SGTCid condition conc unit MCM21|YDR318W.score MCM21|YDR318W.strain.pval MCM21|YDR318W.strain.significant MCM21|YDR318W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2040 5100729 123 µM 13.3122519048312 3.84985578709159e-33 yes 1 9.8234730098668e-41 1 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_916 4466-0038 42 nM 8.7469131981583 2.22830705675745e-15 yes 2 1.09634118759943e-18 8 5722064 YGL116W CDC20
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 7.46745207820743 1.08667275176377e-11 yes 3 4.08812437877049e-14 20 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_212 3807-4682 38.772 µM 6.86158083151985 3.86201183284318e-10 yes 4 3.40513252712902e-12 18 3125501 YBL034C STU1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 6.59211333311441 1.72279186886028e-09 yes 5 2.16804687374883e-11 9 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_514 4466-0038 2.65 nM 6.45026768453409 3.69947559464131e-09 yes 6 5.58263818428575e-11 63 5722064
SGTC_996 3970-0799 1.8 µM 6.28469884821103 8.84903199691672e-09 yes 7 1.64244917291618e-10 31 6615648 YGL040C HEM2
SGTC_2584 androsterone 48.74 µM 6.12334579758483 2.02787091718137e-08 yes 8 4.58152662693254e-10 56 2754130 A steroid.
SGTC_3311 9131146 2.8755 µM 6.08550125787485 2.45600974630874e-08 yes 9 5.8063706374001e-10 59 4900406 YPR165W RHO1
SGTC_2999 9069765 71.4286 µM 6.05558215324389 2.85531532327312e-08 yes 10 6.99553734609285e-10 4 2097066
SGTC_1880 MG-132 525 µM 5.63472144531628 2.2069505840043e-07 yes 11 8.76707597684449e-09 6 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2991 9074669 71.4286 µM 5.09367613362756 2.49816174606188e-06 yes 12 1.7559324061908e-07 30 17333109
SGTC_2437 5741531 144.16 µM 5.0406411486962 3.13051412457227e-06 yes 13 2.3198738481493e-07 20 2262990
SGTC_1412 3909-8563 178 µM 4.912335847359 5.35531836126616e-06 yes 14 4.49988614300139e-07 1 23767530
SGTC_1356 1502-0781 85.8 µM 4.85770487198089 6.70487027762468e-06 yes 15 5.93771188866649e-07 7 567702
SGTC_43 0570-0105 72.5 µM 4.83476902446384 7.36325907960029e-06 yes 16 6.66501601841293e-07 56 1114046 YDL195W SEC31
SGTC_563 tetrahydrosecaminediol 614 µM 4.82399142443081 7.69351319208251e-06 yes 17 7.03567349323141e-07 7 334274 A psychoactive constituent of the cannabis plant.
SGTC_2357 9067248 200 µM 4.65250098234174 1.52787359074858e-05 yes 18 1.63966587913651e-06 8 9150235
SGTC_1375 2910-0797 186 µM 4.58051096198142 2.02413910174351e-05 yes 19 2.31920651414229e-06 17 742508
SGTC_1369 1866-0067 208 µM 4.56326394652276 2.16395546873433e-05 yes 20 2.51822154295037e-06 24 3531355
SGTC_2619 obliquin 87.91 µM 4.54284405194036 2.34134013035524e-05 yes 21 2.77501550910705e-06 115 6708593 A bioactive alkalod. YER133W GLC7
SGTC_229 benomyl 22.8748 µM 4.30549579452828 5.71457748343404e-05 yes 22 8.3306078003317e-06 25 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3217 9129673 49.47 µM 4.25742766131109 6.81058689328959e-05 yes 23 1.03396270515832e-05 29 17248312
SGTC_3350 9150499 3.57 µM 4.25178046498519 6.95162706175426e-05 yes 24 1.06038850990954e-05 42 4910996 YPR165W RHO1
SGTC_528 3492-0019 172 µM 4.21744896086738 7.8700429133208e-05 yes 25 1.23540860858082e-05 197 2869262
SGTC_3215 9129942 49.47 µM 4.123975569756 0.000109830729824889 yes 26 1.86194204791729e-05 10 17682944
SGTC_2790 5423970 71.43 µM 4.12020427179383 0.000111302041867223 yes 27 1.8926832235061e-05 64 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2932 9016711 44.54 µM 3.97874925033054 0.000181918777203148 yes 28 3.46393791676599e-05 47 7117328
SGTC_163 TUB2.036 7.546 µM 3.96205174397886 0.000192587644497054 yes 29 3.71542151485135e-05 105 15992207 YJR013W GPI14
SGTC_1388 3346-4487 254 µM 3.95484639718937 0.000197369744297487 yes 30 3.82919192847495e-05 25 3345614
SGTC_2485 5633444 17.78 µM 3.95200549776803 0.000199285530967471 yes 31 3.87494798609611e-05 42 5724239
SGTC_496 calpeptin 138 µM 3.92322602153999 0.000219697310206565 yes 32 4.36855565014369e-05 16 73364 A calpain inhibitor.
SGTC_2950 9072895 21.46 µM 3.90482293301161 0.000233755466722214 yes 33 4.7147200099131e-05 40 17332245
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.84489190922681 0.000285569096336337 yes 34 6.03027945924355e-05 47 688788
SGTC_2489 cantharidin 73.42 µM 3.80804616985506 0.00032253829813726 yes 35 7.00345626137394e-05 48 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_863 0466-0191 129 µM 3.80725466503632 0.000323379232426944 yes 36 7.02590124453063e-05 71 765160 YPR165W RHO1
SGTC_143 4032-1194 15.74 µM 3.77715906804286 0.00035690896756689 yes 37 7.93137135124095e-05 74 1806963
SGTC_1217 1183-1422 255 µM 3.77223579125489 0.000362692120323067 yes 38 8.08956252968424e-05 15 2849664
SGTC_871 0574-0004 149 µM 3.66489446516505 0.000512576926173579 yes 39 0.00012372029725982 57 9551173
SGTC_1529 apigenin 74 µM 3.61661121512317 0.00059717111873339 yes 40 0.000149242552369434 41 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_379 3970-0972 5.9 µM 3.605198763022 0.000618967281825725 yes 41 0.000155957054638568 48 2898042 YBL034C STU1
SGTC_2319 6033012 152.6 µM 3.5548669005491 0.000724140032533484 yes 42 0.000189085236984694 40 847246
SGTC_2760 etidronate 98.04 µM 3.55122088724518 0.000732364876196626 yes 43 0.000191724229056964 40 3305 A chelator and antioxidant.
SGTC_534 k292-0788 63.4 µM 3.4783685207043 0.000915852949016504 yes 44 0.000252237925649666 47 4146317
SGTC_2591 skatole 100 µM 3.45892307909866 0.000971516500242273 yes 45 0.000271169883303541 39 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2912 7964298 10.93 µM 3.45837400417287 0.000973132421236375 yes 46 0.000271723198007875 112 2975850
SGTC_3074 9116018 49.47 µM 3.43638832449656 0.00103989985994269 no 47 0.000294762667712662 26 17027303
SGTC_180 1486-1293 102.781 µM 3.4234063791268 0.00108127162133861 no 48 0.000309207749327194 55 4140536
SGTC_2889 9059656 51.95 µM 3.41099334031331 0.00112223626342174 no 49 0.000323633362087867 20 3949838
SGTC_1686 st019653 115.5 µM 3.41037404616224 0.00112431678302365 no 50 0.000324369204256925 21 97252
SGTC_2873 9040596 71.43 µM 3.40510737185726 0.00114215352926997 no 51 0.000330690218918856 71 6463863
SGTC_127 0180-0333 59.125 µM 3.38743588859341 0.00120391267711709 no 52 0.000352746017599188 72 771601
SGTC_360 0957-0399 1.01 µM 3.32123096838072 0.00146344218391996 no 53 0.000448106689881088 73 6752301 YPR165W RHO1
SGTC_1719 st032227 49.2 µM 3.26122605633775 0.00174175913391464 no 54 0.00055465782024958 48 3125804
SGTC_822 1487-0950 154 µM 3.25978918995094 0.00174897820873776 no 55 0.000557475256149853 37 1958375
SGTC_228 caffeine 993.056 µM 3.23645781691573 0.00187007333263825 no 56 0.000605115560573569 25 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2270 7924575 90.91 µM 3.16553807112536 0.00228640984390602 no 57 0.000773982016168363 45 1262135
SGTC_2761 levamisole 97.89 µM 3.16508017621208 0.00228935123282518 no 58 0.000775201113060397 43 26879 An alkaline phosphatase inhibitor.
SGTC_149 3970-0822 46.1 µM 3.14743584550391 0.00240533718121755 no 59 0.000823546229071036 163 3114250 YBL034C STU1
SGTC_1023 4482-3888 16 µM 3.14089616620892 0.00244965925768007 no 60 0.000842158680167372 49 3303168
SGTC_1949 st076024 69.1 µM 3.13015533974364 0.00252405947083814 no 61 0.000873569435529294 58 2921930
SGTC_115 0527-0192 112.043 µM 3.12021972510128 0.002594694632698 no 62 0.000903580915940748 130 4233931
SGTC_1186 1319-0216 26 µM 3.07013874540282 0.00297866441729957 no 63 0.0010697967530971 57 4565136
SGTC_369 0957-0393 4.5 µM 3.05310094049554 0.00312052640491549 no 64 0.00113244869544085 66 6997992
SGTC_1460 k062-0059 9.15 µM 3.03117146318629 0.0033120596311257 no 65 0.00121803433702124 51 1373085
SGTC_459 nigericin 15.3 µM 3.02560650687675 0.00336231629153714 no 66 0.00124067497655548 110 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_52 0329-0193 875 nM 3.0087569893532 0.00351868937429952 no 67 0.00131159421714027 71 3739292
SGTC_2054 5233173 129 µM 3.00587584036013 0.00354607249294817 no 68 0.00132408552072497 114 6889
SGTC_2521 angolensin 13.4 µM 2.98686487772331 0.00373160376743026 no 69 0.00140927134297332 45 821428 A flavenoid.
SGTC_3101 9120531 49.47 µM 2.96310845365345 0.00397565794779366 no 70 0.00152274622311199 89 24824904
SGTC_1047 2043-3044 82 µM 2.94901623881917 0.00412709470346967 no 71 0.00159393612520064 88 669592
SGTC_375 3970-0961 9.27 µM 2.9384615377345 0.00424387596779455 no 72 0.00164922791146153 69 2898222
SGTC_34 0469-0683 81.75 µM 2.93554501416708 0.00427666234749735 no 73 0.00166481148957898 77 3690923
SGTC_593 1203-0218 61.7 µM 2.92192412316586 0.00443280060901069 no 74 0.00173938139039981 50 3666956
SGTC_788 1182-0090 188 µM 2.90976372272024 0.00457647873592064 no 75 0.00180851042916694 154 5715185
SGTC_190 3970-0790 3.722 µM 2.8978687909943 0.00472102744409153 no 76 0.00187853866555648 39 2832352
SGTC_1979 st071809 45.3 µM 2.86705751512405 0.00511456021771726 no 77 0.00207153855548968 63 4976333
SGTC_3306 9127676 59.7925 µM 2.84913598765977 0.00535665941276102 no 78 0.00219190692657118 76 41905287
SGTC_1514 1189-1591 158 µM 2.83764872491419 0.00551714773219802 no 79 0.00227235842410336 114 767698 YMR146C TIF34
SGTC_2257 7960413 200 µM 2.83193346293773 0.00559857582792495 no 80 0.00231337376582735 135 2974689 YIL048W NEO1
SGTC_2358 9037157 4 µM 2.82588408250576 0.00568592537457982 no 81 0.00235751616972502 88 2388925
SGTC_2060 5238662 140 µM 2.82354526198 0.00572001955823271 no 82 0.00237478595744277 80 790130
SGTC_2658 polymyxin b sulfate 77.05 µM 2.81160170093458 0.0058969718710521 no 83 0.00246477519977579 102 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_535 2293-4129 48.2 µM 2.80873501755253 0.0059401596498631 no 84 0.00248682826818915 142 396118 YIL048W NEO1
SGTC_3285 9112818 20.8695 µM 2.79431867951883 0.00616162724935295 no 85 0.0026004598933246 79 17017947 YPR165W RHO1
SGTC_2279 7948423 32.93 µM 2.78704191624296 0.00627616844395559 no 86 0.00265957991349041 61 1247112
SGTC_1022 4477-0945 21.3 µM 2.78664617348971 0.0062824514085084 no 87 0.00266282965686941 82 4648966
SGTC_1875 nocodazole 6 µM 2.77993631273303 0.0063898306698354 no 88 0.00271847801251905 99 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_844 0330-0132 15.3 µM 2.75857530701881 0.00674256923432722 no 89 0.00290269636535671 59 2828079
SGTC_2534 helenine 20.12 µM 2.75582384147951 0.00678923338766205 no 90 0.00292722589725699 52 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_644 1498-1197 63.3 µM 2.74582765005772 0.00696117630095563 no 91 0.00301792315371725 100 6741615
SGTC_2161 5662504 8.5105 µM 2.72078312352391 0.00740895160641172 no 92 0.00325637371126811 88 2859334
SGTC_1257 0669-0121 16 µM 2.71567285220266 0.00750337601134861 no 93 0.00330706198007967 108 4307855
SGTC_2772 vinpocetine 57.06 µM 2.70638867986994 0.00767763829573174 no 94 0.00340096914563629 85 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1243 0416-0003 5.65 µM 2.68583060009012 0.00807623961389554 no 95 0.00361748798933945 111 2141977
SGTC_1373 2887-0003 58.5 µM 2.67786516495206 0.00823550383484295 no 96 0.0037046519244127 105 776948
SGTC_1672 st016598 6.51 µM 2.67302136494657 0.00833369596659181 no 97 0.0037585731378968 161 4665860 YNL267W PIK1
SGTC_910 3454-3003 490 µM 2.66345395124043 0.00853066845667418 no 98 0.00386714984530506 99 820824
SGTC_79 0052-0007 94.094 µM 2.64257052327584 0.00897485663820518 no 99 0.00411396641498606 100 2801472
SGTC_500 h-89 112 µM 2.6319619815213 0.00920816368514467 no 100 0.00424466810225593 106 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_491 tetrandrine 80.3 µM 2.61839157358947 0.00951433604486423 no 101 0.00441726812833847 57 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3322 9139058 2.11 µM 2.61838956639395 0.00951438198126283 no 102 0.00441729411466882 110 4908926 YPR165W RHO1
SGTC_474 dl-dihydrosphingosine 5 µM 2.61045201498891 0.00969756323415682 no 103 0.0045211328287517 115 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1995 st072814 61.1 µM 2.60756326901687 0.00976498991913236 no 104 0.00455946083317874 87 5769371
SGTC_2347 9049783 174.81 µM 2.58399311920916 0.0103306157522474 no 105 0.00488318713755519 128 6467988 YPL169C MEX67
SGTC_636 0kpi-0074 126 µM 2.58188807729544 0.010382494264858 no 106 0.00491307229959379 88 616434
SGTC_2935 9038016 29.96 µM 2.57748263021444 0.0104918014630123 no 107 0.00497614416548094 112 6463195
SGTC_3175 9106517 49.47 µM 2.57341738766656 0.0105935558313491 no 108 0.00503498421038495 84 41468073
SGTC_3331 9141060 1.957 µM 2.5688504254913 0.0107088927800075 no 109 0.00510182443678806 107 4906567 YPR165W RHO1
SGTC_1876 myriocin 605 nM 2.5642918828785 0.0108251060031954 no 110 0.00516932802861678 104 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2145 5634607 200 µM 2.55706026215769 0.0110117176250555 no 111 0.00527804642911159 74 308662
SGTC_1488 4013-0813 75.9 µM 2.5481662535415 0.0112450594498696 no 112 0.0054145424638218 57 2910057
SGTC_467 ro 31-8220 72.8 µM 2.54780313530526 0.0112546768063532 no 113 0.00542018129607268 188 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1938 st074717 56.4 µM 2.53500535432959 0.0115982293922528 no 114 0.00562228036634182 70 17250979
SGTC_480 am 92016 50 µM 2.53320150635492 0.0116473780160478 no 115 0.00565129787892318 93 2129 K+ channel blocker.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.52676915006333 0.0118241123490745 no 116 0.00575585715021861 122 521171
SGTC_2126 5251174 33.877 µM 2.52439038378592 0.0118900578077269 no 117 0.00579495718735563 161 790722
SGTC_2342 7990637 118.86 µM 2.521156119826 0.011980231503716 no 118 0.00584849713295004 134 2033102 YER133W GLC7
SGTC_1952 st077036 64.1 µM 2.51087302389036 0.0122708835277993 no 119 0.00602165036612773 127 2937007
SGTC_2368 9071271 200 µM 2.50827296930054 0.0123453347690265 no 120 0.00606614516781666 132 27209959
SGTC_2663 amphotericin b 100 µM 2.50700311564268 0.0123818383909109 no 121 0.00608798192127952 86 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2709 st078560 56 µM 2.49871425654531 0.0126224171962086 no 122 0.00623223847685913 83 17250903
SGTC_1714 st033236 13.627 µM 2.49799526106106 0.0126434750054414 no 123 0.00624489317329953 126 2916566
SGTC_108 0509-0257 621.132 µM 2.4945475691039 0.0127448733527427 no 124 0.00630589103790532 167 536624
SGTC_449 xestospongin c 11.1929 µM 2.49251777388431 0.0128048990923741 no 125 0.00634204910068464 174 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1654 st012436 41.8 µM 2.49006562443756 0.0128777408711165 no 126 0.00638597551580181 91 4323132
SGTC_3294 9122953 26.2835 µM 2.46345752177678 0.0136914643540344 no 127 0.00688020998192693 122 16459826
SGTC_31 0508-1974 57.237 µM 2.44843730003131 0.0141701131409751 no 128 0.00717386997472345 114 6810525
SGTC_3124 9127567 49.47 µM 2.44508709678255 0.0142788190824973 no 129 0.00724085824042882 108 17592030
SGTC_422 cantharidin 155 µM 2.44408234816715 0.0143115604209182 no 130 0.00726105570537244 192 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2367 9070478 135.38 µM 2.41746008308928 0.0152029494124116 no 131 0.00781462406052541 148 572802
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.41238357857114 0.0153782338940921 no 132 0.00792429902766101 133 5377381
SGTC_230 MPP+ 141.667 µM 2.41094184384924 0.0154283302390518 no 133 0.0079556926795433 125 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3277 9138724 49.47 µM 2.4023844547348 0.0157285689908015 no 134 0.00814428973240568 92 15943418
SGTC_304 1310-0298 97 µM 2.40157780359018 0.0157571273754684 no 135 0.00816226858500755 197 1550234
SGTC_1691 st019933 84.6 µM 2.39963802375353 0.0158259847713444 no 136 0.00820564573459689 107 6176082
SGTC_3303 9125618 40.5795 µM 2.39512035950349 0.0159873516967822 no 137 0.00830745512974666 192 22695467
SGTC_855 0428-0020 25 µM 2.38062831734991 0.0165145473231658 no 138 0.00864157026318371 109 6812414
SGTC_1732 st034308 51.822 µM 2.36915338690882 0.0169424764143834 no 139 0.00891442883729643 148 830119
SGTC_2019 4016004 108 µM 2.35711290409751 0.0174016543815244 no 140 0.00920882308443369 147 45595336
SGTC_940 3232-1287 54.8 µM 2.35571811656551 0.0174555268309183 no 141 0.00924347012050865 156 1585493 YIL048W NEO1
SGTC_2141 5621638 7.665 µM 2.35411779933179 0.0175175130503106 no 142 0.00928336307851187 116 2856238
SGTC_2065 5221596 34.26 µM 2.34355917361144 0.0179312160438539 no 143 0.00955036603731726 129 788581
SGTC_2546 rhodinyl acetate 100 µM 2.33748101274059 0.0181731250798634 no 144 0.00970709354029526 133 6708682
SGTC_1798 st045719 60.953 µM 2.33647461018718 0.018213446815481 no 145 0.00973325968615716 92 3980186
SGTC_2925 9010536 32.5 µM 2.33368565262938 0.0183255855931277 no 146 0.00980609394766558 204 2994177
SGTC_968 1309-0633 340 µM 2.32131149235122 0.0188302481390839 no 147 0.0101350192152527 122 3761976
SGTC_582 0987-0078 156 µM 2.3165687590821 0.0190267841693717 no 148 0.0102636174138257 257 1625765
SGTC_354 2783-3500 4.88 µM 2.31543772882462 0.0190739101500604 no 149 0.0102944943781575 181 6740761
SGTC_2551 apiole 73.87 µM 2.3112498601601 0.0192492686806708 no 150 0.0104095288803606 74 10659 A possible DNA adduct former.
SGTC_2564 betulinic acid 100 µM 2.31059435193102 0.0192768404080189 no 151 0.0104276357591813 187 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2301 7769476 200 µM 2.30609146906485 0.0194671475039552 no 152 0.0105527609465318 118 977820
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.30314240400424 0.0195926479668218 no 153 0.0106354160762168 149 2374 Ca(2+)-ATPase inhibitor.
SGTC_1142 3253-1408 9.78 µM 2.30103301678739 0.0196828359846774 no 154 0.0106948824565526 121 256655
SGTC_859 0439-0102 54.6 µM 2.29916398172071 0.0197630418864385 no 155 0.0107478147231605 146 610143
SGTC_3133 9127736 49.47 µM 2.29901444162432 0.019769471069883 no 156 0.0107520596323592 133 27243420
SGTC_1878 temozolomide 1 mM 2.29566552583632 0.0199139168814066 no 157 0.0108475065152297 103 5394 DNA alkylating agent.
SGTC_2080 5212524 12.4 µM 2.29311726636176 0.0200244277719609 no 158 0.0109206272903256 112 260183
SGTC_226 1,3-diallylurea 8.28947 mM 2.28626964443838 0.0203239702672995 no 159 0.0111192443013354 122 74537 YKL182W FAS1
SGTC_2920 7982904 15.77 µM 2.28379083435493 0.0204333356802673 no 160 0.0111919133002694 147 6456808
SGTC_810 3825-7150 143 µM 2.28043113241629 0.0205823618823939 no 161 0.0112910654678087 114 22330411 YGL099W LSG1
SGTC_1194 1488-0194 225 µM 2.25953643507554 0.021530002373518 no 162 0.0119250182714129 180 1391452
SGTC_2666 tannic acid 100 µM 2.2547681177325 0.0217513542413413 no 163 0.0120739437310611 181 16134267 A thiamine antagonist.
SGTC_2532 xanthone 78.9 µM 2.25231763973927 0.0218658546519334 no 164 0.0121511031083695 156 7020 An insecticide.
SGTC_2909 7941780 10.49 µM 2.24888788398522 0.0220269670099682 no 165 0.0122598150223476 160 1243215
SGTC_214 4373-3496 70 µM 2.2474232923797 0.0220960707383809 no 166 0.0123064939002864 259 3779166
SGTC_1267 0828-0272 9.49 µM 2.24490064661919 0.0222155255812322 no 167 0.0123872557161198 158 745334
SGTC_2947 9072639 7.68 µM 2.23984272066274 0.0224566756336208 no 168 0.0125505676644171 220 16488146
SGTC_1352 1496-0991 99 µM 2.2369898782517 0.0225936635707953 no 169 0.0126435007919231 156 3000039
SGTC_3226 9131256 49.47 µM 2.23490963136951 0.0226939965366407 no 170 0.0127116410632366 42 17178073
SGTC_168 3970-0862 530.542 µM 2.22528620903206 0.0231630466484747 no 171 0.0130310153298736 388 3135186
SGTC_2855 9016525 58.44 µM 2.21981497667211 0.0234333378482513 no 172 0.0132156649300786 170 43811474
SGTC_546 peri-Naphthalide 147 µM 2.21886259150192 0.0234806579587381 no 173 0.0132480370915422 155 223824 A penicillin ester.
SGTC_1036 k216-0215 33.5 µM 2.21713316926051 0.0235667913910277 no 174 0.0133069963885007 232 622330
SGTC_2134 5324836 1.464 µM 2.19916761359593 0.0244773857737294 no 175 0.0139330031324676 137 699272
SGTC_662 k832-1615 104 µM 2.19577445182027 0.0246526444340739 no 176 0.0140540455783763 172 5878478
SGTC_3300 9124615 50.48 µM 2.18489519306732 0.0252216786997646 no 177 0.0144482660266519 194 24824903
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.17883569995503 0.0255433621178292 no 178 0.0146719379247385 176 6708514
SGTC_1185 1319-0113 81.3 µM 2.17776433710661 0.0256005940128997 no 179 0.0147117931279904 136 4672763
SGTC_1065 prochlorperazine maleate 2.48 µM 2.17706931790691 0.0256377791237649 no 180 0.014737697946452 179 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_408 cantharidin 100 µM 2.17590079846234 0.0257003994921655 no 181 0.0147813395484473 190 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_839 0122-0028 230 µM 2.17314989121693 0.0258483248457241 no 182 0.0148845188687657 228 759448
SGTC_1902 st060212 70.5 µM 2.16870997506847 0.0260885763457462 no 183 0.0150523547994153 168 688944
SGTC_220 paclitaxel 373.376 µM 2.16720737275036 0.0261703065439212 no 184 0.015109522734837 118 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2470 5664817 21.68 µM 2.16374110994853 0.0263596618895979 no 185 0.0152421120186987 133 2859561
SGTC_878 0828-0289 13.7 µM 2.16303503729446 0.0263983733557477 no 186 0.0152692424413784 241 745350 YLR208W SEC13
SGTC_923 1900-2434 73.3 µM 2.15856393362494 0.0266446127072837 no 187 0.0154420066791838 200 5910570
SGTC_605 1315-0399 119 µM 2.15748943305205 0.0267040743120536 no 188 0.0154837747966717 197 24020461
SGTC_1147 3809-1045 12.3 µM 2.15725154113676 0.0267172539462727 no 189 0.0154930352610775 193 325925
SGTC_921 1561-0023 372 µM 2.15060984023984 0.0270874147979272 no 190 0.0157535039908549 172 24050882
SGTC_2273 7815444 169.05 µM 2.14600865606319 0.0273463533495342 no 191 0.0159361440492714 174 2824616
SGTC_3048 9093155 49.47 µM 2.1460011284314 0.0273467786638685 no 192 0.0159364443332842 119 25236002
SGTC_3190 9110366 49.47 µM 2.13779275748747 0.027813849208018 no 193 0.016266783545098 131 17123768
SGTC_1512 0259-0544 12.2 µM 2.13567023639345 0.0279357000532602 no 194 0.0163531510278149 211 18476
SGTC_1430 4049-0248 69.1 µM 2.13302126986263 0.0280883967851337 no 195 0.0164614907064449 202 22774488
SGTC_3253 9135987 49.47 µM 2.11664254810363 0.0290480367745641 no 196 0.0171450980892836 127 4182430
SGTC_3045 9092950 49.47 µM 2.1147690762435 0.0291595208565082 no 197 0.0172248168565169 192 44120432
SGTC_1644 st010134 20.9 µM 2.11177548606175 0.0293383970620524 no 198 0.0173528554294534 143 3818134
SGTC_1410 3909-8106 77.9 µM 2.1073263380469 0.0296059300828758 no 199 0.0175446509268572 141 1039210
SGTC_321 4534-3890 65.3 µM 2.09527971116678 0.0303404879209364 no 200 0.01807306747579 152 699746
SGTC_2961 9083290 32.55 µM 2.09012611162594 0.0306593152027953 no 201 0.0183032363231169 172 17741490
SGTC_2381 9035592 200 µM 2.08622818452507 0.0309022988804218 no 202 0.0184789791774236 184 4749657
SGTC_2106 5357045 167.29 µM 2.0470420602988 0.0334347087992943 no 203 0.0203269775027098 211 668842
SGTC_39 0986-0283 58.349 µM 2.03779654040892 0.034056478892246 no 204 0.0207851422547899 249 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_565 1418-0001 44.5 µM 2.03583795188038 0.0341894088924924 no 205 0.0208833150435991 240 2862145
SGTC_25 0118-0223 35.662 µM 2.03576059774676 0.0341946676843759 no 206 0.0208872004055279 195 5333628
SGTC_1753 st043925 64 µM 2.03530699507566 0.0342255184896984 no 207 0.0209099963858017 198 670181
SGTC_1201 1889-3372 45.9 µM 2.0308214369111 0.0345318275216105 no 208 0.0211365558076412 164 5392199
SGTC_861 0443-0273 110 µM 2.0246387278071 0.034957719140035 no 209 0.0214522372464895 189 6149169
SGTC_3080 9117754 49.47 µM 2.0245400777276 0.0349645493692613 no 210 0.0214573063266917 228 9550191
SGTC_2700 st077718 96.8 µM 2.00930998221309 0.0360322472479626 no 211 0.0222521349687617 155 904970
SGTC_975 1335-0046 28.5 µM 2.0009066639461 0.0366326974723908 no 212 0.0227012246480173 250 16486740
SGTC_631 k072-0230 41.5 µM 1.99422983737522 0.0371155972342175 no 213 0.0230634714136488 224 5773147
SGTC_2348 9022543 33.42 µM 1.99042860410593 0.0373928364201075 no 214 0.0232718707718513 227 3162678 YDL140C RPO21
SGTC_893 0958-0369 48.9 µM 1.98309093935538 0.0379327853425949 no 215 0.0236786362507081 256 6819948
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.97746495776427 0.0383510731051774 no 216 0.0239945488718186 260 5024745
SGTC_3145 9085516 49.47 µM 1.97576256559275 0.0384783832993863 no 217 0.0240908375301032 236 25236195
SGTC_2754 granisetron 64.02 µM 1.97260162557402 0.0387156817224316 no 218 0.0242704838334516 252 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3139 9095020 49.47 µM 1.96881571457597 0.0390014656959617 no 219 0.0244871285327305 139 25236292
SGTC_761 k216-0224 480 µM 1.96380759510843 0.0393821459434541 no 220 0.0247762044861429 224 1340404
SGTC_2783 7738165 71.43 µM 1.96320585881673 0.0394280882432403 no 221 0.0248111294360954 192 17201110
SGTC_3305 9127027 53.8275 µM 1.95968567659665 0.0396977269401543 no 222 0.025016270164038 234 41905295
SGTC_367 0335-0881 7.1 µM 1.9555403052236 0.0400171742547915 no 223 0.0252596654572231 293 23828853
SGTC_3054 9094397 49.47 µM 1.95367112661365 0.0401618971314491 no 224 0.0253700615224751 272 2598354
SGTC_1656 st012921 11 µM 1.95059174194243 0.0404012483419713 no 225 0.0255528151746486 194 6732821
SGTC_3032 9089427 49.47 µM 1.94986285191215 0.040458071948368 no 226 0.0255962339146226 220 17173707
SGTC_1657 st012939 43.4 µM 1.94958667871259 0.0404796191044428 no 227 0.0256127012105496 188 24207257
SGTC_1191 1487-1166 10.6 µM 1.94527412942308 0.040817296348019 no 228 0.0258709970343953 273 3955771
SGTC_3197 9113331 49.47 µM 1.94393300831012 0.0409227722369167 no 229 0.0259517650749697 265 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1558 st069300 45.6 µM 1.93758562995395 0.0414249812534661 no 230 0.0263368985231852 161 24208000
SGTC_2013 4024628 200 µM 1.93320962544259 0.041774113709869 no 231 0.0266051897463151 254 5230760
SGTC_1803 st050068 52.4 µM 1.93109943140143 0.0419433217361379 no 232 0.0267353786626216 500 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.9195894216072 0.0428760548983479 no 233 0.027454890646012 241 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_159 3970-0959 50 µM 1.9146735662568 0.0432794949239237 no 234 0.0277670733556246 462 6615653
SGTC_984 1492-0255 2.91 µM 1.91220682598921 0.0434830901868728 no 235 0.0279248354675526 237 1585198
SGTC_385 1494-0393 12.4 µM 1.91216437042477 0.0434866010618949 no 236 0.0279275572652294 250 3090647
SGTC_2085 5307070 144.047 µM 1.90835171116323 0.0438028241280318 no 237 0.0281728868066192 220 2840351
SGTC_620 0109-0052 432 µM 1.90526914214195 0.044059847275806 no 238 0.0283725472488748 243 493037
SGTC_8 0354-0001 70 µM 1.90406075846994 0.0441609329338521 no 239 0.0284511358195464 353 4993152
SGTC_818 4072-2707 53.5 µM 1.89551679322053 0.0448810116382986 no 240 0.0290119845354378 214 882871
SGTC_2122 5258151 111.688 µM 1.88832911869217 0.045494077762786 no 241 0.0294908902550654 267 2173356
SGTC_2958 9077254 16.72 µM 1.88626683380291 0.0456712163364648 no 242 0.0296295031212226 256 16457351
SGTC_1120 ficusin 1.78878 µM 1.88232097121867 0.0460116886274493 no 243 0.0298962244038401 256 6199 A DNA cross-linker.
SGTC_2762 leflunomide 42.06 µM 1.88093560814081 0.0461317084351738 no 244 0.0299903393337493 281 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3158 9100007 49.47 µM 1.87338095882542 0.0467906302708236 no 245 0.030507898740244 219 19297233
SGTC_2195 6536160 144.242 µM 1.86927449514449 0.047151953826936 no 246 0.0307923173163525 221 3834386
SGTC_1125 tnp00248 1.32998 µM 1.86879629341195 0.047194175320208 no 247 0.0308255803778209 364 24207736
SGTC_1673 st016611 27.3 µM 1.85767933363299 0.0481842854024233 no 248 0.0316072824989566 313 5226799
SGTC_801 0866-0028 10.1 µM 1.85637231996686 0.0483017759149407 no 249 0.0317002536601207 304 6849771
SGTC_493 zm226600 134 µM 1.85614666993866 0.0483220833016996 no 250 0.0317163275637921 263 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2095 5432005 200 µM 1.84781081529264 0.0490770669762029 no 251 0.0323148578918421 233 783734
SGTC_2004 4023728 41.89 µM 1.84756610362442 0.0490993722259525 no 252 0.032332568535657 299 360084 YDR527W RBA50
SGTC_1903 st060211 78.3 µM 1.84594291679067 0.0492475293124946 no 253 0.0324502471496097 296 688960
SGTC_1456 k015-0012 13 µM 1.84453366158886 0.0493764490189384 no 254 0.0325527023990071 313 2989616
SGTC_3201 9113999 49.47 µM 1.84261308551763 0.0495525783738739 no 255 0.032692760998207 280 16649224
SGTC_2856 9022925 19.48 µM 1.84075072818763 0.0497238471759957 no 256 0.0328290481452739 289 4944862
SGTC_1953 st076800 12.1 µM 1.83883302465045 0.049900699012231 no 257 0.0329698746166145 324 297591
SGTC_981 1488-1094 54.9 µM 1.83747991282079 0.0500257854426984 no 258 0.0330695395929127 208 3449522
SGTC_2433 5607874 27.82 µM 1.8299672735485 0.050724834385835 no 259 0.0336274163273592 300 2252428
SGTC_465 cgp-37157 41 µM 1.82920270193377 0.0507964115511005 no 260 0.0336846239187685 170 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_138 0850-0259 40.9225 µM 1.8290458029985 0.0508111099535168 no 261 0.0336963734762345 490 6813004
SGTC_5 0352-0601 109.883 µM 1.82887278086526 0.0508273227145788 no 262 0.0337093343479162 199 762456
SGTC_70 0141-0289 43.283 µM 1.82856866371585 0.050855829505709 no 263 0.0337321253251623 537 352408
SGTC_1424 4048-1941 275 µM 1.82191322700251 0.0514828783052083 no 264 0.0342340765062112 297 X1424
SGTC_3085 9117376 49.47 µM 1.82124724841507 0.0515459611020412 no 265 0.0342846406016163 275 16480349
SGTC_1360 1598-0022 39.8 µM 1.82089143628848 0.0515796895062538 no 266 0.034311680610006 355 761525
SGTC_2831 7999036 19.48 µM 1.81988439951336 0.051675244395755 no 267 0.0343883055713888 317 2988270
SGTC_181 1447-1644 8.07 µM 1.81931517167144 0.0517293190489916 no 268 0.034431680022656 284 534600
SGTC_2389 9091542 195.52 µM 1.81197351662035 0.052430789161457 no 269 0.0349951443422671 308 3626624 YOL127W RPL25
SGTC_3141 9094609 49.47 µM 1.81188122046297 0.0524396555703604 no 270 0.0350022758564659 291 25236309 YDL196W YDL196W
SGTC_1073 triclabendazole 3.09 µM 1.80868075036248 0.0527478449088919 no 271 0.0352503076158447 331 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_419 nsc-638432 893 µM 1.80488882699558 0.0531148462891645 no 272 0.0355460402671634 280 368090
SGTC_1518 st038567 90.8 µM 1.79853456167593 0.0537343799175765 no 273 0.0360461683849481 242 77966
SGTC_290 2043-6722 48.1 µM 1.78856057485532 0.0547183587043446 no 274 0.036842805993017 265 773758 YLR208W SEC13
SGTC_889 0919-1524 82.7 µM 1.78573526210405 0.0549996624048532 no 275 0.0370710665342137 278 3905452
SGTC_1165 k072-0275 30.3 µM 1.78245644555769 0.0553275506703036 no 276 0.037337413878903 284 6153523 YGL055W OLE1
SGTC_873 0591-4978 488 µM 1.78216934592266 0.0553563345588993 no 277 0.037360810021465 302 3305145
SGTC_1232 0279-0259 161 µM 1.77978235212287 0.0555961066539039 no 278 0.0375557934404016 295 1560000
SGTC_539 4859-0462 2.54 µM 1.7796824505674 0.0556061595495491 no 279 0.0375639720569759 273 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_26 0302-0163 425.158 µM 1.77487815837313 0.0560913017803447 no 280 0.03795900371438 252 3100915
SGTC_155 k072-0202 43.6 µM 1.77478608968394 0.0561006314618995 no 281 0.0379666070105015 251 5857737
SGTC_3245 9134821 49.47 µM 1.77465909540143 0.0561135022989804 no 282 0.0379770966010999 313 17014901
SGTC_2324 6149169 200 µM 1.77370650037254 0.0562101218127746 no 283 0.0380558553302349 255 2888231
SGTC_1892 st058411 7.36 µM 1.77319836171025 0.0562617147641905 no 284 0.0380979217206697 345 3934738
SGTC_316 k060-0003 58.6 µM 1.77110192701516 0.0564749673704792 no 285 0.0382718768186505 269 6152314
SGTC_1682 st012968 530 nM 1.77002354971421 0.0565849094271649 no 286 0.0383616088730251 247 24207270
SGTC_1717 st033143 58.0435 µM 1.76571999666417 0.0570253428305939 no 287 0.0387214181320153 340 674616
SGTC_1559 coumarin 343 70.1 µM 1.76375734816163 0.0572270978616974 no 288 0.0388864206331306 244 108770 A hepatotoxic, DNA x-linker.
SGTC_1849 st056239 19.2 µM 1.76352043952658 0.0572514893884297 no 289 0.0389063765355159 324 5393181
SGTC_1007 4101-0031 70 µM 1.76177438333168 0.057431511456165 no 290 0.0390537122429004 306 1146276
SGTC_3205 9113483 49.47 µM 1.75983723790322 0.0576317560108016 no 291 0.0392177036422849 339 17018033
SGTC_550 4123-0385 25.7 µM 1.75929471151515 0.0576879357875624 no 292 0.0392637321993054 293 5731123
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.75821787531377 0.0577995720571838 no 293 0.039355222438933 319 140250 A respiratory chain inhibitor.
SGTC_1755 st041960 45.185 µM 1.75698762869824 0.0579273202681385 no 294 0.0394599589533968 285 2257073
SGTC_1361 1608-0041 5.61 µM 1.75440958698519 0.0581957426184697 no 295 0.039680174892529 306 X1361
SGTC_3063 1327-0034 4 µM 1.75032837427851 0.0586226699763698 no 296 0.0400308337507936 292 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_150 3970-0969 77.2 µM 1.74875322664213 0.058788099070352 no 297 0.0401668425328854 394 6615640
SGTC_3321 9137793 26.8275 µM 1.74753527436376 0.0589162648919601 no 298 0.040272265835677 351 4904192
SGTC_377 3970-0964 33.1 µM 1.74738940887876 0.0589316290906066 no 299 0.0402849066904682 413 16481235
SGTC_3033 9090887 49.47 µM 1.74622862389215 0.0590540081376174 no 300 0.0403856164266358 354 19325384
SGTC_1734 st037168 69.4 µM 1.74543585815064 0.0591377022165776 no 301 0.0404545142222548 310 708907
SGTC_351 caspofungin 25 nM 1.7424189680385 0.0594570530782566 no 302 0.0407175796156751 453 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2309 7664088 163.95 µM 1.74170787431258 0.0595325219342894 no 303 0.0407797869726284 358 704922
SGTC_364 0083-0097 67.7 µM 1.72892698312978 0.0609018070829589 no 304 0.0419110820314358 306 5207356
SGTC_1534 6-azauridine 81.6 µM 1.72623058105699 0.0611938083462492 no 305 0.0421529692168591 366 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1640 st009078 66.4 µM 1.72488419193862 0.0613400217182529 no 306 0.0422741724840072 251 690618
SGTC_2012 4023501 200 µM 1.7220392294288 0.0616498727190397 no 307 0.0425312061740789 303 3477460
SGTC_489 paxilline 115 µM 1.71664349367064 0.0622408894166903 no 308 0.043022165226072 295 105008 A toxic potassium channel blocker.
SGTC_606 k015-0008 38.6 µM 1.71600580212294 0.0623110293752352 no 309 0.0430804902396188 342 1970475
SGTC_2823 7987624 58.44 µM 1.71027855451424 0.06294373775024 no 310 0.0436071877482953 373 2239440
SGTC_2152 5568786 200 µM 1.70603957586488 0.0634152465767477 no 311 0.0440003556853318 307 5399883
SGTC_1152 3909-8331 15.9 µM 1.70436044119208 0.0636027780292698 no 312 0.0441568847986625 291 16001939
SGTC_1350 1495-0454 146 µM 1.70384418915076 0.0636605214541281 no 313 0.0442050999944206 380 1069057
SGTC_2765 myclobutanil 7.74 µM 1.70169424775002 0.0639014337610973 no 314 0.0444063496474545 335 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_390 dec-rvkr-cmk 16.7 µM 1.69675403418755 0.0644576969540514 no 315 0.0448715861509469 342 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1661 st013063 9.66 µM 1.68692406498014 0.0655757247391361 no 316 0.045808977034829 354 721395
SGTC_3031 9088762 49.47 µM 1.68238375851112 0.066097174178437 no 317 0.0462472243674403 336 205253
SGTC_2100 5377183 190 µM 1.68152472053416 0.066196194189306 no 318 0.0463305194590162 346 2844202
SGTC_189 3970-0742 2.116 µM 1.67862636890205 0.0665311307648649 no 319 0.0466124420796672 272 2891807
SGTC_1325 1431-0015 227 µM 1.67604075754847 0.0668310325644563 no 320 0.0468651047525163 298 1103340
SGTC_2898 9056270 58.44 µM 1.67542752642504 0.0669023136854145 no 321 0.0469251897953516 254 19154699
SGTC_584 0986-0246 15.4 µM 1.6739887239799 0.0670697889267743 no 322 0.0470664077368463 355 53315 YDR232W HEM1
SGTC_2966 9084041 48.03 µM 1.67393026586061 0.0670766002444115 no 323 0.0470721525756944 332 17741380
SGTC_2917 7979103 53.79 µM 1.67131278613385 0.0673821275785231 no 324 0.0473299561081693 397 2980565
SGTC_1290 0986-0249 10.2 µM 1.66916946252519 0.0676331087806059 no 325 0.0475419001092733 293 53329
SGTC_1959 st077091 55.8 µM 1.66626750986226 0.0679740749461258 no 326 0.0478300724592795 375 821356 YKL052C ASK1
SGTC_397 arbidol 50 µM 1.66425130149729 0.0682117505633066 no 327 0.0480311099280552 351 131410 A RNA synthesis inhibitor.
SGTC_3114 9122766 49.47 µM 1.66284890840349 0.0683774459940609 no 328 0.0481713418370314 327 17176985
SGTC_84 0443-0269 128.823 µM 1.66052460093534 0.0686527510560732 no 329 0.0484044815355621 351 6150058
SGTC_2757 clomiphene 4.22 µM 1.6591325236601 0.0688180459719715 no 330 0.0485445454056619 388 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1994 st072947 40.9 µM 1.65727967369866 0.0690385287078995 no 331 0.0487314724188038 339 5286565 YDL195W SEC31
SGTC_3152 9099253 49.47 µM 1.65672005446104 0.0691052283960809 no 332 0.048788043268779 482 25236131
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.6561162048111 0.0691772554904964 no 333 0.0488491441461829 373 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2952 9073731 13.78 µM 1.65213725416066 0.0696533112879448 no 334 0.0492532869948662 410 16457353
SGTC_3086 9117350 49.47 µM 1.64718473686276 0.0702493666045187 no 335 0.0497600400414272 221 2679265
SGTC_780 0109-0199 192 µM 1.64538311394994 0.0704671695720078 no 336 0.049945414795252 382 610414
SGTC_2043 5101342 149 µM 1.64047656670223 0.0710629672199099 no 337 0.0504530584357658 364 678451
SGTC_1300 1094-0077 113 µM 1.633715554698 0.0718902793739498 no 338 0.0511592953638297 321 5532636
SGTC_3260 9137109 49.47 µM 1.62329277498727 0.073180107023927 no 339 0.052263416652416 252 17478346
SGTC_2634 4'-methoxyflavone 100 µM 1.62166182763284 0.0733835303107095 no 340 0.0524378881996236 356 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_849 0386-0493 241 µM 1.6206396285597 0.0735112465161037 no 341 0.0525474740469215 335 726119
SGTC_2307 7538926 6.34 µM 1.61908126646319 0.073706279310911 no 342 0.0527148894733566 389 96582
SGTC_2674 ligustilide 100 µM 1.61856075922118 0.0737715101006086 no 343 0.0527709019549112 315 5319022 A signalling regulator.
SGTC_715 0868-0130 184 µM 1.60969271879287 0.0748896583114247 no 344 0.0537324776539882 317 2876258
SGTC_2484 5809818 12.04 µM 1.60112634063516 0.0759820023252856 no 345 0.054674469590131 357 2870548
SGTC_1735 st034310 56.75 µM 1.59607153178325 0.0766322347712819 no 346 0.0552364118816481 367 871153
SGTC_2592 piperlongumine 83.33 µM 1.59348541641387 0.0769665355844694 no 347 0.05552566868242 349 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1411 3909-8223 150 µM 1.59342484262256 0.0769743790752535 no 348 0.0555324581610599 380 X1411
SGTC_2075 5212009 200 µM 1.59027883682808 0.0773825802058879 no 349 0.0558859834017601 316 780898
SGTC_626 0214-0009 33 µM 1.58990240700692 0.0774315327296014 no 350 0.0559284025137322 372 3437874
SGTC_1192 1488-0095 21.4 µM 1.58820296576632 0.077652828058063 no 351 0.0561202253511518 363 915875
SGTC_2243 6634756 200 µM 1.58620525501693 0.0779135765723472 no 352 0.0563463780554972 310 885676
SGTC_1999 st074831 12.5 µM 1.58045019360774 0.0786684622795469 no 353 0.0570019022396868 402 17112523
SGTC_1573 oleylamine 1.06 µM 1.57985456533558 0.0787469056830498 no 354 0.0570700881183578 398 5356789 An amine of the fatty acid oleic acid.
SGTC_2299 7976368 114.88 µM 1.57208422614931 0.0797756854162907 no 355 0.0579655095913061 359 2979718
SGTC_1468 k284-1086 134 µM 1.56949098635452 0.0801212789288608 no 356 0.0582667890550525 468 15996457
SGTC_3255 9139072 49.47 µM 1.56787810641655 0.0803367928599306 no 357 0.0584547910667807 372 17646060
SGTC_2708 st078559 56 µM 1.56596117573338 0.0805935035882914 no 358 0.0586788532668499 278 17250902
SGTC_130 0136-0219 337.655 µM 1.56283212403992 0.0810138690469728 no 359 0.0590460430675356 384 234244
SGTC_804 1595-0054 20.9 µM 1.56280423911473 0.081017622610257 no 360 0.0590493234084674 371 761523 Stimulates phospholipase C.
SGTC_569 4130-2812 160 µM 1.5615241517908 0.0811900753036332 no 361 0.0592000649394436 278 743552
SGTC_2092 5303694 80.6725 µM 1.56147040464924 0.0811973221444952 no 362 0.0592064007330379 413 1963699
SGTC_188 3229-0966 278.469 µM 1.56092922436208 0.0812703178279153 no 363 0.0592702255136161 462 5722370
SGTC_2996 9066192 71.4286 µM 1.56021474798136 0.0813667639116661 no 364 0.0593545708041547 410 6472854
SGTC_319 1348-1596 45.5 µM 1.55577553677511 0.0819679418400873 no 365 0.0598807386131451 409 5380505
SGTC_323 4013-0906 34.3 µM 1.55282813417208 0.082368937245262 no 366 0.0602320997130682 361 2910086
SGTC_3235 9132602 49.47 µM 1.55172176925331 0.0825198393769817 no 367 0.0603644057695052 431 4912240
SGTC_187 1488-2104 32.728 µM 1.54794756930766 0.0830361856791318 no 368 0.0608174601901539 407 2852859
SGTC_1452 4194-0072 190 µM 1.54489971397615 0.0834549316877856 no 369 0.0611852613324461 429 1343545
SGTC_991 3996-0057 64.7 µM 1.53965817028727 0.0841787779795395 no 370 0.0618218490420375 390 715343
SGTC_585 0kpi-0023 191 µM 1.53768825089696 0.0844520347442817 no 371 0.0620624288714948 361 64601
SGTC_666 0272-0154 136 µM 1.53750332144583 0.0844777213075016 no 372 0.0620850511563282 440 6870312
SGTC_876 0720-0963 56.8 µM 1.53743259166189 0.084487547171337 no 373 0.0620937051798915 431 765861
SGTC_2291 7917025 104.35 µM 1.53735030316623 0.0844989798638573 no 374 0.062103774634532 430 2964612
SGTC_313 3474-0040 5.03 µM 1.53695672756018 0.0845536770564323 no 375 0.0621519531988026 476 1043375 YIL048W NEO1
SGTC_119 0121-0043 24.815 µM 1.53478246899838 0.0848563234947779 no 376 0.0624186352201206 603 1092378
SGTC_3234 9132280 49.47 µM 1.53288983110472 0.0851204302434765 no 377 0.0626515009095083 423 17612295
SGTC_623 k072-0108 16.9 µM 1.53269795086323 0.0851472403832617 no 378 0.0626751471549668 416 5382803
SGTC_868 0527-0199 213 µM 1.53064513163298 0.0854344631440172 no 379 0.0629285605707601 414 2849450
SGTC_1141 3253-0389 52.6 µM 1.53041256392938 0.0854670488531205 no 380 0.0629573205144185 369 5402031
SGTC_748 act1.228 77.9 µM 1.52255155425121 0.0865739589804007 no 381 0.0639354690039048 479 4421505 YNR035C ARC35
SGTC_776 4476-4378 112 µM 1.51979710131478 0.0869643386024152 no 382 0.0642809889404915 376 2892008
SGTC_1312 1218-2183 165 µM 1.51775652263298 0.087254389994356 no 383 0.064537894592675 417 6744073
SGTC_1299 1079-1439 3.74 µM 1.51572441179336 0.0875439549457267 no 384 0.064794526097444 395 323161
SGTC_3247 9135149 49.47 µM 1.51274500094854 0.0879698007048015 no 385 0.0651722220179926 345 8934436 YOR116C RPO31
SGTC_2155 5570423 76 µM 1.51132072183602 0.0881739171147802 no 386 0.0653533784579815 401 797402
SGTC_828 2074-0507 139 µM 1.50867338338776 0.0885542503320547 no 387 0.0656911353378304 442 X828
SGTC_2771 fluoxetine 41.05 µM 1.4987207259667 0.0899950476594269 no 388 0.0669730487930678 382 3386 A selective serotonin reuptake inhibitor.
SGTC_2256 7954252 200 µM 1.49678643758896 0.090277075505322 no 389 0.0672244181852147 328 2972920
SGTC_3188 9110789 49.47 µM 1.49469542754299 0.090582691854402 no 390 0.0674969740842996 428 849217
SGTC_2638 epoxomicin 18 µM 1.49214059813007 0.0909571403981351 no 391 0.067831145424244 447 9915668 A protesome inhibitor.
SGTC_1396 3511-0007 98.6 µM 1.49208536945924 0.0909652476482723 no 392 0.06783838341108 374 X1396
SGTC_1501 4491-0275 38.4 µM 1.49159988453765 0.0910365371013659 no 393 0.067902034249465 409 5104718
SGTC_754 3474-0146 171 µM 1.48990885967812 0.0912851737037093 no 394 0.0681241008553388 397 24762078
SGTC_2444 5485484 36.41 µM 1.48951171813599 0.0913436395874644 no 395 0.068176334971557 446 6790631
SGTC_1621 st003705 32.4 µM 1.4865910621646 0.0917744620433537 no 396 0.068561424922686 471 24207032
SGTC_3102 9121669 49.47 µM 1.48376012685152 0.0921934847393887 no 397 0.0689362843261297 363 41905072
SGTC_287 k060-0039 29.6 µM 1.48369788591972 0.0922027132549034 no 398 0.0689445436971387 401 5861974
SGTC_672 1441-0018 53.7 µM 1.48196028163299 0.0924606253982415 no 399 0.0691754317950524 400 251141
SGTC_2461 5755302 26.15 µM 1.48044674776692 0.092685713474785 no 400 0.0693770311142075 470 2788904
SGTC_619 1652-1634 108 µM 1.47954063208962 0.0928206619959588 no 401 0.0694979400690971 388 5400454
SGTC_1613 st002381 52.1 µM 1.47770751598473 0.093094113590529 no 402 0.0697430408910387 431 551167
SGTC_1326 1431-2094 10.8 µM 1.47556359045675 0.0934146844349205 no 403 0.0700305427139736 459 616278
SGTC_1207 2099-0101 141 µM 1.47501560081871 0.0934967533763603 no 404 0.0701041745998617 481 5837381
SGTC_679 0422-0091 41.4 µM 1.46206849146458 0.0954512804758429 no 405 0.0718612210072989 480 627384 YHR062C RPP1
SGTC_54 0159-0055 9 µM 1.45191757365736 0.0970045961444902 no 406 0.0732622627541072 455 3319099
SGTC_509 pifithrin 175 µM 1.45103109007296 0.0971411237165417 no 407 0.073385601579111 405 4817 A p53 inhibitor.
SGTC_160 3453-0671 289.699 µM 1.44743144011406 0.0976969557469538 no 408 0.0738880627258602 464 5322268
SGTC_2821 7996764 71.43 µM 1.44467604002307 0.0981239977889608 no 409 0.074274451495176 485 2987135
SGTC_456 gingerol 170 µM 1.44389053338618 0.0982459886308057 no 410 0.0743848849692964 443 442793 A herb.
