SGTCid condition conc unit SRB7|YDR308C.score SRB7|YDR308C.strain.pval SRB7|YDR308C.strain.significant SRB7|YDR308C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_937 3122-0005 46.7 µM 5.67445726181946 3.19873580054436e-10 yes 1 6.95645225219141e-09 1 759535 SGTC_1203 3992-3522 103 µM 5.4213622360159 1.7669719640649e-09 yes 2 2.9573284791037e-08 4 5322312 SGTC_762 1165-0429 115 µM 4.49639020553253 4.86047704110115e-07 yes 3 3.45584219139169e-06 3 5967793 SGTC_1745 st081495 74 µM 3.94862695545478 8.51678329136793e-06 yes 4 3.93003638132477e-05 35 13842402 YBL026W LSM2 SGTC_2436 5633522 8.09 µM 3.76409048066089 2.06923160543678e-05 yes 5 8.35781781490806e-05 15 5724242 SGTC_2454 5-benzylidenerhodanine 10.36 µM 3.69492345243021 2.85754165031861e-05 yes 6 0.000109976520968566 6 1273210 SGTC_2126 5251174 33.877 µM 3.64374701640465 3.61576771350894e-05 yes 7 0.000134348766397765 11 790722 SGTC_227 fluconazole 33.516 µM 3.63851203655104 3.70325107097652e-05 yes 8 0.00013710890700821 53 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_934 2950-0684 338 µM 3.60316012665869 4.34855768112695e-05 yes 9 0.000157185863410211 7 1121253 SGTC_1619 st003326 88.7 µM 3.56582920470226 5.14454856729805e-05 yes 10 0.000181353770381782 6 2849032 SGTC_2002 4023503 131 µM 3.54209529141983 5.72011412662701e-05 yes 11 0.000198481021683441 13 4736863 YCR052W RSC6 SGTC_882 0843-0131 351 µM 3.54131686403251 5.73998313518223e-05 yes 12 0.000199067568085056 15 5425421 SGTC_2852 9023854 51.95 µM 3.4498766100024 8.58508461206831e-05 yes 13 0.000280421417614976 8 19798528 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 3.4149407564041 9.98763308553659e-05 yes 14 0.000318979428321267 7 91467 include heat shock SGTC_1167 k781-0610 148 µM 3.21319406669008 0.000232983745170764 yes 15 0.000656337803899177 16 4525169 SGTC_1465 k213-0056 144 µM 3.19067569703107 0.000255362234148007 yes 16 0.000709702538700292 22 24048857 YMR208W ERG12 SGTC_2647 atorvastatin 60.16 µM 3.10387764454102 0.000361730379607818 yes 17 0.000955011513917846 7 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_104 0074-0074 590.992 µM 3.06877838088673 0.000415433741076655 yes 18 0.00107467986230667 31 3943124 SGTC_2432 5630864 12.22 µM 2.95933136655229 0.000634065664582628 yes 19 0.00154153693670951 21 5714970 SGTC_1604 st002052 72.4 µM 2.95745312507828 0.000638609118977966 yes 20 0.00155095954084742 15 6254834 YHR062C RPP1 SGTC_1143 3454-2408 5.08 µM 2.94948410411031 0.000658222370617866 yes 21 0.00159152473442807 10 X1143 SGTC_2879 9041815 71.43 µM 2.92948458135938 0.000709918554562504 yes 22 0.00169762328523417 4 4942971 SGTC_2010 4012422 159 µM 2.90884093963215 0.000767184550685199 yes 23 0.00181385689581943 11 952393 SGTC_550 4123-0385 25.7 µM 2.85335205865721 0.000942852156669007 yes 24 0.00216303327590726 17 5731123 SGTC_2650 prasterone 100 µM 2.83838199836109 0.000996202445977308 yes 25 0.002267144072684 9 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3040 9091894 49.47 µM 2.82471748754871 0.00104730447707331 no 26 0.00236611601396386 20 25236966 SGTC_1345 1488-0192 31.4 µM 2.76862995585277 0.00128324203487267 no 27 0.00281462653287818 12 658348 SGTC_249 wiskostatin 11.211 µM 2.75955817516743 0.00132567912054858 no 28 0.00289397904343576 11 2775510 A n-wasp and actin depolymerizer. SGTC_2307 7538926 6.34 µM 2.74494387335774 0.00139674837664486 no 29 0.00302606237588086 49 96582 SGTC_831 k061-1017 217 µM 2.7410084555697 0.00141647211296792 no 30 0.00306254656109439 32 1240153 SGTC_1798 st045719 60.953 µM 2.71396707502517 0.00155902384545383 no 31 0.00332413867442486 20 3980186 SGTC_1611 st001856 99.4 µM 2.71051917082506 0.00157811090147254 no 32 0.00335889824976981 29 647478 SGTC_365 0121-0052 13.6 µM 2.70839887451292 0.00158995405252589 no 33 0.00338043562232805 21 3101739 SGTC_942 3253-1115 227 µM 2.66098760116526 0.00187685175260338 no 34 0.00389559130455616 32 46497897 SGTC_2769 toremifene 3.73 µM 2.62502021819076 0.00212505347912344 no 35 0.00433219110990839 27 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_758 0868-0029 16 µM 2.61366038530468 0.00220941837569382 no 36 0.00447890144796332 12 762687 SGTC_3073 9114972 49.47 µM 2.61179992387176 0.00222352099795379 no 37 0.00450334735241711 22 41905075 SGTC_2488 5268135 45.7 µM 2.61170745062639 0.00222422408463242 no 38 0.00450456552538733 32 1270356 YLR208W SEC13 SGTC_554 4483-2211 187 µM 2.60076511148112 0.00230885654616941 no 39 0.00465080586900501 15 747107 SGTC_1414 3917-0015 5.4 µM 2.56828073077863 0.00257755952365635 no 40 0.0051102174332491 14 6618702 SGTC_154 3389-1638 511.116 µM 2.56581510178772 0.0025990654770274 no 41 0.00514668406351438 29 5238686 SGTC_2876 9059903 25.97 µM 2.56314311742793 0.00262255426088403 no 42 0.00518646402300794 20 6916095 SGTC_2237 6667747 47.222 µM 2.54534447689898 0.00278397290557484 no 43 0.00545849910948608 18 729940 YDL015C TSC13 SGTC_1125 tnp00248 1.32998 µM 2.53244587780293 0.00290649759944332 no 44 0.00566349272719972 38 24207736 SGTC_2669 eugenol 100 µM 2.53199000796034 0.00291091554554508 no 45 0.00567086115968044 8 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_230 MPP+ 141.667 µM 2.52118521361518 0.00301741546975275 no 46 0.00584801356555182 29 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1912 st060209 90.8 µM 2.51659643185218 0.00306369829105366 no 47 0.00592472344638219 35 688787 SGTC_1012 4112-3522 18 µM 2.51183950760434 0.00311235100347486 no 48 0.00600518480534093 21 3112398 SGTC_1923 st058458 19.1 µM 2.49596012668023 0.00327983887380578 no 49 0.00628083604205506 40 3534982 SGTC_2625 euphol 100 µM 2.4606069378506 0.00368217289127858 no 50 0.00693511149830508 35 6708538 A triterpene alcohol. SGTC_2648 atorvastatin 78.68 µM 2.45929558468989 0.00369791375584086 no 51 0.00696049746565967 26 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1117 retinoic acid 1.10837 µM 2.44452715958927 0.00387940008292104 no 52 0.00725210798256739 19 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1450 4112-4260 37.6 µM 2.42985009349798 0.00406763041400259 no 53 0.00755253445161976 26 1633175 SGTC_264 promethazine 12.5 mM 2.41362659814893 0.00428516985596042 no 54 0.00789731989127481 57 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1560 lithocholic acid 53.1 µM 2.40618446525279 0.00438839633259459 no 55 0.00806006138143447 15 9903 A bile acid which acts as a detergent. SGTC_526 4469-0568 170 µM 2.40538066710665 0.00439967734644682 no 56 0.00807781367803443 38 2901964 SGTC_2311 7694451 200 µM 2.40529085004053 0.00440093950419346 no 57 0.00807979946723201 49 2163142 SGTC_603 3794-0023 45.9 µM 2.37560856647809 0.0048362013161235 no 58 0.00876001876437789 18 3802260 SGTC_67 0335-0847 266 µM 2.37322237377287 0.00487280544637268 no 59 0.00881682195625057 60 4552207 YOR254C SEC63 SGTC_1426 4048-4480 71.7 µM 2.36354650801955 0.00502377629151366 no 60 0.00905047727076121 21 14224343 SGTC_205 1486-1330 71.903 µM 2.34608930719291 0.00530672551259452 no 61 0.00948578055285932 32 4118834 SGTC_309 k408-0051 1.48 µM 2.3246134886266 0.00567419329609898 no 62 0.0100463184431134 73 3640463 SGTC_713 1488-1073 324 µM 2.32347692342751 0.00569425554335502 no 63 0.0100767729701368 24 3312542 SGTC_376 3970-0862 59.1 µM 2.30232132213412 0.00607935672567043 no 64 0.0106585291262738 51 3135186 SGTC_1090 efavirenz 20.7 µM 2.2918203663504 0.00627894496816016 no 65 0.0109580054742666 36 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1630 st005209 31.3 µM 2.29046545076681 0.00630511547435525 no 66 0.0109971745797075 29 3367314 SGTC_217 ketoconazole 989 nM 2.28837345399184 0.00634571254251417 no 67 0.0110578910991098 32 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_637 1181-0519 7.26 µM 2.28794185946474 0.00635411675319654 no 68 0.0110704535882513 45 6252091 YGR060W ERG25 SGTC_75 0159-0059 199.013 µM 2.28142901740899 0.00648213921972903 no 69 0.0112615362954052 47 5377270 SGTC_29 0299-0004 12.984 µM 2.27377541749089 0.00663549750336313 no 70 0.0114897464991424 17 16871 A napthoquinone isolated from Swertia calycina. SGTC_124 0136-0217 7.121 µM 2.25950758189952 0.00692997036135295 no 71 0.0119259146088687 68 3976905 SGTC_2088 5278280 127.392 µM 2.22983550562918 0.00757955709654813 no 72 0.0128791826532544 32 791502 SGTC_1851 st056236 18.9 µM 2.22134828034348 0.00777496325284973 no 73 0.0131636905754709 39 5393171 SGTC_1135 dihydrocapsaicin 536.708 nM 2.2111696363254 0.00801514721187851 no 74 0.0135120460889721 35 107982 A Capsaicinoid. SGTC_556 4058-0063 51.5 µM 2.21107576770865 0.00801739223755106 no 75 0.0135152953440945 27 6615692 SGTC_2929 9013348 24.6 µM 2.21062890447602 0.00802808730415679 no 76 0.0135307727310667 29 2995952 SGTC_1691 st019933 84.6 µM 2.20816756507963 0.00808722121596551 no 77 0.0136162972509834 31 6176082 SGTC_933 2914-0560 114 µM 2.20337471026998 0.00820346939474633 no 78 0.0137841745781415 36 463887 SGTC_641 4092-0595 30 µM 2.20241346147857 0.00822695991551006 no 79 0.0138180579267372 52 786260 SGTC_398 bronopol 33.3 µM 2.19121155200844 0.00850509373653984 no 80 0.0142182435136561 53 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2831 7999036 19.48 µM 2.18515736325674 0.00865882215543239 no 81 0.0144386552462181 45 2988270 SGTC_1489 4065-0444 182 µM 2.18434389722543 0.00867966235616643 no 82 0.0144684937037353 24 2877968 SGTC_3160 9100216 49.47 µM 2.1675350103636 0.00912024414185871 no 83 0.0150970415699076 19 17191039 SGTC_2805 7950783 58.44 µM 2.15659417893924 0.00941742818331137 no 84 0.0155186492482713 47 1178958 YDL195W SEC31 SGTC_712 r015-0009 80.6 µM 2.15349280641941 0.00950319632388909 no 85 0.0156399844212107 29 6813872 YLR060W FRS1 SGTC_1974 st069448 26.9 µM 2.14872845064776 0.00963628461593485 no 86 0.0158279660119111 34 6323587 YNR016C ACC1 SGTC_1700 st030840 7.9285 µM 2.14271731198651 0.00980652275549029 no 87 0.0160679022040839 55 5499307 SGTC_1606 st000094 49.2 µM 2.13159736690428 0.0101283780158154 no 88 0.0165199802031262 52 1242210 SGTC_1220 1838-0075 193 µM 2.13091295142284 0.0101484853943948 no 89 0.0165481571011001 34 5529645 SGTC_2620 irigenin 100 µM 2.11028013400399 0.0107712260482109 no 90 0.0174171168545004 66 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_907 3448-6986 75.5 µM 2.10637806452745 0.0108926679414029 no 91 0.0175857625745361 47 590582 SGTC_374 0880-0231 82.3 µM 2.10476836975221 0.010943111678399 no 92 0.0176557378806858 53 6833587 SGTC_548 1436-0017 110 µM 2.09725904199468 0.0111811298729286 no 93 0.0179853252316869 49 9677137 SGTC_1395 3486-0190 4.35 µM 2.09344881150692 0.0113036124506931 no 94 0.0181545545046626 40 6748079 SGTC_1708 st033234 31.827 µM 2.0889748773155 0.0114489172526116 no 95 0.0183549923546856 44 674664 SGTC_1349 flufenamic acid 69 µM 2.08814965011415 0.0114758955688612 no 96 0.0183921687543186 43 3371 A non-steroidal anti-inflammatory. SGTC_1755 st041960 45.185 µM 2.08581278633117 0.0115525920855982 no 97 0.0184977923693439 52 2257073 SGTC_2861 9024595 19.48 µM 2.08040883805144 0.0117316580124548 no 98 0.018744024652378 15 16482810 SGTC_156 3474-0145 5.642 µM 2.07852337076074 0.0117946994946893 no 99 0.0188305903199183 42 2265471 SGTC_1343 1487-0095 224 µM 2.06085743739092 0.0123997880336254 no 100 0.0196583214467761 42 4560101 YGL055W OLE1 SGTC_2192 5915882 198.485 µM 2.06039330844763 0.012416041202164 no 101 0.0196804780472259 59 2876149 SGTC_1656 st012921 11 µM 2.05092782005238 0.0127515580048878 no 102 0.0201369882243505 37 6732821 SGTC_1948 st076329 66.6 µM 2.04785592892573 0.0128621181696202 no 103 0.0202870591245596 32 24208413 SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.04646954963058 0.0129122861351804 no 104 0.0203550977037837 59 165506 SGTC_1388 3346-4487 254 µM 2.04638782971403 0.0129152485522052 no 105 0.0203591142565965 43 3345614 SGTC_33 0986-0033 35.816 µM 2.04192110594573 0.0130780676555133 no 106 0.0205796789059258 20 2848082 SGTC_275 trichlorophene 5.69 µM 2.03800092970585 0.0132224230447895 no 107 0.0207749199473238 41 62616 SGTC_2667 digitoxin 100 µM 2.02660614180932 0.0136498634581383 no 108 0.0213513539757469 21 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.01487687949583 0.0141022517146748 no 109 0.0219587755469325 76 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_938 3126-1755 342 µM 2.01398695607879 0.0141370966905031 no 110 0.0220054514950668 30 1777771 SGTC_458 nppb 133 µM 2.01102518574663 0.0142535997160351 no 111 0.0221613982590737 23 4549 A chloride channel blocker. SGTC_45 0kpi-0036 14.9 µM 2.01001826870641 0.0142933953293335 no 112 0.0222146276813465 44 2795021 SGTC_46 0329-0187a 2.197 µM 1.99621005189307 0.0148488552740282 no 113 0.0229555318904109 64 46494817 SGTC_279 1273-0055 2.93 µM 1.99370524523259 0.0149515798607638 no 114 0.0230921379170574 49 2847562 SGTC_1261 0712-0010 12.7 µM 1.98958130819213 0.015122037536284 no 115 0.023318538444626 58 2840123 SGTC_2871 9038510 12.99 µM 1.98856999615817 0.0151640928825261 no 116 0.0233743429399823 71 4945164 SGTC_384 k007-0144 5.16 µM 1.98660044740178 0.0152462849092492 no 117 0.0234833458058871 72 6824886 SGTC_3032 9089427 49.47 µM 1.98559620005545 0.015288340656099 no 118 0.0235390893690977 40 17173707 SGTC_1210 3013-0140 750 nM 1.98371829223883 0.0153672508424628 no 119 0.0236436265994132 42 905973 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.97274423188395 0.0158354113756082 no 120 0.0242623548979242 70 5282362 SGTC_1423 4048-0112 5.59 µM 1.96273310852362 0.0162731082900046 no 121 0.0248385969563226 52 X1423 SGTC_1308 1187-1617 41.4 µM 1.95535364453266 0.0166023440678032 no 122 0.0252706717537089 63 2882570 SGTC_277 nystatin 15.5 µM 1.94344577621432 0.0171456338855806 no 123 0.0259811604649827 53 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_286 k060-0067 22.9 µM 1.92889086556542 0.0178302622504537 no 124 0.0268722060280536 67 5985051 SGTC_1312 1218-2183 165 µM 1.92804350713121 0.0178708283389696 no 125 0.0269248574101963 55 6744073 SGTC_710 3448-4187 58 µM 1.92695880037429 0.0179228720020466 no 126 0.0269923822961258 64 3946412 SGTC_1236 0330-0013 258 µM 1.91770734682873 0.0183720273562497 no 127 0.0275740648240851 43 4617066 SGTC_1732 st034308 51.822 µM 1.90603333516281 0.0189524489986208 no 128 0.0283229404146265 69 830119 SGTC_2602 kawain 100 µM 1.90590672975982 0.0189588282309224 no 129 0.028331153886953 58 5369129 SGTC_420 mitomycin C 81.9 mM 1.9039880711735 0.0190557269393442 no 130 0.0284558688875134 72 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_887 0885-0007 9.62 µM 1.89984717460854 0.0192662921341171 no 131 0.0287265890345544 78 5719458 SGTC_3207 9114163 49.47 µM 1.89823187270159 0.0193489649508981 no 132 0.0288327719634921 76 849233 SGTC_749 1000-0129 128 µM 1.89592442558738 0.0194675852043532 no 133 0.028985019288759 56 708470 SGTC_2053 5265679 138 µM 1.89533728444411 0.0194978671084485 no 134 0.0290238658117391 62 764595 SGTC_3068 9116768 49.47 µM 1.89068455662312 0.0197392500526757 no 135 0.0293332325966691 65 41904888 SGTC_2863 9028737 58.44 µM 1.88367240687812 0.0201078295349698 no 136 0.0298046505170021 32 6460917 SGTC_1950 st077106 7.18 µM 1.88014186157484 0.0202956041765507 no 137 0.0300443732966023 59 13831864 SGTC_978 1416-0512 87.4 µM 1.87798726449792 0.0204109267885164 no 138 0.0301914536639601 54 6814003 SGTC_179 1273-0063 6.77 µM 1.8719379677561 0.0207376815755436 no 139 0.0306075930220528 38 3108139 SGTC_323 4013-0906 34.3 µM 1.86598860033055 0.0210633482898852 no 140 0.0310214802095711 44 2910086 SGTC_2143 5623677 140.463 µM 1.86311235361817 0.0212223385989432 no 141 0.0312232302642547 50 5375313 SGTC_1788 fluconazole 20 µM 1.85594121678528 0.0216231632653629 no 142 0.0317309686244481 67 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_849 0386-0493 241 µM 1.84937307072664 0.0219958787198741 no 143 0.0322019805821565 60 726119 SGTC_2011 4012611 177 µM 1.84624635085159 0.0221752041378564 no 144 0.0324282218207657 66 2049887 SGTC_263 alizarin 107.927 µM 1.8367944362403 0.022724814156015 no 145 0.0331201237966553 87 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_704 1310-0270 142 µM 1.83508629427317 0.0228253541638695 no 146 0.0332464521798435 51 5718033 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.83119447970584 0.0230558240161644 no 147 0.033535760194386 50 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1488 4013-0813 75.9 µM 1.82341928953006 0.0235221355140749 no 148 0.0341199554857616 49 2910057 SGTC_3069 9117009 49.47 µM 1.81889020480113 0.0237974028533385 no 149 0.0344640912667541 36 41904981 SGTC_888 0916-0002 6.97 µM 1.80927043654888 0.0243910626800401 no 150 0.0352044997573709 54 2802138 YIL048W NEO1 SGTC_2342 7990637 118.86 µM 1.80787109265853 0.0244784469026045 no 151 0.0353132828912368 91 2033102 YER133W GLC7 SGTC_961 1252-1571 372 µM 1.80673311898192 0.0245497030540139 no 152 0.0354019505865553 78 6813498 SGTC_2968 9090663 33.37 µM 1.80620712585269 0.0245826977860238 no 153 0.035442996139264 105 25236811 SGTC_1716 st033144 30.6155 µM 1.80445598556682 0.0246928123848137 no 154 0.0355799265969863 63 674617 SGTC_443 clozapine 122 µM 1.79516052950086 0.0252842770738914 no 155 0.036314063561607 45 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1861 st057647 17.4 µM 1.78918437096399 0.0256707704297752 no 156 0.0367925639238811 63 688668 SGTC_2439 5492030 7.2 µM 1.78494001319277 0.025948257176613 no 157 0.0371355237347407 67 5722370 SGTC_715 0868-0130 184 µM 1.78222869030919 0.0261268276164545 no 158 0.0373559729845234 44 2876258 SGTC_3208 9114115 49.47 µM 1.78118715151635 0.0261956970714506 no 159 0.0374409409674821 104 650895 SGTC_5 0352-0601 109.883 µM 1.77813393848684 0.0263984592508299 no 160 0.0376909298003329 61 762456 SGTC_3260 9137109 49.47 µM 1.76584304434309 0.0272280050239711 no 161 0.0387110923777055 47 17478346 SGTC_2829 7992743 58.44 µM 1.75805840161234 0.0277645763243001 no 162 0.0393687863903068 54 16462845 SGTC_1698 5-fluorocytosine 1.055 µM 1.75666223730109 0.0278617353571729 no 163 0.039487698895009 78 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1996 st072960 66.8 µM 1.7553816223571 0.0279511022022124 no 164 0.039597026701351 71 1719405 SGTC_1999 st074831 12.5 µM 1.74830259018476 0.0284494255616809 no 165 0.0402058224861133 84 17112523 SGTC_1752 st044819 83.042 µM 1.74816903278148 0.0284588978254772 no 166 0.0402173810730054 76 441209 YML126C ERG13 SGTC_1519 esterone 74 µM 1.7423781213561 0.0288721358197826 no 167 0.0407211508480039 68 698 A steroid. SGTC_2702 st077768 96.8 µM 1.73934768109546 0.0290903677716307 no 168 0.0409868125259592 53 6484119 SGTC_1132 3456-3614 2.5 µM 1.73243171327526 0.0295935455740043 no 169 0.0415983627918053 70 3125502 SGTC_1855 st056195 39.6 µM 1.73112231797233 0.0296896205399644 no 170 0.0417149752953274 66 4028379 SGTC_631 k072-0230 41.5 µM 1.73107511106176 0.0296930891060691 no 171 0.0417191844017731 75 5773147 SGTC_800 3448-7362 155 µM 1.726750686395 0.0300122589435282 no 172 0.0421062241887665 138 15991913 SGTC_2393 9031399 185.94 µM 1.71763203130354 0.0306946021247524 no 173 0.0429318769868241 88 1526623 YDL150W RPC53 SGTC_2447 5741742 33.78 µM 1.71721868077601 0.030725834764709 no 174 0.0429696117783796 83 1776504 SGTC_386 1509-0011 3.07 µM 1.70911090142375 0.031343794972769 no 175 0.0437152043194881 65 3107280 SGTC_1627 st003713 25.6 µM 1.70317089291368 0.0318030250698646 no 176 0.0442680460398885 73 16195070 YER133W GLC7 SGTC_511 blebbistatin 171 µM 1.69610636716707 0.0323564150339654 no 177 0.0449328690292317 65 3476986 A myosin inhibitor. SGTC_1647 st011722 22.4 µM 1.68859867857139 0.0329532040587265 no 178 0.0456481820472291 86 2854783 SGTC_2857 9024691 58.44 µM 1.67408921765411 0.0341322754663015 no 179 0.0470565332631581 78 16478292 SGTC_1257 0669-0121 16 µM 1.66194054440228 0.0351459856613644 no 180 0.0482623481242911 84 4307855 SGTC_2629 bisabolol 100 µM 1.65764875383824 0.0355099537932173 no 181 0.0486941915062591 105 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3168 9103419 49.47 µM 1.65686957060433 0.0355763632502584 no 182 0.0487729238290985 47 16649256 SGTC_1370 2001-0092 44.6 µM 1.65127028051942 0.0360565885201548 no 183 0.0493416989701474 84 790957 SGTC_364 0083-0097 67.7 µM 1.64747847284003 0.0363847994251948 no 184 0.0497298687127417 79 5207356 SGTC_155 k072-0202 43.6 µM 1.6427059973276 0.0368013661914015 no 185 0.0502218886702852 85 5857737 SGTC_1181 1222-0449 220 µM 1.64146461002505 0.0369103578415436 no 186 0.0503505037838904 81 658318 SGTC_2249 haloperidol 116.36 µM 1.64072738521272 0.0369752097067691 no 187 0.0504270088032485 127 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1137 ixabepilone 100 µM 1.63794869894619 0.037220481620973 no 188 0.0507161979411773 85 154225 A novel microtubule stabilizer. SGTC_1040 k898-0338 155 µM 1.62932548398342 0.0379901202549847 no 189 0.0516220670494469 71 20969351 SGTC_3034 9090421 49.47 µM 1.62480042190031 0.0383991560208108 no 190 0.0521025455684499 49 17173761 SGTC_1304 1165-0502 251 µM 1.62463733046725 0.0384139651783586 no 191 0.0521199289860072 86 767425 SGTC_649 1123-0311 367 µM 1.62375629455526 0.0384940462259423 no 192 0.0522139155903142 90 693629 YIL048W NEO1 SGTC_2927 9011802 47.9 µM 1.61988462938368 0.0388475723231818 no 193 0.0526285311173679 71 43912568 SGTC_549 1661-1316 519 µM 1.61026093192849 0.0397377877536256 no 194 0.0536704521666785 90 2857282 SGTC_2354 9060492 162 µM 1.60210233494412 0.0405054050231521 no 195 0.0545664908841518 87 6471895 SGTC_3071 9117417 49.47 µM 1.59977333663069 0.0407267285627855 no 196 0.054824437948969 81 45595590 YGL055W OLE1 SGTC_1693 xanthone 101.9 µM 1.59728468221179 0.0409643076633331 no 197 0.0551011318433067 92 7020 An insecticide. SGTC_1501 4491-0275 38.4 µM 1.59517898019979 0.0411662051220865 no 198 0.0553361089077354 69 5104718 SGTC_357 1325-0123 420 µM 1.59165466046603 0.0415059261174857 no 199 0.0557311605099559 77 1098503 SGTC_1280 0880-0253 10.1 µM 1.59127233774529 0.0415429156724449 no 200 0.0557741496923699 86 6836607 SGTC_2932 9016711 44.54 µM 1.59071700387173 0.0415966915478528 no 201 0.0558366392192052 89 7117328 SGTC_2976 9009005 19.48 µM 1.58294307070574 0.0423554187463171 no 202 0.0567172203099471 55 2993148 SGTC_2472 5377652 49.4 µM 1.57818670629228 0.0428251287979558 no 203 0.0572613616733827 106 1610903 SGTC_541 4513-1321 94 µM 1.57805915066773 0.0428377831590474 no 204 0.0572760107604825 105 747515 SGTC_1642 st009582 77.7 µM 1.57490300201913 0.0431518575977542 no 205 0.0576394178164878 107 6739311 SGTC_449 xestospongin c 11.1929 µM 1.5708012554163 0.0435628067548865 no 206 0.0581144101924295 80 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1985 st071382 65.5 µM 1.56964830259515 0.0436788867176732 no 207 0.0582484772655985 96 6123237 SGTC_775 4577-0580 57.3 µM 1.56863105149811 0.0437815112848898 no 208 0.0583669663844262 88 2006902 SGTC_1393 3470-5649 58.2 µM 1.56700384225328 0.0439460753599823 no 209 0.0585568967600665 52 4108395 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.5608986101654 0.0445679660399549 no 210 0.059273837649241 73 17037758 SGTC_1293 1000-1278 195 µM 1.55913516977592 0.0447489070991272 no 211 0.0594821955443775 99 678847 SGTC_1988 st071872 53.4 µM 1.55848622020368 0.0448156424865931 no 212 0.0595590160122538 62 16414116 SGTC_112 phenothiazine 287.218 µM 1.55589774746987 0.0450826283714587 no 213 0.0598662045627354 77 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_524 r073-0010 27.8 µM 1.55425070609237 0.0452531764309154 no 214 0.0600623133523922 104 2772106 SGTC_2456 5770359 74.46 µM 1.55424197855638 0.045254081531547 no 215 0.0600633538548245 96 3118787 SGTC_2781 5567276 71.43 µM 1.55286391020613 0.0453971787286775 no 216 0.0602278251823969 104 2853274 SGTC_2211 7117706 200 µM 1.55227169931227 0.0454587849949967 no 217 0.0602986132821713 74 822771 SGTC_1976 st070609 63.5 µM 1.55185744663503 0.0455019186485821 no 218 0.0603481683918284 80 682556 SGTC_2614 arthonioic acid 13.39 µM 1.55132949902562 0.0455569383682047 no 219 0.0604113704827525 69 6710684 SGTC_2896 9052656 71.43 µM 1.54902928197748 0.0457972785341919 no 220 0.0606873405674216 126 6469436 SGTC_969 1313-0238 134 µM 1.54652046309456 0.0460605753667812 no 221 0.0609894609819705 131 5212874 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.5415408633633 0.0465867783938615 no 222 0.0615926027923248 81 6710655 SGTC_1337 1486-1011 40.3 µM 1.53649490169789 0.0471249040531921 no 223 0.0622085236204453 79 X1337 SGTC_2670 beta-carotene 100 µM 1.53463230899586 0.0473247946793559 no 224 0.0624370858681269 50 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3155 9099265 49.47 µM 1.53279728807782 0.0475223902443994 no 225 0.0626629045251909 90 25236499 SGTC_3021 9087658 49.47 µM 1.52658494941807 0.0481962470647661 no 226 0.0634321259463271 56 25237042 SGTC_359 0081-0058 15.9 µM 1.52286060860185 0.0486038805626809 no 227 0.0638967913613893 104 3494159 SGTC_1557 sumaresinolic acid 42.3 µM 1.52033452334857 0.0488819289915649 no 228 0.0642134607503974 69 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2595 hexamethylquercetagetin 100 µM 1.51752032526794 0.0491931854474548 no 229 0.0645676829023868 103 386331 SGTC_3044 9093193 49.47 µM 1.51183615336771 0.0498266934716872 no 230 0.0652877748122278 92 25236277 SGTC_2445 5742597 35.57 µM 1.51126724525717 0.0498904556283192 no 231 0.065360187834037 113 1774255 SGTC_3064 1327-0027 10 µM 1.51100866254093 0.0499194585996593 no 232 0.0653931219190703 64 16000455 YPR107C YTH1 SGTC_2312 7706453 155.7 µM 1.50896057864057 0.0501496496321307 no 233 0.0656544286327569 104 976098 SGTC_2785 7756463 72.73 µM 1.50622610771576 0.0504583042343468 no 234 0.0660045697513357 132 2201551 SGTC_912 3474-0017 2.18 µM 1.50555834867108 0.0505339072997043 no 235 0.0660902937815726 91 3360550 SGTC_2885 9057732 51.95 µM 1.50501156227518 0.0505958811294947 no 236 0.0661605520716189 111 6471414 SGTC_2078 5212016 200 µM 1.50307405005049 0.0508159699877699 no 237 0.0664099748479436 87 1899708 SGTC_1007 4101-0031 70 µM 1.50058395398997 0.0510999474313265 no 238 0.0667316020710685 104 1146276 SGTC_1199 1638-0010 4.46 µM 1.49311719940001 0.0519590533938944 no 239 0.0677032555606476 102 3111136 SGTC_3251 9135047 49.47 µM 1.49212767224331 0.0520737621117019 no 240 0.067832839371322 78 17682963 SGTC_2834 9001755 58.44 µM 1.49204070422663 0.0520838532938708 no 241 0.0678442374440421 96 2989575 SGTC_1529 apigenin 74 µM 1.48217507719894 0.0532387131645944 no 242 0.0691468581187321 103 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2275 7947463 200 µM 1.47991806338904 0.0535057491063097 no 243 0.069447557232851 101 1225414 SGTC_2466 5983409 37.09 µM 1.47922109677278 0.0535884240048414 no 244 0.0695406164405956 99 2879657 SGTC_1008 4106-0037 6 µM 1.47639082886598 0.0539251936633309 no 245 0.0699195016504918 112 2905394 SGTC_877 0771-0151 33.1 µM 1.46777065091021 0.0549612278645972 no 246 0.0710832660892753 101 6166523 SGTC_38 0929-0051 58.268 µM 1.4671161461797 0.0550405289974763 no 247 0.071172231285216 100 1379719 SGTC_711 k292-0785 179 µM 1.46317989301682 0.0555193619224721 no 248 0.0717090805859469 103 4146315 SGTC_1296 1068-0102 11.9 µM 1.46136160979588 0.0557416579502766 no 249 0.0719581151748521 79 767053 SGTC_1413 3910-0535 34.4 µM 1.45661456867001 0.0563253232376368 no 250 0.0726114019420498 113 2876951 SGTC_1377 2944-0135 198 µM 1.45606893094605 0.056392718870148 no 251 0.0726867826274868 87 1894137 SGTC_874 0599-0792 117 µM 1.45598435253623 0.0564031714442584 no 252 0.0726984726266894 126 765305 SGTC_3009 9080819 71.4286 µM 1.45407633540378 0.0566393786724851 no 253 0.0729625718336647 104 17027216 SGTC_2867 9039098 71.43 µM 1.44550873113294 0.0577096443838331 no 254 0.0741575211691079 112 6463460 SGTC_2437 5741531 144.16 µM 1.44318577238224 0.0580025521215672 no 255 0.0744840731671182 124 2262990 SGTC_2751 anetholtrithion 17.25 µM 1.44219614752661 0.0581276907796765 no 256 0.074623523548025 94 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_23 0213-0011 39.996 µM 1.43884042754608 0.0585536033796657 no 257 0.075097869602719 111 627608 SGTC_2141 5621638 7.665 µM 1.43784252342423 0.0586807302797766 no 258 0.0752393704369228 94 2856238 SGTC_1971 st069429 63.5 µM 1.43627213858917 0.0588812263551421 no 259 0.0754624594104067 78 1246522 YGL099W LSG1 SGTC_759 3486-0358 89.3 µM 1.43356303587035 0.0592283692748385 no 260 0.0758484991469377 114 875103 SGTC_1929 genistein trimethyl ether 50.5 µM 1.42858886089551 0.0598699339121868 no 261 0.0765612188101017 99 136420 SGTC_1232 0279-0259 161 µM 1.42832781640169 0.0599037529436248 no 262 0.0765987625152265 103 1560000 SGTC_1764 st044502 93.5 µM 1.42693962730858 0.0600838480702521 no 263 0.0767986486531968 103 8407 SGTC_3048 9093155 49.47 µM 1.42690397986867 0.0600884783270417 no 264 0.0768037867661502 89 25236002 SGTC_2407 paclitaxel 400 µM 1.42625157608344 0.0601732686085836 no 265 0.0768978684215437 107 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2678 equilin 100 µM 1.42399077375844 0.0604678208100879 no 266 0.0772245714358462 82 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_563 tetrahydrosecaminediol 614 µM 1.41805371046888 0.0612467127879394 no 267 0.0780875421468754 88 334274 A psychoactive constituent of the cannabis plant. SGTC_1197 1601-0112 267 µM 1.41327783082531 0.0618789388310642 no 268 0.0787870248655046 111 7350313 SGTC_717 1532-0246 73.2 µM 1.41296287556583 0.0619208106562514 no 269 0.0788333200292076 106 9561992 SGTC_2566 crystal violet carbinol 226 nM 1.4108148805224 0.0622069664456596 no 270 0.0791496028146024 146 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1172 0370-0043 85 µM 1.40778291626189 0.0626126389404082 no 271 0.0795976802710244 92 376585 SGTC_1200 1643-0193 18.4 µM 1.40576185872072 0.0628841969728684 no 272 0.0798974257007831 118 5403974 SGTC_644 1498-1197 63.3 µM 1.40471279515131 0.0630255149998278 no 273 0.0800533497064734 116 6741615 SGTC_397 arbidol 50 µM 1.40385343573324 0.0631414624307465 no 274 0.0801812490034041 99 131410 A RNA synthesis inhibitor. SGTC_3042 9091578 49.47 µM 1.39679451282053 0.0641001702087542 no 275 0.081237686423682 93 25236497 SGTC_1522 st012842 45.6 µM 1.39642915576318 0.0641500975283907 no 276 0.0812926501957756 110 3491067 YOR116C RPO31 SGTC_1590 st077108 57.8 µM 1.39344028158199 0.0645596735798616 no 277 0.0817433459240318 97 5489485 SGTC_1149 3909-7961 23.3 µM 1.39199235228985 0.0647588174717892 no 278 0.0819623569158499 103 735261 SGTC_1447 4239-0816 81.9 µM 1.39112347796147 0.0648785486728083 no 279 0.0820939932767173 132 1341554 SGTC_39 0986-0283 58.349 µM 1.38950788572035 0.0651016346700367 no 280 0.0823391823405058 98 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_352 k048-0007 5.11 µM 1.38835308010359 0.0652614583172923 no 281 0.0825147781622695 147 6811911 SGTC_1741 st038134 10.228 µM 1.38591092248145 0.0656004522971217 no 282 0.0828870525935766 102 1272587 SGTC_1169 aniline yellow 25.8 µM 1.3804762800876 0.0663597293420458 no 283 0.0837200240052145 108 6051 A DNA damaging agent. SGTC_1587 estradiol valerate 56.1 µM 1.37845705773623 0.0666435636261887 no 284 0.0840311087034127 124 13791 A steroid. SGTC_568 1193-0097 7.48 µM 1.37745575989355 0.0667846602351563 no 285 0.0841856918090421 135 3646150 SGTC_49 0717-0965 32.132 µM 1.37592177182713 0.0670012683671223 no 286 0.0844229269435591 107 5889349 YGL099W LSG1 SGTC_846 0335-0850 148 µM 1.37518374837137 0.0671056750338848 no 287 0.0845372426980767 107 6819598 SGTC_65 0798-0905 34.986 µM 1.37175928851621 0.0675917733921243 no 288 0.0850691923925819 125 3602145 SGTC_1614 st002383 48.6 µM 1.36969920158115 0.0678855084606452 no 289 0.0853904090218251 88 1947235 SGTC_1230 0170-0365 3.77 µM 1.36950670898107 0.0679130050719727 no 290 0.0854204695529335 134 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2413 inermin 26.06 µM 1.36792815645352 0.0681388180138442 no 291 0.0856672826693336 154 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3305 9127027 53.8275 µM 1.36395160292259 0.0687102354070493 no 292 0.0862913990983391 117 41905295 SGTC_598 3937-0236 20.2 µM 1.36045853286427 0.0692152202306273 no 293 0.0868424333002534 114 1379313 SGTC_734 2023-0417 80 µM 1.36029228481919 0.0692393254100351 no 294 0.0868687244339827 136 3935732 SGTC_756 0508-1999 28.3 µM 1.35799785699825 0.0695726675333638 no 295 0.0872321820776865 130 6753853 SGTC_1339 1486-1321 22.7 µM 1.35630999444863 0.0698186736709048 no 296 0.0875002784252038 118 3469382 SGTC_1140 3229-1848 2.98 µM 1.35104314549918 0.0705906223567222 no 297 0.0883408060684016 114 2849525 SGTC_1410 3909-8106 77.9 µM 1.34861633831871 0.0709485136174081 no 298 0.0887301150234614 137 1039210 SGTC_803 4488-1585 147 µM 1.34553545710936 0.0714048697260743 no 299 0.0892261894623401 110 747204 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.34324514903631 0.0717455794618352 no 300 0.089596303296043 131 616764 SGTC_1722 st034304 3.6505 µM 1.33897252689971 0.0723845124699302 no 301 0.0902898084127666 124 4036148 YLR033W RSC58 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.33876964893844 0.0724149591540816 no 302 0.0903228371561957 111 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1122 capsaicin 818.572 nM 1.33777562361067 0.0725642782257842 no 303 0.090484795207939 121 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1332 1480-0653 17.5 µM 1.33713656669124 0.0726603996347885 no 304 0.0905890315252432 118 5749438 SGTC_1433 4060-0023 7.6 µM 1.33589168025192 0.0728479246207667 no 305 0.0907923403460444 130 3840627 SGTC_2837 9008476 45.46 µM 1.33370435860508 0.0731783116131668 no 306 0.0911503828939801 101 2992805 SGTC_610 4215-0184 155 µM 1.33339416647207 0.0732252576829793 no 307 0.0912012428828674 123 5605015 SGTC_2259 7964009 200 µM 1.33000785316348 0.0737392595739473 no 308 0.0917578419291206 99 313134 SGTC_2749 bexarotene 57.39 µM 1.32889757629994 0.073908385324537 no 309 0.0919408817877194 115 82146 An retinoic acid receptor inhibitor. SGTC_297 0986-0032 24 µM 1.32883488897553 0.0739179431640149 no 310 0.0919512244571326 132 2847425 SGTC_1365 1672-3266 55.4 µM 1.32860262840091 0.0739533638075485 no 311 0.0919895522235987 141 6415873 SGTC_2215 7188065 200 µM 1.32805522126471 0.0740368968334971 no 312 0.0920799324440481 111 940217 SGTC_1649 st011737 51.3 µM 1.32527649881176 0.0744620353220589 no 313 0.0925397303743345 108 1761035 SGTC_3333 9141820 12.094 µM 1.3234143095235 0.0747479875530492 no 314 0.0928488178446187 121 1939433 SGTC_1892 st058411 7.36 µM 1.31964579884483 0.0753292314205513 no 315 0.0934766521102332 110 3934738 SGTC_1359 1582-0056 520 nM 1.31734040350945 0.075686503443803 no 316 0.093862273893963 115 3661189 SGTC_2094 5332512 191.667 µM 1.3164712986094 0.0758215250144837 no 317 0.0940079527832593 123 755774 SGTC_3018 9082602 49.47 µM 1.313617904645 0.076266109873121 no 318 0.0944874101562674 131 17332089 SGTC_3176 9106582 49.47 µM 1.31237118002429 0.0764609825978614 no 319 0.0946974630276342 62 17018027 SGTC_774 k060-0086 136 µM 1.31149771648601 0.0765977372286595 no 320 0.0948448323566362 121 5911235 SGTC_2219 9098279 200 µM 1.31003726907512 0.0768268089893284 no 321 0.0950916140057864 79 902349 SGTC_2585 alliin 100 µM 1.30919454241925 0.0769592277745975 no 322 0.0952342302236753 114 87310 A garlic compound which reacts with lipids. SGTC_518 1021-0119 62.6 µM 1.30214120648159 0.0780743386994843 no 323 0.0964340595469463 137 1097762 SGTC_2353 9059630 146.67 µM 1.30159514497785 0.0781611779423863 no 324 0.0965274101859822 115 4779114 SGTC_3136 9095672 49.47 µM 1.30090119240745 0.0782716417425195 no 325 0.0966461389619514 128 17217380 SGTC_1055 3448-0672 86 µM 1.29844449296717 0.0786636522551824 no 326 0.0970673192283244 129 748378 SGTC_431 k089-0097 107 µM 1.2979996975486 0.0787347861603623 no 327 0.0971437194510218 138 5499420 SGTC_3201 9113999 49.47 µM 1.29706474399261 0.0788844674981402 no 328 0.0973044554747264 114 16649224 SGTC_1644 st010134 20.9 µM 1.29282172531621 0.0795664633957434 no 329 0.098036362309486 128 3818134 SGTC_1127 asiatic acid 681.4 nM 1.285766889375 0.0807102751841893 no 330 0.0992622144971225 132 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1174 0739-0097 51.1 µM 1.28554043988813 0.0807471944123809 no 331 0.0993017472968226 138 728447 SGTC_2644 guaiazulene 100 µM 1.28001778404883 0.0816515341195808 no 332 0.100269440710749 102 3515 A coloring agent. SGTC_2485 5633444 17.78 µM 1.2766072947699 0.0822138060926036 no 333 0.100870462592897 130 5724239 SGTC_3183 9108214 49.47 µM 1.27292392994862 0.0828243361369219 no 334 0.101522518368649 69 4974831 SGTC_2493 resveratrol 26.09 µM 1.26778151106538 0.0836824065938109 no 335 0.102437993292848 89 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2397 5161689 200 µM 1.26714367991614 0.0837892997614754 no 336 0.102551959770966 114 2259942 SGTC_3205 9113483 49.47 µM 1.26265449608154 0.0845445382602991 no 337 0.10335668694792 121 17018033 SGTC_1305 1181-0477 144 µM 1.26225275167173 0.0846123739369409 no 338 0.103428926158729 141 6252086 SGTC_3303 9125618 40.5795 µM 1.26179858070888 0.0846891111396591 no 339 0.103510636517009 129 22695467 SGTC_2453 5731132 22.18 µM 1.26008204990674 0.0849796094290784 no 340 0.103819882449174 155 1362040 SGTC_2743 auranofin 4.32 µM 1.26005096029531 0.0849848777792115 no 341 0.103825489648656 96 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2415 st077333 57.7 µM 1.25976524688755 0.0850333053601656 no 342 0.103877030075742 172 2766255 SGTC_3193 9111931 49.47 µM 1.25264410003845 0.0862470105788928 no 343 0.105167628988553 126 17087244 SGTC_408 cantharidin 100 µM 1.25134331857972 0.0864701042339435 no 344 0.105404623709802 128 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_53 0973-0023 39.979 µM 1.24989174616645 0.0867195687050434 no 345 0.105669547468344 123 674768 SGTC_184 1494-0393 24.714 µM 1.24772268590347 0.0870933410253052 no 346 0.106066315235152 171 3090647 SGTC_1217 1183-1422 255 µM 1.24550822069441 0.0874761773801755 no 347 0.106472497809293 131 2849664 SGTC_3269 9137823 49.47 µM 1.24452264897292 0.0876469661646477 no 348 0.106653634451048 105 17682936 SGTC_87 0100-0052 35.5 µM 1.24131146258589 0.0882051554702265 no 349 0.107245355922012 156 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2796 7949634 45.45 µM 1.24112668450739 0.0882373552371615 no 350 0.107279476634444 145 2971588 SGTC_2015 5119600 184 µM 1.23808786305836 0.0887681633797839 no 351 0.107841741828791 154 2828786 SGTC_1910 st062352 60.4 µM 1.2370287709663 0.0889537186687645 no 352 0.108038200778233 118 2245730 SGTC_1758 st042942 75.2445 µM 1.23330679397214 0.0896081078261161 no 353 0.108730662042844 142 669317 SGTC_1271 0832-2808 169 µM 1.23225743619264 0.089793248703258 no 354 0.108926467037055 156 3663794 SGTC_658 3253-0951 102 µM 1.230008020798 0.0901910766085867 no 355 0.109347050655633 149 1184878 SGTC_2034 5197015 53.07 µM 1.22486071681459 0.0911063436515619 no 356 0.110313851787343 140 780676 SGTC_1060 3448-7350 82 µM 1.22061364171523 0.0918667088628252 no 357 0.111116169393548 143 570178 SGTC_2909 7941780 10.49 µM 1.21801075458154 0.0923350279049607 no 358 0.111609942952733 133 1243215 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.21678854187943 0.092555540592689 no 359 0.11184234032786 112 77254 SGTC_2014 4013930 200 µM 1.21450318553228 0.0929689114634732 no 360 0.112277817065504 141 64556 SGTC_127 0180-0333 59.125 µM 1.211350594324 0.0935413838166587 no 361 0.112880532905118 104 771601 SGTC_1428 4049-0204 61.7 µM 1.21011332475008 0.0937667668949191 no 362 0.113117705430571 159 X1428 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.2073699533414 0.094267933409102 no 363 0.113644850782449 150 5282309 SGTC_353 1988-1175 58.3 µM 1.20648808727441 0.0944294539698838 no 364 0.113814674822852 147 2788357 SGTC_1466 k213-0079 57.5 µM 1.20601079167186 0.0945169594032701 no 365 0.113906664707983 167 3657981 SGTC_1458 k015-0034 6.33 µM 1.20583781389151 0.0945486872002597 no 366 0.113940016046411 125 3598957 SGTC_2663 amphotericin b 100 µM 1.20561491526192 0.0945895831174989 no 367 0.113983002736153 156 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2924 9010168 62.78 µM 1.20496797910394 0.0947083523853769 no 368 0.114107831805228 131 2993929 SGTC_1074 carmofur 3.8 µM 1.20477603212846 0.0947436125481101 no 369 0.114144887511563 160 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3209 9113616 49.47 µM 1.20426444646339 0.0948376367632876 no 370 0.114243691899669 154 16649353 SGTC_2515 chrysin 20.77 µM 1.20424078769968 0.0948419866649368 no 371 0.114248262675189 117 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2277 7947813 106.88 µM 1.19629411795621 0.0963113923815827 no 372 0.115790901677628 137 1246798 SGTC_2517 totarol 10 µM 1.19349006835977 0.0968338579465923 no 373 0.11633874973752 125 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3143 9086658 49.47 µM 1.19327893749372 0.0968732810682911 no 374 0.116380074270445 166 25236626 SGTC_1139 k015-0024 46.9 µM 1.19287775880914 0.0969482230763819 no 375 0.116458625453262 137 2766652 SGTC_1949 st076024 69.1 µM 1.19261262362977 0.0969977748913525 no 376 0.116510559819271 161 2921930 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.19215804264311 0.0970827759940984 no 377 0.116599640827922 180 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1807 st050092 58.9 µM 1.18989094346365 0.0975075122362428 no 378 0.117044629258738 153 5008496 SGTC_281 1672-3440 14.9 µM 1.18884250238305 0.0977043956838037 no 379 0.117250824715824 150 6833000 SGTC_605 1315-0399 119 µM 1.18671010436955 0.0981057309321115 no 380 0.117670994015519 162 24020461 SGTC_1282 0886-0010 32.4 µM 1.18444798962605 0.0985327988059553 no 381 0.118117886525965 167 2836211 YNL267W PIK1 SGTC_3014 9081533 49.47 µM 1.18393984329792 0.0986289194066915 no 382 0.118218438355249 172 21367265 SGTC_2504 purpurogallin 52.29 µM 1.18339633728579 0.0987318045679068 no 383 0.118326054121783 133 5281571 An antioxidant. SGTC_1297 1068-0111 14.1 µM 1.18251459700703 0.0988988841895039 no 384 0.11850078853899 146 767057 SGTC_487 nimodipine 119 µM 1.18205235069042 0.098986557146169 no 385 0.118592464689697 110 4497 L-type voltage-gated calcium channels inhibitor SGTC_3308 9128332 17.569 µM 1.18139520607453 0.0991112937618682 no 386 0.118722880780749 147 17332805 YDL196W YDL196W SGTC_3151 9099821 49.47 µM 1.1800765182814 0.099361948644368 no 387 0.118984891478033 145 17174189 SGTC_3000 9075062 71.4286 µM 1.17958990967929 0.0994545596880729 no 388 0.11908167902824 135 17057871 SGTC_1683 st010134 710 nM 1.17771283710374 0.0998123940678841 no 389 0.119455553721117 137 3818134 SGTC_2820 7989630 71.43 µM 1.17698388483819 0.0999516105905764 no 390 0.119600969218562 98 2984098 SGTC_2492 derrusnin 100 µM 1.17298090394622 0.100718634625679 no 391 0.120401731793954 162 1715307 Part of coumarin class of compounds. SGTC_465 cgp-37157 41 µM 1.17190139985967 0.100926214901046 no 392 0.120618322493052 122 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2292 7671323 168.05 µM 1.17159192582273 0.100985781847358 no 393 0.120680465640204 185 937504 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.17115967091667 0.101069024301985 no 394 0.120767301208761 130 1241132 A phosphatase inhibitor. SGTC_2184 6075246 200 µM 1.16925452333964 0.101436508359232 no 395 0.121150549841573 144 2267320 SGTC_2694 st077685 81.9 µM 1.16617034988118 0.102033476316152 no 396 0.121772788939892 138 2838096 SGTC_2221 6807166 181.081 µM 1.16607993650671 0.102051015079409 no 397 0.12179106386205 121 674925 SGTC_2412 st077135 33.4 µM 1.16474833189795 0.1023095794001 no 398 0.122060439386542 151 13258915 SGTC_3340 9146634 11.102 µM 1.15680581698275 0.103861718106254 no 399 0.123675852362601 120 4907387 SGTC_3060 1327-0027 12.5 µM 1.15367458212606 0.104478299585783 no 400 0.124316804235475 149 16000455 YPR107C YTH1 SGTC_2993 9054257 71.4286 µM 1.15194734375675 0.104819548441015 no 401 0.124671355888922 166 6470217 YGL055W OLE1 SGTC_280 3448-3607 3.04 µM 1.14966129937102 0.105272440040863 no 402 0.125141699965482 119 626179 SGTC_1254 0550-0035 264 µM 1.14922017387755 0.105359994770434 no 403 0.12523260213487 159 15121435 SGTC_2693 st077581 40.7 µM 1.14771752420303 0.105658636483288 no 404 0.125542597214946 162 25238761 SGTC_3262 9137218 49.47 µM 1.13848413958695 0.107507152097196 no 405 0.12745918896579 106 17650664 SGTC_2167 5876490 200 µM 1.13415605638075 0.108381608452639 no 406 0.128364546613971 154 686534 SGTC_1618 st003135 44.5 µM 1.13352824003624 0.108508877824317 no 407 0.128496244445266 162 1270615 SGTC_981 1488-1094 54.9 µM 1.13118813469736 0.108984205347114 no 408 0.128987957450156 151 3449522 SGTC_404 fumagillin 50 µM 1.12905232655041 0.109419340303665 no 409 0.129437880257514 162 12015870 A methionine aminopeptidase binder. SGTC_59 0330-0160 1.33 µM 1.12608145704419 0.110026677931438 no 410 0.130065521021456 149 4293482 SGTC_491 tetrandrine 80.3 µM 1.12574638927631 0.110095327628126 no 411 0.130136441071751 141 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1734 st037168 69.4 µM 1.12451238712624 0.110348418677389 no 412 0.130397859255161 148 708907 SGTC_669 0108-0021 26.2 µM 1.12076118939601 0.111120341889455 no 413 0.131194764197976 152 17201 SGTC_529 4076-0302 30.3 µM 1.1187577691272 0.111534187158539 no 414 0.131621746257373 154 5816522 SGTC_1977 st070720 65.3 µM 1.11813487366523 0.111663082762447 no 415 0.131754697051506 124 682188 SGTC_188 3229-0966 278.469 µM 1.11471069312245 0.112373550817444 no 416 0.132487208621527 197 5722370 SGTC_101 0490-5701 117.494 µM 1.11374271729654 0.112574976146232 no 417 0.1326947888721 131 4661669 SGTC_1138 3761-0006 1.03 µM 1.11348312183735 0.112629038987398 no 418 0.13275049661195 134 12061087 SGTC_379 3970-0972 5.9 µM 1.10610275518711 0.114173823594421 no 419 0.134341023167328 153 2898042 YBL034C STU1 SGTC_2045 5106652 78.05 µM 1.10604664394852 0.114185625754699 no 420 0.134353165488529 135 673349 SGTC_798 1287-0182 476 µM 1.10409061781456 0.114597589819974 no 421 0.134776915367891 163 1649755 SGTC_1129 3453-1384 223 µM 1.10380396775434 