SGTCid condition conc unit YDR327W|YDR327W.score YDR327W|YDR327W.strain.pval YDR327W|YDR327W.strain.significant YDR327W|YDR327W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1814 st052110 31.539 µM 4.54521460788047 8.01782105629585e-07 yes 1 2.74396547672406e-06 5 674163 SGTC_1948 st076329 66.6 µM 4.33590406116594 2.32931106915312e-06 yes 2 7.25811258461324e-06 2 24208413 SGTC_2581 avocatin a 64 µM 4.15403085752436 5.6691195196637e-06 yes 3 1.63334546646862e-05 5 6710728 A skin care supplement. SGTC_1688 st021091 57.6 µM 3.97612500082653 1.30879816980148e-05 yes 4 3.5023657911724e-05 2 3656366 SGTC_1959 st077091 55.8 µM 3.67982431701205 4.90137462687598e-05 yes 5 0.000116697345224748 26 821356 YKL052C ASK1 SGTC_295 k015-0027 31 µM 3.52075171016899 9.59157531127099e-05 yes 6 0.000215162675520106 3 3887424 SGTC_1982 st072467 71.9 µM 3.44307787698838 0.000131868923059096 yes 7 0.000287566835348984 11 3163533 SGTC_1136 pergolide 1.05886 µM 3.41684683003097 0.000146629721765346 yes 8 0.000316754558089841 30 47811 A dopamine receptor agonist. SGTC_20 0481-0013 4.944 µM 3.17952092766832 0.000370836021980612 yes 9 0.00073759358396777 15 182045 SGTC_2411 st077133 39.94 µM 3.11778061050353 0.000467634775927656 yes 10 0.000911091948816239 35 1403142 YNL221C POP1 SGTC_370 0180-0345 38.7 µM 3.02098551537931 0.000667454914473045 yes 11 0.00125976706238885 18 3989527 SGTC_2329 6138490 200 µM 2.95851102754324 0.000835509743769892 yes 12 0.00154564590527443 27 720019 SGTC_1834 st055981 52.8 µM 2.88275898725815 0.00109118980495093 no 13 0.00197104464622508 27 471719 YDL150W RPC53 SGTC_879 0831-1030 162 µM 2.8642459290996 0.00116373194922269 no 14 0.00209001668733774 40 1549252 SGTC_1023 4482-3888 16 µM 2.85124506871167 0.00121728633170368 no 15 0.00217741955455128 25 3303168 SGTC_3253 9135987 49.47 µM 2.83520019800562 0.00128648631794869 no 16 0.00228984884274587 13 4182430 SGTC_3127 9126946 49.47 µM 2.83221707663577 0.00129974209219994 no 17 0.00231132272083118 23 27243249 SGTC_2008 4012253 172 µM 2.79795579793254 0.00146119662401097 no 18 0.00257135749758331 26 603940 SGTC_345 1362-0200 395 µM 2.75719676730055 0.00167700265200301 no 19 0.00291496289438104 16 1419823 SGTC_1658 st012944 20 µM 2.74821483968473 0.00172830078986122 no 20 0.00299603660518159 29 24207260 SGTC_1381 2324-0066 62.1 µM 2.726571579486 0.00185782952087565 no 21 0.00319980352332226 24 10885928 SGTC_1403 3909-7815 62.9 µM 2.72073718135276 0.00189422554800784 no 22 0.00325682627667547 14 6615483 SGTC_3133 9127736 49.47 µM 2.67709557748228 0.00218768803535497 no 23 0.0037131723446875 10 27243420 SGTC_2335 9018011 154.17 µM 2.65927028460727 0.00231897464257452 no 24 0.00391550559183608 33 6458208 SGTC_1705 st027868 56.3335 µM 2.65558987270526 0.00234695435866824 no 25 0.00395849172294953 15 292948 SGTC_1805 st050013 60.3 µM 2.59394186002971 0.00286334180077912 no 26 0.00474412652142421 15 4037144 SGTC_2791 5663188 71.43 µM 2.57189017414098 0.00307160713327308 no 27 0.00505724859731944 38 54690634 SGTC_1117 retinoic acid 1.10837 µM 2.57119219094918 0.0030784164196588 no 28 0.00506745325831144 14 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3050 9093513 49.47 µM 2.54092883281271 0.00338704839272679 no 29 0.00552792104382648 27 25236664 SGTC_1818 st052136 56.3 µM 2.53962994231816 0.00340089641206637 no 30 0.00554849071833605 48 674169 SGTC_444 curcumin 90.4 µM 2.53093662000187 0.00349489676645002 no 31 0.00568792011556591 44 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2401 5128683 200 µM 2.5216598382 0.00359777366043027 no 32 0.00584012984547209 31 708373 SGTC_2627 acetyl isogambogic acid 100 µM 2.50607623834871 0.00377672226799096 no 33 0.00610396470727146 26 6857789 A caspase activator and apoptosis inducer. SGTC_1236 0330-0013 258 µM 2.50388410207976 0.00380252503642077 no 34 0.00614191326539539 10 4617066 SGTC_1004 4084-0029 199 µM 2.49548313428122 0.00390287904336871 no 35 0.00628928673838359 17 716894 YLR208W SEC13 SGTC_1121 fusaric acid 630.51 nM 2.49230998317979 0.00394139716151366 no 36 0.00634576094677025 20 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_390 dec-rvkr-cmk 16.7 µM 2.49067089847279 0.0039614266885301 no 37 0.00637510802525904 29 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_945 3381-0768 11.3 µM 2.48926974102918 0.0039786209794866 no 38 0.00640029028366373 28 1126236 YIL048W NEO1 SGTC_833 3852-0053 558 µM 2.47866747935399 0.0041109076301782 no 39 0.00659370917845946 31 3123681 SGTC_687 k029-0044 34.9 µM 2.4764502625527 0.00413906494463297 no 40 0.00663480561990855 9 5829338 SGTC_1970 st070122 35.8 µM 2.46368951535388 0.00430449871596368 no 41 0.00687575878103174 43 102928 SGTC_2634 4'-methoxyflavone 100 µM 2.44010095643489 0.00462593594381163 no 42 0.0073415789297813 29 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1079 idarubicin 2.36 µM 2.4033649576375 0.00516928509300869 no 43 0.00812248288902075 34 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2307 7538926 6.34 µM 2.39129732256838 0.0053597806199688 no 44 0.0083944753459892 61 96582 SGTC_2298 7976326 193.81 µM 2.37449439983701 0.00563541670725936 no 45 0.00878650139130554 13 2235818 SGTC_2196 6573537 42.6665 µM 2.36100743283531 0.00586568945220033 no 46 0.00911268266049662 27 2903087 SGTC_2473 5854593 8.94 µM 2.31990791055021 0.00661970824952483 no 47 0.0101729297794216 28 2872951 SGTC_634 1611-4317 11.2 µM 2.31190774744393 0.00677606469836936 no 48 0.0103913838470309 36 2843522 SGTC_3186 9110464 49.47 µM 2.30617466819114 0.00689011109572998 no 49 0.0105504372170053 22 17018021 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.30531810946565 0.0069072951117755 no 50 0.010574382019222 37 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_856 0433-0016 11.3 µM 2.30080522907954 0.00699845750834953 no 51 0.0107013213787162 25 3911780 SGTC_2027 5150920 200 µM 2.29528804506599 0.0071113489678418 no 52 0.0108583111402355 19 786715 SGTC_1522 st012842 45.6 µM 2.29287954219719 0.00716113296852997 no 53 0.0109274704643658 48 3491067 YOR116C RPO31 SGTC_780 0109-0199 192 µM 2.28468953263701 0.00733272898971097 no 54 0.0111655194150226 41 610414 SGTC_1314 1222-0010 41.1 µM 2.28404831001923 0.00734631555409198 no 55 0.0111843459545051 28 3526027 SGTC_561 1550-0330 72.9 µM 2.27129286943988 0.0076212341348993 no 56 0.0115646273032858 35 6812934 SGTC_2447 5741742 33.78 µM 2.2639466933909 0.00778364363311173 no 57 0.0117886967951999 48 1776504 SGTC_271 rotenone 740 µM 2.24814536219954 0.00814333485409356 no 58 0.0122834611713556 25 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1731 st035964 63 µM 2.24467457169873 0.00822427063550493 no 59 0.0123945158060878 58 6739575 SGTC_1319 1306-0155 43.7 µM 2.22622158669056 0.00866655225955654 no 60 0.0129996713642456 38 3122360 SGTC_2959 9079155 11 µM 2.21638675235841 0.00891068935200409 no 61 0.0133325130974333 48 16189457 SGTC_3248 9135562 49.47 µM 2.21524709008038 0.00893936596750822 no 62 0.0133715546533184 33 17650701 SGTC_3345 9148410 3.559 µM 2.21509223871991 0.00894326862909074 no 63 0.0133768670274536 22 4903596 SGTC_1501 4491-0275 38.4 µM 2.19027491685351 0.00958834337982453 no 64 0.0142521524122977 29 5104718 SGTC_343 4130-2827 29.8 µM 2.18141598866259 0.00982827102158968 no 65 0.0145763310495941 33 1118244 SGTC_3328 9140624 29.0385 µM 2.15651335703289 0.0105310099489572 no 66 0.0155218009654414 39 4904392 SGTC_1078 idebenone 36.1 µM 2.14883946222006 0.010756209096313 no 67 0.0158235640088708 50 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3235 9132602 49.47 µM 2.14857995480727 0.0107638973741838 no 68 0.0158338560412357 40 4912240 SGTC_3153 9100258 49.47 µM 2.14687023042415 0.0108146701009694 no 69 0.0159018071071445 35 25236848 SGTC_2035 5154463 94.595 µM 2.14040660492749 0.0110085052585556 no 70 0.0161609606081294 58 2769623 SGTC_339 3091-4833 71.4 µM 2.13482516595372 0.0111783095297734 no 71 0.0163876469177467 74 3240077 SGTC_655 k060-0012 42 µM 2.13049737815435 0.0113115369923553 no 72 0.0165652860196691 58 5994525 SGTC_23 0213-0011 39.996 µM 2.12630190342574 0.0114420064729062 no 73 0.016739064835673 44 627608 SGTC_1304 1165-0502 251 µM 2.10295441459924 0.0121921962599493 no 74 0.017734877249901 52 767425 SGTC_2600 tangeritin 87.95 µM 2.10231237258538 0.0122134145678544 no 75 0.0177629607347379 50 68077 A bioactive flavone. SGTC_2515 chrysin 20.77 µM 2.07650873736652 0.013093080279347 no 76 0.0189234619362263 34 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3240 9133527 49.47 µM 2.07647727498254 0.0130941854338947 no 77 0.0189249153898553 35 17617455 SGTC_506 n9-isopropylolomoucine 153 µM 2.07626129057233 0.0131017743260193 no 78 0.0189348956883993 26 6610355 SGTC_1649 st011737 51.3 µM 2.07528656330783 0.0131360699374219 no 79 0.0189799920064296 31 1761035 SGTC_564 3555-0129 330 µM 2.06349342649261 0.0135571959615108 no 80 0.0195328858550337 42 563260 SGTC_199 4063-0024 41.6 µM 2.06282951446351 0.0135812464849999 no 81 0.0195644144072355 18 306215 SGTC_2711 st079103 59.1 µM 2.05692135213864 0.0137968991156509 no 82 0.0198468958621133 32 54693780 SGTC_1597 7-benzyloxygramine 47.5 µM 2.04416851595867 0.0142724757529035 no 83 0.0204684511658518 102 260807 SGTC_2859 9028643 45.46 µM 2.04398557455325 0.0142793994390946 no 84 0.0204774861294976 29 17151580 SGTC_3330 9141424 71.43 µM 2.01719039116087 0.0153252473284212 no 85 0.0218378242220089 43 27261020 SGTC_1600 coumarin 106 71.1 µM 2.01696759842097 0.0153342118547273 no 86 0.0218494473808457 39 100336 A hepatotoxic, DNA x-linker. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.01228721634805 0.0155235803253969 no 87 0.0220948346096198 58 368090 SGTC_402 epigallocatechin gallate 10 µM 2.00912900362834 0.015652492928167 no 88 0.0222617272495794 61 65064 An antioxidant. SGTC_2175 5807670 165.306 µM 2.00858308484712 0.015674869212622 no 89 0.0222906833357859 23 241186 SGTC_635 k038-0028 24.7 µM 2.00340475622784 0.0158884883538072 no 90 0.0225669306868012 62 4035102 SGTC_16 erodoxin 22.806 µM 1.98764578256778 0.0165540086270223 no 91 0.0234254395566687 88 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1215 3852-0577 11.2 µM 1.96453881120898 0.0175729092262047 no 92 0.0247338200007933 45 2884876 SGTC_3096 9117468 49.47 µM 1.95946633965725 0.0178036086541506 no 93 0.0250290990775321 35 41316311 SGTC_2532 xanthone 78.9 µM 1.95915662205976 0.017817778127039 no 94 0.0250472237049643 35 7020 An insecticide. SGTC_776 4476-4378 112 µM 1.95219092205173 0.0181390069133714 no 95 0.0254577707846218 49 2892008 SGTC_1878 temozolomide 1 mM 1.95191022471072 0.0181520542953799 no 96 0.0254744320696468 45 5394 DNA alkylating agent. SGTC_869 0564-0080 44.1 µM 1.95068941968825 0.0182088928744695 no 97 0.0255470013660398 38 6843321 SGTC_2716 st080858 38.6235 µM 1.92710060212458 0.0193372873356361 no 98 0.026983546866859 40 5296050 SGTC_3061 glucosamine 200 µM 1.92096528760374 0.0196403311083698 no 99 0.0273680419266675 40 91431 and experimental redox chemotherapeutic SGTC_10 0279-0212 42.575 µM 1.9141861250387 0.0199798567467929 no 100 0.0277981889892293 47 39851 YBR002C RER2 SGTC_2045 5106652 78.05 µM 1.90976972923545 0.0202037144852649 no 101 0.0280814342140938 45 673349 SGTC_3216 9129716 49.47 µM 1.90436083695809 0.0204807736816553 no 102 0.028431602998853 51 8056934 SGTC_2341 7987486 176.74 µM 1.88353692482918 0.0215776790964595 no 103 0.0298138203342023 54 1258686 SGTC_835 0312-0010 67.2 µM 1.88110151499799 0.0217091497294079 no 104 0.0299790554827913 68 1626196 SGTC_2834 9001755 58.44 µM 1.87958138084527 0.0217915536105175 no 105 0.0300825763904708 58 2989575 SGTC_910 3454-3003 490 µM 1.87321974965497 0.0221392788042374 no 106 0.0305190230977937 73 820824 SGTC_2048 5246248 200 µM 1.86673918806258 0.0224983079730705 no 107 0.0309690091918033 49 677046 SGTC_916 4466-0038 42 nM 1.85276687283224 0.0232891142399283 no 108 0.0319578901578567 96 5722064 YGL116W CDC20 SGTC_466 geldanamycin 89.2 µM 1.85270085253759 0.0232929056930464 no 109 0.0319626238821689 25 5288382 HSP90 inhibitor. SGTC_2032 5185112 25.99 µM 1.84825957192856 0.0235491578915387 no 110 0.032282400598445 43 5718189 SGTC_3012 9080433 71.4286 µM 1.84565478043876 0.0237005489476236 no 111 0.0324711734883545 66 17688859 SGTC_263 alizarin 107.927 µM 1.84390353886102 0.0238027908863347 no 112 0.0325985996392723 85 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2143 5623677 140.463 µM 1.84163899108339 0.023935550456053 no 113 0.0327639868361426 52 5375313 SGTC_2118 5526350 200 µM 1.82585522779493 0.0248782656245958 no 114 0.0339360358747391 64 743594 SGTC_863 0466-0191 129 µM 1.82035207954489 0.0252141883866703 no 115 0.0343527025446959 78 765160 YPR165W RHO1 SGTC_598 3937-0236 20.2 µM 1.81648810706066 0.025452317195186 no 116 0.0346477653279054 63 1379313 SGTC_38 0929-0051 58.268 µM 1.80896244444582 0.0259215168883821 no 117 0.0352284190288332 60 1379719 SGTC_1124 fisetin 1.16336 µM 1.80569935089629 0.0261271973790321 no 118 0.0354826570581422 67 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3071 9117417 49.47 µM 1.8018917090717 0.0263689256937506 no 119 0.0357812224580611 66 45595590 YGL055W OLE1 SGTC_1694 st024011 44.9 µM 1.79686536606754 0.026690883128252 no 120 0.0361784980489352 59 2787533 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.79358759675622 0.0269026009757562 no 121 0.0364395088484929 71 688662 SGTC_3162 9099653 49.47 µM 1.79200361155099 0.027005415220083 no 122 0.0365661937472598 48 25237511 SGTC_2986 9022445 71.43 µM 1.79010521572571 0.0271290692625997 no 123 0.0367184992435879 67 6459286 SGTC_540 1187-0821 17.3 µM 1.77836569758002 0.0279042717980027 no 124 0.0376719063260593 81 847520 SGTC_670 4204-0025 119 µM 1.77412132985365 0.0281890462777208 no 125 0.0380215416628802 54 719039 SGTC_1007 4101-0031 70 µM 1.77219228051617 0.0283192726475978 no 126 0.0381813223006574 78 1146276 SGTC_1913 st060213 96.1 µM 1.77112270763356 0.0283916929432202 no 127 0.038270149340219 63 688959 SGTC_1336 1486-0901 104 µM 1.7670023581145 0.0286721217726798 no 128 0.038613916691476 51 5006114 SGTC_1644 st010134 20.9 µM 1.76361032055133 0.0289047072794965 no 129 0.0388988044623863 58 3818134 SGTC_474 dl-dihydrosphingosine 5 µM 1.75677883629306 0.0293778899445751 no 130 0.0394777568913624 72 3058739 A sphingolipid protein kinase C inhibitor. SGTC_900 1112-0045 141 µM 1.74413537485244 0.0302706068611394 no 131 0.0405677434614607 56 56211 YIL048W NEO1 SGTC_2069 5228469 200 µM 1.74328384646583 0.0303315302062697 no 132 0.0406420227948398 73 2835210 SGTC_817 1391-0715 46 µM 1.74241850152202 0.0303935461280213 no 133 0.0407176204018548 97 1353946 SGTC_266 formosanin C 406 nM 1.74150369304358 0.0304592211115222 no 134 0.0407976632454045 101 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_336 4111-0029 111 µM 1.73563766350511 0.0308831483992078 no 135 0.0413139610037669 58 3131175 SGTC_2688 kanamycin b 96.69 µM 1.73426111014442 0.0309833337183701 no 136 0.0414358822151032 112 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1733 st037357 54.9 µM 1.73127033715916 0.0312019287851869 no 137 0.0417017797009785 81 1272339 YGL099W LSG1 SGTC_535 2293-4129 48.2 µM 1.72857475937207 0.0314000396234718 no 138 0.0419426151488049 88 396118 YIL048W NEO1 SGTC_3215 9129942 49.47 µM 1.71953685598706 0.0320718812346166 no 139 0.0427583313205689 81 17682944 SGTC_1180 1193-0155 285 µM 1.71574953718434 0.0323569227131113 no 140 0.04310394691712 73 2921347 SGTC_1758 st042942 75.2445 µM 1.69908278757509 0.033636244591043 no 141 0.0446517930169812 78 669317 SGTC_2932 9016711 44.54 µM 1.69843617100812 0.0336867052793833 no 142 0.0447127350480525 75 7117328 SGTC_2396 5342950 42.78 µM 1.69652979109082 0.0338358381016974 no 143 0.0448927966287904 126 1886677 SGTC_3338 9144300 39.5675 µM 1.6871880498218 0.0345744980287135 no 144 0.04578359925236 52 4901274 SGTC_1162 k048-0130 20.1 µM 1.6846981959645 0.0347735933254705 no 145 0.0460234073791233 70 6797406 SGTC_2524 avocatin b 10.57 µM 1.68342054063788 0.0348761229202676 no 146 0.0461468548236105 42 6710748 SGTC_3166 9102297 49.47 µM 1.68301098777811 0.0349090412956399 no 147 0.0461864821842056 71 25237072 SGTC_1677 st019204 53.9 µM 1.66992768554465 0.0359741233653044 no 148 0.0474668359764566 71 3945625 SGTC_1020 4335-0961 93.3 µM 1.66296505390478 0.0365516994112795 no 149 0.0481597154718404 84 669075 SGTC_770 0389-1121 67.2 µM 1.65827639563863 0.0369448991633101 no 150 0.0486308455439765 80 6753108 SGTC_1364 1653-0028 37.6 µM 1.65768010376313 0.0369951522629835 no 151 0.0486910258902796 63 5718652 SGTC_2999 9069765 71.4286 µM 1.65565523490201 0.0371662173147785 no 152 0.0488958287996602 60 2097066 SGTC_3142 9086498 49.47 µM 1.65293471196237 0.0373970697108055 no 153 0.0491720758211497 122 25236367 SGTC_1875 nocodazole 6 µM 1.65017201071211 0.0376326984243728 no 154 0.0494538798672713 78 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2311 7694451 200 µM 1.64919858287514 0.0377160095735915 no 155 0.0495534790979236 114 2163142 SGTC_532 1548-0774 215 µM 1.64839264910243 0.0377850995536626 no 156 0.049636061746511 88 5932993 SGTC_2331 7980721 200 µM 1.64211613180261 0.0383267058799051 no 157 0.0502829695587448 103 2981221 SGTC_1700 st030840 7.9285 µM 1.64000599271308 0.0385102071094086 no 158 0.0505019604681498 105 5499307 SGTC_1841 st054148 70 µM 1.63963107982304 0.0385428849530849 no 159 0.0505409484237041 81 675442 SGTC_1430 4049-0248 69.1 µM 1.6378975902318 0.038694271838488 no 160 0.0507215293758531 75 22774488 SGTC_487 nimodipine 119 µM 1.63778741295124 0.0387039100494466 no 161 0.0507330240998538 40 4497 L-type voltage-gated calcium channels inhibitor SGTC_545 4218-0007 221 µM 1.63608561446731 0.0388530304467107 no 162 0.0509108352436377 83 2840508 SGTC_887 0885-0007 9.62 µM 1.63342353087451 0.0390872342010673 no 163 0.0511899757061254 98 5719458 SGTC_1830 st055982 50.3 µM 1.63212567586914 0.0392018324267208 no 164 0.0513265069274119 76 455313 An antimicrobial agent. SGTC_861 0443-0273 110 µM 1.63147386470636 0.0392594892324488 no 165 0.0513951850804522 89 6149169 SGTC_1368 1852-0141 284 µM 1.62811096474171 0.0395580563631283 no 166 0.0517506795012325 81 2838987 SGTC_286 k060-0067 22.9 µM 1.62007237475832 0.0402792306409898 no 167 0.0526083654212222 92 5985051 SGTC_480 am 92016 50 µM 1.61681395617496 0.0405745816850733 no 168 0.0529592229719783 98 2129 K+ channel blocker. SGTC_1148 3909-7663 27.7 µM 1.6143965150085 0.0407948384446165 no 169 0.0532207235805536 65 4084526 SGTC_2351 9026858 72.31 µM 1.61019814474796 0.0411796631043776 no 170 0.053677303154195 100 1409300 SGTC_1972 st070201 17.4 µM 1.60627101694412 0.0415422846425929 no 171 0.0541071877761554 75 2829099 SGTC_2518 prenyletin 46.28 µM 1.60558990629698 0.0416054392459992 no 172 0.0541820223461507 42 3873459 A coumarin with calcium channel inhibitory activity. SGTC_956 1185-0240 191 µM 1.59914777113882 0.0422066278124253 no 173 0.054893886102939 72 1416193 SGTC_1715 st032160 10.2275 µM 1.59449132354548 0.0426455352354471 no 174 0.0554130162677462 74 5289825 SGTC_350 k064-0020 19.8 µM 1.58818060154755 0.0432462528978631 no 175 0.0561227531456966 88 2790705 SGTC_196 k015-0023 18.111 µM 1.5827785111643 0.0437658898565402 no 176 0.0567359781121899 59 5211998 SGTC_1367 1812-0510 76.9 µM 1.5824897133563 0.0437938110832638 no 177 0.0567689093907533 80 1142582 YDR527W RBA50 SGTC_2915 7971052 15.16 µM 1.57744675752701 0.0442836888317337 no 178 0.0573463819374356 60 5741558 SGTC_2807 7945238 51.95 µM 1.57185085611026 0.0448324397269712 no 179 0.0579925720056097 89 17148797 SGTC_1828 st055811 49 µM 1.56402487943692 0.0456090467957732 no 180 0.0589058628894322 52 5877589 SGTC_2504 purpurogallin 52.29 µM 1.55717105792947 0.0462980329170656 no 181 0.0597149389466206 81 5281571 An antioxidant. SGTC_1479 0549-0158 134 µM 1.55635609883647 0.0463805103670707 no 182 0.0598117192025729 87 5440202 SGTC_822 1487-0950 154 µM 1.55623287661856 0.046392991257777 no 183 0.0598263631129691 67 1958375 SGTC_249 wiskostatin 11.211 µM 1.55389733096282 0.0466300634836637 no 184 0.0601044542466493 82 2775510 A n-wasp and actin depolymerizer. SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.55220700487506 0.0468022475744264 no 185 0.0603063502757336 56 6708630 An antioxidant. SGTC_2640 pentamidine 10.38 µM 1.55219870422847 0.0468030943717038 no 186 0.0603073430301407 103 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_371 0195-0006 7.36 µM 1.5519709133418 0.0468263374428764 no 187 0.0603345917321534 94 3928593 SGTC_1596 piperlongumine 63 µM 1.54783233857675 0.0472502391349478 no 188 0.0608313341860187 76 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_979 1426-2828 121 µM 1.54405970743301 0.047639332936011 no 189 0.0612869343954148 95 747872 SGTC_2398 5228213 48.84 µM 1.54147397339798 0.04790749411718 no 190 0.0616007362641182 119 80771 YMR134W ERG29 SGTC_1637 st007924 17.4 µM 1.5382441198681 0.0482441514811037 no 191 0.0619944685454933 73 683336 SGTC_797 k781-0471 270 µM 1.5354343714338 0.0485385570308451 no 192 0.0623385831362099 96 23738129 SGTC_1708 st033234 31.827 µM 1.52949044555841 0.0491660952564055 no 193 0.0630714529296192 96 674664 SGTC_289 k017-0060 526 µM 1.51810852024362 0.0503858302048856 no 194 0.0644935218094386 85 5512909 SGTC_1988 st071872 53.4 µM 1.51431372122508 0.0507978153183013 no 195 0.0649731450564889 66 16414116 SGTC_1248 0469-0687 58.6 µM 1.51319008764042 0.0509203167644017 no 196 0.0651156906788877 98 4017482 SGTC_3343 9148379 18.9835 µM 1.50596433005306 0.0517137159008183 no 197 0.0660381653677326 79 1955036 SGTC_2794 7785382 27.27 µM 1.50262813947038 0.0520833355853632 no 198 0.0664674814183726 107 2205081 SGTC_746 1095-0025 46.6 µM 1.49803988384669 0.0525950970190474 no 199 0.0670614442137017 98 6749286 SGTC_1096 rimcazole 32.2 µM 1.49440478359077 0.0530033727909501 no 200 0.0675349260176888 81 18528119 A dopamine reuptake inhibitor. SGTC_2189 6047310 154.431 µM 1.49418227454515 0.0530284452682843 no 201 0.0675639921206662 84 711535 SGTC_2828 7998861 71.43 µM 1.49082915815841 0.0534074167223646 no 202 0.0680031771670861 61 2988188 SGTC_1958 st076513 41.9 µM 1.49060813749544 0.053432471830423 no 203 0.0680322033017812 99 732122 YGL099W LSG1 SGTC_2630 antimycin a 100 µM 1.48972177172288 0.0535330446681678 no 204 0.0681487037839793 105 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3014 9081533 49.47 µM 1.48743035185076 0.0537937392056743 no 205 0.0684505927606402 114 21367265 SGTC_844 0330-0132 15.3 µM 1.48554184261084 0.0540093495107841 no 206 0.0687001739380903 88 2828079 SGTC_1299 1079-1439 3.74 µM 1.48315849377267 0.0542824312392742 no 207 0.069016152981546 104 323161 SGTC_766 1391-0721 126 µM 1.47030454115976 0.0557741056293061 no 208 0.0707396458485736 109 1020919 YIL115C NUP159 SGTC_2663 amphotericin b 100 µM 1.46239634642332 0.0567077876501907 no 209 0.0718163150277795 124 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_893 0958-0369 48.9 µM 1.4598018820242 0.0570167715782453 no 210 0.0721722655901007 109 6819948 SGTC_1886 st057356 49.9 µM 1.45233191219918 0.0579138020752016 no 211 0.0732046691389423 97 24207747 SGTC_1158 4092-0494 91.8 µM 1.44814851287741 0.0584209895592571 no 212 0.0737877601976872 82 1148199 SGTC_1273 0849-0096 14.1 µM 1.44729167562521 0.0585253000233024 no 213 0.0739076247963381 118 5286025 SGTC_257 daunorubicin 18.5 µM 1.44706286984746 0.0585531793220412 no 214 0.0739396580311407 106 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1275 0867-0008 21.1 µM 1.44485294755946 0.0588229887359816 no 215 0.0742495975512362 91 3422836 SGTC_1088 bifonazole 369 nM 1.44443737872273 0.0588738343505377 no 216 0.0743079913631322 82 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2506 ethyl hematommate 54.16 µM 1.44189956880589 0.0591850888260188 no 217 0.0746653539393789 75 3940691 An allergen. SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.43902126754461 0.0595396637461117 no 218 0.0750722485821492 89 140250 A respiratory chain inhibitor. SGTC_1803 st050068 52.4 µM 1.43706487090254 0.0597816190951892 no 219 0.075349780879961 109 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_293 4049-0273 38.5 µM 1.43457944226045 0.0600901120452147 no 220 0.0757034881049233 103 1380311 SGTC_84 0443-0269 128.823 µM 1.43184832852505 0.0604305354473941 no 221 0.0760936163585167 106 6150058 SGTC_490 phenamil 164 µM 1.43123995785181 0.0605065717752892 no 222 0.0761807276507456 99 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_732 3970-1727 52.7 µM 1.42960919669061 0.0607107593654578 no 223 0.0764146072621868 111 1275699 SGTC_3125 9127534 49.47 µM 1.42176448787963 0.0617005361594581 no 224 0.0775473160211942 81 1639235 SGTC_109 0132-0036 33.701 µM 1.42149533555 0.0617347176718059 no 225 0.0775864043203322 98 67274 A color developer. SGTC_1270 0831-1170 17.3 µM 1.42143011448569 0.0617430027697804 no 226 0.0775958784587689 113 6764716 SGTC_1750 st081859 2.357 µM 1.42055836524259 0.0618538253187806 no 227 0.0777225947932485 144 5291695 SGTC_2905 7799065 20.05 µM 1.41865772687397 0.062095985308234 no 228 0.0779994136123749 111 1296806 SGTC_2570 licareol 100 µM 1.41734633921296 0.0622634997659842 no 229 0.0781908465965196 108 443158 SGTC_567 1080-0542 68.4 µM 1.41714823609187 0.0622888357412572 no 230 0.0782197961343642 95 5950415 SGTC_1286 0929-0070 131 µM 1.41468971496379 0.062603932545192 no 231 0.0785797456286409 106 1420408 SGTC_665 3914-0008 307 µM 1.41403210292159 0.0626884257792076 no 232 0.0786762384147662 99 1069549 SGTC_41 0478-0632 82.643 µM 1.41281502679248 0.0628450361430789 no 233 0.0788550593757452 123 3750424 SGTC_1369 1866-0067 208 µM 1.41276427969777 0.0628515727688347 no 234 0.0788625221597373 105 3531355 SGTC_1977 st070720 65.3 µM 1.41042275458385 0.0631537561682617 no 235 0.0792074451994574 85 682188 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.40769410647231 0.063507325458375 no 236 0.0796108338580082 133 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_834 0312-0008 75.7 µM 1.40710048766031 0.0635844482809893 no 237 0.0796987967714977 110 6385573 YIL048W NEO1 SGTC_2309 7664088 163.95 µM 1.40663888020333 0.0636444705724022 no 238 0.0797672489372677 112 704922 SGTC_421 streptovitacin 30 mM 1.40552492878744 0.0637894979584967 no 239 0.0799326208846436 106 91467 include heat shock SGTC_1507 4075-3230 155 µM 1.40204258760971 0.0642445285984447 no 240 0.0804512648446096 88 659771 SGTC_1058 3448-5425 97.3 µM 1.40138302741633 0.064330995494887 no 241 0.0805497824558135 128 7279705 SGTC_3305 9127027 53.8275 µM 1.40133786945049 0.064336918911618 no 242 0.0805565309716766 108 41905295 SGTC_1399 3562-5772 25 µM 1.39998473341033 0.0645146078550972 no 243 0.0807589450859798 101 23847490 SGTC_2568 diosmetin 100 µM 1.39307841757534 0.0654274651498385 no 244 0.0817980393836101 129 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3329 9141233 27.5565 µM 1.39118618910827 0.0656793148944635 no 245 0.0820844870712426 112 4909101 YNL103W MET4 SGTC_2119 5528445 120.635 µM 1.39043259948534 0.0657798243485531 no 246 0.0821987764973415 108 791935 SGTC_588 3970-1144 52.9 µM 1.38921504109093 0.0659424671613657 no 247 0.0823836846472814 76 1888707 SGTC_1012 4112-3522 18 µM 1.38787717589171 0.0661215398317567 no 248 0.082587224510948 105 3112398 SGTC_1939 st074455 53.6 µM 1.38781299314979 0.0661301401238774 no 249 0.0825969986383616 108 1644229 SGTC_1692 fluoroquinolonic acid 71 µM 1.38424614770779 0.066609450093351 no 250 0.083141548670454 100 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2257 7960413 200 µM 1.37769342174105 0.067497002401027 no 251 0.0841489816163409 127 2974689 YIL048W NEO1 SGTC_2412 st077135 33.4 µM 1.37752946301628 0.0675193268814649 no 252 0.0841743060463437 107 13258915 SGTC_2022 5136654 200 µM 1.37496197067861 0.0678696591680717 no 253 0.0845716175167258 129 1713771 SGTC_194 1486-1323 56.904 µM 1.37461280623031 0.0679174106187023 no 254 0.0846257581130921 131 5178754 SGTC_843 0310-0051 143 µM 1.3732090751579 0.0681096456033768 no 255 0.084843679617312 115 2065037 SGTC_779 1360-0071 233 µM 1.3713461122613 0.0683654187135174 no 256 0.0851335437055483 120 7566 SGTC_1924 st058459 75.1 µM 1.37073624781067 0.068449310100999 no 257 0.0852285954329276 98 688683 SGTC_3047 9092122 49.47 µM 1.36942814896957 0.0686295166598772 no 258 0.0854327401234923 107 17173831 SGTC_3094 9117742 49.47 µM 1.36544874137356 0.0691799786022446 no 259 0.0860560266530402 136 17149698 SGTC_2686 alizarin 95.37 µM 1.36025719251847 0.0699032195247553 no 260 0.0868742748314354 101 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2855 9016525 58.44 µM 1.35716420950337 0.0703368643325584 no 261 0.0873645200445233 123 43811474 SGTC_2741 miltefosine 3.04 µM 1.35537820765408 0.0705882071531502 no 262 0.08764854456656 78 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2252 omeprazole 400 µM 1.35032482754331 0.07130310603664 no 263 0.0884559059371372 83 4594 A proton pump inhibitor. SGTC_458 nppb 133 µM 1.34961086355824 0.0714045566464284 no 264 0.0885704188293325 105 4549 A chloride channel blocker. SGTC_3086 9117350 49.47 µM 1.3484040980141 0.0715762836512598 no 265 0.0887642233218474 74 2679265 SGTC_1451 4152-0210 104 µM 1.34785814627633 0.071654078547814 no 266 0.0888520059211325 111 659563 SGTC_1010 4112-3296 15.2 µM 1.34705742817846 0.0717682934589063 no 267 0.0889808688395966 91 704384 SGTC_3223 9129970 49.47 µM 1.34523403159181 0.0720289048531364 no 268 0.0892748347217289 130 17248386 SGTC_386 1509-0011 3.07 µM 1.3420048449849 0.0724922200661459 no 269 0.0897972123641521 108 3107280 SGTC_977 1348-1378 135 µM 1.34170560973138 0.0725352688694808 no 270 0.0898457337093983 127 X977 SGTC_1827 berberine 7.24 µM 1.34154975879271 0.0725576977664688 no 271 0.0898710128374004 93 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1686 st019653 115.5 µM 1.33495698537921 0.0735113535239662 no 272 0.0909452125887613 128 97252 SGTC_2179 6298986 200 µM 1.33214283821221 0.0739213315986972 no 273 0.0914066279207516 121 738374 SGTC_2543 pimpinellin 60.67 µM 1.32422302527608 0.0750845046713397 no 274 0.0927144930034696 116 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1116 jasmonic acid  1.58368 µM 1.32319550858681 0.0752364320524308 no 275 0.0928851846303692 117 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_873 0591-4978 488 µM 1.31999409738841 0.0757112916458878 no 276 0.0934184943618275 133 3305145 SGTC_799 1310-0557 151 µM 1.31732609692249 0.0761087726889227 no 277 0.0938646706066355 127 5354492 SGTC_2525 harmine 47.85 µM 1.31531384322562 0.0764096093610225 no 278 0.0942022237884871 108 5280953 A monoamine oxidase inhibitor SGTC_3069 9117009 49.47 µM 1.31469852666705 0.0765017810259773 no 279 0.0943056209706451 96 41904981 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.31153997406557 0.0769762499509129 no 280 0.0948376988397722 117 75037 A free radical scavenger. SGTC_2057 5236571 38.335 µM 1.30236851385609 0.0783666378236853 no 281 0.0963952203183526 118 54684039 YBR257W POP4 SGTC_1283 0922-0125 16.4 µM 1.30235716563947 0.078368369924411 no 282 0.0963971590764063 114 3360884 SGTC_297 0986-0032 24 µM 1.29848754040976 0.0789606926440752 no 283 0.0970599275317023 138 2847425 SGTC_49 0717-0965 32.132 µM 1.2912039485204 0.0800847798072448 no 284 0.0983164831523818 128 5889349 YGL099W LSG1 SGTC_2053 5265679 138 µM 1.28889281032899 0.0804439776774346 no 285 0.0987176769553446 140 764595 SGTC_570 0987-0065 62.6 µM 1.28713002032437 0.0807187683445924 no 286 0.0990244867247478 111 3104428 SGTC_3095 9117207 49.47 µM 1.28679561850441 0.0807709761138213 no 287 0.0990827672587647 82 17015229 SGTC_1907 st060210 83.7 µM 1.28633453382062 0.080843003784356 no 288 0.0991631675940971 142 688793 SGTC_3303 9125618 40.5795 µM 1.28164970288912 0.0815775894310128 no 289 0.0999827781427661 123 22695467 SGTC_1954 st077032 68.9 µM 1.28075641439396 0.0817182274110568 no 290 0.100139618811464 128 698907 SGTC_2700 st077718 96.8 µM 1.27627088201884 0.0824271870804532 no 291 0.100929889786621 124 904970 SGTC_2505 galangin 7.89 µM 1.27502036820591 0.0826256598263795 no 292 0.101151016394412 142 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1115 galangin 695.678 nM 1.27461839681231 0.0826895342273464 no 293 0.10122217136394 136 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1291 0993-0025 5.79 µM 1.27234618979935 0.0830512932911295 no 294 0.101625071977645 124 4353356 SGTC_2083 5306046 65.942 µM 1.27160126770785 0.0831701513727705 no 295 0.10175741305846 129 539837 SGTC_2104 5389443 200 µM 1.2671176683892 0.0838882474557506 no 296 0.102556609417384 134 2244536 SGTC_1258 0671-0043 57.1 µM 1.26469707008648 0.0842778624410967 no 297 0.10298997033174 149 4298767 SGTC_3336 9143619 71.43 µM 1.26392061503671 0.084403126436819 no 298 0.103129260849775 108 45595730 SGTC_1754 st042065 16.137 µM 1.2631853906563 0.0845218674877089 no 299 0.103261280940943 150 1126236 YIL048W NEO1 SGTC_1001 4048-4355 44.4 µM 1.26229100891443 0.0846664818441121 no 300 0.103422045398043 153 21824233 SGTC_1909 st060837 51.5 µM 1.26123559478538 0.0848373724488189 no 301 0.103611988903375 132 678937 SGTC_3251 9135047 49.47 µM 1.25969232224643 0.0850877215108085 no 302 0.103890188073341 107 17682963 SGTC_1553 gossypol 38.6 µM 1.25895676056047 0.0852072386893124 no 303 0.104022975125788 112 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2131 toluylene red 5.2905 µM 1.25743585048697 0.085454761468496 no 304 0.104297927175729 117 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2096 5468907 200 µM 1.25675817472423 0.0855652241001501 no 305 0.104420607744549 125 759785 SGTC_2619 obliquin 87.91 µM 1.25631185667985 0.0856380332947845 no 306 0.104501462398782 138 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2046 4110841 106 µM 1.2556036171207 0.0857536657211771 no 307 0.104629859646687 152 44119630 YMR134W ERG29 SGTC_1821 st053465 65.6 µM 1.25175649295911 0.0863838180956021 no 308 0.105329303942261 110 675086 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.25031389345962 0.0866210039494746 no 309 0.105592452560673 127 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_868 0527-0199 213 µM 1.24958632345188 0.0867408123078651 no 310 0.105725350846493 139 2849450 SGTC_2285 7945142 200 µM 1.2485373288565 0.0869137673091063 no 311 0.105917173492403 127 2970608 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.2484445858818 0.0869290708723625 no 312 0.105934144875627 135 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1306 1185-0270 9.02 µM 1.24395727972168 0.0876719305858063 no 313 0.106757643092789 142 1548076 SGTC_2625 euphol 100 µM 1.24245387242531 0.0879218712952203 no 314 0.107034574765808 149 6708538 A triterpene alcohol. SGTC_1118 chelidonine 707.474 nM 1.24236772826546 0.0879362087985264 no 315 0.107050458432652 119 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2927 9011802 47.9 µM 1.23992965974903 0.0883427148811353 no 316 0.107500706176663 118 43912568 SGTC_2820 7989630 71.43 µM 1.23662554852481 0.088895851402126 no 317 0.108113065227299 90 2984098 SGTC_1214 0358-0031 63.7 µM 1.2292966473779 0.0901319679726976 no 318 0.109480301918742 140 4301366 SGTC_3244 9134489 49.47 µM 1.22744003194698 0.0904471285002759 no 319 0.109828624009286 142 16584271 SGTC_1169 aniline yellow 25.8 µM 1.22433958090595 0.0909752531080783 no 320 0.11041207568856 140 6051 A DNA damaging agent. SGTC_1556 plumbagin 1.48 µM 1.22139526062461 0.0914788971306364 no 321 0.110968200386795 150 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_207 4185-0010 4.486 µM 1.21749113071546 0.0921499053286839 no 322 0.111708704468115 138 3761753 SGTC_1901 st060216 58.6 µM 1.21608669112958 0.0923921772992886 no 323 0.111975949914335 122 688792 SGTC_1086 cerivastatin 2.18 µM 1.21539974064032 0.0925108507777117 no 324 0.112106833453568 136 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1176 0848-0131 83.3 µM 1.20552582719356 0.0942290876328702 no 325 0.114000186877085 141 6769040 SGTC_1377 2944-0135 198 µM 1.20423064923735 0.0944562067624267 no 326 0.114250221424136 125 1894137 SGTC_936 3005-4620 401 µM 1.2026745938732 0.0947296061548625 no 327 0.114551134575981 147 777207 SGTC_2970 9090938 41.86 µM 1.1996635412297 0.095260304360756 no 328 0.115135019013161 146 17217104 SGTC_337 1315-0038 354 µM 1.19805112337502 0.095545391541467 no 329 0.115448557515526 115 1626437 SGTC_753 1322-0200 289 µM 1.19711161095001 0.0957117934065661 no 330 0.115631527470917 123 5403907 SGTC_1309 pyrazolanthrone 13.4 µM 1.19514388145121 0.0960609988147264 no 331 0.116015409911744 163 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_247 mechlorethamine 29.705 µM 1.19506446175607 0.0960751127656837 no 332 0.116030922795111 121 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2837 9008476 45.46 µM 1.19268144977473 0.096499315651344 no 333 0.116497076656882 127 2992805 SGTC_226 1,3-diallylurea 8.28947 mM 1.19191610496843 0.0966358471430298 no 334 0.116647071325256 130 74537 YKL182W FAS1 SGTC_1885 st057546 99.9 µM 1.19182997605979 0.0966512207406436 no 335 0.116663959706856 134 702008 SGTC_2918 7977171 22.06 µM 1.19157448144584 0.0966968358738312 no 336 0.116714067958397 146 2236483 SGTC_2084 5306078 60.6385 µM 1.19155540679618 0.0967002420306332 no 337 0.116717809539097 145 679340 SGTC_3105 9121040 49.47 µM 1.18902788879471 0.097152360283617 no 338 0.117214346313215 112 41448907 SGTC_2094 5332512 191.667 µM 1.1881932589484 0.0973019976811169 no 339 0.117378639451254 144 755774 SGTC_1483 3453-0561 55.9 µM 1.18790736171484 0.0973532938980912 no 340 0.11743495451837 152 4546991 SGTC_992 3909-8734 162 µM 1.18668707283311 0.0975724634754863 no 341 0.11767553797663 135 4288319 SGTC_2488 5268135 45.7 µM 1.18599994911535 0.0976960332257038 no 342 0.117811159809495 164 1270356 YLR208W SEC13 SGTC_740 k014-0057 261 µM 1.18488275671517 0.0978971897837223 no 343 0.118031902983851 158 4012779 SGTC_495 decylubiquinone 155 µM 1.17622303368085 0.0994667242791887 no 344 0.119752881214087 142 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_217 ketoconazole 989 nM 1.17467619202342 0.0997490075131859 no 345 0.120062143920852 149 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1640 st009078 66.4 µM 1.17253064814962 0.100141516191775 no 346 0.120492037375801 155 690618 SGTC_2949 9072542 2.23 µM 1.17071211031068 0.100475083848722 no 347 0.120857257868947 142 16457352 SGTC_415 dibenzyl ketone 100 µM 1.16972237928608 0.1006569668604 no 348 0.121056354540954 158 7593 SGTC_939 1165-0479 45.3 µM 1.16878892151433 0.100828728479057 no 349 0.12124434248204 135 1377347 SGTC_416 estradiol valerate 100 µM 1.16627080261073 0.101293142590529 no 350 0.121752487059439 162 13791 A steroid. SGTC_2278 7948257 134.34 µM 1.16345811167393 0.101813724752303 no 351 0.122321841930977 137 1247028 SGTC_3183 9108214 49.47 µM 1.16305565626783 0.101888371513712 no 352 0.122403460963671 88 4974831 SGTC_1560 lithocholic acid 53.1 µM 1.16139895061389 0.102196074018386 no 353 0.122739847773716 126 9903 A bile acid which acts as a detergent. SGTC_2616 abietic acid 100 µM 1.16112960304526 0.102246164175716 no 354 0.122794598833746 161 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3103 9120822 49.47 µM 1.16077966468078 0.102311268349304 no 355 0.122865757397206 181 17141819 SGTC_450 aminopyrene 156 nM 1.1604939882215 0.102364439285522 no 356 0.122923869994178 161 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1041 0206-0046 107 µM 1.16014900406009 0.102428675526722 no 357 0.122994072709378 146 50494 SGTC_2382 9035899 200 µM 1.15950061969037 0.102549484357194 no 358 0.123126092040449 169 6462679 SGTC_2262 9014885 67.46 µM 1.14945800118872 0.104433897278934 no 359 0.125183587637185 140 6457424 SGTC_805 3852-0218 479 µM 1.14693833683867 0.104910603874738 no 360 0.12570355342178 147 6615355 SGTC_3001 9076041 71.4286 µM 1.14684283331643 0.104928703551168 no 361 0.125723291419354 135 16004211 SGTC_542 3381-0244 89.3 µM 1.1460070276037 0.105087200597924 no 362 0.12589612213625 159 1112843 SGTC_2295 7971645 200 µM 1.14288584690082 0.105680613720293 no 363 0.126542994763408 135 2978226 YKL099C UTP11 SGTC_2288 7946289 167.31 µM 1.14140516824464 0.10596297284872 no 364 0.126850677485054 149 1246052 SGTC_473 2-arachidonoylglycerol 10 µM 1.1397403389028 0.10628109935413 no 365 0.127197247997903 163 5282280 An endocannabinoid. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.136484318601 0.106905273689993 no 366 0.127876962406853 156 165521 SGTC_3004 9076122 71.4286 µM 1.13554063791987 0.107086669224194 no 367 0.128074432500755 151 44782551 SGTC_2255 7941087 197.44 µM 1.13324431589593 0.107528998285962 no 368 0.128555834359238 145 935561 SGTC_180 1486-1293 102.781 µM 1.13307160487046 0.107562319910477 no 369 0.128592092278158 152 4140536 SGTC_1260 0700-1617 7.75 µM 1.13153167674261 0.107859751563743 no 370 0.128915689310984 152 2853078 SGTC_2983 9022671 12.99 µM 1.13124203904376 0.107915760178649 no 371 0.12897661617439 146 6405161 SGTC_857 0438-0306 1.35 µM 1.13030532576594 0.108097040262369 no 372 0.129173795609399 144 4686136 SGTC_2241 6772625 37.8075 µM 1.12823458907198 0.108498563206158 no 373 0.129610429869541 162 2285411 SGTC_2156 5649887 115 µM 1.12570263627243 0.108990974178427 no 374 0.130145703756146 164 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_759 3486-0358 89.3 µM 1.12248440674264 0.109619167083471 no 375 0.130828266946827 169 875103 SGTC_1530 rhein 70.4 µM 1.12012482718591 0.110081401878789 no 376 0.13133028607992 155 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2186 6124449 200 µM 1.11958104823688 0.110188124569272 no 377 0.131446167680995 159 3834182 YLR033W RSC58 SGTC_225 nsc-122657 1.016 µM 1.11580728902715 0.110930811986694 no 378 0.132252316535838 143 275685 SGTC_2549 cedrol 20.94 µM 1.11294057505735 0.111497381848584 no 379 0.132866976132941 172 6708665 A sedative which affects the nervous system. SGTC_1859 st055998 20 µM 1.11227744552047 0.111628735430928 no 380 0.133009439147246 151 676301 SGTC_2067 5224629 34.075 µM 1.11192696096262 0.111698204583365 no 381 0.133084777735276 158 2835000 SGTC_3031 9088762 49.47 µM 1.11166641859641 0.111749866431017 no 382 0.133140801782313 155 205253 SGTC_2193 5925765 200 µM 1.11097173897453 0.111887695056668 no 383 0.133290257057832 145 877370 SGTC_1434 4073-0095 163 µM 1.10802537437115 0.112473622715004 no 384 0.133925428771941 169 24133745 SGTC_3204 9114183 49.47 µM 1.10533422456084 0.113010709642006 no 385 0.134507396656704 152 17027248 SGTC_2178 5812956 200 µM 1.10161799681183 0.113755382119703 no 386 0.135313890461082 158 5403383 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.10086059169969 0.113907582034674 no 387 0.135478667906092 177 7104 SGTC_2605 digitonin 300 nM 1.10006685369969 0.114067238665299 no 388 0.13565149725788 187 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1404 3909-7820 48.3 µM 1.0991966612871 0.114242456849475 no 389 0.135841147363194 159 23741373 SGTC_373 0844-0104 25.9 µM 1.09897033758748 0.114288059803561 no 390 0.135890502185207 176 5375804 SGTC_2967 9089538 49.85 µM 1.09593376353499 0.114901166400598 no 391 0.136553881036128 185 728216 SGTC_420 mitomycin C 81.9 mM 1.09377698566157 0.115338054290706 no 392 0.13702640006617 161 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1407 3909-7909 12.3 µM 1.09321774424008 0.115451529588228 no 393 0.137149104009198 154 4411780 SGTC_1402 3909-7673 35.9 µM 1.09273461539505 0.11554962478836 no 394 0.137255168401247 154 5328014 SGTC_1997 st073024 93.8 µM 1.09127216137106 0.115846924518217 no 395 0.13757657176714 151 686268 SGTC_292 k038-0015 474 µM 1.08197857738255 0.117748897430855 no 396 0.139631023547806 161 46368540 SGTC_2101 5377231 179.231 µM 1.07426619664456 0.119343965971061 no 397 0.141351695447839 180 2844213 SGTC_325 2810-4341 181 µM 1.07299192917458 0.119608969852411 no 398 0.141637368663195 157 774970 SGTC_1271 0832-2808 169 µM 1.07251093688052 0.119709107557247 no 399 0.141745302120271 193 3663794 SGTC_1946 st076057 65.1 µM 1.07193047460818 0.119830032608604 no 400 0.14187563055108 154 953009 SGTC_2867 9039098 71.43 µM 1.07052000833439 0.120124227426506 no 401 0.142192653872201 168 6463460 SGTC_1059 3448-6867 171 µM 1.07043731868991 0.120141490599295 no 402 0.142211254467 179 3934407 SGTC_2167 5876490 200 µM 1.06685504086034 0.120891044133334 no 403 0.143018649741979 172 686534 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.06356272201461 0.121582823502507 no 404 0.143763418634517 188 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2765 myclobutanil 7.74 µM 1.06294995671765 0.121711883749913 no 405 0.143902323104949 186 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2612 dictamnine 15.46 µM 1.06244223768371 0.121818892120818 no 406 0.144017483763286 184 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_652 0437-0092 114 µM 1.05699466520397 0.122971198948298 no 407 0.145257011083551 163 3091274 SGTC_356 1634-0012 32.5 µM 1.05592464487966 0.123198431764481 no 408 0.145501321812138 190 735457 SGTC_344 k064-0035 6.43 µM 1.05432012575382 0.123539723581081 no 409 0.145868188757475 179 5088750 SGTC_1766 st045414 44.774 µM 1.05399286894632 0.123609414489617 no 410 0.145943090991253 164 253960 SGTC_15 0266-0086 27.098 µM 1.05294346287773 0.123833076220807 no 411 0.146183452365689 188 1712902 YIL048W NEO1 SGTC_1917 st066507 28.5 µM 1.04810246692154 0.124868513161829 no 412 0.14729569992207 186 3156428 SGTC_2350 9023895 38.85 µM 1.04610406303877 0.12529770932408 no 413 0.147756494775886 167 2997209 SGTC_997 3996-0078 137 µM 1.04573547942909 0.125376982197019 no 414 0.14784158864258 170 735687 SGTC_1506 4226-2149 212 µM 1.04535819425282 0.125458162806105 no 415 0.147928725391436 166 991114 SGTC_369 0957-0393 4.5 µM 1.04513612565865 0.125505962546485 no 416 0.14798002981466 167 6997992 SGTC_1938 st074717 56.4 µM 1.03979155800875 0.126660203404282 no 417 0.149218376029526 178 17250979 SGTC_3292 9120825 59.784 µM 1.03760091967346 0.127135434641359 no 418 0.14972794479081 180 24824900 SGTC_2523 spermine 47.74 µM 1.03709860763039 0.127244579513248 no 419 0.14984495202082 154 1103 A DNA binding polyamine. SGTC_1351 1496-0003 46.5 µM 1.03446435634817 0.127818030028102 no 420 0.150459565834832 182 3891978 SGTC_2346 9031566 143.75 µM 1.03314002331939 0.12810700168142 no 421 0.150769187843043 164 4771086 SGTC_2708 st078559 56 µM 1.03300558623619 0.128136361425327 no 422 0.150800642217427 152 17250902 SGTC_1461 k072-0203 53.8 µM 1.03227140822471 0.128296781171545 no 423 0.150972495629315 162 5418714 SGTC_1031 k035-0009 16 µM 1.03225626794703 0.128300090827271 no 424 0.15097604097525 186 5180959 SGTC_1811 st050069 61.5 µM 1.0310235245793 0.128569766735626 no 425 0.151264894110991 168 3877702 SGTC_699 0375-0592 111 µM 1.03089863167503 0.128597110335938 no 426 0.151294179177153 140 762578 SGTC_79 0052-0007 94.094 µM 1.03037639585234 0.128711490473613 no 427 0.15141667462619 175 2801472 SGTC_1313 1220-0047 237 µM 1.02583926214207 0.129708184677962 no 428 0.152483677998631 187 3528706 SGTC_1416 3966-0321 25.3 µM 1.02567725821156 0.129743871434474 no 429 0.152521868699761 177 582530 YLR208W SEC13 SGTC_2263 7948595 193.29 µM 1.02226339226992 0.130497470646878 no 430 0.153328127281612 167 2971371 SGTC_491 tetrandrine 80.3 µM 1.0219616658532 0.130564221017851 no 431 0.153399522090199 165 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_896 0964-0007 44.5 µM 1.02061219677962 0.130863050445615 no 432 0.153719104280465 177 6756758 SGTC_1102 cgs 12066b 26.1 µM 1.01978540457639 0.1310463704885 no 433 0.153915123373752 156 6438352 A 5-HT1B full agonist. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.0193299853164 0.131147423815367 no 434 0.154023166554147 180 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2148 5546263 113.568 µM 1.01922974956871 0.131169672427099 no 435 0.154046953112144 170 792097 SGTC_1139 k015-0024 46.9 µM 1.01773279065627 0.131502251901507 no 436 0.154402479814643 180 2766652 SGTC_1676 st018489 23.4 µM 1.01769765388728 0.131510065225649 no 437 0.154410831283728 169 3696235 SGTC_2204 7233102 200 µM 1.01673683876829 0.131723844810396 no 438 0.154639317985681 162 2172480 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.01551903282082 0.131995148785126 no 439 0.154929239310602 163 5379071 SGTC_2810 7959871 45.46 µM 1.01372643387894 0.132395206427144 no 440 0.155356653522311 192 2974535 SGTC_1663 st014140 55.4 µM 1.013560735447 0.132432227799746 no 441 0.155396200697569 172 4207120 SGTC_1783 st039459 87.517 µM 1.01179610935292 0.132826934063481 no 442 0.155817775310212 188 729761 SGTC_2052 5265182 7.135 µM 1.01164606305334 0.132860533299299 no 443 0.155853656586192 179 1239884 SGTC_1227 3909-8010 46.6 µM 1.00996813871356 0.133236662485725 no 444 0.156255277550202 156 15982272 SGTC_2742 clothiapine 36.27 µM 1.00717333309054 0.133864780838408 no 445 0.15692574278142 136 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_426 0988-0037 14.6 µM 1.00601698246333 0.134125259049817 no 446 0.157203700462476 205 5383008 SGTC_1446 4239-0190 62 µM 1.00502771868143 0.134348375655904 no 447 0.157441751449121 180 1340085 SGTC_2545 solidagenone 89.61 µM 1.00426788735066 0.134519919482787 no 448 0.157624753862097 143 6708572 An anti ulcer agent SGTC_571 k831-0106 44.2 µM 1.00306869983296 0.134790960654456 no 449 0.157913857717074 191 4783639 SGTC_730 1436-0052 41.2 µM 1.00253596495115 0.134911489875791 no 450 0.158042402725209 159 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2358 9037157 4 µM 1.00198287906181 0.135036701634879 no 451 0.158175930939308 198 2388925 SGTC_219 mitoxanthrone 164.414 µM 0.999770714506906 0.135538304871386 no 452 0.158710740668765 187 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2004 4023728 41.89 µM 0.997409058168241 0.136075212374682 no 453 0.159282998175031 221 360084 YDR527W RBA50 SGTC_2363 9053361 176 µM 0.996955471168899 0.136178498913639 no 454 0.159393062208977 188 6469797 YMR079W SEC14 SGTC_2060 5238662 140 µM 0.99562741940607 0.136481218755385 no 455 0.159715603593332 183 790130 SGTC_183 3914-0051 30.55 µM 0.994899464928722 0.136647345888638 no 456 0.15989258157404 160 1596232 SGTC_128 0906-2981 13.371 µM 0.991299174348904 0.137471003934105 no 457 0.160769758022671 209 6740226 SGTC_1509 1326-1131 80 µM 0.990897966870363 0.137562999815534 no 458 0.160867702618947 167 768313 SGTC_978 1416-0512 87.4 µM 0.990250490696603 0.137711553115356 no 459 0.161025849592138 181 6814003 SGTC_649 1123-0311 367 µM 0.989833556298315 0.137807270128295 no 460 0.161127740096871 196 693629 YIL048W NEO1 SGTC_2771 fluoxetine 41.05 µM 0.987866357628254 0.138259498721402 no 461 0.161609051832581 175 3386 A selective serotonin reuptake inhibitor. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.987478254396957 0.138348837012178 no 462 0.161704119082866 181 3256 An antibiotic and ribosome inhibitor. SGTC_3000 9075062 71.4286 µM 0.987428718245726 0.138360242672925 no 463 0.16171625575961 176 17057871 SGTC_1084 voriconazole 435 nM 0.986908067703234 0.138480160829115 no 464 0.161843854413499 198 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1846 st056244 14.8 µM 0.981720095440122 0.139678942718686 no 465 0.163118881275192 180 5393182 SGTC_2151 5563267 85.4165 µM 0.981672930219469 0.139689873427002 no 466 0.163130502744798 207 5310824 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.981340354667079 0.139766965507797 no 467 0.163212464347803 187 23847180 SGTC_467 ro 31-8220 72.8 µM 0.979389935424311 0.140219661090665 no 468 0.163693674064514 192 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_74 000s-0487 160.283 µM 0.977102213653762 0.140751913041167 no 469 0.164259275983585 189 677548 SGTC_112 phenothiazine 287.218 µM 0.974853386043649 0.141276450571691 no 470 0.164816495585789 185 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1602 st001878 87.6 µM 0.969262669787343 0.142586217630798 no 471 0.166207074855168 211 595405 YLR310C CDC25 SGTC_784 4579-0127 173 µM 0.963944520218394 0.143839726726979 no 472 0.167536870861702 203 1948547 SGTC_1557 sumaresinolic acid 42.3 µM 0.963852218335626 0.143861548083321 no 473 0.167560011168344 172 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2199 6590217 200 µM 0.963133626435401 0.144031508852326 no 474 0.167740234310636 172 703109 SGTC_1207 2099-0101 141 µM 0.959166019147391 0.144972361391842 no 475 0.168737558038917 197 5837381 SGTC_2324 6149169 200 µM 0.958413037584701 0.145151384588451 no 476 0.168927261766645 194 2888231 SGTC_118 0083-0097 135.343 µM 0.953685804138318 0.146278693814832 no 477 0.170121354019296 235 5207356 SGTC_608 k048-0125 159 µM 0.953208348240538 0.14639287933314 no 478 0.170242258715112 192 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1053 3366-3204 134 µM 0.949175383010049 0.147359766605768 no 479 0.171265709780825 203 3632071 YPR165W RHO1 SGTC_676 falcarinol 140 µM 0.946908720322958 0.14790506428844 no 480 0.171842646983305 208 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_452 diindolylmethane 8 µM 0.946514453610238 0.148000051930358 no 481 0.171943126879316 188 3071 Inhibits expression of several cancer promoting factors. SGTC_2130 NSC 7 2.4545 µM 0.94463893526612 0.148452465122115 no 482 0.172421621112587 189 21448 SGTC_2998 9066762 71.4286 µM 0.942124804963443 0.149060373915484 no 483 0.173064373126882 185 4945196 SGTC_1480 1070-0044 41.2 µM 0.940513575975055 0.149450837114108 no 484 0.173477094638251 191 3124987 SGTC_569 4130-2812 160 µM 0.940147389431575 0.149539673424679 no 485 0.173570981798941 184 743552 SGTC_80 0159-0065 512.242 µM 0.938915084368001 0.149838887599457 no 486 0.173887171931132 178 1548079 SGTC_154 3389-1638 511.116 µM 0.938123591960295 0.150031279166676 no 487 0.17409044951976 194 5238686 SGTC_2934 9036370 36.88 µM 0.937913556080523 0.150082361159146 no 488 0.174144418012912 174 6462800 SGTC_3287 9117173 37.0625 µM 0.937684760404578 0.150138018840232 no 489 0.174203218915 161 2789709 SGTC_3152 9099253 49.47 µM 0.937053667837395 0.150291612058153 no 490 0.174365476238866 219 25236131 SGTC_3269 9137823 49.47 µM 0.935310592051479 0.150716379901433 no 491 0.174814129115587 160 17682936 SGTC_2093 5331342 194.4 µM 0.934394309824649 0.150939987752749 no 492 0.175050265924296 206 33839 SGTC_3202 9113761 49.47 µM 0.934336353080831 0.150954138832404 no 493 0.175065208866822 201 4798415 SGTC_2360 9040895 200 µM 0.933879503574095 0.15106571696644 no 494 0.175183026351209 191 4914414 SGTC_4 0960-0234 25.671 µM 0.933423261879128 0.151177201408166 no 495 0.175300737262634 196 6821112 SGTC_1170 0310-0127 64.8 µM 0.931607106373915 0.15162152858683 no 496 0.175769804607535 224 774975 SGTC_2176 5809774 33.9695 µM 0.930597538315733 0.151868897053468 no 497 0.176030894182359 177 2870539 SGTC_781 4335-2806 94.4 µM 0.930504974911126 0.151891590726307 no 498 0.176054844761649 207 845254 SGTC_1119 parthenolide 318.541 nM 0.929951933872458 0.152027226157514 no 499 0.176197985908754 221 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_155 k072-0202 43.6 µM 0.929603669682399 0.152112680550181 no 500 0.176288163363131 213 5857737 SGTC_816 0325-0417 81.3 µM 0.928738908750244 0.15232500686029 no 501 0.17651220567133 200 68101 SGTC_1293 1000-1278 195 µM 0.927513749001092 0.152626159193512 no 502 0.17682992829162 199 678847 SGTC_2861 9024595 19.48 µM 0.926418985769976 0.152895593150647 no 503 0.177114140601314 164 16482810 SGTC_218 alverine citrate 93.75 µM 0.92516731493313 0.153204030089752 no 504 0.177439441171433 205 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2248 tofa 1.1 µM 0.924275237769662 0.153424107377979 no 505 0.177671515888814 212 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_296 1222-0039 74.9 µM 0.921698177947243 0.154061049120623 no 506 0.178343015622074 182 5984176 SGTC_2158 5657123 3.6195 µM 0.91935805793998 0.154640942615219 no 507 0.178954159808828 210 2858827 SGTC_1370 2001-0092 44.6 µM 0.914265760452532 0.155907817963572 no 508 0.180288608655388 213 790957 SGTC_926 2268-1401 59.4 µM 0.914248688783919 0.15591207657311 no 509 0.180293092803849 228 2931578 SGTC_2387 9077560 195.08 µM 0.913918386355636 0.155994487190858 no 510 0.180379865828142 198 5303272 SGTC_935 2996-0153 430 µM 0.913604744178497 0.156072767637601 no 511 0.180462286323817 217 23738523 SGTC_925 2064-1272 59.6 µM 0.91237749077818 0.156379320709896 no 512 0.180785017275655 208 6815817 SGTC_2658 polymyxin b sulfate 77.05 µM 0.912325655023039 0.156392277377891 no 513 0.180798656488416 213 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2567 aureobasidin a 60 nM 0.911113038733055 0.156695580048995 no 514 0.18111790853331 235 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_683 panaxydol 45 µM 0.909981004799993 0.156979076450353 no 515 0.181416263742187 175 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2779 methotrexate 400 µM 0.909290743018497 0.157152104894647 no 516 0.181598337828323 214 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1422 4031-0024 15.5 µM 0.907717266694798 0.157546998027715 no 517 0.182013809467491 225 782427 SGTC_2407 paclitaxel 400 µM 0.906127997203344 0.157946516069076 no 518 0.182434054044603 214 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2588 indole-3-carbinol 100 µM 0.905625480208209 0.15807297945528 no 519 0.182567058761445 207 3712 Induces cell cycle arrest. SGTC_2896 9052656 71.43 µM 0.904515445824411 0.158352566126648 no 520 0.182861073958369 222 6469436 SGTC_330 1488-0319 80.1 µM 0.902666145687889 0.158819073247105 no 521 0.183351554603849 219 6846614 SGTC_1246 0422-0085 105 µM 0.90179399693625 0.15903939503307 no 522 0.183583154641024 220 264295 SGTC_546 peri-Naphthalide 147 µM 0.897745251085173 0.160064808522987 no 523 0.184660689415051 215 223824 A penicillin ester. SGTC_959 1222-0044 107 µM 0.897198784591613 0.160203540805285 no 524 0.184806426826077 203 6083612 SGTC_1521 st012942 49.4 µM 0.896775474829033 0.160311061110029 no 525 0.184919368634933 200 24207259 SGTC_3249 9135183 49.47 µM 0.896562188029669 0.160365253631669 no 526 0.184976291192547 202 4902779 SGTC_671 0560-0003 407 µM 0.896383065751776 0.160410774781248 no 527 0.18502410424043 182 3238678 SGTC_2946 9065502 71.43 µM 0.895529264366516 0.160627871191957 no 528 0.18525211466113 162 16489101 SGTC_1998 st075797 76.8 µM 0.894636460708304 0.160855089880019 no 529 0.18549072730111 206 24208315 SGTC_729 4092-0585 94.1 µM 0.894132884492255 0.160983342626456 no 530 0.18562539827412 201 2169061 SGTC_135 0933-0004 26.348 µM 0.893712516268988 0.161090454735051 no 531 0.185737863449038 206 21230617 YGL099W LSG1 SGTC_2452 5863136 48.41 µM 0.890417781021971 0.161931581450888 no 532 0.186620799127389 223 2184096 SGTC_3090 9117696 49.47 µM 0.885188484525188 0.16327245390529 no 533 0.188027491030992 195 7923821 SGTC_1759 st043059 70 µM 0.882552762218593 0.163951020407611 no 534 0.188738980280358 217 669426 SGTC_2738 aclarubicin 5.55 µM 0.88206225213762 0.164077503857466 no 535 0.188871571920119 177 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3326 9140064 16.379 µM 0.881871828574662 0.164126623731267 no 536 0.18892306149749 208 1868434 SGTC_937 3122-0005 46.7 µM 0.881662862512806 0.164180537629124 no 537 0.188979574825023 229 759535 SGTC_1268 0828-0275 2.46 µM 0.88125827209276 0.164284955867613 no 538 0.189089022912107 214 745337 SGTC_2973 9094665 17.96 µM 0.880250423727397 0.164545252409263 no 539 0.189361831485467 229 25237061 YIL048W NEO1 SGTC_650 1328-0195 38 µM 0.878606000435982 0.164970530367542 no 540 0.189807470602644 225 2780821 SGTC_75 0159-0059 199.013 µM 0.878499889402695 0.164997997046389 no 541 0.189836248851619 224 5377270 SGTC_1762 st045503 25.4615 µM 0.877519384764974 0.165251939256319 no 542 0.190102297284789 210 4645554 SGTC_728 3030-5151 22.5 µM 0.877494177774058 0.165258470981737 no 543 0.190109139925764 216 3125388 SGTC_975 1335-0046 28.5 µM 0.877099608769092 0.165360734886032 no 544 0.190216268590726 223 16486740 SGTC_2647 atorvastatin 60.16 µM 0.876656412927295 0.165475650647912 no 545 0.190336644051161 193 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2856 9022925 19.48 µM 0.875137279624703 0.165869936952137 no 546 0.190749607487553 203 4944862 SGTC_1039 k821-0043 94 µM 0.872449096124933 0.16656913331718 no 547 0.191481713327499 204 15992768 SGTC_2064 5220758 200 µM 0.872231773750661 0.16662574184889 no 548 0.191540974504048 231 788518 SGTC_2707 st078556 66.6 µM 0.872166209719828 0.166642822525894 no 549 0.191558855226263 197 17250899 SGTC_751 0833-0568 350 µM 0.868622700769438 0.167567654696691 no 550 0.192526766893459 223 6954252 SGTC_2757 clomiphene 4.22 µM 0.868044941078399 0.167718759008769 no 551 0.192684865301345 242 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3072 9116419 49.47 µM 0.867681666240557 0.16781381296689 no 552 0.192784312594357 219 17170162 SGTC_1297 1068-0111 14.1 µM 0.860033822179097 0.169822984703169 no 553 0.194885199377666 230 767057 SGTC_2744 captopril 92.04 µM 0.85466314161411 0.171243101617213 no 554 0.1963688305442 157 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_120 rhodamine 6G 52.259 µM 0.85411613266235 0.171388166738659 no 555 0.196520322996648 258 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1709 st033179 39.1045 µM 0.85203730028872 0.171940183043535 no 556 0.197096694908088 221 573381 SGTC_807 1315-0151 48 µM 0.850917880961385 0.172237905045186 no 557 0.197407485634695 251 4011080 SGTC_2000 st075254 36.4 µM 0.850747945403574 0.172283130035526 no 558 0.197454691702375 214 17234175 SGTC_522 1273-0010 11.6 µM 0.84752207481162 0.173143068440458 no 559 0.198352094092506 227 5705015 SGTC_716 1683-5115 658 µM 0.846207744688789 0.173494219266196 no 560 0.198718431124191 238 723597 SGTC_2435 5706476 10.6 µM 0.846095992375396 0.173524097131206 no 561 0.19874959812626 208 5725375 SGTC_2739 tacrine 100.86 µM 0.84596119492985 0.17356014065138 no 562 0.198787196188928 200 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1333 1482-0047 286 µM 0.844932559332215 0.173835344638833 no 563 0.199074247155477 221 3811116 SGTC_1860 st056228 74.6 µM 0.838404493892891 0.175588345496159 no 564 0.200901783201544 248 688679 SGTC_2536 dehydroabietamide 32.04 µM 0.837154280729337 0.175925342750547 no 565 0.201252926234964 208 3983547 SGTC_3018 9082602 49.47 µM 0.833963634708436 0.176787242246721 no 566 0.202150738190297 236 17332089 SGTC_280 3448-3607 3.04 µM 0.833915118870803 0.176800368555479 no 567 0.202164408472828 193 626179 SGTC_2174 5790901 200 µM 0.833824627605336 0.176824853264237 no 568 0.202189907627865 229 786020 SGTC_2926 9010726 65.15 µM 0.833659655007258 0.176869496303225 no 569 0.202236399517234 223 2994293 SGTC_1254 0550-0035 264 µM 0.832418030551578 0.177205719353981 no 570 0.202586514084683 223 15121435 SGTC_190 3970-0790 3.722 µM 0.831795529382079 0.177374440060902 no 571 0.202762183889201 218 2832352 SGTC_2056 5235370 200 µM 0.831377169451191 0.177487887953141 no 572 0.202880296166779 213 5511916 SGTC_913 3487-1245 167 µM 0.830154408059816 0.177819730244169 no 573 0.203225744318711 228 4016153 SGTC_1496 4469-0713 57.4 µM 0.828669869852815 0.178223141153803 no 574 0.203645619811325 232 746691 SGTC_3353 9151644 39.2805 µM 0.828647325594968 0.178229271811219 no 575 0.203652000042453 209 4909158 SGTC_2205 7238770 200 µM 0.828461987135879 0.178279677558782 no 576 0.20370445703893 212 279867 SGTC_2108 5365811 200 µM 0.826853721301164 0.178717448210196 no 577 0.204159988337636 227 780283 SGTC_314 1671-0008 2.74 µM 0.826220243110691 0.178890066881557 no 578 0.204339583521957 240 3913060 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.825788747611376 0.179007706649062 no 579 0.204461969136056 201 4000243 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.824673039264925 0.179312110777559 no 580 0.204778621081568 242 688788 SGTC_1508 1080-0625 72.9 µM 0.824432527254422 0.179377773460662 no 581 0.204846919584535 227 767111 SGTC_3073 9114972 49.47 µM 0.824116245399289 0.179464145235441 no 582 0.204936755163232 209 41905075 SGTC_894 0960-0238 55.9 µM 0.823908402245686 0.179520918279034 no 583 0.204995802948586 253 6741907 YDL195W SEC31 SGTC_2420 aureobasidin a 50 nM 0.823714424759301 0.179573914052878 no 584 0.205050920651224 213 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.823546035718622 0.179619926886513 no 585 0.205098774670363 237 390807 SGTC_1390 3413-2614 145 µM 0.820987459566797 0.180319977184094 no 586 0.205826705673914 256 3421432 SGTC_2922 7999257 32.47 µM 0.819495526031997 0.180728973241315 no 587 0.206251876748021 248 2988377 SGTC_3189 9110682 49.47 µM 0.818683497448641 0.180951825572771 no 588 0.206483507191214 219 17122418 SGTC_1138 3761-0006 1.03 µM 0.815939513618132 0.181706155200224 no 589 0.207267365605686 217 12061087 SGTC_739 1486-1183 203 µM 0.815720601562913 0.181766419424169 no 590 0.207329976681946 216 4346692 SGTC_827 3253-0474 693 µM 0.815474910582563 0.181834070498878 no 591 0.207400260120242 239 5402065 SGTC_1903 st060211 78.3 µM 0.814096208309134 0.182213988619546 no 592 0.207794918938487 224 688960 SGTC_2916 7875993 68.79 µM 0.813711044082884 0.182320213886214 no 593 0.20790525289263 257 1299250 SGTC_3076 9116187 49.47 µM 0.809929146713092 0.183365285823503 no 594 0.208990449486775 216 27241210 SGTC_2753 fluvastatin 17.09 µM 0.809443439469127 0.183499774024387 no 595 0.209130062105816 238 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1211 1056-0033 32.3 µM 0.805123025037493 0.184698764265853 no 596 0.210374345053393 232 6741922 SGTC_2345 9052315 157.45 µM 0.80307509076313 0.185268799356868 no 597 0.210965667019293 231 6469265 SGTC_722 3534-0461 190 µM 0.803014713677117 0.185285621661932 no 598 0.210983115116002 226 658262 SGTC_1320 1313-0481 95.3 µM 0.80262113541644 0.185395303947835 no 599 0.211096874219587 219 6813365 YLR208W SEC13 SGTC_3007 9078383 71.4286 µM 0.80137894464361 0.185741741628088 no 600 0.211456150351952 228 6496995 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.801176865032653 0.185798138069321 no 601 0.211514631243415 247 756377 SGTC_2650 prasterone 100 µM 0.800382911046451 0.18601981781996 no 602 0.211744489478687 209 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1073 triclabendazole 3.09 µM 0.799601541828133 0.186238143804216 no 603 0.21197084694642 232 50248 An antihelmetic and likely tubulin inhibitor. SGTC_354 2783-3500 4.88 µM 0.799392234710574 0.186296654226674 no 604 0.212031505852249 233 6740761 SGTC_3332 9141069 11.198 µM 0.798947295544907 0.186421071866834 no 605 0.212160486564213 231 17332883 SGTC_3111 9122088 49.47 µM 0.796857882339727 0.187006019288964 no 606 0.212766787024619 233 16876704 SGTC_65 0798-0905 34.986 µM 0.795521373853916 0.187380779991682 no 607 0.213155141439242 237 3602145 SGTC_1570 verbenone 133 µM 0.79488137949016 0.187560400459106 no 608 0.213341253359668 237 29025 A natural terpanoid with antifungal properties. SGTC_276 colchicine 750 µM 0.794504236861036 0.187666298907534 no 609 0.213450971704154 238 2833 A microtubule depolymerizer. SGTC_439 amiodarone 34.4 µM 0.792951535343447 0.188102673269672 no 610 0.213903029961027 240 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.791448406690318 0.188525711636078 no 611 0.214341185964092 260 229346 A bile salt which induces apoptosis. SGTC_2200 6600604 21.907 µM 0.790939501986898 0.18866906987666 no 612 0.214489647855522 265 2904777 SGTC_3177 9107506 49.47 µM 0.790747575720161 0.188723152871258 no 613 0.21454565369634 226 8897194 SGTC_1373 2887-0003 58.5 µM 0.789937913500469 0.188951413144602 no 614 0.214782014100764 260 776948 SGTC_3272 9137413 49.47 µM 0.78937245607036 0.189110927939546 no 615 0.214947174781181 250 17614870 SGTC_2662 daunorubicin 22.37 µM 0.789355911751208 0.189115596318551 no 616 0.214952008211123 233 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2712 st079126 47.7 µM 0.788273818823849 0.189421089070093 no 617 0.215268279180141 240 3152970 SGTC_72 0744-0168 198.391 µM 0.788065274419537 0.189479999496164 no 618 0.215329262954696 252 677577 SGTC_3289 9119912 71.43 µM 0.787590528427789 0.189614149611584 no 619 0.215468128333898 252 17014829 SGTC_1089 terbinafine 2.25 µM 0.787396211554741 0.189669075044984 no 620 0.215524981889119 236 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2808 7946468 45.46 µM 0.785828810701351 0.190112472928719 no 621 0.215983892675286 256 2970879 SGTC_1945 st075991 56.6 µM 0.78245370299972 0.191069408498546 no 622 0.216973991779163 227 1084980 SGTC_2491 paeonol 100 µM 0.781097099336588 0.191454873623165 no 623 0.217372693909181 252 11092 Increases levels of cortical cytochrome oxidase. SGTC_2884 9058502 51.95 µM 0.780994988149077 0.191483906747279 no 624 0.217402721219113 234 6471554 SGTC_1934 st074720 32.6 µM 0.780443465986031 0.191640766861711 no 625 0.217564945889848 245 17250992 SGTC_2785 7756463 72.73 µM 0.779680004394589 0.19185803515514 no 626 0.217789625654329 292 2201551 SGTC_527 4476-4215 268 µM 0.778805972298851 0.192106955003145 no 627 0.218047009551755 216 4418754 SGTC_428 3448-4153 16.5 µM 0.777415391141956 0.192503392424435 no 628 0.218456867386783 236 3834874 SGTC_1799 st045822 46.1415 µM 0.777297516380201 0.192537020033604 no 629 0.21849163000632 243 3674992 SGTC_478 N-arachidonylglycine 10 µM 0.776803428187597 0.19267801382542 no 630 0.218637376938037 200 5283389 SGTC_3270 9137563 49.47 µM 0.776560067199188 0.192747482889713 no 631 0.218709184521319 228 17015724 SGTC_914 3820-6779 408 µM 0.775627075218975 0.193013953623628 no 632 0.21898460458647 236 2893481 SGTC_637 1181-0519 7.26 µM 0.774680201081573 0.193284619101674 no 633 0.219264326529239 247 6252091 YGR060W ERG25 SGTC_1590 st077108 57.8 µM 0.774323928316518 0.193386520183659 no 634 0.219369628419694 221 5489485 SGTC_727 3032-0951 202 µM 0.774197659288793 0.19342264349766 no 635 0.219406956144748 241 3652836 SGTC_2369 9071472 200 µM 0.773890573756094 0.193510512363371 no 636 0.219497752181358 247 17296037 SGTC_2814 7977482 42.97 µM 0.773633587564062 0.19358406461079 no 637 0.219573751923157 244 6456762 SGTC_2434 5670830 169.91 µM 0.771572422931116 0.194174608963625 no 638 0.220183856360586 250 1549830 SGTC_291 SEC14.278 35.5 µM 0.770781596149771 0.194401479730075 no 639 0.220418198790901 248 1068044 SGTC_1472 k841-0093 193 µM 0.770547344498248 0.19446871233095 no 640 0.220487641048012 248 X1472 SGTC_867 0518-0118 155 µM 0.770458154080274 0.194494314605751 no 641 0.220514084216252 257 6848158 SGTC_205 1486-1330 71.903 µM 0.770422230115107 0.194504627226083 no 642 0.220524735464036 242 4118834 SGTC_2704 st078022 71.1 µM 0.77038207758299 0.194516154126482 no 643 0.220536640806338 242 54697681 SGTC_1067 clotrimazole 1.36 µM 0.769627356819094 0.194732895044775 no 644 0.220760486211166 234 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3237 9133362 49.47 µM 0.768644751026722 0.195015300102885 no 645 0.221052115760541 244 43845137 SGTC_606 k015-0008 38.6 µM 0.768360018682081 0.195097179887928 no 646 0.221136663226589 256 1970475 SGTC_206 4546-0025 72.014 µM 0.76724248007354 0.195418749648261 no 647 0.22146868014978 260 6620745 YIL048W NEO1 SGTC_1436 4092-1007 8.32 µM 0.766298346210115 0.195690673232635 no 648 0.221749401061433 216 2881121 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.766209977458659 0.195716136403077 no 649 0.221775686290875 235 6708739 YPR165W RHO1 SGTC_1739 st037196 92.5 µM 0.765890077211479 0.195808331443838 no 650 0.221870855300769 240 612214 SGTC_2327 6189656 200 µM 0.765327459708918 0.195970541365234 no 651 0.222038288267722 252 5349088 SGTC_2181 6316240 54.2555 µM 0.763175229674145 0.196591809231905 no 652 0.222679449614725 248 12779990 SGTC_2406 ethylparaben 405.7 µM 0.763047938439092 0.196628590758915 no 653 0.222717403408713 231 8434 A possible steroid mimic. SGTC_2340 7987427 183.45 µM 0.762458053464827 0.196799095796489 no 654 0.222893334598828 239 2239331 SGTC_789 1309-1135 70.6 µM 0.762454033500282 0.196800258066037 no 655 0.222894533811147 233 3092424 SGTC_1773 st048542 73.5835 µM 0.762291640070655 0.196847213432798 no 656 0.222942981142876 261 3237138 SGTC_33 0986-0033 35.816 µM 0.762062195393821 0.196913567943284 no 657 0.223011442303057 220 2848082 SGTC_1796 st049173 110.4 µM 0.758555897983002 0.197929259315608 no 658 0.224059131463655 269 94134 SGTC_1025 k007-0731 70 µM 0.757946374720153 0.198106146099867 no 659 0.224241543156779 258 6256118 SGTC_2746 daunorubicin 9.88 µM 0.757818044735554 0.198143400281021 no 660 0.224279959143578 218 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1751 st044839 27.194 µM 0.757129402764644 0.198343385210778 no 661 0.224486170106662 241 5291326 SGTC_791 1348-1292 225 µM 0.756795569816919 0.19844037572055 no 662 0.224586173695461 251 5437054 SGTC_3226 9131256 49.47 µM 0.756216844059778 0.198608584211255 no 663 0.224759597676974 227 17178073 SGTC_2077 5212015 200 µM 0.753442933265433 0.199416023454522 no 664 0.225591895794551 238 780900 SGTC_1183 1254-0324 198 µM 0.752969002410883 0.199554174236613 no 665 0.225734270632324 233 5799357 SGTC_2608 thymoquinone 42.66 µM 0.752192572702624 0.199780627838333 no 666 0.225967629774523 251 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2289 7946404 165.07 µM 0.751352962066269 0.200025682681251 no 667 0.226220131621477 245 1246120 YPR165W RHO1 SGTC_2933 9026794 32.47 µM 0.749234945690883 0.200644664707198 no 668 0.226857804953951 246 17586027 SGTC_659 k018-0002 107 µM 0.748946535520966 0.200729040322035 no 669 0.2269447152637 257 6797879 YHR007C ERG11 SGTC_1531 st059297 52.4 µM 0.746726580582531 0.201379210130644 no 670 0.227614310760653 260 7566702 SGTC_590 k048-0076 22.4 µM 0.746122611525303 0.201556315885284 no 671 0.227796675653946 264 6832814 SGTC_294 k038-0071 157 µM 0.744373813210699 0.202069653368385 no 672 0.228325178460018 259 24152826 SGTC_587 k089-0003 57 µM 0.744242585908136 0.202108205004451 no 673 0.228364864324749 259 9659696 SGTC_2972 9093619 59.92 µM 0.744207145794479 0.202118617269132 no 674 0.228375582816748 234 25236256 SGTC_1344 1488-0097 29.1 µM 0.742536022756462 0.202609955621043 no 675 0.228881317361157 274 747966 SGTC_686 1319-0111 510 µM 0.741300154506426 0.202973780510087 no 676 0.22925573402494 297 4562600 SGTC_424 splitomicin 100 mM 0.740874398734545 0.203099208239483 no 677 0.2293847998007 268 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_102 gallobenzophenone 83.616 µM 0.740525334296004 0.203202077202215 no 678 0.229490647351741 247 70837 SGTC_2642 cholecalciferol 100 µM 0.738442979593473 0.203816391052184 no 679 0.230122652523103 250 9821465 A vitamin D precursor, similar to steriods. SGTC_2219 9098279 200 µM 0.737839756887896 0.203994553889293 no 680 0.230305915394528 230 902349 SGTC_891 0929-0073 133 µM 0.736909492501491 0.204269490853547 no 681 0.230588695508717 266 5603632 SGTC_2745 rifampicin 24.3 µM 0.736085746229416 0.204513130790149 no 682 0.230839258322432 217 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2586 curcumin 80 µM 0.735471557020512 0.204694902398073 no 683 0.231026178073485 248 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_790 1575-0012 79.1 µM 0.735245298507092 0.204761888672353 no 684 0.231095057922452 267 378741 YLR208W SEC13 SGTC_1730 st033808 45.1 µM 0.734091199259134 0.205103775022348 no 685 0.231446578471336 266 1045166 SGTC_404 fumagillin 50 µM 0.733964519230306 0.205141322925617 no 686 0.231485181373786 270 12015870 A methionine aminopeptidase binder. SGTC_1238 0333-0287 48.8 µM 0.733260235251015 0.205350146849945 no 687 0.231699861589414 256 7226 SGTC_2496 diffractaic acid 79.83 µM 0.73266450275439 0.205526883216977 no 688 0.231881539660003 277 94870 An apoptosis inducer which activates caspases. SGTC_3236 9132701 49.47 µM 0.731406447263859 0.205900408006852 no 689 0.232265464196702 258 24282524 SGTC_2078 5212016 200 µM 0.730986914989803 0.206025059327354 no 690 0.232393572705227 255 1899708 SGTC_1440 4100-1550 40 µM 0.728841956685696 0.20666306778091 no 691 0.233049171643854 276 742806 SGTC_2250 alverine citrate 130 µM 0.727938072838313 0.206932274093056 no 692 0.233325747826718 251 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1975 st070967 30.8 µM 0.727594132409257 0.207034765339796 no 693 0.233431036746193 267 261391 SGTC_1664 st014217 9.02 µM 0.727415366029567 0.207088048021365 no 694 0.233485772093189 261 3982782 SGTC_878 0828-0289 13.7 µM 0.727369543721476 0.207101707015546 no 695 0.233499803281997 256 745350 YLR208W SEC13 SGTC_211 3455-0679 143.504 µM 0.727234959624902 0.207141827748496 no 696 0.233541016805414 232 748649 SGTC_734 2023-0417 80 µM 0.727120014624424 0.207176097529662 no 697 0.233576219466363 271 3935732 SGTC_874 0599-0792 117 µM 0.725362969638381 0.207700361415184 no 698 0.234114692137491 264 765305 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.723920881773246 0.208131233986447 no 699 0.234557154637102 245 17037758 SGTC_3265 9137266 49.47 µM 0.723793596122103 0.208169290202758 no 700 0.234596230720328 208 17224265 SGTC_1633 st005664 67.9 µM 0.723528069883145 0.208248691189098 no 701 0.234677757587873 260 2063822 SGTC_50 0929-0078 56.389 µM 0.721680543751589 0.208801656142517 no 702 0.235245453383244 234 1377751 SGTC_108 0509-0257 621.132 µM 0.721627127450654 0.208817656510797 no 703 0.235261878066794 265 536624 SGTC_1817 st052116 64.4 µM 0.721027884518063 0.208997203801824 no 704 0.235446179354869 258 4361398 SGTC_2474 5321570 43.32 µM 0.720922296143246 0.209028849984544 no 705 0.235478662040722 268 2841384 SGTC_455 paf C-16 10 µM 0.719825389402307 0.209357773832021 no 706 0.235816255250683 247 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.719508247151896 0.209452930399761 no 707 0.235913911310589 300 6728940 SGTC_1360 1598-0022 39.8 µM 0.719351927624871 0.209499842466453 no 708 0.235962054216948 269 761525 SGTC_334 1502-1024 68.5 µM 0.719274317355351 0.209523135890715 no 709 0.235985958449564 253 3296216 SGTC_3300 9124615 50.48 µM 0.71665679148089 0.21030963430633 no 710 0.236792946521721 243 24824903 SGTC_2563 tomatine 8.54 µM 0.716178095274512 0.210453657336853 no 711 0.236940693419122 280 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_558 k064-0027 21.3 µM 0.715223025155183 0.210741177617814 no 712 0.237235621803921 256 5088526 SGTC_1523 st012844 44.7 µM 0.714362409883278 0.211000459873167 no 713 0.237501554885226 259 4274103 SGTC_725 1497-0963 19 µM 0.713034951397232 0.211400757005292 no 714 0.237912064769713 259 3549977 SGTC_1779 st039427 55 µM 0.711694473095969 0.211805431266901 no 715 0.238326995445006 282 1124498 SGTC_2312 7706453 155.7 µM 0.711638944790783 0.211822204364869 no 716 0.23834419218118 253 976098 SGTC_2489 cantharidin 73.42 µM 0.711362423349511 0.211905743088275 no 717 0.238429839097149 263 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2651 TUB2.036 5 µM 0.709586380501158 0.212442755119239 no 718 0.238980333898932 260 15992207 YFL037W TUB2 SGTC_505 gw-5074 63.9 µM 0.709507935025493 0.212466492554304 no 719 0.239004664544446 270 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1456 k015-0012 13 µM 0.706468819187832 0.213387314824471 no 720 0.239948318392973 274 2989616 SGTC_2941 9056145 11.23 µM 0.705716722162449 0.213615551421496 no 721 0.240182159836359 262 2119517 SGTC_93 0109-0045 59.227 µM 0.705708114664858 0.213618164335541 no 722 0.240184836791733 273 88733 SGTC_414 piperonyl butoxide 100 µM 0.70538116792381 0.213717426912587 no 723 0.240286530163885 260 5794 A potent inhibitor of cytochrome P450. SGTC_169 k015-0017 16.025 µM 0.705221967106149 0.213765770758435 no 724 0.240336056408591 314 1840002 SGTC_826 1683-5028 118 µM 0.704949086271171 0.213848650152246 no 725 0.240420960634163 265 722377 SGTC_1153 4055-0057 267 µM 0.704061667407313 0.21411830642923 no 726 0.240697185325464 285 882706 SGTC_923 1900-2434 73.3 µM 0.70379883297234 0.214198210800364 no 727 0.240779030297744 288 5910570 SGTC_2380 9035439 200 µM 0.703781886664234 0.214203363247577 no 728 0.240784307789986 270 6462575 SGTC_763 3453-1109 128 µM 0.703415519700991 0.214314773071465 no 729 0.240898418755803 262 1560353 SGTC_2870 9038528 12.99 µM 0.703275603417951 0.214357329600304 no 730 0.240942005725362 267 6463316 SGTC_559 1550-0661 158 µM 0.701949861494872 0.21476080723964 no 731 0.24135521601013 265 5830875 SGTC_919 tnp00227 403.569 nM 0.701055763534934 0.215033166890538 no 732 0.241634107755177 285 1269246 A methoxyflavone. YNL221C POP1 SGTC_2747 doxorubicin 7.63 µM 0.698680270991053 0.215757761735514 no 733 0.242375933082778 220 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2362 9071156 126 µM 0.698507116376633 0.215810634252533 no 734 0.24243005449039 281 653133 SGTC_3193 9111931 49.47 µM 0.697612377575926 0.216083961110742 no 735 0.242709819381941 309 17087244 SGTC_1233 0325-0408 14.2 µM 0.697474523963384 0.216126090766505 no 736 0.242752938668328 266 12874 SGTC_2678 equilin 100 µM 0.696575994617771 0.216400808238479 no 737 0.243034091585296 241 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.695233433347179 0.216811660935187 no 738 0.243454511583403 273 1273210 SGTC_2246 7293507 91.5585 µM 0.695169082858849 0.216831364892276 no 739 0.243474672654967 269 887656 SGTC_1076 itraconazole 331 nM 0.69442306969628 0.217059867800848 no 740 0.243708465139867 261 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2451 5856223 45.7 µM 0.692906429231689 0.217524841643876 no 741 0.244184137344739 277 2179896 SGTC_1757 st041620 31.8375 µM 0.692357673060633 0.217693221647272 no 742 0.24435636997958 283 5289815 SGTC_1166 k206-0078 225 µM 0.686457545092208 0.219508358155272 no 743 0.246212313717377 265 5404595 SGTC_1469 k284-2957 126 µM 0.6860308870845 0.219639952966496 no 744 0.246346815664317 258 23884841 SGTC_179 1273-0063 6.77 µM 0.683621770193759 0.220383850310725 no 745 0.247107016998912 278 3108139 SGTC_537 1334-0398 209 µM 0.682856473019766 0.220620463933432 no 746 0.24734877030896 279 5846986 SGTC_2995 9067767 71.4286 µM 0.681975864583979 0.220892909339008 no 747 0.247627106195315 259 11673567 SGTC_2182 6325192 200 µM 0.681181264757931 0.22113891035936 no 748 0.247878400657406 256 736248 SGTC_641 4092-0595 30 µM 0.679610014814056 0.221625816477993 no 749 0.248375713366911 277 786260 SGTC_57 miconazole 162.5 nM 0.679072093249862 0.221792650743176 no 750 0.248546091807586 267 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2994 9053520 71.4286 µM 0.678458258335633 0.221983116848487 no 751 0.248740590686491 269 4647384 SGTC_1255 0566-0045 221 µM 0.677280881082459 0.222348705066621 no 752 0.249113879506232 269 2788469 SGTC_2443 5493264 126.67 µM 0.675375852652719 0.222940963609026 no 753 0.249718501564672 285 5340055 SGTC_3040 9091894 49.47 µM 0.673678722109853 0.223469344348228 no 754 0.250257796202051 244 25236966 SGTC_1668 st014914 51.6 µM 0.673527219264226 0.223516547509191 no 755 0.250305969042834 289 2839556 SGTC_2277 7947813 106.88 µM 0.673497224223818 0.223525893621509 no 756 0.250315507046065 278 1246798 SGTC_234 nsc-17383 10.7 µM 0.673280565034566 0.223593408753843 no 757 0.250384407359456 265 408974 SGTC_1621 st003705 32.4 µM 0.673208877540382 0.223615750496458 no 758 0.250407207086247 280 24207032 SGTC_512 prima-1 270 µM 0.672792933529862 0.223745406441058 no 759 0.250539517001632 267 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2761 levamisole 97.89 µM 0.671883410845828 0.224029067058437 no 760 0.250828961070096 287 26879 An alkaline phosphatase inhibitor. SGTC_3049 9092223 49.47 µM 0.671292711490492 0.224213402893007 no 761 0.251017038432403 277 8623917 SGTC_1106 tegaserod maleate 11.7 µM 0.670966237022761 0.224315320671808 no 762 0.251121019186422 283 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2825 7998094 58.44 µM 0.669210568001009 0.224863850723113 no 763 0.251680582920975 271 2987815 SGTC_2628 lathosterol 100 µM 0.667867286536317 0.225284050016692 no 764 0.252109155468813 268 6710616 SGTC_139 0099-0334 718.624 µM 0.667136447322133 0.225512854527119 no 765 0.252342490556638 296 97690 SGTC_2847 9005661 71.43 µM 0.667011121311054 0.225552103664594 no 766 0.252382514833051 258 2991449 SGTC_639 0833-0042 114 µM 0.666883671939589 0.22559202175277 no 767 0.252423220660009 301 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1032 k061-1018 98.7 µM 0.664397494570557 0.226371510143517 no 768 0.253217967995388 288 4005393 SGTC_757 1066-0008 322 µM 0.662097697116165 0.227093915472336 no 769 0.253954305803171 275 6842497 SGTC_694 1315-0438 43.2 µM 0.661588435298083 0.227254058819485 no 770 0.254117510561781 271 6793154 SGTC_3207 9114163 49.47 µM 0.660591073457663 0.227567875231084 no 771 0.254437297592464 317 849233 SGTC_3064 1327-0027 10 µM 0.65977370864195 0.227825238040346 no 772 0.254699528799029 264 16000455 YPR107C YTH1 SGTC_2737 bleomycin 30.5 nM 0.659205203970294 0.2280043390499 no 773 0.254882002821154 284 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2654 protoveratrine a 100 µM 0.659144382718693 0.228023504790331 no 774 0.254901528784301 309 5702278 A heart drug and vasodilator. SGTC_3085 9117376 49.47 µM 0.658851529702569 0.22811580010196 no 775 0.254995556834424 282 16480349 SGTC_3002 9075603 71.4286 µM 0.653566083962269 0.229785163276364 no 776 0.25669570050799 289 20105405 SGTC_2502 avocadyne acetate 18.59 µM 0.652892297563516 0.229998463499035 no 777 0.256912857468634 261 3952079 SGTC_367 0335-0881 7.1 µM 0.652570629990017 0.230100332706203 no 778 0.257016562529215 296 23828853 SGTC_2954 9074818 52.69 µM 0.652285152470623 0.230190761990783 no 779 0.257108618214892 295 16648742 SGTC_2237 6667747 47.222 µM 0.651894030613715 0.230314687972342 no 780 0.257234768030243 291 729940 YDL015C TSC13 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.651870218560273 0.230322233966514 no 781 0.257242449248903 274 1241132 A phosphatase inhibitor. SGTC_550 4123-0385 25.7 µM 0.650858367306166 0.230643015418991 no 782 0.257568959249555 280 5731123 SGTC_2888 9058547 12.99 µM 0.650185791444314 0.230856376353626 no 783 0.257786108928153 271 16476514 SGTC_399 oxolinic acid 75 µM 0.649671545526824 0.23101958467708 no 784 0.257952203844988 282 4628 A DNA gyrase inhibitor. SGTC_3259 9138485 49.47 µM 0.648229298450254 0.231477659950494 no 785 0.258418327399615 267 17646153 SGTC_236 1509-0011 5.31 µM 0.647424029867802 0.231733643227484 no 786 0.258678773940367 314 3107280 SGTC_1165 k072-0275 30.3 µM 0.646513633009277 0.232023235128259 no 787 0.258973385495092 291 6153523 YGL055W OLE1 SGTC_48 0382-0018 55 µM 0.646262217743709 0.232103244339877 no 788 0.259054776015292 261 762596 SGTC_621 3584-0052 32.1 µM 0.645604284896373 0.232312694458825 no 789 0.259267830822639 301 2273927 SGTC_648 0375-0473 33.3 µM 0.645325501192003 0.232401475771476 no 790 0.259358135136229 290 1713139 SGTC_2717 st081029 62.2815 µM 0.644867440206767 0.232547390602592 no 791 0.259506546672328 297 5292846 SGTC_1807 st050092 58.9 µM 0.644465770164566 0.232675384066451 no 792 0.259636723652167 291 5008496 SGTC_1140 3229-1848 2.98 µM 0.644114290362661 0.232787416362746 no 793 0.259750662159016 290 2849525 SGTC_563 tetrahydrosecaminediol 614 µM 0.643347261109543 0.233032006860497 no 794 0.259999398070435 299 334274 A psychoactive constituent of the cannabis plant. SGTC_2061 5245884 80.95 µM 0.641997868835214 0.233462647606174 no 795 0.260437283374094 308 573863 SGTC_2960 9079389 5.97 µM 0.641436466052921 0.233641941848866 no 796 0.260619573518456 272 16457355 SGTC_3175 9106517 49.47 µM 0.639086325583807 0.234393330282443 no 797 0.261383387578743 310 41468073 SGTC_202 3594-0513 34.79 µM 0.638139045756324 0.234696572898169 no 798 0.26169158572293 290 708429 SGTC_2740 felodipine 17.08 µM 0.637520229076776 0.234894785179707 no 799 0.261893018800936 266 3333 L-type calcium channel blocker SGTC_1573 oleylamine 1.06 µM 0.636392256792827 0.235256322248968 no 800 0.262260393265904 299 5356789 An amine of the fatty acid oleic acid. SGTC_1445 4239-0156 97.7 µM 0.629219858861691 0.237562388302183 no 801 0.264602564709542 308 4008346 SGTC_2286 7945697 125 µM 0.628856282527866 0.237679614644747 no 802 0.264721574562538 290 1245733 SGTC_3301 9125354 19.7965 µM 0.627633652798469 0.238074054557419 no 803 0.265121978905216 271 41905162 SGTC_942 3253-1115 227 µM 0.627350374324628 0.238165495889922 no 804 0.265214794880419 326 46497897 SGTC_422 cantharidin 155 µM 0.625851216757666 0.238649739138627 no 805 0.265706267258473 293 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3039 9090270 49.47 µM 0.625382814391393 0.238801148296356 no 806 0.26585991933754 270 17173750 SGTC_1415 3966-0071 78.1 µM 0.624752707836704 0.239004910535678 no 807 0.26606668695532 298 2893185 SGTC_3034 9090421 49.47 µM 0.62286067191853 0.239617323093613 no 808 0.266688042041666 278 17173761 SGTC_3232 9132874 49.47 µM 0.622823541459003 0.239629350012191 no 809 0.266700243225299 282 3784940 SGTC_176 1486-1328 72.834 µM 0.621441222445732 0.240077331025153 no 810 0.267154678221096 296 22310231 SGTC_2187 6125751 200 µM 0.620234590014608 0.240468748564919 no 811 0.267551675815154 297 874498 SGTC_230 MPP+ 141.667 µM 0.617222177997733 0.241447455104788 no 812 0.268544094617726 304 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2772 vinpocetine 57.06 µM 0.616822932914057 0.24157732855593 no 813 0.268675761948336 330 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.615855223193208 0.241892279502361 no 814 0.268995038187061 331 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2989 9073649 71.4286 µM 0.615835978866073 0.241898545022149 no 815 0.26900138939415 326 21367202 SGTC_3231 9132313 49.47 µM 0.6148947674862 0.242205089695102 no 816 0.26931210931184 301 4905967 SGTC_1230 0170-0365 3.77 µM 0.61257534445016 0.242961404396118 no 817 0.270078582493753 294 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_584 0986-0246 15.4 µM 0.607008411588042 0.244781864546875 no 818 0.27192266494534 326 53315 YDR232W HEM1 SGTC_2576 guaiol 23.12 µM 0.606911619438176 0.244813581664304 no 819 0.27195478328291 274 227829 SGTC_793 0488-0545 106 µM 0.606707057642821 0.244880620312149 no 820 0.27202266880492 307 292548 SGTC_1383 3049-0032 20.7 µM 0.606593718570635 0.244917767855287 no 821 0.272060284940058 319 712864 SGTC_3173 9105693 49.47 µM 0.60653418397276 0.24493728188228 no 822 0.272080044929809 313 17096658 SGTC_3024 9090631 49.47 µM 0.603818327126845 0.245828364168559 no 823 0.272982216670196 280 25236383 SGTC_110 0850-0284 111.64 µM 0.603073723634861 0.246072974811554 no 824 0.273229822912196 281 3906265 SGTC_1210 3013-0140 750 nM 0.602405088623364 0.246292740165155 no 825 0.273452261798834 291 905973 SGTC_2748 diazoxide 86.69 µM 0.60145555677912 0.24660501073801 no 826 0.273768302325322 263 3019 A potassium channel activatior. SGTC_1678 st019265 80.2 µM 0.600625050272983 0.246878311459548 no 827 0.274044874685788 314 5367020 SGTC_2957 9076800 11.52 µM 0.599387374933763 0.247285902774232 no 828 0.274457297005022 310 16459615 SGTC_3139 9095020 49.47 µM 0.598163954940951 0.247689152825955 no 829 0.274865269911705 265 25236292 SGTC_1500 4488-1866 171 µM 0.597843611593386 0.247794798812321 no 830 0.274972143913082 335 2900003 SGTC_3106 9121286 49.47 µM 0.597447481049532 0.247925471907848 no 831 0.275104330594442 274 15943471 SGTC_2275 7947463 200 µM 0.596567264382258 0.248215963943279 no 832 0.275398166255323 305 1225414 SGTC_2944 9067346 25.62 µM 0.596560928435736 0.248218055611205 no 833 0.275400281893108 316 6473075 SGTC_1457 k015-0032 57.3 µM 0.596300901318453 0.248303905728448 no 834 0.275487114522848 310 4302660 SGTC_1235 benzylparaben 21.5 µM 0.595973824877624 0.248411915213298 no 835 0.275596356510713 334 7180 SGTC_1720 st037298 9.481 µM 0.595879025893602 0.248443225081196 no 836 0.275628022905159 327 597396 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.595115222673206 0.248695567982089 no 837 0.275883226906263 310 2724278 An inhibitor of dopamine biosynthesis. SGTC_1856 st057054 55.7 µM 0.595094037828057 0.248702568909385 no 838 0.275890306898286 325 1266018 SGTC_1231 0242-0792 125 µM 0.594549200315128 0.248882656683883 no 839 0.276072422687333 316 3707635 SGTC_259 usnic acid 108.925 µM 0.593523535614699 0.2492218628283 no 840 0.276415418419633 339 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_457 grayanotoxin iii 135 µM 0.593168908194563 0.249339201796659 no 841 0.276534059085638 300 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_731 