SGTC_1859 st055998 20 µM 1.44371667640949 0.0982730039953148 no 411 0.074409344257552 474 676301
SGTC_3185 9108267 49.47 µM 1.44307531948428 0.0983727105062306 no 412 0.0744996274767711 471 4910486
SGTC_1977 st070720 65.3 µM 1.44221949656831 0.0985058736438515 no 413 0.0746202310857118 410 682188
SGTC_3268 9137683 49.47 µM 1.43978106466018 0.0988860089797435 no 414 0.0749646750021499 381 1953228
SGTC_3351 9150312 21.596 µM 1.43947496598287 0.0989338034500709 no 415 0.0750079989081637 475 4904905
SGTC_1722 st034304 3.6505 µM 1.43892107003558 0.0990203321225514 no 416 0.0750864435252758 475 4036148 YLR033W RSC58
SGTC_2077 5212015 200 µM 1.43765246937817 0.0992187192967652 no 417 0.0752663427533185 454 780900
SGTC_445 e6 berbamine 66 µM 1.43637972103726 0.0994180470092364 no 418 0.0754471601744202 603 6610268 A calcium/calmodulin antagonist.
SGTC_762 1165-0429 115 µM 1.43033945606586 0.100368016955556 no 419 0.0763098078689063 456 5967793
SGTC_1659 st012954 42.1 µM 1.42049304089488 0.101930763214151 no 420 0.0777320965780652 446 24207262
SGTC_3008 9078912 71.4286 µM 1.41935630424197 0.102112311152117 no 421 0.0778975823688452 428 16648731
SGTC_1619 st003326 88.7 µM 1.41762481251303 0.102389299184092 no 422 0.0781501660105498 424 2849032
SGTC_987 1497-1013 404 µM 1.41748407599396 0.102411836897125 no 423 0.0781707234038919 412 1676435
SGTC_2138 5575593 77.673 µM 1.41659937573069 0.10255359646457 no 424 0.0783000455793909 386 762213
SGTC_1395 3486-0190 4.35 µM 1.41581893887013 0.102678767808429 no 425 0.0784142615510382 495 6748079
SGTC_1212 0520-0165 585 µM 1.41508903261877 0.102795935192907 no 426 0.0785211967035335 478 5403258
SGTC_1216 1165-0504 9.65 µM 1.41015304356915 0.103590830087603 no 427 0.0792472487676169 488 6304004
SGTC_387 norethindrone acetate 66.7 µM 1.40897544604305 0.10378112842765 no 428 0.0794212143523692 421 541197
SGTC_2223 6903751 107.57 µM 1.40831518870329 0.103887936105797 no 429 0.079518880044034 395 5598863
SGTC_2017 5132927 60.65 µM 1.40401499298899 0.10458551568242 no 430 0.0801571924985202 487 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3266 9136860 49.47 µM 1.40399524249245 0.104588727425225 no 431 0.0801601331316644 496 4871271 YPR165W RHO1
SGTC_1175 0741-0056 27.6 µM 1.39972288589791 0.105285160394952 no 432 0.0807981588750121 548 765927
SGTC_1831 st055328 12 µM 1.3981245331412 0.105546566936744 no 433 0.0810378369447931 474 1103068
SGTC_1132 3456-3614 2.5 µM 1.39459542750712 0.106125404760485 no 434 0.0815689373650625 591 3125502
SGTC_2115 tiliquinol 12.7705 µM 1.39290977209189 0.106402690932192 no 435 0.0818235385044402 444 71208 A bioactive hydroxyquinoline.
SGTC_156 3474-0145 5.642 µM 1.38975181313752 0.106923574761918 no 436 0.0823021275878509 480 2265471
SGTC_532 1548-0774 215 µM 1.38692641897793 0.107391161286944 no 437 0.0827321004881202 508 5932993
SGTC_2515 chrysin 20.77 µM 1.38514845650312 0.107686158449177 no 438 0.0830035388293021 484 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2651 TUB2.036 5 µM 1.3800642605698 0.108532942009018 no 439 0.0837834300490257 692 15992207 YFL037W TUB2
SGTC_2847 9005661 71.43 µM 1.37397706748668 0.109553064513699 no 440 0.0847244009771115 338 2991449
SGTC_3061 glucosamine 200 µM 1.3715985627216 0.109953531300331 no 441 0.0850942207556406 461 91431 and experimental redox chemotherapeutic
SGTC_1877 wortmannin 25 µM 1.37044082902718 0.110148837560653 no 442 0.0852746671363931 554 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2652 actinonin 100 µM 1.36862166989372 0.110456226849895 no 443 0.0855587833407195 444 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2397 5161689 200 µM 1.36666265669251 0.110787934950235 no 444 0.0858655339958325 530 2259942
SGTC_951 1171-0579 82.7 µM 1.36598985214156 0.110902021453167 no 445 0.085971074271423 593 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2170 morpholine 200 µM 1.36581008812195 0.110932518022657 no 446 0.0859992895914106 478 121171 Reacts with secondary amines.
SGTC_738 1315-0003 72.4 µM 1.36575930490011 0.110941134372378 no 447 0.0860072616565199 528 6251474
SGTC_46 0329-0187a 2.197 µM 1.36434540138356 0.111181222790265 no 448 0.0862294415056299 610 46494817
SGTC_2303 7774051 200 µM 1.36414963427865 0.111214494395845 no 449 0.0862602380206754 472 2953184
SGTC_2621 lithochol-11-enic acid 100 µM 1.36368652655693 0.111293230262812 no 450 0.0863331231693785 548 6708711
SGTC_2922 7999257 32.47 µM 1.36219441215015 0.111547185439405 no 451 0.0865682694151045 443 2988377
SGTC_1756 st041558 35.5 µM 1.35829599551917 0.112212645111274 no 452 0.087184890219607 551 3955792
SGTC_1422 4031-0024 15.5 µM 1.3551290763064 0.112755323162285 no 453 0.0876882181479506 495 782427
SGTC_1490 4089-0339 670 nM 1.35488463792116 0.112797287488394 no 454 0.087727157406211 462 742542
SGTC_3151 9099821 49.47 µM 1.35430358096435 0.112897086066778 no 455 0.0878197720863861 461 17174189
SGTC_757 1066-0008 322 µM 1.34930372896389 0.113758433546275 no 456 0.0886197141934441 545 6842497
SGTC_1181 1222-0449 220 µM 1.34837206038003 0.113919452725083 no 457 0.0887693728111093 502 658318
SGTC_638 3970-0837 4.09 µM 1.34774132535391 0.114028554060053 no 458 0.0888707977396146 518 4118451 YLR208W SEC13
SGTC_3202 9113761 49.47 µM 1.34584498533817 0.114357021579142 no 459 0.0891762570828428 588 4798415
SGTC_903 1134-0042 114 µM 1.34406334757294 0.114666234635151 no 460 0.0894639515479441 502 701009
SGTC_603 3794-0023 45.9 µM 1.34372436441461 0.114725134336968 no 461 0.0895187677905662 479 3802260
SGTC_2982 9019404 25.97 µM 1.3380068839035 0.115721814791136 no 462 0.0904470963858352 440 22333232
SGTC_2146 5545642 200 µM 1.33730210828269 0.115845096887025 no 463 0.0905620215524514 511 825326
SGTC_1932 st074806 40.9 µM 1.33181479674896 0.116808149310499 no 464 0.0914605272319119 573 17251235
SGTC_1747 st037496 66.6 µM 1.33073275361582 0.116998721635526 no 465 0.0916384808413362 560 723305
SGTC_717 1532-0246 73.2 µM 1.33027581920075 0.117079264276025 no 466 0.0917137056075091 548 9561992
SGTC_2383 9036125 200 µM 1.32318804547031 0.118333641139529 no 467 0.0928864252566485 478 79580
SGTC_2409 alverine citrate 63.97 µM 1.3228393909716 0.118395589404015 no 468 0.0929443972649238 540 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3214 9129694 49.47 µM 1.32246897200803 0.118461429848662 no 469 0.0930060174272938 488 17158655
SGTC_2133 5320837 200 µM 1.32128218466602 0.118672550674727 no 470 0.0932036459678834 487 2841355
SGTC_1594 piperine 70.1 µM 1.31565479865469 0.119677240132471 no 471 0.0941449659967594 541 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_268 camptothecin 39.6153 µM 1.31350720916239 0.120062238613986 no 472 0.094506046640979 643 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.3085468362242 0.120954819092486 no 473 0.0953439497588299 563 5393153
SGTC_182 3448-4371 550.524 µM 1.30113663926457 0.122296906829761 no 474 0.0966058441958572 577 3491403
SGTC_2111 5486399 200 µM 1.30092168381941 0.122335993585834 no 475 0.0966426315372969 601 689674
SGTC_2426 5582046 32.21 µM 1.29989523730488 0.122522759976958 no 476 0.0968184388437211 561 2251934
SGTC_2116 5511452 16.8835 µM 1.29761161911347 0.12293899162885 no 477 0.0972104137301645 550 870744
SGTC_2404 5161160 200 µM 1.29613111769658 0.123209369541777 no 478 0.0974651579444636 572 2831543
SGTC_938 3126-1755 342 µM 1.29522164232131 0.123375669782438 no 479 0.0976218904822929 580 1777771
SGTC_927 2425-1185 123 µM 1.29478855004217 0.123454917223514 no 480 0.0976965914609797 520 730375
SGTC_2219 9098279 200 µM 1.29117010757488 0.124118415183818 no 481 0.0983223490233348 517 902349
SGTC_1524 corynanthine 62.1 µM 1.29112029159066 0.124127567099511 no 482 0.0983309844179019 517 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1114 scopoletin 1.73284 µM 1.29044948739998 0.124250849500051 no 483 0.0984473196483563 530 5280460 A coumarin with genotoxic properties.
SGTC_1405 3909-7894 12 µM 1.2898981292303 0.124352243861459 no 484 0.0985430152063154 556 7104060
SGTC_806 3966-4455 5.86 µM 1.28854646371284 0.124601058924635 no 485 0.098777902848161 490 714982
SGTC_1222 0366-0074 1.18 µM 1.28776699115253 0.124744702616184 no 486 0.098913542953314 578 286520
SGTC_2369 9071472 200 µM 1.28654322560763 0.124970455435785 no 487 0.0991267716467235 555 17296037
SGTC_179 1273-0063 6.77 µM 1.28620387121208 0.125033107981825 no 488 0.0991859601897276 503 3108139
SGTC_674 0498-0004 451 µM 1.28435313760167 0.125375181619368 no 489 0.0995092110013699 549 4231473
SGTC_277 nystatin 15.5 µM 1.28312635396976 0.125602289449161 no 490 0.0997239060687239 581 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.28154624536714 0.125895229171245 no 491 0.100000933685453 662 368090
SGTC_1561 5-methoxyflavone 52.9 µM 1.27964984904392 0.126247434801666 no 492 0.100334154899421 476 94525
SGTC_3010 9080089 71.4286 µM 1.27722288699676 0.126699180018733 no 493 0.100761784506465 560 17027233
SGTC_2718 lomofungin 53.02 µM 1.27561842339129 0.126998445957181 no 494 0.101045219123066 543 5351222 A RNA synthesis inhibitor.
SGTC_3132 9126706 49.47 µM 1.27263515737122 0.127556194335449 no 495 0.101573768441242 524 850858
SGTC_1374 2889-5571 141 µM 1.27261855003372 0.127559303985769 no 496 0.101576716410447 601 2853281
SGTC_875 0709-0210 25.7 µM 1.27179276078467 0.127713995837564 no 497 0.10172338088092 615 6251364
SGTC_1265 0819-1001 68.8 µM 1.27010387287137 0.128030774493135 no 498 0.102023816137889 534 3106768
SGTC_1623 st003709 20.3 µM 1.26796642737449 0.128432469468981 no 499 0.102404970018166 645 16192618
SGTC_3179 9107801 49.47 µM 1.25788987388366 0.130337958860268 no 500 0.104215793158828 567 4818259
SGTC_1056 3448-1962 115 µM 1.25722873742842 0.130463660737627 no 501 0.104335410046151 554 715507
SGTC_1802 st050112 57.9 µM 1.25693022551652 0.130520444274828 no 502 0.104389451255708 582 4662563
SGTC_936 3005-4620 401 µM 1.25581642176386 0.130732465111193 no 503 0.104591268140009 641 777207
SGTC_2723 salbutamol 83.58 µM 1.25276937842302 0.131313708623619 no 504 0.105144824378348 473 9884233 β2-adrenoceptor agonist
SGTC_2199 6590217 200 µM 1.25270508701654 0.131325991824383 no 505 0.1051565269914 504 703109
SGTC_986 1493-0483 84 µM 1.25053283663584 0.131741477651675 no 506 0.105552483950561 569 40079
SGTC_415 dibenzyl ketone 100 µM 1.24691043114523 0.1324363498759 no 507 0.106215170761856 607 7593
SGTC_1275 0867-0008 21.1 µM 1.24555188659586 0.132697604368669 no 508 0.106464477664948 581 3422836
SGTC_2218 6965428 192.983 µM 1.24205641156905 0.133371431509263 no 509 0.107107874648309 596 675684
SGTC_1562 morin hydrate 59.1 µM 1.24104605635964 0.133566636711933 no 510 0.107294367702797 565 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2497 7-hydroxyflavone 100 µM 1.23997303741565 0.133774163865235 no 511 0.10749268354498 523 5281894
SGTC_1751 st044839 27.194 µM 1.23669570891708 0.134409387241338 no 512 0.108100036188099 569 5291326
SGTC_2220 6782180 200 µM 1.23154419873993 0.135412051613216 no 513 0.109059698250249 506 833803
SGTC_2565 isoliquiritigenin 100 µM 1.22764673556094 0.136174032485559 no 514 0.109789804767778 486 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_147 4466-0538 29.23 µM 1.22645091926954 0.136408409959878 no 515 0.110014517177292 621 6742687 YHR072W ERG7
SGTC_1990 st072050 59.8 µM 1.22509763595413 0.136673983319027 no 516 0.110269217900008 614 17233948
SGTC_1279 0874-0590 65.2 µM 1.22475841612427 0.13674060845927 no 517 0.110333128516993 615 3523074
SGTC_1091 telmisartan 47.6 µM 1.22444243872523 0.136802688594819 no 518 0.110392684041029 601 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2826 7992541 19.48 µM 1.22344707897031 0.136998373023905 no 519 0.110580440433067 585 2985066
SGTC_2716 st080858 38.6235 µM 1.22089636851136 0.137500707027115 no 520 0.111062629817277 605 5296050
SGTC_1145 3546-0597 10.2 µM 1.21807159268786 0.138058480848115 no 521 0.111598383937665 629 875334
SGTC_1963 st076565 50.3 µM 1.21788311859928 0.138095751348444 no 522 0.111634196100669 597 4914280
SGTC_1466 k213-0079 57.5 µM 1.21603059945697 0.138462449702929 no 523 0.111986632869709 614 3657981
SGTC_1931 st074438 57.1 µM 1.21541325753954 0.138584797209372 no 524 0.112104257046847 577 2787313
SGTC_1324 1418-0026 34.4 µM 1.21135879589742 0.139390158231699 no 525 0.112878961928643 632 1372513
SGTC_1 0258-0098 57.368 µM 1.20696286993038 0.1402669370894 no 526 0.113723221801401 533 6790032 YDR047W HEM12
SGTC_1813 st051246 8.6015 µM 1.20602920354471 0.140453640495957 no 527 0.113903115178449 573 5291959
SGTC_912 3474-0017 2.18 µM 1.20338393536462 0.140983525383147 no 528 0.114413890786017 636 3360550
SGTC_2978 9011784 42.97 µM 1.1995238295395 0.141759189679798 no 529 0.11516216230412 726 2994934
SGTC_3264 9137442 49.47 µM 1.19911405122516 0.141841701463769 no 530 0.115241800579695 587 17015726
SGTC_2048 5246248 200 µM 1.19874030058724 0.141916987172006 no 531 0.115314471195187 577 677046
SGTC_543 3844-1095 191 µM 1.19859150610625 0.14194696681745 no 532 0.115343411276326 669 4230703
SGTC_1726 st035556 14.5795 µM 1.19692884166763 0.142282258058663 no 533 0.115667145692948 676 5919439
SGTC_198 3454-2873 16.191 µM 1.19668804156806 0.142330861953031 no 534 0.11571408490349 624 710957
SGTC_353 1988-1175 58.3 µM 1.19581869203857 0.14250642783221 no 535 0.115883659967842 577 2788357
SGTC_2036 5160441 105 µM 1.19418680116803 0.142836384959656 no 536 0.116202452460168 701 134534 YIL048W NEO1
SGTC_1140 3229-1848 2.98 µM 1.19414305833638 0.14284523656036 no 537 0.116211006248618 624 2849525
SGTC_2864 9034755 47.6 µM 1.19176190516763 0.143327635340241 no 538 0.116677308451933 618 4930451
SGTC_1399 3562-5772 25 µM 1.18830050659503 0.144030841334875 no 539 0.117357519107086 538 23847490
SGTC_1045 1348-1485 165 µM 1.18778267313956 0.144136242362971 no 540 0.117459521241409 678 6810614
SGTC_2834 9001755 58.44 µM 1.18458903981209 0.14478743119026 no 541 0.118089986289404 567 2989575
SGTC_1008 4106-0037 6 µM 1.1828851618079 0.145135664896777 no 542 0.118427331531918 600 2905394
SGTC_282 k297-0036 65.7 µM 1.18225205281259 0.145265201411372 no 543 0.118552852122532 591 5061378
SGTC_713 1488-1073 324 µM 1.18063446539151 0.145596519143719 no 544 0.118873982915432 631 3312542
SGTC_756 0508-1999 28.3 µM 1.17833051928825 0.14606929493633 no 545 0.119332432673742 619 6753853
SGTC_1604 st002052 72.4 µM 1.17295275384177 0.147176835746044 no 546 0.12040737632399 645 6254834 YHR062C RPP1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.17237094463708 0.147296994862826 no 547 0.120524079777598 625 4330530
SGTC_2605 digitonin 300 nM 1.16773693798467 0.148256387835772 no 548 0.121456446134962 738 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_59 0330-0160 1.33 µM 1.16683660693508 0.148443270128196 no 549 0.121638180266447 786 4293482
SGTC_1150 3909-7983 10.9 µM 1.16320473713352 0.149198738674269 no 550 0.1223732225098 670 23965914
SGTC_60 0986-0278 202 µM 1.16299409855147 0.149242632432216 no 551 0.12241594840251 506 3110598
SGTC_1078 idebenone 36.1 µM 1.16204447298084 0.149440626480103 no 552 0.12260870027092 701 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1597 7-benzyloxygramine 47.5 µM 1.1573334186068 0.150425458529428 no 553 0.123568082514241 766 260807
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.15641978340264 0.150616950739147 no 554 0.12375474668335 604 5282362
SGTC_2118 5526350 200 µM 1.15358458562483 0.151212223612243 no 555 0.124335260459384 669 743594
SGTC_2812 7970281 58.44 µM 1.15273615505273 0.15139066235587 no 556 0.124509348354127 660 2233435
SGTC_2683 piperine 63.03 µM 1.15102794557845 0.151750351196794 no 557 0.124860369472325 640 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1143 3454-2408 5.08 µM 1.15027150350554 0.151909812571226 no 558 0.125016031946794 617 X1143
SGTC_943 3253-1379 105 µM 1.14972584474831 0.152024908966645 no 559 0.12512840304704 657 668464
SGTC_3200 9114385 49.47 µM 1.1490162401345 0.152174673256001 no 560 0.125274642082178 612 17018030 YLR208W SEC13
SGTC_988 1497-1057 103 µM 1.14868732868622 0.152244124269623 no 561 0.125342466333313 675 3533044
SGTC_2649 anisomycin 9.56 µM 1.14515447393789 0.152991427957223 no 562 0.126072586686235 632 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1494 4358-1428 177 µM 1.14110539010054 0.153850915328913 no 563 0.126913034261065 697 1564571
SGTC_1996 st072960 66.8 µM 1.13720113707717 0.154682680459489 no 564 0.127727105869862 714 1719405
SGTC_799 1310-0557 151 µM 1.13693921648356 0.154738586385886 no 565 0.127781848270295 670 5354492
SGTC_3097 9117246 49.47 µM 1.13269776712339 0.155645765528014 no 566 0.128670597840842 664 16423892
SGTC_552 k242-0005 476 µM 1.13157497476057 0.155886499123975 no 567 0.128906583053054 667 4088318
SGTC_2491 paeonol 100 µM 1.13083333869631 0.156045645004082 no 568 0.129062622477248 650 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2989 9073649 71.4286 µM 1.12913261641412 0.156411003042004 no 569 0.129420946993963 772 21367202
SGTC_1060 3448-7350 82 µM 1.12876631026325 0.156489768517632 no 570 0.129498214034772 693 570178
SGTC_1749 st037932 54.2 µM 1.12607865084739 0.157068484824482 no 571 0.130066114866678 640 594497
SGTC_1478 0453-0656 35.7 µM 1.12330899812505 0.157666327051465 no 572 0.130653141782744 678 5258496
SGTC_1940 st075990 51.1 µM 1.12091677205772 0.158183901661654 no 573 0.131161645479557 753 1084979
SGTC_3292 9120825 59.784 µM 1.12054349402171 0.158264763396829 no 574 0.131241114478846 699 24824900
SGTC_2656 pseudo-anisatin 100 µM 1.11815726832337 0.158782322768185 no 575 0.131749915530951 679 6708809 A neurotoxin.
SGTC_3162 9099653 49.47 µM 1.1178921229325 0.15883989977294 no 576 0.13180653484575 634 25237511
SGTC_1970 st070122 35.8 µM 1.11644715011322 0.159153919814809 no 577 0.132115390268596 679 102928
SGTC_1515 3460-0031 42.1 µM 1.11376773438721 0.159737283161453 no 578 0.132689421194526 604 2876596
SGTC_2224 6650123 117.647 µM 1.11177561251154 0.160171914265248 no 579 0.13311731999769 651 2908370
SGTC_886 0866-0150 153 µM 1.11171764560349 0.160184572757127 no 580 0.133129785231573 742 271463
SGTC_1933 st074711 15.9 µM 1.1106096213426 0.160426662669582 no 581 0.133368209787231 723 17250958
SGTC_129 0088-0017 176.636 µM 1.10824624525521 0.160943830130871 no 582 0.133877741845739 669 182446
SGTC_2797 7859098 81.82 µM 1.1075802659072 0.161089759853021 no 583 0.134021564970038 693 972681
SGTC_691 1548-0686 185 µM 1.10345365121888 0.16199591006429 no 584 0.134915104355284 719 46495133
SGTC_80 0159-0065 512.242 µM 1.10168996020571 0.162384204168807 no 585 0.135298241597589 601 1548079
SGTC_317 4495-0002 170 µM 1.10091162245003 0.162555755459943 no 586 0.135467561581209 645 15991618
SGTC_1028 k015-0029 4.8 µM 1.10004291701626 0.162747363644653 no 587 0.135656711601649 707 4588309
SGTC_2561 acetosyringone 100 µM 1.09918151735394 0.162937505401731 no 588 0.135844449445067 815 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1833 st055984 71 µM 1.09836191018251 0.163118556094476 no 589 0.136023243926779 697 676288
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.09780566215598 0.163241505374549 no 590 0.136144679244232 711 5282309
SGTC_1403 3909-7815 62.9 µM 1.0975915596244 0.163288845186618 no 591 0.136191440049925 661 6615483
SGTC_2921 7974240 10.71 µM 1.09702311121003 0.163414577030549 no 592 0.136315644667149 691 2979074 YDR527W RBA50
SGTC_2462 5162487 171.77 µM 1.09576747816952 0.163692526100167 no 593 0.136590272074907 731 2259986
SGTC_2606 farnesol 9.78 µM 1.09432989632478 0.164011128279765 no 594 0.136905158927676 724 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2403 6032726 181.2 µM 1.0941802324337 0.164044320448801 no 595 0.136937969685624 684 2881040
SGTC_2850 9015429 58.44 µM 1.09333649389859 0.164231524679136 no 596 0.137123042705308 662 6457570
SGTC_96 0929-0093 37.281 µM 1.08809560469906 0.165397446803715 no 597 0.138276451944145 682 6991579
SGTC_1121 fusaric acid 630.51 nM 1.08763625438728 0.165499891480894 no 598 0.138377859586179 724 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1768 st044301 37.178 µM 1.08663415508522 0.165723522881531 no 599 0.13859926210086 743 3931349
SGTC_2636 apigenin dimethyl ether 100 µM 1.0849195003621 0.166106623161464 no 600 0.138978655189434 720 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1041 0206-0046 107 µM 1.08404064680135 0.166303204444806 no 601 0.139173388550504 712 50494
SGTC_2098 5376439 882.5 nM 1.08336754807326 0.166453864204071 no 602 0.139322656976524 754 2844116
SGTC_2960 9079389 5.97 µM 1.08246747150951 0.166655466090839 no 603 0.139522430858465 745 16457355
SGTC_2112 5488546 200 µM 1.08177956797854 0.166809651007282 no 604 0.139675243778088 729 600757
SGTC_1195 1502-0147 41.1 µM 1.07941338320648 0.167340703978302 no 605 0.14020174374597 750 817940
SGTC_376 3970-0862 59.1 µM 1.07593585139609 0.168123156380496 no 606 0.140977973327544 739 3135186
SGTC_301 4119-0100 24.5 µM 1.07585138774661 0.168142190126313 no 607 0.140996862883692 766 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1971 st069429 63.5 µM 1.07378139484398 0.168609092979168 no 608 0.141460335273624 712 1246522 YGL099W LSG1
SGTC_2576 guaiol 23.12 µM 1.07267884504375 0.168858121426774 no 609 0.141707617624789 777 227829
SGTC_1782 st039423 80.636 µM 1.07147009026314 0.169131409368775 no 610 0.141979056138679 675 2068169
SGTC_704 1310-0270 142 µM 1.07100475066532 0.169236693892866 no 611 0.142083646784503 740 5718033
SGTC_2372 9071633 200 µM 1.07094444386933 0.169250341571268 no 612 0.142097205275232 800 21321366
SGTC_3107 9121808 49.47 µM 1.07060080418048 0.169328122143248 no 613 0.142174480867597 679 662681
SGTC_2234 tolnaftate 200 µM 1.06887286607215 0.169719577183797 no 614 0.142563480021407 685 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_845 0330-0138 4.51 µM 1.06863902178646 0.169772597897458 no 615 0.142616179063636 739 9039800
SGTC_172 1112-0046 2.638 µM 1.06815111327899 0.169883258093379 no 616 0.14272617631321 652 2802135 YIL048W NEO1
SGTC_318 1488-0629 67.2 µM 1.06792692488757 0.169934120693951 no 617 0.142776738020935 704 3662576
SGTC_9 0092-0002 10.449 µM 1.06604298041083 0.17036192507714 no 618 0.143202106595106 752 759368
SGTC_1554 st069299 38.7 µM 1.06515912216366 0.170562868328975 no 619 0.14340196424585 720 24207999
SGTC_1296 1068-0102 11.9 µM 1.06198816150933 0.171285027562613 no 620 0.144120529802573 747 767053
SGTC_1769 st044406 64.4 µM 1.0604066974951 0.171645922004081 no 621 0.14447980827465 752 670903
SGTC_2413 inermin 26.06 µM 1.05986021790939 0.171770743003646 no 622 0.144604098200302 769 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1675 st018485 24.5 µM 1.05859475358963 0.172060009276168 no 623 0.144892188631095 737 3323024
SGTC_1794 st048918 76.9 µM 1.05708919780835 0.172404561660659 no 624 0.145235440350614 667 672303
SGTC_1112 tnp00069 1.16933 µM 1.05561147529156 0.172743171965466 no 625 0.145572878017348 799 145826
SGTC_2987 9018338 71.43 µM 1.05535858396062 0.172801162788369 no 626 0.14563067849374 750 5055682
SGTC_1837 st055472 66.5 µM 1.05323663015919 0.173288239383798 no 627 0.146116277072656 759 676091
SGTC_1897 st060201 15 µM 1.05171947157215 0.173637025746579 no 628 0.146464137374307 707 611878
SGTC_2736 butenafine 14.65 µM 1.04880244113331 0.174308888931398 no 629 0.147134526863011 784 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2910 7948405 25.97 µM 1.04591783927467 0.174974905087681 no 630 0.147799483635155 701 2971328
SGTC_3312 9133330 71.43 µM 1.0455990709726 0.175048603392382 no 631 0.14787308919815 811 17617324
SGTC_2993 9054257 71.4286 µM 1.04480953920679 0.175231225619595 no 632 0.148055502594118 753 6470217 YGL055W OLE1
SGTC_1760 st045453 10.4495 µM 1.04021934599093 0.176295349750173 no 633 0.149119002725994 797 3323419 YIL048W NEO1
SGTC_2055 5235184 200 µM 1.03995173117594 0.176357515598694 no 634 0.149181163315669 746 2836034
SGTC_3271 9137798 49.47 µM 1.03681810954888 0.177086475110337 no 635 0.149910317026486 688 6498326
SGTC_1906 st060206 94.7 µM 1.03655904169005 0.177146825907572 no 636 0.149970704995477 818 5133468
SGTC_1167 k781-0610 148 µM 1.03560747521384 0.177368608248742 no 637 0.150192651583689 813 4525169
SGTC_1912 st060209 90.8 µM 1.03358982159067 0.177839444005354 no 638 0.150663979865236 717 688787
SGTC_1138 3761-0006 1.03 µM 1.0312706696555 0.178381609728805 no 639 0.151206954295014 772 12061087
SGTC_3181 9108277 49.47 µM 1.02966173606676 0.178758353501001 no 640 0.151584411820512 749 17097298
SGTC_918 glabranin 770.725 nM 1.02468210067881 0.179927543515069 no 641 0.152756605721316 776 124049 Also referred to as licorice root.
SGTC_1956 st077085 54 µM 1.0229724757557 0.180330058667054 no 642 0.153160429906013 807 24208685
SGTC_207 4185-0010 4.486 µM 1.02295356695515 0.180334513723653 no 643 0.153164900236081 872 3761753
SGTC_2089 5281248 129.67 µM 1.02229435660171 0.180489871845658 no 644 0.15332080171597 785 2737878
SGTC_1172 0370-0043 85 µM 1.02133840027009 0.18071531410042 no 645 0.15354706953704 769 376585
SGTC_1785 bathophenanthroline 24 µM 1.02080981453155 0.180840045729339 no 646 0.153672276781866 754 72812 An iron chelator.
SGTC_443 clozapine 122 µM 1.01923133814993 0.181212843620184 no 647 0.15404657611312 703 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2225 6654152 15.4 µM 1.01670919505723 0.181809510902606 no 648 0.154645895105118 714 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1847 st056231 15 µM 1.0155204131492 0.182091168509658 no 649 0.154928910494702 831 5393180
SGTC_3295 9122362 53.5725 µM 1.0145816592454 0.182313779734122 no 650 0.155152642857026 737 4730473
SGTC_2289 7946404 165.07 µM 1.01405691202203 0.182438289630217 no 651 0.155277798277388 835 1246120 YPR165W RHO1
SGTC_701 4424-0219 185 µM 1.01030896927638 0.183329130251481 no 652 0.156173642640266 870 2911779
SGTC_1093 fluphenazine 7.97 µM 1.00874446167993 0.183701795813805 no 653 0.156548601305078 807 6602611 An atypical antipsychotic.
SGTC_1471 k673-0312 37 µM 1.00708587844541 0.184097385185541 no 654 0.156946753374924 791 24099884
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.00553074236642 0.184468782665478 no 655 0.157320677009769 793 390807
SGTC_2572 astragaloside iv 100 µM 1.00440284169641 0.184738439188319 no 656 0.157592240431726 778 45006101 An anti-inflammatory agent.
SGTC_2876 9059903 25.97 µM 1.0036193341508 0.184925902965429 no 657 0.157781065878648 844 6916095
SGTC_3083 9117465 49.47 µM 1.00099940631914 0.185553610873708 no 658 0.158413547702058 786 16420915
SGTC_2200 6600604 21.907 µM 1.00097360415366 0.185559799376518 no 659 0.158419784911619 815 2904777
SGTC_2728 chlorpromazine 9.18 µM 0.997838816232454 0.186312613319673 no 660 0.159178762221249 700 2726 A thorazine and dopamine antagonist.
SGTC_1627 st003713 25.6 µM 0.997644988216164 0.186359222820571 no 661 0.159225768832981 862 16195070 YER133W GLC7
SGTC_1780 st038448 24.544 µM 0.995771222803895 0.186810176452012 no 662 0.15968065773456 803 728868 YDL195W SEC31
SGTC_1090 efavirenz 20.7 µM 0.994727695007832 0.18706161177421 no 663 0.159934360429004 806 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_895 0964-0006 13.7 µM 0.994662012848675 0.187077444720194 no 664 0.159950337903385 799 6738897
SGTC_2314 7727897 200 µM 0.994230656386772 0.187181445509504 no 665 0.160055293200375 791 900724
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.992967908363505 0.187486101724588 no 666 0.160362796954253 821 229346 A bile salt which induces apoptosis.
SGTC_2181 6316240 54.2555 µM 0.991502659606216 0.187839998029832 no 667 0.160720097160853 746 12779990
SGTC_3066 9117245 49.47 µM 0.989442831001843 0.188338198140714 no 668 0.161223263792263 835 17176980
SGTC_2217 6934799 96.0675 µM 0.98763152929703 0.188776961196622 no 669 0.161666569503496 829 675606
SGTC_1845 st056753 3.01 µM 0.986764151784841 0.188987294413186 no 670 0.161879136237906 810 5375839
SGTC_2731 amoxapine 43.43 µM 0.986602313899908 0.18902655498742 no 671 0.161918817722254 749 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3301 9125354 19.7965 µM 0.985147405075274 0.189379729764707 no 672 0.16227583542183 738 41905162
SGTC_774 k060-0086 136 µM 0.984679404809505 0.189493421712623 no 673 0.162390786096761 902 5911235
SGTC_3324 9138759 60.749 µM 0.982325156076555 0.190065979399967 no 674 0.162969842586779 808 45595710
SGTC_81 0411-0046 9.971 µM 0.980493247445913 0.190512237719288 no 675 0.163421350600083 751 12925265
SGTC_3100 9120536 49.47 µM 0.978384614232108 0.191026702649807 no 676 0.163942067439832 713 16421196
SGTC_955 1216-0110 33 µM 0.977161158175134 0.191325592029195 no 677 0.164244687024921 809 3619719
SGTC_1929 genistein trimethyl ether 50.5 µM 0.976122718643122 0.191579506767341 no 678 0.164501827142814 839 136420
SGTC_2879 9041815 71.43 µM 0.975920068752664 0.191629081902279 no 679 0.164552038056078 738 4942971
SGTC_1446 4239-0190 62 µM 0.975203822993244 0.191804363210236 no 680 0.164729583084523 855 1340085
SGTC_219 mitoxanthrone 164.414 µM 0.974798137054097 0.191903687137159 no 681 0.164830200697566 773 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_210 3551-0445 56.827 µM 0.973175823338004 0.192301192154554 no 682 0.165232962276558 827 2865180 YOR207C RET1
SGTC_1104 tacrolimus 29.8 µM 0.972789873949725 0.192395832931608 no 683 0.165328873201641 858 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1853 st056710 91.2 µM 0.971166543681412 0.192794210425086 no 684 0.165732675614331 878 269167
SGTC_384 k007-0144 5.16 µM 0.970919175650284 0.19285496062357 no 685 0.165794264201568 857 6824886
SGTC_2421 5690543 90.72 µM 0.970777687350062 0.192889713467472 no 686 0.165829497977215 824 3397993
SGTC_2750 bromebric acid 70.15 µM 0.970623864174639 0.192927500385589 no 687 0.165867808905906 884 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_273 hydroxyurea 18.1 mM 0.968214507883652 0.193519952591874 no 688 0.166468625406677 908 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2006 4011487 200 µM 0.96793910811861 0.193587743023511 no 689 0.166537390678443 874 45595294
SGTC_1354 1498-1681 81 µM 0.96776956035758 0.193629484886542 no 690 0.166579734610232 883 5754243
SGTC_1163 k060-0048 49.9 µM 0.964212314280571 0.194506527307013 no 691 0.167469745890105 867 6809982
SGTC_439 amiodarone 34.4 µM 0.963504622747563 0.194681297251444 no 692 0.16764717270307 839 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3108 9121785 49.47 µM 0.963486594748151 0.1946857506541 no 693 0.167651694120996 833 17140271
SGTC_1699 st031318 29.054 µM 0.962646089212034 0.194893447017018 no 694 0.167862579891456 860 5340658
SGTC_3126 9127922 49.47 µM 0.962353037927938 0.194965894253801 no 695 0.167936147614676 816 45595682
SGTC_2804 7954240 19.48 µM 0.95913095946059 0.195763525895665 no 696 0.168746387822462 873 828705
SGTC_1331 1472-0049 76.2 µM 0.956989396062088 0.196294768028406 no 697 0.169286303621844 796 24051409
SGTC_1962 st076595 64.5 µM 0.956676067014556 0.196372566520837 no 698 0.169365390813587 850 279619
SGTC_998 3996-0085 177 µM 0.956430859450261 0.196433463724742 no 699 0.169427300042077 915 715391
SGTC_699 0375-0592 111 µM 0.956135330908932 0.196506873331299 no 700 0.169501933447896 890 762578
SGTC_1365 1672-3266 55.4 µM 0.955920318248761 0.196560293152278 no 701 0.169556246457015 863 6415873
SGTC_2782 7736369 71.43 µM 0.951365784937406 0.197693931476383 no 702 0.170709361395425 873 2950836 YOL077C BRX1
SGTC_2240 6690706 185.951 µM 0.950963322232376 0.197794295420044 no 703 0.170811497562713 732 805876
SGTC_3246 9135460 32.98 µM 0.950596661318883 0.197885758103932 no 704 0.170904582059606 778 41446951
SGTC_1712 st032288 53.4 µM 0.950554852842288 0.197896188750443 no 705 0.170915198071741 944 2883011
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.945263733081688 0.199218930508949 no 706 0.172262124440813 851 756377
SGTC_2293 7624732 200 µM 0.944317451818658 0.199456054090502 no 707 0.17250372521587 807 894453
SGTC_1497 4476-2978 41.3 µM 0.943329993801525 0.199703677001264 no 708 0.172756069366787 913 1528379
SGTC_1632 st005650 90 µM 0.943186673952884 0.199739632402923 no 709 0.172792714189699 825 2759605
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.942872106143234 0.199818563331429 no 710 0.172873162020919 870 2333 A French combination drug.
SGTC_3023 9089636 49.47 µM 0.942546349944617 0.199900321405947 no 711 0.172956496332372 918 17249241
SGTC_1728 st035614 33.7865 µM 0.940775429060188 0.200345137798055 no 712 0.173409977526566 915 15945546
SGTC_2260 7964312 200 µM 0.93975091952941 0.200602743363904 no 713 0.173672669807781 809 231951
SGTC_2841 9004761 38.96 µM 0.939250134818995 0.20072873441632 no 714 0.173801167010361 786 2991039
SGTC_681 1642-0006 26.6 µM 0.938653636189005 0.200878867838272 no 715 0.173954302500837 858 4446530
SGTC_2308 7584454 197.62 µM 0.937279256415762 0.201225043434504 no 716 0.174307465168065 903 893577
SGTC_2427 5545055 42.75 µM 0.935677514650337 0.201628937463236 no 717 0.174719625525163 925 5372858
SGTC_829 1635-0120 117 µM 0.932928534707926 0.202323249113976 no 718 0.175428434135962 917 285054
SGTC_1250 0485-0349 40.2 µM 0.932865303205892 0.202339236341336 no 719 0.175444759431248 831 6842794 YDL195W SEC31
SGTC_1453 4237-0541 195 µM 0.932748741363724 0.202368709401625 no 720 0.17547485623452 896 739892
SGTC_1884 5633444 25 µM 0.932485592146885 0.202435257020766 no 721 0.175542814604549 880 5724239
SGTC_648 0375-0473 33.3 µM 0.929674646274111 0.203146931215917 no 722 0.176269782738269 892 1713139
SGTC_798 1287-0182 476 µM 0.928877271694064 0.203349081815522 no 723 0.176476346495217 953 1649755
SGTC_720 r052-1644 49.9 µM 0.927246597559083 0.203762864273025 no 724 0.176899257075352 792 1422863 YOR257W CDC31
SGTC_2721 ifenprodil 61.44 µM 0.92482660256423 0.204377860694439 no 725 0.177528055220079 866 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2872 9044037 25.97 µM 0.923112134462528 0.204814228621882 no 726 0.177974385813646 858 6465195
SGTC_765 1319-0117 244 µM 0.922967939568497 0.204850954475743 no 727 0.178011956563829 838 3487746 YGL099W LSG1
SGTC_1277 0873-0036 22 µM 0.921578434646795 0.205205056378311 no 728 0.178374255742238 920 5965735
SGTC_2446 5162541 200 µM 0.921007296888217 0.205350710720728 no 729 0.178523308695152 838 1549321
SGTC_1391 3442-0225 151 µM 0.920350048174977 0.205518401470558 no 730 0.178694931549296 861 5227075
SGTC_1650 st011916 45.8 µM 0.919477949228922 0.205741034683257 no 731 0.178922817085144 904 242528
SGTC_2386 9075165 157.42 µM 0.917700972084897 0.206195111810136 no 732 0.179387719309646 890 16452277
SGTC_58 0957-0393 9 µM 0.917258662290783 0.206308229039745 no 733 0.179503556698366 990 6997992
SGTC_311 1315-0136 58 µM 0.914507377955268 0.207012673706928 no 734 0.180225151435522 894 6759207
SGTC_330 1488-0319 80.1 µM 0.909719870890806 0.208241864629296 no 735 0.18148513100293 882 6846614
SGTC_960 1222-0186 7.7 µM 0.909102252314823 0.20840075101096 no 736 0.181648076912159 903 3126296
SGTC_1745 st081495 74 µM 0.909002574526147 0.20842640046743 no 737 0.181674383415715 940 13842402 YBL026W LSM2
SGTC_256 clotrimazole 625 nM 0.90749176020331 0.208815396703668 no 738 0.182073402426856 885 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1816 st051957 91.6 µM 0.90478926433252 0.209512286620009 no 739 0.182788520109281 922 674121
SGTC_796 1234-0020 70.7 µM 0.903790350437577 0.209770221473989 no 740 0.183053289709594 872 46495034
SGTC_1016 4226-1401 38 µM 0.902218528162994 0.210176467829801 no 741 0.183470397153899 903 2901613
SGTC_652 0437-0092 114 µM 0.901906884909622 0.210257068649552 no 742 0.183553166851028 895 3091274
SGTC_53 0973-0023 39.979 µM 0.900713003161654 0.210566012218381 no 743 0.183870466597172 910 674768
SGTC_47 0149-0135 24.25 µM 0.899294013349349 0.210933553773701 no 744 0.184248037657806 928 5239155
SGTC_3106 9121286 49.47 µM 0.899152945187585 0.210970113278169 no 745 0.184285600045564 872 15943471
SGTC_261 5-fluorouridine 15.376 µM 0.897372797162154 0.211431779102645 no 746 0.184760011574065 911 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2796 7949634 45.45 µM 0.89530195649549 0.211969577272868 no 747 0.185312847361087 851 2971588
SGTC_2332 7982454 138.89 µM 0.893877896551165 0.212339870060546 no 748 0.185693612620575 913 2981748
SGTC_1306 1185-0270 9.02 µM 0.892454587929966 0.212710344931202 no 749 0.186074661605734 956 1548076
SGTC_1280 0880-0253 10.1 µM 0.89192244192897 0.212848954783311 no 750 0.186217252432996 915 6836607
SGTC_627 1391-0720 175 µM 0.890931009493242 0.213107337073421 no 751 0.186483091591036 895 997839
SGTC_2629 bisabolol 100 µM 0.888696334978835 0.213690397566654 no 752 0.187083150662688 933 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1465 k213-0056 144 µM 0.888580025668829 0.213720769850717 no 753 0.187114414925026 880 24048857 YMR208W ERG12
SGTC_2336 9001819 198.65 µM 0.88789450128971 0.213899834467665 no 754 0.187298751409391 950 2989602
SGTC_1426 4048-4480 71.7 µM 0.885808639407723 0.214445215731733 no 755 0.187860326779806 943 14224343
SGTC_440 fluspirilene 35.1 µM 0.885747325669301 0.214461259392891 no 756 0.18787684995719 924 3396 An atypical antipsychotic.
SGTC_2967 9089538 49.85 µM 0.885659939345945 0.214484126543888 no 757 0.187900400874976 951 728216
SGTC_151 3013-0144 2.285 µM 0.883453041123772 0.215062094907684 no 758 0.188495771802978 924 906558 YHR107C CDC12
SGTC_1184 1269-1718 139 µM 0.881875712137693 0.215475737854423 no 759 0.188922011315123 956 5403821
SGTC_122 0236-0016 402.397 µM 0.87921513492879 0.216174499374707 no 760 0.189642319858835 1004 6808838
SGTC_851 0394-0702 453 µM 0.878164883037937 0.21645069342307 no 761 0.189927123140112 992 762646
SGTC_2791 5663188 71.43 µM 0.876366854662479 0.216924010634732 no 762 0.19041531560825 910 54690634
SGTC_65 0798-0905 34.986 µM 0.876344751755235 0.216929832775926 no 763 0.19042132167972 991 3602145
SGTC_1229 0139-0193 12.2 µM 0.875997716245799 0.217021257467202 no 764 0.190515637652449 992 3090752
SGTC_2073 5212005 126 µM 0.875970717857119 0.217028370985013 no 765 0.190522976372726 839 691789
SGTC_808 0711-0032 135 µM 0.875329762847161 0.217197288959312 no 766 0.190697252165139 957 4252555
SGTC_2602 kawain 100 µM 0.874734317091363 0.217354281402432 no 767 0.19085924161719 994 5369129
SGTC_1481 3346-2004 36 µM 0.874285822333168 0.217472572684407 no 768 0.190981309160817 964 2770522
SGTC_993 3909-8757 62.7 µM 0.872997271909713 0.217812636822002 no 769 0.191332282350111 857 4288324 YLR208W SEC13
SGTC_3041 9091929 49.47 µM 0.871971743609103 0.218083505280757 no 770 0.191611896333774 1001 25236887
SGTC_2972 9093619 59.92 µM 0.871586684356379 0.218185259472319 no 771 0.191716948725231 893 25236256
SGTC_1338 1486-1223 76 µM 0.869291856655403 0.21879224843606 no 772 0.192343757929962 976 3444526
SGTC_1367 1812-0510 76.9 µM 0.8684715837093 0.219009448659359 no 773 0.192568110970294 934 1142582 YDR527W RBA50
SGTC_270 tamoxifen 5.46 µM 0.868380182460259 0.21903365848932 no 774 0.192593120047658 1009 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2272 7805186 180 µM 0.867452724312395 0.219279405224225 no 775 0.192847002060516 953 2956062 YPR165W RHO1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.864125400401361 0.220162342560963 no 776 0.193759503470465 934 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1198 1612-1005 86.7 µM 0.863996057494543 0.220196706063667 no 777 0.193795028164631 973 6998509
SGTC_2338 7999974 200 µM 0.862069938017189 0.220708796531762 no 778 0.194324516467611 1034 315925
SGTC_2071 5230951 39.92 µM 0.861756950240824 0.220792073845704 no 779 0.194410639614261 1038 1799272
SGTC_751 0833-0568 350 µM 0.860872167935487 0.221027587032725 no 780 0.194654226014396 947 6954252
SGTC_3194 9111903 49.47 µM 0.860120823318939 0.221227694333722 no 781 0.194861221870575 939 17087251
SGTC_71 0417-1750 47.813 µM 0.859627130558019 0.221359237036482 no 782 0.194997307350654 972 6811472
SGTC_1046 2001-0062 216 µM 0.852707963027605 0.223207525033922 no 783 0.196910636937297 925 739778
SGTC_1017 4239-0030 168 µM 0.850821067091863 0.223713083913566 no 784 0.197434378534392 937 1149593
SGTC_564 3555-0129 330 µM 0.850404386584035 0.223824813443165 no 785 0.197550149084869 885 563260
SGTC_82 0054-0107 293.755 µM 0.849821134968786 0.223981260932693 no 786 0.197712268677685 989 3104697
SGTC_2465 5809242 33.21 µM 0.849474361629968 0.22407430652346 no 787 0.197808695285825 984 2731748
SGTC_430 0958-0115 16.4 µM 0.849010527455271 0.224198795982167 no 788 0.19793771719206 903 6833180
SGTC_298 1391-0729 10 µM 0.848843496778584 0.224243635323476 no 789 0.197984191536079 962 3237558
SGTC_813 k007-0158 173 µM 0.848127096336872 0.224436010577502 no 790 0.198183596369753 1046 6523916
SGTC_2202 7226349 200 µM 0.847236714851658 0.224675235510519 no 791 0.198431596471621 946 844334
SGTC_418 lividomycin a 100 µM 0.846843262136927 0.2247809932218 no 792 0.198541245431467 1020 72394 An antibiotic.
SGTC_892 0929-0076 29 µM 0.845215758670203 0.225218756068175 no 793 0.198995192668528 1000 5751038
SGTC_325 2810-4341 181 µM 0.844520746511879 0.225405846181835 no 794 0.199189237576821 997 774970
SGTC_1128 3448-9350 235 µM 0.844099452826986 0.22551929692226 no 795 0.199306916728995 872 619386
SGTC_1899 st063254 59.6 µM 0.843710393292519 0.225624095983673 no 796 0.19941562915282 891 3093813
SGTC_814 3342-0569 96 µM 0.843369726345567 0.225715882394988 no 797 0.199510848852899 980 4346283
SGTC_2642 cholecalciferol 100 µM 0.843258179551998 0.225745941206562 no 798 0.199542033204918 981 9821465 A vitamin D precursor, similar to steriods.
SGTC_669 0108-0021 26.2 µM 0.841810711812813 0.226136199469333 no 799 0.199946957537824 1076 17201
SGTC_819 1013-0258 27.7 µM 0.840996840788826 0.226355798231272 no 800 0.20017485213013 977 5753198
SGTC_977 1348-1378 135 µM 0.840438580105347 0.226506497803273 no 801 0.200331262691949 1040 X977
SGTC_750 4073-0104 132 µM 0.839554550309448 0.226745252889649 no 802 0.200579095686503 838 22330957
SGTC_194 1486-1323 56.904 µM 0.837831821179254 0.22721092815201 no 803 0.201062582149293 996 5178754
SGTC_3352 9151559 45.5865 µM 0.836037760949952 0.2276964575388 no 804 0.201566830103167 958 17159339
SGTC_1247 0448-0043 5.84 µM 0.834571515369508 0.228093703260067 no 805 0.201979502853266 1001 3089013 YGL099W LSG1
SGTC_2644 guaiazulene 100 µM 0.832298436213464 0.228710311827928 no 806 0.202620256540213 1022 3515 A coloring agent.
SGTC_3039 9090270 49.47 µM 0.831251313956406 0.228994674826852 no 807 0.202915836001221 1003 17173750
SGTC_1781 st038725 66.3 µM 0.828600014422147 0.229715564404632 no 808 0.203665389924531 1024 4270275 YIL048W NEO1
SGTC_909 3448-9333 149 µM 0.828025728193575 0.229871880395792 no 809 0.203827964737638 934 3344074
SGTC_1969 st069479 40.1 µM 0.827718498993712 0.22995553010244 no 810 0.203914970068906 967 3895485
SGTC_1976 st070609 63.5 µM 0.827284677784774 0.230073676193988 no 811 0.204037863124836 993 682556
SGTC_3327 9140648 26.9345 µM 0.826730457325586 0.230224661001464 no 812 0.204194927107106 1002 8029710
SGTC_2253 7938677 135.83 µM 0.826640393817272 0.230249201997453 no 813 0.204220457564312 1012 2301972
SGTC_3155 9099265 49.47 µM 0.825831887874983 0.230469573615102 no 814 0.204449731246041 921 25236499
SGTC_432 NS 1619 61.3 µM 0.824514687337421 0.230828850698836 no 815 0.204823586957617 928 4552 A K+/calcium channel activator.
SGTC_1844 rapamycin 4 nM 0.823624557954511 0.231071817671933 no 816 0.205076458825892 1045 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2845 9003024 42.97 µM 0.822472974109166 0.231386362119955 no 817 0.205403880984757 1024 2990173
SGTC_2657 nystatin 74.44 µM 0.820695789938747 0.231872251744352 no 818 0.2059097847377 1044 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1103 duloxetine 36.1 µM 0.817649676409875 0.232706392252957 no 819 0.206778626624661 1107 60835 A selective serotonin reuptake inhibitor.
SGTC_3078 9116413 49.47 µM 0.816735873638643 0.232956950652203 no 820 0.207039692873278 1005 17177322
SGTC_2953 9074162 66.49 µM 0.815362655688038 0.233333759135649 no 821 0.20743237693445 955 16451992
SGTC_2802 7925815 54.55 µM 0.814057752214583 0.233692135408695 no 822 0.207805933498016 999 1262923
SGTC_2044 5102272 200 µM 0.813423514555351 0.233866431402445 no 823 0.207987641005569 960 592666
SGTC_2457 5731572 11.68 µM 0.812214860660855 0.234198783104147 no 824 0.208334176921141 1060 2865357
SGTC_3242 9133940 49.47 µM 0.811134515964027 0.234496073953472 no 825 0.208644213095858 1085 17248444
SGTC_684 1140-0066 328 µM 0.808881701705222 0.235116677760032 no 826 0.209291597545307 1066 6813534
SGTC_477 mead ethanolamide 10 µM 0.805507309927856 0.236047947688628 no 827 0.210263494892817 904 16061185
SGTC_1454 4239-0054 42.6 µM 0.804614344867575 0.236294729231876 no 828 0.210521130816832 1077 1340767
SGTC_3064 1327-0027 10 µM 0.804377721438029 0.236360146740797 no 829 0.210589431823467 904 16000455 YPR107C YTH1
SGTC_1313 1220-0047 237 µM 0.804037387799312 0.236454253716016 no 830 0.210687691427451 1057 3528706
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.800957596037992 0.237306795922764 no 831 0.211578097373199 1056 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1255 0566-0045 221 µM 0.799131592820587 0.23781306277392 no 832 0.212107056182389 1027 2788469
SGTC_1055 3448-0672 86 µM 0.797963956753352 0.238137104881829 no 833 0.21244570332921 993 748378
SGTC_1968 st069590 43.6 µM 0.796282511052284 0.238604164101613 no 834 0.212933924214643 1024 6384066
SGTC_1133 3473-0247 50 µM 0.794921289020661 0.238982640944266 no 835 0.213329644801999 970 711311
SGTC_2659 sanguinarine 24.21 µM 0.79404476281515 0.239226525633942 no 836 0.213584686337847 1011 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_616 4092-0450 108 µM 0.793815812676554 0.239290251122963 no 837 0.213651332872998 1069 787165
SGTC_1106 tegaserod maleate 11.7 µM 0.792236790180086 0.239730005280957 no 838 0.214111310261252 1045 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2907 7721985 69.9 µM 0.791268655935245 0.239999846379745 no 839 0.214393617513654 1058 3267881
SGTC_1327 1436-0082 2.18 µM 0.790149520194123 0.240311981310505 no 840 0.214720226280506 1014 15992205
SGTC_2687 chenodiol 100 µM 0.789579678315186 0.240470999209276 no 841 0.21488664006028 1007 5702181 A cholesterol synthesis inhibitor.
SGTC_90 0870-0863 4.608 µM 0.789320154184422 0.24054344000997 no 842 0.214962455015253 1051 1738164
SGTC_2315 7733312 200 µM 0.789053434270263 0.240617901744125 no 843 0.215040388263201 1016 726316
SGTC_2110 5483698 200 µM 0.788725602190648 0.240709441700784 no 844 0.215136200427607 1050 2848765 YHR062C RPP1
SGTC_1620 st003704 16.5 µM 0.788269538966877 0.240836818924811 no 845 0.215269530620204 1055 2834414
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.788173739449292 0.240863580130761 no 846 0.215297543725296 1027 75037 A free radical scavenger.
SGTC_3278 9139605 49.47 µM 0.788121269014299 0.240878238219207 no 847 0.215312887703391 1037 7958859
SGTC_231 b-estradiol 524 µM 0.787998537762265 0.24091252619447 no 848 0.215348780595446 1008 450 A steroid.
SGTC_1800 st050079 29.0735 µM 0.787932923438811 0.240930858248613 no 849 0.215367971001853 1094 3645560
SGTC_957 1187-1561 14.1 µM 0.785948694847825 0.241485592197522 no 850 0.215948772465888 1077 1538454
SGTC_560 2332-1943 155 µM 0.785098154538668 0.241723591345059 no 851 0.216198010832767 1061 21177716
SGTC_2187 6125751 200 µM 0.78412299545589 0.241996618045709 no 852 0.216483971762991 1040 874498
SGTC_1770 st043884 66.3 µM 0.78282198486049 0.242361137488674 no 853 0.216865827731098 1089 670149
SGTC_349 k015-0014 24 µM 0.782577513407787 0.242429667121628 no 854 0.216937625296068 1012 2196908
SGTC_2688 kanamycin b 96.69 µM 0.781602220759583 0.242703163189819 no 855 0.217224190686588 1266 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_567 1080-0542 68.4 µM 0.78110942700717 0.242841418183369 no 856 0.217369068936727 1021 5950415
SGTC_1563 conessine 56.1 µM 0.780069945016106 0.243133188165643 no 857 0.217674852977225 1167 441082 An anti-amoebic, histamine inhibitor.
SGTC_2078 5212016 200 µM 0.780005756952867 0.243151211187937 no 858 0.217693743289352 1030 1899708
SGTC_1119 parthenolide 318.541 nM 0.778797512377672 0.243490602445024 no 859 0.218049501675475 1115 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3182 9108849 49.47 µM 0.77777858394944 0.243777014305864 no 860 0.218349777690057 1120 17133045
SGTC_2207 7258803 200 µM 0.777317935010879 0.243906558355681 no 861 0.21848560808979 1040 3666799
SGTC_2363 9053361 176 µM 0.776999722335721 0.243996068057796 no 862 0.218579467074353 1082 6469797 YMR079W SEC14
SGTC_1520 flindersine 88 µM 0.774306854715659 0.244754250899627 no 863 0.219374675514366 1115 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_821 1114-0266 29.2 µM 0.77301302762184 0.24511898136688 no 864 0.2197573353478 1046 3123235
SGTC_192 3455-0609 60.9 µM 0.772025188723277 0.245397650286731 no 865 0.22004975448969 1095 3769639
SGTC_2732 terfenadine 20 µM 0.771956933937156 0.245416911218338 no 866 0.220069967448526 1080 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_462 ag-879 158 µM 0.770964978672613 0.245696924398309 no 867 0.220363845078668 1112 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2254 7938975 95.19 µM 0.769272764160513 0.246175005306315 no 868 0.220865701061889 1116 2969277
SGTC_586 0957-0265 8.15 µM 0.768281350257404 0.246455329070515 no 869 0.22116002602611 1007 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1927 st060202 13.8 µM 0.768207563991093 0.246476199084519 no 870 0.22118194021485 1070 688887
SGTC_802 4112-3352 742 µM 0.766381289705876 0.24699305172935 no 871 0.221724731190214 1113 704594
SGTC_2596 sinensetin 100 µM 0.76338383618826 0.247842614459947 no 872 0.222617258420785 1058 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1443 4112-3303 14 µM 0.762678736551135 0.248042685939874 no 873 0.222827507350485 1115 704433
SGTC_2001 4023502 57.655 µM 0.76228586296494 0.248154200888395 no 874 0.222944704755089 1076 108941 YCR052W RSC6
SGTC_1923 st058458 19.1 µM 0.75828794331506 0.249290506731229 no 875 0.224139311725859 1151 3534982
SGTC_2206 7254556 146.969 µM 0.752545904714216 0.250927361150387 no 876 0.225861417478219 1105 4398905
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.750336433497514 0.251558716281746 no 877 0.226526052440044 1086 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1226 3909-7979 35.4 µM 0.749464279729075 0.251808164550468 no 878 0.226788710209718 1127 6615510
SGTC_2905 7799065 20.05 µM 0.748042166221055 0.252215188963508 no 879 0.227217362108712 1076 1296806
SGTC_1122 capsaicin 818.572 nM 0.746886539575937 0.252546197269365 no 880 0.227566025857947 1121 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_596 1155-0152 116 µM 0.746680415290965 0.252605261877865 no 881 0.22762824719603 1128 280313
SGTC_1700 st030840 7.9285 µM 0.746415012428419 0.2526813233902 no 882 0.227708376660185 1118 5499307
SGTC_3172 9105863 49.47 µM 0.744772756002056 0.253152243943367 no 883 0.228204553671997 1087 2348785
SGTC_944 3370-0224 231 µM 0.743455595987519 0.253530275717516 no 884 0.228602947755401 1148 4580514
SGTC_485 niflumic acid 177 µM 0.743334712534397 0.253564984750153 no 885 0.228639530262313 1093 4488 A COX2 inhibitor.
SGTC_3320 9137005 35.139 µM 0.743333724021263 0.253565268590311 no 886 0.228639829425893 1069 4908713
SGTC_2877 9040724 71.43 µM 0.741735738364678 0.254024329905216 no 887 0.229123731062533 1119 6463895
SGTC_1910 st062352 60.4 µM 0.739604038405452 0.25463739212388 no 888 0.229770145267749 1123 2245730
SGTC_1625 st003711 30.1 µM 0.738980083225267 0.254816983825747 no 889 0.229959545730314 1148 24207034 YER133W GLC7
SGTC_1220 1838-0075 193 µM 0.73868203704394 0.254902793223069 no 890 0.230050047937825 1089 5529645
SGTC_3129 9127257 49.47 µM 0.737522383106747 0.255236808824592 no 891 0.230402368311665 1058 837894
SGTC_77 0828-0286 12.516 µM 0.735747118066577 0.255748582103383 no 892 0.230942304540599 1126 745345
SGTC_2962 9082311 13.18 µM 0.735706576095972 0.255760275793566 no 893 0.230954643383165 1128 16459453
SGTC_2753 fluvastatin 17.09 µM 0.735435749815194 0.255838398510479 no 894 0.231037078092869 1119 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_227 fluconazole 33.516 µM 0.735354165248526 0.255861934886064 no 895 0.23106191420442 1139 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3193 9111931 49.47 µM 0.732870018400721 0.256579128451362 no 896 0.231818855442231 1171 17087244
SGTC_1253 0550-0034 176 µM 0.730154895747764 0.257364202548882 no 897 0.232647754591253 1092 5969915
SGTC_3199 9111318 49.47 µM 0.729051621554119 0.257683569113174 no 898 0.232985043062817 1087 8548020
SGTC_1624 st003710 6.25 µM 0.728951034615456 0.257712696407985 no 899 0.233015807593134 1163 24207033
SGTC_416 estradiol valerate 100 µM 0.728887153643385 0.25773119552119 no 900 0.233035346769298 1159 13791 A steroid.
SGTC_141 0443-0274 32.331 µM 0.727636019927705 0.25809364676598 no 901 0.233418212501311 1262 1627241
SGTC_1852 st056254 31.4 µM 0.727580794370201 0.258109651602104 no 902 0.233435120390248 1112 442583
SGTC_2541 muurolladie-3-one 83.07 µM 0.727165336767691 0.258230071244293 no 903 0.233562338911109 1168 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_881 0833-0569 170 µM 0.726675605338716 0.258372056409297 no 904 0.23371235040441 1127 5418700
SGTC_716 1683-5115 658 µM 0.726530264868317 0.25841420196242 no 905 0.233756880471033 1193 723597
SGTC_989 1501-0895 10.3 µM 0.726384884124816 0.258456362756706 no 906 0.233801427581031 1156 2830112
SGTC_1282 0886-0010 32.4 µM 0.723885248413058 0.25918182054508 no 907 0.234568093544567 1212 2836211 YNL267W PIK1
SGTC_2702 st077768 96.8 µM 0.723876103829421 0.259184476466679 no 908 0.234570900840173 1080 6484119
SGTC_3338 9144300 39.5675 µM 0.721540633603627 0.259863242769622 no 909 0.235288474925023 1139 4901274
SGTC_3019 9081971 49.47 µM 0.720530581156537 0.260157081835791 no 910 0.235599188904579 1190 16451803
SGTC_2167 5876490 200 µM 0.719795435965705 0.26037105398512 no 911 0.235825477712537 1165 686534
SGTC_2744 captopril 92.04 µM 0.719400899505697 0.260485925561263 no 912 0.23594697139424 1119 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2492 derrusnin 100 µM 0.718120900400496 0.260858784313269 no 913 0.23634137212517 1093 1715307 Part of coumarin class of compounds.
SGTC_1263 0774-1208 64.8 µM 0.717066234162757 0.261166210640834 no 914 0.236666614545809 1198 906585
SGTC_468 gf-109203x 121 µM 0.71678183095036 0.261249143645923 no 915 0.23675436213814 1077 2396 A protein kinase C inhibitor.
SGTC_1653 st012112 65 µM 0.715602038104993 0.261593319935876 no 916 0.237118557394461 1140 720429
SGTC_1870 st057514 26.5 µM 0.715132968847054 0.261730224282248 no 917 0.237263441848906 1175 5393161
SGTC_33 0986-0033 35.816 µM 0.712915127399964 0.262378029400396 no 918 0.237949138874429 1123 2848082
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.712776558366796 0.262418531002622 no 919 0.237992016729953 1195 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1183 1254-0324 198 µM 0.712737577680373 0.262429925036041 no 920 0.238004079410707 1188 5799357
SGTC_306 1672-3436 11.6 µM 0.712134825096286 0.262606141522651 no 921 0.238190645509428 1188 6797378
SGTC_1249 0481-0015 10.2 µM 0.710126865203244 0.263193611022804 no 922 0.238812734000561 1150 4227577
SGTC_45 0kpi-0036 14.9 µM 0.709391699395842 0.263408866504194 no 923 0.239040718672484 1159 2795021
SGTC_64 000l-0018 272.079 µM 0.709059330846386 0.263506213026067 no 924 0.239143829611952 1137 6811119
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.707990546469531 0.263819370782499 no 925 0.239475564073392 1203 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_414 piperonyl butoxide 100 µM 0.707703624864766 0.263903472166733 no 926 0.239564662951326 1173 5794 A potent inhibitor of cytochrome P450.
SGTC_2480 5767542 37.17 µM 0.705192517374741 0.264640101325863 no 927 0.240345218620546 1186 2867358
SGTC_673 1082-0474 110 µM 0.704350009500618 0.264887483694339 no 928 0.240607414850666 1225 3098046
SGTC_1214 0358-0031 63.7 µM 0.703501899653913 0.265136629604325 no 929 0.24087151166068 1192 4301366
SGTC_1828 st055811 49 µM 0.702544874154436 0.265417914093437 no 930 0.241169713491698 1149 5877589
SGTC_2665 lovastatin 100 µM 0.70106178712885 0.265854115109295 no 931 0.241632228258829 1185 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1246 0422-0085 105 µM 0.69866901720637 0.266558634350715 no 932 0.24237945037988 1194 264295
SGTC_2940 9060638 45.86 µM 0.696127404824958 0.267308010946539 no 933 0.243174522756774 1181 4027022
SGTC_1669 st015249 58.4 µM 0.694318961364228 0.26784186431066 no 934 0.243741101203531 1273 722793
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.693954175372115 0.267949614365246 no 935 0.243855473574218 1067 6708630 An antioxidant.
SGTC_463 ikarugamyin 104 µM 0.693195887632119 0.268173666326214 no 936 0.244093314295192 1224 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2432 5630864 12.22 µM 0.692737033481902 0.268309290145345 no 937 0.244237296916734 1171 5714970
SGTC_295 k015-0027 31 µM 0.692426452003199 0.268401108490437 no 938 0.244334779429702 1177 3887424
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.690432074638819 0.268991089861951 no 939 0.244961255983646 1189 61125 An anti-inflammatory.
SGTC_2730 imipramine 71.33 µM 0.690425546446236 0.268993022115522 no 940 0.244963308046616 1224 3696 A tricyclic antidepressant.
SGTC_1908 st060353 56.5 µM 0.688687313753371 0.269507762425951 no 941 0.245510030648756 1234 4227716
SGTC_2327 6189656 200 µM 0.688635592240058 0.269523086201788 no 942 0.245526308542601 1226 5349088
SGTC_126 0417-1624 672.48 µM 0.688620273652256 0.269527624795603 no 943 0.245531129749216 1302 41912 YDL195W SEC31
SGTC_1244 0416-0015 52.5 µM 0.688583068509575 0.269538648101118 no 944 0.245542839505115 1210 96201
SGTC_980 1473-0395 201 µM 0.687195673062187 0.269949873035476 no 945 0.245979715338623 1161 768876
SGTC_2650 prasterone 100 µM 0.6868391406454 0.270055600172868 no 946 0.246092050865853 1168 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2848 9016370 25.97 µM 0.68133841353465 0.271689422413952 no 947 0.247828691112699 1228 7894410
SGTC_2436 5633522 8.09 µM 0.680615948685433 0.271904373439 no 948 0.248057266313316 1215 5724242
SGTC_2096 5468907 200 µM 0.680557604348856 0.27192173600236 no 949 0.248075730344534 1229 759785
SGTC_937 3122-0005 46.7 µM 0.675701534645144 0.273368773419926 no 950 0.24961508071083 1218 759535
SGTC_2185 6113692 200 µM 0.675296501552764 0.273489639399512 no 951 0.249743703084404 1219 874150
SGTC_2517 totarol 10 µM 0.674494790622554 0.273728956038249 no 952 0.249998398273273 1192 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1082 camptothecin 424.86 nM 0.674490759476595 0.273730159626791 no 953 0.249999679274407 1175 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2884 9058502 51.95 µM 0.671508561200553 0.274621278042648 no 954 0.250948303713782 1226 6471554
SGTC_1579 chlormadinone acetate 49.4 µM 0.669724073685184 0.275155188812709 no 955 0.251516851188207 1242 45114258 A steroidal progestin.
SGTC_87 0100-0052 35.5 µM 0.66910322390372 0.275341064096604 no 956 0.251714816791766 1301 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2976 9009005 19.48 µM 0.668969767084616 0.275381027600828 no 957 0.25175738188558 1262 2993148
SGTC_1587 estradiol valerate 56.1 µM 0.667843709171667 0.275718338052665 no 958 0.252116681238659 1235 13791 A steroid.
SGTC_746 1095-0025 46.6 µM 0.664966779830938 0.276581042863923 no 959 0.253035870554674 1240 6749286
SGTC_1262 0737-0114 49.6 µM 0.664586587982675 0.27669514990114 no 960 0.253157474988697 1274 765919
SGTC_559 1550-0661 158 µM 0.663657341759558 0.276974141764491 no 961 0.253454823889439 1272 5830875
SGTC_1525 8-methoxypsoralen 92.5 µM 0.661943083676846 0.277489182438707 no 962 0.254003849449723 1291 4114 Related to psoralen; DNA damaging agent.
SGTC_2190 6049624 200 µM 0.660070274521724 0.278052393530465 no 963 0.254604366643913 1198 2265554
SGTC_775 4577-0580 57.3 µM 0.658579566659042 0.278501093323319 no 964 0.255082893866483 1312 2006902
SGTC_2084 5306078 60.6385 µM 0.651541076661706 0.280624415251306 no 965 0.257348635039257 1218 679340
SGTC_2114 5491910 81.25 µM 0.649003315991609 0.281391905436164 no 966 0.258168116432136 1314 2849228
SGTC_1784 st039334 36.3 µM 0.648078771763395 0.281671765141568 no 967 0.258467001644096 1333 3496984
SGTC_547 1120-0019 610 nM 0.647606843311048 0.281814669685628 no 968 0.258619635003203 1247 3676939
SGTC_2391 6285546 200 µM 0.646338771096892 0.282198827321569 no 969 0.259029992041478 1238 846083
SGTC_1590 st077108 57.8 µM 0.64622007113262 0.282234799919724 no 970 0.259068421408058 1257 5489485
SGTC_848 0368-0089 85.6 µM 0.642202662565036 0.283453594468457 no 971 0.260370802229551 1252 762535
SGTC_497 capsazepine 133 µM 0.641694396797987 0.283607970863628 no 972 0.260535814028041 1230 2733484 A calcium channel blocker.
SGTC_2136 5328288 199.296 µM 0.640318120174633 0.284026191704621 no 973 0.260982901356537 1256 262395
SGTC_111 0083-0039 52.457 µM 0.640317500188643 0.284026380171486 no 974 0.260983102849589 1200 759313
SGTC_1797 st048695 56.8 µM 0.640067963647564 0.284102240565421 no 975 0.261064207756193 1258 592262 YIL048W NEO1
SGTC_2862 9027634 71.43 µM 0.635977358592211 0.285347185031157 no 976 0.262395589741903 1241 5012562
SGTC_2328 6201408 200 µM 0.634471402562925 0.285806164770721 no 977 0.262886612076384 1264 2890418
SGTC_395 anisomycin 6.25 µM 0.63436830613966 0.285837598955772 no 978 0.262920244207367 1242 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1608 st001473 40.5 µM 0.634132256979752 0.285909576731159 no 979 0.26299725648382 1250 7292267
SGTC_1842 st055362 61.2 µM 0.633182132577223 0.286199382477948 no 980 0.263307356119137 1291 676032
SGTC_1889 st059080 5.18 µM 0.632095264769591 0.286531068507239 no 981 0.263662314605693 1290 176925 Isolated from Daphnopsis sellowiana.
SGTC_2107 5363541 170.161 µM 0.632029241925296 0.286551222972391 no 982 0.263683884766779 1275 244052
SGTC_2499 avocadenofuran 51.48 µM 0.63124129230736 0.28679180832228 no 983 0.263941383305985 1241 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2423 st077119 87.2 µM 0.631043113323564 0.286852333550869 no 984 0.264006167509884 1256 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2229 7354935 190 µM 0.630379592684742 0.287055021379263 no 985 0.264223129680551 1251 318112
SGTC_1611 st001856 99.4 µM 0.627589241327463 0.287908140669193 no 986 0.265136529199143 1253 647478
SGTC_1064 honokiol 6.76 µM 0.626809467374931 0.288146761851131 no 987 0.265392068446949 1289 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_692 k241-0027 77.8 µM 0.623418232800737 0.289185608481273 no 988 0.266504859752364 1376 3600480
SGTC_800 3448-7362 155 µM 0.621803847771406 0.289680765554567 no 989 0.2670354279604 1369 15991913
SGTC_1830 st055982 50.3 µM 0.621667760920774 0.289722523693746 no 990 0.267080177316269 1280 455313 An antimicrobial agent.
SGTC_1431 4049-0260 9.09 µM 0.619666601550984 0.290336903748067 no 991 0.267738654232682 1311 3854841
SGTC_391 gliotoxin 8.33 µM 0.619222784046697 0.290473243686446 no 992 0.267884802122002 1358 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_438 sphingosine 6.67 µM 0.618696871987449 0.290634841708143 no 993 0.26805803552515 1182 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1993 st073995 70.8 µM 0.617985645372221 0.290853448565044 no 994 0.268292400495859 1321 3098394
SGTC_2593 nobiletin 86.24 µM 0.617761120840185 0.290922475723774 no 995 0.268366407717785 1264 72344 An anti-infammatory.
SGTC_2144 5628481 200 µM 0.617744495904925 0.290927587149161 no 996 0.268371887996133 1301 2818399
SGTC_3150 9097574 49.47 µM 0.617085517230959 0.291130227465226 no 997 0.268589160421631 1310 17217476
SGTC_3044 9093193 49.47 µM 0.616665794931093 0.291259329210142 no 998 0.268727593493955 1275 25236277
SGTC_2677 mitomycin C 100 µM 0.615620797574552 0.29158087440025 no 999 0.269072410821897 1320 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1872 amphotericin b 148 nM 0.615066733567677 0.291751426748449 no 1000 0.269255325115082 1306 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_739 1486-1183 203 µM 0.613901752166825 0.292110183641072 no 1001 0.26964012614303 1326 4346692
SGTC_2622 2-methoxyxanthone 59.94 µM 0.61312304705203 0.292350100890721 no 1002 0.269897491101584 1361 71034 A hepatoprotective.
SGTC_1231 0242-0792 125 µM 0.612922786846501 0.292411815407526 no 1003 0.269963697722117 1299 3707635
SGTC_1156 4092-0367 4.88 µM 0.612727694065031 0.292471943294565 no 1004 0.270028203791991 1320 1357585
SGTC_1086 cerivastatin 2.18 µM 0.611752513868696 0.292772581413528 no 1005 0.270350755913496 1299 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1322 1348-1070 12 µM 0.6108857278327 0.29303992311124 no 1006 0.270637616998191 1301 6758089
SGTC_760 0568-0725 82.9 µM 0.609824052929199 0.293367528345917 no 1007 0.270989183162931 1332 3916171
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.608928504573768 0.293644003133211 no 1008 0.27128591473712 1325 16623 A steroid.
SGTC_307 1501-1223 22.3 µM 0.606211681089538 0.294483481295365 no 1009 0.272187098511632 1304 2830329
SGTC_2241 6772625 37.8075 µM 0.605482760118508 0.294708900747633 no 1010 0.272429138110436 1261 2285411
SGTC_531 3788-1495 174 µM 0.605130924240692 0.294817734770184 no 1011 0.272546004123092 1318 2896655
SGTC_1483 3453-0561 55.9 µM 0.603626508711034 0.295283307176393 no 1012 0.273045992243943 1343 4546991
SGTC_641 4092-0595 30 µM 0.602237239658418 0.295713545407532 no 1013 0.273508115211653 1355 786260
SGTC_1389 3405-0187 19 µM 0.601201789754563 0.296034397773341 no 1014 0.273852796280749 1286 799890
SGTC_1578 josamycin 24.2 µM 0.599738963743194 0.296487952270346 no 1015 0.274340108264226 1270 5282165 A P450 substrate.
SGTC_735 3076-0345 636 µM 0.599199098181427 0.296655419951314 no 1016 0.274520062045703 1409 2888990
SGTC_1917 st066507 28.5 µM 0.598110095343836 0.296993363184964 no 1017 0.27488323729587 1354 3156428
SGTC_2537 larixol 68.93 µM 0.596131102529896 0.297607941619418 no 1018 0.275543823858372 1323 6708759
SGTC_864 0469-0573 172 µM 0.595157587586717 0.297910480625527 no 1019 0.275869068786356 1302 689425
SGTC_2349 9023730 187.07 µM 0.594546737121017 0.298100386044506 no 1020 0.276073246161376 1408 4126287
SGTC_2447 5741742 33.78 µM 0.593181295051977 0.298525083427814 no 1021 0.276529914639571 1424 1776504
SGTC_3356 9151811 4.48 µM 0.591850833875446 0.298939165159594 no 1022 0.276975239788005 1334 1859254 YPR165W RHO1
SGTC_2352 9027995 87.8 µM 0.591051326703252 0.299188122584812 no 1023 0.277243015507443 1357 2997347
SGTC_618 k072-0232 33.2 µM 0.590154362339568 0.299467539006688 no 1024 0.277543582816146 1361 5872756 YGL099W LSG1
SGTC_3042 9091578 49.47 µM 0.586038172673646 0.300751301592436 no 1025 0.278924931449001 1324 25236497
SGTC_1891 st059073 26.2 µM 0.585165033489057 0.30102393629757 no 1026 0.279218376911067 1410 688754
SGTC_1568 digitonin 820 nM 0.584805358301234 0.301136276026141 no 1027 0.279339300517168 1450 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2618 avocadyne 43.43 µM 0.584635790849089 0.301189244700573 no 1028 0.279396318299291 1332 3015189
SGTC_161 4065-0411 162.148 µM 0.58445865479758 0.301244582100109 no 1029 0.279455887092197 1398 1906281 YLR208W SEC13
SGTC_1791 st048313 56.1 µM 0.584321787961734 0.301287342510442 no 1030 0.279501918040197 1330 1204976
SGTC_1754 st042065 16.137 µM 0.584127865182363 0.301347933215637 no 1031 0.279567144302057 1305 1126236 YIL048W NEO1
SGTC_2148 5546263 113.568 µM 0.58297242135822 0.301709062522374 no 1032 0.279955932943487 1354 792097
SGTC_2334 9017922 200 µM 0.581283376683607 0.302237316446626 no 1033 0.280524741151956 1445 3163164
SGTC_1743 st037606 46.3785 µM 0.5810720549085 0.302303437185643 no 1034 0.280595945911894 1404 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3203 9113543 49.47 µM 0.579407677798821 0.302824432933074 no 1035 0.281157062363778 1421 17018012
SGTC_107 0358-0022 2.6945 µM 0.57885181457246 0.302998522908053 no 1036 0.281344582849198 1419 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2188 6126565 140.678 µM 0.578568691953265 0.303087210870195 no 1037 0.281440117476674 1375 874518
SGTC_2101 5377231 179.231 µM 0.57833670487737 0.303159889313839 no 1038 0.281518409002169 1436 2844213
SGTC_1806 st050005 60.3 µM 0.576570970504573 0.303713325467209 no 1039 0.282114657111309 1329 5194765
SGTC_1526 st051518 75 µM 0.574205862958927 0.30445532941464 no 1040 0.28291425116786 1372 673993
SGTC_1366 1683-0113 21.9 µM 0.573890613390559 0.304554293403409 no 1041 0.283020912679738 1370 708623
SGTC_213 1246-0773 967 nM 0.571512426695626 0.305301320849079 no 1042 0.28382616959532 1382 6251622
SGTC_1711 st032263 62.8 µM 0.570944630353083 0.305479795131578 no 1043 0.284018588202489 1400 3958979
SGTC_1088 bifonazole 369 nM 0.569993723007619 0.305778795471807 no 1044 0.284340977730862 1320 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1154 4088-0362 150 µM 0.569618012303459 0.305896968481924 no 1045 0.284468404462147 1364 6618304
SGTC_1333 1482-0047 286 µM 0.569072114570483 0.306068706759155 no 1046 0.284653600738095 1350 3811116
SGTC_1998 st075797 76.8 µM 0.56899059334576 0.306094356824507 no 1047 0.284681261822716 1378 24208315
SGTC_486 niguldipine 82 µM 0.564901277013095 0.30738224856426 no 1048 0.286070457524045 1392 1236 A calcium channel blocker.
SGTC_223 busulfan 5 mM 0.563192396753807 0.307921150002837 no 1049 0.286651939852906 1406 2478 A DNA alkylator.
SGTC_2079 5212404 121 µM 0.562541847090311 0.308126412144919 no 1050 0.286873450221228 1443 758462
SGTC_1630 st005209 31.3 µM 0.562530311819412 0.308130052308015 no 1051 0.286877378680957 1410 3367314
SGTC_1567 st069303 68.4 µM 0.562087482677222 0.308269809309277 no 1052 0.287028208145598 1412 5581319
SGTC_1936 st074407 74.3 µM 0.561357062644641 0.30850039080706 no 1053 0.287277074307995 1391 809813
SGTC_2835 9006588 71.43 µM 0.56114650075703 0.308566875737617 no 1054 0.287348835174815 1392 2345538
SGTC_1793 st048256 72.231 µM 0.561126260105228 0.308573267055539 no 1055 0.287355733767939 1332 672022
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.55850153340155 0.309402558417952 no 1056 0.288250978860234 1418 66535 A nucleotide analog.
SGTC_2222 6885208 172.143 µM 0.5583948331536 0.309436291305813 no 1057 0.288287400123578 1375 609514
SGTC_2726 cimetidine 79.27 µM 0.557971461146626 0.309570154621076 no 1058 0.288431936106085 1396 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2575 plumbagin 510 nM 0.556296489795132 0.31010000079815 no 1059 0.289004093200007 1346 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_527 4476-4215 268 µM 0.55589448698677 0.310227225694381 no 1060 0.289141493620565 1427 4418754
SGTC_2545 solidagenone 89.61 µM 0.553512483702717 0.310981542122196 no 1061 0.289956267359214 1316 6708572 An anti ulcer agent
SGTC_588 3970-1144 52.9 µM 0.553501840827482 0.310984914220648 no 1062 0.289959910211806 1396 1888707
SGTC_1814 st052110 31.539 µM 0.553393311299222 0.311019301722978 no 1063 0.289997059018247 1437 674163
SGTC_562 3772-2733 112 µM 0.553369203422556 0.311026940510199 no 1064 0.290005311258245 1405 2876874 YIL048W NEO1
SGTC_3104 9120930 49.47 µM 0.55322176841504 0.311073658326559 no 1065 0.29005578135263 1392 17014836
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.553064418017529 0.311123521396662 no 1066 0.290109650234214 1453 65057 A dermal irritant. YDR527W RBA50
SGTC_1314 1222-0010 41.1 µM 0.552613223053802 0.311266520657332 no 1067 0.290264142744543 1416 3526027
SGTC_667 1498-1044 59 µM 0.551151765196985 0.311729902595789 no 1068 0.29076482116007 1456 6739982
SGTC_283 0987-0079 11.7 µM 0.550868794408953 0.311819658145741 no 1069 0.29086181029586 1438 411556
SGTC_853 0419-0306 21 µM 0.550642042027985 0.311891589837823 no 1070 0.290939541306828 1348 762713
SGTC_2798 7813637 45.45 µM 0.550135239551577 0.312052386566739 no 1071 0.291113308940173 1456 956368
SGTC_2374 9071832 200 µM 0.550086433431334 0.312067873513505 no 1072 0.29113004567879 1374 17381698
SGTC_1310 1188-0297 994 nM 0.549748229276255 0.312175200116566 no 1073 0.291246035988433 1386 1588352
SGTC_1085 doxorubicin 7.67 µM 0.549123059331377 0.312373635171556 no 1074 0.291460500701372 1476 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1560 lithocholic acid 53.1 µM 0.548819839311504 0.312469899775891 no 1075 0.291564546931229 1388 9903 A bile acid which acts as a detergent.
SGTC_2038 4100038 30.985 µM 0.546979477376424 0.313054442017888 no 1076 0.292196415799267 1443 3596803
SGTC_1643 st009866 20.2 µM 0.544890233590116 0.313718604871484 no 1077 0.29291450684142 1424 3156273 YOR207C RET1
SGTC_2583 asiatic acid 100 µM 0.544299892827315 0.313906381582251 no 1078 0.293117560343099 1412 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1615 st002656 86.5 µM 0.543876642518601 0.314041039516404 no 1079 0.293263181610213 1400 1584458
SGTC_2292 7671323 168.05 µM 0.543693246449804 0.314099395034119 no 1080 0.293326290305222 1404 937504
SGTC_245 methotrexate 289.6 µM 0.540670400472489 0.315061915130201 no 1081 0.294367391919825 1452 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1400 3771-8998 51.5 µM 0.539799738578186 0.315339380588365 no 1082 0.294667573692383 1434 670767
SGTC_1107 amlodipine 47 µM 0.537742619665264 0.315995363797235 no 1083 0.295377375542554 1351 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_505 gw-5074 63.9 µM 0.536832845572624 0.316285661636107 no 1084 0.29569154066247 1484 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1030 k029-0042 36.7 µM 0.536312549274522 0.316451732773651 no 1085 0.295871279479796 1471 6080581
SGTC_2419 paclitaxel 166.5 µM 0.533602195131775 0.317317437114942 no 1086 0.296808394603265 1374 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_536 3852-0578 10.6 µM 0.532642487168842 0.317624214019855 no 1087 0.297140542637873 1527 2869208
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.530975954821655 0.318157229498674 no 1088 0.297717720901477 1484 676296 Flavone; oxidizing agent.
SGTC_3013 9080133 71.4286 µM 0.528740702155302 0.318872733199565 no 1089 0.298492668911612 1510 17050193
SGTC_218 alverine citrate 93.75 µM 0.528420910717145 0.318975153644447 no 1090 0.298603613586964 1484 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1343 1487-0095 224 µM 0.526673359610105 0.319535090437832 no 1091 0.299210219355321 1453 4560101 YGL055W OLE1
SGTC_1199 1638-0010 4.46 µM 0.526504129615287 0.319589335686186 no 1092 0.299268991753076 1419 3111136
SGTC_105 0111-0055 734.78 µM 0.526377353376622 0.319629975269992 no 1093 0.299313023688308 1416 5179370
SGTC_2340 7987427 183.45 µM 0.526116565208687 0.319713580731548 no 1094 0.299403609898343 1479 2239331
SGTC_222 nsc-310342 10.666 µM 0.524935836885145 0.320092222219435 no 1095 0.299813897869222 1473 432556
SGTC_2786 7743617 45.45 µM 0.524384700623854 0.320269027373538 no 1096 0.30000549776768 1352 583674
SGTC_1652 st011932 78 µM 0.52154997269138 0.321179055458419 no 1097 0.300991851504895 1498 1551076
SGTC_1479 0549-0158 134 µM 0.520808534752865 0.321417255628386 no 1098 0.301250078494739 1470 5440202
SGTC_714 4296-0578 26.1 µM 0.520566191533889 0.321495128647058 no 1099 0.30133450309079 1470 1589775
SGTC_1496 4469-0713 57.4 µM 0.519877185023271 0.321716572441399 no 1100 0.301574589013421 1496 746691
SGTC_2143 5623677 140.463 µM 0.519472754177546 0.321846584325249 no 1101 0.301715553950228 1446 5375313
SGTC_176 1486-1328 72.834 µM 0.518473147202898 0.322168020304306 no 1102 0.302064095396583 1445 22310231
SGTC_1219 1469-0211 33.1 µM 0.518395270385811 0.322193068147064 no 1103 0.302091256957233 1460 6822282
SGTC_109 0132-0036 33.701 µM 0.516961130024226 0.322654480904786 no 1104 0.302591646530766 1388 67274 A color developer.
SGTC_964 1287-0107 19.4 µM 0.516499592249975 0.322803031782949 no 1105 0.302752761826112 1553 51516812 YPR165W RHO1
SGTC_1895 st058434 18.3 µM 0.515924372419388 0.32298821203378 no 1106 0.302953615435886 1510 5393175
SGTC_2468 5987765 72.9 µM 0.513764705731479 0.323683863927477 no 1107 0.303708253351223 1515 26772094
SGTC_755 1995-0008 37.3 µM 0.51362478267885 0.323728955940497 no 1108 0.303757174655334 1449 689533
SGTC_2228 7354201 200 µM 0.513395735365569 0.323802774983786 no 1109 0.303837264067494 1528 753451
SGTC_232 clozapine 119 µM 0.513183525490566 0.32387117372047 no 1110 0.303911474452828 1463 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2560 caryophyllene 100 µM 0.512390109535954 0.324126957423172 no 1111 0.30418900580411 1477 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1564 D-Arginine 115 µM 0.511028330020129 0.324566165323565 no 1112 0.304665609747154 1381 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_887 0885-0007 9.62 µM 0.510951010635175 0.324591110084743 no 1113 0.304692680419613 1529 5719458
SGTC_372 0155-0182 15.9 µM 0.510155776842785 0.3248477138663 no 1114 0.304971165702367 1486 771486
SGTC_2435 5706476 10.6 µM 0.508751410901754 0.325301073658012 no 1115 0.305463240688726 1516 5725375
SGTC_676 falcarinol 140 µM 0.507253418781144 0.325784943143236 no 1116 0.305988508933644 1585 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3059 1327-0034 3 µM 0.505460249301306 0.326364544553306 no 1117 0.306617805565098 1428 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1832 st054113 55 µM 0.505095172630673 0.326482598763135 no 1118 0.306745995889392 1483 1251267
SGTC_2046 4110841 106 µM 0.505057389191679 0.326494817720989 no 1119 0.306759264237093 1477 44119630 YMR134W ERG29
SGTC_2924 9010168 62.78 µM 0.503812726656237 0.326897438799587 no 1120 0.307196491788043 1488 2993929
SGTC_706 4262-0057 46.9 µM 0.501196015093294 0.327744544728032 no 1121 0.308116589259748 1431 883298
SGTC_2284 7945075 39.21 µM 0.500662896642706 0.327917239672808 no 1122 0.308304194492866 1588 1245402
SGTC_29 0299-0004 12.984 µM 0.499685188058144 0.328234047887621 no 1123 0.308648381816788 1418 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3049 9092223 49.47 µM 0.499236120105471 0.328379601404491 no 1124 0.308806525689669 1476 8623917
SGTC_1655 st012546 55.1 µM 0.496989015382747 0.329108332036239 no 1125 0.309598398764725 1461 720985 YLR208W SEC13
SGTC_663 1486-0733 13.9 µM 0.496639424116232 0.329221762125161 no 1126 0.309721673309654 1478 722445 YPR165W RHO1
SGTC_2780 5215298 71.43 µM 0.495655497029973 0.3295410962805 no 1127 0.310068745250245 1539 2834131
SGTC_2031 5180455 200 µM 0.494767064836919 0.329829544342789 no 1128 0.310382277637721 1456 29949
SGTC_1916 st067606 49.2 µM 0.494745330522916 0.329836602110811 no 1129 0.310389949519448 1589 19590279
SGTC_1495 4469-0029 237 µM 0.490262268462164 0.331293675460301 no 1130 0.311974161554433 1468 793680
SGTC_1315 1237-0019 3.69 µM 0.490005911797819 0.33137707336349 no 1131 0.31206485775322 1560 825140
SGTC_643 k048-0106 28.4 µM 0.489397140788932 0.33157515213908 no 1132 0.312280279958492 1560 6763920
SGTC_1748 st037455 53.6035 µM 0.488624315994763 0.331826677749262 no 1133 0.312553847369695 1539 580690
SGTC_962 1254-0300 21.5 µM 0.488338188827412 0.331919820695857 no 1134 0.312655157949923 1515 7340576
SGTC_1011 4112-3381 17.4 µM 0.484564919126131 0.333149102730664 no 1135 0.313992501708713 1538 2877139
SGTC_604 1000-0114 314 µM 0.484392104885248 0.333205446436203 no 1136 0.314053810240678 1603 1572745
SGTC_790 1575-0012 79.1 µM 0.482696743175186 0.333758395246842 no 1137 0.314655538029703 1546 378741 YLR208W SEC13
SGTC_1251 0490-5699 265 µM 0.482322074228559 0.333880643758495 no 1138 0.314788584254757 1605 3883818
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.480629233824621 0.334433210282778 no 1139 0.315390017219175 1475 688669
SGTC_350 k064-0020 19.8 µM 0.47972395665085 0.33472885263528 no 1140 0.315711845407137 1594 2790705
SGTC_1985 st071382 65.5 µM 0.478239872251554 0.335213741540626 no 1141 0.316239743286047 1507 6123237
SGTC_1474 0330-0125 5.35 µM 0.477071313020868 0.335595733542688 no 1142 0.316655670730422 1495 X1474
SGTC_140 0062-0056 502.533 µM 0.475801730325409 0.336010941904275 no 1143 0.317107818510961 1423 3758964
SGTC_2414 st077232 92.9 µM 0.474404267567324 0.336468204022714 no 1144 0.317605825210441 1456 729801
SGTC_251 melphalan 456.522 µM 0.474055514081818 0.336582356986774 no 1145 0.31773016024275 1607 460612 A DNA alkylator.
SGTC_2375 9072683 200 µM 0.473033700964915 0.336916900525269 no 1146 0.318094567863845 1647 16798029
SGTC_1505 k297-0037 20.6 µM 0.471449454790469 0.337435840795283 no 1147 0.31865990333266 1492 4089396
SGTC_1435 4092-0789 56.7 µM 0.468947893904448 0.338255888944761 no 1148 0.319553440594941 1607 2248285
SGTC_1808 st050063 61.5 µM 0.468934670286439 0.338260225883201 no 1149 0.319558166754677 1577 4011993
SGTC_647 0140-0236 81 µM 0.468653937991548 0.338352302471412 no 1150 0.319658508211965 1559 990837
SGTC_3287 9117173 37.0625 µM 0.46565350252003 0.339337009594798 no 1151 0.32073176989066 1522 2789709
SGTC_332 4112-0506 40.9 µM 0.463980192761174 0.339886647345686 no 1152 0.321330968349396 1564 2790355
SGTC_406 estrone 100 µM 0.463916772156272 0.339907486032941 no 1153 0.321353687908239 1648 5870 A steroid.
SGTC_1211 1056-0033 32.3 µM 0.463332018681571 0.340099646863424 no 1154 0.321563199278926 1566 6741922
SGTC_783 0848-0141 92.7 µM 0.461446612163258 0.340719509088496 no 1155 0.322239108073082 1492 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1330 1469-0054 61.8 µM 0.461412191800659 0.340730829423681 no 1156 0.322251453074597 1669 7102664
SGTC_2495 cafestol 54.53 µM 0.460970438376801 0.340876128155324 no 1157 0.322409907118536 1570 16667697 An anti-infammatory.
SGTC_11 0438-0307 1.3 µM 0.458690856374922 0.341626288616059 no 1158 0.323228090551022 1629 4011476
SGTC_2880 9042983 58.44 µM 0.458675663948678 0.341631290213424 no 1159 0.323233546264098 1543 6464714
SGTC_1707 st032323 6.317 µM 0.458419945945386 0.341715480971269 no 1160 0.323325382202568 1544 3132057 YMR211W DML1
SGTC_2387 9077560 195.08 µM 0.458006538226713 0.341851605010867 no 1161 0.323473871976257 1495 5303272
SGTC_583 1488-1091 88.9 µM 0.457507146043554 0.342016068844213 no 1162 0.323653283560661 1612 4303273
SGTC_2767 sibutramine 71.45 µM 0.456033468651872 0.342501566750221 no 1163 0.324182955599969 1653 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2216 7189485 200 µM 0.455452129035081 0.342693158722261 no 1164 0.32439199982461 1617 731273
SGTC_2822 7994718 71.43 µM 0.453182016196257 0.34344170651989 no 1165 0.325208840540064 1575 1018011
SGTC_1862 st057513 3.81 µM 0.453096629271426 0.343469874043186 no 1166 0.325239581219105 1530 5393163
SGTC_3160 9100216 49.47 µM 0.452928324583774 0.343525397105556 no 1167 0.325300177121133 1560 17191039
SGTC_292 k038-0015 474 µM 0.45128683166724 0.344067096131565 no 1168 0.325891417204926 1572 46368540
SGTC_3289 9119912 71.43 µM 0.451014770804185 0.344156908229783 no 1169 0.325989451634985 1561 17014829
SGTC_2463 5473429 200 µM 0.450809805202128 0.344224576803411 no 1170 0.326063316899947 1555 5399405
SGTC_366 0181-0206 4.31 µM 0.447324853690415 0.345375881396854 no 1171 0.327320262260226 1722 274874
SGTC_394 menadione 8.33 µM 0.44495478956215 0.346159685614264 no 1172 0.328176213319886 1570 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2452 5863136 48.41 µM 0.443743512210157 0.346560522169867 no 1173 0.328614016337771 1519 2184096
SGTC_1200 1643-0193 18.4 µM 0.443342432224856 0.346693285672633 no 1174 0.328759034232875 1573 5403974
SGTC_3336 9143619 71.43 µM 0.442604786227527 0.34693750673433 no 1175 0.329025811117363 1597 45595730
SGTC_1359 1582-0056 520 nM 0.442509407077086 0.346969089667334 no 1176 0.329060312281975 1605 3661189
SGTC_484 loperamide 105 µM 0.441216776558443 0.347397223643973 no 1177 0.329528034466871 1559 3955 An opioid-receptor agonist.
SGTC_3002 9075603 71.4286 µM 0.437760276511058 0.348543011378789 no 1178 0.330780034767471 1552 20105405
SGTC_246 cycloheximide 667 µM 0.437473682892787 0.348638075915736 no 1179 0.330883928897659 1527 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_78 0336-0123 156.75 µM 0.436041848062433 0.34911316496289 no 1180 0.331403183706453 1518 6765896
SGTC_3286 9117135 37.221 µM 0.434747019405146 0.349542998505082 no 1181 0.331873032491091 1508 3438150
SGTC_1801 st050089 28.441 µM 0.434687915099195 0.349562623481417 no 1182 0.331894485729505 1571 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2182 6325192 200 µM 0.433066588058643 0.350101125067147 no 1183 0.332483197610099 1561 736248
SGTC_2957 9076800 11.52 µM 0.431262057598492 0.35070082975052 no 1184 0.333138917735329 1531 16459615
SGTC_1626 st003712 1.76 µM 0.431072788478199 0.350763751682624 no 1185 0.333207722893213 1618 24207035
SGTC_2965 9082772 38.63 µM 0.428357776539419 0.351666798763118 no 1186 0.334195330277121 1727 16459634
SGTC_925 2064-1272 59.6 µM 0.428223800372323 0.351711382647847 no 1187 0.334244094987002 1564 6815817
SGTC_1928 4'-methoxychalcone 40.3 µM 0.426322134415583 0.352344428714727 no 1188 0.334936565633615 1750 641818
SGTC_2280 7785178 200 µM 0.424866995693884 0.352829106740283 no 1189 0.335466817728445 1601 2954328
SGTC_3346 9158254 43.5805 µM 0.424842838411335 0.352837155073356 no 1190 0.335475623404378 1578 17639500
SGTC_2300 7976697 71.57 µM 0.420512963299245 0.354280773526364 no 1191 0.337055380692909 1526 2236109
SGTC_2739 tacrine 100.86 µM 0.419687918048206 0.354556089298703 no 1192 0.337356726205225 1598 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1913 st060213 96.1 µM 0.41966661724765 0.354563198335717 no 1193 0.337364507646844 1723 688959
SGTC_2482 5981709 142.65 µM 0.418940003780795 0.354805732317344 no 1194 0.337629990025812 1621 877755
SGTC_3121 9125696 49.47 µM 0.418788678687555 0.354856250044267 no 1195 0.337685289768515 1653 1235365
SGTC_3254 9136651 49.47 µM 0.418474566453095 0.354961120085844 no 1196 0.337800089093314 1561 16454030
SGTC_1992 st073643 23.3 µM 0.41818957596667 0.355056277000053 no 1197 0.337904258283068 1599 3161292
SGTC_2803 7707263 71.43 µM 0.41815351740548 0.355068317419764 no 1198 0.337917439225906 1571 2199229
SGTC_949 1165-0505 146 µM 0.416925778779145 0.355478361498725 no 1199 0.33836634857719 1585 6244267
SGTC_2156 5649887 115 µM 0.416711253676234 0.355550026466999 no 1200 0.338444810966184 1698 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1309 pyrazolanthrone 13.4 µM 0.414074934878649 0.356431140193268 no 1201 0.339409614360383 1697 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3026 9090633 49.47 µM 0.413627753185983 0.35658067401485 no 1202 0.339573372400904 1581 25236842
SGTC_1914 st062367 72.6 µM 0.412827644376064 0.356848278717797 no 1203 0.339866448004937 1601 978205
SGTC_2090 5301565 104.445 µM 0.40965130619865 0.357911331970503 no 1204 0.341030877404491 1618 2056344
SGTC_1687 st020778 55.3625 µM 0.406654351252903 0.358915360924756 no 1205 0.342130936106898 1645 4259299
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.406200106650546 0.359067625603201 no 1206 0.342297787864317 1503 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_510 ag-490 170 µM 0.403447300736489 0.359990855824314 no 1207 0.343309597869307 1729 5328779
SGTC_1854 st056233 32.9 µM 0.403231370833532 0.360063308577699 no 1208 0.343389011814656 1736 5393174
SGTC_2322 7413319 38.22 µM 0.402088159819618 0.360446983373083 no 1209 0.34380957311091 1651 1840400
SGTC_1418 3966-3099 2.4 µM 0.401785201181249 0.360548683360532 no 1210 0.343921057124548 1686 740335
SGTC_1555 citronellol 128 µM 0.399392905022193 0.361352097683887 no 1211 0.344801860477038 1740 8842 A terpine precursor.
SGTC_2354 9060492 162 µM 0.399383916323947 0.361355117550044 no 1212 0.344805171555492 1733 6471895
SGTC_2707 st078556 66.6 µM 0.39780429348869 0.361885945689737 no 1213 0.345387226083906 1748 17250899
SGTC_1725 st036284 20.55 µM 0.397717595575982 0.361915088001967 no 1214 0.345419182864729 1783 707914
SGTC_2481 5478948 45.16 µM 0.393288978596242 0.363404768374057 no 1215 0.347053028781005 1622 77792
SGTC_1689 st020265 53.493 µM 0.392979730055083 0.363508869661622 no 1216 0.347167226285743 1728 5758320 YPR016C TIF6
SGTC_1340 1486-1359 257 µM 0.392868475665771 0.363546323315162 no 1217 0.347208313055495 1645 4309068
SGTC_196 k015-0023 18.111 µM 0.388393745017265 0.365053813516473 no 1218 0.348862336196201 1638 5211998
SGTC_1416 3966-0321 25.3 µM 0.387400671423549 0.365388653617248 no 1219 0.349229803403788 1655 582530 YLR208W SEC13
SGTC_2813 7971799 71.43 µM 0.38684539743449 0.365575923162518 no 1220 0.349435333196451 1676 2234054
SGTC_3047 9092122 49.47 µM 0.384981595768384 0.36620473573227 no 1221 0.350125525539966 1604 17173831
SGTC_1058 3448-5425 97.3 µM 0.3842330080692 0.366457396799988 no 1222 0.350402877807486 1646 7279705
SGTC_1947 st076332 61.6 µM 0.384010689266448 0.366532444327628 no 1223 0.35048526245211 1720 24208416
SGTC_2466 5983409 37.09 µM 0.383257679419164 0.366786673627723 no 1224 0.350764357433246 1644 2879657
SGTC_2992 9074591 71.4286 µM 0.383025974205974 0.366864913125743 no 1225 0.350850252686294 1653 17741321
SGTC_1548 st061468 90.8 µM 0.380548409795909 0.367701853160619 no 1226 0.351769184370229 1735 390799
SGTC_2896 9052656 71.43 µM 0.378899280815537 0.368259290176372 no 1227 0.352381329140517 1651 6469436
SGTC_737 1950-0117 57.9 µM 0.378525793145672 0.368385574700164 no 1228 0.35252001825761 1740 5393513
SGTC_771 0250-0039 27.3 µM 0.377647405475945 0.368682633216042 no 1229 0.352846271773226 1672 3005115
SGTC_2027 5150920 200 µM 0.376715986139475 0.368997712040015 no 1230 0.353192340715712 1721 786715
SGTC_451 chloral hydrate 100 µM 0.376385870951022 0.369109403945167 no 1231 0.353315024208735 1703 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2690 usnic acid 100 µM 0.375246482357335 0.369494992060422 no 1232 0.353738581843859 1798 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_734 2023-0417 80 µM 0.374160982115007 0.369862465601266 no 1233 0.35414227545165 1724 3935732
SGTC_2836 9010338 19.48 µM 0.372961238070165 0.370268752287666 no 1234 0.354588646690889 1533 2994051
SGTC_2016 5121758 140 µM 0.372555636035837 0.37040613994347 no 1235 0.354739598328164 1637 2795203
SGTC_1957 st077035 62.4 µM 0.370520790004663 0.371095642892593 no 1236 0.355497244459078 1702 705593
SGTC_258 haloperidol 50.781 µM 0.3703455625265 0.371155037717059 no 1237 0.355562514693335 1616 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_101 0490-5701 117.494 µM 0.369582386963131 0.371413758255137 no 1238 0.355846838250517 1762 4661669
SGTC_2157 5649910 96.377 µM 0.369008214700198 0.371608443989177 no 1239 0.356060800887503 1621 2858091
SGTC_286 k060-0067 22.9 µM 0.36819512344857 0.371884196640083 no 1240 0.356363873127112 1665 5985051
SGTC_2131 toluylene red 5.2905 µM 0.367092537360963 0.372258233869553 no 1241 0.35677499681716 1604 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2624 nerol 100 µM 0.366088670398798 0.372598886841355 no 1242 0.357149455652784 1762 637566 A natural product oil.
SGTC_1429 4049-0205 9.46 µM 0.365597188833073 0.372765702931013 no 1243 0.357332836544675 1699 22774478
SGTC_2824 7998404 51.95 µM 0.363724155746918 0.373401656505962 no 1244 0.358032001711285 1703 837851
SGTC_3122 9126309 49.47 µM 0.361253647117937 0.374240999168176 no 1245 0.358954920712965 1751 17591206
SGTC_2933 9026794 32.47 µM 0.359862609775537 0.374713859716878 no 1246 0.359474939714303 1738 17586027
SGTC_2662 daunorubicin 22.37 µM 0.359030336095504 0.374996867786048 no 1247 0.359786197632451 1673 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3029 9088683 49.47 µM 0.358540787976583 0.37516336619864 no 1248 0.359969324774639 1701 25236615
SGTC_3267 9137951 49.47 µM 0.357572650200354 0.375492704447713 no 1249 0.360331574395172 1730 16643986
SGTC_521 r062-0005 13.8 µM 0.356922666400223 0.375713864951603 no 1250 0.360574850235871 1658 2832033
SGTC_2888 9058547 12.99 µM 0.356850444269186 0.375738441444723 no 1251 0.360601885010403 1642 16476514
SGTC_1459 k035-0031 35.7 µM 0.356435860543457 0.375879530029863 no 1252 0.360757088833026 1586 3877128 YMR208W ERG12
SGTC_1436 4092-1007 8.32 µM 0.355755008031092 0.376111269568824 no 1253 0.361012022958006 1696 2881121
SGTC_1662 st014054 52 µM 0.351570177639543 0.377536624921582 no 1254 0.362580316933918 1708 2838777
SGTC_549 1661-1316 519 µM 0.351524842856947 0.37755207514697 no 1255 0.36259731914172 1815 2857282
SGTC_3315 9136395 68.55 µM 0.351375612689479 0.377602934604782 no 1256 0.362653287846809 1846 16876844
SGTC_3256 9138902 49.47 µM 0.350181145579696 0.378010099947439 no 1257 0.36310137784932 1770 17228773
SGTC_2794 7785382 27.27 µM 0.349343143039944 0.37829583595433 no 1258 0.363415856375171 1871 2205081
SGTC_942 3253-1115 227 µM 0.348303212692116 0.378650516385415 no 1259 0.363806240675403 1794 46497897
SGTC_1464 k208-0027 110 µM 0.346932309877005 0.37911823503736 no 1260 0.364321086319164 1808 X1464
SGTC_145 3737-0113 38.366 µM 0.346850164707521 0.379146266596755 no 1261 0.364351943908967 1842 6849351
SGTC_2903 5923464 63.88 µM 0.345515633920504 0.379601756363912 no 1262 0.364853379486827 1771 2876576
SGTC_74 000s-0487 160.283 µM 0.343990462444019 0.380122518481085 no 1263 0.365426729386553 1703 677548
SGTC_702 1488-0190 94 µM 0.342224777792725 0.380725674103567 no 1264 0.366090869891723 1855 949357
SGTC_22 0964-0034 14.468 µM 0.342061008547277 0.380781632187368 no 1265 0.366152490045159 1696 138402
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.341952605515351 0.380818673639136 no 1266 0.366193279891928 1715 3256 An antibiotic and ribosome inhibitor.
SGTC_1738 st035555 74 µM 0.34039875740918 0.381349745379276 no 1267 0.366778127162656 1725 5331140
SGTC_1052 3253-3998 198 µM 0.339746779017632 0.381572644139143 no 1268 0.367023615177549 1682 5450317
SGTC_675 1309-0189 238 µM 0.336525577718978 0.382674485472559 no 1269 0.368237283458272 1711 4246530
SGTC_2871 9038510 12.99 µM 0.33622639376865 0.382776872444099 no 1270 0.368350075486441 1865 4945164
SGTC_2788 5282734 71.43 µM 0.335717940287013 0.382950894591507 no 1271 0.368541787925959 1846 743706
SGTC_2694 st077685 81.9 µM 0.334077941297894 0.383512357818426 no 1272 0.369160372520599 1679 2838096
SGTC_877 0771-0151 33.1 µM 0.333746333347776 0.383625915515422 no 1273 0.369285491635528 1754 6166523
SGTC_104 0074-0074 590.992 µM 0.332698448330369 0.383984824831568 no 1274 0.369680960471626 1819 3943124
SGTC_401 neomycin 50 µM 0.332654846426017 0.383999761004551 no 1275 0.36969741869771 1760 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_506 n9-isopropylolomoucine 153 µM 0.331921399823152 0.384251034678037 no 1276 0.369974305438808 1904 6610355
SGTC_724 3910-0327 137 µM 0.326635034781371 0.386063539374987 no 1277 0.371971970898212 1688 2885483
SGTC_2529 gangaleoidin 93.61 µM 0.324827525734236 0.38668384248649 no 1278 0.372655805358352 1737 4565183
SGTC_1067 clotrimazole 1.36 µM 0.321982460715505 0.387660801465736 no 1279 0.373732990933693 1737 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3009 9080819 71.4286 µM 0.321819509713546 0.387716778364101 no 1280 0.373794716665915 1723 17027216
SGTC_1413 3910-0535 34.4 µM 0.321119585062762 0.387957242879249 no 1281 0.374059884457407 1819 2876951
SGTC_2287 7945887 168.79 µM 0.320480159310089 0.388176960092985 no 1282 0.374302184228874 1868 1245853
SGTC_3281 9140613 49.47 µM 0.318815764579151 0.388749041208804 no 1283 0.374933111606339 1656 16013766
SGTC_1690 st023502 41.2 µM 0.31765565969335 0.389147932042364 no 1284 0.375373074385696 1857 24207482
SGTC_7 0192-1582 4.227 µM 0.316363320429817 0.389592427972219 no 1285 0.375863377173008 1779 252616
SGTC_2983 9022671 12.99 µM 0.31345237218021 0.390594167619834 no 1286 0.376968500083483 1907 6405161
SGTC_1513 0337-0559 19 µM 0.31181259645541 0.391158781221645 no 1287 0.377591475207647 1684 775073
SGTC_3232 9132874 49.47 µM 0.311429778098316 0.391290627725526 no 1288 0.377736959509875 1707 3784940
SGTC_2916 7875993 68.79 µM 0.311270965024332 0.391345328217297 no 1289 0.377797319098239 1922 1299250
SGTC_3184 9108758 49.47 µM 0.309458788786638 0.391969653748326 no 1290 0.378486278198357 1768 902885
SGTC_128 0906-2981 13.371 µM 0.307556770741728 0.392625230598248 no 1291 0.379209809302031 1866 6740226
SGTC_2508 celastrol 40.54 µM 0.307275593900195 0.392722170947519 no 1292 0.379316805458175 1784 122724 Celastrol is a natural product and antioxidant.
SGTC_1493 4348-0038 111 µM 0.305632689729781 0.393288722094545 no 1293 0.379942163957825 1820 800424
SGTC_686 1319-0111 510 µM 0.304929693096846 0.393531217749525 no 1294 0.380209850117266 1864 4562600
SGTC_36 0335-0881 14.2 µM 0.304243926702079 0.393767809706136 no 1295 0.380471030665527 1795 23828853
SGTC_2586 curcumin 80 µM 0.304189438426444 0.393786610046926 no 1296 0.380491785373771 1855 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2556 citropten 84.59 µM 0.302428142794596 0.394394451097515 no 1297 0.381162851854973 1683 2775 A potential DNA crosslinker.
SGTC_1031 k035-0009 16 µM 0.300907150353517 0.39491956813286 no 1298 0.381742648840447 1913 5180959
SGTC_441 propafenone 146 µM 0.299283723912181 0.395480260776762 no 1299 0.382361786112922 1770 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.297538235513022 0.396083352118097 no 1300 0.383027810625228 1893 1241132 A phosphatase inhibitor.
SGTC_1230 0170-0365 3.77 µM 0.29736063321056 0.396144730237318 no 1301 0.383095597607687 1889 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_520 3584-0023 682 µM 0.297208735785233 0.396197226972637 no 1302 0.3831535764313 1729 1340790
SGTC_3073 9114972 49.47 µM 0.293465705022361 0.397491435116696 no 1303 0.384583104752772 1922 41905075
SGTC_2875 9039966 71.43 µM 0.293311343269842 0.397544832313684 no 1304 0.384642092039583 1894 6463691
SGTC_888 0916-0002 6.97 µM 0.292597807961696 0.397791685135631 no 1305 0.384914794735889 1867 2802138 YIL048W NEO1
SGTC_2886 9058944 51.95 µM 0.291925288649449 0.398024385638812 no 1306 0.385171873849197 1781 4949929
SGTC_1762 st045503 25.4615 µM 0.291251889149101 0.398257427049126 no 1307 0.385429340000874 1763 4645554
SGTC_2159 5658611 73.75 µM 0.29052251501311 0.398509880382386 no 1308 0.385708264346603 1890 793844
SGTC_824 1304-0008 100 µM 0.28998284585697 0.398696699763458 no 1309 0.3859146805271 1801 768245
SGTC_2852 9023854 51.95 µM 0.289872943056951 0.398734748091825 no 1310 0.385956720828414 1854 19798528
SGTC_2172 5754775 163.918 µM 0.289793392911599 0.398762288937398 no 1311 0.385987151389913 1744 2263357
SGTC_3142 9086498 49.47 µM 0.288920851815491 0.399064402143785 no 1312 0.386320973224116 1941 25236367
SGTC_252 miconazole 1.30953 nM 0.288462128143088 0.399223257299555 no 1313 0.386496508158327 1847 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2513 baicalein 25.65 µM 0.287758982318946 0.399466787781827 no 1314 0.386765618611898 1710 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1381 2324-0066 62.1 µM 0.287113543460702 0.399690366231514 no 1315 0.387012691190527 1816 10885928
SGTC_170 4197-0004 226 µM 0.287067698504949 0.399706248064663 no 1316 0.387030242281835 1865 218692
SGTC_2616 abietic acid 100 µM 0.28695054724687 0.399746832928535 no 1317 0.387075093029194 1981 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.285318649924969 0.400312285697051 no 1318 0.387700012927434 1829 165521
SGTC_994 3910-0338 138 µM 0.285065198846728 0.400400125331969 no 1319 0.387797095809372 1883 3479481
SGTC_908 3448-7491 47.7 µM 0.283973734122254 0.400778456485367 no 1320 0.388215254755795 1751 1203031
SGTC_2264 7948757 110.76 µM 0.283415083109125 0.400972136054178 no 1321 0.388429333769248 1747 2971411
SGTC_2059 5238311 157 µM 0.283301888915043 0.401011382488618 no 1322 0.388472714715833 1780 703021
SGTC_2163 5671233 125 µM 0.282602964527367 0.401253734081255 no 1323 0.388740603785166 1906 701023
SGTC_1155 4088-0394 48.2 µM 0.28140949713879 0.401667655938474 no 1324 0.389198167332464 1773 2326248
SGTC_2097 5376186 200 µM 0.279624012277289 0.402287108925232 no 1325 0.38988299128936 1911 742755
SGTC_2915 7971052 15.16 µM 0.279133297633747 0.402457399671915 no 1326 0.39007126522861 1894 5741558
SGTC_3230 9131665 49.47 µM 0.276834246705912 0.403255476177986 no 1327 0.390953691686474 1844 15943720
SGTC_2627 acetyl isogambogic acid 100 µM 0.274745202821015 0.403981001981095 no 1328 0.391756000093685 1735 6857789 A caspase activator and apoptosis inducer.
SGTC_88 0180-0332 8.668 µM 0.273116258393696 0.404546964481909 no 1329 0.392381924642863 1830 3101745
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.273073441333108 0.404561843595099 no 1330 0.392398380931684 1885 616764
SGTC_1850 st056238 17 µM 0.272454048385833 0.404777100744434 no 1331 0.392636459634435 1904 5393177
SGTC_2540 epiandrosterone 100 µM 0.27117079273329 0.405223161219679 no 1332 0.393129837831307 1866 441302 A steroid.
SGTC_1370 2001-0092 44.6 µM 0.271050013239649 0.40526515059741 no 1333 0.393176283237263 1953 790957
SGTC_216 k038-0035 28.382 µM 0.269010614428755 0.405974318410317 no 1334 0.393960757264177 1934 4444231 YPR107C YTH1
SGTC_1819 st053448 58.6 µM 0.268940837051954 0.405998587833628 no 1335 0.393987605425492 1861 2857616
SGTC_2493 resveratrol 26.09 µM 0.268439067391393 0.406173120079414 no 1336 0.394180685593847 1801 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2408 sulbentine 18.36 µM 0.2682549246972 0.406237175737381 no 1337 0.394251549936272 1871 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_217 ketoconazole 989 nM 0.266652372249453 0.406794743502608 no 1338 0.39486841392341 1868 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2245 6637752 200 µM 0.266452509900534 0.406864293850732 no 1339 0.394945364644991 1960 681890
SGTC_792 4534-1957 155 µM 0.264769780447956 0.407449985244755 no 1340 0.395593409001305 1860 1717904
SGTC_727 3032-0951 202 µM 0.263654315358029 0.407838348558439 no 1341 0.396023150616583 1864 3652836
SGTC_1308 1187-1617 41.4 µM 0.262752842291576 0.408152274033682 no 1342 0.396370542517167 1821 2882570
SGTC_545 4218-0007 221 µM 0.262382234926228 0.408281350016067 no 1343 0.396513383755645 1852 2840508
SGTC_1394 3474-0001 65.7 µM 0.260886737480162 0.408802306263787 no 1344 0.397089926365421 1825 5017666 YIL048W NEO1
SGTC_1720 st037298 9.481 µM 0.260567202535014 0.408913637127839 no 1345 0.397213142355059 1808 597396
SGTC_1218 1348-1416 30.7 µM 0.259400158636836 0.409320315451764 no 1346 0.397663253663666 1815 6787668
SGTC_1102 cgs 12066b 26.1 µM 0.25912756819759 0.409415318778416 no 1347 0.397768407357914 1867 6438352 A 5-HT1B full agonist.
SGTC_1455 4262-0120 131 µM 0.256709017674749 0.410258465333984 no 1348 0.398701704843604 1926 1529587
SGTC_677 0929-0063 136 µM 0.256095331287192 0.410472472684147 no 1349 0.398938613450726 1847 1539583
SGTC_266 formosanin C 406 nM 0.255522833907644 0.410672140464329 no 1350 0.399159654951207 1941 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1006 4099-6547 255 µM 0.255447544419779 0.410698400622413 no 1351 0.399188726664432 1911 3146833
SGTC_2597 laccaic acid a 100 µM 0.255042485194515 0.410839687761138 no 1352 0.399345142761188 1845 5491415 A textile dye.
SGTC_2010 4012422 159 µM 0.254172296006929 0.411143254179401 no 1353 0.39968122625434 1883 952393
SGTC_139 0099-0334 718.624 µM 0.252570615918965 0.411702140963757 no 1354 0.400300019517503 2002 97690
SGTC_846 0335-0850 148 µM 0.250398326224662 0.412460421146639 no 1355 0.401139661938509 1913 6819598
SGTC_1651 st011928 86.1 µM 0.250173325550692 0.412538980759264 no 1356 0.401226656305134 1899 720198
SGTC_1758 st042942 75.2445 µM 0.248364844442931 0.413170543983422 no 1357 0.401926065803729 1992 669317
SGTC_3071 9117417 49.47 µM 0.248355692775488 0.41317374052927 no 1358 0.401929605907895 2002 45595590 YGL055W OLE1
SGTC_1316 1272-0050 65.9 µM 0.248254781540288 0.413208987754357 no 1359 0.401968641544656 1869 7340392
SGTC_1283 0922-0125 16.4 µM 0.247032775252386 0.413635877049582 no 1360 0.402441429491772 1929 3360884
SGTC_2724 maprotiline 69.64 µM 0.246848063472918 0.413700412192802 no 1361 0.402512905964407 1930 4011 A tricyclic antidepressant.
SGTC_3005 9076496 71.4286 µM 0.246808853103529 0.413714111926646 no 1362 0.402528079313805 1973 21368410
SGTC_698 k064-0052 127 µM 0.246786464946843 0.41372193418488 no 1363 0.402536742989036 1913 5088751
SGTC_3016 9080866 49.47 µM 0.245640709281178 0.414122298479476 no 1364 0.402980186542503 1851 17066299
SGTC_2135 5326629 150.42 µM 0.245442693203168 0.414191500795584 no 1365 0.403056837671251 1823 5020077
SGTC_2931 9014674 55.67 µM 0.244120403915054 0.414653680360805 no 1366 0.403568785241342 1838 2996810
SGTC_1079 idarubicin 2.36 µM 0.243648703311652 0.414818582428858 no 1367 0.403751452472732 1986 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2061 5245884 80.95 µM 0.243205738430409 0.41497345242803 no 1368 0.403923010840446 1853 573863
SGTC_2670 beta-carotene 100 µM 0.242980765448506 0.415052112856965 no 1369 0.404010148975158 1947 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2250 alverine citrate 130 µM 0.242752563679436 0.41513190569078 no 1370 0.404098542573144 1821 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1772 st048439 82.2 µM 0.242039214291432 0.415381357383978 no 1371 0.404374888900671 1852 2927068 YDL195W SEC31
SGTC_99 0109-0120 622.8 µM 0.241683853313974 0.415505636570944 no 1372 0.404512570954862 1955 759414
SGTC_2585 alliin 100 µM 0.240975268697857 0.415753472680701 no 1373 0.404787142248909 1926 87310 A garlic compound which reacts with lipids.
SGTC_1171 0368-0077 21.4 µM 0.240400351834173 0.415954581495194 no 1374 0.405009952738626 1857 3239779
SGTC_2737 bleomycin 30.5 nM 0.236606337443636 0.41728229636107 no 1375 0.406481101613267 1917 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2123 5259487 200 µM 0.23599079057945 0.417497796288025 no 1376 0.406719908215568 1964 2173474
SGTC_2630 antimycin a 100 µM 0.235470807517021 0.417679859110781 no 1377 0.406921667069156 1865 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3219 9131112 49.47 µM 0.235335920943873 0.417727090129878 no 1378 0.406974008504516 1976 17612988 YMR079W SEC14
SGTC_403 arphamenine a 50 µM 0.234436545373512 0.418042040029246 no 1379 0.407323044960622 1908 5487158 An arginine aminopeptidase inhibitor.
SGTC_3014 9081533 49.47 µM 0.233794282341003 0.418266984568873 no 1380 0.407572344306025 2009 21367265
SGTC_284 0988-0104 32.6 µM 0.233762942524029 0.418277961629845 no 1381 0.407584510056235 1973 4666532
SGTC_2244 6635614 200 µM 0.233185855995424 0.418480102896453 no 1382 0.407808544212668 1883 836499
SGTC_577 r071-0003 38.6 µM 0.233042662781109 0.418530263802028 no 1383 0.407864138764308 1890 4568517 YMR134W ERG29
SGTC_1177 0983-0204 23.6 µM 0.232061692893762 0.418873935347887 no 1384 0.408245048691031 2037 766818
SGTC_309 k408-0051 1.48 µM 0.231252428696053 0.419157498398372 no 1385 0.408559350714248 1921 3640463
SGTC_580 1123-0028 41 µM 0.229921421385634 0.419623969495846 no 1386 0.409076415171726 1970 1677248 YPR107C YTH1
SGTC_1857 st056007 79.3 µM 0.229908479133924 0.41962850585402 no 1387 0.40908144370482 2009 619834
SGTC_2317 5986382 200 µM 0.229245983109522 0.419860730029207 no 1388 0.409338867350341 1968 877883
SGTC_2968 9090663 33.37 µM 0.22884241523308 0.420002206021369 no 1389 0.409495699407084 1883 25236811
SGTC_856 0433-0016 11.3 µM 0.228268511174393 0.420203413387988 no 1390 0.409718751398826 1903 3911780
SGTC_297 0986-0032 24 µM 0.22777767938889 0.420375512655311 no 1391 0.409909539933169 1897 2847425
SGTC_634 1611-4317 11.2 µM 0.226370289627968 0.420869066920756 no 1392 0.410456716819559 2050 2843522
SGTC_146 3448-8650 53.125 µM 0.225858203380302 0.421048680172179 no 1393 0.410655853354266 1915 2891488 YIL048W NEO1
SGTC_2346 9031566 143.75 µM 0.224944465795577 0.421369212645559 no 1394 0.411011238449473 1990 4771086
SGTC_429 1112-0049 25.5 µM 0.224874949807781 0.421393600482441 no 1395 0.411038278687249 1840 2836170
SGTC_2719 novobiocin 32.65 µM 0.223287089212473 0.421950741104916 no 1396 0.411656037473025 2009 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_285 1486-1325 46 µM 0.223244399736527 0.421965721937466 no 1397 0.411672648887786 1999 22310230
SGTC_186 3455-3465 67.277 µM 0.221459206718794 0.422592292811344 no 1398 0.412367448169056 1938 755278
SGTC_3112 9123419 49.47 µM 0.221070866766384 0.422728619198869 no 1399 0.412518627004178 2040 17015854
SGTC_789 1309-1135 70.6 µM 0.220723685249228 0.422850504791281 no 1400 0.412653794052181 1913 3092424
SGTC_2417 cerulenin 830 nM 0.220692516244581 0.422861447707035 no 1401 0.412665929486075 2027 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_568 1193-0097 7.48 µM 0.219824141258987 0.423166343527278 no 1402 0.413004058730934 1993 3646150
SGTC_2942 9052777 62.25 µM 0.219647192982301 0.423228477625293 no 1403 0.413072967059627 1917 6469503
SGTC_1044 1222-0021 1.78 µM 0.219621441388633 0.423237520268967 no 1404 0.413082995633095 1958 4306703
SGTC_2483 5729050 27.16 µM 0.219568357651646 0.423256160692161 no 1405 0.413103668480438 2031 2865180
SGTC_905 2-aminofluorene 215 µM 0.219194468691639 0.423387457149783 no 1406 0.413249282033257 1936 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2698 st077697 67.5 µM 0.21606218224784 0.424487737168873 no 1407 0.414469638820355 1841 3154499
SGTC_3241 9133421 49.47 µM 0.21586240633988 0.424557932625424 no 1408 0.414547500809307 2028 17018221
SGTC_15 0266-0086 27.098 µM 0.212926561133763 0.425589778244399 no 1409 0.415692122307958 2052 1712902 YIL048W NEO1
SGTC_2099 5377090 177.372 µM 0.212462670536821 0.425752866183255 no 1410 0.415873048777012 1906 2243829
SGTC_1860 st056228 74.6 µM 0.211026545489048 0.426257838642964 no 1411 0.41643327872544 1897 688679
SGTC_205 1486-1330 71.903 µM 0.207617741424962 0.427456930181069 no 1412 0.417763725277634 1952 4118834
SGTC_1433 4060-0023 7.6 µM 0.203998101110201 0.428730919879305 no 1413 0.419177491402495 2005 3840627
SGTC_1295 1013-0063 9.78 µM 0.203688034826359 0.428840087350195 no 1414 0.419298646504348 2075 6826038
SGTC_2939 9044578 71.43 µM 0.203531638359399 0.428895153148244 no 1415 0.419359759663952 1920 2653634
SGTC_1571 st070080 73.4 µM 0.202982571300853 0.429088485703469 no 1416 0.419574327364789 2004 4315245
SGTC_1236 0330-0013 258 µM 0.20177718426087 0.42951297535755 no 1417 0.420045459497224 1927 4617066
SGTC_2808 7946468 45.46 µM 0.201021916049567 0.429778992527403 no 1418 0.420340718659692 1967 2970879
SGTC_2399 5884133 200 µM 0.200847323839953 0.42984049115113 no 1419 0.42040897887712 1898 722445
SGTC_1372 2752-0194 270 µM 0.200831061422001 0.429846219536494 no 1420 0.420415337107362 1969 823334
SGTC_2908 7930301 100 µM 0.199421923668853 0.430342639814309 no 1421 0.420966356142226 1993 2223178
SGTC_2985 9022375 71.43 µM 0.199278525482846 0.430393163252572 no 1422 0.421022438230989 1961 4939335
SGTC_1269 0831-0796 3.05 µM 0.199191812950526 0.430423715205035 no 1423 0.421056351710519 2046 927758
SGTC_758 0868-0029 16 µM 0.199093209991858 0.430458457089612 no 1424 0.421094916276087 2069 762687
SGTC_1034 k072-0165 12.7 µM 0.199008931819254 0.43048815218859 no 1425 0.421127878880139 2059 5835461
SGTC_1409 3909-8004 61.9 µM 0.198560609671967 0.430646123424063 no 1426 0.421303234463792 1961 2119279
SGTC_260 nsc-65238 3.989 µM 0.197134051806837 0.431148860490879 no 1427 0.421861318378814 2014 3246252
SGTC_615 k087-0205 167 µM 0.194135936565792 0.432205796994045 no 1428 0.423034721783868 1926 9642773
SGTC_2843 9000894 45.46 µM 0.192279316976899 0.432860561714728 no 1429 0.423761709385233 2014 2242070
SGTC_2390 9097792 176.6 µM 0.191579278886822 0.433107488600627 no 1430 0.424035887450181 1884 4497149
SGTC_2405 ticlatone 3.52 µM 0.191207683124543 0.433238573492586 no 1431 0.424181442204163 1943 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3206 9114350 49.47 µM 0.191173511412058 0.433250628345783 no 1432 0.424194827847315 2078 17087243
SGTC_3313 9133968 57.047 µM 0.19077691655922 0.433390540791831 no 1433 0.424350187214619 2005 1494643
SGTC_2076 5212012 200 µM 0.18927543302675 0.433920316128726 no 1434 0.424938474449122 2031 604802
SGTC_1786 berberine 21.6 µM 0.188742381767018 0.434108423659873 no 1435 0.425147366342899 1994 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1227 3909-8010 46.6 µM 0.188551781863676 0.434175687751816 no 1436 0.42522206365349 1984 15982272
SGTC_711 k292-0785 179 µM 0.188409134608906 0.434226030252422 no 1437 0.425277969773601 2009 4146315
SGTC_749 1000-0129 128 µM 0.187153971348783 0.434669043365509 no 1438 0.425769956323492 2081 708470
SGTC_2191 5911152 200 µM 0.186456222509361 0.434915351135654 no 1439 0.426043503085688 1989 2875902
SGTC_2829 7992743 58.44 µM 0.184720111026759 0.435528313949212 no 1440 0.426724285654504 2137 16462845
SGTC_718 1130-0073 349 µM 0.184662122353883 0.435548790489294 no 1441 0.426747028571557 2026 6740020
SGTC_3094 9117742 49.47 µM 0.184114086092333 0.435742317609937 no 1442 0.426961978137519 2092 17149698
SGTC_852 0418-0143 439 µM 0.183782720745896 0.435859339563928 no 1443 0.427091956044168 2081 5369229
SGTC_1259 0671-0132 43 µM 0.181627814527116 0.436620483086241 no 1444 0.4279374095325 1942 X1259
SGTC_1866 st057638 64 µM 0.18135577487881 0.436716588102799 no 1445 0.42804416486986 1969 688802
SGTC_733 4069-0007 56.1 µM 0.181162740145142 0.43678478486315 no 1446 0.428119919846919 2033 5717425 YNL287W SEC21
SGTC_3046 9092212 49.47 µM 0.18083021008901 0.436902267983276 no 1447 0.428250424887444 2048 25236637
SGTC_2714 st079313 56.9 µM 0.179800664001701 0.437266042636348 no 1448 0.428654531157395 1975 2939799
SGTC_2425 5628681 7.85 µM 0.179340324127422 0.437428713998514 no 1449 0.42883524300326 2039 5714958
SGTC_425 3825-7017 13.1 µM 0.178564876599787 0.437702759580554 no 1450 0.429139687789173 2023 3397440
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.177954491108458 0.437918492749278 no 1451 0.429379358011522 2047 688751
SGTC_3087 9117406 49.47 µM 0.175451967399643 0.438803170905676 no 1452 0.43036225486429 1989 42546093
SGTC_3258 9138477 49.47 µM 0.174883295558716 0.439004247389959 no 1453 0.430585668102432 2057 4970355
SGTC_2566 crystal violet carbinol 226 nM 0.173669429908285 0.439433510334551 no 1454 0.431062631894597 1825 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.173489332633981 0.439497204752873 no 1455 0.431133406034785 2008 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_722 3534-0461 190 µM 0.172798191917549 0.439741652771077 no 1456 0.4314050291531 1951 658262
SGTC_2936 9038235 15.59 µM 0.172712015657687 0.439772133873034 no 1457 0.431438899301073 2057 4749415
SGTC_963 1269-2853 151 µM 0.171297376653861 0.440272551765624 no 1458 0.431994971552649 1955 3668223
SGTC_2302 7771753 200 µM 0.171248376234987 0.440289887009094 no 1459 0.432014235264558 1942 2203047
SGTC_352 k048-0007 5.11 µM 0.169393092620686 0.440946328432593 no 1460 0.432743728143539 2097 6811911
SGTC_3105 9121040 49.47 µM 0.16875117144804 0.441173492585503 no 1461 0.432996183460194 2124 41448907
SGTC_2037 5169046 200 µM 0.168476283058125 0.441270776478307 no 1462 0.433104300174288 2034 5718022
SGTC_1146 3579-1023 7 µM 0.168376387877313 0.441306130584988 no 1463 0.433143591320078 2115 X1146
SGTC_1392 3455-1037 33.9 µM 0.168075639223577 0.441412571975447 no 1464 0.433261886892762 2074 981132
SGTC_1648 st011736 69.8 µM 0.1675370233755 0.441603210231535 no 1465 0.433473759371257 2098 2855514
SGTC_1591 genipin 88.4 µM 0.167373061580549 0.441661245728627 no 1466 0.433538259957523 2095 442424 A DNA cross-linking agent.
SGTC_2699 st077704 54.6 µM 0.167053025255498 0.441774528573856 no 1467 0.433664163473429 2019 645852
SGTC_1893 st059353 36.1 µM 0.167005042697279 0.441791513308886 no 1468 0.433683040576163 1963 3112488
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.166995935863284 0.441794736933219 no 1469 0.433686623366803 2106 688798
SGTC_2722 naftopidil 47.16 µM 0.166673969031591 0.441908708776943 no 1470 0.433813294350462 2085 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3191 9110352 49.47 µM 0.165971849947427 0.442157265972209 no 1471 0.434089551688887 2055 17122424
SGTC_2057 5236571 38.335 µM 0.16573205250047 0.4422421618949 no 1472 0.434183910308509 2092 54684039 YBR257W POP4
SGTC_2679 rapamycin 1 nM 0.164516194029141 0.44267265520587 no 1473 0.434662399721807 2034 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3095 9117207 49.47 µM 0.163993188682002 0.442857854110093 no 1474 0.434868252931787 2126 17015229
SGTC_2511 berberine 10.47 µM 0.163984428289823 0.442860956316804 no 1475 0.434871701144269 1992 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3166 9102297 49.47 µM 0.160552591158896 0.44407649692124 no 1476 0.436222898566625 1976 25237072
SGTC_1206 3978-0017 132 µM 0.160419164886754 0.444123766582245 no 1477 0.436275446862293 2032 3873677
SGTC_2313 7726885 200 µM 0.160238860280756 0.444187645351734 no 1478 0.436346459399762 2017 726423
SGTC_3222 9128301 49.47 µM 0.158387958418081 0.444843471064062 no 1479 0.437075550900174 2045 4911358
SGTC_2946 9065502 71.43 µM 0.158331678720508 0.444863414891922 no 1480 0.437097723480592 2148 16489101
SGTC_2773 thioridazine 9.09 µM 0.155543984217864 0.445851463438314 no 1481 0.438196240735678 2161 5452 An antipsychotic.
SGTC_1137 ixabepilone 100 µM 0.155433081846399 0.445890777801386 no 1482 0.438239952767952 2022 154225 A novel microtubule stabilizer.
SGTC_2259 7964009 200 µM 0.153937011876647 0.446421179328315 no 1483 0.438829700323021 2092 313134
SGTC_1945 st075991 56.6 µM 0.153809139260239 0.446466518454263 no 1484 0.438880113752047 1953 1084980
SGTC_654 1124-0271 80.9 µM 0.152289779208822 0.447005283411198 no 1485 0.439479192952657 1978 5403748
SGTC_2902 5787006 60.46 µM 0.149423345835001 0.448021986031668 no 1486 0.440609795604824 2027 591003
SGTC_1708 st033234 31.827 µM 0.149039467429564 0.448158170929341 no 1487 0.44076124511517 2105 674664
SGTC_1304 1165-0502 251 µM 0.149014346466209 0.448167083068213 no 1488 0.440771156257858 2070 767425
SGTC_3187 9109394 49.47 µM 0.148218236036133 0.448449531892122 no 1489 0.441085270248462 2000 17098090
SGTC_1100 amiodarone 5.07 µM 0.145589910277757 0.44938220982631 no 1490 0.442122566771505 2174 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1882 5615643 20 µM 0.145257782816896 0.449500087359807 no 1491 0.442253672780932 2172 2253075
SGTC_1059 3448-6867 171 µM 0.144127568676362 0.449901252392085 no 1492 0.442699867670244 2189 3934407
SGTC_653 0203-0016 55.2 µM 0.143948101676939 0.449964958213921 no 1493 0.442770725775534 2083 295302
SGTC_880 0833-0487 87.2 µM 0.143933625645462 0.449970096860996 no 1494 0.442776441358285 2091 76075
SGTC_891 0929-0073 133 µM 0.143154504289797 0.450246678775652 no 1495 0.443084079986887 2118 5603632
SGTC_2442 5158906 48.48 µM 0.143022393932307 0.450293579306865 no 1496 0.443136247603388 2113 1893835
SGTC_2692 st077426 47.7 µM 0.141874866859377 0.450700992313867 no 1497 0.443589423408756 2138 25238571
SGTC_1614 st002383 48.6 µM 0.140491485943921 0.451192210865186 no 1498 0.444135839503981 2194 1947235
SGTC_1834 st055981 52.8 µM 0.140479111378321 0.451196605232871 no 1499 0.444140727764959 2153 471719 YDL150W RPC53
SGTC_3207 9114163 49.47 µM 0.140036425449559 0.451353812640032 no 1500 0.444315605293529 2171 849233
SGTC_2693 st077581 40.7 µM 0.139633449334774 0.451496924862714 no 1501 0.44447480538484 2196 25238761
SGTC_378 3970-0959 8.33 µM 0.139366045159068 0.451591893788088 no 1502 0.444580451255122 2084 6615653
SGTC_1658 st012944 20 µM 0.139068939838786 0.451697414360808 no 1503 0.444697836051677 2129 24207260
SGTC_2255 7941087 197.44 µM 0.138728353008995 0.451818382119184 no 1504 0.444832406137145 2173 935561
SGTC_742 0kpi-0133 140 µM 0.137138319179709 0.452383180609937 no 1505 0.445460732132159 2144 2728852
SGTC_3250 9135583 49.47 µM 0.135201583324769 0.453071261758972 no 1506 0.446226247638648 2167 7699353
SGTC_2179 6298986 200 µM 0.133117936985813 0.453811694401057 no 1507 0.447050054865057 2167 738374
SGTC_148 3253-0744 288.01 µM 0.132787364093733 0.45392917971693 no 1508 0.447180773925636 2212 6893655
SGTC_2035 5154463 94.595 µM 0.132701455680625 0.453959712151984 no 1509 0.447214745790982 2149 2769623
SGTC_331 k048-0133 24.5 µM 0.130191186425699 0.454851998332501 no 1510 0.448207583723093 2115 6813582
SGTC_3216 9129716 49.47 µM 0.129853293646048 0.4549721212959 no 1511 0.448341248793418 2093 8056934
SGTC_2895 9054447 58.44 µM 0.128686799035646 0.455386848886617 no 1512 0.44880274069684 2062 2697450
SGTC_3323 9138564 53.9225 µM 0.128141249069007 0.455580826741099 no 1513 0.449018596535825 2171 43912313 YNL103W MET4
SGTC_357 1325-0123 420 µM 0.127202462642722 0.455914650035394 no 1514 0.449390078154615 2176 1098503
SGTC_621 3584-0052 32.1 µM 0.126847391991484 0.456040917819626 no 1515 0.449530592640072 2181 2273927
SGTC_614 0462-0418 107 µM 0.125914733245447 0.456372604625958 no 1516 0.44989971002829 2146 5188303
SGTC_946 3434-1334 87.4 µM 0.124739900338146 0.456790460466134 no 1517 0.450364734090965 2138 4047976
SGTC_1272 0839-0021 27 µM 0.124722266470262 0.456796732714385 no 1518 0.450371714474826 2125 5027250
SGTC_2174 5790901 200 µM 0.123881116105855 0.457095936717939 no 1519 0.450704702463383 2087 786020
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.123764782053363 0.457137319601866 no 1520 0.450750758609515 2205 4000243
SGTC_1288 0973-0013 65.5 µM 0.123487949959622 0.457235797454992 no 1521 0.450860357898494 2113 4315430
SGTC_254 nsc-64875 3.808 µM 0.123007189476703 0.457406825264914 no 1522 0.451050702413131 2178 56993
SGTC_1355 1499-0035 1.68 µM 0.120857136472126 0.458171790483043 no 1523 0.451902096684571 2106 1548538
SGTC_359 0081-0058 15.9 µM 0.119009229042083 0.458829379557343 no 1524 0.452634022015167 2171 3494159
SGTC_2474 5321570 43.32 µM 0.118371037366451 0.459056510206281 no 1525 0.45288683662343 2172 2841384
SGTC_3204 9114183 49.47 µM 0.118104562446331 0.459151351851801 no 1526 0.452992404223432 2085 17027248
SGTC_50 0929-0078 56.389 µM 0.117795481690245 0.4592613603413 no 1527 0.453114854855879 2136 1377751
SGTC_2827 7993847 71.43 µM 0.115080746518229 0.460227726077152 no 1528 0.454190560277757 2123 2985692
SGTC_1486 3970-0793 4.53 µM 0.114563080712198 0.460412026701913 no 1529 0.454395722150729 2213 2844330
SGTC_2214 7179297 48.276 µM 0.114371059765673 0.460480392625556 no 1530 0.454471827196927 2163 769744
SGTC_1332 1480-0653 17.5 µM 0.113865753869445 0.460660304118596 no 1531 0.454672106705128 2228 5749438
SGTC_1757 st041620 31.8375 µM 0.113431771629419 0.460814827630695 no 1532 0.454844126068819 2085 5289815
SGTC_2768 sulfasalazine 50.2 µM 0.113373137792635 0.460835705221257 no 1533 0.454867367659089 2199 5384001 An antioxidant and salicylic acid derivative.
SGTC_3180 9109287 49.47 µM 0.11240115111931 0.461181813553038 no 1534 0.455252671325777 2136 18891271
SGTC_1557 sumaresinolic acid 42.3 µM 0.111628010320388 0.461457137177106 no 1535 0.455559180898461 2155 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_315 k915-0449 187 µM 0.111236842450494 0.461596443243026 no 1536 0.455714268428939 2126 20970215 YNL149C PGA2
SGTC_2799 7812892 81.82 µM 0.1109251131196 0.461707462347808 no 1537 0.455837865550089 2171 20205235
SGTC_2617 dihydrotanshinone i 20.83 µM 0.110770597968046 0.461762492391684 no 1538 0.455899130628797 2149 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1778 st046819 58.9 µM 0.110318100918118 0.461923651878789 no 1539 0.456078551211781 2176 671715
SGTC_1291 0993-0025 5.79 µM 0.110241227272718 0.461951031501969 no 1540 0.456109033438082 2179 4353356
SGTC_1622 st003707 19.4 µM 0.110215209035168 0.461960298301746 no 1541 0.456119350345776 2131 10140899
SGTC_1885 st057546 99.9 µM 0.110159265406801 0.461980223564603 no 1542 0.456141533549211 2193 702008
SGTC_14 0354-0009 295 µM 0.109855853800833 0.462088290364933 no 1543 0.456261847062986 2163 1713507
SGTC_1239 0337-0584 35.4 µM 0.109353250797489 0.462267309771612 no 1544 0.456461155882394 2201 914301 YML130C ERO1
SGTC_857 0438-0306 1.35 µM 0.107177365404707 0.463042414169908 no 1545 0.457324135887016 2134 4686136
SGTC_3257 9139206 32.98 µM 0.10629057960439 0.463358349706618 no 1546 0.457675902818314 2199 4910041
SGTC_1761 st044296 37 µM 0.104751094420754 0.463906877490177 no 1547 0.458286658729585 2201 1826700
SGTC_556 4058-0063 51.5 µM 0.104702896619663 0.463924051768289 no 1548 0.458305781714198 2127 6615692
SGTC_3084 9116877 49.47 µM 0.102641691645979 0.46465858153614 no 1549 0.459123676209015 2241 27241325
SGTC_1476 4112-3294 3.34 µM 0.101253806333631 0.465153235526798 no 1550 0.45967449243495 2178 704369
SGTC_1311 1190-0148 100 µM 0.100967297611301 0.465255356374657 no 1551 0.459788210101995 2212 1961333
SGTC_1029 k015-0030 64.7 µM 0.100644549241468 0.465370396929275 no 1552 0.459916315522706 2136 2208316
SGTC_3146 9095609 49.47 µM 0.100155975638948 0.465544549797994 no 1553 0.460110248278856 2154 17173999
SGTC_473 2-arachidonoylglycerol 10 µM 0.100119775626309 0.465557453615368 no 1554 0.460124617767833 2068 5282280 An endocannabinoid.
SGTC_3223 9129970 49.47 µM 0.096734845918436 0.466764200170516 no 1555 0.461468483273145 2202 17248386
SGTC_488 nitrendipine 139 µM 0.0952051468264392 0.467309647452791 no 1556 0.462075940991416 2256 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2451 5856223 45.7 µM 0.0941730975995588 0.467677681660728 no 1557 0.462485827393512 2164 2179896
SGTC_3036 9090181 49.47 µM 0.0928046040641715 0.468165736245009 no 1558 0.463029396642471 2221 25236586
SGTC_2607 solasodine 47.35 µM 0.0921131723304379 0.468412344199714 no 1559 0.463304061470807 2144 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_721 1187-1332 279 µM 0.0918574908660656 0.468503539332944 no 1560 0.463405632993094 2224 25730
SGTC_633 0437-0093 97.7 µM 0.0908191685051769 0.468873899679519 no 1561 0.463818139364773 2229 2831118
SGTC_2081 5214970 32.255 µM 0.0891614105880868 0.469465262880846 no 1562 0.46447681653957 2238 2063512
SGTC_827 3253-0474 693 µM 0.0877502417806162 0.469968714785199 no 1563 0.46503759321841 2240 5402065
SGTC_2388 9080168 200 µM 0.0876969644794214 0.469987723066129 no 1564 0.465058766162048 2228 15943073
SGTC_3237 9133362 49.47 µM 0.0871328539701998 0.470188990658236 no 1565 0.465282955497211 2255 43845137
SGTC_1706 st031321 9.9705 µM 0.086833513104466 0.470295794840987 no 1566 0.465401924308556 2250 6103185
SGTC_3325 9138760 55.175 µM 0.0860259678573631 0.470583935900564 no 1567 0.465722887188262 2157 43844959
SGTC_2137 5261020 140 µM 0.0859702838679156 0.47060380513211 no 1568 0.465745019891314 2235 763655
SGTC_221 trifluoperazine 10.304 µM 0.085874479004305 0.470637990515966 no 1569 0.465783099677334 2242 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_928 2764-0428 58.7 µM 0.081855631429055 0.47207219980454 no 1570 0.467380758486729 2176 662578
SGTC_3304 9125678 46.087 µM 0.0814875200790734 0.47220358638015 no 1571 0.467527124703028 2220 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2897 9048598 12.99 µM 0.0808042976106623 0.472447450655535 no 1572 0.467798795124858 2225 6467404
SGTC_1439 4092-1168 46 µM 0.0804241036333263 0.472583158705372 no 1573 0.467949978533314 2238 2886240
SGTC_1305 1181-0477 144 µM 0.0796792984607273 0.472849021830707 no 1574 0.468246162265114 2259 6252086
SGTC_703 3875-0075 71.8 µM 0.0782811180656616 0.473348144130747 no 1575 0.468802218483657 2198 2850814
SGTC_512 prima-1 270 µM 0.0766028688880063 0.473947300546837 no 1576 0.46946973830971 2246 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2471 5466956 24.79 µM 0.0738362903202419 0.474935132494811 no 1577 0.470570325162147 2189 724419
SGTC_1442 4112-3290 3 µM 0.0726553337079917 0.475356851039203 no 1578 0.471040196548822 2277 704353
SGTC_1676 st018489 23.4 µM 0.0718715923841018 0.475636739631908 no 1579 0.471352048780493 2121 3696235
SGTC_1596 piperlongumine 63 µM 0.0717492355222352 0.475680436629757 no 1580 0.471400736409368 2278 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2068 5226020 147 µM 0.0715240448077138 0.475760859186506 no 1581 0.471490344285902 2237 1810509
SGTC_455 paf C-16 10 µM 0.0709540700837366 0.475964419163286 no 1582 0.471717155035517 2264 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_973 1325-0077 65.9 µM 0.070799303443522 0.476019693390155 no 1583 0.471778743103418 2236 2835149
SGTC_380 3970-0968 6 µM 0.0693173999540529 0.476548971932328 no 1584 0.472368487944929 2251 2891601
SGTC_2049 5262831 67.185 µM 0.0686385163333422 0.476791456748424 no 1585 0.472638679773557 2220 763417
SGTC_837 0091-0265 12.5 µM 0.0678179598414154 0.477084555986579 no 1586 0.472965273395405 2195 759367
SGTC_470 aa-861 153 µM 0.0675828028550938 0.477168555339747 no 1587 0.473058872714769 2199 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_490 phenamil 164 µM 0.0675238573225289 0.477189611163397 no 1588 0.473082334984349 2280 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2610 ononetin 44.17 µM 0.0669518604890912 0.477393936382825 no 1589 0.473310013461053 2223 259632
SGTC_447 ml7 120 µM 0.0656236953265696 0.477868398268888 no 1590 0.47383871181537 2293 4216 Selective myosin light chain kinase inhibitor.
SGTC_3017 9080681 49.47 µM 0.0649110552416724 0.478122988436159 no 1591 0.474122409174694 2198 16451914
SGTC_3177 9107506 49.47 µM 0.0646701804600707 0.478209042805791 no 1592 0.47421830282541 2282 8897194
SGTC_874 0599-0792 117 µM 0.0645057636300081 0.478267782567425 no 1593 0.474283758979326 2285 765305
SGTC_858 0438-0351 2.77 µM 0.0633573549626304 0.478678077572591 no 1594 0.47474097239998 2197 2799119
SGTC_2356 9061756 188.97 µM 0.0618508105874663 0.4792163588681 no 1595 0.475340819956785 2277 20104043
SGTC_326 k292-0812 17.5 µM 0.0611711221829298 0.479459220840609 no 1596 0.47561146390496 2301 3579357
SGTC_3015 9080845 49.47 µM 0.0603922001229338 0.479737549728804 no 1597 0.475921635360184 2275 5296973
SGTC_2215 7188065 200 µM 0.0603146855150785 0.479765248234839 no 1598 0.475952502945197 2286 940217
SGTC_396 dithiazanine 1.25 µM 0.0601086922398802 0.479838856847645 no 1599 0.476034533538347 2201 10578 An antihelmenthic.
SGTC_870 0573-2213 57.6 µM 0.0594834880895404 0.480062268389981 no 1600 0.476283508391824 2303 3916321
SGTC_1182 1222-0449 220 µM 0.0590919953800742 0.480202168271476 no 1601 0.476439417131731 2242 658318
SGTC_1484 3473-2379 286 µM 0.0590370842730906 0.480221790945601 no 1602 0.47646128531579 2308 671917
SGTC_3354 9151612 71.43 µM 0.0578717646412494 0.480638233175124 no 1603 0.476925386984118 2290 27261949
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0575540056711498 0.480751792189768 no 1604 0.477051943530312 2287 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3128 9127691 49.47 µM 0.0569622246205517 0.480963283917905 no 1605 0.47728764332194 2245 41316314
SGTC_4 0960-0234 25.671 µM 0.0569144584689871 0.480980354901681 no 1606 0.477306668394958 2208 6821112
SGTC_2275 7947463 200 µM 0.056872922947693 0.480995199169875 no 1607 0.477323211874133 2311 1225414
SGTC_2018 5133068 143 µM 0.0561902222218902 0.481239191506391 no 1608 0.477595135197086 2305 785362
SGTC_144 4161-2749 112.381 µM 0.0557353402850322 0.481401766950945 no 1609 0.477776322885689 2278 797501 YMR168C CEP3
SGTC_3076 9116187 49.47 µM 0.0545813661065917 0.481814212761346 no 1610 0.478235992159365 2295 27241210
SGTC_1344 1488-0097 29.1 µM 0.0540891348945836 0.481990148730144 no 1611 0.478432074337237 2261 747966
SGTC_2984 9022109 38.96 µM 0.0536694518728395 0.482140156899947 no 1612 0.478599260792229 2314 6459207
SGTC_2986 9022445 71.43 µM 0.0522127707913533 0.482660840913139 no 1613 0.479179578597225 2312 6459286
SGTC_2132 5317594 122.667 µM 0.0510656784033513 0.483070884717884 no 1614 0.479636592480121 2278 794577
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0507180259879393 0.483195161366777 no 1615 0.479775106236649 2271 115019
SGTC_368 fentichlor 4.58 µM 0.0503153834099249 0.483339097600785 no 1616 0.479935532554212 2254 7329 A pesticide.
SGTC_1285 0929-0069 65.5 µM 0.0495081322114617 0.483627679409215 no 1617 0.480257178290555 2280 1206237
SGTC_2715 st079500 56.4 µM 0.0492521897819016 0.483719177298223 no 1618 0.480359160134671 2301 28246688
SGTC_3043 9092303 49.47 µM 0.0482649595828921 0.484072114183123 no 1619 0.480752540097068 2287 25236084
SGTC_1812 st052057 4.327 µM 0.0474967172406519 0.484346771094481 no 1620 0.481058673323617 2314 3645418
SGTC_195 4234-0266 16.654 µM 0.0469454574605315 0.484543858422447 no 1621 0.481278349098094 2256 2303354
SGTC_3212 9128307 49.47 µM 0.0460736686415423 0.484855549522696 no 1622 0.481625766547108 2146 27243542
SGTC_1458 k015-0034 6.33 µM 0.0460395214248555 0.484867758384029 no 1623 0.481639374874885 2239 3598957
SGTC_1463 k081-0032 34.1 µM 0.045281583420694 0.485138752183243 no 1624 0.481941433340527 2298 977755
SGTC_1926 methyl fluorone black 53.6 µM 0.0430754098948605 0.485927587956797 no 1625 0.482820710580837 2325 72721 Reacts with homocysteine.
SGTC_610 4215-0184 155 µM 0.0428895276290673 0.485994054272148 no 1626 0.482894798405758 2284 5605015
SGTC_20 0481-0013 4.944 µM 0.0425717506961632 0.486107683343041 no 1627 0.483021457372916 2314 182045
SGTC_2420 aureobasidin a 50 nM 0.0411777248601138 0.486606165265892 no 1628 0.483577105797319 2310 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2603 homopterocarpin 100 µM 0.0406046057677228 0.486811109840294 no 1629 0.483805556157508 2296 101795 A weak amylase inhibitor.
SGTC_2396 5342950 42.78 µM 0.0405343420610484 0.486836236037713 no 1630 0.483833564262365 2284 1886677
SGTC_1423 4048-0112 5.59 µM 0.0383924967261469 0.487602181361033 no 1631 0.484687371659174 2338 X1423
SGTC_896 0964-0007 44.5 µM 0.037742670580772 0.487834574864855 no 1632 0.484946427007048 2347 6756758
SGTC_1402 3909-7673 35.9 µM 0.0372986794975279 0.487993359165715 no 1633 0.485123429185036 2334 5328014
SGTC_2064 5220758 200 µM 0.0329824633437856 0.489537060681708 no 1634 0.486844286128569 2299 788518
SGTC_1063 disulfiram 1.84 µM 0.032580119030002 0.489680968103088 no 1635 0.487004712064472 2346 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2520 obtusaquinone 4.71 µM 0.0320818534184791 0.48985918577674 no 1636 0.487203387417639 2337 5967872
SGTC_2849 9019321 12.99 µM 0.0318729280775306 0.489933913971043 no 1637 0.487286693965847 2312 16489627
SGTC_2002 4023503 131 µM 0.0317442381818766 0.489979943812414 no 1638 0.487338007840352 2361 4736863 YCR052W RSC6
SGTC_2522 biochanin a 4.94 µM 0.0317292315857445 0.489985311385024 no 1639 0.487343991591797 2336 5280373 A possible chelator.
SGTC_2766 oltipraz 83.91 µM 0.0305828727069026 0.490395347334082 no 1640 0.487801100680414 2342 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2248 tofa 1.1 µM 0.0298435906197483 0.49065978322817 no 1641 0.488095896973872 2339 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2266 7929956 200 µM 0.0298098460306323 0.490671853524242 no 1642 0.488109353130351 2355 2967153
SGTC_1967 st070177 51.4 µM 0.0298082062775837 0.490672440057154 no 1643 0.488110007006597 2333 5729214
SGTC_2969 9091408 28.7 µM 0.0295784546132528 0.490754621480085 no 1644 0.4882016242612 2226 4286311
SGTC_1703 st026983 48.3 µM 0.0284967211765217 0.491141559227578 no 1645 0.488632991545413 2359 1104023
SGTC_696 1560-0013 611 µM 0.0273629061275545 0.49154713559118 no 1646 0.489085141892519 2337 1650269
SGTC_2439 5492030 7.2 µM 0.0269662609738159 0.491689021397905 no 1647 0.489243322041137 2356 5722370
SGTC_965 1291-5240 308 µM 0.026052410417789 0.492015923158541 no 1648 0.489607767574611 2359 2834598
SGTC_817 1391-0715 46 µM 0.0257332181429936 0.492130105593432 no 1649 0.489735064188678 2333 1353946
SGTC_3309 9129340 25.759 µM 0.0244066075568053 0.492604671585969 no 1650 0.490264138914353 2318 17158987
SGTC_2778 tioconazole 65.09 nM 0.024132802878602 0.492702620560858 no 1651 0.490373339011539 2349 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1683 st010134 710 nM 0.023234925299605 0.493023824076003 no 1652 0.490731439880375 2366 3818134
SGTC_911 3456-4043 236 µM 0.0220073527470576 0.493462978770649 no 1653 0.491221045157675 2353 914281
SGTC_1213 1315-0166 115 µM 0.0214475545952093 0.493663244941569 no 1654 0.491444319597854 2296 768401
SGTC_3233 9132340 49.47 µM 0.0213954401595088 0.493681888812361 no 1655 0.491465105480006 2364 17682950
SGTC_1066 ketoconazole 628 nM 0.0213245867809014 0.493707236537448 no 1656 0.491493365440894 2361 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_597 k018-0003 82.8 µM 0.020745590567542 0.493914372794677 no 1657 0.491724300410248 2357 6786234
SGTC_995 3931-2021 34.6 µM 0.0207272699398626 0.493920927037756 no 1658 0.491731607711996 2334 730143
SGTC_1741 st038134 10.228 µM 0.0197490438686101 0.494270891810181 no 1659 0.492121783523185 2349 1272587
SGTC_457 grayanotoxin iii 135 µM 0.0189712176632257 0.494549165790233 no 1660 0.492432033126998 2338 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3089 9117425 49.47 µM 0.0188987650052361 0.494575086485659 no 1661 0.492460932374447 2289 9401657
SGTC_3034 9090421 49.47 µM 0.0174542035750812 0.495091898067639 no 1662 0.493037133763592 2364 17173761
SGTC_1826 st055655 41.6 µM 0.0173080607985131 0.495144183115355 no 1663 0.493095427490047 2311 676168
SGTC_2697 mebhydrolin 72.4 µM 0.0165594240188772 0.495412021861862 no 1664 0.493394047529173 2363 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2282 7944268 200 µM 0.0162823520778082 0.495511150038271 no 1665 0.493504568339097 2366 2970414
SGTC_2177 5811945 192 µM 0.015099270031351 0.495934424977653 no 1666 0.493976491663391 2366 5343475
SGTC_3333 9141820 12.094 µM 0.0150477351315322 0.495952862886353 no 1667 0.493997048778314 2367 1939433
SGTC_1320 1313-0481 95.3 µM 0.0135195317029763 0.496499619920412 no 1668 0.494606651490295 2367 6813365 YLR208W SEC13
SGTC_2810 7959871 45.46 µM 0.0125783144339188 0.496836369762081 no 1669 0.494982110873188 2374 2974535
SGTC_608 k048-0125 159 µM 0.0116904910254075 0.497154018354595 no 1670 0.495336275081553 2387 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2450 5739737 12.93 µM 0.0107140494312073 0.497503375150111 no 1671 0.495725794461022 2372 2262825
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0104955964269535 0.497581534772941 no 1672 0.495812939700113 2392 5355888
SGTC_2911 7942208 15.64 µM 0.00947497112249688 0.497946702316387 no 1673 0.496220089970691 2373 1243384
SGTC_3275 9138069 49.47 µM 0.00754714337856267 0.498636460503408 no 1674 0.496989153992717 2323 17617007
SGTC_3293 9120939 62.045 µM 0.00565415246263813 0.499313758387501 no 1675 0.497744331541567 2393 934087
SGTC_3307 9126885 69.2785 µM 0.00531632099237446 0.499434632205869 no 1676 0.497879104770533 2390 24824909
SGTC_890 0929-0006 47.2 µM 0.00423296512636256 0.499822249912835 no 1677 0.498311296282661 2396 1378169
SGTC_1713 st033146 12.748 µM 0.00377484125489369 0.499986163736326 no 1678 0.498494059798084 2397 674619
SGTC_656 4090-1979 187 µM 0.00369749912083727 0.499986163736326 no 1679 0.498524914630057 2401 22330961
SGTC_322 k048-0136 19.3 µM 0.00345296073913464 0.499898669448053 no 1680 0.49862247070596 2379 6823282
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.00339851927184227 0.499879190635467 no 1681 0.498644189581623 2396 6857784
SGTC_85 0868-0259 160.055 µM 0.00332753803925541 0.499853793999933 no 1682 0.498672506836277 2385 83173
SGTC_83 0170-0301 39.027 µM 0.00318833600401433 0.49980398839503 no 1683 0.498728040118888 2396 3089716
SGTC_2460 5552655 174.22 µM 0.00315901242606456 0.499793496605276 no 1684 0.49873973847503 2385 5401989
SGTC_1888 azatryptophan 97.5 µM 0.00280775215725793 0.499667817927541 no 1685 0.498879870423333 2371 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_843 0310-0051 143 µM 0.00247201492712035 0.499547693324407 no 1686 0.4990138097322 2396 2065037
SGTC_3050 9093513 49.47 µM 0.00172335116501621 0.499279826450407 no 1687 0.49931248269661 2404 25236664
SGTC_589 1227-0070 34.1 µM -0.000214073398207274 0.49858663073689 no 1688 0.499914597070998 2407 2841384
SGTC_1329 1447-1697 50.6 µM -0.000741999030127436 0.498397743629129 no 1689 0.499703985242028 2412 2840515
SGTC_2021 4019055 173 µM -0.00117163876903046 0.498244022605141 no 1690 0.499532583864616 2407 44827708 YER133W GLC7
SGTC_324 1315-0088 19.6 µM -0.00221305900615863 0.497871413447708 no 1691 0.499117117914092 2411 6787421
SGTC_3161 9100388 49.47 µM -0.00345833679259832 0.497425868678572 no 1692 0.498620325983737 2409 25236368
SGTC_421 streptovitacin 30 mM -0.00355616310087858 0.497390867781556 no 1693 0.498581299173275 2451 91467 include heat shock
SGTC_2051 5263410 176 µM -0.00440403962108375 0.497087510186278 no 1694 0.498243048070101 2414 227584
SGTC_2242 6630449 61.2675 µM -0.00471966152017736 0.496974585790695 no 1695 0.498117134460623 2458 691249 YDR170C SEC7
SGTC_850 0388-0143 75.9 µM -0.00520338581346315 0.49680151755895 no 1696 0.497924158765084 2418 67273
SGTC_1470 k295-0292 231 µM -0.00583076012645766 0.496577054722499 no 1697 0.497673876439185 2434 5045612
SGTC_2263 7948595 193.29 µM -0.00585186078194635 0.496569505319668 no 1698 0.497665458639179 2413 2971371
SGTC_3069 9117009 49.47 µM -0.00615495485358181 0.496461064311522 no 1699 0.497544543778487 2414 41904981
SGTC_1127 asiatic acid 681.4 nM -0.00741505492237488 0.496010228556228 no 1700 0.49704184818802 2430 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_883 0850-0245 24.6 µM -0.00759713576873585 0.49594508449021 no 1701 0.496969210486342 2464 6823229 YPR165W RHO1
SGTC_1421 4029-0249 71.4 µM -0.00865978872422091 0.495564895509598 no 1702 0.496545287317887 2423 2894095
SGTC_820 1582-0060 59.9 µM -0.00920361074048034 0.495370331984254 no 1703 0.496328342378853 2426 3848840
SGTC_67 0335-0847 266 µM -0.00938052815855257 0.495307036369809 no 1704 0.496257765587693 2428 4552207 YOR254C SEC63
SGTC_2667 digitoxin 100 µM -0.00954907233588603 0.495246736553407 no 1705 0.496190529200986 2427 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_442 cape 100 µM -0.0097280476049277 0.495182704938726 no 1706 0.49611913171567 2418 5281787
SGTC_2330 7979373 200 µM -0.00992889242362456 0.495110849248017 no 1707 0.496039010095747 2419 1863007
SGTC_1553 gossypol 38.6 µM -0.01032711419827 0.494968379025499 no 1708 0.495880150741738 2422 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3018 9082602 49.47 µM -0.0103610041274711 0.494956254389521 no 1709 0.495866631339405 2407 17332089
SGTC_413 propylparaben 100 µM -0.0123116523299498 0.494258388629129 no 1710 0.49508848542289 2428 7175 A pharmaceutical preservative.
SGTC_201 4262-0159 12.803 µM -0.0127758219811015 0.494092329360459 no 1711 0.494903323093217 2431 1341029
SGTC_932 2857-0803 154 µM -0.0135056601712019 0.493831227779019 no 1712 0.494612184925615 2474 674898
SGTC_305 1682-2595 20.8 µM -0.0141172719814136 0.493612424034586 no 1713 0.494368210390117 2443 226033
SGTC_2277 7947813 106.88 µM -0.014485738989759 0.493480606115103 no 1714 0.494221228354498 2480 1246798
SGTC_233 rapamycin 362 pM -0.0145667211514038 0.49345163509505 no 1715 0.494188924554682 2439 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1980 st071811 45.7 µM -0.0148133516870616 0.493363404295002 no 1716 0.494090543822334 2489 4974850
SGTC_2304 7443016 91.4 µM -0.0175691079016799 0.49237756982214 no 1717 0.49299130059763 2431 939854
SGTC_649 1123-0311 367 µM -0.0180954345130207 0.492189288713697 no 1718 0.49278136004363 2448 693629 YIL048W NEO1
SGTC_257 daunorubicin 18.5 µM -0.0188825167581773 0.491907731599493 no 1719 0.492467413330693 2504 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_786 4544-0069 423 µM -0.0191325370810166 0.491818294514406 no 1720 0.492367687669586 2513 748821 YLR208W SEC13
SGTC_2775 cyproheptadine 69.59 µM -0.0209863756346089 0.491155153888865 no 1721 0.491628261976065 2437 2913 A selective serotonin reuptake inhibitor.
SGTC_2894 9048625 32.47 µM -0.0211550974428447 0.491094801229592 no 1722 0.491560966653624 2445 4092861
SGTC_3279 9140807 49.47 µM -0.0220494192791073 0.490774901142786 no 1723 0.491204267110718 2443 45595718
SGTC_1012 4112-3522 18 µM -0.0222847998572407 0.490690706181089 no 1724 0.491110386914626 2450 3112398
SGTC_2853 9015042 58.44 µM -0.0239565052640118 0.490092754076722 no 1725 0.490443651255554 2451 6457456
SGTC_2866 9034245 58.44 µM -0.0255053769959235 0.489538758176637 no 1726 0.48982592983061 2464 6462273
SGTC_2028 5153890 36.43 µM -0.0257197383713151 0.489462087594028 no 1727 0.489740440060222 2447 2830968 YPR165W RHO1
SGTC_2763 lisinopril 49.32 µM -0.0283199308022744 0.488532109225446 no 1728 0.488703492246441 2449 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3055 9094636 49.47 µM -0.0283609310837845 0.488517445652593 no 1729 0.488687142068026 2467 25236176
SGTC_1037 k284-1091 78.7 µM -0.0284208028427809 0.488496032805555 no 1730 0.488663266316325 2437 3334711
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0295701872725528 0.488084967486086 no 1731 0.488204921010901 2454 88881 An O-methylated flavonoid and antioxidant.
SGTC_3344 9148862 3.898 µM -0.0296335238946855 0.488062316169603 no 1732 0.488179664422657 2491 4905352
SGTC_1521 st012942 49.4 µM -0.0299105870018523 0.487963229492988 no 1733 0.488069181210868 2544 24207259
SGTC_417 st075190 100 µM -0.0301403183473962 0.487881070739546 no 1734 0.487977572967196 2447 222757
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0302421075199314 0.487844668071968 no 1735 0.487936983465673 2497 7104
SGTC_2271 7849410 118.62 µM -0.0303572091220795 0.487803504627604 no 1736 0.487891085643587 2445 972430
SGTC_982 1491-0518 27.5 µM -0.0303741682893902 0.487797439581903 no 1737 0.487884323033242 2481 3091256
SGTC_598 3937-0236 20.2 µM -0.0310153886475143 0.487568124346307 no 1738 0.487628633605467 2481 1379313
SGTC_2378 9074213 121.43 µM -0.0312730036111 0.487475996428135 no 1739 0.487525909935769 2466 657714
SGTC_348 k064-0012 10.7 µM -0.0326560367408074 0.486981409520526 no 1740 0.486974441387168 2454 5066323
SGTC_1950 st077106 7.18 µM -0.0330371095889641 0.486845137427034 no 1741 0.486822497305192 2512 13831864
SGTC_247 mechlorethamine 29.705 µM -0.0343303309637256 0.486382691505785 no 1742 0.48630686925377 2461 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2402 5553605 200 µM -0.0344320696590588 0.486346311307214 no 1743 0.486266305368366 2487 6758546
SGTC_571 k831-0106 44.2 µM -0.0344618984946735 0.486335644994176 no 1744 0.4862544124428 2478 4783639
SGTC_56 0957-0365 83.25 µM -0.0351300186469676 0.486096738522974 no 1745 0.485988032380428 2462 6752360
SGTC_867 0518-0118 155 µM -0.0359420848404805 0.48580636653854 no 1746 0.485664269340553 2483 6848158
SGTC_1242 0402-0103 60.1 µM -0.0369108402299948 0.485459976770245 no 1747 0.485278048192363 2475 432868
SGTC_740 k014-0057 261 µM -0.0372419618219884 0.485341582892602 no 1748 0.485146040553932 2531 4012779
SGTC_540 1187-0821 17.3 µM -0.0394218283228399 0.484562195460022 no 1749 0.484277038474843 2477 847520
SGTC_611 3453-1652 23.7 µM -0.0398759756694481 0.484399827366446 no 1750 0.484096002251921 2476 1560575
SGTC_2863 9028737 58.44 µM -0.0414548313010756 0.483835370563479 no 1751 0.483466650637847 2498 6460917
SGTC_1447 4239-0816 81.9 µM -0.0420817555773387 0.483611247737459 no 1752 0.483216762113175 2486 1341554
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0436186198452069 0.483061847193117 no 1753 0.482604204666122 2631 6710655
SGTC_398 bronopol 33.3 µM -0.0465493361852801 0.482014260330296 no 1754 0.48143620604376 2502 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2524 avocatin b 10.57 µM -0.0486214604558291 0.481273652387343 no 1755 0.480610483609582 2514 6710748
SGTC_1634 st006576 41 µM -0.0545224261645916 0.479164922422396 no 1756 0.478259470833023 2519 3915356
SGTC_3192 9110362 49.47 µM -0.0547837458907025 0.479071551985696 no 1757 0.478155374927164 2496 16649480
SGTC_1179 1021-1431 9.29 µM -0.0559555233664999 0.478652886058695 no 1758 0.477688619412872 2564 2840958
SGTC_1874 staurosporine 7.6 µM -0.0561324460540203 0.478589675152525 no 1759 0.477618148231959 2550 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2860 9025725 38.96 µM -0.0571600420232923 0.478222546546336 no 1760 0.477208853968783 2528 40546248
SGTC_1727 st034309 9.9045 µM -0.057344461737565 0.478156660970448 no 1761 0.477135401628014 2680 870305
SGTC_3135 9127742 49.47 µM -0.0575273689335042 0.478091316344758 no 1762 0.477062552473886 2584 3643468
SGTC_3038 9091290 49.47 µM -0.0578174619356607 0.477987680194735 no 1763 0.476947014416345 2527 25236843
SGTC_2305 7443522 69.23 µM -0.0580905420377958 0.477890123288148 no 1764 0.476838254016399 2535 5415886
SGTC_2227 7312221 64.1025 µM -0.058660227967927 0.477686609263705 no 1765 0.476611369121095 2523 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2941 9056145 11.23 µM -0.059117503014082 0.477523256996808 no 1766 0.476429258816941 2505 2119517
SGTC_1018 4259-0013 28.1 µM -0.0612741465260773 0.47675289105856 no 1767 0.475570440093624 2648 6801262
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0643288874174048 0.475661868725256 no 1768 0.474354176125961 2600 6708760
SGTC_3147 9097027 49.47 µM -0.0662930075247666 0.474960465181053 no 1769 0.473572275083542 2560 25236841
SGTC_2611 pyromycin 23.93 µM -0.0681467551109495 0.474298547717594 no 1770 0.472834405819907 2559 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3299 9121982 43.1275 µM -0.0686958348528181 0.474102501406034 no 1771 0.472615866839697 2559 17594604 YPL160W CDC60
SGTC_2594 a-mangostin 100 µM -0.0689871878169154 0.473998477758999 no 1772 0.472499908921208 2610 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2811 7967822 32.47 µM -0.0701182916492566 0.473594649253778 no 1773 0.472049753951942 2594 2232244
SGTC_2820 7989630 71.43 µM -0.0726146323619335 0.472703498299129 no 1774 0.471056391259878 2539 2984098
SGTC_2620 irigenin 100 µM -0.0734719558158847 0.472397479773489 no 1775 0.470715279881022 2604 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1799 st045822 46.1415 µM -0.0736754312683641 0.472324852327598 no 1776 0.470634324326711 2535 3674992
SGTC_658 3253-0951 102 µM -0.0751025369735585 0.471815494801008 no 1777 0.470066564657396 2575 1184878
SGTC_1871 st057448 67.3 µM -0.0755032628782098 0.4716724773797 no 1778 0.469907150773934 2616 691747
SGTC_1159 4092-0538 61.2 µM -0.0770328484999198 0.471126608324589 no 1779 0.469298706636835 2539 717301
SGTC_1701 st028638 40.4 µM -0.0775435950962381 0.470944348267889 no 1780 0.469095555891572 2547 3490878
SGTC_507 nimesulide 162 µM -0.0795321275883331 0.470234798249323 no 1781 0.468304689209739 2660 4495 A COX2 inhibitor.
SGTC_898 1000-0849 28.3 µM -0.0796590463234528 0.470189514172182 no 1782 0.468254216098786 2510 6751807
SGTC_2339 9000433 200 µM -0.079892248922495 0.470106309459576 no 1783 0.46816147729437 2602 2988954
SGTC_1477 0139-0234 16 µM -0.0799299853577801 0.47009284554161 no 1784 0.468146470626089 2540 620880
SGTC_3218 9131285 49.47 µM -0.0802863515204832 0.469965699958385 no 1785 0.468004756539744 2571 17156417
SGTC_335 4077-0256 27.6 µM -0.0808360898604013 0.469769568374084 no 1786 0.467786153207637 2655 3121989
SGTC_1328 1441-0025 69.2 µM -0.0813871682891918 0.469572966044121 no 1787 0.467567026739314 2545 4562601
SGTC_1603 st002045 67.8 µM -0.081702172210223 0.469460588808728 no 1788 0.467441775481477 2560 5887985
SGTC_1134 3477-0009 42.5 µM -0.0820786480904697 0.469326284724441 no 1789 0.467292086090046 2675 3973534
SGTC_3314 9135860 59.4275 µM -0.0822623971725448 0.469260735304907 no 1790 0.467219027873476 2563 25252478
SGTC_3169 9102970 49.47 µM -0.0825291835098529 0.469165565213355 no 1791 0.467112956199632 2541 17027839
SGTC_1258 0671-0043 57.1 µM -0.0828166584665965 0.469063016889128 no 1792 0.46699866154462 2608 4298767
SGTC_1238 0333-0287 48.8 µM -0.0832679462698173 0.468902037241881 no 1793 0.466819243464254 2564 7226
SGTC_969 1313-0238 134 µM -0.0846056101016816 0.4684249068485 no 1794 0.466287469423452 2575 5212874
SGTC_3251 9135047 49.47 µM -0.0848747373579983 0.468328917490186 no 1795 0.466180487984164 2666 17682963
SGTC_1815 st051655 58.2 µM -0.0850027215451698 0.468283270139544 no 1796 0.466129613531217 2550 5984156
SGTC_1572 epiandrosterone 68.9 µM -0.0850911650204026 0.468251725780537 no 1797 0.466094457062778 2580 441302 A steroid.
SGTC_2533 agelasine 13.65 µM -0.0860982837461973 0.467892539679609 no 1798 0.465694143966075 2610 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1003 4049-0218 100 µM -0.0872038130387061 0.467498285827769 no 1799 0.465254754269347 2648 295161
SGTC_1681 tripelennamine 100 µM -0.0905423854117771 0.466307879244394 no 1800 0.463928106780923 2551 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_767 0929-0023 86 µM -0.0909065473099193 0.4661780511459 no 1801 0.463783423867949 2574 1204563
SGTC_1401 3807-4679 7.6 µM -0.0913718286677936 0.466012177982018 no 1802 0.463598572779184 2567 3291456
SGTC_118 0083-0097 135.343 µM -0.0929974901946088 0.465432674928515 no 1803 0.462952777558782 2595 5207356
SGTC_1188 1403-0014 4.57 µM -0.095090211848124 0.464686786030287 no 1804 0.462121586329934 2590 9614867
SGTC_113 0099-0221 2.5 µM -0.0980501300981899 0.463632022944387 no 1805 0.460946243522649 2570 89219
SGTC_2893 9048488 25.97 µM -0.0981854799796802 0.46358379724162 no 1806 0.460892506024107 2613 6467338
SGTC_1723 st034307 2.5525 µM -0.0987052257680714 0.463398614722576 no 1807 0.460686159783923 2648 867466
SGTC_929 2805-0021 398 µM -0.0998274260536257 0.462998808133497 no 1808 0.460240666981373 2675 3098024
SGTC_3335 9143315 29.6265 µM -0.10021359224321 0.462861237226855 no 1809 0.460087377644027 2638 4899691
SGTC_2749 bexarotene 57.39 µM -0.100410445856518 0.46279111024235 no 1810 0.4600092385428 2643 82146 An retinoic acid receptor inhibitor.
SGTC_1377 2944-0135 198 µM -0.101103247368615 0.46254431635908 no 1811 0.45973425011508 2654 1894137
SGTC_1777 st045864 34.765 µM -0.101429428991214 0.462428126983941 no 1812 0.459604787988755 2597 4691462
SGTC_1108 betulinic acid 729.144 nM -0.102552477656159 0.462028109645442 no 1813 0.459159080614086 2594 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_166 k072-0058 166.424 µM -0.103073102257466 0.461842682006034 no 1814 0.458952476293793 2576 5846229
SGTC_1113 artemisinin 1.17947 µM -0.105200918453181 0.461084917536234 no 1815 0.458108190973856 2587 2240 An anti-malaria and mitochondrial poison.
SGTC_3030 9087619 49.47 µM -0.105724164855652 0.460898598948448 no 1816 0.457900603509128 2617 25236973
SGTC_1873 rapamycin 2 nM -0.105910152286228 0.460832374251178 no 1817 0.457826819507815 2612 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1961 st076550 68.7 µM -0.106027165553903 0.460790709797366 no 1818 0.457780399335395 2699 1579337
SGTC_3109 9122853 49.47 µM -0.106203169570877 0.460728041550324 no 1819 0.457710578108791 2659 1234709
SGTC_1678 st019265 80.2 µM -0.107198976235063 0.460373491592547 no 1820 0.457315563798453 2628 5367020
SGTC_3067 9117431 49.47 µM -0.107335661658063 0.460324828161727 no 1821 0.457261347019775 2641 17150885
SGTC_2278 7948257 134.34 µM -0.107699318513236 0.460195360117293 no 1822 0.457117105058882 2592 1247028
SGTC_1278 0874-0585 172 µM -0.108958139764612 0.459747230949747 no 1823 0.456617846112358 2647 766306
SGTC_1009 4106-0057 9.87 µM -0.109765377463513 0.459459888381857 no 1824 0.456297724931564 2586 2928005
SGTC_1228 0124-0032 52.5 µM -0.110238648472678 0.459291433704466 no 1825 0.456110055998029 2668 X1228
SGTC_3040 9091894 49.47 µM -0.110470977726059 0.459208741792718 no 1826 0.456017932694694 2633 25236966
SGTC_2507 purpurin 79.67 µM -0.110520788422606 0.459191013123968 no 1827 0.455998182041821 2583 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3178 9107506 49.47 µM -0.111109576738807 0.458981457206075 no 1828 0.455764727313809 2705 8897194
SGTC_1671 st016596 74.5 µM -0.113805480533632 0.458022103304129 no 1829 0.45469599699289 2649 2829167
SGTC_1461 k072-0203 53.8 µM -0.114078714828988 0.457924884756977 no 1830 0.454587697581957 2574 5418714
SGTC_2568 diosmetin 100 µM -0.1143119003924 0.457841917800879 no 1831 0.454495274594795 2599 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1983 st071813 46.9 µM -0.114820193942914 0.457661074345536 no 1832 0.45429382123237 2671 11838595
SGTC_1964 st076914 61 µM -0.115463542885337 0.457432192718459 no 1833 0.454038857864196 2585 24208661
SGTC_516 3992-2719 87.3 µM -0.116620914257411 0.457020475023858 no 1834 0.453580231816787 2580 5350887 YDR037W KRS1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.117072516656151 0.45685983665748 no 1835 0.453401294237695 2578 6708784 An antioxidant flavonoid
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.117199145473656 0.456814795099948 no 1836 0.453351122033357 2609 97141
SGTC_1730 st033808 45.1 µM -0.1172051085684 0.456812674055554 no 1837 0.453348759385659 2619 1045166
SGTC_464 bw-b 70c 158 µM -0.117736299573317 0.456623736889092 no 1838 0.453138301947944 2749 5353454
SGTC_2083 5306046 65.942 µM -0.118808523446575 0.456242391860719 no 1839 0.4527135278919 2651 539837
SGTC_1698 5-fluorocytosine 1.055 µM -0.11888119973498 0.456216545409793 no 1840 0.452684738280965 2623 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_110 0850-0284 111.64 µM -0.118962443743445 0.456187652171231 no 1841 0.452652554991949 2593 3906265
SGTC_1209 2323-2347 50.3 µM -0.122015874838789 0.455101913553307 no 1842 0.451443222953506 2606 5412760
SGTC_346 4513-0042 7.16 µM -0.122929631723123 0.454777064818284 no 1843 0.45108141042882 2637 2827372
SGTC_446 go6976 132 µM -0.12355284003484 0.454555526029333 no 1844 0.450834667238271 2690 3501 A protein kinase C inhibitor.
SGTC_3228 9131799 49.47 µM -0.124241705753898 0.454310663722013 no 1845 0.450561950807638 2670 17015818
SGTC_132 0417-1715 25.805 µM -0.124350716967078 0.454271916485877 no 1846 0.450518796275577 2656 6769098
SGTC_1117 retinoic acid 1.10837 µM -0.124373052411941 0.454263977569533 no 1847 0.450509954361304 2699 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2645 abamectin 100 µM -0.124823262857698 0.45410395855164 no 1848 0.450331735163909 2646 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3259 9138485 49.47 µM -0.12514982505832 0.453987892687046 no 1849 0.450202469320923 2761 17646153
SGTC_1631 benzylvanillin 81.9 µM -0.12596023769406 0.453699874989848 no 1850 0.44988169977119 2751 75506
SGTC_2981 9013952 38.96 µM -0.126885655079312 0.453371014809605 no 1851 0.449515450227646 2693 2996344
SGTC_538 2922-0838 53.3 µM -0.127248296682352 0.45324215368489 no 1852 0.449371940405435 2622 777039
SGTC_2838 9002687 71.43 µM -0.127583765108064 0.453122952664774 no 1853 0.449239189845171 2613 6457060
SGTC_3269 9137823 49.47 µM -0.128217902037976 0.45289763818063 no 1854 0.448988266612204 2626 17682936
SGTC_2601 securinine 100 µM -0.128455346394788 0.452813275989723 no 1855 0.448894316903168 2665 442872 A GABA receptor antagonist.
SGTC_594 1487-1584 10.8 µM -0.128486530078966 0.452802196819839 no 1856 0.448881978654432 2670 5013332
SGTC_102 gallobenzophenone 83.616 µM -0.128790287827198 0.452694277444582 no 1857 0.448761795358223 2754 70837
SGTC_1075 aripiprazole 15.2 µM -0.129572537060359 0.452416375212147 no 1858 0.448452316145653 2622 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1829 berberine 14.4 µM -0.129907070474543 0.452297535820983 no 1859 0.448319975132878 2804 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2851 9015922 71.43 µM -0.131787488837559 0.451629617282348 no 1860 0.447576191347702 2764 2996893
SGTC_37 0566-0070 1.56 µM -0.133238796144089 0.451114211111492 no 1861 0.447002264735956 2753 1626686
SGTC_1942 st076330 65.2 µM -0.134185551358311 0.450778032068956 no 1862 0.446627925463552 2796 24208414
SGTC_1170 0310-0127 64.8 µM -0.135522255005317 0.450303448165957 no 1863 0.446099484811759 2721 774975
SGTC_355 1311-2252 105 µM -0.135953403042311 0.450150388283025 no 1864 0.445929058914083 2681 5338538
SGTC_566 0958-0068 16.5 µM -0.136410178376107 0.44998823866049 no 1865 0.445748513855752 2770 6815365
SGTC_3283 9109332 35.8195 µM -0.136691523137514 0.449888368885584 no 1866 0.445637315096677 2618 17027281
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.138438644749285 0.449268259294693 no 1867 0.444946878473041 2655 16486 A toxic proline analog.
SGTC_953 1188-0045 9.7 µM -0.138687537395861 0.449179929344531 no 1868 0.444848533319651 2766 6144426
SGTC_1588 farnesol 29.9 µM -0.13908341178105 0.449039441976336 no 1869 0.444692118148652 2659 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1105 epirubicin 18.1 µM -0.139640782239873 0.448841653933057 no 1870 0.44447190836093 2652 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_869 0564-0080 44.1 µM -0.141728630474142 0.448100875148616 no 1871 0.443647179682937 2707 6843321
SGTC_1135 dihydrocapsaicin 536.708 nM -0.143009400595984 0.447646541013753 no 1872 0.443141378453344 2633 107982 A Capsaicinoid.
SGTC_1506 4226-2149 212 µM -0.143977252951608 0.44730325532578 no 1873 0.442759215991258 2756 991114
SGTC_2050 5263056 171 µM -0.144598668114941 0.447082867570589 no 1874 0.442513874436237 2747 763468 YGL055W OLE1
SGTC_1089 terbinafine 2.25 µM -0.144605359486229 0.447080494533684 no 1875 0.442511232728906 2776 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1556 plumbagin 1.48 µM -0.144770324457557 0.447021991733898 no 1876 0.442446106502187 2654 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1039 k821-0043 94 µM -0.147613331951762 0.446013936264862 no 1877 0.441323966497606 2735 15992768
SGTC_770 0389-1121 67.2 µM -0.147654457613733 0.445999356733874 no 1878 0.441307737560518 2850 6753108
SGTC_320 4092-0846 5.34 µM -0.148608084652292 0.445661305245861 no 1879 0.44093144661212 2768 1359356
SGTC_581 0958-0271 211 µM -0.150024322429401 0.445159335725551 no 1880 0.440372712951585 2655 4591145
SGTC_274 sirtinol 40.1 µM -0.150050339227769 0.44515011518448 no 1881 0.440362449919849 2712 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.150591455064801 0.444958346561485 no 1882 0.440149001194559 2671 688803
SGTC_1094 duloxetine 25.4 µM -0.150831058182843 0.444873436581292 no 1883 0.440054492824493 2655 60834 A selective serotonin reuptake inhibitor.
SGTC_2341 7987486 176.74 µM -0.150987987355884 0.444817825766656 no 1884 0.439992595980043 2767 1258686
SGTC_2995 9067767 71.4286 µM -0.15139390250874 0.44467398711079 no 1885 0.439832499559228 2759 11673567
SGTC_2294 7971431 200 µM -0.152296065478987 0.444354325952387 no 1886 0.439476714008278 2787 5741572
SGTC_548 1436-0017 110 µM -0.152389654522916 0.44432116684801 no 1887 0.439439808138257 2763 9677137
SGTC_13 0199-0087 65 µM -0.152431889333564 0.444306202953802 no 1888 0.439423153450515 2665 4589825
SGTC_347 4534-1311 26.2 µM -0.152727411622921 0.444201500923725 no 1889 0.439306621504321 2656 2862016
SGTC_745 0469-0705 296 µM -0.153161161980381 0.444047832452781 no 1890 0.439135592247039 2803 3486736
SGTC_41 0478-0632 82.643 µM -0.153269599833272 0.444009416555094 no 1891 0.439092836602858 2679 3750424
SGTC_2927 9011802 47.9 µM -0.153301306645195 0.443998183993463 no 1892 0.43908033515087 2780 43912568
SGTC_2519 cryptotanshinone 88.04 µM -0.154609985305987 0.443534606449129 no 1893 0.43856439876332 2757 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2337 9009472 200 µM -0.155008139426756 0.443393582306347 no 1894 0.438407450266486 2785 5742383
SGTC_2675 theaflavin digallate 100 µM -0.155176513894737 0.443333947091295 no 1895 0.438341081595293 2712 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_529 4076-0302 30.3 µM -0.156414363502089 0.442895562462351 no 1896 0.437853208041755 2702 5816522
SGTC_917 harmaline 728.087 nM -0.156614388650012 0.442824730071526 no 1897 0.437774380993615 2775 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_952 1185-0122 232 µM -0.157983453988872 0.442339969349175 no 1898 0.437234918389276 2650 678600
SGTC_1462 k081-0014 26.5 µM -0.159998015735674 0.441626807454448 no 1899 0.43644131864763 2713 3270634
SGTC_719 2810-4230 27.3 µM -0.160058036598963 0.441605562750173 no 1900 0.436417678434567 2675 721079
SGTC_974 1326-0144 138 µM -0.160949638474388 0.441289995333011 no 1901 0.436066533029006 2710 5411856
SGTC_162 k030-0015 37.8 µM -0.161202582979695 0.441200476677317 no 1902 0.435966923401111 2789 1809920 YMR134W ERG29
SGTC_924 2046-0044 21.3 µM -0.162128739516358 0.44087272970828 no 1903 0.435602237366085 2677 3623589
SGTC_224 benfluorex 43.875 µM -0.162536637449159 0.440728396194645 no 1904 0.435441639664887 2714 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_272 doxorubicin 8.13 µM -0.164371128185035 0.44007936451584 no 1905 0.434719495395337 2660 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1907 st060210 83.7 µM -0.164600932267998 0.439998072537551 no 1906 0.434629048691414 2854 688793
SGTC_3136 9095672 49.47 µM -0.165579605796946 0.4396519003206 no 1907 0.434243898971179 2632 17217380
SGTC_3115 9123671 49.47 µM -0.169160702078159 0.438385605496031 no 1908 0.432835119733436 2674 3286988
SGTC_1371 2421-0008 32.7 µM -0.169813943476071 0.438154683458764 no 1909 0.432578230444583 2753 2827552
SGTC_1294 1000-1494 117 µM -0.169853162664661 0.438140820072643 no 1910 0.432562808277727 2729 712797 YDL207W GLE1
SGTC_537 1334-0398 209 µM -0.171199865370957 0.437664827339423 no 1911 0.432033306675233 2749 5846986
SGTC_1925 st057770 10.1 µM -0.171743750887775 0.437472616265515 no 1912 0.431819494286568 2707 5989122
SGTC_773 4358-1457 44.6 µM -0.171959859741682 0.437396246722474 no 1913 0.431734543069285 2690 1186886
SGTC_2221 6807166 181.081 µM -0.1725843818113 0.437175563353464 no 1914 0.43148906459118 2724 674925
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.173363005505671 0.436900453461606 no 1915 0.431183051048017 2813 5379071
SGTC_478 N-arachidonylglycine 10 µM -0.173444236741097 0.43687175391168 no 1916 0.431151128043183 2699 5283389
SGTC_3345 9148410 3.559 µM -0.173521948991778 0.436844297954048 no 1917 0.431120588382592 2810 4903596
SGTC_51 1013-0126 23.419 µM -0.17409512553735 0.436641802466719 no 1918 0.430895351980539 2854 1627850
SGTC_795 0685-0265 78 µM -0.174967296206795 0.43633370828422 no 1919 0.430552665495675 2713 302754
SGTC_3 0833-0587 95.581 µM -0.175741061911088 0.436060407969338 no 1920 0.430248687286439 2742 5382644
SGTC_712 r015-0009 80.6 µM -0.17610753632824 0.435930976881588 no 1921 0.430104730163536 2833 6813872 YLR060W FRS1
SGTC_2490 carminic acid 95.39 µM -0.176410503466192 0.43582398041486 no 1922 0.429985726749025 2668 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1180 1193-0155 285 µM -0.176973409538184 0.435625195882708 no 1923 0.429764637997912 2851 2921347
SGTC_2398 5228213 48.84 µM -0.177147369253666 0.435563767072731 no 1924 0.429696317487044 2835 80771 YMR134W ERG29
SGTC_1157 4092-0394 27.6 µM -0.177435381061141 0.435462067504834 no 1925 0.429583209067347 2901 3659885
SGTC_157 1348-1695 65.819 µM -0.178161066728329 0.435205840288987 no 1926 0.429298242377104 2722 5380510
SGTC_1240 0356-0016 42.1 µM -0.179915862974176 0.434586364332932 no 1927 0.428609310780681 2799 4305613
SGTC_426 0988-0037 14.6 µM -0.180434680490661 0.434403242713656 no 1928 0.428405665001708 2708 5383008
SGTC_2311 7694451 200 µM -0.18121043370578 0.434129459440625 no 1929 0.428101202634163 2806 2163142
SGTC_1740 st038286 13.222 µM -0.181392160711485 0.434065327866352 no 1930 0.428029885830324 2928 716786
SGTC_2249 haloperidol 116.36 µM -0.181569098165688 0.434002888195205 no 1931 0.427960450893024 2708 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1169 aniline yellow 25.8 µM -0.182484169842776 0.433679993763414 no 1932 0.427601388208071 2773 6051 A DNA damaging agent.
SGTC_2197 6588183 93.1375 µM -0.183621854538075 0.433278609294125 no 1933 0.427155058596183 2742 884136
SGTC_1546 5-methoxyflavanone 78.7 µM -0.183751571020794 0.433232848620205 no 1934 0.427104174916941 2811 147795
SGTC_511 blebbistatin 171 µM -0.184479318244952 0.432976134536099 no 1935 0.426818725178719 2869 3476986 A myosin inhibitor.
SGTC_1043 0916-0009 19.3 µM -0.186084418285257 0.432410032867019 no 1936 0.426189280453742 2849 3101130
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.1867591392961 0.432172107306987 no 1937 0.425924742641942 2764 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1378 2093-0007 380 nM -0.187093358181724 0.4320542614544 no 1938 0.425793717808227 2844 3618014
SGTC_94 0334-0113 514.748 µM -0.188605573456788 0.431521128819744 no 1939 0.425200982115073 2752 6795178
SGTC_693 4161-2696 114 µM -0.190437959689208 0.430875286879899 no 1940 0.424482977188543 2853 805759
SGTC_2623 humulene 100 µM -0.190451452126321 0.430870532025556 no 1941 0.424477691218291 2812 6187145 An anti-inflammatory.
SGTC_3195 9113082 49.47 µM -0.190702698555708 0.430781992389877 no 1942 0.424379262176437 2749 17018038
SGTC_3272 9137413 49.47 µM -0.192253552522096 0.430235546202054 no 1943 0.423771799680497 2735 17614870
SGTC_1824 st053723 68.6 µM -0.192257049884141 0.430234314050815 no 1944 0.4237704299837 2775 675225
SGTC_57 miconazole 162.5 nM -0.192806884599235 0.430040610927772 no 1945 0.423555105764071 2700 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1500 4488-1866 171 µM -0.193060700220536 0.429951199045142 no 1946 0.423455715134122 2900 2900003
SGTC_2373 9071805 200 µM -0.19377332632012 0.429700180752823 no 1947 0.423176686821872 2796 10149009
SGTC_670 4204-0025 119 µM -0.194007812652924 0.429617590549666 no 1948 0.423084882259813 2865 719039
SGTC_2742 clothiapine 36.27 µM -0.194921816517439 0.429295691777896 no 1949 0.422727077329383 2780 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_645 0845-0943 5.41 µM -0.195550660038125 0.42907424958696 no 1950 0.42248094106383 2796 1885106
SGTC_1973 st070275 50.2 µM -0.196846930315445 0.428617848932196 no 1951 0.421973662231103 2711 17118334
SGTC_1342 1486-1464 234 µM -0.197366905183311 0.428434799030715 no 1952 0.421770213026105 2764 3253938
SGTC_797 k781-0471 270 µM -0.197480377638181 0.428394854680415 no 1953 0.421725817729199 2773 23738129
SGTC_1519 esterone 74 µM -0.197609068281643 0.428349554141089 no 1954 0.42167546962737 2743 698 A steroid.
SGTC_2580 diallyl disulphide 81.36 µM -0.198739252663563 0.42795175727497 no 1955 0.42123335862596 2781 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_135 0933-0004 26.348 µM -0.199998100537336 0.427508760258703 no 1956 0.420741033332035 2866 21230617 YGL099W LSG1
SGTC_3174 9107204 49.47 µM -0.200310134706092 0.427398967451293 no 1957 0.420619018412985 2886 3938802
SGTC_2140 5586273 200 µM -0.202405591808769 0.426661802866514 no 1958 0.41979982862145 2738 854421
SGTC_1379 2144-0755 36.5 µM -0.20246678009206 0.426640281167203 no 1959 0.419775913116682 2882 5392327
SGTC_931 2812-0076 566 µM -0.203433669812176 0.426300226959802 no 1960 0.419398042641679 2736 3450959
SGTC_1943 st076331 65.2 µM -0.205029100916091 0.4257392352358 no 1961 0.418774694361953 2854 24208415
SGTC_92 0063-0024 660.874 µM -0.205791508523784 0.425471207486526 no 1962 0.418476887227293 2703 3594437
SGTC_1774 st048371 48.465 µM -0.207353727273647 0.424922110319079 no 1963 0.417866808743081 2779 4242727
SGTC_2359 9039622 200 µM -0.207556662302927 0.424850792273342 no 1964 0.417787572919758 2765 6463596
SGTC_2696 st077691 74.316 µM -0.207599667852521 0.424835679024136 no 1965 0.417770781865044 2912 757133
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.207740832877964 0.424786070803149 no 1966 0.417715666551584 2764 15053
SGTC_2204 7233102 200 µM -0.208364695396161 0.424566847278034 no 1967 0.417472110161872 2789 2172480
SGTC_2859 9028643 45.46 µM -0.208692538426267 0.42445165351187 no 1968 0.417344132683584 2870 17151580
SGTC_897 1000-0139 31.4 µM -0.208738778192232 0.424435406826279 no 1969 0.417326083137861 2933 6151020
SGTC_557 1315-0110 16.2 µM -0.210238651639172 0.423908484916417 no 1970 0.416740706988385 2780 6833801
SGTC_444 curcumin 90.4 µM -0.210891477975904 0.423679182327098 no 1971 0.41648597708697 2909 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1076 itraconazole 331 nM -0.211002422050298 0.423640216240129 no 1972 0.416442690691273 2763 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2125 5246583 200 µM -0.21186553346141 0.423337097374643 no 1973 0.41610597024363 2854 835267
SGTC_173 1273-0061 2.693 µM -0.214415984175649 0.422441662169053 no 1974 0.415111338969458 2882 2847414 YPL266W DIM1
SGTC_2467 5474540 200 µM -0.21595884980584 0.421900173211291 no 1975 0.414509911873056 2777 5413519
SGTC_1348 1493-0373 93.8 µM -0.217175990800551 0.42147310570018 no 1976 0.41403559736309 2867 3010129
SGTC_1810 st050138 53 µM -0.217647060365444 0.421307842703778 no 1977 0.413852057230181 2839 3444541
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.218329272126533 0.421068530321212 no 1978 0.413586284342654 2883 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2748 diazoxide 86.69 µM -0.218485383467533 0.421013772276441 no 1979 0.413525472772927 2873 3019 A potassium channel activatior.
SGTC_1881 5652484 16 µM -0.219712397825666 0.420583434617232 no 1980 0.4130475742611 2920 2255129
SGTC_2900 5328528 85.29 µM -0.219754030181624 0.420568835006699 no 1981 0.413031361514233 2801 795359
SGTC_1752 st044819 83.042 µM -0.219775200952836 0.42056141089479 no 1982 0.413023117109652 2829 441209 YML126C ERG13
SGTC_1174 0739-0097 51.1 µM -0.220011516366244 0.420478542328613 no 1983 0.412931092841163 2854 728447
SGTC_743 1275-0778 158 µM -0.221322105060275 0.42001902314832 no 1984 0.412420819687352 2914 2849257 YMR203W TOM40
SGTC_1097 itavastatin 7.23 µM -0.222289735187638 0.419679822168465 no 1985 0.412044171180106 2829 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2558 carylophyllene oxide 100 µM -0.223472740448302 0.419265202917907 no 1986 0.411583798332638 2786 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2874 9043904 71.43 µM -0.223484468294999 0.419261092994441 no 1987 0.411579234986316 2864 4463428
SGTC_1991 st073000 8.92 µM -0.225632842062997 0.418508362862126 no 1988 0.410743497596008 3002 4301969 YIL048W NEO1
SGTC_2153 5569715 200 µM -0.226073009068462 0.418354177374755 no 1989 0.410572318406464 2810 2054701
SGTC_2281 7943571 200 µM -0.227243718138902 0.417944152439029 no 1990 0.410117117309318 2976 1244024
SGTC_2641 levomentholum 100 µM -0.227489844498334 0.417857961357709 no 1991 0.410021432581857 2829 16666
SGTC_2298 7976326 193.81 µM -0.230971569899097 0.416639119198822 no 1992 0.408668444412141 2823 2235818
SGTC_1473 k844-0725 134 µM -0.231843780917723 0.416333910654916 no 1993 0.408329675544274 2843 54682906
SGTC_1321 1326-2144 215 µM -0.232578818333884 0.416076741756659 no 1994 0.408044238411068 2940 3513030
SGTC_1958 st076513 41.9 µM -0.232588100609568 0.416073494379219 no 1995 0.408040634135944 2799 732122 YGL099W LSG1
SGTC_1898 st060199 18.6 µM -0.232809703987666 0.415995968776765 no 1996 0.407954588631808 2814 688866
SGTC_2108 5365811 200 µM -0.234031220150036 0.415568692988035 no 1997 0.407480370706467 2939 780283
SGTC_2120 5538279 151.968 µM -0.234645707926468 0.41535378818013 no 1998 0.407241865001324 2853 2058197
SGTC_1164 k060-0068 93.7 µM -0.234950778385605 0.415247105290993 no 1999 0.407123468506306 2819 5963676
SGTC_1019 4262-0212 3.4 µM -0.236044184124127 0.414864793584615 no 2000 0.406699192363824 2909 4677213
SGTC_1986 st071812 45 µM -0.236981469719728 0.414537133784619 no 2001 0.406335582930118 2843 11838594
SGTC_2189 6047310 154.431 µM -0.237530895154044 0.414345091216659 no 2002 0.406122477019692 2794 711535
SGTC_2944 9067346 25.62 µM -0.238003167855502 0.414180032472165 no 2003 0.405939318601148 2992 6473075
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.238236269474695 0.414098569319878 no 2004 0.405848923917468 2943 16725076
SGTC_492 tmb-8 126 µM -0.238779042477261 0.413908898136421 no 2005 0.405638460953686 2902 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2890 9046729 58.44 µM -0.239235066568483 0.413749556746783 no 2006 0.405461656398886 2856 903329
SGTC_2795 7780010 54.55 µM -0.24011004394097 0.413443866826412 no 2007 0.40512247400564 2967 953673
SGTC_2175 5807670 165.306 µM -0.240805438829987 0.413200954851974 no 2008 0.404852957036144 2957 241186
SGTC_2121 5257820 149.641 µM -0.24159074295155 0.412926676169373 no 2009 0.404548647850732 2979 791256
SGTC_1193 1488-0126 41.5 µM -0.242392274095677 0.412646773794392 no 2010 0.404238110146378 2857 1384710
SGTC_3110 9122132 49.47 µM -0.243066400285426 0.412411396831605 no 2011 0.403976979719605 2988 918317
SGTC_1015 4130-4525 82 µM -0.245321316938273 0.411624302617641 no 2012 0.40310382371659 2858 1363237
SGTC_454 lyso-paf C-16 6.67 µM -0.246143004292133 0.41133757518425 no 2013 0.402785767144191 2914 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2671 danthron 100 µM -0.248144622119034 0.410639309995674 no 2014 0.402011255786844 2902 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1432 4049-0298 68.4 µM -0.24814666771336 0.410638596533715 no 2015 0.402010464455331 2952 741646
SGTC_2166 5933061 31.504 µM -0.248569802486199 0.410491022036364 no 2016 0.401846784784109 3344 2877375
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.249820465676978 0.410054908945901 no 2017 0.401363096073225 2869 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1415 3966-0071 78.1 µM -0.251344226196982 0.409523715683534 no 2018 0.4007739923876 2867 2893185
SGTC_901 1112-0062 60.1 µM -0.251736544363558 0.409386977748413 no 2019 0.400622354048438 2860 1908457
SGTC_630 4356-0227 183 µM -0.253333567870412 0.408830467710807 no 2020 0.400005229257687 2869 779312
SGTC_1427 4048-4900 550 nM -0.254994417054721 0.408251911448076 no 2021 0.399363705640391 2973 24132586
SGTC_1840 st055363 71 µM -0.256273099448323 0.407806619017748 no 2022 0.398869983672515 2877 676033
SGTC_1746 st038117 42 µM -0.260725337022921 0.406257090225846 no 2023 0.397152162773042 2971 2898218
SGTC_3239 9133757 49.47 µM -0.260928884543318 0.406186283711743 no 2024 0.397073674787127 2843 17036923
SGTC_624 k048-0052 28 µM -0.26160633288169 0.405950647067119 no 2025 0.396812480542236 2915 6835531
SGTC_1685 st024049 53.0905 µM -0.263445761160833 0.405311011369225 no 2026 0.396103511786623 2963 1941139
SGTC_1101 ebselen 5.29 µM -0.265081799725169 0.404742313994571 no 2027 0.395473223835998 3035 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2124 5246320 200 µM -0.265094639540505 0.404737851587355 no 2028 0.395468278343769 2965 579342
SGTC_412 gemfibrozil 100 µM -0.265174883806396 0.404709963414679 no 2029 0.39543737116276 2917 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1053 3366-3204 134 µM -0.265686683610074 0.404532103392029 no 2030 0.395240259921402 2932 3632071 YPR165W RHO1
SGTC_2569 tetrandrine 100 µM -0.266004349426957 0.404421718486913 no 2031 0.395117929655651 2933 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2648 atorvastatin 78.68 µM -0.266378461070407 0.40429172911805 no 2032 0.394973875862405 2976 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_906 1165-0455 526 µM -0.267122574349889 0.404033209869471 no 2033 0.394687393547368 2872 3252859
SGTC_1680 diphenhydramine 100 µM -0.267244869540621 0.403990726177561 no 2034 0.394640315556155 2927 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1733 st037357 54.9 µM -0.267551188772117 0.403884319999376 no 2035 0.394522403576793 2831 1272339 YGL099W LSG1
SGTC_2008 4012253 172 µM -0.26787726378691 0.403771059065608 no 2036 0.394396897588762 2865 603940
SGTC_2899 9053889 58.44 µM -0.270719387192941 0.402784200789071 no 2037 0.393303432306371 2970 6470052
SGTC_2717 st081029 62.2815 µM -0.271413573992585 0.402543255120854 no 2038 0.393036481600865 3000 5292846
SGTC_3098 9119039 49.47 µM -0.272115073787454 0.402299808783366 no 2039 0.392766769760528 2865 17161528
SGTC_1731 st035964 63 µM -0.273802147337124 0.401714487259081 no 2040 0.392118336662014 2926 6739575
SGTC_833 3852-0053 558 µM -0.276207325286917 0.400880404489504 no 2041 0.391194415622526 3060 3123681
SGTC_1856 st057054 55.7 µM -0.276834362648778 0.400663030587206 no 2042 0.390953647170843 3135 1266018
SGTC_499 genistein 192 µM -0.278062726543306 0.400237285115394 no 2043 0.390482103859174 2951 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2964 9083345 53.42 µM -0.27854537964316 0.400070032101663 no 2044 0.390296867419621 2957 17741579
SGTC_1260 0700-1617 7.75 µM -0.280664465867904 0.399335925785687 no 2045 0.389483882885142 3018 2853078
SGTC_1531 st059297 52.4 µM -0.283839599435252 0.398236644015721 no 2046 0.388266653019427 3019 7566702
SGTC_2669 eugenol 100 µM -0.283896687351476 0.398216886631554 no 2047 0.388244777605056 2980 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1649 st011737 51.3 µM -0.284178413742878 0.398119388619669 no 2048 0.388136828576772 2956 1761035
SGTC_2934 9036370 36.88 µM -0.287321735572479 0.397032001268843 no 2049 0.386932990699505 3009 6462800
SGTC_3211 9128781 49.47 µM -0.288247549411151 0.396711881311346 no 2050 0.386578626707775 3024 17194361
SGTC_3262 9137218 49.47 µM -0.289639587805627 0.396230685290561 no 2051 0.386045988918865 2831 17650664
SGTC_424 splitomicin 100 mM -0.290005755883482 0.396104135537122 no 2052 0.385905917093661 3004 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_433 pimozide 108 µM -0.290202812409519 0.396036036220447 no 2053 0.385830542381276 2867 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1776 st049249 45.9 µM -0.290311474453404 0.395998485860233 no 2054 0.385788980667044 2966 1822314
SGTC_803 4488-1585 147 µM -0.290608864081262 0.395895721813863 no 2055 0.385675239993254 3044 747204
SGTC_2429 5902844 64.44 µM -0.290680430915585 0.395870992718893 no 2056 0.385647869759326 3078 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1390 3413-2614 145 µM -0.29140182328431 0.395621747318288 no 2057 0.385372010124162 2981 3421432
SGTC_2743 auranofin 4.32 µM -0.29160180125246 0.395552661279539 no 2058 0.385295549031926 2949 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_329 k048-0121 21.3 µM -0.292770704617005 0.395148908002556 no 2059 0.384848710946267 2992 6832902
SGTC_2458 5808907 16.39 µM -0.292875172503052 0.395112829011042 no 2060 0.38480878331715 3084 2731747
SGTC_972 1319-0219 195 µM -0.293512183523619 0.394892850583889 no 2061 0.384565344136204 3014 23903702
SGTC_1716 st033144 30.6155 µM -0.293627138115221 0.394853156987326 no 2062 0.384521418105971 3088 674617
SGTC_225 nsc-122657 1.016 µM -0.294352283901903 0.394602790731989 no 2063 0.384244362233531 3040 275685
SGTC_1139 k015-0024 46.9 µM -0.294359550828005 0.394600281948939 no 2064 0.384241586063902 3053 2766652
SGTC_2306 7482397 179.52 µM -0.29559935012407 0.394172326332318 no 2065 0.383768034996502 3090 891448
SGTC_725 1497-0963 19 µM -0.297708759938087 0.393444491165973 no 2066 0.382962728487177 3050 3549977
SGTC_2316 5844804 197.44 µM -0.298965175133768 0.3930111517406 no 2067 0.382483308604135 3057 776813
SGTC_834 0312-0008 75.7 µM -0.299331801528376 0.392884726723162 no 2068 0.382343446092005 2929 6385573 YIL048W NEO1
SGTC_1948 st076329 66.6 µM -0.299727723000438 0.392748212474463 no 2069 0.382192425181057 2866 24208413
SGTC_1975 st070967 30.8 µM -0.300837407509626 0.39236566213905 no 2070 0.381769240941569 3099 261391
SGTC_174 3553-0389 74.3 µM -0.302118949099631 0.391923995559708 no 2071 0.381280693854475 3075 738071
SGTC_328 k915-0120 63.5 µM -0.302199846722834 0.391896119916006 no 2072 0.381249860539518 3051 6624543
SGTC_1679 SEC14.276 6.7 µM -0.303274102945178 0.391526006158244 no 2073 0.380840490127084 3067 1005053 YMR079W SEC14
SGTC_2988 9073640 71.4286 µM -0.303532732106691 0.391436915240781 no 2074 0.380741953347602 3152 9102229
SGTC_2955 9076254 12.21 µM -0.303589433278632 0.39141738394508 no 2075 0.380720351438808 3060 16459619
SGTC_76 0433-0009 400.328 µM -0.305079374986972 0.390904256611074 no 2076 0.380152849625646 3054 2841569
SGTC_904 1141-0088 396 µM -0.30657476312238 0.390389444473274 no 2077 0.379583532647289 2988 1378119
SGTC_2926 9010726 65.15 µM -0.306737417362396 0.390333459626124 no 2078 0.379521623421757 3066 2994293
SGTC_2025 5147754 141 µM -0.306775931616022 0.390320203528722 no 2079 0.379506964633526 3028 315777 YLR208W SEC13
SGTC_709 3807-1509 243 µM -0.306844921564726 0.390296458418392 no 2080 0.379480707020403 2958 1886677 YPL242C IQG1
SGTC_2713 st079149 53.4 µM -0.3086132576871 0.389687968564745 no 2081 0.37880786733515 3029 3103253
SGTC_2974 9094440 9.66 µM -0.311664787257321 0.388638564357403 no 2082 0.377647645791445 3132 25236134
SGTC_3111 9122088 49.47 µM -0.311748280952049 0.388609862716623 no 2083 0.377615916124735 2994 16876704
SGTC_1116 jasmonic acid 1.58368 µM -0.312600757853395 0.388316851632672 no 2084 0.377292001140255 3106 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1839 st053978 48 µM -0.313619259869742 0.387966858173153 no 2085 0.376905114897143 3047 3788398
SGTC_941 3237-0776 460 µM -0.313725869209956 0.387930228673653 no 2086 0.376864625612813 3143 760008
SGTC_2703 st077852 53.4 µM -0.314939851628779 0.387513191452867 no 2087 0.376403661438322 3090 6281836
SGTC_1144 3486-0183 12.5 µM -0.315470465426813 0.387330951362485 no 2088 0.376202236105459 2972 6744069
SGTC_1896 st058441 89 µM -0.315573174573763 0.387295678621382 no 2089 0.376163250767149 3005 688759
SGTC_1273 0849-0096 14.1 µM -0.316009769114303 0.387145752156368 no 2090 0.375997546566946 2995 5286025
SGTC_1507 4075-3230 155 µM -0.316253910441849 0.387061921417817 no 2091 0.375904895630191 2948 659771
SGTC_55 0767-0285 6.563 µM -0.316339422062959 0.387032560562096 no 2092 0.3758724459054 3063 3116166
SGTC_3060 1327-0027 12.5 µM -0.316667211058831 0.386920018510559 no 2093 0.37574806553369 3030 16000455 YPR107C YTH1
SGTC_1633 st005664 67.9 µM -0.318445776928874 0.386309537216769 no 2094 0.375073409546466 2930 2063822
SGTC_2239 6685329 187.64 µM -0.31925389968436 0.386032247141919 no 2095 0.374766993807251 3099 805680
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.31962226109836 0.385905871091204 no 2096 0.374627348501477 2971 279621
SGTC_1638 st008370 60.6 µM -0.319644797432601 0.38589813980317 no 2097 0.374618805541647 2952 24207134
SGTC_1879 gemcitabine 100 µM -0.321972841167061 0.385099728571871 no 2098 0.373736634722376 2987 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1796 st049173 110.4 µM -0.322153660515986 0.385037736238409 no 2099 0.373668144050608 3084 94134
SGTC_75 0159-0059 199.013 µM -0.322477920494016 0.384926573898933 no 2100 0.373545330995277 3266 5377270
SGTC_2198 6589944 200 µM -0.322943830894088 0.384766867724818 no 2101 0.373368890506551 3013 5290268
SGTC_2661 dactinomycin 12.96 µM -0.323050351753033 0.38473035692807 no 2102 0.373328554734044 3004 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_125 0133-0007 11.75 µM -0.324994781538313 0.384064069470321 no 2103 0.372592510617785 3116 26541
SGTC_812 4251-0442 148 µM -0.327729522356305 0.383127550300057 no 2104 0.371558089744145 3123 5723007
SGTC_2701 st077767 14.721 µM -0.328702751503775 0.382794429840804 no 2105 0.371190187200551 3013 5721188
SGTC_2211 7117706 200 µM -0.329126431309145 0.382649438222903 no 2106 0.371030063435171 3079 822771
SGTC_640 3381-0960 37.1 µM -0.330314713335882 0.382242872395106 no 2107 0.370581088324033 3050 1745025
SGTC_553 k007-0256 45.7 µM -0.331759167458996 0.381748833150208 no 2108 0.370035559621325 3048 6287000
SGTC_1414 3917-0015 5.4 µM -0.331881602945855 0.381706966008779 no 2109 0.369989331267194 3093 6618702
SGTC_2755 lomerizine 42.69 µM -0.33203649922478 0.381654000795657 no 2110 0.369930849280633 3024 3949 A calcium channel blocker.
SGTC_1136 pergolide 1.05886 µM -0.332201281713636 0.381597657525592 no 2111 0.369868638000123 2973 47811 A dopamine receptor agonist.
SGTC_1838 st055369 84.5 µM -0.334382183204009 0.380852189300703 no 2112 0.369045591089031 2978 676036
SGTC_3057 9095946 49.47 µM -0.334671138856331 0.38075345258295 no 2113 0.368936587517895 2954 24540043
SGTC_1353 1498-1206 8.11 µM -0.335090795089445 0.380610069048818 no 2114 0.368778298163859 3023 6756808
SGTC_2787 5284540 71.43 µM -0.335870395551169 0.380343747263579 no 2115 0.368484301214988 3044 736958
SGTC_362 0310-0100 9.03 µM -0.33769220959896 0.37972161289856 no 2116 0.367797573046731 3124 790235
SGTC_922 1866-0035 480 µM -0.338448140749527 0.379463559953389 no 2117 0.367512750590547 2979 3156169
SGTC_2516 gossypol 71.55 µM -0.339668631703949 0.379047033137541 no 2118 0.367053043468428 3146 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_687 k029-0044 34.9 µM -0.34096053178521 0.378606288919467 no 2119 0.366566647159097 3133 5829338
SGTC_3157 9099274 49.47 µM -0.341775940660476 0.378328185507147 no 2120 0.366259758508287 3143 17217662
SGTC_1636 st007707 68.9 µM -0.342436134947413 0.378103065751541 no 2121 0.366011349318311 3218 403051
SGTC_1319 1306-0155 43.7 µM -0.342652948393664 0.378029143522387 no 2122 0.365929781861189 3004 3122360
SGTC_184 1494-0393 24.714 µM -0.343274408255711 0.377817282438097 no 2123 0.365696015832734 2964 3090647
SGTC_2949 9072542 2.23 µM -0.344211452935877 0.377497905232057 no 2124 0.365343634895409 3101 16457352
SGTC_736 0958-0254 92.6 µM -0.345097866477088 0.377195861945435 no 2125 0.365010398673621 3116 6812352
SGTC_1787 fluconazole 80 µM -0.34810112383476 0.376173068592448 no 2126 0.363882120177163 3118 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3159 9100096 49.47 µM -0.348863814055558 0.375913463877193 no 2127 0.363595776322641 2929 25236875
SGTC_1261 0712-0010 12.7 µM -0.350112803383188 0.375488453847333 no 2128 0.363127021279406 3212 2840123
SGTC_197 4544-0043 41.561 µM -0.350335704166977 0.375412620336266 no 2129 0.363043386478879 3004 896523
SGTC_1843 st055809 45.5 µM -0.351059145361728 0.375166530174332 no 2130 0.362771988481174 3165 16413835
SGTC_2431 5490079 200 µM -0.351080154424151 0.375159384362351 no 2131 0.362764107988643 3070 5722345
SGTC_1966 st070145 16.1 µM -0.35455973630121 0.373976467168299 no 2132 0.361459722285367 2953 3748532
SGTC_165 k038-0023 64.381 µM -0.355456925107541 0.373671651090867 no 2133 0.36112365469337 3037 46368543
SGTC_2496 diffractaic acid 79.83 µM -0.355867139448098 0.373532308822881 no 2134 0.360970032926047 3267 94870 An apoptosis inducer which activates caspases.
SGTC_3035 9091303 49.47 µM -0.356371950828777 0.373360856372394 no 2135 0.360781016154738 3065 25237002
SGTC_337 1315-0038 354 µM -0.358782376532783 0.372542533606329 no 2136 0.359878948797037 3050 1626437
SGTC_121 0557-0495 61.343 µM -0.359172643659812 0.372410094622305 no 2137 0.359732970132072 3051 3104427
SGTC_1223 0764-0573 147 µM -0.362048274178628 0.371434701970799 no 2138 0.358657978178391 3044 1609797
SGTC_2563 tomatine 8.54 µM -0.362898396388277 0.371146504509139 no 2139 0.358340392353491 3259 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3093 9117344 49.47 µM -0.364679543200449 0.370542917521011 no 2140 0.357675315331055 3170 24824913
SGTC_3227 9130768 49.47 µM -0.36467974057266 0.37054285065403 no 2141 0.357675241656522 3056 17720899
SGTC_2676 harmalol 100 µM -0.365074552612001 0.370409101616821 no 2142 0.357527877968868 3142 5459187 A monoamine oxidase inhibitor
SGTC_1202 1988-0068 29.6 µM -0.365918040822223 0.370123408686184 no 2143 0.357213116977163 3048 2850480
SGTC_3051 9093778 49.47 µM -0.366226877072806 0.370018822486111 no 2144 0.35709789411973 3102 17217378
SGTC_158 k038-0087 26.446 µM -0.366653984219571 0.369874200143929 no 2145 0.356938567377445 2997 X158
SGTC_999 SEC7.066 22.7 µM -0.366675329836018 0.369866972807821 no 2146 0.356930605328425 3044 740511 YDR170C SEC7
SGTC_2093 5331342 194.4 µM -0.367547895606897 0.369571573246097 no 2147 0.356605186191155 3189 33839
SGTC_458 nppb 133 µM -0.367778417254378 0.369493544991119 no 2148 0.35651923168656 3239 4549 A chloride channel blocker.
SGTC_2846 9008642 19.48 µM -0.368056963983802 0.369399268109581 no 2149 0.356415379813597 3155 2992898
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.369058470588857 0.369060363257924 no 2150 0.356042071451763 3245 94937 An inhibitor of serotonin biosynthesis.
SGTC_2022 5136654 200 µM -0.370557014535963 0.368553453565346 no 2151 0.355483751763412 3186 1713771
SGTC_431 k089-0097 107 µM -0.371103741541944 0.368368570114367 no 2152 0.355280132178269 3146 5499420
SGTC_2680 butyl paraben 22.24 µM -0.372640071117216 0.367849201850968 no 2153 0.354708172507859 3120 7184 An antifungal and steroid mimetic.
SGTC_2406 ethylparaben 405.7 µM -0.372693532585663 0.367831133125353 no 2154 0.354688275241119 2951 8434 A possible steroid mimic.
SGTC_2640 pentamidine 10.38 µM -0.373478538221629 0.367565853282362 no 2155 0.354396157849632 3172 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3342 9147791 14.508 µM -0.373509813058152 0.367555285769641 no 2156 0.354384521586589 3052 1838168
SGTC_947 3447-0010 211 µM -0.374589875253142 0.367190403128165 no 2157 0.353982752027384 3115 748350
SGTC_3296 9122258 64.045 µM -0.375121233315337 0.367010935847986 no 2158 0.353785153126269 3156 4730474
SGTC_3164 9100705 49.47 µM -0.375730717221593 0.366805117185302 no 2159 0.353558549655366 3190 17174235
SGTC_1641 st009299 47.1 µM -0.37728925461932 0.366278983718436 no 2160 0.35297932836995 3149 4046054
SGTC_847 0342-0274 5.54 µM -0.378551864715758 0.365852934026837 no 2161 0.352510336329212 3178 18097
SGTC_32 0928-0142 34.1 µM -0.37919238579906 0.365636862560516 no 2162 0.352272502687172 3161 2244242
SGTC_2756 carbadox 75.1 µM -0.380365675069987 0.365241179260652 no 2163 0.351836995287324 3086 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2232 chlorophetanol 41.5365 µM -0.381156245113448 0.364974646089644 no 2164 0.351543657075636 3172 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2711 st079103 59.1 µM -0.382617163662095 0.364482283019443 no 2165 0.351001821102458 3120 54693780
SGTC_1550 gossypolone 36.6 µM -0.383058230690824 0.36433367719795 no 2166 0.350838294453902 3070 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2233 sulbentine 40.3845 µM -0.383773686196143 0.364092666839907 no 2167 0.350573096389345 3132 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1270 0831-1170 17.3 µM -0.38489144059397 0.363716244538341 no 2168 0.350158923865026 3109 6764716
SGTC_1527 coumarin 137 µM -0.386943286582471 0.363025593923534 no 2169 0.349399097180286 3255 323 A hepatotoxic, DNA x-linker.
SGTC_97 0535-0701 19.132 µM -0.388441336797236 0.362521631807194 no 2170 0.348844729356775 3108 2832013 YGL099W LSG1
SGTC_587 k089-0003 57 µM -0.389419070538459 0.362192838773464 no 2171 0.348483083489412 3155 9659696
SGTC_3028 9087778 49.47 µM -0.390028389997899 0.361987987766246 no 2172 0.348257776953953 3092 17217395
SGTC_939 1165-0479 45.3 µM -0.390087902476303 0.36196798200352 no 2173 0.348235774042143 3211 1377347
SGTC_1737 st035557 69.7 µM -0.390089118487998 0.36196757323198 no 2174 0.348235324464477 3113 5716916
SGTC_1363 1636-0063 10.4 µM -0.390309738425754 0.361893412775333 no 2175 0.34815376151156 3111 6072185
SGTC_3332 9141069 11.198 µM -0.390617861702394 0.36178984712138 no 2176 0.348039860423225 3065 17332883
SGTC_1335 1486-0900 202 µM -0.392721432555542 0.361083070736862 no 2177 0.347262619523648 3050 X1335
SGTC_576 1073-0113 22.7 µM -0.392824986656803 0.361048289933987 no 2178 0.347224374239479 3233 5439563
SGTC_2416 tofa 880 nM -0.393634584064472 0.360776409394593 no 2179 0.346925422035351 3084 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2746 daunorubicin 9.88 µM -0.394169261529753 0.360596891554228 no 2180 0.346728039077381 3136 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1696 st025591 34.7925 µM -0.394555445835143 0.360467249362973 no 2181 0.346585500118334 3095 2787147
SGTC_234 nsc-17383 10.7 µM -0.394753288383927 0.360400839769941 no 2182 0.346512485699723 3236 408974
SGTC_3120 9124077 49.47 µM -0.394991017884656 0.360321046937543 no 2183 0.346424758417928 3140 18774327 YGL155W CDC43
SGTC_997 3996-0078 137 µM -0.395799095742285 0.360049864760164 no 2184 0.346126621978935 3139 735687
SGTC_3189 9110682 49.47 µM -0.398676284823115 0.359084883812865 no 2185 0.345065872102149 3202 17122418
SGTC_3134 9127454 49.47 µM -0.399559772239272 0.358788750816137 no 2186 0.344740395398671 3227 24262820
SGTC_785 1270-0111 65.3 µM -0.400514476666417 0.358468842242749 no 2187 0.344388811497779 3079 6741994
SGTC_1612 st002233 45.4 µM -0.402634967573678 0.357758649837314 no 2188 0.34360839083792 3200 1035021
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.403134298985835 0.3575914858249 no 2189 0.343424714812894 3062 23665772 A membrane-active detergent.
SGTC_1575 cyproterone acetate 48 µM -0.404042202772762 0.357287611722323 no 2190 0.34309084267087 3146 9880 An androgen receptor antagonist and liver toxin.
SGTC_3330 9141424 71.43 µM -0.404089665798261 0.357271728402461 no 2191 0.343073392004689 3234 27261020
SGTC_2639 lactacystin 53 µM -0.405724157856922 0.356724902952229 no 2192 0.342472644970543 3262 3870 A proteasome inhibitor.
SGTC_660 4031-1742 102 µM -0.406832080284545 0.356354410632706 no 2193 0.342065661601315 3160 6738706
SGTC_787 4152-0075 138 µM -0.407015649632578 0.35629303761556 no 2194 0.34199824707867 3152 9566539
SGTC_1773 st048542 73.5835 µM -0.408101745950957 0.355929997600822 no 2195 0.34159948913822 3112 3237138
SGTC_1026 k007-1105 30.6 µM -0.40852893229263 0.35578724148762 no 2196 0.341442696984318 3131 7066794
SGTC_3127 9126946 49.47 µM -0.408893270853001 0.355665503672909 no 2197 0.341308993756485 3157 27243249
SGTC_678 1218-2179 85.9 µM -0.41007411702662 0.355271044321282 no 2198 0.34087578941915 3194 6820081 YOR116C RPO31
SGTC_1764 st044502 93.5 µM -0.410174781393315 0.355237424751669 no 2199 0.340838869459543 3236 8407
SGTC_1307 1187-1599 12.2 µM -0.410428858753197 0.355152573802892 no 2200 0.340745690078861 3098 1538471
SGTC_373 0844-0104 25.9 µM -0.412798974340875 0.354361403244546 no 2201 0.339876951484191 3262 5375804
SGTC_2041 5107442 45.335 µM -0.413732542166753 0.354049940303143 no 2202 0.33953499593306 3278 793005
SGTC_3163 9099914 49.47 µM -0.415475617064912 0.353468665816352 no 2203 0.338896880557794 3212 16268368
SGTC_1511 0906-3109 28.5 µM -0.416749844113035 0.353043957091069 no 2204 0.338430696026535 3153 2882180
SGTC_1851 st056236 18.9 µM -0.416896256803595 0.352995168436826 no 2205 0.338377145800372 3304 5393171
SGTC_2552 juarezic acid 87.02 µM -0.417448117505931 0.352811295306549 no 2206 0.338175332946288 3117 1549512
SGTC_1153 4055-0057 267 µM -0.417628671922411 0.352751144278904 no 2207 0.338109315138617 3138 882706
SGTC_1284 0929-0043 16 µM -0.417633558342394 0.352749516437536 no 2208 0.338107528540143 3187 1239883
SGTC_1988 st071872 53.4 µM -0.418050145753869 0.352610746177384 no 2209 0.337955227077243 3261 16414116
SGTC_2963 9082507 9 µM -0.425533143466557 0.350121425899673 no 2210 0.335224032934607 3281 16459611
SGTC_2789 5281112 71.43 µM -0.425631933744977 0.350088604730085 no 2211 0.335188033601221 3171 765948
SGTC_1210 3013-0140 750 nM -0.42622985385775 0.349889981181239 no 2212 0.334970182883788 3254 905973
SGTC_1131 3454-3128 32.3 µM -0.427041840180318 0.349620312575744 no 2213 0.334674426565206 3284 710982
SGTC_2285 7945142 200 µM -0.428517974299391 0.349130268380718 no 2214 0.334137025092979 3257 2970608
SGTC_2975 9084847 53.72 µM -0.428569426297799 0.349113191974815 no 2215 0.334118299598838 3222 27211724
SGTC_2183 6420625 130.508 µM -0.428578728886199 0.349110104570973 no 2216 0.334114914049156 3240 2897619
SGTC_646 4092-0839 27.3 µM -0.431876051834038 0.348016397978111 no 2217 0.332915750579302 3313 877796
SGTC_541 4513-1321 94 µM -0.431953781172293 0.347990630724448 no 2218 0.332887502682965 3178 747515
SGTC_1387 3342-1166 1.8 µM -0.433359724124267 0.347524682302091 no 2219 0.332376727793411 3203 3418228
SGTC_2882 9058044 58.44 µM -0.433515541037046 0.347473056641723 no 2220 0.332320139108201 3233 18076804
SGTC_3273 9137859 49.47 µM -0.433797577947092 0.347379618642593 no 2221 0.33221772029613 3256 2377234
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.434474264151022 0.347155472320673 no 2222 0.331972039747781 3144 803109
SGTC_279 1273-0055 2.93 µM -0.434962428967404 0.346993805229015 no 2223 0.331794849407137 3226 2847562
SGTC_131 0141-0277 33.849 µM -0.435067005274275 0.346959175982231 no 2224 0.331756895988646 3295 1547771
SGTC_1721 st082152 9.2685 µM -0.436391289337461 0.346520765137431 no 2225 0.331276428903211 3191 5296051
SGTC_35 0133-0054 64.071 µM -0.441738890170849 0.344752510831389 no 2226 0.329339082029086 3202 99677
SGTC_782 0083-0095 30.5 µM -0.441904364292818 0.344697848460431 no 2227 0.329279206187544 3149 3591729 An indicator and reagent.
SGTC_1702 st027038 51 µM -0.443201622403214 0.344269427384439 no 2228 0.328809952748304 3242 5521182
SGTC_1904 st060225 78 µM -0.445190453488818 0.343613001523062 no 2229 0.328091062554453 3274 66595
SGTC_106 0092-0003 11.579 µM -0.445532451450524 0.343500170440838 no 2230 0.327967506760328 3226 1072148
SGTC_1382 3002-2117 298 µM -0.445830590184752 0.343401820657132 no 2231 0.327859811628265 3338 1497314
SGTC_731 3966-0296 387 µM -0.446341674126314 0.343233249336357 no 2232 0.327675228691296 3176 660956
SGTC_381 3461-2219 42.7 µM -0.446604042049262 0.343146724377859 no 2233 0.32758048831563 3270 2883159
SGTC_3355 9151058 44.0485 µM -0.446813774333689 0.343077563767578 no 2234 0.327504762515557 3293 17015728
SGTC_3329 9141233 27.5565 µM -0.447196034923632 0.342951524328058 no 2235 0.327366762014196 3313 4909101 YNL103W MET4
SGTC_2400 5203494 178.7 µM -0.447350429831555 0.342900621999516 no 2236 0.327311030350659 3259 6777674
SGTC_759 3486-0358 89.3 µM -0.450325605839546 0.341920296554937 no 2237 0.326237839205405 3349 875103
SGTC_453 enantio-paf c16 10 µM -0.450947841786239 0.341715403197384 no 2238 0.326013570685873 3291 13871343 A lipid and platelet activating factor
SGTC_992 3909-8734 162 µM -0.452539537581345 0.341191492930097 no 2239 0.32544017245572 3224 4288319
SGTC_1241 0364-0022 50.8 µM -0.453436411654728 0.340896419515656 no 2240 0.325117261097318 3213 4563895
SGTC_1364 1653-0028 37.6 µM -0.453504480879747 0.340874028571254 no 2241 0.325092758749405 3235 5718652
SGTC_2805 7950783 58.44 µM -0.453899877201615 0.340743976519443 no 2242 0.32495044598007 3281 1178958 YDL195W SEC31
SGTC_3144 9087057 49.47 µM -0.45436025295286 0.340592575563471 no 2243 0.324784777711246 3304 17249618
SGTC_61 0978-8327 98.565 µM -0.455506896856262 0.340215597481557 no 2244 0.324372303471641 3301 6150059 YHR072W ERG7
SGTC_2113 5491891 107.031 µM -0.455531075216636 0.340207650164506 no 2245 0.324363608275312 3245 789979
SGTC_1002 4049-0206 172 µM -0.456321105265608 0.339948009952566 no 2246 0.324079544683557 3204 4662749
SGTC_635 k038-0028 24.7 µM -0.456560976962226 0.339869192094956 no 2247 0.323993316555513 3214 4035102
SGTC_200 k038-0079 37.545 µM -0.456571628973679 0.33986569218311 no 2248 0.323989487631545 3196 3436683
SGTC_3153 9100258 49.47 µM -0.46201401899294 0.338079307131233 no 2249 0.322035633596832 3198 25236848
SGTC_1545 lovastatin 49.4 µM -0.462609604150895 0.337884035242117 no 2250 0.321822111626987 3288 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2919 7978188 46.38 µM -0.462887646615527 0.337792889613082 no 2251 0.321722451350055 3378 2980291
SGTC_791 1348-1292 225 µM -0.462948235725044 0.337773029043854 no 2252 0.321700735766857 3238 5437054
SGTC_3088 9117578 49.47 µM -0.465615749072439 0.33689909037938 no 2253 0.320745283948469 3332 678341
SGTC_613 3914-0030 117 µM -0.466221269788664 0.336700830235617 no 2254 0.320528563080683 3139 1145395
SGTC_3252 9135871 49.47 µM -0.467313657536759 0.336343274446136 no 2255 0.320137743247423 3342 17682838
SGTC_3070 9117005 49.47 µM -0.467775771008794 0.336192061915387 no 2256 0.319972474503279 3321 8779016
SGTC_3131 9127911 49.47 µM -0.46852951297264 0.335945479731246 no 2257 0.319702985364912 3426 45595681
SGTC_1444 4112-3581 28 µM -0.469528668075913 0.335618720928689 no 2258 0.319345899126924 3268 2877249
SGTC_2536 dehydroabietamide 32.04 µM -0.470533567150913 0.335290208978436 no 2259 0.318986928990056 3363 3983547
SGTC_2063 5246145 200 µM -0.471986732375147 0.334815376909903 no 2260 0.318468129378577 3335 711240
SGTC_555 4296-0685 37 µM -0.472557700802865 0.334628881111435 no 2261 0.31826438323023 3294 2908540 YHR072W ERG7
SGTC_907 3448-6986 75.5 µM -0.473459445418434 0.3343344267627 no 2262 0.317942713854674 3381 590582
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.473463729704996 0.334333028021214 no 2263 0.317941185896113 3293 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1972 st070201 17.4 µM -0.473573461100678 0.33429720350423 no 2264 0.317902052075968 3343 2829099
SGTC_1498 4478-3555 97.6 µM -0.475071405455375 0.333808313713326 no 2265 0.317368039426954 3305 3437919
SGTC_244 nsc-207895 1.295 µM -0.475285837915688 0.333738351630095 no 2266 0.317291625962075 3216 42640
SGTC_2861 9024595 19.48 µM -0.475621286394005 0.333628917694093 no 2267 0.317172103801773 3238 16482810
SGTC_2518 prenyletin 46.28 µM -0.478495226002448 0.332691928309329 no 2268 0.316148885676492 3305 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1581 himbacine 57.9 µM -0.479290673542969 0.33243277310448 no 2269 0.315865928060923 3233 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1569 carminic acid 40.6 µM -0.479330160485856 0.332419910423506 no 2270 0.315851884523975 3370 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3290 9121031 71.43 µM -0.479618114654139 0.332326116711427 no 2271 0.315749481620197 3266 17014854
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.480054952639093 0.332183847948842 no 2272 0.315594159323178 3383 551469
SGTC_2393 9031399 185.94 µM -0.486582086389581 0.33006099034824 no 2273 0.313277260396536 3381 1526623 YDL150W RPC53
SGTC_1922 5578187 25 µM -0.486884766927839 0.329962679759028 no 2274 0.313169997299236 3425 1350412
SGTC_2770 toltrazuril 17.5 µM -0.486993475787214 0.329927374004972 no 2275 0.313131477209895 3359 68591 Kills coccidiodes.
SGTC_642 0335-0876 158 µM -0.487846926720605 0.32965024843335 no 2276 0.312829134773835 3297 6812350
SGTC_2365 9042475 200 µM -0.487941798287348 0.329619448290354 no 2277 0.312795533463646 3352 6464479
SGTC_1646 st011709 75.6 µM -0.489227963665012 0.329202007596797 no 2278 0.312340157069714 3355 5757843
SGTC_392 N-ethylmaleimide 8.33 µM -0.48997336313795 0.328960176476128 no 2279 0.312076373930199 3245 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_572 0960-0087 17.7 µM -0.492523317492291 0.328133432540972 no 2280 0.311174721121646 3291 6796365
SGTC_590 k048-0076 22.4 µM -0.493146711357912 0.327931444147526 no 2281 0.310954463734098 3354 6832814
SGTC_2828 7998861 71.43 µM -0.493547939156548 0.327801467301421 no 2282 0.31081273781965 3334 2988188
SGTC_860 0443-0016 25.1 µM -0.493829585132852 0.32771024117744 no 2283 0.310713268619855 3332 5337942
SGTC_1077 5-fluorocytosine 377 nM -0.494845080683261 0.32738140399795 no 2284 0.310354739912079 3337 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1385 3091-4834 14.1 µM -0.495085712459526 0.327303502370155 no 2285 0.310269809354 3340 4072814
SGTC_575 k072-0246 11.9 µM -0.497043497880145 0.326669972787739 no 2286 0.309579188814447 3327 6796779
SGTC_2000 st075254 36.4 µM -0.497927314484732 0.326384137669063 no 2287 0.309267637157348 3343 17234175
SGTC_1084 voriconazole 435 nM -0.502493840017251 0.324908904587271 no 2288 0.30766009220171 3393 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_209 4077-0173 175.592 µM -0.503765954004591 0.324498430643212 no 2289 0.307212927528875 3320 15993494
SGTC_2608 thymoquinone 42.66 µM -0.504818755088723 0.324158883693008 no 2290 0.306843070828897 3366 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2469 5655019 90.81 µM -0.505207638415368 0.324033498911274 no 2291 0.306706502964686 3397 2788239
SGTC_961 1252-1571 372 µM -0.505414852142396 0.323966696668384 no 2292 0.306633744700513 3433 6813498
SGTC_2809 7964133 12.99 µM -0.506638511064839 0.323572325119507 no 2293 0.306204240859127 3300 1253665
SGTC_2053 5265679 138 µM -0.506800205100134 0.323520227751777 no 2294 0.306147506211663 3284 764595
SGTC_393 acivicin 6.25 µM -0.510124054448143 0.322450060410282 no 2295 0.304982277006573 3246 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2869 9037858 32.47 µM -0.51032841099073 0.322384312364084 no 2296 0.304910700830134 3332 27187042
SGTC_854 0422-0053 192 µM -0.511110268630011 0.322132815017328 no 2297 0.304636922982368 3380 3596728
SGTC_2015 5119600 184 µM -0.51126144420719 0.322084196300866 no 2298 0.30458399945984 3413 2828786
SGTC_1617 st002906 78 µM -0.511726698038974 0.321934587771623 no 2299 0.304421149139437 3367 5150859
SGTC_2366 9070441 60.58 µM -0.51251462869977 0.321681284064102 no 2300 0.304145442402672 3292 6837235
SGTC_1010 4112-3296 15.2 µM -0.512645449056001 0.321639235994429 no 2301 0.30409967750487 3432 704384
SGTC_3310 9130229 44.1445 µM -0.512921333237656 0.321550569232011 no 2302 0.304003174976637 3378 7761258
SGTC_1225 1216-0074 20.6 µM -0.514913600400522 0.320910574006989 no 2303 0.303306698296753 3319 4241466
SGTC_1867 st057372 64 µM -0.515923675510214 0.32058630084186 no 2304 0.302953858816799 3392 688837
SGTC_862 0452-0056 10.2 µM -0.519048493935359 0.319583980965025 no 2305 0.301863462283066 3380 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2011 4012611 177 µM -0.519299076279924 0.319503660845181 no 2306 0.301776098716029 3295 2049887
SGTC_3062 9077494 49.47 µM -0.519545521258925 0.319424675149398 no 2307 0.301690188696638 3375 16459633
SGTC_1004 4084-0029 199 µM -0.522086291500665 0.318610835636914 no 2308 0.300805125345697 3421 716894 YLR208W SEC13
SGTC_902 1120-0002 2.07 µM -0.523402351325087 0.318189629149356 no 2309 0.300347144128996 3387 3280475
SGTC_807 1315-0151 48 µM -0.524330870907874 0.317892596715214 no 2310 0.300024214381692 3494 4011080
SGTC_1233 0325-0408 14.2 µM -0.525156285442838 0.31762864580901 no 2311 0.299737275493038 3411 12874
SGTC_2274 7947094 46.08 µM -0.527972217784352 0.316728865502033 no 2312 0.29875930943592 3422 2971028
SGTC_2512 diallyl trisulfide 49.23 µM -0.528412609664861 0.316588244048401 no 2313 0.298606493705981 3405 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2438 5259590 200 µM -0.528570312913119 0.316537894296267 no 2314 0.298551779414519 3382 1201127
SGTC_1607 st000305 50.6 µM -0.528623705870443 0.316520848352589 no 2315 0.298533256049309 3423 5457690
SGTC_100 0086-0128 49.5915 µM -0.529559293998032 0.316222220873281 no 2316 0.298208761779362 3362 93297
SGTC_2407 paclitaxel 400 µM -0.530280691678889 0.315992041986719 no 2317 0.297958665889073 3453 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2685 mycophenolic acid 18.85 µM -0.532605039512344 0.315250889602297 no 2318 0.297153506446993 3349 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_811 0416-0114 265 µM -0.533690743174915 0.314904951438438 no 2319 0.296777757326741 3433 6612453
SGTC_655 k060-0012 42 µM -0.53421173875346 0.314739004042287 no 2320 0.296597524220076 3332 5994525
SGTC_1846 st056244 14.8 µM -0.536928531047259 0.313874258700124 no 2321 0.29565849112615 3368 5393182
SGTC_175 3793-3120 23.7 µM -0.537721589783312 0.313622023281457 no 2322 0.295384635891812 3324 5322297
SGTC_2247 cerulenin 830 nM -0.538069553455411 0.313511379568765 no 2323 0.295264515593804 3506 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2026 5148700 152 µM -0.538677256225576 0.313318185584243 no 2324 0.295054784880149 3329 79838
SGTC_1208 2323-2347 50.3 µM -0.540137683941508 0.312854112457516 no 2325 0.294551042079164 3431 5412760
SGTC_3274 9138298 49.47 µM -0.540287181241228 0.312806624128955 no 2326 0.294499498633324 3396 17015756
SGTC_69 0096-0274 206.684 µM -0.541610059990252 0.312386542610382 no 2327 0.294043580062165 3574 6741392
SGTC_1951 sophoraflavanone G 9.2 µM -0.541731237537661 0.312348074731493 no 2328 0.294001833599356 3350 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3148 9097893 49.47 µM -0.546652930940356 0.310787412697598 no 2329 0.292308598594989 3311 17174100
SGTC_89 0302-0250 142.109 µM -0.546873574033338 0.310717526465806 no 2330 0.292232795973949 3479 4203518 YLR208W SEC13
SGTC_3244 9134489 49.47 µM -0.548163547086436 0.310309078666784 no 2331 0.291789804847509 3416 16584271
SGTC_2487 5918373 44.05 µM -0.55044582602645 0.309587007339868 no 2332 0.291006812240747 3504 2876279
SGTC_308 4092-1169 104 µM -0.551606908107308 0.309219943831597 no 2333 0.29060885121442 3405 2268590 YDL196W YDL196W
SGTC_1024 4507-0395 26 µM -0.552078931195416 0.309070773249446 no 2334 0.29044713806935 3502 4201836
SGTC_685 1278-0033 54.9 µM -0.552132875349145 0.309053727610774 no 2335 0.290428659709239 3487 3590572
SGTC_570 0987-0065 62.6 µM -0.552278934201298 0.3090075770101 no 2336 0.29037863057988 3346 3104428
SGTC_1841 st054148 70 µM -0.553072240899274 0.308756966467884 no 2337 0.290106971961239 3410 675442
SGTC_386 1509-0011 3.07 µM -0.553340356724804 0.308672287127312 no 2338 0.290015185763752 3442 3107280
SGTC_2180 6301957 200 µM -0.554791740361999 0.308214071578682 no 2339 0.289518558672096 3438 845462
SGTC_2488 5268135 45.7 µM -0.556163759376778 0.307781186806963 no 2340 0.289049455693636 3436 1270356 YLR208W SEC13
SGTC_1499 4480-0877 67.3 µM -0.557640693681945 0.307315499146214 no 2341 0.288544881364047 3419 2861909
SGTC_2448 5185112 27.17 µM -0.55817801070348 0.307146156339244 no 2342 0.288361417391584 3441 5718189
SGTC_708 3448-5400 146 µM -0.558842727422552 0.306936718679913 no 2343 0.288134529618962 3446 3462195
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.560221979383595 0.306502347642074 no 2344 0.28766401842091 3588 6728940
SGTC_1807 st050092 58.9 µM -0.564084458169762 0.305287375483684 no 2345 0.286348327331464 3384 5008496
SGTC_1982 st072467 71.9 µM -0.566266340241873 0.304601993656496 no 2346 0.285606369185131 3329 3163533
SGTC_2343 7990716 14.84 µM -0.569842394170101 0.30348015168199 no 2347 0.284392299415754 3416 6456862
SGTC_958 1222-0007 33 µM -0.570129412963286 0.303390191228038 no 2348 0.284294963582786 3536 7312461
SGTC_1264 0783-0040 158 µM -0.570996346458502 0.303118540178756 no 2349 0.284001059721077 3398 2855798
SGTC_3302 9125395 16.351 µM -0.571183088280661 0.303060039424864 no 2350 0.283937770390231 3377 17599668
SGTC_841 0251-0215 91.2 µM -0.571526411422413 0.302952499502948 no 2351 0.283821431145529 3454 3888614
SGTC_1547 harmine 94.2 µM -0.571856502311471 0.302849120458373 no 2352 0.283709597334332 3509 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2725 haloperidol 53.21 µM -0.572423836499722 0.302671477622126 no 2353 0.283517435520316 3440 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1303 1160-0052 261 µM -0.572925654361824 0.302514388081322 no 2354 0.283347516748999 3484 3562476
SGTC_1602 st001878 87.6 µM -0.573046982725647 0.302476412822357 no 2355 0.283306441512305 3508 595405 YLR310C CDC25
SGTC_2977 9011197 71.43 µM -0.573871052954644 0.302218538945072 no 2356 0.283027531391888 3530 2704722
SGTC_1124 fisetin 1.16336 µM -0.574425579914627 0.302045068005978 no 2357 0.28283992356825 3423 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2193 5925765 200 µM -0.574939345166971 0.301884388341922 no 2358 0.282666159587374 3477 877370
SGTC_17 0960-0276 49.807 µM -0.575527279559514 0.301700559480855 no 2359 0.282467373334818 3485 6821114
SGTC_208 k072-0098 12.366 µM -0.575585058389883 0.301682496548115 no 2360 0.28244784138715 3484 5948901
SGTC_913 3487-1245 167 µM -0.576607800866765 0.301362845286824 no 2361 0.282102214134258 3403 4016153
SGTC_2350 9023895 38.85 µM -0.579294429004638 0.300523885093306 no 2362 0.281195261952985 3478 2997209
SGTC_1635 st007035 42.4 µM -0.58101251646824 0.299987927104314 no 2363 0.280616008936649 3507 3716403
SGTC_1665 st014639 11.4 µM -0.58144438137827 0.299853274745532 no 2364 0.280470496575725 3534 981133 YIL048W NEO1
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.583023334552128 0.299361201617249 no 2365 0.279938795935989 3483 442882
SGTC_1809 st050081 57.6 µM -0.583538718532603 0.299200664005848 no 2366 0.279765350111901 3571 5036894
SGTC_2058 5236698 133 µM -0.583658940401805 0.29916322156313 no 2367 0.279724898495014 3433 766665
SGTC_2459 5811157 9.22 µM -0.584653916395791 0.298853423403857 no 2368 0.279390223236728 3480 2870684 YBR192W RIM2
SGTC_2567 aureobasidin a 60 nM -0.584744237204132 0.298825308114096 no 2369 0.279359852096257 3553 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1196 1588-0294 184 µM -0.586867370960014 0.29816476016453 no 2370 0.27864639265799 3467 6144269
SGTC_338 4055-0136 114 µM -0.58687580467908 0.298162137598188 no 2371 0.278643560354934 3460 2900563
SGTC_3143 9086658 49.47 µM -0.588866672379383 0.297543347585028 no 2372 0.277975358092911 3492 25236626
SGTC_1204 4049-0315 18.3 µM -0.589786919257254 0.297257520026083 no 2373 0.277666756720484 3555 588402
SGTC_2007 4011539 71.82 µM -0.59065235966593 0.296988829838389 no 2374 0.27737668727677 3507 45595301
SGTC_302 1094-0063 18.9 µM -0.590699550499932 0.296974181863606 no 2375 0.277360874597501 3435 5440289
SGTC_707 0865-0008 204 µM -0.591831613988149 0.296622889904949 no 2376 0.276981675541898 3499 723043
SGTC_919 tnp00227 403.569 nM -0.592179128078917 0.296515090591245 no 2377 0.276865322213395 3474 1269246 A methoxyflavone. YNL221C POP1
SGTC_1718 roemerine 11.9335 µM -0.592488874342837 0.296419022039212 no 2378 0.276761634343168 3502 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2759 disulfiram 3.38 µM -0.592511493376855 0.296412007250165 no 2379 0.276754063344389 3449 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2582 agaric acid 100 µM -0.592604037514121 0.296383307542116 no 2380 0.276723088208821 3487 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1173 0443-0020 122 µM -0.592647348120225 0.29636987653191 no 2381 0.276708592445666 3474 5331295
SGTC_3348 9149464 3.537 µM -0.593122897392423 0.296222422762357 no 2382 0.276549453837048 3513 1951442
SGTC_2735 sertaconazole 140 nM -0.594707463765942 0.295731338625828 no 2383 0.276019515928647 3534 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3123 9126162 49.47 µM -0.594852760340234 0.295686327470085 no 2384 0.27597094832248 3521 25239884
SGTC_504 lovastatin 124 µM -0.595350300508361 0.29553221928118 no 2385 0.275804669698726 3455 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2009 4012297 12.05 µM -0.597557763424753 0.294848925152662 no 2386 0.275067526801877 3489 45595307
SGTC_1358 1509-0022 2.48 µM -0.597951757265413 0.294727045629719 no 2387 0.2749360617091 3512 3258434
SGTC_2088 5278280 127.392 µM -0.598019408980654 0.294706120333333 no 2388 0.274913491275617 3545 791502
SGTC_2781 5567276 71.43 µM -0.598401883208246 0.294587830433401 no 2389 0.274785904752582 3521 2853274
SGTC_2682 pyrogallin 40.03 µM -0.599243529123044 0.294327607159923 no 2390 0.274505249648405 3532 822798 An ATP competetive kinase inhibitor.
SGTC_664 1222-0054 14.9 µM -0.599368528600839 0.294288968402907 no 2391 0.274463579409949 3527 6813991
SGTC_983 1491-0821 12.2 µM -0.599875472236672 0.294132290394705 no 2392 0.274294615014699 3510 46495113
SGTC_2990 9074105 71.4286 µM -0.599947281874974 0.294110099740678 no 2393 0.274270685004175 3497 6502001
SGTC_1408 3909-7976 48.8 µM -0.60009165170255 0.29406548883852 no 2394 0.274222577987644 3505 24152374
SGTC_1054 3429-0080 167 µM -0.600102723633497 0.294062067693027 no 2395 0.274218888763003 3545 1162877
SGTC_2477 5967686 25.23 µM -0.601581249063377 0.293605379534074 no 2396 0.273726456752549 3486 776118
SGTC_1266 0828-0227 32.9 µM -0.60172327598809 0.293561527431816 no 2397 0.273679176846119 3451 3913820
SGTC_1357 1503-1303 39.5 µM -0.601755587644828 0.293551551337975 no 2398 0.273668421054662 3518 292895
SGTC_3176 9106582 49.47 µM -0.601772492285239 0.293546332160904 no 2399 0.273662793980322 3447 17018027
SGTC_1050 3232-1156 69.3 µM -0.601801989884136 0.293537225108141 no 2400 0.2736529752051 3443 700529
SGTC_389 tpck 16.7 µM -0.60198266300516 0.293481447163969 no 2401 0.273592838901227 3490 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1818 st052136 56.3 µM -0.602083849131732 0.293450210826273 no 2402 0.273559162372961 3479 674169
SGTC_370 0180-0345 38.7 µM -0.604626764964854 0.292665714357876 no 2403 0.27271350933948 3458 3989527
SGTC_296 1222-0039 74.9 µM -0.607868965838184 0.291666901804838 no 2404 0.271637192010449 3489 5984176
SGTC_1351 1496-0003 46.5 µM -0.607968696135834 0.291636203474549 no 2405 0.27160411798208 3542 3891978
SGTC_558 k064-0027 21.3 µM -0.609510339101137 0.291161856702045 no 2406 0.271093110878411 3515 5088526
SGTC_2806 7952793 58.44 µM -0.611310008273854 0.290608574265844 no 2407 0.270497183252823 3538 2972490
SGTC_1729 st035615 45.989 µM -0.61258954479488 0.290215498568413 no 2408 0.27007388655011 3468 17385451
SGTC_2212 7123476 200 µM -0.613245079574072 0.290014213758414 no 2409 0.269857150772027 3494 1085715
SGTC_1647 st011722 22.4 µM -0.615397485248606 0.289353768885483 no 2410 0.269146125878215 3554 2854783
SGTC_2528 xanthyletin 44.79 µM -0.616058440848627 0.28915110296683 no 2411 0.26892797483974 3537 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3198 9112019 49.47 µM -0.616083701866591 0.289143358615981 no 2412 0.268919639101363 3553 45595555
SGTC_1788 fluconazole 20 µM -0.616300168067171 0.289076999881505 no 2413 0.268848213981015 3526 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2149 5554786 194.827 µM -0.617128645296706 0.288823092469802 no 2414 0.268574937926796 3526 745063 YPR165W RHO1
SGTC_2857 9024691 58.44 µM -0.617151054141634 0.288816226181441 no 2415 0.268567548232155 3535 16478292
SGTC_2130 NSC 7 2.4545 µM -0.619852243895129 0.287989118781106 no 2416 0.267677534636581 3538 21448
SGTC_622 1348-1566 26.3 µM -0.622108917725137 0.28729898112266 no 2417 0.266935125753251 3536 7340407
SGTC_976 1348-1067 47.6 µM -0.623245254729656 0.286951762194999 no 2418 0.266561683541698 3592 5310671 YGL099W LSG1
SGTC_1318 1280-3875 124 µM -0.624323506516725 0.286622475702904 no 2419 0.26620757472654 3548 373245
SGTC_533 1222-0222 6.71 µM -0.624909449273645 0.286443610275977 no 2420 0.266015245103594 3598 3982874
SGTC_2994 9053520 71.4286 µM -0.625013378077475 0.286411890405044 no 2421 0.265981138904193 3534 4647384
SGTC_2376 9072922 81.32 µM -0.625036460226704 0.286404845781668 no 2422 0.265973564361718 3591 17087968
SGTC_3082 9117008 49.47 µM -0.628009851535434 0.285498061366098 no 2423 0.264998743184927 3510 41448529
SGTC_879 0831-1030 162 µM -0.628603526275117 0.285317174344958 no 2424 0.264804325588731 3588 1549252
SGTC_1709 st033179 39.1045 µM -0.629692870321796 0.284985403687575 no 2425 0.264447774080958 3552 573381
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.630474489124904 0.284747467257112 no 2426 0.264192094279166 3484 641818 YHR062C RPP1
SGTC_578 3460-0051 92 µM -0.631016032274571 0.28458266905982 no 2427 0.264015020864944 3623 2876744
SGTC_1271 0832-2808 169 µM -0.631057998935603 0.284569899993852 no 2428 0.264001301159852 3595 3663794
SGTC_1981 st071826 47 µM -0.634183669115539 0.283619631939047 no 2429 0.262980482022755 3532 11838600
SGTC_744 1594-0068 283 µM -0.636023947787997 0.283060861264103 no 2430 0.262380406660908 3584 668392
SGTC_1692 fluoroquinolonic acid 71 µM -0.637314276111809 0.282669389435253 no 2431 0.261960076867294 3593 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3288 9119690 36.221 µM -0.637974671164229 0.282469133340173 no 2432 0.261745084088866 3533 17595618 YKL019W RAM2
SGTC_825 1988-2224 89.6 µM -0.63850153466015 0.282309417872 no 2433 0.261573627687319 3571 1180859
SGTC_2325 6158266 200 µM -0.638734737932367 0.282238737592019 no 2434 0.261497755104639 3549 3623240
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.63885272675276 0.282202980262775 no 2435 0.261459371798551 3558 6312947
SGTC_483 fpl-64176 144 µM -0.639628080529715 0.281968058189899 no 2436 0.261207211064745 3598 3423
SGTC_1618 st003135 44.5 µM -0.639926163652787 0.281877767970406 no 2437 0.261110301670142 3531 1270615
SGTC_1472 k841-0093 193 µM -0.6404376183452 0.281722879365492 no 2438 0.260944066406283 3638 X1472
SGTC_1042 0350-0096 82 µM -0.640780057838722 0.28161919814994 no 2439 0.260832795635972 3575 3122515
SGTC_793 0488-0545 106 µM -0.641114584244938 0.281517930569997 no 2440 0.260724119682693 3541 292548
SGTC_2082 5219693 150 µM -0.641416019003038 0.281426695517259 no 2441 0.260626214011847 3588 2834649
SGTC_1792 st045773 43.6 µM -0.642118658568195 0.281214083486784 no 2442 0.260398070961305 3543 2919270
SGTC_723 4182-0001 115 µM -0.64239340470509 0.28113096902526 no 2443 0.260308890444647 3521 744821 YLR208W SEC13
SGTC_2361 9034121 116 µM -0.642541002025497 0.281086323718292 no 2444 0.260260987969795 3555 6496917
SGTC_1187 1391-0724 117 µM -0.643098600712885 0.28091769192251 no 2445 0.260080061208422 3597 6997986
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.643335741597445 0.280845989408446 no 2446 0.260003134608849 3549 77254
SGTC_967 1306-0166 352 µM -0.644381912736234 0.280529772135917 no 2447 0.259663905203897 3579 4437607
SGTC_371 0195-0006 7.36 µM -0.647278601732271 0.279655114694761 no 2448 0.258725823977439 3508 3928593
SGTC_1080 nisoldipine 24.4 µM -0.647282092607501 0.279654061421337 no 2449 0.258724694530555 3566 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1162 k048-0130 20.1 µM -0.649438473808389 0.279003802239298 no 2450 0.258027501336488 3588 6797406
SGTC_2434 5670830 169.91 µM -0.649676789004942 0.278931983175674 no 2451 0.257950509987871 3577 1549830
SGTC_680 0417-1641 114 µM -0.652483999621029 0.278086675120839 no 2452 0.25704449572944 3573 2835990
SGTC_2102 5377816 72.7585 µM -0.652735887709719 0.278010887646907 no 2453 0.256963281010996 3624 1379702
SGTC_2997 9067075 71.4286 µM -0.653345913803337 0.277827386252544 no 2454 0.256766649400319 3578 27209819
SGTC_3209 9113616 49.47 µM -0.653766074775473 0.277701032412826 no 2455 0.256631263171409 3631 16649353
SGTC_3183 9108214 49.47 µM -0.653836785470339 0.277679770541927 no 2456 0.256608482096482 3523 4974831
SGTC_2142 5622915 118.518 µM -0.654356388827705 0.277523556342767 no 2457 0.256441112246547 3580 5322196
SGTC_2158 5657123 3.6195 µM -0.657824829494223 0.2764819015869 no 2458 0.255325348823567 3591 2858827
SGTC_651 3253-0966 34.4 µM -0.658554002055643 0.276263157950978 no 2459 0.25509110437678 3612 781462
SGTC_752 1896-0090 130 µM -0.659060590253288 0.276111237150012 no 2460 0.2549284306735 3603 772567
SGTC_2904 7225135 42.03 µM -0.661194279095001 0.27547181543864 no 2461 0.254243864813642 3684 4446116
SGTC_1705 st027868 56.3335 µM -0.663400609048567 0.274811391671296 no 2462 0.253537007970586 3628 292948
SGTC_27 0485-0001 32.618 µM -0.666850554458247 0.273780281684117 no 2463 0.252433798559528 3562 2054479
SGTC_3297 9117502 71.43 µM -0.667023296046096 0.273728703506342 no 2464 0.252378626547241 3618 7453720
SGTC_276 colchicine 750 µM -0.668442040458018 0.273305268564188 no 2465 0.251925733723783 3656 2833 A microtubule depolymerizer.
SGTC_705 1124-0212 310 µM -0.668796418789661 0.273199552346536 no 2466 0.251812675753028 3626 9554485
SGTC_278 4092-0821 23.9 µM -0.668960267249367 0.273150680814754 no 2467 0.251760411934686 3617 877900
SGTC_1286 0929-0070 131 µM -0.669757223760545 0.272913032198603 no 2468 0.25150628319221 3681 1420408
SGTC_628 1636-0253 16 µM -0.670003380610188 0.272839650135696 no 2469 0.251427817570513 3605 4456143
SGTC_2588 indole-3-carbinol 100 µM -0.670789207560547 0.272605451996446 no 2470 0.251177411856046 3618 3712 Induces cell cycle arrest.
SGTC_2733 amorolfine 100 µM -0.670939849875251 0.272560567825951 no 2471 0.251129424377735 3636 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2067 5224629 34.075 µM -0.672379230284894 0.272131886729215 no 2472 0.250671150872252 3627 2835000
SGTC_1115 galangin 695.678 nM -0.673136776605896 0.271906406442267 no 2473 0.250430139414848 3671 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_44 0929-0055 61.211 µM -0.674857221424134 0.271394669171964 no 2474 0.249883240725534 3586 1379590
SGTC_1048 3161-0300 24.5 µM -0.675836215627966 0.271103686869133 no 2475 0.249572319193436 3655 2165101
SGTC_508 roscovitine 141 µM -0.676920941040173 0.270781460331831 no 2476 0.249228058359851 3670 160355 A CDKinase inhibitor.
SGTC_2119 5528445 120.635 µM -0.677216344643062 0.270693741415435 no 2477 0.249134349470233 3646 791935
SGTC_3027 9089541 49.47 µM -0.6779649300553 0.27047151553461 no 2478 0.248896964723967 3633 9943819
SGTC_2395 5646831 180.19 µM -0.677990066369066 0.270464055123335 no 2479 0.248888995809454 3651 6808628
SGTC_1540 guanosine 70.6 µM -0.679416775362397 0.270040779168275 no 2480 0.248436911846199 3592 6802 Guanosine is a purine nucleoside
SGTC_236 1509-0011 5.31 µM -0.680041850056668 0.26985543651231 no 2481 0.248238981210971 3722 3107280
SGTC_3037 9091026 49.47 µM -0.68109335968352 0.269543794180351 no 2482 0.2479062092478 3655 25236398 YIL048W NEO1
SGTC_3317 9138495 8.753 µM -0.681166622513176 0.269522087550511 no 2483 0.247883032585994 3637 17020139
SGTC_2267 7931562 200 µM -0.682035858574399 0.269264613384944 no 2484 0.247608138451042 3575 934880
SGTC_1224 0823-0416 294 µM -0.682208935832874 0.269213361348895 no 2485 0.247553422566597 3673 3598164
SGTC_671 0560-0003 407 µM -0.682488971436784 0.269130446926935 no 2486 0.247464907023067 3586 3238678
SGTC_48 0382-0018 55 µM -0.684914140878933 0.268412926337388 no 2487 0.246699051069929 3745 762596
SGTC_1376 2910-0861 41.3 µM -0.685327347076046 0.268290769437106 no 2488 0.246568689358666 3655 1112859
SGTC_637 1181-0519 7.26 µM -0.686462442755589 0.267955343033364 no 2489 0.246210769980477 3668 6252091 YGR060W ERG25
SGTC_3261 9137475 49.47 µM -0.687262144573635 0.267719154043074 no 2490 0.245958774669971 3534 17027690
SGTC_1666 st014829 29 µM -0.687446892354333 0.267664604387411 no 2491 0.245900578188544 3676 3858230
SGTC_206 4546-0025 72.014 µM -0.688358005065774 0.26739566615204 no 2492 0.245613681215756 3668 6620745 YIL048W NEO1
SGTC_1552 6-methylflavone 10.6 µM -0.688637116200858 0.267313306639022 no 2493 0.245525828910446 3623 689013
SGTC_1160 4092-0570 10.5 µM -0.688750006240554 0.267279998924711 no 2494 0.245490300726311 3654 4994975
SGTC_2032 5185112 25.99 µM -0.688886412060325 0.267239755776125 no 2495 0.245447375459814 3585 5718189
SGTC_816 0325-0417 81.3 µM -0.689903774675611 0.266939704694848 no 2496 0.245127350966921 3655 68101
SGTC_2887 9044784 58.44 µM -0.693759220585709 0.265804163341681 no 2497 0.243916610166243 3674 6465546
SGTC_361 000s-0510 1.45 µM -0.694695791716631 0.265528685895253 no 2498 0.243622982945627 3669 660
SGTC_602 3130-1533 38.1 µM -0.694781676742773 0.265503431437369 no 2499 0.243596066431436 3676 720941
SGTC_1863 st057641 20.1 µM -0.696483044088871 0.265003396342366 no 2500 0.243063186173522 3684 3921635
SGTC_1274 0865-0114 173 µM -0.699068568814064 0.264244422874373 no 2501 0.242254590068178 3679 870624
SGTC_1438 4092-1045 4 µM -0.700325707066917 0.263875793866315 no 2502 0.24186196050514 3667 1351342
SGTC_259 usnic acid 108.925 µM -0.703102389056532 0.263062521086659 no 2503 0.240995971713281 3758 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_815 1582-0027 36.9 µM -0.703342824264199 0.262992159427847 no 2504 0.240921064432328 3710 3128206
SGTC_2832 7992762 51.95 µM -0.703714727264977 0.262883343602348 no 2505 0.240805223478294 3622 2985177
SGTC_1027 k015-0025 8.67 µM -0.704065434951675 0.262780750449981 no 2506 0.240696012246188 3656 3598955
SGTC_933 2914-0560 114 µM -0.704708047423299 0.262592819017535 no 2507 0.240495971120849 3698 463887
SGTC_1336 1486-0901 104 µM -0.706040270617581 0.262203430778601 no 2508 0.240081547173256 3704 5006114
SGTC_3006 9075424 71.4286 µM -0.707579514241494 0.261753902318874 no 2509 0.239603209110474 3689 7465181
SGTC_2109 5483026 200 µM -0.709159149547077 0.261292989099401 no 2510 0.239112860229402 3710 759335
SGTC_2353 9059630 146.67 µM -0.70924603792007 0.261267648515447 no 2511 0.239085904347311 3721 4779114
SGTC_479 n-linoleoylglycine 10 µM -0.709325794944881 0.261244388867013 no 2512 0.239061162326781 3711 6433346 An anti-infammatory.
SGTC_2635 hydroquinidine 100 µM -0.711317462861623 0.260663901282131 no 2513 0.238443766290241 3663 442912 An experimental heart treatment.
SGTC_2208 7283366 200 µM -0.712769957329307 0.260240979123288 no 2514 0.237994059415609 3688 898663
SGTC_2394 5221648 200 µM -0.713908980251848 0.259909577874703 no 2515 0.237641731989952 3770 788586
SGTC_2323 6148992 148.28 µM -0.717029901623399 0.259002655539903 no 2516 0.236677823312829 3688 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2505 galangin 7.89 µM -0.717501340810854 0.25886580037217 no 2517 0.236532404696294 3638 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3328 9140624 29.0385 µM -0.718960823399308 0.258442361137227 no 2518 0.236082529258027 3709 4904392
SGTC_1033 k072-0102 21.3 µM -0.719737378419708 0.258217205803843 no 2519 0.235843353807034 3674 5965931
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.720091364733976 0.258114604319362 no 2520 0.235734371955878 3649 17037758
SGTC_3221 9128209 49.47 µM -0.722391932002751 0.2574483098062 no 2521 0.235026772910336 3742 16460723
SGTC_920 mycophenolic acid 780.421 nM -0.722529827257156 0.257408400733982 no 2522 0.234984396960688 3737 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_16 erodoxin 22.806 µM -0.7227390179792 0.257347863761087 no 2523 0.234920119592759 3730 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1934 st074720 32.6 µM -0.724169063504028 0.256934226130733 no 2524 0.234480974392827 3688 17250992
SGTC_2678 equilin 100 µM -0.724220517356416 0.256919349662941 no 2525 0.234465182167432 3724 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2020 4017018 200 µM -0.726066937972387 0.25638580462529 no 2526 0.233898868035138 3778 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2817 7995342 71.43 µM -0.72743485030939 0.255990902871515 no 2527 0.233479805979152 3709 18879975
SGTC_3022 9087993 49.47 µM -0.727681000091862 0.255919875749499 no 2528 0.233404441850023 3745 17173644
SGTC_1504 k297-0033 30 µM -0.728607101488218 0.255652739082828 no 2529 0.233121016634419 3634 4388117
SGTC_2478 5763493 32.33 µM -0.729177531776841 0.255488269290866 no 2530 0.232946536581676 3685 1365576 YLR208W SEC13
SGTC_3291 9121177 71.43 µM -0.730549903847252 0.255092805565996 no 2531 0.232527060349539 3714 17015612
SGTC_1946 st076057 65.1 µM -0.730918086531525 0.254986764276051 no 2532 0.23241459393744 3612 953009
SGTC_404 fumagillin 50 µM -0.731876914622145 0.254710717885198 no 2533 0.232121848886515 3716 12015870 A methionine aminopeptidase binder.
SGTC_629 3448-6466 76.7 µM -0.732269144038484 0.254597840241107 no 2534 0.232002154356023 3722 573744
SGTC_2525 harmine 47.85 µM -0.732623016739436 0.254496023562918 no 2535 0.231894194432403 3719 5280953 A monoamine oxidase inhibitor
SGTC_1868 st057644 42.7 µM -0.733870283406107 0.254137328684754 no 2536 0.231513899959507 3740 688665
SGTC_2570 licareol 100 µM -0.734194026637101 0.254044268430483 no 2537 0.231415246769639 3738 443158
SGTC_2418 pentamidine 31.67 µM -0.734376355948425 0.253991865592659 no 2538 0.231359696490003 3704 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2380 9035439 200 µM -0.734649699000477 0.25391331533636 no 2539 0.231276430983248 3816 6462575
SGTC_2549 cedrol 20.94 µM -0.735152023800632 0.253768996126816 no 2540 0.231123456864794 3675 6708665 A sedative which affects the nervous system.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.73590104058907 0.25355388168681 no 2541 0.230895461975342 3737 688761
SGTC_2023 5144124 124 µM -0.736495541840797 0.253383211669909 no 2542 0.230714589844947 3737 2830192
SGTC_3103 9120822 49.47 µM -0.736975423096627 0.253245490931179 no 2543 0.230568647657565 3784 17141819
SGTC_2793 7325131 81.82 µM -0.737296160561055 0.253153464691732 no 2544 0.230471133283084 3735 4176441
SGTC_665 3914-0008 307 µM -0.737350393356185 0.253137905915144 no 2545 0.230454647069999 3717 1069549
SGTC_2062 5245942 200 µM -0.737855071881409 0.252993143465623 no 2546 0.230301261593179 3809 1376160
SGTC_1539 benzyladenosine 56 µM -0.738169163824585 0.252903071042028 no 2547 0.230205829371241 3719 92208 A nucleotide analog.
SGTC_471 1-acyl-paf 4 µM -0.740033281336437 0.252368843954468 no 2548 0.229639900088305 3695 16759367
SGTC_2453 5731132 22.18 µM -0.740280824866665 0.252297946596309 no 2549 0.229564806762784 3757 1362040
SGTC_333 3486-0131 40.1 µM -0.74342618663515 0.251398018826761 no 2550 0.22861184749501 3802 6744690
SGTC_1151 3909-8316 15.3 µM -0.745005706394807 0.250946739028235 no 2551 0.228134135102006 3782 800431
SGTC_402 epigallocatechin gallate 10 µM -0.746623377550246 0.250485003868823 no 2552 0.227645466483259 3732 65064 An antioxidant.
SGTC_2830 7992007 71.43 µM -0.748141405745459 0.250052119808341 no 2553 0.227187434627184 3668 1952075
SGTC_3119 9125183 49.47 µM -0.748509389583 0.249947244576808 no 2554 0.227076481811014 3617 22695334
SGTC_2956 9076196 2.52 µM -0.748929482867182 0.249827546718355 no 2555 0.226949854544948 3776 16423868
SGTC_2506 ethyl hematommate 54.16 µM -0.749191501087241 0.249752904855915 no 2556 0.226870895468487 3827 3940691 An allergen.
SGTC_3243 9134147 49.47 µM -0.75105404981384 0.249222656848556 no 2557 0.226310064012007 3793 24282180
SGTC_1763 st044482 94.5 µM -0.75113445004231 0.249199781236777 no 2558 0.226285872370084 3781 88505
SGTC_2825 7998094 58.44 µM -0.751342303085999 0.249140647705334 no 2559 0.22622333819391 3750 2987815
SGTC_2205 7238770 200 µM -0.751693380325351 0.249040784297104 no 2560 0.226117736101481 3774 279867
SGTC_688 0527-0193 473 µM -0.755293129317206 0.24801807083066 no 2561 0.225036560131954 3784 4007154
SGTC_460 trequinsin 123 µM -0.755373266986122 0.247995328693672 no 2562 0.225012524356516 3804 5537 A vasodilator.
SGTC_1984 st072354 53.1 µM -0.75565780571927 0.24791458890582 no 2563 0.224927194109153 3692 5762938
SGTC_668 1682-0499 62.6 µM -0.756874578787806 0.247569479658403 no 2564 0.224562503345619 3787 682214
SGTC_1697 st025554 27.742 µM -0.758200214903769 0.247193786261606 no 2565 0.22416556630013 3732 1269519
SGTC_1965 Pectolinarigenin 58.4 µM -0.759333711433241 0.246872788364023 no 2566 0.223826478117249 3763 5320438 An anti-inflammatory.
SGTC_343 4130-2827 29.8 µM -0.75962623569036 0.246789983875213 no 2567 0.223739016140829 3838 1118244
SGTC_2047 4141938 200 µM -0.760289174450059 0.246602381645433 no 2568 0.223540875671592 3766 3807862
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.761156057581457 0.246357181360109 no 2569 0.223281930544304 3809 688664
SGTC_2918 7977171 22.06 µM -0.761602865048439 0.246230851689596 no 2570 0.223148532176183 3713 2236483
SGTC_753 1322-0200 289 µM -0.761689738836812 0.246206293159402 no 2571 0.22312260049899 3798 5403907
SGTC_342 k048-0088 23.3 µM -0.761952205438085 0.246132103914438 no 2572 0.223044265091048 3768 6820570
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.762299920047709 0.246033836792704 no 2573 0.222940510806723 3721 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2867 9039098 71.43 µM -0.762838233496514 0.245881746333897 no 2574 0.222779938127131 3746 6463460
SGTC_682 0kpi-0099 17 µM -0.766698035451476 0.244792710573395 no 2575 0.221630535980724 3803 1714895 YML126C ERG13
SGTC_1480 1070-0044 41.2 µM -0.769037671531202 0.24413385279145 no 2576 0.220935473648806 3781 3124987
SGTC_1997 st073024 93.8 µM -0.769402981414969 0.244031065370989 no 2577 0.220827059619833 3757 686268
SGTC_2371 9071574 200 µM -0.770726180976742 0.243658951553604 no 2578 0.220434625097753 3747 45596039
SGTC_3316 9136639 10.545 µM -0.770739380899351 0.243655240979162 no 2579 0.220430712279389 3820 4903665
SGTC_1605 st000082 49.1 µM -0.770993207817826 0.243583894701991 no 2580 0.220355478776022 3790 1114022
SGTC_2176 5809774 33.9695 µM -0.771956095006681 0.243313346680304 no 2581 0.220070215895857 3786 2870539
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.772363507637081 0.243198922495351 no 2582 0.219949580517954 3809 23847180
SGTC_405 ebelactone b 50 µM -0.773832620582264 0.242786555356643 no 2583 0.219514889627765 3763 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_766 1391-0721 126 µM -0.77426587793169 0.242665016110522 no 2584 0.219386788855762 3774 1020919 YIL115C NUP159
SGTC_164 4100-3994 89.624 µM -0.775446205717104 0.24233407257488 no 2585 0.21903802050028 3784 4615967
SGTC_365 0121-0052 13.6 µM -0.776250972932055 0.242108570041111 no 2586 0.218800407333688 3830 3101739
SGTC_926 2268-1401 59.4 µM -0.776705272091322 0.241981321861563 no 2587 0.218666337843616 3778 2931578
SGTC_1921 5740136 50 µM -0.776927619509728 0.2419190560708 no 2588 0.218600737516849 3737 1774243
SGTC_289 k017-0060 526 µM -0.77787811129771 0.241652979997789 no 2589 0.218320436701631 3791 5512909
SGTC_2720 fluspirilene 36.88 µM -0.777974237882931 0.241626079635394 no 2590 0.218292100425694 3768 3396 An atypical antipsychotic.
SGTC_339 3091-4833 71.4 µM -0.77889177555305 0.241369394880396 no 2591 0.218021734555519 3726 3240077
SGTC_2329 6138490 200 µM -0.779575428715083 0.241178236587992 no 2592 0.217820411739062 3907 720019
SGTC_6 0844-0013 19.835 µM -0.779741963348416 0.241131683811886 no 2593 0.217771386712152 3900 1584900
SGTC_423 5-fluorouracil 457 µM -0.779803121455747 0.241114589016812 no 2594 0.217753384380384 3778 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_112 phenothiazine 287.218 µM -0.780139235938394 0.241020650713051 no 2595 0.217654461973968 3756 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_63 0099-0242 26.702 µM -0.780558366575413 0.24090353868849 no 2596 0.217531143282473 3852 3898502 YLR359W ADE13
SGTC_1168 k815-0004 80.5 µM -0.782687419033602 0.24030912451827 no 2597 0.216905345977653 3781 642433
SGTC_2502 avocadyne acetate 18.59 µM -0.783623735694559 0.240047965712139 no 2598 0.21663046206967 3774 3952079
SGTC_3096 9117468 49.47 µM -0.78417181608525 0.239895166160759 no 2599 0.216469650134936 3750 41316311
SGTC_428 3448-4153 16.5 µM -0.784856713951519 0.239704297801713 no 2600 0.216268791797625 3789 3834874
SGTC_2906 7926292 26.41 µM -0.78499831107463 0.239664847644367 no 2601 0.21622727941619 3783 2966319
SGTC_178 4092-0806 87.505 µM -0.785336105241849 0.239570749640777 no 2602 0.216128266091902 3767 2169044
SGTC_3231 9132313 49.47 µM -0.78595505572642 0.23939838336547 no 2603 0.215946909131055 3802 4905967
SGTC_3326 9140064 16.379 µM -0.788032747699311 0.238820280123194 no 2604 0.215338775512094 3779 1868434
SGTC_2147 5545932 89.7195 µM -0.788188133760572 0.238777075750625 no 2605 0.21529333449438 3845 797404
SGTC_1642 st009582 77.7 µM -0.788519710870682 0.2386848965738 no 2606 0.215196386867472 3779 6739311
SGTC_3236 9132701 49.47 µM -0.7887333993358 0.238625501023027 no 2607 0.215133921347238 3820 24282524
SGTC_2056 5235370 200 µM -0.788933984902894 0.238569754835221 no 2608 0.215075295651546 3807 5511916
SGTC_1482 3346-2049 8.48 µM -0.789044002883227 0.238539181968753 no 2609 0.215043144333058 3829 3826804
SGTC_741 4582-0002 126 µM -0.7902127940215 0.238214519372448 no 2610 0.214701752728086 3773 2912688
SGTC_2472 5377652 49.4 µM -0.790932462232186 0.238014733013855 no 2611 0.214491701970177 3886 1610903
SGTC_312 4092-0653 6.84 µM -0.791800108740011 0.237773988718023 no 2612 0.214238619466051 3805 1148278
SGTC_1574 spiramycin 23.7 µM -0.792664545946038 0.237534267784448 no 2613 0.213986645923715 3801 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2326 6164455 177.58 µM -0.795183844647683 0.236836387055697 no 2614 0.213253283950817 3830 2888790
SGTC_2686 alizarin 95.37 µM -0.795557933560388 0.236732855450445 no 2615 0.21314451264757 3840 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3065 9113888 49.47 µM -0.796443428571354 0.236487888017756 no 2616 0.21288717224406 3861 16648368
SGTC_275 trichlorophene 5.69 µM -0.798585512223743 0.235895869450385 no 2617 0.212265395537505 3872 62616
SGTC_970 1315-0089 19.5 µM -0.801894867762964 0.234982854126646 no 2618 0.211306887574599 3786 6811083 YLR033W RSC58
SGTC_2738 aclarubicin 5.55 µM -0.803108935824067 0.234648396082072 no 2619 0.210955886660652 3778 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1660 st012960 28.1 µM -0.803702952078435 0.234484849228743 no 2620 0.210784274407565 3835 24207266
SGTC_515 4092-1064 102 µM -0.804416206599376 0.234288556584493 no 2621 0.210578322252608 3844 717353
SGTC_1386 3228-0095 33.8 µM -0.807719203702398 0.233380735531807 no 2622 0.209626123027233 3853 870181
SGTC_2150 5556613 200 µM -0.807917255540965 0.23332636353551 no 2623 0.209569108555392 3844 743190
SGTC_23 0213-0011 39.996 µM -0.80805756778629 0.23328784728459 no 2624 0.20952872147665 3842 627608
SGTC_784 4579-0127 173 µM -0.80860432683982 0.233137793490115 no 2625 0.209371387588936 3949 1948547
SGTC_481 bay k-8644 50 µM -0.808829224637362 0.233076087584987 no 2626 0.209306691799557 3817 2303 A calcium channel antagonist.
SGTC_410 α-linolenic acid 100 µM -0.811105604609477 0.232452020857126 no 2627 0.20865251378051 3933 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_617 3770-0098 35 µM -0.811273229144379 0.232406103563523 no 2628 0.208604390122904 3788 5962639
SGTC_3000 9075062 71.4286 µM -0.814454525215223 0.231535610022643 no 2629 0.207692306712643 3833 17057871
SGTC_1245 0418-0076 17.2 µM -0.814767314809251 0.231450120097732 no 2630 0.207602756748252 3917 6790114
SGTC_2069 5228469 200 µM -0.815027443549031 0.231379036553724 no 2631 0.207528300680412 3841 2835210
SGTC_3079 9117512 49.47 µM -0.816178432984809 0.231064659956141 no 2632 0.207199044996976 3867 7185044
SGTC_1287 0971-0001 34.6 µM -0.816462200103262 0.23098718960301 no 2633 0.207117917177235 3843 4665869
SGTC_72 0744-0168 198.391 µM -0.816872581575056 0.230875178322132 no 2634 0.207000624092885 3772 677577
SGTC_2777 climbazole 1.536 µM -0.819574580557797 0.23013844087454 no 2635 0.20622933474366 3789 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1190 1486-1332 13 µM -0.819747970160066 0.230091208748464 no 2636 0.206179898676516 3848 4150046
SGTC_966 1300-0360 30.2 µM -0.820768515911759 0.229813317322576 no 2637 0.205889067638307 3858 70588
SGTC_1397 3532-0190 20.1 µM -0.82497029301641 0.228671168287322 no 2638 0.204694228269636 3778 5322280
SGTC_1744 st037937 38.9 µM -0.826052882224696 0.228377410486256 no 2639 0.204387047123365 3944 1016152
SGTC_3113 9123498 49.47 µM -0.82922302305339 0.22751842175852 no 2640 0.203489109740878 3923 8897275
SGTC_3170 9103054 49.47 µM -0.830220173615029 0.22724860817131 no 2641 0.203207155649329 3902 16432970
SGTC_2087 5276107 200 µM -0.832044929119532 0.226755324656306 no 2642 0.202691792368409 3850 144405
SGTC_250 brefeldin a 552.239 µM -0.832262672916018 0.226696502666491 no 2643 0.202630347481938 3754 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2706 st078239 82.5 µM -0.832680088360894 0.22658376483304 no 2644 0.202512588599907 3856 15434492
SGTC_1469 k284-2957 126 µM -0.833443733246335 0.226377597403971 no 2645 0.202297259348802 3859 23884841
SGTC_1616 st002734 56.1 µM -0.834926515872054 0.225977581245924 no 2646 0.201879542093088 3843 4026101
SGTC_840 0245-0196 390 µM -0.836746317217084 0.225487192833083 no 2647 0.201367589110147 3985 3827528
SGTC_978 1416-0512 87.4 µM -0.837008900385074 0.22541648336531 no 2648 0.201293782576302 3949 6814003
SGTC_2980 9014342 25.29 µM -0.837696266446937 0.225231446077926 no 2649 0.201100655426763 3958 2996599
SGTC_1071 trifluoperazine 6.31 µM -0.841420110929545 0.224230492966182 no 2650 0.200056311446855 3994 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2741 miltefosine 3.04 µM -0.844684329271209 0.223355166614556 no 2651 0.199143555602801 3845 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1610 st001799 48.1 µM -0.844806268106302 0.223322505455763 no 2652 0.199109507179568 3800 621897
SGTC_10 0279-0212 42.575 µM -0.845365446655597 0.223172765021547 no 2653 0.198953415232102 3868 39851 YBR002C RER2
SGTC_2948 9070189 9.45 µM -0.846288261131893 0.222925772861447 no 2654 0.198695977432276 3804 6473636 YDL196W YDL196W
SGTC_2653 dihydrofissinolide 100 µM -0.848289371852853 0.222390708994272 no 2655 0.198138417546322 3937 6857746
SGTC_134 0269-0018 6.916 µM -0.848797580380864 0.222254939183978 no 2656 0.197996968394713 3866 4378915
SGTC_2456 5770359 74.46 µM -0.848918266739537 0.222222704322159 no 2657 0.197963386848955 3927 3118787
SGTC_123 0083-0120 66.675 µM -0.849428672348734 0.222086406452244 no 2658 0.197821402136242 3884 16001701
SGTC_2751 anetholtrithion 17.25 µM -0.849542489459085 0.222056019427556 no 2659 0.197789748866409 3921 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_826 1683-5028 118 µM -0.850203398548885 0.221879616062514 no 2660 0.197606006288064 3957 722377
SGTC_3318 9139014 38.6185 µM -0.850328659955783 0.221846191541808 no 2661 0.197571193384322 3891 16643984
SGTC_1346 1488-2224 62.4 µM -0.850413214297666 0.221823630844523 no 2662 0.197547695966664 3862 3722427
SGTC_2351 9026858 72.31 µM -0.850444980069545 0.221815155474574 no 2663 0.197538868783147 3834 1409300
SGTC_1750 st081859 2.357 µM -0.853119039459019 0.221102357833518 no 2664 0.19679664703065 3883 5291695
SGTC_2734 clemastine 41.6 µM -0.854612467392398 0.220704840553655 no 2665 0.196382861638835 3920 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_591 4299-0174 154 µM -0.856509219173701 0.220200558033466 no 2666 0.195858087813075 3892 5509088
SGTC_1038 k292-0204 154 µM -0.857493160758521 0.219939221558646 no 2667 0.195586196482492 3862 4454212
SGTC_517 1365-0151 113 µM -0.857658167679264 0.219895412886542 no 2668 0.195540622778949 3993 768657
SGTC_2 0422-0095 29 µM -0.857785191298462 0.219861692039458 no 2669 0.195505544178386 3777 6790840
SGTC_3125 9127534 49.47 µM -0.858902248155226 0.219565275790376 no 2670 0.195197224493819 3778 1639235
SGTC_2595 hexamethylquercetagetin 100 µM -0.861464942734772 0.218886120816561 no 2671 0.194491010682361 3899 386331
SGTC_1670 st016595 4.04 µM -0.862293052371191 0.21866691718102 no 2672 0.194263137487126 3922 597879
SGTC_3284 9108171 64.8615 µM -0.862427116708984 0.218631441750585 no 2673 0.194226261933563 3906 8687505
SGTC_1915 st067105 30.6 µM -0.863036849424764 0.218470139153214 no 2674 0.194058603476597 3887 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2258 7960471 200 µM -0.863745182677145 0.218282838220272 no 2675 0.193863943540916 3958 2974708
SGTC_2295 7971645 200 µM -0.863785882752379 0.218272078919296 no 2676 0.193852762204913 3984 2978226 YKL099C UTP11
SGTC_914 3820-6779 408 µM -0.865446031773483 0.217833469389585 no 2677 0.193397012525514 3878 2893481
SGTC_1864 st057645 30.4 µM -0.865797435498521 0.217740694146736 no 2678 0.193300627895531 3962 688666
SGTC_400 oxethazaine 37.5 µM -0.866441554452276 0.21757069740069 no 2679 0.19312403211545 3944 4621 A local anesthetic.
SGTC_2094 5332512 191.667 µM -0.867246296479562 0.217358416465419 no 2680 0.192903537334027 3975 755774
SGTC_2839 9003951 25.97 µM -0.867301190663336 0.217343940421279 no 2681 0.192888502241142 3971 2990634
SGTC_1811 st050069 61.5 µM -0.868960388899899 0.216906659095732 no 2682 0.192434398498888 3868 3877702
SGTC_2929 9013348 24.6 µM -0.870142693853463 0.216595373441297 no 2683 0.192111214223149 3960 2995952
SGTC_2033 5192550 145 µM -0.87025234034905 0.216566518032849 no 2684 0.192081259077384 3913 182073
SGTC_831 k061-1017 217 µM -0.870398581318138 0.216528035604958 no 2685 0.192041310862116 3982 1240153
SGTC_1178 0988-0033 191 µM -0.870866672805742 0.216404886759035 no 2686 0.191913477872662 3993 5392207
SGTC_1362 1611-0397 101 µM -0.871264802037694 0.216300175990347 no 2687 0.191804792158425 3891 27816
SGTC_1570 verbenone 133 µM -0.871726852490612 0.216178690274188 no 2688 0.19167870378131 3969 29025 A natural terpanoid with antifungal properties.
SGTC_985 1493-0307 8.71 µM -0.872004368719612 0.216105742654941 no 2689 0.191602997127104 3965 3278274
SGTC_1955 wogonin 32.4 µM -0.873419820979142 0.21573390025143 no 2690 0.191217145610403 4026 5281703 A flavanone.
SGTC_1767 st044992 70.3 µM -0.87377971696469 0.215639413963389 no 2691 0.191119114169965 3983 9600693
SGTC_1425 4048-4433 7.33 µM -0.874567015765066 0.215432801972985 no 2692 0.190904770691057 3977 23734946
SGTC_2201 6605497 169.863 µM -0.874794206831483 0.215373201242798 no 2693 0.190842944953313 3870 670741
SGTC_117 lucigenin 22.078 µM -0.875198938019353 0.215267048790786 no 2694 0.190732835480598 3977 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_450 aminopyrene 156 nM -0.877259996459017 0.214726947862785 no 2695 0.190172717567003 3845 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2251 lansoprazole 556 µM -0.877756192491876 0.214597037259554 no 2696 0.190038021307669 3852 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2236 dapsone 200 µM -0.877813099789179 0.214582141106498 no 2697 0.19002257712965 3941 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1129 3453-1384 223 µM -0.878773489682368 0.21433083845847 no 2698 0.189762051499937 4080 1084452
SGTC_3240 9133527 49.47 µM -0.881210497003922 0.213693922116121 no 2699 0.189101949403424 3892 17617455
SGTC_1508 1080-0625 72.9 µM -0.882619732625742 0.213326119458496 no 2700 0.18872088170796 3829 767111
SGTC_542 3381-0244 89.3 µM -0.88538813348771 0.212604657900389 no 2701 0.18797366515013 3990 1112843
SGTC_38 0929-0051 58.268 µM -0.886404494078895 0.212340146374391 no 2702 0.187699799188407 3971 1379719
SGTC_93 0109-0045 59.227 µM -0.886793585822714 0.212238934764925 no 2703 0.187595020782754 4028 88733
SGTC_193 1273-0060 1.558 µM -0.886932652557617 0.21220276718672 no 2704 0.187557580309357 3774 2847393 YHR072W ERG7
SGTC_3341 9147222 25.867 µM -0.88821010051107 0.211870705365881 no 2705 0.187213873306536 3964 1939759
SGTC_269 exalamide 29 µM -0.889458376569097 0.21154652038303 no 2706 0.186878391735125 3879 3316 A derivative of salicylamide.
SGTC_136 0097-0015 404.482 µM -0.889967698860383 0.211414329713719 no 2707 0.186741615287865 3951 4861337
SGTC_2815 7968870 71.43 µM -0.890462369139362 0.211285988182641 no 2708 0.186608832914327 3948 2977326 YHR190W ERG9
SGTC_2074 5212007 75.395 µM -0.89153736848004 0.211007238490646 no 2709 0.186320476749067 3797 758611
SGTC_334 1502-1024 68.5 µM -0.892909506970541 0.210651753352036 no 2710 0.185952817754572 4005 3296216
SGTC_1492 4158-0558 28.5 µM -0.892915703977422 0.210650148667339 no 2711 0.18595115831254 3955 3967268
SGTC_2571 chrysanthemic acid 100 µM -0.895479225906986 0.209986952509234 no 2712 0.185265483004014 3986 2743 An insecticide.
SGTC_2891 9063876 19.48 µM -0.898532123938492 0.209198755069424 no 2713 0.184450963484131 3962 6472478
SGTC_1742 st038235 28.8875 µM -0.898626439791777 0.209174432363109 no 2714 0.184425835342596 4020 564103 YBR002C RER2
SGTC_2104 5389443 200 µM -0.898890977884034 0.20910622066623 no 2715 0.184355367031914 4034 2244536
SGTC_2379 9035213 200 µM -0.899886454465823 0.208849652369213 no 2716 0.184090339682321 3928 646551
SGTC_2296 7971656 126.45 µM -0.900346322017567 0.20873119146234 no 2717 0.183967988527812 4020 666570
SGTC_2979 9012552 45.46 µM -0.901955262081828 0.208317043667833 no 2718 0.183540316775488 4000 17100905
SGTC_934 2950-0684 338 µM -0.902858801360768 0.208084681638772 no 2719 0.183300419258807 4041 1121253
SGTC_2614 arthonioic acid 13.39 µM -0.903794246392002 0.207844275699302 no 2720 0.183052256593164 3877 6710684
SGTC_2673 kobusone 100 µM -0.905213744691906 0.207479783316797 no 2721 0.182676080829473 4025 6710676 An epoxy ketone and protein crosslinker.
SGTC_502 l-744,832 89.3 µM -0.90555100649886 0.207393238326736 no 2722 0.182586775394598 3981 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.905675672601603 0.207361253073389 no 2723 0.182553771265045 4008 279621
SGTC_2186 6124449 200 µM -0.905753746898625 0.207341223242078 no 2724 0.182533103757189 3976 3834182 YLR033W RSC58
SGTC_1450 4112-4260 37.6 µM -0.906380363406679 0.207180507255086 no 2725 0.182367281341079 3947 1633175
SGTC_280 3448-3607 3.04 µM -0.907477189705603 0.206899368252634 no 2726 0.182077253285739 3960 626179
SGTC_271 rotenone 740 µM -0.907547773310353 0.20688128396783 no 2727 0.18205859911217 4005 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1694 st024011 44.9 µM -0.911046754615077 0.205985980275795 no 2728 0.181135369684799 4003 2787533
SGTC_1883 5-benzylidenerhodanine 20 µM -0.911070209143423 0.205979986600077 no 2729 0.181129190963931 3984 1273210
SGTC_2784 7567673 72.73 µM -0.913070384329362 0.205469233466934 no 2730 0.180602762540543 3957 3471247
SGTC_1347 1493-0251 600 nM -0.914705659565803 0.205052218369794 no 2731 0.180173086212573 4046 3986378
SGTC_1960 st011366 51.8 µM -0.914932153964328 0.204994499229938 no 2732 0.1801136243665 4001 3972846
SGTC_2792 7535235 81.82 µM -0.91519562944316 0.204927368098456 no 2733 0.180044469335692 3991 1281891
SGTC_768 0384-0033 77.3 µM -0.915794991378134 0.204774704877661 no 2734 0.179887215501143 3980 3965305 YMR134W ERG29
SGTC_2885 9057732 51.95 µM -0.918095408658091 0.204189394910959 no 2735 0.179284459186556 4061 6471414
SGTC_2443 5493264 126.67 µM -0.918568280568837 0.204069202641785 no 2736 0.179160714640658 4024 5340055
SGTC_3249 9135183 49.47 µM -0.918818847939576 0.204005531740014 no 2737 0.179095166138254 4007 4902779
SGTC_2587 piperic acid 92.2 µM -0.919311866142845 0.203880286966217 no 2738 0.178966236476647 3999 5370536
SGTC_524 r073-0010 27.8 µM -0.920845973953398 0.203490860359522 no 2739 0.178565424230999 3918 2772106
SGTC_689 0833-0039 98 µM -0.920979276537525 0.203457043042352 no 2740 0.178530623337983 3965 5374726
SGTC_779 1360-0071 233 µM -0.923812035760726 0.202739197841881 no 2741 0.177792093835889 4071 7566
SGTC_1920 st075728 45.7 µM -0.926513533690455 0.202056027160284 no 2742 0.177089583565546 3937 3400306
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.926579115751651 0.202039459529789 no 2743 0.177072551127913 4002 688662
SGTC_3138 9097216 49.47 µM -0.927323458751223 0.201851477292522 no 2744 0.176879308977349 3976 25237486
SGTC_1704 st028805 70.8 µM -0.929920139710232 0.201196511405931 no 2745 0.176206217288472 4043 2876101
SGTC_2914 7968218 45.32 µM -0.931114592807271 0.20089566058173 no 2746 0.175897145407425 3972 2977111
SGTC_1924 st058459 75.1 µM -0.931617570986081 0.200769054623979 no 2747 0.175767099585693 3974 688683
SGTC_487 nimodipine 119 µM -0.931929067345219 0.200690671075648 no 2748 0.175686592245957 3938 4497 L-type voltage-gated calcium channels inhibitor
SGTC_544 k015-0020 52.4 µM -0.932067069741273 0.200655950644 no 2749 0.1756509325062 4011 3008304
SGTC_1664 st014217 9.02 µM -0.932344551675903 0.200586149058239 no 2750 0.175579245216576 4048 3982782
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.933513336842432 0.200292296996156 no 2751 0.175277493840268 4022 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1510 1123-0200 71.5 µM -0.933622335639231 0.200264906074596 no 2752 0.175249369824698 4082 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_935 2996-0153 430 µM -0.934395451609128 0.200070690016336 no 2753 0.175049971547013 4036 23738523
SGTC_2833 9001315 45.46 µM -0.935853103605421 0.199704818378698 no 2754 0.174674412785827 3993 2989378
SGTC_2475 5812728 15.03 µM -0.937275894777853 0.199348085328585 no 2755 0.174308329537658 3974 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3224 9130643 49.47 µM -0.939271222888071 0.198848448305284 no 2756 0.17379575476747 4059 17644395
SGTC_1441 4106-0040 13 µM -0.94041153799653 0.198563248757428 no 2757 0.17350325307163 4006 2904180
SGTC_1383 3049-0032 20.7 µM -0.940630187167137 0.198508591511404 no 2758 0.173447203292737 4090 712864
SGTC_2818 7996756 12.99 µM -0.942168662993522 0.198124264731228 no 2759 0.17305314750245 4023 2241621
SGTC_948 3448-0295 75.3 µM -0.946740918999648 0.196984723490838 no 2760 0.171885407002171 4008 678569
SGTC_574 1315-0397 40 µM -0.948164571526439 0.196630718801353 no 2761 0.171522840048866 4014 6794277
SGTC_2531 methyl deoxycholate 70.07 µM -0.948842633841772 0.196462247759771 no 2762 0.171350327304011 3988 16667744 Haematoxylin.
SGTC_1339 1486-1321 22.7 µM -0.950869979726307 0.195959056367103 no 2763 0.170835191419736 4040 3469382
SGTC_1805 st050013 60.3 µM -0.952989781956626 0.195433754177979 no 2764 0.170297623950686 3960 4037144
SGTC_1317 1273-0028 910 nM -0.954121533105821 0.195153648691876 no 2765 0.170011063741679 4012 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_265 mycophenolic acid 32.932 µM -0.954870921834239 0.194968311258909 no 2766 0.169821488161306 4123 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_411 enrofloxacin 100 µM -0.956054401487878 0.194675833317181 no 2767 0.169522375214697 4131 71188 A bacterial gyrase inhibitor.
SGTC_2192 5915882 198.485 µM -0.957417887275041 0.194339200893662 no 2768 0.169178186803744 3990 2876149
SGTC_2364 9055074 200 µM -0.959359648477028 0.193860409670581 no 2769 0.168688797832695 4074 6470630
SGTC_639 0833-0042 114 µM -0.960756029449934 0.193516540818413 no 2770 0.168337425976275 4046 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2473 5854593 8.94 µM -0.962801003780886 0.193013623096885 no 2771 0.167823698454039 3946 2872951
SGTC_2930 9013230 14.89 µM -0.963891991750602 0.19274564470572 no 2772 0.16755003962398 4067 2995857
SGTC_1020 4335-0961 93.3 µM -0.965342318311356 0.192389754473913 no 2773 0.167186691150003 3977 669075
SGTC_211 3455-0679 143.504 µM -0.965699505852022 0.19230216725847 no 2774 0.167097283422268 4094 748649
SGTC_2691 st077356 60.2 µM -0.968306280783138 0.191663689505727 no 2775 0.166445714469269 4114 2839272
SGTC_2581 avocatin a 64 µM -0.969283928332073 0.191424569306423 no 2776 0.166201772903341 4036 6710728 A skin care supplement.
SGTC_2998 9066762 71.4286 µM -0.969317867286089 0.191416271552956 no 2777 0.166193308641654 4096 4945196
SGTC_3092 9117248 49.47 µM -0.969779516704399 0.191303424524241 no 2778 0.16607820247378 4134 17141857
SGTC_3167 9103034 49.47 µM -0.973433363494751 0.190411706048178 no 2779 0.16516898191361 4105 5127859
SGTC_3334 9142812 21.919 µM -0.973875876637734 0.190303884619979 no 2780 0.165059086407215 4059 45283678
SGTC_68 0986-0284 82.829 µM -0.974209103549517 0.190222716307096 no 2781 0.164976362738979 4135 423278 YIL048W NEO1
SGTC_945 3381-0768 11.3 µM -0.974214806048074 0.190221327462199 no 2782 0.164974947325893 4104 1126236 YIL048W NEO1
SGTC_1600 coumarin 106 71.1 µM -0.981199677192145 0.188524840201523 no 2783 0.163247141668919 4133 100336 A hepatotoxic, DNA x-linker.
SGTC_990 3985-0011 41.3 µM -0.982179596195207 0.1882875857138 no 2784 0.163005688843952 4065 5399565 YGL099W LSG1
SGTC_3210 9128157 49.47 µM -0.982193871228827 0.188284130855511 no 2785 0.163002173180741 4114 17590849
SGTC_561 1550-0330 72.9 µM -0.982624867253338 0.188179839172448 no 2786 0.1628960504514 4011 6812934
SGTC_2769 toremifene 3.73 µM -0.982746281328143 0.188150466038525 no 2787 0.162866163176321 4100 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2103 5378138 10 µM -0.982843736328361 0.188126891257572 no 2788 0.162842176244195 4133 244142
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.98457340505614 0.187708780360907 no 2789 0.162416829217533 4107 4174840
SGTC_435 c-PAF 6.7 µM -0.986028972031479 0.187357372922701 no 2790 0.162059448008096 4070 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1000 4048-0884 8.67 µM -0.987274203116981 0.187057068424948 no 2791 0.161754116777292 4123 13040088
SGTC_382 3229-0966 23.2 µM -0.987843940602164 0.186919767779896 no 2792 0.161614541970255 4105 5722370
SGTC_1349 flufenamic acid 69 µM -0.99339036286535 0.185586399788716 no 2793 0.160259878103387 4000 3371 A non-steroidal anti-inflammatory.
SGTC_120 rhodamine 6G 52.259 µM -0.994770189187151 0.1852556065782 no 2794 0.159924024088942 4102 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_522 1273-0010 11.6 µM -0.995204826964719 0.185151484394534 no 2795 0.159818327313569 4184 5705015
SGTC_374 0880-0231 82.3 µM -0.995452047103391 0.18509227635529 no 2796 0.15975822782647 3998 6833587
SGTC_2086 5274770 176.623 µM -0.996491776468094 0.184843394923583 no 2797 0.159505630361549 4111 689278
SGTC_341 1486-1430 230 µM -0.997845861375446 0.18451957777487 no 2798 0.159177053824696 4062 2054753 YPL210C SRP72
SGTC_1667 st014849 34.6 µM -0.998402157745149 0.184386646844643 no 2799 0.159042193867112 4132 5348460
SGTC_2740 felodipine 17.08 µM -0.998827698472975 0.184285001123989 no 2800 0.158939082850347 4097 3333 L-type calcium channel blocker
SGTC_1937 st074714 47.2 µM -1.00317340293876 0.183248972406446 no 2801 0.157888601702553 4054 17250970
SGTC_2091 4-phenylthiadiazole 200 µM -1.00469622635999 0.182886787933316 no 2802 0.157521572903582 4080 270010
SGTC_2171 5739187 198.077 µM -1.00850300139127 0.181983350254683 no 2803 0.156606523785626 4037 2262761
SGTC_697 0508-1955 564 µM -1.00866621939926 0.181944677257264 no 2804 0.156567368838095 4098 6243113
SGTC_747 3448-8087 38.7 µM -1.0087474289102 0.181925437329587 no 2805 0.156547889601498 4136 5168703
SGTC_137 0438-0332 85.389 µM -1.00906798385585 0.18184950478248 no 2806 0.156471015596276 4061 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1804 st050076 49.1 µM -1.00941553815377 0.181767199073297 no 2807 0.156387694822212 4130 3895976
SGTC_3012 9080433 71.4286 µM -1.01304978292528 0.180907955582681 no 2808 0.155518191343163 4097 17688859
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.01715814350228 0.179939687939962 no 2809 0.154539102094295 4095 2724 A muscle relaxant with antifungal properties.
SGTC_1098 clofazimine 15.1 µM -1.01889113246307 0.179532230999912 no 2810 0.154127327001397 4166 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2129 girgensonine 121.053 µM -1.01967881992671 0.179347223328601 no 2811 0.153940404906002 4135 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1398 3558-0053 112 µM -1.02404774895951 0.178323251073686 no 2812 0.152906361118995 4027 4532369
SGTC_838 0109-0203 71.4 µM -1.02632446062671 0.177791107432345 no 2813 0.152369335590348 4112 759422
SGTC_2544 sphondin 68.51 µM -1.02673451673015 0.17769537017758 no 2814 0.152272745702063 4116 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_345 1362-0200 395 µM -1.02707506087584 0.177615886854827 no 2815 0.152192560457799 4108 1419823
SGTC_1149 3909-7961 23.3 µM -1.02818048958972 0.177358033404235 no 2816 0.151932467118862 4157 735261
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.02823912717351 0.177344362144937 no 2817 0.151918678691902 4213 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_475 α-linolenic acid 10 µM -1.02892635644285 0.177184185335003 no 2818 0.151757141048513 4142 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2747 doxorubicin 7.63 µM -1.02942703193052 0.177067547332771 no 2819 0.151639525964164 4091 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3208 9114115 49.47 µM -1.02996616214632 0.176942005120924 no 2820 0.151512945136749 4134 650895
SGTC_1417 3966-0327 90.4 µM -1.03459122144187 0.175867322920857 no 2821 0.150429927700286 4217 651118
SGTC_344 k064-0035 6.43 µM -1.03611367614158 0.175514470495113 no 2822 0.150074556324231 4081 5088750
SGTC_2647 atorvastatin 60.16 µM -1.03698683899314 0.175312304107459 no 2823 0.149870995402082 4095 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_407 eburnamonine 100 µM -1.03839981141656 0.174985466691954 no 2824 0.149541978665429 3968 3195
SGTC_249 wiskostatin 11.211 µM -1.03936008571958 0.174763564570242 no 2825 0.149318649966591 4064 2775510 A n-wasp and actin depolymerizer.
SGTC_1001 4048-4355 44.4 µM -1.04042080026366 0.174518660243115 no 2826 0.14907222107932 4111 21824233
SGTC_49 0717-0965 32.132 µM -1.0407194578931 0.174449743669038 no 2827 0.149002884941773 4222 5889349 YGL099W LSG1
SGTC_1130 3454-2858 15.9 µM -1.04185175418576 0.174188618308452 no 2828 0.148740207563187 4168 715628 YIL048W NEO1
SGTC_2105 5350118 200 µM -1.04483355767819 0.173502156620455 no 2829 0.148049951147151 4109 2133313
SGTC_420 mitomycin C 81.9 mM -1.04571854754521 0.173298748744776 no 2830 0.147845498447334 4122 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3118 9124250 49.47 µM -1.04626657587253 0.173172864951005 no 2831 0.147718986313121 4066 1504786
SGTC_769 0302-0231 76 µM -1.04688915933762 0.173029926290481 no 2832 0.147575351141885 4068 571869 YER009W NTF2
SGTC_1583 clindamycin 39.6 µM -1.0497425857827 0.172375771400494 no 2833 0.146918239304324 4124 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2333 9017922 200 µM -1.04980838790547 0.172360704738844 no 2834 0.146903109005482 4180 3163164
SGTC_2151 5563267 85.4165 µM -1.05061174092963 0.172176829352627 no 2835 0.146718473225296 4187 5310824
SGTC_42 0133-0086 60.653 µM -1.05146395314921 0.171981907721064 no 2836 0.146522778333504 4023 162923 Model of phenazepam hydroxylation.
SGTC_2844 9010103 25.97 µM -1.05150279437066 0.171973027148488 no 2837 0.146513863336498 4166 2480525
SGTC_894 0960-0238 55.9 µM -1.05577682755988 0.170997610314725 no 2838 0.145535093684042 4151 6741907 YDL195W SEC31
SGTC_1419 3993-2473 62.6 µM -1.05614807362251 0.170913052181108 no 2839 0.145450284977987 4215 704026
SGTC_2261 9010538 184.68 µM -1.05647037701983 0.170839663340654 no 2840 0.145376683860625 4159 6457250
SGTC_650 1328-0195 38 µM -1.0570381246805 0.170710435624807 no 2841 0.145247094102284 4138 2780821
SGTC_183 3914-0051 30.55 µM -1.05774153262583 0.170550416437662 no 2842 0.145086647392698 4181 1596232
SGTC_1795 st049545 62.3 µM -1.05807583141964 0.170474400050301 no 2843 0.145010435977066 4099 5291882
SGTC_3265 9137266 49.47 µM -1.05929695210191 0.170196913156518 no 2844 0.144732281301926 4081 17224265
SGTC_836 0330-0104 1.35 µM -1.05947148492693 0.170157276050459 no 2845 0.144692554469519 4169 46494820
SGTC_1663 st014140 55.4 µM -1.06125886742462 0.16975169482172 no 2846 0.14428613659951 4223 4207120
SGTC_1827 berberine 7.24 µM -1.06426229669665 0.169071573590551 no 2847 0.143604946446341 4082 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1974 st069448 26.9 µM -1.06524440730463 0.168849556591856 no 2848 0.143382671400709 4143 6323587 YNR016C ACC1
SGTC_1345 1488-0192 31.4 µM -1.06665882121507 0.168530141934687 no 2849 0.143062964198804 4211 658348
SGTC_2779 methotrexate 400 µM -1.06685592856821 0.168485660380856 no 2850 0.14301844928215 4185 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3081 9117243 49.47 µM -1.06773377426638 0.168287647123453 no 2851 0.142820309419744 4142 45595589
SGTC_2655 perillic acid 100 µM -1.07002293174705 0.167771992563038 no 2852 0.14230449340175 4177 5702197 An apoptosis inducer.
SGTC_2385 9074692 200 µM -1.07167708314315 0.167400013059074 no 2853 0.141932548764349 4176 17046906
SGTC_263 alizarin 107.927 µM -1.07190001904269 0.167349920721029 no 2854 0.141882470833847 4193 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1380 2291-0730 164 µM -1.07305928244872 0.167089597035189 no 2855 0.141622259203661 4189 2999191
SGTC_2819 7996655 46.38 µM -1.07353911332294 0.166981922867737 no 2856 0.141514649634057 4114 6456960
SGTC_1688 st021091 57.6 µM -1.07577079092874 0.1664817220688 no 2857 0.141014889257285 4190 3656366
SGTC_1715 st032160 10.2275 µM -1.07701987723247 0.166202178677908 no 2858 0.140735692815777 4105 5289825
SGTC_2168 5727979 200 µM -1.07873850075964 0.165818049527044 no 2859 0.140352158656913 4068 695210
SGTC_2684 capsaicin 100 µM -1.07916910327078 0.16572189563993 no 2860 0.140256175163675 4184 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_885 0865-0106 16.8 µM -1.08104160578411 0.165304183657792 no 2861 0.139839303355401 4103 2793380
SGTC_2318 6029776 164 µM -1.08585463384768 0.164233637644222 no 2862 0.138771655309138 4246 818325
SGTC_1434 4073-0095 163 µM -1.08660207946947 0.164067789989932 no 2863 0.13860635282952 4129 24133745
SGTC_3165 9101544 49.47 µM -1.0910575140628 0.163081446670272 no 2864 0.137623787982064 4192 5002184
SGTC_764 1951-2361 146 µM -1.09497876887463 0.162216555398725 no 2865 0.136762968992648 4192 5438930
SGTC_809 3998-0021 90 µM -1.09541453267124 0.162120625908706 no 2866 0.136667535083024 4146 715485
SGTC_2360 9040895 200 µM -1.09984560032449 0.161147264376844 no 2867 0.135699700108243 4215 4914414
SGTC_452 diindolylmethane 8 µM -1.10099648860289 0.16089507672106 no 2868 0.135449092706005 4192 3071 Inhibits expression of several cancer promoting factors.
SGTC_661 1304-0007 33.6 µM -1.10246027648249 0.160574697564955 no 2869 0.135130809502193 4193 3117130
SGTC_1176 0848-0131 83.3 µM -1.10287640650113 0.160483695338492 no 2870 0.135040420691076 4230 6769040
SGTC_62 0180-0423 3.232 µM -1.1034121199728 0.16036659138455 no 2871 0.134924117873388 4158 30102 YGL099W LSG1
SGTC_659 k018-0002 107 µM -1.10489339049733 0.160043084706707 no 2872 0.134602893360934 4195 6797879 YHR007C ERG11
SGTC_2415 st077333 57.7 µM -1.11231897808869 0.158427786574297 no 2873 0.13300051343876 4264 2766255
SGTC_1237 0330-0133 46.1 µM -1.12114661323752 0.156521461445943 no 2874 0.131112729995822 4156 X1237 YHR072W ERG7
SGTC_3024 9090631 49.47 µM -1.12214730244613 0.156306319969813 no 2875 0.130899907220476 4183 25236383
SGTC_2526 patulin 37.61 µM -1.12239854657182 0.156252334772552 no 2876 0.130846511089607 4239 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2268 7933382 153.85 µM -1.12316191416028 0.156088384213191 no 2877 0.13068436731603 4243 935025 YOR257W CDC31
SGTC_1148 3909-7663 27.7 µM -1.12549355302637 0.155588313890177 no 2878 0.130189973807693 4264 4084526
SGTC_2029 5175081 200 µM -1.12891315500601 0.154856819929053 no 2879 0.129467235400402 4187 1380876
SGTC_2226 7298446 200 µM -1.12951804928287 0.154727662622579 no 2880 0.129339679943428 4216 3283010
SGTC_2971 9092186 9.93 µM -1.13201825265923 0.154194573312597 no 2881 0.128813380364745 4226 25236400
SGTC_1736 st036774 51 µM -1.13327390187573 0.153927304609661 no 2882 0.128549623967619 4270 1272247
SGTC_2117 5521686 200 µM -1.13699895207766 0.153136221257746 no 2883 0.127769361868741 4189 803312
SGTC_3149 9097855 49.47 µM -1.13836489866268 0.152846813612102 no 2884 0.127484072400123 4234 25236625 YMR079W SEC14
SGTC_501 nsc-95397 161 µM -1.14159361341952 0.152164177841184 no 2885 0.126811489971951 4268 262093
SGTC_469 w7 172 µM -1.14323831337737 0.151817224184929 no 2886 0.126469829444402 4312 45115570 A P450 inhibitor.
SGTC_2654 protoveratrine a 100 µM -1.14324170480631 0.151816509297835 no 2887 0.126469125591609 4227 5702278 A heart drug and vasodilator.
SGTC_794 k038-0031 316 µM -1.14535879602764 0.1513706792759 no 2888 0.12603027967987 4225 6624242
SGTC_3276 9139060 49.47 µM -1.14588411245003 0.151260189891027 no 2889 0.125921552913722 4338 4870619
SGTC_694 1315-0438 43.2 µM -1.14605106444117 0.151225086248198 no 2890 0.125887011917904 4240 6793154
SGTC_1684 st024538 14.6195 µM -1.1479143016833 0.150833686194268 no 2891 0.125501971780655 4191 6732859
SGTC_1061 3448-9325 110 µM -1.14795490152517 0.150825165121809 no 2892 0.125493590935912 4178 723482
SGTC_710 3448-4187 58 µM -1.15000983752434 0.150394294876109 no 2893 0.125069909745553 4215 3946412
SGTC_657 3534-0529 86.7 µM -1.1500421922979 0.150387517429172 no 2894 0.12506324692355 4286 1049549
SGTC_2355 9061122 103.12 µM -1.15026765728195 0.150340294284279 no 2895 0.125016823778179 4252 5302957
SGTC_1861 st057647 17.4 µM -1.15264229201081 0.149843532359686 no 2896 0.124528618401924 4331 688668
SGTC_191 3914-0123 66.505 µM -1.15333577581025 0.149698665735589 no 2897 0.124386295633377 4249 3144412
SGTC_1606 st000094 49.2 µM -1.15360991133693 0.149641425448178 no 2898 0.124330066541365 4273 1242210
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.15373523637404 0.149615262084413 no 2899 0.12430436651745 4241 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_599 1935-0052 86.5 µM -1.15772862953468 0.148783183273729 no 2900 0.123487398372259 4237 9557311
SGTC_114 0364-0001 490.298 µM -1.1588999452645 0.148539711145112 no 2901 0.12324848561725 4284 4003655
SGTC_2003 4023581 200 µM -1.16119108844433 0.148064239934783 no 2902 0.122782099010228 4280 16641307
SGTC_2628 lathosterol 100 µM -1.16307666082841 0.147673700004926 no 2903 0.122399200237507 4322 6710616
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.16353249798835 0.147579390616791 no 2904 0.122306760371307 4231 2724278 An inhibitor of dopamine biosynthesis.
SGTC_683 panaxydol 45 µM -1.16425885604102 0.147429195808913 no 2905 0.122159562465426 4246 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2310 7668677 200 µM -1.16813391386357 0.146629650593372 no 2906 0.121376376202387 4266 2197143
SGTC_1457 k015-0032 57.3 µM -1.17185183270417 0.145865268234962 no 2907 0.120628274184105 4243 4302660
SGTC_1161 k007-0610 110 µM -1.17281814380371 0.145667039576107 no 2908 0.120434370288934 4235 5843850
SGTC_2807 7945238 51.95 µM -1.17572918419385 0.145070965006017 no 2909 0.119851556286448 4277 17148797
SGTC_3156 9099931 49.47 µM -1.17752284640783 0.144704507150956 no 2910 0.119493442109076 4298 18111053
SGTC_3337 9144342 33.5465 µM -1.17765241078336 0.144678060400753 no 2911 0.119467603159643 4253 17682949
SGTC_3319 9138450 16.7555 µM -1.17778600723415 0.144650794030622 no 2912 0.119440964223928 4204 2029690
SGTC_2269 7935389 174.42 µM -1.17938038812563 0.144325655991728 no 2913 0.11912337045335 4236 97605
SGTC_1710 st031758 61.5 µM -1.18005244388323 0.144188753061212 no 2914 0.118989678623686 4306 5394341
SGTC_18 0111-0177 500 nM -1.18229363772518 0.143732837606104 no 2915 0.118544604587682 4347 721752
SGTC_1337 1486-1011 40.3 µM -1.18261711256789 0.143667115068071 no 2916 0.118480463672903 4237 X1337
SGTC_336 4111-0029 111 µM -1.18632389167921 0.14291543187467 no 2917 0.117747207499715 4280 3131175
SGTC_2178 5812956 200 µM -1.18774530016166 0.142627896299081 no 2918 0.11746688534809 4246 5403383
SGTC_203 k066-0004 30.888 µM -1.19536649208657 0.141092885530319 no 2919 0.115971935688102 4353 6795412
SGTC_2052 5265182 7.135 µM -1.1977030464195 0.140624524164158 no 2920 0.115516321463017 4292 1239884
SGTC_2449 5812982 45.77 µM -1.1989180192187 0.140381400840168 no 2921 0.115279912217334 4212 776185
SGTC_153 4077-0274 519.67 µM -1.20174268475966 0.139817272038792 no 2922 0.114731618907668 4337 3121976
SGTC_1674 st016616 23.6 µM -1.20174699093951 0.139816413207045 no 2923 0.11473078445787 4231 625830
SGTC_2034 5197015 53.07 µM -1.20427369451325 0.139313101484107 no 2924 0.114241905249999 4298 780676
SGTC_695 3505-6186 243 µM -1.20520952760974 0.139126999585358 no 2925 0.114061212612321 4281 1819379
SGTC_3298 9116858 71.43 µM -1.20640993541696 0.138888531585615 no 2926 0.113829733519621 4357 2506942
SGTC_2646 retinol 96.75 µM -1.21254367830412 0.137674373646293 no 2927 0.112652166728677 4309 445354 A vitamin A analog and teratogen.
SGTC_356 1634-0012 32.5 µM -1.21333337180889 0.137518583890906 no 2928 0.11250119441788 4295 735457
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.21458554490739 0.137271803522867 no 2929 0.112262102394194 4321 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1530 rhein 70.4 µM -1.21514805909154 0.137161040803178 no 2930 0.112154813284576 4352 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_930 2810-3379 265 µM -1.21549713080259 0.13709233700844 no 2931 0.112088271217105 4320 1015764
SGTC_1323 1348-1351 11.2 µM -1.21578495558597 0.137035705434927 no 2932 0.112033425626169 4286 6989654
SGTC_1941 st076221 61.8 µM -1.21591849545514 0.137009435945092 no 2933 0.112007985852631 4176 2828568
SGTC_1289 0976-0073 69.1 µM -1.21707271992265 0.136782524404022 no 2934 0.111788274499777 4367 3391136
SGTC_1790 st045711 43.5 µM -1.21969577260216 0.136267808403477 no 2935 0.111290112371285 4302 585119
SGTC_1516 st013856 110 µM -1.22076688931916 0.136058007048328 no 2936 0.111087146816535 4349 5281404 A mutagen and neurotoxin.
SGTC_3168 9103419 49.47 µM -1.22149400322592 0.1359157121362 no 2937 0.110949517378749 4331 16649256
SGTC_2127 5253358 187.912 µM -1.22435118656134 0.135357553468237 no 2938 0.110409887567593 4209 20612
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.22454749025591 0.135319262760536 no 2939 0.110372881336789 4341 4620898
SGTC_700 3453-2283 142 µM -1.22509201841663 0.135213086770434 no 2940 0.110270276054346 4354 565664
SGTC_2345 9052315 157.45 µM -1.2253050129078 0.135171571127402 no 2941 0.110230160182258 4325 6469265
SGTC_835 0312-0010 67.2 µM -1.2281995747859 0.134608246409706 no 2942 0.109686029148382 4316 1626196
SGTC_2382 9035899 200 µM -1.22898542545011 0.134455586717129 no 2943 0.10953863526326 4297 6462679
SGTC_202 3594-0513 34.79 µM -1.2291597108171 0.134421746076122 no 2944 0.109505965637365 4372 708429
SGTC_482 fipronil 114 µM -1.22925595989441 0.134403060092052 no 2945 0.109487926839007 4417 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_579 4491-1009 110 µM -1.23257568684106 0.133759653268057 no 2946 0.108867056271198 4424 1271041
SGTC_2160 5660466 132.927 µM -1.2332606795231 0.133627156620831 no 2947 0.108739261451227 4232 2859134
SGTC_1503 4585-0012 61.3 µM -1.23351783561332 0.133577438783439 no 2948 0.108691313302445 4337 2922052
SGTC_466 geldanamycin 89.2 µM -1.23441318499261 0.133404433700039 no 2949 0.108524489187418 4290 5288382 HSP90 inhibitor.
SGTC_2695 st077686 51.995 µM -1.2345929082033 0.133369725025144 no 2950 0.108491024842861 4314 2876092
SGTC_772 k072-0172 35.3 µM -1.23465452490986 0.133357826855734 no 2951 0.10847955356137 4369 5861980
SGTC_2335 9018011 154.17 µM -1.23605623300033 0.133087354645287 no 2952 0.108218830991772 4304 6458208
SGTC_3117 9124945 49.47 µM -1.23745119538688 0.132818559164207 no 2953 0.107959811228257 4218 17592065
SGTC_592 k241-0073 46.5 µM -1.23968073574439 0.132389725441005 no 2954 0.107546752625836 4355 4230158
SGTC_2290 7904846 200 µM -1.24419381201504 0.131524595585055 no 2955 0.106714120323558 4348 2962154
SGTC_2543 pimpinellin 60.67 µM -1.24505008849341 0.131360893923094 no 2956 0.106556669544298 4159 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_607 4491-0986 66.8 µM -1.24587754008146 0.131202836672938 no 2957 0.106404678434975 4334 698981 YDR232W HEM1
SGTC_900 1112-0045 141 µM -1.24645373864063 0.131092850611937 no 2958 0.106298931440535 4207 56211 YIL048W NEO1
SGTC_1817 st052116 64.4 µM -1.24891324318963 0.130624091197589 no 2959 0.105848403648732 4343 4361398
SGTC_1014 4130-3005 69.3 µM -1.25339263300316 0.129773340120528 no 2960 0.105031425608451 4343 743608
SGTC_1489 4065-0444 182 µM -1.25592695478271 0.129293710577561 no 2961 0.104571227365818 4346 2877968
SGTC_2476 5806916 10.51 µM -1.25788261175968 0.128924436273326 no 2962 0.104217106526936 4223 2870194
SGTC_2681 menadione 3.18 µM -1.26187678216215 0.128172516633969 no 2963 0.103496563876383 4362 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1836 st055642 81 µM -1.26239312931962 0.12807553484812 no 2964 0.10340368014831 4326 8571
SGTC_215 1287-0124 461.5 µM -1.26302269228243 0.127957357527442 no 2965 0.10329051234396 4345 5560863
SGTC_12 0849-0099 9.267 µM -1.26564808045895 0.127465354173704 no 2966 0.102819552094247 4268 6071388
SGTC_2923 7992654 58.14 µM -1.26684260601182 0.127241933544508 no 2967 0.102605787105814 4332 2985126
SGTC_3238 9133470 49.47 µM -1.26964755494322 0.126718375353039 no 2968 0.102105100941786 4345 3534688
SGTC_1909 st060837 51.5 µM -1.26978067298797 0.126693565523733 no 2969 0.102081383498272 4301 678937
SGTC_327 1273-0057 3.96 µM -1.27214847407493 0.126252832544224 no 2970 0.10166018545738 4237 3108138
SGTC_152 4469-0003 551.229 µM -1.27527893530367 0.125671782930686 no 2971 0.101105265406856 4333 697280
SGTC_1293 1000-1278 195 µM -1.27533297985166 0.125661768050593 no 2972 0.101095704644258 4370 678847
SGTC_3137 9097352 49.47 µM -1.27854709372469 0.125067168471689 no 2973 0.100528295416527 4369 44120435
SGTC_2704 st078022 71.1 µM -1.27933238700319 0.124922191219839 no 2974 0.100390016150858 4375 54697681
SGTC_530 4358-1714 28 µM -1.28196382819431 0.124437242627972 no 2975 0.0999276677042617 4355 1564641
SGTC_730 1436-0052 41.2 µM -1.28252294479355 0.124334372757176 no 2976 0.0998296306550033 4389 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_358 0075-0058 9.45 µM -1.28309941171057 0.124228372950132 no 2977 0.0997286249330373 4310 1069125
SGTC_1013 4112-3890 241 µM -1.28446144093135 0.12397817637984 no 2978 0.099490273458949 4298 705171
SGTC_1775 st081588 35.1725 µM -1.28480776188095 0.123914615576187 no 2979 0.0994297346647741 4340 1426443 YGL099W LSG1
SGTC_595 3909-8003 73.7 µM -1.28552900531426 0.123782317902891 no 2980 0.0993037438120346 4417 699517
SGTC_3154 9100113 49.47 µM -1.28733315652272 0.123451815609147 no 2981 0.0989890957948866 4354 25237525
SGTC_1771 st048882 4.1505 µM -1.28891251561989 0.123163000789348 no 2982 0.0987142512287185 4390 4580403
SGTC_601 0986-0029 62.9 µM -1.28913409123181 0.123122519528585 no 2983 0.0986757367275522 4301 24747981
SGTC_363 0455-0021 3.06 µM -1.29198084648253 0.12260325457257 no 2984 0.0981818888559863 4311 4597466
SGTC_3025 9087895 49.47 µM -1.2932040678668 0.122380604359718 no 2985 0.0979702445602641 4330 17173641
SGTC_872 0588-0139 234 µM -1.29347279799239 0.122331728265542 no 2986 0.0979237931445415 4315 2047100
SGTC_3173 9105693 49.47 µM -1.29632824880263 0.121813230782121 no 2987 0.0974312101192864 4346 17096658
SGTC_2959 9079155 11 µM -1.30346521704095 0.120524046231155 no 2988 0.0962079919343634 4380 16189457
SGTC_1334 1486-0610 236 µM -1.30361242808688 0.120497556316344 no 2989 0.0961828805330091 4424 3742339
SGTC_21 0849-0113 22.993 µM -1.30502295812263 0.120243946111612 no 2990 0.0959425151902745 4333 1560156
SGTC_554 4483-2211 187 µM -1.30570831468203 0.120120856353858 no 2991 0.095825884670684 4428 747107
SGTC_954 1189-0853 2.85 µM -1.30706045514499 0.119878272940137 no 2992 0.0955960901355921 4290 2828194
SGTC_2937 9044753 11.33 µM -1.3079339950827 0.119721737550943 no 2993 0.095447848911045 4297 6465530 YGL099W LSG1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.31023625553963 0.119309871041392 no 2994 0.0950579621196922 4394 5106787 A p450 inhibitor.
SGTC_2800 7887935 81.82 µM -1.31410761734738 0.118619554050642 no 2995 0.0944049955489758 4376 2961002
SGTC_2938 9059746 27.26 µM -1.31426175753636 0.118592127279968 no 2996 0.0943790659981302 4379 6471769
SGTC_1203 3992-3522 103 µM -1.31431183007908 0.118583218639671 no 2997 0.0943706438965845 4476 5322312
SGTC_185 k048-0037 25.491 µM -1.31745291234825 0.118025319014781 no 2998 0.0938434274117643 4412 6827589
SGTC_2598 perillyl alcohol 100 µM -1.31794519283108 0.117938051763351 no 2999 0.0937609978016235 4407 10819 An apoptosis inducer.
SGTC_763 3453-1109 128 µM -1.32354935651247 0.116947810625982 no 3000 0.0928263770123075 4408 1560353
SGTC_288 1315-0019 35.1 µM -1.32623490938097 0.11647537461662 no 3001 0.0923809497294796 4412 6811474
SGTC_1944 st076371 56.9 µM -1.33113909645373 0.115616138312413 no 3002 0.0915716233415554 4358 24208455
SGTC_2689 tacrolimus 100 µM -1.33169632475406 0.11551879495951 no 3003 0.0914799987275345 4391 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1057 3448-5381 134 µM -1.33641300842781 0.114697159961411 no 3004 0.0907071583862718 4364 5497911
SGTC_2424 5537928 59.2 µM -1.33671627352566 0.114644474547341 no 3005 0.0906576339463542 4394 5382802
SGTC_3308 9128332 17.569 µM -1.33994822637575 0.114084065794845 no 3006 0.0901310888207434 4377 17332805 YDL196W YDL196W
SGTC_2005 4024620 188 µM -1.3403948282416 0.114006780390687 no 3007 0.0900585081147091 4351 236743
SGTC_2504 purpurogallin 52.29 µM -1.34439735778223 0.113315798937348 no 3008 0.0894099638929464 4303 5281571 An antioxidant.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.34802328922512 0.112692415469877 no 3009 0.0888254460669744 4451 165506
SGTC_303 1348-1668 34.2 µM -1.34974440276436 0.112397373945717 no 3010 0.088548992045419 4410 5380509
SGTC_248 streptozotocin 5.23457 mM -1.35058001212771 0.112254328976684 no 3011 0.0884150035779356 4428 5300 DNA alkylating agent.
SGTC_1911 st060208 74.3 µM -1.35251597419663 0.111923418580077 no 3012 0.0881051560651783 4440 688783
SGTC_1189 1431-2119 7.28 µM -1.35283969231642 0.111868154184583 no 3013 0.08805342461348 4394 3107275
SGTC_2297 7971671 152.32 µM -1.35342455831792 0.111768356721868 no 3014 0.087960018110479 4397 909016
SGTC_950 1165-0508 94.1 µM -1.35509819405703 0.111483131052472 no 3015 0.0876931370067354 4385 6148369
SGTC_2262 9014885 67.46 µM -1.35682139941701 0.111190002245546 no 3016 0.0874189831410847 4429 6457424
SGTC_3353 9151644 39.2805 µM -1.35908934735852 0.110805050746667 no 3017 0.0870591390127867 4417 4909158
SGTC_291 SEC14.278 35.5 µM -1.36284152509845 0.110170271069738 no 3018 0.0864662304525756 4433 1068044
SGTC_264 promethazine 12.5 mM -1.36297491278769 0.110147753141663 no 3019 0.0864452086124039 4281 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_476 mead acid 10 µM -1.36321893589812 0.1101065667692 no 3020 0.0864067605696095 4473 5312531 An omega 9 fatty acid.
SGTC_3213 9129884 49.47 µM -1.36372194128165 0.110021704067679 no 3021 0.0863275478782606 4391 17190742
SGTC_1668 st014914 51.6 µM -1.36584668491637 0.109663753561415 no 3022 0.0859935448865966 4419 2839556
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.36593185599955 0.109649422441361 no 3023 0.0859801764467407 4458 91467 include heat shock
SGTC_884 0851-0618 334 µM -1.37150456731172 0.108714663014772 no 3024 0.0851088603612578 4429 9642473
SGTC_3225 9130819 49.47 µM -1.37321525136725 0.108428868005579 no 3025 0.0848427198742234 4374 4547121
SGTC_899 1083-0020 478 µM -1.37398397169769 0.108300618120907 no 3026 0.0847233292389835 4465 767123
SGTC_1565 sinapyl alcohol 95.1 µM -1.37407589099864 0.108285290023585 no 3027 0.0847090616084906 4425 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1491 4138-0063 26.5 µM -1.37489961380965 0.108147998964908 no 3028 0.0845812845161018 4424 23883227
SGTC_2854 9024559 71.43 µM -1.37583644846753 0.107992007740175 no 3029 0.0844361371279053 4429 3163529
SGTC_1393 3470-5649 58.2 µM -1.37851324970011 0.107547189715797 no 3030 0.0840224399537805 4411 4108395
SGTC_86 0417-1630 471.922 µM -1.38037975133256 0.107237805691994 no 3031 0.0837348756654232 4399 3634867
SGTC_1005 4092-0690 4.4 µM -1.38321867598973 0.106768467753164 no 3032 0.0832989124566042 4432 1529343
SGTC_1070 indatraline 8.81 µM -1.38379749655108 0.106672957922293 no 3033 0.0832102349129489 4479 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2154 5570129 200 µM -1.38447836928542 0.106560687649527 no 3034 0.0831060134606883 4467 673366
SGTC_2370 9071495 200 µM -1.38468965344858 0.106525865989193 no 3035 0.0830736920784997 4425 21791103
SGTC_1072 oxiconazole 14.9 nM -1.38562870334874 0.106371200931635 no 3036 0.0829301544607549 4416 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2231 micatex 6.853 µM -1.38579171573058 0.106344368704415 no 3037 0.0829052563672243 4452 20737 An antifungal of unknown mechanism.
SGTC_2440 5628896 157.78 µM -1.38977152266075 0.105690798693611 no 3038 0.0822991340837191 4397 5522048
SGTC_340 k038-0059 454 µM -1.39281798063782 0.105192470577117 no 3039 0.0818374198484144 4400 23733424
SGTC_3270 9137563 49.47 µM -1.39466745400026 0.10489077131678 no 3040 0.08155807181705 4419 17015724
SGTC_729 4092-0585 94.1 µM -1.39591572375718 0.104687499082922 no 3041 0.0813699375496481 4438 2169061
SGTC_1158 4092-0494 91.8 µM -1.39767507944791 0.104401484653878 no 3042 0.081105330517282 4511 1148199
SGTC_1341 1486-1360 280 µM -1.40075706038005 0.103901819592674 no 3043 0.0806433665617392 4420 3976547
SGTC_383 2324-0395 7.37 µM -1.40427890799595 0.103332967322698 no 3044 0.0801179062617427 4425 3146421
SGTC_1301 naphtanilide LB 4.81 µM -1.40471293827243 0.103263019124839 no 3045 0.080053328418473 4496 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2801 7907800 81.82 µM -1.40731498002979 0.102844395578203 no 3046 0.0796670046397525 4423 6620925
SGTC_1487 3970-0795 2.82 µM -1.40746158302429 0.102820846438634 no 3047 0.0796452806146482 4490 3765103
SGTC_2727 riluzole 51.77 µM -1.41041424699325 0.102347387842221 no 3048 0.0792087005063379 4480 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1609 st001574 46.4 µM -1.41958716286767 0.100886631520189 no 3049 0.0778639524207915 4440 3960012
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.41984714100981 0.100845453535724 no 3050 0.0778260937274346 4451 6708561
SGTC_133 0724-0033 378.92 µM -1.42093539019105 0.100673218567963 no 3051 0.0776677716739989 4309 280309
SGTC_1440 4100-1550 40 µM -1.42177556278527 0.100540393011305 no 3052 0.0775457079615528 4467 742806
SGTC_2173 5763948 167 µM -1.42318193730837 0.100318340991757 no 3053 0.0773417101908696 4414 2867177
SGTC_1930 st074634 34.3 µM -1.42440446929296 0.100125606792366 no 3054 0.0771647106086641 4360 684253 YOR116C RPO31
SGTC_2865 9030313 51.95 µM -1.42578735069105 0.0999079192514332 no 3055 0.0769648666323631 4435 42562754
SGTC_1467 k284-1082 293 µM -1.42966943085506 0.0992986656421548 no 3056 0.0764059589265508 4413 3334705
SGTC_1407 3909-7909 12.3 µM -1.43107512064464 0.0990787279352059 no 3057 0.0762043434011763 4475 4411780
SGTC_3171 9103192 49.47 µM -1.43241014543097 0.0988701767346947 no 3058 0.0760132383661815 4540 13018434
SGTC_171 k064-0041 9.68 µM -1.43412556872908 0.0986026732443197 no 3059 0.0757682162758271 4446 53325
SGTC_2430 5571206 200 µM -1.4351304780102 0.0984462137628902 no 3060 0.075624959983879 4433 1731771
SGTC_1693 xanthone 101.9 µM -1.43602479955969 0.0983071251983812 no 3061 0.0754976423129486 4491 7020 An insecticide.
SGTC_1821 st053465 65.6 µM -1.44187099443482 0.0974014450781327 no 3062 0.0746693851030395 4476 675086
SGTC_2331 7980721 200 µM -1.44296978790473 0.0972319078140816 no 3063 0.074514491067725 4418 2981221
SGTC_2235 salicylic acid 500 µM -1.44712612600047 0.0965925683186864 no 3064 0.0739308009910988 4517 338 A COX inhibitor and kinase inhibitor.
SGTC_2514 salinomycin 42.74 µM -1.44944060555671 0.096237890001406 no 3065 0.0736072879306382 4500 23682228 A polyether potassium ionophore.
SGTC_2265 7929201 200 µM -1.45407102980466 0.095531183944399 no 3066 0.0729633072334733 4440 1265108
SGTC_1092 toremifene 6.32 µM -1.4562844604799 0.0951947173930923 no 3067 0.0726569997355492 4464 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2070 5230947 200 µM -1.45758220999994 0.0949978510075656 no 3068 0.0724778680732966 4558 2835538
SGTC_2014 4013930 200 µM -1.46309948535246 0.0941642371070334 no 3069 0.0717200793410241 4447 64556
SGTC_1783 st039459 87.517 µM -1.46388014047584 0.0940467238253104 no 3070 0.0716133502516891 4538 729761
SGTC_91 0417-1751 58.384 µM -1.46631980412934 0.093680174831155 no 3071 0.071280591336766 4572 6795624
SGTC_2455 5377712 9.75 µM -1.47041330156056 0.0930675159037929 no 3072 0.070724925495581 4468 2243908
SGTC_2913 7966556 36.57 µM -1.47084393791486 0.0930032366818687 no 3073 0.0706666634294058 4379 2976516
SGTC_2858 9025781 8.96 µM -1.47440389426399 0.0924731139915648 no 3074 0.0701864382839043 4326 4894980 YPL153C RAD53
SGTC_3072 9116419 49.47 µM -1.47672523543388 0.0921286431026026 no 3075 0.0698746523862724 4495 17170162
SGTC_3052 9092717 49.47 µM -1.48261396261534 0.091259060046888 no 3076 0.0690885026493366 4494 25237534
SGTC_2030 5175110 200 µM -1.48297134393081 0.091206482411613 no 3077 0.0690410122406069 4476 2831986
SGTC_830 4076-0286 57.8 µM -1.48357059123959 0.0911183720707112 no 3078 0.0689614380751637 4525 6866659
SGTC_495 decylubiquinone 155 µM -1.48499783861518 0.0909087709732776 no 3079 0.0687721983289606 4482 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_573 3702-0553 84.7 µM -1.48533559271876 0.0908592218414618 no 3080 0.0687274739156146 4432 1222756
SGTC_728 3030-5151 22.5 µM -1.48770069816223 0.090512817941224 no 3081 0.068414921703091 4563 3125388
SGTC_199 4063-0024 41.6 µM -1.49128462531266 0.0899897700019344 no 3082 0.0679433918704511 4524 306215
SGTC_777 1315-0167 517 µM -1.49128750551876 0.0899893505620749 no 3083 0.0679430139394901 4516 4221767
SGTC_1935 st074532 41.6 µM -1.49171615841002 0.0899269427149795 no 3084 0.0678867856445469 4454 2829742
SGTC_2210 7115885 190.385 µM -1.49728801358633 0.0891186569160812 no 3085 0.0671591662053531 4568 2927039
SGTC_1765 st044815 90.4 µM -1.502122960356 0.0884216634652742 no 3086 0.0665326780875899 4517 645695
SGTC_427 1354-0053 47.3 µM -1.50315162318158 0.0882738995039785 no 3087 0.0663999746140134 4518 6813657
SGTC_3140 9094243 49.47 µM -1.50510808853182 0.0879933678467158 no 3088 0.0661481449083454 4452 19291112
SGTC_2428 5615643 7.78 µM -1.50623200858006 0.0878325132723267 no 3089 0.0660038126079951 4483 2253075
SGTC_3248 9135562 49.47 µM -1.50812393052669 0.0875622383459386 no 3090 0.0657614057769137 4493 17650701
SGTC_204 PMA1.184 62.41 µM -1.50912861673405 0.0874189640871341 no 3091 0.0656329588955889 4465 2252213 YGL008C PMA1
SGTC_409 arachidonic acid 100 µM -1.5098301566044 0.0873190241089341 no 3092 0.0655433839892657 4509 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_472 calcifediol 10 µM -1.51030318608223 0.0872516854298043 no 3093 0.0654830395675939 4538 5283731 A vitamin D metabolite.
SGTC_2814 7977482 42.97 µM -1.51093544285144 0.0871617403147433 no 3094 0.0654024497971763 4489 6456762
SGTC_2213 7173844 200 µM -1.51125712104802 0.0871160048223541 no 3095 0.0653614770500287 4514 892728
SGTC_865 0488-0499 301 µM -1.51170946679586 0.0870517216314209 no 3096 0.065303894623847 4448 9634651
SGTC_1215 3852-0577 11.2 µM -1.51374720095339 0.0867625769466692 no 3097 0.065044984252277 4524 2884876
SGTC_2612 dictamnine 15.46 µM -1.51723350215869 0.0862695527731946 no 3098 0.0646038702955773 4429 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1522 st012842 45.6 µM -1.51754612848167 0.0862254445038964 no 3099 0.064564428180055 4343 3491067 YOR116C RPO31
SGTC_2312 7706453 155.7 µM -1.51799962319039 0.0861614911788757 no 3100 0.0645072468282131 4506 976098
SGTC_66 0109-0187 42.4 µM -1.51898455861843 0.0860227145543769 no 3101 0.0643831913974203 4369 759417
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.52151752878879 0.0856665892468122 no 3102 0.0640650079570745 4505 1377
SGTC_1197 1601-0112 267 µM -1.52258240450494 0.0855172020538451 no 3103 0.0639316073277033 4478 7350313
SGTC_3011 9081274 71.4286 µM -1.52785355318762 0.08478060536253 no 3104 0.0632744511886048 4508 6625322
SGTC_2816 7982706 58.44 µM -1.53050487809474 0.0844119090960434 no 3105 0.0629459034727827 4493 2981853
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.53503789840955 0.0837843309365466 no 3106 0.06238725954457 4521 688667
SGTC_2868 9035608 32.47 µM -1.53532053310267 0.083745317701232 no 3107 0.0623525564422894 4505 6462614
SGTC_3229 9132204 49.47 µM -1.53647878992826 0.0835855812641951 no 3108 0.0622104979237737 4613 17682924
SGTC_1420 4'-methoxyflavone 42 µM -1.53665886824167 0.0835607670490413 no 3109 0.062188434274696 4506 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1905 st060207 84.5 µM -1.53777535353486 0.0834070424887537 no 3110 0.0620517758976356 4509 1948547
SGTC_2710 st078562 53.7235 µM -1.53849942356779 0.0833074617624238 no 3111 0.0619632746807647 4480 17250908
SGTC_73 0327-0325 16.231 µM -1.54174437099463 0.0828622845345097 no 3112 0.0615678624799254 4329 53298
SGTC_3058 9093861 49.47 µM -1.54326810984863 0.0826538600097508 no 3113 0.0613828688826264 4522 17217477
SGTC_1637 st007924 17.4 µM -1.54514236124135 0.0823980320922931 no 3114 0.061155916241533 4428 683336
SGTC_3090 9117696 49.47 µM -1.54553235538833 0.0823448744469293 no 3115 0.0611087744721535 4479 7923821
SGTC_2286 7945697 125 µM -1.54675865525518 0.0821778935001725 no 3116 0.0609607266612415 4497 1245733
SGTC_1865 st057639 52.2 µM -1.54886712224067 0.0818913874113699 no 3117 0.0607068329369164 4523 688818
SGTC_1234 0326-0494 15.5 µM -1.5502243060829 0.081707367003333 no 3118 0.0605438439323635 4576 1547813
SGTC_98 0074-0023 107.663 µM -1.5517938356737 0.0814949435650695 no 3119 0.060355780695635 4519 3563821
SGTC_1989 st071868 50.2 µM -1.55404614119628 0.0811908398082076 no 3120 0.0600867054222429 4517 16414057
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.56336392784841 0.0799418561297428 no 3121 0.0589835098181949 4567 1273210
SGTC_2945 9067681 61.76 µM -1.56355389837601 0.0799165439001972 no 3122 0.0589611843404814 4558 16456930
SGTC_2384 9036245 200 µM -1.56765862676938 0.0793710970438209 no 3123 0.0584804110373753 4487 6462766
SGTC_519 k048-0011 62.8 µM -1.57212075786341 0.0787813592448535 no 3124 0.0579612741433083 4549 6836379
SGTC_3053 9095903 49.47 µM -1.57225729042529 0.078763366902345 no 3125 0.0579454468568924 4632 17174018
SGTC_2283 7944793 200 µM -1.57962498283717 0.0777970585830086 no 3126 0.0570963872265158 4527 2970533
SGTC_503 tyrphostin 8 294 µM -1.58281499789764 0.0773814749135347 no 3127 0.0567318186432474 4548 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1835 st008666 49.2 µM -1.58317669325858 0.0773344611790416 no 3128 0.056690598548889 4506 690455
SGTC_956 1185-0240 191 µM -1.58475904510032 0.0771290396483534 no 3129 0.0565105454059887 4515 1416193
SGTC_3130 9127414 49.47 µM -1.58653914507503 0.0768984422700207 no 3130 0.0563085298008406 4577 1494646
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.59413024152436 0.0759209575559411 no 3131 0.0554534333764203 4621 688801
SGTC_2870 9038528 12.99 µM -1.60116242975648 0.0750239109111575 no 3132 0.0546704738802035 4563 6463316
SGTC_1252 0493-0875 34.8 µM -1.60740107271091 0.0742348782931135 no 3133 0.0539832074646118 4534 3960963
SGTC_103 0844-0104 51.839 µM -1.60881811881653 0.0740565437439328 no 3134 0.0538280588998585 4371 5375804
SGTC_3280 9140961 49.47 µM -1.61041157833245 0.073856398806239 no 3135 0.0536540172943931 4574 4901226
SGTC_3007 9078383 71.4286 µM -1.61120043826362 0.0737574679252164 no 3136 0.0535680211650157 4563 6496995
SGTC_1276 0871-0068 94.2 µM -1.6180538599172 0.0729022387546139 no 3137 0.0528254954415009 4562 3414906
SGTC_632 0781-2353 4.65 µM -1.61911767186287 0.072770170481944 no 3138 0.0527109736053115 4575 6811515 YHR007C ERG11
SGTC_1166 k206-0078 225 µM -1.62167366516441 0.0724536023750951 no 3139 0.0524366202090109 4570 5404595
SGTC_1074 carmofur 3.8 µM -1.62361992304709 0.0722132603438498 no 3140 0.0522284753679439 4588 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2774 tamoxifen 10.92 µM -1.62649035153683 0.0718599089011941 no 3141 0.0519226921148818 4547 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2712 st079126 47.7 µM -1.63102688890762 0.0713041643122742 no 3142 0.051442322965744 4559 3152970
SGTC_971 1315-0384 26.7 µM -1.63804854193679 0.0704504960801224 no 3143 0.0507057840502051 4586 6769120
SGTC_1109 tnp00067 928.257 nM -1.63977765563132 0.07024148698094 no 3144 0.050525702852945 4564 676295
SGTC_3021 9087658 49.47 µM -1.64298955918307 0.0698545096049151 no 3145 0.0501925467463118 4589 25237042
SGTC_167 3672-0051 66.205 µM -1.64425674641478 0.0697022881676574 no 3146 0.0500615898816679 4480 3237971
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.64489980774922 0.0696251378696056 no 3147 0.0499952372947441 4575 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_253 dyclonine 31.25 µM -1.64538139669089 0.0695674030420253 no 3148 0.049945591751906 4649 3180 An oral anasthetic.
SGTC_314 1671-0008 2.74 µM -1.64722361527242 0.0693468906017267 no 3149 0.0497560457757856 4439 3913060
SGTC_2840 9008771 71.43 µM -1.65387059668126 0.0685557250264796 no 3150 0.0490769040223593 4514 2992978
SGTC_2785 7756463 72.73 µM -1.65671597795689 0.0682191854923651 no 3151 0.0487884555473437 4537 2201551
SGTC_1205 4161-2785 76 µM -1.6568613624556 0.0682020243357242 no 3152 0.0487737537601004 4566 3498106
SGTC_300 r073-0011 5.04 µM -1.65805698395116 0.0680610197687354 no 3153 0.048652982598977 4576 2735780
SGTC_2973 9094665 17.96 µM -1.66137423732879 0.0676709808104983 no 3154 0.0483191543150364 4548 25237061 YIL048W NEO1
SGTC_1822 st052468 42 µM -1.66996289347904 0.0666691593455407 no 3155 0.0474633526967374 4592 2873678
SGTC_2194 5927483 104.545 µM -1.67138290471687 0.0665046339751305 no 3156 0.0473230351964739 4611 760979
SGTC_823 0417-1665 178 µM -1.67764263602663 0.0657831130880462 no 3157 0.0467084420831718 4608 3429856
SGTC_1254 0550-0035 264 µM -1.67771972960717 0.0657742649587064 no 3158 0.0467009129914946 4560 15121435
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.68363639488012 0.0650979498636036 no 3159 0.0461259802719124 4606 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1939 st074455 53.6 µM -1.68523001527905 0.064916713918513 no 3160 0.0459721010937176 4528 1644229
SGTC_2837 9008476 45.46 µM -1.68628649849873 0.0647967804710126 no 3161 0.0458703151460349 4544 2992805
SGTC_3068 9116768 49.47 µM -1.69004871077459 0.0643710857260396 no 3162 0.0455093179966993 4548 41904888
SGTC_3282 9108498 15.4605 µM -1.69518904372704 0.0637929734251254 no 3163 0.0450197823307507 4570 16459645
SGTC_1298 1079-1278 263 µM -1.69564154749735 0.0637422761992356 no 3164 0.0449768922292197 4565 2840950
SGTC_177 1327-0068 8.361 µM -1.70769146677411 0.0624037351663359 no 3165 0.0438468031671149 4582 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2664 lyso-paf C-16 73.48 µM -1.71219407657153 0.0619092343959948 no 3166 0.0434304543492459 4587 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1766 st045414 44.774 µM -1.71331139591349 0.0617869992515262 no 3167 0.0433276334892838 4590 253960
SGTC_1096 rimcazole 32.2 µM -1.72037224134025 0.0610188923447692 no 3168 0.0426823997294391 4569 18528119 A dopamine reuptake inhibitor.
SGTC_625 k213-0058 121 µM -1.72109829325617 0.0609403346227642 no 3169 0.0426164944796296 4653 3655420
SGTC_842 0271-0008 11.1 µM -1.72180278665625 0.0608641851038972 no 3170 0.0425526248167265 4612 1221709
SGTC_1485 3909-9022 254 µM -1.7229268724001 0.0607428354485577 no 3171 0.0424508750451429 4654 714516
SGTC_2203 7227154 166.4 µM -1.72417059802415 0.0606087907659726 no 3172 0.0423385251391374 4612 896304
SGTC_1789 tunicamycin 25 nM -1.72455737611444 0.0605671522905877 no 3173 0.0423036352520963 4517 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1759 st043059 70 µM -1.72541113634515 0.0604753202186417 no 3174 0.0422267028932881 4612 669426
SGTC_2523 spermine 47.74 µM -1.72863114143327 0.0601299503461228 no 3175 0.0419375662082458 4593 1103 A DNA binding polyamine.
SGTC_399 oxolinic acid 75 µM -1.73334184832691 0.0596274758377059 no 3176 0.0415174634057342 4595 4628 A DNA gyrase inhibitor.
SGTC_1475 4092-1048 11.7 µM -1.74021907757369 0.0588998215708996 no 3177 0.0409102784943475 4611 2881759
SGTC_2776 terbinafine 19.92 µM -1.75244297129266 0.0576236748468241 no 3178 0.0398488339666898 4615 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3001 9076041 71.4286 µM -1.75710475844553 0.0571427614675867 no 3179 0.0394499774065163 4605 16004211
SGTC_2162 5663267 200 µM -1.75768693436729 0.0570829263244972 no 3180 0.0394003960895387 4620 6456493
SGTC_1281 0884-0031 11.8 µM -1.76859595934647 0.0559708101945735 no 3181 0.0384806627797697 4624 1548255
SGTC_2970 9090938 41.86 µM -1.77691943307686 0.0551338278203307 no 3182 0.0377907482710092 4632 17217104
SGTC_866 0495-0101 262 µM -1.77807927226281 0.0550179870378609 no 3183 0.037695418109077 4618 635694
SGTC_1628 st004252 77.7 µM -1.79167667800679 0.0536742222511258 no 3184 0.0365923862403367 4617 692968
SGTC_2184 6075246 200 µM -1.79232455157971 0.053610850734439 no 3185 0.0365404963501265 4609 2267320
SGTC_1739 st037196 92.5 µM -1.79321357636089 0.0535239875865965 no 3186 0.0364693900322547 4623 612214
SGTC_124 0136-0217 7.121 µM -1.79524890026498 0.053325543881601 no 3187 0.0363070262749652 4669 3976905
SGTC_3003 9075612 71.4286 µM -1.79644473642938 0.0532092223122705 no 3188 0.0362119071892211 4637 6501993
SGTC_3349 9149703 23.001 µM -1.79977387465566 0.0528864491318276 no 3189 0.0359481753782376 4634 4910494
SGTC_1451 4152-0210 104 µM -1.81191455915637 0.05172250267741 no 3190 0.0349996997138456 4648 659563
SGTC_2276 7947513 42.08 µM -1.81330261437152 0.051590734921813 no 3191 0.0348925801503441 4549 2105100
SGTC_732 3970-1727 52.7 µM -1.82078814003341 0.0508847304272921 no 3192 0.034319533909988 4671 1275699
SGTC_2643 anethole 100 µM -1.82265735955062 0.0507096388084649 no 3193 0.034177651137889 4641 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1448 4255-0083 152 µM -1.82268343747942 0.0507071994613218 no 3194 0.0341756751132015 4663 5399660
SGTC_3020 9089140 49.47 µM -1.82795667542449 0.0502158541297021 no 3195 0.0337780270392096 4645 17217859
SGTC_1629 st005085 44.9 µM -1.82965538061927 0.0500583842715462 no 3196 0.0336507434485516 4601 24207091
SGTC_1032 k061-1018 98.7 µM -1.83080635008482 0.0499519134225452 no 3197 0.0335647261032048 4657 4005393
SGTC_2411 st077133 39.94 µM -1.84390549085467 0.048752854660036 no 3198 0.0325984573764723 4602 1403142 YNL221C POP1
SGTC_2557 derrustone 83.84 µM -1.84753874349383 0.0484243841193769 no 3199 0.0323345491822503 4619 629853 An antioxidant.
SGTC_1502 4534-4282 27.7 µM -1.84857892106848 0.048330671648416 no 3200 0.0322593193713227 4653 3278949
SGTC_1677 st019204 53.9 µM -1.85425976450964 0.047821425546544 no 3201 0.0318510027387175 4636 3945625
SGTC_116 0155-0182 31.788 µM -1.85557979058382 0.0477037121169587 no 3202 0.0317567382329362 4512 771486
SGTC_24 0417-1663 219 µM -1.8586537309172 0.0474304925188114 no 3203 0.0315381178939929 4675 4329390
SGTC_2553 4-methylesculetin 85.09 µM -1.85985084768547 0.0473244295594814 no 3204 0.0314533155378233 4632 5319502
SGTC_1256 0570-0116 285 µM -1.86446611400263 0.0469173008551011 no 3205 0.0311281379669211 4641 410638
SGTC_1695 st026914 34.495 µM -1.86573435963435 0.0468059178687404 no 3206 0.0310392699761985 4650 3289191
SGTC_3339 9145883 14.936 µM -1.86840615456936 0.0465719630563878 no 3207 0.0308527399322693 4587 2030670
SGTC_2464 5717415 7.67 µM -1.86961843874324 0.046466119767177 no 3208 0.0307684114443433 4616 5285744
SGTC_832 4083-0019 164 µM -1.88213080473194 0.0453849224810639 no 3209 0.0299091288802329 4682 1990758
SGTC_959 1222-0044 107 µM -1.88311604492143 0.0453006541734393 no 3210 0.0298423216341812 4649 6083612
SGTC_1268 0828-0275 2.46 µM -1.88452534367943 0.0451803346630975 no 3211 0.0297469750031762 4682 745337
SGTC_1820 st053765 18.6 µM -1.89195323667483 0.0445504178818136 no 3212 0.0292486058505332 4677 3690829
SGTC_2626 ethyl orsellinate 100 µM -1.89289963391981 0.0444706700072801 no 3213 0.0291856089795494 4592 75653 A natural product.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.89371478918703 0.0444020734308563 no 3214 0.0291314386113522 4616 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3075 9116269 49.47 µM -1.89501306599768 0.0442929974904889 no 3215 0.0290453353372542 4637 17015205 YNL244C SUI1
SGTC_2164 5685496 200 µM -1.89971167056719 0.0439000437459711 no 3216 0.0287354839694946 4609 759046
SGTC_2252 omeprazole 400 µM -1.90544072906611 0.0434247207359779 no 3217 0.0283614025634659 4693 4594 A proton pump inhibitor.
SGTC_3347 9188721 44.724 µM -1.90905972177962 0.0431266108439441 no 3218 0.0281271939555261 4654 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_882 0843-0131 351 µM -1.91300186919847 0.0428037648693573 no 3219 0.0278739065795905 4682 5425421
SGTC_2246 7293507 91.5585 µM -1.92034397532945 0.0422076844815984 no 3220 0.0274072325773777 4680 887656
SGTC_2196 6573537 42.6665 µM -1.93400249305533 0.0411166756322518 no 3221 0.0265564106627646 4696 2903087
SGTC_3196 9111891 49.47 µM -1.93561938630983 0.0409890497470142 no 3222 0.0264571671135284 4637 18891510
SGTC_690 glyoxal 20.3 µM -1.93768114052006 0.0408267760212158 no 3223 0.0263310681163485 4487 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1406 3909-7906 11.9 µM -1.93994567511809 0.0406491431837978 no 3224 0.026193146175035 4685 X1406
SGTC_1123 mangostin 811.285 nM -1.94368894778919 0.0403568921516287 no 3225 0.0259664861058817 4663 5281650 An antioxidant.
SGTC_979 1426-2828 121 µM -1.94871449759544 0.0399672146113834 no 3226 0.0256647647379319 4703 747872
SGTC_3220 9131269 49.47 µM -1.94950100435234 0.0399065070813908 no 3227 0.0256178114919601 4683 17722206
SGTC_281 1672-3440 14.9 µM -1.95233995381865 0.0396880023645754 no 3228 0.0254489284513783 4696 6833000
SGTC_2539 epi(13)torulosol 80 µM -1.95507459084504 0.0394784470786607 no 3229 0.0252871334220102 4630 6708597
SGTC_1825 st052143 62.6 µM -1.95819373935494 0.0392405263972344 no 3230 0.0251036417439276 4702 674173
SGTC_2066 5222451 176 µM -1.95965160414699 0.0391297250450663 no 3231 0.0250182626837141 4616 2281147
SGTC_154 3389-1638 511.116 µM -1.96109701159632 0.039020122034763 no 3232 0.0249338536413016 4675 5238686
SGTC_3263 9137018 49.47 µM -1.96442821375742 0.0387684738408306 no 3233 0.0247402268062611 4638 43844957
SGTC_1523 st012844 44.7 µM -1.96576931619879 0.0386675372272799 no 3234 0.0246626318541213 4681 4274103
SGTC_1081 sertraline 6 µM -1.96623114803489 0.0386328275594351 no 3235 0.0246359579991899 4662 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_294 k038-0071 157 µM -1.96907718471938 0.0384194892670613 no 3236 0.0244721141811332 4695 24152826
SGTC_1235 benzylparaben 21.5 µM -1.9693512154403 0.0383989987661837 no 3237 0.0244563868597855 4710 7180
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.97538427706456 0.0379501324135935 no 3238 0.0241122778556274 4716 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1437 4092-1038 11.6 µM -1.98899522953257 0.0369531774802018 no 3239 0.0233508647598941 4719 3977136
SGTC_1292 0kpi-0043 232 µM -1.99222632780086 0.0367196826223931 no 3240 0.0231731153944061 4691 3333905
SGTC_3077 9117319 49.47 µM -1.99230410437431 0.0367140770167381 no 3241 0.0231688508242355 4645 17154678
SGTC_513 4245-1575 41.7 µM -1.99514966808571 0.0365094689349792 no 3242 0.0230132793153576 4518 719745
SGTC_2401 5128683 200 µM -1.99999018916487 0.0361635590535487 no 3243 0.0227506616498467 4648 708373
SGTC_609 0986-0026 86.3 µM -2.00001444110122 0.0361618327586572 no 3244 0.0227493522704262 4682 2848610
SGTC_2024 5144227 134 µM -2.00322401520604 0.03593396436859 no 3245 0.0225766245438869 4666 3475211
SGTC_2745 rifampicin 24.3 µM -2.00326529847736 0.0359310410823813 no 3246 0.0225744100491794 4765 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.00447458199128 0.0358454975919975 no 3247 0.0225096235258903 4692 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_169 k015-0017 16.025 µM -2.04393312890979 0.0331445283288647 no 3248 0.0204800768961123 4637 1840002
SGTC_600 1495-0418 41.6 µM -2.0516749215053 0.0326347821322013 no 3249 0.0201006327834291 4697 5377768
SGTC_40 0327-0103 19.753 µM -2.05431734348164 0.0324622829087141 no 3250 0.0199724936013812 4561 409036
SGTC_2288 7946289 167.31 µM -2.0742444296942 0.0311855129530117 no 3251 0.0190283079270467 4676 1246052
SGTC_1724 st037281 8.293 µM -2.08051727842194 0.0307923003121363 no 3252 0.0187390562484792 4664 574124 YDL195W SEC31
SGTC_2764 methyldopa 94.69 µM -2.08253432384644 0.0306667375844843 no 3253 0.0186468455407336 4672 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1051 3253-3903 78 µM -2.0944353386105 0.0299344925190175 no 3254 0.0181106087644137 4706 5509239
SGTC_1449 4112-4002 201 µM -2.10201341124184 0.0294758299468021 no 3255 0.0177760505091565 4719 2059539
SGTC_299 1273-0059 1.44 µM -2.10632428858218 0.0292175279510875 no 3256 0.0175880964497804 4477 2848077
SGTC_1118 chelidonine 707.474 nM -2.11929643561706 0.0284515725684274 no 3257 0.0170327113518954 4690 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2555 cholic acid 100 µM -2.12511709160461 0.0281133553617024 no 3258 0.016788421879064 4681 6708657 Influences liver metabolism.
SGTC_1025 k007-0731 70 µM -2.13941655550728 0.0272966574587372 no 3259 0.0162009736596412 4690 6256118
SGTC_2344 7990960 76.95 µM -2.15849036248852 0.0262381691937379 no 3260 0.0154448634574908 4682 140813
SGTC_1040 k898-0338 155 µM -2.16071380486396 0.0261170444545257 no 3261 0.0153587269327014 4694 20969351
SGTC_1987 st072290 61.9 µM -2.16182305174387 0.0260567919244278 no 3262 0.0153159089734662 4732 54697379
SGTC_3099 9120367 49.47 µM -2.16373548305113 0.0259531847131771 no 3263 0.0152423280651082 4738 24824940
SGTC_2486 5283202 22.39 µM -2.16890004826275 0.0256751118207612 no 3264 0.0150451365452803 4717 1377751
SGTC_3116 9124943 49.47 µM -2.17340753054768 0.0254344602985071 no 3265 0.0148748292802167 4713 41905195 YPL160W CDC60
SGTC_1428 4049-0204 61.7 µM -2.18801551134928 0.0246674955856986 no 3266 0.014334236230276 4742 X1428
SGTC_2128 5255449 168.493 µM -2.18883233420886 0.0246251889290564 no 3267 0.0143045143289497 4656 736008
SGTC_2705 st078069 42.8 µM -2.20031296976894 0.0240369725532187 no 3268 0.0138923488598893 4718 1530061
SGTC_1779 st039427 55 µM -2.20402127513797 0.0238495164154917 no 3269 0.0137614239525668 4703 1124498
SGTC_781 4335-2806 94.4 µM -2.21077791013976 0.023511125109889 no 3270 0.01352561012755 4735 845254
SGTC_3340 9146634 11.102 µM -2.21170960860516 0.0234647814452894 no 3271 0.0134933680823239 4716 4907387
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -2.21806251062317 0.0231508257886351 no 3272 0.0132752852611133 4726 689007
SGTC_726 3448-4391 34.2 µM -2.22387915152725 0.0228664806211838 no 3273 0.0130782880632845 4751 1356692
SGTC_518 1021-0119 62.6 µM -2.22754510662555 0.0226887872391123 no 3274 0.0129554323480171 4703 1097762
SGTC_262 fenpropimorph 62.5 µM -2.23721533981227 0.0222256350768602 no 3275 0.0126361346276825 4762 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1855 st056195 39.6 µM -2.2486640829247 0.0216876397979406 no 3276 0.0122669379747158 4687 4028379
SGTC_523 1934-0222 13.7 µM -2.25293076738596 0.0214899753850163 no 3277 0.0121317572806129 4719 1361595
SGTC_2072 5231554 129 µM -2.26799934654597 0.0208040299670698 no 3278 0.0116646232522282 4768 789545
SGTC_1221 2958-7315 257 µM -2.27321660261743 0.0205708936611549 no 3279 0.0115065651377267 4748 4562705
SGTC_1848 st056003 16.4 µM -2.27434799871036 0.0205206296058353 no 3280 0.0114725356871405 4723 146492
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.28950314459641 0.0198573092914842 no 3281 0.0110250677050011 4759 688664
SGTC_1954 st077032 68.9 µM -2.30680948438525 0.019122175044188 no 3282 0.010532721642128 4694 698907
SGTC_2237 6667747 47.222 µM -2.31394720808661 0.0188257905591139 no 3283 0.0103353090689444 4725 729940 YDL015C TSC13
SGTC_95 0471-0001 561.058 µM -2.3200692507654 0.0185747035037342 no 3284 0.0101685657175847 4731 4015405
SGTC_2729 fluphenazine 10.66 µM -2.33137812688794 0.0181183798017663 no 3285 0.00986671492934679 4730 3372 An atypical antipsychotic.
SGTC_1035 k081-0041 55.2 µM -2.33577789326572 0.0179434451870271 no 3286 0.00975141018082398 4737 731709
SGTC_1384 3089-0840 101 µM -2.34638014813345 0.0175278076603662 no 3287 0.00947838092798924 4740 1069836
SGTC_612 0302-0167 22.4 µM -2.34721989307052 0.0174952415012208 no 3288 0.00945704431257781 4734 235821
SGTC_1901 st060216 58.6 µM -2.35294049880335 0.0172747623435921 no 3289 0.00931280711549125 4738 688792
SGTC_2842 9000675 19.48 µM -2.36498616621233 0.0168182587460216 no 3290 0.00901537221338008 4701 2989072
SGTC_2377 9073351 62.6 µM -2.36911352168914 0.0166642330811468 no 3291 0.00891538978918188 4731 7337946 YHR072W ERG7
SGTC_1445 4239-0156 97.7 µM -2.37610384040481 0.0164061195595454 no 3292 0.00874826908255453 4755 4008346
SGTC_142 0335-0849 62.6745 µM -2.3899679869738 0.0159043092091969 no 3293 0.00842492072154064 4705 3889043 YPR107C YTH1
SGTC_551 k048-0028 34.9 µM -2.39356414031954 0.0157763171037763 no 3294 0.00834278183137531 4718 6836383
SGTC_448 monastrol 171 µM -2.40036023006038 0.0155368460780387 no 3295 0.00818947222801563 4678 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1645 Cervolide 78 µM -2.40917742572805 0.0152308128578723 no 3296 0.00799426151610881 4773 23173 A fragrance.
SGTC_1126 isoteolin 1.0172 µM -2.40949575482605 0.0152198616113643 no 3297 0.00798729095425739 4717 133323
SGTC_1978 st071761 42 µM -2.42050284277779 0.014845331084256 no 3298 0.00774952905317945 4756 5147680
SGTC_2600 tangeritin 87.95 µM -2.43974390695462 0.0142096504657181 no 3299 0.00734883853267219 4713 68077 A bioactive flavone.
SGTC_2045 5106652 78.05 µM -2.44273146490026 0.0141130819892568 no 3300 0.00728828945824757 4767 673349
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.45871110043706 0.0136061097791513 no 3301 0.00697183867184888 4731 364106
SGTC_3004 9076122 71.4286 µM -2.48001706024331 0.0129546540692531 no 3302 0.00656880483603347 4756 44782551
SGTC_2752 diclazuril 33.15 µM -2.48204008805005 0.0128942231665125 no 3303 0.00653162890504434 4696 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1509 1326-1131 80 µM -2.48483776342377 0.0128110541453501 no 3304 0.00648052439100043 4746 768313
SGTC_1404 3909-7820 48.3 µM -2.49238014937151 0.0125891428949563 no 3305 0.00634450732585167 4764 23741373
SGTC_2625 euphol 100 µM -2.51888766548583 0.011835432219626 no 3306 0.00588631045271967 4742 6708538 A triterpene alcohol.
SGTC_778 3456-2434 196 µM -2.53245567727648 0.0114650190300762 no 3307 0.00566333442720397 4711 5539063
SGTC_3343 9148379 18.9835 µM -2.55471296897323 0.0108791797799386 no 3308 0.00531376971164368 4775 1955036
SGTC_1919 st067113 52.3 µM -2.56193957823415 0.0106946537744837 no 3309 0.00520447127465925 4722 1268243
SGTC_3056 9094900 49.47 µM -2.56757602259128 0.0105526291733607 no 3310 0.00512061651290013 4760 25236784
SGTC_1062 mesoridazine 14.2 µM -2.57063574436022 0.010476221967671 no 3311 0.00507560175466738 4793 4078 A neuroleptic.
SGTC_1087 pterostilbene 9.05 µM -2.57580715321315 0.0103481775936109 no 3312 0.00500032029730017 4772 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2139 5578692 56.4705 µM -2.57710828387156 0.0103161771609731 no 3313 0.00498153670799228 4764 650991 YMR113W FOL3
SGTC_2589 lobaric acid 100 µM -2.58465262092245 0.0101323245521442 no 3314 0.00487385761545838 4722 73157 A novel microtubule depolymerizer.
SGTC_2441 5730946 39.09 µM -2.58619064637991 0.0100951962521982 no 3315 0.00485216191256831 4768 1774275
SGTC_2445 5742597 35.57 µM -2.59227064679459 0.00994958338754618 no 3316 0.00476723656343021 4761 1774255
SGTC_2878 9043973 25.97 µM -2.61146300953427 0.00950189839541831 no 3317 0.0045077870254923 4746 6465167
SGTC_1021 4476-0760 85.3 µM -2.61927730255587 0.00932472794851263 no 3318 0.00440581428028498 4781 746768
SGTC_2892 9047358 58.44 µM -2.6223328318901 0.00925624113114784 no 3319 0.00436650493538538 4772 6466771
SGTC_805 3852-0218 479 µM -2.63581494278284 0.00895928180546033 no 3320 0.00419677467800014 4773 6615355
SGTC_3091 9116372 49.47 µM -2.64967570626131 0.00866271623656098 no 3321 0.00402845326909959 4776 17169793
SGTC_2883 9059145 45.46 µM -2.67031964704292 0.00823697967540797 no 3322 0.00378895345082265 4773 16476510
SGTC_19 0279-0214 38.434 µM -2.67279844596906 0.00818711654153134 no 3323 0.00376107152702142 4797 3566274 YBR002C RER2
SGTC_1049 3226-0134 66 µM -2.68572434753208 0.00793137471269744 no 3324 0.0036186384702447 4770 5702385
SGTC_525 k781-2675 26.7 µM -2.70239075126059 0.00761201138546109 no 3325 0.00344214020072491 4749 3651118 YDL195W SEC31
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.71194563676796 0.00743407287289383 no 3326 0.00334447809698245 4739 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2362 9071156 126 µM -2.71337101996357 0.00740784486076796 no 3327 0.00333012450292801 4765 653133
SGTC_526 4469-0568 170 µM -2.71394075331691 0.00739738421483921 no 3328 0.00332440280348014 4761 2901964
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -2.72689599788758 0.00716300597354825 no 3329 0.00319665933125301 4796 4213774
SGTC_2412 st077135 33.4 µM -2.78062564172936 0.00625942915936291 no 3330 0.00271271304742318 4762 13258915
SGTC_2479 5617353 43.85 µM -2.81293566761889 0.00576603782716007 no 3331 0.00245457357851652 4771 2731746
SGTC_1297 1068-0111 14.1 µM -2.86004937274226 0.00510842097670235 no 3332 0.00211787528715745 4787 767057
SGTC_3186 9110464 49.47 µM -2.8837713680185 0.00480328984894934 no 3333 0.00196471962897874 4792 17018021
SGTC_2943 9068529 45.32 µM -2.93050865590472 0.0042492625070518 no 3334 0.00169203782794777 4759 3270634
SGTC_1111 tnp00062 510.699 nM -2.98641036654467 0.00366212531338273 no 3335 0.00141136786941698 4767 676306
SGTC_2928 9011484 9.79 µM -3.00197381336303 0.00351216760073917 no 3336 0.00134117624393963 4766 2994751
SGTC_1886 st057356 49.9 µM -3.03491513470399 0.00321281623648584 no 3337 0.00120301689200617 4796 24207747
SGTC_1887 st057648 70.8 µM -3.03903956161239 0.00317700002629232 no 3338 0.00118666842803009 4798 688672
SGTC_2881 9058953 51.95 µM -3.06445338679312 0.00296412739257821 no 3339 0.00109034076889978 4778 17122249
SGTC_293 4049-0273 38.5 µM -3.07929337735711 0.00284585317572887 no 3340 0.00103746121704546 4769 1380311
SGTC_310 1273-0058 1.06 µM -3.11999972616342 0.00254296225252875 no 3341 0.000904256040449868 4519 2734232
SGTC_1068 loratadine 26.9 µM -3.18572107877146 0.0021149801577235 no 3342 0.00072196866817547 4800 3957 A H1 histamine antagonist.
SGTC_2321 7390090 138.78 µM -3.18583051488492 0.00211432558992339 no 3343 0.00072169564027848 4794 649046
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -3.33818120291085 0.00136227949436511 no 3344 0.000421643681266831 4781 6708739 YPR165W RHO1
SGTC_235 0330-0087 5 mM -3.44708414899055 0.000984435719391991 yes 3345 0.000283336024965085 4805 46494818 YHR062C RPP1
SGTC_1248 0469-0687 58.6 µM -3.5237122001579 0.000779120739077509 yes 3346 0.000212773097643713 4794 4017482
SGTC_2951 9072950 58.06 µM -3.53672270820061 0.000748457363858011 yes 3347 0.000202562386371943 4787 16488155
SGTC_2320 7373003 200 µM -3.549784339043 0.000718795339722595 yes 3348 0.000192773427510367 4789 5415828
SGTC_237 nikkomycin 200 µM -3.77817116793066 0.000347143295767034 yes 3349 7.89921410236647e-05 4806 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2238 6671620 73.2395 µM -3.8322045271869 0.00029055035716306 yes 3350 6.35000431331064e-05 4776 729941
SGTC_255 tunicamycin 200.472 nM -3.92361211226488 0.000213938114678887 yes 3351 4.36155715227853e-05 4796 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1900 st060200 72.8 µM -3.975707902453 0.000179181833477797 yes 3352 3.50851054109811e-05 4806 688945
SGTC_2954 9074818 52.69 µM -4.16884382515822 9.12072269600285e-05 yes 3353 1.5307433329228e-05 4804 16648742
SGTC_1302 1159-0335 255 µM -4.1718493075166 9.02335595669969e-05 yes 3354 1.51068718105162e-05 4809 649284
SGTC_2165 5727197 32.143 µM -4.42053387034304 3.62494862617595e-05 yes 3355 4.92286756136009e-06 4800 1361712
SGTC_1368 1852-0141 284 µM -5.53930492136266 3.32512813213258e-07 yes 3356 1.51837252068338e-08 4775 2838987