0.114658050734424 no 422 0.1348390916633 170 1084452 SGTC_2108 5365811 200 µM 1.09936958781566 0.115596253583008 no 423 0.135803445233367 153 780283 SGTC_1460 k062-0059 9.15 µM 1.09924693524677 0.115622281055243 no 424 0.135830185695535 155 1373085 SGTC_629 3448-6466 76.7 µM 1.09878864135069 0.115719570089851 no 425 0.13593013389955 175 573744 SGTC_2381 9035592 200 µM 1.09716145838431 0.116065466702488 no 426 0.136285409007593 150 4749657 SGTC_2654 protoveratrine a 100 µM 1.09491562537116 0.11654407670305 no 427 0.13677680143535 177 5702278 A heart drug and vasodilator. SGTC_2254 7938975 95.19 µM 1.09318421230272 0.116914012865025 no 428 0.137156463683033 154 2969277 SGTC_1624 st003710 6.25 µM 1.09030822795471 0.117530337685353 no 429 0.137788695992516 153 24207033 SGTC_1077 5-fluorocytosine 377 nM 1.08879547510156 0.11785544292471 no 430 0.138122043735263 185 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2545 solidagenone 89.61 µM 1.08388752959298 0.118914587303315 no 431 0.139207334722401 119 6708572 An anti ulcer agent SGTC_1398 3558-0053 112 µM 1.08187305655825 0.119351254557714 no 432 0.13965446926987 135 4532369 SGTC_863 0466-0191 129 µM 1.08174536452377 0.119378971807958 no 433 0.139682844803081 188 765160 YPR165W RHO1 SGTC_1471 k673-0312 37 µM 1.0770121254117 0.120409590289406 no 434 0.140737424349371 174 24099884 SGTC_1270 0831-1170 17.3 µM 1.07605369665047 0.120619039852678 no 435 0.140951621135783 173 6764716 SGTC_841 0251-0215 91.2 µM 1.07545749704545 0.120749459260656 no 436 0.14108497576113 172 3888614 SGTC_2570 licareol 100 µM 1.07179300638284 0.12155325125777 no 437 0.141906507517218 158 443158 SGTC_2605 digitonin 300 nM 1.07158926966823 0.121598050225051 no 438 0.141952277526846 193 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_651 3253-0966 34.4 µM 1.067560420584 0.122486324406429 no 439 0.142859422628079 169 781462 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.06407578661415 0.123258274929799 no 440 0.143647184387286 183 689007 SGTC_2055 5235184 200 µM 1.06382496591259 0.123313970438518 no 441 0.143703999628049 166 2836034 SGTC_2285 7945142 200 µM 1.06284809491656 0.123531055713616 no 442 0.14392542238154 167 2970608 SGTC_2572 astragaloside iv 100 µM 1.06122285094188 0.123892818575587 no 443 0.144294318480498 163 45006101 An anti-inflammatory agent. SGTC_1505 k297-0037 20.6 µM 1.0604149951666 0.124072914728918 no 444 0.144477921628329 156 4089396 SGTC_400 oxethazaine 37.5 µM 1.05932552905007 0.124316080547326 no 445 0.144725776168006 168 4621 A local anesthetic. SGTC_2843 9000894 45.46 µM 1.05791622447341 0.124631127597496 no 446 0.145046818840397 111 2242070 SGTC_2183 6420625 130.508 µM 1.0575997544844 0.124701950456641 no 447 0.145118977254698 193 2897619 SGTC_456 gingerol 170 µM 1.05701981910901 0.124831807258047 no 448 0.145251271179662 184 442793 A herb. SGTC_2711 st079103 59.1 µM 1.05216782010664 0.125921950012782 no 449 0.146361280375814 158 54693780 SGTC_1260 0700-1617 7.75 µM 1.0515207358841 0.126067836519581 no 450 0.146509745449427 173 2853078 SGTC_1634 st006576 41 µM 1.05134577819424 0.126107301329765 no 451 0.146549904574632 176 3915356 SGTC_3182 9108849 49.47 µM 1.05053809536427 0.126289600165912 no 452 0.14673539280589 172 17133045 SGTC_1748 st037455 53.6035 µM 1.04584879756991 0.127351630839281 no 453 0.147815423708072 169 580690 SGTC_2630 antimycin a 100 µM 1.04349032057694 0.127888119312835 no 454 0.148360630736863 183 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1728 st035614 33.7865 µM 1.04311774448959 0.127973013525686 no 455 0.148446881688856 187 15945546 SGTC_822 1487-0950 154 µM 1.042440570105 0.128127412943502 no 456 0.148603732657009 173 1958375 SGTC_2298 7976326 193.81 µM 1.04148974268552 0.128344425036532 no 457 0.148824155639882 127 2235818 SGTC_1757 st041620 31.8375 µM 1.04096145122343 0.128465109859103 no 458 0.148946719749736 155 5289815 SGTC_1906 st060206 94.7 µM 1.03853850583607 0.129019625324067 no 459 0.149509709070211 183 5133468 SGTC_1813 st051246 8.6015 µM 1.03828537787316 0.129077651820768 no 460 0.149568607058161 162 5291959 SGTC_1874 staurosporine 7.6 µM 1.03737162285532 0.129287269555131 no 461 0.149781349017739 187 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2355 9061122 103.12 µM 1.0355617592991 0.129703153055465 no 462 0.150203320027398 192 5302957 SGTC_339 3091-4833 71.4 µM 1.03474634154272 0.129890828055047 no 463 0.150393693936543 196 3240077 SGTC_2953 9074162 66.49 µM 1.03470863140169 0.129899511895457 no 464 0.150402501933309 165 16451992 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.03321269941997 0.130244317351923 no 465 0.150752185564618 160 4330530 SGTC_2791 5663188 71.43 µM 1.0328929083637 0.130318109803202 no 466 0.150827008933368 194 54690634 SGTC_2794 7785382 27.27 µM 1.03244757208133 0.130420920252403 no 467 0.150931248027475 179 2205081 SGTC_3024 9090631 49.47 µM 1.03124352101887 0.130699168625093 no 468 0.151213318203289 153 25236383 SGTC_1843 st055809 45.5 µM 1.0284942758079 0.131336038820695 no 469 0.15185869104321 179 16413835 SGTC_2823 7987624 58.44 µM 1.02439521810926 0.132289570525206 no 470 0.15282431983969 185 2239440 SGTC_862 0452-0056 10.2 µM 1.0234554046305 0.132508862762254 no 471 0.15304628742868 167 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1281 0884-0031 11.8 µM 1.0213085060172 0.133010750525661 no 472 0.153554148850398 186 1548255 SGTC_336 4111-0029 111 µM 1.01860809007739 0.13364389193621 no 473 0.154194530999466 165 3131175 SGTC_1251 0490-5699 265 µM 1.01374794482782 0.134788619048385 no 474 0.155351520000286 187 3883818 SGTC_926 2268-1401 59.4 µM 1.01319482095455 0.134919323384562 no 475 0.155483556886413 196 2931578 SGTC_1472 k841-0093 193 µM 1.01250452770608 0.135082563053376 no 476 0.15564844147087 183 X1472 SGTC_433 pimozide 108 µM 1.00748808993726 0.136272912054979 no 477 0.156850139150413 164 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_451 chloral hydrate 100 µM 1.00619272412884 0.136581451464945 no 478 0.157161435725968 197 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3270 9137563 49.47 µM 1.00556714328916 0.136730627678514 no 479 0.157311917926475 168 17015724 SGTC_1399 3562-5772 25 µM 1.00510446959548 0.136841028632129 no 480 0.157423274058875 165 23847490 SGTC_2662 daunorubicin 22.37 µM 1.00075509993013 0.137881832725762 no 481 0.158472610837211 184 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1933 st074711 15.9 µM 0.99797768824585 0.138549285674022 no 482 0.159145088970735 209 17250958 SGTC_3101 9120531 49.47 µM 0.996924738487897 0.138802899571601 no 483 0.159400521372627 181 24824904 SGTC_1526 st051518 75 µM 0.99386525695595 0.139541600642624 no 484 0.160144235414815 168 673993 SGTC_1860 st056228 74.6 µM 0.993334807632251 0.13966994723416 no 485 0.160273410067119 200 688679 SGTC_445 e6 berbamine 66 µM 0.99279820350886 0.139799864674986 no 486 0.160404152803334 207 6610268 A calcium/calmodulin antagonist. SGTC_2252 omeprazole 400 µM 0.992674925771262 0.13982972309805 no 487 0.160434199068397 157 4594 A proton pump inhibitor. SGTC_3185 9108267 49.47 µM 0.992268744721317 0.139928132645748 no 488 0.160533222874889 185 4910486 SGTC_2443 5493264 126.67 µM 0.990958712876643 0.140245847828144 no 489 0.160852870525351 194 5340055 SGTC_2918 7977171 22.06 µM 0.989879480001725 0.140507956361962 no 490 0.161116515192644 185 2236483 SGTC_1276 0871-0068 94.2 µM 0.989258009423723 0.140659040975126 no 491 0.16126846144961 206 3414906 SGTC_84 0443-0269 128.823 µM 0.988743994708454 0.140784085462989 no 492 0.161394205924339 178 6150058 SGTC_1701 st028638 40.4 µM 0.98852257186403 0.14083797429057 no 493 0.161448392748324 167 3490878 SGTC_1663 st014140 55.4 µM 0.984850025784266 0.141733822048976 no 494 0.162348871871722 181 4207120 SGTC_2278 7948257 134.34 µM 0.984817308100105 0.141741820212023 no 495 0.162356908651862 180 1247028 SGTC_2521 angolensin 13.4 µM 0.983638418705343 0.142030215401665 no 496 0.16264666410576 173 821428 A flavenoid. SGTC_890 0929-0006 47.2 µM 0.983089400325562 0.142164658861941 no 497 0.162781720320428 173 1378169 SGTC_2623 humulene 100 µM 0.981708182503515 0.142503271872859 no 498 0.163121816561685 165 6187145 An anti-inflammatory. SGTC_1020 4335-0961 93.3 µM 0.980525550983517 0.142793633517022 no 499 0.163413381760585 199 669075 SGTC_935 2996-0153 430 µM 0.980280555244517 0.142853835246372 no 500 0.163473825149827 197 23738523 SGTC_1468 k284-1086 134 µM 0.973768720623837 0.144460248381797 no 501 0.16508569362112 195 15996457 SGTC_2808 7946468 45.46 µM 0.970467688724928 0.145279216067992 no 502 0.165906711540184 207 2970879 SGTC_832 4083-0019 164 µM 0.969585071306259 0.145498716779935 no 503 0.166126678578257 213 1990758 SGTC_1760 st045453 10.4495 µM 0.967269994216775 0.146075519366205 no 504 0.166704539821218 210 3323419 YIL048W NEO1 SGTC_1970 st070122 35.8 µM 0.966862524483862 0.146177199408701 no 505 0.166806381510958 209 102928 SGTC_216 k038-0035 28.382 µM 0.965662968629574 0.146476812626435 no 506 0.167106427650398 218 4444231 YPR107C YTH1 SGTC_826 1683-5028 118 µM 0.965643141009689 0.146481768434324 no 507 0.167111390075063 176 722377 SGTC_2076 5212012 200 µM 0.964504366739403 0.146766587865365 no 508 0.167396560090934 182 604802 SGTC_3179 9107801 49.47 µM 0.963998560293688 0.146893214468017 no 509 0.167523323838843 164 4818259 SGTC_2851 9015922 71.43 µM 0.963112960575581 0.147115097206559 no 510 0.167745419162557 213 2996893 SGTC_1141 3253-0389 52.6 µM 0.962281697560534 0.147323570494388 no 511 0.1679540600725 206 5402031 SGTC_1565 sinapyl alcohol 95.1 µM 0.961455034671238 0.147531086370474 no 512 0.168161711961875 200 5280507 A phenol propionate derived from cinnamic acid. SGTC_1793 st048256 72.231 µM 0.957230141750937 0.148594711301741 no 513 0.169225553258993 182 672022 SGTC_3334 9142812 21.919 µM 0.957144927587145 0.148616216744307 no 514 0.169247054811458 176 45283678 SGTC_813 k007-0158 173 µM 0.956334897894289 0.148820747302662 no 515 0.169451532064864 192 6523916 SGTC_1252 0493-0875 34.8 µM 0.95571253220085 0.148978020878752 no 516 0.169608744604437 160 3960963 SGTC_1809 st050081 57.6 µM 0.955682347285963 0.148985651514654 no 517 0.169616371836133 215 5036894 SGTC_3125 9127534 49.47 µM 0.954826712176934 0.149202061540805 no 518 0.16983266827449 175 1639235 SGTC_1051 3253-3903 78 µM 0.954272097076091 0.149342448681872 no 519 0.169972964143666 222 5509239 SGTC_599 1935-0052 86.5 µM 0.953847821585056 0.149449903080409 no 520 0.170080339344464 170 9557311 SGTC_716 1683-5115 658 µM 0.953672394238554 0.149494347874058 no 521 0.170124749015956 203 723597 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.951179757228773 0.150126814526936 no 522 0.1707565662698 189 3256 An antibiotic and ribosome inhibitor. SGTC_1578 josamycin 24.2 µM 0.950727041884958 0.150241874902526 no 523 0.170871478523956 195 5282165 A P450 substrate. SGTC_3300 9124615 50.48 µM 0.950325269719171 0.150344036969085 no 524 0.170973501358458 180 24824903 SGTC_2073 5212005 126 µM 0.949673126651852 0.150509961524515 no 525 0.171139184336742 203 691789 SGTC_135 0933-0004 26.348 µM 0.949582880794809 0.150532932353884 no 526 0.171162120216473 194 21230617 YGL099W LSG1 SGTC_314 1671-0008 2.74 µM 0.946875673736405 0.151223100056594 no 527 0.17185106755169 212 3913060 SGTC_625 k213-0058 121 µM 0.945664038918824 0.151532671599892 no 528 0.172159984960419 211 3655420 SGTC_2955 9076254 12.21 µM 0.943191282567616 0.152165764947908 no 529 0.172791535756143 180 16459619 SGTC_3271 9137798 49.47 µM 0.942181985064523 0.152424676765084 no 530 0.173049737761128 168 6498326 SGTC_2564 betulinic acid 100 µM 0.94208498278385 0.15244957583698 no 531 0.173074566162296 186 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1605 st000082 49.1 µM 0.938174318117137 0.153455634490217 no 532 0.174077417082448 203 1114022 SGTC_1887 st057648 70.8 µM 0.93550635523507 0.154144513146257 no 533 0.174763704843809 218 688672 SGTC_1684 st024538 14.6195 µM 0.93474764220169 0.154340788874201 no 534 0.174959184015031 195 6732859 SGTC_2373 9071805 200 µM 0.934713126864999 0.154349721768272 no 535 0.174968080042167 205 10149009 SGTC_1944 st076371 56.9 µM 0.932527054197596 0.154916194459936 no 536 0.175532105909707 210 24208455 SGTC_2288 7946289 167.31 µM 0.932121246333075 0.155021501568136 no 537 0.175636934559751 200 1246052 SGTC_3012 9080433 71.4286 µM 0.927792014378828 0.156147878432998 no 538 0.176757733580761 218 17688859 SGTC_454 lyso-paf C-16 6.67 µM 0.927280612254507 0.156281289959258 no 539 0.176890428927645 216 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3058 9093861 49.47 µM 0.927255445098367 0.156287857354285 no 540 0.176896960765065 203 17217477 SGTC_426 0988-0037 14.6 µM 0.926988109824403 0.15635762998814 no 541 0.176966353879686 216 5383008 SGTC_3167 9103034 49.47 µM 0.926363400476087 0.156520754725427 no 542 0.177128578835119 187 5127859 SGTC_83 0170-0301 39.027 µM 0.926118577452919 0.15658471371179 no 543 0.177192180260181 182 3089716 SGTC_1029 k015-0030 64.7 µM 0.925186093518761 0.156828478773093 no 544 0.177434557962079 204 2208316 SGTC_1330 1469-0054 61.8 µM 0.924216132683035 0.157082305675548 no 545 0.177686898895101 201 7102664 SGTC_1355 1499-0035 1.68 µM 0.923340005129794 0.15731180967836 no 546 0.17791502308903 200 1548538 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.923257665925144 0.157333389983956 no 547 0.177936471883756 229 6708760 SGTC_2745 rifampicin 24.3 µM 0.919601905180247 0.158293490640422 no 548 0.178890415384868 143 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2681 menadione 3.18 µM 0.919498998802209 0.158320572123278 no 549 0.178917314531803 226 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2839 9003951 25.97 µM 0.919221355340125 0.158393653668735 no 550 0.178989901665098 187 2990634 SGTC_289 k017-0060 526 µM 0.919020880205707 0.158446436658841 no 551 0.17904232542245 207 5512909 SGTC_164 4100-3994 89.624 µM 0.917502417229828 0.158846606571104 no 552 0.179439713419567 223 4615967 SGTC_1940 st075990 51.1 µM 0.91405289936341 0.159758138839612 no 553 0.180344525049645 215 1084979 SGTC_2360 9040895 200 µM 0.913469475061882 0.159912645924456 no 554 0.180497840324684 199 4914414 SGTC_2708 st078559 56 µM 0.911863334650451 0.160338501576549 no 555 0.180920332440374 186 17250902 SGTC_2489 cantharidin 73.42 µM 0.911630164600512 0.160400386353939 no 556 0.180981718846628 192 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1118 chelidonine 707.474 nM 0.910762659541656 0.160630764610287 no 557 0.18121022047899 200 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2220 6782180 200 µM 0.910469109996338 0.160708769763282 no 558 0.18128758259898 183 833803 SGTC_2764 methyldopa 94.69 µM 0.910124484609465 0.160800378902839 no 559 0.181378431648099 198 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3347 9188721 44.724 µM 0.91004198805701 0.160822313389294 no 560 0.181400183354774 234 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2121 5257820 149.641 µM 0.907360801398275 0.161536260537286 no 561 0.182108015555389 195 791256 SGTC_1919 st067113 52.3 µM 0.906143763743673 0.16186101449372 no 562 0.18242988198283 219 1268243 SGTC_163 TUB2.036 7.546 µM 0.905988202697874 0.16190255499598 no 563 0.18247104836332 237 15992207 YJR013W GPI14 SGTC_2690 usnic acid 100 µM 0.904722759278853 0.162240732814254 no 564 0.182806140339497 198 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3332 9141069 11.198 µM 0.904484405539424 0.162304482035871 no 565 0.182869299854852 204 17332883 SGTC_2426 5582046 32.21 µM 0.904317844608962 0.162349039492101 no 566 0.182913443631607 195 2251934 SGTC_2032 5185112 25.99 µM 0.904048107728537 0.162421214892755 no 567 0.182984946316929 190 5718189 SGTC_311 1315-0136 58 µM 0.902383526008874 0.162867080769781 no 568 0.183426584603576 190 6759207 SGTC_3233 9132340 49.47 µM 0.90108019925677 0.163216737842887 no 569 0.183772839982537 236 17682950 SGTC_3211 9128781 49.47 µM 0.900722841726377 0.163312695023616 no 570 0.183867850391849 196 17194361 SGTC_2391 6285546 200 µM 0.90043888062075 0.16338897001877 no 571 0.183943368751371 203 846083 SGTC_1867 st057372 64 µM 0.895739603183723 0.164654605738725 no 572 0.185195926808241 193 688837 SGTC_3152 9099253 49.47 µM 0.894359958466885 0.165027382406712 no 573 0.185564664559206 228 25236131 SGTC_2991 9074669 71.4286 µM 0.894213856350379 0.165066890817654 no 574 0.18560373994446 232 17333109 SGTC_1191 1487-1166 10.6 µM 0.894025129926706 0.16511793460409 no 575 0.185654222866675 208 3955771 SGTC_2646 retinol 96.75 µM 0.893322433893059 0.165308078731404 no 576 0.185842263760994 219 445354 A vitamin A analog and teratogen. SGTC_3261 9137475 49.47 µM 0.890309037299425 0.166125086510861 no 577 0.186649984916342 144 17027690 SGTC_982 1491-0518 27.5 µM 0.888343113348039 0.166659501705362 no 578 0.187178107602602 202 3091256 SGTC_256 clotrimazole 625 nM 0.886031812806094 0.167289221117816 no 579 0.187800192312085 201 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2340 7987427 183.45 µM 0.883104610479059 0.168088942476095 no 580 0.188589876684689 199 2239331 SGTC_2784 7567673 72.73 µM 0.882483224499968 0.168259023205051 no 581 0.188757773793823 214 3471247 SGTC_3259 9138485 49.47 µM 0.880643952217842 0.168763102428227 no 582 0.189255280745018 192 17646153 SGTC_1680 diphenhydramine 100 µM 0.87720028479057 0.169709495882143 no 583 0.190188930715678 215 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3344 9148862 3.898 µM 0.876053063683223 0.17002553119934 no 584 0.190500593617177 221 4905352 SGTC_1307 1187-1599 12.2 µM 0.875323279642653 0.170226767552878 no 585 0.190699015449384 228 1538471 SGTC_3278 9139605 49.47 µM 0.874221484952749 0.170530874015142 no 586 0.190998823896185 224 7958859 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.873918136171462 0.170614662377703 no 587 0.191081418610397 208 279621 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.873888000657547 0.17062298758627 no 588 0.191089624995487 229 688801 SGTC_1085 doxorubicin 7.67 µM 0.87347775256272 0.170736348204782 no 589 0.191201363645977 229 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3133 9127736 49.47 µM 0.873059265886728 0.170852034980892 no 590 0.191315387488601 200 27243420 SGTC_1808 st050063 61.5 µM 0.873014902145708 0.170864301867168 no 591 0.19132747759039 222 4011993 SGTC_867 0518-0118 155 µM 0.871794103412953 0.171202082414909 no 592 0.191660355993081 232 6848158 SGTC_2229 7354935 190 µM 0.871418421291986 0.171306115066664 no 593 0.191762865555893 236 318112 SGTC_1321 1326-2144 215 µM 0.870475420665986 0.171567425681786 no 594 0.192020322921191 230 3513030 SGTC_2505 galangin 7.89 µM 0.870454525051957 0.171573218853229 no 595 0.192026030221517 229 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2185 6113692 200 µM 0.866239608917251 0.172744331516077 no 596 0.193179388195313 219 874150 SGTC_1509 1326-1131 80 µM 0.862884757972043 0.173680108465152 no 597 0.194100415870261 201 768313 SGTC_1500 4488-1866 171 µM 0.862742923061595 0.173719741757516 no 598 0.194139413520096 231 2900003 SGTC_3320 9137005 35.139 µM 0.862046566660402 0.173914409867688 no 599 0.19433094663426 228 4908713 SGTC_1043 0916-0009 19.3 µM 0.861597908331076 0.174039906834625 no 600 0.194454411214962 225 3101130 SGTC_748 act1.228 77.9 µM 0.861522681588477 0.174060954601554 no 601 0.194475117249538 201 4421505 YNR035C ARC35 SGTC_1000 4048-0884 8.67 µM 0.859560552309887 0.174610512207259 no 602 0.195015663939958 217 13040088 SGTC_134 0269-0018 6.916 µM 0.858405748054544 0.174934466863232 no 603 0.195334227354451 219 4378915 SGTC_3346 9158254 43.5805 µM 0.856227288215403 0.17554662293312 no 604 0.195936035692059 237 17639500 SGTC_1651 st011928 86.1 µM 0.855594114081951 0.175724801774198 no 605 0.196111163383778 204 720198 SGTC_958 1222-0007 33 µM 0.854919854653375 0.175914668173713 no 606 0.196297759066718 236 7312461 SGTC_761 k216-0224 480 µM 0.85223019116269 0.176673349364185 no 607 0.197043171445264 233 1340404 SGTC_1958 st076513 41.9 µM 0.850666192073534 0.177115460954151 no 608 0.197477404232309 226 732122 YGL099W LSG1 SGTC_1790 st045711 43.5 µM 0.848598855645294 0.177700927497771 no 609 0.198052271981256 180 585119 SGTC_2819 7996655 46.38 µM 0.848531734946977 0.17771995642097 no 610 0.198070953269658 196 6456960 SGTC_694 1315-0438 43.2 µM 0.847031476593725 0.178145619721257 no 611 0.198488788522399 218 6793154 SGTC_2460 5552655 174.22 µM 0.845128140510382 0.178686570936491 no 612 0.199019649068394 227 5401989 SGTC_2491 paeonol 100 µM 0.845057466791155 0.178706677160224 no 613 0.199039377174498 225 11092 Increases levels of cortical cytochrome oxidase. SGTC_753 1322-0200 289 µM 0.844845111684941 0.178767099407498 no 614 0.199098661801326 212 5403907 SGTC_3166 9102297 49.47 µM 0.844672446935598 0.178816237877683 no 615 0.19914687364056 226 25237072 SGTC_2919 7978188 46.38 µM 0.844654707895185 0.178821286693162 no 616 0.199151827173618 206 2980291 SGTC_1151 3909-8316 15.3 µM 0.841910506538153 0.179603410883595 no 617 0.199919024443743 232 800431 SGTC_1712 st032288 53.4 µM 0.841640588891932 0.179680456003955 no 618 0.199994581291853 235 2883011 SGTC_1794 st048918 76.9 µM 0.840587983794421 0.17998110929024 no 619 0.20028939635278 189 672303 SGTC_2060 5238662 140 µM 0.840071166574948 0.180128842220726 no 620 0.200434242747967 237 790130 SGTC_1753 st043925 64 µM 0.839159693824536 0.180389573440399 no 621 0.200689851028803 219 670181 SGTC_1066 ketoconazole 628 nM 0.836940394757722 0.181025404278313 no 622 0.201313036484809 231 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3253 9135987 49.47 µM 0.834408665354251 0.181752459030436 no 623 0.202025367942127 224 4182430 SGTC_1980 st071811 45.7 µM 0.832257323693795 0.182371708741892 no 624 0.202631856839774 230 4974850 SGTC_2049 5262831 67.185 µM 0.832072624094258 0.182424934695809 no 625 0.202683976535458 213 763417 SGTC_1408 3909-7976 48.8 µM 0.830769316778877 0.182800792110418 no 626 0.203051979660978 246 24152374 SGTC_1660 st012960 28.1 µM 0.826551479977813 0.184020473433481 no 627 0.204245663987491 219 24207266 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.82620290125506 0.184121498895071 no 628 0.204344501373052 203 521171 SGTC_714 4296-0578 26.1 µM 0.825591612072084 0.184298746724682 no 629 0.204517897454253 239 1589775 SGTC_2960 9079389 5.97 µM 0.821541182666842 0.185475879571655 no 630 0.205669038130204 200 16457355 SGTC_2549 cedrol 20.94 µM 0.821350818120798 0.185531317751741 no 631 0.205723234590482 237 6708665 A sedative which affects the nervous system. SGTC_423 5-fluorouracil 457 µM 0.818123747813644 0.186472673072832 no 632 0.206643264975679 232 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3114 9122766 49.47 µM 0.817132867149716 0.186762311361662 no 633 0.20692625100664 194 17176985 SGTC_2322 7413319 38.22 µM 0.816205162038758 0.187033735442664 no 634 0.207191402471728 231 1840400 SGTC_640 3381-0960 37.1 µM 0.81490895604978 0.187413382399149 no 635 0.207562213135266 239 1745025 SGTC_608 k048-0125 159 µM 0.813573555883099 0.187805006739763 no 636 0.207944646071021 232 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2628 lathosterol 100 µM 0.812640238278821 0.188079014700989 no 637 0.208212177110824 219 6710616 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.811645051131604 0.188371458305974 no 638 0.208497666374257 246 688788 SGTC_3017 9080681 49.47 µM 0.807751512045004 0.189518298575102 no 639 0.209616821591719 238 16451914 SGTC_1973 st070275 50.2 µM 0.804965283396488 0.19034161236179 no 640 0.210419856867022 218 17118334 SGTC_497 capsazepine 133 µM 0.804649733566411 0.190434993726489 no 641 0.210510917038407 232 2733484 A calcium channel blocker. SGTC_2787 5284540 71.43 µM 0.804042953198675 0.190614638638884 no 642 0.210686084393981 247 736958 SGTC_2129 girgensonine 121.053 µM 0.802238804765256 0.191149393521062 no 643 0.211207416751314 253 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1442 4112-3290 3 µM 0.802051387678888 0.191204997185819 no 644 0.21126161668203 240 704353 SGTC_2328 6201408 200 µM 0.801945952789181 0.19123628239636 no 645 0.211292111419791 252 2890418 SGTC_655 k060-0012 42 µM 0.801510948400163 0.191365392428972 no 646 0.211417954197327 248 5994525 SGTC_1389 3405-0187 19 µM 0.801037282270424 0.191506038067489 no 647 0.211555031369171 241 799890 SGTC_1697 st025554 27.742 µM 0.800799868277466 0.191576557201882 no 648 0.211623757645596 231 1269519 SGTC_182 3448-4371 550.524 µM 0.800515240124832 0.191661121332646 no 649 0.211706168636008 208 3491403 SGTC_213 1246-0773 967 nM 0.79947749451785 0.191969633164787 no 650 0.212006795641071 229 6251622 SGTC_3352 9151559 45.5865 µM 0.799062104919461 0.192093209647463 no 651 0.212127200781791 216 17159339 SGTC_570 0987-0065 62.6 µM 0.797440665743837 0.192576045940793 no 652 0.212597574819834 228 3104428 SGTC_1107 amlodipine 47 µM 0.794857883513909 0.193346683686257 no 653 0.21334808784921 212 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2021 4019055 173 µM 0.794746118496648 0.193380073999483 no 654 0.213380599709778 258 44827708 YER133W GLC7 SGTC_2213 7173844 200 µM 0.794007516888388 0.193600823071016 no 655 0.21359552766372 248 892728 SGTC_2148 5546263 113.568 µM 0.791704867839212 0.194290011571006 no 656 0.214266391650074 231 792097 SGTC_1383 3049-0032 20.7 µM 0.789042999854866 0.195088574245547 no 657 0.215043437442396 251 712864 SGTC_909 3448-9333 149 µM 0.787838503688088 0.195450578834968 no 658 0.215395587954013 224 3344074 SGTC_424 splitomicin 100 mM 0.787696509534675 0.195493281251086 no 659 0.215437123871222 249 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2370 9071495 200 µM 0.78740993753155 0.195579480342856 no 660 0.215520965634342 246 21791103 SGTC_389 tpck 16.7 µM 0.785036411455278 0.196294309147597 no 661 0.216216110220426 229 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1931 st074438 57.1 µM 0.784429011160406 0.196477492560213 no 662 0.21639421050442 279 2787313 SGTC_1001 4048-4355 44.4 µM 0.784019625694791 0.196601015897058 no 663 0.216514297295964 248 21824233 SGTC_2235 salicylic acid 500 µM 0.780536516450229 0.197653871686903 no 664 0.217537571137944 239 338 A COX inhibitor and kinase inhibitor. SGTC_2770 toltrazuril 17.5 µM 0.780082449618874 0.197791375246334 no 665 0.217671173028466 223 68591 Kills coccidiodes. SGTC_1295 1013-0063 9.78 µM 0.779978558340378 0.197822844422447 no 666 0.217701748026776 243 6826038 SGTC_2394 5221648 200 µM 0.776848800927608 0.198772280865223 no 667 0.218623990480758 248 788586 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.776069787030495 0.199009027153787 no 668 0.218853890800958 236 88881 An O-methylated flavonoid and antioxidant. SGTC_782 0083-0095 30.5 µM 0.775670449161851 0.19913045381153 no 669 0.218971796140024 248 3591729 An indicator and reagent. SGTC_2967 9089538 49.85 µM 0.775525219533805 0.199174624846737 no 670 0.219014684548795 262 728216 SGTC_1382 3002-2117 298 µM 0.775499348563048 0.199182494022693 no 671 0.21902232512741 268 1497314 SGTC_2157 5649910 96.377 µM 0.774653959519159 0.199439739130066 no 672 0.219272081634964 239 2858091 SGTC_2977 9011197 71.43 µM 0.77365186756587 0.199744926587246 no 673 0.219568345392538 250 2704722 SGTC_198 3454-2873 16.191 µM 0.773561140980342 0.199772571263288 no 674 0.21959517962449 256 710957 SGTC_1340 1486-1359 257 µM 0.773517511132211 0.199785866234757 no 675 0.219608084709603 249 4309068 SGTC_43 0570-0105 72.5 µM 0.773272748019785 0.199860460789923 no 676 0.219680490212786 249 1114046 YDL195W SEC31 SGTC_107 0358-0022 2.6945 µM 0.770648746571215 0.200661209260444 no 677 0.220457579576755 242 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1302 1159-0335 255 µM 0.770105205301042 0.200827318493437 no 678 0.220618744266048 233 649284 SGTC_1637 st007924 17.4 µM 0.767754958882564 0.201546516157938 no 679 0.221316389070931 235 683336 SGTC_3341 9147222 25.867 µM 0.766877695716057 0.201815362005155 no 680 0.221577118005751 246 1939759 SGTC_1640 st009078 66.4 µM 0.765880924572863 0.202121092697676 no 681 0.221873578516341 252 690618 SGTC_2296 7971656 126.45 µM 0.765291774156681 0.202301927770139 no 682 0.222048910593265 240 666570 SGTC_2810 7959871 45.46 µM 0.761976679140853 0.203321272959612 no 683 0.223036961502964 244 2974535 SGTC_3025 9087895 49.47 µM 0.76118497173152 0.20356516450161 no 684 0.223273296592738 257 17173641 SGTC_260 nsc-65238 3.989 µM 0.760553640128812 0.203759776032867 no 685 0.22346185949558 241 3246252 SGTC_1534 6-azauridine 81.6 µM 0.75982503195366 0.203984511425323 no 686 0.223679589035288 251 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.75704270503725 0.204844063480641 no 687 0.224512139002068 224 6708630 An antioxidant. SGTC_2282 7944268 200 µM 0.756439034536197 0.205030841056477 no 688 0.224693005939632 257 2970414 SGTC_1884 5633444 25 µM 0.755335808155751 0.205372444245743 no 689 0.22502375924187 261 5724239 SGTC_2357 9067248 200 µM 0.752710307866942 0.206186762857862 no 690 0.225812007193623 259 9150235 SGTC_1424 4048-1941 275 µM 0.74921788256757 0.207272926173931 no 691 0.22686294627963 260 X1424 SGTC_2361 9034121 116 µM 0.74886047734544 0.207384271674766 no 692 0.226970651906865 282 6496917 SGTC_1209 2323-2347 50.3 µM 0.748494899704412 0.207498199774642 no 693 0.227080850155555 233 5412760 SGTC_2518 prenyletin 46.28 µM 0.746872473458608 0.208004256582717 no 694 0.227570271596759 231 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1101 ebselen 5.29 µM 0.74680911349352 0.208024034188582 no 695 0.227589396820486 261 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2398 5228213 48.84 µM 0.74438298631272 0.208782176592052 no 696 0.228322404468195 258 80771 YMR134W ERG29 SGTC_3038 9091290 49.47 µM 0.743582199007222 0.209032772206676 no 697 0.228564637882052 248 25236843 SGTC_325 2810-4341 181 µM 0.743170065922762 0.209161812725146 no 698 0.228689361937942 247 774970 SGTC_910 3454-3003 490 µM 0.7426823612169 0.209314575593085 no 699 0.228837005631432 267 820824 SGTC_814 3342-0569 96 µM 0.742531638272614 0.209361799549108 no 700 0.228882645070465 254 4346283 SGTC_1633 st005664 67.9 µM 0.740976809528573 0.209849318578329 no 701 0.229353750750807 248 2063822 SGTC_1713 st033146 12.748 µM 0.740133259079439 0.210114094156042 no 702 0.229609569781585 260 674619 SGTC_537 1334-0398 209 µM 0.738116862167256 0.210747800191933 no 703 0.230221718926198 251 5846986 SGTC_194 1486-1323 56.904 µM 0.737404767071194 0.210971862493238 no 704 0.230438118680536 252 5178754 SGTC_250 brefeldin a 552.239 µM 0.737255056357155 0.211018987062771 no 705 0.23048362897835 247 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2971 9092186 9.93 µM 0.73683163210373 0.211152302077995 no 706 0.230612372169947 242 25236400 SGTC_635 k038-0028 24.7 µM 0.73386721432563 0.212087029696638 no 707 0.231514835302289 267 4035102 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.731841660049823 0.212727107966038 no 708 0.232132609017098 256 5377381 SGTC_2318 6029776 164 µM 0.731358264822504 0.212880028133032 no 709 0.232280175204727 264 818325 SGTC_3165 9101544 49.47 µM 0.728747424090101 0.213707065583271 no 710 0.233078088807546 256 5002184 SGTC_968 1309-0633 340 µM 0.725822583737573 0.214635787894041 no 711 0.233973770179682 265 3761976 SGTC_2212 7123476 200 µM 0.725140421806447 0.214852731119068 no 712 0.234182944258336 241 1085715 SGTC_2279 7948423 32.93 µM 0.724210218892486 0.215148762274847 no 713 0.234468342926684 230 1247112 SGTC_2536 dehydroabietamide 32.04 µM 0.724157933540467 0.215165408780706 no 714 0.234484390480606 253 3983547 SGTC_773 4358-1457 44.6 µM 0.722135910224261 0.215809749842244 no 715 0.235105460967516 265 1186886 SGTC_1072 oxiconazole 14.9 nM 0.721865446641911 0.215896020901449 no 716 0.235188603503328 246 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1895 st058434 18.3 µM 0.721822914809022 0.215909589301263 no 717 0.235201679585341 284 5393175 SGTC_668 1682-0499 62.6 µM 0.721733637542464 0.215938071920435 no 718 0.23522912849396 269 682214 SGTC_1106 tegaserod maleate 11.7 µM 0.720967068866817 0.21618272414006 no 719 0.235464888079328 263 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2546 rhodinyl acetate 100 µM 0.71994316904113 0.216509754451781 no 720 0.235779993619511 253 6708682 SGTC_3297 9117502 71.43 µM 0.719160972352239 0.216759778309042 no 721 0.236020871501787 242 7453720 SGTC_816 0325-0417 81.3 µM 0.718187782107704 0.217071084924783 no 722 0.23632075516322 272 68101 SGTC_92 0063-0024 660.874 µM 0.716565654302334 0.217590549132658 no 723 0.236821071595179 263 3594437 SGTC_160 3453-0671 289.699 µM 0.716048681474184 0.217756253229103 no 724 0.236980644962289 281 5322268 SGTC_3321 9137793 26.8275 µM 0.715471333287882 0.217941395314892 no 725 0.237158924150196 268 4904192 SGTC_3036 9090181 49.47 µM 0.713984887248411 0.218418481314908 no 726 0.237618262290221 279 25236586 SGTC_683 panaxydol 45 µM 0.713253158813995 0.2186535557994 no 727 0.237844558511514 238 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2970 9090938 41.86 µM 0.712854626924689 0.218781649066871 no 728 0.237967859207506 255 17217104 SGTC_636 0kpi-0074 126 µM 0.710435519813486 0.219560107167236 no 729 0.238717051572752 275 616434 SGTC_535 2293-4129 48.2 µM 0.708019534290996 0.2203391461817 no 730 0.239466563379347 287 396118 YIL048W NEO1 SGTC_2 0422-0095 29 µM 0.707595775760167 0.220475951065968 no 731 0.239598158430775 238 6790840 SGTC_1421 4029-0249 71.4 µM 0.707305130886238 0.220569810087837 no 732 0.239688438845932 277 2894095 SGTC_2273 7815444 169.05 µM 0.704278356771784 0.221548617065117 no 733 0.240629721024007 289 2824616 SGTC_442 cape 100 µM 0.703810542458386 0.221700121417722 no 734 0.24077538371595 255 5281787 SGTC_1945 st075991 56.6 µM 0.702205431954378 0.222220395436931 no 735 0.241275529278176 255 1084980 SGTC_1856 st057054 55.7 µM 0.699666683453257 0.223044715870571 no 736 0.242067743766852 280 1266018 SGTC_2594 a-mangostin 100 µM 0.698596448122001 0.223392737652631 no 737 0.242402132038671 279 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1329 1447-1697 50.6 µM 0.695884056366134 0.224276142379939 no 738 0.243250721416993 265 2840515 SGTC_1695 st026914 34.495 µM 0.69473241679024 0.224651821356478 no 739 0.243611504388461 269 3289191 SGTC_2847 9005661 71.43 µM 0.693127176149283 0.225176065604012 no 740 0.244114872173704 249 2991449 SGTC_255 tunicamycin 200.472 nM 0.692802256797232 0.225282262999729 no 741 0.244216827875147 262 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_259 usnic acid 108.925 µM 0.692589124790881 0.225351938962055 no 742 0.244283718547297 299 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_392 N-ethylmaleimide 8.33 µM 0.692529413328916 0.225371461698041 no 743 0.244302460534105 262 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3310 9130229 44.1445 µM 0.692328460767476 0.22543717041918 no 744 0.244365540386173 269 7761258 SGTC_2125 5246583 200 µM 0.692099177143488 0.225512156252785 no 745 0.244437524197423 273 835267 SGTC_990 3985-0011 41.3 µM 0.691345265201931 0.225758818130908 no 746 0.244674296092969 267 5399565 YGL099W LSG1 SGTC_2003 4023581 200 µM 0.69114392353928 0.225824718098035 no 747 0.244737549892692 271 16641307 SGTC_81 0411-0046 9.971 µM 0.690426115768864 0.2260597480912 no 748 0.244963129086166 269 12925265 SGTC_2709 st078560 56 µM 0.68980303588439 0.226263873618568 no 749 0.245159029635771 295 17250903 SGTC_453 enantio-paf c16 10 µM 0.689085915823238 0.226498936232541 no 750 0.245384601295236 300 13871343 A lipid and platelet activating factor SGTC_3085 9117376 49.47 µM 0.688960621252253 0.226540020305668 no 751 0.245424024416055 270 16480349 SGTC_1882 5615643 20 µM 0.688794577356424 0.22659447255844 no 752 0.24547627429003 263 2253075 SGTC_2950 9072895 21.46 µM 0.688313503937506 0.226752276950692 no 753 0.245627689837158 257 17332245 SGTC_689 0833-0039 98 µM 0.688202607321535 0.22678866267146 no 754 0.245662601127089 310 5374726 SGTC_294 k038-0071 157 µM 0.687776330508962 0.226928556837125 no 755 0.245796821850996 278 24152826 SGTC_61 0978-8327 98.565 µM 0.687274093780617 0.227093441719416 no 756 0.245955010386056 278 6150059 YHR072W ERG7 SGTC_1871 st057448 67.3 µM 0.685884198358812 0.227550097865305 no 757 0.246393067697351 290 691747 SGTC_2744 captopril 92.04 µM 0.685039852153387 0.227827763750737 no 758 0.246659386730674 237 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_940 3232-1287 54.8 µM 0.68370357408734 0.228267592364181 no 759 0.247081183062736 273 1585493 YIL048W NEO1 SGTC_1897 st060201 15 µM 0.682231383425968 0.228752707952421 no 760 0.247546326556341 281 611878 SGTC_2754 granisetron 64.02 µM 0.682193683192924 0.228765138512013 no 761 0.247558244209653 283 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1717 st033143 58.0435 µM 0.681802350410265 0.22889419155491 no 762 0.247681968932463 282 674616 SGTC_450 aminopyrene 156 nM 0.681081309311069 0.22913208219282 no 763 0.247910021488233 277 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1829 berberine 14.4 µM 0.681033777559105 0.229147769052609 no 764 0.24792505887766 276 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2162 5663267 200 µM 0.67940011047128 0.229687292658406 no 765 0.24844218995435 285 6456493 SGTC_2245 6637752 200 µM 0.679214337482499 0.229748689783251 no 766 0.248501032064149 279 681890 SGTC_941 3237-0776 460 µM 0.679118808658183 0.229780265201467 no 767 0.2485312929468 277 760008 SGTC_2986 9022445 71.43 µM 0.678941921654351 0.229838738588714 no 768 0.24858733102794 283 6459286 SGTC_1081 sertraline 6 µM 0.677972556369196 0.230159328732704 no 769 0.248894546954807 275 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3142 9086498 49.47 µM 0.67723463510023 0.2304035429184 no 770 0.249128547928245 270 25236367 SGTC_2608 thymoquinone 42.66 µM 0.676437577570565 0.23066749085249 no 771 0.249381432906509 277 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2520 obtusaquinone 4.71 µM 0.675512196231445 0.230974145400547 no 772 0.24967520266749 280 5967872 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.674784435696511 0.231215471793407 no 773 0.249906365158858 293 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1927 st060202 13.8 µM 0.6746277226985 0.23126745644017 no 774 0.249956157611237 276 688887 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.674315881683742 0.231370919358212 no 775 0.250055254579529 287 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2636 apigenin dimethyl ether 100 µM 0.674080829869857 0.231448922138232 no 776 0.250129963218067 290 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1233 0325-0408 14.2 µM 0.673953914729782 0.23149104547385 no 777 0.250170306723748 281 12874 SGTC_3194 9111903 49.47 µM 0.673235523397453 0.231729561244412 no 778 0.250398732421601 291 17087251 SGTC_875 0709-0210 25.7 µM 0.672299736504852 0.232040460570576 no 779 0.250696448738555 286 6251364 SGTC_1530 rhein 70.4 µM 0.671632564381477 0.232262258921429 no 780 0.250908820912207 284 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3081 9117243 49.47 µM 0.671435227021161 0.232327885432195 no 781 0.250971654975301 283 45595589 SGTC_3090 9117696 49.47 µM 0.670120938336022 0.232765228308997 no 782 0.251390349117935 264 7923821 SGTC_692 k241-0027 77.8 µM 0.669321734361449 0.233031395050208 no 783 0.251645132657049 273 3600480 SGTC_1070 indatraline 8.81 µM 0.668425991428847 0.233329913875975 no 784 0.251930854509102 291 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1876 myriocin 605 nM 0.668107019326866 0.233436266990589 no 785 0.252032640761287 303 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3039 9090270 49.47 µM 0.667845539828657 0.233523470716501 no 786 0.252116096898406 259 17173750 SGTC_468 gf-109203x 121 µM 0.666697006939156 0.233906721700997 no 787 0.252482845505411 256 2396 A protein kinase C inhibitor. SGTC_1256 0570-0116 285 µM 0.666479622904379 0.233979299222273 no 788 0.252552292028873 284 410638 SGTC_2898 9056270 58.44 µM 0.66599638430739 0.234140681691361 no 789 0.252706705741186 239 19154699 SGTC_844 0330-0132 15.3 µM 0.664322039936051 0.23470032257836 no 790 0.253242108862247 283 2828079 SGTC_2692 st077426 47.7 µM 0.663682988685227 0.234914116989325 no 791 0.253446614684074 280 25238571 SGTC_2621 lithochol-11-enic acid 100 µM 0.662898791681168 0.235176616869922 no 792 0.253697687831182 294 6708711 SGTC_2916 7875993 68.79 µM 0.661291025873199 0.235715301976886 no 793 0.254212847747463 306 1299250 SGTC_3059 1327-0034 3 µM 0.660993388885348 0.23581510042798 no 794 0.254308276654172 278 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2707 st078556 66.6 µM 0.659690390107648 0.236252273385888 no 795 0.254726267428145 276 17250899 SGTC_1268 0828-0275 2.46 µM 0.659211489023776 0.236413062993276 no 796 0.254879985121663 289 745337 SGTC_1326 1431-2094 10.8 µM 0.659056593121299 0.236465081719083 no 797 0.25492971400503 298 616278 SGTC_1093 fluphenazine 7.97 µM 0.65820616379954 0.236750793800537 no 798 0.255202832325548 291 6602611 An atypical antipsychotic. SGTC_2541 muurolladie-3-one 83.07 µM 0.657481290821399 0.236994473506791 no 799 0.255435748519565 297 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2114 5491910 81.25 µM 0.656475315748158 0.237332879261143 no 800 0.255759172394628 283 2849228 SGTC_1446 4239-0190 62 µM 0.655824320616191 0.237552012606502 no 801 0.255968583080741 280 1340085 SGTC_1176 0848-0131 83.3 µM 0.65533746479985 0.237715967092546 no 802 0.256125252240923 293 6769040 SGTC_32 0928-0142 34.1 µM 0.654774512495295 0.237905625339874 no 803 0.2563064714128 289 2244242 SGTC_1581 himbacine 57.9 µM 0.654611959815593 0.2379604046601 no 804 0.256358810946157 304 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1148 3909-7663 27.7 µM 0.654195514913762 0.238100775747543 no 805 0.256492925390977 301 4084526 SGTC_3338 9144300 39.5675 µM 0.653185241672896 0.238441497056709 no 806 0.256818431749425 269 4901274 SGTC_1834 st055981 52.8 µM 0.652514208205961 0.238667954981498 no 807 0.257034755057726 280 471719 YDL150W RPC53 SGTC_25 0118-0223 35.662 µM 0.6518324157982 0.238898164279559 no 808 0.257254643792037 295 5333628 SGTC_2050 5263056 171 µM 0.651509337751919 0.239007294963935 no 809 0.257358875660492 272 763468 YGL055W OLE1 SGTC_2479 5617353 43.85 µM 0.650757784905347 0.23926126310874 no 810 0.257601427515855 296 2731746 SGTC_366 0181-0206 4.31 µM 0.649462990147203 0.239699151627654 no 811 0.258019580410428 296 274874 SGTC_253 dyclonine 31.25 µM 0.649461617784958 0.239699615980735 no 812 0.258020023800375 278 3180 An oral anasthetic. SGTC_105 0111-0055 734.78 µM 0.648223269339293 0.24011882410655 no 813 0.258420276879036 276 5179370 SGTC_287 k060-0039 29.6 µM 0.647033175336377 0.240522073338221 no 814 0.258805236270644 286 5861974 SGTC_3153 9100258 49.47 µM 0.645696427985716 0.240975453678242 no 815 0.259237987176338 302 25236848 SGTC_1499 4480-0877 67.3 µM 0.645379441552477 0.241083033093402 no 816 0.25934066137214 277 2861909 SGTC_3126 9127922 49.47 µM 0.645307579554718 0.241107425375459 no 817 0.259363940913587 314 45595682 SGTC_1645 Cervolide 78 µM 0.645139339670998 0.24116453667085 no 818 0.259418446088513 303 23173 A fragrance. SGTC_2778 tioconazole 65.09 nM 0.644139575838175 0.241504071615351 no 819 0.259742464555525 288 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_830 4076-0286 57.8 µM 0.64295422691402 0.241906970212798 no 820 0.260126900655939 288 6866659 SGTC_3265 9137266 49.47 µM 0.641793642942767 0.24230180426662 no 821 0.260503588889489 254 17224265 SGTC_1274 0865-0114 173 µM 0.639523425394302 0.243075147582181 no 822 0.261241239735086 279 870624 SGTC_1819 st053448 58.6 µM 0.638807653164288 0.24331924989438 no 823 0.261474034484773 323 2857616 SGTC_2027 5150920 200 µM 0.637647835707505 0.243715067601975 no 824 0.26185147463496 279 786715 SGTC_1678 st019265 80.2 µM 0.637204783341067 0.243866362390381 no 825 0.261995731180919 297 5367020 SGTC_356 1634-0012 32.5 µM 0.634910865440085 0.244650505953769 no 826 0.2627432751064 307 735457 SGTC_513 4245-1575 41.7 µM 0.634785842901882 0.244693282132156 no 827 0.262784048888394 283 719745 SGTC_1212 0520-0165 585 µM 0.634743581267243 0.244707742765444 no 828 0.262797832468535 331 5403258 SGTC_3292 9120825 59.784 µM 0.634424508759973 0.244816934426226 no 829 0.262901909507235 300 24824900 SGTC_914 3820-6779 408 µM 0.631821370751694 0.24570874839337 no 830 0.263751803724721 277 2893481 SGTC_771 0250-0039 27.3 µM 0.630138924720828 0.246286067479874 no 831 0.264301847247073 308 3005115 SGTC_685 1278-0033 54.9 µM 0.629657634551533 0.246451352361735 no 832 0.264459303221291 302 3590572 SGTC_2532 xanthone 78.9 µM 0.629651078052327 0.246453604407891 no 833 0.26446144853537 274 7020 An insecticide. SGTC_2444 5485484 36.41 µM 0.629458546117432 0.246519740774733 no 834 0.264524449741471 319 6790631 SGTC_571 k831-0106 44.2 µM 0.628913402516064 0.246707053831563 no 835 0.264702875610051 313 4783639 SGTC_3199 9111318 49.47 µM 0.628494653212316 0.24685098915008 no 836 0.264839974090844 277 8548020 SGTC_1608 st001473 40.5 µM 0.628080364021146 0.246993435631392 no 837 0.264975647843337 325 7292267 SGTC_111 0083-0039 52.457 µM 0.624227410722332 0.248320313824903 no 838 0.266239123890654 279 759313 SGTC_1891 st059073 26.2 µM 0.623500390389875 0.248571110226642 no 839 0.26647787289639 302 688754 SGTC_35 0133-0054 64.071 µM 0.620369933222911 0.24965254733972 no 840 0.26750713135235 291 99677 SGTC_1238 0333-0287 48.8 µM 0.620218570966131 0.249704899693877 no 841 0.267556948288115 294 7226 SGTC_639 0833-0042 114 µM 0.620199313723128 0.249711560702393 no 842 0.267563286642351 312 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3119 9125183 49.47 µM 0.619906917835809 0.249812710941609 no 843 0.267659535508606 273 22695334 SGTC_2309 7664088 163.95 µM 0.618736339278271 0.250217873871457 no 844 0.268045033194838 292 704922 SGTC_1747 st037496 66.6 µM 0.618158792902253 0.250417903654039 no 845 0.268235335046823 307 723305 SGTC_244 nsc-207895 1.295 µM 0.617261274986493 0.250728921807223 no 846 0.268531202536782 271 42640 SGTC_1056 