SGTCid condition conc unit HNT2|YDR305C.score HNT2|YDR305C.strain.pval HNT2|YDR305C.strain.significant HNT2|YDR305C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_798 1287-0182 476 µM 6.01341457619662 3.96025680425058e-11 yes 1 9.0827837487731e-10 6 1649755 SGTC_539 4859-0462 2.54 µM 5.50689218118058 1.30333767105272e-09 yes 2 1.8261189347559e-08 5 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1292 0kpi-0043 232 µM 5.4960404674187 1.40014458312011e-09 yes 3 1.94206706798228e-08 3 3333905 SGTC_1527 coumarin 137 µM 5.45114355741787 1.88057115390815e-09 yes 4 2.50234744294878e-08 2 323 A hepatotoxic, DNA x-linker. SGTC_1311 1190-0148 100 µM 4.593850792811 3.3865072609114e-07 yes 5 2.17570281933423e-06 18 1961333 SGTC_427 1354-0053 47.3 µM 4.07245455984377 5.30853800452928e-06 yes 6 2.3260138959727e-05 18 6813657 SGTC_2102 5377816 72.7585 µM 4.0179967408824 6.95276327830721e-06 yes 7 2.93475044147923e-05 28 1379702 SGTC_41 0478-0632 82.643 µM 3.88456909659448 1.32791915576686e-05 yes 8 5.12557683479955e-05 30 3750424 SGTC_39 0986-0283 58.349 µM 3.78861772041367 2.08888015824399e-05 yes 9 7.57439035185896e-05 42 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2308 7584454 197.62 µM 3.63892362098031 4.14902225376248e-05 yes 10 0.000136889988995847 32 893577 SGTC_155 k072-0202 43.6 µM 3.53742931615903 6.51410973128175e-05 yes 11 0.000202021158916812 25 5857737 SGTC_2788 5282734 71.43 µM 3.51032064498366 7.33399933827059e-05 yes 12 0.000223783315498705 70 743706 SGTC_1073 triclabendazole 3.09 µM 3.46979074467557 8.74292025840884e-05 yes 13 0.000260431995549268 45 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2693 st077581 40.7 µM 3.4463796479625 9.66892287765205e-05 yes 14 0.000284075785380919 59 25238761 SGTC_3334 9142812 21.919 µM 3.37331763109567 0.000131865462685743 yes 15 0.000371341127543831 46 45283678 SGTC_705 1124-0212 310 µM 3.26598358200939 0.000205800661967667 yes 16 0.00054542286880459 39 9554485 SGTC_2610 ononetin 44.17 µM 3.23657307556714 0.000231981555938188 yes 17 0.000604871240442091 77 259632 SGTC_2354 9060492 162 µM 3.07165668719895 0.000446085405713247 yes 18 0.00106437203193766 58 6471895 SGTC_227 fluconazole 33.516 µM 3.04665139114025 0.000491294018159352 yes 19 0.00115702957978786 138 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_735 3076-0345 636 µM 3.03056938121264 0.00052257311814794 yes 20 0.00122046549441396 80 2888990 SGTC_296 1222-0039 74.9 µM 3.01590133549771 0.00055269887203867 yes 21 0.00128108308147697 46 5984176 SGTC_3009 9080819 71.4286 µM 2.91698719275337 0.000801618031428156 yes 22 0.0017671514231504 71 17027216 SGTC_2398 5228213 48.84 µM 2.90887299620606 0.000826053233100086 yes 23 0.00181367092410433 116 80771 YMR134W ERG29 SGTC_3330 9141424 71.43 µM 2.8787646913774 0.000922833585433994 yes 24 0.00199618048139304 68 27261020 SGTC_1239 0337-0584 35.4 µM 2.87328384141394 0.000941534049275016 yes 25 0.00203114480613183 123 914301 YML130C ERO1 SGTC_2447 5741742 33.78 µM 2.76288220478544 0.00140059508053272 no 26 0.00286467196375873 93 1776504 SGTC_2808 7946468 45.46 µM 2.73941795629011 0.00152134903434344 no 27 0.00307740371069703 106 2970879 SGTC_2696 st077691 74.316 µM 2.73692774287219 0.00153470659797922 no 28 0.00310079565176768 103 757133 SGTC_1468 k284-1086 134 µM 2.73645068590032 0.00153727771741539 no 29 0.00310529513935997 131 15996457 SGTC_831 k061-1017 217 µM 2.72718750350123 0.00158798706123586 no 30 0.00319383649428012 165 1240153 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 2.71132680178177 0.00167836502816691 no 31 0.00335072705499086 103 6710655 SGTC_299 1273-0059 1.44 µM 2.69966265667409 0.00174779219303492 no 32 0.00347049083724506 83 2848077 SGTC_3234 9132280 49.47 µM 2.68853773681357 0.00181643459523863 no 33 0.00358828617668562 93 17612295 SGTC_744 1594-0068 283 µM 2.67933110187097 0.00187508503612292 no 34 0.00368847043610722 113 668392 SGTC_2021 4019055 173 µM 2.6674530232501 0.00195329554260714 no 35 0.00382142864902534 257 44827708 YER133W GLC7 SGTC_290 2043-6722 48.1 µM 2.63074109500517 0.00221411583182044 no 36 0.00425994572057104 90 773758 YLR208W SEC13 SGTC_307 1501-1223 22.3 µM 2.62545086305599 0.00225419758683663 no 37 0.0043267148933016 75 2830329 SGTC_1556 plumbagin 1.48 µM 2.56741897875564 0.00273906623708504 no 38 0.00512293650722341 81 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_355 1311-2252 105 µM 2.56571791782167 0.00275460226598437 no 39 0.00514812614611192 106 5338538 SGTC_1251 0490-5699 265 µM 2.55932140318181 0.0028137368745587 no 40 0.00524383645225346 136 3883818 SGTC_958 1222-0007 33 µM 2.53089386855065 0.00309063840084698 no 41 0.00568861340939205 133 7312461 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.51295872508043 0.00327772683802936 no 42 0.0059861670673486 197 6708739 YPR165W RHO1 SGTC_896 0964-0007 44.5 µM 2.49797346018128 0.00344178755122749 no 43 0.00624527723535365 85 6756758 SGTC_1203 3992-3522 103 µM 2.46693349276139 0.00380528672810119 no 44 0.00681378330629273 140 5322312 SGTC_811 0416-0114 265 µM 2.45732451259407 0.00392459277623362 no 45 0.00699880900045188 140 6612453 SGTC_2879 9041815 71.43 µM 2.44524546695734 0.00407931529980958 no 46 0.00723767920581483 47 4942971 SGTC_1085 doxorubicin 7.67 µM 2.44114261737043 0.00413309835619459 no 47 0.00732043577696552 137 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1310 1188-0297 994 nM 2.43435576982577 0.00422345910369737 no 48 0.00745916197897887 133 1588352 SGTC_3199 9111318 49.47 µM 2.41120262725825 0.00454516438623263 no 49 0.00795000605395255 133 8548020 SGTC_2019 4016004 108 µM 2.40945690092804 0.00457028536853921 no 50 0.00798814146501941 139 45595336 SGTC_1581 himbacine 57.9 µM 2.40903320352629 0.00457640102912647 no 51 0.00799742135941734 156 5281825 An alkaloid muscarinic receptor antagonist. SGTC_891 0929-0073 133 µM 2.40822882414131 0.00458803156588269 no 52 0.00801506509764141 111 5603632 SGTC_2998 9066762 71.4286 µM 2.40593246357865 0.00462137998833639 no 53 0.00806562327457538 154 4945196 SGTC_2873 9040596 71.43 µM 2.39824996366682 0.00473452546831439 no 54 0.00823680956487308 156 6463863 SGTC_1886 st057356 49.9 µM 2.39736380075035 0.00474773425453527 no 55 0.0082567594525353 122 24207747 SGTC_2625 euphol 100 µM 2.39182736097815 0.00483100479414744 no 56 0.00838236299372785 160 6708538 A triterpene alcohol. SGTC_2057 5236571 38.335 µM 2.37281597738033 0.00512694360688257 no 57 0.00882652830823021 184 54684039 YBR257W POP4 SGTC_2048 5246248 200 µM 2.34458851146755 0.00559612912849897 no 58 0.00952404439264809 85 677046 SGTC_2806 7952793 58.44 µM 2.34369211980937 0.00561163397371971 no 59 0.00954696283990987 139 2972490 SGTC_656 4090-1979 187 µM 2.34205782469252 0.00564000050953978 no 60 0.00958887170021708 155 22330961 SGTC_598 3937-0236 20.2 µM 2.340073879446 0.00567460698724697 no 61 0.00963996279592328 169 1379313 SGTC_1558 st069300 45.6 µM 2.33471562644237 0.00576901634178231 no 62 0.0097791406943378 84 24208000 SGTC_183 3914-0051 30.55 µM 2.33397571720858 0.00578216205527768 no 63 0.00979849672885355 127 1596232 SGTC_3207 9114163 49.47 µM 2.33191123495161 0.00581898166062242 no 64 0.00985268065914505 181 849233 SGTC_3233 9132340 49.47 µM 2.33103758094172 0.00583462563419882 no 65 0.00987568906400795 125 17682950 SGTC_2629 bisabolol 100 µM 2.31805443035389 0.00607154365454487 no 66 0.0102231815407191 159 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1377 2944-0135 198 µM 2.31764394939343 0.00607917123190288 no 67 0.0102343397848704 173 1894137 SGTC_1919 st067113 52.3 µM 2.31579640099531 0.00611360769106361 no 68 0.0102846939204223 172 1268243 SGTC_2006 4011487 200 µM 2.30857157086237 0.0062499365190965 no 69 0.0104836835137838 226 45595294 SGTC_892 0929-0076 29 µM 2.29075976680312 0.00659759852162374 no 70 0.0109886558897872 204 5751038 SGTC_1765 st044815 90.4 µM 2.28347192352577 0.00674470663364139 no 71 0.0112012924290532 144 645695 SGTC_3289 9119912 71.43 µM 2.26686474831529 0.00709080428940206 no 72 0.0116992446363559 164 17014829 SGTC_2143 5623677 140.463 µM 2.2646280523657 0.00713859520942689 no 73 0.0117677569839963 92 5375313 SGTC_1454 4239-0054 42.6 µM 2.26021395894697 0.00723374443881039 no 74 0.0119039874640702 194 1340767 SGTC_1553 gossypol 38.6 µM 2.25720495724812 0.00729924518904076 no 75 0.0119976354055234 62 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1350 1495-0454 146 µM 2.24872249814258 0.00748671658456466 no 76 0.0122650784384336 189 1069057 SGTC_1234 0326-0494 15.5 µM 2.23899786824954 0.00770684907228176 no 77 0.0125780274313219 144 1547813 SGTC_1877 wortmannin 25 µM 2.21275347460201 0.00832960958125434 no 78 0.013457323237548 267 312145 A covalent inhibitor of PI 3-kinase. SGTC_2837 9008476 45.46 µM 2.20678736273071 0.00847719742998613 no 79 0.0136644591771055 202 2992805 SGTC_1905 st060207 84.5 µM 2.19121887529543 0.00887318439841778 no 80 0.0142179786635682 133 1948547 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.17831307424854 0.00921364050479778 no 81 0.0146913682279939 156 803109 SGTC_1489 4065-0444 182 µM 2.17464018412818 0.0093125982827658 no 82 0.0148285452795395 156 2877968 SGTC_1230 0170-0365 3.77 µM 2.16799781540178 0.00949392530557239 no 83 0.015079426376861 299 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_43 0570-0105 72.5 µM 2.16213610162028 0.00965649818606659 no 84 0.0153038435214411 351 1114046 YDL195W SEC31 SGTC_1174 0739-0097 51.1 µM 2.15833161660401 0.00976331170159113 no 85 0.0154510291298033 199 728447 SGTC_2839 9003951 25.97 µM 2.15124003408668 0.0099651700972175 no 86 0.0157286293225217 153 2990634 SGTC_976 1348-1067 47.6 µM 2.1485912045569 0.0100414970010281 no 87 0.015833409758529 204 5310671 YGL099W LSG1 SGTC_390 dec-rvkr-cmk 16.7 µM 2.14734965803761 0.010077447855035 no 88 0.0158827276184928 206 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_888 0916-0002 6.97 µM 2.13442928210016 0.0104582934890068 no 89 0.0164038283700437 185 2802138 YIL048W NEO1 SGTC_212 3807-4682 38.772 µM 2.13115217833127 0.0105568622495051 no 90 0.016538303627053 291 3125501 YBL034C STU1 SGTC_354 2783-3500 4.88 µM 2.13107077547051 0.0105593209529189 no 91 0.0165416559510012 222 6740761 SGTC_335 4077-0256 27.6 µM 2.12678175213491 0.0106895748257602 no 92 0.0167191105828856 185 3121989 SGTC_3319 9138450 16.7555 µM 2.12227286747259 0.0108280121558561 no 93 0.0169074152831128 181 2029690 SGTC_344 k064-0035 6.43 µM 2.0941828714042 0.0117261125227495 no 94 0.0181218465018259 195 5088750 SGTC_2186 6124449 200 µM 2.08975519827656 0.0118734194729255 no 95 0.0183198978784747 189 3834182 YLR033W RSC58 SGTC_442 cape 100 µM 2.08641323384405 0.0119856659600995 no 96 0.0184706036269861 153 5281787 SGTC_1701 st028638 40.4 µM 2.08375682869428 0.0120755419075948 no 97 0.0185911460437741 200 3490878 SGTC_3208 9114115 49.47 µM 2.08132398711411 0.0121583658996544 no 98 0.0187021305093962 225 650895 SGTC_1467 k284-1082 293 µM 2.07454328471502 0.0123918127143116 no 99 0.019014441576 185 3334705 SGTC_1739 st037196 92.5 µM 2.0691597619058 0.0125799124601257 no 100 0.0192655486183281 209 612214 SGTC_1851 st056236 18.9 µM 2.06659784383962 0.0126702902342155 no 101 0.0193860320795915 184 5393171 SGTC_944 3370-0224 231 µM 2.06613688313648 0.0126866112317049 no 102 0.0194077782409352 203 4580514 SGTC_1962 st076595 64.5 µM 2.06486038588422 0.0127319024905111 no 103 0.0194681061279524 209 279619 SGTC_143 4032-1194 15.74 µM 2.06269482936662 0.0128090583832701 no 104 0.019570815745154 280 1806963 SGTC_54 0159-0055 9 µM 2.05785995797301 0.0129827792763961 no 105 0.0198017892407413 200 3319099 SGTC_2191 5911152 200 µM 2.05631994680562 0.0130385392067774 no 106 0.0198758434362552 192 2875902 SGTC_3329 9141233 27.5565 µM 2.04471848527596 0.0134652921556741 no 107 0.0204413100604501 194 4909101 YNL103W MET4 SGTC_694 1315-0438 43.2 µM 2.03678832479062 0.0137638901551167 no 108 0.0208356293975507 160 6793154 SGTC_1715 st032160 10.2275 µM 2.03300917211439 0.0139081865248033 no 109 0.0210257981752189 208 5289825 SGTC_2576 guaiol 23.12 µM 2.03214617495433 0.0139413199945733 no 110 0.0210694300067424 224 227829 SGTC_3016 9080866 49.47 µM 2.02611051045833 0.0141749580895364 no 111 0.0213767306362063 227 17066299 SGTC_2834 9001755 58.44 µM 2.02411360593778 0.0142529965344353 no 112 0.0214792319974325 205 2989575 SGTC_3018 9082602 49.47 µM 2.01436285542033 0.0146393900761713 no 113 0.0219857255927959 225 17332089 SGTC_953 1188-0045 9.7 µM 2.01239171156079 0.014718586472974 no 114 0.0220893307606051 243 6144426 SGTC_972 1319-0219 195 µM 2.01103920884667 0.0147731401326611 no 115 0.0221606577058777 212 23903702 SGTC_2329 6138490 200 µM 1.99924871049442 0.015256124061485 no 116 0.0227907252806067 212 720019 SGTC_381 3461-2219 42.7 µM 1.99735612248157 0.0153349015652983 no 117 0.0228932553514882 216 2883159 SGTC_2840 9008771 71.43 µM 1.99249860824098 0.0155386923967069 no 118 0.0231581888678036 143 2992978 SGTC_1731 st035964 63 µM 1.98783628819414 0.0157364758871491 no 119 0.023414899467657 239 6739575 SGTC_2974 9094440 9.66 µM 1.98137835028092 0.0160139971267461 no 120 0.023774429892606 269 25236134 SGTC_2612 dictamnine 15.46 µM 1.98134056717776 0.0160156330699666 no 121 0.0237765469578506 251 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2486 5283202 22.39 µM 1.98098575555915 0.016031002791339 no 122 0.0237964355188634 229 1377751 SGTC_302 1094-0063 18.9 µM 1.96818580164566 0.0165939879722908 no 123 0.0245233316598986 165 5440289 SGTC_1660 st012960 28.1 µM 1.96709047465522 0.0166429406316185 no 124 0.0245863906039017 251 24207266 SGTC_1359 1582-0056 520 nM 1.96245208291754 0.0168516128777057 no 125 0.0248549370597289 261 3661189 SGTC_1410 3909-8106 77.9 µM 1.95473487594319 0.0172037534506137 no 126 0.0253071856839819 175 1039210 SGTC_1023 4482-3888 16 µM 1.95385122519156 0.0172444732803842 no 127 0.0253594071064081 224 3303168 SGTC_2491 paeonol 100 µM 1.95256570790876 0.0173038586759031 no 128 0.0254355389388369 170 11092 Increases levels of cortical cytochrome oxidase. SGTC_711 k292-0785 179 µM 1.95039010409093 0.0174047602600487 no 129 0.0255648202238149 225 4146315 SGTC_1619 st003326 88.7 µM 1.95006816995789 0.017419733725732 no 130 0.025583997223048 183 2849032 SGTC_2863 9028737 58.44 µM 1.94405136835258 0.0177016114574813 no 131 0.0259446284509325 166 6460917 SGTC_1373 2887-0003 58.5 µM 1.94186400851065 0.0178050460561888 no 132 0.0260767827635035 248 776948 SGTC_813 k007-0158 173 µM 1.93912537292469 0.017935275550037 no 133 0.0262430369103581 286 6523916 SGTC_312 4092-0653 6.84 µM 1.93269438050881 0.0182442833457558 no 134 0.0266369289352491 350 1148278 SGTC_2918 7977171 22.06 µM 1.93121827349328 0.0183158466395029 no 135 0.0267280325603872 227 2236483 SGTC_2461 5755302 26.15 µM 1.93114849120413 0.0183192356734887 no 136 0.0267323458768088 271 2788904 SGTC_2298 7976326 193.81 µM 1.92873778287119 0.0184366421493257 no 137 0.0268817115927187 176 2235818 SGTC_492 tmb-8 126 µM 1.92737373341235 0.0185033576267279 no 138 0.0269665353170823 99 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_512 prima-1 270 µM 1.92523327079751 0.0186084617315946 no 139 0.0271000907544675 233 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2810 7959871 45.46 µM 1.91993466885978 0.0188708298269678 no 140 0.0274330760527956 314 2974535 SGTC_2490 carminic acid 95.39 µM 1.91641514116999 0.0190468384786402 no 141 0.027656137536947 163 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.91503823152405 0.0191160754876111 no 142 0.0277438140619155 268 804 An inhibitor of viral and cellular DNA polymerases. SGTC_70 0141-0289 43.283 µM 1.90805097351031 0.0194707321894006 no 143 0.0281923141901884 513 352408 SGTC_1133 3473-0247 50 µM 1.8843059974936 0.0207180259911749 no 144 0.029761798321467 313 711311 SGTC_495 decylubiquinone 155 µM 1.88142249184837 0.0208740026509754 no 145 0.0299572348251732 255 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_337 1315-0038 354 µM 1.87405856413909 0.0212768544650696 no 146 0.0304611768111713 240 1626437 SGTC_2621 lithochol-11-enic acid 100 µM 1.8651249930765 0.0217743835228076 no 147 0.0310819430253826 296 6708711 SGTC_1788 fluconazole 20 µM 1.86087014373489 0.0220147783670333 no 148 0.0313812584632994 287 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2477 5967686 25.23 µM 1.84297919349247 0.0230502582528094 no 149 0.0326660241959665 278 776118 SGTC_2362 9071156 126 µM 1.84169739438356 0.0231259943799507 no 150 0.0327597127812551 266 653133 SGTC_2991 9074669 71.4286 µM 1.83881531388951 0.0232970498765463 no 151 0.0329711775220507 335 17333109 SGTC_1950 st077106 7.18 µM 1.83834142739684 0.0233252773940261 no 152 0.0330060550981007 290 13831864 SGTC_3004 9076122 71.4286 µM 1.83658985596871 0.0234298614181272 no 153 0.0331352329822399 286 44782551 SGTC_1181 1222-0449 220 µM 1.83467833328549 0.0235444458852043 no 154 0.0332766822304215 259 658318 SGTC_2034 5197015 53.07 µM 1.8280068663842 0.023948060874055 no 155 0.0337742605711257 266 780676 SGTC_1560 lithocholic acid 53.1 µM 1.82659259715085 0.0240343651714711 no 156 0.0338805236335463 168 9903 A bile acid which acts as a detergent. SGTC_462 ag-879 158 µM 1.79649895782167 0.0259336507666287 no 157 0.0362075991561304 321 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_397 arbidol 50 µM 1.79380560814965 0.0261095940259319 no 158 0.0364221007584148 298 131410 A RNA synthesis inhibitor. SGTC_1007 4101-0031 70 µM 1.78137914589288 0.026934331515126 no 159 0.0374252663493461 298 1146276 SGTC_40 0327-0103 19.753 µM 1.77920346550224 0.027080944144953 no 160 0.037603205216081 297 409036 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.77837991548067 0.0271366142119467 no 161 0.0376707395337974 305 5393153 SGTC_1261 0712-0010 12.7 µM 1.77424726270426 0.0274174157015011 no 162 0.0380111298049433 329 2840123 SGTC_2708 st078559 56 µM 1.7716231800017 0.027596968908152 no 163 0.0382285646188602 191 17250902 SGTC_2426 5582046 32.21 µM 1.77044247786104 0.0276780777545256 no 164 0.0383267294018109 318 2251934 SGTC_2035 5154463 94.595 µM 1.76677563659283 0.0279312405529037 no 165 0.0386329052306244 320 2769623 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.76665766842417 0.0279394171247383 no 166 0.0386427883919606 297 4330530 SGTC_2803 7707263 71.43 µM 1.76416180552529 0.0281128774095326 no 167 0.0388523705963527 271 2199229 SGTC_877 0771-0151 33.1 µM 1.76321755598676 0.0281787352859297 no 168 0.0389319019534733 311 6166523 SGTC_164 4100-3994 89.624 µM 1.7614560756352 0.0283019352447248 no 169 0.0390806205722852 373 4615967 SGTC_342 k048-0088 23.3 µM 1.75833586861074 0.0285212664030942 no 170 0.0393451890291126 299 6820570 SGTC_766 1391-0721 126 µM 1.73644209192114 0.0301003517664072 no 171 0.0412428475689495 304 1020919 YIL115C NUP159 SGTC_1427 4048-4900 550 nM 1.73080216618481 0.0305186701776716 no 172 0.0417435277112396 303 24132586 SGTC_1224 0823-0416 294 µM 1.72349156692251 0.0310680593236011 no 173 0.0423998344447453 302 3598164 SGTC_1632 st005650 90 µM 1.71727125263071 0.031541933877827 no 174 0.0429648110040489 315 2759605 SGTC_3044 9093193 49.47 µM 1.71648687051491 0.0316021114651783 no 175 0.043036484494814 358 25236277 SGTC_1317 1273-0028 910 nM 1.71551249168636 0.0316769976634594 no 176 0.0431256535674369 309 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2220 6782180 200 µM 1.71339675652227 0.0318401081198143 no 177 0.043319786302382 203 833803 SGTC_3150 9097574 49.47 µM 1.70930696632907 0.0321573731926355 no 178 0.0436970517951314 257 17217476 SGTC_1784 st039334 36.3 µM 1.70361425646093 0.0326033247205321 no 179 0.0442265881407988 327 3496984 SGTC_219 mitoxanthrone 164.414 µM 1.70197674719251 0.0327325432951302 no 180 0.0443798636546457 342 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_538 2922-0838 53.3 µM 1.70145311615052 0.0327739528865562 no 181 0.0444289672350152 382 777039 SGTC_2229 7354935 190 µM 1.69830731022533 0.0330236383880655 no 182 0.0447248878627084 238 318112 SGTC_3039 9090270 49.47 µM 1.69692218748533 0.0331340728076516 no 183 0.0448556863318446 269 17173750 SGTC_2462 5162487 171.77 µM 1.68617957390973 0.0340009396000428 no 184 0.0458806084579099 332 2259986 SGTC_2493 resveratrol 26.09 µM 1.68616655636634 0.0340020012467876 no 185 0.0458818617447881 251 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.68253786595823 0.0342990040738419 no 186 0.0462322943415769 406 368090 SGTC_1591 genipin 88.4 µM 1.67994326031917 0.0345126733190087 no 187 0.0464841778917172 274 442424 A DNA cross-linking agent. SGTC_2739 tacrine 100.86 µM 1.67622981764464 0.0348203816460745 no 188 0.0468465928916965 295 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_432 NS 1619 61.3 µM 1.6753639438046 0.0348924537593652 no 189 0.0469314232219783 310 4552 A K+/calcium channel activator. SGTC_3177 9107506 49.47 µM 1.67195597460024 0.0351773108544952 no 190 0.0472665018988297 258 8897194 SGTC_3178 9107506 49.47 µM 1.66235917927775 0.0359897293477857 no 191 0.0482203892682891 336 8897194 SGTC_425 3825-7017 13.1 µM 1.6623471350344 0.0359907585299923 no 192 0.0482215960285186 380 3397440 SGTC_2684 capsaicin 100 µM 1.66082960635801 0.0361206245520467 no 193 0.0483738366185777 316 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2219 9098279 200 µM 1.66078563425537 0.0361243932792626 no 194 0.0483782536855412 313 902349 SGTC_657 3534-0529 86.7 µM 1.65984788330126 0.0362048420018869 no 195 0.0484725290649695 339 1049549 SGTC_2351 9026858 72.31 µM 1.65169215692252 0.036910716505277 no 196 0.0492986611718739 305 1409300 SGTC_188 3229-0966 278.469 µM 1.64620511931198 0.0373919187891955 no 197 0.0498607678267393 423 5722370 SGTC_616 4092-0450 108 µM 1.64026998679922 0.0379181743948242 no 198 0.0504745215641354 368 787165 SGTC_1453 4237-0541 195 µM 1.63996174692235 0.0379456696209776 no 199 0.0505065604307006 334 739892 SGTC_1008 4106-0037 6 µM 1.63697322581649 0.0382130922189584 no 200 0.0508180320338207 316 2905394 SGTC_3322 9139058 2.11 µM 1.63615133727604 0.0382869063336173 no 201 0.0509039590471452 350 4908926 YPR165W RHO1 SGTC_298 1391-0729 10 µM 1.62710126855606 0.0391074091260617 no 202 0.0518577958333228 323 3237558 SGTC_1698 5-fluorocytosine 1.055 µM 1.62471963467702 0.0393256971278369 no 203 0.0521111558560236 320 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1725 st036284 20.55 µM 1.62368970132985 0.0394204019676928 no 204 0.0522210250491796 414 707914 SGTC_2010 4012422 159 µM 1.62251379652018 0.039528756001124 no 205 0.0523466907355901 365 952393 SGTC_1658 st012944 20 µM 1.62236307512057 0.0395426617593307 no 206 0.0523628152593225 391 24207260 SGTC_563 tetrahydrosecaminediol 614 µM 1.6220165163257 0.0395746508304677 no 207 0.0523999058788487 374 334274 A psychoactive constituent of the cannabis plant. SGTC_1856 st057054 55.7 µM 1.62075880325643 0.0396909207313492 no 208 0.0525346884544357 375 1266018 SGTC_2909 7941780 10.49 µM 1.61244697263653 0.0404663125602378 no 209 0.0534323551328764 361 1243215 SGTC_1089 terbinafine 2.25 µM 1.60425898666567 0.0412421316040497 no 210 0.0543284887062261 346 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_801 0866-0028 10.1 µM 1.60405045748684 0.041262046295078 no 211 0.0543514654889968 401 6849771 SGTC_1465 k213-0056 144 µM 1.60227514894734 0.0414319054386384 no 212 0.0545473892674302 349 24048857 YMR208W ERG12 SGTC_1330 1469-0054 61.8 µM 1.6015130580844 0.041504994896884 no 213 0.0546316650828291 351 7102664 SGTC_33 0986-0033 35.816 µM 1.59724437893723 0.0419163225664627 no 214 0.0551056219083897 324 2848082 SGTC_3024 9090631 49.47 µM 1.59644325142254 0.0419938853923875 no 215 0.0551949330773121 297 25236383 SGTC_739 1486-1183 203 µM 1.59463826105955 0.0421690650889935 no 216 0.0553965757241946 373 4346692 SGTC_46 0329-0187a 2.197 µM 1.59179116511633 0.0424465858608289 no 217 0.0557158179719166 486 46494817 SGTC_662 k832-1615 104 µM 1.59029549666681 0.0425929669656119 no 218 0.0558841066250544 360 5878478 SGTC_1115 galangin 695.678 nM 1.58931665661435 0.0426889868490319 no 219 0.0559944600421068 405 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2481 5478948 45.16 µM 1.58770686834735 0.042847280448177 no 220 0.0561763196055279 379 77792 SGTC_2968 9090663 33.37 µM 1.57559221056838 0.0440538109092836 no 221 0.0575599062187337 382 25236811 SGTC_1138 3761-0006 1.03 µM 1.57499299274042 0.0441141924636812 no 222 0.0576290309991518 329 12061087 SGTC_536 3852-0578 10.6 µM 1.57281823801041 0.0443338973370531 no 223 0.0578804556848359 359 2869208 SGTC_128 0906-2981 13.371 µM 1.56945698357817 0.0446752023750233 no 224 0.0582707476112042 333 6740226 SGTC_700 3453-2283 142 µM 1.56796860373733 0.0448270083856854 no 225 0.0584442298352978 438 565664 SGTC_2919 7978188 46.38 µM 1.55609202294578 0.046053281334864 no 226 0.0598431058114676 402 2980291 SGTC_2870 9038528 12.99 µM 1.55175505375713 0.0465077403820821 no 227 0.0603604220841639 358 6463316 SGTC_65 0798-0905 34.986 µM 1.54863307606151 0.0468371065593291 no 228 0.060734975031348 522 3602145 SGTC_845 0330-0138 4.51 µM 1.54759983944514 0.0469465233674892 no 229 0.0608593350513349 385 9039800 SGTC_585 0kpi-0023 191 µM 1.54610227949285 0.0471054744527285 no 230 0.0610399341880643 356 64601 SGTC_1741 st038134 10.228 µM 1.54192716897997 0.0475508999648838 no 231 0.0615456464446965 439 1272587 SGTC_1422 4031-0024 15.5 µM 1.54038150239701 0.0477166540998045 no 232 0.0617336937964317 390 782427 SGTC_1700 st030840 7.9285 µM 1.53841255105312 0.0479284701852046 no 233 0.0619738876816712 418 5499307 SGTC_1790 st045711 43.5 µM 1.53463946270698 0.0483364746581608 no 234 0.0624362067719097 397 585119 SGTC_269 exalamide 29 µM 1.52209890150252 0.0497125482030107 no 235 0.0639921506071691 373 3316 A derivative of salicylamide. SGTC_3061 glucosamine 200 µM 1.51923410120608 0.0500312469890872 no 236 0.0643517902484178 364 91431 and experimental redox chemotherapeutic SGTC_1084 voriconazole 435 nM 1.51847019061357 0.0501165038656666 no 237 0.0644479543703099 401 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_440 fluspirilene 35.1 µM 1.51711989450079 0.0502674880677027 no 238 0.0646182081014455 436 3396 An atypical antipsychotic. SGTC_1207 2099-0101 141 µM 1.51627025425045 0.0503626768032539 no 239 0.0647255149588814 449 5837381 SGTC_2843 9000894 45.46 µM 1.51605846243809 0.0503864270738475 no 240 0.0647522851250144 270 2242070 SGTC_3214 9129694 49.47 µM 1.51597796553809 0.0503954563125631 no 241 0.0647624620665646 387 17158655 SGTC_639 0833-0042 114 µM 1.51244420360547 0.050793106305467 no 242 0.0652104484424195 450 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_894 0960-0238 55.9 µM 1.49960604647395 0.0522588334644447 no 243 0.0668582402597932 406 6741907 YDL195W SEC31 SGTC_1804 st050076 49.1 µM 1.4971919363608 0.0525381670827569 no 244 0.0671716614731535 421 3895976 SGTC_175 3793-3120 23.7 µM 1.49610968359744 0.0526637772971084 no 245 0.0673125374270364 387 5322297 SGTC_1912 st060209 90.8 µM 1.49380515043689 0.0529320438131606 no 246 0.0676132774866287 424 688787 SGTC_259 usnic acid 108.925 µM 1.49077229565376 0.0532867434308434 no 247 0.0680106438751753 430 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1050 3232-1156 69.3 µM 1.48809991222948 0.0536008441031522 no 248 0.0683622733162835 443 700529 SGTC_2179 6298986 200 µM 1.48691340525729 0.0537407704674059 no 249 0.0685188416356432 389 738374 SGTC_2444 5485484 36.41 µM 1.48112751726769 0.0544272575582644 no 250 0.0692862982164374 450 6790631 SGTC_1738 st035555 74 µM 1.47709081061998 0.0549103012955719 no 251 0.0698256482462555 449 5331140 SGTC_2675 theaflavin digallate 100 µM 1.47135516874472 0.0556024641113649 no 252 0.0705975453912023 433 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2103 5378138 10 µM 1.47132324344628 0.0556063359597787 no 253 0.0706018601468202 479 244142 SGTC_369 0957-0393 4.5 µM 1.46595645658455 0.0562602415165058 no 254 0.0713300749101852 418 6997992 SGTC_31 0508-1974 57.237 µM 1.46169020757409 0.0567843669076389 no 255 0.0719130609426043 443 6810525 SGTC_738 1315-0003 72.4 µM 1.45844448503255 0.0571856865960517 no 256 0.0723590332696474 461 6251474 SGTC_2389 9091542 195.52 µM 1.45626332239779 0.0574566298264321 no 257 0.0726599202824579 489 3626624 YOL127W RPL25 SGTC_3215 9129942 49.47 µM 1.45087269328436 0.0581305842887377 no 258 0.0734076564609756 391 17682944 SGTC_1575 cyproterone acetate 48 µM 1.44064135963428 0.0594268073807171 no 259 0.0748430147117698 455 9880 An androgen receptor antagonist and liver toxin. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.43716390450921 0.0598724945321601 no 260 0.0753357133143057 325 1241132 A phosphatase inhibitor. SGTC_1141 3253-0389 52.6 µM 1.43516540650788 0.0601298137280993 no 261 0.0756199844150217 424 5402031 SGTC_3155 9099265 49.47 µM 1.43134455772635 0.0606241813541426 no 262 0.0761657448180923 410 25236499 SGTC_2492 derrusnin 100 µM 1.43089730614839 0.0606822570996606 no 263 0.0762298246170335 383 1715307 Part of coumarin class of compounds. SGTC_2811 7967822 32.47 µM 1.42270476315448 0.0617537777911039 no 264 0.0774108796286356 486 2232244 SGTC_2519 cryptotanshinone 88.04 µM 1.41662034290361 0.0625590878132172 no 265 0.0782969788006503 429 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_470 aa-861 153 µM 1.41657477860387 0.0625651492612164 no 266 0.0783036434120808 512 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_491 tetrandrine 80.3 µM 1.41496574089326 0.0627794942696296 no 267 0.0785392705060339 406 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.41421757784494 0.062879354132888 no 268 0.0786490142054743 462 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2707 st078556 66.6 µM 1.41156189502014 0.0632348166697824 no 269 0.0790394994338064 442 17250899 SGTC_1855 st056195 39.6 µM 1.40209384676163 0.0645148567326927 no 270 0.0804436121486395 473 4028379 SGTC_1320 1313-0481 95.3 µM 1.39991046696885 0.0648128774247626 no 271 0.0807700656278008 481 6813365 YLR208W SEC13 SGTC_1508 1080-0625 72.9 µM 1.39833427992635 0.0650286828181338 no 272 0.0810063541956343 437 767111 SGTC_2049 5262831 67.185 µM 1.39698466440437 0.0652139097811446 no 273 0.0812090913981409 476 763417 SGTC_2223 6903751 107.57 µM 1.39583646562851 0.0653718155114787 no 274 0.081381873279482 404 5598863 SGTC_501 nsc-95397 161 µM 1.38554388013669 0.0668005754811667 no 275 0.0829431123655851 454 262093 SGTC_3219 9131112 49.47 µM 1.38529419613154 0.0668355330317172 no 276 0.0829812638494506 467 17612988 YMR079W SEC14 SGTC_2848 9016370 25.97 µM 1.3847213894466 0.0669157835528173 no 277 0.0830688380528224 559 7894410 SGTC_1624 st003710 6.25 µM 1.38088635581468 0.0674549953286217 no 278 0.0836569528923698 555 24207033 SGTC_875 0709-0210 25.7 µM 1.37530584937264 0.0682456138342298 no 279 0.0845183219155896 543 6251364 SGTC_249 wiskostatin 11.211 µM 1.37492743295603 0.0682994838330678 no 280 0.0845769716944273 480 2775510 A n-wasp and actin depolymerizer. SGTC_1946 st076057 65.1 µM 1.37393149427499 0.0684414189079816 no 281 0.0847314755449938 357 953009 SGTC_1349 flufenamic acid 69 µM 1.37207437785627 0.0687066914103318 no 282 0.0850201424120197 470 3371 A non-steroidal anti-inflammatory. SGTC_702 1488-0190 94 µM 1.36896915458747 0.0691520151303905 no 283 0.0855044584970644 479 949357 SGTC_704 1310-0270 142 µM 1.36815983469332 0.0692684452335969 no 284 0.085631025439922 518 5718033 SGTC_1657 st012939 43.4 µM 1.36479336910476 0.0697543717344639 no 285 0.0861590017475399 458 24207257 SGTC_2871 9038510 12.99 µM 1.35782914291804 0.0707679343053361 no 286 0.0872589526270845 527 4945164 SGTC_851 0394-0702 453 µM 1.35006836673079 0.0719107154249394 no 287 0.0884970270596339 552 762646 SGTC_2282 7944268 200 µM 1.34993889011877 0.0719299002782543 no 288 0.088517792847775 553 2970414 SGTC_3343 9148379 18.9835 µM 1.34772269744331 0.0722588875743174 no 289 0.0888737944996165 500 1955036 SGTC_1121 fusaric acid 630.51 nM 1.34735726847869 0.0723132450033106 no 290 0.0889325979996513 524 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1102 cgs 12066b 26.1 µM 1.33804985647773 0.0737083061052163 no 291 0.0904400925105307 473 6438352 A 5-HT1B full agonist. SGTC_1621 st003705 32.4 µM 1.33735162295905 0.0738137862073986 no 292 0.0905539438376418 564 24207032 SGTC_396 dithiazanine 1.25 µM 1.33534701327291 0.0741172578207005 no 293 0.0908813991185451 478 10578 An antihelmenthic. SGTC_3353 9151644 39.2805 µM 1.33346670720778 0.0744027768781485 no 294 0.0911893470117149 536 4909158 SGTC_1813 st051246 8.6015 µM 1.33312753953582 0.0744543677929358 no 295 0.0912449766128218 475 5291959 SGTC_53 0973-0023 39.979 µM 1.32296947705559 0.0760122033437831 no 296 0.0929227642673946 502 674768 SGTC_942 3253-1115 227 µM 1.32187705882531 0.0761812031425797 no 297 0.093104546406464 542 46497897 SGTC_3244 9134489 49.47 µM 1.32163924472319 0.0762180314490059 no 298 0.0931441543006923 526 16584271 SGTC_2125 5246583 200 µM 1.31668875647657 0.0769877530831182 no 299 0.093971486973548 610 835267 SGTC_763 3453-1109 128 µM 1.31190785034676 0.0777367017897183 no 300 0.0947756142162983 543 1560353 SGTC_1689 st020265 53.493 µM 1.31151046101955 0.0777992025628309 no 301 0.0948426809058104 529 5758320 YPR016C TIF6 SGTC_1702 st027038 51 µM 1.31061748004158 0.0779397883561707 no 302 0.0949935152841494 569 5521182 SGTC_248 streptozotocin 5.23457 mM 1.30827872584818 0.0783089018960953 no 303 0.0953893940957522 557 5300 DNA alkylating agent. SGTC_2381 9035592 200 µM 1.30635017867833 0.0786142705654717 no 304 0.0957167500993875 461 4749657 SGTC_333 3486-0131 40.1 µM 1.30603897725416 0.0786636310584503 no 305 0.0957696514939401 537 6744690 SGTC_2859 9028643 45.46 µM 1.30229055304432 0.0792600253030364 no 306 0.0964085399185219 501 17151580 SGTC_2374 9071832 200 µM 1.30015950566265 0.0796006091306938 no 307 0.0967731531586777 508 17381698 SGTC_1496 4469-0713 57.4 µM 1.29673775361637 0.0801497880205796 no 308 0.0973607172740735 555 746691 SGTC_1762 st045503 25.4615 µM 1.29095016875629 0.0810851863193857 no 309 0.0983604786940625 558 4645554 SGTC_1392 3455-1037 33.9 µM 1.2894609111714 0.0813272099097021 no 310 0.0986189486261044 556 981132 SGTC_3262 9137218 49.47 µM 1.28863436892579 0.081461768638277 no 311 0.0987626145464036 380 17650664 SGTC_1041 0206-0046 107 µM 1.28811617548804 0.0815462146466634 no 312 0.0988527627171005 547 50494 SGTC_145 3737-0113 38.366 µM 1.28807003547716 0.0815537369294786 no 313 0.098860792440096 656 6849351 SGTC_1751 st044839 27.194 µM 1.28722930203498 0.0816908947475152 no 314 0.0990071884443454 519 5291326 SGTC_930 2810-3379 265 µM 1.28475768187784 0.0820951235932224 no 315 0.0994384872572061 631 1015764 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.28327101521258 0.0823389898606334 no 316 0.0996985718300524 571 4213774 SGTC_1363 1636-0063 10.4 µM 1.28178733000555 0.0825829105265773 no 317 0.0999586299809299 594 6072185 SGTC_564 3555-0129 330 µM 1.27749909272367 0.0832909624648162 no 318 0.100713050264911 454 563260 SGTC_803 4488-1585 147 µM 1.27663229984247 0.0834346357590248 no 319 0.100866046474496 558 747204 SGTC_620 0109-0052 432 µM 1.27187653690044 0.084226232730331 no 320 0.101708494783294 578 493037 SGTC_3321 9137793 26.8275 µM 1.27133537935617 0.0843166644466374 no 321 0.101804680518478 594 4904192 SGTC_1719 st032227 49.2 µM 1.2692028410736 0.0846737378996026 no 322 0.102184364017384 549 3125804 SGTC_3304 9125678 46.087 µM 1.26613390103308 0.0851895917484678 no 323 0.1027325736049 597 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_633 0437-0093 97.7 µM 1.26314683678074 0.0856939411814404 no 324 0.103268207227226 545 2831118 SGTC_2060 5238662 140 µM 1.25623302786261 0.0868698697734396 no 325 0.104515747682167 554 790130 SGTC_2784 7567673 72.73 µM 1.25598336519415 0.0869125578306324 no 326 0.104561000649668 614 3471247 SGTC_1758 st042942 75.2445 µM 1.25524898400547 0.0870382153297997 no 327 0.104694194250511 568 669317 SGTC_457 grayanotoxin iii 135 µM 1.25168024969729 0.0876507818932215 no 328 0.10534319980385 643 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1370 2001-0092 44.6 µM 1.24762709136972 0.0883503935995105 no 329 0.106083826262091 672 790957 SGTC_2412 st077135 33.4 µM 1.24750230159758 0.0883719992822282 no 330 0.106106688421808 598 13258915 SGTC_1998 st075797 76.8 µM 1.24604469267806 0.0886246564492361 no 331 0.106373993891345 635 24208315 SGTC_758 0868-0029 16 µM 1.2453978706752 0.0887369466608118 no 332 0.106492767812717 582 762687 SGTC_2798 7813637 45.45 µM 1.23824409207936 0.0899859375628315 no 333 0.107812783525223 586 956368 SGTC_2765 myclobutanil 7.74 µM 1.23472978884869 0.0906042700534126 no 334 0.108465542736639 601 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1488 4013-0813 75.9 µM 1.23249163029928 0.0909997087857 no 335 0.108882745611906 535 2910057 SGTC_2164 5685496 200 µM 1.23233001189368 0.0910283130722166 no 336 0.108912916614588 628 759046 SGTC_1209 2323-2347 50.3 µM 1.23191022835723 0.0911026402755433 no 337 0.108991310087044 570 5412760 SGTC_1267 0828-0272 9.49 µM 1.22910615848944 0.0916002859465765 no 338 0.109516003225345 635 745334 SGTC_2487 5918373 44.05 µM 1.22515216589309 0.0923054302293658 no 339 0.110258946679644 634 2876279 SGTC_3105 9121040 49.47 µM 1.22479838368137 0.0923687180613403 no 340 0.110325597060452 357 41448907 SGTC_431 k089-0097 107 µM 1.22373850663425 0.0925585108575604 no 341 0.110525444258411 670 5499420 SGTC_2114 5491910 81.25 µM 1.22285078631908 0.0927176973291754 no 342 0.110693029699965 610 2849228 SGTC_2754 granisetron 64.02 µM 1.21534805396634 0.0940711856922988 no 343 0.112116685651821 621 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_490 phenamil 164 µM 1.21351114439564 0.0944047736193329 no 344 0.112467228085493 490 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3181 9108277 49.47 µM 1.21324105880862 0.0944538953850607 no 345 0.112518835202218 581 17097298 SGTC_1938 st074717 56.4 µM 1.21183708944217 0.0947095456873145 no 346 0.11278737382977 547 17250979 SGTC_751 0833-0568 350 µM 1.20537365151056 0.0958930600077716 no 347 0.114029544216867 622 6954252 SGTC_3068 9116768 49.47 µM 1.2030683517984 0.0963178023008361 no 348 0.114474935609677 565 41904888 SGTC_988 1497-1057 103 µM 1.20133157213042 0.0966387091068125 no 349 0.114811304034059 631 3533044 SGTC_2800 7887935 81.82 µM 1.19818027929644 0.0972229811908614 no 350 0.115423420506639 604 2961002 SGTC_1628 st004252 77.7 µM 1.19816344061465 0.0972261101490972 no 351 0.115426697519489 644 692968 SGTC_424 splitomicin 100 mM 1.19747175053583 0.0973547036353562 no 352 0.115561365988324 587 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1278 0874-0585 172 µM 1.19564820091261 0.0976943214040609 no 353 0.115916936602143 626 766306 SGTC_1117 retinoic acid 1.10837 µM 1.19552929277259 0.097716496978114 no 354 0.115940149231599 682 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1569 carminic acid 40.6 µM 1.19478443057278 0.0978554927737947 no 355 0.116085632450983 649 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2387 9077560 195.08 µM 1.19474323050922 0.0978631851824985 no 356 0.116093683246919 627 5303272 SGTC_2106 5357045 167.29 µM 1.19032203383432 0.0986912387149484 no 357 0.11695992189917 637 668842 SGTC_1090 efavirenz 20.7 µM 1.1831785342426 0.10003997446612 no 358 0.11836919918808 631 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2958 9077254 16.72 µM 1.1821743030833 0.100230653220853 no 359 0.118568273312524 589 16457351 SGTC_1871 st057448 67.3 µM 1.18018521934874 0.100609114067988 no 360 0.118963278182778 667 691747 SGTC_1742 st038235 28.8875 µM 1.17813419354898 0.101000451080496 no 361 0.119371556081016 650 564103 YBR002C RER2 SGTC_2920 7982904 15.77 µM 1.17729123970108 0.101161608529556 no 362 0.119539641125059 565 6456808 SGTC_2193 5925765 200 µM 1.17677354329952 0.101260675507462 no 363 0.119642952534421 578 877370 SGTC_1977 st070720 65.3 µM 1.17671458413373 0.101271962483262 no 364 0.119654722409058 576 682188 SGTC_1212 0520-0165 585 µM 1.17401226275114 0.101790271510359 no 365 0.12019505693931 635 5403258 SGTC_3303 9125618 40.5795 µM 1.17293816931473 0.101996819539694 no 366 0.12041030081986 724 22695467 SGTC_1087 pterostilbene 9.05 µM 1.17229350166725 0.102120935413192 no 367 0.120539619847426 672 5281727 Similar to reservatol, lowers cholesterol. SGTC_321 4534-3890 65.3 µM 1.17148529638099 0.1022766918635 no 368 0.120701882314061 639 699746 SGTC_1501 4491-0275 38.4 µM 1.17012508495549 0.102539220324722 no 369 0.120975317475675 636 5104718 SGTC_1991 st073000 8.92 µM 1.16795611763959 0.102958856083481 no 370 0.121412233064957 698 4301969 YIL048W NEO1 SGTC_2768 sulfasalazine 50.2 µM 1.16623553848908 0.103292627327694 no 371 0.12175961380225 652 5384001 An antioxidant and salicylic acid derivative. SGTC_285 1486-1325 46 µM 1.16494040254729 0.103544385538644 no 372 0.122021558859424 680 22310230 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.16397741575773 0.103731866554647 no 373 0.122216582132139 690 5357218 A potent inhibitor of glutathione S-transferases. SGTC_357 1325-0123 420 µM 1.15551127973954 0.105390721074905 no 374 0.123940558094932 624 1098503 SGTC_1470 k295-0292 231 µM 1.15301549776795 0.105883387217224 no 375 0.124452011733084 694 5045612 SGTC_1677 st019204 53.9 µM 1.14696056916937 0.107085539734044 no 376 0.125698958909955 633 3945625 SGTC_1640 st009078 66.4 µM 1.14404032275984 0.107668834608148 no 377 0.126303457429134 593 690618 SGTC_3045 9092950 49.47 µM 1.14370221605003 0.107736516178977 no 378 0.126373577024045 717 44120432 SGTC_1860 st056228 74.6 µM 1.14250542579599 0.107976333660267 no 379 0.126621996009031 634 688679 SGTC_1666 st014829 29 µM 1.14011779680905 0.108455923948373 no 380 0.127118614217398 690 3858230 SGTC_565 1418-0001 44.5 µM 1.13697774026765 0.109088980864081 no 381 0.127773795630237 713 2862145 SGTC_339 3091-4833 71.4 µM 1.13483410889774 0.109522674169181 no 382 0.128222415968996 681 3240077 SGTC_477 mead ethanolamide 10 µM 1.13358072699196 0.10977682768643 no 383 0.128485230598704 509 16061185 SGTC_3063 1327-0034 4 µM 1.13217127401898 0.110063133764724 no 384 0.128781217268745 654 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2432 5630864 12.22 µM 1.12955112781743 0.11059679411241 no 385 0.129332707108725 663 5714970 SGTC_623 k072-0108 16.9 µM 1.12697878250653 0.111122520286586 no 386 0.129875725924915 674 5382803 SGTC_2533 agelasine 13.65 µM 1.12023527130091 0.112509222182393 no 387 0.131306758591867 718 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_271 rotenone 740 µM 1.11900652500913 0.112763221064635 no 388 0.131568677686911 707 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_214 4373-3496 70 µM 1.11652342736599 0.113277760871225 no 389 0.132099073937208 863 3779166 SGTC_842 0271-0008 11.1 µM 1.11572275793025 0.113444029661421 no 390 0.132270412974328 744 1221709 SGTC_3231 9132313 49.47 µM 1.11528335414907 0.113535351155869 no 391 0.132364508142736 694 4905967 SGTC_1499 4480-0877 67.3 µM 1.11500052254184 0.113594159903056 no 392 0.132425098901714 646 2861909 SGTC_2476 5806916 10.51 µM 1.11459067238653 0.113679417957306 no 393 0.132512934641289 669 2870194 SGTC_660 4031-1742 102 µM 1.11305862397546 0.11399852242764 no 394 0.132841626189181 715 6738706 SGTC_2926 9010726 65.15 µM 1.10890521922796 0.114866827856434 no 395 0.133735536027483 672 2994293 SGTC_632 0781-2353 4.65 µM 1.10830951150464 0.114991750490724 no 396 0.133864084554421 724 6811515 YHR007C ERG11 SGTC_1750 st081859 2.357 µM 1.10761197208806 0.115138150467707 no 397 0.134014715381883 853 5291695 SGTC_1815 st051655 58.2 µM 1.10625041345224 0.115424296873031 no 398 0.134309073916457 672 5984156 SGTC_374 0880-0231 82.3 µM 1.10437678842731 0.115818885281214 no 399 0.134714862693392 704 6833587 SGTC_987 1497-1013 404 µM 1.10382901609814 0.115934427764188 no 400 0.134833657727196 672 1676435 SGTC_1257 0669-0121 16 µM 1.10133031976698 0.116462519790029 no 401 0.135376459920211 765 4307855 SGTC_2251 lansoprazole 556 µM 1.10047478349212 0.116643726360086 no 402 0.135562655337642 553 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2214 7179297 48.276 µM 1.09942917234735 0.116865463042346 no 403 0.135790456036869 707 769744 SGTC_2457 5731572 11.68 µM 1.09939536226241 0.116872637933992 no 404 0.13579782639965 713 2865357 SGTC_3111 9122088 49.47 µM 1.09449807742461 0.117915198442901 no 405 0.136868295060807 584 16876704 SGTC_2714 st079313 56.9 µM 1.09346209884104 0.118136583744296 no 406 0.137095480593741 693 2939799 SGTC_1343 1487-0095 224 µM 1.09147581699908 0.118561867531552 no 407 0.137531783628384 709 4560101 YGL055W OLE1 SGTC_1076 itraconazole 331 nM 1.089397814292 0.119007946508177 no 408 0.137989247426026 730 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2275 7947463 200 µM 1.0880517788369 0.119297527828507 no 409 0.138286124894734 679 1225414 SGTC_1561 5-methoxyflavone 52.9 µM 1.08143869258538 0.12072746648362 no 410 0.139751008994946 678 94525 SGTC_1814 st052110 31.539 µM 1.08071887635352 0.120883836409666 no 411 0.139911091885527 694 674163 SGTC_1552 6-methylflavone 10.6 µM 1.08026147807824 0.12098327376452 no 412 0.140012879300109 671 689013 SGTC_108 0509-0257 621.132 µM 1.07985282081972 0.121072163599463 no 413 0.140103862652671 764 536624 SGTC_159 3970-0959 50 µM 1.07950890052926 0.121147007649799 no 414 0.140180464102505 927 6615653 SGTC_3032 9089427 49.47 µM 1.07458387325071 0.122222364860786 no 415 0.141280537587565 695 17173707 SGTC_3052 9092717 49.47 µM 1.07125746575316 0.122952451591271 no 416 0.14202683957413 695 25237534 SGTC_2287 7945887 168.79 µM 1.07121738470412 0.12296126726551 no 417 0.14203584826971 780 1245853 SGTC_936 3005-4620 401 µM 1.07027560467565 0.123168535749354 no 418 0.14224763593123 803 777207 SGTC_2002 4023503 131 µM 1.07002811278392 0.123223044773349 no 419 0.142303327389772 845 4736863 YCR052W RSC6 SGTC_1324 1418-0026 34.4 µM 1.06813103059213 0.123641430407183 no 420 0.142730705112676 750 1372513 SGTC_190 3970-0790 3.722 µM 1.06568152046571 0.124183119416379 no 421 0.143283817015036 715 2832352 SGTC_1125 tnp00248 1.32998 µM 1.06437462418772 0.124472806981823 no 422 0.143579512284968 876 24207736 SGTC_2318 6029776 164 µM 1.06363478174575 0.124637010279634 no 423 0.143747089748486 733 818325 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.06313358251022 0.124748334236853 no 424 0.143860688464838 751 688667 SGTC_3055 9094636 49.47 µM 1.06219921498984 0.124956056926828 no 425 0.144072628076953 708 25236176 SGTC_1279 0874-0590 65.2 µM 1.06194039753496 0.125013638300669 no 426 0.144131372036779 772 3523074 SGTC_1238 0333-0287 48.8 µM 1.06127728623852 0.125161251014517 no 427 0.144281952509924 726 7226 SGTC_2126 5251174 33.877 µM 1.06126096922594 0.12516488481708 no 428 0.144285659141992 830 790722 SGTC_910 3454-3003 490 µM 1.05926189587761 0.125610636449222 no 429 0.144740261619437 749 820824 SGTC_485 niflumic acid 177 µM 1.05916758581193 0.125631692951329 no 430 0.144761732152895 701 4488 A COX2 inhibitor. SGTC_2771 fluoxetine 41.05 µM 1.05788677553735 0.125917901877279 no 431 0.145053532481602 711 3386 A selective serotonin reuptake inhibitor. SGTC_1824 st053723 68.6 µM 1.05386064729466 0.126820537434352 no 432 0.145973361089078 743 675225 SGTC_996 3970-0799 1.8 µM 1.05290037157669 0.127036489638837 no 433 0.14619332789914 937 6615648 YGL040C HEM2 SGTC_511 blebbistatin 171 µM 1.04934230515354 0.127838877887088 no 434 0.14701030088139 742 3476986 A myosin inhibitor. SGTC_1568 digitonin 820 nM 1.04875807790097 0.12797096428823 no 435 0.147144738239863 798 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2292 7671323 168.05 µM 1.0475051731027 0.128254549863666 no 436 0.14743332376627 756 937504 SGTC_1587 estradiol valerate 56.1 µM 1.04662673033143 0.128453638830213 no 437 0.147635884280597 766 13791 A steroid. SGTC_2255 7941087 197.44 µM 1.04611310589047 0.12857014524743 no 438 0.147754407490297 837 935561 SGTC_3238 9133470 49.47 µM 1.04430661445586 0.128980497631781 no 439 0.148171776799157 759 3534688 SGTC_1650 st011916 45.8 µM 1.04282632227499 0.129317428819186 no 440 0.1485143689773 764 242528 SGTC_1643 st009866 20.2 µM 1.04258642309866 0.129372089963251 no 441 0.148569940001263 761 3156273 YOR207C RET1 SGTC_2757 clomiphene 4.22 µM 1.04185994739831 0.129537715454534 no 442 0.148738307977633 846 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2709 st078560 56 µM 1.04062952231009 0.129818568771119 no 443 0.149023762053775 780 17250903 SGTC_1003 4049-0218 100 µM 1.0399402520724 0.129976083750139 no 444 0.149183830026817 781 295161 SGTC_1211 1056-0033 32.3 µM 1.03865218794021 0.130270792174274 no 445 0.149483262477963 795 6741922 SGTC_561 1550-0330 72.9 µM 1.03808647508406 0.130400372991208 no 446 0.149614898757558 727 6812934 SGTC_3288 9119690 36.221 µM 1.0373134216411 0.130577590856963 no 447 0.14979490635546 694 17595618 YKL019W RAM2 SGTC_884 0851-0618 334 µM 1.03328809518034 0.131503063656913 no 448 0.150734548382041 793 9642473 SGTC_268 camptothecin 39.6153 µM 1.03081811103873 0.132073180235836 no 449 0.151313061769899 860 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_96 0929-0093 37.281 µM 1.03081472085008 0.132073963921589 no 450 0.151313856824723 738 6991579 SGTC_2654 protoveratrine a 100 µM 1.0307493638325 0.132089072664403 no 451 0.151329184660025 760 5702278 A heart drug and vasodilator. SGTC_531 3788-1495 174 µM 1.03060477060077 0.132122502873005 no 452 0.151363099014486 734 2896655 SGTC_8 0354-0001 70 µM 1.02730467431329 0.132887077184791 no 453 0.152138511019971 870 4993152 SGTC_3165 9101544 49.47 µM 1.02682286114295 0.13299895917334 no 454 0.152251941246238 778 5002184 SGTC_2563 tomatine 8.54 µM 1.02478848929124 0.133472076130822 no 455 0.152731499421595 821 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_876 0720-0963 56.8 µM 1.02464582811249 0.133505297035483 no 456 0.152765166190961 817 765861 SGTC_551 k048-0028 34.9 µM 1.0229086266034 0.133910288064002 no 457 0.15317552517054 830 6836383 SGTC_2088 5278280 127.392 µM 1.02196946812874 0.134129583839528 no 458 0.153397675630585 806 791502 SGTC_170 4197-0004 226 µM 1.01754018757471 0.135167156188895 no 459 0.154448262270318 720 218692 SGTC_420 mitomycin C 81.9 mM 1.01736078046556 0.135209298497844 no 460 0.154490916067421 781 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2015 5119600 184 µM 1.01414444975147 0.135966335548797 no 461 0.155256915364377 796 2828786 SGTC_193 1273-0060 1.558 µM 1.01288728961939 0.136263024279455 no 462 0.155557000089626 685 2847393 YHR072W ERG7 SGTC_115 0527-0192 112.043 µM 1.01243676041239 0.136369456535627 no 463 0.155664634692697 877 4233931 SGTC_2113 5491891 107.031 µM 1.00956523655058 0.137049156784022 no 464 0.156351815949165 800 789979 SGTC_2430 5571206 200 µM 1.00824181579642 0.137363193281168 no 465 0.156669193935493 880 1731771 SGTC_27 0485-0001 32.618 µM 1.00824012788884 0.137363594120796 no 466 0.156669598993979 727 2054479 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.00653536845729 0.137768843509056 no 467 0.157079053464864 810 688798 SGTC_2799 7812892 81.82 µM 1.00527993956077 0.138067800725306 no 468 0.157381035915971 838 20205235 SGTC_1413 3910-0535 34.4 µM 1.00496089423687 0.138143845929729 no 469 0.157457840253323 835 2876951 SGTC_3116 9124943 49.47 µM 1.00480091917502 0.138181987110996 no 470 0.15749636060005 729 41905195 YPL160W CDC60 SGTC_1652 st011932 78 µM 1.0044626769537 0.138262654305 no 471 0.157577826229923 787 1551076 SGTC_2350 9023895 38.85 µM 1.00178212253438 0.138903073479939 no 472 0.158224416695188 783 2997209 SGTC_250 brefeldin a 552.239 µM 1.00134927452147 0.139006675583919 no 473 0.158328989256756 697 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_286 k060-0067 22.9 µM 0.999421270812685 0.139468781881984 no 474 0.158795329973531 783 5985051 SGTC_83 0170-0301 39.027 µM 0.998930677610134 0.139586534443248 no 475 0.158914136985609 735 3089716 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.996098713204386 0.140267586116181 no 476 0.159601092521165 815 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_162 k030-0015 37.8 µM 0.994743215447909 0.140594363522039 no 477 0.1599305851661 860 1809920 YMR134W ERG29 SGTC_3318 9139014 38.6185 µM 0.990387612962099 0.141647888731489 no 478 0.160992348818532 777 16643984 SGTC_2037 5169046 200 µM 0.987591515662856 0.142327015142797 no 479 0.161676371572219 782 5718022 SGTC_938 3126-1755 342 µM 0.986489537572784 0.142595271835515 no 480 0.161946473412051 859 1777771 SGTC_643 k048-0106 28.4 µM 0.985048721169497 0.142946528054941 no 481 0.162300069849203 816 6763920 SGTC_2180 6301957 200 µM 0.984566658183408 0.143064180484863 no 482 0.162418486951338 849 845462 SGTC_1191 1487-1166 10.6 µM 0.983599461514145 0.14330043204436 no 483 0.162656245007729 906 3955771 SGTC_1506 4226-2149 212 µM 0.982494765858667 0.143570591832278 no 484 0.162928080153908 877 991114 SGTC_515 4092-1064 102 µM 0.977745000256146 0.144736089797779 no 485 0.164100229612242 883 717353 SGTC_2967 9089538 49.85 µM 0.974309771106472 0.145582986886405 no 486 0.164951377272531 840 728216 SGTC_1649 st011737 51.3 µM 0.9742349861419 0.145601460826516 no 487 0.164969938502393 812 1761035 SGTC_331 k048-0133 24.5 µM 0.973807208809284 0.145707163870678 no 488 0.165076136550215 775 6813582 SGTC_2355 9061122 103.12 µM 0.971547472343735 0.146266396751977 no 489 0.165637862629797 823 5302957 SGTC_3040 9091894 49.47 µM 0.971009796847395 0.146399671089346 no 490 0.165771700023683 761 25236966 SGTC_122 0236-0016 402.397 µM 0.970417581997895 0.146546558493748 no 491 0.16591919416027 900 6808838 SGTC_1697 st025554 27.742 µM 0.969568657170877 0.146757290300129 no 492 0.166130771113722 803 1269519 SGTC_1718 roemerine 11.9335 µM 0.963800793816135 0.148194450385654 no 493 0.167572904313559 844 235224 An aporphine alkaloid with mutagenic activity. SGTC_25 0118-0223 35.662 µM 0.963462170600466 0.148279115700565 no 494 0.167657819816648 841 5333628 SGTC_1756 st041558 35.5 µM 0.963301821859233 0.148319218676743 no 495 0.167698039644628 926 3955792 SGTC_3142 9086498 49.47 µM 0.95853742082106 0.149514098693889 no 496 0.168895915615172 782 25236367 SGTC_2685 mycophenolic acid 18.85 µM 0.954294668690446 0.150583545981503 no 497 0.169967252960599 842 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3175 9106517 49.47 µM 0.953122277848162 0.15087996035227 no 498 0.170264059912345 822 41468073 SGTC_2099 5377090 177.372 µM 0.952573207341798 0.151018914736284 no 499 0.170403178805715 828 2243829 SGTC_2157 5649910 96.377 µM 0.952098987440229 0.151138995043949 no 500 0.170523391254764 837 2858091 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.95096423671341 0.151426590467103 no 501 0.170811265443256 834 5379071 SGTC_309 k408-0051 1.48 µM 0.948814305627808 0.151972474193147 no 502 0.171357532352809 899 3640463 SGTC_716 1683-5115 658 µM 0.94839558433516 0.152078942584259 no 503 0.171464053264647 948 723597 SGTC_2273 7815444 169.05 µM 0.947470638831063 0.152314304290588 no 504 0.171699505410962 835 2824616 SGTC_1192 1488-0095 21.4 µM 0.946893301517749 0.15246133609063 no 505 0.171846575801184 822 915875 SGTC_3211 9128781 49.47 µM 0.943249360612613 0.153391519547975 no 506 0.172776685503342 799 17194361 SGTC_2766 oltipraz 83.91 µM 0.943217927233475 0.153399559820809 no 507 0.172784722753235 831 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2666 tannic acid 100 µM 0.942490428738532 0.153585723013257 no 508 0.172970804559213 892 16134267 A thiamine antagonist. SGTC_1917 st066507 28.5 µM 0.942189655785115 0.153662732987256 no 509 0.173047774484224 869 3156428 SGTC_587 k089-0003 57 µM 0.940161139521142 0.1541827823059 no 510 0.173567455807049 753 9659696 SGTC_2452 5863136 48.41 µM 0.939384587717299 0.154382174124956 no 511 0.173766661575172 849 2184096 SGTC_2393 9031399 185.94 µM 0.938529667316609 0.154601885383476 no 512 0.173986139045314 875 1526623 YDL150W RPC53 SGTC_255 tunicamycin 200.472 nM 0.938230684347851 0.154678771605753 no 513 0.174062936338937 871 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3354 9151612 71.43 µM 0.937108577412727 0.15496755705637 no 514 0.174351354876688 892 27261949 SGTC_2614 arthonioic acid 13.39 µM 0.933581452177964 0.155877615312316 no 515 0.175259918294743 817 6710684 SGTC_2642 cholecalciferol 100 µM 0.93230688108622 0.156207341201996 no 516 0.175588976302752 888 9821465 A vitamin D precursor, similar to steriods. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.932208249945526 0.156232875781828 no 517 0.175614456368798 904 23847180 SGTC_318 1488-0629 67.2 µM 0.93217143613554 0.156242407200277 no 518 0.175623967335869 831 3662576 SGTC_378 3970-0959 8.33 µM 0.930859655576529 0.156582288714994 no 519 0.175963083104642 863 6615653 SGTC_2697 mebhydrolin 72.4 µM 0.928600924578125 0.157168664298974 no 520 0.176547971271538 906 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2324 6149169 200 µM 0.925639929530274 0.157939534854658 no 521 0.177316567620596 845 2888231 SGTC_1143 3454-2408 5.08 µM 0.925470893215264 0.157983616840823 no 522 0.177360508655987 865 X1143 SGTC_2876 9059903 25.97 µM 0.922967709947371 0.15863735270982 no 523 0.178012016396828 925 6916095 SGTC_1941 st076221 61.8 µM 0.922880414729931 0.158660182848862 no 524 0.178034764067057 919 2828568 SGTC_2141 5621638 7.665 µM 0.921726694814718 0.158962115219282 no 525 0.178335576295633 896 2856238 SGTC_923 1900-2434 73.3 µM 0.919973739604728 0.159421589642072 no 526 0.178793241178807 863 5910570 SGTC_663 1486-0733 13.9 µM 0.919862380914147 0.159450807677437 no 527 0.17882233987259 899 722445 YPR165W RHO1 SGTC_1504 k297-0033 30 µM 0.917979226571696 0.159945436216336 no 528 0.179314870779396 757 4388117 SGTC_1180 1193-0155 285 µM 0.917522281672301 0.160065608305546 no 529 0.179434511236624 843 2921347 SGTC_669 0108-0021 26.2 µM 0.916865922296501 0.160238327751261 no 530 0.179606451553466 982 17201 SGTC_847 0342-0274 5.54 µM 0.915907218774176 0.16049082719436 no 531 0.179857780132153 926 18097 SGTC_2407 paclitaxel 400 µM 0.911553146574273 0.161640854321093 no 532 0.181001998159476 903 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1047 2043-3044 82 µM 0.91096802335137 0.161795809471594 no 533 0.181156111144133 922 669592 SGTC_3297 9117502 71.43 µM 0.91047729210091 0.161925841894344 no 534 0.181285426004944 916 7453720 SGTC_2645 abamectin 100 µM 0.908151026646849 0.162543174426116 no 535 0.181899217176489 878 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1409 3909-8004 61.9 µM 0.907934809356267 0.162600630755362 no 536 0.181956332610207 920 2119279 SGTC_3237 9133362 49.47 µM 0.905370313761265 0.163283112569643 no 537 0.182634618641119 906 43845137 SGTC_3101 9120531 49.47 µM 0.904821922843187 0.163429295461272 no 538 0.182779867764379 914 24824904 SGTC_71 0417-1750 47.813 µM 0.89848731234158 0.165124052916463 no 539 0.184462903179278 941 6811472 SGTC_1491 4138-0063 26.5 µM 0.898132428312917 0.165219333694166 no 540 0.184557476197005 903 23883227 SGTC_749 1000-0129 128 µM 0.897624377251683 0.165355799330911 no 541 0.184692919159186 977 708470 SGTC_2659 sanguinarine 24.21 µM 0.895702967986881 0.165872560925457 no 542 0.185205712414889 872 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2716 st080858 38.6235 µM 0.894758504508059 0.166126955918714 no 543 0.185458098359673 968 5296050 SGTC_314 1671-0008 2.74 µM 0.894087475905212 0.166307853217664 no 544 0.185637544836386 936 3913060 SGTC_3025 9087895 49.47 µM 0.893579853470639 0.166444783621724 no 545 0.185773364783022 968 17173641 SGTC_1217 1183-1422 255 µM 0.892194516990518 0.166818846362346 no 546 0.186144340283084 975 2849664 SGTC_34 0469-0683 81.75 µM 0.891333018707832 0.167051737795796 no 547 0.186375269955143 930 3690923 SGTC_1907 st060210 83.7 µM 0.886391206979098 0.168391720974737 no 548 0.18770337790598 991 688793 SGTC_1931 st074438 57.1 µM 0.885667666876245 0.16858848899861 no 549 0.187898318205241 918 2787313 SGTC_421 streptovitacin 30 mM 0.885324655703065 0.168681823123714 no 550 0.18799077789484 947 91467 include heat shock SGTC_2856 9022925 19.48 µM 0.881579719332129 0.169702988835047 no 551 0.189002063179725 908 4944862 SGTC_2360 9040895 200 µM 0.880973991673234 0.169868529841823 no 552 0.189165948594404 871 4914414 SGTC_1214 0358-0031 63.7 µM 0.880935500411906 0.16987905272389 no 553 0.189176365729665 891 4301366 SGTC_2271 7849410 118.62 µM 0.87943863440116 0.170288595577141 no 554 0.18958174604804 933 972430 SGTC_2741 miltefosine 3.04 µM 0.879013053241848 0.170405150055237 no 555 0.189697099174847 845 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_676 falcarinol 140 µM 0.876363454660334 0.171131948062271 no 556 0.19041623949072 982 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_622 1348-1566 26.3 µM 0.876248257030912 0.171163592247391 no 557 0.190447543765425 986 7340407 SGTC_1679 SEC14.276 6.7 µM 0.874184773093481 0.171731054204249 no 558 0.19100881850426 998 1005053 YMR079W SEC14 SGTC_1435 4092-0789 56.7 µM 0.873817765760654 0.171832107639505 no 559 0.191108751926264 957 2248285 SGTC_594 1487-1584 10.8 µM 0.870470596504223 0.172755484049667 no 560 0.192021640554039 957 5013332 SGTC_852 0418-0143 439 µM 0.869758388474679 0.172952366693588 no 561 0.192216228045933 1020 5369229 SGTC_1098 clofazimine 15.1 µM 0.86922870160928 0.173098885888075 no 562 0.192361025799161 968 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1626 st003712 1.76 µM 0.869221093658489 0.173100990935196 no 563 0.192363106031029 876 24207035 SGTC_1277 0873-0036 22 µM 0.866167515528207 0.173947203244906 no 564 0.19319915234174 983 5965735 SGTC_3316 9136639 10.545 µM 0.865328615640298 0.174180140293408 no 565 0.19342922449721 956 4903665 SGTC_934 2950-0684 338 µM 0.865115654835003 0.174239304585174 no 566 0.193487656570003 993 1121253 SGTC_2309 7664088 163.95 µM 0.864183588797809 0.174498399313719 no 567 0.193743523023142 993 704922 SGTC_3082 9117008 49.47 µM 0.86341624530495 0.174711888200617 no 568 0.193954325349569 955 41448529 SGTC_3008 9078912 71.4286 µM 0.86110305982993 0.175356461229884 no 569 0.194590642054087 933 16648731 SGTC_2647 atorvastatin 60.16 µM 0.860014638222454 0.175660272688501 no 570 0.19489048671599 944 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_452 diindolylmethane 8 µM 0.858894914127093 0.175973169436854 no 571 0.195199247800181 884 3071 Inhibits expression of several cancer promoting factors. SGTC_2819 7996655 46.38 µM 0.857967445722892 0.176232609129452 no 572 0.195455219819861 858 6456960 SGTC_1071 trifluoperazine 6.31 µM 0.856978683024538 0.176509461054408 no 573 0.195728332863784 981 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_775 4577-0580 57.3 µM 0.856198035341515 0.176728235338737 no 574 0.195944124563551 968 2006902 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.85320793359754 0.177567787756896 no 575 0.196772002285327 1022 688788 SGTC_1136 pergolide 1.05886 µM 0.85319657646494 0.177570981371698 no 576 0.196775150798687 957 47811 A dopamine receptor agonist. SGTC_2678 equilin 100 µM 0.852661698185401 0.177721429685503 no 577 0.196923468501407 1006 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.852604480621537 0.177737528361569 no 578 0.196939338505398 961 616764 SGTC_1281 0884-0031 11.8 µM 0.851959587184134 0.177919038545501 no 579 0.197118261268061 967 1548255 SGTC_602 3130-1533 38.1 µM 0.850972475202481 0.178197095073046 no 580 0.197392321455397 1006 720941 SGTC_1680 diphenhydramine 100 µM 0.847957781735976 0.179047989174128 no 581 0.198230741560525 937 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_80 0159-0065 512.242 µM 0.84400093225704 0.180168678297567 no 582 0.199334442328459 920 1548079 SGTC_2827 7993847 71.43 µM 0.842940552794145 0.18046975354464 no 583 0.199630845950493 899 2985692 SGTC_3170 9103054 49.47 µM 0.84286062712687 0.180492459751693 no 584 0.199653197995322 926 16432970 SGTC_2936 9038235 15.59 µM 0.842313363496245 0.180647980866302 no 585 0.199806286418608 1006 4749415 SGTC_1018 4259-0013 28.1 µM 0.840416669645757 0.181187632422188 no 586 0.20033740294712 973 6801262 SGTC_1882 5615643 20 µM 0.838847324148678 0.181634908642386 no 587 0.200777495222631 959 2253075 SGTC_2796 7949634 45.45 µM 0.83839835529052 0.181762995415677 no 588 0.200903506430932 919 2971588 SGTC_1147 3809-1045 12.3 µM 0.838267469191174 0.181800346676744 no 589 0.200940250907066 965 325925 SGTC_111 0083-0039 52.457 µM 0.837133692595008 0.182124095961098 no 590 0.201258711830765 912 759313 SGTC_2312 7706453 155.7 µM 0.835956894970524 0.182460510793977 no 591 0.201589576549087 954 976098 SGTC_2699 st077704 54.6 µM 0.835324533873696 0.182641446083046 no 592 0.201767503725748 973 645852 SGTC_465 cgp-37157 41 µM 0.833732874196564 0.183097357831314 no 593 0.202215764401506 898 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_435 c-PAF 6.7 µM 0.831539727330592 0.183726720285421 no 594 0.202834397594569 990 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1796 st049173 110.4 µM 0.830307507859239 0.184080918171924 no 595 0.203182472147236 954 94134 SGTC_2435 5706476 10.6 µM 0.83003781225653 0.184158498049358 no 596 0.203258702679532 1035 5725375 SGTC_1817 st052116 64.4 µM 0.829052909945332 0.184441985099284 no 597 0.203537234180099 980 4361398 SGTC_2130 NSC 7 2.4545 µM 0.828978679525998 0.184463362033228 no 598 0.203558235848937 1028 21448 SGTC_1403 3909-7815 62.9 µM 0.826050196262587 0.185307938306303 no 599 0.204387808916593 975 6615483 SGTC_1420 4'-methoxyflavone 42 µM 0.824796788736765 0.185670154335654 no 600 0.204743485063473 1024 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_943 3253-1379 105 µM 0.824638025923948 0.185716065737654 no 601 0.204788563022363 973 668464 SGTC_1027 k015-0025 8.67 µM 0.8230749435779 0.186168457479812 no 602 0.205232688306453 1013 3598955 SGTC_1312 1218-2183 165 µM 0.821147334343366 0.186727291203689 no 603 0.205781175444247 1045 6744073 SGTC_2243 6634756 200 µM 0.820653814403251 0.186870534498666 no 604 0.205921742670153 962 885676 SGTC_266 formosanin C 406 nM 0.81935544375112 0.187247708958718 no 605 0.206291824099512 1017 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1699 st031318 29.054 µM 0.818850984124535 0.187394380506586 no 606 0.206435719152584 1050 5340658 SGTC_57 miconazole 162.5 nM 0.81322729406839 0.189034272535469 no 607 0.208043876679335 982 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1323 1348-1351 11.2 µM 0.81239949552112 0.189276406294147 no 608 0.208281217809522 974 6989654 SGTC_617 3770-0098 35 µM 0.812279990889435 0.189311377551643 no 609 0.208315494606999 980 5962639 SGTC_2933 9026794 32.47 µM 0.812212187402328 0.189331221004682 no 610 0.208334943754483 990 17586027 SGTC_1748 st037455 53.6035 µM 0.811752570681509 0.189465766760216 no 611 0.208466811131561 1000 580690 SGTC_99 0109-0120 622.8 µM 0.809826292905139 0.190030294861125 no 612 0.209020009399566 1005 759414 SGTC_645 0845-0943 5.41 µM 0.808530621947792 0.190410593962389 no 613 0.209392592651662 985 1885106 SGTC_2167 5876490 200 µM 0.806531043873947 0.190998416977474 no 614 0.209968357806346 1042 686534 SGTC_1258 0671-0043 57.1 µM 0.804855749801567 0.19149176498454 no 615 0.210451463035353 1049 4298767 SGTC_2182 6325192 200 µM 0.804140673986766 0.191702581204883 no 616 0.210657868259601 985 736248 SGTC_2260 7964312 200 µM 0.803948865662107 0.19175915364948 no 617 0.210713253549579 969 231951 SGTC_439 amiodarone 34.4 µM 0.803087326339601 0.1920133843475 no 618 0.210962131219352 1023 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_443 clozapine 122 µM 0.800738510263982 0.192707540979856 no 619 0.211641521604097 956 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2790 5423970 71.43 µM 0.800359700068875 0.192819635956649 no 620 0.211751211505321 1049 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_911 3456-4043 236 µM 0.799840264119012 0.192973408708693 no 621 0.211901675675377 1065 914281 SGTC_2780 5215298 71.43 µM 0.799629335250781 0.193035873032169 no 622 0.211962792949828 1064 2834131 SGTC_3308 9128332 17.569 µM 0.796137703274315 0.194071675327188 no 623 0.212976000883067 1080 17332805 YDL196W YDL196W SGTC_1770 st043884 66.3 µM 0.795915139804238 0.194137813992433 no 624 0.213040680412143 1081 670149 SGTC_1988 st071872 53.4 µM 0.795485264458697 0.194265597905646 no 625 0.213165639617976 1059 16414116 SGTC_2581 avocatin a 64 µM 0.794959868439266 0.194421845646678 no 626 0.213318423486463 1028 6710728 A skin care supplement. SGTC_2594 a-mangostin 100 µM 0.794345868719351 0.194604540190091 no 627 0.213497053971401 1052 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2738 aclarubicin 5.55 µM 0.79127162982691 0.195520844558056 no 628 0.214392749997662 962 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1113 artemisinin 1.17947 µM 0.789634097474315 0.196009993412113 no 629 0.214870744525636 1087 2240 An anti-malaria and mitochondrial poison. SGTC_1590 st077108 57.8 µM 0.789206971375626 0.196137702621893 no 630 0.214995524047715 1051 5489485 SGTC_2583 asiatic acid 100 µM 0.787805332311919 0.196557142167859 no 631 0.215405290779399 1063 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2640 pentamidine 10.38 µM 0.787436496943801 0.196667606158927 no 632 0.215513194407859 1101 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2694 st077685 81.9 µM 0.786975844054872 0.19680562174831 no 633 0.215648003479459 1061 2838096 SGTC_1146 3579-1023 7 µM 0.786422597049832 0.196971456832889 no 634 0.215809974623416 1101 X1146 SGTC_2174 5790901 200 µM 0.786103115451972 0.19706725954967 no 635 0.215903539634565 1040 786020 SGTC_2518 prenyletin 46.28 µM 0.784755312387524 0.197471734618764 no 636 0.216298522781868 987 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2724 maprotiline 69.64 µM 0.784520355881786 0.197542296301421 no 637 0.216367421227334 1069 4011 A tricyclic antidepressant. SGTC_1954 st077032 68.9 µM 0.784244266683001 0.197625230351334 no 638 0.216448397619541 1016 698907 SGTC_1570 verbenone 133 µM 0.784091292277259 0.197671191179642 no 639 0.21649327224668 1064 29025 A natural terpanoid with antifungal properties. SGTC_1268 0828-0275 2.46 µM 0.783204438381694 0.197937771775388 no 640 0.216753534481181 1093 745337 SGTC_3310 9130229 44.1445 µM 0.780734887025037 0.198681240953491 no 641 0.21747921863296 1038 7761258 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.780588881900194 0.198725249090321 no 642 0.21752216648774 1187 688664 SGTC_2211 7117706 200 µM 0.774332459479639 0.200616546232266 no 643 0.219367106563792 1041 822771 SGTC_3224 9130643 49.47 µM 0.772466191891284 0.201182799073329 no 644 0.21991918157297 1080 17644395 SGTC_2140 5586273 200 µM 0.771652438546969 0.201430003475877 no 645 0.22016015362638 1099 854421 SGTC_1408 3909-7976 48.8 µM 0.771651159679352 0.201430392117285 no 646 0.220160532449164 1127 24152374 SGTC_3270 9137563 49.47 µM 0.77145551031469 0.201489854264003 no 647 0.220218491589952 1032 17015724 SGTC_288 1315-0019 35.1 µM 0.769463718296829 0.202095802073184 no 648 0.220809037520433 1091 6811474 SGTC_1522 st012842 45.6 µM 0.768439148635843 0.202407923420306 no 649 0.221113164787625 967 3491067 YOR116C RPO31 SGTC_2 0422-0095 29 µM 0.767061270091099 0.202828129747949 no 650 0.221522543858812 1007 6790840 SGTC_1487 3970-0795 2.82 µM 0.766146874629914 0.203107276881171 no 651 0.221794457276775 1097 3765103 SGTC_1001 4048-4355 44.4 µM 0.765885684374095 0.203187055277625 no 652 0.221872162314174 1062 21824233 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.765461925163153 0.203316528797113 no 653 0.221998265268513 1156 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_468 gf-109203x 121 µM 0.76471923275875 0.203543566478663 no 654 0.22221937555875 1010 2396 A protein kinase C inhibitor. SGTC_1369 1866-0067 208 µM 0.763652369141801 0.203869966307749 no 655 0.222537216127791 1120 3531355 SGTC_2644 guaiazulene 100 µM 0.760212220906592 0.204924579417901 no 656 0.223563870579893 1110 3515 A coloring agent. SGTC_1519 esterone 74 µM 0.760050355860142 0.204974280593876 no 657 0.223612242748521 1097 698 A steroid. SGTC_560 2332-1943 155 µM 0.758397322065067 0.205482260015255 no 658 0.224106580278059 1103 21177716 SGTC_3027 9089541 49.47 µM 0.758378771159444 0.205487964970816 no 659 0.224112131421105 1102 9943819 SGTC_995 3931-2021 34.6 µM 0.7583451239625 0.205498312725219 no 660 0.224122200153277 1062 730143 SGTC_2763 lisinopril 49.32 µM 0.757409788667091 0.205786086662574 no 661 0.22440219673686 1059 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2047 4141938 200 µM 0.757301986078292 0.205819269569072 no 662 0.224434480653505 1056 3807862 SGTC_540 1187-0821 17.3 µM 0.75669800494017 0.206005240789836 no 663 0.224615405174439 1063 847520 SGTC_2622 2-methoxyxanthone 59.94 µM 0.756538107559464 0.206054491309593 no 664 0.22466331680402 1116 71034 A hepatoprotective. SGTC_1831 st055328 12 µM 0.751960738007684 0.20746734081263 no 665 0.226037335078628 1115 1103068 SGTC_3081 9117243 49.47 µM 0.751278729793161 0.207678338311493 no 666 0.226242463668201 1112 45595589 SGTC_2906 7926292 26.41 µM 0.750964444824545 0.207775613436323 no 667 0.226337026997678 1107 2966319 SGTC_955 1216-0110 33 µM 0.750821448524912 0.207819881484304 no 668 0.226380059689896 1066 3619719 SGTC_505 gw-5074 63.9 µM 0.750447907031268 0.207935546787531 no 669 0.226492493461002 1087 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.749890728234397 0.208108145100389 no 670 0.226660259544119 1157 6728940 SGTC_872 0588-0139 234 µM 0.748368511134372 0.208580115976367 no 671 0.227118955231813 1154 2047100 SGTC_895 0964-0006 13.7 µM 0.748077444110391 0.208670434549816 no 672 0.227206723165743 1106 6738897 SGTC_687 k029-0044 34.9 µM 0.746736240274061 0.209086910033658 no 673 0.227611394741792 1145 5829338 SGTC_2278 7948257 134.34 µM 0.746653720335817 0.209112550398731 no 674 0.227636306121356 1106 1247028 SGTC_712 r015-0009 80.6 µM 0.746388728221016 0.209194900527404 no 675 0.227716313156206 1058 6813872 YLR060W FRS1 SGTC_1456 k015-0012 13 µM 0.746141566462299 0.209271726820773 no 676 0.227790951073027 1194 2989616 SGTC_2983 9022671 12.99 µM 0.74555569742098 0.209453901198962 no 677 0.227967926811993 1077 6405161 SGTC_3041 9091929 49.47 µM 0.74327119184947 0.210165152670336 no 678 0.228658754606976 1201 25236887 SGTC_1895 st058434 18.3 µM 0.743149906343331 0.210202952970775 no 679 0.22869546382249 1152 5393175 SGTC_714 4296-0578 26.1 µM 0.741961969202652 0.210573401000732 no 680 0.229055189008124 1136 1589775 SGTC_922 1866-0035 480 µM 0.741365296180213 0.210759612821911 no 681 0.229235990237998 1147 3156169 SGTC_322 k048-0136 19.3 µM 0.737934599663277 0.211832149395984 no 682 0.230277096153731 1139 6823282 SGTC_569 4130-2812 160 µM 0.737118982229458 0.212087604438775 no 683 0.230524998272134 1043 743552 SGTC_1780 st038448 24.544 µM 0.736373762481156 0.212321168015727 no 684 0.230751633769103 1125 728868 YDL195W SEC31 SGTC_3292 9120825 59.784 µM 0.736043756017949 0.212424645228622 no 685 0.2308520347559 1162 24824900 SGTC_1834 st055981 52.8 µM 0.734696936586713 0.2128472609057 no 686 0.231262043207796 1137 471719 YDL150W RPC53 SGTC_1266 0828-0227 32.9 µM 0.734530534120432 0.212899510031571 no 687 0.231312728822965 1089 3913820 SGTC_2456 5770359 74.46 µM 0.733844654566808 0.213114950062578 no 688 0.231521710751193 1150 3118787 SGTC_3286 9117135 37.221 µM 0.733532059269356 0.2132131808156 no 689 0.231616990904772 1123 3438150 SGTC_1139 k015-0024 46.9 µM 0.733497075726675 0.21322417577697 no 690 0.231627655372028 1140 2766652 SGTC_2602 kawain 100 µM 0.733489923162508 0.213226423793749 no 691 0.23162983581058 1150 5369129 SGTC_368 fentichlor 4.58 µM 0.733442723398538 0.21324125880082 no 692 0.231644224809274 1097 7329 A pesticide. SGTC_3235 9132602 49.47 µM 0.731879554221318 0.213732906831325 no 693 0.232121043259441 1175 4912240 SGTC_1039 k821-0043 94 µM 0.73182388824707 0.213750427061643 no 694 0.232138033295887 1139 15992768 SGTC_1899 st063254 59.6 µM 0.730995617426278 0.214011214655463 no 695 0.232390914927342 1087 3093813 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.730932168312769 0.214031199742883 no 696 0.232410293066496 1095 77254 SGTC_552 k242-0005 476 µM 0.730905673291828 0.214039545418322 no 697 0.232418385237558 1151 4088318 SGTC_2162 5663267 200 µM 0.730000459192839 0.214324792869499 no 698 0.232694951959003 1154 6456493 SGTC_761 k216-0224 480 µM 0.729705239655478 0.214417869063146 no 699 0.232785188833184 1186 1340404 SGTC_2915 7971052 15.16 µM 0.72752897314586 0.215104722709408 no 700 0.233450986624418 1034 5741558 SGTC_1177 0983-0204 23.6 µM 0.726105346696929 0.215554725144879 no 701 0.233887095779344 1170 766818 SGTC_281 1672-3440 14.9 µM 0.725907575574759 0.215617282940991 no 702 0.233947716041042 1164 6833000 SGTC_1893 st059353 36.1 µM 0.725880272491219 0.215625920118425 no 703 0.233956085591031 1126 3112488 SGTC_713 1488-1073 324 µM 0.725511520975227 0.215742592243777 no 704 0.234069139775873 1134 3312542 SGTC_2836 9010338 19.48 µM 0.725370064261002 0.215787358530222 no 705 0.234112516503103 1092 2994051 SGTC_2119 5528445 120.635 µM 0.724522923634046 0.216055562655514 no 706 0.234372379473046 1137 791935 SGTC_1428 4049-0204 61.7 µM 0.724204752713693 0.216156345203037 no 707 0.234470020591813 1191 X1428 SGTC_234 nsc-17383 10.7 µM 0.722395302583005 0.216730016813351 no 708 0.235025737062652 1182 408974 SGTC_3185 9108267 49.47 µM 0.720655802003097 0.217282340636232 no 709 0.235560655976772 1147 4910486 SGTC_1579 chlormadinone acetate 49.4 µM 0.719922426792323 0.217515444313719 no 710 0.235786379455911 1176 45114258 A steroidal progestin. SGTC_518 1021-0119 62.6 µM 0.719538635132906 0.217637490198145 no 711 0.235904553122941 1096 1097762 SGTC_1287 0971-0001 34.6 µM 0.719514377528989 0.217645205452312 no 712 0.235912023402345 1153 4665869 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.719300674918553 0.217713181472469 no 713 0.235977840078891 1139 2374 Ca(2+)-ATPase inhibitor. SGTC_1450 4112-4260 37.6 µM 0.719075155632378 0.217784929505026 no 714 0.236047307057976 1154 1633175 SGTC_216 k038-0035 28.382 µM 0.718003465775686 0.218126069576877 no 715 0.236377574930505 1106 4444231 YPR107C YTH1 SGTC_1588 farnesol 29.9 µM 0.717313258270942 0.218345939227605 no 716 0.23659041413641 1157 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2835 9006588 71.43 µM 0.715881547280093 0.218802426017238 no 717 0.237032246707348 1148 2345538 SGTC_3277 9138724 49.47 µM 0.714808941685376 0.219144775151249 no 718 0.237363554601409 1052 15943418 SGTC_784 4579-0127 173 µM 0.712687265765679 0.219822867856495 no 719 0.238019649066684 1213 1948547 SGTC_3137 9097352 49.47 µM 0.712199664579458 0.219978876388207 no 720 0.238170572319297 1266 44120435 SGTC_1920 st075728 45.7 µM 0.710775495672948 0.220434904360409 no 721 0.238611683888918 1160 3400306 SGTC_2948 9070189 9.45 µM 0.709737764782554 0.220767533379783 no 722 0.238933384385053 1083 6473636 YDL196W YDL196W SGTC_2131 toluylene red 5.2905 µM 0.709413303385174 0.220871593553585 no 723 0.239034017292311 1151 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1793 st048256 72.231 µM 0.709067014424614 0.220982685163467 no 724 0.239141445655388 1115 672022 SGTC_1923 st058458 19.1 µM 0.708247422387213 0.221245742669398 no 725 0.239395810753057 1217 3534982 SGTC_394 menadione 8.33 µM 0.707978455011804 0.221332109867454 no 726 0.239479318515385 1150 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_570 0987-0065 62.6 µM 0.700590772879273 0.223711869468487 no 727 0.241779219216458 1071 3104428 SGTC_2468 5987765 72.9 µM 0.700037533188719 0.223890665581789 no 728 0.241951932491225 1203 26772094 SGTC_252 miconazole 1.30953 nM 0.699213451138472 0.224157143095212 no 729 0.242209322798505 1145 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_134 0269-0018 6.916 µM 0.699155530655086 0.224175879199708 no 730 0.242227419018645 1110 4378915 SGTC_604 1000-0114 314 µM 0.697226537501133 0.224800377269298 no 731 0.242830516890144 1223 1572745 SGTC_186 3455-3465 67.277 µM 0.696502234132535 0.225035119913631 no 732 0.243057179314095 1144 755278 SGTC_84 0443-0269 128.823 µM 0.695950722684559 0.225213954782713 no 733 0.243229845194858 1164 6150058 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.69449111466767 0.225687640194934 no 734 0.243687135557114 1175 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2977 9011197 71.43 µM 0.694293275489737 0.22575188813291 no 735 0.243749153619638 1172 2704722 SGTC_2434 5670830 169.91 µM 0.693505575689118 0.226007794884577 no 736 0.243996163984948 1189 1549830 SGTC_865 0488-0499 301 µM 0.693417343106789 0.226036469965707 no 737 0.244023840753413 1232 9634651 SGTC_2744 captopril 92.04 µM 0.692036810724463 0.226485402775595 no 738 0.244457106170195 1162 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1059 3448-6867 171 µM 0.691586343947453 0.226631998110079 no 739 0.244598570013562 1192 3934407 SGTC_79 0052-0007 94.094 µM 0.691263339780078 0.226737146267155 no 740 0.244700032844502 1237 2801472 SGTC_2648 atorvastatin 78.68 µM 0.691011551885007 0.22681913034579 no 741 0.244779140767001 1215 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_856 0433-0016 11.3 µM 0.690236809806675 0.227071497205294 no 742 0.245022639258138 1210 3911780 SGTC_2764 methyldopa 94.69 µM 0.690096530899039 0.227117209008101 no 743 0.245066742314625 1216 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_48 0382-0018 55 µM 0.688849226974827 0.227523888128544 no 744 0.245459076757907 1313 762596 SGTC_1979 st071809 45.3 µM 0.688810956653347 0.227536372515192 no 745 0.245471119867986 1254 4976333 SGTC_863 0466-0191 129 µM 0.688219993419784 0.227729203071761 no 746 0.245657127644932 1217 765160 YPR165W RHO1 SGTC_1240 0356-0016 42.1 µM 0.688174904887852 0.22774391917854 no 747 0.245671322527762 1171 4305613 SGTC_1811 st050069 61.5 µM 0.687601303733937 0.227931179255306 no 748 0.245851943496197 1194 3877702 SGTC_2546 rhodinyl acetate 100 µM 0.686139662050277 0.228408743896798 no 749 0.246312521123607 1194 6708682 SGTC_2689 tacrolimus 100 µM 0.685787517131224 0.228523884786974 no 750 0.246423554543228 1212 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_678 1218-2179 85.9 µM 0.685054777860421 0.228763573158388 no 751 0.246654677608171 1212 6820081 YOR116C RPO31 SGTC_548 1436-0017 110 µM 0.684888657753292 0.228817932785418 no 752 0.246707091905439 1263 9677137 SGTC_2336 9001819 198.65 µM 0.683961481579309 0.229121466584418 no 753 0.246999744495104 1261 2989602 SGTC_3176 9106582 49.47 µM 0.681313754205271 0.229989507042835 no 754 0.247836491037971 1127 17018027 SGTC_1825 st052143 62.6 µM 0.679875287482 0.230461869643205 no 755 0.248291715226389 1231 674173 SGTC_2311 7694451 200 µM 0.678874254910947 0.230790907703442 no 756 0.24860876973855 1178 2163142 SGTC_2352 9027995 87.8 µM 0.678420996562749 0.230939979367328 no 757 0.248752400008829 1190 2997347 SGTC_2030 5175110 200 µM 0.67707441295921 0.231383172780415 no 758 0.249179371160363 1257 2831986 SGTC_1665 st014639 11.4 µM 0.676256357278352 0.231652646231699 no 759 0.249438948277355 1292 981133 YIL048W NEO1 SGTC_2497 7-hydroxyflavone 100 µM 0.675546337323618 0.231886673639814 no 760 0.249664361038295 1219 5281894 SGTC_1968 st069590 43.6 µM 0.674962260612613 0.232079287971115 no 761 0.249849871189419 1184 6384066 SGTC_2385 9074692 200 µM 0.673984826790435 0.232401821081253 no 762 0.250160480147959 1215 17046906 SGTC_1222 0366-0074 1.18 µM 0.673523240560198 0.23255422169579 no 763 0.250307234203969 1258 286520 SGTC_869 0564-0080 44.1 µM 0.673093438491978 0.232696178168092 no 764 0.250443924014057 1219 6843321 SGTC_172 1112-0046 2.638 µM 0.672371529736434 0.232934720965696 no 765 0.250673601412957 1168 2802135 YIL048W NEO1 SGTC_395 anisomycin 6.25 µM 0.671584725910253 0.233194861885649 no 766 0.250924052364713 1190 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2009 4012297 12.05 µM 0.671509039314357 0.233219894641839 no 767 0.250948151475305 1224 45595307 SGTC_1469 k284-2957 126 µM 0.671063318761782 0.233367343518351 no 768 0.251090096678066 1251 23884841 SGTC_2525 harmine 47.85 µM 0.67088568743959 0.233426120170865 no 769 0.251146677395901 1203 5280953 A monoamine oxidase inhibitor SGTC_1119 parthenolide 318.541 nM 0.6702551199469 0.233634835751173 no 770 0.251347585843657 1312 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3203 9113543 49.47 µM 0.669986410846554 0.233723808932409 no 771 0.251433226482912 1262 17018012 SGTC_1620 st003704 16.5 µM 0.669092971565541 0.234019773644007 no 772 0.251718086566615 1227 2834414 SGTC_1610 st001799 48.1 µM 0.668288167331394 0.234286554336557 no 773 0.25197483249066 1175 621897 SGTC_2524 avocatin b 10.57 µM 0.668198067631719 0.234316431527966 no 774 0.25200358439106 1180 6710748 SGTC_2884 9058502 51.95 µM 0.668144728525262 0.234334119846896 no 775 0.252020606358716 1233 6471554 SGTC_2403 6032726 181.2 µM 0.66771220691671 0.23447757998821 no 776 0.252158658235132 1240 2881040 SGTC_666 0272-0154 136 µM 0.667696527593965 0.234482781468274 no 777 0.252163663496974 1263 6870312 SGTC_23 0213-0011 39.996 µM 0.667303198493992 0.234613285888708 no 778 0.252289241875734 1267 627608 SGTC_807 1315-0151 48 µM 0.667190299417641 0.234650752596524 no 779 0.25232529330986 1267 4011080 SGTC_1630 st005209 31.3 µM 0.666379208507111 0.234920018620997 no 780 0.252584374280858 1251 3367314 SGTC_3200 9114385 49.47 µM 0.665493078908797 0.235214391067422 no 781 0.252867584427081 1228 17018030 YLR208W SEC13 SGTC_3153 9100258 49.47 µM 0.664193042945378 0.235646631672146 no 782 0.253283382810239 1205 25236848 SGTC_2226 7298446 200 µM 0.66405737402964 0.235691764590374 no 783 0.253326795326587 1245 3283010 SGTC_2008 4012253 172 µM 0.663794936664665 0.235779083041253 no 784 0.253410783411227 1258 603940 SGTC_2917 7979103 53.79 µM 0.663751312207246 0.235793599547782 no 785 0.253424746007081 1250 2980565 SGTC_1805 st050013 60.3 µM 0.663737260330286 0.235798275565618 no 786 0.253429243585875 1205 4037144 SGTC_3064 1327-0027 10 µM 0.662991381552122 0.236046553674207 no 787 0.253668036912079 1147 16000455 YPR107C YTH1 SGTC_1514 1189-1591 158 µM 0.66118384400371 0.236648819536817 no 788 0.254247210427756 1284 767698 YMR146C TIF34 SGTC_658 3253-0951 102 µM 0.659813133982706 0.237106098842037 no 789 0.254686876909634 1250 1184878 SGTC_370 0180-0345 38.7 µM 0.659790677343607 0.237113594588004 no 790 0.254694083374262 1208 3989527 SGTC_2074 5212007 75.395 µM 0.659745185603377 0.237128779562375 no 791 0.254708682262549 1193 758611 SGTC_2108 5365811 200 µM 0.657914235182104 0.237740387331209 no 792 0.255296621474195 1280 780283 SGTC_2159 5658611 73.75 µM 0.656630394135698 0.238169755124147 no 793 0.255709300313203 1277 793844 SGTC_802 4112-3352 742 µM 0.6566036853582 0.238178692116934 no 794 0.255717889299806 1317 704594 SGTC_2253 7938677 135.83 µM 0.655416990714075 0.238575956011863 no 795 0.256099657555098 1318 2301972 SGTC_1476 4112-3294 3.34 µM 0.654205994288542 0.238981728897755 no 796 0.256489550101229 1298 704369 SGTC_2985 9022375 71.43 µM 0.654030693510897 0.239040498802652 no 797 0.256546015570623 1298 4939335 SGTC_81 0411-0046 9.971 µM 0.653602379751729 0.239184124999333 no 798 0.256684005325145 1158 12925265 SGTC_2441 5730946 39.09 µM 0.653193521032072 0.239321271331071 no 799 0.256815763296558 1282 1774275 SGTC_2769 toremifene 3.73 µM 0.652535678808757 0.239542026069127 no 800 0.25702783204006 1279 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2123 5259487 200 µM 0.651758414616127 0.239802998922593 no 801 0.25727851621405 1237 2173474 SGTC_262 fenpropimorph 62.5 µM 0.651458546277661 0.23990372363675 no 802 0.257375264069454 1215 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2823 7987624 58.44 µM 0.651344614744142 0.239941998884074 no 803 0.257412027261987 1296 2239440 SGTC_102 gallobenzophenone 83.616 µM 0.650199575265941 0.24032685924658 no 804 0.257781657692366 1335 70837 SGTC_600 1495-0418 41.6 µM 0.64931430864171 0.240624637461399 no 805 0.258067619503978 1276 5377768 SGTC_2319 6033012 152.6 µM 0.649305502654648 0.240627600550583 no 806 0.258070464869756 1221 847246 SGTC_2986 9022445 71.43 µM 0.649237402342344 0.240650516006166 no 807 0.258092469800573 1239 6459286 SGTC_301 4119-0100 24.5 µM 0.648693715560963 0.240833506808805 no 808 0.258268183615992 1265 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1688 st021091 57.6 µM 0.648383576328484 0.240937925492548 no 809 0.258368445099717 1270 3656366 SGTC_3344 9148862 3.898 µM 0.648042909425314 0.241052650705631 no 810 0.258478598774708 1314 4905352 SGTC_1134 3477-0009 42.5 µM 0.645617336219785 0.241870360612549 no 811 0.259263603603568 1356 3973534 SGTC_50 0929-0078 56.389 µM 0.645230300909982 0.242000977152682 no 812 0.259388976371004 1207 1377751 SGTC_147 4466-0538 29.23 µM 0.645104269227986 0.242043518536095 no 813 0.259429808709322 1337 6742687 YHR072W ERG7 SGTC_3100 9120536 49.47 µM 0.644670771913007 0.24218987441384 no 814 0.259570280558575 1173 16421196 SGTC_209 4077-0173 175.592 µM 0.644342388407552 0.242300774054661 no 815 0.259676717131417 1225 15993494 SGTC_82 0054-0107 293.755 µM 0.643869057229827 0.242460672934482 no 816 0.259830174174473 1285 3104697 SGTC_2262 9014885 67.46 µM 0.641076792068675 0.243405107122961 no 817 0.260736395874118 1231 6457424 SGTC_2073 5212005 126 µM 0.64104039856245 0.243417429689991 no 818 0.260748218010797 1182 691789 SGTC_311 1315-0136 58 µM 0.639192414413542 0.244043586074448 no 819 0.261348883116401 1338 6759207 SGTC_720 r052-1644 49.9 µM 0.639138074197364 0.244062011424967 no 820 0.26136655650332 1262 1422863 YOR257W CDC31 SGTC_1247 0448-0043 5.84 µM 0.639122264528779 0.244067372212287 no 821 0.261371698489745 1320 3089013 YGL099W LSG1 SGTC_1976 st070609 63.5 µM 0.636691893839508 0.244892224004636 no 822 0.262162777359504 1237 682556 SGTC_2479 5617353 43.85 µM 0.636348464488462 0.245008902514469 no 823 0.262274661503951 1332 2731746 SGTC_844 0330-0132 15.3 µM 0.636128446622967 0.245083668265813 no 824 0.262346352884815 1278 2828079 SGTC_2327 6189656 200 µM 0.636096529513869 0.245094515252546 no 825 0.262356753699305 1338 5349088 SGTC_1618 st003135 44.5 µM 0.633954939373786 0.245822921350529 no 826 0.263055114865663 1240 1270615 SGTC_2089 5281248 129.67 µM 0.633711472204709 0.245905803864793 no 827 0.263134568314673 1311 2737878 SGTC_3283 9109332 35.8195 µM 0.633709051306664 0.245906628076327 no 828 0.263135358415813 1223 17027281 SGTC_2415 st077333 57.7 µM 0.633410390530444 0.246008320581875 no 829 0.263232840723919 1367 2766255 SGTC_3284 9108171 64.8615 µM 0.632925206454495 0.246173571428804 no 830 0.263391243196244 1270 8687505 SGTC_2586 curcumin 80 µM 0.631682522153614 0.246597093750014 no 831 0.263797175504565 1317 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2898 9056270 58.44 µM 0.630985612669742 0.246834779906213 no 832 0.264024965843381 1235 19154699 SGTC_1779 st039427 55 µM 0.630757748919071 0.246912521126419 no 833 0.264099466638065 1370 1124498 SGTC_3071 9117417 49.47 µM 0.629630520451612 0.247297295010654 no 834 0.264468175126089 1248 45595590 YGL055W OLE1 SGTC_1274 0865-0114 173 µM 0.624709719551011 0.248980733539361 no 835 0.266080796402346 1313 870624 SGTC_2751 anetholtrithion 17.25 µM 0.62445864741024 0.24906679018925 no 836 0.266163209887255 1290 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2196 6573537 42.6665 µM 0.623345828324227 0.249448406773684 no 837 0.266528644083694 1350 2903087 SGTC_375 3970-0961 9.27 µM 0.623244097175019 0.249483308706833 no 838 0.266562063822332 1286 2898222 SGTC_532 1548-0774 215 µM 0.620235657771352 0.250516616412186 no 839 0.267551324378004 1428 5932993 SGTC_406 estrone 100 µM 0.619903506330389 0.250630839204068 no 840 0.267660658587467 1384 5870 A steroid. SGTC_1163 k060-0048 49.9 µM 0.618013591639142 0.251281282291731 no 841 0.268283189634866 1312 6809982 SGTC_110 0850-0284 111.64 µM 0.616845520832796 0.251683737584846 no 842 0.268668311796377 1179 3906265 SGTC_2932 9016711 44.54 µM 0.615170307018194 0.252261521157425 no 843 0.269221127459299 1319 7117328 SGTC_2515 chrysin 20.77 µM 0.615066056735174 0.252297500326643 no 844 0.269255548597325 1335 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1340 1486-1359 257 µM 0.614601085123086 0.252458005656729 no 845 0.269409098813645 1314 4309068 SGTC_1345 1488-0192 31.4 µM 0.614456013838725 0.252508094379742 no 846 0.269457015511174 1322 658348 SGTC_2175 5807670 165.306 µM 0.614138933818505 0.252617590739785 no 847 0.269561761151983 1275 241186 SGTC_907 3448-6986 75.5 µM 0.613323566330235 0.252899274132386 no 848 0.269831206975259 1379 590582 SGTC_2190 6049624 200 µM 0.612733159759915 0.253103343866603 no 849 0.27002639649303 1273 2265554 SGTC_2588 indole-3-carbinol 100 µM 0.612602523176092 0.253148509151582 no 850 0.270069594736031 1335 3712 Induces cell cycle arrest. SGTC_3274 9138298 49.47 µM 0.611940975554403 0.253377292594804 no 851 0.270288405021784 1288 17015756 SGTC_292 k038-0015 474 µM 0.610171319322234 0.253989827747031 no 852 0.270874163273638 1319 46368540 SGTC_725 1497-0963 19 µM 0.603369825773195 0.256351256546472 no 853 0.273131345454463 1365 3549977 SGTC_2080 5212524 12.4 µM 0.603111049868368 0.25644132706534 no 854 0.273217408008722 1329 260183 SGTC_132 0417-1715 25.805 µM 0.602533498853208 0.256642411105958 no 855 0.273409535830154 1383 6769098 SGTC_244 nsc-207895 1.295 µM 0.600900012549952 0.257211580869039 no 856 0.273953292427253 1248 42640 SGTC_101 0490-5701 117.494 µM 0.600770505006165 0.257256734363061 no 857 0.273996425890051 1255 4661669 SGTC_2075 5212009 200 µM 0.600574533811725 0.257325068596543 no 858 0.274061701953695 1325 780898 SGTC_3010 9080089 71.4286 µM 0.600282043597651 0.257427076102186 no 859 0.27415914183731 1384 17027233 SGTC_2222 6885208 172.143 µM 0.597722253022696 0.258320712277265 no 860 0.275012637305347 1311 609514 SGTC_3128 9127691 49.47 µM 0.597463645344326 0.25841108288618 no 861 0.275098936041788 1350 41316314 SGTC_3345 9148410 3.559 µM 0.597205005971163 0.258501480950275 no 862 0.275185258692334 1323 4903596 SGTC_414 piperonyl butoxide 100 µM 0.595672770494462 0.259037354340076 no 863 0.275696926076679 1311 5794 A potent inhibitor of cytochrome P450. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.594242141511948 0.259538210669139 no 864 0.276175085261141 1535 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2218 6965428 192.983 µM 0.593931569816437 0.25964700635247 no 865 0.276278941398439 1346 675684 SGTC_3160 9100216 49.47 µM 0.593721851684778 0.259720485561023 no 866 0.276349082628608 1304 17191039 SGTC_829 1635-0120 117 µM 0.593007854146066 0.259970730229483 no 867 0.276587947988115 1385 285054 SGTC_3067 9117431 49.47 µM 0.592739803903955 0.260064709628163 no 868 0.276677649373158 1337 17150885 SGTC_1656 st012921 11 µM 0.591090052481799 0.260643503946284 no 869 0.277230042320595 1348 6732821 SGTC_1356 1502-0781 85.8 µM 0.590164575683048 0.260968485773082 no 870 0.277540159490749 1327 567702 SGTC_2044 5102272 200 µM 0.58981187849693 0.26109239044857 no 871 0.277658389063772 1350 592666 SGTC_2650 prasterone 100 µM 0.588864379697874 0.261425402236604 no 872 0.277976127144105 1333 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1309 pyrazolanthrone 13.4 µM 0.588570349704156 0.261528787543737 no 873 0.27807476441373 1413 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1303 1160-0052 261 µM 0.588295542988074 0.261625432633685 no 874 0.278166968347799 1374 3562476 SGTC_1185 1319-0113 81.3 µM 0.587148070862088 0.262029178036983 no 875 0.27855213250289 1391 4672763 SGTC_1100 amiodarone 5.07 µM 0.586088547796015 0.26240226140634 no 876 0.278908005907963 1388 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_754 3474-0146 171 µM 0.585309285075696 0.262676831906243 no 877 0.279169886352781 1287 24762078 SGTC_1475 4092-1048 11.7 µM 0.584540688232451 0.26294778823685 no 878 0.279428299435817 1346 2881759 SGTC_2564 betulinic acid 100 µM 0.583545397347565 0.263298874058182 no 879 0.279763102785213 1481 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2938 9059746 27.26 µM 0.581286085048804 0.264096727101225 no 880 0.280523828626501 1375 6471769 SGTC_618 k072-0232 33.2 µM 0.581258079629967 0.264106624651643 no 881 0.280533264519966 1373 5872756 YGL099W LSG1 SGTC_3264 9137442 49.47 µM 0.581201118201027 0.264126756289255 no 882 0.280552457064477 1430 17015726 SGTC_3312 9133330 71.43 µM 0.580625755076953 0.264330148269833 no 883 0.280746355134518 1423 17617324 SGTC_1132 3456-3614 2.5 µM 0.580027537602999 0.264541703827351 no 884 0.280948023845283 1514 3125502 SGTC_1646 st011709 75.6 µM 0.577542117928472 0.265421577170662 no 885 0.281786647603031 1358 5757843 SGTC_2795 7780010 54.55 µM 0.577240737163599 0.265528371045481 no 886 0.281888420669779 1381 953673 SGTC_1830 st055982 50.3 µM 0.576642555247031 0.265740400562702 no 887 0.282090472760959 1360 455313 An antimicrobial agent. SGTC_2347 9049783 174.81 µM 0.572417331949836 0.267240499029188 no 888 0.283519638323488 1421 6467988 YPL169C MEX67 SGTC_2376 9072922 81.32 µM 0.572313636972464 0.267277367940513 no 889 0.283554756330614 1406 17087968 SGTC_1916 st067606 49.2 µM 0.571061371115727 0.267722815586511 no 890 0.283979021218788 1449 19590279 SGTC_18 0111-0177 500 nM 0.567926897191764 0.268839427374907 no 891 0.285042303651893 1417 721752 SGTC_2375 9072683 200 µM 0.567417755438378 0.269021022446824 no 892 0.285215194765652 1470 16798029 SGTC_848 0368-0089 85.6 µM 0.567171295688246 0.269108949105028 no 893 0.285298903943265 1339 762535 SGTC_2516 gossypol 71.55 µM 0.566737731024232 0.269263662056629 no 894 0.285446191037446 1451 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3060 1327-0027 12.5 µM 0.566465200297963 0.2693609345843 no 895 0.285538791507604 1327 16000455 YPR107C YTH1 SGTC_3136 9095672 49.47 µM 0.566184198049717 0.269461249240229 no 896 0.285634285401033 1271 17217380 SGTC_1263 0774-1208 64.8 µM 0.56573866937566 0.269620336360056 no 897 0.285785721977112 1459 906585 SGTC_973 1325-0077 65.9 µM 0.565081259122045 0.26985516699237 no 898 0.286009247476561 1479 2835149 SGTC_251 melphalan 456.522 µM 0.563319626883304 0.27048493631031 no 899 0.286608627828824 1475 460612 A DNA alkylator. SGTC_2750 bromebric acid 70.15 µM 0.563057171848361 0.270578824684303 no 900 0.286697976882483 1441 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1204 4049-0315 18.3 µM 0.562380261274796 0.270821051879453 no 901 0.286928482319187 1508 588402 SGTC_405 ebelactone b 50 µM 0.561963269761091 0.270970322912897 no 902 0.287070522330203 1385 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.55846167485829 0.272225411007543 no 903 0.288264583996437 1285 4000243 SGTC_1 0258-0098 57.368 µM 0.556399130790878 0.272966045062029 no 904 0.288969016487636 1347 6790032 YDR047W HEM12 SGTC_3072 9116419 49.47 µM 0.556140413915614 0.273059017562775 no 905 0.289057434680768 1350 17170162 SGTC_2059 5238311 157 µM 0.555411427309667 0.273321070596123 no 906 0.289306639063304 1383 703021 SGTC_231 b-estradiol 524 µM 0.554794290564929 0.273543013624862 no 907 0.289517686408177 1345 450 A steroid. SGTC_1072 oxiconazole 14.9 nM 0.553840111126836 0.273886343961308 no 908 0.289844137259335 1413 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2597 laccaic acid a 100 µM 0.553136988230381 0.274139476055427 no 909 0.290084805251754 1417 5491415 A textile dye. SGTC_2115 tiliquinol 12.7705 µM 0.552338048793877 0.274427243369967 no 910 0.29035838337124 1426 71208 A bioactive hydroxyquinoline. SGTC_1399 3562-5772 25 µM 0.552313251244594 0.274436177500962 no 911 0.290366876644628 1359 23847490 SGTC_2955 9076254 12.21 µM 0.551509537843446 0.274725819329362 no 912 0.290642215101661 1386 16459619 SGTC_1881 5652484 16 µM 0.551018881801857 0.274902715771542 no 913 0.290810365482207 1440 2255129 SGTC_1829 berberine 14.4 µM 0.54911717508617 0.275588868875789 no 914 0.291462519643127 1494 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.548960601124507 0.275645399688313 no 915 0.291516244088154 1457 676296 Flavone; oxidizing agent. SGTC_129 0088-0017 176.636 µM 0.548221405733089 0.275912362129493 no 916 0.291769942876868 1395 182446 SGTC_2084 5306078 60.6385 µM 0.548103968332223 0.275954786657565 no 917 0.29181025796256 1419 679340 SGTC_3352 9151559 45.5865 µM 0.548013870864359 0.275987336744465 no 918 0.291841189281777 1362 17159339 SGTC_1088 bifonazole 369 nM 0.547313817143856 0.276240313841822 no 919 0.292081576416514 1352 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1219 1469-0211 33.1 µM 0.54671141980536 0.276458092083085 no 920 0.292288503672703 1407 6822282 SGTC_3 0833-0587 95.581 µM 0.546559500768219 0.276513027031726 no 921 0.292340699577072 1350 5382644 SGTC_1921 5740136 50 µM 0.546263790799663 0.276619973096561 no 922 0.292442311182871 1525 1774243 SGTC_1282 0886-0010 32.4 µM 0.54611019756919 0.27667552941369 no 923 0.292495095234737 1478 2836211 YNL267W PIK1 SGTC_1237 0330-0133 46.1 µM 0.546010377466595 0.276711638345513 no 924 0.292529401916526 1390 X1237 YHR072W ERG7 SGTC_1651 st011928 86.1 µM 0.542730819608272 0.277899268322668 no 925 0.29365757557209 1415 720198 SGTC_1608 st001473 40.5 µM 0.542603259898651 0.277945511885036 no 926 0.293701496998495 1377 7292267 SGTC_2161 5662504 8.5105 µM 0.542065698979169 0.278140432318098 no 927 0.293886623652421 1395 2859334 SGTC_1795 st049545 62.3 µM 0.541256190200323 0.278434087207605 no 928 0.294165506216489 1404 5291882 SGTC_2520 obtusaquinone 4.71 µM 0.541254360328533 0.278434751177304 no 929 0.294166136761167 1510 5967872 SGTC_1210 3013-0140 750 nM 0.541002894922007 0.278526002836314 no 930 0.294252793674763 1538 905973 SGTC_2198 6589944 200 µM 0.540784436727472 0.278605288675727 no 931 0.294328085619494 1418 5290268 SGTC_3187 9109394 49.47 µM 0.54035045475496 0.27876282795456 no 932 0.294477684543761 1338 17098090 SGTC_3108 9121785 49.47 µM 0.539813656307119 0.278957750486492 no 933 0.294662774108026 1470 17140271 SGTC_925 2064-1272 59.6 µM 0.539660871914603 0.279013241753139 no 934 0.294715464390079 1406 6815817 SGTC_566 0958-0068 16.5 µM 0.539516246284184 0.279065774704518 no 935 0.29476534498781 1421 6815365 SGTC_1797 st048695 56.8 µM 0.535737682467529 0.280439979394449 no 936 0.296069928265303 1470 592262 YIL048W NEO1 SGTC_897 1000-0139 31.4 µM 0.534481205507387 0.280897665157554 no 937 0.296504324622001 1478 6151020 SGTC_3253 9135987 49.47 µM 0.533578481136836 0.281226715327017 no 938 0.296816599798508 1427 4182430 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.532853938598803 0.281490951380685 no 939 0.297067346221521 1455 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2711 st079103 59.1 µM 0.532162436184512 0.281743249567426 no 940 0.297306748571736 1490 54693780 SGTC_630 4356-0227 183 µM 0.530815210474196 0.282235104579956 no 941 0.297773419311721 1454 779312 SGTC_828 2074-0507 139 µM 0.529960272172668 0.282547445883391 no 942 0.298069737895242 1517 X828 SGTC_3069 9117009 49.47 µM 0.529252026496158 0.282806320614132 no 943 0.298315315043962 1379 41904981 SGTC_1980 st071811 45.7 µM 0.529099167123203 0.28286220802026 no 944 0.298368329595209 1482 4974850 SGTC_898 1000-0849 28.3 µM 0.528796472458562 0.282972892837242 no 945 0.298473322540058 1432 6751807 SGTC_1460 k062-0059 9.15 µM 0.526997702616218 0.283631068417424 no 946 0.299097591930937 1410 1373085 SGTC_2346 9031566 143.75 µM 0.525625361777202 0.284133704949056 no 947 0.299574265873207 1509 4771086 SGTC_1676 st018489 23.4 µM 0.525495862467748 0.284181157634123 no 948 0.299619264412834 1469 3696235 SGTC_2941 9056145 11.23 µM 0.524975044598842 0.284372040201146 no 949 0.299800269605314 1375 2119517 SGTC_1654 st012436 41.8 µM 0.523845948041673 0.28478607046368 no 950 0.300192846068517 1447 4323132 SGTC_2277 7947813 106.88 µM 0.523155900103304 0.285039246812626 no 951 0.300432883749404 1543 1246798 SGTC_3095 9117207 49.47 µM 0.520061964312125 0.286175719107201 no 952 0.301510193796039 1443 17015229 SGTC_718 1130-0073 349 µM 0.518050548679767 0.286915709920577 no 953 0.302211500765068 1521 6740020 SGTC_3221 9128209 49.47 µM 0.517101171253312 0.287265296284032 no 954 0.302542768025557 1481 16460723 SGTC_785 1270-0111 65.3 µM 0.517019741797874 0.287295290188414 no 955 0.302571188868338 1424 6741994 SGTC_790 1575-0012 79.1 µM 0.516427372022499 0.287513529560426 no 956 0.302777976203625 1494 378741 YLR208W SEC13 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.514198563625294 0.28833536303489 no 957 0.303556585953942 1439 521171 SGTC_1384 3089-0840 101 µM 0.512455620382977 0.28897881315204 no 958 0.304166086292052 1546 1069836 SGTC_853 0419-0306 21 µM 0.50918045943504 0.290189742941246 no 959 0.305312869272275 1404 762713 SGTC_2828 7998861 71.43 µM 0.506714390101438 0.291103092231461 no 960 0.306177616104651 1515 2988188 SGTC_24 0417-1663 219 µM 0.505990937236357 0.291371289369335 no 961 0.306431505910096 1463 4329390 SGTC_1859 st055998 20 µM 0.505441687034257 0.291574983373896 no 962 0.306624322811744 1604 676301 SGTC_2177 5811945 192 µM 0.505139334594772 0.291687141618531 no 963 0.306730487926536 1543 5343475 SGTC_3065 9113888 49.47 µM 0.504848783603112 0.291794941035418 no 964 0.306832524473826 1520 16648368 SGTC_946 3434-1334 87.4 µM 0.504369331203104 0.291972866700681 no 965 0.307000932696457 1542 4047976 SGTC_628 1636-0253 16 µM 0.503414289661462 0.292327434823357 no 966 0.307336513508798 1535 4456143 SGTC_3084 9116877 49.47 µM 0.50279851183892 0.292556154237233 no 967 0.307552970018987 1437 27241325 SGTC_1388 3346-4487 254 µM 0.501998827262214 0.292853306507434 no 968 0.307834172956462 1522 3345614 SGTC_2994 9053520 71.4286 µM 0.501165750381997 0.293163015837866 no 969 0.308127238118407 1567 4647384 SGTC_2718 lomofungin 53.02 µM 0.501075421553256 0.293196606114152 no 970 0.308159021933801 1562 5351222 A RNA synthesis inhibitor. SGTC_1398 3558-0053 112 µM 0.500859761529607 0.293276810093412 no 971 0.308234911590866 1447 4532369 SGTC_184 1494-0393 24.714 µM 0.499528148523571 0.293772262173389 no 972 0.308703680861888 1441 3090647 SGTC_2172 5754775 163.918 µM 0.499097411688741 0.293932608906877 no 973 0.308855380446234 1418 2263357 SGTC_3154 9100113 49.47 µM 0.497934805852376 0.294365604200157 no 974 0.309264996982426 1433 25237525 SGTC_2067 5224629 34.075 µM 0.497864370468938 0.294391846273023 no 975 0.309289820840485 1454 2835000 SGTC_2852 9023854 51.95 µM 0.496742340148971 0.294810026072148 no 976 0.309685380342147 1542 19798528 SGTC_886 0866-0150 153 µM 0.496049154331178 0.295068512643827 no 977 0.309929865641402 1597 271463 SGTC_1322 1348-1070 12 µM 0.495656798518974 0.295214867005103 no 978 0.310068286049149 1466 6758089 SGTC_156 3474-0145 5.642 µM 0.495628790226115 0.295225315778961 no 979 0.310078168210191 1541 2265471 SGTC_2041 5107442 45.335 µM 0.492759085336358 0.296296788957773 no 980 0.311091411720837 1565 793005 SGTC_2496 diffractaic acid 79.83 µM 0.492544474262058 0.296376990770517 no 981 0.311167244907114 1613 94870 An apoptosis inducer which activates caspases. SGTC_2371 9071574 200 µM 0.491541490650966 0.296751945351265 no 982 0.311521757098119 1474 45596039 SGTC_493 zm226600 134 µM 0.489565048550818 0.297491451771993 no 983 0.312220857016114 1524 5240098 A potassium channel opener. YCR052W RSC6 SGTC_978 1416-0512 87.4 µM 0.489498174968941 0.297516487930992 no 984 0.312244523145038 1527 6814003 SGTC_1729 st035615 45.989 µM 0.488917512825706 0.297733916890654 no 985 0.312450048288177 1479 17385451 SGTC_621 3584-0052 32.1 µM 0.487870585413123 0.298126121960391 no 986 0.312820755267695 1546 2273927 SGTC_3117 9124945 49.47 µM 0.487086967720125 0.298419838581484 no 987 0.313098350744182 1385 17592065 SGTC_3135 9127742 49.47 µM 0.485714695229876 0.298934512540758 no 988 0.313584731574773 1475 3643468 SGTC_2033 5192550 145 µM 0.482802002699429 0.300028258431353 no 989 0.314618164340934 1476 182073 SGTC_2671 danthron 100 µM 0.481925985358716 0.300357565718689 no 990 0.314929262913942 1495 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2891 9063876 19.48 µM 0.480804277262484 0.300779469920299 no 991 0.315327805006497 1531 6472478 SGTC_1057 3448-5381 134 µM 0.479012719511212 0.301453876322657 no 992 0.315964789971798 1621 5497911 SGTC_3131 9127911 49.47 µM 0.478291275837371 0.301725645592822 no 993 0.316221452445462 1545 45595681 SGTC_1524 corynanthine 62.1 µM 0.477899549625693 0.3018732557671 no 994 0.316360850982866 1563 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2055 5235184 200 µM 0.477602197975165 0.301985325402755 no 995 0.316466683091981 1517 2836034 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.4772971127005 0.302100329203556 no 996 0.316575283341349 1631 5024745 SGTC_1186 1319-0216 26 µM 0.47689661416314 0.302251329472308 no 997 0.316717871557311 1632 4565136 SGTC_1733 st037357 54.9 µM 0.47688841319132 0.302254421844794 no 998 0.316720791607762 1426 1272339 YGL099W LSG1 SGTC_1911 st060208 74.3 µM 0.476071280737209 0.302562612322034 no 999 0.317011798260125 1601 688783 SGTC_1332 1480-0653 17.5 µM 0.475565829229646 0.302753319387446 no 1000 0.317191862182857 1525 5749438 SGTC_1390 3413-2614 145 µM 0.475490028245338 0.30278192377239 no 1001 0.317218869540637 1515 3421432 SGTC_2357 9067248 200 µM 0.474972735137671 0.302977162660697 no 1002 0.31740320342061 1525 9150235 SGTC_2212 7123476 200 µM 0.472587873263564 0.303877994675212 no 1003 0.318253617924205 1548 1085715 SGTC_2505 galangin 7.89 µM 0.47081056086373 0.304550113352921 no 1004 0.318888011093641 1461 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1169 aniline yellow 25.8 µM 0.469520575096607 0.30503835560612 no 1005 0.319348790789768 1591 6051 A DNA damaging agent. SGTC_868 0527-0199 213 µM 0.46936308005442 0.305097989162385 no 1006 0.319405066760185 1537 2849450 SGTC_3326 9140064 16.379 µM 0.468675147878466 0.305358526856816 no 1007 0.319650926752847 1468 1868434 SGTC_418 lividomycin a 100 µM 0.468226863846624 0.305528356690641 no 1008 0.319811181596185 1581 72394 An antibiotic. SGTC_959 1222-0044 107 µM 0.467449735818378 0.305822866337216 no 1009 0.320089072948713 1594 6083612 SGTC_2701 st077767 14.721 µM 0.467073041845861 0.305965667964101 no 1010 0.320223810385674 1490 5721188 SGTC_2549 cedrol 20.94 µM 0.466767554256028 0.306081497492294 no 1011 0.320333095843349 1581 6708665 A sedative which affects the nervous system. SGTC_2965 9082772 38.63 µM 0.466587745735503 0.306149683259947 no 1012 0.320397428022606 1645 16459634 SGTC_1293 1000-1278 195 µM 0.465425480997182 0.306590591341876 no 1013 0.320813395085847 1594 678847 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.46529795739766 0.306638984804967 no 1014 0.320859048671162 1589 756377 SGTC_588 3970-1144 52.9 µM 0.464302954605241 0.307016690484353 no 1015 0.321215353721217 1573 1888707 SGTC_2897 9048598 12.99 µM 0.462962511300522 0.307525850207479 no 1016 0.321695619384101 1509 6467404 SGTC_2160 5660466 132.927 µM 0.462210232686418 0.307811761562025 no 1017 0.321965282948785 1598 2859134 SGTC_3323 9138564 53.9225 µM 0.460919118575182 0.308302735018631 no 1018 0.322428317286091 1655 43912313 YNL103W MET4 SGTC_182 3448-4371 550.524 µM 0.459471075096183 0.308853792406073 no 1019 0.322947959348886 1663 3491403 SGTC_1042 0350-0096 82 µM 0.458808043089814 0.309106255061546 no 1020 0.323186009209252 1499 3122515 SGTC_2781 5567276 71.43 µM 0.457623269714699 0.309557605642317 no 1021 0.323611561323147 1589 2853274 SGTC_1116 jasmonic acid  1.58368 µM 0.457471414723687 0.309615477023513 no 1022 0.323666121962938 1593 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_914 3820-6779 408 µM 0.457068820337918 0.30976892711377 no 1023 0.323810790192592 1484 2893481 SGTC_2860 9025725 38.96 µM 0.456702636447904 0.309908528026359 no 1024 0.323942397799033 1499 40546248 SGTC_689 0833-0039 98 µM 0.456552414866008 0.309965805188603 no 1025 0.323996394261481 1621 5374726 SGTC_1554 st069299 38.7 µM 0.456535286852692 0.309972336127724 no 1026 0.324002551082966 1549 24207999 SGTC_3290 9121031 71.43 µM 0.454793443683054 0.310636816551742 no 1027 0.324628923734632 1514 17014854 SGTC_1383 3049-0032 20.7 µM 0.454185075485749 0.310869043371004 no 1028 0.324847812022228 1651 712864 SGTC_1808 st050063 61.5 µM 0.452029984137405 0.311692292395036 no 1029 0.325623690949834 1608 4011993 SGTC_2759 disulfiram 3.38 µM 0.452026995346983 0.311693434773743 no 1030 0.325624767504 1495 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1659 st012954 42.1 µM 0.45095944953603 0.312101589142437 no 1031 0.32600938757653 1574 24207262 SGTC_1717 st033143 58.0435 µM 0.450319121726758 0.31234651617747 no 1032 0.326240176563681 1666 674616 SGTC_883 0850-0245 24.6 µM 0.450064280082837 0.312444016840751 no 1033 0.326332045920097 1625 6823229 YPR165W RHO1 SGTC_989 1501-0895 10.3 µM 0.449796101058964 0.312546634474626 no 1034 0.326428734725861 1621 2830112 SGTC_3342 9147791 14.508 µM 0.448876320482329 0.312898695222445 no 1035 0.326760439408003 1522 1838168 SGTC_1104 tacrolimus 29.8 µM 0.447262232705969 0.313516925673119 no 1036 0.327342866243606 1557 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1841 st054148 70 µM 0.44615182005638 0.313942542183843 no 1037 0.327743791422489 1504 675442 SGTC_463 ikarugamyin 104 µM 0.445944892383119 0.314021884084457 no 1038 0.327818526624405 1602 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1636 st007707 68.9 µM 0.444646240282009 0.314520020069963 no 1039 0.328287712728425 1656 403051 SGTC_2122 5258151 111.688 µM 0.444090235052931 0.31473339547663 no 1040 0.328488673071439 1530 2173356 SGTC_740 k014-0057 261 µM 0.443829415664397 0.314833510182163 no 1041 0.328582959708326 1684 4012779 SGTC_2705 st078069 42.8 µM 0.443417776156843 0.314991544406172 no 1042 0.328731790271408 1538 1530061 SGTC_180 1486-1293 102.781 µM 0.443361108557577 0.315013302551671 no 1043 0.328752280886353 1723 4140536 SGTC_3249 9135183 49.47 µM 0.443012588485103 0.31514713476399 no 1044 0.328878314670188 1597 4902779 SGTC_88 0180-0332 8.668 µM 0.442686094687643 0.315272530870374 no 1045 0.328996400844066 1602 3101745 SGTC_2406 ethylparaben 405.7 µM 0.442086457696869 0.315502888211485 no 1046 0.329213321816051 1385 8434 A possible steroid mimic. SGTC_3042 9091578 49.47 µM 0.441573169460882 0.31570013067629 no 1047 0.329399051483703 1566 25236497 SGTC_2066 5222451 176 µM 0.440965486222554 0.315933714402248 no 1048 0.329618991729879 1513 2281147 SGTC_990 3985-0011 41.3 µM 0.43968305674092 0.316426900985382 no 1049 0.330083337871963 1567 5399565 YGL099W LSG1 SGTC_2946 9065502 71.43 µM 0.439613137694007 0.316453799296825 no 1050 0.330108661917024 1500 16489101 SGTC_1483 3453-0561 55.9 µM 0.438581535226182 0.316850776246924 no 1051 0.33048238939444 1605 4546991 SGTC_2820 7989630 71.43 µM 0.438409183048777 0.316917120670966 no 1052 0.330544845394034 1620 2984098 SGTC_1674 st016616 23.6 µM 0.438259880532755 0.316974597227497 no 1053 0.330598952603655 1513 625830 SGTC_1344 1488-0097 29.1 µM 0.437406819686511 0.317303082265143 no 1054 0.330908169604353 1580 747966 SGTC_2978 9011784 42.97 µM 0.43585534312777 0.317900872586812 no 1055 0.331470843598963 1753 2994934 SGTC_3306 9127676 59.7925 µM 0.434927354729152 0.318258657419049 no 1056 0.331807579132589 1554 41905287 SGTC_1054 3429-0080 167 µM 0.434683424924852 0.318352732433415 no 1057 0.331896115561894 1646 1162877 SGTC_1011 4112-3381 17.4 µM 0.434321847156527 0.318492201618296 no 1058 0.332027370606686 1616 2877139 SGTC_1156 4092-0367 4.88 µM 0.433352175473436 0.318866354110704 no 1059 0.332379469365817 1599 1357585 SGTC_1459 k035-0031 35.7 µM 0.433091220980799 0.318967076212666 no 1060 0.33247425017737 1470 3877128 YMR208W ERG12 SGTC_3075 9116269 49.47 µM 0.430974381073232 0.319784618620855 no 1061 0.333243499235898 1589 17015205 YNL244C SUI1 SGTC_2195 6536160 144.242 µM 0.430043157685319 0.320144543161385 no 1062 0.333582123704002 1510 3834386 SGTC_130 0136-0219 337.655 µM 0.429740213963684 0.32026166960617 no 1063 0.333692313586703 1663 234244 SGTC_2307 7538926 6.34 µM 0.42945644606932 0.320371398390152 no 1064 0.333795541648439 1576 96582 SGTC_1712 st032288 53.4 µM 0.429442449033446 0.320376811240302 no 1065 0.333800633765332 1559 2883011 SGTC_1333 1482-0047 286 µM 0.429216296552888 0.320464272873384 no 1066 0.333882912202817 1651 3811116 SGTC_3028 9087778 49.47 µM 0.42820164421908 0.320856799600624 no 1067 0.334252159663958 1510 17217395 SGTC_3058 9093861 49.47 µM 0.427850951798389 0.320992514501828 no 1068 0.334379819315684 1605 17217477 SGTC_1807 st050092 58.9 µM 0.425107892331561 0.322054878575874 no 1069 0.335379012394207 1555 5008496 SGTC_384 k007-0144 5.16 µM 0.425086503371418 0.3220631680725 no 1070 0.3353868081742 1608 6824886 SGTC_1735 st034310 56.75 µM 0.424714195624396 0.322207473688859 no 1071 0.335522517067038 1675 871153 SGTC_1990 st072050 59.8 µM 0.424516694208245 0.322284035660171 no 1072 0.335594516488385 1551 17233948 SGTC_220 paclitaxel 373.376 µM 0.424031862916871 0.322472013821851 no 1073 0.335771288017819 1621 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2112 5488546 200 µM 0.42386303891001 0.32253748070579 no 1074 0.335832850494371 1561 600757 SGTC_2337 9009472 200 µM 0.423473594758784 0.322688521060179 no 1075 0.335974879955594 1687 5742383 SGTC_1539 benzyladenosine 56 µM 0.422265882165984 0.323157101125156 no 1076 0.336415479076592 1561 92208 A nucleotide analog. SGTC_2472 5377652 49.4 µM 0.421954909593783 0.323277800765427 no 1077 0.336528964861541 1563 1610903 SGTC_2081 5214970 32.255 µM 0.421684093304379 0.323382929464351 no 1078 0.336627808215178 1677 2063512 SGTC_1836 st055642 81 µM 0.420627508015231 0.323793222128332 no 1079 0.337013551809809 1517 8571 SGTC_2207 7258803 200 µM 0.420374964738703 0.323891321345212 no 1080 0.33710577701293 1647 3666799 SGTC_596 1155-0152 116 µM 0.420226501207345 0.323948996997759 no 1081 0.337159998347675 1576 280313 SGTC_2787 5284540 71.43 µM 0.419733916352684 0.32414038842391 no 1082 0.337339922702229 1591 736958 SGTC_4 0960-0234 25.671 µM 0.418134196695543 0.324762272051937 no 1083 0.337924501851634 1590 6821112 SGTC_1165 k072-0275 30.3 µM 0.41800821816116 0.324811266407764 no 1084 0.337970554313842 1610 6153523 YGL055W OLE1 SGTC_1415 3966-0071 78.1 µM 0.417825052986098 0.324882506646516 no 1085 0.338037516136788 1610 2893185 SGTC_820 1582-0060 59.9 µM 0.41776128427551 0.324907310343449 no 1086 0.338060830008623 1571 3848840 SGTC_2478 5763493 32.33 µM 0.416307708798433 0.325472908373033 no 1087 0.338592426196025 1661 1365576 YLR208W SEC13 SGTC_126 0417-1624 672.48 µM 0.416100397761167 0.325553607579329 no 1088 0.338668269454285 1672 41912 YDL195W SEC31 SGTC_703 3875-0075 71.8 µM 0.415780445899424 0.325678170114521 no 1089 0.338785334391345 1662 2850814 SGTC_2252 omeprazole 400 µM 0.414011731289493 0.326367110806799 no 1090 0.339432757690331 1682 4594 A proton pump inhibitor. SGTC_2394 5221648 200 µM 0.413745030242849 0.326471046327954 no 1091 0.339530422583637 1751 788586 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.412541607239658 0.32694019731603 no 1092 0.339971245389355 1679 5282309 SGTC_1295 1013-0063 9.78 µM 0.412278076107332 0.327042970720278 no 1093 0.340067808040842 1716 6826038 SGTC_3218 9131285 49.47 µM 0.412181315105223 0.327080709431788 no 1094 0.340103265684504 1735 17156417 SGTC_189 3970-0742 2.116 µM 0.41202385828001 0.327142124498757 no 1095 0.340160968068515 1686 2891807 SGTC_3314 9135860 59.4275 µM 0.411920571696567 0.327182413338229 no 1096 0.340198820999041 1713 25252478 SGTC_822 1487-0950 154 µM 0.407656313213193 0.328847519176445 no 1097 0.341763007463059 1681 1958375 SGTC_2959 9079155 11 µM 0.406850947620771 0.329162381015401 no 1098 0.34205873247562 1626 16189457 SGTC_1716 st033144 30.6155 µM 0.406159978155457 0.329432615727762 no 1099 0.342312529222659 1732 674617 SGTC_634 1611-4317 11.2 µM 0.405910973205583 0.329530022172039 no 1100 0.342404007527277 1686 2843522 SGTC_1782 st039423 80.636 µM 0.403949483210987 0.330297727241579 no 1101 0.343124933711738 1559 2068169 SGTC_1226 3909-7979 35.4 µM 0.402600903800498 0.330825960964971 no 1102 0.343620922335924 1728 6615510 SGTC_293 4049-0273 38.5 µM 0.402432834898393 0.33089181659185 no 1103 0.343682754617127 1619 1380311 SGTC_3017 9080681 49.47 µM 0.402421116751316 0.330896408391505 no 1104 0.343687065860741 1597 16451914 SGTC_2743 auranofin 4.32 µM 0.401759527532902 0.331155695842357 no 1105 0.343930505247196 1658 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1271 0832-2808 169 µM 0.401149890734443 0.331394694003764 no 1106 0.344154885434872 1749 3663794 SGTC_2890 9046729 58.44 µM 0.401072825689941 0.331424910988885 no 1107 0.344183253558428 1557 903329 SGTC_788 1182-0090 188 µM 0.401008953651262 0.331449955865549 no 1108 0.344206765918781 1784 5715185 SGTC_49 0717-0965 32.132 µM 0.399328266507127 0.332109240959809 no 1109 0.344825670996316 1694 5889349 YGL099W LSG1 SGTC_59 0330-0160 1.33 µM 0.398622507530057 0.332386245009711 no 1110 0.345085687357476 1684 4293482 SGTC_3281 9140613 49.47 µM 0.397564177607157 0.332801801577012 no 1111 0.345475735304643 1539 16013766 SGTC_1973 st070275 50.2 µM 0.397437923319282 0.33285138944779 no 1112 0.345522277342988 1643 17118334 SGTC_1875 nocodazole 6 µM 0.395971668720814 0.333427492302515 no 1113 0.346062964357426 1704 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_715 0868-0130 184 µM 0.395071413886328 0.333781404316426 no 1114 0.34639509243361 1795 2876258 SGTC_1711 st032263 62.8 µM 0.394748363214305 0.333908439454392 no 1115 0.346514303279957 1660 3958979 SGTC_131 0141-0277 33.849 µM 0.394167613771714 0.334136858877634 no 1116 0.346728647304259 1730 1547771 SGTC_2853 9015042 58.44 µM 0.393841159882552 0.334265286173008 no 1117 0.346849157028128 1549 6457456 SGTC_2570 licareol 100 µM 0.393748985567776 0.334301551156516 no 1118 0.346883185776135 1603 443158 SGTC_2740 felodipine 17.08 µM 0.393630056982941 0.334348344602245 no 1119 0.346927093442279 1741 3333 L-type calcium channel blocker SGTC_2914 7968218 45.32 µM 0.391891103162517 0.335032844180678 no 1120 0.347569338462528 1729 2977111 SGTC_1232 0279-0259 161 µM 0.39147363616697 0.335197252257556 no 1121 0.347723586109785 1608 1560000 SGTC_1507 4075-3230 155 µM 0.3899955695033 0.335779602433234 no 1122 0.348269911542717 1679 659771 SGTC_1978 st071761 42 µM 0.389802675028307 0.335855630936243 no 1123 0.348341232775665 1594 5147680 SGTC_2847 9005661 71.43 µM 0.389660693060167 0.335911596792635 no 1124 0.348393732931502 1639 2991449 SGTC_692 k241-0027 77.8 µM 0.389358823692735 0.336030598483885 no 1125 0.348505363720978 1712 3600480 SGTC_1297 1068-0111 14.1 µM 0.389119820276239 0.336124829080182 no 1126 0.348593756093893 1585 767057 SGTC_1015 4130-4525 82 µM 0.388921687232918 0.336202953741447 no 1127 0.348667039311881 1597 1363237 SGTC_649 1123-0311 367 µM 0.388394554594677 0.33641083871727 no 1128 0.348862036685886 1704 693629 YIL048W NEO1 SGTC_475 α-linolenic acid 10 µM 0.386875671246453 0.337010119339697 no 1129 0.349424126472203 1729 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_816 0325-0417 81.3 µM 0.386550836252752 0.337138337878249 no 1130 0.349544380359404 1623 68101 SGTC_3183 9108214 49.47 µM 0.38560711004054 0.337510951822024 no 1131 0.349893833348327 1642 4974831 SGTC_400 oxethazaine 37.5 µM 0.38546489093572 0.337567118398988 no 1132 0.349946506787203 1624 4621 A local anesthetic. SGTC_361 000s-0510 1.45 µM 0.385171164874321 0.337683131056541 no 1133 0.350055302729803 1645 660 SGTC_1004 4084-0029 199 µM 0.385111562916228 0.337706673858954 no 1134 0.350077380758977 1772 716894 YLR208W SEC13 SGTC_3339 9145883 14.936 µM 0.384982542826296 0.337757639032402 no 1135 0.350125174704935 1727 2030670 SGTC_1022 4477-0945 21.3 µM 0.382541293486911 0.338722534665144 no 1136 0.351029952932919 1626 4648966 SGTC_152 4469-0003 551.229 µM 0.380112899550796 0.339683400494719 no 1137 0.351930805368517 1697 697280 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.379125143622695 0.340074534029088 no 1138 0.352297467852275 1801 1273210 SGTC_2916 7875993 68.79 µM 0.37901361717538 0.340118707316309 no 1139 0.352338875948687 1813 1299250 SGTC_1760 st045453 10.4495 µM 0.377603814753748 0.340677289530156 no 1140 0.352862465197489 1749 3323419 YIL048W NEO1 SGTC_963 1269-2853 151 µM 0.375804087128842 0.341390873105063 no 1141 0.353531274539906 1598 3668223 SGTC_270 tamoxifen 5.46 µM 0.374851040253138 0.341768981700234 no 1142 0.353885626314833 1793 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1872 amphotericin b 148 nM 0.374536729960157 0.341893714942459 no 1143 0.354002517609986 1745 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_967 1306-0166 352 µM 0.373823548965516 0.3421768030069 no 1144 0.354267799049363 1797 4437607 SGTC_185 k048-0037 25.491 µM 0.372262137396612 0.342796894913095 no 1145 0.354848843023458 1791 6827589 SGTC_3086 9117350 49.47 µM 0.371834766821763 0.342966692862121 no 1146 0.355007938249445 1629 2679265 SGTC_2322 7413319 38.22 µM 0.370372291211437 0.343547986622663 no 1147 0.355552558289652 1685 1840400 SGTC_583 1488-1091 88.9 µM 0.370332051444496 0.34356398606053 no 1148 0.355567547592982 1799 4303273 SGTC_688 0527-0193 473 µM 0.368695146503623 0.344215061102754 no 1149 0.356177483405995 1713 4007154 SGTC_2460 5552655 174.22 µM 0.368350591837282 0.344352165825108 no 1150 0.356305916701826 1621 5401989 SGTC_415 dibenzyl ketone 100 µM 0.368013282573065 0.344486407283037 no 1151 0.356431665053477 1781 7593 SGTC_513 4245-1575 41.7 µM 0.367366379427692 0.344743914903755 no 1152 0.356672873173905 1770 719745 SGTC_2188 6126565 140.678 µM 0.366841730533766 0.344952810584482 no 1153 0.356868538959587 1734 874518 SGTC_1794 st048918 76.9 µM 0.366531652702244 0.345076294274208 no 1154 0.356984199003663 1792 672303 SGTC_2960 9079389 5.97 µM 0.365935206717377 0.345313866023937 no 1155 0.357206712259234 1798 16457355 SGTC_2541 muurolladie-3-one 83.07 µM 0.36514730905901 0.345627788767328 no 1156 0.357500723924706 1700 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1434 4073-0095 163 µM 0.364531747865957 0.345873121244833 no 1157 0.357730485438195 1720 24133745 SGTC_1120 ficusin 1.78878 µM 0.360672106919534 0.347412856260944 no 1158 0.359172289296356 1779 6199 A DNA cross-linker. SGTC_3162 9099653 49.47 µM 0.36018765206183 0.347606299512486 no 1159 0.359353404056321 1746 25237511 SGTC_2397 5161689 200 µM 0.359391360308141 0.347924345723063 no 1160 0.359651168537627 1745 2259942 SGTC_3245 9134821 49.47 µM 0.358051822517511 0.348459610729819 no 1161 0.360152266047512 1601 17014901 SGTC_2199 6590217 200 µM 0.357420161406706 0.348712120582607 no 1162 0.360388642805817 1750 703109 SGTC_218 alverine citrate 93.75 µM 0.357375248253613 0.348730077405787 no 1163 0.360405451993129 1754 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1051 3253-3903 78 µM 0.357134148085007 0.348826477967968 no 1164 0.360495690702865 1653 5509239 SGTC_1943 st076331 65.2 µM 0.356766275114085 0.348973585683863 no 1165 0.360633392771166 1735 24208415 SGTC_2913 7966556 36.57 µM 0.356459060216837 0.349096454405344 no 1166 0.360748403182745 1789 2976516 SGTC_2428 5615643 7.78 µM 0.356243414896076 0.349182709885236 no 1167 0.360829140701803 1742 2253075 SGTC_1396 3511-0007 98.6 µM 0.354220523546689 0.349992220391647 no 1168 0.361586811940776 1687 X1396 SGTC_940 3232-1287 54.8 µM 0.352716946556713 0.350594356527083 no 1169 0.362150326696691 1778 1585493 YIL048W NEO1 SGTC_605 1315-0399 119 µM 0.352575472571233 0.350651031842255 no 1170 0.362203364113579 1755 24020461 SGTC_1686 st019653 115.5 µM 0.352124122989161 0.350831867368246 no 1171 0.362372588985774 1802 97252 SGTC_1609 st001574 46.4 µM 0.35180095488836 0.350961367091299 no 1172 0.362493771194762 1665 3960012 SGTC_537 1334-0398 209 µM 0.351763857708316 0.350976233758569 no 1173 0.362507682849973 1824 5846986 SGTC_1959 st077091 55.8 µM 0.350552794739823 0.351461691506046 no 1174 0.362961938010378 1683 821356 YKL052C ASK1 SGTC_449 xestospongin c 11.1929 µM 0.35017871958507 0.351611689541592 no 1175 0.363102288123043 1758 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1583 clindamycin 39.6 µM 0.350010847574164 0.351679010992566 no 1176 0.363165278384616 1624 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2139 5578692 56.4705 µM 0.349457379890158 0.351901000214562 no 1177 0.363372981108658 1810 650991 YMR113W FOL3 SGTC_500 h-89 112 µM 0.349437867973394 0.351908827131215 no 1178 0.363380304181601 1839 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_757 1066-0008 322 µM 0.347573676054414 0.352656909107851 no 1179 0.364080189264158 1765 6842497 SGTC_2455 5377712 9.75 µM 0.346660158648329 0.353023703045065 no 1180 0.364423322491265 1622 2243908 SGTC_3127 9126946 49.47 µM 0.346452359881454 0.353107157132989 no 1181 0.364501390549619 1636 27243249 SGTC_2228 7354201 200 µM 0.345895734706756 0.353330738239343 no 1182 0.364710537119489 1795 753451 SGTC_276 colchicine 750 µM 0.345291933533597 0.353573325898793 no 1183 0.364937455152578 1723 2833 A microtubule depolymerizer. SGTC_2331 7980721 200 µM 0.344261879972753 0.353987305145637 no 1184 0.365324674743618 1807 2981221 SGTC_2063 5246145 200 µM 0.342638144480423 0.3546402360506 no 1185 0.365935351053495 1753 711240 SGTC_1414 3917-0015 5.4 µM 0.341967759360386 0.354909933741953 no 1186 0.366187577718638 1765 6618702 SGTC_2657 nystatin 74.44 µM 0.340707619008177 0.355417088246513 no 1187 0.36666185118268 1766 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_42 0133-0086 60.653 µM 0.339523584062957 0.355893846894795 no 1188 0.367107666791542 1624 162923 Model of phenazepam hydroxylation. SGTC_2333 9017922 200 µM 0.338375519803958 0.356356337043682 no 1189 0.367540109810171 1848 3163164 SGTC_1034 k072-0165 12.7 µM 0.338008081297701 0.356504401912322 no 1190 0.367678548920116 1860 5835461 SGTC_2285 7945142 200 µM 0.337551512756561 0.356688413203276 no 1191 0.367850593339742 1705 2970608 SGTC_686 1319-0111 510 µM 0.337031800381743 0.35689791401442 no 1192 0.368046463924485 1814 4562600 SGTC_684 1140-0066 328 µM 0.336843488623103 0.356973834863536 no 1193 0.368117443832931 1708 6813534 SGTC_2363 9053361 176 µM 0.336380134802187 0.357160667359724 no 1194 0.36829211386399 1839 6469797 YMR079W SEC14 SGTC_2291 7917025 104.35 µM 0.336033010708417 0.357300656409922 no 1195 0.368422986730525 1664 2964612 SGTC_2651 TUB2.036 5 µM 0.335077403658593 0.357686135121181 no 1196 0.368783348909094 1812 15992207 YFL037W TUB2 SGTC_611 3453-1652 23.7 µM 0.334464381705698 0.357933496205402 no 1197 0.369014582039728 1817 1560575 SGTC_782 0083-0095 30.5 µM 0.33378660996201 0.358207053986749 no 1198 0.369270294112643 1717 3591729 An indicator and reagent. SGTC_2373 9071805 200 µM 0.332389472045874 0.358771187203728 no 1199 0.369797593587389 1891 10149009 SGTC_1874 staurosporine 7.6 µM 0.330455682441914 0.35955251679884 no 1200 0.370527836873899 1803 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_208 k072-0098 12.366 µM 0.329376927991786 0.359988632940753 no 1201 0.370935402272437 1750 5948901 SGTC_683 panaxydol 45 µM 0.328494480203673 0.360345522321001 no 1202 0.371268908558049 1814 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.328459566613388 0.360359644969873 no 1203 0.371282105551689 1761 6708630 An antioxidant. SGTC_517 1365-0151 113 µM 0.328391852921275 0.360387035898462 no 1204 0.371307701092508 1755 768657 SGTC_1958 st076513 41.9 µM 0.327487610873459 0.360752880313256 no 1205 0.37164955595868 1704 732122 YGL099W LSG1 SGTC_1035 k081-0041 55.2 µM 0.326779194870175 0.361039585160076 no 1206 0.371917448199426 1860 731709 SGTC_264 promethazine 12.5 mM 0.326753250272024 0.361050086747817 no 1207 0.371927260500487 1830 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_699 0375-0592 111 µM 0.325447728299095 0.361578657593507 no 1208 0.372421118911053 1870 762578 SGTC_196 k015-0023 18.111 µM 0.324876494820816 0.361810017884633 no 1209 0.372637273593748 1730 5211998 SGTC_2608 thymoquinone 42.66 µM 0.324726834774004 0.361870641370351 no 1210 0.372693911573055 1754 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2902 5787006 60.46 µM 0.324697910583362 0.361882358225457 no 1211 0.372704858083184 1709 591003 SGTC_2281 7943571 200 µM 0.324489179010908 0.361966916808989 no 1212 0.37278385667796 1911 1244024 SGTC_1061 3448-9325 110 µM 0.323620046701256 0.362319080636234 no 1213 0.373112854493587 1830 723482 SGTC_2024 5144227 134 µM 0.323538995266787 0.362351927822769 no 1214 0.373143540095758 1805 3475211 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.321961511372016 0.362991425973844 no 1215 0.37374092634983 1823 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_107 0358-0022 2.6945 µM 0.319455400986099 0.364008166541497 no 1216 0.374690602904851 1835 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_117 lucigenin 22.078 µM 0.318717241726699 0.364307824145 no 1217 0.374970469489475 1657 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1889 st059080 5.18 µM 0.318395673851777 0.364438391384019 no 1218 0.375092409718107 1881 176925 Isolated from Daphnopsis sellowiana. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.318292492938648 0.364480289596437 no 1219 0.375131539109174 1713 6708760 SGTC_1752 st044819 83.042 µM 0.317247094957205 0.364904880911251 no 1220 0.37552805873609 1702 441209 YML126C ERG13 SGTC_2954 9074818 52.69 µM 0.315408134194237 0.365652181863697 no 1221 0.37622589580398 1810 16648742 SGTC_2364 9055074 200 µM 0.314968750604175 0.365830810380188 no 1222 0.376392690283914 1697 6470630 SGTC_3230 9131665 49.47 µM 0.312139647102003 0.36698165903416 no 1223 0.377467198330836 1780 15943720 SGTC_1074 carmofur 3.8 µM 0.311272789695476 0.367334527175715 no 1224 0.377796625584237 1777 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3257 9139206 32.98 µM 0.31046159123827 0.367664839967634 no 1225 0.378104981586792 1844 4910041 SGTC_2076 5212012 200 µM 0.310451644929766 0.367668890624044 no 1226 0.378108762899734 1769 604802 SGTC_2411 st077133 39.94 µM 0.309478657226717 0.368065213133079 no 1227 0.378478722450579 1912 1403142 YNL221C POP1 SGTC_1108 betulinic acid 729.144 nM 0.308911919246521 0.368296124618628 no 1228 0.378694264857151 1754 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3265 9137266 49.47 µM 0.308552261215393 0.368442688221375 no 1229 0.378831069969658 1943 17224265 SGTC_1635 st007035 42.4 µM 0.308378035871039 0.36851369336484 no 1230 0.378897346486269 1743 3716403 SGTC_2107 5363541 170.161 µM 0.306636535998338 0.369223684064822 no 1231 0.379560020379412 1802 244052 SGTC_1437 4092-1038 11.6 µM 0.305679327514359 0.369614117879873 no 1232 0.379924407314649 1768 3977136 SGTC_1430 4049-0248 69.1 µM 0.305600331934299 0.36964634523823 no 1233 0.379954483856159 1887 22774488 SGTC_1419 3993-2473 62.6 µM 0.305330253966906 0.369756534261146 no 1234 0.380057318019587 1798 704026 SGTC_2971 9092186 9.93 µM 0.30379580445564 0.370382776583221 no 1235 0.380641731665282 1639 25236400 SGTC_1597 7-benzyloxygramine 47.5 µM 0.303360686424208 0.370560420363386 no 1236 0.380807501272333 1739 260807 SGTC_1563 conessine 56.1 µM 0.303030646021966 0.370695182959654 no 1237 0.380933253400756 1903 441082 An anti-amoebic, histamine inhibitor. SGTC_3133 9127736 49.47 µM 0.30241416550429 0.370946947700986 no 1238 0.381168178736999 1955 27243420 SGTC_310 1273-0058 1.06 µM 0.301953676545598 0.371135043041072 no 1239 0.381343688167468 1812 2734232 SGTC_2861 9024595 19.48 µM 0.301523191300436 0.371310910648443 no 1240 0.381507784142141 1865 16482810 SGTC_826 1683-5028 118 µM 0.3011551727583 0.371461279828754 no 1241 0.381648085425385 1777 722377 SGTC_1981 st071826 47 µM 0.298057097786512 0.372727902026453 no 1242 0.382829792570824 1772 11838600 SGTC_1854 st056233 32.9 µM 0.297257090784735 0.373055202554776 no 1243 0.383135119178791 1923 5393174 SGTC_2093 5331342 194.4 µM 0.296628570402385 0.373312408415023 no 1244 0.383375048020649 1898 33839 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.295111024375037 0.373933657765275 no 1245 0.383954534171614 1811 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2077 5212015 200 µM 0.294989950863044 0.373983236681836 no 1246 0.384000778182877 1776 780900 SGTC_51 1013-0126 23.419 µM 0.29475906863625 0.374077787422221 no 1247 0.384088968195083 1946 1627850 SGTC_453 enantio-paf c16 10 µM 0.294669267060868 0.374114564952067 no 1248 0.384123271296298 1807 13871343 A lipid and platelet activating factor SGTC_450 aminopyrene 156 nM 0.293991802600009 0.374392052106176 no 1249 0.384382083654271 1871 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1557 sumaresinolic acid 42.3 µM 0.292992841495042 0.374801341889847 no 1250 0.38476381168789 1747 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3206 9114350 49.47 µM 0.292921530128216 0.374830564657211 no 1251 0.384791065822747 1817 17087243 SGTC_2545 solidagenone 89.61 µM 0.292388698573654 0.375048937052599 no 1252 0.384994724061658 1802 6708572 An anti ulcer agent SGTC_746 1095-0025 46.6 µM 0.291991714218968 0.375211660715956 no 1253 0.385146479576892 1857 6749286 SGTC_1887 st057648 70.8 µM 0.290506085358349 0.375820816015415 no 1254 0.385714547990852 1924 688672 SGTC_253 dyclonine 31.25 µM 0.290423553264967 0.375854665902285 no 1255 0.385746113460463 1856 3180 An oral anasthetic. SGTC_1081 sertraline 6 µM 0.289373570891343 0.376285391196413 no 1256 0.386147758813375 1903 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_913 3487-1245 167 µM 0.288579920283113 0.3766110660092 no 1257 0.386451431668465 1710 4016153 SGTC_2335 9018011 154.17 µM 0.287987182552463 0.376854353464455 no 1258 0.386678275037726 1907 6458208 SGTC_812 4251-0442 148 µM 0.287866880765254 0.376903736952015 no 1259 0.386724319797299 1915 5723007 SGTC_3269 9137823 49.47 µM 0.286598197826422 0.377424649582006 no 1260 0.387209997249393 1765 17682936 SGTC_12 0849-0099 9.267 µM 0.285039645748804 0.378064885798982 no 1261 0.387806884156248 1903 6071388 SGTC_1714 st033236 13.627 µM 0.284289690357375 0.378373078802582 no 1262 0.388094193125699 1879 2916566 SGTC_1878 temozolomide 1 mM 0.281593764504101 0.379481603193808 no 1263 0.389127511005646 1972 5394 DNA alkylating agent. SGTC_525 k781-2675 26.7 µM 0.281517300143726 0.379513058696462 no 1264 0.389156830407099 1835 3651118 YDL195W SEC31 SGTC_1128 3448-9350 235 µM 0.28112164706349 0.379675833095155 no 1265 0.389308549221887 1761 619386 SGTC_2721 ifenprodil 61.44 µM 0.279310038225661 0.380421413383827 no 1266 0.390003451668889 1899 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2257 7960413 200 µM 0.279085228892992 0.380513966291662 no 1267 0.390089709292194 1873 2974689 YIL048W NEO1 SGTC_2747 doxorubicin 7.63 µM 0.27907245341975 0.380519226097241 no 1268 0.390094611306222 1920 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_971 1315-0384 26.7 µM 0.278809317707021 0.380627566931979 no 1269 0.390195581702971 1752 6769120 SGTC_391 gliotoxin 8.33 µM 0.278590971634529 0.380717473641663 no 1270 0.390279371049711 1855 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_502 l-744,832 89.3 µM 0.277846380289985 0.381024116797538 no 1271 0.390565143014457 1932 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_599 1935-0052 86.5 µM 0.277577550894887 0.381134846493512 no 1272 0.390668333479474 1826 9557311 SGTC_109 0132-0036 33.701 µM 0.277209035747813 0.381286652145454 no 1273 0.390809800943927 1927 67274 A color developer. SGTC_729 4092-0585 94.1 µM 0.276487552278735 0.38158391198378 no 1274 0.391086809508263 1760 2169061 SGTC_1852 st056254 31.4 µM 0.27307584709497 0.382990518858873 no 1275 0.392397456297205 1855 442583 SGTC_2772 vinpocetine 57.06 µM 0.272193895111829 0.383354389502638 no 1276 0.392736467842584 1896 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2540 epiandrosterone 100 µM 0.271880214816027 0.383483830731762 no 1277 0.392857062343356 1863 441302 A steroid. SGTC_2238 6671620 73.2395 µM 0.271780719201195 0.383524890649452 no 1278 0.392895315616774 1731 729941 SGTC_1426 4048-4480 71.7 µM 0.270320569903217 0.384127616282355 no 1279 0.393456820868349 1903 14224343 SGTC_2812 7970281 58.44 µM 0.264323437277117 0.386606059524143 no 1280 0.3957653509827 1924 2233435 SGTC_278 4092-0821 23.9 µM 0.263549127729623 0.386926399294525 no 1281 0.396063681499523 1902 877900 SGTC_2098 5376439 882.5 nM 0.261766571090157 0.387664153688171 no 1282 0.396750706510531 1934 2844116 SGTC_1769 st044406 64.4 µM 0.261085704304234 0.387946054196348 no 1283 0.397013207882271 1820 670903 SGTC_1873 rapamycin 2 nM 0.260981947867427 0.387989017851359 no 1284 0.397053214238047 1810 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2630 antimycin a 100 µM 0.260977243527179 0.387990965865664 no 1285 0.397055028160918 1802 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2158 5657123 3.6195 µM 0.260976726782106 0.387991179844149 no 1286 0.397055227410184 1937 2858827 SGTC_827 3253-0474 693 µM 0.260578618817805 0.388156042101135 no 1287 0.39720873994119 1962 5402065 SGTC_529 4076-0302 30.3 µM 0.259563956730633 0.388576319415607 no 1288 0.397600070963597 1822 5816522 SGTC_1492 4158-0558 28.5 µM 0.259276491436508 0.388695412491421 no 1289 0.397710958241852 1942 3967268 SGTC_2310 7668677 200 µM 0.257810218818676 0.389303032429521 no 1290 0.398276688775255 1879 2197143 SGTC_1791 st048313 56.1 µM 0.257437124095127 0.389457685281789 no 1291 0.398420673731165 1969 1204976 SGTC_364 0083-0097 67.7 µM 0.255444448565272 0.390283972387807 no 1292 0.399189922086239 1836 5207356 SGTC_1032 k061-1018 98.7 µM 0.25541837993046 0.390294785357816 no 1293 0.399199988169938 1986 4005393 SGTC_2372 9071633 200 µM 0.254955290408225 0.390486883704507 no 1294 0.399378815675649 1987 21321366 SGTC_2770 toltrazuril 17.5 µM 0.254566526369015 0.390648171072515 no 1295 0.399528957820429 1966 68591 Kills coccidiodes. SGTC_3195 9113082 49.47 µM 0.250260424558666 0.392435905317347 no 1296 0.4011929797225 2017 17018038 SGTC_2168 5727979 200 µM 0.249922213105286 0.392576414937521 no 1297 0.401323752321595 1887 695210 SGTC_2534 helenine 20.12 µM 0.249394875786943 0.392795524646546 no 1298 0.401527674242122 1837 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1223 0764-0573 147 µM 0.249294678502998 0.392837160661394 no 1299 0.401566423675741 1863 1609797 SGTC_2886 9058944 51.95 µM 0.247467845036478 0.393596498214428 no 1300 0.402273086832131 1883 4949929 SGTC_473 2-arachidonoylglycerol 10 µM 0.246333077977907 0.394068377004507 no 1301 0.402712203076502 1807 5282280 An endocannabinoid. SGTC_1140 3229-1848 2.98 µM 0.24437719174414 0.394882072760857 no 1302 0.403469352355467 1983 2849525 SGTC_2366 9070441 60.58 µM 0.24377664907861 0.39513200517697 no 1303 0.403701903079736 1826 6837235 SGTC_2144 5628481 200 µM 0.243125816927611 0.395402915671788 no 1304 0.403953966059293 1865 2818399 SGTC_263 alizarin 107.927 µM 0.242297352265294 0.395747839260885 no 1305 0.404274882624087 1903 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2616 abietic acid 100 µM 0.241438843668326 0.396105357519584 no 1306 0.404607505067676 2047 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_179 1273-0063 6.77 µM 0.241190612935685 0.396208747300172 no 1307 0.404703692985219 1818 3108139 SGTC_2469 5655019 90.81 µM 0.240399156172855 0.39653844311274 no 1308 0.40501041615232 1981 2788239 SGTC_2294 7971431 200 µM 0.236342042068944 0.398229665250062 no 1309 0.406583632979529 1951 5741572 SGTC_3002 9075603 71.4286 µM 0.235894215467607 0.398416461172123 no 1310 0.406757378496141 1980 20105405 SGTC_722 3534-0461 190 µM 0.233884089789791 0.399255204184721 no 1311 0.407537482599084 1840 658262 SGTC_576 1073-0113 22.7 µM 0.233737072006586 0.399316566982365 no 1312 0.407594552755523 2021 5439563 SGTC_1288 0973-0013 65.5 µM 0.233597710723159 0.399374736380012 no 1313 0.407648652581201 1914 4315430 SGTC_554 4483-2211 187 µM 0.23181403723791 0.400119438517313 no 1314 0.408341226934681 1898 747107 SGTC_1627 st003713 25.6 µM 0.229776094174239 0.400970745453281 no 1315 0.409132880911051 1864 16195070 YER133W GLC7 SGTC_1404 3909-7820 48.3 µM 0.225301802914815 0.402841429510404 no 1316 0.410872248601163 2017 23741373 SGTC_2348 9022543 33.42 µM 0.224215541727219 0.403295928659331 no 1317 0.411294795382418 1920 3162678 YDL140C RPO21 SGTC_2748 diazoxide 86.69 µM 0.224149147530913 0.403323712690749 no 1318 0.411320625528237 1973 3019 A potassium channel activatior. SGTC_908 3448-7491 47.7 µM 0.223196586246974 0.403722385418446 no 1319 0.411691254356984 1885 1203031 SGTC_1953 st076800 12.1 µM 0.222496404562862 0.404015494263503 no 1320 0.411963735937457 1804 297591 SGTC_1339 1486-1321 22.7 µM 0.221936371005257 0.404249973347189 no 1321 0.412181708261129 1901 3469382 SGTC_3299 9121982 43.1275 µM 0.219688538779979 0.405191458067673 no 1322 0.413056865675011 1881 17594604 YPL160W CDC60 SGTC_2433 5607874 27.82 µM 0.217409652409479 0.406146509930262 no 1323 0.413944554780966 1892 2252428 SGTC_2217 6934799 96.0675 µM 0.217368240286296 0.406163870402582 no 1324 0.413960690028361 2015 675606 SGTC_572 0960-0087 17.7 µM 0.216256920152244 0.406629818298299 no 1325 0.414393743611042 1868 6796365 SGTC_1473 k844-0725 134 µM 0.213538957965228 0.407769945676705 no 1326 0.415453302855641 2011 54682906 SGTC_385 1494-0393 12.4 µM 0.21313581823907 0.407939121014851 no 1327 0.415610513762027 1960 3090647 SGTC_2237 6667747 47.222 µM 0.211726146213197 0.408530816775493 no 1328 0.416160344387537 1881 729940 YDL015C TSC13 SGTC_968 1309-0633 340 µM 0.211546047376434 0.408606426518298 no 1329 0.416230602258217 2049 3761976 SGTC_3188 9110789 49.47 µM 0.210210324624901 0.409167300455782 no 1330 0.416751760854222 2033 849217 SGTC_2246 7293507 91.5585 µM 0.210095808558647 0.409215394764383 no 1331 0.416796448381923 2068 887656 SGTC_2513 baicalein 25.65 µM 0.208637661665835 0.409827904645893 no 1332 0.417365553878667 1858 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_171 k064-0041 9.68 µM 0.207934520663444 0.410123345147898 no 1333 0.417640047313349 1884 53325 SGTC_467 ro 31-8220 72.8 µM 0.207447950653112 0.410327818358828 no 1334 0.41783001888348 2049 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2299 7976368 114.88 µM 0.206341591849089 0.410792838484689 no 1335 0.418262045949971 2023 2979718 SGTC_3051 9093778 49.47 µM 0.205840908793372 0.411003324760868 no 1336 0.418457592397141 2060 17217378 SGTC_1845 st056753 3.01 µM 0.204040641413925 0.411760365313277 no 1337 0.419160869828925 1852 5375839 SGTC_2723 salbutamol 83.58 µM 0.203559390637267 0.411962794555412 no 1338 0.419348915099301 2027 9884233 β2-adrenoceptor agonist SGTC_2997 9067075 71.4286 µM 0.202492414682238 0.412411681746567 no 1339 0.419765893898255 1974 27209819 SGTC_1906 st060206 94.7 µM 0.20173210378229 0.41273162191796 no 1340 0.420063081676659 2051 5133468 SGTC_2592 piperlongumine 83.33 µM 0.201435445520234 0.412856471976995 no 1341 0.420179050837122 1895 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_20 0481-0013 4.944 µM 0.200897927574452 0.413082711443454 no 1342 0.420389194117232 1906 182045 SGTC_1402 3909-7673 35.9 µM 0.200828517339007 0.413111928080523 no 1343 0.420416331786998 1982 5328014 SGTC_3348 9149464 3.537 µM 0.200368549241357 0.4133055531917 no 1344 0.420596177387302 2054 1951442 SGTC_1213 1315-0166 115 µM 0.199891374571139 0.41350644375205 no 1345 0.420782768202563 1823 768401 SGTC_1331 1472-0049 76.2 µM 0.199752370499219 0.413564968734533 no 1346 0.420837126664928 1909 24051409 SGTC_1329 1447-1697 50.6 µM 0.199552677696837 0.413649048896579 no 1347 0.420915220498457 1969 2840515 SGTC_136 0097-0015 404.482 µM 0.199492596832077 0.413674346571531 no 1348 0.420938716922145 2082 4861337 SGTC_926 2268-1401 59.4 µM 0.199348196750566 0.413735149197669 no 1349 0.42099519005552 2068 2931578 SGTC_999 SEC7.066 22.7 µM 0.198620257795887 0.414041694341109 no 1350 0.421279902947362 1970 740511 YDR170C SEC7 SGTC_2566 crystal violet carbinol 226 nM 0.197766951809859 0.41440109994857 no 1351 0.421613702037624 1795 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1555 citronellol 128 µM 0.197488780124477 0.414518279129341 no 1352 0.421722530355307 2081 8842 A terpine precursor. SGTC_1457 k015-0032 57.3 µM 0.195845627070421 0.415210608427038 no 1353 0.422365498147512 1931 4302660 SGTC_2216 7189485 200 µM 0.194244361156407 0.415885542326471 no 1354 0.422992274561681 2053 731273 SGTC_127 0180-0333 59.125 µM 0.194173091200463 0.415915588410464 no 1355 0.423020175988146 2087 771601 SGTC_2944 9067346 25.62 µM 0.193809157507656 0.41606902372604 no 1356 0.423162658158526 1977 6473075 SGTC_1064 honokiol 6.76 µM 0.192890327753778 0.416456461421065 no 1357 0.42352243006055 1956 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_75 0159-0059 199.013 µM 0.192460807681179 0.416637602564571 no 1358 0.423690632457382 2053 5377270 SGTC_1634 st006576 41 µM 0.191487597090836 0.417048099298776 no 1359 0.42407179841875 2087 3915356 SGTC_2437 5741531 144.16 µM 0.191298707051542 0.41712778293444 no 1360 0.424145787004827 2077 2262990 SGTC_838 0109-0203 71.4 µM 0.190016232184196 0.417668887343852 no 1361 0.424648205408319 1965 759422 SGTC_232 clozapine 119 µM 0.189756368615138 0.417778548541596 no 1362 0.424750023704983 1993 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3030 9087619 49.47 µM 0.189638068943063 0.417828472562394 no 1363 0.42479637688729 1959 25236973 SGTC_3114 9122766 49.47 µM 0.188752516516617 0.418202229364326 no 1364 0.42514339454549 1923 17176985 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.188710152497958 0.418220111402409 no 1365 0.425159997009087 1985 7104 SGTC_1828 st055811 49 µM 0.18758307268757 0.418695918694602 no 1366 0.425601748360327 2096 5877589 SGTC_2715 st079500 56.4 µM 0.186100718603266 0.419321889376367 no 1367 0.426182889197384 1948 28246688 SGTC_823 0417-1665 178 µM 0.186097802201269 0.41932312112076 no 1368 0.426184032699589 1973 3429856 SGTC_931 2812-0076 566 µM 0.18609007975284 0.419326382705995 no 1369 0.426187060624258 1915 3450959 SGTC_2356 9061756 188.97 µM 0.185904906533528 0.419404592493931 no 1370 0.426259667210645 2082 20104043 SGTC_141 0443-0274 32.331 µM 0.185819180996657 0.419440800622661 no 1371 0.426293281117569 2104 1627241 SGTC_346 4513-0042 7.16 µM 0.184412349965099 0.420035104916095 no 1372 0.42684499104946 1957 2827372 SGTC_2128 5255449 168.493 µM 0.183978889908157 0.420218253399172 no 1373 0.427015007822506 1997 736008 SGTC_466 geldanamycin 89.2 µM 0.183393689570398 0.420465543614932 no 1374 0.427244563447033 2098 5288382 HSP90 inhibitor. SGTC_356 1634-0012 32.5 µM 0.181974854190029 0.421065236141707 no 1375 0.427801229922647 2132 735457 SGTC_571 k831-0106 44.2 µM 0.179740287779104 0.42201008082891 no 1376 0.428678231704121 2116 4783639 SGTC_2532 xanthone 78.9 µM 0.179681449258607 0.4220349656904 no 1377 0.428701328876898 2059 7020 An insecticide. SGTC_3098 9119039 49.47 µM 0.179545971995851 0.422092264931046 no 1378 0.428754511661551 2113 17161528 SGTC_2297 7971671 152.32 µM 0.179514213658783 0.422105697154963 no 1379 0.428766978861797 2052 909016 SGTC_2641 levomentholum 100 µM 0.179270611131797 0.422208732126024 no 1380 0.428862610963435 2059 16666 SGTC_1086 cerivastatin 2.18 µM 0.179243879159917 0.422220039098017 no 1381 0.428873105504092 2100 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2676 harmalol 100 µM 0.178626115585871 0.4224813558592 no 1382 0.42911564350497 2070 5459187 A monoamine oxidase inhibitor SGTC_1867 st057372 64 µM 0.178559329294507 0.422509608805737 no 1383 0.429141865842545 2096 688837 SGTC_163 TUB2.036 7.546 µM 0.177589360480691 0.422919984545211 no 1384 0.42952274041431 2112 15992207 YJR013W GPI14 SGTC_1606 st000094 49.2 µM 0.177584528133149 0.422922029231244 no 1385 0.429524638081407 2114 1242210 SGTC_2011 4012611 177 µM 0.176728917773357 0.423284091865005 no 1386 0.429860662647399 1962 2049887 SGTC_653 0203-0016 55.2 µM 0.176477932272977 0.42339031194319 no 1387 0.429959242040952 2032 295302 SGTC_1559 coumarin 343 70.1 µM 0.175434456272151 0.42383198313061 no 1388 0.43036913410196 2075 108770 A hepatotoxic, DNA x-linker. SGTC_3266 9136860 49.47 µM 0.174795917750103 0.424102304015232 no 1389 0.430619998059842 2021 4871271 YPR165W RHO1 SGTC_274 sirtinol 40.1 µM 0.174671076277829 0.424155158970118 no 1390 0.430669048064417 1910 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2025 5147754 141 µM 0.174198756677485 0.424355140360757 no 1391 0.430854631313512 2079 315777 YLR208W SEC13 SGTC_11 0438-0307 1.3 µM 0.173835373306766 0.424509011117463 no 1392 0.430997421865712 2123 4011476 SGTC_1286 0929-0070 131 µM 0.17382538345512 0.42451324137466 no 1393 0.431001347479464 2043 1420408 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.173737132463338 0.424550612116378 no 1394 0.431036026899821 2063 229346 A bile salt which induces apoptosis. SGTC_1248 0469-0687 58.6 µM 0.173676362872003 0.424576345985843 no 1395 0.431059907441482 2031 4017482 SGTC_1270 0831-1170 17.3 µM 0.17303855228995 0.424846456599533 no 1396 0.43131056216591 2071 6764716 SGTC_2953 9074162 66.49 µM 0.170501749070061 0.425921132246412 no 1397 0.432307779472546 2134 16451992 SGTC_392 N-ethylmaleimide 8.33 µM 0.170373861548498 0.425975324366761 no 1398 0.432358063530279 1965 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1880 MG-132 525 µM 0.168523978945127 0.426759364850021 no 1399 0.433085540483003 2098 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_114 0364-0001 490.298 µM 0.167705281966301 0.427106447877616 no 1400 0.43340757031955 1959 4003655 SGTC_1843 st055809 45.5 µM 0.167393280974955 0.427238734209359 no 1401 0.433530305796693 2005 16413835 SGTC_550 4123-0385 25.7 µM 0.167301336310895 0.42727771969299 no 1402 0.433566476367391 1995 5731123 SGTC_1208 2323-2347 50.3 µM 0.166920008679443 0.427439414108981 no 1403 0.433716494684867 2140 5412760 SGTC_1509 1326-1131 80 µM 0.166309679487171 0.427698237449797 no 1404 0.433956624499073 2106 768313 SGTC_1172 0370-0043 85 µM 0.165702674806904 0.427955681822569 no 1405 0.43419547048359 2055 376585 SGTC_1982 st072467 71.9 µM 0.164513752846495 0.428460019209192 no 1406 0.434663360522287 1974 3163533 SGTC_217 ketoconazole 989 nM 0.163685594807202 0.42881139064498 no 1407 0.434989329133594 2074 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2203 7227154 166.4 µM 0.163119039347331 0.429051801690459 no 1408 0.435212354668229 2112 896304 SGTC_2101 5377231 179.231 µM 0.163089552502075 0.429064314802604 no 1409 0.435223962780663 2065 2844213 SGTC_3054 9094397 49.47 µM 0.162701488901492 0.429229001090643 no 1410 0.435376737319252 2017 2598354 SGTC_3129 9127257 49.47 µM 0.161908531896345 0.42956555416756 no 1411 0.435688941995167 1877 837894 SGTC_2145 5634607 200 µM 0.161696004327065 0.429655765507436 no 1412 0.435772625609837 1991 308662 SGTC_3149 9097855 49.47 µM 0.161508698641152 0.429735273987966 no 1413 0.43584638038725 2114 25236625 YMR079W SEC14 SGTC_1058 3448-5425 97.3 µM 0.161448498054979 0.429760828847619 no 1414 0.435870085858766 2115 7279705 SGTC_289 k017-0060 526 µM 0.160709977673996 0.430074351119573 no 1415 0.436160915271174 2053 5512909 SGTC_1922 5578187 25 µM 0.159362486227301 0.430646511896564 no 1416 0.436691646403322 2118 1350412 SGTC_1173 0443-0020 122 µM 0.159229069237158 0.430703170267906 no 1417 0.436744201042856 1986 5331295 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.157711792174267 0.431347614419491 no 1418 0.437341953989532 2045 65057 A dermal irritant. YDR527W RBA50 SGTC_1395 3486-0190 4.35 µM 0.156808711989907 0.431731273141819 no 1419 0.43769780331117 2128 6748079 SGTC_1354 1498-1681 81 µM 0.156631850221529 0.43180641750016 no 1420 0.43776749975533 2013 5754243 SGTC_1382 3002-2117 298 µM 0.155533547568325 0.43227311530913 no 1421 0.438200354296027 2133 1497314 SGTC_78 0336-0123 156.75 µM 0.154841790792954 0.432567109590352 no 1422 0.438473022109594 1925 6765896 SGTC_1983 st071813 46.9 µM 0.15318284486062 0.433272307810508 no 1423 0.439127042910728 2025 11838595 SGTC_1346 1488-2224 62.4 µM 0.153165356884207 0.433279742877521 no 1424 0.439133938237459 2149 3722427 SGTC_779 1360-0071 233 µM 0.153050052790975 0.433328765358762 no 1425 0.439179401901253 2164 7566 SGTC_2245 6637752 200 µM 0.152578391586733 0.433529306662219 no 1426 0.439365383233558 2134 681890 SGTC_1572 epiandrosterone 68.9 µM 0.152552742385411 0.4335402127021 no 1427 0.439375497387004 2054 441302 A steroid. SGTC_149 3970-0822 46.1 µM 0.151031637053522 0.434187076861805 no 1428 0.439975379693285 2102 3114250 YBL034C STU1 SGTC_804 1595-0054 20.9 µM 0.150446012472635 0.434436166239216 no 1429 0.440206370819125 1996 761523 Stimulates phospholipase C. SGTC_750 4073-0104 132 µM 0.149501111865024 0.434838124812401 no 1430 0.440579116043089 2134 22330957 SGTC_637 1181-0519 7.26 µM 0.148959707680357 0.435068467304265 no 1431 0.440792713393752 2104 6252091 YGR060W ERG25 SGTC_1663 st014140 55.4 µM 0.14879817771784 0.435137195119615 no 1432 0.440856444301178 2165 4207120 SGTC_3103 9120822 49.47 µM 0.14847883497347 0.435273074927887 no 1433 0.440982444025573 2131 17141819 SGTC_419 nsc-638432 893 µM 0.144416840306621 0.437002108489335 no 1434 0.442585659781556 2045 368090 SGTC_693 4161-2696 114 µM 0.144415497577156 0.437002680238066 no 1435 0.442586189896145 2115 805759 SGTC_488 nitrendipine 139 µM 0.144220991515437 0.437085504412698 no 1436 0.442662982698438 2145 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2127 5253358 187.912 µM 0.144107979537392 0.437133628209535 no 1437 0.442707601868126 2042 20612 SGTC_2921 7974240 10.71 µM 0.14378088707874 0.437272918959584 no 1438 0.442836747970702 2101 2979074 YDR527W RBA50 SGTC_2045 5106652 78.05 µM 0.14363303165655 0.437335885032593 no 1439 0.442895127805756 2131 673349 SGTC_3338 9144300 39.5675 µM 0.142344106298066 0.437884857004458 no 1440 0.443404104703657 2088 4901274 SGTC_3190 9110366 49.47 µM 0.142086797818477 0.437994462762795 no 1441 0.443505723093533 2156 17123768 SGTC_3013 9080133 71.4286 µM 0.142022819023994 0.43802171656491 no 1442 0.443530990704448 2106 17050193 SGTC_1043 0916-0009 19.3 µM 0.141711310979487 0.438154417520786 no 1443 0.443654020121982 2208 3101130 SGTC_454 lyso-paf C-16 6.67 µM 0.141684452436729 0.438165859459037 no 1444 0.443664628098908 2001 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2777 climbazole 1.536 µM 0.140975438631489 0.438467923258522 no 1445 0.443944672836434 2175 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2785 7756463 72.73 µM 0.139239138438065 0.439207796749157 no 1446 0.444630590859202 2082 2201551 SGTC_3210 9128157 49.47 µM 0.138899738352194 0.439352447060317 no 1447 0.444764688864246 1900 17590849 SGTC_1348 1493-0373 93.8 µM 0.138785585288684 0.439401100242372 no 1448 0.444809792507913 2105 3010129 SGTC_1661 st013063 9.66 µM 0.137322910923092 0.440024587502506 no 1449 0.445387780843589 2129 721395 SGTC_1937 st074714 47.2 µM 0.137025884605766 0.440151217722923 no 1450 0.445505167565636 2094 17250970 SGTC_246 cycloheximide 667 µM 0.136591812144116 0.4403362853674 no 1451 0.44567672440063 2057 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1969 st069479 40.1 µM 0.136497875034045 0.440376337355342 no 1452 0.445713852153132 2164 3895485 SGTC_1753 st043925 64 µM 0.136235193594668 0.440488340139923 no 1453 0.445817677028491 2159 670181 SGTC_2016 5121758 140 µM 0.136148041526876 0.440525501314084 no 1454 0.445852124716601 2169 2795203 SGTC_1290 0986-0249 10.2 µM 0.13560956707762 0.440755115534536 no 1455 0.446064970946084 2176 53329 SGTC_2899 9053889 58.44 µM 0.134607414599791 0.441182502548518 no 1456 0.446461139482259 2203 6470052 SGTC_2804 7954240 19.48 µM 0.13324699877558 0.441762787318642 no 1457 0.446999021279242 2144 828705 SGTC_2687 chenodiol 100 µM 0.132208805400162 0.442205712417605 no 1458 0.44740956827939 2097 5702181 A cholesterol synthesis inhibitor. SGTC_977 1348-1378 135 µM 0.131760333635039 0.442397066593371 no 1459 0.447586931056064 2175 X977 SGTC_1353 1498-1206 8.11 µM 0.131046916842857 0.442701495334849 no 1460 0.447869096562344 2130 6756808 SGTC_654 1124-0271 80.9 µM 0.130261840954787 0.443036541493924 no 1461 0.448179634645215 2031 5403748 SGTC_2499 avocadenofuran 51.48 µM 0.130173976028634 0.443074042071667 no 1462 0.448214391743551 2147 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3201 9113999 49.47 µM 0.129558025895261 0.443336942675906 no 1463 0.448458056874881 2120 16649224 SGTC_2885 9057732 51.95 µM 0.129348502044303 0.443426377598938 no 1464 0.448540947334388 2096 6471414 SGTC_1772 st048439 82.2 µM 0.129225255450238 0.443478986558356 no 1465 0.448589706397777 2034 2927068 YDL195W SEC31 SGTC_558 k064-0027 21.3 µM 0.128465683171284 0.443803239033029 no 1466 0.448890227011493 2121 5088526 SGTC_809 3998-0021 90 µM 0.128327342695204 0.443862299012382 no 1467 0.448944963825426 2196 715485 SGTC_743 1275-0778 158 µM 0.127757002494658 0.444105800414522 no 1468 0.449170639089274 2161 2849257 YMR203W TOM40 SGTC_732 3970-1727 52.7 µM 0.12773966444496 0.444113203063251 no 1469 0.449177499759512 2182 1275699 SGTC_1424 4048-1941 275 µM 0.126260518922817 0.444744810132812 no 1470 0.449762853714536 2171 X1424 SGTC_3350 9150499 3.57 µM 0.125695135635794 0.444986270512647 no 1471 0.449986626264148 2188 4910996 YPR165W RHO1 SGTC_1451 4152-0210 104 µM 0.125274180868861 0.445166062520341 no 1472 0.450153245910114 2182 659563 SGTC_3151 9099821 49.47 µM 0.125089238602343 0.445245055909258 no 1473 0.450226451365012 2091 17174189 SGTC_1093 fluphenazine 7.97 µM 0.124312717962955 0.445576750657705 no 1474 0.450533838966659 2118 6602611 An atypical antipsychotic. SGTC_422 cantharidin 155 µM 0.123935176840409 0.445738033051198 no 1475 0.450683300279214 2103 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2571 chrysanthemic acid 100 µM 0.122948030803296 0.446159775906421 no 1476 0.451074125518266 2020 2743 An insecticide. SGTC_2286 7945697 125 µM 0.122417537047815 0.446386446342549 no 1477 0.451284175205685 2075 1245733 SGTC_1471 k673-0312 37 µM 0.12163534098847 0.44672069658421 no 1478 0.451593911614048 2199 24099884 SGTC_2816 7982706 58.44 µM 0.121495443336675 0.446780482043577 no 1479 0.45164931182992 2075 2981853 SGTC_1052 3253-3998 198 µM 0.120650672192157 0.447141521843724 no 1480 0.451983865679072 2177 5450317 SGTC_1975 st070967 30.8 µM 0.12037758433151 0.447258244005718 no 1481 0.452092023689071 2215 261391 SGTC_882 0843-0131 351 µM 0.119514887010769 0.447627004735913 no 1482 0.452433723220189 2205 5425421 SGTC_2624 nerol 100 µM 0.119146545411171 0.447784466487541 no 1483 0.452579627723193 2149 637566 A natural product oil. SGTC_104 0074-0074 590.992 µM 0.118292351014323 0.448149656288557 no 1484 0.452918008927035 2221 3943124 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.117853915734977 0.448337115593601 no 1485 0.453091704299484 2072 6857784 SGTC_1940 st075990 51.1 µM 0.117850630544749 0.448338520267497 no 1486 0.453093005830721 2126 1084979 SGTC_939 1165-0479 45.3 µM 0.114045608473785 0.449965892954353 no 1487 0.454600819469522 2224 1377347 SGTC_1406 3909-7906 11.9 µM 0.113355410446861 0.450261175247376 no 1488 0.454874394548566 2188 X1406 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.110974454121207 0.451280012428964 no 1489 0.455818302121197 2123 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2555 cholic acid 100 µM 0.108548819152382 0.452318298189476 no 1490 0.45678017858659 2124 6708657 Influences liver metabolism. SGTC_1142 3253-1408 9.78 µM 0.108387216470478 0.452387483399097 no 1491 0.456844270586655 2241 256655 SGTC_1371 2421-0008 32.7 µM 0.108356462331134 0.452400650000194 no 1492 0.456856467877156 2107 2827552 SGTC_499 genistein 192 µM 0.108343534231163 0.452406184852396 no 1493 0.456861595257325 2228 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2506 ethyl hematommate 54.16 µM 0.107457231692902 0.452785655765378 no 1494 0.457213126484038 2025 3940691 An allergen. SGTC_3141 9094609 49.47 µM 0.107025427777591 0.452970548490874 no 1495 0.457384403580677 2019 25236309 YDL196W YDL196W SGTC_313 3474-0040 5.03 µM 0.105221244632575 0.453743185702825 no 1496 0.45810012675814 2181 1043375 YIL048W NEO1 SGTC_1548 st061468 90.8 µM 0.104961966845414 0.453854235267532 no 1497 0.45820299401261 2207 390799 SGTC_1157 4092-0394 27.6 µM 0.103486544497087 0.454486232138976 no 1498 0.458788414045763 2194 3659885 SGTC_3236 9132701 49.47 µM 0.0999894946227985 0.455984650152488 no 1499 0.460176332861404 2128 24282524 SGTC_256 clotrimazole 625 nM 0.099258441415918 0.456297972117211 no 1500 0.460466537179707 2219 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2792 7535235 81.82 µM 0.099073917224577 0.456377061610829 no 1501 0.460539790609733 2110 1281891 SGTC_1458 k015-0034 6.33 µM 0.0983686406966459 0.45667936830017 no 1502 0.46081978749104 2043 3598957 SGTC_2966 9084041 48.03 µM 0.0969232147027732 0.457299007628674 no 1503 0.46139368646629 2171 17741380 SGTC_1056 3448-1962 115 µM 0.0963454015014198 0.457546739365053 no 1504 0.461623126795821 2153 715507 SGTC_535 2293-4129 48.2 µM 0.0958180845729735 0.457772835719086 no 1505 0.461832527016999 2230 396118 YIL048W NEO1 SGTC_805 3852-0218 479 µM 0.0938568629338958 0.458613863146936 no 1506 0.462611430452062 2160 6615355 SGTC_1352 1496-0991 99 µM 0.0937793910858135 0.458647089100271 no 1507 0.462642201528309 2207 3000039 SGTC_769 0302-0231 76 µM 0.0931306687782884 0.458925322992348 no 1508 0.462899876573365 2220 571869 YER009W NTF2 SGTC_3113 9123498 49.47 µM 0.0927642552049125 0.459082484921208 no 1509 0.463045424368746 2257 8897275 SGTC_2092 5303694 80.6725 µM 0.0910905353701048 0.459800456962193 no 1510 0.463710326528991 2145 1963699 SGTC_2877 9040724 71.43 µM 0.0907433824111658 0.459949390923837 no 1511 0.463848249314296 2248 6463895 SGTC_1493 4348-0038 111 µM 0.0902521839126538 0.460160132235072 no 1512 0.464043408361439 2245 800424 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0900846556535091 0.460232010271779 no 1513 0.464109971326454 2255 88881 An O-methylated flavonoid and antioxidant. SGTC_1327 1436-0082 2.18 µM 0.0889428385439062 0.460721941648594 no 1514 0.464563669102857 2106 15992205 SGTC_2225 6654152 15.4 µM 0.087620524546442 0.46128939517409 no 1515 0.4650891443449 2232 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_317 4495-0002 170 µM 0.0872982861764503 0.461427691488484 no 1516 0.465217208127306 2114 15991618 SGTC_2005 4024620 188 µM 0.08694093716946 0.461581061827528 no 1517 0.465359229770521 2232 236743 SGTC_903 1134-0042 114 µM 0.0867367634678078 0.461668693544183 no 1518 0.465440376750854 2142 701009 SGTC_3093 9117344 49.47 µM 0.0866036857648268 0.461725811733543 no 1519 0.465493268047078 2190 24824913 SGTC_924 2046-0044 21.3 µM 0.0865489808939432 0.46174929180257 no 1520 0.465515010495291 2269 3623589 SGTC_855 0428-0020 25 µM 0.0857567523616646 0.462089341887104 no 1521 0.465829893193764 2138 6812414 SGTC_878 0828-0289 13.7 µM 0.0850088774706361 0.462410379389067 no 1522 0.466127166529265 2156 745350 YLR208W SEC13 SGTC_377 3970-0964 33.1 µM 0.0845399137515451 0.462611702224603 no 1523 0.466313584911786 2216 16481235 SGTC_1145 3546-0597 10.2 µM 0.0845041872875126 0.462627039738318 no 1524 0.466327786888808 2151 875334 SGTC_194 1486-1323 56.904 µM 0.084246162625261 0.462737812404867 no 1525 0.466430358074229 2137 5178754 SGTC_1151 3909-8316 15.3 µM 0.0826085048195323 0.463440942923822 no 1526 0.467081419262243 2174 800431 SGTC_319 1348-1596 45.5 µM 0.0824334553262849 0.463516107448187 no 1527 0.467151016533601 2252 5380505 SGTC_781 4335-2806 94.4 µM 0.0824121377480839 0.46352526109484 no 1528 0.46715949217819 2242 845254 SGTC_2653 dihydrofissinolide 100 µM 0.0819899142787866 0.463706565420166 no 1529 0.467327366846169 2211 6857746 SGTC_584 0986-0246 15.4 µM 0.0816017383446537 0.463873256258926 no 1530 0.467481709453961 2266 53315 YDR232W HEM1 SGTC_3001 9076041 71.4286 µM 0.081462503028259 0.463933048353462 no 1531 0.467537071991543 2244 16004211 SGTC_3029 9088683 49.47 µM 0.0809691504682524 0.464144916257095 no 1532 0.467733243143366 2197 25236615 SGTC_791 1348-1292 225 µM 0.0809460967853631 0.464154816800375 no 1533 0.467742410142031 2231 5437054 SGTC_709 3807-1509 243 µM 0.0798931671228097 0.46460702736063 no 1534 0.468161112152625 2260 1886677 YPL242C IQG1 SGTC_1255 0566-0045 221 µM 0.0795024453018982 0.464774845609869 no 1535 0.468316493350937 2182 2788469 SGTC_56 0957-0365 83.25 µM 0.0787889886777158 0.465081297268721 no 1536 0.468600231290887 2264 6752360 SGTC_672 1441-0018 53.7 µM 0.0781940077959791 0.465336875782312 no 1537 0.468836864255452 2227 251141 SGTC_2627 acetyl isogambogic acid 100 µM 0.0780126498589994 0.465414782296837 no 1538 0.468908995264182 2178 6857789 A caspase activator and apoptosis inducer. SGTC_2341 7987486 176.74 µM 0.0777907787094688 0.465510094005414 no 1539 0.46899724087264 2253 1258686 SGTC_3242 9133940 49.47 µM 0.0765107411480824 0.466060012738518 no 1540 0.469506384412459 2246 17248444 SGTC_1997 st073024 93.8 µM 0.0763366996681218 0.466134787971229 no 1541 0.469575614449823 2286 686268 SGTC_97 0535-0701 19.132 µM 0.0759854490741683 0.466285703018228 no 1542 0.469715337341881 2258 2832013 YGL099W LSG1 SGTC_2265 7929201 200 µM 0.0756615589303046 0.466424866926571 no 1543 0.469844179909979 2277 1265108 SGTC_906 1165-0455 526 µM 0.0755078253313305 0.466490922144775 no 1544 0.469905335799527 2283 3252859 SGTC_446 go6976 132 µM 0.0745469392168145 0.466903810066214 no 1545 0.470287596473765 2260 3501 A protein kinase C inhibitor. SGTC_2267 7931562 200 µM 0.0739568100743444 0.46715740326735 no 1546 0.470522375833981 2204 934880 SGTC_1179 1021-1431 9.29 µM 0.0739437095254872 0.467163033051358 no 1547 0.470527587925785 2207 2840958 SGTC_1721 st082152 9.2685 µM 0.0737782941734926 0.467234118630439 no 1548 0.470593399343023 2278 5296051 SGTC_1683 st010134 710 nM 0.0734738025791748 0.467364973552568 no 1549 0.470714545114973 2271 3818134 SGTC_545 4218-0007 221 µM 0.0726081286469332 0.467737015176753 no 1550 0.47105897903586 2213 2840508 SGTC_2054 5233173 129 µM 0.0711359230883993 0.468369791103523 no 1551 0.471644789043631 2227 6889 SGTC_2082 5219693 150 µM 0.070655127190286 0.468576461747865 no 1552 0.471836117424102 2276 2834649 SGTC_1498 4478-3555 97.6 µM 0.0704423369209587 0.468667932585306 no 1553 0.471920797465293 2286 3437919 SGTC_1755 st041960 45.185 µM 0.0704416148401147 0.468668242984553 no 1554 0.471921084820049 2219 2257073 SGTC_960 1222-0186 7.7 µM 0.0703060269996103 0.468726528157837 no 1555 0.471975042764052 2221 3126296 SGTC_3036 9090181 49.47 µM 0.0694672916645776 0.469087090341084 no 1556 0.472308833603919 2277 25236586 SGTC_2249 haloperidol 116.36 µM 0.0690316892966399 0.469274360556211 no 1557 0.472482197622939 2249 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2700 st077718 96.8 µM 0.0688042384992703 0.469372146841915 no 1558 0.47257272212558 2204 904970 SGTC_1123 mangostin 811.285 nM 0.0678116718447268 0.469798895430762 no 1559 0.472967776181554 2158 5281650 An antioxidant. SGTC_2445 5742597 35.57 µM 0.0674984644121743 0.469933564472599 no 1560 0.473092442230461 2214 1774255 SGTC_2851 9015922 71.43 µM 0.0670122584965866 0.470142624061181 no 1561 0.473285972134615 2264 2996893 SGTC_112 phenothiazine 287.218 µM 0.0658062045907443 0.470661240433311 no 1562 0.473766058198588 2298 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_737 1950-0117 57.9 µM 0.0656544405911958 0.470726504156403 no 1563 0.473826472624008 2304 5393513 SGTC_2129 girgensonine 121.053 µM 0.0652362785047136 0.470906332252957 no 1564 0.473992938283037 2236 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2807 7945238 51.95 µM 0.0651152575729871 0.470958377687153 no 1565 0.474041116213689 2245 17148797 SGTC_3048 9093155 49.47 µM 0.0649824948276935 0.471015473295905 no 1566 0.474093968948264 2308 25236002 SGTC_2949 9072542 2.23 µM 0.0647093307388872 0.471132951422271 no 1567 0.474202716770029 2222 16457352 SGTC_2466 5983409 37.09 µM 0.0637192008283507 0.471558791942389 no 1568 0.47459690788199 2178 2879657 SGTC_3110 9122132 49.47 µM 0.0636584127884838 0.47158493706151 no 1569 0.474621109667007 2268 918317 SGTC_1418 3966-3099 2.4 µM 0.0634661209527726 0.471667643165324 no 1570 0.47469766819959 2276 740335 SGTC_3278 9139605 49.47 µM 0.062567583054436 0.472054126924592 no 1571 0.475055421898004 2253 7958859 SGTC_2746 daunorubicin 9.88 µM 0.0621464531206992 0.47223527458489 no 1572 0.475223102112084 2293 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1014 4130-3005 69.3 µM 0.0620916813501138 0.472258834905285 no 1573 0.475244910769134 2279 743608 SGTC_1956 st077085 54 µM 0.0611884591758712 0.472647373872762 no 1574 0.475604560377395 2233 24208685 SGTC_1684 st024538 14.6195 µM 0.0611856813136712 0.472648568865727 no 1575 0.475605666511532 2275 6732859 SGTC_887 0885-0007 9.62 µM 0.0610582879030575 0.472703371787115 no 1576 0.475656394283815 2286 5719458 SGTC_1540 guanosine 70.6 µM 0.0593151884519197 0.473453281049919 no 1577 0.476350531889732 2291 6802 Guanosine is a purine nucleoside SGTC_2993 9054257 71.4286 µM 0.0593086463133966 0.473456095761435 no 1578 0.476353137238677 2299 6470217 YGL055W OLE1 SGTC_2013 4024628 200 µM 0.058517219611982 0.473796611563331 no 1579 0.476668323365082 2248 5230760 SGTC_597 k018-0003 82.8 µM 0.0576755968998524 0.474158745482627 no 1580 0.477003516091627 2280 6786234 SGTC_192 3455-0609 60.9 µM 0.05737040324153 0.474290069682122 no 1581 0.477125069474997 2244 3769639 SGTC_2667 digitoxin 100 µM 0.0561348660411767 0.474821747183006 no 1582 0.477617184316604 2318 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_73 0327-0325 16.231 µM 0.0558718399679006 0.474934938625305 no 1583 0.477721952113311 2323 53298 SGTC_2539 epi(13)torulosol 80 µM 0.0548231568532558 0.475386252137176 no 1584 0.478139675821093 2251 6708597 SGTC_2829 7992743 58.44 µM 0.0543981182790479 0.475569181675593 no 1585 0.47830898901633 2332 16462845 SGTC_261 5-fluorouridine 15.376 µM 0.0541085187841119 0.475693823437289 no 1586 0.478424352591967 2304 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_451 chloral hydrate 100 µM 0.0534245504797743 0.475988208420914 no 1587 0.478696822343692 2238 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2833 9001315 45.46 µM 0.0534196586712053 0.475990313938662 no 1588 0.47869877111016 2194 2989378 SGTC_1316 1272-0050 65.9 µM 0.0529888159111519 0.476175758625745 no 1589 0.478870409402557 2324 7340392 SGTC_2171 5739187 198.077 µM 0.0525367872309114 0.476370327769234 no 1590 0.479050491911948 2305 2262761 SGTC_840 0245-0196 390 µM 0.0513957639643138 0.476861489524782 no 1591 0.479505080090429 2279 3827528 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0511270474982469 0.476977165621925 no 1592 0.479612141692829 2270 279621 SGTC_1201 1889-3372 45.9 µM 0.0510890295095333 0.476993531625747 no 1593 0.479627288880552 2221 5392199 SGTC_2619 obliquin 87.91 µM 0.0509970727843444 0.477033117365665 no 1594 0.479663926547321 2288 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1927 st060202 13.8 µM 0.050362298014266 0.477306382811379 no 1595 0.479916840033397 2332 688887 SGTC_2589 lobaric acid 100 µM 0.0499363649155039 0.477489749583417 no 1596 0.480086549214088 2271 73157 A novel microtubule depolymerizer. SGTC_1996 st072960 66.8 µM 0.0490533575417009 0.477869904729087 no 1597 0.480438386958223 2335 1719405 SGTC_1375 2910-0797 186 µM 0.0489757109327997 0.477903334362595 no 1598 0.480469326286404 2282 742508 SGTC_1347 1493-0251 600 nM 0.0484769313147698 0.478118080468427 no 1599 0.480668074483093 2320 3986378 SGTC_32 0928-0142 34.1 µM 0.0484482089323008 0.478130446885087 no 1600 0.480679519607831 2330 2244242 SGTC_1707 st032323 6.317 µM 0.0464038131961765 0.479010714478827 no 1601 0.481494198648896 2282 3132057 YMR211W DML1 SGTC_603 3794-0023 45.9 µM 0.0461855293295554 0.479104708382786 no 1602 0.481581188044596 2325 3802260 SGTC_2105 5350118 200 µM 0.0440861718018811 0.480008758677479 no 1603 0.482417857685845 2291 2133313 SGTC_2399 5884133 200 µM 0.0437087692774459 0.480171291279617 no 1604 0.482568274513136 2290 722445 SGTC_95 0471-0001 561.058 µM 0.043201975717139 0.480389552754017 no 1605 0.482770265083148 2284 4015405 SGTC_358 0075-0058 9.45 µM 0.0431821587840846 0.480398087459496 no 1606 0.482778163524687 2354 1069125 SGTC_2894 9048625 32.47 µM 0.042794382409809 0.480565095788929 no 1607 0.482932721038282 2325 4092861 SGTC_2194 5927483 104.545 µM 0.0426618548987357 0.48062217379465 no 1608 0.482985543624821 2316 760979 SGTC_1308 1187-1617 41.4 µM 0.0417417161269449 0.481018477392527 no 1609 0.483352299132266 2322 2882570 SGTC_76 0433-0009 400.328 µM 0.0413832382521749 0.481172878846257 no 1610 0.483495187643393 2174 2841569 SGTC_2910 7948405 25.97 µM 0.0411431584169724 0.48127628618261 no 1611 0.483590884136519 2311 2971328 SGTC_2638 epoxomicin 18 µM 0.0400143360183008 0.481762510043137 no 1612 0.484040848478541 2343 9915668 A protesome inhibitor. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0398547733258885 0.481831241561599 no 1613 0.484104454044543 2303 115019 SGTC_365 0121-0052 13.6 µM 0.0368432617518825 0.483128547070858 no 1614 0.485304989779133 2323 3101739 SGTC_47 0149-0135 24.25 µM 0.0365913545755417 0.483237072479145 no 1615 0.485405418482408 2333 5239155 SGTC_1447 4239-0816 81.9 µM 0.0363540830741798 0.483339293754031 no 1616 0.485500013177353 2312 1341554 SGTC_3090 9117696 49.47 µM 0.0359556988446913 0.483510928051424 no 1617 0.485658841646967 2324 7923821 SGTC_873 0591-4978 488 µM 0.035552931083463 0.483684453994438 no 1618 0.485819420062811 2332 3305145 SGTC_2663 amphotericin b 100 µM 0.0352773130842226 0.483803201312218 no 1619 0.485929306802317 2340 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_664 1222-0054 14.9 µM 0.035121759835237 0.483870220542172 no 1620 0.485991325137638 2333 6813991 SGTC_2421 5690543 90.72 µM 0.0338442976656529 0.48442062489679 no 1621 0.486500655866744 2292 3397993 SGTC_277 nystatin 15.5 µM 0.0338178216689383 0.484432032600273 no 1622 0.486511212218434 2342 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1158 4092-0494 91.8 µM 0.0336138417661354 0.484519921776503 no 1623 0.486592542186516 2292 1148199 SGTC_1516 st013856 110 µM 0.0328652926626892 0.484842456844828 no 1624 0.486891005139115 2297 5281404 A mutagen and neurotoxin. SGTC_1216 1165-0504 9.65 µM 0.0325237384407099 0.484989629140889 no 1625 0.487027192751592 2339 6304004 SGTC_2674 ligustilide 100 µM 0.0319082186772376 0.485254855596189 no 1626 0.487272622210892 2319 5319022 A signalling regulator. SGTC_2867 9039098 71.43 µM 0.0315522861527536 0.485408229320775 no 1627 0.487414547279431 2351 6463460 SGTC_2552 juarezic acid 87.02 µM 0.0310875425458308 0.485608493720338 no 1628 0.487599862238666 2350 1549512 SGTC_2204 7233102 200 µM 0.0306017310308627 0.485817840450166 no 1629 0.487793580817351 2335 2172480 SGTC_2601 securinine 100 µM 0.030586119471787 0.485824567875062 no 1630 0.487799806014292 2330 442872 A GABA receptor antagonist. SGTC_843 0310-0051 143 µM 0.0295778659772786 0.48625905886181 no 1631 0.488201858990277 2327 2065037 SGTC_1009 4106-0057 9.87 µM 0.0293449688303722 0.486359424562494 no 1632 0.488294731194825 2366 2928005 SGTC_2842 9000675 19.48 µM 0.0275546446609703 0.487130982956445 no 1633 0.489008678116554 2315 2989072 SGTC_1109 tnp00067 928.257 nM 0.0268256913232273 0.487445146768144 no 1634 0.489299380938063 2332 676295 SGTC_1818 st052136 56.3 µM 0.0266681410475011 0.48751304870901 no 1635 0.489362211925687 2319 674169 SGTC_1903 st060211 78.3 µM 0.0263873423189154 0.487634069886385 no 1636 0.489474195001077 2357 688960 SGTC_635 k038-0028 24.7 µM 0.0259774397491313 0.487810735446995 no 1637 0.489637666424992 2332 4035102 SGTC_1939 st074455 53.6 µM 0.0256800358168386 0.487938916265678 no 1638 0.489756273857991 2365 1644229 SGTC_636 0kpi-0074 126 µM 0.0246318630942538 0.488390687580542 no 1639 0.490174301965487 2340 616434 SGTC_1604 st002052 72.4 µM 0.0245962239093165 0.488406048636029 no 1640 0.49018851563686 2293 6254834 YHR062C RPP1 SGTC_382 3229-0966 23.2 µM 0.0245781768634637 0.48841382720636 no 1641 0.490195713190588 2348 5722370 SGTC_1603 st002045 67.8 µM 0.0244274033258714 0.488478813225599 no 1642 0.49025584507554 2368 5887985 SGTC_1520 flindersine 88 µM 0.0232782382517364 0.488974133301626 no 1643 0.490714165184784 2359 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_837 0091-0265 12.5 µM 0.0224628198363993 0.489325610235092 no 1644 0.491039384991834 2357 759367 SGTC_1262 0737-0114 49.6 µM 0.0217890679382927 0.489616029676577 no 1645 0.491308107319856 2368 765919 SGTC_736 0958-0254 92.6 µM 0.0205099918184692 0.490167387963395 no 1646 0.491818270717665 2345 6812352 SGTC_3260 9137109 49.47 µM 0.0193939111700041 0.4906485008429 no 1647 0.492263433839407 2372 17478346 SGTC_514 4466-0038 2.65 nM 0.0190566103233837 0.490793905035388 no 1648 0.492397972541935 2289 5722064 SGTC_2065 5221596 34.26 µM 0.0186623779255484 0.490963852921896 no 1649 0.492555220545205 2352 788581 SGTC_213 1246-0773 967 nM 0.0182731941469217 0.491131626030806 no 1650 0.492710455933887 2323 6251622 SGTC_1896 st058441 89 µM 0.0162174637532511 0.492017855508666 no 1651 0.493530451617675 2347 688759 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0160798386260039 0.492077187431684 no 1652 0.493585348941236 2332 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2951 9072950 58.06 µM 0.0160605760485802 0.492085491785056 no 1653 0.493593032605577 2387 16488155 SGTC_2201 6605497 169.863 µM 0.0159974244354007 0.492112717309624 no 1654 0.49361822321784 2362 670741 SGTC_402 epigallocatechin gallate 10 µM 0.0159950862901055 0.49211372531676 no 1655 0.493619155883523 2350 65064 An antioxidant. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0157643047371226 0.492213218718585 no 1656 0.493711212794856 2390 16623 A steroid. SGTC_68 0986-0284 82.829 µM 0.015003174864026 0.492541356665327 no 1657 0.494014823746456 2281 423278 YIL048W NEO1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0142871928837766 0.492850035085221 no 1658 0.494300428594176 2370 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3139 9095020 49.47 µM 0.0130956064664343 0.49336376832699 no 1659 0.494775758215279 2382 25236292 SGTC_2797 7859098 81.82 µM 0.0130572202254289 0.493380318122499 no 1660 0.494791070800576 2371 972681 SGTC_1264 0783-0040 158 µM 0.0102228700689005 0.494602345842956 no 1661 0.495921735937162 2379 2855798 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.00930989255879273 0.494995986677439 no 1662 0.496285943884459 2369 689007 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.00930721801613246 0.494997139844849 no 1663 0.496287010826381 2383 75037 A free radical scavenger. SGTC_106 0092-0003 11.579 µM 0.00928768015181253 0.495005563876409 no 1664 0.496294804969646 2389 1072148 SGTC_3015 9080845 49.47 µM 0.00876524330306808 0.495230820861229 no 1665 0.496503218624446 2384 5296973 SGTC_2551 apiole 73.87 µM 0.00633853233267623 0.496277154815767 no 1666 0.497471308389352 2392 10659 A possible DNA adduct former. SGTC_1231 0242-0792 125 µM 0.00598555144753971 0.496429353195408 no 1667 0.497612124714399 2387 3707635 SGTC_557 1315-0110 16.2 µM 0.0049020699220794 0.496896532160598 no 1668 0.498044364879015 2400 6833801 SGTC_478 N-arachidonylglycine 10 µM 0.00359659701118758 0.497459435663573 no 1669 0.498565168480052 2400 5283389 SGTC_3240 9133527 49.47 µM 0.00325741567836998 0.497605687262181 no 1670 0.498700481459202 2399 17617455 SGTC_901 1112-0062 60.1 µM 0.00259066751420171 0.497893183322087 no 1671 0.498966474350217 2401 1908457 SGTC_2165 5727197 32.143 µM 0.00255341920421405 0.497909244505867 no 1672 0.498981334226792 2395 1361712 SGTC_742 0kpi-0133 140 µM 0.00109850139480114 0.498536596228982 no 1673 0.499561761436671 2401 2728852 SGTC_2691 st077356 60.2 µM 0 0.499010265840375 no 1674 0.5 2404 2839272 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.000842103582505121 0.499373378673036 no 1675 0.499664049316167 2410 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2316 5844804 197.44 µM -0.00196062748384175 0.499855683966283 no 1676 0.499217823301701 2408 776813 SGTC_2964 9083345 53.42 µM -0.00220270867225356 0.499960068947769 no 1677 0.499121247089838 2411 17741579 SGTC_2118 5526350 200 µM -0.00224637651258703 0.499978898444003 no 1678 0.499103826185142 2417 743594 SGTC_928 2764-0428 58.7 µM -0.00234425054641859 0.499978898444003 no 1679 0.499064780197765 2427 662578 SGTC_328 k915-0120 63.5 µM -0.00241995386948279 0.499946255303804 no 1680 0.499034579027122 2409 6624543 SGTC_480 am 92016 50 µM -0.00273320824482627 0.499811180572541 no 1681 0.498909609027612 2413 2129 K+ channel blocker. SGTC_2507 purpurin 79.67 µM -0.00425389641385308 0.499155463120473 no 1682 0.498302945982279 2415 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2572 astragaloside iv 100 µM -0.00427919840526651 0.499144552970842 no 1683 0.498292852039999 2432 45006101 An anti-inflammatory agent. SGTC_326 k292-0812 17.5 µM -0.00454312478582869 0.499030748675655 no 1684 0.498187561672578 2415 3579357 SGTC_2686 alizarin 95.37 µM -0.00499836364351331 0.498834451181931 no 1685 0.49800594971289 2418 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_22 0964-0034 14.468 µM -0.00511826623800669 0.49878274962372 no 1686 0.497958116110398 2414 138402 SGTC_1863 st057641 20.1 µM -0.006966764869233 0.497985686920676 no 1687 0.497220685418781 2413 3921635 SGTC_2431 5490079 200 µM -0.00731392920241682 0.497835992321569 no 1688 0.49708219041932 2419 5722345 SGTC_3275 9138069 49.47 µM -0.00764000693806683 0.497695390378773 no 1689 0.496952107860635 2450 17617007 SGTC_3118 9124250 49.47 µM -0.0079451715257336 0.49756380626627 no 1690 0.49683036850094 2445 1504786 SGTC_3047 9092122 49.47 µM -0.00871522752967095 0.497231766539071 no 1691 0.496523171269016 2425 17173831 SGTC_3085 9117376 49.47 µM -0.0100629426127439 0.496650651287967 no 1692 0.495985534479317 2437 16480349 SGTC_527 4476-4215 268 µM -0.0106726937548072 0.496387737675795 no 1693 0.49574229204561 2437 4418754 SGTC_964 1287-0107 19.4 µM -0.0107886183399541 0.496337753275248 no 1694 0.49569604748982 2428 51516812 YPR165W RHO1 SGTC_3182 9108849 49.47 µM -0.0132806068902361 0.495263272035231 no 1695 0.494701960142424 2438 17133045 SGTC_380 3970-0968 6 µM -0.013439947058667 0.495194569747183 no 1696 0.494638398285392 2434 2891601 SGTC_1571 st070080 73.4 µM -0.0138510731151313 0.495017306252668 no 1697 0.494474397989182 2435 4315245 SGTC_1131 3454-3128 32.3 µM -0.0139690559479257 0.494966436270475 no 1698 0.49442733420225 2483 710982 SGTC_2448 5185112 27.17 µM -0.0142731658973335 0.494835315304973 no 1699 0.49430602398159 2448 5718189 SGTC_2826 7992541 19.48 µM -0.0144968846667168 0.4947388563992 no 1700 0.494216782339567 2423 2985066 SGTC_2450 5739737 12.93 µM -0.0146054709033827 0.494692038312051 no 1701 0.494173467284651 2437 2262825 SGTC_423 5-fluorouracil 457 µM -0.0153136856759788 0.494386685957486 no 1702 0.493890962086705 2431 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2565 isoliquiritigenin 100 µM -0.0160937886651761 0.494050342248078 no 1703 0.493579784400855 2485 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_806 3966-4455 5.86 µM -0.0161382835378726 0.494031158277446 no 1704 0.493562035819916 2445 714982 SGTC_567 1080-0542 68.4 µM -0.016225867908437 0.493993396304107 no 1705 0.493527099285939 2439 5950415 SGTC_2380 9035439 200 µM -0.0167887087774337 0.493750728942522 no 1706 0.493302588859692 2511 6462575 SGTC_1318 1280-3875 124 µM -0.0168359580833166 0.493730357632427 no 1707 0.493283741777653 2451 373245 SGTC_1786 berberine 21.6 µM -0.0168514834691646 0.493723663940846 no 1708 0.493277548923371 2436 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3087 9117406 49.47 µM -0.0170560371719187 0.49363547181229 no 1709 0.493195955529909 2485 42546093 SGTC_19 0279-0214 38.434 µM -0.0176950120274002 0.493359983576336 no 1710 0.492941079925784 2444 3566274 YBR002C RER2 SGTC_1306 1185-0270 9.02 µM -0.0179157504328629 0.493264814936456 no 1711 0.492853032001209 2448 1548076 SGTC_2227 7312221 64.1025 µM -0.0182318439489355 0.49312853578608 no 1712 0.492726949528479 2445 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2391 6285546 200 µM -0.0198275016157936 0.49244060361835 no 1713 0.492090489538199 2441 846083 SGTC_568 1193-0097 7.48 µM -0.0201936990361713 0.492282728876523 no 1714 0.491944427151431 2445 3646150 SGTC_2778 tioconazole 65.09 nM -0.020290434827931 0.492241024419431 no 1715 0.491905843059643 2442 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_205 1486-1330 71.903 µM -0.0209727955575395 0.491946849454037 no 1716 0.491633678450836 2431 4118834 SGTC_2950 9072895 21.46 µM -0.0214880560780354 0.491724716548917 no 1717 0.491428165566793 2458 17332245 SGTC_1928 4'-methoxychalcone 40.3 µM -0.0216213895033211 0.491667235864877 no 1718 0.491374985581402 2457 641818 SGTC_2014 4013930 200 µM -0.0221050733338284 0.491458718889085 no 1719 0.491182069765422 2444 64556 SGTC_1778 st046819 58.9 µM -0.0225202823182783 0.491279723403173 no 1720 0.49101646657588 2442 671715 SGTC_919 tnp00227 403.569 nM -0.0229072106546006 0.491112921209194 no 1721 0.490862144317661 2470 1269246 A methoxyflavone. YNL221C POP1 SGTC_332 4112-0506 40.9 µM -0.0231144931319069 0.491023563769836 no 1722 0.490779472463867 2443 2790355 SGTC_2300 7976697 71.57 µM -0.0240587113715887 0.490616526331085 no 1723 0.490402888666707 2460 2236109 SGTC_3046 9092212 49.47 µM -0.0243189473695641 0.490504344438445 no 1724 0.490299099892345 2451 25236637 SGTC_668 1682-0499 62.6 µM -0.0249969872459471 0.490212060229932 no 1725 0.49002868334424 2476 682214 SGTC_2995 9067767 71.4286 µM -0.0255637787103334 0.48996773615671 no 1726 0.489802638511866 2470 11673567 SGTC_1439 4092-1168 46 µM -0.0277452227429686 0.489027427495338 no 1727 0.488932677519539 2462 2886240 SGTC_1241 0364-0022 50.8 µM -0.0284454294099844 0.488725616985212 no 1728 0.488653445707945 2486 4563895 SGTC_522 1273-0010 11.6 µM -0.0286955640448624 0.488617802855874 no 1729 0.488553697145912 2617 5705015 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.029302998578837 0.488355987232199 no 1730 0.488311467705303 2464 442882 SGTC_3033 9090887 49.47 µM -0.0300372396600244 0.48803952232831 no 1731 0.488018676803204 2448 19325384 SGTC_1744 st037937 38.9 µM -0.0306094576850856 0.487792896116974 no 1732 0.487790499771645 2504 1016152 SGTC_1926 methyl fluorone black 53.6 µM -0.0326411456873331 0.486917276084748 no 1733 0.486980378892671 2458 72721 Reacts with homocysteine. SGTC_197 4544-0043 41.561 µM -0.0332204267753285 0.486667627996995 no 1734 0.486749404450199 2476 896523 SGTC_2170 morpholine 200 µM -0.0340145038499416 0.486325419528641 no 1735 0.486432792497071 2490 121171 Reacts with secondary amines. SGTC_1550 gossypolone 36.6 µM -0.0343183087689319 0.486194497083636 no 1736 0.486311662591088 2480 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2973 9094665 17.96 µM -0.0356415660477505 0.485624266850386 no 1737 0.485784082224561 2491 25237061 YIL048W NEO1 SGTC_275 trichlorophene 5.69 µM -0.0357631585031963 0.485571870564743 no 1738 0.485735604759094 2522 62616 SGTC_3232 9132874 49.47 µM -0.0367319684285143 0.485154402637118 no 1739 0.485349359357858 2477 3784940 SGTC_1809 st050081 57.6 µM -0.0378635921798851 0.484666797567183 no 1740 0.484898220726124 2522 5036894 SGTC_770 0389-1121 67.2 µM -0.0378808455195235 0.484659363455659 no 1741 0.484891342573917 2596 6753108 SGTC_2100 5377183 190 µM -0.0382279668097705 0.484509797120503 no 1742 0.484752961449259 2521 2844202 SGTC_3157 9099274 49.47 µM -0.0385063705970978 0.484389841102279 no 1743 0.484641976125295 2479 17217662 SGTC_2761 levamisole 97.89 µM -0.0385681176340937 0.48436323630792 no 1744 0.484617360906607 2487 26879 An alkaline phosphatase inhibitor. SGTC_1835 st008666 49.2 µM -0.0387142549049856 0.484300270778054 no 1745 0.484559104079633 2484 690455 SGTC_2413 inermin 26.06 µM -0.0387855911674637 0.484269534575222 no 1746 0.484530666386829 2496 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2698 st077697 67.5 µM -0.0392141070444052 0.484084904631489 no 1747 0.484359843246403 2502 3154499 SGTC_1412 3909-8563 178 µM -0.0414221869542842 0.48313358837943 no 1748 0.483479662671394 2484 23767530 SGTC_2526 patulin 37.61 µM -0.0425447013654612 0.482650007298015 no 1749 0.483032238726559 2531 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2395 5646831 180.19 µM -0.0429906755259945 0.482457887930542 no 1750 0.482854483417697 2525 6808628 SGTC_2878 9043973 25.97 µM -0.0435314785522647 0.482224923096391 no 1751 0.482638936022889 2608 6465167 SGTC_2595 hexamethylquercetagetin 100 µM -0.0453839586364615 0.481426966070559 no 1752 0.481900633483136 2528 386331 SGTC_1746 st038117 42 µM -0.0455387139386902 0.481360308444841 no 1753 0.481838958815501 2536 2898218 SGTC_1745 st081495 74 µM -0.0455892186284338 0.481338554713518 no 1754 0.481818831263408 2510 13842402 YBL026W LSM2 SGTC_3189 9110682 49.47 µM -0.0458022789442024 0.481246784504512 no 1755 0.481733921192048 2514 17122418 SGTC_2303 7774051 200 µM -0.0460211776107695 0.481152500612272 no 1756 0.481646685249219 2527 2953184 SGTC_3050 9093513 49.47 µM -0.0463151617656196 0.481025877606709 no 1757 0.48152952746796 2497 25236664 SGTC_1301 naphtanilide LB 4.81 µM -0.0465823721095006 0.480910788108973 no 1758 0.481423040898069 2503 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2980 9014342 25.29 µM -0.046643613394116 0.480884411252483 no 1759 0.481398635688208 2616 2996599 SGTC_970 1315-0089 19.5 µM -0.0471176381299601 0.48068024981789 no 1760 0.481209734877434 2484 6811083 YLR033W RSC58 SGTC_1025 k007-0731 70 µM -0.047821974497645 0.480376903033498 no 1761 0.480929061736723 2492 6256118 SGTC_3096 9117468 49.47 µM -0.0489548578761618 0.479889011589418 no 1762 0.480477635485336 2486 41316311 SGTC_283 0987-0079 11.7 µM -0.0491024991136628 0.479825430110798 no 1763 0.480418805903535 2476 411556 SGTC_2248 tofa 1.1 µM -0.0491784319965529 0.479792729927876 no 1764 0.480388549619364 2486 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2032 5185112 25.99 µM -0.0495660765275703 0.47962579453297 no 1765 0.480234090198559 2519 5718189 SGTC_1767 st044992 70.3 µM -0.0503627205746099 0.479282738674534 no 1766 0.479916671669862 2519 9600693 SGTC_861 0443-0273 110 µM -0.0504614465280772 0.47924022574855 no 1767 0.479877335728389 2567 6149169 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0530996620211041 0.478104258273719 no 1768 0.478826250371363 2566 5282362 SGTC_626 0214-0009 33 µM -0.0561143299921484 0.476806415502485 no 1769 0.47762536412161 2565 3437874 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0566463321615577 0.476577408732834 no 1770 0.477413463022679 2494 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2405 ticlatone 3.52 µM -0.0570753460705123 0.476392740136552 no 1771 0.477242587693437 2475 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1122 capsaicin 818.572 nM -0.0573725647776529 0.476264805620082 no 1772 0.477124208564851 2612 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3076 9116187 49.47 µM -0.0577760357565666 0.476091139901784 no 1773 0.476963513490391 2542 27241210 SGTC_3020 9089140 49.47 µM -0.0578856367476464 0.476043965210386 no 1774 0.476919862076179 2542 17217859 SGTC_2247 cerulenin 830 nM -0.0580728679027294 0.475963377556011 no 1775 0.476845293093019 2674 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2896 9052656 71.43 µM -0.0587633316727646 0.475666198063066 no 1776 0.47657030752617 2507 6469436 SGTC_593 1203-0218 61.7 µM -0.0591250998260196 0.475510496407234 no 1777 0.476426233419464 2541 3666956 SGTC_1837 st055472 66.5 µM -0.0597130853656893 0.475257440876595 no 1778 0.476192074859316 2634 676091 SGTC_2584 androsterone 48.74 µM -0.0598500811026659 0.475198482473972 no 1779 0.476137519041615 2515 2754130 A steroid. SGTC_846 0335-0850 148 µM -0.0606685796159724 0.47484623933334 no 1780 0.475811577701793 2515 6819598 SGTC_1777 st045864 34.765 µM -0.0610006443763698 0.474703339919016 no 1781 0.47567934793743 2520 4691462 SGTC_1124 fisetin 1.16336 µM -0.0611862304274113 0.474623476980203 no 1782 0.47560544785652 2591 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0623535975515229 0.474121149322939 no 1783 0.47514062340075 2541 551469 SGTC_2279 7948423 32.93 µM -0.062998487132739 0.473843665632666 no 1784 0.47488385451152 2501 1247112 SGTC_52 0329-0193 875 nM -0.0634477114153436 0.473650380480139 no 1785 0.474704997770282 2702 3739292 SGTC_2528 xanthyletin 44.79 µM -0.0636947574101561 0.47354408805928 no 1786 0.474606639626406 2542 65188 An natural product with antifungal activity of unknown mechanism. SGTC_859 0439-0102 54.6 µM -0.0640637355396881 0.473385337412066 no 1787 0.474459738675721 2514 610143 SGTC_899 1083-0020 478 µM -0.0647022444687735 0.473110632740626 no 1788 0.474205537870854 2654 767123 SGTC_3143 9086658 49.47 µM -0.0661127414685055 0.472503842392335 no 1789 0.473644033410645 2598 25236626 SGTC_98 0074-0023 107.663 µM -0.0674762043923444 0.471917346556486 no 1790 0.47310130249333 2589 3563821 SGTC_2205 7238770 200 µM -0.0678608161236688 0.471751916138605 no 1791 0.472948215509383 2594 279867 SGTC_3164 9100705 49.47 µM -0.0679156561791235 0.471728328556321 no 1792 0.4729263878504 2605 17174235 SGTC_2365 9042475 200 µM -0.0679938740359912 0.471694685980491 no 1793 0.472895255405752 2574 6464479 SGTC_1876 myriocin 605 nM -0.0684062918000278 0.471517302774497 no 1794 0.4727311067163 2556 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1431 4049-0260 9.09 µM -0.0688109489860904 0.471343262928188 no 1795 0.472570051358508 2513 3854841 SGTC_1092 toremifene 6.32 µM -0.0691555894370253 0.47119504011758 no 1796 0.47243288646305 2521 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2156 5649887 115 µM -0.0697721572620921 0.470929876871615 no 1797 0.47218750422034 2618 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3191 9110352 49.47 µM -0.0699490718973516 0.470853794739047 no 1798 0.472117097512367 2530 17122424 SGTC_3340 9146634 11.102 µM -0.0701669172185407 0.470760111828231 no 1799 0.47203040281869 2563 4907387 SGTC_2522 biochanin a 4.94 µM -0.0702996121825558 0.470703048046809 no 1800 0.471977595589343 2566 5280373 A possible chelator. SGTC_2488 5268135 45.7 µM -0.0712319402786985 0.470302129235995 no 1801 0.471606580653386 2601 1270356 YLR208W SEC13 SGTC_1063 disulfiram 1.84 µM -0.0715378179313164 0.470170602566856 no 1802 0.471484863643845 2531 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_902 1120-0002 2.07 µM -0.0718162543540776 0.470050878390956 no 1803 0.471374068558901 2558 3280475 SGTC_352 k048-0007 5.11 µM -0.0721385035355907 0.469912318657957 no 1804 0.471245842320296 2525 6811911 SGTC_1127 asiatic acid 681.4 nM -0.0722382571569102 0.469869427633804 no 1805 0.471206149939716 2539 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2378 9074213 121.43 µM -0.0732251139019117 0.469445128155069 no 1806 0.470813491012863 2544 657714 SGTC_336 4111-0029 111 µM -0.0739631818315224 0.469127818185079 no 1807 0.470519840813516 2582 3131175 SGTC_2585 alliin 100 µM -0.0739951643737479 0.469114068700733 no 1808 0.470507116492456 2595 87310 A garlic compound which reacts with lipids. SGTC_1338 1486-1223 76 µM -0.0741137659698583 0.469063081493743 no 1809 0.470459930863323 2606 3444526 SGTC_2695 st077686 51.995 µM -0.0746341708158042 0.468839363787886 no 1810 0.470252892776523 2574 2876092 SGTC_1562 morin hydrate 59.1 µM -0.0758386089377042 0.468321623732387 no 1811 0.469773749533918 2650 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2046 4110841 106 µM -0.0758958821653787 0.46829700557665 no 1812 0.469750966484089 2555 44119630 YMR134W ERG29 SGTC_3202 9113761 49.47 µM -0.0765320504853765 0.468023565030367 no 1813 0.469497908069923 2692 4798415 SGTC_2420 aureobasidin a 50 nM -0.0775171186922735 0.46760018867734 no 1814 0.46910608675067 2784 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3014 9081533 49.47 µM -0.0787966203631497 0.46705032139068 no 1815 0.468597196125153 2577 21367265 SGTC_2606 farnesol 9.78 µM -0.0789517184538067 0.466983672063137 no 1816 0.468535513107142 2585 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2443 5493264 126.67 µM -0.0791157335829394 0.46691319187983 no 1817 0.468470284575496 2618 5340055 SGTC_3307 9126885 69.2785 µM -0.0796144053420582 0.466698910242834 no 1818 0.468271968890179 2544 24824909 SGTC_2703 st077852 53.4 µM -0.0804795563312887 0.466327173664122 no 1819 0.467927927585482 2638 6281836 SGTC_1653 st012112 65 µM -0.0805309357578909 0.466305097961928 no 1820 0.46790749647524 2622 720429 SGTC_1442 4112-3290 3 µM -0.0814652194317529 0.465903691464928 no 1821 0.467535991893252 2546 704353 SGTC_1366 1683-0113 21.9 µM -0.0814728635758907 0.465900407370309 no 1822 0.467532952424502 2548 708623 SGTC_2523 spermine 47.74 µM -0.0815317352985118 0.465875114844539 no 1823 0.46750954388157 2569 1103 A DNA binding polyamine. SGTC_2865 9030313 51.95 µM -0.083040230517931 0.465227080984458 no 1824 0.466909775367656 2553 42562754 SGTC_1505 k297-0037 20.6 µM -0.0832219488242845 0.46514902287858 no 1825 0.466837530318767 2576 4089396 SGTC_553 k007-0256 45.7 µM -0.0840704049124139 0.464784581658807 no 1826 0.466500227389482 2600 6287000 SGTC_1019 4262-0212 3.4 µM -0.0854205001260313 0.464204730115694 no 1827 0.465963547990906 2556 4677213 SGTC_3225 9130819 49.47 µM -0.0879478519152296 0.463119464692727 no 1828 0.464959061797569 2570 4547121 SGTC_257 daunorubicin 18.5 µM -0.0881107695246951 0.463049515874753 no 1829 0.464894318415007 2694 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2737 bleomycin 30.5 nM -0.0884247691254539 0.46291470309661 no 1830 0.464769537742326 2576 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3248 9135562 49.47 µM -0.0884326196359223 0.462911332608218 no 1831 0.464766418063028 2589 17650701 SGTC_1031 k035-0009 16 µM -0.0889240048373168 0.462700369710387 no 1832 0.464571153010429 2696 5180959 SGTC_1490 4089-0339 670 nM -0.0902836388368123 0.46211670261313 no 1833 0.464030910683518 2566 742542 SGTC_1067 clotrimazole 1.36 µM -0.0903105152024411 0.462105165877415 no 1834 0.464020232187675 2582 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2875 9039966 71.43 µM -0.0903572512650285 0.462085104401501 no 1835 0.464001663114835 2664 6463691 SGTC_496 calpeptin 138 µM -0.092566340061621 0.461136962965278 no 1836 0.463124042818853 2653 73364 A calpain inhibitor. SGTC_982 1491-0518 27.5 µM -0.0937247234029256 0.460639872491787 no 1837 0.462663915143044 2632 3091256 SGTC_3194 9111903 49.47 µM -0.0939751845960993 0.460532401560238 no 1838 0.462564434652667 2690 17087251 SGTC_1806 st050005 60.3 µM -0.0939928318344558 0.460524829377441 no 1839 0.462557425447746 2576 5194765 SGTC_2846 9008642 19.48 µM -0.0951093021046064 0.460045796839033 no 1840 0.46211400478074 2699 2992898 SGTC_1040 k898-0338 155 µM -0.0951787707977876 0.460015992522866 no 1841 0.462086415937349 2572 20969351 SGTC_2536 dehydroabietamide 32.04 µM -0.0955886582022894 0.459840142148627 no 1842 0.461923636696508 2653 3983547 SGTC_760 0568-0725 82.9 µM -0.0958031473571511 0.459748124889033 no 1843 0.461838458815376 2672 3916171 SGTC_444 curcumin 90.4 µM -0.0962136624743491 0.459572017217209 no 1844 0.461675440035612 2667 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1924 st058459 75.1 µM -0.0969990802087739 0.459235101483251 no 1845 0.46136356244662 2570 688683 SGTC_2289 7946404 165.07 µM -0.0973745892303585 0.459074032055951 no 1846 0.461214461836021 2605 1246120 YPR165W RHO1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0978776300838113 0.45885827013697 no 1847 0.461014731644356 2575 2724278 An inhibitor of dopamine biosynthesis. SGTC_3083 9117465 49.47 µM -0.0989552388071041 0.458396108136578 no 1848 0.460586904929499 2678 16420915 SGTC_629 3448-6466 76.7 µM -0.0999485126955238 0.45797016523043 no 1849 0.460192600792252 2594 573744 SGTC_2263 7948595 193.29 µM -0.100262547083273 0.457835508747351 no 1850 0.460067945358735 2583 2971371 SGTC_2874 9043904 71.43 µM -0.101105766813633 0.457473964040271 no 1851 0.459733250126027 2663 4463428 SGTC_1736 st036774 51 µM -0.101557140908323 0.457280444211802 no 1852 0.459554100044192 2827 1272247 SGTC_544 k015-0020 52.4 µM -0.101563384592752 0.457277767397287 no 1853 0.459551621987441 2627 3008304 SGTC_3179 9107801 49.47 µM -0.102442722804467 0.456900793817638 no 1854 0.459202637066135 2610 4818259 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.102676176735384 0.456800718276242 no 1855 0.45910999095262 2586 2724 A muscle relaxant with antifungal properties. SGTC_3124 9127567 49.47 µM -0.103276583112209 0.456543352500945 no 1856 0.458871730097071 2631 17592030 SGTC_1198 1612-1005 86.7 µM -0.104830926367058 0.455877164112555 no 1857 0.458254984777492 2748 6998509 SGTC_2745 rifampicin 24.3 µM -0.106118001782745 0.455325619971297 no 1858 0.457744364217068 2672 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2181 6316240 54.2555 µM -0.106310669804343 0.455243064267943 no 1859 0.457667933143529 2661 12779990 SGTC_759 3486-0358 89.3 µM -0.106768258900573 0.455047001134802 no 1860 0.45748641461373 2590 875103 SGTC_1259 0671-0132 43 µM -0.106825886348895 0.455022310285779 no 1861 0.457463555322642 2621 X1259 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.107123895570239 0.454894629102476 no 1862 0.457345345160001 2645 390807 SGTC_1298 1079-1278 263 µM -0.107339672667708 0.454802182940943 no 1863 0.457259756049969 2620 2840950 SGTC_2927 9011802 47.9 µM -0.10743228934958 0.454762503591831 no 1864 0.457223019768331 2682 43912568 SGTC_3147 9097027 49.47 µM -0.107454801612624 0.454752858832246 no 1865 0.457214090364843 2637 25236841 SGTC_1690 st023502 41.2 µM -0.108676046483447 0.45422969019732 no 1866 0.456729720721642 2619 24207482 SGTC_675 1309-0189 238 µM -0.109716207124027 0.453784158744367 no 1867 0.456317223294922 2643 4246530 SGTC_644 1498-1197 63.3 µM -0.1100718353246 0.453631846018821 no 1868 0.456176202280415 2685 6741615 SGTC_474 dl-dihydrosphingosine 5 µM -0.110747488234923 0.453342488064656 no 1869 0.455908293701405 2763 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1629 st005085 44.9 µM -0.110890157394404 0.453281391133171 no 1870 0.455851725362807 2604 24207091 SGTC_969 1313-0238 134 µM -0.110963815181218 0.453249848205249 no 1871 0.455822520391851 2625 5212874 SGTC_1747 st037496 66.6 µM -0.111346673079252 0.453085899363838 no 1872 0.455670722858796 2614 723305 SGTC_835 0312-0010 67.2 µM -0.113162332299303 0.452308500332995 no 1873 0.454950929130941 2590 1626196 SGTC_1112 tnp00069 1.16933 µM -0.113403850923408 0.452205104580941 no 1874 0.454855193406634 2739 145826 SGTC_1416 3966-0321 25.3 µM -0.113642550504298 0.452102918865111 no 1875 0.454760577701032 2638 582530 YLR208W SEC13 SGTC_343 4130-2827 29.8 µM -0.114938365701799 0.451548244464684 no 1876 0.454246987580964 2634 1118244 SGTC_2328 6201408 200 µM -0.115060895951028 0.451495800202396 no 1877 0.454198427251053 2684 2890418 SGTC_3197 9113331 49.47 µM -0.115574751647082 0.451275873676874 no 1878 0.453994787025883 2733 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3293 9120939 62.045 µM -0.117234153860419 0.450565763983834 no 1879 0.453337251325754 2718 934087 SGTC_1452 4194-0072 190 µM -0.117662421412058 0.450382520605034 no 1880 0.453167571627819 2774 1343545 SGTC_1723 st034307 2.5525 µM -0.117736694843826 0.450350742212988 no 1881 0.453138145346988 2678 867466 SGTC_304 1310-0298 97 µM -0.118069894299689 0.450208184483592 no 1882 0.453006138717328 2620 1550234 SGTC_2069 5228469 200 µM -0.118134571568087 0.450180513380086 no 1883 0.452980515542744 2722 2835210 SGTC_325 2810-4341 181 µM -0.118431084507535 0.450053658307397 no 1884 0.452863048605645 2727 774970 SGTC_2620 irigenin 100 µM -0.11844502019133 0.450047696425989 no 1885 0.452857527929125 2702 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_497 capsazepine 133 µM -0.12038979018679 0.449215807653083 no 1886 0.45208718941427 2633 2733484 A calcium channel blocker. SGTC_2882 9058044 58.44 µM -0.121399416922534 0.448784020631821 no 1887 0.45168733934688 2699 18076804 SGTC_2815 7968870 71.43 µM -0.12164774297558 0.448677828314109 no 1888 0.451589000406515 2636 2977326 YHR190W ERG9 SGTC_2930 9013230 14.89 µM -0.121845222454034 0.44859338227395 no 1889 0.451510799203242 2691 2995857 SGTC_1691 st019933 84.6 µM -0.122597222238874 0.448271833991231 no 1890 0.451213027091629 2608 6176082 SGTC_3056 9094900 49.47 µM -0.12305650033463 0.448075467547454 no 1891 0.451031178552338 2682 25236784 SGTC_665 3914-0008 307 µM -0.123442115214478 0.447910605971234 no 1892 0.450878504478085 2623 1069549 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.124003341244933 0.44767068160459 no 1893 0.450656314776674 2622 17037758 SGTC_1720 st037298 9.481 µM -0.124624903971406 0.447404985621009 no 1894 0.450410255791625 2703 597396 SGTC_2383 9036125 200 µM -0.125136791282688 0.447186189697018 no 1895 0.450207628488049 2623 79580 SGTC_173 1273-0061 2.693 µM -0.125521717182301 0.4470216714555 no 1896 0.450055266590339 2725 2847414 YPL266W DIM1 SGTC_2521 angolensin 13.4 µM -0.126606235846963 0.446558194725324 no 1897 0.44962603058529 2763 821428 A flavenoid. SGTC_608 k048-0125 159 µM -0.127428066353253 0.446207028219179 no 1898 0.44930080178425 2668 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2710 st078562 53.7235 µM -0.127911100635898 0.446000648318278 no 1899 0.449109663087473 2610 17250908 SGTC_2925 9010536 32.5 µM -0.128016857201103 0.445955465008829 no 1900 0.449067816344207 2714 2994177 SGTC_3062 9077494 49.47 µM -0.128376062466462 0.44580200382099 no 1901 0.448925686890199 2722 16459633 SGTC_2821 7996764 71.43 µM -0.128842362460296 0.44560280128618 no 1902 0.448741192236889 2762 2987135 SGTC_1671 st016596 74.5 µM -0.12970408622521 0.445234710587173 no 1903 0.448400274770454 2677 2829167 SGTC_867 0518-0118 155 µM -0.130260602902463 0.44499701607544 no 1904 0.448180124384017 2661 6848158 SGTC_916 4466-0038 42 nM -0.130676140902592 0.444819548027486 no 1905 0.448015753637122 2684 5722064 YGL116W CDC20 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.131936491312449 0.444281345125859 no 1906 0.447517262509164 2753 5377381 SGTC_1376 2910-0861 41.3 µM -0.132073305461711 0.444222928035074 no 1907 0.447463155039402 2647 1112859 SGTC_247 mechlorethamine 29.705 µM -0.132108624900643 0.444207847489927 no 1908 0.447449187012214 2628 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2096 5468907 200 µM -0.132960434244812 0.443844170042726 no 1909 0.447112335753652 2772 759785 SGTC_1803 st050068 52.4 µM -0.133334505037552 0.443684476562833 no 1910 0.4469644200707 2636 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_762 1165-0429 115 µM -0.134125036703355 0.443347023090851 no 1911 0.44665185104432 2740 5967793 SGTC_3107 9121808 49.47 µM -0.13720304062059 0.442033512195675 no 1912 0.445435153786912 2636 662681 SGTC_2854 9024559 71.43 µM -0.137655601465951 0.441840439242452 no 1913 0.445256305074169 2734 3163529 SGTC_161 4065-0411 162.148 µM -0.137862186927983 0.441752309683228 no 1914 0.445174667722761 2767 1906281 YLR208W SEC13 SGTC_100 0086-0128 49.5915 µM -0.138693543870822 0.441397681195483 no 1915 0.444846160018252 2692 93297 SGTC_215 1287-0124 461.5 µM -0.139145836777188 0.441204768196284 no 1916 0.44466745399793 2723 5560863 SGTC_577 r071-0003 38.6 µM -0.140472755543414 0.440638888444803 no 1917 0.444143238481022 2661 4568517 YMR134W ERG29 SGTC_937 3122-0005 46.7 µM -0.141026443733478 0.440402797527521 no 1918 0.443924526015605 2788 759535 SGTC_1236 0330-0013 258 µM -0.141494986112512 0.440203029064117 no 1919 0.44373946034886 2704 4617066 SGTC_3097 9117246 49.47 µM -0.142452286339076 0.439794920410248 no 1920 0.443361382459344 2639 16423892 SGTC_941 3237-0776 460 µM -0.142769314420087 0.439659781586705 no 1921 0.443236186160525 2800 760008 SGTC_609 0986-0026 86.3 µM -0.143543215173501 0.439329922271082 no 1922 0.4429305919159 2666 2848610 SGTC_821 1114-0266 29.2 µM -0.14408103186335 0.439100713736697 no 1923 0.442718241403772 2732 3123235 SGTC_793 0488-0545 106 µM -0.144268119473629 0.43902098488958 no 1924 0.442644375944348 2650 292548 SGTC_1246 0422-0085 105 µM -0.144550637990974 0.438900592105408 no 1925 0.442532836473625 2731 264295 SGTC_1484 3473-2379 286 µM -0.144605483375647 0.438877220881389 no 1926 0.44251118381824 2664 671917 SGTC_615 k087-0205 167 µM -0.14551376019505 0.438490208586074 no 1927 0.442152626157665 2675 9642773 SGTC_890 0929-0006 47.2 µM -0.146111404089009 0.438235587512209 no 1928 0.44191672193672 2667 1378169 SGTC_2474 5321570 43.32 µM -0.14784161829014 0.437498589050882 no 1929 0.441233881785586 2824 2841384 SGTC_2414 st077232 92.9 µM -0.148052687583032 0.437408697197411 no 1930 0.441150593845081 2638 729801 SGTC_1193 1488-0126 41.5 µM -0.150629278213672 0.436311620291788 no 1931 0.440134082112859 2691 1384710 SGTC_1567 st069303 68.4 µM -0.151076011393515 0.436121457022943 no 1932 0.439957877709877 2778 5581319 SGTC_3250 9135583 49.47 µM -0.152473035997734 0.435526873672982 no 1933 0.439406927960737 2818 7699353 SGTC_1985 st071382 65.5 µM -0.152802665104334 0.435386602439475 no 1934 0.439276947984628 2684 6123237 SGTC_787 4152-0075 138 µM -0.153935165012938 0.434904737515306 no 1935 0.438830428436923 2711 9566539 SGTC_3336 9143619 71.43 µM -0.15446374278558 0.434679867152324 no 1936 0.4386220485754 2664 45595730 SGTC_2907 7721985 69.9 µM -0.154730220729783 0.434566508696792 no 1937 0.438517002104764 2723 3267881 SGTC_1974 st069448 26.9 µM -0.1551206632912 0.434400425997657 no 1938 0.438363096203805 2792 6323587 YNR016C ACC1 SGTC_360 0957-0399 1.01 µM -0.156168780306674 0.4339546454004 no 1939 0.43794999223693 2811 6752301 YPR165W RHO1 SGTC_2116 5511452 16.8835 µM -0.156877912703117 0.43365308787362 no 1940 0.437670533705859 2805 870744 SGTC_411 enrofloxacin 100 µM -0.15921398930965 0.432659948742844 no 1941 0.43675014128724 2831 71188 A bacterial gyrase inhibitor. SGTC_1842 st055362 61.2 µM -0.159376229714546 0.432590990999652 no 1942 0.436686232733368 2697 676032 SGTC_1706 st031321 9.9705 µM -0.159690474377429 0.432457432068346 no 1943 0.436562452475295 2798 6103185 SGTC_1280 0880-0253 10.1 µM -0.159734122708414 0.432438881450236 no 1944 0.436545259988008 2727 6836607 SGTC_2702 st077768 96.8 µM -0.159986512915563 0.432331618085946 no 1945 0.436445849250148 2766 6484119 SGTC_35 0133-0054 64.071 µM -0.160191202034367 0.432244630878718 no 1946 0.43636522982894 2717 99677 SGTC_2982 9019404 25.97 µM -0.161022528035228 0.43189137414989 no 1947 0.436037828680204 2715 22333232 SGTC_582 0987-0078 156 µM -0.161656892162777 0.431621849368784 no 1948 0.435788026500692 2703 1625765 SGTC_2963 9082507 9 µM -0.163993938231244 0.430629174997886 no 1949 0.434867957898987 2831 16459611 SGTC_2288 7946289 167.31 µM -0.164124796557895 0.430573605033029 no 1950 0.434816450833606 2824 1246052 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.164509746738063 0.430410141041166 no 1951 0.434664937246975 2676 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1783 st039459 87.517 µM -0.164560444716815 0.430388613704482 no 1952 0.434644983606417 2931 729761 SGTC_3059 1327-0034 3 µM -0.165370609488396 0.430044630275147 no 1953 0.434326142692382 2726 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3089 9117425 49.47 µM -0.166792995635398 0.429440835698748 no 1954 0.433766465078874 2775 9401657 SGTC_2379 9035213 200 µM -0.167005659988021 0.429350575075613 no 1955 0.433682797723191 2765 646551 SGTC_524 r073-0010 27.8 µM -0.170391656805028 0.427913965189896 no 1956 0.432351066552856 2686 2772106 SGTC_204 PMA1.184 62.41 µM -0.171670855570412 0.427371474581883 no 1957 0.431848149751437 2671 2252213 YGL008C PMA1 SGTC_2643 anethole 100 µM -0.171694518627507 0.427361440695007 no 1958 0.431838847661923 2731 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3246 9135460 32.98 µM -0.173111488872173 0.426760686237209 no 1959 0.431281897239127 2789 41446951 SGTC_1972 st070201 17.4 µM -0.173773621162108 0.426480019415136 no 1960 0.431021688107829 2820 2829099 SGTC_817 1391-0715 46 µM -0.174927976784554 0.425990796446398 no 1961 0.430568113452193 2783 1353946 SGTC_2475 5812728 15.03 µM -0.174998697302409 0.42596082835331 no 1962 0.430540328596226 2693 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2742 clothiapine 36.27 µM -0.175127503908978 0.425906247154132 no 1963 0.430489723614369 2739 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_89 0302-0250 142.109 µM -0.17550518636444 0.425746214160988 no 1964 0.430341347950342 2684 4203518 YLR208W SEC13 SGTC_1319 1306-0155 43.7 µM -0.175541238586461 0.425730938620476 no 1965 0.430327185051799 2717 3122360 SGTC_1495 4469-0029 237 µM -0.175640551539804 0.425688859709015 no 1966 0.430288171019097 2705 793680 SGTC_2206 7254556 146.969 µM -0.1761428824247 0.425476035022175 no 1967 0.430090846131813 2767 4398905 SGTC_986 1493-0483 84 µM -0.176286761517338 0.425415081145375 no 1968 0.430034330970349 2716 40079 SGTC_2502 avocadyne acetate 18.59 µM -0.177252694525163 0.425005913214532 no 1969 0.429654953322046 2672 3952079 SGTC_3271 9137798 49.47 µM -0.178090289955288 0.424651174283683 no 1970 0.429326033814625 2855 6498326 SGTC_2669 eugenol 100 µM -0.179126140524373 0.424212554634213 no 1971 0.428919328390266 2740 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_685 1278-0033 54.9 µM -0.180147194921029 0.423780292108386 no 1972 0.428518506224067 2831 3590572 SGTC_1525 8-methoxypsoralen 92.5 µM -0.180380713099583 0.423681445247692 no 1973 0.428426847345473 2964 4114 Related to psoralen; DNA damaging agent. SGTC_1175 0741-0056 27.6 µM -0.180575018940952 0.423599200396905 no 1974 0.428350582754454 2900 765927 SGTC_1734 st037168 69.4 µM -0.180923742460976 0.423451602716006 no 1975 0.428213716296006 2820 708907 SGTC_1218 1348-1416 30.7 µM -0.181174880182931 0.42334531500192 no 1976 0.428115155505591 2715 6787668 SGTC_1055 3448-0672 86 µM -0.181590152374766 0.423169573749648 no 1977 0.427952188812932 2873 748378 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.182207465934781 0.422908357794565 no 1978 0.427709957051709 2847 688662 SGTC_1513 0337-0559 19 µM -0.183463777677402 0.422376854832419 no 1979 0.427217068794333 2747 775073 SGTC_2453 5731132 22.18 µM -0.183574453325701 0.422330038471718 no 1980 0.4271736528971 2853 1362040 SGTC_233 rapamycin 362 pM -0.1841226768909 0.422098153314592 no 1981 0.426958608506077 2777 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_308 4092-1169 104 µM -0.184133171129724 0.422093714771424 no 1982 0.426954492281643 2747 2268590 YDL196W YDL196W SGTC_1012 4112-3522 18 µM -0.184246583906963 0.42204574741621 no 1983 0.426910008148375 2849 3112398 SGTC_646 4092-0839 27.3 µM -0.184662780132493 0.42186972926051 no 1984 0.426746770592148 2859 877796 SGTC_1685 st024049 53.0905 µM -0.186130648386175 0.421249061656157 no 1985 0.426171153960544 2821 1941139 SGTC_1754 st042065 16.137 µM -0.187073129893673 0.42085064954136 no 1986 0.425801647731975 2780 1126236 YIL048W NEO1 SGTC_2272 7805186 180 µM -0.187150097610189 0.420818116805443 no 1987 0.425771474892745 2724 2956062 YPR165W RHO1 SGTC_2935 9038016 29.96 µM -0.187266854520192 0.42076876699449 no 1988 0.425725704746924 2827 6463195 SGTC_1272 0839-0021 27 µM -0.187579394677206 0.420636671326531 no 1989 0.425603190084949 2823 5027250 SGTC_359 0081-0058 15.9 µM -0.18914178420039 0.419976458824952 no 1990 0.424990846715226 3126 3494159 SGTC_1503 4585-0012 61.3 µM -0.189246878861847 0.419932057467591 no 1991 0.424949663709021 2921 2922052 SGTC_3073 9114972 49.47 µM -0.190657574423323 0.419336152730841 no 1992 0.424396939792305 2843 41905075 SGTC_1159 4092-0538 61.2 µM -0.192698638569631 0.418474296013666 no 1993 0.42359749486777 2759 717301 SGTC_340 k038-0059 454 µM -0.192979455823724 0.418355749060512 no 1994 0.423487528768368 2745 23733424 SGTC_1822 st052468 42 µM -0.193954452595193 0.417944211986709 no 1995 0.423105773075264 2785 2873678 SGTC_1961 st076550 68.7 µM -0.195828551070603 0.417153425103856 no 1996 0.422372181096412 2881 1579337 SGTC_2683 piperine 63.03 µM -0.196120132261849 0.4170304207408 no 1997 0.422258069488271 2773 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_398 bronopol 33.3 µM -0.196476993224163 0.416879888971725 no 1998 0.422118419229772 2725 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_160 3453-0671 289.699 µM -0.196479868933069 0.416878675984196 no 1999 0.422117293919495 2786 5322268 SGTC_1799 st045822 46.1415 µM -0.196888092757854 0.416706493291385 no 2000 0.421957555950318 2872 3674992 SGTC_1607 st000305 50.6 µM -0.197721580238173 0.41635499041095 no 2001 0.421631452220237 2907 5457690 SGTC_85 0868-0259 160.055 µM -0.197800966747097 0.416321514584131 no 2002 0.421600394881058 2822 83173 SGTC_2719 novobiocin 32.65 µM -0.197936548648589 0.416264343600241 no 2003 0.421547354085753 2857 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2261 9010538 184.68 µM -0.200702214753545 0.415098530141439 no 2004 0.420465713916116 2894 6457250 SGTC_1044 1222-0021 1.78 µM -0.202459039608656 0.414358361741521 no 2005 0.41977893847638 2881 4306703 SGTC_1221 2958-7315 257 µM -0.203671009947334 0.413847923210306 no 2006 0.419305299016424 2869 4562705 SGTC_3332 9141069 11.198 µM -0.203910028011588 0.413747274508439 no 2007 0.419211904250115 2745 17332883 SGTC_153 4077-0274 519.67 µM -0.203919925612482 0.413743106825574 no 2008 0.419208036924542 3020 3121976 SGTC_2825 7998094 58.44 µM -0.204145744388411 0.413648021671405 no 2009 0.419119804054742 2847 2987815 SGTC_3080 9117754 49.47 µM -0.204314701478503 0.41357688248822 no 2010 0.419053791083837 2968 9550191 SGTC_1249 0481-0015 10.2 µM -0.204348953865307 0.413562460906972 no 2011 0.419040408662987 2750 4227577 SGTC_1565 sinapyl alcohol 95.1 µM -0.204686061299416 0.413420531846793 no 2012 0.41890870565714 2845 5280507 A phenol propionate derived from cinnamic acid. SGTC_44 0929-0055 61.211 µM -0.204818628273779 0.413364721562475 no 2013 0.418856916143502 2777 1379590 SGTC_2881 9058953 51.95 µM -0.2051184681432 0.413238496367782 no 2014 0.418739783854197 2740 17122249 SGTC_404 fumagillin 50 µM -0.2063047372854 0.412739194341302 no 2015 0.418276439156099 2809 12015870 A methionine aminopeptidase binder. SGTC_994 3910-0338 138 µM -0.208453323123803 0.411835212001375 no 2016 0.417437512397355 2945 3479481 SGTC_433 pimozide 108 µM -0.209562324559728 0.411368800488402 no 2017 0.417004643647161 2737 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_952 1185-0122 232 µM -0.209943762357523 0.41120840852504 no 2018 0.416855782930329 2736 678600 SGTC_1244 0416-0015 52.5 µM -0.210119527005474 0.411134505695958 no 2019 0.416787192660031 2805 96201 SGTC_2831 7999036 19.48 µM -0.211197708558604 0.41068123751962 no 2020 0.416366499367109 3073 2988270 SGTC_1612 st002233 45.4 µM -0.212061119131966 0.410318345151178 no 2021 0.416029676133981 2772 1035021 SGTC_627 1391-0720 175 µM -0.212222904358295 0.410250355182846 no 2022 0.415966569301657 2868 997839 SGTC_2302 7771753 200 µM -0.212707691942042 0.410046640179269 no 2023 0.415777483378934 2858 2203047 SGTC_458 nppb 133 µM -0.212773916439654 0.410018813536832 no 2024 0.415751654774138 2955 4549 A chloride channel blocker. SGTC_2087 5276107 200 µM -0.213237385924136 0.40982408258812 no 2025 0.415570904514005 2772 144405 SGTC_135 0933-0004 26.348 µM -0.213928340174604 0.409533813138017 no 2026 0.415301469765091 2891 21230617 YGL099W LSG1 SGTC_2221 6807166 181.081 µM -0.21549504033064 0.408875827291767 no 2027 0.414690689239576 2849 674925 SGTC_280 3448-3607 3.04 µM -0.21603076683397 0.408650890617914 no 2028 0.41448188264975 2875 626179 SGTC_329 k048-0121 21.3 µM -0.216258795661533 0.408555156773517 no 2029 0.414393012684286 2869 6832902 SGTC_818 4072-2707 53.5 µM -0.218483170840759 0.407621579514625 no 2030 0.413526334664478 2760 882871 SGTC_1245 0418-0076 17.2 µM -0.218640342226285 0.407555633962987 no 2031 0.413465112230989 2976 6790114 SGTC_1433 4060-0023 7.6 µM -0.220088078070029 0.406948320237326 no 2032 0.412901279752586 2911 3840627 SGTC_1075 aripiprazole 15.2 µM -0.222668592884737 0.405866370252057 no 2033 0.411896723465295 2789 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2543 pimpinellin 60.67 µM -0.223451756461882 0.40553814970183 no 2034 0.411591963305265 2812 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2704 st078022 71.1 µM -0.224399328754309 0.405141114953731 no 2035 0.411223296474302 2958 54697681 SGTC_2458 5808907 16.39 µM -0.224692582869234 0.405018260633254 no 2036 0.411109217548569 2942 2731747 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.225489122062267 0.404684610010804 no 2037 0.410799393413437 2783 2333 A French combination drug. SGTC_1478 0453-0656 35.7 µM -0.225656269725397 0.404614604764921 no 2038 0.410734386243066 2839 5258496 SGTC_1641 st009299 47.1 µM -0.228468023546297 0.403437437648114 no 2039 0.409641206145377 2819 4046054 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.228978731275311 0.403223718582546 no 2040 0.409442723487093 2784 6312947 SGTC_1283 0922-0125 16.4 µM -0.22940237521941 0.403046455574223 no 2041 0.409278095113438 2924 3360884 SGTC_3186 9110464 49.47 µM -0.232174633401938 0.401886968165171 no 2042 0.40820118954602 2938 17018021 SGTC_376 3970-0862 59.1 µM -0.232902701297521 0.40158259895681 no 2043 0.40791848039422 2942 3135186 SGTC_1368 1852-0141 284 µM -0.233090217068346 0.401504217539537 no 2044 0.40784567567749 2922 2838987 SGTC_2215 7188065 200 µM -0.233597371387588 0.401292247368214 no 2045 0.407648784312873 2947 940217 SGTC_2636 apigenin dimethyl ether 100 µM -0.234575088870531 0.400883682690304 no 2046 0.407269273152828 2964 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2345 9052315 157.45 µM -0.234686900932979 0.400836966010152 no 2047 0.407225877682627 2909 6469265 SGTC_1195 1502-0147 41.1 µM -0.234740021251035 0.400814772077771 no 2048 0.407205261511893 2814 817940 SGTC_2717 st081029 62.2815 µM -0.236020092580608 0.400280048896286 no 2049 0.406708539469754 2919 5292846 SGTC_3038 9091290 49.47 µM -0.237451504780361 0.399682327566856 no 2050 0.406153268485091 2964 25236843 SGTC_258 haloperidol 50.781 µM -0.237968835540219 0.399466361142603 no 2051 0.40595263278398 2860 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1944 st076371 56.9 µM -0.238859511863453 0.39909460887964 no 2052 0.405607260864314 2830 24208455 SGTC_2330 7979373 200 µM -0.241579328775773 0.39795997391765 no 2053 0.404553070486624 2841 1863007 SGTC_1357 1503-1303 39.5 µM -0.244160238269521 0.396884084677222 no 2054 0.403553360251117 2848 292895 SGTC_2646 retinol 96.75 µM -0.244658677462741 0.396676393251127 no 2055 0.403360363169434 2913 445354 A vitamin A analog and teratogen. SGTC_1913 st060213 96.1 µM -0.246012118620745 0.396112584551972 no 2056 0.402836425722846 3010 688959 SGTC_1989 st071868 50.2 µM -0.246956024435846 0.395719506227207 no 2057 0.402471128759062 2976 16414057 SGTC_45 0kpi-0036 14.9 µM -0.247064693728468 0.395674258994932 no 2058 0.402429078579138 2978 2795021 SGTC_2755 lomerizine 42.69 µM -0.247096548404224 0.395660995754481 no 2059 0.402416752451264 2887 3949 A calcium channel blocker. SGTC_2150 5556613 200 µM -0.247345117023555 0.39555750409889 no 2060 0.40232057246088 2884 743190 SGTC_1821 st053465 65.6 µM -0.247429652930858 0.39552230921393 no 2061 0.402287863875608 2912 675086 SGTC_362 0310-0100 9.03 µM -0.247876895895392 0.395336122466948 no 2062 0.4021148282713 2980 790235 SGTC_1545 lovastatin 49.4 µM -0.248087060622674 0.395248639373407 no 2063 0.402033523429204 2897 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1235 benzylparaben 21.5 µM -0.248838105169061 0.394936053013516 no 2064 0.401743007158715 2935 7180 SGTC_1379 2144-0755 36.5 µM -0.249213972726824 0.394779641498496 no 2065 0.40159763583553 2997 5392327 SGTC_904 1141-0088 396 µM -0.249446357454338 0.394682946642654 no 2066 0.401507765042527 2887 1378119 SGTC_1673 st016611 27.3 µM -0.250352434180357 0.394305991805762 no 2067 0.401157405262404 3052 5226799 SGTC_1728 st035614 33.7865 µM -0.250857267099525 0.394096009222567 no 2068 0.400962232020795 2949 15945546 SGTC_1642 st009582 77.7 µM -0.252099080674077 0.393579614532567 no 2069 0.400482240268586 2993 6739311 SGTC_1862 st057513 3.81 µM -0.252336263479257 0.393481005893555 no 2070 0.40039058029772 2851 5393163 SGTC_696 1560-0013 611 µM -0.252889082874284 0.393251198020178 no 2071 0.400176962969065 3059 1650269 SGTC_1265 0819-1001 68.8 µM -0.255161099900711 0.392307108376412 no 2072 0.3992993372928 2822 3106768 SGTC_1466 k213-0079 57.5 µM -0.256739296344172 0.391651694014981 no 2073 0.398690016976484 2851 3657981 SGTC_1254 0550-0035 264 µM -0.257662425811702 0.391268466936101 no 2074 0.398333723492295 2991 15121435 SGTC_998 3996-0085 177 µM -0.258173108687944 0.39105650785202 no 2075 0.39813665536901 2928 715391 SGTC_1200 1643-0193 18.4 µM -0.25832541856161 0.390993297853483 no 2076 0.39807788532832 2881 5403974 SGTC_92 0063-0024 660.874 µM -0.259476977826118 0.390515483467087 no 2077 0.397633621459437 2804 3594437 SGTC_670 4204-0025 119 µM -0.261677592625602 0.389602846696317 no 2078 0.396785008611724 2976 719039 SGTC_3019 9081971 49.47 µM -0.262279623932632 0.389353278657663 no 2079 0.396552935024863 3028 16451803 SGTC_320 4092-0846 5.34 µM -0.263317367851939 0.388923196050683 no 2080 0.396152987149221 2962 1359356 SGTC_2064 5220758 200 µM -0.263469597241221 0.388860117533014 no 2081 0.39609432692266 3035 788518 SGTC_63 0099-0242 26.702 µM -0.264956896851347 0.388243987144187 no 2082 0.395521333364948 3030 3898502 YLR359W ADE13 SGTC_349 k015-0014 24 µM -0.265099983532267 0.388184726697525 no 2083 0.395466220011515 2830 2196908 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.266329620137807 0.387675570712646 no 2084 0.394992681524002 3012 61125 An anti-inflammatory. SGTC_487 nimodipine 119 µM -0.266696109645782 0.387523855608189 no 2085 0.39485157475916 2949 4497 L-type voltage-gated calcium channels inhibitor SGTC_2070 5230947 200 µM -0.266887285820573 0.387444721512167 no 2086 0.394777973072326 2979 2835538 SGTC_509 pifithrin 175 µM -0.26695432274338 0.387416973835861 no 2087 0.394752165146094 2949 4817 A p53 inhibitor. SGTC_1768 st044301 37.178 µM -0.267600714350524 0.387149451329496 no 2088 0.394503340519416 2930 3931349 SGTC_38 0929-0051 58.268 µM -0.267829610315127 0.387054730853297 no 2089 0.394415238684711 3009 1379719 SGTC_673 1082-0474 110 µM -0.26839524209638 0.386820693058453 no 2090 0.394197550733424 2900 3098046 SGTC_3315 9136395 68.55 µM -0.269300976482392 0.386446018948054 no 2091 0.393849040402742 3050 16876844 SGTC_1910 st062352 60.4 µM -0.270200592862413 0.386073980434946 no 2092 0.393502968307658 2838 2245730 SGTC_2866 9034245 58.44 µM -0.271063974366819 0.385717025431377 no 2093 0.39317091444834 2960 6462273 SGTC_1819 st053448 58.6 µM -0.271108939985823 0.385698437569419 no 2094 0.393153622936972 2906 2857616 SGTC_2970 9090938 41.86 µM -0.271165948773277 0.385674871686697 no 2095 0.393131700532884 3110 17217104 SGTC_471 1-acyl-paf 4 µM -0.271549428988619 0.385516362362554 no 2096 0.392984244213343 2884 16759367 SGTC_1106 tegaserod maleate 11.7 µM -0.271848276642989 0.3853928486711 no 2097 0.392869341562389 2935 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2276 7947513 42.08 µM -0.272212392006573 0.385242375554225 no 2098 0.392729357026212 2963 2105100 SGTC_3026 9090633 49.47 µM -0.274645728731466 0.384237227363908 no 2099 0.391794215161019 2881 25236842 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.274665031908573 0.384229256824446 no 2100 0.391786799357178 3008 5357218 A potent inhibitor of glutathione S-transferases. SGTC_379 3970-0972 5.9 µM -0.276436320429145 0.383498076917204 no 2101 0.391106481723901 2933 2898042 YBL034C STU1 SGTC_94 0334-0113 514.748 µM -0.27758293408592 0.383024980915542 no 2102 0.390666267059976 2916 6795178 SGTC_774 k060-0086 136 µM -0.277913229028233 0.382888732628642 no 2103 0.390539484247557 3041 5911235 SGTC_581 0958-0271 211 µM -0.2781482769875 0.382791783013813 no 2104 0.390449268816345 2901 4591145 SGTC_345 1362-0200 395 µM -0.280968352452114 0.381629168107686 no 2105 0.389367336763456 2913 1419823 SGTC_1787 fluconazole 80 µM -0.28222921126435 0.381109706275567 no 2106 0.388883880509176 2968 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_710 3448-4187 58 µM -0.283255589131036 0.380687006437378 no 2107 0.388490459211077 2948 3946412 SGTC_717 1532-0246 73.2 µM -0.284316281089325 0.380250324408627 no 2108 0.388084005130305 2988 9561992 SGTC_2017 5132927 60.65 µM -0.285173207017069 0.379897643325576 no 2109 0.387755723083764 2920 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3298 9116858 71.43 µM -0.285318271411792 0.379837949712254 no 2110 0.387700157909354 3062 2506942 SGTC_1196 1588-0294 184 µM -0.286341997826005 0.379416770482807 no 2111 0.387308097242558 2963 6144269 SGTC_1810 st050138 53 µM -0.287130689179573 0.379092386386646 no 2112 0.387006127254508 3024 3444541 SGTC_2138 5575593 77.673 µM -0.287206689589546 0.379061132359902 no 2113 0.386977032227303 2926 762213 SGTC_1798 st045719 60.953 µM -0.287963175067247 0.3787500822038 no 2114 0.386687463625739 2913 3980186 SGTC_2791 5663188 71.43 µM -0.288857238526538 0.378382564264939 no 2115 0.3863453140598 3080 54690634 SGTC_121 0557-0495 61.343 µM -0.28905564467807 0.378301021398257 no 2116 0.386269397886186 2913 3104427 SGTC_773 4358-1457 44.6 µM -0.289194297802433 0.378244039621838 no 2117 0.38621634760595 3090 1186886 SGTC_230 MPP+ 141.667 µM -0.289224109282543 0.378231788450789 no 2118 0.386204941668566 2956 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1709 st033179 39.1045 µM -0.289642707619637 0.37805977638566 no 2119 0.386044795420428 2912 573381 SGTC_1955 wogonin 32.4 µM -0.289659779927107 0.378052761479087 no 2120 0.386038264353949 3138 5281703 A flavanone. SGTC_2989 9073649 71.4286 µM -0.290431316319545 0.377735783898846 no 2121 0.385743144347307 2946 21367202 SGTC_3091 9116372 49.47 µM -0.290821378379454 0.37757556233382 no 2122 0.385593967055196 3074 17169793 SGTC_3302 9125395 16.351 µM -0.29114945951467 0.377440816309927 no 2123 0.385468507160048 2963 17599668 SGTC_10 0279-0212 42.575 µM -0.291733430994679 0.377201010618739 no 2124 0.385245223151557 2933 39851 YBR002C RER2 SGTC_1079 idarubicin 2.36 µM -0.291891671558319 0.377136037876266 no 2125 0.385184725737994 3030 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1971 st069429 63.5 µM -0.29323329356533 0.376585314873136 no 2126 0.384671918710822 3071 1246522 YGL099W LSG1 SGTC_506 n9-isopropylolomoucine 153 µM -0.293655586361643 0.376412019621258 no 2127 0.384510547794407 3073 6610355 SGTC_2767 sibutramine 71.45 µM -0.294051516116915 0.376249565528607 no 2128 0.38435926917233 3129 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2078 5212016 200 µM -0.294380730017836 0.376114502335126 no 2129 0.384233495053124 2907 1899708 SGTC_1285 0929-0069 65.5 µM -0.294393971856085 0.376109070059941 no 2130 0.384228436346251 2951 1206237 SGTC_1094 duloxetine 25.4 µM -0.294428224762867 0.376095018407586 no 2131 0.384215350987534 2900 60834 A selective serotonin reuptake inhibitor. SGTC_282 k297-0036 65.7 µM -0.294785478620318 0.37594847109242 no 2132 0.384078880077613 3069 5061378 SGTC_2670 beta-carotene 100 µM -0.295278953023774 0.375746074853759 no 2133 0.383890396582587 3039 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2315 7733312 200 µM -0.295593702959595 0.375616999478031 no 2134 0.383770191582403 2940 726316 SGTC_2231 micatex 6.853 µM -0.296511909282097 0.375240533071989 no 2135 0.38341958669227 2966 20737 An antifungal of unknown mechanism. SGTC_3173 9105693 49.47 µM -0.297247193864635 0.374939150578332 no 2136 0.383138896842138 3089 17096658 SGTC_2148 5546263 113.568 µM -0.297990000668304 0.374634762360477 no 2137 0.382855397721871 2911 792097 SGTC_1365 1672-3266 55.4 µM -0.298548237119088 0.374406058981264 no 2138 0.382642382880544 3045 6415873 SGTC_2038 4100038 30.985 µM -0.299536158577846 0.374001426674169 no 2139 0.382265493580263 3035 3596803 SGTC_1313 1220-0047 237 µM -0.299779791519728 0.373901660950619 no 2140 0.382172565415792 2989 3528706 SGTC_2658 polymyxin b sulfate 77.05 µM -0.301011626252989 0.373397364020214 no 2141 0.381702814490366 2963 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2922 7999257 32.47 µM -0.304015841858094 0.372168388148766 no 2142 0.380557910995486 2927 2988377 SGTC_90 0870-0863 4.608 µM -0.304145333879097 0.372115444221523 no 2143 0.380508585148191 2904 1738164 SGTC_2094 5332512 191.667 µM -0.304950830811416 0.371786164195654 no 2144 0.380201800487888 3099 755774 SGTC_2323 6148992 148.28 µM -0.305279606737584 0.371651790437517 no 2145 0.380076603267431 2970 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1289 0976-0073 69.1 µM -0.305805124320415 0.371437039025033 no 2146 0.379876513313158 3050 3391136 SGTC_1197 1601-0112 267 µM -0.306405177813347 0.371191877634522 no 2147 0.379648083253788 2940 7350313 SGTC_1421 4029-0249 71.4 µM -0.306423268668833 0.371184487139074 no 2148 0.379641197027561 3098 2894095 SGTC_2569 tetrandrine 100 µM -0.307050955157419 0.370928093424358 no 2149 0.379402293828789 2993 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.30714318366028 0.370890425288535 no 2150 0.379367194697313 2947 4620898 SGTC_1440 4100-1550 40 µM -0.309703765242492 0.36984512301522 no 2151 0.37839311961034 2981 742806 SGTC_3043 9092303 49.47 µM -0.310669246768476 0.36945123503083 no 2152 0.378026039332449 2991 25236084 SGTC_2537 larixol 68.93 µM -0.311586595255267 0.369077110806231 no 2153 0.377677361432666 2965 6708759 SGTC_1776 st049249 45.9 µM -0.31434443711337 0.367953122162021 no 2154 0.376629725731413 3008 1822314 SGTC_297 0986-0032 24 µM -0.314918799662488 0.367719176230868 no 2155 0.376411653631344 2933 2847425 SGTC_2146 5545642 200 µM -0.316851795073628 0.366932200979559 no 2156 0.375678030338878 3008 825326 SGTC_1472 k841-0093 193 µM -0.316914392474573 0.366906725192059 no 2157 0.375654280451753 3090 X1472 SGTC_2313 7726885 200 µM -0.318087948830525 0.366429221765773 no 2158 0.375209112354946 3051 726423 SGTC_2269 7935389 174.42 µM -0.318695818421566 0.366181969470445 no 2159 0.37497859293098 2949 97605 SGTC_1764 st044502 93.5 µM -0.319217517972195 0.365969811320413 no 2160 0.374780786955748 3102 8407 SGTC_1512 0259-0544 12.2 µM -0.319558327683053 0.36583123727758 no 2161 0.37465158439274 2978 18476 SGTC_2340 7987427 183.45 µM -0.319568180960201 0.365827231171804 no 2162 0.374647849178283 3098 2239331 SGTC_3144 9087057 49.47 µM -0.320701045646491 0.365366733250172 no 2163 0.374218477400804 3111 17249618 SGTC_1256 0570-0116 285 µM -0.321934060695663 0.364865745747128 no 2164 0.3737513244913 3001 410638 SGTC_2628 lathosterol 100 µM -0.322197666219837 0.364758669834125 no 2165 0.373651476193409 3148 6710616 SGTC_2512 diallyl trisulfide 49.23 µM -0.323572895992424 0.364200226130418 no 2166 0.373130705380091 3025 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_841 0251-0215 91.2 µM -0.324072260195635 0.363997519062813 no 2167 0.372941663869796 3025 3888614 SGTC_3254 9136651 49.47 µM -0.324299918556581 0.363905118256862 no 2168 0.372855490668207 3017 16454030 SGTC_2232 chlorophetanol 41.5365 µM -0.324584192904635 0.363789749554886 no 2169 0.372747896125709 3064 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2911 7942208 15.64 µM -0.324639227632171 0.363767415919594 no 2170 0.372727067266622 3059 1243384 SGTC_9 0092-0002 10.449 µM -0.324958826422008 0.363637728728952 no 2171 0.372606116849423 3031 759368 SGTC_1464 k208-0027 110 µM -0.325415229157694 0.363452556153093 no 2172 0.372433415505055 3175 X1464 SGTC_1655 st012546 55.1 µM -0.327508138170179 0.362603826316989 no 2173 0.371641794350242 3088 720985 YLR208W SEC13 SGTC_1502 4534-4282 27.7 µM -0.327845900370681 0.362466917951608 no 2174 0.37151409004871 3004 3278949 SGTC_2888 9058547 12.99 µM -0.327910953733946 0.362440551272333 no 2175 0.371489495686418 2978 16476514 SGTC_3291 9121177 71.43 µM -0.328428999585053 0.362230606195641 no 2176 0.371293659711927 3023 17015612 SGTC_1162 k048-0130 20.1 µM -0.329155330622407 0.361936320519528 no 2177 0.371019142163256 2986 6797406 SGTC_2109 5483026 200 µM -0.329651753500641 0.361735233080081 no 2178 0.370831556380006 3017 759335 SGTC_2187 6125751 200 µM -0.330409411461079 0.361428400002984 no 2179 0.370545315585027 3012 874498 SGTC_3092 9117248 49.47 µM -0.331330066767244 0.361055676888576 no 2180 0.370197591346017 3035 17141857 SGTC_706 4262-0057 46.9 µM -0.332216697011401 0.360696853322112 no 2181 0.369862818348286 2999 883298 SGTC_1987 st072290 61.9 µM -0.333658953873497 0.360113427013318 no 2182 0.369318463122155 3045 54697379 SGTC_3325 9138760 55.175 µM -0.334180127962605 0.359902680056636 no 2183 0.369121819226458 3014 43844959 SGTC_1704 st028805 70.8 µM -0.336436943651272 0.358990584570386 no 2184 0.368270697223317 3059 2876101 SGTC_721 1187-1332 279 µM -0.337562283898188 0.358536076406026 no 2185 0.367846534246444 2917 25730 SGTC_2729 fluphenazine 10.66 µM -0.337601380794484 0.358520289348667 no 2186 0.367831800746553 2986 3372 An atypical antipsychotic. SGTC_1321 1326-2144 215 µM -0.339170497893341 0.357886890510606 no 2187 0.36724064634577 3107 3513030 SGTC_199 4063-0024 41.6 µM -0.339624971878543 0.357703507884981 no 2188 0.367069484988447 3114 306215 SGTC_2943 9068529 45.32 µM -0.33990318822373 0.35759126234066 no 2189 0.366964717795338 2992 3270634 SGTC_2591 skatole 100 µM -0.339931725058705 0.357579749937039 no 2190 0.366953972314961 3120 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2793 7325131 81.82 µM -0.340687148685251 0.357275042136077 no 2191 0.36666955719071 3046 4176441 SGTC_3223 9129970 49.47 µM -0.341251709746704 0.357047380087962 no 2192 0.366457049128797 2958 17248386 SGTC_133 0724-0033 378.92 µM -0.343088253559532 0.356307137107053 no 2193 0.365766033862748 2929 280309 SGTC_2931 9014674 55.67 µM -0.343145079471138 0.356284241297476 no 2194 0.365744659560835 2978 2996810 SGTC_991 3996-0057 64.7 µM -0.345061470743316 0.355512409157564 no 2195 0.365024079195242 3080 715343 SGTC_2208 7283366 200 µM -0.34509725595541 0.355498002181918 no 2196 0.365010628156656 3090 898663 SGTC_2726 cimetidine 79.27 µM -0.346421635753142 0.354964957828105 no 2197 0.364512933795047 2998 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2483 5729050 27.16 µM -0.347983609803324 0.354336649834893 no 2198 0.363926246322196 3191 2865180 SGTC_748 act1.228 77.9 µM -0.34896193469777 0.353943317884555 no 2199 0.363558943508589 3011 4421505 YNR035C ARC35 SGTC_1479 0549-0158 134 µM -0.349661547535028 0.353662136628712 no 2200 0.363296357364791 3063 5440202 SGTC_810 3825-7150 143 µM -0.354122845190038 0.351870980543757 no 2201 0.361623411005325 3199 22330411 YGL099W LSG1 SGTC_2382 9035899 200 µM -0.354447420161985 0.351740795310193 no 2202 0.361501801025978 3047 6462679 SGTC_1355 1499-0035 1.68 µM -0.35502618527049 0.35150869895433 no 2203 0.361284987194587 3026 1548538 SGTC_158 k038-0087 26.446 µM -0.355148076021171 0.351459825384424 no 2204 0.361239330822253 2982 X158 SGTC_1220 1838-0075 193 µM -0.356610461769493 0.350873655810396 no 2205 0.360691722211836 3056 5529645 SGTC_723 4182-0001 115 µM -0.360527081470746 0.34930550374699 no 2206 0.35922650413617 3064 744821 YLR208W SEC13 SGTC_2774 tamoxifen 10.92 µM -0.361447093722789 0.348937517130383 no 2207 0.358882624196176 3061 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1530 rhein 70.4 µM -0.363759819976301 0.348013100516217 no 2208 0.358018684522931 3033 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1993 st073995 70.8 µM -0.36669479414866 0.346841265871691 no 2209 0.356923345071862 3052 3098394 SGTC_2912 7964298 10.93 µM -0.367035625445321 0.346705278247062 no 2210 0.356796222208711 3128 2975850 SGTC_3305 9127027 53.8275 µM -0.367391324374203 0.346563379673679 no 2211 0.356663570990816 3060 41905295 SGTC_1915 st067105 30.6 µM -0.367827500385129 0.346389405853059 no 2212 0.356500931022164 3074 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2905 7799065 20.05 µM -0.368346600001627 0.34618239922796 no 2213 0.356307404760418 3225 1296806 SGTC_885 0865-0106 16.8 µM -0.36870371431736 0.346040015800464 no 2214 0.356174289947729 3042 2793380 SGTC_3351 9150312 21.596 µM -0.369401681824901 0.345761795196944 no 2215 0.355914172291357 3132 4904905 SGTC_921 1561-0023 372 µM -0.369525166077868 0.345712581136316 no 2216 0.355868159312902 3021 24050882 SGTC_113 0099-0221 2.5 µM -0.369798915246116 0.345603489006993 no 2217 0.355766161772967 3241 89219 SGTC_1850 st056238 17 µM -0.371334166029435 0.344991912066618 no 2218 0.355194326694765 3066 5393177 SGTC_698 k064-0052 127 µM -0.371433650277434 0.344952295827405 no 2219 0.355157283013802 3139 5088751 SGTC_866 0495-0101 262 µM -0.373014055024302 0.344323181266842 no 2220 0.354568991650482 3041 635694 SGTC_1902 st060212 70.5 µM -0.373250962860589 0.34422891200034 no 2221 0.354480834703071 3146 688944 SGTC_2137 5261020 140 µM -0.374283573945943 0.343818133282252 no 2222 0.354096675771648 3046 763655 SGTC_2121 5257820 149.641 µM -0.37589144121767 0.343178881346477 no 2223 0.353498801813783 3217 791256 SGTC_151 3013-0144 2.285 µM -0.377954303983472 0.34235939038583 no 2224 0.352732270248959 3246 906558 YHR107C CDC12 SGTC_1888 azatryptophan 97.5 µM -0.379039919650461 0.341928417309584 no 2225 0.352329110076622 3167 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_330 1488-0319 80.1 µM -0.379171482075105 0.341876202984215 no 2226 0.352280263595035 3148 6846614 SGTC_2655 perillic acid 100 µM -0.379981634961624 0.341554737240366 no 2227 0.351979523854859 3082 5702197 An apoptosis inducer. SGTC_2050 5263056 171 µM -0.38052978581362 0.341337298112612 no 2228 0.351776095316598 3216 763468 YGL055W OLE1 SGTC_870 0573-2213 57.6 µM -0.381226052477407 0.341061180704472 no 2229 0.351517759544902 3111 3916321 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.381896025935882 0.340795570685115 no 2230 0.351269244065519 3052 3256 An antibiotic and ribosome inhibitor. SGTC_929 2805-0021 398 µM -0.382473238822895 0.340566798730665 no 2231 0.351055187552058 3152 3098024 SGTC_724 3910-0327 137 µM -0.383564655784951 0.340134387998816 no 2232 0.350650570219067 3156 2885483 SGTC_2802 7925815 54.55 µM -0.383719495756218 0.340073058643063 no 2233 0.350593180625799 3054 1262923 SGTC_2449 5812982 45.77 µM -0.383806922675326 0.340038432265969 no 2234 0.350560778384369 3165 776185 SGTC_489 paxilline 115 µM -0.386657189131867 0.338910293902065 no 2235 0.349505006869356 3153 105008 A toxic potassium channel blocker. SGTC_3169 9102970 49.47 µM -0.387045505090206 0.338756709535298 no 2236 0.349361260012666 3159 17027839 SGTC_1438 4092-1045 4 µM -0.387050584293506 0.338754700817238 no 2237 0.349359379935558 3084 1351342 SGTC_2544 sphondin 68.51 µM -0.388008414606853 0.338375981108779 no 2238 0.349004903272161 3266 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_933 2914-0560 114 µM -0.388731076056406 0.338090353742287 no 2239 0.348737545756315 3251 463887 SGTC_2151 5563267 85.4165 µM -0.389403475912669 0.33782467562468 no 2240 0.348488850577282 3122 5310824 SGTC_966 1300-0360 30.2 µM -0.391816033128577 0.336872093533484 no 2241 0.347597073827727 3081 70588 SGTC_3049 9092223 49.47 µM -0.391906479211374 0.33683640179593 no 2242 0.347563657730144 3180 8623917 SGTC_2052 5265182 7.135 µM -0.391985249503436 0.3368053187436 no 2243 0.347534556320692 3229 1239884 SGTC_428 3448-4153 16.5 µM -0.393692703248951 0.336131825356754 no 2244 0.346903964588849 3009 3834874 SGTC_2988 9073640 71.4286 µM -0.394130772470724 0.335959116615038 no 2245 0.346742246412211 3294 9102229 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.394374754907494 0.3358629415791 no 2246 0.346652189656903 3193 140250 A respiratory chain inhibitor. SGTC_610 4215-0184 155 µM -0.394801100181885 0.335694907038256 no 2247 0.346494841459831 3157 5605015 SGTC_245 methotrexate 289.6 µM -0.39494126487306 0.335639671404743 no 2248 0.346443117664293 3167 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_508 roscovitine 141 µM -0.395033318200882 0.335603397268601 no 2249 0.346409149557611 3105 160355 A CDKinase inhibitor. SGTC_2508 celastrol 40.54 µM -0.39785907808588 0.33449063729743 no 2250 0.345367033093737 3145 122724 Celastrol is a natural product and antioxidant. SGTC_667 1498-1044 59 µM -0.398126066922761 0.33438557433725 no 2251 0.345268630292795 3138 6739982 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.398210186653366 0.334352475011162 no 2252 0.345237628851827 3105 4174840 SGTC_533 1222-0222 6.71 µM -0.399242691916458 0.333946311113996 no 2253 0.344857194563185 3274 3982874 SGTC_2776 terbinafine 19.92 µM -0.399462841196231 0.333859734568176 no 2254 0.344776099181815 3173 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2419 paclitaxel 166.5 µM -0.400053461359766 0.333627509262764 no 2255 0.344558570377734 3094 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1766 st045414 44.774 µM -0.400101137171598 0.333608766440289 no 2256 0.344541013342742 3121 253960 SGTC_1616 st002734 56.1 µM -0.400133367517869 0.333596095938854 no 2257 0.344529144425357 3092 4026101 SGTC_783 0848-0141 92.7 µM -0.401687410120462 0.332985390955689 no 2258 0.343957045594451 3129 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2598 perillyl alcohol 100 µM -0.402282339878402 0.332751713577128 no 2259 0.343738125044308 3248 10819 An apoptosis inducer. SGTC_661 1304-0007 33.6 µM -0.403106170179614 0.332428235573228 no 2260 0.343435060841004 3147 3117130 SGTC_482 fipronil 114 µM -0.40478797936799 0.331768258617331 no 2261 0.342816682705948 3179 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1853 st056710 91.2 µM -0.40536016574464 0.331543839617759 no 2262 0.342606393506224 3264 269167 SGTC_825 1988-2224 89.6 µM -0.405902671379137 0.331331117627685 no 2263 0.342407057573779 3110 1180859 SGTC_1594 piperine 70.1 µM -0.40689801872291 0.330940973312794 no 2264 0.342041445604576 3111 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3295 9122362 53.5725 µM -0.407002762173114 0.33089992789678 no 2265 0.342002979741091 3210 4730473 SGTC_2782 7736369 71.43 µM -0.407485560077247 0.3307107620086 no 2266 0.341825698801523 3137 2950836 YOL077C BRX1 SGTC_1101 ebselen 5.29 µM -0.409151502346086 0.33005835844679 no 2267 0.341214241254408 3272 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1914 st062367 72.6 µM -0.409778586338853 0.329812918292399 no 2268 0.34098418792862 3102 978205 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.41017539309147 0.329657646297343 no 2269 0.340838645115985 3304 94937 An inhibitor of serotonin biosynthesis. SGTC_1633 st005664 67.9 µM -0.410218081923623 0.329640943743123 no 2270 0.340822988898383 3079 2063822 SGTC_1832 st054113 55 µM -0.410391784844656 0.329572983747368 no 2271 0.340759285820093 3243 1251267 SGTC_3184 9108758 49.47 µM -0.410622026844586 0.32948291192502 no 2272 0.340674854836833 3110 902885 SGTC_2132 5317594 122.667 µM -0.411189507052501 0.329260953074908 no 2273 0.340466790872385 3084 794577 SGTC_2617 dihydrotanshinone i 20.83 µM -0.411637931303024 0.329085603196431 no 2274 0.340302412551184 3120 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2849 9019321 12.99 µM -0.412843743789526 0.328614274074513 no 2275 0.339860549920349 3217 16489627 SGTC_2567 aureobasidin a 60 nM -0.413018162694424 0.328546119592962 no 2276 0.339796653369352 3326 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2749 bexarotene 57.39 µM -0.413511291201448 0.32835345966143 no 2277 0.339616025779954 3187 82146 An retinoic acid receptor inhibitor. SGTC_13 0199-0087 65 µM -0.414922453931897 0.32780238607084 no 2278 0.339099335892149 3174 4589825 SGTC_1135 dihydrocapsaicin 536.708 nM -0.415700889637988 0.327498559212763 no 2279 0.33881444509057 3082 107982 A Capsaicinoid. SGTC_72 0744-0168 198.391 µM -0.416954431950999 0.327009536270116 no 2280 0.338355869233116 3048 677577 SGTC_1692 fluoroquinolonic acid 71 µM -0.417978240158294 0.326610355760608 no 2281 0.337981513370121 3250 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1401 3807-4679 7.6 µM -0.419085308345387 0.326178935660431 no 2282 0.337576893704459 3199 3291456 SGTC_3261 9137475 49.47 µM -0.419488411782336 0.326021905556668 no 2283 0.337429610996668 3164 17027690 SGTC_284 0988-0104 32.6 µM -0.422137961109508 0.324990534828892 no 2284 0.336462160558933 3206 4666532 SGTC_1374 2889-5571 141 µM -0.423527614215126 0.324450129774041 no 2285 0.335955177774008 3186 2853281 SGTC_2482 5981709 142.65 µM -0.423775417750479 0.32435380329815 no 2286 0.33586480370335 3178 877755 SGTC_168 3970-0862 530.542 µM -0.424108087031491 0.324224506192142 no 2287 0.335743493976069 3232 3135186 SGTC_559 1550-0661 158 µM -0.424413807445704 0.324105701871824 no 2288 0.335632026395301 3225 5830875 SGTC_2359 9039622 200 µM -0.424803476397625 0.32395430073759 no 2289 0.335489971616468 3116 6463596 SGTC_2339 9000433 200 µM -0.425521114404796 0.323675547420564 no 2290 0.335228416447062 3176 2988954 SGTC_2596 sinensetin 100 µM -0.425828948479407 0.323556005222306 no 2291 0.335116245640699 3157 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2176 5809774 33.9695 µM -0.426162400025222 0.323426535451449 no 2292 0.334994756744335 3243 2870539 SGTC_619 1652-1634 108 µM -0.427156723606141 0.323040594786044 no 2293 0.334632589925909 3166 5400454 SGTC_983 1491-0821 12.2 µM -0.428266280710885 0.322610151749308 no 2294 0.334228632669947 3256 46495113 SGTC_772 k072-0172 35.3 µM -0.429353070618115 0.322188771389546 no 2295 0.333833150324168 3162 5861980 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.432660940721473 0.320907620575555 no 2296 0.332630554887489 3148 688803 SGTC_1026 k007-1105 30.6 µM -0.432721729873829 0.320884096584948 no 2297 0.332608470698355 3205 7066794 SGTC_3311 9131146 2.8755 µM -0.433862738317486 0.320442686309627 no 2298 0.332194059757311 3188 4900406 YPR165W RHO1 SGTC_1189 1431-2119 7.28 µM -0.435227636914324 0.319914995446113 no 2299 0.331698602018265 3258 3107275 SGTC_862 0452-0056 10.2 µM -0.43617881922542 0.319547468943616 no 2300 0.331353497082102 3243 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1726 st035556 14.5795 µM -0.437752843843065 0.318939672231182 no 2301 0.330782729047295 3338 5919439 SGTC_1184 1269-1718 139 µM -0.437797887199292 0.318922286261713 no 2302 0.330766401342772 3304 5403821 SGTC_1648 st011736 69.8 µM -0.439578362804741 0.318235372426767 no 2303 0.33012125735658 3314 2855514 SGTC_1002 4049-0206 172 µM -0.44073809392737 0.317788279771804 no 2304 0.329701307525217 3164 4662749 SGTC_3356 9151811 4.48 µM -0.44286178161031 0.316970256947096 no 2305 0.32893285633134 3150 1859254 YPR165W RHO1 SGTC_2762 leflunomide 42.06 µM -0.44316645812329 0.316852971885544 no 2306 0.328822669068363 3199 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3239 9133757 49.47 µM -0.443932386240024 0.316558209569947 no 2307 0.32854573437201 3229 17036923 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.445164824620851 0.316084158424218 no 2308 0.328100322417629 3266 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_64 000l-0018 272.079 µM -0.448043173682321 0.314978194222492 no 2309 0.327061019193675 3181 6811119 SGTC_849 0386-0493 241 µM -0.449133742976884 0.31455959092599 no 2310 0.326667590141487 3176 726119 SGTC_2051 5263410 176 µM -0.449476071837603 0.314428240782056 no 2311 0.326544132777069 3322 227584 SGTC_2838 9002687 71.43 µM -0.450909058167612 0.313878665062112 no 2312 0.326027547379345 3143 6457060 SGTC_334 1502-1024 68.5 µM -0.451112180398401 0.313800797440344 no 2313 0.325954349672295 3291 3296216 SGTC_2786 7743617 45.45 µM -0.451316738866847 0.313722387612653 no 2314 0.325880641176715 3183 583674 SGTC_1494 4358-1428 177 µM -0.452012721696876 0.313455671687527 no 2315 0.325629908853935 3331 1564571 SGTC_797 k781-0471 270 µM -0.452377284054052 0.3133160022831 no 2316 0.325498604372127 3195 23738129 SGTC_1749 st037932 54.2 µM -0.452414419523002 0.313301776620111 no 2317 0.325485230499326 3302 594497 SGTC_1948 st076329 66.6 µM -0.452672110373712 0.313203069397485 no 2318 0.325392432565508 3229 24208413 SGTC_677 0929-0063 136 µM -0.452750277993732 0.313173130317242 no 2319 0.325364285495915 3256 1539583 SGTC_1378 2093-0007 380 nM -0.45354382094422 0.312869264154614 no 2320 0.325078598158176 3287 3618014 SGTC_2423 st077119 87.2 µM -0.456561557735207 0.311714864208656 no 2321 0.323993107792998 3259 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_60 0986-0278 202 µM -0.457016329968732 0.311541056345363 no 2322 0.323829654039301 3164 3110598 SGTC_2858 9025781 8.96 µM -0.457416487826283 0.311388156089159 no 2323 0.323685857820173 3282 4894980 YPL153C RAD53 SGTC_2154 5570129 200 µM -0.457565171247905 0.31133135246373 no 2324 0.323632435326078 3299 673366 SGTC_1342 1486-1464 234 µM -0.458089802722787 0.311130955993886 no 2325 0.323443962371922 3213 3253938 SGTC_1335 1486-0900 202 µM -0.458943098556323 0.310805137307173 no 2326 0.323137514067225 3234 X1335 SGTC_1461 k072-0203 53.8 µM -0.459037473595178 0.310769110665222 no 2327 0.323103628064016 3231 5418714 SGTC_1861 st057647 17.4 µM -0.459919221210117 0.31043260082203 no 2328 0.322787101512355 3364 688668 SGTC_3094 9117742 49.47 µM -0.461236383077647 0.309930215110292 no 2329 0.322314510638355 3193 17149698 SGTC_1775 st081588 35.1725 µM -0.462086232201015 0.309606257827524 no 2330 0.322009741461334 3317 1426443 YGL099W LSG1 SGTC_659 k018-0002 107 µM -0.462614412467715 0.309404993229682 no 2331 0.321820388046818 3334 6797879 YHR007C ERG11 SGTC_3268 9137683 49.47 µM -0.464109444426528 0.308835617067791 no 2332 0.321284667788867 3199 1953228 SGTC_1325 1431-0015 227 µM -0.464338639481641 0.308748369722511 no 2333 0.321202572314249 3202 1103340 SGTC_306 1672-3436 11.6 µM -0.464854440837031 0.308552059860557 no 2334 0.321017849166283 3316 6797378 SGTC_1066 ketoconazole 628 nM -0.466130001566206 0.308066826705263 no 2335 0.32056122481785 3342 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1296 1068-0102 11.9 µM -0.46789937736169 0.307394297722793 no 2336 0.319928274387393 3278 767053 SGTC_2752 diclazuril 33.15 µM -0.46854880208213 0.307147617542535 no 2337 0.319696090081205 3302 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1743 st037606 46.3785 µM -0.468660890637268 0.307105050186799 no 2338 0.319656022985354 3219 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1884 5633444 25 µM -0.468804967300596 0.3070503386723 no 2339 0.319604524534387 3341 5724239 SGTC_1178 0988-0033 191 µM -0.469964114091134 0.306610321933888 no 2340 0.319190328246128 3330 5392207 SGTC_2996 9066192 71.4286 µM -0.470870916954321 0.306266290137776 no 2341 0.318866458895148 3252 6472854 SGTC_486 niguldipine 82 µM -0.471133664123577 0.30616663842158 no 2342 0.318772643204297 3240 1236 A calcium channel blocker. SGTC_2353 9059630 146.67 µM -0.471749070717649 0.305933290243711 no 2343 0.318552953492255 3309 4779114 SGTC_961 1252-1571 372 µM -0.473149899458202 0.305402421604673 no 2344 0.318053119292318 3388 6813498 SGTC_2736 butenafine 14.65 µM -0.473529199965166 0.305258749331637 no 2345 0.317917836806097 3226 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2844 9010103 25.97 µM -0.474370810247877 0.304940069501885 no 2346 0.317617752276527 3360 2480525 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.47460887128795 0.304849953353004 no 2347 0.317532890966925 3261 688761 SGTC_3138 9097216 49.47 µM -0.475114013712454 0.304658774840837 no 2348 0.317352855263783 3315 25237486 SGTC_3180 9109287 49.47 µM -0.475725237330957 0.304427519671974 no 2349 0.317135069373712 3327 18891271 SGTC_3119 9125183 49.47 µM -0.475758155430017 0.304415067396015 no 2350 0.317123342078887 3224 22695334 SGTC_2607 solasodine 47.35 µM -0.476404241306931 0.304170711597375 no 2351 0.316893206817058 3236 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2832 7992762 51.95 µM -0.480463101465746 0.302637615609821 no 2352 0.315449067185334 3130 2985177 SGTC_2880 9042983 58.44 µM -0.480795401102643 0.302512254231037 no 2353 0.315330959557703 3346 6464714 SGTC_1010 4112-3296 15.2 µM -0.480951917389051 0.302453215896238 no 2354 0.315275336278796 3389 704384 SGTC_1021 4476-0760 85.3 µM -0.482423859815132 0.301898248484978 no 2355 0.314752437465221 3241 746768 SGTC_690 glyoxal 20.3 µM -0.484248664975751 0.301210876979958 no 2356 0.314104701671026 3305 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_780 0109-0199 192 µM -0.484513731503427 0.301111089821204 no 2357 0.314010660776646 3392 610414 SGTC_1644 st010134 20.9 µM -0.484543029139856 0.301100061323695 no 2358 0.314000267236889 3353 3818134 SGTC_3216 9129716 49.47 µM -0.484894704074334 0.300967694678288 no 2359 0.313875519631351 3239 8056934 SGTC_2677 mitomycin C 100 µM -0.485020939547993 0.300920187409762 no 2360 0.313830746042848 3306 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1866 st057638 64 µM -0.486338610458237 0.300424499128946 no 2361 0.31336355419391 3263 688802 SGTC_2805 7950783 58.44 µM -0.486796595019851 0.300252298547186 no 2362 0.313201241786434 3329 1178958 YDL195W SEC31 SGTC_327 1273-0057 3.96 µM -0.486958112839624 0.300191579060456 no 2363 0.31314400755547 3284 3108138 SGTC_2504 purpurogallin 52.29 µM -0.487087398264838 0.300142980717363 no 2364 0.313098198195208 3226 5281571 An antioxidant. SGTC_3313 9133968 57.047 µM -0.487563479132039 0.299964052779446 no 2365 0.312929534603939 3335 1494643 SGTC_3011 9081274 71.4286 µM -0.488138968601754 0.299747828056269 no 2366 0.312725705283662 3258 6625322 SGTC_697 0508-1955 564 µM -0.489724725869716 0.299152387879577 no 2367 0.312164351377584 3401 6243113 SGTC_207 4185-0010 4.486 µM -0.490277287840164 0.298945031126774 no 2368 0.311968848215316 3386 3761753 SGTC_2062 5245942 200 µM -0.496400467832891 0.296651604280392 no 2369 0.309805947533975 3385 1376160 SGTC_832 4083-0019 164 µM -0.49675359490666 0.29651958722387 no 2370 0.309681411505007 3381 1990758 SGTC_2343 7990716 14.84 µM -0.49790847364779 0.296088022274072 no 2371 0.309274277257483 3259 6456862 SGTC_556 4058-0063 51.5 µM -0.498813355137143 0.295750079975026 no 2372 0.308955439101894 3328 6615692 SGTC_410 α-linolenic acid 100 µM -0.498929911101172 0.295706563194616 no 2373 0.308914380656511 3393 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1103 duloxetine 36.1 µM -0.499870919427776 0.2953553406261 no 2374 0.308582984986241 3397 60835 A selective serotonin reuptake inhibitor. SGTC_1164 k060-0068 93.7 µM -0.500636387991938 0.295069778286906 no 2375 0.308313524236701 3344 5963676 SGTC_1077 5-fluorocytosine 377 nM -0.50144022864055 0.294770037986476 no 2376 0.308030666859047 3346 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2652 actinonin 100 µM -0.503238562358855 0.294099974794135 no 2377 0.307398277843947 3279 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2120 5538279 151.968 µM -0.503774163230101 0.293900544842202 no 2378 0.307210042808663 3348 2058197 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.503851444003698 0.293871774659196 no 2379 0.307182886944991 3374 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2370 9071495 200 µM -0.50457769672737 0.29360146805348 no 2380 0.306927739053825 3336 21791103 SGTC_144 4161-2749 112.381 µM -0.504685325142982 0.29356141924315 no 2381 0.306889934873618 3297 797501 YMR168C CEP3 SGTC_1547 harmine 94.2 µM -0.5048145603599 0.293513333829016 no 2382 0.306844544077995 3368 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2942 9052777 62.25 µM -0.50845794870044 0.292159217490311 no 2383 0.305566111192155 3361 6469503 SGTC_93 0109-0045 59.227 µM -0.509209848360464 0.291880125723328 no 2384 0.305302570347165 3411 88733 SGTC_3174 9107204 49.47 µM -0.510200908678207 0.291512451607971 no 2385 0.304955357825073 3411 3938802 SGTC_1546 5-methoxyflavanone 78.7 µM -0.511883722729895 0.290888638586556 no 2386 0.304366195372018 3377 147795 SGTC_1046 2001-0062 216 µM -0.512937011468928 0.29049850604428 no 2387 0.303997691241266 3325 739778 SGTC_2061 5245884 80.95 µM -0.51361359516411 0.290248032288851 no 2388 0.303761086298499 3301 573863 SGTC_3034 9090421 49.47 µM -0.513652590408675 0.290233599190708 no 2389 0.303747451957354 3346 17173761 SGTC_2189 6047310 154.431 µM -0.5145666809474 0.289895368175548 no 2390 0.303427926577551 3320 711535 SGTC_150 3970-0969 77.2 µM -0.514572789109144 0.289893108660562 no 2391 0.303425791941149 3390 6615640 SGTC_3324 9138759 60.749 µM -0.514630363008605 0.289871811482282 no 2392 0.30340567175884 3404 45595710 SGTC_3148 9097893 49.47 µM -0.514956836390904 0.289751059497656 no 2393 0.303291591336428 3252 17174100 SGTC_363 0455-0021 3.06 µM -0.51545343564339 0.289567428705957 no 2394 0.303118100174019 3364 4597466 SGTC_546 peri-Naphthalide 147 µM -0.516333102915476 0.289242282509489 no 2395 0.302810889960897 3304 223824 A penicillin ester. SGTC_589 1227-0070 34.1 µM -0.517879608131102 0.288671073393904 no 2396 0.302271135212377 3419 2841384 SGTC_1732 st034308 51.822 µM -0.521485822515434 0.287341168727639 no 2397 0.301014189696502 3280 830119 SGTC_1167 k781-0610 148 µM -0.521612548850223 0.287294487185575 no 2398 0.300970062133128 3329 4525169 SGTC_1615 st002656 86.5 µM -0.521638454193576 0.287284945006427 no 2399 0.300961041954482 3417 1584458 SGTC_2003 4023581 200 µM -0.522110623368689 0.28711104876032 no 2400 0.300796655138256 3408 16641307 SGTC_909 3448-9333 149 µM -0.522310858648761 0.287037318711537 no 2401 0.300726954985313 3316 3344074 SGTC_1188 1403-0014 4.57 µM -0.522865482729522 0.286833143486401 no 2402 0.30053393324789 3334 9614867 SGTC_1682 st012968 530 nM -0.522951655464894 0.286801426669092 no 2403 0.300503948207207 3272 24207270 SGTC_2850 9015429 58.44 µM -0.52381697927612 0.286483026973323 no 2404 0.300202921298808 3343 6457570 SGTC_2192 5915882 198.485 µM -0.527063093424498 0.285290102161483 no 2405 0.299074887442151 3354 2876149 SGTC_674 0498-0004 451 µM -0.527922585669446 0.284974641321425 no 2406 0.298776533979851 3359 4231473 SGTC_625 k213-0058 121 µM -0.528765686791518 0.284665358259843 no 2407 0.298484001826061 3409 3655420 SGTC_3079 9117512 49.47 µM -0.529388762063708 0.284436892462237 no 2408 0.29826789617053 3409 7185044 SGTC_3213 9129884 49.47 µM -0.530677389844392 0.283964663686601 no 2409 0.297821178367766 3366 17190742 SGTC_945 3381-0768 11.3 µM -0.530892240178235 0.283885966430724 no 2410 0.297746727689492 3435 1126236 YIL048W NEO1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.531088055823422 0.283814250460795 no 2411 0.29767888037348 3345 5711223 A potent inhibitor of glutathione S-transferases. SGTC_586 0957-0265 8.15 µM -0.531711446033752 0.283585996381931 no 2412 0.297462931588916 3371 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_119 0121-0043 24.815 µM -0.532436620446455 0.283320584773235 no 2413 0.297211813762276 3463 1092378 SGTC_2489 cantharidin 73.42 µM -0.533189914233053 0.283045007759315 no 2414 0.29695106123987 3424 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1857 st056007 79.3 µM -0.533518752347545 0.282924749462049 no 2415 0.296837266805019 3428 619834 SGTC_1757 st041620 31.8375 µM -0.533805508938141 0.282819900688959 no 2416 0.296738050975927 3388 5289815 SGTC_3168 9103419 49.47 µM -0.534687813949446 0.282497414583709 no 2417 0.296432874716327 3379 16649256 SGTC_2728 chlorpromazine 9.18 µM -0.535760223763706 0.282105682617359 no 2418 0.29606213782789 3385 2726 A thorazine and dopamine antagonist. SGTC_2473 5854593 8.94 µM -0.536482701065161 0.28184192222113 no 2419 0.295812494217364 3317 2872951 SGTC_1891 st059073 26.2 µM -0.539302248960423 0.280813706383876 no 2420 0.294839158647593 3461 688754 SGTC_1952 st077036 64.1 µM -0.541295499895976 0.280087915586876 no 2421 0.294151960872195 3436 2937007 SGTC_273 hydroxyurea 18.1 mM -0.541568246640609 0.279988672670354 no 2422 0.29405798567224 3415 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1623 st003709 20.3 µM -0.541683716650723 0.279946662345274 no 2423 0.294018204531153 3385 16192618 SGTC_1341 1486-1360 280 µM -0.541864879610786 0.2798807577563 no 2424 0.293955796203102 3326 3976547 SGTC_2317 5986382 200 µM -0.544701944609531 0.278849655391773 no 2425 0.292979263594501 3449 877883 SGTC_2427 5545055 42.75 µM -0.54484956000953 0.278796056711265 no 2426 0.292928494824653 3388 5372858 SGTC_2929 9013348 24.6 µM -0.545094056665326 0.278707291787923 no 2427 0.292844415057249 3386 2995952 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.545461555853855 0.27857389647589 no 2428 0.292718057122653 3440 279621 SGTC_651 3253-0966 34.4 µM -0.548340953501454 0.277529806791039 no 2429 0.291728905988964 3375 781462 SGTC_16 erodoxin 22.806 µM -0.548600491057032 0.277435790699024 no 2430 0.291639824388109 3472 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_120 rhodamine 6G 52.259 µM -0.548768913374301 0.277374788945886 no 2431 0.291582023240337 3349 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_981 1488-1094 54.9 µM -0.549300629259144 0.277182247054731 no 2432 0.291399577801299 3411 3449522 SGTC_1703 st026983 48.3 µM -0.551706394343486 0.276311903391207 no 2433 0.290574764140761 3484 1104023 SGTC_2027 5150920 200 µM -0.553893474132043 0.27552183965095 no 2434 0.289825875760145 3388 786715 SGTC_228 caffeine 993.056 µM -0.55423955733037 0.275396921970102 no 2435 0.289707454790512 3461 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2756 carbadox 75.1 µM -0.554439083159595 0.275324916393462 no 2436 0.289639192389156 3390 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_445 e6 berbamine 66 µM -0.555719631858452 0.274863008193032 no 2437 0.289201266887223 3445 6610268 A calcium/calmodulin antagonist. SGTC_2358 9037157 4 µM -0.557583887574649 0.274191233860642 no 2438 0.288564280714353 3432 2388925 SGTC_1284 0929-0043 16 µM -0.558186371862259 0.27397430546361 no 2439 0.288358562954044 3397 1239883 SGTC_3167 9103034 49.47 µM -0.559008573609726 0.273678403296852 no 2440 0.288077934468529 3454 5127859 SGTC_730 1436-0052 41.2 µM -0.559089605606932 0.273649249254329 no 2441 0.288050284139486 3469 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2233 sulbentine 40.3845 µM -0.559462688548212 0.27351503968628 no 2442 0.287922994219909 3434 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1631 benzylvanillin 81.9 µM -0.560153475801208 0.273266628010144 no 2443 0.287687378822826 3447 75506 SGTC_1150 3909-7983 10.9 µM -0.560705684439397 0.273068130532215 no 2444 0.287499095711095 3382 23965914 SGTC_87 0100-0052 35.5 µM -0.560730420399995 0.273059240591352 no 2445 0.28749066300963 3519 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1664 st014217 9.02 µM -0.561179527755397 0.272897859325665 no 2446 0.28733757879726 3517 3982782 SGTC_118 0083-0097 135.343 µM -0.561282097609924 0.272861008732091 no 2447 0.287302621909359 3533 5207356 SGTC_3204 9114183 49.47 µM -0.56153944427693 0.27276856185309 no 2448 0.287214924311125 3391 17027248 SGTC_3152 9099253 49.47 µM -0.562474769815409 0.272432694932385 no 2449 0.286896294460608 3466 25236131 SGTC_103 0844-0104 51.839 µM -0.563005134985158 0.272242336904889 no 2450 0.2867156936552 3520 5375804 SGTC_3125 9127534 49.47 µM -0.563778799128638 0.271964772891408 no 2451 0.286452340993815 3391 1639235 SGTC_1678 st019265 80.2 µM -0.564372950147215 0.271751707591565 no 2452 0.28625017195209 3521 5367020 SGTC_1812 st052057 4.327 µM -0.564964017673835 0.271539830510551 no 2453 0.286049119369728 3422 3645418 SGTC_889 0919-1524 82.7 µM -0.566268353186267 0.27107256303846 no 2454 0.285605685097576 3419 3905452 SGTC_2402 5553605 200 µM -0.566731288890801 0.270906816609507 no 2455 0.285448379780054 3517 6758546 SGTC_1800 st050079 29.0735 µM -0.567190715234401 0.270742376662969 no 2456 0.285292307738732 3439 3645560 SGTC_1967 st070177 51.4 µM -0.568710901194299 0.270198620360135 no 2457 0.284776174322998 3510 5729214 SGTC_3122 9126309 49.47 µM -0.569016235623415 0.270089470991651 no 2458 0.284672560966085 3484 17591206 SGTC_2001 4023502 57.655 µM -0.570080619979877 0.269709152945226 no 2459 0.284311509479225 3440 108941 YCR052W RSC6 SGTC_438 sphingosine 6.67 µM -0.570325774305623 0.26962159421148 no 2460 0.284228381317393 3310 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1515 3460-0031 42.1 µM -0.571262358825459 0.269287217103418 no 2461 0.283910906570599 3429 2876596 SGTC_985 1493-0307 8.71 µM -0.571764999940427 0.269107851200721 no 2462 0.283740595951128 3505 3278274 SGTC_2320 7373003 200 µM -0.572632631667002 0.268798380663433 no 2463 0.28344673019543 3444 5415828 SGTC_520 3584-0023 682 µM -0.573555369203287 0.268469451010142 no 2464 0.283134360342758 3399 1340790 SGTC_541 4513-1321 94 µM -0.574553687893147 0.268113806888476 no 2465 0.282796590511153 3401 747515 SGTC_1687 st020778 55.3625 µM -0.574652853153534 0.268078492902349 no 2466 0.282763049638896 3472 4259299 SGTC_202 3594-0513 34.79 µM -0.575162161696213 0.267897158678006 no 2467 0.28259081527233 3444 708429 SGTC_874 0599-0792 117 µM -0.576003699132764 0.267597673100761 no 2468 0.282306340637468 3530 765305 SGTC_2649 anisomycin 9.56 µM -0.577140100668442 0.267193519575132 no 2469 0.281922408483605 3469 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3320 9137005 35.139 µM -0.577233275413188 0.267160396277752 no 2470 0.281890940647883 3431 4908713 SGTC_679 0422-0091 41.4 µM -0.578438769935917 0.266732034146098 no 2471 0.281483962559964 3460 627384 YHR062C RPP1 SGTC_2665 lovastatin 100 µM -0.579778195505324 0.266256488256973 no 2472 0.281032101735825 3490 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_927 2425-1185 123 µM -0.58000327529877 0.266176618696789 no 2473 0.280956204534558 3415 730375 SGTC_2264 7948757 110.76 µM -0.580331164659942 0.266060288873967 no 2474 0.280845657542259 3420 2971411 SGTC_771 0250-0039 27.3 µM -0.580965210605742 0.265835412725996 no 2475 0.280631950371222 3399 3005115 SGTC_2305 7443522 69.23 µM -0.582347495540661 0.265345493897409 no 2476 0.280166319817541 3461 5415886 SGTC_2250 alverine citrate 130 µM -0.585626657066619 0.264185107128929 no 2477 0.279063215318753 3455 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3088 9117578 49.47 µM -0.58571587029001 0.264153573674047 no 2478 0.279033233674837 3524 678341 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.58611019596252 0.264014217632762 no 2479 0.278900732492433 3461 5106787 A p450 inhibitor. SGTC_139 0099-0334 718.624 µM -0.586307597969479 0.263944469162953 no 2480 0.278834413035368 3514 97690 SGTC_1761 st044296 37 µM -0.58714223317194 0.263649669577092 no 2481 0.278554092664547 3484 1826700 SGTC_2268 7933382 153.85 µM -0.58952384704989 0.262809389692147 no 2482 0.277754959923408 3542 935025 YOR257W CDC31 SGTC_1521 st012942 49.4 µM -0.590691782306304 0.262397820423214 no 2483 0.277363477529336 3508 24207259 SGTC_2900 5328528 85.29 µM -0.593117175447574 0.261544190532088 no 2484 0.27655136837159 3525 795359 SGTC_2794 7785382 27.27 µM -0.594077729530612 0.261206512987384 no 2485 0.27623006275015 3512 2205081 SGTC_2824 7998404 51.95 µM -0.594792438355336 0.260955406439541 no 2486 0.275991111360628 3460 837851 SGTC_1028 k015-0029 4.8 µM -0.595282095521577 0.26078344146259 no 2487 0.275827460989082 3515 4588309 SGTC_579 4491-1009 110 µM -0.59654635286302 0.26033971080894 no 2488 0.275405148857281 3621 1271041 SGTC_647 0140-0236 81 µM -0.597380167333358 0.26004727055072 no 2489 0.275126795938335 3514 990837 SGTC_1206 3978-0017 132 µM -0.598386207032711 0.259694652063431 no 2490 0.274791133469036 3583 3873677 SGTC_1930 st074634 34.3 µM -0.601144552782658 0.258729115058167 no 2491 0.273871855614216 3495 684253 YOR116C RPO31 SGTC_2809 7964133 12.99 µM -0.6018760116135 0.258473385761581 no 2492 0.273628336586707 3480 1253665 SGTC_3031 9088762 49.47 µM -0.602086838467492 0.258399701754087 no 2493 0.273558167500475 3470 205253 SGTC_2480 5767542 37.17 µM -0.602304743783895 0.25832355526188 no 2494 0.273485651863565 3512 2867358 SGTC_1611 st001856 99.4 µM -0.602714892589261 0.258180261290072 no 2495 0.273349186278934 3468 647478 SGTC_3349 9149703 23.001 µM -0.603242543447928 0.257995976170199 no 2496 0.273173674772465 3520 4910494 SGTC_7 0192-1582 4.227 µM -0.60365757924673 0.257851070468273 no 2497 0.273035661445508 3550 252616 SGTC_3166 9102297 49.47 µM -0.604872356254774 0.257427185762805 no 2498 0.272631906082036 3487 25237072 SGTC_1314 1222-0010 41.1 µM -0.606651834381878 0.256806908301722 no 2499 0.272040996544753 3503 3526027 SGTC_1205 4161-2785 76 µM -0.610431488204371 0.255492009770587 no 2500 0.270788007366374 3494 3498106 SGTC_1965 Pectolinarigenin 58.4 µM -0.611972376201281 0.254956963461218 no 2501 0.270278017092627 3497 5320438 An anti-inflammatory. SGTC_2903 5923464 63.88 µM -0.612090369551509 0.254916016522128 no 2502 0.270238984440314 3563 2876576 SGTC_747 3448-8087 38.7 µM -0.612215993133884 0.254872425465336 no 2503 0.270197430776251 3507 5168703 SGTC_2396 5342950 42.78 µM -0.612818551806584 0.25466339341944 no 2504 0.269998161352846 3514 1886677 SGTC_1497 4476-2978 41.3 µM -0.612908780651762 0.25463210009826 no 2505 0.269968328515919 3553 1528379 SGTC_574 1315-0397 40 µM -0.613856032717569 0.254303694126527 no 2506 0.26965523319439 3586 6794277 SGTC_2284 7945075 39.21 µM -0.613878157250541 0.254296026353062 no 2507 0.269647922544722 3560 1245402 SGTC_2110 5483698 200 µM -0.61618400764199 0.253497545127771 no 2508 0.268886541054363 3517 2848765 YHR062C RPP1 SGTC_1904 st060225 78 µM -0.616513685780966 0.253383490295781 no 2509 0.268777771076712 3537 66595 SGTC_2779 methotrexate 400 µM -0.619411212569665 0.252382228773317 no 2510 0.267822748217165 3602 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2511 berberine 10.47 µM -0.620526954494415 0.251997232897424 no 2511 0.26745545684283 3542 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_957 1187-1561 14.1 µM -0.621623506078576 0.251619160968786 no 2512 0.267094730424771 3537 1538454 SGTC_753 1322-0200 289 µM -0.622748904369433 0.251231454972514 no 2513 0.266724770057001 3595 5403907 SGTC_1417 3966-0327 90.4 µM -0.622897488978353 0.251180290362994 no 2514 0.266675944120756 3570 651118 SGTC_1161 k007-0610 110 µM -0.623793552834007 0.250871850660732 no 2515 0.266381587124105 3609 5843850 SGTC_2266 7929956 200 µM -0.624605288970177 0.250592611097164 no 2516 0.266115073777503 3562 2967153 SGTC_412 gemfibrozil 100 µM -0.627972347249106 0.249436093607923 no 2517 0.265011027586402 3548 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_426 0988-0037 14.6 µM -0.62798661380165 0.249431199373481 no 2518 0.265006354591525 3588 5383008 SGTC_2369 9071472 200 µM -0.628009466289083 0.249423359784105 no 2519 0.264998869369588 3566 17296037 SGTC_2560 caryophyllene 100 µM -0.632819170474983 0.247776299891167 no 2520 0.263425868208862 3592 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1885 st057546 99.9 µM -0.632989970522722 0.247717917201337 no 2521 0.263370096265865 3617 702008 SGTC_123 0083-0120 66.675 µM -0.633110870643599 0.247676595691868 no 2522 0.26333062196669 3502 16001701 SGTC_3217 9129673 49.47 µM -0.633180500978388 0.247652798953434 no 2523 0.26330788879754 3573 17248312 SGTC_2104 5389443 200 µM -0.633425463695134 0.247569090640184 no 2524 0.263227920429739 3616 2244536 SGTC_1675 st018485 24.5 µM -0.636623760729556 0.246477561458124 no 2525 0.262184972162523 3535 3323024 SGTC_1215 3852-0577 11.2 µM -0.636941152119217 0.246369381522597 no 2526 0.262081588060723 3628 2884876 SGTC_3309 9129340 25.759 µM -0.636980309566834 0.246356036830525 no 2527 0.262068834728125 3577 17158987 SGTC_728 3030-5151 22.5 µM -0.637034319619434 0.246337631069424 no 2528 0.262051244518151 3604 3125388 SGTC_2386 9075165 157.42 µM -0.637109619269675 0.2463119713846 no 2529 0.262026721636922 3535 16452277 SGTC_2962 9082311 13.18 µM -0.637574775546642 0.246153492942391 no 2530 0.26187526000295 3537 16459453 SGTC_429 1112-0049 25.5 µM -0.6381654624426 0.245952325137846 no 2531 0.261682988509048 3525 2836170 SGTC_510 ag-490 170 µM -0.639216676049882 0.245594535955805 no 2532 0.261340992560468 3669 5328779 SGTC_55 0767-0285 6.563 µM -0.639606538395974 0.24546191420632 no 2533 0.261214215314284 3557 3116166 SGTC_3327 9140648 26.9345 µM -0.640444132933348 0.245177114977894 no 2534 0.260941949357147 3572 8029710 SGTC_836 0330-0104 1.35 µM -0.640933328540643 0.245010860724092 no 2535 0.260783000442276 3586 46494820 SGTC_1932 st074806 40.9 µM -0.641545393430953 0.244802934503532 no 2536 0.260584199147854 3680 17251235 SGTC_2679 rapamycin 1 nM -0.641848348936735 0.244700051821477 no 2537 0.260485826777414 3582 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2969 9091408 28.7 µM -0.642840108108419 0.244363416618839 no 2538 0.26016392749918 3500 4286311 SGTC_2236 dapsone 200 µM -0.642995276130226 0.244310770152116 no 2539 0.26011358254354 3602 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_198 3454-2873 16.191 µM -0.643483252428434 0.244145246070927 no 2540 0.259955289199288 3558 710957 SGTC_2485 5633444 17.78 µM -0.643760807701639 0.244051124875779 no 2541 0.259865275947444 3570 5724239 SGTC_507 nimesulide 162 µM -0.644897786474491 0.243665770732618 no 2542 0.259496713140015 3636 4495 A COX2 inhibitor. SGTC_681 1642-0006 26.6 µM -0.645738451729086 0.24338105699024 no 2543 0.259224376959653 3601 4446530 SGTC_1118 chelidonine 707.474 nM -0.646749872442924 0.243038750733562 no 2544 0.258896919893012 3597 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2256 7954252 200 µM -0.646788859555172 0.24302556110969 no 2545 0.258884301729851 3545 2972920 SGTC_3006 9075424 71.4286 µM -0.647150346784278 0.242903285787499 no 2546 0.258767321687344 3556 7465181 SGTC_169 k015-0017 16.025 µM -0.647486407220563 0.242789641100955 no 2547 0.258658594493397 3643 1840002 SGTC_1275 0867-0008 21.1 µM -0.647980820058355 0.242622499117502 no 2548 0.258498677815575 3552 3422836 SGTC_3226 9131256 49.47 µM -0.648821699782757 0.242338373141609 no 2549 0.258226814890442 3516 17178073 SGTC_3220 9131269 49.47 µM -0.64889780516511 0.242312666692671 no 2550 0.258202216747075 3626 17722206 SGTC_1091 telmisartan 47.6 µM -0.650388668397169 0.241809389413697 no 2551 0.257720597514822 3661 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2409 alverine citrate 63.97 µM -0.651757462664122 0.241347819417959 no 2552 0.257278823316646 3673 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_601 0986-0029 62.9 µM -0.652533153456088 0.241086462015418 no 2553 0.257028646314034 3604 24747981 SGTC_2184 6075246 200 µM -0.654551305193814 0.24040719758189 no 2554 0.256378342254742 3599 2267320 SGTC_950 1165-0508 94.1 µM -0.655542432386502 0.240073988561777 no 2555 0.256059288015538 3571 6148369 SGTC_745 0469-0705 296 µM -0.656640710527681 0.239705050525045 no 2556 0.255705982816719 3685 3486736 SGTC_3355 9151058 44.0485 µM -0.656785796066687 0.239656335950342 no 2557 0.255659329276637 3615 17015728 SGTC_1833 st055984 71 µM -0.656978394586177 0.239591676551178 no 2558 0.255597404384428 3610 676288 SGTC_1849 st056239 19.2 µM -0.657188154240585 0.23952126663056 no 2559 0.255529970702602 3520 5393181 SGTC_905 2-aminofluorene 215 µM -0.658530878971628 0.239070822602466 no 2560 0.255098530870363 3651 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2306 7482397 179.52 µM -0.65945047342789 0.238762593499695 no 2561 0.254803269827637 3618 891448 SGTC_29 0299-0004 12.984 µM -0.660926634751086 0.238268269575308 no 2562 0.254329682062805 3515 16871 A napthoquinone isolated from Swertia calycina. SGTC_591 4299-0174 154 µM -0.661369445951223 0.238120094237857 no 2563 0.254187707686753 3567 5509088 SGTC_2727 riluzole 51.77 µM -0.661978495370368 0.237916374089936 no 2564 0.253992501835577 3602 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2557 derrustone 83.84 µM -0.662762397417821 0.237654308427216 no 2565 0.253741369955101 3619 629853 An antioxidant. SGTC_2234 tolnaftate 200 µM -0.662822486309316 0.237634226695969 no 2566 0.253722125181031 3596 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3109 9122853 49.47 µM -0.663402218455581 0.237440527817542 no 2567 0.253536492731094 3646 1234709 SGTC_2242 6630449 61.2675 µM -0.664183713000809 0.237179553745357 no 2568 0.253286368161573 3600 691249 YDR170C SEC7 SGTC_2904 7225135 42.03 µM -0.664393175798946 0.237109632047791 no 2569 0.253219349705438 3688 4446116 SGTC_1477 0139-0234 16 µM -0.664598284032916 0.237041174943279 no 2570 0.253153733546645 3623 620880 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.665724036404153 0.236665636321529 no 2571 0.252793753494804 3600 15053 SGTC_764 1951-2361 146 µM -0.665727528869832 0.236664471782826 no 2572 0.252792637134078 3597 5438930 SGTC_2822 7994718 71.43 µM -0.666145112906711 0.236525253975887 no 2573 0.252659175816353 3587 1018011 SGTC_1789 tunicamycin 25 nM -0.669272251183686 0.235484135089168 no 2574 0.251660912210287 3619 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_6 0844-0013 19.835 µM -0.670545729413104 0.235060881369769 no 2575 0.251254982668924 3721 1584900 SGTC_1425 4048-4433 7.33 µM -0.670929365951712 0.234933458197655 no 2576 0.251132763900243 3679 23734946 SGTC_2895 9054447 58.44 µM -0.67114296135382 0.234862529978914 no 2577 0.251064730396875 3657 2697450 SGTC_1942 st076330 65.2 µM -0.671590981596797 0.234713795204052 no 2578 0.250922060567723 3670 24208414 SGTC_839 0122-0028 230 µM -0.672614789979141 0.234374104545882 no 2579 0.250596194989439 3638 759448 SGTC_3057 9095946 49.47 µM -0.672842585117384 0.234298561130693 no 2580 0.250523721108746 3650 24540043 SGTC_2471 5466956 24.79 µM -0.6729181356572 0.234273509376701 no 2581 0.250499686872819 3591 724419 SGTC_3272 9137413 49.47 µM -0.672925792869946 0.234270970409299 no 2582 0.250497251018541 3593 17614870 SGTC_1925 st057770 10.1 µM -0.672964795608651 0.234258038174635 no 2583 0.250484843958743 3571 5989122 SGTC_1596 piperlongumine 63 µM -0.673065686907464 0.234224587230167 no 2584 0.250452751200751 3648 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1299 1079-1439 3.74 µM -0.673196645860092 0.234181171169853 no 2585 0.250411097400031 3603 323161 SGTC_66 0109-0187 42.4 µM -0.674490759476595 0.23375238085855 no 2586 0.249999679274407 3629 759417 SGTC_519 k048-0011 62.8 µM -0.67460382866607 0.233714937309994 no 2587 0.249963749929513 3633 6836379 SGTC_409 arachidonic acid 100 µM -0.675619563445486 0.233378719705002 no 2588 0.249641108657683 3663 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1934 st074720 32.6 µM -0.675753718554465 0.233334333194332 no 2589 0.249598511739472 3638 17250992 SGTC_2270 7924575 90.91 µM -0.676207357014645 0.23318427724386 no 2590 0.249454501103757 3624 1262135 SGTC_2136 5328288 199.296 µM -0.67968432014593 0.232035936964862 no 2591 0.248352183182474 3622 262395 SGTC_2662 daunorubicin 22.37 µM -0.680345968263411 0.231817770866148 no 2592 0.248142712240313 3568 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_91 0417-1751 58.384 µM -0.683290642915247 0.230848206643958 no 2593 0.247211602831622 3730 6795624 SGTC_67 0335-0847 266 µM -0.683714337683373 0.230708887408998 no 2594 0.247077783991592 3722 4552207 YOR254C SEC63 SGTC_1170 0310-0127 64.8 µM -0.683746935840175 0.230698170435397 no 2595 0.247067489865791 3636 774975 SGTC_719 2810-4230 27.3 µM -0.685354939878555 0.230169868198502 no 2596 0.246559985467507 3629 721079 SGTC_1957 st077035 62.4 µM -0.68796934248177 0.229312364867198 no 2597 0.245736043772759 3716 705593 SGTC_2713 st079149 53.4 µM -0.688726965784121 0.229064205547035 no 2598 0.245497551678247 3684 3103253 SGTC_2928 9011484 9.79 µM -0.689071465349384 0.228951414647481 no 2599 0.245389147869101 3662 2994751 SGTC_1016 4226-1401 38 µM -0.689720264607413 0.228739079127513 no 2600 0.245185059825409 3653 2901613 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.691201702778747 0.228254656722198 no 2601 0.24471939697921 3618 641818 YHR062C RPP1 SGTC_37 0566-0070 1.56 µM -0.691420558454888 0.228183141002324 no 2602 0.244650644113027 3678 1626686 SGTC_481 bay k-8644 50 µM -0.69158829043323 0.228128339560095 no 2603 0.24459795864755 3627 2303 A calcium channel antagonist. SGTC_824 1304-0008 100 µM -0.691935918362571 0.228014786025426 no 2604 0.244488786409696 3677 768245 SGTC_1176 0848-0131 83.3 µM -0.69356479943739 0.227483131639336 no 2605 0.243977587648194 3734 6769040 SGTC_516 3992-2719 87.3 µM -0.693614981170893 0.227466763797022 no 2606 0.243961848059918 3637 5350887 YDR037W KRS1 SGTC_3193 9111931 49.47 µM -0.696406193810538 0.226557395476532 no 2607 0.243087242619984 3708 17087244 SGTC_1847 st056231 15 µM -0.697037011430338 0.226352161769439 no 2608 0.242889815846257 3680 5393180 SGTC_2097 5376186 200 µM -0.697365742426468 0.226245252235177 no 2609 0.242786967415349 3636 742755 SGTC_1202 1988-0068 29.6 µM -0.697825557331584 0.226095759606694 no 2610 0.242643146965543 3618 2850480 SGTC_549 1661-1316 519 µM -0.697959842515711 0.226052112041604 no 2611 0.242601154083266 3697 2857282 SGTC_176 1486-1328 72.834 µM -0.698135308706539 0.22599508633103 no 2612 0.242546289247078 3682 22310231 SGTC_1397 3532-0190 20.1 µM -0.701020361895673 0.225058624172645 no 2613 0.241645154020709 3606 5322280 SGTC_3035 9091303 49.47 µM -0.701026351784066 0.225056682199162 no 2614 0.241643284994833 3705 25237002 SGTC_1908 st060353 56.5 µM -0.701181431598309 0.225006407291092 no 2615 0.241594898146516 3709 4227716 SGTC_1423 4048-0112 5.59 µM -0.701851004498067 0.224789413331916 no 2616 0.241386043403407 3679 X1423 SGTC_2975 9084847 53.72 µM -0.702645017219416 0.22453224499898 no 2617 0.241138500280185 3714 27211724 SGTC_154 3389-1638 511.116 µM -0.703055883923102 0.224399237249616 no 2618 0.241010461789747 3606 5238686 SGTC_1708 st033234 31.827 µM -0.703196921938859 0.224353590055704 no 2619 0.240966518604004 3749 674664 SGTC_2020 4017018 200 µM -0.704122528648619 0.2240541467048 no 2620 0.240678235681071 3733 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_211 3455-0679 143.504 µM -0.704884900829926 0.223807682012651 no 2621 0.240440933684783 3705 748649 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.707212540714799 0.223056141550014 no 2622 0.239717203200509 3731 1377 SGTC_2401 5128683 200 µM -0.709332000715048 0.222373069334584 no 2623 0.2390592372473 3653 708373 SGTC_371 0195-0006 7.36 µM -0.710959531730714 0.221849349845725 no 2624 0.23855465677374 3596 3928593 SGTC_2817 7995342 71.43 µM -0.711296197519811 0.221741102933007 no 2625 0.238450353707582 3681 18879975 SGTC_1276 0871-0068 94.2 µM -0.712912464152884 0.221221851021313 no 2626 0.237949962931501 3683 3414906 SGTC_472 calcifediol 10 µM -0.712970140291823 0.221203334487079 no 2627 0.237932117235337 3713 5283731 A vitamin D metabolite. SGTC_575 k072-0246 11.9 µM -0.713307743345962 0.221094967095709 no 2628 0.237827673480154 3719 6796779 SGTC_1695 st026914 34.495 µM -0.715212170116872 0.220484233400902 no 2629 0.237238975029338 3665 3289191 SGTC_503 tyrphostin 8 294 µM -0.715558528825438 0.220373263063863 no 2630 0.237131994341227 3665 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_324 1315-0088 19.6 µM -0.719200567081236 0.219208325404711 no 2631 0.23600867502673 3643 6787421 SGTC_2957 9076800 11.52 µM -0.719343634557946 0.219162636402638 no 2632 0.235964608446689 3663 16459615 SGTC_2185 6113692 200 µM -0.722894171852795 0.21803051745935 no 2633 0.23487245223172 3694 874150 SGTC_3346 9158254 43.5805 µM -0.722944690866294 0.218014433407543 no 2634 0.234856932612418 3706 17639500 SGTC_5 0352-0601 109.883 µM -0.72296936466042 0.218006578107241 no 2635 0.234849352941769 3631 762456 SGTC_1705 st027868 56.3335 µM -0.72449813930108 0.217520186408125 no 2636 0.234379984545326 3724 292948 SGTC_1820 st053765 18.6 µM -0.724647687642976 0.217472640081612 no 2637 0.234334097712444 3699 3690829 SGTC_1229 0139-0193 12.2 µM -0.724984216367443 0.217365668497569 no 2638 0.234230856730062 3740 3090752 SGTC_21 0849-0113 22.993 µM -0.725415694469343 0.217228560041253 no 2639 0.234098523827621 3682 1560156 SGTC_2681 menadione 3.18 µM -0.72545833430156 0.217215013325794 no 2640 0.234085448580883 3734 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3296 9122258 64.045 µM -0.725886740852789 0.217078935238139 no 2641 0.233954102749613 3747 4730474 SGTC_105 0111-0055 734.78 µM -0.726161159934612 0.216991795269995 no 2642 0.233869989633728 3724 5179370 SGTC_1935 st074532 41.6 µM -0.72668326247034 0.216826060888402 no 2643 0.233710004508409 3760 2829742 SGTC_1155 4088-0394 48.2 µM -0.7271775018077 0.216669238756406 no 2644 0.233558613271309 3687 2326248 SGTC_860 0443-0016 25.1 µM -0.728004251723396 0.216407057731008 no 2645 0.233305491809099 3745 5337942 SGTC_15 0266-0086 27.098 µM -0.728117679979112 0.216371101404584 no 2646 0.233270775984949 3798 1712902 YIL048W NEO1 SGTC_187 1488-2104 32.728 µM -0.728269566079496 0.216322959503041 no 2647 0.233224294252242 3762 2852859 SGTC_2857 9024691 58.44 µM -0.729423222255073 0.21595749847323 no 2648 0.232871408495632 3787 16478292 SGTC_1445 4239-0156 97.7 µM -0.730256404284057 0.215693781472053 no 2649 0.232616735457954 3793 4008346 SGTC_393 acivicin 6.25 µM -0.731141220648459 0.21541392580119 no 2650 0.232346449311375 3625 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_291 SEC14.278 35.5 µM -0.731695945733177 0.215238581101984 no 2651 0.232177085769976 3715 1068044 SGTC_1694 st024011 44.9 µM -0.734072160307781 0.214488414399034 no 2652 0.231452379936281 3776 2787533 SGTC_765 1319-0117 244 µM -0.734985066562606 0.214200616202072 no 2653 0.23117429446809 3698 3487746 YGL099W LSG1 SGTC_1474 0330-0125 5.35 µM -0.737389085660991 0.213443813050777 no 2654 0.230442885409417 3738 X1474 SGTC_1480 1070-0044 41.2 µM -0.737762367490906 0.213326441089639 no 2655 0.230329432688034 3746 3124987 SGTC_1966 st070145 16.1 µM -0.737987178074584 0.21325577148175 no 2656 0.230261120371994 3701 3748532 SGTC_2923 7992654 58.14 µM -0.73836966272702 0.213135568125271 no 2657 0.230144922294212 3766 2985126 SGTC_2463 5473429 200 µM -0.739405977373637 0.212810084442068 no 2658 0.229830256869422 3735 5399405 SGTC_2429 5902844 64.44 µM -0.739747377482243 0.212702921731933 no 2659 0.229726647292988 3774 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_578 3460-0051 92 µM -0.740226964433389 0.212552436530108 no 2660 0.2295811443707 3810 2876744 SGTC_3172 9105863 49.47 µM -0.740570583311059 0.212444653756219 no 2661 0.229476924852992 3716 2348785 SGTC_592 k241-0073 46.5 µM -0.741104961089033 0.212277099184395 no 2662 0.229314900897567 3734 4230158 SGTC_1578 josamycin 24.2 µM -0.742558406127583 0.211821761269337 no 2663 0.22887453929654 3716 5282165 A P450 substrate. SGTC_857 0438-0306 1.35 µM -0.743895634450205 0.211403337133639 no 2664 0.228469808329903 3799 4686136 SGTC_2036 5160441 105 µM -0.744596609221519 0.211184192826158 no 2665 0.228257809191707 3740 134534 YIL048W NEO1 SGTC_701 4424-0219 185 µM -0.745848356217822 0.210793192990274 no 2666 0.227879512564857 3759 2911779 SGTC_2814 7977482 42.97 µM -0.747070087179273 0.210411978814545 no 2667 0.227510627651512 3831 6456762 SGTC_26 0302-0163 425.158 µM -0.748263671120668 0.21003993842062 no 2668 0.227150566337026 3787 3100915 SGTC_1367 1812-0510 76.9 µM -0.749528736137591 0.209646039589306 no 2669 0.226769292643775 3780 1142582 YDR527W RBA50 SGTC_2692 st077426 47.7 µM -0.75002747892695 0.209490867279125 no 2670 0.226619077528638 3737 25238571 SGTC_3252 9135871 49.47 µM -0.751031621676848 0.209178656478078 no 2671 0.226316812679537 3765 17682838 SGTC_287 k060-0039 29.6 µM -0.75108232437874 0.209162899124392 no 2672 0.226301556305592 3780 5861974 SGTC_2031 5180455 200 µM -0.751214379782399 0.209121862309932 no 2673 0.226261823741635 3738 29949 SGTC_3106 9121286 49.47 µM -0.752092106369356 0.208849225294447 no 2674 0.225997835306817 3752 15943471 SGTC_641 4092-0595 30 µM -0.754852899120376 0.207993041886724 no 2675 0.225168624785154 3809 786260 SGTC_2635 hydroquinidine 100 µM -0.755343597889864 0.207841082423653 no 2676 0.225021422870192 3728 442912 An experimental heart treatment. SGTC_2845 9003024 42.97 µM -0.755751718610394 0.207714745666182 no 2677 0.224899034622955 3768 2990173 SGTC_373 0844-0104 25.9 µM -0.756261143075958 0.207557113263235 no 2678 0.224746320119158 3811 5375804 SGTC_2022 5136654 200 µM -0.75660064073666 0.207452100974721 no 2679 0.224644578681075 3790 1713771 SGTC_125 0133-0007 11.75 µM -0.760400730177124 0.206278814609228 no 2680 0.223507543484694 3847 26541 SGTC_521 r062-0005 13.8 µM -0.762961359961259 0.205490437003328 no 2681 0.222743220189023 3699 2832033 SGTC_1328 1441-0025 69.2 µM -0.763076879300764 0.205454912645448 no 2682 0.222708773932219 3730 4562601 SGTC_1449 4112-4002 201 µM -0.764845064310618 0.204911617933412 no 2683 0.222181904842731 3796 2059539 SGTC_1300 1094-0077 113 µM -0.765903182211222 0.204586908247591 no 2684 0.221866956159037 3740 5532636 SGTC_707 0865-0008 204 µM -0.767157787642521 0.204202298480377 no 2685 0.22149385359504 3776 723043 SGTC_1500 4488-1866 171 µM -0.767534061066729 0.20408703271179 no 2686 0.221382024960401 3867 2900003 SGTC_1225 1216-0074 20.6 µM -0.767676420424498 0.204043433147119 no 2687 0.221339724113254 3784 4241466 SGTC_2442 5158906 48.48 µM -0.767823582063091 0.203998368649539 no 2688 0.221296001169232 3799 1893835 SGTC_2436 5633522 8.09 µM -0.768134122484398 0.203903293029695 no 2689 0.221203753245045 3749 5724242 SGTC_2068 5226020 147 µM -0.768252389481356 0.203867091135523 no 2690 0.221168627098049 3831 1810509 SGTC_3294 9122953 26.2835 µM -0.769221309799927 0.203570645900813 no 2691 0.220880971001697 3784 16459826 SGTC_1020 4335-0961 93.3 µM -0.771032835830704 0.203017092049667 no 2692 0.220343734485717 3737 669075 SGTC_1380 2291-0730 164 µM -0.773844198472598 0.2021597970014 no 2693 0.219511465845729 3825 2999191 SGTC_2086 5274770 176.623 µM -0.774363277516964 0.202001746594876 no 2694 0.219357996731498 3849 689278 SGTC_1199 1638-0010 4.46 µM -0.775525868252972 0.201648026662767 no 2695 0.219014492961905 3775 3111136 SGTC_1564 D-Arginine 115 µM -0.775801994350422 0.201564069450656 no 2696 0.218932953113799 3786 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_417 st075190 100 µM -0.779066294687402 0.200573134356265 no 2697 0.21797033180486 3794 222757 SGTC_1444 4112-3581 28 µM -0.779180762484123 0.200538438838598 no 2698 0.217936620330588 3819 2877249 SGTC_3287 9117173 37.0625 µM -0.780069567978112 0.200269162001079 no 2699 0.217674963935365 3785 2789709 SGTC_1394 3474-0001 65.7 µM -0.780149162305417 0.200245058320293 no 2700 0.21765154092282 3802 5017666 YIL048W NEO1 SGTC_562 3772-2733 112 µM -0.781599645012287 0.199806111674539 no 2701 0.217224947794988 3838 2876874 YIL048W NEO1 SGTC_1168 k815-0004 80.5 µM -0.782404348464442 0.199562841253638 no 2702 0.216988489530229 3780 642433 SGTC_1078 idebenone 36.1 µM -0.783486748973184 0.199235901344538 no 2703 0.216670666052033 3870 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1774 st048371 48.465 µM -0.783559737642245 0.199213866676718 no 2704 0.21664924420392 3785 4242727 SGTC_3255 9139072 49.47 µM -0.784913528246089 0.198805434775859 no 2705 0.216252134855081 3810 17646060 SGTC_3053 9095903 49.47 µM -0.785260257664107 0.198700909491872 no 2706 0.216150496045047 3884 17174018 SGTC_1065 prochlorperazine maleate 2.48 µM -0.786159591742411 0.198429950123849 no 2707 0.215886997989805 3844 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1362 1611-0397 101 µM -0.786655304367424 0.198280692771999 no 2708 0.215741837566354 3787 27816 SGTC_3347 9188721 44.724 µM -0.78717557424336 0.198124114219607 no 2709 0.215589546868947 3855 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1253 0550-0034 176 µM -0.789602423910486 0.197394725102413 no 2710 0.21487999611493 3835 5969915 SGTC_62 0180-0423 3.232 µM -0.790750714952942 0.197050173198778 no 2711 0.214544737571106 3779 30102 YGL099W LSG1 SGTC_3300 9124615 50.48 µM -0.791213462365434 0.19691142590589 no 2712 0.214409718438553 3853 24824903 SGTC_833 3852-0053 558 µM -0.792251207334316 0.196600490056371 no 2713 0.21410710786477 3882 3123681 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.793783267241556 0.196141988473285 no 2714 0.213660807711678 3829 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2976 9009005 19.48 µM -0.794650121157833 0.195882851459018 no 2715 0.213408527140512 3801 2993148 SGTC_778 3456-2434 196 µM -0.79568478413775 0.195573821767689 no 2716 0.213107636511208 3861 5539063 SGTC_3331 9141060 1.957 µM -0.796185995613535 0.195424228090392 no 2717 0.212961968081457 3802 4906567 YPR165W RHO1 SGTC_642 0335-0876 158 µM -0.797838381384936 0.194931542587162 no 2718 0.21248214250494 3845 6812350 SGTC_2438 5259590 200 µM -0.799871052156542 0.194326506071699 no 2719 0.2118927556111 3858 1201127 SGTC_2056 5235370 200 µM -0.802166585180245 0.193644603566854 no 2720 0.211228301270056 3820 5511916 SGTC_3337 9144342 33.5465 µM -0.802702054192506 0.193485749264415 no 2721 0.211073482676845 3842 17682949 SGTC_351 caspofungin 25 nM -0.803821467695594 0.193153916631541 no 2722 0.210750044855589 3850 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1060 3448-7350 82 µM -0.804774255500832 0.192871751451025 no 2723 0.210474980209303 3762 570178 SGTC_2605 digitonin 300 nM -0.805345434063523 0.192702719451065 no 2724 0.210310185145365 3854 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2558 carylophyllene oxide 100 µM -0.805582852503866 0.192632485553373 no 2725 0.210241708045672 3932 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2568 diosmetin 100 µM -0.806242769577756 0.192437348921862 no 2726 0.210051441128708 3862 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2028 5153890 36.43 µM -0.80758985271558 0.192039393501885 no 2727 0.209663365061833 3810 2830968 YPR165W RHO1 SGTC_652 0437-0092 114 µM -0.808218925820965 0.191853725298646 no 2728 0.209482282298146 3795 3091274 SGTC_142 0335-0849 62.6745 µM -0.809313149106325 0.191531031967644 no 2729 0.209167522355963 3866 3889043 YPR107C YTH1 SGTC_2818 7996756 12.99 µM -0.810412117953327 0.1912072740361 no 2730 0.208851677757942 3839 2241621 SGTC_580 1123-0028 41 µM -0.812678711657373 0.190540592402402 no 2731 0.208201144888515 3920 1677248 YPR107C YTH1 SGTC_2004 4023728 41.89 µM -0.813290283976946 0.190360953137677 no 2732 0.208025823152293 3861 360084 YDR527W RBA50 SGTC_201 4262-0159 12.803 µM -0.814046617678417 0.190138936530089 no 2733 0.207809122706083 3869 1341029 SGTC_165 k038-0023 64.381 µM -0.815688927547572 0.189657395802712 no 2734 0.207339036698749 3863 46368543 SGTC_2495 cafestol 54.53 µM -0.816024269702554 0.189559162629064 no 2735 0.207243127505591 3857 16667697 An anti-infammatory. SGTC_2908 7930301 100 µM -0.818522638974747 0.188828290703718 no 2736 0.206529410211166 3867 2223178 SGTC_2517 totarol 10 µM -0.818909723616634 0.188715208688504 no 2737 0.20641896089329 3876 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_206 4546-0025 72.014 µM -0.819819993283045 0.188449449148188 no 2738 0.206159365831532 3907 6620745 YIL048W NEO1 SGTC_2163 5671233 125 µM -0.820713335419417 0.188188856258265 no 2739 0.205904786527531 3848 701023 SGTC_2760 etidronate 98.04 µM -0.820888153649909 0.188137886831765 no 2740 0.205854989699568 3852 3305 A chelator and antioxidant. SGTC_1448 4255-0083 152 µM -0.822268600442092 0.187735707634756 no 2741 0.205462021608887 3939 5399660 SGTC_671 0560-0003 407 µM -0.82346814040985 0.187386665369978 no 2742 0.205120913769445 3780 3238678 SGTC_2325 6158266 200 µM -0.823782075004235 0.187295382921445 no 2743 0.205031697182685 3913 3623240 SGTC_1096 rimcazole 32.2 µM -0.826377314530764 0.186541821177523 no 2744 0.20429504398626 3806 18528119 A dopamine reuptake inhibitor. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.82717079933071 0.186311797790002 no 2745 0.204070129971631 3826 6708514 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.828618096022441 0.185892693643304 no 2746 0.203660272456219 3892 6708784 An antioxidant flavonoid SGTC_682 0kpi-0099 17 µM -0.828691888358992 0.185871340739798 no 2747 0.203639388487784 3921 1714895 YML126C ERG13 SGTC_210 3551-0445 56.827 µM -0.829299602356546 0.185695547561294 no 2748 0.203467447923328 3894 2865180 YOR207C RET1 SGTC_648 0375-0473 33.3 µM -0.830145504686053 0.18545102551892 no 2749 0.203228260940069 3863 1713139 SGTC_912 3474-0017 2.18 µM -0.831099709776055 0.185175436779143 no 2750 0.202958651842114 3909 3360550 SGTC_2753 fluvastatin 17.09 µM -0.831263202728063 0.185128243099854 no 2751 0.202912478619071 3927 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2153 5569715 200 µM -0.831929817138933 0.184935896326641 no 2752 0.202724280192346 3893 2054701 SGTC_2947 9072639 7.68 µM -0.832036647661389 0.184905082700617 no 2753 0.202694129523899 3919 16488146 SGTC_624 k048-0052 28 µM -0.832366981057453 0.184809823285169 no 2754 0.202600916824594 3869 6835531 SGTC_372 0155-0182 15.9 µM -0.834263594545967 0.184263480649661 no 2755 0.202066230943179 3823 771486 SGTC_484 loperamide 105 µM -0.835731103954131 0.183841437129792 no 2756 0.201653096480406 3856 3955 An opioid-receptor agonist. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.835950998856392 0.183778249090011 no 2757 0.201591235101992 3824 97141 SGTC_116 0155-0182 31.788 µM -0.837241083423632 0.183407808593141 no 2758 0.201228534382802 3821 771486 SGTC_367 0335-0881 7.1 µM -0.837899481785405 0.183218932759383 no 2759 0.201043579922654 3880 23828853 SGTC_2235 salicylic acid 500 µM -0.838729410987921 0.182981022488899 no 2760 0.200810585083973 3885 338 A COX inhibitor and kinase inhibitor. SGTC_2514 salinomycin 42.74 µM -0.839041742147941 0.182891538543313 no 2761 0.200722943026091 3969 23682228 A polyether potassium ionophore. SGTC_1107 amlodipine 47 µM -0.840046925336058 0.182603735553495 no 2762 0.200441038292187 3690 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2999 9069765 71.4286 µM -0.840658151622977 0.182428868243546 no 2763 0.200269735532855 3909 2097066 SGTC_1154 4088-0362 150 µM -0.843368926279066 0.181654597157952 no 2764 0.199511072511415 3888 6618304 SGTC_1407 3909-7909 12.3 µM -0.844083488154374 0.181450841780317 no 2765 0.199311376933334 3874 4411780 SGTC_2661 dactinomycin 12.96 µM -0.844885508026915 0.181222318473688 no 2766 0.199087383259054 3874 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2556 citropten 84.59 µM -0.845203531454585 0.181131752489263 no 2767 0.198998605478703 3939 2775 A potential DNA crosslinker. SGTC_387 norethindrone acetate 66.7 µM -0.846121948605492 0.180870366956997 no 2768 0.198742358837721 3896 541197 SGTC_1510 1123-0200 71.5 µM -0.846182873656822 0.180853035787106 no 2769 0.198725367240218 3959 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_455 paf C-16 10 µM -0.846239203415851 0.180837012752619 no 2770 0.198709658018964 3868 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2142 5622915 118.518 µM -0.847112202696634 0.180588801339757 no 2771 0.198466292059439 3913 5322196 SGTC_3099 9120367 49.47 µM -0.848291214621731 0.180253923629414 no 2772 0.198137904540189 3923 24824940 SGTC_2085 5307070 144.047 µM -0.848416953404411 0.180218232740011 no 2773 0.198102902171279 3861 2840351 SGTC_1781 st038725 66.3 µM -0.849064206137504 0.180034580569175 no 2774 0.197922783121977 3891 4270275 YIL048W NEO1 SGTC_1144 3486-0183 12.5 µM -0.849488904938236 0.179914139955773 no 2775 0.197804650684769 3894 6744069 SGTC_225 nsc-122657 1.016 µM -0.849650572879254 0.17986830573826 no 2776 0.197759693005765 3906 275685 SGTC_2304 7443016 91.4 µM -0.850435381490261 0.17964591014292 no 2777 0.197541536044706 3844 939854 SGTC_756 0508-1999 28.3 µM -0.852456958828614 0.179073840717862 no 2778 0.196980259083394 3903 6753853 SGTC_1436 4092-1007 8.32 µM -0.85554369582944 0.178202564354852 no 2779 0.196125112493035 3883 2881121 SGTC_3229 9132204 49.47 µM -0.856165215753264 0.178027455017175 no 2780 0.195953199927816 3944 17682924 SGTC_590 k048-0076 22.4 µM -0.856321908449353 0.177983324963236 no 2781 0.19590987312331 3917 6832814 SGTC_1269 0831-0796 3.05 µM -0.85688930779842 0.177823583505366 no 2782 0.195753031229139 3956 927758 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.858111857401019 0.177479703305533 no 2783 0.195415350243278 3895 688751 SGTC_792 4534-1957 155 µM -0.859526471778989 0.177082323149686 no 2784 0.195025060843477 3875 1717904 SGTC_726 3448-4391 34.2 µM -0.860533737459083 0.176799714441397 no 2785 0.194747447232994 4021 1356692 SGTC_14 0354-0009 295 µM -0.861320439491848 0.176579187719769 no 2786 0.194530790700607 3988 1713507 SGTC_2301 7769476 200 µM -0.861335051097198 0.176575093470288 no 2787 0.194526768075005 3962 977820 SGTC_389 tpck 16.7 µM -0.862565912982613 0.176230414984938 no 2788 0.194188089311903 3928 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1667 st014849 34.6 µM -0.862596373041345 0.176221890651581 no 2789 0.194179712606994 3961 5348460 SGTC_157 1348-1695 65.819 µM -0.864551269689579 0.175675353172668 no 2790 0.193642564339625 3888 5380510 SGTC_1970 st070122 35.8 µM -0.866476180401958 0.175138249548274 no 2791 0.193114541633711 3943 102928 SGTC_2111 5486399 200 µM -0.866590024234612 0.17510651660924 no 2792 0.193083340660775 3878 689674 SGTC_2531 methyl deoxycholate 70.07 µM -0.86694428917206 0.175007791796755 no 2793 0.192986267604003 3893 16667744 Haematoxylin. SGTC_315 k915-0449 187 µM -0.870748293314341 0.173949936939523 no 2794 0.19194580168308 3958 20970215 YNL149C PGA2 SGTC_2071 5230951 39.92 µM -0.870794427596082 0.173937132469803 no 2795 0.191933204208068 3952 1799272 SGTC_979 1426-2828 121 µM -0.873369664365497 0.173223331692537 no 2796 0.191230810129979 4045 747872 SGTC_2349 9023730 187.07 µM -0.873835987155542 0.173094276701133 no 2797 0.191103789617005 3944 4126287 SGTC_1605 st000082 49.1 µM -0.873870989139698 0.173084592361676 no 2798 0.191094257600818 3935 1114022 SGTC_3228 9131799 49.47 µM -0.874305691066138 0.172964347911745 no 2799 0.190975900442146 3950 17015818 SGTC_2600 tangeritin 87.95 µM -0.874947250871997 0.172786981032316 no 2800 0.190801303847623 3874 68077 A bioactive flavone. SGTC_1816 st051957 91.6 µM -0.877635291994045 0.172045100889169 no 2801 0.190070835280774 3917 674121 SGTC_2855 9016525 58.44 µM -0.880744141895107 0.171189620235843 no 2802 0.18922815954728 3904 43811474 SGTC_695 3505-6186 243 µM -0.882138958398934 0.170806685821348 no 2803 0.188850833374691 3956 1819379 SGTC_1647 st011722 22.4 µM -0.882345145831002 0.170750125444852 no 2804 0.188795094849294 3914 2854783 SGTC_2134 5324836 1.464 µM -0.884379746125372 0.17019264623405 no 2805 0.188245626327807 3916 699272 SGTC_3273 9137859 49.47 µM -0.884526332111038 0.170152526853909 no 2806 0.188206077143623 4019 2377234 SGTC_1105 epirubicin 18.1 µM -0.886045802119359 0.169737017434563 no 2807 0.18779642326283 3964 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_459 nigericin 15.3 µM -0.886531686849474 0.169604286379948 no 2808 0.187665543506598 4001 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1166 k206-0078 225 µM -0.888096196612338 0.169177355571881 no 2809 0.187244504183715 3979 5404595 SGTC_3104 9120930 49.47 µM -0.889741067475668 0.168729240216585 no 2810 0.18680246857854 3979 17014836 SGTC_2775 cyproheptadine 69.59 µM -0.890584804560248 0.168499675557604 no 2811 0.186575977089279 3965 2913 A selective serotonin reuptake inhibitor. SGTC_1273 0849-0096 14.1 µM -0.893108497750028 0.167814226386279 no 2812 0.185899536348468 3983 5286025 SGTC_2342 7990637 118.86 µM -0.893127220819542 0.167809147814182 no 2813 0.185894523581063 4031 2033102 YER133W GLC7 SGTC_1243 0416-0003 5.65 µM -0.89353942821607 0.167697362961958 no 2814 0.185784183652178 3962 2141977 SGTC_2459 5811157 9.22 µM -0.894477989659207 0.167443017237351 no 2815 0.185533100542898 3937 2870684 YBR192W RIM2 SGTC_416 estradiol valerate 100 µM -0.896877895619165 0.16679378504594 no 2816 0.184892038166609 3990 13791 A steroid. SGTC_2722 naftopidil 47.16 µM -0.897115763907217 0.166729524542289 no 2817 0.184828573906218 3870 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1252 0493-0875 34.8 µM -0.897537509324909 0.166615628610689 no 2818 0.184716083743497 3952 3960963 SGTC_347 4534-1311 26.2 µM -0.900271882057674 0.165878406575842 no 2819 0.183987790392712 3976 2862016 SGTC_2043 5101342 149 µM -0.902227158862604 0.1653525336923 no 2820 0.183468105247394 3974 678451 SGTC_2611 pyromycin 23.93 µM -0.902716140797302 0.165221190501989 no 2821 0.183338283871892 3973 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_456 gingerol 170 µM -0.905410124855039 0.164498782973978 no 2822 0.182624076914415 3984 442793 A herb. SGTC_1053 3366-3204 134 µM -0.907103220571073 0.164045818708275 no 2823 0.182176107578294 4018 3632071 YPR165W RHO1 SGTC_1773 st048542 73.5835 µM -0.907673736444246 0.163893367541025 no 2824 0.182025311940039 3916 3237138 SGTC_3171 9103192 49.47 µM -0.908462297023 0.163682802671324 no 2825 0.181817012443339 4001 13018434 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.908493465499277 0.163674483539083 no 2826 0.181808782306473 3984 688669 SGTC_534 k292-0788 63.4 µM -0.908755563524128 0.163604538199594 no 2827 0.181739583695723 3985 4146317 SGTC_2730 imipramine 71.33 µM -0.909778098584947 0.163331842822335 no 2828 0.18146977354914 3963 3696 A tricyclic antidepressant. SGTC_447 ml7 120 µM -0.909781167770836 0.163331024759388 no 2829 0.181468964079232 3998 4216 Selective myosin light chain kinase inhibitor. SGTC_2321 7390090 138.78 µM -0.910998361290409 0.163006803008711 no 2830 0.181148118550466 4010 649046 SGTC_547 1120-0019 610 nM -0.91103232596273 0.162997761901461 no 2831 0.181139170748393 3921 3676939 SGTC_2274 7947094 46.08 µM -0.911461479556444 0.162883552942848 no 2832 0.181026136496288 3935 2971028 SGTC_2720 fluspirilene 36.88 µM -0.914296670556485 0.162130342464144 no 2833 0.180280489797294 3979 3396 An atypical antipsychotic. SGTC_1792 st045773 43.6 µM -0.9145813652822 0.162054834605518 no 2834 0.180205722575633 3918 2919270 SGTC_303 1348-1668 34.2 µM -0.915201663222579 0.161890396066311 no 2835 0.180042885830653 3991 5380509 SGTC_137 0438-0332 85.389 µM -0.915514311999759 0.161807555327157 no 2836 0.179960846252908 3977 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.916640740463732 0.16150932116724 no 2837 0.179665464175431 3882 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2510 benzyl isothiocyanate 8.31 µM -0.917494976590612 0.161283391990636 no 2838 0.179441662029568 3974 2346 DNA damaging agent; causes G2/M arrest. SGTC_1785 bathophenanthroline 24 µM -0.921781099203782 0.160152907992072 no 2839 0.178321384114687 3922 72812 An iron chelator. SGTC_1936 st074407 74.3 µM -0.922186943385674 0.160046133900789 no 2840 0.178215536178962 4046 809813 SGTC_613 3914-0030 117 µM -0.922516536773804 0.159959454992467 no 2841 0.178129604303423 3722 1145395 SGTC_3037 9091026 49.47 µM -0.926651260771898 0.158874683596979 no 2842 0.177053815407644 3969 25236398 YIL048W NEO1 SGTC_195 4234-0266 16.654 µM -0.926730511370997 0.158853938895094 no 2843 0.177033235845797 3998 2303354 SGTC_1693 xanthone 101.9 µM -0.927925790755476 0.15854127690291 no 2844 0.176723032529921 4054 7020 An insecticide. SGTC_1827 berberine 7.24 µM -0.928642565838856 0.158353976099354 no 2845 0.176537177342887 3948 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1446 4239-0190 62 µM -0.933806524350607 0.157008872058631 no 2846 0.175201851710705 4032 1340085 SGTC_573 3702-0553 84.7 µM -0.936737460773708 0.156248777196463 no 2847 0.174446810885278 3958 1222756 SGTC_1137 ixabepilone 100 µM -0.938566421594028 0.155775693700938 no 2848 0.173976699763841 3982 154225 A novel microtubule stabilizer. SGTC_1929 genistein trimethyl ether 50.5 µM -0.940288426230198 0.155331139897473 no 2849 0.173534817317949 3996 136420 SGTC_3258 9138477 49.47 µM -0.941684468439758 0.154971351888917 no 2850 0.173177104589636 4048 4970355 SGTC_2680 butyl paraben 22.24 µM -0.941801929832111 0.154941104859741 no 2851 0.173147028483391 4081 7184 An antifungal and steroid mimetic. SGTC_956 1185-0240 191 µM -0.942084831785502 0.154868271875983 no 2852 0.173074604813131 4018 1416193 SGTC_2152 5568786 200 µM -0.942330166149867 0.154805128963965 no 2853 0.173011814173394 3995 5399883 SGTC_1481 3346-2004 36 µM -0.945691889202776 0.153941619149093 no 2854 0.172152880298172 4060 2770522 SGTC_864 0469-0573 172 µM -0.946336600288583 0.153776380232608 no 2855 0.171988465535345 3995 689425 SGTC_3102 9121669 49.47 µM -0.946904542520443 0.153630914413316 no 2856 0.171843711510526 4048 41905072 SGTC_850 0388-0143 75.9 µM -0.948234112769578 0.153290730876683 no 2857 0.171505142246468 3983 67273 SGTC_2801 7907800 81.82 µM -0.948777039934598 0.15315196127878 no 2858 0.171367010871073 4054 6620925 SGTC_777 1315-0167 517 µM -0.949480645446973 0.152972246960152 no 2859 0.171188105586006 4049 4221767 SGTC_2626 ethyl orsellinate 100 µM -0.949690809802201 0.152918594088467 no 2860 0.171134690414932 4027 75653 A natural product. SGTC_1994 st072947 40.9 µM -0.950435496907245 0.152728583313852 no 2861 0.170945507262977 4089 5286565 YDL195W SEC31 SGTC_2178 5812956 200 µM -0.950896019863774 0.152611156894903 no 2862 0.170828581236837 4000 5403383 SGTC_1638 st008370 60.6 µM -0.952405084584862 0.15222678793851 no 2863 0.170445790898821 3988 24207134 SGTC_2464 5717415 7.67 µM -0.953879022648698 0.151851986972623 no 2864 0.17007244153105 4034 5285744 SGTC_2202 7226349 200 µM -0.956262052157354 0.151247315329903 no 2865 0.169469928411502 3988 844334 SGTC_858 0438-0351 2.77 µM -0.960060294117196 0.150286861751304 no 2866 0.16851243523256 4013 2799119 SGTC_2173 5763948 167 µM -0.960475921884323 0.150182010079673 no 2867 0.168407871777168 4024 2867177 SGTC_1389 3405-0187 19 µM -0.960568143747592 0.150158751603202 no 2868 0.168384676297676 4015 799890 SGTC_2956 9076196 2.52 µM -0.962881335272485 0.14957614703304 no 2869 0.167803538631787 4072 16423868 SGTC_2290 7904846 200 µM -0.963127807721692 0.149514159085481 no 2870 0.16774169415569 4094 2962154 SGTC_2634 4'-methoxyflavone 100 µM -0.965770651813869 0.148850560065165 no 2871 0.167079478536286 4063 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_808 0711-0032 135 µM -0.96580533257503 0.148841865080602 no 2872 0.167070799822437 3963 4252555 SGTC_1892 st058411 7.36 µM -0.966137280858483 0.148758657862546 no 2873 0.166987745874829 4070 3934738 SGTC_3341 9147222 25.867 µM -0.966531931546378 0.148659773919322 no 2874 0.166889038346341 4063 1939759 SGTC_2210 7115885 190.385 µM -0.967432929900095 0.148434183868253 no 2875 0.166663827426556 4112 2927039 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.968174597939235 0.148248658484034 no 2876 0.166478589486884 4085 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2213 7173844 200 µM -0.968459094426449 0.14817753397585 no 2877 0.166407569338592 4002 892728 SGTC_1668 st014914 51.6 µM -0.970357254332076 0.147703575839098 no 2878 0.165934223832527 4067 2839556 SGTC_2367 9070478 135.38 µM -0.971793585660379 0.147345608804053 no 2879 0.165576623783913 4010 572802 SGTC_980 1473-0395 201 µM -0.973175944518503 0.147001642442529 no 2880 0.165232932168075 3938 768876 SGTC_1024 4507-0395 26 µM -0.975064260900785 0.146532651684692 no 2881 0.164764192572946 4142 4201836 SGTC_2467 5474540 200 µM -0.980811158575758 0.14511151115836 no 2882 0.163342937267385 4023 5413519 SGTC_1360 1598-0022 39.8 µM -0.981044934974997 0.145053898004609 no 2883 0.163285291510082 4114 761525 SGTC_949 1165-0505 146 µM -0.981296120089291 0.144992011711335 no 2884 0.163223367757008 4090 6244267 SGTC_401 neomycin 50 µM -0.981773852374529 0.14487435840816 no 2885 0.163105636269171 4042 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2425 5628681 7.85 µM -0.982366948860715 0.144728383301294 no 2886 0.1629595514473 4139 5714958 SGTC_1455 4262-0120 131 µM -0.986778306732594 0.143645752581948 no 2887 0.161875665847957 4159 1529587 SGTC_1411 3909-8223 150 µM -0.987072907139776 0.143573647265785 no 2888 0.161803449223425 4099 X1411 SGTC_2952 9073731 13.78 µM -0.988735875851174 0.143167083360284 no 2889 0.161396192569868 4148 16457353 SGTC_1443 4112-3303 14 µM -0.989492782313457 0.142982292054348 no 2890 0.161211049741879 4114 704433 SGTC_2735 sertaconazole 140 nM -0.990435296451892 0.142752411844707 no 2891 0.16098070018064 4200 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_181 1447-1644 8.07 µM -0.993502163515111 0.142006129604279 no 2892 0.160232648326844 4096 534600 SGTC_1080 nisoldipine 24.4 µM -0.996940054201044 0.141172708583022 no 2893 0.159396804050057 4074 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3301 9125354 19.7965 µM -0.998012918024262 0.140913302912495 no 2894 0.159136547306562 4054 41905162 SGTC_3333 9141820 12.094 µM -1.00052641980355 0.140306834963348 no 2895 0.158527909277387 4076 1939433 SGTC_1462 k081-0014 26.5 µM -1.00084021633707 0.140231245509332 no 2896 0.158452031586861 3671 3270634 SGTC_2561 acetosyringone 100 µM -1.0023571847285 0.139866217901999 no 2897 0.158085556467624 4079 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_294 k038-0071 157 µM -1.00586622949473 0.139024314223507 no 2898 0.157239961533313 4090 24152826 SGTC_1727 st034309 9.9045 µM -1.00613636698399 0.138959645102435 no 2899 0.157174988441656 4167 870305 SGTC_879 0831-1030 162 µM -1.0093178855587 0.138199551669565 no 2900 0.156411102571166 4131 1549252 SGTC_2773 thioridazine 9.09 µM -1.01456101775522 0.136953115301159 no 2901 0.155157564719955 4132 5452 An antipsychotic. SGTC_2424 5537928 59.2 µM -1.01713753729087 0.136343429677863 no 2902 0.154544002701699 4122 5382802 SGTC_1149 3909-7961 23.3 µM -1.01723368067832 0.136320715121484 no 2903 0.154521138581424 4144 735261 SGTC_2079 5212404 121 µM -1.0199435328919 0.135681558118836 no 2904 0.153877620913916 4075 758462 SGTC_1432 4049-0298 68.4 µM -1.02033563793789 0.135589244876466 no 2905 0.153784653517218 4132 741646 SGTC_854 0422-0053 192 µM -1.02065938672968 0.13551305717727 no 2906 0.153707921292359 4124 3596728 SGTC_1963 st076565 50.3 µM -1.0212612232954 0.135371505134204 no 2907 0.153565346400556 4116 4914280 SGTC_2972 9093619 59.92 µM -1.02156533824818 0.135300015811935 no 2908 0.15349333498283 4077 25236256 SGTC_975 1335-0046 28.5 µM -1.0235646673631 0.134830671168383 no 2909 0.1530204704996 4126 16486740 SGTC_1326 1431-2094 10.8 µM -1.02374882282079 0.134787496728421 no 2910 0.152976964224598 4094 616278 SGTC_236 1509-0011 5.31 µM -1.02544611086839 0.134390021581974 no 2911 0.152576370211462 4171 3107280 SGTC_3074 9116018 49.47 µM -1.0260608575601 0.13424625740764 no 2912 0.152431449516428 4171 17027303 SGTC_1148 3909-7663 27.7 µM -1.0267160025758 0.134093162019235 no 2913 0.152277105887672 4150 4084526 SGTC_614 0462-0418 107 µM -1.02723717335751 0.133971459647909 no 2914 0.152154398961844 3898 5188303 SGTC_2149 5554786 194.827 µM -1.03070153849998 0.133164399911497 no 2915 0.151340401536331 4147 745063 YPR165W RHO1 SGTC_1531 st059297 52.4 µM -1.03121199082559 0.13304576816726 no 2916 0.151220709415297 4123 7566702 SGTC_607 4491-0986 66.8 µM -1.03297500211246 0.13263659490801 no 2917 0.150807798624393 4149 698981 YDR232W HEM1 SGTC_1400 3771-8998 51.5 µM -1.03339640184839 0.132538921703576 no 2918 0.150709214819789 4019 670767 SGTC_1710 st031758 61.5 µM -1.03424842424629 0.132341588999761 no 2919 0.150510020686548 4157 5394341 SGTC_407 eburnamonine 100 µM -1.03630495044951 0.131866121673192 no 2920 0.150029948683494 3964 3195 SGTC_1995 st072814 61.1 µM -1.03772656771331 0.131538134468978 no 2921 0.149698686203667 4113 5769371 SGTC_871 0574-0004 149 µM -1.03903635273255 0.131236447332339 no 2922 0.149393914879309 4105 9551173 SGTC_203 k066-0004 30.888 µM -1.04022842085217 0.130962289995051 no 2923 0.149116895153745 4219 6795412 SGTC_1405 3909-7894 12 µM -1.04156899759835 0.130654451019965 no 2924 0.148805774242253 4125 7104060 SGTC_469 w7 172 µM -1.04249187415381 0.130442820234075 no 2925 0.148591845444684 4209 45115570 A P450 inhibitor. SGTC_1614 st002383 48.6 µM -1.04289816638104 0.130349725943609 no 2926 0.148497729480172 4140 1947235 SGTC_3263 9137018 49.47 µM -1.04311428554425 0.130300224996148 no 2927 0.148447682587949 4122 43844957 SGTC_1037 k284-1091 78.7 µM -1.04312134325188 0.13029860868498 no 2928 0.148446048419012 4108 3334711 SGTC_353 1988-1175 58.3 µM -1.04770054101948 0.129252832962699 no 2929 0.147388299115822 3984 2788357 SGTC_1947 st076332 61.6 µM -1.04810418130382 0.129160931290799 no 2930 0.147295305031264 4033 24208416 SGTC_1152 3909-8331 15.9 µM -1.04898291117343 0.128961016904738 no 2931 0.147092991784931 4098 16001939 SGTC_3227 9130768 49.47 µM -1.04904360130336 0.128947217596027 no 2932 0.147079025752288 4195 17720899 SGTC_191 3914-0123 66.505 µM -1.04941829024306 0.128862046052425 no 2933 0.14699282190005 4130 3144412 SGTC_1801 st050089 28.441 µM -1.05273264961777 0.128110349293463 no 2934 0.146231770174173 4181 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1006 4099-6547 255 µM -1.05300852793339 0.128047917679845 no 2935 0.146168541802971 4183 3146833 SGTC_1864 st057645 30.4 µM -1.05503400260921 0.127590197389597 no 2936 0.145704886946407 4179 688666 SGTC_1534 6-azauridine 81.6 µM -1.055986631215 0.127375314509437 no 2937 0.145487161342207 4169 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_893 0958-0369 48.9 µM -1.05657798456838 0.127242050589183 no 2938 0.14535211620923 4071 6819948 SGTC_2731 amoxapine 43.43 µM -1.06598755980267 0.125134607960136 no 2939 0.143214632748147 4283 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1315 1237-0019 3.69 µM -1.06673116527736 0.124969109634979 no 2940 0.143046624858052 4171 825140 SGTC_1613 st002381 52.1 µM -1.06693401057717 0.124923990534266 no 2941 0.143000817753498 4148 551167 SGTC_1802 st050112 57.9 µM -1.06716612137868 0.124872375839418 no 2942 0.142948413990809 4152 4662563 SGTC_2872 9044037 25.97 µM -1.06904680582023 0.124454715725793 no 2943 0.142524289580392 4168 6465195 SGTC_338 4055-0136 114 µM -1.07137988322035 0.123937947498071 no 2944 0.141999327177726 4125 2900563 SGTC_2892 9047358 58.44 µM -1.07142628541872 0.123927684832187 no 2945 0.141988899578958 4174 6466771 SGTC_3251 9135047 49.47 µM -1.07355465024771 0.123457598509028 no 2946 0.141511166162232 4193 17682963 SGTC_992 3909-8734 162 µM -1.07671209553157 0.122762525205865 no 2947 0.140804453495058 4192 4288319 SGTC_2239 6685329 187.64 µM -1.07718433085731 0.122658804732429 no 2948 0.140698962016872 4227 805680 SGTC_1036 k216-0215 33.5 µM -1.08081651234255 0.121863096877344 no 2949 0.13988937091391 4150 622330 SGTC_1713 st033146 12.748 µM -1.08814156164562 0.12026943381693 no 2950 0.138266309130341 4182 674619 SGTC_3276 9139060 49.47 µM -1.08828178966632 0.120239069230752 no 2951 0.138235363588082 4260 4870619 SGTC_2656 pseudo-anisatin 100 µM -1.08843591955278 0.120205700604547 no 2952 0.138201355627422 4206 6708809 A neurotoxin. SGTC_1291 0993-0025 5.79 µM -1.0927862612229 0.119266555588544 no 2953 0.137243827585919 4185 4353356 SGTC_430 0958-0115 16.4 µM -1.09337892776383 0.119139013563221 no 2954 0.137113730809734 4137 6833180 SGTC_3259 9138485 49.47 µM -1.09405577105406 0.118993474479212 no 2955 0.136965259398956 4199 17646153 SGTC_1482 3346-2049 8.48 µM -1.09908205066087 0.117916619406318 no 2956 0.13586613917715 4197 3826804 SGTC_1949 st076024 69.1 µM -1.09939537521811 0.117849720229716 no 2957 0.135797823575345 4116 2921930 SGTC_2725 haloperidol 53.21 µM -1.102048579137 0.117284300494787 no 2958 0.135220276296005 4127 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_612 0302-0167 22.4 µM -1.10539122851696 0.116574693039604 no 2959 0.13449505143898 4203 235821 SGTC_295 k015-0027 31 µM -1.10949642123937 0.11570737890408 no 2960 0.133608043722179 4231 3887424 SGTC_1879 gemcitabine 100 µM -1.11397792364319 0.114765804725352 no 2961 0.132644328805639 4183 60750 A nucleoside analog which inhibits DNA replication. SGTC_1183 1254-0324 198 µM -1.11611432603557 0.114318865503091 no 2962 0.132186600334242 4287 5799357 SGTC_1334 1486-0610 236 µM -1.11721646497612 0.114088781261131 no 2963 0.131950891158566 4286 3742339 SGTC_2258 7960471 200 µM -1.11788134276207 0.113950139961715 no 2964 0.131808837205252 4239 2974708 SGTC_1126 isoteolin 1.0172 µM -1.11882610183026 0.113753343942303 no 2965 0.131607166964345 4152 133323 SGTC_2593 nobiletin 86.24 µM -1.12193912562113 0.113106606700232 no 2966 0.130944161798262 4215 72344 An anti-infammatory. SGTC_2841 9004761 38.96 µM -1.1258823965458 0.112291156359416 no 2967 0.130107650706831 4198 2991039 SGTC_3021 9087658 49.47 µM -1.12644628291387 0.112174891458819 no 2968 0.129988332829896 4218 25237042 SGTC_2296 7971656 126.45 µM -1.12668751742513 0.112125178812722 no 2969 0.129937310952295 4259 666570 SGTC_523 1934-0222 13.7 µM -1.12910184835975 0.11162851048331 no 2970 0.129427435845526 4166 1361595 SGTC_2690 usnic acid 100 µM -1.13119715533326 0.111198748172446 no 2971 0.128986059493435 4252 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_300 r073-0011 5.04 µM -1.13160340788769 0.111115560188796 no 2972 0.128900603359444 4214 2735780 SGTC_965 1291-5240 308 µM -1.13239590552072 0.110953409417302 no 2973 0.128734012746745 4243 2834598 SGTC_86 0417-1630 471.922 µM -1.13242731300279 0.110946986711962 no 2974 0.128727413671086 4238 3634867 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.13316494722334 0.110796220012993 no 2975 0.128572495662107 4271 23665772 A membrane-active detergent. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.13476889271317 0.110468892799101 no 2976 0.128236081571528 4273 91467 include heat shock SGTC_3156 9099931 49.47 µM -1.1347741749979 0.110467815956712 no 2977 0.128234974667484 4256 18111053 SGTC_166 k072-0058 166.424 µM -1.13734147666075 0.109945338189165 no 2978 0.127697781070961 4125 5846229 SGTC_2053 5265679 138 µM -1.1397492038509 0.109456949357374 no 2979 0.12719540082284 4146 764595 SGTC_1182 1222-0449 220 µM -1.14134765324587 0.109133578018342 no 2980 0.126862639511546 4232 658318 SGTC_947 3447-0010 211 µM -1.14195532542324 0.109010824307852 no 2981 0.126736294927968 4191 748350 SGTC_786 4544-0069 423 µM -1.1439914541913 0.108600236576489 no 2982 0.126313590553625 4227 748821 YLR208W SEC13 SGTC_265 mycophenolic acid 32.932 µM -1.14618861456705 0.10815842572614 no 2983 0.125858558891638 4303 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_789 1309-1135 70.6 µM -1.14987065872786 0.107420934079042 no 2984 0.125098573677106 4211 3092424 SGTC_2259 7964009 200 µM -1.15063181605974 0.107268931930094 no 2985 0.124941869062104 4267 313134 SGTC_1048 3161-0300 24.5 µM -1.15450813551187 0.106497241428896 no 2986 0.124145952558421 4247 2165101 SGTC_1662 st014054 52 µM -1.15463697020283 0.106471662255401 no 2987 0.12411956024804 4285 2838777 SGTC_2166 5933061 31.504 µM -1.15550560892905 0.106299316239603 no 2988 0.123941718528424 4386 2877375 SGTC_1573 oleylamine 1.06 µM -1.15871522066953 0.105664247135397 no 2989 0.123286142283618 4245 5356789 An amine of the fatty acid oleic acid. SGTC_2183 6420625 130.508 µM -1.16209491604723 0.104998494436924 no 2990 0.122598456151955 4254 2897619 SGTC_1429 4049-0205 9.46 µM -1.16252772768509 0.104913456410485 no 2991 0.12251058423352 4270 22774478 SGTC_1260 0700-1617 7.75 µM -1.16390782636435 0.104642630194006 no 2992 0.122230683790659 4241 2853078 SGTC_174 3553-0389 74.3 µM -1.164046777365 0.104615390971621 no 2993 0.122202527768997 4330 738071 SGTC_200 k038-0079 37.545 µM -1.16481575382878 0.104464737735323 no 2994 0.122046790291647 4221 3436683 SGTC_1233 0325-0408 14.2 µM -1.16704116172075 0.10402963506703 no 2995 0.121596873590682 4278 12874 SGTC_1625 st003711 30.1 µM -1.17089573710677 0.103279116076742 no 2996 0.120820344419467 4322 24207034 YER133W GLC7 SGTC_3146 9095609 49.47 µM -1.17427327903106 0.10262471788037 no 2997 0.120142791328108 4310 17173999 SGTC_1681 tripelennamine 100 µM -1.17723583372568 0.102053209120494 no 2998 0.119550694924354 4202 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_935 2996-0153 430 µM -1.17905203839954 0.101703990636508 no 2999 0.11918872750291 4265 23738523 SGTC_1250 0485-0349 40.2 µM -1.1854290237728 0.100484719925746 no 3000 0.117923930954895 4285 6842794 YDL195W SEC31 SGTC_1372 2752-0194 270 µM -1.18598465679323 0.100378990944942 no 3001 0.117814179406789 4211 823334 SGTC_900 1112-0045 141 µM -1.18922122523506 0.099764731891954 no 3002 0.117176312151555 4145 56211 YIL048W NEO1 SGTC_1964 st076914 61 µM -1.18978112789926 0.0996587487741878 no 3003 0.117066214479192 4322 24208661 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.19214527085489 0.0992121507660357 no 3004 0.116602144321965 4340 165506 SGTC_1602 st001878 87.6 µM -1.19483750186718 0.0987053595712929 no 3005 0.116075262513109 4264 595405 YLR310C CDC25 SGTC_2095 5432005 200 µM -1.19555765532507 0.0985701181306373 no 3006 0.115934612141731 4280 783734 SGTC_2224 6650123 117.647 µM -1.19557260653468 0.0985673118017175 no 3007 0.115931693361842 4285 2908370 SGTC_2090 5301565 104.445 µM -1.19767221792023 0.098173797210861 no 3008 0.115522324546181 4275 2056344 SGTC_595 3909-8003 73.7 µM -1.20135957925788 0.097485490031394 no 3009 0.114805874219944 4358 699517 SGTC_2133 5320837 200 µM -1.20305136815497 0.0971708767368143 no 3010 0.114478221493563 4313 2841355 SGTC_1960 st011366 51.8 µM -1.20369422655711 0.0970515232283782 no 3011 0.114353892289966 4302 3972846 SGTC_606 k015-0008 38.6 µM -1.20412881015001 0.0969708991379781 no 3012 0.114269898042559 4369 1970475 SGTC_464 bw-b 70c 158 µM -1.20539507367399 0.096736261882002 no 3013 0.114025411182724 4304 5353454 SGTC_254 nsc-64875 3.808 µM -1.20630456639624 0.0965679913407834 no 3014 0.1138500388053 4288 56993 SGTC_2147 5545932 89.7195 µM -1.20643386512479 0.09654408649895 no 3015 0.113825122471182 4328 797404 SGTC_272 doxorubicin 8.13 µM -1.20672573008644 0.0964901422778946 no 3016 0.113768893321523 4300 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_543 3844-1095 191 µM -1.20834433630985 0.0961913837437495 no 3017 0.113457420591418 4287 4230703 SGTC_74 000s-0487 160.283 µM -1.20894901435877 0.0960799483353902 no 3018 0.113341216942408 4176 677548 SGTC_3222 9128301 49.47 µM -1.20962801266112 0.0959549297013322 no 3019 0.113210832055014 4281 4911358 SGTC_2416 tofa 880 nM -1.21003563116284 0.0958799355909913 no 3020 0.113132610390928 4278 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1190 1486-1332 13 µM -1.21140316793101 0.0956286495728734 no 3021 0.112870462925137 4285 4150046 SGTC_1722 st034304 3.6505 µM -1.21400649511394 0.0951516259854321 no 3022 0.112372621955894 4255 4036148 YLR033W RSC58 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.21516750162033 0.0949394535773748 no 3023 0.112151106294958 4425 16725076 SGTC_2058 5236698 133 µM -1.21634931564758 0.0947238368031039 no 3024 0.111925941380072 4260 766665 SGTC_1511 0906-3109 28.5 µM -1.21659604591699 0.0946788675230554 no 3025 0.111878973954443 4303 2882180 SGTC_2254 7938975 95.19 µM -1.21737863822802 0.0945363356560544 no 3026 0.111730093410109 4375 2969277 SGTC_2889 9059656 51.95 µM -1.22240547707031 0.0936245779202034 no 3027 0.110777164533959 4374 3949838 SGTC_229 benomyl 22.8748 µM -1.22545249957215 0.0930750852396631 no 3028 0.110202388338872 4325 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2639 lactacystin 53 µM -1.22646471092966 0.0928930739599591 no 3029 0.110011923631034 4339 3870 A proteasome inhibitor. SGTC_680 0417-1641 114 µM -1.23188129932792 0.09192355761415 no 3030 0.108996714000719 4315 2835990 SGTC_386 1509-0011 3.07 µM -1.23217365407663 0.0918714429324263 no 3031 0.108942111287473 4311 3107280 SGTC_1771 st048882 4.1505 µM -1.23312336366389 0.0917023002550662 no 3032 0.108764870967197 4356 4580403 SGTC_1645 Cervolide 78 µM -1.23557472327108 0.0912667811397241 no 3033 0.108308342568071 4323 23173 A fragrance. SGTC_224 benfluorex 43.875 µM -1.23655754517166 0.0910926001148362 no 3034 0.108125694775387 4337 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1391 3442-0225 151 µM -1.23792949804011 0.0908498676510764 no 3035 0.107871101773818 4279 5227075 SGTC_1242 0402-0103 60.1 µM -1.2430034968968 0.0899563206658791 no 3036 0.106933272432186 4246 432868 SGTC_984 1492-0255 2.91 µM -1.24501776653895 0.0896034182283285 no 3037 0.10656260980743 4299 1585198 SGTC_997 3996-0078 137 µM -1.24541328730889 0.0895342436010904 no 3038 0.10648993579063 4365 735687 SGTC_3159 9100096 49.47 µM -1.24622298015352 0.0893927562094098 no 3039 0.106341272338258 4256 25236875 SGTC_1160 4092-0570 10.5 µM -1.24687724549175 0.0892785500849011 no 3040 0.106221255641841 4312 4994975 SGTC_36 0335-0881 14.2 µM -1.24773293664052 0.089129347697201 no 3041 0.106064437626955 4226 23828853 SGTC_951 1171-0579 82.7 µM -1.24879230088348 0.0889448890686882 no 3042 0.105870525336344 4287 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_815 1582-0027 36.9 µM -1.25095836087014 0.0885686151986598 no 3043 0.105474834762285 4356 3128206 SGTC_993 3909-8757 62.7 µM -1.25127187074133 0.0885142526789951 no 3044 0.105417652268478 4264 4288324 YLR208W SEC13 SGTC_2484 5809818 12.04 µM -1.25727782457213 0.087477616341873 no 3045 0.104326525479189 4289 2870548 SGTC_177 1327-0068 8.361 µM -1.25759202527888 0.0874236353168126 no 3046 0.10426966945681 4321 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3022 9087993 49.47 µM -1.25841272489569 0.0872827529073367 no 3047 0.104121266142663 4403 17173644 SGTC_3115 9123671 49.47 µM -1.25943150711443 0.0871081032560119 no 3048 0.103937257572256 4475 3286988 SGTC_2344 7990960 76.95 µM -1.26131205119526 0.0867864076405243 no 3049 0.103598220499242 4313 140813 SGTC_3000 9075062 71.4286 µM -1.26283240488669 0.0865269776952219 no 3050 0.103324708184318 4307 17057871 SGTC_1945 st075991 56.6 µM -1.26542738591465 0.0860855155397217 no 3051 0.10285908163201 4313 1084980 SGTC_2990 9074105 71.4286 µM -1.26636261830755 0.0859268261455165 no 3052 0.10269164391263 4248 6502001 SGTC_3328 9140624 29.0385 µM -1.26910193677669 0.0854632807510372 no 3053 0.102202354809649 4352 4904392 SGTC_2940 9060638 45.86 µM -1.2709090100881 0.0851585160548256 no 3054 0.101880510325797 4333 4027022 SGTC_1637 st007924 17.4 µM -1.27174958044026 0.0850170308608786 no 3055 0.101731054174338 4250 683336 SGTC_2023 5144124 124 µM -1.2773706131804 0.0840754214470376 no 3056 0.100735717290718 4327 2830192 SGTC_2945 9067681 61.76 µM -1.27948692722946 0.0837229424369465 no 3057 0.100362820111286 4415 16456930 SGTC_2029 5175081 200 µM -1.28070107402641 0.0835212240857617 no 3058 0.100149341197107 4304 1380876 SGTC_1000 4048-0884 8.67 µM -1.28294808310779 0.0831488697607271 no 3059 0.0997551327627164 4387 13040088 SGTC_2961 9083290 32.55 µM -1.28368255411951 0.083027430862572 no 3060 0.0996265255488013 4296 17741490 SGTC_2326 6164455 177.58 µM -1.28651031320642 0.0825611288544061 no 3061 0.0991325109362429 4309 2888790 SGTC_555 4296-0685 37 µM -1.29369636032252 0.0813850113053268 no 3062 0.097885161521391 4341 2908540 YHR072W ERG7 SGTC_3023 9089636 49.47 µM -1.29528295895263 0.0811270491880516 no 3063 0.0976113178022234 4425 17249241 SGTC_222 nsc-310342 10.666 µM -1.29674968495285 0.0808891262281611 no 3064 0.0973586639549119 4392 432556 SGTC_2314 7727897 200 µM -1.30187200563275 0.0800623473192037 no 3065 0.0964800718408126 4343 900724 SGTC_1740 st038286 13.222 µM -1.30515770477487 0.0795353855030349 no 3066 0.0959195764442736 4399 716786 SGTC_2712 st079126 47.7 µM -1.30607209843559 0.0793892025247448 no 3067 0.0957640201736011 4359 3152970 SGTC_1336 1486-0901 104 µM -1.31480462562481 0.0780033733534177 no 3068 0.0942877862378597 4378 5006114 SGTC_2377 9073351 62.6 µM -1.31524437993605 0.0779340740158188 no 3069 0.094213892141446 4366 7337946 YHR072W ERG7 SGTC_834 0312-0008 75.7 µM -1.31563532400709 0.07787250574883 no 3070 0.0941482357482977 4396 6385573 YIL048W NEO1 SGTC_655 k060-0012 42 µM -1.31674240598826 0.0776983559653649 no 3071 0.0939624920184696 4364 5994525 SGTC_1992 st073643 23.3 µM -1.32030823737832 0.0771394415697951 no 3072 0.0933660632248604 4359 3161292 SGTC_2418 pentamidine 31.67 µM -1.32067420340771 0.077082252744569 no 3073 0.0933050095463637 4329 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2939 9044578 71.43 µM -1.32391829336434 0.0765767127926884 no 3074 0.0927650910174672 4313 2653634 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.32531028925491 0.0763605671125881 no 3075 0.0925341288531989 4375 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2295 7971645 200 µM -1.32828904031107 0.0758995939909604 no 3076 0.0920413194684996 4436 2978226 YKL099C UTP11 SGTC_61 0978-8327 98.565 µM -1.328542506873 0.0758604671144899 no 3077 0.0919994754381073 4301 6150059 YHR072W ERG7 SGTC_3280 9140961 49.47 µM -1.32908629660758 0.0757765757479998 no 3078 0.0919097503630178 4414 4901226 SGTC_1986 st071812 45 µM -1.3293624383249 0.0757340019573683 no 3079 0.0918642119158347 4325 11838594 SGTC_932 2857-0803 154 µM -1.3294911598994 0.0757141627029684 no 3080 0.0918429901913942 4405 674898 SGTC_3161 9100388 49.47 µM -1.33233822781458 0.0752763689133229 no 3081 0.0913745353495917 4466 25236368 SGTC_1441 4106-0040 13 µM -1.33545055495051 0.0747999969366123 no 3082 0.0908644639790274 4411 2904180 SGTC_1294 1000-1494 117 µM -1.33962645412649 0.074164452666735 no 3083 0.0901834094328592 4390 712797 YDL207W GLE1 SGTC_403 arphamenine a 50 µM -1.3408219312541 0.0739832704980674 no 3084 0.0899891369497872 4395 5487158 An arginine aminopeptidase inhibitor. SGTC_2117 5521686 200 µM -1.34246387323346 0.0737349752163264 no 3085 0.0897228182603818 4380 803312 SGTC_1900 st060200 72.8 µM -1.34474304306702 0.0733913744160633 no 3086 0.0893541146629463 4388 688945 SGTC_1068 loratadine 26.9 µM -1.34542719253704 0.0732884734400775 no 3087 0.0892436593631181 4445 3957 A H1 histamine antagonist. SGTC_1005 4092-0690 4.4 µM -1.35265641372716 0.0722078816796136 no 3088 0.0880827104838983 4414 1529343 SGTC_917 harmaline 728.087 nM -1.35450137429523 0.0719340707943749 no 3089 0.0877882376194976 4343 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2000 st075254 36.4 µM -1.35483032573733 0.0718853348001336 no 3090 0.0877358111380171 4297 17234175 SGTC_3282 9108498 15.4605 µM -1.35734985372171 0.0715128919617812 no 3091 0.0873350368571769 4364 16459645 SGTC_1070 indatraline 8.81 µM -1.36002541116169 0.0711190074808576 no 3092 0.0869109413408285 4463 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1868 st057644 42.7 µM -1.36495352932416 0.0703978732658685 no 3093 0.0861338281334265 4430 688665 SGTC_3126 9127922 49.47 µM -1.36671595881206 0.0701413452685772 no 3094 0.0858571768435608 4412 45595682 SGTC_1485 3909-9022 254 µM -1.36908667908801 0.0697974132252437 no 3095 0.0854860908725808 4475 714516 SGTC_2893 9048488 25.97 µM -1.36949735852342 0.0697379660668973 no 3096 0.0854219299653095 4443 6467338 SGTC_1114 scopoletin 1.73284 µM -1.37535883061417 0.0688937411860018 no 3097 0.0845101129258652 4441 5280460 A coumarin with genotoxic properties. SGTC_2072 5231554 129 µM -1.37697530294903 0.0686623130189615 no 3098 0.0842599418095302 4479 789545 SGTC_260 nsc-65238 3.989 µM -1.37743539323936 0.0685965522416358 no 3099 0.0841888382824541 4406 3246252 SGTC_819 1013-0258 27.7 µM -1.37823785126591 0.0684819730529298 no 3100 0.0840649321648971 4419 5753198 SGTC_727 3032-0951 202 µM -1.3823900476658 0.0678914576167614 no 3101 0.0834259851425828 4461 3652836 SGTC_1385 3091-4834 14.1 µM -1.38276845375271 0.0678378377237961 no 3102 0.0833679373487424 4412 4072814 SGTC_178 4092-0806 87.505 µM -1.38634957936502 0.0673320127335272 no 3103 0.0828200922565778 4313 2169044 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.38729934117145 0.0671983516304398 no 3104 0.0826752519672043 4448 66535 A nucleotide analog. SGTC_1933 st074711 15.9 µM -1.38999956664711 0.0668194663680538 no 3105 0.0822645044740042 4418 17250958 SGTC_2388 9080168 200 µM -1.3929571799505 0.0664063643968634 no 3106 0.0818163698523709 4444 15943073 SGTC_3140 9094243 49.47 µM -1.39370043147894 0.0663028629594369 no 3107 0.0817040429460442 4383 19291112 SGTC_2664 lyso-paf C-16 73.48 µM -1.39383216035308 0.0662845321042969 no 3108 0.0816841470187899 4384 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_17 0960-0276 49.807 µM -1.39535105717051 0.0660734520235378 no 3109 0.0814550012714584 4423 6821114 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.39711905529725 0.0658284107797764 no 3110 0.0811888862550103 4461 16486 A toxic proline analog. SGTC_2155 5570423 76 µM -1.40145321290942 0.06523068452865 no 3111 0.0805392946132856 4403 797402 SGTC_2197 6588183 93.1375 µM -1.40283057332264 0.0650416162829521 no 3112 0.0803336838667381 4436 884136 SGTC_2862 9027634 71.43 µM -1.4032258584213 0.0649874346984635 no 3113 0.0802747494845233 4396 5012562 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.40445086005715 0.0648197466749975 no 3114 0.0800923174087092 4442 6708561 SGTC_631 k072-0230 41.5 µM -1.40698500607715 0.0644739190310393 no 3115 0.0797159174651284 4442 5773147 SGTC_2390 9097792 176.6 µM -1.41010797317947 0.0640497104125774 no 3116 0.0792539016681127 4480 4497149 SGTC_1844 rapamycin 4 nM -1.41121165105113 0.0639003122577889 no 3117 0.0790911078687116 4290 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2083 5306046 65.942 µM -1.41445771466722 0.0634624828482379 no 3118 0.0786137772700562 4428 539837 SGTC_768 0384-0033 77.3 µM -1.4150237648878 0.0633863735738061 no 3119 0.0785307641554191 4403 3965305 YMR134W ERG29 SGTC_1111 tnp00062 510.699 nM -1.42172347026971 0.0624909410978631 no 3120 0.0775532719370108 4471 676306 SGTC_2887 9044784 58.44 µM -1.42543241434126 0.0619994897303599 no 3121 0.0770161218889686 4382 6465546 SGTC_138 0850-0259 40.9225 µM -1.42850132545762 0.0615951301245101 no 3122 0.0765738066925571 4388 6813004 SGTC_408 cantharidin 100 µM -1.43229669812628 0.0610979036969671 no 3123 0.0760294638285287 4430 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1672 st016598 6.51 µM -1.43752752458468 0.0604177684664024 no 3124 0.0752840788328318 4415 4665860 YNL267W PIK1 SGTC_2470 5664817 21.68 µM -1.43842373108794 0.0603018365136834 no 3125 0.0751569316407367 4506 2859561 SGTC_223 busulfan 5 mM -1.43985874196444 0.0601165683040578 no 3126 0.0749536839235174 4455 2478 A DNA alkylator. SGTC_1187 1391-0724 117 µM -1.44798547120182 0.0590757561017083 no 3127 0.0738105569551168 4508 6997986 SGTC_1305 1181-0477 144 µM -1.45480650613525 0.0582131241812493 no 3128 0.0728614182538757 4522 6252086 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.45522511244533 0.0581605085345521 no 3129 0.0728034754226201 4519 165521 SGTC_3241 9133421 49.47 µM -1.45913007786818 0.0576714821827132 no 3130 0.072264654585882 4563 17018221 SGTC_638 3970-0837 4.09 µM -1.46310442617743 0.0571770929400397 no 3131 0.0717194034611258 4457 4118451 YLR208W SEC13 SGTC_1049 3226-0134 66 µM -1.46314334970324 0.0571722675932794 no 3132 0.071714079090269 4501 5702385 SGTC_2582 agaric acid 100 µM -1.46370992065756 0.0571020661143816 no 3133 0.0716366118572842 4070 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2293 7624732 200 µM -1.4655834279317 0.0568704106125905 no 3134 0.0713809043619446 4373 894453 SGTC_483 fpl-64176 144 µM -1.47117167522528 0.0561838290874412 no 3135 0.0706223476019059 4611 3423 SGTC_776 4476-4378 112 µM -1.47181298911825 0.0561054560250065 no 3136 0.0705356925190014 4536 2892008 SGTC_731 3966-0296 387 µM -1.47365797323868 0.0558804667356324 no 3137 0.0702868518810224 4476 660956 SGTC_2404 5161160 200 µM -1.47389955606982 0.0558510593405282 no 3138 0.0702543186536931 4424 2831543 SGTC_1463 k081-0032 34.1 µM -1.47749791780823 0.0554144817997896 no 3139 0.0697711080122323 4004 977755 SGTC_2869 9037858 32.47 µM -1.47807710193941 0.0553444637118017 no 3140 0.0696935711113042 4449 27187042 SGTC_305 1682-2595 20.8 µM -1.48038010141533 0.055066743010399 no 3141 0.0693859186499657 4497 226033 SGTC_2733 amorolfine 100 µM -1.48089560319484 0.0550047292729463 no 3142 0.0693171974313469 4640 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1901 st060216 58.6 µM -1.48618073483918 0.0543721179957036 no 3143 0.068615660936619 4446 688792 SGTC_1883 5-benzylidenerhodanine 20 µM -1.48744343201686 0.0542218327634839 no 3144 0.0684488665575391 4470 1273210 SGTC_476 mead acid 10 µM -1.49299822972862 0.053564604923033 no 3145 0.0677188251466552 4562 5312531 An omega 9 fatty acid. SGTC_1194 1488-0194 225 µM -1.50335248061041 0.0523563795489986 no 3146 0.0663740867716883 4474 1391452 SGTC_2706 st078239 82.5 µM -1.50912460632776 0.0516922902627306 no 3147 0.065633471230091 4490 15434492 SGTC_2868 9035608 32.47 µM -1.51212551245299 0.0513496879619908 no 3148 0.0652509678551548 4488 6462614 SGTC_366 0181-0206 4.31 µM -1.51666494684417 0.0508348729308118 no 3149 0.0646756493431546 4485 274874 SGTC_69 0096-0274 206.684 µM -1.51730660971414 0.0507624349150884 no 3150 0.0645946450946087 4560 6741392 SGTC_1600 coumarin 106 71.1 µM -1.52249259349471 0.0501799960876083 no 3151 0.0639428499129862 4561 100336 A hepatotoxic, DNA x-linker. SGTC_1839 st053978 48 µM -1.5239904108862 0.0500127711125997 no 3152 0.0637555533032983 4544 3788398 SGTC_1840 st055363 71 µM -1.52442155148856 0.0499647185420823 no 3153 0.0637017199189856 4524 676033 SGTC_3279 9140807 49.47 µM -1.52673506688868 0.049707495335677 no 3154 0.0634134519085926 4560 45595718 SGTC_1351 1496-0003 46.5 µM -1.52769360696306 0.0496012321641437 no 3155 0.0632943140767731 4530 3891978 SGTC_640 3381-0960 37.1 µM -1.52988513474913 0.0493589617338859 no 3156 0.0630225817570776 4556 1745025 SGTC_880 0833-0487 87.2 µM -1.53181976757259 0.0491458766560164 no 3157 0.0627834583192569 4496 76075 SGTC_2575 plumbagin 510 nM -1.53186651431449 0.0491407369635298 no 3158 0.0627776891140574 4435 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3066 9117245 49.47 µM -1.53324659561889 0.0489891936540524 no 3159 0.0626075537346835 4553 17176980 SGTC_1171 0368-0077 21.4 µM -1.53903823458453 0.0483572949949448 no 3160 0.0618974811432262 4499 3239779 SGTC_2553 4-methylesculetin 85.09 µM -1.54084634110538 0.0481613617813351 no 3161 0.0616770939465522 4523 5319502 SGTC_1984 st072354 53.1 µM -1.5441031655222 0.047810043010083 no 3162 0.0612816710610663 4404 5762938 SGTC_1951 sophoraflavanone G 9.2 µM -1.55046854471686 0.0471293253481461 no 3163 0.060514548834128 4462 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_479 n-linoleoylglycine 10 µM -1.55048261143156 0.0471278296946965 no 3164 0.0605128619458863 4553 6433346 An anti-infammatory. SGTC_3209 9113616 49.47 µM -1.55348717140488 0.0468092387747655 no 3165 0.0601533958549765 4553 16649353 SGTC_441 propafenone 146 µM -1.55957899192881 0.0461685908542223 no 3166 0.0594297021074238 4509 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1909 st060837 51.5 µM -1.56660140407522 0.04543883509106 no 3167 0.0586039447308808 4468 678937 SGTC_77 0828-0286 12.516 µM -1.57117703696469 0.0449683557218939 no 3168 0.0580707661838255 4428 745345 SGTC_3121 9125696 49.47 µM -1.57127013191076 0.0449588242958289 no 3169 0.0580599579353641 4629 1235365 SGTC_948 3448-0295 75.3 µM -1.57303865051116 0.0447780651091565 no 3170 0.0578549344634183 4511 678569 SGTC_1518 st038567 90.8 µM -1.57502171670101 0.0445760736288109 no 3171 0.0576257159613677 4482 77966 SGTC_2040 5100729 123 µM -1.57971758293059 0.0441006875745824 no 3172 0.0570857785634591 4566 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.58268535071687 0.0438023594136067 no 3173 0.0567465994452611 4615 688801 SGTC_3335 9143315 29.6265 µM -1.59055051127322 0.0430196011727894 no 3174 0.0558553847327885 4556 4899691 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.59734115357885 0.0423529075242519 no 3175 0.0550948410265006 4515 364106 SGTC_1393 3470-5649 58.2 µM -1.60276438502715 0.0418264881713528 no 3176 0.0544933413055992 4542 4108395 SGTC_2240 6690706 185.951 µM -1.60334544056511 0.0417704022079011 no 3177 0.0544292046978439 4445 805876 SGTC_2135 5326629 150.42 µM -1.60342399326102 0.0417628246417313 no 3178 0.054420538675714 4500 5020077 SGTC_3247 9135149 49.47 µM -1.60359067971772 0.0417467489619387 no 3179 0.0544021532527124 4587 8934436 YOR116C RPO31 SGTC_1617 st002906 78 µM -1.60758232641766 0.0413632787791584 no 3180 0.0539633427617473 4525 5150859 SGTC_526 4469-0568 170 µM -1.60982364654954 0.041149213924036 no 3181 0.0537181807006703 4517 2901964 SGTC_708 3448-5400 146 µM -1.60987684870664 0.0411441436069518 no 3182 0.0537123720314217 4509 3462195 SGTC_3130 9127414 49.47 µM -1.61105260298551 0.0410322201196565 no 3183 0.0535841288390046 4588 1494646 SGTC_2937 9044753 11.33 µM -1.61320665426915 0.040827810323121 no 3184 0.0533498091272995 4488 6465530 YGL099W LSG1 SGTC_2338 7999974 200 µM -1.6164434804249 0.0405222043065389 no 3185 0.0529992320052445 4534 315925 SGTC_1030 k029-0042 36.7 µM -1.61969207284163 0.0402173571767475 no 3186 0.0526492199517651 4532 6080581 SGTC_3112 9123419 49.47 µM -1.62364550407639 0.0398488839277497 no 3187 0.0522257439498944 4598 17015854 SGTC_140 0062-0056 502.533 µM -1.6244054142358 0.0397783731186676 no 3188 0.0521446561614938 4468 3758964 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.62827405042271 0.0394209798101681 no 3189 0.0517333946276309 4623 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2200 6600604 21.907 µM -1.63276097047875 0.0390097446262598 no 3190 0.0512596393145963 4588 2904777 SGTC_3077 9117319 49.47 µM -1.63677318242548 0.0386449818733054 no 3191 0.0508389355801313 4521 17154678 SGTC_2603 homopterocarpin 100 µM -1.63745799881796 0.0385830015980436 no 3192 0.0507674040357009 4550 101795 A weak amylase inhibitor. SGTC_3212 9128307 49.47 µM -1.63856418078971 0.038483056156372 no 3193 0.0506520286440484 4462 27243542 SGTC_3285 9112818 20.8695 µM -1.63967203448631 0.0383831712650785 no 3194 0.0505366882985729 4552 17017947 YPR165W RHO1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.64153718907518 0.038215485082073 no 3195 0.0503429769447863 4594 688664 SGTC_2732 terfenadine 20 µM -1.64198358625847 0.0381754405977889 no 3196 0.0502967028638738 4641 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_316 k060-0003 58.6 µM -1.6429175467829 0.0380917694750251 no 3197 0.0501999970262494 4607 6152314 SGTC_413 propylparaben 100 µM -1.64484293818676 0.0379197506383708 no 3198 0.0500011024022842 4548 7175 A pharmaceutical preservative. SGTC_2924 9010168 62.78 µM -1.65141373410573 0.0373374677321251 no 3199 0.0493270611617426 4561 2993929 SGTC_2580 diallyl disulphide 81.36 µM -1.65160223404482 0.0373208718521415 no 3200 0.049307832156239 4540 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_755 1995-0008 37.3 µM -1.65224026582676 0.037264743077893 no 3201 0.0492427905159132 4550 689533 SGTC_1029 k015-0030 64.7 µM -1.65334963711618 0.0371673139622195 no 3202 0.0491298631640937 4588 2208316 SGTC_2734 clemastine 41.6 µM -1.65345630755649 0.0371579567469945 no 3203 0.0491190156617204 4640 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1228 0124-0032 52.5 µM -1.65373201708946 0.03713378020709 no 3204 0.0490909871423646 4579 X1228 SGTC_3163 9099914 49.47 µM -1.65407433491848 0.0371037807796354 no 3205 0.0490562050298095 4655 16268368 SGTC_1082 camptothecin 424.86 nM -1.65436161783264 0.0370786196910588 no 3206 0.049027030081398 4446 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2465 5809242 33.21 µM -1.65516592816763 0.037008249977374 no 3207 0.0489454222586053 4630 2731748 SGTC_1763 st044482 94.5 µM -1.66335913055494 0.0362976224474052 no 3208 0.0481202844509157 4555 88505 SGTC_799 1310-0557 151 µM -1.66466134764744 0.0361857117380051 no 3209 0.0479901692654171 4593 5354492 SGTC_1486 3970-0793 4.53 µM -1.66851605867217 0.0358560981261496 no 3210 0.0476066633917793 4615 2844330 SGTC_226 1,3-diallylurea 8.28947 mM -1.67486815955238 0.0353183040681654 no 3211 0.046980051025134 4555 74537 YKL182W FAS1 SGTC_2439 5492030 7.2 µM -1.67713416456457 0.0351280633963167 no 3212 0.0467581246774336 4593 5722370 SGTC_1529 apigenin 74 µM -1.68055454577248 0.0348425010675572 no 3213 0.046424735517213 4569 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2682 pyrogallin 40.03 µM -1.68592405056626 0.0343980559301379 no 3214 0.0459052144472982 4596 822798 An ATP competetive kinase inhibitor. SGTC_974 1326-0144 138 µM -1.68618205500408 0.0343768182053122 no 3215 0.0458803695893101 4588 5411856 SGTC_3120 9124077 49.47 µM -1.6922193139942 0.0338829273885929 no 3216 0.0453020826480761 4678 18774327 YGL155W CDC43 SGTC_1865 st057639 52.2 µM -1.69248951068693 0.0338609605441408 no 3217 0.0452763392057086 4594 688818 SGTC_2987 9018338 71.43 µM -1.69585934107243 0.0335879780510896 no 3218 0.0449562606185797 4594 5055682 SGTC_3243 9134147 49.47 µM -1.69833078732045 0.0333889251839536 no 3219 0.044722673548061 4672 24282180 SGTC_221 trifluoperazine 10.304 µM -1.70842368002138 0.0325860910313183 no 3220 0.0437788782479291 4580 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2361 9034121 116 µM -1.70987025770564 0.0324723390882387 no 3221 0.0436449337148945 4609 6496917 SGTC_734 2023-0417 80 µM -1.71147573085603 0.0323464761059834 no 3222 0.0434966637918694 4594 3935732 SGTC_2673 kobusone 100 µM -1.71908664521445 0.0317552752779422 no 3223 0.0427992980758963 4696 6710676 An epoxy ketone and protein crosslinker. SGTC_3132 9126706 49.47 µM -1.73294534221918 0.0307016922684266 no 3224 0.0415526920519324 4606 850858 SGTC_752 1896-0090 130 µM -1.73315575317429 0.0306859219650772 no 3225 0.041533994512808 4620 772567 SGTC_954 1189-0853 2.85 µM -1.73742598733873 0.0303673146006658 no 3226 0.0411560037581008 4546 2828194 SGTC_504 lovastatin 124 µM -1.73840826073808 0.030294415077727 no 3227 0.0410694510765903 4589 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1097 itavastatin 7.23 µM -1.73997134445588 0.0301787097108819 no 3228 0.0409320248857038 4623 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_460 trequinsin 123 µM -1.75067898357001 0.0293959025392433 no 3229 0.0400006107761097 4689 5537 A vasodilator. SGTC_3205 9113483 49.47 µM -1.75770730006108 0.0288913033168 no 3230 0.0393986625527691 4581 17018033 SGTC_2783 7738165 71.43 µM -1.75909174212653 0.0287927606879901 no 3231 0.0392809636499235 4590 17201110 SGTC_1153 4055-0057 267 µM -1.7643255467722 0.0284227475615686 no 3232 0.0388385926253322 4641 882706 SGTC_1045 1348-1485 165 µM -1.76729622295974 0.0282144962528354 no 3233 0.0385893160352492 4584 6810614 SGTC_2979 9012552 45.46 µM -1.76816334994312 0.028153948668405 no 3234 0.0385167996410324 4626 17100905 SGTC_794 k038-0031 316 µM -1.77819236616771 0.0274614951471823 no 3235 0.0376861331437308 4596 6624242 SGTC_2244 6635614 200 µM -1.78770785485073 0.0268176839663409 no 3236 0.0369115769001435 4567 836499 SGTC_3198 9112019 49.47 µM -1.78972099651787 0.0266831039155031 no 3237 0.0367493876297252 4653 45595555 SGTC_1669 st015249 58.4 µM -1.78996644977545 0.0266667338263406 no 3238 0.0367296525504126 4722 722793 SGTC_279 1273-0055 2.93 µM -1.79007957987898 0.0266591916303731 no 3239 0.0367205595149544 4663 2847562 SGTC_2446 5162541 200 µM -1.80117392340834 0.0259281574020002 no 3240 0.0358377355471433 4601 1549321 SGTC_2334 9017922 200 µM -1.80493014352945 0.0256844825130292 no 3241 0.0355428070583082 4626 3163164 SGTC_1307 1187-1599 12.2 µM -1.80826994000027 0.0254694348182936 no 3242 0.0352822489734868 4650 1538471 SGTC_3070 9117005 49.47 µM -1.80921017477792 0.0254091663321115 no 3243 0.035209178756133 4701 8779016 SGTC_650 1328-0195 38 µM -1.81086724526281 0.0253032398879776 no 3244 0.035080701972549 4633 2780821 SGTC_3192 9110362 49.47 µM -1.81402068265005 0.0251026816364879 no 3245 0.0348372708049725 4614 16649480 SGTC_2417 cerulenin 830 nM -1.81705523759589 0.0249109440181281 no 3246 0.0346043279053233 4620 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1302 1159-0335 255 µM -1.82968242074567 0.0241262357838284 no 3247 0.0336487205341404 4668 649284 SGTC_2451 5856223 45.7 µM -1.84509613558557 0.0231966058006881 no 3248 0.0325117776332968 4620 2179896 SGTC_1337 1486-1011 40.3 µM -1.85855190275954 0.0224098941750909 no 3249 0.0315453399950531 4658 X1337 SGTC_1033 k072-0102 21.3 µM -1.86112247873386 0.022262190668537 no 3250 0.0313634412433275 4601 5965931 SGTC_2007 4011539 71.82 µM -1.86382124321835 0.0221080062114337 no 3251 0.0311734057525148 4625 45595301 SGTC_323 4013-0906 34.3 µM -1.86587375966112 0.021991347134321 no 3252 0.0310295148124048 4666 2910086 SGTC_2018 5133068 143 µM -1.86936704586684 0.0217939938908971 no 3253 0.0307858830473327 4613 785362 SGTC_3267 9137951 49.47 µM -1.87099419558257 0.0217025799664554 no 3254 0.0306729427781405 4672 16643986 SGTC_3196 9111891 49.47 µM -1.87109789123746 0.0216967652990284 no 3255 0.0306657569193836 4618 18891510 SGTC_2992 9074591 71.4286 µM -1.87625175582307 0.0214094194867015 no 3256 0.030310359131804 4597 17741321 SGTC_2384 9036245 200 µM -1.87789402555038 0.0213185358882062 no 3257 0.0301978319311556 4634 6462766 SGTC_235 0330-0087 5 mM -1.88569110961378 0.0208914825527844 no 3258 0.0296682958128565 4680 46494818 YHR062C RPP1 SGTC_1999 st074831 12.5 µM -1.8917046312772 0.0205670829750337 no 3259 0.029265172970507 4636 17112523 SGTC_1387 3342-1166 1.8 µM -1.89898162341098 0.0201802413920939 no 3260 0.0287834461028712 4671 3418228 SGTC_1898 st060199 18.6 µM -1.90040883227308 0.0201050997774289 no 3261 0.0286897443702616 4671 688866 SGTC_146 3448-8650 53.125 µM -1.90469672781949 0.0198807708132978 no 3262 0.0284097523016946 4620 2891488 YIL048W NEO1 SGTC_1038 k292-0204 154 µM -1.91116193782767 0.0195465492742411 no 3263 0.0279918867767863 4604 4454212 SGTC_767 0929-0023 86 µM -1.91369087712562 0.0194171193589848 no 3264 0.0278298327080924 4679 1204563 SGTC_2332 7982454 138.89 µM -1.92065881505495 0.0190642646663505 no 3265 0.0273873675180688 4568 2981748 SGTC_383 2324-0395 7.37 µM -1.92160516115857 0.0190167650797293 no 3266 0.0273277293441196 4641 3146421 SGTC_124 0136-0217 7.121 µM -1.92202804150887 0.0189955721661891 no 3267 0.0273011147094111 4705 3976905 SGTC_1013 4112-3890 241 µM -1.9326938332548 0.0184676536819638 no 3268 0.0266369626630104 4653 705171 SGTC_1622 st003707 19.4 µM -1.94627358264102 0.0178136306391931 no 3269 0.0258109425645753 4662 10140899 SGTC_2280 7785178 200 µM -1.95174932517221 0.017555555683974 no 3270 0.0254839866620655 4663 2954328 SGTC_2981 9013952 38.96 µM -1.95598212899188 0.017358254532683 no 3271 0.025233629680789 4603 2996344 SGTC_1364 1653-0028 37.6 µM -1.96497541771652 0.0169453348018956 no 3272 0.024708541390906 4690 5718652 SGTC_1696 st025591 34.7925 µM -1.97390861823392 0.0165435174082799 no 3273 0.0241960673192479 4661 2787147 SGTC_1227 3909-8010 46.6 µM -1.98203102712491 0.016185275946086 no 3274 0.0237378840691665 4687 15982272 SGTC_1670 st016595 4.04 µM -1.99727769389751 0.0155307427300008 no 3275 0.0228975125550559 4703 597879 SGTC_1386 3228-0095 33.8 µM -2.00441741319377 0.0152321315194866 no 3276 0.0225126827699312 4684 870181 SGTC_2883 9059145 45.46 µM -2.00464550689011 0.0152226736041956 no 3277 0.0225004790016497 4682 16476510 SGTC_3158 9100007 49.47 µM -2.01385698800028 0.014844911876865 no 3278 0.0220122752471857 4692 19297233 SGTC_399 oxolinic acid 75 µM -2.04251925583304 0.013720605231616 no 3279 0.0205500256701864 4681 4628 A DNA gyrase inhibitor. SGTC_2283 7944793 200 µM -2.05416101123721 0.0132853726013042 no 3280 0.0199800552987574 4663 2970533 SGTC_1730 st033808 45.1 µM -2.06521276211324 0.012883284207403 no 3281 0.0194514367580966 4641 1045166 SGTC_741 4582-0002 126 µM -2.07428706851752 0.0125610506642253 no 3282 0.0190263290343346 4715 2912688 SGTC_3012 9080433 71.4286 µM -2.08280059040839 0.0122650982981986 no 3283 0.0186347018770312 4697 17688859 SGTC_1129 3453-1384 223 µM -2.08652471639769 0.0121375493730472 no 3284 0.0184655593557759 4665 1084452 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.09151100528456 0.0119685735079417 no 3285 0.0182411404675332 4667 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_733 4069-0007 56.1 µM -2.10313222891489 0.0115826512236735 no 3286 0.0177271061967181 4696 5717425 YNL287W SEC21 SGTC_1381 2324-0066 62.1 µM -2.10413411476043 0.0115498918453988 no 3287 0.0176833748702644 4709 10885928 SGTC_3145 9085516 49.47 µM -2.11095038799153 0.0113291437754197 no 3288 0.0173882881992079 4670 25236195 SGTC_2408 sulbentine 18.36 µM -2.12231772780874 0.0109691590589799 no 3289 0.0169055328844949 4595 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3123 9126162 49.47 µM -2.12569033298362 0.0108642868538555 no 3290 0.0167645261933718 4696 25239884 SGTC_830 4076-0286 57.8 µM -2.12916687101759 0.0107570972882896 no 3291 0.0166202283855392 4740 6866659 SGTC_528 3492-0019 172 µM -2.14700446713829 0.0102214850595697 no 3292 0.0158964629905993 4709 2869262 SGTC_2830 7992007 71.43 µM -2.14794807856895 0.0101938105391094 no 3293 0.0158589401852457 4651 1952075 SGTC_962 1254-0300 21.5 µM -2.14854114431445 0.0101764503958474 no 3294 0.0158353957540167 4704 7340576 SGTC_2934 9036370 36.88 µM -2.15316160553861 0.0100420817795745 no 3295 0.0156529899887413 4676 6462800 SGTC_2400 5203494 178.7 µM -2.15400045566975 0.0100178537833659 no 3296 0.0156200680914241 4646 6777674 SGTC_1826 st055655 41.6 µM -2.15591981905333 0.00996260981699352 no 3297 0.015544963306686 4711 676168 SGTC_2440 5628896 157.78 µM -2.17287374874801 0.00948607386337103 no 3298 0.0148949103693237 4710 5522048 SGTC_350 k064-0020 19.8 µM -2.18232022564118 0.00922929919089724 no 3299 0.0145429536555133 4712 2790705 SGTC_348 k064-0012 10.7 µM -2.19893513217026 0.00879240740055976 no 3300 0.0139412675424184 4705 5066323 SGTC_1724 st037281 8.293 µM -2.21545377670637 0.00837612578521276 no 3301 0.0133644668429118 4690 574124 YDL195W SEC31 SGTC_167 3672-0051 66.205 µM -2.22093282278042 0.00824192381761778 no 3302 0.0131777558547021 4675 3237971 SGTC_2864 9034755 47.6 µM -2.22692475334477 0.00809732498990941 no 3303 0.0129761515921591 4700 4930451 SGTC_691 1548-0686 185 µM -2.23013636158501 0.00802074317958228 no 3304 0.01286919575112 4724 46495133 SGTC_1130 3454-2858 15.9 µM -2.23385380393338 0.00793289527352945 no 3305 0.0127463470034606 4692 715628 YIL048W NEO1 SGTC_2012 4023501 200 µM -2.24078205729362 0.00777142756059562 no 3306 0.01252009787357 4710 3477460 SGTC_2984 9022109 38.96 µM -2.25583052083157 0.00743064171007101 no 3307 0.0120406235635391 4726 6459207 SGTC_3078 9116413 49.47 µM -2.32500695160628 0.00602781940100493 no 3308 0.0100357942448806 4724 17177322 SGTC_1870 st057514 26.5 µM -2.32838917228346 0.00596569251298089 no 3309 0.00994572404071269 4743 5393161 SGTC_1017 4239-0030 168 µM -2.35069228586103 0.00557004259455505 no 3310 0.00936926151258613 4742 1149593 SGTC_3007 9078383 71.4286 µM -2.37261704621977 0.00520399939745365 no 3311 0.00883128298392065 4756 6496995 SGTC_1574 spiramycin 23.7 µM -2.3863758426025 0.0049853712001509 no 3312 0.00850767585675622 4730 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2368 9071271 200 µM -2.38712825981041 0.00497365470432915 no 3313 0.00849028299516819 4750 27209959 SGTC_1759 st043059 70 µM -2.41278559364126 0.00458852169106704 no 3314 0.00791556463088916 4759 669426 SGTC_448 monastrol 171 µM -2.42827769017589 0.00436907790612778 no 3315 0.00758536130176841 4682 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_542 3381-0244 89.3 µM -2.43497255990697 0.00427718348147409 no 3316 0.00744645952135907 4744 1112843 SGTC_2241 6772625 37.8075 µM -2.44751901858228 0.00410961166690448 no 3317 0.00719217667340375 4619 2285411 SGTC_148 3253-0744 288.01 µM -2.45998197521763 0.00394899615649334 no 3318 0.00694719968903502 4705 6893655 SGTC_881 0833-0569 170 µM -2.46017866908368 0.00394650698738431 no 3319 0.00694339318032553 4769 5418700 SGTC_2587 piperic acid 92.2 µM -2.50733058437275 0.0033888203921048 no 3320 0.00608234402354833 4731 5370536 SGTC_1361 1608-0041 5.61 µM -2.52046459574416 0.00324663990174015 no 3321 0.00586000138970564 4766 X1361 SGTC_237 nikkomycin 200 µM -2.55567644401689 0.00289155904055625 no 3322 0.00529908072107373 4778 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_800 3448-7362 155 µM -2.56649587308072 0.0027897132043699 no 3323 0.00513659238684859 4789 15991913 SGTC_2813 7971799 71.43 µM -2.58818643120697 0.00259522624278706 no 3324 0.00482413730984453 4745 2234054 SGTC_2688 kanamycin b 96.69 µM -2.60321718614024 0.002467731334036 no 3325 0.00461767141365733 4717 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_341 1486-1430 230 µM -2.60898849103876 0.00242030220964275 no 3326 0.00454051482403298 4750 2054753 YPL210C SRP72 SGTC_2091 4-phenylthiadiazole 200 µM -2.61863459486085 0.00234286797479728 no 3327 0.0044141228415613 4776 270010 SGTC_3134 9127454 49.47 µM -2.67799768008326 0.00191372861797698 no 3328 0.00370318656586336 4770 24262820 SGTC_1737 st035557 69.7 µM -2.75395869637301 0.00146902808224906 no 3329 0.00294395991443262 4713 5716916 SGTC_3003 9075612 71.4286 µM -2.75914427232704 0.00144241642503768 no 3330 0.00289764717780755 4779 6501993 SGTC_2026 5148700 152 µM -2.76903643840714 0.00139286810472785 no 3331 0.00281111734763068 4777 79838 SGTC_1062 mesoridazine 14.2 µM -2.78314387245244 0.00132489270119481 no 3332 0.00269174638471089 4799 4078 A neuroleptic. SGTC_2124 5246320 200 µM -2.80771932491849 0.00121367836014958 no 3333 0.00249468458499598 4788 579342 SGTC_3317 9138495 8.753 µM -2.85816478702283 0.0010116961192854 no 3334 0.00213049524074778 4775 17020139 SGTC_1304 1165-0502 251 µM -2.86702472828363 0.000979583381034753 yes 3335 0.00207175317818427 4796 767425 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -2.89027994069408 0.000899695045522372 yes 3336 0.0019244945237463 4749 5355888 SGTC_3256 9138902 49.47 µM -2.93026719043499 0.00077618981710736 yes 3337 0.00169335330749714 4809 17228773 SGTC_918 glabranin 770.725 nM -2.94214274910384 0.00074263807657225 yes 3338 0.0016297481784994 4782 124049 Also referred to as licorice root. SGTC_58 0957-0393 9 µM -3.03476224537159 0.000523369607991807 yes 3339 0.0012036268610198 4454 6997992 SGTC_920 mycophenolic acid 780.421 nM -3.19939506521255 0.000274537621095701 yes 3340 0.000688581552534786 4784 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_795 0685-0265 78 µM -3.27737963561841 0.00020014913204839 yes 3341 0.000523876956782385 4793 302754 SGTC_2618 avocadyne 43.43 µM -3.32249640291067 0.000166196274854425 yes 3342 0.000446079108170303 4793 3015189 SGTC_1526 st051518 75 µM -3.34967311457801 0.000148429428611757 yes 3343 0.000404534900869998 4793 673993 SGTC_1523 st012844 44.7 µM -3.38022176224365 0.0001305880509037 yes 3344 0.000362136829406165 4798 4274103 SGTC_1838 st055369 84.5 µM -3.39968112386793 0.000120293534357413 yes 3345 0.000337322404030162 4801 676036 SGTC_1897 st060201 15 µM -3.49065255537027 8.14917736338019e-05 yes 3346 0.000240921215847466 4806 611878 SGTC_3005 9076496 71.4286 µM -3.52804633461419 6.92529838752141e-05 yes 3347 0.000209319434959312 4805 21368410 SGTC_796 1234-0020 70.7 µM -3.5436038052257 6.46898269848117e-05 yes 3348 0.000197348947725305 4795 46495034 SGTC_814 3342-0569 96 µM -3.62968764012576 4.41496343845971e-05 yes 3349 0.00014188219674813 4808 4346283 SGTC_1848 st056003 16.4 µM -3.71810426831804 2.9566272848874e-05 yes 3350 0.000100361712466047 4796 146492 SGTC_2789 5281112 71.43 µM -3.80352020110404 1.99059931909702e-05 yes 3351 7.13271773185905e-05 4799 765948 SGTC_2529 gangaleoidin 93.61 µM -3.81339323777589 1.90062545389569e-05 yes 3352 6.85358763773974e-05 4807 4565183 SGTC_1846 st056244 14.8 µM -3.87169349726268 1.44316984372787e-05 yes 3353 5.40409038925927e-05 4799 5393182 SGTC_1358 1509-0022 2.48 µM -4.31182995799579 1.59666276675189e-06 yes 3354 8.09544659645381e-06 4809 3258434 SGTC_530 4358-1714 28 µM -4.52235909673189 5.15760829732181e-07 yes 3355 3.05770976124118e-06 4807 1564641 SGTC_2623 humulene 100 µM -4.63890840156151 2.70036190182525e-07 yes 3356 1.75127117902402e-06 4801 6187145 An anti-inflammatory.