SGTCid condition conc unit YDR282C|YDR282C.score YDR282C|YDR282C.strain.pval YDR282C|YDR282C.strain.significant YDR282C|YDR282C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2799 7812892 81.82 µM 5.36477912394768 7.26359878813231e-10 yes 1 4.05241681381472e-08 13 20205235 SGTC_875 0709-0210 25.7 µM 4.32350648556446 5.41485949297561e-07 yes 2 7.67843107407171e-06 25 6251364 SGTC_65 0798-0905 34.986 µM 4.27682316944744 7.05962637414339e-07 yes 3 9.478963571387e-06 75 3602145 SGTC_2312 7706453 155.7 µM 4.18066301596464 1.20894717701632e-06 yes 4 1.45330173777278e-05 23 976098 SGTC_699 0375-0592 111 µM 4.11223385552263 1.76061296244748e-06 yes 5 1.95924537791813e-05 15 762578 SGTC_867 0518-0118 155 µM 3.97021949622475 3.7717435919946e-06 yes 6 3.59032247453291e-05 20 6848158 SGTC_2329 6138490 200 µM 3.93981490437414 4.42579495548495e-06 yes 7 4.07722499988058e-05 30 720019 SGTC_1354 1498-1681 81 µM 3.91599550973044 5.01252507740622e-06 yes 8 4.50159617316065e-05 19 5754243 SGTC_2993 9054257 71.4286 µM 3.85536563028632 6.85991409019564e-06 yes 9 5.77783943146537e-05 47 6470217 YGL055W OLE1 SGTC_1091 telmisartan 47.6 µM 3.83650346653355 7.55637580971363e-06 yes 10 6.23992176483195e-05 17 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_585 0kpi-0023 191 µM 3.71402854358881 1.40093459069441e-05 yes 11 0.000101992885523916 22 64601 SGTC_570 0987-0065 62.6 µM 3.69242988001586 1.55911063671693e-05 yes 12 0.000111060797258881 10 3104428 SGTC_2999 9069765 71.4286 µM 3.62337888490963 2.18653457491362e-05 yes 13 0.000145389696740789 39 2097066 SGTC_1346 1488-2224 62.4 µM 3.54155470332843 3.24007093252711e-05 yes 14 0.000198888184169923 26 3722427 SGTC_685 1278-0033 54.9 µM 3.42557899187161 5.57968302502477e-05 yes 15 0.000306745256325284 43 3590572 SGTC_749 1000-0129 128 µM 3.4246401545242 5.60391589603694e-05 yes 16 0.000307807110192612 35 708470 SGTC_1309 pyrazolanthrone 13.4 µM 3.4065345348427 6.09112342710391e-05 yes 17 0.000328966131273002 37 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 3.35004933057086 7.88036963226464e-05 yes 18 0.00040398584778636 36 5393153 SGTC_3344 9148862 3.898 µM 3.32988661619267 8.63111818104194e-05 yes 19 0.000434406776077482 26 4905352 SGTC_955 1216-0110 33 µM 3.30377486795646 9.70357845629825e-05 yes 20 0.000476962020586002 105 3619719 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 3.25665828606887 0.000119622087856501 yes 21 0.000563660283655275 109 6708739 YPR165W RHO1 SGTC_288 1315-0019 35.1 µM 3.21731981298722 0.000142167333374391 yes 22 0.000646971376920122 49 6811474 SGTC_824 1304-0008 100 µM 3.14580546165772 0.000193666725507182 yes 23 0.000828150675439282 72 768245 SGTC_431 k089-0097 107 µM 3.04481561109164 0.000296557574258994 yes 24 0.00116411501369154 95 5499420 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 3.04217014224772 0.000299837061843538 yes 25 0.00117439545323615 144 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1368 1852-0141 284 µM 2.95022560033681 0.000437150668036841 yes 26 0.00158770985182732 85 2838987 SGTC_2381 9035592 200 µM 2.93270670313105 0.000469173956416947 yes 27 0.00168010580460376 61 4749657 SGTC_421 streptovitacin 30 mM 2.89640371751172 0.000542564143476515 yes 28 0.00188733226014802 83 91467 include heat shock SGTC_1040 k898-0338 155 µM 2.8896938107119 0.000557240209893282 yes 29 0.0019280860996578 67 20969351 SGTC_1359 1582-0056 520 nM 2.8628112278107 0.000619795935011391 yes 30 0.0020995032474314 72 3661189 SGTC_1248 0469-0687 58.6 µM 2.84317998040255 0.000669507497094227 yes 31 0.00223329198628839 94 4017482 SGTC_1089 terbinafine 2.25 µM 2.84079855074431 0.000675781892165708 yes 32 0.0022500364541921 70 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2398 5228213 48.84 µM 2.80638581616261 0.00077271658649622 yes 33 0.00250503326338143 124 80771 YMR134W ERG29 SGTC_1210 3013-0140 750 nM 2.79793282274432 0.000798410364953819 yes 34 0.00257154040597298 51 905973 SGTC_2057 5236571 38.335 µM 2.72977452769395 0.00103616056279975 no 35 0.00316888278520421 120 54684039 YBR257W POP4 SGTC_639 0833-0042 114 µM 2.6782738783911 0.00125712260695647 no 36 0.00370013402298226 127 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_874 0599-0792 117 µM 2.67254219768778 0.00128421153773722 no 37 0.00376394529766984 110 765305 SGTC_1968 st069590 43.6 µM 2.6583770423165 0.00135346368356345 no 38 0.00392589979121166 66 6384066 SGTC_2167 5876490 200 µM 2.65175110909567 0.00138701441458465 no 39 0.0040037772394136 111 686534 SGTC_2389 9091542 195.52 µM 2.64187744883829 0.00143842116500865 no 40 0.00412239412592099 120 3626624 YOL127W RPL25 SGTC_1399 3562-5772 25 µM 2.61137124791359 0.00160843238960571 no 41 0.00450899688699634 70 23847490 SGTC_1504 k297-0033 30 µM 2.59653621220399 0.00169755607569232 no 42 0.00470844894541174 83 4388117 SGTC_1211 1056-0033 32.3 µM 2.58923470843978 0.00174305176871186 no 43 0.00480947538648395 68 6741922 SGTC_2605 digitonin 300 nM 2.53812505173076 0.00209386733874991 no 44 0.00557240768198751 138 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_694 1315-0438 43.2 µM 2.52653512420644 0.00218184066900111 no 45 0.00575969344721244 76 6793154 SGTC_1299 1079-1439 3.74 µM 2.52588947219502 0.00218683862359678 no 46 0.00577028914393493 94 323161 SGTC_1472 k841-0093 193 µM 2.51151461329848 0.00230083558462314 no 47 0.00601071542895705 122 X1472 SGTC_2064 5220758 200 µM 2.49923796484577 0.00240242472654528 no 48 0.00622303523703702 146 788518 SGTC_1704 st028805 70.8 µM 2.48538120953125 0.00252195225788306 no 49 0.00647063851082699 84 2876101 SGTC_2021 4019055 173 µM 2.48126130239231 0.00255851305455019 no 50 0.00654591808162334 287 44827708 YER133W GLC7 SGTC_2161 5662504 8.5105 µM 2.47347638370042 0.00262890824474663 no 51 0.00669028237027541 119 2859334 SGTC_879 0831-1030 162 µM 2.46855591780584 0.0026742992739556 no 52 0.00678297275179606 184 1549252 SGTC_833 3852-0053 558 µM 2.42629701139725 0.00309424139177106 no 53 0.00762689043585839 122 3123681 SGTC_772 k072-0172 35.3 µM 2.38242672400092 0.00359214934601434 no 54 0.00859947724919215 124 5861980 SGTC_290 2043-6722 48.1 µM 2.34284822541479 0.00410183570454525 no 55 0.00956858311229723 139 773758 YLR208W SEC13 SGTC_1128 3448-9350 235 µM 2.34057698373891 0.00413295803205124 no 56 0.00962698425310299 151 619386 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.33543932451153 0.00420413907122457 no 57 0.00976024106274239 123 689007 SGTC_587 k089-0003 57 µM 2.32798370809087 0.00430938530187085 no 58 0.00995648438996137 56 9659696 SGTC_1604 st002052 72.4 µM 2.31341966308826 0.00452179360417547 no 59 0.0103497885154844 138 6254834 YHR062C RPP1 SGTC_3010 9080089 71.4286 µM 2.29619445554055 0.00478504351490303 no 60 0.0108323827132277 136 17027233 SGTC_1569 carminic acid 40.6 µM 2.27058585446966 0.00520169457936361 no 61 0.0115860302926139 152 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3018 9082602 49.47 µM 2.26130040621045 0.00536056221809361 no 62 0.011870330553194 160 17332089 SGTC_164 4100-3994 89.624 µM 2.25669229117076 0.00544099416508681 no 63 0.0120136544401189 204 4615967 SGTC_219 mitoxanthrone 164.414 µM 2.25081290898478 0.00554517163385717 no 64 0.0121986947913597 180 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_696 1560-0013 611 µM 2.24128204616273 0.00571781763585726 no 65 0.012503905586588 159 1650269 SGTC_2277 7947813 106.88 µM 2.22658572717625 0.00599338994111853 no 66 0.0129874868647629 181 1246798 SGTC_108 0509-0257 621.132 µM 2.22002560513957 0.00612015529456408 no 67 0.0132085147739777 225 536624 SGTC_345 1362-0200 395 µM 2.19893516578534 0.00654394226262944 no 68 0.0139412663471407 164 1419823 SGTC_230 MPP+ 141.667 µM 2.19518161381628 0.00662202770759559 no 69 0.0140752863135329 163 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1377 2944-0135 198 µM 2.18054856678914 0.0069343615957008 no 70 0.014608411447454 206 1894137 SGTC_2462 5162487 171.77 µM 2.17390215595332 0.00708047103491992 no 71 0.0148562420548641 167 2259986 SGTC_959 1222-0044 107 µM 2.16711631006259 0.00723244168839368 no 72 0.0151129932893755 181 6083612 SGTC_2275 7947463 200 µM 2.16500298582901 0.00728035390655287 no 73 0.0151937283072272 157 1225414 SGTC_1596 piperlongumine 63 µM 2.16109590523523 0.00736967063634039 no 74 0.0153439659127534 169 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_265 mycophenolic acid 32.932 µM 2.16102293924436 0.00737134780123686 no 75 0.0153467837397193 194 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1979 st071809 45.3 µM 2.16026652108954 0.00738875433338075 no 76 0.0153760215594466 150 4976333 SGTC_370 0180-0345 38.7 µM 2.14637904336783 0.00771483051860431 no 77 0.0159213749561507 158 3989527 SGTC_917 harmaline 728.087 nM 2.12125697888276 0.00833697817189151 no 78 0.0169500913124692 200 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_816 0325-0417 81.3 µM 2.11658773595188 0.00845734676388637 no 79 0.0171474259356972 163 68101 SGTC_2002 4023503 131 µM 2.11258315855858 0.00856179322101901 no 80 0.0173182307236879 250 4736863 YCR052W RSC6 SGTC_538 2922-0838 53.3 µM 2.10858283144082 0.0086672569659114 no 81 0.0174903030511657 233 777039 SGTC_1707 st032323 6.317 µM 2.08261559443496 0.00937996191990686 no 82 0.0186431383053328 264 3132057 YMR211W DML1 SGTC_159 3970-0959 50 µM 2.08052347026318 0.00943955378509217 no 83 0.0187387725912052 399 6615653 SGTC_1561 5-methoxyflavone 52.9 µM 2.05155810305624 0.0102992653016846 no 84 0.0201063137269063 120 94525 SGTC_2432 5630864 12.22 µM 2.05076069870811 0.0103238683822302 no 85 0.0201451283087088 233 5714970 SGTC_1506 4226-2149 212 µM 2.04989193807128 0.0103507313988747 no 86 0.020187488549378 247 991114 SGTC_2354 9060492 162 µM 2.04615225087812 0.0104670634957045 no 87 0.0203706967706586 218 6471895 SGTC_2920 7982904 15.77 µM 2.04432964205744 0.0105241720224219 no 88 0.0204604963970164 203 6456808 SGTC_2362 9071156 126 µM 2.04346659544771 0.0105513087898504 no 89 0.0205031354471876 203 653133 SGTC_218 alverine citrate 93.75 µM 2.04032765513776 0.0106505211901902 no 90 0.0206588510639007 169 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_911 3456-4043 236 µM 2.03839631602682 0.0107119678923234 no 91 0.0207551572143938 251 914281 SGTC_1473 k844-0725 134 µM 2.03561017552717 0.0108011544029699 no 92 0.0208947576006844 220 54682906 SGTC_2415 st077333 57.7 µM 2.02670373020797 0.0110906065023662 no 93 0.0213463603863293 309 2766255 SGTC_365 0121-0052 13.6 µM 2.0202283230804 0.0113052653614556 no 94 0.0216798548465008 319 3101739 SGTC_1559 coumarin 343 70.1 µM 2.0076047834608 0.0117341329305077 no 95 0.0223426529264221 178 108770 A hepatotoxic, DNA x-linker. SGTC_401 neomycin 50 µM 1.9859894782258 0.0125013121135475 no 96 0.0235172461166833 189 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1965 Pectolinarigenin 58.4 µM 1.98365686182289 0.0125866425729281 no 97 0.0236470528219453 202 5320438 An anti-inflammatory. SGTC_3042 9091578 49.47 µM 1.96755034087733 0.0131897173960778 no 98 0.024559899146353 144 25236497 SGTC_1556 plumbagin 1.48 µM 1.96569326442776 0.0132608315732781 no 99 0.024667026671687 177 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1956 st077085 54 µM 1.95976602010079 0.013490027264929 no 100 0.0250115722902934 265 24208685 SGTC_1451 4152-0210 104 µM 1.95588508316766 0.0136419417430597 no 101 0.0252393464659569 259 659563 SGTC_2272 7805186 180 µM 1.9463549628884 0.014021263521015 no 102 0.0258060577837106 194 2956062 YPR165W RHO1 SGTC_2269 7935389 174.42 µM 1.94618016959433 0.0140283047744335 no 103 0.0258165505579191 233 97605 SGTC_2675 theaflavin digallate 100 µM 1.93602581866829 0.0144426210155131 no 104 0.0264322694384978 246 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_311 1315-0136 58 µM 1.9351861919063 0.0144773461127626 no 105 0.0264837257797652 204 6759207 SGTC_946 3434-1334 87.4 µM 1.93387533306703 0.0145317040124493 no 106 0.0265642288104135 227 4047976 SGTC_976 1348-1067 47.6 µM 1.93213887436073 0.0146039808332285 no 107 0.0266711836484733 263 5310671 YGL099W LSG1 SGTC_826 1683-5028 118 µM 1.92988448891074 0.0146982767112051 no 108 0.0268105758668374 210 722377 SGTC_848 0368-0089 85.6 µM 1.9239250155499 0.0149500743005471 no 109 0.0271819915641361 243 762535 SGTC_822 1487-0950 154 µM 1.91347005422649 0.015400777323282 no 110 0.027843951792577 247 1958375 SGTC_435 c-PAF 6.7 µM 1.91338762636403 0.0154043765557894 no 111 0.0278492236355966 278 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2536 dehydroabietamide 32.04 µM 1.91262941387588 0.0154375179755664 no 112 0.0278977556856341 265 3983547 SGTC_2453 5731132 22.18 µM 1.908043636193 0.0156392694951833 no 113 0.0281927883136592 246 1362040 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.90091554809474 0.0159573603180156 no 114 0.0286565376108795 318 368090 SGTC_1392 3455-1037 33.9 µM 1.89832090145631 0.0160745153556875 no 115 0.0288269111157963 237 981132 SGTC_1904 st060225 78 µM 1.87828083847108 0.0170044571668116 no 116 0.0301713782202191 233 66595 SGTC_2970 9090938 41.86 µM 1.86927325247533 0.0174372023256392 no 117 0.0307924037162035 361 17217104 SGTC_1135 dihydrocapsaicin 536.708 nM 1.8678087920347 0.017508439705362 no 118 0.0308943637659297 295 107982 A Capsaicinoid. SGTC_115 0527-0192 112.043 µM 1.85089006250171 0.0183496132456526 no 119 0.0320926853415714 388 4233931 SGTC_705 1124-0212 310 µM 1.8479602147835 0.0184987239031761 no 120 0.032304049261773 287 9554485 SGTC_2481 5478948 45.16 µM 1.84188698128426 0.0188111013968422 no 121 0.0327458416507658 280 77792 SGTC_277 nystatin 15.5 µM 1.83995474832172 0.0189114224808576 no 122 0.0328874405789241 281 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1620 st003704 16.5 µM 1.83611978575865 0.0191118813354064 no 123 0.0331699713245018 220 2834414 SGTC_532 1548-0774 215 µM 1.83196739552297 0.0193309668149283 no 124 0.0334781391820636 282 5932993 SGTC_143 4032-1194 15.74 µM 1.82474137800604 0.0197173096924774 no 125 0.0340200329694969 373 1806963 SGTC_2549 cedrol 20.94 µM 1.81744793718552 0.0201138846145077 no 126 0.0345742766410555 213 6708665 A sedative which affects the nervous system. SGTC_1166 k206-0078 225 µM 1.81683200483376 0.0201476830458438 no 127 0.0346214203137576 307 5404595 SGTC_3093 9117344 49.47 µM 1.8115596589522 0.0204389712110288 no 128 0.0350271315004906 254 24824913 SGTC_2073 5212005 126 µM 1.81050919674246 0.0204974318354979 no 129 0.0351084297323719 179 691789 SGTC_2450 5739737 12.93 µM 1.81011985979121 0.0205191352844032 no 130 0.0351386009165576 267 2262825 SGTC_1860 st056228 74.6 µM 1.80486696980497 0.0208138643011227 no 131 0.0355477507903997 265 688679 SGTC_287 k060-0039 29.6 µM 1.80083970913085 0.0210422460065717 no 132 0.0358640740284606 261 5861974 SGTC_682 0kpi-0099 17 µM 1.79824861594554 0.0211903023744751 no 133 0.0360688092703399 339 1714895 YML126C ERG13 SGTC_2324 6149169 200 µM 1.79600060251467 0.0213194679761971 no 134 0.0362472106032019 248 2888231 SGTC_381 3461-2219 42.7 µM 1.79313866423946 0.0214848710341246 no 135 0.0364753773102282 302 2883159 SGTC_2309 7664088 163.95 µM 1.79086047210553 0.0216173112322825 no 136 0.0366578441036356 342 704922 SGTC_942 3253-1115 227 µM 1.76785082061643 0.0229940469795809 no 137 0.0385429231401561 301 46497897 SGTC_1388 3346-4487 254 µM 1.7667368812856 0.0230625300531173 no 138 0.0386361518534806 318 3345614 SGTC_1711 st032263 62.8 µM 1.760722549616 0.023435254767501 no 139 0.0391426870976785 274 3958979 SGTC_2143 5623677 140.463 µM 1.75504982221946 0.023791441307081 no 140 0.0396253930391407 235 5375313 SGTC_2237 6667747 47.222 µM 1.75467665688267 0.0238150307832934 no 141 0.0396573155224571 262 729940 YDL015C TSC13 SGTC_3204 9114183 49.47 µM 1.75400026342557 0.0238578388064565 no 142 0.0397152310040508 309 17027248 SGTC_1004 4084-0029 199 µM 1.75180680694217 0.0239971049060698 no 143 0.0399035166799237 303 716894 YLR208W SEC13 SGTC_2692 st077426 47.7 µM 1.74743573773059 0.0242766687438786 no 144 0.0402808914347629 308 25238571 SGTC_2701 st077767 14.721 µM 1.74650823558502 0.0243363401363709 no 145 0.0403613386362444 362 5721188 SGTC_3073 9114972 49.47 µM 1.74314294381143 0.0245538831809295 no 146 0.0406543244553688 263 41905075 SGTC_1185 1319-0113 81.3 µM 1.73674887688401 0.0249717129224903 no 147 0.0412157531817517 277 4672763 SGTC_1054 3429-0080 167 µM 1.73010794378123 0.0254119691306032 no 148 0.0418054956127622 351 1162877 SGTC_196 k015-0023 18.111 µM 1.72509521135924 0.0257485745455936 no 149 0.0422551576976622 325 5211998 SGTC_2160 5660466 132.927 µM 1.7226075341296 0.0259170029400486 no 150 0.0424797608128484 288 2859134 SGTC_564 3555-0129 330 µM 1.7088319542005 0.0268664480356178 no 151 0.0437410409275269 229 563260 SGTC_2088 5278280 127.392 µM 1.70838942870963 0.0268974230675206 no 152 0.0437820537312656 355 791502 SGTC_506 n9-isopropylolomoucine 153 µM 1.70442865773275 0.0271759911615398 no 153 0.0441505169088549 295 6610355 SGTC_2742 clothiapine 36.27 µM 1.70256507105754 0.0273078909032184 no 154 0.0443247456758278 249 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2707 st078556 66.6 µM 1.70113371497603 0.0274095606880244 no 155 0.044458940617727 291 17250899 SGTC_336 4111-0029 111 µM 1.6981759888045 0.0276206493529606 no 156 0.0447372754758137 269 3131175 SGTC_1608 st001473 40.5 µM 1.69777436909389 0.0276494165876159 no 157 0.0447751776043594 335 7292267 SGTC_1281 0884-0031 11.8 µM 1.69586878835923 0.0277862501471259 no 158 0.0449553658484273 355 1548255 SGTC_2533 agelasine 13.65 µM 1.68748821052204 0.0283947465912675 no 159 0.0457547574879543 370 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1650 st011916 45.8 µM 1.68675768187102 0.0284483101772935 no 160 0.045824977829986 278 242528 SGTC_2053 5265679 138 µM 1.68327205558375 0.028705040934385 no 161 0.0461612187276595 356 764595 SGTC_2185 6113692 200 µM 1.67413702944986 0.0293870269509863 no 162 0.0470518358757957 301 874150 SGTC_1760 st045453 10.4495 µM 1.67321589865995 0.029456535633811 no 163 0.0471424008112345 428 3323419 YIL048W NEO1 SGTC_1028 k015-0029 4.8 µM 1.6687908636545 0.0297923549717284 no 164 0.0475794170033776 378 4588309 SGTC_387 norethindrone acetate 66.7 µM 1.66522743223357 0.0300650898067392 no 165 0.0479336949979046 307 541197 SGTC_1501 4491-0275 38.4 µM 1.65797813207562 0.0306263219230523 no 166 0.0486609401512981 306 5104718 SGTC_2771 fluoxetine 41.05 µM 1.65469931872771 0.0308829985130042 no 167 0.0489927526720462 306 3386 A selective serotonin reuptake inhibitor. SGTC_1970 st070122 35.8 µM 1.6537166137188 0.0309602738831858 no 168 0.0490925527057828 367 102928 SGTC_628 1636-0253 16 µM 1.65326784268712 0.0309956163444657 no 169 0.0491381822776839 372 4456143 SGTC_747 3448-8087 38.7 µM 1.65137346850704 0.0311451737748858 no 170 0.049331169458496 370 5168703 SGTC_1106 tegaserod maleate 11.7 µM 1.65115400865862 0.0311625382552656 no 171 0.0493535657367567 380 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1540 guanosine 70.6 µM 1.6483636827567 0.031384018297654 no 172 0.0496390319214171 301 6802 Guanosine is a purine nucleoside SGTC_43 0570-0105 72.5 µM 1.64694308787635 0.0314972759973188 no 173 0.0497848721597535 497 1114046 YDL195W SEC31 SGTC_684 1140-0066 328 µM 1.64591856572512 0.0315791661088502 no 174 0.0498902630178322 390 6813534 SGTC_1369 1866-0067 208 µM 1.64527261753841 0.0316308871723811 no 175 0.0499568020260297 406 3531355 SGTC_15 0266-0086 27.098 µM 1.64363543740522 0.0317622897984851 no 176 0.0501257646858684 440 1712902 YIL048W NEO1 SGTC_264 promethazine 12.5 mM 1.64122289597126 0.0319567458113171 no 177 0.0503755773022757 480 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2986 9022445 71.43 µM 1.63565799662324 0.0324090399672856 no 178 0.0509555924785872 349 6459286 SGTC_262 fenpropimorph 62.5 µM 1.62759907213983 0.0330733902448122 no 179 0.0518049630029701 321 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3009 9080819 71.4286 µM 1.62675217238333 0.0331438527132251 no 180 0.0518948716030462 328 17027216 SGTC_3234 9132280 49.47 µM 1.61309435386486 0.0342973689411818 no 181 0.0533620051715221 384 17612295 SGTC_2784 7567673 72.73 µM 1.60735697672992 0.0347916823568098 no 182 0.0539880410883691 413 3471247 SGTC_2898 9056270 58.44 µM 1.59896703436875 0.0355250495006306 no 183 0.0549139638249761 294 19154699 SGTC_1796 st049173 110.4 µM 1.59478825679253 0.0358950185853738 no 184 0.0553797969755169 289 94134 SGTC_2182 6325192 200 µM 1.5917550123447 0.0361655400156207 no 185 0.0557198810640779 334 736248 SGTC_1051 3253-3903 78 µM 1.59045450444998 0.0362820366584762 no 186 0.0558661964623788 408 5509239 SGTC_491 tetrandrine 80.3 µM 1.58798933637993 0.036503703992728 no 187 0.056144375232127 294 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1310 1188-0297 994 nM 1.58579476954283 0.0367019701321458 no 188 0.0563929362954207 383 1588352 SGTC_2130 NSC 7 2.4545 µM 1.58422762827879 0.0368440904512953 no 189 0.0565709641027164 407 21448 SGTC_2156 5649887 115 µM 1.58359035223215 0.0369020120586521 no 190 0.0566434854209728 422 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_680 0417-1641 114 µM 1.57343174919893 0.0378354143450652 no 191 0.0578094401347499 349 2835990 SGTC_1805 st050013 60.3 µM 1.57007889862284 0.0381476805378275 no 192 0.0581983785197075 334 4037144 SGTC_1564 D-Arginine 115 µM 1.56054019526498 0.0390475742859013 no 193 0.0593161394731081 401 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_46 0329-0187a 2.197 µM 1.56015663783171 0.0390841179919321 no 194 0.0593614349534346 500 46494817 SGTC_374 0880-0231 82.3 µM 1.55991242167741 0.0391074003628231 no 195 0.0593902893193994 390 6833587 SGTC_956 1185-0240 191 µM 1.55863304414088 0.0392295545085405 no 196 0.0595416286859508 382 1416193 SGTC_2076 5212012 200 µM 1.5545505201338 0.0396214291346981 no 197 0.0600265779000215 287 604802 SGTC_2840 9008771 71.43 µM 1.55271545156774 0.0397986083807123 no 198 0.0602455646144556 319 2992978 SGTC_2115 tiliquinol 12.7705 µM 1.54923350303231 0.0401365673094235 no 199 0.0606627991930552 353 71208 A bioactive hydroxyquinoline. SGTC_3319 9138450 16.7555 µM 1.54819421448223 0.0402378915611323 no 200 0.0607877719655028 369 2029690 SGTC_2268 7933382 153.85 µM 1.54765350403484 0.0402906896195942 no 201 0.0608528711007033 470 935025 YOR257W CDC31 SGTC_1303 1160-0052 261 µM 1.54263504762286 0.0407834095646795 no 202 0.0614596747029668 397 3562476 SGTC_1022 4477-0945 21.3 µM 1.54221842002257 0.0408245335626064 no 203 0.0615102626901207 407 4648966 SGTC_775 4577-0580 57.3 µM 1.5421491090423 0.0408313782941003 no 204 0.0615186817605712 390 2006902 SGTC_2586 curcumin 80 µM 1.54079033298156 0.0409657509077783 no 205 0.0616839114793148 487 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1305 1181-0477 144 µM 1.54024692465544 0.041019590164647 no 206 0.0617500878644946 381 6252086 SGTC_557 1315-0110 16.2 µM 1.53993518253655 0.0410505025279058 no 207 0.0617880768988958 406 6833801 SGTC_1792 st045773 43.6 µM 1.53608295549694 0.0414340508581225 no 208 0.0622590180185219 401 2919270 SGTC_683 panaxydol 45 µM 1.53387081875026 0.041655612434225 no 209 0.0625307181233956 422 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2151 5563267 85.4165 µM 1.53065130251779 0.0419797841564455 no 210 0.0629277976020702 418 5310824 SGTC_183 3914-0051 30.55 µM 1.52673923397295 0.0423764338977577 no 211 0.0634129336003343 400 1596232 SGTC_1987 st072290 61.9 µM 1.51786322890354 0.0432876296551862 no 212 0.0645244407067238 418 54697379 SGTC_131 0141-0277 33.849 µM 1.51685976394331 0.0433916317140651 no 213 0.0646510470756724 433 1547771 SGTC_1398 3558-0053 112 µM 1.51055267926642 0.0440499435091996 no 214 0.065451229055722 335 4532369 SGTC_1560 lithocholic acid 53.1 µM 1.50644339738062 0.0444831723490384 no 215 0.0659766936259813 307 9903 A bile acid which acts as a detergent. SGTC_2474 5321570 43.32 µM 1.50638672468254 0.0444891710875149 no 216 0.065983963295834 387 2841384 SGTC_3089 9117425 49.47 µM 1.50014082152831 0.0451542968884493 no 217 0.0667889643293373 408 9401657 SGTC_1897 st060201 15 µM 1.49861247313577 0.0453182631803268 no 218 0.0669870974977402 379 611878 SGTC_599 1935-0052 86.5 µM 1.49658643533765 0.0455363611563064 no 219 0.0672504509244527 445 9557311 SGTC_127 0180-0333 59.125 µM 1.49638231043313 0.0455583814188414 no 220 0.0672770283133626 529 771601 SGTC_3149 9097855 49.47 µM 1.49402799743062 0.0458129755977757 no 221 0.0675841508380575 408 25236625 YMR079W SEC14 SGTC_1026 k007-1105 30.6 µM 1.49355496155593 0.0458642671405731 no 222 0.0676459893423214 520 7066794 SGTC_3219 9131112 49.47 µM 1.49111361178417 0.0461297181392842 no 223 0.0679658346004295 405 17612988 YMR079W SEC14 SGTC_1020 4335-0961 93.3 µM 1.49106186010296 0.0461353584919118 no 224 0.067972627290658 396 669075 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.48456288897561 0.0468480873971212 no 225 0.0688298261448113 409 1609 A potent and irreversible inhibitor of serine proteases. SGTC_736 0958-0254 92.6 µM 1.4812309923923 0.0472168994757058 no 226 0.0692725150680215 453 6812352 SGTC_1230 0170-0365 3.77 µM 1.47844501083599 0.0475270668600203 no 227 0.0696443526421715 588 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_717 1532-0246 73.2 µM 1.47737903383268 0.0476461745052581 no 228 0.069787031532283 451 9561992 SGTC_26 0302-0163 425.158 µM 1.47414085786616 0.0480094609501098 no 229 0.0702218348342723 409 3100915 SGTC_1375 2910-0797 186 µM 1.47335167926384 0.0480983329457876 no 230 0.0703281162164431 439 742508 SGTC_129 0088-0017 176.636 µM 1.47131977368058 0.048327758428308 no 231 0.0706023291034662 443 182446 SGTC_1617 st002906 78 µM 1.47098276333808 0.0483658952630319 no 232 0.0706478891912182 461 5150859 SGTC_55 0767-0285 6.563 µM 1.45476341306871 0.0502299439442094 no 233 0.0728673851324738 504 3116166 SGTC_1435 4092-0789 56.7 µM 1.44935640603013 0.050863933025547 no 234 0.0736190381598925 433 2248285 SGTC_2395 5646831 180.19 µM 1.44883571892726 0.0509253200737103 no 235 0.0736917330482867 448 6808628 SGTC_2060 5238662 140 µM 1.4466617475867 0.0511822605413023 no 236 0.0739958414948989 441 790130 SGTC_3157 9099274 49.47 µM 1.44358807742571 0.0515472948983766 no 237 0.0744274403184472 412 17217662 SGTC_3011 9081274 71.4286 µM 1.43790501916124 0.0522276744697327 no 238 0.0752305027026863 486 6625322 SGTC_57 miconazole 162.5 nM 1.43666148246767 0.052377498384199 no 239 0.0754071022518029 433 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1915 st067105 30.6 µM 1.43564321428541 0.052500435415767 no 240 0.0755519456768286 471 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2705 st078069 42.8 µM 1.43438833383034 0.0526522539346137 no 241 0.0757307374754192 434 1530061 SGTC_2566 crystal violet carbinol 226 nM 1.43171992631123 0.052976242412891 no 242 0.0761119956801146 424 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_227 fluconazole 33.516 µM 1.43171959423082 0.0529762828310771 no 243 0.0761120432180425 525 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1657 st012939 43.4 µM 1.43072967357446 0.0530968768374019 no 244 0.0762538526784011 409 24207257 SGTC_1815 st051655 58.2 µM 1.43038790993472 0.053138561640681 no 245 0.0763028581339579 419 5984156 SGTC_2482 5981709 142.65 µM 1.42994735745434 0.0531923339632536 no 246 0.0763660642659413 504 877755 SGTC_3339 9145883 14.936 µM 1.42702907410441 0.0535496196864364 no 247 0.076785757216266 425 2030670 SGTC_727 3032-0951 202 µM 1.4233379271038 0.0540042474356448 no 248 0.0773191086599973 423 3652836 SGTC_2896 9052656 71.43 µM 1.41968221330319 0.0544575171406101 no 249 0.0778501093085992 604 6469436 SGTC_1687 st020778 55.3625 µM 1.41884938600169 0.0545611985573828 no 250 0.0779714655168361 635 4259299 SGTC_2067 5224629 34.075 µM 1.41783763226232 0.0546873650593796 no 251 0.0781190872041931 481 2835000 SGTC_72 0744-0168 198.391 µM 1.41708546316228 0.0547813105445142 no 252 0.0782289710693443 460 677577 SGTC_71 0417-1750 47.813 µM 1.41639674173026 0.0548674432954445 no 253 0.0783296886825977 503 6811472 SGTC_1034 k072-0165 12.7 µM 1.41112796722713 0.0555299120616171 no 254 0.0791034424530184 495 5835461 SGTC_714 4296-0578 26.1 µM 1.41036204754615 0.0556267383678457 no 255 0.0792164029374424 350 1589775 SGTC_1626 st003712 1.76 µM 1.40195466107321 0.0566983668976233 no 256 0.0804643930506595 451 24207035 SGTC_2411 st077133 39.94 µM 1.40090968480289 0.0568326911400597 no 257 0.0806205411480724 554 1403142 YNL221C POP1 SGTC_1913 st060213 96.1 µM 1.39997624876313 0.0569528894929027 no 258 0.0807602155053984 515 688959 SGTC_1701 st028638 40.4 µM 1.39902720267633 0.057075303073152 no 259 0.0809024129182676 475 3490878 SGTC_1735 st034310 56.75 µM 1.39678023774914 0.0573659556459203 no 260 0.0812398334177111 486 871153 SGTC_1813 st051246 8.6015 µM 1.39664017108363 0.0573841122364193 no 261 0.0812609019435727 431 5291959 SGTC_799 1310-0557 151 µM 1.3964471866482 0.0574091358684714 no 262 0.0812899369983366 494 5354492 SGTC_225 nsc-122657 1.016 µM 1.39536750177622 0.0575492933243131 no 263 0.0814525230399343 327 275685 SGTC_1411 3909-8223 150 µM 1.39378210613515 0.0577555863539316 no 264 0.0816917066248555 487 X1411 SGTC_2069 5228469 200 µM 1.39246597207205 0.0579272841486986 no 265 0.081890669493759 449 2835210 SGTC_384 k007-0144 5.16 µM 1.39086376310717 0.0581368433813138 no 266 0.0821333715473827 545 6824886 SGTC_1877 wortmannin 25 µM 1.3903818499788 0.058199991091332 no 267 0.082206477474588 547 312145 A covalent inhibitor of PI 3-kinase. SGTC_2098 5376439 882.5 nM 1.39034979714935 0.0582041930591942 no 268 0.0822113416070001 511 2844116 SGTC_3265 9137266 49.47 µM 1.3876618245195 0.0585574218676765 no 269 0.0826200229314631 419 17224265 SGTC_870 0573-2213 57.6 µM 1.3815464634207 0.0593673164117389 no 270 0.0835555009756504 457 3916321 SGTC_594 1487-1584 10.8 µM 1.38106603546563 0.0594313126425923 no 271 0.0836293287700002 499 5013332 SGTC_2352 9027995 87.8 µM 1.38046183929524 0.0595118723873198 no 272 0.0837222457016386 429 2997347 SGTC_3114 9122766 49.47 µM 1.3791486830569 0.0596872555844279 no 273 0.0839244581992776 468 17176985 SGTC_2666 tannic acid 100 µM 1.37784984041249 0.0598611252096913 no 274 0.084124827125049 528 16134267 A thiamine antagonist. SGTC_2215 7188065 200 µM 1.3757704293297 0.0601403113730561 no 275 0.0844463596014249 407 940217 SGTC_1264 0783-0040 158 µM 1.37011845162613 0.0609043101665947 no 276 0.0853249644282793 466 2855798 SGTC_358 0075-0058 9.45 µM 1.3695808063442 0.0609773791504842 no 277 0.0854088972292116 612 1069125 SGTC_784 4579-0127 173 µM 1.36523099067976 0.0615710659709372 no 278 0.0860902304204288 531 1948547 SGTC_207 4185-0010 4.486 µM 1.36295696379967 0.0618832293760589 no 279 0.086448037142364 588 3761753 SGTC_1872 amphotericin b 148 nM 1.3628407422072 0.0618992166275843 no 280 0.086466353847168 506 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_128 0906-2981 13.371 µM 1.36220030551203 0.0619873718782733 no 281 0.0865673397238604 448 6740226 SGTC_2172 5754775 163.918 µM 1.35691774409477 0.0627182507849291 no 282 0.0874036740612678 471 2263357 SGTC_1660 st012960 28.1 µM 1.34388402615644 0.0645502819892522 no 283 0.089492946120259 516 24207266 SGTC_120 rhodamine 6G 52.259 µM 1.34251509023482 0.0647450886417366 no 284 0.0897145204306927 611 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1832 st054113 55 µM 1.33728761716432 0.065493187709224 no 285 0.0905643857026356 473 1251267 SGTC_623 k072-0108 16.9 µM 1.3349409526168 0.0658311892623976 no 286 0.0909478364615002 525 5382803 SGTC_326 k292-0812 17.5 µM 1.33370717239005 0.0660094381043874 no 287 0.0911499216340364 495 3579357 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.33244004002177 0.0661928944755486 no 288 0.091357816094154 564 688664 SGTC_1651 st011928 86.1 µM 1.33197696360227 0.0662600374743585 no 289 0.0914338792369001 520 720198 SGTC_3307 9126885 69.2785 µM 1.33196847343616 0.0662612689841545 no 290 0.0914352742368376 565 24824909 SGTC_1854 st056233 32.9 µM 1.33194290111571 0.0662649783900834 no 291 0.0914394760621322 506 5393174 SGTC_3129 9127257 49.47 µM 1.33168584911062 0.0663022741329981 no 292 0.0914817206024788 443 837894 SGTC_2430 5571206 200 µM 1.33141466699085 0.0663416376364546 no 293 0.0915263029973898 586 1731771 SGTC_3271 9137798 49.47 µM 1.32477759981225 0.0673106946783703 no 294 0.0926224632294122 453 6498326 SGTC_407 eburnamonine 100 µM 1.32449271952657 0.067352532769939 no 295 0.0926697297085524 459 3195 SGTC_2953 9074162 66.49 µM 1.32275515738345 0.0676081499765441 no 296 0.0929584070904056 499 16451992 SGTC_3068 9116768 49.47 µM 1.31625622283762 0.0685708735707186 no 297 0.0940440294059939 491 41904888 SGTC_810 3825-7150 143 µM 1.31446776376564 0.0688376547110888 no 298 0.0943444197128284 552 22330411 YGL099W LSG1 SGTC_2991 9074669 71.4286 µM 1.31054843507341 0.0694250913880084 no 299 0.0950051850995451 613 17333109 SGTC_193 1273-0060 1.558 µM 1.30934168466467 0.069606736732294 no 300 0.0952093177221769 444 2847393 YHR072W ERG7 SGTC_2435 5706476 10.6 µM 1.30625250136234 0.0700734013608562 no 301 0.0957333520338658 575 5725375 SGTC_616 4092-0450 108 µM 1.30605506099624 0.0701033091424891 no 302 0.0957669168779725 570 787165 SGTC_274 sirtinol 40.1 µM 1.30536124600456 0.0702084844178757 no 303 0.095884934025537 533 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.30299475964269 0.0705681326685155 no 304 0.0962882753188236 520 75037 A free radical scavenger. SGTC_466 geldanamycin 89.2 µM 1.30257210450653 0.0706325147259681 no 305 0.0963604432443299 406 5288382 HSP90 inhibitor. SGTC_1717 st033143 58.0435 µM 1.29946772584346 0.0711067816756187 no 306 0.0968917312197984 595 674616 SGTC_145 3737-0113 38.366 µM 1.29568667382082 0.0716877249832768 no 307 0.097541727176273 644 6849351 SGTC_3165 9101544 49.47 µM 1.29535283658051 0.071739192141917 no 308 0.097599269993702 562 5002184 SGTC_397 arbidol 50 µM 1.2923298420623 0.0722065335800992 no 309 0.0981214707994208 574 131410 A RNA synthesis inhibitor. SGTC_1420 4'-methoxyflavone 42 µM 1.29208128893603 0.072245062354396 no 310 0.0981644974828137 540 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1726 st035556 14.5795 µM 1.28668800656732 0.0730849724942864 no 311 0.0991015275187525 600 5919439 SGTC_2860 9025725 38.96 µM 1.28535107732673 0.0732943272926911 no 312 0.0993348144209608 497 40546248 SGTC_1497 4476-2978 41.3 µM 1.2851251337287 0.0733297539262206 no 313 0.0993742799803009 605 1528379 SGTC_2909 7941780 10.49 µM 1.28070520640714 0.0740254098039513 no 314 0.100148615182475 559 1243215 SGTC_228 caffeine 993.056 µM 1.28041399986129 0.074071419470995 no 315 0.100199786430659 501 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2740 felodipine 17.08 µM 1.28006496030844 0.0741265953422919 no 316 0.100261145326037 473 3333 L-type calcium channel blocker SGTC_2249 haloperidol 116.36 µM 1.2767063764547 0.0746591229560896 no 317 0.100852964712769 688 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3253 9135987 49.47 µM 1.27628950328722 0.0747254243629321 no 318 0.100926599678952 512 4182430 SGTC_1213 1315-0166 115 µM 1.276175507941 0.0747435625223835 no 319 0.100946742226834 494 768401 SGTC_1515 3460-0031 42.1 µM 1.27350653178534 0.0751691924802131 no 320 0.101419178116725 487 2876596 SGTC_1442 4112-3290 3 µM 1.27056420397139 0.0756405536284564 no 321 0.101941864179617 592 704353 SGTC_1274 0865-0114 173 µM 1.27042428456832 0.075663024689041 no 322 0.101966768722187 563 870624 SGTC_1325 1431-0015 227 µM 1.26661769963114 0.0762763154246584 no 323 0.102646010270185 544 1103340 SGTC_3260 9137109 49.47 µM 1.26650649336985 0.076294288917005 no 324 0.10266590308062 457 17478346 SGTC_1001 4048-4355 44.4 µM 1.2628355821565 0.0768894034962987 no 325 0.10332413714151 563 21824233 SGTC_1892 st058411 7.36 µM 1.26171351451259 0.0770720113380599 no 326 0.103525946070403 650 3934738 SGTC_762 1165-0429 115 µM 1.25829595933643 0.0776302227680637 no 327 0.104142370970029 581 5967793 SGTC_2564 betulinic acid 100 µM 1.24848872319656 0.0792491445530109 no 328 0.105926067778533 630 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_597 k018-0003 82.8 µM 1.24624936383866 0.0796223644065412 no 329 0.106336430691023 638 6786234 SGTC_2328 6201408 200 µM 1.24619666089146 0.0796311640627064 no 330 0.106346102321883 570 2890418 SGTC_22 0964-0034 14.468 µM 1.24582630710485 0.0796930216992172 no 331 0.10641408465672 610 138402 SGTC_285 1486-1325 46 µM 1.24556510623276 0.0797366701322766 no 332 0.10646204969171 620 22310230 SGTC_2045 5106652 78.05 µM 1.24496726144102 0.0798366421030062 no 333 0.106571892322839 560 673349 SGTC_3071 9117417 49.47 µM 1.23919935294529 0.0808060295653113 no 334 0.107635840074263 489 45595590 YGL055W OLE1 SGTC_410 α-linolenic acid 100 µM 1.23916038916619 0.0808126081255467 no 335 0.107643053258993 608 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_649 1123-0311 367 µM 1.23682343242845 0.0812079147254225 no 336 0.1080763203711 653 693629 YIL048W NEO1 SGTC_897 1000-0139 31.4 µM 1.23615972685927 0.0813204490544317 no 337 0.108199598670274 589 6151020 SGTC_2000 st075254 36.4 µM 1.23611142640299 0.0813286432084864 no 338 0.108208574064806 554 17234175 SGTC_1469 k284-2957 126 µM 1.23337232035883 0.081794351380118 no 339 0.108718443543451 572 23884841 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.23188314867859 0.0820483852743579 no 340 0.108996368538106 620 442882 SGTC_1090 efavirenz 20.7 µM 1.23169731548907 0.0820801277421956 no 341 0.109031086504636 584 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_858 0438-0351 2.77 µM 1.22778790798156 0.0827500462999589 no 342 0.10976329804102 646 2799119 SGTC_1285 0929-0069 65.5 µM 1.22519645647705 0.0831963813768581 no 343 0.110250604641875 601 1206237 SGTC_229 benomyl 22.8748 µM 1.22502902817965 0.0832252802916524 no 344 0.110282141786202 625 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2461 5755302 26.15 µM 1.22465368741665 0.0832900933043617 no 345 0.110352865265018 633 2788904 SGTC_1356 1502-0781 85.8 µM 1.21867815783949 0.0843270514460514 no 346 0.111483185642319 598 567702 SGTC_1479 0549-0158 134 µM 1.21570160378243 0.0848471861449131 no 347 0.112049306505901 684 5440202 SGTC_617 3770-0098 35 µM 1.21182926345384 0.0855274494185174 no 348 0.112788871995744 575 5962639 SGTC_168 3970-0862 530.542 µM 1.20937772388656 0.0859602236589867 no 349 0.113258881386541 783 3135186 SGTC_2828 7998861 71.43 µM 1.20905297123207 0.0860176754667551 no 350 0.113321247646286 512 2988188 SGTC_2340 7987427 183.45 µM 1.20697475529505 0.0863860118569749 no 351 0.113720933105012 602 2239331 SGTC_1422 4031-0024 15.5 µM 1.2061475230638 0.0865329555809439 no 352 0.113880306852307 612 782427 SGTC_3209 9113616 49.47 µM 1.20478138494975 0.0867760357357462 no 353 0.114143854023692 662 16649353 SGTC_3289 9119912 71.43 µM 1.2023600772256 0.0872081177106485 no 354 0.114612024913808 610 17014829 SGTC_2284 7945075 39.21 µM 1.2004367118863 0.0875524852503668 no 355 0.114984889082937 689 1245402 SGTC_3040 9091894 49.47 µM 1.19848796264679 0.0879024315445241 no 356 0.115363553214994 547 25236966 SGTC_212 3807-4682 38.772 µM 1.19642899260091 0.0882733029219662 no 357 0.115764596474137 774 3125501 YBL034C STU1 SGTC_1527 coumarin 137 µM 1.19508136719334 0.0885166742247639 no 358 0.116027620567965 565 323 A hepatotoxic, DNA x-linker. SGTC_1468 k284-1086 134 µM 1.19231521514237 0.089017786542535 no 359 0.116568835387815 679 15996457 SGTC_334 1502-1024 68.5 µM 1.1906687776817 0.0893170536723264 no 360 0.116891819793789 649 3296216 SGTC_3312 9133330 71.43 µM 1.18857277535795 0.089699118763759 no 361 0.117303913143616 673 17617324 SGTC_1066 ketoconazole 628 nM 1.18720387652525 0.0899493005117648 no 362 0.117573606092447 687 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.18239153283516 0.0908329267555551 no 363 0.118525190653372 457 6708630 An antioxidant. SGTC_2669 eugenol 100 µM 1.18239037211925 0.090833140656431 no 364 0.118525420825991 569 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_713 1488-1073 324 µM 1.1792346213531 0.091416076510856 no 365 0.119152381778255 636 3312542 SGTC_2551 apiole 73.87 µM 1.17405294404602 0.0923792526444035 no 366 0.120186909908108 482 10659 A possible DNA adduct former. SGTC_2013 4024628 200 µM 1.17328508645242 0.0925226194238087 no 367 0.120340750398406 580 5230760 SGTC_2010 4012422 159 µM 1.17124179210962 0.0929049248520098 no 368 0.120750800521881 664 952393 SGTC_3270 9137563 49.47 µM 1.16240984591489 0.0945708429501842 no 369 0.122534512891076 580 17015724 SGTC_1712 st032288 53.4 µM 1.16086646179458 0.0948642088146279 no 370 0.122848104856103 794 2883011 SGTC_1117 retinoic acid 1.10837 µM 1.15280149070147 0.0964081077674147 no 371 0.12449593620031 725 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_944 3370-0224 231 µM 1.15063960945117 0.0968250833617048 no 372 0.124940265293372 657 4580514 SGTC_2218 6965428 192.983 µM 1.14578691757857 0.0977658719812083 no 373 0.125941664777941 664 675684 SGTC_1830 st055982 50.3 µM 1.14503769479399 0.0979117185367094 no 374 0.126096771464493 669 455313 An antimicrobial agent. SGTC_1868 st057644 42.7 µM 1.14467366746542 0.0979826390140054 no 375 0.126172181709901 700 688665 SGTC_440 fluspirilene 35.1 µM 1.14390069949715 0.0981333548803523 no 376 0.126332410463615 678 3396 An atypical antipsychotic. SGTC_2089 5281248 129.67 µM 1.14156889161499 0.0985890474357061 no 377 0.12681663043528 683 2737878 SGTC_2525 harmine 47.85 µM 1.13992031707501 0.0989121528385875 no 378 0.127159749890707 609 5280953 A monoamine oxidase inhibitor SGTC_3095 9117207 49.47 µM 1.138829024087 0.0991264619375786 no 379 0.127387236792309 622 17015229 SGTC_519 k048-0011 62.8 µM 1.13820205989772 0.0992497392208843 no 380 0.12751805937525 650 6836379 SGTC_845 0330-0138 4.51 µM 1.13658163428991 0.0995688757723529 no 381 0.127856610632854 671 9039800 SGTC_2059 5238311 157 µM 1.13577716904177 0.0997275903695814 no 382 0.128024917251501 640 703021 SGTC_175 3793-3120 23.7 µM 1.13338106722697 0.100201417200675 no 383 0.128527130636881 625 5322297 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.13221905020303 0.10043179578984 no 384 0.128771176478729 488 4000243 SGTC_1352 1496-0991 99 µM 1.12605961861536 0.101659405266597 no 385 0.130070142502595 688 3000039 SGTC_1151 3909-8316 15.3 µM 1.12449865203948 0.101972242818141 no 386 0.130400771018253 682 800431 SGTC_490 phenamil 164 µM 1.12374433708202 0.102123667950151 no 387 0.130560750713429 574 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3224 9130643 49.47 µM 1.12227243737256 0.102419615727206 no 388 0.130873310802676 654 17644395 SGTC_426 0988-0037 14.6 µM 1.12199785356108 0.102474893921616 no 389 0.130931676267768 748 5383008 SGTC_1340 1486-1359 257 µM 1.12055761900489 0.102765191907855 no 390 0.131238106736403 696 4309068 SGTC_2491 paeonol 100 µM 1.11985801332306 0.102906421986836 no 391 0.131387136428357 668 11092 Increases levels of cortical cytochrome oxidase. SGTC_217 ketoconazole 989 nM 1.11699862926148 0.103485114605333 no 392 0.131997455638043 677 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2829 7992743 58.44 µM 1.11661660695639 0.103562608185169 no 393 0.132079143942358 701 16462845 SGTC_2804 7954240 19.48 µM 1.11440366781684 0.104012333557693 no 394 0.132553025267613 739 828705 SGTC_1859 st055998 20 µM 1.11376442812215 0.104142506511098 no 395 0.132690130579582 720 676301 SGTC_2793 7325131 81.82 µM 1.11308546699612 0.104280897521413 no 396 0.132835862356632 657 4176441 SGTC_928 2764-0428 58.7 µM 1.11172830143625 0.104557924703148 no 397 0.133127493735523 740 662578 SGTC_1279 0874-0590 65.2 µM 1.11128252202153 0.104649034247211 no 398 0.133223380079429 719 3523074 SGTC_457 grayanotoxin iii 135 µM 1.1103988207919 0.104829817336874 no 399 0.133413603067563 743 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_73 0327-0325 16.231 µM 1.11024504548877 0.104861298988961 no 400 0.133446723372476 784 53298 SGTC_1809 st050081 57.6 µM 1.10037410199229 0.106896473168072 no 401 0.135584578781433 705 5036894 SGTC_333 3486-0131 40.1 µM 1.09695221243999 0.107608601467746 no 402 0.136331141312746 738 6744690 SGTC_776 4476-4378 112 µM 1.09693557645275 0.107612071907202 no 403 0.136334777685787 667 2892008 SGTC_1900 st060200 72.8 µM 1.09277434436367 0.1084826827327 no 404 0.137246444331004 717 688945 SGTC_3251 9135047 49.47 µM 1.09200187210533 0.108644855068617 no 405 0.137416139156328 680 17682963 SGTC_686 1319-0111 510 µM 1.09131690663361 0.108788802078536 no 406 0.137566730493269 758 4562600 SGTC_346 4513-0042 7.16 µM 1.08971346425596 0.109126305180963 no 407 0.137919691604843 730 2827372 SGTC_2782 7736369 71.43 µM 1.08940931620969 0.109190409071249 no 408 0.137986712472815 740 2950836 YOL077C BRX1 SGTC_1748 st037455 53.6035 µM 1.08931471448772 0.109210353358522 no 409 0.138007563064898 720 580690 SGTC_1952 st077036 64.1 µM 1.08925931961781 0.109222033126287 no 410 0.138019773309888 703 2937007 SGTC_2048 5246248 200 µM 1.08859483389131 0.109362207014137 no 411 0.138166297975293 684 677046 SGTC_3069 9117009 49.47 µM 1.08781469585914 0.109526942726028 no 412 0.138338460257752 574 41904981 SGTC_2873 9040596 71.43 µM 1.08477747957857 0.110169985394961 no 413 0.13901011109537 711 6463863 SGTC_537 1334-0398 209 µM 1.08456096678411 0.110215928903639 no 414 0.139058075417607 758 5846986 SGTC_1498 4478-3555 97.6 µM 1.08445595466866 0.110238217177176 no 415 0.139081342925933 672 3437919 SGTC_1971 st069429 63.5 µM 1.08017699736639 0.111149154626867 no 416 0.140031684772503 703 1246522 YGL099W LSG1 SGTC_1031 k035-0009 16 µM 1.07965799829418 0.111260008619625 no 417 0.140147252028455 787 5180959 SGTC_1072 oxiconazole 14.9 nM 1.07656112021423 0.111923122085725 no 418 0.140838190814832 756 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3283 9109332 35.8195 µM 1.07579012317921 0.112088648922988 no 419 0.141010565242232 629 17027281 SGTC_3230 9131665 49.47 µM 1.07454090777905 0.112357216735163 no 420 0.14129016020307 604 15943720 SGTC_1524 corynanthine 62.1 µM 1.07435090989551 0.112398104477294 no 421 0.141332717758042 702 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1489 4065-0444 182 µM 1.07257142232977 0.112781568168033 no 422 0.141731726276721 716 2877968 SGTC_3225 9130819 49.47 µM 1.07051954825678 0.113224887118113 no 423 0.142192757359654 741 4547121 SGTC_2055 5235184 200 µM 1.06981034755485 0.113378402650595 no 424 0.142352341853816 726 2836034 SGTC_1232 0279-0259 161 µM 1.06905785361873 0.113541451818057 no 425 0.142521800642173 735 