3448-1962 115 µM 0.616433602439378 0.251015917542619 no 847 0.268804190763712 302 715507 SGTC_2103 5378138 10 µM 0.616301919554399 0.251061594649766 no 848 0.268847636099689 298 244142 SGTC_3190 9110366 49.47 µM 0.615974404278893 0.251175219599012 no 849 0.268955706518804 287 17123768 SGTC_301 4119-0100 24.5 µM 0.61453330538256 0.251675503314356 no 850 0.269431485767812 315 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_358 0075-0058 9.45 µM 0.614094154597336 0.251828060964407 no 851 0.269576555365421 345 1069125 SGTC_1475 4092-1048 11.7 µM 0.613856542626071 0.251910625909145 no 852 0.269655064703279 315 2881759 SGTC_1239 0337-0584 35.4 µM 0.613730073806215 0.251954576873518 no 853 0.269696855918204 309 914301 YML130C ERO1 SGTC_1264 0783-0040 158 µM 0.611542732324437 0.252715370586058 no 854 0.270420168747752 317 2855798 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.611046160564432 0.252888254834547 no 855 0.270584510647945 317 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2147 5545932 89.7195 µM 0.6097862994314 0.253327161737654 no 856 0.271001689161549 319 797404 SGTC_1030 k029-0042 36.7 µM 0.608811481386611 0.253667040720473 no 857 0.271324701236356 301 6080581 SGTC_569 4130-2812 160 µM 0.607784571058526 0.254025340996776 no 858 0.271665181815083 320 743552 SGTC_1571 st070080 73.4 µM 0.606689705965019 0.254407643693854 no 859 0.272028427490257 298 4315245 SGTC_1451 4152-0210 104 µM 0.606523563561733 0.254465683288676 no 860 0.272083570000702 325 659563 SGTC_57 miconazole 162.5 nM 0.606063568666167 0.254626412455657 no 861 0.272236270870738 295 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2207 7258803 200 µM 0.604196025600685 0.255279505977645 no 862 0.272856661493424 315 3666799 SGTC_2774 tamoxifen 10.92 µM 0.60330560494477 0.255591200639174 no 863 0.273152702482246 302 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3067 9117431 49.47 µM 0.602112944931956 0.256009006405344 no 864 0.273549479157048 323 17150885 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.600237004695892 0.256666895189769 no 865 0.274174147570165 321 7104 SGTC_1654 st012436 41.8 µM 0.59972004099549 0.256848348006697 no 866 0.274346414812545 301 4323132 SGTC_1655 st012546 55.1 µM 0.599511910615895 0.256921420034325 no 867 0.274415784952487 312 720985 YLR208W SEC13 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.598131140047477 0.257406465445719 no 868 0.274876216783166 299 688662 SGTC_1553 gossypol 38.6 µM 0.597826190372574 0.257513654115927 no 869 0.274977956625018 297 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1846 st056244 14.8 µM 0.596854386473054 0.257855394157297 no 870 0.27530230162565 322 5393182 SGTC_3132 9126706 49.47 µM 0.596843662210236 0.257859166714116 no 871 0.275305881958659 329 850858 SGTC_2474 5321570 43.32 µM 0.595934488918454 0.25817909773696 no 872 0.27560949597024 315 2841384 SGTC_3222 9128301 49.47 µM 0.59528231358827 0.258408719860816 no 873 0.275827388118723 288 4911358 SGTC_1231 0242-0792 125 µM 0.595009518023872 0.258504798868717 no 874 0.275918554372164 315 3707635 SGTC_2331 7980721 200 µM 0.594425078803455 0.258710701505335 no 875 0.276113919432957 303 2981221 SGTC_600 1495-0418 41.6 µM 0.591806614943598 0.259634248494719 no 876 0.276990046548504 314 5377768 SGTC_2860 9025725 38.96 µM 0.590737401497707 0.260011854900541 no 877 0.277348191824086 309 40546248 SGTC_2186 6124449 200 µM 0.590194550912219 0.260203677861419 no 878 0.277530112462897 296 3834182 YLR033W RSC58 SGTC_2461 5755302 26.15 µM 0.58962828171851 0.260403853770247 no 879 0.277719943289823 340 2788904 SGTC_1283 0922-0125 16.4 µM 0.587975442660049 0.260988584952315 no 880 0.278274388119241 294 3360884 SGTC_2840 9008771 71.43 µM 0.586466465819084 0.261523010377881 no 881 0.278781045142254 267 2992978 SGTC_1951 sophoraflavanone G 9.2 µM 0.586428487836906 0.261536468059935 no 882 0.278793802494098 306 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_167 3672-0051 66.205 µM 0.585563381192136 0.261843119047624 no 883 0.279084481218312 310 3237971 SGTC_381 3461-2219 42.7 µM 0.58554011454355 0.261851368831829 no 884 0.279092300924532 332 2883159 SGTC_3240 9133527 49.47 µM 0.585371247635563 0.261911248899565 no 885 0.279149058728781 331 17617455 SGTC_645 0845-0943 5.41 µM 0.585090467923209 0.262010828698237 no 886 0.279243443931148 307 1885106 SGTC_2747 doxorubicin 7.63 µM 0.585089609097947 0.262011133314283 no 887 0.279243732652422 263 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_85 0868-0259 160.055 µM 0.584970754175377 0.262053291622902 no 888 0.27928369089291 297 83173 SGTC_3105 9121040 49.47 µM 0.584827611350899 0.262104069560852 no 889 0.279331818253548 265 41448907 SGTC_2061 5245884 80.95 µM 0.583417024975756 0.262604725119929 no 890 0.279806299804709 328 573863 SGTC_923 1900-2434 73.3 µM 0.582468421513131 0.262941685349754 no 891 0.280125603028607 329 5910570 SGTC_1195 1502-0147 41.1 µM 0.582269835237581 0.26301225457292 no 892 0.280192470204882 295 817940 SGTC_2522 biochanin a 4.94 µM 0.581704714088332 0.263213127855201 no 893 0.280382797842516 307 5280373 A possible chelator. SGTC_3063 1327-0034 4 µM 0.58165174511138 0.263231959785059 no 894 0.280400640517999 321 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_80 0159-0065 512.242 µM 0.58144048709905 0.263307074671024 no 895 0.280471808549136 294 1548079 SGTC_2652 actinonin 100 µM 0.581415911737758 0.263315813395658 no 896 0.280480087998454 308 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3345 9148410 3.559 µM 0.580906323725975 0.263497050583621 no 897 0.280651795063808 315 4903596 SGTC_3252 9135871 49.47 µM 0.580053089015645 0.263800649691371 no 898 0.280939408622851 325 17682838 SGTC_3149 9097855 49.47 µM 0.579094403713671 0.26414198304222 no 899 0.281262737967426 291 25236625 YMR079W SEC14 SGTC_3084 9116877 49.47 µM 0.57841122953004 0.264385359753619 no 900 0.281493257107647 299 27241325 SGTC_1796 st049173 110.4 µM 0.577619303122624 0.264667621571957 no 901 0.281760585835858 334 94134 SGTC_1376 2910-0861 41.3 µM 0.577478341224531 0.264717879881956 no 902 0.281808182837704 319 1112859 SGTC_2255 7941087 197.44 µM 0.576965715708143 0.26490069139901 no 903 0.281981307930937 315 935561 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.575851777465699 0.265298162977578 no 904 0.282357686282641 324 229346 A bile salt which induces apoptosis. SGTC_699 0375-0592 111 µM 0.574793724440343 0.265675973930952 no 905 0.282715405736716 287 762578 SGTC_2063 5246145 200 µM 0.572393992057451 0.266533883394925 no 906 0.283527542579594 332 711240 SGTC_3195 9113082 49.47 µM 0.571862197374005 0.266724190602564 no 907 0.283707668049297 311 17018038 SGTC_3072 9116419 49.47 µM 0.571643254462884 0.26680256112203 no 908 0.283781842658061 298 17170162 SGTC_1378 2093-0007 380 nM 0.571318766215345 0.266918732947537 no 909 0.283891791535763 332 3618014 SGTC_2351 9026858 72.31 µM 0.569884589837367 0.267432496198343 no 910 0.284377988725741 334 1409300 SGTC_1878 temozolomide 1 mM 0.568790592441144 0.267824732606344 no 911 0.28474912985392 306 5394 DNA alkylating agent. SGTC_161 4065-0411 162.148 µM 0.56727612471168 0.268368200234147 no 912 0.285263297707927 319 1906281 YLR208W SEC13 SGTC_2940 9060638 45.86 µM 0.564950287968489 0.269203906633619 no 913 0.286053788790038 314 4027022 SGTC_988 1497-1057 103 µM 0.562104594746687 0.27022817758735 no 914 0.287022379005347 339 3533044 SGTC_1502 4534-4282 27.7 µM 0.560490604894496 0.270809977490205 no 915 0.287572423104953 336 3278949 SGTC_2208 7283366 200 µM 0.558323280975134 0.271592221712085 no 916 0.288311825094334 325 898663 SGTC_2201 6605497 169.863 µM 0.558019709216313 0.271701878514189 no 917 0.288415462857773 306 670741 SGTC_383 2324-0395 7.37 µM 0.557866240180794 0.271757323294225 no 918 0.288467863042063 314 3146421 SGTC_2675 theaflavin digallate 100 µM 0.557638042037428 0.271839776366737 no 919 0.288545786889996 308 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_690 glyoxal 20.3 µM 0.557451317895414 0.271907253217138 no 920 0.288609555800922 312 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.556605194606061 0.272213122747513 no 921 0.288898601929021 327 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1893 st059353 36.1 µM 0.556577737036451 0.272223051391749 no 922 0.288907984054429 351 3112488 SGTC_2742 clothiapine 36.27 µM 0.556403561325156 0.272286037438375 no 923 0.288967502434245 317 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3019 9081971 49.47 µM 0.55619236655115 0.272362420163545 no 924 0.289039678504959 323 16451803 SGTC_2999 9069765 71.4286 µM 0.555878802189572 0.272475846484475 no 925 0.289146855145287 293 2097066 SGTC_3054 9094397 49.47 µM 0.555784402907777 0.272509998335999 no 926 0.289179124581868 334 2598354 SGTC_2372 9071633 200 µM 0.555094284913516 0.272759734351232 no 927 0.289415085834985 301 21321366 SGTC_1990 st072050 59.8 µM 0.55503949411026 0.272779566603039 no 928 0.289433823472396 305 17233948 SGTC_2982 9019404 25.97 µM 0.554626124439402 0.272929214246145 no 929 0.289575208098062 284 22333232 SGTC_2935 9038016 29.96 µM 0.55428938694868 0.273051149671593 no 930 0.28969040621817 317 6463195 SGTC_2156 5649887 115 µM 0.552805679402703 0.273588733820451 no 931 0.290198239546699 330 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2884 9058502 51.95 µM 0.551733447928507 0.273977555695267 no 932 0.290565495066036 309 6471554 SGTC_176 1486-1328 72.834 µM 0.549721875843858 0.274707745431237 no 933 0.291255075052902 320 22310231 SGTC_2906 7926292 26.41 µM 0.549345981938116 0.274844299214782 no 934 0.29138401859252 339 2966319 SGTC_2825 7998094 58.44 µM 0.548995101967665 0.274971796183855 no 935 0.291504405588664 318 2987815 SGTC_2069 5228469 200 µM 0.548781542376489 0.275049410203995 no 936 0.291577689286415 340 2835210 SGTC_2116 5511452 16.8835 µM 0.548547728073164 0.275134397772582 no 937 0.291657933306969 337 870744 SGTC_3326 9140064 16.379 µM 0.548194419510192 0.275262844024602 no 938 0.291779206747737 335 1868434 SGTC_387 norethindrone acetate 66.7 µM 0.548164791025224 0.275273616879097 no 939 0.291789377816106 330 541197 SGTC_2064 5220758 200 µM 0.547891385911423 0.275373036192547 no 940 0.29188324198264 307 788518 SGTC_1178 0988-0033 191 µM 0.547395880069757 0.275553263831729 no 941 0.292053392565821 320 5392207 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.546198130119441 0.275989154332654 no 942 0.292464875676836 312 165521 SGTC_191 3914-0123 66.505 µM 0.545672604408237 0.276180512817914 no 943 0.292645503350734 338 3144412 SGTC_743 1275-0778 158 µM 0.545326144177057 0.276306704203129 no 944 0.292764613027092 333 2849257 YMR203W TOM40 SGTC_1521 st012942 49.4 µM 0.544747876696909 0.276517389849152 no 945 0.292963465919192 295 24207259 SGTC_1026 k007-1105 30.6 µM 0.544067425416252 0.276765405909374 no 946 0.293197537702371 317 7066794 SGTC_2124 5246320 200 µM 0.543988315521298 0.276794247555679 no 947 0.293224756729781 330 579342 SGTC_959 1222-0044 107 µM 0.543630584758943 0.276924686333606 no 948 0.293347854355675 334 6083612 SGTC_296 1222-0039 74.9 µM 0.543253645078736 0.277062161784834 no 949 0.293477587807071 306 5984176 SGTC_3049 9092223 49.47 µM 0.54283865624697 0.277213552941365 no 950 0.29362044757558 328 8623917 SGTC_278 4092-0821 23.9 µM 0.540728513457986 0.277983974884946 no 951 0.294347361088421 316 877900 SGTC_632 0781-2353 4.65 µM 0.539770024818 0.278334267840341 no 952 0.294677820721813 333 6811515 YHR007C ERG11 SGTC_2093 5331342 194.4 µM 0.539253944439503 0.278522965635437 no 953 0.294855821405956 333 33839 SGTC_3216 9129716 49.47 µM 0.539184784544313 0.278548257748057 no 954 0.294879679030425 295 8056934 SGTC_977 1348-1378 135 µM 0.536914894683856 0.27937898791501 no 955 0.295663200990034 320 X977 SGTC_512 prima-1 270 µM 0.535580839009486 0.279867784072329 no 956 0.296124137120204 313 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2151 5563267 85.4165 µM 0.535404779268636 0.279932323086859 no 957 0.296184993007496 357 5310824 SGTC_2035 5154463 94.595 µM 0.533844981247791 0.280504420275165 no 958 0.296724395014305 356 2769623 SGTC_3215 9129942 49.47 µM 0.533580398577368 0.280601519076591 no 959 0.296815936347855 345 17682944 SGTC_2395 5646831 180.19 µM 0.533544530324718 0.280614683565066 no 960 0.296828347179263 345 6808628 SGTC_1418 3966-3099 2.4 µM 0.532006090912995 0.281179607940224 no 961 0.297360888473777 332 740335 SGTC_2226 7298446 200 µM 0.531528807258851 0.281354980983722 no 962 0.297526192130605 345 3283010 SGTC_2149 5554786 194.827 µM 0.531508098962042 0.281362591232432 no 963 0.297533365245293 323 745063 YPR165W RHO1 SGTC_1699 st031318 29.054 µM 0.531318837178765 0.281432149080419 no 964 0.297598926997619 335 5340658 SGTC_3307 9126885 69.2785 µM 0.530843999379018 0.281606698880286 no 965 0.297763443518349 317 24824909 SGTC_2327 6189656 200 µM 0.530513657281934 0.281728163022084 no 966 0.297877921239555 354 5349088 SGTC_593 1203-0218 61.7 µM 0.530049501838609 0.281898871920632 no 967 0.298038804930403 344 3666956 SGTC_1997 st073024 93.8 µM 0.529364402257592 0.282150931545177 no 968 0.298276343718073 324 686268 SGTC_3 0833-0587 95.581 µM 0.529089779829226 0.282252000195129 no 969 0.298371585427881 327 5382644 SGTC_1206 3978-0017 132 µM 0.527996496075666 0.282654531507863 no 970 0.298750883957034 339 3873677 SGTC_1285 0929-0069 65.5 µM 0.527847665017876 0.282709350285427 no 971 0.298802535621809 307 1206237 SGTC_341 1486-1430 230 µM 0.527804132324536 0.282725385599437 no 972 0.298817644365127 332 2054753 YPL210C SRP72 SGTC_2523 spermine 47.74 µM 0.52751379896169 0.282832341378146 no 973 0.29891841825188 302 1103 A DNA binding polyamine. SGTC_794 k038-0031 316 µM 0.526079927044363 0.283360849623748 no 974 0.299416337362908 324 6624242 SGTC_1600 coumarin 106 71.1 µM 0.524662621107472 0.28388371674331 no 975 0.29990887310927 354 100336 A hepatotoxic, DNA x-linker. SGTC_2347 9049783 174.81 µM 0.523980644796838 0.284135473310197 no 976 0.300146001039963 355 6467988 YPL169C MEX67 SGTC_1031 k035-0009 16 µM 0.523686266519477 0.284244178197188 no 977 0.300248384616825 352 5180959 SGTC_128 0906-2981 13.371 µM 0.519108655577959 0.28593710295159 no 978 0.301842486361948 336 6740226 SGTC_2944 9067346 25.62 µM 0.51851077750991 0.286158567886169 no 979 0.30205097124359 333 6473075 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.518274306604158 0.286246183500416 no 980 0.302133448389158 364 5393153 SGTC_24 0417-1663 219 µM 0.517670810178128 0.286469844671147 no 981 0.302343983784634 347 4329390 SGTC_2269 7935389 174.42 µM 0.516507202233717 0.286901322110494 no 982 0.302750104993615 346 97605 SGTC_848 0368-0089 85.6 µM 0.515808934300812 0.287160394577675 no 983 0.302993930970978 340 762535 SGTC_3052 9092717 49.47 µM 0.514862041206284 0.287511889159185 no 984 0.303324713882949 338 25237534 SGTC_2281 7943571 200 µM 0.513890706669095 0.287872667847428 no 985 0.303664202646134 342 1244024 SGTC_2516 gossypol 71.55 µM 0.513804915137768 0.287904543306755 no 986 0.303694195584895 330 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_305 1682-2595 20.8 µM 0.510829934890944 0.289010913462561 no 987 0.304735072996093 336 226033 SGTC_2473 5854593 8.94 µM 0.509836873771896 0.28938066928356 no 988 0.30508287506716 348 2872951 SGTC_1558 st069300 45.6 µM 0.507858262357912 0.29011804617836 no 989 0.305776373509549 343 24208000 SGTC_419 nsc-638432 893 µM 0.507257175053231 0.290342230002957 no 990 0.305987191303868 319 368090 SGTC_1524 corynanthine 62.1 µM 0.506833520156635 0.290500286677283 no 991 0.306135817316701 356 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_319 1348-1596 45.5 µM 0.506305158477767 0.290697463645354 no 992 0.306321221136779 360 5380505 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.506237985890301 0.29072253597153 no 993 0.306344795769611 355 61125 An anti-inflammatory. SGTC_918 glabranin 770.725 nM 0.505630126739144 0.290949466797333 no 994 0.306558164119969 336 124049 Also referred to as licorice root. SGTC_1116 jasmonic acid  1.58368 µM 0.504242753689429 0.29146772178884 no 995 0.307045399994826 365 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3281 9140613 49.47 µM 0.501921666529375 0.292335728378676 no 996 0.30786131191032 301 16013766 SGTC_718 1130-0073 349 µM 0.501365942853083 0.292543728103709 no 997 0.308056801942024 345 6740020 SGTC_2080 5212524 12.4 µM 0.501139399254614 0.292628539983149 no 998 0.30813651008566 349 260183 SGTC_2846 9008642 19.48 µM 0.499894363566612 0.293094851893125 no 999 0.308574730633553 359 2992898 SGTC_1909 st060837 51.5 µM 0.499225126095358 0.293345648410987 no 1000 0.308810397787551 366 678937 SGTC_843 0310-0051 143 µM 0.498977883547007 0.293438327622696 no 1001 0.308897482394588 348 2065037 SGTC_1847 st056231 15 µM 0.498758683609623 0.293520506364909 no 1002 0.308974698723767 329 5393180 SGTC_796 1234-0020 70.7 µM 0.497403869572586 0.294028666742736 no 1003 0.309452138682957 322 46495034 SGTC_2842 9000675 19.48 µM 0.496244516051179 0.294463836910756 no 1004 0.309860953427028 329 2989072 SGTC_3327 9140648 26.9345 µM 0.4955992502144 0.294706169944768 no 1005 0.310088590955969 371 8029710 SGTC_1880 MG-132 525 µM 0.495171792151044 0.294866754733028 no 1006 0.310239430136535 349 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_789 1309-1135 70.6 µM 0.494513621298757 0.295114091093614 no 1007 0.310471744472847 333 3092424 SGTC_1076 itraconazole 331 nM 0.494073271625792 0.295279624985947 no 1008 0.310627216772375 326 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1367 1812-0510 76.9 µM 0.491994716097988 0.296061560748704 no 1009 0.311361539448048 325 1142582 YDR527W RBA50 SGTC_1972 st070201 17.4 µM 0.491584169385604 0.296216117419865 no 1010 0.311506668411429 339 2829099 SGTC_285 1486-1325 46 µM 0.491407093725307 0.296282791718271 no 1011 0.311569274002505 344 22310230 SGTC_976 1348-1067 47.6 µM 0.490566464564034 0.296599407664438 no 1012 0.311866555070684 337 5310671 YGL099W LSG1 SGTC_3287 9117173 37.0625 µM 0.488960303671653 0.297204785294693 no 1013 0.312434900492239 321 2789709 SGTC_1346 1488-2224 62.4 µM 0.48828619817852 0.297459030348742 no 1014 0.312673568077794 344 3722427 SGTC_1546 5-methoxyflavanone 78.7 µM 0.488134186593158 0.297516376629943 no 1015 0.31272739876009 322 147795 SGTC_3096 9117468 49.47 µM 0.487732135326951 0.297668074558462 no 1016 0.31286979330432 333 41316311 SGTC_1650 st011916 45.8 µM 0.486666788026116 0.298070211226173 no 1017 0.313247242471088 367 242528 SGTC_283 0987-0079 11.7 µM 0.486359007052684 0.298186435388512 no 1018 0.313356324752068 352 411556 SGTC_435 c-PAF 6.7 µM 0.48615360116778 0.298264012181914 no 1019 0.313429132823242 339 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_399 oxolinic acid 75 µM 0.484238169741219 0.298987865895198 no 1020 0.314108425442245 338 4628 A DNA gyrase inhibitor. SGTC_879 0831-1030 162 µM 0.483777379842481 0.299162120303284 no 1021 0.314271935071804 338 1549252 SGTC_1811 st050069 61.5 µM 0.483272552626072 0.299353080956747 no 1022 0.314451113029165 353 3877702 SGTC_2657 nystatin 74.44 µM 0.48183316759335 0.29989785945265 no 1023 0.314962232831679 339 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3286 9117135 37.221 µM 0.481337165622104 0.300085690203223 no 1024 0.315138443317667 337 3438150 SGTC_130 0136-0219 337.655 µM 0.479777329626945 0.300676730253667 no 1025 0.315692867307206 380 234244 SGTC_2232 chlorophetanol 41.5365 µM 0.479285628709989 0.300863150322962 no 1026 0.315867722275649 351 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2586 curcumin 80 µM 0.479054587618017 0.300950763636315 no 1027 0.315949897598703 335 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1152 3909-8331 15.9 µM 0.478396695242263 0.301200306626718 no 1028 0.316183942665105 369 16001939 SGTC_565 1418-0001 44.5 µM 0.477833299763688 0.301414080370354 no 1029 0.316384429044518 351 2862145 SGTC_3272 9137413 49.47 µM 0.477633530074404 0.301489897011511 no 1030 0.316455530798595 351 17614870 SGTC_2920 7982904 15.77 µM 0.477037768958581 0.301716051356428 no 1031 0.31666761355705 351 6456808 SGTC_924 2046-0044 21.3 µM 0.476835506797265 0.301792848575741 no 1032 0.31673962981306 327 3623589 SGTC_2038 4100038 30.985 µM 0.476598423742727 0.301882878175469 no 1033 0.316824053030619 346 3596803 SGTC_1921 5740136 50 µM 0.472900369549136 0.303288731490605 no 1034 0.318142130639663 366 1774243 SGTC_214 4373-3496 70 µM 0.472484213930637 0.303447120363267 no 1035 0.318290603433222 354 3779166 SGTC_2556 citropten 84.59 µM 0.472026243049099 0.303621466824861 no 1036 0.318454028497734 304 2775 A potential DNA crosslinker. SGTC_1052 3253-3998 198 µM 0.471207642419818 0.303933213980864 no 1037 0.318746230837745 326 5450317 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.470840255939248 0.304073171929503 no 1038 0.318877407378669 364 368090 SGTC_2182 6325192 200 µM 0.470640456615607 0.304149298663463 no 1039 0.318948755906099 338 736248 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.470403392128606 0.304239635033608 no 1040 0.319033420561713 342 688669 SGTC_2457 5731572 11.68 µM 0.467048196580233 0.305519453222236 no 1041 0.320232697975235 378 2865357 SGTC_847 0342-0274 5.54 µM 0.465542050470624 0.306094738181755 no 1042 0.320771665459851 366 18097 SGTC_3328 9140624 29.0385 µM 0.465378090671769 0.306157392890477 no 1043 0.320830360556802 345 4904392 SGTC_1854 st056233 32.9 µM 0.464880093858434 0.306347729453997 no 1044 0.321008663244815 355 5393174 SGTC_1859 st055998 20 µM 0.461698312388159 0.307565052338342 no 1045 0.322148840734914 348 676301 SGTC_326 k292-0812 17.5 µM 0.46154599613373 0.307623380589232 no 1046 0.322203464712702 367 3579357 SGTC_1720 st037298 9.481 µM 0.460866416421675 0.307883679264683 no 1047 0.32244722380377 373 597396 SGTC_1146 3579-1023 7 µM 0.460386494757351 0.308067561405992 no 1048 0.32261941336751 360 X1146 SGTC_971 1315-0384 26.7 µM 0.458738221482659 0.308699464606438 no 1049 0.323211081633161 369 6769120 SGTC_2596 sinensetin 100 µM 0.458305427290624 0.308865480181765 no 1050 0.323366512747186 348 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1979 st071809 45.3 µM 0.455288691485772 0.310023753716052 no 1051 0.324450780392169 374 4976333 SGTC_3087 9117406 49.47 µM 0.455187034085736 0.310062817943455 no 1052 0.324487343839962 312 42546093 SGTC_2959 9079155 11 µM 0.455182767119877 0.310064457671512 no 1053 0.324488878590456 376 16189457 SGTC_2639 lactacystin 53 µM 0.453958473516025 0.310535090419636 no 1054 0.324929357911306 337 3870 A proteasome inhibitor. SGTC_720 r052-1644 49.9 µM 0.453324417919461 0.310778950807054 no 1055 0.325157576254248 356 1422863 YOR257W CDC31 SGTC_2981 9013952 38.96 µM 0.451526165569285 0.311471018063363 no 1056 0.325805185561104 314 2996344 SGTC_908 3448-7491 47.7 µM 0.447299771021786 0.313100190730374 no 1057 0.327329316149588 320 1203031 SGTC_1696 st025591 34.7925 µM 0.447145973804718 0.313159544948644 no 1058 0.327384833316109 348 2787147 SGTC_2483 5729050 27.16 µM 0.445362886437144 0.313848036367051 no 1059 0.328028764246551 376 2865180 SGTC_1765 st044815 90.4 µM 0.444202647933189 0.314296379921409 no 1060 0.328448038998095 358 645695 SGTC_444 curcumin 90.4 µM 0.443764183943413 0.314465884164822 no 1061 0.328606542789032 359 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1776 st049249 45.9 µM 0.443535785992276 0.314554195219848 no 1062 0.328689120377504 344 1822314 SGTC_3316 9136639 10.545 µM 0.441596383738764 0.315304500654776 no 1063 0.329390650654424 362 4903665 SGTC_467 ro 31-8220 72.8 µM 0.440469818059783 0.315740690556287 no 1064 0.329798433743213 368 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2746 daunorubicin 9.88 µM 0.440451393848995 0.315747826279146 no 1065 0.329805104439848 351 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_96 0929-0093 37.281 µM 0.439733271174369 0.316026009690704 no 1066 0.330065151139616 340 6991579 SGTC_507 nimesulide 162 µM 0.439176566686279 0.316241735299178 no 1067 0.330266801579069 368 4495 A COX2 inhibitor. SGTC_1479 0549-0158 134 µM 0.438104141026181 0.316657481581534 no 1068 0.330655396350469 323 5440202 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.437718697285745 0.316806962840807 no 1069 0.330795107000648 353 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1987 st072290 61.9 µM 0.437391966464429 0.316933697716368 no 1070 0.330913554614362 375 54697379 SGTC_2377 9073351 62.6 µM 0.435455108301539 0.317685421944301 no 1071 0.331616058564276 382 7337946 YHR072W ERG7 SGTC_2382 9035899 200 µM 0.434753696386027 0.317957836312136 no 1072 0.331870608965219 374 6462679 SGTC_852 0418-0143 439 µM 0.434603205508241 0.318016296804536 no 1073 0.331925233943609 351 5369229 SGTC_2720 fluspirilene 36.88 µM 0.43409292321092 0.318214557550482 no 1074 0.33211048212262 363 3396 An atypical antipsychotic. SGTC_2779 methotrexate 400 µM 0.433516756587939 0.318438479046036 no 1075 0.332319697666483 383 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1772 st048439 82.2 µM 0.431748819375364 0.319125984292489 no 1076 0.332961990627795 328 2927068 YDL195W SEC31 SGTC_1594 piperine 70.1 µM 0.431547985321311 0.319204122905658 no 1077 0.333034984847737 359 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1009 4106-0057 9.87 µM 0.431495681564577 0.319224474074829 no 1078 0.333053995968653 376 2928005 SGTC_3293 9120939 62.045 µM 0.431052348051044 0.319396995130656 no 1079 0.33321515395431 381 934087 SGTC_1396 3511-0007 98.6 µM 0.430719590376941 0.319526511836063 no 1080 0.333336136299022 383 X1396 SGTC_2948 9070189 9.45 µM 0.429048841724353 0.32017713699921 no 1081 0.333943840500161 354 6473636 YDL196W YDL196W SGTC_3230 9131665 49.47 µM 0.428918740193755 0.320227824555901 no 1082 0.333991180853598 372 15943720 SGTC_2052 5265182 7.135 µM 0.427240267295734 0.320882058148782 no 1083 0.334602167442741 381 1239884 SGTC_2198 6589944 200 µM 0.426458157437295 0.321187098427282 no 1084 0.334887015679408 346 5290268 SGTC_99 0109-0120 622.8 µM 0.426365690522669 0.321223170566578 no 1085 0.334920698866141 382 759414 SGTC_1926 methyl fluorone black 53.6 µM 0.425222897457592 0.321669123128609 no 1086 0.335337096907852 334 72721 Reacts with homocysteine. SGTC_2886 9058944 51.95 µM 0.425180824845449 0.321685546049732 no 1087 0.335352430717042 353 4949929 SGTC_3187 9109394 49.47 µM 0.421835819681829 0.322992371859363 no 1088 0.336572429269156 356 17098090 SGTC_2748 diazoxide 86.69 µM 0.421267145777353 0.323214759309215 no 1089 0.336780009059265 362 3019 A potassium channel activatior. SGTC_1348 1493-0373 93.8 µM 0.420947593087718 0.323339752351 no 1090 0.336896675383188 392 3010129 SGTC_973 1325-0077 65.9 µM 0.420632514788486 0.32346301476063 no 1091 0.337011723506633 387 2835149 SGTC_390 dec-rvkr-cmk 16.7 µM 0.420562417191371 0.323490440416707 no 1092 0.337037321113566 357 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1061 3448-9325 110 µM 0.420435672304833 0.323540031735872 no 1093 0.337083606581378 398 723482 SGTC_1258 0671-0043 57.1 µM 0.42023917727522 0.323616920305476 no 1094 0.337155368706136 377 4298767 SGTC_900 1112-0045 141 µM 0.41954260578685 0.323889549603546 no 1095 0.337409811923634 354 56211 YIL048W NEO1 SGTC_2715 st079500 56.4 µM 0.418125241218804 0.324444579897325 no 1096 0.337927775517795 358 28246688 SGTC_739 1486-1183 203 µM 0.41793478618217 0.324519190556158 no 1097 0.337997399080727 385 4346692 SGTC_906 1165-0455 526 µM 0.41714103982042 0.324830216091625 no 1098 0.338287624072912 369 3252859 SGTC_994 3910-0338 138 µM 0.416374929927171 0.32513052827326 no 1099 0.33856783523264 368 3479481 SGTC_516 3992-2719 87.3 µM 0.415309226329789 0.325548469002596 no 1100 0.338957773963144 355 5350887 YDR037W KRS1 SGTC_3144 9087057 49.47 µM 0.415164894949547 0.325605088830325 no 1101 0.339010597795817 405 17249618 SGTC_2899 9053889 58.44 µM 0.414277384856048 0.325953339005173 no 1102 0.33933548710004 377 6470052 SGTC_2305 7443522 69.23 µM 0.413344991827869 0.326319364404801 no 1103 0.33967693531133 378 5415886 SGTC_207 4185-0010 4.486 µM 0.412792941236311 0.326536159351208 no 1104 0.339879161772463 378 3761753 SGTC_2101 5377231 179.231 µM 0.411612714753539 0.326999840778283 no 1105 0.34031165534562 386 2844213 SGTC_1676 st018489 23.4 µM 0.411506528936571 0.327041571638608 no 1106 0.340350577412234 351 3696235 SGTC_495 decylubiquinone 155 µM 0.411026742297487 0.327230153995016 no 1107 0.340526462846113 397 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_953 1188-0045 9.7 µM 0.410240610600611 0.327539242026336 no 1108 0.340814726569962 383 6144426 SGTC_2462 5162487 171.77 µM 0.408861668729763 0.32808169423445 no 1109 0.341320590164352 397 2259986 SGTC_3243 9134147 49.47 µM 0.408597442605196 0.328185677738584 no 1110 0.341417553876653 377 24282180 SGTC_2780 5215298 71.43 µM 0.408523255081985 0.328214875878288 no 1111 0.341444780537529 384 2834131 SGTC_2337 9009472 200 µM 0.4077155981988 0.328532814974352 no 1112 0.341741242235558 393 5742383 SGTC_1518 st038567 90.8 µM 0.405657430281875 0.329343586460078 no 1113 0.342497162472864 385 77966 SGTC_247 mechlorethamine 29.705 µM 0.405341014626974 0.329468302996299 no 1114 0.34261343111179 370 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2098 5376439 882.5 nM 0.404764718428985 0.329695501258129 no 1115 0.342825232567044 380 2844116 SGTC_2757 clomiphene 4.22 µM 0.404087215915944 0.329962679353164 no 1116 0.343074292741405 407 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2175 5807670 165.306 µM 0.403761929402116 0.330090989317279 no 1117 0.343193897222466 353 241186 SGTC_1888 azatryptophan 97.5 µM 0.403665018572162 0.330129219867455 no 1118 0.34322953336843 349 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.403545628274975 0.330176320826963 no 1119 0.343273437602887 376 756377 SGTC_1832 st054113 55 µM 0.402622487210919 0.330540602289221 no 1120 0.343612982136736 371 1251267 SGTC_113 0099-0221 2.5 µM 0.402510897829805 0.330584647554533 no 1121 0.343654034868853 395 89219 SGTC_870 0573-2213 57.6 µM 0.402361725395329 0.33064353083119 no 1122 0.343708916949136 349 3916321 SGTC_1476 4112-3294 3.34 µM 0.402353437865153 0.330646802315431 no 1123 0.343711966113737 384 704369 SGTC_1248 0469-0687 58.6 µM 0.401151934533281 0.331121229899036 no 1124 0.344154133111709 372 4017482 SGTC_1459 k035-0031 35.7 µM 0.40049354404017 0.331381318150113 no 1125 0.344396518804023 360 3877128 YMR208W ERG12 SGTC_2801 7907800 81.82 µM 0.400411675786244 0.331413664784351 no 1126 0.344426662976373 389 6620925 SGTC_1184 1269-1718 139 µM 0.400276784578476 0.331466963846166 no 1127 0.344476332537833 356 5403821 SGTC_1775 st081588 35.1725 µM 0.39922886593838 0.331881140228028 no 1128 0.344862287813295 368 1426443 YGL099W LSG1 SGTC_687 k029-0044 34.9 µM 0.398811165753777 0.332046288181625 no 1129 0.345016174554883 407 5829338 SGTC_150 3970-0969 77.2 µM 0.397870147850356 0.332418462078275 no 1130 0.345362952955733 367 6615640 SGTC_2563 tomatine 8.54 µM 0.397511681811287 0.332560279392259 no 1131 0.345495086928798 415 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1412 3909-8563 178 µM 0.397314150204001 0.332638437630793 no 1132 0.345567906995662 397 23767530 SGTC_2425 5628681 7.85 µM 0.394965796996533 0.333568177892287 no 1133 0.346434065075766 373 5714958 SGTC_2427 5545055 42.75 µM 0.394309109149072 0.333828351526001 no 1134 0.346676419418041 379 5372858 SGTC_3050 9093513 49.47 µM 0.392251755762629 0.334643972707047 no 1135 0.347436103177219 378 25236664 SGTC_103 0844-0104 51.839 µM 0.390973361274453 0.335151175546256 no 1136 0.347908463209299 362 5375804 SGTC_1185 1319-0113 81.3 µM 0.3905505424116 0.33531899509704 no 1137 0.348064744554238 389 4672763 SGTC_1371 2421-0008 32.7 µM 0.388976531357184 0.335944019008866 no 1138 0.348646753619694 391 2827552 SGTC_505 gw-5074 63.9 µM 0.38882133401771 0.33600567092112 no 1139 0.348704158983271 392 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3086 9117350 49.47 µM 0.387351741157583 0.336589683009642 no 1140 0.349247912736866 365 2679265 SGTC_1969 st069479 40.1 µM 0.386369108644346 0.336980398524857 no 1141 0.34961166249246 413 3895485 SGTC_2025 5147754 141 µM 0.38463769031967 0.337669275117442 no 1142 0.350252932833821 377 315777 YLR208W SEC13 SGTC_2480 5767542 37.17 µM 0.383606777023018 0.338079701574285 no 1143 0.350634958145735 392 2867358 SGTC_1158 4092-0494 91.8 µM 0.383460833583205 0.338137820039238 no 1144 0.350689052592027 382 1148199 SGTC_1799 st045822 46.1415 µM 0.381777858705815 0.338808302733687 no 1145 0.351313071613375 414 3674992 SGTC_1205 4161-2785 76 µM 0.381426508440731 0.338948342205689 no 1146 0.351443397089141 355 3498106 SGTC_1290 0986-0249 10.2 µM 0.379657835448316 0.339653628959308 no 1147 0.352099711530605 393 53329 SGTC_2741 miltefosine 3.04 µM 0.378481447720571 0.340123043744347 no 1148 0.352536486577364 398 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2815 7968870 71.43 µM 0.377623616804755 0.340465500947332 no 1149 0.352855108942824 382 2977326 YHR190W ERG9 SGTC_1128 3448-9350 235 µM 0.377342280965475 0.340577842522915 no 1150 0.352959627421886 321 619386 SGTC_1805 st050013 60.3 µM 0.373228994366085 0.342221949594959 no 1151 0.354489009180445 396 4037144 SGTC_876 0720-0963 56.8 µM 0.372160534592521 0.342649511165907 no 1152 0.354886663927289 405 765861 SGTC_2568 diosmetin 100 µM 0.370816690626577 0.343187558498449 no 1153 0.355387034477748 404 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_48 0382-0018 55 µM 0.370077373629224 0.34348370142793 no 1154 0.355662420196559 337 762596 SGTC_527 4476-4215 268 µM 0.369829024950875 0.3435832022575 no 1155 0.355754943681131 365 4418754 SGTC_2848 9016370 25.97 µM 0.368639917908953 0.344059767753485 no 1156 0.356198068854245 386 7894410 SGTC_601 0986-0029 62.9 µM 0.366602470720607 0.344876903289249 no 1157 0.356957782492798 397 24747981 SGTC_656 4090-1979 187 µM 0.366063693127587 0.34509310583689 no 1158 0.357158774340736 395 22330961 SGTC_2380 9035439 200 µM 0.365666276048809 0.345252615161805 no 1159 0.357307056831094 380 6462575 SGTC_151 3013-0144 2.285 µM 0.36427820068763 0.345809955646249 no 1160 0.357825138278466 416 906558 YHR107C CDC12 SGTC_558 k064-0027 21.3 µM 0.364098071920594 0.345882305539715 no 1161 0.357892388272775 380 5088526 SGTC_2730 imipramine 71.33 µM 0.363628844345707 0.346070800272218 no 1162 0.358067592277422 350 3696 A tricyclic antidepressant. SGTC_1725 st036284 20.55 µM 0.36284386899759 0.346386220200318 no 1163 0.358360759576512 386 707914 SGTC_1795 st049545 62.3 µM 0.362045015600198 0.346707326032522 no 1164 0.358659195695485 365 5291882 SGTC_1817 st052116 64.4 µM 0.361681154157194 0.346853619722873 no 1165 0.358795155890609 365 4361398 SGTC_868 0527-0199 213 µM 0.360900579716796 0.347167533547558 no 1166 0.359086885100943 367 2849450 SGTC_3116 9124943 49.47 µM 0.359219173227859 0.347844079773793 no 1167 0.359715567201794 350 41905195 YPL160W CDC60 SGTC_1824 st053723 68.6 µM 0.358921062493174 0.347964081010724 no 1168 0.35982707123909 386 675225 SGTC_886 0866-0150 153 µM 0.358893835040383 0.347975041885113 no 1169 0.359837255871385 403 271463 SGTC_1769 st044406 64.4 µM 0.358822021652719 0.348003952195536 no 1170 0.359864118683386 415 670903 SGTC_1226 3909-7979 35.4 µM 0.357252425567495 0.348636053553198 no 1171 0.360451420963709 383 6615510 SGTC_3008 9078912 71.4286 µM 0.355753832354423 0.349239953343838 no 1172 0.361012463224413 410 16648731 SGTC_581 0958-0271 211 µM 0.355657949385554 0.349278605066686 no 1173 0.361048370017482 368 4591145 SGTC_809 3998-0021 90 µM 0.354100001037602 0.34990685393896 no 1174 0.361631970654375 424 715485 SGTC_543 3844-1095 191 µM 0.354004269636924 0.349945471431993 no 1175 0.36166784173329 405 4230703 SGTC_2616 abietic acid 100 µM 0.352862067564692 0.350406348774858 no 1176 0.362095924791233 403 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2160 5660466 132.927 µM 0.352094439126603 0.350716209890363 no 1177 0.362383719323892 404 2859134 SGTC_56 0957-0365 83.25 µM 0.350888197746646 0.35120332225706 no 1178 0.362836113036674 383 6752360 SGTC_1491 4138-0063 26.5 µM 0.34896044576792 0.351982307270999 no 1179 0.363559502418015 396 23883227 SGTC_6 0844-0013 19.835 µM 0.348495421349609 0.352170312109028 no 1180 0.363734075906382 403 1584900 SGTC_667 1498-1044 59 µM 0.344915143478545 0.353618990605063 no 1181 0.365079082796071 416 6739982 SGTC_588 3970-1144 52.9 µM 0.344269819832691 0.353880332613878 no 1182 0.36532168945147 391 1888707 SGTC_2144 5628481 200 µM 0.343970911190828 0.35400140744147 no 1183 0.365434081144761 376 2818399 SGTC_1088 bifonazole 369 nM 0.342626908216897 0.354545986589062 no 1184 0.365939578124441 389 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2793 7325131 81.82 µM 0.342001591990524 0.354799461137568 no 1185 0.366174847094592 390 4176441 SGTC_126 0417-1624 672.48 µM 0.341092668177394 0.355168011831458 no 1186 0.366516910286646 439 41912 YDL195W SEC31 SGTC_2598 perillyl alcohol 100 µM 0.340657036250539 0.355344700058059 no 1187 0.366680893048182 378 10819 An apoptosis inducer. SGTC_1956 st077085 54 µM 0.340331081741341 0.355476924494214 no 1188 0.366803606403375 429 24208685 SGTC_2420 aureobasidin a 50 nM 0.339423120954457 0.355845333220989 no 1189 0.367145501654135 359 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2243 6634756 200 µM 0.337525208693819 0.356615853335004 no 1190 0.367860506059916 351 885676 SGTC_3257 9139206 32.98 µM 0.336672507384384 0.356962226393859 no 1191 0.368181895289331 410 4910041 SGTC_1865 st057639 52.2 µM 0.336335414138333 0.357099188502775 no 1192 0.368308973609597 393 688818 SGTC_2936 9038235 15.59 µM 0.333692231346417 0.35817375958246 no 1193 0.369305906195407 388 4749415 SGTC_42 0133-0086 60.653 µM 0.33349693898387 0.358253199303075 no 1194 0.369379599837098 439 162923 Model of phenazepam hydroxylation. SGTC_290 2043-6722 48.1 µM 0.333294930669822 0.358335377349794 no 1195 0.369455832795627 410 773758 YLR208W SEC13 SGTC_193 1273-0060 1.558 µM 0.333221113309768 0.358365408278105 no 1196 0.369483690928475 396 2847393 YHR072W ERG7 SGTC_1885 st057546 99.9 µM 0.332360417509066 0.358715627568812 no 1197 0.369808561780603 388 702008 SGTC_2272 7805186 180 µM 0.332249283827549 0.358760856812119 no 1198 0.369850516126479 442 2956062 YPR165W RHO1 SGTC_1694 st024011 44.9 µM 0.331234035679486 0.359174134651185 no 1199 0.370233856579883 417 2787533 SGTC_1316 1272-0050 65.9 µM 0.330703820004122 0.359390035508595 no 1200 0.370434108284665 405 7340392 SGTC_859 0439-0102 54.6 µM 0.328418934262284 0.360320941075678 no 1201 0.37129746437121 408 610143 SGTC_2100 5377183 190 µM 0.327782346831633 0.360580446646567 no 1202 0.371538117887365 392 2844202 SGTC_3294 9122953 26.2835 µM 0.326562494628745 0.36107790010718 no 1203 0.371999407235904 415 16459826 SGTC_781 4335-2806 94.4 µM 0.326148001332582 0.361246983247999 no 1204 0.37215619050305 418 845254 SGTC_2128 5255449 168.493 µM 0.324508542969209 0.361916028497089 no 1205 0.372776527779473 360 736008 SGTC_708 3448-5400 146 µM 0.324207988467478 0.362038727399238 no 1206 0.372890287263321 408 3462195 SGTC_1477 0139-0234 16 µM 0.323328582731173 0.362397818955498 no 1207 0.373223204814834 380 620880 SGTC_3277 9138724 49.47 µM 0.321032687267969 0.363335881994874 no 1208 0.374092810014893 419 15943418 SGTC_1982 st072467 71.9 µM 0.320781173871783 0.36343869595139 no 1209 0.374188113567553 405 3163533 SGTC_1161 k007-0610 110 µM 0.319362395633507 0.364018849945908 no 1210 0.374725861435019 407 5843850 SGTC_2524 avocatin b 10.57 µM 0.319247366286298 0.364065900390853 no 1211 0.374769470757756 412 6710748 SGTC_3296 9122258 64.045 µM 0.319192267669968 0.364088438099483 no 1212 0.374790360023468 409 4730474 SGTC_2856 9022925 19.48 µM 0.318709751254182 0.364285828183877 no 1213 0.374973309773916 389 4944862 SGTC_2363 9053361 176 µM 0.318534131892502 0.364357680317197 no 1214 0.37503990416993 425 6469797 YMR079W SEC14 SGTC_3139 9095020 49.47 µM 0.318484553514873 0.364377965459518 no 1215 0.375058704833581 408 25236292 SGTC_3184 9108758 49.47 µM 0.318136782771946 0.364520267579622 no 1216 0.37519059164949 413 902885 SGTC_1786 berberine 21.6 µM 0.317340428034462 0.364846193265143 no 1217 0.375492652131547 431 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1965 Pectolinarigenin 58.4 µM 0.316601608629123 0.365148658718711 no 1218 0.375772957510258 390 5320438 An anti-inflammatory. SGTC_2765 myclobutanil 7.74 µM 0.316271333058779 0.365283897465403 no 1219 0.375898284070208 423 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_62 0180-0423 3.232 µM 0.316148460670998 0.36533421459976 no 1220 0.375944912639857 416 30102 YGL099W LSG1 SGTC_88 0180-0332 8.668 µM 0.313897744083215 0.366256308688487 no 1221 0.376799351908044 377 3101745 SGTC_1928 4'-methoxychalcone 40.3 µM 0.312662642731151 0.366762645025227 no 1222 0.377268490148989 432 641818 SGTC_925 2064-1272 59.6 µM 0.311264618313481 0.367336052342447 no 1223 0.377799731334799 415 6815817 SGTC_190 3970-0790 3.722 µM 0.310873703936678 0.367496441003886 no 1224 0.377948317941803 408 2832352 SGTC_3117 9124945 49.47 µM 0.310692942292702 0.367570613702246 no 1225 0.378017031573832 386 17592065 SGTC_1968 st069590 43.6 µM 0.31053064443626 0.367637214284918 no 1226 0.378078729782019 415 6384066 SGTC_2994 9053520 71.4286 µM 0.310366961843379 0.367704387140165 no 1227 0.378140957553027 425 4647384 SGTC_3206 9114350 49.47 µM 0.308580850366088 0.368437642841907 no 1228 0.378820194800771 429 17087243 SGTC_192 3455-0609 60.9 µM 0.308041531420558 0.368659144814332 no 1229 0.379025365167701 389 3769639 SGTC_2763 lisinopril 49.32 µM 0.307839991443362 0.368741929864633 no 1230 0.379102044749835 433 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2705 st078069 42.8 µM 0.306608049383344 0.369248097660524 no 1231 0.379570863026682 409 1530061 SGTC_1648 st011736 69.8 µM 0.305179901467443 0.369835164308569 no 1232 0.380114569509587 403 2855514 SGTC_1363 1636-0063 10.4 µM 0.304646556095556 0.370054483708049 no 1233 0.38031767888094 433 6072185 SGTC_956 1185-0240 191 µM 0.304087221162501 0.370284535797363 no 1234 0.380530721090266 402 1416193 SGTC_1484 3473-2379 286 µM 0.302972781617779 0.370743038335968 no 1235 0.380955302215824 440 671917 SGTC_2583 asiatic acid 100 µM 0.302839253013964 0.370797986983615 no 1236 0.381006183805091 449 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1456 k015-0012 13 µM 0.302368454842347 0.370991747186382 no 1237 0.38118559967451 418 2989616 SGTC_2079 5212404 121 µM 0.302095347166245 0.37110416151118 no 1238 0.381289689635875 394 758462 SGTC_3162 9099653 49.47 µM 0.301489396813263 0.37135361705162 no 1239 0.38152066711018 401 25237511 SGTC_2004 4023728 41.89 µM 0.301399015209275 0.371390829671623 no 1240 0.381555122585248 449 360084 YDR527W RBA50 SGTC_648 0375-0473 33.3 µM 0.301302767551239 0.371430458830971 no 1241 0.381591815362382 423 1713139 SGTC_223 busulfan 5 mM 0.301102116565914 0.371513079559422 no 1242 0.381668313547537 420 2478 A DNA alkylator. SGTC_3157 9099274 49.47 µM 0.30035730634688 0.371819816878109 no 1243 0.381952312830242 436 17217662 SGTC_2571 chrysanthemic acid 100 µM 0.300135003935369 0.371911384094052 no 1244 0.38203708999788 423 2743 An insecticide. SGTC_3010 9080089 71.4286 µM 0.299835840033294 0.372034622288238 no 1245 0.382151187963554 407 17027233 SGTC_2152 5568786 200 µM 0.298307596882398 0.372664374217353 no 1246 0.382734203315708 434 5399883 SGTC_2262 9014885 67.46 µM 0.298172402274299 0.372720101054836 no 1247 0.382785792043723 424 6457424 SGTC_517 1365-0151 113 µM 0.297238613169035 0.373105078989911 no 1248 0.383142172110399 401 768657 SGTC_1872 amphotericin b 148 nM 0.293718672368257 0.37455739905629 no 1249 0.384486442430575 443 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_480 am 92016 50 µM 0.293620048799726 0.374598116680011 no 1250 0.384524127006518 435 2129 K+ channel blocker. SGTC_820 1582-0060 59.9 µM 0.293547459693735 0.374628086636033 no 1251 0.384551864376798 399 3848840 SGTC_2037 5169046 200 µM 0.29201063542016 0.375262774702524 no 1252 0.385139246155301 393 5718022 SGTC_3283 9109332 35.8195 µM 0.291747963794744 0.375371288457438 no 1253 0.385239666957689 402 17027281 SGTC_2664 lyso-paf C-16 73.48 µM 0.290554080268108 0.375864624569314 no 1254 0.385696192063096 420 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2335 9018011 154.17 µM 0.289106174334002 0.376463200021965 no 1255 0.386250064412322 438 6458208 SGTC_1392 3455-1037 33.9 µM 0.28829753366364 0.37679762773061 no 1256 0.386559497450775 435 981132 SGTC_3295 9122362 53.5725 µM 0.287923393812554 0.376952391213763 no 1257 0.386702689581889 412 4730473 SGTC_114 0364-0001 490.298 µM 0.285547839746536 0.377935502900324 no 1258 0.387612229215383 382 4003655 SGTC_2537 larixol 68.93 µM 0.284210594516828 0.37848926385518 no 1259 0.388124498427783 425 6708759 SGTC_995 3931-2021 34.6 µM 0.283035043398524 0.378976272569973 no 1260 0.388574987047644 417 730143 SGTC_733 4069-0007 56.1 µM 0.282965980667551 0.379004889944733 no 1261 0.38860145757815 417 5717425 YNL287W SEC21 SGTC_462 ag-879 158 µM 0.282799975031107 0.379073680054739 no 1262 0.388665086735769 439 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_585 0kpi-0023 191 µM 0.282643940333271 0.379138341857261 no 1263 0.388724896804351 429 64601 SGTC_2107 5363541 170.161 µM 0.282478610492257 0.379206859318188 no 1264 0.388788272696778 447 244052 SGTC_2358 9037157 4 µM 0.282463593202626 0.37921308310475 no 1265 0.388794029421478 406 2388925 SGTC_2206 7254556 146.969 µM 0.282066467217961 0.379377679910803 no 1266 0.388946272471819 411 4398905 SGTC_248 streptozotocin 5.23457 mM 0.281202311682356 0.379735921975929 no 1267 0.389277615853373 429 5300 DNA alkylating agent. SGTC_2406 ethylparaben 405.7 µM 0.280563049012617 0.38000099949852 no 1268 0.389522780336435 376 8434 A possible steroid mimic. SGTC_2046 4110841 106 µM 0.280413278310924 0.380063111777171 no 1269 0.389580225460619 445 44119630 YMR134W ERG29 SGTC_567 1080-0542 68.4 µM 0.279645563009602 0.380381543992347 no 1270 0.389874723447974 415 5950415 SGTC_1749 st037932 54.2 µM 0.279279786067695 