SGTCid condition conc unit MTH1|YDR277C.score MTH1|YDR277C.strain.pval MTH1|YDR277C.strain.significant MTH1|YDR277C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2568 diosmetin 100 µM 8.12717410048069 5.86543564940505e-18 yes 1 2.19707019032229e-16 2 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2002 4023503 131 µM 6.29319471628773 1.78275011329393e-11 yes 2 1.55498909326945e-10 6 4736863 YCR052W RSC6
SGTC_2569 tetrandrine 100 µM 5.74988926729485 7.33169214925356e-10 yes 3 4.46509588988668e-09 3 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 5.65096229104345 1.3934973278781e-09 yes 4 7.97760468691056e-09 8 1377
SGTC_2537 larixol 68.93 µM 5.64038477685429 1.49160539325162e-09 yes 5 8.48352888167234e-09 6 6708759
SGTC_1563 conessine 56.1 µM 5.26160641204452 1.57409246992255e-08 yes 6 7.14011009628058e-08 3 441082 An anti-amoebic, histamine inhibitor.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 4.81651562463533 2.05799085581503e-07 yes 7 7.30433654087539e-07 10 688761
SGTC_1852 st056254 31.4 µM 4.42589801292491 1.64767757351016e-06 yes 8 4.8020947491716e-06 6 442583
SGTC_1986 st071812 45 µM 4.42409159358491 1.66297190789232e-06 yes 9 4.84244637420612e-06 2 11838594
SGTC_1569 carminic acid 40.6 µM 4.30026987593494 3.10683501608049e-06 yes 10 8.52951178080031e-06 12 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_457 grayanotoxin iii 135 µM 3.9114607803547 1.98795566702696e-05 yes 11 4.58697777219915e-05 69 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 3.76847561574095 3.77810715087646e-05 yes 12 8.21237631742559e-05 33 5282309
SGTC_433 pimozide 108 µM 3.4833963129288 0.000127413809746841 yes 13 0.000247547430179246 30 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2534 helenine 20.12 µM 3.31786387994082 0.00024813885967242 yes 14 0.000453543390291726 25 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_426 0988-0037 14.6 µM 3.21397140989972 0.000371535995242812 yes 15 0.000654563538180368 66 5383008
SGTC_932 2857-0803 154 µM 3.16409863890167 0.000449172200078378 yes 16 0.000777820312715896 60 674898
SGTC_1212 0520-0165 585 µM 3.04113091001176 0.000709241420934395 yes 17 0.0011784566608102 84 5403258
SGTC_1572 epiandrosterone 68.9 µM 2.97729073060103 0.000893491052853294 yes 18 0.00145404049508907 63 441302 A steroid.
SGTC_533 1222-0222 6.71 µM 2.90004637508569 0.00117486612082112 no 19 0.00186553726974487 76 3982874
SGTC_983 1491-0821 12.2 µM 2.88212916367524 0.00125078811442998 no 20 0.00197498889856947 50 46495113
SGTC_1725 st036284 20.55 µM 2.833602328136 0.00147950062584267 no 21 0.00230132846682637 88 707914
SGTC_2917 7979103 53.79 µM 2.83292807275477 0.00148293136634646 no 22 0.00230618815704539 95 2980565
SGTC_2429 5902844 64.44 µM 2.80692697141029 0.00162089784966196 no 23 0.00250082896386403 109 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1753 st043925 64 µM 2.76369924240331 0.00187636128006092 no 24 0.00285750946450741 55 670181
SGTC_3063 1327-0034 4 µM 2.71041013610551 0.00224140632345241 no 25 0.00336000277822958 102 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2427 5545055 42.75 µM 2.70953989922931 0.00224786819554662 no 26 0.00336883003959059 85 5372858
SGTC_2930 9013230 14.89 µM 2.68360080872407 0.00244839641529488 no 27 0.00364170067867199 138 2995857
SGTC_3065 9113888 49.47 µM 2.66300237747377 0.00261901479944431 no 28 0.0038723433468007 93 16648368
SGTC_907 3448-6986 75.5 µM 2.66292931392151 0.00261963864751391 no 29 0.00387318423006181 108 590582
SGTC_2132 5317594 122.667 µM 2.64811455126438 0.00274894198893345 no 30 0.00404710465743954 90 794577
SGTC_771 0250-0039 27.3 µM 2.64137000366722 0.00280969449475796 no 31 0.00412857439767206 73 3005115
SGTC_2690 usnic acid 100 µM 2.63982103285174 0.00282381699931136 no 32 0.00414749091962753 111 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1512 0259-0544 12.2 µM 2.63231341037137 0.00289317806980404 no 33 0.00424027957214286 106 18476
SGTC_2934 9036370 36.88 µM 2.62232920511952 0.00298779877363393 no 34 0.00436655140735669 121 6462800
SGTC_2419 paclitaxel 166.5 µM 2.61677936810036 0.00304159219858014 no 35 0.00443818473962178 162 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2217 6934799 96.0675 µM 2.61220634193143 0.0030865714692951 no 36 0.00449799699344008 51 675606
SGTC_1467 k284-1082 293 µM 2.60054490980522 0.00320399394747986 no 37 0.00465379177158002 92 3334705
SGTC_1452 4194-0072 190 µM 2.5888134392523 0.00332616220824538 no 38 0.00481536276432956 96 1343545
SGTC_1743 st037606 46.3785 µM 2.58538982675275 0.00336259579088825 no 39 0.00486344767288526 115 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.58512545178711 0.0033654240950558 no 40 0.00486717857990332 84 364106
SGTC_1976 st070609 63.5 µM 2.50376906015879 0.00434440001791027 no 41 0.00614391054146631 86 682556
SGTC_1412 3909-8563 178 µM 2.5011972191472 0.00437912592936497 no 42 0.00618871148737999 99 23767530
SGTC_1225 1216-0074 20.6 µM 2.49793505964447 0.0044235294815497 no 43 0.00624595378135393 115 4241466
SGTC_1477 0139-0234 16 µM 2.48919992006139 0.00454441655756931 no 44 0.00640154743813368 92 620880
SGTC_1413 3910-0535 34.4 µM 2.48533857608388 0.00459878807756551 no 45 0.00647141357741261 94 2876951
SGTC_2572 astragaloside iv 100 µM 2.47248647314338 0.00478396474437989 no 46 0.00670883956733806 136 45006101 An anti-inflammatory agent.
SGTC_1756 st041558 35.5 µM 2.44472285301178 0.00520685147910289 no 47 0.00724817453994496 88 3955792
SGTC_1587 estradiol valerate 56.1 µM 2.44378233240395 0.00522174227266884 no 48 0.00726709624808387 93 13791 A steroid.
SGTC_1111 tnp00062 510.699 nM 2.43683794810147 0.00533286693355676 no 49 0.00740815877295894 107 676306
SGTC_1973 st070275 50.2 µM 2.3971710797705 0.00600885559989303 no 50 0.00826110372944847 104 17118334
SGTC_3080 9117754 49.47 µM 2.38529587436601 0.0062254929663779 no 51 0.0085326950242794 141 9550191
SGTC_2425 5628681 7.85 µM 2.37845617275814 0.00635338323353322 no 52 0.00869265174216641 147 5714958
SGTC_259 usnic acid 108.925 µM 2.37737801881295 0.006373753569395 no 53 0.00871810445628875 140 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1857 st056007 79.3 µM 2.30539238245321 0.0078715590656138 no 54 0.0105723038706468 95 619834
SGTC_381 3461-2219 42.7 µM 2.29211165454217 0.00817944405877399 no 55 0.0109496005268376 150 2883159
SGTC_2601 securinine 100 µM 2.2471609066133 0.00930142431764234 no 56 0.0123148727982665 168 442872 A GABA receptor antagonist.
SGTC_248 streptozotocin 5.23457 mM 2.24409419666125 0.00938265817200605 no 57 0.012413170641845 163 5300 DNA alkylating agent.
SGTC_3257 9139206 32.98 µM 2.2430049810253 0.00941165931155703 no 58 0.0124482466512314 82 4910041
SGTC_823 0417-1665 178 µM 2.23621374057092 0.00959425543617877 no 59 0.0126688867875437 172 3429856
SGTC_1710 st031758 61.5 µM 2.22714430514658 0.00984292988889491 no 60 0.0129688154854461 128 5394341
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.22535763343357 0.00989257684499011 no 61 0.0130286196376686 179 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1373 2887-0003 58.5 µM 2.20708960129833 0.0104128762290839 no 62 0.0136539000626716 178 776948
SGTC_1905 st060207 84.5 µM 2.20703990070259 0.0104143237015631 no 63 0.0136556359365785 128 1948547
SGTC_616 4092-0450 108 µM 2.20663446289106 0.0104261381621025 no 64 0.0136698036237341 177 787165
SGTC_2849 9019321 12.99 µM 2.2042275723046 0.0104965157766828 no 65 0.0137541718102167 191 16489627
SGTC_1842 st055362 61.2 µM 2.19473550269453 0.0107781152269451 no 66 0.0140912882226529 179 676032
SGTC_909 3448-9333 149 µM 2.19106244707384 0.0108888352161439 no 67 0.0142236368873809 142 3344074
SGTC_1085 doxorubicin 7.67 µM 2.1879374379911 0.0109838129813146 no 68 0.0143370798841914 193 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2649 anisomycin 9.56 µM 2.17775961224213 0.0112981592273133 no 69 0.0147119691012439 109 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2404 5161160 200 µM 2.16561592088019 0.0116834269540532 no 70 0.0151702743791832 189 2831543
SGTC_3165 9101544 49.47 µM 2.16228960841969 0.0117909262866132 no 71 0.0152979301027844 162 5002184
SGTC_554 4483-2211 187 µM 2.15286110377762 0.0121003125124048 no 72 0.0156647980935981 178 747107
SGTC_3309 9129340 25.759 µM 2.15057360132959 0.0121764268082868 no 73 0.0157549354187908 175 17158987
SGTC_1689 st020265 53.493 µM 2.14757920269034 0.0122766892360876 no 74 0.0158735995208392 149 5758320 YPR016C TIF6
SGTC_1548 st061468 90.8 µM 2.12787536835742 0.0129544493420933 no 75 0.016673709163879 139 390799
SGTC_1184 1269-1718 139 µM 2.12480372260244 0.0130629691484077 no 76 0.0168014970427924 161 5403821
SGTC_2564 betulinic acid 100 µM 2.12013486072663 0.0132294225575929 no 77 0.0169973369086548 237 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.11951138723753 0.0132517886221048 no 78 0.0170236362193521 124 688803
SGTC_714 4296-0578 26.1 µM 2.10110647721819 0.0139269091844597 no 79 0.0178158102232309 85 1589775
SGTC_1546 5-methoxyflavanone 78.7 µM 2.10049034762832 0.0139500136253953 no 80 0.0178428644121192 167 147795
SGTC_2180 6301957 200 µM 2.09507939563874 0.0141543439248433 no 81 0.0180819676117725 130 845462
SGTC_3068 9116768 49.47 µM 2.09413326518059 0.0141903356560616 no 82 0.018124055256281 192 41904888
SGTC_2606 farnesol 9.78 µM 2.04174693379835 0.0163100803659028 no 83 0.0205883202881646 206 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1439 4092-1168 46 µM 2.02114386228317 0.0172151573929911 no 84 0.0216324374765487 181 2886240
SGTC_3015 9080845 49.47 µM 2.00998821547605 0.0177228838383962 no 85 0.0222162180647237 178 5296973
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.99626101821196 0.0183651338532305 no 86 0.0229527593935388 208 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3337 9144342 33.5465 µM 1.99599413996967 0.0183778141350032 no 87 0.0229672803278326 221 17682949
SGTC_2394 5221648 200 µM 1.9862393681221 0.0188464411992882 no 88 0.023503375722836 260 788586
SGTC_1347 1493-0251 600 nM 1.9749182188752 0.0194030279776508 no 89 0.0241387147556684 240 3986378
SGTC_2260 7964312 200 µM 1.964320574955 0.0199366389555078 no 90 0.0247464635567237 182 231951
SGTC_555 4296-0685 37 µM 1.95532279162272 0.0203994186334435 no 91 0.0252724913574722 227 2908540 YHR072W ERG7
SGTC_1504 k297-0033 30 µM 1.93669411907547 0.0213865274085624 no 92 0.0263913725355667 201 4388117
SGTC_402 epigallocatechin gallate 10 µM 1.93336588526304 0.0215670720007588 no 93 0.0265955703564929 270 65064 An antioxidant.
SGTC_1706 st031321 9.9705 µM 1.93192070549171 0.0216458679068342 no 94 0.0266846468655937 195 6103185
SGTC_325 2810-4341 181 µM 1.93060968401761 0.0217175593545 no 95 0.0267656696901501 203 774970
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.91653931307067 0.0224996876752646 no 96 0.0276482420929106 193 616764
SGTC_1282 0886-0010 32.4 µM 1.91387994549384 0.0226501515310815 no 97 0.0278177487009238 268 2836211 YNL267W PIK1
SGTC_741 4582-0002 126 µM 1.91041608297354 0.0228474038148741 no 98 0.0280398308515655 239 2912688
SGTC_2528 xanthyletin 44.79 µM 1.90377678015638 0.0232295309033468 no 99 0.0284696309228377 229 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_524 r073-0010 27.8 µM 1.90309420995632 0.0232691196716013 no 100 0.0285141266673111 274 2772106
SGTC_2516 gossypol 71.55 µM 1.90095732248669 0.0233934255665464 no 101 0.0286538014239476 253 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2162 5663267 200 µM 1.89608665911666 0.0236788488094305 no 102 0.0289742931911865 211 6456493
SGTC_3143 9086658 49.47 µM 1.88826034064816 0.0241436056668692 no 103 0.0294955043583309 324 25236626
SGTC_3074 9116018 49.47 µM 1.88776451165911 0.0241733062247379 no 104 0.0295287857063176 212 17027303
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.87093171010916 0.0251999608716244 no 105 0.030677273543943 295 5024745
SGTC_2417 cerulenin 830 nM 1.86522219275433 0.0255563874416819 no 106 0.031075133022123 234 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_898 1000-0849 28.3 µM 1.85834287468136 0.0259914384084387 no 107 0.0315601694694149 217 6751807
SGTC_374 0880-0231 82.3 µM 1.85811976543744 0.0260056510161348 no 108 0.0315760042874247 271 6833587
SGTC_1348 1493-0373 93.8 µM 1.85083105356618 0.0264735475215988 no 109 0.0320969310468384 246 3010129
SGTC_2597 laccaic acid a 100 µM 1.82209260527872 0.0283874840029071 no 110 0.0342204677828917 321 5491415 A textile dye.
SGTC_2621 lithochol-11-enic acid 100 µM 1.81937969967232 0.0285739619339075 no 111 0.0344267608115509 321 6708711
SGTC_628 1636-0253 16 µM 1.81765003571957 0.0286933855105455 no 112 0.0345588194446381 313 4456143
SGTC_365 0121-0052 13.6 µM 1.81737403763407 0.0287124799724527 no 113 0.0345799301526714 394 3101739
SGTC_3250 9135583 49.47 µM 1.80509493310082 0.0295727419799299 no 114 0.035529913914626 229 7699353
SGTC_597 k018-0003 82.8 µM 1.79978810444546 0.0299510985675187 no 115 0.0359470514911368 278 6786234
SGTC_476 mead acid 10 µM 1.7914756202143 0.0305518099875535 no 116 0.0366085017366503 181 5312531 An omega 9 fatty acid.
SGTC_1113 artemisinin 1.17947 µM 1.79022385714539 0.0306431288156726 no 117 0.0367089656417045 279 2240 An anti-malaria and mitochondrial poison.
SGTC_1066 ketoconazole 628 nM 1.78935236774684 0.0307068392284477 no 118 0.0367790426315842 320 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2287 7945887 168.79 µM 1.78656348320155 0.0309114587099727 no 119 0.0370040340806683 269 1245853
SGTC_3306 9127676 59.7925 µM 1.78638542888143 0.030924560726965 no 120 0.0370184366217005 292 41905287
SGTC_1023 4482-3888 16 µM 1.78451567451096 0.0310624231902372 no 121 0.0371699550562507 275 3303168
SGTC_3267 9137951 49.47 µM 1.78172289349222 0.0312692898137323 no 122 0.0373972158306157 193 16643986
SGTC_34 0469-0683 81.75 µM 1.77853163023999 0.0315070662675263 no 123 0.0376582908963452 272 3690923
SGTC_2436 5633522 8.09 µM 1.77839797807707 0.0315170570179389 no 124 0.0376692572690594 309 5724242
SGTC_2624 nerol 100 µM 1.77521318861579 0.0317559017480429 no 125 0.0379313464419786 257 637566 A natural product oil.
SGTC_1262 0737-0114 49.6 µM 1.7684892613875 0.0322650788386669 no 126 0.0384895729381324 340 765919
SGTC_1686 st019653 115.5 µM 1.76501946682079 0.0325304574282752 no 127 0.0387802470380325 259 97252
SGTC_3286 9117135 37.221 µM 1.76027354071446 0.0328963507679466 no 128 0.039180719082583 306 3438150
SGTC_2751 anetholtrithion 17.25 µM 1.75642064788123 0.0331958833799539 no 129 0.0395083048935604 313 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_759 3486-0358 89.3 µM 1.75608342216372 0.0332222066526091 no 130 0.0395370826678297 320 875103
SGTC_2989 9073649 71.4286 µM 1.75428104094241 0.0333631891756048 no 131 0.0396911813800947 399 21367202
SGTC_1701 st028638 40.4 µM 1.74291563037319 0.0342635818529242 no 132 0.0406741766740574 306 3490878
SGTC_972 1319-0219 195 µM 1.73383441942473 0.034997287155723 no 133 0.041473733317228 310 23903702
SGTC_1714 st033236 13.627 µM 1.73139331429285 0.0351966973635407 no 134 0.0416908191236531 319 2916566
SGTC_593 1203-0218 61.7 µM 1.72693025254291 0.0355636878878294 no 135 0.0420900952335393 302 3666956
SGTC_406 estrone 100 µM 1.7267184525235 0.0355811815439324 no 136 0.0421091200227305 299 5870 A steroid.
SGTC_1114 scopoletin 1.73284 µM 1.72609272227365 0.0356329050412642 no 137 0.0421653664621824 280 5280460 A coumarin with genotoxic properties.
SGTC_2852 9023854 51.95 µM 1.72480799864622 0.0357392947739847 no 138 0.0422810398997752 321 19798528
SGTC_1370 2001-0092 44.6 µM 1.7241064198104 0.0357975032886118 no 139 0.0423443166805243 370 790957
SGTC_2222 6885208 172.143 µM 1.7207926809965 0.0360734880683483 no 140 0.0426442255085201 224 609514
SGTC_2824 7998404 51.95 µM 1.71181296131107 0.0368301323745732 no 141 0.0434655713478633 297 837851
SGTC_1035 k081-0041 55.2 µM 1.71166176606471 0.0368429825567657 no 142 0.0434795092387059 339 731709
SGTC_2675 theaflavin digallate 100 µM 1.70190565972541 0.0376799425735357 no 143 0.0443865273259997 331 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_669 0108-0021 26.2 µM 1.70052781630936 0.0377993866071383 no 144 0.0445158443882344 467 17201
SGTC_1368 1852-0141 284 µM 1.69682310512864 0.0381220778560697 no 145 0.0448650545645714 336 2838987
SGTC_1476 4112-3294 3.34 µM 1.69509296980856 0.0382735455569396 no 146 0.0450288928329005 312 704369
SGTC_260 nsc-65238 3.989 µM 1.69289231275817 0.0384669145531754 no 147 0.0452379834146816 291 3246252
SGTC_781 4335-2806 94.4 µM 1.6918935801963 0.0385549342564856 no 148 0.0453331331335007 358 845254
SGTC_688 0527-0193 473 µM 1.68211533164999 0.0394254035799523 no 149 0.046273238974367 298 4007154
SGTC_2529 gangaleoidin 93.61 µM 1.67117896323644 0.0404178408263055 no 150 0.0473431670755395 290 4565183
SGTC_2272 7805186 180 µM 1.67069313601742 0.040462394291676 no 151 0.0473911526717876 302 2956062 YPR165W RHO1
SGTC_3217 9129673 49.47 µM 1.6642589607119 0.0410562187473183 no 152 0.0480303449450476 356 17248312
SGTC_2592 piperlongumine 83.33 µM 1.6625627508558 0.041213937411135 no 153 0.0481999962843413 324 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3160 9100216 49.47 µM 1.66231237402558 0.0412372597469366 no 154 0.0482250790065467 297 17191039
SGTC_1690 st023502 41.2 µM 1.65698124901403 0.0417363926150181 no 155 0.0487616330773646 303 24207482
SGTC_435 c-PAF 6.7 µM 1.65461288732452 0.0419596975032484 no 156 0.0490015238326045 370 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3347 9188721 44.724 µM 1.65183509070946 0.0422228380918008 no 157 0.0492840865552465 305 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1100 amiodarone 5.07 µM 1.64806789238929 0.0425818363628731 no 158 0.0496693700356362 373 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2409 alverine citrate 63.97 µM 1.64720610585349 0.0426643069411012 no 159 0.0497578446158149 364 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1819 st053448 58.6 µM 1.6407167526246 0.0432894751089029 no 160 0.0504281128702646 329 2857616
SGTC_2480 5767542 37.17 µM 1.63920329893107 0.043436336173354 no 161 0.050585463514429 329 2867358
SGTC_2048 5246248 200 µM 1.63842554976606 0.0435119629561085 no 162 0.0506664764801704 288 677046
SGTC_1699 st031318 29.054 µM 1.63515575972967 0.0438310742777347 no 163 0.0510081998138528 343 5340658
SGTC_2676 harmalol 100 µM 1.63345288337746 0.043998010588753 no 164 0.0511868912384169 361 5459187 A monoamine oxidase inhibitor
SGTC_2549 cedrol 20.94 µM 1.63315618567003 0.0440271488283741 no 165 0.0512180761202897 288 6708665 A sedative which affects the nervous system.
SGTC_488 nitrendipine 139 µM 1.61773633401539 0.0455630536140401 no 166 0.0528597160686998 366 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_809 3998-0021 90 µM 1.6164775024347 0.0456903192454694 no 167 0.05299555684451 317 715485
SGTC_368 fentichlor 4.58 µM 1.60946499217576 0.0464045098286607 no 168 0.0537573519575713 322 7329 A pesticide.
SGTC_2227 7312221 64.1025 µM 1.60664711378437 0.0466940095880124 no 169 0.0540659005657808 284 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2967 9089538 49.85 µM 1.60499194244591 0.046864730993687 no 170 0.054247788959705 406 728216
SGTC_3296 9122258 64.045 µM 1.60171029510506 0.0472046942015634 no 171 0.0546098437591077 382 4730474
SGTC_3312 9133330 71.43 µM 1.60120603299953 0.0472571081598655 no 172 0.0546656465308694 364 17617324
SGTC_2731 amoxapine 43.43 µM 1.60047353761195 0.0473333281973821 no 173 0.0547467864074469 189 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1122 capsaicin 818.572 nM 1.59844216036087 0.0475452193192582 no 174 0.0549723040334949 369 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2112 5488546 200 µM 1.59250071230063 0.0481693302144241 no 175 0.0556361215929156 380 600757
SGTC_2279 7948423 32.93 µM 1.59166651644629 0.0482574795367609 no 176 0.0557298278163579 317 1247112
SGTC_2487 5918373 44.05 µM 1.59090743595904 0.0483378035300496 no 177 0.0558152044283348 371 2876279
SGTC_369 0957-0393 4.5 µM 1.5888247384811 0.0485587386790147 no 178 0.0560499832419207 360 6997992
SGTC_2047 4141938 200 µM 1.58830965009448 0.0486135042467768 no 179 0.0561081682151065 315 3807862
SGTC_2644 guaiazulene 100 µM 1.58556119324689 0.0489065627022282 no 180 0.0564194426079385 323 3515 A coloring agent.
SGTC_811 0416-0114 265 µM 1.58533792926938 0.0489304304278935 no 181 0.0564447878530102 367 6612453
SGTC_812 4251-0442 148 µM 1.58047152157564 0.0494529829659496 no 182 0.0569994618628613 351 5723007
SGTC_3221 9128209 49.47 µM 1.57864384137448 0.049650385316445 no 183 0.0572088863502592 342 16460723
SGTC_3084 9116877 49.47 µM 1.57627663187528 0.0499069946281894 no 184 0.057481032307307 303 27241325
SGTC_82 0054-0107 293.755 µM 1.5744072960943 0.0501103801606562 no 185 0.0576966590738031 335 3104697
SGTC_773 4358-1457 44.6 µM 1.57200540475691 0.0503726776567136 no 186 0.0579746488881741 440 1186886
SGTC_420 mitomycin C 81.9 mM 1.57136175098903 0.0504431531495299 no 187 0.0580493225774606 404 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2722 naftopidil 47.16 µM 1.56639016791452 0.0509901563398139 no 188 0.0586286516590838 383 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_897 1000-0139 31.4 µM 1.5649491185245 0.0511495887278464 no 189 0.0587974201242128 367 6151020
SGTC_1906 st060206 94.7 µM 1.56297608529135 0.0513685209236212 no 190 0.059029109955046 406 5133468
SGTC_1851 st056236 18.9 µM 1.5583323017296 0.051886747488394 no 191 0.0595772477667997 377 5393171
SGTC_3131 9127911 49.47 µM 1.55623043375178 0.0521226687761264 no 192 0.0598266534552544 387 45595681
SGTC_2514 salinomycin 42.74 µM 1.55530166919453 0.0522271877524633 no 193 0.05993712000792 456 23682228 A polyether potassium ionophore.
SGTC_220 paclitaxel 373.376 µM 1.55477114716626 0.052286964961559 no 194 0.0600002915457441 317 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_162 k030-0015 37.8 µM 1.5545111899666 0.0523162757792027 no 195 0.0600312647945463 371 1809920 YMR134W ERG29
SGTC_810 3825-7150 143 µM 1.54894008690517 0.0529475728526602 no 196 0.060698061632294 395 22330411 YGL099W LSG1
SGTC_2715 st079500 56.4 µM 1.54626825801413 0.0532524708849607 no 197 0.0610198972912259 356 28246688
SGTC_228 caffeine 993.056 µM 1.54472370646958 0.053429362528267 no 198 0.0612065540795614 340 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2216 7189485 200 µM 1.53430913682048 0.0546342875988321 no 199 0.0624768095092552 338 731273
SGTC_772 k072-0172 35.3 µM 1.53320722100491 0.0547630219845831 no 200 0.0626124028214134 361 5861980
SGTC_447 ml7 120 µM 1.52858106838817 0.055306103612876 no 201 0.0631841661000228 403 4216 Selective myosin light chain kinase inhibitor.
SGTC_3048 9093155 49.47 µM 1.52309450275012 0.0559556960125719 no 202 0.0638675319930522 330 25236002
SGTC_2804 7954240 19.48 µM 1.51943749492809 0.0563920067752151 no 203 0.0643262050383371 447 828705
SGTC_1688 st021091 57.6 µM 1.51480039725222 0.0569491009330108 no 204 0.0649114799277685 377 3656366
SGTC_804 1595-0054 20.9 µM 1.51001434987275 0.0575286249072495 no 205 0.0655198813096456 395 761523 Stimulates phospholipase C.
SGTC_2823 7987624 58.44 µM 1.50770067290587 0.0578104374091917 no 206 0.0658155766164547 456 2239440
SGTC_229 benomyl 22.8748 µM 1.50449543103213 0.0582026369776088 no 207 0.0662269244524172 444 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2386 9075165 157.42 µM 1.4999046236131 0.0587680145356496 no 208 0.0668195550728286 382 16452277
SGTC_1749 st037932 54.2 µM 1.4981089586272 0.0589903275591825 no 209 0.0670524719529911 413 594497
SGTC_284 0988-0104 32.6 µM 1.49730507127317 0.0590900667127955 no 210 0.0671569479656778 439 4666532
SGTC_261 5-fluorouridine 15.376 µM 1.4925840571787 0.0596784797679744 no 211 0.067773049571555 422 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1470 k295-0292 231 µM 1.49083189772925 0.0598980282373741 no 212 0.0680028174455594 441 5045612
SGTC_929 2805-0021 398 µM 1.48864900795824 0.0601724323571333 no 213 0.0682899096004699 409 3098024
SGTC_3019 9081971 49.47 µM 1.48710619344206 0.0603669675344746 no 214 0.0684933830129441 428 16451803
SGTC_32 0928-0142 34.1 µM 1.47944124989541 0.0613407547587483 no 215 0.069511211155445 376 2244242
SGTC_2653 dihydrofissinolide 100 µM 1.47834185156923 0.0614814277505588 no 216 0.0696581504809793 379 6857746
SGTC_2703 st077852 53.4 µM 1.47741469277073 0.0616002576556594 no 217 0.0697822550203783 428 6281836
SGTC_2490 carminic acid 95.39 µM 1.47553210570389 0.0618420923659015 no 218 0.0700347716233668 349 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2316 5844804 197.44 µM 1.47378293327916 0.0620674523485709 no 219 0.070270022445118 548 776813
SGTC_1312 1218-2183 165 µM 1.47266962639218 0.0622112220153884 no 220 0.0704200702187466 441 6744073
SGTC_2224 6650123 117.647 µM 1.47088419015032 0.0624423309719425 no 221 0.0706612194709092 379 2908370
SGTC_1516 st013856 110 µM 1.46904347312462 0.0626812958105003 no 222 0.0709104990963422 403 5281404 A mutagen and neurotoxin.
SGTC_3062 9077494 49.47 µM 1.46792720048499 0.0628265589269418 no 223 0.0710619993574569 427 16459633
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.46481673259462 0.0632327151837295 no 224 0.0714854627200206 428 97141
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.46444148923746 0.0632818513007973 no 225 0.0715366794904139 427 140250 A respiratory chain inhibitor.
SGTC_2206 7254556 146.969 µM 1.45126979234886 0.0650255207796376 no 226 0.0733523746808733 365 4398905
SGTC_431 k089-0097 107 µM 1.45096958650142 0.0650656923538711 no 227 0.0733941646230138 532 5499420
SGTC_2099 5377090 177.372 µM 1.45036898998732 0.0651461180427031 no 228 0.0734778248887981 470 2243829
SGTC_2962 9082311 13.18 µM 1.44720846579348 0.0655706145458943 no 229 0.0739192731003869 420 16459453
SGTC_231 b-estradiol 524 µM 1.44263423754782 0.0661887830575639 no 230 0.0745617666857845 377 450 A steroid.
SGTC_1009 4106-0057 9.87 µM 1.44260951488696 0.066192136339557 no 231 0.0745652507615126 474 2928005
SGTC_1784 st039334 36.3 µM 1.44006228795649 0.0665383376577245 no 232 0.0749248886773232 452 3496984
SGTC_2074 5212007 75.395 µM 1.43091540008772 0.0677930811911414 no 233 0.076227231418653 385 758611
SGTC_1311 1190-0148 100 µM 1.43063329457601 0.0678320681422918 no 234 0.0762676700281707 562 1961333
SGTC_3191 9110352 49.47 µM 1.42246039711277 0.0689690956425291 no 235 0.0774463202317247 418 17122424
SGTC_912 3474-0017 2.18 µM 1.42120201869509 0.0691454609551393 no 236 0.0776290190039716 478 3360550
SGTC_1230 0170-0365 3.77 µM 1.42109474173876 0.069160512186503 no 237 0.0776446092267889 621 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_510 ag-490 170 µM 1.4207658849606 0.0692066673647348 no 238 0.0776924157607985 478 5328779
SGTC_827 3253-0474 693 µM 1.42066317301578 0.0692210878892315 no 239 0.0777073517696501 497 5402065
SGTC_2121 5257820 149.641 µM 1.4200880277388 0.0693018797637432 no 240 0.0777910276461634 488 791256
SGTC_263 alizarin 107.927 µM 1.4153782076926 0.069966213624919 no 241 0.0784788178005618 554 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3209 9113616 49.47 µM 1.41400459686419 0.0701608854940426 no 242 0.0786802763915453 509 16649353
SGTC_280 3448-3607 3.04 µM 1.40498005682227 0.07145024362177 no 243 0.0800136043526676 456 626179
SGTC_3070 9117005 49.47 µM 1.40270644132168 0.0717779309226883 no 244 0.0803521978675807 382 8779016
SGTC_470 aa-861 153 µM 1.39998516176736 0.0721716523390528 no 245 0.0807588809478156 522 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2228 7354201 200 µM 1.39870115201423 0.0723579998625697 no 246 0.080951309317196 438 753451
SGTC_2492 derrusnin 100 µM 1.39837589719738 0.0724052623605588 no 247 0.0810001085892379 416 1715307 Part of coumarin class of compounds.
SGTC_3141 9094609 49.47 µM 1.39460621295879 0.072954758904292 no 248 0.0815673102575588 465 25236309 YDL196W YDL196W
SGTC_1941 st076221 61.8 µM 1.39060266301888 0.0735418346292859 no 249 0.0821729741899817 560 2828568
SGTC_2098 5376439 882.5 nM 1.38331141906308 0.0746202845682723 no 250 0.0832846990820818 520 2844116
SGTC_2135 5326629 150.42 µM 1.38316251706829 0.0746424337982509 no 251 0.083307519999572 468 5020077
SGTC_2811 7967822 32.47 µM 1.38287149350077 0.0746857381537954 no 252 0.0833521362299878 514 2232244
SGTC_999 SEC7.066 22.7 µM 1.381905590864 0.0748296020463581 no 253 0.0835003455354027 528 740511 YDR170C SEC7
SGTC_413 propylparaben 100 µM 1.38078375806647 0.0749969558204436 no 254 0.083672729443393 478 7175 A pharmaceutical preservative.
SGTC_2723 salbutamol 83.58 µM 1.37993896731647 0.0751231690807855 no 255 0.0838027186877696 377 9884233 β2-adrenoceptor agonist
SGTC_917 harmaline 728.087 nM 1.37749886951337 0.0754886336593635 no 256 0.0841790320336415 513 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2281 7943571 200 µM 1.37544796886288 0.075796853050579 no 257 0.0844963030672167 514 1244024
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.37266793835171 0.0762161786627158 no 258 0.0849278003894093 453 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2453 5731132 22.18 µM 1.37254256660134 0.0762351306210817 no 259 0.084947298590401 524 1362040
SGTC_678 1218-2179 85.9 µM 1.37073542939069 0.0765087070936284 no 260 0.0852287230429259 433 6820081 YOR116C RPO31
SGTC_2810 7959871 45.46 µM 1.3705389739739 0.0765384927732621 no 261 0.0852593589825683 569 2974535
SGTC_1239 0337-0584 35.4 µM 1.36701204448803 0.0770747315974933 no 262 0.0858107651367787 566 914301 YML130C ERO1
SGTC_2177 5811945 192 µM 1.3667114870995 0.0771205604139099 no 263 0.0858578779326748 495 5343475
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.35792532601468 0.078469437886562 no 264 0.0872436901123197 506 688669
SGTC_719 2810-4230 27.3 µM 1.35376319638196 0.0791146301344188 no 265 0.0879059694285469 445 721079
SGTC_1889 st059080 5.18 µM 1.35345546771791 0.079162491690016 no 266 0.0879550837559158 541 176925 Isolated from Daphnopsis sellowiana.
SGTC_2079 5212404 121 µM 1.35254718971024 0.0793038855470912 no 267 0.0881001667142388 487 758462
SGTC_1011 4112-3381 17.4 µM 1.351762234491 0.0794262353787787 no 268 0.0882256944800878 521 2877139
SGTC_1244 0416-0015 52.5 µM 1.34719190677205 0.0801414447758613 no 269 0.0889592169211271 495 96201
SGTC_2372 9071633 200 µM 1.34617033188868 0.0803019744294322 no 270 0.0891237953458164 553 21321366
SGTC_2214 7179297 48.276 µM 1.34602734573098 0.0803244625593189 no 271 0.089146848860803 474 769744
SGTC_2465 5809242 33.21 µM 1.33812063260066 0.0815754107290606 no 272 0.0904285579579466 473 2731748
SGTC_2383 9036125 200 µM 1.3359060673451 0.0819284045140352 no 273 0.090789988783395 469 79580
SGTC_1109 tnp00067 928.257 nM 1.33351509011396 0.0823108086598321 no 274 0.0911814133946827 532 676295
SGTC_1241 0364-0022 50.8 µM 1.32706245777142 0.0833495262764498 no 275 0.0922440113955639 555 4563895
SGTC_3264 9137442 49.47 µM 1.3259234883806 0.0835338914542518 no 276 0.092432520969064 490 17015726
SGTC_1352 1496-0991 99 µM 1.32284235995925 0.084034169931372 no 277 0.0929439034880252 518 3000039
SGTC_1263 0774-1208 64.8 µM 1.32246142753924 0.084096177313979 no 278 0.0930072727831055 622 906585
SGTC_2991 9074669 71.4286 µM 1.31943105709985 0.0845906786997344 no 279 0.0935125223062705 604 17333109
SGTC_2662 daunorubicin 22.37 µM 1.31783584582485 0.0848518628820269 no 280 0.093779302726189 480 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2876 9059903 25.97 µM 1.31778920466249 0.0848595085338787 no 281 0.0937871113598765 554 6916095
SGTC_376 3970-0862 59.1 µM 1.31688732112846 0.0850074513527324 no 282 0.0939381985116383 547 3135186
SGTC_3104 9120930 49.47 µM 1.31597941208518 0.0851565777621774 no 283 0.0940904764341089 461 17014836
SGTC_2721 ifenprodil 61.44 µM 1.31529916954921 0.0852684377588237 no 284 0.0942046885647358 535 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_397 arbidol 50 µM 1.31265856983022 0.0857037047404352 no 285 0.0946490120108732 561 131410 A RNA synthesis inhibitor.
SGTC_2998 9066762 71.4286 µM 1.30925011732767 0.086267998355155 no 286 0.0952248203293421 600 4945196
SGTC_2586 curcumin 80 µM 1.30653541094587 0.0867194217336907 no 287 0.0956852725171463 631 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2719 novobiocin 32.65 µM 1.30291486398321 0.0873242197271325 no 288 0.0963019143738862 446 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3196 9111891 49.47 µM 1.30237720029223 0.0874143021882144 no 289 0.0963937363249752 505 18891510
SGTC_1089 terbinafine 2.25 µM 1.301325374403 0.0875907301159695 no 290 0.0965735526631846 530 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2925 9010536 32.5 µM 1.29913750479288 0.0879585631726416 no 291 0.0969483720500272 614 2994177
SGTC_1170 0310-0127 64.8 µM 1.29860917800771 0.0880475599241829 no 292 0.0970390433156255 556 774975
SGTC_324 1315-0088 19.6 µM 1.29815074536583 0.0881248373820526 no 293 0.0971177697968122 464 6787421
SGTC_2673 kobusone 100 µM 1.29359810073178 0.0888950176071004 no 294 0.0979021394256685 516 6710676 An epoxy ketone and protein crosslinker.
SGTC_2790 5423970 71.43 µM 1.29163820008093 0.0892281167791692 no 295 0.0982412342531627 596 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_991 3996-0057 64.7 µM 1.28984757187729 0.0895332579418834 no 296 0.0985517935160547 542 715343
SGTC_3028 9087778 49.47 µM 1.28704069117794 0.0900131394468126 no 297 0.0990400528163452 518 17217395
SGTC_2769 toremifene 3.73 µM 1.28416836425751 0.0905061859019603 no 298 0.0995415259050077 521 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2247 cerulenin 830 nM 1.2811897072426 0.091019599138031 no 299 0.100063520254316 555 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_774 k060-0086 136 µM 1.27872305240912 0.0914463942917145 no 300 0.100497299456866 630 5911235
SGTC_2023 5144124 124 µM 1.27799395906767 0.0915728298948768 no 301 0.10062577814127 557 2830192
SGTC_3302 9125395 16.351 µM 1.27081125269115 0.0928253487542123 no 302 0.101897902278283 549 17599668
SGTC_2159 5658611 73.75 µM 1.26626852095652 0.0936240221755834 no 303 0.102708481501194 544 793844
SGTC_906 1165-0455 526 µM 1.26263766332714 0.0942660155820695 no 304 0.103359712974988 557 3252859
SGTC_647 0140-0236 81 µM 1.25950142870235 0.0948231604571002 no 305 0.10392463725474 650 990837
SGTC_3109 9122853 49.47 µM 1.25638915327853 0.0953784439965672 no 306 0.104487456156265 593 1234709
SGTC_1698 5-fluorocytosine 1.055 µM 1.2557348092876 0.0954954941683999 no 307 0.104606067107502 558 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_930 2810-3379 265 µM 1.25129028404675 0.0962933374314086 no 308 0.105414294479136 651 1015764
SGTC_1763 st044482 94.5 µM 1.2454333753592 0.0973521870776047 no 309 0.106486245714991 600 88505
SGTC_1990 st072050 59.8 µM 1.24509465588525 0.0974136832140181 no 310 0.106548479155838 595 17233948
SGTC_2271 7849410 118.62 µM 1.24449764114938 0.0975221434539826 no 311 0.106658233490348 577 972430
SGTC_2812 7970281 58.44 µM 1.24263270489889 0.0978615186125327 no 312 0.107001606217638 588 2233435
SGTC_2303 7774051 200 µM 1.23612130556624 0.0990532293167496 no 313 0.108206738233423 571 2953184
SGTC_1458 k015-0034 6.33 µM 1.23558302137394 0.0991522185955485 no 314 0.10830679951833 555 3598957
SGTC_1364 1653-0028 37.6 µM 1.232364383782 0.0997456288971993 no 315 0.108906499550609 615 5718652
SGTC_1981 st071826 47 µM 1.2320150453907 0.0998101910942754 no 316 0.108971731983228 544 11838600
SGTC_1634 st006576 41 µM 1.22940548934604 0.100293436304619 no 317 0.10945990657883 586 3915356
SGTC_2546 rhodinyl acetate 100 µM 1.22928856139633 0.100315129266481 no 318 0.109481817218386 614 6708682
SGTC_2681 menadione 3.18 µM 1.2289408599506 0.100379656523192 no 319 0.109546990147193 589 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_984 1492-0255 2.91 µM 1.22558849824363 0.101003350142378 no 320 0.110176784140479 560 1585198
SGTC_2319 6033012 152.6 µM 1.22254498680615 0.101572025626078 no 321 0.110750801230817 537 847246
SGTC_1630 st005209 31.3 µM 1.21842895228978 0.102344804340751 no 322 0.111530504227588 681 3367314
SGTC_777 1315-0167 517 µM 1.2178545840904 0.102452980081087 no 323 0.111639618689741 578 4221767
SGTC_944 3370-0224 231 µM 1.21652437301516 0.102703829436777 no 324 0.111892616112199 603 4580514
SGTC_2616 abietic acid 100 µM 1.21610324352105 0.102783338405281 no 325 0.111972797563179 639 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2718 lomofungin 53.02 µM 1.21393784741094 0.103192870101023 no 326 0.112385729460315 580 5351222 A RNA synthesis inhibitor.
SGTC_2957 9076800 11.52 µM 1.21372373245375 0.103233428990689 no 327 0.112426619312863 544 16459615
SGTC_189 3970-0742 2.116 µM 1.2132025856621 0.103332195991037 no 328 0.112526187907982 592 2891807
SGTC_2872 9044037 25.97 µM 1.21227999568803 0.103507212121115 no 329 0.112702609346276 541 6465195
SGTC_2482 5981709 142.65 µM 1.21149530981511 0.103656236943695 no 330 0.112852815560757 638 877755
SGTC_744 1594-0068 283 µM 1.2106309783421 0.103820567896333 no 331 0.113018433051432 674 668392
SGTC_1829 berberine 14.4 µM 1.20883939855187 0.10416179350055 no 332 0.113362275993608 590 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2762 leflunomide 42.06 µM 1.20599937808531 0.104704370557289 no 333 0.11390886511375 646 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_940 3232-1287 54.8 µM 1.20271720986005 0.105333964806106 no 334 0.11454288590403 633 1585493 YIL048W NEO1
SGTC_2871 9038510 12.99 µM 1.20076440688967 0.105709853752578 no 335 0.114921301136868 666 4945164
SGTC_311 1315-0136 58 µM 1.1990564057893 0.106039415766092 no 336 0.115253006809407 639 6759207
SGTC_1996 st072960 66.8 µM 1.19664958554358 0.106505075408857 no 337 0.115721582396574 667 1719405
SGTC_1028 k015-0029 4.8 µM 1.19612566111106 0.106606637075697 no 338 0.115823762529039 646 4588309
SGTC_172 1112-0046 2.638 µM 1.19233545170775 0.107343443957807 no 339 0.116564869488068 554 2802135 YIL048W NEO1
SGTC_1831 st055328 12 µM 1.18735397102677 0.108317404248476 no 340 0.117544013888347 652 1103068
SGTC_2284 7945075 39.21 µM 1.1870859209662 0.108369992108875 no 341 0.117596865574914 699 1245402
SGTC_3324 9138759 60.749 µM 1.18669901340615 0.108445930625138 no 342 0.11767318216955 621 45595710
SGTC_3311 9131146 2.8755 µM 1.17952300056769 0.109861315535755 no 343 0.119094991747408 653 4900406 YPR165W RHO1
SGTC_936 3005-4620 401 µM 1.17747850775282 0.110266983928495 no 344 0.119502285447143 715 777207
SGTC_2875 9039966 71.43 µM 1.1771536992335 0.110331531221597 no 345 0.119567082537607 588 6463691
SGTC_636 0kpi-0074 126 µM 1.17385357841963 0.110988881425792 no 346 0.120226839543708 613 616434
SGTC_305 1682-2595 20.8 µM 1.17098521944452 0.11156250381594 no 347 0.12080235917037 663 226033
SGTC_1431 4049-0260 9.09 µM 1.16909663043232 0.111941345397876 no 348 0.121182350681549 652 3854841
SGTC_760 0568-0725 82.9 µM 1.16337589025861 0.113094508449451 no 349 0.12233851354815 695 3916171
SGTC_1928 4'-methoxychalcone 40.3 µM 1.1632137232662 0.113127320497912 no 350 0.122371399997042 650 641818
SGTC_1711 st032263 62.8 µM 1.15939347478172 0.11390225590655 no 351 0.12314791766994 611 3958979
SGTC_2698 st077697 67.5 µM 1.15829459323002 0.114125862339598 no 352 0.123371918533453 611 3154499
SGTC_1163 k060-0048 49.9 µM 1.15805271099937 0.11417512381837 no 353 0.123421263181983 711 6809982
SGTC_479 n-linoleoylglycine 10 µM 1.15697165160335 0.114395476323441 no 354 0.123641971283303 616 6433346 An anti-infammatory.
SGTC_2006 4011487 200 µM 1.15616896923552 0.114559282939524 no 355 0.123806024868459 682 45595294
SGTC_689 0833-0039 98 µM 1.15117963318159 0.115581221216002 no 356 0.124829171139335 688 5374726
SGTC_1527 coumarin 137 µM 1.15085945457801 0.115647022084878 no 357 0.12489503022865 594 323 A hepatotoxic, DNA x-linker.
SGTC_1301 naphtanilide LB 4.81 µM 1.15022842352213 0.115776785072505 no 358 0.125024901127672 694 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_278 4092-0821 23.9 µM 1.1491640841261 0.115995886278644 no 359 0.125244163781607 660 877900
SGTC_2301 7769476 200 µM 1.14613107993612 0.116621864068724 no 360 0.125870459711726 614 977820
SGTC_775 4577-0580 57.3 µM 1.14589036783125 0.116671646733856 no 361 0.125920258607557 680 2006902
SGTC_553 k007-0256 45.7 µM 1.14455852426039 0.116947363138133 no 362 0.126196040795166 668 6287000
SGTC_1777 st045864 34.765 µM 1.14384218666607 0.117095849181419 no 363 0.126344545375678 684 4691462
SGTC_2839 9003951 25.97 µM 1.14278573822486 0.11731507879086 no 364 0.126563780790739 635 2990634
SGTC_2618 avocadyne 43.43 µM 1.14227442946187 0.117421287703424 no 365 0.126669983287068 650 3015189
SGTC_747 3448-8087 38.7 µM 1.13931452927756 0.118037455306256 no 366 0.127285995247713 694 5168703
SGTC_1853 st056710 91.2 µM 1.13908860017887 0.118084581134988 no 367 0.127333100880801 684 269167
SGTC_3054 9094397 49.47 µM 1.13669557890313 0.118584550841454 no 368 0.127832784088043 695 2598354
SGTC_1266 0828-0227 32.9 µM 1.13621684566513 0.118684751028016 no 369 0.127932911013549 625 3913820
SGTC_214 4373-3496 70 µM 1.13560283165807 0.118813353393102 no 370 0.128061411620961 845 3779166
SGTC_2232 chlorophetanol 41.5365 µM 1.13435482408825 0.119075046020301 no 371 0.128322870397848 808 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1112 tnp00069 1.16933 µM 1.1321241919822 0.11954379670413 no 372 0.128791112705981 740 145826
SGTC_3313 9133968 57.047 µM 1.1319637035544 0.119577572275579 no 373 0.128824847222974 715 1494643
SGTC_2854 9024559 71.43 µM 1.13100288898198 0.119779921166792 no 374 0.129026937737819 631 3163529
SGTC_2641 levomentholum 100 µM 1.13028614528238 0.119931025544475 no 375 0.129177835309768 643 16666
SGTC_1206 3978-0017 132 µM 1.12665330383119 0.120698970082587 no 376 0.129944546393994 637 3873677
SGTC_2909 7941780 10.49 µM 1.12521801365684 0.121003327308212 no 377 0.130248330799016 706 1243215
SGTC_1641 st009299 47.1 µM 1.1241070605823 0.121239278405258 no 378 0.130483805179746 609 4046054
SGTC_1558 st069300 45.6 µM 1.12326081205762 0.121419226892234 no 379 0.130663370988104 616 24208000
SGTC_2270 7924575 90.91 µM 1.12263976801057 0.121551406726805 no 380 0.130795259215626 708 1262135
SGTC_2389 9091542 195.52 µM 1.12247570268315 0.121586342433469 no 381 0.130830116363457 713 3626624 YOL127W RPL25
SGTC_1810 st050138 53 µM 1.12133039972441 0.121830417295034 no 382 0.131073625077027 648 3444541
SGTC_1486 3970-0793 4.53 µM 1.12035716203251 0.122038093787874 no 383 0.13128079605365 688 2844330
SGTC_701 4424-0219 185 µM 1.11895850866419 0.122336983723804 no 384 0.13157892014873 761 2911779
SGTC_270 tamoxifen 5.46 µM 1.11791010709089 0.122561362080166 no 385 0.13180269396656 755 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2081 5214970 32.255 µM 1.11763654433559 0.122619957307783 no 386 0.131861127148473 674 2063512
SGTC_2768 sulfasalazine 50.2 µM 1.11549806031451 0.123078682935114 no 387 0.132318524595055 688 5384001 An antioxidant and salicylic acid derivative.
SGTC_703 3875-0075 71.8 µM 1.11457256391783 0.123277583404835 no 388 0.132516816426246 743 2850814
SGTC_2160 5660466 132.927 µM 1.11178969885917 0.123877011476448 no 389 0.133114290983534 663 2859134
SGTC_894 0960-0238 55.9 µM 1.10735887257139 0.124835614338323 no 390 0.134069399987945 705 6741907 YDL195W SEC31
SGTC_2942 9052777 62.25 µM 1.10482435210668 0.125386278757276 no 391 0.134617853176443 764 6469503
SGTC_128 0906-2981 13.371 µM 1.10304921292169 0.125772963877781 no 392 0.13500289709368 645 6740226
SGTC_1308 1187-1617 41.4 µM 1.10115220655678 0.126187114387898 no 393 0.135415209296803 734 2882570
SGTC_1741 st038134 10.228 µM 1.0972812558345 0.127035158781453 no 394 0.136259231082151 748 1272587
SGTC_2583 asiatic acid 100 µM 1.09496867898887 0.127543684538049 no 395 0.13676517925507 687 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1257 0669-0121 16 µM 1.09347965943705 0.127871861669299 no 396 0.137091627487211 773 4307855
SGTC_2980 9014342 25.29 µM 1.09127806809641 0.128358162691665 no 397 0.137575272614326 676 2996599
SGTC_707 0865-0008 204 µM 1.08936248301424 0.128782332289965 no 398 0.13799703442496 742 723043
SGTC_2458 5808907 16.39 µM 1.08929836866071 0.128796545982825 no 399 0.13801116596726 784 2731747
SGTC_1524 corynanthine 62.1 µM 1.08858696551928 0.128954331995668 no 400 0.138168033652359 686 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1811 st050069 61.5 µM 1.08830782038678 0.129016281735268 no 401 0.138229619644139 696 3877702
SGTC_2832 7992762 51.95 µM 1.08644832157732 0.129429480661262 no 402 0.138640346427006 616 2985177
SGTC_283 0987-0079 11.7 µM 1.08548699040407 0.129643457093985 no 403 0.138853011300235 753 411556
SGTC_2408 sulbentine 18.36 µM 1.08431976288213 0.129903591854152 no 404 0.139111522853105 704 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1953 st076800 12.1 µM 1.08397441037976 0.129980628246658 no 405 0.139188072511252 719 297591
SGTC_2704 st078022 71.1 µM 1.08242139312569 0.130327444378816 no 406 0.139532663292009 734 54697681
SGTC_1321 1326-2144 215 µM 1.08017716110278 0.130829751040886 no 407 0.140031648322995 711 3513030
SGTC_543 3844-1095 191 µM 1.07911149432955 0.13106873777065 no 408 0.140269013906206 778 4230703
SGTC_2877 9040724 71.43 µM 1.07739993919326 0.131453202457123 no 409 0.140650815644404 735 6463895
SGTC_2720 fluspirilene 36.88 µM 1.07571777826091 0.131831822277061 no 410 0.141026746981461 647 3396 An atypical antipsychotic.
SGTC_448 monastrol 171 µM 1.07558264372376 0.131862270894572 no 411 0.141056976552911 720 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_592 k241-0073 46.5 µM 1.07547353273316 0.131886859406295 no 412 0.141081387868029 770 4230158
SGTC_3340 9146634 11.102 µM 1.07522707374607 0.13194241136962 no 413 0.141136538484764 730 4907387
SGTC_3322 9139058 2.11 µM 1.07350827151653 0.132330278889026 no 414 0.141521564724391 749 4908926 YPR165W RHO1
SGTC_213 1246-0773 967 nM 1.07301868690371 0.13244090295712 no 415 0.141631365931536 762 6251622
SGTC_367 0335-0881 7.1 µM 1.07108852389831 0.132877653630211 no 416 0.142064813899231 752 23828853
SGTC_319 1348-1596 45.5 µM 1.07083329899125 0.132935479198595 no 417 0.142122195744868 774 5380505
SGTC_816 0325-0417 81.3 µM 1.07049588074904 0.133011953662371 no 418 0.142198081073809 714 68101
SGTC_507 nimesulide 162 µM 1.06756864028461 0.13367667176683 no 419 0.142857567881189 749 4495 A COX2 inhibitor.
