 tetrahydrosecaminediol 614 µM -0.129308099769344 0.453169953843299 no 1871 0.448556931277395 2745 334274 A psychoactive constituent of the cannabis plant. SGTC_2670 beta-carotene 100 µM -0.129897500859684 0.452931721627251 no 1872 0.44832376078107 2646 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2843 9000894 45.46 µM -0.131249220861071 0.452385429012697 no 1873 0.44778908003831 2612 2242070 SGTC_359 0081-0058 15.9 µM -0.131463501883371 0.452298836383468 no 1874 0.447704328613339 2970 3494159 SGTC_2307 7538926 6.34 µM -0.131741358757014 0.452186555636924 no 1875 0.447594435521382 2701 96582 SGTC_3347 9188721 44.724 µM -0.133996042963718 0.451275589804619 no 1876 0.44670285173754 2731 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1034 k072-0165 12.7 µM -0.134182767799231 0.451200158328627 no 1877 0.446629025990519 2763 5835461 SGTC_1882 5615643 20 µM -0.134681737299194 0.450998597620602 no 1878 0.446431756569672 2614 2253075 SGTC_2816 7982706 58.44 µM -0.134731604596357 0.450978454221784 no 1879 0.446412042078782 2747 2981853 SGTC_1683 st010134 710 nM -0.135058256852577 0.450846509415409 no 1880 0.446282906957279 2629 3818134 SGTC_1506 4226-2149 212 µM -0.137699180790151 0.449779960431055 no 1881 0.445239083433748 2739 991114 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.137947564079267 0.44967966826431 no 1882 0.44514092951 2651 6708561 SGTC_1891 st059073 26.2 µM -0.138074256362861 0.449628513710737 no 1883 0.445090865662392 2803 688754 SGTC_3228 9131799 49.47 µM -0.13813742149109 0.44960300983447 no 1884 0.445065905595197 2696 17015818 SGTC_1079 idarubicin 2.36 µM -0.138984496452264 0.449261010659024 no 1885 0.44473120008857 2653 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_65 0798-0905 34.986 µM -0.139273214737413 0.449144451753143 no 1886 0.444617127559616 3021 3602145 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.139531747933487 0.449040082640327 no 1887 0.444514985044824 2712 279621 SGTC_2750 bromebric acid 70.15 µM -0.139975428621231 0.448860978235887 no 1888 0.444339702176746 2764 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2601 securinine 100 µM -0.14035435789188 0.448708020842823 no 1889 0.444190008967352 2691 442872 A GABA receptor antagonist. SGTC_824 1304-0008 100 µM -0.143108780889762 0.447596409677875 no 1890 0.443102135089459 2683 768245 SGTC_1151 3909-8316 15.3 µM -0.144346284922002 0.44709711971383 no 1891 0.442613515449086 2773 800431 SGTC_3144 9087057 49.47 µM -0.147820096174509 0.445696007807945 no 1892 0.441242374558242 2630 17249618 SGTC_541 4513-1321 94 µM -0.148237463466936 0.445527713974952 no 1893 0.441077683419853 2694 747515 SGTC_1250 0485-0349 40.2 µM -0.14889831657363 0.445261260131952 no 1894 0.440816934793376 2708 6842794 YDL195W SEC31 SGTC_1217 1183-1422 255 µM -0.149283935972433 0.445105791049156 no 1895 0.440664795234768 2789 2849664 SGTC_386 1509-0011 3.07 µM -0.149491756304359 0.445022008213062 no 1896 0.44058280689671 2673 3107280 SGTC_2446 5162541 200 µM -0.15139957778554 0.444252984572629 no 1897 0.439830261251016 2663 1549321 SGTC_1603 st002045 67.8 µM -0.151501120201448 0.444212059702358 no 1898 0.43979021362228 2693 5887985 SGTC_3293 9120939 62.045 µM -0.151965806983849 0.444024783530175 no 1899 0.43960695222604 2809 934087 SGTC_1642 st009582 77.7 µM -0.151991178290269 0.444014558849166 no 1900 0.43959694675945 2754 6739311 SGTC_114 0364-0001 490.298 µM -0.152498335517259 0.443810181423008 no 1901 0.439396951574452 2720 4003655 SGTC_682 0kpi-0099 17 µM -0.152696657830517 0.443730264304593 no 1902 0.439318748260925 2781 1714895 YML126C ERG13 SGTC_2273 7815444 169.05 µM -0.153317183792768 0.443480228332141 no 1903 0.439074075086797 2837 2824616 SGTC_1010 4112-3296 15.2 µM -0.155399081602513 0.44264150921058 no 1904 0.438253354072885 2833 704384 SGTC_1405 3909-7894 12 µM -0.156130307813109 0.442346986183659 no 1905 0.437965154560827 2784 7104060 SGTC_1109 tnp00067 928.257 nM -0.156617438299186 0.442150797617332 no 1906 0.437773179189624 2699 676295 SGTC_13 0199-0087 65 µM -0.156752008179171 0.442096602991453 no 1907 0.437720148540449 2675 4589825 SGTC_1820 st053765 18.6 µM -0.159248357971508 0.441091458644292 no 1908 0.436736602897421 2750 3690829 SGTC_1212 0520-0165 585 µM -0.159911354632359 0.440824569419916 no 1909 0.436475451961837 3091 5403258 SGTC_2652 actinonin 100 µM -0.160635371868777 0.440533147074058 no 1910 0.436190296968322 2661 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_400 oxethazaine 37.5 µM -0.161215553416456 0.440299642903921 no 1911 0.435961815748345 2752 4621 A local anesthetic. SGTC_115 0527-0192 112.043 µM -0.161670488942646 0.440116560694544 no 1912 0.435782672592043 2757 4233931 SGTC_2041 5107442 45.335 µM -0.16206175360179 0.439959112142207 no 1913 0.435628612097253 2794 793005 SGTC_1456 k015-0012 13 µM -0.162482586349448 0.439789775713792 no 1914 0.435462920069323 2680 2989616 SGTC_79 0052-0007 94.094 µM -0.16345256148651 0.439399515092256 no 1915 0.435081060602571 2857 2801472 SGTC_1546 5-methoxyflavanone 78.7 µM -0.163821024543867 0.439251282765923 no 1916 0.434936020044162 2766 147795 SGTC_156 3474-0145 5.642 µM -0.165259123970661 0.438672818468786 no 1917 0.43437001536613 2643 2265471 SGTC_2693 st077581 40.7 µM -0.165918991276871 0.438407435745112 no 1918 0.434110350883885 2729 25238761 SGTC_2146 5545642 200 µM -0.166040084541669 0.438358737956877 no 1919 0.434062702538991 2707 825326 SGTC_121 0557-0495 61.343 µM -0.167432419036602 0.437798876366423 no 1920 0.433514909248011 2693 3104427 SGTC_3257 9139206 32.98 µM -0.167556239659497 0.437749093759565 no 1921 0.433466200033604 2811 4910041 SGTC_1843 st055809 45.5 µM -0.169389610058415 0.437012095132133 no 1922 0.432745097694691 2838 16413835 SGTC_2814 7977482 42.97 µM -0.169934065829403 0.43679327071652 no 1923 0.432530995039839 2853 6456762 SGTC_2384 9036245 200 µM -0.170887420836019 0.436410150576809 no 1924 0.432156143944355 2773 6462766 SGTC_438 sphingosine 6.67 µM -0.172378948358003 0.435810877455523 no 1925 0.431569810609806 2713 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2914 7968218 45.32 µM -0.172424483349562 0.435792584497987 no 1926 0.431551912745978 2812 2977111 SGTC_863 0466-0191 129 µM -0.174941445530189 0.434781649769993 no 1927 0.430562821790832 2785 765160 YPR165W RHO1 SGTC_590 k048-0076 22.4 µM -0.176203720268638 0.434274818755452 no 1928 0.430066949082799 2822 6832814 SGTC_2120 5538279 151.968 µM -0.177629748275363 0.433702367191183 no 1929 0.429506880155776 2747 2058197 SGTC_2967 9089538 49.85 µM -0.178560918556649 0.43332864171985 no 1930 0.429141241846061 2956 728216 SGTC_554 4483-2211 187 µM -0.178649981958465 0.433292899215054 no 1931 0.429106272914097 2824 747107 SGTC_1285 0929-0069 65.5 µM -0.179717999719443 0.432864329941749 no 1932 0.428686980895463 2759 1206237 SGTC_2453 5731132 22.18 µM -0.180091758590303 0.432714368319064 no 1933 0.428540266261055 2845 1362040 SGTC_328 k915-0120 63.5 µM -0.180424477950669 0.4325808809503 no 1934 0.428409669509836 2863 6624543 SGTC_1150 3909-7983 10.9 µM -0.180556698671066 0.432527835989184 no 1935 0.428357773303584 2747 23965914 SGTC_198 3454-2873 16.191 µM -0.181797009145168 0.432030301445529 no 1936 0.427871015883535 2730 710957 SGTC_219 mitoxanthrone 164.414 µM -0.181898684062292 0.43198952063359 no 1937 0.427831118618207 2799 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2238 6671620 73.2395 µM -0.182382426993332 0.431795506022272 no 1938 0.427641307873019 2676 729941 SGTC_2188 6126565 140.678 µM -0.1831981455041 0.431468383360177 no 1939 0.427321274708745 2830 874518 SGTC_98 0074-0023 107.663 µM -0.18477371026422 0.43083667739317 no 1940 0.426703264472469 2801 3563821 SGTC_12 0849-0099 9.267 µM -0.184777632449232 0.430835105054809 no 1941 0.426701726231798 2716 6071388 SGTC_910 3454-3003 490 µM -0.185841459338545 0.430408675207952 no 1942 0.426284545488103 2777 820824 SGTC_1866 st057638 64 µM -0.187959832907743 0.429559777578497 no 1943 0.42545406930615 2757 688802 SGTC_1245 0418-0076 17.2 µM -0.189553045278289 0.428921542546655 no 1944 0.424829692224096 2923 6790114 SGTC_1902 st060212 70.5 µM -0.189687671401956 0.428867620305684 no 1945 0.424776941103904 2739 688944 SGTC_976 1348-1067 47.6 µM -0.190170797455625 0.428674123187552 no 1946 0.424587646888361 2753 5310671 YGL099W LSG1 SGTC_1885 st057546 99.9 µM -0.190331201025656 0.428609883641782 no 1947 0.424524802810965 2896 702008 SGTC_2368 9071271 200 µM -0.190361694708584 0.428597671531862 no 1948 0.424512855991054 2763 27209959 SGTC_1572 epiandrosterone 68.9 µM -0.192360590386466 0.427797303465631 no 1949 0.423729880096931 2737 441302 A steroid. SGTC_747 3448-8087 38.7 µM -0.192456954732262 0.427758726166042 no 1950 0.423692141356108 2811 5168703 SGTC_3113 9123498 49.47 µM -0.19532725064939 0.426609985930767 no 1951 0.422568382492665 2724 8897275 SGTC_252 miconazole 1.30953 nM -0.196312832719238 0.426215682593613 no 1952 0.422182658879854 2832 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_834 0312-0008 75.7 µM -0.196423224280606 0.426171522657063 no 1953 0.422139459983004 2736 6385573 YIL048W NEO1 SGTC_2588 indole-3-carbinol 100 µM -0.197160968646624 0.425876426568356 no 1954 0.421850786781552 2893 3712 Induces cell cycle arrest. SGTC_2057 5236571 38.335 µM -0.199208560096003 0.425057612553456 no 1955 0.421049801816075 2892 54684039 YBR257W POP4 SGTC_3320 9137005 35.139 µM -0.199948517948222 0.424761789159933 no 1956 0.420760422344749 2808 4908713 SGTC_1189 1431-2119 7.28 µM -0.200136480887875 0.424686651304427 no 1957 0.420686921435382 2766 3107275 SGTC_2739 tacrine 100.86 µM -0.202371417093557 0.423793449924849 no 1958 0.419813185973689 2854 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1612 st002233 45.4 µM -0.202512498343008 0.423737079312552 no 1959 0.41975804428368 2748 1035021 SGTC_1403 3909-7815 62.9 µM -0.203939033777905 0.423167178771236 no 1960 0.419200570743693 2739 6615483 SGTC_1276 0871-0068 94.2 µM -0.204872467185414 0.422794359280232 no 1961 0.418835883470459 2858 3414906 SGTC_859 0439-0102 54.6 µM -0.204980077279132 0.422751383533977 no 1962 0.418793845278858 2778 610143 SGTC_2667 digitoxin 100 µM -0.206585026772881 0.422110531649814 no 1963 0.418166977460964 2853 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3157 9099274 49.47 µM -0.20684527255165 0.422006635613274 no 1964 0.418065349126884 2831 17217662 SGTC_2521 angolensin 13.4 µM -0.206927350469489 0.421973869366382 no 1965 0.418033298090888 2915 821428 A flavenoid. SGTC_74 000s-0487 160.283 µM -0.20700172060948 0.421944180600495 no 1966 0.418004257375502 2743 677548 SGTC_2025 5147754 141 µM -0.207048801557251 0.42192538598502 no 1967 0.417985873018306 2864 315777 YLR208W SEC13 SGTC_3271 9137798 49.47 µM -0.207495425962281 0.421747103310762 no 1968 0.417811482249579 2913 6498326 SGTC_1164 k060-0068 93.7 µM -0.207851216064002 0.421605091174577 no 1969 0.417672570572749 2772 5963676 SGTC_2768 sulfasalazine 50.2 µM -0.207889248510226 0.421589911285043 no 1970 0.417657722113681 2838 5384001 An antioxidant and salicylic acid derivative. SGTC_1445 4239-0156 97.7 µM -0.208120646561744 0.421497555897145 no 1971 0.417567383242955 2958 4008346 SGTC_178 4092-0806 87.505 µM -0.208140245814684 0.421489733658758 no 1972 0.417559731803642 2799 2169044 SGTC_2743 auranofin 4.32 µM -0.209097513708494 0.421107717190144 no 1973 0.417186057790433 2805 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1348 1493-0373 93.8 µM -0.209901670960194 0.420786859896444 no 1974 0.416872209022787 2854 3010129 SGTC_2012 4023501 200 µM -0.2101379835463 0.420692581593494 no 1975 0.416779990339688 2858 3477460 SGTC_3275 9138069 49.47 µM -0.21135211929959 0.420208266794512 no 1976 0.416306258009352 2852 17617007 SGTC_2235 salicylic acid 500 µM -0.211496316853267 0.420150754870384 no 1977 0.416250002969981 2780 338 A COX inhibitor and kinase inhibitor. SGTC_2115 tiliquinol 12.7705 µM -0.21298505142279 0.419557086082479 no 1978 0.415669311211145 2892 71208 A bioactive hydroxyquinoline. SGTC_35 0133-0054 64.071 µM -0.213581937614786 0.419319114660558 no 1979 0.415436543038712 2820 99677 SGTC_841 0251-0215 91.2 µM -0.215293570631285 0.418636870871505 no 1980 0.414769220997807 2842 3888614 SGTC_480 am 92016 50 µM -0.216182955084934 0.41828246551212 no 1981 0.414422569642652 2842 2129 K+ channel blocker. SGTC_360 0957-0399 1.01 µM -0.218503976815832 0.417357888928144 no 1982 0.41351823006324 2954 6752301 YPR165W RHO1 SGTC_175 3793-3120 23.7 µM -0.219647835865082 0.41690240156622 no 1983 0.413072716699257 2808 5322297 SGTC_1769 st044406 64.4 µM -0.219682322031022 0.416888670822698 no 1984 0.413059286667843 2792 670903 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.220286898637636 0.416647973787306 no 1985 0.41282386147108 2892 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_561 1550-0330 72.9 µM -0.220481056050968 0.416570681499904 no 1986 0.412748262236726 2794 6812934 SGTC_2761 levamisole 97.89 µM -0.221846061763041 0.41602737644672 no 1987 0.412216860327925 2931 26879 An alkaline phosphatase inhibitor. SGTC_789 1309-1135 70.6 µM -0.222724635387087 0.415677767843829 no 1988 0.411874913326389 2782 3092424 SGTC_551 k048-0028 34.9 µM -0.224724888953816 0.414882061282734 no 1989 0.411096650602384 2965 6836383 SGTC_2765 myclobutanil 7.74 µM -0.224935917954498 0.414798133646032 no 1990 0.41101456335469 2903 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2375 9072683 200 µM -0.225039447043675 0.414756960860569 no 1991 0.410974293451703 2947 16798029 SGTC_387 norethindrone acetate 66.7 µM -0.226374323936674 0.414226173805456 no 1992 0.410455148077254 2854 541197 SGTC_1256 0570-0116 285 µM -0.226379796272077 0.414223998162605 no 1993 0.410453020160071 2827 410638 SGTC_1515 3460-0031 42.1 µM -0.227191348922989 0.41390137739099 no 1994 0.410137477193416 2824 2876596 SGTC_2911 7942208 15.64 µM -0.22850180708463 0.413380546845408 no 1995 0.40962807571533 2913 1243384 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.228942558019786 0.413205408302018 no 1996 0.409456781183411 2844 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.229441936105535 0.413006994312143 no 1997 0.409262722537941 2965 5393153 SGTC_2897 9048598 12.99 µM -0.230990565072905 0.412391831188023 no 1998 0.408661065912799 2828 6467404 SGTC_2445 5742597 35.57 µM -0.231315434464161 0.41226281031144 no 1999 0.408534878420319 2812 1774255 SGTC_1264 0783-0040 158 µM -0.232657091848844 0.411730075802698 no 2000 0.408013845323346 2771 2855798 SGTC_3248 9135562 49.47 µM -0.232796468903068 0.411674742394896 no 2001 0.407959727506151 2866 17650701 SGTC_2918 7977171 22.06 µM -0.23388536638286 0.411242505040922 no 2002 0.407536987052889 2771 2236483 SGTC_1801 st050089 28.441 µM -0.233939231715694 0.411221126013693 no 2003 0.407516077814694 2813 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2455 5377712 9.75 µM -0.235805435186569 0.41048059735511 no 2004 0.406791825205081 2905 2243908 SGTC_670 4204-0025 119 µM -0.236291800859729 0.410287654773857 no 2005 0.406603124396505 2931 719039 SGTC_2978 9011784 42.97 µM -0.237202307336737 0.409926512792858 no 2006 0.406249923197576 2955 2994934 SGTC_2983 9022671 12.99 µM -0.237803174063649 0.409688227699737 no 2007 0.40601687836853 3029 6405161 SGTC_25 0118-0223 35.662 µM -0.237930036563007 0.40963792223182 no 2008 0.40596767928367 2971 5333628 SGTC_1839 st053978 48 µM -0.23842105855629 0.409443228673582 no 2009 0.405777267962366 2893 3788398 SGTC_464 bw-b 70c 158 µM -0.239004266933157 0.409212011605536 no 2010 0.405551137040921 2955 5353454 SGTC_273 hydroxyurea 18.1 mM -0.239178076354504 0.40914310974147 no 2011 0.405483750952675 2825 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1274 0865-0114 173 µM -0.239248093375377 0.409115354252849 no 2012 0.405456606074364 2870 870624 SGTC_938 3126-1755 342 µM -0.239462362275513 0.409030418622947 no 2013 0.405373539052742 2993 1777771 SGTC_2212 7123476 200 µM -0.239521571609395 0.409006948951356 no 2014 0.405350585735644 2854 1085715 SGTC_1934 st074720 32.6 µM -0.241695898572863 0.408145305722901 no 2015 0.404507903912247 2821 17250992 SGTC_3287 9117173 37.0625 µM -0.242771377450019 0.407719278337648 no 2016 0.404091254903289 2895 2789709 SGTC_3087 9117406 49.47 µM -0.24321208289294 0.407544734020493 no 2017 0.403920553527217 2965 42546093 SGTC_596 1155-0152 116 µM -0.243462740642287 0.407445467539882 no 2018 0.403823472750989 2856 280313 SGTC_26 0302-0163 425.158 µM -0.243787261994696 0.407316958129863 no 2019 0.403697793098743 2841 3100915 SGTC_3266 9136860 49.47 µM -0.244276997633405 0.4071230432843 no 2020 0.40350814858301 2861 4871271 YPR165W RHO1 SGTC_2394 5221648 200 µM -0.244827062827342 0.406905267600196 no 2021 0.403295169190376 2963 788586 SGTC_2005 4024620 188 µM -0.246418387676337 0.406275410294362 no 2022 0.402679186851361 2835 236743 SGTC_1841 st054148 70 µM -0.24659162538447 0.406206856224963 no 2023 0.402612143208499 2930 675442 SGTC_683 panaxydol 45 µM -0.24785001741208 0.40570896853868 no 2024 0.402125226852875 2879 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1219 1469-0211 33.1 µM -0.248206502640691 0.405567951460052 no 2025 0.40198731768599 2951 6822282 SGTC_2387 9077560 195.08 µM -0.248433329457115 0.405478230544444 no 2026 0.401899574265664 2846 5303272 SGTC_698 k064-0052 127 µM -0.249779514515226 0.404945851957595 no 2027 0.401378931373287 2821 5088751 SGTC_914 3820-6779 408 µM -0.250927805122632 0.40449187405027 no 2028 0.400934963312362 2810 2893481 SGTC_1715 st032160 10.2275 µM -0.25320954101191 0.403590169426949 no 2029 0.400053147025397 2967 5289825 SGTC_2281 7943571 200 µM -0.253472767181771 0.403486179622561 no 2030 0.399951451407053 3046 1244024 SGTC_216 k038-0035 28.382 µM -0.253644432196153 0.403418365530228 no 2031 0.39988513346559 2929 4444231 YPR107C YTH1 SGTC_2940 9060638 45.86 µM -0.253674067807547 0.403406658650725 no 2032 0.399873684874368 2961 4027022 SGTC_1950 st077106 7.18 µM -0.253901727742054 0.40331672961833 no 2033 0.399785739988926 2940 13831864 SGTC_2328 6201408 200 µM -0.254236852782333 0.403184359587336 no 2034 0.399656290652895 2980 2890418 SGTC_2222 6885208 172.143 µM -0.256631753731866 0.402238728627926 no 2035 0.398731529904597 2896 609514 SGTC_1722 st034304 3.6505 µM -0.257056803255728 0.402070956653819 no 2036 0.398567461628814 2866 4036148 YLR033W RSC58 SGTC_2448 5185112 27.17 µM -0.259265092472523 0.401199610320192 no 2037 0.397715355465127 2999 5718189 SGTC_787 4152-0075 138 µM -0.261495377119201 0.400320083529803 no 2038 0.396855257031149 2882 9566539 SGTC_960 1222-0186 7.7 µM -0.262605290062722 0.399882570381099 no 2039 0.396427411127609 2981 3126296 SGTC_1730 st033808 45.1 µM -0.262890908695676 0.399770003561983 no 2040 0.396317331867635 2856 1045166 SGTC_1623 st003709 20.3 µM -0.263440130451367 0.399553570000188 no 2041 0.396105681501626 2861 16192618 SGTC_147 4466-0538 29.23 µM -0.263613902986109 0.399485097329693 no 2042 0.396038722173394 3090 6742687 YHR072W ERG7 SGTC_730 1436-0052 41.2 µM -0.264393303525098 0.399178023356075 no 2043 0.395738435505985 2870 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1198 1612-1005 86.7 µM -0.266144379390879 0.398488349336052 no 2044 0.395064008650386 3074 6998509 SGTC_1484 3473-2379 286 µM -0.266340855540471 0.398410985505002 no 2045 0.394988355434648 2876 671917 SGTC_717 1532-0246 73.2 µM -0.266388782309833 0.398392114616582 no 2046 0.394969901814486 2952 9561992 SGTC_2156 5649887 115 µM -0.266680260876679 0.398277351734027 no 2047 0.394857676609203 2982 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_633 0437-0093 97.7 µM -0.266828628285091 0.398218938908259 no 2048 0.394800555474342 2880 2831118 SGTC_2869 9037858 32.47 µM -0.267216964537605 0.398066060215982 no 2049 0.394651057556005 2840 27187042 SGTC_953 1188-0045 9.7 µM -0.267394903633713 0.397996015077044 no 2050 0.394582561472439 2997 6144426 SGTC_1848 st056003 16.4 µM -0.268707171759173 0.397479546716243 no 2051 0.394077516220361 2899 146492 SGTC_2558 carylophyllene oxide 100 µM -0.26892362847983 0.397394373249146 no 2052 0.393994226825524 2847 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1826 st055655 41.6 µM -0.269079770575688 0.39733293599635 no 2053 0.393934148630014 2940 676168 SGTC_1012 4112-3522 18 µM -0.269224713061484 0.397275907735301 no 2054 0.39387838192453 3041 3112398 SGTC_3212 9128307 49.47 µM -0.270057685924087 0.396948213493374 no 2055 0.393557937353697 2838 27243542 SGTC_1912 st060209 90.8 µM -0.271397762220694 0.396421175859053 no 2056 0.393042561485172 2953 688787 SGTC_1086 cerivastatin 2.18 µM -0.271505319114367 0.396378883076426 no 2057 0.393001204619409 2879 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_865 