0.380533289131872 no 1271 0.390015058875473 430 594497 SGTC_1706 st031321 9.9705 µM 0.279033683606494 0.380635396817538 no 1272 0.390109487587651 407 6103185 SGTC_3023 9089636 49.47 µM 0.277514342498763 0.381265953932386 no 1273 0.390692597211659 413 17249241 SGTC_403 arphamenine a 50 µM 0.277444376219669 0.381294998953065 no 1274 0.390719455580684 450 5487158 An arginine aminopeptidase inhibitor. SGTC_675 1309-0189 238 µM 0.277116629930363 0.381431064791212 no 1275 0.390845276425026 379 4246530 SGTC_1924 st058459 75.1 µM 0.276608795418824 0.381641924277497 no 1276 0.391040255180406 433 688683 SGTC_268 camptothecin 39.6153 µM 0.276009242905975 0.381890911482778 no 1277 0.391270483539265 435 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.274456388714356 0.382536020767247 no 1278 0.391866957002455 419 66535 A nucleotide analog. SGTC_2418 pentamidine 31.67 µM 0.27423485554405 0.382628079921316 no 1279 0.391952071811185 427 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2058 5236698 133 µM 0.273131090402543 0.383086853484269 no 1280 0.392376224160472 396 766665 SGTC_64 000l-0018 272.079 µM 0.272943401244588 0.383164881727201 no 1281 0.39244836165729 399 6811119 SGTC_2958 9077254 16.72 µM 0.272632652753456 0.383294079997052 no 1282 0.392567804587287 395 16457351 SGTC_330 1488-0319 80.1 µM 0.272009225275336 0.383553318299735 no 1283 0.39280746298081 420 6846614 SGTC_102 gallobenzophenone 83.616 µM 0.271298842905709 0.383848778386049 no 1284 0.393080598168069 431 70837 SGTC_1914 st062367 72.6 µM 0.264673535686937 0.386607586572249 no 1285 0.39563048305001 410 978205 SGTC_2190 6049624 200 µM 0.262473698386633 0.387524885334833 no 1286 0.396478130185659 431 2265554 SGTC_2807 7945238 51.95 µM 0.261892646318724 0.38776728032078 no 1287 0.396702104598366 455 17148797 SGTC_413 propylparaben 100 µM 0.261339964651726 0.387997880744061 no 1288 0.396915174885471 410 7175 A pharmaceutical preservative. SGTC_807 1315-0151 48 µM 0.259852832592856 0.3886185663719 no 1289 0.39748864790539 444 4011080 SGTC_2908 7930301 100 µM 0.258918580533769 0.389008641583433 no 1290 0.397849030861439 400 2223178 SGTC_1481 3346-2004 36 µM 0.25828102425669 0.389274902639973 no 1291 0.398095015004068 447 2770522 SGTC_530 4358-1714 28 µM 0.257579034387631 0.389568133080983 no 1292 0.398365905988912 448 1564641 SGTC_3219 9131112 49.47 µM 0.257329619182821 0.389672332254699 no 1293 0.398462164663638 411 17612988 YMR079W SEC14 SGTC_2368 9071271 200 µM 0.25601205916823 0.39022290593741 no 1294 0.398970762841657 432 27209959 SGTC_1364 1653-0028 37.6 µM 0.255077549873452 0.390613546381927 no 1295 0.399331601681754 461 5718652 SGTC_1682 st012968 530 nM 0.254959051809938 0.390663088443044 no 1296 0.399377363080708 405 24207270 SGTC_236 1509-0011 5.31 µM 0.25441970000037 0.390888604839909 no 1297 0.39958566658726 451 3107280 SGTC_871 0574-0004 149 µM 0.254122627791928 0.391012833792376 no 1298 0.399700411301691 425 9551173 SGTC_475 α-linolenic acid 10 µM 0.254094687959328 0.391024518177775 no 1299 0.399711203561838 419 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2048 5246248 200 µM 0.253503362878571 0.391271832269423 no 1300 0.399939631410282 437 677046 SGTC_1323 1348-1351 11.2 µM 0.252555537360049 0.391668339750863 no 1301 0.400305846161602 454 6989654 SGTC_272 doxorubicin 8.13 µM 0.251985653009694 0.391906795869425 no 1302 0.400526076650263 437 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2551 apiole 73.87 µM 0.250908851533417 0.392357471587933 no 1303 0.400942290375565 438 10659 A possible DNA adduct former. SGTC_258 haloperidol 50.781 µM 0.250708010628791 0.392441545901173 no 1304 0.401019933430583 445 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2624 nerol 100 µM 0.250694412103805 0.392447238581678 no 1305 0.401025190623656 430 637566 A natural product oil. SGTC_2954 9074818 52.69 µM 0.250671785679523 0.39245671061619 no 1306 0.401033938044516 447 16648742 SGTC_2862 9027634 71.43 µM 0.249140170842734 0.393098033941923 no 1307 0.401626178532942 426 5012562 SGTC_858 0438-0351 2.77 µM 0.248870758508025 0.393210873319326 no 1308 0.401730377545413 416 2799119 SGTC_1405 3909-7894 12 µM 0.247507113698598 0.393782153256719 no 1309 0.40225789339997 437 7104060 SGTC_801 0866-0028 10.1 µM 0.247497554716482 0.393786158667231 no 1310 0.402261591850708 440 6849771 SGTC_2075 5212009 200 µM 0.247115831304132 0.393946117824005 no 1311 0.402409291003838 471 780898 SGTC_2324 6149169 200 µM 0.246601440501837 0.394161698840304 no 1312 0.402608344806973 459 2888231 SGTC_492 tmb-8 126 µM 0.245912881814476 0.394450324309576 no 1313 0.402874835869754 449 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_577 r071-0003 38.6 µM 0.242146660944991 0.396030045366111 no 1314 0.404333261798503 434 4568517 YMR134W ERG29 SGTC_2127 5253358 187.912 µM 0.241895475033294 0.396135465019708 no 1315 0.404430578216876 436 20612 SGTC_2435 5706476 10.6 µM 0.241448675304224 0.396323000166559 no 1316 0.404603695486477 437 5725375 SGTC_633 0437-0093 97.7 µM 0.24081810645813 0.396587709496081 no 1317 0.404848047811154 430 2831118 SGTC_1417 3966-0327 90.4 µM 0.238257191538245 0.397663256197121 no 1318 0.405840810777311 452 651118 SGTC_119 0121-0043 24.815 µM 0.237835230846625 0.397840548408472 no 1319 0.406004446151156 453 1092378 SGTC_1816 st051957 91.6 µM 0.23755754712782 0.397957232307916 no 1320 0.406112140212398 464 674121 SGTC_2017 5132927 60.65 µM 0.237154194011981 0.398126739287586 no 1321 0.406268585281468 426 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1065 prochlorperazine maleate 2.48 µM 0.236894966090881 0.398235688580464 no 1322 0.406369137664644 469 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1384 3089-0840 101 µM 0.236281977624962 0.398493349243748 no 1323 0.406606935413929 413 1069836 SGTC_1737 st035557 69.7 µM 0.236243675595242 0.398509450407383 no 1324 0.406621795135395 449 5716916 SGTC_2174 5790901 200 µM 0.236223338472507 0.398517999667906 no 1325 0.406629685215236 433 786020 SGTC_334 1502-1024 68.5 µM 0.236205689194566 0.398525419059523 no 1326 0.406636532537676 446 3296216 SGTC_2740 felodipine 17.08 µM 0.234425174111723 0.399274098849353 no 1327 0.407327458477412 459 3333 L-type calcium channel blocker SGTC_1478 0453-0656 35.7 µM 0.234375332930354 0.39929506166111 no 1328 0.407346803425501 444 5258496 SGTC_148 3253-0744 288.01 µM 0.23407350881121 0.39942201273071 no 1329 0.407463955794224 424 6893655 SGTC_1773 st048542 73.5835 µM 0.232221638966909 0.400201165124323 no 1330 0.408182935815379 443 3237138 SGTC_3235 9132602 49.47 µM 0.231867552261952 0.400350188280032 no 1331 0.408320443654473 439 4912240 SGTC_2894 9048625 32.47 µM 0.231692449522248 0.400423888482263 no 1332 0.408388448119614 467 4092861 SGTC_1550 gossypolone 36.6 µM 0.23082879564791 0.400787449554063 no 1333 0.408723904783637 423 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3164 9100705 49.47 µM 0.230479464511325 0.400934527343956 no 1334 0.408859609467956 457 17174235 SGTC_1310 1188-0297 994 nM 0.230254706831321 0.401029163788427 no 1335 0.408946926872856 440 1588352 SGTC_2176 5809774 33.9695 µM 0.228197239991677 0.401895749804164 no 1336 0.409746453504297 465 2870539 SGTC_432 NS 1619 61.3 µM 0.228136595901322 0.401921299876493 no 1337 0.409770025363351 402 4552 A K+/calcium channel activator. SGTC_1469 k284-2957 126 µM 0.227088257076897 0.402363043582586 no 1338 0.410177557516666 443 23884841 SGTC_1620 st003704 16.5 µM 0.226804656497573 0.40248256721504 no 1339 0.410287821347246 452 2834414 SGTC_282 k297-0036 65.7 µM 0.22515283597101 0.403178908803068 no 1340 0.41093018942557 436 5061378 SGTC_2024 5144227 134 µM 0.223104870141858 0.404042675690611 no 1341 0.411726944028543 438 3475211 SGTC_2205 7238770 200 µM 0.222737571730065 0.404197640108584 no 1342 0.411869878910397 449 279867 SGTC_1434 4073-0095 163 µM 0.220872918864918 0.404984574738539 no 1343 0.412595692144984 456 24133745 SGTC_3336 9143619 71.43 µM 0.2205922097294 0.405103075055092 no 1344 0.412704983692523 463 45595730 SGTC_1588 farnesol 29.9 µM 0.219730766993816 0.405466784178232 no 1345 0.413040420800103 431 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.21948900567716 0.405568872736152 no 1346 0.413134571638317 416 5379071 SGTC_596 1155-0152 116 µM 0.219429651057024 0.405593937395658 no 1347 0.413157687296513 463 280313 SGTC_617 3770-0098 35 µM 0.21815523642234 0.406132198813304 no 1348 0.413654080607286 433 5962639 SGTC_327 1273-0057 3.96 µM 0.215526781077751 0.40724291190151 no 1349 0.414678317185276 458 3108138 SGTC_857 0438-0306 1.35 µM 0.215430201643415 0.407283737988275 no 1350 0.414715962624087 409 4686136 SGTC_3088 9117578 49.47 µM 0.214836948262263 0.407534540311481 no 1351 0.414947222439367 438 678341 SGTC_3224 9130643 49.47 µM 0.214183114591242 0.407810997313661 no 1352 0.415202131578991 417 17644395 SGTC_3118 9124250 49.47 µM 0.214086617546658 0.407851802535207 no 1353 0.415239755760834 466 1504786 SGTC_1943 st076331 65.2 µM 0.213940432086049 0.407913621152211 no 1354 0.415296754928494 460 24208415 SGTC_602 3130-1533 38.1 µM 0.213877629285951 0.407940179779588 no 1355 0.415321242913516 463 720941 SGTC_533 1222-0222 6.71 µM 0.213087046845509 0.40827454471417 no 1356 0.415629533878273 463 3982874 SGTC_1246 0422-0085 105 µM 0.209456111150642 0.409811048552086 no 1357 0.417046096834457 479 264295 SGTC_183 3914-0051 30.55 µM 0.209040597200905 0.409986970503404 no 1358 0.417208273328268 461 1596232 SGTC_2714 st079313 56.9 µM 0.208263397082057 0.410316073202236 no 1359 0.417511654948329 439 2939799 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.208109852547105 0.410381098583669 no 1360 0.417571597179548 431 16725076 SGTC_729 4092-0585 94.1 µM 0.207477342952491 0.410648989354112 no 1361 0.417818542700919 418 2169061 SGTC_1306 1185-0270 9.02 µM 0.207216043714526 0.410759671240802 no 1362 0.417920569079629 455 1548076 SGTC_845 0330-0138 4.51 µM 0.206157053784542 0.411208313929458 no 1363 0.418334116667722 478 9039800 SGTC_3103 9120822 49.47 µM 0.205727133613968 0.411390483443041 no 1364 0.418502031168861 483 17141819 SGTC_3093 9117344 49.47 µM 0.205547300058469 0.411466689750782 no 1365 0.418572273410615 421 24824913 SGTC_1559 coumarin 343 70.1 µM 0.20442059466243 0.411944218591906 no 1366 0.419012418878537 437 108770 A hepatotoxic, DNA x-linker. SGTC_896 0964-0007 44.5 µM 0.203330591449521 0.412406316169771 no 1367 0.419438323195711 446 6756758 SGTC_1086 cerivastatin 2.18 µM 0.202945204383481 0.41256972682795 no 1368 0.419588930701545 452 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2251 lansoprazole 556 µM 0.202900931491514 0.412588500256737 no 1369 0.419606233100352 467 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1091 telmisartan 47.6 µM 0.202023698208858 0.412960522481484 no 1370 0.419949098825732 451 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1338 1486-1223 76 µM 0.201719339637348 0.413089614931146 no 1371 0.420068071272423 474 3444526 SGTC_2828 7998861 71.43 µM 0.20151016707207 0.413178340073272 no 1372 0.420149840157494 465 2988188 SGTC_3313 9133968 57.047 µM 0.201179842661359 0.413318463463389 no 1373 0.420278976245137 475 1494643 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.198688558936459 0.41437561878014 no 1374 0.421253187120784 468 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_229 benomyl 22.8748 µM 0.196252046662927 0.415410132675296 no 1375 0.422206446338503 440 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_865 0488-0499 301 µM 0.19624450175392 0.415413337067995 no 1376 0.422209398913903 467 9634651 SGTC_1540 guanosine 70.6 µM 0.195603023374622 0.415685799425054 no 1377 0.422460446842144 468 6802 Guanosine is a purine nucleoside SGTC_479 n-linoleoylglycine 10 µM 0.19559687134086 0.415688412644298 no 1378 0.422462854644672 462 6433346 An anti-infammatory. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.194618284588074 0.416104137490508 no 1379 0.422845893864961 447 2374 Ca(2+)-ATPase inhibitor. SGTC_1401 3807-4679 7.6 µM 0.194543194104211 0.416136041438708 no 1380 0.422875288861449 453 3291456 SGTC_1356 1502-0781 85.8 µM 0.194140048511091 0.416307336715032 no 1381 0.423033111979096 430 567702 SGTC_962 1254-0300 21.5 µM 0.193921605533599 0.416400159081887 no 1382 0.423118633024597 446 7340576 SGTC_1826 st055655 41.6 µM 0.192652227056213 0.416939644654455 no 1383 0.423615669869488 466 676168 SGTC_1211 1056-0033 32.3 µM 0.192642413740017 0.416943815922372 no 1384 0.423619512838433 468 6741922 SGTC_1164 k060-0068 93.7 µM 0.191197890900365 0.417557929449578 no 1385 0.424185277976605 461 5963676 SGTC_1333 1482-0047 286 µM 0.190346386202052 0.417920026047285 no 1386 0.424518853551492 485 3811116 SGTC_2729 fluphenazine 10.66 µM 0.190342695167754 0.417921595786291 no 1387 0.424520299626016 468 3372 An atypical antipsychotic. SGTC_1612 st002233 45.4 µM 0.188907384646254 0.418532109726691 no 1388 0.425082702838309 471 1035021 SGTC_3186 9110464 49.47 µM 0.188802325106585 0.418576804866989 no 1389 0.425123874723377 459 17018021 SGTC_109 0132-0036 33.701 µM 0.188407417267897 0.418744818629378 no 1390 0.425278642840733 488 67274 A color developer. SGTC_118 0083-0097 135.343 µM 0.187087560743481 0.419306459719691 no 1391 0.425795990525573 469 5207356 SGTC_3325 9138760 55.175 µM 0.185844801676108 0.419835443732595 no 1392 0.426283234916914 430 43844959 SGTC_2533 agelasine 13.65 µM 0.184749395042167 0.420301826915155 no 1393 0.426712800677657 475 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_742 0kpi-0133 140 µM 0.184476655934351 0.420417966455992 no 1394 0.426819769366975 476 2728852 SGTC_1182 1222-0449 220 µM 0.18397995217029 0.420629493875684 no 1395 0.427014591153042 482 658318 SGTC_2155 5570423 76 µM 0.183025901666501 0.421035852283362 no 1396 0.427388847647752 464 797402 SGTC_682 0kpi-0099 17 µM 0.18088060604008 0.421949904000206 no 1397 0.428230645942934 470 1714895 YML126C ERG13 SGTC_2543 pimpinellin 60.67 µM 0.180624769878884 0.422058936949238 no 1398 0.428331056057143 471 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1115 galangin 695.678 nM 0.178872080493181 0.42280606309557 no 1399 0.429019072869257 489 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1835 st008666 49.2 µM 0.178605391918692 0.422919769949167 no 1400 0.429123780216115 444 690455 SGTC_3129 9127257 49.47 µM 0.176357303040368 0.423878532199031 no 1401 0.430006623051465 469 837894 SGTC_1419 3993-2473 62.6 µM 0.17626773837743 0.423916739003477 no 1402 0.430041803105291 470 704026 SGTC_802 4112-3352 742 µM 0.176201707278007 0.423944907236813 no 1403 0.430067739779565 422 704594 SGTC_3075 9116269 49.47 µM 0.176111625973838 0.423983335683315 no 1404 0.430103123736485 471 17015205 YNL244C SUI1 SGTC_949 1165-0505 146 µM 0.175983140646 0.424038148435586 no 1405 0.430153593773972 446 6244267 SGTC_2798 7813637 45.45 µM 0.1758047907075 0.424114236219887 no 1406 0.430223652910217 485 956368 SGTC_316 k060-0003 58.6 µM 0.1752214260543 0.424363131428287 no 1407 0.430452824608197 458 6152314 SGTC_560 2332-1943 155 µM 0.174872617429639 0.424511966647317 no 1408 0.430589863415454 490 21177716 SGTC_2496 diffractaic acid 79.83 µM 0.174388977323021 0.424718351715875 no 1409 0.430779888207558 445 94870 An apoptosis inducer which activates caspases. SGTC_1207 2099-0101 141 µM 0.174284476574617 0.4247629483202 no 1410 0.430820949219318 464 5837381 SGTC_2827 7993847 71.43 µM 0.173824990431329 0.424959049451842 no 1411 0.431001501922297 475 2985692 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.173343813696772 0.425164427677337 no 1412 0.431190593288866 453 6708739 YPR165W RHO1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.171760629388849 0.425840313271372 no 1413 0.431812859325861 470 2333 A French combination drug. SGTC_2502 avocadyne acetate 18.59 µM 0.171332272609803 0.426023222874714 no 1414 0.431981252877844 453 3952079 SGTC_1096 rimcazole 32.2 µM 0.170714377643604 0.426287093869839 no 1415 0.432224178532325 487 18528119 A dopamine reuptake inhibitor. SGTC_1249 0481-0015 10.2 µM 0.170702057777428 0.426292355383708 no 1416 0.432229022353531 483 4227577 SGTC_611 3453-1652 23.7 µM 0.170654389002031 0.426312713676709 no 1417 0.432247764457058 460 1560575 SGTC_998 3996-0085 177 µM 0.170239409803977 0.426489950519457 no 1418 0.432410929754365 468 715391 SGTC_363 0455-0021 3.06 µM 0.169784518052277 0.426684250994712 no 1419 0.43258980147542 471 4597466 SGTC_1631 benzylvanillin 81.9 µM 0.168496218630851 0.427234625980687 no 1420 0.433096459119469 435 75506 SGTC_351 caspofungin 25 nM 0.166767370669832 0.427973430339575 no 1421 0.433776546767245 450 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1015 4130-4525 82 µM 0.166590020129772 0.428049233490178 no 1422 0.433846323373395 450 1363237 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.166354312590048 0.428149983693148 no 1423 0.433939063085213 449 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.165848530504798 0.428366189641054 no 1424 0.434138076559074 452 75037 A free radical scavenger. SGTC_1315 1237-0019 3.69 µM 0.16531288940891 0.428595182821468 no 1425 0.434348857059355 482 825140 SGTC_1570 verbenone 133 µM 0.165262076641767 0.42861690715636 no 1426 0.434368853396927 482 29025 A natural terpanoid with antifungal properties. SGTC_3226 9131256 49.47 µM 0.163944091174629 0.429180470004155 no 1427 0.434887578459018 452 17178073 SGTC_2964 9083345 53.42 µM 0.163370236423921 0.42942589211373 no 1428 0.435113467957869 482 17741579 SGTC_417 st075190 100 µM 0.160621001020011 0.430602042306569 no 1429 0.436195956620983 487 222757 SGTC_457 grayanotoxin iii 135 µM 0.159914864375739 0.430904234396434 no 1430 0.436474069565749 481 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2386 9075165 157.42 µM 0.159745160400301 0.430976865468903 no 1431 0.436540912409431 465 16452277 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.159277084384115 0.431177207947663 no 1432 0.436725287140649 480 676296 Flavone; oxidizing agent. SGTC_1934 st074720 32.6 µM 0.159053699404026 0.431272825801324 no 1433 0.436813283135897 457 17250992 SGTC_3244 9134489 49.47 µM 0.158614525810507 0.431460821693325 no 1434 0.436986291871085 482 16584271 SGTC_8 0354-0001 70 µM 0.158067805485905 0.431694876524135 no 1435 0.437201684571228 480 4993152 SGTC_1900 st060200 72.8 µM 0.158044332717195 0.431704925919628 no 1436 0.437210932610673 449 688945 SGTC_2980 9014342 25.29 µM 0.157690393313255 0.431856463336309 no 1437 0.437350385402302 479 2996599 SGTC_1124 fisetin 1.16336 µM 0.155745102984548 0.4326895082577 no 1438 0.438116971947001 451 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2767 sibutramine 71.45 µM 0.155455278236325 0.432813647586914 no 1439 0.43823120402804 485 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_189 3970-0742 2.116 µM 0.155223413005969 0.432912966152026 no 1440 0.438322595540047 491 2891807 SGTC_1814 st052110 31.539 µM 0.154282158424518 0.433316192330267 no 1441 0.438693632197521 475 674163 SGTC_2713 st079149 53.4 µM 0.153661245023963 0.433582224857051 no 1442 0.438938421886424 473 3103253 SGTC_2947 9072639 7.68 µM 0.152816728369481 0.433944109261826 no 1443 0.439271402676688 449 16488146 SGTC_2627 acetyl isogambogic acid 100 µM 0.152526334451062 0.434068558965984 no 1444 0.439385910770151 470 6857789 A caspase activator and apoptosis inducer. SGTC_1054 3429-0080 167 µM 0.150348286768003 0.43500217921951 no 1445 0.440244919290151 481 1162877 SGTC_993 3909-8757 62.7 µM 0.150192338406946 0.435069040461061 no 1446 0.440306435198639 455 4288324 YLR208W SEC13 SGTC_367 0335-0881 7.1 µM 0.149879670547791 0.435203099152162 no 1447 0.440429775539822 491 23828853 SGTC_2401 5128683 200 µM 0.146519497157345 0.436644265735773 no 1448 0.441755649752851 477 708373 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.145174409267283 0.437221406094464 no 1449 0.442286585155619 478 688803 SGTC_2588 indole-3-carbinol 100 µM 0.144633569290739 0.437453503442957 no 1450 0.442500095720344 486 3712 Induces cell cycle arrest. SGTC_2105 5350118 200 µM 0.143778990878962 0.437820283091454 no 1451 0.442837496666066 463 2133313 SGTC_2338 7999974 200 µM 0.143634148403432 0.43788245386965 no 1452 0.442894686860236 492 315925 SGTC_3020 9089140 49.47 µM 0.143351810580883 0.438003646222222 no 1453 0.443006169697395 463 17217859 SGTC_2244 6635614 200 µM 0.142479354200875 0.438378181245336 no 1454 0.443350692976734 458 836499 SGTC_1525 8-methoxypsoralen 92.5 µM 0.14089650173303 0.439057821443541 no 1455 0.443975852895947 502 4114 Related to psoralen; DNA damaging agent. SGTC_204 PMA1.184 62.41 µM 0.139229383847677 0.43977383754071 no 1456 0.444634444839124 468 2252213 YGL008C PMA1 SGTC_3150 9097574 49.47 µM 0.136135722973973 0.441103064778535 no 1457 0.445856993775397 484 17217476 SGTC_2635 hydroquinidine 100 µM 0.135783465300773 0.441254458740886 no 1458 0.445996231384262 480 442912 An experimental heart treatment. SGTC_1112 tnp00069 1.16933 µM 0.135435875811982 0.441403854816963 no 1459 0.446133630318625 501 145826 SGTC_1202 1988-0068 29.6 µM 0.135352048074616 0.441439885736908 no 1460 0.446166767622451 486 2850480 SGTC_2717 st081029 62.2815 µM 0.135308701669096 0.441458517121375 no 1461 0.44618390270707 502 5292846 SGTC_1068 loratadine 26.9 µM 0.133407441884351 0.442275853679707 no 1462 0.446935580122605 482 3957 A H1 histamine antagonist. SGTC_3124 9127567 49.47 µM 0.132943624742257 0.442475282430444 no 1463 0.447118982767448 479 17592030 SGTC_3200 9114385 49.47 µM 0.132523782071561 0.442655815926786 no 1464 0.447285006772905 465 17018030 YLR208W SEC13 SGTC_2526 patulin 37.61 µM 0.131835950726373 0.442951611003998 no 1465 0.447557025077126 460 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_233 rapamycin 362 pM 0.13083728926731 0.44338113205888 no 1466 0.447952011982531 492 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1833 st055984 71 µM 0.129705427723991 0.443868022448931 no 1467 0.448399744072748 455 676288 SGTC_2036 5160441 105 µM 0.129152670273194 0.444105831747997 no 1468 0.448618423053711 473 134534 YIL048W NEO1 SGTC_2854 9024559 71.43 µM 0.127612128527358 0.444768715104429 no 1469 0.449227966218162 473 3163529 SGTC_2199 6590217 200 µM 0.127550311028355 0.444795317938878 no 1470 0.449252427938552 476 703109 SGTC_2907 7721985 69.9 µM 0.127136278278652 0.444973501151648 no 1471 0.449416269255311 472 3267881 SGTC_485 niflumic acid 177 µM 0.126012487310632 0.445457191989914 no 1472 0.449861019963766 478 4488 A COX2 inhibitor. SGTC_422 cantharidin 155 µM 0.12484277875493 0.445960732452778 no 1473 0.450324009875154 504 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1154 4088-0362 150 µM 0.124766376628581 0.445993625364112 no 1474 0.450354253454316 491 6618304 SGTC_2782 7736369 71.43 µM 0.121361601265016 0.447459835245601 no 1475 0.451702314885176 487 2950836 YOL077C BRX1 SGTC_416 estradiol valerate 100 µM 0.121292772109147 0.447489482851046 no 1476 0.451729572386354 484 13791 A steroid. SGTC_894 0960-0238 55.9 µM 0.119559531267863 0.448236158690007 no 1477 0.452416039533245 507 6741907 YDL195W SEC31 SGTC_3319 9138450 16.7555 µM 0.119319530997076 0.448339564726786 no 1478 0.452511105269725 504 2029690 SGTC_1991 st073000 8.92 µM 0.119206231819459 0.448388381804 no 1479 0.452555984789384 490 4301969 YIL048W NEO1 SGTC_2853 9015042 58.44 µM 0.118823618842031 0.448553243558437 no 1480 0.452707548059158 496 6457456 SGTC_1615 st002656 86.5 µM 0.117927141851087 0.448939555766509 no 1481 0.453062693605706 468 1584458 SGTC_1403 3909-7815 62.9 µM 0.117526735791425 0.449112115454589 no 1482 0.453221329376623 502 6615483 SGTC_11 0438-0307 1.3 µM 0.11751192186702 0.449118499873924 no 1483 0.453227198607781 489 4011476 SGTC_1825 st052143 62.6 µM 0.116932318373833 0.449368304355112 no 1484 0.453456843731633 484 674173 SGTC_2750 bromebric acid 70.15 µM 0.116194982501752 0.449686119224723 no 1485 0.453749006601201 480 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2606 farnesol 9.78 µM 0.116185662441948 0.449690136669592 no 1486 0.453752699753654 511 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1986 st071812 45 µM 0.11573952929547 0.449882449970099 no 1487 0.453929488454508 508 11838594 SGTC_15 0266-0086 27.098 µM 0.115426780372459 0.450017272747273 no 1488 0.454053426577839 504 1712902 YIL048W NEO1 SGTC_2651 TUB2.036 5 µM 0.114587991016471 0.450378894474989 no 1489 0.454385849392856 472 15992207 YFL037W TUB2 SGTC_772 k072-0172 35.3 µM 0.114349621013352 0.450481668894589 no 1490 0.45448032427598 455 5861980 SGTC_2179 6298986 200 µM 0.113919355642518 0.450667188363855 no 1491 0.454650860934275 502 738374 SGTC_2434 5670830 169.91 µM 0.113913683610717 0.450669634071575 no 1492 0.454653109112872 488 1549830 SGTC_746 1095-0025 46.6 µM 0.113817379683825 0.45071115938152 no 1493 0.454691280563958 510 6749286 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.113808785067403 0.450714865322164 no 1494 0.454694687184538 507 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1738 st035555 74 µM 0.112983269102343 0.451070842218454 no 1495 0.455021909797325 501 5331140 SGTC_1186 1319-0216 26 µM 0.112560515109289 0.451253156376794 no 1496 0.455189495209173 483 4565136 SGTC_3232 9132874 49.47 µM 0.112272959421257 0.451377171665316 no 1497 0.455303490739614 507 3784940 SGTC_691 1548-0686 185 µM 0.112161266341565 0.451425343265641 no 1498 0.455347770153704 503 46495133 SGTC_1629 st005085 44.9 µM 0.112147713258515 0.451431188561864 no 1499 0.455353143152592 509 24207091 SGTC_501 nsc-95397 161 µM 0.111741912192465 0.45160621098793 no 1500 0.455514023144295 498 262093 SGTC_1183 1254-0324 198 µM 0.111343619587014 0.45177800415498 no 1501 0.455671933498048 481 5799357 SGTC_331 k048-0133 24.5 µM 0.110916848969668 0.451962090593768 no 1502 0.455841142249404 501 6813582 SGTC_1004 4084-0029 199 µM 0.110451452846225 0.452162849820015 no 1503 0.456025674618171 499 716894 YLR208W SEC13 SGTC_3246 9135460 32.98 µM 0.110394741775067 0.452187314270366 no 1504 0.45604816154896 505 41446951 SGTC_1864 st057645 30.4 µM 0.109783414751037 0.452451044647906 no 1505 0.456290572321013 498 688666 SGTC_1438 4092-1045 4 µM 0.109718567479066 0.45247902140746 no 1506 0.456316287300197 499 1351342 SGTC_1357 1503-1303 39.5 µM 0.109412870302232 0.452610910106354 no 1507 0.456437513004558 494 292895 SGTC_1653 st012112 65 µM 0.109348705620594 0.452638593710012 no 1508 0.456462958336803 500 720429 SGTC_1075 aripiprazole 15.2 µM 0.108876843307498 0.452842183942655 no 1509 0.456650086901493 482 60795 An atypical antipschotic. YIL048W NEO1 SGTC_634 1611-4317 11.2 µM 0.107746391486983 0.453329980256814 no 1510 0.457098434303984 488 2843522 SGTC_1513 0337-0559 19 µM 0.106321067612448 0.453945115807386 no 1511 0.457663808395395 502 775073 SGTC_320 4092-0846 5.34 µM 0.105483826715317 0.454306500479679 no 1512 0.45799595140003 504 1359356 SGTC_1145 3546-0597 10.2 µM 0.104782194899369 0.454609380317552 no 1513 0.458274319338772 493 875334 SGTC_2591 skatole 100 µM 0.104203250721256 0.454859318339611 no 1514 0.458504027158075 498 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_224 benfluorex 43.875 µM 0.104035794620507 0.454931614736864 no 1515 0.458570471342281 514 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2921 7974240 10.71 µM 0.103172971428865 0.455304147965233 no 1516 0.458912845543897 492 2979074 YDR527W RBA50 SGTC_592 k241-0073 46.5 µM 0.102460463526674 0.455611810590649 no 1517 0.459195596588674 503 4230158 SGTC_2314 7727897 200 µM 0.102192792673953 0.45572739839739 no 1518 0.459301824209559 503 900724 SGTC_1448 4255-0083 152 µM 0.10207642465915 0.455777650550186 no 1519 0.459348006824981 497 5399660 SGTC_1496 4469-0713 57.4 µM 0.100568836567377 0.456428748328668 no 1520 0.459946368032704 511 746691 SGTC_921 1561-0023 372 µM 0.100235168494554 0.456572868911327 no 1521 0.460078813088481 512 24050882 SGTC_3106 9121286 49.47 µM 0.0973846988110402 0.457804297511053 no 1522 0.461210447774304 473 15943471 SGTC_2880 9042983 58.44 µM 0.0966428597734233 0.458124845585358 no 1523 0.461505009299866 494 6464714 SGTC_2890 9046729 58.44 µM 0.094521328174219 0.459041707367491 no 1524 0.462347520429093 496 903329 SGTC_2946 9065502 71.43 µM 0.0943374710310877 0.45912117519365 no 1525 0.462420542524319 488 16489101 SGTC_1042 0350-0096 82 µM 0.0920412614807646 0.460113793098543 no 1526 0.463332628393876 460 3122515 SGTC_2832 7992762 51.95 µM 0.0913664847134035 0.46040553680059 no 1527 0.463600695828065 495 2985177 SGTC_2001 4023502 57.655 µM 0.0913276769409058 0.460422316218874 no 1528 0.463616113430482 500 108941 YCR052W RSC6 SGTC_2611 pyromycin 23.93 µM 0.0904184404509085 0.460815465287946 no 1529 0.46397735167638 497 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_903 1134-0042 114 µM 0.0904013906298137 0.460822837907851 no 1530 0.463984125828435 487 701009 SGTC_2540 epiandrosterone 100 µM 0.0898326345259761 0.461068784998019 no 1531 0.464210107210962 513 441302 A steroid. SGTC_2023 5144124 124 µM 0.0892310848492224 0.461328929209251 no 1532 0.464449130883431 519 2830192 SGTC_3145 9085516 49.47 µM 0.0885430929390746 0.461626476226302 no 1533 0.46472251780019 501 25236195 SGTC_1111 tnp00062 510.699 nM 0.088336591623366 0.461715789397478 no 1534 0.464804578354837 487 676306 SGTC_2905 7799065 20.05 µM 0.0862949901710005 0.46259889858235 no 1535 0.465615960443007 512 1296806 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.086207581969597 0.462636711766668 no 1536 0.465650701804123 508 551469 SGTC_2299 7976368 114.88 µM 0.0861490796130261 0.462662020340066 no 1537 0.465673954362204 496 2979718 SGTC_158 k038-0087 26.446 µM 0.0859044393091486 0.462767855270232 no 1538 0.465771191250333 468 X158 SGTC_833 3852-0053 558 µM 0.0849105905151298 0.463197835643341 no 1539 0.466166236091552 493 3123681 SGTC_3322 9139058 2.11 µM 0.0843533055096788 0.463438959190294 no 1540 0.466387765856431 478 4908926 YPR165W RHO1 SGTC_321 4534-3890 65.3 µM 0.0831346861631027 0.463966272556811 no 1541 0.466872222863498 517 699746 SGTC_3095 9117207 49.47 µM 0.082991023964181 0.464028441357241 no 1542 0.466929338415847 521 17015229 SGTC_3180 9109287 49.47 µM 0.0821192868500895 0.46440569820734 no 1543 0.467275928116786 504 18891271 SGTC_1782 st039423 80.636 µM 0.0820606930123949 0.464431056690025 no 1544 0.467299225047332 492 2068169 SGTC_747 3448-8087 38.7 µM 0.0810891856141811 0.464851530647344 no 1545 0.467685512997561 505 5168703 SGTC_2097 5376186 200 µM 0.0797322143261677 0.465438901178965 no 1546 0.468225118839887 490 742755 SGTC_496 calpeptin 138 µM 0.0794275741970442 0.465570776291739 no 1547 0.468346268441469 509 73364 A calpain inhibitor. SGTC_3249 9135183 49.47 µM 0.0791284055854624 0.465700286529041 no 1548 0.46846524497733 510 4902779 SGTC_27 0485-0001 32.618 µM 0.0780736410796156 0.466156923486278 no 1549 0.468884737274614 517 2054479 SGTC_2557 derrustone 83.84 µM 0.0773546735956693 0.466468210125963 no 1550 0.469170698959513 509 629853 An antioxidant. SGTC_3342 9147791 14.508 µM 0.0770846030514169 0.466585146109787 no 1551 0.469278120768794 513 1838168 SGTC_17 0960-0276 49.807 µM 0.076945530882579 0.466645363135524 no 1552 0.469333438240594 505 6821114 SGTC_2123 5259487 200 µM 0.0769266572468594 0.466653535312635 no 1553 0.46934094548067 517 2173474 SGTC_1449 4112-4002 201 µM 0.0763657935565414 0.466896392507478 no 1554 0.469564041449318 503 2059539 SGTC_2737 bleomycin 30.5 nM 0.0748214906690948 0.467565147930599 no 1555 0.470178371331091 520 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_834 0312-0008 75.7 µM 0.0743798258277299 0.467756426396298 no 1556 0.470354080494331 513 6385573 YIL048W NEO1 SGTC_344 k064-0035 6.43 µM 0.0743046219955013 0.467788996799117 no 1557 0.470383999690106 513 5088750 SGTC_1567 st069303 68.4 µM 0.0739923729818511 0.467924232585906 no 1558 0.470508227052339 520 5581319 SGTC_2020 4017018 200 µM 0.0736822607385877 0.468058546596432 no 1559 0.470631607147507 506 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_298 1391-0729 10 µM 0.0731396279621037 0.46829357728626 no 1560 0.470847503766203 505 3237558 SGTC_1102 cgs 12066b 26.1 µM 0.0710132895956041 0.469214664570148 no 1561 0.471693589313361 512 6438352 A 5-HT1B full agonist. SGTC_477 mead ethanolamide 10 µM 0.0708004404379237 0.469306875725878 no 1562 0.471778290643706 502 16061185 SGTC_347 4534-1311 26.2 µM 0.0697483548073045 0.469762687529194 no 1563 0.472196976948382 518 2862016 SGTC_3135 9127742 49.47 µM 0.0689424025614756 0.470111889885893 no 1564 0.472517733215255 528 3643468 SGTC_1094 duloxetine 25.4 µM 0.0688997164681643 0.470130385526253 no 1565 0.472534722105138 506 60834 A selective serotonin reuptake inhibitor. SGTC_1265 0819-1001 68.8 µM 0.068101680335699 0.470476181844445 no 1566 0.472852346374952 516 3106768 SGTC_2268 7933382 153.85 µM 0.067944542461376 0.470544273747114 no 1567 0.472914890449083 473 935025 YOR257W CDC31 SGTC_3131 9127911 49.47 µM 0.0677814163046973 0.470614961438391 no 1568 0.472979818687945 497 45595681 SGTC_2416 tofa 880 nM 0.067496176593824 0.470738566994838 no 1569 0.473093352861201 482 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1018 4259-0013 28.1 µM 0.06702831241897 0.470941316994705 no 1570 0.473279581913875 500 6801262 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0664353663693311 0.471198282323812 no 1571 0.473515607047836 507 6312947 SGTC_2889 9059656 51.95 µM 0.063755557965096 0.472359780252638 no 1572 0.474582432914771 517 3949838 SGTC_891 0929-0073 133 µM 0.0635493744847896 0.472449155344592 no 1573 0.47466452175681 514 5603632 SGTC_406 estrone 100 µM 0.0632934055854534 0.472560113030076 no 1574 0.47476643340848 525 5870 A steroid. SGTC_1628 st004252 77.7 µM 0.0629990140621751 0.47268772882998 no 1575 0.474883644713829 517 692968 SGTC_2915 7971052 15.16 µM 0.0614565910896506 0.473356399384594 no 1576 0.475497792157814 531 5741558 SGTC_2374 9071832 200 µM 0.0613952200306309 0.473383006505735 no 1577 0.475522229521711 519 17381698 SGTC_2266 7929956 200 µM 0.0610790933720678 0.47352006354417 no 1578 0.475648109565427 526 2967153 SGTC_2320 7373003 200 µM 0.0606278955263337 0.473715686260697 no 1579 0.475827778482946 513 5415828 SGTC_2033 5192550 145 µM 0.0603602299938108 0.473831739145235 no 1580 0.475934366371145 523 182073 SGTC_3007 9078383 71.4286 µM 0.060154276622993 0.473921036737431 no 1581 0.476016380848489 501 6496995 SGTC_2989 9073649 71.4286 µM 0.060068234366509 0.47395834346506 no 1582 0.476050644782521 531 21367202 SGTC_1177 0983-0204 23.6 µM 0.0599464929888544 0.474011129226007 no 1583 0.476099125200514 516 766818 SGTC_2369 9071472 200 µM 0.058830861659035 0.474494876186207 no 1584 0.47654341348733 519 17296037 SGTC_1643 st009866 20.2 µM 0.0585963692952473 0.474596558818894 no 1585 0.476636801299286 523 3156273 YOR207C RET1 SGTC_892 0929-0076 29 µM 0.0585961597760224 0.474596649673197 no 1586 0.476636884741989 522 5751038 SGTC_2487 5918373 44.05 µM 0.0583607852490229 0.474698716502857 no 1587 0.476730625171651 536 2876279 SGTC_837 0091-0265 12.5 µM 0.0569170541269872 0.475324806135219 no 1588 0.477305634553108 519 759367 SGTC_1877 wortmannin 25 µM 0.0553838874148619 0.475989747158444 no 1589 0.477916316057208 521 312145 A covalent inhibitor of PI 3-kinase. SGTC_2569 tetrandrine 100 µM 0.055294728348411 0.476028417905857 no 1590 0.477951830955724 512 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2626 ethyl orsellinate 100 µM 0.0547806134474502 0.476251408118426 no 1591 0.478156622717449 525 75653 A natural product. SGTC_1688 st021091 57.6 µM 0.0540871778907021 0.476552187948462 no 1592 0.478432853927636 533 3656366 SGTC_1670 st016595 4.04 µM 0.0535886576540551 0.476768430916609 no 1593 0.478631446704253 528 597879 SGTC_276 colchicine 750 µM 0.0522242734708912 0.477360294215773 no 1594 0.47917499594421 524 2833 A microtubule depolymerizer. SGTC_1467 k284-1082 293 µM 0.0515416464758693 0.477656433349894 no 1595 0.479446958422606 508 3334705 SGTC_861 0443-0273 110 µM 0.0509749984337229 0.477902267552251 no 1596 0.479672721500091 509 6149169 SGTC_948 3448-0295 75.3 µM 0.0504011263593753 0.47815124439337 no 1597 0.479901369411991 513 678569 SGTC_2115 tiliquinol 12.7705 µM 0.0502460894137199 0.478218509298971 no 1598 0.479963141936639 524 71208 A bioactive hydroxyquinoline. SGTC_2193 5925765 200 µM 0.0501928102084383 0.478241625356389 no 1599 0.479984370478286 503 877370 SGTC_2795 7780010 54.55 µM 0.0501693845844987 0.478251788970875 no 1600 0.47999370419091 522 953673 SGTC_1993 st073995 70.8 µM 0.0474996661599855 0.479410183783608 no 1601 0.481057498201345 526 3098394 SGTC_3033 9090887 49.47 µM 0.0473376008204919 0.479480509874796 no 1602 0.4811220802693 508 19325384 SGTC_1275 0867-0008 21.1 µM 0.0461539844498556 0.479994143631708 no 1603 0.481593759225039 522 3422836 SGTC_3061 glucosamine 200 µM 0.0460981609901542 0.480018369210965 no 1604 0.481616005884598 527 91431 and experimental redox chemotherapeutic SGTC_1201 1889-3372 45.9 µM 0.0455006494565999 0.480277674530655 no 1605 0.481854128622409 509 5392199 SGTC_486 niguldipine 82 µM 0.0449952200116112 0.480497025007413 no 1606 0.482055559487735 523 1236 A calcium channel blocker. SGTC_963 1269-2853 151 µM 0.0441058752573048 0.480883004542198 no 1607 0.482410004782944 515 3668223 SGTC_1041 0206-0046 107 µM 0.0433085217497156 0.481229074720041 no 1608 0.48272779911182 523 50494 SGTC_165 k038-0023 64.381 µM 0.0432352555119256 0.481260874704249 no 1609 0.482757000759587 520 46368543 SGTC_2581 avocatin a 64 µM 0.0431452647402192 0.481299933855629 no 1610 0.482792868413913 525 6710728 A skin care supplement. SGTC_1080 nisoldipine 24.4 µM 0.0424376623483362 0.481607064338626 no 1611 0.483074902583924 533 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0414627712258598 0.482030227701729 no 1612 0.48346348578724 518 6708561 SGTC_2973 9094665 17.96 µM 0.0405899338867485 0.482409110569686 no 1613 0.483811404569679 533 25237061 YIL048W NEO1 SGTC_172 1112-0046 2.638 µM 0.0402337159045722 0.482563742923451 no 1614 0.483953398989057 525 2802135 YIL048W NEO1 SGTC_162 k030-0015 37.8 µM 0.0402180025132969 0.482570564084588 no 1615 0.483959662655473 527 1809920 YMR134W ERG29 SGTC_219 mitoxanthrone 164.414 µM 0.038795571599733 0.483188060239436 no 1616 0.484526687764881 511 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_975 1335-0046 28.5 µM 0.0377758863867194 0.483630744038614 no 1617 0.484933185260841 524 16486740 SGTC_2508 celastrol 40.54 µM 0.0365862590849387 0.484147231572147 no 1618 0.485407449928804 533 122724 Celastrol is a natural product and antioxidant. SGTC_768 0384-0033 77.3 µM 0.0348353289708595 0.484907461976076 no 1619 0.486105524636625 523 3965305 YMR134W ERG29 SGTC_881 0833-0569 170 µM 0.0347448393153535 0.484946752887163 no 1620 0.486141602945836 527 5418700 SGTC_3066 9117245 49.47 µM 0.032983202351924 0.485711690199901 no 1621 0.486843991467297 533 17176980 SGTC_597 k018-0003 82.8 µM 0.0327069576058798 0.485831645926069 no 1622 0.486954137746993 538 6786234 SGTC_1837 st055472 66.5 µM 0.0326829099007875 0.485842088393369 no 1623 0.486963726267065 514 676091 SGTC_2009 4012297 12.05 µM 0.0325687109606369 0.485891678234796 no 1624 0.487009260811718 525 45595307 SGTC_780 0109-0199 192 µM 0.0310920481834296 0.486532924865818 no 1625 0.487598065617822 538 610414 SGTC_355 1311-2252 105 µM 0.0305542460751699 0.486766476288828 no 1626 0.487812515719595 536 5338538 SGTC_1879 gemcitabine 100 µM 0.0289409513559344 0.487467109000685 no 1627 0.488455842414919 532 60750 A nucleoside analog which inhibits DNA replication. SGTC_2803 7707263 71.43 µM 0.0285605935825958 0.487632299102403 no 1628 0.488607520509431 530 2199229 SGTC_1047 2043-3044 82 µM 0.0284740556944137 0.487669882968544 no 1629 0.488642030096769 532 669592 SGTC_2874 9043904 71.43 µM 0.0282780389025908 0.48775501451054 no 1630 0.488720198005832 524 4463428 SGTC_3204 9114183 49.47 µM 0.0278643372100225 0.487934690041188 no 1631 0.488885176087817 536 17027248 SGTC_2641 levomentholum 100 µM 0.027512964073759 0.488087297468454 no 1632 0.489025299963272 537 16666 SGTC_2838 9002687 71.43 µM 0.0258375407471855 0.488814986383266 no 1633 0.489693459324624 524 6457060 SGTC_66 0109-0187 42.4 µM 0.025102239064616 0.489134362872952 no 1634 0.489986707115456 507 759417 SGTC_2790 5423970 71.43 µM 0.0250990549702142 0.489135745891876 no 1635 0.489987976985239 532 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_373 0844-0104 25.9 µM 0.024397062890354 0.489440660969299 no 1636 0.490267945551854 537 5375804 SGTC_661 1304-0007 33.6 µM 0.0228001501491074 0.490134313683191 no 1637 0.49090484412753 528 3117130 SGTC_764 1951-2361 146 µM 0.0226483343361555 0.490200259668149 no 1638 0.490965394238302 525 5438930 SGTC_1664 st014217 9.02 µM 0.0218442682960553 0.490549535527674 no 1639 0.491286090803445 537 3982782 SGTC_157 1348-1695 65.819 µM 0.020270827732394 0.491233038420077 no 1640 0.491913663550583 524 5380510 SGTC_1023 4482-3888 16 µM 0.0195934299273417 0.49152730820527 no 1641 0.492183852493523 541 3303168 SGTC_2286 7945697 125 µM 0.0194861908378667 0.491573894587426 no 1642 0.492226626533973 531 1245733 SGTC_1767 st044992 70.3 µM 0.0190595365984216 0.491759241170866 no 1643 0.492396805339088 541 9600693 SGTC_2074 5212007 75.395 µM 0.0188015323018602 0.491871323929883 no 1644 0.492499715719828 543 758611 SGTC_152 4469-0003 551.229 µM 0.0187171086635479 0.491907999560878 no 1645 0.492533389952899 533 697280 SGTC_2835 9006588 71.43 µM 0.0184892034790365 0.492007007319621 no 1646 0.492624295235233 538 2345538 SGTC_1411 3909-8223 150 µM 0.0183859277430114 0.492051873065929 no 1647 0.492665489290428 536 X1411 SGTC_2390 9097792 176.6 µM 0.0181711726431438 0.492145168755519 no 1648 0.492751149868506 536 4497149 SGTC_2696 st077691 74.316 µM 0.0177587421605765 0.492324341423073 no 1649 0.492915659275563 539 757133 SGTC_1394 3474-0001 65.7 µM 0.0176081348300713 0.492389770333617 no 1650 0.492975733513921 530 5017666 YIL048W NEO1 SGTC_939 1165-0479 45.3 µM 0.0173692531784849 0.492493549009586 no 1651 0.493071018931677 533 1377347 SGTC_542 3381-0244 89.3 µM 0.0169198779760528 0.492688774933346 no 1652 0.493250267352454 544 1112843 SGTC_3217 9129673 49.47 µM 0.0152941729938009 0.493395058180356 no 1653 0.493898745609085 534 17248312 SGTC_3173 9105693 49.47 µM 0.0151749109154353 0.493446872118276 no 1654 0.493946318773587 534 17096658 SGTC_322 k048-0136 19.3 µM 0.0145400870963839 0.493722675976187 no 1655 0.494199548880144 537 6823282 SGTC_2096 5468907 200 µM 0.0138644653149557 0.494016208100803 no 1656 0.494469055787422 541 759785 SGTC_2771 fluoxetine 41.05 µM 0.0136657035815465 0.494102563184412 no 1657 0.49454834273457 542 3386 A selective serotonin reuptake inhibitor. SGTC_1219 1469-0211 33.1 µM 0.0132462239610392 0.494284813441543 no 1658 0.49471567574014 543 6822282 SGTC_3178 9107506 49.47 µM 0.0125373800322801 0.494592785774092 no 1659 0.494998440049121 543 8897194 SGTC_1724 st037281 8.293 µM 0.012444486604397 0.494633145543855 no 1660 0.49503549627413 540 574124 YDL195W SEC31 SGTC_1508 1080-0625 72.9 µM 0.0103915707437127 0.495525097181746 no 1661 0.495854437680265 536 767111 SGTC_2966 9084041 48.03 µM 0.0100532550034014 0.495672090995282 no 1662 0.495989399080793 534 17741380 SGTC_2405 ticlatone 3.52 µM 0.00902151758163424 0.496120371105276 no 1663 0.496400984022687 528 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2188 6126565 140.678 µM 0.00796236004788559 0.496580570084221 no 1664 0.496823511489615 544 874518 SGTC_676 falcarinol 140 µM 0.00604195005748943 0.497414990396375 no 1665 0.497589625331188 543 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.00597976588884887 0.497442009696666 no 1666 0.497614432777071 539 2724 A muscle relaxant with antifungal properties. SGTC_2814 7977482 42.97 µM 0.00503953220457864 0.497850546810157 no 1667 0.497989526040115 545 6456762 SGTC_2634 4'-methoxyflavone 100 µM 0.00472574131641841 0.497986891335396 no 1668 0.498114708999895 544 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2106 5357045 167.29 µM 0.00408757525041236 0.498264180048627 no 1669 0.498369297949325 545 668842 SGTC_1984 st072354 53.1 µM 0.00341890356697633 0.498554724615694 no 1670 0.498636057471683 546 5762938 SGTC_2177 5811945 192 µM 0.00304701097187697 0.498716316027644 no 1671 0.498784420375434 546 5343475 SGTC_1131 3454-3128 32.3 µM 0.00264903062972845 0.498889243084452 no 1672 0.498943190915725 546 710982 SGTC_2146 5545642 200 µM 0.00167381017995093 0.499312988453163 no 1673 0.499332246661652 548 825326 SGTC_1267 0828-0272 9.49 µM 0.000829420374811263 0.499679886929113 no 1674 0.4996691091822 547 745334 SGTC_1636 st007707 68.9 µM 0.00062182118942157 0.499770091558972 no 1675 0.499751929252677 548 403051 SGTC_2458 5808907 16.39 µM 0.00018540853107592 0.499959718743915 no 1676 0.49992603269823 548 2731747 SGTC_439 amiodarone 34.4 µM 0 0.499959718743915 no 1677 0.5 544 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2077 5212015 200 µM -7.76660865766068e-05 0.499925971780098 no 1678 0.499969015714342 548 780900 SGTC_72 0744-0168 198.391 µM -0.000290150222255522 0.499833644556095 no 1679 0.499884246810299 548 677577 SGTC_2877 9040724 71.43 µM -0.00111236168642025 0.499476382709316 no 1680 0.499556231983704 551 6463895 SGTC_1351 1496-0003 46.5 µM -0.00120717640997932 0.499435184468983 no 1681 0.499518406407125 549 3891978 SGTC_2895 9054447 58.44 µM -0.00129971748461533 0.499394974164718 no 1682 0.499481487888794 550 2697450 SGTC_706 4262-0057 46.9 µM -0.00170594538795396 0.499218462919044 no 1683 0.499319426586796 550 883298 SGTC_1214 0358-0031 63.7 µM -0.00222692446542407 0.498992091041879 no 1684 0.499111586409784 552 4301366 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.00279756671103499 0.498744140276644 no 1685 0.498883933812518 554 5024745 SGTC_1215 3852-0577 11.2 µM -0.00289596232263542 0.49870138627285 no 1686 0.498844679801919 551 2884876 SGTC_2421 5690543 90.72 µM -0.00411394644146118 0.498172159815489 no 1687 0.498358777454689 545 3397993 SGTC_333 3486-0131 40.1 µM -0.0043957089976987 0.498049731550174 no 1688 0.498246371475822 550 6744690 SGTC_489 paxilline 115 µM -0.00525812605394602 0.49767500507801 no 1689 0.497902320867472 555 105008 A toxic potassium channel blocker. SGTC_1462 k081-0014 26.5 µM -0.00531469943993059 0.49765042359917 no 1690 0.497879751667224 546 3270634 SGTC_2316 5844804 197.44 µM -0.00535206196761527 0.497634189359494 no 1691 0.49786484638722 550 776813 SGTC_757 1066-0008 322 µM -0.0054689219726605 0.497583413020245 no 1692 0.49781822667271 554 6842497 SGTC_2119 5528445 120.635 µM -0.00573224165686427 0.497468999259135 no 1693 0.497713178965226 551 791935 SGTC_2276 7947513 42.08 µM -0.00581260642811539 0.497434080392498 no 1694 0.497681118594272 561 2105100 SGTC_133 0724-0033 378.92 µM -0.00608839248209471 0.497314250221348 no 1695 0.497571097825193 549 280309 SGTC_1454 4239-0054 42.6 µM -0.00623232267291488 0.497251712058886 no 1696 0.497513679076229 551 1340767 SGTC_2682 pyrogallin 40.03 µM -0.0063366858298884 0.497206365950736 no 1697 0.497472045022592 555 822798 An ATP competetive kinase inhibitor. SGTC_1616 st002734 56.1 µM -0.00807109934408117 0.496452763750841 no 1698 0.496780132180815 553 4026101 SGTC_2610 ononetin 44.17 µM -0.00927843018062771 0.495928186142635 no 1699 0.496298495015246 555 259632 SGTC_2484 5809818 12.04 µM -0.0098027974500818 0.495700354022099 no 1700 0.496089312263869 551 2870548 SGTC_986 1493-0483 84 µM -0.00996392741875991 0.495630345006113 no 1701 0.496025033846255 552 40079 SGTC_595 3909-8003 73.7 µM -0.0106031480456649 0.495352612747961 no 1702 0.495770035199575 556 699517 SGTC_1516 st013856 110 µM -0.0109182657916652 0.495215699396021 no 1703 0.495644328686077 554 5281404 A mutagen and neurotoxin. SGTC_2287 7945887 168.79 µM -0.0109667740007555 0.495194623446023 no 1704 0.495624977869082 557 1245853 SGTC_2170 morpholine 200 µM -0.0112574922930617 0.495068311826342 no 1705 0.495509005211348 560 121171 Reacts with secondary amines. SGTC_818 4072-2707 53.5 µM -0.0114529282754337 0.494983398851953 no 1706 0.495431042561437 552 882871 SGTC_2887 9044784 58.44 µM -0.0120921856455907 0.494705656085301 no 1707 0.495176033444629 552 6465546 SGTC_335 4077-0256 27.6 µM -0.0127308640421787 0.494428167432352 no 1708 0.494921257257356 557 3121989 SGTC_3242 9133940 49.47 µM -0.0130196704725365 0.494302689652712 no 1709 0.494806049711353 554 17248444 SGTC_2448 5185112 27.17 µM -0.0136945541675064 0.494009475036526 no 1710 0.494536834092965 552 5718189 SGTC_2736 butenafine 14.65 µM -0.0145457874541467 0.493639646997948 no 1711 0.49419727500689 552 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1916 st067606 49.2 µM -0.0149918836850866 0.493445837550549 no 1712 0.494019327768567 556 19590279 SGTC_643 k048-0106 28.4 µM -0.0156525919441357 0.493158791349272 no 1713 0.493755774252988 559 6763920 SGTC_76 0433-0009 400.328 µM -0.0158542485772564 0.493071181866495 no 1714 0.493675334877999 556 2841569 SGTC_1902 st060212 70.5 µM -0.0158825572727365 0.493058883214298 no 1715 0.493664042764271 549 688944 SGTC_251 melphalan 456.522 µM -0.0161127557845785 0.492958874209244 no 1716 0.493572218596017 561 460612 A DNA alkylator. SGTC_721 1187-1332 279 µM -0.0161206248648521 0.492955455520348 no 1717 0.493569079694875 554 25730 SGTC_1731 st035964 63 µM -0.0162764418010131 0.492887761613333 no 1718 0.493506925885982 589 6739575 SGTC_1704 st028805 70.8 µM -0.0167938904537523 0.492662960053327 no 1719 0.493300521961325 557 2876101 SGTC_2007 4011539 71.82 µM -0.0169131768293649 0.492611137339116 no 1720 0.493252940340705 555 45595301 SGTC_553 k007-0256 45.7 µM -0.0176707874774738 0.492282004290327 no 1721 0.492950742612167 559 6287000 SGTC_623 k072-0108 16.9 µM -0.0178355382264591 0.49221043138499 no 1722 0.492885026929522 562 5382803 SGTC_1667 st014849 34.6 µM -0.0178546775259654 0.492202116687735 no 1723 0.492877392669386 554 5348460 SGTC_696 1560-0013 611 µM -0.0180803162847488 0.492104092564114 no 1724 0.492787390357539 559 1650269 SGTC_738 1315-0003 72.4 µM -0.0192007737653439 0.49161734000702 no 1725 0.492340470170917 559 6251474 SGTC_719 2810-4230 27.3 µM -0.0197883349067259 0.491362094846567 no 1726 0.492106111729417 555 721079 SGTC_2476 5806916 10.51 µM -0.0200925232730325 0.491229952350554 no 1727 0.491984782253313 560 2870194 SGTC_1289 0976-0073 69.1 µM -0.0206516172443776 0.490987078808221 no 1728 0.491761782311988 563 3391136 SGTC_2555 cholic acid 100 µM -0.0206528578055657 0.490986539905197 no 1729 0.491761287505211 561 6708657 Influences liver metabolism. SGTC_2849 9019321 12.99 µM -0.0217385988296869 0.490514897584062 no 1730 0.491328236813253 557 16489627 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0225328741940518 0.490169875346607 no 1731 0.491011444418645 562 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1545 lovastatin 49.4 µM -0.0229349537499493 0.489995220334206 no 1732 0.490851079330959 561 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_901 1112-0062 60.1 µM -0.0235693496568674 0.489719655835782 no 1733 0.490598060393596 559 1908457 SGTC_3065 9113888 49.47 µM -0.0246178369070378 0.4892642320284 no 1734 0.490179895908307 571 16648368 SGTC_41 0478-0632 82.643 µM -0.0248524112247342 0.489162343577278 no 1735 0.490086342918766 554 3750424 SGTC_740 k014-0057 261 µM -0.0260366347155525 0.488647981504656 no 1736 0.489614059035071 558 4012779 SGTC_2995 9067767 71.4286 µM -0.0264986670001499 0.488447304961931 no 1737 0.489429798403389 569 11673567 SGTC_791 1348-1292 225 µM -0.0270150198919051 0.488223038570783 no 1738 0.489223877131213 562 5437054 SGTC_1006 4099-6547 255 µM -0.0271518059611918 0.488163629205674 no 1739 0.489169327394939 562 3146833 SGTC_3029 9088683 49.47 µM -0.0272333856345325 0.488128197384778 no 1740 0.489136793844515 558 25236615 SGTC_1245 0418-0076 17.2 µM -0.0285025598385641 0.487576979753308 no 1741 0.48863066320203 566 6790114 SGTC_2721 ifenprodil 61.44 µM -0.028857799653841 0.487422699031649 no 1742 0.488489001294954 565 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3263 9137018 49.47 µM -0.02953098280308 0.487130340639417 no 1743 0.48822055450399 558 43844957 SGTC_727 3032-0951 202 µM -0.029810635907104 0.487008891418339 no 1744 0.488109038155213 567 3652836 SGTC_1441 4106-0040 13 µM -0.0303180568032692 0.486788529086494 no 1745 0.487906697972706 555 2904180 SGTC_2385 9074692 200 µM -0.0307134415882692 0.486616824498125 no 1746 0.487749035691483 557 17046906 SGTC_269 exalamide 29 µM -0.0308533753152088 0.486556055774789 no 1747 0.487693236655754 571 3316 A derivative of salicylamide. SGTC_705 1124-0212 310 µM -0.0311509610319213 0.486426824895225 no 1748 0.487574574170756 556 9554485 SGTC_1946 st076057 65.1 µM -0.0317336791847396 0.486173775293146 no 1749 0.487342218149563 560 953009 SGTC_2738 aclarubicin 5.55 µM -0.0323586595808887 0.485902379194258 no 1750 0.487093015042463 560 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2722 naftopidil 47.16 µM -0.0350807072730633 0.484720414908021 no 1751 0.48600769265412 561 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1845 st056753 3.01 µM -0.0354950584477913 0.484540507352616 no 1752 0.485842493340752 572 5375839 SGTC_2666 tannic acid 100 µM -0.0355694149455615 0.484508222761671 no 1753 0.485812848110026 560 16134267 A thiamine antagonist. SGTC_1673 st016611 27.3 µM -0.0370567351437275 0.483862469955376 no 1754 0.485219884334715 566 5226799 SGTC_917 harmaline 728.087 nM -0.0372677629898214 0.483770850959817 no 1755 0.4851357545178 569 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2987 9018338 71.43 µM -0.0377420119362572 0.483564956090701 no 1756 0.48494668958111 566 5055682 SGTC_792 4534-1957 155 µM -0.0380058886982456 0.483450396061641 no 1757 0.484841493459863 567 1717904 SGTC_2939 9044578 71.43 µM -0.0382977239660869 0.483323699657719 no 1758 0.484725152734312 565 2653634 SGTC_3324 9138759 60.749 µM -0.039161285700412 0.482948805717193 no 1759 0.484380899739648 572 45595710 SGTC_2419 paclitaxel 166.5 µM -0.039437505840014 0.48282889475061 no 1760 0.484270788910374 564 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3237 9133362 49.47 µM -0.0399077806918365 0.482624745540116 no 1761 0.484083323975639 572 43845137 SGTC_562 3772-2733 112 µM -0.0409950543546439 0.482152770875887 no 1762 0.483649919301362 570 2876874 YIL048W NEO1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0410720154215973 0.482119363783623 no 1763 0.483619242115063 572 5357218 A potent inhibitor of glutathione S-transferases. SGTC_337 1315-0038 354 µM -0.041412648101859 0.481971504202748 no 1764 0.483483464860391 568 1626437 SGTC_1646 st011709 75.6 µM -0.0424759253326851 0.48150997989904 no 1765 0.483059651613432 566 5757843 SGTC_1485 3909-9022 254 µM -0.0429838925873524 0.481289501206815 no 1766 0.482857186919643 561 714516 SGTC_1278 0874-0585 172 µM -0.0444322704094963 0.480660877280195 no 1767 0.482279919487047 567 766306 SGTC_671 0560-0003 407 µM -0.0446632878579488 0.480560615655626 no 1768 0.482187848262779 579 3238678 SGTC_2308 7584454 197.62 µM -0.0459845537466083 0.479987209783871 no 1769 0.481661280605119 578 893577 SGTC_1011 4112-3381 17.4 µM -0.0465940294517568 0.479722722063912 no 1770 0.481418395335607 604 2877139 SGTC_2719 novobiocin 32.65 µM -0.0472723819936249 0.479428355095354 no 1771 0.48114806972143 576 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_385 1494-0393 12.4 µM -0.0489499536006648 0.478700431597448 no 1772 0.480479589665345 590 3090647 SGTC_3266 9136860 49.47 µM -0.0519877334489638 0.477382475789682 no 1773 0.479269233743383 587 4871271 YPR165W RHO1 SGTC_2297 7971671 152.32 µM -0.0521479016760955 0.47731299275044 no 1774 0.479205422422407 572 909016 SGTC_2689 tacrolimus 100 µM -0.0524433925586333 0.477184806812315 no 1775 0.479087699702518 568 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3045 9092950 49.47 µM -0.05250082048949 0.477159894462078 no 1776 0.479064820791021 587 44120432 SGTC_1223 0764-0573 147 µM -0.0528055698346031 0.477027695088075 no 1777 0.478943411804144 571 1609797 SGTC_1828 st055811 49 µM -0.0528259343081932 0.477018861128984 no 1778 0.478935298878024 590 5877589 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0533888577195645 0.476774673573101 no 1779 0.478711041402037 593 15053 SGTC_3111 9122088 49.47 µM -0.0535009141454555 0.476726066249309 no 1780 0.478666401155743 575 16876704 SGTC_555 4296-0685 37 µM -0.0535792267372733 0.476692096377019 no 1781 0.478635203698213 578 2908540 YHR072W ERG7 SGTC_1406 3909-7906 11.9 µM -0.0539947531219621 0.476511855172911 no 1782 0.478469672273732 571 X1406 SGTC_1907 st060210 83.7 µM -0.0551733802314474 0.476000633113692 no 1783 0.478000168060495 584 688793 SGTC_2379 9035213 200 µM -0.0556318050219908 0.475801804882031 no 1784 0.477817563493466 577 646551 SGTC_660 4031-1742 102 µM -0.056091897970942 0.475602259194062 no 1785 0.477634299130498 567 6738706 SGTC_1715 st032160 10.2275 µM -0.0561494166446265 0.475577313352514 no 1786 0.477611388606748 572 5289825 SGTC_2402 5553605 200 µM -0.056198913297291 0.475555846737105 no 1787 0.477591673429799 586 6758546 SGTC_1390 3413-2614 145 µM -0.0567571661481131 0.475313738337858 no 1788 0.477369317682016 596 3421432 SGTC_1852 st056254 31.4 µM -0.0568077159360089 0.475291815874373 no 1789 0.477349183718959 583 442583 SGTC_1234 0326-0494 15.5 µM -0.0570752640912495 0.47517578667109 no 1790 0.477242620345204 577 1547813 SGTC_1903 st060211 78.3 µM -0.0582743233599334 0.474655809490397 no 1791 0.476765059869905 558 688960 SGTC_1733 st037357 54.9 µM -0.0602885148747834 0.473782444336625 no 1792 0.475962924554919 570 1272339 YGL099W LSG1 SGTC_1048 3161-0300 24.5 µM -0.0614386100040406 0.473283812642961 no 1793 0.475504952043169 575 2165101 SGTC_576 1073-0113 22.7 µM -0.0617606235060902 0.47314420893021 no 1794 0.475376730742494 584 5439563 SGTC_1362 1611-0397 101 µM -0.0620689898123011 0.473010524828634 no 1795 0.475253945955528 570 27816 SGTC_2753 fluvastatin 17.09 µM -0.0635211740972063 0.472381009641506 no 1796 0.474675749399368 581 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1190 1486-1332 13 µM -0.0636385043305485 0.472330150517673 no 1797 0.474629035921215 575 4150046 SGTC_2204 7233102 200 µM -0.0636576930732938 0.472321832818288 no 1798 0.474621396210651 592 2172480 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0643893743181323 0.472004681700768 no 1799 0.474330095268168 564 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2497 7-hydroxyflavone 100 µM -0.0644365466092491 0.47198423522784 no 1800 0.47431131524665 606 5281894 SGTC_2974 9094440 9.66 µM -0.0644676227824859 0.471970765535846 no 1801 0.474298943370765 583 25236134 SGTC_1379 2144-0755 36.5 µM -0.065340493680617 0.471592440530417 no 1802 0.473951450958802 581 5392327 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.0654726204571883 0.471535175565779 no 1803 0.473898852629998 569 4000243 SGTC_3202 9113761 49.47 µM -0.0655027044889545 0.471522136950912 no 1804 0.473886876545836 578 4798415 SGTC_2486 5283202 22.39 µM -0.0661842503325576 0.471226758758757 no 1805 0.473615567846827 580 1377751 SGTC_3353 9151644 39.2805 µM -0.067027695332405 0.470861236300771 no 1806 0.4732798275434 590 4909158 SGTC_3076 9116187 49.47 µM -0.0673617661715194 0.470716467306389 no 1807 0.473146853099332 605 27241210 SGTC_1866 st057638 64 µM -0.0677850769371656 0.47053303191225 no 1808 0.47297836165794 581 688802 SGTC_945 3381-0768 11.3 µM -0.0701389525434073 0.469513130219244 no 1809 0.47204153169123 578 1126236 YIL048W NEO1 SGTC_2085 5307070 144.047 µM -0.0705162649614695 0.469349664400122 no 1810 0.471891377604154 600 2840351 SGTC_377 3970-0964 33.1 µM -0.0705791444644475 0.469322423154519 no 1811 0.471866354658725 570 16481235 SGTC_1995 st072814 61.1 µM -0.0712889899809732 0.469014907240918 no 1812 0.471583878828849 581 5769371 SGTC_3225 9130819 49.47 µM -0.0716786998941177 0.468846086805373 no 1813 0.471428803787056 588 4547121 SGTC_440 fluspirilene 35.1 µM -0.0722294725115359 0.468607504350489 no 1814 0.471209645375147 609 3396 An atypical antipsychotic. SGTC_2873 9040596 71.43 µM -0.0743455946240834 0.467690952906804 no 1815 0.470367699062605 569 6463863 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0754220579275402 0.467224772070923 no 1816 0.469939454751727 579 115019 SGTC_2258 7960471 200 µM -0.0754543894498407 0.467210771044639 no 1817 0.469926592990274 578 2974708 SGTC_2891 9063876 19.48 µM -0.0757363415059722 0.467088674644202 no 1818 0.469814431335527 575 6472478 SGTC_1527 coumarin 137 µM -0.076647403905292 0.466694169791438 no 1819 0.469452023490266 611 323 A hepatotoxic, DNA x-linker. SGTC_3239 9133757 49.47 µM -0.0772509985125714 0.466432821493655 no 1820 0.46921193593882 577 17036923 SGTC_1812 st052057 4.327 µM -0.0772974168589195 0.466412723575653 no 1821 0.469193472904438 589 3645418 SGTC_1506 4226-2149 212 µM -0.078259181716126 0.465996324140642 no 1822 0.468810943055685 607 991114 SGTC_3128 9127691 49.47 µM -0.0799072426819 0.46528287721193 no 1823 0.468155514712678 590 41316314 SGTC_2346 9031566 143.75 µM -0.0810939551712966 0.464769217378822 no 1824 0.46768361646548 591 4771086 SGTC_2697 mebhydrolin 72.4 µM -0.0815844285564565 0.464556936653138 no 1825 0.467488592111753 595 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3055 9094636 49.47 µM -0.0825567894065945 0.4641361211374 no 1826 0.467101980494625 590 25236176 SGTC_3146 9095609 49.47 µM -0.0825907634497544 0.464121418671884 no 1827 0.467088472941104 592 17173999 SGTC_1941 st076221 61.8 µM -0.0836062060981687 0.463682002642694 no 1828 0.466684766231391 588 2828568 SGTC_2332 7982454 138.89 µM -0.0836551681185298 0.463660816252592 no 1829 0.466665301399906 577 2981748 SGTC_1179 1021-1431 9.29 µM -0.0848062674195535 0.463162753089723 no 1830 0.466207705406771 600 2840958 SGTC_606 k015-0008 38.6 µM -0.0848728264487537 0.463133955768276 no 1831 0.466181247585805 607 1970475 SGTC_394 menadione 8.33 µM -0.0876036973513316 0.461952589898263 no 1832 0.465095831709464 584 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_13 0199-0087 65 µM -0.0885438088570904 0.461545977841395 no 1833 0.464722233307615 583 4589825 SGTC_1806 st050005 60.3 µM -0.0903871815044521 0.460748809112474 no 1834 0.463989771337044 582 5194765 SGTC_2677 mitomycin C 100 µM -0.0917329556932229 0.460166926855168 no 1835 0.4634551064585 591 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1073 triclabendazole 3.09 µM -0.0934727653699829 0.45941479917531 no 1836 0.462763992518305 597 50248 An antihelmetic and likely tubulin inhibitor. SGTC_100 0086-0128 49.5915 µM -0.0940374541405245 0.459170712726032 no 1837 0.462539702222979 631 93297 SGTC_425 3825-7017 13.1 µM -0.0947386026040358 0.458867663069127 no 1838 0.462261227707358 576 3397440 SGTC_810 3825-7150 143 µM -0.0950326282556273 0.458740586712317 no 1839 0.462144455296153 584 22330411 YGL099W LSG1 SGTC_920 mycophenolic acid 780.421 nM -0.0966249659903291 0.458052460204151 no 1840 0.461512114633724 589 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_4 0960-0234 25.671 µM -0.096958592456481 0.457908299856726 no 1841 0.461379638945927 579 6821112 SGTC_652 0437-0092 114 µM -0.0970236553727474 0.457880186746702 no 1842 0.461353804400357 592 3091274 SGTC_534 k292-0788 63.4 µM -0.0979629498793798 0.457474349457752 no 1843 0.460980856763147 621 4146317 SGTC_1425 4048-4433 7.33 µM -0.0984518956523474 0.457263110098709 no 1844 0.460786734011855 594 23734946 SGTC_1022 4477-0945 21.3 µM -0.0990204187144234 0.457017506129709 no 1845 0.460561028993547 587 4648966 SGTC_1409 3909-8004 61.9 µM -0.102464800485147 0.455529875423713 no 1846 0.459193875451086 582 2119279 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.102536253835387 0.455499021203104 no 1847 0.459165519041845 594 442882 SGTC_175 3793-3120 23.7 µM -0.103015162814832 0.455292230792773 no 1848 0.458975468396413 615 5322297 SGTC_725 1497-0963 19 µM -0.104001916237707 0.454866194041446 no 1849 0.458583913940565 576 3549977 SGTC_1555 citronellol 128 µM -0.104561113200389 0.454624780387497 no 1850 0.45836203633665 593 8842 A terpine precursor. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.10482818195633 0.454509488737473 no 1851 0.458256073639618 606 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_481 bay k-8644 50 µM -0.104864523851508 0.454493800500227 no 1852 0.458241654790736 642 2303 A calcium channel antagonist. SGTC_54 0159-0055 9 µM -0.105649641187339 0.454154894793586 no 1853 0.457930168572603 631 3319099 SGTC_1119 parthenolide 318.541 nM -0.107782630533818 0.453234332507721 no 1854 0.457084060720362 646 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_728 3030-5151 22.5 µM -0.110676828741999 0.451985647958805 no 1855 0.455936310529729 601 3125388 SGTC_1668 st014914 51.6 µM -0.111440136380646 0.451656402055415 no 1856 0.455633667014433 586 2839556 SGTC_346 4513-0042 7.16 µM -0.11145315947436 0.451650784948598 no 1857 0.455628503716497 605 2827372 SGTC_2917 7979103 53.79 µM -0.111701198543126 0.451543802852561 no 1858 0.455530164489649 621 2980565 SGTC_3349 9149703 23.001 µM -0.111955414493149 0.451434160248458 no 1859 0.455429379162422 602 4910494 SGTC_50 0929-0078 56.389 µM -0.112917729791727 0.451019150068686 no 1860 0.455047889944695 606 1377751 SGTC_991 3996-0057 64.7 µM -0.113223650008569 0.450887229446974 no 1861 0.454926623116288 593 715343 SGTC_1407 3909-7909 12.3 µM -0.113832815902011 0.450624557704209 no 1862 0.454685162167969 589 4411780 SGTC_1830 st055982 50.3 µM -0.115164646777125 0.450050348998799 no 1863 0.454157309985787 628 455313 An antimicrobial agent. SGTC_132 0417-1715 25.805 µM -0.115407502837138 0.449945654699889 no 1864 0.454061066148103 600 6769098 SGTC_2716 st080858 38.6235 µM -0.116170263252529 0.449616854350543 no 1865 0.453758801821349 584 5296050 SGTC_1735 st034310 56.75 µM -0.116344951826583 0.449541556843981 no 1866 0.453689580539145 581 871153 SGTC_1463 k081-0032 34.1 µM -0.116548297703889 0.449453909224049 no 1867 0.453609005419293 604 977755 SGTC_3275 9138069 49.47 µM -0.116970790545455 0.449271811174301 no 1868 0.45344160016127 587 17617007 SGTC_3004 9076122 71.4286 µM -0.117332764194715 0.449115805913411 no 1869 0.453298181133573 622 44782551 SGTC_779 1360-0071 233 µM -0.117551986033269 0.449021328383443 no 1870 0.453211325332238 590 7566 SGTC_2329 6138490 200 µM -0.117815798591618 0.448907637526454 no 1871 0.453106805633386 650 720019 SGTC_2642 cholecalciferol 100 µM -0.118602590522277 0.448568592002772 no 1872 0.452795106450565 609 9821465 A vitamin D precursor, similar to steriods. SGTC_697 0508-1955 564 µM -0.119383869142937 0.44823195944721 no 1873 0.452485620226088 595 6243113 SGTC_1194 1488-0194 225 µM -0.119912359429051 0.448004267903855 no 1874 0.45227628685781 607 1391452 SGTC_670 4204-0025 119 µM -0.119943402507262 0.447990894024605 no 1875 0.45226399120244 601 719039 SGTC_3100 9120536 49.47 µM -0.120361996792144 0.447810562358536 no 1876 0.452098197330582 645 16421196 SGTC_1228 0124-0032 52.5 µM -0.120966184589279 0.447550295483177 no 1877 0.451858909626094 615 X1228 SGTC_1380 2291-0730 164 µM -0.123035206620924 0.44665919153751 no 1878 0.451039609449773 608 2999191 SGTC_955 1216-0110 33 µM -0.123230939255559 0.446574905618992 no 1879 0.450962113148681 597 3619719 SGTC_2306 7482397 179.52 µM -0.123277027959507 0.446555059362557 no 1880 0.450943865548384 627 891448 SGTC_2495 cafestol 54.53 µM -0.12384530307647 0.446310365435271 no 1881 0.450718880615492 644 16667697 An anti-infammatory. SGTC_684 1140-0066 328 µM -0.126060506740597 0.445356715562621 no 1882 0.449842014536436 625 6813534 SGTC_1303 1160-0052 261 µM -0.126426691369778 0.445199102602355 no 1883 0.449697087503349 603 3562476 SGTC_1432 4049-0298 68.4 µM -0.126465877959403 0.445182236447474 no 1884 0.449681578794581 599 741646 SGTC_452 diindolylmethane 8 µM -0.127913505449595 0.444559238255579 no 1885 0.449108711522088 627 3071 Inhibits expression of several cancer promoting factors. SGTC_624 k048-0052 28 µM -0.127933451723124 0.444550655168432 no 1886 0.449100818953798 599 6835531 SGTC_502 l-744,832 89.3 µM -0.133002253623012 0.442370351163122 no 1887 0.447095799101281 634 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_473 2-arachidonoylglycerol 10 µM -0.133629015782388 0.442100874356486 no 1888 0.446847969341235 594 5282280 An endocannabinoid. SGTC_3080 9117754 49.47 µM -0.133833661539996 0.442012892573056 no 1889 0.446767054286101 588 9550191 SGTC_2592 piperlongumine 83.33 µM -0.134440462779022 0.441752031995194 no 1890 0.446527143683358 618 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.134712389267213 0.441635140455382 no 1891 0.446419638633454 604 140250 A respiratory chain inhibitor. SGTC_348 k064-0012 10.7 µM -0.134852510852096 0.441574909146261 no 1892 0.446364243662051 611 5066323 SGTC_898 1000-0849 28.3 µM -0.134860780651795 0.441571354412362 no 1893 0.446360974353214 601 6751807 SGTC_2469 5655019 90.81 µM -0.135933659166538 0.441110222720724 no 1894 0.445936863133207 617 2788239 SGTC_3189 9110682 49.47 µM -0.13616317692553 0.441011584512449 no 1895 0.445846142276228 622 17122418 SGTC_2000 st075254 36.4 µM -0.137167462566188 0.440580022960501 no 1896 0.445449214443278 605 17234175 SGTC_2356 9061756 188.97 µM -0.13751059486683 0.440432588321917 no 1897 0.445313609402793 610 20104043 SGTC_1422 4031-0024 15.5 µM -0.138112509813835 0.440173981762578 no 1898 0.445075749563113 623 782427 SGTC_2643 anethole 100 µM -0.138533685928675 0.439993042950488 no 1899 0.444909324374454 627 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2295 7971645 200 µM -0.139921964590947 0.439396722251161 no 1900 0.444360823386654 624 2978226 YKL099C UTP11 SGTC_1039 k821-0043 94 µM -0.140475044139906 0.439159190891424 no 1901 0.444142334427078 594 15992768 SGTC_2028 5153890 36.43 µM -0.141672256057296 0.438645098812745 no 1902 0.443669445161053 630 2830968 YPR165W RHO1 SGTC_3238 9133470 49.47 µM -0.141741341118721 0.43861543630204 no 1903 0.443642159547756 617 3534688 SGTC_1548 st061468 90.8 µM -0.142213450329033 0.438412739712625 no 1904 0.443455703973335 602 390799 SGTC_2695 st077686 51.995 µM -0.142554368513519 0.438266379058894 no 1905 0.443321068975974 616 2876092 SGTC_3250 9135583 49.47 µM -0.144080572889086 0.437611263263417 no 1906 0.442718422617285 605 7699353 SGTC_427 1354-0053 47.3 µM -0.144946623260771 0.43723959128562 no 1907 0.44237650753153 654 6813657 SGTC_2463 5473429 200 µM -0.144976438744403 0.437226796732624 no 1908 0.442364737196477 623 5399405 SGTC_1652 st011932 78 µM -0.14625658176543 0.436677518156878 no 1909 0.441859419970767 615 1551076 SGTC_2985 9022375 71.43 µM -0.147478746571356 0.436153230518548 no 1910 0.441377077034603 657 4939335 SGTC_943 3253-1379 105 µM -0.148831340241053 0.435573121937353 no 1911 0.440843360054408 618 668464 SGTC_1415 3966-0071 78.1 µM -0.148957594832426 0.435518980155782 no 1912 0.440793546998339 632 2893185 SGTC_3108 9121785 49.47 µM -0.149538299704461 0.435269971949166 no 1913 0.440564445153849 591 17140271 SGTC_2983 9022671 12.99 µM -0.150389800776935 0.434904891855475 no 1914 0.440228543779318 659 6405161 SGTC_3218 9131285 49.47 µM -0.150532386528347 0.43484376379615 no 1915 0.440172300543674 642 17156417 SGTC_1503 4585-0012 61.3 µM -0.150586976146002 0.434820361046706 no 1916 0.440150767878993 631 2922052 SGTC_1669 st015249 58.4 µM -0.15116769215553 0.434571420326367 no 1917 0.439921717652437 619 722793 SGTC_575 k072-0246 11.9 µM -0.151880486776493 0.434265895756548 no 1918 0.439640599514399 606 6796779 SGTC_3264 9137442 49.47 µM -0.152880764277647 0.433837213880111 no 1919 0.439246152728895 631 17015726 SGTC_3214 9129694 49.47 µM -0.155786311715738 0.432592446933645 no 1920 0.438100730277278 619 17158655 SGTC_1352 1496-0991 99 µM -0.156132112653663 0.432444346476508 no 1921 0.437964443256389 621 3000039 SGTC_2649 anisomycin 9.56 µM -0.156645087667024 0.432224665792758 no 1922 0.437762283168859 645 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_724 3910-0327 137 µM -0.157230772055907 0.431973873062705 no 1923 0.437531488657155 626 2885483 SGTC_1133 3473-0247 50 µM -0.157772156844052 0.431742074001802 no 1924 0.437318169725239 599 711311 SGTC_873 0591-4978 488 µM -0.15791393914603 0.43168137243674 no 1925 0.437262307016627 614 3305145 SGTC_1853 st056710 91.2 µM -0.158014734896525 0.431638219514018 no 1926 0.437222593909106 646 269167 SGTC_621 3584-0052 32.1 µM -0.158210066492137 0.431554595997319 no 1927 0.437145635871719 647 2273927 SGTC_2723 salbutamol 83.58 µM -0.158334493304689 0.431501329165311 no 1928 0.437096614610769 615 9884233 β2-adrenoceptor agonist SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.158750278912579 0.431323341344757 no 1929 0.436932811792399 619 364106 SGTC_2159 5658611 73.75 µM -0.158839003365278 0.431285362344133 no 1930 0.436897859322787 647 793844 SGTC_3098 9119039 49.47 µM -0.159023897621618 0.431206219360391 no 1931 0.436825022915031 603 17161528 SGTC_2934 9036370 36.88 µM -0.159068977290074 0.431186923671463 no 1932 0.436807264758794 620 6462800 SGTC_2450 5739737 12.93 µM -0.159116103363978 0.431166752224375 no 1933 0.436788700601723 602 2262825 SGTC_3339 9145883 14.936 µM -0.1601719912921 0.430714846035829 no 1934 0.436372796112551 626 2030670 SGTC_153 4077-0274 519.67 µM -0.160175960387983 0.430713147485598 no 1935 0.436371232854798 602 3121976 SGTC_947 3447-0010 211 µM -0.160635536268948 0.430516483481442 no 1936 0.436190232222892 635 748350 SGTC_1756 st041558 35.5 µM -0.161452017660037 0.430167133223438 no 1937 0.435868699920778 655 3955792 SGTC_3284 9108171 64.8615 µM -0.161778104695125 0.430027624677897 no 1938 0.435740297907225 609 8687505 SGTC_784 4579-0127 173 µM -0.161816884172526 0.430011034386046 no 1939 0.435725028314827 653 1948547 SGTC_210 3551-0445 56.827 µM -0.162582621161352 0.429683468930279 no 1940 0.435423535610704 652 2865180 YOR207C RET1 SGTC_470 aa-861 153 µM -0.163554980048547 0.429267584949079 no 1941 0.435040744026918 615 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2253 7938677 135.83 µM -0.164120062163343 0.429025931827841 no 1942 0.434818314316449 628 2301972 SGTC_1617 st002906 78 µM -0.165035360537796 0.428634567828992 no 1943 0.434458074982993 646 5150859 SGTC_1779 st039427 55 µM -0.168036435641175 0.427351859952899 no 1944 0.433277307552955 626 1124498 SGTC_34 0469-0683 81.75 µM -0.168856367948747 0.427001540607923 no 1945 0.432954809812604 619 3690923 SGTC_1266 0828-0227 32.9 µM -0.169468618804317 0.426739991515533 no 1946 0.432714026943263 630 3913820 SGTC_3330 9141424 71.43 µM -0.172578107663671 0.42541214013105 no 1947 0.431491530614752 625 27261020 SGTC_1675 st018485 24.5 µM -0.175327018629833 0.42423897069287 no 1948 0.430411341388485 617 3323024 SGTC_1792 st045773 43.6 µM -0.175632072408841 0.424108822209924 no 1949 0.430291501928542 634 2919270 SGTC_2710 st078562 53.7235 µM -0.176546530576781 0.423718726406473 no 1950 0.429932298300876 652 17250908 SGTC_2400 5203494 178.7 µM -0.177354206276447 0.42337424474505 no 1951 0.429615087563342 603 6777674 SGTC_1635 st007035 42.4 µM -0.178241338799143 0.42299594146162 no 1952 0.429266722909247 619 3716403 SGTC_2687 chenodiol 100 µM -0.178542616595043 0.422867482561018 no 1953 0.429148427807666 618 5702181 A cholesterol synthesis inhibitor. SGTC_1742 st038235 28.8875 µM -0.178755022891708 0.422776921640431 no 1954 0.429065031444706 622 564103 YBR002C RER2 SGTC_1641 st009299 47.1 µM -0.1794764230085 0.422469378115011 no 1955 0.428781814227534 625 4046054 SGTC_466 geldanamycin 89.2 µM -0.179648275161284 0.422396121966756 no 1956 0.428714351539355 623 5288382 HSP90 inhibitor. SGTC_2102 5377816 72.7585 µM -0.179871532943841 0.422300956931129 no 1957 0.428626712046094 633 1379702 SGTC_3348 9149464 3.537 µM -0.182544759848691 0.421161830964721 no 1958 0.4275776155604 627 1951442 SGTC_1666 st014829 29 µM -0.182582934041307 0.421145568782116 no 1959 0.427562637950854 639 3858230 SGTC_3196 9111891 49.47 µM -0.183549948764639 0.420733666043802 no 1960 0.42718326548224 627 18891510 SGTC_2957 9076800 11.52 µM -0.184944991141548 0.420139596664066 no 1961 0.426636090910818 657 16459615 SGTC_580 1123-0028 41 µM -0.185519049043517 0.419895190729473 no 1962 0.426410970308559 634 1677248 YPR107C YTH1 SGTC_199 4063-0024 41.6 µM -0.18584865138727 0.419754876036289 no 1963 0.42628172539938 628 306215 SGTC_1515 3460-0031 42.1 µM -0.187231818206314 0.419166160861573 no 1964 0.425739439308142 618 2876596 SGTC_2122 5258151 111.688 µM -0.187376552347688 0.419104568324947 no 1965 0.425682702760133 642 2173356 SGTC_2062 5245942 200 µM -0.187450892412618 0.419072933206902 no 1966 0.425653561660007 620 1376160 SGTC_2059 5238311 157 µM -0.187732376056637 0.418953153708078 no 1967 0.425543224530124 621 703021 SGTC_578 3460-0051 92 µM -0.188322567337477 0.418702034508244 no 1968 0.425311897834789 653 2876744 SGTC_1827 berberine 7.24 µM -0.18833808943856 0.418695430489943 no 1969 0.425305814261745 645 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1216 1165-0504 9.65 µM -0.188402703938377 0.418667939912806 no 1970 0.425280490108743 643 6304004 SGTC_540 1187-0821 17.3 µM -0.190166445559873 0.417917700642285 no 1971 0.424589351932451 639 847520 SGTC_2131 toluylene red 5.2905 µM -0.190386497191358 0.417824118613455 no 1972 0.42450313892158 624 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2005 4024620 188 µM -0.190513682619278 0.417770032199973 no 1973 0.424453311177859 637 236743 SGTC_3027 9089541 49.47 µM -0.191056323381739 0.41753928824572 no 1974 0.424240733063453 641 9943819 SGTC_3043 9092303 49.47 µM -0.19116497431516 0.417493090654354 no 1975 0.424198171987566 637 25236084 SGTC_129 0088-0017 176.636 µM -0.191492815424808 0.417353701889606 no 1976 0.424069754425427 665 182446 SGTC_2187 6125751 200 µM -0.191640575711425 0.417290881790282 no 1977 0.424011878364585 640 874498 SGTC_36 0335-0881 14.2 µM -0.192281319660131 0.417018494756714 no 1978 0.423760925063913 633 23828853 SGTC_1021 4476-0760 85.3 µM -0.192805858025372 0.416795537587817 no 1979 0.423555507765848 629 746768 SGTC_328 k915-0120 63.5 µM -0.196481417357905 0.415233980760115 no 1980 0.422116687996684 632 6624543 SGTC_2826 7992541 19.48 µM -0.197444363022046 0.414825094679356 no 1981 0.421739908085777 656 2985066 SGTC_3046 9092212 49.47 µM -0.197698876745596 0.414717038434192 no 1982 0.421640334298517 613 25236637 SGTC_1089 terbinafine 2.25 µM -0.197740585447585 0.414699331219434 no 1983 0.421624017017872 639 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1575 cyproterone acetate 48 µM -0.197997729946144 0.414590165675758 no 1984 0.421523419906782 669 9880 An androgen receptor antagonist and liver toxin. SGTC_2872 9044037 25.97 µM -0.198551744738985 0.414354992223816 no 1985 0.421306702028619 617 6465195 SGTC_2859 9028643 45.46 µM -0.201351246199224 0.413167104505406 no 1986 0.420211967160428 633 17151580 SGTC_318 1488-0629 67.2 µM -0.201981206572945 0.412899908108373 no 1987 0.419965708182974 653 3662576 SGTC_2404 5161160 200 µM -0.20371760092279 0.412163629249961 no 1988 0.419287093536485 658 2831543 SGTC_736 0958-0254 92.6 µM -0.203730039930107 0.412158355881348 no 1989 0.419282233008573 665 6812352 SGTC_3302 9125395 16.351 µM -0.203988034536338 0.412048985726095 no 1990 0.419181424688844 646 17599668 SGTC_407 eburnamonine 100 µM -0.204225409310766 0.411948362850088 no 1991 0.419088678008776 640 3195 SGTC_2910 7948405 25.97 µM -0.205989916310258 0.411200572382191 no 1992 0.418399394010063 630 2971328 SGTC_1743 st037606 46.3785 µM -0.206534199671734 0.410969972398855 no 1993 0.418186826542369 636 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1520 flindersine 88 µM -0.20664939485598 0.410921170866465 no 1994 0.418141840632583 661 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3078 9116413 49.47 µM -0.207124337365202 0.410719979782051 no 1995 0.417956377867681 625 17177322 SGTC_2911 7942208 15.64 µM -0.20792398075731 0.410381294775266 no 1996 0.417644162206292 637 1243384 SGTC_1905 st060207 84.5 µM -0.209015454682495 0.409919114292023 no 1997 0.417218086990131 624 1948547 SGTC_702 1488-0190 94 µM -0.211610875841134 0.408820596712505 no 1998 0.416205311892516 631 949357 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.212661394094456 0.408376165632639 no 1999 0.41579554049016 646 1377 SGTC_665 3914-0008 307 µM -0.213620900242224 0.407970340968765 no 2000 0.415421349783406 669 1069549 SGTC_3306 9127676 59.7925 µM -0.213645700269154 0.407959853064407 no 2001 0.415411679219601 632 41905287 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.213952920502802 0.407829935433481 no 2002 0.415291885500713 676 6728940 SGTC_212 3807-4682 38.772 µM -0.214210766310449 0.407720905135759 no 2003 0.415191350321537 638 3125501 YBL034C STU1 SGTC_2136 5328288 199.296 µM -0.214458800310553 0.407616030512285 no 2004 0.415094646047672 638 262395 SGTC_630 4356-0227 183 µM -0.218786863857458 0.405787095246013 no 2005 0.413408040054759 670 779312 SGTC_646 4092-0839 27.3 µM -0.221258488030593 0.404743565522623 no 2006 0.412445585346103 653 877796 SGTC_2732 terfenadine 20 µM -0.222469490546832 0.404232522048283 no 2007 0.411974210600826 640 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2561 acetosyringone 100 µM -0.222740436526651 0.404118205087775 no 2008 0.411868764024034 642 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_693 4161-2696 114 µM -0.223245852225505 0.403904983042271 no 2009 0.411672083689751 639 805759 SGTC_3299 9121982 43.1275 µM -0.223966877560697 0.403600850199222 no 2010 0.411391538218791 662 17594604 YPL160W CDC60 SGTC_1010 4112-3296 15.2 µM -0.224492364047453 0.403379233529376 no 2011 0.411187103956215 645 704384 SGTC_2341 7987486 176.74 µM -0.224724680136703 0.403281267312223 no 2012 0.411096731831168 640 1258686 SGTC_2477 5967686 25.23 µM -0.224825579517569 0.403238720575282 no 2013 0.41105748293471 644 776118 SGTC_3258 9138477 49.47 µM -0.225053652946739 0.403142551954958 no 2014 0.410968767828273 617 4970355 SGTC_613 3914-0030 117 µM -0.225610408061967 0.402907817214493 no 2015 0.410752222544975 633 1145395 SGTC_1868 st057644 42.7 µM -0.226061583328167 0.402717621886626 no 2016 0.410576761616012 641 688665 SGTC_1387 3342-1166 1.8 µM -0.226338742359453 0.402600795437648 no 2017 0.410468984034996 644 3418228 SGTC_2196 6573537 42.6665 µM -0.227401168607283 0.402153048412802 no 2018 0.41005590583618 665 2903087 SGTC_2811 7967822 32.47 µM -0.229282559745054 0.401360473549446 no 2019 0.409324653880764 637 2232244 SGTC_82 0054-0107 293.755 µM -0.22931842857804 0.401345366993529 no 2020 0.409310715574935 637 3104697 SGTC_1120 ficusin 1.78878 µM -0.231125071794857 0.400584670436884 no 2021 0.40860881894882 661 6199 A DNA cross-linker. SGTC_90 0870-0863 4.608 µM -0.232088227796572 0.400179282411343 no 2022 0.408234744063938 671 1738164 SGTC_2706 st078239 82.5 µM -0.232096930479676 0.400175619980751 no 2023 0.408231364457159 632 15434492 SGTC_2261 9010538 184.68 µM -0.234529192038844 0.39915237408272 no 2024 0.407287086538909 719 6457250 SGTC_2665 lovastatin 100 µM -0.235080469435912 0.398920549184422 no 2025 0.40707313855364 654 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2844 9010103 25.97 µM -0.2351555228958 0.398888990223815 no 2026 0.407044012826183 710 2480525 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.235189823676228 0.398874567431535 no 2027 0.40703070201627 637 5355888 SGTC_3121 9125696 49.47 µM -0.235391703604037 0.398789683757238 no 2028 0.406952362379054 653 1235365 SGTC_2925 9010536 32.5 µM -0.236836667844217 0.39818226519663 no 2029 0.406391751926834 649 2994177 SGTC_539 4859-0462 2.54 µM -0.238346876774731 0.39754768339136 no 2030 0.405806033170244 642 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2388 9080168 200 µM -0.240077412108668 0.396820854902121 no 2031 0.405135122361442 666 15943073 SGTC_3191 9110352 49.47 µM -0.240425637880583 0.396674642566003 no 2032 0.405000152419187 642 17122424 SGTC_206 4546-0025 72.014 µM -0.24293329241001 0.395622163782304 no 2033 0.404028537178697 702 6620745 YIL048W NEO1 SGTC_3315 9136395 68.55 µM -0.24346009765394 0.39540115665691 no 2034 0.403824496360341 715 16876844 SGTC_2031 5180455 200 µM -0.245832624857535 0.394406243815832 no 2035 0.402905900448102 654 29949 SGTC_245 methotrexate 289.6 µM -0.245916830780219 0.394370944904165 no 2036 0.402873307383122 659 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_362 0310-0100 9.03 µM -0.246188188649615 0.394257198268818 no 2037 0.402768279166254 665 790235 SGTC_3279 9140807 49.47 µM -0.249751186709347 0.392764515896748 no 2038 0.401389885474912 646 45595718 SGTC_1561 5-methoxyflavone 52.9 µM -0.249780328002889 0.392752313910611 no 2039 0.401378616806245 640 94525 SGTC_1761 st044296 37 µM -0.250066559824047 0.392632469079109 no 2040 0.401267937969403 666 1826700 SGTC_1160 4092-0570 10.5 µM -0.250750384022166 0.39234619414917 no 2041 0.401003551981321 642 4994975 SGTC_3030 9087619 49.47 µM -0.252167812747484 0.391752990004566 no 2042 0.400455677998761 647 25236973 SGTC_1291 0993-0025 5.79 µM -0.253057590036745 0.391380740232738 no 2043 0.4001118553247 663 4353356 SGTC_2438 5259590 200 µM -0.253185187650683 0.391327366276111 no 2044 0.400062556121502 668 1201127 SGTC_2525 harmine 47.85 µM -0.25320271170046 0.391320036143083 no 2045 0.400055785573095 660 5280953 A monoamine oxidase inhibitor SGTC_31 0508-1974 57.237 µM -0.254575611989614 0.390745885978793 no 2046 0.399525448749668 639 6810525 SGTC_997 3996-0078 137 µM -0.256111619360085 0.390103806297049 no 2047 0.398932325092097 658 735687 SGTC_1730 st033808 45.1 µM -0.256657119541246 0.389875849090674 no 2048 0.398721738249882 648 1045166 SGTC_2396 5342950 42.78 µM -0.257076151385921 0.38970076702023 no 2049 0.398559993715158 642 1886677 SGTC_115 0527-0192 112.043 µM -0.260002369985724 0.388478744818202 no 2050 0.397430972734442 681 4233931 SGTC_992 3909-8734 162 µM -0.260489578251404 0.388275387886909 no 2051 0.397243076633408 692 4288319 SGTC_2949 9072542 2.23 µM -0.260713600157351 0.388181893165021 no 2052 0.397156688639032 691 16457352 SGTC_2752 diclazuril 33.15 µM -0.261181418665137 0.387986671725187 no 2053 0.396976303347137 669 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2091 4-phenylthiadiazole 200 µM -0.261854128286489 0.387705998509577 no 2054 0.396716953102562 652 270010 SGTC_1665 st014639 11.4 µM -0.261997464637272 0.387646202163483 no 2055 0.396661698431754 660 981133 YIL048W NEO1 SGTC_1507 4075-3230 155 µM -0.263149909321112 0.387165527977662 no 2056 0.396217518504558 666 659771 SGTC_91 0417-1751 58.384 µM -0.263903725845375 0.386851211489723 no 2057 0.395927052293973 668 6795624 SGTC_650 1328-0195 38 µM -0.264192024193199 0.386731020244253 no 2058 0.395815978288259 680 2780821 SGTC_1334 1486-0610 236 µM -0.264315347023245 0.386679610416659 no 2059 0.395768467727762 640 3742339 SGTC_1035 k081-0041 55.2 µM -0.264837689579993 0.386461882520034 no 2060 0.395567250572193 655 731709 SGTC_1596 piperlongumine 63 µM -0.265211891874424 0.386305925855304 no 2061 0.395423117218709 670 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2172 5754775 163.918 µM -0.265952398305369 0.38599735840501 no 2062 0.395137934861379 654 2263357 SGTC_808 0711-0032 135 µM -0.26606413104812 0.385950805865629 no 2063 0.395094909443171 685 4252555 SGTC_2022 5136654 200 µM -0.267240454912386 0.385460799865268 no 2064 0.394642014957046 694 1713771 SGTC_1787 fluconazole 80 µM -0.267309181988597 0.38543217676081 no 2065 0.394615558855967 668 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3013 9080133 71.4286 µM -0.2673498187932 0.385415252843889 no 2066 0.394599916175447 656 17050193 SGTC_2760 etidronate 98.04 µM -0.267465770321809 0.385366963976001 no 2067 0.394555282874031 644 3305 A chelator and antioxidant. SGTC_3343 9148379 18.9835 µM -0.268447174224549 0.3849583223403 no 2068 0.394177565890495 668 1955036 SGTC_2057 5236571 38.335 µM -0.268559487626354 0.384911564888293 no 2069 0.394134345705089 667 54684039 YBR257W POP4 SGTC_3002 9075603 71.4286 µM -0.26865058794332 0.384873639933958 no 2070 0.394099289647806 652 20105405 SGTC_185 k048-0037 25.491 µM -0.269099651935193 0.3846867112275 no 2071 0.393926499136679 650 6827589 SGTC_2150 5556613 200 µM -0.269663798034392 0.384451916095397 no 2072 0.393709457012205 654 743190 SGTC_1568 digitonin 820 nM -0.269988240963295 0.384316903562892 no 2073 0.393584650071494 695 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_561 1550-0330 72.9 µM -0.270859010691692 0.38395461394821 no 2074 0.393249735819593 688 6812934 SGTC_1781 st038725 66.3 µM -0.271556913968767 0.383664319764252 no 2075 0.392981366231585 648 4270275 YIL048W NEO1 SGTC_2718 lomofungin 53.02 µM -0.271591401584755 0.383649976266745 no 2076 0.392968105787061 682 5351222 A RNA synthesis inhibitor. SGTC_2352 9027995 87.8 µM -0.273595628461767 0.38281668706636 no 2077 0.392197696921988 664 2997347 SGTC_522 1273-0010 11.6 µM -0.275216951594753 0.382142992628962 no 2078 0.391574782090017 637 5705015 SGTC_927 2425-1185 123 µM -0.275254242230184 0.382127501760742 no 2079 0.39156045823423 674 730375 SGTC_766 1391-0721 126 µM -0.275351007583975 0.382087305435149 no 2080 0.39152328999124 698 1020919 YIL115C NUP159 SGTC_2239 6685329 187.64 µM -0.276293734233674 0.381695763375145 no 2081 0.391161234022381 664 805680 SGTC_2428 5615643 7.78 µM -0.276681807977839 0.381534620090481 no 2082 0.391012220940335 679 2253075 SGTC_1791 st048313 56.1 µM -0.277084058263643 0.381367611825467 no 2083 0.390857781217364 632 1204976 SGTC_3158 9100007 49.47 µM -0.278406902879726 0.380818542562783 no 2084 0.390350010585989 667 19297233 SGTC_1400 3771-8998 51.5 µM -0.278705282671541 0.380694728054739 no 2085 0.390235504055157 652 670767 SGTC_405 ebelactone b 50 µM -0.281510637922049 0.379531227915039 no 2086 0.389159384991178 659 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2271 7849410 118.62 µM -0.282150572687999 0.379265972057316 no 2087 0.38891402819821 707 972430 SGTC_2429 5902844 64.44 µM -0.282174706002551 0.379255969800409 no 2088 0.38890477613273 684 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1208 2323-2347 50.3 µM -0.283071391919844 0.378884388064306 no 2089 0.388561055506328 694 5412760 SGTC_1342 1486-1464 234 µM -0.287211074524082 0.377170382125562 no 2090 0.386975353574293 672 3253938 SGTC_3245 9134821 49.47 µM -0.287257799917952 0.377151049543845 no 2091 0.386957466158476 685 17014901 SGTC_3234 9132280 49.47 µM -0.287281904256983 0.377141076519757 no 2092 0.386948238629004 667 17612295 SGTC_2376 9072922 81.32 µM -0.287349005211559 0.377113314338369 no 2093 0.386922551638661 713 17087968 SGTC_3083 9117465 49.47 µM -0.287475119452215 0.377061137866293 no 2094 0.386874275047532 721 16420915 SGTC_60 0986-0278 202 µM -0.288179451822269 0.37676978005029 no 2095 0.386604688484892 720 3110598 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.288411993255748 0.376673601143461 no 2096 0.386515694153936 672 94937 An inhibitor of serotonin biosynthesis. SGTC_790 1575-0012 79.1 µM -0.288619766636173 0.376587672753481 no 2097 0.386436183682655 690 378741 YLR208W SEC13 SGTC_415 dibenzyl ketone 100 µM -0.288631430938512 0.376582848954287 no 2098 0.386431720142561 691 7593 SGTC_2315 7733312 200 µM -0.291008724193075 0.375600117039902 no 2099 0.385522323596012 674 726316 SGTC_2247 cerulenin 830 nM -0.29106972000814 0.375574913010693 no 2100 0.385498998851143 650 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2270 7924575 90.91 µM -0.291432142868007 0.375425167521091 no 2101 0.38536041721806 698 1262135 SGTC_2065 5221596 34.26 µM -0.291515261752014 0.375390827194381 no 2102 0.385328636653443 666 788581 SGTC_2951 9072950 58.06 µM -0.291824937445392 0.375262894270808 no 2103 0.38521023871161 673 16488155 SGTC_2824 7998404 51.95 µM -0.292708749931107 0.374897850002012 no 2104 0.384872390605938 665 837851 SGTC_1763 st044482 94.5 µM -0.29305534031635 0.374754727089621 no 2105 0.384739926043981 670 88505 SGTC_3077 9117319 49.47 µM -0.293338972149362 0.374637615456131 no 2106 0.384631533835164 679 17154678 SGTC_307 1501-1223 22.3 µM -0.293899323911351 0.3744062801097 no 2107 0.384417417372353 695 2830329 SGTC_3289 9119912 71.43 µM -0.294297729850604 0.374241829888467 no 2108 0.38426520360114 731 17014829 SGTC_2688 kanamycin b 96.69 µM -0.296927533689358 0.37315689966855 no 2109 0.383260917394353 681 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3329 9141233 27.5565 µM -0.297494341004609 0.372923193663338 no 2110 0.383044563882694 714 4909101 YNL103W MET4 SGTC_2941 9056145 11.23 µM -0.297554133355665 0.372898542804842 no 2111 0.383021742934951 703 2119517 SGTC_1569 carminic acid 40.6 µM -0.29793516510678 0.372741465379598 no 2112 0.382876324080289 652 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_438 sphingosine 6.67 µM -0.298365255997209 0.372564189121088 no 2113 0.38271220188474 668 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2830 7992007 71.43 µM -0.298548913867978 0.372488496646336 no 2114 0.382642124664625 661 1952075 SGTC_2222 6885208 172.143 µM -0.299063144587038 0.372276588589415 no 2115 0.382445933214327 653 609514 SGTC_2203 7227154 166.4 µM -0.300536773506117 0.371669538900442 no 2116 0.381883875428248 670 896304 SGTC_232 clozapine 119 µM -0.300645993971696 0.371624559078553 no 2117 0.381842227470413 674 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_616 4092-0450 108 µM -0.301794888676861 0.371151520717651 no 2118 0.381404213777219 679 787165 SGTC_2928 9011484 9.79 µM -0.301966725810494 0.37108078633726 no 2119 0.381338714272208 696 2994751 SGTC_2359 9039622 200 µM -0.301971970593918 0.371078627463155 no 2120 0.381336715161027 672 6463596 SGTC_446 go6976 132 µM -0.302773546083253 0.370748728194044 no 2121 0.381031222439767 693 3501 A protein kinase C inhibitor. SGTC_215 1287-0124 461.5 µM -0.304482250807208 0.370045804943194 no 2122 0.380380256515541 684 5560863 SGTC_2238 6671620 73.2395 µM -0.304772516027722 0.369926439313581 no 2123 0.380269707654922 670 729941 SGTC_2403 6032726 181.2 µM -0.306156921212556 0.369357303598854 no 2124 0.37974258518928 680 2881040 SGTC_686 1319-0111 510 µM -0.307785064995544 0.368688332031911 no 2125 0.379122943349776 725 4562600 SGTC_1961 st076550 68.7 µM -0.308310315496889 0.368472601906522 no 2126 0.378923108742487 681 1579337 SGTC_659 k018-0002 107 µM -0.308378286116283 0.368444688139926 no 2127 0.378897251288707 687 6797879 YHR007C ERG11 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.311444440682224 0.367186222292413 no 2128 0.377731386897975 670 23665772 A membrane-active detergent. SGTC_2724 maprotiline 69.64 µM -0.313117578210874 0.366500103604495 no 2129 0.377095667320926 673 4011 A tricyclic antidepressant. SGTC_3147 9097027 49.47 µM -0.314631070183035 0.365879819476686 no 2130 0.376520892895998 670 25236841 SGTC_1531 st059297 52.4 µM -0.314989628292567 0.365732920589586 no 2131 0.376384764378432 675 7566702 SGTC_3089 9117425 49.47 µM -0.315025124115192 0.365718379256278 no 2132 0.37637128903423 718 9401657 SGTC_1298 1079-1278 263 µM -0.315469650600765 0.365536289445623 no 2133 0.37620254539425 720 2840950 SGTC_1687 st020778 55.3625 µM -0.318659574453053 0.364230503318665 no 2134 0.374992336303526 678 4259299 SGTC_106 0092-0003 11.579 µM -0.318667361664064 0.364227317566683 no 2135 0.37498938345284 689 1072148 SGTC_2850 9015429 58.44 µM -0.320198234624449 0.363601219108575 no 2136 0.374409030686275 670 6457570 SGTC_2375 9072683 200 µM -0.321436193828309 0.363095183081489 no 2137 0.373939929231526 725 16798029 SGTC_2821 7996764 71.43 µM -0.321880907453367 0.362913457409355 no 2138 0.373771458862371 645 2987135 SGTC_2233 sulbentine 40.3845 µM -0.323427889723712 0.362281546559979 no 2139 0.373185605316374 688 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2442 5158906 48.48 µM -0.323560249358871 0.362227497731902 no 2140 0.373135493342137 662 1893835 SGTC_3354 9151612 71.43 µM -0.32477632295247 0.361731044850957 no 2141 0.372675182753412 707 27261949 SGTC_1336 1486-0901 104 µM -0.324792531902724 0.361724429238357 no 2142 0.372669048535568 671 5006114 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.325124592645515 0.361588909187595 no 2143 0.372543388473429 700 4213774 SGTC_1707 st032323 6.317 µM -0.325550191109422 0.361415240071608 no 2144 0.37238235124358 694 3132057 YMR211W DML1 SGTC_855 0428-0020 25 µM -0.327753777996365 0.360516504804202 no 2145 0.371548919138391 677 6812414 SGTC_313 3474-0040 5.03 µM -0.328009149048041 0.360412401142929 no 2146 0.371452372525251 681 1043375 YIL048W NEO1 SGTC_1 0258-0098 57.368 µM -0.33044441766273 0.359420168946016 no 2147 0.370532092082649 662 6790032 YDR047W HEM12 SGTC_2731 amoxapine 43.43 µM -0.330518914479431 0.35938983066592 no 2148 0.370503951611448 701 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1309 pyrazolanthrone 13.4 µM -0.332498645021282 0.358583925291859 no 2149 0.369756381339334 687 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2601 securinine 100 µM -0.333185049867084 0.358304651503631 no 2150 0.369497301257671 680 442872 A GABA receptor antagonist. SGTC_170 4197-0004 226 µM -0.333337517836937 0.358242627974817 no 2151 0.369439761021389 680 218692 SGTC_3109 9122853 49.47 µM -0.333560435663481 0.358151952380703 no 2152 0.369355638816003 707 1234709 SGTC_1272 0839-0021 27 µM -0.334486935706501 0.3577751686029 no 2153 0.36900607378401 705 5027250 SGTC_2589 lobaric acid 100 µM -0.334766313240082 0.357661580102617 no 2154 0.36890068691888 690 73157 A novel microtubule depolymerizer. SGTC_3113 9123498 49.47 µM -0.336267556578233 0.357051425059442 no 2155 0.368334556478037 707 8897275 SGTC_815 1582-0027 36.9 µM -0.336949020677947 0.35677457595647 no 2156 0.368077665328873 683 3128206 SGTC_2768 sulfasalazine 50.2 µM -0.337077661081973 0.356722323436781 no 2157 0.368029178440606 743 5384001 An antioxidant and salicylic acid derivative. SGTC_21 0849-0113 22.993 µM -0.337800185165704 0.356428890945384 no 2158 0.367756885169672 687 1560156 SGTC_1766 st045414 44.774 µM -0.338249381511559 0.356246505521186 no 2159 0.367587632756399 681 253960 SGTC_2855 9016525 58.44 µM -0.338537920214305 0.356129368628372 no 2160 0.367478927998854 687 43811474 SGTC_2866 9034245 58.44 µM -0.3397702497799 0.355629237704918 no 2161 0.367014776837954 694 6462273 SGTC_1404 3909-7820 48.3 µM -0.34009885134021 0.355495919357236 no 2162 0.366891043386432 707 23741373 SGTC_2786 7743617 45.45 µM -0.340215733924386 0.355448502684589 no 2163 0.366847035104089 700 583674 SGTC_2165 5727197 32.143 µM -0.340252088240514 0.355433755000787 no 2164 0.366833347442068 700 1361712 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.340550052929476 0.355312889231524 no 2165 0.366721167971435 729 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1925 st057770 10.1 µM -0.34097452557958 0.355140732173334 no 2166 0.366561379711011 702 5989122 SGTC_2531 methyl deoxycholate 70.07 µM -0.342213282729357 0.354638487829953 no 2167 0.366095194935254 726 16667744 Haematoxylin. SGTC_2622 2-methoxyxanthone 59.94 µM -0.34241479831306 0.354556808786743 no 2168 0.366019376707835 682 71034 A hepatoprotective. SGTC_3355 9151058 44.0485 µM -0.342662157274612 0.354456557478545 no 2169 0.365926317519221 686 17015728 SGTC_760 0568-0725 82.9 µM -0.343174513148499 0.354248938511906 no 2170 0.365733588643046 712 3916171 SGTC_395 anisomycin 6.25 µM -0.343746798043337 0.354017086069959 no 2171 0.365518356801682 713 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1623 st003709 20.3 µM -0.345174398509397 0.353438951689425 no 2172 0.364981632177875 659 16192618 SGTC_478 N-arachidonylglycine 10 µM -0.345674641272016 0.353236448617374 no 2173 0.364793622034787 679 5283389 SGTC_1822 st052468 42 µM -0.346467903779232 0.352915413539561 no 2174 0.364495550657692 685 2873678 SGTC_586 0957-0265 8.15 µM -0.347119872235683 0.35265163883768 no 2175 0.364250632370827 707 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3031 9088762 49.47 µM -0.348166480544639 0.352228348108083 no 2176 0.363857579721547 708 205253 SGTC_2992 9074591 71.4286 µM -0.348435312668311 0.352119651043073 no 2177 0.363756643200367 711 17741321 SGTC_987 1497-1013 404 µM -0.349018282807785 0.35188397986747 no 2178 0.363537791960078 716 1676435 SGTC_2440 5628896 157.78 µM -0.350397050727151 0.351326826474362 no 2179 0.363020369727581 696 5522048 SGTC_2153 5569715 200 µM -0.350802190717943 0.351163172028768 no 2180 0.362868376786816 700 2054701 SGTC_1067 clotrimazole 1.36 µM -0.351256201437513 0.350979809268216 no 2181 0.362698075095304 687 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_257 daunorubicin 18.5 µM -0.351351436831858 0.35094135064595 no 2182 0.362662355267265 694 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_471 1-acyl-paf 4 µM -0.351611695749142 0.350836258861034 no 2183 0.362564746356331 686 16759367 SGTC_552 k242-0005 476 µM -0.351728712084026 0.350789011727523 no 2184 0.362520862828054 730 4088318 SGTC_295 k015-0027 31 µM -0.351809674248858 0.350756323366637 no 2185 0.362490501410935 701 3887424 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.35244088749959 0.350501509798866 no 2186 0.362253821389642 709 4620898 SGTC_950 1165-0508 94.1 µM -0.352885160987997 0.350322201995859 no 2187 0.362087267953963 696 6148369 SGTC_899 1083-0020 478 µM -0.353478133708359 0.350082931483176 no 2188 0.361865009433458 738 767123 SGTC_382 3229-0966 23.2 µM -0.353495079563705 0.350076094532618 no 2189 0.361858658458373 735 5722370 SGTC_2913 7966556 36.57 µM -0.353938322994678 0.349897281437473 no 2190 0.361692553007656 714 2976516 SGTC_2868 9035608 32.47 µM -0.356237179752744 0.348970412279283 no 2191 0.360831475229172 676 6462614 SGTC_2135 5326629 150.42 µM -0.357311613820586 0.348537522831926 no 2192 0.360429268264698 688 5020077 SGTC_741 4582-0002 126 µM -0.358176072152894 0.34818937570104 no 2193 0.360105776318951 668 2912688 SGTC_1354 1498-1681 81 µM -0.359617692002137 0.347609070352131 no 2194 0.359566525630997 712 5754243 SGTC_1134 3477-0009 42.5 µM -0.359875051205553 0.347505511253387 no 2195 0.359470287512038 718 3973534 SGTC_856 0433-0016 11.3 µM -0.361813859095265 0.346725718151711 no 2196 0.358745567388734 707 3911780 SGTC_1954 st077032 68.9 µM -0.36252281324039 0.346440736968589 no 2197 0.358480689387904 750 698907 SGTC_967 1306-0166 352 µM -0.362998863965147 0.34624942567742 no 2198 0.358302866479445 678 4437607 SGTC_883 0850-0245 24.6 µM -0.364337188369073 0.345711801316314 no 2199 0.357803116540574 724 6823229 YPR165W RHO1 SGTC_421 streptovitacin 30 mM -0.364567511672526 0.345619308435142 no 2200 0.357717134994194 716 91467 include heat shock SGTC_2490 carminic acid 95.39 µM -0.364673955844436 0.345576565859995 no 2201 0.357677400965483 716 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2216 7189485 200 µM -0.365328239023048 0.345313882213336 no 2202 0.357433200662271 699 731273 SGTC_2683 piperine 63.03 µM -0.366988021180724 0.344647842146678 no 2203 0.356813976637199 727 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_122 0236-0016 402.397 µM -0.368150028456487 0.344181836261056 no 2204 0.356380684525704 711 6808838 SGTC_2926 9010726 65.15 µM -0.369315472514728 0.343714689644127 no 2205 0.355946297041507 738 2994293 SGTC_2733 amorolfine 100 µM -0.369718037104686 0.343553384492957 no 2206 0.355796295480486 713 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_974 1326-0144 138 µM -0.369763613476027 0.343535124116254 no 2207 0.355779314452201 722 5411856 SGTC_551 k048-0028 34.9 µM -0.369825202841989 0.343510448641874 no 2208 0.35575636769244 739 6836383 SGTC_3141 9094609 49.47 µM -0.370474330643521 0.343250419376576 no 2209 0.355514549627717 719 25236309 YDL196W YDL196W SGTC_2938 9059746 27.26 µM -0.370546728556954 0.343221422632985 no 2210 0.35548758300463 729 6471769 SGTC_2161 5662504 8.5105 µM -0.37260285820984 0.342398289459351 no 2211 0.354722022625997 669 2859334 SGTC_678 1218-2179 85.9 µM -0.373340560228616 0.342103146341218 no 2212 0.354447496214298 711 6820081 YOR116C RPO31 SGTC_2350 9023895 38.85 µM -0.374459571504277 0.341655631454681 no 2213 0.354031214771331 696 2997209 SGTC_1189 1431-2119 7.28 µM -0.376270949172504 0.340931697191371 no 2214 0.35335773713684 727 3107275 SGTC_265 mycophenolic acid 32.932 µM -0.377746908012258 0.340342248846902 no 2215 0.352809308787367 729 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2317 5986382 200 µM -0.377828866815238 0.340309528668824 no 2216 0.352778863952869 719 877883 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.378118975221221 0.340193719182058 no 2217 0.352671106382176 753 688798 SGTC_1572 epiandrosterone 68.9 µM -0.380199328091378 0.339363697310015 no 2218 0.351898728983724 694 441302 A steroid. SGTC_609 0986-0026 86.3 µM -0.380426240568435 0.33927321050916 no 2219 0.351814519551427 712 2848610 SGTC_828 2074-0507 139 µM -0.382891024002307 0.338290916970452 no 2220 0.350900283480941 704 X828 SGTC_1037 k284-1091 78.7 µM -0.385816275854422 0.337126539418223 no 2221 0.349816370223419 713 3334711 SGTC_3314 9135860 59.4275 µM -0.386186391545517 0.336979328113851 no 2222 0.349679315733618 712 25252478 SGTC_3203 9113543 49.47 µM -0.386955385972028 0.336673545019021 no 2223 0.349394618396318 698 17018012 SGTC_765 1319-0117 244 µM -0.387551173192303 0.336436710277199 no 2224 0.349174104107803 690 3487746 YGL099W LSG1 SGTC_2257 7960413 200 µM -0.389830184490424 0.335531367079596 no 2225 0.348331061037924 704 2974689 YIL048W NEO1 SGTC_2301 7769476 200 µM -0.390068732679156 0.335436658256864 no 2226 0.348242861430346 712 977820 SGTC_3210 9128157 49.47 µM -0.390077599003534 0.335433138334625 no 2227 0.348239583398315 724 17590849 SGTC_788 1182-0090 188 µM -0.390805810238536 0.335144088514406 no 2228 0.347970389952711 699 5715185 SGTC_3197 9113331 49.47 µM -0.39213177570309 0.334618022074792 no 2229 0.347480425118112 717 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_26 0302-0163 425.158 µM -0.39414297778393 0.333820712952665 no 2230 0.34673774108332 750 3100915 SGTC_594 1487-1584 10.8 µM -0.395023827190977 0.333471750051943 no 2231 0.346412651727361 750 5013332 SGTC_2507 purpurin 79.67 µM -0.395595589140956 0.333245314283155 no 2232 0.346201695785356 693 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1960 st011366 51.8 µM -0.39683694960247 0.332753905650176 no 2233 0.345743850670309 698 3972846 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.397021795612115 0.332680756505945 no 2234 0.345675694063378 685 6708514 SGTC_972 1319-0219 195 µM -0.397516281403608 0.332485104872825 no 2235 0.345493391356272 729 23903702 SGTC_1848 st056003 16.4 µM -0.397784469856482 0.332379010674875 no 2236 0.345394532961593 691 146492 SGTC_1849 st056239 19.2 µM -0.399383233259164 0.331746825646502 no 2237 0.34480542316984 744 5393181 SGTC_1452 4194-0072 190 µM -0.400200153716718 0.331423982663322 no 2238 0.344504550703443 735 1343545 SGTC_110 0850-0284 111.64 µM -0.400888768151468 0.331151942845302 no 2239 0.344251009833989 710 3906265 SGTC_1322 1348-1070 12 µM -0.401417002429459 0.330943322212181 no 2240 0.34405656674241 725 6758089 SGTC_2685 mycophenolic acid 18.85 µM -0.403391727914857 0.330163890199566 no 2241 0.343330035586517 695 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2095 5432005 200 µM -0.404159036378907 0.329861228985124 no 2242 0.343047887219509 755 783734 SGTC_1563 conessine 56.1 µM -0.404753308851169 0.329626897509526 no 2243 0.342829426335402 734 441082 An anti-amoebic, histamine inhibitor. SGTC_2845 9003024 42.97 µM -0.405377877186893 0.329380691945077 no 2244 0.34259988499766 704 2990173 SGTC_2367 9070478 135.38 µM -0.405665746077438 0.329267238586122 no 2245 0.342494106990141 699 572802 SGTC_74 000s-0487 160.283 µM -0.405836351545649 0.32920000788274 no 2246 0.342431423493825 712 677548 SGTC_3174 9107204 49.47 µM -0.406465566626928 0.328952100096429 no 2247 0.342200276165517 739 3938802 SGTC_1153 4055-0057 267 µM -0.406763261999332 0.328834835725238 no 2248 0.342090935919207 720 882706 SGTC_2761 levamisole 97.89 µM -0.40744456820705 0.328566527672963 no 2249 0.341840749453886 750 26879 An alkaline phosphatase inhibitor. SGTC_983 1491-0821 12.2 µM -0.407587037548237 0.328510432391357 no 2250 0.341788441223456 703 46495113 SGTC_2735 sertaconazole 140 nM -0.408514751449306 0.328145252777826 no 2251 0.341447901405082 715 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1079 idarubicin 2.36 µM -0.409058095246281 0.327931450473204 no 2252 0.34124851382886 738 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_94 0334-0113 514.748 µM -0.410590925741541 0.32732859554876 no 2253 0.340686259312878 709 6795178 SGTC_884 0851-0618 334 µM -0.411988404632146 0.326779365904741 no 2254 0.340173961098906 748 9642473 SGTC_3137 9097352 49.47 µM -0.412968180091863 0.326394523425081 no 2255 0.339814963505292 782 44120435 SGTC_1078 idebenone 36.1 µM -0.412983951238836 0.326388330242629 no 2256 0.339809186017321 718 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_823 0417-1665 178 µM -0.413076679786068 0.326351917574279 no 2257 0.339775217272775 753 3429856 SGTC_2313 7726885 200 µM -0.413241259285164 0.326287294532109 no 2258 0.3397149309638 716 726423 SGTC_1277 0873-0036 22 µM -0.414569300773714 0.325766022722154 no 2259 0.339228612742285 731 5965735 SGTC_1746 st038117 42 µM -0.41518748231043 0.325523495299409 no 2260 0.339002330840098 725 2898218 SGTC_2567 aureobasidin a 60 nM -0.415956460587441 0.325221909780026 no 2261 0.3387209316869 698 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_770 0389-1121 67.2 µM -0.416038371297845 0.325189791967306 no 2262 0.338690962663406 708 6753108 SGTC_544 k015-0020 52.4 µM -0.416129811884589 0.325153938951665 no 2263 0.338657508109532 724 3008304 SGTC_2345 9052315 157.45 µM -0.416675055715111 0.324940187457447 no 2264 0.338458051033951 716 6469265 SGTC_2875 9039966 71.43 µM -0.418361895414278 0.324279262163599 no 2265 0.337841270916348 729 6463691 SGTC_3016 9080866 49.47 µM -0.418825851200433 0.324097575299564 no 2266 0.337671705243326 754 17066299 SGTC_2008 4012253 172 µM -0.419324438767058 0.323902373190817 no 2267 0.337489519141182 703 603940 SGTC_97 0535-0701 19.132 µM -0.420501640948458 0.323441678748457 no 2268 0.337059515443413 701 2832013 YGL099W LSG1 SGTC_767 0929-0023 86 µM -0.422277782507033 0.322747103391751 no 2269 0.33641113648298 714 1204563 SGTC_2990 9074105 71.4286 µM -0.422709988678961 0.322578178857948 no 2270 0.336253433463157 743 6502001 SGTC_2922 7999257 32.47 µM -0.423512203188031 0.322264736420456 no 2271 0.335960798496476 726 2988377 SGTC_3156 9099931 49.47 µM -0.425309234160487 0.321563056566248 no 2272 0.335305631440967 697 18111053 SGTC_1983 st071813 46.9 µM -0.425686192884601 0.321415947559088 no 2273 0.335168262129072 723 11838595 SGTC_120 rhodamine 6G 52.259 µM -0.42675049059115 0.321000754164739 no 2274 0.334780535386065 759 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3213 9129884 49.47 µM -0.426984534852619 0.320909481099346 no 2275 0.334695295985297 744 17190742 SGTC_180 1486-1293 102.781 µM -0.427169205328894 0.320837470562955 no 2276 0.334628044630317 738 4140536 SGTC_1313 1220-0047 237 µM -0.427647894649105 0.320650841494301 no 2277 0.334453745282489 726 3528706 SGTC_291 SEC14.278 35.5 µM -0.428651551682468 0.320259687753635 no 2278 0.334088411655936 722 1068044 SGTC_797 k781-0471 270 µM -0.428671523650391 0.320251906133184 no 2279 0.334081143404125 699 23738129 SGTC_159 3970-0959 50 µM -0.431196218665142 0.31926885403325 no 2280 0.333162851579646 714 6615653 SGTC_2734 clemastine 41.6 µM -0.431715230754778 0.319066920971375 no 2281 0.332974198152401 743 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2441 5730946 39.09 µM -0.431896331051527 0.318996472550585 no 2282 0.332908380745037 704 1774275 SGTC_564 3555-0129 330 µM -0.432575729726927 0.318732243231417 no 2283 0.332661512304769 721 563260 SGTC_895 0964-0006 13.7 µM -0.432785596444613 0.318650641231671 no 2284 0.33258526913469 734 6738897 SGTC_1156 4092-0367 4.88 µM -0.433168278765011 0.3185018663725 no 2285 0.332446261043432 736 1357585 SGTC_1032 k061-1018 98.7 µM -0.434594737065504 0.317947562178796 no 2286 0.331928307913866 762 4005393 SGTC_1045 1348-1485 165 µM -0.434916617716475 0.317822539631697 no 2287 0.331811476026493 735 6810614 SGTC_2083 5306046 65.942 µM -0.43790987741041 0.316660915389402 no 2288 0.330725807559967 737 539837 SGTC_2248 tofa 1.1 µM -0.438164611570916 0.316562141373018 no 2289 0.330633479911712 743 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_763 3453-1109 128 µM -0.438547388028479 0.316413743127632 no 2290 0.330494763086335 757 1560353 SGTC_2333 9017922 200 µM -0.440181453742609 0.315780566358018 no 2291 0.329902845554302 719 3163164 SGTC_1709 st033179 39.1045 µM -0.441014575022306 0.315457951748308 no 2292 0.329601222713975 720 573381 SGTC_3104 9120930 49.47 µM -0.442403513569227 0.314920417368387 no 2293 0.329098618473933 751 17014836 SGTC_63 0099-0242 26.702 µM -0.442860911395378 0.314743485120646 no 2294 0.32893317106873 749 3898502 YLR359W ADE13 SGTC_2263 7948595 193.29 µM -0.444775688048379 0.314003266392165 no 2295 0.328240932764187 714 2971371 SGTC_169 k015-0017 16.025 µM -0.445197525329374 0.313840291981841 no 2296 0.328088507474791 789 1840002 SGTC_2933 9026794 32.47 µM -0.445197866578809 0.313840160156778 no 2297 0.328088384180432 749 17586027 SGTC_2423 st077119 87.2 µM -0.445555567899576 0.313701992780243 no 2298 0.327959156011802 715 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.445736302541493 0.313632191310502 no 2299 0.327893869124787 733 16623 A steroid. SGTC_1554 st069299 38.7 µM -0.445740094334972 0.313630726954571 no 2300 0.327892499469194 726 24207999 SGTC_1862 st057513 3.81 µM -0.446477951840951 0.313345829049456 no 2301 0.327626017777273 725 5393163 SGTC_2978 9011784 42.97 µM -0.447919391862845 0.312789588670101 no 2302 0.327105686344335 717 2994934 SGTC_3041 9091929 49.47 µM -0.449813789099443 0.312059203597706 no 2303 0.326422357150711 736 25236887 SGTC_234 nsc-17383 10.7 µM -0.450509014716514 0.311791344296959 no 2304 0.32617172778214 734 408974 SGTC_1299 1079-1439 3.74 µM -0.45084262297288 0.311662845706325 no 2305 0.326051489610942 761 323161 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.45250049920951 0.311024608470737 no 2306 0.325454230845274 750 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2283 7944793 200 µM -0.453451226136784 0.31065886056638 no 2307 0.325111928379392 718 2970533 SGTC_1372 2752-0194 270 µM -0.454085922603472 0.310414794756384 no 2308 0.32488349254164 749 823334 SGTC_3351 9150312 21.596 µM -0.454444387120627 0.31027698788749 no 2309 0.32475450539946 746 4904905 SGTC_1430 4049-0248 69.1 µM -0.454734735452385 0.310165386893463 no 2310 0.324650044067319 756 22774488 SGTC_142 0335-0849 62.6745 µM -0.455608730874577 0.309829555405343 no 2311 0.324335681835323 721 3889043 YPR107C YTH1 SGTC_1613 st002381 52.1 µM -0.45564927457262 0.30981398039582 no 2312 0.324321101949009 728 551167 SGTC_2923 7992654 58.14 µM -0.455667527112821 0.30980696872735 no 2313 0.324314538255777 712 2985126 SGTC_1344 1488-0097 29.1 µM -0.457046422869342 0.309277469521628 no 2314 0.323818839278833 759 747966 SGTC_1097 itavastatin 7.23 µM -0.457194722364071 0.309220545724563 no 2315 0.323765545708131 726 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3127 9126946 49.47 µM -0.45741588090919 0.309135663961456 no 2316 0.323686075895138 754 27243249 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.45989830152435 0.30818359825932 no 2317 0.322794609699548 704 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1397 3532-0190 20.1 µM -0.460314224332824 0.308024208160919 no 2318 0.322645346339771 719 5322280 SGTC_1159 4092-0538 61.2 µM -0.46082416327011 0.307828838572017 no 2319 0.322462382148998 738 717301 SGTC_587 k089-0003 57 µM -0.461212536408865 0.307680080231629 no 2320 0.322323064150703 739 9659696 SGTC_273 hydroxyurea 18.1 mM -0.462976953539575 0.307004654893038 no 2321 0.321690443303337 753 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1679 SEC14.276 6.7 µM -0.463211156203869 0.30691505040667 no 2322 0.321606510187603 723 1005053 YMR079W SEC14 SGTC_1714 st033236 13.627 µM -0.463629856556381 0.306754886992094 no 2323 0.321456479824674 759 2916566 SGTC_266 formosanin C 406 nM -0.463718895337652 0.306720832174244 no 2324 0.321424578851303 736 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2812 7970281 58.44 µM -0.464784344746851 0.306313457371738 no 2325 0.32104294997211 758 2233435 SGTC_840 0245-0196 390 µM -0.464812894454773 0.306302544675077 no 2326 0.321032726469021 722 3827528 SGTC_2228 7354201 200 µM -0.464907221893888 0.306266490651236 no 2327 0.320998949264456 743 753451 SGTC_2041 5107442 45.335 µM -0.465933571370185 0.305874318598736 no 2328 0.320631525098024 749 793005 SGTC_1229 0139-0193 12.2 µM -0.466532465348514 0.305645581676688 no 2329 0.32041720741249 738 3090752 SGTC_324 1315-0088 19.6 µM -0.466707758768271 0.305578645807365 no 2330 0.320354488969216 764 6787421 SGTC_1815 st051655 58.2 µM -0.467288836941167 0.305356807327222 no 2331 0.32014662101401 753 5984156 SGTC_2797 7859098 81.82 µM -0.468857135461623 0.304758434167631 no 2332 0.319585878517415 736 972681 SGTC_2384 9036245 200 µM -0.472955372479115 0.303197247707294 no 2333 0.318122509303827 750 6462766 SGTC_525 k781-2675 26.7 µM -0.472965190162428 0.303193512046104 no 2334 0.318119007070241 735 3651118 YDL195W SEC31 SGTC_429 1112-0049 25.5 µM -0.474127621827721 0.302751348497741 no 2335 0.317704451232328 719 2836170 SGTC_78 0336-0123 156.75 µM -0.475592585790353 0.302194520035604 no 2336 0.317182329240862 733 6765896 SGTC_2841 9004761 38.96 µM -0.478341656752037 0.301150848990883 no 2337 0.316203525936376 723 2991039 SGTC_3309 9129340 25.759 µM -0.478662648218007 0.301029092141143 no 2338 0.316089321077255 731 17158987 SGTC_2475 5812728 15.03 µM -0.479501260338022 0.300711098823153 no 2339 0.315791035908198 741 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2691 st077356 60.2 µM -0.479772074374583 0.300608441243736 no 2340 0.315694735922386 754 2839272 SGTC_2900 5328528 85.29 µM -0.479980611670275 0.300529401716214 no 2341 0.315620589730188 741 795359 SGTC_1681 tripelennamine 100 µM -0.481347893605952 0.300011408999008 no 2342 0.315134631630977 716 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2130 NSC 7 2.4545 µM -0.481602661178659 0.299914935349297 no 2343 0.315044117689051 757 21448 SGTC_288 1315-0019 35.1 µM -0.481996053109296 0.299765995958302 no 2344 0.314904375035036 753 6811474 SGTC_1294 1000-1494 117 µM -0.483187681573717 0.299315046303522 no 2345 0.314481240543962 723 712797 YDL207W GLE1 SGTC_1483 3453-0561 55.9 µM -0.484325372537936 0.298884795660135 no 2346 0.31407748594943 767 4546991 SGTC_3107 9121808 49.47 µM -0.485092520011538 0.298594835426784 no 2347 0.313805358880363 715 662681 SGTC_2529 gangaleoidin 93.61 µM -0.485286780326255 0.298521430779779 no 2348 0.313736465778471 768 4565183 SGTC_293 4049-0273 38.5 µM -0.485642592280309 0.298387002321634 no 2349 0.313610296327265 752 1380311 SGTC_1341 1486-1360 280 µM -0.48733011640017 0.297749818435851 no 2350 0.313012204316879 776 3976547 SGTC_3291 9121177 71.43 µM -0.487581394258782 0.29765499279063 no 2351 0.312923188484896 757 17015612 SGTC_2411 st077133 39.94 µM -0.487903754859245 0.297533362575605 no 2352 0.31280900737739 786 1403142 YNL221C POP1 SGTC_851 0394-0702 453 µM -0.48897250154125 0.297130275063234 no 2353 0.312430582551065 769 762646 SGTC_732 3970-1727 52.7 µM -0.489314261031807 0.297001430074473 no 2354 0.312309613094935 765 1275699 SGTC_1774 st048371 48.465 µM -0.489578546809364 0.296901810578414 no 2355 0.312216080163528 752 4242727 SGTC_835 0312-0010 67.2 µM -0.49033559513175 0.296616534549461 no 2356 0.311948221472702 756 1626196 SGTC_70 0141-0289 43.283 µM -0.490565372046051 0.29652997331425 no 2357 0.311866941509825 739 352408 SGTC_1492 4158-0558 28.5 µM -0.490723160409902 0.296470538208182 no 2358 0.31181113166782 744 3967268 SGTC_1486 3970-0793 4.53 µM -0.492293935860488 0.295879162565971 no 2359 0.311255783216831 767 2844330 SGTC_3177 9107506 49.47 µM -0.492605990045569 0.295761742933988 no 2360 0.311145507381209 763 8897194 SGTC_2762 leflunomide 42.06 µM -0.492791677313267 0.295691882760137 no 2361 0.311079895991957 773 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_455 paf C-16 10 µM -0.494049276179494 0.295218942481856 no 2362 0.310635689709955 757 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_795 0685-0265 78 µM -0.494899233566493 0.294899499672342 no 2363 0.310335625866068 752 302754 SGTC_1335 1486-0900 202 µM -0.495089052883704 0.294828180902196 no 2364 0.31026863042841 729 X1335 SGTC_375 3970-0961 9.27 µM -0.495809325100663 0.29455763312241 no 2365 0.310014472530113 749 2898222 SGTC_2089 5281248 129.67 µM -0.496607858455868 0.294257822961984 no 2366 0.30973280519761 748 2737878 SGTC_146 3448-8650 53.125 µM -0.496934150111354 0.29413535700653 no 2367 0.309617744202704 785 2891488 YIL048W NEO1 SGTC_776 4476-4378 112 µM -0.496965875893766 0.294123450731247 no 2368 0.309606557660301 790 2892008 SGTC_2878 9043973 25.97 µM -0.497663398350609 0.293861735884425 no 2369 0.309360655130583 755 6465167 SGTC_3231 9132313 49.47 µM -0.498006160843689 0.293733168709025 no 2370 0.309239849910577 765 4905967 SGTC_2701 st077767 14.721 µM -0.499400702472917 0.293210357083621 no 2371 0.308748562207941 755 5721188 SGTC_2956 9076196 2.52 µM -0.499582097584306 0.293142384040891 no 2372 0.308684683044697 793 16423868 SGTC_89 0302-0250 142.109 µM -0.500161494738349 0.292925319171722 no 2373 0.308480684323859 768 4203518 YLR208W SEC13 SGTC_769 0302-0231 76 µM -0.500987943917242 0.29261582808557 no 2374 0.308189803877215 774 571869 YER009W NTF2 SGTC_3170 9103054 49.47 µM -0.501325011788034 0.292489645560934 no 2375 0.3080712026466 779 16432970 SGTC_3003 9075612 71.4286 µM -0.501371043362382 0.292472415444599 no 2376 0.308055007459521 782 6501993 SGTC_3188 9110789 49.47 µM -0.501587151298018 0.292391530213566 no 2377 0.307978979678921 766 849217 SGTC_3056 9094900 49.47 µM -0.502730489755702 0.291963772800842 no 2378 0.307576885064989 760 25236784 SGTC_618 k072-0232 33.2 µM -0.502955292460514 0.291879701618507 no 2379 0.307497852567486 775 5872756 YGL099W LSG1 SGTC_1661 st013063 9.66 µM -0.503955601608494 0.291505745164108 no 2380 0.307146288444512 774 721395 SGTC_2139 5578692 56.4705 µM -0.504632775003601 0.291252716969598 no 2381 0.306908392706705 771 650991 YMR113W FOL3 SGTC_2553 4-methylesculetin 85.09 µM -0.506252263313467 0.290648005685237 no 2382 0.306339784953021 766 5319502 SGTC_2788 5282734 71.43 µM -0.506291659493422 0.29063330260921 no 2383 0.306325958624015 791 743706 SGTC_1014 4130-3005 69.3 µM -0.507217429657307 0.290287895475163 no 2384 0.306001133370341 765 743608 SGTC_1002 4049-0206 172 µM -0.507941088050132 0.290018030698564 no 2385 0.305747329311735 760 4662749 SGTC_3094 9117742 49.47 µM -0.508804638419986 0.289696151773789 no 2386 0.305444583911874 801 17149698 SGTC_1922 5578187 25 µM -0.510137580317816 0.289199641698409 no 2387 0.304977539320411 724 1350412 SGTC_2294 7971431 200 µM -0.510630013257074 0.289016315662437 no 2388 0.304805077835319 801 5741572 SGTC_3028 9087778 49.47 µM -0.511143816303824 0.288825092126385 no 2389 0.304625178264856 735 17217395 SGTC_2113 5491891 107.031 µM -0.511475071684837 0.288701839456599 no 2390 0.304509219759879 778 789979 SGTC_262 fenpropimorph 62.5 µM -0.51230864256882 0.288391796132142 no 2391 0.304217508770106 780 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1803 st050068 52.4 µM -0.512602434939836 0.288282558668803 no 2392 0.304114724798631 763 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1875 nocodazole 6 µM -0.513596785440805 0.287912985533345 no 2393 0.303766963753282 767 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_583 1488-1091 88.9 µM -0.514111288283004 0.287721846636848 no 2394 0.303587092820691 777 4303273 SGTC_612 0302-0167 22.4 µM -0.515762516399556 0.287108817228101 no 2395 0.303010142606026 766 235821 SGTC_1192 1488-0095 21.4 µM -0.515798605957504 0.287095425648812 no 2396 0.302997538152031 791 915875 SGTC_723 4182-0001 115 µM -0.515841689190821 0.287079439347223 no 2397 0.302982491430069 768 744821 YLR208W SEC13 SGTC_2759 disulfiram 3.38 µM -0.51777249893759 0.286363433507621 no 2398 0.302308504096014 750 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_957 1187-1561 14.1 µM -0.518996024599265 0.285910150383077 no 2399 0.301881756744104 766 1538454 SGTC_1057 3448-5381 134 µM -0.519191272145562 0.285837848025915 no 2400 0.301813682388032 754 5497911 SGTC_166 k072-0058 166.424 µM -0.5192444135402 0.28581817067657 no 2401 0.301795155481787 784 5846229 SGTC_2195 6536160 144.242 µM -0.51963307373077 0.285674276044949 no 2402 0.301659670801439 746 3834386 SGTC_1157 4092-0394 27.6 µM -0.519894761776987 0.285577410047421 no 2403 0.301568463283185 770 3659885 SGTC_805 3852-0218 479 µM -0.520626148700465 0.285306764052115 no 2404 0.301313614947373 759 6615355 SGTC_1899 st063254 59.6 µM -0.521711710063818 0.284905283027758 no 2405 0.300935535095251 764 3093813 SGTC_2319 6033012 152.6 µM -0.522015089358923 0.284793130265446 no 2406 0.30082991226096 751 847246 SGTC_3323 9138564 53.9225 µM -0.523130644700566 0.284380914850272 no 2407 0.300441670650737 748 43912313 YNL103W MET4 SGTC_1263 0774-1208 64.8 µM -0.523688316316422 0.284174953275443 no 2408 0.300247671651139 807 906585 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.523756108195235 0.284149920963191 no 2409 0.300224092535373 775 279621 SGTC_1241 0364-0022 50.8 µM -0.525652445594417 0.283450121538715 no 2410 0.299564855150647 775 4563895 SGTC_2214 7179297 48.276 µM -0.525676095886755 0.283441399163941 no 2411 0.299556637572964 745 769744 SGTC_3280 9140961 49.47 µM -0.525824972274046 0.283386495581492 no 2412 0.299504911032748 781 4901226 SGTC_1797 st048695 56.8 µM -0.525871973909116 0.283369163078142 no 2413 0.299488581332543 804 592262 YIL048W NEO1 SGTC_819 1013-0258 27.7 µM -0.526413565756297 0.283169480270224 no 2414 0.299300446101349 780 5753198 SGTC_1162 k048-0130 20.1 µM -0.527480737858863 0.282776215753328 no 2415 0.298929894645912 785 6797406 SGTC_1836 st055642 81 µM -0.527660517509802 0.282709990831079 no 2416 0.298867490730414 783 8571 SGTC_2661 dactinomycin 12.96 µM -0.527749855242602 0.28267708451484 no 2417 0.298836482612975 761 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2513 baicalein 25.65 µM -0.528120438658714 0.282540604904237 no 2418 0.298707872909062 787 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2256 7954252 200 µM -0.530048114124498 0.281831186064951 no 2419 0.298039285993646 782 2972920 SGTC_799 1310-0557 151 µM -0.530535838643702 0.28165183093331 no 2420 0.297870233816769 790 5354492 SGTC_252 miconazole 1.30953 nM -0.531059248570601 0.281459414145708 no 2421 0.297688861231337 778 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2888 9058547 12.99 µM -0.531356140069895 0.281350298620854 no 2422 0.297586004464549 753 16476514 SGTC_2284 7945075 39.21 µM -0.53162268389233 0.281252354071606 no 2423 0.297493675339985 756 1245402 SGTC_2597 laccaic acid a 100 µM -0.532175253655458 0.281049358503732 no 2424 0.297302310283432 770 5491415 A textile dye. SGTC_999 SEC7.066 22.7 µM -0.532245501117314 0.281023557018561 no 2425 0.297277986327607 765 740511 YDR170C SEC7 SGTC_2365 9042475 200 µM -0.53251828946884 0.28092337429275 no 2426 0.297183538985886 761 6464479 SGTC_1686 st019653 115.5 µM -0.532528417351826 0.280919655115406 no 2427 0.297180032679339 800 97252 SGTC_2109 5483026 200 µM -0.534879024265199 0.2800571058873 no 2428 0.296366756865726 800 759335 SGTC_1237 0330-0133 46.1 µM -0.539424898607263 0.278392659786205 no 2429 0.294796852313149 788 X1237 YHR072W ERG7 SGTC_378 3970-0959 8.33 µM -0.540133233615612 0.278133741705373 no 2430 0.294552576519386 797 6615653 SGTC_745 0469-0705 296 µM -0.540805065727286 0.277888275126508 no 2431 0.294320975423359 785 3486736 SGTC_197 4544-0043 41.561 µM -0.542622681533668 0.277224705322468 no 2432 0.293694809534686 780 896523 SGTC_666 0272-0154 136 µM -0.543350358380058 0.276959264654391 no 2433 0.293444298911354 772 6870312 SGTC_2640 pentamidine 10.38 µM -0.545416996083897 0.276206079438909 no 2434 0.292733376842815 790 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_523 1934-0222 13.7 µM -0.54564715387729 0.276122260780726 no 2435 0.292654252230978 803 1361595 SGTC_1759 st043059 70 µM -0.54596452469606 0.276006701445348 no 2436 0.292545161457237 795 669426 SGTC_657 3534-0529 86.7 µM -0.547340777872252 0.275505862598012 no 2437 0.292072316831944 790 1049549 SGTC_3047 9092122 49.47 µM -0.547760625194654 0.2753531629928 no 2438 0.291928139112219 793 17173831 SGTC_2756 carbadox 75.1 µM -0.548565766573063 0.275060447466275 no 2439 0.291651742208242 778 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_985 1493-0307 8.71 µM -0.548974094790097 0.274912055107041 no 2440 0.291511613891912 784 3278274 SGTC_559 1550-0661 158 µM -0.549857397612028 0.274591185168193 no 2441 0.291208593318723 768 5830875 SGTC_3273 9137859 49.47 µM -0.550724107464404 0.274276522491298 no 2442 0.290911408047671 804 2377234 SGTC_1049 3226-0134 66 µM -0.550724759402269 0.27427628586953 no 2443 0.290911184558709 769 5702385 SGTC_2223 6903751 107.57 µM -0.551774851807035 0.273895284241446 no 2444 0.290551309574684 784 5598863 SGTC_2534 helenine 20.12 µM -0.552119917289095 0.273770142390594 no 2445 0.290433098392103 771 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1621 st003705 32.4 µM -0.55228672356068 0.273709658373746 no 2446 0.290375962625775 765 24207032 SGTC_653 0203-0016 55.2 µM -0.555939734483188 0.272386735104911 no 2447 0.289126026958229 777 295302 SGTC_1857 st056007 79.3 µM -0.557972689193174 0.271651886805326 no 2448 0.288431516810945 768 619834 SGTC_2110 5483698 200 µM -0.558199963323347 0.271569795834617 no 2449 0.28835392295855 775 2848765 YHR062C RPP1 SGTC_499 genistein 192 µM -0.560986431663424 0.270564334257184 no 2450 0.287403393440917 793 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2231 micatex 6.853 µM -0.561350552879078 0.270433083268739 no 2451 0.287279292751579 788 20737 An antifungal of unknown mechanism. SGTC_1744 st037937 38.9 µM -0.562877269087586 0.26988311038201 no 2452 0.286759229826093 795 1016152 SGTC_574 1315-0397 40 µM -0.563013797438006 0.269833955712158 no 2453 0.286712744350173 791 6794277 SGTC_141 0443-0274 32.331 µM -0.564276438525028 0.269379576159618 no 2454 0.286283006909563 765 1627241 SGTC_531 3788-1495 174 µM -0.567002762519058 0.268399779489072 no 2455 0.28535615237203 757 2896655 SGTC_2218 6965428 192.983 µM -0.567454901755935 0.268237461394545 no 2456 0.285202579165999 772 675684 SGTC_654 1124-0271 80.9 µM -0.569043985429325 0.267667372080536 no 2457 0.284663145132659 790 5403748 SGTC_946 3434-1334 87.4 µM -0.57057875783629 0.267117347436327 no 2458 0.284142610574065 763 4047976 SGTC_2806 7952793 58.44 µM -0.571161291609819 0.266908731163838 no 2459 0.283945157229029 797 2972490 SGTC_2280 7785178 200 µM -0.571280305290881 0.26686612025964 no 2460 0.283904824901492 771 2954328 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.57159620286913 0.26675303496345 no 2461 0.283797784251748 791 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2816 7982706 58.44 µM -0.571780483599388 0.266687077170642 no 2462 0.283735350377304 801 2981853 SGTC_396 dithiazanine 1.25 µM -0.572715976215677 0.266352372686021 no 2463 0.283418509185271 776 10578 An antihelmenthic. SGTC_3181 9108277 49.47 µM -0.573630234278336 0.266025471096936 no 2464 0.283109023879096 805 17097298 SGTC_785 1270-0111 65.3 µM -0.574136296229279 0.265844611293292 no 2465 0.282937786709365 781 6741994 SGTC_3304 9125678 46.087 µM -0.574207201017542 0.265819275844092 no 2466 0.282913798490363 797 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1170 0310-0127 64.8 µM -0.575639900311586 0.265307611100799 no 2467 0.282429302852875 814 774975 SGTC_1963 st076565 50.3 µM -0.575647712068658 0.265304822632599 no 2468 0.282426662246742 805 4914280 SGTC_1350 1495-0454 146 µM -0.575902954088191 0.265213720169134 no 2469 0.282340389388909 779 1069057 SGTC_1721 st082152 9.2685 µM -0.57615395581357 0.265124146669646 no 2470 0.282255562134481 784 5296051 SGTC_3099 9120367 49.47 µM -0.57713883614913 0.264772826747868 no 2471 0.28192283556039 801 24824940 SGTC_1831 st055328 12 µM -0.578758502574244 0.264195585330094 no 2472 0.281376067572655 791 1103068 SGTC_441 propafenone 146 µM -0.578808429948762 0.26417780163994 no 2473 0.281359221193341 787 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2514 salinomycin 42.74 µM -0.579397451506232 0.263968043397609 no 2474 0.28116051165894 792 23682228 A polyether potassium ionophore. SGTC_1324 1418-0026 34.4 µM -0.579484073489946 0.263937203342866 no 2475 0.281131294992796 795 1372513 SGTC_3268 9137683 49.47 µM -0.581261187860801 0.263304902297556 no 2476 0.280532217253099 835 1953228 SGTC_1059 3448-6867 171 µM -0.581634956383041 0.263172013193861 no 2477 0.280406295939835 794 3934407 SGTC_1711 st032263 62.8 µM -0.582305791793373 0.26293359133564 no 2478 0.280180362483934 795 3958979 SGTC_2506 ethyl hematommate 54.16 µM -0.583431245836462 0.262533841489323 no 2479 0.279801514357141 788 3940691 An allergen. SGTC_1063 disulfiram 1.84 µM -0.58400950292314 0.262328571488533 no 2480 0.279606959283819 801 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_913 3487-1245 167 µM -0.584114817467183 0.262291195727472 no 2481 0.279571533188919 765 4016153 SGTC_14 0354-0009 295 µM -0.585064339752447 0.26195433681382 no 2482 0.279252227807027 804 1713507 SGTC_1311 1190-0148 100 µM -0.586753663385907 0.261355569860102 no 2483 0.278684580538009 810 1961333 SGTC_1602 st001878 87.6 µM -0.587080848677551 0.261239683021861 no 2484 0.278574704568173 825 595405 YLR310C CDC25 SGTC_108 0509-0257 621.132 µM -0.587262102946463 0.261175495340496 no 2485 0.278513844507526 782 536624 SGTC_1702 st027038 51 µM -0.587625642455459 0.261046779313827 no 2486 0.278391797742281 780 5521182 SGTC_626 0214-0009 33 µM -0.588170317156792 0.26085399100155 no 2487 0.278208989420939 800 3437874 SGTC_1504 k297-0033 30 µM -0.588610866165974 0.260698111704528 no 2488 0.278061171476031 757 4388117 SGTC_3092 9117248 49.47 µM -0.588973178322399 0.260569950857821 no 2489 0.277939633157574 803 17141857 SGTC_1084 voriconazole 435 nM -0.589034414674814 0.260548292899394 no 2490 0.277919093865515 815 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2449 5812982 45.77 µM -0.58903951385757 0.260546489471791 no 2491 0.277917383581449 800 776185 SGTC_1935 st074532 41.6 µM -0.589512251276813 0.260379324383409 no 2492 0.277758848084596 801 2829742 SGTC_672 1441-0018 53.7 µM -0.590620159650405 0.25998777251508 no 2493 0.277387477093629 769 251141 SGTC_2902 5787006 60.46 µM -0.592527293685684 0.259314473931705 no 2494 0.276748774756149 788 591003 SGTC_71 0417-1750 47.813 µM -0.59542543650986 0.258293035150878 no 2495 0.275779563420727 746 6811472 SGTC_929 2805-0021 398 µM -0.596259846855876 0.257999337655033 no 2496 0.275500825350569 827 3098024 SGTC_3285 9112818 20.8695 µM -0.597195526886893 0.257670201196647 no 2497 0.275188422654536 806 17017947 YPR165W RHO1 SGTC_231 b-estradiol 524 µM -0.59849689322142 0.257212792998312 no 2498 0.274754215647951 782 450 A steroid. SGTC_1671 st016596 74.5 µM -0.598811543651198 0.257102262113414 no 2499 0.274649281782026 803 2829167 SGTC_2056 5235370 200 µM -0.599842122115815 0.256740411952257 no 2500 0.274305729036926 788 5511916 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.602321985928127 0.255870785703729 no 2501 0.273479914341593 797 4174840 SGTC_1810 st050138 53 µM -0.602851892456887 0.25568516027394 no 2502 0.273303610905391 828 3444541 SGTC_2158 5657123 3.6195 µM -0.603303389054338 0.255527057219146 no 2503 0.273153439404879 824 2858827 SGTC_3154 9100113 49.47 µM -0.604291898532891 0.255181083799821 no 2504 0.272824795806828 809 25237525 SGTC_2645 abamectin 100 µM -0.604923981636775 0.254959986308328 no 2505 0.272614753923633 792 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2082 5219693 150 µM -0.606611529129866 0.254370187439744 no 2506 0.272054373617486 799 2834649 SGTC_209 4077-0173 175.592 µM -0.60682134511366 0.254296906642515 no 2507 0.271984740524587 778 15993494 SGTC_2164 5685496 200 µM -0.607004844341419 0.254232826367519 no 2508 0.27192384862387 799 759046 SGTC_402 epigallocatechin gallate 10 µM -0.607500839606202 0.254059660865503 no 2509 0.271759292805647 809 65064 An antioxidant. SGTC_2961 9083290 32.55 µM -0.607972841336443 0.253894929638601 no 2510 0.271602743333082 811 17741490 SGTC_1150 3909-7983 10.9 µM -0.609915135673486 0.253217648549118 no 2511 0.270959012821295 803 23965914 SGTC_3267 9137951 49.47 µM -0.609995973373557 0.253189480923798 no 2512 0.270932237462433 819 16643986 SGTC_1674 st016616 23.6 µM -0.61412059478873 0.251754460231569 no 2513 0.269567819973708 798 625830 SGTC_369 0957-0393 4.5 µM -0.615512867746965 0.251271037876704 no 2514 0.269108037027345 814 6997992 SGTC_131 0141-0277 33.849 µM -0.616127507762341 0.251057780020513 no 2515 0.268905184152712 821 1547771 SGTC_1420 4'-methoxyflavone 42 µM -0.617737004729654 0.250499796785357 no 2516 0.268374357421174 799 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2671 danthron 100 µM -0.618133388772311 0.250362478586679 no 2517 0.268243707282283 802 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1908 st060353 56.5 µM -0.618406962970133 0.25026772833268 no 2518 0.268153554543022 837 4227716 SGTC_2154 5570129 200 µM -0.61898533772345 0.250067475429823 no 2519 0.267963009042167 831 673366 SGTC_95 0471-0001 561.058 µM -0.619377069693709 0.249931892873424 no 2520 0.267833991724874 790 4015405 SGTC_2565 isoliquiritigenin 100 µM -0.621435960543614 0.249219930963273 no 2521 0.267156408808838 786 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_854 0422-0053 192 µM -0.621609344182805 0.249160024390497 no 2522 0.267099387617921 806 3596728 SGTC_614 0462-0418 107 µM -0.623265886837454 0.248588051141988 no 2523 0.26655490551368 785 5188303 SGTC_1579 chlormadinone acetate 49.4 µM -0.624111149478561 