SGTC_2299 7976368 114.88 µM 1.06726036267267 0.133746808179716 no 420 0.142927140795044 731 2979718
SGTC_2305 7443522 69.23 µM 1.06390335740509 0.134512200069804 no 421 0.143686240966047 787 5415886
SGTC_2905 7799065 20.05 µM 1.06320620866395 0.134671525189242 no 422 0.143844223719405 705 1296806
SGTC_1046 2001-0062 216 µM 1.0614376252572 0.135076294917106 no 423 0.144245532728131 734 739778
SGTC_3156 9099931 49.47 µM 1.06085236654392 0.135210424641089 no 424 0.144378499746042 776 18111053
SGTC_1465 k213-0056 144 µM 1.06070820816114 0.13524347690315 no 425 0.144411264279502 721 24048857 YMR208W ERG12
SGTC_2356 9061756 188.97 µM 1.06057474994653 0.135274080795465 no 426 0.144441601329053 730 20104043
SGTC_1427 4048-4900 550 nM 1.05870885024221 0.135702455694818 no 427 0.144866198014651 752 24132586
SGTC_1185 1319-0113 81.3 µM 1.05652611501168 0.136204748082817 no 428 0.145363958089127 692 4672763
SGTC_2105 5350118 200 µM 1.05558692112551 0.136421266982865 no 429 0.145578489405715 748 2133313
SGTC_2793 7325131 81.82 µM 1.05556337188727 0.136426698976678 no 430 0.145583871273549 716 4176441
SGTC_521 r062-0005 13.8 µM 1.05356975855741 0.136887093043944 no 431 0.146039970405272 728 2832033
SGTC_1036 k216-0215 33.5 µM 1.05263734603315 0.137102783299628 no 432 0.146253617008709 754 622330
SGTC_1233 0325-0408 14.2 µM 1.05254898640174 0.137123235122202 no 433 0.146273874010214 746 12874
SGTC_170 4197-0004 226 µM 1.04767894038702 0.138253685587108 no 434 0.147393276762204 688 218692
SGTC_1300 1094-0077 113 µM 1.04742168784275 0.138313576018796 no 435 0.14745256665809 712 5532636
SGTC_3197 9113331 49.47 µM 1.04237940887622 0.13949102946978 no 436 0.148617904620996 755 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2076 5212012 200 µM 1.04204105779383 0.139570283269445 no 437 0.14869632191138 667 604802
SGTC_499 genistein 192 µM 1.04053192509275 0.139924148415801 no 438 0.149046419902811 741 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_298 1391-0729 10 µM 1.04035495463129 0.139965684792793 no 439 0.149087510652401 745 3237558
SGTC_2343 7990716 14.84 µM 1.04017718094962 0.14000741812731 no 440 0.14912879551918 779 6456862
SGTC_2264 7948757 110.76 µM 1.03855087771126 0.140389594105004 no 441 0.149506830770634 722 2971411
SGTC_1177 0983-0204 23.6 µM 1.03737804666639 0.140665644823606 no 442 0.149779852711207 811 766818
SGTC_904 1141-0088 396 µM 1.03570455418201 0.141060174305834 no 443 0.150169998533058 735 1378119
SGTC_2179 6298986 200 µM 1.02894191931087 0.142662118675526 no 444 0.151753484218853 753 738374
SGTC_3025 9087895 49.47 µM 1.02886924085565 0.142679401412904 no 445 0.151770562082635 837 17173641
SGTC_1491 4138-0063 26.5 µM 1.02836199722366 0.142800061973658 no 446 0.151889788916569 749 23883227
SGTC_2031 5180455 200 µM 1.02561548095989 0.143454587050268 no 447 0.152536433700336 733 29949
SGTC_2124 5246320 200 µM 1.01890792707124 0.145061573096045 no 448 0.154123339992764 760 579342
SGTC_209 4077-0173 175.592 µM 1.01459023845464 0.146102384704371 no 449 0.155150597216637 665 15993494
SGTC_2693 st077581 40.7 µM 1.01454239699177 0.146113945281935 no 450 0.155162004838856 874 25238761
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.01349810103489 0.146366445688198 no 451 0.155411151356391 739 15053
SGTC_108 0509-0257 621.132 µM 1.01338017913474 0.146394976432121 no 452 0.155439301559329 811 536624
SGTC_215 1287-0124 461.5 µM 1.01286456726981 0.146519770565811 no 453 0.155562427443214 772 5560863
SGTC_1278 0874-0585 172 µM 1.01262176350138 0.146578561363864 no 454 0.155620430208522 797 766306
SGTC_591 4299-0174 154 µM 1.01181456854852 0.146774123669981 no 455 0.155813361452383 786 5509088
SGTC_1632 st005650 90 µM 1.00855319389638 0.14756605156277 no 456 0.156594482241034 768 2759605
SGTC_2306 7482397 179.52 µM 1.0069856698672 0.147947694796753 no 457 0.156970830319774 789 891448
SGTC_2141 5621638 7.665 µM 1.00573018375567 0.148253842631897 no 458 0.157272689749835 799 2856238
SGTC_1027 k015-0025 8.67 µM 1.00550981697548 0.14830762233345 no 459 0.15732571239105 780 3598955
SGTC_514 4466-0038 2.65 nM 1.00404324406166 0.148665866455729 no 460 0.157678885078297 845 5722064
SGTC_2097 5376186 200 µM 1.00147532323159 0.149294532247561 no 461 0.158298532234269 803 742755
SGTC_2587 piperic acid 92.2 µM 0.999083335695034 0.149881721409425 no 462 0.158877161518244 727 5370536
SGTC_1913 st060213 96.1 µM 0.998050824515137 0.150135659289852 no 463 0.159127356993334 834 688959
SGTC_1555 citronellol 128 µM 0.996628412763251 0.150485959539254 no 464 0.159472454648569 773 8842 A terpine precursor.
SGTC_152 4469-0003 551.229 µM 0.994659723291101 0.150971690309244 no 465 0.159950894867172 803 697280
SGTC_2338 7999974 200 µM 0.993036766188166 0.151372903041195 no 466 0.160346018786337 871 315925
SGTC_2795 7780010 54.55 µM 0.993027571279486 0.151375178141252 no 467 0.160348259187519 759 953673
SGTC_879 0831-1030 162 µM 0.988590212500715 0.152475769330443 no 468 0.161431838404512 833 1549252
SGTC_758 0868-0029 16 µM 0.987067247799243 0.152854728874922 no 469 0.161804836323332 828 762687
SGTC_1134 3477-0009 42.5 µM 0.982486803743563 0.153998242531658 no 470 0.162930040482438 859 3973534
SGTC_1430 4049-0248 69.1 µM 0.981897297658685 0.154145823532598 no 471 0.163075223610262 912 22774488
SGTC_471 1-acyl-paf 4 µM 0.977269973787579 0.155307507941031 no 472 0.164217757018198 803 16759367
SGTC_1922 5578187 25 µM 0.974519439363204 0.156000757449579 no 473 0.164899345938895 781 1350412
SGTC_3189 9110682 49.47 µM 0.973724816996672 0.156201414599574 no 474 0.165096595847483 809 17122418
SGTC_847 0342-0274 5.54 µM 0.972171843238904 0.156594060482226 no 475 0.165482532853821 871 18097
SGTC_3103 9120822 49.47 µM 0.972114044605435 0.156608686521641 no 476 0.165496907926579 868 17141819
SGTC_1520 flindersine 88 µM 0.971652634445244 0.156725479367636 no 477 0.165611694006252 851 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1387 3342-1166 1.8 µM 0.96964154094579 0.157235199710037 no 478 0.16611259950364 762 3418228
SGTC_2593 nobiletin 86.24 µM 0.969444246289219 0.157285263539088 no 479 0.166161792589647 766 72344 An anti-infammatory.
SGTC_188 3229-0966 278.469 µM 0.968584203917942 0.157503623042003 no 480 0.166376343882574 955 5722370
SGTC_3288 9119690 36.221 µM 0.966972074142789 0.157913469393552 no 481 0.166778997073185 754 17595618 YKL019W RAM2
SGTC_2333 9017922 200 µM 0.966713010799195 0.157979395449422 no 482 0.166843760550146 839 3163164
SGTC_353 1988-1175 58.3 µM 0.966633060300622 0.1579997447822 no 483 0.166863750722355 780 2788357
SGTC_244 nsc-207895 1.295 µM 0.9665379876925 0.158023945296871 no 484 0.166887523914726 724 42640
SGTC_627 1391-0720 175 µM 0.965181058110276 0.158369613820813 no 485 0.167227066345338 809 997839
SGTC_960 1222-0186 7.7 µM 0.96487220670432 0.158448360853898 no 486 0.16730441193367 850 3126296
SGTC_1396 3511-0007 98.6 µM 0.961743247569813 0.159247591273776 no 487 0.168089296166002 749 X1396
SGTC_1411 3909-8223 150 µM 0.960790651697398 0.159491436307883 no 488 0.168328719952043 904 X1411
SGTC_1813 st051246 8.6015 µM 0.960314145477138 0.1596135038032 no 489 0.168448566455714 834 5291959
SGTC_3147 9097027 49.47 µM 0.959176781628023 0.159905111512089 no 490 0.168734847567297 899 25236841
SGTC_1503 4585-0012 61.3 µM 0.957148090047553 0.160426110482952 no 491 0.169246256816435 832 2922052
SGTC_618 k072-0232 33.2 µM 0.955053804506513 0.160965117194095 no 492 0.169775244254005 818 5872756 YGL099W LSG1
SGTC_654 1124-0271 80.9 µM 0.954993137279684 0.160980748727276 no 493 0.169790583738401 855 5403748
SGTC_2545 solidagenone 89.61 µM 0.953086402573812 0.161472543372012 no 494 0.170273147466904 627 6708572 An anti ulcer agent
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.951898477334033 0.161779433823592 no 495 0.170574235926032 675 4000243
SGTC_1949 st076024 69.1 µM 0.950017249964833 0.162266210069501 no 496 0.171051743834601 849 2921930
SGTC_880 0833-0487 87.2 µM 0.949146948969486 0.162491726725492 no 497 0.171272939462783 826 76075
SGTC_155 k072-0202 43.6 µM 0.946150486551119 0.163269743931043 no 498 0.172035918121365 848 5857737
SGTC_626 0214-0009 33 µM 0.94422613822727 0.163770665996294 no 499 0.172527050466621 894 3437874
SGTC_849 0386-0493 241 µM 0.942965651863797 0.164099320026584 no 500 0.172849236067968 835 726119
SGTC_1499 4480-0877 67.3 µM 0.942790742233565 0.16414495902248 no 501 0.172893973978893 822 2861909
SGTC_996 3970-0799 1.8 µM 0.938658970482905 0.165225451936219 no 502 0.173952932679716 1053 6615648 YGL040C HEM2
SGTC_171 k064-0041 9.68 µM 0.938345296930362 0.165307667769988 no 503 0.174033494201825 785 53325
SGTC_1157 4092-0394 27.6 µM 0.938107106006339 0.165370116807194 no 504 0.174094685183341 927 3659885
SGTC_599 1935-0052 86.5 µM 0.936800834721091 0.165712867137428 no 505 0.17443050793482 893 9557311
SGTC_1727 st034309 9.9045 µM 0.935305091354303 0.166105896398451 no 506 0.174815546107042 942 870305
SGTC_536 3852-0578 10.6 µM 0.935013000987136 0.16618271780209 no 507 0.174890799686988 901 2869208
SGTC_1489 4065-0444 182 µM 0.932808567517992 0.166763236213854 no 508 0.175459408437811 859 2877968
SGTC_621 3584-0052 32.1 µM 0.931261336447101 0.167171466575068 no 509 0.17585919830792 911 2273927
SGTC_1268 0828-0275 2.46 µM 0.93097148731498 0.167248013629676 no 510 0.175934156695976 919 745337
SGTC_2818 7996756 12.99 µM 0.930439789365239 0.167388489928492 no 511 0.176071712617588 804 2241621
SGTC_2643 anethole 100 µM 0.927445296887296 0.168181063834254 no 512 0.176847690743178 921 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_659 k018-0002 107 µM 0.925164309395921 0.168786406559709 no 513 0.177440222743358 904 6797879 YHR007C ERG11
SGTC_438 sphingosine 6.67 µM 0.923008582223772 0.169359792135286 no 514 0.178001366396718 782 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3241 9133421 49.47 µM 0.922646442215678 0.169456237527688 no 515 0.178095742420646 901 17018221
SGTC_2437 5741531 144.16 µM 0.922323182468924 0.169542358066098 no 516 0.178180012639026 920 2262990
SGTC_1997 st073024 93.8 µM 0.922074823884315 0.169608543047082 no 517 0.17824477402778 891 686268
SGTC_83 0170-0301 39.027 µM 0.920777059259523 0.169954653367858 no 518 0.178583417252013 832 3089716
SGTC_1130 3454-2858 15.9 µM 0.920776357053794 0.169954840766707 no 519 0.178583600597635 839 715628 YIL048W NEO1
SGTC_1469 k284-2957 126 µM 0.91866126816226 0.170519899224381 no 520 0.179136387296417 891 23884841
SGTC_383 2324-0395 7.37 µM 0.918218638966493 0.170638302264618 no 521 0.179252206209942 906 3146421
SGTC_3115 9123671 49.47 µM 0.917363818413854 0.170867115173769 no 522 0.179476012893458 954 3286988
SGTC_2692 st077426 47.7 µM 0.916445573325318 0.17111312376889 no 523 0.17971662080523 919 25238571
SGTC_724 3910-0327 137 µM 0.912801208606524 0.172091723911809 no 524 0.180673551283703 900 2885483
SGTC_873 0591-4978 488 µM 0.91007926130961 0.172824958330418 no 525 0.181390355385999 963 3305145
SGTC_333 3486-0131 40.1 µM 0.908099534430503 0.173359503242773 no 526 0.181912818217864 955 6744690
SGTC_656 4090-1979 187 µM 0.905894834504409 0.173956030362915 no 527 0.182495759331361 964 22330961
SGTC_3055 9094636 49.47 µM 0.905594245364662 0.174037461951191 no 528 0.182575327906355 870 25236176
SGTC_335 4077-0256 27.6 µM 0.902121450996049 0.17498002173654 no 529 0.18349617749734 994 3121989
SGTC_51 1013-0126 23.419 µM 0.901660807120439 0.17510528910478 no 530 0.183618539379482 884 1627850
SGTC_37 0566-0070 1.56 µM 0.901202566531599 0.175229959351401 no 531 0.183740313306867 953 1626686
SGTC_1679 SEC14.276 6.7 µM 0.901028855054387 0.175277234503721 no 532 0.183786488949828 952 1005053 YMR079W SEC14
SGTC_3344 9148862 3.898 µM 0.900080905768069 0.175535359047394 no 533 0.184038598299026 933 4905352
SGTC_895 0964-0006 13.7 µM 0.899724116374876 0.175632574399984 no 534 0.184133543023416 909 6738897
SGTC_2981 9013952 38.96 µM 0.899649365121153 0.175652946394166 no 535 0.184153438836968 840 2996344
SGTC_2128 5255449 168.493 µM 0.899524136765018 0.175687078291735 no 536 0.1841867726479 958 736008
SGTC_3064 1327-0027 10 µM 0.899437752961624 0.17571062527338 no 537 0.184209768840869 776 16000455 YPR107C YTH1
SGTC_1391 3442-0225 151 µM 0.899335501580812 0.175738500112241 no 538 0.18423699144366 887 5227075
SGTC_2551 apiole 73.87 µM 0.897632932463665 0.176203050593 no 539 0.184690637886343 795 10659 A possible DNA adduct former.
SGTC_2838 9002687 71.43 µM 0.897249482954901 0.176307782939474 no 540 0.184792903047374 851 6457060
SGTC_3101 9120531 49.47 µM 0.896121034359732 0.176616226880974 no 541 0.185094062020005 925 24824904
SGTC_149 3970-0822 46.1 µM 0.89539968949442 0.176813573994142 no 542 0.185286733292946 1029 3114250 YBL034C STU1
SGTC_2635 hydroquinidine 100 µM 0.895360516794175 0.176824294936265 no 543 0.185297199888228 901 442912 An experimental heart treatment.
SGTC_2355 9061122 103.12 µM 0.89464100912262 0.177021285769511 no 544 0.185489511198815 919 5302957
SGTC_1453 4237-0541 195 µM 0.894461592620414 0.177070429013535 no 545 0.185537485255665 936 739892
SGTC_828 2074-0507 139 µM 0.893784701985619 0.177255910961214 no 546 0.185718547900905 933 X828
SGTC_1221 2958-7315 257 µM 0.891483109331899 0.177887512140455 no 547 0.18633502452058 878 4562705
SGTC_691 1548-0686 185 µM 0.887444086325974 0.178999323731308 no 548 0.187419928420328 917 46495133
SGTC_3253 9135987 49.47 µM 0.887001490462217 0.179121421232465 no 549 0.187539049018407 882 4182430
SGTC_2328 6201408 200 µM 0.881035501170606 0.180772349406654 no 550 0.189149302620547 867 2890418
SGTC_2064 5220758 200 µM 0.878150377348856 0.181574141288057 no 551 0.189931058577299 955 788518
SGTC_878 0828-0289 13.7 µM 0.875971121205202 0.182181241740102 no 552 0.1905228667331 929 745350 YLR208W SEC13
SGTC_468 gf-109203x 121 µM 0.875463633951186 0.182322800225217 no 553 0.190660844504719 842 2396 A protein kinase C inhibitor.
SGTC_382 3229-0966 23.2 µM 0.87480547783339 0.182506488617097 no 554 0.19083987808389 977 5722370
SGTC_2093 5331342 194.4 µM 0.873126376567651 0.182975641576954 no 555 0.191297099231965 963 33839
SGTC_2975 9084847 53.72 µM 0.872115848975443 0.183258352648722 no 556 0.191572590379409 932 27211724
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.87182051773638 0.183341027644143 no 557 0.191653149777775 904 5282362
SGTC_1280 0880-0253 10.1 µM 0.87072459304854 0.183648023904998 no 558 0.191952273499107 935 6836607
SGTC_1560 lithocholic acid 53.1 µM 0.868611787107698 0.184240777723359 no 559 0.192529752577511 899 9903 A bile acid which acts as a detergent.
SGTC_1055 3448-0672 86 µM 0.867506296646321 0.184551400198612 no 560 0.192832331630667 908 748378
SGTC_2622 2-methoxyxanthone 59.94 µM 0.865988850750068 0.184978304572792 no 561 0.193248137975132 986 71034 A hepatoprotective.
SGTC_2449 5812982 45.77 µM 0.86422949343062 0.185474033523678 no 562 0.19373091666831 901 776185
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.863211373933708 0.185761282369556 no 563 0.194010630635774 985 23847180
SGTC_966 1300-0360 30.2 µM 0.8626476859417 0.185920438045374 no 564 0.194165601739096 914 70588
SGTC_362 0310-0100 9.03 µM 0.861992745449977 0.186105464762837 no 565 0.194345754968674 932 790235
SGTC_99 0109-0120 622.8 µM 0.861181890472935 0.186334696824839 no 566 0.194568936241684 935 759414
SGTC_3107 9121808 49.47 µM 0.857645442589559 0.187336509085194 no 567 0.195544137126078 942 662681
SGTC_1125 tnp00248 1.32998 µM 0.855755227734146 0.187873335969377 no 568 0.196066592450538 1099 24207736
SGTC_36 0335-0881 14.2 µM 0.85472655897296 0.188165879821734 no 569 0.196351271881205 977 23828853
SGTC_2059 5238311 157 µM 0.854166210522599 0.188325355930334 no 570 0.196506451142644 925 703021
SGTC_1608 st001473 40.5 µM 0.851374438179917 0.189121140940908 no 571 0.19728069329776 922 7292267
SGTC_107 0358-0022 2.6945 µM 0.851213277695542 0.189167142312546 no 572 0.197325444195963 877 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_212 3807-4682 38.772 µM 0.850905892319599 0.189254900967476 no 573 0.197410815712375 1106 3125501 YBL034C STU1
SGTC_1328 1441-0025 69.2 µM 0.850839143778075 0.18927396101627 no 574 0.197429357034933 924 4562601
SGTC_1007 4101-0031 70 µM 0.850195131169001 0.189457919543878 no 575 0.197608304105448 993 1146276
SGTC_1552 6-methylflavone 10.6 µM 0.849711045818905 0.189596268171905 no 576 0.197742877881852 954 689013
SGTC_464 bw-b 70c 158 µM 0.848838839366819 0.189845696260647 no 577 0.197985487501195 1006 5353454
SGTC_1126 isoteolin 1.0172 µM 0.848035468035159 0.190075617736863 no 578 0.198209109181073 958 133323
SGTC_1078 idebenone 36.1 µM 0.847753489797116 0.190156359273023 no 579 0.198287635107254 997 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_840 0245-0196 390 µM 0.846938217784923 0.190389922462667 no 580 0.198514779470292 1009 3827528
SGTC_2478 5763493 32.33 µM 0.843437245406829 0.191394899803589 no 581 0.199491974449364 988 1365576 YLR208W SEC13
SGTC_2157 5649910 96.377 µM 0.842879460344218 0.191555315402517 no 582 0.19964793095444 950 2858091
SGTC_2091 4-phenylthiadiazole 200 µM 0.842135081808466 0.191769522409397 no 583 0.199856173169826 994 270010
SGTC_1751 st044839 27.194 µM 0.84059004105322 0.192214600883567 no 584 0.200288819898391 997 5291326
SGTC_1607 st000305 50.6 µM 0.839702239022953 0.192470634827208 no 585 0.200537679146518 982 5457690
SGTC_2964 9083345 53.42 µM 0.838621898821674 0.192782476092429 no 586 0.200840758976214 932 17741579
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.83824770052068 0.192890560736826 no 587 0.200945801040467 984 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_829 1635-0120 117 µM 0.837580923968496 0.193083246343056 no 588 0.201133055090188 1034 285054
SGTC_684 1140-0066 328 µM 0.836969429090427 0.193260059876607 no 589 0.201304876080457 1037 6813534
SGTC_530 4358-1714 28 µM 0.83687714489395 0.193286752399628 no 590 0.201330814210287 1012 1564641
SGTC_1993 st073995 70.8 µM 0.836019549916679 0.193534913010384 no 591 0.201571952472767 1000 3098394
SGTC_686 1319-0111 510 µM 0.835606269146904 0.193654572632871 no 592 0.201688220376908 1022 4562600
SGTC_3006 9075424 71.4286 µM 0.8353493933385 0.193728970132726 no 593 0.201760507253182 958 7465181
SGTC_2880 9042983 58.44 µM 0.834386722333191 0.194007938125273 no 594 0.202031548452501 962 6464714
SGTC_35 0133-0054 64.071 µM 0.832256068370897 0.194626240292931 no 595 0.202632211047653 953 99677
SGTC_787 4152-0075 138 µM 0.829757755725668 0.19535275992882 no 596 0.203337879832024 980 9566539
SGTC_1310 1188-0297 994 nM 0.829284618696441 0.195490535456394 no 597 0.203471686209766 988 1588352
SGTC_410 α-linolenic acid 100 µM 0.827977822693737 0.195871375468386 no 598 0.20384152981045 1017 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1320 1313-0481 95.3 µM 0.824950838064729 0.196755258187258 no 599 0.204699751059387 1050 6813365 YLR208W SEC13
SGTC_3102 9121669 49.47 µM 0.824090263860774 0.197006987084726 no 600 0.204944135908427 1007 41905072
SGTC_392 N-ethylmaleimide 8.33 µM 0.824062860196532 0.197015006206241 no 601 0.2049519208174 956 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3046 9092212 49.47 µM 0.820909001953784 0.197939237607527 no 602 0.205849051554388 985 25236637
SGTC_2611 pyromycin 23.93 µM 0.820828574681995 0.197962840839821 no 603 0.20587195991653 987 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3021 9087658 49.47 µM 0.819165130341408 0.198451397922005 no 604 0.206346103239743 1014 25237042
SGTC_329 k048-0121 21.3 µM 0.814572952173837 0.199803901383392 no 605 0.207658399032594 996 6832902
SGTC_2152 5568786 200 µM 0.81114983721522 0.200815686153252 no 606 0.208639814319143 1010 5399883
SGTC_5 0352-0601 109.883 µM 0.811024699106493 0.200852731924575 no 607 0.208675743441899 972 762456
SGTC_1146 3579-1023 7 µM 0.809856763141326 0.201198684334128 no 608 0.209011252077474 1076 X1146
SGTC_143 4032-1194 15.74 µM 0.80972460020236 0.20123785459371 no 609 0.209049238034518 1059 1806963
SGTC_712 r015-0009 80.6 µM 0.809373091229551 0.201342056560933 no 610 0.20915028769019 969 6813872 YLR060W FRS1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.80915949152809 0.201405392244885 no 611 0.209211706074581 964 61125 An anti-inflammatory.
SGTC_1817 st052116 64.4 µM 0.809007795234032 0.201450379841705 no 612 0.209255331221667 1010 4361398
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.808926021818909 0.201474633356726 no 613 0.209278850017625 976 5379071
SGTC_52 0329-0193 875 nM 0.808413051458611 0.201626817267454 no 614 0.209426420560696 986 3739292
SGTC_587 k089-0003 57 µM 0.808096197661097 0.201720853291276 no 615 0.209517603166878 960 9659696
SGTC_3268 9137683 49.47 µM 0.807608661138029 0.201865595907648 no 616 0.209657949601113 1008 1953228
SGTC_174 3553-0389 74.3 µM 0.807041208925211 0.202034142630882 no 617 0.209821370851629 982 738071
SGTC_2470 5664817 21.68 µM 0.804386392235942 0.202823804042405 no 618 0.210586928780852 1038 2859561
SGTC_603 3794-0023 45.9 µM 0.804000601846027 0.202938708632611 no 619 0.210698313713621 1031 3802260
SGTC_1605 st000082 49.1 µM 0.803574879225316 0.203065551832423 no 620 0.21082126793563 1037 1114022
SGTC_2754 granisetron 64.02 µM 0.803474010519723 0.20309561239588 no 621 0.210850406292928 1013 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_299 1273-0059 1.44 µM 0.802933788280507 0.203256652882698 no 622 0.211006502701413 1006 2848077
SGTC_3144 9087057 49.47 µM 0.802676903243469 0.203333257153489 no 623 0.211080753008412 990 17249618
SGTC_358 0075-0058 9.45 µM 0.801742767410687 0.203611965844324 no 624 0.211350885622792 1063 1069125
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.800582921079334 0.203958334352979 no 625 0.211686570648754 1022 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2165 5727197 32.143 µM 0.799989272368958 0.204135753266035 no 626 0.211858506300826 1037 1361712
SGTC_1559 coumarin 343 70.1 µM 0.799047192246703 0.204417493626143 no 627 0.212131524123613 1004 108770 A hepatotoxic, DNA x-linker.
SGTC_1208 2323-2347 50.3 µM 0.798007616867611 0.204728659586969 no 628 0.212433034991625 1054 5412760
SGTC_76 0433-0009 400.328 µM 0.797537856826902 0.204869360650337 no 629 0.212569362863404 929 2841569
SGTC_1620 st003704 16.5 µM 0.794999382564127 0.205630670853557 no 630 0.213306930656451 1043 2834414
SGTC_2211 7117706 200 µM 0.793321176409381 0.206134900081469 no 631 0.213795361008212 1011 822771
SGTC_1077 5-fluorocytosine 377 nM 0.792964232593613 0.206242240908826 no 632 0.213899330985815 1015 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1159 4092-0538 61.2 µM 0.792675327065871 0.206329145388164 no 633 0.213983504440364 1110 717301
SGTC_169 k015-0017 16.025 µM 0.792398501298141 0.206412436560883 no 634 0.21406417650856 1021 1840002
SGTC_2438 5259590 200 µM 0.791338295550197 0.206731614845985 no 635 0.214373303429277 1077 1201127
SGTC_186 3455-3465 67.277 µM 0.79098489762353 0.206838071309888 no 636 0.214476402236512 998 755278
SGTC_1172 0370-0043 85 µM 0.790470669417901 0.206993033722592 no 637 0.214626472468174 1061 376585
SGTC_2395 5646831 180.19 µM 0.789733679070863 0.207215245138351 no 638 0.214841659061975 1027 6808628
SGTC_1394 3474-0001 65.7 µM 0.787695035936312 0.20783065489287 no 639 0.215437554950368 969 5017666 YIL048W NEO1
SGTC_1508 1080-0625 72.9 µM 0.787463522008394 0.207900610704981 no 640 0.215505287099332 1004 767111
SGTC_901 1112-0062 60.1 µM 0.786995821970026 0.208041976517159 no 641 0.215642155971753 1091 1908457
SGTC_876 0720-0963 56.8 µM 0.785932872376324 0.208363471873513 no 642 0.215953407489001 1077 765861
SGTC_1459 k035-0031 35.7 µM 0.785718575543926 0.208428322688529 no 643 0.216016189121406 930 3877128 YMR208W ERG12
SGTC_695 3505-6186 243 µM 0.783269047734755 0.209170447615055 no 644 0.216734567668452 1069 1819379
SGTC_3108 9121785 49.47 µM 0.783180155510357 0.209197408202959 no 645 0.216760663243263 1053 17140271
SGTC_351 caspofungin 25 nM 0.782420294775656 0.209427953814988 no 646 0.216983805286509 1151 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1873 rapamycin 2 nM 0.782246652287666 0.209480658805858 no 647 0.217034816075192 1062 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1420 4'-methoxyflavone 42 µM 0.780823629810736 0.209912876896791 no 648 0.217453117062624 1090 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1349 flufenamic acid 69 µM 0.780588048514707 0.209984481111951 no 649 0.217522411644685 1010 3371 A non-steroidal anti-inflammatory.
SGTC_63 0099-0242 26.702 µM 0.779607240103838 0.210282749063625 no 650 0.21781104650335 1101 3898502 YLR359W ADE13
SGTC_245 methotrexate 289.6 µM 0.779511614695813 0.210311842455557 no 651 0.217839199212093 1067 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_970 1315-0089 19.5 µM 0.779303640730101 0.210375125305379 no 652 0.217900435273094 1046 6811083 YLR033W RSC58
SGTC_2757 clomiphene 4.22 µM 0.77889362806832 0.210499917745603 no 653 0.2180211888802 1143 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1226 3909-7979 35.4 µM 0.778418181029831 0.210644680337124 no 654 0.218161261983023 1086 6615510
SGTC_463 ikarugamyin 104 µM 0.778169406100157 0.210720449802536 no 655 0.218234575092664 1093 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_950 1165-0508 94.1 µM 0.778037319068671 0.21076068609197 no 656 0.218273506452054 1025 6148369
SGTC_1782 st039423 80.636 µM 0.777388051304962 0.210958531240764 no 657 0.21846492993464 1002 2068169
SGTC_2353 9059630 146.67 µM 0.777313395003329 0.210981287518587 no 658 0.218486947032554 1088 4779114
SGTC_273 hydroxyurea 18.1 mM 0.775834331523121 0.211432423215747 no 659 0.218923405111189 1151 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3124 9127567 49.47 µM 0.775731934526036 0.211463676672211 no 660 0.218953640078686 1035 17592030
SGTC_1141 3253-0389 52.6 µM 0.775380358692524 0.211571004704235 no 661 0.219057468861879 1075 5402031
SGTC_3145 9085516 49.47 µM 0.775350420850699 0.211580145513384 no 662 0.219066311533194 1059 25236195
SGTC_3087 9117406 49.47 µM 0.774803558861806 0.211747157516489 no 663 0.219227873014078 1071 42546093
SGTC_2344 7990960 76.95 µM 0.773601971292881 0.21211439400275 no 664 0.219583102996487 1017 140813
SGTC_1790 st045711 43.5 µM 0.77346455339338 0.212156416211671 no 665 0.219623749436546 1096 585119
SGTC_2836 9010338 19.48 µM 0.773430025328491 0.212166975612549 no 666 0.219633963071425 1038 2994051
SGTC_2521 angolensin 13.4 µM 0.772935286469751 0.212318310791598 no 667 0.219780340120154 1074 821428 A flavenoid.
SGTC_2020 4017018 200 µM 0.772769475573283 0.212369044633164 no 668 0.219829410668559 1096 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2895 9054447 58.44 µM 0.772690734374355 0.212393139882064 no 669 0.219852715765068 1092 2697450
SGTC_1808 st050063 61.5 µM 0.772506800638244 0.212449430861329 no 670 0.219907160306837 1069 4011993
SGTC_2897 9048598 12.99 µM 0.772040071705171 0.212592307439997 no 671 0.220045347187821 1078 6467404
SGTC_1646 st011709 75.6 µM 0.771095800941363 0.212881542236004 no 672 0.220325074673181 1061 5757843
SGTC_3292 9120825 59.784 µM 0.77085177959093 0.212956324507427 no 673 0.22039739584335 1103 24824900
SGTC_2080 5212524 12.4 µM 0.77079976758225 0.212972265980231 no 674 0.220412812521316 1054 260183
SGTC_848 0368-0089 85.6 µM 0.769391583749103 0.213404133266433 no 675 0.220830441676356 1092 762535
SGTC_1791 st048313 56.1 µM 0.769313681533607 0.213428039512411 no 676 0.220853558580309 1032 1204976
SGTC_474 dl-dihydrosphingosine 5 µM 0.769090827987873 0.213496436323863 no 677 0.220919696365592 1123 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1916 st067606 49.2 µM 0.766483325806169 0.214297663158865 no 678 0.221694384759679 1112 19590279
SGTC_2826 7992541 19.48 µM 0.765920053300601 0.214470973586447 no 679 0.221861936547071 1149 2985066
SGTC_1264 0783-0040 158 µM 0.765696621875866 0.214539742623704 no 680 0.221928418784357 1023 2855798
SGTC_2291 7917025 104.35 µM 0.765201931596601 0.214692046907728 no 681 0.222075654827293 1060 2964612
SGTC_1211 1056-0033 32.3 µM 0.7651256273753 0.214715544895546 no 682 0.222098370427535 1096 6741922
SGTC_942 3253-1115 227 µM 0.765065466137613 0.214734072683429 no 683 0.222116281231811 1106 46497897
SGTC_265 mycophenolic acid 32.932 µM 0.763637397979093 0.21517414588923 no 684 0.222541678187945 1161 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2100 5377183 190 µM 0.760677055916394 0.216088069878478 no 685 0.223424991175265 1140 2844202
SGTC_2963 9082507 9 µM 0.758691908366721 0.216702186756151 no 686 0.224018439216492 1067 16459611
SGTC_3192 9110362 49.47 µM 0.758322132072007 0.216816690610669 no 687 0.224129080493402 1130 16649480
SGTC_1967 st070177 51.4 µM 0.757131346819674 0.217185663340547 no 688 0.224485587816108 1105 5729214
SGTC_1142 3253-1408 9.78 µM 0.756441995273338 0.217399429168473 no 689 0.224692118665587 1100 256655
SGTC_995 3931-2021 34.6 µM 0.756037446215883 0.217524935149858 no 690 0.22481337238618 1069 730143
SGTC_2697 mebhydrolin 72.4 µM 0.755214268048801 0.217780444348578 no 691 0.225060214495537 1108 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_586 0957-0265 8.15 µM 0.75518601044553 0.217789218398936 no 692 0.225068690680019 1026 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1594 piperine 70.1 µM 0.755101856782832 0.217815349511231 no 693 0.225093934584804 1079 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1072 oxiconazole 14.9 nM 0.75479570418851 0.217910430240655 no 694 0.225185785914323 1095 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_153 4077-0274 519.67 µM 0.753012942964043 0.21846457135449 no 695 0.225721068195504 1098 3121976
SGTC_1043 0916-0009 19.3 µM 0.752835055113421 0.218519909270802 no 696 0.225774519310142 1181 3101130
SGTC_1124 fisetin 1.16336 µM 0.751025198702945 0.219083383759102 no 697 0.226318745385097 1048 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_779 1360-0071 233 µM 0.750825942354772 0.21914547056182 no 698 0.226378707265718 1181 7566
SGTC_955 1216-0110 33 µM 0.750037899014231 0.21939111812804 no 699 0.226615939727243 1068 3619719
SGTC_2014 4013930 200 µM 0.748283845775294 0.219938456346145 no 700 0.227144483131674 1113 64556
SGTC_1628 st004252 77.7 µM 0.747748668788141 0.220105609902337 no 701 0.227305884593064 1103 692968
SGTC_830 4076-0286 57.8 µM 0.747737600439556 0.22010906768431 no 702 0.227309223325169 1173 6866659
SGTC_1793 st048256 72.231 µM 0.747385435729776 0.22021910115595 no 703 0.227415467113626 1074 672022
SGTC_2493 resveratrol 26.09 µM 0.747270174248537 0.220255121327657 no 704 0.227450246168694 1054 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_396 dithiazanine 1.25 µM 0.746369497982286 0.220536706466804 no 705 0.227722119810491 1085 10578 An antihelmenthic.
SGTC_799 1310-0557 151 µM 0.746313281771318 0.220554288596636 no 706 0.22773909501801 1105 5354492
SGTC_1330 1469-0054 61.8 µM 0.743287332414184 0.221501866117183 no 707 0.228653869627487 1155 7102664
SGTC_1994 st072947 40.9 µM 0.742600545581056 0.2217172573404 no 708 0.22886177906062 1100 5286565 YDL195W SEC31
SGTC_2371 9071574 200 µM 0.740233835287949 0.222460424999696 no 709 0.229579060182487 1109 45596039
SGTC_1297 1068-0111 14.1 µM 0.740211140358804 0.222467558275074 no 710 0.229585944447089 1106 767057
SGTC_2855 9016525 58.44 µM 0.740179178002104 0.222477604629971 no 711 0.229595640083087 1172 43811474
SGTC_1957 st077035 62.4 µM 0.738780168803359 0.222917592307928 no 712 0.230020247868945 1177 705593
SGTC_509 pifithrin 175 µM 0.73762585093963 0.223280997610222 no 713 0.230370920970166 1177 4817 A p53 inhibitor.
SGTC_1758 st042942 75.2445 µM 0.735864035345306 0.223836306422988 no 714 0.230906723134227 1127 669317
SGTC_515 4092-1064 102 µM 0.734591580372043 0.224237860778896 no 715 0.23129413362649 1172 717353
SGTC_1414 3917-0015 5.4 µM 0.733772137892472 0.224496672310267 no 716 0.231543812143609 1133 6618702
SGTC_384 k007-0144 5.16 µM 0.733767814615179 0.224498038217278 no 717 0.231545129814926 1136 6824886
SGTC_3334 9142812 21.919 µM 0.732912352124371 0.224768407940453 no 718 0.231805944428304 1108 45283678
SGTC_615 k087-0205 167 µM 0.729711960607437 0.225781530561097 no 719 0.232783134289131 1132 9642773
SGTC_850 0388-0143 75.9 µM 0.729640722980883 0.225804111040963 no 720 0.232804911604018 1101 67273
SGTC_2584 androsterone 48.74 µM 0.729624053051174 0.225809395160705 no 721 0.23281000775852 1221 2754130 A steroid.
SGTC_429 1112-0049 25.5 µM 0.72869887090018 0.226102773772323 no 722 0.23309294181921 1089 2836170
SGTC_2928 9011484 9.79 µM 0.728451212256994 0.226181343760869 no 723 0.233168711788393 1123 2994751
SGTC_550 4123-0385 25.7 µM 0.727560648411334 0.226464003610395 no 724 0.233441288457905 1148 5731123
SGTC_1287 0971-0001 34.6 µM 0.727092586737117 0.226612643625993 no 725 0.233584619871719 1147 4665869
SGTC_2426 5582046 32.21 µM 0.726731149810154 0.226727461021352 no 726 0.233695333681616 1149 2251934
SGTC_1678 st019265 80.2 µM 0.725584589159947 0.227091905230324 no 727 0.234046735663747 1169 5367020
SGTC_2580 diallyl disulphide 81.36 µM 0.725205438209309 0.227212494260805 no 728 0.234163003552393 1119 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1659 st012954 42.1 µM 0.724775294564636 0.227349345213485 no 729 0.234294947231452 1113 24207262
SGTC_1929 genistein trimethyl ether 50.5 µM 0.724467992251005 0.227447142414808 no 730 0.234389235351367 1184 136420
SGTC_2432 5630864 12.22 µM 0.724294605669518 0.227502332156311 no 731 0.234442444003099 1116 5714970
SGTC_1209 2323-2347 50.3 µM 0.723255329495928 0.227833296556864 no 732 0.234761515787331 1154 5412760
SGTC_2833 9001315 45.46 µM 0.721205165154458 0.228486978749002 no 733 0.235391647177477 1133 2989378
SGTC_2073 5212005 126 µM 0.71848650689762 0.229355428806028 no 734 0.23622868231862 1041 691789
SGTC_2414 st077232 92.9 µM 0.718325963197852 0.229406770790507 no 735 0.236278162582729 1102 729801
SGTC_1755 st041960 45.185 µM 0.718280380279917 0.229421349412753 no 736 0.236292212475772 1158 2257073
SGTC_81 0411-0046 9.971 µM 0.7181410675573 0.229465908522894 no 737 0.236335155291057 1072 12925265
SGTC_1809 st050081 57.6 µM 0.717221373121949 0.22976019402802 no 738 0.236618756699821 1205 5036894
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.716889919423671 0.229866304974722 no 739 0.236721011239435 1107 6857784
SGTC_1277 0873-0036 22 µM 0.715697127607805 0.230248389966167 no 740 0.237089192412143 1202 5965735
SGTC_677 0929-0063 136 µM 0.71348191387315 0.230958927155179 no 741 0.237773800436449 1122 1539583
SGTC_1006 4099-6547 255 µM 0.712211254757982 0.231367047131955 no 742 0.238166984296783 1164 3146833
SGTC_75 0159-0059 199.013 µM 0.712196394221821 0.231371822530373 no 743 0.238171584743644 1174 5377270
SGTC_2170 morpholine 200 µM 0.711661666391954 0.231543692633722 no 744 0.238337155374621 1172 121171 Reacts with secondary amines.
SGTC_749 1000-0129 128 µM 0.711620664849923 0.231556874124237 no 745 0.238349853502468 1217 708470
SGTC_307 1501-1223 22.3 µM 0.711513035766734 0.231591477538293 no 746 0.238383187861786 1165 2830329
SGTC_1875 nocodazole 6 µM 0.710610411880819 0.231881790099692 no 747 0.238662844627077 1177 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1369 1866-0067 208 µM 0.70961857606307 0.232201029653189 no 748 0.238970348516743 1204 3531355
SGTC_875 0709-0210 25.7 µM 0.70927969628294 0.23231016002014 no 749 0.239075462765246 1208 6251364
SGTC_643 k048-0106 28.4 µM 0.708551395403853 0.232544793243407 no 750 0.23930145374559 1174 6763920
SGTC_233 rapamycin 362 pM 0.707061783787749 0.233025104421858 no 751 0.239764041852923 1205 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3208 9114115 49.47 µM 0.706731920858439 0.233131540061029 no 752 0.239866544342523 1147 650895
SGTC_2842 9000675 19.48 µM 0.705665902077333 0.233475692842103 no 753 0.240197965257723 1155 2989072
SGTC_3220 9131269 49.47 µM 0.705610581676883 0.233493560130868 no 754 0.240215170954692 1210 17722206
SGTC_752 1896-0090 130 µM 0.704914489020431 0.233718447750819 no 755 0.240431726400054 1175 772567
SGTC_1380 2291-0730 164 µM 0.704448769168394 0.233868975522626 no 756 0.240576671875531 1176 2999191
SGTC_2904 7225135 42.03 µM 0.704226813271474 0.233940733957611 no 757 0.24064576770012 1252 4446116
SGTC_1265 0819-1001 68.8 µM 0.702935179150712 0.234358561756304 no 758 0.241048073211504 1196 3106768
SGTC_2058 5236698 133 µM 0.701408538135877 0.234852943489857 no 759 0.24152404755084 1177 766665
SGTC_2046 4110841 106 µM 0.70115560959084 0.234934906551296 no 760 0.241602954571846 1198 44119630 YMR134W ERG29
SGTC_1591 genipin 88.4 µM 0.699215644018653 0.235564089688468 no 761 0.242208637686672 1154 442424 A DNA cross-linking agent.
SGTC_1360 1598-0022 39.8 µM 0.69679290258479 0.236351153737551 no 762 0.242966204215611 1211 761525
SGTC_1622 st003707 19.4 µM 0.696721804670034 0.236374272812602 no 763 0.242988455151493 1201 10140899
SGTC_2334 9017922 200 µM 0.69641590180003 0.236473758163725 no 764 0.243084203656498 1205 3163164
SGTC_573 3702-0553 84.7 µM 0.696113144175253 0.236572243308656 no 765 0.243178987776909 1181 1222756
SGTC_106 0092-0003 11.579 µM 0.696071114542357 0.236585917066795 no 766 0.243192147544364 1154 1072148
SGTC_2674 ligustilide 100 µM 0.696025197694172 0.236600855973544 no 767 0.243206524865752 1164 5319022 A signalling regulator.
SGTC_3172 9105863 49.47 µM 0.695999685224706 0.236609156602093 no 768 0.243214513438697 1169 2348785
SGTC_1200 1643-0193 18.4 µM 0.695517969073439 0.236765915788952 no 769 0.243365377071058 1202 5403974
SGTC_3146 9095609 49.47 µM 0.694171632747243 0.237204340829604 no 770 0.24378729006991 1209 17173999
SGTC_3207 9114163 49.47 µM 0.69324457067073 0.237506491209473 no 771 0.244078040860725 1242 849233
SGTC_1903 st060211 78.3 µM 0.693224595910279 0.237513003757213 no 772 0.244084307522948 1218 688960
SGTC_101 0490-5701 117.494 µM 0.692630470697712 0.237706756461186 no 773 0.244270741519147 1125 4661669
SGTC_1731 st035964 63 µM 0.692012048197681 0.237908524922728 no 774 0.244464881408089 1161 6739575
SGTC_275 trichlorophene 5.69 µM 0.691124837188753 0.238198153087563 no 775 0.244743546546101 1229 62616
SGTC_2735 sertaconazole 140 nM 0.69105297872055 0.238221619586976 no 776 0.244766124139961 1244 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_896 0964-0007 44.5 µM 0.689740102121186 0.238650582724424 no 777 0.245178821121937 1201 6756758
SGTC_2280 7785178 200 µM 0.68944871228111 0.238745847360411 no 778 0.24527046894937 1198 2954328
SGTC_3092 9117248 49.47 µM 0.688968860252331 0.238902771628971 no 779 0.245421431963794 1249 17141857
SGTC_191 3914-0123 66.505 µM 0.685896794524881 0.239908753411912 no 780 0.246389095850978 1139 3144412
SGTC_2357 9067248 200 µM 0.685751125512937 0.239956511640906 no 781 0.246435030569266 1202 9150235
SGTC_868 0527-0199 213 µM 0.68535374522337 0.2400868208834 no 782 0.246560362306889 1161 2849450
SGTC_551 k048-0028 34.9 µM 0.682636115067443 0.240979021400574 no 783 0.247418403650297 1217 6836383
SGTC_3251 9135047 49.47 µM 0.681633057100276 0.24130878129093 no 784 0.247735503347831 1196 17682963
SGTC_1611 st001856 99.4 µM 0.680506955555035 0.241679284289502 no 785 0.248091759588328 1182 647478
SGTC_1658 st012944 20 µM 0.679412158661915 0.242039783464729 no 786 0.248438374042654 1167 24207260
SGTC_1695 st026914 34.495 µM 0.678669566911284 0.242284472986656 no 787 0.248673626598 1193 3289191
SGTC_1648 st011736 69.8 µM 0.677494442126699 0.242671959148309 no 788 0.249046147613573 1245 2855514
SGTC_681 1642-0006 26.6 µM 0.676044442241202 0.243150544776851 no 789 0.249506214432203 1242 4446530
SGTC_2273 7815444 169.05 µM 0.67551559319051 0.243325223131627 no 790 0.249674123939463 1199 2824616
SGTC_2973 9094665 17.96 µM 0.675279693517663 0.243403162443704 no 791 0.249749041407151 1242 25237061 YIL048W NEO1
SGTC_2332 7982454 138.89 µM 0.672685029643832 0.244261307498066 no 792 0.250573846791434 1224 2981748
SGTC_1204 4049-0315 18.3 µM 0.671274902742768 0.244728368375605 no 793 0.251022709856637 1265 588402
SGTC_1650 st011916 45.8 µM 0.671113384409958 0.244781896997313 no 794 0.251074150538178 1227 242528
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.670823466768684 0.244877994106895 no 795 0.251166498075346 1240 5377381
SGTC_1748 st037455 53.6035 µM 0.670409807590941 0.245015142159829 no 796 0.251298292130823 1227 580690
SGTC_634 1611-4317 11.2 µM 0.669540511602624 0.24530349049688 no 797 0.251575373653183 1240 2843522
SGTC_3178 9107506 49.47 µM 0.669525100057427 0.245308604202224 no 798 0.25158028742233 1261 8897194
SGTC_1145 3546-0597 10.2 µM 0.668904388815141 0.245514610043415 no 799 0.251778235201902 1210 875334
SGTC_1322 1348-1070 12 µM 0.668612457456673 0.245611530321085 no 800 0.251871361931693 1220 6758089
SGTC_877 0771-0151 33.1 µM 0.667599530756798 0.245947978037509 no 801 0.252194628662891 1238 6166523
SGTC_993 3909-8757 62.7 µM 0.667075098776639 0.246122267367045 no 802 0.252362082489112 1217 4288324 YLR208W SEC13
SGTC_1234 0326-0494 15.5 µM 0.666224972042396 0.246404938515983 no 803 0.252633656785291 1277 1547813
SGTC_1815 st051655 58.2 µM 0.666078637983068 0.246453612827048 no 804 0.252680418950407 1215 5984156
SGTC_2244 6635614 200 µM 0.663880587298315 0.247185358137184 no 805 0.253383370947174 1160 836499
SGTC_508 roscovitine 141 µM 0.663434795082781 0.247333906844172 no 806 0.253526063688374 1280 160355 A CDKinase inhibitor.
SGTC_1480 1070-0044 41.2 µM 0.66322466481312 0.247403943857917 no 807 0.253593338504979 1246 3124987
SGTC_757 1066-0008 322 µM 0.662656834144993 0.247593256437172 no 808 0.253775180744506 1272 6842497
SGTC_395 anisomycin 6.25 µM 0.662332279053278 0.247701496611906 no 809 0.253879147089554 1200 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2012 4023501 200 µM 0.662005533432957 0.247810492855883 no 810 0.253983837715646 1219 3477460
SGTC_3037 9091026 49.47 µM 0.66151001181965 0.247975838470297 no 811 0.25414264807124 1267 25236398 YIL048W NEO1
SGTC_2352 9027995 87.8 µM 0.660596501868586 0.248280812639678 no 812 0.254435556494664 1228 2997347
SGTC_2961 9083290 32.55 µM 0.660263264118065 0.248392113411288 no 813 0.254542450084249 1229 17741490
SGTC_411 enrofloxacin 100 µM 0.658466601273349 0.248992653303339 no 814 0.255119175679283 1322 71188 A bacterial gyrase inhibitor.
SGTC_2077 5212015 200 µM 0.65843649334915 0.249002723544249 no 815 0.255128846088689 1169 780900
SGTC_1673 st016611 27.3 µM 0.656874585060077 0.249525434369841 no 816 0.255630780582058 1292 5226799
SGTC_1717 st033143 58.0435 µM 0.656439344589126 0.249671196469423 no 817 0.255770741183217 1285 674616
SGTC_2563 tomatine 8.54 µM 0.655482277908411 0.249991877236167 no 818 0.256078646467756 1267 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_947 3447-0010 211 µM 0.654749281320605 0.250237627391035 no 819 0.25631459510875 1271 748350
SGTC_815 1582-0027 36.9 µM 0.653249570944111 0.250740830904535 no 820 0.256797698685164 1295 3128206
SGTC_1880 MG-132 525 µM 0.65295075849286 0.250841156559332 no 821 0.256894012106132 1212 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2337 9009472 200 µM 0.652048257955372 0.251144298195652 no 822 0.257185020737838 1306 5742383
SGTC_1040 k898-0338 155 µM 0.65162537608586 0.251286406970715 no 823 0.257321436693594 1311 20969351
SGTC_2913 7966556 36.57 µM 0.651303787203402 0.251394504852609 no 824 0.257425202072753 1227 2976516
SGTC_1807 st050092 58.9 µM 0.651263610962276 0.251408011295674 no 825 0.257438167054907 1233 5008496
SGTC_843 0310-0051 143 µM 0.650492774411994 0.251667225273543 no 826 0.257686983783501 1266 2065037
SGTC_541 4513-1321 94 µM 0.650456247496874 0.251679511907349 no 827 0.257698777328071 1220 747515
SGTC_1656 st012921 11 µM 0.648532863834583 0.252326931728008 no 828 0.258320181075037 1223 6732821
SGTC_3295 9122362 53.5725 µM 0.647572909347312 0.25265038498338 no 829 0.25863061188642 1259 4730473
SGTC_2134 5324836 1.464 µM 0.647444958426219 0.252693514079885 no 830 0.258672003335606 1248 699272
SGTC_750 4073-0104 132 µM 0.647138033617926 0.252796986658577 no 831 0.258771305872407 1151 22330957
SGTC_2761 levamisole 97.89 µM 0.645449815620359 0.253366528745642 no 832 0.259317864888753 1310 26879 An alkaline phosphatase inhibitor.
SGTC_65 0798-0905 34.986 µM 0.645181554513737 0.253457092147715 no 833 0.259404769064462 1447 3602145
SGTC_3091 9116372 49.47 µM 0.644094248422819 0.253824334542859 no 834 0.259757159892244 1274 17169793
SGTC_1228 0124-0032 52.5 µM 0.643551184456941 0.254007861319445 no 835 0.259933256848007 1329 X1228
SGTC_2941 9056145 11.23 µM 0.643381540184836 0.254065206341514 no 836 0.259988279266659 1177 2119517
SGTC_1647 st011722 22.4 µM 0.639889839859295 0.255247016080366 no 837 0.261122109859877 1281 2854783
SGTC_709 3807-1509 243 µM 0.639281442482536 0.255453229429572 no 838 0.261319929322568 1319 1886677 YPL242C IQG1
SGTC_2205 7238770 200 µM 0.638406940496363 0.255749790068862 no 839 0.26160440707825 1310 279867
SGTC_903 1134-0042 114 µM 0.637970171757507 0.255897974122379 no 840 0.26174654857235 1281 701009
SGTC_2724 maprotiline 69.64 µM 0.633927290841149 0.257271740350908 no 841 0.263064137113018 1276 4011 A tricyclic antidepressant.
SGTC_657 3534-0529 86.7 µM 0.63295545572739 0.257602539366052 no 842 0.263381366017852 1341 1049549
SGTC_3225 9130819 49.47 µM 0.63285704397424 0.257636049655472 no 843 0.263413500721141 1310 4547121
SGTC_882 0843-0131 351 µM 0.632695042038433 0.257691218034279 no 844 0.263466404088416 1305 5425421
SGTC_1182 1222-0449 220 µM 0.63241091299104 0.257787990569208 no 845 0.263559202391814 1301 658318
SGTC_443 clozapine 122 µM 0.630278053698637 0.25851503056491 no 846 0.264256339549131 1225 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_742 0kpi-0133 140 µM 0.630191141897368 0.258544679192792 no 847 0.26428476706283 1334 2728852
SGTC_1830 st055982 50.3 µM 0.628704535471188 0.259052084703345 no 848 0.264771254148263 1266 455313 An antimicrobial agent.