3966-0296 387 µM 0.593163037153851 0.249341144651191 no 842 0.276536023453398 298 660956 SGTC_1900 st060200 72.8 µM 0.593094089682169 0.249363961465097 no 843 0.276559092820892 298 688945 SGTC_11 0438-0307 1.3 µM 0.591611223264209 0.249854955543551 no 844 0.277055478317144 317 4011476 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.590181374148089 0.250328880550604 no 845 0.277534528998271 337 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1579 chlormadinone acetate 49.4 µM 0.589990036310114 0.250392335813957 no 846 0.277598664723647 334 45114258 A steroidal progestin. SGTC_1616 st002734 56.1 µM 0.589469859042239 0.250564890443996 no 847 0.277773062787053 308 4026101 SGTC_1738 st035555 74 µM 0.586702205490536 0.25148404237833 no 848 0.278701863143623 332 5331140 SGTC_2160 5660466 132.927 µM 0.58634533456093 0.251602690593121 no 849 0.278821735870623 322 2859134 SGTC_3026 9090633 49.47 µM 0.585613467128495 0.251846105671909 no 850 0.279067648158095 300 25236842 SGTC_1624 st003710 6.25 µM 0.584326400579459 0.252274478282216 no 851 0.279500366668236 335 24207033 SGTC_1574 spiramycin 23.7 µM 0.583793846542975 0.2524518398212 no 852 0.279679509371729 312 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2770 toltrazuril 17.5 µM 0.583601367197049 0.252515959213074 no 853 0.279744270067444 293 68591 Kills coccidiodes. SGTC_1245 0418-0076 17.2 µM 0.583391231903826 0.252585970012124 no 854 0.279814979506779 335 6790114 SGTC_46 0329-0187a 2.197 µM 0.576952301359077 0.254736176697974 no 855 0.281985838944132 322 46494817 SGTC_2759 disulfiram 3.38 µM 0.576803388835837 0.254786017459926 no 856 0.282036140020874 303 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_268 camptothecin 39.6153 µM 0.573344110103869 0.255945267252289 no 857 0.2832058622771 320 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2318 6029776 164 µM 0.572724730293035 0.256153119686694 no 858 0.283415545075502 335 818325 SGTC_623 k072-0108 16.9 µM 0.572720869608851 0.256154415537043 no 859 0.283416852292151 326 5382803 SGTC_2479 5617353 43.85 µM 0.571783383743946 0.256469186683684 no 860 0.283734367867778 336 2731746 SGTC_375 3970-0961 9.27 µM 0.570016770330645 0.257062893706792 no 861 0.284333161846644 303 2898222 SGTC_3340 9146634 11.102 µM 0.569791929095585 0.257138507505894 no 862 0.284409415132873 308 4907387 SGTC_2671 danthron 100 µM 0.569723077123384 0.257161664642604 no 863 0.284432767737618 312 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1346 1488-2224 62.4 µM 0.569048818962488 0.257388496678443 no 864 0.284661505073577 321 3722427 SGTC_2969 9091408 28.7 µM 0.567751306242002 0.25782529461305 no 865 0.285101924063027 317 4286311 SGTC_2522 biochanin a 4.94 µM 0.567454679669296 0.257925205723036 no 866 0.285202654590078 317 5280373 A possible chelator. SGTC_2426 5582046 32.21 µM 0.566212631165336 0.258343776184698 no 867 0.285624622193333 314 2251934 SGTC_617 3770-0098 35 µM 0.56605023494783 0.258398529733 no 868 0.285679815859455 317 5962639 SGTC_2866 9034245 58.44 µM 0.565915970889727 0.258443802775366 no 869 0.285725452069149 318 6462273 SGTC_2423 st077119 87.2 µM 0.564831242905822 0.258809717248158 no 870 0.286094277079259 296 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2238 6671620 73.2395 µM 0.564300886868745 0.258988721339828 no 871 0.286274688982345 287 729941 SGTC_3222 9128301 49.47 µM 0.563685697950206 0.259196438145542 no 872 0.28648402624418 302 4911358 SGTC_3157 9099274 49.47 µM 0.563457051494258 0.25927366192192 no 873 0.286561848859025 300 17217662 SGTC_1778 st046819 58.9 µM 0.562863651281684 0.259474134240792 no 874 0.286763866642832 333 671715 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.562735541818861 0.259517424813122 no 875 0.286807489220388 304 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_968 1309-0633 340 µM 0.562630048974119 0.259553075609222 no 876 0.286843412970171 320 3761976 SGTC_1567 st069303 68.4 µM 0.562090269375518 0.2597355310767 no 877 0.287027258867041 333 5581319 SGTC_3205 9113483 49.47 µM 0.561814730776846 0.259828693720761 no 878 0.287121127274547 349 17018033 SGTC_2661 dactinomycin 12.96 µM 0.561581744458562 0.259907482419039 no 879 0.287200510631983 313 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1921 5740136 50 µM 0.560689915903725 0.260209184821169 no 880 0.28750447140141 334 1774243 SGTC_1862 st057513 3.81 µM 0.559896863052538 0.260477623288792 no 881 0.287774894286347 317 5393163 SGTC_32 0928-0142 34.1 µM 0.559592477512595 0.260580691844041 no 882 0.287878718533417 324 2244242 SGTC_2265 7929201 200 µM 0.556964122764567 0.261471556513791 no 883 0.288775971015899 342 1265108 SGTC_2198 6589944 200 µM 0.556798110620355 0.26152787776925 no 884 0.288832687456167 295 5290268 SGTC_948 3448-0295 75.3 µM 0.553839430391329 0.262532682728564 no 885 0.289844370219172 313 678569 SGTC_2376 9072922 81.32 µM 0.553388203457164 0.262686098537551 no 886 0.289998807447506 316 17087968 SGTC_2782 7736369 71.43 µM 0.552817046016517 0.262880356112237 no 887 0.290194347474513 326 2950836 YOL077C BRX1 SGTC_2806 7952793 58.44 µM 0.552123446359973 0.263116356491282 no 888 0.290431889533127 320 2972490 SGTC_2137 5261020 140 µM 0.551720225834968 0.263253603818112 no 889 0.290570025190429 316 763655 SGTC_710 3448-4187 58 µM 0.551316648150803 0.263391009318595 no 890 0.290708313978242 305 3946412 SGTC_161 4065-0411 162.148 µM 0.550709698944582 0.263597725341483 no 891 0.290916347411774 325 1906281 YLR208W SEC13 SGTC_2493 resveratrol 26.09 µM 0.550642264737112 0.263620697332378 no 892 0.290939464957087 293 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_669 0108-0021 26.2 µM 0.548729119938201 0.264272850352636 no 893 0.291595679536897 356 17201 SGTC_1397 3532-0190 20.1 µM 0.548301724629425 0.264418653094871 no 894 0.29174237169727 304 5322280 SGTC_1142 3253-1408 9.78 µM 0.547776285238399 0.264597958940537 no 895 0.291922762014289 327 256655 SGTC_2862 9027634 71.43 µM 0.547326225542754 0.264751590679142 no 896 0.292077314770654 298 5012562 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.546582192239355 0.265005672264765 no 897 0.292332903031543 312 88881 An O-methylated flavonoid and antioxidant. SGTC_1615 st002656 86.5 µM 0.542807349668575 0.266296657574342 no 898 0.293631226160721 313 1584458 SGTC_3262 9137218 49.47 µM 0.542468912988625 0.266412557232141 no 899 0.293747758684346 289 17650664 SGTC_2541 muurolladie-3-one 83.07 µM 0.542405192442011 0.266434381567518 no 900 0.293769701714406 335 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2890 9046729 58.44 µM 0.541810340199062 0.266638162533454 no 901 0.293974583690046 315 903329 SGTC_1200 1643-0193 18.4 µM 0.540045252150144 0.267243299425375 no 902 0.294582912650376 339 5403974 SGTC_37 0566-0070 1.56 µM 0.538032282382378 0.267934264145436 no 903 0.295277380839911 330 1626686 SGTC_438 sphingosine 6.67 µM 0.537931674480986 0.2679688220416 no 904 0.295312110009611 298 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_974 1326-0144 138 µM 0.536059953155908 0.268612150248819 no 905 0.295958558093752 336 5411856 SGTC_2620 irigenin 100 µM 0.534787016274534 0.269050113615603 no 906 0.296398571097034 332 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1296 1068-0102 11.9 µM 0.533994078734639 0.269323110689406 no 907 0.296672815385701 338 767053 SGTC_2282 7944268 200 µM 0.533713522382931 0.269419735492989 no 908 0.296769876044006 323 2970414 SGTC_2421 5690543 90.72 µM 0.533662345557742 0.269437362883711 no 909 0.296787582633496 343 3397993 SGTC_958 1222-0007 33 µM 0.533377707154634 0.26953541453448 no 910 0.296886073051943 341 7312461 SGTC_2384 9036245 200 µM 0.532986280313045 0.269670281642995 no 911 0.297021538765799 298 6462766 SGTC_1606 st000094 49.2 µM 0.531815505504067 0.270073876724456 no 912 0.297426891286095 321 1242210 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.530144528890621 0.270650426717835 no 913 0.298005863812795 317 688667 SGTC_1239 0337-0584 35.4 µM 0.529552497522728 0.270854847253354 no 914 0.298211118452374 344 914301 YML130C ERO1 SGTC_1068 loratadine 26.9 µM 0.529274244455378 0.270950950939126 no 915 0.298307609788149 332 3957 A H1 histamine antagonist. SGTC_2781 5567276 71.43 µM 0.527993613435981 0.27139347745743 no 916 0.298751884335615 337 2853274 SGTC_418 lividomycin a 100 µM 0.527410159224723 0.271595211437788 no 917 0.298954395049298 321 72394 An antibiotic. SGTC_503 tyrphostin 8 294 µM 0.527107044384423 0.271700045293239 no 918 0.299059627570775 365 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_607 4491-0986 66.8 µM 0.526876548664148 0.27177977692567 no 919 0.299139660133308 315 698981 YDR232W HEM1 SGTC_3327 9140648 26.9345 µM 0.525754733567554 0.2721679943271 no 920 0.299529314702375 359 8029710 SGTC_409 arachidonic acid 100 µM 0.525277597823992 0.272333196311838 no 921 0.299695114142821 325 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1660 st012960 28.1 µM 0.524583197858046 0.272573712153811 no 922 0.299936484765407 342 24207266 SGTC_1219 1469-0211 33.1 µM 0.524220907088768 0.272699238841456 no 923 0.300062450487867 347 6822282 SGTC_1989 st071868 50.2 µM 0.523237395778802 0.273040150908426 no 924 0.300404530431475 340 16414057 SGTC_1672 st016598 6.51 µM 0.519092426015068 0.274479228636466 no 925 0.301848144886793 357 4665860 YNL267W PIK1 SGTC_2439 5492030 7.2 µM 0.519083642447366 0.27448228214258 no 926 0.301851207345041 326 5722370 SGTC_1874 staurosporine 7.6 µM 0.518128496057901 0.27481442776375 no 927 0.302184309737508 330 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2268 7933382 153.85 µM 0.516688919843646 0.275315404577426 no 928 0.302686666008746 316 935025 YOR257W CDC31 SGTC_220 paclitaxel 373.376 µM 0.514978586099535 0.275911189445143 no 929 0.303283991961815 331 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2337 9009472 200 µM 0.514668419317875 0.276019302052105 no 930 0.303392372658961 354 5742383 SGTC_541 4513-1321 94 µM 0.514092343845393 0.276220155723281 no 931 0.303593714979936 331 747515 SGTC_2097 5376186 200 µM 0.512001772141205 0.276949653415258 no 932 0.304324884651013 327 742755 SGTC_737 1950-0117 57.9 µM 0.510955212824208 0.277315200596898 no 933 0.304691209142933 324 5393513 SGTC_523 1934-0222 13.7 µM 0.510656545624832 0.277419563746064 no 934 0.304795786812926 379 1361595 SGTC_2555 cholic acid 100 µM 0.510320225928564 0.277537106769793 no 935 0.30491356751659 328 6708657 Influences liver metabolism. SGTC_442 cape 100 µM 0.509046453229371 0.277982508153887 no 936 0.305359831768023 330 5281787 SGTC_52 0329-0193 875 nM 0.508375390494382 0.278217299541121 no 937 0.305595053986822 367 3739292 SGTC_3195 9113082 49.47 µM 0.508303328113099 0.278242518470925 no 938 0.305620318206812 334 17018038 SGTC_298 1391-0729 10 µM 0.506624237342089 0.278830447916283 no 939 0.306209249397192 343 3237558 SGTC_1695 st026914 34.495 µM 0.506279097551631 0.278951372616767 no 940 0.306330367283955 323 3289191 SGTC_153 4077-0274 519.67 µM 0.506062840296969 0.279027154461172 no 941 0.306406267963177 328 3121976 SGTC_507 nimesulide 162 µM 0.504272038253102 0.279655079862282 no 942 0.307035111932288 339 4495 A COX2 inhibitor. SGTC_3291 9121177 71.43 µM 0.503481577487057 0.279932464405283 no 943 0.307312864744158 315 17015612 SGTC_316 k060-0003 58.6 µM 0.502789042755169 0.280175594827727 no 944 0.307556299088453 346 6152314 SGTC_1659 st012954 42.1 µM 0.502570898194909 0.280252200733352 no 945 0.307632997105328 330 24207262 SGTC_973 1325-0077 65.9 µM 0.501657147393919 0.280573193152761 no 946 0.307954356492316 349 2835149 SGTC_2112 5488546 200 µM 0.500173886766583 0.281094627717855 no 947 0.308476321886236 355 600757 SGTC_223 busulfan 5 mM 0.499906658066778 0.28118862068225 no 948 0.308570401951033 339 2478 A DNA alkylator. SGTC_3297 9117502 71.43 µM 0.498576284104057 0.281656781908884 no 949 0.309038958007225 308 7453720 SGTC_749 1000-0129 128 µM 0.497710616837803 0.281961613638988 no 950 0.309344011946276 346 708470 SGTC_1420 4'-methoxyflavone 42 µM 0.496912869237408 0.28224266910824 no 951 0.309625247958831 339 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1343 1487-0095 224 µM 0.495760334997888 0.282648957849799 no 952 0.310031756482467 372 4560101 YGL055W OLE1 SGTC_1791 st048313 56.1 µM 0.495357509612118 0.282791027196433 no 953 0.310173891199744 334 1204976 SGTC_865 0488-0499 301 µM 0.494348396248434 0.283147074051817 no 954 0.310530075779447 322 9634651 SGTC_2014 4013930 200 µM 0.494189993458575 0.28320298305151 no 955 0.310586003018287 355 64556 SGTC_976 1348-1067 47.6 µM 0.493334748772856 0.283504937084861 no 956 0.310888039682386 335 5310671 YGL099W LSG1 SGTC_593 1203-0218 61.7 µM 0.491269197326092 0.284234839567668 no 957 0.311618031430378 357 3666956 SGTC_351 caspofungin 25 nM 0.491170803153759 0.284269631453591 no 958 0.31165282367479 335 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1081 sertraline 6 µM 0.488252864703176 0.285302330028807 no 959 0.312685371860598 352 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2075 5212009 200 µM 0.487430658101115 0.285593642671234 no 960 0.312976585850505 367 780898 SGTC_406 estrone 100 µM 0.486199977755503 0.286029944300812 no 961 0.31341269356469 370 5870 A steroid. SGTC_1650 st011916 45.8 µM 0.486162181777235 0.286043348768391 no 962 0.313426091199002 368 242528 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.485823291849494 0.286163550527554 no 963 0.313546229351423 324 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1132 3456-3614 2.5 µM 0.485334593550339 0.286336930446304 no 964 0.313719510138993 344 3125502 SGTC_862 0452-0056 10.2 µM 0.484642951285717 0.286582395829652 no 965 0.313964820272279 337 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2292 7671323 168.05 µM 0.484053192664185 0.286791781289008 no 966 0.314174059507912 368 937504 SGTC_1837 st055472 66.5 µM 0.481869756756729 0.287567609853435 no 967 0.314949235771849 323 676091 SGTC_2679 rapamycin 1 nM 0.479727697079136 0.288329699231873 no 968 0.315710515388237 325 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_612 0302-0167 22.4 µM 0.479447320381577 0.28842952044139 no 969 0.315810218154499 369 235821 SGTC_2985 9022375 71.43 µM 0.478849429982174 0.288642438963393 no 970 0.31602287447231 339 4939335 SGTC_1851 st056236 18.9 µM 0.47831012477853 0.288834557825537 no 971 0.316214745575106 336 5393171 SGTC_2595 hexamethylquercetagetin 100 µM 0.477733210359499 0.289040140978902 no 972 0.316420051879899 380 386331 SGTC_2824 7998404 51.95 µM 0.477348476505693 0.289177278932181 no 973 0.316556998421158 363 837851 SGTC_3054 9094397 49.47 µM 0.475350690909913 0.289889878764893 no 974 0.317268516992819 362 2598354 SGTC_604 1000-0114 314 µM 0.475293390747751 0.289910329581633 no 975 0.317288934636211 352 1572745 SGTC_3176 9106582 49.47 µM 0.474884544263949 0.290056269299644 no 976 0.317434634159049 326 17018027 SGTC_1514 1189-1591 158 µM 0.474570671370156 0.290168331098857 no 977 0.317546507396286 373 767698 YMR146C TIF34 SGTC_3155 9099265 49.47 µM 0.474128952518618 0.29032607199648 no 978 0.31770397680132 376 25236499 SGTC_1540 guanosine 70.6 µM 0.473832282410513 0.290432037508581 no 979 0.31780975595083 363 6802 Guanosine is a purine nucleoside SGTC_3261 9137475 49.47 µM 0.470844429096932 0.291500255858623 no 980 0.318875917211663 332 17027690 SGTC_1048 3161-0300 24.5 µM 0.470780693771497 0.291523062482265 no 981 0.318898676383024 342 2165101 SGTC_1471 k673-0312 37 µM 0.469890694631108 0.291841620744122 no 982 0.319216556431428 332 24099884 SGTC_592 k241-0073 46.5 µM 0.46978199526767 0.291880538722994 no 983 0.319255389583198 347 4230158 SGTC_1241 0364-0022 50.8 µM 0.469351985236186 0.292034520273903 no 984 0.319409031306371 363 4563895 SGTC_2669 eugenol 100 µM 0.46843489756456 0.292363044883577 no 985 0.319736808465456 351 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1835 st008666 49.2 µM 0.46797433841992 0.292528093920762 no 986 0.319901470477452 335 690455 SGTC_3118 9124250 49.47 µM 0.464394501609377 0.293812461885645 no 987 0.321182564358917 366 1504786 SGTC_2786 7743617 45.45 µM 0.463665888852086 0.294074191563763 no 988 0.321443569950853 336 583674 SGTC_2269 7935389 174.42 µM 0.462898748739915 0.294349877305791 no 989 0.32171847222131 360 97605 SGTC_551 k048-0028 34.9 µM 0.462176656439694 0.294609483279647 no 990 0.321977320956462 354 6836383 SGTC_1298 1079-1278 263 µM 0.461490594256337 0.294856233548092 no 991 0.32222333400381 357 2840950 SGTC_3130 9127414 49.47 µM 0.454979673997719 0.29720268896303 no 992 0.324561930962594 334 1494646 SGTC_2886 9058944 51.95 µM 0.451095148627548 0.298606676700126 no 993 0.325960487032295 339 4949929 SGTC_2840 9008771 71.43 µM 0.450130069255213 0.298955953478891 no 994 0.326308328186899 321 2992978 SGTC_2880 9042983 58.44 µM 0.449863569178329 0.299052436561074 no 995 0.326404408787411 366 6464714 SGTC_597 k018-0003 82.8 µM 0.448830891646805 0.299426438250169 no 996 0.326776826168697 376 6786234 SGTC_884 0851-0618 334 µM 0.448415040145016 0.299577105800822 no 997 0.326926844636912 377 9642473 SGTC_198 3454-2873 16.191 µM 0.447098628637494 0.300054282459287 no 998 0.327401924573004 358 710957 SGTC_2011 4012611 177 µM 0.446619406709785 0.300228077540145 no 999 0.327574940520628 361 2049887 SGTC_85 0868-0259 160.055 µM 0.446274424514025 0.300353217277569 no 1000 0.327699514138306 367 83173 SGTC_1201 1889-3372 45.9 µM 0.446199309007837 0.300380467995814 no 1001 0.327726641009872 342 5392199 SGTC_2019 4016004 108 µM 0.445337582072482 0.300693168791532 no 1002 0.328037906162156 357 45595336 SGTC_8 0354-0001 70 µM 0.444124376840212 0.301133661779582 no 1003 0.328476331567519 363 4993152 SGTC_2955 9076254 12.21 µM 0.442025394209671 0.301896450443354 no 1004 0.329235414993375 351 16459619 SGTC_1902 st060212 70.5 µM 0.441917501249941 0.301935683139738 no 1005 0.329274452844149 353 688944 SGTC_2037 5169046 200 µM 0.44176176189264 0.301992318074153 no 1006 0.329330805769854 338 5718022 SGTC_859 0439-0102 54.6 µM 0.441021092944565 0.30226172912703 no 1007 0.329598863405033 376 610143 SGTC_66 0109-0187 42.4 µM 0.440614438027277 0.302409691703257 no 1008 0.329746074307141 332 759417 SGTC_938 3126-1755 342 µM 0.439851835710841 0.302687254313022 no 1009 0.330022210866829 350 1777771 SGTC_1920 st075728 45.7 µM 0.439493355512846 0.302817768948753 no 1010 0.330152047746344 392 3400306 SGTC_382 3229-0966 23.2 µM 0.439000903569045 0.302997100779288 no 1011 0.330330440806344 374 5722370 SGTC_2140 5586273 200 µM 0.438686729048757 0.303111535736597 no 1012 0.330444272176546 359 854421 SGTC_1932 st074806 40.9 µM 0.438397474868645 0.303216910796089 no 1013 0.330549088308815 411 17251235 SGTC_1655 st012546 55.1 µM 0.437338754601295 0.303602741329275 no 1014 0.330932846770588 376 720985 YLR208W SEC13 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.435724017632007 0.304191623302299 no 1015 0.331518488903538 349 77254 SGTC_417 st075190 100 µM 0.432763327655177 0.305272683375008 no 1016 0.332593358908088 400 222757 SGTC_111 0083-0039 52.457 µM 0.432658726102206 0.305310908523952 no 1017 0.332631359451059 389 759313 SGTC_761 k216-0224 480 µM 0.432655805621811 0.305311975802419 no 1018 0.332632420452728 401 1340404 SGTC_2584 androsterone 48.74 µM 0.430758629930046 0.306005640872599 no 1019 0.333321941598524 340 2754130 A steroid. SGTC_3230 9131665 49.47 µM 0.430278731416425 0.306181216790079 no 1020 0.333496448264852 369 15943720 SGTC_899 1083-0020 478 µM 0.42939097974698 0.306506127423587 no 1021 0.333819358537459 387 767123 SGTC_222 nsc-310342 10.666 µM 0.42787914220358 0.307059799056193 no 1022 0.334369556688209 396 432556 SGTC_3314 9135860 59.4275 µM 0.426628410587602 0.307518180201044 no 1023 0.334825000553094 367 25252478 SGTC_329 k048-0121 21.3 µM 0.423915325741809 0.308513532819839 no 1024 0.335813783381637 354 6832902 SGTC_514 4466-0038 2.65 nM 0.422922226743743 0.308878224861941 no 1025 0.336176002764418 333 5722064 SGTC_742 0kpi-0133 140 µM 0.422493705930081 0.309035647205205 no 1026 0.336332346928664 389 2728852 SGTC_1950 st077106 7.18 µM 0.420716242339454 0.309688994366761 no 1027 0.336981149625498 344 13831864 SGTC_2476 5806916 10.51 µM 0.420296670435848 0.309843305423124 no 1028 0.337134370964351 375 2870194 SGTC_2763 lisinopril 49.32 µM 0.419226814915726 0.310236930805077 no 1029 0.337525188330891 387 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_53 0973-0023 39.979 µM 0.417277414790804 0.310954720652791 no 1030 0.338237753160088 375 674768 SGTC_2937 9044753 11.33 µM 0.415082508210473 0.311763770142624 no 1031 0.339040751932378 359 6465530 YGL099W LSG1 SGTC_1717 st033143 58.0435 µM 0.414707030574366 0.311902263573893 no 1032 0.339178192493225 401 674616 SGTC_848 0368-0089 85.6 µM 0.414140686531303 0.312111207632785 no 1033 0.33938553864593 400 762535 SGTC_435 c-PAF 6.7 µM 0.411054543786223 0.313250854214452 no 1034 0.340516270125169 384 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_156 3474-0145 5.642 µM 0.40958887022481 0.313792722335841 no 1035 0.341053781340443 370 2265471 SGTC_1389 3405-0187 19 µM 0.408233978311738 0.314293991370766 no 1036 0.341550952368544 360 799890 SGTC_2803 7707263 71.43 µM 0.406614581986818 0.314893568570808 no 1037 0.34214554280324 370 2199229 SGTC_1712 st032288 53.4 µM 0.406351520638301 0.314991012473351 no 1038 0.342242167512522 366 2883011 SGTC_2085 5307070 144.047 µM 0.406075783634625 0.315093165551222 no 1039 0.342343459187373 397 2840351 SGTC_657 3534-0529 86.7 µM 0.406057970253266 0.315099765412093 no 1040 0.342350003302874 382 1049549 SGTC_2958 9077254 16.72 µM 0.406038763234253 0.315106881682089 no 1041 0.342357059453139 348 16457351 SGTC_603 3794-0023 45.9 µM 0.405927967300336 0.315147933315798 no 1042 0.342397764020083 371 3802260 SGTC_141 0443-0274 32.331 µM 0.405077662348491 0.315463060616872 no 1043 0.342710212698688 347 1627241 SGTC_2103 5378138 10 µM 0.404421382737471 0.315706372969341 no 1044 0.342951439433181 369 244142 SGTC_1915 st067105 30.6 µM 0.403928109216769 0.315889304237435 no 1045 0.343132792662847 377 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3168 9103419 49.47 µM 0.401605429657934 0.31675127918298 no 1046 0.343987216633738 389 16649256 SGTC_1742 st038235 28.8875 µM 0.401195784487984 0.31690340698214 no 1047 0.344137992074569 407 564103 YBR002C RER2 SGTC_2430 5571206 200 µM 0.400524066332338 0.317152926464394 no 1048 0.344385280644106 377 1731771 SGTC_2212 7123476 200 µM 0.396376631928727 0.318695389452559 no 1049 0.345913601190747 371 1085715 SGTC_1008 4106-0037 6 µM 0.395425855283998 0.319049434973359 no 1050 0.346264315412592 403 2905394 SGTC_838 0109-0203 71.4 µM 0.395227801815953 0.319123205940773 no 1051 0.346337388259732 356 759422 SGTC_702 1488-0190 94 µM 0.394072178650224 0.319553795295393 no 1052 0.346763875362727 366 949357 SGTC_904 1141-0088 396 µM 0.392783769487655 0.320034148139113 no 1053 0.347239596650077 372 1378119 SGTC_274 sirtinol 40.1 µM 0.392566244919942 0.320115276827595 no 1054 0.347319937357451 341 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1562 morin hydrate 59.1 µM 0.392478376411159 0.320148050999072 no 1055 0.347352392732259 369 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2751 anetholtrithion 17.25 µM 0.391146450901183 0.320645019092808 no 1056 0.347844493666611 386 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3260 9137109 49.47 µM 0.390962802710503 0.320713567165419 no 1057 0.347912365527261 383 17478346 SGTC_1714 st033236 13.627 µM 0.390087449495457 0.321040383346156 no 1058 0.348235941515975 372 2916566 SGTC_674 0498-0004 451 µM 0.389771667870516 0.321158315571041 no 1059 0.34835269793165 365 4231473 SGTC_2902 5787006 60.46 µM 0.389666381762141 0.321197639871265 no 1060 0.348391629385005 365 591003 SGTC_2188 6126565 140.678 µM 0.389183420967703 0.321378051133614 no 1061 0.348570233384373 372 874518 SGTC_2462 5162487 171.77 µM 0.387861863428503 0.32187193776836 no 1062 0.349059130836035 409 2259986 SGTC_338 4055-0136 114 µM 0.38716707911194 0.322131715822643 no 1063 0.34931626016362 359 2900563 SGTC_2463 5473429 200 µM 0.387104012647588 0.322155300514952 no 1064 0.349339603548967 392 5399405 SGTC_1929 genistein trimethyl ether 50.5 µM 0.386903818649188 0.322230170940995 no 1065 0.349413707017382 383 136420 SGTC_446 go6976 132 µM 0.386282806776307 0.322462468659045 no 1066 0.349643616219857 411 3501 A protein kinase C inhibitor. SGTC_383 2324-0395 7.37 µM 0.386000500928188 0.322568091829942 no 1067 0.349748148907883 380 3146421 SGTC_185 k048-0037 25.491 µM 0.385985440038762 0.322573727180838 no 1068 0.349753725999694 372 6827589 SGTC_3117 9124945 49.47 µM 0.38572394249069 0.322671578525815 no 1069 0.349850564481058 364 17592065 SGTC_2220 6782180 200 µM 0.384792855914844 0.323020087106642 no 1070 0.350195446258501 390 833803 SGTC_513 4245-1575 41.7 µM 0.383798933521398 0.323392286858131 no 1071 0.35056373928647 377 719745 SGTC_1511 0906-3109 28.5 µM 0.38294354869114 0.323712749243656 no 1072 0.350880810421072 362 2882180 SGTC_1365 1672-3266 55.4 µM 0.382634026686118 0.323828741163525 no 1073 0.350995568588657 407 6415873 SGTC_2685 mycophenolic acid 18.85 µM 0.381987551044546 0.324071060061649 no 1074 0.351235299286836 374 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1280 0880-0253 10.1 µM 0.381984546196679 0.324072186544944 no 1075 0.351236413704212 393 6836607 SGTC_1752 st044819 83.042 µM 0.381307574817712 0.324326016461837 no 1076 0.351487516798365 366 441209 YML126C ERG13 SGTC_748 act1.228 77.9 µM 0.380980909699096 0.324448528521548 no 1077 0.351608707038124 343 4421505 YNR035C ARC35 SGTC_2906 7926292 26.41 µM 0.38097860109431 0.32444939440531 no 1078 0.351609563566384 397 2966319 SGTC_3100 9120536 49.47 µM 0.380915105588205 0.324473209909326 no 1079 0.351633121681394 386 16421196 SGTC_1654 st012436 41.8 µM 0.380005430681463 0.324814483954631 no 1080 0.351970691959424 396 4323132 SGTC_29 0299-0004 12.984 µM 0.379213864495707 0.325111567980677 no 1081 0.352264528373763 383 16871 A napthoquinone isolated from Swertia calycina. SGTC_3159 9100096 49.47 µM 0.378935030696838 0.325216244057123 no 1082 0.352368054980227 358 25236875 SGTC_886 0866-0150 153 µM 0.378444611389166 0.325400384212968 no 1083 0.352550166495924 397 271463 SGTC_697 0508-1955 564 µM 0.378146133753254 0.325512475954587 no 1084 0.352661019249645 376 6243113 SGTC_2533 agelasine 13.65 µM 0.377102080498785 0.325904688891202 no 1085 0.353048872567694 396 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_87 0100-0052 35.5 µM 0.376990377012125 0.325946663259868 no 1086 0.353090378130307 378 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1188 1403-0014 4.57 µM 0.376540963345426 0.326115559906572 no 1087 0.353257384014209 370 9614867 SGTC_963 1269-2853 151 µM 0.374389209769671 0.326924716184962 no 1088 0.354057384784699 342 3668223 SGTC_166 k072-0058 166.424 µM 0.373072869933766 0.327420121063382 no 1089 0.354547105016297 391 5846229 SGTC_2122 5258151 111.688 µM 0.372066553090514 0.327799053846273 no 1090 0.354921649130177 371 2173356 SGTC_3339 9145883 14.936 µM 0.370837435676095 0.328262123733564 no 1091 0.35537930831173 391 2030670 SGTC_3042 9091578 49.47 µM 0.369242614544301 0.328863365936604 no 1092 0.355973447390377 376 25236497 SGTC_2142 5622915 118.518 µM 0.368557833904134 0.329121662015627 no 1093 0.356228664939648 370 5322196 SGTC_1626 st003712 1.76 µM 0.367130561247923 0.329660284805998 no 1094 0.356760815993742 395 24207035 SGTC_2551 apiole 73.87 µM 0.367041959642114 0.32969373285987 no 1095 0.356793859837781 391 10659 A possible DNA adduct former. SGTC_385 1494-0393 12.4 µM 0.361561722308468 0.33176521978473 no 1096 0.358839786607394 394 3090647 SGTC_378 3970-0959 8.33 µM 0.361501289673327 0.331788091695525 no 1097 0.358862370529179 400 6615653 SGTC_609 0986-0026 86.3 µM 0.361174029225883 0.331911960691261 no 1098 0.358984677659159 395 2848610 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.360869716315771 0.332027160467722 no 1099 0.359098421572662 395 688751 SGTC_967 1306-0166 352 µM 0.358996824811939 0.332736505861749 no 1100 0.359798732301088 401 4437607 SGTC_1091 telmisartan 47.6 µM 0.358038353384112 0.333099752592561 no 1101 0.360157305835306 395 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_685 1278-0033 54.9 µM 0.356528317991878 0.333672351740678 no 1102 0.360722474416838 417 3590572 SGTC_1866 st057638 64 µM 0.356471816194125 0.333693784519048 no 1103 0.360743627544489 404 688802 SGTC_2374 9071832 200 µM 0.355816968041889 0.333942227084162 no 1104 0.360988820486074 392 17381698 SGTC_3315 9136395 68.55 µM 0.35543125581293 0.334088596360711 no 1105 0.361133268369979 431 16876844 SGTC_2207 7258803 200 µM 0.355213042534989 0.334171414662304 no 1106 0.36121499725375 407 3666799 SGTC_2215 7188065 200 µM 0.355002084552529 0.334251487044 no 1107 0.361294014785815 410 940217 SGTC_964 1287-0107 19.4 µM 0.354110280134122 0.334590068584322 no 1108 0.361628119093028 390 51516812 YPR165W RHO1 SGTC_3084 9116877 49.47 µM 0.352874466350419 0.335059478753823 no 1109 0.362091276953989 404 27241325 SGTC_2667 digitoxin 100 µM 0.351431529262457 0.335607888563297 no 1110 0.362632316018175 384 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.351160298113373 0.335711013169451 no 1111 0.362734046650509 398 279621 SGTC_1685 st024049 53.0905 µM 0.35042595126257 0.335990280758003 no 1112 0.363009526643354 413 1941139 SGTC_2371 9071574 200 µM 0.349425881158261 0.336370746898407 no 1113 0.36338480301202 412 45596039 SGTC_1922 5578187 25 µM 0.349341210542667 0.336402966644525 no 1114 0.36341658169294 386 1350412 SGTC_1882 5615643 20 µM 0.349131616003624 0.336482728913017 no 1115 0.363495251019416 387 2253075 SGTC_502 l-744,832 89.3 µM 0.348152573168629 0.336855406064924 no 1116 0.363862801684032 427 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2519 cryptotanshinone 88.04 µM 0.347017232388923 0.337287779386587 no 1117 0.364289186353391 376 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2557 derrustone 83.84 µM 0.345662891180265 0.337803836088693 no 1118 0.364798037790849 400 629853 An antioxidant. SGTC_2629 bisabolol 100 µM 0.344869441782165 0.338106312965618 no 1119 0.365096262377237 427 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2835 9006588 71.43 µM 0.344615642305552 0.338203087870063 no 1120 0.365191672267763 334 2345538 SGTC_1092 toremifene 6.32 µM 0.343090626350527 0.338784808367749 no 1121 0.365765141361009 421 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_425 3825-7017 13.1 µM 0.342399717948957 0.339048483533611 no 1122 0.366025050363276 441 3397440 SGTC_1323 1348-1351 11.2 µM 0.342034983523081 0.339187710947404 no 1123 0.366162282592247 420 6989654 SGTC_529 4076-0302 30.3 µM 0.341916105150775 0.339233094268231 no 1124 0.36620701457389 402 5816522 SGTC_100 0086-0128 49.5915 µM 0.341312007006235 0.33946375239797 no 1125 0.366434354881514 414 93297 SGTC_255 tunicamycin 200.472 nM 0.34113388053861 0.339531776538804 no 1126 0.366501398183387 383 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2099 5377090 177.372 µM 0.340047847776739 0.3399466311193 no 1127 0.366910247644473 400 2243829 SGTC_2121 5257820 149.641 µM 0.340025746107674 0.339955075769434 no 1128 0.366918569640092 392 791256 SGTC_3038 9091290 49.47 µM 0.339777195306365 0.340050048087692 no 1129 0.367012161387988 430 25236843 SGTC_2914 7968218 45.32 µM 0.339324082064095 0.340223210700424 no 1130 0.367182801412582 401 2977111 SGTC_2764 methyldopa 94.69 µM 0.339167140437612 0.340283195668739 no 1131 0.367241910909501 413 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_806 3966-4455 5.86 µM 0.337352920727639 0.340976905234353 no 1132 0.367925435179265 388 714982 SGTC_3107 9121808 49.47 µM 0.337022670722909 0.341103242035581 no 1133 0.368049905041438 358 662681 SGTC_2150 5556613 200 µM 0.336689373940976 0.34123076244204 no 1134 0.368175537268109 402 743190 SGTC_97 0535-0701 19.132 µM 0.335857994287766 0.341548929939897 no 1135 0.368488977282319 386 2832013 YGL099W LSG1 SGTC_453 enantio-paf c16 10 µM 0.335375572077665 0.341733603704996 no 1136 0.368670896336484 427 13871343 A lipid and platelet activating factor SGTC_3020 9089140 49.47 µM 0.334791107836537 0.341957390446717 no 1137 0.368891334370887 378 17217859 SGTC_519 k048-0011 62.8 µM 0.333000662951643 0.342643283016213 no 1138 0.369566891362913 377 6836379 SGTC_2469 5655019 90.81 µM 0.332837670341075 0.342705748853253 no 1139 0.36962841052752 423 2788239 SGTC_2981 9013952 38.96 µM 0.330120040412547 0.34374789506228 no 1140 0.370654630608631 353 2996344 SGTC_2756 carbadox 75.1 µM 0.32924471405946 0.344083815263268 no 1141 0.370985364135109 384 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1321 1326-2144 215 µM 0.328377676977086 0.34441667567214 no 1142 0.37131305962231 426 3513030 SGTC_866 0495-0101 262 µM 0.327463168769659 0.344767891127274 no 1143 0.371658797869029 405 635694 SGTC_2074 5212007 75.395 µM 0.326249431074374 0.34523423183692 no 1144 0.372117822455242 434 758611 SGTC_2254 7938975 95.19 µM 0.326096614515059 0.345292963492865 no 1145 0.372175629190097 395 2969277 SGTC_2879 9041815 71.43 µM 0.325721475873933 0.345437155507729 no 1146 0.372317547097848 397 4942971 SGTC_69 0096-0274 206.684 µM 0.322243988965104 0.346774862331063 no 1147 0.373633930975398 413 6741392 SGTC_1737 st035557 69.7 µM 0.320505432334461 0.347444362040626 no 1148 0.374292606492789 394 5716916 SGTC_1406 3909-7906 11.9 µM 0.320435607911329 0.347471260645483 no 1149 0.374319068093164 413 X1406 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.319157186653095 0.347963885122858 no 1150 0.374803660307195 434 688669 SGTC_1050 3232-1156 69.3 µM 0.319021104461049 0.34801633791448 no 1151 0.374855254626796 402 700529 SGTC_3243 9134147 49.47 µM 0.318476240224562 0.34822638460097 no 1152 0.375061857353356 413 24282180 SGTC_3221 9128209 49.47 µM 0.318040072704111 0.348394561959491 no 1153 0.37522727007985 398 16460723 SGTC_2553 4-methylesculetin 85.09 µM 0.317553829874418 0.348582082480949 no 1154 0.37541170047966 390 5319502 SGTC_3214 9129694 49.47 µM 0.316740871761574 0.348895684043364 no 1155 0.375720116568005 436 17158655 SGTC_2743 auranofin 4.32 µM 0.316277347501765 0.349074536451766 no 1156 0.375896001709105 397 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_251 melphalan 456.522 µM 0.315870151741312 0.349231681985505 no 1157 0.376050534174566 423 460612 A DNA alkylator. SGTC_1825 st052143 62.6 µM 0.315771820997471 0.349269633794199 no 1158 0.376087854076647 414 674173 SGTC_972 1319-0219 195 µM 0.314971206896172 0.349578695487545 no 1159 0.376391757786296 424 23903702 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.313710257769984 0.350065662844681 no 1160 0.376870554614992 410 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1206 3978-0017 132 µM 0.312719932218227 0.350448290767401 no 1161 0.377246725420912 418 3873677 SGTC_1744 st037937 38.9 µM 0.3120042839799 0.350724887282738 no 1162 0.377518633798715 375 1016152 SGTC_3010 9080089 71.4286 µM 0.310874125233807 0.351161852358904 no 1163 0.377948157796984 404 17027233 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.306349613510205 0.352913178063933 no 1164 0.379669233866558 388 6312947 SGTC_3308 9128332 17.569 µM 0.305001098214716 0.353435760130297 no 1165 0.380182657947219 420 17332805 YDL196W YDL196W SGTC_2088 5278280 127.392 µM 0.304227889740436 0.353735521734793 no 1166 0.380477139145001 386 791502 SGTC_1891 st059073 26.2 µM 0.303474340162592 0.354027749158658 no 1167 0.380764199792262 440 688754 SGTC_1871 st057448 67.3 µM 0.303255854080118 0.354112494411948 no 1168 0.380847443170969 438 691747 SGTC_1043 0916-0009 19.3 µM 0.301877260953992 0.354647382490068 no 1169 0.381372815347075 430 3101130 SGTC_182 3448-4371 550.524 µM 0.301145089908688 0.354931578289612 no 1170 0.381651929572217 384 3491403 SGTC_14 0354-0009 295 µM 0.300393843672753 0.355223262140857 no 1171 0.381938379510319 442 1713507 SGTC_1186 1319-0216 26 µM 0.30014444661178 0.355320113466629 no 1172 0.382033488827143 402 4565136 SGTC_1181 1222-0449 220 µM 0.298134581347291 0.35610096898569 no 1173 0.382800224452516 411 658318 SGTC_1428 4049-0204 61.7 µM 0.297362270210144 0.356401181445123 no 1174 0.383094972783772 425 X1428 SGTC_2296 7971656 126.45 µM 0.297228808755426 0.356453069550457 no 1175 0.383145914484438 408 666570 SGTC_1338 1486-1223 76 µM 0.296192190827445 0.356856183742238 no 1176 0.38354165612132 437 3444526 SGTC_1844 rapamycin 4 nM 0.294094328633718 0.357672477511468 no 1177 0.384342912228056 399 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1014 4130-3005 69.3 µM 0.293199690574356 0.358020786190979 no 1178 0.384684760294002 408 743608 SGTC_355 1311-2252 105 µM 0.29293605844607 0.358123448428708 no 1179 0.384785513271381 406 5338538 SGTC_691 1548-0686 185 µM 0.292172791780541 0.358420733547451 no 1180 0.385077256734485 432 46495133 SGTC_2436 5633522 8.09 µM 0.291723003619484 0.358595961969524 no 1181 0.38524920977002 407 5724242 SGTC_3312 9133330 71.43 µM 0.291156679787278 0.358816632685018 no 1182 0.385465746225791 430 17617324 SGTC_91 0417-1751 58.384 µM 0.289821757724815 0.359336977648278 no 1183 0.385976300830286 440 6795624 SGTC_3277 9138724 49.47 µM 0.289475970502119 0.359471806120587 no 1184 0.386108582942082 426 15943418 SGTC_2843 9000894 45.46 µM 0.289380556665977 0.35950901272117 no 1185 0.386145086170535 383 2242070 SGTC_1704 st028805 70.8 µM 0.289103663475994 0.359616994688604 no 1186 0.386251025101047 395 2876101 SGTC_1746 st038117 42 µM 0.288854061087725 0.359714343478595 no 1187 0.386346529879064 429 2898218 SGTC_1133 3473-0247 50 µM 0.288574193292915 0.359823507070105 no 1188 0.386453623227612 390 711311 SGTC_1009 4106-0057 9.87 µM 0.288271220375448 0.359941695801309 no 1189 0.38656956766109 442 2928005 SGTC_2690 usnic acid 100 µM 0.287771363344952 0.360136717641431 no 1190 0.38676087963054 428 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1398 3558-0053 112 µM 0.287293045915006 0.360323369781206 no 1191 0.386943973444335 422 4532369 SGTC_3023 9089636 49.47 µM 0.287041593684222 0.360421506462139 no 1192 0.38704023624554 405 17249241 SGTC_1322 1348-1070 12 µM 0.286980458276871 0.360445367755562 no 1193 0.387063641604203 424 6758089 SGTC_31 0508-1974 57.237 µM 0.286571255471807 0.360605094563352 no 1194 0.387220313244702 406 6810525 SGTC_2863 9028737 58.44 µM 0.284960560712748 0.361234043649257 no 1195 0.387837178851302 444 6460917 SGTC_1610 st001799 48.1 µM 0.284651675460656 0.361354701057298 no 1196 0.387955508463745 409 621897 SGTC_2583 asiatic acid 100 µM 0.284219146235242 0.361523679710161 no 1197 0.38812122183313 463 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1410 3909-8106 77.9 µM 0.283974256420933 0.361619364185704 no 1198 0.388215054623133 434 1039210 SGTC_2261 9010538 184.68 µM 0.283714040257028 0.361721046526239 no 1199 0.38831476705871 415 6457250 SGTC_2080 5212524 12.4 µM 0.283701424783533 0.361725976410087 no 1200 0.388319601379029 408 260183 SGTC_287 k060-0039 29.6 µM 0.282937733364806 0.362024455012008 no 1201 0.388612284421708 406 5861974 SGTC_1388 3346-4487 254 µM 0.282778582727234 0.362086667489369 no 1202 0.388673286519699 430 3345614 SGTC_768 0384-0033 77.3 µM 0.282732219859416 0.362104791563471 no 1203 0.388691057823929 415 3965305 YMR134W ERG29 SGTC_360 0957-0399 1.01 µM 0.282392284280102 0.362237687902089 no 1204 0.388821365302339 411 6752301 YPR165W RHO1 SGTC_3055 9094636 49.47 µM 0.282144423078581 0.362334598632271 no 1205 0.388916385803585 433 25236176 SGTC_2846 9008642 19.48 µM 0.281586116815116 0.362552921936972 no 1206 0.38913044339781 441 2992898 SGTC_2852 9023854 51.95 µM 0.278719066176302 0.363674772766182 no 1207 0.390230214713442 453 19798528 SGTC_1980 st071811 45.7 µM 0.278277550933403 0.363847637849724 no 1208 0.390399653776139 439 4974850 SGTC_511 blebbistatin 171 µM 0.277576051485443 0.364122350724222 no 1209 0.390668909051073 429 3476986 A myosin inhibitor. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.277272863001836 0.364241103415743 no 1210 0.390785297578492 404 4174840 SGTC_625 k213-0058 121 µM 0.276290943528837 0.364625790486034 no 1211 0.391162305658894 417 3655420 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.273921871350691 0.365554483757309 no 1212 0.392072331644212 438 551469 SGTC_485 niflumic acid 177 µM 0.271711342969281 0.366421738205406 no 1213 0.392921989444326 429 4488 A COX2 inhibitor. SGTC_368 fentichlor 4.58 µM 0.271230516902594 0.366610470766453 no 1214 0.393106871636275 435 7329 A pesticide. SGTC_849 0386-0493 241 µM 0.270675051684322 0.366828540642968 no 1215 0.39332048330682 425 726119 SGTC_1763 st044482 94.5 µM 0.269304182281094 0.367366913553538 no 1216 0.393847807019754 446 88505 SGTC_1482 3346-2049 8.48 µM 0.269052528555066 0.367465772303176 no 1217 0.393944630256096 425 3826804 SGTC_1284 0929-0043 16 µM 0.268817855956629 0.367557968162607 no 1218 0.394034925947085 430 1239883 SGTC_628 1636-0253 16 µM 0.268645983103551 0.367625496719695 no 1219 0.394101061602688 430 4456143 SGTC_2718 lomofungin 53.02 µM 0.26857657605773 0.367652767792389 no 1220 0.394127769888412 431 5351222 A RNA synthesis inhibitor. SGTC_1156 4092-0367 4.88 µM 0.267922239210029 0.367909899369486 no 1221 0.39437958744774 445 1357585 SGTC_246 cycloheximide 667 µM 0.26663551527643 0.368415709615275 no 1222 0.394874904013233 429 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3087 9117406 49.47 µM 0.265954531836186 0.36868349608156 no 1223 0.395137113281317 377 42546093 SGTC_145 3737-0113 38.366 µM 0.264480603117858 0.369263314572897 no 1224 0.395704804655552 433 6849351 SGTC_3283 9109332 35.8195 µM 0.263479483345797 0.369657307836259 no 1225 0.396090517482483 418 17027281 SGTC_159 3970-0959 50 µM 0.261023166950635 0.370624576697496 no 1226 0.397037320874533 421 6615653 SGTC_3351 9150312 21.596 µM 0.259574222352927 0.371195538412736 no 1227 0.397596111240562 448 4904905 SGTC_2589 lobaric acid 100 µM 0.259012733729398 0.371416871297399 no 1228 0.397812707792148 401 73157 A novel microtubule depolymerizer. SGTC_9 0092-0002 10.449 µM 0.25813046354821 0.37176473876627 no 1229 0.398153110767596 425 759368 SGTC_756 0508-1999 28.3 µM 0.257898048073738 0.371856394554925 no 1230 0.398242795665701 414 6753853 SGTC_2044 5102272 200 µM 0.257511252505677 0.372008948057489 no 1231 0.398392064945698 422 592666 SGTC_460 trequinsin 123 µM 0.257326485203564 0.372081828010465 no 1232 0.398463374222999 436 5537 A vasodilator. SGTC_2012 4023501 200 µM 0.257090172250556 0.372175046402991 no 1233 0.398554582021296 444 3477460 SGTC_2429 5902844 64.44 µM 0.254828969853687 0.373067401191778 no 1234 0.399427599521336 441 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1361 1608-0041 5.61 µM 0.254636779934735 0.373143277985785 no 1235 0.399501824526551 440 X1361 SGTC_1568 digitonin 820 nM 0.254563715041417 0.373172125378021 no 1236 0.399530043619941 447 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1706 st031321 9.9705 µM 0.253642735977577 0.373535806124171 no 1237 0.399885788737722 418 6103185 SGTC_1492 4158-0558 28.5 µM 0.253095850977074 0.373751816097819 no 1238 0.400097072484021 448 3967268 SGTC_1618 st003135 44.5 µM 0.253046297718387 0.37377139072571 no 1239 0.400116218353639 456 1270615 SGTC_167 3672-0051 66.205 µM 0.247992594144202 0.375769416439217 no 1240 0.402070068438594 440 3237971 SGTC_2670 beta-carotene 100 µM 0.247360879582371 0.37601940592602 no 1241 0.40231447356869 421 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1749 st037932 54.2 µM 0.247079687280933 0.376130699380561 no 1242 0.402423276830241 443 594497 SGTC_2223 6903751 107.57 µM 0.247070338036535 0.376134399906763 no 1243 0.402426894513954 438 5598863 SGTC_1756 st041558 35.5 µM 0.246872193801301 0.376212830091977 no 1244 0.402503568254841 432 3955792 SGTC_56 0957-0365 83.25 µM 0.246685132023787 0.376286878269116 no 1245 0.402575956978343 442 6752360 SGTC_1151 3909-8316 15.3 µM 0.246168452506867 0.376491428879623 no 1246 0.402775917742236 434 800431 SGTC_1993 st073995 70.8 µM 0.246098423748967 0.376519155554529 no 1247 0.402803021614801 424 3098394 SGTC_1976 st070609 63.5 µM 0.244916866930064 0.376987068482627 no 1248 0.403260400718746 463 682556 SGTC_2208 7283366 200 µM 0.243519352258285 0.377540736965104 no 1249 0.4038015476594 443 898663 SGTC_2724 maprotiline 69.64 µM 0.241928554379165 0.378171286888764 no 1250 0.404417762018729 448 4011 A tricyclic antidepressant. SGTC_1352 1496-0991 99 µM 0.241047209124839 0.378520768541725 no 1251 0.40475926372524 471 3000039 SGTC_810 3825-7150 143 µM 0.239824462657243 0.379005791253911 no 1252 0.405233170925755 417 22330411 YGL099W LSG1 SGTC_565 1418-0001 44.5 µM 0.239605005381009 0.379092862823406 no 1253 0.405318242032806 416 2862145 SGTC_3225 9130819 49.47 µM 0.238830703262237 0.379400122856753 no 1254 0.405618430644902 445 4547121 SGTC_577 r071-0003 38.6 µM 0.235784390331559 0.380609704334567 no 1255 0.40679999070506 440 4568517 YMR134W ERG29 SGTC_501 nsc-95397 161 µM 0.235408152124369 0.380759176294127 no 1256 0.406945979684018 451 262093 SGTC_1103 duloxetine 36.1 µM 0.234652195411901 0.381059556655428 no 1257 0.407239347148701 436 60835 A selective serotonin reuptake inhibitor. SGTC_440 fluspirilene 35.1 µM 0.234193431621963 0.381241881994889 no 1258 0.407417407027147 440 3396 An atypical antipsychotic. SGTC_2796 7949634 45.45 µM 0.233816085238916 0.381391869581343 no 1259 0.407563880728771 428 2971588 SGTC_1213 1315-0166 115 µM 0.233041883130566 0.381699655073993 no 1260 0.407864441467546 406 768401 SGTC_808 0711-0032 135 µM 0.231278090948173 0.382401133015525 no 1261 0.40854938310481 454 4252555 SGTC_140 0062-0056 502.533 µM 0.23108510027257 0.38247791082865 no 1262 0.408624345071571 401 3758964 SGTC_412 gemfibrozil 100 µM 0.23060137103914 0.382670373959538 no 1263 0.408812251190922 450 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1594 piperine 70.1 µM 0.23034338394676 0.382773032086186 no 1264 0.408912475649847 464 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_379 3970-0972 5.9 µM 0.230138060378297 0.382854740249594 no 1265 0.408992245306333 422 2898042 YBL034C STU1 SGTC_3078 9116413 49.47 µM 0.229941626427271 0.38293291568484 no 1266 0.409068564811863 447 17177322 SGTC_3110 9122132 49.47 µM 0.229868616632683 0.382961972837453 no 1267 0.409096931822954 423 918317 SGTC_3203 9113543 49.47 µM 0.229487526892505 0.383113653349903 no 1268 0.409245007035663 410 17018012 SGTC_581 0958-0271 211 µM 0.228630977124376 0.383454640813289 no 1269 0.409577872963512 417 4591145 SGTC_489 paxilline 115 µM 0.228536526697861 0.383492246508693 no 1270 0.409614581572701 437 105008 A toxic potassium channel blocker. SGTC_2400 5203494 178.7 µM 0.227180695637594 0.384032195151942 no 1271 0.410141618962679 432 6777674 SGTC_2068 5226020 147 µM 0.225702057510654 0.38462130738064 no 1272 0.410716578857648 436 1810509 SGTC_1561 5-methoxyflavone 52.9 µM 0.223936908596528 0.385324918844285 no 1273 0.411403198013333 465 94525 SGTC_3319 9138450 16.7555 µM 0.223633189432647 0.385446023422579 no 1274 0.411521368107257 456 2029690 SGTC_1250 0485-0349 40.2 µM 0.223031918628507 0.385685806284702 no 1275 0.411755332318427 441 6842794 YDL195W SEC31 SGTC_3065 9113888 49.47 µM 0.222555812161681 0.385875705428705 no 1276 0.411940615321697 438 16648368 SGTC_129 0088-0017 176.636 µM 0.221095268853923 0.386458426114584 no 1277 0.412509127009021 459 182446 SGTC_2466 5983409 37.09 µM 0.218929503500374 0.387322984163635 no 1278 0.413352481723423 454 2879657 SGTC_2769 toremifene 3.73 µM 0.218063468487648 0.387668855896766 no 1279 0.413689830188792 444 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_644 1498-1197 63.3 µM 0.218005637186569 0.387691955384461 no 1280 0.413712359610891 439 6741615 SGTC_3342 9147791 14.508 µM 0.217607727226853 0.387850902858371 no 1281 0.413867381655939 453 1838168 SGTC_2125 5246583 200 µM 0.21641859724055 0.388326019728216 no 1282 0.414330735622742 463 835267 SGTC_2833 9001315 45.46 µM 0.212844185942897 0.389755179476039 no 1283 0.415724248950938 414 2989378 SGTC_3060 1327-0027 12.5 µM 0.211642657843158 0.390235923430284 no 1284 0.416192913477068 456 16000455 YPR107C YTH1 SGTC_1728 st035614 33.7865 µM 0.210947154367225 0.390514278415279 no 1285 0.416464254030848 435 15945546 SGTC_2657 nystatin 74.44 µM 0.21072771337271 0.3906021149287 no 1286 0.416549874007823 432 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_934 2950-0684 338 µM 0.209612275734134 0.391048681784463 no 1287 0.41698514891926 474 1121253 SGTC_2860 9025725 38.96 µM 0.208524284577174 0.391484398847597 no 1288 0.417409811508667 473 40546248 SGTC_1849 st056239 19.2 µM 0.208489704475401 0.391498249670663 no 1289 0.417423310329106 463 5393181 SGTC_815 1582-0027 36.9 µM 0.207470738503627 0.391906451194963 no 1290 0.41782112139273 457 3128206 SGTC_323 4013-0906 34.3 µM 0.206003638715527 0.3924943857152 no 1291 0.418394034492047 462 2910086 SGTC_1953 st076800 12.1 µM 0.204624301061562 0.39304737379611 no 1292 0.418932833810599 431 297591 SGTC_1171 0368-0077 21.4 µM 0.200588419805448 0.394666628756168 no 1293 0.420510206847111 442 3239779 SGTC_148 3253-0744 288.01 µM 0.200407079328165 0.394739428192183 no 1294 0.420581111648079 461 6893655 SGTC_626 0214-0009 33 µM 0.199467152335704 0.395116822292345 no 1295 0.420948667840299 458 3437874 SGTC_3184 9108758 49.47 µM 0.198112058828191 0.395661084802041 no 1296 0.421478695121842 461 902885 SGTC_2709 st078560 56 µM 0.197869003552208 0.395758727574283 no 1297 0.421573778125217 459 17250903 SGTC_1000 4048-0884 8.67 µM 0.19783210676681 0.39577355071874 no 1298 0.421588212514098 456 13040088 SGTC_661 1304-0007 33.6 µM 0.197156492793061 0.396045002717119 no 1299 0.421852538019187 454 3117130 SGTC_2218 6965428 192.983 µM 0.196825796505841 0.396177890125952 no 1300 0.421981931642215 441 675684 SGTC_2827 7993847 71.43 µM 0.196691768008115 0.396231751741366 no 1301 0.422034376217538 468 2985692 SGTC_2815 7968870 71.43 µM 0.195758432658314 0.396606883185186 no 1302 0.422399623224056 452 2977326 YHR190W ERG9 SGTC_3132 9126706 49.47 µM 0.195551418991804 0.396690100275617 no 1303 0.422480644019286 481 850858 SGTC_1800 st050079 29.0735 µM 0.195412443327339 0.396745969519279 no 1304 0.422535038011761 463 3645560 SGTC_2164 5685496 200 µM 0.195252735985042 0.396810175668049 no 1305 0.422597548045596 418 759046 SGTC_1047 2043-3044 82 µM 0.195089527553519 0.396875792228159 no 1306 0.422661430432324 471 669592 SGTC_1510 1123-0200 71.5 µM 0.193517824145625 0.397507831385724 no 1307 0.423276724118239 457 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1984 st072354 53.1 µM 0.193223739800705 0.39762612335147 no 1308 0.423391873694612 462 5762938 SGTC_258 haloperidol 50.781 µM 0.193048718922706 0.397696527908578 no 1309 0.423460406732482 486 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1843 st055809 45.5 µM 0.192061298553106 0.398093793710757 no 1310 0.423847094887468 439 16413835 SGTC_3057 9095946 49.47 µM 0.191426712622425 0.398349160520078 no 1311 0.424095646688165 462 24540043 SGTC_44 0929-0055 61.211 µM 0.190593537745937 0.39868450856624 no 1312 0.424422026758061 459 1379590 SGTC_982 1491-0518 27.5 µM 0.190364599690576 0.398776667916931 no 1313 0.424511717880368 436 3091256 SGTC_1968 st069590 43.6 µM 0.189721510186013 0.399035574721176 no 1314 0.424763682122656 472 6384066 SGTC_3119 9125183 49.47 µM 0.18920777622812 0.399242435115568 no 1315 0.424964986599184 469 22695334 SGTC_2397 5161689 200 µM 0.18869554908039 0.399448716948541 no 1316 0.425165720120811 454 2259942 SGTC_2911 7942208 15.64 µM 0.188539253807369 0.39951166507674 no 1317 0.425226973572242 440 1243384 SGTC_1699 st031318 29.054 µM 0.188066407545835 0.399702120434868 no 1318 0.425412297042657 472 5340658 SGTC_2139 5578692 56.4705 µM 0.188060608480497 0.399704456359349 no 1319 0.42541456998296 457 650991 YMR113W FOL3 SGTC_1931 st074438 57.1 µM 0.188006508600806 0.399726248532556 no 1320 0.42543577451892 481 2787313 SGTC_971 1315-0384 26.7 µM 0.187467243379805 0.399943489020214 no 1321 0.425647152180506 465 6769120 SGTC_990 3985-0011 41.3 µM 0.187056353418374 0.400109034923949 no 1322 0.425808224493688 469 5399565 YGL099W LSG1 SGTC_328 k915-0120 63.5 µM 0.185184240949042 0.400863528271624 no 1323 0.426542264607663 440 6624543 SGTC_2455 5377712 9.75 µM 0.184365960251317 0.401193425746534 no 1324 0.426863185916715 440 2243908 SGTC_1798 st045719 60.953 µM 0.183384260142015 0.401589300227559 no 1325 0.427248262516108 481 3980186 SGTC_3247 9135149 49.47 µM 0.181020249997074 0.402543010527079 no 1326 0.428175840694908 480 8934436 YOR116C RPO31 SGTC_2687 chenodiol 100 µM 0.180168072464493 0.402886946273379 no 1327 0.428510311363594 448 5702181 A cholesterol synthesis inhibitor. SGTC_3209 9113616 49.47 µM 0.179011612192187 0.403353809584559 no 1328 0.428964291882197 472 16649353 SGTC_2328 6201408 200 µM 0.178939197861146 0.403383047859208 no 1329 0.428992722014837 451 2890418 SGTC_204 PMA1.184 62.41 µM 0.178880240171582 0.403406853230032 no 1330 0.429015869292626 452 2252213 YGL008C PMA1 SGTC_1371 2421-0008 32.7 µM 0.178353975369529 0.403619359234015 no 1331 0.429222496023304 467 2827552 SGTC_2898 9056270 58.44 µM 0.177508516950423 0.403960815344238 no 1332 0.429554487953455 469 19154699 SGTC_2575 plumbagin 510 nM 0.176733222079025 0.404273998776792 no 1333 0.429858972086492 476 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_114 0364-0001 490.298 µM 0.176203218462502 0.404488131157654 no 1334 0.430067146190739 424 4003655 SGTC_3102 9121669 49.47 µM 0.175394309769341 0.404815002075472 no 1335 0.430384905715256 479 41905072 SGTC_684 1140-0066 328 µM 0.174456454111084 0.405194062159551 no 1336 0.430753375252519 448 6813534 SGTC_2319 6033012 152.6 µM 0.174423637493885 0.405207327508172 no 1337 0.430766269506844 450 847246 SGTC_1070 indatraline 8.81 µM 0.174367668879319 0.40522995176053 no 1338 0.430788260778335 478 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2701 st077767 14.721 µM 0.174166581598391 0.40531124009759 no 1339 0.430867274062867 439 5721188 SGTC_197 4544-0043 41.561 µM 0.173658336278498 0.405516713446129 no 1340 0.431066991375298 461 896523 SGTC_2610 ononetin 44.17 µM 0.173086116678055 0.405748081467884 no 1341 0.431291868766046 452 259632 SGTC_2127 5253358 187.912 µM 0.172950349974091 0.405802981441823 no 1342 0.43134522718718 461 20612 SGTC_1726 st035556 14.5795 µM 0.172917442874228 0.405816288362813 no 1343 0.431358160376674 417 5919439 SGTC_1335 1486-0900 202 µM 0.172109344883836 0.406143099863945 no 1344 0.43167578311825 469 X1335 SGTC_830 4076-0286 57.8 µM 0.171859327648875 0.406244225251756 no 1345 0.431774061296744 455 6866659 SGTC_2171 5739187 198.077 µM 0.167712861090298 0.40792226891148 no 1346 0.433404588910794 472 2262761 SGTC_653 0203-0016 55.2 µM 0.16682852410302 0.408280373154814 no 1347 0.433752487104498 476 295302 SGTC_2441 5730946 39.09 µM 0.164997468210765 0.409022085856501 no 1348 0.434472987410062 443 1774275 SGTC_819 1013-0258 27.7 µM 0.164133697065838 0.409372090173681 no 1349 0.434812947550324 451 5753198 SGTC_1111 tnp00062 510.699 nM 0.163556654594808 0.409605950896764 no 1350 0.435040084855425 460 676306 SGTC_1356 1502-0781 85.8 µM 0.163477258624249 0.409638130595325 no 1351 0.435071338631002 447 567702 SGTC_3 0833-0587 95.581 µM 0.162272483733019 0.410126508205343 no 1352 0.435545641135039 455 5382644 SGTC_2348 9022543 33.42 µM 0.161064613374935 0.410616280595223 no 1353 0.436021255372933 487 3162678 YDL140C RPO21 SGTC_2355 9061122 103.12 µM 0.161009383495273 0.410638678779621 no 1354 0.436043005054445 477 5302957 SGTC_1444 4112-3581 28 µM 0.158876041311593 0.411504066727717 no 1355 0.436883268590187 466 2877249 SGTC_1855 st056195 39.6 µM 0.158646471742035 0.411597217117297 no 1356 0.436973706633797 474 4028379 SGTC_2030 5175110 200 µM 0.158605560089855 0.411613817995514 no 1357 0.436989823966803 482 2831986 SGTC_500 h-89 112 µM 0.157623785716054 0.412012243744118 no 1358 0.437376629791748 471 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1303 1160-0052 261 µM 0.156881932278377 0.412313364467533 no 1359 0.437668949739505 487 3562476 SGTC_1630 st005209 31.3 µM 0.155882552263094 0.412719097655079 no 1360 0.438062799227183 485 3367314 SGTC_2021 4019055 173 µM 0.155054946035115 0.413055163900895 no 1361 0.43838900019077 480 44827708 YER133W GLC7 SGTC_2235 salicylic acid 500 µM 0.154319672568271 0.413353790027579 no 1362 0.438678843323998 465 338 A COX inhibitor and kinase inhibitor. SGTC_481 bay k-8644 50 µM 0.153071191928843 0.413860966367155 no 1363 0.43917106681481 475 2303 A calcium channel antagonist. SGTC_477 mead ethanolamide 10 µM 0.153044214488378 0.413871927132798 no 1364 0.439181703927835 460 16061185 SGTC_3320 9137005 35.139 µM 0.152828175990254 0.413959704645329 no 1365 0.439266888756346 491 4908713 SGTC_3245 9134821 49.47 µM 0.152674030194226 0.414022337474314 no 1366 0.439327670768841 461 17014901 SGTC_1935 st074532 41.6 µM 0.15135248796382 0.414559398750215 no 1367 0.439848833361022 500 2829742 SGTC_672 1441-0018 53.7 µM 0.15128830045586 0.414585487974767 no 1368 0.439874148969654 451 251141 SGTC_2003 4023581 200 µM 0.15043224912318 0.414933468844564 no 1369 0.440211799817868 468 16641307 SGTC_1996 st072960 66.8 µM 0.149016339639661 0.415509175832003 no 1370 0.440770369876371 470 1719405 SGTC_2648 atorvastatin 78.68 µM 0.147729528711774 0.416032548912057 no 1371 0.441278113388731 494 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1675 st018485 24.5 µM 0.146013404940145 0.416730764186055 no 1372 0.441955403115564 497 3323024 SGTC_2935 9038016 29.96 µM 0.145410160368868 0.416976260397838 no 1373 0.442193521555218 499 6463195 SGTC_462 ag-879 158 µM 0.143852387629208 0.417610360609253 no 1374 0.442808516848248 497 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_622 1348-1566 26.3 µM 0.142959627636439 0.417973860323483 no 1375 0.443161033046052 475 7340407 SGTC_132 0417-1715 25.805 µM 0.142357993201143 0.418218863744989 no 1376 0.443398620478997 500 6769098 SGTC_1462 k081-0014 26.5 µM 0.142345404169322 0.418223990712182 no 1377 0.44340359214705 476 3270634 SGTC_187 1488-2104 32.728 µM 0.139474650651906 0.419393485418037 no 1378 0.444537542991421 495 2852859 SGTC_1782 st039423 80.636 µM 0.139021863209867 0.419578008401602 no 1379 0.444716436233041 477 2068169 SGTC_1581 himbacine 57.9 µM 0.137836874331207 0.420061006646379 no 1380 0.445184670496098 476 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3271 9137798 49.47 µM 0.136961434833708 0.420417910790781 no 1381 0.445530639163646 489 6498326 SGTC_3298 9116858 71.43 µM 0.13625292991382 0.420706806024509 no 1382 0.445810666628838 481 2506942 SGTC_1716 st033144 30.6155 µM 0.134964025764538 0.421232470390946 no 1383 0.446320158658386 498 674617 SGTC_188 3229-0966 278.469 µM 0.134358676504884 0.421479403476309 no 1384 0.446559478329006 491 5722370 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.132193514933909 0.422362864776351 no 1385 0.44741561521968 475 803109 SGTC_445 e6 berbamine 66 µM 0.132127168870708 0.422389942472519 no 1386 0.447441853323902 485 6610268 A calcium/calmodulin antagonist. SGTC_1665 st014639 11.4 µM 0.131831310910513 0.422510694898046 no 1387 0.447558860080084 492 981133 YIL048W NEO1 SGTC_3267 9137951 49.47 µM 0.131821870375632 0.422514548108469 no 1388 0.447562593725133 491 16643986 SGTC_1164 k060-0068 93.7 µM 0.131815875673362 0.42251699488568 no 1389 0.447564964577368 497 5963676 SGTC_829 1635-0120 117 µM 0.131781683388338 0.42253095074915 no 1390 0.44757848736239 485 285054 SGTC_1941 st076221 61.8 µM 0.131300113832852 0.422727517661715 no 1391 0.447768950872824 457 2828568 SGTC_1382 3002-2117 298 µM 0.130348811271921 0.42311587655283 no 1392 0.448145231822883 495 1497314 SGTC_2361 9034121 116 µM 0.130231541000446 0.423163756042468 no 1393 0.448191620480649 474 6496917 SGTC_2117 5521686 200 µM 0.129907997511642 0.423295859317658 no 1394 0.448319608406111 473 803312 SGTC_3148 9097893 49.47 µM 0.129808836338436 0.423336348695507 no 1395 0.448358835842141 484 17174100 SGTC_1112 tnp00069 1.16933 µM 0.129697706259768 0.423381726165344 no 1396 0.448402798689792 504 145826 SGTC_2939 9044578 71.43 µM 0.129474182034059 0.423473000336098 no 1397 0.448491226366617 473 2653634 SGTC_2390 9097792 176.6 µM 0.128514207106652 0.423865044368606 no 1398 0.448871027903435 442 4497149 SGTC_1498 4478-3555 97.6 µM 0.128147514519456 0.424014817818927 no 1399 0.449016117421274 499 3437919 SGTC_2697 mebhydrolin 72.4 µM 0.127570375684131 0.424250569036643 no 1400 0.449244488159129 485 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_585 0kpi-0023 191 µM 0.127403234506642 0.424318848378072 no 1401 0.449310628168709 489 64601 SGTC_3293 9120939 62.045 µM 0.12706034760797 0.424458929236233 no 1402 0.449446317527819 490 934087 SGTC_2172 5754775 163.918 µM 0.126964274749099 0.424498179950187 no 1403 0.449484337144425 505 2263357 SGTC_2829 7992743 58.44 µM 0.126336068861392 0.424754852867251 no 1404 0.449732953079683 508 16462845 SGTC_22 0964-0034 14.468 µM 0.124823227713037 0.425373101577686 no 1405 0.450331749075798 495 138402 SGTC_583 1488-1091 88.9 µM 0.124370495740529 0.425558154084156 no 1406 0.450510966467478 500 4303273 SGTC_1408 3909-7976 48.8 µM 0.12358542333472 0.425879088355897 no 1407 0.45082176724635 491 24152374 SGTC_2128 5255449 168.493 µM 0.123522729350942 0.425904719510739 no 1408 0.450846588347699 474 736008 SGTC_1432 4049-0298 68.4 µM 0.123401971179645 0.425954089904888 no 1409 0.450894398114819 503 741646 SGTC_3281 9140613 49.47 µM 0.121909189852992 0.426564489587111 no 1410 0.451485468733665 461 16013766 SGTC_552 k242-0005 476 µM 0.120909761977508 0.426973254995677 no 1411 0.451881254981018 498 4088318 SGTC_152 4469-0003 551.229 µM 0.120480679806067 0.427148773439696 no 1412 0.452051191718183 474 697280 SGTC_117 lucigenin 22.078 µM 0.118748541464447 0.427857460525085 no 1413 0.452737289032918 492 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_837 0091-0265 12.5 µM 0.118522839807054 0.427949821293299 no 1414 0.452826699546629 490 759367 SGTC_3123 9126162 49.47 µM 0.116890024098021 0.428618113166674 no 1415 0.45347360178782 501 25239884 SGTC_1194 1488-0194 225 µM 0.116605246941077 0.428734690060007 no 1416 0.453586439817774 478 1391452 SGTC_2520 obtusaquinone 4.71 µM 0.116340684797708 0.428842997270387 no 1417 0.453691271355415 517 5967872 SGTC_1310 1188-0297 994 nM 0.115736682219698 0.429090285649794 no 1418 0.453930616691505 489 1588352 SGTC_2976 9009005 19.48 µM 0.114991140592291 0.429395560766957 no 1419 0.454226072122225 509 2993148 SGTC_536 3852-0578 10.6 µM 0.114180672698871 0.429727468984363 no 1420 0.454547286325939 456 2869208 SGTC_2841 9004761 38.96 µM 0.11190219035869 0.430660833656592 no 1421 0.455450479929347 479 2991039 SGTC_177 1327-0068 8.361 µM 0.110821761401551 0.431103559725676 no 1422 0.45587884427045 487 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.110459643375664 0.431251963792357 no 1423 0.456022426941751 497 2333 A French combination drug. SGTC_518 1021-0119 62.6 µM 0.110318944927956 0.431309627782662 no 1424 0.456078216543267 474 1097762 SGTC_654 1124-0271 80.9 µM 0.109654370562407 0.43158201736431 no 1425 0.456341744563271 499 5403748 SGTC_2723 salbutamol 83.58 µM 0.109395240137403 0.431688236165123 no 1426 0.456444504456061 499 9884233 β2-adrenoceptor agonist SGTC_1216 1165-0504 9.65 µM 0.107002060524802 0.432669444413004 no 1427 0.457393672539762 482 6304004 SGTC_464 bw-b 70c 158 µM 0.106744881096632 0.432774913294885 no 1428 0.457495688012988 500 5353454 SGTC_468 gf-109203x 121 µM 0.106330015021955 0.432945059315463 no 1429 0.457660259015338 509 2396 A protein kinase C inhibitor. SGTC_2641 levomentholum 100 µM 0.106281083093109 0.432965128233516 no 1430 0.45767967003943 513 16666 SGTC_1642 st009582 77.7 µM 0.105030558002075 0.433478076529909 no 1431 0.458175780518049 497 6739311 SGTC_2124 5246320 200 µM 0.104252002665514 0.433797485947832 no 1432 0.458484683302137 492 579342 SGTC_326 k292-0812 17.5 µM 0.103130581271759 0.434257635226365 no 1433 0.458929667038577 507 3579357 SGTC_1256 0570-0116 285 µM 0.102636490572939 0.434460402203641 no 1434 0.459125740236231 481 410638 SGTC_164 4100-3994 89.624 µM 0.10112967443851 0.435078881871189 no 1435 0.459723761000035 522 4615967 SGTC_2585 alliin 100 µM 0.099172744553257 0.435882349747941 no 1436 0.460500557425642 511 87310 A garlic compound which reacts with lipids. SGTC_3138 9097216 49.47 µM 0.0987262526687487 0.43606570567654 no 1437 0.460677812037017 518 25237486 SGTC_788 1182-0090 188 µM 0.0983999548491933 0.436199711518666 no 1438 0.460807355266124 449 5715185 SGTC_3199 9111318 49.47 µM 0.0979556576100224 0.436382189805362 no 1439 0.460983752032794 496 8548020 SGTC_64 000l-0018 272.079 µM 0.097569465251325 0.436540814711503 no 1440 0.461137085992426 506 6811119 SGTC_594 1487-1584 10.8 µM 0.096915292674234 0.436809533262179 no 1441 0.461396832089715 490 5013332 SGTC_488 nitrendipine 139 µM 0.0968539769316304 0.436834721808893 no 1442 0.461421178995594 514 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2923 7992654 58.14 µM 0.0953566000639638 0.437449924439441 no 1443 0.462015793534799 515 2985126 SGTC_1449 4112-4002 201 µM 0.0947909075799561 0.437682380661022 no 1444 0.462240454526027 485 2059539 SGTC_1490 4089-0339 670 nM 0.0927233054081269 0.438532188953809 no 1445 0.463061690866011 500 742542 SGTC_726 3448-4391 34.2 µM 0.0914367812344656 0.439061108521736 no 1446 0.463572768473806 506 1356692 SGTC_1400 3771-8998 51.5 µM 0.0907945821410103 0.439325172064255 no 1447 0.463827907548146 496 670767 SGTC_2797 7859098 81.82 µM 0.0892330127353416 0.439967380614534 no 1448 0.464448364824045 505 972681 SGTC_3181 9108277 49.47 µM 0.087926474625001 0.440504826862841 no 1449 0.464967557191692 513 17097298 SGTC_2129 girgensonine 121.053 µM 0.0878236569527939 0.440547125719258 no 1450 0.465008417441357 517 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1789 tunicamycin 25 nM 0.0865809278784325 0.441058433939419 no 1451 0.465502313155385 510 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2059 5238311 157 µM 0.0854081462520002 0.441541053136634 no 1452 0.465968458528199 497 703021 SGTC_1040 k898-0338 155 µM 0.0848087664073589 0.441787741503887 no 1453 0.466206712033635 506 20969351 SGTC_83 0170-0301 39.027 µM 0.084565557939782 0.441887845909484 no 1454 0.466303390865517 507 3089716 SGTC_1202 1988-0068 29.6 µM 0.0834572615681634 0.442344066685381 no 1455 0.466743979559018 508 2850480 SGTC_1910 st062352 60.4 µM 0.0796570812125532 0.443908955629848 no 1456 0.46825499758126 506 2245730 SGTC_3295 9122362 53.5725 µM 0.0788600180323065 0.444237292759268 no 1457 0.468571982573567 502 4730473 SGTC_3082 9117008 49.47 µM 0.0784638093005019 0.444400518715844 no 1458 0.468729558715906 514 41448529 SGTC_1002 4049-0206 172 µM 0.0779037702671146 0.444631253856467 no 1459 0.46895230014437 511 4662749 SGTC_1527 coumarin 137 µM 0.077460607229005 0.444813849585791 no 1460 0.469128563978764 520 323 A hepatotoxic, DNA x-linker. SGTC_2445 5742597 35.57 µM 0.07710152981224 0.444961808246942 no 1461 0.469271388005542 509 1774255 SGTC_2514 salinomycin 42.74 µM 0.0767914451553842 0.445089585501552 no 1462 0.469394728210177 508 23682228 A polyether potassium ionophore. SGTC_2221 6807166 181.081 µM 0.0757224089007178 0.445530149239577 no 1463 0.469819973725399 502 674925 SGTC_2486 5283202 22.39 µM 0.0751441977800777 0.445768465627071 no 1464 0.470049991232515 500 1377751 SGTC_1646 st011709 75.6 µM 0.0743879277792294 0.44608020060043 no 1465 0.470350857212815 520 5757843 SGTC_1635 st007035 42.4 µM 0.074114161893147 0.446193055299053 no 1466 0.47045977334599 507 3716403 SGTC_1149 3909-7961 23.3 µM 0.0738664909744865 0.44629515660707 no 1467 0.470558309655445 521 735261 SGTC_3335 9143315 29.6265 µM 0.0725414317905678 0.446841467076355 no 1468 0.471085517250023 508 4899691 SGTC_2725 haloperidol 53.21 µM 0.0720618452440811 0.447039221393415 no 1469 0.471276345167252 517 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1249 0481-0015 10.2 µM 0.0717504761774733 0.447167619406823 no 1470 0.471400242731912 519 4227577 SGTC_1240 0356-0016 42.1 µM 0.0716284929348867 0.447217922657821 no 1471 0.471448782113236 519 4305613 SGTC_1163 k060-0048 49.9 µM 0.0715333220330441 0.447257169669095 no 1472 0.471486652664381 516 6809982 SGTC_2456 5770359 74.46 µM 0.0707591233688313 0.447576456407236 no 1473 0.47179473253274 521 3118787 SGTC_548 1436-0017 110 µM 0.0705739918412672 0.447652811414082 no 1474 0.471868405144813 516 9677137 SGTC_1876 myriocin 605 nM 0.0704641143257225 0.447698129834027 no 1475 0.471912131072987 520 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3227 9130768 49.47 µM 0.0698604300897778 0.447947128477507 no 1476 0.472152374179034 521 17720899 SGTC_1450 4112-4260 37.6 µM 0.0694360695893925 0.448122174632122 no 1477 0.472321259405475 523 1633175 SGTC_362 0310-0100 9.03 µM 0.06932712726455 0.44816711431698 no 1478 0.472364616622649 511 790235 SGTC_950 1165-0508 94.1 µM 0.0679256587782449 0.448745291742916 no 1479 0.472922406584515 506 6148369 SGTC_2389 9091542 195.52 µM 0.0670285527878077 0.449115451072671 no 1480 0.473279486235756 517 3626624 YOL127W RPL25 SGTC_1003 4049-0218 100 µM 0.0670192502162599 0.449119289685202 no 1481 0.473283189098509 517 295161 SGTC_341 1486-1430 230 µM 0.0668894886066384 0.449172835003895 no 1482 0.473334840587168 517 2054753 YPL210C SRP72 SGTC_1790 st045711 43.5 µM 0.0663774203457347 0.449384145801884 no 1483 0.473538673251738 511 585119 SGTC_2602 kawain 100 µM 0.0660998147420594 0.449498708919557 no 1484 0.473649179172486 509 5369129 SGTC_2201 6605497 169.863 µM 0.0659745071611986 0.449550422609437 no 1485 0.47369906078133 516 670741 SGTC_1955 wogonin 32.4 µM 0.0658162406876732 0.449615739461833 no 1486 0.473762063036325 517 5281703 A flavanone. SGTC_2971 9092186 9.93 µM 0.0656639098841533 0.449678607942082 no 1487 0.473822703056988 523 25236400 SGTC_3098 9119039 49.47 µM 0.0651763463079682 0.449879838899027 no 1488 0.47401679699433 521 17161528 SGTC_1263 0774-1208 64.8 µM 0.0646260996045999 0.450106956392076 no 1489 0.474235851832067 523 906585 SGTC_261 5-fluorouridine 15.376 µM 0.0636942611021279 0.45049161532826 no 1490 0.474606837223431 518 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1801 st050089 28.441 µM 0.0635958277180571 0.450532250929127 no 1491 0.474646027008822 490 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1062 mesoridazine 14.2 µM 0.0635426797198555 0.45055419188021 no 1492 0.474667187194514 516 4078 A neuroleptic. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.063378092283033 0.450622139045707 no 1493 0.474732715999399 517 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1854 st056233 32.9 µM 0.0604396638283122 0.45183546168855 no 1494 0.475902734607498 515 5393174 SGTC_2072 5231554 129 µM 0.0602351555866733 0.451919923191446 no 1495 0.475984173213813 526 789545 SGTC_2891 9063876 19.48 µM 0.0587578655203394 0.452530105497418 no 1496 0.476572484443998 529 6472478 SGTC_1499 4480-0877 67.3 µM 0.0554678977150145 0.453889399998765 no 1497 0.477882852236917 521 2861909 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0553854453083898 0.453923473327368 no 1498 0.477915695500109 510 4330530 SGTC_2719 novobiocin 32.65 µM 0.053972300924302 0.45450750555022 no 1499 0.47847861636264 511 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2308 7584454 197.62 µM 0.053418670986782 0.454736339717095 no 1500 0.478699164577435 516 893577 SGTC_2887 9044784 58.44 µM 0.053131090310759 0.454855212568294 no 1501 0.478813729971828 531 6465546 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0531009705490721 0.454867662950264 no 1502 0.478825729079678 523 804 An inhibitor of viral and cellular DNA polymerases. SGTC_778 3456-2434 196 µM 0.0527195951181638 0.45502531310758 no 1503 0.478977663044525 524 5539063 SGTC_3306 9127676 59.7925 µM 0.0519205310206178 0.45535564725904 no 1504 0.479296007474741 521 41905287 SGTC_3037 9091026 49.47 µM 0.0509139323314102 0.455771820393772 no 1505 0.479697051757078 524 25236398 YIL048W NEO1 SGTC_2113 5491891 107.031 µM 0.050487941677258 0.455947958716497 no 1506 0.479866779149195 518 789979 SGTC_1812 st052057 4.327 µM 0.0502492394528654 0.456046660935287 no 1507 0.479961886838293 511 3645418 SGTC_1267 0828-0272 9.49 µM 0.0494308020561037 0.45638510140928 no 1508 0.480287990833332 514 745334 SGTC_1375 2910-0797 186 µM 0.0489381129636156 0.456588853622325 no 1509 0.480484307741586 535 742508 SGTC_2024 5144227 134 µM 0.048756823924622 0.456663828815004 no 1510 0.480556545370479 513 3475211 SGTC_256 clotrimazole 625 nM 0.0485680853915547 0.456741886512915 no 1511 0.480631752052403 519 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2482 5981709 142.65 µM 0.0483758499162163 0.456821392177518 no 1512 0.48070835287029 514 877755 SGTC_2908 7930301 100 µM 0.0478640099013112 0.457033089830969 no 1513 0.480912311218468 507 2223178 SGTC_2464 5717415 7.67 µM 0.0478057115658542 0.457057202868158 no 1514 0.480935542295774 526 5285744 SGTC_381 3461-2219 42.7 µM 0.0477434117575013 0.457082971147332 no 1515 0.480960367976036 521 2883159 SGTC_1974 st069448 26.9 µM 0.0473702432957193 0.457237323856607 no 1516 0.48110907239836 521 6323587 YNR016C ACC1 SGTC_2323 6148992 148.28 µM 0.0472426367141486 0.457290106919443 no 1517 0.481159923127721 513 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2322 7413319 38.22 µM 0.0468187029860083 0.457465467860311 no 1518 0.481328861275563 519 1840400 SGTC_1625 st003711 30.1 µM 0.0461031611260912 0.457761471791665 no 1519 0.481614013237548 519 24207034 YER133W GLC7 SGTC_1251 0490-5699 265 µM 0.0458877701610088 0.457850578892481 no 1520 0.48169985095373 522 3883818 SGTC_2184 6075246 200 µM 0.0452730278793535 0.458104909007755 no 1521 0.481944843010936 534 2267320 SGTC_269 exalamide 29 µM 0.0433429488444485 0.458903528971958 no 1522 0.482714077572669 530 3316 A derivative of salicylamide. SGTC_775 4577-0580 57.3 µM 0.0410991759207553 0.45983215618507 no 1523 0.483608415785014 524 2006902 SGTC_2180 6301957 200 µM 0.0405367668874829 0.460064954188337 no 1524 0.483832597691006 521 845462 SGTC_3354 9151612 71.43 µM 0.0393951956229881 0.460537526861387 no 1525 0.484287655137651 528 27261949 SGTC_2676 harmalol 100 µM 0.0382842753802649 0.460997464551425 no 1526 0.484730514012012 524 5459187 A monoamine oxidase inhibitor SGTC_26 0302-0163 425.158 µM 0.0379256061136087 0.461145970194794 no 1527 0.48487349850293 532 3100915 SGTC_1157 4092-0394 27.6 µM 0.0379078514106433 0.461153321602832 no 1528 0.484880576514837 530 3659885 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.037383157599363 0.461370579223006 no 1529 0.485089750786282 532 688664 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0353002132456117 0.462233167778479 no 1530 0.485920176646359 533 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2617 dihydrotanshinone i 20.83 µM 0.0352868461442064 0.462238703938231 no 1531 0.485925506028014 534 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_233 rapamycin 362 pM 0.0343642138739974 0.462620841771648 no 1532 0.486293359899361 531 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1867 st057372 64 µM 0.0338992683084241 0.462813427029746 no 1533 0.486478738329742 516 688837 SGTC_921 1561-0023 372 µM 0.033496639083024 0.462980207259963 no 1534 0.486639272976388 532 24050882 SGTC_3194 9111903 49.47 µM 0.0326974601106841 0.463311268680725 no 1535 0.486957924673908 534 17087251 SGTC_1126 isoteolin 1.0172 µM 0.0326096929851283 0.463347627933362 no 1536 0.486992920029131 531 133323 SGTC_1330 1469-0054 61.8 µM 0.0314527081697833 0.463826960084673 no 1537 0.487454253439788 543 7102664 SGTC_3165 9101544 49.47 µM 0.0310031884083502 0.464013207738229 no 1538 0.487633498457176 529 5002184 SGTC_1641 st009299 47.1 µM 0.030780321350845 0.464105550246271 no 1539 0.487722367135309 533 4046054 SGTC_2802 7925815 54.55 µM 0.0293868355234856 0.464682969380049 no 1540 0.488278036000956 529 1262923 SGTC_143 4032-1194 15.74 µM 0.0290839917572334 0.464808468722104 no 1541 0.488398801562449 536 1806963 SGTC_3322 9139058 2.11 µM 0.028891901049153 0.464888073488372 no 1542 0.488475402476781 513 4908926 YPR165W RHO1 SGTC_2703 st077852 53.4 µM 0.0272840762667188 0.465554430775562 no 1543 0.48911657871982 524 6281836 SGTC_2974 9094440 9.66 µM 0.0269219161047117 0.465704540167822 no 1544 0.489261006663799 538 25236134 SGTC_812 4251-0442 148 µM 0.0268035143465924 0.465753616796117 no 1545 0.489308225091548 540 5723007 SGTC_1359 1582-0056 520 nM 0.0267414634956821 0.465779336609964 no 1546 0.489332970929428 524 3661189 SGTC_2920 7982904 15.77 µM 0.0262287850691894 0.465991845097019 no 1547 0.48953742830567 533 6456808 SGTC_872 0588-0139 234 µM 0.0261673483460947 0.466017311663556 no 1548 0.489561929602541 540 2047100 SGTC_1287 0971-0001 34.6 µM 0.025972942091713 0.466097897278463 no 1549 0.489639460125483 532 4665869 SGTC_2041 5107442 45.335 µM 0.0259660199289886 0.466100766690908 no 1550 0.489642220737811 529 793005 SGTC_2173 5763948 167 µM 0.0252459507348103 0.466399263277691 no 1551 0.489929392618059 542 2867177 SGTC_701 4424-0219 185 µM 0.0251263786306587 0.466448832383244 no 1552 0.489977079858503 527 2911779 SGTC_1899 st063254 59.6 µM 0.0245741462224241 0.466677769330232 no 1553 0.490197320698185 530 3093813 SGTC_1094 duloxetine 25.4 µM 0.0241917315437567 0.466836312034688 no 1554 0.490349836736978 534 60834 A selective serotonin reuptake inhibitor. SGTC_2146 5545642 200 µM 0.0241632871711096 0.466848104804527 no 1555 0.490361181083701 540 825326 SGTC_946 3434-1334 87.4 µM 0.023859910736676 0.466973883634265 no 1556 0.49048217588459 532 4047976 SGTC_2951 9072950 58.06 µM 0.022402786888761 0.467578047926867 no 1557 0.491063328647511 538 16488155 SGTC_1652 st011932 78 µM 0.0220688767305378 0.467716506985533 no 1558 0.491196506599059 537 1551076 SGTC_1833 st055984 71 µM 0.0197703519910458 0.468669717470552 no 1559 0.4921132844716 540 676288 SGTC_3088 9117578 49.47 µM 0.0173940274540177 0.469655380741675 no 1560 0.493061136918598 534 678341 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0167718756608477 0.469913470807349 no 1561 0.493309303356215 538 107982 A Capsaicinoid. SGTC_2582 agaric acid 100 µM 0.0162502778311303 0.470129857359408 no 1562 0.493517362419485 534 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1895 st058434 18.3 µM 0.0160593766612806 0.470209055537511 no 1563 0.493593511030179 539 5393175 SGTC_3280 9140961 49.47 µM 0.0159194864071363 0.470267091829985 no 1564 0.493649312033576 540 4901226 SGTC_142 0335-0849 62.6745 µM 0.0158279032403568 0.470305087295442 no 1565 0.49368584382814 541 3889043 YPR107C YTH1 SGTC_429 1112-0049 25.5 µM 0.0157320718408135 0.47034484553124 no 1566 0.493724070265552 540 2836170 SGTC_708 3448-5400 146 µM 0.0147396523205742 0.470756594794628 no 1567 0.494119942405966 544 3462195 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0147005386536152 0.470772823477798 no 1568 0.494135544810991 541 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1653 st012112 65 µM 0.014341815999259 0.470921663644786 no 1569 0.494278639356402 542 720429 SGTC_2952 9073731 13.78 µM 0.0141645697299632 0.470995207655245 no 1570 0.494349343204943 535 16457353 SGTC_2026 5148700 152 µM 0.0136248467274285 0.471219158614842 no 1571 0.494564640743758 542 79838 SGTC_1418 3966-3099 2.4 µM 0.0134298003473892 0.471300092786904 no 1572 0.494642445872225 543 740335 SGTC_2347 9049783 174.81 µM 0.0128834417256986 0.471526809691036 no 1573 0.494860392560228 544 6467988 YPL169C MEX67 SGTC_1491 4138-0063 26.5 µM 0.0128257140271574 0.471550764909737 no 1574 0.49488342067726 542 23883227 SGTC_1269 0831-0796 3.05 µM 0.0123123266515837 0.471763809392357 no 1575 0.495088216427868 544 927758 SGTC_1187 1391-0724 117 µM 0.0122006698077916 0.471810145601442 no 1576 0.495132757718069 535 6997986 SGTC_1057 3448-5381 134 µM 0.0121494222093537 0.471831412848701 no 1577 0.495153201036622 540 5497911 SGTC_1394 3474-0001 65.7 µM 0.0116462861513606 0.472040213599783 no 1578 0.495353909074323 535 5017666 YIL048W NEO1 SGTC_1764 st044502 93.5 µM 0.0108890304778986 0.472354488099586 no 1579 0.495655991195523 537 8407 SGTC_1809 st050081 57.6 µM 0.00948547849260799 0.472937032371048 no 1580 0.496215898324863 544 5036894 SGTC_3164 9100705 49.47 µM 0.00935377447274784 0.472991699116492 no 1581 0.496268438295876 542 17174235 SGTC_2766 oltipraz 83.91 µM 0.00923907376832779 0.473039308664046 no 1582 0.496314195279153 541 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_560 2332-1943 155 µM 0.00711163349816769 0.473922427867556 no 1583 0.497162892629489 547 21177716 SGTC_803 4488-1585 147 µM 0.00707388177098206 0.473938100112363 no 1584 0.497177953010793 543 747204 SGTC_151 3013-0144 2.285 µM 0.00675514945381196 0.474070420191057 no 1585 0.497305105768048 547 906558 YHR107C CDC12 SGTC_2910 7948405 25.97 µM 0.00636555341355272 0.474232162863018 no 1586 0.497460528755202 545 2971328 SGTC_408 cantharidin 100 µM 0.00410657762441012 0.475170070413192 no 1587 0.498361717162535 545 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2732 terfenadine 20 µM 0.00403006994462592 0.475201838190188 no 1588 0.49839223905818 545 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3017 9080681 49.47 µM 0.00165136290554775 0.476189610594072 no 1589 0.499341201816114 547 16451914 SGTC_2681 menadione 3.18 µM 0.00141612360092937 0.476287303180487 no 1590 0.499435048610141 548 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2402 5553605 200 µM 0.000772636408937305 0.476554544393351 no 1591 0.499691762699765 547 6758546 SGTC_2947 9072639 7.68 µM 0.000661662881293449 0.476600632938213 no 1592 0.49973603472054 547 16488146 SGTC_765 1319-0117 244 µM 9.90761958845904e-05 0.476834286271937 no 1593 0.499960474316545 548 3487746 YGL099W LSG1 SGTC_1380 2291-0730 164 µM -0.000236228485786394 0.476973548705113 no 1594 0.499905758470061 549 2999191 SGTC_1971 st069429 63.5 µM -0.000752671971543779 0.477188049196756 no 1595 0.49969972735563 549 1246522 YGL099W LSG1 SGTC_3019 9081971 49.47 µM -0.00108861827704821 0.477327585242935 no 1596 0.499565704227848 546 16451803 SGTC_2492 derrusnin 100 µM -0.00196542784734346 0.477691783102506 no 1597 0.499215908237429 547 1715307 Part of coumarin class of compounds. SGTC_3229 9132204 49.47 µM -0.00501233627713429 0.478957511577541 no 1598 0.498000375508397 550 17682924 SGTC_2320 7373003 200 µM -0.0058241992291502 0.479294807166087 no 1599 0.497676493814075 553 5415828 SGTC_410 α-linolenic acid 100 µM -0.00600001772914766 0.479367854466525 no 1600 0.497606353606657 551 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_692 k241-0027 77.8 µM -0.00606265404405861 0.479393878139631 no 1601 0.497581365786849 552 3600480 SGTC_996 3970-0799 1.8 µM -0.00643569932137773 0.479548870049513 no 1602 0.497432545160001 542 6615648 YGL040C HEM2 SGTC_1100 amiodarone 5.07 µM -0.00702342814080097 0.479793064400086 no 1603 0.497198080597059 552 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1911 st060208 74.3 µM -0.00898142639125551 0.480606643647091 no 1604 0.496416977445641 555 688783 SGTC_1261 0712-0010 12.7 µM -0.00916014233945888 0.480680907025371 no 1605 0.496345683030897 557 2840123 SGTC_696 1560-0013 611 µM -0.0094129449531674 0.48078595741875 no 1606 0.496244833728672 553 1650269 SGTC_3238 9133470 49.47 µM -0.00950774059968428 0.480825349444297 no 1607 0.496207017429573 564 3534688 SGTC_1991 st073000 8.92 µM -0.0095131543277353 0.480827599107205 no 1608 0.496204857762231 553 4301969 YIL048W NEO1 SGTC_1505 k297-0037 20.6 µM -0.00988363212326838 0.480981551795579 no 1609 0.496057065457237 552 4089396 SGTC_1847 st056231 15 µM -0.0113339770830698 0.481584272225063 no 1610 0.495478494141384 553 5393180 SGTC_1455 4262-0120 131 µM -0.0138868117204145 0.482645256139112 no 1611 0.494460141719638 561 1529587 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0140263251747917 0.482703242953319 no 1612 0.49440448932446 555 16623 A steroid. SGTC_2281 7943571 200 µM -0.0167695620106713 0.483843503721139 no 1613 0.493310226239299 556 1244024 SGTC_777 1315-0167 517 µM -0.0174183906121389 0.484113217130969 no 1614 0.493051418897015 554 4221767 SGTC_2928 9011484 9.79 µM -0.0188778425576668 0.484719927246122 no 1615 0.49246927773458 562 2994751 SGTC_1872 amphotericin b 148 nM -0.0205368162303254 0.485409623606819 no 1616 0.491807571579159 553 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2043 5101342 149 µM -0.0209078913592056 0.485563899229952 no 1617 0.491659565803324 556 678451 SGTC_245 methotrexate 289.6 µM -0.0217165171662164 0.485900095343045 no 1618 0.491337044043299 561 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_122 0236-0016 402.397 µM -0.021946370322678 0.485995661456224 no 1619 0.491245367750716 558 6808838 SGTC_798 1287-0182 476 µM -0.0220455093751502 0.486036880777257 no 1620 0.491205826557656 577 1649755 SGTC_2034 5197015 53.07 µM -0.0221961019685387 0.486099493366127 no 1621 0.491145763502221 565 780676 SGTC_1792 st045773 43.6 µM -0.0225156423695725 0.486232351310483 no 1622 0.491018317178356 560 2919270 SGTC_2313 7726885 200 µM -0.0234414829292685 0.486617304241058 no 1623 0.490649057747375 558 726423 SGTC_1494 4358-1428 177 µM -0.0245029198463093 0.487058651764027 no 1624 0.490225727357416 560 1564571 SGTC_3114 9122766 49.47 µM -0.0248009295733419 0.487182567657982 no 1625 0.490106874797643 562 17176985 SGTC_2900 5328528 85.29 µM -0.0248105240020392 0.487186557153116 no 1626 0.490103048351813 559 795359 SGTC_1104 tacrolimus 29.8 µM -0.0268133059631249 0.488019368846184 no 1627 0.489304320205175 559 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1257 0669-0121 16 µM -0.0273743891949794 0.488252692173967 no 1628 0.489080562526807 561 4307855 SGTC_1334 1486-0610 236 µM -0.0279157656596842 0.488477824364877 no 1629 0.488864667082901 559 3742339 SGTC_105 0111-0055 734.78 µM -0.0283513651308561 0.488658971707952 no 1630 0.488690956797136 581 5179370 SGTC_2409 alverine citrate 63.97 µM -0.0284001678086677 0.488679266818002 no 1631 0.488671495182231 569 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0297427234468107 0.489237594101888 no 1632 0.488136119298567 567 1377 SGTC_1205 4161-2785 76 µM -0.0304753646655648 0.489542285845032 no 1633 0.487843970201133 595 3498106 SGTC_1930 st074634 34.3 µM -0.0307258349424715 0.48964645314478 no 1634 0.487744093790872 573 684253 YOR116C RPO31 SGTC_81 0411-0046 9.971 µM -0.0307283572782684 0.489647502154726 no 1635 0.4877430879994 559 12925265 SGTC_3126 9127922 49.47 µM -0.0317687657466093 0.490080201885433 no 1636 0.487328227690509 558 45595682 SGTC_1969 st069479 40.1 µM -0.0333427518288679 0.490734835416859 no 1637 0.486700630834296 565 3895485 SGTC_1565 sinapyl alcohol 95.1 µM -0.0341058536018881 0.491052224703192 no 1638 0.486396370351445 562 5280507 A phenol propionate derived from cinnamic acid. SGTC_2729 fluphenazine 10.66 µM -0.0350454195957465 0.491443016748338 no 1639 0.486021761749517 567 3372 An atypical antipsychotic. SGTC_645 0845-0943 5.41 µM -0.0355040779081832 0.491633788706963 no 1640 0.485838897363229 563 1885106 SGTC_1129 3453-1384 223 µM -0.0361011247256527 0.491882124122634 no 1641 0.485600862756299 593 1084452 SGTC_1017 4239-0030 168 µM -0.0361782272537356 0.491914194348925 no 1642 0.485570123378469 562 1149593 SGTC_58 0957-0393 9 µM -0.0362108535947031 0.491927765049889 no 1643 0.4855571158746 559 6997992 SGTC_1232 0279-0259 161 µM -0.0367697868365626 0.492160250905636 no 1644 0.48533428218117 569 1560000 SGTC_2849 9019321 12.99 µM -0.0372124768245495 0.492344387778337 no 1645 0.485157795218031 562 16489627 SGTC_2460 5552655 174.22 µM -0.0376634859847008 0.492531986687565 no 1646 0.484977994645346 574 5401989 SGTC_3170 9103054 49.47 µM -0.0384041572431868 0.492840075170175 no 1647 0.484682723214086 586 16432970 SGTC_1015 4130-4525 82 µM -0.039375438925905 0.493244094455688 no 1648 0.484295530808686 574 1363237 SGTC_2145 5634607 200 µM -0.0396889783997916 0.493374517435009 no 1649 0.484170544358788 573 308662 SGTC_3310 9130229 44.1445 µM -0.0397493556291226 0.493399632625987 no 1650 0.484146476321743 594 7761258 SGTC_262 fenpropimorph 62.5 µM -0.0398694437208717 0.493449585896147 no 1651 0.484098606051755 569 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_718 1130-0073 349 µM -0.0407403833292458 0.493811875313829 no 1652 0.483751433532273 576 6740020 SGTC_994 3910-0338 138 µM -0.0413912337041225 0.494082616382057 no 1653 0.483492000650235 561 3479481 SGTC_3347 9188721 44.724 µM -0.0423282953133075 0.494472420499508 no 1654 0.483118494548179 572 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_704 1310-0270 142 µM -0.0425645067454056 0.494570681896769 no 1655 0.483024344674004 575 5718033 SGTC_2531 methyl deoxycholate 70.07 µM -0.0428802058909269 0.494702009835156 no 1656 0.482898513823123 572 16667744 Haematoxylin. SGTC_715 0868-0130 184 µM -0.0461193301780237 0.496049486351958 no 1657 0.481607569573152 576 2876258 SGTC_903 1134-0042 114 µM -0.0463163310376618 0.496131440368314 no 1658 0.481529061495963 568 701009 SGTC_1519 esterone 74 µM -0.047422462062632 0.4965916031215 no 1659 0.481088263510233 578 698 A steroid. SGTC_18 0111-0177 500 nM -0.0480186487530139 0.496839625305412 no 1660 0.480850690097198 568 721752 SGTC_2878 9043973 25.97 µM -0.0489447846327248 0.497224913455393 no 1661 0.480481649316422 574 6465167 SGTC_2696 st077691 74.316 µM -0.0491512606233109 0.497310811316311 no 1662 0.480399376335983 573 757133 SGTC_165 k038-0023 64.381 µM -0.0498811677464676 0.497614467257853 no 1663 0.480108542290396 569 46368543 SGTC_174 3553-0389 74.3 µM -0.0506455430226677 0.497932464118065 no 1664 0.479803985641825 568 738071 SGTC_61 0978-8327 98.565 µM -0.0510538033601386 0.498102309913345 no 1665 0.479641323765458 597 6150059 YHR072W ERG7 SGTC_633 0437-0093 97.7 µM -0.0510729774250678 0.498110286778983 no 1666 0.479633684386491 569 2831118 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0511246922837323 0.498131801390133 no 1667 0.479613080060299 590 65057 A dermal irritant. YDR527W RBA50 SGTC_2674 ligustilide 100 µM -0.0511508245532114 0.498142673037816 no 1668 0.479602668415616 570 5319022 A signalling regulator. SGTC_1888 azatryptophan 97.5 µM -0.0514271581937273 0.498257634509098 no 1669 0.479492572145997 580 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2649 anisomycin 9.56 µM -0.0514791167367745 0.498279250534887 no 1670 0.479471871106722 589 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_227 fluconazole 33.516 µM -0.0517965273487125 0.498411301226626 no 1671 0.479345411306638 577 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1222 0366-0074 1.18 µM -0.0518516137411331 0.498434218551082 no 1672 0.479323464507062 584 286520 SGTC_3029 9088683 49.47 µM -0.0519365255184179 0.498469543995729 no 1673 0.479289635190771 572 25236615 SGTC_3067 9117431 49.47 µM -0.0538107966949656 0.499249290718973 no 1674 0.478542953732767 577 17150885 SGTC_955 1216-0110 33 µM -0.0540822965188903 0.499362242184262 no 1675 0.478434798467114 569 3619719 SGTC_2850 9015429 58.44 µM -0.0545399290189649 0.499552630122065 no 1676 0.478252498578616 572 6457570 SGTC_632 0781-2353 4.65 µM -0.0545457145380693 0.499555037060802 no 1677 0.478250193921068 591 6811515 YHR007C ERG11 SGTC_517 1365-0151 113 µM -0.0554156010543266 0.499916934462574 no 1678 0.477903683545863 598 768657 SGTC_315 k915-0449 187 µM -0.0558149273431634 0.499916934462574 no 1679 0.477744621590837 586 20970215 YNL149C PGA2 SGTC_1018 4259-0013 28.1 µM -0.0563557520593923 0.499691936052529 no 1680 0.477529202821349 590 6801262 SGTC_1661 st013063 9.66 µM -0.0598460121512368 0.498239894418945 no 1681 0.476139139413862 588 721395 SGTC_1647 st011722 22.4 µM -0.0601759380830642 0.498102637304973 no 1682 0.476007754802802 584 2854783 SGTC_2699 st077704 54.6 µM -0.0605095589561721 0.497963843235105 no 1683 0.475874901427823 582 645852 SGTC_1524 corynanthine 62.1 µM -0.0615048560767429 0.497549777933251 no 1684 0.475478573570119 616 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1318 1280-3875 124 µM -0.062472849436064 0.497147074119383 no 1685 0.475093141353172 582 373245 SGTC_680 0417-1641 114 µM -0.0629833527968778 0.496934696069215 no 1686 0.47488988027144 572 2835990 SGTC_1493 4348-0038 111 