0.248296467474172 no 2524 0.266277296093699 813 45114258 A steroidal progestin. SGTC_1917 st066507 28.5 µM -0.624702861901452 0.248092457603951 no 2525 0.266083047228313 787 3156428 SGTC_579 4491-1009 110 µM -0.627140098538072 0.247253093735754 no 2526 0.265283702248482 833 1271041 SGTC_261 5-fluorouridine 15.376 µM -0.627270560727631 0.247208206504956 no 2527 0.265240948723265 788 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_178 4092-0806 87.505 µM -0.627497355927664 0.247130185009297 no 2528 0.265166634411265 803 2169044 SGTC_1754 st042065 16.137 µM -0.627830607483899 0.247015564573811 no 2529 0.265057456577419 809 1126236 YIL048W NEO1 SGTC_1163 k060-0048 49.9 µM -0.628078110133972 0.246930455515066 no 2530 0.264976386055554 803 6809982 SGTC_1130 3454-2858 15.9 µM -0.631182931843673 0.245864130938849 no 2531 0.263960460350805 838 715628 YIL048W NEO1 SGTC_2836 9010338 19.48 µM -0.631246512135507 0.245842320682473 no 2532 0.263939677067017 788 2994051 SGTC_136 0097-0015 404.482 µM -0.63125227825312 0.245840342754499 no 2533 0.263937792265416 806 4861337 SGTC_1142 3253-1408 9.78 µM -0.63190641044911 0.24561601389512 no 2534 0.263724017131271 815 256655 SGTC_3290 9121031 71.43 µM -0.632189901037633 0.245518827460787 no 2535 0.263631397793195 804 17014854 SGTC_2892 9047358 58.44 µM -0.632632958589375 0.245366979556721 no 2536 0.263486679502651 811 6466771 SGTC_312 4092-0653 6.84 µM -0.634188054751752 0.244834405429285 no 2537 0.262979051127477 816 1148278 SGTC_3318 9139014 38.6185 µM -0.637275290593455 0.243778965354868 no 2538 0.261972771501481 830 16643984 SGTC_121 0557-0495 61.343 µM -0.637414026465905 0.243731593149026 no 2539 0.261927597158762 834 3104427 SGTC_137 0438-0332 85.389 µM -0.639172283946426 0.243131656274671 no 2540 0.261355430194599 833 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_271 rotenone 740 µM -0.640671585680698 0.242620709386737 no 2541 0.26086803945648 829 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2659 sanguinarine 24.21 µM -0.641056798119028 0.242489526821467 no 2542 0.260742890713102 822 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1105 epirubicin 18.1 µM -0.641953347998289 0.242184359145077 no 2543 0.260451737103201 813 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_508 roscovitine 141 µM -0.642203360328799 0.242099297078455 no 2544 0.260370575733001 833 160355 A CDKinase inhibitor. SGTC_52 0329-0193 875 nM -0.642211686208478 0.242096464630794 no 2545 0.260367873131272 836 3739292 SGTC_2246 7293507 91.5585 µM -0.642554993145825 0.241979687942672 no 2546 0.260256447409724 812 887656 SGTC_1936 st074407 74.3 µM -0.643279981111156 0.241733181944425 no 2547 0.260021221807876 823 809813 SGTC_2210 7115885 190.385 µM -0.644526926412047 0.241309522190841 no 2548 0.259616901388797 827 2927039 SGTC_360 0957-0399 1.01 µM -0.646769100705709 0.240548741399491 no 2549 0.258890696633749 817 6752301 YPR165W RHO1 SGTC_1461 k072-0203 53.8 µM -0.646819856749842 0.240531534752697 no 2550 0.258874269727344 815 5418714 SGTC_1470 k295-0292 231 µM -0.647010405118783 0.240466943530993 no 2551 0.258812604639093 825 5045612 SGTC_1027 k015-0025 8.67 µM -0.647646713314227 0.24025131912187 no 2552 0.258606738251343 813 3598955 SGTC_750 4073-0104 132 µM -0.648936411108048 0.239814605334909 no 2553 0.258189739322382 798 22330957 SGTC_619 1652-1634 108 µM -0.650938089681484 0.239137661196874 no 2554 0.257543226164882 824 5400454 SGTC_2937 9044753 11.33 µM -0.652190501689711 0.238714641903845 no 2555 0.257139143290691 805 6465530 YGL099W LSG1 SGTC_1173 0443-0020 122 µM -0.653068911408263 0.238418191456413 no 2556 0.256855926735977 813 5331295 SGTC_897 1000-0139 31.4 µM -0.653157864324564 0.23838818239135 no 2557 0.256827255622487 817 6151020 SGTC_68 0986-0284 82.829 µM -0.653838140361918 0.238158753571546 no 2558 0.256608045597315 800 423278 YIL048W NEO1 SGTC_69 0096-0274 206.684 µM -0.654179181105921 0.238043780257603 no 2559 0.256498186374465 836 6741392 SGTC_3097 9117246 49.47 µM -0.654770842869506 0.237844388559358 no 2560 0.256307652916004 810 16423892 SGTC_1213 1315-0166 115 µM -0.655282667245126 0.237671976200974 no 2561 0.256142889107384 799 768401 SGTC_1243 0416-0003 5.65 µM -0.655934143659386 0.237452620098592 no 2562 0.255933249173247 821 2141977 SGTC_1440 4100-1550 40 µM -0.656462018949709 0.237274962794145 no 2563 0.255763448784644 823 742806 SGTC_916 4466-0038 42 nM -0.656998020972772 0.237094645146349 no 2564 0.255591094485681 830 5722064 YGL116W CDC20 SGTC_3079 9117512 49.47 µM -0.65837650190404 0.236631253295008 no 2565 0.255148115402627 867 7185044 SGTC_1705 st027868 56.3335 µM -0.659292958004583 0.236323452236402 no 2566 0.254853831777565 822 292948 SGTC_3110 9122132 49.47 µM -0.659381323475588 0.236293785455323 no 2567 0.254825466095744 800 918317 SGTC_1938 st074717 56.4 µM -0.659948655167263 0.236103365060131 no 2568 0.254643389648812 793 17250979 SGTC_2996 9066192 71.4286 µM -0.660818601676232 0.23581153867051 no 2569 0.254364325994771 813 6472854 SGTC_677 0929-0063 136 µM -0.661831537101036 0.235471996911741 no 2570 0.254039596089934 843 1539583 SGTC_1978 st071761 42 µM -0.661987912204204 0.235419603130861 no 2571 0.253989484272712 810 5147680 SGTC_1762 st045503 25.4615 µM -0.662034739058022 0.235403914954769 no 2572 0.253974479192764 818 4645554 SGTC_173 1273-0061 2.693 µM -0.662965937871792 0.235092059739544 no 2573 0.253676184798104 818 2847414 YPL266W DIM1 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.663753229777333 0.23482857656915 no 2574 0.253424132254421 822 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2728 chlorpromazine 9.18 µM -0.663867984160601 0.234790185326592 no 2575 0.253387404480474 865 2726 A thorazine and dopamine antagonist. SGTC_2593 nobiletin 86.24 µM -0.664056824244452 0.234727016160579 no 2576 0.253326971259578 811 72344 An anti-infammatory. SGTC_3120 9124077 49.47 µM -0.664652431812646 0.234527840192478 no 2577 0.253136412626915 838 18774327 YGL155W CDC43 SGTC_519 k048-0011 62.8 µM -0.665190949797794 0.234347835949281 no 2578 0.252964184153831 811 6836379 SGTC_1369 1866-0067 208 µM -0.666465268578122 0.233922188691664 no 2579 0.252556878083447 817 3531355 SGTC_2070 5230947 200 µM -0.666482561772891 0.233916415375573 no 2580 0.252551353097051 840 2835538 SGTC_2560 caryophyllene 100 µM -0.666923562223087 0.233769214487943 no 2581 0.252410479801657 819 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2302 7771753 200 µM -0.669749910943589 0.232827031713383 no 2582 0.251508614443371 816 2203047 SGTC_700 3453-2283 142 µM -0.670243649921922 0.232662657182362 no 2583 0.251351241155674 828 565664 SGTC_2676 harmalol 100 µM -0.670535506504579 0.232565523251676 no 2584 0.251258239909026 817 5459187 A monoamine oxidase inhibitor SGTC_2699 st077704 54.6 µM -0.670953423560355 0.232426473907501 no 2585 0.251125100685282 820 645852 SGTC_3006 9075424 71.4286 µM -0.672424996415463 0.231937220506729 no 2586 0.250656587007031 820 7465181 SGTC_3148 9097893 49.47 µM -0.672717805290459 0.231839938881674 no 2587 0.250563418904776 795 17174100 SGTC_2430 5571206 200 µM -0.673602390922372 0.231546185854342 no 2588 0.250282066353742 834 1731771 SGTC_970 1315-0089 19.5 µM -0.673835029110359 0.23146896588131 no 2589 0.250208100953405 815 6811083 YLR033W RSC58 SGTC_86 0417-1630 471.922 µM -0.67400802868572 0.231411551160328 no 2590 0.250153104676379 824 3634867 SGTC_1444 4112-3581 28 µM -0.674330819934205 0.231304445141834 no 2591 0.25005050702075 826 2877249 SGTC_1591 genipin 88.4 µM -0.674436011982775 0.231269547129625 no 2592 0.250017077054723 847 442424 A DNA cross-linking agent. SGTC_2464 5717415 7.67 µM -0.67488197355113 0.231121629672914 no 2593 0.249875377094962 811 5285744 SGTC_340 k038-0059 454 µM -0.674974430057102 0.231090970116127 no 2594 0.249846005273648 828 23733424 SGTC_3198 9112019 49.47 µM -0.676039927210445 0.230737803826294 no 2595 0.249507647699911 863 45595555 SGTC_2120 5538279 151.968 µM -0.677518644615224 0.230248172798993 no 2596 0.249038472298318 813 2058197 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.677797141571922 0.230156022312272 no 2597 0.248950161844813 837 6708784 An antioxidant flavonoid SGTC_2081 5214970 32.255 µM -0.678075620280829 0.230063898496945 no 2598 0.248861873844283 822 2063512 SGTC_202 3594-0513 34.79 µM -0.678493007271695 0.229925860942237 no 2599 0.248729578023086 826 708429 SGTC_755 1995-0008 37.3 µM -0.679138167327596 0.229712585885361 no 2600 0.248525160498504 802 689533 SGTC_1603 st002045 67.8 µM -0.679603669158731 0.229558770536799 no 2601 0.248377722893397 833 5887985 SGTC_869 0564-0080 44.1 µM -0.680579842706918 0.229236401856542 no 2602 0.248068692561493 815 6843321 SGTC_1723 st034307 2.5525 µM -0.680981339093322 0.229103886580357 no 2603 0.247941649145046 840 867466 SGTC_2817 7995342 71.43 µM -0.681620786288343 0.228892923553672 no 2604 0.247739383899263 836 18879975 SGTC_1975 st070967 30.8 µM -0.682334023797691 0.228657744690321 no 2605 0.24751388182834 832 261391 SGTC_9 0092-0002 10.449 µM -0.683753689512286 0.228190036312146 no 2606 0.247065357161926 836 759368 SGTC_1034 k072-0165 12.7 µM -0.684779918642426 0.22785228067664 no 2607 0.246741404552335 842 5835461 SGTC_2137 5261020 140 µM -0.686365631709347 0.227330939580061 no 2608 0.246241285654475 824 763655 SGTC_1662 st014054 52 µM -0.686981910943174 0.227128504548157 no 2609 0.246047063780312 830 2838777 SGTC_2528 xanthyletin 44.79 µM -0.688418038087251 0.226657160908445 no 2610 0.24559478395078 850 65188 An natural product with antifungal activity of unknown mechanism. SGTC_51 1013-0126 23.419 µM -0.688709717253929 0.22656149793493 no 2611 0.245502979956067 824 1627850 SGTC_2452 5863136 48.41 µM -0.688764701186454 0.226543467227775 no 2612 0.245485676210208 827 2184096 SGTC_2726 cimetidine 79.27 µM -0.689092276448511 0.226436063299186 no 2613 0.245382600056691 841 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1625 st003711 30.1 µM -0.689800197133365 0.22620405164015 no 2614 0.245159922351132 841 24207034 YER133W GLC7 SGTC_2409 alverine citrate 63.97 µM -0.690375572082794 0.22601557908881 no 2615 0.244979017224865 809 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_777 1315-0167 517 µM -0.691235253217632 0.225734143325982 no 2616 0.244708856532554 827 4221767 SGTC_488 nitrendipine 139 µM -0.691479464412608 0.225654231524666 no 2617 0.244632140756623 830 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2470 5664817 21.68 µM -0.692473212966579 0.225329218134108 no 2618 0.244320101179493 836 2859561 SGTC_2972 9093619 59.92 µM -0.69422284579147 0.224757631476372 no 2619 0.243771233777345 808 25236256 SGTC_464 bw-b 70c 158 µM -0.695976784448236 0.224185464303066 no 2620 0.243221684348038 852 5353454 SGTC_174 3553-0389 74.3 µM -0.696672696291596 0.223958674416169 no 2621 0.243003824844716 823 738071 SGTC_538 2922-0838 53.3 µM -0.697197752377362 0.223787650824119 no 2622 0.242839522680985 830 777039 SGTC_1269 0831-0796 3.05 µM -0.698402912263314 0.223395381698746 no 2623 0.242462627804476 828 927758 SGTC_2519 cryptotanshinone 88.04 µM -0.699810699481414 0.222937654952804 no 2624 0.242022765970742 821 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3022 9087993 49.47 µM -0.701023274539972 0.222543827934106 no 2625 0.241644245186841 837 17173644 SGTC_1318 1280-3875 124 µM -0.70134986616208 0.222437823499269 no 2626 0.241542350409139 856 373245 SGTC_2117 5521686 200 µM -0.703603813608699 0.221707027535477 no 2627 0.240839767873327 834 803312 SGTC_1381 2324-0066 62.1 µM -0.705303055722109 0.221156991449327 no 2628 0.240310829620674 841 10885928 SGTC_2963 9082507 9 µM -0.711307644055445 0.219219602186999 no 2629 0.238446807873647 841 16459611 SGTC_284 0988-0104 32.6 µM -0.712313707229106 0.21889595135349 no 2630 0.238135268923011 847 4666532 SGTC_2180 6301957 200 µM -0.713036022904136 0.218663751804549 no 2631 0.237911733254758 841 845462 SGTC_345 1362-0200 395 µM -0.716601515163624 0.217519648414245 no 2632 0.236810004659051 841 1419823 SGTC_2217 6934799 96.0675 µM -0.716903227368414 0.217422993126955 no 2633 0.236716905227094 838 675606 SGTC_3091 9116372 49.47 µM -0.717006965166553 0.217389765839845 no 2634 0.236684899472892 859 17169793 SGTC_1046 2001-0062 216 µM -0.717084062928155 0.217365073273829 no 2635 0.236661114390835 848 739778 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.718572637935632 0.216888635956896 no 2636 0.236202138711617 847 803109 SGTC_1967 st070177 51.4 µM -0.721455244724972 0.215967739525011 no 2637 0.235314733633731 854 5729214 SGTC_1718 roemerine 11.9335 µM -0.722123501312383 0.215754577807379 no 2638 0.235109275204823 822 235224 An aporphine alkaloid with mutagenic activity. SGTC_642 0335-0876 158 µM -0.723015810590055 0.215470137580149 no 2639 0.234835085342825 844 6812350 SGTC_1375 2910-0797 186 µM -0.723308898030718 0.215376757968395 no 2640 0.234745063659555 851 742508 SGTC_37 0566-0070 1.56 µM -0.72411663856327 0.215119528005101 no 2641 0.234497065270048 851 1626686 SGTC_1818 st052136 56.3 µM -0.727292688274131 0.21410982628854 no 2642 0.233523338137633 839 674169 SGTC_2291 7917025 104.35 µM -0.727660234479103 0.213993157551762 no 2643 0.233410799174372 840 2964612 SGTC_343 4130-2827 29.8 µM -0.727720605439522 0.213973997775785 no 2644 0.233392317068854 833 1118244 SGTC_681 1642-0006 26.6 µM -0.728913417309082 0.213595642981505 no 2645 0.233027313431518 869 4446530 SGTC_2558 carylophyllene oxide 100 µM -0.729757910805665 0.213328009117052 no 2646 0.232769087931886 865 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3082 9117008 49.47 µM -0.7300060896607 0.213249394346903 no 2647 0.232693231137806 847 41448529 SGTC_2904 7225135 42.03 µM -0.730072521555004 0.21322835380874 no 2648 0.232672928312584 883 4446116 SGTC_2776 terbinafine 19.92 µM -0.730541771479773 0.213079765839297 no 2649 0.232529544833411 830 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_726 3448-4391 34.2 µM -0.730707154995497 0.213027411555103 no 2650 0.232479022144151 851 1356692 SGTC_1804 st050076 49.1 µM -0.731428302089906 0.212799210873307 no 2651 0.232258791677049 851 3895976 SGTC_463 ikarugamyin 104 µM -0.731612753086622 0.212740865896391 no 2652 0.232202481000566 868 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1193 1488-0126 41.5 µM -0.734454565784791 0.211843133432679 no 2653 0.23133587057494 838 1384710 SGTC_536 3852-0578 10.6 µM -0.73495394800709 0.211685607191176 no 2654 0.231183770594821 857 2869208 SGTC_168 3970-0862 530.542 µM -0.735872576988549 0.211396011938118 no 2655 0.230904123778046 849 3135186 SGTC_2227 7312221 64.1025 µM -0.737112437237762 0.211005517573317 no 2656 0.230526988186912 871 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3337 9144342 33.5465 µM -0.737449403669694 0.210899463016329 no 2657 0.230424550651347 834 17682949 SGTC_850 0388-0143 75.9 µM -0.73800914440358 0.210723363067727 no 2658 0.230254446156927 853 67273 SGTC_2587 piperic acid 92.2 µM -0.740574720454407 0.209917312045677 no 2659 0.22947567022002 835 5370536 SGTC_1957 st077035 62.4 µM -0.740724260237975 0.209870385689478 no 2660 0.229430323261801 868 705593 SGTC_528 3492-0019 172 µM -0.741723588719646 0.209556949571939 no 2661 0.229127412414156 852 2869262 SGTC_1780 st038448 24.544 µM -0.743776518543028 0.208913919339668 no 2662 0.228505844113773 857 728868 YDL195W SEC31 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.745240129953146 0.208456189327087 no 2663 0.228063283545021 867 23847180 SGTC_3053 9095903 49.47 µM -0.745975428191157 0.208226455439272 no 2664 0.227841129250772 893 17174018 SGTC_1494 4358-1428 177 µM -0.746188404225378 0.208159941898994 no 2665 0.227776805946425 848 1564571 SGTC_1136 pergolide 1.05886 µM -0.747042050252398 0.207893469608004 no 2666 0.227519089245242 853 47811 A dopamine receptor agonist. SGTC_3115 9123671 49.47 µM -0.747165390081327 0.207854984776019 no 2667 0.227481866393578 864 3286988 SGTC_2134 5324836 1.464 µM -0.748229568501241 0.207523111689956 no 2668 0.227160849410199 868 699272 SGTC_1512 0259-0544 12.2 µM -0.749889314519105 0.207006131351503 no 2669 0.226660685301826 844 18476 SGTC_1609 st001574 46.4 µM -0.751197317237975 0.206599250019898 no 2670 0.226266957263926 866 3960012 SGTC_2619 obliquin 87.91 µM -0.752160389891544 0.206299969325098 no 2671 0.225977305393655 848 6708593 A bioactive alkalod. YER133W GLC7 SGTC_701 4424-0219 185 µM -0.752644790863923 0.206149535943112 no 2672 0.225831697164569 847 2911779 SGTC_1659 st012954 42.1 µM -0.752841902320142 0.206088340519396 no 2673 0.225772461753114 855 24207262 SGTC_3015 9080845 49.47 µM -0.754788327841936 0.205484629843837 no 2674 0.225187999213948 850 5296973 SGTC_2804 7954240 19.48 µM -0.756141520224063 0.205065538084008 no 2675 0.224782175194627 845 828705 SGTC_1959 st077091 55.8 µM -0.756191675265985 0.205050014538164 no 2676 0.224767141611838 863 821356 YKL052C ASK1 SGTC_1801 st050089 28.441 µM -0.758500460464027 0.204336176116111 no 2677 0.224075718734254 853 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_482 fipronil 114 µM -0.75909683393 0.204152027967609 no 2678 0.22389731647954 849 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_181 1447-1644 8.07 µM -0.760613547286298 0.203684142914751 no 2679 0.223443962841834 878 534600 SGTC_628 1636-0253 16 µM -0.760710619107554 0.203654219388472 no 2680 0.223414965354167 859 4456143 SGTC_2104 5389443 200 µM -0.762530749376434 0.203093628421366 no 2681 0.222871649013763 859 2244536 SGTC_2478 5763493 32.33 µM -0.76287882662691 0.202986527416171 no 2682 0.222767832338366 848 1365576 YLR208W SEC13 SGTC_2725 haloperidol 53.21 µM -0.76325251486789 0.202871583634178 no 2683 0.222656407671958 851 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3011 9081274 71.4286 µM -0.763315178366822 0.202852312605443 no 2684 0.222637726064613 871 6625322 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.764126205086593 0.202602994647165 no 2685 0.222396018687708 878 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2202 7226349 200 µM -0.764256690635743 0.202562899158047 no 2686 0.222357144531378 847 844334 SGTC_2366 9070441 60.58 µM -0.764759590054114 0.20240841302412 no 2687 0.222207357379228 859 6837235 SGTC_839 0122-0028 230 µM -0.766355566281085 0.201918610409929 no 2688 0.221732381936756 865 759448 SGTC_2290 7904846 200 µM -0.766714395131022 0.201808584173164 no 2689 0.22162567149014 855 2962154 SGTC_573 3702-0553 84.7 µM -0.766817328123947 0.20177702887382 no 2690 0.221595066142727 856 1222756 SGTC_1300 1094-0077 113 µM -0.767656515483254 0.201519876540919 no 2691 0.221345638415745 858 5532636 SGTC_1033 k072-0102 21.3 µM -0.7680155284295 0.201409924139802 no 2692 0.221238979735024 855 5965931 SGTC_1841 st054148 70 µM -0.768419423915928 0.201286268862802 no 2693 0.221119022108731 874 675442 SGTC_1347 1493-0251 600 nM -0.769524169432295 0.200948276281991 no 2694 0.220791101045195 832 3986378 SGTC_3070 9117005 49.47 µM -0.769747388001067 0.200880024805403 no 2695 0.220724877022978 865 8779016 SGTC_2321 7390090 138.78 µM -0.770866133894008 0.200538165836517 no 2696 0.220393141248822 869 649046 SGTC_931 2812-0076 566 µM -0.771783044267861 0.200258243106353 no 2697 0.220121467913684 865 3450959 SGTC_292 k038-0015 474 µM -0.772159405601161 0.200143412097097 no 2698 0.220010010636512 869 46368540 SGTC_2030 5175110 200 µM -0.772943600948293 0.199904274675739 no 2699 0.21977787967529 874 2831986 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.773402283921332 0.199764480708009 no 2700 0.219642169364704 881 65057 A dermal irritant. YDR527W RBA50 SGTC_2323 6148992 148.28 µM -0.773848473366555 0.199628550866547 no 2701 0.219510201693544 867 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1820 st053765 18.6 µM -0.779052514060403 0.198047274250772 no 2702 0.217974390487525 855 3690829 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.779797616429718 0.197821491399059 no 2703 0.217755004789499 897 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3035 9091303 49.47 µM -0.780960075421893 0.197469550798441 no 2704 0.217412988373985 868 25237002 SGTC_117 lucigenin 22.078 µM -0.781927003735449 0.197177096768433 no 2705 0.217128737044801 880 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_589 1227-0070 34.1 µM -0.783471152794875 0.196710602184315 no 2706 0.216675243619506 849 2841384 SGTC_737 1950-0117 57.9 µM -0.784335893835726 0.196449652153896 no 2707 0.216421521620576 871 5393513 SGTC_2451 5856223 45.7 µM -0.784376593965178 0.196437375382633 no 2708 0.216409584112514 864 2179896 SGTC_1685 st024049 53.0905 µM -0.784461028774272 0.196411907982473 no 2709 0.216384820266253 866 1941139 SGTC_391 gliotoxin 8.33 µM -0.784713653878326 0.196335722632215 no 2710 0.216310737761198 888 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2362 9071156 126 µM -0.785486569142899 0.196102742180467 no 2711 0.216084170969314 886 653133 SGTC_1597 7-benzyloxygramine 47.5 µM -0.785997940233023 0.195948691400218 no 2712 0.215934346927997 859 260807 SGTC_503 tyrphostin 8 294 µM -0.786231286489031 0.195878420133741 no 2713 0.215865999987424 906 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3175 9106517 49.47 µM -0.786536591818712 0.195786501783642 no 2714 0.215776595223168 878 41468073 SGTC_1490 4089-0339 670 nM -0.787257841556655 0.195569458946051 no 2715 0.215565471717276 854 742542 SGTC_3317 9138495 8.753 µM -0.78770478660671 0.195435034884771 no 2716 0.215434702546979 863 17020139 SGTC_10 0279-0212 42.575 µM -0.787712930283824 0.195432586097339 no 2717 0.215432320260681 851 39851 YBR002C RER2 SGTC_460 trequinsin 123 µM -0.788167474848495 0.195295935007503 no 2718 0.215299375654975 891 5537 A vasodilator. SGTC_3276 9139060 49.47 µM -0.788609810305241 0.195163010129653 no 2719 0.215170047671661 895 4870619 SGTC_2300 7976697 71.57 µM -0.78995305473887 0.194759692986476 no 2720 0.214777592611512 854 2236109 SGTC_1247 0448-0043 5.84 µM -0.790116096575066 0.194710773232358 no 2721 0.214729985079576 895 3089013 YGL099W LSG1 SGTC_1863 st057641 20.1 µM -0.790747209677483 0.194521481901875 no 2722 0.214545760519064 885 3921635 SGTC_1025 k007-0731 70 µM -0.791661726403727 0.194247387429648 no 2723 0.214278972353435 864 6256118 SGTC_55 0767-0285 6.563 µM -0.791671772596609 0.194244377740609 no 2724 0.214276042691339 876 3116166 SGTC_1886 st057356 49.9 µM -0.791804422313082 0.194204640533878 no 2725 0.214237361680554 861 24207747 SGTC_1003 4049-0218 100 µM -0.792126393180676 0.194108209939574 no 2726 0.214143491015629 869 295161 SGTC_1314 1222-0010 41.1 µM -0.792249626166291 0.194071309257997 no 2727 0.214107568750535 882 3526027 SGTC_1739 st037196 92.5 µM -0.792996129457508 0.193847868915246 no 2728 0.213890038924835 867 612214 SGTC_2163 5671233 125 µM -0.79394490644702 0.193564111225049 no 2729 0.213613752666193 857 701023 SGTC_123 0083-0120 66.675 µM -0.794695071957035 0.193339933163801 no 2730 0.213395449842646 888 16001701 SGTC_954 1189-0853 2.85 µM -0.794952928883417 0.193262912284058 no 2731 0.213320441919332 863 2828194 SGTC_572 0960-0087 17.7 µM -0.79498823094385 0.193252369150878 no 2732 0.213310174110071 882 6796365 SGTC_731 3966-0296 387 µM -0.796269132530469 0.192870059100221 no 2733 0.212937811396536 849 660956 SGTC_2833 9001315 45.46 µM -0.796391847895984 0.192833456573026 no 2734 0.212902157518779 864 2989378 SGTC_2512 diallyl trisulfide 49.23 µM -0.796559379546387 0.1927834934655 no 2735 0.212853488286204 906 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_418 lividomycin a 100 µM -0.797633065808015 0.192463474898457 no 2736 0.212541728378126 869 72394 An antibiotic. SGTC_3192 9110362 49.47 µM -0.79773606037657 0.192432793836748 no 2737 0.212511836482634 890 16649480 SGTC_2431 5490079 200 µM -0.79805506426877 0.192337784713869 no 2738 0.212419268242377 887 5722345 SGTC_2051 5263410 176 µM -0.799741095326883 0.191836109701208 no 2739 0.211930408847266 865 227584 SGTC_500 h-89 112 µM -0.800289054547489 0.191673238223578 no 2740 0.211771671604906 881 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1168 k815-0004 80.5 µM -0.802040155086591 0.191153321633161 no 2741 0.21126486534116 875 642433 SGTC_195 4234-0266 16.654 µM -0.802378485821995 0.191052968134237 no 2742 0.211167027102169 871 2303354 SGTC_1464 k208-0027 110 µM -0.804151398230055 0.190527626631738 no 2743 0.210654771850921 860 X1464 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.804452230330461 0.1904385734992 no 2744 0.210567923538252 848 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1672 st016598 6.51 µM -0.805084436845494 0.190251509334183 no 2745 0.210385478032353 889 4665860 YNL267W PIK1 SGTC_3248 9135562 49.47 µM -0.807392724747232 0.189569466932461 no 2746 0.209720128559868 879 17650701 SGTC_1288 0973-0013 65.5 µM -0.807645384784419 0.189494903545309 no 2747 0.209647376093129 871 4315430 SGTC_1092 toremifene 6.32 µM -0.810329031862006 0.188704037335603 no 2748 0.208875546948932 879 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2499 avocadenofuran 51.48 µM -0.813142929229012 0.187876975190241 no 2749 0.208068057920487 892 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_836 0330-0104 1.35 µM -0.813294653305285 0.187832444064029 no 2750 0.208024570894137 848 46494820 SGTC_342 k048-0088 23.3 µM -0.813406320622066 0.187799673790171 no 2751 0.207992568330145 877 6820570 SGTC_3274 9138298 49.47 µM -0.8149111444588 0.187358407498498 no 2752 0.20756158675831 894 17015756 SGTC_866 0495-0101 262 µM -0.814934356653754 0.187351605905243 no 2753 0.207554942920983 855 635694 SGTC_930 2810-3379 265 µM -0.815605264533365 0.187155083722301 no 2754 0.207362968744056 894 1015764 SGTC_1284 0929-0043 16 µM -0.816375861310513 0.18692951806697 no 2755 0.207142599084043 883 1239883 SGTC_622 1348-1566 26.3 µM -0.817666646642279 0.186552062196339 no 2756 0.206773780206996 876 7340407 SGTC_872 0588-0139 234 µM -0.818136750441648 0.18641471016454 no 2757 0.206639553073708 859 2047100 SGTC_817 1391-0715 46 µM -0.819329193507216 0.186066590564361 no 2758 0.206299310408093 885 1353946 SGTC_2945 9067681 61.76 µM -0.82017751466222 0.185819178767371 no 2759 0.206057459135586 903 16456930 SGTC_2912 7964298 10.93 µM -0.820460766111592 0.185736614298641 no 2760 0.205976743303823 870 2975850 SGTC_2703 st077852 53.4 µM -0.820662416511449 0.18567784944681 no 2761 0.205919292079917 884 6281836 SGTC_447 ml7 120 µM -0.821075480011859 0.185557510722092 no 2762 0.205801637871577 889 4216 Selective myosin light chain kinase inhibitor. SGTC_1436 4092-1007 8.32 µM -0.821213521017735 0.185517305715839 no 2763 0.20576232810088 848 2881121 SGTC_812 4251-0442 148 µM -0.82137432143373 0.185470478756141 no 2764 0.205716542778958 903 5723007 SGTC_218 alverine citrate 93.75 µM -0.822108869100355 0.185256663209636 no 2765 0.205507469099109 870 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1429 4049-0205 9.46 µM -0.822564840791331 0.185124013882573 no 2766 0.205377749753227 858 22774478 SGTC_186 3455-3465 67.277 µM -0.823571936512625 0.184831243040575 no 2767 0.205091413562916 865 755278 SGTC_3288 9119690 36.221 µM -0.824053168845901 0.184691446591545 no 2768 0.204954674005258 901 17595618 YKL019W RAM2 SGTC_2040 5100729 123 µM -0.824180829936661 0.184654372489599 no 2769 0.204918408896917 875 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1147 3809-1045 12.3 µM -0.825901374881412 0.184155159957851 no 2770 0.204430020314202 861 325925 SGTC_979 1426-2828 121 µM -0.826262949300392 0.184050356809836 no 2771 0.204327473083698 887 747872 SGTC_2792 7535235 81.82 µM -0.826689873846475 0.183926659598878 no 2772 0.204206431140263 878 1281891 SGTC_2013 4024628 200 µM -0.827155903883602 0.183791691071131 no 2773 0.204074350741161 899 5230760 SGTC_1994 st072947 40.9 µM -0.830100733788007 0.182940256275078 no 2774 0.20324091613252 897 5286565 YDL195W SEC31 SGTC_1883 5-benzylidenerhodanine 20 µM -0.830635725052089 0.182785839575554 no 2775 0.203089723281227 854 1273210 SGTC_1881 5652484 16 µM -0.832661979512146 0.182201731501637 no 2776 0.202517696516664 887 2255129 SGTC_201 4262-0159 12.803 µM -0.832966805027121 0.182113960558755 no 2777 0.202431725425501 883 1341029 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.833779498708785 0.181880084115919 no 2778 0.202202625029837 861 688667 SGTC_1719 st032227 49.2 µM -0.835145462219748 0.181487411486527 no 2779 0.201817906123205 881 3125804 SGTC_1778 st046819 58.9 µM -0.835665408441074 0.181338082435625 no 2780 0.201671580310627 893 671715 SGTC_2364 9055074 200 µM -0.836419718875191 0.181121580571416 no 2781 0.201459411576212 893 6470630 SGTC_3122 9126309 49.47 µM -0.836965362947275 0.180965071012794 no 2782 0.201306018900783 906 17591206 SGTC_1574 spiramycin 23.7 µM -0.83789435140331 0.180698800092939 no 2783 0.201045020733415 883 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2618 avocadyne 43.43 µM -0.839492927375284 0.180241184325744 no 2784 0.200596378205392 880 3015189 SGTC_2068 5226020 147 µM -0.839576699396853 0.180217223431708 no 2785 0.200572884061465 903 1810509 SGTC_2943 9068529 45.32 µM -0.841382775939688 0.179701126607577 no 2786 0.20006676575572 895 3270634 SGTC_3298 9116858 71.43 µM -0.841803035060599 0.17958116844424 no 2787 0.199949106400318 934 2506942 SGTC_140 0062-0056 502.533 µM -0.841853092742754 0.179566883405889 no 2788 0.199935094595078 896 3758964 SGTC_1482 3346-2049 8.48 µM -0.841891657806865 0.179555878520821 no 2789 0.199924300127836 870 3826804 SGTC_2087 5276107 200 µM -0.842197034375349 0.179468751561113 no 2790 0.199838836763989 877 144405 SGTC_349 k015-0014 24 µM -0.843567723814268 0.179078007724555 no 2791 0.199455503319001 894 2196908 SGTC_3062 9077494 49.47 µM -0.844337729331524 0.178858736436001 no 2792 0.199240354270361 809 16459633 SGTC_1196 1588-0294 184 µM -0.844993431594238 0.178672148095859 no 2793 0.199057253198001 897 6144269 SGTC_1144 3486-0183 12.5 µM -0.845001116473491 0.178669961993553 no 2794 0.19905510784108 916 6744069 SGTC_695 3505-6186 243 µM -0.845308333713373 0.178582582311785 no 2795 0.198969354647343 877 1819379 SGTC_680 0417-1641 114 µM -0.845533183290812 0.178518646956229 no 2796 0.198906606756169 885 2835990 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.846161522082386 0.178340057009568 no 2797 0.198731321954687 888 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3236 9132701 49.47 µM -0.847484266324849 0.177964467371846 no 2798 0.198362626577076 901 24282524 SGTC_1870 st057514 26.5 µM -0.84819591793371 0.177762602353625 no 2799 0.19816443511806 887 5393161 SGTC_1690 st023502 41.2 µM -0.850666888441201 0.177062816178947 no 2800 0.197477210762309 873 24207482 SGTC_2539 epi(13)torulosol 80 µM -0.850913983985057 0.176992933837967 no 2801 0.197408568091694 869 6708597 SGTC_2016 5121758 140 µM -0.851188778160467 0.176915238377174 no 2802 0.19733224774241 879 2795203 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.851693856637506 0.176772488429591 no 2803 0.197192015612171 882 2346 DNA damaging agent; causes G2/M arrest. SGTC_1204 4049-0315 18.3 µM -0.853327761933069 0.176311197959905 no 2804 0.196738784393608 905 588402 SGTC_368 fentichlor 4.58 µM -0.853374015084203 0.176298150687087 no 2805 0.196725963358479 914 7329 A pesticide. SGTC_2433 5607874 27.82 µM -0.856634243002226 0.175380032196569 no 2806 0.19582352742238 881 2252428 SGTC_703 3875-0075 71.8 µM -0.858773034268782 0.17477937308324 no 2807 0.195232873792895 919 2850814 SGTC_2293 7624732 200 µM -0.861445646337003 0.174030633244838 no 2808 0.194496322463919 879 894453 SGTC_1751 st044839 27.194 µM -0.861673991031378 0.173966756524727 no 2809 0.194433470944479 865 5291326 SGTC_627 1391-0720 175 µM -0.86274863667741 0.173666337353365 no 2810 0.194137842463487 918 997839 SGTC_1165 k072-0275 30.3 µM -0.863405318431469 0.173482923327154 no 2811 0.193957328156784 895 6153523 YGL055W OLE1 SGTC_1016 4226-1401 38 µM -0.863804364214456 0.173371528375723 no 2812 0.19384768501146 883 2901613 SGTC_171 k064-0041 9.68 µM -0.864229402041339 0.173252927751581 no 2813 0.193730941765186 875 53325 SGTC_545 4218-0007 221 µM -0.865407543339516 0.17292445469739 no 2814 0.193407571091626 904 2840508 SGTC_2084 5306078 60.6385 µM -0.866040680446198 0.172748096205226 no 2815 0.193233926724499 918 679340 SGTC_698 k064-0052 127 µM -0.866801625561417 0.17253628892038 no 2816 0.193025355646059 933 5088751 SGTC_2240 6690706 185.951 µM -0.866960524491159 0.172492080687152 no 2817 0.19298181963633 886 805876 SGTC_2349 9023730 187.07 µM -0.867765654389889 0.172268191673189 no 2818 0.192761317865699 904 4126287 SGTC_1839 st053978 48 µM -0.868384584027801 0.172096206991472 no 2819 0.192591915651627 906 3788398 SGTC_2181 6316240 54.2555 µM -0.870314263719464 0.171560702246314 no 2820 0.192064343031816 908 12779990 SGTC_19 0279-0214 38.434 µM -0.87130876493295 0.171285134773137 no 2821 0.191792792992685 902 3566274 YBR002C RER2 SGTC_2914 7968218 45.32 µM -0.873466990343211 0.170688083676369 no 2822 0.191204295474456 866 2977111 SGTC_707 0865-0008 204 µM -0.873768958984628 0.170604653485107 no 2823 0.191122044070515 912 723043 SGTC_2600 tangeritin 87.95 µM -0.874458465492576 0.170414249272319 no 2824 0.190934314925312 904 68077 A bioactive flavone. SGTC_1889 st059080 5.18 µM -0.874599989657185 0.170375184832792 no 2825 0.190895796709831 885 176925 Isolated from Daphnopsis sellowiana. SGTC_1005 4092-0690 4.4 µM -0.875203511508759 0.170208661113769 no 2826 0.190731591459026 917 1529343 SGTC_329 k048-0121 21.3 µM -0.87644150452084 0.169867400627601 no 2827 0.190395031698465 907 6832902 SGTC_20 0481-0013 4.944 µM -0.877017332635341 0.16970881960667 no 2828 0.190238611896561 893 182045 SGTC_2194 5927483 104.545 µM -0.877304114929137 0.169629876212334 no 2829 0.190160738890842 868 760979 SGTC_3130 9127414 49.47 µM -0.877611899267 0.169545177736273 no 2830 0.190077184774256 896 1494646 SGTC_3159 9100096 49.47 µM -0.877977503578078 0.169444603177376 no 2831 0.189977963611289 892 25236875 SGTC_1053 3366-3204 134 µM -0.878072941884659 0.16941835523409 no 2832 0.189952067900324 912 3632071 YPR165W RHO1 SGTC_3026 9090633 49.47 µM -0.879210855074437 0.169105601430139 no 2833 0.189643479919964 896 25236842 SGTC_786 4544-0069 423 µM -0.879291413503696 0.169083474123563 no 2834 0.18962164516557 888 748821 YLR208W SEC13 SGTC_2145 5634607 200 µM -0.880001143745393 0.168888610030738 no 2835 0.189429344977448 913 308662 SGTC_1327 1436-0082 2.18 µM -0.882069056263594 0.168321665325233 no 2836 0.188869732278562 911 15992205 SGTC_2236 dapsone 200 µM -0.88238158630148 0.168236087815322 no 2837 0.188785244973009 884 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2988 9073640 71.4286 µM -0.882655026031393 0.168161237041494 no 2838 0.188711344190447 896 9102229 SGTC_2481 5478948 45.16 µM -0.882952836020664 0.168079739587791 no 2839 0.188630877304998 891 77792 SGTC_1920 st075728 45.7 µM -0.883818332657133 0.16784303563924 no 2840 0.188397144196368 854 3400306 SGTC_2638 epoxomicin 18 µM -0.888242165742298 0.166636519131152 no 2841 0.187205250928345 884 9915668 A protesome inhibitor. SGTC_1964 st076914 61 µM -0.888346545808279 0.166608119206369 no 2842 0.18717718470734 924 24208661 SGTC_1729 st035615 45.989 µM -0.890629015865389 0.165987881568077 no 2843 0.186564113764837 887 17385451 SGTC_1474 0330-0125 5.35 µM -0.891753377943363 0.165682897053342 no 2844 0.18626256803073 918 X1474 SGTC_911 3456-4043 236 µM -0.891991438768844 0.165618369289493 no 2845 0.186198760611007 889 914281 SGTC_2371 9071574 200 µM -0.892112890291929 0.165585455413155 no 2846 0.186166213190099 917 45596039 SGTC_1320 1313-0481 95.3 µM -0.893194822281867 0.165292433984988 no 2847 0.185876425194821 898 6813365 YLR208W SEC13 SGTC_1953 st076800 12.1 µM -0.893374629539095 0.165243769024702 no 2848 0.185828292188217 888 297591 SGTC_1750 st081859 2.357 µM -0.893891756599746 0.165103859911636 no 2849 0.185689904382231 890 5291695 SGTC_302 1094-0063 18.9 µM -0.894137297150764 0.165037455589812 no 2850 0.185624217937073 905 5440289 SGTC_2325 6158266 200 µM -0.896155530855062 0.164492297013202 no 2851 0.185084851122539 899 3623240 SGTC_2998 9066762 71.4286 µM -0.898134675283009 0.163958831910333 no 2852 0.184556877307275 890 4945196 SGTC_98 0074-0023 107.663 µM -0.898602963170972 0.163832772461118 no 2853 0.184432089912258 893 3563821 SGTC_1632 st005650 90 µM -0.899001478491307 0.163725544798327 no 2854 0.184325936568079 915 2759605 SGTC_1108 betulinic acid 729.144 nM -0.90028397027838 0.163380776769509 no 2855 0.183984574700062 877 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_509 pifithrin 175 µM -0.904930269128021 0.162135679889021 no 2856 0.18275116499733 925 4817 A p53 inhibitor. SGTC_1017 4239-0030 168 µM -0.907679138546913 0.161401965585944 no 2857 0.182023884458872 879 1149593 SGTC_2979 9012552 45.46 µM -0.910378049287421 0.160683695944626 no 2858 0.181311584963198 922 17100905 SGTC_3172 9105863 49.47 µM -0.911284313097279 0.160442977977142 no 2859 0.181072794800685 915 2348785 SGTC_532 1548-0774 215 µM -0.912233541475456 0.160191100712405 no 2860 0.180822895332238 935 5932993 SGTC_139 0099-0334 718.624 µM -0.912799722146795 0.160040988097051 no 2861 0.180673942246213 927 97690 SGTC_1235 benzylparaben 21.5 µM -0.913525316566317 0.159848744315151 no 2862 0.180483162466377 916 7180 SGTC_506 n9-isopropylolomoucine 153 µM -0.915588534357887 0.159302927554988 no 2863 0.179941373626804 911 6610355 SGTC_2942 9052777 62.25 µM -0.917340447792709 0.15884042449282 no 2864 0.179482134188765 920 6469503 SGTC_338 4055-0136 114 µM -0.919334789606016 0.158314992925782 no 2865 0.178960243161207 914 2900563 SGTC_827 3253-0474 693 µM -0.919362668243442 0.158307656079506 no 2866 0.178952954490855 901 5402065 SGTC_7 0192-1582 4.227 µM -0.919492356471306 0.15827352884386 no 2867 0.178919050887096 935 252616 SGTC_2455 5377712 9.75 µM -0.920393931062803 0.158036414470898 no 2868 0.178683469475983 867 2243908 SGTC_1175 0741-0056 27.6 µM -0.920471779298071 0.15801595130596 no 2869 0.178663136899026 910 765927 SGTC_3350 9150499 3.57 µM -0.921661057374878 0.157703554290677 no 2870 0.178352699729528 922 4910996 YPR165W RHO1 SGTC_829 1635-0120 117 µM -0.922827509721153 0.157397547460411 no 2871 0.178048551117353 896 285054 SGTC_1842 st055362 61.2 µM -0.922840445496491 0.157394156081763 no 2872 0.178045179990903 887 676032 SGTC_2789 5281112 71.43 µM -0.92383472676357 0.157133628594819 no 2873 0.177786185849018 906 765948 SGTC_1225 1216-0074 20.6 µM -0.924810734090912 0.156878165338807 no 2874 0.177532183046643 914 4241466 SGTC_1317 1273-0028 910 nM -0.924849521788775 0.156868018572626 no 2875 0.177522093406036 895 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2511 berberine 10.47 µM -0.925728357514474 0.15663823304763 no 2876 0.177293583481285 907 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_147 4466-0538 29.23 µM -0.925978168069657 0.156572956583012 no 2877 0.177228663063004 913 6742687 YHR072W ERG7 SGTC_1523 st012844 44.7 µM -0.928377151647462 0.155947004810881 no 2878 0.17660598312472 922 4274103 SGTC_510 ag-490 170 µM -0.929613925680326 0.155624946390037 no 2879 0.176285507318843 906 5328779 SGTC_1727 st034309 9.9045 µM -0.931625405298341 0.155102090681917 no 2880 0.175765074493428 937 870305 SGTC_2166 5933061 31.504 µM -0.932442428339165 0.154890048690356 no 2881 0.175553963263993 916 2877375 SGTC_1180 1193-0155 285 µM -0.933674867640911 0.15457055613919 no 2882 0.175235816469256 933 2921347 SGTC_138 0850-0259 40.9225 µM -0.934410704972098 0.154380008471864 no 2883 0.175046038922917 892 6813004 SGTC_2755 lomerizine 42.69 µM -0.934972995315315 0.15423450613559 no 2884 0.174901108268997 896 3949 A calcium channel blocker. SGTC_143 4032-1194 15.74 µM -0.935112599547284 0.154198395188506 no 2885 0.174865137002927 915 1806963 SGTC_1038 k292-0204 154 µM -0.935939214381877 0.153984692158512 no 2886 0.174652242670574 904 4454212 SGTC_3282 9108498 15.4605 µM -0.937061575917767 0.153694844171993 no 2887 0.17436344243464 934 16459645 SGTC_459 nigericin 15.3 µM -0.937177197045687 0.15366500574428 no 2888 0.1743337086538 922 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1657 st012939 43.4 µM -0.938270653679837 0.153383006265989 no 2889 0.174052668498043 887 24207257 SGTC_3356 9151811 4.48 µM -0.939406405244386 0.153090462238817 no 2890 0.173761062826289 923 1859254 YPR165W RHO1 SGTC_932 2857-0803 154 µM -0.940155651339554 0.152897675909662 no 2891 0.173568863158509 918 674898 SGTC_1789 tunicamycin 25 nM -0.940979290524064 0.152685933535914 no 2892 0.173357736035456 902 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1218 1348-1416 30.7 µM -0.947488142094929 0.151019473166134 no 2893 0.171695047901296 906 6787668 SGTC_1062 mesoridazine 14.2 µM -0.947927689668592 0.150907373811974 no 2894 0.171583133727147 893 4078 A neuroleptic. SGTC_2984 9022109 38.96 µM -0.948598017078652 0.150736524534629 no 2895 0.171412549954689 934 6459207 SGTC_905 2-aminofluorene 215 µM -0.949979386524901 0.150384855176643 no 2896 0.171061363399794 914 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2260 7964312 200 µM -0.950093560910069 0.150355813113149 no 2897 0.171032357368323 919 231951 SGTC_1898 st060199 18.6 µM -0.951074913961914 0.150106344530404 no 2898 0.170783174122883 887 688866 SGTC_1913 st060213 96.1 µM -0.952420469000983 0.149764741384081 no 2899 0.170441891308604 923 688959 SGTC_1431 4049-0260 9.09 µM -0.952848923317647 0.149656076369902 no 2900 0.170333311099524 923 3854841 SGTC_1955 wogonin 32.4 µM -0.952919406791877 0.149638205320484 no 2901 0.170315453205994 902 5281703 A flavanone. SGTC_2882 9058044 58.44 µM -0.953025128321402 0.149611402349698 no 2902 0.170288669547263 904 18076804 SGTC_2727 riluzole 51.77 µM -0.956196480386343 0.148808877044551 no 2903 0.169486488898313 928 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1710 st031758 61.5 µM -0.957953264195507 0.148365555281117 no 2904 0.169043162922906 919 5394341 SGTC_3212 9128307 49.47 µM -0.968462316141584 0.14573207234995 no 2905 0.166406765199266 932 27243542 SGTC_58 0957-0393 9 µM -0.969062009655108 0.145582747676201 no 2906 0.166257125542513 922 6997992 SGTC_3112 9123419 49.47 µM -0.969301076432769 0.145523248346644 no 2907 0.166197496189544 949 17015854 SGTC_1989 st071868 50.2 µM -0.971711444889676 0.144924265582704 no 2908 0.165597060732801 912 16414057 SGTC_638 3970-0837 4.09 µM -0.972563709477871 0.144712873410635 no 2909 0.16538509327567 902 4118451 YLR208W SEC13 SGTC_889 0919-1524 82.7 µM -0.974564138795035 0.14421751138114 no 2910 0.164888254690014 923 3905452 SGTC_1019 4262-0212 3.4 µM -0.975946439181806 0.143875883926924 no 2911 0.164545503647235 919 4677213 SGTC_2111 5486399 200 µM -0.976016021144395 0.143858701595667 no 2912 0.164528262528387 899 689674 SGTC_1353 1498-1206 8.11 µM -0.976407388481582 0.14376208447752 no 2913 0.164431310779515 874 6756808 SGTC_200 k038-0079 37.545 µM -0.976610073003639 0.143712064825712 no 2914 0.164381115172772 954 3436683 SGTC_615 k087-0205 167 µM -0.977688470757641 0.143446129108765 no 2915 0.164114212846496 924 9642773 SGTC_2482 5981709 142.65 µM -0.980576398806382 0.142735595523445 no 2916 0.163400838811694 937 877755 SGTC_2118 5526350 200 µM -0.981732626134173 0.142451790369282 no 2917 0.163115793813478 933 743594 SGTC_2799 7812892 81.82 µM -0.982483274359556 0.142267742293893 no 2918 0.162930909446417 932 20205235 SGTC_1850 st056238 17 µM -0.983383599945248 0.142047207803931 no 2919 0.162709339382638 908 5393177 SGTC_1498 4478-3555 97.6 µM -0.984381608674669 0.141803016422903 no 2920 0.162463958653917 907 3437919 SGTC_3037 9091026 49.47 µM -0.98530730039956 0.141576773743678 no 2921 0.162236573922558 927 25236398 YIL048W NEO1 SGTC_1562 morin hydrate 59.1 µM -0.985403263964066 0.141553333871242 no 2922 0.162213013517913 916 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2471 5466956 24.79 µM -0.985948036507841 0.141420318629351 no 2923 0.162079306418886 916 724419 SGTC_16 erodoxin 22.806 µM -0.988723846777704 0.140743874251395 no 2924 0.161399136055906 927 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_73 0327-0325 16.231 µM -0.990953688876085 0.14020207104506 no 2925 0.1608540971803 869 53298 SGTC_3312 9133330 71.43 µM -0.99213189648379 0.139916364980857 no 2926 0.160566594409692 949 17617324 SGTC_2772 vinpocetine 57.06 µM -0.9925592167755 0.13981284102426 no 2927 0.16046240396281 938 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1036 k216-0215 33.5 µM -0.992746383148262 0.139767513911959 no 2928 0.16041678244024 864 622330 SGTC_1736 st036774 51 µM -0.993692219429946 0.139538608333315 no 2929 0.160186365911313 930 1272247 SGTC_196 k015-0023 18.111 µM -0.995107711381557 0.139196516068536 no 2930 0.159841940264148 912 5211998 SGTC_308 4092-1169 104 µM -0.996760788920202 0.138797727803154 no 2931 0.159440317618597 934 2268590 YDL196W YDL196W SGTC_1439 4092-1168 46 µM -1.00061677736021 0.1378705362171 no 2932 0.158506057891299 945 2886240 SGTC_315 k915-0449 187 µM -1.00220055967177 0.137490934881396 no 2933 0.158123368779984 913 20970215 YNL149C PGA2 SGTC_1480 1070-0044 41.2 µM -1.00482590605948 0.136863264194615 no 2934 0.157490343607639 928 3124987 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.00689568280698 0.136369802441266 no 2935 0.156992453428444 932 688664 SGTC_1064 honokiol 6.76 µM -1.00737548889321 0.13625558441909 no 2936 0.156877182822648 943 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2897 9048598 12.99 µM -1.01049909025982 0.135513610299588 no 2937 0.15612811753492 936 6467404 SGTC_853 0419-0306 21 µM -1.01225428163767 0.135097902706971 no 2938 0.155708244131063 928 762713 SGTC_1937 st074714 47.2 µM -1.01296709584707 0.134929326459631 no 2939 0.155537938939087 942 17250970 SGTC_1361 1608-0041 5.61 µM -1.01317306249189 0.13488064347571 no 2940 0.155488752389117 927 X1361 SGTC_2552 juarezic acid 87.02 µM -1.01524439161141 0.134391726917523 no 2941 0.154994672329613 941 1549512 SGTC_401 neomycin 50 µM -1.01724467626601 0.133920735997651 no 2942 0.154518523833315 906 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2234 tolnaftate 200 µM -1.01764680328869 0.133826187499414 no 2943 0.154422918217052 957 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_566 0958-0068 16.5 µM -1.02063245576157 0.133125632964239 no 2944 0.153714303277975 912 6815365 SGTC_582 0987-0078 156 µM -1.02290583547901 0.132593901804551 no 2945 0.153176185072756 947 1625765 SGTC_922 1866-0035 480 µM -1.02414022786776 0.132305797857286 no 2946 0.152884522982588 919 3156169 SGTC_1607 st000305 50.6 µM -1.02515658634465 0.132068906574547 no 2947 0.152644654523166 955 5457690 SGTC_2326 6164455 177.58 µM -1.02942630488724 0.131076923321642 no 2948 0.151639696712004 944 2888790 SGTC_2544 sphondin 68.51 µM -1.03150058417652 0.130596868637487 no 2949 0.151153067206535 917 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2018 5133068 143 µM -1.03195451023068 0.13049197793382 no 2950 0.151046714083166 936 785362 SGTC_1930 st074634 34.3 µM -1.03810729730804 0.129075971719692 no 2951 0.149610052243132 943 684253 YOR116C RPO31 SGTC_2766 oltipraz 83.91 µM -1.03857923198171 0.128967802009163 no 2952 0.149500234328506 893 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1873 rapamycin 2 nM -1.0392125782 0.128822734810533 no 2953 0.149352940954678 915 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2997 9067075 71.4286 µM -1.04085158042253 0.128447848920598 no 2954 0.148972218346396 925 27209819 SGTC_1495 4469-0029 237 µM -1.04118351441351 0.128372018592489 no 2955 0.148895192669922 929 793680 SGTC_860 0443-0016 25.1 µM -1.04119867324669 0.128368556298938 no 2956 0.148891675680205 929 5337942 SGTC_2289 7946404 165.07 µM -1.04229522468571 0.128118274738217 no 2957 0.148637412824474 926 1246120 YPR165W RHO1 SGTC_2138 5575593 77.673 µM -1.046906927986 0.127069391171238 no 2958 0.147571253140912 943 762213 SGTC_2019 4016004 108 µM -1.04852474683211 0.126702855058409 no 2959 0.147198453406942 953 45595336 SGTC_1658 st012944 20 µM -1.05121406162359 0.1260951892399 no 2960 0.146580143171605 940 24207260 SGTC_1071 trifluoperazine 6.31 µM -1.05605773021631 0.125005866369788 no 2961 0.145470920270339 972 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1455 4262-0120 131 µM -1.0561421979306 0.124986928394765 no 2962 0.145451626981985 938 1529587 SGTC_1445 4239-0156 97.7 µM -1.05647017809756 0.124913413023645 no 2963 0.145376729278735 970 4008346 SGTC_2903 5923464 63.88 µM -1.05912056744974 0.124320447780767 no 2964 0.144772437106515 945 2876576 SGTC_1087 pterostilbene 9.05 µM -1.05995320065938 0.124134571784906 no 2965 0.144582945356765 954 5281727 Similar to reservatol, lowers cholesterol. SGTC_1416 3966-0321 25.3 µM -1.06048230716915 0.12401655579185 no 2966 0.144462617473322 938 582530 YLR208W SEC13 SGTC_1366 1683-0113 21.9 µM -1.06183862925066 0.123714389926058 no 2967 0.144154474871011 955 708623 SGTC_2870 9038528 12.99 µM -1.06264410898247 0.123535186671093 no 2968 0.143971687942905 961 6463316 SGTC_2168 5727979 200 µM -1.06560622750255 0.122877738024365 no 2969 0.143300841450862 944 695210 SGTC_1292 0kpi-0043 232 µM -1.06583217863939 0.122827688582241 no 2970 0.143249755908727 943 3333905 SGTC_880 0833-0487 87.2 µM -1.06793699342416 0.122362147118872 no 2971 0.142774466981779 942 76075 SGTC_2818 7996756 12.99 µM -1.06958802578897 0.121997840675618 no 2972 0.142402393681411 971 2241621 SGTC_1286 0929-0070 131 µM -1.06986500666278 0.121936798509028 no 2973 0.142340038141893 938 1420408 SGTC_2200 6600604 21.907 µM -1.07047853185645 0.121801663740032 no 2974 0.142201983579041 977 2904777 SGTC_2783 7738165 71.43 µM -1.07066377500134 0.121760882860684 no 2975 0.142160318246522 946 17201110 SGTC_1301 naphtanilide LB 4.81 µM -1.07369910874643 0.121094026865007 no 2976 0.141478780480965 933 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_125 0133-0007 11.75 µM -1.07377308183959 0.121077807275503 no 2977 0.141462198638211 933 26541 SGTC_225 nsc-122657 1.016 µM -1.07406057540373 0.121014784980868 no 2978 0.141397766453921 954 275685 SGTC_2224 6650123 117.647 µM -1.07670992646286 0.120435099287674 no 2979 0.140804938161717 967 2908370 SGTC_1821 st053465 65.6 µM -1.0770069400147 0.120370233982896 no 2980 0.14073858262585 955 675086 SGTC_2339 9000433 200 µM -1.07825976871644 0.120096897379673 no 2981 0.140458922818939 947 2988954 SGTC_448 monastrol 171 µM -1.0787933634138 0.11998061298327 no 2982 0.14033992701292 947 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2250 alverine citrate 130 µM -1.07890349640031 0.1199566219769 no 2983 0.140315375018174 918 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1100 amiodarone 5.07 µM -1.08226272658934 0.119226482407172 no 2984 0.139567901609087 934 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2446 5162541 200 µM -1.0834782250216 0.11896306432246 no 2985 0.139298105439161 957 1549321 SGTC_2344 7990960 76.95 µM -1.08422516303687 0.118801394844756 no 2986 0.139132488682068 924 140813 SGTC_12 0849-0099 9.267 µM -1.09019999199031 0.117513769591314 no 2987 0.137812528443865 940 6071388 SGTC_3171 9103192 49.47 µM -1.09168780460942 0.117194675923605 no 2988 0.137485173686036 974 13018434 SGTC_1028 k015-0029 4.8 µM -1.09289868645177 0.116935429497942 no 2989 0.137219142543282 957 4588309 SGTC_2043 5101342 149 µM -1.09293488786207 0.116927685139183 no 2990 0.137211194498241 968 678451 SGTC_3102 9121669 49.47 µM -1.09521659214479 0.116440306588368 no 2991 0.136710879156936 973 41905072 SGTC_1109 tnp00067 928.257 nM -1.09691685171731 0.116078064501378 no 2992 0.136338870706704 955 676295 SGTC_1319 1306-0155 43.7 µM -1.09740123745694 0.115975012169487 no 2993 0.136233016360558 953 3122360 SGTC_317 4495-0002 170 µM -1.09762475353939 0.115927481368834 no 2994 0.136184189653042 945 15991618 SGTC_228 caffeine 993.056 µM -1.1016753445962 0.115068516764464 no 2995 0.135301419747491 948 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3074 9116018 49.47 µM -1.10211085932088 0.114976432082289 no 2996 0.135206739455265 987 17027303 SGTC_673 1082-0474 110 µM -1.10323058261445 0.11473991983476 no 2997 0.134963521739202 946 3098046 SGTC_793 0488-0545 106 µM -1.10338602046286 0.114707115038205 no 2998 0.13492978245621 956 292548 SGTC_1279 0874-0590 65.2 µM -1.10433898512199 0.114506139938523 no 2999 0.134723058763933 954 3523074 SGTC_2399 5884133 200 µM -1.10440442048364 0.114492349175958 no 3000 0.134708872050564 962 722445 SGTC_1437 4092-1038 11.6 µM -1.10886456171203 0.113555141790016 no 3001 0.133744306865261 961 3977136 SGTC_1188 1403-0014 4.57 µM -1.10955846690045 0.113409824944326 no 3002 0.133594668465611 931 9614867 SGTC_966 1300-0360 30.2 µM -1.11178343814079 0.112944768522069 no 3003 0.133115637231874 915 70588 SGTC_1198 1612-1005 86.7 µM -1.11532173688453 0.112208010895248 no 3004 0.132356286916755 973 6998509 SGTC_825 1988-2224 89.6 µM -1.11614349324016 0.112037394369757 no 3005 0.132180358746831 955 1180859 SGTC_2576 guaiol 23.12 µM -1.1169114634 0.111878112896682 no 3006 0.13201609135371 924 227829 SGTC_310 1273-0058 1.06 µM -1.11924293007078 0.111395545423657 no 3007 0.13151825767862 899 2734232 SGTC_2378 9074213 121.43 µM -1.11998575854034 0.111242108033298 no 3008 0.131359915482589 954 657714 SGTC_744 1594-0068 283 µM -1.12665944892139 0.109870384861841 no 3009 0.129943246818597 970 668392 SGTC_2112 5488546 200 µM -1.12779188794059 0.10963883109147 no 3010 0.129703910049175 997 600757 SGTC_1510 1123-0200 71.5 µM -1.13116909324338 0.108950363147246 no 3011 0.128991963867171 966 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_787 4152-0075 138 µM -1.13221113881566 0.108738563265804 no 3012 0.128772839122747 940 9566539 SGTC_2099 5377090 177.372 µM -1.13285536396109 0.108607770157812 no 3013 0.128637498604686 960 2243829 SGTC_546 peri-Naphthalide 147 µM -1.13322504765272 0.108532766647167 no 3014 0.128559879067221 935 223824 A penicillin ester. SGTC_1402 3909-7673 35.9 µM -1.13375781259965 0.108424741846361 no 3015 0.128448075844527 966 5328014 SGTC_2066 5222451 176 µM -1.13588224486763 0.10799475577123 no 3016 0.128002925022893 919 2281147 SGTC_2225 6654152 15.4 µM -1.13694752412059 0.107779605565746 no 3017 0.127780111692193 929 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1255 0566-0045 221 µM -1.13713610629003 0.10774155056556 no 3018 0.127740696030329 955 2788469 SGTC_557 1315-0110 16.2 µM -1.13932909157022 0.107299726983088 no 3019 0.127282959463241 960 6833801 SGTC_1473 k844-0725 134 µM -1.14126557633553 0.106910668158962 no 3020 0.126879711308672 957 54682906 SGTC_2387 9077560 195.08 µM -1.14199880997348 0.106763620264575 no 3021 0.126727257167902 967 5303272 SGTC_2267 7931562 200 µM -1.14367334308015 0.106428344867637 no 3022 0.12637956621572 965 934880 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.14375770388232 0.106411474265993 no 3023 0.126362067600772 948 688664 SGTC_804 1595-0054 20.9 µM -1.14395861708331 0.106371303114142 no 3024 0.126320399798591 972 761523 Stimulates phospholipase C. SGTC_2962 9082311 13.18 µM -1.14569277804524 0.106025025204577 no 3025 0.125961146557481 963 16459453 SGTC_1058 3448-5425 97.3 µM -1.14676389834193 0.105811550831448 no 3026 0.12573960677768 960 7279705 SGTC_751 0833-0568 350 µM -1.14728035581742 0.105708731896895 no 3027 0.125632885074284 972 6954252 SGTC_590 k048-0076 22.4 µM -1.1505727864397 0.10505495607275 no 3028 0.124954016982466 975 6832814 SGTC_2197 6588183 93.1375 µM -1.15630855995186 0.103923006595304 no 3029 0.123777484140653 949 884136 SGTC_246 cycloheximide 667 µM -1.15680400016106 0.103825648558245 no 3030 0.123676223586951 956 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2343 7990716 14.84 µM -1.1568958526225 0.10380760607341 no 3031 0.123657456695944 980 6456862 SGTC_1800 st050079 29.0735 µM -1.15708691411288 0.10377008334664 no 3032 0.123618426240426 959 3645560 SGTC_2054 5233173 129 µM -1.15734866740518 0.103718693372007 no 3033 0.123564968716789 850 6889 SGTC_864 0469-0573 172 µM -1.1605082310448 0.103099832865664 no 3034 0.122920972248143 993 689425 SGTC_2881 9058953 51.95 µM -1.16089763750011 0.103023746246058 no 3035 0.122841764867172 935 17122249 SGTC_93 0109-0045 59.227 µM -1.16359903796872 0.102497038887533 no 3036 0.122293270733861 979 88733 SGTC_1998 st075797 76.8 µM -1.16382771913033 0.102452541670909 no 3037 0.12224691820828 936 24208315 SGTC_18 0111-0177 500 nM -1.16409241237104 0.102401054695273 no 3038 0.12219328161617 976 721752 SGTC_1013 4112-3890 241 µM -1.1641666817865 0.102386611513129 no 3039 0.122178234868038 958 705171 SGTC_1622 st003707 19.4 µM -1.16513798314442 0.102197858778069 no 3040 0.121981572039626 944 10140899 SGTC_144 4161-2749 112.381 µM -1.16582651145104 0.102064210654121 no 3041 0.121842298004189 957 797501 YMR168C CEP3 SGTC_40 0327-0103 19.753 µM -1.16625496939783 0.101981108207155 no 3042 0.121755686854368 944 409036 SGTC_1386 3228-0095 33.8 µM -1.16629091585457 0.101974138377277 no 3043 0.121748422381789 971 870181 SGTC_2304 7443016 91.4 µM -1.16677467382107 0.10188037395998 no 3044 0.121650688645728 972 939854 SGTC_254 nsc-64875 3.808 µM -1.16728033712803 0.101782430832702 no 3045 0.121548588319747 971 56993 SGTC_2893 9048488 25.97 µM -1.16945752196038 0.101361509600457 no 3046 0.121109672991162 987 6467338 SGTC_1932 st074806 40.9 µM -1.16999462054548 0.101257866110219 no 3047 0.121001566843526 958 17251235 SGTC_2739 tacrine 100.86 µM -1.17740718144187 0.0998353493053055 no 3048 0.119516512437896 913 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1240 0356-0016 42.1 µM -1.18069840743983 0.0992084433392637 no 3049 0.118861277198708 919 4305613 SGTC_2777 climbazole 1.536 µM -1.18342663366624 0.0986909624405538 no 3050 0.118320053528511 974 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_806 3966-4455 5.86 µM -1.1858617513956 0.0982307484362806 no 3051 0.117838450097492 971 714982 SGTC_811 0416-0114 265 µM -1.18590908047912 0.0982218192912683 no 3052 0.117829103388172 946 6612453 SGTC_3254 9136651 49.47 µM -1.19192595094564 0.0970915082716871 no 3053 0.116645140810722 988 16454030 SGTC_730 1436-0052 41.2 µM -1.19237088688934 0.0970083046134542 no 3054 0.116557925240815 959 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2330 7979373 200 µM -1.19487585843338 0.0965408480222037 no 3055 0.116067768188955 959 1863007 SGTC_2465 5809242 33.21 µM -1.19780373501004 0.0959965725002003 no 3056 0.115496716409486 1013 2731748 SGTC_3220 9131269 49.47 µM -1.1988013971916 0.0958116292009743 no 3057 0.115302589583339 979 17722206 SGTC_2006 4011487 200 µM -1.19967030375509 0.0956507678448904 no 3058 0.115133705300129 973 45595294 SGTC_2813 7971799 71.43 µM -1.20446434654535 0.0947668145910859 no 3059 0.114205077227228 978 2234054 SGTC_664 1222-0054 14.9 µM -1.20659575196349 0.0943757527282334 no 3060 0.113793931769096 979 6813991 SGTC_960 1222-0186 7.7 µM -1.20731054416009 0.0942448723055506 no 3061 0.113656285738804 981 3126296 SGTC_270 tamoxifen 5.46 µM -1.20797910639893 0.0941225779318545 no 3062 0.113527649578352 1014 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2700 st077718 96.8 µM -1.20836361305102 0.0940522964685003 no 3063 0.113453714784409 971 904970 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.20912812856066 0.0939126707141576 no 3064 0.113306812078896 974 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1896 st058441 89 µM -1.21351839780711 0.0931138233454503 no 3065 0.11246584235931 960 688759 SGTC_752 1896-0090 130 µM -1.22487183130959 0.0910712729332318 no 3066 0.110311757605634 989 772567 SGTC_3001 9076041 71.4286 µM -1.2254331082847 0.0909711648120795 no 3067 0.110206039445467 972 16004211 SGTC_1511 0906-3109 28.5 µM -1.22551078741532 0.090957316566977 no 3068 0.110191414080445 981 2882180 SGTC_2140 5586273 200 µM -1.22729331176519 0.090639966629187 no 3069 0.109856184251678 976 854421 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.23553776092085 0.0891828601387558 no 3070 0.108315215987297 981 688761 SGTC_393 acivicin 6.25 µM -1.23632757108027 0.0890441909451966 no 3071 0.10816841331567 945 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3223 9129970 49.47 µM -1.23954471628311 0.0884810056929801 no 3072 0.107571919776149 989 17248386 SGTC_2424 5537928 59.2 µM -1.23956020253465 0.0884783011422086 no 3073 0.107569054201374 964 5382802 SGTC_1221 2958-7315 257 µM -1.24061605629018 0.0882940498957211 no 3074 0.107373808812285 984 4562705 SGTC_878 0828-0289 13.7 µM -1.2422621334997 0.0880073726332832 no 3075 0.107069930813149 968 745350 YLR208W SEC13 SGTC_1514 1189-1591 158 µM -1.2427680246101 0.0879194073063082 no 3076 0.106976664306202 994 767698 YMR146C TIF34 SGTC_919 tnp00227 403.569 nM -1.24412535625909 0.08768371584385 no 3077 0.10672671510516 990 1269246 A methoxyflavone. YNL221C POP1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.24499434916499 0.0875330688030994 no 3078 0.106566913699081 991 688751 SGTC_1187 1391-0724 117 µM -1.24555799807172 0.0874354589698019 no 3079 0.106463355201022 992 6997986 SGTC_1610 st001799 48.1 µM -1.24691040460838 0.0872015874825847 no 3080 0.106215175627519 983 621897 SGTC_838 0109-0203 71.4 µM -1.24726187583026 0.0871408841492625 no 3081 0.106150745754992 968 759422 SGTC_2952 9073731 13.78 µM -1.24925051164599 0.0867980169519779 no 3082 0.105786731161418 995 16457353 SGTC_203 k066-0004 30.888 µM -1.25171788303577 0.0863740118876389 no 3083 0.105336340701986 1013 6795412 SGTC_3255 9139072 49.47 µM -1.25185147809856 0.0863510985427191 no 3084 0.105311994099068 978 17646060 SGTC_2092 5303694 80.6725 µM -1.25543555009147 0.085738077638476 no 3085 0.104660345405134 983 1963699 SGTC_2686 alizarin 95.37 µM -1.25910651402293 0.0851135779507252 no 3086 0.103995930954744 951 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1227 3909-8010 46.6 µM -1.25951312472486 0.0850446161022391 no 3087 0.103922526319682 988 15982272 SGTC_1443 4112-3303 14 µM -1.26179139935264 0.0846589914692429 no 3088 0.10351192889823 987 704433 SGTC_2383 9036125 200 µM -1.26186380769574 0.0846467570479224 no 3089 0.103498898583496 999 79580 SGTC_79 0052-0007 94.094 µM -1.26274100255059 0.0844986478021763 no 3090 0.103341136680098 948 2801472 SGTC_1838 st055369 84.5 µM -1.26403066316111 0.0842812492701972 no 3091 0.103109510681261 979 676036 SGTC_3134 9127454 49.47 µM -1.26412889084574 0.084264708215057 no 3092 0.103091884229368 1003 24262820 SGTC_604 1000-0114 314 µM -1.27328832069443 0.0827329890957705 no 3093 0.101457874798986 1000 1572745 SGTC_1840 st055363 71 µM -1.2738051545358 0.0826471882856246 no 3094 0.101366238977442 1011 676033 SGTC_2617 dihydrotanshinone i 20.83 µM -1.2774496287999 0.0820440606717529 no 3095 0.100721776505857 980 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1777 st045864 34.765 µM -1.27932630955962 0.0817347832628893 no 3096 0.100391085771256 1015 4691462 SGTC_2607 solasodine 47.35 µM -1.27935901868679 0.0817294005945434 no 3097 0.100385329114984 984 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2047 4141938 200 µM -1.28382152294667 0.0809975458583814 no 3098 0.0996022054903137 990 3807862 SGTC_274 sirtinol 40.1 µM -1.28386765180643 0.0809900065989273 no 3099 0.099594133728427 984 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_663 1486-0733 13.9 µM -1.2844299266047 0.0808981514832895 no 3100 0.0994957836724277 992 722445 YPR165W RHO1 SGTC_662 k832-1615 104 µM -1.285340655723 0.0807495385765717 no 3101 0.0993366345099621 994 5878478 SGTC_1962 st076595 64.5 µM -1.28992020171569 0.0800053707460796 no 3102 0.0985391829242417 985 279619 SGTC_3140 9094243 49.47 µM -1.29226167090154 0.0796268952961429 no 3103 0.0981332704381921 991 19291112 SGTC_493 zm226600 134 µM -1.2972385090809 0.0788269401377439 no 3104 0.0972745672489442 992 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2072 5231554 129 µM -1.29866535522189 0.0785987219713236 no 3105 0.0970293992446029 984 789545 SGTC_187 1488-2104 32.728 µM -1.30329460184378 0.0778617406969839 no 3106 0.0962371016673545 1000 2852859 SGTC_980 1473-0395 201 µM -1.30503850244189 0.0775854737852218 no 3107 0.0959398687799844 983 768876 SGTC_2969 9091408 28.7 µM -1.31382525430168 0.0762047970812601 no 3108 0.0944525084469759 984 4286311 SGTC_44 0929-0055 61.211 µM -1.31617471999432 0.0758388092958946 no 3109 0.0940577032907312 967 1379590 SGTC_1689 st020265 53.493 µM -1.31732779318588 0.075659679867341 no 3110 0.0938643864375489 1006 5758320 YPR016C TIF6 SGTC_984 1492-0255 2.91 µM -1.317778312604 0.0755897795051602 no 3111 0.0937889349704993 999 1585198 SGTC_1222 0366-0074 1.18 µM -1.31926755416961 0.0753590662920586 no 3112 0.093539840449938 1000 286520 SGTC_2171 5739187 198.077 µM -1.32374371175559 0.0746688510756723 no 3113 0.0927940879343606 977 2262761 SGTC_2802 7925815 54.55 µM -1.32488996435832 0.0744928793316118 no 3114 0.0926038249471171 986 1262923 SGTC_3221 9128209 49.47 µM -1.3268798521172 0.0741881454984969 no 3115 0.0922742150878356 995 16460723 SGTC_1952 st077036 64.1 µM -1.32984485252167 0.0737358492831772 no 3116 0.0917846972387759 981 2937007 SGTC_1242 0402-0103 60.1 µM -1.33076350684023 0.0735961416452412 no 3117 0.0916334196038226 981 432868 SGTC_1171 0368-0077 21.4 µM -1.33095719654363 0.0735667114422743 no 3118 0.0916015477198261 996 3239779 SGTC_361 000s-0510 1.45 µM -1.33260981603605 0.0733159698195353 no 3119 0.0913299410969059 975 660 SGTC_679 0422-0091 41.4 µM -1.33338332424475 0.0731988350883871 no 3120 0.0912030209860021 1010 627384 YHR062C RPP1 SGTC_2584 androsterone 48.74 µM -1.3359320128937 0.0728138923499298 no 3121 0.0907857481116662 935 2754130 A steroid. SGTC_1113 artemisinin 1.17947 µM -1.33765271364391 0.0725548829636879 no 3122 0.0905048360837549 975 2240 An anti-malaria and mitochondrial poison. SGTC_944 3370-0224 231 µM -1.33787924886547 0.0725208362662222 no 3123 0.0904679013281297 991 4580514 SGTC_430 0958-0115 16.4 µM -1.33904342374441 0.0723460617499878 no 3124 0.0902782684478945 986 6833180 SGTC_783 0848-0141 92.7 µM -1.33990197434008 0.0722173767135999 no 3125 0.0901386080775722 993 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2132 5317594 122.667 µM -1.34313912047096 0.0717337499528339 no 3126 0.0896134651212756 1010 794577 SGTC_2189 6047310 154.431 µM -1.34558232663749 0.0713703851610463 no 3127 0.0892186272419801 996 711535 SGTC_1050 3232-1156 69.3 µM -1.35294318378861 0.070284182863357 no 3128 0.0880368910401541 1003 700529 SGTC_620 0109-0052 432 µM -1.35377264169925 0.0701625854998863 no 3129 0.0879044622539495 1012 493037 SGTC_1802 st050112 57.9 µM -1.36136426231944 0.0690571708382752 no 3130 0.086699302023739 1008 4662563 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.3626672039405 0.0688688065920227 no 3131 0.0864937091501863 992 2724278 An inhibitor of dopamine biosynthesis. SGTC_2498 4'-Methoxychalcone 54.63 µM -1.36534662955193 0.0684826912780347 no 3132 0.08607206487187 1007 641818 YHR062C RPP1 SGTC_735 3076-0345 636 µM -1.36987827838002 0.0678334670955233 no 3133 0.0853624506794604 1002 2888990 SGTC_412 gemfibrozil 100 µM -1.37134843720645 0.0676238699523385 no 3134 0.0851331814983136 997 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1573 oleylamine 1.06 µM -1.37265816213661 0.0674375672562652 no 3135 0.0849293206958909 989 5356789 An amine of the fatty acid oleic acid. SGTC_1287 0971-0001 34.6 µM -1.37825168488595 0.0666463746168575 no 3136 0.0840627973413192 984 4665869 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.37865969963409 0.0665889440670796 no 3137 0.0839998502378366 1008 97141 SGTC_1368 1852-0141 284 µM -1.38259384693992 0.066037152593739 no 3138 0.0833947183987526 1014 2838987 SGTC_2026 5148700 152 µM -1.3831417847027 0.0659605823982079 no 3139 0.0833106978422545 1010 79838 SGTC_484 loperamide 105 µM -1.38453902086086 0.0657656405047422 no 3140 0.0830967342646007 1011 3955 An opioid-receptor agonist. SGTC_2930 9013230 14.89 µM -1.39464014237857 0.0643695933434029 no 3141 0.0815621917800089 972 2995857 SGTC_2178 5812956 200 µM -1.3968795064692 0.0640632382617494 no 3142 0.0812249041264686 999 5403383 SGTC_2883 9059145 45.46 µM -1.40362352845942 0.0631474708592194 no 3143 0.08021549250034 1025 16476510 SGTC_1726 st035556 14.5795 µM -1.40386160766233 0.0631153294721173 no 3144 0.0801800320402996 991 5919439 SGTC_2653 dihydrofissinolide 100 µM -1.40470148114268 0.0630020458427716 no 3145 0.0800550325788048 1024 6857746 SGTC_584 0986-0246 15.4 µM -1.40808266433383 0.0625475874482536 no 3146 0.0795532968295052 1025 53315 YDR232W HEM1 SGTC_3311 9131146 2.8755 µM -1.4118619007917 0.0620426564727678 no 3147 0.0789953138780789 1021 4900406 YPR165W RHO1 SGTC_208 k072-0098 12.366 µM -1.41270474423414 0.0619304819532797 no 3148 0.0788712780288273 1005 5948901 SGTC_778 3456-2434 196 µM -1.4134079787473 0.0618370092458414 no 3149 0.0787679004838149 906 5539063 SGTC_2414 st077232 92.9 µM -1.41714357553712 0.0613423251687316 no 3150 0.0782204772962336 996 729801 SGTC_354 2783-3500 4.88 µM -1.4202097881953 0.060938598725884 no 3151 0.0777733074387466 1001 6740761 SGTC_2580 diallyl disulphide 81.36 µM -1.42219089977 0.060678853600296 no 3152 0.0774854199348878 1004 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_722 3534-0461 190 µM -1.42230424373527 0.0606640192117651 no 3153 0.0774689737336062 1003 658262 SGTC_1768 st044301 37.178 µM -1.42415012931644 0.060422829911984 no 3154 0.0772015088634294 1034 3931349 SGTC_2012 4023501 200 µM -1.42437758327314 0.0603931620532634 no 3155 0.0771685998846208 1021 3477460 SGTC_1166 k206-0078 225 µM -1.43672662002384 0.0587994647529519 no 3156 0.0753978439758327 1001 5404595 SGTC_547 1120-0019 610 nM -1.43767471247993 0.0586784865794266 no 3157 0.0752631856495012 964 3676939 SGTC_2673 kobusone 100 µM -1.4384600945902 0.0585784185543002 no 3158 0.0751517761130052 1041 6710676 An epoxy ketone and protein crosslinker. SGTC_2612 dictamnine 15.46 µM -1.43893559922473 0.0585178981460832 no 3159 0.0750843850536834 975 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_332 4112-0506 40.9 µM -1.43921601783057 0.0584822305604543 no 3160 0.0750446642375339 1019 2790355 SGTC_1373 2887-0003 58.5 µM -1.44335001954009 0.0579583886030426 no 3161 0.074460947972214 1019 776948 SGTC_3301 9125354 19.7965 µM -1.44542227703944 0.0576971928447758 no 3162 0.0741696549062627 999 41905162 SGTC_22 0964-0034 14.468 µM -1.44634623403991 0.0575810323103119 no 3163 0.0740400570296467 1027 138402 SGTC_2408 sulbentine 18.36 µM -1.44713685722728 0.0574817807035248 no 3164 0.0739292984998328 984 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1374 2889-5571 141 µM -1.45597764362702 0.056381088749264 no 3165 0.072699399959749 985 2853281 SGTC_1253 0550-0034 176 µM -1.45786564710588 0.0561481960144422 no 3166 0.0724387895830265 1009 5969915 SGTC_964 1287-0107 19.4 µM -1.46019438962044 0.0558619819973024 no 3167 0.072118328407391 1013 51516812 YPR165W RHO1 SGTC_2965 9082772 38.63 µM -1.46796868403326 0.0549148112476153 no 3168 0.0710563647763462 876 16459634 SGTC_428 3448-4153 16.5 µM -1.47646392646148 0.0538943650134536 no 3169 0.069909696203574 1007 3834874 SGTC_1244 0416-0015 52.5 µM -1.47851777950509 0.0536499243889768 no 3170 0.0696346208960052 1024 96201 SGTC_521 r062-0005 13.8 µM -1.47943090967339 0.0535415300175162 no 3171 0.0695125920579168 1025 2832033 SGTC_77 0828-0286 12.516 µM -1.48039200101913 0.0534276298404654 no 3172 0.069384331729789 1004 745345 SGTC_2303 7774051 200 µM -1.48127018133177 0.0533237235133005 no 3173 0.0692672955536411 1019 2953184 SGTC_2603 homopterocarpin 100 µM -1.4818777117679 0.0532519342642919 no 3174 0.0691864182626311 1007 101795 A weak amylase inhibitor. SGTC_821 1114-0266 29.2 µM -1.48284506983784 0.0531377838750606 no 3175 0.0690577892251235 1013 3123235 SGTC_2389 9091542 195.52 µM -1.4839436888572 0.053008379774311 no 3176 0.0689119300914724 999 3626624 YOL127W RPL25 SGTC_411 enrofloxacin 100 µM -1.48497718614392 0.0528868744809202 no 3177 0.0687749337968517 1015 71188 A bacterial gyrase inhibitor. SGTC_2468 5987765 72.9 µM -1.49537386001065 0.0516768210827868 no 3178 0.0674084493373081 1024 26772094 SGTC_2655 perillic acid 100 µM -1.49586781334153 0.0516198828710061 no 3179 0.0673440526832177 1036 5702197 An apoptosis inducer. SGTC_299 1273-0059 1.44 µM -1.50023368978422 0.0511187925127357 no 3180 0.066776939634336 985 2848077 SGTC_2858 9025781 8.96 µM -1.5015721004056 0.0509659550265191 no 3181 0.0666038265763245 983 4894980 YPL153C RAD53 SGTC_893 0958-0369 48.9 µM -1.50463222606662 0.0506178758063158 no 3182 0.0662093281459952 1018 6819948 SGTC_2582 agaric acid 100 µM -1.50521666501907 0.0505516136496816 no 3183 0.0661341910025644 1005 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3005 9076496 71.4286 µM -1.51000802142074 0.0500109841719116 no 3184 0.065520688698589 1015 21368410 SGTC_2086 5274770 176.623 µM -1.51948464204187 0.0489552788444509 no 3185 0.0643202754588877 1016 689278 SGTC_3169 9102970 49.47 µM -1.52051545617853 0.0488415268541667 no 3186 0.0641907385769616 1057 17027839 SGTC_2975 9084847 53.72 µM -1.52137585261168 0.0487467425440455 no 3187 0.0640827725170885 1027 27211724 SGTC_2822 7994718 71.43 µM -1.52349392826949 0.0485140342400258 no 3188 0.0638175893026905 1054 1018011 SGTC_3163 9099914 49.47 µM -1.52904423034501 0.0479084469985609 no 3189 0.0631267396951918 1049 16268368 SGTC_2800 7887935 81.82 µM -1.53279125509416 0.0475030459371483 no 3190 0.0626636479958459 1042 2961002 SGTC_2274 7947094 46.08 µM -1.53426648062074 0.0473441931062009 no 3191 0.0624820541909543 1031 2971028 SGTC_1121 fusaric acid 630.51 nM -1.53892470553456 0.0468453864171782 no 3192 0.0619113394973411 1024 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3247 9135149 49.47 µM -1.54196995577228 0.0465215832371692 no 3193 0.0615404473305925 1012 8934436 YOR116C RPO31 SGTC_3138 9097216 49.47 µM -1.54479429584213 0.0462228774994841 no 3194 0.0611980137390113 1025 25237486 SGTC_2467 5474540 200 µM -1.55177032516317 0.0454916816281958 no 3195 0.0603585943812533 1009 5413519 SGTC_1740 st038286 13.222 µM -1.5525233790738 0.0454133092629822 no 3196 0.060268521566637 1014 716786 SGTC_149 3970-0822 46.1 µM -1.56272104386474 0.0443626657182321 no 3197 0.0590591112228843 1018 3114250 YBL034C STU1 SGTC_116 0155-0182 31.788 µM -1.56310114947033 0.0443238861399828 no 3198 0.0590144026598065 915 771486 SGTC_2090 5301565 104.445 µM -1.56321064829083 0.0443127197934787 no 3199 0.059001528179736 1029 2056344 SGTC_1583 clindamycin 39.6 µM -1.56752397389417 0.0438746610175571 no 3200 0.0584961334994878 1041 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2698 st077697 67.5 µM -1.57214645446114 0.0434090890949352 no 3201 0.0579582950528815 1030 3154499 SGTC_3051 9093778 49.47 µM -1.57243876310281 0.0433797826374915 no 3202 0.0579244152285655 1053 17217378 SGTC_709 3807-1509 243 µM -1.57420432804169 0.0432031090230712 no 3203 0.0577201095467911 1049 1886677 YPL242C IQG1 SGTC_2704 st078022 71.1 µM -1.57475017808587 0.0431486055654004 no 3204 0.0576570602777753 1028 54697681 SGTC_1044 1222-0021 1.78 µM -1.57626959140449 0.0429971836404047 no 3205 0.0574818432304863 978 4306703 SGTC_936 3005-4620 401 µM -1.57778299147921 0.0428467880638624 no 3206 0.0573077362831285 1021 777207 SGTC_989 1501-0895 10.3 µM -1.57882899059701 0.0427430895878343 no 3207 0.0571876435241914 1019 2830112 SGTC_1358 1509-0022 2.48 µM -1.58559830468564 0.0420768874136847 no 3208 0.0564152305340309 1034 3258434 SGTC_1992 st073643 23.3 µM -1.59947497784852 0.040737487069773 no 3209 0.0548575520591064 1044 3161292 SGTC_2264 7948757 110.76 µM -1.60390284802076 0.040317456068157 no 3210 0.0543677344809246 1040 2971411 SGTC_237 nikkomycin 200 µM -1.60864193997032 0.0398718060726136 no 3211 0.0538473290055241 1047 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_647 0140-0236 81 µM -1.60950951097634 0.0397906575143119 no 3212 0.0537524885057095 1051 990837 SGTC_2265 7929201 200 µM -1.61021975472829 0.0397243246121766 no 3213 0.0536749451153013 1028 1265108 SGTC_2142 5622915 118.518 µM -1.61481194083818 0.0392976064346317 no 3214 0.0531757132441292 1024 5322196 SGTC_1785 bathophenanthroline 24 µM -1.61579885749528 0.039206388200434 no 3215 0.0530689043329498 974 72812 An iron chelator. SGTC_3335 9143315 29.6265 µM -1.62215934634596 0.038622630564152 no 3216 0.0523846169021219 1019 4899691 SGTC_414 piperonyl butoxide 100 µM -1.6243664413102 0.0384217289172468 no 3217 0.0521488124140296 1040 5794 A potent inhibitor of cytochrome P450. SGTC_951 1171-0579 82.7 µM -1.62632955728007 0.0382437521131077 no 3218 0.0519397836349512 1021 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1901 st060216 58.6 µM -1.62854348285435 0.0380438439967363 no 3219 0.0517048484924251 1024 688792 SGTC_1360 1598-0022 39.8 µM -1.64074273908869 0.0369575399060419 no 3220 0.0504254145209849 1044 761525 SGTC_474 dl-dihydrosphingosine 5 µM -1.65483444882825 0.0357344213127335 no 3221 0.0489790420238667 1019 3058739 A sphingolipid protein kinase C inhibitor. SGTC_221 trifluoperazine 10.304 µM -1.65753101983367 0.0355041907221724 no 3222 0.0487060813816757 1030 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_515 4092-1064 102 µM -1.6657115256015 0.0348131782299924 no 3223 0.0478854426258386 1057 717353 SGTC_1224 0823-0416 294 µM -1.66854483729384 0.0345764364436874 no 3224 0.0476038094607653 1031 3598164 SGTC_2712 st079126 47.7 µM -1.67523565541875 0.0340226205166241 no 3225 0.0469440022062043 1040 3152970 SGTC_688 0527-0193 473 µM -1.67679235426327 0.0338948201359011 no 3226 0.0467915466818365 1061 4007154 SGTC_3241 9133421 49.47 µM -1.68072200916822 0.0335739628640125 no 3227 0.0464084617611375 1077 17018221 SGTC_1103 duloxetine 36.1 µM -1.68844776813497 0.0329504411858035 no 3228 0.0456626537130324 1059 60835 A selective serotonin reuptake inhibitor. SGTC_350 k064-0020 19.8 µM -1.69859543570196 0.0321459860156152 no 3229 0.0446977185260631 991 2790705 SGTC_1487 3970-0795 2.82 µM -1.69875474597733 0.0321334871491395 no 3230 0.0446827017699061 1029 3765103 SGTC_2575 plumbagin 510 nM -1.70253606083065 0.0318379956316795 no 3231 0.0443274622475015 1033 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2173 5763948 167 µM -1.70585893752943 0.0315801851291508 no 3232 0.0440171733015557 1048 2867177 SGTC_3256 9138902 49.47 µM -1.71295034410896 0.0310357554592428 no 3233 0.0433608376184047 1067 17228773 SGTC_754 3474-0146 171 µM -1.71692433264637 0.0307340705875041 no 3234 0.0429964991676281 1033 24762078 SGTC_1552 6-methylflavone 10.6 µM -1.72255314010433 0.0303109191178753 no 3235 0.0424846826126465 1049 689013 SGTC_1770 st043884 66.3 µM -1.7247503285389 0.0301470586175126 no 3236 0.0422862383931815 1051 670149 SGTC_1564 D-Arginine 115 µM -1.73185408235615 0.0296222972106201 no 3237 0.0416497730177923 1044 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1911 st060208 74.3 µM -1.73633016720052 0.0292955541859222 no 3238 0.0412527360404171 1049 688783 SGTC_2809 7964133 12.99 µM -1.74537029350647 0.0286447711476301 no 3239 0.0404602165935693 1060 1253665 SGTC_490 phenamil 164 µM -1.75192633660694 0.0281803719614711 no 3240 0.0398932376303 981 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1677 st019204 53.9 µM -1.76694301256245 0.0271402455359777 no 3241 0.0386188863066417 1046 3945625 SGTC_1391 3442-0225 151 µM -1.76707263846108 0.0271314084038985 no 3242 0.0386080320671564 1055 5227075 SGTC_1024 4507-0395 26 µM -1.7698111366552 0.0269452741250891 no 3243 0.0383793040221363 1055 4201836 SGTC_2191 5911152 200 µM -1.7736492022657 0.0266861977232738 no 3244 0.0380605968726685 1050 2875902 SGTC_47 0149-0135 24.25 µM -1.77396737929522 0.0266648139007828 no 3245 0.0380342731252849 1055 5239155 SGTC_3123 9126162 49.47 µM -1.79533592737455 0.0252610997084831 no 3246 0.0363000970794695 1039 25239884 SGTC_607 4491-0986 66.8 µM -1.80194945462376 0.024839405907247 no 3247 0.0357766791795004 997 698981 YDR232W HEM1 SGTC_2067 5224629 34.075 µM -1.80376060876753 0.0247249577292237 no 3248 0.0356344217626426 1042 2835000 SGTC_472 calcifediol 10 µM -1.80875644269018 0.0244115581427529 no 3249 0.0352444249690806 1065 5283731 A vitamin D metabolite. SGTC_591 4299-0174 154 µM -1.80960147001196 0.0243588788820046 no 3250 0.035178805906184 1066 5509088 SGTC_483 fpl-64176 144 µM -1.80967180091434 0.0243544987379065 no 3251 0.0351733490088633 1064 3423 SGTC_3161 9100388 49.47 µM -1.81116641091359 0.0242615720352888 no 3252 0.035057547963665 1070 25236368 SGTC_2684 capsaicin 100 µM -1.82058254288016 0.0236829508375509 no 3253 0.034335169232245 1045 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1262 0737-0114 49.6 µM -1.82373627241053 0.0234917670187822 no 3254 0.0340959761779846 1056 765919 SGTC_1784 st039334 36.3 µM -1.83431957779424 0.0228596548975942 no 3255 0.0333032848407638 1047 3496984 SGTC_2773 thioridazine 9.09 µM -1.83722275547019 0.022688781840073 no 3256 0.0330885088508877 1054 5452 An antipsychotic. SGTC_2931 9014674 55.67 µM -1.84059043653674 0.0224919193300881 no 3257 0.0328408001324418 1060 2996810 SGTC_2044 5102272 200 µM -1.84276847545232 0.0223653675757887 no 3258 0.0326814106947656 1058 592666 SGTC_3229 9132204 49.47 µM -1.84331054596668 0.0223339648722536 no 3259 0.0326418411294398 1072 17682924 SGTC_476 mead acid 10 µM -1.84905074769871 0.0220037054084066 no 3260 0.0322252426343052 1071 5312531 An omega 9 fatty acid. SGTC_904 1141-0088 396 µM -1.85150459935911 0.0218637875032578 no 3261 0.032048496838989 1067 1378119 SGTC_3228 9131799 49.47 µM -1.86172364485136 0.0212891539584947 no 3262 0.0313210269719537 1071 17015818 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.86177211004052 0.0212864594095698 no 3263 0.0313176096585823 1065 5106787 A p450 inhibitor. SGTC_1981 st071826 47 µM -1.867572606165 0.0209660419535704 no 3264 0.0309108338603548 1046 11838600 SGTC_1692 fluoroquinolonic acid 71 µM -1.87190888694843 0.0207291820551251 no 3265 0.0306096049455622 1056 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1626 st003712 1.76 µM -1.87686532465324 0.0204612265578919 no 3266 0.0302682772208686 1053 24207035 SGTC_1123 mangostin 811.285 nM -1.88729454664289 0.0199069757074901 no 3267 0.0295603597659902 1032 5281650 An antioxidant. SGTC_1904 st060225 78 µM -1.8893571509136 0.0197988829550226 no 3268 0.029421994182444 1042 66595 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.9067575873705 0.0189066678311205 no 3269 0.0282759929415846 1069 390807 SGTC_469 w7 172 µM -1.90812617376713 0.018837967225329 no 3270 0.0281874552754359 1070 45115570 A P450 inhibitor. SGTC_1453 4237-0541 195 µM -1.92290427119197 0.018109564452871 no 3271 0.0272460366333268 1036 739892 SGTC_965 1291-5240 308 µM -1.92553332154467 0.0179825282223953 no 3272 0.0270813357114738 1060 2834598 SGTC_952 1185-0122 232 µM -1.92694014769091 0.0179148627455354 no 3273 0.0269935446932344 1046 678600 SGTC_902 1120-0002 2.07 µM -1.93201727253904 0.0176724663525999 no 3274 0.0266786870059053 1024 3280475 SGTC_1126 isoteolin 1.0172 µM -1.94141402286397 0.0172312182104537 no 3275 0.0261040393757394 1051 133323 SGTC_1783 st039459 87.517 µM -1.94744063926405 0.0169532055036551 no 3276 0.0257409649449578 1066 729761 SGTC_842 0271-0008 11.1 µM -1.94895349114499 0.0168840216479443 no 3277 0.0256504895764613 1053 1221709 SGTC_1493 4348-0038 111 µM -1.94906157625956 0.0168790880881747 no 3278 0.0256440358010188 1052 800424 SGTC_1547 harmine 94.2 µM -1.95096369146338 0.0167924673163219 no 3279 0.0255306825492634 1038 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1259 0671-0132 43 µM -1.95222501106002 0.0167352377500093 no 3280 0.0254557479931189 1053 X1259 SGTC_928 2764-0428 58.7 µM -1.9523587784776 0.0167291781489588 no 3281 0.02544781173218 1065 662578 SGTC_2775 cyproheptadine 69.59 µM -1.96013885669826 0.0163799589429918 no 3282 0.0249897813358472 1061 2913 A selective serotonin reuptake inhibitor. SGTC_1114 scopoletin 1.73284 µM -1.96152840933573 0.0163182485547321 no 3283 0.0249087071542086 1069 5280460 A coumarin with genotoxic properties. SGTC_674 0498-0004 451 µM -1.96189637278339 0.0163019405868542 no 3284 0.0248872751069677 1018 4231473 SGTC_1331 1472-0049 76.2 µM -1.97556973126121 0.0157057621708141 no 3285 0.0241017648333333 1054 24051409 SGTC_2071 5230951 39.92 µM -1.98244234690149 0.0154132358113711 no 3286 0.0237148770050804 1074 1799272 SGTC_1844 rapamycin 4 nM -1.99554184228945 0.0148686080720683 no 3287 0.0229919076652397 1014 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2334 9017922 200 µM -2.00791171904718 0.0143695886375536 no 3288 0.0223263368192465 1053 3163164 SGTC_2348 9022543 33.42 µM -2.01208115392596 0.0142046691234895 no 3289 0.0221056914791655 1040 3162678 YDL140C RPO21 SGTC_2133 5320837 200 µM -2.01667655660057 0.0140247922129693 no 3290 0.0218646389832383 1070 2841355 SGTC_1328 1441-0025 69.2 µM -2.02828689621834 0.0135790541055054 no 3291 0.021265487784933 1072 4562601 SGTC_304 1310-0298 97 µM -2.04669540231498 0.0128973864816981 no 3292 0.0203440004851218 1075 1550234 SGTC_380 3970-0968 6 µM -2.04785878806779 0.0128553184732712 no 3293 0.0202869190074643 1072 2891601 SGTC_504 lovastatin 124 µM -2.04947163793673 0.0127971941929473 no 3294 0.0202080092227765 1070 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_235 0330-0087 5 mM -2.05503388436238 0.0125984811823662 no 3295 0.0199378660067015 1073 46494818 YHR062C RPP1 SGTC_2417 cerulenin 830 nM -2.06269142788781 0.0123292857404232 no 3296 0.0195709774342863 1062 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.0802346453272 0.0117312838833907 no 3297 0.0187520079734025 1050 6857784 SGTC_3331 9141060 1.957 µM -2.08459263477779 0.0115866945778984 no 3298 0.0185531468084466 1066 4906567 YPR165W RHO1 SGTC_2869 9037858 32.47 µM -2.10214406617678 0.0110199277148409 no 3299 0.0177703288792082 1078 27187042 SGTC_2241 6772625 37.8075 µM -2.10647580531187 0.0108838157221736 no 3300 0.0175815213027688 1045 2285411 SGTC_1427 4048-4900 550 nM -2.15012803341549 0.00959182951246766 no 3301 0.0157725443610837 1075 24132586 SGTC_211 3455-0679 143.504 µM -2.15316675714283 0.00950710186563609 no 3302 0.015652787624972 1062 748649 SGTC_1250 0485-0349 40.2 µM -2.16827440704093 0.00909550431908694 no 3303 0.015068907235632 1062 6842794 YDL195W SEC31 SGTC_3057 9095946 49.47 µM -2.17109148213795 0.00902050541798682 no 3304 0.014962128897578 1081 24540043 SGTC_1273 0849-0096 14.1 µM -2.18215735868186 0.00873111664146896 no 3305 0.0145489605750748 1079 5286025 SGTC_2310 7668677 200 µM -2.18393658021532 0.00868535506420199 no 3306 0.0144834542872766 1065 2197143 SGTC_300 r073-0011 5.04 µM -2.18705416230107 0.00860567784785275 no 3307 0.0143692851516107 1086 2735780 SGTC_2459 5811157 9.22 µM -2.1948393430725 0.00840950261741177 no 3308 0.0140875620915947 1070 2870684 YBR192W RIM2 SGTC_177 1327-0068 8.361 µM -2.19507304191896 0.0084036749347053 no 3309 0.0140791793213536 1061 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1457 k015-0032 57.3 µM -2.20153412559012 0.00824395447182235 no 3310 0.0138491167908849 1074 4302660 SGTC_410 α-linolenic acid 100 µM -2.20796650177028 0.00808759854540642 no 3311 0.0136233041924207 1075 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1915 st067105 30.6 µM -2.21609832885923 0.00789366717053066 no 3312 0.0133423843412385 1063 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2865 9030313 51.95 µM -2.2201912386892 0.00779761408767204 no 3313 0.0132028943978708 1078 42562754 SGTC_2680 butyl paraben 22.24 µM -2.24158741582794 0.00731204036098997 no 3314 0.0124940250213983 1087 7184 An antifungal and steroid mimetic. SGTC_1098 clofazimine 15.1 µM -2.25104434847292 0.00710605409605867 no 3315 0.0121913643180961 1074 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1939 st074455 53.6 µM -2.26037203151401 0.00690791562850162 no 3316 0.0118990854141357 1077 1644229 SGTC_220 paclitaxel 373.376 µM -2.27113500448751 0.00668536434755775 no 3317 0.0115694032634397 1074 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1082 camptothecin 424.86 nM -2.29129874316859 0.00628543004393275 no 3318 0.0109730706279181 1038 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_303 1348-1668 34.2 µM -2.3063192905118 0.00600142395180806 no 3319 0.0105463990149187 1084 5380509 SGTC_520 3584-0023 682 µM -2.32185126972116 0.00571976868300553 no 3320 0.0101204727468549 1068 1340790 SGTC_1435 4092-0789 56.7 µM -2.33033526115048 0.00557092915531487 no 3321 0.00989421924494197 1082 2248285 SGTC_1104 tacrolimus 29.8 µM -2.3314334776895 0.00555191618103028 no 3322 0.00986525698698479 1068 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1556 plumbagin 1.48 µM -2.336749664192 0.00546069172802117 no 3323 0.00972610225742713 1031 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1947 st076332 61.6 µM -2.34873251378413 0.00525993781235496 no 3324 0.00941871692318038 1080 24208416 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.34934705447291 0.00524982144048353 no 3325 0.00940318429701725 1079 16486 A toxic proline analog. SGTC_1497 4476-2978 41.3 µM -2.35556854927568 0.00514837571114262 no 3326 0.00924719219103228 1078 1528379 SGTC_2656 pseudo-anisatin 100 µM -2.36741519955942 0.00496002104201534 no 3327 0.00895641226223958 1094 6708809 A neurotoxin. SGTC_1771 st048882 4.1505 µM -2.36991619271422 0.00492105056640318 no 3328 0.00889605886294603 1073 4580403 SGTC_306 1672-3436 11.6 µM -2.39255854658135 0.00458046657111887 no 3329 0.00836567924127877 1086 6797378 SGTC_1385 3091-4834 14.1 µM -2.41245978278539 0.0042986570817864 no 3330 0.00792264272293645 1082 4072814 SGTC_824 1304-0008 100 µM -2.47782717466922 0.00347886383565834 no 3331 0.00660925778864018 1081 768245 SGTC_1703 st026983 48.3 µM -2.5151273042986 0.00307675993196416 no 3332 0.00594947047631455 1083 1104023 SGTC_1638 st008370 60.6 µM -2.55875438028371 0.00265989304148302 no 3333 0.0052523966540397 1066 24207134 SGTC_514 4466-0038 2.65 nM -2.58384354649701 0.00244395130689701 no 3334 0.00488530525382175 1057 5722064 SGTC_2864 9034755 47.6 µM -2.59101231277134 0.00238523268420945 no 3335 0.00478470338175565 1087 4930451 SGTC_1539 benzyladenosine 56 µM -2.63121607099425 0.00207895437208842 no 3336 0.00425399625364185 1086 92208 A nucleotide analog. SGTC_2336 9001819 198.65 µM -2.63955512873265 0.00202007977599737 no 3337 0.00415074601212303 1067 2989602 SGTC_1942 st076330 65.2 µM -2.64791905472918 0.00196255382481223 no 3338 0.00404944572638269 1075 24208414 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.75986901288763 0.00132332495457823 no 3339 0.00289122705722653 1093 5357218 A potent inhibitor of glutathione S-transferases. SGTC_226 1,3-diallylurea 8.28947 mM -2.76853050253785 0.00128284595268741 no 3340 0.00281548572009271 1087 74537 YKL182W FAS1 SGTC_409 arachidonic acid 100 µM -2.78715909444958 0.00119959590586437 no 3341 0.00265861836206737 1085 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3227 9130768 49.47 µM -2.81209480953199 0.00109589561616637 no 3342 0.00246099965131404 1094 17720899 SGTC_2029 5175081 200 µM -2.87862776006945 0.000858104643096294 yes 3343 0.00199704731771279 1090 1380876 SGTC_1966 st070145 16.1 µM -2.95198938690315 0.000651538761022286 yes 3344 0.00157866891336049 1088 3748532 SGTC_2242 6630449 61.2675 µM -3.02814278299239 0.00048645662732376 yes 3345 0.00123030898106846 1089 691249 YDR170C SEC7 SGTC_145 3737-0113 38.366 µM -3.07328530006393 0.000407849040808179 yes 3346 0.00105857986008916 1090 6849351 SGTC_885 0865-0106 16.8 µM -3.077710036665 0.000400814767582074 yes 3347 0.00104298889721455 1089 2793380 SGTC_1155 4088-0394 48.2 µM -3.09149430129386 0.000379616253971339 yes 3348 0.000995759024836343 1092 2326248 SGTC_222 nsc-310342 10.666 µM -3.23933671040643 0.000209143075531483 yes 3349 0.000599040228247504 1095 432556 SGTC_1325 1431-0015 227 µM -3.26428606188072 0.000188671105596389 yes 3350 0.00054870152499768 1095 1103340 SGTC_2674 ligustilide 100 µM -3.67183812987028 3.1760443570064e-05 yes 3351 0.000120406098758518 1094 5319022 A signalling regulator. SGTC_2679 rapamycin 1 nM -5.24696750602801 5.48815835164495e-09 yes 3352 7.7311578604621e-08 1092 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2