SGTC_2119 5528445 120.635 µM 0.627873897905389 0.259335820323075 no 849 0.265043275710741 1338 791935
SGTC_357 1325-0123 420 µM 0.626601103573852 0.259770902601123 no 850 0.265460372376856 1293 1098503
SGTC_1044 1222-0021 1.78 µM 0.626321936521986 0.259866381273621 no 851 0.265551900364521 1313 4306703
SGTC_59 0330-0160 1.33 µM 0.625837019918669 0.260032271927137 no 852 0.26571092364801 1294 4293482
SGTC_2133 5320837 200 µM 0.625174364581526 0.260259055515391 no 853 0.26592831251676 1316 2841355
SGTC_2243 6634756 200 µM 0.62515017220957 0.260267336910195 no 854 0.265936250703754 1365 885676
SGTC_2234 tolnaftate 200 µM 0.624892562590188 0.260355528786237 no 855 0.266020786996839 1297 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_252 miconazole 1.30953 nM 0.623776837645498 0.260737671501416 no 856 0.266387076558795 1267 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_285 1486-1325 46 µM 0.62323980686377 0.260921710715944 no 857 0.266563473280685 1327 22310230
SGTC_1179 1021-1431 9.29 µM 0.623217190888948 0.260929462624246 no 858 0.266570903170977 1313 2840958
SGTC_625 k213-0058 121 µM 0.623124568710518 0.26096121127041 no 859 0.266601332871267 1364 3655420
SGTC_2821 7996764 71.43 µM 0.622922879713944 0.261030352259967 no 860 0.266667601000441 1359 2987135
SGTC_1728 st035614 33.7865 µM 0.622874864875393 0.261046813610944 no 861 0.266683378266767 1352 15945546
SGTC_2034 5197015 53.07 µM 0.617859022829995 0.262769374075131 no 862 0.268334136243261 1377 780676
SGTC_1423 4048-0112 5.59 µM 0.615034787870833 0.263741836141735 no 863 0.269265873315146 1325 X1423
SGTC_132 0417-1715 25.805 µM 0.61403665455585 0.264085959444133 no 864 0.269595552895511 1357 6769098
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.610865866433569 0.265180657695382 no 865 0.270644191869157 1291 75037 A free radical scavenger.
SGTC_3280 9140961 49.47 µM 0.609677860612117 0.265591403200667 no 866 0.271037611559459 1307 4901226
SGTC_1253 0550-0034 176 µM 0.609593513978572 0.265620577779617 no 867 0.271065554609969 1315 5969915
SGTC_2736 butenafine 14.65 µM 0.60892948224737 0.265850315849247 no 868 0.271285590705831 1322 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1 0258-0098 57.368 µM 0.608587460463262 0.265968685956256 no 869 0.271398959079066 1261 6790032 YDR047W HEM12
SGTC_237 nikkomycin 200 µM 0.607689640862398 0.266279538771841 no 870 0.271696667440809 1386 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2709 st078560 56 µM 0.60768915058335 0.266279708571779 no 871 0.271696830057034 1368 17250903
SGTC_308 4092-1169 104 µM 0.606662966736672 0.26663523021943 no 872 0.272037301840244 1316 2268590 YDL196W YDL196W
SGTC_1317 1273-0028 910 nM 0.606630069163928 0.266646631560517 no 873 0.272048220250145 1320 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2977 9011197 71.43 µM 0.606343678081891 0.266745896784433 no 874 0.272143280091012 1379 2704722
SGTC_2712 st079126 47.7 µM 0.60607673516407 0.266838437948449 no 875 0.27223189950049 1298 3152970
SGTC_2413 inermin 26.06 µM 0.604120427256771 0.267517126358755 no 876 0.272881789732145 1466 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2314 7727897 200 µM 0.604046569306671 0.267542766428755 no 877 0.272906340587264 1315 900724
SGTC_3151 9099821 49.47 µM 0.603448110295153 0.267750569449327 no 878 0.273105312578937 1287 17174189
SGTC_1746 st038117 42 µM 0.603231980884172 0.267825636083961 no 879 0.27317718763028 1352 2898218
SGTC_1855 st056195 39.6 µM 0.603188807350651 0.267840632499355 no 880 0.27319154635475 1344 4028379
SGTC_416 estradiol valerate 100 µM 0.601738555117408 0.268344626206588 no 881 0.273674090756845 1337 13791 A steroid.
SGTC_2544 sphondin 68.51 µM 0.599580971940289 0.269095314209367 no 882 0.27439276575898 1377 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_503 tyrphostin 8 294 µM 0.59894415320033 0.269317083828468 no 883 0.274605063283625 1326 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1189 1431-2119 7.28 µM 0.598375547773614 0.269515175851308 no 884 0.274794688844036 1357 3107275
SGTC_841 0251-0215 91.2 µM 0.598175983387128 0.269584717843484 no 885 0.274861257340757 1373 3888614
SGTC_698 k064-0052 127 µM 0.597952662671683 0.269662548837054 no 886 0.274935759635165 1400 5088751
SGTC_1911 st060208 74.3 µM 0.597732521331531 0.269739282780672 no 887 0.275009210992223 1402 688783
SGTC_1346 1488-2224 62.4 µM 0.596753581321972 0.270080641063962 no 888 0.275335956685952 1345 3722427
SGTC_1152 3909-8331 15.9 µM 0.595914578087959 0.270373375010233 no 889 0.275616146937333 1324 16001939
SGTC_1854 st056233 32.9 µM 0.595672400841426 0.270457901787842 no 890 0.275697049573249 1322 5393174
SGTC_2656 pseudo-anisatin 100 µM 0.595599931620198 0.270483198183083 no 891 0.275721261181122 1348 6708809 A neurotoxin.
SGTC_3304 9125678 46.087 µM 0.594587292260563 0.270836797743982 no 892 0.276059688266603 1348 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1796 st049173 110.4 µM 0.591759425863318 0.271825469492017 no 893 0.277005848294041 1312 94134
SGTC_1643 st009866 20.2 µM 0.590557374140633 0.272246271134825 no 894 0.277408516311876 1346 3156273 YOR207C RET1
SGTC_1389 3405-0187 19 µM 0.590182253608755 0.272377655633055 no 895 0.277534234223074 1305 799890
SGTC_1713 st033146 12.748 µM 0.589447921882842 0.272634943587676 no 896 0.277780418759419 1414 674619
SGTC_548 1436-0017 110 µM 0.58735806546638 0.273367826498284 no 897 0.27848162562815 1431 9677137
SGTC_1175 0741-0056 27.6 µM 0.586279086824803 0.273746590450299 no 898 0.278843991205621 1442 765927
SGTC_569 4130-2812 160 µM 0.585108039643137 0.274157967601048 no 899 0.279237536673612 1311 743552
SGTC_1034 k072-0165 12.7 µM 0.58347997779107 0.274730396345042 no 900 0.279785115917142 1392 5835461
SGTC_2702 st077768 96.8 µM 0.582201605539181 0.275180286417907 no 901 0.280215446020781 1313 6484119
SGTC_2788 5282734 71.43 µM 0.581422546013587 0.275454634057129 no 902 0.280477852896544 1478 743706
SGTC_1207 2099-0101 141 µM 0.581181050199646 0.275539704685738 no 903 0.280559218914361 1389 5837381
SGTC_1603 st002045 67.8 µM 0.581019049067764 0.275596779325722 no 904 0.280613807573569 1345 5887985
SGTC_2297 7971671 152.32 µM 0.580605110536192 0.27574264046246 no 905 0.280753313574028 1434 909016
SGTC_78 0336-0123 156.75 µM 0.580286547396591 0.275854919629781 no 906 0.280860698893194 1327 6765896
SGTC_2171 5739187 198.077 µM 0.57992350328804 0.275982903716258 no 907 0.280983102627786 1311 2262761
SGTC_1269 0831-0796 3.05 µM 0.579735502166647 0.276049191286482 no 908 0.281046499103219 1381 927758
SGTC_2202 7226349 200 µM 0.57935078999928 0.276184861832912 no 909 0.281176250692539 1328 844334
SGTC_504 lovastatin 124 µM 0.578474379503721 0.276494054237121 no 910 0.281471944989038 1333 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2245 6637752 200 µM 0.577248212852952 0.276926923162133 no 911 0.281885895995109 1386 681890
SGTC_1708 st033234 31.827 µM 0.576729450491462 0.277110159692063 no 912 0.282061117217584 1438 674664
SGTC_2457 5731572 11.68 µM 0.574672913417713 0.277837150168061 no 913 0.282756264846441 1453 2865357
SGTC_1395 3486-0190 4.35 µM 0.574560052397909 0.277877073728339 no 914 0.282794437774077 1448 6748079
SGTC_725 1497-0963 19 µM 0.573420756175778 0.278280246158532 no 915 0.283179919944021 1442 3549977
SGTC_1003 4049-0218 100 µM 0.572841167844798 0.278485459386609 no 916 0.283376121010923 1433 295161
SGTC_1143 3454-2408 5.08 µM 0.572592203323306 0.278573632193314 no 917 0.28346041998259 1324 X1143
SGTC_539 4859-0462 2.54 µM 0.57100686061533 0.279135412922153 no 918 0.283997496151725 1400 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1137 ixabepilone 100 µM 0.570675189348917 0.279253013307968 no 919 0.284109919994892 1361 154225 A novel microtubule stabilizer.
SGTC_3315 9136395 68.55 µM 0.567477282959211 0.28038812573779 no 920 0.285194978209831 1413 16876844
SGTC_341 1486-1430 230 µM 0.565921605037594 0.280941127769023 no 921 0.285723536958609 1343 2054753 YPL210C SRP72
SGTC_921 1561-0023 372 µM 0.565494708351725 0.28109297028258 no 922 0.285868661260969 1382 24050882
SGTC_2359 9039622 200 µM 0.565246211828986 0.281181376047576 no 923 0.285953154239695 1355 6463596
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.564976436345675 0.281277367269539 no 924 0.286044895858098 1405 688798
SGTC_713 1488-1073 324 µM 0.564914334920904 0.281299466371539 no 925 0.286066016455704 1372 3312542
SGTC_321 4534-3890 65.3 µM 0.564040224733315 0.281610611740886 no 926 0.286363378555031 1421 699746
SGTC_1054 3429-0080 167 µM 0.563582030087377 0.281773775465537 no 927 0.28651930962526 1444 1162877
SGTC_1299 1079-1439 3.74 µM 0.563398505268244 0.281839141676638 no 928 0.286581777394866 1347 323161
SGTC_3123 9126162 49.47 µM 0.562283130619546 0.282236562814663 no 929 0.286961565004127 1427 25239884
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.561837891006787 0.282395282221863 no 930 0.28711323666296 1405 442882
SGTC_6 0844-0013 19.835 µM 0.559348807932202 0.283283382760658 no 931 0.287961845644398 1482 1584900
SGTC_2830 7992007 71.43 µM 0.557558899377288 0.283922845881964 no 932 0.288572814406797 1413 1952075
SGTC_2591 skatole 100 µM 0.555537993985527 0.284645664230631 no 933 0.289263364948728 1412 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2120 5538279 151.968 µM 0.555087996511977 0.284806734589162 no 934 0.289417236345559 1440 2058197
SGTC_2116 5511452 16.8835 µM 0.554640779349098 0.284966852850138 no 935 0.289570195132112 1421 870744
SGTC_3230 9131665 49.47 µM 0.554227110878708 0.285114997800577 no 936 0.289711713259689 1371 15943720
SGTC_697 0508-1955 564 µM 0.554170278439461 0.285135353776153 no 937 0.289731158467338 1434 6243113
SGTC_303 1348-1668 34.2 µM 0.554063507259803 0.285173598447792 no 938 0.28976769186102 1416 5380509
SGTC_2878 9043973 25.97 µM 0.554041196857686 0.285181590182778 no 939 0.289775325979656 1469 6465167
SGTC_2123 5259487 200 µM 0.552898191425686 0.285591165096443 no 940 0.290166562971672 1431 2173474
SGTC_1687 st020778 55.3625 µM 0.552809692192566 0.285622888837487 no 941 0.290196865513956 1422 4259299
SGTC_883 0850-0245 24.6 µM 0.552759084888456 0.285641030460268 no 942 0.29021419435269 1499 6823229 YPR165W RHO1
SGTC_1571 st070080 73.4 µM 0.551095754333842 0.286237603396626 no 943 0.290784017860738 1507 4315245
SGTC_1972 st070201 17.4 µM 0.550422094839933 0.286479387476571 no 944 0.291014948762327 1442 2829099
SGTC_1356 1502-0781 85.8 µM 0.549602758168637 0.286773587299868 no 945 0.291295933313019 1384 567702
SGTC_1447 4239-0816 81.9 µM 0.548682492045081 0.287104198601631 no 946 0.291611681659287 1347 1341554
SGTC_1304 1165-0502 251 µM 0.547206898686128 0.287634691018807 no 947 0.292118298598396 1439 767425
SGTC_2178 5812956 200 µM 0.545448980551274 0.288267286434036 no 948 0.292722380494076 1416 5403383
SGTC_2468 5987765 72.9 µM 0.545390721389191 0.288288262506023 no 949 0.292742410299368 1471 26772094
SGTC_2258 7960471 200 µM 0.541965630823498 0.289522721381407 no 950 0.293921091346663 1366 2974708
SGTC_1715 st032160 10.2275 µM 0.541471991972346 0.289700841387641 no 951 0.294091148742662 1430 5289825
SGTC_2326 6164455 177.58 µM 0.541381047837117 0.289733662424473 no 952 0.294122483738403 1417 2888790
SGTC_2605 digitonin 300 nM 0.540759934822559 0.289957863958517 no 953 0.294336530792653 1470 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2780 5215298 71.43 µM 0.539556174172477 0.290392613734463 no 954 0.294751573686106 1461 2834131
SGTC_2007 4011539 71.82 µM 0.537563497275555 0.291112958208929 no 955 0.295439218323531 1419 45595301
SGTC_2937 9044753 11.33 µM 0.535321821596941 0.291924310740645 no 956 0.296213669709981 1389 6465530 YGL099W LSG1
SGTC_2920 7982904 15.77 µM 0.534322106279674 0.292286487133308 no 957 0.296559350136759 1403 6456808
SGTC_1795 st049545 62.3 µM 0.533208989900624 0.292689992133995 no 958 0.296944459559536 1432 5291882
SGTC_2411 st077133 39.94 µM 0.532914524473195 0.292796779193634 no 959 0.29704637522354 1581 1403142 YNL221C POP1
SGTC_585 0kpi-0023 191 µM 0.532416932462146 0.29297727063654 no 960 0.297218630158005 1478 64601
SGTC_1998 st075797 76.8 µM 0.531622482619375 0.293265548218283 no 961 0.297493745054752 1430 24208315
SGTC_3042 9091578 49.47 µM 0.529790112540789 0.293930950978121 no 962 0.298128730648705 1398 25236497
SGTC_588 3970-1144 52.9 µM 0.528861918886998 0.294268279333313 no 963 0.298450620308434 1435 1888707
SGTC_3237 9133362 49.47 µM 0.527895299800355 0.294619762384651 no 964 0.2987860035782 1489 43845137
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.526733875609732 0.295042336637488 no 965 0.299189203841823 1419 4620898
SGTC_2799 7812892 81.82 µM 0.525088180850501 0.295641586187785 no 966 0.299760945990334 1512 20205235
SGTC_2367 9070478 135.38 µM 0.523867747103895 0.296086345693298 no 967 0.300185264535532 1468 572802
SGTC_2459 5811157 9.22 µM 0.523799173552938 0.296111344883318 no 968 0.300209114139818 1412 2870684 YBR192W RIM2
SGTC_1874 staurosporine 7.6 µM 0.522875572535353 0.296448147423008 no 969 0.300530422285227 1525 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_393 acivicin 6.25 µM 0.522091767513874 0.296734109272839 no 970 0.300803219072159 1430 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2976 9009005 19.48 µM 0.521326392945725 0.297013468808442 no 971 0.30106970904363 1588 2993148
SGTC_1466 k213-0079 57.5 µM 0.52028213825775 0.297394812698693 no 972 0.301433471690111 1438 3657981
SGTC_1568 digitonin 820 nM 0.518784569988849 0.297942088912951 no 973 0.301955489582071 1590 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1080 nisoldipine 24.4 µM 0.517458188142318 0.298427189242948 no 974 0.302418174652626 1440 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1418 3966-3099 2.4 µM 0.516089615322026 0.298928096577991 no 975 0.302895910288115 1518 740335
SGTC_2145 5634607 200 µM 0.515941882697878 0.298982190594291 no 976 0.302947500367077 1427 308662
SGTC_339 3091-4833 71.4 µM 0.515758301697495 0.299049417103882 no 977 0.30301161462656 1475 3240077
SGTC_2484 5809818 12.04 µM 0.515330097832418 0.29920625003823 no 978 0.303161185141383 1467 2870548
SGTC_1323 1348-1351 11.2 µM 0.514378465070488 0.299554926372273 no 979 0.303493706195782 1453 6989654
SGTC_3345 9148410 3.559 µM 0.514239744515654 0.299605768679726 no 980 0.303542191757218 1524 4903596
SGTC_965 1291-5240 308 µM 0.512869504622706 0.300108183610969 no 981 0.304021303254287 1556 2834598
SGTC_2219 9098279 200 µM 0.512788171851174 0.300138017226482 no 982 0.304049752276379 1486 902349
SGTC_1437 4092-1038 11.6 µM 0.512463287566578 0.300257201174439 no 983 0.304163403914702 1420 3977136
SGTC_201 4262-0159 12.803 µM 0.511811137307307 0.300496507345113 no 984 0.304391597467799 1512 1341029
SGTC_1093 fluphenazine 7.97 µM 0.511335148811819 0.300671225417544 no 985 0.304558198446501 1502 6602611 An atypical antipsychotic.
SGTC_1286 0929-0070 131 µM 0.51076050026772 0.30088221907722 no 986 0.304759385510801 1520 1420408
SGTC_630 4356-0227 183 µM 0.51057761914875 0.300949381527849 no 987 0.304823425411666 1478 779312
SGTC_531 3788-1495 174 µM 0.507873194748367 0.301943359946026 no 988 0.305771137129772 1460 2896655
SGTC_95 0471-0001 561.058 µM 0.507013531686005 0.302259627324186 no 989 0.306072662025309 1360 4015405
SGTC_111 0083-0039 52.457 µM 0.50455281039224 0.303165739652066 no 990 0.306936480601749 1430 759313
SGTC_2293 7624732 200 µM 0.502962017888394 0.303752163486386 no 991 0.307495488288017 1411 894453
SGTC_2188 6126565 140.678 µM 0.501863920637633 0.304157257026773 no 992 0.307881622968725 1505 874518
SGTC_103 0844-0104 51.839 µM 0.501427269872923 0.304318406527679 no 993 0.308035225917672 1518 5375804
SGTC_31 0508-1974 57.237 µM 0.501425173419764 0.304319180332394 no 994 0.308035963479237 1495 6810525
SGTC_1434 4073-0095 163 µM 0.50135996941497 0.304343247687793 no 995 0.308058903547825 1480 24133745
SGTC_1501 4491-0275 38.4 µM 0.497823142127674 0.305649988278143 no 996 0.309304351533596 1487 5104718
SGTC_400 oxethazaine 37.5 µM 0.496436456089342 0.306163000352864 no 997 0.309793254688356 1476 4621 A local anesthetic.
SGTC_3173 9105693 49.47 µM 0.495651088723098 0.30645372008034 no 998 0.310070300624291 1531 17096658
SGTC_2203 7227154 166.4 µM 0.495007932290687 0.306691888305901 no 999 0.310297260620021 1478 896304
SGTC_1187 1391-0724 117 µM 0.493922145474125 0.307094152882802 no 1000 0.310680582008633 1508 6997986
SGTC_1618 st003135 44.5 µM 0.493560169275509 0.307228310236095 no 1001 0.310808418208696 1476 1270615
SGTC_1180 1193-0155 285 µM 0.493037944068356 0.307421905309533 no 1002 0.310992888495746 1474 2921347
SGTC_1826 st055655 41.6 µM 0.490960799287563 0.308192458294417 no 1003 0.311727086804699 1507 676168
SGTC_3110 9122132 49.47 µM 0.490158281166606 0.308490393135942 no 1004 0.312010949754495 1572 918317
SGTC_837 0091-0265 12.5 µM 0.490018655524787 0.30854224204239 no 1005 0.312060348892112 1452 759367
SGTC_2304 7443016 91.4 µM 0.489870049100569 0.30859743008751 no 1006 0.312112929116922 1463 939854
SGTC_257 daunorubicin 18.5 µM 0.489511599760629 0.308730565397132 no 1007 0.31223977213577 1625 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1435 4092-0789 56.7 µM 0.489421910104155 0.308763881876542 no 1008 0.312271513733897 1576 2248285
SGTC_1596 piperlongumine 63 µM 0.487821510976689 0.309358636954425 no 1009 0.312838136705426 1603 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.485875936552095 0.310082342344669 no 1010 0.313527565246413 1563 6710655
SGTC_359 0081-0058 15.9 µM 0.48517851185786 0.310341946450343 no 1011 0.313774861654819 1651 3494159
SGTC_852 0418-0143 439 µM 0.485026103138105 0.310398690511396 no 1012 0.31382891466308 1522 5369229
SGTC_1912 st060209 90.8 µM 0.48499462981739 0.310410409064818 no 1013 0.31384007743342 1450 688787
SGTC_989 1501-0895 10.3 µM 0.483811588224354 0.310851033883499 no 1014 0.314259795098175 1554 2830112
SGTC_1883 5-benzylidenerhodanine 20 µM 0.483095853571167 0.311117741643529 no 1015 0.31451383902758 1586 1273210
SGTC_1927 st060202 13.8 µM 0.480308361852734 0.312157403163603 no 1016 0.31550407196193 1546 688887
SGTC_2786 7743617 45.45 µM 0.48004261715417 0.312256597315104 no 1017 0.315598544886621 1411 583674
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.479732402445891 0.312372407941562 no 1018 0.315708842260575 1469 6708630 An antioxidant.
SGTC_1032 k061-1018 98.7 µM 0.479701095802428 0.312384096495951 no 1019 0.315719974303652 1657 4005393
SGTC_366 0181-0206 4.31 µM 0.478771857451578 0.312731120056158 no 1020 0.316050469760149 1670 274874
SGTC_48 0382-0018 55 µM 0.478208358001496 0.312941639524311 no 1021 0.316250957164299 1636 762596
SGTC_1008 4106-0037 6 µM 0.477137319756333 0.313341940091494 no 1022 0.316632170646516 1511 2905394
SGTC_326 k292-0812 17.5 µM 0.475858088610912 0.313820341059672 no 1023 0.317087741334279 1556 3579357
SGTC_2054 5233173 129 µM 0.475429354320895 0.313980747243251 no 1024 0.317240487934771 1550 6889
SGTC_821 1114-0266 29.2 µM 0.474685696715961 0.314259061856919 no 1025 0.317505507152519 1500 3123235
SGTC_2771 fluoxetine 41.05 µM 0.47264162003048 0.315024603497322 no 1026 0.318234441864088 1557 3386 A selective serotonin reuptake inhibitor.
SGTC_2153 5569715 200 µM 0.472479362329622 0.31508540589013 no 1027 0.318292334522244 1544 2054701
SGTC_1424 4048-1941 275 µM 0.472044848311977 0.315248254833497 no 1028 0.318447388595898 1631 X1424
SGTC_444 curcumin 90.4 µM 0.47188391063138 0.315308580830566 no 1029 0.318504826445757 1533 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2565 isoliquiritigenin 100 µM 0.471729343734257 0.315366523434492 no 1030 0.318559994701624 1436 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_29 0299-0004 12.984 µM 0.471676076511378 0.315386492808869 no 1031 0.31857900785324 1470 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1621 st003705 32.4 µM 0.469121650088693 0.316344755061371 no 1032 0.319491342349564 1619 24207032
SGTC_134 0269-0018 6.916 µM 0.468391268441343 0.316618976167741 no 1033 0.319752405502289 1472 4378915
SGTC_3034 9090421 49.47 µM 0.467771930891851 0.316851584873869 no 1034 0.319973847722938 1545 17173761
SGTC_720 r052-1644 49.9 µM 0.467694336254965 0.316880732712336 no 1035 0.320001595969105 1506 1422863 YOR257W CDC31
SGTC_71 0417-1750 47.813 µM 0.466228965450378 0.317431401419659 no 1036 0.320525809133305 1667 6811472
SGTC_639 0833-0042 114 µM 0.465586106736143 0.317673107650095 no 1037 0.320755894755091 1498 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1971 st069429 63.5 µM 0.464074544418911 0.318241740871695 no 1038 0.321297169403724 1584 1246522 YGL099W LSG1
SGTC_2347 9049783 174.81 µM 0.464065171104285 0.318245268348639 no 1039 0.321300527075577 1599 6467988 YPL169C MEX67
SGTC_1084 voriconazole 435 nM 0.46212105408574 0.318977257368258 no 1040 0.321997256340041 1566 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_225 nsc-122657 1.016 µM 0.461226351730003 0.319314363720998 no 1041 0.322318108750249 1553 275685
SGTC_1324 1418-0026 34.4 µM 0.460469240772057 0.319599745065026 no 1042 0.322589722473247 1561 1372513
SGTC_549 1661-1316 519 µM 0.460210042158732 0.319697470562659 no 1043 0.322682731800994 1640 2857282
SGTC_1567 st069303 68.4 µM 0.459691468401477 0.319893025688993 no 1044 0.32286884710173 1533 5581319
SGTC_2354 9060492 162 µM 0.459610909747267 0.319923409001075 no 1045 0.322897763458164 1643 6471895
SGTC_158 k038-0087 26.446 µM 0.45691453214049 0.320941064261918 no 1046 0.323866239156879 1575 X158
SGTC_2953 9074162 66.49 µM 0.455962509114914 0.321300694780385 no 1047 0.324208469009969 1684 16451992
SGTC_1355 1499-0035 1.68 µM 0.45593081536656 0.32131267010574 no 1048 0.324219864723013 1509 1548538
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.455264625372549 0.32156442966021 no 1049 0.324459436176529 1686 551469
SGTC_483 fpl-64176 144 µM 0.45524807806247 0.321570684090389 no 1050 0.324465387751286 1548 3423
SGTC_3105 9121040 49.47 µM 0.455087651223049 0.321631323665465 no 1051 0.324523090833092 1482 41448907
SGTC_545 4218-0007 221 µM 0.454402149533696 0.321890489264148 no 1052 0.324769702759384 1544 2840508
SGTC_2448 5185112 27.17 µM 0.454343812362389 0.321912548629289 no 1053 0.324790693334662 1522 5718189
SGTC_1000 4048-0884 8.67 µM 0.454054801827003 0.322021843075812 no 1054 0.324894691795648 1578 13040088
SGTC_2865 9030313 51.95 µM 0.452651159759317 0.322552873967831 no 1055 0.325399976758759 1497 42562754
SGTC_534 k292-0788 63.4 µM 0.451251955230359 0.323082586550553 no 1056 0.325903983910152 1669 4146317
SGTC_1788 fluconazole 20 µM 0.450493020124619 0.323370055386108 no 1057 0.326177492963096 1523 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1131 3454-3128 32.3 µM 0.449789690861229 0.323636556061948 no 1058 0.326431045990322 1662 710982
SGTC_104 0074-0074 590.992 µM 0.449194004974538 0.32386234002163 no 1059 0.326645855898001 1537 3943124
SGTC_1294 1000-1494 117 µM 0.448868304831698 0.323985818187827 no 1060 0.326763330731197 1500 712797 YDL207W GLE1
SGTC_1798 st045719 60.953 µM 0.448263037013853 0.324215336395208 no 1061 0.326981686763921 1532 3980186
SGTC_2491 paeonol 100 µM 0.447929923198764 0.324341682023738 no 1062 0.327101885974438 1524 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1554 st069299 38.7 µM 0.447258866237205 0.324596266384844 no 1063 0.327344081438922 1568 24207999
SGTC_2110 5483698 200 µM 0.446462719014213 0.324898413583433 no 1064 0.327631518317659 1565 2848765 YHR062C RPP1
SGTC_3273 9137859 49.47 µM 0.443688902152848 0.325952008566463 no 1065 0.328633760097849 1608 2377234
SGTC_1092 toremifene 6.32 µM 0.443180169354829 0.326145394725769 no 1066 0.32881771070613 1559 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3188 9110789 49.47 µM 0.441415940780202 0.326816398342483 no 1067 0.329455951979541 1631 849217
SGTC_2497 7-hydroxyflavone 100 µM 0.44125174256028 0.326878877747792 no 1068 0.329515378942309 1624 5281894
SGTC_2481 5478948 45.16 µM 0.440994704734306 0.326976693490192 no 1069 0.329608415254648 1542 77792
SGTC_300 r073-0011 5.04 µM 0.438822969010059 0.327803621514415 no 1070 0.330394907934853 1588 2735780
SGTC_1292 0kpi-0043 232 µM 0.438744914327538 0.327833358016005 no 1071 0.330423189365599 1545 3333905
SGTC_1325 1431-0015 227 µM 0.435543997260051 0.329053750253852 no 1072 0.331583805293101 1496 1103340
SGTC_2398 5228213 48.84 µM 0.435170739610356 0.329196178713443 no 1073 0.331719249848862 1740 80771 YMR134W ERG29
SGTC_2388 9080168 200 µM 0.434236500384697 0.329552776390324 no 1074 0.332058355038908 1502 15943073
SGTC_1205 4161-2785 76 µM 0.434214098761654 0.329561328960072 no 1075 0.3320664879512 1496 3498106
SGTC_2645 abamectin 100 µM 0.433717017003764 0.329751129495509 no 1076 0.332246973898615 1623 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3203 9113543 49.47 µM 0.433584777718343 0.329801629757149 no 1077 0.332294995357238 1629 17018012
SGTC_2349 9023730 187.07 µM 0.433452982997732 0.329851963333016 no 1078 0.332342858115926 1672 4126287
SGTC_1828 st055811 49 µM 0.433205252125725 0.329946582294223 no 1079 0.332432831812385 1663 5877589
SGTC_53 0973-0023 39.979 µM 0.43264136208341 0.330161996458347 no 1080 0.332637667766134 1669 674768
SGTC_2868 9035608 32.47 µM 0.432138756038901 0.330354046715525 no 1081 0.332820284120523 1527 6462614
SGTC_2689 tacrolimus 100 µM 0.43117025846702 0.330724244288918 no 1082 0.333172288847328 1565 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1640 st009078 66.4 µM 0.430286378932492 0.331062242123557 no 1083 0.333493667097289 1654 690618
SGTC_980 1473-0395 201 µM 0.429429606653696 0.331390005532538 no 1084 0.333805305845645 1545 768876
SGTC_1377 2944-0135 198 µM 0.428956858340887 0.331570913578304 no 1085 0.333977310439073 1632 1894137
SGTC_418 lividomycin a 100 µM 0.428354447230131 0.331801497022824 no 1086 0.334196542046816 1651 72394 An antibiotic.
SGTC_2428 5615643 7.78 µM 0.428295586953621 0.331824030247728 no 1087 0.334217965724562 1622 2253075
SGTC_566 0958-0068 16.5 µM 0.42752078364429 0.332120701533216 no 1088 0.33450002519635 1609 6815365
SGTC_3255 9139072 49.47 µM 0.427384420822942 0.33217292559629 no 1089 0.334549676405322 1583 17646060
SGTC_3058 9093861 49.47 µM 0.426592804694365 0.332476162110319 no 1090 0.334837969714321 1608 17217477
SGTC_1472 k841-0093 193 µM 0.426462978403594 0.332525903848864 no 1091 0.334885259568692 1659 X1472
SGTC_2517 totarol 10 µM 0.423201486946399 0.333776479701622 no 1092 0.336074131004153 1526 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3352 9151559 45.5865 µM 0.422713692441577 0.333963677327473 no 1093 0.336252082161873 1542 17159339
SGTC_951 1171-0579 82.7 µM 0.422634001430425 0.333994263740471 no 1094 0.336281157539083 1512 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_743 1275-0778 158 µM 0.422022877995862 0.334228857246386 no 1095 0.336504159320054 1700 2849257 YMR203W TOM40
SGTC_1333 1482-0047 286 µM 0.420929356460509 0.334648791727485 no 1096 0.336903333914408 1675 3811116
SGTC_1720 st037298 9.481 µM 0.420106347178512 0.334964980510045 no 1097 0.337203883061175 1575 597396
SGTC_805 3852-0218 479 µM 0.419921621334327 0.335035965711346 no 1098 0.337271356120342 1550 6615355
SGTC_715 0868-0130 184 µM 0.419777319904553 0.335091420991206 no 1099 0.337324067378033 1751 2876258
SGTC_2764 methyldopa 94.69 µM 0.419201214980517 0.335312854889311 no 1100 0.337534542116059 1693 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_820 1582-0060 59.9 µM 0.418679077701076 0.335513595020852 no 1101 0.337725344179772 1569 3848840
SGTC_640 3381-0960 37.1 µM 0.418590010504849 0.335547842354459 no 1102 0.337757895734259 1680 1745025
SGTC_1606 st000094 49.2 µM 0.417690605333689 0.335893750224175 no 1103 0.338086670990075 1743 1242210
SGTC_2750 bromebric acid 70.15 µM 0.415874143049992 0.336592778618276 no 1104 0.338751050586672 1645 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2677 mitomycin C 100 µM 0.412296488191427 0.337971216648678 no 1105 0.340061061173778 1613 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2018 5133068 143 µM 0.412156196740416 0.33802531411921 no 1106 0.340112470430032 1584 785362
SGTC_46 0329-0187a 2.197 µM 0.412144658974298 0.338029763320105 no 1107 0.340116698531827 1678 46494817
SGTC_1422 4031-0024 15.5 µM 0.411642933140061 0.338223261039641 no 1108 0.340300579205031 1631 782427
SGTC_2665 lovastatin 100 µM 0.411192286396427 0.338397095814598 no 1109 0.340465771958346 1599 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1507 4075-3230 155 µM 0.409744177876707 0.338955929618699 no 1110 0.340996809555963 1620 659771
SGTC_706 4262-0057 46.9 µM 0.409599839328895 0.339011650186532 no 1111 0.341049757405359 1563 883298
SGTC_2899 9053889 58.44 µM 0.409068347977321 0.33921685788465 no 1112 0.341244751872164 1687 6470052
SGTC_2996 9066192 71.4286 µM 0.408330477338245 0.339501827264318 no 1113 0.341515533411095 1521 6472854
SGTC_1814 st052110 31.539 µM 0.407799186540748 0.339707071314866 no 1114 0.341710555439046 1714 674163
SGTC_3125 9127534 49.47 µM 0.406175623423772 0.340334567726999 no 1115 0.342306781844073 1586 1639235
SGTC_487 nimodipine 119 µM 0.404131377053904 0.341125284452376 no 1116 0.343058056360234 1687 4497 L-type voltage-gated calcium channels inhibitor
SGTC_193 1273-0060 1.558 µM 0.403492021981748 0.34137273119132 no 1117 0.343293151310619 1601 2847393 YHR072W ERG7
SGTC_249 wiskostatin 11.211 µM 0.401819025556513 0.342020546069917 no 1118 0.343908609613317 1706 2775510 A n-wasp and actin depolymerizer.
SGTC_2728 chlorpromazine 9.18 µM 0.401105207432056 0.342297091272684 no 1119 0.344171333530363 1651 2726 A thorazine and dopamine antagonist.
SGTC_2990 9074105 71.4286 µM 0.400337762754745 0.342594506667216 no 1120 0.344453878857306 1626 6502001
SGTC_2892 9047358 58.44 µM 0.40020253167241 0.342646924221041 no 1121 0.34450367504391 1605 6466771
SGTC_513 4245-1575 41.7 µM 0.400175970451358 0.342657220096509 no 1122 0.344513456007887 1714 719745
SGTC_690 glyoxal 20.3 µM 0.39937333864836 0.342968397834417 no 1123 0.344809067965141 1604 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2036 5160441 105 µM 0.398271891734292 0.343395598614516 no 1124 0.345214888754224 1661 134534 YIL048W NEO1
SGTC_168 3970-0862 530.542 µM 0.397402454612909 0.343732954816646 no 1125 0.34553535285097 1645 3135186
SGTC_2541 muurolladie-3-one 83.07 µM 0.397070749672272 0.343861694722619 no 1126 0.345657644510631 1661 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_27 0485-0001 32.618 µM 0.396377145198432 0.344130952029621 no 1127 0.345913411895945 1672 2054479
SGTC_15 0266-0086 27.098 µM 0.395819796119452 0.344347372267694 no 1128 0.346118985926072 1701 1712902 YIL048W NEO1
SGTC_2102 5377816 72.7585 µM 0.393493453806576 0.345251247360223 no 1129 0.34697752899 1764 1379702
SGTC_1071 trifluoperazine 6.31 µM 0.39303560460549 0.34542924390738 no 1130 0.34714659222881 1730 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2699 st077704 54.6 µM 0.392896824111351 0.345483203903206 no 1131 0.347197843670562 1634 645852
SGTC_1797 st048695 56.8 µM 0.392602937425023 0.345597481942725 no 1132 0.347306384835537 1729 592262 YIL048W NEO1
SGTC_2576 guaiol 23.12 µM 0.392165621625426 0.345767558539431 no 1133 0.34746792185455 1805 227829
SGTC_2275 7947463 200 µM 0.391734086855467 0.345935417350477 no 1134 0.347627350618693 1670 1225414
SGTC_1426 4048-4480 71.7 µM 0.389997596087655 0.346611185018397 no 1135 0.348269162257378 1713 14224343
SGTC_1488 4013-0813 75.9 µM 0.388898530962674 0.347039146520219 no 1136 0.348675604460873 1624 2910057
SGTC_1249 0481-0015 10.2 µM 0.388319604705093 0.34726465130412 no 1137 0.348889765458796 1596 4227577
SGTC_590 k048-0076 22.4 µM 0.387990407857847 0.347392904997793 no 1138 0.349011566048915 1724 6832814
SGTC_532 1548-0774 215 µM 0.387477020958522 0.347592953224965 no 1139 0.34920154674956 1760 5932993
SGTC_2339 9000433 200 µM 0.386071971679534 0.348140666818958 no 1140 0.349721683519709 1575 2988954
SGTC_1216 1165-0504 9.65 µM 0.383902254031567 0.348987084212467 no 1141 0.350525447832659 1746 6304004
SGTC_1283 0922-0125 16.4 µM 0.383555319867376 0.349122494751585 no 1142 0.350654030574814 1732 3360884
SGTC_1925 st057770 10.1 µM 0.382592095334758 0.349498547883975 no 1143 0.3510111160735 1543 5989122
SGTC_668 1682-0499 62.6 µM 0.381376105560104 0.349973494238541 no 1144 0.351462094336574 1645 682214
SGTC_1896 st058441 89 µM 0.381345249259172 0.349985549279014 no 1145 0.351473540841735 1608 688759
SGTC_2308 7584454 197.62 µM 0.381327776182521 0.349992375784748 no 1146 0.351480022743296 1753 893577
SGTC_310 1273-0058 1.06 µM 0.38093597924916 0.350145458522252 no 1147 0.351625377068779 1650 2734232
SGTC_394 menadione 8.33 µM 0.380493044913883 0.35031855097248 no 1148 0.351789729192447 1692 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_649 1123-0311 367 µM 0.380327912709102 0.350383090252529 no 1149 0.351851009086333 1719 693629 YIL048W NEO1
SGTC_1247 0448-0043 5.84 µM 0.380054362009949 0.350490012671267 no 1150 0.351952531113364 1649 3089013 YGL099W LSG1
SGTC_952 1185-0122 232 µM 0.379425262707917 0.350735952866856 no 1151 0.352186046835479 1608 678600
SGTC_3216 9129716 49.47 µM 0.378209613341866 0.351211376234806 no 1152 0.35263744227395 1581 8056934
SGTC_1210 3013-0140 750 nM 0.377740720232318 0.35139481602855 no 1153 0.352811607369897 1786 905973
SGTC_3290 9121031 71.43 µM 0.377482300203386 0.351495929599346 no 1154 0.352907607785278 1622 17014854
SGTC_427 1354-0053 47.3 µM 0.377468473216258 0.351501340064648 no 1155 0.352912744634524 1743 6813657
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.375334404859785 0.352336755703486 no 1156 0.35370589097561 1637 91467 include heat shock
SGTC_2907 7721985 69.9 µM 0.375130816788291 0.352416490867186 no 1157 0.353781589631475 1616 3267881
SGTC_2916 7875993 68.79 µM 0.37335441061929 0.353112494301381 no 1158 0.354442342690392 1825 1299250
SGTC_2155 5570423 76 µM 0.372767702394221 0.353342477188222 no 1159 0.354660671409645 1664 797402
SGTC_1936 st074407 74.3 µM 0.372555213601644 0.35342578357163 no 1160 0.354739755556068 1619 809813
SGTC_3079 9117512 49.47 µM 0.371411719172335 0.353874211871205 no 1161 0.355165449102173 1730 7185044
SGTC_200 k038-0079 37.545 µM 0.371269887732396 0.353929846082416 no 1162 0.355218261912428 1696 3436683
SGTC_129 0088-0017 176.636 µM 0.370782492697825 0.354121053401784 no 1163 0.355399771085887 1766 182446
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.370455611410365 0.354249311051109 no 1164 0.355521522246147 1674 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2240 6690706 185.951 µM 0.369521061771244 0.354616089281907 no 1165 0.355869688635085 1576 805876
SGTC_21 0849-0113 22.993 µM 0.36840831453662 0.355052979707327 no 1166 0.356284399337445 1637 1560156
SGTC_567 1080-0542 68.4 µM 0.3677668563474 0.355304917762512 no 1167 0.356523542223296 1759 5950415
SGTC_1056 3448-1962 115 µM 0.367277000902041 0.355497355177927 no 1168 0.356706203887516 1705 715507
SGTC_2816 7982706 58.44 µM 0.366583835540855 0.35576972488649 no 1169 0.356964733714132 1661 2981853
SGTC_352 k048-0007 5.11 µM 0.364944440461169 0.356414195282687 no 1170 0.357576440014763 1677 6811911
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.36117720739369 0.357896702200248 no 1171 0.358983489812161 1670 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_888 0916-0002 6.97 µM 0.360457022861229 0.358180359070376 no 1172 0.359252695150235 1762 2802138 YIL048W NEO1
SGTC_2051 5263410 176 µM 0.359899882963306 0.358399851774738 no 1173 0.359461002278368 1725 227584
SGTC_1879 gemcitabine 100 µM 0.359333663385789 0.358622969483811 no 1174 0.359672746975997 1727 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1871 st057448 67.3 µM 0.35902938488488 0.358742889768546 no 1175 0.359786553424263 1767 691747
SGTC_2485 5633444 17.78 µM 0.358635855620144 0.358898005641638 no 1176 0.359933759940311 1631 5724239
SGTC_2954 9074818 52.69 µM 0.357759589294286 0.359243483638746 no 1177 0.360261617322819 1746 16648742
SGTC_3018 9082602 49.47 µM 0.357361503485762 0.359400471557535 no 1178 0.360410596160999 1693 17332089
SGTC_676 falcarinol 140 µM 0.355977522070002 0.359946438848577 no 1179 0.360928699404737 1816 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2978 9011784 42.97 µM 0.355740268620978 0.360040061773921 no 1180 0.361017542573176 1871 2994934
SGTC_1227 3909-8010 46.6 µM 0.355207376718688 0.360250377616198 no 1181 0.361217119394358 1697 15982272
SGTC_1195 1502-0147 41.1 µM 0.353646264407711 0.36086674329826 no 1182 0.361801999020314 1668 817940
SGTC_2513 baicalein 25.65 µM 0.352530217466791 0.361307607908595 no 1183 0.362220330433225 1606 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1654 st012436 41.8 µM 0.351612898914062 0.361670108152726 no 1184 0.362564295135594 1781 4323132
SGTC_1385 3091-4834 14.1 µM 0.351561513684954 0.361690417923998 no 1185 0.362583566214015 1762 4072814
SGTC_2078 5212016 200 µM 0.3515449142875 0.361696978841405 no 1186 0.362589791584974 1809 1899708
SGTC_1086 cerivastatin 2.18 µM 0.350933890367295 0.361938514528958 no 1187 0.362818972795268 1750 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2607 solasodine 47.35 µM 0.350114756987353 0.362262401457166 no 1188 0.363126288237499 1654 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_605 1315-0399 119 µM 0.34810593296727 0.363057111492499 no 1189 0.363880314401643 1760 24020461
SGTC_778 3456-2434 196 µM 0.347510281919501 0.363292870323174 no 1190 0.364103997703237 1854 5539063
SGTC_3089 9117425 49.47 µM 0.347459415056056 0.363313005842017 no 1191 0.3641231017523 1643 9401657
SGTC_315 k915-0449 187 µM 0.345576195771357 0.364058738837215 no 1192 0.364830619007981 1763 20970215 YNL149C PGA2
SGTC_2440 5628896 157.78 µM 0.345540988836411 0.3640726852884 no 1193 0.36484385049243 1713 5522048
SGTC_70 0141-0289 43.283 µM 0.345121133505634 0.364239015592167 no 1194 0.365001653093377 1783 352408
SGTC_3036 9090181 49.47 µM 0.34408634516853 0.364649067490747 no 1195 0.365390675809636 1728 25236586
SGTC_721 1187-1332 279 µM 0.343133909818326 0.3650266225842 no 1196 0.365748860842516 1671 25730
SGTC_2806 7952793 58.44 µM 0.342178125062345 0.365405637008303 no 1197 0.366108423192394 1737 2972490
SGTC_79 0052-0007 94.094 µM 0.340379575674693 0.366119204195862 no 1198 0.36678534884236 1806 2801472
SGTC_2922 7999257 32.47 µM 0.340282803477236 0.366157611328881 no 1199 0.366821783066037 1687 2988377
SGTC_2004 4023728 41.89 µM 0.339378286922765 0.366516662367997 no 1200 0.367162386770321 1836 360084 YDR527W RBA50
SGTC_480 am 92016 50 µM 0.339367679519651 0.366520873707947 no 1201 0.36716638170257 1688 2129 K+ channel blocker.
SGTC_3274 9138298 49.47 µM 0.338881859663663 0.366713770609279 no 1202 0.367349365304505 1701 17015756
SGTC_733 4069-0007 56.1 µM 0.338780131790195 0.366754166371382 no 1203 0.367387684830581 1755 5717425 YNL287W SEC21
SGTC_3085 9117376 49.47 µM 0.338606085259608 0.366823283026749 no 1204 0.367453248887661 1755 16480349
SGTC_1933 st074711 15.9 µM 0.337531226894022 0.367250222032559 no 1205 0.367858238085596 1690 17250958
SGTC_1224 0823-0416 294 µM 0.336901285380981 0.367500514228933 no 1206 0.368095658157878 1796 3598164
SGTC_2889 9059656 51.95 µM 0.335955872453246 0.367876257065996 no 1207 0.368452071500474 1782 3949838
SGTC_768 0384-0033 77.3 µM 0.335724250941049 0.367968331512109 no 1208 0.368539408292513 1678 3965305 YMR134W ERG29
SGTC_2446 5162541 200 µM 0.334784255703831 0.368342077301929 no 1209 0.368893918994824 1681 1549321
SGTC_1107 amlodipine 47 µM 0.334658345918617 0.368392148997501 no 1210 0.36894141321161 1694 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2164 5685496 200 µM 0.333725961125536 0.368763008492634 no 1211 0.369293178737662 1802 759046
SGTC_1834 st055981 52.8 µM 0.333681696395583 0.368780617994681 no 1212 0.369309881440291 1838 471719 YDL150W RPC53
SGTC_736 0958-0254 92.6 µM 0.333653426162777 0.368791864671313 no 1213 0.369320548962871 1766 6812352
SGTC_3299 9121982 43.1275 µM 0.333506242864668 0.368850420053093 no 1214 0.369376088905501 1690 17594604 YPL160W CDC60
SGTC_661 1304-0007 33.6 µM 0.333452308541116 0.368871878038774 no 1215 0.369396441824246 1693 3117130
SGTC_2197 6588183 93.1375 µM 0.331410644820802 0.369684462137632 no 1216 0.370167162694938 1758 884136
SGTC_293 4049-0273 38.5 µM 0.329078718076391 0.370613283469303 no 1217 0.371048094858747 1736 1380311
SGTC_3256 9138902 49.47 µM 0.328755836935733 0.370741948691999 no 1218 0.371170123092861 1814 17228773
SGTC_2021 4019055 173 µM 0.32874277741192 0.370747153098736 no 1219 0.371175059022712 1758 44827708 YER133W GLC7
SGTC_2742 clothiapine 36.27 µM 0.327809551906635 0.371119117962224 no 1220 0.371527832338252 1839 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1460 k062-0059 9.15 µM 0.327041548958414 0.371425318804733 no 1221 0.371818230011674 1671 1373085
SGTC_1553 gossypol 38.6 µM 0.32688617353245 0.371487276500508 no 1222 0.371876989525299 1738 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_109 0132-0036 33.701 µM 0.326603735676771 0.371599910293596 no 1223 0.371983808852626 1807 67274 A color developer.
SGTC_1540 guanosine 70.6 µM 0.32660206024902 0.371600578472615 no 1224 0.371984442536701 1827 6802 Guanosine is a purine nucleoside
SGTC_2947 9072639 7.68 µM 0.326006026536245 0.371838307809223 no 1225 0.372209897748007 1673 16488146
SGTC_180 1486-1293 102.781 µM 0.32572373250405 0.371950918456372 no 1226 0.372316693345005 1908 4140536
SGTC_887 0885-0007 9.62 µM 0.325213838409413 0.372154349394516 no 1227 0.372509617964209 1815 5719458
SGTC_1240 0356-0016 42.1 µM 0.324247834302749 0.37253985100266 no 1228 0.372875205029437 1770 4305613
SGTC_8 0354-0001 70 µM 0.323351555935174 0.372897641523265 no 1229 0.373214506619599 1755 4993152
SGTC_1150 3909-7983 10.9 µM 0.322801470477975 0.373117287633051 no 1230 0.373422799648628 1716 23965914
SGTC_1945 st075991 56.6 µM 0.32279243330606 0.373120896470846 no 1231 0.373426221934855 1698 1084980
SGTC_190 3970-0790 3.722 µM 0.32269624111686 0.373159309842302 no 1232 0.373462649569271 1825 2832352
SGTC_1401 3807-4679 7.6 µM 0.321274523340636 0.373727205205237 no 1233 0.374001180653782 1731 3291456
SGTC_2037 5169046 200 µM 0.320214191847825 0.374150925938233 no 1234 0.374402982810734 1791 5718022
SGTC_667 1498-1044 59 µM 0.319775262806808 0.37432637159939 no 1235 0.374569350595597 1767 6739982
SGTC_2898 9056270 58.44 µM 0.317680467665687 0.375164046481681 no 1236 0.375363664413168 1763 19154699
SGTC_2512 diallyl trisulfide 49.23 µM 0.316940096370581 0.375460250158674 no 1237 0.375644528352169 1766 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2456 5770359 74.46 µM 0.315172944805787 0.376167538954543 no 1238 0.37631517321506 1840 3118787
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.31504107051247 0.376220337337889 no 1239 0.376365235323255 1860 16725076
SGTC_2669 eugenol 100 µM 0.314879990543281 0.37628483191232 no 1240 0.37642638730947 1858 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_127 0180-0333 59.125 µM 0.314745996142871 0.376338484367474 no 1241 0.376477258963178 1814 771601
SGTC_1061 3448-9325 110 µM 0.314026540703857 0.376626601052061 no 1242 0.376750440535891 1850 723482
SGTC_1429 4049-0205 9.46 µM 0.313930769085426 0.37666495941568 no 1243 0.376786810255556 1777 22774478
SGTC_1147 3809-1045 12.3 µM 0.313818251214122 0.376710026529329 no 1244 0.376829540840007 1743 325925
SGTC_2442 5158906 48.48 µM 0.31236158473213 0.377293620910262 no 1245 0.377382870863666 1848 1893835
SGTC_460 trequinsin 123 µM 0.312275580666674 0.377328086092104 no 1246 0.377415548292369 1788 5537 A vasodilator.
SGTC_195 4234-0266 16.654 µM 0.311667246215271 0.377571897305564 no 1247 0.377646711314874 1766 2303354
SGTC_1794 st048918 76.9 µM 0.311525809181787 0.377628590115973 no 1248 0.377700462724539 1878 672303
SGTC_330 1488-0319 80.1 µM 0.31027483611854 0.378130137648007 no 1249 0.378175982695318 1789 6846614
SGTC_3185 9108267 49.47 µM 0.309790648762808 0.378324316105864 no 1250 0.378360081618239 1700 4910486
SGTC_3150 9097574 49.47 µM 0.309072109174499 0.378612535797076 no 1251 0.378633337420407 1881 17217476
SGTC_568 1193-0097 7.48 µM 0.307767475672926 0.379136021263666 no 1252 0.379129635869202 1811 3646150
SGTC_2286 7945697 125 µM 0.307167340549493 0.379376900583926 no 1253 0.379358001544971 1694 1245733
SGTC_2683 piperine 63.03 µM 0.306690207872841 0.379568443203019 no 1254 0.379539591912462 1783 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3009 9080819 71.4286 µM 0.306287131869117 0.379730279162044 no 1255 0.379693018001633 1751 17027216
SGTC_2858 9025781 8.96 µM 0.306175511720821 0.379775098639065 no 1256 0.379735508234263 1874 4894980 YPL153C RAD53
SGTC_216 k038-0035 28.382 µM 0.305706060498477 0.379963617749856 no 1257 0.379914229242484 1854 4444231 YPR107C YTH1
SGTC_1531 st059297 52.4 µM 0.304742001200882 0.380350847692616 no 1258 0.380281328908944 1800 7566702
SGTC_1024 4507-0395 26 µM 0.30236187078061 0.381307378251373 no 1259 0.381188108967311 1783 4201836
SGTC_2322 7413319 38.22 µM 0.301910266404529 0.381488951795969 no 1260 0.381360234642465 1785 1840400
SGTC_2974 9094440 9.66 µM 0.299132990368271 0.382606164628433 no 1261 0.382419287686478 1863 25236134
SGTC_446 go6976 132 µM 0.297968589022837 0.383074858945399 no 1262 0.382863568797788 1905 3501 A protein kinase C inhibitor.
SGTC_1161 k007-0610 110 µM 0.297346346508197 0.38332539397335 no 1263 0.383101050690583 1856 5843850
SGTC_1229 0139-0193 12.2 µM 0.297013296291047 0.383459510855352 no 1264 0.383228178991547 1895 3090752
SGTC_2540 epiandrosterone 100 µM 0.296273963693927 0.383757284565257 no 1265 0.383510433904109 1794 441302 A steroid.