1560000 SGTC_2815 7968870 71.43 µM 1.06629016052499 0.114142589226269 no 426 0.143146248013561 760 2977326 YHR190W ERG9 SGTC_2365 9042475 200 µM 1.06625362422818 0.114150539968273 no 427 0.143154503679888 718 6464479 SGTC_1531 st059297 52.4 µM 1.06480910356809 0.114465201362788 no 428 0.143481162334903 752 7566702 SGTC_3324 9138759 60.749 µM 1.05757418898945 0.116050480872223 no 429 0.145124807505124 737 45595710 SGTC_2518 prenyletin 46.28 µM 1.0547130077043 0.116681689749896 no 430 0.145778300433148 655 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2754 granisetron 64.02 µM 1.05451704086288 0.116725011148904 no 431 0.145823131462123 743 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1306 1185-0270 9.02 µM 1.0526306425678 0.117142610981 no 432 0.146255153754278 795 1548076 SGTC_706 4262-0057 46.9 µM 1.05171152913765 0.117346461988618 no 433 0.146465959909619 716 883298 SGTC_1925 st057770 10.1 µM 1.04804009688267 0.118163258050781 no 434 0.147310066718988 678 5989122 SGTC_2910 7948405 25.97 µM 1.04507531371107 0.118825771492039 no 435 0.147994081252953 704 2971328 SGTC_1727 st034309 9.9045 µM 1.04493204816064 0.118857852079511 no 436 0.148027188262359 838 870305 SGTC_1916 st067606 49.2 µM 1.04418671561266 0.11902484858133 no 437 0.148199505952643 795 19590279 SGTC_645 0845-0943 5.41 µM 1.04393043151691 0.119082308923045 no 438 0.148258788733633 726 1885106 SGTC_34 0469-0683 81.75 µM 1.04341368081668 0.119198226896836 no 439 0.148378370017638 758 3690923 SGTC_1193 1488-0126 41.5 µM 1.04313081251727 0.119261713885778 no 440 0.148443855887559 772 1384710 SGTC_1357 1503-1303 39.5 µM 1.04155430680468 0.119615982138947 no 441 0.148809181327453 800 292895 SGTC_548 1436-0017 110 µM 1.04145725622194 0.11963781532085 no 442 0.148831690584175 844 9677137 SGTC_418 lividomycin a 100 µM 1.04000575586025 0.119964690474102 no 443 0.149168613265887 814 72394 An antibiotic. SGTC_93 0109-0045 59.227 µM 1.03841399840611 0.120323874410339 no 444 0.149538677609709 893 88733 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.03806518747073 0.120402685535735 no 445 0.149619853702821 692 77254 SGTC_3086 9117350 49.47 µM 1.03739700964396 0.120553756649553 no 446 0.149775435698743 709 2679265 SGTC_2286 7945697 125 µM 1.03634595060102 0.120791664997344 no 447 0.150020388068938 736 1245733 SGTC_2433 5607874 27.82 µM 1.03630532918371 0.120800866326885 no 448 0.150029860366554 745 2252428 SGTC_3181 9108277 49.47 µM 1.03596689494301 0.120877545679211 no 449 0.150108793592394 744 17097298 SGTC_1107 amlodipine 47 µM 1.03515527808495 0.121061573995904 no 450 0.150298200275528 752 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1851 st056236 18.9 µM 1.03471543318453 0.12116138799239 no 451 0.15040091320843 790 5393171 SGTC_3238 9133470 49.47 µM 1.03402794852142 0.121317514796296 no 452 0.150561548831906 768 3534688 SGTC_1355 1499-0035 1.68 µM 1.03322340667287 0.121500404707139 no 453 0.150749680754206 736 1548538 SGTC_1242 0402-0103 60.1 µM 1.03277661027204 0.121602054936097 no 454 0.150854226001937 712 432868 SGTC_609 0986-0026 86.3 µM 1.0327515250649 0.121607763819545 no 455 0.150860097084104 781 2848610 SGTC_3054 9094397 49.47 µM 1.03115152399841 0.121972280783557 no 456 0.151234884537378 779 2598354 SGTC_319 1348-1596 45.5 µM 1.0254393104732 0.123279912046689 no 457 0.152577973851096 815 5380505 SGTC_2288 7946289 167.31 µM 1.02334534381482 0.123761711307683 no 458 0.153072295850109 842 1246052 SGTC_3176 9106582 49.47 µM 1.02122743790166 0.124250358100191 no 459 0.153573347828722 637 17018027 SGTC_2026 5148700 152 µM 1.01930809183531 0.124694357082827 no 460 0.154028361804118 775 79838 SGTC_231 b-estradiol 524 µM 1.01861099297542 0.124855889926931 no 461 0.15419384165327 698 450 A steroid. SGTC_2490 carminic acid 95.39 µM 1.01541406798738 0.125598558935252 no 462 0.154954244932707 706 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2616 abietic acid 100 µM 1.01382349925651 0.125969205717091 no 463 0.155333490054543 827 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1615 st002656 86.5 µM 1.01318992006573 0.126117059505934 no 464 0.155484727114479 788 1584458 SGTC_1244 0416-0015 52.5 µM 1.01181773918615 0.126437690033161 no 465 0.155812603315851 775 96201 SGTC_8 0354-0001 70 µM 1.00872625077248 0.127162142258546 no 466 0.15655296932012 890 4993152 SGTC_2345 9052315 157.45 µM 1.00397015801692 0.128282304621689 no 467 0.157696498904635 759 6469265 SGTC_2009 4012297 12.05 µM 1.00291546874192 0.12853163202794 no 468 0.157950824216701 748 45595307 SGTC_3257 9139206 32.98 µM 1.00281936716071 0.128554367045763 no 469 0.157974011307841 772 4910041 SGTC_3277 9138724 49.47 µM 1.00276456802425 0.128567332278997 no 470 0.157987234073795 714 15943418 SGTC_1511 0906-3109 28.5 µM 1.0022165893358 0.128697031522499 no 471 0.158119498636968 874 2882180 SGTC_563 tetrahydrosecaminediol 614 µM 0.999231112101298 0.129405248659931 no 472 0.15884137381854 837 334274 A psychoactive constituent of the cannabis plant. SGTC_2374 9071832 200 µM 0.99875627719598 0.129518137797608 no 473 0.158956385585172 781 17381698 SGTC_179 1273-0063 6.77 µM 0.995559446094626 0.130279941047679 no 474 0.159732123621522 754 3108139 SGTC_2281 7943571 200 µM 0.995115353038714 0.13038601293001 no 475 0.159840082167844 882 1244024 SGTC_1413 3910-0535 34.4 µM 0.991202962600835 0.131323071123543 no 476 0.160793242122706 855 2876951 SGTC_1505 k297-0037 20.6 µM 0.990634899842499 0.131459513712828 no 477 0.160931944879778 806 4089396 SGTC_2300 7976697 71.57 µM 0.988864349853981 0.131885408587606 no 478 0.161364757466621 712 2236109 SGTC_3321 9137793 26.8275 µM 0.988189912960725 0.132047890276869 no 479 0.161529823671001 817 4904192 SGTC_1043 0916-0009 19.3 µM 0.98759044623881 0.132192426390738 no 480 0.161676633552438 931 3101130 SGTC_3107 9121808 49.47 µM 0.985108045517645 0.132792113396689 no 481 0.162285500913497 779 662681 SGTC_2396 5342950 42.78 µM 0.981564614095898 0.133651360795467 no 482 0.163157193780874 823 1886677 SGTC_2981 9013952 38.96 µM 0.976576141002168 0.134867483445996 no 483 0.16438951787194 738 2996344 SGTC_1718 roemerine 11.9335 µM 0.973854224792455 0.135534241550701 no 484 0.165064462412474 836 235224 An aporphine alkaloid with mutagenic activity. SGTC_1663 st014140 55.4 µM 0.971777466073911 0.136044479062974 no 485 0.165580634272179 958 4207120 SGTC_3076 9116187 49.47 µM 0.968806189991835 0.136776773825414 no 486 0.166320948794658 799 27241210 SGTC_500 h-89 112 µM 0.96700282663624 0.137222538849695 no 487 0.166771310306939 892 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_185 k048-0037 25.491 µM 0.964647074853908 0.137806339516556 no 488 0.167360806178812 864 6827589 SGTC_1756 st041558 35.5 µM 0.963631133442739 0.138058631623979 no 489 0.167615446060411 924 3955792 SGTC_248 streptozotocin 5.23457 mM 0.963154755418753 0.138177040577172 no 490 0.167734933372471 875 5300 DNA alkylating agent. SGTC_69 0096-0274 206.684 µM 0.962961048832915 0.138225208258533 no 491 0.167783535425592 900 6741392 SGTC_2220 6782180 200 µM 0.962023778424046 0.138458434521133 no 492 0.16801882981984 754 833803 SGTC_1801 st050089 28.441 µM 0.961450483202928 0.138601222901512 no 493 0.168162855715663 918 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1186 1319-0216 26 µM 0.960754192406483 0.138774780178665 no 494 0.168337887922743 895 4565136 SGTC_3252 9135871 49.47 µM 0.960604633449495 0.138812078511194 no 495 0.168375499039898 831 17682838 SGTC_2475 5812728 15.03 µM 0.959778168343461 0.139018312768519 no 496 0.1685834360918 902 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2744 captopril 92.04 µM 0.959257032633268 0.139148462989201 no 497 0.168714637674688 792 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3297 9117502 71.43 µM 0.959073499471889 0.139194318930363 no 498 0.168760859765042 865 7453720 SGTC_2639 lactacystin 53 µM 0.958571837918818 0.139319712031652 no 499 0.168887242730565 880 3870 A proteasome inhibitor. SGTC_1207 2099-0101 141 µM 0.956851774653626 0.139750234833871 no 500 0.169321037636683 901 5837381 SGTC_3349 9149703 23.001 µM 0.955197282995142 0.140165197946195 no 501 0.16973896978417 842 4910494 SGTC_1791 st048313 56.1 µM 0.954652851995425 0.140301929550791 no 502 0.169876640089582 817 1204976 SGTC_769 0302-0231 76 µM 0.95162364721072 0.14106435573313 no 503 0.170643942182745 926 571869 YER009W NTF2 SGTC_2468 5987765 72.9 µM 0.951158123804921 0.141181772792547 no 504 0.170762056333231 899 26772094 SGTC_214 4373-3496 70 µM 0.95067938234472 0.141302592883225 no 505 0.170883578772497 1019 3779166 SGTC_475 α-linolenic acid 10 µM 0.943305539987202 0.143172385421825 no 506 0.172762321504698 911 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3264 9137442 49.47 µM 0.940712053932307 0.143833973192779 no 507 0.173426220063748 826 17015726 SGTC_3174 9107204 49.47 µM 0.939486053186637 0.144147437824583 no 508 0.173740624782431 842 3938802 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.938819851078918 0.144317965800911 no 509 0.173911622536174 924 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_788 1182-0090 188 µM 0.937460394606722 0.144666368021484 no 510 0.174260893582764 975 5715185 SGTC_257 daunorubicin 18.5 µM 0.936513405942797 0.144909397285062 no 511 0.174504456758918 873 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_198 3454-2873 16.191 µM 0.935252243474955 0.145233480721688 no 512 0.174829160206215 846 710957 SGTC_1462 k081-0014 26.5 µM 0.934451834292303 0.145439416253499 no 513 0.175035435235374 705 3270634 SGTC_2452 5863136 48.41 µM 0.933934631684059 0.145572590592902 no 514 0.175168806627278 866 2184096 SGTC_2808 7946468 45.46 µM 0.93334740231365 0.145723895475111 no 515 0.175320313984215 883 2970879 SGTC_1421 4029-0249 71.4 µM 0.933280969387559 0.14574101916472 no 516 0.175337459155744 968 2894095 SGTC_704 1310-0270 142 µM 0.932603250410842 0.145915784663677 no 517 0.175512427258528 893 5718033 SGTC_1176 0848-0131 83.3 µM 0.932500944990872 0.145942178709252 no 518 0.175538849269506 933 6769040 SGTC_2978 9011784 42.97 µM 0.931305989482193 0.146250706009879 no 519 0.175847652307228 983 2994934 SGTC_3058 9093861 49.47 µM 0.930826641291479 0.146374592623873 no 520 0.175971623158646 847 17217477 SGTC_2102 5377816 72.7585 µM 0.929148468688678 0.146808868092403 no 521 0.176406074420894 913 1379702 SGTC_415 dibenzyl ketone 100 µM 0.928151339003628 0.147067313058725 no 522 0.176664535980142 885 7593 SGTC_169 k015-0017 16.025 µM 0.925312949853611 0.147804661383691 no 523 0.177401572287865 817 1840002 SGTC_1876 myriocin 605 nM 0.92519474286517 0.147835422441333 no 524 0.177432308802626 904 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2418 pentamidine 31.67 µM 0.925191140977873 0.147836359829371 no 525 0.177433245428304 825 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_20 0481-0013 4.944 µM 0.924583649599682 0.147994515870475 no 526 0.177591260607682 905 182045 SGTC_2612 dictamnine 15.46 µM 0.924146336729523 0.148108437233063 no 527 0.177705065445719 835 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_52 0329-0193 875 nM 0.922835642650858 0.148450228553854 no 528 0.178046431631316 849 3739292 SGTC_291 SEC14.278 35.5 µM 0.92212753077798 0.148635103063173 no 529 0.178231029064739 909 1068044 SGTC_1757 st041620 31.8375 µM 0.918910762524506 0.149476877035564 no 530 0.179071125036883 886 5289815 SGTC_614 0462-0418 107 µM 0.916908985837122 0.150002311276223 no 531 0.179595167428373 810 5188303 SGTC_2353 9059630 146.67 µM 0.916744445972924 0.150045555055903 no 532 0.179638284918988 927 4779114 SGTC_923 1900-2434 73.3 µM 0.91426924418411 0.150697081697274 no 533 0.180287693605831 869 5910570 SGTC_3305 9127027 53.8275 µM 0.913393267376357 0.150928108381939 no 534 0.180517872612233 904 41905295 SGTC_442 cape 100 µM 0.912207537184763 0.151241203531057 no 535 0.180829738493938 879 5281787 SGTC_2221 6807166 181.081 µM 0.911963444780549 0.151305710353037 no 536 0.180893980567941 834 674925 SGTC_1137 ixabepilone 100 µM 0.908582233326551 0.152201152599475 no 537 0.181785344151855 904 154225 A novel microtubule stabilizer. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.907857868208109 0.152393442064639 no 538 0.181976659901987 908 688667 SGTC_533 1222-0222 6.71 µM 0.907627762168459 0.152454559586607 no 539 0.182037460717491 937 3982874 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.90758873239326 0.15246492773852 no 540 0.182047774797191 857 5282362 SGTC_534 k292-0788 63.4 µM 0.903918009297289 0.153442136782851 no 541 0.183019439444695 993 4146317 SGTC_1935 st074532 41.6 µM 0.903842384367087 0.153462312947574 no 542 0.183039491822792 977 2829742 SGTC_2638 epoxomicin 18 µM 0.901254696658339 0.15415374738042 no 543 0.183726457589225 944 9915668 A protesome inhibitor. SGTC_1685 st024049 53.0905 µM 0.89998941440031 0.15449258186082 no 544 0.184062942032116 896 1941139 SGTC_2046 4110841 106 µM 0.895975028708344 0.155570865129774 no 545 0.185133050092205 943 44119630 YMR134W ERG29 SGTC_487 nimodipine 119 µM 0.895698535995224 0.155645314698659 no 546 0.18520689626344 817 4497 L-type voltage-gated calcium channels inhibitor SGTC_74 000s-0487 160.283 µM 0.895649611898407 0.155658490649302 no 547 0.185219964903817 974 677548 SGTC_501 nsc-95397 161 µM 0.893315323691573 0.156288002321622 no 548 0.185844167048655 890 262093 SGTC_2879 9041815 71.43 µM 0.891672190281276 0.156732127442654 no 549 0.186284331849748 839 4942971 SGTC_660 4031-1742 102 µM 0.89059560946971 0.157023568137204 no 550 0.186573077739148 916 6738706 SGTC_1926 methyl fluorone black 53.6 µM 0.890135202271015 0.157148313508434 no 551 0.186696646466671 839 72721 Reacts with homocysteine. SGTC_1224 0823-0416 294 µM 0.884562274210988 0.158663442069724 no 552 0.188196380677871 944 3598164 SGTC_1658 st012944 20 µM 0.883056046175034 0.159074583521994 no 553 0.188602995333741 880 24207260 SGTC_3131 9127911 49.47 µM 0.882396125804662 0.159254935715775 no 554 0.188781315026863 875 45595681 SGTC_1938 st074717 56.4 µM 0.881558232255078 0.159484119768331 no 555 0.189007875217378 866 17250979 SGTC_184 1494-0393 24.714 µM 0.881059320680019 0.159620686593284 no 556 0.189142856721223 909 3090647 SGTC_3173 9105693 49.47 µM 0.880645045391755 0.159734144109424 no 557 0.18925498481154 960 17096658 SGTC_458 nppb 133 µM 0.880120843227075 0.159877782889987 no 558 0.189396924440678 911 4549 A chloride channel blocker. SGTC_1787 fluconazole 80 µM 0.880092320798859 0.15988560086013 no 559 0.189404649414249 919 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_190 3970-0790 3.722 µM 0.879855340017283 0.15995056673415 no 560 0.189468840448185 910 2832352 SGTC_42 0133-0086 60.653 µM 0.879536461138944 0.160038011380303 no 561 0.189555236360718 885 162923 Model of phenazepam hydroxylation. SGTC_53 0973-0023 39.979 µM 0.877934881123416 0.160477677783367 no 562 0.18998952925724 939 674768 SGTC_1315 1237-0019 3.69 µM 0.877003377130551 0.160733757262932 no 563 0.190242401881043 973 825140 SGTC_1147 3809-1045 12.3 µM 0.874080810859977 0.161538930031405 no 564 0.191037123408702 910 325925 SGTC_2116 5511452 16.8835 µM 0.872712825628334 0.161916714605632 no 565 0.191409812579427 934 870744 SGTC_3215 9129942 49.47 µM 0.868489842882569 0.163086566900164 no 566 0.192563115159647 900 17682944 SGTC_1330 1469-0054 61.8 µM 0.868387429598115 0.163115005529132 no 567 0.192591137023837 1002 7102664 SGTC_916 4466-0038 42 nM 0.867966457764534 0.163231936927383 no 568 0.192706347627539 1038 5722064 YGL116W CDC20 SGTC_1562 morin hydrate 59.1 µM 0.867497428206021 0.163362281230141 no 569 0.192834760147386 924 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1778 st046819 58.9 µM 0.867254915739162 0.163429702466124 no 570 0.192901176538033 1041 671715 SGTC_1629 st005085 44.9 µM 0.866847058473684 0.163543132196233 no 571 0.193012907072671 931 24207091 SGTC_2441 5730946 39.09 µM 0.866231208761572 0.163714503837778 no 572 0.193181691004617 961 1774275 SGTC_2129 girgensonine 121.053 µM 0.865090597033342 0.164032208045386 no 573 0.193494532624273 988 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1457 k015-0032 57.3 µM 0.864252289391923 0.164265963783247 no 574 0.193724656615056 943 4302660 SGTC_3269 9137823 49.47 µM 0.863367658263435 0.164512870597416 no 575 0.19396767774091 876 17682936 SGTC_2257 7960413 200 µM 0.862782392631585 0.164676354520714 no 576 0.194128560843289 990 2974689 YIL048W NEO1 SGTC_1798 st045719 60.953 µM 0.861706014841632 0.164977296918973 no 577 0.194424657429533 913 3980186 SGTC_2180 6301957 200 µM 0.861494938730475 0.165036353021051 no 578 0.194482753763333 986 845462 SGTC_3246 9135460 32.98 µM 0.861286446376509 0.165094699659524 no 579 0.194540149318985 890 41446951 SGTC_2 0422-0095 29 µM 0.860685188890493 0.165263036493918 no 580 0.194705726335956 850 6790840 SGTC_857 0438-0306 1.35 µM 0.860354094468684 0.165355781936547 no 581 0.194796941215413 966 4686136 SGTC_2954 9074818 52.69 µM 0.860170848910938 0.165407126754305 no 582 0.194847435633908 925 16648742 SGTC_2746 daunorubicin 9.88 µM 0.858111028116107 0.165984991455614 no 583 0.195415579180453 842 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1962 st076595 64.5 µM 0.856507306053298 0.166435803812729 no 584 0.195858616686521 968 279619 SGTC_122 0236-0016 402.397 µM 0.855629462520121 0.16668290342716 no 585 0.196101383966394 1047 6808838 SGTC_658 3253-0951 102 µM 0.853774276603326 0.167205888456182 no 586 0.196615034932199 1018 1184878 SGTC_2379 9035213 200 µM 0.852815310448335 0.167476639471801 no 587 0.196880866056557 1013 646551 SGTC_2259 7964009 200 µM 0.852239381392733 0.167639380870708 no 588 0.197040621554886 908 313134 SGTC_1837 st055472 66.5 µM 0.851098589855822 0.167962037142322 no 589 0.197357294351175 971 676091 SGTC_2335 9018011 154.17 µM 0.850312311362556 0.168184657100345 no 590 0.19757573680806 1001 6458208 SGTC_561 1550-0330 72.9 µM 0.849729336990608 0.168349837818159 no 591 0.1977377920033 933 6812934 SGTC_3199 9111318 49.47 µM 0.848712489303441 0.16863820238894 no 592 0.198020647454258 939 8548020 SGTC_1699 st031318 29.054 µM 0.848432894606203 0.168717547369231 no 593 0.198098464826805 1011 5340658 SGTC_2139 5578692 56.4705 µM 0.848334835935368 0.168745380700858 no 594 0.198125761091181 943 650991 YMR113W FOL3 SGTC_1794 st048918 76.9 µM 0.845673586868388 0.169501885931248 no 595 0.198867430929236 912 672303 SGTC_2739 tacrine 100.86 µM 0.845301857170327 0.169607729360265 no 596 0.198971162207583 961 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1845 st056753 3.01 µM 0.845217575700056 0.169631732907025 no 597 0.198994685509633 992 5375839 SGTC_2870 9038528 12.99 µM 0.84229134582932 0.170466480638101 no 598 0.199812446992956 886 6463316 SGTC_2741 miltefosine 3.04 µM 0.842150669439561 0.170506676694271 no 599 0.199851811142743 890 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1688 st021091 57.6 µM 0.836758017993976 0.172052116055024 no 600 0.201364299925809 1017 3656366 SGTC_1217 1183-1422 255 µM 0.836337091698847 0.17217312120473 no 601 0.201482646016804 1040 2849664 SGTC_2213 7173844 200 µM 0.83530005653799 0.17247147298367 no 602 0.201774392793474 1015 892728 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.833968517260641 0.172855035859935 no 603 0.202149362466714 936 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_922 1866-0035 480 µM 0.833490747827757 0.172992794423167 no 604 0.20228400685902 1058 3156169 SGTC_2787 5284540 71.43 µM 0.833331629052538 0.173038689762109 no 605 0.20232886142098 968 736958 SGTC_2891 9063876 19.48 µM 0.831965606854578 0.17343301673078 no 606 0.202714178999214 944 6472478 SGTC_1878 temozolomide 1 mM 0.831454783931079 0.173580621814056 no 607 0.202858380775023 985 5394 DNA alkylating agent. SGTC_766 1391-0721 126 µM 0.830801716909041 0.173769445499894 no 608 0.203042826295536 1004 1020919 YIL115C NUP159 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.82959264427899 0.174119373864447 no 609 0.203384568509269 1059 16486 A toxic proline analog. SGTC_1172 0370-0043 85 µM 0.82812868869798 0.174543669199646 no 610 0.203798811936638 995 376585 SGTC_1312 1218-2183 165 µM 0.8267346116269 0.174948321601731 no 611 0.204193749526048 1035 6744073 SGTC_2126 5251174 33.877 µM 0.824937557182877 0.175470821915768 no 612 0.204703521231103 1074 790722 SGTC_987 1497-1013 404 µM 0.822872709035924 0.176072404127321 no 613 0.205290191853265 1031 1676435 SGTC_2246 7293507 91.5585 µM 0.818888949269331 0.177236735348558 no 614 0.206424887680783 1057 887656 SGTC_825 1988-2224 89.6 µM 0.814513378555024 0.178521170688588 no 615 0.20767545557794 990 1180859 SGTC_1553 gossypol 38.6 µM 0.813389335411034 0.178852074286513 no 616 0.207997435908129 956 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2226 7298446 200 µM 0.811319813399805 0.179462323480734 no 617 0.208591017319314 1006 3283010 SGTC_1643 st009866 20.2 µM 0.810136902382018 0.17981172092261 no 618 0.208930748566434 1043 3156273 YOR207C RET1 SGTC_3024 9090631 49.47 µM 0.808091327828231 0.180416931617338 no 619 0.209519004765305 1010 25236383 SGTC_1401 3807-4679 7.6 µM 0.807051824996403 0.18072497162816 no 620 0.209818312829237 998 3291456 SGTC_2539 epi(13)torulosol 80 µM 0.80694927605156 0.180755378224454 no 621 0.209847853758005 1021 6708597 SGTC_909 3448-9333 149 µM 0.805269269133766 0.181253970523218 no 622 0.210332155688743 969 3344074 SGTC_2214 7179297 48.276 µM 0.804387982907843 0.181515862649025 no 623 0.210586469595531 1046 769744 SGTC_156 3474-0145 5.642 µM 0.804100600435242 0.181601315381263 no 624 0.21066943892466 1020 2265471 SGTC_637 1181-0519 7.26 µM 0.803080068828458 0.181904972263013 no 625 0.210964228468815 1101 6252091 YGR060W ERG25 SGTC_2689 tacrolimus 100 µM 0.802551059710426 0.182062502627735 no 626 0.211117132536416 1011 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1327 1436-0082 2.18 µM 0.802350148976126 0.182122352937567 no 627 0.211175220511982 1006 15992205 SGTC_41 0478-0632 82.643 µM 0.799800642177554 0.182882906336658 no 628 0.211913155465746 1093 3750424 SGTC_698 k064-0052 127 µM 0.799269926751101 0.183041475056295 no 629 0.212066956392774 1061 5088751 SGTC_780 0109-0199 192 µM 0.798259984144965 0.183343465535705 no 630 0.212359817220946 1101 610414 SGTC_2936 9038235 15.59 µM 0.796856969294604 0.18376350669229 no 631 0.212767052190578 1069 4749415 SGTC_96 0929-0093 37.281 µM 0.796852932903352 0.183764715990168 no 632 0.212768224438959 988 6991579 SGTC_2768 sulfasalazine 50.2 µM 0.796563787841305 0.183851356393693 no 633 0.212852207730326 1068 5384001 An antioxidant and salicylic acid derivative. SGTC_2819 7996655 46.38 µM 0.794965229824522 0.184330812739569 no 634 0.213316864086475 936 6456960 SGTC_1045 1348-1485 165 µM 0.794777267030684 0.184387239590456 no 635 0.213371538473409 1140 6810614 SGTC_1257 0669-0121 16 µM 0.794465815888263 0.184480761572041 no 636 0.213462150980238 1125 4307855 SGTC_659 k018-0002 107 µM 0.792707407604286 0.185009326565497 no 637 0.213974156731881 1062 6797879 YHR007C ERG11 SGTC_973 1325-0077 65.9 µM 0.792653430933769 0.185025566438368 no 638 0.21398988472725 1094 2835149 SGTC_1630 st005209 31.3 µM 0.79254464199274 0.18505830028094 no 639 0.214021586244249 1103 3367314 SGTC_1648 st011736 69.8 µM 0.79195653582661 0.185235319660153 no 640 0.214193009975141 1041 2855514 SGTC_938 3126-1755 342 µM 0.78972522338283 0.185907898365987 no 641 0.214844128682533 1090 1777771 SGTC_1715 st032160 10.2275 µM 0.789293902370414 0.18603808478341 no 642 0.21497012484 1001 5289825 SGTC_64 000l-0018 272.079 µM 0.789193063324665 0.186068529368033 no 643 0.214999587817298 1062 6811119 SGTC_368 fentichlor 4.58 µM 0.788677229888192 0.186224314316369 no 644 0.215150339808728 999 7329 A pesticide. SGTC_151 3013-0144 2.285 µM 0.786949943313919 0.18674655396492 no 645 0.215655584726817 1030 906558 YHR107C CDC12 SGTC_790 1575-0012 79.1 µM 0.784983647680219 0.187342159444824 no 646 0.21623157810591 1101 378741 YLR208W SEC13 SGTC_2583 asiatic acid 100 µM 0.783191369933789 0.187886075451632 no 647 0.216757370989866 1072 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_890 0929-0006 47.2 µM 0.782300586020784 0.188156770731028 no 648 0.217018971271757 1040 1378169 SGTC_1739 st037196 92.5 µM 0.781967156207076 0.188258156703414 no 649 0.217116937926043 1096 612214 SGTC_2403 6032726 181.2 µM 0.781484531698647 0.188404967983684 no 650 0.217258785456493 1047 2881040 SGTC_1696 st025591 34.7925 µM 0.78050811330148 0.188702204077763 no 651 0.217545926921455 1088 2787147 SGTC_1929 genistein trimethyl ether 50.5 µM 0.780334032369438 0.188755227213447 no 652 0.217597142986775 1106 136420 SGTC_2478 5763493 32.33 µM 0.778948963479844 0.189177431063284 no 653 0.218004889691543 1059 1365576 YLR208W SEC13 SGTC_1793 st048256 72.231 µM 0.777369592320253 0.189659572115698 no 654 0.218470373606342 1039 672022 SGTC_2834 9001755 58.44 µM 0.77713455192566 0.189731388410579 no 655 0.218539695339397 970 2989575 SGTC_299 1273-0059 1.44 µM 0.777121297574028 0.189735438759041 no 656 0.218543604894115 1039 2848077 SGTC_1062 mesoridazine 14.2 µM 0.776457417020614 0.189938379604176 no 657 0.218739477181243 1073 4078 A neuroleptic. SGTC_2296 7971656 126.45 µM 0.775670377708253 0.190179141498967 no 658 0.218971817240117 1074 666570 SGTC_1742 st038235 28.8875 µM 0.773414407499415 0.190870300039871 no 659 0.219638583020376 1032 564103 YBR002C RER2 SGTC_3294 9122953 26.2835 µM 0.772788427700999 0.191062353412288 no 660 0.219823801603673 1124 16459826 SGTC_886 0866-0150 153 µM 0.772427740218316 0.191173067722844 no 661 0.219930564635576 1127 271463 SGTC_2886 9058944 51.95 µM 0.771592553269158 0.191429582286279 no 662 0.220177893086156 951 4949929 SGTC_3303 9125618 40.5795 µM 0.77133248007167 0.191509502730369 no 663 0.22025494253269 1104 22695467 SGTC_163 TUB2.036 7.546 µM 0.770995747364194 0.191613010990429 no 664 0.220354726136814 1141 15992207 YJR013W GPI14 SGTC_1578 josamycin 24.2 µM 0.769940766995341 0.191937523177656 no 665 0.220667514941787 1035 5282165 A P450 substrate. SGTC_605 1315-0399 119 µM 0.769148698254358 0.192181384643404 no 666 0.220902520717325 1113 24020461 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.768463037098159 0.192392638414099 no 667 0.22110607114825 1073 616764 SGTC_1010 4112-3296 15.2 µM 0.76783773882544 0.192585417985373 no 668 0.221291795338131 1132 704384 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.767535905987151 0.192678515339862 no 669 0.221381476728751 1120 94937 An inhibitor of serotonin biosynthesis. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.767041827865064 0.192830968193567 no 670 0.221528323402471 1160 5024745 SGTC_1800 st050079 29.0735 µM 0.767005840196301 0.19284207543492 no 671 0.221539021597424 1115 3645560 SGTC_507 nimesulide 162 µM 0.766522959441915 0.192991149650549 no 672 0.221682598008984 1081 4495 A COX2 inhibitor. SGTC_806 3966-4455 5.86 µM 0.766172316486672 0.193099443705113 no 673 0.221786889064159 982 714982 SGTC_1612 st002233 45.4 µM 0.765377809124607 0.193344959956107 no 674 0.222023301522578 1128 1035021 SGTC_734 2023-0417 80 µM 0.76500534503752 0.193460123226948 no 675 0.222134180910168 1054 3935732 SGTC_2149 5554786 194.827 µM 0.762968999708673 0.194090486341561 no 676 0.222740942029077 1140 745063 YPR165W RHO1 SGTC_2786 7743617 45.45 µM 0.762834913249262 0.194132037484692 no 677 0.222780928316474 1017 583674 SGTC_1634 st006576 41 µM 0.759884902190729 0.195047566837512 no 678 0.223661693501263 1097 3915356 SGTC_2919 7978188 46.38 µM 0.759273035353778 0.195237786489059 no 679 0.223844622122241 1103 2980291 SGTC_1683 st010134 710 nM 0.759157249758888 0.195273795065999 no 680 0.22387924787869 1145 3818134 SGTC_1364 1653-0028 37.6 µM 0.75807100807497 0.195611805728438 no 681 0.224204237344335 1059 5718652 SGTC_3194 9111903 49.47 µM 0.756027455663194 0.196248669073649 no 682 0.224816367280211 1095 17087251 SGTC_485 niflumic acid 177 µM 0.755915891713724 0.196283473596579 no 683 0.224849812632944 1070 4488 A COX2 inhibitor. SGTC_2376 9072922 81.32 µM 0.75550333105488 0.196412212343268 no 684 0.224973517200366 1144 17087968 SGTC_2393 9031399 185.94 µM 0.751585349030727 0.197637359973924 no 685 0.226150228349861 1124 1526623 YDL150W RPC53 SGTC_1123 mangostin 811.285 nM 0.751115630604151 0.197784549733449 no 686 0.226291534823897 1035 5281650 An antioxidant. SGTC_206 4546-0025 72.014 µM 0.749473880490922 0.198299524430178 no 687 0.226785817909901 1146 6620745 YIL048W NEO1 SGTC_1736 st036774 51 µM 0.748901242464207 0.198479336408408 no 688 0.226958365703205 1150 1272247 SGTC_2065 5221596 34.26 µM 0.746063994968985 0.199371700292347 no 689 0.227814378953645 1084 788581 SGTC_221 trifluoperazine 10.304 µM 0.744276523137901 0.199935129659833 no 690 0.228354600629255 1181 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2101 5377231 179.231 µM 0.740613238300774 0.201092822225226 no 691 0.229463989455608 1119 2844213 SGTC_3055 9094636 49.47 µM 0.740351734084619 0.201175617766172 no 692 0.229543298701498 1156 25236176 SGTC_1220 1838-0075 193 µM 0.739458742630642 0.201458504198775 no 693 0.229814241732669 1088 5529645 SGTC_2489 cantharidin 73.42 µM 0.73912326714014 0.201564839420695 no 694 0.229916074789003 1145 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_535 2293-4129 48.2 µM 0.737926119299462 0.201944571799521 no 695 0.230279672943145 1172 396118 YIL048W NEO1 SGTC_855 0428-0020 25 µM 0.737413517509126 0.202107298690695 no 696 0.23043545880563 1085 6812414 SGTC_586 0957-0265 8.15 µM 0.736697981910485 0.202334578654627 no 697 0.230653017183657 1050 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2165 5727197 32.143 µM 0.736254030945339 0.202475670335738 no 698 0.230788058006815 1224 1361712 SGTC_2625 euphol 100 µM 0.735875979364408 0.202595864950584 no 699 0.230903088386191 1132 6708538 A triterpene alcohol. SGTC_1142 3253-1408 9.78 µM 0.735323976182793 0.202771440885924 no 700 0.23107110478849 1130 256655 SGTC_3213 9129884 49.47 µM 0.733449665768965 0.203368281821249 no 701 0.231642108374245 1105 17190742 SGTC_665 3914-0008 307 µM 0.731942817066199 0.203848870319586 no 702 0.232101735391793 1135 1069549 SGTC_2657 nystatin 74.44 µM 0.731345785425126 0.204039472356514 no 703 0.232283985484621 1172 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_662 k832-1615 104 µM 0.728631955563608 0.204907198379521 no 704 0.233113412896203 1119 5878478 SGTC_1284 0929-0043 16 µM 0.728053308883084 0.205092499553471 no 705 0.233290477034993 1114 1239883 SGTC_3045 9092950 49.47 µM 0.727785124608315 0.20517841449969 no 706 0.233372565918792 1165 44120432 SGTC_1109 tnp00067 928.257 nM 0.727277090861256 0.205341225730669 no 707 0.233528114574631 1133 676295 SGTC_511 blebbistatin 171 µM 0.727078424616213 0.205404913815645 no 708 0.233588957404309 1154 3476986 A myosin inhibitor. SGTC_2670 beta-carotene 100 µM 0.726920992719431 0.205455391394532 no 709 0.233637178188794 1107 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1939 st074455 53.6 µM 0.726651588301388 0.205541787944178 no 710 0.233719708527921 1150 1644229 SGTC_3133 9127736 49.47 µM 0.725519537736295 0.205905066160553 no 711 0.234066681624585 1153 27243420 SGTC_783 0848-0141 92.7 µM 0.722127162565796 0.206995967344967 no 712 0.235108149809333 1137 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_278 4092-0821 23.9 µM 0.72153463395785 0.20718685964262 no 713 0.235290319877683 1156 877900 SGTC_1190 1486-1332 13 µM 0.720795372960441 0.2074251699924 no 714 0.235517711334086 1150 4150046 SGTC_1988 st071872 53.4 µM 0.719725875823655 0.207770222863996 no 715 0.235846895579905 1164 16414116 SGTC_2644 guaiazulene 100 µM 0.719308190436477 0.207905073102499 no 716 0.235975525258793 1177 3515 A coloring agent. SGTC_2640 pentamidine 10.38 µM 0.719137335963618 0.207960248568361 no 717 0.236028152450191 1182 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_417 st075190 100 µM 0.716949998730204 0.20866738719092 no 718 0.23670247477546 1166 222757 SGTC_1085 doxorubicin 7.67 µM 0.716745506378133 0.208733569363978 no 719 0.23676557073232 1195 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2166 5933061 31.504 µM 0.71482941673992 0.209354295897302 no 720 0.237357227858655 1356 2877375 SGTC_943 3253-1379 105 µM 0.714561634991398 0.209441131526693 no 721 0.23743997909009 1140 668464 SGTC_1129 3453-1384 223 µM 0.714036365574625 0.209611526186731 no 722 0.237602346419844 1206 1084452 SGTC_3338 9144300 39.5675 µM 0.713866941771587 0.209666503770367 no 723 0.237654730423473 1152 4901274 SGTC_3155 9099265 49.47 µM 0.713695576113165 0.209722120106125 no 724 0.237707721273107 1105 25236499 SGTC_51 1013-0126 23.419 µM 0.713368480405054 0.209828302353907 no 725 0.237808886015453 1200 1627850 SGTC_1903 st060211 78.3 µM 0.712686258622942 0.210049867770834 no 726 0.238019960745395 1188 688960 SGTC_1322 1348-1070 12 µM 0.711659432326691 0.210383609540179 no 727 0.23833784725238 1157 6758089 SGTC_3099 9120367 49.47 µM 0.711536549198393 0.210423570182401 no 728 0.238375905177467 1218 24824940 SGTC_2620 irigenin 100 µM 0.706800089371398 0.211967223063223 no 729 0.239845359517064 1201 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3207 9114163 49.47 µM 0.705960235025346 0.212241628505642 no 730 0.240106433405455 1220 849233 SGTC_325 2810-4341 181 µM 0.705434421564061 0.212413533076289 no 731 0.240269964575547 1191 774970 SGTC_2718 lomofungin 53.02 µM 0.705432042686824 0.212414310989136 no 732 0.240270704558649 1203 5351222 A RNA synthesis inhibitor. SGTC_1187 1391-0724 117 µM 0.705261750351709 0.212470002338155 no 733 0.240323679602 1213 6997986 SGTC_1438 4092-1045 4 µM 0.701999982031114 0.213538356194866 no 734 0.241339587326808 1185 1351342 SGTC_2093 5331342 194.4 µM 0.69915707639766 0.214472064560763 no 735 0.242226936069478 1188 33839 SGTC_1846 st056244 14.8 µM 0.699094651204906 0.214492593748678 no 736 0.24224644050503 1191 5393182 SGTC_1508 1080-0625 72.9 µM 0.697881586579225 0.214891749695496 no 737 0.242625625346428 1138 767111 SGTC_3025 9087895 49.47 µM 0.697769530694846 0.214928643166091 no 738 0.242660668453206 1208 17173641 SGTC_1265 0819-1001 68.8 µM 0.696986138013304 0.215186671450867 no 739 0.242905734465211 1203 3106768 SGTC_2545 solidagenone 89.61 µM 0.696767688527053 0.215258654829129 no 740 0.242974095127965 1027 6708572 An anti ulcer agent SGTC_2471 5466956 24.79 µM 0.696230136939055 0.215435848083359 no 741 0.243142358564512 1143 724419 SGTC_1611 st001856 99.4 µM 0.695702212954269 0.215609950113601 no 742 0.243307669690036 1168 647478 SGTC_918 glabranin 770.725 nM 0.694922690391628 0.215867174991928 no 743 0.24355187599595 1213 124049 Also referred to as licorice root. SGTC_975 1335-0046 28.5 µM 0.694761193940451 0.215920487410192 no 744 0.243602485630901 1189 16486740 SGTC_2447 5741742 33.78 µM 0.691078983411818 0.217138109190821 no 745 0.244757953458408 1229 1776504 SGTC_512 prima-1 270 µM 0.690398190979139 0.217363665223707 no 746 0.244971907026648 1197 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1752 st044819 83.042 µM 0.689656095002591 0.217609686019285 no 747 0.24520524112126 1168 441209 YML126C ERG13 SGTC_3328 9140624 29.0385 µM 0.688459312325497 0.218006783594647 no 748 0.245581792050654 1213 4904392 SGTC_2346 9031566 143.75 µM 0.68783548807383 0.218213936656724 no 749 0.245778192702873 1176 4771086 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.686718690296524 0.218585074389007 no 750 0.246130008340795 1207 688798 SGTC_2380 9035439 200 µM 0.686067066819217 0.218801791717821 no 751 0.246335408643637 1277 6462575 SGTC_1888 azatryptophan 97.5 µM 0.685658124586936 0.218937861091555 no 752 0.24646435953151 1172 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1463 k081-0032 34.1 µM 0.684827624509544 0.219214347246423 no 753 0.246726350642387 1074 977755 SGTC_1216 1165-0504 9.65 µM 0.684156068988281 0.21943806502664 no 754 0.246938309800916 1213 6304004 SGTC_724 3910-0327 137 µM 0.681029520396541 0.220481349137582 no 755 0.247926405719248 1221 2885483 SGTC_126 0417-1624 672.48 µM 0.680176185500814 0.220766587669671 no 756 0.248196454715065 1314 41912 YDL195W SEC31 SGTC_2207 7258803 200 µM 0.678840739717001 0.22121340204169 no 757 0.248619388650977 1183 3666799 SGTC_835 0312-0010 67.2 µM 0.678313122080101 0.221390075181185 no 758 0.248786590203126 1193 1626196 SGTC_111 0083-0039 52.457 µM 0.67499146477863 0.222504185649495 no 759 0.249840593839331 1150 759313 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.674960794088929 0.222514487718944 no 760 0.249850337067966 1251 1273210 SGTC_1822 st052468 42 µM 0.674490759476595 0.222672403067602 no 761 0.249999679274407 1219 2873678 SGTC_362 0310-0100 9.03 µM 0.674456147302794 0.222684034083742 no 762 0.25001067833327 1256 790235 SGTC_2763 lisinopril 49.32 µM 0.671894911098531 0.223545667919449 no 763 0.250825300155691 1206 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2492 derrusnin 100 µM 0.671381486874677 0.22371861851745 no 764 0.250988767783572 1179 1715307 Part of coumarin class of compounds. SGTC_1741 st038134 10.228 µM 0.671000115780493 0.223847135305679 no 765 0.251110227884223 1290 1272587 SGTC_553 k007-0256 45.7 µM 0.666595357330949 0.225334515688141 no 766 0.252515317713449 1282 6287000 SGTC_1529 apigenin 74 µM 0.66649272601386 0.225369238388045 no 767 0.252548105763056 1311 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3003 9075612 71.4286 µM 0.666144137139381 0.225487197198548 no 768 0.252659487631739 1239 6501993 SGTC_2493 resveratrol 26.09 µM 0.665861044967873 0.225583018322531 no 769 0.252749960886387 1180 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2748 diazoxide 86.69 µM 0.665199334989563 0.225807083973208 no 770 0.252961502894876 1197 3019 A potassium channel activatior. SGTC_1545 lovastatin 49.4 µM 0.662456193636484 0.226737297141713 no 771 0.253839450277348 1292 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2255 7941087 197.44 µM 0.661969125709623 0.226902690110146 no 772 0.253995504300802 1272 935561 SGTC_829 1635-0120 117 µM 0.661529970172968 0.22705187185509 no 773 0.254136250586614 1255 285054 SGTC_2831 7999036 19.48 µM 0.660846140194383 0.227284279911461 no 774 0.254355494737063 1263 2988270 SGTC_675 1309-0189 238 µM 0.659587159383415 0.227712510459267 no 775 0.254759398326571 1230 4246530 SGTC_2515 chrysin 20.77 µM 0.658668126774431 0.228025397361867 no 776 0.255054452337301 1247 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2852 9023854 51.95 µM 0.657600627375736 0.228389133512483 no 777 0.255397395659652 1312 19798528 SGTC_3062 9077494 49.47 µM 0.656731684985955 0.228685454574755 no 778 0.255676728654131 1246 16459633 SGTC_2948 9070189 9.45 µM 0.654648781194641 0.22939663103029 no 779 0.256346954524478 1189 6473636 YDL196W YDL196W SGTC_1666 st014829 29 µM 0.653135106689579 0.229914229432432 no 780 0.256834590656097 1278 3858230 SGTC_2869 9037858 32.47 µM 0.652339111236282 0.230186680779693 no 781 0.257091217242939 1224 27187042 SGTC_1118 chelidonine 707.474 nM 0.650672556698956 0.230757689390987 no 782 0.257628941070787 1284 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.650525187634521 0.23080822023735 no 783 0.257676518672718 1257 4174840 SGTC_856 0433-0016 11.3 µM 0.650258632298445 0.230899634129922 no 784 0.257762586743934 1265 3911780 SGTC_2229 7354935 190 µM 0.64842282324169 0.231529764930946 no 785 0.258355756284566 1218 318112 SGTC_777 1315-0167 517 µM 0.647939814459443 0.231695714041266 no 786 0.258511939033056 1236 4221767 SGTC_11 0438-0307 1.3 µM 0.64648888919575 0.232194612157985 no 787 0.258981395208857 1275 4011476 SGTC_2664 lyso-paf C-16 73.48 µM 0.645149277745351 0.232655765519627 no 788 0.259415226256616 1279 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_949 1165-0505 146 µM 0.644576524707297 0.23285308763964 no 789 0.259600825919459 1280 6244267 SGTC_624 k048-0052 28 µM 0.642389326544398 0.233607465435714 no 790 0.26031021406968 1242 6835531 SGTC_1287 0971-0001 34.6 µM 0.640365898828869 0.234306562886916 no 791 0.260967373719081 1289 4665869 SGTC_1427 4048-4900 550 nM 0.638704478722523 0.234881450813857 no 792 0.261507599287355 1289 24132586 SGTC_3179 9107801 49.47 µM 0.634492234645544 0.236342467573738 no 793 0.262879816498363 1277 4818259 SGTC_2402 5553605 200 µM 0.632685807909133 0.236970556278839 no 794 0.263469419749908 1342 6758546 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.630986647862583 0.237562185098622 no 795 0.264024627408152 1177 88881 An O-methylated flavonoid and antioxidant. SGTC_549 1661-1316 519 µM 0.629642801421196 0.238030671126288 no 796 0.264464156696486 1322 2857282 SGTC_978 1416-0512 87.4 µM 0.62959194793288 0.238048409391696 no 797 0.264480796558913 1327 6814003 SGTC_3326 9140064 16.379 µM 0.629310058263856 0.238146748798537 no 798 0.264573043851324 1269 1868434 SGTC_3188 9110789 49.47 µM 0.628158737738996 0.238548626967427 no 799 0.264949978869441 1329 849217 SGTC_2800 7887935 81.82 µM 0.627513200214174 0.238774119621607 no 800 0.265161443086113 1309 2961002 SGTC_977 1348-1378 135 µM 0.627369135284911 0.238824458839459 no 801 0.265208647356008 1273 X977 SGTC_316 k060-0003 58.6 µM 0.62635134977972 0.239180259122792 no 802 0.265542256150159 1326 6152314 SGTC_117 lucigenin 22.078 µM 0.625508724789903 0.239475045347516 no 803 0.265818611973419 1270 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1258 0671-0043 57.1 µM 0.62361178538366 0.240139401216489 no 804 0.266441284441279 1282 4298767 SGTC_2037 5169046 200 µM 0.623506267567169 0.240176385680645 no 805 0.266475942433408 1328 5718022 SGTC_2752 diclazuril 33.15 µM 0.620144188051998 0.241356433320401 no 806 0.267581431196609 1344 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2895 9054447 58.44 µM 0.619579869133471 0.241554810446249 no 807 0.267767211821479 1320 2697450 SGTC_1923 st058458 19.1 µM 0.618386850715225 0.241974487933264 no 808 0.268160181749872 1409 3534982 SGTC_3019 9081971 49.47 µM 0.61765482763256 0.242232193115789 no 809 0.268401447402947 1372 16451803 SGTC_1754 st042065 16.137 µM 0.617052908906937 0.242444207093756 no 810 0.268599914035305 1262 1126236 YIL048W NEO1 SGTC_1486 3970-0793 4.53 µM 0.616912633055423 0.2424936309303 no 811 0.268646176847609 1334 2844330 SGTC_188 3229-0966 278.469 µM 0.616627311529792 0.24259417600706 no 812 0.268740287907194 1421 5722370 SGTC_954 1189-0853 2.85 µM 0.615424332419204 0.243018344580047 no 813 0.269137263132553 1297 2828194 SGTC_2849 9019321 12.99 µM 0.614574251759909 0.243318323426046 no 814 0.26941796148719 1316 16489627 SGTC_2839 9003951 25.97 µM 0.614459352918515 0.243358884598322 no 815 0.269455912573093 1323 2990634 SGTC_3275 9138069 49.47 µM 0.613541588056953 0.243683001736486 no 816 0.269759146447884 1344 17617007 SGTC_2504 purpurogallin 52.29 µM 0.612145648733091 0.244176437124152 no 817 0.270220698844927 1295 5281571 An antioxidant. SGTC_2274 7947094 46.08 µM 0.611037908189319 0.244568383324238 no 818 0.270587242217395 1306 2971028 SGTC_1023 4482-3888 16 µM 0.609662234444562 0.245055602310407 no 819 0.271042788217073 1366 3303168 SGTC_2930 9013230 14.89 µM 0.609085804008401 0.245259910372468 no 820 0.271233783317796 1332 2995857 SGTC_3332 9141069 11.198 µM 0.608341462542543 0.245523867668008 no 821 0.271480513459986 1297 17332883 SGTC_2303 7774051 200 µM 0.607973869057875 0.245654279411592 no 822 0.27160240251628 1376 2953184 SGTC_1603 st002045 67.8 µM 0.607366149313277 0.245869962703953 no 823 0.271803973957666 1318 5887985 SGTC_2141 5621638 7.665 µM 0.607112654320644 0.245959959590434 no 824 0.271888076406902 1373 2856238 SGTC_536 3852-0578 10.6 µM 0.606343562978054 0.246233113851707 no 825 0.272143318299963 1402 2869208 SGTC_1191 1487-1166 10.6 µM 0.605124967612995 0.246666248988726 no 826 0.272547982894299 1411 3955771 SGTC_1416 3966-0321 25.3 µM 0.604795026325579 0.246783592826308 no 827 0.272657599391673 1333 582530 YLR208W SEC13 SGTC_862 0452-0056 10.2 µM 0.604045516718 0.247050267433904 no 828 0.272906690482389 1273 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3177 9107506 49.47 µM 0.601835932738278 0.247837331058542 no 829 0.273641676967086 1289 8897194 SGTC_2293 7624732 200 µM 0.600982434233692 0.248141709007488 no 830 0.273925843012587 1287 894453 SGTC_740 k014-0057 261 µM 0.600691240618152 0.24824560120336 no 831 0.274022827147095 1390 4012779 SGTC_1875 nocodazole 6 µM 0.600381255313317 0.248356223389337 no 832 0.274126088632482 1339 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2040 5100729 123 µM 0.599008678393424 0.248846360471599 no 833 0.274583548703913 1364 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2759 disulfiram 3.38 µM 0.598984773345221 0.248854901347553 no 834 0.274591519246638 1299 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1115 galangin 695.678 nM 0.598446866020563 0.249047127938081 no 835 0.274770901214147 1377 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_409 arachidonic acid 100 µM 0.597958622412807 0.249221675071981 no 836 0.274933771269482 1367 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2409 alverine citrate 63.97 µM 0.5965702811934 0.249718362470279 no 837 0.275397158913829 1464 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_220 paclitaxel 373.376 µM 0.595955848956637 0.249938346973264 no 838 0.275602361000954 1353 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1 0258-0098 57.368 µM 0.59516628572595 0.250221184364237 no 839 0.275866161960477 1283 6790032 YDR047W HEM12 SGTC_1930 st074634 34.3 µM 0.593236850429186 0.250913060342182 no 840 0.276511327065894 1323 684253 YOR116C RPO31 SGTC_3287 9117173 37.0625 µM 0.592752296789779 0.251086975314976 no 841 0.276673468388116 1325 2789709 SGTC_2384 9036245 200 µM 0.592729042935258 0.251095323142853 no 842 0.276681250763572 1410 6462766 SGTC_1668 st014914 51.6 µM 0.592434627753096 0.251201027016086 no 843 0.276779792068931 1349 2839556 SGTC_2753 fluvastatin 17.09 µM 0.59063666494108 0.251847059887276 no 844 0.277381946354401 1376 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2685 mycophenolic acid 18.85 µM 0.590494832837972 0.251898059417547 no 845 0.277429474472693 1346 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2589 lobaric acid 100 µM 0.590265537660747 0.251980520166273 no 846 0.277506319997914 1329 73157 A novel microtubule depolymerizer. SGTC_1520 flindersine 88 µM 0.587290760881793 0.253051620256466 no 847 0.278504222575847 1502 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3142 9086498 49.47 µM 0.586461501827276 0.253350630182804 no 848 0.278782712602539 1299 25236367 