µM -0.0644822194011175 0.496311147403093 no 1687 0.474293132253455 574 800424 SGTC_24 0417-1663 219 µM -0.0660805335529691 0.495646237185724 no 1688 0.473656854473197 592 4329390 SGTC_2903 5923464 63.88 µM -0.0667942247475232 0.495349340296283 no 1689 0.473372760563585 595 2876576 SGTC_51 1013-0126 23.419 µM -0.0671611408516974 0.495196703493837 no 1690 0.473226710176505 575 1627850 SGTC_1794 st048918 76.9 µM -0.06758076739861 0.49502214005316 no 1691 0.473059682892145 577 672303 SGTC_1771 st048882 4.1505 µM -0.0682622884069022 0.494738631313215 no 1692 0.472788421783441 577 4580403 SGTC_1503 4585-0012 61.3 µM -0.0687769981928731 0.494524516816437 no 1693 0.472583563753062 599 2922052 SGTC_705 1124-0212 310 µM -0.0706988292934722 0.493725067341754 no 1694 0.471818726298071 572 9554485 SGTC_723 4182-0001 115 µM -0.0712670810819153 0.493488688820557 no 1695 0.471592597040157 585 744821 YLR208W SEC13 SGTC_1466 k213-0079 57.5 µM -0.0717848875826317 0.493273296265205 no 1696 0.471386549876125 580 3657981 SGTC_2953 9074162 66.49 µM -0.071810246520061 0.493262747729205 no 1697 0.471376459165599 572 16451992 SGTC_922 1866-0035 480 µM -0.0725633753462163 0.492949471540861 no 1698 0.471076786048034 614 3156169 SGTC_2047 4141938 200 µM -0.0730670580082197 0.492739958957591 no 1699 0.470876377733252 579 3807862 SGTC_3011 9081274 71.4286 µM -0.0745995190258406 0.492102526769916 no 1700 0.470266678410209 578 6625322 SGTC_364 0083-0097 67.7 µM -0.0752141436604608 0.491846877211656 no 1701 0.470022165608638 595 5207356 SGTC_906 1165-0455 526 µM -0.0752322039110146 0.491839365205138 no 1702 0.47001498096712 612 3252859 SGTC_1167 k781-0610 148 µM -0.0764975464189063 0.491313064185136 no 1703 0.469511632965723 595 4525169 SGTC_912 3474-0017 2.18 µM -0.0767213327575773 0.491219985023389 no 1704 0.469422616735689 581 3360550 SGTC_2293 7624732 200 µM -0.0767716275409217 0.49119906604497 no 1705 0.469402611024015 572 894453 SGTC_2366 9070441 60.58 µM -0.076961282794375 0.491120183446914 no 1706 0.469327172716149 590 6837235 SGTC_1289 0976-0073 69.1 µM -0.077118382542006 0.491054841801108 no 1707 0.469264684697503 600 3391136 SGTC_2126 5251174 33.877 µM -0.0772712940477706 0.490991242378537 no 1708 0.469203863321593 580 790722 SGTC_1355 1499-0035 1.68 µM -0.0780357433231177 0.490673293757708 no 1709 0.46889981030552 592 1548538 SGTC_1105 epirubicin 18.1 µM -0.0785265317071061 0.490469168884204 no 1710 0.468704613065697 598 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3344 9148862 3.898 µM -0.0786626150151145 0.490412570616748 no 1711 0.468650491097516 603 4905352 SGTC_813 k007-0158 173 µM -0.0792541824652895 0.490166534670613 no 1712 0.468415224354458 574 6523916 SGTC_747 3448-8087 38.7 µM -0.0798821103648015 0.489905380322213 no 1713 0.468165509107709 601 5168703 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0804642540138958 0.489663271443815 no 1714 0.467934012592523 587 2374 Ca(2+)-ATPase inhibitor. SGTC_1985 st071382 65.5 µM -0.0804792291570953 0.489657043451633 no 1715 0.467928057687088 619 6123237 SGTC_2564 betulinic acid 100 µM -0.0805896369469816 0.4896111261822 no 1716 0.467884153958034 627 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_413 propylparaben 100 µM -0.0806804778966555 0.489573346629057 no 1717 0.467848031288552 579 7175 A pharmaceutical preservative. SGTC_1877 wortmannin 25 µM -0.0809658256661617 0.489454674864328 no 1718 0.467734565206836 599 312145 A covalent inhibitor of PI 3-kinase. SGTC_2393 9031399 185.94 µM -0.0820644719030157 0.488997773539581 no 1719 0.467297722555708 605 1526623 YDL150W RPC53 SGTC_1184 1269-1718 139 µM -0.0821765864634819 0.488951148512702 no 1720 0.467253145878689 577 5403821 SGTC_589 1227-0070 34.1 µM -0.0827649968788221 0.488706449054467 no 1721 0.467019201023401 585 2841384 SGTC_911 3456-4043 236 µM -0.0828815231620169 0.488657990321226 no 1722 0.466972872933317 578 914281 SGTC_374 0880-0231 82.3 µM -0.083275115829038 0.488494311734753 no 1723 0.466816393123443 592 6833587 SGTC_1554 st069299 38.7 µM -0.0834004260671373 0.488442200898324 no 1724 0.466766574870523 581 24207999 SGTC_745 0469-0705 296 µM -0.0837906432557801 0.488279928561148 no 1725 0.466611443729261 603 3486736 SGTC_1780 st038448 24.544 µM -0.0841577267152877 0.488127278186599 no 1726 0.466465514049289 631 728868 YDL195W SEC31 SGTC_492 tmb-8 126 µM -0.0842842716893732 0.488074655303115 no 1727 0.466415208638125 605 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2639 lactacystin 53 µM -0.0843110357267106 0.488063525683258 no 1728 0.466404569201694 591 3870 A proteasome inhibitor. SGTC_2819 7996655 46.38 µM -0.0845322729649492 0.487971526229695 no 1729 0.466316622272179 589 6456960 SGTC_2159 5658611 73.75 µM -0.0850391127428174 0.487760764029714 no 1730 0.466115147921177 612 793844 SGTC_3278 9139605 49.47 µM -0.0852432740998148 0.48767586736052 no 1731 0.466033994001004 620 7958859 SGTC_682 0kpi-0099 17 µM -0.0853523019581715 0.487630530400048 no 1732 0.465990656122675 598 1714895 YML126C ERG13 SGTC_2144 5628481 200 µM -0.0855423381992788 0.487551508175995 no 1733 0.465915118893249 578 2818399 SGTC_3224 9130643 49.47 µM -0.0923358432796162 0.484726929091554 no 1734 0.463215605590301 596 17644395 SGTC_1820 st053765 18.6 µM -0.0925564284440214 0.484635227063478 no 1735 0.463127980079546 597 3690829 SGTC_2495 cafestol 54.53 µM -0.092977141731616 0.484460329699236 no 1736 0.462960860400648 632 16667697 An anti-infammatory. SGTC_1548 st061468 90.8 µM -0.0933100755978445 0.484321925787199 no 1737 0.462828613918993 587 390799 SGTC_3144 9087057 49.47 µM -0.0935194091065889 0.484234904736454 no 1738 0.462745465513956 617 17249618 SGTC_3129 9127257 49.47 µM -0.0947220060717788 0.483734993469284 no 1739 0.462267819124205 645 837894 SGTC_2513 baicalein 25.65 µM -0.0953437952385353 0.483476529976963 no 1740 0.462020878751901 613 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3188 9110789 49.47 µM -0.0957811589066767 0.483294732086719 no 1741 0.461847190783041 612 849217 SGTC_2283 7944793 200 µM -0.0964257510317651 0.483026802390838 no 1742 0.461591220523214 580 2970533 SGTC_3048 9093155 49.47 µM -0.0975403362938051 0.482563534571532 no 1743 0.461148651599314 575 25236002 SGTC_2594 a-mangostin 100 µM -0.0977148901784836 0.482490984860366 no 1744 0.461079345745116 597 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_19 0279-0214 38.434 µM -0.098025647934099 0.482361826264341 no 1745 0.460955963668359 578 3566274 YBR002C RER2 SGTC_3097 9117246 49.47 µM -0.0984770307549542 0.482174223719933 no 1746 0.460776755048418 584 16423892 SGTC_2229 7354935 190 µM -0.0995694791945801 0.481720199581682 no 1747 0.460343062726919 587 318112 SGTC_3163 9099914 49.47 µM -0.100344058215658 0.481398297050204 no 1748 0.460035590289937 588 16268368 SGTC_554 4483-2211 187 µM -0.101132282676179 0.481070736146261 no 1749 0.459722725771199 599 747107 SGTC_1951 sophoraflavanone G 9.2 µM -0.101775014484895 0.480803646789527 no 1750 0.459467629101078 607 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1224 0823-0416 294 µM -0.102379772633728 0.480552345380851 no 1751 0.45922761919959 611 3598164 SGTC_673 1082-0474 110 µM -0.102439006140675 0.480527731883012 no 1752 0.459204112040835 592 3098046 SGTC_3052 9092717 49.47 µM -0.102582146415611 0.480468252631056 no 1753 0.459147306586402 609 25237534 SGTC_1666 st014829 29 µM -0.103677920247264 0.480012938905955 no 1754 0.458712474649866 602 3858230 SGTC_785 1270-0111 65.3 µM -0.104708884324909 0.479584578596866 no 1755 0.458303406023901 592 6741994 SGTC_482 fipronil 114 µM -0.107621797444902 0.478374407111977 no 1756 0.457147852778034 579 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2992 9074591 71.4286 µM -0.107810291619621 0.478296103843051 no 1757 0.45707308947262 584 17741321 SGTC_2675 theaflavin digallate 100 µM -0.107936630883108 0.478243621112586 no 1758 0.457022979803787 598 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1994 st072947 40.9 µM -0.108244559824924 0.478115705599103 no 1759 0.456900849477544 627 5286565 YDL195W SEC31 SGTC_2256 7954252 200 µM -0.10875774316407 0.477902531204137 no 1760 0.45669732050345 621 2972920 SGTC_1558 st069300 45.6 µM -0.109029901838066 0.477789480094245 no 1761 0.456589386734565 597 24208000 SGTC_431 k089-0097 107 µM -0.109579892369969 0.477561026773611 no 1762 0.456371279086924 625 5499420 SGTC_40 0327-0103 19.753 µM -0.110436241601991 0.477205333855149 no 1763 0.456031706128519 611 409036 SGTC_2964 9083345 53.42 µM -0.110489686214009 0.477183135718813 no 1764 0.456010514499169 594 17741579 SGTC_1908 st060353 56.5 µM -0.110579782807473 0.477145714399396 no 1765 0.455974790065964 631 4227716 SGTC_1208 2323-2347 50.3 µM -0.111486388467719 0.476769170036243 no 1766 0.455615329369884 608 5412760 SGTC_920 mycophenolic acid 780.421 nM -0.111876111555671 0.476607311052703 no 1767 0.455460818945503 594 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_27 0485-0001 32.618 µM -0.112468083471026 0.476361461898377 no 1768 0.455226137426633 598 2054479 SGTC_2845 9003024 42.97 µM -0.112675575698624 0.476275291373223 no 1769 0.455143882841184 595 2990173 SGTC_2428 5615643 7.78 µM -0.113594796591393 0.475893556753413 no 1770 0.454779506184974 597 2253075 SGTC_1209 2323-2347 50.3 µM -0.116578024784063 0.474654834123099 no 1771 0.45359722632368 591 5412760 SGTC_666 0272-0154 136 µM -0.116761772106309 0.474578544807088 no 1772 0.453524418960113 597 6870312 SGTC_1173 0443-0020 122 µM -0.116800124312601 0.4745626216254 no 1773 0.453509222619825 607 5331295 SGTC_1237 0330-0133 46.1 µM -0.117341753971859 0.474337750583047 no 1774 0.453294619335445 612 X1237 YHR072W ERG7 SGTC_580 1123-0028 41 µM -0.118137023254581 0.474007589569371 no 1775 0.45297954426267 601 1677248 YPR107C YTH1 SGTC_278 4092-0821 23.9 µM -0.118833961927021 0.473718265792978 no 1776 0.452703450794863 622 877900 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.120442339282219 0.47305062489842 no 1777 0.45206637679838 596 115019 SGTC_116 0155-0182 31.788 µM -0.12110149139301 0.472777031203888 no 1778 0.451805323955577 607 771486 SGTC_186 3455-3465 67.277 µM -0.121115636905214 0.472771159978716 no 1779 0.451799721946821 594 755278 SGTC_2626 ethyl orsellinate 100 µM -0.122253314974746 0.472298975695116 no 1780 0.451349201915348 604 75653 A natural product. SGTC_496 calpeptin 138 µM -0.122557515893852 0.472172726078552 no 1781 0.451228749073625 601 73364 A calpain inhibitor. SGTC_1656 st012921 11 µM -0.12411731359176 0.471525422257608 no 1782 0.450611194947051 594 6732821 SGTC_1904 st060225 78 µM -0.12419911103386 0.471491479020794 no 1783 0.450578813041095 598 66595 SGTC_1797 st048695 56.8 µM -0.12478605997507 0.471247920685389 no 1784 0.450346461826216 604 592262 YIL048W NEO1 SGTC_284 0988-0104 32.6 µM -0.125679176941566 0.470877336568388 no 1785 0.449992942772689 604 4666532 SGTC_3341 9147222 25.867 µM -0.126718844959378 0.470445975301757 no 1786 0.449581464978807 634 1939759 SGTC_2873 9040596 71.43 µM -0.127325638073311 0.470194231077378 no 1787 0.449341334598762 599 6463863 SGTC_1154 4088-0362 150 µM -0.127930698331681 0.469943217635392 no 1788 0.44910190844583 596 6618304 SGTC_754 3474-0146 171 µM -0.128186502578392 0.469837099057035 no 1789 0.449000690663896 601 24762078 SGTC_1718 roemerine 11.9335 µM -0.128334514445529 0.469775698361132 no 1790 0.448942126173863 608 235224 An aporphine alkaloid with mutagenic activity. SGTC_1636 st007707 68.9 µM -0.129010869065801 0.469495131077966 no 1791 0.448674524216712 616 403051 SGTC_2977 9011197 71.43 µM -0.12923154957613 0.469403591052289 no 1792 0.448587216284314 594 2704722 SGTC_871 0574-0004 149 µM -0.129817119849287 0.469160699711322 no 1793 0.448355558926402 600 9551173 SGTC_2076 5212012 200 µM -0.131533361146776 0.468448878670335 no 1794 0.447676698720975 604 604802 SGTC_2571 chrysanthemic acid 100 µM -0.131670583626767 0.468391969174415 no 1795 0.447622426881811 658 2743 An insecticide. SGTC_2539 epi(13)torulosol 80 µM -0.133049528593737 0.4678201232498 no 1796 0.447077105252675 636 6708597 SGTC_103 0844-0104 51.839 µM -0.134758283792828 0.467111597881836 no 1797 0.446401494804442 604 5375804 SGTC_1905 st060207 84.5 µM -0.134842775811698 0.467076566444473 no 1798 0.446368092230747 592 1948547 SGTC_2089 5281248 129.67 µM -0.134843902098676 0.467076099473666 no 1799 0.446367646973702 597 2737878 SGTC_2211 7117706 200 µM -0.136009188692101 0.46659298339824 no 1800 0.445907008471481 593 822771 SGTC_504 lovastatin 124 µM -0.137360699412079 0.466032722367302 no 1801 0.445372846931394 647 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2621 lithochol-11-enic acid 100 µM -0.138508289237069 0.465557048373646 no 1802 0.444919359448375 636 6708711 SGTC_1693 xanthone 101.9 µM -0.13944155428332 0.465170247877776 no 1803 0.44455061875949 626 7020 An insecticide. SGTC_2141 5621638 7.665 µM -0.139837126611984 0.465006309105945 no 1804 0.444394339342874 633 2856238 SGTC_193 1273-0060 1.558 µM -0.140508268602715 0.464728178394666 no 1805 0.444129209950208 635 2847393 YHR072W ERG7 SGTC_1034 k072-0165 12.7 µM -0.140951699025615 0.464544424016044 no 1806 0.443954049939654 658 5835461 SGTC_175 3793-3120 23.7 µM -0.141367159736703 0.464372266945353 no 1807 0.443789948213137 646 5322297 SGTC_443 clozapine 122 µM -0.142613323654183 0.463855926291698 no 1808 0.443297787146229 600 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1979 st071809 45.3 µM -0.142713636672926 0.463814364821027 no 1809 0.443258173228407 647 4976333 SGTC_1185 1319-0113 81.3 µM -0.143164551430631 0.463627547687783 no 1810 0.44308011262151 625 4672763 SGTC_387 norethindrone acetate 66.7 µM -0.143362126202614 0.463545693604443 no 1811 0.44300209643082 639 541197 SGTC_300 r073-0011 5.04 µM -0.143475812407195 0.463498594767793 no 1812 0.442957206252394 609 2735780 SGTC_2614 arthonioic acid 13.39 µM -0.144062761047508 0.463255437110521 no 1813 0.44272545514806 627 6710684 SGTC_602 3130-1533 38.1 µM -0.14411405325533 0.463234188724919 no 1814 0.442705203836123 620 720941 SGTC_758 0868-0029 16 µM -0.145462223736931 0.462675731427356 no 1815 0.442172969782169 597 762687 SGTC_941 3237-0776 460 µM -0.147460100021381 0.461848279857249 no 1816 0.441384435482246 607 760008 SGTC_13 0199-0087 65 µM -0.148398778932999 0.46145956816173 no 1817 0.441014031836694 601 4589825 SGTC_2767 sibutramine 71.45 µM -0.148495619697428 0.461419467998959 no 1818 0.440975821303843 651 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2114 5491910 81.25 µM -0.148590515284699 0.461380173682455 no 1819 0.440938378814031 620 2849228 SGTC_562 3772-2733 112 µM -0.1488024881656 0.461292401422014 no 1820 0.440854743613842 625 2876874 YIL048W NEO1 SGTC_547 1120-0019 610 nM -0.149471640171957 0.461015335990475 no 1821 0.440590742911058 619 3676939 SGTC_60 0986-0278 202 µM -0.149818436665578 0.460871750761343 no 1822 0.440453931587361 608 3110598 SGTC_2713 st079149 53.4 µM -0.150615971013835 0.460541564524034 no 1823 0.44013933103689 605 3103253 SGTC_2013 4024628 200 µM -0.151003471797775 0.460381145596205 no 1824 0.439986488603057 628 5230760 SGTC_3032 9089427 49.47 µM -0.15237939290467 0.459811589246526 no 1825 0.43944385467543 599 17173707 SGTC_3179 9107801 49.47 µM -0.15297044614351 0.459566950669705 no 1826 0.439210790759547 609 4818259 SGTC_1552 6-methylflavone 10.6 µM -0.153671309978811 0.459276881027921 no 1827 0.438934453679336 619 689013 SGTC_1325 1431-0015 227 µM -0.153737856361034 0.459249340304341 no 1828 0.438908217270436 618 1103340 SGTC_2226 7298446 200 µM -0.154172659288907 0.459069398643491 no 1829 0.438736799575679 630 3283010 SGTC_2848 9016370 25.97 µM -0.154803260244436 0.458808441567911 no 1830 0.438488210446951 600 7894410 SGTC_510 ag-490 170 µM -0.155375783515624 0.458571533734371 no 1831 0.438262537129273 623 5328779 SGTC_568 1193-0097 7.48 µM -0.156189553475529 0.458234824329924 no 1832 0.437941805399315 616 3646150 SGTC_1315 1237-0019 3.69 µM -0.156376389196895 0.458157522497219 no 1833 0.437868173450611 603 825140 SGTC_1772 st048439 82.2 µM -0.157837847176862 0.457552910409779 no 1834 0.437292287355534 599 2927068 YDL195W SEC31 SGTC_2799 7812892 81.82 µM -0.158584750224491 0.457243950920024 no 1835 0.436998022148831 612 20205235 SGTC_1220 1838-0075 193 µM -0.160016337354102 0.45665184145401 no 1836 0.436434102350085 632 5529645 SGTC_2081 5214970 32.255 µM -0.160925577682633 0.456275826346264 no 1837 0.436076008387892 627 2063512 SGTC_1229 0139-0193 12.2 µM -0.16136399441677 0.456094533669029 no 1838 0.4359033616475 609 3090752 SGTC_575 k072-0246 11.9 µM -0.16196111280007 0.455847629905809 no 1839 0.435668238489743 612 6796779 SGTC_2996 9066192 71.4286 µM -0.162081419866081 0.455797885939211 no 1840 0.435620868761564 633 6472854 SGTC_2102 5377816 72.7585 µM -0.162107863293278 0.455786952335465 no 1841 0.435610457045063 623 1379702 SGTC_3218 9131285 49.47 µM -0.164036491884669 0.454989610168122 no 1842 0.434851208260342 651 17156417 SGTC_1747 st037496 66.6 µM -0.164487799010754 0.454803054836897 no 1843 0.434673575454841 608 723305 SGTC_888 0916-0002 6.97 µM -0.166635482104758 0.453915411481283 no 1844 0.433828436666163 621 2802138 YIL048W NEO1 SGTC_2450 5739737 12.93 µM -0.166909969304696 0.453801981657065 no 1845 0.433720444410025 606 2262825 SGTC_1965 Pectolinarigenin 58.4 µM -0.169238584319897 0.452839851068866 no 1846 0.432804490797789 618 5320438 An anti-inflammatory. SGTC_2025 5147754 141 µM -0.170128661449263 0.452472164326549 no 1847 0.432454476750084 629 315777 YLR208W SEC13 SGTC_3150 9097574 49.47 µM -0.170251790661431 0.45242130342062 no 1848 0.432406061569205 662 17217476 SGTC_1019 4262-0212 3.4 µM -0.171748368097352 0.451803175782581 no 1849 0.431817679253572 618 4677213 SGTC_2303 7774051 200 µM -0.173341416777053 0.451145331261358 no 1850 0.431191535262587 640 2953184 SGTC_2461 5755302 26.15 µM -0.173929918518328 0.450902345127596 no 1851 0.43096026970139 664 2788904 SGTC_2988 9073640 71.4286 µM -0.17467529382744 0.450594613979674 no 1852 0.430667390978804 648 9102229 SGTC_352 k048-0007 5.11 µM -0.178173908838934 0.449150596762023 no 1853 0.429293199789811 669 6811911 SGTC_721 1187-1332 279 µM -0.178626998325958 0.448963637589911 no 1854 0.429115296916348 640 25730 SGTC_3350 9150499 3.57 µM -0.178802260752572 0.448891321760406 no 1855 0.429046485034075 622 4910996 YPR165W RHO1 SGTC_1769 st044406 64.4 µM -0.18110986924065 0.447939328141109 no 1856 0.428140669083696 639 670903 SGTC_1093 fluphenazine 7.97 µM -0.181240575476748 0.447885414784076 no 1857 0.428089373658637 654 6602611 An atypical antipsychotic. SGTC_2325 6158266 200 µM -0.181352010950523 0.447839450939523 no 1858 0.428045641968845 616 3623240 SGTC_221 trifluoperazine 10.304 µM -0.18223980819739 0.447473285840627 no 1859 0.427697266807132 630 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_927 2425-1185 123 µM -0.182427529437554 0.447395867391549 no 1860 0.427623611457265 642 730375 SGTC_3206 9114350 49.47 µM -0.18534212014436 0.446194114812878 no 1861 0.426480351593859 645 17087243 SGTC_1277 0873-0036 22 µM -0.185563681943111 0.446102779871003 no 1862 0.426393468225361 630 5965735 SGTC_324 1315-0088 19.6 µM -0.185871588154562 0.445975855718193 no 1863 0.426272731642502 652 6787421 SGTC_2691 st077356 60.2 µM -0.186158430418074 0.44585761946171 no 1864 0.426160260898801 648 2839272 SGTC_3296 9122258 64.045 µM -0.186218397406445 0.445832901703281 no 1865 0.426136748623902 657 4730474 SGTC_1550 gossypolone 36.6 µM -0.186763326379766 0.445608297403676 no 1866 0.425923101116336 625 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2776 terbinafine 19.92 µM -0.186863744589471 0.445566909762366 no 1867 0.425883733034581 596 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1143 3454-2408 5.08 µM -0.187413998017576 0.445340131841425 no 1868 0.425668024110214 627 X1143 SGTC_2306 7482397 179.52 µM -0.191080837425542 0.443829364383358 no 1869 0.424231130270053 667 891448 SGTC_1168 k815-0004 80.5 µM -0.191145304436874 0.443802810688624 no 1870 0.42420587706692 618 642433 SGTC_1204 4049-0315 18.3 µM -0.191867109018996 0.443505519627596 no 1871 0.423923150970257 636 588402 SGTC_1098 clofazimine 15.1 µM -0.19193809906005 0.443476282535508 no 1872 0.423895346751523 622 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_483 fpl-64176 144 µM -0.191964856986522 0.44346526242225 no 1873 0.423884866742624 631 3423 SGTC_2497 7-hydroxyflavone 100 µM -0.192226353882399 0.443357568584608 no 1874 0.42378245170883 651 5281894 SGTC_126 0417-1624 672.48 µM -0.194121924851536 0.442577029776673 no 1875 0.423040207305322 656 41912 YDL195W SEC31 SGTC_1923 st058458 19.1 µM -0.195189709106217 0.442137446429148 no 1876 0.422622217531396 685 3534982 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.195360159383505 0.44206728236994 no 1877 0.422555501922562 616 5355888 SGTC_2730 imipramine 71.33 µM -0.195370623594144 0.44206297494717 no 1878 0.422551406218752 646 3696 A tricyclic antidepressant. SGTC_138 0850-0259 40.9225 µM -0.195847652946994 0.441866620824997 no 1879 0.422364705291782 645 6813004 SGTC_2817 7995342 71.43 µM -0.197197799707424 0.441310952979669 no 1880 0.421836376194554 667 18879975 SGTC_1525 8-methoxypsoralen 92.5 µM -0.19801658218881 0.44097403017786 no 1881 0.421516044950819 694 4114 Related to psoralen; DNA damaging agent. SGTC_2698 st077697 67.5 µM -0.198105131566873 0.440937595333604 no 1882 0.421481404996825 628 3154499 SGTC_2726 cimetidine 79.27 µM -0.19810885788224 0.440936062101496 no 1883 0.421479947299254 644 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2929 9013348 24.6 µM -0.198480810462664 0.440783022712988 no 1884 0.421334448560998 644 2995952 SGTC_2812 7970281 58.44 µM -0.200819579725911 0.439820942784613 no 1885 0.420419826198154 661 2233435 SGTC_656 4090-1979 187 µM -0.200832766948828 0.439815519069056 no 1886 0.420414670284745 644 22330961 SGTC_1679 SEC14.276 6.7 µM -0.200900068753759 0.439787838978376 no 1887 0.420388356975577 633 1005053 YMR079W SEC14 SGTC_1316 1272-0050 65.9 µM -0.200986367087051 0.439752346368524 no 1888 0.420354617023288 638 7340392 SGTC_2487 5918373 44.05 µM -0.201802185447446 0.439416842152411 no 1889 0.420035686480279 627 2876279 SGTC_456 gingerol 170 µM -0.203803510994191 0.438593984460883 no 1890 0.419253524525402 679 442793 A herb. SGTC_3324 9138759 60.749 µM -0.204439942918047 0.438332366879798 no 1891 0.419004859659629 659 45595710 SGTC_3140 9094243 49.47 µM -0.20516033575975 0.438036268067766 no 1892 0.418723428864467 660 19291112 SGTC_3190 9110366 49.47 µM -0.205250317264408 0.437999285935338 no 1893 0.418688279343185 666 17123768 SGTC_2276 7947513 42.08 µM -0.206200604995276 0.437608753605988 no 1894 0.418317107642207 667 2105100 SGTC_2050 5263056 171 µM -0.210174839022271 0.435976156486524 no 1895 0.416765608262131 657 763468 YGL055W OLE1 SGTC_282 k297-0036 65.7 µM -0.210875313740029 0.435688516916979 no 1896 0.416492283876165 658 5061378 SGTC_2490 carminic acid 95.39 µM -0.211457767713109 0.435449366715083 no 1897 0.416265041776961 668 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2611 pyromycin 23.93 µM -0.2129974545946 0.434817299459172 no 1898 0.415664474035235 640 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_610 4215-0184 155 µM -0.215423829317176 0.433821570629155 no 1899 0.414718446503598 650 5605015 SGTC_2316 5844804 197.44 µM -0.215500188442073 0.433790241367295 no 1900 0.414688682579289 669 776813 SGTC_1724 st037281 8.293 µM -0.216646680268976 0.433319899205671 no 1901 0.414241851991919 640 574124 YDL195W SEC31 SGTC_2273 7815444 169.05 µM -0.216721665095195 0.433289140363024 no 1902 0.414212631471188 707 2824616 SGTC_3356 9151811 4.48 µM -0.217441234395161 0.432993992965155 no 1903 0.41393224971014 633 1859254 YPR165W RHO1 SGTC_449 xestospongin c 11.1929 µM -0.219138022029575 0.432298165929778 no 1904 0.413271266600168 671 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2290 7904846 200 µM -0.219389813523179 0.432194927869182 no 1905 0.413173202193848 655 2962154 SGTC_357 1325-0123 420 µM -0.219812613828554 0.432021584203204 no 1906 0.413008547734963 687 1098503 SGTC_309 k408-0051 1.48 µM -0.222900904359991 0.43075581663857 no 1907 0.411806316259031 649 3640463 SGTC_970 1315-0089 19.5 µM -0.224002652096096 0.430304425418482 no 1908 0.411377619797744 620 6811083 YLR033W RSC58 SGTC_2444 5485484 36.41 µM -0.224118513185637 0.43025696186762 no 1909 0.411332543711676 687 6790631 SGTC_157 1348-1695 65.819 µM -0.224593127771155 0.430062542204782 no 1910 0.411147905782728 635 5380510 SGTC_1061 3448-9325 110 µM -0.224725908839037 0.430008153208867 no 1911 0.41109625387233 662 723482 SGTC_1413 3910-0535 34.4 µM -0.225216485824915 0.429807217490585 no 1912 0.410905432520803 640 2876951 SGTC_1698 5-fluorocytosine 1.055 µM -0.225506484689499 0.429688445230577 no 1913 0.410792640615872 631 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2851 9015922 71.43 µM -0.226443859334519 0.42930457660141 no 1914 0.410428109439456 636 2996893 SGTC_1476 4112-3294 3.34 µM -0.227113017749038 0.429030587310423 no 1915 0.410167930910788 644 704369 SGTC_2249 haloperidol 116.36 µM -0.227520401779167 0.428863799207511 no 1916 0.410009553427153 662 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1075 aripiprazole 15.2 µM -0.227667019233362 0.428803775299921 no 1917 0.409952556984301 645 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2517 totarol 10 µM -0.228048509527669 0.428647604218545 no 1918 0.40980426439303 650 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_538 2922-0838 53.3 µM -0.228302382057644 0.42854368234448 no 1919 0.409705586421267 653 777039 SGTC_3276 9139060 49.47 µM -0.229557815127028 0.428029847967234 no 1920 0.409217695052156 679 4870619 SGTC_1870 st057514 26.5 µM -0.230004488382263 0.427847059103056 no 1921 0.409044140994083 627 5393161 SGTC_400 oxethazaine 37.5 µM -0.230237057631601 0.427751892599187 no 1922 0.408953783703463 664 4621 A local anesthetic. SGTC_3333 9141820 12.094 µM -0.230257299351135 0.427743609958792 no 1923 0.40894591966414 667 1939433 SGTC_3160 9100216 49.47 µM -0.230466366446099 0.427658064368502 no 1924 0.40886469788664 641 17191039 SGTC_839 0122-0028 230 µM -0.231836631338552 0.427097466916807 no 1925 0.408332452179998 653 759448 SGTC_3154 9100113 49.47 µM -0.232044288511134 0.427012523836752 no 1926 0.408251807584721 661 25237525 SGTC_264 promethazine 12.5 mM -0.233058482059237 0.426597712202399 no 1927 0.407857996862019 643 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2991 9074669 71.4286 µM -0.234287347444186 0.426095207223617 no 1928 0.407380953943319 676 17333109 SGTC_932 2857-0803 154 µM -0.235626562094687 0.425547715102739 no 1929 0.406861230073836 666 674898 SGTC_1424 4048-1941 275 µM -0.236031795749768 0.425382077414268 no 1930 0.406703998834086 671 X1424 SGTC_1788 fluconazole 20 µM -0.23605440165298 0.425372837726342 no 1931 0.40669522815382 663 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2597 laccaic acid a 100 µM -0.236104632122635 0.425352307224073 no 1932 0.406675739810559 674 5491415 A textile dye. SGTC_1795 st049545 62.3 µM -0.236195945005201 0.42531498578726 no 1933 0.406640312965554 624 5291882 SGTC_1707 st032323 6.317 µM -0.236896268929133 0.425028771394511 no 1934 0.406368632288934 656 3132057 YMR211W DML1 SGTC_2403 6032726 181.2 µM -0.23702527202738 0.4249760536062 no 1935 0.406318592289001 659 2881040 SGTC_1288 0973-0013 65.5 µM -0.237122528027947 0.424936310321749 no 1936 0.406280867925498 639 4315430 SGTC_951 1171-0579 82.7 µM -0.237406125662188 0.424820423614617 no 1937 0.406170868984774 662 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2315 7733312 200 µM -0.238464393967284 0.424388040105171 no 1938 0.405760464178242 655 726316 SGTC_1838 st055369 84.5 µM -0.239194436761253 0.424089814808272 no 1939 0.405477408150671 633 676036 SGTC_3075 9116269 49.47 µM -0.239390978309116 0.424009534246492 no 1940 0.405401212467193 677 17015205 YNL244C SUI1 SGTC_736 0958-0254 92.6 µM -0.241052682739978 0.423330910656112 no 1941 0.4047571425968 692 6812352 SGTC_902 1120-0002 2.07 µM -0.241082077829021 0.423318908034463 no 1942 0.404745751496821 674 3280475 SGTC_3149 9097855 49.47 µM -0.2414047435006 0.423187161660153 no 1943 0.404620718336366 638 25236625 YMR079W SEC14 SGTC_804 1595-0054 20.9 µM -0.241546512877495 0.423129279068291 no 1944 0.404565785688122 682 761523 Stimulates phospholipase C. SGTC_1409 3909-8004 61.9 µM -0.241984357162199 0.422950523424777 no 1945 0.404396142128244 637 2119279 SGTC_1883 5-benzylidenerhodanine 20 µM -0.243076470708297 0.422504723019704 no 1946 0.403973079151134 635 1273210 SGTC_735 3076-0345 636 µM -0.245022530005236 0.421710588567732 no 1947 0.403219493281532 639 2888990 SGTC_1332 1480-0653 17.5 µM -0.245238315815482 0.421622551727205 no 1948 0.40313595514109 674 5749438 SGTC_1074 carmofur 3.8 µM -0.24601169189683 0.421307060007514 no 1949 0.402836590886657 660 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1341 1486-1360 280 µM -0.247113248373249 0.420857777355249 no 1950 0.402410290457411 661 3976547 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.247565485324316 0.420673357048491 no 1951 0.402235309115936 691 689007 SGTC_1458 k015-0034 6.33 µM -0.248457057718769 0.420309828644183 no 1952 0.401890395747493 689 3598957 SGTC_1620 st003704 16.5 µM -0.249150046244799 0.420027317459311 no 1953 0.401622359215031 635 2834414 SGTC_2353 9059630 146.67 µM -0.250017407515577 0.41967377767232 no 1954 0.401286943400456 664 4779114 SGTC_1329 1447-1697 50.6 µM -0.250138763823066 0.419624317537987 no 1955 0.401240019701774 649 2840515 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.251143499041648 0.41921487519097 no 1956 0.400851582986816 667 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2163 5671233 125 µM -0.251316856791764 0.419144238544217 no 1957 0.400784571734956 628 701023 SGTC_677 0929-0063 136 µM -0.251989477691857 0.418870195968248 no 1958 0.400524598505195 653 1539583 SGTC_3352 9151559 45.5865 µM -0.252272995407111 0.418754695545507 no 1959 0.400415029888189 643 17159339 SGTC_2467 5474540 200 µM -0.253803912502338 0.41813114651599 no 1960 0.399823525330166 649 5413519 SGTC_17 0960-0276 49.807 µM -0.254899032195651 0.41768522573631 no 1961 0.399400541890077 660 6821114 SGTC_3045 9092950 49.47 µM -0.254942415418673 0.417667562737057 no 1962 0.399383787807256 692 44120432 SGTC_2702 st077768 96.8 µM -0.256540684760462 0.417016961126214 no 1963 0.398766684676576 643 6484119 SGTC_2310 7668677 200 µM -0.25661101232481 0.416988338349043 no 1964 0.398739536504927 684 2197143 SGTC_1272 0839-0021 27 µM -0.256722557735898 0.416942941128054 no 1965 0.398696478234293 679 5027250 SGTC_1547 harmine 94.2 µM -0.258837548813155 0.416082383393295 no 1966 0.397880292546583 631 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_332 4112-0506 40.9 µM -0.25916935878485 0.4159474113496 no 1967 0.397752285860367 646 2790355 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.259394011680543 0.415856033766371 no 1968 0.397665624813716 682 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2082 5219693 150 µM -0.261084321458188 0.41516864634425 no 1969 0.397013741072243 682 2834649 SGTC_1192 1488-0095 21.4 µM -0.261399426770721 0.415040533134168 no 1970 0.396892249522248 687 915875 SGTC_3021 9087658 49.47 µM -0.262365853646274 0.414647666771679 no 1971 0.396519697826512 650 25237042 SGTC_1981 st071826 47 µM -0.262636618999039 0.414537612069917 no 1972 0.396415336350538 645 11838600 SGTC_842 0271-0008 11.1 µM -0.262746863255069 0.414492804348509 no 1973 0.396372846875276 663 1221709 SGTC_1435 4092-0789 56.7 µM -0.263604048960365 0.414144447436552 no 1974 0.396042519118019 666 2248285 SGTC_2258 7960471 200 µM -0.263824461766201 0.414054883440611 no 1975 0.395957592205069 692 2974708 SGTC_353 1988-1175 58.3 µM -0.26543561527546 0.413400332715985 no 1976 0.395336951397806 681 2788357 SGTC_2279 7948423 32.93 µM -0.26571169171748 0.41328819739699 no 1977 0.395230629148271 647 1247112 SGTC_1035 k081-0041 55.2 µM -0.266577055568019 0.412936754201008 no 1978 0.394897411765223 657 731709 SGTC_2297 7971671 152.32 µM -0.266752459787066 0.412865527204238 no 1979 0.39482987990076 688 909016 SGTC_2368 9071271 200 µM -0.26698581505574 0.412770772271811 no 1980 0.394740041370839 693 27209959 SGTC_2266 7929956 200 µM -0.267523829359315 0.412552328575463 no 1981 0.394532934688944 659 2967153 SGTC_1914 st062367 72.6 µM -0.267942699181536 0.412382278475177 no 1982 0.394371712882854 676 978205 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.268488245192123 0.412160825847057 no 1983 0.394161760903892 705 5282309 SGTC_1130 3454-2858 15.9 µM -0.269334181112454 0.411817491746919 no 1984 0.393836265470738 696 715628 YIL048W NEO1 SGTC_147 4466-0538 29.23 µM -0.269355384927361 0.411808886768805 no 1985 0.393828107713567 679 6742687 YHR072W ERG7 SGTC_3077 9117319 49.47 µM -0.270545482974416 0.411325986709223 no 1986 0.393370315330672 664 17154678 SGTC_39 0986-0283 58.349 µM -0.271344321167633 0.411001921469647 no 1987 0.393063110635224 646 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2342 7990637 118.86 µM -0.271802854027656 0.410815935547954 no 1988 0.392886805307322 714 2033102 YER133W GLC7 SGTC_1928 4'-methoxychalcone 40.3 µM -0.273329422958355 0.410196887271696 no 1989 0.392299999939303 703 641818 SGTC_121 0557-0495 61.343 µM -0.273961642617051 0.409940577444859 no 1990 0.392057049514938 678 3104427 SGTC_290 2043-6722 48.1 µM -0.274831128984546 0.409588139564681 no 1991 0.391722990588288 678 773758 YLR208W SEC13 SGTC_2066 5222451 176 µM -0.275585367905987 0.409282475275931 no 1992 0.391433274671774 683 2281147 SGTC_2336 9001819 198.65 µM -0.276643337179138 0.408853813618129 no 1993 0.391026992295675 685 2989602 SGTC_2005 4024620 188 µM -0.277234900983032 0.408614174815916 no 1994 0.390799871194394 684 236743 SGTC_943 3253-1379 105 µM -0.277704279558418 0.408424056790099 no 1995 0.390619687579918 699 668464 SGTC_875 0709-0210 25.7 µM -0.278548295160593 0.408082249289442 no 1996 0.390295748554813 699 6251364 SGTC_1961 st076550 68.7 µM -0.279071920770884 0.407870227728129 no 1997 0.39009481568668 673 1579337 SGTC_961 1252-1571 372 µM -0.279213171070473 0.407813038601827 no 1998 0.390040618192389 699 6813498 SGTC_2051 5263410 176 µM -0.280224155820447 0.407403770619037 no 1999 0.389652767560167 650 227584 SGTC_2874 9043904 71.43 µM -0.2809786368223 0.407098406595762 no 2000 0.389363392691426 671 4463428 SGTC_333 3486-0131 40.1 µM -0.281204415608728 0.407007037239115 no 2001 0.389276809046456 654 6744690 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.281711653082086 0.40680178415194 no 2002 0.389082309189507 676 4213774 SGTC_662 k832-1615 104 µM -0.282079730523504 0.406652858042638 no 2003 0.388941187547782 680 5878478 SGTC_530 4358-1714 28 µM -0.282656189345461 0.406419646842219 no 2004 0.38872020150799 654 1564641 SGTC_2871 9038510 12.99 µM -0.283754800081179 0.405975286720672 no 2005 0.388299147783371 732 4945164 SGTC_1906 st060206 94.7 µM -0.284643075806496 0.405616090281509 no 2006 0.387958803019685 692 5133468 SGTC_231 b-estradiol 524 µM -0.287009238017796 0.404659662116016 no 2007 0.38705262338554 658 450 A steroid. SGTC_717 1532-0246 73.2 µM -0.287132892777012 0.40460969514059 no 2008 0.387005283648443 679 9561992 SGTC_2521 angolensin 13.4 µM -0.292016413085242 0.402637592004164 no 2009 0.385137037408815 662 821428 A flavenoid. SGTC_2705 st078069 42.8 µM -0.292064544245806 0.40261816751982 no 2010 0.385118637468107 693 1530061 SGTC_1080 nisoldipine 24.4 µM -0.292874668237053 0.402291258663825 no 2011 0.384808976044696 701 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1571 st070080 73.4 µM -0.293552609560607 0.4020177419051 no 2012 0.38454989651707 668 4315245 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.293741817903983 0.40194141398519 no 2013 0.384477598559731 714 6708760 SGTC_1940 st075990 51.1 µM -0.294132928113087 0.401783649351121 no 2014 0.384328165092829 693 1084979 SGTC_549 1661-1316 519 µM -0.294565194216987 0.401609302019668 no 2015 0.384163026982738 699 2857282 SGTC_1198 1612-1005 86.7 µM -0.294867829813504 0.401487250646196 no 2016 0.384047423974114 667 6998509 SGTC_2894 9048625 32.47 µM -0.296131850944026 0.400977581474226 no 2017 0.383564695360118 678 4092861 SGTC_1308 1187-1617 41.4 µM -0.296572201370877 0.400800066187312 no 2018 0.3833965682952 677 2882570 SGTC_3228 9131799 49.47 µM -0.297066580619482 0.400600795059288 no 2019 0.383207839032718 676 17015818 SGTC_2683 piperine 63.03 µM -0.299020218140514 0.399813589274645 no 2020 0.382462309537918 696 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2682 pyrogallin 40.03 µM -0.299600917520725 0.399579678487772 no 2021 0.382240792113694 693 822798 An ATP competetive kinase inhibitor. SGTC_1813 st051246 8.6015 µM -0.299672289541812 0.399550931698964 no 2022 0.382213568728586 663 5291959 SGTC_1861 st057647 17.4 µM -0.302209145905036 0.398529506886756 no 2023 0.381246316298105 697 688668 SGTC_539 4859-0462 2.54 µM -0.303525558928045 0.397999747481938 no 2024 0.380744686198579 661 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_90 0870-0863 4.608 µM -0.303849690271317 0.397869337264758 no 2025 0.380621203977075 695 1738164 SGTC_1614 st002383 48.6 µM -0.304603485526977 0.397566101260389 no 2026 0.380334082519364 682 1947235 SGTC_3009 9080819 71.4286 µM -0.304936158656314 0.397432293518098 no 2027 0.380207387908133 697 17027216 SGTC_1423 4048-0112 5.59 µM -0.308601967013252 0.395958635095839 no 2028 0.378812162196184 680 X1423 SGTC_3174 9107204 49.47 µM -0.308717939312851 0.395912038257428 no 2029 0.378768048189276 700 3938802 SGTC_363 0455-0021 3.06 µM -0.309038865492879 0.395783100174477 no 2030 0.378645981240204 685 4597466 SGTC_1691 st019933 84.6 µM -0.309338393296947 0.395662769576569 no 2031 0.378532064263638 704 6176082 SGTC_2330 7979373 200 µM -0.310202339724711 0.395315748394923 no 2032 0.37820354569539 669 1863007 SGTC_279 1273-0055 2.93 µM -0.310951203552678 0.395015019556134 no 2033 0.377918858891575 699 2847562 SGTC_2984 9022109 38.96 µM -0.311217152738332 0.394908234682802 no 2034 0.377817772042383 701 6459207 SGTC_811 0416-0114 265 µM -0.31328764611949 0.394077153275455 no 2035 0.377031067518826 712 6612453 SGTC_1845 st056753 3.01 µM -0.313921151017576 0.393822965029672 no 2036 0.376790462822198 670 5375839 SGTC_107 0358-0022 2.6945 µM -0.314400087275204 0.393630826103137 no 2037 0.376608594935616 723 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2598 perillyl alcohol 100 µM -0.31451136000141 0.39358618958392 no 2038 0.376566344931723 679 10819 An apoptosis inducer. SGTC_1414 3917-0015 5.4 µM -0.314621196045318 0.393542130754307 no 2039 0.376524641882931 703 6618702 SGTC_1101 ebselen 5.29 µM -0.315479915176103 0.393197717452182 no 2040 0.37619864920883 704 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2092 5303694 80.6725 µM -0.318017165950173 0.392180571360282 no 2041 0.375235957900889 699 1963699 SGTC_1159 4092-0538 61.2 µM -0.321355250496186 0.390843505363129 no 2042 0.373970595495833 676 717301 SGTC_2123 5259487 200 µM -0.322452432628071 0.390404311080196 no 2043 0.373554984027301 686 2173474 SGTC_1006 4099-6547 255 µM -0.322507647708684 0.390382212562688 no 2044 0.373534072492857 687 3146833 SGTC_2752 diclazuril 33.15 µM -0.322557967971207 0.390362073387676 no 2045 0.373515015090713 690 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2213 7173844 200 µM -0.323986216792085 0.389790582526847 no 2046 0.372974234659137 685 892728 SGTC_322 k048-0136 19.3 µM -0.325127939386526 0.38933391177553 no 2047 0.372542122052238 679 6823282 SGTC_1634 st006576 41 µM -0.325172276359577 0.389316180774474 no 2048 0.372525344881033 710 3915356 SGTC_427 1354-0053 47.3 µM -0.326110510593343 0.388941021335371 no 2049 0.372170372527371 718 6813657 SGTC_2990 9074105 71.4286 µM -0.326663237149289 0.388720058242148 no 2050 0.3719613042959 706 6502001 SGTC_2909 7941780 10.49 µM -0.327038224120271 0.38857017046431 no 2051 0.371819487359895 705 1243215 SGTC_3233 9132340 49.47 µM -0.327990903711493 0.388189445155256 no 2052 0.371459270162835 736 17682950 SGTC_318 1488-0629 67.2 µM -0.328239879486603 0.388089963098938 no 2053 0.371365148595861 708 3662576 SGTC_2839 9003951 25.97 µM -0.328764637653718 0.387880312050656 no 2054 0.371166796817634 712 2990634 SGTC_1832 st054113 55 µM -0.329531020880651 0.387574185839511 no 2055 0.37087717539264 701 1251267 SGTC_2720 fluspirilene 36.88 µM -0.330845647236022 0.387049230734106 no 2056 0.370380539573863 702 3396 An atypical antipsychotic. SGTC_1282 0886-0010 32.4 µM -0.331516747597852 0.386781327263803 no 2057 0.370127096394433 678 2836211 YNL267W PIK1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.331612145921157 0.386743248599822 no 2058 0.37009107348972 706 521171 SGTC_2569 tetrandrine 100 µM -0.331675916048572 0.386717795078536 no 2059 0.370066994192294 674 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.333850006372191 0.38585031018844 no 2060 0.369246373240881 654 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3033 9090887 49.47 µM -0.334764993485261 0.385485391043616 no 2061 0.36890118473397 678 19325384 SGTC_1147 3809-1045 12.3 µM -0.334787384552306 0.385476462209925 no 2062 0.368892738792681 674 325925 SGTC_2405 ticlatone 3.52 µM -0.335522741363223 0.385183259441651 no 2063 0.36861539639734 699 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3299 9121982 43.1275 µM -0.335791774720893 0.3850760063732 no 2064 0.368513946612563 700 17594604 YPL160W CDC60 SGTC_713 1488-1073 324 µM -0.336012399674575 0.384988058401002 no 2065 0.368430757991146 708 3312542 SGTC_1555 citronellol 128 µM -0.336654155953138 0.384732268028165 no 2066 0.368188813090271 703 8842 A terpine precursor. SGTC_3282 9108498 15.4605 µM -0.337673225364996 0.384326191802374 no 2067 0.367804726931269 708 16459645 SGTC_1447 4239-0816 81.9 µM -0.337704929829787 0.38431356032015 no 2068 0.367792779670518 702 1341554 SGTC_359 0081-0058 15.9 µM -0.338899723649068 0.383837628168886 no 2069 0.367342636317049 746 3494159 SGTC_1489 4065-0444 182 µM -0.341241167947304 0.382905449772564 no 2070 0.366461016823118 677 2877968 SGTC_2919 7978188 46.38 µM -0.341339436718121 0.382866341683897 no 2071 0.366424031239111 656 2980291 SGTC_2354 9060492 162 µM -0.341509230422533 0.382798771583757 no 2072 0.366360128618309 714 6471895 SGTC_1350 1495-0454 146 µM -0.341959962623367 0.382619418165594 no 2073 0.366190511514619 703 1069057 SGTC_3171 9103192 49.47 µM -0.344144500217906 0.381750513659915 no 2074 0.365368809076142 703 13018434 SGTC_2997 9067075 71.4286 µM -0.345510501211683 0.381207486127782 no 2075 0.364855308493864 713 27209819 SGTC_42 0133-0086 60.653 µM -0.345967188821154 0.381025990814999 no 2076 0.364683686667209 726 162923 Model of phenazepam hydroxylation. SGTC_876 0720-0963 56.8 µM -0.346003967843761 0.38101137535294 no 2077 0.364669866400716 739 765861 SGTC_2899 9053889 58.44 µM -0.34655258123144 0.380793384333866 no 2078 0.364463737621435 712 6470052 SGTC_1174 0739-0097 51.1 µM -0.347015068323693 0.380609644907131 no 2079 0.36428999924286 698 728447 SGTC_2459 5811157 9.22 µM -0.348624933138151 0.379970279165975 no 2080 0.363685453411776 692 2870684 YBR192W RIM2 SGTC_3099 9120367 49.47 µM -0.349547921038274 0.379603857757859 no 2081 0.363339000506473 707 24824940 SGTC_1387 3342-1166 1.8 µM -0.350134112225173 0.379371199001719 no 2082 0.363119025687707 689 3418228 SGTC_1234 0326-0494 15.5 µM -0.350428354515456 0.379254430960329 no 2083 0.363008624980802 728 1547813 SGTC_3284 9108171 64.8615 µM -0.351620327331955 0.378781517491192 no 2084 0.362561509273856 722 8687505 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.351893124662727 0.3786733110374 no 2085 0.36245920778688 689 688664 SGTC_1378 2093-0007 380 nM -0.353501537946325 0.378035519301759 no 2086 0.36185623799292 720 3618014 SGTC_1689 st020265 53.493 µM -0.354676642045688 0.377569759648379 no 2087 0.361415925849393 716 5758320 YPR016C TIF6 SGTC_3192 9110362 49.47 µM -0.354725526619422 0.377550387801776 no 2088 0.361397612744494 683 16649480 SGTC_3136 9095672 49.47 µM -0.35501104570584 0.377437249225857 no 2089 0.3612906581287 661 17217380 SGTC_3268 9137683 49.47 µM -0.35530268628105 0.377321695832729 no 2090 0.361181421612895 726 1953228 SGTC_2692 st077426 47.7 µM -0.356061966101542 0.377020906657401 no 2091 0.360897079860949 740 25238571 SGTC_719 2810-4230 27.3 µM -0.356201539964005 0.376965622497797 no 2092 0.360844819378358 688 721079 SGTC_1944 st076371 56.9 µM -0.357251027694781 0.376550009141637 no 2093 0.360451944158549 690 24208455 SGTC_451 chloral hydrate 100 µM -0.357400135630769 0.376490971691021 no 2094 0.360396137615211 729 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2483 5729050 27.16 µM -0.358977630908924 0.375866559075841 no 2095 0.359805911718427 729 2865180 SGTC_2736 butenafine 14.65 µM -0.359270399241574 0.375750709645383 no 2096 0.359696408049234 698 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_470 aa-861 153 µM -0.360707890552989 0.375182052096741 no 2097 0.359158912742637 689 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1295 1013-0063 9.78 µM -0.361770617822542 0.37476182181419 no 2098 0.35876172530468 706 6826038 SGTC_1305 1181-0477 144 µM -0.361799335036455 0.374750468334122 no 2099 0.358750994548657 693 6252086 SGTC_448 monastrol 171 µM -0.362607340785537 0.374431064149994 no 2100 0.358449112918366 714 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3145 9085516 49.47 µM -0.362838817618526 0.374339577363992 no 2101 0.358362646402101 689 25236195 SGTC_471 1-acyl-paf 4 µM -0.365031825104474 0.373473184845806 no 2102 0.357543824996692 690 16759367 SGTC_3137 9097352 49.47 µM -0.365688088368213 0.373214038660655 no 2103 0.357298917756507 756 44120435 SGTC_1518 st038567 90.8 µM -0.365811826131278 0.373165183335857 no 2104 0.357252747330524 722 77966 SGTC_2038 4100038 30.985 µM -0.366206994263771 0.37300917294051 no 2105 0.357105311749259 695 3596803 SGTC_2961 9083290 32.55 µM -0.366442564761341 0.372916180794895 no 2106 0.357017431528097 714 17741490 SGTC_454 lyso-paf