SGTC_2519 cryptotanshinone 88.04 µM 0.295762401846438 0.383963361490955 no 1266 0.383705769008286 1869 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1073 triclabendazole 3.09 µM 0.295557391256491 0.384045956910613 no 1267 0.383784058682063 1796 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2253 7938677 135.83 µM 0.295393581224102 0.384111957083887 no 1268 0.383846618050548 1907 2301972
SGTC_2146 5545642 200 µM 0.292416741567489 0.385311929647926 no 1269 0.384984004710601 1852 825326
SGTC_2182 6325192 200 µM 0.291347139485129 0.385743358258435 no 1270 0.385392919118389 1887 736248
SGTC_2049 5262831 67.185 µM 0.291263411895546 0.385777136116137 no 1271 0.385424933993196 1786 763417
SGTC_2242 6630449 61.2675 µM 0.29045586450462 0.386102965878361 no 1272 0.385733755517625 1835 691249 YDR170C SEC7
SGTC_2387 9077560 195.08 µM 0.29017492960742 0.386216336529526 no 1273 0.385841207374994 1770 5303272
SGTC_926 2268-1401 59.4 µM 0.289926300396682 0.386316678397431 no 1274 0.385936310274484 1780 2931578
SGTC_2044 5102272 200 µM 0.288232914369036 0.387000297672881 no 1275 0.386584227673586 1789 592666
SGTC_2766 oltipraz 83.91 µM 0.286595035466973 0.387661842419169 no 1276 0.387211208085437 1892 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1696 st025591 34.7925 µM 0.286588365815373 0.387664536981944 no 1277 0.387213761832431 1808 2787147
SGTC_419 nsc-638432 893 µM 0.285570260923163 0.388075918324402 no 1278 0.387603641820828 1796 368090
SGTC_3350 9150499 3.57 µM 0.28517952173411 0.3882338360423 no 1279 0.38775330425937 1797 4910996 YPR165W RHO1
SGTC_2168 5727979 200 µM 0.284684996841333 0.388433725370581 no 1280 0.38794274300881 1797 695210
SGTC_1511 0906-3109 28.5 µM 0.284191889897462 0.388633070981696 no 1281 0.388131665138636 1788 2882180
SGTC_1104 tacrolimus 29.8 µM 0.283776047648647 0.388801204023371 no 1282 0.388291005729426 1827 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2158 5657123 3.6195 µM 0.282154520661519 0.389457017365982 no 1283 0.388912514646748 1882 2858827
SGTC_1956 st077085 54 µM 0.281133712682808 0.389870036480983 no 1284 0.389303922238543 1776 24208685
SGTC_808 0711-0032 135 µM 0.280005273447537 0.390326747955662 no 1285 0.38973672951804 1936 4252555
SGTC_1281 0884-0031 11.8 µM 0.279597786929112 0.390491706585545 no 1286 0.389893052593274 1766 1548255
SGTC_210 3551-0445 56.827 µM 0.279344368880425 0.390594305185576 no 1287 0.389990279735555 1866 2865180 YOR207C RET1
SGTC_2850 9015429 58.44 µM 0.277307867925377 0.391419077123641 no 1288 0.390771859327158 1775 6457570
SGTC_236 1509-0011 5.31 µM 0.27654876358437 0.391726635458209 no 1289 0.391063305705544 1896 3107280
SGTC_798 1287-0182 476 µM 0.275752511423651 0.392049317315954 no 1290 0.391369080166837 1947 1649755
SGTC_986 1493-0483 84 µM 0.27525409970688 0.392251336886521 no 1291 0.391560512979149 1938 40079
SGTC_910 3454-3003 490 µM 0.274925303937043 0.392384622490307 no 1292 0.391686813112887 1946 820824
SGTC_562 3772-2733 112 µM 0.274280391724532 0.392646090468288 no 1293 0.391934576025567 1923 2876874 YIL048W NEO1
SGTC_1898 st060199 18.6 µM 0.27410745254654 0.392716213770671 no 1294 0.392001023400007 1778 688866
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.273520709847965 0.392954151882172 no 1295 0.392226487460395 1905 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1509 1326-1131 80 µM 0.273506116620396 0.392960070293026 no 1296 0.392232095573002 1927 768313
SGTC_1674 st016616 23.6 µM 0.273311820763977 0.393038871031339 no 1297 0.392306764741084 1712 625830
SGTC_390 dec-rvkr-cmk 16.7 µM 0.271840448580989 0.393635758780993 no 1298 0.392872351221313 1867 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2798 7813637 45.45 µM 0.269902043923001 0.394422487849609 no 1299 0.393617807345457 1865 956368
SGTC_1859 st055998 20 µM 0.268015587935288 0.395188546575343 no 1300 0.39434366005579 1981 676301
SGTC_1058 3448-5425 97.3 µM 0.266979181459314 0.395609586867566 no 1301 0.394742595135847 1926 7279705
SGTC_3300 9124615 50.48 µM 0.266537351155042 0.395789117574796 no 1302 0.394912698683301 1894 24824903
SGTC_2139 5578692 56.4705 µM 0.26607330123249 0.395977700676886 no 1303 0.39509137829677 1958 650991 YMR113W FOL3
SGTC_761 k216-0224 480 µM 0.264806116383163 0.39649278997393 no 1304 0.395579412430738 2003 1340404
SGTC_2657 nystatin 74.44 µM 0.26265944603632 0.39736578722841 no 1305 0.396406538432109 1893 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3181 9108277 49.47 µM 0.262321756378014 0.39750316411882 no 1306 0.396536695001737 1812 17097298
SGTC_1556 plumbagin 1.48 µM 0.261970442478723 0.397646097035082 no 1307 0.396672115033834 1928 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_854 0422-0053 192 µM 0.261041320329825 0.398024178829673 no 1308 0.397030321300636 1836 3596728
SGTC_379 3970-0972 5.9 µM 0.260454006331464 0.398263220226749 no 1309 0.397256794446999 1868 2898042 YBL034C STU1
SGTC_1057 3448-5381 134 µM 0.257899702019759 0.399303285151346 no 1310 0.398242157419061 1941 5497911
SGTC_2893 9048488 25.97 µM 0.257730448906847 0.399372227196112 no 1311 0.398307472467668 1765 6467338
SGTC_122 0236-0016 402.397 µM 0.257487420090363 0.399471225861946 no 1312 0.398401262661351 1852 6808838
SGTC_1442 4112-3290 3 µM 0.256102267280308 0.400035596095633 no 1313 0.398935935659149 1878 704353
SGTC_1019 4262-0212 3.4 µM 0.254436805258993 0.400714452678569 no 1314 0.399579059912026 1992 4677213
SGTC_818 4072-2707 53.5 µM 0.253603238620538 0.401054334348906 no 1315 0.399901047179607 1818 882871
SGTC_2103 5378138 10 µM 0.253224917177172 0.401208617317478 no 1316 0.40004720636334 1904 244142
SGTC_1867 st057372 64 µM 0.25252187868472 0.401495363786654 no 1317 0.400318852598758 1906 688837
SGTC_2174 5790901 200 µM 0.251277616391038 0.402002987735857 no 1318 0.400799739814094 1860 786020
SGTC_1946 st076057 65.1 µM 0.250545819358477 0.402301617580571 no 1319 0.401082637782904 1853 953009
SGTC_2536 dehydroabietamide 32.04 µM 0.25052174733473 0.402311441799694 no 1320 0.401091944423653 1964 3983547
SGTC_150 3970-0969 77.2 µM 0.250287694290811 0.402406966206977 no 1321 0.401182436109341 1886 6615640
SGTC_2809 7964133 12.99 µM 0.249190044910463 0.402855029101403 no 1322 0.401606889802237 1867 1253665
SGTC_2317 5986382 200 µM 0.248329319860829 0.40320646826018 no 1323 0.401939807685603 1948 877883
SGTC_1989 st071868 50.2 µM 0.248159463122039 0.403275831024275 no 1324 0.402005514602205 1988 16414057
SGTC_2911 7942208 15.64 µM 0.247964055403215 0.403355631560713 no 1325 0.402081109015982 1832 1243384
SGTC_1015 4130-4525 82 µM 0.247551701048774 0.403524041891833 no 1326 0.402240642294038 1807 1363237
SGTC_2462 5162487 171.77 µM 0.24681116567606 0.40382653007695 no 1327 0.402527184406887 1991 2259986
SGTC_962 1254-0300 21.5 µM 0.246765975054538 0.403844991058124 no 1328 0.402544672123809 1861 7340576
SGTC_1254 0550-0035 264 µM 0.245752524408402 0.404259055567809 no 1329 0.402936905059026 1938 15121435
SGTC_1425 4048-4433 7.33 µM 0.24511294914525 0.404520421431035 no 1330 0.403184488371482 1954 23734946
SGTC_312 4092-0653 6.84 µM 0.244983081714794 0.404573497661916 no 1331 0.403234765554971 1951 1148278
SGTC_3100 9120536 49.47 µM 0.244543028024435 0.404753358663864 no 1332 0.403405140867727 1998 16421196
SGTC_1539 benzyladenosine 56 µM 0.244418775822547 0.404804147306519 no 1333 0.403453250836024 1870 92208 A nucleotide analog.
SGTC_2009 4012297 12.05 µM 0.243861287771023 0.405032042766761 no 1334 0.403669126011195 1843 45595307
SGTC_1215 3852-0577 11.2 µM 0.242367752968489 0.405642743177356 no 1335 0.404247609488173 1970 2884876
SGTC_2082 5219693 150 µM 0.240611813884391 0.406361033393762 no 1336 0.404927996500134 1865 2834649
SGTC_1525 8-methoxypsoralen 92.5 µM 0.239959174882012 0.406628084536045 no 1337 0.405180952873771 2025 4114 Related to psoralen; DNA damaging agent.
SGTC_1168 k815-0004 80.5 µM 0.239095802965955 0.406981431475634 no 1338 0.405515648079484 1874 642433
SGTC_1222 0366-0074 1.18 µM 0.237810663807037 0.407507532686756 no 1339 0.406013973698091 1992 286520
SGTC_1457 k015-0032 57.3 µM 0.237444515367074 0.407657454539761 no 1340 0.406155979348824 1863 4302660
SGTC_2251 lansoprazole 556 µM 0.237442363508726 0.407658335672112 no 1341 0.406156813954083 1812 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_844 0330-0132 15.3 µM 0.237136118216755 0.407783740246841 no 1342 0.406275596533679 1971 2828079
SGTC_836 0330-0104 1.35 µM 0.2365340614283 0.408030304390876 no 1343 0.406509139903183 1914 46494820
SGTC_2364 9055074 200 µM 0.235141811057512 0.408600620888533 no 1344 0.407049333891801 1844 6470630
SGTC_937 3122-0005 46.7 µM 0.234206215333565 0.40898398384654 no 1345 0.407412445028971 2007 759535
SGTC_651 3253-0966 34.4 µM 0.234185903834039 0.408992307507225 no 1346 0.407420328945284 1887 781462
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.234165106960253 0.409000830117 no 1347 0.407428401298657 1999 1241132 A phosphatase inhibitor.
SGTC_1740 st038286 13.222 µM 0.233787805377095 0.409155456695577 no 1348 0.407574858580314 1923 716786
SGTC_1344 1488-0097 29.1 µM 0.232655334462793 0.409619653260492 no 1349 0.408014527698643 1911 747966
SGTC_378 3970-0959 8.33 µM 0.23181065296374 0.409965968322791 no 1350 0.408342541271796 1922 6615653
SGTC_3035 9091303 49.47 µM 0.231725994185706 0.410000681862795 no 1351 0.40837542020057 1911 25237002
SGTC_3032 9089427 49.47 µM 0.231532713176988 0.410079937575419 no 1352 0.408450487160948 1880 17173707
SGTC_1943 st076331 65.2 µM 0.231430161255722 0.410121990925564 no 1353 0.408490317896239 2042 24208415
SGTC_3014 9081533 49.47 µM 0.23140388513646 0.410132766110388 no 1354 0.408500523582701 2018 21367265
SGTC_2499 avocadenofuran 51.48 µM 0.230521717379153 0.410494560558053 no 1355 0.408843194913065 1799 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_222 nsc-310342 10.666 µM 0.229983463641317 0.410715346504308 no 1356 0.409052309718257 2008 432556
SGTC_2229 7354935 190 µM 0.229930612499703 0.410737027005859 no 1357 0.409072844100424 1973 318112
SGTC_181 1447-1644 8.07 µM 0.228460021236726 0.411340399486952 no 1358 0.409644316366295 2011 534600
SGTC_3215 9129942 49.47 µM 0.228432325502427 0.411351764854314 no 1359 0.409655080784073 2047 17682944
SGTC_2471 5466956 24.79 µM 0.226741982833586 0.412045563253706 no 1360 0.4103121898085 1941 724419
SGTC_3335 9143315 29.6265 µM 0.225969148489413 0.4123628635962 no 1361 0.410612707836422 1874 4899691
SGTC_2062 5245942 200 µM 0.225308905358295 0.412633983078741 no 1362 0.410869486148054 1993 1376160
SGTC_2163 5671233 125 µM 0.224982152145185 0.412768175082489 no 1363 0.410996579439361 2005 701023
SGTC_3258 9138477 49.47 µM 0.223886962278524 0.413218025255664 no 1364 0.411422630417257 1930 4970355
SGTC_2781 5567276 71.43 µM 0.223800729937459 0.413253450110711 no 1365 0.411456180983016 1955 2853274
SGTC_1856 st057054 55.7 µM 0.222694092447817 0.413708127201347 no 1366 0.41188679973097 2030 1266018
SGTC_2259 7964009 200 µM 0.222596734995533 0.413748133383929 no 1367 0.411924688898597 1971 313134
SGTC_1590 st077108 57.8 µM 0.222588312939361 0.413751594222372 no 1368 0.41192796659792 2015 5489485
SGTC_3008 9078912 71.4286 µM 0.221528310940742 0.414187229570783 no 1369 0.412340547597011 1873 16648731
SGTC_1843 st055809 45.5 µM 0.221086237324097 0.414368942438397 no 1370 0.412512643074755 1906 16413835
SGTC_3121 9125696 49.47 µM 0.220367835549094 0.414664278143284 no 1371 0.412792346605033 2062 1235365
SGTC_2623 humulene 100 µM 0.220147760847882 0.414754760739167 no 1372 0.412878039657626 1875 6187145 An anti-inflammatory.
SGTC_663 1486-0733 13.9 µM 0.219251139253182 0.415123448856527 no 1373 0.413227210536714 1918 722445 YPR165W RHO1
SGTC_632 0781-2353 4.65 µM 0.219169842993459 0.415156881336571 no 1374 0.413258873095009 1957 6811515 YHR007C ERG11
SGTC_3053 9095903 49.47 µM 0.218951485373364 0.415246682318636 no 1375 0.413343919908808 2032 17174018
SGTC_3126 9127922 49.47 µM 0.218511270753094 0.415427736881806 no 1376 0.413515388847133 1948 45595682
SGTC_2940 9060638 45.86 µM 0.217827168546572 0.415709134870637 no 1377 0.413781887682961 1910 4027022
SGTC_1921 5740136 50 µM 0.217572798461826 0.415813778266349 no 1378 0.413880990221403 2063 1774243
SGTC_1358 1509-0022 2.48 µM 0.217434902658526 0.415870508679301 no 1379 0.413934716694156 1954 3258434
SGTC_3242 9133940 49.47 µM 0.216901691985893 0.416089888343533 no 1380 0.41414247949016 1984 17248444
SGTC_2277 7947813 106.88 µM 0.21661980991632 0.416205874074242 no 1381 0.414252323101877 2012 1246798
SGTC_3051 9093778 49.47 µM 0.216195799040044 0.416380355143236 no 1382 0.41441756399991 2030 17217378
SGTC_1716 st033144 30.6155 µM 0.215832061304428 0.416530046863373 no 1383 0.414559327978753 2035 674617
SGTC_1660 st012960 28.1 µM 0.215709508665438 0.416580484598188 no 1384 0.41460709443276 1923 24207266
SGTC_2748 diazoxide 86.69 µM 0.215559239093442 0.416642331381736 no 1385 0.41466566563826 1992 3019 A potassium channel activatior.
SGTC_475 α-linolenic acid 10 µM 0.214530698266113 0.417065705547783 no 1386 0.415066615208651 2028 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3182 9108849 49.47 µM 0.213972308326708 0.417295593693497 no 1387 0.415284325912633 1941 17133045
SGTC_1779 st039427 55 µM 0.213474493773594 0.417500566903471 no 1388 0.41547844080942 2092 1124498
SGTC_1888 azatryptophan 97.5 µM 0.212416875307784 0.417936111545832 no 1389 0.415890910785998 1922 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3005 9076496 71.4286 µM 0.212071680154961 0.418078290392268 no 1390 0.416025556577382 2052 21368410
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.21159206239313 0.418275852939643 no 1391 0.416212651209684 1947 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1374 2889-5571 141 µM 0.211332581501081 0.418382746041377 no 1392 0.416313880320673 1901 2853281
SGTC_204 PMA1.184 62.41 µM 0.210867807018472 0.418574224859922 no 1393 0.416495212776048 1958 2252213 YGL008C PMA1
SGTC_40 0327-0103 19.753 µM 0.210726259523427 0.418632543744817 no 1394 0.416550441273938 1889 409036
SGTC_2265 7929201 200 µM 0.209883174299796 0.418979939707509 no 1395 0.416879427357297 1883 1265108
SGTC_1767 st044992 70.3 µM 0.208488203125076 0.419554880675232 no 1396 0.41742389640415 1898 9600693
SGTC_1090 efavirenz 20.7 µM 0.207787168957063 0.419843878647048 no 1397 0.417697575825598 1973 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_25 0118-0223 35.662 µM 0.207255631327723 0.420063031309305 no 1398 0.417905111423981 2023 5333628
SGTC_2560 caryophyllene 100 µM 0.207159412424487 0.420102704960022 no 1399 0.417942681948687 1946 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2013 4024628 200 µM 0.206936150458699 0.420194765021108 no 1400 0.41802986176932 1972 5230760
SGTC_1919 st067113 52.3 µM 0.206197259112311 0.420499471323953 no 1401 0.418318414379078 1928 1268243
SGTC_2582 agaric acid 100 µM 0.205155325370272 0.420929228112305 no 1402 0.418725386094551 1905 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3175 9106517 49.47 µM 0.204827911697111 0.421064292890472 no 1403 0.418853289471031 1922 41468073
SGTC_842 0271-0008 11.1 µM 0.204491918132507 0.421202906706682 no 1404 0.418984553479729 1995 1221709
SGTC_2381 9035592 200 µM 0.20376623851253 0.421502318429968 no 1405 0.41926808852389 1879 4749657
SGTC_1490 4089-0339 670 nM 0.20237333917655 0.422077148656905 no 1406 0.41981243471583 2050 742542
SGTC_3341 9147222 25.867 µM 0.201751347357748 0.422333889749109 no 1407 0.420055559249342 1954 1939759
SGTC_9 0092-0002 10.449 µM 0.198374493698779 0.423728335183202 no 1408 0.421376035979274 2009 759368
SGTC_2143 5623677 140.463 µM 0.198128787029235 0.423829835347243 no 1409 0.421472151233109 2044 5375313
SGTC_1060 3448-7350 82 µM 0.197760639200276 0.423981924782233 no 1410 0.421616171635567 2055 570178
SGTC_525 k781-2675 26.7 µM 0.197322849758875 0.424162799335452 no 1411 0.421787449667884 2092 3651118 YDL195W SEC31
SGTC_3233 9132340 49.47 µM 0.197283403674319 0.424179097436666 no 1412 0.421802883037085 1921 17682950
SGTC_705 1124-0212 310 µM 0.197279323792095 0.424180783145808 no 1413 0.421804479307024 2062 9554485
SGTC_1907 st060210 83.7 µM 0.197045663187601 0.424277328397495 no 1414 0.42189590207907 2043 688793
SGTC_556 4058-0063 51.5 µM 0.196414270589137 0.424538233587736 no 1415 0.422142963744858 1934 6615692
SGTC_1270 0831-1170 17.3 µM 0.19596088714124 0.424725601919408 no 1416 0.422320389972977 2020 6764716
SGTC_33 0986-0033 35.816 µM 0.194633030572703 0.425274458674293 no 1417 0.422840121437415 2059 2848082
SGTC_3346 9158254 43.5805 µM 0.192905684317526 0.425988657288111 no 1418 0.42351641660449 1972 17639500
SGTC_1682 st012968 530 nM 0.192609536489056 0.426111128739685 no 1419 0.42363238787185 1889 24207270
SGTC_1496 4469-0713 57.4 µM 0.188735327664548 0.427713953654124 no 1420 0.425150130842513 2061 746691
SGTC_2857 9024691 58.44 µM 0.188714681755695 0.42772249843243 no 1421 0.425158221986142 1951 16478292
SGTC_2625 euphol 100 µM 0.188683156107293 0.427735546103459 no 1422 0.425170576966817 2086 6708538 A triterpene alcohol.
SGTC_173 1273-0061 2.693 µM 0.187340264468556 0.428291408294776 no 1423 0.42569692765597 1899 2847414 YPL266W DIM1
SGTC_3135 9127742 49.47 µM 0.18717745677273 0.428358808863992 no 1424 0.425760749674536 1930 3643468
SGTC_2136 5328288 199.296 µM 0.18714215657998 0.42837342302561 no 1425 0.42577458791066 1950 262395
SGTC_3278 9139605 49.47 µM 0.186444517196101 0.428662263523229 no 1426 0.426048092362527 2051 7958859
SGTC_2464 5717415 7.67 µM 0.18600712444664 0.428843374776507 no 1427 0.426219587165466 1888 5285744
SGTC_3276 9139060 49.47 µM 0.185677873025934 0.428979717827512 no 1428 0.426348690664511 1997 4870619
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.185299932625541 0.429136233436802 no 1429 0.426496895435727 2126 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2092 5303694 80.6725 µM 0.182331938892305 0.430365747434035 no 1430 0.427661117580233 1943 1963699
SGTC_1979 st071809 45.3 µM 0.181551754402638 0.430689057392919 no 1431 0.427967256945838 2051 4976333
SGTC_1410 3909-8106 77.9 µM 0.180208219710663 0.431245929543481 no 1432 0.428494552839483 2092 1039210
SGTC_2755 lomerizine 42.69 µM 0.179170855485738 0.43167599285217 no 1433 0.428901773676117 1956 3949 A calcium channel blocker.
SGTC_361 000s-0510 1.45 µM 0.178771422456139 0.431841608669431 no 1434 0.429058592671041 1987 660
SGTC_3154 9100113 49.47 µM 0.178720028621258 0.431862918824177 no 1435 0.429078770908514 1950 25237525
SGTC_2198 6589944 200 µM 0.17704263837269 0.432558547423667 no 1436 0.429737448983609 2049 5290268
SGTC_1904 st060225 78 µM 0.175441772281859 0.433222635810171 no 1437 0.430366260008638 2066 66595
SGTC_1742 st038235 28.8875 µM 0.17251172826124 0.43443859520325 no 1438 0.431517620883405 1984 564103 YBR002C RER2
SGTC_570 0987-0065 62.6 µM 0.172386410499235 0.434490615613251 no 1439 0.431566877550606 2114 3104428
SGTC_1363 1636-0063 10.4 µM 0.172006918383914 0.434648152754238 no 1440 0.431716044990917 1990 6072185
SGTC_1199 1638-0010 4.46 µM 0.171435357888569 0.434885442098811 no 1441 0.431940727359626 1938 3111136
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.17046246628816 0.435289402164156 no 1442 0.432323224941604 2033 676296 Flavone; oxidizing agent.
SGTC_2075 5212009 200 µM 0.169717922718683 0.435598594141816 no 1443 0.432615989133579 2092 780898
SGTC_323 4013-0906 34.3 µM 0.16939675261038 0.435731980934953 no 1444 0.432742288818216 2114 2910086
SGTC_1393 3470-5649 58.2 µM 0.169136492322374 0.435840076324126 no 1445 0.432844640844271 2012 4108395
SGTC_974 1326-0144 138 µM 0.16743864448242 0.436545370418289 no 1446 0.433512460224948 1964 5411856
SGTC_1992 st073643 23.3 µM 0.166229209510846 0.437047898670343 no 1447 0.433988286677291 2063 3161292
SGTC_1966 st070145 16.1 µM 0.16545495323179 0.437369660676729 no 1448 0.434292951604444 2049 3748532
SGTC_1075 aripiprazole 15.2 µM 0.164780081822091 0.437650154556887 no 1449 0.434558541060867 2000 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.164464550422996 0.437781308263999 no 1450 0.43468272569064 2104 165506
SGTC_497 capsazepine 133 µM 0.163636074607538 0.438125704826796 no 1451 0.435008822021819 1916 2733484 A calcium channel blocker.
SGTC_1968 st069590 43.6 µM 0.163193487909252 0.438309706895279 no 1452 0.435183046685521 2106 6384066
SGTC_2 0422-0095 29 µM 0.162853882071974 0.438450904495629 no 1453 0.435316741372396 2043 6790840
SGTC_1341 1486-1360 280 µM 0.161605398459087 0.43897005256487 no 1454 0.435808302921915 1971 3976547
SGTC_3060 1327-0027 12.5 µM 0.161184042544838 0.439145285744406 no 1455 0.435974224492481 2133 16000455 YPR107C YTH1
SGTC_1448 4255-0083 152 µM 0.160406303306823 0.439468762650972 no 1456 0.436280512296757 2096 5399660
SGTC_1443 4112-3303 14 µM 0.160065894187078 0.439610358168659 no 1457 0.4364145836099 2041 704433
SGTC_961 1252-1571 372 µM 0.159897148651249 0.439680551901677 no 1458 0.436481047334035 2121 6813498
SGTC_80 0159-0065 512.242 µM 0.159758701567923 0.439738143686514 no 1459 0.436535578760396 2134 1548079
SGTC_1937 st074714 47.2 µM 0.159580733682276 0.439812177369724 no 1460 0.436605678380344 1944 17250970
SGTC_1887 st057648 70.8 µM 0.158666213477195 0.440192645997384 no 1461 0.436965929324108 2138 688672
SGTC_2261 9010538 184.68 µM 0.158043984124331 0.440451544205159 no 1462 0.437211069953084 1971 6457250
SGTC_3266 9136860 49.47 µM 0.156482967792455 0.441101166248566 no 1463 0.437826171794714 2074 4871271 YPR165W RHO1
SGTC_1303 1160-0052 261 µM 0.154847105677415 0.441782105676542 no 1464 0.438470927045098 2146 3562476
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.152602498418234 0.44271671934318 no 1465 0.439355877313106 2036 6708784 An antioxidant flavonoid
SGTC_604 1000-0114 314 µM 0.151578852704931 0.443143052994823 no 1466 0.439759556875148 2129 1572745
SGTC_2813 7971799 71.43 µM 0.151479013008832 0.443184638317397 no 1467 0.439798932494177 2038 2234054
SGTC_2883 9059145 45.46 µM 0.150704273477683 0.443507354778648 no 1468 0.440104500996618 2051 16476510
SGTC_486 niguldipine 82 µM 0.150382295172473 0.443641485340165 no 1469 0.440231504413476 2065 1236 A calcium channel blocker.
SGTC_2846 9008642 19.48 µM 0.150288401263002 0.443680601126383 no 1470 0.440268541754857 2003 2992898
SGTC_2060 5238662 140 µM 0.148847326382913 0.44428101514317 no 1471 0.440837052758106 2024 790130
SGTC_1307 1187-1599 12.2 µM 0.148389860734028 0.444471641893912 no 1472 0.441017550724751 2022 1538471
SGTC_1575 cyproterone acetate 48 µM 0.146956967318827 0.445068814060028 no 1473 0.44158299328148 2004 9880 An androgen receptor antagonist and liver toxin.
SGTC_2033 5192550 145 µM 0.14677752032602 0.445143609139522 no 1474 0.441653814335627 2027 182073
SGTC_3223 9129970 49.47 µM 0.144641053326229 0.44603425661073 no 1475 0.442497141089723 2069 17248386
SGTC_3333 9141820 12.094 µM 0.143925752526695 0.44633251132274 no 1476 0.442779549912883 2029 1939433
SGTC_1944 st076371 56.9 µM 0.143392094346584 0.446555047381364 no 1477 0.442990263126942 1968 24208455
SGTC_2966 9084041 48.03 µM 0.143245927203393 0.446616002183203 no 1478 0.443047979568375 1889 17741380
SGTC_1302 1159-0335 255 µM 0.142492651181736 0.446930154244962 no 1479 0.44334544182546 2037 649284
SGTC_3139 9095020 49.47 µM 0.142026552815641 0.44712455620662 no 1480 0.44352951608463 2167 25236292
SGTC_1474 0330-0125 5.35 µM 0.141495183775656 0.447346196988532 no 1481 0.443739382278121 2136 X1474
SGTC_1238 0333-0287 48.8 µM 0.141240479138496 0.447452443365272 no 1482 0.443839984427238 2075 7226
SGTC_1018 4259-0013 28.1 µM 0.140040349780387 0.447953110685364 no 1483 0.444314054988137 2050 6801262
SGTC_1704 st028805 70.8 µM 0.138931866826417 0.448415618848949 no 1484 0.444751994535338 2050 2876101
SGTC_3061 glucosamine 200 µM 0.138453250741931 0.448615340380946 no 1485 0.444941107101662 2171 91431 and experimental redox chemotherapeutic
SGTC_2276 7947513 42.08 µM 0.137766283344397 0.448902027505167 no 1486 0.44521256610529 1900 2105100
SGTC_226 1,3-diallylurea 8.28947 mM 0.137666375162464 0.448943723688405 no 1487 0.445252047524293 2114 74537 YKL182W FAS1
SGTC_637 1181-0519 7.26 µM 0.137647034616167 0.44895179543445 no 1488 0.445259690526761 2131 6252091 YGR060W ERG25
SGTC_1624 st003710 6.25 µM 0.137098120926188 0.449180892481194 no 1489 0.445476618864446 2144 24207033
SGTC_3186 9110464 49.47 µM 0.136271508088043 0.449525923218598 no 1490 0.445803323498461 2147 17018021
SGTC_1223 0764-0573 147 µM 0.135774860581774 0.449733243783519 no 1491 0.445999632672488 2122 1609797
SGTC_3187 9109394 49.47 µM 0.135572309245465 0.449817800767874 no 1492 0.446079698662624 2034 17098090
SGTC_1626 st003712 1.76 µM 0.13481529362378 0.450133844288816 no 1493 0.446378956834198 2105 24207035
SGTC_1331 1472-0049 76.2 µM 0.134724668916751 0.450171680970546 no 1494 0.446414784015979 2046 24051409
SGTC_846 0335-0850 148 µM 0.134327498106432 0.450337508919217 no 1495 0.446571804970953 2170 6819598
SGTC_85 0868-0259 160.055 µM 0.133158282681487 0.450825733478904 no 1496 0.4470341012843 2097 83173
SGTC_269 exalamide 29 µM 0.132644580079427 0.451040261770332 no 1497 0.447237237052337 2069 3316 A derivative of salicylamide.
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.132640108503454 0.451042129216303 no 1498 0.447239005328909 2168 88881 An O-methylated flavonoid and antioxidant.
SGTC_445 e6 berbamine 66 µM 0.131929466130124 0.45133892562522 no 1499 0.447520040865425 2081 6610268 A calcium/calmodulin antagonist.
SGTC_1155 4088-0394 48.2 µM 0.131482434840488 0.451525640067837 no 1500 0.447696840453669 2013 2326248
SGTC_1495 4469-0029 237 µM 0.131107347711216 0.451682313404805 no 1501 0.447845194352918 2144 793680
SGTC_3010 9080089 71.4286 µM 0.130553786340122 0.451913548910077 no 1502 0.448064151439696 2177 17027233
SGTC_1561 5-methoxyflavone 52.9 µM 0.130206539102438 0.45205861051801 no 1503 0.44820151058513 2186 94525
SGTC_1760 st045453 10.4495 µM 0.129425370095924 0.452384965153954 no 1504 0.448510537036007 2182 3323419 YIL048W NEO1
SGTC_3158 9100007 49.47 µM 0.128290345288639 0.452859209967202 no 1505 0.44895960265714 2062 19297233
SGTC_133 0724-0033 378.92 µM 0.127915652863492 0.453015781642118 no 1506 0.449107861807974 2190 280309
SGTC_2300 7976697 71.57 µM 0.127760726223572 0.453080522539499 no 1507 0.449169165610872 2051 2236109
SGTC_304 1310-0298 97 µM 0.127593569109365 0.453150375718238 no 1508 0.449235310320529 2097 1550234
SGTC_1178 0988-0033 191 µM 0.126943668940685 0.453421975836514 no 1509 0.449492491692432 2120 5392207
SGTC_3120 9124077 49.47 µM 0.126688913965601 0.45352844657223 no 1510 0.449593310253819 2206 18774327 YGL155W CDC43
SGTC_544 k015-0020 52.4 µM 0.126475931422727 0.45361746175715 no 1511 0.449677599990841 2084 3008304
SGTC_1642 st009582 77.7 µM 0.125730943902876 0.453928844553877 no 1512 0.449972453269431 2191 6739311
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.125264196392475 0.454123945680652 no 1513 0.450157198009023 1976 641818 YHR062C RPP1
SGTC_1285 0929-0069 65.5 µM 0.124833489999066 0.454303991391021 no 1514 0.450327686789137 2072 1206237
SGTC_2460 5552655 174.22 µM 0.123090128861631 0.455032854139496 no 1515 0.451017863932452 2055 5401989
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.122547707831069 0.455259659999334 no 1516 0.451232632650779 2130 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_914 3820-6779 408 µM 0.120343376403984 0.456181520020028 no 1517 0.452105572185282 2145 2893481
SGTC_3200 9114385 49.47 µM 0.119079067924588 0.456710365551413 no 1518 0.452606357055386 2071 17018030 YLR208W SEC13
SGTC_3132 9126706 49.47 µM 0.118973555049174 0.456754503839672 no 1519 0.452648153480916 2126 850858
SGTC_908 3448-7491 47.7 µM 0.114395783434688 0.458669989809864 no 1520 0.454462028193124 2122 1203031
SGTC_1014 4130-3005 69.3 µM 0.113109517289904 0.4592083793803 no 1521 0.454971864855675 2066 743608
SGTC_845 0330-0138 4.51 µM 0.112683405117346 0.459386752756108 no 1522 0.45514077912115 2211 9039800
SGTC_3323 9138564 53.9225 µM 0.112245446337417 0.459570093719892 no 1523 0.455314397928144 2204 43912313 YNL103W MET4
SGTC_2045 5106652 78.05 µM 0.11152890564106 0.45987007486084 no 1524 0.455598472596421 2195 673349
SGTC_1822 st052468 42 µM 0.111237196974291 0.459992205808505 no 1525 0.455714127866738 2156 2873678
SGTC_523 1934-0222 13.7 µM 0.11079478845767 0.460177438123833 no 1526 0.455889539058397 2085 1361595
SGTC_607 4491-0986 66.8 µM 0.109717577840926 0.460628492213989 no 1527 0.456316679739467 2197 698981 YDR232W HEM1
SGTC_3211 9128781 49.47 µM 0.108834328773398 0.46099836774817 no 1528 0.456666947554681 1959 17194361
SGTC_1881 5652484 16 µM 0.108241560865429 0.461246618309464 no 1529 0.456902038900859 2218 2255129
SGTC_2379 9035213 200 µM 0.106701473479356 0.461891675598426 no 1530 0.45751290680743 2248 646551
SGTC_1105 epirubicin 18.1 µM 0.106579724632048 0.461942673744141 no 1531 0.457561202175251 2072 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2797 7859098 81.82 µM 0.106484849949857 0.461982415275921 no 1532 0.457598837526002 2153 972681
SGTC_3297 9117502 71.43 µM 0.105360864417055 0.462453264146666 no 1533 0.458044734420977 2263 7453720
SGTC_851 0394-0702 453 µM 0.105163522162333 0.462535938255394 no 1534 0.458123027636768 2227 762646
SGTC_301 4119-0100 24.5 µM 0.103538883662243 0.463216621741826 no 1535 0.458767645305749 2135 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2065 5221596 34.26 µM 0.10349629786624 0.463234465598008 no 1536 0.458784543796131 2177 788581
SGTC_2912 7964298 10.93 µM 0.102693000960208 0.463571068509194 no 1537 0.459103314350417 2122 2975850
SGTC_68 0986-0284 82.829 µM 0.102581583215293 0.463617757592416 no 1538 0.459147530091744 1931 423278 YIL048W NEO1
SGTC_3239 9133757 49.47 µM 0.102566240344483 0.463624186989705 no 1539 0.459153618895817 2188 17036923
SGTC_1371 2421-0008 32.7 µM 0.100761808912877 0.464380395941482 no 1540 0.459869772281896 2126 2827552
SGTC_45 0kpi-0036 14.9 µM 0.100660550264945 0.464422835693659 no 1541 0.45990996429149 2149 2795021
SGTC_3020 9089140 49.47 µM 0.0996541040106337 0.46484468163815 no 1542 0.460309469389052 2141 17217859
SGTC_355 1311-2252 105 µM 0.0994425525901972 0.464933357196035 no 1543 0.460393449048633 2106 5338538
SGTC_2767 sibutramine 71.45 µM 0.0994143779136425 0.46494516724665 no 1544 0.460404633695662 2222 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2041 5107442 45.335 µM 0.0972383555891899 0.465857388538427 no 1545 0.461268554498768 2222 793005
SGTC_2374 9071832 200 µM 0.0970964722333118 0.465916874458167 no 1546 0.461324891187928 2225 17381698
SGTC_2948 9070189 9.45 µM 0.0963061244739932 0.466248249023281 no 1547 0.461638723536234 2251 6473636 YDL196W YDL196W
SGTC_571 k831-0106 44.2 µM 0.0953795755042549 0.466636759390813 no 1548 0.462006669247769 2245 4783639
SGTC_982 1491-0518 27.5 µM 0.0950427930116346 0.466777983234997 no 1549 0.46214041841732 2150 3091256
SGTC_1196 1588-0294 184 µM 0.0950392303305355 0.466779477205353 no 1550 0.462141833316743 2124 6144269
SGTC_802 4112-3352 742 µM 0.0947820749942403 0.466887313645913 no 1551 0.462243962424148 2208 704594
SGTC_2820 7989630 71.43 µM 0.0947500840215029 0.466900729025257 no 1552 0.462256667796487 2247 2984098
SGTC_2596 sinensetin 100 µM 0.0941892329107486 0.467135927418158 no 1553 0.462479418821104 2153 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2636 apigenin dimethyl ether 100 µM 0.0937194905598961 0.467332927296289 no 1554 0.462665993596905 2169 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1102 cgs 12066b 26.1 µM 0.0930926888923605 0.467595806940759 no 1555 0.462914962816475 2153 6438352 A 5-HT1B full agonist.
SGTC_1844 rapamycin 4 nM 0.0929266868160775 0.467665430325173 no 1556 0.462980902231129 2123 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_693 4161-2696 114 µM 0.0922038187902542 0.467968621883604 no 1557 0.463268052008153 2196 805759
SGTC_3265 9137266 49.47 µM 0.0921601372096933 0.467986943786976 no 1558 0.46328540455389 2273 17224265
SGTC_3243 9134147 49.47 µM 0.0920800044769547 0.468020555022364 no 1559 0.463317237533016 2256 24282180
SGTC_2972 9093619 59.92 µM 0.0913211907699184 0.468338846538623 no 1560 0.463618690270273 2059 25236256
SGTC_1895 st058434 18.3 µM 0.0904192137462677 0.468717215560517 no 1561 0.463977044434673 2260 5393175
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0898580702815516 0.468952623091342 no 1562 0.46420000068594 2133 4174840
SGTC_1451 4152-0210 104 µM 0.0889368029660903 0.469339131115307 no 1563 0.464566067445456 2239 659563
SGTC_197 4544-0043 41.561 µM 0.0887135071159745 0.46943281690779 no 1564 0.464654798868176 2252 896523
SGTC_2511 berberine 10.47 µM 0.0886069041296239 0.469477543751541 no 1565 0.464697160484472 2203 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0883064100475692 0.469603622514532 no 1566 0.464816572190082 2233 5106787 A p450 inhibitor.
SGTC_2441 5730946 39.09 µM 0.0881181741379493 0.469682602497264 no 1567 0.464891375847196 2197 1774275
SGTC_206 4546-0025 72.014 µM 0.0877841258121036 0.469822765357231 no 1568 0.465024127409717 2141 6620745 YIL048W NEO1
SGTC_140 0062-0056 502.533 µM 0.0876512700457436 0.4698785111588 no 1569 0.465076925675498 2256 3758964
SGTC_163 TUB2.036 7.546 µM 0.087571413155671 0.46991201910672 no 1570 0.465108661931557 2269 15992207 YJR013W GPI14
SGTC_1332 1480-0653 17.5 µM 0.087537788750089 0.469926127969732 no 1571 0.465122024811675 2271 5749438
SGTC_441 propafenone 146 µM 0.0875254577058971 0.469931302108233 no 1572 0.46512692537702 2250 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1735 st034310 56.75 µM 0.0862106165126529 0.470483041880667 no 1573 0.465649495686871 2172 871153
SGTC_2867 9039098 71.43 µM 0.0847763238733007 0.471084971013962 no 1574 0.466219608288134 2272 6463460
SGTC_3113 9123498 49.47 µM 0.0844979323820752 0.471201811180571 no 1575 0.46633027334201 2272 8897275
SGTC_716 1683-5115 658 µM 0.0836616436071865 0.471552814217212 no 1576 0.466662727077966 2278 723597
SGTC_2274 7947094 46.08 µM 0.0830904270842513 0.47179257514188 no 1577 0.466889818802561 2278 2971028
SGTC_866 0495-0101 262 µM 0.0825944518231779 0.472000762791404 no 1578 0.467087006503221 2058 635694
SGTC_2792 7535235 81.82 µM 0.0825559727802807 0.472016914847958 no 1579 0.46710230517307 2153 1281891
SGTC_1792 st045773 43.6 µM 0.0800981780430013 0.47304869893921 no 1580 0.468079585902307 2154 2919270
SGTC_3316 9136639 10.545 µM 0.07984299386114 0.473155835933825 no 1581 0.468181064648865 2194 4903665
SGTC_1133 3473-0247 50 µM 0.0798073194565183 0.473170813696137 no 1582 0.468195251405714 2056 711311
SGTC_2266 7929956 200 µM 0.0793417267902626 0.473366294466176 no 1583 0.468380408856896 2280 2967153
SGTC_1726 st035556 14.5795 µM 0.0787285822795722 0.473623735190868 no 1584 0.468624255331527 2247 5919439
SGTC_2733 amorolfine 100 µM 0.0784588362568021 0.473736996834272 no 1585 0.46873153657589 2280 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_47 0149-0135 24.25 µM 0.0784416622077983 0.473744207989459 no 1586 0.468738366979132 2271 5239155
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0778376114197772 0.473997846352252 no 1587 0.468978613803754 2255 16486 A toxic proline analog.
SGTC_1505 k297-0037 20.6 µM 0.0770186662697283 0.474341734758975 no 1588 0.469304347768918 2147 4089396
SGTC_1074 carmofur 3.8 µM 0.076424617573836 0.47459119746066 no 1589 0.469540642442406 2277 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_266 formosanin C 406 nM 0.076294357421554 0.474645899782015 no 1590 0.46959245744344 2266 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2294 7971431 200 µM 0.0746069944086656 0.475354545142965 no 1591 0.470263704451465 2237 5741572
SGTC_2944 9067346 25.62 µM 0.0744925146325193 0.475402626302706 no 1592 0.470309248538978 2225 6473075
SGTC_117 lucigenin 22.078 µM 0.0743463272773915 0.47546402507038 no 1593 0.470367407582889 2054 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_675 1309-0189 238 µM 0.0740156435029961 0.475602914580634 no 1594 0.47049896884403 2187 4246530
SGTC_3235 9132602 49.47 µM 0.0722658494785167 0.476337889317814 no 1595 0.471195170890736 2198 4912240
SGTC_131 0141-0277 33.849 µM 0.0705021061803432 0.477078804705982 no 1596 0.471897012117044 2260 1547771
SGTC_2147 5545932 89.7195 µM 0.0696296563870625 0.477445333908534 no 1597 0.472244215918034 2202 797404
SGTC_1821 st053465 65.6 µM 0.0691303318072242 0.477655116234939 no 1598 0.472442938742027 2212 675086
SGTC_96 0929-0093 37.281 µM 0.0691049515388324 0.477665779468388 no 1599 0.472453039847592 2157 6991579
SGTC_918 glabranin 770.725 nM 0.0690074826637918 0.47770673006523 no 1600 0.472491831697961 2225 124049 Also referred to as licorice root.
SGTC_1931 st074438 57.1 µM 0.0660223089962055 0.47896103359324 no 1601 0.473680032095906 2290 2787313
SGTC_612 0302-0167 22.4 µM 0.0659428335693225 0.478994430301512 no 1602 0.473711669259566 2256 235821
SGTC_3082 9117008 49.47 µM 0.063157497312026 0.480164959812731 no 1603 0.474820544703002 2181 41448529
SGTC_2095 5432005 200 µM 0.0629740290174731 0.480242067948409 no 1604 0.474893592551915 2280 783734
SGTC_680 0417-1641 114 µM 0.0625750276190556 0.480409762980361 no 1605 0.475052457754661 2250 2835990
SGTC_3116 9124943 49.47 µM 0.062442154228714 0.480465608687073 no 1606 0.475105363107763 2239 41905195 YPL160W CDC60
SGTC_3308 9128332 17.569 µM 0.0616741417551157 0.480788406148046 no 1607 0.475411166323766 2286 17332805 YDL196W YDL196W
SGTC_2566 crystal violet carbinol 226 nM 0.0609848137220083 0.48107814308639 no 1608 0.475685651718481 2100 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2321 7390090 138.78 µM 0.0609184996328467 0.481106016617175 no 1609 0.475712058115581 2209 649046
SGTC_776 4476-4378 112 µM 0.0598949225226799 0.481536264245075 no 1610 0.476119661938287 2166 2892008
SGTC_1877 wortmannin 25 µM 0.0585754744487089 0.482090909131243 no 1611 0.47664512284369 2304 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2752 diclazuril 33.15 µM 0.057192699039574 0.48267221155975 no 1612 0.477195846982435 2283 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_387 norethindrone acetate 66.7 µM 0.0570993953106105 0.482711436684473 no 1613 0.47723300905571 2235 541197
SGTC_1959 st077091 55.8 µM 0.0559335064742362 0.483201593301309 no 1614 0.477697389147626 2303 821356 YKL052C ASK1
SGTC_342 k048-0088 23.3 µM 0.0540974277790858 0.483973558666948 no 1615 0.478428770791744 2309 6820570
SGTC_1799 st045822 46.1415 µM 0.0535313392616126 0.484211578543114 no 1616 0.47865428065936 2310 3674992
SGTC_2845 9003024 42.97 µM 0.0533772995473062 0.484276347684056 no 1617 0.478715645880146 2279 2990173
SGTC_2929 9013348 24.6 µM 0.051385293857551 0.485113963882829 no 1618 0.479509251546678 2273 2995952
SGTC_1384 3089-0840 101 µM 0.0505336450164461 0.485472092992297 no 1619 0.479848569399296 2307 1069836
SGTC_2011 4012611 177 µM 0.0504663879275284 0.48550037595189 no 1620 0.479875366903732 2282 2049887
SGTC_1600 coumarin 106 71.1 µM 0.0487866229938827 0.486206774206884 no 1621 0.480544671392439 2283 100336 A hepatotoxic, DNA x-linker.
SGTC_3077 9117319 49.47 µM 0.048133542318234 0.486481428638461 no 1622 0.480804907136225 2337 17154678
SGTC_1982 st072467 71.9 µM 0.0470679857260013 0.486929564379229 no 1623 0.48122952136795 2204 3163533
SGTC_2323 6148992 148.28 µM 0.0461832096310484 0.487301682748143 no 1624 0.48158211248397 2278 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2686 alizarin 95.37 µM 0.0461482182234924 0.487316399633631 no 1625 0.481596057168008 2276 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_451 chloral hydrate 100 µM 0.0444626876505076 0.488025329763861 no 1626 0.482267796744186 2273 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_130 0136-0219 337.655 µM 0.0439662578656933 0.488234134258484 no 1627 0.482465650084334 2342 234244
SGTC_1897 st060201 15 µM 0.041659606179249 0.489204381822452 no 1628 0.483385027792987 2225 611878
SGTC_2421 5690543 90.72 µM 0.0414677881535889 0.48928506925031 no 1629 0.483461486042541 2267 3397993
SGTC_399 oxolinic acid 75 µM 0.039198832391297 0.490239528105527 no 1630 0.484365932269685 2253 4628 A DNA gyrase inhibitor.
SGTC_453 enantio-paf c16 10 µM 0.0389638972227618 0.4903383592123 no 1631 0.484459586292655 2325 13871343 A lipid and platelet activating factor
SGTC_115 0527-0192 112.043 µM 0.0385756115271207 0.49050170218943 no 1632 0.484614373498976 2219 4233931
SGTC_1833 st055984 71 µM 0.0383714948654076 0.490587570075596 no 1633 0.484695744020131 2279 676288
SGTC_1139 k015-0024 46.9 µM 0.0381723958726729 0.490671327546888 no 1634 0.484775114875991 2344 2766652
SGTC_1652 st011932 78 µM 0.0381305210335533 0.490688943613327 no 1635 0.484791808366408 2338 1551076
SGTC_803 4488-1585 147 µM 0.0379010843729001 0.490785464221014 no 1636 0.484883274233638 2330 747204
SGTC_963 1269-2853 151 µM 0.03756628110969 0.490926311965678 no 1637 0.485016746355634 2304 3668223
SGTC_484 loperamide 105 µM 0.0367495596126356 0.491269901681678 no 1638 0.485342346225804 2336 3955 An opioid-receptor agonist.
SGTC_159 3970-0959 50 µM 0.0363679993860321 0.491430423960365 no 1639 0.485494465041046 2325 6615653
SGTC_1119 parthenolide 318.541 nM 0.0355932019878306 0.491756385248129 no 1640 0.485803364458331 2305 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_320 4092-0846 5.34 µM 0.0350077930824731 0.492002673476564 no 1641 0.486036763351246 2330 1359356
SGTC_208 k072-0098 12.366 µM 0.0346736102051994 0.492143269411874 no 1642 0.486170002137629 2354 5948901
SGTC_1502 4534-4282 27.7 µM 0.0344982624338121 0.492217041338707 no 1643 0.486239913951012 2321 3278949
SGTC_1121 fusaric acid 630.51 nM 0.0342480877829606 0.492322294725112 no 1644 0.486339660253168 2293 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2231 micatex 6.853 µM 0.0341778522423425 0.492351844292155 no 1645 0.486367663785655 2289 20737 An antifungal of unknown mechanism.
SGTC_574 1315-0397 40 µM 0.0340923313784567 0.492387824772372 no 1646 0.486401761802736 2349 6794277
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0338023519976758 0.492509825839469 no 1647 0.48651738019798 2347 756377
SGTC_3000 9075062 71.4286 µM 0.032615552765351 0.493009147047133 no 1648 0.486990583557893 2314 17057871
SGTC_1475 4092-1048 11.7 µM 0.0326115164219407 0.493010845274195 no 1649 0.48699219296979 2264 2881759
SGTC_309 k408-0051 1.48 µM 0.0325041467703898 0.493056019387683 no 1650 0.487035004566979 2317 3640463
SGTC_2109 5483026 200 µM 0.0320865023564424 0.493231737630633 no 1651 0.487201533714068 2310 759335
SGTC_2106 5357045 167.29 µM 0.0317670361112924 0.493366149624211 no 1652 0.487328917367068 2326 668842
SGTC_2455 5377712 9.75 µM 0.0316948567349643 0.493396518426902 no 1653 0.487357698279331 2222 2243908
SGTC_288 1315-0019 35.1 µM 0.0316353491731204 0.493421555710049 no 1654 0.487381426462896 2326 6811474
SGTC_2655 perillic acid 100 µM 0.0307254004361735 0.493804411805561 no 1655 0.487744267052001 2309 5702197 An apoptosis inducer.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0305878647284016 0.493862279728896 no 1656 0.487799110083258 2322 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_765 1319-0117 244 µM 0.0305583960539627 0.493874678642148 no 1657 0.48781086089032 2356 3487746 YGL099W LSG1
SGTC_2068 5226020 147 µM 0.0297177417501723 0.494228385487327 no 1658 0.488146081150044 2346 1810509
SGTC_2071 5230951 39.92 µM 0.0295336472872369 0.494305844186667 no 1659 0.488219491992045 2340 1799272
SGTC_160 3453-0671 289.699 µM 0.0277765448241879 0.495045164539073 no 1660 0.488920186631114 2351 5322268
SGTC_1012 4112-3522 18 µM 0.0268017127493129 0.495455343450809 no 1661 0.489308943566759 2359 3112398
SGTC_2614 arthonioic acid 13.39 µM 0.0266245680436657 0.495529880942686 no 1662 0.489379588869045 2353 6710684
SGTC_792 4534-1957 155 µM 0.0249807852033144 0.496221545463211 no 1663 0.490035145006285 2258 1717904
SGTC_1030 k029-0042 36.7 µM 0.0232374292000535 0.496955120355607 no 1664 0.49073044123825 2255 6080581
SGTC_496 calpeptin 138 µM 0.0222729631937565 0.497360956016195 no 1665 0.491115107888379 2277 73364 A calpain inhibitor.
SGTC_2043 5101342 149 µM 0.0214020154308434 0.49772744268653 no 1666 0.491462482926775 2338 678451
SGTC_2885 9057732 51.95 µM 0.0213630940214703 0.497743820498526 no 1667 0.491478006773323 2332 6471414
SGTC_1291 0993-0025 5.79 µM 0.0209966155857232 0.497898031821491 no 1668 0.491624177726563 2366 4353356
SGTC_2648 atorvastatin 78.68 µM 0.0202442500489698 0.498214622444261 no 1669 0.491924264336881 2364 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1675 st018485 24.5 µM 0.0201976963702282 0.498234211974559 no 1670 0.491942832771047 2283 3323024
SGTC_2992 9074591 71.4286 µM 0.0198901112836844 0.498363642180996 no 1671 0.492065516819278 2372 17741321
SGTC_3114 9122766 49.47 µM 0.0198643869987545 0.498374466834444 no 1672 0.492075777296986 2279 17176985
SGTC_459 nigericin 15.3 µM 0.018401400704157 0.49899008604643 no 1673 0.492659317516151 2349 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0183897255876254 0.498994998903829 no 1674 0.492663974425755 2352 4213774
SGTC_1657 st012939 43.4 µM 0.0167783725215589 0.49967305304322 no 1675 0.493306711848444 2365 24207257
SGTC_2987 9018338 71.43 µM 0.0152244368926982 0.49967305304322 no 1676 0.493926563049496 2376 5055682
SGTC_1173 0443-0020 122 µM 0.0149942356344522 0.499576184711798 no 1677 0.494018389581978 2370 5331295
SGTC_2756 carbadox 75.1 µM 0.0145897473618074 0.499405976739815 no 1678 0.494179739401884 2376 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.014576792732418 0.499400525455589 no 1679 0.494184907001744 2376 2374 Ca(2+)-ATPase inhibitor.
SGTC_1631 benzylvanillin 81.9 µM 0.0144379154248333 0.499342086147168 no 1680 0.494240305201532 2355 75506
SGTC_2787 5284540 71.43 µM 0.0130715133467837 0.498767107686298 no 1681 0.494785369156741 2367 736958
SGTC_2402 5553605 200 µM 0.0129507540721612 0.498716292601539 no 1682 0.494833541059435 2376 6758546
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0128041395154202 0.498654597731635 no 1683 0.49489202695547 2378 17037758
SGTC_2149 5554786 194.827 µM 0.0127976799308226 0.498651879562762 no 1684 0.494894603745751 2368 745063 YPR165W RHO1
SGTC_2370 9071495 200 µM 0.0122494428331782 0.498421183697549 no 1685 0.495113301550037 2304 21791103
SGTC_94 0334-0113 514.748 µM 0.0114181928300996 0.498071398224302 no 1686 0.495444899093155 2378 6795178
SGTC_1732 st034308 51.822 µM 0.0105349586863019 0.497699739738557 no 1687 0.495797237298747 2380 830119
SGTC_517 1365-0151 113 µM 0.010509032075076 0.497688830038237 no 1688 0.495807579947607 2354 768657
SGTC_1076 itraconazole 331 nM 0.0102787558496575 0.497591931812805 no 1689 0.495899441907697 2386 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_271 rotenone 740 µM 0.00982165721839141 0.497399589125514 no 1690 0.496081788667085 2345 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2239 6685329 187.64 µM 0.00649183780178679 0.495998454356563 no 1691 0.497410149614463 2321 805680
SGTC_327 1273-0057 3.96 µM 0.00636353685679516 0.495944468247136 no 1692 0.49746133322866 2394 3108138
SGTC_3169 9102970 49.47 µM 0.00586927293382086 0.495736493971954 no 1693 0.497658512314894 2390 17027839
SGTC_425 3825-7017 13.1 µM 0.00492054280786055 0.495337294632592 no 1694 0.498036995352716 2381 3397440
SGTC_2763 lisinopril 49.32 µM 0.00459749769274925 0.495201367248106 no 1695 0.498165870247645 2401 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_753 1322-0200 289 µM 0.00424043631194739 0.495051127520855 no 1696 0.498308315737597 2398 5403907
SGTC_964 1287-0107 19.4 µM 0.00348103949412776 0.494731600587811 no 1697 0.498611268970735 2398 51516812 YPR165W RHO1
SGTC_1692 fluoroquinolonic acid 71 µM 0.00340141570866346 0.494698097948103 no 1698 0.498643034077192 2382 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_258 haloperidol 50.781 µM 0.0032573921172331 0.494637498431411 no 1699 0.498700490858686 2399 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1940 st075990 51.1 µM 0.00305783908930038 0.494553534495853 no 1700 0.498780100601701 2381 1084979
SGTC_3328 9140624 29.0385 µM 0.00271212415524257 0.494408072047344 no 1701 0.498918020331214 2399 4904392
SGTC_2581 avocatin a 64 µM 0.00213733185745332 0.494166225038301 no 1702 0.499147328604007 2397 6710728 A skin care supplement.
SGTC_3076 9116187 49.47 µM 0.00208690537605175 0.494145007920942 no 1703 0.499167445814616 2399 27241210
SGTC_291 SEC14.278 35.5 µM 0.00145727215281871 0.493880088967205 no 1704 0.499418632729958 2404 1068044
SGTC_2254 7938975 95.19 µM 0.00134744002674164 0.49383387723814 no 1705 0.49946244936569 2404 2969277
SGTC_3093 9117344 49.47 µM 0.00134555637482994 0.493833084694685 no 1706 0.499463200833398 2401 24824913
SGTC_2302 7771753 200 µM 0.00133586675212163 0.493829007802192 no 1707 0.499467066430103 2399 2203047
SGTC_801 0866-0028 10.1 µM -0.000194293318439036 0.493185203887777 no 1708 0.499922488180963 2406 6849771
SGTC_69 0096-0274 206.684 µM -0.000650949860804073 0.492993072274295 no 1709 0.499740308596444 2409 6741392
SGTC_407 eburnamonine 100 µM -0.000992930878501119 0.492849189785743 no 1710 0.49960387795614 2408 3195
SGTC_1042 0350-0096 82 µM -0.00178884987251795 0.492514324525 no 1711 0.499286352533172 2408 3122515
SGTC_1780 st038448 24.544 µM -0.00192500391293986 0.492457041254683 no 1712 0.49923203502349 2413 728868 YDL195W SEC31
SGTC_520 3584-0023 682 µM -0.00272839646078819 0.492119037947459 no 1713 0.498911528644551 2419 1340790
SGTC_953 1188-0045 9.7 µM -0.00282578593834019 0.492078064626851 no 1714 0.498872676014125 2406 6144426
SGTC_3201 9113999 49.47 µM -0.00349322689128204 0.491797263748056 no 1715 0.498606406932284 2422 16649224
SGTC_2603 homopterocarpin 100 µM -0.00349759018420466 0.491795428068575 no 1716 0.498604666240889 2416 101795 A weak amylase inhibitor.
SGTC_112 phenothiazine 287.218 µM -0.00471618294791379 0.491282761263494 no 1717 0.498118522194729 2416 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3136 9095672 49.47 µM -0.00562533936284472 0.490900284889223 no 1718 0.4977558261225 2412 17217380
SGTC_219 mitoxanthrone 164.414 µM -0.00569809851649182 0.490869675928739 no 1719 0.497726799885053 2416 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1386 3228-0095 33.8 µM -0.00592072378376201 0.490776020308603 no 1720 0.497637986752138 2410 870181
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0059414079183873 0.490767318781823 no 1721 0.49762973512144 2414 66535 A nucleotide analog.
SGTC_3099 9120367 49.47 µM -0.00614654605309103 0.490681020269901 no 1722 0.497547898341076 2418 24824940
SGTC_2267 7931562 200 µM -0.00626466093324318 0.490631331323158 no 1723 0.497500778228761 2415 934880
SGTC_572 0960-0087 17.7 µM -0.00888722944440403 0.489528099643603 no 1724 0.496454555090616 2419 6796365
SGTC_1627 st003713 25.6 µM -0.00898061401394358 0.489488817133996 no 1725 0.496417301524228 2427 16195070 YER133W GLC7
SGTC_1067 clotrimazole 1.36 µM -0.00994788527333442 0.489081937537884 no 1726 0.496031433419162 2432 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2341 7987486 176.74 µM -0.0105693505960252 0.488820526083976 no 1727 0.495783517675703 2430 1258686
SGTC_375 3970-0961 9.27 µM -0.0114072528242114 0.488468080832225 no 1728 0.495449263239827 2432 2898222
SGTC_1636 st007707 68.9 µM -0.0114544681280711 0.48844822101245 no 1729 0.495430428289408 2433 403051
SGTC_2696 st077691 74.316 µM -0.0120061525487633 0.488216172260481 no 1730 0.495210353193053 2445 757133
SGTC_3275 9138069 49.47 µM -0.0121103068084035 0.488172363482471 no 1731 0.495168804675923 2474 17617007
SGTC_2553 4-methylesculetin 85.09 µM -0.0130179871839039 0.48779058617425 no 1732 0.494806721189452 2422 5319502
SGTC_2094 5332512 191.667 µM -0.0133681522303815 0.487643307048968 no 1733 0.494667037704986 2437 755774
SGTC_363 0455-0021 3.06 µM -0.0142266809650018 0.487282217754027 no 1734 0.494324566903736 2438 4597466
SGTC_1602 st001878 87.6 µM -0.0142489340767097 0.487272858437115 no 1735 0.494315690096383 2459 595405 YLR310C CDC25
SGTC_998 3996-0085 177 µM -0.0170014845305622 0.48611523368468 no 1736 0.493217715729825 2436 715391
SGTC_1762 st045503 25.4615 µM -0.0172077977741147 0.486028470269623 no 1737 0.493135420693469 2442 4645554
SGTC_469 w7 172 µM -0.0172108676738437 0.486027179252373 no 1738 0.493134196162014 2436 45115570 A P450 inhibitor.
SGTC_2373 9071805 200 µM -0.0172184043498532 0.486024009775295 no 1739 0.493131189908775 2439 10149009
SGTC_1955 wogonin 32.4 µM -0.0176938702748503 0.485824058916999 no 1740 0.49294153534785 2454 5281703 A flavanone.
SGTC_1564 D-Arginine 115 µM -0.0209084408468691 0.484472310135249 no 1741 0.491659346637372 2460 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1547 harmine 94.2 µM -0.0220793877428333 0.483979962521724 no 1742 0.491192314333346 2448 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2072 5231554 129 µM -0.0228288860475879 0.483664834016524 no 1743 0.490893383145783 2461 789545
SGTC_911 3456-4043 236 µM -0.0229782306134378 0.483602042919524 no 1744 0.490833818909116 2471 914281
SGTC_1376 2910-0861 41.3 µM -0.0230371949345078 0.483577251808632 no 1745 0.490810301773688 2457 1112859
SGTC_1252 0493-0875 34.8 µM -0.0234690665589733 0.483395676533082 no 1746 0.490638056497824 2457 3960963
SGTC_409 arachidonic acid 100 µM -0.0251699631104373 0.482680588703163 no 1747 0.489959697664136 2440 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_157 1348-1695 65.819 µM -0.0266997469110661 0.482037487304805 no 1748 0.489349607498585 2462 5380510
SGTC_1198 1612-1005 86.7 µM -0.0278165938299661 0.481568008671919 no 1749 0.488904215560632 2482 6998509
SGTC_337 1315-0038 354 µM -0.0279099134644805 0.481528781906456 no 1750 0.488867000861669 2472 1626437
SGTC_1978 st071761 42 µM -0.0286758150426789 0.481206843142473 no 1751 0.488561572616972 2485 5147680
SGTC_2207 7258803 200 µM -0.0296516610015934 0.480796674224881 no 1752 0.488172431942095 2459 3666799
SGTC_602 3130-1533 38.1 µM -0.0299673710354238 0.480663978880189 no 1753 0.488046537809423 2490 720941
SGTC_1655 st012546 55.1 µM -0.0311225554123814 0.480178464414319 no 1754 0.48758590088145 2505 720985 YLR208W SEC13
SGTC_1251 0490-5699 265 µM -0.0314213484772183 0.480052888911008 no 1755 0.487466757966496 2465 3883818
SGTC_994 3910-0338 138 µM -0.0316149745831616 0.479971513594949 no 1756 0.487389550684536 2505 3479481
SGTC_1653 st012112 65 µM -0.0318203679389073 0.479885193764835 no 1757 0.4873076517969 2483 720429
SGTC_3342 9147791 14.508 µM -0.0328591745231676 0.479448633281181 no 1758 0.48689344460607 2456 1838168
SGTC_740 k014-0057 261 µM -0.0335986628427337 0.479137876869418 no 1759 0.486598594282308 2515 4012779
SGTC_67 0335-0847 266 µM -0.034648858934897 0.478696573049277 no 1760 0.486179870536112 2546 4552207 YOR254C SEC63
SGTC_2397 5161689 200 µM -0.0347907078999103 0.478636968561409 no 1761 0.486123315084622 2488 2259942
SGTC_1487 3970-0795 2.82 µM -0.0348390035327725 0.478616674997711 no 1762 0.486104059587798 2498 3765103
SGTC_10 0279-0212 42.575 µM -0.0352745106533884 0.478433679771545 no 1763 0.485930424115062 2472 39851 YBR002C RER2
SGTC_1757 st041620 31.8375 µM -0.0368145397064773 0.477786613495255 no 1764 0.48531644044913 2496 5289815
SGTC_1289 0976-0073 69.1 µM -0.0370604486367313 0.477683296551664 no 1765 0.485218403882278 2547 3391136
SGTC_2822 7994718 71.43 µM -0.0373841541685606 0.477547296189466 no 1766 0.485089353490409 2464 1018011
SGTC_893 0958-0369 48.9 µM -0.038227977613718 0.477192787875657 no 1767 0.484752957142256 2545 6819948
SGTC_2330 7979373 200 µM -0.0385673319151709 0.477050222933602 no 1768 0.484617674130064 2487 1863007
SGTC_2906 7926292 26.41 µM -0.0396385306433858 0.476600224758104 no 1769 0.484190654276948 2523 2966319
SGTC_1951 sophoraflavanone G 9.2 µM -0.0398731356791108 0.476501673863835 no 1770 0.484097134343782 2475 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1409 3909-8004 61.9 µM -0.0400454140083201 0.476429305558889 no 1771 0.484028460083835 2499 2119279
SGTC_2938 9059746 27.26 µM -0.0411957813431671 0.47594609515421 no 1772 0.483569908410022 2521 6471769
SGTC_832 4083-0019 164 µM -0.0414022478187077 0.475859372884867 no 1773 0.483487610417607 2539 1990758
SGTC_1118 chelidonine 707.474 nM -0.0437238203060195 0.474884320725845 no 1774 0.482562275756369 2489 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_922 1866-0035 480 µM -0.0442149684594632 0.474678059333741 no 1775 0.48236652530839 2492 3156169
SGTC_440 fluspirilene 35.1 µM -0.0460616123193079 0.473902608422508 no 1776 0.48163057122278 2714 3396 An atypical antipsychotic.
SGTC_1183 1254-0324 198 µM -0.0461753495978344 0.473854850560522 no 1777 0.481585244841846 2521 5799357
SGTC_2800 7887935 81.82 µM -0.0464397463648666 0.473743832790509 no 1778 0.48147987882643 2542 2961002
SGTC_2307 7538926 6.34 µM -0.0470408517895658 0.473491441754342 no 1779 0.481240334265282 2523 96582
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0484346629291513 0.472906252019041 no 1780 0.48068491734441 2531 5393153
SGTC_1666 st014829 29 µM -0.0493504113990087 0.472521808002924 no 1781 0.480320022971439 2485 3858230
SGTC_2783 7738165 71.43 µM -0.051499676913748 0.471619617443649 no 1782 0.47946367964846 2532 17201110
SGTC_1038 k292-0204 154 µM -0.0516697419837079 0.471548235909765 no 1783 0.479395923710387 2492 4454212
SGTC_3041 9091929 49.47 µM -0.0553002424382403 0.47002462505869 no 1784 0.477949634512876 2552 25236887
SGTC_1924 st058459 75.1 µM -0.0562888250430801 0.469609822010311 no 1785 0.477555860522521 2500 688683
SGTC_1824 st053723 68.6 µM -0.0566678366519741 0.469450799842426 no 1786 0.477404897730674 2531 675225
SGTC_789 1309-1135 70.6 µM -0.057345955751455 0.469166293109042 no 1787 0.477134806581907 2519 3092424
SGTC_455 paf C-16 10 µM -0.0578195991423337 0.468967584051385 no 1788 0.476946163218201 2503 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1718 roemerine 11.9335 µM -0.0583171453774994 0.468758855286187 no 1789 0.476748005360162 2514 235224 An aporphine alkaloid with mutagenic activity.
SGTC_949 1165-0505 146 µM -0.0583209779649177 0.468757247486474 no 1790 0.476746478976907 2513 6244267
SGTC_1932 st074806 40.9 µM -0.058413231304024 0.468718546659461 no 1791 0.476709737856109 2712 17251235
SGTC_2433 5607874 27.82 µM -0.0592108263805 0.468383963122713 no 1792 0.476392093284382 2513 2252428
SGTC_1081 sertraline 6 µM -0.0594250675028396 0.468294094807551 no 1793 0.476306773678346 2519 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2090 5301565 104.445 µM -0.0594723136440552 0.468274276555517 no 1794 0.476287958472274 2520 2056344
SGTC_1529 apigenin 74 µM -0.0596836044003448 0.468185647772992 no 1795 0.476203815123689 2548 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1878 temozolomide 1 mM -0.0597345422475653 0.46816428143565 no 1796 0.476183530054904 2494 5394 DNA alkylating agent.
SGTC_1892 st058411 7.36 µM -0.0600317877152636 0.468039600986488 no 1797 0.476065158700454 2506 3934738
SGTC_2310 7668677 200 µM -0.0601658464149245 0.467983370712154 no 1798 0.476011773514369 2559 2197143
SGTC_867 0518-0118 155 µM -0.0625014371817937 0.467003821933675 no 1799 0.475081758736933 2532 6848158
SGTC_505 gw-5074 63.9 µM -0.0632243205442822 0.466700684243161 no 1800 0.474793939262382 2611 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1327 1436-0082 2.18 µM -0.0639628228042119 0.466391016789035 no 1801 0.474499914633625 2572 15992205
SGTC_633 0437-0093 97.7 µM -0.0662723123935487 0.465422737872298 no 1802 0.473580513130013 2505 2831118
SGTC_467 ro 31-8220 72.8 µM -0.06668204515469 0.465250974118313 no 1803 0.473417414192175 2546 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1672 st016598 6.51 µM -0.067266728905871 0.465005880513522 no 1804 0.473184681681055 2596 4665860 YNL267W PIK1
SGTC_481 bay k-8644 50 µM -0.0683359926088713 0.464557690224283 no 1805 0.472759086561962 2523 2303 A calcium channel antagonist.
SGTC_2186 6124449 200 µM -0.0687981726153194 0.464363977725426 no 1806 0.472575136342413 2576 3834182 YLR033W RSC58
SGTC_3075 9116269 49.47 µM -0.0688027168255018 0.464362073162373 no 1807 0.472573327750396 2601 17015205 YNL244C SUI1
SGTC_673 1082-0474 110 µM -0.0689910762855472 0.464283128926328 no 1808 0.472498361333922 2526 3098046
SGTC_3279 9140807 49.47 µM -0.0692436848554145 0.464177259145802 no 1809 0.472397825522762 2520 45595718
SGTC_3226 9131256 49.47 µM -0.0693551385158123 0.464130549048134 no 1810 0.472353468583396 2509 17178073
SGTC_3353 9151644 39.2805 µM -0.0701258878443769 0.463807542478844 no 1811 0.472046730949895 2594 4909158
SGTC_279 1273-0055 2.93 µM -0.0701993986601237 0.463776736719218 no 1812 0.472017476473043 2532 2847562
SGTC_1433 4060-0023 7.6 µM -0.0706794988156637 0.463575549225894 no 1813 0.471826418799387 2611 3840627
SGTC_1047 2043-3044 82 µM -0.0714113535958575 0.463268881097854 no 1814 0.471535186908753 2529 669592
SGTC_2345 9052315 157.45 µM -0.0715251767080568 0.46322118790833 no 1815 0.471489893876568 2591 6469265
SGTC_1354 1498-1681 81 µM -0.0715366448351429 0.463216382660848 no 1816 0.471485330445531 2597 5754243
SGTC_3190 9110366 49.47 µM -0.071709390549821 0.463144001316151 no 1817 0.47141659141327 2541 17123768
SGTC_1140 3229-1848 2.98 µM -0.0718279984536466 0.463094304699539 no 1818 0.471369395409623 2527 2849525
SGTC_905 2-aminofluorene 215 µM -0.072020890893049 0.46301348415247 no 1819 0.471292641246539 2547 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1181 1222-0449 220 µM -0.0742090115725065 0.462096784987296 no 1820 0.470422037713316 2615 658318
SGTC_2166 5933061 31.504 µM -0.0749028168677833 0.461806161498212 no 1821 0.470146017659601 2830 2877375
SGTC_3038 9091290 49.47 µM -0.075263175712732 0.461655221213302 no 1822 0.470002659937498 2574 25236843
SGTC_1151 3909-8316 15.3 µM -0.0756626530850825 0.461487902156448 no 1823 0.469843744653031 2637 800431
SGTC_2256 7954252 200 µM -0.07609911816581 0.461305098780252 no 1824 0.469670120855002 2613 2972920
SGTC_1128 3448-9350 235 µM -0.0762828992228261 0.461228128748571 no 1825 0.469597015320734 2646 619386
SGTC_1774 st048371 48.465 µM -0.077227212949937 0.460832660151534 no 1826 0.469221396742279 2550 4242727
SGTC_3259 9138485 49.47 µM -0.0785309466805712 0.460286733993736 no 1827 0.468702857168571 2556 17646153
SGTC_755 1995-0008 37.3 µM -0.0795698447892157 0.459851758784458 no 1828 0.468289689759731 2538 689533
SGTC_1816 st051957 91.6 µM -0.0797094722392019 0.45979330195852 no 1829 0.468234162835049 2541 674121
SGTC_2794 7785382 27.27 µM -0.0804857954636656 0.459468300151038 no 1830 0.467925446580118 2529 2205081
SGTC_2452 5863136 48.41 µM -0.0810293417611007 0.459240764738855 no 1831 0.467709308935371 2539 2184096
SGTC_2336 9001819 198.65 µM -0.0814351317487956 0.45907090457492 no 1832 0.467547955392502 2621 2989602
SGTC_1494 4358-1428 177 µM -0.0816495229840549 0.458981165280868 no 1833 0.467462709542269 2550 1564571
SGTC_1820 st053765 18.6 µM -0.0818686261396989 0.458889455843786 no 1834 0.467375591688679 2617 3690829
SGTC_1765 st044815 90.4 µM -0.0834292285501092 0.45823630213639 no 1835 0.466755124248567 2622 645695
SGTC_2285 7945142 200 µM -0.0844361818550812 0.457814925073338 no 1836 0.466354820513529 2636 2970608
SGTC_1736 st036774 51 µM -0.0859392237282751 0.457186039495711 no 1837 0.465757365404231 2653 1272247
SGTC_863 0466-0191 129 µM -0.0868648713074011 0.456798793867352 no 1838 0.465389461287241 2553 765160 YPR165W RHO1
SGTC_559 1550-0661 158 µM -0.0885413112951109 0.456097558128032 no 1839 0.464723225792617 2631 5830875
SGTC_408 cantharidin 100 µM -0.0902958300015797 0.455363809406223 no 1840 0.464026066896586 2619 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1025 k007-0731 70 µM -0.0909434416441623 0.455093013229819 no 1841 0.463768765874932 2564 6256118
SGTC_281 1672-3440 14.9 µM -0.0913568134933366 0.454920174373053 no 1842 0.463604538017859 2633 6833000
SGTC_1392 3455-1037 33.9 µM -0.0913795477612753 0.45491066897816 no 1843 0.463595506135684 2680 981132
SGTC_110 0850-0284 111.64 µM -0.0930617302224559 0.454207405873291 no 1844 0.462927260155129 2549 3906265
SGTC_253 dyclonine 31.25 µM -0.0934758149347375 0.454034313110733 no 1845 0.462762781221382 2562 3180 An oral anasthetic.
SGTC_477 mead ethanolamide 10 µM -0.0936410728004648 0.453965235622009 no 1846 0.462697140782591 2557 16061185
SGTC_1999 st074831 12.5 µM -0.0941108498609687 0.453768877273717 no 1847 0.462510550846773 2603 17112523
SGTC_3174 9107204 49.47 µM -0.0950926909093996 0.45335852194897 no 1848 0.462120601788952 2655 3938802
SGTC_2732 terfenadine 20 µM -0.0951560887601687 0.453332026856056 no 1849 0.462095423876928 2564 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2956 9076196 2.52 µM -0.0956394362985131 0.453130034134102 no 1850 0.461903471553331 2609 16423868
SGTC_4 0960-0234 25.671 µM -0.0968299976568414 0.452632545972907 no 1851 0.461430700588799 2620 6821112
SGTC_641 4092-0595 30 µM -0.0978407827013373 0.452210237495126 no 1852 0.461029361404774 2623 786260
SGTC_2435 5706476 10.6 µM -0.100369441625218 0.451153995407777 no 1853 0.460025514640944 2620 5725375
SGTC_2694 st077685 81.9 µM -0.100736240410442 0.451000809010645 no 1854 0.459879921001033 2587 2838096
SGTC_2138 5575593 77.673 µM -0.1013867275288 0.45072916364498 no 1855 0.45962173603965 2585 762213
SGTC_2949 9072542 2.23 µM -0.101922435322573 0.450505467791042 no 1856 0.459409120941615 2659 16457352
SGTC_2844 9010103 25.97 µM -0.101929026384043 0.450502715654954 no 1857 0.459406505111612 2753 2480525
SGTC_2959 9079155 11 µM -0.103532187604431 0.44983337736092 no 1858 0.458770302366764 2727 16189457
SGTC_1677 st019204 53.9 µM -0.103716813994649 0.449756302841217 no 1859 0.458697041490552 2716 3945625
SGTC_2450 5739737 12.93 µM -0.104204321328025 0.449552796125693 no 1860 0.458503602360359 2653 2262825
SGTC_2558 carylophyllene oxide 100 µM -0.104383242815138 0.449478109858476 no 1861 0.458432610164102 2572 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1876 myriocin 605 nM -0.105103732304577 0.449177377813749 no 1862 0.458146748879647 2640 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1026 k007-1105 30.6 µM -0.105368038393271 0.449067063860554 no 1863 0.458041888261035 2592 7066794
SGTC_187 1488-2104 32.728 µM -0.105896674887169 0.448846437625537 no 1864 0.45783216614521 2666 2852859
SGTC_958 1222-0007 33 µM -0.106622646949409 0.448543479257093 no 1865 0.457544175666477 2722 7312461
SGTC_985 1493-0307 8.71 µM -0.106682543453354 0.448518484939724 no 1866 0.457520415934424 2627 3278274
SGTC_1670 st016595 4.04 µM -0.107035610702547 0.448371157042573 no 1867 0.457380364383335 2583 597879
SGTC_1203 3992-3522 103 µM -0.108560406697848 0.447734972220894 no 1868 0.456775582982245 2814 5322312
SGTC_1625 st003711 30.1 µM -0.109471687529119 0.44735482606227 no 1869 0.456414188431402 2703 24207034 YER133W GLC7
SGTC_254 nsc-64875 3.808 µM -0.109665751743589 0.447273877267531 no 1870 0.456337231347096 2755 56993
SGTC_578 3460-0051 92 µM -0.110163431858495 0.447066293113527 no 1871 0.456139881430608 2591 2876744
SGTC_1914 st062367 72.6 µM -0.110491818561612 0.446929329783768 no 1872 0.456009668992399 2638 978205
SGTC_146 3448-8650 53.125 µM -0.111927752688615 0.446330505800834 no 1873 0.45544034569971 2637 2891488 YIL048W NEO1
SGTC_328 k915-0120 63.5 µM -0.112042011582261 0.446282861941279 no 1874 0.455395047919477 2738 6624543
SGTC_1290 0986-0249 10.2 µM -0.112263662225974 0.446190439906857 no 1875 0.455307176482683 2632 53329
SGTC_472 calcifediol 10 µM -0.112459358271522 0.446108842633755 no 1876 0.455229596334023 2681 5283731 A vitamin D metabolite.
SGTC_1574 spiramycin 23.7 µM -0.112918843109386 0.445917265164023 no 1877 0.455047448617775 2584 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_933 2914-0560 114 µM -0.113275007215074 0.445768774893172 no 1878 0.45490626552194 2686 463887
SGTC_2365 9042475 200 µM -0.113891025732551 0.445511965305234 no 1879 0.454662089852177 2663 6464479
SGTC_356 1634-0012 32.5 µM -0.116012822155777 0.44462759340701 no 1880 0.45382118990201 2616 735457
SGTC_762 1165-0429 115 µM -0.116062146936666 0.444607037932745 no 1881 0.453801644193916 2647 5967793
SGTC_3234 9132280 49.47 µM -0.117930341008173 0.443828602013286 no 1882 0.453061426170625 2682 17612295
SGTC_294 k038-0071 157 µM -0.11809696556867 0.443759183656073 no 1883 0.452995413876765 2659 24152826
SGTC_582 0987-0078 156 µM -0.118236464980921 0.443701067380299 no 1884 0.452940148856265 2623 1625765
SGTC_1288 0973-0013 65.5 µM -0.118545981309834 0.443572125382217 no 1885 0.452817532052999 2700 4315430
SGTC_1984 st072354 53.1 µM -0.120172299332054 0.442894712930811 no 1886 0.452173330329325 2630 5762938
SGTC_872 0588-0139 234 µM -0.120670855143064 0.442687082134381 no 1887 0.451975872247184 2643 2047100
SGTC_1702 st027038 51 µM -0.121191682743345 0.442470192739432 no 1888 0.451769605884731 2686 5521182
SGTC_3176 9106582 49.47 µM -0.121574880702724 0.442310627767425 no 1889 0.451617854093895 2612 17018027
SGTC_629 3448-6466 76.7 µM -0.121704227503022 0.442256769418285 no 1890 0.451566632533386 2645 573744
SGTC_421 streptovitacin 30 mM -0.121807400621163 0.442213810219936 no 1891 0.451525776375115 2813 91467 include heat shock
SGTC_1987 st072290 61.9 µM -0.122508985808378 0.441921702394566 no 1892 0.451247964976147 2676 54697379
SGTC_614 0462-0418 107 µM -0.124067248332478 0.44127302669297 no 1893 0.450631014904056 2632 5188303
SGTC_1988 st071872 53.4 µM -0.124352894398726 0.441154134580748 no 1894 0.450517934296413 2618 16414116
SGTC_2507 purpurin 79.67 µM -0.126254556621853 0.440362757036112 no 1895 0.449765213445132 2613 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_345 1362-0200 395 µM -0.126895837674525 0.440095941193358 no 1896 0.449511420532418 2649 1419823
SGTC_98 0074-0023 107.663 µM -0.127496029945981 0.43984624567447 no 1897 0.449273907592573 2700 3563821
SGTC_54 0159-0055 9 µM -0.127833494900972 0.439705862020657 no 1898 0.449140371208017 2678 3319099
SGTC_3161 9100388 49.47 µM -0.128723753069459 0.439335555710178 no 1899 0.448788119771374 2649 25236368
SGTC_881 0833-0569 170 µM -0.130643705535433 0.438537125183202 no 1900 0.448028583491975 2646 5418700
SGTC_2894 9048625 32.47 µM -0.13180188422721 0.438055606256881 no 1901 0.447570498079047 2727 4092861
SGTC_3128 9127691 49.47 µM -0.132222930020162 0.437880576928723 no 1902 0.447403982408674 2801 41316314
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.132559420541738 0.437740706081115 no 1903 0.447270913416547 2965 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2770 toltrazuril 17.5 µM -0.132660630985946 0.437698636905568 no 1904 0.447230889759235 2633 68591 Kills coccidiodes.
SGTC_1825 st052143 62.6 µM -0.134992865281346 0.436729415461606 no 1905 0.446308757688443 2762 674173
SGTC_3081 9117243 49.47 µM -0.135666114268849 0.43644969946243 no 1906 0.446042618445734 2832 45595589
SGTC_1276 0871-0068 94.2 µM -0.136895506392448 0.435939003734836 no 1907 0.445556695388409 2748 3414906
SGTC_147 4466-0538 29.23 µM -0.137101627634195 0.435853390355492 no 1908 0.445475232976588 2836 6742687 YHR072W ERG7
SGTC_560 2332-1943 155 µM -0.137857610001566 0.435539415458388 no 1909 0.445176476383188 2643 21177716
SGTC_1059 3448-6867 171 µM -0.13789064989744 0.435525694240922 no 1910 0.445163420059032 2630 3934407
SGTC_596 1155-0152 116 µM -0.138896705617771 0.435107924194201 no 1911 0.44476588713535 2638 280313
SGTC_885 0865-0106 16.8 µM -0.139077479888181 0.435032864369467 no 1912 0.444694461853969 2653 2793380
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.139457984364825 0.43487488162233 no 1913 0.444544127528157 2616 5355888
SGTC_642 0335-0876 158 µM -0.139923711245522 0.434681529293353 no 1914 0.444360133360271 2650 6812350
SGTC_2066 5222451 176 µM -0.141581951742767 0.43399321718945 no 1915 0.44370511186487 2652 2281147
SGTC_465 cgp-37157 41 µM -0.141668813651654 0.433957167540463 no 1916 0.443670804769482 2715 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_696 1560-0013 611 µM -0.143046137917006 0.433385620546044 no 1917 0.443126871527856 2821 1650269
SGTC_1029 k015-0030 64.7 µM -0.144275171940784 0.432875726976726 no 1918 0.442641591545993 2768 2208316
SGTC_1707 st032323 6.317 µM -0.144981149822874 0.43258288597871 no 1919 0.442362877396583 2669 3132057 YMR211W DML1
SGTC_2879 9041815 71.43 µM -0.145167570118687 0.432505564650468 no 1920 0.44228928498184 2660 4942971
SGTC_1939 st074455 53.6 µM -0.147900753173191 0.431372223763007 no 1921 0.441210546899192 2892 1644229
SGTC_2415 st077333 57.7 µM -0.14977852959971 0.430593912252607 no 1922 0.440469674575547 2722 2766255
SGTC_2710 st078562 53.7235 µM -0.149831401981905 0.430572001292621 no 1923 0.440448816903809 2640 17250908
SGTC_224 benfluorex 43.875 µM -0.151913083746264 0.429709497525342 no 1924 0.439627744364745 2677 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3310 9130229 44.1445 µM -0.152094794142261 0.429634225264113 no 1925 0.439556085056706 2832 7761258
SGTC_2666 tannic acid 100 µM -0.154496876374034 0.428639420925566 no 1926 0.438608986971734 2739 16134267 A thiamine antagonist.
SGTC_723 4182-0001 115 µM -0.155046223863246 0.42841197623238 no 1927 0.438392438257785 2706 744821 YLR208W SEC13
SGTC_1947 st076332 61.6 µM -0.156317538235995 0.427885709060918 no 1928 0.43789136637947 2764 24208416
SGTC_1318 1280-3875 124 µM -0.156474026475337 0.42782093879003 no 1929 0.437829695459617 2748 373245
SGTC_2278 7948257 134.34 µM -0.15715307360443 0.427539904653387 no 1930 0.437562105250982 2739 1247028
SGTC_3039 9090270 49.47 µM -0.158222675458772 0.427097308025876 no 1931 0.437140668189111 2711 17173750
SGTC_3069 9117009 49.47 µM -0.158314021541147 0.427059513656398 no 1932 0.43710467994159 2702 41904981
SGTC_807 1315-0151 48 µM -0.1585445540123 0.426964134006285 no 1933 0.437013857785084 2733 4011080
SGTC_272 doxorubicin 8.13 µM -0.159121419221211 0.426725482655382 no 1934 0.436786606559321 2650 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_501 nsc-95397 161 µM -0.16228435241756 0.425417444017653 no 1935 0.43554096815167 2864 262093
SGTC_1101 ebselen 5.29 µM -0.162326020265678 0.425400217622933 no 1936 0.43552456260018 2736 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3012 9080433 71.4286 µM -0.162879482035199 0.425171418010165 no 1937 0.435306663021943 2717 17688859
SGTC_57 miconazole 162.5 nM -0.163452458613714 0.424934577577711 no 1938 0.435081101098293 2655 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2747 doxorubicin 7.63 µM -0.163551308391543 0.424893720662639 no 1939 0.435042189345416 2670 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_814 3342-0569 96 µM -0.163607338133085 0.424870562623931 no 1940 0.435020133778941 2691 4346283
SGTC_364 0083-0097 67.7 µM -0.163833830783509 0.424776952028594 no 1941 0.434930979196384 2826 5207356
SGTC_246 cycloheximide 667 µM -0.164171276999862 0.424637491614654 no 1942 0.434798155961661 2688 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1404 3909-7820 48.3 µM -0.164750311626218 0.424398209073704 no 1943 0.434570257529602 2738 23741373
SGTC_3057 9095946 49.47 µM -0.164828393358447 0.424365944402248 no 1944 0.434539527515705 2679 24540043
SGTC_385 1494-0393 12.4 µM -0.1648826216262 0.424343536677586 no 1945 0.434518185555123 2738 3090647
SGTC_430 0958-0115 16.4 µM -0.165108461492772 0.42425021975818 no 1946 0.43442930655518 2726 6833180
SGTC_3285 9112818 20.8695 µM -0.165965410620956 0.423896167479028 no 1947 0.43409208546981 2673 17017947 YPR165W RHO1
SGTC_1609 st001574 46.4 µM -0.166028534961405 0.423870089807131 no 1948 0.434067247080599 2705 3960012
SGTC_1329 1447-1697 50.6 µM -0.166294741934698 0.423760119129116 no 1949 0.433962501882084 2825 2840515
SGTC_2250 alverine citrate 130 µM -0.166784334855098 0.423557882739112 no 1950 0.433769872504507 2651 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.167019753609295 0.423460645363091 no 1951 0.433677253052959 2891 94937 An inhibitor of serotonin biosynthesis.
SGTC_2968 9090663 33.37 µM -0.167309191639907 0.423341102250773 no 1952 0.433563386098529 2804 25236811
SGTC_620 0109-0052 432 µM -0.167878411871738 0.423106024652043 no 1953 0.433339466954532 2771 493037
SGTC_3111 9122088 49.47 µM -0.167971558021545 0.423067559590974 no 1954 0.433302827273691 2770 16876704
SGTC_2495 cafestol 54.53 µM -0.168442951645888 0.422872907033666 no 1955 0.433117410136406 2914 16667697 An anti-infammatory.
SGTC_2225 6654152 15.4 µM -0.168849116912244 0.422705204319593 no 1956 0.432957661612299 2693 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2640 pentamidine 10.38 µM -0.169691658218683 0.422357369781628 no 1957 0.432626317352254 2803 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2084 5306078 60.6385 µM -0.170162237549899 0.422163122263365 no 1958 0.43244127431547 2780 679340
SGTC_1523 st012844 44.7 µM -0.171208000896992 0.421731515959864 no 1959 0.432030108288697 2842 4274103
SGTC_1685 st024049 53.0905 µM -0.171633247182898 0.421556035633559 no 1960 0.43186293391164 2785 1941139
SGTC_1787 fluconazole 80 µM -0.171750789519371 0.421507533858681 no 1961 0.431816727389003 2742 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3138 9097216 49.47 µM -0.172512290088106 0.421193342941356 no 1962 0.431517400057418 2654 25237486
SGTC_2814 7977482 42.97 µM -0.173757747319308 0.420679582416894 no 1963 0.431027925965852 2863 6456762
SGTC_414 piperonyl butoxide 100 µM -0.174819615294328 0.420241660488865 no 1964 0.430610687455403 2717 5794 A potent inhibitor of cytochrome P450.
SGTC_1778 st046819 58.9 µM -0.176079410977228 0.419722239831521 no 1965 0.430115777930821 2733 671715
SGTC_2714 st079313 56.9 µM -0.177101876361524 0.419300774506521 no 1966 0.429714184050413 2721 2939799
SGTC_183 3914-0051 30.55 µM -0.17769472519897 0.419056441631115 no 1967 0.429481364002412 2836 1596232
SGTC_3222 9128301 49.47 µM -0.180409285819573 0.417938080287663 no 1968 0.4284156324516 2763 4911358
SGTC_685 1278-0033 54.9 µM -0.180542017608993 0.417883413566039 no 1969 0.428363535511963 2835 3590572
SGTC_2629 bisabolol 100 µM -0.181355582126787 0.417548374773168 no 1970 0.428044240512567 2883 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2630 antimycin a 100 µM -0.182089900801123 0.41724602205617 no 1971 0.427756087116579 2681 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1772 st048439 82.2 µM -0.182215751361193 0.417194208508225 no 1972 0.427706706063387 2794 2927068 YDL195W SEC31
SGTC_2900 5328528 85.29 µM -0.182955431864389 0.416889706010024 no 1973 0.427416494253253 2721 795359
SGTC_3118 9124250 49.47 µM -0.183859712202902 0.416517510837545 no 1974 0.427061755473682 2796 1504786
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.184617970089978 0.416205475106367 no 1975 0.426764345069696 2809 279621
SGTC_2087 5276107 200 µM -0.185390093604069 0.415887787703849 no 1976 0.426461538951586 2718 144405
SGTC_203 k066-0004 30.888 µM -0.187295568292774 0.415104022677257 no 1977 0.425714448747943 2709 6795412
SGTC_145 3737-0113 38.366 µM -0.187457046414858 0.415037618537496 no 1978 0.425651149326323 2857 6849351
SGTC_899 1083-0020 478 µM -0.188489429459351 0.414613132350842 no 1979 0.425246500538959 2913 767123
SGTC_105 0111-0055 734.78 µM -0.192202950368725 0.413087067124521 no 1980 0.423791617465133 2827 5179370
SGTC_3294 9122953 26.2835 µM -0.192514577962653 0.412959063651895 no 1981 0.423669574960644 2744 16459826
SGTC_3284 9108171 64.8615 µM -0.193275686504273 0.41264647128932 no 1982 0.423371533336384 2854 8687505
SGTC_1975 st070967 30.8 µM -0.193512741143318 0.412549122669082 no 1983 0.423278714326877 2833 261391
SGTC_1651 st011928 86.1 µM -0.195294987196783 0.411817399941779 no 1984 0.422581010578168 2869 720198
SGTC_2309 7664088 163.95 µM -0.196148334743934 0.411467156121459 no 1985 0.422247032666248 2865 704922
SGTC_1498 4478-3555 97.6 µM -0.196453255178595 0.411342023151611 no 1986 0.422127708325905 2773 3437919
SGTC_1001 4048-4355 44.4 µM -0.197161444689418 0.411051431803921 no 1987 0.421850600523526 2760 21824233
SGTC_1166 k206-0078 225 µM -0.198809755545132 0.410375269779458 no 1988 0.421205782251808 2746 5404595
SGTC_1295 1013-0063 9.78 µM -0.199479043917497 0.410100793485292 no 1989 0.420944017234708 2842 6826038
SGTC_650 1328-0195 38 µM -0.201764848823973 0.409163713838881 no 1990 0.420050281463875 2777 2780821
SGTC_2594 a-mangostin 100 µM -0.202366407119888 0.40891718737555 no 1991 0.419815144153821 2918 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2340 7987427 183.45 µM -0.202378028492509 0.408912425139358 no 1992 0.419810601869319 2890 2239331
SGTC_3045 9092950 49.47 µM -0.202560075162214 0.408837827338779 no 1993 0.419739449210848 2819 44120432
SGTC_2218 6965428 192.983 µM -0.203438170674765 0.408478053976253 no 1994 0.419396283831677 2755 675684
SGTC_102 gallobenzophenone 83.616 µM -0.203719034324661 0.40836299476416 no 1995 0.419286533435712 2933 70837
SGTC_177 1327-0068 8.361 µM -0.203793561351776 0.408332465186339 no 1996 0.419257412277631 2757 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1117 retinoic acid 1.10837 µM -0.203843620670577 0.408311958980086 no 1997 0.419237852033691 2931 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2620 irigenin 100 µM -0.204233897971538 0.40815209512592 no 1998 0.419085361416486 2940 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3329 9141233 27.5565 µM -0.206849524363205 0.407081088321 no 1999 0.418063688801357 2918 4909101 YNL103W MET4
SGTC_2005 4024620 188 µM -0.208699012474805 0.406324206737839 no 2000 0.417341605548821 2764 236743
SGTC_916 4466-0038 42 nM -0.209854117396476 0.405851670752809 no 2001 0.416890766890496 2919 5722064 YGL116W CDC20
SGTC_154 3389-1638 511.116 µM -0.210278896909242 0.405677934319938 no 2002 0.416725002452604 2884 5238686
SGTC_2050 5263056 171 µM -0.211034835072818 0.405368798712784 no 2003 0.416430044484534 2919 763468 YGL055W OLE1
SGTC_1245 0418-0076 17.2 µM -0.212116448196059 0.404926583304877 no 2004 0.416008093932223 2963 6790114
SGTC_3066 9117245 49.47 µM -0.212189039467341 0.404896908846066 no 2005 0.415979778647429 2828 17176980
SGTC_223 busulfan 5 mM -0.212297597288854 0.404852532704591 no 2006 0.415937434898661 2878 2478 A DNA alkylator.
SGTC_3130 9127414 49.47 µM -0.214241740782219 0.404058015661092 no 2007 0.415179273616459 2751 1494646
SGTC_564 3555-0129 330 µM -0.216540437505468 0.403119113256215 no 2008 0.414283254099149 2786 563260
SGTC_1893 st059353 36.1 µM -0.217912918684666 0.402558789295383 no 2009 0.413748480682087 2835 3112488
SGTC_2526 patulin 37.61 µM -0.222417376308587 0.400721228458828 no 2010 0.4119944931146 2943 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2705 st078069 42.8 µM -0.222525282117214 0.400677235823429 no 2011 0.411952497154548 2882 1530061
SGTC_2896 9052656 71.43 µM -0.222550878229902 0.400666800606614 no 2012 0.411942535528063 2883 6469436
SGTC_1033 k072-0102 21.3 µM -0.223077083149274 0.400452289124359 no 2013 0.411737756980743 2977 5965931
SGTC_1063 disulfiram 1.84 µM -0.223218825631984 0.400394511841318 no 2014 0.411682600410625 2788 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_422 cantharidin 155 µM -0.223525626941594 0.400269460498326 no 2015 0.411563220107079 2766 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3229 9132204 49.47 µM -0.224711060562027 0.399786377297707 no 2016 0.41110202978395 2790 17682924
SGTC_2190 6049624 200 µM -0.224923998824321 0.399699617768454 no 2017 0.4110191996212 2808 2265554
SGTC_276 colchicine 750 µM -0.225005866776905 0.3996662628215 no 2018 0.410987355127941 2912 2833 A microtubule depolymerizer.
SGTC_1744 st037937 38.9 µM -0.22551568603566 0.399458566841468 no 2019 0.410789061973019 2987 1016152
SGTC_3218 9131285 49.47 µM -0.227535715698748 0.398635904372482 no 2020 0.410003600166077 2955 17156417
SGTC_256 clotrimazole 625 nM -0.227951147265366 0.398466774451373 no 2021 0.409842109745735 2844 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1213 1315-0166 115 µM -0.229248349198143 0.397938782280402 no 2022 0.409337947898346 2926 768401
SGTC_2851 9015922 71.43 µM -0.229574062084246 0.397806238667934 no 2023 0.409211382015222 3013 2996893
SGTC_3022 9087993 49.47 µM -0.230522929646706 0.397420179580292 no 2024 0.408842723969112 2839 17173644
SGTC_2739 tacrine 100.86 µM -0.230901105981647 0.397266341606299 no 2025 0.408695815751034 2917 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_391 gliotoxin 8.33 µM -0.230905384989785 0.397264601044235 no 2026 0.408694153580079 2963 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_314 1671-0008 2.74 µM -0.231127387366676 0.397174300467597 no 2027 0.40860791951656 2805 3913060
SGTC_2869 9037858 32.47 µM -0.231783703675126 0.396907372779117 no 2028 0.408353007496748 2766 27187042
SGTC_1985 st071382 65.5 µM -0.231878000182353 0.396869025801868 no 2029 0.408316386093983 2831 6123237
SGTC_3067 9117431 49.47 µM -0.232007773179536 0.396816253450545 no 2030 0.408265988196208 2851 17150885
SGTC_3134 9127454 49.47 µM -0.232416707794011 0.396649972042466 no 2031 0.408107186620027 2846 24262820
SGTC_92 0063-0024 660.874 µM -0.23258784751245 0.396580388612798 no 2032 0.408040732412565 2757 3594437
SGTC_2652 actinonin 100 µM -0.232861399271155 0.396469172472691 no 2033 0.407934516711906 2799 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_370 0180-0345 38.7 µM -0.234165249261299 0.395939190658023 no 2034 0.407428346064052 2742 3989527
SGTC_1421 4029-0249 71.4 µM -0.234228580429291 0.39591345304057 no 2035 0.407403764051892 2978 2894095
SGTC_3293 9120939 62.045 µM -0.234552024525011 0.395782013303474 no 2036 0.407278224816291 2974 934087
SGTC_2680 butyl paraben 22.24 µM -0.234600168670054 0.395762449718187 no 2037 0.407259539312466 2797 7184 An antifungal and steroid mimetic.
SGTC_178 4092-0806 87.505 µM -0.234945975173074 0.395621937443342 no 2038 0.407125332546106 2884 2169044
SGTC_1481 3346-2004 36 µM -0.236077045260113 0.395162442225856 no 2039 0.406686442892036 2839 2770522
SGTC_2022 5136654 200 µM -0.236664848022246 0.394923705905746 no 2040 0.406458403749029 2977 1713771
SGTC_979 1426-2828 121 µM -0.23680439665466 0.394867033965156 no 2041 0.40640427026162 2959 747872
SGTC_218 alverine citrate 93.75 µM -0.237961171758313 0.394397343056403 no 2042 0.405955604838225 2950 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3122 9126309 49.47 µM -0.23935943166329 0.393829805884594 no 2043 0.405413442302616 2848 17591206
SGTC_2416 tofa 880 nM -0.239575697621532 0.393742046187268 no 2044 0.405329603323315 2853 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1337 1486-1011 40.3 µM -0.239776680678398 0.39366049305658 no 2045 0.405251692900781 2827 X1337
SGTC_2282 7944268 200 µM -0.240146041564845 0.393510629221366 no 2046 0.405108521157418 3032 2970414
SGTC_2552 juarezic acid 87.02 µM -0.240369452721996 0.393419990426829 no 2047 0.405021928640667 2794 1549512
SGTC_511 blebbistatin 171 µM -0.240831954668825 0.393232369908414 no 2048 0.404842681079183 2971 3476986 A myosin inhibitor.
SGTC_1700 st030840 7.9285 µM -0.241423629056915 0.39299238489845 no 2049 0.404613400472411 2933 5499307
SGTC_2612 dictamnine 15.46 µM -0.241916590902274 0.392792469059034 no 2050 0.404422397113369 2932 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1258 0671-0043 57.1 µM -0.242475681049832 0.392565769759986 no 2051 0.404205799201007 2898 4298767
SGTC_2107 5363541 170.161 µM -0.243819038437438 0.392021215715427 no 2052 0.403685487347919 2879 244052
SGTC_785 1270-0111 65.3 µM -0.244051430010007 0.391927033040158 no 2053 0.403595494245543 2808 6741994
SGTC_176 1486-1328 72.834 µM -0.244903216740347 0.391581878691637 no 2054 0.403265685464034 2907 22310231
SGTC_2030 5175110 200 µM -0.245436110988794 0.391365986832056 no 2055 0.403059385680675 2973 2831986
SGTC_1378 2093-0007 380 nM -0.248285197281395 0.390212303525203 no 2056 0.401956875677253 2957 3618014
SGTC_2627 acetyl isogambogic acid 100 µM -0.248538865162661 0.39010963223644 no 2057 0.401858751572453 2940 6857789 A caspase activator and apoptosis inducer.
SGTC_1920 st075728 45.7 µM -0.249507396984095 0.38971769254597 no 2058 0.401484159918846 3052 3400306
SGTC_2589 lobaric acid 100 µM -0.249664653816423 0.389654065357536 no 2059 0.401423347427523 2871 73157 A novel microtubule depolymerizer.
SGTC_1752 st044819 83.042 µM -0.249928727998472 0.389547225793498 no 2060 0.401321233173186 2872 441209 YML126C ERG13
SGTC_1729 st035615 45.989 µM -0.250059896276762 0.389494160619435 no 2061 0.40127051450995 2956 17385451
SGTC_1485 3909-9022 254 µM -0.251160346260067 0.389049046036811 no 2062 0.400845070584635 2858 714516
SGTC_2215 7188065 200 µM -0.251771925945068 0.388801734640242 no 2063 0.400608679138564 2979 940217
SGTC_1129 3453-1384 223 µM -0.253053635604334 0.388283581474835 no 2064 0.400113383202898 3060 1084452
SGTC_1148 3909-7663 27.7 µM -0.254803827010735 0.387576357695078 no 2065 0.399437309645309 2987 4084526
SGTC_891 0929-0073 133 µM -0.259603373802659 0.385638858858944 no 2066 0.397584866810058 2999 5603632
SGTC_987 1497-1013 404 µM -0.2598106861649 0.385555234104174 no 2067 0.397504903792551 2848 1676435
SGTC_84 0443-0269 128.823 µM -0.261156688067718 0.385012419294857 no 2068 0.396985838622029 2864 6150058
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.262922114345818 0.38430080091106 no 2069 0.396305305509857 2885 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_182 3448-4371 550.524 µM -0.26362572200594 0.384017295103215 no 2070 0.396034168091967 2865 3491403
SGTC_1785 bathophenanthroline 24 µM -0.263729940137046 0.383975307590627 no 2071 0.395994011581365 2890 72812 An iron chelator.
SGTC_207 4185-0010 4.486 µM -0.264680042602095 0.383592592145877 no 2072 0.395627976518203 2944 3761753
SGTC_1619 st003326 88.7 µM -0.264834877813591 0.383530232962603 no 2073 0.395568333648297 3040 2849032
SGTC_3163 9099914 49.47 µM -0.26542077089654 0.383294294483438 no 2074 0.395342668469163 2964 16268368
SGTC_1256 0570-0116 285 µM -0.267089394286737 0.382622579158654 no 2075 0.394700166602079 2899 410638
SGTC_1390 3413-2614 145 µM -0.268196670629876 0.38217703246742 no 2076 0.394273968802411 2942 3421432
SGTC_1174 0739-0097 51.1 µM -0.268240319646024 0.382159472134941 no 2077 0.394257170604245 2929 728447
SGTC_2376 9072922 81.32 µM -0.268774042708254 0.381944770884582 no 2078 0.394051784735383 3008 17087968
SGTC_360 0957-0399 1.01 µM -0.269766571739216 0.38154560192457 no 2079 0.393669920766792 3025 6752301 YPR165W RHO1
SGTC_58 0957-0393 9 µM -0.271641620350427 0.380791850925538 no 2080 0.392948796957583 2972 6997992
SGTC_1351 1496-0003 46.5 µM -0.274749325157317 0.379543581357331 no 2081 0.391754416433876 3020 3891978
SGTC_1108 betulinic acid 729.144 nM -0.275214848726353 0.379356702553696 no 2082 0.391575589835624 2929 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1362 1611-0397 101 µM -0.275835409152074 0.379107629914593 no 2083 0.391337242885487 2909 27816
SGTC_831 k061-1017 217 µM -0.276901051402324 0.378680033129312 no 2084 0.390928042624449 2956 1240153
SGTC_442 cape 100 µM -0.2802273858021 0.377346274205242 no 2085 0.389651528597237 3032 5281787
SGTC_2122 5258151 111.688 µM -0.28083498896391 0.377102801232467 no 2086 0.38941848290146 2929 2173356
SGTC_2113 5491891 107.031 µM -0.280904263038253 0.377075045483421 no 2087 0.389391915410558 2911 789979
SGTC_482 fipronil 114 µM -0.28130266207293 0.376915432968733 no 2088 0.38923913434003 2917 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3238 9133470 49.47 µM -0.282934127255285 0.37626203094085 no 2089 0.388613666605343 3032 3534688
SGTC_1806 st050005 60.3 µM -0.28339405647915 0.376077893194041 no 2090 0.388437391984668 2912 5194765
SGTC_3031 9088762 49.47 µM -0.283606239875061 0.375992952733166 no 2091 0.388356077328431 2854 205253
SGTC_11 0438-0307 1.3 µM -0.28616870703009 0.37496763097014 no 2092 0.387374455054143 3000 4011476
SGTC_3262 9137218 49.47 µM -0.286504515339855 0.374833329046292 no 2093 0.387245867808864 2826 17650664
SGTC_2126 5251174 33.877 µM -0.286679483832633 0.374763358812804 no 2094 0.387178874021113 3076 790722
SGTC_135 0933-0004 26.348 µM -0.289671155081795 0.373567623434856 no 2095 0.386033912769634 3034 21230617 YGL099W LSG1
SGTC_1550 gossypolone 36.6 µM -0.290127824798377 0.373385204692851 no 2096 0.38585922485962 2914 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1565 sinapyl alcohol 95.1 µM -0.29126048779569 0.372932879968096 no 2097 0.385426052093846 3011 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2985 9022375 71.43 µM -0.291855404030904 0.372695372501763 no 2098 0.385198591035901 3113 4939335
SGTC_874 0599-0792 117 µM -0.292570705571113 0.372409867878609 no 2099 0.384925153994074 3087 765305
SGTC_1350 1495-0454 146 µM -0.292771376603738 0.372329784862199 no 2100 0.384848454109015 3087 1069057
SGTC_3307 9126885 69.2785 µM -0.295016147556402 0.371434327406592 no 2101 0.383990772219406 2922 24824909
SGTC_1345 1488-0192 31.4 µM -0.295354652855651 0.371299355098422 no 2102 0.383861485315057 3084 658348
SGTC_601 0986-0029 62.9 µM -0.297354976550429 0.370502089089789 no 2103 0.383097756692145 2946 24747981
SGTC_3052 9092717 49.47 µM -0.299431471698643 0.369675051532364 no 2104 0.382305426058377 3109 25237534
SGTC_1759 st043059 70 µM -0.300047788476052 0.369429697386428 no 2105 0.382070351999217 2923 669426
SGTC_2610 ononetin 44.17 µM -0.300278702344247 0.369337784847594 no 2106 0.381982288577708 2991 259632
SGTC_3199 9111318 49.47 µM -0.302123326553985 0.368603822477319 no 2107 0.381279025412514 3057 8548020
SGTC_373 0844-0104 25.9 µM -0.30245172113906 0.368473206854657 no 2108 0.381153865968347 3076 5375804
SGTC_1123 mangostin 811.285 nM -0.302641583179472 0.368397698081386 no 2109 0.381081510434857 3003 5281650 An antioxidant.
SGTC_1144 3486-0183 12.5 µM -0.303224791791431 0.368165785845395 no 2110 0.38085927837664 2944 6744069
SGTC_800 3448-7362 155 µM -0.303679523954509 0.367984995443817 no 2111 0.380686029622668 3015 15991913
SGTC_2979 9012552 45.46 µM -0.304159701538882 0.367794120302365 no 2112 0.38050311236705 3061 17100905
SGTC_415 dibenzyl ketone 100 µM -0.306393863571621 0.36690644970599 no 2113 0.379652390003083 3021 7593
SGTC_151 3013-0144 2.285 µM -0.308008964537435 0.366265185176262 no 2114 0.379037755513527 3141 906558 YHR107C CDC12
SGTC_2085 5307070 144.047 µM -0.309712303324133 0.365589290862783 no 2115 0.378389872912976 2921 2840351
SGTC_2038 4100038 30.985 µM -0.310802091956163 0.365157075327139 no 2116 0.377975539622842 3052 3596803
SGTC_3073 9114972 49.47 µM -0.311027774846334 0.365067589766575 no 2117 0.377889753411202 3070 41905075
SGTC_1419 3993-2473 62.6 µM -0.320009896231023 0.36151209972868 no 2118 0.374480414308968 3005 704026
SGTC_1296 1068-0102 11.9 µM -0.321306624526343 0.360999779755129 no 2119 0.373989018358473 3060 767053
SGTC_1405 3909-7894 12 µM -0.32373643044943 0.360040467751603 no 2120 0.373068793690414 3060 7104060
SGTC_526 4469-0568 170 µM -0.326811041929301 0.358827842887797 no 2121 0.371905403689062 2969 2901964
SGTC_3339 9145883 14.936 µM -0.327270042597215 0.358646934957293 no 2122 0.371731824248369 3122 2030670
SGTC_77 0828-0286 12.516 µM -0.328258674073697 0.358257389084532 no 2123 0.371358043895549 3031 745345
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.329105854612429 0.357923695790393 no 2124 0.371037839589837 2902 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1739 st037196 92.5 µM -0.330345596264239 0.357435573500807 no 2125 0.37056942200457 3180 612214
SGTC_3261 9137475 49.47 µM -0.330766260175534 0.357269998839763 no 2126 0.370410524073396 3031 17027690
SGTC_682 0kpi-0099 17 µM -0.332530401533478 0.356575920107301 no 2127 0.369744393696858 3071 1714895 YML126C ERG13
SGTC_2688 kanamycin b 96.69 µM -0.332659349057769 0.356525205951321 no 2128 0.369695719097328 3145 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2927 9011802 47.9 µM -0.33280756936055 0.356466915080622 no 2129 0.369639772065224 3091 43912568
SGTC_2700 st077718 96.8 µM -0.332985849457739 0.356396806981218 no 2130 0.369572482360487 3052 904970
SGTC_1197 1601-0112 267 µM -0.33332296683264 0.356264249877277 no 2131 0.369445252332014 2984 7350313
SGTC_617 3770-0098 35 µM -0.334151369801512 0.355938589358847 no 2132 0.369132669059412 3013 5962639
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.334293778513323 0.355882616440886 no 2133 0.369078942349075 3090 7104
SGTC_1786 berberine 21.6 µM -0.335147523062666 0.355547122272268 no 2134 0.368756902752314 2980 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2479 5617353 43.85 µM -0.335787883591657 0.355295554583792 no 2135 0.368515413853127 3162 2731746
SGTC_2915 7971052 15.16 µM -0.336968101594592 0.354832067396355 no 2136 0.368070473254502 3062 5741558
SGTC_1588 farnesol 29.9 µM -0.337062052286541 0.354795180940051 no 2137 0.368035061565043 2987 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_93 0109-0045 59.227 µM -0.339416406446608 0.353871271338123 no 2138 0.367148030414263 3016 88733
SGTC_2919 7978188 46.38 µM -0.340235433270354 0.353550065296491 no 2139 0.366839618137348 3184 2980291
SGTC_1464 k208-0027 110 µM -0.34083275511202 0.353315873270797 no 2140 0.366614745140272 3198 X1464
SGTC_1832 st054113 55 µM -0.341172462120777 0.353182709080112 no 2141 0.366486876488356 3131 1251267
SGTC_1899 st063254 59.6 µM -0.342404190966252 0.352700025694584 no 2142 0.366023367485806 2965 3093813
SGTC_1926 methyl fluorone black 53.6 µM -0.342449395207129 0.352682315800285 no 2143 0.366006360497786 3029 72721 Reacts with homocysteine.
SGTC_594 1487-1584 10.8 µM -0.344323239617919 0.3519484716167 no 2144 0.365301604464808 3020 5013332
SGTC_806 3966-4455 5.86 µM -0.347104429583127 0.350860304929028 no 2145 0.364256432912886 3030 714982
SGTC_1021 4476-0760 85.3 µM -0.347410494394406 0.35074062868739 no 2146 0.364141475185596 3016 746768
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.347451566133924 0.350724570106362 no 2147 0.364126049599149 3032 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2069 5228469 200 µM -0.34774463438298 0.350609991511084 no 2148 0.364015986397876 3122 2835210
SGTC_1031 k035-0009 16 µM -0.347861658679777 0.350564243235201 no 2149 0.363972040489168 3192 5180959
SGTC_2377 9073351 62.6 µM -0.348355930767287 0.350371041500165 no 2150 0.363786447185308 2996 7337946 YHR072W ERG7
SGTC_1902 st060212 70.5 µM -0.349231007513901 0.350029085285084 no 2151 0.36345794463886 3081 688944
SGTC_1768 st044301 37.178 µM -0.349254722880777 0.350019819654995 no 2152 0.363449043320405 3065 3931349
SGTC_1703 st026983 48.3 µM -0.349453066392731 0.349942330038602 no 2153 0.363374600015339 3169 1104023
SGTC_1260 0700-1617 7.75 µM -0.350554624296148 0.349512082908176 no 2154 0.362961251620167 3134 2853078
SGTC_834 0312-0008 75.7 µM -0.351459521097794 0.349158792334682 no 2155 0.362621817675956 3017 6385573 YIL048W NEO1
SGTC_3149 9097855 49.47 µM -0.3525109946027 0.348748439318426 no 2156 0.36222753724376 3161 25236625 YMR079W SEC14
SGTC_2746 daunorubicin 9.88 µM -0.35526984006157 0.347672601184348 no 2157 0.36119372388484 3069 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1938 st074717 56.4 µM -0.355537155810358 0.347568423846475 no 2158 0.36109360721739 2966 17250979
SGTC_502 l-744,832 89.3 µM -0.355645779279856 0.347526094784946 no 2159 0.361052927634643 3133 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_114 0364-0001 490.298 µM -0.355715801122529 0.34749880925046 no 2160 0.361026705227337 3090 4003655
SGTC_2418 pentamidine 31.67 µM -0.356194881576098 0.347312146331358 no 2161 0.360847312411961 3126 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2575 plumbagin 510 nM -0.356459869062346 0.347208915821475 no 2162 0.360748100363001 2976 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2393 9031399 185.94 µM -0.356579200781997 0.347162431764147 no 2163 0.36070342529639 3169 1526623 YDL150W RPC53
SGTC_2774 tamoxifen 10.92 µM -0.35789096358631 0.34665160400139 no 2164 0.360212456725155 3046 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2936 9038235 15.59 µM -0.358424482241821 0.346443920394216 no 2165 0.360012836434061 3000 4749415
SGTC_2946 9065502 71.43 µM -0.35844489119885 0.346435976685073 no 2166 0.360005201016489 3065 16489101
SGTC_2628 lathosterol 100 µM -0.358841121615071 0.346281766651795 no 2167 0.359856974005112 3209 6710616
SGTC_2144 5628481 200 µM -0.359040911715624 0.346204019440606 no 2168 0.359782241924683 3045 2818399
SGTC_405 ebelactone b 50 µM -0.360199916630452 0.345753127041451 no 2169 0.359348818524038 3045 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2716 st080858 38.6235 µM -0.360391805955598 0.345678496640621 no 2170 0.359277076715176 3178 5296050
SGTC_1747 st037496 66.6 µM -0.361266123071751 0.345338529510717 no 2171 0.358950257940544 3045 723305
SGTC_23 0213-0011 39.996 µM -0.361351873154802 0.345305193390696 no 2172 0.358918210208268 3206 627608
SGTC_2017 5132927 60.65 µM -0.363712808997291 0.344387830425705 no 2173 0.358036238676349 3037 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1478 0453-0656 35.7 µM -0.364153536886726 0.344216682770282 no 2174 0.357871680290429 3125 5258496
SGTC_3198 9112019 49.47 µM -0.36466394137679 0.344018517498547 no 2175 0.357681139151822 3030 45595555
SGTC_3029 9088683 49.47 µM -0.36555321348244 0.343673358685102 no 2176 0.357349246170725 3183 25236615
SGTC_2399 5884133 200 µM -0.365924295981827 0.343529366593278 no 2177 0.357210783127837 3042 722445
SGTC_1383 3049-0032 20.7 µM -0.366449378056794 0.34332565644701 no 2178 0.357014889922366 3175 712864
SGTC_2172 5754775 163.918 µM -0.367280482732791 0.343003315220698 no 2179 0.356704905435416 3040 2263357
SGTC_2988 9073640 71.4286 µM -0.367565965665127 0.342892617945626 no 2180 0.35659844815342 3252 9102229
SGTC_611 3453-1652 23.7 µM -0.368066914107641 0.342698405560032 no 2181 0.356411670259543 3154 1560575
SGTC_2532 xanthone 78.9 µM -0.369947909613741 0.341969535047092 no 2182 0.355710651572313 3164 7020 An insecticide.
SGTC_290 2043-6722 48.1 µM -0.369983407377141 0.341955785601459 no 2183 0.355697426772188 3155 773758 YLR208W SEC13
SGTC_1864 st057645 30.4 µM -0.370445339776389 0.341776883179696 no 2184 0.355525348287971 3137 688666
SGTC_118 0083-0097 135.343 µM -0.37049870540434 0.341756217422318 no 2185 0.355505470487113 3089 5207356
SGTC_2853 9015042 58.44 µM -0.370548168706981 0.341737063257895 no 2186 0.355487046587904 2963 6457456
SGTC_2932 9016711 44.54 µM -0.370823511229718 0.341630447094739 no 2187 0.355384494245283 3189 7117328
SGTC_1745 st081495 74 µM -0.370912419545276 0.341596023350293 no 2188 0.355351382249764 3088 13842402 YBL026W LSM2
SGTC_156 3474-0145 5.642 µM -0.371697623112813 0.341292063490169 no 2189 0.355058997450308 3175 2265471
SGTC_3246 9135460 32.98 µM -0.372547525481979 0.340963174109278 no 2190 0.35474261704027 3138 41446951
SGTC_835 0312-0010 67.2 µM -0.372801100669791 0.340865070714912 no 2191 0.354648241798385 3025 1626196
SGTC_2765 myclobutanil 7.74 µM -0.374519278979496 0.340200624123591 no 2192 0.354009007994 3159 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1484 3473-2379 286 µM -0.375461728786245 0.339836374415036 no 2193 0.353658551995819 3137 671917
SGTC_2496 diffractaic acid 79.83 µM -0.375973420610275 0.33963867199536 no 2194 0.353468328029685 3291 94870 An apoptosis inducer which activates caspases.
SGTC_2679 rapamycin 1 nM -0.376855423004591 0.339297996221488 no 2195 0.353140525199172 3148 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_735 3076-0345 636 µM -0.377600507135704 0.339010307795939 no 2196 0.35286369394833 3218 2888990
SGTC_164 4100-3994 89.624 µM -0.377740513266579 0.338956259748819 no 2197 0.352811684251818 3193 4615967
SGTC_516 3992-2719 87.3 µM -0.378118686838576 0.33881028597799 no 2198 0.352671213492864 2988 5350887 YDR037W KRS1
SGTC_2706 st078239 82.5 µM -0.379884678068563 0.338128939829773 no 2199 0.35201551069583 3100 15434492
SGTC_780 0109-0199 192 µM -0.380035240214245 0.338070875155841 no 2200 0.351959628121189 3248 610414
SGTC_1342 1486-1464 234 µM -0.38045468547079 0.337909135343873 no 2201 0.351803963883508 3071 3253938
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.381547344520975 0.337487942091575 no 2202 0.351398573692607 3098 65057 A dermal irritant. YDR527W RBA50
SGTC_600 1495-0418 41.6 µM -0.381626463043446 0.337457451738429 no 2203 0.351369226285555 3073 5377768
SGTC_2684 capsaicin 100 µM -0.382151653977488 0.337255082995562 no 2204 0.351174439858818 3188 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3086 9117350 49.47 µM -0.382366927746263 0.33717214641624 no 2205 0.351094608935179 3134 2679265
SGTC_123 0083-0120 66.675 µM -0.382841853354246 0.336989204108996 no 2206 0.350918513415029 3090 16001701
SGTC_3331 9141060 1.957 µM -0.383114614833325 0.336884153259686 no 2207 0.350817391890115 3062 4906567 YPR165W RHO1
SGTC_2571 chrysanthemic acid 100 µM -0.383387251849982 0.33677916305973 no 2208 0.350716327066761 3104 2743 An insecticide.
SGTC_1923 st058458 19.1 µM -0.383649393922207 0.336678226367088 no 2209 0.350619162614261 3279 3534982
SGTC_3206 9114350 49.47 µM -0.384700468194643 0.336273632892691 no 2210 0.350229674139337 3176 17087243
SGTC_783 0848-0141 92.7 µM -0.386996690431511 0.335390400423606 no 2211 0.349379329043199 3074 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1637 st007924 17.4 µM -0.38702513526979 0.335379464923483 no 2212 0.349368799978958 3058 683336
SGTC_3142 9086498 49.47 µM -0.387371195605434 0.335246434635417 no 2213 0.349240712508533 3157 25236367
SGTC_1775 st081588 35.1725 µM -0.387426997678417 0.335224985495291 no 2214 0.349220060068877 3129 1426443 YGL099W LSG1
SGTC_1218 1348-1416 30.7 µM -0.387685227962988 0.335125734215514 no 2215 0.349124494427388 3075 6787668
SGTC_2154 5570129 200 µM -0.387708412729369 0.335116823671391 no 2216 0.349115914696946 3146 673366
SGTC_1804 st050076 49.1 µM -0.388506777401426 0.334810046785416 no 2217 0.34882051977865 3186 3895976
SGTC_2740 felodipine 17.08 µM -0.388730645304871 0.334724043844546 no 2218 0.348737705095802 3155 3333 L-type calcium channel blocker
SGTC_666 0272-0154 136 µM -0.390192364184051 0.334162711135804 no 2219 0.348197153767986 3114 6870312
SGTC_90 0870-0863 4.608 µM -0.391339706297763 0.333722365744519 no 2220 0.347773076483182 3051 1738164
SGTC_346 4513-0042 7.16 µM -0.391613081728383 0.333617479078096 no 2221 0.347672060309972 3046 2827372
SGTC_2101 5377231 179.231 µM -0.391790680034459 0.333549346438509 no 2222 0.347606440962949 3198 2844213
SGTC_2181 6316240 54.2555 µM -0.393300580154839 0.332970320270516 no 2223 0.347048744895072 3181 12779990
SGTC_769 0302-0231 76 µM -0.394330872232758 0.332575445632434 no 2224 0.346668386623623 3209 571869 YER009W NTF2
SGTC_2067 5224629 34.075 µM -0.394985385902012 0.332324690038545 no 2225 0.346426836645007 3240 2835000
SGTC_2522 biochanin a 4.94 µM -0.395335872413563 0.3321904433896 no 2226 0.346297514346907 3220 5280373 A possible chelator.
SGTC_884 0851-0618 334 µM -0.395401724181557 0.332165222626698 no 2227 0.346273218401034 3195 9642473
SGTC_2290 7904846 200 µM -0.396242808794047 0.331843160043713 no 2228 0.345962956720267 3158 2962154
SGTC_2926 9010726 65.15 µM -0.397180461679337 0.331484266610578 no 2229 0.345617194540383 3214 2994293
SGTC_924 2046-0044 21.3 µM -0.39730967270486 0.331434822273195 no 2230 0.345569557692876 3070 3623589
SGTC_692 k241-0027 77.8 µM -0.397379866123023 0.331407963048706 no 2231 0.345543680174328 3271 3600480
SGTC_2608 thymoquinone 42.66 µM -0.397440940862317 0.331384593754842 no 2232 0.345521164936861 3187 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3354 9151612 71.43 µM -0.398704907845961 0.330901104057123 no 2233 0.345055325584133 3219 27261949
SGTC_2887 9044784 58.44 µM -0.398988610405585 0.330792621527289 no 2234 0.344950798265516 3103 6465546
SGTC_1840 st055363 71 µM -0.399466348262682 0.330609975657661 no 2235 0.344774807357516 3142 676033
SGTC_2378 9074213 121.43 µM -0.399639084553722 0.330543946080942 no 2236 0.344711182363461 3105 657714
SGTC_2025 5147754 141 µM -0.399777177886397 0.33049116279507 no 2237 0.344660320777045 3145 315777 YLR208W SEC13
SGTC_870 0573-2213 57.6 µM -0.399812914120421 0.330477503916768 no 2238 0.344647159110434 3168 3916321
SGTC_3336 9143619 71.43 µM -0.400205261248983 0.330327558320783 no 2239 0.344502669904365 3233 45595730
SGTC_988 1497-1057 103 µM -0.40220555816927 0.32956351704356 no 2240 0.343766376015028 3234 3533044
SGTC_2184 6075246 200 µM -0.403443352754251 0.329091079980478 no 2241 0.343311049782345 3180 2267320
SGTC_1428 4049-0204 61.7 µM -0.405890463100208 0.328157879000072 no 2242 0.342411542848637 3228 X1428
SGTC_718 1130-0073 349 µM -0.406301891132359 0.328001086747833 no 2243 0.342260398017806 3281 6740020
SGTC_2444 5485484 36.41 µM -0.406584610395834 0.327893362044389 no 2244 0.342156551106356 3227 6790631
SGTC_2598 perillyl alcohol 100 µM -0.407547795947952 0.327526466360916 no 2245 0.341802848642467 3255 10819 An apoptosis inducer.
SGTC_2088 5278280 127.392 µM -0.408943408380131 0.3269951465278 no 2246 0.341290596084488 3214 791502
SGTC_2730 imipramine 71.33 µM -0.409109521842505 0.326931929242325 no 2247 0.341229644417576 3184 3696 A tricyclic antidepressant.
SGTC_3148 9097893 49.47 µM -0.409430584853211 0.326809757365293 no 2248 0.341111849176291 3090 17174100
SGTC_1872 amphotericin b 148 nM -0.409942084913633 0.326615158152985 no 2249 0.340924216216171 3219 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2368 9071271 200 µM -0.410743001202105 0.326310545855613 no 2250 0.340630496085907 3147 27209959
SGTC_3252 9135871 49.47 µM -0.411057207266424 0.326191075558622 no 2251 0.340515293632841 3260 17682838
SGTC_2407 paclitaxel 400 µM -0.411596532708068 0.325986049902088 no 2252 0.340317586712014 3289 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3071 9117417 49.47 µM -0.413321509740766 0.325330649802328 no 2253 0.3396855363 3126 45595590 YGL055W OLE1
SGTC_1309 pyrazolanthrone 13.4 µM -0.413494234905974 0.325265053071419 no 2254 0.339622272700132 3243 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1684 st024538 14.6195 µM -0.415552495965854 0.32448379373087 no 2255 0.338868746890885 3134 6732859
SGTC_660 4031-1742 102 µM -0.416434387329997 0.324149287987721 no 2256 0.338546084984111 3174 6738706
SGTC_350 k064-0020 19.8 µM -0.416702078025543 0.324047779649414 no 2257 0.338448167109713 3303 2790705
SGTC_2727 riluzole 51.77 µM -0.416996408626006 0.323936184554699 no 2258 0.33834051730121 3180 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1314 1222-0010 41.1 µM -0.417893086112594 0.323596307919755 no 2259 0.338012643877277 3182 3526027
SGTC_2236 dapsone 200 µM -0.418434510391494 0.323391157665304 no 2260 0.337814729559909 3210 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2131 toluylene red 5.2905 µM -0.419555722695971 0.322966491548824 no 2261 0.33740501989955 3128 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2749 bexarotene 57.39 µM -0.419611504126035 0.322945370005739 no 2262 0.337384641463573 3194 82146 An retinoic acid receptor inhibitor.
SGTC_1051 3253-3903 78 µM -0.420246786085459 0.322704861874748 no 2263 0.337152589775465 3082 5509239
SGTC_74 000s-0487 160.283 µM -0.421018569955404 0.322412775951304 no 2264 0.336870760897486 3227 677548
SGTC_1827 berberine 7.24 µM -0.422765622373963 0.321751999224997 no 2265 0.336233135980253 3129 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.422827467140907 0.321728618377782 no 2266 0.336210573000617 3213 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3088 9117578 49.47 µM -0.422941598265959 0.321685472160342 no 2267 0.336168935808485 3255 678341
SGTC_1267 0828-0272 9.49 µM -0.423700317637867 0.321398706464601 no 2268 0.33589219174918 3303 745334
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.424098613390965 0.321248209124417 no 2269 0.335746948355759 3182 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3023 9089636 49.47 µM -0.424714742431179 0.321015460591291 no 2270 0.335522317736232 3270 17249241
SGTC_211 3455-0679 143.504 µM -0.425560264059209 0.320696171308029 no 2271 0.33521414999712 3248 748649
SGTC_3083 9117465 49.47 µM -0.426058675688646 0.320508021207082 no 2272 0.335032545558657 3227 16420915
SGTC_722 3534-0461 190 µM -0.426276091349088 0.32042596136482 no 2273 0.334953338679503 3186 658262
SGTC_1910 st062352 60.4 µM -0.426984665822083 0.320158582928096 no 2274 0.334695248288333 3094 2245730
SGTC_87 0100-0052 35.5 µM -0.427508379220179 0.319961021254117 no 2275 0.334504541664476 3278 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_902 1120-0002 2.07 µM -0.429012145433455 0.31939403576637 no 2276 0.333957192999304 3177 3280475
SGTC_1039 k821-0043 94 µM -0.429261120802017 0.31930020187415 no 2277 0.333866603680701 3279 15992768
SGTC_2646 retinol 96.75 µM -0.429324547544279 0.319276299438833 no 2278 0.333843527501717 3249 445354 A vitamin A analog and teratogen.
SGTC_990 3985-0011 41.3 µM -0.429984905824151 0.319027487353786 no 2279 0.333603310570317 3183 5399565 YGL099W LSG1
SGTC_1070 indatraline 8.81 µM -0.430215487476472 0.318940627194145 no 2280 0.333519448501181 3185 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2539 epi(13)torulosol 80 µM -0.430797712169485 0.31872134727998 no 2281 0.33330773161646 3252 6708597
SGTC_2729 fluphenazine 10.66 µM -0.431973695077373 0.318278637235425 no 2282 0.332880265852231 3146 3372 An atypical antipsychotic.
SGTC_923 1900-2434 73.3 µM -0.432350686110518 0.318136770228294 no 2283 0.332743276831099 3133 5910570
SGTC_833 3852-0053 558 µM -0.432451677817138 0.318098770163836 no 2284 0.332706582786251 3314 3123681
SGTC_1127 asiatic acid 681.4 nM -0.432966669968965 0.317905024283845 no 2285 0.332519491903164 3137 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1500 4488-1866 171 µM -0.433964612662636 0.317529728825437 no 2286 0.332157069259227 3313 2900003
SGTC_3112 9123419 49.47 µM -0.436264846559685 0.316665396332524 no 2287 0.331322291973806 3220 17015854
SGTC_2864 9034755 47.6 µM -0.436617538759612 0.316532957538037 no 2288 0.331194370482452 3275 4930451
SGTC_1193 1488-0126 41.5 µM -0.437208543353044 0.31631108323266 no 2289 0.330980057229838 3181 1384710
SGTC_869 0564-0080 44.1 µM -0.438826587611502 0.315703977259494 no 2290 0.330393596836159 3206 6843321
SGTC_3119 9125183 49.47 µM -0.439360300082211 0.315503832051853 no 2291 0.330200243904462 3179 22695334
SGTC_268 camptothecin 39.6153 µM -0.439680672014402 0.315383716743653 no 2292 0.33008420158547 3271 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1683 st010134 710 nM -0.439753342058602 0.315356473672699 no 2293 0.330057881951582 3140 3818134
SGTC_1456 k015-0012 13 µM -0.440322866697538 0.315143000934706 no 2294 0.329851640673682 3354 2989616
SGTC_1415 3966-0071 78.1 µM -0.441106756644698 0.314849279412948 no 2295 0.329567856127362 3245 2893185
SGTC_674 0498-0004 451 µM -0.443039762890118 0.314125487613743 no 2296 0.3288684870097 3237 4231473
SGTC_88 0180-0332 8.668 µM -0.444278109657338 0.313662178186312 no 2297 0.328420762859597 3170 3101745
SGTC_349 k015-0014 24 µM -0.446720457737039 0.312749270648666 no 2298 0.327538454468216 3123 2196908
SGTC_336 4111-0029 111 µM -0.447353387760662 0.31251287930588 no 2299 0.327309962669667 3209 3131175
SGTC_1801 st050089 28.441 µM -0.448740162198564 0.311995206333313 no 2300 0.326809554438479 3261 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_981 1488-1094 54.9 µM -0.448910816131285 0.311931528065211 no 2301 0.326747996610425 3192 3449522
SGTC_1712 st032288 53.4 µM -0.449365729928496 0.311761807771666 no 2302 0.326583924371829 3289 2883011
SGTC_788 1182-0090 188 µM -0.451127746862928 0.311104807912082 no 2303 0.32594874037335 3367 5715185
SGTC_732 3970-1727 52.7 µM -0.453169039034852 0.310344427243388 no 2304 0.325213512452181 3299 1275699
SGTC_3024 9090631 49.47 µM -0.454230583074095 0.309949322318526 no 2305 0.324831436491702 3295 25236383
SGTC_2815 7968870 71.43 µM -0.454433699257046 0.309873747804239 no 2306 0.324758350935086 3203 2977326 YHR190W ERG9
SGTC_1335 1486-0900 202 µM -0.45486030304687 0.309715045231573 no 2307 0.324604871712098 3224 X1335
SGTC_2366 9070441 60.58 µM -0.455410084119624 0.309510571292796 no 2308 0.324407120925568 3198 6837235
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.456863525208522 0.308970293235294 no 2309 0.323884571176169 3248 77254
SGTC_3314 9135860 59.4275 µM -0.457266436016245 0.308820594927828 no 2310 0.323739775664913 3319 25252478
SGTC_2292 7671323 168.05 µM -0.457914026155025 0.308580054505848 no 2311 0.323507104758218 3345 937504
SGTC_2385 9074692 200 µM -0.459460609068205 0.308005925246623 no 2312 0.322951716427226 3230 17046906
SGTC_139 0099-0334 718.624 µM -0.460146831114733 0.307751333215029 no 2313 0.322705415768611 3257 97690
SGTC_141 0443-0274 32.331 µM -0.460198477259796 0.307732175963283 no 2314 0.322686881940889 3380 1627241
SGTC_860 0443-0016 25.1 µM -0.460288539434275 0.30769877019836 no 2315 0.322654563122204 3273 5337942
SGTC_2483 5729050 27.16 µM -0.460410874605648 0.30765339632169 no 2316 0.322610665281857 3378 2865180
SGTC_2173 5763948 167 µM -0.46175070510223 0.307156648484962 no 2317 0.322130052436657 3281 2867177
SGTC_3159 9100096 49.47 µM -0.463383608791992 0.3065517207258 no 2318 0.321544712769783 3191 25236875
SGTC_1644 st010134 20.9 µM -0.464404278762267 0.306173869288871 no 2319 0.321179062561459 3321 3818134
SGTC_2965 9082772 38.63 µM -0.465063716480921 0.305929855384548 no 2320 0.320942914228092 3382 16459634
SGTC_710 3448-4187 58 µM -0.465073351072736 0.305926290902914 no 2321 0.320939464563411 3297 3946412
SGTC_264 promethazine 12.5 mM -0.46604279663728 0.3055677219968 no 2322 0.320592433741069 3368 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_478 N-arachidonylglycine 10 µM -0.467668411857038 0.304966874009161 no 2323 0.320010866893218 3267 5283389
SGTC_726 3448-4391 34.2 µM -0.467818066187014 0.304911586261632 no 2324 0.319957349978593 3424 1356692
SGTC_2969 9091408 28.7 µM -0.468080602917355 0.304814606413697 no 2325 0.319863474972776 3172 4286311
SGTC_274 sirtinol 40.1 µM -0.468547665218935 0.30464210966902 no 2326 0.319696496474301 3252 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_635 k038-0028 24.7 µM -0.470548248593311 0.303903740441846 no 2327 0.318981685740931 3239 4035102
SGTC_825 1988-2224 89.6 µM -0.471378382163013 0.303597591743029 no 2328 0.318685275383346 3222 1180859
SGTC_583 1488-1091 88.9 µM -0.472731590543949 0.303098831357344 no 2329 0.318202342791395 3337 4303273
SGTC_489 paxilline 115 µM -0.475181188430294 0.302196901537718 no 2330 0.317328917056841 3297 105008 A toxic potassium channel blocker.
SGTC_2997 9067075 71.4286 µM -0.476784401549224 0.301607259371817 no 2331 0.316757827141492 3299 27209819
SGTC_2840 9008771 71.43 µM -0.476975408554728 0.301537043845828 no 2332 0.31668981648887 3280 2992978
SGTC_2156 5649887 115 µM -0.478159629110682 0.301101880245068 no 2333 0.316268296949705 3340 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1970 st070122 35.8 µM -0.479568508720604 0.300584530513539 no 2334 0.315767121584884 3393 102928
SGTC_2405 ticlatone 3.52 µM -0.47960436630944 0.300571368613025 no 2335 0.315754370515787 3034 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3325 9138760 55.175 µM -0.480256260653951 0.300332129405734 no 2336 0.315522593122171 3242 43844959
SGTC_1482 3346-2049 8.48 µM -0.482053762669256 0.299672908982085 no 2337 0.314883877383826 3332 3826804
SGTC_1045 1348-1485 165 µM -0.484399412512288 0.298813646697919 no 2338 0.314051217642725 3276 6810614
SGTC_1604 st002052 72.4 µM -0.485065348730126 0.29856990406217 no 2339 0.313814995508466 3380 6254834 YHR062C RPP1
SGTC_1381 2324-0066 62.1 µM -0.487912438166785 0.297528847948025 no 2340 0.312805931971711 3313 10885928
SGTC_1408 3909-7976 48.8 µM -0.488288249309902 0.297391554150579 no 2341 0.312672841753883 3303 24152374
SGTC_2639 lactacystin 53 µM -0.489024872157365 0.297122530235426 no 2342 0.312412044094982 3396 3870 A proteasome inhibitor.
SGTC_1149 3909-7961 23.3 µM -0.489080979348666 0.297102043745642 no 2343 0.312392183471021 3298 735261
SGTC_2984 9022109 38.96 µM -0.48940912662243 0.29698223985356 no 2344 0.312276037982639 3391 6459207
SGTC_3043 9092303 49.47 µM -0.490362598053043 0.296634260672575 no 2345 0.311938669139828 3292 25236084
SGTC_790 1575-0012 79.1 µM -0.490704783410244 0.296509422168699 no 2346 0.311817631401669 3378 378741 YLR208W SEC13
SGTC_865 0488-0499 301 µM -0.491498603627963 0.296219907758006 no 2347 0.311536919742166 3404 9634651
SGTC_1581 himbacine 57.9 µM -0.492109675454703 0.295997131933638 no 2348 0.311320906371399 3257 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_250 brefeldin a 552.239 µM -0.493537408723262 0.295476929381663 no 2349 0.310816457131833 3284 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3094 9117742 49.47 µM -0.494479870836225 0.295133768627899 no 2350 0.310483659400906 3299 17149698
SGTC_1635 st007035 42.4 µM -0.495531195160816 0.294751186640415 no 2351 0.3101126037317 3361 3716403
SGTC_2695 st077686 51.995 µM -0.49649249445632 0.294401565472597 no 2352 0.309773490738579 3302 2876092
SGTC_1065 prochlorperazine maleate 2.48 µM -0.497111064127468 0.294176695147742 no 2353 0.309555366395415 3384 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2502 avocadyne acetate 18.59 µM -0.500302941278013 0.293017606631152 no 2354 0.308430891684736 3236 3952079
SGTC_1773 st048542 73.5835 µM -0.500854200421232 0.292817638826796 no 2355 0.308236868624834 3250 3237138
SGTC_2161 5662504 8.5105 µM -0.501505752512158 0.292581371747183 no 2356 0.308007615184511 3290 2859334
SGTC_13 0199-0087 65 µM -0.501629875824068 0.292536371958264 no 2357 0.307963949966766 3370 4589825
SGTC_1557 sumaresinolic acid 42.3 µM -0.50295577166329 0.292055881169607 no 2358 0.30749768410667 3295 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_580 1123-0028 41 µM -0.503510827978634 0.2918548437095 no 2359 0.307302584709481 3381 1677248 YPR107C YTH1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.507150387742101 0.290538220926837 no 2360 0.306024651267956 3298 4330530
SGTC_646 4092-0839 27.3 µM -0.507654568373063 0.290356051324384 no 2361 0.305847807368373 3433 877796
SGTC_855 0428-0020 25 µM -0.507842520975099 0.29028815433005 no 2362 0.305781893623752 3315 6812414
SGTC_89 0302-0250 142.109 µM -0.508481474787655 0.290057390895293 no 2363 0.305557863770354 3409 4203518 YLR208W SEC13
SGTC_2288 7946289 167.31 µM -0.508603636003524 0.290013281158847 no 2364 0.305515039915018 3443 1246052
SGTC_282 k297-0036 65.7 µM -0.509354253363017 0.289742318738308 no 2365 0.305251967935725 3389 5061378
SGTC_2142 5622915 118.518 µM -0.509959366724703 0.289523967758607 no 2366 0.305039964551334 3322 5322196
SGTC_782 0083-0095 30.5 µM -0.510882197186632 0.289191119618128 no 2367 0.304716773936065 3364 3591729 An indicator and reagent.
SGTC_1754 st042065 16.137 µM -0.511481503240434 0.288975057235829 no 2368 0.304506968538543 3369 1126236 YIL048W NEO1
SGTC_64 000l-0018 272.079 µM -0.512142044485376 0.288737006306658 no 2369 0.304275800386996 3340 6811119
SGTC_1316 1272-0050 65.9 µM -0.514518817530615 0.287881211355992 no 2370 0.303444653772207 3379 7340392
SGTC_2463 5473429 200 µM -0.516282770487562 0.287246847429439 no 2371 0.302828464023221 3325 5399405
SGTC_2796 7949634 45.45 µM -0.517890623904836 0.286669197968549 no 2372 0.302267292082175 3343 2971588
SGTC_1098 clofazimine 15.1 µM -0.518306066910847 0.286520032403642 no 2373 0.302122370331097 3427 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1882 5615643 20 µM -0.519419554053125 0.286120414542171 no 2374 0.301734099132662 3355 2253075
SGTC_1761 st044296 37 µM -0.521445306794698 0.285394074751657 no 2375 0.30102829835045 3321 1826700
SGTC_3356 9151811 4.48 µM -0.523977767755299 0.28448729014762 no 2376 0.300147001586998 3288 1859254 YPR165W RHO1
SGTC_1962 st076595 64.5 µM -0.525081726137986 0.284092432933855 no 2377 0.299763189440311 3336 279619
SGTC_1623 st003709 20.3 µM -0.525246453154514 0.284033536845499 no 2378 0.29970593801926 3336 16192618
SGTC_2027 5150920 200 µM -0.526626787743453 0.283540245135861 no 2379 0.299226392917674 3345 786715
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.526892039071685 0.283445499018643 no 2380 0.299134281260155 3410 229346 A bile salt which induces apoptosis.
SGTC_2828 7998861 71.43 µM -0.527569181834315 0.283203696698878 no 2381 0.298899193822338 3382 2988188
SGTC_2805 7950783 58.44 µM -0.52758058969139 0.283199623891177 no 2382 0.298895234011833 3386 1178958 YDL195W SEC31
SGTC_1724 st037281 8.293 µM -0.528148978530896 0.282996734560317 no 2383 0.298697969287891 3344 574124 YDL195W SEC31
SGTC_2801 7907800 81.82 µM -0.528837792683518 0.28275095235113 no 2384 0.298458989178798 3377 6620925
SGTC_892 0929-0076 29 µM -0.528895863069862 0.282730236402736 no 2385 0.298438845969213 3336 5751038
SGTC_2238 6671620 73.2395 µM -0.529375555298943 0.282559139566635 no 2386 0.29827247602816 3362 729941
SGTC_398 bronopol 33.3 µM -0.52964005622392 0.282464818555322 no 2387 0.298180758183839 3297 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1513 0337-0559 19 µM -0.531189734405165 0.28191250786446 no 2388 0.297643652984288 3292 775073
SGTC_62 0180-0423 3.232 µM -0.533841231213787 0.280968713639571 no 2389 0.29672569237523 3372 30102 YGL099W LSG1
SGTC_2561 acetosyringone 100 µM -0.538051012763641 0.279473395700296 no 2390 0.295270915446056 3293 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_976 1348-1067 47.6 µM -0.538654937176868 0.279259198637451 no 2391 0.295062486428559 3398 5310671 YGL099W LSG1
SGTC_826 1683-5028 118 µM -0.538774247279731 0.279216891732248 no 2392 0.295021317625161 3421 722377
SGTC_43 0570-0105 72.5 µM -0.538797555108959 0.279208627229076 no 2393 0.295013275401131 3418 1114046 YDL195W SEC31
SGTC_3326 9140064 16.379 µM -0.540201434921413 0.278711058115331 no 2394 0.294529061606672 3342 1868434
SGTC_1583 clindamycin 39.6 µM -0.542335944311349 0.277955364250877 no 2395 0.293793549102574 3347 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_287 k060-0039 29.6 µM -0.54316430338599 0.277662364612428 no 2396 0.293508340935749 3452 5861974
SGTC_317 4495-0002 170 µM -0.546077930522032 0.276632983145473 no 2397 0.292506184733476 3409 15991618
SGTC_1800 st050079 29.0735 µM -0.546705660932716 0.276411451771846 no 2398 0.292290482210502 3404 3645560
SGTC_2600 tangeritin 87.95 µM -0.54925077478823 0.275514152105882 no 2399 0.291416681893554 3403 68077 A bioactive flavone.
SGTC_1518 st038567 90.8 µM -0.551424694825572 0.274748855915144 no 2400 0.290671287993172 3441 77966
SGTC_2882 9058044 58.44 µM -0.551476529906188 0.274730620947725 no 2401 0.290653525666598 3405 18076804
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.551647260360362 0.274670564216079 no 2402 0.290595025054036 3389 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1367 1812-0510 76.9 µM -0.552006482366674 0.274544224194275 no 2403 0.290471955999796 3398 1142582 YDR527W RBA50
SGTC_2734 clemastine 41.6 µM -0.553521141855323 0.274011827048122 no 2404 0.289953303855041 3373 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2403 6032726 181.2 µM -0.553705029920949 0.273947225829259 no 2405 0.289890366178537 3391 2881040
SGTC_1273 0849-0096 14.1 µM -0.553778421387869 0.273921444973618 no 2406 0.289865248945352 3411 5286025
SGTC_2486 5283202 22.39 µM -0.554417619627368 0.273696959001121 no 2407 0.289646535197575 3364 1377751
SGTC_552 k242-0005 476 µM -0.554598975679242 0.273633283460818 no 2408 0.289584494909841 3474 4088318
SGTC_1974 st069448 26.9 µM -0.555986002835855 0.273146529822711 no 2409 0.289110211745453 3442 6323587 YNR016C ACC1
SGTC_1510 1123-0200 71.5 µM -0.556342927564993 0.273021342595723 no 2410 0.288988223227672 3551 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2585 alliin 100 µM -0.556761538211623 0.272874555995831 no 2411 0.28884518276995 3542 87310 A garlic compound which reacts with lipids.
SGTC_1214 0358-0031 63.7 µM -0.557524583787498 0.272607093385849 no 2412 0.288584533680761 3509 4301366
SGTC_3047 9092122 49.47 µM -0.558644120789491 0.272214909131698 no 2413 0.288202311201145 3399 17173831
SGTC_704 1310-0270 142 µM -0.559613591513411 0.271875521191401 no 2414 0.287871516091996 3431 5718033
SGTC_192 3455-0609 60.9 µM -0.559954172453758 0.271756342139342 no 2415 0.287755348341223 3497 3769639
SGTC_289 k017-0060 526 µM -0.562117096402657 0.271000080365593 no 2416 0.28701812041467 3382 5512909
SGTC_2943 9068529 45.32 µM -0.562545893505922 0.270850277166476 no 2417 0.286872072177205 3488 3270634
SGTC_1319 1306-0155 43.7 µM -0.564844071429697 0.270048098024335 no 2418 0.286089913852802 3452 3122360
SGTC_1645 Cervolide 78 µM -0.566440410316335 0.269491596316893 no 2419 0.285547215355186 3432 23173 A fragrance.
SGTC_1388 3346-4487 254 µM -0.567450293455916 0.269139836755731 no 2420 0.285204144218344 3456 3345614
SGTC_2951 9072950 58.06 µM -0.568089381201183 0.268917350652702 no 2421 0.28498713888678 3499 16488155
SGTC_175 3793-3120 23.7 µM -0.568312563522843 0.268839675781814 no 2422 0.284911374805679 3381 5322297
SGTC_1942 st076330 65.2 µM -0.569050758228711 0.268582839765145 no 2423 0.284660847065253 3531 24208414
SGTC_3245 9134821 49.47 µM -0.570499941334992 0.268078992418172 no 2424 0.284169330946157 3396 17014901
SGTC_2430 5571206 200 µM -0.571825628319748 0.267618498871685 no 2425 0.283720056456187 3519 1731771
SGTC_1545 lovastatin 49.4 µM -0.574063211245047 0.266842152686927 no 2426 0.28296251354544 3473 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_251 melphalan 456.522 µM -0.575339113247676 0.26639997890922 no 2427 0.282530986852711 3485 460612 A DNA alkylator.
SGTC_2167 5876490 200 µM -0.576234023736616 0.266090062055741 no 2428 0.282228505370678 3512 686534
SGTC_12 0849-0099 9.267 µM -0.576970618609586 0.265835108618553 no 2429 0.281979651868937 3447 6071388
SGTC_1860 st056228 74.6 µM -0.578587656918272 0.265275846810241 no 2430 0.281433717601764 3470 688679
SGTC_1526 st051518 75 µM -0.579492402412335 0.264963196284092 no 2431 0.281128485813878 3385 673993
SGTC_679 0422-0091 41.4 µM -0.581240382238892 0.264359682282521 no 2432 0.280539227398646 3468 627384 YHR062C RPP1
SGTC_2866 9034245 58.44 µM -0.581435781270442 0.264292261598886 no 2433 0.28047339393557 3439 6462273
SGTC_1664 st014217 9.02 µM -0.582262696715198 0.26400703879507 no 2434 0.280194874003564 3550 3982782
SGTC_3330 9141424 71.43 µM -0.582335271914612 0.263982013372499 no 2435 0.280170435774511 3484 27261020
SGTC_527 4476-4215 268 µM -0.583479791883123 0.263587519260006 no 2436 0.279785178474804 3383 4418754
SGTC_165 k038-0023 64.381 µM -0.583544805984773 0.263565119176585 no 2437 0.279763301770068 3432 46368543
SGTC_763 3453-1109 128 µM -0.584084923718954 0.263379063538403 no 2438 0.279581588736764 3532 1560353
SGTC_3004 9076122 71.4286 µM -0.584491767750218 0.263238961301493 no 2439 0.279444751122809 3501 44782551
SGTC_581 0958-0271 211 µM -0.584898624761059 0.263098892672648 no 2440 0.279307941680574 3437 4591145
SGTC_2950 9072895 21.46 µM -0.585345385711906 0.26294513019962 no 2441 0.279157751667419 3483 17332245
SGTC_354 2783-3500 4.88 µM -0.586198360117144 0.262651688192994 no 2442 0.278871111790159 3426 6740761
SGTC_72 0744-0168 198.391 µM -0.58650416001146 0.262546527104019 no 2443 0.278768383400458 3371 677577
SGTC_1160 4092-0570 10.5 µM -0.586941657506818 0.262396114194245 no 2444 0.278621445425802 3496 4994975
SGTC_1616 st002734 56.1 µM -0.588100087271861 0.261998055885373 no 2445 0.278232557280252 3431 4026101
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.588483219529265 0.261866472575783 no 2446 0.278103996964534 3522 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2760 etidronate 98.04 µM -0.588690720011164 0.261795222562602 no 2447 0.278034382120761 3448 3305 A chelator and antioxidant.
SGTC_2125 5246583 200 µM -0.590299369523837 0.261243193722197 no 2448 0.27749498100107 3568 835267
SGTC_1837 st055472 66.5 µM -0.593285221487804 0.260220147726532 no 2449 0.276495143701737 3578 676091
SGTC_699 0375-0592 111 µM -0.59334241704175 0.260200570919086 no 2450 0.276476008551126 3542 762578
SGTC_1272 0839-0021 27 µM -0.593756682731805 0.260058799349531 no 2451 0.276337432613778 3495 5027250
SGTC_1366 1683-0113 21.9 µM -0.593909017998933 0.260006676616093 no 2452 0.276286483542279 3486 708623
SGTC_2434 5670830 169.91 µM -0.594521204225651 0.259797266526941 no 2453 0.276081782172189 3481 1549830
SGTC_1934 st074720 32.6 µM -0.595961535127667 0.259304917071335 no 2454 0.275600461644391 3502 17250992
SGTC_2741 miltefosine 3.04 µM -0.596337434859053 0.259176502349009 no 2455 0.275474913815239 3424 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2873 9040596 71.43 µM -0.596450015475795 0.259138048999932 no 2456 0.27543731816769 3520 6463863
SGTC_2096 5468907 200 µM -0.596504802635435 0.259119336812067 no 2457 0.275419023224919 3496 759785
SGTC_871 0574-0004 149 µM -0.596610508212831 0.259083235753519 no 2458 0.275383726908557 3402 9551173
SGTC_925 2064-1272 59.6 µM -0.597302258890618 0.258847050070675 no 2459 0.275152798304244 3424 6815817
SGTC_1454 4239-0054 42.6 µM -0.601130209072519 0.257542083011005 no 2460 0.273876632027565 3615 1340767
SGTC_579 4491-1009 110 µM -0.601347793332138 0.25746801023283 no 2461 0.273804181534575 3631 1271041
SGTC_2834 9001755 58.44 µM -0.60141622206729 0.257444717147552 no 2462 0.273781398318039 3390 2989575
SGTC_1165 k072-0275 30.3 µM -0.601813237237357 0.257309595115559 no 2463 0.27364923137905 3568 6153523 YGL055W OLE1
SGTC_1191 1487-1166 10.6 µM -0.602437251637535 0.25709728960675 no 2464 0.273441559880619 3541 3955771
SGTC_1326 1431-2094 10.8 µM -0.60293127271372 0.256929275752916 no 2465 0.273277205413379 3481 616278
SGTC_1002 4049-0206 172 µM -0.603460802508069 0.256749249035058 no 2466 0.273101092003512 3521 4662749
SGTC_729 4092-0585 94.1 µM -0.60510922174135 0.256189248921782 no 2467 0.27255321365298 3462 2169061
SGTC_2382 9035899 200 µM -0.605211631811446 0.25615447925102 no 2468 0.272519194049071 3532 6462679
SGTC_2221 6807166 181.081 µM -0.605600872665879 0.256022348916372 no 2469 0.272389911357695 3489 674925
SGTC_796 1234-0020 70.7 µM -0.60684710430001 0.255599546771033 no 2470 0.271976192254841 3499 46495034
SGTC_2380 9035439 200 µM -0.608179122281445 0.255148043896097 no 2471 0.271534339947776 3603 6462575
SGTC_3168 9103419 49.47 µM -0.60842562483354 0.255064534769958 no 2472 0.271452610209999 3493 16649256
SGTC_2726 cimetidine 79.27 µM -0.609643068725618 0.254652303885423 no 2473 0.271049137529326 3505 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2945 9067681 61.76 µM -0.610215390457183 0.254458634325277 no 2474 0.270859567988608 3595 16456930
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.610479555767034 0.254369268723926 no 2475 0.270772091108872 3520 688788
SGTC_764 1951-2361 146 µM -0.61149214960807 0.254026866506613 no 2476 0.270436906965967 3448 5438930
SGTC_1154 4088-0362 150 µM -0.612262212204564 0.25376663666287 no 2477 0.270182143274654 3539 6618304
SGTC_1217 1183-1422 255 µM -0.61253254346222 0.253675315915085 no 2478 0.270092736694953 3551 2849664
SGTC_700 3453-2283 142 µM -0.613856641272077 0.253228271134428 no 2479 0.269655032107289 3592 565664
SGTC_2743 auranofin 4.32 µM -0.61478016057783 0.252916715946362 no 2480 0.269349956511721 3488 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1022 4477-0945 21.3 µM -0.616241463236206 0.252424148547639 no 2481 0.268867583267299 3523 4648966
SGTC_2210 7115885 190.385 µM -0.617224655783535 0.25209302446577 no 2482 0.2685432775682 3548 2927039
SGTC_2556 citropten 84.59 µM -0.617239095677498 0.252088163040186 no 2483 0.26853851604002 3474 2775 A potential DNA crosslinker.
SGTC_3254 9136651 49.47 µM -0.617333475897969 0.252056389619199 no 2484 0.268507395383063 3510 16454030
SGTC_1671 st016596 74.5 µM -0.617842803895023 0.25188495909687 no 2485 0.268339482362792 3580 2829167
SGTC_297 0986-0032 24 µM -0.619398345708096 0.25136177331052 no 2486 0.267826985344236 3501 2847425
SGTC_1709 st033179 39.1045 µM -0.61990550233368 0.251191322188004 no 2487 0.267660001496298 3537 573381
SGTC_2185 6113692 200 µM -0.621433478301387 0.250678151927928 no 2488 0.267157225195805 3548 874150
SGTC_2362 9071156 126 µM -0.621823032252498 0.250547409234571 no 2489 0.267029119843724 3569 653133
SGTC_1357 1503-1303 39.5 µM -0.622351527678129 0.250370092562403 no 2490 0.266855373000184 3553 292895
SGTC_2708 st078559 56 µM -0.622977326376451 0.250160215503155 no 2491 0.266649710862569 3501 17250902
SGTC_2701 st077767 14.721 µM -0.623261101926206 0.250065075119638 no 2492 0.26655647743753 3541 5721188
SGTC_1432 4049-0298 68.4 µM -0.623432914619623 0.250007481441851 no 2493 0.266500037015111 3565 741646
SGTC_20 0481-0013 4.944 µM -0.624145562683092 0.249768668417861 no 2494 0.266265996873575 3540 182045
SGTC_738 1315-0003 72.4 µM -0.624394233701122 0.249685365650251 no 2495 0.266184355527765 3562 6251474
SGTC_1255 0566-0045 221 µM -0.624524853254512 0.249641615074359 no 2496 0.266141476813538 3577 2788469
SGTC_2061 5245884 80.95 µM -0.626501261392861 0.248980121116919 no 2497 0.26549310489504 3540 573863
SGTC_1633 st005664 67.9 µM -0.626545508126767 0.248965322637546 no 2498 0.265478598679006 3545 2063822
SGTC_1522 st012842 45.6 µM -0.627138527671103 0.248767030301466 no 2499 0.265284217055734 3506 3491067 YOR116C RPO31
SGTC_1930 st074634 34.3 µM -0.628986757617757 0.248149563814016 no 2500 0.264678862872521 3549 684253 YOR116C RPO31
SGTC_2725 haloperidol 53.21 µM -0.629428795043897 0.248002006826275 no 2501 0.264534185708957 3534 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1237 0330-0133 46.1 µM -0.630195542008031 0.247746169274912 no 2502 0.264283327816875 3521 X1237 YHR072W ERG7
SGTC_1017 4239-0030 168 µM -0.632112694258424 0.247107097541571 no 2503 0.263656620410444 3510 1149593
SGTC_2687 chenodiol 100 µM -0.634124436791001 0.246437443964095 no 2504 0.262999808058724 3580 5702181 A cholesterol synthesis inhibitor.
SGTC_3212 9128307 49.47 µM -0.634171618982504 0.246421749994522 no 2505 0.26298441362298 3441 27243542
SGTC_2650 prasterone 100 µM -0.636846923139727 0.245532754183917 no 2506 0.262112279146018 3530 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2543 pimpinellin 60.67 µM -0.637341375031495 0.245368638101965 no 2507 0.261951252984923 3511 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2406 ethylparaben 405.7 µM -0.638471407071428 0.244993784775788 no 2508 0.261583430509294 3382 8434 A possible steroid mimic.
SGTC_1450 4112-4260 37.6 µM -0.638872903950544 0.244860674768849 no 2509 0.261452808181947 3583 1633175
SGTC_886 0866-0150 153 µM -0.639118415505731 0.244779298436547 no 2510 0.261372950365993 3626 271463
SGTC_3298 9116858 71.43 µM -0.639401209486218 0.244685582657831 no 2511 0.261280981182466 3601 2506942
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.640523985506673 0.244313693904866 no 2512 0.26091600034211 3557 115019
SGTC_2447 5741742 33.78 µM -0.640946467403121 0.244173837293715 no 2513 0.260778732064128 3601 1776504
SGTC_2924 9010168 62.78 µM -0.641605145403234 0.243955877472873 no 2514 0.260564795632515 3595 2993929
SGTC_3171 9103192 49.47 µM -0.643699164347388 0.243263654062713 no 2515 0.259885265959368 3625 13018434
SGTC_2195 6536160 144.242 µM -0.643918905700658 0.243191075391218 no 2516 0.259814010772362 3466 3834386
SGTC_2070 5230947 200 µM -0.645079553187987 0.242807917842851 no 2517 0.259437816717838 3649 2835538
SGTC_1479 0549-0158 134 µM -0.645731694926313 0.242592773669839 no 2518 0.259226565258347 3625 5440202
SGTC_2346 9031566 143.75 µM -0.645732818194955 0.242592403188089 no 2519 0.259226201469162 3533 4771086
SGTC_1812 st052057 4.327 µM -0.646013579624103 0.242499810741813 no 2520 0.259135280498723 3595 3645418
SGTC_2658 polymyxin b sulfate 77.05 µM -0.646355739107925 0.242386995685453 no 2521 0.259024498852555 3563 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1961 st076550 68.7 µM -0.647613884321258 0.241972411179463 no 2522 0.258617357423078 3574 1579337
SGTC_1909 st060837 51.5 µM -0.647887470193325 0.241882309995566 no 2523 0.258528867689344 3542 678937
SGTC_3027 9089541 49.47 µM -0.648313382391396 0.241742078776694 no 2524 0.258391140120063 3585 9943819
SGTC_1839 st053978 48 µM -0.648386090892666 0.241718143976279 no 2525 0.258367632112977 3634 3788398
SGTC_3013 9080133 71.4286 µM -0.648916327057332 0.241543635243653 no 2526 0.258196230440207 3669 17050193
SGTC_1805 st050013 60.3 µM -0.649697575535095 0.241286639278754 no 2527 0.257943795148307 3550 4037144
SGTC_756 0508-1999 28.3 µM -0.650016965832841 0.241181616897205 no 2528 0.257840631341012 3553 6753853
SGTC_734 2023-0417 80 µM -0.650569528741667 0.240999981053093 no 2529 0.257662202817101 3566 3935732
SGTC_1771 st048882 4.1505 µM -0.650646060129462 0.240974829886786 no 2530 0.257637495061897 3533 4580403
SGTC_119 0121-0043 24.815 µM -0.651043540855255 0.240844225350749 no 2531 0.257509190294365 3673 1092378
SGTC_631 k072-0230 41.5 µM -0.651128953241856 0.240816165507878 no 2532 0.257481623940987 3596 5773147
SGTC_1279 0874-0590 65.2 µM -0.651939250715194 0.240550053512256 no 2533 0.257220181397781 3597 3523074
SGTC_2791 5663188 71.43 µM -0.652500529126704 0.24036581645027 no 2534 0.257039165813878 3582 54690634
SGTC_2263 7948595 193.29 µM -0.653418576268155 0.240064637449308 no 2535 0.256743233103237 3583 2971371
SGTC_2384 9036245 200 µM -0.654087541184614 0.239845303219741 no 2536 0.256527703872416 3588 6462766
SGTC_2196 6573537 42.6665 µM -0.655252875891135 0.239463484922228 no 2537 0.256152477869093 3637 2903087
SGTC_2268 7933382 153.85 µM -0.655635767498539 0.239338104157943 no 2538 0.256029253137596 3636 935025 YOR257W CDC31
SGTC_2817 7995342 71.43 µM -0.657035202819119 0.238880153629329 no 2539 0.255579140715878 3553 18879975
SGTC_462 ag-879 158 µM -0.657625946262659 0.238686982973846 no 2540 0.255389258961338 3619 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1052 3253-3998 198 µM -0.658499240607493 0.238401575987398 no 2541 0.255108692419086 3592 5450317
SGTC_542 3381-0244 89.3 µM -0.660384623685371 0.237786039470133 no 2542 0.25450351851849 3624 1112843
SGTC_2874 9043904 71.43 µM -0.660493934143022 0.237750378740247 no 2543 0.254468454919906 3549 4463428
SGTC_1064 honokiol 6.76 µM -0.660998009667397 0.237585970394519 no 2544 0.254306794987217 3614 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1088 bifonazole 369 nM -0.661160836006848 0.237532876589886 no 2545 0.254254587146169 3567 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3249 9135183 49.47 µM -0.661338201223306 0.237475049413547 no 2546 0.254197724025978 3639 4902779
SGTC_1629 st005085 44.9 µM -0.661623687509945 0.237381987272394 no 2547 0.254106211401047 3606 24207091
SGTC_2226 7298446 200 µM -0.662004986980976 0.237257723415729 no 2548 0.253984012820056 3616 3283010
SGTC_1359 1582-0056 520 nM -0.662698523844352 0.237031794357181 no 2549 0.253761827696228 3641 3661189
SGTC_2223 6903751 107.57 µM -0.662958683429964 0.23694707434148 no 2550 0.253678507929236 3589 5598863
SGTC_2785 7756463 72.73 µM -0.663569984395834 0.236748071943812 no 2551 0.253482786750921 3600 2201551
SGTC_1293 1000-1278 195 µM -0.66562044851805 0.236081237342611 no 2552 0.252826866366932 3662 678847
SGTC_2939 9044578 71.43 µM -0.665669484388561 0.236065302990776 no 2553 0.252811191290891 3606 2653634
SGTC_2320 7373003 200 µM -0.66580060314075 0.236022698473371 no 2554 0.252769279662738 3620 5415828
SGTC_2931 9014674 55.67 µM -0.666245202715665 0.235878265935641 no 2555 0.25262719227797 3620 2996810
SGTC_770 0389-1121 67.2 µM -0.666286056443433 0.235864996645564 no 2556 0.252614138147505 3686 6753108
SGTC_1243 0416-0003 5.65 µM -0.666440497264951 0.235814837987644 no 2557 0.252564792357734 3604 2141977
SGTC_1885 st057546 99.9 µM -0.667571215233607 0.235447787231616 no 2558 0.252203668458175 3664 702008
SGTC_2016 5121758 140 µM -0.667621049945109 0.235431617273174 no 2559 0.25218775872728 3619 2795203
SGTC_73 0327-0325 16.231 µM -0.668541741755825 0.235132989025195 no 2560 0.251893923127321 3658 53298
SGTC_853 0419-0306 21 µM -0.6690198983255 0.234977980553372 no 2561 0.251741392440726 3568 762713
SGTC_751 0833-0568 350 µM -0.670290256095596 0.234566431234619 no 2562 0.251336388694499 3653 6954252
SGTC_1870 st057514 26.5 µM -0.670758301142101 0.234414902373906 no 2563 0.251187257770875 3631 5393161
SGTC_3327 9140648 26.9345 µM -0.672469669862403 0.233861310755739 no 2564 0.250642371291847 3618 8029710
SGTC_2671 danthron 100 µM -0.675015908311876 0.233038998855339 no 2565 0.249832828950263 3606 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2808 7946468 45.46 µM -0.675679124963518 0.232825075822528 no 2566 0.249622196213204 3630 2970879
SGTC_2779 methotrexate 400 µM -0.676438202536632 0.232580366449485 no 2567 0.249381234568099 3694 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1120 ficusin 1.78878 µM -0.676983167647265 0.232404770290507 no 2568 0.249208317075411 3682 6199 A DNA cross-linker.
SGTC_3044 9093193 49.47 µM -0.679826189158227 0.231489901736813 no 2569 0.248307260985085 3617 25236277
SGTC_1153 4055-0057 267 µM -0.680587377796299 0.231245296650404 no 2570 0.248066307952574 3651 882706
SGTC_648 0375-0473 33.3 µM -0.681550801540973 0.230935910924826 no 2571 0.247761516666549 3651 1713139
SGTC_928 2764-0428 58.7 µM -0.682611886255652 0.230595430777083 no 2572 0.247426060619182 3662 662578
SGTC_2283 7944793 200 µM -0.684363130594384 0.230034106685454 no 2573 0.246872945762958 3636 2970533
SGTC_2472 5377652 49.4 µM -0.685766371572299 0.229584880021575 no 2574 0.246430222719244 3665 1610903
SGTC_1665 st014639 11.4 µM -0.685844767440516 0.229559797258329 no 2575 0.246405501349245 3713 981133 YIL048W NEO1
SGTC_1901 st060216 58.6 µM -0.687108126028782 0.229155797390827 no 2576 0.246007296935587 3665 688792
SGTC_2208 7283366 200 µM -0.687368931365427 0.229072446112976 no 2577 0.24592513539142 3662 898663
SGTC_2524 avocatin b 10.57 µM -0.687472137630945 0.229039466921812 no 2578 0.245892626373201 3598 6710748
SGTC_1091 telmisartan 47.6 µM -0.687856822286445 0.228916565793099 no 2579 0.245771474589881 3724 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2784 7567673 72.73 µM -0.688881181904116 0.228589478410361 no 2580 0.245449021252541 3677 3471247
SGTC_3214 9129694 49.47 µM -0.691299033358434 0.227818478305672 no 2581 0.244688819579845 3627 17158655
SGTC_347 4534-1311 26.2 µM -0.691825834224352 0.2276506873642 no 2582 0.244523355393541 3677 2862016
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.692966201324412 0.227287708327087 no 2583 0.244165381227098 3628 390807
SGTC_194 1486-1323 56.904 µM -0.693720854496434 0.227047681526392 no 2584 0.243928642503834 3651 5178754
SGTC_2738 aclarubicin 5.55 µM -0.694381870201271 0.226837554755598 no 2585 0.243721380148188 3580 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2847 9005661 71.43 µM -0.694900991352808 0.226672611027644 no 2586 0.243558675693947 3592 2991449
SGTC_3205 9113483 49.47 µM -0.695456429418987 0.226496203072787 no 2587 0.243384653672491 3675 17018033
SGTC_2327 6189656 200 µM -0.698242807314834 0.225612416039295 no 2588 0.242512679860594 3720 5349088
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.700103751473731 0.225023247801232 no 2589 0.241931256593763 3695 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1995 st072814 61.1 µM -0.70032287129957 0.224953932672803 no 2590 0.241862845783619 3643 5769371
SGTC_1506 4226-2149 212 µM -0.700499139498459 0.224898181770443 no 2591 0.241807821182936 3701 991114
SGTC_2246 7293507 91.5585 µM -0.701211456761428 0.224672966644194 no 2592 0.241585530526713 3722 887656
SGTC_1915 st067105 30.6 µM -0.702456508623958 0.224279622854671 no 2593 0.241197257632084 3672 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1220 1838-0075 193 µM -0.702633706283654 0.224223673371842 no 2594 0.241142025632768 3636 5529645
SGTC_3026 9090633 49.47 µM -0.702818055567132 0.224165474203598 no 2595 0.241084571791082 3685 25236842
SGTC_2296 7971656 126.45 µM -0.704617579996015 0.223597814157637 no 2596 0.240524127571821 3728 666570
SGTC_1339 1486-1321 22.7 µM -0.706013828739246 0.223157931242452 no 2597 0.240089768843846 3719 3469382
SGTC_1991 st073000 8.92 µM -0.706041608848266 0.223149184225235 no 2598 0.240081131076342 3738 4301969 YIL048W NEO1
SGTC_2661 dactinomycin 12.96 µM -0.706617394668621 0.222967932690619 no 2599 0.239902138106717 3701 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2745 rifampicin 24.3 µM -0.70685489187861 0.222893195412736 no 2600 0.239828329204284 3619 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1676 st018489 23.4 µM -0.707537033751287 0.222678613633414 no 2601 0.239616403438309 3723 3696235
SGTC_2115 tiliquinol 12.7705 µM -0.708599084775424 0.222344758097117 no 2602 0.239286652215112 3686 71208 A bioactive hydroxyquinoline.
SGTC_2995 9067767 71.4286 µM -0.709267669905875 0.222134735028571 no 2603 0.239079193589595 3688 11673567
SGTC_1803 st050068 52.4 µM -0.709510226648984 0.222058568525734 no 2604 0.239003953755395 3775 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1863 st057641 20.1 µM -0.709588652674341 0.222033944752053 no 2605 0.238979629181972 3704 3921635
SGTC_3227 9130768 49.47 µM -0.709959071542578 0.22191766373658 no 2606 0.238864758563536 3702 17720899
SGTC_1455 4262-0120 131 µM -0.710248083788017 0.221826961852595 no 2607 0.23877515393481 3748 1529587
SGTC_456 gingerol 170 µM -0.711392152351891 0.221468122066469 no 2608 0.238420630332365 3731 442793 A herb.
SGTC_2015 5119600 184 µM -0.711686505722786 0.221375851145211 no 2609 0.238329462844207 3692 2828786
SGTC_1841 st054148 70 µM -0.712618424518629 0.221083867667264 no 2610 0.238040953762606 3689 675442
SGTC_3184 9108758 49.47 µM -0.713482593270141 0.220813308278245 no 2611 0.237773590303876 3702 902885
SGTC_1638 st008370 60.6 µM -0.714584510185385 0.220468588365612 no 2612 0.237432909466626 3704 24207134
SGTC_2647 atorvastatin 60.16 µM -0.714674025491409 0.220440598255159 no 2613 0.237405245697062 3687 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1969 st069479 40.1 µM -0.714999024148079 0.220338993110504 no 2614 0.237304823136879 3661 3895485
SGTC_1274 0865-0114 173 µM -0.715514034969775 0.220178038979584 no 2615 0.237145735786741 3713 870624
SGTC_2443 5493264 126.67 µM -0.715844968799025 0.220074649239041 no 2616 0.237043540931784 3721 5340055
SGTC_2000 st075254 36.4 µM -0.71597692796629 0.220033430565645 no 2617 0.237002797698999 3661 17234175
SGTC_595 3909-8003 73.7 µM -0.716020880271858 0.220019702637475 no 2618 0.236989227999446 3755 699517
SGTC_2843 9000894 45.46 µM -0.718048612534097 0.219386901447607 no 2619 0.236363656703847 3601 2242070
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.721062090737007 0.218448409870993 no 2620 0.235435656853017 3701 6708760
SGTC_1353 1498-1206 8.11 µM -0.721184174970138 0.218410437809233 no 2621 0.235398103471716 3749 6756808
SGTC_2518 prenyletin 46.28 µM -0.722276966755426 0.218070714322468 no 2622 0.235062105572986 3652 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_113 0099-0221 2.5 µM -0.722649328499208 0.217955025353491 no 2623 0.234947677004135 3715 89219
SGTC_861 0443-0273 110 µM -0.724629085318216 0.217340529801237 no 2624 0.2343398053068 3739 6149169
SGTC_2350 9023895 38.85 µM -0.725465171688337 0.217081318209137 no 2625 0.234083351975195 3731 2997209
SGTC_1053 3366-3204 134 µM -0.725490640362327 0.217073424968823 no 2626 0.234075542391982 3719 3632071 YPR165W RHO1
SGTC_613 3914-0030 117 µM -0.725518539476932 0.21706477867775 no 2627 0.234066987716568 3486 1145395
SGTC_939 1165-0479 45.3 µM -0.725956834568414 0.216928971567519 no 2628 0.233932616495501 3662 1377347
SGTC_2860 9025725 38.96 µM -0.727693791859816 0.216391253125139 no 2629 0.233400525739964 3720 40546248
SGTC_512 prima-1 270 µM -0.729738726893667 0.215759182318684 no 2630 0.232774952138354 3730 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1769 st044406 64.4 µM -0.7302156916809 0.215611910908414 no 2631 0.232629176201153 3737 670903
SGTC_1188 1403-0014 4.57 µM -0.730437907960948 0.215543317566147 no 2632 0.232561277018932 3756 9614867
SGTC_49 0717-0965 32.132 µM -0.7305008868139 0.215523879663135 no 2633 0.232542035551752 3798 5889349 YGL099W LSG1
SGTC_890 0929-0006 47.2 µM -0.730723656233735 0.215455131879638 no 2634 0.232473981547856 3713 1378169
SGTC_638 3970-0837 4.09 µM -0.73124798923426 0.215293370245988 no 2635 0.232313846372487 3716 4118451 YLR208W SEC13
SGTC_662 k832-1615 104 µM -0.732150726126189 0.215015032658918 no 2636 0.232038287688235 3758 5878478
SGTC_2914 7968218 45.32 µM -0.734146560793694 0.214400406410266 no 2637 0.231429709410366 3700 2977111
SGTC_3219 9131112 49.47 µM -0.734939927577653 0.214156369624189 no 2638 0.231188040123654 3681 17612988 YMR079W SEC14
SGTC_322 k048-0136 19.3 µM -0.736324317812718 0.213730923441917 no 2639 0.230766675234503 3754 6823282
SGTC_2150 5556613 200 µM -0.736419050324677 0.213701828570178 no 2640 0.23073785732376 3733 743190
SGTC_889 0919-1524 82.7 µM -0.738038743645592 0.213204734753241 no 2641 0.230245452940623 3775 3905452
SGTC_3332 9141069 11.198 µM -0.738671844378345 0.213010615708737 no 2642 0.230053143309717 3690 17332883
SGTC_1449 4112-4002 201 µM -0.739773240035003 0.212673155637036 no 2643 0.229718799480001 3741 2059539
SGTC_1514 1189-1591 158 µM -0.740171083858966 0.212551335809029 no 2644 0.229598095441112 3749 767698 YMR146C TIF34
SGTC_2654 protoveratrine a 100 µM -0.740513719295388 0.212446453469431 no 2645 0.229494169863494 3724 5702278 A heart drug and vasodilator.
SGTC_1722 st034304 3.6505 µM -0.741673289910459 0.212091727771113 no 2646 0.229142653344307 3766 4036148 YLR033W RSC58
SGTC_1680 diphenhydramine 100 µM -0.742958022384601 0.211699118358928 no 2647 0.228753547673689 3773 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_624 k048-0052 28 µM -0.743214918766904 0.211620662852581 no 2648 0.228675786244763 3726 6835531
SGTC_2237 6667747 47.222 µM -0.744212166901657 0.211316267109184 no 2649 0.228374064218167 3705 729940 YDL015C TSC13
SGTC_1246 0422-0085 105 µM -0.745075636854896 0.211052912546856 no 2650 0.22811299820923 3742 264295
SGTC_1106 tegaserod maleate 11.7 µM -0.745445138354842 0.210940275006886 no 2651 0.228001332491925 3787 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2744 captopril 92.04 µM -0.747818247581974 0.210217705252381 no 2652 0.227284897004314 3701 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_786 4544-0069 423 µM -0.748294296154959 0.210072932136968 no 2653 0.227141332094976 3800 748821 YLR208W SEC13
SGTC_491 tetrandrine 80.3 µM -0.748718841986778 0.209943871161215 no 2654 0.22701334231868 3721 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_100 0086-0128 49.5915 µM -0.749261704175945 0.209778910184312 no 2655 0.22684974243073 3751 93297
SGTC_227 fluconazole 33.516 µM -0.749535125607607 0.209695853750834 no 2656 0.226767367859812 3744 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2960 9079389 5.97 µM -0.749808507061773 0.209612828796661 no 2657 0.226685022209372 3723 16457355
SGTC_1062 mesoridazine 14.2 µM -0.7503128082175 0.209459725104251 no 2658 0.226533165163912 3759 4078 A neuroleptic.
SGTC_1468 k284-1086 134 µM -0.751178674740451 0.209197005216401 no 2659 0.226272566214013 3757 15996457
SGTC_2489 cantharidin 73.42 µM -0.753726605573804 0.208425042154585 no 2660 0.225506701353042 3741 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1402 3909-7673 35.9 µM -0.755928376152499 0.207759312649697 no 2661 0.224846069828053 3768 5328014
SGTC_56 0957-0365 83.25 µM -0.756303551350531 0.207645999686261 no 2662 0.224733609682111 3718 6752360
SGTC_3305 9127027 53.8275 µM -0.757153905319275 0.207389305212903 no 2663 0.224478831073535 3700 41905295
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.759365033397644 0.206722715592962 no 2664 0.2238171122183 3793 521171
SGTC_1306 1185-0270 9.02 µM -0.759427522085246 0.206703895555698 no 2665 0.223798427506187 3783 1548076
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.762821976248046 0.205683095613113 no 2666 0.22278478651112 3813 23665772 A membrane-active detergent.
SGTC_1570 verbenone 133 µM -0.765516615403105 0.204874882520446 no 2667 0.221981988158615 3778 29025 A natural terpanoid with antifungal properties.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.766148289541136 0.204685695740973 no 2668 0.221794036377954 3837 6708561
SGTC_1818 st052136 56.3 µM -0.7672879774338 0.204344621561005 no 2669 0.221455157476091 3649 674169
SGTC_522 1273-0010 11.6 µM -0.768687442700082 0.203926267018936 no 2670 0.221039440633397 3863 5705015
SGTC_2602 kawain 100 µM -0.770182376381812 0.20347993754367 no 2671 0.220595858262548 3740 5369129
SGTC_2361 9034121 116 µM -0.770278034080922 0.203451397698681 no 2672 0.220567491720116 3788 6496917
SGTC_2955 9076254 12.21 µM -0.771375707025708 0.203124073678935 no 2673 0.220242135017348 3742 16459619
SGTC_1861 st057647 17.4 µM -0.77230998576046 0.202845721339416 no 2674 0.219965426245693 3829 688668
SGTC_1497 4476-2978 41.3 µM -0.77475930725519 0.202117070518732 no 2675 0.219240949426265 3822 1528379
SGTC_2241 6772625 37.8075 µM -0.775658957523591 0.201849826538645 no 2676 0.218975189610931 3714 2285411
SGTC_997 3996-0078 137 µM -0.775949259625781 0.201763636543311 no 2677 0.218889472919676 3840 735687
SGTC_1900 st060200 72.8 µM -0.778351520485207 0.201051257231915 no 2678 0.218180905222296 3782 688945
SGTC_1663 st014140 55.4 µM -0.779229255532728 0.200791345763374 no 2679 0.217922339734432 3859 4207120
SGTC_2318 6029776 164 µM -0.78102865635027 0.200259145092444 no 2680 0.217392820320316 3781 818325
SGTC_495 decylubiquinone 155 µM -0.781554998977267 0.200103631480613 no 2681 0.217238071175531 3813 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1305 1181-0477 144 µM -0.781880404280241 0.200007523293737 no 2682 0.217142431124708 3821 6252086
SGTC_2351 9026858 72.31 µM -0.782093094061657 0.199944720543492 no 2683 0.217079932502805 3749 1409300
SGTC_1005 4092-0690 4.4 µM -0.782699630071141 0.199765688549652 no 2684 0.216901759763297 3830 1529343
SGTC_3040 9091894 49.47 µM -0.783111716544872 0.199644107502914 no 2685 0.216780755711322 3713 25236966
SGTC_1562 morin hydrate 59.1 µM -0.783272600939127 0.199596652628291 no 2686 0.216733524612614 3865 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3228 9131799 49.47 µM -0.784100794850474 0.199352473853124 no 2687 0.216490484535787 3811 17015818
SGTC_1691 st019933 84.6 µM -0.784249661248692 0.199308602226383 no 2688 0.216446815236586 3767 6176082
SGTC_1693 xanthone 101.9 µM -0.784801832068663 0.199145925675356 no 2689 0.216284882896663 3851 7020 An insecticide.
SGTC_1048 3161-0300 24.5 µM -0.78601778452664 0.198787972724912 no 2690 0.21592853406176 3813 2165101
SGTC_864 0469-0573 172 µM -0.787032781611032 0.198489474396316 no 2691 0.215631338179117 3795 689425
SGTC_2375 9072683 200 µM -0.787140467105467 0.198457821272634 no 2692 0.215599821286373 3848 16798029
SGTC_1138 3761-0006 1.03 µM -0.787865123056237 0.198244894782257 no 2693 0.21538780181344 3780 12061087
SGTC_1087 pterostilbene 9.05 µM -0.788237942880409 0.198135402447318 no 2694 0.21527876951949 3858 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2993 9054257 71.4286 µM -0.789164249574873 0.197863516314445 no 2695 0.215008006999411 3789 6470217 YGL055W OLE1
SGTC_2488 5268135 45.7 µM -0.790330826761273 0.197521427724025 no 2696 0.214667294123343 3879 1270356 YLR208W SEC13
SGTC_1219 1469-0211 33.1 µM -0.790565583222944 0.197452630681835 no 2697 0.214598768624149 3798 6822282
SGTC_795 0685-0265 78 µM -0.790852664196688 0.197368519267578 no 2698 0.214514986864308 3853 302754
SGTC_2001 4023502 57.655 µM -0.791272587889253 0.197245525506826 no 2699 0.214392470521069 3841 108941 YCR052W RSC6
SGTC_2331 7980721 200 µM -0.791555733335749 0.19716261965801 no 2700 0.21430988338014 3791 2981221
SGTC_838 0109-0203 71.4 µM -0.791574282977404 0.197157189002464 no 2701 0.214304473513961 3822 759422
SGTC_2127 5253358 187.912 µM -0.793639208019606 0.196553220557223 no 2702 0.213702750108835 3765 20612
SGTC_2958 9077254 16.72 µM -0.793663337457308 0.196546169588058 no 2703 0.213695724563276 3843 16457351
SGTC_3195 9113082 49.47 µM -0.794081564295113 0.196423982033773 no 2704 0.213573974693851 3741 17018038
SGTC_1313 1220-0047 237 µM -0.79439943723434 0.196331144290611 no 2705 0.213481465852746 3816 3528706
SGTC_116 0155-0182 31.788 µM -0.794921449126369 0.19617874358975 no 2706 0.213329598232503 3774 771486
SGTC_1734 st037168 69.4 µM -0.795793436568498 0.195924328032883 no 2707 0.213076053631908 3884 708907
SGTC_1365 1672-3266 55.4 µM -0.796424954950113 0.195740198021205 no 2708 0.21289253915013 3822 6415873
SGTC_1935 st074532 41.6 µM -0.797027260465839 0.195564683417625 no 2709 0.212717599679198 3849 2829742
SGTC_3170 9103054 49.47 µM -0.797566898951168 0.195407511470182 no 2710 0.21256093314046 3844 16432970
SGTC_296 1222-0039 74.9 µM -0.800730909744608 0.194487524917491 no 2711 0.211643722115991 3822 5984176
SGTC_1681 tripelennamine 100 µM -0.800860857822889 0.194449796890917 no 2712 0.211606101228458 3801 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3210 9128157 49.47 µM -0.801664609792905 0.194216541347516 no 2713 0.21137349635326 3915 17590849
SGTC_708 3448-5400 146 µM -0.802193419426134 0.194063169351761 no 2714 0.211220541179589 3798 3462195
SGTC_2903 5923464 63.88 µM -0.803140618910216 0.193788635210492 no 2715 0.210946731298444 3855 2876576
SGTC_941 3237-0776 460 µM -0.808608611230364 0.192208437776077 no 2716 0.209370154999033 3870 760008
SGTC_1049 3226-0134 66 µM -0.808624748161097 0.192203786053542 no 2717 0.209365512552586 3881 5702385
SGTC_644 1498-1197 63.3 µM -0.810755123880505 0.191590276768671 no 2718 0.208753155125844 3920 6741615
SGTC_1534 6-azauridine 81.6 µM -0.810927680320714 0.191540636237457 no 2719 0.208703601573552 3878 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_343 4130-2827 29.8 µM -0.812406133474037 0.191115642200192 no 2720 0.208279313982808 3909 1118244
SGTC_2335 9018011 154.17 µM -0.812461008735595 0.191099878972849 no 2721 0.208263575640019 3885 6458208
SGTC_3321 9137793 26.8275 µM -0.813284629786125 0.190863384988124 no 2722 0.208027443661186 3824 4904192
SGTC_2626 ethyl orsellinate 100 µM -0.814229331741869 0.190592345118582 no 2723 0.207756792509265 3865 75653 A natural product.
SGTC_1669 st015249 58.4 µM -0.818858961238191 0.18926749977896 no 2724 0.206433443250754 3933 722793
SGTC_1891 st059073 26.2 µM -0.822438968726456 0.18824691850697 no 2725 0.205413554225445 3923 688754
SGTC_1261 0712-0010 12.7 µM -0.822720752954145 0.188166732438709 no 2726 0.205333405475699 3851 2840123
SGTC_2533 agelasine 13.65 µM -0.826936032349801 0.186969726718365 no 2727 0.204136659523726 3917 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2431 5490079 200 µM -0.827300193578155 0.186866538024147 no 2728 0.204033467043614 3932 5722345
SGTC_1259 0671-0132 43 µM -0.82780390522282 0.186723864437703 no 2729 0.203890781353924 3813 X1259
SGTC_449 xestospongin c 11.1929 µM -0.828529308488485 0.186518516420867 no 2730 0.203685401907935 3893 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1016 4226-1401 38 µM -0.829105108753046 0.186355617805771 no 2731 0.203522466587085 3852 2901613
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.829467678411383 0.186253089114408 no 2732 0.20341990944566 3869 2724 A muscle relaxant with antifungal properties.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.829791240620687 0.186161620604871 no 2733 0.203328412065328 3898 368090
SGTC_404 fumagillin 50 µM -0.830618075551207 0.185928007328711 no 2734 0.203094710101303 3859 12015870 A methionine aminopeptidase binder.
SGTC_1050 3232-1156 69.3 µM -0.832447933429449 0.185411647436012 no 2735 0.202578077784398 3866 700529
SGTC_2148 5546263 113.568 µM -0.832680915483569 0.1853459671575 no 2736 0.202512355297364 3874 792097
SGTC_589 1227-0070 34.1 µM -0.834820326123431 0.184743518622678 no 2737 0.201909439813206 3924 2841384
SGTC_2390 9097792 176.6 µM -0.835732541941743 0.184487013304643 no 2738 0.201652691905237 3906 4497149
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.835793732800323 0.184469815022284 no 2739 0.201635476420321 3868 688751
SGTC_144 4161-2749 112.381 µM -0.836477885245623 0.184277595275999 no 2740 0.201443056382133 3798 797501 YMR168C CEP3
SGTC_2753 fluvastatin 17.09 µM -0.837062027532517 0.184113573102465 no 2741 0.201278851639861 3937 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2685 mycophenolic acid 18.85 µM -0.837759762194545 0.183917774305676 no 2742 0.201082820828549 3865 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1103 duloxetine 36.1 µM -0.83822784981401 0.18378649192996 no 2743 0.200951374298399 3985 60835 A selective serotonin reuptake inhibitor.
SGTC_1416 3966-0321 25.3 µM -0.838322055289679 0.183760077612709 no 2744 0.200924926118933 3901 582530 YLR208W SEC13
SGTC_2921 7974240 10.71 µM -0.839618432604612 0.183396826004991 no 2745 0.20056118046024 3967 2979074 YDR527W RBA50
SGTC_2775 cyproheptadine 69.59 µM -0.840558091238182 0.183133808854319 no 2746 0.200297772511688 3890 2913 A selective serotonin reuptake inhibitor.
SGTC_1884 5633444 25 µM -0.840686587657879 0.183097860087175 no 2747 0.200261768169429 3920 5724239
SGTC_493 zm226600 134 µM -0.844068669707101 0.182153256042886 no 2748 0.199315516959447 3907 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2776 terbinafine 19.92 µM -0.845136171042673 0.181855740139157 no 2749 0.199017407472421 3916 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_819 1013-0258 27.7 µM -0.845710539838663 0.181695787626377 no 2750 0.198857120973917 3908 5753198
SGTC_1275 0867-0008 21.1 µM -0.846286139075777 0.181535580793391 no 2751 0.198696569192318 3860 3422836
SGTC_519 k048-0011 62.8 µM -0.846754479590691 0.181405292592729 no 2752 0.198565992755966 3980 6836379
SGTC_664 1222-0054 14.9 µM -0.847158322336301 0.181292994119148 no 2753 0.19845344029294 3859 6813991
SGTC_137 0438-0332 85.389 µM -0.848502222622612 0.180919602945733 no 2754 0.198079167588949 3894 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1298 1079-1278 263 µM -0.848590335043524 0.180895138512258 no 2755 0.198054643408631 3920 2840950
SGTC_1446 4239-0190 62 µM -0.850754066343675 0.180295028742452 no 2756 0.19745299125985 3915 1340085
SGTC_2445 5742597 35.57 µM -0.851159731926575 0.180182656826491 no 2757 0.197340314095683 3869 1774255
SGTC_1649 st011737 51.3 µM -0.851296631077136 0.180144744824525 no 2758 0.197302297937467 3886 1761035
SGTC_1776 st049249 45.9 µM -0.851787798781249 0.180008765101239 no 2759 0.197165939768691 3956 1822314
SGTC_2035 5154463 94.595 µM -0.856502119268822 0.17870688580663 no 2760 0.195860050553892 3935 2769623
SGTC_857 0438-0306 1.35 µM -0.856800832665012 0.178624595055598 no 2761 0.1957774827218 3983 4686136
SGTC_565 1418-0001 44.5 µM -0.856871578156955 0.178605109302392 no 2762 0.1957579309455 3993 2862145
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.857665126118607 0.178386630500215 no 2763 0.195538701050657 3932 165521
SGTC_2111 5486399 200 µM -0.857760788355657 0.178360304249608 no 2764 0.19551228295197 3869 689674
SGTC_2348 9022543 33.42 µM -0.85855330302798 0.178142298342344 no 2765 0.195293505344705 3960 3162678 YDL140C RPO21
SGTC_126 0417-1624 672.48 µM -0.860109705767028 0.177714650258075 no 2766 0.194864285766994 3973 41912 YDL195W SEC31
SGTC_954 1189-0853 2.85 µM -0.863066644547227 0.176903967051209 no 2767 0.194050412959674 3874 2828194
SGTC_3095 9117207 49.47 µM -0.863806385646302 0.176701523463744 no 2768 0.193847129692319 3898 17015229
SGTC_2086 5274770 176.623 µM -0.864584824454509 0.176488647780098 no 2769 0.19363335239113 3988 689278
SGTC_2191 5911152 200 µM -0.864981952826934 0.176380109626951 no 2770 0.193524347157596 3926 2875902
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.86565179279936 0.176197133065718 no 2771 0.193340571887376 4002 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3155 9099265 49.47 µM -0.866050929723938 0.176088160134377 no 2772 0.193231116537477 3959 25236499
SGTC_2923 7992654 58.14 µM -0.867623752968683 0.175659161133108 no 2773 0.192800169378549 3944 2985126
SGTC_292 k038-0015 474 µM -0.869003447214255 0.175283385204334 no 2774 0.192422622634751 3916 46368540
SGTC_610 4215-0184 155 µM -0.869062657161047 0.175267270095531 no 2775 0.192406430238064 3940 5605015
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.872113281833465 0.174438256209051 no 2776 0.191573290545828 3879 6708514
SGTC_748 act1.228 77.9 µM -0.874395288623873 0.173819747185278 no 2777 0.190951511126834 3885 4421505 YNR035C ARC35
SGTC_3244 9134489 49.47 µM -0.874441182825181 0.173807322468732 no 2778 0.190939019024677 3954 16584271
SGTC_658 3253-0951 102 µM -0.874493311919608 0.173793210494763 no 2779 0.190924830433398 3936 1184878
SGTC_2777 climbazole 1.536 µM -0.874664429619523 0.173746891994397 no 2780 0.190878259854425 3846 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2108 5365811 200 µM -0.8748902616095 0.173685775335939 no 2781 0.190816809163495 3978 780283
SGTC_727 3032-0951 202 µM -0.876945308332524 0.173130248991083 no 2782 0.190258172488946 3944 3652836
SGTC_3204 9114183 49.47 µM -0.878984295570418 0.172580183665101 no 2783 0.18970489545484 3954 17027248
SGTC_518 1021-0119 62.6 µM -0.879527019408441 0.172433958984984 no 2784 0.189557794839114 3923 1097762
SGTC_3098 9119039 49.47 µM -0.879582226685097 0.172419089060572 no 2785 0.189542835316407 3928 17161528
SGTC_2329 6138490 200 µM -0.880614328811105 0.172141245851632 no 2786 0.189263300215878 4080 720019
SGTC_1868 st057644 42.7 µM -0.881868833813243 0.171803916474033 no 2787 0.188923871335042 3953 688665
SGTC_2910 7948405 25.97 µM -0.883840429032553 0.17127461929514 no 2788 0.188391179263111 3844 2971328
SGTC_2525 harmine 47.85 µM -0.886255330042363 0.170627733769203 no 2789 0.187739977113863 3948 5280953 A monoamine oxidase inhibitor
SGTC_1473 k844-0725 134 µM -0.887552787246389 0.170280827468056 no 2790 0.187390679724353 4013 54682906
SGTC_1719 st032227 49.2 µM -0.888460377693414 0.170038430170982 no 2791 0.187146580001602 3960 3125804
SGTC_3166 9102297 49.47 µM -0.888607636556938 0.169999121455246 no 2792 0.187106992749883 3984 25237072
SGTC_608 k048-0125 159 µM -0.889471300514907 0.169768695589318 no 2793 0.186874920295199 3994 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2220 6782180 200 µM -0.890191072752833 0.169576813184345 no 2794 0.186681648682798 3865 833803
SGTC_2789 5281112 71.43 µM -0.890269896108108 0.169555808305781 no 2795 0.186660490734335 3989 765948
SGTC_2461 5755302 26.15 µM -0.890586469688542 0.169471464469902 no 2796 0.186575530272986 4005 2788904
SGTC_2420 aureobasidin a 50 nM -0.890795949121465 0.169415668240023 no 2797 0.186519324379736 4103 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_919 tnp00227 403.569 nM -0.893281921559769 0.168754413364133 no 2798 0.185853108428986 3942 1269246 A methoxyflavone. YNL221C POP1
SGTC_2194 5927483 104.545 µM -0.894240177676434 0.168499966038028 no 2799 0.185596699861353 3966 760979
SGTC_3232 9132874 49.47 µM -0.894680347609107 0.168383169710991 no 2800 0.18547899353679 3925 3784940
SGTC_822 1487-0950 154 µM -0.89639311253852 0.167929193882918 no 2801 0.185021422251868 3982 1958375
SGTC_417 st075190 100 µM -0.899589089126636 0.167084195094434 no 2802 0.184169482886152 3979 222757
SGTC_992 3909-8734 162 µM -0.900872799484382 0.166745562180533 no 2803 0.183827977497598 3988 4288319
SGTC_3033 9090887 49.47 µM -0.901272107627419 0.166640318124724 no 2804 0.183721830055649 3998 19325384
SGTC_1617 st002906 78 µM -0.902913733663733 0.166208091812852 no 2805 0.18328584056357 3967 5150859
SGTC_2475 5812728 15.03 µM -0.903124283213222 0.166152708330218 no 2806 0.183229968705688 3938 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_217 ketoconazole 989 nM -0.903133588482684 0.166150260923869 no 2807 0.183227499685522 3855 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2835 9006588 71.43 µM -0.90345031727046 0.166066971038762 no 2808 0.183143472604621 4057 2345538
SGTC_702 1488-0190 94 µM -0.905048479280952 0.165647115373974 no 2809 0.182719852334454 4008 949357
SGTC_859 0439-0102 54.6 µM -0.905451235902994 0.165541414930374 no 2810 0.182613191366824 3959 610143
SGTC_2557 derrustone 83.84 µM -0.906491363240432 0.165268643195437 no 2811 0.18233791711354 3969 629853 An antioxidant.
SGTC_2187 6125751 200 µM -0.907685862417259 0.164955746725062 no 2812 0.182022107716358 3978 874498
SGTC_386 1509-0011 3.07 µM -0.908750828642473 0.164677104807876 no 2813 0.181740833643802 4005 3107280
SGTC_1865 st057639 52.2 µM -0.909775804314253 0.164409214341937 no 2814 0.181470378643679 3960 688818
SGTC_3303 9125618 40.5795 µM -0.911072369736689 0.164070745371793 no 2815 0.181128621796786 4015 22695467
SGTC_1766 st045414 44.774 µM -0.913495324870366 0.16343944438886 no 2816 0.180491045647005 4020 253960
SGTC_1115 galangin 695.678 nM -0.913793814818734 0.163361782127379 no 2817 0.180412598546035 4019 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1530 rhein 70.4 µM -0.913803727403176 0.163359203444419 no 2818 0.180409993754947 4042 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2193 5925765 200 µM -0.913842292427922 0.163349171300008 no 2819 0.180399860009469 3975 877370
SGTC_2360 9040895 200 µM -0.915461600808731 0.162928292418556 no 2820 0.179974676114725 4032 4914414
SGTC_1372 2752-0194 270 µM -0.915607969756698 0.16289028403994 no 2821 0.179936274866301 3948 823334
SGTC_3030 9087619 49.47 µM -0.917476997543811 0.162405450859284 no 2822 0.179446370571125 4017 25236973
SGTC_1116 jasmonic acid 1.58368 µM -0.918405450407103 0.162164956050814 no 2823 0.17920331915042 4059 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3194 9111903 49.47 µM -0.921315183780105 0.161412758136019 no 2824 0.178442948020744 4032 17087251
SGTC_1382 3002-2117 298 µM -0.921362093934056 0.161400650014337 no 2825 0.178430706136862 4074 1497314
SGTC_3137 9097352 49.47 µM -0.921560012495678 0.161349571177554 no 2826 0.178379062247943 4006 44120435
SGTC_2772 vinpocetine 57.06 µM -0.921998797107246 0.161236367213876 no 2827 0.178264601552999 4000 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2255 7941087 197.44 µM -0.922959675559754 0.160988646984941 no 2828 0.178014109946975 4081 935561
SGTC_1231 0242-0792 125 µM -0.924411975556009 0.160614707036837 no 2829 0.177635931001336 3991 3707635
SGTC_935 2996-0153 430 µM -0.924754241268413 0.160526662720886 no 2830 0.177546878876005 4022 23738523
SGTC_977 1348-1378 135 µM -0.926171946273096 0.160162308603102 no 2831 0.177178314595362 3994 X977
SGTC_2691 st077356 60.2 µM -0.926762400883166 0.160010719728925 no 2832 0.177024955297767 4074 2839272
SGTC_41 0478-0632 82.643 µM -0.927155906156911 0.159909746262078 no 2833 0.176922796412538 3903 3750424
SGTC_547 1120-0019 610 nM -0.928868359374497 0.159470816129987 no 2834 0.176478656139802 3941 3676939
SGTC_2508 celastrol 40.54 µM -0.929222354840979 0.159380179690752 no 2835 0.176386932243746 3945 122724 Celastrol is a natural product and antioxidant.
SGTC_454 lyso-paf C-16 6.67 µM -0.930470893753722 0.159060775082036 no 2836 0.176063663706502 3981 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_754 3474-0146 171 µM -0.930643005658913 0.159016777860216 no 2837 0.176019130361914 3969 24762078
SGTC_2918 7977171 22.06 µM -0.931046088178425 0.158913768485615 no 2838 0.17591486210364 3959 2236483
SGTC_2342 7990637 118.86 µM -0.933014908272514 0.158411257101006 no 2839 0.175406135511042 4083 2033102 YER133W GLC7
SGTC_535 2293-4129 48.2 µM -0.933460454157673 0.158297683086294 no 2840 0.175291139732483 4029 396118 YIL048W NEO1
SGTC_492 tmb-8 126 µM -0.93541633156045 0.1577997429812 no 2841 0.174786891807047 3940 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3289 9119912 71.43 µM -0.935557925852139 0.157763734953184 no 2842 0.17475042292865 4065 17014829
SGTC_2089 5281248 129.67 µM -0.936392887189044 0.157551510502616 no 2843 0.174535469390519 4002 2737878
SGTC_2176 5809774 33.9695 µM -0.937288649678664 0.157324040729699 no 2844 0.174305049916179 3988 2870539
SGTC_1661 st013063 9.66 µM -0.938821294090129 0.156935342238607 no 2845 0.173911252034945 4057 721395
SGTC_2315 7733312 200 µM -0.940802611368366 0.156433791598992 no 2846 0.173403011215655 3947 726316
SGTC_2884 9058502 51.95 µM -0.940993872308716 0.156385431734329 no 2847 0.173353999694731 4067 6471554
SGTC_3106 9121286 49.47 µM -0.942893131707282 0.155905742991689 no 2848 0.172867784181582 4049 15943471
SGTC_576 1073-0113 22.7 µM -0.943467610815454 0.155760840248025 no 2849 0.172720887338852 4173 5439563
SGTC_1334 1486-0610 236 µM -0.943915534338172 0.155647920668097 no 2850 0.172606406543422 4113 3742339
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.944187695103977 0.155579336493533 no 2851 0.172536871024664 4030 6728940
SGTC_2257 7960413 200 µM -0.944246803411357 0.155564443908816 no 2852 0.172521771551715 4015 2974689 YIL048W NEO1
SGTC_17 0960-0276 49.807 µM -0.947447602038813 0.154759393573757 no 2853 0.171705372242261 4022 6821114
SGTC_1156 4092-0367 4.88 µM -0.949126619358898 0.154338197349653 no 2854 0.171278108619799 4036 1357585
SGTC_3 0833-0587 95.581 µM -0.950614401098144 0.153965608238013 no 2855 0.17090007770075 3946 5382644
SGTC_1171 0368-0077 21.4 µM -0.951173315879533 0.153825791654581 no 2856 0.170758200923688 3978 3239779
SGTC_2803 7707263 71.43 µM -0.951201325960467 0.153818786941831 no 2857 0.170751092736208 4010 2199229
SGTC_377 3970-0964 33.1 µM -0.952458305497823 0.153504660989139 no 2858 0.170432300883313 3991 16481235
SGTC_967 1306-0166 352 µM -0.953404485350233 0.153268486018676 no 2859 0.170192584854148 4009 4437607
SGTC_235 0330-0087 5 mM -0.953482192421971 0.153249100341561 no 2860 0.170172907260048 4054 46494818 YHR062C RPP1
SGTC_1202 1988-0068 29.6 µM -0.954791567897006 0.152922693201687 no 2861 0.169841556194847 4000 2850480
SGTC_2369 9071472 200 µM -0.955021436572326 0.15286543808138 no 2862 0.169783428256108 4102 17296037
SGTC_2295 7971645 200 µM -0.955080461681037 0.152850738547451 no 2863 0.169768504366867 4085 2978226 YKL099C UTP11
SGTC_61 0978-8327 98.565 µM -0.955156198929308 0.152831878417741 no 2864 0.169749356218022 3964 6150059 YHR072W ERG7
SGTC_739 1486-1183 203 µM -0.955378253012892 0.152776591287747 no 2865 0.169693223732918 4044 4346692
SGTC_2520 obtusaquinone 4.71 µM -0.956840948082005 0.152412740280237 no 2866 0.169323770329315 4090 5967872
SGTC_120 rhodamine 6G 52.259 µM -0.959182790377308 0.151831396477344 no 2867 0.168733334308972 4058 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_862 0452-0056 10.2 µM -0.960350934954552 0.151541965306431 no 2868 0.168439311547419 4007 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.961377360724408 0.151287950743048 no 2869 0.168181231595482 4018 803109
SGTC_1908 st060353 56.5 µM -0.962586271312864 0.150989139176997 no 2870 0.167877594917634 4105 4227716
SGTC_2313 7726885 200 µM -0.964704726471841 0.150466459436747 no 2871 0.167346363610463 4100 726423
SGTC_2451 5856223 45.7 µM -0.965392896609609 0.150296929080509 no 2872 0.167174029006011 4026 2179896
SGTC_1802 st050112 57.9 µM -0.965551785541883 0.150257804968885 no 2873 0.167134255601323 4043 4662563
SGTC_1417 3966-0327 90.4 µM -0.968168372165851 0.149614484464175 no 2874 0.166480143873685 4144 651118
SGTC_2439 5492030 7.2 µM -0.96992227517019 0.149184295851526 no 2875 0.166042617970628 4039 5722370
SGTC_166 k072-0058 166.424 µM -0.970853404695733 0.148956249034753 no 2876 0.165810642049619 3978 5846229
SGTC_2982 9019404 25.97 µM -0.971665250940817 0.148757606539957 no 2877 0.165608554686784 3994 22333232
SGTC_1343 1487-0095 224 µM -0.975539831450195 0.147812014117997 no 2878 0.164646276907943 4079 4560101 YGL055W OLE1
SGTC_623 k072-0108 16.9 µM -0.978733329301451 0.147035672162052 no 2879 0.163855879711526 4028 5382803
SGTC_2213 7173844 200 µM -0.97900888488486 0.146968812750074 no 2880 0.163787794739928 4020 892728
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.979599684128655 0.146825532941677 no 2881 0.163641880464296 4018 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3231 9132313 49.47 µM -0.982652335891326 0.14608670136936 no 2882 0.162889288462429 4036 4905967
SGTC_332 4112-0506 40.9 µM -0.984685009565629 0.145596122061539 no 2883 0.162389409137702 4020 2790355
SGTC_3281 9140613 49.47 µM -0.986903320483933 0.145062005277446 no 2884 0.161845018142003 4080 16013766
SGTC_1037 k284-1091 78.7 µM -0.988170179003506 0.144757568103092 no 2885 0.161534655149043 4051 3334711
SGTC_971 1315-0384 26.7 µM -0.991457643003167 0.14396957002052 no 2886 0.160731082662814 4112 6769120
SGTC_1186 1319-0216 26 µM -0.991914004372888 0.143860410299257 no 2887 0.160619738490762 4142 4565136
SGTC_1403 3909-7815 62.9 µM -0.999222626228026 0.142119825597695 no 2888 0.158843428738938 4032 6615483
SGTC_1750 st081859 2.357 µM -0.999970040271388 0.14194263198471 no 2889 0.15866250341729 4055 5291695
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.00018043077444 0.141892780525218 no 2890 0.158611598904952 4190 688801
SGTC_3072 9116419 49.47 µM -1.00167599613524 0.141538752043351 no 2891 0.158250051775574 4132 17170162
SGTC_2634 4'-methoxyflavone 100 µM -1.00177103124703 0.141516275684719 no 2892 0.15822709569411 4097 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2391 6285546 200 µM -1.00189457940216 0.141487059440845 no 2893 0.158197255449221 4076 846083
SGTC_2935 9038016 29.96 µM -1.00264705271925 0.141309205389834 no 2894 0.158015592397044 4088 6463195
SGTC_2104 5389443 200 µM -1.00319679375607 0.141179364836402 no 2895 0.157882959836797 4139 2244536
SGTC_2506 ethyl hematommate 54.16 µM -1.00479533791057 0.140802272474555 no 2896 0.157497704622818 4171 3940691 An allergen.
SGTC_1770 st043884 66.3 µM -1.00589336097719 0.140543647999617 no 2897 0.157233435109402 4088 670149
SGTC_3247 9135149 49.47 µM -1.00681568038774 0.140326657489087 no 2898 0.157011678959913 4088 8934436 YOR116C RPO31
SGTC_348 k064-0012 10.7 µM -1.00845166298648 0.139942326148596 no 2899 0.156618840870409 3998 5066323
SGTC_1167 k781-0610 148 µM -1.00881441968335 0.139857202933794 no 2900 0.156531822129012 4130 4525169
SGTC_959 1222-0044 107 µM -1.01049245634283 0.139463898723941 no 2901 0.156129705901279 4101 6083612
SGTC_125 0133-0007 11.75 µM -1.01060313716771 0.13943798343184 no 2902 0.156103206857466 4176 26541
SGTC_50 0929-0078 56.389 µM -1.01338671921362 0.138787300411438 no 2903 0.155437740229853 3964 1377751
SGTC_3224 9130643 49.47 µM -1.01357537111738 0.138743276572902 no 2904 0.15539270734082 4166 17644395
SGTC_2759 disulfiram 3.38 µM -1.01368212289386 0.138718369175555 no 2905 0.155367228555902 4006 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3002 9075603 71.4286 µM -1.0165291596664 0.138055220264269 no 2906 0.154688734479346 4045 20105405
SGTC_3090 9117696 49.47 µM -1.02084111729512 0.137054976029239 no 2907 0.153664860146218 4076 7923821
SGTC_2137 5261020 140 µM -1.02140500234966 0.136924538721786 no 2908 0.153531298152506 4076 763655
SGTC_3269 9137823 49.47 µM -1.02187765720826 0.136815270069645 no 2909 0.15341940421902 4018 17682936
SGTC_1960 st011366 51.8 µM -1.02198607052325 0.136790215416397 no 2910 0.153393746614167 4123 3972846
SGTC_302 1094-0063 18.9 µM -1.02351407649493 0.136437422116422 no 2911 0.153032423904096 4088 5440289
SGTC_142 0335-0849 62.6745 µM -1.02451051353322 0.136207695545763 no 2912 0.152797103776213 4115 3889043 YPR107C YTH1
SGTC_1176 0848-0131 83.3 µM -1.02646282733643 0.13575836123918 no 2913 0.152336738371016 4153 6769040
SGTC_606 k015-0008 38.6 µM -1.02744660309936 0.135532325675781 no 2914 0.152105108326466 4211 1970475
SGTC_1615 st002656 86.5 µM -1.02906402883485 0.135161261371137 no 2915 0.151724793999202 4118 1584458
SGTC_577 r071-0003 38.6 µM -1.0295895118068 0.135040856913045 no 2916 0.15160137038531 4127 4568517 YMR134W ERG29
SGTC_2358 9037157 4 µM -1.02991733377022 0.134965779996765 no 2917 0.151524406516325 4125 2388925
SGTC_1041 0206-0046 107 µM -1.03077592425911 0.134769283583508 no 2918 0.151322955459242 4128 50494
SGTC_766 1391-0721 126 µM -1.03088283740827 0.134744829265953 no 2919 0.15129788290791 4157 1020919 YIL115C NUP159
SGTC_39 0986-0283 58.349 µM -1.03151708235672 0.134599820596523 no 2920 0.151149200874303 4208 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3301 9125354 19.7965 µM -1.03269211713714 0.13433145320857 no 2921 0.150874001854405 4092 41905162
SGTC_2151 5563267 85.4165 µM -1.03314707018774 0.134227644760795 no 2922 0.150767539200935 4171 5310824
SGTC_221 trifluoperazine 10.304 µM -1.03353693041762 0.134138732649746 no 2923 0.150676348592654 4091 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_148 3253-0744 288.01 µM -1.03490612403232 0.13382679289225 no 2924 0.150356377187898 4005 6893655
SGTC_344 k064-0035 6.43 µM -1.0354692126828 0.133698650703775 no 2925 0.150224918611972 4080 5088750
SGTC_2778 tioconazole 65.09 nM -1.03626579682039 0.133517516024842 no 2926 0.150039079096184 4024 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3283 9109332 35.8195 µM -1.03758194840553 0.13321860722347 no 2927 0.149732362799603 3966 17027281
SGTC_234 nsc-17383 10.7 µM -1.03760036578909 0.133214427754327 no 2928 0.149728073777584 4145 408974
SGTC_813 k007-0158 173 µM -1.04047325372619 0.132563585922076 no 2929 0.149060041961789 4124 6523916
SGTC_2807 7945238 51.95 µM -1.04077039417715 0.132496395108453 no 2930 0.148991061762076 4167 17148797
SGTC_262 fenpropimorph 62.5 µM -1.0417647679209 0.132271713260775 no 2931 0.148760376214253 4097 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2861 9024595 19.48 µM -1.04188344235907 0.132244915954527 no 2932 0.148732860791796 4029 16482810
SGTC_856 0433-0016 11.3 µM -1.04445050945804 0.131666174757066 no 2933 0.148138502607918 4183 3911780
SGTC_2825 7998094 58.44 µM -1.04605011754719 0.131306430802746 no 2934 0.147768946971339 4145 2987815
SGTC_1952 st077036 64.1 µM -1.04922747561481 0.130593873218831 no 2935 0.147036717963038 4161 2937007
SGTC_1980 st071811 45.7 µM -1.04967462659257 0.130493809700949 no 2936 0.146933866688445 4237 4974850
SGTC_2667 digitoxin 100 µM -1.05168177063628 0.130045303933296 no 2937 0.146472788671608 4074 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_746 1095-0025 46.6 µM -1.05199442573412 0.129975535841645 no 2938 0.146401053552498 4147 6749286
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.05626166489128 0.129025903235962 no 2939 0.145424342446926 4124 6708739 YPR165W RHO1
SGTC_2063 5246145 200 µM -1.0570262219321 0.128856268024284 no 2940 0.145249810135096 4184 711240
SGTC_2711 st079103 59.1 µM -1.05803359358687 0.128632994889478 no 2941 0.145020063614963 4101 54693780
SGTC_2773 thioridazine 9.09 µM -1.05890676864165 0.128439682309925 no 2942 0.144821120691834 4164 5452 An antipsychotic.
SGTC_584 0986-0246 15.4 µM -1.06114579152116 0.127944906007556 no 2943 0.144311825154975 4236 53315 YDR232W HEM1
SGTC_3180 9109287 49.47 µM -1.0614715509968 0.127873030611592 no 2944 0.144237827550274 4202 18891271
SGTC_3164 9100705 49.47 µM -1.06155483371653 0.127854659661372 no 2945 0.14421891364426 4187 17174235
SGTC_55 0767-0285 6.563 µM -1.06264863480215 0.127613553351014 no 2946 0.143970661343781 4070 3116166
SGTC_3157 9099274 49.47 µM -1.06286366776291 0.12756619089108 no 2947 0.143921890753612 4198 17217662
SGTC_2848 9016370 25.97 µM -1.0629492919217 0.127547334995206 no 2948 0.143902473853114 4152 7894410
SGTC_653 0203-0016 55.2 µM -1.06422096711272 0.127267518596536 no 2949 0.143614305413169 4205 295302
SGTC_2515 chrysin 20.77 µM -1.06491851503831 0.127114213298937 no 2950 0.143456402823067 4178 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2595 hexamethylquercetagetin 100 µM -1.06503966201757 0.12708760102833 no 2951 0.143428990963507 4147 386331
SGTC_1097 itavastatin 7.23 µM -1.068536240835 0.126321180452494 no 2952 0.142639345898929 4176 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_694 1315-0438 43.2 µM -1.06860166581535 0.126306870611889 no 2953 0.142624598808403 4151 6793154
SGTC_2802 7925815 54.55 µM -1.07077371098607 0.125832439124171 no 2954 0.142135595088086 4131 1262923
SGTC_500 h-89 112 µM -1.07531808009973 0.12484385426285 no 2955 0.141116172110225 4186 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1336 1486-0901 104 µM -1.0760598824823 0.124682998752304 no 2956 0.140950237971479 4190 5006114
SGTC_2886 9058944 51.95 µM -1.08036010045564 0.123753375511978 no 2957 0.139990928053009 4039 4949929
SGTC_2083 5306046 65.942 µM -1.08063542083869 0.123694022341441 no 2958 0.139929659959457 4184 539837
SGTC_60 0986-0278 202 µM -1.08521885452586 0.122708859283215 no 2959 0.138912367693962 4126 3110598
SGTC_1492 4158-0558 28.5 µM -1.0867384821857 0.122383448709947 no 2960 0.138576200958562 4180 3967268
SGTC_1232 0279-0259 161 µM -1.08719259114806 0.122286324203279 no 2961 0.138475852210057 4182 1560000
SGTC_652 0437-0092 114 µM -1.08931367620865 0.121833384636064 no 2962 0.138007791917615 4112 3091274
SGTC_794 k038-0031 316 µM -1.09074605852122 0.121528179137254 no 2963 0.137692318880681 4173 6624242
SGTC_711 k292-0785 179 µM -1.09308529561693 0.121030901414172 no 2964 0.137178175737462 4119 4146315
SGTC_1483 3453-0561 55.9 µM -1.09460354393645 0.120708917527183 no 2965 0.136845181159897 4189 4546991
SGTC_2908 7930301 100 µM -1.09462912422816 0.120703497733997 no 2966 0.136839575419143 4168 2223178
SGTC_3349 9149703 23.001 µM -1.09696172903847 0.120209999782916 no 2967 0.136329061159324 4197 4910494
SGTC_3097 9117246 49.47 µM -1.09773963657159 0.120045738180433 no 2968 0.136159098310557 4201 16423892
SGTC_91 0417-1751 58.384 µM -1.09967927122954 0.119636857457856 no 2969 0.135735944732899 4295 6795624
SGTC_2055 5235184 200 µM -1.10075077481265 0.119411402991112 no 2970 0.135502570553097 4242 2836034
SGTC_1013 4112-3890 241 µM -1.10174489053155 0.119202499900774 no 2971 0.135286297509882 4133 705171
SGTC_1668 st014914 51.6 µM -1.10366049191031 0.118800683936256 no 2972 0.134870219912339 4200 2839556
SGTC_2467 5474540 200 µM -1.104009689502 0.118727539576765 no 2973 0.134794467261264 4155 5413519
SGTC_1613 st002381 52.1 µM -1.10609361229461 0.118291694005886 no 2974 0.134343001613295 4173 551167
SGTC_86 0417-1630 471.922 µM -1.10822956397254 0.117846141940146 no 2975 0.133881342995357 4204 3634867
SGTC_1407 3909-7909 12.3 µM -1.10887386696723 0.117711976001669 no 2976 0.133742299455297 4199 4411780
SGTC_1597 7-benzyloxygramine 47.5 µM -1.11012931741294 0.117450858874702 no 2977 0.133471652750376 4125 260807
SGTC_1461 k072-0203 53.8 µM -1.11046431579386 0.117381253005126 no 2978 0.133399498394481 4110 5418714
SGTC_1444 4112-3581 28 µM -1.11087381275417 0.117296207527623 no 2979 0.133311334452039 4243 2877249
SGTC_1190 1486-1332 13 µM -1.11501363865931 0.116438887023925 no 2980 0.132422288625186 4189 4150046
SGTC_318 1488-0629 67.2 µM -1.11694036697181 0.116041398441295 no 2981 0.132009911683559 4253 3662576
SGTC_161 4065-0411 162.148 µM -1.11704229279865 0.116020397761561 no 2982 0.131988121228942 4200 1906281 YLR208W SEC13
SGTC_528 3492-0019 172 µM -1.11746992287022 0.115932318760627 no 2983 0.131896726357429 4202 2869262
SGTC_380 3970-0968 6 µM -1.11949256311968 0.115516358723197 no 2984 0.13146503091068 4097 2891601
SGTC_1406 3909-7906 11.9 µM -1.11990879313606 0.115430891909061 no 2985 0.131376315403993 4223 X1406
SGTC_458 nppb 133 µM -1.12058227615689 0.115292697106588 no 2986 0.131232856411487 4258 4549 A chloride channel blocker.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.12675742779587 0.114031072408204 no 2987 0.129922527274726 4275 1273210
SGTC_946 3434-1334 87.4 µM -1.12700522970953 0.11398065089086 no 2988 0.129870134934868 4204 4047976
SGTC_1662 st014054 52 µM -1.12855049952346 0.113666585330539 no 2989 0.129543751180786 4258 2838777
SGTC_3277 9138724 49.47 µM -1.12941836248888 0.113490468862474 no 2990 0.129360695132462 4182 15943418
SGTC_1948 st076329 66.6 µM -1.12953415899508 0.113466984860799 no 2991 0.129336284042177 4113 24208413
SGTC_737 1950-0117 57.9 µM -1.13349266945558 0.112666265978165 no 2992 0.128503708937442 4210 5393513
SGTC_1438 4092-1045 4 µM -1.13364869731252 0.112634787873727 no 2993 0.128470968701404 4239 1351342
SGTC_2837 9008476 45.46 µM -1.13391070374354 0.112581943072335 no 2994 0.128416003388473 4238 2992805
SGTC_2118 5526350 200 µM -1.13544828976849 0.112272179973227 no 2995 0.128093768204409 4266 743594
SGTC_24 0417-1663 219 µM -1.13629599226243 0.112101661961607 no 2996 0.127916353765792 4252 4329390
SGTC_728 3030-5151 22.5 µM -1.13882028024466 0.111594990204025 no 2997 0.127389060643661 4305 3125388
SGTC_2311 7694451 200 µM -1.14031199109878 0.111296347292754 no 2998 0.127078171943703 4208 2163142
SGTC_466 geldanamycin 89.2 µM -1.14051404557365 0.111255939699807 no 2999 0.127036102238945 4200 5288382 HSP90 inhibitor.
SGTC_645 0845-0943 5.41 µM -1.14726177243284 0.109912531776733 no 3000 0.125636724081896 4246 1885106
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.14775770663132 0.10981425723524 no 3001 0.125534300659329 4323 688664
SGTC_797 k781-0471 270 µM -1.1510821142136 0.109157119232773 no 3002 0.124849227718248 4213 23738129
SGTC_957 1187-1561 14.1 µM -1.15406978362782 0.108568959583773 no 3003 0.12423578012848 4196 1538454
SGTC_2682 pyrogallin 40.03 µM -1.15582797677894 0.108223904841634 no 3004 0.123875763581626 4250 822798 An ATP competetive kinase inhibitor.
SGTC_1612 st002233 45.4 µM -1.15754594273441 0.107887508038737 no 3005 0.123524690141436 4246 1035021
SGTC_1764 st044502 93.5 µM -1.15934060276964 0.10753689861425 no 3006 0.123158688802324 4291 8407
SGTC_2713 st079149 53.4 µM -1.16019989706064 0.107369315659107 no 3007 0.122983714447096 4260 3103253
SGTC_3140 9094243 49.47 µM -1.16110929774985 0.107192165886763 no 3008 0.122798727044111 4226 19291112
SGTC_2312 7706453 155.7 µM -1.16258285850804 0.106905566252183 no 3009 0.122499394429345 4246 976098
SGTC_2737 bleomycin 30.5 nM -1.16482214053307 0.106471096990337 no 3010 0.122045497403936 4332 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2717 st081029 62.2815 µM -1.16659899318305 0.106127257262206 no 3011 0.121686175068761 4226 5292846
SGTC_2325 6158266 200 µM -1.16751076214659 0.105951132101698 no 3012 0.121502082345007 4256 3623240
SGTC_371 0195-0006 7.36 µM -1.169265442727 0.105612777454448 no 3013 0.121148350810418 4078 3928593
SGTC_1614 st002383 48.6 µM -1.17102659624168 0.105273960974633 no 3014 0.120794043395337 4280 1947235
SGTC_1838 st055369 84.5 µM -1.17212209863759 0.105063601772478 no 3015 0.120574019400969 4253 676036
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.17225578444787 0.105037952164845 no 3016 0.120547188872608 4220 2333 A French combination drug.
SGTC_450 aminopyrene 156 nM -1.17258254664606 0.104975277064859 no 3017 0.120481625919169 4218 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2026 5148700 152 µM -1.17288379506425 0.104917519660503 no 3018 0.120421204409783 4236 79838
SGTC_2117 5521686 200 µM -1.17540190442757 0.104435630248314 no 3019 0.119916980972743 4224 803312
SGTC_1132 3456-3614 2.5 µM -1.17942233759226 0.103669569599688 no 3020 0.119115022358109 4312 3125502
SGTC_575 k072-0246 11.9 µM -1.18045862071631 0.103472776864588 no 3021 0.118908929385891 4345 6796779
SGTC_670 4204-0025 119 µM -1.1811758217251 0.103336737466724 no 3022 0.118766442072263 4283 719039
SGTC_2466 5983409 37.09 µM -1.181341571478 0.103305316369403 no 3023 0.118733529505563 4275 2879657
SGTC_1515 3460-0031 42.1 µM -1.18223240072708 0.103136561134452 no 3024 0.118556749861337 4211 2876596
SGTC_558 k064-0027 21.3 µM -1.18242492896815 0.103100115656404 no 3025 0.118518568259153 4263 5088526
SGTC_767 0929-0023 86 µM -1.18272555577257 0.103043225893668 no 3026 0.118458966266371 4278 1204563
SGTC_1667 st014849 34.6 µM -1.18591776315702 0.102440547673263 no 3027 0.117827388760185 4347 5348460
SGTC_2019 4016004 108 µM -1.18619987952244 0.102387408558754 no 3028 0.117771686911665 4307 45595336
SGTC_424 splitomicin 100 mM -1.18829688561692 0.10199304704947 no 3029 0.117358232144602 4323 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_934 2950-0684 338 µM -1.18869579565486 0.101918153603831 no 3030 0.117279697833272 4308 1121253
SGTC_2971 9092186 9.93 µM -1.18893032932264 0.101874139720648 no 3031 0.117233542045319 4265 25236400
SGTC_2707 st078556 66.6 µM -1.19010739115254 0.101653454735728 no 3032 0.117002092808754 4213 17250899
SGTC_2401 5128683 200 µM -1.19075893886843 0.101531447117347 no 3033 0.116874116322243 4291 708373
SGTC_2423 st077119 87.2 µM -1.1940280447314 0.100920890174029 no 3034 0.116233498969496 4204 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2424 5537928 59.2 µM -1.19468885669993 0.100797799051187 no 3035 0.116104308896452 4281 5382802
SGTC_3183 9108214 49.47 µM -1.19550773283326 0.100645416852132 no 3036 0.11594435840439 4219 4974831
SGTC_2289 7946404 165.07 µM -1.19633761359022 0.100491158339248 no 3037 0.115782418066438 4274 1246120 YPR165W RHO1
SGTC_1340 1486-1359 257 µM -1.19709364308146 0.100350777547179 no 3038 0.115635028717947 4207 4309068
SGTC_255 tunicamycin 200.472 nM -1.19849661142866 0.100090651398168 no 3039 0.115361870702729 4206 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2175 5807670 165.306 µM -1.2012115413945 0.0995886715671045 no 3040 0.114834576772072 4250 241186
SGTC_506 n9-isopropylolomoucine 153 µM -1.20317262559675 0.0992272209466265 no 3041 0.114454762870889 4295 6610355
SGTC_1737 st035557 69.7 µM -1.20655327787761 0.0986063812050322 no 3042 0.113802114652499 4145 5716916
SGTC_295 k015-0027 31 µM -1.20671354711309 0.0985770193247442 no 3043 0.113771240032289 4347 3887424
SGTC_2249 haloperidol 116.36 µM -1.21185817917783 0.0976379022875778 no 3044 0.112783336592625 4262 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_948 3448-0295 75.3 µM -1.21250189006021 0.0975208606441493 no 3045 0.112660159765532 4283 678569
SGTC_121 0557-0495 61.343 µM -1.21377201012513 0.0972902250876676 no 3046 0.112417398726036 4372 3104427
SGTC_2952 9073731 13.78 µM -1.21454504894933 0.0971500483950674 no 3047 0.112269829073652 4325 16457353
SGTC_2986 9022445 71.43 µM -1.21610129065422 0.0968683015933411 no 3048 0.111973169477254 4297 6459286
SGTC_334 1502-1024 68.5 µM -1.21652979252342 0.0967908297340668 no 3049 0.111891584526141 4305 3296216
SGTC_655 k060-0012 42 µM -1.21656439349886 0.0967845759668604 no 3050 0.111884998501497 4282 5994525
SGTC_2024 5144227 134 µM -1.21686994544386 0.0967293635031639 no 3051 0.111826851115204 4304 3475211
SGTC_2831 7999036 19.48 µM -1.21735915380015 0.0966410129621795 no 3052 0.111733798411106 4314 2988270
SGTC_3287 9117173 37.0625 µM -1.22157412011805 0.0958822485754851 no 3053 0.110934360181959 4306 2789709
SGTC_2363 9053361 176 µM -1.22328846892465 0.0955748938391536 no 3054 0.110610380444443 4359 6469797 YMR079W SEC14
SGTC_2670 beta-carotene 100 µM -1.22468602390425 0.0953248719940895 no 3055 0.110346770991401 4256 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1723 st034307 2.5525 µM -1.23127793926511 0.0941520718611061 no 3056 0.109109464953973 4326 867466
SGTC_3291 9121177 71.43 µM -1.23667690196699 0.0931994728395154 no 3057 0.108103528596015 4295 17015612
SGTC_1705 st027868 56.3335 µM -1.23688847068817 0.0931622889655518 no 3058 0.108064245447744 4248 292948
SGTC_3162 9099653 49.47 µM -1.23773239112379 0.0930140763531348 no 3059 0.107907652280469 4291 25237511
SGTC_2782 7736369 71.43 µM -1.24033691456113 0.0925577588293965 no 3060 0.107425402026447 4330 2950836 YOL077C BRX1
SGTC_2863 9028737 58.44 µM -1.24230428370703 0.0922141714539391 no 3061 0.107062157726909 4297 6460917
SGTC_975 1335-0046 28.5 µM -1.24774827624585 0.0912683379871728 no 3062 0.106061627945197 4332 16486740
SGTC_956 1185-0240 191 µM -1.24829103562109 0.0911744353087547 no 3063 0.105962247931395 4297 1416193
SGTC_1236 0330-0013 258 µM -1.25013430864811 0.0908560658652703 no 3064 0.10562524437431 4333 4617066
SGTC_2619 obliquin 87.91 µM -1.2502760451723 0.0908316193788962 no 3065 0.105599362967018 4280 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1235 benzylparaben 21.5 µM -1.25269838346047 0.0904145725778337 no 3066 0.105157747257306 4355 7180
SGTC_124 0136-0217 7.121 µM -1.25836945826342 0.0894437641961217 no 3067 0.104129086021947 4388 3976905
SGTC_2651 TUB2.036 5 µM -1.25860143404102 0.0894042189043553 no 3068 0.104087164404713 4263 15992207 YFL037W TUB2
SGTC_3096 9117468 49.47 µM -1.25921905490832 0.0892989954701999 no 3069 0.103975610406772 4245 41316311
SGTC_205 1486-1330 71.903 µM -1.25958739529812 0.0892362855704028 no 3070 0.103909122457895 4390 4118834
SGTC_2029 5175081 200 µM -1.25997375936247 0.0891705423597057 no 3071 0.10383941425386 4293 1380876
SGTC_717 1532-0246 73.2 µM -1.26098144795845 0.0889992449676692 no 3072 0.103657765651339 4305 9561992
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.26489828221132 0.0883357468228199 no 3073 0.102953896613052 4337 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2204 7233102 200 µM -1.26695826431282 0.0879882755572444 no 3074 0.102585106770296 4267 2172480
SGTC_403 arphamenine a 50 µM -1.2673976738458 0.0879142894109247 no 3075 0.102506565570585 4332 5487158 An arginine aminopeptidase inhibitor.
SGTC_136 0097-0015 404.482 µM -1.26874564246022 0.0876876129366716 no 3076 0.102265898950698 4340 4861337
SGTC_2664 lyso-paf C-16 73.48 µM -1.26887399353699 0.0876660519795289 no 3077 0.102243004567925 4306 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_920 mycophenolic acid 780.421 nM -1.27261661934043 0.0870390878314156 no 3078 0.10157705913194 4319 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3167 9103034 49.47 µM -1.27279175992117 0.0870098305470228 no 3079 0.101545972979515 4426 5127859
SGTC_3260 9137109 49.47 µM -1.27367640631364 0.0868621623649518 no 3080 0.101389060690511 4282 17478346
SGTC_490 phenamil 164 µM -1.2737799505676 0.0868448906541409 no 3081 0.10137070629971 4331 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2057 5236571 38.335 µM -1.27428408401335 0.0867608352768816 no 3082 0.101281377522496 4312 54684039 YBR257W POP4
SGTC_306 1672-3436 11.6 µM -1.27626783623677 0.0864306697486587 no 3083 0.100930427939516 4368 6797378
SGTC_3193 9111931 49.47 µM -1.28007666566226 0.0857993826491435 no 3084 0.100259087156216 4343 17087244
SGTC_7 0192-1582 4.227 µM -1.28331560545308 0.0852652715203779 no 3085 0.0996907637771945 4400 252616
SGTC_1375 2910-0797 186 µM -1.28500537612298 0.0849876138335779 no 3086 0.0993952026837759 4348 742508
SGTC_16 erodoxin 22.806 µM -1.28569591806883 0.0848743414769588 no 3087 0.099274603193849 4369 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3282 9108498 15.4605 µM -1.28641911916775 0.0847558332901094 no 3088 0.0991484146915405 4313 16459645
SGTC_232 clozapine 119 µM -1.28686114639372 0.084683461108297 no 3089 0.0990713448892947 4361 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_791 1348-1292 225 µM -1.2884507455953 0.0844235823966002 no 3090 0.0987945519244454 4323 5437054
SGTC_3271 9137798 49.47 µM -1.29005671210889 0.0841616359660653 no 3091 0.0985154840603446 4325 6498326
SGTC_2555 cholic acid 100 µM -1.29656718351651 0.0831059718688948 no 3092 0.0973900749490545 4310 6708657 Influences liver metabolism.
SGTC_2201 6605497 169.863 µM -1.29899741301914 0.0827144761739776 no 3093 0.0969724084914307 4306 670741
SGTC_3320 9137005 35.139 µM -1.30080265894439 0.0824245612287808 no 3094 0.096663005806227 4413 4908713
SGTC_1963 st076565 50.3 µM -1.31016133719357 0.0809338494540583 no 3095 0.0950706310153074 4386 4914280
SGTC_1610 st001799 48.1 µM -1.31017083730092 0.0809323466241481 no 3096 0.0950690244525277 4320 621897
SGTC_2504 purpurogallin 52.29 µM -1.31172324366457 0.0806870530287635 no 3097 0.0948067656095925 4274 5281571 An antioxidant.
SGTC_2890 9046729 58.44 µM -1.31239379052275 0.0805812746381154 no 3098 0.094693650463724 4336 903329
SGTC_817 1391-0715 46 µM -1.31479404615379 0.0802034940912993 no 3099 0.0942895644852157 4356 1353946
SGTC_683 panaxydol 45 µM -1.31523401445494 0.0801343921020779 no 3100 0.0942156334128802 4387 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1242 0402-0103 60.1 µM -1.31525547888242 0.0801310220231303 no 3101 0.0942120276833219 4301 432868
SGTC_546 peri-Naphthalide 147 µM -1.31556200639479 0.0800829065530244 no 3102 0.0941605463694733 4318 223824 A penicillin ester.
SGTC_1379 2144-0755 36.5 µM -1.317937385664 0.079710784634129 no 3103 0.0937623046507771 4421 5392327
SGTC_3240 9133527 49.47 µM -1.31818883237479 0.0796714702088588 no 3104 0.0937202215029826 4332 17617455
SGTC_784 4579-0127 173 µM -1.31996143442317 0.0793947348311672 no 3105 0.0934239471806509 4407 1948547
SGTC_1493 4348-0038 111 µM -1.32001545040705 0.0793863133923365 no 3106 0.0934149297745258 4350 800424
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.32110808980561 0.0792161090216354 no 3107 0.0932326630152594 4409 688664
SGTC_619 1652-1634 108 µM -1.32255316124209 0.0789914295661112 no 3108 0.0929920096771533 4364 5400454
SGTC_938 3126-1755 342 µM -1.32460640228906 0.0786730225719631 no 3109 0.0926508656682247 4384 1777771
SGTC_2870 9038528 12.99 µM -1.32803998929467 0.0781427326926269 no 3110 0.0920824482740184 4406 6463316
SGTC_1886 st057356 49.9 µM -1.33369816060573 0.0772747953241329 no 3111 0.0911513989296898 4371 24207747
SGTC_2233 sulbentine 40.3845 µM -1.33458957819017 0.077138726363252 no 3112 0.0910053554260333 4389 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3152 9099253 49.47 µM -1.33860758596404 0.0765276631634353 no 3113 0.090349227623315 4274 25236131
SGTC_3248 9135562 49.47 µM -1.33966263015651 0.0763678228283077 no 3114 0.0901775260349982 4367 17650701
SGTC_609 0986-0026 86.3 µM -1.35051464342621 0.0747384453090069 no 3115 0.0884254798824932 4372 2848610
SGTC_3338 9144300 39.5675 µM -1.35827293828694 0.0735899321694405 no 3116 0.0871885469616656 4406 4901274
SGTC_2183 6420625 130.508 µM -1.35863886062945 0.0735360973114922 no 3117 0.0871305273324485 4421 2897619
SGTC_1284 0929-0043 16 µM -1.36137800414159 0.0731340677849751 no 3118 0.086697131779573 4414 1239883
SGTC_1079 idarubicin 2.36 µM -1.36261832782121 0.0729525771573214 no 3119 0.0865014147917589 4422 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1783 st039459 87.517 µM -1.36262575318188 0.0729514916788879 no 3120 0.0865002441017661 4479 729761
SGTC_900 1112-0045 141 µM -1.36316010437965 0.0728734098503274 no 3121 0.0864160288362184 4282 56211 YIL048W NEO1
SGTC_2040 5100729 123 µM -1.36937940109426 0.0719693176192301 no 3122 0.0854403548930977 4438 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2881 9058953 51.95 µM -1.37022630513201 0.0718468723362204 no 3123 0.0853081346611205 4350 17122249
SGTC_1471 k673-0312 37 µM -1.37040332265019 0.0718212993634561 no 3124 0.0852805177357228 4379 24099884
SGTC_1521 st012942 49.4 µM -1.37167877253336 0.0716372468251837 no 3125 0.0850817297229989 4356 24207259
SGTC_1445 4239-0156 97.7 µM -1.37554502663883 0.0710815415226266 no 3126 0.0844812681909158 4455 4008346
SGTC_672 1441-0018 53.7 µM -1.37688005987162 0.0708904250545685 no 3127 0.0842746665467054 4418 251141
SGTC_3343 9148379 18.9835 µM -1.37763093163537 0.0707831077079715 no 3128 0.0841586329215916 4424 1955036
SGTC_1400 3771-8998 51.5 µM -1.37954775434351 0.0705097144526858 no 3129 0.0838629665868215 4360 670767
SGTC_1248 0469-0687 58.6 µM -1.37984631999454 0.0704672036898081 no 3130 0.0838169836974065 4387 4017482
SGTC_1068 loratadine 26.9 µM -1.382414559221 0.0701023426165695 no 3131 0.0834222241306595 4475 3957 A H1 histamine antagonist.
SGTC_1004 4084-0029 199 µM -1.38387883306432 0.0698949696429491 no 3132 0.0831977795353295 4426 716894 YLR208W SEC13
SGTC_2523 spermine 47.74 µM -1.38475141076171 0.0697716183555261 no 3133 0.0830642464844867 4442 1103 A DNA binding polyamine.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.38633249264781 0.0695485368675036 no 3134 0.0828226997571393 4380 279621
SGTC_598 3937-0236 20.2 µM -1.38724786478669 0.069419634427199 no 3135 0.0826830973140409 4491 1379313
SGTC_2140 5586273 200 µM -1.38868465195575 0.0692176776503153 no 3136 0.0824643316463097 4398 854421
SGTC_2269 7935389 174.42 µM -1.3939940196845 0.0684753109743472 no 3137 0.0816597052806599 4421 97605
SGTC_412 gemfibrozil 100 µM -1.3963373764042 0.0681496182655184 no 3138 0.0813064617537888 4377 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_538 2922-0838 53.3 µM -1.40002286007457 0.0676398101618787 no 3139 0.0807532365075124 4452 777039
SGTC_2010 4012422 159 µM -1.40215439577229 0.0673463053855596 no 3140 0.08043457323882 4388 952393
SGTC_3049 9092223 49.47 µM -1.40345070647117 0.0671682900827142 no 3141 0.0802412407163365 4427 8623917
SGTC_1164 k060-0068 93.7 µM -1.40441753705727 0.0670357575358181 no 3142 0.0800972758508338 4446 5963676
SGTC_2477 5967686 25.23 µM -1.41580360394888 0.0654901388958049 no 3143 0.0784165070625734 4431 776118
SGTC_2412 st077135 33.4 µM -1.41631148681178 0.0654218449146947 no 3144 0.0783421630731621 4470 13258915
SGTC_277 nystatin 15.5 µM -1.41956363188081 0.0649858440786358 no 3145 0.0778673797539535 4456 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_184 1494-0393 24.714 µM -1.4220279553402 0.0646569676959048 no 3146 0.0775090678055914 4432 3090647
SGTC_1519 esterone 74 µM -1.42255040487144 0.0645874105323275 no 3147 0.0774332649010229 4419 698 A steroid.
SGTC_968 1309-0633 340 µM -1.42276578431134 0.0645587525675969 no 3148 0.0774020316035921 4479 3761976
SGTC_1441 4106-0040 13 µM -1.42308666591717 0.0645160750136989 no 3149 0.077355516634533 4478 2904180
SGTC_18 0111-0177 500 nM -1.42608332597359 0.0641185738025067 no 3150 0.0769221455888165 4530 721752
SGTC_1862 st057513 3.81 µM -1.43607963027419 0.0628063416049096 no 3151 0.0754898418038126 4435 5393163
SGTC_97 0535-0701 19.132 µM -1.43615257910333 0.0627968429852424 no 3152 0.0754794646674578 4350 2832013 YGL099W LSG1
SGTC_913 3487-1245 167 µM -1.44021013191933 0.0622702722623875 no 3153 0.0749039787773733 4397 4016153
SGTC_1440 4100-1550 40 µM -1.44269984403829 0.0619488776341727 no 3154 0.0745525216013029 4489 742806
SGTC_1397 3532-0190 20.1 µM -1.44270834916877 0.0619477819376928 no 3155 0.0745513231460019 4415 5322280
SGTC_3348 9149464 3.537 µM -1.44567155927744 0.0615669580570788 no 3156 0.0741346725347407 4401 1951442
SGTC_927 2425-1185 123 µM -1.44723766639001 0.0613664259277451 no 3157 0.0739151852334461 4417 730375
SGTC_1194 1488-0194 225 µM -1.45535163590946 0.0603356319969406 no 3158 0.072785969187332 4436 1391452
SGTC_2476 5806916 10.51 µM -1.46563439410986 0.0590488426894962 no 3159 0.0713739579937128 4394 2870194
SGTC_1338 1486-1223 76 µM -1.47286128191386 0.0581574208837129 no 3160 0.0703942219912511 4487 3444526
SGTC_44 0929-0055 61.211 µM -1.47707111483543 0.0576430408277818 no 3161 0.0698282877264775 4352 1379590
SGTC_2189 6047310 154.431 µM -1.48095082813546 0.0571721708906595 no 3162 0.0693098385395102 4470 711535
SGTC_1315 1237-0019 3.69 µM -1.48304602407204 0.0569191447091224 no 3163 0.0690310915920432 4485 825140
SGTC_3213 9129884 49.47 µM -1.48466418917349 0.056724331285258 no 3164 0.0688164012453462 4460 17190742
SGTC_540 1187-0821 17.3 µM -1.48531108638491 0.0566465974317087 no 3165 0.0687307182180599 4412 847520
SGTC_793 0488-0545 106 µM -1.48543781493666 0.0566313790383806 no 3166 0.068713942369783 4502 292548
SGTC_2891 9063876 19.48 µM -1.48667175416485 0.0564833678670644 no 3167 0.0685507631527934 4516 6472478
SGTC_2252 omeprazole 400 µM -1.4914512363295 0.0559129437771789 no 3168 0.0679215324019054 4521 4594 A proton pump inhibitor.
SGTC_839 0122-0028 230 µM -1.49420042499349 0.0555868968154641 no 3169 0.0675616207862681 4506 759448
SGTC_2678 equilin 100 µM -1.49844680806903 0.0550862377048407 no 3170 0.0670086013911211 4491 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3016 9080866 49.47 µM -1.49918361600104 0.0549997300548505 no 3171 0.0669130021171629 4465 17066299
SGTC_2638 epoxomicin 18 µM -1.50736599092064 0.0540462474921852 no 3172 0.0658584355403565 4468 9915668 A protesome inhibitor.
SGTC_563 tetrahydrosecaminediol 614 µM -1.50815028116498 0.0539555464930158 no 3173 0.0657580344203655 4544 334274 A psychoactive constituent of the cannabis plant.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.50921477591395 0.0538326334412322 no 3174 0.0656219526996972 4499 688662
SGTC_943 3253-1379 105 µM -1.52199100988148 0.0523746494238422 no 3175 0.0640056666624411 4481 668464
SGTC_2298 7976326 193.81 µM -1.52257098643375 0.0523092156187134 no 3176 0.063933036562026 4461 2235818
SGTC_3272 9137413 49.47 µM -1.5232290900697 0.0522350460378411 no 3177 0.0638507002975937 4449 17614870
SGTC_978 1416-0512 87.4 µM -1.52835171102781 0.0516605680434439 no 3178 0.063212618656931 4548 6814003
SGTC_389 tpck 16.7 µM -1.5291925730482 0.0515667510280905 no 3179 0.0631083556149857 4547 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3007 9078383 71.4286 µM -1.53136142779663 0.0513253919225058 no 3180 0.0628400457776266 4517 6496995
SGTC_665 3914-0008 307 µM -1.53448051536108 0.0509798634356081 no 3181 0.0624557415677554 4477 1069549
SGTC_179 1273-0063 6.77 µM -1.53495059977237 0.0509279490225666 no 3182 0.0623979814903317 4482 3108139
SGTC_2235 salicylic acid 500 µM -1.53970405329686 0.0504053561169374 no 3183 0.0618162541872296 4576 338 A COX inhibitor and kinase inhibitor.
SGTC_730 1436-0052 41.2 µM -1.54032182311571 0.0503377536134783 no 3184 0.0617409634217911 4549 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1866 st057638 64 µM -1.54052866883288 0.0503151346560957 no 3185 0.0617157700814419 4534 688802
SGTC_1158 4092-0494 91.8 µM -1.54766429207935 0.0495397886833474 no 3186 0.0608515717353369 4596 1148199
SGTC_2983 9022671 12.99 µM -1.54942805336634 0.0493496183536007 no 3187 0.060639427175981 4504 6405161
SGTC_202 3594-0513 34.79 µM -1.55108640333746 0.0491713456200861 no 3188 0.060440489560749 4596 708429
SGTC_1578 josamycin 24.2 µM -1.55161099124022 0.0491150595899282 no 3189 0.0603776658162037 4515 5282165 A P450 substrate.
SGTC_138 0850-0259 40.9225 µM -1.55372393337297 0.0488888708654409 no 3190 0.0601251408206973 4473 6813004
SGTC_2999 9069765 71.4286 µM -1.55876889177435 0.0483521779078064 no 3191 0.0595255447496333 4475 2097066
SGTC_2567 aureobasidin a 60 nM -1.56517196696366 0.0476778034620529 no 3192 0.0587712963415141 4587 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2829 7992743 58.44 µM -1.56804290826853 0.0473778906872049 no 3193 0.058435559457399 4509 16462845
SGTC_2212 7123476 200 µM -1.5686100162279 0.0473188269570419 no 3194 0.0583694185629925 4575 1085715
SGTC_1250 0485-0349 40.2 µM -1.56991458877271 0.0471831810185147 no 3195 0.058217491554576 4522 6842794 YDL195W SEC31
SGTC_196 k015-0023 18.111 µM -1.58024800203318 0.0461197218463933 no 3196 0.0570250413777147 4495 5211998
SGTC_2505 galangin 7.89 µM -1.58105176879976 0.0460378160494102 no 3197 0.0569331006952961 4461 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_561 1550-0330 72.9 µM -1.58106003792384 0.046036974013125 no 3198 0.0569321554197681 4501 6812934
SGTC_529 4076-0302 30.3 µM -1.58345754358865 0.0457933598307421 no 3199 0.0566586081181953 4503 5816522
SGTC_22 0964-0034 14.468 µM -1.58593264446878 0.0455429490824478 no 3200 0.05637729481229 4548 138402
SGTC_247 mechlorethamine 29.705 µM -1.58715089765128 0.0454201010114845 no 3201 0.0562392363191031 4509 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_537 1334-0398 209 µM -1.59493433452391 0.0446415009773919 no 3202 0.0553634603577219 4562 5846986
SGTC_745 0469-0705 296 µM -1.60329634120789 0.0438170407416743 no 3203 0.0544346219487338 4569 3486736
SGTC_66 0109-0187 42.4 µM -1.60374447510031 0.0437732056495237 no 3204 0.0543851940663827 4405 759417
SGTC_2324 6149169 200 µM -1.60622372901648 0.0435313314902584 no 3205 0.0541123807222717 4504 2888231
SGTC_969 1313-0238 134 µM -1.61005706052966 0.0431594790346952 no 3206 0.0536927000054524 4574 5212874
SGTC_316 k060-0003 58.6 µM -1.61150393595945 0.0430197935128773 no 3207 0.0535349650174857 4591 6152314
SGTC_3318 9139014 38.6185 µM -1.61424718353812 0.0427559553477223 no 3208 0.0532369106448054 4542 16643984
SGTC_3117 9124945 49.47 µM -1.61801761560773 0.0423954612576051 no 3209 0.0528294007002087 4476 17592065
SGTC_2902 5787006 60.46 µM -1.62343829091526 0.0418814983490545 no 3210 0.0522478724273263 4528 591003
SGTC_3003 9075612 71.4286 µM -1.62483991918914 0.0417494266856683 no 3211 0.0520983363659241 4570 6501993
SGTC_2933 9026794 32.47 µM -1.62633995544101 0.04160845617082 no 3212 0.0519386782340731 4498 17586027
SGTC_14 0354-0009 295 µM -1.63693912184779 0.0406233219887995 no 3213 0.0508215952461272 4656 1713507
SGTC_1738 st035555 74 µM -1.63787183161973 0.0405375456918137 no 3214 0.0507242165693096 4556 5331140
SGTC_3263 9137018 49.47 µM -1.64814786167138 0.0396022141935959 no 3215 0.0496611664259163 4520 43844957
SGTC_3202 9113761 49.47 µM -1.65144957808809 0.0393054422189921 no 3216 0.0493234042320762 4492 4798415
SGTC_3236 9132701 49.47 µM -1.6535890166211 0.0391141086747917 no 3217 0.049105522916915 4583 24282524
SGTC_2970 9090938 41.86 µM -1.65501359706067 0.0389871270897729 no 3218 0.0489608699087 4598 17217104
SGTC_2474 5321570 43.32 µM -1.65510437240001 0.0389790471164091 no 3219 0.0489516640600805 4576 2841384
SGTC_3177 9107506 49.47 µM -1.65592971927305 0.038905644982832 no 3220 0.0488680261471021 4545 8897194
SGTC_452 diindolylmethane 8 µM -1.66297737993449 0.038283436130157 no 3221 0.0481584817467817 4565 3071 Inhibits expression of several cancer promoting factors.
SGTC_286 k060-0067 22.9 µM -1.67026450676435 0.0376486419965003 no 3222 0.0474335211254311 4610 5985051
SGTC_3319 9138450 16.7555 µM -1.67203504091602 0.0374957123259817 no 3223 0.0472587062641635 4522 2029690
SGTC_931 2812-0076 566 µM -1.67552283694259 0.0371959383410409 no 3224 0.0469158471158801 4515 3450959
SGTC_2862 9027634 71.43 µM -1.68078658136575 0.0367472332337634 no 3225 0.0464021879882768 4543 5012562
SGTC_2469 5655019 90.81 µM -1.68466322860724 0.0364196091746704 no 3226 0.0460267824012909 4637 2788239
SGTC_340 k038-0059 454 µM -1.68913821066487 0.036044394930208 no 3227 0.0455964733781433 4571 23733424
SGTC_26 0302-0163 425.158 µM -1.68955160231703 0.0360098935655592 no 3228 0.0455568858616946 4643 3100915
SGTC_1836 st055642 81 µM -1.68998946021289 0.0359733797682552 no 3229 0.045514985532796 4566 8571
SGTC_671 0560-0003 407 µM -1.69328164248973 0.0356998086949507 no 3230 0.0452009353414723 4556 3238678
SGTC_2994 9053520 71.4286 µM -1.70188425427977 0.0349929969595843 no 3231 0.0443885340099889 4589 4647384
SGTC_185 k048-0037 25.491 µM -1.70675096358933 0.0345982494063756 no 3232 0.0439341751294027 4637 6827589
SGTC_1573 oleylamine 1.06 µM -1.7146000235157 0.0339693099682791 no 3233 0.0432092922191372 4580 5356789 An amine of the fatty acid oleic acid.
SGTC_1398 3558-0053 112 µM -1.71557233322206 0.0338920582003915 no 3234 0.0431201729455401 4584 4532369
SGTC_1094 duloxetine 25.4 µM -1.7161477364849 0.0338464094732512 no 3235 0.043067503011263 4603 60834 A selective serotonin reuptake inhibitor.
SGTC_1399 3562-5772 25 µM -1.72734636262405 0.0329680093965831 no 3236 0.0420527386949939 4607 23847490
SGTC_2473 5854593 8.94 µM -1.73042569071292 0.0327297930797005 no 3237 0.041777123545916 4579 2872951
SGTC_1917 st066507 28.5 µM -1.73090739843979 0.0326926569375323 no 3238 0.0417341409324396 4530 3156428
SGTC_485 niflumic acid 177 µM -1.74323193661677 0.0317542800270212 no 3239 0.0406465544895191 4636 4488 A COX2 inhibitor.
SGTC_858 0438-0351 2.77 µM -1.74703595784985 0.0314691806320101 no 3240 0.0403155504899357 4598 2799119
SGTC_2200 6600604 21.907 µM -1.75403317701213 0.0309502875954257 no 3241 0.0397124112217674 4638 2904777
SGTC_2056 5235370 200 µM -1.75695209696588 0.0307359321202426 no 3242 0.0394629872978462 4528 5511916
SGTC_2819 7996655 46.38 µM -1.75841533944016 0.0306289400129103 no 3243 0.0393384325013486 4584 6456960
SGTC_3270 9137563 49.47 µM -1.76156504729591 0.0303996800930862 no 3244 0.0390714068899125 4611 17015724
SGTC_622 1348-1566 26.3 µM -1.76398695044546 0.0302243639251484 no 3245 0.0388670881334058 4613 7340407
SGTC_2032 5185112 25.99 µM -1.76660011841778 0.030036143271054 no 3246 0.0386476105757304 4495 5718189
SGTC_1192 1488-0095 21.4 µM -1.76669817892512 0.0300290991545957 no 3247 0.038639394262713 4639 915875
SGTC_3059 1327-0034 3 µM -1.77565153982091 0.0293916883231337 no 3248 0.0378951846941145 4472 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2888 9058547 12.99 µM -1.77910841306954 0.0291486103186679 no 3249 0.0376109948370453 4555 16476514
SGTC_230 MPP+ 141.667 µM -1.78223197044291 0.0289304087417519 no 3250 0.037355705642598 4601 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2642 cholecalciferol 100 µM -1.79264328013681 0.0282128905191639 no 3251 0.0365149906489118 4625 9821465 A vitamin D precursor, similar to steriods.
SGTC_167 3672-0051 66.205 µM -1.79545186448174 0.0280218878982534 no 3252 0.0362908677194241 4550 3237971
SGTC_1361 1608-0041 5.61 µM -1.79799874631875 0.0278496150098354 no 3253 0.0360886032211285 4634 X1361
SGTC_557 1315-0110 16.2 µM -1.80108368980661 0.0276421297754537 no 3254 0.0358448450396292 4606 6833801
SGTC_1436 4092-1007 8.32 µM -1.83360518577271 0.0255321707861753 no 3255 0.0333563109473605 4651 2881121
SGTC_1463 k081-0032 34.1 µM -1.83410530569755 0.0255008070722361 no 3256 0.0333191820014137 4144 977755
SGTC_687 k029-0044 34.9 µM -1.83519654719032 0.0254324847056159 no 3257 0.0332382862841112 4673 5829338
SGTC_3129 9127257 49.47 µM -1.84735257084795 0.0246817120445054 no 3258 0.0323480291968563 4593 837894
SGTC_1950 st077106 7.18 µM -1.85237053632363 0.024377263601954 no 3259 0.031986316597907 4561 13831864
SGTC_331 k048-0133 24.5 µM -1.85480538781281 0.0242306769136205 no 3260 0.0318120111957459 4636 6813582
SGTC_1694 st024011 44.9 µM -1.86147766448425 0.0238327714850179 no 3261 0.0313383759690167 4679 2787533
SGTC_473 2-arachidonoylglycerol 10 µM -1.86797659190859 0.0234504987864258 no 3262 0.0308826668880551 4520 5282280 An endocannabinoid.
SGTC_1162 k048-0130 20.1 µM -1.86900557865138 0.0233904485023503 no 3263 0.03081101912302 4650 6797406
SGTC_198 3454-2873 16.191 µM -1.8735512106351 0.023126717705495 no 3264 0.0304961540357337 4652 710957
SGTC_313 3474-0040 5.03 µM -1.87541299014731 0.0230194250868116 no 3265 0.0303679647080241 4662 1043375 YIL048W NEO1
SGTC_2192 5915882 198.485 µM -1.87816010297251 0.0228618773905913 no 3266 0.0301796331253966 4665 2876149
SGTC_2856 9022925 19.48 µM -1.8786746403539 0.0228324697680128 no 3267 0.0301444662784041 4649 4944862
SGTC_2617 dihydrotanshinone i 20.83 µM -1.8863647704621 0.0223967361295867 no 3268 0.0296229082731442 4595 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_42 0133-0086 60.653 µM -1.88672478695032 0.022376510131627 no 3269 0.0295986759911575 4557 162923 Model of phenazepam hydroxylation.
SGTC_1169 aniline yellow 25.8 µM -1.90080213719184 0.0215976273708804 no 3270 0.0286639670237233 4615 6051 A DNA damaging agent.
SGTC_1271 0832-2808 169 µM -1.93956040170734 0.0195706306044815 no 3271 0.0262165685977421 4689 3663794
SGTC_2248 tofa 1.1 µM -1.93959632368364 0.0195688295968536 no 3272 0.0262143840067635 4688 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2262 9014885 67.46 µM -1.94296302174923 0.0194006582634688 no 3273 0.02601031317849 4704 6457424
SGTC_38 0929-0051 58.268 µM -1.94852880562637 0.0191253325503259 no 3274 0.025675860769421 4626 1379719
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.9544619811834 0.0188354980398426 no 3275 0.025323303418565 4661 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.9806747109491 0.0175993310607751 no 3276 0.0238138822728721 4650 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.98213413854005 0.0175325899070136 no 3277 0.0237321147972429 4698 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_731 3966-0296 387 µM -1.9983518013741 0.0168053652306577 no 3278 0.0228392665755311 4699 660956
SGTC_2841 9004761 38.96 µM -2.01071337662518 0.0162685248791914 no 3279 0.0221778701451992 4622 2991039
SGTC_1082 camptothecin 424.86 nM -2.01090837458664 0.0162601755504939 no 3280 0.0221675678120659 4580 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1697 st025554 27.742 µM -2.04428653798155 0.0148840497928336 no 3281 0.0204626241814033 4714 1269519
SGTC_3011 9081274 71.4286 µM -2.048251209147 0.0147274463782005 no 3282 0.0202676955304439 4700 6625322
SGTC_1964 st076914 61 µM -2.06353070332533 0.014137096818951 no 3283 0.0195311168938493 4725 24208661
SGTC_1977 st070720 65.3 µM -2.06622564861996 0.0140351165017423 no 3284 0.0194035890533095 4698 682188
SGTC_1954 st077032 68.9 µM -2.06889038461587 0.0139349034226504 no 3285 0.0192781870469304 4642 698907
SGTC_2052 5265182 7.135 µM -2.0756385623136 0.0136838788902434 no 3286 0.0189636960434018 4667 1239884
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.09165811950727 0.0131035436025972 no 3287 0.0182345547203957 4695 3256 An antibiotic and ribosome inhibitor.
SGTC_3056 9094900 49.47 µM -2.09265710365627 0.0130680690706179 no 3288 0.0181898875502545 4676 25236784
SGTC_1135 dihydrocapsaicin 536.708 nM -2.10118554788213 0.0127685836542289 no 3289 0.0178123407731005 4639 107982 A Capsaicinoid.
SGTC_2588 indole-3-carbinol 100 µM -2.10376658922739 0.012679126085777 no 3290 0.0176994062933349 4682 3712 Induces cell cycle arrest.
SGTC_1020 4335-0961 93.3 µM -2.10799704353863 0.0125336736263814 no 3291 0.0175156225820138 4683 669075
SGTC_3179 9107801 49.47 µM -2.14661962145231 0.0112712106938951 no 3292 0.0159117882583105 4708 4818259
SGTC_1730 st033808 45.1 µM -2.14862354453034 0.0112088373600561 no 3293 0.0158321268770868 4654 1045166
SGTC_2400 5203494 178.7 µM -2.15308741262972 0.0110709744997922 no 3294 0.0156559046612596 4645 6777674
SGTC_945 3381-0768 11.3 µM -2.16416616723586 0.0107351714591885 no 3295 0.0152257994193877 4705 1126236 YIL048W NEO1
SGTC_2199 6590217 200 µM -2.18588243390904 0.0101025921973155 no 3296 0.0144121038578868 4732 703109
SGTC_3317 9138495 8.753 µM -2.18611949148422 0.0100958702879888 no 3297 0.0144034321616496 4674 17020139
SGTC_1781 st038725 66.3 µM -2.19460104884216 0.00985792449551424 no 3298 0.0140961141266996 4708 4270275 YIL048W NEO1
SGTC_3351 9150312 21.596 µM -2.19679826981631 0.00979708703204429 no 3299 0.0140174283519893 4671 4904905
SGTC_2028 5153890 36.43 µM -2.1993657259475 0.00972641407318694 no 3300 0.0139259638317693 4709 2830968 YPR165W RHO1
SGTC_19 0279-0214 38.434 µM -2.21544515855902 0.00929385196165224 no 3301 0.0133647623162806 4766 3566274 YBR002C RER2
SGTC_1201 1889-3372 45.9 µM -2.22763013163272 0.00897736058906846 no 3302 0.0129525948190746 4669 5392199
SGTC_2827 7993847 71.43 µM -2.23019909680985 0.00891185267672706 no 3303 0.0128671141018315 4727 2985692
SGTC_1965 Pectolinarigenin 58.4 µM -2.24772447793579 0.00847603126818144 no 3304 0.012296882077916 4716 5320438 An anti-inflammatory.
SGTC_2659 sanguinarine 24.21 µM -2.25829511131667 0.00822230228807125 no 3305 0.0119636334386021 4720 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3050 9093513 49.47 µM -2.27259897617242 0.00788959784276252 no 3306 0.0115251786994558 4706 25236664
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.28287396971824 0.00765796855001714 no 3307 0.0112188965969003 4740 16623 A steroid.
SGTC_1579 chlormadinone acetate 49.4 µM -2.34705624627999 0.00634201767149459 no 3308 0.00946119902536686 4767 45114258 A steroidal progestin.
SGTC_372 0155-0182 15.9 µM -2.36601970770019 0.00599358285064782 no 3309 0.00899024362643071 4642 771486
SGTC_1835 st008666 49.2 µM -2.37441312046148 0.00584485709583818 no 3310 0.00878843606453646 4734 690455
SGTC_2570 licareol 100 µM -2.38645811760024 0.00563714840075591 no 3311 0.00850577246822711 4712 443158
SGTC_401 neomycin 50 µM -2.38667059326514 0.00563354397760234 no 3312 0.00850085868466491 4751 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3355 9151058 44.0485 µM -2.39013637457196 0.00557503894724512 no 3313 0.00842105883728737 4752 17015728
SGTC_824 1304-0008 100 µM -2.4084360279655 0.00527498538718404 no 3314 0.00801051689602848 4750 768245
SGTC_2663 amphotericin b 100 µM -2.41053613505755 0.00524148636362277 no 3315 0.00796454664915861 4762 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2114 5491910 81.25 µM -2.4235942897954 0.00503740896732113 no 3316 0.00768388163147318 4754 2849228
SGTC_199 4063-0024 41.6 µM -2.4382985863386 0.00481610091230532 no 3317 0.00737828977319656 4786 306215
SGTC_1721 st082152 9.2685 µM -2.43948920221343 0.00479856661337879 no 3318 0.00735402110753285 4729 5296051
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.44472137943176 0.0047221847181407 no 3319 0.00724820415190869 4755 688667
SGTC_428 3448-4153 16.5 µM -2.44914976918913 0.00465838624516301 no 3320 0.00715969464218509 4736 3834874
SGTC_338 4055-0136 114 µM -2.46802587371395 0.00439498570619342 no 3321 0.00679302495413478 4753 2900563
SGTC_423 5-fluorouracil 457 µM -2.49161583359808 0.00408455881226179 no 3322 0.00635817475569418 4727 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.52609955614635 0.00366604939600732 no 3323 0.00576683959129535 4757 6312947
SGTC_3078 9116413 49.47 µM -2.57326470505725 0.0031559647150521 no 3324 0.00503720615045488 4748 17177322
SGTC_3153 9100258 49.47 µM -2.57621409161336 0.00312629894511013 no 3325 0.00499443882003788 4717 25236848
SGTC_1983 st071813 46.9 µM -2.58208666388316 0.00306797736447899 no 3326 0.00491024603106552 4787 11838595
SGTC_1789 tunicamycin 25 nM -2.63294474889009 0.00260245528241947 no 3327 0.0042324058112273 4740 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.66801943395603 0.00231965059613406 no 3328 0.00381499222764252 4717 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1733 st037357 54.9 µM -2.66892020881032 0.00231276907508277 no 3329 0.00380477626540776 4733 1272339 YGL099W LSG1
SGTC_1462 k081-0014 26.5 µM -2.68015352357529 0.00222849082683781 no 3330 0.00367942006742291 4334 3270634
SGTC_1096 rimcazole 32.2 µM -2.74388924114436 0.00180083213548599 no 3331 0.00303580098222759 4780 18528119 A dopamine reuptake inhibitor.
SGTC_2053 5265679 138 µM -2.77796870685861 0.00160415924246758 no 3332 0.00273499429672629 4751 764595
SGTC_1010 4112-3296 15.2 µM -2.79364265609645 0.00152045202437585 no 3333 0.00260590177737826 4780 704384
SGTC_3017 9080681 49.47 µM -2.79821921083387 0.00149677342846299 no 3334 0.0025692612740391 4778 16451914
SGTC_2859 9028643 45.46 µM -2.84577808112842 0.00126987784268357 no 3335 0.00221515290223924 4720 17151580
SGTC_2396 5342950 42.78 µM -2.9237796432239 0.000964865412364246 yes 3336 0.00172904726800347 4770 1886677
SGTC_2531 methyl deoxycholate 70.07 µM -3.02119391950888 0.00067862724277136 yes 3337 0.00125890026579045 4756 16667744 Haematoxylin.
SGTC_3133 9127736 49.47 µM -3.06260242061933 0.000582594221758044 yes 3338 0.00109710686377942 4783 27243420
SGTC_1136 pergolide 1.05886 µM -3.10737528510879 0.000492996615507076 yes 3339 0.000943783050843114 4771 47811 A dopamine receptor agonist.
SGTC_3127 9126946 49.47 µM -3.13337697398917 0.000447002521748964 yes 3340 0.00086403671940697 4780 27243249
SGTC_3001 9076041 71.4286 µM -3.30920335641695 0.000226272400160537 yes 3341 0.000467809269087554 4799 16004211
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -3.35996173882973 0.00018478037766089 yes 3342 0.000389766337344511 4800 689007
SGTC_973 1325-0077 65.9 µM -3.49772980177936 0.000105182142089057 yes 3343 0.000234618131769094 4809 2835149
SGTC_2130 NSC 7 2.4545 µM -3.66450052600134 5.17704076204338e-05 yes 3344 0.000123910865329071 4803 21448
SGTC_2003 4023581 200 µM -3.66883975696519 5.08043504738806e-05 yes 3345 0.000121826866252399 4802 16641307
SGTC_2129 girgensonine 121.053 µM -3.92874461927453 1.58524393371494e-05 yes 3346 4.26952309380609e-05 4797 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_432 NS 1619 61.3 µM -4.22971678129929 3.76158492853806e-06 yes 3347 1.16992852720439e-05 4803 4552 A K+/calcium channel activator.
SGTC_1958 st076513 41.9 µM -4.80869113469728 1.79962238917626e-07 yes 3348 7.59608633177616e-07 4807 732122 YGL099W LSG1
SGTC_439 amiodarone 34.4 µM -4.92600313910189 9.30277929568892e-08 yes 3349 4.19643247896595e-07 4780 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2008 4012253 172 µM -6.2281552420758 2.25540912333839e-11 yes 3350 2.35979647231403e-10 4808 603940