SGTC_2561 acetosyringone 100 µM 0.584202073147648 0.254166264678892 no 849 0.279542183451885 1336 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1849 st056239 19.2 µM 0.582855894784596 0.254652877451682 no 850 0.279995156847427 1271 5393181 SGTC_669 0108-0021 26.2 µM 0.582425569665496 0.254808533016757 no 851 0.280140031276989 1567 17201 SGTC_394 menadione 8.33 µM 0.581251380320282 0.255233509547523 no 852 0.280535521747771 1355 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_477 mead ethanolamide 10 µM 0.580821900362709 0.255389044539115 no 853 0.280680246654975 1290 16061185 SGTC_931 2812-0076 566 µM 0.580107701328773 0.255647799398293 no 854 0.280920995304857 1375 3450959 SGTC_1907 st060210 83.7 µM 0.579978728633522 0.255694540894863 no 855 0.280964481220962 1430 688793 SGTC_718 1130-0073 349 µM 0.579824666855473 0.255750380871935 no 856 0.281016430724177 1436 6740020 SGTC_2803 7707263 71.43 µM 0.57966588635967 0.25580793781829 no 857 0.281069976231263 1365 2199229 SGTC_1928 4'-methoxychalcone 40.3 µM 0.579159551166381 0.255991526339672 no 858 0.28124076043578 1498 641818 SGTC_465 cgp-37157 41 µM 0.577267553479355 0.256678140328562 no 859 0.281879364368478 1323 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1229 0139-0193 12.2 µM 0.575526251439202 0.257310912561709 no 860 0.282467720893463 1428 3090752 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.574661642436424 0.257625404022472 no 861 0.28276007691367 1324 390807 SGTC_743 1275-0778 158 µM 0.574371486939537 0.257730989419516 no 862 0.282858221699847 1415 2849257 YMR203W TOM40 SGTC_3122 9126309 49.47 µM 0.573762631415554 0.2579526203538 no 863 0.283064219598278 1405 17591206 SGTC_1947 st076332 61.6 µM 0.573675638753349 0.257984294828354 no 864 0.283093658247672 1374 24208416 SGTC_462 ag-879 158 µM 0.571836637493488 0.258654356438794 no 865 0.283716326878725 1410 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_60 0986-0278 202 µM 0.57063697819768 0.259091951418891 no 866 0.284122873477431 1202 3110598 SGTC_844 0330-0132 15.3 µM 0.569678713514359 0.259441768640629 no 867 0.284447815080584 1404 2828079 SGTC_348 k064-0012 10.7 µM 0.567164917172391 0.260360595116263 no 868 0.285301070538853 1333 5066323 SGTC_456 gingerol 170 µM 0.56645375140249 0.260620839664322 no 869 0.285542681925414 1432 442793 A herb. SGTC_80 0159-0065 512.242 µM 0.565545249783796 0.260953492123837 no 870 0.285851477780571 1351 1548079 SGTC_2851 9015922 71.43 µM 0.563646170929694 0.261649554000254 no 871 0.286497479031571 1446 2996893 SGTC_1941 st076221 61.8 µM 0.563526516657916 0.261693442294614 no 872 0.286538204481359 1376 2828568 SGTC_1881 5652484 16 µM 0.563416474697852 0.261733808198915 no 873 0.28657566071511 1408 2255129 SGTC_2231 micatex 6.853 µM 0.562387799025806 0.262111304377558 no 874 0.28692591503801 1409 20737 An antifungal of unknown mechanism. SGTC_1321 1326-2144 215 µM 0.561403881763051 0.262472636331266 no 875 0.287261119199145 1424 3513030 SGTC_941 3237-0776 460 µM 0.560663470196483 0.262744711753071 no 876 0.287513487179268 1461 760008 SGTC_828 2074-0507 139 µM 0.560519793877116 0.262797524496864 no 877 0.287562471142551 1473 X828 SGTC_626 0214-0009 33 µM 0.559918850423423 0.263018478967592 no 878 0.287767395199191 1478 3437874 SGTC_2315 7733312 200 µM 0.55970794062575 0.263096048639021 no 879 0.287839332613084 1372 726316 SGTC_2455 5377712 9.75 µM 0.557180142988808 0.264026646000246 no 880 0.28870217765116 1350 2243908 SGTC_1308 1187-1617 41.4 µM 0.556840003517122 0.26415199473474 no 881 0.288818374659343 1395 2882570 SGTC_3282 9108498 15.4605 µM 0.556786678855589 0.264171648771436 no 882 0.288836593200772 1381 16459645 SGTC_2486 5283202 22.39 µM 0.556780345202573 0.264173983235156 no 883 0.288838757149554 1342 1377751 SGTC_2532 xanthone 78.9 µM 0.556356582266369 0.2643301980388 no 884 0.288983556851326 1432 7020 An insecticide. SGTC_2506 ethyl hematommate 54.16 µM 0.556288894423224 0.264355154654424 no 885 0.289006688935204 1351 3940691 An allergen. SGTC_542 3381-0244 89.3 µM 0.555823835745665 0.264526654956402 no 886 0.289165644660458 1496 1112843 SGTC_2456 5770359 74.46 µM 0.554734847923536 0.264928463795076 no 887 0.289538018315481 1466 3118787 SGTC_2449 5812982 45.77 µM 0.55034232995589 0.266552333969673 no 888 0.291042297887302 1395 776185 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.549455269119095 0.266880881384077 no 889 0.291346526874785 1456 65057 A dermal irritant. YDR527W RBA50 SGTC_2523 spermine 47.74 µM 0.549071755616811 0.267022989494236 no 890 0.291478103724282 1419 1103 A DNA binding polyamine. SGTC_1523 st012844 44.7 µM 0.548951428205604 0.267067583806383 no 891 0.291519391689419 1447 4274103 SGTC_1009 4106-0057 9.87 µM 0.548746210893119 0.267143647677464 no 892 0.291589814232827 1409 2928005 SGTC_3136 9095672 49.47 µM 0.547020789783168 0.267783607845381 no 893 0.292182224631911 1319 17217380 SGTC_1178 0988-0033 191 µM 0.546905360986813 0.267826448033475 no 894 0.292221876220857 1424 5392207 SGTC_247 mechlorethamine 29.705 µM 0.546721317135023 0.26789476112064 no 895 0.292285103327139 1388 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2262 9014885 67.46 µM 0.546616723559755 0.267933587898371 no 896 0.29232103862664 1384 6457424 SGTC_3337 9144342 33.5465 µM 0.545011626173585 0.268529780464839 no 897 0.292872760763976 1469 17682949 SGTC_2114 5491910 81.25 µM 0.544936644031852 0.268557647902313 no 898 0.29289854628252 1495 2849228 SGTC_763 3453-1109 128 µM 0.544077200706626 0.268877167515315 no 899 0.29319417443835 1415 1560353 SGTC_1635 st007035 42.4 µM 0.543762703923629 0.268994137271523 no 900 0.29330238844979 1452 3716403 SGTC_2965 9082772 38.63 µM 0.543719319729567 0.269010275017004 no 901 0.29331731780623 1471 16459634 SGTC_3237 9133362 49.47 µM 0.543267541094506 0.269178353309677 no 902 0.293472804665349 1458 43845137 SGTC_2331 7980721 200 µM 0.542781767988398 0.269359137558605 no 903 0.29364003384873 1462 2981221 SGTC_2205 7238770 200 µM 0.542617422800313 0.269420313681031 no 904 0.293696620270694 1443 279867 SGTC_2426 5582046 32.21 µM 0.542510427824193 0.269460145409561 no 905 0.293733462898576 1455 2251934 SGTC_2916 7875993 68.79 µM 0.540813864828019 0.270092130364597 no 906 0.294317942661968 1516 1299250 SGTC_2967 9089538 49.85 µM 0.539294692170076 0.270658664408854 no 907 0.294841765351596 1507 728216 SGTC_2907 7721985 69.9 µM 0.538313409444982 0.271024922262282 no 908 0.295180347638198 1383 3267881 SGTC_452 diindolylmethane 8 µM 0.536759554524218 0.27160539448218 no 909 0.295716856365218 1429 3071 Inhibits expression of several cancer promoting factors. SGTC_496 calpeptin 138 µM 0.536572525557026 0.2716753044466 no 910 0.295781463170885 1381 73364 A calpain inhibitor. SGTC_836 0330-0104 1.35 µM 0.534954952289673 0.272280314195856 no 911 0.296340503893255 1440 46494820 SGTC_3233 9132340 49.47 µM 0.534771485624143 0.27234897721317 no 912 0.296403941390515 1389 17682950 SGTC_1101 ebselen 5.29 µM 0.534216156813452 0.272556863299077 no 913 0.296595996051698 1498 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3119 9125183 49.47 µM 0.533100234720338 0.272974844274591 no 914 0.296982098299936 1351 22695334 SGTC_1114 scopoletin 1.73284 µM 0.533099782491652 0.272975013726254 no 915 0.296982254814905 1483 5280460 A coumarin with genotoxic properties. SGTC_895 0964-0006 13.7 µM 0.532413348194878 0.273232283149931 no 916 0.297219871114676 1398 6738897 SGTC_3261 9137475 49.47 µM 0.529895183572833 0.274177096044661 no 917 0.298092302876088 1402 17027690 SGTC_2848 9016370 25.97 µM 0.52915166754204 0.274456370786531 no 918 0.298350120963333 1473 7894410 SGTC_502 l-744,832 89.3 µM 0.529090701542765 0.274479276671703 no 919 0.298371265745576 1482 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1456 k015-0012 13 µM 0.527522163449642 0.2750689252582 no 920 0.298915514745869 1564 2989616 SGTC_1245 0418-0076 17.2 µM 0.526898533414835 0.275303534969523 no 921 0.299132026184193 1470 6790114 SGTC_2906 7926292 26.41 µM 0.526784942773384 0.275346278386227 no 922 0.299171470165841 1425 2966319 SGTC_371 0195-0006 7.36 µM 0.525873846577007 0.275689236037505 no 923 0.299487930723001 1366 3928593 SGTC_1490 4089-0339 670 nM 0.525251642776576 0.275923568524625 no 924 0.299704134429375 1437 742542 SGTC_1038 k292-0204 154 µM 0.524546480801537 0.276189262685535 no 925 0.299949249914539 1381 4454212 SGTC_1818 st052136 56.3 µM 0.524038735080437 0.276380651170659 no 926 0.300125799339077 1371 674169 SGTC_2591 skatole 100 µM 0.523618021632945 0.276539283179941 no 927 0.300272122167034 1453 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2596 sinensetin 100 µM 0.522775920995617 0.276856935261087 no 928 0.300565098971081 1438 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3216 9129716 49.47 µM 0.522775200276851 0.276857207202754 no 929 0.300565349772966 1390 8056934 SGTC_3202 9113761 49.47 µM 0.522519583934297 0.276953664633224 no 930 0.300654307294978 1608 4798415 SGTC_244 nsc-207895 1.295 µM 0.522466645729042 0.276973643046375 no 931 0.300672731904296 1360 42640 SGTC_1280 0880-0253 10.1 µM 0.522209962191711 0.277070523159273 no 932 0.300762075250219 1432 6836607 SGTC_1262 0737-0114 49.6 µM 0.521965794672895 0.277162694737737 no 933 0.300847073284561 1472 765919 SGTC_1439 4092-1168 46 µM 0.520974463459623 0.277537069558664 no 934 0.301192280406032 1462 2886240 SGTC_3004 9076122 71.4286 µM 0.520836204692688 0.277589302414305 no 935 0.301240439853818 1515 44782551 SGTC_2520 obtusaquinone 4.71 µM 0.519810257101998 0.277977045706906 no 936 0.301597914788084 1547 5967872 SGTC_572 0960-0087 17.7 µM 0.519322676617845 0.278161412893815 no 937 0.301767871229173 1396 6796365 SGTC_767 0929-0023 86 µM 0.518477580341592 0.278481107528852 no 938 0.302062549257425 1473 1204563 SGTC_754 3474-0146 171 µM 0.51769541513183 0.278777155156457 no 939 0.302335398828739 1369 24762078 SGTC_2816 7982706 58.44 µM 0.512716469553234 0.280665256764766 no 940 0.304074833682809 1439 2981853 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.511695923455162 0.281053027928321 no 941 0.304431919806026 1545 688761 SGTC_2152 5568786 200 µM 0.509229487221336 0.281991253113674 no 942 0.305295688277483 1450 5399883 SGTC_2373 9071805 200 µM 0.508600489432747 0.282230763234598 no 943 0.305516142918234 1574 10149009 SGTC_804 1595-0054 20.9 µM 0.508566253722956 0.282243802335765 no 944 0.30552814406476 1439 761523 Stimulates phospholipase C. SGTC_986 1493-0483 84 µM 0.50702369292286 0.28283160664427 no 945 0.306069097226196 1461 40079 SGTC_2150 5556613 200 µM 0.506655033757767 0.282972173976079 no 946 0.306198443220185 1489 743190 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.505421394137622 0.28344279645367 no 947 0.306631447755634 1494 4213774 SGTC_2890 9046729 58.44 µM 0.503210145333573 0.2842873058486 no 948 0.307408266325045 1409 903329 SGTC_722 3534-0461 190 µM 0.502411418844784 0.284592646996214 no 949 0.307689074188606 1451 658262 SGTC_2034 5197015 53.07 µM 0.50228312751798 0.284641705437709 no 950 0.307734188013729 1568 780676 SGTC_1503 4585-0012 61.3 µM 0.501406391463892 0.284977076231066 no 951 0.308042571268789 1536 2922052 SGTC_2964 9083345 53.42 µM 0.501262011372976 0.285032322852562 no 952 0.308093368549193 1432 17741579 SGTC_2975 9084847 53.72 µM 0.49967399085468 0.285640311010554 no 953 0.308652324595285 1484 27211724 SGTC_1409 3909-8004 61.9 µM 0.497080302996844 0.286634653050839 no 954 0.30956621201537 1491 2119279 SGTC_2521 angolensin 13.4 µM 0.497022551191643 0.286656812028763 no 955 0.309586574332923 1526 821428 A flavenoid. SGTC_1194 1488-0194 225 µM 0.496447273262846 0.286877586624382 no 956 0.309789439579436 1492 1391452 SGTC_786 4544-0069 423 µM 0.49446972635404 0.287637124326254 no 957 0.310487240747002 1548 748821 YLR208W SEC13 SGTC_3083 9117465 49.47 µM 0.493235330378461 0.288111713353392 no 958 0.310923158375363 1460 16420915 SGTC_1133 3473-0247 50 µM 0.493153176060923 0.28814331238736 no 959 0.31095217998118 1422 711311 SGTC_1977 st070720 65.3 µM 0.492969216848766 0.288214074590741 no 960 0.311017169165045 1480 682188 SGTC_2770 toltrazuril 17.5 µM 0.49230899111426 0.288468106126545 no 961 0.311250462499561 1508 68591 Kills coccidiodes. SGTC_2190 6049624 200 µM 0.491563411742935 0.288755105532521 no 962 0.311514007051663 1509 2265554 SGTC_132 0417-1715 25.805 µM 0.491555654289922 0.288758092352281 no 963 0.311516749634561 1617 6769098 SGTC_2626 ethyl orsellinate 100 µM 0.49128935978815 0.288860631432133 no 964 0.311610902178067 1457 75653 A natural product. SGTC_1423 4048-0112 5.59 µM 0.491055008851411 0.288950884531617 no 965 0.311693770770484 1570 X1423 SGTC_3330 9141424 71.43 µM 0.490667920133216 0.289099988969451 no 966 0.311830669696349 1572 27261020 SGTC_2723 salbutamol 83.58 µM 0.488655322948278 0.28987581283711 no 967 0.312542869421881 1524 9884233 β2-adrenoceptor agonist SGTC_1360 1598-0022 39.8 µM 0.488223202079665 0.29004251574097 no 968 0.312695875912349 1578 761525 SGTC_1165 k072-0275 30.3 µM 0.48793500217718 0.290153722017283 no 969 0.312797940436643 1497 6153523 YGL055W OLE1 SGTC_1332 1480-0653 17.5 µM 0.48737268150282 0.290370759427602 no 970 0.31299712475205 1495 5749438 SGTC_2697 mebhydrolin 72.4 µM 0.483531785730176 0.291855248594512 no 971 0.314359098148637 1630 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_751 0833-0568 350 µM 0.483441503619936 0.291890184715567 no 972 0.314391142506457 1533 6954252 SGTC_2297 7971671 152.32 µM 0.482703240943557 0.292175940444776 no 973 0.314653230862124 1600 909016 SGTC_2176 5809774 33.9695 µM 0.479902365310153 0.293261243611382 no 974 0.315648409637722 1551 2870539 SGTC_2193 5925765 200 µM 0.476751463142121 0.294484406321311 no 975 0.316769555937345 1557 877370 SGTC_3347 9188721 44.724 µM 0.476255684797749 0.294677078910974 no 976 0.316946116256817 1531 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1112 tnp00069 1.16933 µM 0.47595758284982 0.294792957202826 no 977 0.317052298642553 1602 145826 SGTC_2968 9090663 33.37 µM 0.475177152471705 0.295096425818223 no 978 0.317330355278925 1529 25236811 SGTC_2798 7813637 45.45 µM 0.474359921918395 0.29541435822006 no 979 0.317621633854412 1580 956368 SGTC_380 3970-0968 6 µM 0.474109435822931 0.29551183796027 no 980 0.317710935115643 1478 2891601 SGTC_1164 k060-0068 93.7 µM 0.473671854757095 0.295682163486962 no 981 0.317866963395309 1544 5963676 SGTC_1745 st081495 74 µM 0.473083902872691 0.295911090867725 no 982 0.318076660317972 1533 13842402 YBL026W LSM2 SGTC_2248 tofa 1.1 µM 0.47226303149828 0.296230844816089 no 983 0.318369527080286 1527 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_893 0958-0369 48.9 µM 0.472145005396467 0.296276832540862 no 984 0.31841164523814 1627 6819948 SGTC_2977 9011197 71.43 µM 0.471014274431566 0.29671757672342 no 985 0.318815270678927 1582 2704722 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.470182253426465 0.297042079259684 no 986 0.319112406031735 1627 23847180 SGTC_1081 sertraline 6 µM 0.470021593302917 0.297104758169425 no 987 0.319169795147042 1599 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3090 9117696 49.47 µM 0.469891188005758 0.297155638101345 no 988 0.319216380176476 1610 7923821 SGTC_313 3474-0040 5.03 µM 0.468772931066351 0.297592109255828 no 989 0.319615975195984 1497 1043375 YIL048W NEO1 SGTC_149 3970-0822 46.1 µM 0.467796486078608 0.29797346838594 no 990 0.319965066870083 1562 3114250 YBL034C STU1 SGTC_2111 5486399 200 µM 0.467758986239121 0.297988118717017 no 991 0.319978476728164 1503 689674 SGTC_2181 6316240 54.2555 µM 0.465892211276135 0.298717839644134 no 992 0.320646328256369 1490 12779990 SGTC_619 1652-1634 108 µM 0.463391243423906 0.299696737146639 no 993 0.321541977056389 1529 5400454 SGTC_2386 9075165 157.42 µM 0.463389304025166 0.299697496805347 no 994 0.32154267199914 1498 16452277 SGTC_2519 cryptotanshinone 88.04 µM 0.462536709005895 0.30003154105169 no 995 0.321848241952652 1603 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1331 1472-0049 76.2 µM 0.462195856635232 0.300165133134149 no 996 0.321970437135555 1502 24051409 SGTC_621 3584-0052 32.1 µM 0.461437377508036 0.30046250437087 no 997 0.322242420100082 1597 2273927 SGTC_38 0929-0051 58.268 µM 0.459844456458744 0.301087461790712 no 998 0.322813935314031 1660 1379719 SGTC_2899 9053889 58.44 µM 0.458823489773893 0.301488329755499 no 999 0.323180462527477 1570 6470052 SGTC_492 tmb-8 126 µM 0.458659403641845 0.301552778223467 no 1000 0.323239385503143 1528 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1205 4161-2785 76 µM 0.458322762070875 0.301685021066076 no 1001 0.323360286645125 1464 3498106 SGTC_539 4859-0462 2.54 µM 0.457394836830275 0.302049672692912 no 1002 0.323693637404864 1649 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_114 0364-0001 490.298 µM 0.456663809262188 0.302337087723038 no 1003 0.323956353698892 1470 4003655 SGTC_997 3996-0078 137 µM 0.455190998098832 0.302916518921481 no 1004 0.324485918058772 1554 735687 SGTC_1311 1190-0148 100 µM 0.453620996433818 0.303534733419882 no 1005 0.32505081930983 1645 1961333 SGTC_2239 6685329 187.64 µM 0.453051471918105 0.30375913244399 no 1006 0.325255839080175 1530 805680 SGTC_1835 st008666 49.2 µM 0.45211792947918 0.304127118617627 no 1007 0.325592013928447 1489 690455 SGTC_1799 st045822 46.1415 µM 0.451072480033368 0.304539452203836 no 1008 0.325968655681942 1632 3674992 SGTC_1105 epirubicin 18.1 µM 0.450593146272512 0.304728588380995 no 1009 0.32614140361333 1495 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2546 rhodinyl acetate 100 µM 0.448217295270152 0.305666824821028 no 1010 0.326998190935194 1660 6708682 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.447985626078495 0.305758380683644 no 1011 0.327081785162099 1645 756377 SGTC_2765 myclobutanil 7.74 µM 0.446798154480523 0.306227861010976 no 1012 0.327510401964896 1564 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2074 5212007 75.395 µM 0.446499499468691 0.306345987783322 no 1013 0.327618237039956 1647 758611 SGTC_2952 9073731 13.78 µM 0.445608131685316 0.306698669416559 no 1014 0.32794016782055 1507 16457353 SGTC_653 0203-0016 55.2 µM 0.444321517814138 0.307208051159255 no 1015 0.328405073108973 1600 295302 SGTC_1773 st048542 73.5835 µM 0.443636035754776 0.307479591583602 no 1016 0.328652873909818 1479 3237138 SGTC_1895 st058434 18.3 µM 0.442742560388403 0.307833682948086 no 1017 0.328975977126191 1668 5393175 SGTC_778 3456-2434 196 µM 0.441873372016753 0.308178320998865 no 1018 0.329290420227886 1718 5539063 SGTC_474 dl-dihydrosphingosine 5 µM 0.441635639437741 0.308272612773911 no 1019 0.329376444919564 1615 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2859 9028643 45.46 µM 0.441438078150196 0.308350981052373 no 1020 0.329447940305806 1594 17151580 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.44097650164931 0.30853411247922 no 1021 0.329615004365401 1596 7104 SGTC_1811 st050069 61.5 µM 0.440785174851244 0.308610035749319 no 1022 0.329684263598035 1583 3877702 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.440566499478971 0.308696821640449 no 1023 0.32976343001496 1597 66535 A nucleotide analog. SGTC_2946 9065502 71.43 µM 0.439941325543995 0.30894499391172 no 1024 0.329989802002088 1498 16489101 SGTC_139 0099-0334 718.624 µM 0.439562927540155 0.309095247127089 no 1025 0.330126848059865 1601 97690 SGTC_1188 1403-0014 4.57 µM 0.437691439750258 0.309838841500852 no 1026 0.330804987851412 1564 9614867 SGTC_2671 danthron 100 µM 0.434258846756721 0.311204729112925 no 1027 0.332050242264327 1576 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2934 9036370 36.88 µM 0.431637999053729 0.312249363761699 no 1028 0.333002268088805 1697 6462800 SGTC_2570 licareol 100 µM 0.431439742075323 0.312328447909011 no 1029 0.333074329063183 1545 443158 SGTC_715 0868-0130 184 µM 0.43027176405495 0.312794526447959 no 1030 0.333498982088971 1730 2876258 SGTC_2809 7964133 12.99 µM 0.43019767447729 0.312824101805318 no 1031 0.333525926755621 1601 1253665 SGTC_2606 farnesol 9.78 µM 0.429474339533162 0.313112908659435 no 1032 0.333789032056952 1665 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_671 0560-0003 407 µM 0.428738552549998 0.313406804931207 no 1033 0.33405675052317 1637 3238678 SGTC_83 0170-0301 39.027 µM 0.42613242168707 0.314448727236415 no 1034 0.335005678270488 1597 3089716 SGTC_1997 st073024 93.8 µM 0.42590252766081 0.314540709231967 no 1035 0.335089436503289 1614 686268 SGTC_3292 9120825 59.784 µM 0.425619255870777 0.314654063826981 no 1036 0.335192653353934 1716 24824900 SGTC_2420 aureobasidin a 50 nM 0.42559178526906 0.314665057446245 no 1037 0.335202663586652 1714 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1933 st074711 15.9 µM 0.425258387293787 0.314798495007981 no 1038 0.335324162474389 1541 17250958 SGTC_708 3448-5400 146 µM 0.425144632883004 0.314844029046881 no 1039 0.335365621480623 1577 3462195 SGTC_2600 tangeritin 87.95 µM 0.424929136337808 0.314930296522898 no 1040 0.335444166987826 1513 68077 A bioactive flavone. SGTC_1948 st076329 66.6 µM 0.423849384879247 0.315362694100927 no 1041 0.335837829694167 1534 24208413 SGTC_3153 9100258 49.47 µM 0.423829061289894 0.315370835319004 no 1042 0.33584524112764 1543 25236848 SGTC_1174 0739-0097 51.1 µM 0.422800620916896 0.315782924661498 no 1043 0.33622036730261 1602 728447 SGTC_1138 3761-0006 1.03 µM 0.42256083460847 0.315879038422715 no 1044 0.336307853419019 1606 12061087 SGTC_497 capsazepine 133 µM 0.422157271210588 0.316040827207454 no 1045 0.336455113675218 1512 2733484 A calcium channel blocker. SGTC_1980 st071811 45.7 µM 0.420217667595819 0.316818906564479 no 1046 0.337163224635202 1660 4974850 SGTC_1394 3474-0001 65.7 µM 0.418686540816142 0.317433696904627 no 1047 0.337722616676289 1567 5017666 YIL048W NEO1 SGTC_14 0354-0009 295 µM 0.418144052265727 0.317651642272328 no 1048 0.337920899171323 1641 1713507 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.415975149758394 0.31852363214242 no 1049 0.33871409370972 1657 676296 Flavone; oxidizing agent. SGTC_739 1486-1183 203 µM 0.414630307056961 0.319064821075956 no 1050 0.339206279152114 1726 4346692 SGTC_2086 5274770 176.623 µM 0.414331510988659 0.319185114430963 no 1051 0.339315669815948 1607 689278 SGTC_2974 9094440 9.66 µM 0.414022895737761 0.31930938091454 no 1052 0.3394286695476 1709 25236134 SGTC_2584 androsterone 48.74 µM 0.414004669082157 0.31931672066319 no 1053 0.339435343704419 1621 2754130 A steroid. SGTC_1273 0849-0096 14.1 µM 0.413280397113387 0.319608437281062 no 1054 0.339700595181312 1584 5286025 SGTC_1771 st048882 4.1505 µM 0.412932492271057 0.319748603389558 no 1055 0.339828037262486 1529 4580403 SGTC_280 3448-3607 3.04 µM 0.412371727697867 0.319974581962779 no 1056 0.340033491174387 1681 626179 SGTC_2337 9009472 200 µM 0.411719892806135 0.320237344296099 no 1057 0.340272371303323 1702 5742383 SGTC_3139 9095020 49.47 µM 0.411647451108275 0.320266551968583 no 1058 0.340298923216769 1516 25236292 SGTC_990 3985-0011 41.3 µM 0.410956437078058 0.320545216954891 no 1059 0.340552239017213 1602 5399565 YGL099W LSG1 SGTC_738 1315-0003 72.4 µM 0.410324312034655 0.320800222428351 no 1060 0.340784029975219 1691 6251474 SGTC_3310 9130229 44.1445 µM 0.40990888875653 0.320967854336606 no 1061 0.340936392329804 1684 7761258 SGTC_45 0kpi-0036 14.9 µM 0.409543942112447 0.321115147994374 no 1062 0.34107026307639 1636 2795021 SGTC_656 4090-1979 187 µM 0.409040308422142 0.321318462421362 no 1063 0.34125504025052 1730 22330961 SGTC_1302 1159-0335 255 µM 0.409018741760599 0.32132716997205 no 1064 0.341262953650842 1594 649284 SGTC_2443 5493264 126.67 µM 0.408247128851664 0.321638773663082 no 1065 0.34154612551841 1720 5340055 SGTC_2693 st077581 40.7 µM 0.40814104617386 0.321681623297016 no 1066 0.341585063455785 1627 25238761 SGTC_1749 st037932 54.2 µM 0.407058335372125 0.322119094751457 no 1067 0.341982571769562 1589 594497 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.407016085517278 0.322136170891729 no 1068 0.341998087009143 1582 115019 SGTC_2012 4023501 200 µM 0.404500326195466 0.323153642036717 no 1069 0.342922419032634 1569 3477460 SGTC_1177 0983-0204 23.6 µM 0.402868648972949 0.323814264576242 no 1070 0.343522427955666 1762 766818 SGTC_899 1083-0020 478 µM 0.402250912433581 0.324064514669951 no 1071 0.343749688315491 1711 767123 SGTC_2836 9010338 19.48 µM 0.402135791611497 0.324111159844881 no 1072 0.34379204659584 1494 2994051 SGTC_2617 dihydrotanshinone i 20.83 µM 0.400409851900815 0.32481081458112 no 1073 0.344427334548507 1593 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3190 9110366 49.47 µM 0.40019881307458 0.324896407164716 no 1074 0.344505044382507 1745 17123768 SGTC_1155 4088-0394 48.2 µM 0.400009737388329 0.324973099846049 no 1075 0.344574672407294 1576 2326248 SGTC_3021 9087658 49.47 µM 0.398901118743901 0.325422925737655 no 1076 0.344983032415782 1651 25237042 SGTC_2646 retinol 96.75 µM 0.396140135540436 0.326544309086205 no 1077 0.346000825585471 1646 445354 A vitamin A analog and teratogen. SGTC_805 3852-0218 479 µM 0.394985122239589 0.327013888072928 no 1078 0.346426933937747 1587 6615355 SGTC_2988 9073640 71.4286 µM 0.394463013061985 0.327226245300817 no 1079 0.346619614679406 1666 9102229 SGTC_226 1,3-diallylurea 8.28947 mM 0.394048204231296 0.327395000186491 no 1080 0.346772725271346 1661 74537 YKL182W FAS1 SGTC_81 0411-0046 9.971 µM 0.393270059288432 0.327711664677309 no 1081 0.347060014794336 1595 12925265 SGTC_1765 st044815 90.4 µM 0.391086790954249 0.328600802422299 no 1082 0.347866541983131 1561 645695 SGTC_2976 9009005 19.48 µM 0.390572060902962 0.328810568319033 no 1083 0.34805679031495 1786 2993148 SGTC_2382 9035899 200 µM 0.390294489742984 0.328923708184033 no 1084 0.34815939870723 1634 6462679 SGTC_189 3970-0742 2.116 µM 0.388413024554884 0.329691018831993 no 1085 0.348855203586541 1741 2891807 SGTC_936 3005-4620 401 µM 0.387740677472725 0.329965393696211 no 1086 0.349103974968047 1747 777207 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.387668186563622 0.329994981627001 no 1087 0.34913080079902 1594 16623 A steroid. SGTC_1755 st041960 45.185 µM 0.387519190617991 0.330055799236329 no 1088 0.34918594028742 1652 2257073 SGTC_366 0181-0206 4.31 µM 0.386404256771387 0.330511038718107 no 1089 0.349598649016088 1816 274874 SGTC_551 k048-0028 34.9 µM 0.385398914300377 0.330921746015003 no 1090 0.349970943417793 1727 6836383 SGTC_2894 9048625 32.47 µM 0.384695933013585 0.331209052257466 no 1091 0.350231354368384 1766 4092861 SGTC_443 clozapine 122 µM 0.384337575933967 0.331355549928807 no 1092 0.350364130543061 1741 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_302 1094-0063 18.9 µM 0.383520578362466 0.331689637962297 no 1093 0.350666907614635 1638 5440289 SGTC_3348 9149464 3.537 µM 0.382857972762169 0.331960690133787 no 1094 0.350912537134162 1634 1951442 SGTC_1139 k015-0024 46.9 µM 0.382766390380438 0.331998160674656 no 1095 0.350946491851616 1751 2766652 SGTC_2667 digitoxin 100 µM 0.382644996016197 0.332047831250577 no 1096 0.350991501374947 1733 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3034 9090421 49.47 µM 0.382197479372045 0.332230965811817 no 1097 0.351157445674769 1737 17173761 SGTC_3007 9078383 71.4286 µM 0.381994730016397 0.33231394891064 no 1098 0.351232636804151 1642 6496995 SGTC_1662 st014054 52 µM 0.381822934580173 0.332384269342636 no 1099 0.351296352996825 1652 2838777 SGTC_1027 k015-0025 8.67 µM 0.380906160974789 0.332759628821275 no 1100 0.35163644035939 1612 3598955 SGTC_2750 bromebric acid 70.15 µM 0.380815110985563 0.332796917061598 no 1101 0.351670222853491 1682 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3105 9121040 49.47 µM 0.379149032241809 0.333479527833434 no 1102 0.352288598594108 1647 41448907 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.378363291034157 0.33380164625001 no 1103 0.352580367133796 1591 6708514 SGTC_1297 1068-0111 14.1 µM 0.376214743582141 0.334683078677871 no 1104 0.353378627717089 1602 767057 SGTC_3128 9127691 49.47 µM 0.375451963221795 0.334996225631973 no 1105 0.353662182748261 1664 41316314 SGTC_1124 fisetin 1.16336 µM 0.374405546668037 0.335426001417572 no 1106 0.354051308453933 1630 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_920 mycophenolic acid 780.421 nM 0.373356566625315 0.335857046316031 no 1107 0.354441540475087 1624 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2825 7998094 58.44 µM 0.373158791833814 0.335938339779513 no 1108 0.354515131993823 1681 2987815 SGTC_1063 disulfiram 1.84 µM 0.373152568346977 0.335940898009693 no 1109 0.354517447826291 1666 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1036 k216-0215 33.5 µM 0.371010835749019 0.336821730557219 no 1110 0.355314730518517 1630 622330 SGTC_1684 st024538 14.6195 µM 0.369728512120708 0.337349542169595 no 1111 0.355792392631435 1645 6732859 SGTC_405 ebelactone b 50 µM 0.369003577124538 0.337648071252093 no 1112 0.356062529243272 1648 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_54 0159-0055 9 µM 0.367524899621211 0.338257309014892 no 1113 0.356613761093719 1781 3319099 SGTC_2097 5376186 200 µM 0.36691394685158 0.338509154705215 no 1114 0.356841603925512 1773 742755 SGTC_213 1246-0773 967 nM 0.366911644457066 0.338510103930237 no 1115 0.356842462654968 1703 6251622 SGTC_1940 st075990 51.1 µM 0.36406273689561 0.339685428299535 no 1116 0.357905580909862 1750 1084979 SGTC_2915 7971052 15.16 µM 0.363899989696708 0.339752617313589 no 1117 0.357966346174433 1666 5741558 SGTC_47 0149-0135 24.25 µM 0.363314202719856 0.339994497400608 no 1118 0.358185092471399 1565 5239155 SGTC_134 0269-0018 6.916 µM 0.363252320370553 0.340020053384717 no 1119 0.358208203480606 1629 4378915 SGTC_2407 paclitaxel 400 µM 0.362696515046178 0.340249621113726 no 1120 0.358415801651096 1778 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_266 formosanin C 406 nM 0.361825649152888 0.340609439339899 no 1121 0.358741161855511 1712 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2108 5365811 200 µM 0.361760598687861 0.34063632226025 no 1122 0.358765469179121 1742 780283 SGTC_3130 9127414 49.47 µM 0.361376869212897 0.340794919746299 no 1123 0.358908868515274 1675 1494646 SGTC_2544 sphondin 68.51 µM 0.360622193133904 0.34110691357329 no 1124 0.359190948238693 1772 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1048 3161-0300 24.5 µM 0.36039281941575 0.341201761474859 no 1125 0.359276697825221 1639 2165101 SGTC_3175 9106517 49.47 µM 0.360115951340569 0.341316262045019 no 1126 0.359380212251029 1662 41468073 SGTC_771 0250-0039 27.3 µM 0.359954598237626 0.341382997395568 no 1127 0.359440543121193 1692 3005115 SGTC_1433 4060-0023 7.6 µM 0.35971484933509 0.341482166266658 no 1128 0.359530193111032 1730 3840627 SGTC_2196 6573537 42.6665 µM 0.359600686750101 0.341529391913565 no 1129 0.359572884969238 1779 2903087 SGTC_2983 9022671 12.99 µM 0.359227095740046 0.341683952681567 no 1130 0.359712604062769 1835 6405161 SGTC_3355 9151058 44.0485 µM 0.358522429709252 0.34197555689189 no 1131 0.359976192747684 1695 17015728 SGTC_1654 st012436 41.8 µM 0.357249726828001 0.342502464398138 no 1132 0.36045243104631 1771 4323132 SGTC_416 estradiol valerate 100 µM 0.357178024328552 0.342532158846737 no 1133 0.360479268171494 1709 13791 A steroid. SGTC_2662 daunorubicin 22.37 µM 0.356855499630405 0.342665739348167 no 1134 0.360599992623861 1681 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2699 st077704 54.6 µM 0.355794329641991 0.343105384390969 no 1135 0.360997297940438 1693 645852 SGTC_1078 idebenone 36.1 µM 0.354386428048752 0.34368900897811 no 1136 0.361524652151045 1697 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1374 2889-5571 141 µM 0.353720988857844 0.343964986677242 no 1137 0.361773995709058 1672 2853281 SGTC_389 tpck 16.7 µM 0.353529014350343 0.344044619754814 no 1138 0.361845940478557 1700 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2355 9061122 103.12 µM 0.35326955626815 0.344152256732058 no 1139 0.361943183293117 1810 5302957 SGTC_3244 9134489 49.47 µM 0.353108188724695 0.344219206919517 no 1140 0.362003667054238 1647 16584271 SGTC_583 1488-1091 88.9 µM 0.352332134014421 0.344541254390119 no 1141 0.362294595896609 1834 4303273 SGTC_2847 9005661 71.43 µM 0.351478162145427 0.344895766211343 no 1142 0.36261482640542 1718 2991449 SGTC_2997 9067075 71.4286 µM 0.351117387483381 0.345045576589997 no 1143 0.362750142022937 1753 27209819 SGTC_525 k781-2675 26.7 µM 0.350549983848971 0.345281238040848 no 1144 0.362962992566342 1716 3651118 YDL195W SEC31 SGTC_295 k015-0027 31 µM 0.350299326243338 0.345385363528206 no 1145 0.36305703542598 1715 3887424 SGTC_2348 9022543 33.42 µM 0.348859626871308 0.345983654393935 no 1146 0.36359734814818 1733 3162678 YDL140C RPO21 SGTC_1843 st055809 45.5 µM 0.348448525721915 0.346154564945851 no 1147 0.363751682431057 1686 16413835 SGTC_821 1114-0266 29.2 µM 0.347715077782646 0.346459565266217 no 1148 0.364027086013961 1678 3123235 SGTC_732 3970-1727 52.7 µM 0.347523801971614 0.346539122646108 no 1149 0.364098920039077 1846 1275699 SGTC_2760 etidronate 98.04 µM 0.347283063098327 0.346639262827085 no 1150 0.364189336805993 1660 3305 A chelator and antioxidant. SGTC_930 2810-3379 265 µM 0.344555811375288 0.34777446500874 no 1151 0.365214165501942 1841 1015764 SGTC_719 2810-4230 27.3 µM 0.342294982408464 0.348716557727293 no 1152 0.366064455615923 1730 721079 SGTC_2674 ligustilide 100 µM 0.342010963236504 0.348834975309467 no 1153 0.366171320885499 1721 5319022 A signalling regulator. SGTC_3242 9133940 49.47 µM 0.341841132976519 0.348905790554313 no 1154 0.36623522630833 1758 17248444 SGTC_2774 tamoxifen 10.92 µM 0.34159992568586 0.34900637739657 no 1155 0.366325996568027 1707 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2593 nobiletin 86.24 µM 0.341006080526621 0.349254064409698 no 1156 0.366549502106536 1656 72344 An anti-infammatory. SGTC_2349 9023730 187.07 µM 0.340855474992546 0.349316890718839 no 1157 0.366606192718879 1816 4126287 SGTC_2436 5633522 8.09 µM 0.33992301292786 0.349705966627841 no 1158 0.366957252836984 1847 5724242 SGTC_444 curcumin 90.4 µM 0.339548850929092 0.349862132590898 no 1159 0.367098151378173 1749 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_191 3914-0123 66.505 µM 0.338734261951959 0.350202209701449 no 1160 0.36740496381569 1682 3144412 SGTC_141 0443-0274 32.331 µM 0.338110504583467 0.350462699089951 no 1161 0.367639957363561 1858 1627241 SGTC_335 4077-0256 27.6 µM 0.338017754937388 0.350501438588301 no 1162 0.367674903980757 1810 3121989 SGTC_3020 9089140 49.47 µM 0.337487380344109 0.35072299431291 no 1163 0.367874761876876 1714 17217859 SGTC_894 0960-0238 55.9 µM 0.33582739143255 0.35141675669356 no 1164 0.368500516594104 1774 6741907 YDL195W SEC31 SGTC_2843 9000894 45.46 µM 0.335513245983959 0.351548103914745 no 1165 0.368618977177118 1692 2242070 SGTC_1395 3486-0190 4.35 µM 0.335040096561183 0.351745965671739 no 1166 0.36879741986589 1861 6748079 SGTC_414 piperonyl butoxide 100 µM 0.334377017614584 0.352023319782977 no 1167 0.369047539815026 1684 5794 A potent inhibitor of cytochrome P450. SGTC_1328 1441-0025 69.2 µM 0.334204142354594 0.352095643371908 no 1168 0.369112759195002 1630 4562601 SGTC_1552 6-methylflavone 10.6 µM 0.333833826899495 0.352250585467261 no 1169 0.369252478066695 1837 689013 SGTC_2179 6298986 200 µM 0.331104344568244 0.353393371557626 no 1170 0.370282835034792 1869 738374 SGTC_2416 tofa 880 nM 0.330723942735939 0.353552744364156 no 1171 0.370426507695673 1609 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_580 1123-0028 41 µM 0.33057009130642 0.353617209113368 no 1172 0.370484620448308 1773 1677248 YPR107C YTH1 SGTC_3250 9135583 49.47 µM 0.329879328778025 0.353906694821497 no 1173 0.370745571636273 1819 7699353 SGTC_2866 9034245 58.44 µM 0.328540651077836 0.3544679500836 no 1174 0.371251456654281 1862 6462273 SGTC_1180 1193-0155 285 µM 0.327621797080636 0.354853372735401 no 1175 0.37159881954531 1702 2921347 SGTC_1616 st002734 56.1 µM 0.326932404032478 0.355142643256805 no 1176 0.37185950587144 1767 4026101 SGTC_3183 9108214 49.47 µM 0.325915393831487 0.355569534922457 no 1177 0.372244184238101 1802 4974831 SGTC_622 1348-1566 26.3 µM 0.324345761275938 0.356228746273619 no 1178 0.372838139059761 1824 7340407 SGTC_1290 0986-0249 10.2 µM 0.323390542708136 0.356630127742909 no 1179 0.373199745458479 1810 53329 SGTC_2423 st077119 87.2 µM 0.32334116466569 0.356650880646266 no 1180 0.373218440990567 1729 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2955 9076254 12.21 µM 0.322924080396028 0.356826192279948 no 1181 0.373376369490942 1882 16459619 SGTC_876 0720-0963 56.8 µM 0.319442491886113 0.358290773436519 no 1182 0.374695496709952 1889 765861 SGTC_1725 st036284 20.55 µM 0.3187244513185 0.358593088054954 no 1183 0.374967735717554 1895 707914 SGTC_1485 3909-9022 254 µM 0.318203424164293 0.358812510166792 no 1184 0.375165317774568 1813 714516 SGTC_1408 3909-7976 48.8 µM 0.317896974144213 0.358941588378654 no 1185 0.375281543960832 1784 24152374 SGTC_1693 xanthone 101.9 µM 0.317633170939748 0.359052716450352 no 1186 0.375381604713786 1813 7020 An insecticide. SGTC_1600 coumarin 106 71.1 µM 0.315846951342114 0.359805481424861 no 1187 0.37605933942021 1789 100336 A hepatotoxic, DNA x-linker. SGTC_3236 9132701 49.47 µM 0.314960416398317 0.360179295325401 no 1188 0.376395854256406 1724 24282524 SGTC_1724 st037281 8.293 µM 0.314721212259935 0.36028018041203 no 1189 0.376486668525178 1706 574124 YDL195W SEC31 SGTC_1909 st060837 51.5 µM 0.31468707334055 0.360294579400623 no 1190 0.376499629983149 1714 678937 SGTC_1412 3909-8563 178 µM 0.314206772155715 0.360497180075573 no 1191 0.376681999766061 1873 23767530 SGTC_385 1494-0393 12.4 µM 0.313913857631544 0.36062075653048 no 1192 0.376793232572802 1798 3090647 SGTC_2931 9014674 55.67 µM 0.313880850709741 0.360634682592281 no 1193 0.376805767425538 1698 2996810 SGTC_1656 st012921 11 µM 0.313698190271495 0.360711752815573 no 1194 0.376875137698653 1844 6732821 SGTC_186 3455-3465 67.277 µM 0.31356930577697 0.360766136669769 no 1195 0.376924087485487 1764 755278 SGTC_1863 st057641 20.1 µM 0.313329125269028 0.360867490288354 no 1196 0.377015312306141 1889 3921635 SGTC_3106 9121286 49.47 µM 0.311590963400326 0.36160126694547 no 1197 0.377675701368708 1844 15943471 SGTC_1008 4106-0037 6 µM 0.310774245936056 0.361946225715716 no 1198 0.377986124823649 1779 2905394 SGTC_652 0437-0092 114 µM 0.308128651123699 0.363064420492115 no 1199 0.378992220351647 1733 3091274 SGTC_327 1273-0057 3.96 µM 0.306182690247465 0.363887652305626 no 1200 0.379732775554284 1803 3108138 SGTC_3248 9135562 49.47 µM 0.305842858349936 0.364031481563127 no 1201 0.379862147380199 1779 17650701 SGTC_349 k015-0014 24 µM 0.304913500134106 0.364424917638311 no 1202 0.380216016729558 1725 2196908 SGTC_269 exalamide 29 µM 0.303053304868861 0.365212844685601 no 1203 0.380924619515439 1794 3316 A derivative of salicylamide. SGTC_1037 k284-1091 78.7 µM 0.302412357265096 0.365484464339401 no 1204 0.381168867876284 1741 3334711 SGTC_2075 5212009 200 µM 0.302137769634768 0.365600849257626 no 1205 0.381273520529637 1867 780898 SGTC_1387 3342-1166 1.8 µM 0.302012927837106 0.36565376797848 no 1206 0.38132110393269 1797 3418228 SGTC_1912 st060209 90.8 µM 0.301643424891887 0.36581041017456 no 1207 0.381461950348731 1698 688787 SGTC_1789 tunicamycin 25 nM 0.30135976190096 0.365930677697948 no 1208 0.381570087110662 1895 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_453 enantio-paf c16 10 µM 0.30109863831693 0.366041400603928 no 1209 0.381669639670672 1787 13871343 A lipid and platelet activating factor SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.300449932166669 0.366316516443485 no 1210 0.381916990751327 1852 5282309 SGTC_947 3447-0010 211 µM 0.296733533570349 0.367893959308971 no 1211 0.383334976689271 1793 748350 SGTC_1670 st016595 4.04 µM 0.295486518977516 0.368423761663591 no 1212 0.383811124570968 1871 597879 SGTC_3274 9138298 49.47 µM 0.293017179934704 0.369473614200328 no 1213 0.384754510031617 1841 17015756 SGTC_1731 st035964 63 µM 0.292883156138423 0.369530623061741 no 1214 0.384805732021718 1737 6739575 SGTC_176 1486-1328 72.834 µM 0.292790365055634 0.369570094703085 no 1215 0.384841196632746 1733 22310231 SGTC_2924 9010168 62.78 µM 0.289640643514598 0.370910741804109 no 1216 0.386045585052679 1795 2993929 SGTC_837 0091-0265 12.5 µM 0.289476946410854 0.370980460836151 no 1217 0.386108209586141 1779 759367 SGTC_479 n-linoleoylglycine 10 µM 0.287735087294832 0.371722585159346 no 1218 0.386774764757364 1795 6433346 An anti-infammatory. SGTC_2175 5807670 165.306 µM 0.287665494830058 0.371752245165153 no 1219 0.386801402578007 1909 241186 SGTC_2254 7938975 95.19 µM 0.285701001975419 0.372589816911194 no 1220 0.387553568603755 1887 2969277 SGTC_601 0986-0029 62.9 µM 0.2848795238702 0.372940237361842 no 1221 0.387868221922971 1800 24747981 SGTC_1452 4194-0072 190 µM 0.283424139550386 0.373561323166008 no 1222 0.388425863006525 1946 1343545 SGTC_324 1315-0088 19.6 µM 0.283094053900549 0.373702233107108 no 1223 0.388552369769681 1847 6787421 SGTC_3127 9126946 49.47 µM 0.282359119374925 0.374016029211857 no 1224 0.388834079072772 1730 27243249 SGTC_3160 9100216 49.47 µM 0.282277072009845 0.374051066284642 no 1225 0.388865532451729 1908 17191039 SGTC_2271 7849410 118.62 µM 0.281882453543375 0.374219596599723 no 1226 0.389016822123464 1973 972430 SGTC_1366 1683-0113 21.9 µM 0.281678848130381 0.374306560080001 no 1227 0.3890948873854 1781 708623 SGTC_841 0251-0215 91.2 µM 0.281086307523082 0.374559681049967 no 1228 0.389322101493848 1864 3888614 SGTC_87 0100-0052 35.5 µM 0.281070231550116 0.374566549123591 no 1229 0.389328266473062 1866 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1827 berberine 7.24 µM 0.281050374535377 0.374575032611502 no 1230 0.38933588148346 1675 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2709 st078560 56 µM 0.280650294939629 0.374745971052707 no 1231 0.389489317940715 1924 17250903 SGTC_309 k408-0051 1.48 µM 0.280303578528491 0.374894129391445 no 1232 0.389622302761597 1820 3640463 SGTC_3336 9143619 71.43 µM 0.279658098667369 0.375170004054139 no 1233 0.389869914222254 1925 45595730 SGTC_3166 9102297 49.47 µM 0.279490501222347 0.375241644761443 no 1234 0.389934213314558 1763 25237072 SGTC_820 1582-0060 59.9 µM 0.279192608023789 0.375368991926675 no 1235 0.390048508064728 1795 3848840 SGTC_1055 3448-0672 86 µM 0.278975054933682 0.375462002865598 no 1236 0.39013198417494 1823 748378 SGTC_3186 9110464 49.47 µM 0.278916616000555 0.375486988621663 no 1237 0.390154408322806 1897 17018021 SGTC_2861 9024595 19.48 µM 0.278257957982994 0.375768636094063 no 1238 0.390407173390266 1930 16482810 SGTC_793 0488-0545 106 µM 0.277713558850788 0.376001475528194 no 1239 0.390616125710105 1770 292548 SGTC_1349 flufenamic acid 69 µM 0.276567180928154 0.37649192875396 no 1240 0.391056233926165 1799 3371 A non-steroidal anti-inflammatory. SGTC_904 1141-0088 396 µM 0.275899191671391 0.376777805666922 no 1241 0.391312747389979 1758 1378119 SGTC_39 0986-0283 58.349 µM 0.274116844089394 0.377540920756191 no 1242 0.391997414863394 1944 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_464 bw-b 70c 158 µM 0.273232851966486 0.377919581091196 no 1243 0.392337114099799 1916 5353454 SGTC_2291 7917025 104.35 µM 0.272438331523184 0.378260016126375 no 1244 0.392642501314886 1763 2964612 SGTC_2357 9067248 200 µM 0.271200796561277 0.378790461623762 no 1245 0.393118300181637 1845 9150235 SGTC_1931 st074438 57.1 µM 0.270133756537211 0.37924801116815 no 1246 0.393528676585593 1888 2787313 SGTC_82 0054-0107 293.755 µM 0.269313545264395 0.37959983495924 no 1247 0.393844204758396 1962 3104697 SGTC_2117 5521686 200 µM 0.269074611026109 0.379702342867314 no 1248 0.393936133809804 1777 803312 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.269034042773413 0.379719748356826 no 1249 0.393951742879854 1928 688662 SGTC_638 3970-0837 4.09 µM 0.268773611037046 0.379831490345931 no 1250 0.394051950838035 1799 4118451 YLR208W SEC13 SGTC_427 1354-0053 47.3 µM 0.268496105946628 0.379950568946254 no 1251 0.394158735937331 1921 6813657 SGTC_2316 5844804 197.44 µM 0.268494312129119 0.379951338717923 no 1252 0.394159426231572 1965 776813 SGTC_1806 st050005 60.3 µM 0.267769918759019 0.380262232760173 no 1253 0.39443821338634 1782 5194765 SGTC_1732 st034308 51.822 µM 0.267718340108658 0.380284372159701 no 1254 0.394458065804898 1769 830119 SGTC_651 3253-0966 34.4 µM 0.267525312333093 0.380367230057312 no 1255 0.39453236386466 1833 781462 SGTC_2661 dactinomycin 12.96 µM 0.264226085727154 0.381784281269038 no 1256 0.395802855805957 1856 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3116 9124943 49.47 µM 0.261431926700444 0.382985641852032 no 1257 0.396879719465277 1745 41905195 YPL160W CDC60 SGTC_306 1672-3436 11.6 µM 0.261322816107916 0.383032577343376 no 1258 0.39692178649868 1889 6797378 SGTC_1652 st011932 78 µM 0.260023603260014 0.383591584232854 no 1259 0.397422783441327 1933 1551076 SGTC_2745 rifampicin 24.3 µM 0.259589893379317 0.383778248792558 no 1260 0.397590066530021 1971 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_968 1309-0633 340 µM 0.259492574455498 0.383820137627544 no 1261 0.397627605293808 1960 3761976 SGTC_119 0121-0043 24.815 µM 0.258421124501018 0.384281409835515 no 1262 0.398040957572741 1952 1092378 SGTC_813 k007-0158 173 µM 0.258070564014031 0.38443236600334 no 1263 0.398176224392295 1925 6523916 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.257058155706792 0.384868421276153 no 1264 0.398566939613972 1821 5355888 SGTC_520 3584-0023 682 µM 0.254798378168289 0.385842256736057 no 1265 0.399439413987368 1797 1340790 SGTC_154 3389-1638 511.116 µM 0.254546925961283 0.385950662941584 no 1266 0.399536527965809 1722 5238686 SGTC_3041 9091929 49.47 µM 0.252371920088198 0.386888723460435 no 1267 0.40037680117381 1909 25236887 SGTC_2928 9011484 9.79 µM 0.25130683662764 0.387348325896714 no 1268 0.400788444939143 1850 2994751 SGTC_871 0574-0004 149 µM 0.250336586526829 0.387767143550127 no 1269 0.401163532516637 1858 9551173 SGTC_1567 st069303 68.4 µM 0.249527703912477 0.388116405254648 no 1270 0.401476306930894 1862 5581319 SGTC_1973 st070275 50.2 µM 0.249517093373926 0.388120987306099 no 1271 0.401480410177285 1980 17118334 SGTC_2714 st079313 56.9 µM 0.247172326290517 0.389133931661285 no 1272 0.402387430680663 1862 2939799 SGTC_1978 st071761 