C-16 6.67 µM -0.366863271356314 0.372750124054492 no 2107 0.356860504650994 734 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1995 st072814 61.1 µM -0.368189392165604 0.37222684691043 no 2108 0.356366009732082 692 5769371 SGTC_3003 9075612 71.4286 µM -0.368322304942587 0.372174413531512 no 2109 0.356316461410742 745 6501993 SGTC_724 3910-0327 137 µM -0.369109918974175 0.371863752674347 no 2110 0.35602289795452 751 2885483 SGTC_2881 9058953 51.95 µM -0.370097723260111 0.371474248124087 no 2111 0.355654839221376 676 17122249 SGTC_2963 9082507 9 µM -0.37173218119464 0.370830048438659 no 2112 0.355046131080414 736 16459611 SGTC_1223 0764-0573 147 µM -0.373416053151189 0.370166751336228 no 2113 0.354419406746412 691 1609797 SGTC_929 2805-0021 398 µM -0.373642792555177 0.370077465439746 no 2114 0.354335046126157 750 3098024 SGTC_689 0833-0039 98 µM -0.373902466832774 0.369975218983761 no 2115 0.354238440542423 745 5374726 SGTC_149 3970-0822 46.1 µM -0.375081558692843 0.369511068582004 no 2116 0.353799905775706 708 3114250 YBL034C STU1 SGTC_184 1494-0393 24.714 µM -0.376128859150046 0.369098957356239 no 2117 0.353410550228065 712 3090647 SGTC_3198 9112019 49.47 µM -0.376766810849806 0.368847997966244 no 2118 0.353173453654679 759 45595555 SGTC_3116 9124943 49.47 µM -0.377339944651673 0.368622584512688 no 2119 0.352960495427321 682 41905195 YPL160W CDC60 SGTC_3068 9116768 49.47 µM -0.377404818765742 0.368597072377761 no 2120 0.352936393177377 730 41904888 SGTC_3058 9093861 49.47 µM -0.37789913235166 0.368402699618717 no 2121 0.352752763509322 741 17217477 SGTC_1732 st034308 51.822 µM -0.378197941566963 0.368285218928364 no 2122 0.352641777249386 676 830119 SGTC_620 0109-0052 432 µM -0.378528017164315 0.368155459772077 no 2123 0.352519192343161 712 493037 SGTC_5 0352-0601 109.883 µM -0.379506007113178 0.367771081194005 no 2124 0.352156072154513 715 762456 SGTC_3212 9128307 49.47 µM -0.380391538425953 0.367423155751661 no 2125 0.351827397384067 717 27243542 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.380614826691749 0.367335442909867 no 2126 0.351744538933467 721 91467 include heat shock SGTC_232 clozapine 119 µM -0.380660019893854 0.367317690807507 no 2127 0.351727769367025 701 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1643 st009866 20.2 µM -0.381040952106145 0.367168070115496 no 2128 0.351586430636419 713 3156273 YOR207C RET1 SGTC_2993 9054257 71.4286 µM -0.381324989104241 0.367056520577048 no 2129 0.351481056656052 728 6470217 YGL055W OLE1 SGTC_1123 mangostin 811.285 nM -0.381943916434661 0.366813488807207 no 2130 0.351251482317381 696 5281650 An antioxidant. SGTC_1085 doxorubicin 7.67 µM -0.382080028840555 0.36676004923865 no 2131 0.35120100238136 727 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2499 avocadenofuran 51.48 µM -0.382514662046208 0.366589423665972 no 2132 0.351039827773224 727 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1195 1502-0147 41.1 µM -0.383286377825822 0.366286533311631 no 2133 0.350753719200797 706 817940 SGTC_2190 6049624 200 µM -0.383972128673184 0.366017453169029 no 2134 0.350499552561126 731 2265554 SGTC_272 doxorubicin 8.13 µM -0.384568271926884 0.365783587463679 no 2135 0.350278652440279 689 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2560 caryophyllene 100 µM -0.385925140328709 0.365251476985925 no 2136 0.349776055485063 702 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2170 morpholine 200 µM -0.386038458716305 0.365207049684817 no 2137 0.349734093170732 716 121171 Reacts with secondary amines. SGTC_711 k292-0785 179 µM -0.386732754551152 0.364934885450861 no 2138 0.349477032359657 716 4146315 SGTC_2659 sanguinarine 24.21 µM -0.386769933031213 0.364920313390392 no 2139 0.349463269092174 736 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1259 0671-0132 43 µM -0.386919937013018 0.364861521492263 no 2140 0.349407740458863 707 X1259 SGTC_695 3505-6186 243 µM -0.387699355583838 0.36455609079431 no 2141 0.349119266365586 735 1819379 SGTC_77 0828-0286 12.516 µM -0.388055676889514 0.364416487811375 no 2142 0.348987415715098 702 745345 SGTC_1768 st044301 37.178 µM -0.388678605362069 0.364172474120756 no 2143 0.348756955409919 759 3931349 SGTC_2750 bromebric acid 70.15 µM -0.388680621946967 0.364171684272981 no 2144 0.348756209439266 729 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_953 1188-0045 9.7 µM -0.390325874091937 0.363527471121594 no 2145 0.348147796448754 715 6144426 SGTC_1515 3460-0031 42.1 µM -0.39032758121517 0.363526802882278 no 2146 0.34814716535849 718 2876596 SGTC_1881 5652484 16 µM -0.390334640247279 0.363524039686762 no 2147 0.348144555776044 736 2255129 SGTC_2239 6685329 187.64 µM -0.392733627772001 0.362585389375546 no 2148 0.347258115425006 708 805680 SGTC_3025 9087895 49.47 µM -0.394199141197931 0.362012384567141 no 2149 0.346717009846186 705 17173641 SGTC_1889 st059080 5.18 µM -0.394376267415952 0.361943150453184 no 2150 0.346651631399458 720 176925 Isolated from Daphnopsis sellowiana. SGTC_394 menadione 8.33 µM -0.394855587181291 0.361755819260542 no 2151 0.346474734241201 738 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1671 st016596 74.5 µM -0.396231091435231 0.361218418866059 no 2152 0.345967278343189 699 2829167 SGTC_3274 9138298 49.47 µM -0.396712756886937 0.361030300029081 no 2153 0.345789645941691 717 17015756 SGTC_841 0251-0215 91.2 µM -0.396790893927479 0.360999786062079 no 2154 0.345760833143322 739 3888614 SGTC_2968 9090663 33.37 µM -0.397362682312573 0.360776519000787 no 2155 0.345550015094355 744 25236811 SGTC_1038 k292-0204 154 µM -0.397980083387991 0.360535494754066 no 2156 0.345322433451667 731 4454212 SGTC_2731 amoxapine 43.43 µM -0.398362329395093 0.360386299328156 no 2157 0.345181560884065 733 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_497 capsazepine 133 µM -0.399881429181426 0.359793585857787 no 2158 0.344621925517087 695 2733484 A calcium channel blocker. SGTC_2913 7966556 36.57 µM -0.400059543877656 0.359724112155339 no 2159 0.344556330418647 740 2976516 SGTC_2979 9012552 45.46 µM -0.400204761575256 0.359667473369116 no 2160 0.344502853904185 730 17100905 SGTC_2216 7189485 200 µM -0.40026003204906 0.359645917215715 no 2161 0.344482501331631 713 731273 SGTC_1005 4092-0690 4.4 µM -0.400361292399161 0.359606425612713 no 2162 0.3444452148038 734 1529343 SGTC_2260 7964312 200 µM -0.400615986707141 0.359507101294037 no 2163 0.344351436837917 723 231951 SGTC_1134 3477-0009 42.5 µM -0.401458295760669 0.35917868975984 no 2164 0.344041368399715 743 3973534 SGTC_2561 acetosyringone 100 µM -0.40167408567165 0.359094571223957 no 2165 0.343961949286298 744 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2375 9072683 200 µM -0.403102060676333 0.35853809489663 no 2166 0.343436572363122 752 16798029 SGTC_3169 9102970 49.47 µM -0.403146480044293 0.358520789649838 no 2167 0.343420234546355 694 17027839 SGTC_882 0843-0131 351 µM -0.403465562217432 0.3583964876476 no 2168 0.34330288204287 704 5425421 SGTC_3257 9139206 32.98 µM -0.403503860429328 0.358381569162257 no 2169 0.343288797686292 728 4910041 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.404343847538036 0.358054419370344 no 2170 0.342979943045759 709 5377381 SGTC_981 1488-1094 54.9 µM -0.40488510671417 0.357843670340408 no 2171 0.342780983154727 703 3449522 SGTC_2433 5607874 27.82 µM -0.405094769758633 0.357762045887418 no 2172 0.342703925436217 718 2252428 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.405174452729454 0.357731026012857 no 2173 0.342674641171337 751 5393153 SGTC_1065 prochlorperazine maleate 2.48 µM -0.405367013891039 0.357656067538006 no 2174 0.342603876979507 747 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1228 0124-0032 52.5 µM -0.405737465404816 0.357511876950923 no 2175 0.3424677554996 711 X1228 SGTC_2002 4023503 131 µM -0.407845313264314 0.356691828402138 no 2176 0.341693621930012 765 4736863 YCR052W RSC6 SGTC_2655 perillic acid 100 µM -0.408520871496824 0.356429145454961 no 2177 0.341445655321821 725 5702197 An apoptosis inducer. SGTC_2115 tiliquinol 12.7705 µM -0.409073493968668 0.356214315276635 no 2178 0.341242863698606 756 71208 A bioactive hydroxyquinoline. SGTC_1485 3909-9022 254 µM -0.409144965544656 0.356186534266197 no 2179 0.341216639669872 733 714516 SGTC_144 4161-2749 112.381 µM -0.410174520717524 0.35578643080801 no 2180 0.340838965063795 710 797501 YMR168C CEP3 SGTC_1973 st070275 50.2 µM -0.41079265299081 0.355546289874941 no 2181 0.340612290457872 728 17118334 SGTC_3256 9138902 49.47 µM -0.411417274444579 0.355303686165753 no 2182 0.340383294672256 741 17228773 SGTC_45 0kpi-0036 14.9 µM -0.411969508680617 0.355089246563544 no 2183 0.340180886152774 744 2795021 SGTC_2664 lyso-paf C-16 73.48 µM -0.412077237561397 0.355047419411143 no 2184 0.340141406021322 733 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2544 sphondin 68.51 µM -0.414887325301334 0.353956984320062 no 2185 0.33911219439016 696 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2379 9035213 200 µM -0.415268646728512 0.353809107202545 no 2186 0.338972625368909 737 646551 SGTC_2727 riluzole 51.77 µM -0.416458134703814 0.353347963463515 no 2187 0.338537398053472 727 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1312 1218-2183 165 µM -0.416498594785266 0.353332281576705 no 2188 0.338522597712821 735 6744073 SGTC_709 3807-1509 243 µM -0.416699147289263 0.35325455328758 no 2189 0.338449239076895 759 1886677 YPL242C IQG1 SGTC_3323 9138564 53.9225 µM -0.416875007261139 0.353186400139098 no 2190 0.338384917586519 705 43912313 YNL103W MET4 SGTC_999 SEC7.066 22.7 µM -0.418138314176612 0.352696954003509 no 2191 0.337922996714387 707 740511 YDR170C SEC7 SGTC_986 1493-0483 84 µM -0.418359980132807 0.352611098523543 no 2192 0.337841970977998 744 40079 SGTC_1761 st044296 37 µM -0.418384053712674 0.352601774815792 no 2193 0.337833171795118 723 1826700 SGTC_2155 5570423 76 µM -0.419717532837971 0.352085456221843 no 2194 0.337345907677778 741 797402 SGTC_2195 6536160 144.242 µM -0.41980862618824 0.352050195120997 no 2195 0.337312631367096 712 3834386 SGTC_2194 5927483 104.545 µM -0.420201614221408 0.351898088935855 no 2196 0.337169087817244 701 760979 SGTC_2942 9052777 62.25 µM -0.420383219584154 0.351827806507819 no 2197 0.337102762306271 749 6469503 SGTC_1033 k072-0102 21.3 µM -0.42066675586464 0.351718086291456 no 2198 0.336999219934309 762 5965931 SGTC_2638 epoxomicin 18 µM -0.421361108859489 0.351449444236608 no 2199 0.336745706820181 720 9915668 A protesome inhibitor. SGTC_2107 5363541 170.161 µM -0.423537918744078 0.350607727649906 no 2200 0.335951419518206 708 244052 SGTC_2381 9035592 200 µM -0.423927860938908 0.350457024282657 no 2201 0.335809212312321 728 4749657 SGTC_1300 1094-0077 113 µM -0.426657389749249 0.349402786597984 no 2202 0.334814445271154 704 5532636 SGTC_2210 7115885 190.385 µM -0.427336190670231 0.349140790291746 no 2203 0.334567238229258 747 2927039 SGTC_3093 9117344 49.47 µM -0.427559987409434 0.349054427375121 no 2204 0.334485751208236 698 24824913 SGTC_134 0269-0018 6.916 µM -0.428197410148199 0.348808489493608 no 2205 0.334253700843351 689 4378915 SGTC_2591 skatole 100 µM -0.429291560522385 0.348386479749456 no 2206 0.333855528897668 759 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1066 ketoconazole 628 nM -0.429798170976753 0.348191145485649 no 2207 0.333671231741166 755 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1044 1222-0021 1.78 µM -0.430204570798449 0.348034478631486 no 2208 0.333523418686788 756 4306703 SGTC_2516 gossypol 71.55 µM -0.430616029325263 0.34787588807067 no 2209 0.333373792038865 750 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2804 7954240 19.48 µM -0.4315906247165 0.347500350994602 no 2210 0.333019486800522 716 828705 SGTC_2809 7964133 12.99 µM -0.431703132719273 0.347457008347191 no 2211 0.332978595133284 748 1253665 SGTC_1701 st028638 40.4 µM -0.43322489248326 0.34687096087028 no 2212 0.332425698252985 734 3490878 SGTC_1345 1488-0192 31.4 µM -0.433918739299794 0.346603873793557 no 2213 0.33217372564039 755 658348 SGTC_918 glabranin 770.725 nM -0.433943420604057 0.346594374458035 no 2214 0.332164763945057 731 124049 Also referred to as licorice root. SGTC_2854 9024559 71.43 µM -0.434698052570286 0.346303978443162 no 2215 0.331890806066992 758 3163529 SGTC_389 tpck 16.7 µM -0.436239169280293 0.345711209646277 no 2216 0.33133160589413 724 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2566 crystal violet carbinol 226 nM -0.436470271386056 0.345622352043717 no 2217 0.331247781977074 765 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2546 rhodinyl acetate 100 µM -0.437030439068215 0.34540700567452 no 2218 0.331044636533938 726 6708682 SGTC_1559 coumarin 343 70.1 µM -0.437872183367595 0.345083506342056 no 2219 0.330739470529998 752 108770 A hepatotoxic, DNA x-linker. SGTC_270 tamoxifen 5.46 µM -0.439701283570126 0.344380936650228 no 2220 0.330076736407549 732 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2415 st077333 57.7 µM -0.439920979722073 0.344296585931789 no 2221 0.329997170157099 756 2766255 SGTC_2087 5276107 200 µM -0.4406301059662 0.344024374996771 no 2222 0.329740401954321 730 144405 SGTC_1608 st001473 40.5 µM -0.440996402094747 0.343883797246702 no 2223 0.329607800850723 759 7292267 SGTC_178 4092-0806 87.505 µM -0.442318661933874 0.343376517788691 no 2224 0.329129314219544 720 2169044 SGTC_3187 9109394 49.47 µM -0.442449420016335 0.343326368306233 no 2225 0.32908201193641 729 17098090 SGTC_398 bronopol 33.3 µM -0.443698843395451 0.34284731775369 no 2226 0.328630165898106 723 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_331 k048-0133 24.5 µM -0.444238032344652 0.342640661344123 no 2227 0.328435248955058 720 6813582 SGTC_133 0724-0033 378.92 µM -0.444865629144261 0.342400179921881 no 2228 0.328208431346054 728 280309 SGTC_3250 9135583 49.47 µM -0.445098280733909 0.342311049125379 no 2229 0.328124365614954 726 7699353 SGTC_3013 9080133 71.4286 µM -0.445232636313568 0.342259580363921 no 2230 0.328075821877807 736 17050193 SGTC_2070 5230947 200 µM -0.450440963061519 0.340266647693388 no 2231 0.326196256992278 772 2835538 SGTC_3263 9137018 49.47 µM -0.451646339338667 0.339806050815031 no 2232 0.325761890647121 744 43844957 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.452503463117899 0.339478673139157 no 2233 0.325453163482142 765 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2437 5741531 144.16 µM -0.452554271812925 0.339459270602238 no 2234 0.325434866469908 751 2262990 SGTC_1497 4476-2978 41.3 µM -0.453474708367801 0.339107853225615 no 2235 0.325103475635213 752 1528379 SGTC_2413 inermin 26.06 µM -0.454239646271446 0.338815910788267 no 2236 0.324828175215266 761 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_706 4262-0057 46.9 µM -0.455324775203066 0.338401931900693 no 2237 0.324437802451103 744 883298 SGTC_2240 6690706 185.951 µM -0.457264113630264 0.337662556869477 no 2238 0.323740610192731 707 805876 SGTC_3005 9076496 71.4286 µM -0.457702769854845 0.337495405401437 no 2239 0.323582998884196 752 21368410 SGTC_380 3970-0968 6 µM -0.458556262789228 0.337170270869584 no 2240 0.323276425430526 744 2891601 SGTC_1983 st071813 46.9 µM -0.460165641725074 0.336557515690152 no 2241 0.322698665308438 736 11838595 SGTC_1374 2889-5571 141 µM -0.460418842447321 0.33646115145678 no 2242 0.322607806246741 737 2853281 SGTC_991 3996-0057 64.7 µM -0.460721673302259 0.336345912876665 no 2243 0.322499151716923 727 715343 SGTC_579 4491-1009 110 µM -0.462166923791633 0.335796152390127 no 2244 0.321980810413329 778 1271041 SGTC_1474 0330-0125 5.35 µM -0.465946670447035 0.334360033007256 no 2245 0.320626836877333 748 X1474 SGTC_1392 3455-1037 33.9 µM -0.467020510592804 0.333952466795711 no 2246 0.32024260186256 749 981132 SGTC_2666 tannic acid 100 µM -0.467591410146926 0.333735866765313 no 2247 0.320038404435033 760 16134267 A thiamine antagonist. SGTC_1405 3909-7894 12 µM -0.469526002242439 0.333002292290092 no 2248 0.319346851641627 752 7104060 SGTC_327 1273-0057 3.96 µM -0.469631487026049 0.332962312041029 no 2249 0.319309162347488 760 3108138 SGTC_787 4152-0075 138 µM -0.470265935802013 0.33272188690441 no 2250 0.31908251571702 712 9566539 SGTC_253 dyclonine 31.25 µM -0.470371033844802 0.332682066510625 no 2251 0.319044977655834 738 3180 An oral anasthetic. SGTC_2431 5490079 200 µM -0.470404972118139 0.332669208107171 no 2252 0.319032856256693 797 5722345 SGTC_2508 celastrol 40.54 µM -0.471014143972725 0.332438440889512 no 2253 0.318815317259895 716 122724 Celastrol is a natural product and antioxidant. SGTC_660 4031-1742 102 µM -0.471172411076814 0.332378496342253 no 2254 0.318758809319524 737 6738706 SGTC_214 4373-3496 70 µM -0.471795648735638 0.33214248330267 no 2255 0.318536328525283 762 3779166 SGTC_407 eburnamonine 100 µM -0.472328684402489 0.331940681542174 no 2256 0.318346099555232 756 3195 SGTC_2735 sertaconazole 140 nM -0.473017985568191 0.331679791564693 no 2257 0.318100173797721 752 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2344 7990960 76.95 µM -0.473344330271178 0.331556303533148 no 2258 0.317983769966024 765 140813 SGTC_1026 k007-1105 30.6 µM -0.474020609962855 0.331300459250771 no 2259 0.317742605134888 737 7066794 SGTC_2780 5215298 71.43 µM -0.475114151781528 0.330886926563492 no 2260 0.317352806061066 773 2834131 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.47735410395176 0.330040512869822 no 2261 0.316554995142736 783 6710655 SGTC_931 2812-0076 566 µM -0.47754174358531 0.329969648632539 no 2262 0.316488201594924 762 3450959 SGTC_2416 tofa 880 nM -0.47889461621981 0.329458901628309 no 2263 0.31600680060471 752 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2065 5221596 34.26 µM -0.479886966620562 0.329084463892521 no 2264 0.315653884649549 752 788581 SGTC_2507 purpurin 79.67 µM -0.480182236109289 0.328973084667003 no 2265 0.315548908485514 742 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2365 9042475 200 µM -0.481028653284069 0.328653890036898 no 2266 0.315248067150502 739 6464479 SGTC_224 benfluorex 43.875 µM -0.482588889537522 0.328065832833288 no 2267 0.31469383476007 767 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3208 9114115 49.47 µM -0.482932934589645 0.32793621860026 no 2268 0.314571678013481 774 650895 SGTC_2264 7948757 110.76 µM -0.483502810124754 0.327721571437427 no 2269 0.314369382477446 759 2971411 SGTC_840 0245-0196 390 µM -0.483841424682012 0.327594057110576 no 2270 0.314249206810227 735 3827528 SGTC_627 1391-0720 175 µM -0.484018693013424 0.327527310018043 no 2271 0.314186301417425 766 997839 SGTC_556 4058-0063 51.5 µM -0.484063544808069 0.327510422782835 no 2272 0.314170386177016 755 6615692 SGTC_2453 5731132 22.18 µM -0.487686736482698 0.3261474162512 no 2273 0.312885873973323 786 1362040 SGTC_2166 5933061 31.504 µM -0.48834666760118 0.325899406264667 no 2274 0.312652155621466 736 2877375 SGTC_1942 st076330 65.2 µM -0.488397222588258 0.325880410271955 no 2275 0.312634254390398 787 24208414 SGTC_771 0250-0039 27.3 µM -0.488612804008934 0.325799410813027 no 2276 0.312557923206827 757 3005115 SGTC_346 4513-0042 7.16 µM -0.489685359515482 0.325396546525908 no 2277 0.312178281693277 739 2827372 SGTC_2956 9076196 2.52 µM -0.490121403293856 0.325232821705824 no 2278 0.3120239967079 784 16423868 SGTC_2055 5235184 200 µM -0.490208274305922 0.325200207585595 no 2279 0.311993263152099 804 2836034 SGTC_1107 amlodipine 47 µM -0.49176489564974 0.324616029958604 no 2280 0.311442777758352 748 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2540 epiandrosterone 100 µM -0.492259242748277 0.324430598740127 no 2281 0.311268044352012 747 441302 A steroid. SGTC_895 0964-0006 13.7 µM -0.493330453918098 0.324028933305117 no 2282 0.310889556767305 759 6738897 SGTC_2471 5466956 24.79 µM -0.495159270318457 0.323343666725789 no 2283 0.310243849257249 760 724419 SGTC_1120 ficusin 1.78878 µM -0.495573908834066 0.323188382815388 no 2284 0.310097532399847 773 6199 A DNA cross-linker. SGTC_89 0302-0250 142.109 µM -0.496549754992551 0.3228230458197 no 2285 0.309753296314765 766 4203518 YLR208W SEC13 SGTC_1893 st059353 36.1 µM -0.497288493228673 0.322546590867521 no 2286 0.309492812484778 811 3112488 SGTC_288 1315-0019 35.1 µM -0.498928383164878 0.321933252338057 no 2287 0.308914918877694 758 6811474 SGTC_3046 9092212 49.47 µM -0.502022865959223 0.320777200039634 no 2288 0.307825718286652 746 25236637 SGTC_2912 7964298 10.93 µM -0.502070880088962 0.320759276329555 no 2289 0.307808831503186 758 2975850 SGTC_2339 9000433 200 µM -0.502323088651781 0.320665133549373 no 2290 0.307720135313178 732 2988954 SGTC_2242 6630449 61.2675 µM -0.50305934538578 0.320390374398733 no 2291 0.307461274348576 748 691249 YDR170C SEC7 SGTC_3161 9100388 49.47 µM -0.503131899408871 0.320363303731304 no 2292 0.307435770221263 776 25236368 SGTC_1468 k284-1086 134 µM -0.505162300368331 0.319606127923285 no 2293 0.306722423377499 752 15996457 SGTC_2792 7535235 81.82 µM -0.505203282104652 0.319590852766171 no 2294 0.306708032663284 729 1281891 SGTC_2225 6654152 15.4 µM -0.506266742272999 0.319194575444881 no 2295 0.306334703442045 774 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_855 0428-0020 25 µM -0.507086750141294 0.318889156757278 no 2296 0.306046975692464 741 6812414 SGTC_104 0074-0074 590.992 µM -0.507652979469035 0.31867833172185 no 2297 0.305848364613405 744 3943124 SGTC_3294 9122953 26.2835 µM -0.507893895868979 0.318588648738618 no 2298 0.305763877880237 765 16459826 SGTC_1495 4469-0029 237 µM -0.508715355212928 0.318282934093432 no 2299 0.305475878854865 768 793680 SGTC_2593 nobiletin 86.24 µM -0.509360274000837 0.318043007537834 no 2300 0.305249858264201 743 72344 An anti-infammatory. SGTC_1475 4092-1048 11.7 µM -0.509440913909413 0.31801301276316 no 2301 0.305221602127719 773 2881759 SGTC_2606 farnesol 9.78 µM -0.510906300224649 0.317468156605502 no 2302 0.304708334690712 779 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_469 w7 172 µM -0.511712397936692 0.317168603854078 no 2303 0.304426153950731 756 45115570 A P450 inhibitor. SGTC_340 k038-0059 454 µM -0.513160563617184 0.316630754103215 no 2304 0.303919504768627 753 23733424 SGTC_809 3998-0021 90 µM -0.513815824696042 0.316387516930155 no 2305 0.303690381502046 786 715485 SGTC_2783 7738165 71.43 µM -0.513957186574141 0.316335052891977 no 2306 0.303640962010617 746 17201110 SGTC_3196 9111891 49.47 µM -0.514334867498601 0.316194901223797 no 2307 0.30350894403162 782 18891510 SGTC_1760 st045453 10.4495 µM -0.515087975469635 0.31591551309991 no 2308 0.303245772473682 777 3323419 YIL048W NEO1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.51590717312427 0.315611726375934 no 2309 0.302959621954564 759 676296 Flavone; oxidizing agent. SGTC_905 2-aminofluorene 215 µM -0.515971052733085 0.315588042847744 no 2310 0.302937313514566 759 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1826 st055655 41.6 µM -0.518272329571277 0.314735344329884 no 2311 0.302134137988183 757 676168 SGTC_2644 guaiazulene 100 µM -0.519534220016786 0.314268191185509 no 2312 0.301694128036933 758 3515 A coloring agent. SGTC_2623 humulene 100 µM -0.520337619166589 0.313970926851947 no 2313 0.30141414012499 774 6187145 An anti-inflammatory. SGTC_586 0957-0265 8.15 µM -0.52064311353486 0.313857923065976 no 2314 0.301307704781521 763 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_605 1315-0399 119 µM -0.522310919913931 0.313241301769352 no 2315 0.300726933660558 760 24020461 SGTC_62 0180-0423 3.232 µM -0.523028889606772 0.312976014605133 no 2316 0.30047707462673 793 30102 YGL099W LSG1 SGTC_566 0958-0068 16.5 µM -0.523115388002617 0.312944060296841 no 2317 0.300446978842474 784 6815365 SGTC_3325 9138760 55.175 µM -0.523188282273138 0.312917132726736 no 2318 0.300421617461382 753 43844959 SGTC_574 1315-0397 40 µM -0.525690310676196 0.311993474649175 no 2319 0.299551698523067 766 6794277 SGTC_1477 0139-0234 16 µM -0.525864940246003 0.311929051772039 no 2320 0.299491025000786 770 620880 SGTC_2 0422-0095 29 µM -0.52620532143093 0.311803497735056 no 2321 0.299372778538981 740 6790840 SGTC_181 1447-1644 8.07 µM -0.527508146216322 0.311323135977982 no 2322 0.29892038045697 781 534600 SGTC_2343 7990716 14.84 µM -0.527989251647324 0.311145829751368 no 2323 0.298753398034437 783 6456862 SGTC_3349 9149703 23.001 µM -0.528248819197746 0.311050187119764 no 2324 0.298663324752241 775 4910494 SGTC_858 0438-0351 2.77 µM -0.528445247798768 0.310977817723367 no 2325 0.298595169707231 769 2799119 SGTC_1218 1348-1416 30.7 µM -0.529821851737351 0.310470846326174 no 2326 0.298117726562477 764 6787668 SGTC_311 1315-0136 58 µM -0.530328730402583 0.310284265218539 no 2327 0.297942015104235 773 6759207 SGTC_3355 9151058 44.0485 µM -0.53087963241331 0.310081534560441 no 2328 0.297751096341149 764 17015728 SGTC_1276 0871-0068 94.2 µM -0.532264623524749 0.309572116109245 no 2329 0.297271365141311 771 3414906 SGTC_1808 st050063 61.5 µM -0.532426942252458 0.30951243700563 no 2330 0.29721516454839 802 4011993 SGTC_850 0388-0143 75.9 µM -0.534127936227307 0.308887341435028 no 2331 0.296626511465231 779 67273 SGTC_1770 st043884 66.3 µM -0.534706542582834 0.308674836293149 no 2332 0.296426398318398 797 670149 SGTC_828 2074-0507 139 µM -0.534883187977189 0.308609972381038 no 2333 0.296365317187622 772 X828 SGTC_3035 9091303 49.47 µM -0.535511508265566 0.30837930256319 no 2334 0.296148100936963 779 25237002 SGTC_3279 9140807 49.47 µM -0.536772669299453 0.307916531687737 no 2335 0.295712326274286 782 45595718 SGTC_611 3453-1652 23.7 µM -0.537067161702189 0.307808514485897 no 2336 0.295610611438333 788 1560575 SGTC_989 1501-0895 10.3 µM -0.539322635686415 0.306981779402233 no 2337 0.294832126328659 788 2830112 SGTC_3027 9089541 49.47 µM -0.542493971435346 0.305820997780724 no 2338 0.293739129677867 774 9943819 SGTC_2511 berberine 10.47 µM -0.543175037273911 0.305571965769034 no 2339 0.293504646046231 797 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.543604568471782 0.305414953733235 no 2340 0.293356807673794 756 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1396 3511-0007 98.6 µM -0.54396045862355 0.30528488775945 no 2341 0.293234341620839 770 X1396 SGTC_465 cgp-37157 41 µM -0.544491591467107 0.305090822149945 no 2342 0.293051616556679 746 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1125 tnp00248 1.32998 µM -0.545699715176281 0.304649601374725 no 2343 0.29263618388066 760 24207736 SGTC_1307 1187-1599 12.2 µM -0.546038510369523 0.304525920411763 no 2344 0.292519732867768 780 1538471 SGTC_396 dithiazanine 1.25 µM -0.54664712419627 0.304303795282776 no 2345 0.292310593643479 765 10578 An antihelmenthic. SGTC_534 k292-0788 63.4 µM -0.546662365502413 0.304298233605906 no 2346 0.292305357134697 793 4146317 SGTC_213 1246-0773 967 nM -0.547224740057514 0.304093050203928 no 2347 0.292112170656896 776 6251622 SGTC_1572 epiandrosterone 68.9 µM -0.548892463455754 0.303484941094771 no 2348 0.291539625269826 781 441302 A steroid. SGTC_883 0850-0245 24.6 µM -0.549592348529157 0.303229900921253 no 2349 0.291299504024897 784 6823229 YPR165W RHO1 SGTC_499 genistein 192 µM -0.551598957092764 0.302499218681551 no 2350 0.290611575559619 791 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_880 0833-0487 87.2 µM -0.551612047568444 0.302494454535598 no 2351 0.290607090229624 772 76075 SGTC_2364 9055074 200 µM -0.552215689887809 0.302274801582917 no 2352 0.290400292982032 801 6470630 SGTC_2864 9034755 47.6 µM -0.552608339756864 0.302131962845193 no 2353 0.2902658150325 756 4930451 SGTC_1632 st005650 90 µM -0.55455599227343 0.301423891382442 no 2354 0.289599198585447 772 2759605 SGTC_2302 7771753 200 µM -0.55491653463063 0.301292897739523 no 2355 0.28947587585455 765 2203047 SGTC_1767 st044992 70.3 µM -0.555000338956833 0.301262453300089 no 2356 0.289447214299921 795 9600693 SGTC_3220 9131269 49.47 µM -0.555362273211804 0.301130985723405 no 2357 0.289323446045513 791 17722206 SGTC_1376 2910-0861 41.3 µM -0.556515695400936 0.300712193748177 no 2358 0.288929183924295 798 1112859 SGTC_348 k064-0012 10.7 µM -0.556692549796031 0.300648003559932 no 2359 0.288868754015645 776 5066323 SGTC_2528 xanthyletin 44.79 µM -0.55724551268353 0.300447342824771 no 2360 0.288679848854699 789 65188 An natural product with antifungal activity of unknown mechanism. SGTC_96 0929-0093 37.281 µM -0.557565754158025 0.300331160364597 no 2361 0.288570473426155 770 6991579 SGTC_720 r052-1644 49.9 µM -0.558038525734767 0.300159677652728 no 2362 0.288409038489235 795 1422863 YOR257W CDC31 SGTC_99 0109-0120 622.8 µM -0.559767206434904 0.299533031506167 no 2363 0.287819117288558 789 759414 SGTC_1429 4049-0205 9.46 µM -0.560001274582252 0.299448227483982 no 2364 0.287739284158273 771 22774478 SGTC_1072 oxiconazole 14.9 nM -0.560617957871951 0.299224852282067 no 2365 0.287529003394479 766 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_349 k015-0014 24 µM -0.561055904497488 0.299066265054543 no 2366 0.28737971358109 762 2196908 SGTC_308 4092-1169 104 µM -0.563410653460127 0.298214229113102 no 2367 0.286577642220693 787 2268590 YDL196W YDL196W SGTC_3254 9136651 49.47 µM -0.564809557820237 0.297708577411803 no 2368 0.286101652663723 813 16454030 SGTC_265 mycophenolic acid 32.932 µM -0.56584339055505 0.297335137036201 no 2369 0.28575012349123 796 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2244 6635614 200 µM -0.566391297747219 0.297137309169233 no 2370 0.285563904575137 792 836499 SGTC_113 0099-0221 2.5 µM -0.566425335940157 0.297125021294037 no 2371 0.285552337814854 792 89219 SGTC_35 0133-0054 64.071 µM -0.566477008275003 0.297106367892333 no 2372 0.285534779097701 790 99677 SGTC_3290 9121031 71.43 µM -0.566596544716558 0.297063218009055 no 2373 0.285494161525656 768 17014854 SGTC_1027 k015-0025 8.67 µM -0.567937641089054 0.296579309888094 no 2374 0.285038655846097 773 3598955 SGTC_786 4544-0069 423 µM -0.568648619859619 0.296322913805935 no 2375 0.284797311319815 762 748821 YLR208W SEC13 SGTC_898 1000-0849 28.3 µM -0.570699346701237 0.295583942262599 no 2376 0.284101730859975 804 6751807 SGTC_658 3253-0951 102 µM -0.571902138543464 0.295150915405545 no 2377 0.283694137575393 783 1184878 SGTC_3258 9138477 49.47 µM -0.572547526953255 0.294918684365126 no 2378 0.283475548598884 792 4970355 SGTC_1144 3486-0183 12.5 µM -0.573751614648685 0.294485641008018 no 2379 0.283067947633042 824 6744069 SGTC_2982 9019404 25.97 µM -0.574917778600582 0.294066516682196 no 2380 0.282673452728278 756 22333232 SGTC_3219 9131112 49.47 µM -0.575101533574248 0.294000499510713 no 2381 0.282611315417957 786 17612988 YMR079W SEC14 SGTC_1952 st077036 64.1 µM -0.575794054901437 0.293751760768743 no 2382 0.282377196213488 791 2937007 SGTC_3346 9158254 43.5805 µM -0.576580850979625 0.293469278793887 no 2383 0.28211131901002 805 17639500 SGTC_675 1309-0189 238 µM -0.576883906569495 0.29336050686903 no 2384 0.282008941444746 771 4246530 SGTC_285 1486-1325 46 µM -0.578147723000258 0.292907102680436 no 2385 0.281582194799869 776 22310230 SGTC_1253 0550-0034 176 µM -0.578368530719474 0.29282791954369 no 2386 0.281507667722884 776 5969915 SGTC_123 0083-0120 66.675 µM -0.578724414229937 0.292700318237533 no 2387 0.281387569862651 791 16001701 SGTC_2722 naftopidil 47.16 µM -0.57992067299495 0.292271591513109 no 2388 0.280984056988973 803 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1516 st013856 110 µM -0.581701028429171 0.291634072019442 no 2389 0.280384039344269 785 5281404 A mutagen and neurotoxin. SGTC_823 0417-1665 178 µM -0.581988990989242 0.291531017735057 no 2390 0.280287048156291 810 3429856 SGTC_1604 st002052 72.4 µM -0.582240823682308 0.291440907309619 no 2391 0.280202239507082 761 6254834 YHR062C RPP1 SGTC_1680 diphenhydramine 100 µM -0.582552640711403 0.291329351379502 no 2392 0.280097247412476 790 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3311 9131146 2.8755 µM -0.583414124162412 0.291021249941098 no 2393 0.279807275959373 784 4900406 YPR165W RHO1 SGTC_2165 5727197 32.143 µM -0.584108357069576 0.290773074900916 no 2394 0.279573706298565 789 1361712 SGTC_1411 3909-8223 150 µM -0.585534369390475 0.290263613294518 no 2395 0.279094231833948 799 X1411 SGTC_1465 k213-0056 144 µM -0.585846194233734 0.290152265513523 no 2396 0.278989438879468 796 24048857 YMR208W ERG12 SGTC_2232 chlorophetanol 41.5365 µM -0.586126331380507 0.290052249984695 no 2397 0.278895311326614 796 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2023 5144124 124 µM -0.586550291528825 0.289900917014916 no 2398 0.278752887883343 789 2830192 SGTC_2936 9038235 15.59 µM -0.58785988843775 0.289433689189298 no 2399 0.278313170954272 785 4749415 SGTC_1438 4092-1045 4 µM -0.588132079718189 0.289336623314044 no 2400 0.278221821082221 801 1351342 SGTC_3115 9123671 49.47 µM -0.588982136154712 0.289033584013454 no 2401 0.277936628563742 805 3286988 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.589566685937021 0.288825282687901 no 2402 0.277740595911232 802 279621 SGTC_1603 st002045 67.8 µM -0.590894915371884 0.288352237809652 no 2403 0.277295416531171 796 5887985 SGTC_2853 9015042 58.44 µM -0.591094807834657 0.288281078352326 no 2404 0.277228449291592 784 6457456 SGTC_3101 9120531 49.47 µM -0.592570054732761 0.287756163404256 no 2405 0.276734462273425 826 24824904 SGTC_752 1896-0090 130 µM -0.595378149738511 0.286758250847306 no 2406 0.275795363902001 799 772567 SGTC_2177 5811945 192 µM -0.595429220584861 0.286740117003109 no 2407 0.275778299022769 794 5343475 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.597780509498487 0.285905828650561 no 2408 0.274993198655031 805 4620898 SGTC_508 roscovitine 141 µM -0.598114423569112 0.285787442333485 no 2409 0.274881793392788 805 160355 A CDKinase inhibitor. SGTC_1354 1498-1681 81 µM -0.598424826380896 0.285677412641994 no 2410 0.274778252250993 792 5754243 SGTC_1513 0337-0559 19 µM -0.598605419506021 0.285613406370443 no 2411 0.274718020606929 792 775073 SGTC_1711 st032263 62.8 µM -0.598907691793428 0.285506289536139 no 2412 0.274617220946892 801 3958979 SGTC_1619 st003326 88.7 µM -0.598997188638443 0.285474578030253 no 2413 0.274587379662197 768 2849032 SGTC_1963 st076565 50.3 µM -0.599160295785225 0.285416788426567 no 2414 0.27453299831985 814 4914280 SGTC_2233 sulbentine 40.3845 µM -0.599418664837332 0.285325258499675 no 2415 0.274446866705849 798 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1645 Cervolide 78 µM -0.601021042718586 0.284757911930748 no 2416 0.273912985452266 789 23173 A fragrance. SGTC_2975 9084847 53.72 µM -0.60108906537161 0.284733839380415 no 2417 0.273890332987627 764 27211724 SGTC_1481 3346-2004 36 µM -0.60293874938395 0.284079626921762 no 2418 0.273274718397152 818 2770522 SGTC_3211 9128781 49.47 µM -0.603491046792934 0.283884425018726 no 2419 0.273091034921064 785 17194361 SGTC_1781 st038725 66.3 µM -0.603692357276423 0.283813290573005 no 2420 0.2730240981536 781 4270275 YIL048W NEO1 SGTC_2058 5236698 133 µM -0.604626492912446 0.283483319033028 no 2421 0.272713599741762 773 766665 SGTC_3083 9117465 49.47 µM -0.605543399456469 0.283159612371593 no 2422 0.272408998626854 819 16420915 SGTC_1087 pterostilbene 9.05 µM -0.608093733041474 0.282260170961272 no 2423 0.271562654237274 813 5281727 Similar to reservatol, lowers cholesterol. SGTC_2253 7938677 135.83 µM -0.60924598136316 0.28185425204758 no 2424 0.271180703244395 785 2301972 SGTC_2404 5161160 200 µM -0.609944167558005 0.281608428999099 no 2425 0.270949396622327 817 2831543 SGTC_1729 st035615 45.989 µM -0.610191593281927 0.281521338166942 no 2426 0.270867448983908 805 17385451 SGTC_3146 9095609 49.47 µM -0.611211242624156 0.281162571218796 no 2427 0.27052987071418 806 17173999 SGTC_1055 3448-0672 86 µM -0.611538609440579 0.281047432982015 no 2428 0.270421533023029 792 748378 SGTC_1331 1472-0049 76.2 µM -0.612855369840769 0.280584545197382 no 2429 0.269985987813612 808 24051409 SGTC_1384 3089-0840 101 µM -0.613025738829277 0.280524681444482 no 2430 0.269929660474744 784 1069836 SGTC_1638 st008370 60.6 µM -0.613050748191945 0.280515894248687 no 2431 0.269921392382617 793 24207134 SGTC_1264 0783-0040 158 µM -0.613993437453921 0.280184771673388 no 2432 0.269609831904034 797 2855798 SGTC_831 k061-1017 217 µM -0.614609798238744 0.279968375442091 no 2433 0.269406221028418 804 1240153 SGTC_2978 9011784 42.97 µM -0.614943125536018 0.279851382346889 no 2434 0.269296140596611 785 2994934 SGTC_2931 9014674 55.67 µM -0.615811364020399 0.279546754480057 no 2435 0.269009513143687 807 2996810 SGTC_3246 9135460 32.98 µM -0.616242173618653 0.279395661543977 no 2436 0.268867348876932 808 41446951 SGTC_1727 st034309 9.9045 µM -0.618501416498781 0.278603953197966 no 2437 0.268122432180051 811 870305 SGTC_531 3788-1495 174 µM -0.619898712751976 0.278114844953375 no 2438 0.267662236653339 789 2896655 SGTC_1684 st024538 14.6195 µM -0.620015599978011 0.278073948851799 no 2439 0.267623758231268 802 6732859 SGTC_647 0140-0236 81 µM -0.62071427517338 0.27782955996627 no 2440 0.267393817613905 794 990837 SGTC_836 0330-0104 1.35 µM -0.620823337291134 0.277791420703183 no 2441 0.267357933233355 792 46494820 SGTC_2481 5478948 45.16 µM -0.623315062421012 0.2769207560229 no 2442 0.266538750778769 797 77792 SGTC_1786 berberine 21.6 µM -0.624105875431145 0.276644707806879 no 2443 0.266279027794119 814 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1793 st048256 72.231 µM -0.624922842720595 0.276359671642437 no 2444 0.266010849666733 806 672022 SGTC_1060 3448-7350 82 µM -0.624943836539946 0.276352348893478 no 2445 0.266003960027621 810 570178 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.625473104849019 0.276167768919378 no 2446 0.265830297460398 789 6857784 SGTC_173 1273-0061 2.693 µM -0.626012600646663 0.275979684451639 no 2447 0.265653338225303 809 2847414 YPL266W DIM1 SGTC_1090 efavirenz 20.7 µM -0.629859621660978 0.274640323804691 no 2448 0.26439321653019 797 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_924 2046-0044 21.3 µM -0.630325405340587 0.274478376602566 no 2449 0.264240852210501 801 3623589 SGTC_459 nigericin 15.3 µM -0.63119461315258 0.274176289916189 no 2450 0.263956641872978 833 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_347 4534-1311 26.2 µM -0.63321919701498 0.273473298260613 no 2451 0.263295255605698 818 2862016 SGTC_773 4358-1457 44.6 µM -0.6348129753162 0.272920522640166 no 2452 0.262775199879749 843 1186886 SGTC_2721 ifenprodil 61.44 µM -0.640539096862273 0.270939095113788 no 2453 0.260911089882095 815 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_54 0159-0055 9 µM -0.6427482555308 0.270176576490221 no 2454 0.260193731843371 838 3319099 SGTC_2673 kobusone 100 µM -0.642888942441194 0.27012805302794 no 2455 0.26014808244086 831 6710676 An epoxy ketone and protein crosslinker. SGTC_283 0987-0079 11.7 µM -0.643485300264303 0.269922415312216 no 2456 0.259954625011913 797 411556 SGTC_1056 3448-1962 115 µM -0.644549928503633 0.269555502232853 no 2457 0.259609446040069 807 715507 SGTC_201 4262-0159 12.803 µM -0.646104063591627 0.269020334792488 no 2458 0.259105981945209 817 1341029 SGTC_484 loperamide 105 µM -0.64628900208327 0.268956686625718 no 2459 0.259046104506875 792 3955 An opioid-receptor agonist. SGTC_3036 9090181 49.47 µM -0.646680961440038 0.268821815448794 no 2460 0.258919223689504 826 25236586 SGTC_2565 isoliquiritigenin 100 µM -0.646865194022559 0.268758433711945 no 2461 0.258859597031635 795 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_629 3448-6466 76.7 µM -0.647077837595211 0.268685287044718 no 2462 0.25879078402405 824 573744 SGTC_860 0443-0016 25.1 µM -0.648173276076762 0.268308628787854 no 2463 0.258436442215306 819 5337942 SGTC_543 3844-1095 191 µM -0.648590009974989 0.268165407754683 no 2464 0.258301707204108 831 4230703 SGTC_2287 7945887 168.79 µM -0.648629828999982 0.268151724964186 no 2465 0.258288835146747 806 1245853 SGTC_864 0469-0573 172 µM -0.649195042529013 0.267957541674543 no 2466 0.258106157816895 823 689425 SGTC_1575 cyproterone acetate 48 µM -0.649749085488111 0.267767264865843 no 2467 0.257927155865813 826 9880 An androgen receptor antagonist and liver toxin. SGTC_796 1234-0020 70.7 µM -0.65015059788126 0.267629414692219 no 2468 0.257797474233499 804 46495034 SGTC_1470 k295-0292 231 µM -0.653229755285628 0.266573446310408 no 2469 0.256804085098999 829 5045612 SGTC_76 0433-0009 400.328 µM -0.653649592206968 0.266429630536662 no 2470 0.25666879300338 842 2841569 SGTC_2016 5121758 140 µM -0.654019723340231 0.266302874120604 no 2471 0.256549549346002 826 2795203 SGTC_1155 4088-0394 48.2 µM -0.655429648456662 0.265820305910054 no 2472 0.256095583899845 826 2326248 SGTC_229 benomyl 22.8748 µM -0.663091519971143 0.263205686127549 no 2473 0.253635970699667 813 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1753 st043925 64 µM -0.663618181287793 0.263026446277089 no 2474 0.253467358852594 822 670181 SGTC_3210 9128157 49.47 µM -0.665084961037372 0.262527582796741 no 2475 0.2529980765359 828 17590849 SGTC_1810 st050138 53 µM -0.665808285226225 0.262281752897603 no 2476 0.252766824225751 852 3444541 SGTC_2677 mitomycin C 100 µM -0.66631760470906 0.262108725687519 no 2477 0.252604057666127 839 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_397 arbidol 50 µM -0.668236959068678 0.261457204135525 no 2478 0.25199117345231 820 131410 A RNA synthesis inhibitor. SGTC_3108 9121785 49.47 µM -0.669458768876581 0.261042896479153 no 2479 0.251601436828489 811 17140271 SGTC_1892 st058411 7.36 µM -0.67088722917546 0.260558943336919 no 2480 0.251146186279388 832 3934738 SGTC_125 0133-0007 11.75 µM -0.672572353264117 0.25998862861134 no 2481 0.25060969761724 828 26541 SGTC_2734 clemastine 41.6 µM -0.672865425433008 0.259889506792123 no 2482 0.250516454988998 857 26987 Clemastine is a selective histamine H1 antagonist. SGTC_273 hydroxyurea 18.1 mM -0.673079804493522 0.259817012621534 no 2483 0.250448260677352 847 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1243 0416-0003 5.65 µM -0.674308510324855 0.259401716266263 no 2484 0.2500575973052 836 2141977 SGTC_792 4534-1957 155 µM -0.674766676956207 0.259246946084416 no 2485 0.249912007382481 823 1717904 SGTC_2071 5230951 39.92 µM -0.674833189873746 0.259224481771694 no 2486 0.249890875558091 840 1799272 SGTC_1294 1000-1494 117 µM -0.675253270900224 0.259082625337203 no 2487 0.249757433495681 820 712797 YDL207W GLE1 SGTC_2962 9082311 13.18 µM -0.675259498108186 0.259080522784088 no 2488 0.249755455658437 839 16459453 SGTC_2054 5233173 129 µM -0.67715799101992 0.25843992767061 no 2489 0.249152859110404 774 6889 SGTC_277 nystatin 15.5 µM -0.67717784272171 0.258433233587905 no 2490 0.249146562112422 843 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2607 solasodine 47.35 µM -0.677275961339876 0.258400148869841 no 2491 0.249115439941259 840 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1966 st070145 16.1 µM -0.678602499367757 0.257953067623668 no 2492 0.248694879389637 835 3748532 SGTC_2645 abamectin 100 µM -0.680021590963339 0.257475237821564 no 2493 0.248245394957886 813 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_764 1951-2361 146 µM -0.680239167504368 0.257402017154102 no 2494 0.248176517875538 820 5438930 SGTC_2904 7225135 42.03 µM -0.681043885364389 0.257131300843598 no 2495 0.247921861079661 862 4446116 SGTC_601 0986-0029 62.9 µM -0.681160455934738 0.257092097448356 no 2496 0.247884983335614 820 24747981 SGTC_2943 9068529 45.32 µM -0.682706264280603 0.256572526722061 no 2497 0.247396235289566 851 3270634 SGTC_101 0490-5701 117.494 µM -0.683484930146092 0.256311012044287 no 2498 0.247150234761578 818 4661669 SGTC_2646 retinol 96.75 µM -0.684513767361428 0.255965690583418 no 2499 0.246825399419188 831 445354 A vitamin A analog and teratogen. SGTC_2965 9082772 38.63 µM -0.684750455210294 0.255886282449187 no 2500 0.246750702183849 772 16459634 SGTC_3028 9087778 49.47 µM -0.685074411922282 0.255777616690939 no 2501 0.246648483053513 820 17217395 SGTC_2028 5153890 36.43 µM -0.687664768916852 0.254909592768443 no 2502 0.245831955471574 835 2830968 YPR165W RHO1 SGTC_1242 0402-0103 60.1 µM -0.688239359023649 0.254717257787674 no 2503 0.245651031052979 835 432868 SGTC_1122 capsaicin 818.572 nM -0.689311143926312 0.25435869785499 no 2504 0.245313743297743 829 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2317 5986382 200 µM -0.690105392780208 0.254093156899433 no 2505 0.245063956052766 861 877883 SGTC_1502 4534-4282 27.7 µM -0.691474507029281 0.253635762988386 no 2506 0.244633697925426 845 3278949 SGTC_212 3807-4682 38.772 µM -0.692243682132487 0.25337898669761 no 2507 0.244392155387846 829 3125501 YBL034C STU1 SGTC_2149 5554786 194.827 µM -0.694668201810503 0.252570496209159 no 2508 0.243631630010257 842 745063 YPR165W RHO1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.694789082318876 0.25253022248747 no 2509 0.243593745586423 823 6708561 SGTC_1113 artemisinin 1.17947 µM -0.695164657569691 0.252405113787943 no 2510 0.243476059135576 837 2240 An anti-malaria and mitochondrial poison. SGTC_2090 5301565 104.445 µM -0.696838790726861 0.251847837204524 no 2511 0.242951843562474 835 2056344 SGTC_2399 5884133 200 µM -0.697371704881421 0.251670579944313 no 2512 0.242785102189397 830 722445 SGTC_1281 0884-0031 11.8 µM -0.699058006507848 0.251110118761559 no 2513 0.242257890351675 848 1548255 SGTC_2100 5377183 190 µM -0.69945430054754 0.250978501889392 no 2514 0.242134081564129 822 2844202 SGTC_2897 9048598 12.99 µM -0.700254255885979 0.25071293259795 no 2515 0.241884266888125 837 6467404 SGTC_3006 9075424 71.4286 µM -0.700577859316699 0.250605544974701 no 2516 0.241783249877514 832 7465181 SGTC_2477 5967686 25.23 µM -0.70064140338296 0.250584460773197 no 2517 0.241763416462127 833 776118 SGTC_1868 st057644 42.7 µM -0.701055983678108 0.250446924271891 no 2518 0.241634039065431 836 688665 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.701221259033886 0.250392105532239 no 2519 0.241582472335854 847 23665772 A membrane-active detergent. SGTC_1278 0874-0585 172 µM -0.701438205224914 0.250320158198973 no 2520 0.241514793120322 