0488-0499 301 µM -0.272588957162185 0.395952850475181 no 2058 0.392584600748347 3008 9634651 SGTC_1570 verbenone 133 µM -0.273090115034202 0.395755862107782 no 2059 0.392391972546413 3078 29025 A natural terpanoid with antifungal properties. SGTC_2254 7938975 95.19 µM -0.273291341531895 0.395676774202331 no 2060 0.392314635274929 3082 2969277 SGTC_867 0518-0118 155 µM -0.274826838276709 0.395073420689706 no 2061 0.391724638893635 2965 6848158 SGTC_2217 6934799 96.0675 µM -0.275541989541007 0.394792497039912 no 2062 0.391449935404388 2970 675606 SGTC_1708 st033234 31.827 µM -0.275576089303162 0.394779103434978 no 2063 0.391436838374427 3020 674664 SGTC_367 0335-0881 7.1 µM -0.276038999760126 0.39459729512733 no 2064 0.391259055998414 3058 23828853 SGTC_2704 st078022 71.1 µM -0.277832137182915 0.393893256547737 no 2065 0.390570610053794 3055 54697681 SGTC_721 1187-1332 279 µM -0.278036683348436 0.393812967681114 no 2066 0.390492099630621 2834 25730 SGTC_2567 aureobasidin a 60 nM -0.281382359824284 0.39250035916379 no 2067 0.389208573298846 3148 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1090 efavirenz 20.7 µM -0.281528218505996 0.392443162148973 no 2068 0.389152643844904 2944 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2261 9010538 184.68 µM -0.281753470160249 0.392354836543257 no 2069 0.389066275699291 3019 6457250 SGTC_892 0929-0076 29 µM -0.281860333411975 0.392312935298666 no 2070 0.389025303085089 2926 5751038 SGTC_2936 9038235 15.59 µM -0.28201358556445 0.392252847074252 no 2071 0.388966546580602 2870 4749415 SGTC_2714 st079313 56.9 µM -0.283666489855869 0.39160492783484 no 2072 0.388332988729874 2902 2939799 SGTC_518 1021-0119 62.6 µM -0.283739002810076 0.391576510470383 no 2073 0.388305201319133 2952 1097762 SGTC_1664 st014217 9.02 µM -0.28454113173983 0.391262199887942 no 2074 0.387997858743046 2940 3982782 SGTC_2902 5787006 60.46 µM -0.284717018421969 0.3911932889728 no 2075 0.387930475622698 2911 591003 SGTC_2196 6573537 42.6665 µM -0.285794574637271 0.390771186192478 no 2076 0.387517731856242 3020 2903087 SGTC_520 3584-0023 682 µM -0.285976021810065 0.390700121935765 no 2077 0.387448243387876 2960 1340790 SGTC_1743 st037606 46.3785 µM -0.287531224712308 0.390091172642595 no 2078 0.386852798489835 2932 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2154 5570129 200 µM -0.288357477062868 0.389767758007955 no 2079 0.386536557135334 2920 673366 SGTC_1925 st057770 10.1 µM -0.288559774999425 0.389688585450298 no 2080 0.386459140721747 2925 5989122 SGTC_2793 7325131 81.82 µM -0.288615816149649 0.389666653652534 no 2081 0.386437695405706 2980 4176441 SGTC_2247 cerulenin 830 nM -0.289820243574882 0.389195383993954 no 2082 0.385976880044755 3139 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_866 0495-0101 262 µM -0.291022521111301 0.388725118049061 no 2083 0.385517047630644 2899 635694 SGTC_133 0724-0033 378.92 µM -0.291132922351807 0.388681943216719 no 2084 0.385474830768567 2842 280309 SGTC_1427 4048-4900 550 nM -0.291299045750637 0.388616979600613 no 2085 0.385411308599146 3035 24132586 SGTC_1359 1582-0056 520 nM -0.292018760960253 0.388335566375412 no 2086 0.385136139839563 3028 3661189 SGTC_600 1495-0418 41.6 µM -0.295133160480188 0.387118493667002 no 2087 0.383946079467936 2924 5377768 SGTC_2232 chlorophetanol 41.5365 µM -0.297620082820269 0.386147427686179 no 2088 0.38299657247245 2995 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3202 9113761 49.47 µM -0.297714040597882 0.386110754026424 no 2089 0.382960713129918 3082 4798415 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.298264394555577 0.385895959965795 no 2090 0.382750688607132 3001 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_750 4073-0104 132 µM -0.299054920522293 0.385587491954489 no 2091 0.38244907065657 3000 22330957 SGTC_1759 st043059 70 µM -0.299775051302914 0.385306555536926 no 2092 0.382174373397404 2922 669426 SGTC_1078 idebenone 36.1 µM -0.301019734605173 0.384821123388288 no 2093 0.381699723007366 3003 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3055 9094636 49.47 µM -0.301220720999045 0.384742754686906 no 2094 0.381623095050442 3108 25236176 SGTC_126 0417-1624 672.48 µM -0.302152966206548 0.384379314858675 no 2095 0.381267728484682 3037 41912 YDL195W SEC31 SGTC_2738 aclarubicin 5.55 µM -0.302242764658801 0.384344311904038 no 2096 0.381233503106149 3000 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_385 1494-0393 12.4 µM -0.303085383894197 0.384015909429401 no 2097 0.38091239628405 2980 3090647 SGTC_2889 9059656 51.95 µM -0.305507549189125 0.383072359001404 no 2098 0.379989810609011 3035 3949838 SGTC_471 1-acyl-paf 4 µM -0.306990166128537 0.382495149759592 no 2099 0.379425428675142 2932 16759367 SGTC_571 k831-0106 44.2 µM -0.307509564956737 0.382293000181303 no 2100 0.37922777186201 3055 4783639 SGTC_660 4031-1742 102 µM -0.307975510950785 0.382111681693297 no 2101 0.37905048334261 2948 6738706 SGTC_169 k015-0017 16.025 µM -0.30805610361715 0.382080322438807 no 2102 0.379019821092645 3179 1840002 SGTC_932 2857-0803 154 µM -0.308412525710245 0.381941645014951 no 2103 0.378884226032001 3171 674898 SGTC_1011 4112-3381 17.4 µM -0.308465054673567 0.381921208220666 no 2104 0.37886424349139 3114 2877139 SGTC_864 0469-0573 172 µM -0.31062684994932 0.381080431306851 no 2105 0.378042156478885 2940 689425 SGTC_630 4356-0227 183 µM -0.311067584298177 0.380909087288316 no 2106 0.377874621732026 2969 779312 SGTC_3327 9140648 26.9345 µM -0.311435477054276 0.380766079729666 no 2107 0.377734793580982 3084 8029710 SGTC_1800 st050079 29.0735 µM -0.311528078831515 0.380730086059901 no 2108 0.3776996001533 3052 3645560 SGTC_1254 0550-0035 264 µM -0.31342317640996 0.379993701892975 no 2109 0.376979589195104 3098 15121435 SGTC_2537 larixol 68.93 µM -0.313433594653498 0.379989654842051 no 2110 0.376975632135418 2973 6708759 SGTC_3068 9116768 49.47 µM -0.313964694727432 0.379783362145165 no 2111 0.376773926709375 3064 41904888 SGTC_3037 9091026 49.47 µM -0.316806932951105 0.378679947681971 no 2112 0.375695051628413 3060 25236398 YIL048W NEO1 SGTC_483 fpl-64176 144 µM -0.317754626788134 0.378312252974667 no 2113 0.37533553537767 2972 3423 SGTC_537 1334-0398 209 µM -0.318389557091758 0.378065968660807 no 2114 0.375094729346704 3128 5846986 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.319983184955649 0.377448031770547 no 2115 0.374490538708934 2950 6708514 SGTC_733 4069-0007 56.1 µM -0.320536349784433 0.377233612678391 no 2116 0.374280889790212 2996 5717425 YNL287W SEC21 SGTC_2960 9079389 5.97 µM -0.320580180332676 0.377216624592252 no 2117 0.374264279644621 3133 16457355 SGTC_2939 9044578 71.43 µM -0.322270797223969 0.376561547592031 no 2118 0.373623777190222 2935 2653634 SGTC_1417 3966-0327 90.4 µM -0.322542728996861 0.376456213111963 no 2119 0.373520786396441 3020 651118 SGTC_512 prima-1 270 µM -0.325843458973905 0.375178390287443 no 2120 0.372271398025104 3135 322968 A re-activator of the apoptotic function of mutant p53. SGTC_304 1310-0298 97 µM -0.327792976446549 0.374424308903589 no 2121 0.371534099088546 3033 1550234 SGTC_1037 k284-1091 78.7 µM -0.328575639180753 0.374121706628786 no 2122 0.371238231848043 2952 3334711 SGTC_116 0155-0182 31.788 µM -0.328919035402234 0.373988963205744 no 2123 0.371108442984743 3001 771486 SGTC_2094 5332512 191.667 µM -0.330687156890317 0.373305714090321 no 2124 0.370440402174128 3138 755774 SGTC_112 phenothiazine 287.218 µM -0.334895089377379 0.371681262067106 no 2125 0.368852113269308 3151 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1042 0350-0096 82 µM -0.33590954063829 0.371289978384059 no 2126 0.368469541148004 2991 3122515 SGTC_2216 7189485 200 µM -0.336509142375443 0.371058768689548 no 2127 0.368243479270455 3106 731273 SGTC_1978 st071761 42 µM -0.336587803882808 0.371028439835334 no 2128 0.368213825687523 3009 5147680 SGTC_3240 9133527 49.47 µM -0.33726743452565 0.370766433757516 no 2129 0.367957653245913 3010 17617455 SGTC_765 1319-0117 244 µM -0.337598337947993 0.37063888804649 no 2130 0.367832947423395 3007 3487746 YGL099W LSG1 SGTC_2576 guaiol 23.12 µM -0.337753216602545 0.370579195426438 no 2131 0.367774583909234 3092 227829 SGTC_1336 1486-0901 104 µM -0.338410457997891 0.370325919144113 no 2132 0.367526947108854 3060 5006114 SGTC_3115 9123671 49.47 µM -0.338457542561131 0.370307776668637 no 2133 0.36750920860061 3089 3286988 SGTC_1674 st016616 23.6 µM -0.34047192593959 0.369531871499628 no 2134 0.366750580572138 2953 625830 SGTC_2543 pimpinellin 60.67 µM -0.341845243949757 0.369003197687126 no 2135 0.366233679346524 3006 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2404 5161160 200 µM -0.342243998786009 0.368849739008517 no 2136 0.366083637987638 2939 2831543 SGTC_3252 9135871 49.47 µM -0.342514542688666 0.368745633528882 no 2137 0.365981850817247 3155 17682838 SGTC_957 1187-1561 14.1 µM -0.342828171402938 0.368624961038244 no 2138 0.36586386558321 3063 1538454 SGTC_522 1273-0010 11.6 µM -0.342997739545002 0.368559723012281 no 2139 0.365800080351712 3235 5705015 SGTC_342 k048-0088 23.3 µM -0.343659144247067 0.368305296712137 no 2140 0.365551319959975 2982 6820570 SGTC_1376 2910-0861 41.3 µM -0.343912600427506 0.368207813581668 no 2141 0.36545600773786 2995 1112859 SGTC_3136 9095672 49.47 µM -0.344273437024232 0.368069044937273 no 2142 0.365320329433521 2967 17217380 SGTC_1897 st060201 15 µM -0.344566277871511 0.367956438394114 no 2143 0.365210230624917 3028 611878 SGTC_592 k241-0073 46.5 µM -0.345038136356891 0.367775017796512 no 2144 0.36503285027456 3148 4230158 SGTC_2054 5233173 129 µM -0.345076503298185 0.367760267734729 no 2145 0.365018428699191 3156 6889 SGTC_2067 5224629 34.075 µM -0.345192964913814 0.367715495591438 no 2146 0.364974653640755 3148 2835000 SGTC_496 calpeptin 138 µM -0.346193436464433 0.367330951510536 no 2147 0.364598673526629 3065 73364 A calpain inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.347660036450906 0.366767485486211 no 2148 0.364047756410075 3126 1377 SGTC_2031 5180455 200 µM -0.347684287376325 0.366758170717132 no 2149 0.364038649091958 3013 29949 SGTC_2979 9012552 45.46 µM -0.348199141846524 0.366560433879754 no 2150 0.363845316106156 3128 17100905 SGTC_262 fenpropimorph 62.5 µM -0.348797973467831 0.36633048903055 no 2151 0.363620492462191 3040 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2779 methotrexate 400 µM -0.349261201483659 0.366152647406288 no 2152 0.363446611656428 3104 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1702 st027038 51 µM -0.349618866551802 0.366015352974656 no 2153 0.36331237500764 3066 5521182 SGTC_2819 7996655 46.38 µM -0.349644970469628 0.366005333314605 no 2154 0.363302578503135 3064 6456960 SGTC_2296 7971656 126.45 µM -0.350911216037523 0.365519410749419 no 2155 0.362827478368178 3088 666570 SGTC_880 0833-0487 87.2 µM -0.351246787516415 0.365390671107814 no 2156 0.362701606028587 3013 76075 SGTC_57 miconazole 162.5 nM -0.351754041012716 0.36519609565743 no 2157 0.362511364197483 3063 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3148 9097893 49.47 µM -0.351958871559453 0.365117535314271 no 2158 0.3624345535693 3015 17174100 SGTC_1770 st043884 66.3 µM -0.352396725543845 0.364949620564036 no 2159 0.362270378665728 3002 670149 SGTC_3160 9100216 49.47 µM -0.352696184092619 0.36483479466135 no 2160 0.36215811020559 3033 17191039 SGTC_3290 9121031 71.43 µM -0.353919155175225 0.364365978380355 no 2161 0.361699735608079 3062 17014854 SGTC_2452 5863136 48.41 µM -0.356123356444471 0.363521527917176 no 2162 0.360874093224654 2992 2184096 SGTC_149 3970-0822 46.1 µM -0.356141489002147 0.363514583904645 no 2163 0.360867303873319 3141 3114250 YBL034C STU1 SGTC_3269 9137823 49.47 µM -0.358244241351007 0.36270962221426 no 2164 0.360080270744589 3000 17682936 SGTC_329 k048-0121 21.3 µM -0.362378443589768 0.361128765257874 no 2165 0.358534622966617 3112 6832902 SGTC_1284 0929-0043 16 µM -0.362878992627652 0.360937523048912 no 2166 0.358347640054079 3092 1239883 SGTC_2415 st077333 57.7 µM -0.364068422535565 0.360483223170354 no 2167 0.357903458115569 3276 2766255 SGTC_226 1,3-diallylurea 8.28947 mM -0.36532349300152 0.360004065508014 no 2168 0.357434971825755 3130 74537 YKL182W FAS1 SGTC_3247 9135149 49.47 µM -0.36571256886663 0.359855569711697 no 2169 0.357289783151775 3061 8934436 YOR116C RPO31 SGTC_2553 4-methylesculetin 85.09 µM -0.368906360206883 0.358637419514588 no 2170 0.356098761229577 3112 5319502 SGTC_2185 6113692 200 µM -0.370287900533966 0.358110927929275 no 2171 0.355583994053335 3181 874150 SGTC_1878 temozolomide 1 mM -0.371941522364792 0.3574811033957 no 2172 0.354968194497442 3183 5394 DNA alkylating agent. SGTC_1058 3448-5425 97.3 µM -0.37236662091531 0.35731925626523 no 2173 0.354809951286478 3084 7279705 SGTC_1263 0774-1208 64.8 µM -0.37242094422405 0.357298575682488 no 2174 0.354789731203942 3236 906585 SGTC_1252 0493-0875 34.8 µM -0.373378213693608 0.356934217317077 no 2175 0.354433485983521 3039 3960963 SGTC_2210 7115885 190.385 µM -0.37369225004243 0.356814716397957 no 2176 0.354316645932017 3081 2927039 SGTC_1269 0831-0796 3.05 µM -0.373791061345495 0.356777118428247 no 2177 0.354279885132182 3187 927758 SGTC_881 0833-0569 170 µM -0.375022735534718 0.356308579913853 no 2178 0.35382177903892 3085 5418700 SGTC_209 4077-0173 175.592 µM -0.37568793015057 0.356055624797307 no 2179 0.353574456010078 3137 15993494 SGTC_2292 7671323 168.05 µM -0.376217247842695 0.355854385167724 no 2180 0.353377696920273 3221 937504 SGTC_3015 9080845 49.47 µM -0.376504783106188 0.355745084868904 no 2181 0.353270830123903 3199 5296973 SGTC_3353 9151644 39.2805 µM -0.37792994343252 0.355203516262092 no 2182 0.352741318815954 3186 4909158 SGTC_1534 6-azauridine 81.6 µM -0.37836011612846 0.355040105704225 no 2183 0.352581546244611 3059 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.380550107803044 0.354208603108746 no 2184 0.351768554279913 3074 641818 YHR062C RPP1 SGTC_963 1269-2853 151 µM -0.380921770865434 0.354067557800236 no 2185 0.351630648702173 3065 3668223 SGTC_3256 9138902 49.47 µM -0.381568877277326 0.353822030135394 no 2186 0.35139058646675 3084 17228773 SGTC_826 1683-5028 118 µM -0.385190233097808 0.352449125503348 no 2187 0.350048239498495 3154 722377 SGTC_1864 st057645 30.4 µM -0.385885800391711 0.352185645872793 no 2188 0.349790623671822 3173 688666 SGTC_3313 9133968 57.047 µM -0.388830283236951 0.351071068174284 no 2189 0.348700848695899 3144 1494643 SGTC_47 0149-0135 24.25 µM -0.390245696712289 0.350535745373063 no 2190 0.348177436940628 3075 5239155 SGTC_2239 6685329 187.64 µM -0.390269009623874 0.350526930689574 no 2191 0.348168818377173 3212 805680 SGTC_1932 st074806 40.9 µM -0.390419847398277 0.350469900408922 no 2192 0.348113056970291 3327 17251235 SGTC_1579 chlormadinone acetate 49.4 µM -0.392565513227716 0.349659010770515 no 2193 0.347320207612855 3213 45114258 A steroidal progestin. SGTC_2077 5212015 200 µM -0.393622487497336 0.349259810994236 no 2194 0.346929888117106 3067 780900 SGTC_1097 itavastatin 7.23 µM -0.396231660646493 0.348275088679478 no 2195 0.345967068404934 3129 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2654 protoveratrine a 100 µM -0.396715753641029 0.348092500396704 no 2196 0.345788540881173 3110 5702278 A heart drug and vasodilator. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.396742517040352 0.348082406910244 no 2197 0.345778671869435 3250 16725076 SGTC_1901 st060216 58.6 µM -0.396961895342553 0.347999675142496 no 2198 0.345697780003429 3077 688792 SGTC_3053 9095903 49.47 µM -0.397102815878212 0.347946535120221 no 2199 0.345645821765716 3184 17174018 SGTC_266 formosanin C 406 nM -0.397414722431424 0.34782892824027 no 2200 0.345530830309416 3184 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3028 9087778 49.47 µM -0.398519890848003 0.347412333480582 no 2201 0.345123499583067 3105 17217395 SGTC_2362 9071156 126 µM -0.398956835821936 0.347247677265342 no 2202 0.344962504699031 3249 653133 SGTC_651 3253-0966 34.4 µM -0.399047176493742 0.347213637321985 no 2203 0.344929221659872 3116 781462 SGTC_2460 5552655 174.22 µM -0.399288418065627 0.347122744664753 no 2204 0.344840350044536 3227 5401989 SGTC_2421 5690543 90.72 µM -0.399566101931269 0.347018132520616 no 2205 0.344738063954775 3198 3397993 SGTC_1821 st053465 65.6 µM -0.401286761012424 0.346370166962665 no 2206 0.344104504793837 3168 675086 SGTC_1420 4'-methoxyflavone 42 µM -0.402077544866585 0.346072524285124 no 2207 0.343813479017147 3192 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2433 5607874 27.82 µM -0.402700020942653 0.345838297734839 no 2208 0.343584459258406 3094 2252428 SGTC_1983 st071813 46.9 µM -0.403967009183183 0.345361735145589 no 2209 0.343118489680966 3175 11838595 SGTC_22 0964-0034 14.468 µM -0.404543784795408 0.345144868968333 no 2210 0.342906443614415 3177 138402 SGTC_1958 st076513 41.9 µM -0.405046812221231 0.344955773428814 no 2211 0.342721550752185 3089 732122 YGL099W LSG1 SGTC_3314 9135860 59.4275 µM -0.405581601185773 0.344754780710908 no 2212 0.342525024923957 3237 25252478 SGTC_1641 st009299 47.1 µM -0.408069127757739 0.343820456330906 no 2213 0.341611462266296 3210 4046054 SGTC_2497 7-hydroxyflavone 100 µM -0.408637984133446 0.343606925413177 no 2214 0.341402675572026 3258 5281894 SGTC_1526 st051518 75 µM -0.408952773400465 0.343488784792855 no 2215 0.341287159686923 3129 673993 SGTC_2884 9058502 51.95 µM -0.409631804770996 0.343233995940678 no 2216 0.34103803122135 3223 6471554 SGTC_1088 bifonazole 369 nM -0.409867870280771 0.343145435183927 no 2217 0.340951437842972 3200 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1578 josamycin 24.2 µM -0.409978906113018 0.343103782702784 no 2218 0.340910710656713 3123 5282165 A P450 substrate. SGTC_2370 9071495 200 µM -0.410340447289701 0.342968172243991 no 2219 0.340778112666317 3197 21791103 SGTC_2912 7964298 10.93 µM -0.410346361882052 0.342965953907997 no 2220 0.340775943607845 3204 2975850 SGTC_1215 3852-0577 11.2 µM -0.413004046328617 0.341969707454655 no 2221 0.339801824581921 3278 2884876 SGTC_1385 3091-4834 14.1 µM -0.413047079355773 0.341953585332454 no 2222 0.339786060496103 3216 4072814 SGTC_1622 st003707 19.4 µM -0.413904078950176 0.341632574495768 no 2223 0.339472178263715 3242 10140899 SGTC_2023 5144124 124 µM -0.414323990173456 0.341475327926827 no 2224 0.339318423396988 3109 2830192 SGTC_119 0121-0043 24.815 µM -0.414805655408088 0.341294989858981 no 2225 0.339142089594917 3206 1092378 SGTC_1496 4469-0713 57.4 µM -0.4154612320701 0.341049596642739 no 2226 0.338902144815226 3245 746691 SGTC_1306 1185-0270 9.02 µM -0.416432792441951 0.340686049135334 no 2227 0.338546668406727 3239 1548076 SGTC_2616 abietic acid 100 µM -0.417145765757936 0.340419356233993 no 2228 0.338285895799099 3289 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.418583951195497 0.339881635315553 no 2229 0.337760110285453 3240 229346 A bile salt which induces apoptosis. SGTC_312 4092-0653 6.84 µM -0.41910055029066 0.339688564312767 no 2230 0.337571324271702 3216 1148278 SGTC_3296 9122258 64.045 µM -0.422076178607991 0.338577288900337 no 2231 0.336484707388375 3228 4730474 SGTC_902 1120-0002 2.07 µM -0.422468667840983 0.338430814837951 no 2232 0.336341482854358 3148 3280475 SGTC_2796 7949634 45.45 µM -0.424266802040433 0.337760077312792 no 2233 0.335685623683612 3118 2971588 SGTC_2486 5283202 22.39 µM -0.424893517119658 0.337526421824497 no 2234 0.33545715039248 3166 1377751 SGTC_3270 9137563 49.47 µM -0.424915239886798 0.337518324141088 no 2235 0.335449232298729 3208 17015724 SGTC_2201 6605497 169.863 µM -0.426967278425441 0.336753717185152 no 2236 0.334701580520704 3189 670741 SGTC_194 1486-1323 56.904 µM -0.427496421053904 0.336556663379329 no 2237 0.334508895672174 3193 5178754 SGTC_2984 9022109 38.96 µM -0.427859665548486 0.336421416353842 no 2238 0.334376647089419 3277 6459207 SGTC_893 0958-0369 48.9 µM -0.428487927525932 0.336187545183848 no 2239 0.334147960538108 3257 6819948 SGTC_315 k915-0449 187 µM -0.428489756544082 0.336186864422447 no 2240 0.334147294867681 3211 20970215 YNL149C PGA2 SGTC_2284 7945075 39.21 µM -0.428641069458735 0.336130547546457 no 2241 0.33409222639964 3271 1245402 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.429257486636762 0.335901162389378 no 2242 0.333867925896726 3160 5106787 A p450 inhibitor. SGTC_454 lyso-paf C-16 6.67 µM -0.431012441903095 0.335248431966834 no 2243 0.333229661913376 3209 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_983 1491-0821 12.2 µM -0.431204723626598 0.335176945721761 no 2244 0.333159759808115 3261 46495113 SGTC_408 cantharidin 100 µM -0.433574372541886 0.334296451542004 no 2245 0.332298774016528 3188 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_288 1315-0019 35.1 µM -0.434488973074655 0.333956855353632 no 2246 0.33196670026555 3284 6811474 SGTC_640 3381-0960 37.1 µM -0.435598911425927 0.333544911748326 no 2247 0.331563880365989 3246 1745025 SGTC_1861 st057647 17.4 µM -0.436485448684577 0.333216025527724 no 2248 0.331242277257665 3339 688668 SGTC_3036 9090181 49.47 µM -0.436920277758811 0.333054760157132 no 2249 0.331084582730998 3197 25236586 SGTC_1845 st056753 3.01 µM -0.436973538495706 0.333035009430866 no 2250 0.33106526932275 3131 5375839 SGTC_1765 st044815 90.4 µM -0.438150935466504 0.332598512639243 no 2251 0.330638436513863 3250 645695 SGTC_3199 9111318 49.47 µM -0.438589474668747 0.332435990800641 no 2252 0.330479512458232 3232 8548020 SGTC_2113 5491891 107.031 µM -0.440129519154347 0.33186550278251 no 2253 0.329921651593445 3223 789979 SGTC_484 loperamide 105 µM -0.441079998496957 0.33151360529643 no 2254 0.329577541519627 3194 3955 An opioid-receptor agonist. SGTC_1321 1326-2144 215 µM -0.44117192345396 0.331479579652413 no 2255 0.329544268795394 3261 3513030 SGTC_1977 st070720 65.3 µM -0.441173535513542 0.33147898296761 no 2256 0.329543685313943 3272 682188 SGTC_333 3486-0131 40.1 µM -0.441399999411477 0.331395164283124 no 2257 0.329461721324251 3319 6744690 SGTC_2022 5136654 200 µM -0.441438062756569 0.331381077129096 no 2258 0.329447945876843 3282 1713771 SGTC_21 0849-0113 22.993 µM -0.442347347322361 0.331044624022163 no 2259 0.329118936926018 3210 1560156 SGTC_2099 5377090 177.372 µM -0.442869158062826 0.330851605396866 no 2260 0.328930188437362 3265 2243829 SGTC_971 1315-0384 26.7 µM -0.443124223135138 0.33075727277572 no 2261 0.328837942602734 3194 6769120 SGTC_583 1488-1091 88.9 µM -0.445031583924137 0.33005220030616 no 2262 0.328148464779939 3281 4303273 SGTC_3116 9124943 49.47 µM -0.445152473217516 0.330007532831519 no 2263 0.328104785091203 3197 41905195 YPL160W CDC60 SGTC_536 3852-0578 10.6 µM -0.445319105874451 0.329945967579958 no 2264 0.328044581275007 3316 2869208 SGTC_1054 3429-0080 167 µM -0.445862898658706 0.32974508619234 no 2265 0.327848141862736 3325 1162877 SGTC_2078 5212016 200 µM -0.446018081974207 0.329687769242056 no 2266 0.32779209225762 3223 1899708 SGTC_1400 3771-8998 51.5 µM -0.44616200271377 0.329634615698481 no 2267 0.327740113972812 3181 670767 SGTC_2203 7227154 166.4 µM -0.446901706070505 0.329361478986006 no 2268 0.327473016051781 3249 896304 SGTC_1424 4048-1941 275 µM -0.447531242106026 0.329129093438948 no 2269 0.327245767749401 3303 X1424 SGTC_1682 st012968 530 nM -0.449407485201317 0.328436893022825 no 2270 0.326568866317135 3166 24207270 SGTC_2414 st077232 92.9 µM -0.449437770448092 0.32842572473791 no 2271 0.326557944833704 3127 729801 SGTC_2839 9003951 25.97 µM -0.450129927941363 0.328170519752756 no 2272 0.326308379131371 3291 2990634 SGTC_2618 avocadyne 43.43 µM -0.451785545650981 0.327560403368821 no 2273 0.32571174183068 3207 3015189 SGTC_3258 9138477 49.47 µM -0.453531843670327 0.326917368783746 no 2274 0.325082909392271 3242 4970355 SGTC_2376 9072922 81.32 µM -0.453967908751879 0.326756877787808 no 2275 0.324925962342282 3329 17087968 SGTC_962 1254-0300 21.5 µM -0.455085376898524 0.326345747054088 no 2276 0.324523908903147 3195 7340576 SGTC_301 4119-0100 24.5 µM -0.455656266206492 0.326135790982736 no 2277 0.32431858772046 3232 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_298 1391-0729 10 µM -0.456138077809615 0.325958637905701 no 2278 0.324145345017927 3193 3237558 SGTC_819 1013-0258 27.7 µM -0.456366364420873 0.325874714918418 no 2279 0.324063274378991 3215 5753198 SGTC_605 1315-0399 119 µM -0.461254768793056 0.324079756881959 no 2280 0.322307915968317 3338 24020461 SGTC_285 1486-1325 46 µM -0.463725688073578 0.323174017976761 no 2281 0.321422145191831 3330 22310230 SGTC_1943 st076331 65.2 µM -0.465227311047897 0.32262409505111 no 2282 0.320884341306211 3331 24208415 SGTC_635 k038-0028 24.7 µM -0.466156619260262 0.322283958847337 no 2283 0.320551699123095 3233 4035102 SGTC_575 k072-0246 11.9 µM -0.466167326011175 0.322280040934456 no 2284 0.320547867523199 3279 6796779 SGTC_2097 5376186 200 µM -0.466374321109841 0.322204299263052 no 2285 0.320473794430863 3307 742755 SGTC_235 0330-0087 5 mM -0.467701863960963 0.321718713058537 no 2286 0.319998903978135 3275 46494818 YHR062C RPP1 SGTC_3126 9127922 49.47 µM -0.468834620834891 0.321304615923781 no 2287 0.319593925670807 3395 45595682 SGTC_1149 3909-7961 23.3 µM -0.469011751456126 0.321239883094611 no 2288 0.31953061813178 3262 735261 SGTC_92 0063-0024 660.874 µM -0.469161118281014 0.321185300834698 no 2289 0.319477237626119 3292 3594437 SGTC_3059 1327-0034 3 µM -0.471092238849544 0.320479970687651 no 2290 0.318787433613423 3225 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3039 9090270 49.47 µM -0.471386255385507 0.320372639687138 no 2291 0.318682464698234 3363 17173750 SGTC_2942 9052777 62.25 µM -0.471492307320115 0.320333929019525 no 2292 0.318644605919354 3268 6469503 SGTC_85 0868-0259 160.055 µM -0.472217726429195 0.320069191777449 no 2293 0.318385694125197 3254 83173 SGTC_3099 9120367 49.47 µM -0.474284215002736 0.319315541909814 no 2294 0.317648623148354 3294 24824940 SGTC_2369 9071472 200 µM -0.474559021056257 0.319215376072175 no 2295 0.317550660220739 3329 17296037 SGTC_2903 5923464 63.88 µM -0.474835949679683 0.31911444991384 no 2296 0.317451953561976 3330 2876576 SGTC_1072 oxiconazole 14.9 nM -0.4755507960619 0.318853987367833 no 2297 0.317197218317442 3330 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_15 0266-0086 27.098 µM -0.476713773156065 0.318430434375136 no 2298 0.316782976914061 3351 1712902 YIL048W NEO1 SGTC_3006 9075424 71.4286 µM -0.477251183620546 0.318234791089438 no 2299 0.316591633941892 3238 7465181 SGTC_309 k408-0051 1.48 µM -0.477318247014374 0.318210380341694 no 2300 0.316567759715928 3311 3640463 SGTC_1930 st074634 34.3 µM -0.47865056379432 0.317725587300507 no 2301 0.316093620250426 3208 684253 YOR116C RPO31 SGTC_1360 1598-0022 39.8 µM -0.478965345110173 0.317611092712835 no 2302 0.315981641279135 3332 761525 SGTC_1953 st076800 12.1 µM -0.479257740767562 0.317504756027724 no 2303 0.315877640810533 3253 297591 SGTC_1115 galangin 695.678 nM -0.47938503660928 0.317458466549502 no 2304 0.315832368264123 3391 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1409 3909-8004 61.9 µM -0.479636250764714 0.317367124162579 no 2305 0.315743032489412 3285 2119279 SGTC_1531 st059297 52.4 µM -0.48049959186867 0.317053294988957 no 2306 0.315436096658759 3340 7566702 SGTC_2320 7373003 200 µM -0.480932326938774 0.316896042921298 no 2307 0.315282298169018 3304 5415828 SGTC_2134 5324836 1.464 µM -0.481646525314937 0.316636581939101 no 2308 0.315028534738748 3215 699272 SGTC_368 fentichlor 4.58 µM -0.484337202731359 0.315659897092976 no 2309 0.314073288705525 3283 7329 A pesticide. SGTC_2382 9035899 200 µM -0.486383144113629 0.31491810420662 no 2310 0.31334776961856 3256 6462679 SGTC_1293 1000-1278 195 µM -0.487421339163087 0.314541973017033 no 2311 0.312979887156319 3383 678847 SGTC_2290 7904846 200 µM -0.487506395287388 0.314511166268589 no 2312 0.312949755923163 3308 2962154 SGTC_527 4476-4215 268 µM -0.488483072289928 0.314157513117044 no 2313 0.312603856515841 3243 4418754 SGTC_1019 4262-0212 3.4 µM -0.490221015520105 0.313528628643847 no 2314 0.311988755627119 3357 4677213 SGTC_2420 aureobasidin a 50 nM -0.490856098723148 0.313298955263045 no 2315 0.31176411465804 3464 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_711 k292-0785 179 µM -0.494498967846512 0.311982937968624 no 2316 0.310476917557654 3286 4146315 SGTC_3343 9148379 18.9835 µM -0.494680265090853 0.311917505269746 no 2317 0.310412917118853 3408 1955036 SGTC_1399 3562-5772 25 µM -0.494979086579216 0.311809669389688 no 2318 0.310307441521003 3286 23847490 SGTC_2499 avocadenofuran 51.48 µM -0.495744189742745 0.311533639724359 no 2319 0.310037452700896 3228 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3076 9116187 49.47 µM -0.496624373762307 0.311216222804689 no 2320 0.309726980918131 3332 27241210 SGTC_1908 st060353 56.5 µM -0.496733210631646 0.311176983184262 no 2321 0.309688599758494 3448 4227716 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.497674080543587 0.310837855113851 no 2322 0.309356889924761 3257 6857784 SGTC_2163 5671233 125 µM -0.498539488183596 0.310526068532199 no 2323 0.309051921905854 3463 701023 SGTC_346 4513-0042 7.16 µM -0.50034604661044 0.309875645528496 no 2324 0.308415718254632 3291 2827372 SGTC_2692 st077426 47.7 µM -0.500886501310827 0.309681178766407 no 2325 0.308225501553639 3407 25238571 SGTC_3088 9117578 49.47 µM -0.501188867145778 0.309572404525089 no 2326 0.308119104302469 3401 678341 SGTC_2653 dihydrofissinolide 100 µM -0.502134285304602 0.309232403816531 no 2327 0.307786532229929 3375 6857746 SGTC_2840 9008771 71.43 µM -0.503315330105695 0.30880789413565 no 2328 0.307371294974135 3307 2992978 SGTC_2988 9073640 71.4286 µM -0.503591096799332 0.308708810483168 no 2329 0.3072743751491 3445 9102229 SGTC_830 4076-0286 57.8 µM -0.504138890356827 0.308512028214957 no 2330 0.30708188981051 3358 6866659 SGTC_3180 9109287 49.47 µM -0.50451972904061 0.308375253056014 no 2331 0.30694810089249 3375 18891271 SGTC_3119 9125183 49.47 µM -0.505435937228924 0.308046313209796 no 2332 0.306626341591543 3256 22695334 SGTC_1942 st076330 65.2 µM -0.505564731862645 0.308000085320585 no 2333 0.306581122683392 3426 24208414 SGTC_2792 7535235 81.82 µM -0.505652964299193 0.307968418062988 no 2334 0.306550146582454 3291 1281891 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.506860754541893 0.30753507727275 no 2335 0.306126262027967 3316 688761 SGTC_1201 1889-3372 45.9 µM -0.50752091982265 0.3072983312386 no 2336 0.305894680864617 3267 5392199 SGTC_1184 1269-1718 139 µM -0.507521135282098 0.307298253984428 no 2337 0.305894605295675 3411 5403821 SGTC_2391 6285546 200 µM -0.509518063967456 0.306582611875206 no 2338 0.305194569917584 3285 846083 SGTC_1761 st044296 37 µM -0.509637531985898 0.306539821289593 no 2339 0.305152712232767 3285 1826700 SGTC_338 4055-0136 114 µM -0.510014264942016 0.306404901832504 no 2340 0.305020734022359 3295 2900563 SGTC_509 pifithrin 175 µM -0.510291266494882 0.30630571594435 no 2341 0.304923710188867 3410 4817 A p53 inhibitor. SGTC_3172 9105863 49.47 µM -0.510992331070952 0.306054749325337 no 2342 0.304678213384321 3334 2348785 SGTC_389 tpck 16.7 µM -0.512174527720358 0.305631753540989 no 2343 0.304264434317909 3355 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1511 0906-3109 28.5 µM -0.512822118499065 0.305400152236982 no 2344 0.30403787808776 3378 2882180 SGTC_1744 st037937 38.9 µM -0.513434613742961 0.305181173980237 no 2345 0.303823669066638 3437 1016152 SGTC_2781 5567276 71.43 µM -0.514333583395394 0.304859902149698 no 2346 0.303509392845141 3413 2853274 SGTC_1583 clindamycin 39.6 µM -0.516071097067091 0.304239379656231 no 2347 0.302902376878612 3297 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2850 9015429 58.44 µM -0.517232797894302 0.303824812683011 no 2348 0.302496829685727 3332 6457570 SGTC_1981 st071826 47 µM -0.518796185150626 0.303267297211591 no 2349 0.30195143924124 3355 11838600 SGTC_3176 9106582 49.47 µM -0.519811229269084 0.302905570003373 no 2350 0.301597575961796 3327 17018027 SGTC_2266 7929956 200 µM -0.52091415784836 0.302512742860076 no 2351 0.301213286133444 3406 2967153 SGTC_1645 Cervolide 78 µM -0.521621395605411 0.302260968105779 no 2352 0.300966981700409 3371 23173 A fragrance. SGTC_3273 9137859 49.47 µM -0.521856579409633 0.30217726413646 no 2353 0.300885096110038 3414 2377234 SGTC_2627 acetyl isogambogic acid 100 µM -0.523632130663563 0.301545666025194 no 2354 0.300267214567552 3371 6857789 A caspase activator and apoptosis inducer. SGTC_1473 k844-0725 134 µM -0.523732792927375 0.301509876297267 no 2355 0.300232201869511 3441 54682906 SGTC_2334 9017922 200 µM -0.526453651421662 0.300543220060398 no 2356 0.299286523491969 3383 3163164 SGTC_648 0375-0473 33.3 µM -0.527350108709237 0.300225036914331 no 2357 0.298975241479008 3352 1713139 SGTC_1197 1601-0112 267 µM -0.529766271672995 0.299368217959212 no 2358 0.298136996479473 3315 7350313 SGTC_3127 9126946 49.47 µM -0.529916305206661 0.299315049702169 no 2359 0.298084980321658 3341 27243249 SGTC_589 1227-0070 34.1 µM -0.530547936968721 0.299091261664925 no 2360 0.297866040922993 3437 2841384 SGTC_839 0122-0028 230 µM -0.530905931607728 0.298964457387413 no 2361 0.297741983575929 3321 759448 SGTC_1503 4585-0012 61.3 µM -0.531072003613679 0.298905641779658 no 2362 0.297684441968752 3444 2922052 SGTC_776 4476-4378 112 µM -0.531373695773968 0.298798808758932 no 2363 0.297579922875343 3411 2892008 SGTC_2029 5175081 200 µM -0.531588017393932 0.298722925298744 no 2364 0.29750568285973 3385 1380876 SGTC_1814 st052110 31.539 µM -0.532141269980247 0.298527079266212 no 2365 0.297314077830892 3429 674163 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.534281719765658 0.297769931590167 no 2366 0.29657331882286 3429 364106 SGTC_2121 5257820 149.641 µM -0.534481838898918 0.297699187652278 no 2367 0.296504105568722 3455 791256 SGTC_2304 7443016 91.4 µM -0.536378046407524 0.297029241946077 no 2368 0.295848650424839 3375 939854 SGTC_813 k007-0158 173 µM -0.53957673261025 0.295900685342747 no 2369 0.294744483107529 3383 6523916 SGTC_1120 ficusin 1.78878 µM -0.542998413883435 0.294695636410881 no 2370 0.293565447250658 3431 6199 A DNA cross-linker. SGTC_2366 9070441 60.58 µM -0.543017716747648 0.294688844745751 no 2371 0.293558802108554 3350 6837235 SGTC_308 4092-1169 104 µM -0.543054126567527 0.294676034237001 no 2372 0.293546267970378 3389 2268590 YDL196W YDL196W SGTC_2961 9083290 32.55 µM -0.543947672745176 0.294361727575219 no 2373 0.293238740983866 3429 17741490 SGTC_655 k060-0012 42 µM -0.545532122599823 0.293804775099932 no 2374 0.292693796924313 3351 5994525 SGTC_2138 5575593 77.673 µM -0.547387396092061 0.293153245342191 no 2375 0.292056306260928 3381 762213 SGTC_625 k213-0058 121 µM -0.54739577906894 0.293150302952847 no 2376 0.29205342725296 3448 3655420 SGTC_67 0335-0847 266 µM -0.547763051742791 0.293021405247046 no 2377 0.291927305919511 3549 4552207 YOR254C SEC63 SGTC_1752 st044819 83.042 µM -0.548515190601525 0.292757517324639 no 2378 0.291669100837236 3343 441209 YML126C ERG13 SGTC_573 3702-0553 84.7 µM -0.549907028744826 0.29226948218098 no 2379 0.291191571524149 3443 1222756 SGTC_2080 5212524 12.4 µM -0.55136630612186 0.291758206849387 no 2380 0.290691296657763 3453 260183 SGTC_1267 0828-0272 9.49 µM -0.552605985191145 0.291324198104405 no 2381 0.290266621356551 3504 745334 SGTC_2987 9018338 71.43 µM -0.55391206970637 0.290867267176053 no 2382 0.289819512244879 3502 5055682 SGTC_2431 5490079 200 µM -0.55511793726886 0.290445694597118 no 2383 0.289406997258375 3396 5722345 SGTC_1302 1159-0335 255 µM -0.557430438169807 0.289638043007736 no 2384 0.288616686932455 3397 649284 SGTC_1461 k072-0203 53.8 µM -0.557646494263565 0.289562638303234 no 2385 0.288542900493398 3387 5418714 SGTC_1828 st055811 49 µM -0.558683426006207 0.289200872049923 no 2386 0.28818889630004 3444 5877589 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.559712687696399 0.2888419920036 no 2387 0.287837713382042 3459 66535 A nucleotide analog. SGTC_2338 7999974 200 µM -0.559774446090571 0.288820464929915 no 2388 0.287816647917655 3475 315925 SGTC_2734 clemastine 41.6 µM -0.559862138626703 0.288789899310877 no 2389 0.287786737704616 3382 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1655 st012546 55.1 µM -0.559974328508825 0.288750797254724 no 2390 0.287748474065912 3429 720985 YLR208W SEC13 SGTC_2703 st077852 53.4 µM -0.560188042002093 0.288676317605011 no 2391 0.287675591292994 3458 6281836 SGTC_785 1270-0111 65.3 µM -0.560193231386685 0.288674509204926 no 2392 0.287673821664194 3449 6741994 SGTC_390 dec-rvkr-cmk 16.7 µM -0.561288285458739 0.288293023463956 no 2393 0.287300513089602 3425 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1107 amlodipine 47 µM -0.564660991967517 0.287119564492565 no 2394 0.286152185675104 3406 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1846 st056244 14.8 µM -0.565360864729387 0.286876342799424 no 2395 0.285914168858758 3421 5393182 SGTC_2754 granisetron 64.02 µM -0.565785575968512 0.286728793605803 no 2396 0.285769776482576 3497 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2358 9037157 4 µM -0.568693251824567 0.285719603727579 no 2397 0.284782164078026 3448 2388925 SGTC_3164 9100705 49.47 µM -0.569531270126423 0.285429060129653 no 2398 0.284497827973692 3510 17174235 SGTC_3243 9134147 49.47 µM -0.569705319406829 0.285368734341726 no 2399 0.284438790791921 3499 24282180 SGTC_350 k064-0020 19.8 µM -0.569748272189891 0.285353847765532 no 2400 0.28442422219087 3486 2790705 SGTC_1247 0448-0043 5.84 µM -0.570582711489383 0.285064721196149 no 2401 0.284141270238151 3456 3089013 YGL099W LSG1 SGTC_2351 9026858 72.31 µM -0.571102696301321 0.284884621264302 no 2402 0.283965015492635 3389 1409300 SGTC_3040 9091894 49.47 µM -0.571746929710246 0.284661562382031 no 2403 0.283746717865588 3409 25236966 SGTC_1998 st075797 76.8 µM -0.572203864605069 0.284503404151951 no 2404 0.283591934816659 3495 24208315 SGTC_719 2810-4230 27.3 µM -0.572332046275774 0.284459044351142 no 2405 0.283548521565534 3438 721079 SGTC_2737 bleomycin 30.5 nM -0.573463134333339 0.284067752260837 no 2406 0.283165576733266 3479 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_523 1934-0222 13.7 µM -0.573510171053311 0.284051485810595 no 2407 0.283149657204673 3420 1361595 SGTC_2265 7929201 200 µM -0.57459894719771 0.283675084928664 no 2408 0.282781282125363 3418 1265108 SGTC_773 4358-1457 44.6 µM -0.575869681396311 0.283236081669523 no 2409 0.282351634977631 3504 1186886 SGTC_224 benfluorex 43.875 µM -0.57762223286796 0.282631159151756 no 2410 0.281759596623159 3491 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1733 st037357 54.9 µM -0.579195370065918 0.282088693890328 no 2411 0.281228677262154 3433 1272339 YGL099W LSG1 SGTC_1249 0481-0015 10.2 µM -0.579538866248043 0.281970312739926 no 2412 0.281112814740314 3407 4227577 SGTC_884 0851-0618 334 µM -0.58075830598704 0.281550243286063 no 2413 0.280701679572199 3496 9642473 SGTC_3070 9117005 49.47 µM -0.58198934520541 0.281126484488551 no 2414 0.280286928859654 3517 8779016 SGTC_472 calcifediol 10 µM -0.584169405923405 0.280376802153067 no 2415 0.279553171380111 3468 5283731 A vitamin D metabolite. SGTC_1154 4088-0362 150 µM -0.585296007544704 0.279989764558279 no 2416 0.279174349459425 3499 6618304 SGTC_579 4491-1009 110 µM -0.585685716983572 0.279855942415317 no 2417 0.279043367038779 3595 1271041 SGTC_236 1509-0011 5.31 µM -0.586573602068876 0.27955116787586 no 2418 0.278745058062499 3559 3107280 SGTC_1381 2324-0066 62.1 µM -0.586619684293991 0.279535354137646 no 2419 0.27872957973284 3482 10885928 SGTC_204 PMA1.184 62.41 µM -0.586702898899056 0.279506799021887 no 2420 0.278701630252551 3492 2252213 YGL008C PMA1 SGTC_2213 7173844 200 µM -0.589877072781665 0.278418639101685 no 2421 0.277636533073864 3462 892728 SGTC_3077 9117319 49.47 µM -0.590726451269029 0.278127808444666 no 2422 0.27735186089951 3509 17154678 SGTC_2611 pyromycin 23.93 µM -0.592244800884461 0.277608288828605 no 2423 0.276843336587259 3443 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_396 dithiazanine 1.25 µM -0.59292552341833 0.277375526335785 no 2424 0.276615497949119 3427 10578 An antihelmenthic. SGTC_2388 9080168 200 µM -0.593630810522721 0.277134465061862 no 2425 0.276379534498719 3452 15943073 SGTC_1768 st044301 37.178 µM -0.594181382886062 0.276946355275708 no 2426 0.276195401626154 3450 3931349 SGTC_1443 4112-3303 14 µM -0.595871274973088 0.276369373670627 no 2427 0.275630612080649 3500 704433 SGTC_850 0388-0143 75.9 µM -0.595889501070437 0.276363153930718 no 2428 0.275624523717702 3453 67273 SGTC_233 rapamycin 362 pM -0.598298710081474 0.275541605158111 no 2429 0.274820318576695 3516 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_909 3448-9333 149 µM -0.598602178388581 0.275438206632703 no 2430 0.274719101531081 3476 3344074 SGTC_1290 0986-0249 10.2 µM -0.59880872330915 0.275367843019319 no 2431 0.274650222259906 3481 53329 SGTC_1105 epirubicin 18.1 µM -0.600591250117123 0.274760957821499 no 2432 0.274056133618196 3431 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1777 st045864 34.765 µM -0.600801458835701 0.274689432930769 no 2433 0.273986116178776 3530 4691462 SGTC_508 roscovitine 141 µM -0.602523134749273 0.274103967244803 no 2434 0.273412984158485 3523 160355 A CDKinase inhibitor. SGTC_905 2-aminofluorene 215 µM -0.6032840649121 0.27384540520855 no 2435 0.273159865936672 3564 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1153 4055-0057 267 µM -0.604243638462801 0.273519516704523 no 2436 0.272840835976994 3452 882706 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.605513640660132 0.273088496386946 no 2437 0.272418881999713 3559 165521 SGTC_427 1354-0053 47.3 µM -0.605967118474682 0.27293467419977 no 2438 0.272268294078834 3597 6813657 SGTC_479 n-linoleoylglycine 10 µM -0.609900375024583 0.271602296941866 no 2439 0.270963902039985 3487 6433346 An anti-infammatory. SGTC_3207 9114163 49.47 µM -0.610287017035296 0.271471498318878 no 2440 0.270835847850214 3611 849233 SGTC_1832 st054113 55 µM -0.610702191091557 0.271331082425038 no 2441 0.27069837760758 3538 1251267 SGTC_245 methotrexate 289.6 µM -0.611106250584058 0.271194460347825 no 2442 0.270564621024374 3516 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3326 9140064 16.379 µM -0.612814655315913 0.270617187619913 no 2443 0.269999449707178 3512 1868434 SGTC_61 0978-8327 98.565 µM -0.613415454737709 0.27041432248952 no 2444 0.269800834849653 3557 6150059 YHR072W ERG7 SGTC_849 0386-0493 241 µM -0.615861491665065 0.269589182338842 no 2445 0.268992969418958 3468 726119 SGTC_2838 9002687 71.43 µM -0.616158638706976 0.269489029481353 no 2446 0.268894911886609 3506 6457060 SGTC_2204 7233102 200 µM -0.618869325792261 0.268576259307013 no 2447 0.268001223693558 3480 2172480 SGTC_2010 4012422 159 µM -0.619665530761754 0.268308448598816 no 2448 0.267739006792288 3492 952393 SGTC_1663 st014140 55.4 µM -0.620795365512817 0.267928649205718 no 2449 0.267367136471791 3610 4207120 SGTC_450 aminopyrene 156 nM -0.621740573809422 0.26761112101523 no 2450 0.267056233827668 3532 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1638 st008370 60.6 µM -0.621898392338762 0.267558122793921 no 2451 0.267004341157211 3553 24207134 SGTC_1191 1487-1166 10.6 µM -0.623454790517749 0.267035740661454 no 2452 0.266492851222438 3576 3955771 SGTC_2244 6635614 200 µM -0.62364614479242 0.266971550987637 no 2453 0.266429999369019 3427 836499 SGTC_2591 skatole 100 µM -0.623954554804826 0.266868111443361 no 2454 0.266328715401339 3558 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_349 k015-0014 24 µM -0.624115139724064 0.266814259890315 no 2455 0.26627598592538 3515 2196908 SGTC_3094 9117742 49.47 µM -0.624683704158876 0.266623638079089 no 2456 0.266089335256663 3519 17149698 SGTC_3156 9099931 49.47 µM -0.625166023723821 0.26646198546556 no 2457 0.265931049369526 3530 18111053 SGTC_1963 st076565 50.3 µM -0.626452520305194 0.266031050192645 no 2458 0.265509085042739 3566 4914280 SGTC_2555 cholic acid 100 µM -0.626751933880727 0.265930806868665 no 2459 0.265410927663375 3572 6708657 Influences liver metabolism. SGTC_620 0109-0052 432 µM -0.626865660466606 0.265892736353096 no 2460 0.265373649264861 3577 493037 SGTC_3108 9121785 49.47 µM -0.627122408302015 0.265806798950457 no 2461 0.265289499752681 3530 17140271 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.627833194657131 0.265568961412763 no 2462 0.265056609072909 3585 65057 A dermal irritant. YDR527W RBA50 SGTC_1006 4099-6547 255 µM -0.628055011016597 0.265494761135462 no 2463 0.264983951734356 3572 3146833 SGTC_272 doxorubicin 8.13 µM -0.628132464614258 0.265468854440227 no 2464 0.264958583707089 3578 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_559 1550-0661 158 µM -0.628367519500982 0.265390241086891 no 2465 0.264881604797219 3556 5830875 SGTC_2469 5655019 90.81 µM -0.629440478126124 0.265031543627812 no 2466 0.264530362426568 3604 2788239 SGTC_2052 5265182 7.135 µM -0.630287930977741 0.264748408499599 no 2467 0.264253108941563 3551 1239884 SGTC_1229 0139-0193 12.2 µM -0.630350858850394 0.264727390349332 no 2468 0.264232527302126 3604 3090752 SGTC_1028 k015-0029 4.8 µM -0.631204414740765 0.264442383249985 no 2469 0.263953437874719 3567 4588309 SGTC_1027 k015-0025 8.67 µM -0.631385051745041 0.264382087568662 no 2470 0.263894393784174 3556 3598955 SGTC_3183 9108214 49.47 µM -0.632203665962354 0.264108926199193 no 2471 0.263626901070912 3498 4974831 SGTC_118 0083-0097 135.343 µM -0.632283605766848 0.264082258989996 no 2472 0.263600787128422 3650 5207356 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.632851217137564 0.263892948335996 no 2473 0.263415403439446 3552 6312947 SGTC_3120 9124077 49.47 µM -0.632924992428561 0.263868347764004 no 2474 0.26339131308198 3589 18774327 YGL155W CDC43 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.633165237347861 0.263788245544061 no 2475 0.263312872038301 3590 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2294 7971431 200 µM -0.6337773718291 0.263584204342627 no 2476 0.263113061320077 3521 5741572 SGTC_222 nsc-310342 10.666 µM -0.634566533690199 0.263321273947202 no 2477 0.262855580336961 3535 432556 SGTC_403 arphamenine a 50 µM -0.634898018433236 0.263210870890976 no 2478 0.262747464770216 3543 5487158 An arginine aminopeptidase inhibitor. SGTC_2893 9048488 25.97 µM -0.636916680058757 0.262539053894796 no 2479 0.262089558617282 3522 6467338 SGTC_3007 9078383 71.4286 µM -0.636939631649097 0.262531420581907 no 2480 0.262082083274623 3550 6496995 SGTC_727 3032-0951 202 µM -0.636968165704614 0.262521930793408 no 2481 0.262072789873082 3537 3652836 SGTC_2076 5212012 200 µM -0.63718883629796 0.262448546621043 no 2482 0.262000924250722 3492 604802 SGTC_1616 st002734 56.1 µM -0.637758500130157 0.26225915304678 no 2483 0.261815448984262 3541 4026101 SGTC_151 3013-0144 2.285 µM -0.637780018268183 0.26225200038064 no 2484 0.261808444273692 3558 906558 YHR107C CDC12 SGTC_1131 3454-3128 32.3 µM -0.638473225316715 0.262021630640942 no 2485 0.261582838888899 3561 710982 SGTC_653 0203-0016 55.2 µM -0.639351719221188 0.26172983463085 no 2486 0.261297075018108 3558 295302 SGTC_2806 7952793 58.44 µM -0.63959999252986 0.261647399674892 no 2487 0.261216343668518 3579 2972490 SGTC_931 2812-0076 566 µM -0.639813437580973 0.261576539506487 no 2488 0.261146947715445 3585 3450959 SGTC_2468 5987765 72.9 µM -0.640302491261386 0.261414219056302 no 2489 0.260987980717378 3576 26772094 SGTC_726 3448-4391 34.2 µM -0.641273699406252 0.26109202148983 no 2490 0.26067243689872 3667 1356692 SGTC_982 1491-0518 27.5 µM -0.642696367778865 0.260620421123744 no 2491 0.260210569170095 3538 3091256 SGTC_181 1447-1644 8.07 µM -0.64270351073951 0.26061805441035 no 2492 0.260208251280284 3544 534600 SGTC_2677 mitomycin C 100 µM -0.643445810634456 0.26037216474666 no 2493 0.259967433084054 3596 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1567 st069303 68.4 µM -0.643476144000917 0.260362119245743 no 2494 0.259957594726694 3605 5581319 SGTC_145 3737-0113 38.366 µM -0.643967341087859 0.260199477304825 no 2495 0.259798306060581 3614 6849351 SGTC_258 haloperidol 50.781 µM -0.64620328423108 0.259459788784333 no 2496 0.259073856441169 3550 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3171 9103192 49.47 µM -0.647562878303705 0.259010543210227 no 2497 0.258633856752317 3631 13018434 SGTC_2508 celastrol 40.54 µM -0.647575798136371 0.259006276088731 no 2498 0.258629677417958 3552 122724 Celastrol is a natural product and antioxidant. SGTC_94 0334-0113 514.748 µM -0.64827129702995 0.258776622582772 no 2499 0.258404747604382 3537 6795178 SGTC_2622 2-methoxyxanthone 59.94 µM -0.649380995273248 0.258410418920095 no 2500 0.258046072435231 3601 71034 A hepatoprotective. SGTC_1488 4013-0813 75.9 µM -0.649637947611265 0.258325662195382 no 2501 0.25796305747785 3571 2910057 SGTC_1251 0490-5699 265 µM -0.650316400729199 0.25810194105962 no 2502 0.257743932624826 3636 3883818 SGTC_1339 1486-1321 22.7 µM -0.652454147889349 0.257397672680205 no 2503 0.257054121523452 3604 3469382 SGTC_911 3456-4043 236 µM -0.653542951026369 0.257039356994467 no 2504 0.25670315451776 3654 914281 SGTC_1632 st005650 90 µM -0.653801159491748 0.256954420899409 no 2505 0.25661995969235 3583 2759605 SGTC_3008 9078912 71.4286 µM -0.654247756368208 0.256807550065303 no 2506 0.256476099230969 3595 16648731 SGTC_1690 st023502 41.2 µM -0.654737133000117 0.256646660582549 no 2507 0.256318506558408 3591 24207482 SGTC_2195 6536160 144.242 µM -0.657108361256335 0.255867829746692 no 2508 0.255555621512196 3493 3834386 SGTC_87 0100-0052 35.5 µM -0.658515183449984 0.255406342133303 no 2509 0.255103571901246 3680 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3332 9141069 11.198 µM -0.660357612093417 0.254802618649172 no 2510 0.254512183437407 3589 17332883 SGTC_130 0136-0219 337.655 µM -0.661046417030485 0.254577104374607 no 2511 0.254291273300089 3578 234244 SGTC_1130 3454-2858 15.9 µM -0.661211317517357 0.254523131580983 no 2512 0.254238402142835 3573 715628 YIL048W NEO1 SGTC_2859 9028643 45.46 µM -0.661666384370569 0.254374216920337 no 2513 0.254092526408665 3583 17151580 SGTC_3227 9130768 49.47 µM -0.664138126769097 0.253566169955708 no 2514 0.253300954893418 3617 17720899 SGTC_2449 5812982 45.77 µM -0.664848139392635 0.253334306512219 no 2515 0.253073814422067 3594 776185 SGTC_1127 asiatic acid 681.4 nM -0.666165431028817 0.25290442395454 no 2516 0.252652683020408 3608 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_662 k832-1615 104 µM -0.666553321835109 0.252777913585333 no 2517 0.252528746695246 3606 5878478 SGTC_807 1315-0151 48 µM -0.667847801403672 0.252355961059207 no 2518 0.252115375011391 3662 4011080 SGTC_815 1582-0027 36.9 µM -0.668065938139921 0.252284893113331 no 2519 0.252045751635433 3644 3128206 SGTC_2309 7664088 163.95 µM -0.669283655195347 0.251888360446876 no 2520 0.251657275570314 3640 704922 SGTC_2263 7948595 193.29 µM -0.670235604157251 0.251578600737836 no 2521 0.251353805227913 3619 2971371 SGTC_430 0958-0115 16.4 µM -0.670385339419678 0.251529895911538 no 2522 0.251306088967946 3600 6833180 SGTC_2733 amorolfine 100 µM -0.67072202763991 0.251420398548737 no 2523 0.251198813747851 3635 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1492 4158-0558 28.5 µM -0.672678519413044 0.250784609389477 no 2524 0.250575918111234 3622 3967268 SGTC_1772 st048439 82.2 µM -0.672953152515937 0.250695431733025 no 2525 0.250488547678597 3602 2927068 YDL195W SEC31 SGTC_2303 7774051 200 µM -0.674412194000065 0.250221939940276 no 2526 0.250024646186762 3634 2953184 SGTC_1049 3226-0134 66 µM -0.674531473322664 0.250183252096952 no 2527 0.249986741554396 3668 5702385 SGTC_879 0831-1030 162 µM -0.674572309809093 0.250170007650242 no 2528 0.249973765219622 3660 1549252 SGTC_2300 7976697 71.57 µM -0.674687870580619 0.250132529984598 no 2529 0.249937046189992 3567 2236109 SGTC_2019 4016004 108 µM -0.676948635985082 0.249399937617997 no 2530 0.249219272083355 3608 45595336 SGTC_1721 st082152 9.2685 µM -0.677488696229278 0.249225102074565 no 2531 0.249047969823776 3616 5296051 SGTC_2224 6650123 117.647 µM -0.677921526361636 0.249085027564819 no 2532 0.24891072522854 3610 2908370 SGTC_668 1682-0499 62.6 µM -0.677997544283842 0.249060430614164 no 2533 0.248886625127527 3662 682214 SGTC_1416 3966-0321 25.3 µM -0.678294862170648 0.248964240536487 no 2534 0.24879237782357 3650 582530 YLR208W SEC13 SGTC_1005 4092-0690 4.4 µM -0.678336963329342 0.248950621313568 no 2535 0.248779033641488 3633 1529343 SGTC_320 4092-0846 5.34 µM -0.679415777396649 0.248601773113286 no 2536 0.248437227920459 3620 1359356 SGTC_2104 5389443 200 µM -0.67963755684758 0.248530090199544 no 2537 0.248366991524065 3679 2244536 SGTC_991 3996-0057 64.7 µM -0.680145946687276 0.248365811469128 no 2538 0.248206027060376 3637 715343 SGTC_1502 4534-4282 27.7 µM -0.680256326153078 0.248330151610889 no 2539 0.248171086484309 3629 3278949 SGTC_1778 st046819 58.9 µM -0.680801585223405 0.248154036966911 no 2540 0.24799852343542 3684 671715 SGTC_419 nsc-638432 893 µM -0.68154045501738 0.247915493829914 no 2541 0.247764788857655 3637 368090 SGTC_2171 5739187 198.077 µM -0.681640692780288 0.247883141630768 no 2542 0.247733088638181 3601 2262761 SGTC_1610 st001799 48.1 µM -0.68358124469133 0.247257263916494 no 2543 0.247119815619797 3584 621897 SGTC_2937 9044753 11.33 µM -0.684316076826444 0.247020482468891 no 2544 0.246887798617424 3662 6465530 YGL099W LSG1 SGTC_1807 st050092 58.9 µM -0.684652609529432 0.246912083660204 no 2545 0.246781580213758 3618 5008496 SGTC_741 4582-0002 126 µM -0.684657984475882 0.246910352570569 no 2546 0.246779883940505 3628 2912688 SGTC_1288 0973-0013 65.5 µM -0.684843771874305 0.246850520685326 no 2547 0.246721255343316 3676 4315430 SGTC_2585 alliin 100 µM -0.68559453506776 0.24660882028934 no 2548 0.246484414328943 3725 87310 A garlic compound which reacts with lipids. SGTC_1771 st048882 4.1505 µM -0.685984557875388 0.246483306555607 no 2549 0.246361423101537 3639 4580403 SGTC_2511 berberine 10.47 µM -0.686409882108563 0.24634647145096 no 2550 0.246227337296637 3656 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2505 galangin 7.89 µM -0.687772264527945 0.245908440683577 no 2551 0.245798102285877 3585 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_221 trifluoperazine 10.304 µM -0.687801850382813 0.245898932931573 no 2552 0.24578878536385 3663 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_197 4544-0043 41.561 µM -0.688153569123373 0.245785919216512 no 2553 0.245678039659283 3650 896523 SGTC_2122 5258151 111.688 µM -0.689736796810997 0.245277544415302 no 2554 0.245179860603639 3654 2173356 SGTC_870 0573-2213 57.6 µM -0.689748626825405 0.245273747923593 no 2555 0.245176140212311 3658 3916321 SGTC_260 nsc-65238 3.989 µM -0.690520334065951 0.245026159667504 no 2556 0.244933513546012 3601 3246252 SGTC_1464 k208-0027 110 µM -0.691743701460031 0.244633940121063 no 2557 0.244549148709814 3676 X1464 SGTC_1458 k015-0034 6.33 µM -0.692549385187044 0.244375817450651 no 2558 0.244296191763585 3652 3598957 SGTC_1002 4049-0206 172 µM -0.693513030551853 0.244067280338896 no 2559 0.243993825623552 3694 4662749 SGTC_2194 5927483 104.545 µM -0.694076864361233 0.243886851181107 no 2560 0.243817003320767 3685 760979 SGTC_736 0958-0254 92.6 µM -0.694692645753722 0.24368988083971 no 2561 0.243623968926279 3717 6812352 SGTC_900 1112-0045 141 µM -0.696485832337031 0.243116782786236 no 2562 0.243062313392266 3592 56211 YIL048W NEO1 SGTC_2470 5664817 21.68 µM -0.696625505679948 0.243072174141913 no 2563 0.243018594820379 3691 2859561 SGTC_3165 9101544 49.47 µM -0.697128578836437 0.242911540149045 no 2564 0.242861165239112 3664 5002184 SGTC_1271 0832-2808 169 µM -0.697739008688493 0.242716703732502 no 2565 0.242670214039692 3689 3663794 SGTC_11 0438-0307 1.3 µM -0.698609321573548 0.242439064448596 no 2566 0.242398108323521 3662 4011476 SGTC_1888 azatryptophan 97.5 µM -0.699914236177237 0.242023105058955 no 2567 0.241990433117922 3643 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_637 1181-0519 7.26 µM -0.70029082311897 0.241903134824967 no 2568 0.241872850804358 3689 6252091 YGR060W ERG25 SGTC_354 2783-3500 4.88 µM -0.70092425572834 0.241701413425206 no 2569 0.241675143117277 3663 6740761 SGTC_2032 5185112 25.99 µM -0.705356852153601 0.240292378042586 no 2570 0.24029409426763 3613 5718189 SGTC_1659 st012954 42.1 µM -0.70554635509033 0.240232238701599 no 2571 0.240235147487498 3659 24207262 SGTC_486 niguldipine 82 µM -0.707486254301049 0.239617077701867 no 2572 0.239632175921529 3696 1236 A calcium channel blocker. SGTC_18 0111-0177 500 nM -0.708308626787089 0.239356555091217 no 2573 0.239376810511987 3773 721752 SGTC_706 4262-0057 46.9 µM -0.708417765326197 0.239321992297152 no 2574 0.23934293168204 3675 883298 SGTC_1477 0139-0234 16 µM -0.708765069076378 0.239212023739083 no 2575 0.239235138940471 3693 620880 SGTC_1233 0325-0408 14.2 µM -0.709341188233081 0.239029665097612 no 2576 0.239056387221372 3720 12874 SGTC_1489 4065-0444 182 µM -0.710262340683064 0.238738251248866 no 2577 0.238770734238939 3659 2877968 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.712053345163818 0.238172209629956 no 2578 0.238215871611026 3671 97141 SGTC_704 1310-0270 142 µM -0.713327722257759 0.23776989475041 no 2579 0.237821493422009 3676 5718033 SGTC_412 gemfibrozil 100 µM -0.713824536657675 0.237613153814983 no 2580 0.237667842616506 3674 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1967 st070177 51.4 µM -0.714118822292466 0.237520335817219 no 2581 0.237576853988833 3730 5729214 SGTC_751 0833-0568 350 µM -0.715145942911219 0.237196536888681 no 2582 0.237259433812102 3752 6954252 SGTC_2183 6420625 130.508 µM -0.715340385954646 0.237135266188439 no 2583 0.237199369589996 3713 2897619 SGTC_1774 st048371 48.465 µM -0.716286873118327 0.236837144040636 no 2584 0.2369071152995 3687 4242727 SGTC_2753 fluvastatin 17.09 µM -0.716301351425568 0.236832585300685 no 2585 0.236902646256391 3716 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2805 7950783 58.44 µM -0.716874305416869 0.236652219784637 no 2586 0.236725828810481 3725 1178958 YDL195W SEC31 SGTC_1824 st053723 68.6 µM -0.717022162085872 0.236605686877891 no 2587 0.236680211035935 3681 675225 SGTC_2617 dihydrotanshinone i 20.83 µM -0.718523994809814 0.236133320977301 no 2588 0.236217129203493 3730 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3150 9097574 49.47 µM -0.72069751198845 0.235450613567052 no 2589 0.23554782176241 3688 17217476 SGTC_3350 9150499 3.57 µM -0.722114294039482 0.235006185713245 no 2590 0.235112105348048 3689 4910996 YPR165W RHO1 SGTC_1849 st056239 19.2 µM -0.722407685022634 0.234914210375604 no 2591 0.235021931709432 3699 5393181 SGTC_323 4013-0906 34.3 µM -0.722799271308304 0.234791482725704 no 2592 0.23490160754641 3736 2910086 SGTC_282 k297-0036 65.7 µM -0.723583434900429 0.234545823418453 no 2593 0.234660757084723 3720 5061378 SGTC_925 2064-1272 59.6 µM -0.724633400322534 0.234217117636575 no 2594 0.234338481363578 3713 6815817 SGTC_1016 4226-1401 38 µM -0.725319169373229 0.234002566179523 no 2595 0.234128124158774 3706 2901613 SGTC_202 3594-0513 34.79 µM -0.726070052432321 0.233767767903627 no 2596 0.233897913442418 3699 708429 SGTC_3198 9112019 49.47 µM -0.726919733774777 0.233502233339597 no 2597 0.233637563820942 3754 45595555 SGTC_1074 carmofur 3.8 µM -0.727579539916283 0.23329615226485 no 2598 0.233435504462484 3746 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_223 busulfan 5 mM -0.728450569534629 0.23302425317719 no 2599 0.233168908443991 3704 2478 A DNA alkylator. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.728864983012485 0.23289495239412 no 2600 0.233042128279263 3686 2724278 An inhibitor of dopamine biosynthesis. SGTC_796 1234-0020 70.7 µM -0.729048600300724 0.232837674870674 no 2601 0.232985967080759 3678 46495034 SGTC_1990 st072050 59.8 µM -0.731136996945998 0.232186772041058 no 2602 0.232347739116799 3724 17233948 SGTC_1892 st058411 7.36 µM -0.73316043900083 0.231557081081964 no 2603 0.231730290506514 3695 3934738 SGTC_1402 3909-7673 35.9 µM -0.735444554037351 0.230847414448443 no 2604 0.231034397985772 3740 5328014 SGTC_1980 st071811 45.7 µM -0.735996312050585 0.23067616745954 no 2605 0.230866471088149 3803 4974850 SGTC_800 3448-7362 155 µM -0.739421937123446 0.229614559169887 no 2606 0.22982541275289 3817 15991913 SGTC_2234 tolnaftate 200 µM -0.740139870694444 0.229392417486344 no 2607 0.229607564091164 3719 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_424 splitomicin 100 mM -0.742047305590373 0.22880280805859 no 2608 0.229029337292311 3799 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_521 r062-0005 13.8 µM -0.742191586401251 0.228758243883212 no 2609 0.22898563273834 3660 2832033 SGTC_546 peri-Naphthalide 147 µM -0.742324839592003 0.228717090150043 no 2610 0.228945272752387 3700 223824 A penicillin ester. SGTC_489 paxilline 115 µM -0.743310784802267 0.228412721376413 no 2611 0.228646771812074 3701 105008 A toxic potassium channel blocker. SGTC_3288 9119690 36.221 µM -0.74533637664585 0.227788120469113 no 2612 0.228034197782691 3745 17595618 YKL019W RAM2 SGTC_2181 6316240 54.2555 µM -0.745575791602244 0.227714359298949 no 2613 0.227961855603907 3749 12779990 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.745963620810352 0.227594901830153 no 2614 0.227844695630604 3786 6708784 An antioxidant flavonoid SGTC_3201 9113999 49.47 µM -0.746673041290673 0.227376480544473 no 2615 0.227630473312864 3784 16649224 SGTC_2853 9015042 58.44 µM -0.747313552509429 0.227179377002827 no 2616 0.227437156839712 3702 6457456 SGTC_1681 tripelennamine 100 µM -0.748214331220811 0.226902344768052 no 2617 0.227165444041478 3728 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3305 9127027 53.8275 µM -0.74975320932122 0.22642950778282 no 2618 0.226701677165688 3694 41905295 SGTC_2189 6047310 154.431 µM -0.752119848390751 0.225703419302112 no 2619 0.225989494349069 3701 711535 SGTC_2691 st077356 60.2 µM -0.752161928934485 0.225690520857017 no 2620 0.225976842681902 3811 2839272 SGTC_1607 st000305 50.6 µM -0.75332085352446 0.225335453518756 no 2621 0.225628565236862 3749 5457690 SGTC_195 4234-0266 16.654 µM -0.753464153867543 0.225291571636276 no 2622 0.225585522045446 3758 2303354 SGTC_2702 st077768 96.8 µM -0.753719812418045 0.22521329508971 no 2623 0.225508741308 3714 6484119 SGTC_199 4063-0024 41.6 µM -0.757937100077622 0.2239242872848 no 2624 0.224244319425098 3786 306215 SGTC_97 0535-0701 19.132 µM -0.758877049150833 0.223637565600003 no 2625 0.22396305464542 3695 2832013 YGL099W LSG1 SGTC_3085 9117376 49.47 µM -0.761255422615916 0.222913000730517 no 2626 0.223252260300158 3867 16480349 SGTC_1510 1123-0200 71.5 µM -0.761785981254 0.222751550140856 no 2627 0.223093874305533 3807 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_442 cape 100 µM -0.762033317627335 0.222676307718718 no 2628 0.223020059630959 3729 5281787 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.763001120261166 0.222382030888177 no 2629 0.222731363879144 3762 688803 SGTC_757 1066-0008 322 µM -0.764746564747748 0.22185186005333 no 2630 0.22221123620294 3827 6842497 SGTC_1675 st018485 24.5 µM -0.767269771603631 0.221086725024022 no 2631 0.221460568535581 3846 3323024 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.767628592553504 0.220978039244435 no 2632 0.221353935234241 3767 2333 A French combination drug. SGTC_3044 9093193 49.47 µM -0.768264795208571 0.22078541058667 no 2633 0.221164942692955 3755 25236277 SGTC_2829 7992743 58.44 µM -0.768329141880556 0.220765933136438 no 2634 0.221145832792177 3836 16462845 SGTC_2669 eugenol 100 µM -0.769910537267688 0.220287561170107 no 2635 0.220676481433727 3747 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2756 carbadox 75.1 µM -0.770137228762223 0.220219035749395 no 2636 0.220609247161968 3803 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1513 0337-0559 19 µM -0.771562477339338 0.219788484709449 no 2637 0.220186802609237 3770 775073 SGTC_3221 9128209 49.47 µM -0.774403724335487 0.218931620363644 no 2638 0.219346040954985 3832 16460723 SGTC_547 1120-0019 610 nM -0.775817541522364 0.218505957858828 no 2639 0.218928362563893 3717 3676939 SGTC_2950 9072895 21.46 µM -0.776035422696852 0.218440402076409 no 2640 0.218864035505586 3739 17332245 SGTC_395 anisomycin 6.25 µM -0.776131620877659 0.218411461707596 no 2641 0.218835637494878 3799 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.776418965013009 0.218325029926082 no 2642 0.218750825212173 3828 23665772 A membrane-active detergent. SGTC_2607 solasodine 47.35 µM -0.776926191678558 0.218172506600753 no 2643 0.218601158741231 3826 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2172 5754775 163.918 µM -0.777065547125467 0.218130613099982 no 2644 0.218560049702529 3778 2263357 SGTC_1805 st050013 60.3 µM -0.779370733488431 0.2174382932468 no 2645 0.217880679330129 3763 4037144 SGTC_2647 atorvastatin 60.16 µM -0.780086279580076 0.217223650562945 no 2646 0.217670045925795 3791 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1571 st070080 73.4 µM -0.780147212506876 0.217205378141884 no 2647 0.217652114692008 3867 4315245 SGTC_135 0933-0004 26.348 µM -0.780444602841091 0.217116210178501 no 2648 0.21756461142358 3793 21230617 YGL099W LSG1 SGTC_2178 5812956 200 µM -0.780464108720772 0.217110362376678 no 2649 0.217558872779793 3782 5403383 SGTC_1196 1588-0294 184 µM -0.780662534491562 0.217050880121788 no 2650 0.217500500740489 3822 6144269 SGTC_1135 dihydrocapsaicin 536.708 nM -0.782866711338735 0.216390765831935 no 2651 0.216852693728168 3739 107982 A Capsaicinoid. SGTC_2866 9034245 58.44 µM -0.783649296562212 0.216156674380573 no 2652 0.216622960735105 3786 6462273 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.786223637601016 0.215387657936488 no 2653 0.215868240142145 3794 16623 A steroid. SGTC_799 1310-0557 151 µM -0.787481750398936 0.215012408099286 no 2654 0.215499953719303 3881 5354492 SGTC_691 1548-0686 185 µM -0.789877963181731 0.214298754984954 no 2655 0.214799521093559 3832 46495133 SGTC_2762 leflunomide 42.06 µM -0.7910392377915 0.213953394126683 no 2656 0.21446054739176 3790 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2731 amoxapine 43.43 µM -0.791679122601497 0.213763232142225 no 2657 0.214273899304018 3869 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.794916081126339 0.212802777339859 no 2658 0.213331159610793 3815 16486 A toxic proline analog. SGTC_2364 9055074 200 µM -0.795150392558041 0.212733351486966 no 2659 0.213263012165064 3833 6470630 SGTC_2808 7946468 45.46 µM -0.795264333987892 0.21269959572425 no 2660 0.213229877877164 3844 2970879 SGTC_1103 duloxetine 36.1 µM -0.79542387890078 0.212652334939773 no 2661 0.213183487093542 3922 60835 A selective serotonin reuptake inhibitor. SGTC_1053 3366-3204 134 µM -0.798380276590167 0.211777693770575 no 2662 0.212324922701789 3844 3632071 YPR165W RHO1 SGTC_1519 esterone 74 µM -0.798437675339681 0.21176073338498 no 2663 0.212308273612161 3822 698 A steroid. SGTC_3121 9125696 49.47 µM -0.798670898462049 0.211691827968196 no 2664 0.212240632728137 3889 1235365 SGTC_3263 9137018 49.47 µM -0.799863101972168 0.211339798307541 no 2665 0.211895058957257 3835 43844957 SGTC_1486 3970-0793 4.53 µM -0.800134431401059 0.211259729035034 no 2666 0.211816457036226 3874 2844330 SGTC_2964 9083345 53.42 µM -0.800240094969943 0.211228552541088 no 2667 0.211785851778761 3829 17741579 SGTC_869 0564-0080 44.1 µM -0.800700613956192 0.211092705899084 no 2668 0.211652493523701 3846 6843321 SGTC_1994 st072947 40.9 µM -0.801182322560534 0.210950663425738 no 2669 0.211513051736034 3897 5286565 YDL195W SEC31 SGTC_1075 aripiprazole 15.2 µM -0.80210081364134 0.210679981289729 no 2670 0.211247322190248 3862 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2522 biochanin a 4.94 µM -0.804829389644933 0.209877064341636 no 2671 0.210459069734589 3813 5280373 A possible chelator. SGTC_2630 antimycin a 100 µM -0.805651971170135 0.209635362935105 no 2672 0.210221775046902 3836 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2400 5203494 178.7 µM -0.806164710060428 0.209484786304641 no 2673 0.210073941927491 3770 6777674 SGTC_1070 indatraline 8.81 µM -0.806715178450856 0.209323200454021 no 2674 0.209915298624399 3835 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3143 9086658 49.47 µM -0.806837665070858 0.20928725540881 no 2675 0.209880007935141 3929 25236626 SGTC_3185 9108267 49.47 µM -0.808026784044052 0.208938484254359 no 2676 0.20953758178963 3809 4910486 SGTC_2152 5568786 200 µM -0.808935115432186 0.208672299502626 no 2677 0.209276234532847 3815 5399883 SGTC_1591 genipin 88.4 µM -0.810175640972358 0.208309088986901 no 2678 0.208919617709627 3885 442424 A DNA cross-linking agent. SGTC_2861 9024595 19.48 µM -0.811032985086605 0.208058287333533 no 2679 0.208673364293713 3741 16482810 SGTC_362 0310-0100 9.03 µM -0.811418601313238 0.207945539906561 no 2680 0.2085626602393 3927 790235 SGTC_2390 9097792 176.6 µM -0.812176162933373 0.207724147240381 no 2681 0.208345277658879 3872 4497149 SGTC_1068 loratadine 26.9 µM -0.813389743538373 0.207369776201813 no 2682 0.207997318947261 3901 3957 A H1 histamine antagonist. SGTC_399 oxolinic acid 75 µM -0.818275789075393 0.205946649434519 no 2683 0.206599863737124 3821 4628 A DNA gyrase inhibitor. SGTC_1357 1503-1303 39.5 µM -0.818787540864769 0.20579793070551 no 2684 0.20645382029284 3834 292895 SGTC_1665 st014639 11.4 µM -0.821525747458964 0.205003271589177 no 2685 0.205673432191727 3906 981133 YIL048W NEO1 SGTC_2831 7999036 19.48 µM -0.821799663007394 0.204923878623913 no 2686 0.205595462786687 3935 2988270 SGTC_927 2425-1185 123 µM -0.823895617990095 0.204316982570796 no 2687 0.204999435257779 3837 730375 SGTC_2084 5306078 60.6385 µM -0.826656866010188 0.203519082653276 no 2688 0.204215788021493 3824 679340 SGTC_855 0428-0020 25 µM -0.826942079534806 0.203436772387611 no 2689 0.204134945677258 3876 6812414 SGTC_1779 st039427 55 µM -0.827176603913054 0.203369105471873 no 2690 0.204068485200959 3852 1124498 SGTC_1294 1000-1494 117 µM -0.828944027306006 0.202859585941811 no 2691 0.203568040283567 3857 712797 YDL207W GLE1 SGTC_1439 4092-1168 46 µM -0.829837487977532 0.20260230614453 no 2692 0.203315336178417 3881 2886240 SGTC_2998 9066762 71.4286 µM -0.829907835225086 0.202582057326633 no 2693 0.203295447297906 3880 4945196 SGTC_1478 0453-0656 35.7 µM -0.830172213418083 0.202505969275372 no 2694 0.203220711524476 3889 5258496 SGTC_606 k015-0008 38.6 µM -0.833608579466577 0.201518538149516 no 2695 0.202250794709389 3923 1970475 SGTC_821 1114-0266 29.2 µM -0.83595032621456 0.200847298984871 no 2696 0.201591424313921 3899 3123235 SGTC_2123 5259487 200 µM -0.836163488693492 0.200786264708463 no 2697 0.201531467737327 3888 2173474 SGTC_2133 5320837 200 µM -0.837025714713479 0.20053949930178 no 2698 0.201289056979386 3895 2841355 SGTC_3158 9100007 49.47 µM -0.838973040464506 0.199982853527624 no 2699 0.200742219173933 3909 19297233 SGTC_72 0744-0168 198.391 µM -0.839060254818659 0.199957944938008 no 2700 0.200717748976925 3802 677577 SGTC_1786 berberine 21.6 µM -0.841149725500623 0.19936174592063 no 2701 0.200132030495692 3830 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2581 avocatin a 64 µM -0.841356478527367 0.199302810306014 no 2702 0.200074129588722 3892 6710728 A skin care supplement. SGTC_2996 9066192 71.4286 µM -0.843094357842151 0.198807837075175 no 2703 0.19958783700495 3965 6472854 SGTC_2684 capsaicin 100 µM -0.844066952232441 0.198531151800573 no 2704 0.199315996796466 3917 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1299 1079-1439 3.74 µM -0.844886950031184 0.198298058031105 no 2705 0.199086980662733 3850 323161 SGTC_2349 9023730 187.07 µM -0.845141284122112 0.198225794225515 no 2706 0.199015980245158 3901 4126287 SGTC_516 3992-2719 87.3 µM -0.845324257394749 0.19817381596321 no 2707 0.198964910495484 3843 5350887 YDR037W KRS1 SGTC_3184 9108758 49.47 µM -0.845329812905459 0.198172237906281 no 2708 0.19896336001802 3908 902885 SGTC_2945 9067681 61.76 µM -0.845800875794434 0.198038458890572 no 2709 0.198831918411552 3983 16456930 SGTC_1165 k072-0275 30.3 µM -0.846008584049794 0.197979488329805 no 2710 0.198773977800598 3879 6153523 YGL055W OLE1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.851439807820352 0.196441273712798 no 2711 0.197262543265115 3964 688664 SGTC_1080 nisoldipine 24.4 µM -0.853089871076429 0.195975386169782 no 2712 0.196804733993139 3894 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1275 0867-0008 21.1 µM -0.853707262025485 0.195801241227453 no 2713 0.196633604702234 3872 3422836 SGTC_1038 k292-0204 154 µM -0.85495583688298 0.195449347955155 no 2714 0.196287798566418 3861 4454212 SGTC_3166 9102297 49.47 µM -0.855819703639425 0.195206104223724 no 2715 0.196048757376573 3938 25237072 SGTC_495 decylubiquinone 155 µM -0.85703999546925 0.194862813562501 no 2716 0.19571139059182 3959 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2064 5220758 200 µM -0.858657798031829 0.194408262232225 no 2717 0.195264670083628 3992 788518 SGTC_1789 tunicamycin 25 nM -0.859319851940047 0.194222432312877 no 2718 0.195082037289724 3847 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2528 xanthyletin 44.79 µM -0.860033072719309 0.194022361609422 no 2719 0.194885405936517 3968 65188 An natural product with antifungal activity of unknown mechanism. SGTC_31 0508-1974 57.237 µM -0.861295760467129 0.193668464053816 no 2720 0.194537585036624 3867 6810525 SGTC_2129 girgensonine 121.053 µM -0.861320729175365 0.193661469964635 no 2721 0.194530710949239 3951 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1935 st074532 41.6 µM -0.861541128512576 0.193599739665749 no 2722 0.194470039640463 3928 2829742 SGTC_1881 5652484 16 µM -0.861897350576672 0.193499992986983 no 2723 0.194372003542887 3872 2255129 SGTC_1609 st001574 46.4 µM -0.862562905302533 0.193313713274974 no 2724 0.194188916454503 3904 3960012 SGTC_1931 st074438 57.1 µM -0.863250919292489 0.19312126259948 no 2725 0.193999761515164 3899 2787313 SGTC_974 1326-0144 138 µM -0.863646010274413 0.193010800981699 no 2726 0.193891190344167 3957 5411856 SGTC_1773 st048542 73.5835 µM -0.864232307710523 0.192846951981372 no 2727 0.193730143825526 3861 3237138 SGTC_295 k015-0027 31 µM -0.865389727926695 0.192523744279173 no 2728 0.193412458528644 3945 3887424 SGTC_591 4299-0174 154 µM -0.866088890881329 0.192328664695089 no 2729 0.193220708416287 3905 5509088 SGTC_2973 9094665 17.96 µM -0.866347479939603 0.192256544129711 no 2730 0.193149818042843 3997 25237061 YIL048W NEO1 SGTC_171 k064-0041 9.68 µM -0.866537062720082 0.192203679946559 no 2731 0.193097855344216 3945 53325 SGTC_3239 9133757 49.47 µM -0.866862338832461 0.19211299909459 no 2732 0.193008720379529 3927 17036923 SGTC_3309 9129340 25.759 µM -0.870999164966481 0.190962014564468 no 2733 0.191877304515008 3969 17158987 SGTC_1316 1272-0050 65.9 µM -0.871991665779007 0.190686502583072 no 2734 0.191606462099639 3895 7340392 SGTC_1144 3486-0183 12.5 µM -0.872262747899381 0.190611294329981 no 2735 0.191532527542732 3921 6744069 SGTC_790 1575-0012 79.1 µM -0.872813520889125 0.190458545527569 no 2736 0.191382364329133 4017 378741 YLR208W SEC13 SGTC_3335 9143315 29.6265 µM -0.872985044552198 0.190410991311152 no 2737 0.191335614709392 3934 4899691 SGTC_300 r073-0011 5.04 µM -0.876882589572062 0.189332379492761 no 2738 0.190275206858518 3925 2735780 SGTC_141 0443-0274 32.331 µM -0.877544912470716 0.189149461948321 no 2739 0.190095367737444 3986 1627241 SGTC_6 0844-0013 19.835 µM -0.879631165879672 0.188574000902019 no 2740 0.189529574864069 4067 1584900 SGTC_934 2950-0684 338 µM -0.879713404083072 0.188551338889868 no 2741 0.189507293073958 4013 1121253 SGTC_1661 st013063 9.66 µM -0.880840372065216 0.18824095459199 no 2742 0.189202112435397 3982 721395 SGTC_2517 totarol 10 µM -0.883762614389277 0.187437593884174 no 2743 0.188412185902145 3964 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1615 st002656 86.5 µM -0.883932193702344 0.187391039571153 no 2744 0.188366408567549 3938 1584458 SGTC_1763 st044482 94.5 µM -0.884251198504208 0.187303483110687 no 2745 0.188280312945932 3979 88505 SGTC_1608 st001473 40.5 µM -0.884556712984237 0.187219653020875 no 2746 0.188197880966398 3923 7292267 SGTC_2932 9016711 44.54 µM -0.885845945341369 0.18686615626267 no 2747 0.18785027380226 3971 7117328 SGTC_3340 9146634 11.102 µM -0.886455226167046 0.186699240364956 no 2748 0.187686135509588 3983 4907387 SGTC_1471 k673-0312 37 µM -0.886472467120127 0.186694518452468 no 2749 0.187681492141714 3907 24099884 SGTC_584 0986-0246 15.4 µM -0.890162976615595 0.185685472401383 no 2750 0.186689190672257 4038 53315 YDR232W HEM1 SGTC_1726 st035556 14.5795 µM -0.891977427636532 0.185190614689565 no 2751 0.186202515638216 4079 5919439 SGTC_2628 lathosterol 100 µM -0.894606166701822 0.184475129558206 no 2752 0.185498827087635 4058 6710616 SGTC_646 4092-0839 27.3 µM -0.895008175152747 0.184365863449583 no 2753 0.185391358925288 4020 877796 SGTC_2571 chrysanthemic acid 100 µM -0.895627941795149 0.184197489457577 no 2754 0.185225753620585 3987 2743 An insecticide. SGTC_50 0929-0078 56.389 µM -0.896401420587679 0.183987490290267 no 2755 0.185019204437349 3841 1377751 SGTC_1331 1472-0049 76.2 µM -0.899120986794915 0.18325031340393 no 2756 0.184294110306911 3910 24051409 SGTC_814 3342-0569 96 µM -0.899962839962917 0.183022491058282 no 2757 0.184070013249855 4000 4346283 SGTC_860 0443-0016 25.1 µM -0.900715316422719 0.182819005484002 no 2758 0.183869851468178 3992 5337942 SGTC_1032 k061-1018 98.7 µM -0.901778603867214 0.182531710899786 no 2759 0.183587243923605 4086 4005393 SGTC_576 1073-0113 22.7 µM -0.902090165901268 0.18244758195064 no 2760 0.183504486219295 4113 5439563 SGTC_1303 1160-0052 261 µM -0.902825459662826 0.182249131701152 no 2761 0.183309268292931 3936 3562476 SGTC_1837 st055472 66.5 µM -0.904271847590386 0.181859156344581 no 2762 0.182925635430005 4077 676091 SGTC_2050 5263056 171 µM -0.90798177688417 0.180861273119318 no 2763 0.18194392482887 4006 763468 YGL055W OLE1 SGTC_2365 9042475 200 µM -0.908139173902644 0.180819013073944 no 2764 0.181902347878063 4062 6464479 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.914726998297523 0.1790557802034 no 2765 0.180167483604046 4038 94937 An inhibitor of serotonin biosynthesis. SGTC_835 0312-0010 67.2 µM -0.915409619366462 0.178873697071249 no 2766 0.179988315165573 3942 1626196 SGTC_858 0438-0351 2.77 µM -0.915576389991494 0.178829230202278 no 2767 0.17994455967467 3970 2799119 SGTC_2872 9044037 25.97 µM -0.919923389112492 0.177672623771426 no 2768 0.178806397695234 3988 6465195 SGTC_3299 9121982 43.1275 µM -0.921075158357727 0.177366965172213 no 2769 0.178505594409565 4071 17594604 YPL160W CDC60 SGTC_1022 4477-0945 21.3 µM -0.923692969440858 0.176673481470547 no 2770 0.177823096798603 3946 4648966 SGTC_568 1193-0097 7.48 µM -0.923834608481528 0.176636008860026 no 2771 0.17778621664543 3869 3646150 SGTC_1152 3909-8331 15.9 µM -0.926251284692657 0.175997417582431 no 2772 0.177157703078645 3979 16001939 SGTC_2043 5101342 149 µM -0.926540055916658 0.175921209519972 no 2773 0.177082695304796 4013 678451 SGTC_1051 3253-3903 78 µM -0.927128928502276 0.175765868087822 no 2774 0.176929798958929 3990 5509239 SGTC_2729 fluphenazine 10.66 µM -0.927535197926067 0.175658747061099 no 2775 0.176824362800855 3942 3372 An atypical antipsychotic. SGTC_1371 2421-0008 32.7 µM -0.928322388576005 0.175451306319098 no 2776 0.176620181973752 3978 2827552 SGTC_2434 5670830 169.91 µM -0.928738316063143 0.175341763695309 no 2777 0.176512359286467 4045 1549830 SGTC_2727 riluzole 51.77 µM -0.928903425290977 0.175298290982872 no 2778 0.17646956885116 4016 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_257 daunorubicin 18.5 µM -0.931271502621874 0.174675536165481 no 2779 0.175856569583005 4033 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2507 purpurin 79.67 µM -0.933596922534668 0.174065368042839 no 2780 0.175255926692146 4011 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_229 benomyl 22.8748 µM -0.935584507598885 0.173544919905239 no 2781 0.174743577100184 4027 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_405 ebelactone b 50 µM -0.935607242219797 0.173538972590465 no 2782 0.174737722190572 3985 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2827 7993847 71.43 µM -0.936927576591085 0.173193799237591 no 2783 0.174397906487127 4087 2985692 SGTC_1966 st070145 16.1 µM -0.939118976214874 0.172621870181855 no 2784 0.17383483121047 3966 3748532 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.940652352525907 0.17222239425869 no 2785 0.173441521941365 4000 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_678 1218-2179 85.9 µM -0.942632751096544 0.171707333559627 no 2786 0.172934390865569 4001 6820081 YOR116C RPO31 SGTC_990 3985-0011 41.3 µM -0.943565197254444 0.171465164668682 no 2787 0.172695941964622 4013 5399565 YGL099W LSG1 SGTC_453 enantio-paf c16 10 µM -0.946522870952767 0.170698461879388 no 2788 0.171940981305903 3881 13871343 A lipid and platelet activating factor SGTC_2233 sulbentine 40.3845 µM -0.947223381987076 0.170517193861144 no 2789 0.171762481551814 4014 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1871 st057448 67.3 µM -0.948930176562643 0.170076050716897 no 2790 0.171328062755191 4070 691747 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.949089932121355 0.170034797294241 no 2791 0.171287437240331 4028 4620898 SGTC_16 erodoxin 22.806 µM -0.949893264618601 0.169827451250854 no 2792 0.171083244773585 4047 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2943 9068529 45.32 µM -0.950993756540953 0.169543669469156 no 2793 0.170803772639217 4019 3270634 SGTC_3316 9136639 10.545 µM -0.953649079268541 0.16886019988473 no 2794 0.17013065179173 4055 4903665 SGTC_2092 5303694 80.6725 µM -0.953744267117821 0.168835731819501 no 2795 0.170106553400253 4029 1963699 SGTC_1270 0831-1170 17.3 µM -0.95436577559224 0.168676028877891 no 2796 0.169949261939888 4014 6764716 SGTC_2904 7225135 42.03 µM -0.954930403099802 0.168531026279467 no 2797 0.169806446778929 4139 4446116 SGTC_2150 5556613 200 µM -0.957786740481789 0.167798715811933 no 2798 0.16908515335227 4032 743190 SGTC_1318 1280-3875 124 µM -0.957923109337386 0.167763804755246 no 2799 0.169050766240852 4053 373245 SGTC_56 0957-0365 83.25 µM -0.960453930681946 0.16711675174237 no 2800 0.168413403268784 4031 6752360 SGTC_2264 7948757 110.76 µM -0.96137435072411 0.166881828246144 no 2801 0.168181988044513 4004 2971411 SGTC_961 1252-1571 372 µM -0.962184317718338 0.166675272544207 no 2802 0.167978512622783 4061 6813498 SGTC_2919 7978188 46.38 µM -0.963063617924626 0.166451222519184 no 2803 0.167757799144124 4048 2980291 SGTC_2776 terbinafine 19.92 µM -0.963627503753527 0.166307644008857 no 2804 0.167616356268317 4074 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2885 9057732 51.95 µM -0.964251447609285 0.166148866562781 no 2805 0.167459938223295 4127 6471414 SGTC_951 1171-0579 82.7 µM -0.964300084153044 0.166136493945821 no 2806 0.167447749359052 3995 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2323 6148992 148.28 µM -0.968677876637494 0.165025268550678 no 2807 0.166352967051174 4025 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2066 5222451 176 µM -0.969117286971823 0.16491399835053 no 2808 0.166243336741637 4018 2281147 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.971970988768446 0.1641925490671 no 2809 0.165532490754586 4064 115019 SGTC_1573 oleylamine 1.06 µM -0.972513684030527 0.164055581329666 no 2810 0.16539753029595 4052 5356789 An amine of the fatty acid oleic acid. SGTC_578 3460-0051 92 µM -0.972945367798331 0.163946684088799 no 2811 0.165290227639957 4144 2876744 SGTC_2173 5763948 167 µM -0.973543181080429 0.163795956217581 no 2812 0.165141704952354 4041 2867177 SGTC_2624 nerol 100 µM -0.973593161509697 0.16378335862636 no 2813 0.165129291565331 3962 637566 A natural product oil. SGTC_2725 haloperidol 53.21 µM -0.974655023971549 0.163515864296576 no 2814 0.164865704884033 3999 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2686 alizarin 95.37 µM -0.975075575183387 0.163410001497847 no 2815 0.164761386610301 4064 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3011 9081274 71.4286 µM -0.975454899972342 0.163314554570466 no 2816 0.164667331289744 4058 6625322 SGTC_1781 st038725 66.3 µM -0.977046454620908 0.162914477333098 no 2817 0.164273077296979 4044 4270275 YIL048W NEO1 SGTC_943 3253-1379 105 µM -0.977576270365157 0.162781436331676 no 2818 0.164141969218399 4092 668464 SGTC_2813 7971799 71.43 µM -0.981067882722024 0.161906432129085 no 2819 0.163279633651993 4113 2234054 SGTC_1375 2910-0797 186 µM -0.982003888261307 0.161672389281854 no 2820 0.163048966328905 4075 742508 SGTC_2773 thioridazine 9.09 µM -0.983349719785708 0.161336258457604 no 2821 0.162717673736996 4094 5452 An antipsychotic. SGTC_2332 7982454 138.89 µM -0.984505144054283 0.161048047074211 no 2822 0.162433601728523 4008 2981748 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.986629575371807 0.160519001987762 no 2823 0.161912132961808 4114 6708760 SGTC_731 3966-0296 387 µM -0.987601612969877 0.160277315414694 no 2824 0.161673898016354 4073 660956 SGTC_2730 imipramine 71.33 µM -0.990745389002588 0.159497279102224 no 2825 0.160904960844555 4046 3696 A tricyclic antidepressant. SGTC_481 bay k-8644 50 µM -0.99275289069585 0.15900047838196 no 2826 0.160415196387753 4040 2303 A calcium channel antagonist. SGTC_3255 9139072 49.47 µM -0.993313133383928 0.158862015089918 no 2827 0.160278689612829 4093 17646060 SGTC_1762 st045503 25.4615 µM -0.994866879443315 0.158478422295055 no 2828 0.159900506652024 4162 4645554 SGTC_2698 st077697 67.5 µM -0.995591558205575 0.158299719680424 no 2829 0.159724319051802 4060 3154499 SGTC_3014 9081533 49.47 µM -0.998202532437663 0.157656961620078 no 2830 0.159090579349958 4124 21367265 SGTC_1668 st014914 51.6 µM -1.00071544187868 0.157039966162568 no 2831 0.158482199868932 4115 2839556 SGTC_1119 parthenolide 318.541 nM -1.00080561733783 0.157017854912721 no 2832 0.158460396642364 4210 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3283 9109332 35.8195 µM -1.00289355587842 0.156506459795927 no 2833 0.15795611108769 3925 17027281 SGTC_665 3914-0008 307 µM -1.00292079868944 0.156499794518231 no 2834 0.157949538288919 4030 1069549 SGTC_2760 etidronate 98.04 µM -1.0033132518687 0.156403796921383 no 2835 0.157854872107349 4044 3305 A chelator and antioxidant. SGTC_1235 benzylparaben 21.5 µM -1.00477605566745 0.156046323613684 no 2836 0.157502348032519 4109 7180 SGTC_601 0986-0029 62.9 µM -1.00478906969147 0.156043145724388 no 2837 0.157499214079933 4040 24747981 SGTC_2283 7944793 200 µM -1.00846697215025 0.155146749450008 no 2838 0.156615167836653 4129 2970533 SGTC_1363 1636-0063 10.4 µM -1.00894474019714 0.155030555482695 no 2839 0.156500568378971 4103 6072185 SGTC_2900 5328528 85.29 µM -1.0105462986114 0.15464147313988 no 2840 0.156116814692609 4101 795359 SGTC_499 genistein 192 µM -1.01876545579244 0.15265487367776 no 2841 0.154157164573945 4167 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1220 1838-0075 193 µM -1.0228988186741 0.151662251309846 no 2842 0.153177844055906 4018 5529645 SGTC_2512 diallyl trisulfide 49.23 µM -1.02394792732373 0.151410993211235 no 2843 0.152929935501414 4140 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_832 4083-0019 164 µM -1.02408282983293 0.151378704596961 no 2844 0.152898076814719 4192 1990758 SGTC_2441 5730946 39.09 µM -1.02481464334967 0.151203626466692 no 2845 0.152725327830269 4168 1774275 SGTC_752 1896-0090 130 µM -1.024860747652 0.151192601044608 no 2846 0.152714448968845 4102 772567 SGTC_2695 st077686 51.995 µM -1.02498794615705 0.15116218545921 no 2847 0.152684437625956 4151 2876092 SGTC_1137 ixabepilone 100 µM -1.02538641831217 0.151066929529225 no 2848 0.152590447032337 4072 154225 A novel microtubule stabilizer. SGTC_1158 4092-0494 91.8 µM -1.02713792656869 0.150648700107158 no 2849 0.15217776103495 4214 1148199 SGTC_2589 lobaric acid 100 µM -1.02953016618257 0.150078722208022 no 2850 0.151615305935264 4121 73157 A novel microtubule depolymerizer. SGTC_1662 st014054 52 µM -1.03768443952382 0.148146689666327 no 2851 0.149708495810666 4165 2838777 SGTC_3079 9117512 49.47 µM -1.03819387278524 0.14802654195874 no 2852 0.149589902334573 4173 7185044 SGTC_3277 9138724 49.47 µM -1.03890669516088 0.147858535277035 no 2853 0.149424066161947 4087 15943418 SGTC_124 0136-0217 7.121 µM -1.03892596623245 0.147853995008632 no 2854 0.149419584504317 4177 3976905 SGTC_2240 6690706 185.951 µM -1.03920784437666 0.147787595128162 no 2855 0.149354041510922 3982 805876 SGTC_2974 9094440 9.66 µM -1.03922257546672 0.147784125586945 no 2856 0.149350616729774 4159 25236134 SGTC_3096 9117468 49.47 µM -1.03928761148596 0.147768808625025 no 2857 0.149335497353008 4019 41316311 SGTC_1617 st002906 78 µM -1.04280722943086 0.146941470939075 no 2858 0.14851879119656 4125 5150859 SGTC_2649 anisomycin 9.56 µM -1.0431056468742 0.146871466703341 no 2859 0.148449682835419 4153 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2789 5281112 71.43 µM -1.04379594794016 0.146709618212683 no 2860 0.148289903371303 4153 765948 SGTC_1455 4262-0120 131 µM -1.04432562452501 0.146585511026327 no 2861 0.148167380635863 4207 1529587 SGTC_3333 9141820 12.094 µM -1.04736693687605 0.145874272830274 no 2862 0.147465187367505 4127 1939433 SGTC_681 1642-0006 26.6 µM -1.04742878884903 0.145859832294671 no 2863 0.147450929849843 4163 4446530 SGTC_3118 9124250 49.47 µM -1.04755107859466 0.145831284223374 no 2864 0.147422743520667 4070 1504786 SGTC_1013 4112-3890 241 µM -1.04980395650496 0.145306030370903 no 2865 0.146904127912645 4090 705171 SGTC_614 0462-0418 107 µM -1.05027837042091 0.145195584176116 no 2866 0.146795073339684 3919 5188303 SGTC_158 k038-0087 26.446 µM -1.05241735480736 0.144698318382303 no 2867 0.146304054875495 4061 X158 SGTC_369 0957-0393 4.5 µM -1.05438803050802 0.144241196946711 no 2868 0.145852650017553 4188 6997992 SGTC_66 0109-0187 42.4 µM -1.05509110853022 0.144078345590352 no 2869 0.145691829079563 4042 759417 SGTC_2755 lomerizine 42.69 µM -1.0553732453908 0.144013030147897 no 2870 0.145627327077185 4118 3949 A calcium channel blocker. SGTC_10 0279-0212 42.575 µM -1.05555051377283 0.143972002256945 no 2871 0.145586809882499 4134 39851 YBR002C RER2 SGTC_504 lovastatin 124 µM -1.05564400593955 0.143950367132607 no 2872 0.145565443979498 4168 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2148 5546263 113.568 µM -1.05758777540014 0.143501054046737 no 2873 0.145121709083653 4131 792097 SGTC_2883 9059145 45.46 µM -1.05760451764327 0.14349718810134 no 2874 0.145117891026416 4151 16476510 SGTC_3066 9117245 49.47 µM -1.05806687453055 0.14339045321806 no 2875 0.14501247756303 4214 17176980 SGTC_878 0828-0289 13.7 µM -1.05849633487028 0.143291360519694 no 2876 0.144914610418889 4095 745350 YLR208W SEC13 SGTC_1836 st055642 81 µM -1.05956231834865 0.143045597824374 no 2877 0.144671882043562 4162 8571 SGTC_1737 st035557 69.7 µM -1.05972831105197 0.14300735381667 no 2878 0.144634109548196 4019 5716916 SGTC_2001 4023502 57.655 µM -1.06328169253309 0.142190326776208 no 2879 0.143827112461615 4196 108941 YCR052W RSC6 SGTC_296 1222-0039 74.9 µM -1.06475129616722 0.141853346803734 no 2880 0.143494245153868 4164 5984176 SGTC_2135 5326629 150.42 µM -1.06611813910844 0.141540415615099 no 2881 0.143185120425964 4119 5020077 SGTC_2927 9011802 47.9 µM -1.06622333540105 0.141516350900981 no 2882 0.143161347924675 4172 43912568 SGTC_3318 9139014 38.6185 µM -1.06724520343155 0.14128273253741 no 2883 0.142930562563589 4157 16643984 SGTC_794 k038-0031 316 µM -1.06791502434018 0.141129740732237 no 2884 0.142779422316304 4137 6624242 SGTC_597 k018-0003 82.8 µM -1.06980819648238 0.140697934540888 no 2885 0.142352826072847 4229 6786234 SGTC_89 0302-0250 142.109 µM -1.07093216534274 0.140441997498747 no 2886 0.142099965905389 4257 4203518 YLR208W SEC13 SGTC_2949 9072542 2.23 µM -1.0718451010374 0.140234347243429 no 2887 0.141894805915064 4225 16457352 SGTC_1806 st050005 60.3 µM -1.07338147616498 0.139885364597048 no 2888 0.141549996116764 4211 5194765 SGTC_2818 7996756 12.99 µM -1.07469925827426 0.139586505295482 no 2889 0.141254697972383 4183 2241621 SGTC_1093 fluphenazine 7.97 µM -1.07494445207983 0.13953094583319 no 2890 0.141199799287252 4173 6602611 An atypical antipsychotic. SGTC_899 1083-0020 478 µM -1.07698433195232 0.139069304223531 no 2891 0.140743632726895 4234 767123 SGTC_428 3448-4153 16.5 µM -1.08573703937823 0.137100303592768 no 2892 0.138797674312597 4151 3834874 SGTC_2028 5153890 36.43 µM -1.08703158751002 0.136810708134342 no 2893 0.138511425037803 4154 2830968 YPR165W RHO1 SGTC_3344 9148862 3.898 µM -1.08799129176435 0.136596288639134 no 2894 0.138299475953654 4225 4905352 SGTC_581 0958-0271 211 µM -1.08965294268172 0.136225582135784 no 2895 0.137933026131029 4179 4591145 SGTC_552 k242-0005 476 µM -1.09012551427794 0.136120279492279 no 2896 0.137828929307114 4260 4088318 SGTC_211 3455-0679 143.504 µM -1.09118191282466 0.135885084804144 no 2897 0.137596422496189 4231 748649 SGTC_3075 9116269 49.47 µM -1.09131104760834 0.135856353564427 no 2898 0.137568019100053 4219 17015205 YNL244C SUI1 SGTC_729 4092-0585 94.1 µM -1.09274755706923 0.135537024630292 no 2899 0.137252326501973 4186 2169061 SGTC_1666 st014829 29 µM -1.09286360971444 0.135511249173185 no 2900 0.137226843965547 4164 3858230 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.09387191007863 0.135287445594703 no 2901 0.137005580016049 4229 91467 include heat shock SGTC_744 1594-0068 283 µM -1.09504426323888 0.135027547386273 no 2902 0.136748622572362 4158 668392 SGTC_3022 9087993 49.47 µM -1.09560687835711 0.134902943281828 no 2903 0.136625425143141 4251 17173644 SGTC_1442 4112-3290 3 µM -1.0956507032504 0.134893240560111 no 2904 0.136615831869033 4171 704353 SGTC_793 0488-0545 106 µM -1.09632952892641 0.134743011389667 no 2905 0.136467295674673 4223 292548 SGTC_1134 3477-0009 42.5 µM -1.09668003341692 0.134665487099117 no 2906 0.136390643834049 4266 3973534 SGTC_2072 5231554 129 µM -1.09809068520913 0.134353789857679 no 2907 0.136082446180069 4220 789545 SGTC_3098 9119039 49.47 µM -1.09820157907188 0.134329307799969 no 2908 0.136058238436708 4187 17161528 SGTC_2427 5545055 42.75 µM -1.09861501456286 0.134238060575924 no 2909 0.1359680128936 4140 5372858 SGTC_2008 4012253 172 µM -1.1006199869237 0.133796157306858 no 2910 0.135531041499867 4192 603940 SGTC_1732 st034308 51.822 µM -1.10144767952953 0.133614022749968 no 2911 0.13535093189917 4061 830119 SGTC_1775 st081588 35.1725 µM -1.10260197340565 0.133360304050416 no 2912 0.135100026444649 4192 1426443 YGL099W LSG1 SGTC_2728 chlorpromazine 9.18 µM -1.10263885665961 0.133352202422578 no 2913 0.135092014502454 4255 2726 A thorazine and dopamine antagonist. SGTC_3052 9092717 49.47 µM -1.10428563894757 0.13299082183539 no 2914 0.134734625239696 4202 25237534 SGTC_2713 st079149 53.4 µM -1.106822031684 0.132435539242368 no 2915 0.134185440408842 4203 3103253 SGTC_1082 camptothecin 424.86 nM -1.10751679146296 0.132283717344759 no 2916 0.134035278281041 4085 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3274 9138298 49.47 µM -1.10949577981747 0.131851918028654 no 2917 0.133608181999066 4180 17015756 SGTC_17 0960-0276 49.807 µM -1.11129825065768 0.131459480386641 no 2918 0.133219996069708 4194 6821114 SGTC_1136 pergolide 1.05886 µM -1.11591596711142 0.130457783312843 no 2919 0.132229053211968 4175 47811 A dopamine receptor agonist. SGTC_1182 1222-0449 220 µM -1.11655951583831 0.130318601891041 no 2920 0.13209135480055 4204 658318 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.1168899133693 0.13024718615346 no 2921 0.132020698944587 4182 689007 SGTC_1382 3002-2117 298 µM -1.11813229715318 0.129978886096884 no 2922 0.131755247174539 4285 1497314 SGTC_1973 st070275 50.2 µM -1.11813978193076 0.129977270875538 no 2923 0.131753649069357 4158 17118334 SGTC_1246 0422-0085 105 µM -1.11826973662134 0.129949228758015 no 2924 0.131725904048907 4235 264295 SGTC_201 4262-0159 12.803 µM -1.11915278334018 0.12975879249668 no 2925 0.131537482423181 4246 1341029 SGTC_476 mead acid 10 µM -1.1237193930506 0.128777050128635 no 2926 0.130566043312199 4257 5312531 An omega 9 fatty acid. SGTC_2975 9084847 53.72 µM -1.12471880020224 0.128562883894505 no 2927 0.130354106230966 4273 27211724 SGTC_7 0192-1582 4.227 µM -1.12533469776965 0.128431024359383 no 2928 0.130223615846597 4260 252616 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.12733434254406 0.128003561176987 no 2929 0.129800573782305 4269 5357218 A potent inhibitor of glutathione S-transferases. SGTC_954 1189-0853 2.85 µM -1.12787749648338 0.127887622296123 no 2930 0.129685829422826 4153 2828194 SGTC_2783 7738165 71.43 µM -1.12801087642258 0.127859162854795 no 2931 0.12965766289928 4207 17201110 SGTC_2259 7964009 200 µM -1.12952227642549 0.127536981052026 no 2932 0.129338788862628 4250 313134 SGTC_2658 polymyxin b sulfate 77.05 µM -1.13125231035128 0.127168886931555 no 2933 0.128974455207595 4250 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_997 3996-0078 137 µM -1.13272397448837 0.126856347739532 no 2934 0.128665093236002 4269 735687 SGTC_1391 3442-0225 151 µM -1.13286572009216 0.12682627330193 no 2935 0.128635323767769 4197 5227075 SGTC_3233 9132340 49.47 µM -1.13319628822415 0.126756155313257 no 2936 0.128565916288917 4226 17682950 SGTC_62 0180-0423 3.232 µM -1.13578826791183 0.1262072967938 no 2937 0.128022594148991 4193 30102 YGL099W LSG1 SGTC_791 1348-1292 225 µM -1.13671121173345 0.126012261524967 no 2938 0.12782951540432 4199 5437054 SGTC_355 1311-2252 105 µM -1.13708387394379 0.125933570627205 no 2939 0.127751612295175 4212 5338538 SGTC_577 r071-0003 38.6 µM -1.14078106814461 0.125154731791547 no 2940 0.126980520415383 4226 4568517 YMR134W ERG29 SGTC_903 1134-0042 114 µM -1.14111269911756 0.125085036244743 no 2941 0.126911513660544 4241 701009 SGTC_1351 1496-0003 46.5 µM -1.14352847538096 0.12457815474555 no 2942 0.12640961946709 4257 3891978 SGTC_463 ikarugamyin 104 µM -1.1440966068385 0.124459157464231 no 2943 0.126291787366177 4373 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_9 0092-0002 10.449 µM -1.14422880811229 0.124431478810065 no 2944 0.126264379422704 4223 759368 SGTC_1669 st015249 58.4 µM -1.14667682511269 0.123919721201081 no 2945 0.125757605974809 4323 722793 SGTC_1764 st044502 93.5 µM -1.14792155830766 0.123660075599584 no 2946 0.125500473799303 4281 8407 SGTC_3043 9092303 49.47 µM -1.14853713386131 0.123531810256074 no 2947 0.125373446267861 4234 25236084 SGTC_1147 3809-1045 12.3 µM -1.15233368476181 0.122742795623291 no 2948 0.124591990052904 4250 325925 SGTC_769 0302-0231 76 µM -1.15261481156469 0.122684511584888 no 2949 0.124534260521911 4150 571869 YER009W NTF2 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.15335481862699 0.122531183953852 no 2950 0.124382389106409 4244 3256 An antibiotic and ribosome inhibitor. SGTC_798 1287-0182 476 µM -1.15501480980488 0.122187727113763 no 2951 0.124042180907798 4292 1649755 SGTC_2874 9043904 71.43 µM -1.15506162820868 0.122178050064707 no 2952 0.124032595123559 4182 4463428 SGTC_956 1185-0240 191 µM -1.15699799555413 0.121778287229265 no 2953 0.123636589643078 4226 1416193 SGTC_1356 1502-0781 85.8 µM -1.15832749381758 0.121504345113147 no 2954 0.123365207789973 4242 567702 SGTC_3267 9137951 49.47 µM -1.15848477516394 0.121471966087069 no 2955 0.123333130596383 4280 16643986 SGTC_782 0083-0095 30.5 µM -1.15956758593985 0.121249215795028 no 2956 0.12311245226005 4223 3591729 An indicator and reagent. SGTC_562 3772-2733 112 µM -1.16143425819153 0.120865888309234 no 2957 0.122732671969743 4234 2876874 YIL048W NEO1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.16880962191858 0.119359677081994 no 2958 0.121240171427767 4265 521171 SGTC_2424 5537928 59.2 µM -1.16959577178083 0.119199912640417 no 2959 0.121081839847742 4269 5382802 SGTC_2342 7990637 118.86 µM -1.17015367162489 0.119086625666282 no 2960 0.120969566388627 4287 2033102 YER133W GLC7 SGTC_2343 7990716 14.84 µM -1.17114707791096 0.118885093108788 no 2961 0.120769831673333 4252 6456862 SGTC_1041 0206-0046 107 µM -1.17204448929142 0.11870324225013 no 2962 0.120589597401601 4257 50494 SGTC_1999 st074831 12.5 µM -1.17380629528615 0.118346802850177 no 2963 0.120236310943905 4229 17112523 SGTC_690 glyoxal 20.3 µM -1.1751030975589 0.118084924470878 no 2964 0.119976735782654 4067 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2348 9022543 33.42 µM -1.17528358859716 0.118048508331499 no 2965 0.119940639030346 4290 3162678 YDL140C RPO21 SGTC_677 0929-0063 136 µM -1.17605826335912 0.117892299017543 no 2966 0.119785797270296 4265 1539583 SGTC_695 3505-6186 243 µM -1.17781288119372 0.117539029960528 no 2967 0.119435606102287 4254 1819379 SGTC_44 0929-0055 61.211 µM -1.18058958543682 0.116981509928251 no 2968 0.118882901438355 4152 1379590 SGTC_1449 4112-4002 201 µM -1.18132201960193 0.11683476114743 no 2969 0.118737411543689 4319 2059539 SGTC_2176 5809774 33.9695 µM -1.18221634203433 0.116655753821737 no 2970 0.118559934964063 4200 2870539 SGTC_1050 3232-1156 69.3 µM -1.18381116504605 0.116337017297622 no 2971 0.118243910767131 4254 700529 SGTC_574 1315-0397 40 µM -1.18483791041003 0.116132142284729 no 2972 0.118040770153602 4253 6794277 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.1878641232322 0.115529786983664 no 2973 0.117443473153217 4238 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2694 st077685 81.9 µM -1.18796559921528 0.115509627141683 no 2974 0.117423481541752 4201 2838096 SGTC_510 ag-490 170 µM -1.18844793383361 0.115413837760945 no 2975 0.117328490564304 4404 5328779 SGTC_2931 9014674 55.67 µM -1.19243889890207 0.11462341646861 no 2976 0.116544597720421 4241 2996810 SGTC_1177 0983-0204 23.6 µM -1.19355526945789 0.114403007431483 no 2977 0.116325990065199 4302 766818 SGTC_3152 9099253 49.47 µM -1.19368782727175 0.114376856122217 no 2978 0.116300051933613 4180 25236131 SGTC_1353 1498-1206 8.11 µM -1.19385887863518 0.114343117007076 no 2979 0.116266587675724 4308 6756808 SGTC_1328 1441-0025 69.2 µM -1.19470410757607 0.114176503405648 no 2980 0.116101328523102 4266 4562601 SGTC_2314 7727897 200 µM -1.19482813713877 0.114152068949822 no 2981 0.116077092299196 4270 900724 SGTC_1485 3909-9022 254 µM -1.1982541058866 0.113478607407489 no 2982 0.115409053732148 4346 714516 SGTC_1335 1486-0900 202 µM -1.20025631973968 0.113086335458897 no 2983 0.115019904157198 4271 X1335 SGTC_2534 helenine 20.12 µM -1.20223850754657 0.112698941118775 no 2984 0.114635566942086 4314 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1168 k815-0004 80.5 µM -1.20389555011799 0.112375820412919 no 2985 0.114314975967224 4261 642433 SGTC_3234 9132280 49.47 µM -1.20409286509687 0.112337388448902 no 2986 0.114276843664211 4313 17612295 SGTC_1291 0993-0025 5.79 µM -1.20445473792109 0.112266929189948 no 2987 0.114206933111219 4290 4353356 SGTC_947 3447-0010 211 µM -1.20595799172273 0.111974572893882 no 2988 0.113916844173614 4258 748350 SGTC_433 pimozide 108 µM -1.20615730993091 0.111935849936244 no 2989 0.11387842039423 4201 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2560 caryophyllene 100 µM -1.20697799111105 0.111776511283203 no 2990 0.113720310008201 4324 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2865 9030313 51.95 µM -1.20838296834894 0.111504105856976 no 2991 0.11344999396231 4267 42562754 SGTC_2058 5236698 133 µM -1.2099469207498 0.111201436487137 no 2992 0.113149630564166 4257 766665 SGTC_411 enrofloxacin 100 µM -1.21258985414203 0.110691291347911 no 2993 0.112643334926791 4360 71188 A bacterial gyrase inhibitor. SGTC_891 0929-0073 133 µM -1.21315091746541 0.110583209758818 no 2994 0.112536062894967 4327 5603632 SGTC_1965 Pectolinarigenin 58.4 µM -1.21481642142005 0.110262817582361 no 2995 0.1122180581262 4267 5320438 An anti-inflammatory. SGTC_2774 tamoxifen 10.92 µM -1.22538177756841 0.108245865364176 no 2996 0.110215704715943 4285 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_268 camptothecin 39.6153 µM -1.22574568255305 0.108176871224957 no 2997 0.11014719668053 4281 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_289 k017-0060 526 µM -1.22646138415731 0.108041270978714 no 2998 0.110012549232486 4292 5512909 SGTC_1231 0242-0792 125 µM -1.22995703297193 0.107380727178936 no 2999 0.109356597587747 4304 3707635 SGTC_2476 5806916 10.51 µM -1.23130893740996 0.10712605118987 no 3000 0.109103670234538 4200 2870194 SGTC_2982 9019404 25.97 µM -1.23156073688626 0.107078664577721 no 3001 0.109056607634515 4255 22333232 SGTC_1969 st069479 40.1 µM -1.23212248859697 0.106973001966568 no 3002 0.10895166597726 4312 3895485 SGTC_1437 4092-1038 11.6 µM -1.23388430690004 0.106642100892176 no 3003 0.108623009019202 4360 3977136 SGTC_756 0508-1999 28.3 µM -1.23394475291112 0.106630761170341 no 3004 0.108611745833315 4330 6753853 SGTC_2423 st077119 87.2 µM -1.23548115394191 0.106342823212691 no 3005 0.108325743077329 4237 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3321 9137793 26.8275 µM -1.240057536225 0.105488488399644 no 3006 0.107477056861151 4283 4904192 SGTC_174 3553-0389 74.3 µM -1.24316162834692 0.104911838132137 no 3007 0.106904139739939 4382 738071 SGTC_2514 salinomycin 42.74 µM -1.24342635708203 0.104862765033833 no 3008 0.106855381356393 4370 23682228 A polyether potassium ionophore. SGTC_1166 k206-0078 225 µM -1.2434708430156 0.104854520251767 no 3009 0.106847189403679 4341 5404595 SGTC_680 0417-1641 114 µM -1.24447783027049 0.10466801623025 no 3010 0.106661876892237 4329 2835990 SGTC_2419 paclitaxel 166.5 µM -1.24609758316753 0.104368526202998 no 3011 0.106364286007082 4258 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2459 5811157 9.22 µM -1.24771454186872 0.104070172698558 no 3012 0.106067806979777 4277 2870684 YBR192W RIM2 SGTC_709 3807-1509 243 µM -1.24901276902588 0.103831077949379 no 3013 0.105830201776787 4386 1886677 YPL242C IQG1 SGTC_1986 st071812 45 µM -1.25098289896306 0.103469000257317 no 3014 0.105470358338652 4277 11838594 SGTC_1236 0330-0013 258 µM -1.25668853165103 0.102425570231483 no 3015 0.104433221247683 4343 4617066 SGTC_871 0574-0004 149 µM -1.25768244857468 0.10224459078647 no 3016 0.104253311119604 4293 9551173 SGTC_2322 7413319 38.22 µM -1.25963441504011 0.101889840066493 no 3017 0.103900637294067 4311 1840400 SGTC_227 fluconazole 33.516 µM -1.26053872527356 0.101725794561136 no 3018 0.103737543593656 4333 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3091 9116372 49.47 µM -1.26291373653419 0.101295873825559 no 3019 0.103310091370761 4393 17169793 SGTC_1102 cgs 12066b 26.1 µM -1.26420593278134 0.101062519335753 no 3020 0.103078060982422 4339 6438352 A 5-HT1B full agonist. SGTC_2800 7887935 81.82 µM -1.26431981800814 0.101041971891097 no 3021 0.103057629595013 4334 2961002 SGTC_1955 wogonin 32.4 µM -1.26465157070534 0.100982133632508 no 3022 0.102998128825985 4371 5281703 A flavanone. SGTC_1697 st025554 27.742 µM -1.26592230539055 0.100753170105009 no 3023 0.102770449882515 4349 1269519 SGTC_1468 k284-1086 134 µM -1.26689559634667 0.100578056797214 no 3024 0.102596311768577 4343 15996457 SGTC_595 3909-8003 73.7 µM -1.27191847260614 0.0996778758490349 no 3025 0.10170104386367 4406 699517 SGTC_853 0419-0306 21 µM -1.27325992794765 0.0994384643168081 no 3026 0.101462910645744 4364 762713 SGTC_3356 9151811 4.48 µM -1.27360811485643 0.0993763916446702 no 3027 0.101401167448936 4343 1859254 YPR165W RHO1 SGTC_93 0109-0045 59.227 µM -1.27728748461182 0.0987221861675705 no 3028 0.10075038524518 4467 88733 SGTC_1221 2958-7315 257 µM -1.27746709462403 0.0986903317259577 no 3029 0.100718695187331 4366 4562705 SGTC_231 b-estradiol 524 µM -1.27868499133754 0.0984745320682419 no 3030 0.100504003504681 4312 450 A steroid. SGTC_707 0865-0008 204 µM -1.27904347541667 0.0984110779795252 no 3031 0.100440873330222 4389 723043 SGTC_3349 9149703 23.001 µM -1.28178971499698 0.0979259681349854 no 3032 0.0999582115460109 4366 4910494 SGTC_2168 5727979 200 µM -1.28412274414908 0.0975152286695871 no 3033 0.0995495055598559 4274 695210 SGTC_2319 6033012 152.6 µM -1.28647609763641 0.0971021925311847 no 3034 0.0991384777309732 4307 847246 SGTC_2305 7443522 69.23 µM -1.28965653357414 0.096546037664 no 3035 0.0985849688032461 4256 5415886 SGTC_1961 st076550 68.7 µM -1.29433539383566 0.0957321160898858 no 3036 0.0977747979806451 4382 1579337 SGTC_3020 9089140 49.47 µM -1.29682961559902 0.0953002964351944 no 3037 0.0973449091377167 4380 17217859 SGTC_795 0685-0265 78 µM -1.2981638208046 0.0950698976981521 no 3038 0.0971155237069437 4368 302754 SGTC_641 4092-0595 30 µM -1.29886657017565 0.0949487077092249 no 3039 0.0969948619855661 4410 786260 SGTC_1596 piperlongumine 63 µM -1.30063712402738 0.0946438781886509 no 3040 0.0966913467490219 4398 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_998 3996-0085 177 µM -1.30187634238084 0.0944309562062813 no 3041 0.0964793304682063 4380 715391 SGTC_2411 st077133 39.94 µM -1.30393710204145 0.094077659747203 no 3042 0.0961275143710087 4362 1403142 YNL221C POP1 SGTC_1380 2291-0730 164 µM -1.30579461450609 0.0937600445341514 no 3043 0.0958112059982891 4381 2999191 SGTC_2245 6637752 200 µM -1.3089645198391 0.0932198531393 no 3044 0.0952731847252036 4405 681890 SGTC_332 4112-0506 40.9 µM -1.31263790018357 0.0925967440143547 no 3045 0.094652496094463 4346 2790355 SGTC_95 0471-0001 561.058 µM -1.31333333788241 0.0924791257881717 no 3046 0.0945353247561809 4368 4015405 SGTC_2791 5663188 71.43 µM -1.3137624985416 0.0924065977325457 no 3047 0.094463070679401 4387 54690634 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.3144844657313 0.0922846804152774 no 3048 0.0943416111745701 4403 688664 SGTC_580 1123-0028 41 µM -1.31593109504478 0.0920407490293643 no 3049 0.0940985854511217 4431 1677248 YPR107C YTH1 SGTC_2440 5628896 157.78 µM -1.32099038335183 0.091191403597392 no 3050 0.0932522853759918 4356 5522048 SGTC_1670 st016595 4.04 µM -1.32313653384448 0.0908328720439514 no 3051 0.0928949885921103 4395 597879 SGTC_1787 fluconazole 80 µM -1.32596986593707 0.0903611446278318 no 3052 0.0924248395076523 4095 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1017 4239-0030 168 µM -1.32707367273483 0.0901778627769677 no 3053 0.0922421566351188 4396 1149593 SGTC_91 0417-1751 58.384 µM -1.32829345510424 0.0899756450989829 no 3054 0.0920405905230421 4487 6795624 SGTC_2383 9036125 200 µM -1.3299356592332 0.0897039300717678 no 3055 0.0917697355834113 4326 79580 SGTC_341 1486-1430 230 µM -1.33013250947786 0.0896714007069146 no 3056 0.09173730800016 4349 2054753 YPL210C SRP72 SGTC_2377 9073351 62.6 µM -1.33171647025308 0.0894099714513037 no 3057 0.0914766874920019 4378 7337946 YHR072W ERG7 SGTC_728 3030-5151 22.5 µM -1.33176194673743 0.0894024740382299 no 3058 0.0914692130297896 4468 3125388 SGTC_2030 5175110 200 µM -1.33703161001586 0.088536862247418 no 3059 0.0906061594847499 4392 2831986 SGTC_688 0527-0193 473 µM -1.33904743888044 0.0882073919471564 no 3060 0.0902776149321406 4436 4007154 SGTC_2417 cerulenin 830 nM -1.34022729652288 0.0880149785826259 no 3061 0.0900857298921625 4402 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2070 5230947 200 µM -1.34267658314652 0.0876165438760872 no 3062 0.0896883601847338 4495 2835538 SGTC_286 k060-0067 22.9 µM -1.35039039780641 0.0863705025948047 no 3063 0.0884453946366778 4429 5985051 SGTC_1258 0671-0043 57.1 µM -1.35039870779211 0.0863691674346325 no 3064 0.0884440625633383 4409 4298767 SGTC_2467 5474540 200 µM -1.35185789904235 0.0861349593153696 no 3065 0.0882103889523339 4388 5413519 SGTC_2778 tioconazole 65.09 nM -1.35549737761837 0.0855528739877079 no 3066 0.0876295717659264 4296 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2267 7931562 200 µM -1.35688698194416 0.0853314043454514 no 3067 0.0874085619209426 4355 934880 SGTC_2809 7964133 12.99 µM -1.36363701072971 0.0842617183243338 no 3068 0.0863409188289805 4392 1253665 SGTC_1020 4335-0961 93.3 µM -1.36440230427472 0.0841410792622749 no 3069 0.086220491540709 4369 669075 SGTC_801 0866-0028 10.1 µM -1.36601570465321 0.0838871715261046 no 3070 0.0859670170943473 4437 6849771 SGTC_2250 alverine citrate 130 µM -1.3711268637009 0.083086605280331 no 3071 0.0851677060084139 4283 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1406 3909-7906 11.9 µM -1.37346076405729 0.0827229605896953 no 3072 0.0848045753786389 4441 X1406 SGTC_1865 st057639 52.2 µM -1.37355762850436 0.0827078940803964 no 3073 0.0847895294074657 4408 688818 SGTC_2478 5763493 32.33 µM -1.37485396168487 0.0825064582669076 no 3074 0.0845883623543385 4349 1365576 YLR208W SEC13 SGTC_2033 5192550 145 µM -1.37607607965658 0.0823168931001795 no 3075 0.084399040180808 4426 182073 SGTC_2735 sertaconazole 140 nM -1.3780694235798 0.0820084055691978 no 3076 0.0840909274255496 4567 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_642 0335-0876 158 µM -1.37990463319829 0.0817251616001278 no 3077 0.0838080049368639 4461 6812350 SGTC_2378 9074213 121.43 µM -1.38043551564181 0.0816433635425992 no 3078 0.0837262956741595 4388 657714 SGTC_1985 st071382 65.5 µM -1.38080619135814 0.0815862866500498 no 3079 0.0836692796643741 4415 6123237 SGTC_652 0437-0092 114 µM -1.38146118290274 0.0814855041789495 no 3080 0.0835686025328644 4373 3091274 SGTC_2301 7769476 200 µM -1.38331185967179 0.0812012510157132 no 3081 0.0832846315607799 4404 977820 SGTC_200 k038-0079 37.545 µM -1.38564794586696 0.0808435108467322 no 3082 0.082927215115058 4424 3436683 SGTC_2145 5634607 200 µM -1.38583760980446 0.080814518674332 no 3083 0.0828982476385439 4411 308662 SGTC_1064 honokiol 6.76 µM -1.3868159281029 0.080665096869433 no 3084 0.0827489494421565 4451 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2202 7226349 200 µM -1.39012131233447 0.0801617977567114 no 3085 0.0822460212817215 4413 844334 SGTC_1705 st027868 56.3335 µM -1.39119838131764 0.0799983100937093 no 3086 0.0820826389849797 4357 292948 SGTC_1628 st004252 77.7 µM -1.39256098465788 0.0797918427086095 no 3087 0.0818762940143162 4434 692968 SGTC_1162 k048-0130 20.1 µM -1.39361037716478 0.0796331092654475 no 3088 0.0817176465771891 4401 6797406 SGTC_2137 5261020 140 µM -1.39487390147109 0.0794423029151138 no 3089 0.0815269342557819 4410 763655 SGTC_1232 0279-0259 161 µM -1.39580932102682 0.0793012671129975 no 3090 0.0813859613736428 4421 1560000 SGTC_2192 5915882 198.485 µM -1.39717252879565 0.0790960719962845 no 3091 0.0811808477794443 4398 2876149 SGTC_2775 cyproheptadine 69.59 µM -1.39728935893526 0.0790785050115772 no 3092 0.0811632872209288 4435 2913 A selective serotonin reuptake inhibitor. SGTC_675 1309-0189 238 µM -1.39855932137619 0.0788877396376572 no 3093 0.0809725860018066 4443 4246530 SGTC_2405 ticlatone 3.52 µM -1.40060011372768 0.0785819158244621 no 3094 0.0806668434666804 4236 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2636 apigenin dimethyl ether 100 µM -1.40245928225366 0.0783040923214781 no 3095 0.080389070671442 4402 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1401 3807-4679 7.6 µM -1.40349567612106 0.0781495432373887 no 3096 0.0802345402255005 4366 3291456 SGTC_540 1187-0821 17.3 µM -1.40497728995596 0.0779290040505057 no 3097 0.0800140157459268 4361 847520 SGTC_1629 st005085 44.9 µM -1.40705911136094 0.0776199219926091 no 3098 0.0797049306847516 4394 24207091 SGTC_3134 9127454 49.47 µM -1.40911313897899 0.0773158794485521 no 3099 0.0794008581701051 4488 24262820 SGTC_2479 5617353 43.85 µM -1.41690817700372 0.0761702649839735 no 3100 0.0782548877451801 4455 2731746 SGTC_1222 0366-0074 1.18 µM -1.41795841902058 0.0760169067676867 no 3101 0.0781014524658844 4468 286520 SGTC_1746 st038117 42 µM -1.42078634692059 0.0756051364192848 no 3102 0.0776894405150706 4480 2898218 SGTC_264 promethazine 12.5 mM -1.42364289841448 0.0751909257460643 no 3103 0.0772749355292759 4321 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3128 9127691 49.47 µM -1.42490530186017 0.0750084247379242 no 3104 0.077092288432427 4467 41316314 SGTC_764 1951-2361 146 µM -1.42862306988867 0.0744729231641063 no 3105 0.0765562998726988 4443 5438930 SGTC_3251 9135047 49.47 µM -1.43811504303104 0.0731189548193121 no 3106 0.0752007075346485 4509 17682963 SGTC_3097 9117246 49.47 µM -1.44672859204685 0.0719066640827043 no 3107 0.0739864766156679 4487 16423892 SGTC_2396 5342950 42.78 µM -1.44725824775747 0.07183262516961 no 3108 0.0739123040984384 4454 1886677 SGTC_1724 st037281 8.293 µM -1.44780720507839 0.0717559498608048 no 3109 0.0738354885800307 4416 574124 YDL195W SEC31 SGTC_2561 acetosyringone 100 µM -1.45508750041735 0.070745006518729 no 3110 0.0728225195706419 4413 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1539 benzyladenosine 56 µM -1.45529541498517 0.0707162970280564 no 3111 0.072793747715906 4484 92208 A nucleotide analog. SGTC_2680 butyl paraben 22.24 µM -1.45618848599575 0.070593080812963 no 3112 0.0726702607899671 4553 7184 An antifungal and steroid mimetic. SGTC_1903 st060211 78.3 µM -1.45688657353729 0.0704968812510222 no 3113 0.0725738464240703 4487 688960 SGTC_447 ml7 120 µM -1.46036748393121 0.0700186997752085 no 3114 0.0720945521413973 4527 4216 Selective myosin light chain kinase inhibitor. SGTC_448 monastrol 171 µM -1.46091302470522 0.0699439841892585 no 3115 0.07201965587412 4386 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_203 k066-0004 30.888 µM -1.46170301428453 0.0698358984073224 no 3116 0.0719113054451562 4531 6795412 SGTC_1286 0929-0070 131 µM -1.46289911156833 0.0696724939889844 no 3117 0.0717474935796959 4532 1420408 SGTC_86 0417-1630 471.922 µM -1.46486174817638 0.0694050070080331 no 3118 0.071479320457531 4449 3634867 SGTC_1822 st052468 42 µM -1.47000029543785 0.0687084227988884 no 3119 0.0707808369840733 4494 2873678 SGTC_2274 7947094 46.08 µM -1.4747772002091 0.0680657101430617 no 3120 0.0701362264294042 4435 2971028 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.47704972822801 0.06776158483463 no 3121 0.069831153884964 4354 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_340 k038-0059 454 µM -1.4779799524405 0.0676373990215958 no 3122 0.0697065721378779 4461 23733424 SGTC_2556 citropten 84.59 µM -1.47859950809281 0.0675547853613168 no 3123 0.0696236921399326 4486 2775 A potential DNA crosslinker. SGTC_622 1348-1566 26.3 µM -1.48410912912822 0.0668235397386604 no 3124 0.0688899858555137 4478 7340407 SGTC_136 0097-0015 404.482 µM -1.49036706533297 0.0660004214921541 no 3125 0.0680638736590912 4480 4861337 SGTC_422 cantharidin 155 µM -1.4912863850016 0.0658801662923807 no 3126 0.0679431609697913 4404 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3232 9132874 49.47 µM -1.49140082042062 0.0658652090123057 no 3127 0.0679281464272442 4459 3784940 SGTC_421 streptovitacin 30 mM -1.49249369517853 0.0657224973849571 no 3128 0.0677848844283844 4487 91467 include heat shock SGTC_631 k072-0230 41.5 µM -1.49566079769648 0.0653102791477922 no 3129 0.0673710355043882 4485 5773147 SGTC_1067 clotrimazole 1.36 µM -1.50318922725686 0.0643384585620541 no 3130 0.0663951273557778 4525 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2034 5197015 53.07 µM -1.50691360812097 0.0638618635356072 no 3131 0.065916401446542 4492 780676 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.51234888883517 0.0631712643150831 no 3132 0.06522256502041 4550 165506 SGTC_1329 1447-1697 50.6 µM -1.51551760893762 0.0627713428569224 no 3133 0.0648206872058852 4507 2840515 SGTC_2268 7933382 153.85 µM -1.52002918153788 0.0622053487663854 no 3134 0.0642518208129049 4539 935025 YOR257W CDC31 SGTC_1951 sophoraflavanone G 9.2 µM -1.52589224963673 0.0614757620807122 no 3135 0.0635183505921648 4448 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_347 4534-1311 26.2 µM -1.53428468446017 0.060443078311181 no 3136 0.0624798159434072 4533 2862016 SGTC_3089 9117425 49.47 µM -1.53478542514052 0.0603818942283353 no 3137 0.0624182720319953 4494 9401657 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.54139781490003 0.0595784834165415 no 3138 0.0616099977623092 4441 5711223 A potent inhibitor of glutathione S-transferases. SGTC_140 0062-0056 502.533 µM -1.54398141434262 0.0592668595182334 no 3139 0.061296417588422 4430 3758964 SGTC_2822 7994718 71.43 µM -1.54429432546054 0.0592292043059955 no 3140 0.0612585233237125 4514 1018011 SGTC_372 0155-0182 15.9 µM -1.55308496105872 0.0581790011300952 no 3141 0.0602014192301644 4406 771486 SGTC_3178 9107506 49.47 µM -1.55531869865925 0.0579144849667346 no 3142 0.0599350930995829 4498 8897194 SGTC_673 1082-0474 110 µM -1.55625459791153 0.0578039384551036 no 3143 0.0598237815185384 4510 3098046 SGTC_1340 1486-1359 257 µM -1.56329009522078 0.0569782226433835 no 3144 0.0589921884729743 4481 4309068 SGTC_2256 7954252 200 µM -1.56535310976066 0.0567378675936101 no 3145 0.0587500682852444 4532 2972920 SGTC_2845 9003024 42.97 µM -1.56604796098 0.0566570928005996 no 3146 0.0586686947449368 4557 2990173 SGTC_2882 9058044 58.44 µM -1.57121053094432 0.0560597901547392 no 3147 0.0580668773776155 4545 18076804 SGTC_482 fipronil 114 µM -1.57916649191555 0.0551490325949563 no 3148 0.057148936775968 4649 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_828 2074-0507 139 µM -1.58127312474123 0.0549098438331552 no 3149 0.0569078009044417 4578 X828 SGTC_460 trequinsin 123 µM -1.58475103248985 0.0545167543046063 no 3150 0.0565114560108749 4618 5537 A vasodilator. SGTC_946 3434-1334 87.4 µM -1.58539079205047 0.0544446886037602 no 3151 0.0564387859840799 4508 4047976 SGTC_3312 9133330 71.43 µM -1.58869982245178 0.054073145002065 no 3152 0.0560640895266282 4544 17617324 SGTC_256 clotrimazole 625 nM -1.58929611551068 0.054006406098462 no 3153 0.0559967776649133 4485 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1361 1608-0041 5.61 µM -1.59104478100177 0.0538110661642132 no 3154 0.0557997490771441 4547 X1361 SGTC_3282 9108498 15.4605 µM -1.5970692632843 0.0531423645380498 no 3155 0.0551251343665721 4531 16459645 SGTC_2868 9035608 32.47 µM -1.60046706794563 0.0527681331023104 no 3156 0.0547475034883612 4540 6462614 SGTC_2798 7813637 45.45 µM -1.60310287696992 0.052479269806767 no 3157 0.0544559714772243 4535 956368 SGTC_926 2268-1401 59.4 µM -1.60968403052705 0.0517635072630601 no 3158 0.0537334264954944 4523 2931578 SGTC_3138 9097216 49.47 µM -1.60983086427409 0.0517476266461679 no 3159 0.0537173926325026 4480 25237486 SGTC_2408 sulbentine 18.36 µM -1.62762513695899 0.0498516084902617 no 3160 0.0518021978737565 4417 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2062 5245942 200 µM -1.63090694045714 0.0495080540917755 no 3161 0.0514549785302527 4600 1376160 SGTC_613 3914-0030 117 µM -1.63153326260619 0.0494427030251346 no 3162 0.0513889235890663 4288 1145395 SGTC_1911 st060208 74.3 µM -1.63372277893799 0.0492147877114119 no 3163 0.0511585365627769 4568 688783 SGTC_2992 9074591 71.4286 µM -1.63755831511168 0.0488175546481232 no 3164 0.0507569323698727 4501 17741321 SGTC_3051 9093778 49.47 µM -1.63802065120008 0.0487698456534348 no 3165 0.0507086929572168 4663 17217378 SGTC_1223 0764-0573 147 µM -1.63898550379912 0.0486704014338526 no 3166 0.050608139378478 4563 1609797 SGTC_3016 9080866 49.47 µM -1.64177910531937 0.048383387866744 no 3167 0.0503178954001393 4547 17066299 SGTC_1860 st056228 74.6 µM -1.64351656958207 0.0482055652962409 no 3168 0.0501380499754067 4557 688679 SGTC_1194 1488-0194 225 µM -1.64474379662874 0.0480802788708363 no 3169 0.0500113284438832 4554 1391452 SGTC_1062 mesoridazine 14.2 µM -1.64613832572845 0.0479382291731837 no 3170 0.0498676417005307 4620 4078 A neuroleptic. SGTC_1094 duloxetine 25.4 µM -1.65821678320369 0.0467219013036857 no 3171 0.0486368592114055 4579 60834 A selective serotonin reuptake inhibitor. SGTC_3223 9129970 49.47 µM -1.66535662776272 0.0460146269728998 no 3172 0.0479208135299973 4582 17248386 SGTC_1667 st014849 34.6 µM -1.66892742499306 0.0456641435974181 no 3173 0.0475658818544416 4663 5348460 SGTC_1383 3049-0032 20.7 µM -1.67046922629825 0.045513476486386 no 3174 0.0474132815543896 4608 712864 SGTC_629 3448-6466 76.7 µM -1.67481097371908 0.0450913414330136 no 3175 0.0469856625577636 4601 573744 SGTC_2855 9016525 58.44 µM -1.67706648107887 0.0448732920422088 no 3176 0.0467647412066007 4522 43811474 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.68027120647764 0.0445649385611797 no 3177 0.046452280292063 4653 688801 SGTC_908 3448-7491 47.7 µM -1.68570917576073 0.0440456134073106 no 3178 0.0459259143334924 4582 1203031 SGTC_970 1315-0089 19.5 µM -1.68747986355057 0.0438775700492607 no 3179 0.0457555593321614 4566 6811083 YLR033W RSC58 SGTC_2451 5856223 45.7 µM -1.68763368008128 0.0438629968639117 no 3180 0.0457407849008481 4578 2179896 SGTC_348 k064-0012 10.7 µM -1.68971903947272 0.0436658066981333 no 3181 0.045540859486718 4545 5066323 SGTC_1397 3532-0190 20.1 µM -1.69922656222294 0.0427758290336995 no 3182 0.0446382517032041 4585 5322280 SGTC_2726 cimetidine 79.27 µM -1.70582686894797 0.0421666552030522 no 3183 0.0440201594614386 4610 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2529 gangaleoidin 93.61 µM -1.70813269387861 0.0419555015942797 no 3184 0.043805861865851 4566 4565183 SGTC_1857 st056007 79.3 µM -1.71364401998323 0.0414542745714058 no 3185 0.0432970618890678 4585 619834 SGTC_306 1672-3436 11.6 µM -1.71512080233986 0.0413207962273121 no 3186 0.0431615405605722 4595 6797378 SGTC_708 3448-5400 146 µM -1.71787650835763 0.0410726545500388 no 3187 0.0429095712687362 4553 3462195 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.71812555917433 0.0410502880648437 no 3188 0.042886857877915 4570 551469 SGTC_392 N-ethylmaleimide 8.33 µM -1.71858980714149 0.0410086217556241 no 3189 0.0428445444812407 4570 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_639 0833-0042 114 µM -1.72423214650685 0.0405049577819798 no 3190 0.0423329715107266 4611 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_254 nsc-64875 3.808 µM -1.72676004729036 0.040280939274139 no 3191 0.0421053832526961 4602 56993 SGTC_3029 9088683 49.47 µM -1.72796465707506 0.0401745432532927 no 3192 0.0419972804985346 4602 25236615 SGTC_330 1488-0319 80.1 µM -1.73256760154429 0.0397700935405529 no 3193 0.041586275955718 4621 6846614 SGTC_3145 9085516 49.47 µM -1.734378082292 0.0396119207495496 no 3194 0.0414255106795417 4583 25236195 SGTC_2957 9076800 11.52 µM -1.74251947331444 0.038906958908437 no 3195 0.0407087935045077 4592 16459615 SGTC_455 paf C-16 10 µM -1.74675149921948 0.0385445641095071 no 3196 0.040340226473755 4581 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3169 9102970 49.47 µM -1.7522870963132 0.0380746998197567 no 3197 0.0398622268589149 4660 17027839 SGTC_2710 st078562 53.7235 µM -1.75555514664326 0.0377995063746376 no 3198 0.0395821982991051 4597 17250908 SGTC_2801 7907800 81.82 µM -1.7576248980405 0.0376260595013248 no 3199 0.0394056770312528 4584 6620925 SGTC_1802 st050112 57.9 µM -1.76268748413819 0.0372045479439162 no 3200 0.0389766064128137 4628 4662563 SGTC_1974 st069448 26.9 µM -1.76724596825643 0.0368283166939091 no 3201 0.038593522161296 4610 6323587 YNR016C ACC1 SGTC_647 0140-0236 81 µM -1.76800947558666 0.036765606385337 no 3202 0.0385296597872623 4634 990837 SGTC_2922 7999257 32.47 µM -1.77363907879197 0.0363059127573727 no 3203 0.0380614346621359 4588 2988377 SGTC_3317 9138495 8.753 µM -1.77418155937622 0.0362618653278417 no 3204 0.0380165617249195 4537 17020139 SGTC_3325 9138760 55.175 µM -1.77458556798322 0.0362290897444341 no 3205 0.037983170967155 4562 43844959 SGTC_441 propafenone 146 µM -1.78410521843635 0.0354637918578462 no 3206 0.037203284743739 4613 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2732 terfenadine 20 µM -1.78476793757622 0.0354110122162843 no 3207 0.0371494830022335 4690 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2736 butenafine 14.65 µM -1.79398859734171 0.034683329526243 no 3208 0.0364074944261188 4566 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2191 5911152 200 µM -1.79457416663197 0.0346375349339075 no 3209 0.0363607860653825 4640 2875902 SGTC_1719 st032227 49.2 µM -1.79935232055296 0.0342657112244497 no 3210 0.0359814833226329 4612 3125804 SGTC_1460 k062-0059 9.15 µM -1.80213203882428 0.0340509143083624 no 3211 0.0357623170121374 4508 1373085 SGTC_2236 dapsone 200 µM -1.80251766030712 0.0340212038565606 no 3212 0.0357319993538967 4654 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_78 0336-0123 156.75 µM -1.80555617960893 0.0337878442392915 no 3213 0.0354938463516306 4507 6765896 SGTC_2679 rapamycin 1 nM -1.80838091423618 0.0335720861372074 no 3214 0.0352736181570234 4484 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3123 9126162 49.47 µM -1.81285560730223 0.0332326234215249 no 3215 0.0349270473440387 4616 25239884 SGTC_2925 9010536 32.5 µM -1.81619020221478 0.0329814944305507 no 3216 0.0346706002638012 4567 2994177 SGTC_1173 0443-0020 122 µM -1.81935226945605 0.0327448051903089 no 3217 0.0344288518490701 4615 5331295 SGTC_1614 st002383 48.6 µM -1.82271687286122 0.0324944952916247 no 3218 0.0341731417234883 4666 1947235 SGTC_1296 1068-0102 11.9 µM -1.82329543623556 0.0324516124883037 no 3219 0.0341293285792336 4639 767053 SGTC_1804 st050076 49.1 µM -1.83379649499553 0.0316813599564869 no 3220 0.0333421041125863 4657 3895976 SGTC_2200 6600604 21.907 µM -1.83461038504655 0.031622297313559 no 3221 0.0332817194171038 4664 2904777 SGTC_1844 rapamycin 4 nM -1.83770597650029 0.0313984860658123 no 3222 0.0330528713667186 4480 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3056 9094900 49.47 µM -1.83885676020516 0.0313156190543677 no 3223 0.0329681285592344 4622 25236784 SGTC_1523 st012844 44.7 µM -1.8505872436964 0.0304811898663058 no 3224 0.032114478134584 4657 4274103 SGTC_1341 1486-1360 280 µM -1.85130883057939 0.0304304680901661 no 3225 0.0320625682102473 4648 3976547 SGTC_2302 7771753 200 µM -1.855921379579 0.0301078925255796 no 3226 0.0317323825646185 4611 2203047 SGTC_1862 st057513 3.81 µM -1.85791172215376 0.0299695774474671 no 3227 0.031590775739021 4642 5393163 SGTC_2016 5121758 140 µM -1.86031239592315 0.0298034487084275 no 3228 0.0314206703897365 4560 2795203 SGTC_2638 epoxomicin 18 µM -1.86176932041787 0.0297030012709272 no 3229 0.0313178063484053 4614 9915668 A protesome inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.87609054090939 0.0287304990827925 no 3230 0.0303214241732917 4735 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2155 5570423 76 µM -1.88093582152991 0.0284075276530003 no 3231 0.0299903248182186 4644 797402 SGTC_2114 5491910 81.25 µM -1.88531819474527 0.0281180195583493 no 3232 0.0296934455575198 4651 2849228 SGTC_1438 4092-1045 4 µM -1.90209513530362 0.0270323120624696 no 3233 0.0285793591688691 4692 1351342 SGTC_2706 st078239 82.5 µM -1.90413507465487 0.0269027169183351 no 3234 0.0284462973629265 4644 15434492 SGTC_407 eburnamonine 100 µM -1.91703414300734 0.0260952090077669 no 3235 0.02761679709395 4544 3195 SGTC_3197 9113331 49.47 µM -1.9188319452183 0.0259842891038876 no 3236 0.0275028027935554 4631 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_381 3461-2219 42.7 µM -1.92000484480824 0.0259121369328278 no 3237 0.0274286437238308 4645 2883159 SGTC_921 1561-0023 372 µM -1.92562948349906 0.0255684566238733 no 3238 0.0270753272820099 4637 24050882 SGTC_543 3844-1095 191 µM -1.93029317528616 0.0252863946519474 no 3239 0.0267852610950744 4679 4230703 SGTC_337 1315-0038 354 µM -1.93412665366011 0.0250565008096479 no 3240 0.0265487787804884 4656 1626437 SGTC_952 1185-0122 232 µM -1.93565679892426 0.0249652284635484 no 3241 0.0264548744322746 4630 678600 SGTC_1483 3453-0561 55.9 µM -1.93768109677789 0.0248449086623572 no 3242 0.0263310707863259 4697 4546991 SGTC_2993 9054257 71.4286 µM -1.93861718631808 0.0247894342247722 no 3243 0.0262739846292371 4597 6470217 YGL055W OLE1 SGTC_2966 9084041 48.03 µM -1.94954322781302 0.0241495846440368 no 3244 0.0256152928515568 4618 17741380 SGTC_1260 0700-1617 7.75 µM -1.95140027599524 0.0240422237577622 no 3245 0.0255047243392659 4630 2853078 SGTC_2832 7992762 51.95 µM -1.95259518693156 0.0239733550408746 no 3246 0.0254337909687158 4585 2985177 SGTC_1441 4106-0040 13 µM -1.96028035212744 0.0235343711659966 no 3247 0.0249815156059724 4719 2904180 SGTC_1783 st039459 87.517 µM -1.96136446969368 0.0234729929701271 no 3248 0.0249182608084678 4701 729761 SGTC_723 4182-0001 115 µM -1.96700907125834 0.0231555912177137 no 3249 0.0245910824966203 4667 744821 YLR208W SEC13 SGTC_1910 st062352 60.4 µM -1.97393383649299 0.0227711476700378 no 3250 0.0241946333486195 4602 2245730 SGTC_3355 9151058 44.0485 µM -1.97885179059571 0.0225013950177256 no 3251 0.023916347725101 4686 17015728 SGTC_1993 st073995 70.8 µM -1.98100338714853 0.0223842287912797 no 3252 0.0237954468700814 4662 3098394 SGTC_2682 pyrogallin 40.03 µM -1.98302448120848 0.0222746382750374 no 3253 0.0236823475235644 4703 822798 An ATP competetive kinase inhibitor. SGTC_1190 1486-1332 13 µM -1.98880424276687 0.0219637354892541 no 3254 0.0233614071525774 4703 4150046 SGTC_1904 st060225 78 µM -2.01613708100403 0.0205426475760909 no 3255 0.0218928217539831 4672 66595 SGTC_1613 st002381 52.1 µM -2.02067761842751 0.020314288607018 no 3256 0.0216565740962556 4701 551167 SGTC_2280 7785178 200 µM -2.02220944863849 0.0202377347306188 no 3257 0.0215773592840029 4680 2954328 SGTC_556 4058-0063 51.5 µM -2.03669178415563 0.0195259853635499 no 3258 0.0208404691832895 4694 6615692 SGTC_2895 9054447 58.44 µM -2.03810736814181 0.0194575697861912 no 3259 0.0207695982310288 4729 2697450 SGTC_1867 st057372 64 µM -2.03957626067835 0.019386793181034 no 3260 0.0206962742441541 4681 688837 SGTC_3140 9094243 49.47 µM -2.04127386741867 0.0193052688829442 no 3261 0.0206118065313806 4661 19291112 SGTC_1964 st076914 61 µM -2.04138493898541 0.0192999450540053 no 3262 0.0206062901431438 4719 24208661 SGTC_58 0957-0393 9 µM -2.04414724575516 0.0191679442917282 no 3263 0.0204695014680628 4220 6997992 SGTC_137 0438-0332 85.389 µM -2.04842141157325 0.0189652100270277 no 3264 0.0202593626505514 4637 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1366 1683-0113 21.9 µM -2.05025968832822 0.0188785785139552 no 3265 0.0201695480602115 4699 708623 SGTC_1186 1319-0216 26 µM -2.0517137002213 0.0188102947134003 no 3266 0.0200987472547769 4720 4565136 SGTC_2059 5238311 157 µM -2.0542620183869 0.0186911266113929 no 3267 0.0199751693655736 4659 703021 SGTC_1362 1611-0397 101 µM -2.0624835541256 0.0183110307188783 no 3268 0.0195808608569639 4710 27816 SGTC_138 0850-0259 40.9225 µM -2.06675847419327 0.0181160094806597 no 3269 0.0193784590897472 4636 6813004 SGTC_3187 9109394 49.47 µM -2.07355744597033 0.0178094891177269 no 3270 0.019060215378873 4689 17098090 SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.07529455415785 0.0177318878229039 no 3271 0.0189796219341142 4704 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1886 st057356 49.9 µM -2.07737420297633 0.0176393639375697 no 3272 0.0188835176246178 4695 24207747 SGTC_818 4072-2707 53.5 µM -2.08319579350739 0.0173825486892511 no 3273 0.018616690194766 4656 882871 SGTC_2333 9017922 200 µM -2.08629234839897 0.0172472521208163 no 3274 0.0184760746785862 4668 3163164 SGTC_2642 cholecalciferol 100 µM -2.08933043670158 0.0171153854723315 no 3275 0.0183389941844232 4706 9821465 A vitamin D precursor, similar to steriods. SGTC_872 0588-0139 234 µM -2.08976608448538 0.0170965472227782 no 3276 0.0183194086822344 4683 2047100 SGTC_40 0327-0103 19.753 µM -2.09106868940258 0.0170403257505197 no 3277 0.0182609534850779 4570 409036 SGTC_1065 prochlorperazine maleate 2.48 µM -2.10006902193584 0.0166561659865664 no 3278 0.0178613849498845 4737 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2892 9047358 58.44 µM -2.11042137886362 0.0162234848381138 no 3279 0.0174110383038394 4705 6466771 SGTC_2958 9077254 16.72 µM -2.12974575815039 0.0154415414747532 no 3280 0.0165963045098728 4698 16457351 SGTC_2013 4024628 200 µM -2.13107806223147 0.0153888439196654 no 3281 0.0165413558446875 4703 5230760 SGTC_1868 st057644 42.7 µM -2.13504257442077 0.015232945240678 no 3282 0.0163787663270068 4729 688665 SGTC_767 0929-0023 86 µM -2.13649180847433 0.0151762958003238 no 3283 0.0163196739762413 4729 1204563 SGTC_980 1473-0395 201 µM -2.13728258166645 0.0151454614790266 no 3284 0.0162875073549673 4686 768876 SGTC_297 0986-0032 24 µM -2.14940217187196 0.0146795789107281 no 3285 0.015801266718779 4703 2847425 SGTC_770 0389-1121 67.2 µM -2.15910539142597 0.0143155207071478 no 3286 0.0154209957425323 4736 6753108 SGTC_1431 4049-0260 9.09 µM -2.16304644713724 0.0141698906636552 no 3287 0.015268803695446 4742 3854841 SGTC_165 k038-0023 64.381 µM -2.18771837537437 0.0132869070328669 no 3288 0.0143450613622111 4689 46368543 SGTC_469 w7 172 µM -2.18833146500297 0.0132655844075111 no 3289 0.0143227332585533 4765 45115570 A P450 inhibitor. SGTC_148 3253-0744 288.01 µM -2.19058143042795 0.0131875860302526 no 3290 0.0142410480755205 4649 6893655 SGTC_1337 1486-1011 40.3 µM -2.19564625990178 0.013013454948567 no 3291 0.0140586362116845 4729 X1337 SGTC_524 r073-0010 27.8 µM -2.19609701271286 0.0129980546309922 no 3292 0.0140425001846495 4686 2772106 SGTC_1415 3966-0071 78.1 µM -2.19862210495073 0.0129120739518321 no 3293 0.0139524019258363 4671 2893185 SGTC_1954 st077032 68.9 µM -2.20380330604336 0.0127371902958533 no 3294 0.0137690899916639 4675 698907 SGTC_378 3970-0959 8.33 µM -2.23508584788318 0.0117242308528639 no 3295 0.012705856646951 4719 6615653 SGTC_142 0335-0849 62.6745 µM -2.24248159404539 0.0114952304719193 no 3296 0.0124651317904637 4682 3889043 YPR107C YTH1 SGTC_1440 4100-1550 40 µM -2.24382427774064 0.0114540752194961 no 3297 0.0124218548530232 4746 742806 SGTC_1372 2752-0194 270 µM -2.2454958143112 0.0114030190420591 no 3298 0.0123681603216156 4689 823334 SGTC_3351 9150312 21.596 µM -2.25337165922379 0.011165107542224 no 3299 0.01211786246373 4684 4904905 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.26117343684939 0.0109337005231775 no 3300 0.0118742596558489 4705 5379071 SGTC_3213 9129884 49.47 µM -2.2627592465734 0.0108871778637776 no 3301 0.0118252671935638 4698 17190742 SGTC_557 1315-0110 16.2 µM -2.26785654504265 0.0107388040690564 no 3302 0.011668975830884 4723 6833801 SGTC_3285 9112818 20.8695 µM -2.28748985774166 0.0101836401287571 no 3303 0.0110836233782466 4736 17017947 YPR165W RHO1 SGTC_173 1273-0061 2.693 µM -2.29159651336267 0.0100707366060807 no 3304 0.0109644684329963 4696 2847414 YPL266W DIM1 SGTC_2510 benzyl isothiocyanate 8.31 µM -2.29557771405162 0.00996232652806249 no 3305 0.0108500191147203 4749 2346 DNA damaging agent; causes G2/M arrest. SGTC_1703 st026983 48.3 µM -2.29627416041346 0.00994346700927733 no 3306 0.0108301052864622 4753 1104023 SGTC_144 4161-2749 112.381 µM -2.30748842189717 0.00964405249729939 no 3307 0.0105138034785283 4749 797501 YMR168C CEP3 SGTC_2595 hexamethylquercetagetin 100 µM -2.32620201677241 0.00916193629271395 no 3308 0.010003888068248 4701 386331 SGTC_375 3970-0961 9.27 µM -2.34453660788704 0.00871018038508224 no 3309 0.00952537012158022 4736 2898222 SGTC_414 piperonyl butoxide 100 µM -2.36657082461632 0.00819320378713138 no 3310 0.0089768693678597 4753 5794 A potent inhibitor of cytochrome P450. SGTC_2777 climbazole 1.536 µM -2.37830941538218 0.00792895084788612 no 3311 0.00869611250775468 4561 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2923 7992654 58.14 µM -2.38084763872599 0.00787280730620384 no 3312 0.00863642723040122 4718 2985126 SGTC_3222 9128301 49.47 µM -2.39247573014321 0.00762004961607059 no 3313 0.00836756743167739 4708 4911358 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -2.44174292832346 0.00662669620202808 no 3314 0.00730827533878134 4757 1609 A potent and irreversible inhibitor of serine proteases. SGTC_179 1273-0063 6.77 µM -2.44828000730486 0.00650389069757191 no 3315 0.00717700281488338 4728 3108139 SGTC_3300 9124615 50.48 µM -2.45150491563201 0.0064440524290843 no 3316 0.00711301216986558 4733 24824903 SGTC_1429 4049-0205 9.46 µM -2.4655183238467 0.00618965311955198 no 3317 0.00684075885771171 4785 22774478 SGTC_1863 st057641 20.1 µM -2.49265429186503 0.00572219754568533 no 3318 0.00633961147316569 4774 3921635 SGTC_3151 9099821 49.47 µM -2.51267932992955 0.00539760906627613 no 3319 0.00599090954088533 4726 17174189 SGTC_2643 anethole 100 µM -2.53121102132808 0.00511191761249602 no 3320 0.00568347197628383 4772 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_969 1313-0238 134 µM -2.53992231358769 0.0049823334274816 no 3321 0.00554385470611423 4768 5212874 SGTC_37 0566-0070 1.56 µM -2.57635858102749 0.00447148489867563 no 3322 0.00499235199858038 4730 1626686 SGTC_1522 st012842 45.6 µM -2.58279931059562 0.00438621524559182 no 3323 0.00490011562402899 4676 3491067 YOR116C RPO31 SGTC_3348 9149464 3.537 µM -2.62951599392665 0.00380999540942596 no 3324 0.00427532548103299 4760 1951442 SGTC_1448 4255-0083 152 µM -2.63723981062375 0.00372155620518073 no 3325 0.00417918595406236 4778 5399660 SGTC_2118 5526350 200 µM -2.64444961113912 0.00364066873459254 no 3326 0.00409119442277478 4771 743594 SGTC_1900 st060200 72.8 µM -2.65055572281453 0.00357340129186968 no 3327 0.00401797350961489 4768 688945 SGTC_2786 7743617 45.45 µM -2.65556387223442 0.0035190645738261 no 3328 0.00395879689848285 4739 583674 SGTC_177 1327-0068 8.361 µM -2.67347600474649 0.00333074430375417 no 3329 0.00375348232403968 4776 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2241 6772625 37.8075 µM -2.70281269141737 0.00304181282630656 no 3330 0.00343777398364756 4659 2285411 SGTC_1444 4112-3581 28 µM -2.72463940811325 0.00284170943413961 no 3331 0.00321858741216571 4801 2877249 SGTC_1052 3253-3998 198 µM -2.72786885995725 0.00281313273225227 no 3332 0.00318724722670957 4763 5450317 SGTC_984 1492-0255 2.91 µM -2.75504303731759 0.00258275457504732 no 3333 0.00293422078304413 4766 1585198 SGTC_2082 5219693 150 µM -2.77070314085565 0.00245787038099019 no 3334 0.00279676985374356 4760 2834649 SGTC_1463 k081-0032 34.1 µM -2.779478156977 0.00239030512434677 no 3335 0.00272231575606195 4402 977755 SGTC_2140 5586273 200 µM -2.79251071511046 0.00229305705138201 no 3336 0.00261503676896603 4785 854421 SGTC_755 1995-0008 37.3 µM -2.8208164695806 0.00209407481386647 no 3337 0.0023950799651141 4783 689533 SGTC_2849 9019321 12.99 µM -2.82887340238854 0.00204037369012281 no 3338 0.00233560864941861 4771 16489627 SGTC_1518 st038567 90.8 µM -2.84812798735673 0.0019170642984115 no 3339 0.00219886173594953 4765 77966 SGTC_3211 9128781 49.47 µM -2.85215622680191 0.00189213937147154 no 3340 0.0021711876634248 4721 17194361 SGTC_783 0848-0141 92.7 µM -2.86139102490847 0.00183610641029235 no 3341 0.00210893239476279 4766 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_166 k072-0058 166.424 µM -2.89504647232809 0.00164443480151595 no 3342 0.00189551201716076 4728 5846229 SGTC_786 4544-0069 423 µM -2.91046707479113 0.00156285736778251 no 3343 0.00180444494280436 4785 748821 YLR208W SEC13 SGTC_167 3672-0051 66.205 µM -2.93167702126236 0.00145667638043973 no 3344 0.00168568582489178 4756 3237971 SGTC_913 3487-1245 167 µM -2.99199158013802 0.0011897010510382 no 3345 0.00138581953671621 4770 4016153 SGTC_1850 st056238 17 µM -3.08902177583054 0.000852661574791974 yes 3346 0.00100408359692859 4788 5393177 SGTC_1706 st031321 9.9705 µM -3.09109944814037 0.000846517048029789 yes 3347 0.000997084163718952 4800 6103185 SGTC_2864 9034755 47.6 µM -3.12454774262883 0.000753040627785181 yes 3348 0.000890393103870312 4785 4930451 SGTC_1898 st060199 18.6 µM -3.16401636147504 0.000655007927421604 yes 3349 0.000778040237061722 4794 688866 SGTC_2663 amphotericin b 100 µM -3.24096063393929 0.000496896815614259 yes 3350 0.000595638167890139 4802 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2071 5230951 39.92 µM -3.33698200497835 0.000349154249285968 yes 3351 0.000423467157715223 4799 1799272 SGTC_1462 k081-0014 26.5 µM -3.40039256477119 0.000275211567270821 yes 3352 0.000336445862529116 4475 3270634 SGTC_3192 9110362 49.47 µM -3.44285321529525 0.000234155633510449 yes 3353 0.000287805821732415 4798 16649480 SGTC_3200 9114385 49.47 µM -3.64743539618508 0.000104873464718655 yes 3354 0.000132435439862927 4792 17018030 YLR208W SEC13 SGTC_77 0828-0286 12.516 µM -3.90444866531676 3.60582890613671e-05 yes 3355 4.72202174992026e-05 4790 745345 SGTC_3208 9114115 49.47 µM -4.52227763702525 2.11728444097798e-06 yes 3356 3.05888708462888e-06 4801 650895