42 µM 0.246600715985343 0.389380983092527 no 1273 0.402608625190932 1817 5147680 SGTC_1702 st027038 51 µM 0.246227903218324 0.389542137820949 no 1274 0.402752908354718 1899 5521182 SGTC_2995 9067767 71.4286 µM 0.244629449595078 0.390233311884299 no 1275 0.403371679634312 1879 11673567 SGTC_172 1112-0046 2.638 µM 0.242598713184468 0.391111906145014 no 1276 0.404158139085336 1862 2802135 YIL048W NEO1 SGTC_753 1322-0200 289 µM 0.242488324749763 0.39115968146494 no 1277 0.40420090122643 1905 5403907 SGTC_555 4296-0685 37 µM 0.241888733327641 0.391419208986116 no 1278 0.404433190222929 1913 2908540 YHR072W ERG7 SGTC_2004 4023728 41.89 µM 0.241881678961497 0.391422262690266 no 1279 0.404435923370706 2009 360084 YDR527W RBA50 SGTC_2063 5246145 200 µM 0.240228549712569 0.392138055797772 no 1280 0.405076541066614 1930 711240 SGTC_2334 9017922 200 µM 0.238833887945831 0.392742218437235 no 1281 0.405617195863471 1975 3163164 SGTC_571 k831-0106 44.2 µM 0.238335527989419 0.392958169011716 no 1282 0.405810433893569 2012 4783639 SGTC_2321 7390090 138.78 µM 0.237797344857809 0.393191412865102 no 1283 0.406019139053286 1813 649046 SGTC_2308 7584454 197.62 µM 0.23761520460452 0.393270359543644 no 1284 0.406089778331733 1978 893577 SGTC_1470 k295-0292 231 µM 0.237454539849666 0.393340001548239 no 1285 0.406152091326269 1958 5045612 SGTC_2514 salinomycin 42.74 µM 0.237383641344418 0.393370734414487 no 1286 0.406179589701078 2021 23682228 A polyether potassium ionophore. SGTC_10 0279-0212 42.575 µM 0.236820364428945 0.393614925554724 no 1287 0.406398076181609 1916 39851 YBR002C RER2 SGTC_2201 6605497 169.863 µM 0.236241754487696 0.393865807420182 no 1288 0.406622540455131 1975 670741 SGTC_1640 st009078 66.4 µM 0.236065116294767 0.393942405483549 no 1289 0.40669107108357 1966 690618 SGTC_61 0978-8327 98.565 µM 0.235973054001755 0.39398232935606 no 1290 0.406726789785245 2039 6150059 YHR072W ERG7 SGTC_992 3909-8734 162 µM 0.235655003224748 0.394120264305616 no 1291 0.406850194384382 1850 4288319 SGTC_468 gf-109203x 121 µM 0.235168339486063 0.394331350453615 no 1292 0.40703903918927 2003 2396 A protein kinase C inhibitor. SGTC_953 1188-0045 9.7 µM 0.235049709305167 0.39438280996618 no 1293 0.407085075675919 1913 6144426 SGTC_1499 4480-0877 67.3 µM 0.23476851945345 0.39450479212875 no 1294 0.407194201371441 1979 2861909 SGTC_2876 9059903 25.97 µM 0.234286809993216 0.394713785163068 no 1295 0.407381162550671 1970 6916095 SGTC_1088 bifonazole 369 nM 0.233358592758031 0.395116584140375 no 1296 0.407741481892922 1961 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1772 st048439 82.2 µM 0.23306504846339 0.395243990757822 no 1297 0.407855447434216 1861 2927068 YDL195W SEC31 SGTC_1475 4092-1048 11.7 µM 0.2329487880989 0.395294454177236 no 1298 0.407900586476368 1903 2881759 SGTC_2863 9028737 58.44 µM 0.232596295791435 0.395447466036722 no 1299 0.408037451982008 2039 6460917 SGTC_378 3970-0959 8.33 µM 0.231237851193453 0.396037297931209 no 1300 0.408565012864549 1924 6615653 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.230099219464063 0.39653187133766 no 1301 0.409007335699906 1864 229346 A bile salt which induces apoptosis. SGTC_2458 5808907 16.39 µM 0.229228020937563 0.39691039558013 no 1302 0.409345847390387 2024 2731747 SGTC_205 1486-1330 71.903 µM 0.228642746167541 0.397164744307616 no 1303 0.409573298924233 1913 4118834 SGTC_256 clotrimazole 625 nM 0.228317874095758 0.397305946108362 no 1304 0.409699564990311 1927 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_355 1311-2252 105 µM 0.228302533485835 0.39731261405583 no 1305 0.409705527564196 1856 5338538 SGTC_2208 7283366 200 µM 0.227801999938406 0.397530192354447 no 1306 0.40990008592295 1999 898663 SGTC_261 5-fluorouridine 15.376 µM 0.22736402011 0.397720605164389 no 1307 0.410070347731288 1992 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.227303573659473 0.397746886322482 no 1308 0.410093847227823 1951 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2238 6671620 73.2395 µM 0.226911822958732 0.397917224559355 no 1309 0.410246154221218 1917 729941 SGTC_1267 0828-0272 9.49 µM 0.225616627998036 0.398480530329372 no 1310 0.410749803505947 2006 745334 SGTC_7 0192-1582 4.227 µM 0.223423365505987 0.399434905303055 no 1311 0.411603010427193 1943 252616 SGTC_995 3931-2021 34.6 µM 0.222597290982366 0.399794519084625 no 1312 0.411924472519626 1923 730143 SGTC_3151 9099821 49.47 µM 0.222172576604902 0.399979442465318 no 1313 0.412089770670823 1861 17174189 SGTC_84 0443-0269 128.823 µM 0.221626629220193 0.400217184425384 no 1314 0.412302275421491 2004 6150058 SGTC_2823 7987624 58.44 µM 0.220674031567427 0.400632097587191 no 1315 0.412673126405236 1922 2239440 SGTC_2020 4017018 200 µM 0.219947495352116 0.40094862290113 no 1316 0.412956022977102 1908 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3323 9138564 53.9225 µM 0.219742233976389 0.401038059582583 no 1317 0.413035955255282 2033 43912313 YNL103W MET4 SGTC_1203 3992-3522 103 µM 0.219614432125614 0.40109374814656 no 1318 0.413085725295691 2074 5322312 SGTC_3210 9128157 49.47 µM 0.219147063939863 0.401297416942016 no 1319 0.413267744983352 1776 17590849 SGTC_1141 3253-0389 52.6 µM 0.219016299789984 0.401354405892273 no 1320 0.413318675301743 2017 5402031 SGTC_2125 5246583 200 µM 0.217671347450743 0.401940677592262 no 1321 0.413842594902176 2074 835267 SGTC_703 3875-0075 71.8 µM 0.21694474334857 0.402257500006247 no 1322 0.414125703855611 1940 2850814 SGTC_1318 1280-3875 124 µM 0.216365543814408 0.402510095369698 no 1323 0.414351411096368 1953 373245 SGTC_796 1234-0020 70.7 µM 0.215030552464084 0.403092454835597 no 1324 0.414871749129277 1979 46495034 SGTC_92 0063-0024 660.874 µM 0.214090438496783 0.403502687170035 no 1325 0.415238265958226 2054 3594437 SGTC_2921 7974240 10.71 µM 0.213507580591388 0.403757079011954 no 1326 0.415465538488592 1964 2979074 YDR527W RBA50 SGTC_3016 9080866 49.47 µM 0.213198248208671 0.403892105538738 no 1327 0.415586167293319 1931 17066299 SGTC_2552 juarezic acid 87.02 µM 0.212286577357566 0.404290125097351 no 1328 0.415941733256578 2058 1549512 SGTC_756 0508-1999 28.3 µM 0.210126215685426 0.405233696138596 no 1329 0.416784582524378 1829 6753853 SGTC_2989 9073649 71.4286 µM 0.209326238891087 0.405583238367028 no 1330 0.417096784899663 2085 21367202 SGTC_681 1642-0006 26.6 µM 0.206583881209602 0.406782055307349 no 1331 0.418167424825885 2030 4446530 SGTC_1810 st050138 53 µM 0.206323685189868 0.406895845124009 no 1332 0.418269039215055 2050 3444541 SGTC_1847 st056231 15 µM 0.206230164330716 0.406936745907982 no 1333 0.418305563262785 1959 5393180 SGTC_1689 st020265 53.493 µM 0.205848234713599 0.407103791055797 no 1334 0.418454731045118 2053 5758320 YPR016C TIF6 SGTC_2437 5741531 144.16 µM 0.205802764027198 0.407123679766593 no 1335 0.418472491018913 2054 2262990 SGTC_945 3381-0768 11.3 µM 0.205751452926257 0.407146123340796 no 1336 0.418492532345658 2044 1126236 YIL048W NEO1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.205417551238209 0.407292180025188 no 1337 0.418622954374894 1903 61125 An anti-inflammatory. SGTC_208 k072-0098 12.366 µM 0.205205420703863 0.407384977755662 no 1338 0.418705817228514 2055 5948901 SGTC_3043 9092303 49.47 µM 0.204973307635464 0.407486522916717 no 1339 0.418796489832237 1873 25236084 SGTC_478 N-arachidonylglycine 10 µM 0.20463869734272 0.407632919650981 no 1340 0.418927209522602 2044 5283389 SGTC_1238 0333-0287 48.8 µM 0.204634851543363 0.407634602317599 no 1341 0.418928711984215 1938 7226 SGTC_3171 9103192 49.47 µM 0.202906017563152 0.408391197462469 no 1342 0.419604245392167 2075 13018434 SGTC_2721 ifenprodil 61.44 µM 0.20243539401666 0.408597217223724 no 1343 0.419788180360201 2033 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1958 st076513 41.9 µM 0.202291022297765 0.408660422329883 no 1344 0.419844609031557 1916 732122 YGL099W LSG1 SGTC_1713 st033146 12.748 µM 0.201949473448993 0.408809959902219 no 1345 0.419978112288672 2035 674619 SGTC_577 r071-0003 38.6 µM 0.20156520781497 0.408978215688196 no 1346 0.42012832352075 1975 4568517 YMR134W ERG29 SGTC_882 0843-0131 351 µM 0.201061454865392 0.409198815978244 no 1347 0.420325260523864 2069 5425421 SGTC_1288 0973-0013 65.5 µM 0.200918719679584 0.409261326895557 no 1348 0.42038106499669 1974 4315430 SGTC_610 4215-0184 155 µM 0.200043332661894 0.409644753314819 no 1349 0.420723345713485 1980 5605015 SGTC_503 tyrphostin 8 294 µM 0.199790626507912 0.40975545669706 no 1350 0.42082216624894 2056 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3295 9122362 53.5725 µM 0.198870207350633 0.41015872692591 no 1351 0.421182137545814 1897 4730473 SGTC_761 k216-0224 480 µM 0.198058039867721 0.410514646965641 no 1352 0.421499826894647 2100 1340404 SGTC_90 0870-0863 4.608 µM 0.197497940024231 0.41076014516059 no 1353 0.421718946658526 1913 1738164 SGTC_1649 st011737 51.3 µM 0.19600573608837 0.411414365692816 no 1354 0.422302838166981 1945 1761035 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.195252405520339 0.411744738873482 no 1355 0.422597677392702 2072 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1270 0831-1170 17.3 µM 0.193559365119538 0.412487449879262 no 1356 0.423260459157659 2023 6764716 SGTC_2569 tetrandrine 100 µM 0.191595054339135 0.413349555748374 no 1357 0.424029708405195 1884 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1447 4239-0816 81.9 µM 0.19057766997495 0.413796234697203 no 1358 0.424428243152713 1901 1341554 SGTC_2367 9070478 135.38 µM 0.189773161245546 0.414149530382941 no 1359 0.424743443958227 1949 572802 SGTC_2497 7-hydroxyflavone 100 µM 0.189398865823077 0.414313923907522 no 1360 0.424890106662001 2066 5281894 SGTC_2106 5357045 167.29 µM 0.189219837244264 0.414392559991626 no 1361 0.424960260316557 2030 668842 SGTC_3147 9097027 49.47 µM 0.187988044412566 0.414933702591323 no 1362 0.425443011636943 1996 25236841 SGTC_2223 6903751 107.57 µM 0.187877861600647 0.414982115214132 no 1363 0.425486198786271 2032 5598863 SGTC_1196 1588-0294 184 µM 0.18753444871346 0.415133013803273 no 1364 0.425620808305583 1945 6144269 SGTC_1282 0886-0010 32.4 µM 0.186744036918494 0.415480375110646 no 1365 0.425930663465642 2083 2836211 YNL267W PIK1 SGTC_2107 5363541 170.161 µM 0.18603811923064 0.415790659752201 no 1366 0.42620743413948 2073 244052 SGTC_1682 st012968 530 nM 0.185712468308564 0.415933816642785 no 1367 0.426335125060787 1901 24207270 SGTC_1460 k062-0059 9.15 µM 0.185029313916082 0.41623416910383 no 1368 0.426603021677859 1982 1373085 SGTC_2537 larixol 68.93 µM 0.184910697176268 0.41628632457384 no 1369 0.426649540273388 1990 6708759 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.184626806127683 0.41641115670892 no 1370 0.426760879568365 1945 6857784 SGTC_2926 9010726 65.15 µM 0.184457061660576 0.416485800513427 no 1371 0.426827454478009 1909 2994293 SGTC_861 0443-0273 110 µM 0.181744859728608 0.417678876881532 no 1372 0.427891479615032 2024 6149169 SGTC_2682 pyrogallin 40.03 µM 0.18096564337607 0.41802178872797 no 1373 0.42819727167156 2054 822798 An ATP competetive kinase inhibitor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.18055270455875 0.418203537114461 no 1374 0.428359340961642 1974 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1171 0368-0077 21.4 µM 0.1803967917294 0.418272164186249 no 1375 0.428420536419166 1964 3239779 SGTC_194 1486-1323 56.904 µM 0.179277482572158 0.418764915683011 no 1376 0.428859913354991 1943 5178754 SGTC_2749 bexarotene 57.39 µM 0.179051568340892 0.418864384992942 no 1377 0.42894860510906 1945 82146 An retinoic acid receptor inhibitor. SGTC_1353 1498-1206 8.11 µM 0.178994202122575 0.41888964398055 no 1378 0.428971127105899 2006 6756808 SGTC_3028 9087778 49.47 µM 0.178427912749737 0.41913900545136 no 1379 0.429193464904303 2001 17217395 SGTC_2217 6934799 96.0675 µM 0.178301457390069 0.419194693604044 no 1380 0.429243117161101 2096 675606 SGTC_102 gallobenzophenone 83.616 µM 0.177819597992631 0.419406908687459 no 1381 0.429432327830387 2087 70837 SGTC_1251 0490-5699 265 µM 0.177743241910208 0.41944053872591 no 1382 0.429462311894474 2106 3883818 SGTC_1779 st039427 55 µM 0.177372369895389 0.419603892823378 no 1383 0.429607954411195 2145 1124498 SGTC_1140 3229-1848 2.98 µM 0.177160154029303 0.419697371549121 no 1384 0.429691296508726 2104 2849525 SGTC_2228 7354201 200 µM 0.175700691312717 0.420340371094814 no 1385 0.430264546082619 2053 753451 SGTC_2905 7799065 20.05 µM 0.175634414886706 0.420369575744412 no 1386 0.430290581717983 2096 1296806 SGTC_2483 5729050 27.16 µM 0.17426936590598 0.420971180662747 no 1387 0.430826886648671 2096 2865180 SGTC_881 0833-0569 170 µM 0.173987187911083 0.421095565327436 no 1388 0.43093776561296 1900 5418700 SGTC_1488 4013-0813 75.9 µM 0.173633072223702 0.42125167142355 no 1389 0.431076919460978 1984 2910057 SGTC_2385 9074692 200 µM 0.173138046266309 0.421469916246502 no 1390 0.43127145996362 1953 17046906 SGTC_3300 9124615 50.48 µM 0.173133282580534 0.421472016556225 no 1391 0.43127333212799 2072 24824903 SGTC_1996 st072960 66.8 µM 0.172813716262497 0.421612918489716 no 1392 0.431398927620708 2114 1719405 SGTC_1453 4237-0541 195 µM 0.17257317841164 0.421718982121645 no 1393 0.431493468035446 2105 739892 SGTC_3002 9075603 71.4286 µM 0.172527023872198 0.421739334321212 no 1394 0.431511608952849 2115 20105405 SGTC_1747 st037496 66.6 µM 0.171232784429939 0.42231012409238 no 1395 0.432020364961176 2011 723305 SGTC_281 1672-3440 14.9 µM 0.170377712219923 0.422687320478679 no 1396 0.43235654946989 2084 6833000 SGTC_2495 cafestol 54.53 µM 0.170131890171858 0.422795772629979 no 1397 0.432453207183094 2038 16667697 An anti-infammatory. SGTC_2445 5742597 35.57 µM 0.168521251248186 0.423506501213591 no 1398 0.433086613333554 1981 1774255 SGTC_2722 naftopidil 47.16 µM 0.168251936685362 0.423625366332073 no 1399 0.433192541852417 2083 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1570 verbenone 133 µM 0.168097851064206 0.423693376941795 no 1400 0.433253149949405 2122 29025 A natural terpanoid with antifungal properties. SGTC_1179 1021-1431 9.29 µM 0.166919110331527 0.424213726871241 no 1401 0.433716848115708 2037 2840958 SGTC_818 4072-2707 53.5 µM 0.166574393262378 0.424365925722655 no 1402 0.433852471690191 2059 882871 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.164347012872266 0.425349625574177 no 1403 0.434728986941625 2030 2724278 An inhibitor of dopamine biosynthesis. SGTC_338 4055-0136 114 µM 0.16411542209358 0.425451932068082 no 1404 0.434820140673958 2037 2900563 SGTC_1959 st077091 55.8 µM 0.163942247455167 0.425528436192764 no 1405 0.434888304178131 2039 821356 YKL052C ASK1 SGTC_2736 butenafine 14.65 µM 0.160558058225136 0.427024043706928 no 1406 0.436220745453851 2111 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2738 aclarubicin 5.55 µM 0.160385107460752 0.427100505886788 no 1407 0.436288860140725 2086 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3111 9122088 49.47 µM 0.15755498231575 0.428352101874405 no 1408 0.43740373964977 2132 16876704 SGTC_2585 alliin 100 µM 0.157421603996078 0.428411105060009 no 1409 0.437456294100238 2062 87310 A garlic compound which reacts with lipids. SGTC_647 0140-0236 81 µM 0.157214723596706 0.428502626867072 no 1410 0.437537812422516 2064 990837 SGTC_2153 5569715 200 µM 0.156987216564174 0.428603278128437 no 1411 0.437627461441515 2105 2054701 SGTC_297 0986-0032 24 µM 0.156693516391385 0.428733220726932 no 1412 0.437743198564646 2032 2847425 SGTC_2304 7443016 91.4 µM 0.155162674095455 0.429410640378846 no 1413 0.438346536805279 2063 939854 SGTC_3085 9117376 49.47 µM 0.153216065449546 0.430272342654758 no 1414 0.439113944429819 2043 16480349 SGTC_3354 9151612 71.43 µM 0.152703443372142 0.430499319710582 no 1415 0.439316072598645 2129 27261949 SGTC_428 3448-4153 16.5 µM 0.152333363299848 0.430663196781207 no 1416 0.439462005935911 1907 3834874 SGTC_3200 9114385 49.47 µM 0.150727458309606 0.431374453850642 no 1417 0.440095356044014 2000 17018030 YLR208W SEC13 SGTC_2824 7998404 51.95 µM 0.150030791966092 0.43168307749215 no 1418 0.44037016086363 2057 837851 SGTC_1496 4469-0713 57.4 µM 0.149741178211786 0.431811388856079 no 1419 0.440484409456407 2119 746691 SGTC_3075 9116269 49.47 µM 0.149143779704955 0.432076084829037 no 1420 0.440720090488362 2055 17015205 YNL244C SUI1 SGTC_2634 4'-methoxyflavone 100 µM 0.148913920541186 0.432177939204782 no 1421 0.440810778344297 2005 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3203 9113543 49.47 µM 0.148603748441421 0.432315388707741 no 1422 0.440933157513754 2046 17018012 SGTC_251 melphalan 456.522 µM 0.147494732588333 0.432806904310799 no 1423 0.441370768523447 2086 460612 A DNA alkylator. SGTC_2103 5378138 10 µM 0.147384522807881 0.43285575495569 no 1424 0.44141426056154 2114 244142 SGTC_1989 st071868 50.2 µM 0.146865778963461 0.433085702686399 no 1425 0.441618981700658 2163 16414057 SGTC_2650 prasterone 100 µM 0.146311264178852 0.433331531941111 no 1426 0.441837837010611 2135 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3047 9092122 49.47 µM 0.146270589471644 0.433349564998108 no 1427 0.441853891160944 2023 17173831 SGTC_1397 3532-0190 20.1 µM 0.145670654532103 0.433615561153413 no 1428 0.442090694251938 2059 5322280 SGTC_2258 7960471 200 µM 0.145378811615591 0.433744967886364 no 1429 0.442205896405215 1993 2974708 SGTC_3080 9117754 49.47 µM 0.145353207993409 0.433756321185916 no 1430 0.442216003419448 2156 9550191 SGTC_3205 9113483 49.47 µM 0.143189709606171 0.43471586809531 no 1431 0.443070178310376 2128 17018033 SGTC_1234 0326-0494 15.5 µM 0.142901120315002 0.434843891365331 no 1432 0.443184136885647 2133 1547813 SGTC_603 3794-0023 45.9 µM 0.142729142963013 0.434920186783783 no 1433 0.443252049797636 2154 3802260 SGTC_2024 5144227 134 µM 0.141527950602015 0.435453146891947 no 1434 0.443726440440148 2117 3475211 SGTC_3141 9094609 49.47 µM 0.141519868829501 0.435456733112466 no 1435 0.443729632473657 1934 25236309 YDL196W YDL196W SGTC_270 tamoxifen 5.46 µM 0.141121922189098 0.435633325242646 no 1436 0.44388681277923 2170 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1221 2958-7315 257 µM 0.14105584633508 0.435662648195707 no 1437 0.443912912165915 2076 4562705 SGTC_588 3970-1144 52.9 µM 0.140725426865076 0.435809286104589 no 1438 0.444043428625394 2158 1888707 SGTC_2127 5253358 187.912 µM 0.140644287092269 0.43584529673322 no 1439 0.444075479953139 2051 20612 SGTC_2963 9082507 9 µM 0.140578405442043 0.43587453604837 no 1440 0.444101504381395 2093 16459611 SGTC_1834 st055981 52.8 µM 0.139802937578012 0.436218727214648 no 1441 0.444407846120349 2154 471719 YDL150W RPC53 SGTC_807 1315-0151 48 µM 0.139242133947887 0.436467669841635 no 1442 0.44462940735236 2185 4011080 SGTC_3084 9116877 49.47 µM 0.138809999277076 0.436659513055312 no 1443 0.444800146102827 2173 27241325 SGTC_2810 7959871 45.46 µM 0.138363163223507 0.436857898513678 no 1444 0.444976704219513 2115 2974535 SGTC_422 cantharidin 155 µM 0.138128905822437 0.436961910036744 no 1445 0.445069270598413 1998 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1148 3909-7663 27.7 µM 0.136937699182683 0.437490879344259 no 1446 0.44554001993558 2163 4084526 SGTC_2933 9026794 32.47 µM 0.136614992693507 0.43763420022947 no 1447 0.445667562581438 2110 17586027 SGTC_1005 4092-0690 4.4 µM 0.136359447899654 0.437747698969222 no 1448 0.445768565033679 2029 1529343 SGTC_1780 st038448 24.544 µM 0.135238900058565 0.438245444151054 no 1449 0.446211495898336 2118 728868 YDL195W SEC31 SGTC_1317 1273-0028 910 nM 0.135099840584293 0.438307220931396 no 1450 0.446266468109211 2071 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2003 4023581 200 µM 0.134139398902915 0.438733935415071 no 1451 0.446646172667246 2059 16641307 SGTC_472 calcifediol 10 µM 0.134045794398922 0.438775526762298 no 1452 0.446683181239047 2077 5283731 A vitamin D metabolite. SGTC_522 1273-0010 11.6 µM 0.133103600982892 0.439194209721549 no 1453 0.447055723658442 2088 5705015 SGTC_1722 st034304 3.6505 µM 0.131292752177145 0.439999088153705 no 1454 0.447771862543284 2067 4036148 YLR033W RSC58 SGTC_591 4299-0174 154 µM 0.129971695517093 0.440586422509213 no 1455 0.448294410206819 2107 5509088 SGTC_951 1171-0579 82.7 µM 0.129076598535944 0.440984451968225 no 1456 0.448648519375916 2162 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3197 9113331 49.47 µM 0.128788596066885 0.441112532874475 no 1457 0.448762464698775 2140 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1255 0566-0045 221 µM 0.128444480099553 0.441265576738426 no 1458 0.44889861631227 2088 2788469 SGTC_3033 9090887 49.47 µM 0.128438572494313 0.441268204193101 no 1459 0.448900953745456 2077 19325384 SGTC_2210 7115885 190.385 µM 0.128018299733789 0.44145513049064 no 1460 0.449067245553346 2134 2927039 SGTC_814 3342-0569 96 µM 0.127711814278969 0.441591455405182 no 1461 0.449188520108381 2177 4346283 SGTC_59 0330-0160 1.33 µM 0.127658442979155 0.441615195699271 no 1462 0.449209639314424 2115 4293482 SGTC_2522 biochanin a 4.94 µM 0.127630026251915 0.441627835939087 no 1463 0.449220883969378 2148 5280373 A possible chelator. SGTC_398 bronopol 33.3 µM 0.127189820634262 0.441823654412035 no 1464 0.44939508095239 2081 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_354 2783-3500 4.88 µM 0.127009769710969 0.441903751303663 no 1465 0.44946633303188 2019 6740761 SGTC_31 0508-1974 57.237 µM 0.126386293109719 0.442181127492543 no 1466 0.449713075830171 2154 6810525 SGTC_1914 st062367 72.6 µM 0.124995393171936 0.4428000217697 no 1467 0.450263598726577 2094 978205 SGTC_1458 k015-0034 6.33 µM 0.124951207023012 0.442819685116558 no 1468 0.450281089327929 2008 3598957 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.124832938180861 0.44287231681082 no 1469 0.45032790522413 2056 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2653 dihydrofissinolide 100 µM 0.122177041286794 0.444054500960449 no 1470 0.451379404310189 2119 6857746 SGTC_2659 sanguinarine 24.21 µM 0.121834099327052 0.444207186688664 no 1471 0.451515203873799 2132 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_961 1252-1571 372 µM 0.121822857851677 0.444212191794972 no 1472 0.45151965541545 2187 6813498 SGTC_1901 st060216 58.6 µM 0.119658407151724 0.445176047381627 no 1473 0.452376874917528 2197 688792 SGTC_1572 epiandrosterone 68.9 µM 0.11958417106684 0.445209111373953 no 1474 0.452406279695915 2104 441302 A steroid. SGTC_546 peri-Naphthalide 147 µM 0.119154869335941 0.445400325438823 no 1475 0.452576330446472 2151 223824 A penicillin ester. SGTC_898 1000-0849 28.3 µM 0.118691605445127 0.445606680741354 no 1476 0.452759843708968 2207 6751807 SGTC_3039 9090270 49.47 µM 0.118165665459037 0.445840972212474 no 1477 0.452968197154701 2229 17173750 SGTC_1590 st077108 57.8 µM 0.117693756403493 0.446051210524631 no 1478 0.453155157032643 2194 5489485 SGTC_2464 5717415 7.67 µM 0.117500848245241 0.446137156636102 no 1479 0.453231585949249 2125 5285744 SGTC_1672 st016598 6.51 µM 0.116238850894178 0.44669947486309 no 1480 0.453731623433729 2048 4665860 YNL267W PIK1 SGTC_1698 5-fluorocytosine 1.055 µM 0.116170455063627 0.446729953611079 no 1481 0.453758725814405 2200 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3304 9125678 46.087 µM 0.115975521938664 0.446816822000304 no 1482 0.453835970764811 2120 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_62 0180-0423 3.232 µM 0.114658610070493 0.447403746385147 no 1483 0.454357860934849 2153 30102 YGL099W LSG1 SGTC_1487 3970-0795 2.82 µM 0.11378202882307 0.447794487119879 no 1484 0.45470529249273 2135 3765103 SGTC_2772 vinpocetine 57.06 µM 0.113728326782617 0.44781842673976 no 1485 0.454726578338723 2174 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1936 st074407 74.3 µM 0.113271452386597 0.448022102645284 no 1486 0.454907674624287 2151 809813 SGTC_1200 1643-0193 18.4 µM 0.112754392555708 0.448252625916941 no 1487 0.455112638570256 2214 5403974 SGTC_1333 1482-0047 286 µM 0.112346517080421 0.448434483335731 no 1488 0.455274329969842 2233 3811116 SGTC_1402 3909-7673 35.9 µM 0.110417052786958 0.449294910270807 no 1489 0.456039314826039 2196 5328014 SGTC_3012 9080433 71.4286 µM 0.109966918103081 0.449495678169004 no 1490 0.456217805643503 2209 17688859 SGTC_2306 7482397 179.52 µM 0.108395217893329 0.450196784856551 no 1491 0.456841097177285 2192 891448 SGTC_1899 st063254 59.6 µM 0.107644186723721 0.4505318611378 no 1492 0.457138972336692 2140 3093813 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.107584083944133 0.45055867781803 no 1493 0.457162811438257 2111 4330530 SGTC_2132 5317594 122.667 µM 0.107001366917911 0.450818686398737 no 1494 0.457393947669331 2133 794577 SGTC_1406 3909-7906 11.9 µM 0.106648214583252 0.450976273396898 no 1495 0.457534033484524 2204 X1406 SGTC_250 brefeldin a 552.239 µM 0.105522622393897 0.451478597309785 no 1496 0.457980560062315 2182 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1502 4534-4282 27.7 µM 0.105504496057148 0.451486687282772 no 1497 0.457987751282483 2116 3278949 SGTC_558 k064-0027 21.3 µM 0.105285472571149 0.451584441338641 no 1498 0.458074645056083 2169 5088526 SGTC_3278 9139605 49.47 µM 0.104961467672071 0.451729055838217 no 1499 0.458203192060011 2173 7958859 SGTC_979 1426-2828 121 µM 0.103990009726849 0.452162689159287 no 1500 0.458588638334419 2159 747872 SGTC_1011 4112-3381 17.4 µM 0.103303033861782 0.452469371629344 no 1501 0.458861233915074 2154 2877139 SGTC_1410 3909-8106 77.9 µM 0.103039023932292 0.452587239534917 no 1502 0.458965999575182 2205 1039210 SGTC_2792 7535235 81.82 µM 0.102092480960633 0.453009860326385 no 1503 0.459341634577454 2102 1281891 SGTC_3262 9137218 49.47 µM 0.101946008202102 0.453075263533784 no 1504 0.459399765454273 2239 17650664 SGTC_1064 honokiol 6.76 µM 0.101145596539758 0.453432686832438 no 1505 0.459717441404454 2115 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1403 3909-7815 62.9 µM 0.101003197062549 0.453496279185937 no 1506 0.459773961134232 2144 6615483 SGTC_2922 7999257 32.47 µM 0.100827782889258 0.453574616787517 no 1507 0.459843585833552 2235 2988377 SGTC_560 2332-1943 155 µM 0.100480002019018 0.453729936367097 no 1508 0.459981629278903 2220 21177716 SGTC_318 1488-0629 67.2 µM 0.100384347368919 0.453772657152625 no 1509 0.46001959799143 2113 3662576 SGTC_2698 st077697 67.5 µM 0.100220730623701 0.453845732057567 no 1510 0.460084544107307 2117 3154499 SGTC_576 1073-0113 22.7 µM 0.100125428708322 0.453888296748904 no 1511 0.460122373790055 2254 5439563 SGTC_2110 5483698 200 µM 0.099273111785252 0.45426899052071 no 1512 0.460460713313211 2125 2848765 YHR062C RPP1 SGTC_3061 glucosamine 200 µM 0.0983528360926596 0.454680085752594 no 1513 0.460826062188928 2223 91431 and experimental redox chemotherapeutic SGTC_1341 1486-1360 280 µM 0.0982949286764933 0.454705955131855 no 1514 0.460849052506126 2182 3976547 SGTC_1483 3453-0561 55.9 µM 0.0975110463588477 0.455056163140954 no 1515 0.461160281155175 2205 4546991 SGTC_3353 9151644 39.2805 µM 0.0974917234422212 0.455064796307821 no 1516 0.461167953328953 2169 4909158 SGTC_454 lyso-paf C-16 6.67 µM 0.096836801526297 0.455357417358879 no 1517 0.461427998933656 2122 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3227 9130768 49.47 µM 0.0956385979081493 0.455892840866698 no 1518 0.461903804496521 2227 17720899 SGTC_967 1306-0166 352 µM 0.0951829966460238 0.456096449730716 no 1519 0.462084737687032 2240 4437607 SGTC_1667 st014849 34.6 µM 0.0944778564872083 0.456411600601575 no 1520 0.462364785859036 2230 5348460 SGTC_372 0155-0182 15.9 µM 0.0939344014922686 0.456654507651997 no 1521 0.462580633103159 2163 771486 SGTC_76 0433-0009 400.328 µM 0.0938369772756016 0.456698054884499 no 1522 0.462619328823789 2076 2841569 SGTC_2476 5806916 10.51 µM 0.0937336682611543 0.456744233105603 no 1523 0.462660362301376 2181 2870194 SGTC_1680 diphenhydramine 100 µM 0.0936804440354202 0.456768024094563 no 1524 0.462681502674367 2081 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0926769723151383 0.457216600337756 no 1525 0.46308009584575 2223 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2655 perillic acid 100 µM 0.0924385712679446 0.457323179434492 no 1526 0.463174797580809 2152 5702197 An apoptosis inducer. SGTC_2252 omeprazole 400 µM 0.092276609656159 0.457395587421083 no 1527 0.463239135928869 2188 4594 A proton pump inhibitor. SGTC_1006 4099-6547 255 µM 0.0911068462619917 0.457918594008033 no 1528 0.46370384636978 2193 3146833 SGTC_3284 9108171 64.8615 µM 0.0909694501345357 0.457980029247616 no 1529 0.463758432820068 2154 8687505 SGTC_1079 idarubicin 2.36 µM 0.090100687263599 0.458368510650731 no 1530 0.464103601542672 2258 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2789 5281112 71.43 µM 0.0887868665087789 0.458956082331268 no 1531 0.464625647736932 2160 765948 SGTC_2488 5268135 45.7 µM 0.0876787415432731 0.459451731764611 no 1532 0.4650660081657 2191 1270356 YLR208W SEC13 SGTC_1268 0828-0275 2.46 µM 0.0875447006494978 0.459511690746988 no 1533 0.465119277908359 2213 745337 SGTC_1424 4048-1941 275 µM 0.0869677332863217 0.45976978946531 no 1534 0.465348580004496 2245 X1424 SGTC_25 0118-0223 35.662 µM 0.086364456077302 0.460039675675284 no 1535 0.465588350633363 2240 5333628 SGTC_521 r062-0005 13.8 µM 0.0855680240385974 0.460396001127278 no 1536 0.465904909160433 2199 2832033 SGTC_797 k781-0471 270 µM 0.0844463377716439 0.460897899915989 no 1537 0.466350783308001 2198 23738129 SGTC_878 0828-0289 13.7 µM 0.0839410113930462 0.461124028726466 no 1538 0.466551666114059 2163 745350 YLR208W SEC13 SGTC_1158 4092-0494 91.8 µM 0.0824102422739076 0.461809109953111 no 1539 0.467160245799482 2205 1148199 SGTC_2951 9072950 58.06 µM 0.0822501928564643 0.461880745133669 no 1540 0.467223880247546 2273 16488155 SGTC_116 0155-0182 31.788 µM 0.0808631251193142 0.46250162273604 no 1541 0.467775402892847 2105 771486 SGTC_2320 7373003 200 µM 0.0808077307752903 0.462526420193571 no 1542 0.467797429954632 2181 5415828 SGTC_2465 5809242 33.21 µM 0.0807605911024057 0.462547522535536 no 1543 0.467816174698473 2262 2731748 SGTC_2171 5739187 198.077 µM 0.0802622986193433 0.462770592426824 no 1544 0.468014321391478 2241 2262761 SGTC_528 3492-0019 172 µM 0.0801940956415378 0.462801125669979 no 1545 0.468041443017329 2263 2869262 SGTC_2982 9019404 25.97 µM 0.0785365873073958 0.463543229217694 no 1546 0.468700613812728 2134 22333232 SGTC_903 1134-0042 114 µM 0.0781772707861167 0.463704120081643 no 1547 0.468843520978952 2179 701009 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0762736355569988 0.464556607676986 no 1548 0.469600700252938 2268 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2339 9000433 200 µM 0.0757910198726292 0.464772759066781 no 1549 0.469792680339747 2159 2988954 SGTC_263 alizarin 107.927 µM 0.0754440114778634 0.464928181800897 no 1550 0.469930721434588 2277 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1323 1348-1351 11.2 µM 0.0752712374450555 0.465005568128941 no 1551 0.469999452868765 2145 6989654 SGTC_3254 9136651 49.47 µM 0.0750474461340411 0.465105807310655 no 1552 0.470088480872749 2285 16454030 SGTC_803 4488-1585 147 µM 0.0743617318561829 0.465412961851809 no 1553 0.470361279009509 2255 747204 SGTC_1495 4469-0029 237 µM 0.074227980536605 0.465472875984194 no 1554 0.470414491005259 2253 793680 SGTC_2469 5655019 90.81 µM 0.0740565511630568 0.46554966920956 no 1555 0.470482693714808 2258 2788239 SGTC_202 3594-0513 34.79 µM 0.0729037154106146 0.466066124832784 no 1556 0.4709413686718 2283 708429 SGTC_3162 9099653 49.47 µM 0.0724057995548002 0.466289202469906 no 1557 0.471139484766978 2290 25237511 SGTC_2628 lathosterol 100 µM 0.0721855383417154 0.466387887890106 no 1558 0.471227126939812 2229 6710616 SGTC_1035 k081-0041 55.2 µM 0.0707836657839089 0.46701602841753 no 1559 0.471784966014597 2275 731709 SGTC_2696 st077691 74.316 µM 0.0699842934064213 0.467374242068541 no 1560 0.472103080514206 2235 757133 SGTC_408 cantharidin 100 µM 0.0696669938532308 0.467516437250218 no 1561 0.472229356508554 2188 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2767 sibutramine 71.45 µM 0.0696471523864865 0.467525329178035 no 1562 0.472237252928147 2262 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2015 5119600 184 µM 0.0691395006100313 0.467752838167985 no 1563 0.472439289650022 2261 2828786 SGTC_540 1187-0821 17.3 µM 0.0683741204229753 0.468095870494998 no 1564 0.472743911258949 2171 847520 SGTC_2543 pimpinellin 60.67 µM 0.0676560194700261 0.468417734499005 no 1565 0.473029730213033 2228 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2796 7949634 45.45 µM 0.0672584981913279 0.468595918603178 no 1566 0.473187957841595 2250 2971588 SGTC_2820 7989630 71.43 µM 0.0656126872458348 0.46933369999327 no 1567 0.473843093959835 2289 2984098 SGTC_1953 st076800 12.1 µM 0.0648798684970942 0.469662240796759 no 1568 0.474134824714617 2081 297591 SGTC_644 1498-1197 63.3 µM 0.063055053511439 0.470480439850245 no 1569 0.474861332568651 2259 6741615 SGTC_2541 muurolladie-3-one 83.07 µM 0.0629609111202777 0.470522654233352 no 1570 0.474898815471284 2258 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1363 1636-0063 10.4 µM 0.0620518304358554 0.470930312014133 no 1571 0.475260778386086 2291 6072185 SGTC_2173 5763948 167 µM 0.0614359076695585 0.471206526737376 no 1572 0.475506028085951 2298 2867177 SGTC_2085 5307070 144.047 µM 0.061322081807097 0.471257574234349 no 1573 0.475551352577289 2258 2840351 SGTC_2330 7979373 200 µM 0.0611148986233031 0.471350490910885 no 1574 0.475633851972376 2250 1863007 SGTC_2113 5491891 107.031 µM 0.061084404602411 0.471364166877854 no 1575 0.475645994640137 2245 789979 SGTC_1350 1495-0454 146 µM 0.0609970946346676 0.471403323863162 no 1576 0.475680761447294 2288 1069057 SGTC_2947 9072639 7.68 µM 0.0588984412740444 0.472344615304446 no 1577 0.476516499790645 2268 16488146 SGTC_2702 st077768 96.8 µM 0.0565227313078637 0.473410358766878 no 1578 0.477462693752258 2256 6484119 SGTC_2648 atorvastatin 78.68 µM 0.0552168327076952 0.473996266425984 no 1579 0.477982859416015 2303 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2950 9072895 21.46 µM 0.0550526888320907 0.474069915624359 no 1580 0.478048243893192 2244 17332245 SGTC_2595 hexamethylquercetagetin 100 µM 0.0547678250207591 0.474197732372474 no 1581 0.478161716913979 2265 386331 SGTC_1153 4055-0057 267 µM 0.0543209104671383 0.474398265700628 no 1582 0.47833974500198 2262 882706 SGTC_1993 st073995 70.8 µM 0.0531105329056348 0.474941402038005 no 1583 0.478821919626883 2224 3098394 SGTC_1222 0366-0074 1.18 µM 0.0517264298959393 0.475562551735264 no 1584 0.479373338706968 2308 286520 SGTC_1637 st007924 17.4 µM 0.0514177721179017 0.475701077530197 no 1585 0.479496311701024 2313 683336 SGTC_1384 3089-0840 101 µM 0.0512843949992878 0.47576093817038 no 1586 0.479549451363744 2306 1069836 SGTC_3031 9088762 49.47 µM 0.0509042397081201 0.475931557682212 no 1587 0.479700913546704 2312 205253 SGTC_3110 9122132 49.47 µM 0.0501694900009572 0.476261337074144 no 1588 0.47999366218872 2298 918317 SGTC_3334 9142812 21.919 µM 0.0500164850161906 0.476330012704564 no 1589 0.48005462580996 2291 45283678 SGTC_1289 0976-0073 69.1 µM 0.0496247426066971 0.476505847802643 no 1590 0.480210714585411 2288 3391136 SGTC_3125 9127534 49.47 µM 0.0491289808640712 0.47672837893515 no 1591 0.480408253948853 2332 1639235 SGTC_1240 0356-0016 42.1 µM 0.0483335440295895 0.477085439489907 no 1592 0.48072521075729 2274 4305613 SGTC_2356 9061756 188.97 µM 0.0476869391429325 0.477375705018065 no 1593 0.480982871657589 2311 20104043 SGTC_315 k915-0449 187 µM 0.0475470108493354 0.477438521408454 no 1594 0.481038631719716 2246 20970215 YNL149C PGA2 SGTC_1338 1486-1223 76 µM 0.0474255886170688 0.477493030541093 no 1595 0.481087017597317 2274 3444526 SGTC_1633 st005664 67.9 µM 0.0473939529078103 0.477507232581698 no 1596 0.481099624243453 2317 2063822 SGTC_1227 3909-8010 46.6 µM 0.0471757215486985 0.47760520273265 no 1597 0.481186588685 2262 15982272 SGTC_1896 st058441 89 µM 0.0470550954038387 0.477659355758597 no 1598 0.481234658170851 2175 688759 SGTC_2686 alizarin 95.37 µM 0.0469938306363247 0.477686859676675 no 1599 0.481259072268531 2272 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2572 astragaloside iv 100 µM 0.0457210255937184 0.47825829066186 no 1600 0.481766302665726 2257 45006101 An anti-inflammatory agent. SGTC_2080 5212524 12.4 µM 0.045418573394795 0.478394084419644 no 1601 0.481886838417552 2345 260183 SGTC_357 1325-0123 420 µM 0.0451570525955595 0.47851150298674 no 1602 0.481991063184683 2311 1098503 SGTC_192 3455-0609 60.9 µM 0.0450978639723677 0.478538077970942 no 1603 0.482014651997596 2275 3769639 SGTC_155 k072-0202 43.6 µM 0.0432604886570066 0.479363084390281 no 1604 0.482746943600892 2339 5857737 SGTC_3185 9108267 49.47 µM 0.0427944957786819 0.479572335704556 no 1605 0.48293267585204 2260 4910486 SGTC_3229 9132204 49.47 µM 0.042614917279028 0.479652975861524 no 1606 0.483004252011908 2297 17682924 SGTC_2588 indole-3-carbinol 100 µM 0.0421082382464198 0.479880505778124 no 1607 0.483206206413216 2327 3712 Induces cell cycle arrest. SGTC_292 k038-0015 474 µM 0.0418557570474921 0.479993887751293 no 1608 0.483306843113625 2311 46368540 SGTC_3299 9121982 43.1275 µM 0.0409249231260916 0.480411912143228 no 1609 0.483677874153547 2296 17594604 YPL160W CDC60 SGTC_353 1988-1175 58.3 µM 0.0403831150762284 0.480655240448799 no 1610 0.483893845742654 2292 2788357 SGTC_174 3553-0389 74.3 µM 0.040280853113132 0.480701167543865 no 1611 0.483934609195584 2308 738071 SGTC_383 2324-0395 7.37 µM 0.0396764463305174 0.480972619213812 no 1612 0.484175539996175 2312 3146421 SGTC_1606 st000094 49.2 µM 0.0393344142862907 0.481126236843309 no 1613 0.484311884602598 2337 1242210 SGTC_1884 5633444 25 µM 0.0385020093160295 0.481500108444822 no 1614 0.484643714735424 2305 5724239 SGTC_672 1441-0018 53.7 µM 0.0379275824292852 0.481758119656678 no 1615 0.484872710633897 2334 251141 SGTC_3195 9113082 49.47 µM 0.0375281699572033 0.481937525407 no 1616 0.485031939792131 2346 17018038 SGTC_2236 dapsone 200 µM 0.0369525380596733 0.482196090790047 no 1617 0.485261424505907 2348 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2419 paclitaxel 166.5 µM 0.0365258020828135 0.482387779155099 no 1618 0.485431552672942 2297 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2007 4011539 71.82 µM 0.0364357903931107 0.482428212624738 no 1619 0.4854674382546 2324 45595301 SGTC_1430 4049-0248 69.1 µM 0.0360147963991001 0.482617326542088 no 1620 0.48563528039397 2337 22774488 SGTC_970 1315-0089 19.5 µM 0.0357533142366718 0.482734788422402 no 1621 0.485739529543212 2341 6811083 YLR033W RSC58 SGTC_166 k072-0058 166.424 µM 0.033287583940563 0.483842505356039 no 1622 0.486722627427057 2354 5846229 SGTC_2885 9057732 51.95 µM 0.0330672538731133 0.483941493727057 no 1623 0.486810478042728 2310 6471414 SGTC_180 1486-1293 102.781 µM 0.0327263401119617 0.484094659055491 no 1624 0.486946409383063 2355 4140536 SGTC_1751 st044839 27.194 µM 0.0281783094865044 0.486138208458098 no 1625 0.488759968438202 2360 5291326 SGTC_2307 7538926 6.34 µM 0.0275307648763938 0.486429198085092 no 1626 0.48901820115949 2320 96582 SGTC_2159 5658611 73.75 µM 0.0271916028606939 0.486581611525666 no 1627 0.489153456588902 2368 793844 SGTC_602 3130-1533 38.1 µM 0.0264783182517594 0.486902155443915 no 1628 0.489437913532025 2349 720941 SGTC_693 4161-2696 114 µM 0.0262204168205191 0.487018056204601 no 1629 0.489540765606099 2339 805759 SGTC_2762 leflunomide 42.06 µM 0.0256664646161424 0.487267005713424 no 1630 0.489761686199771 2352 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_161 4065-0411 162.148 µM 0.024500408892138 0.487791054385935 no 1631 0.490226728782561 2329 1906281 YLR208W SEC13 SGTC_3302 9125395 16.351 µM 0.0224715849889522 0.488702897982748 no 1632 0.491035889084321 2310 17599668 SGTC_2717 st081029 62.2815 µM 0.0224413105326227 0.488716505127455 no 1633 0.491047963799992 2357 5292846 SGTC_2006 4011487 200 µM 0.0223898555332143 0.488739632100476 no 1634 0.491068486218313 2355 45595294 SGTC_450 aminopyrene 156 nM 0.0223605861603633 0.488752787534809 no 1635 0.491080160086034 2364 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2147 5545932 89.7195 µM 0.0219533178307739 0.488935839927843 no 1636 0.491242596763598 2345 797404 SGTC_2240 6690706 185.951 µM 0.0219225926681183 0.488949649872894 no 1637 0.491254851380785 2360 805876 SGTC_197 4544-0043 41.561 µM 0.0187544223050966 0.490373705823051 no 1638 0.492518506576128 2372 896523 SGTC_3064 1327-0027 10 µM 0.0184932538077576 0.490491103765805 no 1639 0.492622679664083 2338 16000455 YPR107C YTH1 SGTC_3258 9138477 49.47 µM 0.0178403899815629 0.490784576394241 no 1640 0.492883091667195 2373 4970355 SGTC_3044 9093193 49.47 µM 0.0160402766313036 0.491593781210439 no 1641 0.493601129858337 2362 25236277 SGTC_1836 st055642 81 µM 0.0157904115603014 0.491706105846623 no 1642 0.493700798975494 2374 8571 SGTC_2932 9016711 44.54 µM 0.0156763408809489 0.4917573855324 no 1643 0.493746300960308 2375 7117328 SGTC_618 k072-0232 33.2 µM 0.0156654799603984 0.49176226799131 no 1644 0.493750633308723 2359 5872756 YGL099W LSG1 SGTC_731 3966-0296 387 µM 0.0155026658253088 0.491835460215035 no 1645 0.49381557886406 2377 660956 SGTC_1381 2324-0066 62.1 µM 0.014598763951599 0.492241809399882 no 1646 0.494176142686048 2361 10885928 SGTC_2980 9014342 25.29 µM 0.0142287668713619 0.492408143973462 no 1647 0.494323734831717 2331 2996599 SGTC_286 k060-0067 22.9 µM 0.0139431351415907 0.492536552464058 no 1648 0.494437674100825 2373 5985051 SGTC_2878 9043973 25.97 µM 0.0136090473056969 0.492686745843485 no 1649 0.494570943216759 2359 6465167 SGTC_1734 st037168 69.4 µM 0.0130153859388665 0.492953636305846 no 1650 0.494807758848168 2329 708907 SGTC_2845 9003024 42.97 µM 0.0127560706637038 0.493070216850511 no 1651 0.494911202086777 2377 2990173 SGTC_3281 9140613 49.47 µM 0.0126472304273182 0.49311914840655 no 1652 0.494954619556405 2351 16013766 SGTC_3101 9120531 49.47 µM 0.0123054365296568 0.493272810146906 no 1653 0.4950909649806 2384 24824904 SGTC_1774 st048371 48.465 µM 0.0120738285487441 0.493376935703501 no 1654 0.495183356332119 2375 4242727 SGTC_2035 5154463 94.595 µM 0.0116966395253092 0.493546512070534 no 1655 0.49533382235268 2390 2769623 SGTC_2918 7977171 22.06 µM 0.0110040311562445 0.493857897452364 no 1656 0.495610115311338 2384 2236483 SGTC_925 2064-1272 59.6 µM 0.0100831194370521 0.494271930046189 no 1657 0.495977485499375 2375 6815817 SGTC_2394 5221648 200 µM 0.0100076328121096 0.494305868348887 no 1658 0.496007598786264 2371 788586 SGTC_3214 9129694 49.47 µM 0.00972202975346449 0.494434274024205 no 1659 0.49612153237753 2383 17158655 SGTC_2790 5423970 71.43 µM 0.00918398256674496 0.494676178845019 no 1660 0.49633617255631 2377 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_530 4358-1714 28 µM 0.00595734838201595 0.496126904376654 no 1661 0.497623375909072 2367 1564641 SGTC_1120 ficusin 1.78878 µM 0.00563668743279679 0.496271079713267 no 1662 0.49775129896937 2383 6199 A DNA cross-linker. SGTC_3182 9108849 49.47 µM 0.00538871157631773 0.496382574767678 no 1663 0.497850225519591 2387 17133045 SGTC_1253 0550-0034 176 µM 0.0053025655947589 0.496421307842528 no 1664 0.497884592302878 2385 5969915 SGTC_1131 3454-3128 32.3 µM 0.00404106227790845 0.496988510374901 no 1665 0.498387853787382 2386 710982 SGTC_988 1497-1057 103 µM 0.00309173192462772 0.49741535643718 no 1666 0.498766579380604 2400 3533044 SGTC_107 0358-0022 2.6945 µM 0.00155691139182839 0.498105461666253 no 1667 0.49937888246989 2398 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_471 1-acyl-paf 4 µM 0.00107366302048882 0.498322747121999 no 1668 0.499571670508516 2402 16759367 SGTC_3017 9080681 49.47 µM 0.000448400955751909 0.498603887655615 no 1669 0.499821113906173 2402 16451914 SGTC_567 1080-0542 68.4 µM 0.000422605752097912 0.498615486131902 no 1670 0.499831404702566 2405 5950415 SGTC_1373 2887-0003 58.5 µM -0.000466336507167013 0.499015188052236 no 1671 0.499813958657139 2408 776948 SGTC_2371 9071574 200 µM -0.00115014165655073 0.499322653295514 no 1672 0.499541159965912 2409 45596039 SGTC_1880 MG-132 525 µM -0.00126269768692111 0.499373262883632 no 1673 0.499496256639184 2408 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1324 1418-0026 34.4 µM -0.00167820394969268 0.49956009081163 no 1674 0.499330493803594 2417 1372513 SGTC_1669 st015249 58.4 µM -0.00178544896447793 0.499608312397892 no 1675 0.499287709297014 2408 722793 SGTC_2049 5262831 67.185 µM -0.0021594393194731 0.499776473244459 no 1676 0.499138509023049 2409 763417 SGTC_1906 st060206 94.7 µM -0.00227263934866983 0.499827372461317 no 1677 0.499093348856171 2408 5133468 SGTC_2186 6124449 200 µM -0.00236105315467876 0.49986712681247 no 1678 0.49905807694546 2406 3834182 YLR033W RSC58 SGTC_1966 st070145 16.1 µM -0.00295207392279427 0.49986712681247 no 1679 0.498822294607893 2408 3748532 SGTC_2029 5175081 200 µM -0.00330800749015923 0.499707084986466 no 1680 0.498680298355188 2412 1380876 SGTC_1068 loratadine 26.9 µM -0.00342940349502693 0.499652500545173 no 1681 0.498631868631 2415 3957 A H1 histamine antagonist. SGTC_1951 sophoraflavanone G 9.2 µM -0.00367074894441934 0.499543982113607 no 1682 0.498535586334015 2417 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1530 rhein 70.4 µM -0.00371894893581151 0.499522309500484 no 1683 0.498516357450791 2411 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_791 1348-1292 225 µM -0.00779281641567218 0.497690549877987 no 1684 0.49689114751414 2448 5437054 SGTC_3150 9097574 49.47 µM -0.0079761209515183 0.497608130318874 no 1685 0.496818021857662 2420 17217476 SGTC_2713 st079149 53.4 µM -0.00807850416857906 0.497562095606924 no 1686 0.496777178179549 2429 3103253 SGTC_2858 9025781 8.96 µM -0.00852729820456147 0.497360304095446 no 1687 0.496598141436245 2423 4894980 YPL153C RAD53 SGTC_2327 6189656 200 µM -0.00872994634323773 0.497269187518623 no 1688 0.496517299535343 2432 5349088 SGTC_2883 9059145 45.46 µM -0.00954067831366298 0.496904659998467 no 1689 0.496193877778814 2419 16476510 SGTC_3103 9120822 49.47 µM -0.00986736330214649 0.496757774104363 no 1690 0.496063555461357 2418 17141819 SGTC_2555 cholic acid 100 µM -0.010780607395417 0.496347158687441 no 1691 0.495699243208452 2494 6708657 Influences liver metabolism. SGTC_2889 9059656 51.95 µM -0.0110135680817078 0.496242414840679 no 1692 0.49560631085909 2430 3949838 SGTC_2460 5552655 174.22 µM -0.0117085053909867 0.495929958507065 no 1693 0.495329088881304 2458 5401989 SGTC_3187 9109394 49.47 µM -0.0117439384844144 0.495914027215203 no 1694 0.495314954094041 2443 17098090 SGTC_1705 st027868 56.3335 µM -0.0121015582316447 0.495753235962182 no 1695 0.495172294597346 2457 292948 SGTC_425 3825-7017 13.1 µM -0.0136409654545879 0.495061103372059 no 1696 0.494558210899529 2515 3397440 SGTC_2188 6126565 140.678 µM -0.0146944379510197 0.494587460244264 no 1697 0.494137978376337 2432 874518 SGTC_2030 5175110 200 µM -0.0151415244327384 0.494386451626026 no 1698 0.493959636523021 2452 2831986 SGTC_3325 9138760 55.175 µM -0.0153532227744104 0.494291273238894 no 1699 0.493875190920623 2441 43844959 SGTC_2421 5690543 90.72 µM -0.0154498045448049 0.494247850724216 no 1700 0.493836664938492 2428 3397993 SGTC_2944 9067346 25.62 µM -0.0159876332978621 0.494006047793344 no 1701 0.493622128817096 2442 6473075 SGTC_1723 st034307 2.5525 µM -0.0173620720977587 0.493388122785602 no 1702 0.493073883336462 2454 867466 SGTC_2627 acetyl isogambogic acid 100 µM -0.018362948951303 0.49293815496419 no 1703 0.492674654954606 2473 6857789 A caspase activator and apoptosis inducer. SGTC_2854 9024559 71.43 µM -0.0183709857327763 0.49293454187492 no 1704 0.492671449283433 2451 3163529 SGTC_16 erodoxin 22.806 µM -0.0184311405160564 0.492907498156655 no 1705 0.492647455059573 2453 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2134 5324836 1.464 µM -0.0185844506511458 0.49283857483935 no 1706 0.492586303638987 2459 699272 SGTC_1157 4092-0394 27.6 µM -0.0188618361076905 0.492713871783627 no 1707 0.492475662247464 2460 3659885 SGTC_2027 5150920 200 µM -0.0197750455394231 0.492303329016626 no 1708 0.492111412382699 2460 786715 SGTC_935 2996-0153 430 µM -0.0205119621957777 0.491972046417765 no 1709 0.49181748481618 2444 23738523 SGTC_2325 6158266 200 µM -0.0212484349733259 0.49164096889783 no 1710 0.491523738734572 2471 3623240 SGTC_1790 st045711 43.5 µM -0.021620438156975 0.491473738969445 no 1711 0.491375365024984 2456 585119 SGTC_3232 9132874 49.47 µM -0.0219636728051823 0.491319442947478 no 1712 0.491238466722317 2449 3784940 SGTC_1812 st052057 4.327 µM -0.0220002704741236 0.49130299108693 no 1713 0.491223869891885 2435 3645418 SGTC_2841 9004761 38.96 µM -0.0221218758718475 0.49124832555197 no 1714 0.49117536816135 2450 2991039 SGTC_1767 st044992 70.3 µM -0.0231119220588901 0.490803274176218 no 1715 0.490780497899659 2465 9600693 SGTC_2602 kawain 100 µM -0.0231576534319705 0.490782717013233 no 1716 0.490762258603055 2440 5369129 SGTC_1233 0325-0408 14.2 µM -0.0239081816447488 0.490445343172195 no 1717 0.490462924070307 2459 12874 SGTC_1974 st069448 26.9 µM -0.0244184412436552 0.490215977614322 no 1718 0.490259419362904 2449 6323587 YNR016C ACC1 SGTC_2081 5214970 32.255 µM -0.0251615702800933 0.489881941286654 no 1719 0.489963044858929 2456 2063512 SGTC_2711 st079103 59.1 µM -0.0260208207612942 0.489495717258427 no 1720 0.489620365753299 2482 54693780 SGTC_1587 estradiol valerate 56.1 µM -0.0268580530024601 0.489119399668035 no 1721 0.489286475146012 2465 13791 A steroid. SGTC_1855 st056195 39.6 µM -0.0287064768908857 0.48828860831288 no 1722 0.488549345342998 2469 4028379 SGTC_3240 9133527 49.47 µM -0.0292290708367849 0.488053732648253 no 1723 0.488340947979653 2455 17617455 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0295527846266424 0.487908244150287 no 1724 0.488211860629281 2463 147795 SGTC_505 gw-5074 63.9 µM -0.0313133739368839 0.48711700133143 no 1725 0.487509812389743 2539 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3255 9139072 49.47 µM -0.032052055734946 0.486785038395392 no 1726 0.487215268863104 2505 17646060 SGTC_1636 st007707 68.9 µM -0.0326347893912055 0.486523164863621 no 1727 0.486982913337692 2479 403051 SGTC_67 0335-0847 266 µM -0.0326591611040855 0.486512212633319 no 1728 0.486973195611056 2529 4552207 YOR254C SEC63 SGTC_2647 atorvastatin 60.16 µM -0.0330504757467172 0.486336363934471 no 1729 0.486817167890105 2496 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_926 2268-1401 59.4 µM -0.0347325759191078 0.485580493626149 no 1730 0.486146492381978 2461 2931578 SGTC_2338 7999974 200 µM -0.0352086938705755 0.485366554050337 no 1731 0.485956664912273 2521 315925 SGTC_1449 4112-4002 201 µM -0.0360980897662664 0.484966922855261 no 1732 0.485602072741245 2512 2059539 SGTC_77 0828-0286 12.516 µM -0.0362289054592198 0.484908144860353 no 1733 0.485549918944906 2469 745345 SGTC_846 0335-0850 148 µM -0.0379151596610796 0.48415050837883 no 1734 0.484877663039238 2476 6819598 SGTC_1111 tnp00062 510.699 nM -0.0381725898977366 0.484034849563167 no 1735 0.484775037527564 2530 676306 SGTC_2429 5902844 64.44 µM -0.0383217489506311 0.483967835674048 no 1736 0.48471557518295 2517 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_88 0180-0332 8.668 µM -0.0395045404125789 0.483436449615297 no 1737 0.484244066809249 2463 3101745 SGTC_1047 2043-3044 82 µM -0.0395081714632543 0.483434818358423 no 1738 0.484242619359608 2477 669592 SGTC_3060 1327-0027 12.5 µM -0.0397069724398174 0.483345507040761 no 1739 0.484163371429669 2490 16000455 YPR107C YTH1 SGTC_3290 9121031 71.43 µM -0.0397585043477001 0.483322356472804 no 1740 0.484142829393986 2497 17014854 SGTC_1852 st056254 31.4 µM -0.0399981668492113 0.483214689492897 no 1741 0.484047293883729 2530 442583 SGTC_971 1315-0384 26.7 µM -0.0410566494973461 0.482739187088953 no 1742 0.483625367065558 2494 6769120 SGTC_712 r015-0009 80.6 µM -0.0413080004216402 0.482626276237246 no 1743 0.483525177550837 2497 6813872 YLR060W FRS1 SGTC_2096 5468907 200 µM -0.0414147439526016 0.48257832575842 no 1744 0.483482629453625 2507 759785 SGTC_2100 5377183 190 µM -0.0420167588018264 0.482307898181063 no 1745 0.48324266916124 2533 2844202 SGTC_1768 st044301 37.178 µM -0.0428744929781777 0.48192261450803 no 1746 0.48290079085148 2506 3931349 SGTC_1122 capsaicin 818.572 nM -0.0430477206070878 0.481844804819096 no 1747 0.482831746771503 2566 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_236 1509-0011 5.31 µM -0.0431786554401151 0.481785992496709 no 1748 0.482779559854351 2490 3107280 SGTC_3077 9117319 49.47 µM -0.0432559188426916 0.481751288089201 no 1749 0.482748764988083 2480 17154678 SGTC_1263 0774-1208 64.8 µM -0.0433488334159916 0.481709553827501 no 1750 0.482711732172661 2495 906585 SGTC_2472 5377652 49.4 µM -0.0449554540844021 0.480987943176677 no 1751 0.482071407760516 2510 1610903 SGTC_2902 5787006 60.46 µM -0.0454939059584237 0.480746112350303 no 1752 0.481856816105961 2495 591003 SGTC_590 k048-0076 22.4 µM -0.0458556458718149 0.480583650806829 no 1753 0.481712653214483 2508 6832814 SGTC_789 1309-1135 70.6 µM -0.0459184251025738 0.480555456262008 no 1754 0.481687634279062 2496 3092424 SGTC_1624 st003710 6.25 µM -0.0461535615841786 0.480449855864436 no 1755 0.481593927744454 2479 24207033 SGTC_2204 7233102 200 µM -0.0462203322752625 0.480419869225438 no 1756 0.481567318489719 2479 2172480 SGTC_343 4130-2827 29.8 µM -0.0469538759348962 0.480090442961093 no 1757 0.481274994312201 2512 1118244 SGTC_187 1488-2104 32.728 µM -0.0470767113212647 0.480035280284108 no 1758 0.481226044213562 2548 2852859 SGTC_1256 0570-0116 285 µM -0.0510743803917182 0.478240229573393 no 1759 0.479633125413298 2512 410638 SGTC_2360 9040895 200 µM -0.0529768840311457 0.47738611189135 no 1760 0.478875162857384 2524 4914414 SGTC_1706 st031321 9.9705 µM -0.0538329777828957 0.477001807348535 no 1761 0.478534117566523 2510 6103185 SGTC_1019 4262-0212 3.4 µM -0.0546089139197516 0.476653504406938 no 1762 0.478225018538304 2507 4677213 SGTC_1770 st043884 66.3 µM -0.0546329014202161 0.476642737158052 no 1763 0.478215463174748 2509 670149 SGTC_2603 homopterocarpin 100 µM -0.0560964491153468 0.475985828309498 no 1764 0.477632486340838 2559 101795 A weak amylase inhibitor. SGTC_1007 4101-0031 70 µM -0.0562722881323005 0.475906907867933 no 1765 0.477562447355253 2503 1146276 SGTC_2703 st077852 53.4 µM -0.057069302912633 0.475549201895775 no 1766 0.477244994641412 2573 6281836 SGTC_690 glyoxal 20.3 µM -0.0571076558443769 0.475531989318495 no 1767 0.477229718948119 2519 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0577985951320059 0.475221907554639 no 1768 0.476954528616167 2518 803109 SGTC_3249 9135183 49.47 µM -0.0579726499961136 0.475143797060286 no 1769 0.47688520700872 2650 4902779 SGTC_451 chloral hydrate 100 µM -0.0591595586923892 0.474611174398406 no 1770 0.476412510342129 2595 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1096 rimcazole 32.2 µM -0.0612115877003616 0.473690438480768 no 1771 0.475595350694423 2500 18528119 A dopamine reuptake inhibitor. SGTC_3327 9140648 26.9345 µM -0.0618129208423603 0.473420649488436 no 1772 0.475355906910451 2528 8029710 SGTC_630 4356-0227 183 µM -0.0622233717339395 0.473236507089516 no 1773 0.475192475298786 2514 779312 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0633250959945714 0.472742264048124 no 1774 0.474753816075275 2519 1241132 A phosphatase inhibitor. SGTC_2687 chenodiol 100 µM -0.0634967636676671 0.472665256203257 no 1775 0.474685468132302 2559 5702181 A cholesterol synthesis inhibitor. SGTC_697 0508-1955 564 µM -0.0635124005588362 0.472658241751676 no 1776 0.474679242481447 2511 6243113 SGTC_373 0844-0104 25.9 µM -0.0637071059797324 0.472570900820669 no 1777 0.474601723244893 2540 5375804 SGTC_642 0335-0876 158 µM -0.0648202052141482 0.472071612366151 no 1778 0.474158576922939 2532 6812350 SGTC_467 ro 31-8220 72.8 µM -0.0651406856079378 0.471927866743885 no 1779 0.47403099338698 2539 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_85 0868-0259 160.055 µM -0.0657951320327147 0.471634338140931 no 1780 0.473770465957603 2596 83173 SGTC_320 4092-0846 5.34 µM -0.0677571551922916 0.47075443559584 no 1781 0.472989475271193 2623 1359356 SGTC_1518 st038567 90.8 µM -0.0678884364798295 0.470695565325112 no 1782 0.472937221934207 2512 77966 SGTC_768 0384-0033 77.3 µM -0.0680475375763738 0.470624220717676 no 1783 0.472873896220295 2540 3965305 YMR134W ERG29 SGTC_598 3937-0236 20.2 µM -0.0680677951686171 0.470615136812921 no 1784 0.47286583330498 2580 1379313 SGTC_27 0485-0001 32.618 µM -0.0689975304636212 0.470198241661071 no 1785 0.472495792610521 2513 2054479 SGTC_1969 st069479 40.1 µM -0.0697612630258334 0.469855806879835 no 1786 0.472191839827392 2576 3895485 SGTC_2761 levamisole 97.89 µM -0.0700312836324482 0.469734743057272 no 1787 0.472084380008909 2548 26879 An alkaline phosphatase inhibitor. SGTC_317 4495-0002 170 µM -0.0700645263046418 0.4697198388881 no 1788 0.47207115059774 2566 15991618 SGTC_1494 4358-1428 177 µM -0.0701457226583677 0.469683435128068 no 1789 0.47203883744207 2524 1564571 SGTC_162 k030-0015 37.8 µM -0.0706796509855829 0.469444058799512 no 1790 0.471826358243817 2573 1809920 YMR134W ERG29 SGTC_1653 st012112 65 µM -0.0707168602506525 0.469427377163507 no 1791 0.471811550946276 2583 720429 SGTC_2517 totarol 10 µM -0.0708745719563557 0.469356672539754 no 1792 0.471748790554648 2587 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2844 9010103 25.97 µM -0.0735159150038413 0.468172662495503 no 1793 0.470697790000732 2682 2480525 SGTC_170 4197-0004 226 µM -0.0737202955040308 0.468081058366693 no 1794 0.470616474626316 2615 218692 SGTC_892 0929-0076 29 µM -0.0738740685478517 0.468012137809001 no 1795 0.470555294877825 2539 5751038 SGTC_2781 5567276 71.43 µM -0.0742194481530911 0.467857343337333 no 1796 0.470417885570304 2636 2853274 SGTC_432 NS 1619 61.3 µM -0.0749052278986039 0.467550000551125 no 1797 0.470145058492004 2689 4552 A K+/calcium channel activator. SGTC_369 0957-0393 4.5 µM -0.0756016062687039 0.467237927622692 no 1798 0.469868029253127 2564 6997992 SGTC_910 3454-3003 490 µM -0.0759934992065122 0.46706231473141 no 1799 0.469712135062707 2525 820824 SGTC_3189 9110682 49.47 µM -0.0772364376802089 0.466505378607944 no 1800 0.469217727566549 2598 17122418 SGTC_2283 7944793 200 µM -0.0777438385750135 0.466278041100225 no 1801 0.469015910736104 2578 2970533 SGTC_1984 st072354 53.1 µM -0.0779939006082092 0.466166006555713 no 1802 0.468916452411955 2571 5762938 SGTC_1464 k208-0027 110 µM -0.078892861387224 0.465763270054909 no 1803 0.468558920666205 2548 X1464 SGTC_2235 salicylic acid 500 µM -0.0790763637269848 0.46568106487921 no 1804 0.468485941821613 2541 338 A COX inhibitor and kinase inhibitor. SGTC_3167 9103034 49.47 µM -0.0791406617934521 0.465652261048608 no 1805 0.468460370743579 2543 5127859 SGTC_1476 4112-3294 3.34 µM -0.0806091135669251 0.464994482830522 no 1806 0.467876409108036 2661 704369 SGTC_3346 9158254 43.5805 µM -0.0811691890925823 0.464743627724509 no 1807 0.467653701092022 2618 17639500 SGTC_1241 0364-0022 50.8 µM -0.0811902746806932 0.464734183865141 no 1808 0.467645316831745 2622 4563895 SGTC_1618 st003135 44.5 µM -0.0813234397755893 0.464674542050002 no 1809 0.467592366740193 2533 1270615 SGTC_631 k072-0230 41.5 µM -0.0814904710178061 0.464599733429675 no 1810 0.467525951351072 2632 5773147 SGTC_3132 9126706 49.47 µM -0.081920024092231 0.464407354378516 no 1811 0.467355155516758 2746 850858 SGTC_887 0885-0007 9.62 µM -0.0825396069045029 0.464129883537019 no 1812 0.467108812005837 2692 5719458 SGTC_3059 1327-0034 3 µM -0.0834287915941632 0.463731706067246 no 1813 0.466755297963154 2579 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_695 3505-6186 243 µM -0.0839312145566021 0.463506736781307 no 1814 0.466555560742781 2632 1819379 SGTC_2913 7966556 36.57 µM -0.0840854293469351 0.463437686559589 no 1815 0.46649425465558 2556 2976516 SGTC_2050 5263056 171 µM -0.0861271877718181 0.46252358657743 no 1816 0.465682655602668 2599 763468 YGL055W OLE1 SGTC_3279 9140807 49.47 µM -0.0862226119859819 0.462480869738259 no 1817 0.46564472793842 2544 45595718 SGTC_737 1950-0117 57.9 µM -0.0866753568933088 0.462278203485567 no 1818 0.465464782516519 2556 5393513 SGTC_495 decylubiquinone 155 µM -0.0873594949913474 0.461971975225429 no 1819 0.465192882278728 2609 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1407 3909-7909 12.3 µM -0.0876576145635909 0.461838540438983 no 1820 0.465074404284015 2568 4411780 SGTC_565 1418-0001 44.5 µM -0.0898784038271336 0.460844677675353 no 1821 0.46419192146596 2656 2862145 SGTC_2366 9070441 60.58 µM -0.0907845798317405 0.460439209500857 no 1822 0.463831881480358 2592 6837235 SGTC_676 falcarinol 140 µM -0.0940781210595138 0.458965865004418 no 1823 0.46252355007579 2599 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1588 farnesol 29.9 µM -0.0954860442819284 0.458336210340743 no 1824 0.461964387329503 2582 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3296 9122258 64.045 µM -0.0959985854023759 0.45810701639177 no 1825 0.461760848030173 2655 4730474 SGTC_962 1254-0300 21.5 µM -0.0964016819504138 0.457926772753119 no 1826 0.46160077817196 2563 7340576 SGTC_1283 0922-0125 16.4 µM -0.0970023231684347 0.457658213559129 no 1827 0.461362274765155 2652 3360884 SGTC_757 1066-0008 322 µM -0.0973286871700302 0.457512297517104 no 1828 0.461232687538088 2745 6842497 SGTC_3102 9121669 49.47 µM -0.0981360425223195 0.457151356811145 no 1829 0.46091213392526 2608 41905072 SGTC_1208 2323-2347 50.3 µM -0.0987176186715966 0.456891376074402 no 1830 0.460681239759439 2609 5412760 SGTC_2061 5245884 80.95 µM -0.0991999284178007 0.456675784174629 no 1831 0.460489765846898 2598 573863 SGTC_2199 6590217 200 µM -0.0993154072557875 0.456624167157094 no 1832 0.460443922837687 2615 703109 SGTC_1819 st053448 58.6 µM -0.0997278119346493 0.456439835470568 no 1833 0.460280209938022 2598 2857616 SGTC_3220 9131269 49.47 µM -0.0997963664779829 0.456409194692323 no 1834 0.460252996390748 2555 17722206 SGTC_2212 7123476 200 µM -0.10106197085176 0.4558435735679 no 1835 0.459750633150255 2604 1085715 SGTC_3137 9097352 49.47 µM -0.101193683848701 0.455784713805977 no 1836 0.459698355270248 2767 44120435 SGTC_1127 asiatic acid 681.4 nM -0.102191752823856 0.455338729447804 no 1837 0.459302236889231 2594 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1961 st076550 68.7 µM -0.102834716421916 0.455051452714327 no 1838 0.459047075797471 2691 1579337 SGTC_3081 9117243 49.47 µM -0.102912703411036 0.45501660965047 no 1839 0.45901612768617 2757 45595589 SGTC_337 1315-0038 354 µM -0.104003727389462 0.454529197848058 no 1840 0.458583195292741 2626 1626437 SGTC_3217 9129673 49.47 µM -0.104418108187811 0.454344092325207 no 1841 0.458418776488704 2705 17248312 SGTC_2318 6029776 164 µM -0.10449092153777 0.454311567340148 no 1842 0.458389886202801 2679 818325 SGTC_1471 k673-0312 37 µM -0.105133593560801 0.454024505574144 no 1843 0.458134901598979 2588 24099884 SGTC_989 1501-0895 10.3 µM -0.105689749019052 0.453776107466413 no 1844 0.457914256946487 2574 2830112 SGTC_3014 9081533 49.47 µM -0.106658465731423 0.453343488579701 no 1845 0.457529967061637 2657 21367265 SGTC_1097 itavastatin 7.23 µM -0.107538902159296 0.452950342769128 no 1846 0.457180732394082 2608 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_424 splitomicin 100 mM -0.109706865166537 0.451982468458135 no 1847 0.456320927834453 2700 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_891 0929-0073 133 µM -0.10985429417577 0.451916659941797 no 1848 0.45626246552027 2755 5603632 SGTC_3212 9128307 49.47 µM -0.110466379916868 0.451643454765088 no 1849 0.456019755797211 2624 27243542 SGTC_1198 1612-1005 86.7 µM -0.110495073880758 0.45163064774215 no 1850 0.456008378211498 2764 6998509 SGTC_2256 7954252 200 µM -0.110617252920932 0.45157611593882 no 1851 0.455959932799177 2680 2972920 SGTC_3096 9117468 49.47 µM -0.110651303020805 0.451560918622974 no 1852 0.455946431654662 2606 41316311 SGTC_2062 5245942 200 µM -0.112755522443529 0.450621897372765 no 1853 0.455112190666553 2581 1376160 SGTC_2174 5790901 200 µM -0.113164467512855 0.45043943495011 no 1854 0.454950082740781 2669 786020 SGTC_2496 diffractaic acid 79.83 µM -0.114332149955518 0.449918498146335 no 1855 0.454487248806269 2739 94870 An apoptosis inducer which activates caspases. SGTC_1161 k007-0610 110 µM -0.114795472714465 0.449711820366936 no 1856 0.454303618792353 2657 5843850 SGTC_632 0781-2353 4.65 µM -0.115670546018455 0.449321507258504 no 1857 0.45395682519907 2686 6811515 YHR007C ERG11 SGTC_709 3807-1509 243 µM -0.115838981234496 0.449246384913383 no 1858 0.453890077949979 2586 1886677 YPL242C IQG1 SGTC_933 2914-0560 114 µM -0.1173132476605 0.448588937938065 no 1859 0.453305913702486 2734 463887 SGTC_2508 celastrol 40.54 µM -0.117531438551065 0.448491647975115 no 1860 0.453219466159896 2586 122724 Celastrol is a natural product and antioxidant. SGTC_1714 st033236 13.627 µM -0.117831153006619 0.448358012211989 no 1861 0.453100722479237 2730 2916566 SGTC_79 0052-0007 94.094 µM -0.118489809084849 0.44806435326787 no 1862 0.452839784692667 2699 2801472 SGTC_2897 9048598 12.99 µM -0.118499388357606 0.448060082600403 no 1863 0.452835989851114 2632 6467404 SGTC_2540 epiandrosterone 100 µM -0.120033231094306 0.447376337044336 no 1864 0.452228411826791 2641 441302 A steroid. SGTC_135 0933-0004 26.348 µM -0.121184616315345 0.446863183319245 no 1865 0.451772404356026 2710 21230617 YGL099W LSG1 SGTC_3267 9137951 49.47 µM -0.12133117346486 0.446797871538117 no 1866 0.451714364776766 2597 16643986 SGTC_1380 2291-0730 164 µM -0.122001396846275 0.446499211362827 no 1867 0.451448956006239 2687 2999191 SGTC_1445 4239-0156 97.7 µM -0.12279843546737 0.446144080197083 no 1868 0.451133356600288 2803 4008346 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.122850223098844 0.446121007020102 no 1869 0.451112851576788 2816 165506 SGTC_919 tnp00227 403.569 nM -0.124123163415961 0.44555392572658 no 1870 0.450608879112407 2682 1269246 A methoxyflavone. YNL221C POP1 SGTC_2877 9040724 71.43 µM -0.125872100948511 0.444774974626052 no 1871 0.449916583606864 2735 6463895 SGTC_1883 5-benzylidenerhodanine 20 µM -0.127680088176586 0.443969947818485 no 1872 0.449201074218354 2718 1273210 SGTC_1286 0929-0070 131 µM -0.12927379599505 0.443260522897891 no 1873 0.448570502597876 2738 1420408 SGTC_2343 7990716 14.84 µM -0.129305964522123 0.443246205227543 no 1874 0.448557776025959 2657 6456862 SGTC_3231 9132313 49.47 µM -0.129719490476165 0.44306215838587 no 1875 0.44839418084529 2682 4905967 SGTC_2412 st077135 33.4 µM -0.129847496224877 0.443005189712683 no 1876 0.448343542213289 2928 13258915 SGTC_1831 st055328 12 µM -0.131638338180371 0.442208303566587 no 1877 0.447635179949611 2676 1103068 SGTC_2641 levomentholum 100 µM -0.131939401635147 0.442074359674381 no 1878 0.447516111520105 2638 16666 SGTC_1554 st069299 38.7 µM -0.131999580899754 0.442047586561106 no 1879 0.447492311620924 2708 24207999 SGTC_634 1611-4317 11.2 µM -0.133388428012418 0.441429777086512 no 1880 0.446943098367933 2625 2843522 SGTC_1218 1348-1416 30.7 µM -0.133809520694335 0.441242487897612 no 1881 0.44677659923978 2621 6787668 SGTC_1746 st038117 42 µM -0.134190635159829 0.441072991126715 no 1882 0.446625915498054 2745 2898218 SGTC_2163 5671233 125 µM -0.13483619780952 0.440785908364906 no 1883 0.446370692725463 2701 701023 SGTC_1025 k007-0731 70 µM -0.134880056326109 0.440766405538294 no 1884 0.446353354094244 2644 6256118 SGTC_303 1348-1668 34.2 µM -0.13575787509809 0.440376090936782 no 1885 0.446006346735554 2688 5380509 SGTC_446 go6976 132 µM -0.136134165000608 0.44020879456914 no 1886 0.445857609584019 2727 3501 A protein kinase C inhibitor. SGTC_873 0591-4978 488 µM -0.136358019577004 0.440109275149172 no 1887 0.445769129579007 2847 3305145 SGTC_606 k015-0008 38.6 µM -0.136455337780545 0.440066011405102 no 1888 0.445730664756063 2748 1970475 SGTC_504 lovastatin 124 µM -0.13768182680666 0.439520825412546 no 1889 0.445245941353863 2662 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3291 9121177 71.43 µM -0.139582814218949 0.438676045487607 no 1890 0.444494809971408 2684 17015612 SGTC_2273 7815444 169.05 µM -0.140284652656762 0.438364225845096 no 1891 0.444217544908689 2778 2824616 SGTC_2305 7443522 69.23 µM -0.140617779872395 0.438216234206749 no 1892 0.444085950749329 2677 5415886 SGTC_689 0833-0039 98 µM -0.141392609881434 0.437872049723845 no 1893 0.443779896040834 2721 5374726 SGTC_1339 1486-1321 22.7 µM -0.141961050250949 0.43761957472059 no 1894 0.443555385713348 2676 3469382 SGTC_177 1327-0068 8.361 µM -0.142084851387463 0.437564591328049 no 1895 0.443506491808311 2636 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2397 5161689 200 µM -0.142285445465649 0.437475504698076 no 1896 0.443427271196784 2812 2259942 SGTC_2051 5263410 176 µM -0.142905849788919 0.437199994559501 no 1897 0.443182269265937 2641 227584 SGTC_1417 3966-0327 90.4 µM -0.143036353599552 0.437142044091719 no 1898 0.443130735176231 2695 651118 SGTC_1631 benzylvanillin 81.9 µM -0.143495396896514 0.436938215756939 no 1899 0.442949473187332 2780 75506 SGTC_2041 5107442 45.335 µM -0.14355802284212 0.436910409344827 no 1900 0.442924745064622 2727 793005 SGTC_607 4491-0986 66.8 µM -0.143937222702201 0.436742048288521 no 1901 0.442775021128468 2771 698981 YDR232W HEM1 SGTC_2142 5622915 118.518 µM -0.144343181568443 0.43656181919278 no 1902 0.442614740677253 2688 5322196 SGTC_2094 5332512 191.667 µM -0.145080147664172 0.43623467013234 no 1903 0.442323796156183 2789 755774 SGTC_1740 st038286 13.222 µM -0.145323874376359 0.43612648618718 no 1904 0.442227582893111 2844 716786 SGTC_2363 9053361 176 µM -0.146442261960391 0.43563012443548 no 1905 0.441786133340068 2799 6469797 YMR079W SEC14 SGTC_1866 st057638 64 µM -0.146727693371634 0.435503460737194 no 1906 0.441673479512364 2689 688802 SGTC_863 0466-0191 129 µM -0.146945614037605 0.435406760215685 no 1907 0.441587473944013 2667 765160 YPR165W RHO1 SGTC_2581 avocatin a 64 µM -0.1470649564894 0.435353804610672 no 1908 0.441540374872122 2727 6710728 A skin care supplement. SGTC_2484 5809818 12.04 µM -0.147161663382418 0.435310893890515 no 1909 0.441502209638528 2724 2870548 SGTC_615 k087-0205 167 µM -0.147621723846303 0.435106766598615 no 1910 0.441320654894799 2683 9642773 SGTC_1383 3049-0032 20.7 µM -0.147890813258373 0.434987380536793 no 1911 0.441214469219274 2812 712864 SGTC_1784 st039334 36.3 µM -0.14836548126224 0.434776800515979 no 1912 0.441027170250434 2906 3496984 SGTC_1467 k284-1082 293 µM -0.148388548262007 0.434766567625344 no 1913 0.441018068592276 2758 3334705 SGTC_3067 9117431 49.47 µM -0.151760202562084 0.433271321252927 no 1914 0.43968803611776 2723 17150885 SGTC_2737 bleomycin 30.5 nM -0.151798571214729 0.433254311145646 no 1915 0.439672904540578 2694 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1833 st055984 71 µM -0.153205826648933 0.432630513423143 no 1916 0.439117981459342 2719 676288 SGTC_3218 9131285 49.47 µM -0.153340572273096 0.432570793166742 no 1917 0.439064853471641 2751 17156417 SGTC_1816 st051957 91.6 µM -0.154611264480155 0.432007688927946 no 1918 0.438563894509773 2690 674121 SGTC_1049 3226-0134 66 µM -0.154825861758399 0.431912604253116 no 1919 0.438479301156651 2640 5702385 SGTC_3117 9124945 49.47 µM -0.154926074143261 0.431868203074043 no 1920 0.438439798814462 2651 17592065 SGTC_1271 0832-2808 169 µM -0.154985020179342 0.431842086210108 no 1921 0.438416563385168 2807 3663794 SGTC_2014 4013930 200 µM -0.155404708373873 0.43165614611598 no 1922 0.438251136258057 2679 64556 SGTC_1905 st060207 84.5 µM -0.155704771741561 0.431523214295019 no 1923 0.43813286787169 2668 1948547 SGTC_1865 st057639 52.2 µM -0.15589396182032 0.431439404711452 no 1924 0.438058302444194 2656 688818 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.156909442769482 0.43098960818922 no 1925 0.437658108896456 2809 521171 SGTC_1619 st003326 88.7 µM -0.159781299375307 0.4297180360585 no 1926 0.436526677871717 2856 2849032 SGTC_488 nitrendipine 139 µM -0.160255849650381 0.42950798920935 no 1927 0.436339768089615 2678 4507 Dihydropyridine L-type calcium channel blocker. SGTC_109 0132-0036 33.701 µM -0.160409504485937 0.429439982324406 no 1928 0.436279251535975 2656 67274 A color developer. SGTC_509 pifithrin 175 µM -0.16089760041424 0.429223967334284 no 1929 0.436087026137074 2694 4817 A p53 inhibitor. SGTC_1061 3448-9325 110 µM -0.162561909788541 0.428487559193031 no 1930 0.43543168978155 2645 723482 SGTC_1003 4049-0218 100 µM -0.164047336552817 0.42783051151258 no 1931 0.434846939684965 2856 295161 SGTC_983 1491-0821 12.2 µM -0.165020933218303 0.427399969673216 no 1932 0.434463752806184 2844 46495113 SGTC_3008 9078912 71.4286 µM -0.165561757701262 0.42716084474047 no 1933 0.434250922399471 2730 16648731 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.165776457413576 0.427065922921582 no 1934 0.434166437002437 2777 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2211 7117706 200 µM -0.167297268258603 0.426393671865936 no 1935 0.43356807673166 2747 822771 SGTC_1108 betulinic acid 729.144 nM -0.168298512178012 0.425951203971541 no 1936 0.433174222139565 2727 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2227 7312221 64.1025 µM -0.168831249774242 0.425715815496859 no 1937 0.432964688691358 2721 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3 0833-0587 95.581 µM -0.17021786206977 0.425103269415714 no 1938 0.432419402403634 2729 5382644 SGTC_2914 7968218 45.32 µM -0.170595243293735 0.424936589743908 no 1939 0.43227101919943 2807 2977111 SGTC_2747 doxorubicin 7.63 µM -0.170597499714105 0.424935593180846 no 1940 0.432270132022142 2689 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2884 9058502 51.95 µM -0.170682525002912 0.424898041546272 no 1941 0.432236702106159 2802 6471554 SGTC_2018 5133068 143 µM -0.171213245394307 0.4246636629545 no 1942 0.432028046478518 2698 785362 SGTC_1116 jasmonic acid  1.58368 µM -0.171432609040447 0.424566794589827 no 1943 0.431941807994398 2853 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_322 k048-0136 19.3 µM -0.171478440359868 0.42454655660202 no 1944 0.431923790725958 2789 6823282 SGTC_2369 9071472 200 µM -0.17281745908377 0.423955366756096 no 1945 0.43139745658233 2856 17296037 SGTC_663 1486-0733 13.9 µM -0.175107892647524 0.422944515297246 no 1946 0.430497428328204 2720 722445 YPR165W RHO1 SGTC_1382 3002-2117 298 µM -0.175447640209201 0.422794615397586 no 1947 0.430363954796924 2813 1497314 SGTC_24 0417-1663 219 µM -0.175809326761681 0.422635048088419 no 1948 0.430221871037469 2791 4329390 SGTC_3063 1327-0034 4 µM -0.175902212818684 0.42259407106704 no 1949 0.430185383440673 2731 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2285 7945142 200 µM -0.175999477330913 0.422551163372041 no 1950 0.430147176533556 2839 2970608 SGTC_237 nikkomycin 200 µM -0.177547484492449 0.421868392712285 no 1951 0.429539185205532 2856 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2821 7996764 71.43 µM -0.178388601858865 0.421497504200972 no 1952 0.429208900068804 2910 2987135 SGTC_3208 9114115 49.47 µM -0.178444171848074 0.421473003207708 no 1953 0.429187080907203 2804 650895 SGTC_2568 diosmetin 100 µM -0.178771555106449 0.42132866501389 no 1954 0.429058540590142 2758 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1867 st057372 64 µM -0.178825812099983 0.421304744968795 no 1955 0.429037238421553 2735 688837 SGTC_2446 5162541 200 µM -0.17886240316216 0.421288613390112 no 1956 0.42902287229853 2702 1549321 SGTC_568 1193-0097 7.48 µM -0.179108296594691 0.421180211950921 no 1957 0.428926333804796 2772 3646150 SGTC_579 4491-1009 110 µM -0.179150043303279 0.42116180862303 no 1958 0.428909944344736 2741 1271041 SGTC_3263 9137018 49.47 µM -0.180251872325976 0.420676148387191 no 1959 0.428477418523624 2751 43844957 SGTC_3313 9133968 57.047 µM -0.181909744113442 0.419945625299124 no 1960 0.427826778695597 2699 1494643 SGTC_2499 avocadenofuran 51.48 µM -0.185239940188392 0.418479046470211 no 1961 0.426520421701718 2715 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_830 4076-0286 57.8 µM -0.186360183317547 0.417985958228447 no 1962 0.426081157259774 2752 6866659 SGTC_2390 9097792 176.6 µM -0.186515934678589 0.417917412616059 no 1963 0.42602009202061 2745 4497149 SGTC_1985 st071382 65.5 µM -0.186934430876303 0.417733246304896 no 1964 0.425856021536412 2742 6123237 SGTC_2635 hydroquinidine 100 µM -0.187628145197295 0.417428005374061 no 1965 0.425584080696706 2738 442912 An experimental heart treatment. SGTC_1743 st037606 46.3785 µM -0.188205265233485 0.417174104946231 no 1966 0.425357872592824 2757 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_439 amiodarone 34.4 µM -0.188274207077026 0.417143776711288 no 1967 0.425330851773108 2803 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2457 5731572 11.68 µM -0.188419783596258 0.417079737704266 no 1968 0.425273796184898 2901 2865357 SGTC_75 0159-0059 199.013 µM -0.188669065797574 0.416970083751325 no 1969 0.425176099018299 3042 5377270 SGTC_1181 1222-0449 220 µM -0.189103144563121 0.41677915712989 no 1970 0.425005988474404 2916 658318 SGTC_419 nsc-638432 893 µM -0.189155439801721 0.416756156745318 no 1971 0.424985495505462 2822 368090 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.189343583003891 0.416673410345385 no 1972 0.424911769384212 2819 279621 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.189675987603413 0.416527226026741 no 1973 0.424781519162453 2899 6728940 SGTC_2880 9042983 58.44 µM -0.189751796885024 0.416493888368126 no 1974 0.424751815019782 2883 6464714 SGTC_794 k038-0031 316 µM -0.191196454963824 0.415858704989139 no 1975 0.424185840456755 2735 6624242 SGTC_608 k048-0125 159 µM -0.191365807976101 0.415784258670494 no 1976 0.424119503139298 2835 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1917 st066507 28.5 µM -0.193580485425003 0.414810982159617 no 1977 0.423252189759513 2753 3156428 SGTC_2470 5664817 21.68 µM -0.193841020718291 0.414696519876589 no 1978 0.423150183123407 2741 2859561 SGTC_2278 7948257 134.34 µM -0.193958231415974 0.414645027471689 no 1979 0.423104293634826 2896 1247028 SGTC_742 0kpi-0133 140 µM -0.195489076257228 0.413972639522932 no 1980 0.422505044297194 2918 2728852 SGTC_2022 5136654 200 µM -0.196716218506477 0.413433827809067 no 1981 0.422024808775933 2911 1713771 SGTC_2155 5570423 76 µM -0.196876662600194 0.413363392291321 no 1982 0.42196202839605 2769 797402 SGTC_906 1165-0455 526 µM -0.196976677857785 0.413319486654352 no 1983 0.421922894297997 2750 3252859 SGTC_361 000s-0510 1.45 µM -0.197423034347769 0.413123554111778 no 1984 0.421748252762452 2846 660 SGTC_851 0394-0702 453 µM -0.198844816547826 0.412499593375667 no 1985 0.421192068696251 2831 762646 SGTC_2958 9077254 16.72 µM -0.198865550436305 0.412490495770898 no 1986 0.421183959009348 2938 16457351 SGTC_1389 3405-0187 19 µM -0.199355358542115 0.412275591710302 no 1987 0.420992389126746 2807 799890 SGTC_3145 9085516 49.47 µM -0.199791527315515 0.412084244124927 no 1988 0.420821813979997 2837 25236195 SGTC_1345 1488-0192 31.4 µM -0.199802883476479 0.412079262447102 no 1989 0.420817373056196 2844 658348 SGTC_1071 trifluoperazine 6.31 µM -0.200020064547224 0.411983993002089 no 1990 0.420732444482041 2905 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1041 0206-0046 107 µM -0.200324708443633 0.411850365535867 no 1991 0.420613319821465 2856 50494 SGTC_2332 7982454 138.89 µM -0.201020427504975 0.411545237176643 no 1992 0.420341300625007 2812 2981748 SGTC_1246 0422-0085 105 µM -0.201573374829316 0.411302763764178 no 1993 0.420125130875586 2874 264295 SGTC_759 3486-0358 89.3 µM -0.201718057585595 0.411239324390844 no 1994 0.420068572436354 2871 875103 SGTC_2842 9000675 19.48 µM -0.202347035937445 0.410963561836584 no 1995 0.41982271552259 2826 2989072 SGTC_1972 st070201 17.4 µM -0.202634253957687 0.410837651657838 no 1996 0.419710457295933 2891 2829099 SGTC_913 3487-1245 167 µM -0.202838091803487 0.410748299119835 no 1997 0.419630791901676 2732 4016153 SGTC_2565 isoliquiritigenin 100 µM -0.202980325920032 0.410685953385626 no 1998 0.419575204877244 2906 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2439 5492030 7.2 µM -0.203081007446043 0.410641822836505 no 1999 0.419535858139502 2880 5722370 SGTC_1400 3771-8998 51.5 µM -0.204589940986049 0.409980565567276 no 2000 0.418946257549838 2781 670767 SGTC_1058 3448-5425 97.3 µM -0.205983735892784 0.409369992613339 no 2001 0.418401807881833 2715 7279705 SGTC_1219 1469-0211 33.1 µM -0.207066237899986 0.408895937775605 no 2002 0.41797906445078 2868 6822282 SGTC_2247 cerulenin 830 nM -0.207408300264143 0.408746167738621 no 2003 0.417845500433772 2999 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1307 1187-1599 12.2 µM -0.208712094694561 0.408175431216193 no 2004 0.417336498935136 2774 1538471 SGTC_3074 9116018 49.47 µM -0.209026279203016 0.408037925899289 no 2005 0.417213861942287 2738 17027303 SGTC_901 1112-0062 60.1 µM -0.209545370920557 0.40781076615405 no 2006 0.417011260286382 2781 1908457 SGTC_2375 9072683 200 µM -0.209622260647737 0.407777121070954 no 2007 0.416981252074923 2891 16798029 SGTC_2811 7967822 32.47 µM -0.210064842686848 0.407583471117606 no 2008 0.416808532357996 2921 2232244 SGTC_2833 9001315 45.46 µM -0.210975050788212 0.407185284321828 no 2009 0.41645336988116 2808 2989378 SGTC_36 0335-0881 14.2 µM -0.211531332896716 0.406941975964085 no 2010 0.416236342602464 2757 23828853 SGTC_1316 1272-0050 65.9 µM -0.212798727056678 0.406387773509649 no 2011 0.41574197833356 2770 7340392 SGTC_1861 st057647 17.4 µM -0.213280518417057 0.40617714629647 no 2012 0.415554084013923 2966 688668 SGTC_150 3970-0969 77.2 µM -0.213605001016814 0.406035305861569 no 2013 0.415427549580794 2893 6615640 SGTC_2038 4100038 30.985 µM -0.214625727235807 0.405589198334844 no 2014 0.415029566949988 2896 3596803 SGTC_3048 9093155 49.47 µM -0.215197381832398 0.405339410698832 no 2015 0.414806716053426 2828 25236002 SGTC_2629 bisabolol 100 µM -0.215911309757136 0.405027510092169 no 2016 0.41452844055624 2946 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.216331477548806 0.404843975502493 no 2017 0.414364687200584 2922 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_819 1013-0258 27.7 µM -0.217721487027331 0.404236951203314 no 2018 0.413823060517104 2808 5753198 SGTC_1885 st057546 99.9 µM -0.217776012234424 0.404213144453006 no 2019 0.4138018177319 2942 702008 SGTC_872 0588-0139 234 µM -0.218503782471583 0.403895420018581 no 2020 0.413518305766449 2787 2047100 SGTC_657 3534-0529 86.7 µM -0.218648149426481 0.40383240091234 no 2021 0.413462071173773 2964 1049549 SGTC_752 1896-0090 130 µM -0.219623493982504 0.403406708694253 no 2022 0.413082196278994 2785 772567 SGTC_1534 6-azauridine 81.6 µM -0.219776208946096 0.403340066112933 no 2023 0.413022724573929 2770 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_386 1509-0011 3.07 µM -0.222125698124697 0.402315138227838 no 2024 0.412108016656137 2784 3107280 SGTC_1075 aripiprazole 15.2 µM -0.223491714402373 0.401719543106551 no 2025 0.411576415506476 2790 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2795 7780010 54.55 µM -0.224807899596889 0.401145890618689 no 2026 0.411064360190841 2936 953673 SGTC_541 4513-1321 94 µM -0.22557988614336 0.400809523330688 no 2027 0.410764093087937 2821 747515 SGTC_2245 6637752 200 µM -0.225841362768786 0.400695610304029 no 2028 0.410662402605489 2966 681890 SGTC_1733 st037357 54.9 µM -0.226445444060585 0.40043247289654 no 2029 0.410427493228282 2760 1272339 YGL099W LSG1 SGTC_1708 st033234 31.827 µM -0.228145239283088 0.39969228605322 no 2030 0.40976666573203 2931 674664 SGTC_1169 aniline yellow 25.8 µM -0.229317197352175 0.39918215901191 no 2031 0.40931119401633 2861 6051 A DNA damaging agent. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.229954575075363 0.398904794997094 no 2032 0.409063533831891 2788 2333 A French combination drug. SGTC_3286 9117135 37.221 µM -0.230698349909939 0.39858119530125 no 2033 0.408774577766804 2844 3438150 SGTC_843 0310-0051 143 µM -0.230780574939399 0.398545425316644 no 2034 0.408742636434101 2846 2065037 SGTC_3314 9135860 59.4275 µM -0.231122289514607 0.39839677989691 no 2035 0.408609899664204 2916 25252478 SGTC_482 fipronil 114 µM -0.23167672996917 0.398155630352573 no 2036 0.408394553240745 2794 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3013 9080133 71.4286 µM -0.232739446038185 0.39769351909781 no 2037 0.407981868334292 3021 17050193 SGTC_2743 auranofin 4.32 µM -0.233943584297942 0.397170085307849 no 2038 0.407514388257524 2853 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2092 5303694 80.6725 µM -0.234010473014357 0.397141014486557 no 2039 0.407488424045451 2830 1963699 SGTC_2251 lansoprazole 556 µM -0.234357207010613 0.396990327947707 no 2040 0.407353838727631 2811 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_969 1313-0238 134 µM -0.234380233665505 0.39698032137713 no 2041 0.407344901284263 2828 5212874 SGTC_1557 sumaresinolic acid 42.3 µM -0.234745822003637 0.396821458694344 no 2042 0.407203010236234 2821 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1067 clotrimazole 1.36 µM -0.234791252783022 0.39680171840817 no 2043 0.407185378628788 2819 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1170 0310-0127 64.8 µM -0.234799964486702 0.39679793308568 no 2044 0.407181997653042 2896 774975 SGTC_1414 3917-0015 5.4 µM -0.235253866088482 0.396600721755084 no 2045 0.407005849913591 2862 6618702 SGTC_3087 9117406 49.47 µM -0.237284630517262 0.395718719035884 no 2046 0.406217992368824 2950 42546093 SGTC_741 4582-0002 126 µM -0.237857757949516 0.395469894392849 no 2047 0.40599570977788 2814 2912688 SGTC_728 3030-5151 22.5 µM -0.238301729825391 0.395277172222799 no 2048 0.405823539892573 2821 3125388 SGTC_2260 7964312 200 µM -0.240585802423187 0.394286093069573 no 2049 0.404938077523984 2999 231951 SGTC_3065 9113888 49.47 µM -0.24176003765669 0.393776847899898 no 2050 0.404483052882963 3031 16648368 SGTC_550 4123-0385 25.7 µM -0.242965128236532 0.393254410130131 no 2051 0.404016205868367 2841 5731123 SGTC_2764 methyldopa 94.69 µM -0.244015387053591 0.392799252590536 no 2052 0.403609451463285 3004 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_581 0958-0271 211 µM -0.24510117027162 0.392328853675976 no 2053 0.403189048406432 2834 4591145 SGTC_701 4424-0219 185 µM -0.246687802119172 0.391641752787756 no 2054 0.402574923687651 3007 2911779 SGTC_101 0490-5701 117.494 µM -0.246969999888392 0.391519580603229 no 2055 0.402465720817661 2804 4661669 SGTC_3030 9087619 49.47 µM -0.247468388920195 0.391303838643996 no 2056 0.402272876397155 2891 25236973 SGTC_3015 9080845 49.47 µM -0.247548042308392 0.391269361492038 no 2057 0.402242057874869 2965 5296973 SGTC_2084 5306078 60.6385 µM -0.248959736306868 0.390658466204454 no 2058 0.401695963356295 2906 679340 SGTC_1998 st075797 76.8 µM -0.250038049210237 0.390192019628407 no 2059 0.401278961970586 2903 24208315 SGTC_1622 st003707 19.4 µM -0.250853751151406 0.389839275817154 no 2060 0.4009635912346 2968 10140899 SGTC_1013 4112-3890 241 µM -0.251068326973248 0.38974649926882 no 2061 0.400880641575981 2832 705171 SGTC_2846 9008642 19.48 µM -0.251361783877267 0.389619626931054 no 2062 0.400767205694639 2991 2992898 SGTC_729 4092-0585 94.1 µM -0.252234127097973 0.389242550001486 no 2063 0.40043005052106 2824 2169061 SGTC_1681 tripelennamine 100 µM -0.253385158897969 0.388745167450998 no 2064 0.399985297511309 2827 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2222 6885208 172.143 µM -0.253929099496442 0.388510183845771 no 2065 0.399775166640157 2888 609514 SGTC_1758 st042942 75.2445 µM -0.254953596912983 0.388067709418282 no 2066 0.399379469677672 2849 669317 SGTC_2077 5212015 200 µM -0.256743610631068 0.387294961935785 no 2067 0.398688351626288 2799 780900 SGTC_1509 1326-1131 80 µM -0.257880048449611 0.386804594096275 no 2068 0.398249741617133 2939 768313 SGTC_592 k241-0073 46.5 µM -0.258098279686582 0.386710448945171 no 2069 0.398165529612727 2981 4230158 SGTC_2791 5663188 71.43 µM -0.258404910818882 0.386578179265378 no 2070 0.398047213493176 3026 54690634 SGTC_1795 st049545 62.3 µM -0.258813872592409 0.386401788322494 no 2071 0.397889426853291 2936 5291882 SGTC_137 0438-0332 85.389 µM -0.25902804720455 0.38630942117417 no 2072 0.397806800137812 2886 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1092 toremifene 6.32 µM -0.259486354615719 0.386111788450862 no 2073 0.397630004500705 2860 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2298 7976326 193.81 µM -0.261689705471064 0.385162066118559 no 2074 0.396780338939888 2864 2235818 SGTC_314 1671-0008 2.74 µM -0.26196293290351 0.385044343269283 no 2075 0.396675009865884 2856 3913060 SGTC_552 k242-0005 476 µM -0.262521782520854 0.384803590171728 no 2076 0.39645959703219 2991 4088318 SGTC_284 0988-0104 32.6 µM -0.262974997941119 0.384608377023207 no 2077 0.396284924905574 2957 4666532 SGTC_1100 amiodarone 5.07 µM -0.264339893966619 0.384020653254805 no 2078 0.395759011114984 2984 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3144 9087057 49.47 µM -0.26436496477665 0.384009860262036 no 2079 0.39574935274799 2929 17249618 SGTC_2658 polymyxin b sulfate 77.05 µM -0.265345242634547 0.383587920892254 no 2080 0.395371757300966 2898 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1777 st045864 34.765 µM -0.265894277720661 0.383351660892384 no 2081 0.395160316115857 2897 4691462 SGTC_147 4466-0538 29.23 µM -0.266936446326838 0.38290331574342 no 2082 0.394759047177564 3098 6742687 YHR072W ERG7 SGTC_578 3460-0051 92 µM -0.268053846171994 0.382422780053991 no 2083 0.394328935758035 2939 2876744 SGTC_2779 methotrexate 400 µM -0.268536562824122 0.382215244613158 no 2084 0.394143167468976 2967 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_68 0986-0284 82.829 µM -0.269916264129211 0.38162225331041 no 2085 0.393612337228943 3065 423278 YIL048W NEO1 SGTC_1764 st044502 93.5 µM -0.270986284505668 0.381162553032193 no 2086 0.393200790550977 3015 8407 SGTC_811 0416-0114 265 µM -0.271121082572962 0.381104653199605 no 2087 0.393148953545938 2965 6612453 SGTC_178 4092-0806 87.505 µM -0.271755858806914 0.380832033474143 no 2088 0.392904873902669 2963 2169044 SGTC_252 miconazole 1.30953 nM -0.273003401942755 0.380296418929637 no 2089 0.392425300252638 2989 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2757 clomiphene 4.22 µM -0.273474119268851 0.380094382838311 no 2090 0.392244392091576 3115 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_258 haloperidol 50.781 µM -0.273855263497888 0.379930816288802 no 2091 0.392097926118332 2932 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.274244068580386 0.379763984242054 no 2092 0.391948531986154 2834 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1032 k061-1018 98.7 µM -0.275225359810433 0.379343022384364 no 2093 0.391571552363675 3084 4005393 SGTC_2607 solasodine 47.35 µM -0.276266065838619 0.37889672857531 no 2094 0.391171858780659 2903 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1098 clofazimine 15.1 µM -0.276851780965283 0.378645622889166 no 2095 0.390946959519459 3009 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_400 oxethazaine 37.5 µM -0.277849389897682 0.378218049544909 no 2096 0.390563987816778 2962 4621 A local anesthetic. SGTC_2168 5727979 200 µM -0.27828862049037 0.378029843366598 no 2097 0.390395405388832 2843 695210 SGTC_1450 4112-4260 37.6 µM -0.278742808005202 0.377835258725644 no 2098 0.390221103969007 3050 1633175 SGTC_529 4076-0302 30.3 µM -0.278837446754568 0.377794717154147 no 2099 0.390184787675271 2907 5816522 SGTC_1848 st056003 16.4 µM -0.279392960011137 0.377556772223619 no 2100 0.389971636580454 2930 146492 SGTC_2956 9076196 2.52 µM -0.280214322823704 0.377205040186551 no 2101 0.389656539327952 3025 16423868 SGTC_323 4013-0906 34.3 µM -0.281202370785176 0.376782063571541 no 2102 0.389277593188807 2986 2910086 SGTC_3340 9146634 11.102 µM -0.285126152352935 0.375103783415032 no 2103 0.387773747301608 2987 4907387 SGTC_152 4469-0003 551.229 µM -0.286040058035145 0.374713225557846 no 2104 0.387423720420869 2888 697280 SGTC_765 1319-0117 244 µM -0.287753360821034 0.373981391584043 no 2105 0.386767770311023 2898 3487746 YGL099W LSG1 SGTC_964 1287-0107 19.4 µM -0.287876773506609 0.373928693592063 no 2106 0.386720533351996 3077 51516812 YPR165W RHO1 SGTC_2783 7738165 71.43 µM -0.288784719480487 0.373541067453193 no 2107 0.386373063118507 2974 17201110 SGTC_900 1112-0045 141 µM -0.289144964123258 0.373387304912211 no 2108 0.38623522299533 2949 56211 YIL048W NEO1 SGTC_758 0868-0029 16 µM -0.289358357723013 0.37329623203002 no 2109 0.386153579140844 3027 762687 SGTC_3318 9139014 38.6185 µM -0.291015238680266 0.372589343645261 no 2110 0.385519832442215 2899 16643984 SGTC_2198 6589944 200 µM -0.291441665313515 0.372407483145739 no 2111 0.385356776265174 2947 5290268 SGTC_78 0336-0123 156.75 µM -0.291592795710436 0.372343036563982 no 2112 0.385298992183279 2843 6765896 SGTC_914 3820-6779 408 µM -0.291991960427916 0.372172837824394 no 2113 0.385146385452953 2876 2893481 SGTC_199 4063-0024 41.6 µM -0.292131745595492 0.372113241114794 no 2114 0.385092947665295 3028 306215 SGTC_1358 1509-0022 2.48 µM -0.292480116914903 0.371964728072036 no 2115 0.384959779996194 2982 3258434 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.292487774839362 0.371961463661068 no 2116 0.384956852846859 2919 165521 SGTC_1254 0550-0035 264 µM -0.293100242137205 0.371700411649624 no 2117 0.384722765847939 3058 15121435 SGTC_1829 berberine 14.4 µM -0.295870553605659 0.370520359861328 no 2118 0.383664469805744 3101 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_273 hydroxyurea 18.1 mM -0.296377325942165 0.370304624679021 no 2119 0.383470969590373 2913 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_809 3998-0021 90 µM -0.298413998271161 0.369438016429958 no 2120 0.382693603216396 3100 715485 SGTC_3329 9141233 27.5565 µM -0.298503807618645 0.36939981759808 no 2121 0.382659335226808 3087 4909101 YNL103W MET4 SGTC_2206 7254556 146.969 µM -0.300775845734413 0.368433875823299 no 2122 0.381792714163967 2974 4398905 SGTC_2556 citropten 84.59 µM -0.301089308356281 0.368300674379219 no 2123 0.381673196834229 2952 2775 A potential DNA crosslinker. SGTC_1167 k781-0610 148 µM -0.301290097933504 0.368215360044566 no 2124 0.381596645517196 2980 4525169 SGTC_2563 tomatine 8.54 µM -0.30153095172545 0.368113031228713 no 2125 0.381504825769654 3118 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_484 loperamide 105 µM -0.302703545598033 0.367614978372802 no 2126 0.381057897747321 2919 3955 An opioid-receptor agonist. SGTC_670 4204-0025 119 µM -0.302895875020407 0.367533308723311 no 2127 0.380984607519936 3048 719039 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.303151494563746 0.367424773196704 no 2128 0.380887206179983 2975 2374 Ca(2+)-ATPase inhibitor. SGTC_2322 7413319 38.22 µM -0.303209404178419 0.367400186365738 no 2129 0.380865141333139 3062 1840400 SGTC_1418 3966-3099 2.4 µM -0.303260968164877 0.367378294171636 no 2130 0.380845494637377 3033 740335 SGTC_2347 9049783 174.81 µM -0.304374369502752 0.366905689691874 no 2131 0.380421346103631 3110 6467988 YPL169C MEX67 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.304809466671337 0.366721059139457 no 2132 0.380255635531779 3013 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_489 paxilline 115 µM -0.30670401836158 0.365917478808546 no 2133 0.379534335450003 3017 105008 A toxic potassium channel blocker. SGTC_3052 9092717 49.47 µM -0.306903153051644 0.365833049257142 no 2134 0.379458544516443 3119 25237534 SGTC_1671 st016596 74.5 µM -0.307290041919538 0.365669033866949 no 2135 0.379311307331458 2988 2829167 SGTC_1824 st053723 68.6 µM -0.307796100233707 0.365454535550874 no 2136 0.379118744596814 3013 675225 SGTC_1943 st076331 65.2 µM -0.309496070810371 0.36473429294417 no 2137 0.378472100295723 3059 24208415 SGTC_3164 9100705 49.47 µM -0.309822492446949 0.364596049330699 no 2138 0.378347973084479 3090 17174235 SGTC_1697 st025554 27.742 µM -0.311070469575973 0.364067678008883 no 2139 0.377873525037497 2929 1269519 SGTC_1610 st001799 48.1 µM -0.311442569033884 0.363910187658746 no 2140 0.377732098228877 2898 621897 SGTC_2133 5320837 200 µM -0.313435111682629 0.363067239661806 no 2141 0.376975055938138 3109 2841355 SGTC_823 0417-1665 178 µM -0.313668125233603 0.362968706164975 no 2142 0.376886556096147 3039 3429856 SGTC_1277 0873-0036 22 µM -0.314314554636495 0.36269540068538 no 2143 0.376641072490971 3034 5965735 SGTC_140 0062-0056 502.533 µM -0.316326241733597 0.361845322584142 no 2144 0.375877447484861 2919 3758964 SGTC_2694 st077685 81.9 µM -0.319940761979402 0.360319649600783 no 2145 0.374506618507595 2925 2838096 SGTC_144 4161-2749 112.381 µM -0.320228413948207 0.360198328098544 no 2146 0.374397592582408 2987 797501 YMR168C CEP3 SGTC_1239 0337-0584 35.4 µM -0.32065304018599 0.360019261390435 no 2147 0.374236668989882 3140 914301 YML130C ERO1 SGTC_1976 st070609 63.5 µM -0.322319656523665 0.359316739292895 no 2148 0.373605271669722 2906 682556 SGTC_1709 st033179 39.1045 µM -0.322762023397394 0.359130349889639 no 2149 0.373437737935116 2973 573381 SGTC_3037 9091026 49.47 µM -0.323239294976927 0.358929291135147 no 2150 0.373257011871639 3070 25236398 YIL048W NEO1 SGTC_3266 9136860 49.47 µM -0.323398085144654 0.358862406741839 no 2151 0.37319688976475 3076 4871271 YPR165W RHO1 SGTC_679 0422-0091 41.4 µM -0.323546657797058 0.358799830011437 no 2152 0.373140639071874 2978 627384 YHR062C RPP1 SGTC_1343 1487-0095 224 µM -0.324409476303996 0.358436497839633 no 2153 0.372814023156701 3114 4560101 YGL055W OLE1 SGTC_1493 4348-0038 111 µM -0.324474231471146 0.358409234655796 no 2154 0.37278951407557 3032 800424 SGTC_171 k064-0041 9.68 µM -0.324701391976593 0.358313601375725 no 2155 0.372703540526397 2991 53325 SGTC_2109 5483026 200 µM -0.325702227331943 0.357892361290762 no 2156 0.372324829441049 3011 759335 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.326183987863218 0.357689655468003 no 2157 0.372142577654975 2954 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1304 1165-0502 251 µM -0.326312770379074 0.35763547566215 no 2158 0.372093863603405 2996 767425 SGTC_2710 st078562 53.7235 µM -0.326342659254444 0.357622901589973 no 2159 0.372082557949706 2934 17250908 SGTC_2776 terbinafine 19.92 µM -0.327755060613574 0.357028889140877 no 2160 0.371548434206742 3032 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_399 oxolinic acid 75 µM -0.328562362947209 0.356689518168974 no 2161 0.371243249982074 2987 4628 A DNA gyrase inhibitor. SGTC_1434 4073-0095 163 µM -0.329400085088286 0.356337479323821 no 2162 0.370926651741732 3026 24133745 SGTC_298 1391-0729 10 µM -0.330349338822459 0.35593871910134 no 2163 0.370568008225747 2977 3237558 SGTC_2448 5185112 27.17 µM -0.331028121954913 0.355653674096617 no 2164 0.370311621842679 3116 5718189 SGTC_1294 1000-1494 117 µM -0.331353493462246 0.355517067714997 no 2165 0.370188744650837 3018 712797 YDL207W GLE1 SGTC_3100 9120536 49.47 µM -0.332245062896307 0.355142839748457 no 2166 0.369852109611017 2990 16421196 SGTC_1982 st072467 71.9 µM -0.3324496569356 0.355056982996514 no 2167 0.369774873909807 2936 3163533 SGTC_2425 5628681 7.85 µM -0.332573212969873 0.355005136956764 no 2168 0.369728233174336 3065 5714958 SGTC_1945 st075991 56.6 µM -0.332858799943791 0.354885310482065 no 2169 0.369620435281297 3029 1084980 SGTC_1677 st019204 53.9 µM -0.333358894764812 0.354675515466063 no 2170 0.369431693767345 3083 3945625 SGTC_1102 cgs 12066b 26.1 µM -0.333376618184609 0.354668081114072 no 2171 0.369425005322726 3028 6438352 A 5-HT1B full agonist. SGTC_44 0929-0055 61.211 µM -0.333767089676512 0.354504306088804 no 2172 0.369277659651272 2975 1379590 SGTC_1797 st048695 56.8 µM -0.334150242132914 0.354343627022578 no 2173 0.369133094506539 3114 592262 YIL048W NEO1 SGTC_666 0272-0154 136 µM -0.335506653457492 0.353775009976076 no 2174 0.368621463275726 3038 6870312 SGTC_2477 5967686 25.23 µM -0.33654664086546 0.353339260782666 no 2175 0.368229343102423 2954 776118 SGTC_272 doxorubicin 8.13 µM -0.336641310443884 0.353299604267697 no 2176 0.368193655390658 2995 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3306 9127676 59.7925 µM -0.336830769707624 0.353220245709447 no 2177 0.368122238106188 3066 41905287 SGTC_1565 sinapyl alcohol 95.1 µM -0.33736530366561 0.352996380572834 no 2178 0.36792076837075 3094 5280507 A phenol propionate derived from cinnamic acid. SGTC_104 0074-0074 590.992 µM -0.337948019074508 0.352752394796453 no 2179 0.367701180085679 2912 3943124 SGTC_3023 9089636 49.47 µM -0.341336140208542 0.351334974349975 no 2180 0.366425271931906 3100 17249241 SGTC_1201 1889-3372 45.9 µM -0.341902426107473 0.351098269547595 no 2181 0.366212161890177 3015 5392199 SGTC_839 0122-0028 230 µM -0.342266158258953 0.350946261703377 no 2182 0.3660753005388 3021 759448 SGTC_2941 9056145 11.23 µM -0.345477028659114 0.3496054391151 no 2183 0.364867888443813 3042 2119517 SGTC_1804 st050076 49.1 µM -0.345696544366962 0.349513840130807 no 2184 0.364785390766149 3133 3895976 SGTC_1568 digitonin 820 nM -0.347088033365456 0.348933406960435 no 2185 0.364262591665432 3185 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2724 maprotiline 69.64 µM -0.348114476998007 0.348505471866613 no 2186 0.363877106221031 3149 4011 A tricyclic antidepressant. SGTC_785 1270-0111 65.3 µM -0.349043348799981 0.348118381585421 no 2187 0.363528383001775 2979 6741994 SGTC_2729 fluphenazine 10.66 µM -0.349308912349221 0.348007741909224 no 2188 0.363428704138821 3008 3372 An atypical antipsychotic. SGTC_3124 9127567 49.47 µM -0.349457454964389 0.347945861396423 no 2189 0.363372952932431 3205 17592030 SGTC_2857 9024691 58.44 µM -0.349701553361209 0.347844182645849 no 2190 0.363281343892189 3113 16478292 SGTC_296 1222-0039 74.9 µM -0.349861214121482 0.347777682160051 no 2191 0.363221428150284 3052 5984176 SGTC_1919 st067113 52.3 µM -0.351928545339189 0.346917039194266 no 2192 0.36244592543033 3156 1268243 SGTC_1104 tacrolimus 29.8 µM -0.353224371197773 0.346377980803434 no 2193 0.361960119207676 3064 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_853 0419-0306 21 µM -0.354187555138097 0.345977501555418 no 2194 0.361599164719103 3014 762713 SGTC_526 4469-0568 170 µM -0.354602686146024 0.345804948611694 no 2195 0.36144363176045 3016 2901964 SGTC_782 0083-0095 30.5 µM -0.354622257278979 0.345796814484122 no 2196 0.361436299805861 2983 3591729 An indicator and reagent. SGTC_2219 9098279 200 µM -0.35583108934299 0.345294539450468 no 2197 0.360983532484126 3121 902349 SGTC_2716 st080858 38.6235 µM -0.355839460868033 0.345291061993625 no 2198 0.360980397612682 3175 5296050 SGTC_2314 7727897 200 µM -0.356301609542304 0.345099109825798 no 2199 0.360807352039068 3016 900724 SGTC_595 3909-8003 73.7 µM -0.356683850725138 0.344940377119414 no 2200 0.360664248315607 3146 699517 SGTC_2287 7945887 168.79 µM -0.357168553099765 0.344739134750122 no 2201 0.360482813155833 3118 1245853 SGTC_2487 5918373 44.05 µM -0.360513274771764 0.343351648101204 no 2202 0.359231665639991 3175 2876279 SGTC_3098 9119039 49.47 µM -0.362723889964652 0.342435777426352 no 2203 0.358405575898209 3034 17161528 SGTC_1853 st056710 91.2 µM -0.36288416736936 0.342369409499665 no 2204 0.358345707177454 3186 269167 SGTC_937 3122-0005 46.7 µM -0.363286179763661 0.342202964977317 no 2205 0.358195558053633 3190 759535 SGTC_518 1021-0119 62.6 µM -0.363748286792466 0.342011677441024 no 2206 0.358022991048266 3083 1097762 SGTC_3154 9100113 49.47 µM -0.363820116579383 0.341981947399689 no 2207 0.357996169885174 3054 25237525 SGTC_940 3232-1287 54.8 µM -0.3640017857201 0.341906759692797 no 2208 0.357928337957079 3125 1585493 YIL048W NEO1 SGTC_1376 2910-0861 41.3 µM -0.365187254850183 0.341416281687678 no 2209 0.357485815727509 3042 1112859 SGTC_755 1995-0008 37.3 µM -0.366489342710993 0.340877862173821 no 2210 0.356999981788081 3172 689533 SGTC_70 0141-0289 43.283 µM -0.366635292079348 0.340817531588026 no 2211 0.356945539714343 3095 352408 SGTC_2079 5212404 121 µM -0.366809389205856 0.340745570985395 no 2212 0.356880601766203 3190 758462 SGTC_3316 9136639 10.545 µM -0.36701045398544 0.340662470893313 no 2213 0.356805610087055 3149 4903665 SGTC_1802 st050112 57.9 µM -0.367082683169239 0.340632620452703 no 2214 0.356778671922258 3066 4662563 SGTC_1808 st050063 61.5 µM -0.367700837222827 0.340377194320929 no 2215 0.356548158105236 3197 4011993 SGTC_222 nsc-310342 10.666 µM -0.368001005989718 0.340253188617292 no 2216 0.356436242038515 3150 432556 SGTC_523 1934-0222 13.7 µM -0.368022117499443 0.340244467681653 no 2217 0.356428371207982 3053 1361595 SGTC_996 3970-0799 1.8 µM -0.368112550264886 0.340207111854346 no 2218 0.356394656595888 3111 6615648 YGL040C HEM2 SGTC_3035 9091303 49.47 µM -0.368437491767296 0.340072898463306 no 2219 0.356273523077985 3084 25237002 SGTC_1575 cyproterone acetate 48 µM -0.369826890698736 0.339499251774818 no 2220 0.355755738843782 3091 9880 An androgen receptor antagonist and liver toxin. SGTC_3036 9090181 49.47 µM -0.371311016902751 0.338886905184332 no 2221 0.355202946636186 3030 25236586 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.371639577870129 0.338751399257933 no 2222 0.35508060873127 3300 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_232 clozapine 119 µM -0.371785003960242 0.338691428931408 no 2223 0.355026464878852 3081 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1206 3978-0017 132 µM -0.371796189430881 0.338686816473637 no 2224 0.355022300517135 3311 3873677 SGTC_351 caspofungin 25 nM -0.37199931385301 0.338603059985757 no 2225 0.354946680108318 3081 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2917 7979103 53.79 µM -0.373080125045861 0.338157531741766 no 2226 0.354544405224205 3207 2980565 SGTC_3268 9137683 49.47 µM -0.374115096228892 0.337731111820997 no 2227 0.35415934386202 3035 1953228 SGTC_1574 spiramycin 23.7 µM -0.376771065548526 0.336637776030911 no 2228 0.353171872574923 3016 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3341 9147222 25.867 µM -0.378767946773872 0.335816663172382 no 2229 0.352430095856309 3198 1939759 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.380732627414145 0.335009555283568 no 2230 0.351700827940462 3209 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_730 1436-0052 41.2 µM -0.381756314921894 0.334589316994042 no 2231 0.351321062292383 3097 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_691 1548-0686 185 µM -0.381954929637839 0.334507806803278 no 2232 0.351247397758947 3108 46495133 SGTC_3152 9099253 49.47 µM -0.382588100172872 0.334248009808203 no 2233 0.351012597429636 3128 25236131 SGTC_2401 5128683 200 µM -0.383197575459617 0.333998010217044 no 2234 0.350786637791208 3072 708373 SGTC_2144 5628481 200 µM -0.383591999306535 0.333836261441248 no 2235 0.350640435420243 3096 2818399 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.384672174259874 0.333393451968411 no 2236 0.350240156743601 3311 6710655 SGTC_2780 5215298 71.43 µM -0.384916119153913 0.333293480723948 no 2237 0.350149781484023 3230 2834131 SGTC_1874 staurosporine 7.6 µM -0.384919542353853 0.333292077943986 no 2238 0.350148513337547 3188 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2998 9066762 71.4286 µM -0.385565555707463 0.333027392373195 no 2239 0.34990922345468 3268 4945196 SGTC_2805 7950783 58.44 µM -0.385649964885583 0.332992814256999 no 2240 0.3498779618413 3189 1178958 YDL195W SEC31 SGTC_2735 sertaconazole 140 nM -0.386349860497582 0.332706157603063 no 2241 0.349618789129254 3137 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1738 st035555 74 µM -0.387471025388119 0.33224716526233 no 2242 0.349203765655685 3186 5331140 SGTC_2766 oltipraz 83.91 µM -0.387754023587459 0.332131348698843 no 2243 0.349099036215521 3217 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1149 3909-7961 23.3 µM -0.388131464381495 0.331976906606186 no 2244 0.348959374190795 3111 735261 SGTC_2131 toluylene red 5.2905 µM -0.388374908006892 0.331877308923147 no 2245 0.348869305141169 3070 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1223 0764-0573 147 µM -0.388548307208197 0.331806375066565 no 2246 0.348805156255917 3086 1609797 SGTC_1444 4112-3581 28 µM -0.388588859719144 0.331789786782714 no 2247 0.348790154512898 3108 2877249 SGTC_2624 nerol 100 µM -0.388651207986256 0.331764283438026 no 2248 0.348767090244898 3062 637566 A natural product oil. SGTC_448 monastrol 171 µM -0.389932246649883 0.331240451696002 no 2249 0.348293324084193 3133 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2610 ononetin 44.17 µM -0.390415089465939 0.331043097193064 no 2250 0.348114815823056 3147 259632 SGTC_547 1120-0019 610 nM -0.391877321554838 0.330445719003303 no 2251 0.347574430152406 3082 3676939 SGTC_276 colchicine 750 µM -0.391878588314623 0.330445201670068 no 2252 0.34757396213997 3230 2833 A microtubule depolymerizer. SGTC_2036 5160441 105 µM -0.392491204207983 0.330195052866742 no 2253 0.347347654549137 3131 134534 YIL048W NEO1 SGTC_3317 9138495 8.753 µM -0.393753736221553 0.329679763926471 no 2254 0.346881431908116 3110 17020139 SGTC_35 0133-0054 64.071 µM -0.395605442979504 0.328924594318056 no 2255 0.34619806055434 3126 99677 SGTC_2279 7948423 32.93 µM -0.396490558607556 0.328563869617832 no 2256 0.345871585768723 3276 1247112 SGTC_3051 9093778 49.47 µM -0.396568364963878 0.328532167636254 no 2257 0.345842892378564 3165 17217378 SGTC_854 0422-0053 192 µM -0.397177676829082 0.328283947920555 no 2258 0.345618221271378 3145 3596728 SGTC_3070 9117005 49.47 µM -0.39735394379006 0.328212154921857 no 2259 0.345553236622348 3191 8779016 SGTC_1548 st061468 90.8 µM -0.398135817027639 0.327893776843804 no 2260 0.345265036941107 3200 390799 SGTC_195 4234-0266 16.654 µM -0.3997339380276 0.327243412590851 no 2261 0.344676246282503 3130 2303354 SGTC_89 0302-0250 142.109 µM -0.400762243579737 0.326825214891388 no 2262 0.344297589656564 3165 4203518 YLR208W SEC13 SGTC_2908 7930301 100 µM -0.402805577180743 0.325994864965749 no 2263 0.343545628975434 3106 2223178 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.402850575626566 0.325976588625041 no 2264 0.343529076193356 3142 688788 SGTC_1695 st026914 34.495 µM -0.403502563307537 0.325711827545371 no 2265 0.343289274705676 3099 3289191 SGTC_1937 st074714 47.2 µM -0.403695558869174 0.325633472191154 no 2266 0.34321830290984 3080 17250970 SGTC_613 3914-0030 117 µM -0.40397113842717 0.325521601449617 no 2267 0.343116971428019 3030 1145395 SGTC_2904 7225135 42.03 µM -0.404886230685615 0.325150235120414 no 2268 0.342780570042667 3225 4446116 SGTC_1857 st056007 79.3 µM -0.408023002578746 0.323878577401669 no 2269 0.341628393662366 3212 619834 SGTC_321 4534-3890 65.3 µM -0.408768160694274 0.323576789052137 no 2270 0.341354903841416 3216 699746 SGTC_2680 butyl paraben 22.24 µM -0.409357711973347 0.323338103506598 no 2271 0.341138584247549 3198 7184 An antifungal and steroid mimetic. SGTC_2528 xanthyletin 44.79 µM -0.409442108081117 0.323303940870582 no 2272 0.341107621691425 3091 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2621 lithochol-11-enic acid 100 µM -0.410928531238253 0.322702497190081 no 2273 0.340562470408619 3249 6708711 SGTC_2128 5255449 168.493 µM -0.41124216862852 0.322575650892009 no 2274 0.34044748521241 3117 736008 SGTC_125 0133-0007 11.75 µM -0.412493404705854 0.322069811408259 no 2275 0.339988906899587 3273 26541 SGTC_2794 7785382 27.27 µM -0.413492768277064 0.321666033458192 no 2276 0.339622809859496 3252 2205081 SGTC_1184 1269-1718 139 µM -0.415403869527683 0.320894468106182 no 2277 0.338923137223965 3266 5403821 SGTC_253 dyclonine 31.25 µM -0.415854379457453 0.320712697016963 no 2278 0.338758281977664 3190 3180 An oral anasthetic. SGTC_271 rotenone 740 µM -0.41598086555929 0.320661670314737 no 2279 0.338712002428207 3259 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_902 1120-0002 2.07 µM -0.41754092768656 0.320032592907106 no 2280 0.338141397266326 3133 3280475 SGTC_1946 st076057 65.1 µM -0.418948931350299 0.319465275194173 no 2281 0.337626727673774 3160 953009 SGTC_3072 9116419 49.47 µM -0.420700664461892 0.318760050411861 no 2282 0.336986837948447 3172 17170162 SGTC_112 phenothiazine 287.218 µM -0.42127884766393 0.318527425265364 no 2283 0.336775737085021 3285 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1474 0330-0125 5.35 µM -0.424331678378636 0.317300342537478 no 2284 0.335661969747977 3241 X1474 SGTC_1728 st035614 33.7865 µM -0.424696615932947 0.317153790138395 no 2285 0.335528925523669 3189 15945546 SGTC_1209 2323-2347 50.3 µM -0.424774542425613 0.317122499965781 no 2286 0.335500518759519 3248 5412760 SGTC_633 0437-0093 97.7 µM -0.424832833900087 0.317099094784504 no 2287 0.335479270218669 3169 2831118 SGTC_2119 5528445 120.635 µM -0.425939602433863 0.316654844219402 no 2288 0.335075928344514 3294 791935 SGTC_1686 st019653 115.5 µM -0.427458398880664 0.316045638315963 no 2289 0.33452273981849 3272 97252 SGTC_1737 st035557 69.7 µM -0.427779919856525 0.315916736692687 no 2290 0.334405678817392 3180 5716916 SGTC_3138 9097216 49.47 µM -0.429337679143137 0.315292529391757 no 2291 0.333838749987769 3231 25237486 SGTC_1351 1496-0003 46.5 µM -0.429711803696912 0.31514269292369 no 2292 0.33370264800422 3291 3891978 SGTC_1716 st033144 30.6155 µM -0.432163172638895 0.314161675678458 no 2293 0.332811411701601 3323 674617 SGTC_2778 tioconazole 65.09 nM -0.432184323711779 0.314153216894202 no 2294 0.332803725974204 3206 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3088 9117578 49.47 µM -0.432340522484494 0.314090752555175 no 2295 0.332746969743357 3272 678341 SGTC_1320 1313-0481 95.3 µM -0.432680914329701 0.313954647325728 no 2296 0.33262329857909 3327 6813365 YLR208W SEC13 SGTC_360 0957-0399 1.01 µM -0.432718569224467 0.313939592620054 no 2297 0.332609618921439 3289 6752301 YPR165W RHO1 SGTC_1609 st001574 46.4 µM -0.434139336068603 0.313371785992277 no 2298 0.332093631129636 3157 3960012 SGTC_2576 guaiol 23.12 µM -0.434575247072649 0.3131976635904 no 2299 0.331935382652892 3212 227829 SGTC_2301 7769476 200 µM -0.435222499988773 0.312939198577966 no 2300 0.331700466169403 3211 977820 SGTC_1466 k213-0079 57.5 µM -0.436796701360326 0.312310962620943 no 2301 0.33112939573532 3185 3657981 SGTC_1160 4092-0570 10.5 µM -0.437055845485469 0.312207594998501 no 2302 0.33103542404642 3174 4994975 SGTC_1788 fluconazole 20 µM -0.437816184936433 0.31190439549966 no 2303 0.330759768713052 3259 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3180 9109287 49.47 µM -0.438763312866057 0.311526888844326 no 2304 0.330416522964734 3263 18891271 SGTC_711 k292-0785 179 µM -0.438922988715698 0.311463264673669 no 2305 0.330358669367665 3167 4146315 SGTC_390 dec-rvkr-cmk 16.7 µM -0.439594338002912 0.311195821580047 no 2306 0.330115471127533 3234 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1082 camptothecin 424.86 nM -0.440472238800554 0.310846245631123 no 2307 0.329797557290302 2970 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1873 rapamycin 2 nM -0.440686149256253 0.310761093343385 no 2308 0.329720112604628 3187 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1950 st077106 7.18 µM -0.44145272204342 0.310456023563223 no 2309 0.329442640618341 3230 13831864 SGTC_1044 1222-0021 1.78 µM -0.441525246181751 0.310427168179415 no 2310 0.329416394328123 3230 4306703 SGTC_510 ag-490 170 µM -0.442666940470643 0.309973072884667 no 2311 0.329003329065392 3301 5328779 SGTC_1850 st056238 17 µM -0.445231956402887 0.308953925753513 no 2312 0.328076067527622 3248 5393177 SGTC_1605 st000082 49.1 µM -0.446291523263216 0.308533360720592 no 2313 0.327693339301003 3284 1114022 SGTC_393 acivicin 6.25 µM -0.446383559390361 0.308496841432746 no 2314 0.327660103286823 3129 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.447067967572098 0.308225332525899 no 2315 0.327412993184957 3209 6312947 SGTC_1481 3346-2004 36 µM -0.447226166384331 0.308162589009949 no 2316 0.327355885210565 3281 2770522 SGTC_2265 7929201 200 µM -0.448487829122685 0.307662399413183 no 2317 0.326900583985887 3110 1265108 SGTC_1362 1611-0397 101 µM -0.449231312832508 0.307367810544815 no 2318 0.326632400647063 3205 27816 SGTC_2071 5230951 39.92 µM -0.451378523457906 0.306517724115718 no 2319 0.32585837969022 3312 1799272 SGTC_483 fpl-64176 144 µM -0.451962336857281 0.306286770469562 no 2320 0.325648057671878 3281 3423 SGTC_396 dithiazanine 1.25 µM -0.452175357432385 0.306202519756625 no 2321 0.325571329641083 3193 10578 An antihelmenthic. SGTC_702 1488-0190 94 µM -0.453461850768034 0.305693923102464 no 2322 0.325108103889645 3292 949357 SGTC_2867 9039098 71.43 µM -0.453983622200294 0.305487754981382 no 2323 0.324920307391525 3169 6463460 SGTC_1522 st012842 45.6 µM -0.455176545689843 0.305016625550674 no 2324 0.324491116331727 3139 3491067 YOR116C RPO31 SGTC_966 1300-0360 30.2 µM -0.455387394267645 0.304933387248477 no 2325 0.324415281260683 3190 70588 SGTC_999 SEC7.066 22.7 µM -0.456040007205487 0.304675814239068 no 2326 0.32418060471299 3186 740511 YDR170C SEC7 SGTC_1296 1068-0102 11.9 µM -0.457161591595185 0.304233373946375 no 2327 0.32377745141623 3264 767053 SGTC_411 enrofloxacin 100 µM -0.457745437121744 0.304003173089055 no 2328 0.323567670016436 3375 71188 A bacterial gyrase inhibitor. SGTC_1278 0874-0585 172 µM -0.458638419199857 0.303651234983455 no 2329 0.323246921290804 3256 766306 SGTC_1614 st002383 48.6 µM -0.458990788289994 0.303512410913696 no 2330 0.323120390558701 3293 1947235 SGTC_2083 5306046 65.942 µM -0.459435238947505 0.303337349588223 no 2331 0.322960823828415 3240 539837 SGTC_148 3253-0744 288.01 µM -0.459481233408241 0.30331923575305 no 2332 0.322944312751204 3302 6893655 SGTC_625 k213-0058 121 µM -0.460310425819911 0.302992760809015 no 2333 0.322646709393266 3280 3655420 SGTC_3243 9134147 49.47 µM -0.461162876006671 0.302657292691457 no 2334 0.322340877039688 3310 24282180 SGTC_1638 st008370 60.6 µM -0.462458399713164 0.302147779002288 no 2335 0.321876314039998 3283 24207134 SGTC_1882 5615643 20 µM -0.462529868368212 0.302119682460771 no 2336 0.321850694124011 3274 2253075 SGTC_1163 k060-0048 49.9 µM -0.462979466720354 0.301942958331633 no 2337 0.321689542585963 3234 6809982 SGTC_1803 st050068 52.4 µM -0.463026019112356 0.301924662584132 no 2338 0.321672858520754 3346 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_254 nsc-64875 3.808 µM -0.46368477960887 0.301665813817421 no 2339 0.321436801739823 3350 56993 SGTC_2945 9067681 61.76 µM -0.464070212485713 0.301514410796392 no 2340 0.32129872116996 3324 16456930 SGTC_1583 clindamycin 39.6 µM -0.464326978724865 0.301413568674915 no 2341 0.321206748874789 3204 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1252 0493-0875 34.8 µM -0.464589811198844 0.301310359832768 no 2342 0.321112615042979 3184 3960963 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.465036879404851 0.301134842019081 no 2343 0.320952523322113 3313 17037758 SGTC_1571 st070080 73.4 µM -0.467172968293727 0.300296855766261 no 2344 0.320188065975093 3382 4315245 SGTC_2350 9023895 38.85 µM -0.468576348443649 0.29974688500864 no 2345 0.319686243183203 3345 2997209 SGTC_2289 7946404 165.07 µM -0.469323235291009 0.299454373574793 no 2346 0.319419304710485 3205 1246120 YPR165W RHO1 SGTC_3168 9103419 49.47 µM -0.470458259164858 0.299010099760936 no 2347 0.319013824637007 3277 16649256 SGTC_2292 7671323 168.05 µM -0.470735745467015 0.298901530944844 no 2348 0.318914727330108 3365 937504 SGTC_160 3453-0671 289.699 µM -0.471768520880213 0.298497606458435 no 2349 0.3185460111535 3227 5322268 SGTC_2972 9093619 59.92 µM -0.471902470941649 0.298445236006499 no 2350 0.318498202141693 3175 25236256 SGTC_1889 st059080 5.18 µM -0.472165533255784 0.29834239871076 no 2351 0.318404319608402 3376 176925 Isolated from Daphnopsis sellowiana. SGTC_3056 9094900 49.47 µM -0.473390560422518 0.297863719149023 no 2352 0.317967281595606 3238 25236784 SGTC_182 3448-4371 550.524 µM -0.47376572610563 0.297717193179551 no 2353 0.317833488963008 3356 3491403 SGTC_3226 9131256 49.47 µM -0.473893950834014 0.297667120840531 no 2354 0.317787766554213 3269 17178073 SGTC_2177 5811945 192 µM -0.475323384043419 0.297109181083596 no 2355 0.317278247120395 3355 5343475 SGTC_2505 galangin 7.89 µM -0.481948943273151 0.29452934458647 no 2356 0.314921108231136 3172 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1437 4092-1038 11.6 µM -0.482329434432244 0.294381504680951 no 2357 0.314785970389657 3252 3977136 SGTC_136 0097-0015 404.482 µM -0.482452121329621 0.294333841971909 no 2358 0.314742401358859 3347 4861337 SGTC_611 3453-1652 23.7 µM -0.483971495769095 0.293743874815324 no 2359 0.31420304929183 3372 1560575 SGTC_1886 st057356 49.9 µM -0.483990865740163 0.293736357065101 no 2360 0.314196175839113 3234 24207747 SGTC_2270 7924575 90.91 µM -0.484306113504061 0.29361401762228 no 2361 0.314084318929098 3358 1262135 SGTC_481 bay k-8644 50 µM -0.484631132140423 0.293487911061692 no 2362 0.313969012975285 3271 2303 A calcium channel antagonist. SGTC_2973 9094665 17.96 µM -0.485956481708829 0.292973938066163 no 2363 0.313499010528715 3405 25237061 YIL048W NEO1 SGTC_328 k915-0120 63.5 µM -0.486176961365831 0.292888476185078 no 2364 0.313420852212204 3332 6624543 SGTC_2726 cimetidine 79.27 µM -0.486786185606172 0.292652390090444 no 2365 0.313204930541778 3288 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1661 st013063 9.66 µM -0.487346779747737 0.29243522722162 no 2366 0.313006300945332 3279 721395 SGTC_1828 st055811 49 µM -0.488286075480651 0.292071531005332 no 2367 0.312673611526226 3343 5877589 SGTC_834 0312-0008 75.7 µM -0.488911207325938 0.291829596100029 no 2368 0.312452280437788 3324 6385573 YIL048W NEO1 SGTC_3169 9102970 49.47 µM -0.490428019600424 0.291242956629405 no 2369 0.31191552667204 3360 17027839 SGTC_641 4092-0595 30 µM -0.491246071455918 0.290926797108153 no 2370 0.311626208602193 3349 786260 SGTC_574 1315-0397 40 µM -0.492176753189706 0.290567303709278 no 2371 0.311297198404073 3297 6794277 SGTC_493 zm226600 134 µM -0.492239052104488 0.290543247001024 no 2372 0.311275180164896 3416 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1949 st076024 69.1 µM -0.492704760880143 0.290363443221331 no 2373 0.311110606601453 3203 2921930 SGTC_1700 st030840 7.9285 µM -0.492834866847448 0.290313220402124 no 2374 0.311064636111261 3339 5499307 SGTC_50 0929-0078 56.389 µM -0.493583189831509 0.290024435732019 no 2375 0.310800287545279 3225 1377751 SGTC_3115 9123671 49.47 µM -0.495299493585922 0.289362607569818 no 2376 0.310194364172017 3402 3286988 SGTC_3273 9137859 49.47 µM -0.496084961696193 0.289059958130333 no 2377 0.309917234392659 3366 2377234 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.496163229064214 0.289029809017617 no 2378 0.309889625921052 3275 6708784 An antioxidant flavonoid SGTC_1994 st072947 40.9 µM -0.496872102019481 0.288756813813685 no 2379 0.309639622931305 3368 5286565 YDL195W SEC31 SGTC_2725 haloperidol 53.21 µM -0.497315458034907 0.288586133999334 no 2380 0.309483306330741 3271 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1507 4075-3230 155 µM -0.497355368735565 0.288570771814572 no 2381 0.30946923647406 3327 659771 SGTC_146 3448-8650 53.125 µM -0.497382311166812 0.288560401515232 no 2382 0.309459738523936 3274 2891488 YIL048W NEO1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.497415828747099 0.288547500647673 no 2383 0.309447922830085 3285 5106787 A p450 inhibitor. SGTC_3027 9089541 49.47 µM -0.498556322334076 0.288108688369277 no 2384 0.309045990886775 3361 9943819 SGTC_2730 imipramine 71.33 µM -0.498577986734976 0.288100355899544 no 2385 0.30903835814391 3385 3696 A tricyclic antidepressant. SGTC_2261 9010538 184.68 µM -0.498609554062837 0.288088214811739 no 2386 0.30902723657631 3341 6457250 SGTC_1967 st070177 51.4 µM -0.499396309697584 0.287785699307555 no 2387 0.308750109216733 3415 5729214 SGTC_1192 1488-0095 21.4 µM -0.500803639329625 0.287244941432382 no 2388 0.308254662049765 3356 915875 SGTC_3193 9111931 49.47 µM -0.500841619733591 0.287230354359029 no 2389 0.308241295969754 3268 17087244 SGTC_2082 5219693 150 µM -0.500945144957861 0.287190595371124 no 2390 0.308204864619598 3311 2834649 SGTC_1016 4226-1401 38 µM -0.50310840480732 0.286360389375065 no 2391 0.307444028921317 3364 2901613 SGTC_2642 cholecalciferol 100 µM -0.503403379833076 0.286247273525531 no 2392 0.307340347917771 3361 9821465 A vitamin D precursor, similar to steriods. SGTC_110 0850-0284 111.64 µM -0.503920446283916 0.286049042150712 no 2393 0.307158640973137 3251 3906265 SGTC_1143 3454-2408 5.08 µM -0.504523167011252 0.285818055267866 no 2394 0.306946893247844 3355 X1143 SGTC_2560 caryophyllene 100 µM -0.504833516648521 0.285699151380524 no 2395 0.306837886381576 3293 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1379 2144-0755 36.5 µM -0.505834731024952 0.285315717812859 no 2396 0.306486337394972 3446 5392327 SGTC_2192 5915882 198.485 µM -0.506750292956853 0.284965301150849 no 2397 0.306165018716988 3326 2876149 SGTC_13 0199-0087 65 µM -0.506762694284959 0.284960556150423 no 2398 0.306160667463476 3380 4589825 SGTC_1086 cerivastatin 2.18 µM -0.507582471645356 0.284646976260613 no 2399 0.305873092886947 3356 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2342 7990637 118.86 µM -0.509787306557093 0.283804404817437 no 2400 0.305100239723686 3390 2033102 YER133W GLC7 SGTC_2619 obliquin 87.91 µM -0.509806073106774 0.283797238361334 no 2401 0.305093665272223 3342 6708593 A bioactive alkalod. YER133W GLC7 SGTC_375 3970-0961 9.27 µM -0.510694110592766 0.283458219088735 no 2402 0.304782632644045 3310 2898222 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.511025558563295 0.283331734500011 no 2403 0.304666580057138 3364 97141 SGTC_4 0960-0234 25.671 µM -0.511763342885738 0.283050284213181 no 2404 0.304408324185549 3371 6821112 SGTC_2871 9038510 12.99 µM -0.513144652057786 0.282523702878531 no 2405 0.30392506947666 3444 4945164 SGTC_1087 pterostilbene 9.05 µM -0.516786135754605 0.281137762034182 no 2406 0.302652729648227 3410 5281727 Similar to reservatol, lowers cholesterol. SGTC_2434 5670830 169.91 µM -0.518198991121728 0.280600917945604 no 2407 0.302159719307953 3376 1549830 SGTC_2959 9079155 11 µM -0.519421355166791 0.280136855604893 no 2408 0.301733471268954 3426 16189457 SGTC_275 trichlorophene 5.69 µM -0.520168543519971 0.279853373806573 no 2409 0.301473053966281 3397 62616 SGTC_1326 1431-2094 10.8 µM -0.520205474608198 0.279839365833372 no 2410 0.30146018501027 3271 616278 SGTC_2479 5617353 43.85 µM -0.522383285553612 0.279013923397528 no 2411 0.300701745607037 3445 2731746 SGTC_1642 st009582 77.7 µM -0.522692924616995 0.278896659009243 no 2412 0.300593981382371 3438 6739311 SGTC_1014 4130-3005 69.3 µM -0.523610694179106 0.278549228530821 no 2413 0.300274670918359 3297 743608 SGTC_1119 parthenolide 318.541 nM -0.524754196482235 0.278116639941254 no 2414 0.299877038169852 3479 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2005 4024620 188 µM -0.524828731296477 0.278088454691964 no 2415 0.299851128279885 3396 236743 SGTC_2719 novobiocin 32.65 µM -0.526216479519933 0.277563934029086 no 2416 0.299368902641605 3432 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1215 3852-0577 11.2 µM -0.526311353862958 0.277528092482433 no 2417 0.29933594780875 3453 2884876 SGTC_865 0488-0499 301 µM -0.526899245627764 0.277306049687353 no 2418 0.299131778878011 3455 9634651 SGTC_1197 1601-0112 267 µM -0.527305437029552 0.277152684674031 no 2419 0.298990749601423 3312 7350313 SGTC_2865 9030313 51.95 µM -0.530638754555656 0.275895699508754 no 2420 0.297834567301791 3269 42562754 SGTC_3172 9105863 49.47 µM -0.530870032891687 0.275808589070705 no 2421 0.297754422641528 3371 2348785 SGTC_3134 9127454 49.47 µM -0.530893176015003 0.275799873011991 no 2422 0.297746403418682 3469 24262820 SGTC_1814 st052110 31.539 µM -0.531482409506336 0.275578004156857 no 2423 0.297542263885577 3428 674163 SGTC_1627 st003713 25.6 µM -0.531924835099447 0.275411471779637 no 2424 0.29738902785915 3386 16195070 YER133W GLC7 SGTC_2720 fluspirilene 36.88 µM -0.532240849791813 0.275292551754151 no 2425 0.297279596872076 3388 3396 An atypical antipsychotic. SGTC_1871 st057448 67.3 µM -0.532709916104383 0.275116083224896 no 2426 0.297117200417938 3524 691747 SGTC_5 0352-0601 109.883 µM -0.534064955124015 0.274606613968145 no 2427 0.296648297446321 3363 762456 SGTC_2442 5158906 48.48 µM -0.534255187755344 0.274535127336868 no 2428 0.296582495746352 3414 1893835 SGTC_1113 artemisinin 1.17947 µM -0.534728267998765 0.274357390541444 no 2429 0.296418885708479 3427 2240 An anti-malaria and mitochondrial poison. SGTC_245 methotrexate 289.6 µM -0.535114608123744 0.274212284257547 no 2430 0.296285304563041 3383 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2807 7945238 51.95 µM -0.535960919784169 0.273894548834514 no 2431 0.295992779958301 3402 17148797 SGTC_480 am 92016 50 µM -0.536419807378973 0.273722342285279 no 2432 0.295834222554614 3387 2129 K+ channel blocker. SGTC_2194 5927483 104.545 µM -0.537398379968592 0.273355292743642 no 2433 0.295496231063944 3388 760979 SGTC_3143 9086658 49.47 µM -0.538590423154397 0.272908502775957 no 2434 0.295084748555111 3401 25236626 SGTC_283 0987-0079 11.7 µM -0.54057478382712 0.272165548231131 no 2435 0.294400351171231 3441 411556 SGTC_2996 9066192 71.4286 µM -0.540581191506477 0.272163150793381 no 2436 0.294398142377912 3368 6472854 SGTC_2068 5226020 147 µM -0.542652563579093 0.271388696094865 no 2437 0.293684520368813 3384 1810509 SGTC_18 0111-0177 500 nM -0.543141645370702 0.271205996180595 no 2438 0.293516140497569 3462 721752 SGTC_2264 7948757 110.76 µM -0.543872668853098 0.270933031631401 no 2439 0.293264548927472 3306 2971411 SGTC_2618 avocadyne 43.43 µM -0.544073769613773 0.270857964552536 no 2440 0.293195354930263 3379 3015189 SGTC_2751 anetholtrithion 17.25 µM -0.544280695317185 0.270780733970921 no 2441 0.293124164611019 3425 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_985 1493-0307 8.71 µM -0.544444335521132 0.270719666558985 no 2442 0.293067871828434 3468 3278274 SGTC_636 0kpi-0074 126 µM -0.545453682526644 0.270343149535024 no 2443 0.292720763958055 3398 616434 SGTC_1519 esterone 74 µM -0.546046017379865 0.270122312633008 no 2444 0.292517152794787 3323 698 A steroid. SGTC_815 1582-0027 36.9 µM -0.546947970255755 0.269786215979746 no 2445 0.292207238981995 3438 3128206 SGTC_2044 5102272 200 µM -0.548076518037153 0.269365977908041 no 2446 0.291819681748636 3434 592666 SGTC_2250 alverine citrate 130 µM -0.549012285177965 0.269017774762493 no 2447 0.291498509485213 3394 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2431 5490079 200 µM -0.549155661567744 0.268964443732135 no 2448 0.291449314675219 3389 5722345 SGTC_1870 st057514 26.5 µM -0.549226987334188 0.268937915004794 no 2449 0.29142484306806 3349 5393161 SGTC_2943 9068529 45.32 µM -0.550376219331735 0.268510653714533 no 2450 0.291030678031179 3465 3270634 SGTC_3161 9100388 49.47 µM -0.550889032239574 0.268320110378679 no 2451 0.290854873213103 3438 25236368 SGTC_246 cycloheximide 667 µM -0.551497118463055 0.268094254987445 no 2452 0.290646470726901 3342 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1348 1493-0373 93.8 µM -0.551623353337139 0.268047380826597 no 2453 0.290603216438979 3388 3010129 SGTC_2243 6634756 200 µM -0.551779209942345 0.267989513069525 no 2454 0.290549816441373 3522 885676 SGTC_2557 derrustone 83.84 µM -0.552076441813245 0.267879171749103 no 2455 0.290447990810818 3460 629853 An antioxidant. SGTC_2056 5235370 200 µM -0.552863586708849 0.267587070711824 no 2456 0.290178411608502 3354 5511916 SGTC_2090 5301565 104.445 µM -0.553372790045927 0.267398196381124 no 2457 0.290004083533162 3404 2056344 SGTC_2372 9071633 200 µM -0.553576448366569 0.267322674016121 no 2458 0.289934373930517 3468 21321366 SGTC_2769 toremifene 3.73 µM -0.554980374397749 0.266802350818575 no 2459 0.289454042171349 3511 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2814 7977482 42.97 µM -0.555121026741936 0.266750250452584 no 2460 0.289405940735512 3479 6456762 SGTC_1762 st045503 25.4615 µM -0.555420932877121 0.26663917655659 no 2461 0.289303388931421 3426 4645554 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.559565415717532 0.265106615033904 no 2462 0.287887950020273 3345 688803 SGTC_1465 k213-0056 144 µM -0.56129144359627 0.264469680599394 no 2463 0.287299436798705 3357 24048857 YMR208W ERG12 SGTC_1924 st058459 75.1 µM -0.561966483285769 0.264220791174038 no 2464 0.287069427578513 3433 688683 SGTC_2405 ticlatone 3.52 µM -0.562942568583027 0.263861116277482 no 2465 0.28673699606313 3230 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1521 st012942 49.4 µM -0.56304530651377 0.263823273194079 no 2466 0.286702016577536 3476 24207259 SGTC_774 k060-0086 136 µM -0.563361166076696 0.263706944991816 no 2467 0.286594487616641 3508 5911235 SGTC_2399 5884133 200 µM -0.563405004021695 0.263690801943423 no 2468 0.286579565253302 3390 722445 SGTC_746 1095-0025 46.6 µM -0.563442215894081 0.263677099300281 no 2469 0.28656689868323 3494 6749286 SGTC_2383 9036125 200 µM -0.566060921959187 0.262713718094943 no 2470 0.285676183504739 3397 79580 SGTC_2775 cyproheptadine 69.59 µM -0.566073952438393 0.262708928890602 no 2471 0.285671754670213 3511 2913 A selective serotonin reuptake inhibitor. SGTC_2202 7226349 200 µM -0.566112023968724 0.262694936388783 no 2472 0.285658815002645 3385 844334 SGTC_2451 5856223 45.7 µM -0.566280684730855 0.262632952765067 no 2473 0.285601494310211 3403 2179896 SGTC_880 0833-0487 87.2 µM -0.568494818795476 0.261819942635897 no 2474 0.284849511426683 3450 76075 SGTC_1390 3413-2614 145 µM -0.568939471730455 0.261656825869566 no 2475 0.284698608626517 3451 3421432 SGTC_1862 st057513 3.81 µM -0.569173459365859 0.261571010643101 no 2476 0.284619215078274 3409 5393163 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.570469787009695 0.261095842901167 no 2477 0.284179554183998 3535 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2785 7756463 72.73 µM -0.572151984375627 0.26047989709675 no 2478 0.283609506794412 3390 2201551 SGTC_1484 3473-2379 286 µM -0.572255139736783 0.260442150558814 no 2479 0.283574568299731 3554 671917 SGTC_554 4483-2211 187 µM -0.572957790492311 0.260185112051678 no 2480 0.283336636911391 3441 747107 SGTC_19 0279-0214 38.434 µM -0.573024800503755 0.260160605775332 no 2481 0.283313951002295 3501 3566274 YBR002C RER2 SGTC_2681 menadione 3.18 µM -0.573349468441229 0.260041888094369 no 2482 0.283204048607984 3500 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3343 9148379 18.9835 µM -0.573510379084028 0.259983060059944 no 2483 0.283149586797849 3522 1955036 SGTC_527 4476-4215 268 µM -0.574887367679021 0.259479921514936 no 2484 0.282683736908238 3365 4418754 SGTC_1314 1222-0010 41.1 µM -0.574898096852165 0.259476003152448 no 2485 0.28268010856138 3441 3526027 SGTC_2531 methyl deoxycholate 70.07 µM -0.575166243970285 0.259378084041023 no 2486 0.282589434961462 3378 16667744 Haematoxylin. SGTC_3256 9138902 49.47 µM -0.575568147280873 0.259231357023576 no 2487 0.282453558065895 3455 17228773 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.576261790519014 0.258978222428458 no 2488 0.28221912263782 3389 279621 SGTC_3239 9133757 49.47 µM -0.576858120902291 0.258760702933162 no 2489 0.282017651604972 3465 17036923 SGTC_2058 5236698 133 µM -0.577382401827929 0.258569542581824 no 2490 0.281840579819249 3412 766665 SGTC_1415 3966-0071 78.1 µM -0.577694621249593 0.258455737651352 no 2491 0.281735155608512 3482 2893185 SGTC_2025 5147754 141 µM -0.578086586513182 0.258312901861402 no 2492 0.281602831284382 3461 315777 YLR208W SEC13 SGTC_3135 9127742 49.47 µM -0.580058166863594 0.257595060512068 no 2493 0.280937696529607 3435 3643468 SGTC_223 busulfan 5 mM -0.580179466288566 0.257550929924294 no 2494 0.280896799615066 3477 2478 A DNA alkylator. SGTC_2601 securinine 100 µM -0.581954257242703 0.25690568312381 no 2495 0.280298746271297 3406 442872 A GABA receptor antagonist. SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.582038683309009 0.256875009974334 no 2496 0.28027031249578 3403 23665772 A membrane-active detergent. SGTC_1482 3346-2049 8.48 µM -0.583827224457088 0.256225656520539 no 2497 0.279668279935972 3476 3826804 SGTC_2047 4141938 200 µM -0.584708432714886 0.255906037230919 no 2498 0.279371891468591 3435 3807862 SGTC_2802 7925815 54.55 µM -0.585287684717294 0.255696052595415 no 2499 0.27917714711067 3430 1262923 SGTC_2091 4-phenylthiadiazole 200 µM -0.585403012156222 0.255654255989186 no 2500 0.279138381937087 3433 270010 SGTC_3146 9095609 49.47 µM -0.586214877981188 0.255360123136018 no 2501 0.27886556241781 3450 17173999 SGTC_2949 9072542 2.23 µM -0.588079520282968 0.254685247520346 no 2502 0.278239459368205 3509 16457352 SGTC_984 1492-0255 2.91 µM -0.588223859283941 0.254633045445929 no 2503 0.278191022320595 3452 1585198 SGTC_216 k038-0035 28.382 µM -0.589278701361162 0.254251718298807 no 2504 0.277837165012877 3465 4444231 YPR107C YTH1 SGTC_430 0958-0115 16.4 µM -0.589532046864932 0.254160178093926 no 2505 0.277752210471832 3398 6833180 SGTC_2200 6600604 21.907 µM -0.589708894243203 0.254096288862255 no 2506 0.277692915624705 3458 2904777 SGTC_1015 4130-4525 82 µM -0.590336695203382 0.253869552755696 no 2507 0.277482471288771 3408 1363237 SGTC_884 0851-0618 334 µM -0.590364532439842 0.253859501540397 no 2508 0.277473141810361 3508 9642473 SGTC_3285 9112818 20.8695 µM -0.590915246601437 0.253660697647324 no 2509 0.277288604875835 3509 17017947 YPR165W RHO1 SGTC_463 ikarugamyin 104 µM -0.59500226739714 0.252187871137339 no 2510 0.275920977679734 3518 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1313 1220-0047 237 µM -0.596418681817849 0.251678496809163 no 2511 0.275447781608503 3504 3528706 SGTC_279 1273-0055 2.93 µM -0.596895012490666 0.251507319812335 no 2512 0.275288738694067 3514 2847562 SGTC_123 0083-0120 66.675 µM -0.598752947311746 0.250840229798315 no 2513 0.274668821781231 3450 16001701 SGTC_2191 5911152 200 µM -0.600562159119799 0.250191535013687 no 2514 0.274065824098908 3471 2875902 SGTC_517 1365-0151 113 µM -0.600726799997987 0.250132547052398 no 2515 0.274010982929596 3556 768657 SGTC_1012 4112-3522 18 µM -0.601060410785338 0.250013042735885 no 2516 0.273899875240006 3524 3112398 SGTC_2066 5222451 176 µM -0.601135032748824 0.249986316191964 no 2517 0.273875025752927 3515 2281147 SGTC_330 1488-0319 80.1 µM -0.603371437639427 0.249186031265129 no 2518 0.273130809429173 3479 6846614 SGTC_2942 9052777 62.25 µM -0.603872469069153 0.249006926987714 no 2519 0.272964216953953 3580 6469503 SGTC_2969 9091408 28.7 µM -0.604140561902794 0.248911119675942 no 2520 0.272875097037008 3397 4286311 SGTC_2234 tolnaftate 200 µM -0.604324508483625 0.248845394739948 no 2521 0.27281395752215 3476 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2911 7942208 15.64 µM -0.604998741734874 0.24860456719645 no 2522 0.272589916373238 3501 1243384 SGTC_1365 1672-3266 55.4 µM -0.605303917484429 0.248495603128824 no 2523 0.272488539475 3534 6415873 SGTC_2690 usnic acid 100 µM -0.605375282131942 0.248470125803977 no 2524 0.272464835421555 3611 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_470 aa-861 153 µM -0.60625016073679 0.248157905519738 no 2525 0.272174324242026 3484 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3140 9094243 49.47 µM -0.60754801428711 0.247695122752295 no 2526 0.271743644293699 3574 19291112 SGTC_2466 5983409 37.09 µM -0.607924418420318 0.247560992531614 no 2527 0.271618801761933 3462 2879657 SGTC_2280 7785178 200 µM -0.60809176679527 0.247501371020438 no 2528 0.271563306243815 3491 2954328 SGTC_1125 tnp00248 1.32998 µM -0.60860509937073 0.247318532958857 no 2529 0.271393111815036 3557 24207736 SGTC_100 0086-0128 49.5915 µM -0.608947265929261 0.247196700681399 no 2530 0.271279696676951 3510 93297 SGTC_2630 antimycin a 100 µM -0.60936258628784 0.247048864296694 no 2531 0.271142065597088 3494 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_340 k038-0059 454 µM -0.612892967585205 0.245794110865029 no 2532 0.269973556753933 3521 23733424 SGTC_2170 morpholine 200 µM -0.613561144700431 0.24555701574936 no 2533 0.269752683058351 3533 121171 Reacts with secondary amines. SGTC_2516 gossypol 71.55 µM -0.615396644500927 0.244906342114466 no 2534 0.269146403426878 3579 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_9 0092-0002 10.449 µM -0.615881571027117 0.244734593649848 no 2535 0.268986342731042 3537 759368 SGTC_2994 9053520 71.4286 µM -0.616232797577233 0.244610238770645 no 2536 0.268870442505816 3517 4647384 SGTC_869 0564-0080 44.1 µM -0.616378005045602 0.244558836721561 no 2537 0.268822533244696 3504 6843321 SGTC_981 1488-1094 54.9 µM -0.616673842046261 0.244454131268912 no 2538 0.268724939052395 3529 3449522 SGTC_1132 3456-3614 2.5 µM -0.616710810705057 0.24444104866655 no 2539 0.268712744647295 3592 3125502 SGTC_3221 9128209 49.47 µM -0.617408115396298 0.244194354647261 no 2540 0.26848278525785 3543 16460723 SGTC_3032 9089427 49.47 µM -0.618936144758134 0.243654234693596 no 2541 0.267979213006092 3530 17173707 SGTC_3308 9128332 17.569 µM -0.619991735563027 0.243281486959682 no 2542 0.267631613996049 3564 17332805 YDL196W YDL196W SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.621084596363915 0.242895903496303 no 2543 0.267271981828079 3547 6708760 SGTC_847 0342-0274 5.54 µM -0.621937755162735 0.242595121739095 no 2544 0.266991398970822 3547 18097 SGTC_2678 equilin 100 µM -0.622041191573675 0.242558668870623 no 2545 0.266957391404087 3579 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2162 5663267 200 µM -0.62397108906683 0.241879082272436 no 2546 0.266323285986421 3556 6456493 SGTC_2282 7944268 200 µM -0.624004951655401 0.241867167261161 no 2547 0.26631216658159 3606 2970414 SGTC_2935 9038016 29.96 µM -0.624688594053508 0.241626686533108 no 2548 0.266087730269386 3558 6463195 SGTC_2406 ethylparaben 405.7 µM -0.626028298740262 0.241155803453242 no 2549 0.265648190010867 3343 8434 A possible steroid mimic. SGTC_1370 2001-0092 44.6 µM -0.626235676007146 0.241082958533283 no 2550 0.265580185059776 3645 790957 SGTC_255 tunicamycin 200.472 nM -0.62784875482742 0.24051674483854 no 2551 0.265051511911569 3514 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1910 st062352 60.4 µM -0.63046665238115 0.239599368719229 no 2552 0.264194657176289 3523 2245730 SGTC_514 4466-0038 2.65 nM -0.631230758050507 0.239331967721875 no 2553 0.263944826723738 3541 5722064 SGTC_508 roscovitine 141 µM -0.631384184753694 0.239278295260829 no 2554 0.263894677158065 3585 160355 A CDKinase inhibitor. SGTC_648 0375-0473 33.3 µM -0.632130843684796 0.239017189366897 no 2555 0.263650691079051 3566 1713139 SGTC_404 fumagillin 50 µM -0.633023925668391 0.238705084169501 no 2556 0.263359009490636 3529 12015870 A methionine aminopeptidase binder. SGTC_596 1155-0152 116 µM -0.633054299884362 0.23869447322019 no 2557 0.263349092135194 3577 280313 SGTC_1975 st070967 30.8 µM -0.634454543964712 0.238205591297171 no 2558 0.262892111540428 3597 261391 SGTC_1329 1447-1697 50.6 µM -0.635684937135295 0.237776464415973 no 2559 0.262490898046418 3566 2840515 SGTC_133 0724-0033 378.92 µM -0.64060201431424 0.236065765563575 no 2560 0.260890645262869 3490 280309 SGTC_1173 0443-0020 122 µM -0.641093982678347 0.235894978966204 no 2561 0.260730811739264 3580 5331295 SGTC_3322 9139058 2.11 µM -0.641167311488988 0.235869528735967 no 2562 0.26070699256742 3614 4908926 YPR165W RHO1 SGTC_2673 kobusone 100 µM -0.644304716553983 0.234782048490215 no 2563 0.259688928877381 3631 6710676 An epoxy ketone and protein crosslinker. SGTC_3206 9114350 49.47 µM -0.644787866191796 0.234614826883802 no 2564 0.259532333084932 3545 17087243 SGTC_499 genistein 192 µM -0.64517467190666 0.234480998100987 no 2565 0.259406998908363 3598 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1817 st052116 64.4 µM -0.645636112347905 0.234321402117871 no 2566 0.259257522228606 3604 4361398 SGTC_138 0850-0259 40.9225 µM -0.646331922433245 0.234080859658094 no 2567 0.259032209230799 3630 6813004 SGTC_2651 TUB2.036 5 µM -0.646921436140867 0.23387717105348 no 2568 0.25884139575205 3694 15992207 YFL037W TUB2 SGTC_864 0469-0573 172 µM -0.647343006247634 0.233731570522059 no 2569 0.258704986783224 3528 689425 SGTC_1510 1123-0200 71.5 µM -0.650552746754085 0.232624649841053 no 2570 0.257667620957806 3684 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_575 k072-0246 11.9 µM -0.650647753313004 0.232591930061463 no 2571 0.257636948440424 3607 6796779 SGTC_1053 3366-3204 134 µM -0.651468566366371 0.232309352752611 no 2572 0.257372030938403 3551 3632071 YPR165W RHO1 SGTC_2971 9092186 9.93 µM -0.651604716724143 0.232262499407716 no 2573 0.257328102086823 3516 25236400 SGTC_1002 4049-0206 172 µM -0.653420735116295 0.23163805706995 no 2574 0.256742537407133 3623 4662749 SGTC_2524 avocatin b 10.57 µM -0.654205946446472 0.231368350252468 no 2575 0.256489565510574 3544 6710748 SGTC_32 0928-0142 34.1 µM -0.655818288590313 0.230815087398817 no 2576 0.255970523867809 3584 2244242 SGTC_939 1165-0479 45.3 µM -0.655909446295676 0.230783829413961 no 2577 0.255941194955644 3557 1377347 SGTC_1228 0124-0032 52.5 µM -0.658221841005548 0.229991700210366 no 2578 0.255197796152685 3630 X1228 SGTC_812 4251-0442 148 µM -0.659343047947385 0.229608170290442 no 2579 0.254837752495779 3608 5723007 SGTC_3245 9134821 49.47 µM -0.659753692465296 0.229467791303665 no 2580 0.254705952267139 3552 17014901 SGTC_2263 7948595 193.29 µM -0.660431774272419 0.229236094093269 no 2581 0.254488393678393 3598 2971371 SGTC_1679 SEC14.276 6.7 µM -0.660705271351982 0.22914267862854 no 2582 0.254400671301271 3630 1005053 YMR079W SEC14 SGTC_1250 0485-0349 40.2 µM -0.661508139772239 0.228868574841616 no 2583 0.254143248144844 3595 6842794 YDL195W SEC31 SGTC_2054 5233173 129 µM -0.663136066087254 0.228313356926148 no 2584 0.253621706876474 3612 6889 SGTC_1920 st075728 45.7 µM -0.663518077896251 0.228183178347502 no 2585 0.253499402652133 3631 3400306 SGTC_859 0439-0102 54.6 µM -0.665300909922905 0.227576192891949 no 2586 0.25292902436053 3636 610143 SGTC_1856 st057054 55.7 µM -0.665416618299596 0.227536830101197 no 2587 0.252892029338803 3686 1266018 SGTC_866 0495-0101 262 µM -0.666125308789786 0.227295824613292 no 2588 0.252665504442972 3581 635694 SGTC_2608 thymoquinone 42.66 µM -0.666470439096732 0.22717850770991 no 2589 0.252555226152686 3551 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1625 st003711 30.1 µM -0.666613134920634 0.227130012433479 no 2590 0.252509638461562 3675 24207034 YER133W GLC7 SGTC_2837 9008476 45.46 µM -0.668316388000985 0.226551611415481 no 2591 0.251965827290795 3642 2992805 SGTC_201 4262-0159 12.803 µM -0.669393391293124 0.226186305648439 no 2592 0.251622283103327 3593 1341029 SGTC_3333 9141820 12.094 µM -0.670271892949154 0.225888575738873 no 2593 0.251342240608882 3610 1939433 SGTC_3235 9132602 49.47 µM -0.67223938459661 0.225222584643488 no 2594 0.250715655854881 3658 4912240 SGTC_2835 9006588 71.43 µM -0.672794350645387 0.225034931293214 no 2595 0.250539066160695 3631 2345538 SGTC_2078 5212016 200 µM -0.672821495919363 0.225025754804058 no 2596 0.250530430249959 3570 1899708 SGTC_1146 3579-1023 7 µM -0.673187179620501 0.22490215570615 no 2597 0.25041410818109 3665 X1146 SGTC_2575 plumbagin 510 nM -0.673361566374727 0.224843227488254 no 2598 0.250358646750575 3600 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2146 5545642 200 µM -0.674123314163848 0.224585922753512 no 2599 0.250116459175103 3655 825326 SGTC_249 wiskostatin 11.211 µM -0.674494360456869 0.224460650499628 no 2600 0.249998534969406 3644 2775510 A n-wasp and actin depolymerizer. SGTC_1050 3232-1156 69.3 µM -0.675527504770525 0.224112050419366 no 2601 0.249670341353766 3602 700529 SGTC_1029 k015-0030 64.7 µM -0.677565700921087 0.223425231636058 no 2602 0.249023549731025 3663 2208316 SGTC_1840 st055363 71 µM -0.678272549222603 0.223187322209924 no 2603 0.248799450183463 3590 676033 SGTC_1371 2421-0008 32.7 µM -0.678733061174231 0.223032401740391 no 2604 0.24865350702174 3623 2827552 SGTC_3247 9135149 49.47 µM -0.679506437857394 0.222772368521096 no 2605 0.248408514945899 3611 8934436 YOR116C RPO31 SGTC_2882 9058044 58.44 µM -0.679639692905708 0.222727581497394 no 2606 0.248366315097054 3602 18076804 SGTC_2072 5231554 129 µM -0.681209414114662 0.222200384596111 no 2607 0.247869496017983 3710 789545 SGTC_905 2-aminofluorene 215 µM -0.682567442936381 0.221744860496872 no 2608 0.247440106255914 3678 1539 An established DNA mutagen. YPR165W RHO1 SGTC_204 PMA1.184 62.41 µM -0.683185686233394 0.221537659780008 no 2609 0.247244758111724 3674 2252213 YGL008C PMA1 SGTC_2033 5192550 145 µM -0.684373948484608 0.221139731375853 no 2610 0.246869531087058 3638 182073 SGTC_3001 9076041 71.4286 µM -0.685145453644378 0.220881586797053 no 2611 0.246626070056905 3662 16004211 SGTC_2960 9079389 5.97 µM -0.687895204938418 0.219962928227442 no 2612 0.245759388195995 3633 16457355 SGTC_2438 5259590 200 µM -0.690447860725056 0.219112082545619 no 2613 0.244956293845496 3676 1201127 SGTC_1231 0242-0792 125 µM -0.691403431928095 0.218794061073999 no 2614 0.244656023985818 3659 3707635 SGTC_831 k061-1017 217 µM -0.692638737439154 0.218383335747697 no 2615 0.244268146923902 3709 1240153 SGTC_1275 0867-0008 21.1 µM -0.694982042199088 0.217605434510198 no 2616 0.243533277798851 3650 3422836 SGTC_1159 4092-0538 61.2 µM -0.695066372117182 0.217577469551684 no 2617 0.243506853900408 3705 717301 SGTC_2099 5377090 177.372 µM -0.695708253566264 0.217364680837892 no 2618 0.243305777823529 3664 2243829 SGTC_764 1951-2361 146 µM -0.695708512213475 0.217364595118548 no 2619 0.243305696817677 3647 5438930 SGTC_1455 4262-0120 131 µM -0.696516156430513 0.217097025608489 no 2620 0.243052821412469 3728 1529587 SGTC_352 k048-0007 5.11 µM -0.701313201231564 0.215511709580549 no 2621 0.241553788501645 3671 6811911 SGTC_3092 9117248 49.47 µM -0.70133603585019 0.215504179341891 no 2622 0.241546664916704 3725 17141857 SGTC_2773 thioridazine 9.09 µM -0.70279635588624 0.215022922393224 no 2623 0.241091334273455 3689 5452 An antipsychotic. SGTC_635 k038-0028 24.7 µM -0.70324061982184 0.214876636533587 no 2624 0.240952904547799 3701 4035102 SGTC_2105 5350118 200 µM -0.705115335041254 0.214259973110511 no 2625 0.240369231996988 3701 2133313 SGTC_63 0099-0242 26.702 µM -0.705136115319584 0.214253143479682 no 2626 0.240362766598149 3716 3898502 YLR359W ADE13 SGTC_1710 st031758 61.5 µM -0.70688209596808 0.213679763262623 no 2627 0.239819875563225 3702 5394341 SGTC_1692 fluoroquinolonic acid 71 µM -0.707400740290687 0.213509612772397 no 2628 0.239658738503752 3693 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2467 5474540 200 µM -0.707873027733638 0.213354739190656 no 2629 0.239512055433901 3671 5413519 SGTC_2888 9058547 12.99 µM -0.708227075156207 0.213238682110111 no 2630 0.239402127512312 3618 16476514 SGTC_1491 4138-0063 26.5 µM -0.709481821777871 0.212827671520022 no 2631 0.239012764128693 3654 23883227 SGTC_203 k066-0004 30.888 µM -0.710170812543977 0.212602179339416 no 2632 0.238799109115621 3755 6795412 SGTC_1513 0337-0559 19 µM -0.711896636747844 0.212037966242419 no 2633 0.23826439248652 3657 775073 SGTC_3272 9137413 49.47 µM -0.713680080026953 0.211455837098822 no 2634 0.237712513397401 3655 17614870 SGTC_3057 9095946 49.47 µM -0.716645451176 0.210489992459138 no 2635 0.236796446057189 3719 24540043 SGTC_2663 amphotericin b 100 µM -0.720016187199831 0.209395267880829 no 2636 0.235757514558419 3700 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_562 3772-2733 112 µM -0.720675726993326 0.209181459628569 no 2637 0.235554524984373 3727 2876874 YIL048W NEO1 SGTC_745 0469-0705 296 µM -0.721445162534078 0.208932188106425 no 2638 0.235317834206499 3784 3486736 SGTC_1337 1486-1011 40.3 µM -0.722483217107689 0.208596170375695 no 2639 0.23499872003674 3724 X1337 SGTC_1944 st076371 56.9 µM -0.724308515817915 0.208006095348194 no 2640 0.234438175028039 3731 24208455 SGTC_934 2950-0684 338 µM -0.727442706558761 0.206995188911269 no 2641 0.233477400408406 3737 1121253 SGTC_2676 harmalol 100 µM -0.727524550772123 0.206968829767719 no 2642 0.233452340661375 3710 5459187 A monoamine oxidase inhibitor SGTC_2708 st078559 56 µM -0.728887159176237 0.20653027340227 no 2643 0.233035345076933 3651 17250902 SGTC_2138 5575593 77.673 µM -0.729653202866498 0.206283963672473 no 2644 0.232801096426028 3712 762213 SGTC_1342 1486-1464 234 µM -0.730268150232812 0.206086362712885 no 2645 0.232613146261443 3759 3253938 SGTC_2912 7964298 10.93 µM -0.730693421228363 0.205949776110184 no 2646 0.232483217413587 3783 2975850 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.731436071449466 0.205711383890018 no 2647 0.232256419631506 3791 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1168 k815-0004 80.5 µM -0.731947133838446 0.205547426999412 no 2648 0.232100417942252 3707 642433 SGTC_3053 9095903 49.47 µM -0.732316072517998 0.205429113875588 no 2649 0.231987835747811 3776 17174018 SGTC_3113 9123498 49.47 µM -0.732625966080542 0.20532976689785 no 2650 0.231893294761337 3748 8897275 SGTC_1516 st013856 110 µM -0.732770566747991 0.205283419976317 no 2651 0.231849187959063 3738 5281404 A mutagen and neurotoxin. SGTC_2838 9002687 71.43 µM -0.733420631757963 0.205075140099929 no 2652 0.23165095968755 3725 6457060 SGTC_2855 9016525 58.44 µM -0.733776835163661 0.204961066336322 no 2653 0.231542380489192 3730 43811474 SGTC_215 1287-0124 461.5 µM -0.736138314205657 0.204205759711574 no 2654 0.230823263931023 3752 5560863 SGTC_1024 4507-0395 26 µM -0.73671535986099 0.204021447023741 no 2655 0.230647732063801 3757 4201836 SGTC_1678 st019265 80.2 µM -0.737331692392459 0.203824695319495 no 2656 0.230460331896561 3734 5367020 SGTC_2665 lovastatin 100 µM -0.737616883121935 0.203733692229396 no 2657 0.230373646495475 3753 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3148 9097893 49.47 µM -0.738437918724538 0.203471838713177 no 2658 0.230124189707629 3711 17174100 SGTC_1550 gossypolone 36.6 µM -0.73980452390694 0.203036431732745 no 2659 0.229709306805813 3738 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1334 1486-0610 236 µM -0.740412818974564 0.202842805069569 no 2660 0.229524771443662 3803 3742339 SGTC_2164 5685496 200 µM -0.741920212373123 0.202363461642864 no 2661 0.229067839374726 3698 759046 SGTC_2853 9015042 58.44 µM -0.743114492459521 0.201984168061396 no 2662 0.228706183088404 3695 6457456 SGTC_3121 9125696 49.47 µM -0.744667357750376 0.201491627609969 no 2663 0.228236418522384 3805 1235365 SGTC_406 estrone 100 µM -0.745255854163987 0.201305155533737 no 2664 0.228058531543993 3750 5870 A steroid. SGTC_1842 st055362 61.2 µM -0.745661359135816 0.201176726690656 no 2665 0.227936003451386 3740 676032 SGTC_363 0455-0021 3.06 µM -0.74653076209585 0.200901540801915 no 2666 0.227673427990638 3753 4597466 SGTC_1404 3909-7820 48.3 µM -0.746686076899337 0.200852403909431 no 2667 0.227626538036839 3711 23741373 SGTC_3049 9092223 49.47 µM -0.746817766449498 0.200810746980736 no 2668 0.227586784869872 3724 8623917 SGTC_33 0986-0033 35.816 µM -0.746913482093557 0.200780472815335 no 2669 0.227557893610915 3680 2848082 SGTC_2136 5328288 199.296 µM -0.749099753974299 0.200089716964845 no 2670 0.226898541657831 3761 262395 SGTC_1981 st071826 47 µM -0.749205253927219 0.200056420268165 no 2671 0.226866751484217 3751 11838600 SGTC_2428 5615643 7.78 µM -0.751497417371905 0.199333816342396 no 2672 0.226176677238759 3789 2253075 SGTC_94 0334-0113 514.748 µM -0.753076888309065 0.198836804375824 no 2673 0.225701855872837 3750 6795178 SGTC_2777 climbazole 1.536 µM -0.754197831722659 0.198484530849648 no 2674 0.225365219696321 3708 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_860 0443-0016 25.1 µM -0.754956426221133 0.198246344749414 no 2675 0.225137563743213 3786 5337942 SGTC_3201 9113999 49.47 µM -0.755166815357429 0.19818031661982 no 2676 0.225074448564777 3799 16649224 SGTC_49 0717-0965 32.132 µM -0.758369865657595 0.197176717833431 no 2677 0.224114796316843 3819 5889349 YGL099W LSG1 SGTC_1621 st003705 32.4 µM -0.759287565352748 0.196889746405572 no 2678 0.22384027713168 3789 24207032 SGTC_142 0335-0849 62.6745 µM -0.760814642914425 0.196412778891528 no 2679 0.223383893532231 3778 3889043 YPR107C YTH1 SGTC_3298 9116858 71.43 µM -0.761281716752783 0.196267032986106 no 2680 0.223244409287451 3797 2506942 SGTC_447 ml7 120 µM -0.761328328725066 0.196252491766913 no 2681 0.223230492077197 3791 4216 Selective myosin light chain kinase inhibitor. SGTC_1266 0828-0227 32.9 µM -0.7625530922927 0.195870644733422 no 2682 0.22286498424205 3807 3913820 SGTC_2184 6075246 200 µM -0.763911150613418 0.195447767636618 no 2683 0.222460096012605 3832 2267320 SGTC_1103 duloxetine 36.1 µM -0.764019859751525 0.195413941380665 no 2684 0.222427703876587 3875 60835 A selective serotonin reuptake inhibitor. SGTC_329 k048-0121 21.3 µM -0.764066993845898 0.195399276102119 no 2685 0.222413660134423 3767 6832902 SGTC_661 1304-0007 33.6 µM -0.764843220654499 0.195157857455365 no 2686 0.22218245382936 3784 3117130 SGTC_1691 st019933 84.6 µM -0.767740038895454 0.194258503604471 no 2687 0.221320821931431 3742 6176082 SGTC_1247 0448-0043 5.84 µM -0.76847720703796 0.194030043921979 no 2688 0.221101863469592 3852 3089013 YGL099W LSG1 SGTC_2623 humulene 100 µM -0.769701751256527 0.193650900954093 no 2689 0.220738415512487 3728 6187145 An anti-inflammatory. SGTC_1060 3448-7350 82 µM -0.770861447757943 0.193292252946286 no 2690 0.220394530207551 3726 570178 SGTC_350 k064-0020 19.8 µM -0.771057791128309 0.193231571899507 no 2691 0.220336338834475 3751 2790705 SGTC_224 benfluorex 43.875 µM -0.772385914202402 0.192821413234078 no 2692 0.219942947007593 3769 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1183 1254-0324 198 µM -0.773406843236389 0.192506485857623 no 2693 0.219640820643937 3855 5799357 SGTC_331 k048-0133 24.5 µM -0.774118312000339 0.192287204142854 no 2694 0.219430414704454 3767 6813582 SGTC_787 4152-0075 138 µM -0.774179486454201 0.192268356705933 no 2695 0.219412328709316 3800 9566539 SGTC_2695 st077686 51.995 µM -0.775055654471989 0.19199853924453 no 2696 0.219153386958149 3847 2876092 SGTC_2408 sulbentine 18.36 µM -0.776241693325732 0.191633665891816 no 2697 0.218803146357012 3796 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_469 w7 172 µM -0.776354209320851 0.19159907350702 no 2698 0.21876993680312 3832 45115570 A P450 inhibitor. SGTC_1659 st012954 42.1 µM -0.776885459101837 0.191435795538122 no 2699 0.218613175452889 3793 24207262 SGTC_2203 7227154 166.4 µM -0.777496624122098 0.191248061368167 no 2700 0.218432912703022 3794 896304 SGTC_643 k048-0106 28.4 µM -0.780337266555719 0.190376971297228 no 2701 0.217596191398703 3826 6763920 SGTC_2216 7189485 200 µM -0.780614718357856 0.190292020834538 no 2702 0.217514566258092 3788 731273 SGTC_664 1222-0054 14.9 µM -0.781048757827134 0.190159172922931 no 2703 0.217386909148881 3761 6813991 SGTC_1039 k821-0043 94 µM -0.782734662292656 0.18964370328622 no 2704 0.216891471470224 3762 15992768 SGTC_3280 9140961 49.47 µM -0.783739994997601 0.189336729723394 no 2705 0.216596344724842 3843 4901226 SGTC_589 1227-0070 34.1 µM -0.784224490960116 0.189188900468002 no 2706 0.216454198471259 3842 2841384 SGTC_3335 9143315 29.6265 µM -0.784370274005537 0.18914443310466 no 2707 0.216411437756543 3811 4899691 SGTC_1838 st055369 84.5 µM -0.785665752376529 0.188749563573783 no 2708 0.216031666124478 3795 676036 SGTC_2961 9083290 32.55 µM -0.78787893818205 0.18807614783111 no 2709 0.215383760966277 3773 17741490 SGTC_312 4092-0653 6.84 µM -0.789697523569202 0.187523910289675 no 2710 0.214852218976965 3802 1148278 SGTC_960 1222-0186 7.7 µM -0.789820416959522 0.187486628263875 no 2711 0.214816326809861 3859 3126296 SGTC_2123 5259487 200 µM -0.790574863614625 0.187257853048442 no 2712 0.214596059935618 3806 2173474 SGTC_2388 9080168 200 µM -0.791111526309506 0.187095222828023 no 2713 0.214439456808649 3791 15943073 SGTC_2587 piperic acid 92.2 µM -0.791128580996544 0.187090056009704 no 2714 0.214434481183292 3833 5370536 SGTC_391 gliotoxin 8.33 µM -0.79124888048916 0.187053613073805 no 2715 0.214399386274613 3921 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2813 7971799 71.43 µM -0.792776165957174 0.186591326571191 no 2716 0.213954122549731 3903 2234054 SGTC_566 0958-0068 16.5 µM -0.793075556203769 0.186500788615511 no 2717 0.213866901678629 3763 6815365 SGTC_2827 7993847 71.43 µM -0.796538988963805 0.185455398226051 no 2718 0.212859411560115 3871 2985692 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.801207834869241 0.184051939332718 no 2719 0.211505668103581 3896 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_972 1319-0219 195 µM -0.804092121454651 0.183188233628573 no 2720 0.21067188715687 3822 23903702 SGTC_310 1273-0058 1.06 µM -0.804712593894189 0.183002762782328 no 2721 0.210492775199277 3788 2734232 SGTC_1673 st016611 27.3 µM -0.805181078246369 0.182862801685763 no 2722 0.210357596924603 3888 5226799 SGTC_2361 9034121 116 µM -0.808452040296892 0.181887454624569 no 2723 0.209415202160742 3849 6496917 SGTC_980 1473-0395 201 µM -0.810452683926481 0.181292502308024 no 2724 0.208840024442299 3759 768876 SGTC_1042 0350-0096 82 µM -0.810570863945982 0.18125739604161 no 2725 0.208806077260179 3849 3122515 SGTC_91 0417-1751 58.384 µM -0.810871132740659 0.181168218082857 no 2726 0.208719839748553 3941 6795624 SGTC_339 3091-4833 71.4 µM -0.811952424156599 0.180847309009264 no 2727 0.208409465670212 3774 3240077 SGTC_687 k029-0044 34.9 µM -0.81275990265392 0.180607895530234 no 2728 0.208177864542367 3896 5829338 SGTC_1825 st052143 62.6 µM -0.816905013436798 0.179382021467614 no 2729 0.206991356264035 3849 674173 SGTC_654 1124-0271 80.9 µM -0.817538863195512 0.179195029099138 no 2730 0.206810274698926 3865 5403748 SGTC_2276 7947513 42.08 µM -0.818829965675826 0.178814519615444 no 2731 0.20644171586967 3780 2105100 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.821961168915939 0.177893816068431 no 2732 0.205549498740567 3905 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_473 2-arachidonoylglycerol 10 µM -0.823589481956468 0.17741620836139 no 2733 0.205086427168032 3735 5282280 An endocannabinoid. SGTC_1056 3448-1962 115 µM -0.824664969569996 0.177101196670047 no 2734 0.204780912423544 3865 715507 SGTC_95 0471-0001 561.058 µM -0.824787376170129 0.177065366030521 no 2735 0.204746157434623 3838 4015405 SGTC_2511 berberine 10.47 µM -0.825526470023649 0.176849117131204 no 2736 0.204536380573597 3854 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2241 6772625 37.8075 µM -0.827006875980209 0.176416472588446 no 2737 0.204116582107082 3778 2285411 SGTC_2333 9017922 200 µM -0.828173755685869 0.176075927531226 no 2738 0.203786052205002 3926 3163164 SGTC_3259 9138485 49.47 µM -0.829640375202941 0.175648496337632 no 2739 0.203371070945888 3926 17646153 SGTC_912 3474-0017 2.18 µM -0.830847700643636 0.175297127550638 no 2740 0.203029835847037 3908 3360550 SGTC_725 1497-0963 19 µM -0.832123179988743 0.174926408380057 no 2741 0.202669709558642 3923 3549977 SGTC_1986 st071812 45 µM -0.832437092344725 0.17483524582752 no 2742 0.202581136283347 3808 11838594 SGTC_260 nsc-65238 3.989 µM -0.833125833545517 0.174635335787725 no 2743 0.202386882675363 3845 3246252 SGTC_1156 4092-0367 4.88 µM -0.833221567191281 0.174607560186629 no 2744 0.202359890633649 3892 1357585 SGTC_2580 diallyl disulphide 81.36 µM -0.833583102896104 0.174502691630071 no 2745 0.202257975285933 3902 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_673 1082-0474 110 µM -0.833819850880114 0.174434041200234 no 2746 0.202191253694741 3890 3098046 SGTC_2197 6588183 93.1375 µM -0.836062808046787 0.17378449646177 no 2747 0.201559785024204 3822 884136 SGTC_1295 1013-0063 9.78 µM -0.836253875696704 0.17372923580385 no 2748 0.201506047655776 3854 6826038 SGTC_991 3996-0057 64.7 µM -0.838120507242786 0.173189956081524 no 2749 0.200981513262118 3939 715343 SGTC_1000 4048-0884 8.67 µM -0.838130306105368 0.173187127954131 no 2750 0.200978761887401 3909 13040088 SGTC_2302 7771753 200 µM -0.839377649097515 0.172827362581756 no 2751 0.20062871108565 3901 2203047 SGTC_907 3448-6986 75.5 µM -0.842098353352379 0.172044296263989 no 2752 0.199866451450625 3905 590582 SGTC_1646 st011709 75.6 µM -0.842982535356669 0.171790301582087 no 2753 0.199619105693102 3828 5757843 SGTC_3029 9088683 49.47 µM -0.843073839891531 0.171764086619697 no 2754 0.199593574175831 3902 25236615 SGTC_604 1000-0114 314 µM -0.843193922534227 0.171729612901869 no 2755 0.199559998418764 3885 1572745 SGTC_1955 wogonin 32.4 µM -0.844490162992367 0.171357765325914 no 2756 0.199197779003233 3988 5281703 A flavanone. SGTC_233 rapamycin 362 pM -0.845541228056472 0.171056628446589 no 2757 0.198904361955934 3894 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3241 9133421 49.47 µM -0.847688538568155 0.170442463100262 no 2758 0.198305725530076 3893 17018221 SGTC_105 0111-0055 734.78 µM -0.848515618378619 0.170206282166222 no 2759 0.198075439052761 3914 5179370 SGTC_2649 anisomycin 9.56 µM -0.849232048332094 0.170001867983898 no 2760 0.197876091748965 3886 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_668 1682-0499 62.6 µM -0.849455150724931 0.169938243811252 no 2761 0.197814038056488 3917 682214 SGTC_2684 capsaicin 100 µM -0.849928416117347 0.169803328886785 no 2762 0.197682442965553 3925 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2881 9058953 51.95 µM -0.851158227809544 0.169453064696643 no 2763 0.197340731805501 3871 17122249 SGTC_2387 9077560 195.08 µM -0.852869399579591 0.168966475705853 no 2764 0.196865866439216 3882 5303272 SGTC_2404 5161160 200 µM -0.853178523194043 0.168878669089167 no 2765 0.196780155730809 3870 2831543 SGTC_1052 3253-3998 198 µM -0.853378944063918 0.168821755173964 no 2766 0.196724597111197 3856 5450317 SGTC_441 propafenone 146 µM -0.853949157780907 0.168659897864164 no 2767 0.196566580282224 3886 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_559 1550-0661 158 µM -0.854445793056006 0.168519007365988 no 2768 0.196429016084004 3972 5830875 SGTC_2962 9082311 13.18 µM -0.854688255465951 0.168450250683619 no 2769 0.196361877039874 3915 16459453 SGTC_2019 4016004 108 µM -0.856296368443344 0.167994684019837 no 2770 0.195916934746102 3942 45595336 SGTC_1991 st073000 8.92 µM -0.857981541861247 0.167518138393663 no 2771 0.195451327901316 4005 4301969 YIL048W NEO1 SGTC_2400 5203494 178.7 µM -0.858959450298064 0.167241998027344 no 2772 0.195181444045513 3838 6777674 SGTC_1162 k048-0130 20.1 µM -0.859817554803075 0.166999929558003 no 2773 0.194944810422062 3882 6797406 SGTC_1077 5-fluorocytosine 377 nM -0.860632179646497 0.166770335738409 no 2774 0.194720328373762 3929 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1386 3228-0095 33.8 µM -0.861561729416876 0.166508600385499 no 2775 0.194464369232835 3942 870181 SGTC_173 1273-0061 2.693 µM -0.862722381824409 0.166182165425884 no 2776 0.194145061749339 3926 2847414 YPL266W DIM1 SGTC_1154 4088-0362 150 µM -0.862724412795918 0.166181594575138 no 2777 0.194144503288125 3913 6618304 SGTC_998 3996-0085 177 µM -0.866171488927725 0.165214541075639 no 2778 0.193198063016245 3949 715391 SGTC_2224 6650123 117.647 µM -0.866974819143823 0.164989696667699 no 2779 0.192977903402154 3887 2908370 SGTC_1999 st074831 12.5 µM -0.867539309242651 0.164831819899237 no 2780 0.192823291688693 3901 17112523 SGTC_1478 0453-0656 35.7 µM -0.869152323024694 0.164381231169425 no 2781 0.192381910518172 3940 5258496 SGTC_2444 5485484 36.41 µM -0.871100779580912 0.163838003808195 no 2782 0.191849564254463 4010 6790631 SGTC_455 paf C-16 10 µM -0.871330446878498 0.163774049684736 no 2783 0.191786875324694 3904 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_234 nsc-17383 10.7 µM -0.871449867476933 0.16374080172586 no 2784 0.191754283784028 3920 408974 SGTC_1425 4048-4433 7.33 µM -0.871718998918346 0.163665888747858 no 2785 0.191680846508769 3974 23734946 SGTC_3184 9108758 49.47 µM -0.874316411992235 0.162944040350591 no 2786 0.190972982002514 3946 902885 SGTC_1259 0671-0132 43 µM -0.874971871252358 0.162762208904964 no 2787 0.19079460551308 3861 X1259 SGTC_2594 a-mangostin 100 µM -0.87587460052976 0.162511998219168 no 2788 0.190549104458511 3984 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2900 5328528 85.29 µM -0.877812540808018 0.161975702571356 no 2789 0.190022728828843 3962 795359 SGTC_449 xestospongin c 11.1929 µM -0.879327778774394 0.161557187396788 no 2790 0.189611789139998 3953 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1480 1070-0044 41.2 µM -0.881077757319597 0.161074713937681 no 2791 0.189137867596204 3952 3124987 SGTC_2157 5649910 96.377 µM -0.882707550684083 0.16062622231598 no 2792 0.188697150735022 3925 2858091 SGTC_3198 9112019 49.47 µM -0.882838012737959 0.160590356652462 no 2793 0.188661899520466 3997 45595555 SGTC_2195 6536160 144.242 µM -0.884962640519599 0.160007006005967 no 2794 0.188088390631253 3874 3834386 SGTC_1990 st072050 59.8 µM -0.885880583861219 0.159755399155931 no 2795 0.187840939920701 3947 17233948 SGTC_3078 9116413 49.47 µM -0.890427525511331 0.158512908373157 no 2796 0.186618183936357 3861 17177322 SGTC_1461 k072-0203 53.8 µM -0.890924552051217 0.15837747690502 no 2797 0.186484823836598 3875 5418714 SGTC_308 4092-1169 104 µM -0.891613548136266 0.158189862516494 no 2798 0.186300052915803 3898 2268590 YDL196W YDL196W SGTC_1957 st077035 62.4 µM -0.891855006713118 0.158124147610135 no 2799 0.186235326824281 3977 705593 SGTC_927 2425-1185 123 µM -0.892180155815123 0.158035683964091 no 2800 0.186148188426327 3920 730375 SGTC_3320 9137005 35.139 µM -0.892860000653654 0.157850822894662 no 2801 0.185966074945945 3981 4908713 SGTC_593 1203-0218 61.7 µM -0.892884949935436 0.157844041474253 no 2802 0.18595939375756 4006 3666956 SGTC_2927 9011802 47.9 µM -0.893047034252075 0.157799990280215 no 2803 0.185915992691345 3989 43912568 SGTC_1459 k035-0031 35.7 µM -0.894076278319102 0.15752045129073 no 2804 0.185640540208577 3783 3877128 YMR208W ERG12 SGTC_2513 baicalein 25.65 µM -0.895866188677828 0.157035093569027 no 2805 0.185162117100413 3972 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1942 st076330 65.2 µM -0.896132014679964 0.156963095337124 no 2806 0.185091130137548 3973 24208414 SGTC_2008 4012253 172 µM -0.899105201042246 0.156159296050911 no 2807 0.184298314015329 3972 603940 SGTC_2553 4-methylesculetin 85.09 µM -0.899689757387102 0.156001581164583 no 2808 0.184142687854565 4004 5319502 SGTC_1448 4255-0083 152 µM -0.899993145327146 0.155919767673522 no 2809 0.184061949279725 4043 5399660 SGTC_1094 duloxetine 25.4 µM -0.901345302422656 0.155555480520333 no 2810 0.183702376942993 3966 60834 A selective serotonin reuptake inhibitor. SGTC_1902 st060212 70.5 µM -0.901838595476543 0.155422721411072 no 2811 0.183571307029592 3970 688944 SGTC_2183 6420625 130.508 µM -0.902419017989923 0.155266609063364 no 2812 0.183417161125679 3949 2897619 SGTC_2463 5473429 200 µM -0.907588240203719 0.153880844723028 no 2813 0.182047904866431 3976 5399405 SGTC_3046 9092212 49.47 µM -0.911377120633969 0.152870336608726 no 2814 0.181048352201462 4033 25236637 SGTC_2622 2-methoxyxanthone 59.94 µM -0.911922979973049 0.152725117409514 no 2815 0.180904631782207 4000 71034 A hepatoprotective. SGTC_1645 Cervolide 78 µM -0.913584218437761 0.152283728385411 no 2816 0.18046768100646 3958 23173 A fragrance. SGTC_1059 3448-6867 171 µM -0.914751531542433 0.151974081820864 no 2817 0.18016104239258 3897 3934407 SGTC_209 4077-0173 175.592 µM -0.914756122424526 0.151972864849694 no 2818 0.180159837071043 3959 15993494 SGTC_2485 5633444 17.78 µM -0.915224425175365 0.151848759110316 no 2819 0.180036912262596 4015 5724239 SGTC_629 3448-6466 76.7 µM -0.917160336503085 0.151336434549847 no 2820 0.179529313820157 3984 573744 SGTC_1260 0700-1617 7.75 µM -0.917527985637925 0.151239268978061 no 2821 0.179433017475868 4021 2853078 SGTC_423 5-fluorouracil 457 µM -0.919768781707328 0.150647948941434 no 2822 0.178846800212439 3945 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_130 0136-0219 337.655 µM -0.921376185310402 0.150224723422302 no 2823 0.178427028891515 3853 234244 SGTC_556 4058-0063 51.5 µM -0.922775552144022 0.149856919342546 no 2824 0.178062091922029 4038 6615692 SGTC_515 4092-1064 102 µM -0.924896907671897 0.149300496867912 no 2825 0.177509767655728 4030 717353 SGTC_1898 st060199 18.6 µM -0.924898140651241 0.149300173864335 no 2826 0.177509446947263 3965 688866 SGTC_924 2046-0044 21.3 µM -0.92545048583611 0.149155522925899 no 2827 0.177365814024747 3995 3623589 SGTC_1983 st071813 46.9 µM -0.927433083134171 0.14863708151016 no 2828 0.176850860175087 4066 11838595 SGTC_1291 0993-0025 5.79 µM -0.928495999897098 0.148359629593251 no 2829 0.176575170894529 4002 4353356 SGTC_1454 4239-0054 42.6 µM -0.929172638087953 0.148183188083573 no 2830 0.176399812549157 4121 1340767 SGTC_1276 0871-0068 94.2 µM -0.929298813309842 0.148150301921935 no 2831 0.176367125023048 4012 3414906 SGTC_1729 st035615 45.989 µM -0.930906012448365 0.147731830732072 no 2832 0.175951092066106 4049 17385451 SGTC_3082 9117008 49.47 µM -0.932728801800259 0.147258184538573 no 2833 0.175480005049209 4080 41448529 SGTC_2987 9018338 71.43 µM -0.934657743569277 0.146758064639215 no 2834 0.174982355203574 4056 5055682 SGTC_1839 st053978 48 µM -0.935237617019967 0.14660794293531 no 2835 0.174832928234267 4019 3788398 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.936212184406947 0.146355872321939 no 2836 0.174581975506994 4050 6708561 SGTC_445 e6 berbamine 66 µM -0.937674258058421 0.145978254882787 no 2837 0.174205918339795 4053 6610268 A calcium/calmodulin antagonist. SGTC_2598 perillyl alcohol 100 µM -0.939289435552448 0.145561856212363 no 2838 0.173791080582099 4061 10819 An apoptosis inducer. SGTC_2414 st077232 92.9 µM -0.939363423990008 0.145542800872976 no 2839 0.173772092657537 3970 729801 SGTC_2529 gangaleoidin 93.61 µM -0.939911943987506 0.145401584702211 no 2840 0.17363136511279 4039 4565183 SGTC_877 0771-0151 33.1 µM -0.941233905521401 0.14506162526556 no 2841 0.173292502528849 4048 6166523 SGTC_2112 5488546 200 µM -0.942800215672258 0.144659521423764 no 2842 0.172891550699449 3993 600757 SGTC_486 niguldipine 82 µM -0.943284988735431 0.144535222555818 no 2843 0.172767575980995 4062 1236 A calcium channel blocker. SGTC_1555 citronellol 128 µM -0.943617289267145 0.144450060186693 no 2844 0.172682626969146 3972 8842 A terpine precursor. SGTC_106 0092-0003 11.579 µM -0.943763124264751 0.144412696101035 no 2845 0.17264535424911 3920 1072148 SGTC_1134 3477-0009 42.5 µM -0.945302099354898 0.144018795483779 no 2846 0.172252333472669 4142 3973534 SGTC_1226 3909-7979 35.4 µM -0.947506469437736 0.143455850363107 no 2847 0.171690380604863 4034 6615510 SGTC_1405 3909-7894 12 µM -0.948473823848711 0.143209280056028 no 2848 0.171444146251659 4032 7104060 SGTC_3104 9120930 49.47 µM -0.948475514640577 0.143208849338496 no 2849 0.17144371606826 4053 17014836 SGTC_1744 st037937 38.9 µM -0.952873161517361 0.142091539296826 no 2850 0.170327169904989 4121 1016152 SGTC_773 4358-1457 44.6 µM -0.953491184488294 0.141934992369764 no 2851 0.170170630312609 3994 1186886 SGTC_569 4130-2812 160 µM -0.955637809001555 0.141392153896678 no 2852 0.169627626330154 3838 743552 SGTC_2377 9073351 62.6 µM -0.956612679177963 0.141146093907918 no 2853 0.169381393381912 4007 7337946 YHR072W ERG7 SGTC_304 1310-0298 97 µM -0.960355344026142 0.140204132922922 no 2854 0.168438202405651 3884 1550234 SGTC_3228 9131799 49.47 µM -0.960621261617902 0.140137369132252 no 2855 0.168371317117693 4041 17015818 SGTC_994 3910-0338 138 µM -0.960759264645172 0.140102729298507 no 2856 0.168336612449861 4133 3479481 SGTC_420 mitomycin C 81.9 mM -0.961649380551199 0.139879443049111 no 2857 0.168112878801367 4031 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_888 0916-0002 6.97 µM -0.962356124623394 0.139702328111882 no 2858 0.16793537262116 4095 2802138 YIL048W NEO1 SGTC_1864 st057645 30.4 µM -0.963325189269187 0.13945972179552 no 2859 0.167692178075563 4080 688666 SGTC_2368 9071271 200 µM -0.963377770131251 0.139446566324974 no 2860 0.167678988976702 4049 27209959 SGTC_1347 1493-0251 600 nM -0.963969163049582 0.139298660893482 no 2861 0.167530693192153 4096 3986378 SGTC_1753 st043925 64 µM -0.964850748374754 0.139078377511929 no 2862 0.167309786594798 4101 670181 SGTC_2512 diallyl trisulfide 49.23 µM -0.969263880856785 0.137979225304524 no 2863 0.166206772807483 4069 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1396 3511-0007 98.6 µM -0.970053972472082 0.13778306903401 no 2864 0.166009794983128 4056 X1396 SGTC_3120 9124077 49.47 µM -0.97009996963627 0.137771655169062 no 2865 0.165998332073785 4153 18774327 YGL155W CDC43 SGTC_1361 1608-0041 5.61 µM -0.970730239005925 0.137615323351453 no 2866 0.165841314767974 4022 X1361 SGTC_1594 piperine 70.1 µM -0.971472521425218 0.137431363174752 no 2867 0.165656515109725 4033 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_402 epigallocatechin gallate 10 µM -0.974879483117078 0.136589168813913 no 2868 0.164810022180026 4005 65064 An antioxidant. SGTC_2031 5180455 200 µM -0.974882795318435 0.136588351765136 no 2869 0.164809200596868 3999 29949 SGTC_3109 9122853 49.47 µM -0.975454703470854 0.136447324444241 no 2870 0.164667380004181 4110 1234709 SGTC_2830 7992007 71.43 µM -0.979317497967376 0.135497403145824 no 2871 0.163711563639536 3951 1952075 SGTC_3022 9087993 49.47 µM -0.980225045792316 0.135274881999786 no 2872 0.163487522015265 4124 17173644 SGTC_726 3448-4391 34.2 µM -0.982014038615208 0.134836973802694 no 2873 0.163046466057629 4186 1356692 SGTC_211 3455-0679 143.504 µM -0.983924718940564 0.134370354163348 no 2874 0.162576264376825 4115 748649 SGTC_2656 pseudo-anisatin 100 µM -0.985141786323127 0.134073704994852 no 2875 0.162277215190881 4099 6708809 A neurotoxin. SGTC_259 usnic acid 108.925 µM -0.98578065278958 0.133918167287918 no 2876 0.162120380861939 4166 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_48 0382-0018 55 µM -0.985894986946737 0.133890344710525 no 2877 0.16209232356532 4102 762596 SGTC_3331 9141060 1.957 µM -0.986339643793674 0.133782177724876 no 2878 0.16198323602949 4030 4906567 YPR165W RHO1 SGTC_86 0417-1630 471.922 µM -0.986402456265199 0.133766902840223 no 2879 0.161967830119713 4084 3634867 SGTC_1018 4259-0013 28.1 µM -0.991578243077383 0.132512360893427 no 2880 0.160701653460694 4146 6801262 SGTC_1807 st050092 58.9 µM -0.992096721187567 0.132387136888148 no 2881 0.160575172918419 4103 5008496 SGTC_2178 5812956 200 µM -0.994337728071283 0.131846822035903 no 2882 0.160029236902548 4039 5403383 SGTC_849 0386-0493 241 µM -0.99511863153891 0.131658901299978 no 2883 0.159839284993112 4051 726119 SGTC_982 1491-0518 27.5 µM -0.996090736115897 0.131425227291589 no 2884 0.159603030281056 4009 3091256 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.996497116434903 0.131327626714265 no 2885 0.15950433371635 4072 2346 DNA damaging agent; causes G2/M arrest. SGTC_620 0109-0052 432 µM -0.997583632404056 0.131066923431651 no 2886 0.159240650561912 4076 493037 SGTC_1563 conessine 56.1 µM -1.00024531373589 0.130429779721199 no 2887 0.158595902469806 4158 441082 An anti-amoebic, histamine inhibitor. SGTC_1676 st018489 23.4 µM -1.00293126014626 0.129789002412007 no 2888 0.157947014329464 4116 3696235 SGTC_3288 9119690 36.221 µM -1.00312482368561 0.129742908955902 no 2889 0.157900319442693 4090 17595618 YKL019W RAM2 SGTC_2313 7726885 200 µM -1.00639740568277 0.12896532189739 no 2890 0.157112220553282 4138 726423 SGTC_3351 9150312 21.596 µM -1.00699529012188 0.128823610510886 no 2891 0.156968518772095 4017 4904905 SGTC_2940 9060638 45.86 µM -1.0082597462223 0.128524263289568 no 2892 0.156664891093695 4082 4027022 SGTC_40 0327-0103 19.753 µM -1.00847948009532 0.128472292790915 no 2893 0.156612166924207 3966 409036 SGTC_2788 5282734 71.43 µM -1.00853401706193 0.128459396204929 no 2894 0.156599082830207 4200 743706 SGTC_2023 5144124 124 µM -1.00875663203222 0.128406762827052 no 2895 0.156545682204673 4076 2830192 SGTC_1721 st082152 9.2685 µM -1.01076203418127 0.127933295765524 no 2896 0.156065169144988 4032 5296051 SGTC_2856 9022925 19.48 µM -1.01209890951677 0.127618339736867 no 2897 0.155745381873028 4158 4944862 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.01256338179399 0.127509040450205 no 2898 0.155634378990888 4117 551469 SGTC_2473 5854593 8.94 µM -1.01286770421762 0.12743746281872 no 2899 0.155561678159178 3993 2872951 SGTC_2700 st077718 96.8 µM -1.01544818241764 0.126831648859647 no 2900 0.154946117608437 4099 904970 SGTC_2683 piperine 63.03 µM -1.01666125063104 0.126547553058922 no 2901 0.154657302702817 4087 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2850 9015429 58.44 µM -1.01869513116793 0.126072221474594 no 2902 0.15417386238734 4144 6457570 SGTC_2688 kanamycin b 96.69 µM -1.0190705570489 0.125984618180594 no 2903 0.154084735468688 4171 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2875 9039966 71.43 µM -1.02127825990498 0.125470323160134 no 2904 0.153561311708189 4125 6463691 SGTC_1393 3470-5649 58.2 µM -1.02277242456542 0.125123082821896 no 2905 0.153207729453447 4085 4108395 SGTC_1632 st005650 90 µM -1.02775212179114 0.12397066075752 no 2906 0.152033221559278 4150 2759605 SGTC_3191 9110352 49.47 µM -1.02843129355098 0.123814061534374 no 2907 0.151873497252917 4065 17122424 SGTC_2732 terfenadine 20 µM -1.0284755355526 0.1238038652935 no 2908 0.151863096503586 4167 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2985 9022375 71.43 µM -1.02959631249503 0.12354576127303 no 2909 0.151599773500877 4194 4939335 SGTC_544 k015-0020 52.4 µM -1.03259131504767 0.12285789120799 no 2910 0.150897597120299 4128 3008304 SGTC_1261 0712-0010 12.7 µM -1.0342365263064 0.122481176151447 no 2911 0.150512801095395 4167 2840123 SGTC_1921 5740136 50 µM -1.03476459659833 0.122360432370551 no 2912 0.150389430207719 4088 1774243 SGTC_2558 carylophyllene oxide 100 µM -1.03480548388615 0.122351086938744 no 2913 0.150379880690212 4248 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2440 5628896 157.78 µM -1.03573128805035 0.122139613942475 no 2914 0.150163760674774 4105 5522048 SGTC_2731 amoxapine 43.43 µM -1.03805015271844 0.121611063679727 no 2915 0.149623353286259 4241 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1954 st077032 68.9 µM -1.03879164707798 0.121442390910741 no 2916 0.149450823474965 4101 698907 SGTC_21 0849-0113 22.993 µM -1.03955026460071 0.121269993300324 no 2917 0.149274446949567 4094 1560156 SGTC_2359 9039622 200 µM -1.04345278366294 0.120385856765048 no 2918 0.148369318972186 4084 6463596 SGTC_1152 3909-8331 15.9 µM -1.0436582467349 0.120339434149208 no 2919 0.14832176697787 4094 16001939 SGTC_200 k038-0079 37.545 µM -1.04468808404196 0.120106941262808 no 2920 0.148083576951417 4102 3436683 SGTC_153 4077-0274 519.67 µM -1.04720728697597 0.119539548548358 no 2921 0.147501992584924 4124 3121976 SGTC_3000 9075062 71.4286 µM -1.04766408272967 0.119436868622682 no 2922 0.147396700623841 4097 17057871 SGTC_2310 7668677 200 µM -1.04916893604878 0.119099043400014 no 2923 0.147050186493633 4163 2197143 SGTC_3159 9100096 49.47 µM -1.05000418463999 0.118911829444045 no 2924 0.146858094404011 4077 25236875 SGTC_1335 1486-0900 202 µM -1.05109043865794 0.118668665765406 no 2925 0.146608527502799 4136 X1335 SGTC_2148 5546263 113.568 µM -1.05284357838404 0.118276957656187 no 2926 0.146206344274916 4122 792097 SGTC_1136 pergolide 1.05886 µM -1.05580639522759 0.117617048214649 no 2927 0.145528337927512 4112 47811 A dopamine receptor agonist. SGTC_2728 chlorpromazine 9.18 µM -1.05702977475832 0.117345326047027 no 2928 0.145248999428624 4193 2726 A thorazine and dopamine antagonist. SGTC_2039 Aminomethylbenzodioxan 200 µM -1.05811297898516 0.117105109249051 no 2929 0.145001968963817 4119 15053 SGTC_2459 5811157 9.22 µM -1.05954360921709 0.116788379765047 no 2930 0.14467613981952 4121 2870684 YBR192W RIM2 SGTC_17 0960-0276 49.807 µM -1.06095833898188 0.116475768183074 no 2931 0.144354417366729 4139 6821114 SGTC_1547 harmine 94.2 µM -1.06362897748403 0.115887258313891 no 2932 0.143748404960007 4121 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2118 5526350 200 µM -1.06383266517344 0.115842459900063 no 2933 0.143702255386317 4192 743594 SGTC_1674 st016616 23.6 µM -1.06486054701782 0.115616578491632 no 2934 0.143469520465802 4105 625830 SGTC_838 0109-0203 71.4 µM -1.06547724651352 0.115481206425118 no 2935 0.143330008420489 4168 759422 SGTC_2233 sulbentine 40.3845 µM -1.06787751823076 0.114955393735386 no 2936 0.142787882442424 4152 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_801 0866-0028 10.1 µM -1.06888465043903 0.114735275406906 no 2937 0.142560824650413 4183 6849771 SGTC_98 0074-0023 107.663 µM -1.07216946194429 0.114019433224007 no 2938 0.141821962038939 4182 3563821 SGTC_103 0844-0104 51.839 µM -1.07446066240569 0.113522010959695 no 2939 0.141308133274496 4068 5375804 SGTC_1694 st024011 44.9 µM -1.07525121401092 0.1133507408778 no 2940 0.141131135924062 4199 2787533 SGTC_3163 9099914 49.47 µM -1.07562860996353 0.113269044464949 no 2941 0.141046693420288 4182 16268368 SGTC_2358 9037157 4 µM -1.07568367101309 0.113257128691219 no 2942 0.14103437635205 4166 2388925 SGTC_2095 5432005 200 µM -1.07758121212558 0.112847027717992 no 2943 0.140610345185202 4175 783734 SGTC_2242 6630449 61.2675 µM -1.07803355133726 0.112749423794887 no 2944 0.140509391741329 4217 691249 YDR170C SEC7 SGTC_1477 0139-0234 16 µM -1.07945827710192 0.112442396204715 no 2945 0.140191741872348 4176 620880 SGTC_1225 1216-0074 20.6 µM -1.07946265378526 0.112441453953114 no 2946 0.140190766820638 4188 4241466 SGTC_2868 9035608 32.47 µM -1.08178659896754 0.11194193066232 no 2947 0.139673681318052 4147 6462614 SGTC_842 0271-0008 11.1 µM -1.08317410387089 0.111644449274754 no 2948 0.139365575895774 4217 1221709 SGTC_1893 st059353 36.1 µM -1.08596683552308 0.111047402711066 no 2949 0.138746832614768 4196 3112488 SGTC_1761 st044296 37 µM -1.09064781403113 0.110051810466581 no 2950 0.137713940868081 4170 1826700 SGTC_301 4119-0100 24.5 µM -1.09231354601174 0.109699077269081 no 2951 0.137347654158853 4214 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_781 4335-2806 94.4 µM -1.09270291135057 0.109616742942354 no 2952 0.137262130552939 4249 845254 SGTC_3038 9091290 49.47 µM -1.09441493714318 0.109255248235329 no 2953 0.136886517855436 4220 25236843 SGTC_1558 st069300 45.6 µM -1.09466259868182 0.109203025429619 no 2954 0.136832239965498 4127 24208000 SGTC_2225 6654152 15.4 µM -1.09606132753395 0.108908421097824 no 2955 0.136525968543632 4084 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_12 0849-0099 9.267 µM -1.09696714315289 0.108717940654428 no 2956 0.136327877743167 4097 6071388 SGTC_1432 4049-0298 68.4 µM -1.10119833518505 0.107831352953922 no 2957 0.13540517306486 4221 741646 SGTC_993 3909-8757 62.7 µM -1.10264398678212 0.107529633527169 no 2958 0.135090900140555 4133 4288324 YLR208W SEC13 SGTC_1730 st033808 45.1 µM -1.10443085082431 0.107157541593532 no 2959 0.134703142111319 4131 1045166 SGTC_1821 st053465 65.6 µM -1.10503219514861 0.10703252826936 no 2960 0.134572819462364 4199 675086 SGTC_3126 9127922 49.47 µM -1.10505421450778 0.107027952667496 no 2961 0.134568049095308 4243 45595682 SGTC_97 0535-0701 19.132 µM -1.10660085401662 0.106706915359539 no 2962 0.134233268955027 4095 2832013 YGL099W LSG1 SGTC_1126 isoteolin 1.0172 µM -1.10742688976947 0.106535739377464 no 2963 0.134054702706273 4146 133323 SGTC_817 1391-0715 46 µM -1.10776258444652 0.106466231433945 no 2964 0.133982181395192 4193 1353946 SGTC_3123 9126162 49.47 µM -1.10943508659208 0.106120416021636 no 2965 0.133621266609675 4268 25239884 SGTC_2244 6635614 200 µM -1.10954523673057 0.106097669309834 no 2966 0.13359752043175 4124 836499 SGTC_1995 st072814 61.1 µM -1.11063952506747 0.105871883038213 no 2967 0.133361771252128 4173 5769371 SGTC_1033 k072-0102 21.3 µM -1.11274719009424 0.105437984132299 no 2968 0.132908511012414 4166 5965931 SGTC_792 4534-1957 155 µM -1.11300899205935 0.10538417765567 no 2969 0.132852283791121 4158 1717904 SGTC_459 nigericin 15.3 µM -1.11326375339193 0.105331837266273 no 2970 0.132797584413489 4273 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2122 5258151 111.688 µM -1.1140587697412 0.105168623095912 no 2971 0.132626987515845 4206 2173356 SGTC_359 0081-0058 15.9 µM -1.11535902935841 0.104902078758057 no 2972 0.132348299551777 4313 3494159 SGTC_412 gemfibrozil 100 µM -1.11557107366301 0.104858657548636 no 2973 0.132302889859732 4124 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.11692821392198 0.104581058347233 no 2974 0.132012510017675 4190 140250 A respiratory chain inhibitor. SGTC_852 0418-0143 439 µM -1.11727161959502 0.1045109001612 no 2975 0.131939103125905 4209 5369229 SGTC_1367 1812-0510 76.9 µM -1.11778878182321 0.104405307657911 no 2976 0.131828606917453 4241 1142582 YDR527W RBA50 SGTC_3276 9139060 49.47 µM -1.11929125947955 0.104098975243855 no 2977 0.131507951719281 4298 4870619 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.11956968008088 0.104042281142901 no 2978 0.13144859103633 4214 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2011 4012611 177 µM -1.12017045757731 0.103920022584308 no 2979 0.131320565259026 4205 2049887 SGTC_1440 4100-1550 40 µM -1.12617459772263 0.102703896974375 no 2980 0.130045811727055 4213 742806 SGTC_716 1683-5115 658 µM -1.12849361392762 0.10223696499619 no 2981 0.129555756173359 4184 723597 SGTC_798 1287-0182 476 µM -1.13058868769833 0.101816452999512 no 2982 0.129114125498279 4267 1649755 SGTC_429 1112-0049 25.5 µM -1.13269697252185 0.101394561722504 no 2983 0.128670764741802 4202 2836170 SGTC_1964 st076914 61 µM -1.1339616855495 0.101142090432919 no 2984 0.128405310010776 4264 24208661 SGTC_2232 chlorophetanol 41.5365 µM -1.13479637473737 0.100975714809295 no 2985 0.128230322779245 4285 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1841 st054148 70 µM -1.13703447527028 0.100530587078612 no 2986 0.12776193693501 4258 675442 SGTC_56 0957-0365 83.25 µM -1.13760291095875 0.100417761269834 no 2987 0.127643165284339 4195 6752360 SGTC_2597 laccaic acid a 100 µM -1.13790878519774 0.100357088151759 no 2988 0.127579286242949 4231 5491415 A textile dye. SGTC_2294 7971431 200 µM -1.1434596664922 0.0992606613763317 no 2989 0.12642389582756 4229 5741572 SGTC_181 1447-1644 8.07 µM -1.14367120822109 0.0992190509593843 no 2990 0.126380009062677 4217 534600 SGTC_2903 5923464 63.88 µM -1.14616372957835 0.098729730367727 no 2991 0.125863706160811 4237 2876576 SGTC_1820 st053765 18.6 µM -1.14846969163198 0.0982786091788344 no 2992 0.125387358977598 4282 3690829 SGTC_2817 7995342 71.43 µM -1.14883594270838 0.0982070977158087 no 2993 0.125311817723366 4243 18879975 SGTC_376 3970-0862 59.1 µM -1.14928979727033 0.0981185343395197 no 2994 0.125218251867559 4275 3135186 SGTC_1602 st001878 87.6 µM -1.15290608164824 0.097414956753703 no 2995 0.124474467790622 4228 595405 YLR310C CDC25 SGTC_2887 9044784 58.44 µM -1.15317811017986 0.0973621814365218 no 2996 0.124418643148513 4205 6465546 SGTC_1665 st014639 11.4 µM -1.16336161827213 0.0954015764383293 no 2997 0.122341407568518 4303 981133 YIL048W NEO1 SGTC_2427 5545055 42.75 µM -1.16356323872228 0.0953630545365433 no 2998 0.122300528178422 4192 5372858 SGTC_395 anisomycin 6.25 µM -1.16582156779272 0.0949323570357793 no 2999 0.121843297598499 4279 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3066 9117245 49.47 µM -1.16731410742087 0.0946484947635206 no 3000 0.121541771782756 4308 17176980 SGTC_1272 0839-0021 27 µM -1.16749060948729 0.0946149677004875 no 3001 0.121506149195216 4270 5027250 SGTC_1607 st000305 50.6 µM -1.17125648262212 0.0939017141711111 no 3002 0.120747848911028 4273 5457690 SGTC_210 3551-0445 56.827 µM -1.17320992743072 0.0935333000209395 no 3003 0.120355815979869 4302 2865180 YOR207C RET1 SGTC_1826 st055655 41.6 µM -1.17321927797741 0.0935315391051361 no 3004 0.120353941595957 4284 676168 SGTC_1776 st049249 45.9 µM -1.17564490184457 0.0930755667580266 no 3005 0.119868402297883 4286 1822314 SGTC_1675 st018485 24.5 µM -1.17855305833001 0.0925310554781245 no 3006 0.119288096473811 4294 3323024 SGTC_1130 3454-2858 15.9 µM -1.17906186816098 0.092436030738969 no 3007 0.119186770550279 4268 715628 YIL048W NEO1 SGTC_29 0299-0004 12.984 µM -1.18047289066391 0.0921728876010837 no 3008 0.11890609317909 4166 16871 A napthoquinone isolated from Swertia calycina. SGTC_2187 6125751 200 µM -1.18404271400603 0.0915096241924999 no 3009 0.118198077448394 4273 874498 SGTC_3223 9129970 49.47 µM -1.18423521422885 0.0914739589531483 no 3010 0.118159983088555 4273 17248386 SGTC_1500 4488-1866 171 µM -1.18560849746493 0.0912198244730532 no 3011 0.117888472464181 4334 2900003 SGTC_545 4218-0007 221 µM -1.18570639228885 0.0912017284458971 no 3012 0.117869134632737 4260 2840508 SGTC_908 3448-7491 47.7 µM -1.1937152025822 0.0897302878298707 no 3013 0.116294695805526 4275 1203031 SGTC_3178 9107506 49.47 µM -1.19479124446352 0.0895339417142825 no 3014 0.116084301004725 4269 8897194 SGTC_2645 abamectin 100 µM -1.1958250043162 0.0893456119289583 no 3015 0.115882428061196 4238 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_113 0099-0221 2.5 µM -1.19812744287915 0.0889272143622171 no 3016 0.115433703339618 4252 89219 SGTC_2052 5265182 7.135 µM -1.19988535498472 0.088608751046005 no 3017 0.115091934216339 4296 1239884 SGTC_23 0213-0011 39.996 µM -1.20067946475128 0.0884651690070668 no 3018 0.114937781427886 4288 627608 SGTC_2611 pyromycin 23.93 µM -1.20159001722811 0.0883007465196983 no 3019 0.114761205550928 4256 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1189 1431-2119 7.28 µM -1.20449969221798 0.0877768603731856 no 3020 0.114198250475518 4274 3107275 SGTC_1202 1988-0068 29.6 µM -1.20464117499998 0.0877514456770227 no 3021 0.114170927046767 4269 2850480 SGTC_158 k038-0087 26.446 µM -1.21014018200321 0.0867679013348493 no 3022 0.11311255338411 4198 X158 SGTC_1199 1638-0010 4.46 µM -1.21186001963689 0.0864619910760315 no 3023 0.112782984275909 4265 3111136 SGTC_341 1486-1430 230 µM -1.21293685011607 0.0862708644517843 no 3024 0.112576982709872 4250 2054753 YPL210C SRP72 SGTC_2712 st079126 47.7 µM -1.21352399156629 0.0861667859297298 no 3025 0.112464773709313 4274 3152970 SGTC_2734 clemastine 41.6 µM -1.21440971104896 0.086009958292093 no 3026 0.112295654471769 4344 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1539 benzyladenosine 56 µM -1.22012530855809 0.0850030730818761 no 3027 0.111208687883482 4292 92208 A nucleotide analog. SGTC_1512 0259-0544 12.2 µM -1.22119236651274 0.0848160780605017 no 3028 0.111006596890444 4270 18476 SGTC_1237 0330-0133 46.1 µM -1.22445083243218 0.0842469620018686 no 3029 0.110391101694423 4237 X1237 YHR072W ERG7 SGTC_118 0083-0097 135.343 µM -1.22775286690651 0.0836731650993783 no 3030 0.109769876972552 4287 5207356 SGTC_1372 2752-0194 270 µM -1.22830344606345 0.0835777768365185 no 3031 0.109666538924562 4247 823334 SGTC_1235 benzylparaben 21.5 µM -1.22834334064781 0.0835708682452256 no 3032 0.109659053835836 4334 7180 SGTC_1070 indatraline 8.81 µM -1.2283859175285 0.0835634956309423 no 3033 0.109651065894792 4348 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3094 9117742 49.47 µM -1.23048392376504 0.083200809888061 no 3034 0.109257971721397 4254 17149698 SGTC_1046 2001-0062 216 µM -1.23054462810649 0.0831903334767383 no 3035 0.109246612907541 4232 739778 SGTC_640 3381-0960 37.1 µM -1.23068848574105 0.0831655103538602 no 3036 0.109219698087284 4361 1745025 SGTC_1084 voriconazole 435 nM -1.2308675510153 0.0831346198149314 no 3037 0.10918620280498 4320 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1419 3993-2473 62.6 µM -1.23890891137105 0.0817562824635921 no 3038 0.10768961656154 4388 704026 SGTC_1093 fluphenazine 7.97 µM -1.24055455035545 0.0814763455766776 no 3039 0.107385175298151 4342 6602611 An atypical antipsychotic. SGTC_157 1348-1695 65.819 µM -1.24139055301234 0.0813344117485143 no 3040 0.107230753649893 4251 5380510 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.24240857235866 0.0811618276572466 no 3041 0.107042927194012 4299 2724 A muscle relaxant with antifungal properties. SGTC_1766 st045414 44.774 µM -1.24459593601062 0.0807919403972648 no 3042 0.106640157494495 4328 253960 SGTC_3222 9128301 49.47 µM -1.2449639409577 0.0807298353587129 no 3043 0.106572502626978 4312 4911358 SGTC_1214 0358-0031 63.7 µM -1.24553807284395 0.0806330160487784 no 3044 0.106467014798522 4382 4301366 SGTC_889 0919-1524 82.7 µM -1.24615791080625 0.0805285875242102 no 3045 0.10635321383835 4337 3905452 SGTC_2290 7904846 200 µM -1.24837282571279 0.0801562597359605 no 3046 0.10594727788541 4352 2962154 SGTC_2874 9043904 71.43 µM -1.24850008694198 0.080134906685793 no 3047 0.105923988293281 4259 4463428 SGTC_2654 protoveratrine a 100 µM -1.25119007976177 0.0796845605727475 no 3048 0.105432568335467 4332 5702278 A heart drug and vasodilator. SGTC_896 0964-0007 44.5 µM -1.25142782696135 0.0796448503130483 no 3049 0.10538921505639 4299 6756758 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.26106984829962 0.078046956622024 no 3050 0.103641841379862 4331 3256 An antibiotic and ribosome inhibitor. SGTC_885 0865-0106 16.8 µM -1.26867476587154 0.0768039051707878 no 3051 0.102278543027303 4296 2793380 SGTC_721 1187-1332 279 µM -1.27669600627586 0.0755091762539069 no 3052 0.100854795988361 4309 25730 SGTC_2124 5246320 200 µM -1.27860374345355 0.0752037058202449 no 3053 0.100518315536014 4365 579342 SGTC_1204 4049-0315 18.3 µM -1.27897419831235 0.0751444972939471 no 3054 0.100453070990235 4391 588402 SGTC_1720 st037298 9.481 µM -1.28137074379221 0.0747623241010398 no 3055 0.100031737592921 4340 597396 SGTC_3170 9103054 49.47 µM -1.28194502153921 0.07467096561624 no 3056 0.0999309665370161 4324 16432970 SGTC_1591 genipin 88.4 µM -1.28659035862515 0.0739350953058529 no 3057 0.099118552978527 4384 442424 A DNA cross-linking agent. SGTC_377 3970-0964 33.1 µM -1.28700235984089 0.0738700984493889 no 3058 0.0990467328099126 4326 16481235 SGTC_950 1165-0508 94.1 µM -1.28772337082239 0.0737564576403675 no 3059 0.0989211375799118 4346 6148369 SGTC_3315 9136395 68.55 µM -1.29043504769869 0.073330257817106 no 3060 0.0984498249829367 4345 16876844 SGTC_1664 st014217 9.02 µM -1.2907405881245 0.0732823537342078 no 3061 0.0983968226935772 4410 3982782 SGTC_612 0302-0167 22.4 µM -1.29257765299592 0.0729948344944798 no 3062 0.0980785863526194 4365 235821 SGTC_1891 st059073 26.2 µM -1.29383848622269 0.0727980015191681 no 3063 0.0978606079411003 4432 688754 SGTC_2636 apigenin dimethyl ether 100 µM -1.29551175339674 0.0725374099097014 no 3064 0.0975718747352557 4344 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2319 6033012 152.6 µM -1.30552938045815 0.0709922033374325 no 3065 0.0958563247291641 4318 847246 SGTC_2706 st078239 82.5 µM -1.3056295120582 0.0709768867886939 no 3066 0.0958392895947212 4361 15434492 SGTC_1426 4048-4480 71.7 µM -1.30688613621773 0.0707848840344886 no 3067 0.0956256926234385 4390 14224343 SGTC_2643 anethole 100 µM -1.30889703014218 0.0704784651149387 no 3068 0.0952846163832482 4361 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3293 9120939 62.045 µM -1.31119018288725 0.0701302813471247 no 3069 0.0948967591204668 4357 934087 SGTC_3050 9093513 49.47 µM -1.3120311954592 0.0700029172749973 no 3070 0.0947548045902297 4340 25236664 SGTC_1269 0831-0796 3.05 µM -1.31224851232704 0.0699700354690428 no 3071 0.0947181491271133 4399 927758 SGTC_1017 4239-0030 168 µM -1.31283317213569 0.0698816306897081 no 3072 0.0946195847509083 4388 1149593 SGTC_2733 amorolfine 100 µM -1.32078886976337 0.0686871981181518 no 3073 0.0932858859644669 4533 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2826 7992541 19.48 µM -1.32217886447703 0.0684801358419196 no 3074 0.0930542986561125 4391 2985066 SGTC_2413 inermin 26.06 µM -1.32283784815664 0.0683821379430399 no 3075 0.0929446538536162 4435 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.32559853701488 0.0679727698856736 no 3076 0.0924863555412207 4479 688664 SGTC_1429 4049-0205 9.46 µM -1.33022445769504 0.0672910616338314 no 3077 0.0917221640726112 4438 22774478 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.33134252355528 0.067127091361161 no 3078 0.0915381661038037 4382 5379071 SGTC_827 3253-0474 693 µM -1.33167023454086 0.0670790894104176 no 3079 0.0914842872041088 4411 5402065 SGTC_3108 9121785 49.47 µM -1.33520960439819 0.0665623451494824 no 3080 0.0909038771477975 4242 17140271 SGTC_2957 9076800 11.52 µM -1.33567132504464 0.0664951622416676 no 3081 0.0908283629338171 4361 16459615 SGTC_3118 9124250 49.47 µM -1.33567343053379 0.0664948560016304 no 3082 0.0908280186886104 4351 1504786 SGTC_1073 triclabendazole 3.09 µM -1.33711240294508 0.0662858150116098 no 3083 0.090592974612327 4420 50248 An antihelmetic and likely tubulin inhibitor. SGTC_460 trequinsin 123 µM -1.3407987596552 0.065752616112717 no 3084 0.0899928995212334 4480 5537 A vasodilator. SGTC_2370 9071495 200 µM -1.34233942832466 0.0655307595943724 no 3085 0.0897429823542134 4397 21791103 SGTC_476 mead acid 10 µM -1.3460468861906 0.0649992644411844 no 3086 0.0891436981103092 4459 5312531 An omega 9 fatty acid. SGTC_2266 7929956 200 µM -1.353572014336 0.0639307684309768 no 3087 0.0879364801934659 4342 2967153 SGTC_2534 helenine 20.12 µM -1.35569585540319 0.0636316883830192 no 3088 0.0875979793353423 4419 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2295 7971645 200 µM -1.35886640589916 0.0631872373941773 no 3089 0.0870944629293258 4468 2978226 YKL099C UTP11 SGTC_2677 mitomycin C 100 µM -1.36018577232496 0.0630030010692541 no 3090 0.086885571872944 4478 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2137 5261020 140 µM -1.36347861751457 0.0625450135069079 no 3091 0.086365859432933 4386 763655 SGTC_332 4112-0506 40.9 µM -1.36370725393868 0.0625133100714755 no 3092 0.0863298600536669 4385 2790355 SGTC_667 1498-1044 59 µM -1.36621071611658 0.0621669913464797 no 3093 0.0859364174875311 4415 6739982 SGTC_99 0109-0120 622.8 µM -1.36624111212658 0.0621627957018215 no 3094 0.0859316487281066 4415 759414 SGTC_2507 purpurin 79.67 µM -1.36887794674232 0.0617996662214318 no 3095 0.0855187151908828 4406 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_921 1561-0023 372 µM -1.37692333621583 0.0607019304823912 no 3096 0.0842679757129969 4405 24050882 SGTC_958 1222-0007 33 µM -1.37815713103511 0.0605349451067733 no 3097 0.0840773898354279 4478 7312461 SGTC_2818 7996756 12.99 µM -1.37863265810806 0.0604706819236075 no 3098 0.0840040210155027 4433 2241621 SGTC_3026 9090633 49.47 µM -1.38058492450879 0.0602074100556307 no 3099 0.0837033106275917 4418 25236842 SGTC_2652 actinonin 100 µM -1.3852950348787 0.0595759244307853 no 3100 0.0829811356675727 4478 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.38566737342678 0.0595262271325803 no 3101 0.0829242475832701 4496 4620898 SGTC_2872 9044037 25.97 µM -1.38787021245009 0.0592328711482573 no 3102 0.0825882849029026 4478 6465195 SGTC_2120 5538279 151.968 µM -1.39048558702825 0.0588860504840048 no 3103 0.0821907364894204 4398 2058197 SGTC_1647 st011722 22.4 µM -1.39088343626275 0.0588334322462738 no 3104 0.0821303881824747 4402 2854783 SGTC_760 0568-0725 82.9 µM -1.39095711585438 0.0588236916751191 no 3105 0.0821192156566938 4442 3916171 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.39233702319598 0.0586414992094262 no 3106 0.0819101826031935 4450 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1750 st081859 2.357 µM -1.39335914288601 0.0585068321141565 no 3107 0.0817556071273352 4351 5291695 SGTC_1021 4476-0760 85.3 µM -1.39589961959851 0.0581731690812304 no 3108 0.0813723626184454 4454 746768 SGTC_1441 4106-0040 13 µM -1.3968439724079 0.0580495208048046 no 3109 0.0812302479521539 4463 2904180 SGTC_438 sphingosine 6.67 µM -1.39892425228956 0.0577778692273403 no 3110 0.0809178495306389 4355 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1960 st011366 51.8 µM -1.39915827953949 0.0577473716261066 no 3111 0.0808827621760166 4452 3972846 SGTC_37 0566-0070 1.56 µM -1.39922663548438 0.0577384661106431 no 3112 0.0808725158394149 4352 1626686 SGTC_1963 st076565 50.3 µM -1.39964299022249 0.0576842461062055 no 3113 0.0808101267626182 4450 4914280 SGTC_1121 fusaric acid 630.51 nM -1.40213510711189 0.0573605455427345 no 3114 0.080437452615655 4417 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2424 5537928 59.2 µM -1.41154939148976 0.0561506072802873 no 3115 0.0790413413894085 4454 5382802 SGTC_307 1501-1223 22.3 µM -1.41704920359578 0.0554531306782684 no 3116 0.0782342711646515 4472 2830329 SGTC_808 0711-0032 135 µM -1.4173203831536 0.0554189179115866 no 3117 0.0781946391882609 4414 4252555 SGTC_932 2857-0803 154 µM -1.42280883732989 0.0547300551177713 no 3118 0.0773957894081959 4458 674898 SGTC_800 3448-7362 155 µM -1.42958057640801 0.0538894740793191 no 3119 0.0764187167826457 4530 15991913 SGTC_2317 5986382 200 µM -1.43160426712554 0.0536402655348235 no 3120 0.0761285538743614 4474 877883 SGTC_1932 st074806 40.9 µM -1.43857529709866 0.0527887964242432 no 3121 0.0751354447656818 4496 17251235 SGTC_3196 9111891 49.47 µM -1.44184467132866 0.0523931732846468 no 3122 0.0746730988137805 4440 18891510 SGTC_770 0389-1121 67.2 µM -1.45246669622973 0.0511240423244117 no 3123 0.073185941446234 4506 6753108 SGTC_1431 4049-0260 9.09 µM -1.45676147949119 0.0506178940445357 no 3124 0.0725911162216067 4500 3854841 SGTC_1927 st060202 13.8 µM -1.4581764376276 0.0504520154324711 no 3125 0.0723959583357407 4397 688887 SGTC_1443 4112-3303 14 µM -1.45927870398342 0.050323094712754 no 3126 0.0722442071682104 4519 704433 SGTC_1579 chlormadinone acetate 49.4 µM -1.45936260932108 0.0503132919342191 no 3127 0.0722326657481566 4495 45114258 A steroidal progestin. SGTC_627 1391-0720 175 µM -1.45991513567901 0.0502487775048761 no 3128 0.0721566994496662 4442 997839 SGTC_2323 6148992 148.28 µM -1.46096150928553 0.0501267808582412 no 3129 0.0720130024047159 4426 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_573 3702-0553 84.7 µM -1.46188874552739 0.0500188718729928 no 3130 0.0718858497736001 4420 1222756 SGTC_2939 9044578 71.43 µM -1.46379134639517 0.0497980328830257 no 3131 0.0716254837964838 4409 2653634 SGTC_2592 piperlongumine 83.33 µM -1.46558751608134 0.0495902620098601 no 3132 0.0713803471538245 4459 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1782 st039423 80.636 µM -1.46755017588581 0.0493640240518137 no 3133 0.0711132251661133 4488 2068169 SGTC_3311 9131146 2.8755 µM -1.47315947040995 0.0487219750178683 no 3134 0.0703540203625095 4419 4900406 YPR165W RHO1 SGTC_531 3788-1495 174 µM -1.47380809409924 0.0486481650075573 no 3135 0.0702666341974187 4466 2896655 SGTC_3079 9117512 49.47 µM -1.47572232081452 0.0484308570078155 no 3136 0.0700092256622832 4565 7185044 SGTC_294 k038-0071 157 µM -1.47903117726625 0.048057058353565 no 3137 0.0695659911944382 4504 24152826 SGTC_2938 9059746 27.26 µM -1.48436143887624 0.0474597623983692 no 3138 0.0688565294998841 4481 6471769 SGTC_723 4182-0001 115 µM -1.48971810714099 0.0468655142301719 no 3139 0.0681491857618701 4494 744821 YLR208W SEC13 SGTC_2158 5657123 3.6195 µM -1.49882158875168 0.0458693116386547 no 3140 0.0669599611958443 4486 2858827 SGTC_2864 9034755 47.6 µM -1.50127378956269 0.0456038943957691 no 3141 0.0666423806621257 4437 4930451 SGTC_524 r073-0010 27.8 µM -1.50484696084245 0.0452193593154089 no 3142 0.0661817135489057 4427 2772106 SGTC_2727 riluzole 51.77 µM -1.50597093357823 0.0450989411923381 no 3143 0.0660373177318888 4541 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2526 patulin 37.61 µM -1.50653128660919 0.0450390035893594 no 3144 0.0659654208944934 4511 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_720 r052-1644 49.9 µM -1.51078290595904 0.0445863193333616 no 3145 0.0654218856652689 4506 1422863 YOR257W CDC31 SGTC_840 0245-0196 390 µM -1.5140940014148 0.0442363203706008 no 3146 0.065000999930141 4558 3827528 SGTC_674 0498-0004 451 µM -1.51419349645926 0.0442258376300201 no 3147 0.0649883853454523 4487 4231473 SGTC_1775 st081588 35.1725 µM -1.51449525799101 0.0441940564543988 no 3148 0.0649501378109484 4486 1426443 YGL099W LSG1 SGTC_167 3672-0051 66.205 µM -1.51580398964581 0.0440564353551487 no 3149 0.0647844614731588 4418 3237971 SGTC_2755 lomerizine 42.69 µM -1.51608817326444 0.0440265974296241 no 3150 0.0647485292029281 4443 3949 A calcium channel blocker. SGTC_779 1360-0071 233 µM -1.51912289245804 0.0437089814646576 no 3151 0.0643657827119132 4531 7566 SGTC_3192 9110362 49.47 µM -1.51912675423119 0.0437085784695834 no 3152 0.0643652967777862 4508 16649480 SGTC_2679 rapamycin 1 nM -1.5204675302499 0.0435688429885424 no 3153 0.0641967566730321 4373 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2893 9048488 25.97 µM -1.52216782054897 0.0433921577444725 no 3154 0.0639835179784724 4537 6467338 SGTC_1195 1502-0147 41.1 µM -1.52282854229522 0.0433236552712182 no 3155 0.0639008035605405 4512 817940 SGTC_2145 5634607 200 µM -1.52560043228147 0.0430372216020226 no 3156 0.0635547022072285 4515 308662 SGTC_3158 9100007 49.47 µM -1.52625817952451 0.0429694782757809 no 3157 0.0634727896669713 4522 19297233 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.5292638870528 0.0426610072838194 no 3158 0.063099519169483 4507 688751 SGTC_1391 3442-0225 151 µM -1.53639928009497 0.0419358803168703 no 3159 0.0622202416120215 4494 5227075 SGTC_3301 9125354 19.7965 µM -1.53841850583459 0.0417324999351877 no 3160 0.0619731601554193 4484 41905162 SGTC_2140 5586273 200 µM -1.53842546633341 0.0417318002441866 no 3161 0.0619723097639605 4489 854421 SGTC_403 arphamenine a 50 µM -1.53848701228847 0.0417256138666809 no 3162 0.0619647908493092 4516 5487158 An arginine aminopeptidase inhibitor. SGTC_655 k060-0012 42 µM -1.53859142199694 0.0417151206780834 no 3163 0.0619520370058975 4499 5994525 SGTC_2326 6164455 177.58 µM -1.54000547344592 0.0415732187090083 no 3164 0.0617795096245152 4450 2888790 SGTC_2391 6285546 200 µM -1.54030066184707 0.0415436455506441 no 3165 0.0617435412690759 4527 846083 SGTC_957 1187-1561 14.1 µM -1.54374906063149 0.0411994321346373 no 3166 0.0613245680108751 4458 1538454 SGTC_1879 gemcitabine 100 µM -1.54401548516032 0.0411729345913524 no 3167 0.061292290644789 4478 60750 A nucleoside analog which inhibits DNA replication. SGTC_3112 9123419 49.47 µM -1.54527248771043 0.0410481043511179 no 3168 0.0611401836368224 4558 17015854 SGTC_2862 9027634 71.43 µM -1.54730182341378 0.0408472232498504 no 3169 0.0608952411340345 4480 5012562 SGTC_282 k297-0036 65.7 µM -1.54730875829128 0.0408465381459278 no 3170 0.060894405405949 4526 5061378 SGTC_2351 9026858 72.31 µM -1.54916538088895 0.0406634554976362 no 3171 0.060670984611487 4409 1409300 SGTC_832 4083-0019 164 µM -1.55451842188841 0.0401393146984953 no 3172 0.0600304029599091 4590 1990758 SGTC_2121 5257820 149.641 µM -1.55566509794482 0.0400277552407642 no 3173 0.0598938750579055 4547 791256 SGTC_2937 9044753 11.33 µM -1.55610557723102 0.0399849682989365 no 3174 0.0598414945095768 4459 6465530 YGL099W LSG1 SGTC_1076 itraconazole 331 nM -1.55629916947528 0.0399661750438506 no 3175 0.0598184844229451 4533 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_748 act1.228 77.9 µM -1.56166651276536 0.0394479843534746 no 3176 0.0591832857837509 4516 4421505 YNR035C ARC35 SGTC_2801 7907800 81.82 µM -1.56444170374804 0.0391822045865021 no 3177 0.0588569366718946 4509 6620925 SGTC_700 3453-2283 142 µM -1.56477382748318 0.0391504950091543 no 3178 0.0588179753137152 4558 565664 SGTC_1074 carmofur 3.8 µM -1.5715176111818 0.0385111368158529 no 3179 0.0580312334776253 4569 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1436 4092-1007 8.32 µM -1.57200960366378 0.038464827471604 no 3180 0.0579741619986873 4541 2881121 SGTC_1908 st060353 56.5 µM -1.58052060270976 0.0376708797159496 no 3181 0.0569938462412203 4539 4227716 SGTC_646 4092-0839 27.3 µM -1.58318005515343 0.0374255540279744 no 3182 0.0566902155260481 4555 877796 SGTC_543 3844-1095 191 µM -1.5840465109535 0.0373459087351507 no 3183 0.0565915676110447 4549 4230703 SGTC_3091 9116372 49.47 µM -1.58442749869133 0.0373109318964855 no 3184 0.0565482341450749 4575 17169793 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.58525974539556 0.0372346199961328 no 3185 0.0564536655189203 4616 688801 SGTC_1628 st004252 77.7 µM -1.58564631216429 0.0371992176016334 no 3186 0.0564097821491184 4528 692968 SGTC_1336 1486-0901 104 µM -1.58658216273652 0.0371136248136875 no 3187 0.0563036549725747 4547 5006114 SGTC_2992 9074591 71.4286 µM -1.58916085415825 0.0368786104695723 no 3188 0.0560120408958657 4477 17741321 SGTC_293 4049-0273 38.5 µM -1.59625538193821 0.0362383090975823 no 3189 0.0552158936543193 4438 1380311 SGTC_347 4534-1311 26.2 µM -1.59855841232006 0.0360324213971232 no 3190 0.0549593783049932 4565 2862016 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.60164787987066 0.0357577329357156 no 3191 0.0546167483249148 4536 688669 SGTC_2336 9001819 198.65 µM -1.60974332152499 0.0350460885404739 no 3192 0.0537269516166458 4554 2989602 SGTC_1144 3486-0183 12.5 µM -1.61347891853397 0.0347216453784755 no 3193 0.0533202498645488 4557 6744069 SGTC_1319 1306-0155 43.7 µM -1.62089708548252 0.0340846760029773 no 3194 0.0525198560159958 4584 3122360 SGTC_392 N-ethylmaleimide 8.33 µM -1.62138118362843 0.0340434445338957 no 3195 0.0524679568301603 4527 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.62241349455008 0.0339556578186466 no 3196 0.0523574208333104 4599 91467 include heat shock SGTC_1785 bathophenanthroline 24 µM -1.62320273824246 0.0338886669617757 no 3197 0.052273036348676 4490 72812 An iron chelator. SGTC_1783 st039459 87.517 µM -1.62320842291502 0.0338881848424615 no 3198 0.0522724289459159 4605 729761 SGTC_1992 st073643 23.3 µM -1.62451207336056 0.0337777706478562 no 3199 0.0521332828858494 4567 3161292 SGTC_2806 7952793 58.44 µM -1.62736390126455 0.033537263551138 no 3200 0.0518299167964661 4573 2972490 SGTC_2892 9047358 58.44 µM -1.63018015018136 0.0333011421306466 no 3201 0.0515317139450842 4563 6466771 SGTC_379 3970-0972 5.9 µM -1.63095402567028 0.0332364987903194 no 3202 0.0514500103513624 4567 2898042 YBL034C STU1 SGTC_3156 9099931 49.47 µM -1.63175838251355 0.0331694188625553 no 3203 0.0513651978473514 4599 18111053 SGTC_1175 0741-0056 27.6 µM -1.63463059745329 0.032930797960295 no 3204 0.0510632547180813 4620 765927 SGTC_802 4112-3352 742 µM -1.6470528113584 0.0319150090269523 no 3205 0.0497735956278213 4590 704594 SGTC_6 0844-0013 19.835 µM -1.65360582593464 0.031389669524298 no 3206 0.0491038140981337 4658 1584900 SGTC_305 1682-2595 20.8 µM -1.66094848849208 0.0308095409724812 no 3207 0.0483618963358558 4583 226033 SGTC_974 1326-0144 138 µM -1.66203317512972 0.0307245993262307 no 3208 0.0482530614340072 4581 5411856 SGTC_678 1218-2179 85.9 µM -1.66793700739375 0.0302656643390414 no 3209 0.047664116128882 4622 6820081 YOR116C RPO31 SGTC_963 1269-2853 151 µM -1.67191036818932 0.0299600046129383 no 3210 0.0472709989842355 4572 3668223 SGTC_300 r073-0011 5.04 µM -1.67867516826615 0.0294454985930529 no 3211 0.0466076839981346 4582 2735780 SGTC_2154 5570129 200 µM -1.68936300163768 0.0286475849870985 no 3212 0.0455749433498354 4634 673366 SGTC_1057 3448-5381 134 µM -1.69559924079729 0.0281903752463285 no 3213 0.0449809008317078 4573 5497911 SGTC_1641 st009299 47.1 µM -1.69681608431378 0.0281018744321509 no 3214 0.0448657184420855 4527 4046054 SGTC_1525 8-methoxypsoralen 92.5 µM -1.70228899224083 0.027706686045741 no 3215 0.0443506036483067 4602 4114 Related to psoralen; DNA damaging agent. SGTC_2502 avocadyne acetate 18.59 µM -1.70508801146453 0.027506370831825 no 3216 0.0440890055919463 4548 3952079 SGTC_850 0388-0143 75.9 µM -1.70659040841935 0.0273993488910012 no 3217 0.0439491045928845 4590 67273 SGTC_1703 st026983 48.3 µM -1.72004955893629 0.0264559998901199 no 3218 0.0427117167212976 4624 1104023 SGTC_2832 7992762 51.95 µM -1.72825687026327 0.0258941861468294 no 3219 0.0419710909164694 4517 2985177 SGTC_165 k038-0023 64.381 µM -1.72840957682794 0.0258838282832987 no 3220 0.0419574098645371 4558 46368543 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.73273378286623 0.0255919595423203 no 3221 0.0415714985148598 4593 5377381 SGTC_356 1634-0012 32.5 µM -1.73624025858685 0.0253573125288218 no 3222 0.0412606807960958 4606 735457 SGTC_1344 1488-0097 29.1 µM -1.73705089706066 0.0253033233129046 no 3223 0.0411890937049152 4633 747966 SGTC_582 0987-0078 156 µM -1.73742778729622 0.0252782549163385 no 3224 0.041155845020315 4638 1625765 SGTC_2135 5326629 150.42 µM -1.74785714361027 0.024592770288761 no 3225 0.0402443837092814 4561 5020077 SGTC_2812 7970281 58.44 µM -1.74791444291589 0.024589047729228 no 3226 0.0402394217652823 4617 2233435 SGTC_1249 0481-0015 10.2 µM -1.75164600080281 0.0243476359761135 no 3227 0.0399173487291618 4554 4227577 SGTC_2925 9010536 32.5 µM -1.75536135786292 0.0241092525595818 no 3228 0.0395987586847625 4535 2994177 SGTC_268 camptothecin 39.6153 µM -1.76413720918165 0.0235539553731798 no 3229 0.0388544405941102 4560 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2929 9013348 24.6 µM -1.77029589689576 0.0231707179602311 no 3230 0.038338930620981 4581 2995952 SGTC_744 1594-0068 283 µM -1.7750904918601 0.022876010634968 no 3231 0.0379414733430005 4612 668392 SGTC_2417 cerulenin 830 nM -1.7787836470199 0.0226511637988824 no 3232 0.0376376196091159 4608 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1597 7-benzyloxygramine 47.5 µM -1.80020124257981 0.0213836347518583 no 3233 0.035914433856785 4522 260807 SGTC_2797 7859098 81.82 µM -1.82259100410946 0.0201232116200883 no 3234 0.0341826795677342 4593 972681 SGTC_1446 4239-0190 62 µM -1.82741420275204 0.0198601006374073 no 3235 0.0338187577419094 4647 1340085 SGTC_1655 st012546 55.1 µM -1.83410707633216 0.0194998373645277 no 3236 0.0333190506098363 4641 720985 YLR208W SEC13 SGTC_344 k064-0035 6.43 µM -1.84019787663928 0.0191768217848808 no 3237 0.032869595809879 4580 5088750 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.841910851191 0.0190868006943509 no 3238 0.0327440955517054 4614 1377 SGTC_2715 st079500 56.4 µM -1.84426958851946 0.0189634313699459 no 3239 0.0325719306122349 4647 28246688 SGTC_2567 aureobasidin a 60 nM -1.84638618094218 0.0188533049859206 no 3240 0.0324180761444214 4665 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1690 st023502 41.2 µM -1.84658429351273 0.0188430250850401 no 3241 0.032403706139934 4649 24207482 SGTC_710 3448-4187 58 µM -1.85152682874034 0.0185881002581249 no 3242 0.0320468993689696 4613 3946412 SGTC_1887 st057648 70.8 µM -1.85186908892874 0.0185705564723196 no 3243 0.0320223118231837 4639 688672 SGTC_1030 k029-0042 36.7 µM -1.85196159442916 0.0185658171885219 no 3244 0.0320156690178913 4630 6080581 SGTC_1145 3546-0597 10.2 µM -1.85261704218515 0.0185322664798667 no 3245 0.0319686340063892 4639 875334 SGTC_2984 9022109 38.96 µM -1.86846774079378 0.0177364899045169 no 3246 0.0308484512849652 4643 6459207 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.86884774034053 0.0177177757545918 no 3247 0.0308220003722199 4536 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1212 0520-0165 585 µM -1.86967029211512 0.0176773245714777 no 3248 0.0307648086980844 4658 5403258 SGTC_733 4069-0007 56.1 µM -1.87329516842756 0.0174999992086266 no 3249 0.0305138183516414 4651 5717425 YNL287W SEC21 SGTC_1719 st032227 49.2 µM -1.87517796925313 0.0174084952327265 no 3250 0.0303841219654692 4640 3125804 SGTC_2582 agaric acid 100 µM -1.87933567979051 0.0172078772238539 no 3251 0.0300993363865642 4304 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2498 4'-Methoxychalcone 54.63 µM -1.89198406306095 0.0166096690641321 no 3252 0.0292465521161292 4651 641818 YHR062C RPP1 SGTC_2571 chrysanthemic acid 100 µM -1.90115137451099 0.0161873029515439 no 3253 0.0286410940310436 4635 2743 An insecticide. SGTC_929 2805-0021 398 µM -1.90292997069597 0.0161064322592617 no 3254 0.0285248418130588 4673 3098024 SGTC_2189 6047310 154.431 µM -1.90848435495212 0.015856106054038 no 3255 0.0281643216790109 4687 711535 SGTC_1182 1222-0449 220 µM -1.91727249914269 0.0154668563909607 no 3256 0.0276016608978646 4680 658318 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.91753359445687 0.0154554183986369 no 3257 0.0275850886450182 4699 16725076 SGTC_3342 9147791 14.508 µM -1.91900813217742 0.0153909584629206 no 3258 0.0274916523407013 4622 1838168 SGTC_1301 naphtanilide LB 4.81 µM -1.92604895183718 0.0150863397283091 no 3259 0.0270491309031889 4698 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1786 berberine 21.6 µM -1.93230181060596 0.01482016989573 no 3260 0.0266611325419064 4590 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1911 st060208 74.3 µM -1.93681104900083 0.0146307373248428 no 3261 0.0263842224021996 4665 688783 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.94209906369994 0.0144112460913248 no 3262 0.0260625544247252 4629 364106 SGTC_1236 0330-0013 258 µM -1.9481394070813 0.0141640020446342 no 3263 0.0256991423367575 4688 4617066 SGTC_121 0557-0495 61.343 µM -1.94848769123153 0.0141498581566344 no 3264 0.0256783181047648 4676 3104427 SGTC_3352 9151559 45.5865 µM -1.94988790907177 0.0140931177769092 no 3265 0.0255947402776498 4669 17159339 SGTC_1080 nisoldipine 24.4 µM -1.95023391943305 0.0140791268094716 no 3266 0.0255741223408238 4703 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2032 5185112 25.99 µM -1.95158520220711 0.0140246021348897 no 3267 0.0254937357608654 4578 5718189 SGTC_2704 st078022 71.1 µM -1.95369516257797 0.0139398285739834 no 3268 0.0253686393668389 4694 54697681 SGTC_584 0986-0246 15.4 µM -1.97683696652494 0.0130386638253608 no 3269 0.0240300308449111 4724 53315 YDR232W HEM1 SGTC_413 propylparaben 100 µM -1.98680935070598 0.0126661311455489 no 3270 0.0234717640072852 4671 7175 A pharmaceutical preservative. SGTC_2756 carbadox 75.1 µM -2.00029983669907 0.0121768556626428 no 3271 0.0227339483281712 4601 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1644 st010134 20.9 µM -2.00061053165406 0.0121657830333291 no 3272 0.0227171888730204 4678 3818134 SGTC_3006 9075424 71.4286 µM -2.00445125723827 0.0120296253175766 no 3273 0.0225108716488948 4653 7465181 SGTC_1065 prochlorperazine maleate 2.48 µM -2.0097450972929 0.0118441200749472 no 3274 0.0222290871399187 4720 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_948 3448-0295 75.3 µM -2.01384000892777 0.0117023346425118 no 3275 0.0220131668363205 4667 678569 SGTC_382 3229-0966 23.2 µM -2.02629502032053 0.0112801003539193 no 3276 0.0213672806284369 4697 5722370 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.03376751995032 0.0110331845070413 no 3277 0.0209875203931255 4676 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2341 7987486 176.74 µM -2.03813724657635 0.0108909838929899 no 3278 0.0207681045744934 4700 1258686 SGTC_2923 7992654 58.14 µM -2.05779054623282 0.0102709642226522 no 3279 0.0198051219817911 4655 2985126 SGTC_2364 9055074 200 µM -2.06174459523485 0.0101500108587112 no 3280 0.0196160292095344 4685 6470630 SGTC_2480 5767542 37.17 µM -2.06584401635374 0.0100259244493026 no 3281 0.0194216052111524 4645 2867358 SGTC_2104 5389443 200 µM -2.07734261148989 0.00968490967999096 no 3282 0.0188849744215719 4709 2244536 SGTC_2614 arthonioic acid 13.39 µM -2.07906216058345 0.00963479394419837 no 3283 0.0188058187311759 4594 6710684 SGTC_364 0083-0097 67.7 µM -2.08539113948673 0.0094522848336132 no 3284 0.0185169052372374 4689 5207356 SGTC_1763 st044482 94.5 µM -2.08590009766491 0.00943774018710472 no 3285 0.0184938367262168 4698 88505 SGTC_3211 9128781 49.47 µM -2.09028854988482 0.00931313996499703 no 3286 0.0182959436066052 4607 17194361 SGTC_3309 9129340 25.759 µM -2.09635643540423 0.00914322795915519 no 3287 0.0180252919483595 4687 17158987 SGTC_2043 5101342 149 µM -2.1094415475073 0.00878603111127395 no 3288 0.0174532432189753 4712 678451 SGTC_2979 9012552 45.46 µM -2.11272092815021 0.00869845090333457 no 3289 0.0173123304732018 4705 17100905 SGTC_1781 st038725 66.3 µM -2.12155525593345 0.00846631650873321 no 3290 0.0169375515790418 4688 4270275 YIL048W NEO1 SGTC_2016 5121758 140 µM -2.12536342777951 0.0083679401542727 no 3291 0.0167781497371484 4642 2795203 SGTC_735 3076-0345 636 µM -2.1257168753309 0.00835886065661691 no 3292 0.0167634204752274 4705 2888990 SGTC_1150 3909-7983 10.9 µM -2.12615970850848 0.00834749719448175 no 3293 0.016744981847265 4720 23965914 SGTC_1514 1189-1591 158 µM -2.13724001448642 0.00806754912070261 no 3294 0.0162892374945231 4706 767698 YMR146C TIF34 SGTC_1934 st074720 32.6 µM -2.17237842588256 0.00723359490699425 no 3295 0.0149135654634176 4672 17250992 SGTC_2344 7990960 76.95 µM -2.18796213362853 0.00688874405154743 no 3296 0.0143361803462626 4688 140813 SGTC_1492 4158-0558 28.5 µM -2.19659650574986 0.00670399389046227 no 3297 0.0140246380047794 4730 3967268 SGTC_2253 7938677 135.83 µM -2.20621865664297 0.00650327944579408 no 3298 0.0136843467987838 4734 2301972 SGTC_650 1328-0195 38 µM -2.22318548649838 0.00616227860551388 no 3299 0.0131016475395061 4726 2780821 SGTC_342 k048-0088 23.3 µM -2.22958449228491 0.00603784356148927 no 3300 0.0128875201601611 4739 6820570 SGTC_433 pimozide 108 µM -2.23424059494233 0.00594870599510376 no 3301 0.0127336233521984 4676 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2990 9074105 71.4286 µM -2.29323849560657 0.00491620709314086 no 3302 0.0109171389976536 4695 6502001 SGTC_2017 5132927 60.65 µM -2.30368929155619 0.00475096179721406 no 3303 0.0106200456936836 4706 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1573 oleylamine 1.06 µM -2.30961227676194 0.00465952458697543 no 3304 0.0104548146563269 4730 5356789 An amine of the fatty acid oleic acid. SGTC_1613 st002381 52.1 µM -2.3178346771436 0.00453519299288116 no 3305 0.010229153846876 4747 551167 SGTC_952 1185-0122 232 µM -2.33607286745171 0.00426992569448246 no 3306 0.00974372206575391 4708 678600 SGTC_2267 7931562 200 µM -2.33858079371401 0.00423455514127107 no 3307 0.00967856988470937 4715 934880 SGTC_600 1495-0418 41.6 µM -2.36195521035842 0.00391728600075885 no 3308 0.00908941918823295 4747 5377768 SGTC_868 0527-0199 213 µM -2.36196465330034 0.00391716225266701 no 3309 0.00908918767038643 4744 2849450 SGTC_1922 5578187 25 µM -2.36521891425643 0.00387472372610148 no 3310 0.0090097080286145 4719 1350412 SGTC_1243 0416-0003 5.65 µM -2.36656820758958 0.00385724887249083 no 3311 0.00897693283548555 4720 2141977 SGTC_2822 7994718 71.43 µM -2.38919298628096 0.00357456837344045 no 3312 0.00844271501932843 4753 1018011 SGTC_2691 st077356 60.2 µM -2.39106964628993 0.00355197762939956 no 3313 0.00839968288318864 4718 2839272 SGTC_58 0957-0393 9 µM -2.42208253187565 0.00319676197140351 no 3314 0.00771592266522153 4310 6997992 SGTC_235 0330-0087 5 mM -2.42991400307749 0.00311227296309425 no 3315 0.00755120287010121 4770 46494818 YHR062C RPP1 SGTC_795 0685-0265 78 µM -2.43281063836086 0.00308153581794276 no 3316 0.00749106697546209 4748 302754 SGTC_1385 3091-4834 14.1 µM -2.45020234041134 0.00290266656377805 no 3317 0.00713879783159993 4736 4072814 SGTC_2028 5153890 36.43 µM -2.45791026063288 0.00282642965341994 no 3318 0.00698740448170058 4746 2830968 YPR165W RHO1 SGTC_3005 9076496 71.4286 µM -2.46780485439329 0.00273121412437381 no 3319 0.00679722043716091 4745 21368410 SGTC_1623 st003709 20.3 µM -2.50273819651405 0.00241776560911134 no 3320 0.00616183335778816 4747 16192618 SGTC_1769 st044406 64.4 µM -2.50911879225592 0.00236416222603702 no 3321 0.00605163870620454 4764 670903 SGTC_1300 1094-0077 113 µM -2.51076203714342 0.00235053265525454 no 3322 0.00602354375813062 4770 5532636 SGTC_2378 9074213 121.43 µM -2.52933872389459 0.00220132505165014 no 3323 0.00571388400830282 4762 657714 SGTC_2070 5230947 200 µM -2.5299606785946 0.00219648144924854 no 3324 0.00570376551257986 4785 2835538 SGTC_516 3992-2719 87.3 µM -2.5415287734074 0.00210813560725557 no 3325 0.00551844307271834 4708 5350887 YDR037W KRS1 SGTC_1581 himbacine 57.9 µM -2.5763740712137 0.00186115043022946 no 3326 0.00499212832411873 4780 5281825 An alkaloid muscarinic receptor antagonist. SGTC_750 4073-0104 132 µM -2.61303904118412 0.00162992807806319 no 3327 0.00448705251029784 4567 22330957 SGTC_1428 4049-0204 61.7 µM -2.63515770775175 0.00150341865355158 no 3328 0.00420490995000726 4786 X1428 SGTC_3097 9117246 49.47 µM -2.64286217796412 0.00146150034270237 no 3329 0.00411042453675142 4781 16423892 SGTC_289 k017-0060 526 µM -2.64739269940558 0.00143735161049433 no 3330 0.00405575485277807 4779 5512909 SGTC_688 0527-0193 473 µM -2.66398340767971 0.00135199613758372 no 3331 0.00386106857363505 4780 4007154 SGTC_1292 0kpi-0043 232 µM -2.67861574909104 0.0012805871841549 no 3332 0.00369635879496818 4784 3333905 SGTC_2001 4023502 57.655 µM -2.68089878371286 0.00126976185577285 no 3333 0.00367123603725275 4764 108941 YCR052W RSC6 SGTC_883 0850-0245 24.6 µM -2.68351085165747 0.00125747907064125 no 3334 0.00364268054221455 4776 6823229 YPR165W RHO1 SGTC_707 0865-0008 204 µM -2.71238624372044 0.00112875648208163 no 3335 0.00334003526197308 4792 723043 SGTC_2087 5276107 200 µM -2.72237870912685 0.00108710222584644 no 3336 0.00324069103153909 4777 144405 SGTC_2966 9084041 48.03 µM -2.73062082816572 0.00105381007530123 no 3337 0.00316075777939468 4755 17741380 SGTC_513 4245-1575 41.7 µM -2.73661686604961 0.00103018086083944 no 3338 0.00310372710104482 4666 719745 SGTC_1293 1000-1278 195 µM -2.74428552972394 0.00100066860800485 no 3339 0.0030321382975307 4777 678847 SGTC_124 0136-0217 7.121 µM -2.77028284594051 0.000906299244077748 yes 3340 0.00280038163995891 4792 3976905 SGTC_692 k241-0027 77.8 µM -2.93340303912295 0.000477967757448458 yes 3341 0.00167634178107497 4792 3600480 SGTC_1844 rapamycin 4 nM -3.13684228546543 0.000205843433395746 yes 3342 0.000853889827030046 4708 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_66 0109-0187 42.4 µM -3.19416098396364 0.000160905262455626 yes 3343 0.000701189454122691 4723 759417 SGTC_677 0929-0063 136 µM -3.36263223265452 7.62509154328047e-05 yes 3344 0.000386015704811872 4807 1539583 SGTC_2299 7976368 114.88 µM -3.41598417619421 5.97641527566286e-05 yes 3345 0.000317759699106965 4791 2979718 SGTC_1298 1079-1278 263 µM -3.48229803428203 4.39390270590342e-05 yes 3346 0.000248565032480826 4800 2840950 SGTC_1759 st043059 70 µM -3.61456117518568 2.34155605733729e-05 yes 3347 0.000150428386420016 4801 669426 SGTC_3345 9148410 3.559 µM -3.71546259664946 1.42817012178624e-05 yes 3348 0.00010141613457664 4798 4903596 SGTC_2311 7694451 200 µM -3.90600294043675 5.42798757676262e-06 yes 3349 4.6917685077882e-05 4800 2163142 SGTC_3350 9150499 3.57 µM -3.96381021261399 4.01214041268006e-06 yes 3350 3.68814513301301e-05 4807 4910996 YPR165W RHO1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -4.020694119053 2.96811831525444e-06 yes 3351 2.90134553008826e-05 4796 5711223 A potent inhibitor of glutathione S-transferases. SGTC_965 1291-5240 308 µM -4.05383398352062 2.48560557980006e-06 yes 3352 2.51924898274715e-05 4801 2834598 SGTC_367 0335-0881 7.1 µM -4.11347033141037 1.80016089129446e-06 yes 3353 1.94877576470667e-05 4801 23828853 SGTC_1526 st051518 75 µM -4.12420220932881 1.69783418968857e-06 yes 3354 1.8601098100954e-05 4806 673993 SGTC_1378 2093-0007 380 nM -4.78555516506915 3.50905210237809e-08 yes 3355 8.52576710731929e-07 4808 3618014 SGTC_3356 9151811 4.48 µM -5.28788094861969 1.2855884269448e-09 yes 3356 6.18707336214598e-08 4808 1859254 YPR165W RHO1