838 766306 SGTC_643 k048-0106 28.4 µM -0.701675690073952 0.250241412058974 no 2521 0.241440718407387 842 6763920 SGTC_1467 k284-1082 293 µM -0.701968173072679 0.250144447475286 no 2522 0.241349505994491 846 3334705 SGTC_2245 6637752 200 µM -0.704180038180557 0.249411810951612 no 2523 0.240660330364952 844 681890 SGTC_2333 9017922 200 µM -0.704778374003677 0.249213820224392 no 2524 0.240474084406614 844 3163164 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.705405092129722 0.249006527384486 no 2525 0.240279087993841 843 5024745 SGTC_1987 st072290 61.9 µM -0.705889190052586 0.248846470327645 no 2526 0.240128525276448 841 54697379 SGTC_774 k060-0086 136 µM -0.706644137796483 0.248596971672724 no 2527 0.239893826312594 836 5911235 SGTC_988 1497-1057 103 µM -0.706814958849802 0.248540536426444 no 2528 0.239840738643772 842 3533044 SGTC_2349 9023730 187.07 µM -0.707314367597723 0.248375582714615 no 2529 0.23968556944335 844 4126287 SGTC_1193 1488-0126 41.5 µM -0.708609461900423 0.247948087680872 no 2530 0.239283431493868 833 1384710 SGTC_2111 5486399 200 µM -0.709842609363849 0.247541405778506 no 2531 0.23890087140203 822 689674 SGTC_163 TUB2.036 7.546 µM -0.710083557530768 0.247461984692116 no 2532 0.238826160986715 846 15992207 YJR013W GPI14 SGTC_1927 st060202 13.8 µM -0.710109764609242 0.247453347163065 no 2533 0.238818035770184 833 688887 SGTC_2192 5915882 198.485 µM -0.713370722143919 0.246379834269599 no 2534 0.237808192606118 831 2876149 SGTC_1463 k081-0032 34.1 µM -0.71346566755684 0.246348615513975 no 2535 0.237778825334856 822 977755 SGTC_1765 st044815 90.4 µM -0.718567661756046 0.244674164609216 no 2536 0.236203672211122 852 645695 SGTC_55 0767-0285 6.563 µM -0.718905523961635 0.244563496563466 no 2537 0.236099566331335 855 3116166 SGTC_1292 0kpi-0043 232 µM -0.719437681836572 0.244389240926598 no 2538 0.235935643173766 838 3333905 SGTC_313 3474-0040 5.03 µM -0.720236586221119 0.24412776454484 no 2539 0.235689670616491 842 1043375 YIL048W NEO1 SGTC_3348 9149464 3.537 µM -0.721109780577939 0.243842146171084 no 2540 0.235420986958521 833 1951442 SGTC_526 4469-0568 170 µM -0.721607287861569 0.243679494215266 no 2541 0.235267978593788 841 2901964 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.723299756154727 0.243126607968655 no 2542 0.234747871294598 849 616764 SGTC_228 caffeine 993.056 µM -0.723742271340454 0.242982161481578 no 2543 0.23461198820019 815 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2154 5570129 200 µM -0.724106992643487 0.242863143500627 no 2544 0.234500025975332 872 673366 SGTC_1417 3966-0327 90.4 µM -0.725066885399993 0.242550056524484 no 2545 0.234205499205356 857 651118 SGTC_741 4582-0002 126 µM -0.725253259459862 0.242489292489721 no 2546 0.234148337246078 848 2912688 SGTC_1161 k007-0610 110 µM -0.725713179227272 0.242339378900642 no 2547 0.234007310358049 848 5843850 SGTC_2049 5262831 67.185 µM -0.726822251152945 0.241978076964495 no 2548 0.233667425167036 853 763417 SGTC_3008 9078912 71.4286 µM -0.72862281583683 0.241392130442846 no 2549 0.233116209044957 852 16648731 SGTC_2301 7769476 200 µM -0.728879039569342 0.241308811846552 no 2550 0.233037828673956 847 977820 SGTC_2816 7982706 58.44 µM -0.729205873103267 0.241202555103775 no 2551 0.232937869585798 855 2981853 SGTC_944 3370-0224 231 µM -0.729669034151718 0.241052020532866 no 2552 0.2327962567545 841 4580514 SGTC_2063 5246145 200 µM -0.730713461460395 0.240712752915581 no 2553 0.232477095715265 847 711240 SGTC_2512 diallyl trisulfide 49.23 µM -0.730719306885728 0.240710854842427 no 2554 0.232475310127554 879 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_70 0141-0289 43.283 µM -0.732100647047168 0.240262547154013 no 2555 0.232053569460955 835 352408 SGTC_2251 lansoprazole 556 µM -0.733920193355726 0.239672716654212 no 2556 0.231498689539339 848 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_305 1682-2595 20.8 µM -0.735733422818269 0.239085720862204 no 2557 0.230946472612387 850 226033 SGTC_1379 2144-0755 36.5 µM -0.737203344138372 0.238610441353425 no 2558 0.230499350052481 864 5392327 SGTC_68 0986-0284 82.829 µM -0.737832401740918 0.238407202049424 no 2559 0.230308150438191 833 423278 YIL048W NEO1 SGTC_106 0092-0003 11.579 µM -0.739741306375316 0.237791043583297 no 2560 0.229728489550208 842 1072148 SGTC_525 k781-2675 26.7 µM -0.740446214000145 0.237563733687977 no 2561 0.229514642971473 836 3651118 YDL195W SEC31 SGTC_3113 9123498 49.47 µM -0.74086052498247 0.237430187467458 no 2562 0.229389006245746 868 8897275 SGTC_2784 7567673 72.73 µM -0.741171751188113 0.237329896016506 no 2563 0.229294654572733 850 3471247 SGTC_361 000s-0510 1.45 µM -0.741226448162258 0.237312272530224 no 2564 0.229278074827151 857 660 SGTC_954 1189-0853 2.85 µM -0.742241927210815 0.23698521349295 no 2565 0.228970384946714 849 2828194 SGTC_2359 9039622 200 µM -0.742449314335574 0.236918450043897 no 2566 0.228907575205881 865 6463596 SGTC_846 0335-0850 148 µM -0.742561080055317 0.236882473964666 no 2567 0.228873729593379 841 6819598 SGTC_430 0958-0115 16.4 µM -0.743299308078849 0.236644922442789 no 2568 0.228650245202567 863 6833180 SGTC_1324 1418-0026 34.4 µM -0.744763771287057 0.236174066623276 no 2569 0.228207269906055 853 1372513 SGTC_2836 9010338 19.48 µM -0.745034956856394 0.236086931402464 no 2570 0.22812529384401 853 2994051 SGTC_2395 5646831 180.19 µM -0.745466252444478 0.235948387377053 no 2571 0.22799495260775 852 6808628 SGTC_2367 9070478 135.38 µM -0.747894069199276 0.235169342394469 no 2572 0.227262027587891 841 572802 SGTC_1831 st055328 12 µM -0.748462310580563 0.234987208791913 no 2573 0.227090675153652 855 1103068 SGTC_2259 7964009 200 µM -0.750542856536874 0.234321014535703 no 2574 0.226463911235521 841 313134 SGTC_3151 9099821 49.47 µM -0.750780190031266 0.23424508643735 no 2575 0.226392476702666 852 17174189 SGTC_115 0527-0192 112.043 µM -0.751268278580996 0.234088979209749 no 2576 0.226245607912252 877 4233931 SGTC_2284 7945075 39.21 µM -0.752983268466916 0.233540924570897 no 2577 0.225729984186338 861 1245402 SGTC_2800 7887935 81.82 µM -0.757108498900759 0.232225555041296 no 2578 0.224492431363456 870 2961002 SGTC_1348 1493-0373 93.8 µM -0.757860168602811 0.231986322721753 no 2579 0.224267348818749 874 3010129 SGTC_1777 st045864 34.765 µM -0.758115311366265 0.231905150182264 no 2580 0.224190977134395 880 4691462 SGTC_3041 9091929 49.47 µM -0.759652018598714 0.23141658827481 no 2581 0.223731308227775 852 25236887 SGTC_2010 4012422 159 µM -0.760318905573011 0.231204745101401 no 2582 0.22353199191277 865 952393 SGTC_1077 5-fluorocytosine 377 nM -0.760537424579176 0.231135353942684 no 2583 0.223466703866275 872 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_783 0848-0141 92.7 µM -0.760601415596965 0.23111503566386 no 2584 0.223447586994736 862 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3307 9126885 69.2785 µM -0.761171145701243 0.230934180237996 no 2585 0.223277425110783 857 24824909 SGTC_3252 9135871 49.47 µM -0.764069880988503 0.230015228956835 no 2586 0.222412799918224 867 17682838 SGTC_854 0422-0053 192 µM -0.765218044829095 0.229651806937474 no 2587 0.222070858122733 871 3596728 SGTC_1539 benzyladenosine 56 µM -0.765300077755716 0.229625853820567 no 2588 0.222046438879903 847 92208 A nucleotide analog. SGTC_2754 granisetron 64.02 µM -0.770622405619867 0.227945521007928 no 2589 0.220465388340694 860 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3180 9109287 49.47 µM -0.771957444365535 0.227525118511545 no 2590 0.220069816286414 843 18891271 SGTC_3266 9136860 49.47 µM -0.7731279872944 0.227156875136052 no 2591 0.219723319590907 850 4871271 YPR165W RHO1 SGTC_43 0570-0105 72.5 µM -0.773326089269222 0.227094587106527 no 2592 0.219664709706266 856 1114046 YDL195W SEC31 SGTC_3217 9129673 49.47 µM -0.773423698308629 0.227063900016337 no 2593 0.219635834676218 862 17248312 SGTC_3316 9136639 10.545 µM -0.77361338954856 0.227004270093828 no 2594 0.219579725818333 859 4903665 SGTC_3167 9103034 49.47 µM -0.773873145268057 0.226922629551368 no 2595 0.219502905912837 854 5127859 SGTC_940 3232-1287 54.8 µM -0.774243455091461 0.226806270780944 no 2596 0.219393417540571 854 1585493 YIL048W NEO1 SGTC_3109 9122853 49.47 µM -0.774814460602795 0.226626915389752 no 2597 0.219224651603065 904 1234709 SGTC_63 0099-0242 26.702 µM -0.776095253888702 0.22622490378762 no 2598 0.218846372897104 870 3898502 YLR359W ADE13 SGTC_987 1497-1013 404 µM -0.778038380222401 0.22561577107137 no 2599 0.218273193671438 860 1676435 SGTC_1421 4029-0249 71.4 µM -0.778868833083226 0.22535572343075 no 2600 0.218028492535142 873 2894095 SGTC_131 0141-0277 33.849 µM -0.780754255940374 0.224765953463262 no 2601 0.217473521574952 877 1547771 SGTC_2157 5649910 96.377 µM -0.78169046148735 0.224473429057982 no 2602 0.217198254359199 873 2858091 SGTC_2214 7179297 48.276 µM -0.782056695695594 0.22435905526162 no 2603 0.21709062737916 853 769744 SGTC_1605 st000082 49.1 µM -0.782606450730486 0.224187430597922 no 2604 0.216929126125603 853 1114022 SGTC_2684 capsaicin 100 µM -0.784466272212564 0.223607377347651 no 2605 0.216383282474742 875 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1960 st011366 51.8 µM -0.784979084032754 0.223447588493917 no 2606 0.216232915985254 870 3972846 SGTC_824 1304-0008 100 µM -0.785171641227707 0.223387605694545 no 2607 0.21617647006422 868 768245 SGTC_1850 st056238 17 µM -0.785211873239155 0.223375074322536 no 2608 0.216164677591742 852 5393177 SGTC_3273 9137859 49.47 µM -0.788202039347282 0.222444824750165 no 2609 0.215289268223228 907 2377234 SGTC_714 4296-0578 26.1 µM -0.788319220663202 0.222408414339848 no 2610 0.21525500383742 873 1589775 SGTC_2924 9010168 62.78 µM -0.788708624609504 0.222287443724534 no 2611 0.215141162968279 876 2993929 SGTC_1776 st049249 45.9 µM -0.789561824905386 0.2220225233355 no 2612 0.214891855091088 873 1822314 SGTC_962 1254-0300 21.5 µM -0.790187410006337 0.221828392508052 no 2613 0.214709163784668 839 7340576 SGTC_3255 9139072 49.47 µM -0.790199527250196 0.22182463325671 no 2614 0.21470562604448 865 17646060 SGTC_2475 5812728 15.03 µM -0.790308509613017 0.221790824225452 no 2615 0.214673809169146 859 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_624 k048-0052 28 µM -0.790617877696217 0.221694866614521 no 2616 0.214583505579617 859 6835531 SGTC_1011 4112-3381 17.4 µM -0.790906631930319 0.221605324268765 no 2617 0.214499239035528 867 2877139 SGTC_3070 9117005 49.47 µM -0.791050856173343 0.221560608242961 no 2618 0.214457157581941 874 8779016 SGTC_2191 5911152 200 µM -0.79156546165269 0.221401099350079 no 2619 0.214307046178348 852 2875902 SGTC_1853 st056710 91.2 µM -0.791591328338567 0.221393083356292 no 2620 0.214299502430126 877 269167 SGTC_2652 actinonin 100 µM -0.794976876549833 0.220345347224664 no 2621 0.213313476570065 872 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_700 3453-2283 142 µM -0.796313920935853 0.21993235217965 no 2622 0.212924798112736 873 565664 SGTC_1464 k208-0027 110 µM -0.797193176234379 0.219661004308192 no 2623 0.212669424238726 858 X1464 SGTC_1607 st000305 50.6 µM -0.797405702751288 0.219595445144462 no 2624 0.212607724170663 875 5457690 SGTC_928 2764-0428 58.7 µM -0.799760127351343 0.218869915695617 no 2625 0.211924894330623 875 662578 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.802163870159387 0.218130613316351 no 2626 0.211229086425609 888 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_441 propafenone 146 µM -0.802325521595966 0.218080947017829 no 2627 0.211182341505854 883 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1673 st016611 27.3 µM -0.802352627332451 0.218072619603841 no 2628 0.211174503904362 888 5226799 SGTC_1721 st082152 9.2685 µM -0.80919076250258 0.215977673286345 no 2629 0.209202713766013 888 5296051 SGTC_2372 9071633 200 µM -0.810681315788942 0.215522576705011 no 2630 0.208774352934649 879 21321366 SGTC_1302 1159-0335 255 µM -0.810802326072842 0.215485654201325 no 2631 0.208739599241314 874 649284 SGTC_2526 patulin 37.61 µM -0.811027479105401 0.215416965559636 no 2632 0.208674945220803 885 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_969 1313-0238 134 µM -0.812690993460711 0.214909862085972 no 2633 0.208197623160102 882 5212874 SGTC_528 3492-0019 172 µM -0.814163055894011 0.214461699370249 no 2634 0.207775773334869 876 2869262 SGTC_1611 st001856 99.4 µM -0.814511917233185 0.214355569827102 no 2635 0.207675873979949 883 647478 SGTC_1141 3253-0389 52.6 µM -0.814651390289413 0.214313148303646 no 2636 0.207635942648364 881 5402031 SGTC_2133 5320837 200 µM -0.81471656233034 0.214293327530782 no 2637 0.2076172853569 892 2841355 SGTC_2875 9039966 71.43 µM -0.815899360664484 0.213933788398895 no 2638 0.20727884892176 886 6463691 SGTC_3066 9117245 49.47 µM -0.816735240003908 0.213679915308596 no 2639 0.20703987396536 855 17176980 SGTC_3337 9144342 33.5465 µM -0.818844901607959 0.213039950325639 no 2640 0.206437454528421 855 17682949 SGTC_3122 9126309 49.47 µM -0.819872626771116 0.212728595812241 no 2641 0.20614436148312 901 17591206 SGTC_2768 sulfasalazine 50.2 µM -0.82191435127524 0.212110833871961 no 2642 0.205562822257922 887 5384001 An antioxidant and salicylic acid derivative. SGTC_320 4092-0846 5.34 µM -0.821986874963743 0.212088909781973 no 2643 0.205542183447426 859 1359356 SGTC_2773 thioridazine 9.09 µM -0.822218528040277 0.212018889361767 no 2644 0.205476267794885 887 5452 An antipsychotic. SGTC_2377 9073351 62.6 µM -0.822610119914677 0.211900555924653 no 2645 0.20536487095439 905 7337946 YHR072W ERG7 SGTC_2138 5575593 77.673 µM -0.824734385368496 0.211259307033095 no 2646 0.204761202718162 874 762213 SGTC_203 k066-0004 30.888 µM -0.824873951223473 0.21121721633277 no 2647 0.20472157823943 895 6795412 SGTC_1401 3807-4679 7.6 µM -0.825485697137891 0.211032782095358 no 2648 0.204547949799292 878 3291456 SGTC_2468 5987765 72.9 µM -0.825752860655209 0.210952265045842 no 2649 0.204472149763536 869 26772094 SGTC_2921 7974240 10.71 µM -0.826019183839447 0.210872019182846 no 2650 0.204396604790021 862 2979074 YDR527W RBA50 SGTC_890 0929-0006 47.2 µM -0.828126459071857 0.210237707327296 no 2651 0.203799443218857 886 1378169 SGTC_3275 9138069 49.47 µM -0.828915955445854 0.210000349524431 no 2652 0.203575983089922 883 17617007 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.831689935987978 0.209167616888365 no 2653 0.202791991366956 897 688801 SGTC_2116 5511452 16.8835 µM -0.832343460078603 0.208971716134219 no 2654 0.202607553071642 885 870744 SGTC_82 0054-0107 293.755 µM -0.832549919302701 0.208909850270075 no 2655 0.202549306766956 876 3104697 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.832579178646096 0.208901083530126 no 2656 0.202541052926864 881 16725076 SGTC_3182 9108849 49.47 µM -0.832819675056352 0.208829033751822 no 2657 0.202473218321959 870 17133045 SGTC_191 3914-0123 66.505 µM -0.835406207981868 0.208055066168789 no 2658 0.201744517828759 893 3144412 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.835490122079075 0.208029984964929 no 2659 0.20172090315539 892 5282362 SGTC_2838 9002687 71.43 µM -0.835720091751115 0.20796125815145 no 2660 0.20165619475958 892 6457060 SGTC_1172 0370-0043 85 µM -0.835845529878109 0.207923776412393 no 2661 0.201620904477242 889 376585 SGTC_1487 3970-0795 2.82 µM -0.837038621384697 0.207567472248841 no 2662 0.201285429658354 873 3765103 SGTC_821 1114-0266 29.2 µM -0.838128625162543 0.207242269758436 no 2663 0.200979233869513 874 3123235 SGTC_192 3455-0609 60.9 µM -0.83848394205615 0.207136326162634 no 2664 0.200879481301293 869 3769639 SGTC_2844 9010103 25.97 µM -0.838513894115622 0.207127396926151 no 2665 0.200871073841899 883 2480525 SGTC_743 1275-0778 158 µM -0.840143030227417 0.206642065847226 no 2666 0.200414098030244 883 2849257 YMR203W TOM40 SGTC_1317 1273-0028 910 nM -0.842816430168594 0.205847102194668 no 2667 0.199665558781338 876 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_733 4069-0007 56.1 µM -0.842972319874322 0.205800802802099 no 2668 0.199621962374045 898 5717425 YNL287W SEC21 SGTC_1114 scopoletin 1.73284 µM -0.843678388383541 0.205591177161612 no 2669 0.199424573669211 891 5280460 A coumarin with genotoxic properties. SGTC_572 0960-0087 17.7 µM -0.84684356995558 0.204653020999395 no 2670 0.198541159633063 896 6796365 SGTC_1683 st010134 710 nM -0.847693072312687 0.20440166365546 no 2671 0.198304462744795 914 3818134 SGTC_2925 9010536 32.5 µM -0.847787862744538 0.204373627728962 no 2672 0.198278061847689 840 2994177 SGTC_965 1291-5240 308 µM -0.849887915882165 0.203753087670754 no 2673 0.197693702297628 907 2834598 SGTC_3285 9112818 20.8695 µM -0.850633696880543 0.203532989046852 no 2674 0.197486432413902 890 17017947 YPR165W RHO1 SGTC_2291 7917025 104.35 µM -0.850704095669267 0.20351221993112 no 2675 0.19746687374249 880 2964612 SGTC_2876 9059903 25.97 µM -0.85102240920208 0.203418326559907 no 2676 0.197378452328701 856 6916095 SGTC_1775 st081588 35.1725 µM -0.853751316232287 0.20261443822624 no 2677 0.196621397141823 885 1426443 YGL099W LSG1 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.853820442326423 0.202594099576102 no 2678 0.196602243007363 907 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1564 D-Arginine 115 µM -0.854425675298148 0.202416076807311 no 2679 0.196434587415959 898 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2710 st078562 53.7235 µM -0.855533127296701 0.202090573988574 no 2680 0.196128036542494 888 17250908 SGTC_3081 9117243 49.47 µM -0.855719395161876 0.202035856837506 no 2681 0.19607650474264 888 45595589 SGTC_2222 6885208 172.143 µM -0.855763985035285 0.202022759646447 no 2682 0.196064169982228 890 609514 SGTC_1919 st067113 52.3 µM -0.857172407608567 0.201609331326475 no 2683 0.195674804605771 907 1268243 SGTC_86 0417-1630 471.922 µM -0.857343075791956 0.201559267845733 no 2684 0.195627654451925 880 3634867 SGTC_172 1112-0046 2.638 µM -0.858991252396768 0.201076178238981 no 2685 0.195172671084104 918 2802135 YIL048W NEO1 SGTC_509 pifithrin 175 µM -0.859268112236976 0.200995097279712 no 2686 0.195096306353633 910 4817 A p53 inhibitor. SGTC_2693 st077581 40.7 µM -0.859649066130592 0.20088356348275 no 2687 0.194991259625013 870 25238761 SGTC_463 ikarugamyin 104 µM -0.860289047388328 0.200696276555327 no 2688 0.19481486441939 915 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3112 9123419 49.47 µM -0.861734461115538 0.200273670215535 no 2689 0.194416828719383 926 17015854 SGTC_1937 st074714 47.2 µM -0.862404746851877 0.200077875408505 no 2690 0.194232414659559 899 17250970 SGTC_985 1493-0307 8.71 µM -0.862526180052541 0.200042416299125 no 2691 0.194199016444686 910 3278274 SGTC_1196 1588-0294 184 µM -0.862864496904085 0.199943645992822 no 2692 0.19410598637889 900 6144269 SGTC_877 0771-0151 33.1 µM -0.864185390982462 0.199558296878725 no 2693 0.193743028096797 903 6166523 SGTC_2831 7999036 19.48 µM -0.86426736119009 0.199534398157908 no 2694 0.193720517780374 916 2988270 SGTC_3239 9133757 49.47 µM -0.864567056812338 0.199447035441022 no 2695 0.193638230192775 909 17036923 SGTC_2805 7950783 58.44 µM -0.865557917527644 0.199158358729445 no 2696 0.193366320804907 886 1178958 YDL195W SEC31 SGTC_1674 st016616 23.6 µM -0.86631891565454 0.198936821007988 no 2697 0.19315764796075 873 625830 SGTC_1824 st053723 68.6 µM -0.866370894469258 0.198921694632866 no 2698 0.193143399898061 886 675225 SGTC_342 k048-0088 23.3 µM -0.867324756743227 0.198644233897267 no 2699 0.192882047893511 894 6820570 SGTC_820 1582-0060 59.9 µM -0.868470858023635 0.198311163290744 no 2700 0.192568309523537 895 3848840 SGTC_1037 k284-1091 78.7 µM -0.868897520639274 0.198187256223171 no 2701 0.192451592905575 887 3334711 SGTC_2775 cyproheptadine 69.59 µM -0.86917803471724 0.198105817615434 no 2702 0.192374879839336 879 2913 A selective serotonin reuptake inhibitor. SGTC_312 4092-0653 6.84 µM -0.869277021235381 0.198077084757745 no 2703 0.19234781414919 878 1148278 SGTC_600 1495-0418 41.6 µM -0.869600404357488 0.197983233745334 no 2704 0.192259408366288 901 5377768 SGTC_2033 5192550 145 µM -0.870194443514263 0.197810903969498 no 2705 0.192097075990328 853 182073 SGTC_2006 4011487 200 µM -0.870666078646565 0.197674147961645 no 2706 0.191968252560374 898 45595294 SGTC_1052 3253-3998 198 µM -0.870694301982334 0.19766596609466 no 2707 0.191960545255106 899 5450317 SGTC_335 4077-0256 27.6 µM -0.870979742279443 0.197583229245345 no 2708 0.191882607086926 885 3121989 SGTC_2243 6634756 200 µM -0.871108122487883 0.197546024177956 no 2709 0.191847559774226 884 885676 SGTC_933 2914-0560 114 µM -0.872390605876481 0.197174588202229 no 2710 0.191497661804132 880 463887 SGTC_2029 5175081 200 µM -0.876665219690561 0.195939618822462 no 2711 0.190334251609756 889 1380876 SGTC_1145 3546-0597 10.2 µM -0.876966150555004 0.195852854722313 no 2712 0.190252511963928 886 875334 SGTC_1247 0448-0043 5.84 µM -0.877011282522772 0.195839844327152 no 2713 0.190240254958106 917 3089013 YGL099W LSG1 SGTC_3304 9125678 46.087 µM -0.877380736375089 0.195733359926214 no 2714 0.190139936381692 897 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2601 securinine 100 µM -0.877987657355882 0.19555850879075 no 2715 0.1899752084373 899 442872 A GABA receptor antagonist. SGTC_25 0118-0223 35.662 µM -0.87890314581037 0.19529494029625 no 2716 0.189726896429865 879 5333628 SGTC_1285 0929-0069 65.5 µM -0.879292641798195 0.195182870147865 no 2717 0.189621312257584 891 1206237 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.879369275116548 0.195160824953421 no 2718 0.189600542832714 890 688761 SGTC_1036 k216-0215 33.5 µM -0.879809421377319 0.195034236883093 no 2719 0.189481279987969 841 622330 SGTC_3264 9137442 49.47 µM -0.880661363237791 0.194789356380594 no 2720 0.18925056743582 879 17015726 SGTC_2294 7971431 200 µM -0.881037440718522 0.194681316931793 no 2721 0.18914877774613 922 5741572 SGTC_372 0155-0182 15.9 µM -0.881466367912785 0.194558139343041 no 2722 0.189032724837055 836 771486 SGTC_3022 9087993 49.47 µM -0.881893431633033 0.19443554403213 no 2723 0.188917219703872 909 17173644 SGTC_738 1315-0003 72.4 µM -0.883315991276951 0.194027515395449 no 2724 0.18853278305851 917 6251474 SGTC_1279 0874-0590 65.2 µM -0.883945033476094 0.193847255529674 no 2725 0.188362942795547 903 3523074 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.884113756241439 0.193798923289751 no 2726 0.188317404009327 890 6708514 SGTC_2529 gangaleoidin 93.61 µM -0.885908685641716 0.193285203586252 no 2727 0.187833367674465 897 4565183 SGTC_1852 st056254 31.4 µM -0.886211838674818 0.193198521451455 no 2728 0.187751692686541 877 442583 SGTC_146 3448-8650 53.125 µM -0.887096243280737 0.192945774630038 no 2729 0.1875135432354 927 2891488 YIL048W NEO1 SGTC_2091 4-phenylthiadiazole 200 µM -0.889694325618646 0.192204458504082 no 2730 0.186815020863735 906 270010 SGTC_3131 9127911 49.47 µM -0.890723483369753 0.19191128925591 no 2731 0.186538766640579 886 45595681 SGTC_1178 0988-0033 191 µM -0.891484181727865 0.191694770261739 no 2732 0.186334736986738 887 5392207 SGTC_2018 5133068 143 µM -0.891958660807193 0.191559794183613 no 2733 0.186207545280602 909 785362 SGTC_712 r015-0009 80.6 µM -0.89252276003258 0.191399399445756 no 2734 0.186056399487386 917 6813872 YLR060W FRS1 SGTC_1722 st034304 3.6505 µM -0.892632778760753 0.191368126555198 no 2735 0.186026929730803 918 4036148 YLR033W RSC58 SGTC_1947 st076332 61.6 µM -0.893528950074812 0.191113505970499 no 2736 0.185786987944163 903 24208416 SGTC_2272 7805186 180 µM -0.893599480780119 0.191093475577542 no 2737 0.185768112135931 929 2956062 YPR165W RHO1 SGTC_2823 7987624 58.44 µM -0.89424445916734 0.190910364428094 no 2738 0.185595554719983 897 2239440 SGTC_2020 4017018 200 µM -0.899281314915937 0.189484092513015 no 2739 0.184251418689669 931 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3197 9113331 49.47 µM -0.899342002669803 0.189466947811847 no 2740 0.184235260570373 892 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_907 3448-6986 75.5 µM -0.901056887918761 0.188982875809749 no 2741 0.183779036819898 916 590582 SGTC_2304 7443016 91.4 µM -0.901299743111486 0.188914385107553 no 2742 0.18371448517244 913 939854 SGTC_1864 st057645 30.4 µM -0.901347970867969 0.188900785600797 no 2743 0.183701667769719 908 688666 SGTC_3331 9141060 1.957 µM -0.902229362153707 0.188652352682462 no 2744 0.183467520160117 897 4906567 YPR165W RHO1 SGTC_2778 tioconazole 65.09 nM -0.902591883442637 0.188550229284508 no 2745 0.183371267924474 897 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2592 piperlongumine 83.33 µM -0.904832206729117 0.187919879614169 no 2746 0.182777143267838 929 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_646 4092-0839 27.3 µM -0.904931100810507 0.187892084251139 no 2747 0.182750944681428 896 877796 SGTC_1748 st037455 53.6035 µM -0.906361848176547 0.187490239696445 no 2748 0.182372179702865 898 580690 SGTC_1349 flufenamic acid 69 µM -0.910304525649574 0.186385637227029 no 2749 0.181330966245971 908 3371 A non-steroidal anti-inflammatory. SGTC_2357 9067248 200 µM -0.911620890138 0.186017736751126 no 2750 0.180984160793384 939 9150235 SGTC_2472 5377652 49.4 µM -0.912998608647954 0.185633171457616 no 2751 0.180621636651464 936 1610903 SGTC_2865 9030313 51.95 µM -0.913701148067291 0.185437260288929 no 2752 0.180436950302395 914 42562754 SGTC_310 1273-0058 1.06 µM -0.919397119802139 0.183853615545108 no 2753 0.178943947635318 859 2734232 SGTC_642 0335-0876 158 µM -0.920739713215752 0.183481566099905 no 2754 0.178593168452913 912 6812350 SGTC_2314 7727897 200 µM -0.92077416457654 0.18347202537621 no 2755 0.178584173053291 863 900724 SGTC_2465 5809242 33.21 µM -0.922684365877301 0.182943511315003 no 2756 0.178085857791121 939 2731748 SGTC_2558 carylophyllene oxide 100 µM -0.924583983163611 0.182418868840923 no 2757 0.17759117381968 922 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2332 7982454 138.89 µM -0.925375472510828 0.182200550425164 no 2758 0.177385316329361 920 2981748 SGTC_2326 6164455 177.58 µM -0.925553919607957 0.182151351500961 no 2759 0.177338925063886 918 2888790 SGTC_2762 leflunomide 42.06 µM -0.926109199178865 0.181998310757675 no 2760 0.177194616884834 926 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_479 n-linoleoylglycine 10 µM -0.926874221060899 0.181787594616246 no 2761 0.176995921592636 922 6433346 An anti-infammatory. SGTC_1265 0819-1001 68.8 µM -0.928016591498187 0.181473226550035 no 2762 0.176699481638638 914 3106768 SGTC_216 k038-0035 28.382 µM -0.931621370425168 0.180483463136857 no 2763 0.175766117466406 916 4444231 YPR107C YTH1 SGTC_21 0849-0113 22.993 µM -0.935133201670751 0.179522483326619 no 2764 0.174859828933487 896 1560156 SGTC_3334 9142812 21.919 µM -0.937756201923334 0.178806825991195 no 2765 0.174184856960902 914 45283678 SGTC_2109 5483026 200 µM -0.941204058544528 0.177868851475443 no 2766 0.173300148649679 922 759335 SGTC_2321 7390090 138.78 µM -0.941510767748817 0.177785563137225 no 2767 0.173221586921807 933 649046 SGTC_1755 st041960 45.185 µM -0.942833527222118 0.177426643450306 no 2768 0.172883029868888 919 2257073 SGTC_403 arphamenine a 50 µM -0.942891049816459 0.17741104556272 no 2769 0.172868316674996 918 5487158 An arginine aminopeptidase inhibitor. SGTC_681 1642-0006 26.6 µM -0.944461578474939 0.176985513866422 no 2770 0.172466913426432 945 4446530 SGTC_3156 9099931 49.47 µM -0.94732445639031 0.17621148356299 no 2771 0.171736736191238 928 18111053 SGTC_591 4299-0174 154 µM -0.94790518380539 0.176054735270722 no 2772 0.171588862862054 943 5509088 SGTC_1028 k015-0029 4.8 µM -0.947918215207962 0.176051218884577 no 2773 0.171585545548786 911 4588309 SGTC_7 0192-1582 4.227 µM -0.951419212190526 0.175108122832692 no 2774 0.170695805675439 946 252616 SGTC_158 k038-0087 26.446 µM -0.954404321862711 0.174306532231684 no 2775 0.169939509715452 876 X158 SGTC_2338 7999974 200 µM -0.954704385055883 0.174226085513586 no 2776 0.1698636058542 908 315925 SGTC_1681 tripelennamine 100 µM -0.956044499416307 0.173867089914166 no 2777 0.169524876463619 892 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2498 4'-Methoxychalcone 54.63 µM -0.956966018408985 0.173620502608211 no 2778 0.169292203542315 923 641818 YHR062C RPP1 SGTC_366 0181-0206 4.31 µM -0.957068702889531 0.173593039272525 no 2779 0.169266289594653 938 274874 SGTC_1108 betulinic acid 729.144 nM -0.957755937802868 0.173409306974228 no 2780 0.169092921254633 899 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2202 7226349 200 µM -0.959074815136968 0.173057051910842 no 2781 0.168760528391115 907 844334 SGTC_210 3551-0445 56.827 µM -0.959109735208036 0.173047731410321 no 2782 0.168751733295613 922 2865180 YOR207C RET1 SGTC_2695 st077686 51.995 µM -0.95916779061157 0.173032236576344 no 2783 0.168737111903472 927 2876092 SGTC_401 neomycin 50 µM -0.959396462700244 0.172971213196804 no 2784 0.168679528210612 888 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1426 4048-4480 71.7 µM -0.961190584922642 0.172492910074682 no 2785 0.168228174731864 915 14224343 SGTC_2391 6285546 200 µM -0.961413969620355 0.1724334160479 no 2786 0.168172031517836 916 846083 SGTC_845 0330-0138 4.51 µM -0.961897540226635 0.172304671570115 no 2787 0.168050537150005 914 9039800 SGTC_668 1682-0499 62.6 µM -0.962283959911215 0.172201836376137 no 2788 0.167953492012515 924 682214 SGTC_1071 trifluoperazine 6.31 µM -0.962290528136134 0.172200088758519 no 2789 0.167951842785482 945 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1146 3579-1023 7 µM -0.963935010986761 0.171762894873192 no 2790 0.167539254754089 941 X1146 SGTC_1962 st076595 64.5 µM -0.964885151067855 0.171510618869011 no 2791 0.167301169816774 912 279619 SGTC_2040 5100729 123 µM -0.967867615028261 0.170720270407427 no 2792 0.166555244968428 915 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3309 9129340 25.759 µM -0.968699957428941 0.170500117652795 no 2793 0.166347456909014 910 17158987 SGTC_1631 benzylvanillin 81.9 µM -0.969303097903492 0.170340701957323 no 2794 0.166196992042084 897 75506 SGTC_2449 5812982 45.77 µM -0.970055073028119 0.170142081634964 no 2795 0.166009520708637 935 776185 SGTC_1353 1498-1206 8.11 µM -0.970585807012841 0.170001987442034 no 2796 0.1658772882382 873 6756808 SGTC_2185 6113692 200 µM -0.972631199922093 0.169462770995257 no 2797 0.165368315173682 928 874150 SGTC_2680 butyl paraben 22.24 µM -0.973043354070881 0.16935424991117 no 2798 0.165265877688733 953 7184 An antifungal and steroid mimetic. SGTC_2247 cerulenin 830 nM -0.974296437664101 0.169024584306254 no 2799 0.164954686462842 898 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3063 1327-0034 4 µM -0.975827948009805 0.168622229322385 no 2800 0.164574866254978 908 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1774 st048371 48.465 µM -0.976246605927406 0.168512347687923 no 2801 0.164471136267977 939 4242727 SGTC_432 NS 1619 61.3 µM -0.977658043226477 0.168142238886174 no 2802 0.164121739773041 910 4552 A K+/calcium channel activator. SGTC_1943 st076331 65.2 µM -0.979935413384258 0.167546167783633 no 2803 0.1635590004219 931 24208415 SGTC_209 4077-0173 175.592 µM -0.98106558165708 0.167250867399393 no 2804 0.163280200982941 905 15993494 SGTC_3030 9087619 49.47 µM -0.981331283127557 0.167181491300268 no 2805 0.16321470035877 903 25236973 SGTC_1617 st002906 78 µM -0.982872786543783 0.166779362471345 no 2806 0.162835026459922 940 5150859 SGTC_1612 st002233 45.4 µM -0.983289868611355 0.166670666486744 no 2807 0.162732397513132 903 1035021 SGTC_2980 9014342 25.29 µM -0.983623114438026 0.166583851973497 no 2808 0.162650427903269 904 2996599 SGTC_1197 1601-0112 267 µM -0.985213491364024 0.166169941912364 no 2809 0.162259607513403 930 7350313 SGTC_1925 st057770 10.1 µM -0.98682440575055 0.165751364659207 no 2810 0.161864364017999 928 5989122 SGTC_1978 st071761 42 µM -0.987286986380268 0.165631294583039 no 2811 0.161750984260588 917 5147680 SGTC_281 1672-3440 14.9 µM -0.989991986507005 0.164930295732718 no 2812 0.161089017938964 929 6833000 SGTC_2760 etidronate 98.04 µM -0.990237583766615 0.164866744654699 no 2813 0.161029003159209 922 3305 A chelator and antioxidant. SGTC_254 nsc-64875 3.808 µM -0.992136606547236 0.16437588647297 no 2814 0.160565445747839 930 56993 SGTC_2950 9072895 21.46 µM -0.992700171988677 0.164230398934587 no 2815 0.160428045553041 896 17332245 SGTC_698 k064-0052 127 µM -0.994144196185197 0.163857997324591 no 2816 0.160076335640531 974 5088751 SGTC_1840 st055363 71 µM -0.994510093459337 0.163763722607418 no 2817 0.159987296963072 954 676033 SGTC_1448 4255-0083 152 µM -0.99457533635774 0.163746916244891 no 2818 0.159971423939074 952 5399660 SGTC_980 1473-0395 201 µM -0.994858922296178 0.163673878421389 no 2819 0.159902441939549 924 768876 SGTC_881 0833-0569 170 µM -0.994931530773834 0.163655181441424 no 2820 0.159884783127976 929 5418700 SGTC_679 0422-0091 41.4 µM -0.994999571822285 0.163637661851752 no 2821 0.159868236300016 943 627384 YHR062C RPP1 SGTC_2556 citropten 84.59 µM -0.997320667370149 0.163040742520252 no 2822 0.159304442520633 909 2775 A potential DNA crosslinker. SGTC_2271 7849410 118.62 µM -0.997586465767784 0.162972477216193 no 2823 0.159239963315173 944 972430 SGTC_2653 dihydrofissinolide 100 µM -0.99845393359058 0.16274981377454 no 2824 0.159029645934477 943 6857746 SGTC_1967 st070177 51.4 µM -0.999043407707151 0.162598619298817 no 2825 0.158886831971542 950 5729214 SGTC_1045 1348-1485 165 µM -0.999093764406787 0.162585707524786 no 2826 0.158874635775314 927 6810614 SGTC_1362 1611-0397 101 µM -0.999470005787288 0.162489257984141 no 2827 0.158783530999142 940 27816 SGTC_98 0074-0023 107.663 µM -1.00084422093275 0.162137294120595 no 2828 0.158451063408051 936 3563821 SGTC_2228 7354201 200 µM -1.00120188344018 0.162045771111164 no 2829 0.158364608090843 950 753451 SGTC_2552 juarezic acid 87.02 µM -1.00177204410237 0.161899941091578 no 2830 0.158226851046941 935 1549512 SGTC_1627 st003713 25.6 µM -1.00420637470664 0.16127827437898 no 2831 0.157639575054959 938 16195070 YER133W GLC7 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.00462571046667 0.16117134401168 no 2832 0.157538556156868 937 5357218 A potent inhibitor of glutathione S-transferases. SGTC_73 0327-0325 16.231 µM -1.00807229698248 0.160294219440871 no 2833 0.156709877942175 879 53298 SGTC_2872 9044037 25.97 µM -1.00863263616021 0.160151913662489 no 2834 0.156575424713888 931 6465195 SGTC_1687 st020778 55.3625 µM -1.00985860958711 0.159840849111436 no 2835 0.15628151766828 930 4259299 SGTC_2203 7227154 166.4 µM -1.01017721748465 0.159760073914075 no 2836 0.156205196177557 936 896304 SGTC_901 1112-0062 60.1 µM -1.01174236393474 0.159363657430538 no 2837 0.155830627078255 915 1908457 SGTC_1393 3470-5649 58.2 µM -1.0130790124014 0.159025624675288 no 2838 0.155511211060683 920 4108395 SGTC_2534 helenine 20.12 µM -1.01406012901703 0.158777803614696 no 2839 0.155277030801474 922 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3016 9080866 49.47 µM -1.01513558362315 0.158506444643635 no 2840 0.15502060078073 937 17066299 SGTC_1024 4507-0395 26 µM -1.01568347362258 0.158368317924733 no 2841 0.15489007017217 930 4201836 SGTC_250 brefeldin a 552.239 µM -1.01624160091685 0.158227691533772 no 2842 0.154757175272083 934 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_447 ml7 120 µM -1.01634532961721 0.158201564964622 no 2843 0.154732484881976 952 4216 Selective myosin light chain kinase inhibitor. SGTC_3128 9127691 49.47 µM -1.01647246217418 0.158169547432614 no 2844 0.154702227256253 936 41316314 SGTC_3121 9125696 49.47 µM -1.01673946479834 0.15810231835283 no 2845 0.154638693198094 964 1235365 SGTC_2352 9027995 87.8 µM -1.01744011018562 0.157925990768863 no 2846 0.154472054573743 938 2997347 SGTC_1425 4048-4433 7.33 µM -1.01767770749037 0.157866225287569 no 2847 0.1544155723681 980 23734946 SGTC_2945 9067681 61.76 µM -1.02051718915799 0.157153128570274 no 2848 0.153741620646781 964 16456930 SGTC_47 0149-0135 24.25 µM -1.02173387171049 0.156848224790353 no 2849 0.153453437556108 941 5239155 SGTC_2893 9048488 25.97 µM -1.02212361699903 0.156750635989402 no 2850 0.153361198309588 955 6467338 SGTC_2424 5537928 59.2 µM -1.02865580144561 0.155120982702574 no 2851 0.151820723106251 929 5382802 SGTC_3172 9105863 49.47 µM -1.0293858034552 0.154939558759622 no 2852 0.151649208771242 962 2348785 SGTC_693 4161-2696 114 µM -1.02997644938045 0.154792870929833 no 2853 0.151510530509942 953 805759 SGTC_423 5-fluorouracil 457 µM -1.03064594791735 0.154626710904636 no 2854 0.151353440356754 921 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_664 1222-0054 14.9 µM -1.03121044007942 0.154486703593397 no 2855 0.151221072942698 928 6813991 SGTC_321 4534-3890 65.3 µM -1.03152396225537 0.154408978939406 no 2856 0.151147588596291 938 699746 SGTC_2787 5284540 71.43 µM -1.03365874006578 0.153880437886337 no 2857 0.150647864129402 952 736958 SGTC_2236 dapsone 200 µM -1.0352258453859 0.15349320755887 no 2858 0.150281725695393 926 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1337 1486-1011 40.3 µM -1.03690929214168 0.153077949003656 no 2859 0.149889066486415 921 X1337 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.03734930504419 0.152969533172738 no 2860 0.149786547611537 953 688798 SGTC_136 0097-0015 404.482 µM -1.0382201113346 0.152755123227599 no 2861 0.149583795831586 945 4861337 SGTC_3015 9080845 49.47 µM -1.03839322788975 0.15271252222873 no 2862 0.149543510549494 942 5296973 SGTC_1054 3429-0080 167 µM -1.04263064644271 0.151672223869139 no 2863 0.148559694917228 958 1162877 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.04333973983728 0.151498600543419 no 2864 0.148395485974637 926 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1327 1436-0082 2.18 µM -1.04372576715757 0.151404136341461 no 2865 0.148306142401634 952 15992205 SGTC_930 2810-3379 265 µM -1.04383194858745 0.151378159703341 no 2866 0.148281573694918 974 1015764 SGTC_616 4092-0450 108 µM -1.04464455208925 0.151179459360586 no 2867 0.148093640228067 955 787165 SGTC_299 1273-0059 1.44 µM -1.04494497635538 0.151106042634242 no 2868 0.14802420050283 908 2848077 SGTC_395 anisomycin 6.25 µM -1.04641861924479 0.150746262092901 no 2869 0.147683900008413 952 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1863 st057641 20.1 µM -1.04650054827886 0.15072627639059 no 2870 0.147664995960565 958 3921635 SGTC_3079 9117512 49.47 µM -1.04761064681413 0.150455653759537 no 2871 0.147409015063605 1000 7185044 SGTC_189 3970-0742 2.116 µM -1.04821419591565 0.150308654952975 no 2872 0.147269965749861 939 2891807 SGTC_2907 7721985 69.9 µM -1.05059040029296 0.149730843374417 no 2873 0.14672337596044 945 3267881 SGTC_2217 6934799 96.0675 µM -1.05171864444902 0.149457012513996 no 2874 0.146464327171964 938 675606 SGTC_1182 1222-0449 220 µM -1.05221689114518 0.149336191857101 no 2875 0.146350025785149 941 658318 SGTC_1534 6-azauridine 81.6 µM -1.05483952525233 0.148701300213245 no 2876 0.145749362132521 944 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1190 1486-1332 13 µM -1.05585926022683 0.148454928925465 no 2877 0.145516259615285 930 4150046 SGTC_2966 9084041 48.03 µM -1.05628996314709 0.14835095174279 no 2878 0.145417880036754 955 17741380 SGTC_419 nsc-638432 893 µM -1.05659481507656 0.14827738604352 no 2879 0.145348273924164 938 368090 SGTC_392 N-ethylmaleimide 8.33 µM -1.05743063382261 0.148075814666009 no 2880 0.145157548409388 925 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_119 0121-0043 24.815 µM -1.06096461262974 0.147225565448836 no 2881 0.144352991756689 947 1092378 SGTC_306 1672-3436 11.6 µM -1.06246273711917 0.146866117406465 no 2882 0.144012832884583 940 6797378 SGTC_2643 anethole 100 µM -1.06328359366032 0.146669417476655 no 2883 0.143826681517357 964 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2001 4023502 57.655 µM -1.06356545103316 0.14660191744491 no 2884 0.143762800210397 931 108941 YCR052W RSC6 SGTC_1936 st074407 74.3 µM -1.06356918119604 0.146601024274347 no 2885 0.143761954919412 964 809813 SGTC_595 3909-8003 73.7 µM -1.06434434524126 0.146415493995958 no 2886 0.143586368006373 961 699517 SGTC_2883 9059145 45.46 µM -1.06547296903983 0.146145647461163 no 2887 0.143330975770823 968 16476510 SGTC_949 1165-0505 146 µM -1.06598190025642 0.146024074701227 no 2888 0.143215911959126 950 6244267 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.0675091128525 0.145659664308586 no 2889 0.14287100040734 932 2346 DNA damaging agent; causes G2/M arrest. SGTC_317 4495-0002 170 µM -1.07006273351406 0.145051708139515 no 2890 0.142295536029185 932 15991618 SGTC_2470 5664817 21.68 µM -1.0721067894376 0.14456629963026 no 2891 0.141836034844454 959 2859561 SGTC_2458 5808907 16.39 µM -1.07288486767118 0.144381814802571 no 2892 0.141661388175937 943 2731747 SGTC_688 0527-0193 473 µM -1.07380836977991 0.144163055512214 no 2893 0.141454288941194 971 4007154 SGTC_3234 9132280 49.47 µM -1.07427688418225 0.144052159252941 no 2894 0.141349301101765 941 17612295 SGTC_2408 sulbentine 18.36 µM -1.0751973379756 0.143834457569415 no 2895 0.141143193505298 923 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1741 st038134 10.228 µM -1.07666858658022 0.143486945465947 no 2896 0.140814175551036 969 1272587 SGTC_1150 3909-7983 10.9 µM -1.07913695490934 0.14290518566938 no 2897 0.140263339656829 943 23965914 SGTC_2017 5132927 60.65 µM -1.08484351331524 0.141566339629527 no 2898 0.138995484809188 958 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1865 st057639 52.2 µM -1.08640934372426 0.141200462512851 no 2899 0.138648964756549 955 688818 SGTC_235 0330-0087 5 mM -1.08754067804046 0.140936510478387 no 2900 0.138398965694706 960 46494818 YHR062C RPP1 SGTC_2224 6650123 117.647 µM -1.09455690020498 0.139307029572137 no 2901 0.136855403209167 971 2908370 SGTC_1177 0983-0204 23.6 µM -1.09561293993673 0.13906288424122 no 2902 0.136624098235225 925 766818 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.09633786936607 0.138895456839097 no 2903 0.136465471361435 960 364106 SGTC_94 0334-0113 514.748 µM -1.10266640318413 0.137439668458247 no 2904 0.135086030938129 947 6795178 SGTC_1725 st036284 20.55 µM -1.10399707875132 0.137134896043147 no 2905 0.134797202447179 943 707914 SGTC_1301 naphtanilide LB 4.81 µM -1.10719166185579 0.136405107775829 no 2906 0.134105535893888 943 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1609 st001574 46.4 µM -1.10720522970708 0.136402013937191 no 2907 0.134102603496275 952 3960012 SGTC_2733 amorolfine 100 µM -1.10996378083272 0.135773986226263 no 2908 0.133507317114819 1000 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1848 st056003 16.4 µM -1.10999433946132 0.135767040180892 no 2909 0.133500732855838 925 146492 SGTC_1578 josamycin 24.2 µM -1.11172201552687 0.135374731308015 no 2910 0.133128845492993 958 5282165 A P450 substrate. SGTC_3242 9133940 49.47 µM -1.11469480945909 0.134701509733473 no 2911 0.13249061303093 964 17248444 SGTC_3191 9110352 49.47 µM -1.11525158164356 0.134575678491677 no 2912 0.132371313785004 940 17122424 SGTC_2370 9071495 200 µM -1.11837600128534 0.133871052505318 no 2913 0.131703219789637 981 21791103 SGTC_832 4083-0019 164 µM -1.11935654082446 0.133650442766243 no 2914 0.131494031745341 962 1990758 SGTC_1816 st051957 91.6 µM -1.12160705663038 0.133145049117696 no 2915 0.131014774976297 986 674121 SGTC_2280 7785178 200 µM -1.12175821178329 0.133111151718924 no 2916 0.130982629159948 941 2954328 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.12210265322725 0.133033930964973 no 2917 0.130909397955352 957 2724 A muscle relaxant with antifungal properties. SGTC_1964 st076914 61 µM -1.12480852299637 0.13242837132006 no 2918 0.130335091011719 969 24208661 SGTC_2378 9074213 121.43 µM -1.12631848493337 0.132091276660119 no 2919 0.130015368133947 955 657714 SGTC_802 4112-3352 742 µM -1.12947096841771 0.131389402236869 no 2920 0.129349604867761 943 704594 SGTC_78 0336-0123 156.75 µM -1.13067280148622 0.131122503197779 no 2921 0.129096416568379 945 6765896 SGTC_2842 9000675 19.48 µM -1.13090614454781 0.131070726603661 no 2922 0.129047298410076 937 2989072 SGTC_2231 micatex 6.853 µM -1.13328440862148 0.130543818100338 no 2923 0.128547418547221 983 20737 An antifungal of unknown mechanism. SGTC_1662 st014054 52 µM -1.13411173335077 0.130360866747492 no 2924 0.128373841236655 968 2838777 SGTC_88 0180-0332 8.668 µM -1.13744318269137 0.129625958524266 no 2925 0.127676531909997 957 3101745 SGTC_1326 1431-2094 10.8 µM -1.13909721387647 0.1292621520692 no 2926 0.127331304724808 966 616278 SGTC_2015 5119600 184 µM -1.13970156268065 0.129129401414079 no 2927 0.127205327956689 971 2828786 SGTC_1613 st002381 52.1 µM -1.14234935066306 0.128548905319447 no 2928 0.126654417736893 955 551167 SGTC_475 α-linolenic acid 10 µM -1.14385519963047 0.128219574915339 no 2929 0.12634184656099 950 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2572 astragaloside iv 100 µM -1.14413918950526 0.12815753182438 no 2930 0.126282958683013 954 45006101 An anti-inflammatory agent. SGTC_651 3253-0966 34.4 µM -1.14473507880172 0.128027416045277 no 2931 0.126159457813087 962 781462 SGTC_2147 5545932 89.7195 µM -1.14528190986472 0.127908093182474 no 2932 0.126046198595045 983 797404 SGTC_1152 3909-8331 15.9 µM -1.14635054576094 0.127675131492157 no 2933 0.125825068251268 946 16001939 SGTC_2895 9054447 58.44 µM -1.14637970955624 0.127668777947461 no 2934 0.125819037250168 991 2697450 SGTC_2987 9018338 71.43 µM -1.14702595669563 0.127528044706951 no 2935 0.125685446666397 951 5055682 SGTC_1290 0986-0249 10.2 µM -1.14906430127443 0.127084861237678 no 2936 0.12526473362509 969 53329 SGTC_303 1348-1668 34.2 µM -1.14906605978542 0.127084479359821 no 2937 0.12526437109453 965 5380509 SGTC_1454 4239-0054 42.6 µM -1.14928891939413 0.127036089679742 no 2938 0.125218432801868 957 1340767 SGTC_2480 5767542 37.17 µM -1.15052367557011 0.126768218455334 no 2939 0.124964124315848 945 2867358 SGTC_889 0919-1524 82.7 µM -1.15217979643851 0.126409553155487 no 2940 0.124623599019551 953 3905452 SGTC_200 k038-0079 37.545 µM -1.15237280047877 0.126367800409182 no 2941 0.124583956500487 992 3436683 SGTC_1667 st014849 34.6 µM -1.15327832934276 0.126172034805123 no 2942 0.124398080973564 961 5348460 SGTC_2334 9017922 200 µM -1.15350183075131 0.126123748748234 no 2943 0.124352233282206 956 3163164 SGTC_1340 1486-1359 257 µM -1.15684649966978 0.125402692848188 no 2944 0.123667540026336 939 4309068 SGTC_995 3931-2021 34.6 µM -1.15909217754901 0.124920178967824 no 2945 0.123209307044332 984 730143 SGTC_2135 5326629 150.42 µM -1.16128449571687 0.124450382781704 no 2946 0.122763111259576 973 5020077 SGTC_800 3448-7362 155 µM -1.1639621674983 0.123878256929629 no 2947 0.122219671955699 977 15991913 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.16479960810854 0.123699703345562 no 2948 0.12205005878135 984 61125 An anti-inflammatory. SGTC_2183 6420625 130.508 µM -1.16667577051109 0.12330033460928 no 2949 0.12167066561954 963 2897619 SGTC_2484 5809818 12.04 µM -1.16998589290697 0.122597931277225 no 2950 0.12100332298261 956 2870548 SGTC_2356 9061756 188.97 µM -1.1724707369783 0.122072498774619 no 2951 0.120504057058333 956 20104043 SGTC_1160 4092-0570 10.5 µM -1.17344772934753 0.121866342665192 no 2952 0.120308153274083 982 4994975 SGTC_1453 4237-0541 195 µM -1.17437954061333 0.121669948251789 no 2953 0.120121518214148 944 739892 SGTC_304 1310-0298 97 µM -1.17438745561606 0.121668280989146 no 2954 0.120119933770707 972 1550234 SGTC_3158 9100007 49.47 µM -1.17730747074385 0.121054287069858 no 2955 0.119536403078578 982 19297233 SGTC_801 0866-0028 10.1 µM -1.17752353648804 0.121008941524205 no 2956 0.119493304476331 964 6849771 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.17798541707667 0.120912047095717 no 2957 0.119401209991603 988 6708784 An antioxidant flavonoid SGTC_2132 5317594 122.667 µM -1.17863900430153 0.120775029295198 no 2958 0.119270976668047 977 794577 SGTC_1956 st077085 54 µM -1.17894717584847 0.120710462246342 no 2959 0.119209605417569 971 24208685 SGTC_3200 9114385 49.47 µM -1.18247531096618 0.119972990625923 no 2960 0.118508578092714 952 17018030 YLR208W SEC13 SGTC_2442 5158906 48.48 µM -1.18314775351117 0.119832793820236 no 2961 0.118375297505166 948 1893835 SGTC_1452 4194-0072 190 µM -1.18320383693617 0.119821106269538 no 2962 0.11836418635304 968 1343545 SGTC_384 k007-0144 5.16 µM -1.1847421092382 0.119500850073454 no 2963 0.118059713877807 982 6824886 SGTC_678 1218-2179 85.9 µM -1.18501246405569 0.11944462677746 no 2964 0.118006259442692 990 6820081 YOR116C RPO31 SGTC_2892 9047358 58.44 µM -1.19003787524147 0.118402932913007 no 2965 0.1170157529295 985 6466771 SGTC_917 harmaline 728.087 nM -1.19453654758535 0.117475885959457 no 2966 0.116134076593606 946 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_130 0136-0219 337.655 µM -1.19505462953384 0.117369455096089 no 2967 0.116032843404993 980 234244 SGTC_1504 k297-0033 30 µM -1.1996655775853 0.1164252242151 no 2968 0.115134623422119 922 4388117 SGTC_1459 k035-0031 35.7 µM -1.20047614059139 0.116259795419909 no 2969 0.114977236771447 940 3877128 YMR208W ERG12 SGTC_2665 lovastatin 100 µM -1.2010598615168 0.116140766455221 no 2970 0.114863990756226 983 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2110 5483698 200 µM -1.20148728573328 0.116053663474015 no 2971 0.114781117751536 964 2848765 YHR062C RPP1 SGTC_1815 st051655 58.2 µM -1.20165781599304 0.116018924774628 no 2972 0.114748065624332 972 5984156 SGTC_516 3992-2719 87.3 µM -1.20195414307225 0.115958577579243 no 2973 0.114690647701227 1004 5350887 YDR037W KRS1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.20225280599831 0.11589777724023 no 2974 0.114632797861301 1003 442882 SGTC_1710 st031758 61.5 µM -1.20240938061749 0.115865911589899 no 2975 0.114602478268384 978 5394341 SGTC_578 3460-0051 92 µM -1.20390765015533 0.115561302323708 no 2976 0.114312637301708 993 2876744 SGTC_3321 9137793 26.8275 µM -1.20433743140503 0.115474029724522 no 2977 0.114229592330633 973 4904192 SGTC_1366 1683-0113 21.9 µM -1.20523250986232 0.115292422914283 no 2978 0.114056777713039 992 708623 SGTC_515 4092-1064 102 µM -1.20623418292084 0.115089429436695 no 2979 0.113863603590023 1004 717353 SGTC_1622 st003707 19.4 µM -1.20849980465487 0.114631228981514 no 2980 0.11342753544269 950 10140899 SGTC_3043 9092303 49.47 µM -1.20916164604786 0.114497623192074 no 2981 0.113300374753799 970 25236084 SGTC_2086 5274770 176.623 µM -1.21147266120241 0.114031968398242 no 2982 0.112857153126681 955 689278 SGTC_1734 st037168 69.4 µM -1.21180297011716 0.113965523614697 no 2983 0.112793905557646 987 708907 SGTC_2798 7813637 45.45 µM -1.21300427782074 0.113724101741283 no 2984 0.112564092492838 969 956368 SGTC_2948 9070189 9.45 µM -1.21306492434813 0.113711923531355 no 2985 0.112552499540314 928 6473636 YDL196W YDL196W SGTC_1311 1190-0148 100 µM -1.21325935236482 0.113672887411435 no 2986 0.112515339192233 971 1961333 SGTC_3213 9129884 49.47 µM -1.21517437813305 0.113288910093304 no 2987 0.112149795212746 976 17190742 SGTC_769 0302-0231 76 µM -1.21519320505321 0.113285139750176 no 2988 0.112146205710969 999 571869 YER009W NTF2 SGTC_2267 7931562 200 µM -1.21905833590002 0.112512990046156 no 2989 0.111411025973124 980 934880 SGTC_2790 5423970 71.43 µM -1.21937924002726 0.112449051424387 no 2990 0.111350142811036 966 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1179 1021-1431 9.29 µM -1.21986585682807 0.112352144872868 no 2991 0.111257865448852 992 2840958 SGTC_1563 conessine 56.1 µM -1.22348299004713 0.111633686432606 no 2992 0.110573662488357 986 441082 An anti-amoebic, histamine inhibitor. SGTC_1949 st076024 69.1 µM -1.22754316062933 0.110831151471112 no 2993 0.109809255060431 984 2921930 SGTC_2120 5538279 151.968 µM -1.22802668604071 0.110735853788825 no 2994 0.109718475202376 990 2058197 SGTC_2234 tolnaftate 200 µM -1.22814442107959 0.110712658364978 no 2995 0.109696379103531 1003 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_12 0849-0099 9.267 µM -1.22916810916482 0.110511124454118 no 2996 0.109504391551824 961 6071388 SGTC_2134 5324836 1.464 µM -1.22962589212465 0.1104210856768 no 2997 0.109418614786996 995 699272 SGTC_1897 st060201 15 µM -1.23480266673512 0.109406553545033 no 2998 0.108451977330307 991 611878 SGTC_252 miconazole 1.30953 nM -1.23514058004517 0.10934056363482 no 2999 0.108389094484966 960 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3044 9093193 49.47 µM -1.23683112255679 0.109010852818017 no 3000 0.10807489258069 969 25236277 SGTC_2622 2-methoxyxanthone 59.94 µM -1.23725642180308 0.108928018242342 no 3001 0.107995950387431 985 71034 A hepatoprotective. SGTC_2062 5245942 200 µM -1.23871177533525 0.108644904681516 no 3002 0.107726128159474 1004 1376160 SGTC_171 k064-0041 9.68 µM -1.24022749702142 0.108350610581817 no 3003 0.107445630328097 958 53325 SGTC_1443 4112-3303 14 µM -1.24575831936417 0.107281606858184 no 3004 0.106426567930217 984 704433 SGTC_2869 9037858 32.47 µM -1.24736159870984 0.106973149561357 no 3005 0.10613247021932 978 27187042 SGTC_520 3584-0023 682 µM -1.24746830680304 0.106952642562883 no 3006 0.106112917068506 973 1340790 SGTC_1217 1183-1422 255 µM -1.2487210989576 0.106712094947104 no 3007 0.105883550519977 966 2849664 SGTC_3104 9120930 49.47 µM -1.25879014425378 0.104792915235864 no 3008 0.104053070572464 995 17014836 SGTC_1623 st003709 20.3 µM -1.26210589241497 0.104166430809888 no 3009 0.103455342632922 968 16192618 SGTC_2596 sinensetin 100 µM -1.26214365283899 0.104159311946025 no 3010 0.103448549966475 980 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2813 7971799 71.43 µM -1.26265400969914 0.104063130433545 no 3011 0.103356774384062 991 2234054 SGTC_3302 9125395 16.351 µM -1.26272323210672 0.104050089786036 no 3012 0.10334433092872 981 17599668 SGTC_947 3447-0010 211 µM -1.26289816120509 0.104017140582877 no 3013 0.103312890431592 989 748350 SGTC_3286 9117135 37.221 µM -1.26390905794895 0.103826878811267 no 3014 0.103131335142037 975 3438150 SGTC_2299 7976368 114.88 µM -1.26619316008702 0.103397915759056 no 3015 0.102721967868746 989 2979718 SGTC_3091 9116372 49.47 µM -1.26697050453194 0.103252221345338 no 3016 0.102582918329619 996 17169793 SGTC_1274 0865-0114 173 µM -1.26763429986477 0.103127927004395 no 3017 0.102464288537078 991 870624 SGTC_2305 7443522 69.23 µM -1.26874336664859 0.102920498991887 no 3018 0.102266304927975 957 5415886 SGTC_2478 5763493 32.33 µM -1.2725188836209 0.102216639114385 no 3019 0.101594409508718 973 1365576 YLR208W SEC13 SGTC_1802 st050112 57.9 µM -1.27274977265059 0.102173708960704 no 3020 0.101553424776772 991 4662563 SGTC_486 niguldipine 82 µM -1.27406525726882 0.101929365691885 no 3021 0.101320144981848 984 1236 A calcium channel blocker. SGTC_1829 berberine 14.4 µM -1.27592896329215 0.101583922070164 no 3022 0.100990315759744 939 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1262 0737-0114 49.6 µM -1.27753034443636 0.101287782813395 no 3023 0.100707537238559 992 765919 SGTC_3313 9133968 57.047 µM -1.27810732230073 0.101181238086063 no 3024 0.100605793743407 970 1494643 SGTC_1879 gemcitabine 100 µM -1.280274424263 0.100781790524904 no 3025 0.100224319628011 1004 60750 A nucleoside analog which inhibits DNA replication. SGTC_2689 tacrolimus 100 µM -1.28099329902546 0.100649539440462 no 3026 0.100098009894071 966 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_782 0083-0095 30.5 µM -1.28171739281644 0.100516456226892 no 3027 0.0999709006826837 991 3591729 An indicator and reagent. SGTC_2885 9057732 51.95 µM -1.282036924352 0.10045776948062 no 3028 0.099914846828163 984 6471414 SGTC_998 3996-0085 177 µM -1.28475863449006 0.0999588998688292 no 3029 0.0994383207618162 993 715391 SGTC_2105 5350118 200 µM -1.285033908118 0.0999085451435587 no 3030 0.0993902176019569 987 2133313 SGTC_1212 0520-0165 585 µM -1.28515029841316 0.0998872598968636 no 3031 0.0993698838987235 1012 5403258 SGTC_2714 st079313 56.9 µM -1.28560503642641 0.0998041299806622 no 3032 0.0992904690742907 985 2939799 SGTC_2728 chlorpromazine 9.18 µM -1.28735235192232 0.0994851762562027 no 3033 0.0989857519997525 1029 2726 A thorazine and dopamine antagonist. SGTC_3080 9117754 49.47 µM -1.287617201483 0.099436895899844 no 3034 0.098939624240911 984 9550191 SGTC_150 3970-0969 77.2 µM -1.28768281311972 0.0994249379716008 no 3035 0.0989281993628301 989 6615640 SGTC_2274 7947094 46.08 µM -1.29276167132402 0.0985024871970778 no 3036 0.0980467502992319 995 2971028 SGTC_619 1652-1634 108 µM -1.29362107254594 0.0983470197776433 no 3037 0.0978981700192027 1004 5400454 SGTC_2635 hydroquinidine 100 µM -1.29545065951325 0.0980166424497638 no 3038 0.0975824058843234 980 442912 An experimental heart treatment. SGTC_2385 9074692 200 µM -1.29646285879047 0.0978342145390833 no 3039 0.0974080340008755 997 17046906 SGTC_307 1501-1223 22.3 µM -1.29924855688819 0.0973334355050434 no 3040 0.0969293212400378 1000 2830329 SGTC_95 0471-0001 561.058 µM -1.29993603690903 0.0972101385059602 no 3041 0.0968114463061841 986 4015405 SGTC_1385 3091-4834 14.1 µM -1.3055273095239 0.0962116185734928 no 3042 0.0958566770754467 989 4072814 SGTC_1648 st011736 69.8 µM -1.30618055328561 0.096095452421759 no 3043 0.0957455821978883 997 2855514 SGTC_1419 3993-2473 62.6 µM -1.30800147760669 0.0957721823966372 no 3044 0.0954364040555439 1003 704026 SGTC_2938 9059746 27.26 µM -1.31091044483231 0.0952574123218214 no 3045 0.0949440108214815 1000 6471769 SGTC_1657 st012939 43.4 µM -1.31622951993768 0.0943214235503979 no 3046 0.0940485092399833 981 24207257 SGTC_2373 9071805 200 µM -1.31639192954723 0.0942929516975711 no 3047 0.0940212648915231 1011 10149009 SGTC_493 zm226600 134 µM -1.31933460926742 0.0937781711235394 no 3048 0.0935286361409924 1001 5240098 A potassium channel opener. YCR052W RSC6 SGTC_703 3875-0075 71.8 µM -1.3204356993984 0.0935860851706578 no 3049 0.0933447955387169 1033 2850814 SGTC_476 mead acid 10 µM -1.32062092809506 0.0935538004629135 no 3050 0.0933138955686888 1019 5312531 An omega 9 fatty acid. SGTC_1226 3909-7979 35.4 µM -1.32245122415989 0.0932352283924666 no 3051 0.093008970586126 992 6615510 SGTC_1926 methyl fluorone black 53.6 µM -1.32383787963182 0.0929944083609582 no 3052 0.0927784464046419 933 72721 Reacts with homocysteine. SGTC_1191 1487-1166 10.6 µM -1.32387204011162 0.0929884815295647 no 3053 0.0927727727418518 1029 3955771 SGTC_1880 MG-132 525 µM -1.32753799865982 0.0923540607410274 no 3054 0.092165389408443 978 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2007 4011539 71.82 µM -1.33309331119177 0.0913987868750227 no 3055 0.0912505920746718 983 45595301 SGTC_1221 2958-7315 257 µM -1.33601924545171 0.0908986067856541 no 3056 0.0907714914588933 1008 4562705 SGTC_1836 st055642 81 µM -1.34042993679991 0.0901484540201444 no 3057 0.0900528041943748 983 8571 SGTC_1042 0350-0096 82 µM -1.34389267244011 0.0895627558250313 no 3058 0.0894915479378487 1006 3122515 SGTC_2073 5212005 126 µM -1.34505526493196 0.0893667471015156 no 3059 0.0893036941223513 990 691789 SGTC_3178 9107506 49.47 µM -1.34640057743381 0.0891403309530434 no 3060 0.0890866824118663 993 8897194 SGTC_853 0419-0306 21 µM -1.3483263745764 0.0888169625375835 no 3061 0.0887767163896818 1003 762713 SGTC_851 0394-0702 453 µM -1.348683728757 0.0887570539462089 no 3062 0.0887192870150003 1008 762646 SGTC_1109 tnp00067 928.257 nM -1.3506383433256 0.0884299052089104 no 3063 0.0884056559186467 1004 676295 SGTC_2715 st079500 56.4 µM -1.35455232323661 0.0877775148728876 no 3064 0.0877801161268844 1005 28246688 SGTC_2098 5376439 882.5 nM -1.3549380276704 0.0877134196993726 no 3065 0.087718651269469 999 2844116 SGTC_2656 pseudo-anisatin 100 µM -1.35540686673143 0.0876355564933946 no 3066 0.0876439815349434 1037 6708809 A neurotoxin. SGTC_2882 9058044 58.44 µM -1.35777950762456 0.0872423070550974 no 3067 0.0872668296286287 981 18076804 SGTC_1029 k015-0030 64.7 µM -1.3586792780367 0.0870935211661597 no 3068 0.0871241206293695 990 2208316 SGTC_762 1165-0429 115 µM -1.35930176728064 0.0869906974047899 no 3069 0.087025492134991 987 5967793 SGTC_1986 st071812 45 µM -1.36055318289398 0.0867842610156936 no 3070 0.0868274676204861 1019 11838594 SGTC_411 enrofloxacin 100 µM -1.36615163926104 0.085865207284103 no 3071 0.0859456864847079 996 71188 A bacterial gyrase inhibitor. SGTC_553 k007-0256 45.7 µM -1.36751740950585 0.0856421090044023 no 3072 0.0857315920810937 1021 6287000 SGTC_208 k072-0098 12.366 µM -1.36917655001591 0.0853716729523169 no 3073 0.0854720471530881 1003 5948901 SGTC_2136 5328288 199.296 µM -1.37100568281837 0.0850742704628732 no 3074 0.0851865922638298 1007 262395 SGTC_966 1300-0360 30.2 µM -1.37448498263422 0.084510708172067 no 3075 0.0846455846302806 960 70588 SGTC_3074 9116018 49.47 µM -1.37651892860535 0.0841825579211927 no 3076 0.0843305155809633 1032 17027303 SGTC_3318 9139014 38.6185 µM -1.37688032124631 0.084124352205831 no 3077 0.0842746261351038 1000 16643984 SGTC_1358 1509-0022 2.48 µM -1.37718030764687 0.0840760595002196 no 3078 0.0842282542955472 997 3258434 SGTC_92 0063-0024 660.874 µM -1.38003716297991 0.0836171968670504 no 3079 0.0837876013846304 1038 3594437 SGTC_750 4073-0104 132 µM -1.38024316193254 0.0835841825845318 no 3080 0.0837558943325625 940 22330957 SGTC_1021 4476-0760 85.3 µM -1.38231248768114 0.0832530866828518 no 3081 0.0834378866561913 1014 746768 SGTC_1049 3226-0134 66 µM -1.38363538024121 0.083041938737238 no 3082 0.0832350645980337 1010 5702385 SGTC_1884 5633444 25 µM -1.38615519560015 0.0826408636195196 no 3083 0.082849759632904 993 5724239 SGTC_2587 piperic acid 92.2 µM -1.3863171209814 0.082615140147841 no 3084 0.0828250455869496 993 5370536 SGTC_1442 4112-3290 3 µM -1.38709862074434 0.0824910757939348 no 3085 0.0827058462756122 1024 704353 SGTC_2432 5630864 12.22 µM -1.38873076590587 0.0822324225332441 no 3086 0.0824573175461879 1006 5714970 SGTC_1992 st073643 23.3 µM -1.38903640326093 0.0821840548060034 no 3087 0.0824108403424756 1013 3161292 SGTC_1819 st053448 58.6 µM -1.39685809685579 0.0809535355093636 no 3088 0.0812281238010357 1029 2857616 SGTC_2270 7924575 90.91 µM -1.40101561154242 0.0803051563567664 no 3089 0.080604702373586 995 1262135 SGTC_1697 st025554 27.742 µM -1.40293651855407 0.080006912876113 no 3090 0.0803178849303356 1001 1269519 SGTC_1427 4048-4900 550 nM -1.40434665464231 0.0797885062077593 no 3091 0.0801078238828963 1011 24132586 SGTC_1439 4092-1168 46 µM -1.404654390697 0.0797409030035455 no 3092 0.080062037210099 1025 2886240 SGTC_957 1187-1561 14.1 µM -1.4067655960362 0.079414903074671 no 3093 0.0797484537109737 993 1538454 SGTC_960 1222-0186 7.7 µM -1.40994777239451 0.0789254375586024 no 3094 0.0792775525428569 1011 3126296 SGTC_1473 k844-0725 134 µM -1.41246560880983 0.0785397793858157 no 3095 0.0789064550495509 1004 54682906 SGTC_618 k072-0232 33.2 µM -1.41371559713401 0.0783488495020792 no 3096 0.0787227119663051 979 5872756 YGL099W LSG1 SGTC_1628 st004252 77.7 µM -1.41411918804419 0.0782872780970265 no 3097 0.078663455077298 998 692968 SGTC_885 0865-0106 16.8 µM -1.41474763796709 0.0781914755021655 no 3098 0.0785712507658828 1013 2793380 SGTC_3092 9117248 49.47 µM -1.41502753238013 0.0781488362773155 no 3099 0.0785302118630462 1039 17141857 SGTC_596 1155-0152 116 µM -1.41781547272221 0.0777250826661156 no 3100 0.0781223228013682 1008 280313 SGTC_1064 honokiol 6.76 µM -1.41813431519364 0.0776767314925511 no 3101 0.0780757772127843 1027 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3241 9133421 49.47 µM -1.42280142837913 0.0769715935285555 no 3102 0.0773968635941 1049 17018221 SGTC_1175 0741-0056 27.6 µM -1.42353696449139 0.0768609091539025 no 3103 0.0772902772023095 1020 765927 SGTC_2868 9035608 32.47 µM -1.42712066032931 0.0763233605391865 no 3104 0.0767725591409964 1018 6462614 SGTC_3120 9124077 49.47 µM -1.42727306412855 0.0763005637930626 no 3105 0.0767506007444201 1041 18774327 YGL155W CDC43 SGTC_1437 4092-1038 11.6 µM -1.43169176760652 0.0756418594181486 no 3106 0.0761160267313058 1014 3977136 SGTC_2749 bexarotene 57.39 µM -1.43305747465174 0.0754391498515444 no 3107 0.0759207064701498 1000 82146 An retinoic acid receptor inhibitor. SGTC_67 0335-0847 266 µM -1.43701154670811 0.0748545881623083 no 3108 0.075357356325885 1023 4552207 YOR254C SEC63 SGTC_2694 st077685 81.9 µM -1.43780346553686 0.0747379290102477 no 3109 0.075244912899011 1008 2838096 SGTC_1999 st074831 12.5 µM -1.44082131952388 0.0742946343007525 no 3110 0.074817584394329 1007 17112523 SGTC_3124 9127567 49.47 µM -1.44397067048961 0.073834167843185 no 3111 0.0743736128468647 997 17592030 SGTC_3317 9138495 8.753 µM -1.44412792907169 0.0738112323766008 no 3112 0.0743514965721935 1013 17020139 SGTC_168 3970-0862 530.542 µM -1.44535353093055 0.0736326703313454 no 3113 0.074179304429488 992 3135186 SGTC_1022 4477-0945 21.3 µM -1.44578043674902 0.0735705506037131 no 3114 0.074119397454277 1005 4648966 SGTC_365 0121-0052 13.6 µM -1.44986173174866 0.072978696200258 no 3115 0.0735485403629173 978 3101739 SGTC_2889 9059656 51.95 µM -1.45317062518073 0.07250153326014 no 3116 0.0730881929428131 1026 3949838 SGTC_3141 9094609 49.47 µM -1.45335227859183 0.0724754070802212 no 3117 0.0730629845350192 1021 25236309 YDL196W YDL196W SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.45490626938534 0.0722522000721717 no 3118 0.0728476059774525 1034 94937 An inhibitor of serotonin biosynthesis. SGTC_636 0kpi-0074 126 µM -1.45511868318439 0.0722217310502302 no 3119 0.0728182038489314 1018 616434 SGTC_71 0417-1750 47.813 µM -1.46303114682307 0.0710937545228285 no 3120 0.071729428207794 975 6811472 SGTC_1896 st058441 89 µM -1.4635034388178 0.0710268563151123 no 3121 0.0716648366757357 1002 688759 SGTC_2388 9080168 200 µM -1.47014517976098 0.0700911941544835 no 3122 0.0707612191276513 1019 15943073 SGTC_275 trichlorophene 5.69 µM -1.47259617518214 0.0697483129202867 no 3123 0.0704299783822497 991 62616 SGTC_521 r062-0005 13.8 µM -1.47435496278327 0.0695030645869408 no 3124 0.0701930219061292 1024 2832033 SGTC_1784 st039334 36.3 µM -1.48193676228352 0.0684534407889464 no 3125 0.0691785610633929 1010 3496984 SGTC_2036 5160441 105 µM -1.4840529329136 0.068162672215126 no 3126 0.0688974391981858 991 134534 YIL048W NEO1 SGTC_1529 apigenin 74 µM -1.48757931504579 0.0676802552904875 no 3127 0.0684309359197362 1002 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_814 3342-0569 96 µM -1.48871682548356 0.0675252052665262 no 3128 0.0682809762304916 1018 4346283 SGTC_1266 0828-0227 32.9 µM -1.49346101331693 0.0668814999453041 no 3129 0.0676582761039777 1033 3913820 SGTC_2636 apigenin dimethyl ether 100 µM -1.49428191268068 0.0667706012791511 no 3130 0.0675509753097349 1021 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1745 st081495 74 µM -1.49492982675072 0.0666831724190367 no 3131 0.0674663785288332 994 13842402 YBL026W LSM2 SGTC_1569 carminic acid 40.6 µM -1.49560687834396 0.0665919064586635 no 3132 0.0673780648290537 1024 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_794 k038-0031 316 µM -1.49739334958314 0.0663515558185546 no 3133 0.0671454688589651 995 6624242 SGTC_1736 st036774 51 µM -1.49993180751798 0.0660111894766655 no 3134 0.0668160338468941 1004 1272247 SGTC_2418 pentamidine 31.67 µM -1.50355510295255 0.0655277094107595 no 3135 0.0663479793748027 963 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2095 5432005 200 µM -1.5035561599146 0.0655275687751143 no 3136 0.0663478432086596 1032 783734 SGTC_1127 asiatic acid 681.4 nM -1.50631859230541 0.0651608083146829 no 3137 0.0659927037734608 1017 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_302 1094-0063 18.9 µM -1.50792315415522 0.0649485076024365 no 3138 0.0657870979314866 1019 5440289 SGTC_557 1315-0110 16.2 µM -1.51300057168096 0.0642802476051587 no 3139 0.0651397568212174 1019 6833801 SGTC_2930 9013230 14.89 µM -1.51507399080444 0.0640088978670205 no 3140 0.0648768337385984 990 2995857 SGTC_1723 st034307 2.5525 µM -1.51561518726673 0.0639382179102957 no 3141 0.0648083422673403 1006 867466 SGTC_1486 3970-0793 4.53 µM -1.52067593909839 0.0632802205767832 no 3142 0.0641705898048543 1033 2844330 SGTC_1082 camptothecin 424.86 nM -1.52164730231241 0.0631545294440746 no 3143 0.0640487392126142 978 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_6 0844-0013 19.835 µM -1.52254259780343 0.0630388534720933 no 3144 0.0639365901599798 1045 1584900 SGTC_1395 3486-0190 4.35 µM -1.52716071440945 0.0624447924013752 no 3145 0.0633605262567007 1033 6748079 SGTC_2446 5162541 200 µM -1.53036713505136 0.0620349017284021 no 3146 0.0629629395660666 1035 1549321 SGTC_358 0075-0058 9.45 µM -1.53541671785527 0.061393651772546 no 3147 0.0623407498988388 1036 1069125 SGTC_3147 9097027 49.47 µM -1.53736594556104 0.0611475076925497 no 3148 0.0621018604124633 1027 25236841 SGTC_2485 5633444 17.78 µM -1.53923578852415 0.0609121135585862 no 3149 0.0618733717443841 1024 5724239 SGTC_2161 5662504 8.5105 µM -1.54594882984457 0.0600728439466645 no 3150 0.0610584631765203 982 2859334 SGTC_2706 st078239 82.5 µM -1.54610648795145 0.060053242783061 no 3151 0.0610394260801701 1039 15434492 SGTC_1252 0493-0875 34.8 µM -1.54659920232904 0.0599920173506408 no 3152 0.0609799611000186 1022 3960963 SGTC_2603 homopterocarpin 100 µM -1.55078790771684 0.0594734948272751 no 3153 0.060476259709194 1020 101795 A weak amylase inhibitor. SGTC_767 0929-0023 86 µM -1.55421540793089 0.0590518212736361 no 3154 0.060066521708714 1028 1204563 SGTC_1526 st051518 75 µM -1.55609573120094 0.0588214898075235 no 3155 0.0598426649793454 1019 673993 SGTC_2438 5259590 200 µM -1.55759963255528 0.0586377763369725 no 3156 0.0596640929291784 1034 1201127 SGTC_3143 9086658 49.47 µM -1.56272110089676 0.0580155255070749 no 3157 0.0590591045127042 998 25236626 SGTC_2168 5727979 200 µM -1.56339522417782 0.0579340084548255 no 3158 0.0589798313940581 1034 695210 SGTC_1702 st027038 51 µM -1.56343588524108 0.0579290944748515 no 3159 0.0589750525517297 1033 5521182 SGTC_1433 4060-0023 7.6 µM -1.56409047452888 0.0578500309854327 no 3160 0.0588981613199723 1032 3840627 SGTC_1137 ixabepilone 100 µM -1.56616461851587 0.0576000690721231 no 3161 0.0586550417403867 1022 154225 A novel microtubule stabilizer. SGTC_1484 3473-2379 286 µM -1.56798707923985 0.0573811401248755 no 3162 0.0584420738887131 1069 671917 SGTC_2197 6588183 93.1375 µM -1.56944212354834 0.0572068187120676 no 3163 0.0582724776616418 1026 884136 SGTC_1328 1441-0025 69.2 µM -1.5773168639022 0.0562706076815865 no 3164 0.057361316984819 1025 4562601 SGTC_2206 7254556 146.969 µM -1.57775283150477 0.056219131402262 no 3165 0.0573112019371687 1029 4398905 SGTC_2777 climbazole 1.536 µM -1.58970076776084 0.0548227939648103 no 3166 0.055951135275099 1045 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3201 9113999 49.47 µM -1.59287780114487 0.054456150631578 no 3167 0.0555938035829706 1021 16649224 SGTC_2537 larixol 68.93 µM -1.59412119202763 0.0543131871089401 no 3168 0.0554544466155043 1023 6708759 SGTC_2877 9040724 71.43 µM -1.59475719115859 0.0542401756020105 no 3169 0.0553832716946008 1040 6463895 SGTC_707 0865-0008 204 µM -1.5961559181463 0.054079877582826 no 3170 0.0552269933634821 1047 723043 SGTC_2031 5180455 200 µM -1.59748995928961 0.0539273423143434 no 3171 0.0550782670341862 1037 29949 SGTC_405 ebelactone b 50 µM -1.60509976813479 0.0530637341750197 no 3172 0.0542359251650062 1030 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2227 7312221 64.1025 µM -1.60522662880668 0.0530494307282602 no 3173 0.0542219696267994 1060 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1546 5-methoxyflavanone 78.7 µM -1.6057461505301 0.0529908869336916 no 3174 0.0541648483405301 1038 147795 SGTC_1128 3448-9350 235 µM -1.60927447315157 0.0525946423184848 no 3175 0.0537781691260743 1026 619386 SGTC_472 calcifediol 10 µM -1.61099538177145 0.0524022324857882 no 3176 0.053590364515168 1055 5283731 A vitamin D metabolite. SGTC_2917 7979103 53.79 µM -1.61535379166429 0.0519174307313948 no 3177 0.0531170504386198 1031 2980565 SGTC_1719 st032227 49.2 µM -1.61863457491698 0.0515548538048931 no 3178 0.0527629556768361 1012 3125804 SGTC_2580 diallyl disulphide 81.36 µM -1.61882428846718 0.0515339492801619 no 3179 0.052742537321111 1026 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3185 9108267 49.47 µM -1.6225833383014 0.0511211280794589 no 3180 0.0523392523243664 1036 4910486 SGTC_2386 9075165 157.42 µM -1.62295810173867 0.0510801159948979 no 3181 0.0522991808762188 1036 16452277 SGTC_2618 avocadyne 43.43 µM -1.62592151879504 0.0507567371169057 no 3182 0.0519831758844198 1046 3015189 SGTC_533 1222-0222 6.71 µM -1.62978903362209 0.0503371543432097 no 3183 0.0515730461598126 1044 3982874 SGTC_1013 4112-3890 241 µM -1.63136813613628 0.0501666357998111 no 3184 0.0514063320690185 1026 705171 SGTC_631 k072-0230 41.5 µM -1.63144364582206 0.0501584934768841 no 3185 0.0513983708684537 1037 5773147 SGTC_2300 7976697 71.57 µM -1.63229628125704 0.0500666256099524 no 3186 0.0513085431323639 1020 2236109 SGTC_1051 3253-3903 78 µM -1.63240435015467 0.0500549912284939 no 3187 0.05129716666841 1028 5509239 SGTC_1412 3909-8563 178 µM -1.63377503547942 0.0499076142406822 no 3188 0.0511530480418944 1047 23767530 SGTC_870 0573-2213 57.6 µM -1.63939927928223 0.0493065118421058 no 3189 0.0505650658273434 1033 3916321 SGTC_215 1287-0124 461.5 µM -1.64003810805746 0.0492386028684188 no 3190 0.0504986218425072 1048 5560863 SGTC_2940 9060638 45.86 µM -1.641672280549 0.0490652264281206 no 3191 0.0503289696178092 1024 4027022 SGTC_984 1492-0255 2.91 µM -1.64839668027587 0.0483569316578806 no 3192 0.0496356484059859 1044 1585198 SGTC_391 gliotoxin 8.33 µM -1.64959419865453 0.0482316567417216 no 3193 0.0495129811729631 1035 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_433 pimozide 108 µM -1.65450661442235 0.0477204734466505 no 3194 0.0490123102513304 1043 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1512 0259-0544 12.2 µM -1.65578860936787 0.0475877860843003 no 3195 0.0488823176582983 1020 18476 SGTC_663 1486-0733 13.9 µM -1.65682209202905 0.0474810351959789 no 3196 0.0487777245734312 1041 722445 YPR165W RHO1 SGTC_983 1491-0821 12.2 µM -1.65765498193443 0.0473951436932899 no 3197 0.0486935625997656 1037 46495113 SGTC_1244 0416-0015 52.5 µM -1.6596129698727 0.0471937171455067 no 3198 0.0484961687290703 1045 96201 SGTC_544 k015-0020 52.4 µM -1.660955545734 0.0470559976567366 no 3199 0.0483611875947858 1042 3008304 SGTC_1887 st057648 70.8 µM -1.66113479376808 0.0470376350600476 no 3200 0.0483431889502199 1038 688672 SGTC_1957 st077035 62.4 µM -1.66113996021502 0.0470371058820845 no 3201 0.048342670256663 1055 705593 SGTC_2457 5731572 11.68 µM -1.66677782543153 0.0464624812526638 no 3202 0.0477792955411991 1036 2865357 SGTC_640 3381-0960 37.1 µM -1.66977316053885 0.0461594894819821 no 3203 0.0474821262541873 1051 1745025 SGTC_690 glyoxal 20.3 µM -1.67494030623318 0.045640540844248 no 3204 0.0469729721808871 1033 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1342 1486-1464 234 µM -1.67504586904425 0.0456299880138794 no 3205 0.0469626161744117 1036 3253938 SGTC_1990 st072050 59.8 µM -1.67915982544602 0.0452202524320667 no 3206 0.0465604496520455 1038 17233948 SGTC_2774 tamoxifen 10.92 µM -1.68413163696072 0.0447290335383168 no 3207 0.0460781157054549 1029 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2162 5663267 200 µM -1.68483667771198 0.0446597241554874 no 3208 0.0460100431811284 1043 6456493 SGTC_170 4197-0004 226 µM -1.68654525268743 0.0444921206102751 no 3209 0.0458454133295536 1040 218692 SGTC_1460 k062-0059 9.15 µM -1.69349113617728 0.0438159714327262 no 3210 0.0451810103191242 1031 1373085 SGTC_1545 lovastatin 49.4 µM -1.69665970978219 0.0435102910185304 no 3211 0.0448805070285202 1058 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3288 9119690 36.221 µM -1.69712533806916 0.0434655160766673 no 3212 0.0448364833774742 1057 17595618 YKL019W RAM2 SGTC_59 0330-0160 1.33 µM -1.69794093261715 0.0433871779229762 no 3213 0.0447594553383404 1050 4293482 SGTC_393 acivicin 6.25 µM -1.69814260413082 0.0433678248887666 no 3214 0.0447404251086674 992 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1063 disulfiram 1.84 µM -1.70300845182923 0.0429029918833144 no 3215 0.0442832433680206 1050 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_892 0929-0076 29 µM -1.70916819019493 0.0423203372524583 no 3216 0.0437098996518863 1031 5751038 SGTC_2425 5628681 7.85 µM -1.71062135864022 0.0421838183011304 no 3217 0.0435755167566462 1048 5714958 SGTC_2079 5212404 121 µM -1.71233691066498 0.0420231084668357 no 3218 0.0434172991287049 1039 758462 SGTC_124 0136-0217 7.121 µM -1.71360660040061 0.0419044856352611 no 3219 0.0433005002668385 1032 3976905 SGTC_1703 st026983 48.3 µM -1.71745771201724 0.0415463466589089 no 3220 0.0429477873373296 1035 1104023 SGTC_2427 5545055 42.75 µM -1.7298094988467 0.0404143789967307 no 3221 0.041832158385882 1043 5372858 SGTC_319 1348-1596 45.5 µM -1.74737622063532 0.0388477581647856 no 3222 0.0402860497562106 1046 5380505 SGTC_847 0342-0274 5.54 µM -1.7525045426936 0.03839985216773 no 3223 0.0398435447147539 1047 18097 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.75356514017265 0.0383077472900069 no 3224 0.0397525243132158 1060 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1713 st033146 12.748 µM -1.75373615190493 0.0382929130898632 no 3225 0.0397378639372892 1054 674619 SGTC_1740 st038286 13.222 µM -1.77011679098048 0.036893559751288 no 3226 0.0383538434754326 1035 716786 SGTC_2811 7967822 32.47 µM -1.77123463052207 0.0367996099751552 no 3227 0.0382608463612542 1032 2232244 SGTC_825 1988-2224 89.6 µM -1.77135285743222 0.0367896849443059 no 3228 0.0382510213976862 1050 1180859 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.77251581525764 0.0366921724242836 no 3229 0.0381544861860257 1039 165506 SGTC_760 0568-0725 82.9 µM -1.77804115430535 0.0362317640625065 no 3230 0.0376985479992064 1052 3916171 SGTC_2795 7780010 54.55 µM -1.78878234385143 0.0353502705812151 no 3231 0.0368249377508127 1031 953673 SGTC_993 3909-8757 62.7 µM -1.79002417335499 0.0352495018068521 no 3232 0.0367250126838535 1048 4288324 YLR208W SEC13 SGTC_630 4356-0227 183 µM -1.80264641216693 0.0342385746677289 no 3233 0.0357218815417017 1055 779312 SGTC_1347 1493-0251 600 nM -1.80605924100977 0.0339693686922281 no 3234 0.0354545432680168 988 3986378 SGTC_1 0258-0098 57.368 µM -1.80783655683689 0.0338298637765353 no 3235 0.0353159711423405 1014 6790032 YDR047W HEM12 SGTC_1203 3992-3522 103 µM -1.82947543751164 0.0321688819531963 no 3236 0.0336642078249057 1056 5322312 SGTC_1478 0453-0656 35.7 µM -1.83145440135058 0.0320203977183338 no 3237 0.0335163738855001 1071 5258496 SGTC_195 4234-0266 16.654 µM -1.8321051027101 0.0319716985580986 no 3238 0.033467881646031 1059 2303354 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.83547619777992 0.0317203806408639 no 3239 0.0332175813382122 1065 15053 SGTC_2801 7907800 81.82 µM -1.83928527808262 0.0314383770268023 no 3240 0.0329366186260129 1033 6620925 SGTC_1651 st011928 86.1 µM -1.83939757481988 0.0314300947425418 no 3241 0.0329283652871096 1063 720198 SGTC_2394 5221648 200 µM -1.84943597941262 0.0306969818592309 no 3242 0.0321974420794174 1066 788586 SGTC_1016 4226-1401 38 µM -1.86714147075985 0.0294384625186892 no 3243 0.0309409172306547 1054 2901613 SGTC_1857 st056007 79.3 µM -1.86794214079811 0.0293825779743633 no 3244 0.030885068083226 1062 619834 SGTC_2106 5357045 167.29 µM -1.86898381581948 0.0293100038325498 no 3245 0.0308125330310902 1066 668842 SGTC_3051 9093778 49.47 µM -1.8720807281453 0.0290951187454698 no 3246 0.0305977178908765 1077 17217378 SGTC_3089 9117425 49.47 µM -1.87781662664641 0.0287005798685855 no 3247 0.030203127464894 1065 9401657 SGTC_1339 1486-1321 22.7 µM -1.87932683499916 0.0285974445488452 no 3248 0.0300999398602857 1055 3469382 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.88865599379527 0.0279671488709829 no 3249 0.0294689694199216 1063 16486 A toxic proline analog. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.88881210356705 0.0279567010260555 no 3250 0.0294585051902721 1064 688803 SGTC_1587 estradiol valerate 56.1 µM -1.88921534551881 0.0279297285887655 no 3251 0.0294314896621365 1061 13791 A steroid. SGTC_2830 7992007 71.43 µM -1.89259047778898 0.0277048183727973 no 3252 0.0292061755297814 1048 1952075 SGTC_599 1935-0052 86.5 µM -1.90080749070587 0.0271635615153704 no 3253 0.0286636162853926 1061 9557311 SGTC_1916 st067606 49.2 µM -1.90139695299004 0.0271250749995434 no 3254 0.0286250191749657 1031 19590279 SGTC_952 1185-0122 232 µM -1.91046669096425 0.026538617318777 no 3255 0.0280365755731604 1045 678600 SGTC_1363 1636-0063 10.4 µM -1.91251432383088 0.026407691626568 no 3256 0.0279051285826665 1065 6072185 SGTC_1873 rapamycin 2 nM -1.91592205956081 0.0261909978256435 no 3257 0.027687508575793 1041 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1933 st074711 15.9 µM -1.91695438201179 0.026125647844071 no 3258 0.0276218636564192 1054 17250958 SGTC_2009 4012297 12.05 µM -1.92033194534754 0.0259127872845556 no 3259 0.0274079918567814 1039 45595307 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.92833248475358 0.0254143615330726 no 3260 0.026906891856224 1072 5106787 A p450 inhibitor. SGTC_1787 fluconazole 80 µM -1.93604398717961 0.024941567642148 no 3261 0.0264311569094527 1039 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_237 nikkomycin 200 µM -1.93971699692285 0.0247189806683494 no 3262 0.0262070463916103 1074 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1520 flindersine 88 µM -1.94493516428136 0.0244056234144432 no 3263 0.0258913910746099 1041 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2793 7325131 81.82 µM -1.9597096045098 0.0235364375057081 no 3264 0.0250148709653079 1053 4176441 SGTC_1588 farnesol 29.9 µM -1.96383591541276 0.0232983890631161 no 3265 0.024774561783993 1049 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2858 9025781 8.96 µM -1.9725888065161 0.0228001344792674 no 3266 0.024271214665565 1032 4894980 YPL153C RAD53 SGTC_1386 3228-0095 33.8 µM -1.97349144806602 0.0227492665316872 no 3267 0.0242197989738076 1059 870181 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.98388232786256 0.022170549259267 no 3268 0.0236344797155754 1065 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1097 itavastatin 7.23 µM -1.99863471845096 0.0213702954346659 no 3269 0.022823945526112 1068 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2448 5185112 27.17 µM -2.00323692756035 0.021125698590192 no 3270 0.0225759318867421 1062 5718189 SGTC_1696 st025591 34.7925 µM -2.01025271275166 0.0207573852109725 no 3271 0.0222022244618639 1059 2787147 SGTC_1488 4013-0813 75.9 µM -2.01367514075646 0.0205796975088231 no 3272 0.0220218258245049 1065 2910057 SGTC_1629 st005085 44.9 µM -2.01571150245739 0.0204745851284716 no 3273 0.0219150760627955 1052 24207091 SGTC_2788 5282734 71.43 µM -2.02016120835932 0.0202464836387385 no 3274 0.021683334286746 1057 743706 SGTC_3056 9094900 49.47 µM -2.02115885291815 0.0201956389664353 no 3275 0.0216316618152053 1072 25236784 SGTC_2152 5568786 200 µM -2.02593370051139 0.0199537868514123 no 3276 0.0213857895941345 1066 5399883 SGTC_1030 k029-0042 36.7 µM -2.027379314735 0.0198810510159387 no 3277 0.0213118178624548 1059 6080581 SGTC_1225 1216-0074 20.6 µM -2.02932604918472 0.0197834570013287 no 3278 0.0212125458915928 1071 4241466 SGTC_3134 9127454 49.47 µM -2.03515978126181 0.0194934311223337 no 3279 0.0209173991986562 1082 24262820 SGTC_1441 4106-0040 13 µM -2.03991381819908 0.019259760880199 no 3280 0.0206794551046117 1072 2904180 SGTC_248 streptozotocin 5.23457 mM -2.04511932180415 0.0190066348746218 no 3281 0.0204215479100783 1073 5300 DNA alkylating agent. SGTC_1583 clindamycin 39.6 µM -2.05731080652266 0.0184248558032907 no 3282 0.0198281692625527 1076 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1743 st037606 46.3785 µM -2.06306045154999 0.0181557883459024 no 3283 0.0195534425255125 1055 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2821 7996764 71.43 µM -2.07034429445319 0.0178197395318402 no 3284 0.0192100571974146 1041 2987135 SGTC_667 1498-1044 59 µM -2.0739450715292 0.0176555826284203 no 3285 0.0190422062432262 1074 6739982 SGTC_2624 nerol 100 µM -2.08410053640607 0.0171995383254215 no 3286 0.0185755116420123 1064 637566 A natural product oil. SGTC_244 nsc-207895 1.295 µM -2.08487342745823 0.0171652465704256 no 3287 0.0185403956493466 1063 42640 SGTC_3135 9127742 49.47 µM -2.093102525999 0.0168037446641572 no 3288 0.0181700016400322 1062 3643468 SGTC_744 1594-0068 283 µM -2.10125693314935 0.0164519672666386 no 3289 0.0178092090366621 1069 668392 SGTC_1912 st060209 90.8 µM -2.10519556584019 0.0162843268564062 no 3290 0.0176371440455633 1067 688787 SGTC_1842 st055362 61.2 µM -2.10535863152738 0.0162774179322135 no 3291 0.0176300509720384 1074 676032 SGTC_1806 st050005 60.3 µM -2.10544227779297 0.0162738749009807 no 3292 0.0176264134499178 1072 5194765 SGTC_795 0685-0265 78 µM -2.10760649034631 0.0161824340424466 no 3293 0.0175325208565833 1069 302754 SGTC_614 0462-0418 107 µM -2.11114559140718 0.0160338508141159 no 3294 0.0173798998659972 1046 5188303 SGTC_2440 5628896 157.78 µM -2.11795773048646 0.0157511440476276 no 3295 0.0170893238329419 1074 5522048 SGTC_555 4296-0685 37 µM -2.12227945874991 0.0155740159382465 no 3296 0.0169071386932285 1082 2908540 YHR072W ERG7 SGTC_1735 st034310 56.75 µM -2.14279588163266 0.0147562758277681 no 3297 0.0160647460822859 1065 871153 SGTC_613 3914-0030 117 µM -2.14548457997151 0.0146518969057351 no 3298 0.0159570615072568 1043 1145395 SGTC_2153 5569715 200 µM -2.17687750292974 0.0134794355187729 no 3299 0.0147448541964789 1080 2054701 SGTC_301 4119-0100 24.5 µM -2.18582787551017 0.0131603666884072 no 3300 0.0144141002702582 1075 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1431 4049-0260 9.09 µM -2.18793268329329 0.0130862880241489 no 3301 0.014337253079511 1076 3854841 SGTC_638 3970-0837 4.09 µM -2.1969401024587 0.0127733292661974 no 3302 0.0140123621463271 1069 4118451 YLR208W SEC13 SGTC_137 0438-0332 85.389 µM -2.2013246743573 0.0126233466551957 no 3303 0.0138565236516837 1058 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_615 k087-0205 167 µM -2.21554977317154 0.0121471972490237 no 3304 0.0133611759833996 1072 9642773 SGTC_1046 2001-0062 216 µM -2.2199364319762 0.0120035408489767 no 3305 0.0132115415067415 1078 739778 SGTC_127 0180-0333 59.125 µM -2.23723979336614 0.0114511554241957 no 3306 0.0126353359170551 1038 771601 SGTC_2822 7994718 71.43 µM -2.23965318892671 0.0113758933842659 no 3307 0.0125567233891843 1083 1018011 SGTC_2383 9036125 200 µM -2.25403197083689 0.0109363377818334 no 3308 0.0120970783803841 1080 79580 SGTC_582 0987-0078 156 µM -2.26662562629064 0.0105635686683151 no 3309 0.0117065526286904 1081 1625765 SGTC_260 nsc-65238 3.989 µM -2.27894802466742 0.0102095923734217 no 3310 0.0113350775662065 1082 3246252 SGTC_36 0335-0881 14.2 µM -2.28894564278546 0.00993004493415755 no 3311 0.01104125542793 1055 23828853 SGTC_909 3448-9333 149 µM -2.29564473957101 0.00974648916442289 no 3312 0.0108481012365632 1075 3344074 SGTC_818 4072-2707 53.5 µM -2.29646945788523 0.0097240980207862 no 3313 0.0108245267658217 1063 882871 SGTC_772 k072-0172 35.3 µM -2.30135569686146 0.00959235611063427 no 3314 0.0106857669671281 1067 5861980 SGTC_573 3702-0553 84.7 µM -2.31900748165333 0.00912934209207687 no 3315 0.0101973153311505 1078 1222756 SGTC_576 1073-0113 22.7 µM -2.3333730122113 0.0087670895897131 no 3316 0.00981428822167161 1074 5439563 SGTC_2832 7992762 51.95 µM -2.35027696175175 0.00835701624518578 no 3317 0.0093797233250315 1057 2985177 SGTC_162 k030-0015 37.8 µM -2.39196167493463 0.0074169562735738 no 3318 0.00837929611054461 1083 1809920 YMR134W ERG29 SGTC_377 3970-0964 33.1 µM -2.39956719621366 0.00725587202950984 no 3319 0.00820723339744991 1079 16481235 SGTC_34 0469-0683 81.75 µM -2.40891483277606 0.00706212132431576 no 3320 0.00800001562952809 1080 3690923 SGTC_160 3453-0671 289.699 µM -2.43326846312162 0.00657862012796251 no 3321 0.00748160096748211 1079 5322268 SGTC_1804 st050076 49.1 µM -2.4370918356561 0.0065054327597548 no 3322 0.00740295931693876 1085 3895976 SGTC_1357 1503-1303 39.5 µM -2.46852504096205 0.0059305307215701 no 3323 0.00678355796557099 1085 292895 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -2.48002567965201 0.00573172635149105 no 3324 0.00656864604640511 1088 66535 A nucleotide analog. SGTC_1690 st023502 41.2 µM -2.49044939011526 0.00555667183052455 no 3325 0.00637908323249492 1081 24207482 SGTC_1898 st060199 18.6 µM -2.49202502981681 0.00553062808049156 no 3326 0.00635085430596437 1075 688866 SGTC_3053 9095903 49.47 µM -2.5182605033527 0.00511263554630763 no 3327 0.0058968029340591 1092 17174018 SGTC_897 1000-0139 31.4 µM -2.53870436233974 0.00480666188576959 no 3328 0.00556318998039179 1084 6151020 SGTC_1669 st015249 58.4 µM -2.54959961471019 0.00465035910326198 no 3329 0.00539233480404727 1094 722793 SGTC_1372 2752-0194 270 µM -2.56714934306948 0.0044081123463545 no 3330 0.00512692199313376 1076 823334 SGTC_755 1995-0008 37.3 µM -2.58347473833869 0.00419295383248359 no 3331 0.00489053148723293 1090 689533 SGTC_1670 st016595 4.04 µM -2.62245020259352 0.00371679618348067 no 3332 0.00436500123323643 1091 597879 SGTC_1839 st053978 48 µM -2.63123753269015 0.00361638579942254 no 3333 0.00425372760368282 1094 3788398 SGTC_2857 9024691 58.44 µM -2.6530807953203 0.00337725534361301 no 3334 0.0039880388172899 1084 16478292 SGTC_524 r073-0010 27.8 µM -2.74614338680662 0.00250990696531583 no 3335 0.00301502013232648 1078 2772106 SGTC_1591 genipin 88.4 µM -2.80321451960279 0.00208323665892635 no 3336 0.00252980016491321 1086 442424 A DNA cross-linking agent. SGTC_1549 4'-methoxyflavonol 74.6 µM -2.80865185750155 0.00204623268939026 no 3337 0.00248747066385175 1092 97141 SGTC_2826 7992541 19.48 µM -2.80911440997046 0.00204311247144483 no 3338 0.00248389943663276 1085 2985066 SGTC_1199 1638-0010 4.46 µM -2.84413009143946 0.00181907404222846 no 3339 0.0022266430717742 1088 3111136 SGTC_3059 1327-0034 3 µM -2.92526522370131 0.00138327362586159 no 3340 0.00172081380011019 1086 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2417 cerulenin 830 nM -2.97704220622236 0.00115742986819097 no 3341 0.00145521970228021 1087 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1391 3442-0225 151 µM -2.99125645352927 0.00110163164589039 no 3342 0.00138916029314802 1091 5227075 SGTC_1189 1431-2119 7.28 µM -3.00227565839574 0.0010600840712285 no 3343 0.00133984701532989 1088 3107275 SGTC_2818 7996756 12.99 µM -3.02434925209714 0.000981146989697852 yes 3344 0.00124584306197348 1094 2241621 SGTC_2789 5281112 71.43 µM -3.0657797802916 0.000847380010692327 yes 3345 0.00108551576699497 1086 765948 SGTC_1682 st012968 530 nM -3.09887276988855 0.000752816038749414 yes 3346 0.000971292110759291 1084 24207270 SGTC_1785 bathophenanthroline 24 µM -3.14090543112141 0.000646725960856917 yes 3347 0.000842132039943561 1056 72812 An iron chelator. SGTC_852 0418-0143 439 µM -3.18021376605843 0.00056017129558767 yes 3348 0.00073583223452186 1076 5369229 SGTC_3062 9077494 49.47 µM -3.3227115772505 0.000328380016581944 yes 3349 0.000445735185543441 975 16459633 SGTC_908 3448-7491 47.7 µM -3.32601067013968 0.000324264982791093 yes 3350 0.000440492780282246 1072 1203031 SGTC_1822 st052468 42 µM -3.43377420497972 0.000213474052117842 yes 3351 0.000297619905956095 1094 2873678 SGTC_2414 st077232 92.9 µM -3.68367201634267 7.73374571892839e-05 yes 3352 0.000114949008133716 1089 729801 SGTC_376 3970-0862 59.1 µM -3.68598314711236 7.6591643728178e-05 yes 3353 0.000113910713795904 1092 3135186 SGTC_2755 lomerizine 42.69 µM -3.7891240855251 4.94225297786206e-05 yes 3354 7.55896953394784e-05 1089 3949 A calcium channel blocker. SGTC_1131 3454-3128 32.3 µM -3.93625100005882 2.5957102978769e-05 yes 3355 4.13822046414765e-05 1093 710982 SGTC_2419 paclitaxel 166.5 µM -5.64316496780677 2.82405987573082e-09 yes 3356 8.34761180206865e-09 1094 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase