SGTCid condition conc unit SWR1|YDR334W.score SWR1|YDR334W.strain.pval SWR1|YDR334W.strain.significant SWR1|YDR334W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2319 6033012 152.6 µM 21.9600029441541 4.2187773250007e-79 yes 1 3.47472731579324e-107 3 847246
SGTC_2174 5790901 200 µM 21.5264985759976 4.3006697058984e-76 yes 2 4.39656879531612e-103 3 786020
SGTC_221 trifluoperazine 10.304 µM 16.4857896074805 1.72196147238571e-45 yes 3 2.3209525694326e-61 18 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_210 3551-0445 56.827 µM 14.3941748506544 3.71516681445783e-35 yes 4 2.81463581987206e-47 9 2865180 YOR207C RET1
SGTC_2200 6600604 21.907 µM 13.2516068646371 4.26905944077861e-30 yes 5 2.20822363444476e-40 7 2904777
SGTC_1875 nocodazole 6 µM 12.4996622076759 5.4389094942922e-27 yes 6 3.74845783895886e-36 9 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1803 st050068 52.4 µM 12.1506030943697 1.3070101354751e-25 yes 7 2.84719904541296e-34 13 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1326 1431-2094 10.8 µM 11.6233210289742 1.34626022799193e-23 yes 8 1.5685009310417e-31 4 616278
SGTC_212 3807-4682 38.772 µM 11.2266402217769 3.85145713728926e-22 yes 9 1.50867484150314e-29 5 3125501 YBL034C STU1
SGTC_142 0335-0849 62.6745 µM 10.1605885200591 1.7957344385739e-18 yes 10 1.48638272889261e-24 27 3889043 YPR107C YTH1
SGTC_673 1082-0474 110 µM 9.71603177117285 4.76934525925201e-17 yes 11 1.28813231500612e-22 9 3098046
SGTC_2166 5933061 31.504 µM 9.55120499506537 1.55142273932843e-16 yes 12 6.40982028065184e-22 3 2877375
SGTC_2141 5621638 7.665 µM 9.45297028569993 3.10441668763387e-16 yes 13 1.64674728782313e-21 7 2856238
SGTC_825 1988-2224 89.6 µM 9.40392692626138 4.37768216455958e-16 yes 14 2.62819027407764e-21 6 1180859
SGTC_229 benomyl 22.8748 µM 8.87986174655344 1.54571647130609e-14 yes 15 3.34717566725258e-19 11 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1643 st009866 20.2 µM 8.87241730324809 1.62366902851883e-14 yes 16 3.57874962690926e-19 12 3156273 YOR207C RET1
SGTC_1754 st042065 16.137 µM 8.53440745304983 1.45342617622497e-13 yes 17 7.04377739216346e-18 49 1126236 YIL048W NEO1
SGTC_528 3492-0019 172 µM 8.34750007457749 4.71411125275026e-13 yes 18 3.48614933418098e-17 64 2869262
SGTC_2246 7293507 91.5585 µM 8.28152586483753 7.09846499525757e-13 yes 19 6.08034565823857e-17 6 887656
SGTC_1801 st050089 28.441 µM 8.19939547096223 1.17641182861198e-12 yes 20 1.20799447021397e-16 24 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_137 0438-0332 85.389 µM 7.93912762685571 5.64790781701992e-12 yes 21 1.01804093313645e-15 38 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_200 k038-0079 37.545 µM 7.91463733935781 6.52993724445389e-12 yes 22 1.23987425608502e-15 15 3436683
SGTC_928 2764-0428 58.7 µM 7.56390077915458 4.97659693572545e-11 yes 23 1.95579075424598e-14 7 662578
SGTC_1800 st050079 29.0735 µM 7.53682696658001 5.79991996099027e-11 yes 24 2.40772301664271e-14 17 3645560
SGTC_3294 9122953 26.2835 µM 7.4545690677267 9.20523101534262e-11 yes 25 4.50810174742435e-14 6 16459826
SGTC_367 0335-0881 7.1 µM 7.21933351882927 3.35817283595593e-10 yes 26 2.61214912792927e-13 15 23828853
SGTC_794 k038-0031 316 µM 7.02215540601105 9.63768712902979e-10 yes 27 1.0923566632407e-12 41 6624242
SGTC_1760 st045453 10.4495 µM 6.8787105473804 2.03927110068475e-09 yes 28 3.01983679599322e-12 68 3323419 YIL048W NEO1
SGTC_1788 fluconazole 20 µM 6.87840148663268 2.04253440021788e-09 yes 29 3.02639422692939e-12 25 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2125 5246583 200 µM 6.73497094079926 4.25831201790334e-09 yes 30 8.19813502363306e-12 12 835267
SGTC_286 k060-0067 22.9 µM 6.59666731493682 8.52819410066341e-09 yes 31 2.10251449808633e-11 7 5985051
SGTC_1090 efavirenz 20.7 µM 6.22893219935457 5.05841829286589e-08 yes 32 2.34812479698585e-10 3 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2352 9027995 87.8 µM 6.21816123774086 5.32145018323483e-08 yes 33 2.51507267881651e-10 12 2997347
SGTC_1712 st032288 53.4 µM 6.15925388623148 7.01131314068944e-08 yes 34 3.65442357499343e-10 74 2883011
SGTC_1930 st074634 34.3 µM 5.97832049723813 1.61053799068736e-07 yes 35 1.12724925354318e-09 12 684253 YOR116C RPO31
SGTC_3221 9128209 49.47 µM 5.8801020145462 2.50496861321643e-07 yes 36 2.05006852928917e-09 3 16460723
SGTC_216 k038-0035 28.382 µM 5.8767331735325 2.54289991272689e-07 yes 37 2.09220928067474e-09 23 4444231 YPR107C YTH1
SGTC_2651 TUB2.036 5 µM 5.85754086911766 2.76978974034271e-07 yes 38 2.34885617429778e-09 78 15992207 YFL037W TUB2
SGTC_227 fluconazole 33.516 µM 5.72429482350221 4.97754313056106e-07 yes 39 5.19321229738323e-09 43 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_375 3970-0961 9.27 µM 5.69749362131999 5.59189610539657e-07 yes 40 6.07907645723965e-09 5 2898222
SGTC_138 0850-0259 40.9225 µM 5.52755065400193 1.15588317834347e-06 yes 41 1.62366242366513e-08 124 6813004
SGTC_2077 5212015 200 µM 5.38188374904705 2.11916118733499e-06 yes 42 3.68551822042468e-08 31 780900
SGTC_2233 sulbentine 40.3845 µM 5.35627542733934 2.3538083237254e-06 yes 43 4.24774876087936e-08 30 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2090 5301565 104.445 µM 5.28553200841586 3.13846659340247e-06 yes 44 6.26699766405861e-08 24 2056344
SGTC_2952 9073731 13.78 µM 5.23145460771212 3.9011742513513e-06 yes 45 8.40906680659736e-08 12 16457353
SGTC_340 k038-0059 454 µM 5.22311241151983 4.03357575011564e-06 yes 46 8.79702539809683e-08 25 23733424
SGTC_2186 6124449 200 µM 5.1740100872845 4.90428805557805e-06 yes 47 1.14561223074354e-07 7 3834182 YLR033W RSC58
SGTC_789 1309-1135 70.6 µM 5.14960010740425 5.4013271361261e-06 yes 48 1.30521209180173e-07 12 3092424
SGTC_439 amiodarone 34.4 µM 5.11324024055961 6.23177130095033e-06 yes 49 1.58339563546908e-07 64 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_546 peri-Naphthalide 147 µM 5.05220684345519 7.90611046974443e-06 yes 50 2.18367182171905e-07 8 223824 A penicillin ester.
SGTC_556 4058-0063 51.5 µM 4.95591408445712 1.14474710961639e-05 yes 51 3.59955122557092e-07 15 6615692
SGTC_2396 5342950 42.78 µM 4.95284320606454 1.15821561711264e-05 yes 52 3.65684523846871e-07 24 1886677
SGTC_379 3970-0972 5.9 µM 4.90225786749768 1.40298939016392e-05 yes 53 4.73706781660934e-07 13 2898042 YBL034C STU1
SGTC_3288 9119690 36.221 µM 4.89044093806276 1.46687494795473e-05 yes 54 5.03051722440468e-07 14 17595618 YKL019W RAM2
SGTC_2161 5662504 8.5105 µM 4.87580161029941 1.54985745123284e-05 yes 55 5.41837394818326e-07 9 2859334
SGTC_149 3970-0822 46.1 µM 4.78947562663874 2.13743256008254e-05 yes 56 8.36088532978606e-07 54 3114250 YBL034C STU1
SGTC_514 4466-0038 2.65 nM 4.76820902497148 2.3117208802276e-05 yes 57 9.29354414305738e-07 118 5722064
SGTC_2254 7938975 95.19 µM 4.75356878364141 2.43944587480399e-05 yes 58 9.99285335957215e-07 35 2969277
SGTC_445 e6 berbamine 66 µM 4.71120412362648 2.84779855566624e-05 yes 59 1.23128713153596e-06 73 6610268 A calcium/calmodulin antagonist.
SGTC_2277 7947813 106.88 µM 4.66515255604311 3.36479770178949e-05 yes 60 1.54194079401376e-06 14 1246798
SGTC_3101 9120531 49.47 µM 4.63663335460334 3.7282369232821e-05 yes 61 1.77064877945555e-06 19 24824904
SGTC_3181 9108277 49.47 µM 4.63043340908075 3.81201531403827e-05 yes 62 1.82450562480932e-06 5 17097298
SGTC_1310 1188-0297 994 nM 4.58501694901295 4.48225618289303e-05 yes 63 2.26974805172873e-06 20 1588352
SGTC_2947 9072639 7.68 µM 4.56805131411286 4.76006669822464e-05 yes 64 2.46139765078459e-06 27 16488146
SGTC_1374 2889-5571 141 µM 4.55264677820747 5.02632720226953e-05 yes 65 2.64875880291968e-06 21 2853281
SGTC_788 1182-0090 188 µM 4.53347108916549 5.37742988506067e-05 yes 66 2.90111055151625e-06 62 5715185
SGTC_2098 5376439 882.5 nM 4.44950714047457 7.20550101407762e-05 yes 67 4.30337842999759e-06 7 2844116
SGTC_1903 st060211 78.3 µM 4.42855936946836 7.74530953008764e-05 yes 68 4.74323034623791e-06 12 688960
SGTC_2337 9009472 200 µM 4.40017263603231 8.53775102147505e-05 yes 69 5.40823957343562e-06 21 5742383
SGTC_172 1112-0046 2.638 µM 4.39907256355242 8.56994474978947e-05 yes 70 5.43572372436005e-06 29 2802135 YIL048W NEO1
SGTC_3216 9129716 49.47 µM 4.38664439489387 8.94167648412665e-05 yes 71 5.75563782728209e-06 16 8056934
SGTC_86 0417-1630 471.922 µM 4.38589028869843 8.96471309849062e-05 yes 72 5.77561678852338e-06 129 3634867
SGTC_1433 4060-0023 7.6 µM 4.34249920346855 0.000103883028109036 yes 73 7.04354982177106e-06 14 3840627
SGTC_2584 androsterone 48.74 µM 4.33001958192855 0.000108354924274818 yes 74 7.45480414985036e-06 103 2754130 A steroid.
SGTC_1463 k081-0032 34.1 µM 4.32206542751125 0.000111298834440695 yes 75 7.72876664209902e-06 2 977755
SGTC_604 1000-0114 314 µM 4.31709877005285 0.000113174947515044 yes 76 7.90467136317716e-06 12 1572745
SGTC_108 0509-0257 621.132 µM 4.29743800984437 0.000120896886617526 yes 77 8.63917797400478e-06 39 536624
SGTC_1818 st052136 56.3 µM 4.28614174073672 0.000125554426824193 yes 78 9.0901507513141e-06 37 674169
SGTC_207 4185-0010 4.486 µM 4.27508112799502 0.000130277433456488 yes 79 9.55338534053947e-06 79 3761753
SGTC_294 k038-0071 157 µM 4.26722958542945 0.000133730676641152 yes 80 9.89577255112333e-06 50 24152826
SGTC_635 k038-0028 24.7 µM 4.2009245104322 0.000166509732433575 yes 81 1.329136120336e-05 41 4035102
SGTC_449 xestospongin c 11.1929 µM 4.15868913317313 0.00019115967058188 yes 82 1.60039574562685e-05 58 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3282 9108498 15.4605 µM 4.15676435607138 0.000192360489880485 yes 83 1.61393311244285e-05 25 16459645
SGTC_1144 3486-0183 12.5 µM 4.1449440054206 0.00019989086100304 yes 84 1.69948378616974e-05 23 6744069
SGTC_1884 5633444 25 µM 4.14406932717926 0.000200458895638079 yes 85 1.70598260543895e-05 45 5724239
SGTC_3154 9100113 49.47 µM 4.12697576140072 0.000211867084338056 yes 86 1.83782559323505e-05 24 25237525
SGTC_1854 st056233 32.9 µM 4.02525461065153 0.000293289329190728 yes 87 2.84568511884647e-05 15 5393174
SGTC_2582 agaric acid 100 µM 4.01758062504052 0.000300486616977457 yes 88 2.93993602564095e-05 308 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_408 cantharidin 100 µM 3.99679131608264 0.000320818817493217 yes 89 3.21034275488474e-05 20 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_547 1120-0019 610 nM 3.98871938971313 0.000329052622256222 yes 90 3.32154738335031e-05 29 3676939
SGTC_2322 7413319 38.22 µM 3.97007142868835 0.000348831711600331 yes 91 3.59255441788978e-05 149 1840400
SGTC_1355 1499-0035 1.68 µM 3.93542162097581 0.000388546952709353 yes 92 4.15253829487564e-05 18 1548538
SGTC_366 0181-0206 4.31 µM 3.92511255307539 0.000401149605411154 yes 93 4.33445976366313e-05 45 274874
SGTC_1723 st034307 2.5525 µM 3.91717361546224 0.000411112224721843 yes 94 4.479661288429e-05 31 867466
SGTC_351 caspofungin 25 nM 3.91579693398883 0.000412863009682411 yes 95 4.50530338720586e-05 99 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_363 0455-0021 3.06 µM 3.9005438315043 0.000432729400598948 yes 96 4.7988423406262e-05 68 4597466
SGTC_535 2293-4129 48.2 µM 3.81836019884082 0.000555893243566364 yes 97 6.71708396725277e-05 66 396118 YIL048W NEO1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 3.77066663988993 0.000641493706680846 yes 98 8.14060209355069e-05 81 6708739 YPR165W RHO1
SGTC_2158 5657123 3.6195 µM 3.76623706577586 0.000650032319459324 yes 99 8.28632202233937e-05 9 2858827
SGTC_3350 9150499 3.57 µM 3.76040541136449 0.000661433608193807 yes 100 8.48191051921815e-05 62 4910996 YPR165W RHO1
SGTC_332 4112-0506 40.9 µM 3.75259423275418 0.00067699419335305 yes 101 8.75070059034824e-05 28 2790355
SGTC_2323 6148992 148.28 µM 3.66809375586435 0.000868301353887186 yes 102 0.000122182791218428 45 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2862 9027634 71.43 µM 3.62166839745622 0.000993459451613325 yes 103 0.000146354585797412 39 5012562
SGTC_271 rotenone 740 µM 3.59939868936788 0.00105919291831941 no 104 0.000159476931805851 40 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2461 5755302 26.15 µM 3.59937446032687 0.00105926655774213 no 105 0.000159491790376459 48 2788904
SGTC_422 cantharidin 155 µM 3.59901970637828 0.00106034530061563 no 106 0.000159709493307681 72 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_951 1171-0579 82.7 µM 3.59621957050942 0.00106889543257333 no 107 0.000161437649502173 102 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2109 5483026 200 µM 3.59611737334511 0.00106920868097489 no 108 0.000161501052227236 41 759335
SGTC_217 ketoconazole 989 nM 3.5935885456208 0.00107698674771758 no 109 0.000163077370416606 36 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3120 9124077 49.47 µM 3.5598454399085 0.00118585694071799 no 110 0.000185536563498138 31 18774327 YGL155W CDC43
SGTC_2061 5245884 80.95 µM 3.54060700849032 0.00125235021043625 no 111 0.000199603856851113 32 573863
SGTC_1352 1496-0991 99 µM 3.5245235668784 0.00131053784407289 no 112 0.000212122537490754 40 3000039
SGTC_399 oxolinic acid 75 µM 3.51278909967368 0.00135453958083253 no 113 0.00022171465119487 16 4628 A DNA gyrase inhibitor.
SGTC_2489 cantharidin 73.42 µM 3.51079697647826 0.00136214227592649 no 114 0.00022338273317404 62 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3224 9130643 49.47 µM 3.50883437313208 0.00136967041757628 no 115 0.000225037545090228 43 17644395
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 3.49134803793676 0.00143844154349176 no 116 0.000240294883347299 104 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_214 4373-3496 70 µM 3.46390861924618 0.00155273129129308 no 117 0.000266193665972731 90 3779166
SGTC_67 0335-0847 266 µM 3.45967548892503 0.00157108234390465 no 118 0.000270413368278976 146 4552207 YOR254C SEC63
SGTC_2738 aclarubicin 5.55 µM 3.40809772467843 0.00181111516315366 no 119 0.000327087309766549 18 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1136 pergolide 1.05886 µM 3.39868364981187 0.00185836725459141 no 120 0.000338554932337766 66 47811 A dopamine receptor agonist.
SGTC_945 3381-0768 11.3 µM 3.39601462278047 0.00187196633417816 no 121 0.000341873533296669 49 1126236 YIL048W NEO1
SGTC_2737 bleomycin 30.5 nM 3.37332829128521 0.00199125980995129 no 122 0.00037132674983449 114 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2242 6630449 61.2675 µM 3.37287606037868 0.0019937064561194 no 123 0.000371937141358822 60 691249 YDR170C SEC7
SGTC_1846 st056244 14.8 µM 3.36859764546925 0.00201698882996911 no 124 0.000377758151297502 56 5393182
SGTC_1687 st020778 55.3625 µM 3.35650963136074 0.00208410955052617 no 125 0.000394664858212713 204 4259299
SGTC_639 0833-0042 114 µM 3.33634037082878 0.00220062667214628 no 126 0.000424445814749789 73 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2407 paclitaxel 400 µM 3.28360615198028 0.00253368422627382 no 127 0.000512440197041232 63 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_589 1227-0070 34.1 µM 3.26794332352385 0.00264103489046391 no 128 0.000541660285475814 48 2841384
SGTC_3322 9139058 2.11 µM 3.26721478261402 0.0026461267554814 no 129 0.000543056226876812 55 4908926 YPR165W RHO1
SGTC_2912 7964298 10.93 µM 3.26489707854176 0.00266238451278679 no 130 0.000547519289915662 126 2975850
SGTC_3189 9110682 49.47 µM 3.26175499012787 0.00268456903877421 no 131 0.000553623996169655 59 17122418
SGTC_1652 st011932 78 µM 3.25559455480535 0.0027285495017755 no 132 0.000565776056914116 34 1551076
SGTC_3037 9091026 49.47 µM 3.22320788803799 0.00297064056409094 no 133 0.000633817588950592 180 25236398 YIL048W NEO1
SGTC_638 3970-0837 4.09 µM 3.2062289361818 0.00310514490130598 no 134 0.00067243472362913 74 4118451 YLR208W SEC13
SGTC_1364 1653-0028 37.6 µM 3.19768885554203 0.00317484943884888 no 135 0.000692668330486164 52 5718652
SGTC_2534 helenine 20.12 µM 3.18988564742959 0.00323976738175141 no 136 0.000711645497667418 30 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_735 3076-0345 636 µM 3.17934801518724 0.0033293287490847 no 137 0.000738033771371971 69 2888990
SGTC_158 k038-0087 26.446 µM 3.17229967291213 0.00339046997917176 no 138 0.000756184295896686 197 X158
SGTC_2084 5306078 60.6385 µM 3.16627376721651 0.00344354013003231 no 139 0.000772026999656062 47 679340
SGTC_2510 benzyl isothiocyanate 8.31 µM 3.16384047580455 0.00346518081064145 no 140 0.000778510564638009 41 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2822 7994718 71.43 µM 3.16102050326511 0.0034904132426585 no 141 0.000786087157247181 37 1018011
SGTC_582 0987-0078 156 µM 3.14834984517151 0.00360583560317218 no 142 0.000820975274388269 122 1625765
SGTC_806 3966-4455 5.86 µM 3.14833504856713 0.0036059723707814 no 143 0.000821016836309156 54 714982
SGTC_376 3970-0862 59.1 µM 3.13041189164941 0.00377509843816053 no 144 0.000872806777286596 50 3135186
SGTC_716 1683-5115 658 µM 3.12545833566416 0.0038230788411112 no 145 0.00088764108205605 54 723597
SGTC_1306 1185-0270 9.02 µM 3.12264593846331 0.00385056247490764 no 146 0.000896166107187853 77 1548076
SGTC_159 3970-0959 50 µM 3.11844845484662 0.00389191101468523 no 147 0.000909029698781679 150 6615653
SGTC_2249 haloperidol 116.36 µM 3.08262525034207 0.00426130411264732 no 148 0.0010259168209698 183 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1728 st035614 33.7865 µM 3.056403011076 0.00455124954333061 no 149 0.00112004970027283 108 15945546
SGTC_2845 9003024 42.97 µM 3.04375642919966 0.0046972816551158 no 150 0.00116822112019243 88 2990173
SGTC_2743 auranofin 4.32 µM 3.04127895251174 0.00472637427835334 no 151 0.00117787734229963 75 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3317 9138495 8.753 µM 3.02920629660909 0.00487045371608115 no 152 0.00122598593372928 62 17020139
SGTC_354 2783-3500 4.88 µM 3.02072784876974 0.00497396551247631 no 153 0.00126083950673719 100 6740761
SGTC_3200 9114385 49.47 µM 3.0095413335741 0.00511353635441741 no 154 0.00130821237586704 90 17018030 YLR208W SEC13
SGTC_377 3970-0964 33.1 µM 3.00393935200201 0.00518473215809594 no 155 0.00133254222369434 108 16481235
SGTC_2556 citropten 84.59 µM 3.00110102428496 0.00522114017131795 no 156 0.00134502650981122 83 2775 A potential DNA crosslinker.
SGTC_2269 7935389 174.42 µM 2.97726577241485 0.00553596789127841 no 157 0.0014541588781593 57 97605
SGTC_544 k015-0020 52.4 µM 2.9725426278656 0.00560031892372386 no 158 0.0014767209743427 56 3008304
SGTC_2229 7354935 190 µM 2.96562536157377 0.00569576301507344 no 159 0.00151034104032241 26 318112
SGTC_2997 9067075 71.4286 µM 2.95813703742522 0.00580071171069543 no 160 0.00154752248410117 104 27209819
SGTC_256 clotrimazole 625 nM 2.95421168016917 0.00585640805192874 no 161 0.00156734454813179 84 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.93427450918581 0.00614668083638326 no 162 0.00167164189511659 61 688669
SGTC_2949 9072542 2.23 µM 2.92566273013622 0.00627595598933349 no 163 0.00171861677790841 98 16457352
SGTC_1415 3966-0071 78.1 µM 2.90426858121277 0.00660758666658288 no 164 0.00184056112858582 39 2893185
SGTC_1493 4348-0038 111 µM 2.89146757259521 0.00681334123800942 no 165 0.00191723580766337 87 800424
SGTC_2335 9018011 154.17 µM 2.88070874875796 0.00699062749931081 no 166 0.00198391052962159 81 6458208
SGTC_734 2023-0417 80 µM 2.86975287745656 0.00717533313175263 no 167 0.00205396355632546 86 3935732
SGTC_3159 9100096 49.47 µM 2.86182812432576 0.00731160690341783 no 168 0.00210602627866917 74 25236875
SGTC_1361 1608-0041 5.61 µM 2.85204640000732 0.00748295560326698 no 169 0.0021719379688285 61 X1361
SGTC_3223 9129970 49.47 µM 2.85188050331014 0.00748589190721892 no 170 0.00217307177356296 71 17248386
SGTC_1395 3486-0190 4.35 µM 2.85182910365661 0.00748680186608451 no 171 0.00217342316832448 68 6748079
SGTC_3065 9113888 49.47 µM 2.85001690689551 0.00751894661481854 no 172 0.00218584526056433 68 16648368
SGTC_447 ml7 120 µM 2.82261127927516 0.00802010112250099 no 173 0.00238171439397993 81 4216 Selective myosin light chain kinase inhibitor.
SGTC_1627 st003713 25.6 µM 2.82052029551756 0.00805951691986132 no 174 0.00239729202412821 187 16195070 YER133W GLC7
SGTC_1661 st013063 9.66 µM 2.80900448807184 0.00827965973845061 no 175 0.00248474768998558 70 721395
SGTC_1396 3511-0007 98.6 µM 2.80138339290221 0.00842823695119876 no 176 0.00254420133477749 62 X1396
SGTC_1540 guanosine 70.6 µM 2.79641192434409 0.00852641493295768 no 177 0.00258367465524858 45 6802 Guanosine is a purine nucleoside
SGTC_1329 1447-1697 50.6 µM 2.77621924193845 0.00893557501242941 no 178 0.002749755496653 68 2840515
SGTC_1993 st073995 70.8 µM 2.76262985691315 0.00922052544019945 no 179 0.00286688742279651 70 3098394
SGTC_3356 9151811 4.48 µM 2.75464128542319 0.00939172034815565 no 180 0.00293782577148401 77 1859254 YPR165W RHO1
SGTC_733 4069-0007 56.1 µM 2.74761043896058 0.00954468495360274 no 181 0.0030015643894384 177 5717425 YNL287W SEC21
SGTC_871 0574-0004 149 µM 2.74413697247926 0.00962105503262157 no 182 0.00303351086650481 124 9551173
SGTC_1915 st067105 30.6 µM 2.72450099724774 0.0100629077428591 no 183 0.0032199367940517 127 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2765 myclobutanil 7.74 µM 2.71508781836496 0.0102809334529018 no 184 0.00331290990019885 118 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2378 9074213 121.43 µM 2.70772694111106 0.0104542832041552 no 185 0.00338728678561552 99 657714
SGTC_923 1900-2434 73.3 µM 2.70635443985939 0.0104868860729648 no 186 0.00340131986560514 105 5910570
SGTC_650 1328-0195 38 µM 2.69454928743036 0.0107709872414826 no 187 0.0035241950688483 94 2780821
SGTC_1331 1472-0049 76.2 µM 2.69109205232127 0.0108554470710517 no 188 0.00356092703716432 101 24051409
SGTC_722 3534-0461 190 µM 2.68506272903181 0.0110041224079276 no 189 0.00362580973087012 120 658262
SGTC_3045 9092950 49.47 µM 2.6824819909571 0.0110682995136359 no 190 0.0036539043160745 87 44120432
SGTC_2619 obliquin 87.91 µM 2.66094480869279 0.0116166930038227 no 191 0.00389608642862954 257 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1902 st060212 70.5 µM 2.66031756467056 0.0116330117036657 no 192 0.00390335033728137 96 688944
SGTC_2105 5350118 200 µM 2.65905598994169 0.0116658937530979 no 193 0.00391799697786307 96 2133313
SGTC_549 1661-1316 519 µM 2.6473338565838 0.0119753003278233 no 194 0.00405646071526106 93 2857282
SGTC_475 α-linolenic acid 10 µM 2.64225573849995 0.0121115316511082 no 195 0.00411779225122716 92 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2401 5128683 200 µM 2.63659617640573 0.0122649425559079 no 196 0.00418712286300553 112 708373
SGTC_580 1123-0028 41 µM 2.6254255351461 0.0125726865186343 no 197 0.00432703679970246 143 1677248 YPR107C YTH1
SGTC_969 1313-0238 134 µM 2.62079073200524 0.0127023212921324 no 198 0.00438630468493484 119 5212874
SGTC_2748 diazoxide 86.69 µM 2.61697579872417 0.012809890675489 no 199 0.00443563154174604 54 3019 A potassium channel activatior.
SGTC_3311 9131146 2.8755 µM 2.61174614661393 0.0129586307582391 no 200 0.0045040557377588 212 4900406 YPR165W RHO1
SGTC_2140 5586273 200 µM 2.60742245249164 0.0130827292671919 no 201 0.00456133658540376 58 854421
SGTC_1185 1319-0113 81.3 µM 2.59817539504709 0.0133515897218723 no 202 0.00468603044217914 73 4672763
SGTC_837 0091-0265 12.5 µM 2.59319329471347 0.0134984138128754 no 203 0.00475446552681706 112 759367
SGTC_3246 9135460 32.98 µM 2.58338582990229 0.0137915192068977 no 204 0.00489179211835725 51 41446951
SGTC_2018 5133068 143 µM 2.57971454606234 0.0139026425739586 no 205 0.00494410071144681 115 785362
SGTC_1413 3910-0535 34.4 µM 2.57267461893188 0.0141178897139832 no 206 0.00504580169170056 81 2876951
SGTC_566 0958-0068 16.5 µM 2.57139624067121 0.0141572829214835 no 207 0.00506446811366345 86 6815365
SGTC_2718 lomofungin 53.02 µM 2.57088078462488 0.0141731934636964 no 208 0.00507201199592995 73 5351222 A RNA synthesis inhibitor.
SGTC_1313 1220-0047 237 µM 2.56738417804339 0.0142815301942886 no 209 0.00512345074161026 127 3528706
SGTC_2720 fluspirilene 36.88 µM 2.56632428165773 0.0143145099271741 no 210 0.00513913437709118 61 3396 An atypical antipsychotic.
SGTC_398 bronopol 33.3 µM 2.55603644563132 0.0146380487555434 no 211 0.00529360146724332 114 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_196 k015-0023 18.111 µM 2.54707286261931 0.0149250514109796 no 212 0.00543153744571937 98 5211998
SGTC_3236 9132701 49.47 µM 2.54543578772786 0.0149779876589664 no 213 0.00545707175118466 102 24282524
SGTC_2346 9031566 143.75 µM 2.53391375788218 0.0153551477180349 no 214 0.00563982443017638 96 4771086
SGTC_2306 7482397 179.52 µM 2.53275859598124 0.0153934065319727 no 215 0.00565844303727742 108 891448
SGTC_401 neomycin 50 µM 2.50700824638703 0.0162677492994451 no 216 0.00608789355161504 80 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1293 1000-1278 195 µM 2.50008992772278 0.0165097847687159 no 217 0.00620808922280658 112 678847
SGTC_2833 9001315 45.46 µM 2.49978228948096 0.016520618612993 no 218 0.00621348245983788 159 2989378
SGTC_3247 9135149 49.47 µM 2.4995014889389 0.0165305126475278 no 219 0.00621840882437418 94 8934436 YOR116C RPO31
SGTC_3321 9137793 26.8275 µM 2.49418509961032 0.0167187953847856 no 220 0.00631233452653105 178 4904192
SGTC_2173 5763948 167 µM 2.48907497116558 0.0169014995724287 no 221 0.00640379773844456 95 2867177
SGTC_1545 lovastatin 49.4 µM 2.48331469562584 0.0171094930171283 no 222 0.00650830189480555 146 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1097 itavastatin 7.23 µM 2.47379500229029 0.0174580272496687 no 223 0.00668431909745073 130 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2041 5107442 45.335 µM 2.4621403608678 0.0178929637839634 no 224 0.00690553028059569 144 793005
SGTC_2191 5911152 200 µM 2.42585838097631 0.0193065890199156 no 225 0.00763611428294235 113 2875902
SGTC_1782 st039423 80.636 µM 2.41904647019042 0.0195823154577513 no 226 0.00778062605144535 143 2068169
SGTC_1959 st077091 55.8 µM 2.41159682853061 0.0198876765748884 no 227 0.00794141691238937 153 821356 YKL052C ASK1
SGTC_197 4544-0043 41.561 µM 2.4052865127101 0.02014948860628 no 228 0.00807989537327334 179 896523
SGTC_2645 abamectin 100 µM 2.40228032619855 0.0202752381822026 no 229 0.00814660861881229 128 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_313 3474-0040 5.03 µM 2.40081938357358 0.0203365896329394 no 230 0.00817920424710489 217 1043375 YIL048W NEO1
SGTC_3304 9125678 46.087 µM 2.38879922242257 0.0208473683197108 no 231 0.00845176861227272 175 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1870 st057514 26.5 µM 2.3807344257393 0.0211961237348533 no 232 0.00863908171200364 151 5393161
SGTC_1977 st070720 65.3 µM 2.36074782834261 0.0220817541366573 no 233 0.00911906381589101 109 682188
SGTC_1497 4476-2978 41.3 µM 2.35469083600422 0.0223562371512704 no 234 0.00926906104974718 166 1528379
SGTC_36 0335-0881 14.2 µM 2.35258120101817 0.022452512198452 no 235 0.00932180933548227 264 23828853
SGTC_555 4296-0685 37 µM 2.34820346017903 0.0226534101655786 no 236 0.00943210681842307 115 2908540 YHR072W ERG7
SGTC_3351 9150312 21.596 µM 2.33941148085607 0.0230614605636657 no 237 0.0096570739599627 155 4904905
SGTC_7 0192-1582 4.227 µM 2.33896362511991 0.0230824109172695 no 238 0.00966865805990453 224 252616
SGTC_2951 9072950 58.06 µM 2.33372976877626 0.0233284371026937 no 239 0.00980493814912134 152 16488155
SGTC_1965 Pectolinarigenin 58.4 µM 2.32943965870745 0.0235317433711641 no 240 0.00991789308016767 111 5320438 An anti-inflammatory.
SGTC_1522 st012842 45.6 µM 2.32925132038298 0.0235407026801379 no 241 0.00992287779507771 148 3491067 YOR116C RPO31
SGTC_2561 acetosyringone 100 µM 2.3251634939768 0.023735869908602 no 242 0.0100316097854129 172 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2083 5306046 65.942 µM 2.31351267941375 0.0242995992748594 no 243 0.0103472342272017 185 539837
SGTC_438 sphingosine 6.67 µM 2.30004434452243 0.0249652379383612 no 244 0.0107228539367724 124 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_305 1682-2595 20.8 µM 2.29979210559862 0.0249778486197727 no 245 0.0107300004623535 146 226033
SGTC_2937 9044753 11.33 µM 2.27311965803641 0.0263418068148684 no 246 0.011509485052065 198 6465530 YGL099W LSG1
SGTC_2255 7941087 197.44 µM 2.27021876684468 0.0264938353004512 no 247 0.0115971564487358 180 935561
SGTC_2123 5259487 200 µM 2.25992491586422 0.0270392391711728 no 248 0.0119129556220577 155 2173474
SGTC_2697 mebhydrolin 72.4 µM 2.25716816158556 0.0271868821062502 no 249 0.0119987845248639 238 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_585 0kpi-0023 191 µM 2.25712000615232 0.027189467122344 no 250 0.0120002885511927 140 64601
SGTC_1207 2099-0101 141 µM 2.24892109338524 0.0276325896724162 no 251 0.0122587583668421 167 5837381
SGTC_2092 5303694 80.6725 µM 2.23894271114838 0.0281799908017582 no 252 0.012579821978975 197 1963699
SGTC_2483 5729050 27.16 µM 2.23545882770816 0.0283732258703543 no 253 0.012693620864979 201 2865180
SGTC_43 0570-0105 72.5 µM 2.23113999744549 0.0286143010443189 no 254 0.0128359285208863 336 1114046 YDL195W SEC31
SGTC_1050 3232-1156 69.3 µM 2.22463513542739 0.0289806129980409 no 255 0.0130528709748588 165 700529
SGTC_2375 9072683 200 µM 2.22013734549677 0.0292361718549539 no 256 0.0132047229068974 189 16798029
SGTC_1311 1190-0148 100 µM 2.21962676428351 0.029265300392095 no 257 0.0132220569616838 198 1961333
SGTC_55 0767-0285 6.563 µM 2.21734548467335 0.0293957414449293 no 258 0.013299745969046 203 3116166
SGTC_459 nigericin 15.3 µM 2.20322773521087 0.0302137578968023 no 259 0.013789350700713 217 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2905 7799065 20.05 µM 2.20287020953388 0.0302347163145193 no 260 0.0138019489301511 129 1296806
SGTC_1705 st027868 56.3335 µM 2.19536353834677 0.0306775527249678 no 261 0.0140687652168554 147 292948
SGTC_1168 k815-0004 80.5 µM 2.19383853934664 0.0307681692897369 no 262 0.0141235095582664 154 642433
SGTC_3053 9095903 49.47 µM 2.1849788890481 0.0312990096979656 no 263 0.0144451972546316 96 17174018
SGTC_2754 granisetron 64.02 µM 2.18170837024249 0.0314968724551017 no 264 0.0145655313919022 200 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1680 diphenhydramine 100 µM 2.17925069550743 0.0316462385410247 no 265 0.0146565248729691 195 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3094 9117742 49.47 µM 2.17865906854039 0.031682282169691 no 266 0.0146785022947907 206 17149698
SGTC_1991 st073000 8.92 µM 2.17203301757443 0.03208828264268 no 267 0.0149265862865528 261 4301969 YIL048W NEO1
SGTC_2815 7968870 71.43 µM 2.15670899612591 0.0330437085424672 no 268 0.0155141728014292 212 2977326 YHR190W ERG9
SGTC_3167 9103034 49.47 µM 2.15385596235335 0.0332241532638027 no 269 0.0156257347031413 86 5127859
SGTC_996 3970-0799 1.8 µM 2.14582415020752 0.0337365009800581 no 270 0.0159435055518628 331 6615648 YGL040C HEM2
SGTC_938 3126-1755 342 µM 2.14420889106813 0.0338403192400617 no 271 0.0160080765007478 168 1777771
SGTC_1873 rapamycin 2 nM 2.13000533308987 0.0347645933536563 no 272 0.0165855865374098 256 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2040 5100729 123 µM 2.12939049029213 0.0348050667922314 no 273 0.0166109832958817 201 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2065 5221596 34.26 µM 2.12831020767301 0.0348762725736968 no 274 0.0166556861658476 184 788581
SGTC_1893 st059353 36.1 µM 2.11933298863727 0.0354726348543188 no 275 0.017031167812856 187 3112488
SGTC_1133 3473-0247 50 µM 2.11660673227834 0.0356553881643781 no 276 0.0171466191400295 247 711311
SGTC_2466 5983409 37.09 µM 2.11295468121025 0.0359014102688689 no 277 0.0173023234722879 172 2879657
SGTC_2452 5863136 48.41 µM 2.11037156703061 0.0360762612686042 no 278 0.0174131817768101 178 2184096
SGTC_796 1234-0020 70.7 µM 2.10987230713862 0.0361101364623756 no 279 0.0174346780803882 190 46495034
SGTC_3036 9090181 49.47 µM 2.10920298598259 0.0361555913154469 no 280 0.017463532148407 129 25236586
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.09634900016389 0.0370376561711149 no 281 0.0180256214891995 167 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3107 9121808 49.47 µM 2.08560966042118 0.0377880271434263 no 282 0.0185069977839212 114 662681
SGTC_972 1319-0219 195 µM 2.08462011334952 0.0378577879077732 no 283 0.0185518986414272 192 23903702
SGTC_1379 2144-0755 36.5 µM 2.08454406578465 0.0378631534298534 no 284 0.0185553531465832 224 5392327
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.07092181876524 0.0388343266813404 no 285 0.0191830514036942 166 229346 A bile salt which induces apoptosis.
SGTC_2380 9035439 200 µM 2.06865185510614 0.0389981147878356 no 286 0.0192893840653976 220 6462575
SGTC_897 1000-0139 31.4 µM 2.06637475398823 0.0391629825680122 no 287 0.019396553921445 168 6151020
SGTC_2066 5222451 176 µM 2.06317644113025 0.039395505932149 no 288 0.0195479338017818 265 2281147
SGTC_2930 9013230 14.89 µM 2.06294571304787 0.0394123236436421 no 289 0.0195588931285646 249 2995857
SGTC_1401 3807-4679 7.6 µM 2.06083215451568 0.0395666523556154 no 290 0.0196595278557164 176 3291456
SGTC_2685 mycophenolic acid 18.85 µM 2.05766590327178 0.0397987663433336 no 291 0.0198111077942802 139 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2958 9077254 16.72 µM 2.05580570142559 0.0399356508849974 no 292 0.019900624130164 215 16457351
SGTC_46 0329-0187a 2.197 µM 2.05234836897113 0.0401910779938253 no 293 0.0200679092131319 301 46494817
SGTC_3170 9103054 49.47 µM 2.04990075568912 0.0403727083234191 no 294 0.0201870582285785 185 16432970
SGTC_22 0964-0034 14.468 µM 2.04957366211406 0.040397031405845 no 295 0.0202030263841224 259 138402
SGTC_1024 4507-0395 26 µM 2.0489096255842 0.0404464465806428 no 296 0.0202354764680966 208 4201836
SGTC_685 1278-0033 54.9 µM 2.04077201948719 0.0410560125491587 no 297 0.0206367464909869 227 3590572
SGTC_127 0180-0333 59.125 µM 2.03596158182715 0.04141983930229 no 298 0.0208771065993446 286 771601
SGTC_64 000l-0018 272.079 µM 2.0277521325529 0.0420467737968682 no 299 0.0212927759973941 402 6811119
SGTC_3099 9120367 49.47 µM 2.02638586644702 0.0421518537338254 no 300 0.0213626290768935 183 24824940
SGTC_642 0335-0876 158 µM 2.01803200595909 0.04279898228062 no 301 0.021793964056857 235 6812350
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.01280913134155 0.0432076337210421 no 302 0.022067356459375 192 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_189 3970-0742 2.116 µM 2.00860776691665 0.0435386416090745 no 303 0.0222893734882779 154 2891807
SGTC_1067 clotrimazole 1.36 µM 2.00626471197004 0.0437241282352398 no 304 0.0224140064263301 242 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_958 1222-0007 33 µM 2.00512940956605 0.0438142328457648 no 305 0.0224746070757191 245 7312461
SGTC_2875 9039966 71.43 µM 2.00294991588479 0.0439876306991977 no 306 0.022591332275381 149 6463691
SGTC_2659 sanguinarine 24.21 µM 2.00247951724509 0.0440251275543383 no 307 0.0226165919410533 206 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_922 1866-0035 480 µM 1.99548466285981 0.0445857550359469 no 308 0.0229950226339543 310 3156169
SGTC_70 0141-0289 43.283 µM 1.99199470089013 0.0448676131551507 no 309 0.0231858196529615 491 352408
SGTC_1529 apigenin 74 µM 1.9917227603263 0.0448896358696052 no 310 0.0232007425149947 253 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_8 0354-0001 70 µM 1.98922348417615 0.0450924439064665 no 311 0.0233382704474337 324 4993152
SGTC_1373 2887-0003 58.5 µM 1.98340859031947 0.0455671574365644 no 312 0.0236609041810186 235 776948
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.98328688049193 0.0455771362927489 no 313 0.0236676970073071 217 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1106 tegaserod maleate 11.7 µM 1.98097105065666 0.0457673436472365 no 314 0.0237972600871579 253 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1171 0368-0077 21.4 µM 1.97931904803054 0.0459034179938876 no 315 0.02389004816263 197 3239779
SGTC_1765 st044815 90.4 µM 1.97613039870829 0.046166984092842 no 316 0.0240700051486257 236 645695
SGTC_2816 7982706 58.44 µM 1.9757477671874 0.0461986930055009 no 317 0.0240916759608075 265 2981853
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.97370372944246 0.0463683800763155 no 318 0.0242077204329766 229 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_994 3910-0338 138 µM 1.97343824752614 0.0463904558910402 no 319 0.0242228268100679 265 3479481
SGTC_672 1441-0018 53.7 µM 1.97303572713152 0.0464239430617149 no 320 0.0242457460137455 209 251141
SGTC_2647 atorvastatin 60.16 µM 1.97280244946683 0.0464433591792167 no 321 0.0242590369995565 213 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2180 6301957 200 µM 1.96741910844804 0.0468932379108645 no 322 0.0245674565932298 169 845462
SGTC_715 0868-0130 184 µM 1.96414194012085 0.0471688136441477 no 323 0.0247568168322283 189 2876258
SGTC_590 k048-0076 22.4 µM 1.9629180822014 0.0472720596869583 no 324 0.0248278466651006 203 6832814
SGTC_1198 1612-1005 86.7 µM 1.96115756821196 0.0474208962299318 no 325 0.0249303224684556 208 6998509
SGTC_1266 0828-0227 32.9 µM 1.94808484088599 0.0485378633520961 no 326 0.0257024061806238 234 3913820
SGTC_3166 9102297 49.47 µM 1.93985354398295 0.0492518930266746 no 327 0.0261987456294341 268 25237072
SGTC_3106 9121286 49.47 µM 1.93177956488487 0.0499604003488785 no 328 0.026693359686444 211 15943471
SGTC_1790 st045711 43.5 µM 1.92851742468739 0.0502489549225399 no 329 0.0268953995112657 215 585119
SGTC_1044 1222-0021 1.78 µM 1.92384051366157 0.0506649696126627 no 330 0.0271872887351274 263 4306703
SGTC_2829 7992743 58.44 µM 1.92185108723623 0.0508427601094526 no 331 0.0273122489709356 287 16462845
SGTC_2976 9009005 19.48 µM 1.91845753194939 0.0511471803958754 no 332 0.0275265110379036 226 2993148
SGTC_3279 9140807 49.47 µM 1.91376753454309 0.0515702839489936 no 333 0.0278249327428972 195 45595718
SGTC_586 0957-0265 8.15 µM 1.91024347510649 0.0518900310163716 no 334 0.028050935945266 185 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2311 7694451 200 µM 1.90847990080133 0.0520506351136117 no 335 0.028164609259031 254 2163142
SGTC_502 l-744,832 89.3 µM 1.90453452935925 0.0524113596685583 no 336 0.0284203020475699 245 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_731 3966-0296 387 µM 1.90265768328262 0.0525836545731135 no 337 0.0285426135161076 240 660956
SGTC_275 trichlorophene 5.69 µM 1.8961477117618 0.0531847574097306 no 338 0.0289702575394733 483 62616
SGTC_163 TUB2.036 7.546 µM 1.89581727065651 0.0532154136008415 no 339 0.0289921056647839 438 15992207 YJR013W GPI14
SGTC_1205 4161-2785 76 µM 1.89556780708631 0.0532385664975581 no 340 0.0290086087816794 241 3498106
SGTC_1622 st003707 19.4 µM 1.89430489421971 0.0533559009292836 no 341 0.029092275886153 309 10140899
SGTC_1953 st076800 12.1 µM 1.89277822380865 0.053498014007273 no 342 0.0291936843280508 304 297591
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.8880409402314 0.0539409031159602 no 343 0.0295102272494099 201 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_683 panaxydol 45 µM 1.88530092184112 0.0541983896951609 no 344 0.029694610887674 263 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2741 miltefosine 3.04 µM 1.8843069127263 0.0542920393563175 no 345 0.0297617364577152 195 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_534 k292-0788 63.4 µM 1.88227339714578 0.0544840240124282 no 346 0.0298994522918222 282 4146317
SGTC_2089 5281248 129.67 µM 1.87746799977471 0.054939836341916 no 347 0.0302269896111854 266 2737878
SGTC_165 k038-0023 64.381 µM 1.85814664928591 0.0568030347612924 no 348 0.0315740959018488 352 46368543
SGTC_2768 sulfasalazine 50.2 µM 1.85074193818049 0.0575301413577809 no 349 0.0321033437964749 253 5384001 An antioxidant and salicylic acid derivative.
SGTC_3243 9134147 49.47 µM 1.84826360552989 0.0577751301599442 no 350 0.0322821089815598 186 24282180
SGTC_470 aa-861 153 µM 1.84783227151515 0.057817852185749 no 351 0.0323133054114021 324 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2648 atorvastatin 78.68 µM 1.84775961238763 0.0578250512449905 no 352 0.0323185629636421 221 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_919 tnp00227 403.569 nM 1.83955645238161 0.058642360163874 no 353 0.0329166913649247 315 1269246 A methoxyflavone. YNL221C POP1
SGTC_1132 3456-3614 2.5 µM 1.83765732522785 0.058832863393245 no 354 0.0330564579589244 359 3125502
SGTC_1596 piperlongumine 63 µM 1.83736789375329 0.0588619391354574 no 355 0.0330778015977145 272 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1484 3473-2379 286 µM 1.83714362822409 0.058884476181726 no 356 0.0330943474897261 306 671917
SGTC_1711 st032263 62.8 µM 1.83350028964575 0.0592515543468153 no 357 0.0333641027656071 246 3958979
SGTC_2368 9071271 200 µM 1.83156908168933 0.0594468561623167 no 358 0.0335078233626485 290 27209959
SGTC_975 1335-0046 28.5 µM 1.83072094772844 0.0595327867157348 no 359 0.0335711023993748 305 16486740
SGTC_2177 5811945 192 µM 1.82366516197297 0.0602514378928228 no 360 0.0341013543763487 268 5343475
SGTC_708 3448-5400 146 µM 1.8207698926176 0.0605482867123078 no 361 0.0343209213590081 315 3462195
SGTC_3095 9117207 49.47 µM 1.81706804453224 0.0609294984686321 no 362 0.0346033475185423 195 17015229
SGTC_2802 7925815 54.55 µM 1.81627435567808 0.0610114753381067 no 363 0.0346641484990509 316 1262923
SGTC_12 0849-0099 9.267 µM 1.8147806969498 0.0611659830028917 no 364 0.0347788089880503 253 6071388
SGTC_1899 st063254 59.6 µM 1.8125833925252 0.0613938330543161 no 365 0.0349480505870997 238 3093813
SGTC_1565 sinapyl alcohol 95.1 µM 1.80403708635694 0.0622863540638701 no 366 0.0356127466284326 288 5280507 A phenol propionate derived from cinnamic acid.
SGTC_346 4513-0042 7.16 µM 1.80371639415183 0.0623200410418514 no 367 0.0356378890778621 310 2827372
SGTC_2271 7849410 118.62 µM 1.7994633812877 0.0627681419161744 no 368 0.0359727057107773 271 972430
SGTC_440 fluspirilene 35.1 µM 1.79251756113228 0.0635053528347966 no 369 0.0365250493544251 300 3396 An atypical antipsychotic.
SGTC_2662 daunorubicin 22.37 µM 1.78022740280934 0.0648262869523961 no 370 0.0375193762480449 256 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1534 6-azauridine 81.6 µM 1.78013183156594 0.0648366418124434 no 371 0.0375271941302995 345 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_430 0958-0115 16.4 µM 1.77472922036334 0.0654240894925619 no 372 0.0379713040626744 308 6833180
SGTC_3252 9135871 49.47 µM 1.76793749929602 0.0661684276067325 no 373 0.0385356764522031 270 17682838
SGTC_3198 9112019 49.47 µM 1.76626050929001 0.0663532231734252 no 374 0.0386760768145489 273 45595555
SGTC_1188 1403-0014 4.57 µM 1.76612505197284 0.0663681672908892 no 375 0.0386874356919436 370 9614867
SGTC_2766 oltipraz 83.91 µM 1.76608685552819 0.0663723817251525 no 376 0.0386906391753626 285 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2622 2-methoxyxanthone 59.94 µM 1.75280359637367 0.0678506065261801 no 377 0.0398178628158719 282 71034 A hepatoprotective.
SGTC_213 1246-0773 967 nM 1.75115118316311 0.0680362594417824 no 378 0.0399599358663581 324 6251622
SGTC_1287 0971-0001 34.6 µM 1.74949892414703 0.0682222869242873 no 379 0.0401024073031414 348 4665869
SGTC_3063 1327-0034 4 µM 1.74918598230145 0.0682575651555199 no 380 0.0401294381676281 293 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3132 9126706 49.47 µM 1.74756644093085 0.0684403625987189 no 381 0.0402695653262833 287 850858
SGTC_1421 4029-0249 71.4 µM 1.74748980616832 0.0684490217048347 no 382 0.0402762058111886 326 2894095
SGTC_2897 9048598 12.99 µM 1.74667115274753 0.0685415756447657 no 383 0.04034719852461 277 6467404
SGTC_1360 1598-0022 39.8 µM 1.74417109721962 0.0688248203095349 no 384 0.0405646297879075 380 761525
SGTC_697 0508-1955 564 µM 1.73596734619148 0.0697606087348367 no 385 0.0412848042392901 343 6243113
SGTC_3176 9106582 49.47 µM 1.72787442413393 0.0706933209771393 no 386 0.0420053702908538 141 17018027
SGTC_1539 benzyladenosine 56 µM 1.7205503261213 0.0715456598807086 no 387 0.0426662269800415 275 92208 A nucleotide analog.
SGTC_1023 4482-3888 16 µM 1.71917512389894 0.0717065741498841 no 388 0.0427912444884465 300 3303168
SGTC_1376 2910-0861 41.3 µM 1.71542138194818 0.0721472177222981 no 389 0.0431339989863564 346 1112859
SGTC_3218 9131285 49.47 µM 1.71334924275637 0.0723913491265235 no 390 0.043324154093545 385 17156417
SGTC_2214 7179297 48.276 µM 1.70816195921877 0.073005269928406 no 391 0.0438031474366063 243 769744
SGTC_13 0199-0087 65 µM 1.70799437579066 0.0730251698567323 no 392 0.0438186930307152 313 4589825
SGTC_2450 5739737 12.93 µM 1.70531117806261 0.0733443555552541 no 393 0.0440682019677674 312 2262825
SGTC_704 1310-0270 142 µM 1.6992328989319 0.074071356321402 no 394 0.0446376549608524 369 5718033
SGTC_1848 st056003 16.4 µM 1.69824694289175 0.0741898000564686 no 395 0.0447305819993822 325 146492
SGTC_3285 9112818 20.8695 µM 1.69709144532811 0.0743287950051507 no 396 0.0448396866529851 346 17017947 YPR165W RHO1
SGTC_488 nitrendipine 139 µM 1.69639790748674 0.0744123162001012 no 397 0.0449052748699278 332 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1831 st055328 12 µM 1.69590866082183 0.0744712781593035 no 398 0.0449515896110579 329 1103068
SGTC_2021 4019055 173 µM 1.69520968403762 0.0745555777825342 no 399 0.0450178252440051 520 44827708 YER133W GLC7
SGTC_1025 k007-0731 70 µM 1.69512101615964 0.0745662767159342 no 400 0.0450262330988271 319 6256118
SGTC_767 0929-0023 86 µM 1.69283364401513 0.0748426831638055 no 401 0.045243568367774 450 1204563
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.68830069240829 0.0753927543648625 no 402 0.0456767611950954 414 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_964 1287-0107 19.4 µM 1.68799921378049 0.0754294476275405 no 403 0.0457056899323328 365 51516812 YPR165W RHO1
SGTC_2252 omeprazole 400 µM 1.6868906947019 0.0755644836186947 no 404 0.0458121858406308 214 4594 A proton pump inhibitor.
SGTC_1386 3228-0095 33.8 µM 1.68393343230955 0.075925628309937 no 405 0.046097267161944 295 870181
SGTC_2916 7875993 68.79 µM 1.68286323244952 0.0760566458801049 no 406 0.0462007853447612 340 1299250
SGTC_3016 9080866 49.47 µM 1.67574045195755 0.0769330299442638 no 407 0.0468945213015016 343 17066299
SGTC_467 ro 31-8220 72.8 µM 1.67542132023815 0.0769724747045455 no 408 0.0469257981998332 400 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1901 st060216 58.6 µM 1.67254061794374 0.0773292261516328 no 409 0.0472088826725117 327 688792
SGTC_1378 2093-0007 380 nM 1.67203541326055 0.0773919208685315 no 410 0.0472586695548632 359 3618014
SGTC_712 r015-0009 80.6 µM 1.6715587210231 0.0774511126506919 no 411 0.047305685172896 297 6813872 YLR060W FRS1
SGTC_218 alverine citrate 93.75 µM 1.6667693250165 0.0780477304598408 no 412 0.0477801409875048 293 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1070 indatraline 8.81 µM 1.66476763417737 0.0782981128784939 no 413 0.0479795617488568 356 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1118 chelidonine 707.474 nM 1.66369300574134 0.078432784318201 no 414 0.0480868973636967 354 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2370 9071495 200 µM 1.65998254638092 0.0788991257942344 no 415 0.0484589818883144 350 21791103
SGTC_1141 3253-0389 52.6 µM 1.65701590479777 0.0792734907322726 no 416 0.0487581297823599 300 5402031
SGTC_2520 obtusaquinone 4.71 µM 1.65629645898498 0.0793644809544771 no 417 0.0488308986239245 328 5967872
SGTC_2060 5238662 140 µM 1.65472744293756 0.0795631927468245 no 418 0.0489898988646071 341 790130
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.65469066129484 0.079567855557974 no 419 0.0489936311819967 347 115019
SGTC_1388 3346-4487 254 µM 1.65344109147767 0.0797263864624571 no 420 0.0491205628942204 366 3345614
SGTC_1944 st076371 56.9 µM 1.65331567421092 0.079742311133222 no 421 0.0491333173124784 348 24208455
SGTC_3306 9127676 59.7925 µM 1.65214487846058 0.0798910872700038 no 422 0.0492525100478185 343 41905287
SGTC_2188 6126565 140.678 µM 1.64608730780799 0.0806641932408555 no 423 0.0498728925754648 269 874518
SGTC_2176 5809774 33.9695 µM 1.63830834248583 0.0816652644503349 no 424 0.0506786941388241 348 2870539
SGTC_2289 7946404 165.07 µM 1.63640898473045 0.0819111085885137 no 425 0.0508770100177019 462 1246120 YPR165W RHO1
SGTC_2402 5553605 200 µM 1.63608433659862 0.081953185303516 no 426 0.0509109689469597 366 6758546
SGTC_841 0251-0215 91.2 µM 1.63248623792042 0.0824206156822625 no 427 0.0512885476410108 425 3888614
SGTC_1721 st082152 9.2685 µM 1.62968187006354 0.0827863219667963 no 428 0.0515843755346741 319 5296051
SGTC_955 1216-0110 33 µM 1.62901370616435 0.082873634358885 no 429 0.0516550587326154 452 3619719
SGTC_2257 7960413 200 µM 1.62859517633524 0.082928361069029 no 430 0.0516993730443372 412 2974689 YIL048W NEO1
SGTC_2082 5219693 150 µM 1.62376651489968 0.0835617214308645 no 431 0.052212824539587 369 2834649
SGTC_995 3931-2021 34.6 µM 1.61896863511402 0.0841946375941789 no 432 0.0527270058824918 350 730143
SGTC_2052 5265182 7.135 µM 1.61817099848291 0.0843002063834927 no 433 0.052812875539303 370 1239884
SGTC_1412 3909-8563 178 µM 1.61616674040699 0.0845659122867191 no 434 0.0530291338109162 384 23767530
SGTC_2652 actinonin 100 µM 1.61207166617223 0.085110751417032 no 435 0.053473172773249 292 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1048 3161-0300 24.5 µM 1.60554599722748 0.0859844047001442 no 436 0.0541868495053464 392 2165101
SGTC_3180 9109287 49.47 µM 1.60540917395351 0.0860027940879657 no 437 0.0542018934032072 324 18891271
SGTC_2181 6316240 54.2555 µM 1.60163689704349 0.0865109571951307 no 438 0.0546179633505594 332 12779990
SGTC_1416 3966-0321 25.3 µM 1.59773475792315 0.0870389725065863 no 439 0.0550510099129929 375 582530 YLR208W SEC13
SGTC_385 1494-0393 12.4 µM 1.59687315673575 0.0871558832311789 no 440 0.0551469922372997 383 3090647
SGTC_1138 3761-0006 1.03 µM 1.59444208453286 0.0874863877786678 no 441 0.0554185263837732 317 12061087
SGTC_1240 0356-0016 42.1 µM 1.59286602744612 0.0877011521313291 no 442 0.055595124477424 377 4305613
SGTC_1806 st050005 60.3 µM 1.59222785670146 0.0877882254431307 no 443 0.0556667580950656 362 5194765
SGTC_45 0kpi-0036 14.9 µM 1.59041152223059 0.0880364027456211 no 444 0.0558710374047649 349 2795021
SGTC_3124 9127567 49.47 µM 1.58870793470056 0.0882696497863567 no 445 0.0560631733567048 343 17592030
SGTC_2259 7964009 200 µM 1.58813013492825 0.0883488638694541 no 446 0.0561284576428832 349 313134
SGTC_824 1304-0008 100 µM 1.58688220355405 0.0885201311117779 no 447 0.0562696631329143 425 768245
SGTC_2841 9004761 38.96 µM 1.58459169552132 0.0888351259433819 no 448 0.0565295664960334 347 2991039
SGTC_1495 4469-0029 237 µM 1.58426585556126 0.0888800037709305 no 449 0.056566616206678 523 793680
SGTC_979 1426-2828 121 µM 1.56825888932873 0.0911054730386347 no 450 0.0584103629958852 427 747872
SGTC_3112 9123419 49.47 µM 1.56770244728571 0.0911835725170766 no 451 0.0584752951419079 415 17015854
SGTC_1857 st056007 79.3 µM 1.56697197265336 0.0912861737083336 no 452 0.0585606214681826 334 619834
SGTC_846 0335-0850 148 µM 1.55717663492038 0.0926702893106026 no 453 0.0597142770754573 347 6819598
SGTC_1637 st007924 17.4 µM 1.54838729618017 0.0939254125478242 no 454 0.0607645389873342 386 683336
SGTC_486 niguldipine 82 µM 1.54781027246106 0.0940082486397034 no 455 0.0608339912700025 337 1236 A calcium channel blocker.
SGTC_2750 bromebric acid 70.15 µM 1.54707405775612 0.0941140160469822 no 456 0.0609226943547456 462 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2888 9058547 12.99 µM 1.54674325719263 0.0941615686913607 no 457 0.0609625838870983 306 16476514
SGTC_3289 9119912 71.43 µM 1.54560261505735 0.0943256721453058 no 458 0.0611002846336575 390 17014829
SGTC_3001 9076041 71.4286 µM 1.54139449275436 0.0949329165295972 no 459 0.0616104017872276 381 16004211
SGTC_1880 MG-132 525 µM 1.53704694317355 0.095563300400951 no 460 0.0621409071072958 356 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_676 falcarinol 140 µM 1.53638617925098 0.0956593785739062 no 461 0.0622218471948308 431 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1288 0973-0013 65.5 µM 1.53498602423107 0.0958632025135858 no 462 0.0623936305146582 404 4315430
SGTC_795 0685-0265 78 µM 1.53268778301332 0.0961984552134438 no 463 0.0626764003778349 426 302754
SGTC_1051 3253-3903 78 µM 1.53140055801452 0.0963866034853148 no 464 0.0628352131390931 441 5509239
SGTC_1092 toremifene 6.32 µM 1.53043385521446 0.0965280800718267 no 465 0.0629546871515027 459 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2491 paeonol 100 µM 1.52946355031364 0.0966702371812833 no 466 0.0630747842242947 343 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1424 4048-1941 275 µM 1.52349249943848 0.0975484278679583 no 467 0.0638177679042849 430 X1424
SGTC_1162 k048-0130 20.1 µM 1.5224275880932 0.0977056622520592 no 468 0.0639509882793675 397 6797406
SGTC_902 1120-0002 2.07 µM 1.52041848501213 0.0980028125739676 no 469 0.064202915775658 456 3280475
SGTC_3344 9148862 3.898 µM 1.51713560869079 0.0984897807040455 no 470 0.0646162247515426 387 4905352
SGTC_2585 alliin 100 µM 1.51098119653195 0.0994074699285279 no 471 0.0653966208512535 450 87310 A garlic compound which reacts with lipids.
SGTC_1621 st003705 32.4 µM 1.50796726015696 0.0998591536203907 no 472 0.0657814532828067 457 24207032
SGTC_1316 1272-0050 65.9 µM 1.50309586253677 0.100592372312575 no 473 0.0664071628033146 395 7340392
SGTC_2436 5633522 8.09 µM 1.50264346037843 0.100660664427597 no 474 0.06646550492801 442 5724242
SGTC_724 3910-0327 137 µM 1.49837538945751 0.101306613744868 no 475 0.0670178734184874 442 2885483
SGTC_2601 securinine 100 µM 1.49481579851728 0.101847643880431 no 476 0.0674812610163016 407 442872 A GABA receptor antagonist.
SGTC_852 0418-0143 439 µM 1.4944576969021 0.101902188751698 no 477 0.0675280154344442 510 5369229
SGTC_1783 st039459 87.517 µM 1.49412593457036 0.10195274067869 no 478 0.0675713532807318 467 729761
SGTC_3233 9132340 49.47 µM 1.49231899057911 0.102228392232328 no 479 0.067807770297857 424 17682950
SGTC_2312 7706453 155.7 µM 1.49109113104778 0.102416012829566 no 480 0.0679687852552172 427 976098
SGTC_2751 anetholtrithion 17.25 µM 1.48978164228324 0.102616382393883 no 481 0.0681408297831554 445 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1309 pyrazolanthrone 13.4 µM 1.48837228090219 0.102832352037569 no 482 0.0683263712556204 440 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_272 doxorubicin 8.13 µM 1.48653858733641 0.103113840227033 no 483 0.0685683590663751 488 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_202 3594-0513 34.79 µM 1.48640129539805 0.103134938250559 no 484 0.0685865036958451 375 708429
SGTC_2600 tangeritin 87.95 µM 1.48364787967854 0.103558725201839 no 485 0.0689511800774198 407 68077 A bioactive flavone.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.48176949971041 0.103848556834483 no 486 0.0692008186292417 439 5377381
SGTC_960 1222-0186 7.7 µM 1.47916980782274 0.104250655959219 no 487 0.0695474683489398 451 3126296
SGTC_2348 9022543 33.42 µM 1.47820896492833 0.104399556550834 no 488 0.0696759275401798 460 3162678 YDL140C RPO21
SGTC_364 0083-0097 67.7 µM 1.47081801801247 0.105550076412155 no 489 0.0706701691661267 431 5207356
SGTC_1809 st050081 57.6 µM 1.47051911401961 0.105596797774839 no 490 0.0707106063956429 413 5036894
SGTC_413 propylparaben 100 µM 1.46653535147263 0.106220923796006 no 491 0.0712512488324404 397 7175 A pharmaceutical preservative.
SGTC_2106 5357045 167.29 µM 1.46603977300661 0.106298750785155 no 492 0.0713187258844249 454 668842
SGTC_665 3914-0008 307 µM 1.45523354949832 0.10800604027747 no 493 0.0728023079417338 448 1069549
SGTC_1074 carmofur 3.8 µM 1.45423408007662 0.108164939654676 no 494 0.0729407097124354 500 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_273 hydroxyurea 18.1 mM 1.45320943798388 0.10832801569695 no 495 0.0730828062533128 514 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1156 4092-0367 4.88 µM 1.45211841905454 0.10850185030354 no 496 0.0732343406459645 463 1357585
SGTC_1248 0469-0687 58.6 µM 1.45130222291116 0.108632027910439 no 497 0.0733478612969494 462 4017482
SGTC_300 r073-0011 5.04 µM 1.45098844843364 0.108682102638684 no 498 0.0733915384251138 506 2735780
SGTC_316 k060-0003 58.6 µM 1.4272861089576 0.112512834815839 no 499 0.0767487214624533 448 6152314
SGTC_831 k061-1017 217 µM 1.42477251135641 0.112924665439735 no 500 0.0771114853791075 626 1240153
SGTC_1826 st055655 41.6 µM 1.42413548151357 0.113029207806427 no 501 0.0772036285335034 482 676168
SGTC_1934 st074720 32.6 µM 1.42398176861697 0.113054443825692 no 502 0.0772258748521 532 17250992
SGTC_1089 terbinafine 2.25 µM 1.41847761102481 0.113960747467439 no 503 0.078025685372499 444 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_854 0422-0053 192 µM 1.41753997377943 0.114115651538423 no 504 0.0781625579194188 458 3596728
SGTC_2189 6047310 154.431 µM 1.41650960902712 0.11428604772153 no 505 0.0783131764011723 437 711535
SGTC_666 0272-0154 136 µM 1.41628310946993 0.11432352927918 no 506 0.0783463155436408 507 6870312
SGTC_2395 5646831 180.19 µM 1.41251757650806 0.114947939192452 no 507 0.0788988095471401 464 6808628
SGTC_2721 ifenprodil 61.44 µM 1.41048874238295 0.115285369201584 no 508 0.0791977091189902 463 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_369 0957-0393 4.5 µM 1.40472270270142 0.116248203031276 no 509 0.0800518760560663 448 6997992
SGTC_2784 7567673 72.73 µM 1.40405165761542 0.116360626117955 no 510 0.080151733752425 512 3471247
SGTC_1651 st011928 86.1 µM 1.40265439238156 0.116594963477046 no 511 0.0803599618059172 470 720198
SGTC_2993 9054257 71.4286 µM 1.40205253377394 0.116696005105515 no 512 0.0804497798966055 508 6470217 YGL055W OLE1
SGTC_2763 lisinopril 49.32 µM 1.39935407750128 0.11714979230916 no 513 0.0808534153070288 426 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2939 9044578 71.43 µM 1.3971273094892 0.117525198178031 no 514 0.0811876453933072 475 2653634
SGTC_961 1252-1571 372 µM 1.39413938586774 0.118030262564408 no 515 0.0816377588076808 502 6813498
SGTC_2907 7721985 69.9 µM 1.38529590932071 0.11953411219603 no 516 0.0829810020307711 482 3267881
SGTC_576 1073-0113 22.7 µM 1.38472434871565 0.119631770077021 no 517 0.0830683854430484 665 5439563
SGTC_3067 9117431 49.47 µM 1.38157821458195 0.120170331657671 no 518 0.083550623472118 432 17150885
SGTC_2104 5389443 200 µM 1.38019863682359 0.120407028566648 no 519 0.0837627468074014 553 2244536
SGTC_2973 9094665 17.96 µM 1.379624152427 0.120505690778901 no 520 0.0838511985115893 545 25237061 YIL048W NEO1
SGTC_1511 0906-3109 28.5 µM 1.37516439035037 0.121273549038564 no 521 0.0845402427105953 601 2882180
SGTC_2479 5617353 43.85 µM 1.37300368649985 0.121646802354558 no 522 0.0848756003261468 497 2731746
SGTC_234 nsc-17383 10.7 µM 1.37265577424629 0.121706978246287 no 523 0.0849296920415901 540 408974
SGTC_2960 9079389 5.97 µM 1.36955882588418 0.122243557136228 no 524 0.0854123299548904 508 16457355
SGTC_567 1080-0542 68.4 µM 1.3679712574145 0.122519263014777 no 525 0.0856605365760814 444 5950415
SGTC_3292 9120825 59.784 µM 1.36643308915167 0.122786805655429 no 526 0.0859015344734677 496 24824900
SGTC_415 dibenzyl ketone 100 µM 1.36480664741801 0.123070147610434 no 527 0.0861569144836661 502 7593
SGTC_52 0329-0193 875 nM 1.36382678108407 0.123241070917266 no 528 0.0863110446715706 507 3739292
SGTC_3318 9139014 38.6185 µM 1.36088084325032 0.123755948149893 no 529 0.086775674172802 467 16643984
SGTC_2932 9016711 44.54 µM 1.35985303147866 0.123935938145687 no 530 0.0869382183346142 558 7117328
SGTC_383 2324-0395 7.37 µM 1.35963621493203 0.123973930363218 no 531 0.086972536003076 522 3146421
SGTC_978 1416-0512 87.4 µM 1.35825208716808 0.124216659682515 no 532 0.0871918539256694 561 6814003
SGTC_1345 1488-0192 31.4 µM 1.35747774738003 0.12435259768088 no 533 0.0873147296779776 513 658348
SGTC_2469 5655019 90.81 µM 1.35008019100297 0.125656509668971 no 534 0.0884951308336801 526 2788239
SGTC_766 1391-0721 126 µM 1.34005398010344 0.127438935736971 no 535 0.0901138980431067 510 1020919 YIL115C NUP159
SGTC_1563 conessine 56.1 µM 1.33921913302592 0.127588141097069 no 536 0.0902496727581826 615 441082 An anti-amoebic, histamine inhibitor.
SGTC_61 0978-8327 98.565 µM 1.33846847371012 0.127722403931439 no 537 0.0903718853432119 534 6150059 YHR072W ERG7
SGTC_184 1494-0393 24.714 µM 1.33821330013056 0.127768066604662 no 538 0.0904134573622577 540 3090647
SGTC_54 0159-0055 9 µM 1.33749601967702 0.127896482914522 no 539 0.0905303903306548 514 3319099
SGTC_1632 st005650 90 µM 1.33488172600673 0.128365284699284 no 540 0.0909575297938292 512 2759605
SGTC_2204 7233102 200 µM 1.33433863118128 0.128462823315546 no 541 0.0910464512307952 437 2172480
SGTC_1139 k015-0024 46.9 µM 1.33340559576895 0.128630514479324 no 542 0.0911993685293572 496 2766652
SGTC_2344 7990960 76.95 µM 1.33315848008327 0.128674953141637 no 543 0.0912399007635079 485 140813
SGTC_3051 9093778 49.47 µM 1.33095282297133 0.129072066995169 no 544 0.0916022673059813 433 17217378
SGTC_2688 kanamycin b 96.69 µM 1.32799471909783 0.129605986740117 no 545 0.0920899257502272 1036 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.32636452068249 0.129900880622096 no 546 0.0923594924065274 576 66535 A nucleotide analog.
SGTC_691 1548-0686 185 µM 1.31977486992123 0.13109764431471 no 547 0.0934550971273003 549 46495133
SGTC_610 4215-0184 155 µM 1.31729534025344 0.131549924221203 no 548 0.0938698232741904 568 5605015
SGTC_2024 5144227 134 µM 1.31527814143954 0.131918666053221 no 549 0.0942082207948854 576 3475211
SGTC_143 4032-1194 15.74 µM 1.31397882959095 0.132156556060502 no 550 0.0944266643269425 634 1806963
SGTC_2840 9008771 71.43 µM 1.30430827194111 0.133936423616868 no 551 0.0960642480339428 480 2992978
SGTC_2192 5915882 198.485 µM 1.30290399644003 0.13419624405585 no 552 0.0963037696910003 486 2876149
SGTC_3227 9130768 49.47 µM 1.30076967635808 0.134591800646489 no 553 0.0966686522101818 522 17720899
SGTC_1363 1636-0063 10.4 µM 1.29999267466936 0.134736001984038 no 554 0.0968017399231861 580 6072185
SGTC_1963 st076565 50.3 µM 1.29044643033844 0.136516313770805 no 555 0.0984478500544625 544 4914280
SGTC_1225 1216-0074 20.6 µM 1.28824786247845 0.136928601262113 no 556 0.0988298479207189 547 4241466
SGTC_2544 sphondin 68.51 µM 1.2860937843514 0.137333370294505 no 557 0.0992051665552219 526 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_59 0330-0160 1.33 µM 1.28175123959676 0.138151852227382 no 558 0.0999649620203188 712 4293482
SGTC_278 4092-0821 23.9 µM 1.27961622990832 0.138555475615111 no 559 0.100340069515126 555 877900
SGTC_2329 6138490 200 µM 1.27670658087035 0.139106836975916 no 560 0.100852928615141 502 720019
SGTC_1122 capsaicin 818.572 nM 1.27636688766029 0.139171304056092 no 561 0.100912927821799 569 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_187 1488-2104 32.728 µM 1.27620793087075 0.139201477906082 no 562 0.100941012919179 582 2852859
SGTC_2853 9015042 58.44 µM 1.27433726165948 0.139556910740888 no 563 0.1012719581757 524 6457456
SGTC_1137 ixabepilone 100 µM 1.27238977532751 0.139927594274782 no 564 0.101617332559593 627 154225 A novel microtubule stabilizer.
SGTC_16 erodoxin 22.806 µM 1.26915457182395 0.140544859133441 no 565 0.102192969924807 634 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1462 k081-0014 26.5 µM 1.26842937775256 0.140683476698044 no 566 0.102322327988426 414 3270634
SGTC_418 lividomycin a 100 µM 1.26574523571065 0.141197345353673 no 567 0.102802153704061 601 72394 An antibiotic.
SGTC_211 3455-0679 143.504 µM 1.25939992681374 0.142417185234932 no 568 0.103942957941903 594 748649
SGTC_1568 digitonin 820 nM 1.25645161086082 0.142986396336873 no 569 0.104476139756031 636 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_970 1315-0089 19.5 µM 1.25510337263709 0.143247202957798 no 570 0.104720618154648 549 6811083 YLR033W RSC58
SGTC_1958 st076513 41.9 µM 1.25216247200131 0.14381721240395 no 571 0.105255333784684 585 732122 YGL099W LSG1
SGTC_769 0302-0231 76 µM 1.25201558968797 0.143845721404886 no 572 0.105282091682451 678 571869 YER009W NTF2
SGTC_2911 7942208 15.64 µM 1.25100135949215 0.144042681624947 no 573 0.105466990720538 514 1243384
SGTC_1038 k292-0204 154 µM 1.24967737519017 0.144300068639853 no 574 0.105708712675965 538 4454212
SGTC_1648 st011736 69.8 µM 1.24825865039881 0.144576217403052 no 575 0.10596817582323 574 2855514
SGTC_25 0118-0223 35.662 µM 1.24522411143968 0.145168072026032 no 576 0.1065246909921 567 5333628
SGTC_228 caffeine 993.056 µM 1.2427517495284 0.145651483704515 no 577 0.106979663881184 539 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2088 5278280 127.392 µM 1.24207305007009 0.145784376386644 no 578 0.107104805443774 610 791502
SGTC_1317 1273-0028 910 nM 1.24118326198877 0.1459587246843 no 579 0.107269028330287 574 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_315 k915-0449 187 µM 1.24028352364354 0.146135165080152 no 580 0.107435272199592 683 20970215 YNL149C PGA2
SGTC_304 1310-0298 97 µM 1.23695424384916 0.146789288633446 no 581 0.108052035071375 589 1550234
SGTC_2661 dactinomycin 12.96 µM 1.23685802093878 0.146808223286214 no 582 0.108069898589861 634 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_303 1348-1668 34.2 µM 1.23610501720164 0.146956455226252 no 583 0.108209765089908 562 5380509
SGTC_1735 st034310 56.75 µM 1.23500714160911 0.14717275644176 no 584 0.10841392312842 594 871153
SGTC_2814 7977482 42.97 µM 1.23137231816238 0.14789040436502 no 585 0.10909182267593 671 6456762
SGTC_1792 st045773 43.6 µM 1.23111637619308 0.147941024868981 no 586 0.109139670750744 586 2919270
SGTC_745 0469-0705 296 µM 1.22905385498463 0.148349376052143 no 587 0.109525807377819 672 3486736
SGTC_1745 st081495 74 µM 1.22891474806932 0.148376944444966 no 588 0.109551885665353 657 13842402 YBL026W LSM2
SGTC_2699 st077704 54.6 µM 1.22837331667627 0.148484278658087 no 589 0.109653429924517 573 645852
SGTC_1477 0139-0234 16 µM 1.22362934876407 0.149426950534327 no 590 0.110546041465209 601 620880
SGTC_155 k072-0202 43.6 µM 1.22311250721641 0.149529892692372 no 591 0.110643602638723 574 5857737
SGTC_777 1315-0167 517 µM 1.22221773890282 0.149708220461655 no 592 0.110812648711709 575 4221767
SGTC_863 0466-0191 129 µM 1.22212349889204 0.149727010798005 no 593 0.110830463978782 656 765160 YPR165W RHO1
SGTC_3238 9133470 49.47 µM 1.22177219219132 0.1497970710365 no 594 0.110896893585 581 3534688
SGTC_232 clozapine 119 µM 1.22088410808016 0.149974276981382 no 595 0.11106495117463 596 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_844 0330-0132 15.3 µM 1.22055323412313 0.150040334418678 no 596 0.111127611090345 609 2828079
SGTC_1032 k061-1018 98.7 µM 1.21940336972137 0.150270050295867 no 597 0.11134556579579 690 4005393
SGTC_2896 9052656 71.43 µM 1.21891147234979 0.15036839136999 no 598 0.111438897435041 704 6469436
SGTC_2752 diclazuril 33.15 µM 1.21632173903132 0.150886842916246 no 599 0.111931191724006 784 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_489 paxilline 115 µM 1.21395454875776 0.151361782160216 no 600 0.11238254042601 561 105008 A toxic potassium channel blocker.
SGTC_2513 baicalein 25.65 µM 1.21162240169643 0.15183066173819 no 601 0.112828477672188 616 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2508 celastrol 40.54 µM 1.20848006841802 0.152463954386135 no 602 0.113431328960927 551 122724 Celastrol is a natural product and antioxidant.
SGTC_1387 3342-1166 1.8 µM 1.20372962957079 0.153424661427646 no 603 0.114347048119846 537 3418228
SGTC_3029 9088683 49.47 µM 1.20351920837631 0.153467308589376 no 604 0.114387731383955 607 25236615
SGTC_1507 4075-3230 155 µM 1.20083706820762 0.154011599786006 no 605 0.114907204878101 549 659771
SGTC_941 3237-0776 460 µM 1.20083144563827 0.154012742123315 no 606 0.114908295609796 587 760008
SGTC_2610 ononetin 44.17 µM 1.19912898683262 0.154358888486531 no 607 0.115238897235095 629 259632
SGTC_2890 9046729 58.44 µM 1.19872198771028 0.154441716258235 no 608 0.115318032716399 550 903329
SGTC_3272 9137413 49.47 µM 1.19764471671808 0.154661091821521 no 609 0.115527679908078 586 17614870
SGTC_454 lyso-paf C-16 6.67 µM 1.19603927728939 0.154988405570908 no 610 0.115840615976607 583 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1037 k284-1091 78.7 µM 1.19503547974769 0.15519329004786 no 611 0.116036584157041 567 3334711
SGTC_711 k292-0785 179 µM 1.19458356248561 0.155285588931931 no 612 0.116124887298946 618 4146315
SGTC_111 0083-0039 52.457 µM 1.18736348676901 0.156765118580722 no 613 0.11754213796949 481 759313
SGTC_1284 0929-0043 16 µM 1.18576611309447 0.157093699756754 no 614 0.117857338677467 644 1239883
SGTC_709 3807-1509 243 µM 1.18517373622035 0.157215667254575 no 615 0.117974380935061 618 1886677 YPL242C IQG1
SGTC_1216 1165-0504 9.65 µM 1.18365325690205 0.157529011442696 no 616 0.118275174664415 663 6304004
SGTC_2811 7967822 32.47 µM 1.18289601231075 0.157685219289744 no 617 0.118425181123426 637 2232244
SGTC_3331 9141060 1.957 µM 1.18131840320105 0.158010982365866 no 618 0.118738129592339 589 4906567 YPR165W RHO1
SGTC_3336 9143619 71.43 µM 1.17785627145565 0.15872743122837 no 619 0.119426955323425 688 45595730
SGTC_1645 Cervolide 78 µM 1.17545139580805 0.159226344435702 no 620 0.119907085809417 589 23173 A fragrance.
SGTC_17 0960-0276 49.807 µM 1.17177311751404 0.15999142121448 no 621 0.120644079168816 684 6821114
SGTC_633 0437-0093 97.7 µM 1.17085188796465 0.160183411509386 no 622 0.120829158441615 626 2831118
SGTC_1124 fisetin 1.16336 µM 1.16975267568407 0.160412691559091 no 623 0.121050256623254 588 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_347 4534-1311 26.2 µM 1.16931422815094 0.160504205275768 no 624 0.121138526365241 648 2862016
SGTC_3138 9097216 49.47 µM 1.16816492742883 0.1607442516546 no 625 0.121370122337653 628 25237486
SGTC_2128 5255449 168.493 µM 1.16670868892587 0.161048742498776 no 626 0.121664016341335 678 736008
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.16575648211529 0.16124804669983 no 627 0.121856458283257 643 390807
SGTC_1180 1193-0155 285 µM 1.16398475711209 0.161619310370878 no 628 0.122215094539959 611 2921347
SGTC_483 fpl-64176 144 µM 1.16215992861875 0.162002283892807 no 629 0.122585254102844 590 3423
SGTC_757 1066-0008 322 µM 1.16148477645757 0.162144126565663 no 630 0.122722405303743 684 6842497
SGTC_3346 9158254 43.5805 µM 1.15884749719203 0.162698967077877 no 631 0.123259176495738 648 17639500
SGTC_88 0180-0332 8.668 µM 1.15698284731074 0.163092003364486 no 632 0.123639684162525 653 3101745
SGTC_1838 st055369 84.5 µM 1.15554412613143 0.16339568258518 no 633 0.123933836797316 601 676036
SGTC_2867 9039098 71.43 µM 1.15337781151881 0.163853631610316 no 634 0.12437767235805 659 6463460
SGTC_3253 9135987 49.47 µM 1.14568066057926 0.165487504729352 no 635 0.125963654368626 591 4182430
SGTC_3023 9089636 49.47 µM 1.14379766938701 0.165888805958332 no 636 0.126353778309547 714 17249241
SGTC_451 chloral hydrate 100 µM 1.14320594581645 0.16601504327842 no 637 0.126476547103621 730 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_34 0469-0683 81.75 µM 1.14255996823237 0.166152925912297 no 638 0.126610667187768 668 3690923
SGTC_2692 st077426 47.7 µM 1.14110475316813 0.166463809636134 no 639 0.126913166771926 688 25238571
SGTC_887 0885-0007 9.62 µM 1.14069617450928 0.166551163493416 no 640 0.126998189531962 689 5719458
SGTC_3172 9105863 49.47 µM 1.14038607892287 0.166617481479197 no 641 0.127062745013334 592 2348785
SGTC_2011 4012611 177 µM 1.13978936766952 0.166745143907874 no 642 0.127187032185985 672 2049887
SGTC_3006 9075424 71.4286 µM 1.13846373596484 0.167028979832618 no 643 0.127463446594878 619 7465181
SGTC_1275 0867-0008 21.1 µM 1.1356610584305 0.16763009656761 no 644 0.128049222098526 677 3422836
SGTC_90 0870-0863 4.608 µM 1.13471774879961 0.167832730118869 no 645 0.128246799134104 720 1738164
SGTC_920 mycophenolic acid 780.421 nM 1.13233373557391 0.168345545642301 no 646 0.128747076064566 673 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2270 7924575 90.91 µM 1.12887799555027 0.169090683184384 no 647 0.129474652235654 704 1262135
SGTC_3115 9123671 49.47 µM 1.1283086259456 0.169213655375915 no 648 0.129594800898376 703 3286988
SGTC_331 k048-0133 24.5 µM 1.12786653185469 0.169309178248765 no 649 0.129688145068008 625 6813582
SGTC_2797 7859098 81.82 µM 1.12690380907334 0.169517312628339 no 650 0.129891576360022 678 972681
SGTC_1215 3852-0577 11.2 µM 1.12328275895865 0.170301629272354 no 651 0.130658711909702 758 2884876
SGTC_2430 5571206 200 µM 1.12149285695054 0.170690177829204 no 652 0.131039065172193 766 1731771
SGTC_3122 9126309 49.47 µM 1.12023675043227 0.17096318963154 no 653 0.131306443517913 669 17591206
SGTC_1456 k015-0012 13 µM 1.11938279817694 0.171148953576975 no 654 0.131488433163727 770 2989616
SGTC_2085 5307070 144.047 µM 1.11814819758353 0.171417749730832 no 655 0.131751852225213 627 2840351
SGTC_2642 cholecalciferol 100 µM 1.11487458573271 0.172131783053821 no 656 0.132452084379419 675 9821465 A vitamin D precursor, similar to steriods.
SGTC_1021 4476-0760 85.3 µM 1.11393072870899 0.172338007213244 no 657 0.1326544527253 676 746768
SGTC_557 1315-0110 16.2 µM 1.11280083207647 0.172585086523588 no 658 0.132896988986746 693 6833801
SGTC_1679 SEC14.276 6.7 µM 1.11216092376521 0.172725118134077 no 659 0.133034482882475 734 1005053 YMR079W SEC14
SGTC_3267 9137951 49.47 µM 1.11031167028121 0.173130198590433 no 660 0.133432372952363 652 16643986
SGTC_921 1561-0023 372 µM 1.10912359298806 0.173390766856454 no 661 0.133688434139662 704 24050882
SGTC_114 0364-0001 490.298 µM 1.10449859448304 0.174407494163104 no 662 0.134688456456387 707 4003655
SGTC_1199 1638-0010 4.46 µM 1.10177233411357 0.175008586723507 no 663 0.135280330429371 722 3111136
SGTC_1147 3809-1045 12.3 µM 1.09923763595736 0.175568620812876 no 664 0.135832213254634 689 325925
SGTC_949 1165-0505 146 µM 1.09740254068012 0.175974787682821 no 665 0.136232731638958 760 6244267
SGTC_3004 9076122 71.4286 µM 1.09705461256519 0.176051862649173 no 666 0.136308759668746 706 44782551
SGTC_2981 9013952 38.96 µM 1.09408806358481 0.176709896780072 no 667 0.136958178500898 644 2996344
SGTC_251 melphalan 456.522 µM 1.09136858713092 0.177314490055888 no 668 0.137555364481783 800 460612 A DNA alkylator.
SGTC_2025 5147754 141 µM 1.09100480030524 0.177395465982192 no 669 0.13763538517928 707 315777 YLR208W SEC13
SGTC_2132 5317594 122.667 µM 1.09005969085301 0.177605948593977 no 670 0.137843425503585 649 794577
SGTC_328 k915-0120 63.5 µM 1.0888601153726 0.17787332946811 no 671 0.138107788473427 711 6624543
SGTC_177 1327-0068 8.361 µM 1.08837546687162 0.177981427770437 no 672 0.138214693518257 724 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1128 3448-9350 235 µM 1.08681408420325 0.178329967603715 no 673 0.13855949102959 637 619386
SGTC_1755 st041960 45.185 µM 1.08621958555165 0.178462787611246 no 674 0.138690927090062 712 2257073
SGTC_1955 wogonin 32.4 µM 1.08469444817432 0.178803811318422 no 675 0.139028503803925 696 5281703 A flavanone.
SGTC_2470 5664817 21.68 µM 1.08257719417568 0.179277912984422 no 676 0.139498067260496 728 2859561
SGTC_2196 6573537 42.6665 µM 1.07962117017053 0.179941155462868 no 677 0.140155455130935 718 2903087
SGTC_1172 0370-0043 85 µM 1.07921425740806 0.180032574898624 no 678 0.140246112659725 715 376585
SGTC_2731 amoxapine 43.43 µM 1.07872968167085 0.180141480593902 no 679 0.140354124942748 629 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.07817924551071 0.180265238208165 no 680 0.140476886072939 796 4114 Related to psoralen; DNA damaging agent.
SGTC_1676 st018489 23.4 µM 1.07653168810367 0.180635986447488 no 681 0.14084476842617 724 3696235
SGTC_1459 k035-0031 35.7 µM 1.0745622439237 0.181079795471829 no 682 0.141285381670581 646 3877128 YMR208W ERG12
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.07018756429608 0.182068059402817 no 683 0.14226744538353 709 5355888
SGTC_1837 st055472 66.5 µM 1.06891630463014 0.182355875018352 no 684 0.142553692178174 747 676091
SGTC_2405 ticlatone 3.52 µM 1.06786021059121 0.182595192777464 no 685 0.142791786582341 689 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_729 4092-0585 94.1 µM 1.06625457091323 0.182959416729445 no 686 0.143154289764826 679 2169061
SGTC_2369 9071472 200 µM 1.06537366967603 0.183159433177695 no 687 0.143353433553164 750 17296037
SGTC_1590 st077108 57.8 µM 1.06499425918435 0.183245623706297 no 688 0.143439263822954 732 5489485
SGTC_1029 k015-0030 64.7 µM 1.06472031932507 0.183307870235542 no 689 0.14350125608271 719 2208316
SGTC_2593 nobiletin 86.24 µM 1.06401890360106 0.183467310908297 no 690 0.143660068047358 677 72344 An anti-infammatory.
SGTC_2627 acetyl isogambogic acid 100 µM 1.06379315021196 0.183518645894739 no 691 0.14371120751985 683 6857789 A caspase activator and apoptosis inducer.
SGTC_2567 aureobasidin a 60 nM 1.06242660662385 0.183829580913542 no 692 0.144021030180888 718 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1377 2944-0135 198 µM 1.06093298264276 0.184169806116051 no 693 0.144360179382549 753 1894137
SGTC_3157 9099274 49.47 µM 1.06031393330556 0.184310931101286 no 694 0.14450090125171 722 17217662
SGTC_3035 9091303 49.47 µM 1.05228769031311 0.186146765021942 no 695 0.146333788806505 755 25237002
SGTC_829 1635-0120 117 µM 1.05155653078047 0.186314563744488 no 696 0.146501530134865 787 285054
SGTC_2004 4023728 41.89 µM 1.04884544549247 0.186937566552665 no 697 0.147124628720433 759 360084 YDR527W RBA50
SGTC_109 0132-0036 33.701 µM 1.04684131536544 0.187398939869564 no 698 0.147586385823544 627 67274 A color developer.
SGTC_2408 sulbentine 18.36 µM 1.04148842963097 0.188634681010914 no 699 0.148824460186182 745 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1663 st014140 55.4 µM 1.04020717518156 0.188931208636261 no 700 0.149121829341505 864 4207120
SGTC_881 0833-0569 170 µM 1.04017977233076 0.188937553760893 no 701 0.149128193660838 753 5418700
SGTC_423 5-fluorouracil 457 µM 1.03980810892175 0.189023625314123 no 702 0.149214530501634 735 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_269 exalamide 29 µM 1.03961586198193 0.189068156237123 no 703 0.149259202266838 739 3316 A derivative of salicylamide.
SGTC_749 1000-0129 128 µM 1.03930336742856 0.18914055437917 no 704 0.149331834612971 805 708470
SGTC_1640 st009078 66.4 µM 1.03772269300371 0.189507023532184 no 705 0.149699588417231 692 690618
SGTC_237 nikkomycin 200 µM 1.03749704709743 0.189559373691965 no 706 0.149752135591833 786 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.03746849562724 0.189565998306292 no 707 0.149758785377651 734 75037 A free radical scavenger.
SGTC_2512 diallyl trisulfide 49.23 µM 1.03711523946851 0.189647973847953 no 708 0.149841076868778 726 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2285 7945142 200 µM 1.03486210859612 0.190171341431381 no 709 0.150366656252817 721 2970608
SGTC_2756 carbadox 75.1 µM 1.03224441374915 0.190780504855803 no 710 0.150978816870036 748 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2350 9023895 38.85 µM 1.03154129764393 0.190944330690966 no 711 0.151143526164827 754 2997209
SGTC_2670 beta-carotene 100 µM 1.03153711103912 0.190945306426964 no 712 0.151144507260792 703 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2885 9057732 51.95 µM 1.03122286055273 0.191018554817321 no 713 0.151218161339777 738 6471414
SGTC_1276 0871-0068 94.2 µM 1.03056704567648 0.191171473673562 no 714 0.151371948229957 761 3414906
SGTC_3148 9097893 49.47 µM 1.02922313214408 0.191485073527601 no 715 0.151687417320453 705 17174100
SGTC_773 4358-1457 44.6 µM 1.02698642981519 0.192007702394908 no 716 0.152213427015318 835 1186886
SGTC_2714 st079313 56.9 µM 1.02640984723956 0.192142568328852 no 717 0.152349219177736 759 2939799
SGTC_2664 lyso-paf C-16 73.48 µM 1.02376662394189 0.192761574765289 no 718 0.152972759188124 813 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1079 idarubicin 2.36 µM 1.02261355648751 0.193031988516729 no 719 0.153245298675378 756 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3219 9131112 49.47 µM 1.01891715614007 0.193900417012831 no 720 0.154121149058097 750 17612988 YMR079W SEC14
SGTC_1486 3970-0793 4.53 µM 1.0145467842343 0.194930254059467 no 721 0.155160958693826 800 2844330
SGTC_2971 9092186 9.93 µM 1.01314612308363 0.195261009184698 no 722 0.155495185160748 720 25236400
SGTC_1973 st070275 50.2 µM 1.0121948783995 0.195485832462103 no 723 0.155722442270155 768 17118334
SGTC_1770 st043884 66.3 µM 1.01096455159185 0.19577684885556 no 724 0.15601669817657 794 670149
SGTC_2771 fluoxetine 41.05 µM 1.00639713192447 0.196859505271785 no 725 0.157112286371018 763 3386 A selective serotonin reuptake inhibitor.
SGTC_2945 9067681 61.76 µM 0.996351046311992 0.199253540291543 no 726 0.159539804799029 778 16456930
SGTC_2238 6671620 73.2395 µM 0.993452776678919 0.199947458714521 no 727 0.160244676439603 771 729941
SGTC_1942 st076330 65.2 µM 0.992964108527829 0.200064601119263 no 728 0.160363722870535 783 24208414
SGTC_1357 1503-1303 39.5 µM 0.991871063448408 0.200326772676559 no 729 0.160630213175714 832 292895
SGTC_3103 9120822 49.47 µM 0.989815393605643 0.200820392697966 no 730 0.161132179655032 845 17141819
SGTC_2354 9060492 162 µM 0.988651956152891 0.201100087598356 no 731 0.16141672825284 873 6471895
SGTC_885 0865-0106 16.8 µM 0.987156518298675 0.201459939635486 no 732 0.161782957097122 803 2793380
SGTC_107 0358-0022 2.6945 µM 0.985096533227372 0.201956271891796 no 733 0.162288328047251 694 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1487 3970-0795 2.82 µM 0.984458412513678 0.202110168889536 no 734 0.162445084853969 839 3765103
SGTC_1603 st002045 67.8 µM 0.982339453867734 0.20262170605051 no 735 0.16296632182229 837 5887985
SGTC_1714 st033236 13.627 µM 0.981991285463309 0.202705831236747 no 736 0.163052070729617 828 2916566
SGTC_1779 st039427 55 µM 0.980399846512306 0.203090623738931 no 737 0.163444392748806 901 1124498
SGTC_847 0342-0274 5.54 µM 0.975443526483943 0.204291798555092 no 738 0.164670150892338 865 18097
SGTC_2262 9014885 67.46 µM 0.971402205079142 0.205274345059056 no 739 0.165674015452749 768 6457424
SGTC_1170 0310-0127 64.8 µM 0.970754929417322 0.205431974410029 no 740 0.165835165667234 857 774975
SGTC_2036 5160441 105 µM 0.969701558702435 0.205688652650931 no 741 0.166097636653496 887 134534 YIL048W NEO1
SGTC_1685 st024049 53.0905 µM 0.968813299044916 0.205905245603916 no 742 0.166319174976526 810 1941139
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.968015122077034 0.206099988185701 no 743 0.166518408726955 906 688788
SGTC_96 0929-0093 37.281 µM 0.963274912953609 0.207258772721752 no 744 0.167704789739254 807 6991579
SGTC_594 1487-1584 10.8 µM 0.961736810895816 0.207635601211008 no 745 0.168090913212719 843 5013332
SGTC_2288 7946289 167.31 µM 0.958337416178021 0.208469873148388 no 746 0.168946321145891 908 1246052
SGTC_496 calpeptin 138 µM 0.957652562324412 0.208638187386833 no 747 0.169118992435767 758 73364 A calpain inhibitor.
SGTC_2400 5203494 178.7 µM 0.956012287887715 0.209041637684868 no 748 0.169533013212837 777 6777674
SGTC_268 camptothecin 39.6153 µM 0.953733623014431 0.209602871579687 no 749 0.170109248023899 933 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2492 derrusnin 100 µM 0.952454130376985 0.209918398047373 no 750 0.170433359135159 776 1715307 Part of coumarin class of compounds.
SGTC_797 k781-0471 270 µM 0.952195413004197 0.209982232388852 no 751 0.170498943443962 863 23738129
SGTC_2959 9079155 11 µM 0.951694284608084 0.210105910183416 no 752 0.170626024397923 790 16189457
SGTC_1976 st070609 63.5 µM 0.95154842652094 0.210141915796222 no 753 0.170663023883442 871 682556
SGTC_2592 piperlongumine 83.33 µM 0.950895756129184 0.210303074305964 no 754 0.170828648183968 791 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_452 diindolylmethane 8 µM 0.947237243570769 0.211207783219473 no 755 0.171758950626078 793 3071 Inhibits expression of several cancer promoting factors.
SGTC_772 k072-0172 35.3 µM 0.945393701215628 0.211664533230143 no 756 0.172228958363965 787 5861980
SGTC_778 3456-2434 196 µM 0.943165436861634 0.21221737168216 no 757 0.17279814462975 960 5539063
SGTC_1832 st054113 55 µM 0.940484179382095 0.212883716569261 no 758 0.173484630484835 839 1251267
SGTC_3235 9132602 49.47 µM 0.937182301845807 0.21370597313941 no 759 0.174332395948894 886 4912240
SGTC_1505 k297-0037 20.6 µM 0.936069385894945 0.213983535537054 no 760 0.174618732052235 861 4089396
SGTC_916 4466-0038 42 nM 0.935498133810374 0.214126087866073 no 761 0.174765822315454 965 5722064 YGL116W CDC20
SGTC_1864 st057645 30.4 µM 0.935335496350842 0.214166683115067 no 762 0.174807713805581 864 688666
SGTC_2387 9077560 195.08 µM 0.93449486371306 0.214376581255524 no 763 0.175024342112757 850 5303272
SGTC_2413 inermin 26.06 µM 0.928307636802313 0.215925150814258 no 764 0.176624006904688 904 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_908 3448-7491 47.7 µM 0.928113136062021 0.21597393626359 no 765 0.176674443155316 934 1203031
SGTC_644 1498-1197 63.3 µM 0.927316103865274 0.216173917738461 no 766 0.176881217759317 925 6741615
SGTC_2160 5660466 132.927 µM 0.925068323713117 0.216738480256157 no 767 0.177465184387441 842 2859134
SGTC_1286 0929-0070 131 µM 0.918520256087805 0.218387973736486 no 768 0.179173279583006 913 1420408
SGTC_3136 9095672 49.47 µM 0.91789344893107 0.21854624814652 no 769 0.179337325846175 787 17217380
SGTC_744 1594-0068 283 µM 0.917105685861706 0.21874525899527 no 770 0.179543630938917 921 668392
SGTC_2712 st079126 47.7 µM 0.91670653772228 0.218846134706616 no 771 0.179648219656316 845 3152970
SGTC_433 pimozide 108 µM 0.91498873930486 0.219280574948239 no 772 0.180098770872737 772 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3088 9117578 49.47 µM 0.913540285986294 0.219647281281513 no 773 0.180479227903344 907 678341
SGTC_1917 st066507 28.5 µM 0.912897471699621 0.219810135951745 no 774 0.180648233691352 897 3156428
SGTC_1569 carminic acid 40.6 µM 0.911078329001128 0.220271384591735 no 775 0.181127051947878 928 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1140 3229-1848 2.98 µM 0.909850940626746 0.220582905570861 no 776 0.181450562731821 914 2849525
SGTC_669 0108-0021 26.2 µM 0.909535782123459 0.220662936026776 no 777 0.18153368944908 992 17201
SGTC_1559 coumarin 343 70.1 µM 0.907379101741964 0.22121104347714 no 778 0.182103178427212 868 108770 A hepatotoxic, DNA x-linker.
SGTC_1501 4491-0275 38.4 µM 0.907169643349085 0.221264317539011 no 779 0.18215854705736 931 5104718
SGTC_2051 5263410 176 µM 0.906896824713023 0.221333717773138 no 780 0.182230680232128 933 227584
SGTC_1224 0823-0416 294 µM 0.90519203501074 0.221767667946019 no 781 0.182681830391189 917 3598164
SGTC_288 1315-0019 35.1 µM 0.904714201251562 0.221889386547114 no 782 0.182808407829308 925 6811474
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.904652197148047 0.2219051836495 no 783 0.182824836634198 877 4330530
SGTC_2139 5578692 56.4705 µM 0.904352253843383 0.221981610806125 no 784 0.182904323579687 872 650991 YMR113W FOL3
SGTC_462 ag-879 158 µM 0.903807735763186 0.222120395323583 no 785 0.183048679554008 944 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2504 purpurogallin 52.29 µM 0.901447535391236 0.222722525694875 no 786 0.183675208450727 867 5281571 An antioxidant.
SGTC_2923 7992654 58.14 µM 0.899349047984241 0.223258668684522 no 787 0.184233384811974 896 2985126
SGTC_525 k781-2675 26.7 µM 0.899246063152787 0.223284999197058 no 788 0.184260804879312 917 3651118 YDL195W SEC31
SGTC_866 0495-0101 262 µM 0.898072801486063 0.223585096079133 no 789 0.184573369103879 857 635694
SGTC_1633 st005664 67.9 µM 0.897554445440815 0.223717754218082 no 790 0.184711567342425 931 2063822
SGTC_99 0109-0120 622.8 µM 0.89643470285819 0.224004472419298 no 791 0.185010319977784 886 759414
SGTC_1767 st044992 70.3 µM 0.895116045148775 0.224342391810707 no 792 0.185362528820748 908 9600693
SGTC_468 gf-109203x 121 µM 0.894367207503979 0.22453441779033 no 793 0.185562725918612 816 2396 A protein kinase C inhibitor.
SGTC_2739 tacrine 100.86 µM 0.894177390101702 0.224583107869286 no 794 0.185613493732236 882 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1516 st013856 110 µM 0.892572074093623 0.22499512708531 no 795 0.186043189802353 871 5281404 A mutagen and neurotoxin.
SGTC_1322 1348-1070 12 µM 0.892017529069144 0.225137555689511 no 796 0.186191768454119 913 6758089
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.890321597473692 0.22557345332718 no 797 0.18664661373975 922 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2328 6201408 200 µM 0.888657310934802 0.22600168131758 no 798 0.187093640072814 864 2890418
SGTC_1749 st037932 54.2 µM 0.887084322489376 0.2264068400238 no 799 0.187516751983723 859 594497
SGTC_3202 9113761 49.47 µM 0.884198287831289 0.227151269091011 no 800 0.188294591230817 987 4798415
SGTC_2458 5808907 16.39 µM 0.882667513316971 0.227546679191395 no 801 0.188707969758557 1001 2731747
SGTC_634 1611-4317 11.2 µM 0.88060044425313 0.228081232599784 no 802 0.18926705903208 982 2843522
SGTC_710 3448-4187 58 µM 0.878995188358318 0.228496845740313 no 803 0.189701942368344 996 3946412
SGTC_600 1495-0418 41.6 µM 0.877857269152964 0.228791719312509 no 804 0.190010590455048 905 5377768
SGTC_2377 9073351 62.6 µM 0.87708420938982 0.228992167188234 no 805 0.190220450398187 893 7337946 YHR072W ERG7
SGTC_2834 9001755 58.44 µM 0.875695190706313 0.229352575470613 no 806 0.19059788027275 860 2989575
SGTC_1744 st037937 38.9 µM 0.87344526421396 0.229937037361116 no 807 0.191210214159556 922 1016152
SGTC_3026 9090633 49.47 µM 0.873244673726427 0.229989185061645 no 808 0.191264864814742 967 25236842
SGTC_119 0121-0043 24.815 µM 0.872025777138821 0.230306205040551 no 809 0.191597157653896 1088 1092378
SGTC_2194 5927483 104.545 µM 0.871990221821988 0.230315456206799 no 810 0.191606855969249 1003 760979
SGTC_247 mechlorethamine 29.705 µM 0.871461475263168 0.230453055715953 no 811 0.191751116038727 903 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3196 9111891 49.47 µM 0.870439880955588 0.230719042651208 no 812 0.192030030082379 956 18891510
SGTC_3301 9125354 19.7965 µM 0.86722326558999 0.23155765431483 no 813 0.192909845529923 874 41905162
SGTC_266 formosanin C 406 nM 0.866519067728661 0.231741473908668 no 814 0.193102787220436 960 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1611 st001856 99.4 µM 0.865384340922438 0.232037847184689 no 815 0.193413936401126 909 647478
SGTC_2484 5809818 12.04 µM 0.864154127019221 0.232359398494079 no 816 0.193751614096032 917 2870548
SGTC_1223 0764-0573 147 µM 0.862396169324104 0.232819320498748 no 817 0.194234773900484 1008 1609797
SGTC_2778 tioconazole 65.09 nM 0.861599224709972 0.233027985975207 no 818 0.194454048895828 909 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2546 rhodinyl acetate 100 µM 0.861005070014298 0.233183622146356 no 819 0.19461762534897 980 6708682
SGTC_1888 azatryptophan 97.5 µM 0.85627635801347 0.234424342016589 no 820 0.195922467589887 873 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2263 7948595 193.29 µM 0.854283938785989 0.23494820490846 no 821 0.196473842076778 893 2971371
SGTC_3201 9113999 49.47 µM 0.854110583455525 0.234993815456444 no 822 0.196521860195228 905 16649224
SGTC_1080 nisoldipine 24.4 µM 0.853270943744749 0.235214797562573 no 823 0.196754534672387 970 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2570 licareol 100 µM 0.852710304459206 0.235362414299246 no 824 0.196909987554187 895 443158
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.851880001325479 0.235581127639658 no 825 0.197140348820698 992 688751
SGTC_529 4076-0302 30.3 µM 0.851460900221456 0.235691567238028 no 826 0.197256687126468 919 5816522
SGTC_3069 9117009 49.47 µM 0.851141459526285 0.235775763955244 no 827 0.197345388578131 850 41904981
SGTC_1213 1315-0166 115 µM 0.849636059391257 0.236172773586182 no 828 0.197763728759196 846 768401
SGTC_695 3505-6186 243 µM 0.849368598377995 0.2362433478848 no 829 0.197838110327513 969 1819379
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.845784837077961 0.237190105945433 no 830 0.198836392865259 1010 23847180
SGTC_835 0312-0010 67.2 µM 0.844064707520136 0.237645269009999 no 831 0.199316623936934 939 1626196
SGTC_3268 9137683 49.47 µM 0.84404286209193 0.237651052603662 no 832 0.19932272729874 955 1953228
SGTC_1553 gossypol 38.6 µM 0.844020904413907 0.237656865993373 no 833 0.199328862135263 915 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1056 3448-1962 115 µM 0.841973886204688 0.238199165422014 no 834 0.199901285343995 932 715507
SGTC_1060 3448-7350 82 µM 0.841225721715779 0.238397539438438 no 835 0.200110746687348 959 570178
SGTC_1470 k295-0292 231 µM 0.839692324337649 0.238804398637111 no 836 0.200540459373928 1013 5045612
SGTC_1414 3917-0015 5.4 µM 0.836269143049983 0.239714046589113 no 837 0.201501754115694 998 6618702
SGTC_2225 6654152 15.4 µM 0.835530741414692 0.239910510975131 no 838 0.201709472865657 942 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2846 9008642 19.48 µM 0.83459308669284 0.240160116565664 no 839 0.20197342797186 948 2992898
SGTC_442 cape 100 µM 0.834379266956337 0.24021705562603 no 840 0.202033648372973 958 5281787
SGTC_78 0336-0123 156.75 µM 0.831535510872001 0.240975031890655 no 841 0.20283558804249 903 6765896
SGTC_1743 st037606 46.3785 µM 0.831233596413102 0.241055580641764 no 842 0.202920839486638 971 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.829887455882868 0.241414899992601 no 843 0.203301208914922 1000 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1274 0865-0114 173 µM 0.827003937370274 0.242185563016222 no 844 0.204117414899517 1000 870624
SGTC_2921 7974240 10.71 µM 0.826537956921698 0.242310228247321 no 845 0.204249497837299 975 2979074 YDR527W RBA50
SGTC_761 k216-0224 480 µM 0.824609671848238 0.242826477990272 no 846 0.204796614293664 1064 1340404
SGTC_1794 st048918 76.9 µM 0.824290233271378 0.242912057053519 no 847 0.20488733336569 948 672303
SGTC_1314 1222-0010 41.1 µM 0.824066569474241 0.242971987324403 no 848 0.204950867065209 999 3526027
SGTC_1390 3413-2614 145 µM 0.823761230260347 0.243053815272482 no 849 0.205037620303198 1062 3421432
SGTC_1228 0124-0032 52.5 µM 0.821800929399476 0.243579511715685 no 850 0.205595102351967 1048 X1228
SGTC_625 k213-0058 121 µM 0.821038545568364 0.243784126910224 no 851 0.205812156404077 1132 3655420
SGTC_3197 9113331 49.47 µM 0.819454591335319 0.244209538758475 no 852 0.20626354964683 1002 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2803 7707263 71.43 µM 0.818836740458103 0.244375587025806 no 853 0.206439782963483 965 2199229
SGTC_2984 9022109 38.96 µM 0.818618737502274 0.244434190136305 no 854 0.206501986542117 993 6459207
SGTC_3078 9116413 49.47 µM 0.818131059716996 0.244565314097106 no 855 0.20664117761829 1004 17177322
SGTC_1686 st019653 115.5 µM 0.816308362637216 0.245055725508734 no 856 0.207161896326111 1032 97252
SGTC_325 2810-4341 181 µM 0.813143213196888 0.245908589924542 no 857 0.208067976524843 1046 774970
SGTC_2496 diffractaic acid 79.83 µM 0.812091900067362 0.24619222320847 no 858 0.208369450310457 1022 94870 An apoptosis inducer which activates caspases.
SGTC_458 nppb 133 µM 0.809882538367443 0.246788857149972 no 859 0.209003844297145 1013 4549 A chloride channel blocker.
SGTC_1058 3448-5425 97.3 µM 0.808512902529276 0.247159113032252 no 860 0.209397690756531 1003 7279705
SGTC_803 4488-1585 147 µM 0.808247708266723 0.247230837743656 no 861 0.209473999286743 1002 747204
SGTC_2162 5663267 200 µM 0.80620155352356 0.247784616871966 no 862 0.210063321555343 1059 6456493
SGTC_3203 9113543 49.47 µM 0.801294594526976 0.249115348898403 no 863 0.211480559728648 1009 17018012
SGTC_3089 9117425 49.47 µM 0.800812790857685 0.249246215246975 no 864 0.21162001649854 1009 9401657
SGTC_2451 5856223 45.7 µM 0.800733049778857 0.24926787785139 no 865 0.211643102529239 1015 2179896
SGTC_2122 5258151 111.688 µM 0.800631156002355 0.249295559954179 no 866 0.211672604185774 1005 2173356
SGTC_2591 skatole 100 µM 0.800404730960201 0.249357080075386 no 867 0.211738170425656 1025 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1001 4048-4355 44.4 µM 0.797335232585344 0.250191864362748 no 868 0.212628181701638 1013 21824233
SGTC_1202 1988-0068 29.6 µM 0.796072499064825 0.25053570859443 no 869 0.212994948796763 1026 2850480
SGTC_1260 0700-1617 7.75 µM 0.795261384889899 0.250756708198122 no 870 0.213230735440122 1023 2853078
SGTC_2187 6125751 200 µM 0.791728178644914 0.251720583437258 no 871 0.214259594040907 1028 874498
SGTC_924 2046-0044 21.3 µM 0.791257794735804 0.25184905379264 no 872 0.214396785858988 1097 3623589
SGTC_2019 4016004 108 µM 0.788496752576419 0.252603841664056 no 873 0.215203098673893 1033 45595336
SGTC_1920 st075728 45.7 µM 0.78811241896131 0.252709001590269 no 874 0.215315475795155 1033 3400306
SGTC_1527 coumarin 137 µM 0.786984115231049 0.253017856975169 no 875 0.215645582506657 1011 323 A hepatotoxic, DNA x-linker.
SGTC_869 0564-0080 44.1 µM 0.786819675419726 0.253062886361302 no 876 0.215693716987829 1013 6843321
SGTC_1696 st025591 34.7925 µM 0.785023683337476 0.253554966315918 no 877 0.21621984145411 1077 2787147
SGTC_1427 4048-4900 550 nM 0.780654665977694 0.254754119427909 no 878 0.217502815293885 1078 24132586
SGTC_2440 5628896 157.78 µM 0.780531372315946 0.254788002552762 no 879 0.21753908445193 1051 5522048
SGTC_282 k297-0036 65.7 µM 0.778745077232919 0.255279170379518 no 880 0.218064948387547 1046 5061378
SGTC_2022 5136654 200 µM 0.777479276235282 0.255627520204824 no 881 0.218438028270883 1050 1713771
SGTC_1026 k007-1105 30.6 µM 0.772980299705061 0.256867649833407 no 882 0.219767019860528 1072 7066794
SGTC_373 0844-0104 25.9 µM 0.772184112692247 0.257087442046136 no 883 0.220002694904168 1130 5375804
SGTC_1583 clindamycin 39.6 µM 0.771098577756943 0.257387268002046 no 884 0.220324251780243 993 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2156 5649887 115 µM 0.770706941454735 0.257495482967366 no 885 0.220440328289987 1135 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1241 0364-0022 50.8 µM 0.77038662959859 0.257584007488323 no 886 0.220535291101993 1064 4563895
SGTC_1641 st009299 47.1 µM 0.770136382903289 0.257653179111107 no 887 0.220609498012863 1038 4046054
SGTC_1277 0873-0036 22 µM 0.76678812779355 0.258579609766814 no 888 0.221603748111145 1121 5965735
SGTC_3025 9087895 49.47 µM 0.765119111458639 0.259042054251743 no 889 0.222100310263174 1123 17173641
SGTC_1719 st032227 49.2 µM 0.763460218522091 0.259502117222377 no 890 0.222594489276294 1132 3125804
SGTC_2734 clemastine 41.6 µM 0.762320913889843 0.259818326322137 no 891 0.222934247351133 1033 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2273 7815444 169.05 µM 0.762188677008127 0.259855040972023 no 892 0.222973701537212 1074 2824616
SGTC_1860 st056228 74.6 µM 0.761675807457604 0.259997460950031 no 893 0.223126758876332 1097 688679
SGTC_524 r073-0010 27.8 µM 0.759521488647087 0.260596138273324 no 894 0.223770332279353 1027 2772106
SGTC_652 0437-0092 114 µM 0.759278106297957 0.260663817925429 no 895 0.223843105722704 1087 3091274
SGTC_619 1652-1634 108 µM 0.759113855113395 0.260709497931784 no 896 0.223892225859415 1035 5400454
SGTC_1006 4099-6547 255 µM 0.759066600672709 0.260722640658797 no 897 0.223906358670368 1094 3146833
SGTC_2532 xanthone 78.9 µM 0.759051526639149 0.260726833223443 no 898 0.223910867103929 1000 7020 An insecticide.
SGTC_1773 st048542 73.5835 µM 0.755098154112782 0.261827587358271 no 899 0.225095045326129 1053 3237138
SGTC_3018 9082602 49.47 µM 0.754597574223275 0.26196713574688 no 900 0.22524523981079 1117 17332089
SGTC_2563 tomatine 8.54 µM 0.753343887063353 0.262316797723394 no 901 0.225621646328519 1103 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2326 6164455 177.58 µM 0.752920565197215 0.262434919066063 no 902 0.22574882464788 1063 2888790
SGTC_3005 9076496 71.4286 µM 0.751574265734465 0.26281076380878 no 903 0.226153561988851 1086 21368410
SGTC_527 4476-4215 268 µM 0.751063594366557 0.262953399276684 no 904 0.226307192073081 1066 4418754
SGTC_1480 1070-0044 41.2 µM 0.751046697282618 0.262958119472459 no 905 0.226312276389603 1112 3124987
SGTC_1002 4049-0206 172 µM 0.746092180819493 0.264344028145457 no 906 0.227805866201367 1163 4662749
SGTC_1145 3546-0597 10.2 µM 0.743429814207831 0.26509029516561 no 907 0.228610749723075 1086 875334
SGTC_3155 9099265 49.47 µM 0.741159604542416 0.26572748398896 no 908 0.229298336554913 1040 25236499
SGTC_2170 morpholine 200 µM 0.74060608801096 0.265882959343325 no 909 0.22946615779804 1119 121171 Reacts with secondary amines.
SGTC_805 3852-0218 479 µM 0.739736837839329 0.266127213036536 no 910 0.229729845517888 1096 6615355
SGTC_3244 9134489 49.47 µM 0.737909265317696 0.266641119428743 no 911 0.230284794134722 1120 16584271
SGTC_2080 5212524 12.4 µM 0.737489586897904 0.26675920218965 no 912 0.230412336679396 1095 260183
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.737032378339347 0.266887874685772 no 913 0.230551329771641 1097 17037758
SGTC_2043 5101342 149 µM 0.737017935610728 0.266891939822927 no 914 0.230555721177882 1136 678451
SGTC_1727 st034309 9.9045 µM 0.735071664948632 0.26744003483129 no 915 0.231147924934958 1170 870305
SGTC_1704 st028805 70.8 µM 0.734898089217568 0.267488943561512 no 916 0.23120078108513 1122 2876101
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.733575392244637 0.267861790228022 no 917 0.231603781555837 1133 7104
SGTC_2127 5253358 187.912 µM 0.729697880327004 0.268956303883399 no 918 0.232787438535655 1096 20612
SGTC_1451 4152-0210 104 µM 0.729353749528397 0.269053550789834 no 919 0.232892650741716 1138 659563
SGTC_646 4092-0839 27.3 µM 0.728500607001885 0.269294713895868 no 920 0.23315359861262 1172 877796
SGTC_2687 chenodiol 100 µM 0.727112478366899 0.269687336403912 no 921 0.233578527597484 1124 5702181 A cholesterol synthesis inhibitor.
SGTC_2164 5685496 200 µM 0.726096491231143 0.269974882899548 no 922 0.233889809946272 1142 759046
SGTC_2282 7944268 200 µM 0.722936355591626 0.270870249827537 no 923 0.234859493199179 1165 2970414
SGTC_2493 resveratrol 26.09 µM 0.719569696312563 0.2718257590788 no 924 0.23589498783061 1091 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_71 0417-1750 47.813 µM 0.719134957588558 0.271949266720046 no 925 0.236028885091221 1148 6811472
SGTC_2957 9076800 11.52 µM 0.719096107893158 0.27196030513131 no 926 0.236040852632941 1110 16459615
SGTC_839 0122-0028 230 µM 0.719024432392988 0.271980670963286 no 927 0.23606293295088 1149 759448
SGTC_336 4111-0029 111 µM 0.718063767059314 0.272253707003041 no 928 0.236358984839067 1118 3131175
SGTC_2210 7115885 190.385 µM 0.71791580226736 0.272295773001663 no 929 0.236404601871003 1171 2927039
SGTC_319 1348-1596 45.5 µM 0.713965727923015 0.273419961102831 no 930 0.23762418604594 1186 5380505
SGTC_725 1497-0963 19 µM 0.71384825819193 0.273453428050024 no 931 0.237660507571704 1186 3549977
SGTC_1301 naphtanilide LB 4.81 µM 0.712825093815152 0.273745011748772 no 932 0.237976997770255 1214 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1807 st050092 58.9 µM 0.712747327872294 0.2737671799498 no 933 0.238001062155537 1149 5008496
SGTC_886 0866-0150 153 µM 0.712625386059555 0.273801942848961 no 934 0.238038799287068 1193 271463
SGTC_2776 terbinafine 19.92 µM 0.712249980729182 0.273908976263098 no 935 0.238154995942457 1189 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1771 st048882 4.1505 µM 0.710912382778558 0.274290512582977 no 936 0.238569266073332 1157 4580403
SGTC_2120 5538279 151.968 µM 0.710257619137942 0.274477372922451 no 937 0.238772197932313 1169 2058197
SGTC_780 0109-0199 192 µM 0.709743865662178 0.274624034911424 no 938 0.238931492396509 1206 610414
SGTC_813 k007-0158 173 µM 0.709432064291424 0.27471306416896 no 939 0.239028197896495 1196 6523916
SGTC_737 1950-0117 57.9 µM 0.709278788195927 0.274756834610476 no 940 0.239075744471014 1149 5393513
SGTC_720 r052-1644 49.9 µM 0.70789307239972 0.275152703915214 no 941 0.239505831044509 1155 1422863 YOR257W CDC31
SGTC_2226 7298446 200 µM 0.707662503981918 0.275218599614081 no 942 0.239577433860937 1168 3283010
SGTC_3256 9138902 49.47 µM 0.707639153461468 0.275225273549598 no 943 0.23958468599582 1204 17228773
SGTC_2589 lobaric acid 100 µM 0.707088601326868 0.275382652842498 no 944 0.239755709549653 1180 73157 A novel microtubule depolymerizer.
SGTC_2183 6420625 130.508 µM 0.706069488557285 0.275674090365007 no 945 0.240072462510189 1207 2897619
SGTC_817 1391-0715 46 µM 0.704802617508552 0.276036591036665 no 946 0.240466539706187 1144 1353946
SGTC_1836 st055642 81 µM 0.699874148864016 0.277449038442029 no 947 0.242002951466223 1173 8571
SGTC_2724 maprotiline 69.64 µM 0.698563930682932 0.277825126792094 no 948 0.242412295823125 1171 4011 A tricyclic antidepressant.
SGTC_1341 1486-1360 280 µM 0.696181800510731 0.278509536452035 no 949 0.243157491833694 1193 3976547
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.696024221108995 0.278554839526562 no 950 0.243206830655645 1207 3256 An antibiotic and ribosome inhibitor.
SGTC_93 0109-0045 59.227 µM 0.695664648261562 0.278658227868212 no 951 0.243319434799595 1274 88733
SGTC_3347 9188721 44.724 µM 0.695146246890084 0.278807317214396 no 952 0.243481827403362 1187 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2974 9094440 9.66 µM 0.691135574279484 0.279962074478477 no 953 0.244740173098809 1214 25236134
SGTC_1961 st076550 68.7 µM 0.690498215717772 0.280145796775864 no 954 0.244940465810526 1175 1579337
SGTC_1929 genistein trimethyl ether 50.5 µM 0.688468413593844 0.280731287991655 no 955 0.245578927292295 1231 136420
SGTC_2356 9061756 188.97 µM 0.687459484391801 0.281022531059003 no 956 0.245896611902344 1178 20104043
SGTC_1907 st060210 83.7 µM 0.686839997248531 0.281201427944818 no 957 0.246091780936063 1236 688793
SGTC_2029 5175081 200 µM 0.685424488264597 0.281610408078239 no 958 0.246538047810702 1220 1380876
SGTC_1076 itraconazole 331 nM 0.684868287053099 0.281771188629178 no 959 0.246713519689213 1230 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1778 st046819 58.9 µM 0.682059016019215 0.282583937311143 no 960 0.247600817183807 1256 671715
SGTC_2545 solidagenone 89.61 µM 0.681318938824349 0.282798236037814 no 961 0.24783485109436 1061 6708572 An anti ulcer agent
SGTC_2418 pentamidine 31.67 µM 0.678454404685026 0.283628433233925 no 962 0.248741812004827 1211 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2243 6634756 200 µM 0.677947040184939 0.283775598862689 no 963 0.248902636395963 1263 885676
SGTC_1502 4534-4282 27.7 µM 0.677816261991273 0.283813538177841 no 964 0.248944099435217 1209 3278949
SGTC_161 4065-0411 162.148 µM 0.676345084129816 0.284240500414812 no 965 0.249410787427792 1225 1906281 YLR208W SEC13
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.67132793468246 0.285698871952853 no 966 0.251005821354607 1233 4174840
SGTC_655 k060-0012 42 µM 0.670891308649277 0.285825957427244 no 967 0.251144886774581 1195 5994525
SGTC_1730 st033808 45.1 µM 0.67012265834684 0.286049748018786 no 968 0.251389800931349 1226 1045166
SGTC_2644 guaiazulene 100 µM 0.669871047613771 0.286123021931346 no 969 0.251469998785397 1246 3515 A coloring agent.
SGTC_1519 esterone 74 µM 0.668863839212232 0.286416429756199 no 970 0.251791169524902 1208 698 A steroid.
SGTC_1247 0448-0043 5.84 µM 0.668312853814778 0.286576996588971 no 971 0.251966955038331 1269 3089013 YGL099W LSG1
SGTC_620 0109-0052 432 µM 0.667258172547565 0.286884468286782 no 972 0.252303619435206 1244 493037
SGTC_190 3970-0790 3.722 µM 0.666033589184079 0.287241667613033 no 973 0.252694815555448 1218 2832352
SGTC_2962 9082311 13.18 µM 0.664329382352799 0.287739118547857 no 974 0.253239759684934 1232 16459453
SGTC_1167 k781-0610 148 µM 0.661151135482411 0.28866792150552 no 975 0.254257697317447 1278 4525169
SGTC_1344 1488-0097 29.1 µM 0.6577138472237 0.289674012585633 no 976 0.255361011393546 1251 747966
SGTC_2044 5102272 200 µM 0.655702288913092 0.290263556213424 no 977 0.256007847925492 1237 592666
SGTC_2292 7671323 168.05 µM 0.655691704714202 0.290266659695799 no 978 0.256011253638811 1250 937504
SGTC_1967 st070177 51.4 µM 0.653791286163612 0.290824149234365 no 979 0.256623140622679 1318 5729214
SGTC_466 geldanamycin 89.2 µM 0.653688761086289 0.290854239285844 no 980 0.256656172757918 1170 5288382 HSP90 inhibitor.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.651086349740442 0.291618506967169 no 981 0.257495373782842 1243 689007
SGTC_830 4076-0286 57.8 µM 0.650833982414031 0.291692671152406 no 982 0.257576830562368 1314 6866659
SGTC_939 1165-0479 45.3 µM 0.650750833885751 0.291717108264777 no 983 0.257603671401968 1218 1377347
SGTC_521 r062-0005 13.8 µM 0.649691771552695 0.292028447063386 no 984 0.25794567004617 1196 2832033
SGTC_2655 perillic acid 100 µM 0.648015548159087 0.292521532259005 no 985 0.258487447017618 1251 5702197 An apoptosis inducer.
SGTC_531 3788-1495 174 µM 0.644065461451902 0.293685034620204 no 986 0.259766492970796 1256 2896655
SGTC_220 paclitaxel 373.376 µM 0.644010380679021 0.293701273853923 no 987 0.259784351295162 1255 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_156 3474-0145 5.642 µM 0.642521501828492 0.294140391128724 no 988 0.260267316467194 1220 2265471
SGTC_1446 4239-0190 62 µM 0.641748068354557 0.294368620694891 no 989 0.260518386664558 1278 1340085
SGTC_1694 st024011 44.9 µM 0.64026955199951 0.294805137908414 no 990 0.260998686068148 1332 2787533
SGTC_602 3130-1533 38.1 µM 0.639349526074216 0.295076916925296 no 991 0.261297788223626 1317 720941
SGTC_3024 9090631 49.47 µM 0.638516775448591 0.29532301394987 no 992 0.261568668758368 1236 25236383
SGTC_1256 0570-0116 285 µM 0.637864888434363 0.295515727485341 no 993 0.261780817776437 1262 410638
SGTC_2026 5148700 152 µM 0.633391670682092 0.296839675707238 no 994 0.263238951461019 1270 79838
SGTC_791 1348-1292 225 µM 0.632636146224267 0.297063557674109 no 995 0.263485638455111 1300 5437054
SGTC_1008 4106-0037 6 µM 0.631407296044506 0.297427863468604 no 996 0.263887123345176 1277 2905394
SGTC_1142 3253-1408 9.78 µM 0.631284234586209 0.297464357593074 no 997 0.263927346652841 1282 256655
SGTC_411 enrofloxacin 100 µM 0.630705776173633 0.297635927995373 no 998 0.264116460796161 1389 71188 A bacterial gyrase inhibitor.
SGTC_1400 3771-8998 51.5 µM 0.630002536410798 0.297844569271136 no 999 0.264346462372725 1256 670767
SGTC_27 0485-0001 32.618 µM 0.628924285498261 0.29816460050559 no 1000 0.264699313004001 1242 2054479
SGTC_1631 benzylvanillin 81.9 µM 0.628572105084365 0.298269163655587 no 1001 0.264814613635112 1314 75506
SGTC_1618 st003135 44.5 µM 0.626386922950238 0.298918321961041 no 1002 0.265530592420054 1252 1270615
SGTC_611 3453-1652 23.7 µM 0.626194977773776 0.298975374314329 no 1003 0.265593530480837 1306 1560575
SGTC_2566 crystal violet carbinol 226 nM 0.625436189159349 0.299200959386973 no 1004 0.265842408305784 1238 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_662 k832-1615 104 µM 0.624073639207486 0.299606234245046 no 1005 0.266289612480047 1322 5878478
SGTC_1688 st021091 57.6 µM 0.623785510852505 0.299691966571304 no 1006 0.266384228183929 1304 3656366
SGTC_1785 bathophenanthroline 24 µM 0.621605198483023 0.30034107639104 no 1007 0.267100750954779 1282 72812 An iron chelator.
SGTC_1912 st060209 90.8 µM 0.621603951073974 0.300341447944143 no 1008 0.267101161172999 1277 688787
SGTC_1356 1502-0781 85.8 µM 0.619260122813485 0.301039946861804 no 1009 0.267872505020444 1283 567702
SGTC_2705 st078069 42.8 µM 0.614723235415076 0.302394089024117 no 1010 0.269368756177889 1293 1530061
SGTC_2762 leflunomide 42.06 µM 0.613887605979715 0.302643800174584 no 1011 0.269644800414213 1333 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1464 k208-0027 110 µM 0.613646410204964 0.302715893889626 no 1012 0.269724504069057 1400 X1464
SGTC_3108 9121785 49.47 µM 0.609698830538243 0.303896921863088 no 1013 0.271030664691883 1310 17140271
SGTC_1251 0490-5699 265 µM 0.604442936896998 0.305472549098057 no 1014 0.272774598300542 1367 3883818
SGTC_3271 9137798 49.47 µM 0.602856295113265 0.305948907968489 no 1015 0.273302146348082 1290 6498326
SGTC_116 0155-0182 31.788 µM 0.601910383418682 0.306233056196086 no 1016 0.273616896078969 1316 771486
SGTC_703 3875-0075 71.8 µM 0.599898417148559 0.306837830707521 no 1017 0.274286968686939 1395 2850814
SGTC_417 st075190 100 µM 0.598083317165679 0.30738388093808 no 1018 0.274892170623315 1397 222757
SGTC_2725 haloperidol 53.21 µM 0.598051117642929 0.307393571623607 no 1019 0.274902912726525 1306 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2933 9026794 32.47 µM 0.598023714697563 0.307401818849449 no 1020 0.274912054803446 1379 17586027
SGTC_3117 9124945 49.47 µM 0.597689103000201 0.307502531871519 no 1021 0.275023698896189 1255 17592065
SGTC_1825 st052143 62.6 µM 0.59464006544343 0.308420913603851 no 1022 0.276042046275569 1390 674173
SGTC_980 1473-0395 201 µM 0.591715045448204 0.309303068974079 no 1023 0.277020709932008 1300 768876
SGTC_47 0149-0135 24.25 µM 0.590528974520807 0.309661089383006 no 1024 0.277418033187509 1271 5239155
SGTC_2629 bisabolol 100 µM 0.589411262856884 0.309998640631579 no 1025 0.277792711483105 1402 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2543 pimpinellin 60.67 µM 0.589018611327905 0.310117260251798 no 1026 0.27792439439701 1304 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3308 9128332 17.569 µM 0.588808910184048 0.310180618846605 no 1027 0.277994734011715 1423 17332805 YDL196W YDL196W
SGTC_1304 1165-0502 251 µM 0.585392095010809 0.311213759947568 no 1028 0.279142051420329 1376 767425
SGTC_3307 9126885 69.2785 µM 0.583822796255619 0.311688767746012 no 1029 0.279669769717015 1325 24824909
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.58380430258926 0.31169436742618 no 1030 0.279675991587925 1392 5393153
SGTC_2780 5215298 71.43 µM 0.582218563760113 0.312174673642738 no 1031 0.280209735387629 1369 2834131
SGTC_1418 3966-3099 2.4 µM 0.580935938143064 0.312563403286901 no 1032 0.28064181501388 1405 740335
SGTC_1468 k284-1086 134 µM 0.58064986054668 0.312650134253293 no 1033 0.280738230261421 1373 15996457
SGTC_289 k017-0060 526 µM 0.573808916188537 0.314727204518371 no 1034 0.283048557253036 1370 5512909
SGTC_1161 k007-0610 110 µM 0.572159504614216 0.315228885962937 no 1035 0.283606959636398 1429 5843850
SGTC_1399 3562-5772 25 µM 0.571700683031234 0.31536850078935 no 1036 0.283762385813128 1334 23847490
SGTC_2636 apigenin dimethyl ether 100 µM 0.570211182905136 0.3158219224628 no 1037 0.284267236099456 1391 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_900 1112-0045 141 µM 0.566408513355234 0.316980757011408 no 1038 0.285558054389139 1314 56211 YIL048W NEO1
SGTC_1057 3448-5381 134 µM 0.566220124023734 0.317038214046227 no 1039 0.28562207571508 1437 5497911
SGTC_2522 biochanin a 4.94 µM 0.565867686693707 0.317145716076593 no 1040 0.2857418646635 1403 5280373 A possible chelator.
SGTC_2800 7887935 81.82 µM 0.564203379991153 0.317653578833895 no 1041 0.286307863901603 1426 2961002
SGTC_1813 st051246 8.6015 µM 0.561445324386058 0.318495954371156 no 1042 0.28724699665259 1384 5291959
SGTC_2844 9010103 25.97 µM 0.561098921584024 0.318601820465269 no 1043 0.287365051642373 1390 2480525
SGTC_2361 9034121 116 µM 0.559557676309835 0.319073028470561 no 1044 0.287890590160586 1399 6496917
SGTC_309 k408-0051 1.48 µM 0.558990916779675 0.319246378597049 no 1045 0.28808395962705 1372 3640463
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.558139598642948 0.31950683861563 no 1046 0.288374531155087 1286 4000243
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.558001470329244 0.319549107250473 no 1047 0.288421690074779 1373 803109
SGTC_2457 5731572 11.68 µM 0.557875846828343 0.319587551324203 no 1048 0.288464582834413 1493 2865357
SGTC_2476 5806916 10.51 µM 0.556360431076268 0.320051460803742 no 1049 0.288982241560165 1377 2870194
SGTC_987 1497-1013 404 µM 0.555670419815118 0.320262785105196 no 1050 0.289218090801828 1392 1676435
SGTC_2646 retinol 96.75 µM 0.555549717348874 0.320299757690404 no 1051 0.289259356795085 1402 445354 A vitamin A analog and teratogen.
SGTC_3277 9138724 49.47 µM 0.554876952759439 0.320505866071723 no 1052 0.289489413542338 1363 15943418
SGTC_2008 4012253 172 µM 0.554231359683057 0.320703702239216 no 1053 0.289710259556742 1403 603940
SGTC_2167 5876490 200 µM 0.553864581882323 0.320816120677214 no 1054 0.289835762988521 1599 686534
SGTC_2827 7993847 71.43 µM 0.553841604010122 0.320823164007402 no 1055 0.289843626368346 1409 2985692
SGTC_3211 9128781 49.47 µM 0.552929356966752 0.321102844121112 no 1056 0.290155892100836 1398 17194361
SGTC_1853 st056710 91.2 µM 0.552658198685865 0.321185996420379 no 1057 0.290248741024633 1565 269167
SGTC_3129 9127257 49.47 µM 0.551111860034032 0.321660361611912 no 1058 0.290778497865365 1304 837894
SGTC_2649 anisomycin 9.56 µM 0.551021661173334 0.321688040604142 no 1059 0.290809412849053 1378 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2700 st077718 96.8 µM 0.549115860887837 0.322273097695014 no 1060 0.291462970558247 1407 904970
SGTC_3171 9103192 49.47 µM 0.54849493514313 0.322463809435246 no 1061 0.29167605302831 1446 13018434
SGTC_2581 avocatin a 64 µM 0.548348303945205 0.322508852706901 no 1062 0.291726382906797 1428 6710728 A skin care supplement.
SGTC_2704 st078022 71.1 µM 0.545344178611801 0.32343225515769 no 1063 0.292758412407512 1505 54697681
SGTC_1928 4'-methoxychalcone 40.3 µM 0.544694965818521 0.323631952213625 no 1064 0.292981663883046 1559 641818
SGTC_3144 9087057 49.47 µM 0.542617073845187 0.324271450478888 no 1065 0.293696740426353 1405 17249618
SGTC_1879 gemcitabine 100 µM 0.542544447007826 0.324293811724854 no 1066 0.293721748508037 1425 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2163 5671233 125 µM 0.542523585870352 0.324300234826177 no 1067 0.293728931944355 1536 701023
SGTC_1983 st071813 46.9 µM 0.541515192273035 0.324610779456535 no 1068 0.294076264527487 1413 11838595
SGTC_2893 9048488 25.97 µM 0.539633495100305 0.325190592473877 no 1069 0.294724906206575 1356 6467338
SGTC_879 0831-1030 162 µM 0.538419857195867 0.325564779138927 no 1070 0.295143610197657 1423 1549252
SGTC_1392 3455-1037 33.9 µM 0.538328172745483 0.325593054273487 no 1071 0.295175252375451 1460 981132
SGTC_2347 9049783 174.81 µM 0.538227565478255 0.325624082325532 no 1072 0.295209975796873 1488 6467988 YPL169C MEX67
SGTC_2707 st078556 66.6 µM 0.535340702039361 0.326514927153403 no 1073 0.296207143030704 1459 17250899
SGTC_1672 st016598 6.51 µM 0.534792514761536 0.326684201950112 no 1074 0.296396669803648 1383 4665860 YNL267W PIK1
SGTC_341 1486-1430 230 µM 0.534481077573871 0.326780386563824 no 1075 0.296504368866769 1392 2054753 YPL210C SRP72
SGTC_1947 st076332 61.6 µM 0.533791482411043 0.326993402874488 no 1076 0.296742903705665 1431 24208416
SGTC_867 0518-0118 155 µM 0.532601737181912 0.327361048327785 no 1077 0.297154649675968 1454 6848158
SGTC_3184 9108758 49.47 µM 0.530918152355661 0.327881582296133 no 1078 0.297737749086224 1441 902885
SGTC_2980 9014342 25.29 µM 0.529973326729847 0.328173851920494 no 1079 0.29806521222202 1431 2996599
SGTC_169 k015-0017 16.025 µM 0.527099830268159 0.329063377020975 no 1080 0.299062132303792 1519 1840002
SGTC_1548 st061468 90.8 µM 0.520561299745883 0.331091061221982 no 1081 0.301336207342342 1454 390799
SGTC_2205 7238770 200 µM 0.519871557850441 0.331305249686136 no 1082 0.301576550169116 1488 279867
SGTC_1443 4112-3303 14 µM 0.517401525002035 0.332072731769511 no 1083 0.302437947676035 1446 704433
SGTC_1062 mesoridazine 14.2 µM 0.517115612745132 0.332161615256086 no 1084 0.302537727721738 1465 4078 A neuroleptic.
SGTC_2671 danthron 100 µM 0.515757978270312 0.332583801117757 no 1085 0.303011727586387 1433 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2713 st079149 53.4 µM 0.515136288495833 0.332777199972654 no 1086 0.303228893099224 1487 3103253
SGTC_2866 9034245 58.44 µM 0.513344396989944 0.333334880807362 no 1087 0.30385521649943 1534 6462273
SGTC_1214 0358-0031 63.7 µM 0.512426658969906 0.333620646343428 no 1088 0.304176218587242 1654 4301366
SGTC_1429 4049-0205 9.46 µM 0.511558085982357 0.333891191799317 no 1089 0.304480163041861 1471 22774478
SGTC_1488 4013-0813 75.9 µM 0.50929965977383 0.334595056431673 no 1090 0.305271098187681 1445 2910057
SGTC_1226 3909-7979 35.4 µM 0.509033201302661 0.33467813970561 no 1091 0.305364476081894 1534 6615510
SGTC_1009 4106-0057 9.87 µM 0.507223496100878 0.335242630137409 no 1092 0.305999005338151 1474 2928005
SGTC_3134 9127454 49.47 µM 0.504772970241991 0.33600760105831 no 1093 0.306859151294428 1534 24262820
SGTC_3338 9144300 39.5675 µM 0.504587139143554 0.336065638981826 no 1094 0.306924422349364 1502 4901274
SGTC_2071 5230951 39.92 µM 0.50415206491784 0.336201534670515 no 1095 0.307077261148194 1484 1799272
SGTC_628 1636-0253 16 µM 0.503666082059375 0.336353357012236 no 1096 0.307248023465939 1534 4456143
SGTC_2922 7999257 32.47 µM 0.502945961613817 0.336578373630272 no 1097 0.307501132777867 1449 2988377
SGTC_1932 st074806 40.9 µM 0.502040838072058 0.336861281326777 no 1098 0.307819397366785 1551 17251235
SGTC_1600 coumarin 106 71.1 µM 0.501728836074551 0.336958822863835 no 1099 0.307929138785441 1526 100336 A hepatotoxic, DNA x-linker.
SGTC_1252 0493-0875 34.8 µM 0.50055122578866 0.337327079248284 no 1100 0.308343497989701 1459 3960963
SGTC_125 0133-0007 11.75 µM 0.499932834109991 0.337520522041943 no 1101 0.308561185904051 1553 26541
SGTC_1994 st072947 40.9 µM 0.497273187864405 0.33835299085851 no 1102 0.309498208283964 1509 5286565 YDL195W SEC31
SGTC_3291 9121177 71.43 µM 0.494289428972078 0.33928784797698 no 1103 0.310550894831364 1462 17015612
SGTC_1323 1348-1351 11.2 µM 0.493990935896498 0.339381424977496 no 1104 0.310656290436603 1474 6989654
SGTC_1291 0993-0025 5.79 µM 0.4926269365055 0.339809162118949 no 1105 0.311138105785363 1577 4353356
SGTC_1896 st058441 89 µM 0.491243954314908 0.340243062768516 no 1106 0.311626957215456 1438 688759
SGTC_1863 st057641 20.1 µM 0.48994145820135 0.340651905023655 no 1107 0.312087662527014 1493 3921635
SGTC_880 0833-0487 87.2 µM 0.489876018594181 0.340672450894885 no 1108 0.31211081690485 1476 76075
SGTC_1442 4112-3290 3 µM 0.489180983309698 0.340890698138417 no 1109 0.312356785776073 1479 704353
SGTC_1938 st074717 56.4 µM 0.488766722280595 0.341020805113447 no 1110 0.312503430090826 1425 17250979
SGTC_2673 kobusone 100 µM 0.485815797113194 0.341948148528934 no 1111 0.313548886496054 1552 6710676 An epoxy ketone and protein crosslinker.
SGTC_446 go6976 132 µM 0.48572036377921 0.341978154905054 no 1112 0.313582721777329 1563 3501 A protein kinase C inhibitor.
SGTC_834 0312-0008 75.7 µM 0.484984653872763 0.34220951206021 no 1113 0.313843615677736 1518 6385573 YIL048W NEO1
SGTC_2035 5154463 94.595 µM 0.484149068583937 0.34247234866601 no 1114 0.314140039821572 1558 2769623
SGTC_784 4579-0127 173 µM 0.483158101566773 0.34278416010133 no 1115 0.314491741141219 1636 1948547
SGTC_244 nsc-207895 1.295 µM 0.482451790614665 0.343006468859086 no 1116 0.314742518800127 1418 42640
SGTC_2112 5488546 200 µM 0.48058537605207 0.343594177363281 no 1117 0.315405605536312 1473 600757
SGTC_1007 4101-0031 70 µM 0.479406396002733 0.343965617155959 no 1118 0.315824772103354 1606 1146276
SGTC_925 2064-1272 59.6 µM 0.479340851284021 0.34398627156099 no 1119 0.315848082385784 1485 6815817
SGTC_1107 amlodipine 47 µM 0.477922317643098 0.344433392840827 no 1120 0.316352748108633 1455 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1157 4092-0394 27.6 µM 0.476543719590788 0.344868134840127 no 1121 0.316843534058911 1608 3659885
SGTC_3052 9092717 49.47 µM 0.475317784360456 0.345254906644109 no 1122 0.317280242444748 1506 25237534
SGTC_2992 9074591 71.4286 µM 0.472032080241264 0.34629231384038 no 1123 0.318451945296866 1519 17741321
SGTC_1900 st060200 72.8 µM 0.470655101328048 0.346727416048806 no 1124 0.318943526037539 1522 688945
SGTC_572 0960-0087 17.7 µM 0.469903440558598 0.346965013596362 no 1125 0.31921200304308 1456 6796365
SGTC_1467 k284-1082 293 µM 0.46933229388267 0.347145591464941 no 1126 0.3194160677303 1610 3334705
SGTC_3073 9114972 49.47 µM 0.469054889909933 0.347233310039946 no 1127 0.319515200987767 1618 41905075
SGTC_414 piperonyl butoxide 100 µM 0.467237046381159 0.347808337054104 no 1128 0.320165145659456 1484 5794 A potent inhibitor of cytochrome P450.
SGTC_3312 9133330 71.43 µM 0.466772061182731 0.347955479203893 no 1129 0.320331483417279 1609 17617324
SGTC_2727 riluzole 51.77 µM 0.466323722166732 0.348097375439625 no 1130 0.320491900577079 1527 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1073 triclabendazole 3.09 µM 0.465854306190536 0.348245965183149 no 1131 0.320659895085893 1562 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1766 st045414 44.774 µM 0.46561759731582 0.348320902256299 no 1132 0.320744622353878 1531 253960
SGTC_2332 7982454 138.89 µM 0.465130294622751 0.348475190724989 no 1133 0.320919076246418 1510 2981748
SGTC_1347 1493-0251 600 nM 0.464801709702227 0.348579240553726 no 1134 0.32103673165503 1640 3986378
SGTC_1804 st050076 49.1 µM 0.464098567840811 0.348801935995161 no 1135 0.321288563894824 1573 3895976
SGTC_301 4119-0100 24.5 µM 0.461709213879087 0.349559068710815 no 1136 0.322144931366435 1568 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1861 st057647 17.4 µM 0.460982781268814 0.349789377774368 no 1137 0.322405479366115 1655 688668
SGTC_2475 5812728 15.03 µM 0.458526412538552 0.350568556948483 no 1138 0.323287145574921 1500 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1998 st075797 76.8 µM 0.458322703078271 0.350633203460204 no 1139 0.323360307833309 1577 24208315
SGTC_1948 st076329 66.6 µM 0.456296459479951 0.351276460275055 no 1140 0.324088404787825 1473 24208413
SGTC_1789 tunicamycin 25 nM 0.454448982342897 0.35186333700539 no 1141 0.324752852026038 1513 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_500 h-89 112 µM 0.453575889316176 0.352140810074806 no 1142 0.325067055224546 1674 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_842 0271-0008 11.1 µM 0.451895055098083 0.352675208687235 no 1143 0.325672293471331 1601 1221709
SGTC_2624 nerol 100 µM 0.450647754307514 0.353071959253515 no 1144 0.326121721444217 1636 637566 A natural product oil.
SGTC_2342 7990637 118.86 µM 0.449195188949037 0.353534203250653 no 1145 0.326645428888676 1590 2033102 YER133W GLC7
SGTC_1035 k081-0041 55.2 µM 0.448530187811808 0.35374589602186 no 1146 0.326885302303591 1589 731709
SGTC_1671 st016596 74.5 µM 0.447955781099793 0.353928785878728 no 1147 0.327092554889708 1552 2829167
SGTC_1334 1486-0610 236 µM 0.446994366359278 0.354234973668015 no 1148 0.327439563763627 1579 3742339
SGTC_2121 5257820 149.641 µM 0.446030455186456 0.354542051139172 no 1149 0.327787623428305 1651 791256
SGTC_991 3996-0057 64.7 µM 0.444376413234852 0.355069206916275 no 1150 0.328385231753917 1576 715343
SGTC_357 1325-0123 420 µM 0.444126559812754 0.355148861258641 no 1151 0.328475542477403 1638 1098503
SGTC_2617 dihydrotanshinone i 20.83 µM 0.443164970835446 0.355455478981685 no 1152 0.328823206914776 1531 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2442 5158906 48.48 µM 0.440896079315025 0.356179321201231 no 1153 0.329644116089635 1656 1893835
SGTC_2899 9053889 58.44 µM 0.440403233588399 0.356336621933024 no 1154 0.32982254166974 1604 6470052
SGTC_1752 st044819 83.042 µM 0.440017807014242 0.356459654913346 no 1155 0.329962105144848 1497 441209 YML126C ERG13
SGTC_1628 st004252 77.7 µM 0.438457569005328 0.356957854920779 no 1156 0.330527311090366 1684 692968
SGTC_1269 0831-0796 3.05 µM 0.436858061480106 0.357468847428179 no 1157 0.331107144166937 1644 927758
SGTC_875 0709-0210 25.7 µM 0.436442035581392 0.357601796590108 no 1158 0.331258023039035 1620 6251364
SGTC_1726 st035556 14.5795 µM 0.436064016177298 0.357722615023544 no 1159 0.33139514196727 1664 5919439
SGTC_1677 st019204 53.9 µM 0.434502152953309 0.358221951710563 no 1160 0.331961915870494 1512 3945625
SGTC_1996 st072960 66.8 µM 0.434453733999198 0.358237435410691 no 1161 0.331979492449472 1626 1719405
SGTC_1053 3366-3204 134 µM 0.434441726482477 0.358241275281634 no 1162 0.331983851358917 1541 3632071 YPR165W RHO1
SGTC_420 mitomycin C 81.9 mM 0.433803002397515 0.358445552830991 no 1163 0.332215750585367 1544 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_359 0081-0058 15.9 µM 0.432863208123405 0.358746192678164 no 1164 0.332557075086439 1726 3494159
SGTC_3325 9138760 55.175 µM 0.43272231723926 0.3587912711708 no 1165 0.332608257316254 1528 43844959
SGTC_1980 st071811 45.7 µM 0.432652377642941 0.358813649300731 no 1166 0.332633665828765 1628 4974850
SGTC_533 1222-0222 6.71 µM 0.432453670470528 0.358877231021097 no 1167 0.33270585879725 1675 3982874
SGTC_553 k007-0256 45.7 µM 0.431027002424652 0.359333846677339 no 1168 0.333224368378032 1601 6287000
SGTC_1960 st011366 51.8 µM 0.430525961926049 0.359494256110029 no 1169 0.333406542729358 1563 3972846
SGTC_2653 dihydrofissinolide 100 µM 0.430081992901304 0.359636414653856 no 1170 0.333567999187862 1607 6857746
SGTC_235 0330-0087 5 mM 0.429741920487225 0.359745318721258 no 1171 0.333691692831791 1565 46494818 YHR062C RPP1
SGTC_2495 cafestol 54.53 µM 0.426094189439976 0.360914174993729 no 1172 0.335019607013065 1618 16667697 An anti-infammatory.
SGTC_2107 5363541 170.161 µM 0.425962903531742 0.360956267738431 no 1173 0.335067438720526 1589 244052
SGTC_3250 9135583 49.47 µM 0.42596233026008 0.360956451543859 no 1174 0.335067647587822 1670 7699353
SGTC_1262 0737-0114 49.6 µM 0.425769256231586 0.361018357798424 no 1175 0.335137995584825 1643 765919
SGTC_3084 9116877 49.47 µM 0.423162247724406 0.361854611350103 no 1176 0.336088444413693 1658 27241325
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.422918550134851 0.361932816341985 no 1177 0.336177344040512 1549 61125 An anti-inflammatory.
SGTC_79 0052-0007 94.094 µM 0.422215143728824 0.362158578814187 no 1178 0.336433994455777 1687 2801472
SGTC_380 3970-0968 6 µM 0.421832176698191 0.362281514531232 no 1179 0.336573758888285 1548 2891601
SGTC_736 0958-0254 92.6 µM 0.421708888098491 0.362321094257416 no 1180 0.336618758066212 1649 6812352
SGTC_2819 7996655 46.38 µM 0.421382985109043 0.362425727003877 no 1181 0.336737720853641 1658 6456960
SGTC_3237 9133362 49.47 µM 0.420695499376303 0.362646481354719 no 1182 0.336988724007891 1654 43845137
SGTC_918 glabranin 770.725 nM 0.418949831699563 0.363207227102078 no 1183 0.337626398664831 1648 124049 Also referred to as licorice root.
SGTC_3220 9131269 49.47 µM 0.417435311329014 0.363693961088577 no 1184 0.338180015578079 1594 17722206
SGTC_1192 1488-0095 21.4 µM 0.41581151714368 0.364216057764654 no 1185 0.33877396526931 1606 915875
SGTC_1229 0139-0193 12.2 µM 0.415462708059196 0.364328242872075 no 1186 0.338901604668531 1710 3090752
SGTC_2787 5284540 71.43 µM 0.414986635289051 0.364481377695922 no 1187 0.339075843406483 1598 736958
SGTC_2202 7226349 200 µM 0.414566778640054 0.364616447845218 no 1188 0.339229536074085 1573 844334
SGTC_1039 k821-0043 94 µM 0.413622362600342 0.364920332986238 no 1189 0.339575346619465 1709 15992768
SGTC_1898 st060199 18.6 µM 0.413343964433883 0.365009929484867 no 1190 0.339677311622132 1571 688866
SGTC_2219 9098279 200 µM 0.413090933110859 0.365091368601272 no 1191 0.339769996045161 1694 902349
SGTC_3178 9107506 49.47 µM 0.412268200833715 0.365356210231715 no 1192 0.340071426726619 1630 8897194
SGTC_66 0109-0187 42.4 µM 0.412024373823069 0.365434711706386 no 1193 0.340160779134022 1533 759417
SGTC_3022 9087993 49.47 µM 0.411110411657197 0.36572901710206 no 1194 0.34049578791893 1655 17173644
SGTC_1933 st074711 15.9 µM 0.410984918632963 0.365769433346897 no 1195 0.34054179666673 1562 17250958
SGTC_1094 duloxetine 25.4 µM 0.410809464477337 0.365825942556062 no 1196 0.340606126339713 1616 60834 A selective serotonin reuptake inhibitor.
SGTC_770 0389-1121 67.2 µM 0.410530458263601 0.365915809178685 no 1197 0.340708432573613 1730 6753108
SGTC_343 4130-2827 29.8 µM 0.408719049323037 0.366499434437832 no 1198 0.341372926258936 1588 1118244
SGTC_2693 st077581 40.7 µM 0.408557167996234 0.366551606698692 no 1199 0.341432334468808 1625 25238761
SGTC_38 0929-0051 58.268 µM 0.407283923448234 0.366962042876519 no 1200 0.341899734509178 1766 1379719
SGTC_3105 9121040 49.47 µM 0.407261205057554 0.366969367635863 no 1201 0.341908076490482 1576 41448907
SGTC_3028 9087778 49.47 µM 0.407018894289347 0.367047495375012 no 1202 0.341997055547105 1536 17217395
SGTC_1088 bifonazole 369 nM 0.406073816443953 0.367352267381272 no 1203 0.342344181873386 1606 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_515 4092-1064 102 µM 0.405205672928593 0.367632302996655 no 1204 0.342663167703022 1748 717353
SGTC_15 0266-0086 27.098 µM 0.405198947031371 0.367634472833156 no 1205 0.342665639467708 1678 1712902 YIL048W NEO1
SGTC_1342 1486-1464 234 µM 0.404924573280973 0.367722991937655 no 1206 0.342766477458646 1604 3253938
SGTC_675 1309-0189 238 µM 0.404536375816466 0.367848245119685 no 1207 0.342909167141503 1582 4246530
SGTC_1018 4259-0013 28.1 µM 0.403936552151476 0.368041807818456 no 1208 0.343129688292943 1650 6801262
SGTC_2056 5235370 200 µM 0.40344688814311 0.368199846914293 no 1209 0.343309749604863 1587 5511916
SGTC_2856 9022925 19.48 µM 0.399452365957686 0.369489910266048 no 1210 0.344779957735872 1641 4944862
SGTC_1556 plumbagin 1.48 µM 0.3993790335583 0.369513607351345 no 1211 0.34480697017688 1616 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_845 0330-0138 4.51 µM 0.39910951655509 0.3696007050016 no 1212 0.344906255221208 1712 9039800
SGTC_2812 7970281 58.44 µM 0.398491832048963 0.369800342388798 no 1213 0.345133838966934 1740 2233435
SGTC_1220 1838-0075 193 µM 0.39843817537282 0.369817686036521 no 1214 0.345153611231719 1659 5529645
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.396803990721144 0.370346036339404 no 1215 0.345756003827512 1568 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1833 st055984 71 µM 0.39593565687372 0.370626878072529 no 1216 0.346076247819195 1641 676288
SGTC_2070 5230947 200 µM 0.394337404450873 0.371143974602175 no 1217 0.346665975583292 1700 2835538
SGTC_460 trequinsin 123 µM 0.394215728020012 0.371183351182606 no 1218 0.346710887347804 1649 5537 A vasodilator.
SGTC_2425 5628681 7.85 µM 0.393181632855109 0.371518056512754 no 1219 0.347092667219414 1740 5714958
SGTC_3164 9100705 49.47 µM 0.391022165531266 0.37221732383448 no 1220 0.347890425953599 1718 17174235
SGTC_750 4073-0104 132 µM 0.390679251622864 0.37232840325402 no 1221 0.348017168615204 1567 22330957
SGTC_653 0203-0016 55.2 µM 0.389321810724084 0.372768220554571 no 1222 0.348519051958387 1684 295302
SGTC_276 colchicine 750 µM 0.388715324276081 0.372964778705756 no 1223 0.348743372521555 1671 2833 A microtubule depolymerizer.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.387317457475995 0.373417943762656 no 1224 0.349260601501233 1628 5106787 A p450 inhibitor.
SGTC_1768 st044301 37.178 µM 0.387193438529541 0.373458157099017 no 1225 0.349306503672634 1589 3931349
SGTC_1333 1482-0047 286 µM 0.385075936889134 0.374144972596991 no 1226 0.350090577756423 1749 3811116
SGTC_2355 9061122 103.12 µM 0.384890159284804 0.374205249001882 no 1227 0.350159398539202 1749 5302957
SGTC_1481 3346-2004 36 µM 0.38383840330629 0.374546554053701 no 1228 0.350549111271534 1650 2770522
SGTC_1945 st075991 56.6 µM 0.382467051768428 0.374991718610498 no 1229 0.351057481739857 1614 1084980
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.380368437497099 0.375673287663337 no 1230 0.351835970144852 1664 5379071
SGTC_2753 fluvastatin 17.09 µM 0.380109403690653 0.375757441285142 no 1231 0.351932102815761 1669 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_493 zm226600 134 µM 0.378318913762732 0.376339288213692 no 1232 0.352596848293714 1679 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2701 st077767 14.721 µM 0.377794194871814 0.376509856921333 no 1233 0.352791743254569 1651 5721188
SGTC_2314 7727897 200 µM 0.37728845242548 0.376674279839429 no 1234 0.352979626413108 1608 900724
SGTC_2775 cyproheptadine 69.59 µM 0.374648580847168 0.377532896237962 no 1235 0.353960918937479 1714 2913 A selective serotonin reuptake inhibitor.
SGTC_3266 9136860 49.47 µM 0.374098027024428 0.37771203994734 no 1236 0.354165693257056 1642 4871271 YPR165W RHO1
SGTC_419 nsc-638432 893 µM 0.373851804349824 0.377792166412388 no 1237 0.354257287567222 1650 368090
SGTC_1297 1068-0111 14.1 µM 0.373737387970948 0.377829401897193 no 1238 0.354299853085992 1605 767057
SGTC_573 3702-0553 84.7 µM 0.373474073910782 0.377915098718986 no 1239 0.354397818873248 1670 1222756
SGTC_2755 lomerizine 42.69 µM 0.373459000092815 0.377920004747087 no 1240 0.354403427366882 1618 3949 A calcium channel blocker.
SGTC_1461 k072-0203 53.8 µM 0.373135727436616 0.37802522401907 no 1241 0.354523714553587 1625 5418714
SGTC_957 1187-1561 14.1 µM 0.372737058302867 0.378154995909747 no 1242 0.354672076150849 1659 1538454
SGTC_2421 5690543 90.72 µM 0.372615414953408 0.378194595110338 no 1243 0.354717349162056 1697 3397993
SGTC_2 0422-0095 29 µM 0.371765765535524 0.3784712216222 no 1244 0.355033627403798 1657 6790840
SGTC_608 k048-0125 159 µM 0.370905344441209 0.378751418628026 no 1245 0.355354017180565 1762 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2861 9024595 19.48 µM 0.369744464226129 0.379129561447099 no 1246 0.355786449122117 1687 16482810
SGTC_2987 9018338 71.43 µM 0.36650364769551 0.380185829871119 no 1247 0.356994645610059 1679 5055682
SGTC_2221 6807166 181.081 µM 0.366072158705975 0.380326531248918 no 1248 0.357155615936398 1732 674925
SGTC_617 3770-0098 35 µM 0.363552650113159 0.381148416706612 no 1249 0.358096045121476 1698 5962639
SGTC_1434 4073-0095 163 µM 0.362149398897695 0.381606402189069 no 1250 0.358620195215645 1727 24133745
SGTC_1019 4262-0212 3.4 µM 0.35942863515515 0.382494862099691 no 1251 0.359637228118801 1815 4677213
SGTC_1354 1498-1681 81 µM 0.358591776261686 0.382768261352581 no 1252 0.359950249890945 1701 5754243
SGTC_759 3486-0358 89.3 µM 0.357752941739743 0.383042364672589 no 1253 0.360264104916234 1857 875103
SGTC_2955 9076254 12.21 µM 0.354585605546107 0.384077872239874 no 1254 0.361450030725551 1830 16459619
SGTC_3204 9114183 49.47 µM 0.354254060208991 0.384186313442533 no 1255 0.361574246394139 1628 17027248
SGTC_1707 st032323 6.317 µM 0.353345652581758 0.384483480067612 no 1256 0.361914662079233 1726 3132057 YMR211W DML1
SGTC_11 0438-0307 1.3 µM 0.350041261748672 0.385565014163075 no 1257 0.363153865863299 1804 4011476
SGTC_2643 anethole 100 µM 0.349780957520161 0.385650250228505 no 1258 0.363251545550608 1712 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_562 3772-2733 112 µM 0.348094189325796 0.386202712543993 no 1259 0.363884724013113 1797 2876874 YIL048W NEO1
SGTC_3059 1327-0034 3 µM 0.347945454566554 0.386251438299749 no 1260 0.363940573880332 1664 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2474 5321570 43.32 µM 0.345918675951231 0.386915592845847 no 1261 0.36470191637086 1801 2841384
SGTC_3295 9122362 53.5725 µM 0.345456316838572 0.387067149655566 no 1262 0.364875672615755 1687 4730473
SGTC_482 fipronil 114 µM 0.345362240715 0.387097989000682 no 1263 0.364911030166224 1747 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1700 st030840 7.9285 µM 0.343863419056756 0.387589417732525 no 1264 0.365474501747817 1832 5499307
SGTC_2641 levomentholum 100 µM 0.339786025905677 0.388927209558275 no 1265 0.367008836092363 1768 16666
SGTC_4 0960-0234 25.671 µM 0.337683913690611 0.389617428092141 no 1266 0.367800699212552 1706 6821112
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.336800948816593 0.389907449406476 no 1267 0.368133478885709 1703 442882
SGTC_2764 methyldopa 94.69 µM 0.33518713134174 0.390437687087213 no 1268 0.36874196441232 1834 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3009 9080819 71.4286 µM 0.335068901090099 0.390476540977199 no 1269 0.368786555770654 1705 17027216
SGTC_1909 st060837 51.5 µM 0.334593535504877 0.390632770932615 no 1270 0.368965861018224 1690 678937
SGTC_205 1486-1330 71.903 µM 0.333909654927576 0.390857560772058 no 1271 0.369223866980131 1752 4118834
SGTC_3352 9151559 45.5865 µM 0.333695966932831 0.390927806965312 no 1272 0.36930449661736 1688 17159339
SGTC_2625 euphol 100 µM 0.332755889173294 0.391236883337256 no 1273 0.36965927888448 1855 6708538 A triterpene alcohol.
SGTC_151 3013-0144 2.285 µM 0.330760444350349 0.391893168042301 no 1274 0.370412720742021 1829 906558 YHR107C CDC12
SGTC_481 bay k-8644 50 µM 0.330266104469084 0.392055799825486 no 1275 0.370599451026146 1688 2303 A calcium channel antagonist.
SGTC_233 rapamycin 362 pM 0.330093503870885 0.39211258775771 no 1276 0.370664655778726 1766 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_509 pifithrin 175 µM 0.328652457343124 0.392586801141792 no 1277 0.371209196645587 1783 4817 A p53 inhibitor.
SGTC_614 0462-0418 107 µM 0.328599747114994 0.392604149824855 no 1278 0.371229119617392 1719 5188303
SGTC_406 estrone 100 µM 0.328260611437487 0.392715775718274 no 1279 0.371357311538822 1854 5870 A steroid.
SGTC_1623 st003709 20.3 µM 0.32351326340637 0.394279279162172 no 1280 0.373153282196903 1688 16192618
SGTC_2975 9084847 53.72 µM 0.323428777921059 0.394307119338247 no 1281 0.373185269033572 1725 27211724
SGTC_371 0195-0006 7.36 µM 0.322699658828269 0.394547405564003 no 1282 0.373461355274936 1659 3928593
SGTC_836 0330-0104 1.35 µM 0.322687621484583 0.394551372890598 no 1283 0.373465913848071 1768 46494820
SGTC_270 tamoxifen 5.46 µM 0.322186553531307 0.394716527015451 no 1284 0.373655685277865 1878 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2900 5328528 85.29 µM 0.319183063241379 0.39570688585033 no 1285 0.374793849688738 1694 795359
SGTC_2150 5556613 200 µM 0.318936778329472 0.395788124823415 no 1286 0.374887227233129 1780 743190
SGTC_1091 telmisartan 47.6 µM 0.318653494558288 0.395881573753357 no 1287 0.37499464175808 1827 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1052 3253-3998 198 µM 0.318282057338896 0.396004111585776 no 1288 0.375135496682678 1719 5450317
SGTC_623 k072-0108 16.9 µM 0.317483115164626 0.396267718913953 no 1289 0.375438524723164 1776 5382803
SGTC_1335 1486-0900 202 µM 0.316804663270057 0.39649160827146 no 1290 0.3756959127822 1746 X1335
SGTC_598 3937-0236 20.2 µM 0.315954395624123 0.396772245074598 no 1291 0.376018561643077 1812 1379313
SGTC_3152 9099253 49.47 µM 0.315878384003577 0.396797335849381 no 1292 0.37604740980024 1819 25236131
SGTC_3273 9137859 49.47 µM 0.314945519413467 0.397105301105434 no 1293 0.376401509722989 1792 2377234
SGTC_2091 4-phenylthiadiazole 200 µM 0.314705757935772 0.397184463593402 no 1294 0.376492536021507 1746 270010
SGTC_2296 7971656 126.45 µM 0.314564820234416 0.397230999230439 no 1295 0.376546046727285 1724 666570
SGTC_1452 4194-0072 190 µM 0.313715567477439 0.397511441434406 no 1296 0.376868538060594 1896 1343545
SGTC_1380 2291-0730 164 µM 0.3128945423271 0.39778261262593 no 1297 0.377180392068687 1722 2999191
SGTC_2005 4024620 188 µM 0.312786833566773 0.397818190737266 no 1298 0.377221309564386 1742 236743
SGTC_2825 7998094 58.44 µM 0.312026697517128 0.398069301284125 no 1299 0.377510116921493 1759 2987815
SGTC_2435 5706476 10.6 µM 0.311135140104285 0.398363880611582 no 1300 0.377848944018151 1917 5725375
SGTC_2224 6650123 117.647 µM 0.310841159364968 0.398461027443899 no 1301 0.377960688952423 1772 2908370
SGTC_516 3992-2719 87.3 µM 0.30869297564087 0.399171091940982 no 1302 0.378777543837237 1640 5350887 YDR037W KRS1
SGTC_295 k015-0027 31 µM 0.307859612790207 0.399446643170083 no 1303 0.379094579239333 1798 3887424
SGTC_2456 5770359 74.46 µM 0.307169619192156 0.399674827307965 no 1304 0.379357134387618 1854 3118787
SGTC_1840 st055363 71 µM 0.30388229209136 0.400762431175814 no 1305 0.380608784545447 1698 676033
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.303778914191617 0.400796646019938 no 1306 0.380648166045032 1744 6708760
SGTC_1952 st077036 64.1 µM 0.301498127489896 0.401551708088339 no 1307 0.381517338832037 1816 2937007
SGTC_2925 9010536 32.5 µM 0.301410387703397 0.401580762000997 no 1308 0.381550787086247 1835 2994177
SGTC_2879 9041815 71.43 µM 0.300840999742976 0.401769320785843 no 1309 0.381767871252899 1846 4942971
SGTC_3320 9137005 35.139 µM 0.299462994660009 0.402225756167206 no 1310 0.38229340159299 1765 4908713
SGTC_956 1185-0240 191 µM 0.297940114547992 0.40273033347559 no 1311 0.382874435259465 1797 1416193
SGTC_1435 4092-0789 56.7 µM 0.296666436859208 0.403152466799813 no 1312 0.383360591764505 1876 2248285
SGTC_3281 9140613 49.47 µM 0.294934865985583 0.403726540039713 no 1313 0.384021818390961 1696 16013766
SGTC_810 3825-7150 143 µM 0.294930795370069 0.40372788982882 no 1314 0.384023373215961 1956 22330411 YGL099W LSG1
SGTC_2411 st077133 39.94 µM 0.29170990174016 0.4047962748913 no 1315 0.385254218928346 1935 1403142 YNL221C POP1
SGTC_2956 9076196 2.52 µM 0.290077738577203 0.405337942438464 no 1316 0.385878382997856 1869 16423868
SGTC_3058 9093861 49.47 µM 0.288745363358004 0.405780253579619 no 1317 0.386388122789796 1844 17217477
SGTC_755 1995-0008 37.3 µM 0.288027028668597 0.406018770471523 no 1318 0.38666302453667 1869 689533
SGTC_1957 st077035 62.4 µM 0.287196385834007 0.406294621813894 no 1319 0.38698097674839 1845 705593
SGTC_2903 5923464 63.88 µM 0.285321591014761 0.406917400348211 no 1320 0.387698886402211 1927 2876576
SGTC_2465 5809242 33.21 µM 0.285062000371026 0.407003651033784 no 1321 0.387798321010715 1855 2731748
SGTC_1409 3909-8004 61.9 µM 0.28409164167487 0.407326098951624 no 1322 0.388170076086944 1825 2119279
SGTC_98 0074-0023 107.663 µM 0.282978675173768 0.407696012431913 no 1323 0.388596591958307 1757 3563821
SGTC_2999 9069765 71.4286 µM 0.282601743462528 0.407821310817458 no 1324 0.388741071850551 1860 2097066
SGTC_2459 5811157 9.22 µM 0.282534687354486 0.407843602374078 no 1325 0.388766776419876 1886 2870684 YBR192W RIM2
SGTC_2298 7976326 193.81 µM 0.282351412358675 0.40790453026137 no 1326 0.388837033575438 1874 2235818
SGTC_2576 guaiol 23.12 µM 0.282318513450279 0.407915467400909 no 1327 0.388849645521045 1963 227829
SGTC_2490 carminic acid 95.39 µM 0.281614082442679 0.408149670497781 no 1328 0.389119720426113 1829 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2007 4011539 71.82 µM 0.281463023789813 0.408199897441461 no 1329 0.389177642449316 1753 45595301
SGTC_2531 methyl deoxycholate 70.07 µM 0.281092502085041 0.408323102150719 no 1330 0.389319725947045 1771 16667744 Haematoxylin.
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.279626708831005 0.408810591835916 no 1331 0.389881956765946 1835 88881 An O-methylated flavonoid and antioxidant.
SGTC_1503 4585-0012 61.3 µM 0.278723719552854 0.409110975935654 no 1332 0.390228429011191 1890 2922052
SGTC_632 0781-2353 4.65 µM 0.277380717168348 0.409557831382178 no 1333 0.390743893209906 1863 6811515 YHR007C ERG11
SGTC_1075 aripiprazole 15.2 µM 0.276565856256408 0.409829016321693 no 1334 0.391056742564344 1798 60795 An atypical antipschotic. YIL048W NEO1
SGTC_606 k015-0008 38.6 µM 0.276537250844647 0.409838536960152 no 1335 0.391067726315447 1934 1970475
SGTC_1382 3002-2117 298 µM 0.276216792939024 0.409945197468522 no 1336 0.391190779943619 1931 1497314
SGTC_3300 9124615 50.48 µM 0.275750066014755 0.4101005537553 no 1337 0.391370019349234 1875 24824903
SGTC_1950 st077106 7.18 µM 0.274304204179837 0.41058191763413 no 1338 0.391925426956706 1780 13831864
SGTC_485 niflumic acid 177 µM 0.274267049679401 0.410594289083135 no 1339 0.391939702246702 1874 4488 A COX2 inhibitor.
SGTC_2940 9060638 45.86 µM 0.274030430585144 0.41067307896195 no 1340 0.392030618096369 1828 4027022
SGTC_2928 9011484 9.79 µM 0.27235984452553 0.411229456296306 no 1341 0.392672672695433 1807 2994751
SGTC_1971 st069429 63.5 µM 0.271559906720852 0.411495933449299 no 1342 0.392980215517291 1949 1246522 YGL099W LSG1
SGTC_1441 4106-0040 13 µM 0.2715525168122 0.411498395383491 no 1343 0.392983056941624 1844 2904180
SGTC_3299 9121982 43.1275 µM 0.270394653242905 0.411884178443214 no 1344 0.393428326526982 1801 17594604 YPL160W CDC60
SGTC_688 0527-0193 473 µM 0.269437479816186 0.412203158841105 no 1345 0.393796523734304 1863 4007154
SGTC_3135 9127742 49.47 µM 0.26842614405083 0.412540251994765 no 1346 0.39418565881852 1792 3643468
SGTC_2241 6772625 37.8075 µM 0.267836337144944 0.412736873153304 no 1347 0.394412649616113 1865 2285411
SGTC_2847 9005661 71.43 µM 0.265966266111905 0.413360434503551 no 1348 0.395132594654674 1899 2991449
SGTC_394 menadione 8.33 µM 0.265789076698462 0.413419528364317 no 1349 0.395200828130366 1953 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2526 patulin 37.61 µM 0.265611749965431 0.413478669985666 no 1350 0.395269117703419 1853 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3003 9075612 71.4286 µM 0.265433659886764 0.413538068172101 no 1351 0.395337704482704 1847 6501993
SGTC_1716 st033144 30.6155 µM 0.264197206612308 0.413950515547346 no 1352 0.395813981711635 1952 674617
SGTC_164 4100-3994 89.624 µM 0.263135601153589 0.414304714185141 no 1353 0.396223032392234 1989 4615967
SGTC_128 0906-2981 13.371 µM 0.262743607676524 0.414435518220889 no 1354 0.396374101597156 1955 6740226
SGTC_926 2268-1401 59.4 µM 0.261693571597109 0.414785950762472 no 1355 0.396778848497183 1934 2931578
SGTC_2276 7947513 42.08 µM 0.261250876672513 0.414933713367261 no 1356 0.39694952303788 1681 2105100
SGTC_2710 st078562 53.7235 µM 0.259356880673411 0.415566026537515 no 1357 0.397679947948513 1849 17250908
SGTC_2977 9011197 71.43 µM 0.258834006335141 0.415740627446219 no 1358 0.397881659234143 1919 2704722
SGTC_3 0833-0587 95.581 µM 0.258150051608959 0.415969042259693 no 1359 0.398145552337528 1872 5382644
SGTC_858 0438-0351 2.77 µM 0.256819846479283 0.4164133613101 no 1360 0.398658924266707 1820 2799119
SGTC_891 0929-0073 133 µM 0.256024641196179 0.41667902918702 no 1361 0.398965905174998 1925 5603632
SGTC_548 1436-0017 110 µM 0.255809588873822 0.416750881950548 no 1362 0.399048934680984 1960 9677137
SGTC_1606 st000094 49.2 µM 0.254204916917291 0.417287118723436 no 1363 0.399668626100193 2005 1242210
SGTC_284 0988-0104 32.6 µM 0.25390319017869 0.417387964631896 no 1364 0.399785175067027 1932 4666532
SGTC_1924 st058459 75.1 µM 0.253527713478001 0.417513467525008 no 1365 0.39993022413958 1903 688683
SGTC_2669 eugenol 100 µM 0.252923848483715 0.417715326706787 no 1366 0.400163530037252 1970 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1999 st074831 12.5 µM 0.252096561668027 0.417991906227012 no 1367 0.400483213775074 1829 17112523
SGTC_2695 st077686 51.995 µM 0.250797156377197 0.41842640680428 no 1368 0.40098547010644 1819 2876092
SGTC_2448 5185112 27.17 µM 0.250791297509008 0.418428366142984 no 1369 0.400987735093482 1857 5718189
SGTC_1660 st012960 28.1 µM 0.248862698300778 0.419073443266773 no 1370 0.401733495051689 1861 24207266
SGTC_1041 0206-0046 107 µM 0.248760922166427 0.419107491369305 no 1371 0.401772860301709 1840 50494
SGTC_2906 7926292 26.41 µM 0.248213395566086 0.419290670848436 no 1372 0.401984651222769 1863 2966319
SGTC_2302 7771753 200 µM 0.247926585001237 0.41938663264135 no 1373 0.402095605039426 1790 2203047
SGTC_3002 9075603 71.4286 µM 0.246050913846308 0.420014317328694 no 1374 0.402821410074209 1953 20105405
SGTC_2473 5854593 8.94 µM 0.245474253295386 0.420207335093837 no 1375 0.403044620652568 1854 2872951
SGTC_2131 toluylene red 5.2905 µM 0.244036279813056 0.420688731953492 no 1376 0.403601360969021 1825 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_424 splitomicin 100 mM 0.243914420252488 0.420729532890136 no 1377 0.403648550342037 1785 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2426 5582046 32.21 µM 0.243024330228852 0.421027578036144 no 1378 0.403993274782699 1921 2251934
SGTC_1445 4239-0156 97.7 µM 0.238116223610606 0.422671857765021 no 1379 0.405895475982974 1997 4008346
SGTC_2201 6605497 169.863 µM 0.237926732615402 0.422735366934621 no 1380 0.405968960582797 1970 670741
SGTC_1127 asiatic acid 681.4 nM 0.237812217376861 0.422773748453516 no 1381 0.406013371193672 1787 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2303 7774051 200 µM 0.236509778990108 0.423210331930998 no 1382 0.40651855998278 1980 2953184
SGTC_2253 7938677 135.83 µM 0.235796335101372 0.423449521694249 no 1383 0.406795356074778 2009 2301972
SGTC_1612 st002233 45.4 µM 0.235205239216401 0.423647714343151 no 1384 0.407024719874675 1979 1035021
SGTC_2883 9059145 45.46 µM 0.23435795034174 0.423931841399153 no 1385 0.407353550214287 1861 16476510
SGTC_873 0591-4978 488 µM 0.23422540921184 0.423976290885121 no 1386 0.40740499495224 2050 3305145
SGTC_1530 rhein 70.4 µM 0.23401050431425 0.424048364245589 no 1387 0.407488411895858 1972 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2850 9015429 58.44 µM 0.232866252419965 0.424432158472577 no 1388 0.407932632374181 1854 6457570
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.231460656983927 0.424903708144972 no 1389 0.408478473384771 1910 4620898
SGTC_1179 1021-1431 9.29 µM 0.230295383525591 0.425294716027056 no 1390 0.408931123814714 1918 2840958
SGTC_2020 4017018 200 µM 0.228168773310558 0.426008489950726 no 1391 0.409757518228459 1879 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_82 0054-0107 293.755 µM 0.227959321979442 0.426078803199887 no 1392 0.409838932148219 2019 3104697
SGTC_968 1309-0633 340 µM 0.225695286161646 0.426838994292927 no 1393 0.410719212299952 2026 3761976
SGTC_1839 st053978 48 µM 0.223082295766909 0.427716690947057 no 1394 0.411735728552259 2028 3788398
SGTC_910 3454-3003 490 µM 0.222711382734783 0.427841308767847 no 1395 0.411880070855021 2046 820824
SGTC_1914 st062367 72.6 µM 0.222331144392622 0.427969067139451 no 1396 0.412028054517204 1880 978205
SGTC_2152 5568786 200 µM 0.222328905582072 0.427969819392094 no 1397 0.412028925869306 1931 5399883
SGTC_2791 5663188 71.43 µM 0.222194736611889 0.428014901381001 no 1398 0.412081145645876 1994 54690634
SGTC_1273 0849-0096 14.1 µM 0.220786613252563 0.428488100151499 no 1399 0.412629293728784 1890 5286025
SGTC_3229 9132204 49.47 µM 0.220201583019101 0.428684729386606 no 1400 0.412857081907543 1952 17682924
SGTC_231 b-estradiol 524 µM 0.219948086304912 0.428769935380881 no 1401 0.412955792855219 1883 450 A steroid.
SGTC_1320 1313-0481 95.3 µM 0.219550533768638 0.428903568488162 no 1402 0.413110609839542 2021 6813365 YLR208W SEC13
SGTC_1259 0671-0132 43 µM 0.21859281636936 0.429225528565494 no 1403 0.413483624594034 1882 X1259
SGTC_2795 7780010 54.55 µM 0.217274745439313 0.429668707234432 no 1404 0.413997118602595 1928 953673
SGTC_2172 5754775 163.918 µM 0.216692592213664 0.429864474493824 no 1405 0.414223960703442 1863 2263357
SGTC_1878 temozolomide 1 mM 0.215878672597126 0.430138209362969 no 1406 0.414541160964585 2069 5394 DNA alkylating agent.
SGTC_250 brefeldin a 552.239 µM 0.21561564878436 0.430226675884847 no 1407 0.414643678372378 1934 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1496 4469-0713 57.4 µM 0.214308121851903 0.430666506823832 no 1408 0.415153392424797 2005 746691
SGTC_1010 4112-3296 15.2 µM 0.213734821786896 0.430859382863906 no 1409 0.415376927449495 2077 704384
SGTC_18 0111-0177 500 nM 0.213215920749416 0.431033971593396 no 1410 0.415579275406469 1927 721752
SGTC_2037 5169046 200 µM 0.212503845230869 0.431273577474195 no 1411 0.415856989113686 1968 5718022
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.211280664281557 0.431685223921179 no 1412 0.416334135018136 1917 2333 A French combination drug.
SGTC_1183 1254-0324 198 µM 0.209764530351513 0.432195563009986 no 1413 0.416925728906402 1997 5799357
SGTC_3208 9114115 49.47 µM 0.208805086816201 0.432518575540884 no 1414 0.417300200081233 1811 650895
SGTC_2794 7785382 27.27 µM 0.208089470697492 0.43275952891926 no 1415 0.417579554191227 2089 2205081
SGTC_1615 st002656 86.5 µM 0.207859421492827 0.432836993547825 no 1416 0.417669367035668 1989 1584458
SGTC_2560 caryophyllene 100 µM 0.205684427207867 0.433569508040291 no 1417 0.418518711878952 1955 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_738 1315-0003 72.4 µM 0.205141293485271 0.433752465301426 no 1418 0.418730867441106 2036 6251474
SGTC_1253 0550-0034 176 µM 0.204316633295037 0.43403028326142 no 1419 0.419053036319873 1942 5969915
SGTC_1597 7-benzyloxygramine 47.5 µM 0.202752396942785 0.43455734483631 no 1420 0.419664283391326 1892 260807
SGTC_1426 4048-4480 71.7 µM 0.202182585980954 0.434749368731663 no 1421 0.419886993189656 2024 14224343
SGTC_3330 9141424 71.43 µM 0.20128391208405 0.435052249316821 no 1422 0.420238290713775 2047 27261020
SGTC_783 0848-0141 92.7 µM 0.201200384559064 0.435080402585606 no 1423 0.420270945403558 1925 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3109 9122853 49.47 µM 0.19772104504198 0.43625341785185 no 1424 0.421631661599655 2008 1234709
SGTC_3169 9102970 49.47 µM 0.196640682990896 0.436617762839994 no 1425 0.422054365853027 2022 17027839
SGTC_2432 5630864 12.22 µM 0.195441767210114 0.437022152233616 no 1426 0.422523560749473 1939 5714970
SGTC_1472 k841-0093 193 µM 0.19484440144311 0.437223665856769 no 1427 0.422757380528061 2043 X1472
SGTC_832 4083-0019 164 µM 0.194266844690803 0.437418512651287 no 1428 0.422983472578269 2038 1990758
SGTC_660 4031-1742 102 µM 0.193705315508119 0.437607966875388 no 1429 0.423203314752724 1940 6738706
SGTC_3192 9110362 49.47 µM 0.192033090761564 0.43817224302867 no 1430 0.423858142547457 2000 16649480
SGTC_330 1488-0319 80.1 µM 0.191275961140345 0.438427770554863 no 1431 0.424154696801725 1958 6846614
SGTC_679 0422-0091 41.4 µM 0.190804139137665 0.438587021151639 no 1432 0.424339522851077 1906 627384 YHR062C RPP1
SGTC_1135 dihydrocapsaicin 536.708 nM 0.190599297624553 0.438656162892176 no 1433 0.424419770259347 1865 107982 A Capsaicinoid.
SGTC_929 2805-0021 398 µM 0.189400543498752 0.439060825114157 no 1434 0.424889449263797 1970 3098024
SGTC_2808 7946468 45.46 µM 0.187772446713791 0.43961052203203 no 1435 0.425527517941099 1985 2970879
SGTC_800 3448-7362 155 µM 0.186706079164893 0.439970624593582 no 1436 0.425945544717216 2111 15991913
SGTC_518 1021-0119 62.6 µM 0.18639358396563 0.440076160785203 no 1437 0.426068061760571 1890 1097762
SGTC_1874 staurosporine 7.6 µM 0.185204453857545 0.440477793860182 no 1438 0.42653433792652 2054 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_42 0133-0086 60.653 µM 0.18462317300848 0.440674145920474 no 1439 0.426762304480051 1984 162923 Model of phenazepam hydroxylation.
SGTC_584 0986-0246 15.4 µM 0.183604830613213 0.441018169038598 no 1440 0.427161736634214 2093 53315 YDR232W HEM1
SGTC_349 k015-0014 24 µM 0.181546806156007 0.441713560001033 no 1441 0.42796919874451 1921 2196908
SGTC_1644 st010134 20.9 µM 0.181188983864134 0.441834483855365 no 1442 0.428109620548233 2108 3818134
SGTC_1193 1488-0126 41.5 µM 0.18118402799295 0.441836158699797 no 1443 0.428111565466907 2004 1384710
SGTC_1065 prochlorperazine maleate 2.48 µM 0.180669005423478 0.442010217047867 no 1444 0.428313694238575 2039 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.179524227807976 0.442397149082927 no 1445 0.428763047653223 2036 688761
SGTC_1904 st060225 78 µM 0.179223467073813 0.442498814606668 no 1446 0.428881118993466 2058 66595
SGTC_630 4356-0227 183 µM 0.177773001235385 0.44298916559929 no 1447 0.429450625736923 2046 779312
SGTC_682 0kpi-0099 17 µM 0.177537283889325 0.443068861532565 no 1448 0.429543191022978 1955 1714895 YML126C ERG13
SGTC_1610 st001799 48.1 µM 0.177268234373992 0.44315982987262 no 1449 0.429648850456346 1917 621897
SGTC_1221 2958-7315 257 µM 0.177103076055791 0.443215673041114 no 1450 0.429713712888948 2018 4562705
SGTC_1298 1079-1278 263 µM 0.176568854069835 0.443396311373643 no 1451 0.429923530247817 1977 2840950
SGTC_984 1492-0255 2.91 µM 0.174136122781869 0.444219047439224 no 1452 0.430879242496021 2005 1585198
SGTC_1176 0848-0131 83.3 µM 0.174011856261865 0.444261080163142 no 1453 0.430928072218916 2129 6769040
SGTC_14 0354-0009 295 µM 0.17371331547397 0.444362063121399 no 1454 0.43104538619892 2027 1713507
SGTC_2079 5212404 121 µM 0.173679692607069 0.44437343645562 no 1455 0.431058598953604 2120 758462
SGTC_1736 st036774 51 µM 0.171382833816849 0.44515048417925 no 1456 0.431961375855982 2136 1272247
SGTC_2142 5622915 118.518 µM 0.171101988220541 0.445245511260958 no 1457 0.432071786276808 1978 5322196
SGTC_1866 st057638 64 µM 0.171000928708404 0.44527970658718 no 1458 0.432111517674066 1990 688802
SGTC_940 3232-1287 54.8 µM 0.169878816735851 0.445659420907966 no 1459 0.432552720379405 2135 1585493 YIL048W NEO1
SGTC_2786 7743617 45.45 µM 0.168583855274443 0.446097688146065 no 1460 0.433061990207662 1940 583674
SGTC_81 0411-0046 9.971 µM 0.167963462688037 0.446307677411633 no 1461 0.433306011606252 2041 12925265
SGTC_329 k048-0121 21.3 µM 0.165210907791854 0.447239537613481 no 1462 0.434388990033364 2019 6832902
SGTC_3079 9117512 49.47 µM 0.164059019958378 0.44762958878389 no 1463 0.434842340982224 2113 7185044
SGTC_1425 4048-4433 7.33 µM 0.163881019603342 0.44768986762362 no 1464 0.434912404619057 2105 23734946
SGTC_588 3970-1144 52.9 µM 0.163053039131971 0.447970274507247 no 1465 0.435238337108706 2107 1888707
SGTC_384 k007-0144 5.16 µM 0.162393165678399 0.448193768281129 no 1466 0.435498126202659 2024 6824886
SGTC_168 3970-0862 530.542 µM 0.157285811248078 0.449924138589525 no 1467 0.437509801030495 2044 3135186
SGTC_2908 7930301 100 µM 0.157227287583285 0.449943971973957 no 1468 0.437532861684013 2096 2223178
SGTC_2099 5377090 177.372 µM 0.156787327201233 0.450093076400237 no 1469 0.437706230375891 2003 2243829
SGTC_2075 5212009 200 µM 0.156679063534887 0.450129768493633 no 1470 0.437748894075225 2118 780898
SGTC_1911 st060208 74.3 µM 0.156185069179527 0.450297195598923 no 1471 0.437943572686566 2096 688783
SGTC_2222 6885208 172.143 µM 0.155558717625406 0.450509494601194 no 1472 0.438190433638084 2068 609514
SGTC_2558 carylophyllene oxide 100 µM 0.155096539731356 0.450666156773631 no 1473 0.438372605036058 2156 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_906 1165-0455 526 µM 0.154513835856585 0.450863683997677 no 1474 0.438602301393967 2075 3252859
SGTC_2235 salicylic acid 500 µM 0.152226759935207 0.451639083045094 no 1475 0.439504044270581 2150 338 A COX inhibitor and kinase inhibitor.
SGTC_2220 6782180 200 µM 0.151298868158368 0.451953723729868 no 1476 0.43986998104174 2133 833803
SGTC_182 3448-4371 550.524 µM 0.150854146911562 0.452104535860945 no 1477 0.440045385952563 2197 3491403
SGTC_262 fenpropimorph 62.5 µM 0.148770280321622 0.452811300268018 no 1478 0.440867451246344 2125 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_992 3909-8734 162 µM 0.147702382388317 0.45317354672916 no 1479 0.44128882569379 2015 4288319
SGTC_2365 9042475 200 µM 0.147081855718065 0.453384056292467 no 1480 0.441533705577148 2021 6464479
SGTC_2293 7624732 200 µM 0.146487861174969 0.453585577279474 no 1481 0.441768135964387 2101 894453
SGTC_1587 estradiol valerate 56.1 µM 0.145998593213691 0.453751577282541 no 1482 0.441961249490418 2149 13791 A steroid.
SGTC_2596 sinensetin 100 µM 0.145358311524305 0.453968825785715 no 1483 0.442213988800739 2041 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2849 9019321 12.99 µM 0.145087682664962 0.454060654693954 no 1484 0.442320821597362 2064 16489627
SGTC_818 4072-2707 53.5 µM 0.144652791031115 0.454208225856907 no 1485 0.442492507154716 2109 882871
SGTC_3161 9100388 49.47 µM 0.143232390630446 0.454690252249744 no 1486 0.443053324762529 2074 25236368
SGTC_302 1094-0063 18.9 µM 0.142310498458514 0.455003140885563 no 1487 0.443417377178048 2044 5440289
SGTC_1238 0333-0287 48.8 µM 0.141849376617723 0.45515965534083 no 1488 0.443599490730773 2072 7226
SGTC_782 0083-0095 30.5 µM 0.140131148188708 0.455742919321141 no 1489 0.444278185349621 2198 3591729 An indicator and reagent.
SGTC_2357 9067248 200 µM 0.139933143137792 0.455810139596306 no 1490 0.444356407237484 2060 9150235
SGTC_2390 9097792 176.6 µM 0.139336199048474 0.456012802407322 no 1491 0.444592243081742 1990 4497149
SGTC_3012 9080433 71.4286 µM 0.139044855807904 0.456111717739567 no 1492 0.444707351742086 2160 17688859
SGTC_952 1185-0122 232 µM 0.138710253513285 0.456225323514982 no 1493 0.444839557650703 2136 678600
SGTC_3156 9099931 49.47 µM 0.138675128518728 0.456237249529261 no 1494 0.444853436368987 2070 18111053
SGTC_2863 9028737 58.44 µM 0.136532594185949 0.456964779872529 no 1495 0.445700129681902 2180 6460917
SGTC_3324 9138759 60.749 µM 0.134807779045284 0.457550572201542 no 1496 0.446381927598692 2103 45595710
SGTC_409 arachidonic acid 100 µM 0.133730101152938 0.457916626695654 no 1497 0.446808000836314 2130 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1635 st007035 42.4 µM 0.132090715206817 0.458473544735357 no 1498 0.447456269876784 2156 3716403
SGTC_2860 9025725 38.96 µM 0.131649246441865 0.458623530670991 no 1499 0.447630865728245 1983 40546248
SGTC_186 3455-3465 67.277 µM 0.130428325522752 0.459038360651613 no 1500 0.448113778735746 2144 755278
SGTC_1562 morin hydrate 59.1 µM 0.129876643864338 0.459225819139169 no 1501 0.448332011625425 2080 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3143 9086658 49.47 µM 0.129771424623693 0.459261573107165 no 1502 0.448373635774516 2013 25236626
SGTC_1759 st043059 70 µM 0.128730368034173 0.459615346499508 no 1503 0.448785502556828 2051 669426
SGTC_558 k064-0027 21.3 µM 0.12776366713388 0.459943880871666 no 1504 0.44916800189405 2125 5088526
SGTC_224 benfluorex 43.875 µM 0.127473550450531 0.460042482693992 no 1505 0.449282803033244 2183 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_973 1325-0077 65.9 µM 0.126874899243787 0.460245953761745 no 1506 0.449519706784619 2129 2835149
SGTC_640 3381-0960 37.1 µM 0.12679581243595 0.460272834763224 no 1507 0.449551005089702 2169 1745025
SGTC_1343 1487-0095 224 µM 0.124071348105497 0.461198969398165 no 1508 0.450629391871281 2194 4560101 YGL055W OLE1
SGTC_1479 0549-0158 134 µM 0.123526734858275 0.461384126676095 no 1509 0.450845002526255 2125 5440202
SGTC_2638 epoxomicin 18 µM 0.123394285124192 0.461429158122454 no 1510 0.450897441150586 2182 9915668 A protesome inhibitor.
SGTC_140 0062-0056 502.533 µM 0.123115254849088 0.461524026951027 no 1511 0.451007915778537 2175 3758964
SGTC_971 1315-0384 26.7 µM 0.121492718978205 0.462075723838996 no 1512 0.451650390699748 2053 6769120
SGTC_74 000s-0487 160.283 µM 0.12099115561386 0.462246280922065 no 1513 0.451849020263605 2216 677548
SGTC_2828 7998861 71.43 µM 0.120977366810313 0.462250969915578 no 1514 0.451854481088166 2200 2988188
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.119981952156035 0.462589482491039 no 1515 0.452248722381016 2188 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1659 st012954 42.1 µM 0.119249348017045 0.462838637912694 no 1516 0.452538905739245 2146 24207262
SGTC_2300 7976697 71.57 µM 0.118823950098632 0.462983320557157 no 1517 0.452707416836543 2075 2236109
SGTC_497 capsazepine 133 µM 0.11863303400909 0.463048254872147 no 1518 0.452783046399234 2097 2733484 A calcium channel blocker.
SGTC_484 loperamide 105 µM 0.118314570032953 0.46315657292082 no 1519 0.452909206634265 2202 3955 An opioid-receptor agonist.
SGTC_1706 st031321 9.9705 µM 0.117690716984276 0.463368769806053 no 1520 0.453156361216675 2194 6103185
SGTC_787 4152-0075 138 µM 0.117445999394943 0.463452010703832 no 1521 0.453253317011772 2056 9566539
SGTC_178 4092-0806 87.505 µM 0.116483533419949 0.463779409818303 no 1522 0.45363466784186 2206 2169044
SGTC_1594 piperine 70.1 µM 0.115896569182377 0.463979087708398 no 1523 0.453867257384968 2126 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1338 1486-1223 76 µM 0.114189315373186 0.464559925491353 no 1524 0.454543860802043 2170 3444526
SGTC_2063 5246145 200 µM 0.113802279559475 0.464691612431253 no 1525 0.454697265754092 2154 711240
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.113005613953531 0.464962685953306 no 1526 0.455013052217964 2064 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_888 0916-0002 6.97 µM 0.11220842521537 0.465233953753463 no 1527 0.455329074502479 2186 2802138 YIL048W NEO1
SGTC_2735 sertaconazole 140 nM 0.111577505908743 0.465448654764463 no 1528 0.455579204157918 2233 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1312 1218-2183 165 µM 0.110334020312008 0.465871840666843 no 1529 0.456072238826289 2213 6744073
SGTC_1518 st038567 90.8 µM 0.109517739997537 0.466149660089206 no 1530 0.456395925958655 2214 77966
SGTC_58 0957-0393 9 µM 0.10910440461545 0.466290344284937 no 1531 0.456559840684966 2174 6997992
SGTC_2891 9063876 19.48 µM 0.108973343296464 0.466334953628701 no 1532 0.456611816682473 2249 6472478
SGTC_441 propafenone 146 µM 0.108967770683893 0.466336850388331 no 1533 0.456614026672854 2197 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3031 9088762 49.47 µM 0.108374898472913 0.466538651671546 no 1534 0.456849155979249 2215 205253
SGTC_2966 9084041 48.03 µM 0.107880383245466 0.466706980880044 no 1535 0.457045289098311 2112 17741380
SGTC_130 0136-0219 337.655 µM 0.106294139011294 0.467246966347269 no 1536 0.457674490819407 2243 234244
SGTC_3011 9081274 71.4286 µM 0.103956458677153 0.468042863493319 no 1537 0.458601951113413 2117 6625322
SGTC_3141 9094609 49.47 µM 0.103948434047052 0.468045595816773 no 1538 0.45860513522714 2033 25236309 YDL196W YDL196W
SGTC_353 1988-1175 58.3 µM 0.103305388281936 0.468264552726259 no 1539 0.458860299635855 2119 2788357
SGTC_587 k089-0003 57 µM 0.103258352367113 0.468280568820164 no 1540 0.458878964434965 2230 9659696
SGTC_293 4049-0273 38.5 µM 0.102657486519732 0.468485172810859 no 1541 0.459117408076668 2174 1380311
SGTC_512 prima-1 270 µM 0.102488497429219 0.468542717677203 no 1542 0.459184471246997 2195 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.100178767619965 0.469329301831116 no 1543 0.460101201095481 2230 165521
SGTC_1609 st001574 46.4 µM 0.0993369996446577 0.469615997908424 no 1544 0.460435351108324 2217 3960012
SGTC_2477 5967686 25.23 µM 0.0985856789860344 0.469871902024175 no 1545 0.460733620568386 2168 776118
SGTC_396 dithiazanine 1.25 µM 0.0967118882698702 0.470510179857611 no 1546 0.461477599307807 2086 10578 An antihelmenthic.
SGTC_506 n9-isopropylolomoucine 153 µM 0.0957418494491109 0.470840638452159 no 1547 0.461862801247286 2255 6610355
SGTC_2135 5326629 150.42 µM 0.0956460528197907 0.470873274135583 no 1548 0.461900843988639 2141 5020077
SGTC_1872 amphotericin b 148 nM 0.094367810334073 0.471308760252351 no 1549 0.462408492649679 2210 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_811 0416-0114 265 µM 0.0925499990115181 0.471928131751187 no 1550 0.463130534089602 2111 6612453
SGTC_2830 7992007 71.43 µM 0.0922460584557729 0.472031698184044 no 1551 0.463251272330883 2186 1952075
SGTC_2059 5238311 157 µM 0.0916200985755416 0.472244997262324 no 1552 0.463499941129519 2177 703021
SGTC_3240 9133527 49.47 µM 0.0905276635815874 0.472617269189 no 1553 0.46393395592074 2210 17617455
SGTC_3072 9116419 49.47 µM 0.0896137097363193 0.472928738019578 no 1554 0.464297094724483 2159 17170162
SGTC_154 3389-1638 511.116 µM 0.0892431568866161 0.473055024465515 no 1555 0.464444333974902 1992 5238686
SGTC_895 0964-0006 13.7 µM 0.0883181585950689 0.473370280753687 no 1556 0.464811903439228 2237 6738897
SGTC_2878 9043973 25.97 µM 0.0880748449415542 0.473453209263253 no 1557 0.4649085947479 2229 6465167
SGTC_1305 1181-0477 144 µM 0.0876998238741437 0.473581029817753 no 1558 0.465057629806868 2242 6252086
SGTC_2031 5180455 200 µM 0.0873363029580171 0.473704933306902 no 1559 0.465202099332765 2244 29949
SGTC_1665 st014639 11.4 µM 0.0872801216858666 0.473724082516607 no 1560 0.465224427155796 2253 981133 YIL048W NEO1
SGTC_740 k014-0057 261 µM 0.0864754594238714 0.473998355755624 no 1561 0.465544231762049 2231 4012779
SGTC_2606 farnesol 9.78 µM 0.0836000068651315 0.47497856824618 no 1562 0.466687230739673 2242 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2403 6032726 181.2 µM 0.0827415089894419 0.475271251059757 no 1563 0.467028539305997 2189 2881040
SGTC_387 norethindrone acetate 66.7 µM 0.0806546474887238 0.475982768252512 no 1564 0.46785830265676 2171 541197
SGTC_2445 5742597 35.57 µM 0.0800362565412934 0.476193623981171 no 1565 0.46810420995134 2186 1774255
SGTC_540 1187-0821 17.3 µM 0.0798629487276185 0.476252718776489 no 1566 0.468173129149645 2105 847520
SGTC_2097 5376186 200 µM 0.079237637206942 0.476465942903116 no 1567 0.468421804264447 2250 742755
SGTC_575 k072-0246 11.9 µM 0.0783091037602163 0.476782574676918 no 1568 0.468791087974892 2256 6796779
SGTC_1042 0350-0096 82 µM 0.0767559814282867 0.477312225183702 no 1569 0.469408834556182 2137 3122515
SGTC_2924 9010168 62.78 µM 0.0764384503677504 0.477420515557992 no 1570 0.469535140051429 2186 2993929
SGTC_1669 st015249 58.4 µM 0.0762041450706859 0.477500423797121 no 1571 0.469628342495714 2292 722793
SGTC_2023 5144124 124 µM 0.0754083605006731 0.47777182748477 no 1572 0.469944903717014 2231 2830192
SGTC_1886 st057356 49.9 µM 0.0753505215960674 0.47779155394543 no 1573 0.469967912639524 2162 24207747
SGTC_3091 9116372 49.47 µM 0.0752332786191594 0.477831540847671 no 1574 0.470014553432232 2195 17169793
SGTC_1855 st056195 39.6 µM 0.0747980342783792 0.477979987277992 no 1575 0.47018770292838 2287 4028379
SGTC_345 1362-0200 395 µM 0.0746043407101528 0.478046050277942 no 1576 0.470264760181808 2164 1419823
SGTC_1431 4049-0260 9.09 µM 0.073733709131309 0.478343003720371 no 1577 0.470611137887368 2255 3854841
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0728732623871463 0.47863649515168 no 1578 0.470953485441067 2265 551469
SGTC_2747 doxorubicin 7.63 µM 0.0728710032305721 0.47863726574705 no 1579 0.470954384324279 2294 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1624 st003710 6.25 µM 0.0727850651198665 0.478666579184121 no 1580 0.470988577869822 2263 24207033
SGTC_2264 7948757 110.76 µM 0.0720304539707211 0.478923981524076 no 1581 0.471288836013535 2278 2971411
SGTC_1372 2752-0194 270 µM 0.0708930197172772 0.47931198367299 no 1582 0.471741449428813 2284 823334
SGTC_1191 1487-1166 10.6 µM 0.0700979299839878 0.479583216749553 no 1583 0.472057857142439 2225 3955771
SGTC_2663 amphotericin b 100 µM 0.0695524041594131 0.479769320274334 no 1584 0.472274960560891 2259 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_175 3793-3120 23.7 µM 0.0690969629254144 0.479924695251689 no 1585 0.472456219243462 2227 5322297
SGTC_3287 9117173 37.0625 µM 0.0681735487898058 0.480239729755021 no 1586 0.472823741489564 2301 2789709
SGTC_141 0443-0274 32.331 µM 0.0678601958263203 0.480346636927616 no 1587 0.472948462403088 2282 1627241
SGTC_1746 st038117 42 µM 0.067381235158835 0.480510047496177 no 1588 0.473139103704046 2208 2898218
SGTC_564 3555-0129 330 µM 0.0670114582978368 0.480636209256353 no 1589 0.473286290651761 2293 563260
SGTC_3074 9116018 49.47 µM 0.0660634904808643 0.48095964905501 no 1590 0.473663638850438 2267 17027303
SGTC_1708 st033234 31.827 µM 0.0658984802515072 0.481015950644875 no 1591 0.473729325269224 2269 674664
SGTC_2447 5741742 33.78 µM 0.0632546155856492 0.481918089739339 no 1592 0.474781877432642 2240 1776504
SGTC_421 streptovitacin 30 mM 0.0631356385769082 0.481958689267807 no 1593 0.474829247707759 2182 91467 include heat shock
SGTC_2345 9052315 157.45 µM 0.0625003270555571 0.482175485134916 no 1594 0.475082200749052 2226 6469265
SGTC_1966 st070145 16.1 µM 0.06194104122681 0.482366342100438 no 1595 0.47530489202758 2292 3748532
SGTC_2870 9038528 12.99 µM 0.0599930829540892 0.483031116484287 no 1596 0.476080571885898 2191 6463316
SGTC_1581 himbacine 57.9 µM 0.0599180300706411 0.483056730531944 no 1597 0.476110459887328 2200 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3046 9092212 49.47 µM 0.059279330004478 0.483274708906053 no 1598 0.476364812212458 2296 25236637
SGTC_1318 1280-3875 124 µM 0.0581786276070374 0.483650373166848 no 1599 0.476803172290288 2259 373245
SGTC_1131 3454-3128 32.3 µM 0.0577548777080865 0.483795000790107 no 1600 0.476971940259342 2221 710982
SGTC_820 1582-0060 59.9 µM 0.05661721250357 0.484183301204131 no 1601 0.477425061471494 2252 3848840
SGTC_2151 5563267 85.4165 µM 0.0553200797263697 0.484626048323234 no 1602 0.477941732675866 2221 5310824
SGTC_674 0498-0004 451 µM 0.0542206099903975 0.485001342470053 no 1603 0.478379700219174 2247 4231473
SGTC_1121 fusaric acid 630.51 nM 0.0540852616340661 0.485047543344391 no 1604 0.478433617286078 2210 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2339 9000433 200 µM 0.0537213818883584 0.48517175391724 no 1605 0.47857857355762 2246 2988954
SGTC_1182 1222-0449 220 µM 0.0531787658094874 0.485356978915046 no 1606 0.47879473705035 2257 658318
SGTC_1513 0337-0559 19 µM 0.0526853735482812 0.485525403834165 no 1607 0.478991296528644 2184 775073
SGTC_3341 9147222 25.867 µM 0.0518232426084214 0.485819707969896 no 1608 0.479334767754652 2251 1939759
SGTC_898 1000-0849 28.3 µM 0.0506606967326965 0.486216576428966 no 1609 0.479797947936747 2306 6751807
SGTC_1098 clofazimine 15.1 µM 0.0499736664769838 0.486451120402595 no 1610 0.480071686600516 2300 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2034 5197015 53.07 µM 0.0499205550451569 0.48646925221114 no 1611 0.480092848583227 2290 780676
SGTC_448 monastrol 171 µM 0.0498835307471823 0.486481892020278 no 1612 0.48010760076161 2271 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_804 1595-0054 20.9 µM 0.0496413103463431 0.486564584527271 no 1613 0.480204113149697 2220 761523 Stimulates phospholipase C.
SGTC_102 gallobenzophenone 83.616 µM 0.0489130091341899 0.486813225402652 no 1614 0.480494310741233 2321 70837
SGTC_605 1315-0399 119 µM 0.0482425866036337 0.487042111121704 no 1615 0.480761455239261 2281 24020461
SGTC_1458 k015-0034 6.33 µM 0.0475780847752606 0.487268979694655 no 1616 0.481026249030805 2220 3598957
SGTC_274 sirtinol 40.1 µM 0.0474625306295422 0.487308431632668 no 1617 0.481072296444154 2241 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3353 9151644 39.2805 µM 0.04642867258859 0.487661411930034 no 1618 0.481484291863871 2284 4909158
SGTC_2788 5282734 71.43 µM 0.0463043398662162 0.487703862322997 no 1619 0.481533840154228 2307 743706
SGTC_2321 7390090 138.78 µM 0.0444217468693461 0.488346644796201 no 1620 0.482284113630994 2258 649046
SGTC_1554 st069299 38.7 µM 0.0434931664107572 0.488663705587898 no 1621 0.482654205893751 2281 24207999
SGTC_763 3453-1109 128 µM 0.0432827423524582 0.488735555204328 no 1622 0.482738073968665 2331 1560353
SGTC_3080 9117754 49.47 µM 0.0431072524597312 0.488795476776181 no 1623 0.482808019024106 2345 9550191
SGTC_1268 0828-0275 2.46 µM 0.0420209574794528 0.489166401165388 no 1624 0.483240995609264 2301 745337
SGTC_1164 k060-0068 93.7 µM 0.0414531065631501 0.489360302298432 no 1625 0.483467338117781 2335 5963676
SGTC_2017 5132927 60.65 µM 0.0403638734998911 0.489732244111494 no 1626 0.483901515767305 2315 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_990 3985-0011 41.3 µM 0.0400294586216307 0.489846438995992 no 1627 0.484034820262471 2295 5399565 YGL099W LSG1
SGTC_191 3914-0123 66.505 µM 0.0394234745604602 0.490053370539315 no 1628 0.4842763822312 2324 3144412
SGTC_1040 k898-0338 155 µM 0.0382902115535599 0.490440364531146 no 1629 0.484728147556646 2339 20969351
SGTC_730 1436-0052 41.2 µM 0.0376623423525843 0.490654777270103 no 1630 0.484978450565075 2348 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2480 5767542 37.17 µM 0.0373649801428401 0.4907563252355 no 1631 0.485096997479305 2323 2867358
SGTC_39 0986-0283 58.349 µM 0.0373345890850384 0.490766703689966 no 1632 0.485109113303433 2327 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2536 dehydroabietamide 32.04 µM 0.0364074770705006 0.491083312614137 no 1633 0.485478726146709 2339 3983547
SGTC_3212 9128307 49.47 µM 0.0360269438669542 0.491213266410949 no 1634 0.485630437398363 2219 27243542
SGTC_195 4234-0266 16.654 µM 0.0360164529742695 0.491216849111157 no 1635 0.485634619944576 2306 2303354
SGTC_2155 5570423 76 µM 0.033326369362241 0.492135550715492 no 1636 0.48670716286271 2300 797402
SGTC_1697 st025554 27.742 µM 0.0318251462597756 0.49264825808849 no 1637 0.487305746487662 2343 1269519
SGTC_2505 galangin 7.89 µM 0.0316481989370829 0.492708691093202 no 1638 0.487376302714353 2341 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1605 st000082 49.1 µM 0.0312429710378164 0.492847089630892 no 1639 0.487537885347253 2324 1114022
SGTC_2367 9070478 135.38 µM 0.0309657444593836 0.492941772041813 no 1640 0.487648429262778 2338 572802
SGTC_2389 9091542 195.52 µM 0.0308024492292004 0.492997543165419 no 1641 0.4877135435729 2268 3626624 YOL127W RPL25
SGTC_2409 alverine citrate 63.97 µM 0.0307941136899475 0.493000390051949 no 1642 0.487716867395185 2299 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2116 5511452 16.8835 µM 0.0307341241131076 0.493020878661096 no 1643 0.487740788451273 2325 870744
SGTC_3296 9122258 64.045 µM 0.0293760051934871 0.493484730191343 no 1644 0.488282354812955 2327 4730474
SGTC_1028 k015-0029 4.8 µM 0.028628008787497 0.493740204462694 no 1645 0.488580636726654 2361 4588309
SGTC_2313 7726885 200 µM 0.0282594243199189 0.493866093516084 no 1646 0.48872762118329 2340 726423
SGTC_2608 thymoquinone 42.66 µM 0.0279816734998331 0.493960958980892 no 1647 0.488838383926159 2358 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1675 st018485 24.5 µM 0.0266159222705092 0.494427434568144 no 1648 0.489383036811617 2256 3323024
SGTC_622 1348-1566 26.3 µM 0.0261210948948941 0.494596445951573 no 1649 0.4895803757546 2328 7340407
SGTC_944 3370-0224 231 µM 0.0254062548513478 0.494840605741861 no 1650 0.489865461034832 2351 4580514
SGTC_2113 5491891 107.031 µM 0.0245729491478666 0.495125230934761 no 1651 0.49019779811767 2347 789979
SGTC_747 3448-8087 38.7 µM 0.0242991057916999 0.495218765846484 no 1652 0.490307013198219 2346 5168703
SGTC_2998 9066762 71.4286 µM 0.0236196891733338 0.495450830929755 no 1653 0.490577983421322 2344 4945196
SGTC_3348 9149464 3.537 µM 0.0230228845790078 0.495654679891977 no 1654 0.490816009265766 2369 1951442
SGTC_2373 9071805 200 µM 0.0226790195659604 0.495772133470986 no 1655 0.490953155746256 2375 10149009
SGTC_706 4262-0057 46.9 µM 0.0223353862394862 0.495889508279204 no 1656 0.491090210889772 2369 883298
SGTC_2147 5545932 89.7195 µM 0.0221574910142052 0.495950272077703 no 1657 0.491161163257046 2342 797404
SGTC_714 4296-0578 26.1 µM 0.0215929315978215 0.496143109654154 no 1658 0.491386335993228 2356 1589775
SGTC_2667 digitoxin 100 µM 0.0214400775798565 0.496195320433231 no 1659 0.491447301809664 2368 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1514 1189-1591 158 µM 0.0194765662783085 0.49686600802131 no 1660 0.492230465449161 2362 767698 YMR146C TIF34
SGTC_2100 5377183 190 µM 0.0183014306284773 0.497267410066739 no 1661 0.492699193090995 2361 2844202
SGTC_3278 9139605 49.47 µM 0.0182674182523364 0.497279028034473 no 1662 0.492712759797892 2354 7958859
SGTC_539 4859-0462 2.54 µM 0.015909348079821 0.498084504129843 no 1663 0.493653356128841 2371 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1978 st071761 42 µM 0.0149115566810145 0.498425335001502 no 1664 0.494051370024954 2345 5147680
SGTC_2343 7990716 14.84 µM 0.0147940399454781 0.498465477071025 no 1665 0.494098247248413 2374 6456862
SGTC_2598 perillyl alcohol 100 µM 0.0146568581630175 0.49851233646454 no 1666 0.49415296892828 2364 10819 An apoptosis inducer.
SGTC_335 4077-0256 27.6 µM 0.0143056526444226 0.498632303488781 no 1667 0.494293064967724 2374 3121989
SGTC_2388 9080168 200 µM 0.013747490841351 0.498822964212622 no 1668 0.494515717403462 2380 15943073
SGTC_1733 st037357 54.9 µM 0.0134361636388929 0.498929309606006 no 1669 0.494639907515229 2386 1272339 YGL099W LSG1
SGTC_1201 1889-3372 45.9 µM 0.0132374443564981 0.49899718961336 no 1670 0.49471917798853 2343 5392199
SGTC_511 blebbistatin 171 µM 0.0121547996179412 0.499367007897206 no 1671 0.495151055919373 2382 3476986 A myosin inhibitor.
SGTC_2274 7947094 46.08 µM 0.0120287219477993 0.499410074538379 no 1672 0.495201349955676 2384 2971028
SGTC_2711 st079103 59.1 µM 0.0118170646087193 0.499482374197631 no 1673 0.495285783015515 2369 54693780
SGTC_1591 genipin 88.4 µM 0.0110358082687157 0.499749242309395 no 1674 0.495597438847354 2380 442424 A DNA cross-linking agent.
SGTC_2680 butyl paraben 22.24 µM 0.0108822118119454 0.499801709095958 no 1675 0.495658711288502 2388 7184 An antifungal and steroid mimetic.
SGTC_1734 st037168 69.4 µM 0.0107663504357044 0.499841286014477 no 1676 0.495704930582401 2348 708907
SGTC_1741 st038134 10.228 µM 0.0106631194671922 0.499876548531769 no 1677 0.495746111416408 2380 1272587
SGTC_2287 7945887 168.79 µM 0.0104177102016084 0.499960377531374 no 1678 0.495844010109765 2383 1245853
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0101857207763042 0.499960377531374 no 1679 0.495936555589077 2388 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_49 0717-0965 32.132 µM 0.010139065254884 0.499944440538375 no 1680 0.495955167488094 2377 5889349 YGL099W LSG1
SGTC_472 calcifediol 10 µM 0.00967513537036424 0.499785967399956 no 1681 0.496140239649813 2356 5283731 A vitamin D metabolite.
SGTC_1064 honokiol 6.76 µM 0.00886216415628508 0.499508265835048 no 1682 0.496464554300039 2367 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3032 9089427 49.47 µM 0.0088030414832238 0.499488070221342 no 1683 0.496488139914018 2365 17173707
SGTC_664 1222-0054 14.9 µM 0.0080452777880665 0.499229227138974 no 1684 0.496790433156805 2387 6813991
SGTC_519 k048-0011 62.8 µM 0.00597734099390503 0.498522846450427 no 1685 0.497615400152901 2370 6836379
SGTC_3085 9117376 49.47 µM 0.00587618486595939 0.498488292915199 no 1686 0.497655754900476 2367 16480349
SGTC_76 0433-0009 400.328 µM 0.00397350451593917 0.497838366004007 no 1687 0.498414805218598 2344 2841569
SGTC_857 0438-0306 1.35 µM 0.00364315511581456 0.497725524167394 no 1688 0.498546594605315 2385 4686136
SGTC_1732 st034308 51.822 µM 0.00303421587107864 0.497517521177219 no 1689 0.498789524858528 2397 830119
SGTC_2694 st077685 81.9 µM 0.00247798118541504 0.497327521730493 no 1690 0.4990114295468 2399 2838096
SGTC_2744 captopril 92.04 µM 0.000742398807475474 0.496734683089338 no 1691 0.499703825753985 2399 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_226 1,3-diallylurea 8.28947 mM 0.000711086191816652 0.496723987417009 no 1692 0.499716317676982 2398 74537 YKL182W FAS1
SGTC_1371 2421-0008 32.7 µM -9.24640631454214e-05 0.496449513881549 no 1693 0.499963112175846 2406 2827552
SGTC_1684 st024538 14.6195 µM -0.00220059763546589 0.495729434230777 no 1694 0.499122089269627 2408 6732859
SGTC_1211 1056-0033 32.3 µM -0.00255808797423428 0.495607326813759 no 1695 0.498979471663116 2412 6741922
SGTC_2449 5812982 45.77 µM -0.0031112648790262 0.495418379857072 no 1696 0.498758786896713 2408 776185
SGTC_3175 9106517 49.47 µM -0.00462035349509903 0.494902930388694 no 1697 0.49815675219858 2421 41468073
SGTC_2415 st077333 57.7 µM -0.00500376596411598 0.494771972036202 no 1698 0.498003794525741 2419 2766255
SGTC_1891 st059073 26.2 µM -0.00514474129685936 0.494723820646301 no 1699 0.497947554229106 2412 688754
SGTC_174 3553-0389 74.3 µM -0.00649169121913428 0.494263761790726 no 1700 0.497410208091248 2411 738071
SGTC_1210 3013-0140 750 nM -0.0077670632826039 0.493828157805751 no 1701 0.496901421216848 2421 905973
SGTC_2717 st081029 62.2815 µM -0.00975256553855253 0.493150023326455 no 1702 0.496109350939299 2426 5292846
SGTC_2963 9082507 9 µM -0.0103584496411425 0.492943091678993 no 1703 0.495867650377321 2442 16459611
SGTC_707 0865-0008 204 µM -0.0114875474792365 0.492557468456907 no 1704 0.495417232405833 2428 723043
SGTC_2630 antimycin a 100 µM -0.0134601189027528 0.491883788785569 no 1705 0.494630351611781 2425 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2327 6189656 200 µM -0.0138505649740221 0.491750444925855 no 1706 0.494474600688711 2443 5349088
SGTC_2487 5918373 44.05 µM -0.0138731139689664 0.491742744095185 no 1707 0.494465605805475 2429 2876279
SGTC_1717 st033143 58.0435 µM -0.014383998397869 0.491568269988234 no 1708 0.494261812749805 2434 674616
SGTC_1206 3978-0017 132 µM -0.014993747323472 0.491360034401105 no 1709 0.494018584367977 2486 3873677
SGTC_1634 st006576 41 µM -0.0149969847708907 0.491358928785441 no 1710 0.494017292958523 2441 3915356
SGTC_115 0527-0192 112.043 µM -0.0150900571055595 0.491327143824728 no 1711 0.493980166670318 2463 4233931
SGTC_1230 0170-0365 3.77 µM -0.0155009350013537 0.491186826336106 no 1712 0.493816269279955 2456 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2611 pyromycin 23.93 µM -0.0156538930694036 0.491134590433145 no 1713 0.493755255242696 2447 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_144 4161-2749 112.381 µM -0.016971687941922 0.490684563649341 no 1714 0.493229601133989 2428 797501 YMR168C CEP3
SGTC_670 4204-0025 119 µM -0.0185067444263207 0.490160357043468 no 1715 0.492617298606862 2462 719039
SGTC_179 1273-0063 6.77 µM -0.0185734997198663 0.490137561150071 no 1716 0.492590671674543 2441 3108139
SGTC_2913 7966556 36.57 µM -0.0186611887919855 0.490107616746185 no 1717 0.492555694858261 2436 2976516
SGTC_1129 3453-1384 223 µM -0.0188457027205863 0.49004460839769 no 1718 0.492482097393871 2511 1084452
SGTC_1108 betulinic acid 729.144 nM -0.0188561249256424 0.490041049400447 no 1719 0.492477940274315 2447 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_199 4063-0024 41.6 µM -0.0204955859185069 0.489481212752364 no 1720 0.491824016632431 2508 306215
SGTC_896 0964-0007 44.5 µM -0.0212405539448232 0.489226830802011 no 1721 0.49152688210063 2427 6756758
SGTC_1146 3579-1023 7 µM -0.0226544141694532 0.488744056417304 no 1722 0.490962969357906 2497 X1146
SGTC_314 1671-0008 2.74 µM -0.0246636956824921 0.488057999002322 no 1723 0.490161606457074 2454 3913060
SGTC_121 0557-0495 61.343 µM -0.0251967324090806 0.487876002578285 no 1724 0.489949021644998 2465 3104427
SGTC_1799 st045822 46.1415 µM -0.0252180554533328 0.487868722235768 no 1725 0.489940517683291 2447 3674992
SGTC_1081 sertraline 6 µM -0.0262721489897467 0.487508827400772 no 1726 0.48952013456379 2444 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3242 9133940 49.47 µM -0.0263114026534526 0.487495425377926 no 1727 0.48950448002927 2533 17248444
SGTC_595 3909-8003 73.7 µM -0.0265760169315458 0.487405080890993 no 1728 0.489398951109092 2470 699517
SGTC_1710 st031758 61.5 µM -0.0265938735222677 0.487398984325107 no 1729 0.489391829877013 2505 5394341
SGTC_2412 st077135 33.4 µM -0.0269344174901216 0.487282716966107 no 1730 0.48925602114049 2623 13258915
SGTC_530 4358-1714 28 µM -0.0284395611321634 0.486768849042857 no 1731 0.488655785865325 2539 1564641
SGTC_2549 cedrol 20.94 µM -0.0287067954278703 0.486677615416301 no 1732 0.488549218317477 2464 6708665 A sedative which affects the nervous system.
SGTC_1086 cerivastatin 2.18 µM -0.0300388959302943 0.486222847607305 no 1733 0.488018016344994 2466 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1319 1306-0155 43.7 µM -0.031313524984253 0.485787716828699 no 1734 0.487509752160096 2469 3122360
SGTC_2789 5281112 71.43 µM -0.0318713881686558 0.48559727970167 no 1735 0.487287307988653 2483 765948
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0325976701823751 0.485349354556971 no 1736 0.486997713884867 2508 616764
SGTC_1523 st012844 44.7 µM -0.0334986588488093 0.485041799065584 no 1737 0.486638467658368 2553 4274103
SGTC_2936 9038235 15.59 µM -0.0335159028875036 0.485035912841563 no 1738 0.486631592143032 2458 4749415
SGTC_2304 7443016 91.4 µM -0.0337843650249464 0.484944274157352 no 1739 0.486524551865739 2459 939854
SGTC_3133 9127736 49.47 µM -0.0339860720184494 0.484875422648975 no 1740 0.486444128602489 2463 27243420
SGTC_2239 6685329 187.64 µM -0.0348057170969392 0.484595646232076 no 1741 0.486117330905597 2588 805680
SGTC_2904 7225135 42.03 µM -0.0355611566741807 0.484337792336757 no 1742 0.485816140600666 2488 4446116
SGTC_150 3970-0969 77.2 µM -0.0362263736223326 0.484110739515562 no 1743 0.485550928339084 2582 6615640
SGTC_1956 st077085 54 µM -0.0376279964659542 0.483632352510734 no 1744 0.484992142885875 2501 24208685
SGTC_1692 fluoroquinolonic acid 71 µM -0.0384528429806788 0.483350835637805 no 1745 0.484663314750962 2562 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2851 9015922 71.43 µM -0.0395847095379028 0.482964547568471 no 1746 0.48421210895284 2498 2996893
SGTC_1279 0874-0590 65.2 µM -0.0396432083280427 0.48294458329248 no 1747 0.484188789616402 2528 3523074
SGTC_2379 9035213 200 µM -0.0399248597890277 0.482848462801488 no 1748 0.484076515827573 2466 646551
SGTC_24 0417-1663 219 µM -0.0399806674083922 0.48282941719641 no 1749 0.484054269570727 2500 4329390
SGTC_1212 0520-0165 585 µM -0.0417404089626416 0.482228886142484 no 1750 0.483352820161278 2534 5403258
SGTC_1552 6-methylflavone 10.6 µM -0.0439481758940743 0.481475518714862 no 1751 0.482472856781439 2496 689013
SGTC_1116 jasmonic acid 1.58368 µM -0.0442315961926614 0.481378810513646 no 1752 0.482359898285989 2536 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1926 methyl fluorone black 53.6 µM -0.0445943039348784 0.48125504958257 no 1753 0.482215341473198 2480 72721 Reacts with homocysteine.
SGTC_3232 9132874 49.47 µM -0.0448962454253204 0.481152024320008 no 1754 0.482095004772665 2489 3784940
SGTC_828 2074-0507 139 µM -0.0461479869891349 0.480724931886466 no 1755 0.481596149318993 2552 X828
SGTC_3258 9138477 49.47 µM -0.0465972193882466 0.480571659802976 no 1756 0.481417124115824 2496 4970355
SGTC_1747 st037496 66.6 µM -0.0465991530897336 0.480571000056095 no 1757 0.481416353517633 2494 723305
SGTC_2804 7954240 19.48 µM -0.0466910094770605 0.480539660241335 no 1758 0.481379747965199 2534 828705
SGTC_2807 7945238 51.95 µM -0.0473242571190505 0.480323610353179 no 1759 0.481127397676573 2529 17148797
SGTC_1819 st053448 58.6 µM -0.0477194061960841 0.480188797278153 no 1760 0.480969933906271 2497 2857616
SGTC_3163 9099914 49.47 µM -0.0480259653560254 0.480084209999711 no 1761 0.48084777455867 2494 16268368
SGTC_2237 6667747 47.222 µM -0.0491654169235456 0.479695480997366 no 1762 0.480393735608932 2548 729940 YDL015C TSC13
SGTC_1022 4477-0945 21.3 µM -0.0502310063350885 0.479331967866437 no 1763 0.479969151625674 2497 4648966
SGTC_3340 9146634 11.102 µM -0.0507836419256452 0.479143449569779 no 1764 0.479748962954458 2516 4907387
SGTC_1115 galangin 695.678 nM -0.0529345005137228 0.47840978086489 no 1765 0.478892047742682 2493 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2852 9023854 51.95 µM -0.0530315161886047 0.478376690034868 no 1766 0.478853398374452 2562 19798528
SGTC_1561 5-methoxyflavone 52.9 µM -0.0538913628119765 0.47808341367625 no 1767 0.478510859072362 2487 94525
SGTC_3038 9091290 49.47 µM -0.0540370897526399 0.478033710324724 no 1768 0.478452807023738 2521 25236843
SGTC_565 1418-0001 44.5 µM -0.0542827380555505 0.477949927387002 no 1769 0.478354951155269 2562 2862145
SGTC_3315 9136395 68.55 µM -0.05575564494574 0.477447585574561 no 1770 0.47776823507449 2507 16876844
SGTC_2381 9035592 200 µM -0.0560236108400795 0.477356198376852 no 1771 0.477661498983223 2537 4749657
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0566300828853553 0.477149371308287 no 1772 0.477419935156717 2642 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1402 3909-7673 35.9 µM -0.0576535130772467 0.476800361678022 no 1773 0.477012311626553 2507 5328014
SGTC_687 k029-0044 34.9 µM -0.058277698848024 0.476587510891063 no 1774 0.476763715529681 2508 5829338
SGTC_1367 1812-0510 76.9 µM -0.0584229553319441 0.476537978585606 no 1775 0.476705865144028 2537 1142582 YDR527W RBA50
SGTC_1512 0259-0544 12.2 µM -0.0592316892558564 0.476262207832715 no 1776 0.476383784783703 2519 18476
SGTC_2101 5377231 179.231 µM -0.0592937640012465 0.4762410413895 no 1777 0.476359063991949 2555 2844213
SGTC_3191 9110352 49.47 µM -0.0598872321599949 0.476038682130659 no 1778 0.476122724451658 2516 17122424
SGTC_860 0443-0016 25.1 µM -0.0600795096900824 0.475973121151854 no 1779 0.476046154688619 2524 5337942
SGTC_20 0481-0013 4.944 µM -0.0601646140928802 0.475944103262781 no 1780 0.476012264250734 2499 182045
SGTC_2115 tiliquinol 12.7705 µM -0.0602408672886414 0.475918103461582 no 1781 0.475981898704813 2589 71208 A bioactive hydroxyquinoline.
SGTC_684 1140-0066 328 µM -0.0602996240747681 0.47589806942353 no 1782 0.475958500673889 2541 6813534
SGTC_2497 7-hydroxyflavone 100 µM -0.0614155630764429 0.475517584328292 no 1783 0.475514129106831 2586 5281894
SGTC_370 0180-0345 38.7 µM -0.0621670170969774 0.475261384803202 no 1784 0.475214914104799 2493 3989527
SGTC_1816 st051957 91.6 µM -0.0624931208763266 0.475150206681505 no 1785 0.475085069989754 2509 674121
SGTC_3228 9131799 49.47 µM -0.06302618157328 0.474968475187419 no 1786 0.474872827940799 2556 17015818
SGTC_1662 st014054 52 µM -0.0633778876673794 0.474848574103881 no 1787 0.474732797465455 2508 2838777
SGTC_1411 3909-8223 150 µM -0.0651453107976158 0.474246071771139 no 1788 0.474029152114232 2525 X1411
SGTC_3060 1327-0027 12.5 µM -0.0659110805188537 0.473985044371637 no 1789 0.473724309394747 2565 16000455 YPR107C YTH1
SGTC_2926 9010726 65.15 µM -0.0676910882236194 0.473378337709567 no 1790 0.47301577180386 2592 2994293
SGTC_1186 1319-0216 26 µM -0.06824424983842 0.473189807869277 no 1791 0.472795601388468 2617 4565136
SGTC_2882 9058044 58.44 µM -0.0686858275343423 0.473039312630572 no 1792 0.472619849774457 2575 18076804
SGTC_2732 terfenadine 20 µM -0.0689986760865173 0.47293269223267 no 1793 0.472495336659734 2526 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_727 3032-0951 202 µM -0.0694003292356571 0.472795809614869 no 1794 0.472335483430394 2577 3652836
SGTC_1153 4055-0057 267 µM -0.0707104748219327 0.472349336942938 no 1795 0.471814092002644 2529 882706
SGTC_3195 9113082 49.47 µM -0.0708183556143928 0.472312574763271 no 1796 0.47177116141764 2515 17018038
SGTC_1702 st027038 51 µM -0.0711806168974649 0.472189129915525 no 1797 0.471627003878159 2576 5521182
SGTC_2805 7950783 58.44 µM -0.0712068997329067 0.472180173830044 no 1798 0.471616545082936 2599 1178958 YDL195W SEC31
SGTC_2236 dapsone 200 µM -0.0715048046908195 0.472078661327627 no 1799 0.471498000379129 2539 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1720 st037298 9.481 µM -0.0730720915772644 0.471544631043774 no 1800 0.470874374983386 2588 597396
SGTC_631 k072-0230 41.5 µM -0.0731520107817887 0.471517401096224 no 1801 0.470842576933568 2610 5773147
SGTC_2286 7945697 125 µM -0.0737663869384336 0.471308076259465 no 1802 0.470598136733686 2588 1245733
SGTC_2251 lansoprazole 556 µM -0.0742805243158874 0.471132909986795 no 1803 0.470393586779397 2539 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2837 9008476 45.46 µM -0.0757227873078609 0.470641561830627 no 1804 0.469819823194974 2666 2992805
SGTC_1748 st037455 53.6035 µM -0.0763530487203415 0.470426859234823 no 1805 0.469569111101803 2620 580690
SGTC_1989 st071868 50.2 µM -0.0771376880449642 0.470159578832432 no 1806 0.469257005790018 2534 16414057
SGTC_1474 0330-0125 5.35 µM -0.0790029426367949 0.469524250643661 no 1807 0.468515141247854 2569 X1474
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0793132738517044 0.469418555576952 no 1808 0.468391724277881 2590 5024745
SGTC_1261 0712-0010 12.7 µM -0.0795369028841305 0.46934239156282 no 1809 0.468302790158305 2568 2840123
SGTC_390 dec-rvkr-cmk 16.7 µM -0.0804035186355601 0.469047248494075 no 1810 0.467958164250451 2600 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3044 9093193 49.47 µM -0.0811960634481949 0.468777346628897 no 1811 0.467643015047218 2634 25236277
SGTC_746 1095-0025 46.6 µM -0.0820549796032113 0.468484858147449 no 1812 0.467301496706835 2591 6749286
SGTC_2595 hexamethylquercetagetin 100 µM -0.0840450566619799 0.467807238749497 no 1813 0.46651030421543 2626 386331
SGTC_1646 st011709 75.6 µM -0.0843128414186406 0.467716065364034 no 1814 0.466403851390658 2562 5757843
SGTC_180 1486-1293 102.781 µM -0.0849202216586569 0.467509275289096 no 1815 0.466162407648836 2579 4140536
SGTC_110 0850-0284 111.64 µM -0.0853735733461919 0.467354931841418 no 1816 0.465982200928604 2534 3906265
SGTC_2028 5153890 36.43 µM -0.0858273988010108 0.467200432015494 no 1817 0.465801812872058 2559 2830968 YPR165W RHO1
SGTC_160 3453-0671 289.699 µM -0.088654108912266 0.466238222164954 no 1818 0.464678402321841 2579 5322268
SGTC_1558 st069300 45.6 µM -0.0886800261501707 0.466229400862246 no 1819 0.464668103403793 2572 24208000
SGTC_188 3229-0966 278.469 µM -0.0888658408296212 0.466166156663854 no 1820 0.464594265590289 2586 5722370
SGTC_1722 st034304 3.6505 µM -0.0915857506505821 0.465240502171477 no 1821 0.463513586598544 2590 4036148 YLR033W RSC58
SGTC_2310 7668677 200 µM -0.0920260494376663 0.46509067484886 no 1822 0.46333867147374 2660 2197143
SGTC_2016 5121758 140 µM -0.0928199059194503 0.464820549465181 no 1823 0.463023318321568 2567 2795203
SGTC_1410 3909-8106 77.9 µM -0.093146369333592 0.464709468522843 no 1824 0.462893640066949 2623 1039210
SGTC_2330 7979373 200 µM -0.0939457433397065 0.464437488823337 no 1825 0.462576128281529 2602 1863007
SGTC_883 0850-0245 24.6 µM -0.0944409333920197 0.46426901326062 no 1826 0.462379450473598 2764 6823229 YPR165W RHO1
SGTC_2331 7980721 200 µM -0.0960361959237684 0.463726310302404 no 1827 0.461745912609285 2676 2981221
SGTC_827 3253-0474 693 µM -0.0963575550339116 0.463616993146778 no 1828 0.461618300691755 2591 5402065
SGTC_322 k048-0136 19.3 µM -0.0965265613125204 0.463559503158056 no 1829 0.461551189770199 2669 6823282
SGTC_909 3448-9333 149 µM -0.0969147150625334 0.463427469794023 no 1830 0.461397061443804 2575 3344074
SGTC_2216 7189485 200 µM -0.0978718822054353 0.463101899568149 no 1831 0.461017013759121 2604 731273
SGTC_3183 9108214 49.47 µM -0.0982856154141584 0.462961180253527 no 1832 0.460852750056058 2571 4974831
SGTC_1941 st076221 61.8 µM -0.0985271388060842 0.462879035239595 no 1833 0.460756861572539 2738 2828568
SGTC_2146 5545642 200 µM -0.0986834828068515 0.462825861606069 no 1834 0.460694791827377 2585 825326
SGTC_2507 purpurin 79.67 µM -0.099749408809473 0.462463350840934 no 1835 0.460271636779746 2562 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2057 5236571 38.335 µM -0.100248367659528 0.462293670623712 no 1836 0.460073573773144 2618 54684039 YBR257W POP4
SGTC_1526 st051518 75 µM -0.100542141377427 0.462193770626097 no 1837 0.459956964166106 2663 673993
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.100780692892406 0.462112651114857 no 1838 0.459862276818456 2575 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_257 daunorubicin 18.5 µM -0.101424224229736 0.461893825968034 no 1839 0.459606853735213 2714 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2130 NSC 7 2.4545 µM -0.101535935563176 0.461855841036126 no 1840 0.459562516248203 2653 21448
SGTC_2178 5812956 200 µM -0.103895105001415 0.461053740210713 no 1841 0.458626295864523 2553 5403383
SGTC_321 4534-3890 65.3 µM -0.104319939947548 0.460909316088944 no 1842 0.458457727228435 2669 699746
SGTC_1072 oxiconazole 14.9 nM -0.106625547188887 0.460125607271634 no 1843 0.45754302519662 2599 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1815 st051655 58.2 µM -0.107090424168058 0.459967607614708 no 1844 0.457358621943429 2596 5984156
SGTC_2769 toremifene 3.73 µM -0.107218565552853 0.459924056783893 no 1845 0.457307793574292 2721 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2439 5492030 7.2 µM -0.108816128273025 0.459381140924433 no 1846 0.456674165635394 2674 5722370
SGTC_3082 9117008 49.47 µM -0.110272921572401 0.45888613015494 no 1847 0.456096465864148 2650 41448529
SGTC_2149 5554786 194.827 µM -0.110281371921088 0.458883258955713 no 1848 0.456093115099251 2608 745063 YPR165W RHO1
SGTC_1105 epirubicin 18.1 µM -0.110899862692432 0.458673118404505 no 1849 0.455847877243489 2607 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1440 4100-1550 40 µM -0.112087252989665 0.458269719011985 no 1850 0.455377112186363 2610 742806
SGTC_285 1486-1325 46 µM -0.112274394710886 0.458206144116523 no 1851 0.455302921739453 2688 22310230
SGTC_2248 tofa 1.1 µM -0.112435713271489 0.458151342600356 no 1852 0.455238969874902 2606 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2118 5526350 200 µM -0.112447393113618 0.45814737487293 no 1853 0.455234339654933 2737 743594
SGTC_1571 st070080 73.4 µM -0.113058617931647 0.457939743180264 no 1854 0.454992041339901 2715 4315245
SGTC_432 NS 1619 61.3 µM -0.113585448150405 0.45776078935035 no 1855 0.454783211690519 2760 4552 A K+/calcium channel activator.
SGTC_2256 7954252 200 µM -0.114829231553741 0.457338334706558 no 1856 0.454290239437769 2692 2972920
SGTC_1114 scopoletin 1.73284 µM -0.115109949876732 0.457242994563289 no 1857 0.45417898673476 2600 5280460 A coumarin with genotoxic properties.
SGTC_3090 9117696 49.47 µM -0.116978512434369 0.456608439096824 no 1858 0.453438540577314 2725 7923821
SGTC_129 0088-0017 176.636 µM -0.117481833027406 0.456437532527187 no 1859 0.453239119744683 2620 182446
SGTC_1353 1498-1206 8.11 µM -0.119777614169208 0.455658084191376 no 1860 0.45232965778096 2609 6756808
SGTC_1787 fluconazole 80 µM -0.119843420099211 0.455635744701344 no 1861 0.452303592762082 2646 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.120789461806878 0.455314602414701 no 1862 0.451928898623174 2613 97141
SGTC_1369 1866-0067 208 µM -0.123245323917453 0.454481074933983 no 1863 0.450956417912083 2630 3531355
SGTC_1143 3454-2408 5.08 µM -0.12466343988647 0.453999852859346 no 1864 0.450395001146619 2600 X1143
SGTC_1237 0330-0133 46.1 µM -0.124667520864501 0.453998468121383 no 1865 0.450393385674256 2646 X1237 YHR072W ERG7
SGTC_3327 9140648 26.9345 µM -0.126415292687846 0.453405474158254 no 1866 0.449701598725312 2683 8029710
SGTC_2184 6075246 200 µM -0.126744717366089 0.453293716674728 no 1867 0.449571225937249 2686 2267320
SGTC_3102 9121669 49.47 µM -0.127968735160813 0.45287850051321 no 1868 0.449086857651341 2667 41905072
SGTC_2967 9089538 49.85 µM -0.129929125533825 0.452213596647553 no 1869 0.448311250380106 2803 728216
SGTC_3131 9127911 49.47 µM -0.131199366925368 0.451782841424278 no 1870 0.447808798375079 2854 45595681
SGTC_1155 4088-0394 48.2 µM -0.131275709768239 0.451756954385698 no 1871 0.447778603140786 2619 2326248
SGTC_1036 k216-0215 33.5 µM -0.131919571996673 0.451538635786192 no 1872 0.447523953854019 2628 622330
SGTC_206 4546-0025 72.014 µM -0.133822619468738 0.450893442893074 no 1873 0.446771420163245 2667 6620745 YIL048W NEO1
SGTC_1272 0839-0021 27 µM -0.133922245541649 0.450859670082428 no 1874 0.446732029671581 2720 5027250
SGTC_3343 9148379 18.9835 µM -0.13411315141744 0.45079495480505 no 1875 0.446656550133312 2752 1955036
SGTC_318 1488-0629 67.2 µM -0.134509732412243 0.450660521800189 no 1876 0.446499757837435 2720 3662576
SGTC_1739 st037196 92.5 µM -0.135430621856239 0.450348380601555 no 1877 0.44613570720877 2714 612214
SGTC_592 k241-0073 46.5 µM -0.135612481464343 0.45028674178261 no 1878 0.44606381891597 2690 4230158
SGTC_2072 5231554 129 µM -0.135903493081206 0.450188109883255 no 1879 0.445948787009823 2736 789545
SGTC_1852 st056254 31.4 µM -0.135924374515401 0.45018103270492 no 1880 0.44594053311147 2685 442583
SGTC_1420 4'-methoxyflavone 42 µM -0.136087512507387 0.450125742188966 no 1881 0.445876049630847 2633 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2148 5546263 113.568 µM -0.136326619942088 0.450044705957852 no 1882 0.445781540330075 2643 792097
SGTC_1842 st055362 61.2 µM -0.137179450136365 0.449755689084985 no 1883 0.445444476877369 2653 676032
SGTC_1231 0242-0792 125 µM -0.138546044712583 0.449292617478786 no 1884 0.444904441022413 2641 3707635
SGTC_3290 9121031 71.43 µM -0.140203261025678 0.448731161178619 no 1885 0.444249697715108 2685 17014854
SGTC_856 0433-0016 11.3 µM -0.141433774356897 0.44831433598818 no 1886 0.443763637176465 2723 3911780
SGTC_781 4335-2806 94.4 µM -0.142289177174894 0.448024609658731 no 1887 0.443425797454409 2837 845254
SGTC_2366 9070441 60.58 µM -0.143431473947135 0.447637755136291 no 1888 0.442974713666705 2684 6837235
SGTC_104 0074-0074 590.992 µM -0.14361093800973 0.447576981679227 no 1889 0.44290385145745 2634 3943124
SGTC_87 0100-0052 35.5 µM -0.144005177208725 0.447443481396096 no 1890 0.442748190715053 2675 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_893 0958-0369 48.9 µM -0.144504748111517 0.447274321442895 no 1891 0.44255095367685 2808 6819948
SGTC_790 1575-0012 79.1 µM -0.144848688205599 0.447157865288336 no 1892 0.4424151699627 2708 378741 YLR208W SEC13
SGTC_2394 5221648 200 µM -0.145976615283629 0.446775987633627 no 1893 0.441969924479326 2775 788586
SGTC_48 0382-0018 55 µM -0.147262653061668 0.446340639314358 no 1894 0.44146235478939 2898 762596
SGTC_671 0560-0003 407 µM -0.147320870053088 0.44632093327838 no 1895 0.441439380142563 2754 3238678
SGTC_1169 aniline yellow 25.8 µM -0.147888215406235 0.44612889787532 no 1896 0.441215494340439 2710 6051 A DNA damaging agent.
SGTC_2541 muurolladie-3-one 83.07 µM -0.149157482760243 0.445699321303009 no 1897 0.440714684229488 2839 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1173 0443-0020 122 µM -0.149232445848753 0.445673952445439 no 1898 0.440685109278961 2697 5331295
SGTC_1862 st057513 3.81 µM -0.150244193130375 0.445331580767491 no 1899 0.440285980252229 2696 5393163
SGTC_1478 0453-0656 35.7 µM -0.151151034708278 0.44502474344605 no 1900 0.439928287524038 2682 5258496
SGTC_802 4112-3352 742 µM -0.15129463154863 0.444976159287468 no 1901 0.439871651970262 2822 704594
SGTC_3186 9110464 49.47 µM -0.152222141210747 0.444662368170892 no 1902 0.439505865649571 2793 17018021
SGTC_2635 hydroquinidine 100 µM -0.152819592257371 0.444460259429015 no 1903 0.439270273414063 2683 442912 An experimental heart treatment.
SGTC_80 0159-0065 512.242 µM -0.152910175816639 0.444429617626828 no 1904 0.439234555571285 2639 1548079
SGTC_3248 9135562 49.47 µM -0.153813468490544 0.444124077999535 no 1905 0.438878406948628 2712 17650701
SGTC_1951 sophoraflavanone G 9.2 µM -0.153963467192832 0.444073344002297 no 1906 0.438819270510887 2676 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_849 0386-0493 241 µM -0.154778991799601 0.443797525519352 no 1907 0.4384977768594 2689 726119
SGTC_1798 st045719 60.953 µM -0.15514806977318 0.443672708640325 no 1908 0.438352293378687 2669 3980186
SGTC_1175 0741-0056 27.6 µM -0.155546546083291 0.44353795593881 no 1909 0.438195230988503 2851 765927
SGTC_3110 9122132 49.47 µM -0.156268150445127 0.443293947677319 no 1910 0.437910830075442 2826 918317
SGTC_593 1203-0218 61.7 µM -0.156449250660811 0.443232712576592 no 1911 0.437839459334138 2804 3666956
SGTC_2605 digitonin 300 nM -0.156671387990598 0.443157603519378 no 1912 0.437751918821196 2683 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3226 9131256 49.47 µM -0.159632672469422 0.442156530372436 no 1913 0.436585220049582 2676 17178073
SGTC_2227 7312221 64.1025 µM -0.159678922386777 0.442140898329425 no 1914 0.436567002668244 2702 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2278 7948257 134.34 µM -0.160007483359222 0.442029850363674 no 1915 0.436437589651896 2781 1247028
SGTC_705 1124-0212 310 µM -0.162030609257592 0.441346169270637 no 1916 0.435640874828054 2710 9554485
SGTC_543 3844-1095 191 µM -0.162546453533066 0.44117187632069 no 1917 0.435437775004361 2799 4230703
SGTC_32 0928-0142 34.1 µM -0.162556842500244 0.441168366223733 no 1918 0.435433684802423 2700 2244242
SGTC_1670 st016595 4.04 µM -0.162733385129544 0.441108718869676 no 1919 0.435364179911576 2697 597879
SGTC_3222 9128301 49.47 µM -0.165213615952317 0.44027088061864 no 1920 0.434387924278299 2727 4911358
SGTC_2145 5634607 200 µM -0.16555488425228 0.440155618787974 no 1921 0.43425362718522 2684 308662
SGTC_3062 9077494 49.47 µM -0.165620284175976 0.440133530837166 no 1922 0.434227891644748 2798 16459633
SGTC_499 genistein 192 µM -0.166913017456586 0.439696965761892 no 1923 0.433719245194981 2761 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2086 5274770 176.623 µM -0.167286214104856 0.439570948257252 no 1924 0.433572425420856 2763 689278
SGTC_1217 1183-1422 255 µM -0.16781193123772 0.439393439472625 no 1925 0.433365617921126 2827 2849664
SGTC_1469 k284-2957 126 µM -0.167957534938403 0.439344278427081 no 1926 0.433308343313573 2731 23884841
SGTC_1981 st071826 47 µM -0.168049318986956 0.439313289312214 no 1927 0.433272239900342 2805 11838600
SGTC_2010 4012422 159 µM -0.170151136172988 0.438603753395989 no 1928 0.432445639471631 2785 952393
SGTC_2990 9074105 71.4286 µM -0.170419898360611 0.438513038263334 no 1929 0.432339962203141 2703 6502001
SGTC_307 1501-1223 22.3 µM -0.171413352009838 0.438177746550955 no 1930 0.431949378385783 2778 2830329
SGTC_1793 st048256 72.231 µM -0.171539883736484 0.438135045133139 no 1931 0.431899636247276 2677 672022
SGTC_1471 k673-0312 37 µM -0.172440189921087 0.437831234250547 no 1932 0.431545739194943 2713 24099884
SGTC_870 0573-2213 57.6 µM -0.172440236474134 0.437831218542035 no 1933 0.431545720897047 2690 3916321
SGTC_1346 1488-2224 62.4 µM -0.173257038130997 0.437555618199504 no 1934 0.431224695766155 2711 3722427
SGTC_2892 9047358 58.44 µM -0.173467401513353 0.437484643542135 no 1935 0.43114202461839 2771 6466771
SGTC_3190 9110366 49.47 µM -0.173549157128103 0.437457060497394 no 1936 0.431109896121355 2780 17123768
SGTC_1244 0416-0015 52.5 µM -0.173709082919792 0.437403104956586 no 1937 0.431047049458554 2736 96201
SGTC_1673 st016611 27.3 µM -0.173964248270979 0.437317020036616 no 1938 0.430946779749886 2922 5226799
SGTC_692 k241-0027 77.8 µM -0.17464552550187 0.437087192659018 no 1939 0.430679087053218 2865 3600480
SGTC_1148 3909-7663 27.7 µM -0.174960500611856 0.436980943669223 no 1940 0.430555335365945 2861 4084526
SGTC_667 1498-1044 59 µM -0.17604337951787 0.436615696227388 no 1941 0.430129931333783 2750 6739982
SGTC_1753 st043925 64 µM -0.177589577783574 0.436094268150759 no 1942 0.429522655079316 2796 670181
SGTC_2994 9053520 71.4286 µM -0.179019137205564 0.435612273243216 no 1943 0.428961337555412 2854 4647384
SGTC_248 streptozotocin 5.23457 mM -0.179967685500036 0.43529251034627 no 1944 0.428588968594585 2813 5300 DNA alkylating agent.
SGTC_3064 1327-0027 10 µM -0.181725907527427 0.434699912275271 no 1945 0.427898916616017 2732 16000455 YPR107C YTH1
SGTC_83 0170-0301 39.027 µM -0.184155935183723 0.43388112789836 no 1946 0.426945563414104 2719 3089716
SGTC_1232 0279-0259 161 µM -0.185709831051767 0.433357699725206 no 1947 0.426336159186591 2751 1560000
SGTC_1149 3909-7961 23.3 µM -0.186778140082177 0.432997908701838 no 1948 0.425917293487299 2740 735261
SGTC_719 2810-4230 27.3 µM -0.189691427703873 0.432017038641894 no 1949 0.42477546927564 2728 721079
SGTC_2729 fluphenazine 10.66 µM -0.19127089666212 0.431485424553451 no 1950 0.424156680612881 2750 3372 An atypical antipsychotic.
SGTC_3137 9097352 49.47 µM -0.191811022668779 0.431303658585586 no 1951 0.423945118222816 3049 44120435
SGTC_2279 7948423 32.93 µM -0.197881917310319 0.429261659526166 no 1952 0.421568726159688 2898 1247112
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.198959727617027 0.428899324660091 no 1953 0.421147123722893 2817 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1762 st045503 25.4615 µM -0.199609292260342 0.428680984982532 no 1954 0.420893079933604 2825 4645554
SGTC_1034 k072-0165 12.7 µM -0.199814393789544 0.428612048258002 no 1955 0.420812871860181 2939 5835461
SGTC_469 w7 172 µM -0.201326368769803 0.42810392532555 no 1956 0.42022169268426 2772 45115570 A P450 inhibitor.
SGTC_3113 9123498 49.47 µM -0.201699947915181 0.427978396518333 no 1957 0.420075651660222 2735 8897275
SGTC_2772 vinpocetine 57.06 µM -0.201708703417755 0.427975454611186 no 1958 0.420072229056726 2945 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2978 9011784 42.97 µM -0.202994646709547 0.427543412665769 no 1959 0.419569608207116 2902 2994934
SGTC_874 0599-0792 117 µM -0.205924953730023 0.426559234588237 no 1960 0.4184247664527 2916 765305
SGTC_3310 9130229 44.1445 µM -0.207082738872547 0.426170504470468 no 1961 0.417972621150548 2938 7761258
SGTC_2715 st079500 56.4 µM -0.207435943612909 0.426051929093531 no 1962 0.417834707035819 2744 28246688
SGTC_1190 1486-1332 13 µM -0.207478679491201 0.426037582562374 no 1963 0.417818020852895 2753 4150046
SGTC_1626 st003712 1.76 µM -0.207897233498404 0.425897078211155 no 1964 0.417654604664902 2925 24207035
SGTC_751 0833-0568 350 µM -0.208398560164078 0.425728800298159 no 1965 0.417458890236427 2849 6954252
SGTC_69 0096-0274 206.684 µM -0.208463265279325 0.425707082027938 no 1966 0.417433631300194 3059 6741392
SGTC_2880 9042983 58.44 µM -0.209002704537911 0.42552602803326 no 1967 0.417223063663554 2926 6464714
SGTC_1332 1480-0653 17.5 µM -0.209866534117015 0.425236130435789 no 1968 0.416885921224078 2814 5749438
SGTC_2919 7978188 46.38 µM -0.212281091228115 0.424426030028544 no 1969 0.415943873141906 2920 2980291
SGTC_2682 pyrogallin 40.03 µM -0.212340415837528 0.424406130219898 no 1970 0.415920733488186 2820 822798 An ATP competetive kinase inhibitor.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.212959622536804 0.424198435436327 no 1971 0.415679228391376 2741 6708630 An antioxidant.
SGTC_1664 st014217 9.02 µM -0.213365301001525 0.4240623738655 no 1972 0.415521021561041 2801 3982782
SGTC_3111 9122088 49.47 µM -0.213958111619317 0.423863565828749 no 1973 0.415289861407534 2833 16876704
SGTC_1219 1469-0211 33.1 µM -0.214476588663373 0.423689702566329 no 1974 0.415087710866498 2887 6822282
SGTC_402 epigallocatechin gallate 10 µM -0.214702254857864 0.423614033534018 no 1975 0.414999732227471 2809 65064 An antioxidant.
SGTC_501 nsc-95397 161 µM -0.219089784307624 0.422143396618314 no 1976 0.413290054205161 2974 262093
SGTC_1324 1418-0026 34.4 µM -0.221012566136409 0.421499248415068 no 1977 0.412541324274009 2896 1372513
SGTC_476 mead acid 10 µM -0.221726159249919 0.421260242018776 no 1978 0.412263532399597 2801 5312531 An omega 9 fatty acid.
SGTC_1385 3091-4834 14.1 µM -0.22205668984005 0.421149546004242 no 1979 0.412134876322834 2909 4072814
SGTC_2398 5228213 48.84 µM -0.223472687999176 0.42067539321599 no 1980 0.411583818740804 2974 80771 YMR134W ERG29
SGTC_2529 gangaleoidin 93.61 µM -0.226020448994284 0.419822555200564 no 1981 0.410592757914376 2800 4565183
SGTC_2790 5423970 71.43 µM -0.227725808767782 0.419251912775113 no 1982 0.409929703525147 2978 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_428 3448-4153 16.5 µM -0.227957025991123 0.419174556599687 no 1983 0.409839824622479 2754 3834874
SGTC_1450 4112-4260 37.6 µM -0.228568351157023 0.418970046336531 no 1984 0.409602212756183 2947 1633175
SGTC_752 1896-0090 130 µM -0.228841581471559 0.418878648041759 no 1985 0.40949602343334 2807 772567
SGTC_2111 5486399 200 µM -0.229663285590787 0.418603806131794 no 1986 0.409176713094475 2815 689674
SGTC_1263 0774-1208 64.8 µM -0.230966662498322 0.418167936833424 no 1987 0.408670350651785 2961 906585
SGTC_2555 cholic acid 100 µM -0.231797294250361 0.417890213178473 no 1988 0.408347729352308 2978 6708657 Influences liver metabolism.
SGTC_1084 voriconazole 435 nM -0.232328457509284 0.417712638962646 no 1989 0.408141455576322 2885 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2533 agelasine 13.65 µM -0.232616083828031 0.417616489051989 no 1990 0.408029768397356 2985 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_291 SEC14.278 35.5 µM -0.232649843885662 0.417605203806338 no 1991 0.408016659636221 2920 1068044
SGTC_1897 st060201 15 µM -0.2338481807309 0.417204670145135 no 1992 0.40755142179027 2848 611878
SGTC_1285 0929-0069 65.5 µM -0.234021634874863 0.417146701714629 no 1993 0.407484091382449 2848 1206237
SGTC_3123 9126162 49.47 µM -0.234449768849055 0.417003626914838 no 1994 0.407317912560704 2796 25239884
SGTC_265 mycophenolic acid 32.932 µM -0.236090535975095 0.416455413503451 no 1995 0.406681208789688 3058 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1417 3966-0327 90.4 µM -0.236313837706711 0.41638081642475 no 1996 0.406594575024157 2870 651118
SGTC_2081 5214970 32.255 µM -0.236586609465477 0.416289697275584 no 1997 0.406488754709945 2917 2063512
SGTC_185 k048-0037 25.491 µM -0.237541270289781 0.415970829181783 no 1998 0.406118453078088 2962 6827589
SGTC_131 0141-0277 33.849 µM -0.23862773475708 0.415608004400438 no 1999 0.405697128544407 3001 1547771
SGTC_1604 st002052 72.4 µM -0.238649256881221 0.415600817813229 no 2000 0.405688783492838 2952 6254834 YHR062C RPP1
SGTC_1249 0481-0015 10.2 µM -0.240878077685378 0.414856731574144 no 2001 0.404824806706431 2809 4227577
SGTC_2429 5902844 64.44 µM -0.241438212593901 0.414669779847775 no 2002 0.404607749597917 2995 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_72 0744-0168 198.391 µM -0.242454442323944 0.41433065038394 no 2003 0.404214026790029 2818 677577
SGTC_2564 betulinic acid 100 µM -0.244371915458376 0.413690938044032 no 2004 0.403471395365858 3125 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2006 4011487 200 µM -0.244465416514048 0.413659749822206 no 2005 0.403435191570729 2988 45595294
SGTC_1349 flufenamic acid 69 µM -0.244525911453253 0.4136395714142 no 2006 0.403411768250576 2810 3371 A non-steroidal anti-inflammatory.
SGTC_694 1315-0438 43.2 µM -0.246358298194037 0.413028477402189 no 2007 0.402702442375048 2879 6793154
SGTC_2607 solasodine 47.35 µM -0.246842433427418 0.412867055266804 no 2008 0.402515084630275 2863 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_637 1181-0519 7.26 µM -0.24706126391964 0.412794096838828 no 2009 0.40243040574526 2849 6252091 YGR060W ERG25
SGTC_721 1187-1332 279 µM -0.248767325886787 0.412225396593956 no 2010 0.401770383423947 2787 25730
SGTC_391 gliotoxin 8.33 µM -0.250029141908635 0.411804900162466 no 2011 0.401282406111193 3004 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2245 6637752 200 µM -0.252948945024812 0.410832273486862 no 2012 0.400153833167882 3007 681890
SGTC_63 0099-0242 26.702 µM -0.253631049152555 0.410605133939812 no 2013 0.399890303523644 3009 3898502 YLR359W ADE13
SGTC_1013 4112-3890 241 µM -0.253772008833036 0.410558198334378 no 2014 0.399835849696808 2839 705171
SGTC_2677 mitomycin C 100 µM -0.254384742544309 0.41035419015108 no 2015 0.399599168522181 2878 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_754 3474-0146 171 µM -0.255645913173032 0.409934362890154 no 2016 0.399112131259377 2839 24762078
SGTC_571 k831-0106 44.2 µM -0.256101817847335 0.409782623544721 no 2017 0.398936109172417 2919 4783639
SGTC_786 4544-0069 423 µM -0.256670165027495 0.409593478736439 no 2018 0.3987167024844 2978 748821 YLR208W SEC13
SGTC_3043 9092303 49.47 µM -0.256833291659386 0.40953919440275 no 2019 0.39865373443013 2887 25236084
SGTC_2872 9044037 25.97 µM -0.257781578492533 0.409223663390214 no 2020 0.39828774117785 2835 6465195
SGTC_1437 4092-1038 11.6 µM -0.258148899201564 0.409101457641469 no 2021 0.398145997015032 2873 3977136
SGTC_1448 4255-0083 152 µM -0.260124564052057 0.408444315731307 no 2022 0.397383845293042 3009 5399660
SGTC_2371 9071574 200 µM -0.260561427128802 0.408299041841998 no 2023 0.397215369506035 2968 45596039
SGTC_2353 9059630 146.67 µM -0.260583472868056 0.408291711113902 no 2024 0.397206868097855 2974 4779114
SGTC_223 busulfan 5 mM -0.262007105660017 0.40781838771188 no 2025 0.396657981992333 2958 2478 A DNA alkylator.
SGTC_171 k064-0041 9.68 µM -0.262155376402027 0.407769099005928 no 2026 0.396600827492867 2885 53325
SGTC_2796 7949634 45.45 µM -0.26248788665541 0.407658570031947 no 2027 0.396472661551633 2841 2971588
SGTC_962 1254-0300 21.5 µM -0.264086785336453 0.407127186567503 no 2028 0.395856523157632 2846 7340576
SGTC_3027 9089541 49.47 µM -0.26442612981904 0.407014429611095 no 2029 0.395725789580637 2965 9943819
SGTC_1921 5740136 50 µM -0.264773760691191 0.406898927254795 no 2030 0.395591875808513 3079 1774243
SGTC_3261 9137475 49.47 µM -0.265961969981643 0.406504199081207 no 2031 0.395134249003858 2879 17027690
SGTC_3086 9117350 49.47 µM -0.266544123423321 0.406310839879402 no 2032 0.394910091225918 2846 2679265
SGTC_1174 0739-0097 51.1 µM -0.266849713955417 0.406209348733342 no 2033 0.394792437719867 2925 728447
SGTC_2996 9066192 71.4286 µM -0.268079833242182 0.405800871687616 no 2034 0.394318934302205 2924 6472854
SGTC_917 harmaline 728.087 nM -0.268779399841913 0.405568617245828 no 2035 0.394049723366907 2992 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_538 2922-0838 53.3 µM -0.270800953687665 0.404897653291219 no 2036 0.393272063169562 3082 777039
SGTC_947 3447-0010 211 µM -0.270965014400734 0.404843212945545 no 2037 0.39320897020724 2859 748350
SGTC_1397 3532-0190 20.1 µM -0.271325252600181 0.404723681392996 no 2038 0.393070442951605 2831 5322280
SGTC_977 1348-1378 135 µM -0.271497241199642 0.404666616553498 no 2039 0.39300431062882 2879 X977
SGTC_526 4469-0568 170 µM -0.271648321535852 0.404616490629702 no 2040 0.392946220409859 2874 2901964
SGTC_2284 7945075 39.21 µM -0.272636084612975 0.404288806003137 no 2041 0.39256648542228 3033 1245402
SGTC_60 0986-0278 202 µM -0.273212515047773 0.404097609582078 no 2042 0.39234493010859 2881 3110598
SGTC_2165 5727197 32.143 µM -0.273611247266319 0.403965367347348 no 2043 0.392191694832512 3279 1361712
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.274258635691787 0.403750679983119 no 2044 0.391942935041179 3019 756377
SGTC_1647 st011722 22.4 µM -0.274444530033424 0.403689038937767 no 2045 0.391871513071075 3050 2854783
SGTC_389 tpck 16.7 µM -0.276948408567127 0.402859006959795 no 2046 0.390909860554559 2963 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_954 1189-0853 2.85 µM -0.277040429273544 0.402828510547723 no 2047 0.390874531272721 2846 2828194
SGTC_1859 st055998 20 µM -0.277940453725369 0.40253026630406 no 2048 0.390529034640804 3090 676301
SGTC_1674 st016616 23.6 µM -0.278905052890112 0.402210686686087 no 2049 0.390158845355037 2841 625830
SGTC_2941 9056145 11.23 µM -0.282132520617956 0.401141876471898 no 2050 0.388920948918848 2892 2119517
SGTC_2946 9065502 71.43 µM -0.283648776065471 0.400640007160436 no 2051 0.388339776850347 2932 16489101
SGTC_2363 9053361 176 µM -0.283695960722286 0.400624392015388 no 2052 0.388321695243366 3071 6469797 YMR079W SEC14
SGTC_1725 st036284 20.55 µM -0.283825993979496 0.40058136003156 no 2053 0.388271866521482 3146 707914
SGTC_3213 9129884 49.47 µM -0.2844132196645 0.400387044118688 no 2054 0.388046864655385 3015 17190742
SGTC_283 0987-0079 11.7 µM -0.285270356260957 0.400103457604248 no 2055 0.387718510978193 3001 411556
SGTC_393 acivicin 6.25 µM -0.285355914205554 0.400075153360284 no 2056 0.387685739665 2899 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1913 st060213 96.1 µM -0.288122686753621 0.399160134554227 no 2057 0.386626413559281 3092 688959
SGTC_1649 st011737 51.3 µM -0.288224744195044 0.399126392979871 no 2058 0.386587354484922 2964 1761035
SGTC_3188 9110789 49.47 µM -0.288865467004307 0.3989145785567 no 2059 0.386342165509696 3084 849217
SGTC_2499 avocadenofuran 51.48 µM -0.289357650994272 0.398751889298552 no 2060 0.386153849525165 2904 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_748 act1.228 77.9 µM -0.290235501388482 0.398461763386395 no 2061 0.385818039165497 2904 4421505 YNR035C ARC35
SGTC_84 0443-0269 128.823 µM -0.290888983359409 0.398245826730431 no 2062 0.385568113587293 2949 6150058
SGTC_1466 k213-0079 57.5 µM -0.295042086940132 0.396874205577837 no 2063 0.383980864612882 2923 3657981
SGTC_2514 salinomycin 42.74 µM -0.29589478829881 0.396592746089691 no 2064 0.383655215643736 3106 23682228 A polyether potassium ionophore.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.296177858516342 0.396499322234152 no 2065 0.38354712850989 2933 279621
SGTC_3231 9132313 49.47 µM -0.296538733478949 0.396380228493033 no 2066 0.383409345662465 2984 4905967
SGTC_2985 9022375 71.43 µM -0.299008390569735 0.395565467435692 no 2067 0.382466821761214 3123 4939335
SGTC_615 k087-0205 167 µM -0.299829762103874 0.395294590841104 no 2068 0.382153506128021 2948 9642773
SGTC_1381 2324-0066 62.1 µM -0.30055467178375 0.395055568004534 no 2069 0.381877050361727 3050 10885928
SGTC_298 1391-0729 10 µM -0.302289856963503 0.394483589837338 no 2070 0.381215554928054 2934 3237558
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.302701247347251 0.394348014378431 no 2071 0.38105877355864 3068 16725076
SGTC_1071 trifluoperazine 6.31 µM -0.303024359200795 0.394241540459007 no 2072 0.380935648930031 3087 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2417 cerulenin 830 nM -0.305306626638355 0.393489698327394 no 2073 0.380066314701412 3051 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_426 0988-0037 14.6 µM -0.30538433648519 0.393464105523259 no 2074 0.380036725025515 3147 5383008
SGTC_768 0384-0033 77.3 µM -0.306674201237873 0.393039371375556 no 2075 0.379545684286317 2964 3965305 YMR134W ERG29
SGTC_3033 9090887 49.47 µM -0.308444799408624 0.392456545935768 no 2076 0.378871948757479 2943 19325384
SGTC_358 0075-0058 9.45 µM -0.308606118790917 0.392403456615167 no 2077 0.378810582899147 2970 1069125
SGTC_324 1315-0088 19.6 µM -0.309679251601717 0.392050345523807 no 2078 0.378402441233576 3025 6787421
SGTC_1975 st070967 30.8 µM -0.309946875616798 0.391962298491009 no 2079 0.378300677634872 3119 261391
SGTC_2691 st077356 60.2 µM -0.310412219064344 0.39180921587715 no 2080 0.378123751644316 3119 2839272
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.311759694008366 0.391366035703449 no 2081 0.377611578945532 3026 1377
SGTC_53 0973-0023 39.979 µM -0.312069565818523 0.391264139780274 no 2082 0.377493827643393 2977 674768
SGTC_2316 5844804 197.44 µM -0.313919550205312 0.390655960272607 no 2083 0.376791070749264 3079 776813
SGTC_1082 camptothecin 424.86 nM -0.315859099920525 0.390018623439096 no 2084 0.376054728663174 2811 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2073 5212005 126 µM -0.316488381917312 0.389811904532524 no 2085 0.375815921108613 2914 691789
SGTC_41 0478-0632 82.643 µM -0.316579806020552 0.389781874339288 no 2086 0.375781230336944 3016 3750424
SGTC_1808 st050063 61.5 µM -0.317853940514863 0.389363426293139 no 2087 0.375297866076073 3128 4011993
SGTC_1797 st048695 56.8 µM -0.320459525375295 0.388508106465671 no 2088 0.374310003943393 3093 592262 YIL048W NEO1
SGTC_2942 9052777 62.25 µM -0.320845065709253 0.388381593225509 no 2089 0.374163902919179 2999 6469503
SGTC_2250 alverine citrate 130 µM -0.321212095415166 0.388261165162334 no 2090 0.374024833312632 2933 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1718 roemerine 11.9335 µM -0.325171821928568 0.386962603678176 no 2091 0.372525516837121 3121 235224 An aporphine alkaloid with mutagenic activity.
SGTC_654 1124-0271 80.9 µM -0.325427771239689 0.386878710440483 no 2092 0.372428669983038 2991 5403748
SGTC_643 k048-0106 28.4 µM -0.32557448099915 0.386830625345692 no 2093 0.372373161148773 3063 6763920
SGTC_613 3914-0030 117 µM -0.326720704571151 0.386455002840341 no 2094 0.37193956946997 2908 1145395
SGTC_1657 st012939 43.4 µM -0.326897486556097 0.38639708006562 no 2095 0.371872711091835 3120 24207257
SGTC_477 mead ethanolamide 10 µM -0.327863858502533 0.386080492208996 no 2096 0.371507300665523 2988 16061185
SGTC_2324 6149169 200 µM -0.328910178497669 0.385737798524925 no 2097 0.371111790326043 3042 2888231
SGTC_1668 st014914 51.6 µM -0.332638396834959 0.384517448503962 no 2098 0.369703627917166 3058 2839556
SGTC_2749 bexarotene 57.39 µM -0.332946380883576 0.384416687692641 no 2099 0.369587378960714 3073 82146 An retinoic acid receptor inhibitor.
SGTC_2406 ethylparaben 405.7 µM -0.333322366329334 0.384293689964966 no 2100 0.369445478952696 2892 8434 A possible steroid mimic.
SGTC_435 c-PAF 6.7 µM -0.334754623667673 0.383825256307738 no 2101 0.368905096264877 3147 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1358 1509-0022 2.48 µM -0.33488816089957 0.383781590298987 no 2102 0.368854726599656 3066 3258434
SGTC_3293 9120939 62.045 µM -0.336608888466313 0.383219053169922 no 2103 0.368205877416868 3154 934087
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.338220417214989 0.382692438298852 no 2104 0.367598545420533 3069 279621
SGTC_2597 laccaic acid a 100 µM -0.33823889659344 0.382686400868748 no 2105 0.367591583069228 3128 5491415 A textile dye.
SGTC_3193 9111931 49.47 µM -0.338444885747499 0.382619103721781 no 2106 0.367513976865823 2972 17087244
SGTC_1927 st060202 13.8 µM -0.339809018578442 0.382173527822426 no 2107 0.367000177900764 3075 688887
SGTC_3274 9138298 49.47 µM -0.340890670804237 0.38182033132054 no 2108 0.366592944126247 2963 17015756
SGTC_2686 alizarin 95.37 µM -0.340913219513378 0.381812969440181 no 2109 0.366584456306044 3046 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1653 st012112 65 µM -0.341232809325892 0.381708631835495 no 2110 0.36646416282888 3176 720429
SGTC_3119 9125183 49.47 µM -0.3433821919889 0.381007138953009 no 2111 0.365655477376729 3043 22695334
SGTC_249 wiskostatin 11.211 µM -0.344715748724837 0.380572103089193 no 2112 0.365154038638025 3109 2775510 A n-wasp and actin depolymerizer.
SGTC_934 2950-0684 338 µM -0.345136943758717 0.38043473125001 no 2113 0.364995710396209 3214 1121253
SGTC_981 1488-1094 54.9 µM -0.34564038291967 0.38027055545014 no 2114 0.364806496582386 2957 3449522
SGTC_659 k018-0002 107 µM -0.346132230967794 0.380110180438782 no 2115 0.364621670994396 3142 6797879 YHR007C ERG11
SGTC_1962 st076595 64.5 µM -0.346982973720346 0.37983283067713 no 2116 0.364302055034788 3017 279619
SGTC_2315 7733312 200 µM -0.348763508467158 0.379252560567854 no 2117 0.363633430631452 3012 726316
SGTC_2506 ethyl hematommate 54.16 µM -0.349333835042109 0.379066750551971 no 2118 0.363419349919506 3085 3940691 An allergen.
SGTC_453 enantio-paf c16 10 µM -0.349374083126883 0.379053638948995 no 2119 0.363404243802042 3138 13871343 A lipid and platelet activating factor
SGTC_222 nsc-310342 10.666 µM -0.350553191947238 0.378669582937985 no 2120 0.362961788990998 3113 432556
SGTC_203 k066-0004 30.888 µM -0.350693681834576 0.378623830946169 no 2121 0.362909083029067 3102 6795412
SGTC_728 3030-5151 22.5 µM -0.352034390996941 0.378187300738414 no 2122 0.362406235482058 3020 3125388
SGTC_815 1582-0027 36.9 µM -0.352273634865384 0.378109420101669 no 2123 0.362316529393644 3118 3128206
SGTC_3077 9117319 49.47 µM -0.352771279136244 0.377947438704062 no 2124 0.362129958569214 3011 17154678
SGTC_1906 st060206 94.7 µM -0.354230535180485 0.377472579974831 no 2125 0.361583060757237 3165 5133468
SGTC_230 MPP+ 141.667 µM -0.354529543809531 0.377375301956549 no 2126 0.361471033603051 3075 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_912 3474-0017 2.18 µM -0.354595597042284 0.377353813566833 no 2127 0.361446287571563 3189 3360550
SGTC_647 0140-0236 81 µM -0.355863052408526 0.376941559526679 no 2128 0.360971563376906 3068 990837
SGTC_1254 0550-0035 264 µM -0.35862487315941 0.376043732770622 no 2129 0.359937868420265 3168 15121435
SGTC_2876 9059903 25.97 µM -0.360121119174079 0.375557605200099 no 2130 0.359378280025741 3090 6916095
SGTC_337 1315-0038 354 µM -0.360985735738693 0.375276782861119 no 2131 0.359055055184677 3054 1626437
SGTC_1476 4112-3294 3.34 µM -0.362283278652115 0.374855472654924 no 2132 0.358570176203796 3169 704369
SGTC_2553 4-methylesculetin 85.09 µM -0.364406411244325 0.374166416965528 no 2133 0.357777274324474 3103 5319502
SGTC_320 4092-0846 5.34 µM -0.365337217018411 0.373864453580345 no 2134 0.357429850180694 3135 1359356
SGTC_3050 9093513 49.47 µM -0.366343292520942 0.373538158928722 no 2135 0.357054464385498 3057 25236664
SGTC_1290 0986-0249 10.2 µM -0.366946395894524 0.37334260133563 no 2136 0.356829501407381 3115 53329
SGTC_2420 aureobasidin a 50 nM -0.368049235902517 0.372985087429276 no 2137 0.356418260966535 3299 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3355 9151058 44.0485 µM -0.369046256054485 0.372661971853726 no 2138 0.356046623549774 3120 17015728
SGTC_2826 7992541 19.48 µM -0.369705430895386 0.372448394801493 no 2139 0.355800992403319 3041 2985066
SGTC_2537 larixol 68.93 µM -0.370289050560243 0.372259330862561 no 2140 0.355583565658724 3113 6708759
SGTC_2467 5474540 200 µM -0.371000366606455 0.372028941235215 no 2141 0.355318629327103 3046 5413519
SGTC_2325 6158266 200 µM -0.372176220543761 0.371648191954073 no 2142 0.354880824852823 3116 3623240
SGTC_2656 pseudo-anisatin 100 µM -0.374307460529615 0.370958402520571 no 2143 0.354087791079181 3075 6708809 A neurotoxin.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.374549260564815 0.370880168531877 no 2144 0.353997857242691 2976 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3335 9143315 29.6265 µM -0.374638899485404 0.370851167367997 no 2145 0.353964519481929 3081 4899691
SGTC_1485 3909-9022 254 µM -0.374685429836788 0.370836113545288 no 2146 0.353947214742568 3143 714516
SGTC_1295 1013-0063 9.78 µM -0.377464686309334 0.369937308502305 no 2147 0.352914151508955 3200 6826038
SGTC_927 2425-1185 123 µM -0.377496531625608 0.369927013906382 no 2148 0.35290232071278 3037 730375
SGTC_853 0419-0306 21 µM -0.377700529791267 0.369861069883425 no 2149 0.352826537095225 3056 762713
SGTC_3158 9100007 49.47 µM -0.378466812924024 0.369613396988896 no 2150 0.352541921482963 3060 19297233
SGTC_967 1306-0166 352 µM -0.378562900613506 0.369582343984811 no 2151 0.352506238071185 3215 4437607
SGTC_3314 9135860 59.4275 µM -0.380232494497737 0.369042911291776 no 2152 0.351886420153562 3208 25252478
SGTC_392 N-ethylmaleimide 8.33 µM -0.380540756725043 0.368943342347836 no 2153 0.351772024248998 3089 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_741 4582-0002 126 µM -0.380549137049603 0.36894063561912 no 2154 0.351768914503521 3053 2912688
SGTC_3269 9137823 49.47 µM -0.382054172077634 0.368454635681862 no 2155 0.3512105916634 3044 17682936
SGTC_904 1141-0088 396 µM -0.382727763891104 0.368237190186012 no 2156 0.350960813211163 3100 1378119
SGTC_1299 1079-1439 3.74 µM -0.385480570582996 0.367348982403296 no 2157 0.349940699402262 3093 323161
SGTC_1296 1068-0102 11.9 µM -0.386866020571224 0.36690222756993 no 2158 0.349427698933603 3170 767053
SGTC_629 3448-6466 76.7 µM -0.388791375126065 0.366281673407605 no 2159 0.348715240764615 3128 573744
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.388900610528524 0.366246476596981 no 2160 0.348674835258227 3185 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3039 9090270 49.47 µM -0.390692847242398 0.365669159712286 no 2161 0.348012143284217 3245 17173750
SGTC_259 usnic acid 108.925 µM -0.391972474052376 0.365257151189508 no 2162 0.347539276105449 3290 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1943 st076331 65.2 µM -0.393160458638089 0.364874788368998 no 2163 0.3471004861985 3201 24208415
SGTC_1555 citronellol 128 µM -0.393770461748093 0.364678505920308 no 2164 0.346875257128086 3175 8842 A terpine precursor.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.396519607460355 0.363794346211227 no 2165 0.34586087304339 3136 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1851 st056236 18.9 µM -0.399457444776604 0.362850302012146 no 2166 0.344778086950937 3273 5393171
SGTC_2518 prenyletin 46.28 µM -0.400249030318215 0.362596076244524 no 2167 0.344486552527979 3189 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1125 tnp00248 1.32998 µM -0.400703372312883 0.362450187030977 no 2168 0.344319263826311 3272 24207736
SGTC_2117 5521686 200 µM -0.400871981574046 0.362396051677542 no 2169 0.344257189650211 3075 803312
SGTC_3076 9116187 49.47 µM -0.40249088281428 0.36187641144809 no 2170 0.34366139840853 3204 27241210
SGTC_2761 levamisole 97.89 µM -0.403433350447863 0.361574012260461 no 2171 0.343314728248724 3263 26879 An alkaline phosphatase inhibitor.
SGTC_2572 astragaloside iv 100 µM -0.403580180931098 0.361526908161551 no 2172 0.343260731093877 3255 45006101 An anti-inflammatory agent.
SGTC_907 3448-6986 75.5 µM -0.404824493149844 0.361127809659677 no 2173 0.342803261752221 3297 590582
SGTC_360 0957-0399 1.01 µM -0.40487159778164 0.361112704369321 no 2174 0.342785948333792 3245 6752301 YPR165W RHO1
SGTC_255 tunicamycin 200.472 nM -0.408244584778538 0.36003163516739 no 2175 0.341547059307683 3171 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2821 7996764 71.43 µM -0.408324905067436 0.360005905476268 no 2176 0.341517578616795 3332 2987135
SGTC_3071 9117417 49.47 µM -0.408486208430688 0.359954235694238 no 2177 0.341458376887512 3119 45595590 YGL055W OLE1
SGTC_1123 mangostin 811.285 nM -0.409262740848797 0.359705527415414 no 2178 0.341173427758798 3166 5281650 An antioxidant.
SGTC_323 4013-0906 34.3 µM -0.409763967137676 0.359545025890387 no 2179 0.340989550486249 3215 2910086
SGTC_1882 5615643 20 µM -0.410476333621344 0.359316956170634 no 2180 0.3407282804005 3201 2253075
SGTC_2886 9058944 51.95 µM -0.411164756865491 0.359096599682289 no 2181 0.340475864400672 3139 4949929
SGTC_3323 9138564 53.9225 µM -0.411184199526775 0.359090376986701 no 2182 0.340468736627069 3275 43912313 YNL103W MET4
SGTC_443 clozapine 122 µM -0.411356553865512 0.35903521597853 no 2183 0.340405553185204 3202 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1368 1852-0141 284 µM -0.411673639015401 0.358933742389994 no 2184 0.340289324523142 3227 2838987
SGTC_204 PMA1.184 62.41 µM -0.412531909453116 0.358659128639738 no 2185 0.339974798650614 3155 2252213 YGL008C PMA1
SGTC_2620 irigenin 100 µM -0.412940017523472 0.35852857526833 no 2186 0.339825280470596 3290 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_355 1311-2252 105 µM -0.413581470066368 0.35832340864637 no 2187 0.339590323020488 3152 5338538
SGTC_2869 9037858 32.47 µM -0.413720454543598 0.358278960277375 no 2188 0.339539422652197 3079 27187042
SGTC_1403 3909-7815 62.9 µM -0.413721277656113 0.358278697045001 no 2189 0.339539121211925 3104 6615483
SGTC_1059 3448-6867 171 µM -0.413896838018691 0.358222554169045 no 2190 0.339474829840637 3212 3934407
SGTC_2813 7971799 71.43 µM -0.414720118215216 0.357959316298648 no 2191 0.339173401507728 3210 2234054
SGTC_2266 7929956 200 µM -0.416782623803514 0.357300141812983 no 2192 0.338418706619045 3163 2967153
SGTC_3000 9075062 71.4286 µM -0.417285769917102 0.357139401377609 no 2193 0.338234697869272 3132 17057871
SGTC_2126 5251174 33.877 µM -0.41985248243206 0.35631980703668 no 2194 0.337296611178427 3314 790722
SGTC_1280 0880-0253 10.1 µM -0.420547932396513 0.356097852241739 no 2195 0.337042610634113 3148 6836607
SGTC_937 3122-0005 46.7 µM -0.420891651073655 0.355988171465541 no 2196 0.336917101013368 3278 759535
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.420957242526993 0.355967242558649 no 2197 0.336893152214412 3258 688801
SGTC_1020 4335-0961 93.3 µM -0.421228316260145 0.355880753013887 no 2198 0.336794184590864 3088 669075
SGTC_2934 9036370 36.88 µM -0.422326591087514 0.355530410313785 no 2199 0.336393325807473 3209 6462800
SGTC_983 1491-0821 12.2 µM -0.42436238758131 0.354881327069211 no 2200 0.335650773388984 3253 46495113
SGTC_1995 st072814 61.1 µM -0.424990512157161 0.35468114384684 no 2201 0.335421795618717 3150 5769371
SGTC_91 0417-1751 58.384 µM -0.426185246596223 0.354300492913466 no 2202 0.334986433513979 3243 6795624
SGTC_3185 9108267 49.47 µM -0.426457183882064 0.354213872066152 no 2203 0.334887370312231 3246 4910486
SGTC_693 4161-2696 114 µM -0.426603227670494 0.354167355494504 no 2204 0.334834173208414 3251 805759
SGTC_1134 3477-0009 42.5 µM -0.426899419277078 0.354073021854392 no 2205 0.334726294267366 3351 3973534
SGTC_1937 st074714 47.2 µM -0.428752893023313 0.353482915227233 no 2206 0.334051531888236 3130 17250970
SGTC_713 1488-1073 324 µM -0.428765145530969 0.353479015458951 no 2207 0.334047073109328 3217 3312542
SGTC_1666 st014829 29 µM -0.430431029749204 0.352948935735692 no 2208 0.333441063745686 3147 3858230
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.432147653715003 0.352403009193955 no 2209 0.332817050903181 3176 6312947
SGTC_338 4055-0136 114 µM -0.432607173735501 0.352256922610232 no 2210 0.332650088466558 3144 2900563
SGTC_2719 novobiocin 32.65 µM -0.43476715257505 0.351570533378706 no 2211 0.331865724829697 3286 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1936 st074407 74.3 µM -0.436746063063297 0.350942107741493 no 2212 0.331147759602521 3155 809813
SGTC_361 000s-0510 1.45 µM -0.439995668556165 0.349911043006927 no 2213 0.329970122228992 3233 660
SGTC_2855 9016525 58.44 µM -0.440906723030194 0.349622173386897 no 2214 0.329640263159099 3176 43811474
SGTC_997 3996-0078 137 µM -0.440935532739212 0.349613040061582 no 2215 0.329629834390535 3210 735687
SGTC_550 4123-0385 25.7 µM -0.441380278189156 0.349472056804408 no 2216 0.329468858692891 3178 5731123
SGTC_1699 st031318 29.054 µM -0.443115956626826 0.348922049620334 no 2217 0.328840932072297 3275 5340658
SGTC_1239 0337-0584 35.4 µM -0.444368801337364 0.34852524137425 no 2218 0.32838798296289 3345 914301 YML130C ERO1
SGTC_148 3253-0744 288.01 µM -0.446390644318427 0.347885221133591 no 2219 0.327657544839744 3280 6893655
SGTC_146 3448-8650 53.125 µM -0.446551939051057 0.347834181452607 no 2220 0.327599301689822 3195 2891488 YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM -0.446799617257008 0.347755812180549 no 2221 0.327509873837014 3202 5370536
SGTC_3083 9117465 49.47 µM -0.44716971874704 0.3476387183824 no 2222 0.327376261702935 3260 16420915
SGTC_905 2-aminofluorene 215 µM -0.449283103389441 0.346970358281314 no 2223 0.3266137225178 3226 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3040 9091894 49.47 µM -0.452016410876473 0.346106652759932 no 2224 0.325628580013132 3163 25236966
SGTC_463 ikarugamyin 104 µM -0.453366246335157 0.345680409226455 no 2225 0.325142518751604 3258 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3303 9125618 40.5795 µM -0.453693647934842 0.345577053617703 no 2226 0.325024669732307 3247 22695467
SGTC_681 1642-0006 26.6 µM -0.453861255307097 0.345524147023122 no 2227 0.324964345815684 3286 4446530
SGTC_3068 9116768 49.47 µM -0.454685596256387 0.345263981207204 no 2228 0.324667722365658 3294 41904888
SGTC_2268 7933382 153.85 µM -0.455771360763455 0.344921420475903 no 2229 0.324277200259838 3290 935025 YOR257W CDC31
SGTC_3118 9124250 49.47 µM -0.456201243160273 0.344785826876343 no 2230 0.324122635775686 3206 1504786
SGTC_215 1287-0124 461.5 µM -0.456587109889232 0.344664133684971 no 2231 0.323983922964698 3230 5560863
SGTC_1750 st081859 2.357 µM -0.456963245271872 0.34454552499805 no 2232 0.323848731934123 3294 5291695
SGTC_362 0310-0100 9.03 µM -0.458051970737527 0.344202297820636 no 2233 0.323457551932778 3317 790235
SGTC_3140 9094243 49.47 µM -0.458918668712448 0.343929157828802 no 2234 0.323146286008916 3321 19291112
SGTC_2049 5262831 67.185 µM -0.459066534800434 0.343882565937177 no 2235 0.323093193735101 3260 763417
SGTC_412 gemfibrozil 100 µM -0.459443103544786 0.343763921648547 no 2236 0.322958000572999 3286 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2055 5235184 200 µM -0.460318741326334 0.34348809680346 no 2237 0.322643725470723 3328 2836034
SGTC_508 roscovitine 141 µM -0.461300631378507 0.343178901726414 no 2238 0.322291466016284 3267 160355 A CDKinase inhibitor.
SGTC_1683 st010134 710 nM -0.461675889706799 0.343060761391161 no 2239 0.322156881763306 3176 3818134
SGTC_700 3453-2283 142 µM -0.462783622031874 0.342712110159556 no 2240 0.321759735947592 3361 565664
SGTC_2307 7538926 6.34 µM -0.463012545134536 0.342640074856478 no 2241 0.321677687467097 3239 96582
SGTC_942 3253-1115 227 µM -0.463186878579537 0.342585221135647 no 2242 0.321615210334573 3372 46497897
SGTC_607 4491-0986 66.8 µM -0.464007231788842 0.342327142977941 no 2243 0.321321282193142 3332 698981 YDR232W HEM1
SGTC_261 5-fluorouridine 15.376 µM -0.464091933999363 0.342300500365556 no 2244 0.32129094021538 3393 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_277 nystatin 15.5 µM -0.464778863134733 0.342084459604166 no 2245 0.321044912924648 3165 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_930 2810-3379 265 µM -0.466478290746225 0.34155020801388 no 2246 0.320436591646175 3405 1015764
SGTC_577 r071-0003 38.6 µM -0.466721909313887 0.341473647260262 no 2247 0.320349426252288 3216 4568517 YMR134W ERG29
SGTC_1061 3448-9325 110 µM -0.467411554224934 0.341256951479539 no 2248 0.320102728816657 3309 723482
SGTC_1087 pterostilbene 9.05 µM -0.468953687963737 0.340772581597313 no 2249 0.319551369790445 3338 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3270 9137563 49.47 µM -0.470209493050871 0.340378338682911 no 2250 0.319102676244004 3283 17015724
SGTC_1265 0819-1001 68.8 µM -0.472024682379834 0.339808792980343 no 2251 0.318454585476698 3335 3106768
SGTC_2953 9074162 66.49 µM -0.473023532676749 0.339495542972505 no 2252 0.318098195050438 3314 16451992
SGTC_6 0844-0013 19.835 µM -0.473366892600019 0.339387887265095 no 2253 0.31797572287752 3359 1584900
SGTC_2434 5670830 169.91 µM -0.474574520899671 0.339009356446483 no 2254 0.317545135213386 3308 1549830
SGTC_3017 9080681 49.47 µM -0.475335940359908 0.338770773177668 no 2255 0.317273772971387 3295 16451914
SGTC_2708 st078559 56 µM -0.477604942475329 0.338060187598067 no 2256 0.316465706212655 3322 17250902
SGTC_2873 9040596 71.43 µM -0.477629924169335 0.338052367261378 no 2257 0.31645681426973 3341 6463863
SGTC_292 k038-0015 474 µM -0.478484268841808 0.337784962989718 no 2258 0.31615278412412 3343 46368540
SGTC_201 4262-0159 12.803 µM -0.480469384454228 0.337163951098145 no 2259 0.315446833878658 3270 1341029
SGTC_2948 9070189 9.45 µM -0.480971830396506 0.337006839123255 no 2260 0.315268259828129 3323 6473636 YDL196W YDL196W
SGTC_1575 cyproterone acetate 48 µM -0.481352281480835 0.336887893155403 no 2261 0.315133072610785 3261 9880 An androgen receptor antagonist and liver toxin.
SGTC_1473 k844-0725 134 µM -0.482222206621695 0.336615977081333 no 2262 0.314824051643071 3337 54682906
SGTC_2212 7123476 200 µM -0.482503585567327 0.336528043581596 no 2263 0.314724125953615 3283 1085715
SGTC_1877 wortmannin 25 µM -0.484348738647126 0.335951638024871 no 2264 0.314069195891788 3388 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2067 5224629 34.075 µM -0.486831823880793 0.335176558250853 no 2265 0.313188757970386 3380 2835000
SGTC_219 mitoxanthrone 164.414 µM -0.487388435509122 0.335002911453837 no 2266 0.312991543649962 3301 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3187 9109394 49.47 µM -0.487493450546355 0.334970153739915 no 2267 0.312954341532465 3270 17098090
SGTC_3345 9148410 3.559 µM -0.489244441171403 0.334424146155447 no 2268 0.312334324943491 3346 4903596
SGTC_19 0279-0214 38.434 µM -0.492804449158428 0.333315116980872 no 2269 0.31107538336412 3334 3566274 YBR002C RER2
SGTC_2965 9082772 38.63 µM -0.493088948946571 0.333226551056224 no 2270 0.310974869491993 3414 16459634
SGTC_1922 5578187 25 µM -0.493199842296202 0.333192032030256 no 2271 0.310935694652375 3440 1350412
SGTC_2935 9038016 29.96 µM -0.493863035838103 0.332985621785408 no 2272 0.310701455718756 3405 6463195
SGTC_3349 9149703 23.001 µM -0.494237223247831 0.332869183209947 no 2273 0.31056932714864 3336 4910494
SGTC_352 k048-0007 5.11 µM -0.494514813578645 0.332782813850591 no 2274 0.310471323565835 3350 6811911
SGTC_2525 harmine 47.85 µM -0.494958727834172 0.332644712964589 no 2275 0.310314627091437 3265 5280953 A monoamine oxidase inhibitor
SGTC_717 1532-0246 73.2 µM -0.498851527881207 0.33143464467267 no 2276 0.308941991963573 3330 9561992
SGTC_1990 st072050 59.8 µM -0.500435439495409 0.330942791539388 no 2277 0.308384252269944 3261 17233948
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.50267343060749 0.330248323960851 no 2278 0.307596946418513 3317 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2979 9012552 45.46 µM -0.502715629297281 0.330235234956093 no 2279 0.307582109779292 3401 17100905
SGTC_21 0849-0113 22.993 µM -0.50377645110979 0.329906262181959 no 2280 0.307209238850321 3307 1560156
SGTC_2000 st075254 36.4 µM -0.506063606807021 0.329197437163969 no 2281 0.306405998923387 3354 17234175
SGTC_1638 st008370 60.6 µM -0.506464470616173 0.329073266374024 no 2282 0.306265312767471 3368 24207134
SGTC_877 0771-0151 33.1 µM -0.507017108546319 0.328902113248831 no 2283 0.306071407177111 3328 6166523
SGTC_2730 imipramine 71.33 µM -0.508956748744525 0.328301686695723 no 2284 0.305391270508882 3405 3696 A tricyclic antidepressant.
SGTC_1845 st056753 3.01 µM -0.509483854270674 0.328138594738599 no 2285 0.305206556345331 3233 5375839
SGTC_368 fentichlor 4.58 µM -0.509949944117051 0.327994408957746 no 2286 0.305043265290597 3319 7329 A pesticide.
SGTC_686 1319-0111 510 µM -0.510488974762239 0.32782769076385 no 2287 0.304854468371663 3437 4562600
SGTC_2898 9056270 58.44 µM -0.512305875848134 0.327265989573909 no 2288 0.304218476787574 3348 19154699
SGTC_2931 9014674 55.67 µM -0.514059047676262 0.326724361048499 no 2289 0.303605354042526 3251 2996810
SGTC_2603 homopterocarpin 100 µM -0.514491804420704 0.326590720404599 no 2290 0.303454094432365 3385 101795 A weak amylase inhibitor.
SGTC_2341 7987486 176.74 µM -0.515915143705712 0.32615133261142 no 2291 0.302956838377682 3413 1258686
SGTC_3056 9094900 49.47 µM -0.517427244455605 0.325684808219678 no 2292 0.302428972609948 3310 25236784
SGTC_1204 4049-0315 18.3 µM -0.517547649076131 0.325647671824814 no 2293 0.302386957775957 3468 588402
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.518397231275581 0.325385684400407 no 2294 0.302090573032588 3400 364106
SGTC_2260 7964312 200 µM -0.51859437546287 0.325324902965214 no 2295 0.302021816077748 3429 231951
SGTC_851 0394-0702 453 µM -0.52063248788081 0.324696806001906 no 2296 0.301311406513741 3422 762646
SGTC_2359 9039622 200 µM -0.520996949725724 0.324584540129809 no 2297 0.301184448130062 3342 6463596
SGTC_2096 5468907 200 µM -0.523019344670846 0.323961867793983 no 2298 0.300480395723556 3381 759785
SGTC_3215 9129942 49.47 µM -0.523539927466013 0.323801665882547 no 2299 0.300299286623256 3386 17682944
SGTC_2069 5228469 200 µM -0.523623340414573 0.323775999773371 no 2300 0.300270272110093 3377 2835210
SGTC_988 1497-1057 103 µM -0.525253443511041 0.323274586468697 no 2301 0.299703508607212 3443 3533044
SGTC_1506 4226-2149 212 µM -0.525559930861365 0.323180347971702 no 2302 0.299597001485479 3394 991114
SGTC_976 1348-1067 47.6 µM -0.526375228939477 0.322929715989901 no 2303 0.299313761573053 3372 5310671 YGL099W LSG1
SGTC_986 1493-0483 84 µM -0.526785176049017 0.322803723911554 no 2304 0.299171389159215 3404 40079
SGTC_333 3486-0131 40.1 µM -0.528550897880918 0.322261284142955 no 2305 0.29855851510908 3474 6744690
SGTC_3284 9108171 64.8615 µM -0.530327710326842 0.321715819097902 no 2306 0.297942368670038 3365 8687505
SGTC_1654 st012436 41.8 µM -0.531353498864825 0.321401086250015 no 2307 0.297586919427023 3395 4323132
SGTC_1436 4092-1007 8.32 µM -0.53147073385198 0.321365124322801 no 2308 0.297546308287337 3338 2881121
SGTC_1521 st012942 49.4 µM -0.532927935645665 0.320918266346909 no 2309 0.297041733215342 3435 24207259
SGTC_2654 protoveratrine a 100 µM -0.534066903072117 0.320569176963666 no 2310 0.296647623614807 3353 5702278 A heart drug and vasodilator.
SGTC_1885 st057546 99.9 µM -0.53473408036447 0.320364763211348 no 2311 0.296416875817626 3484 702008
SGTC_816 0325-0417 81.3 µM -0.534815644518553 0.32033977683687 no 2312 0.296388671945806 3398 68101
SGTC_1997 st073024 93.8 µM -0.535899958926368 0.320007685229317 no 2313 0.296013846429451 3429 686268
SGTC_2740 felodipine 17.08 µM -0.536718248988655 0.319757164000315 no 2314 0.295731124285301 3375 3333 L-type calcium channel blocker
SGTC_807 1315-0151 48 µM -0.538692878309988 0.319152965762155 no 2315 0.295049394282572 3510 4011080
SGTC_183 3914-0051 30.55 µM -0.542370755438552 0.318028887419365 no 2316 0.293781560876933 3426 1596232
SGTC_1242 0402-0103 60.1 µM -0.542986013504392 0.317841007827693 no 2317 0.293569716202107 3383 432868
SGTC_44 0929-0055 61.211 µM -0.544027234200152 0.317523160078307 no 2318 0.293211365988101 3304 1379590
SGTC_1557 sumaresinolic acid 42.3 µM -0.544447502728573 0.317394905083009 no 2319 0.293066782347851 3373 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_914 3820-6779 408 µM -0.545078810315512 0.317202287669549 no 2320 0.292849657785255 3347 2893481
SGTC_698 k064-0052 127 µM -0.545676406524783 0.317020001499939 no 2321 0.292644196344726 3469 5088751
SGTC_2157 5649910 96.377 µM -0.545813754252859 0.316978112274377 no 2322 0.292596983854023 3365 2858091
SGTC_264 promethazine 12.5 mM -0.545914365314601 0.316947428730608 no 2323 0.292562401626665 3500 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1093 fluphenazine 7.97 µM -0.54720171397089 0.316554934765541 no 2324 0.292120079393781 3399 6602611 An atypical antipsychotic.
SGTC_3146 9095609 49.47 µM -0.54975069562021 0.315778396652264 no 2325 0.291245190054398 3386 17173999
SGTC_966 1300-0360 30.2 µM -0.550959373552223 0.315410460993685 no 2326 0.290830762361422 3358 70588
SGTC_532 1548-0774 215 µM -0.55217624712181 0.315040215300365 no 2327 0.290413803276283 3565 5932993
SGTC_2087 5276107 200 µM -0.552575271444435 0.314918848669804 no 2328 0.290277139414613 3422 144405
SGTC_2351 9026858 72.31 µM -0.553169911214765 0.314738021024718 no 2329 0.290073534138261 3360 1409300
SGTC_280 3448-3607 3.04 µM -0.55340580943543 0.314666297594515 no 2330 0.28999278089055 3457 626179
SGTC_176 1486-1328 72.834 µM -0.556052642410182 0.313862023881389 no 2331 0.289087434060346 3424 22310231
SGTC_822 1487-0950 154 µM -0.55662614369716 0.313687874589525 no 2332 0.288891443817255 3472 1958375
SGTC_120 rhodamine 6G 52.259 µM -0.558697399148316 0.313059263437332 no 2333 0.288184127326722 3377 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_809 3998-0021 90 µM -0.558876867486411 0.313004821622896 no 2334 0.28812287886474 3439 715485
SGTC_487 nimodipine 119 µM -0.560432742293523 0.312533017170483 no 2335 0.287592151797968 3384 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1195 1502-0147 41.1 µM -0.561897491248658 0.312089126372885 no 2336 0.287092931535309 3459 817940
SGTC_122 0236-0016 402.397 µM -0.562302518199748 0.31196643143596 no 2337 0.286954961453211 3504 6808838
SGTC_209 4077-0173 175.592 µM -0.563504226087155 0.311602520505898 no 2338 0.286545791588918 3411 15993494
SGTC_3092 9117248 49.47 µM -0.563886520965433 0.31148678941822 no 2339 0.286415681950293 3472 17141857
SGTC_2234 tolnaftate 200 µM -0.565546869383269 0.310984372865895 no 2340 0.285850927144307 3409 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2207 7258803 200 µM -0.566082103148586 0.310822487700446 no 2341 0.28566898440139 3455 3666799
SGTC_2134 5324836 1.464 µM -0.566865100348112 0.310585730725622 no 2342 0.285402918401445 3358 699272
SGTC_260 nsc-65238 3.989 µM -0.567524131173411 0.310386518581012 no 2343 0.285179068241831 3438 3246252
SGTC_2272 7805186 180 µM -0.568616779491664 0.310056354890675 no 2344 0.284808117571329 3471 2956062 YPR165W RHO1
SGTC_2305 7443522 69.23 µM -0.569448806936187 0.309805045220205 no 2345 0.284525801372875 3444 5415886
SGTC_2095 5432005 200 µM -0.569674416324725 0.309736916358335 no 2346 0.284449272630678 3409 783734
SGTC_2486 5283202 22.39 µM -0.570974957617332 0.309344310191174 no 2347 0.284008309119612 3402 1377751
SGTC_2349 9023730 187.07 µM -0.57163092104907 0.309146371082138 no 2348 0.283786021311857 3498 4126287
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.572064336063138 0.309015617070526 no 2349 0.28363919470617 3497 688798
SGTC_3182 9108849 49.47 µM -0.57217665103633 0.308981737480911 no 2350 0.283601152062902 3504 17133045
SGTC_306 1672-3436 11.6 µM -0.572317695706405 0.308939193936609 no 2351 0.283553381734512 3489 6797378
SGTC_2639 lactacystin 53 µM -0.572398313160635 0.308914878307549 no 2352 0.283526079192721 3508 3870 A proteasome inhibitor.
SGTC_327 1273-0057 3.96 µM -0.573387861435155 0.30861648155464 no 2353 0.283191053660239 3437 3108138
SGTC_1177 0983-0204 23.6 µM -0.573971058136619 0.308440678646952 no 2354 0.282993693176997 3523 766818
SGTC_946 3434-1334 87.4 µM -0.575489099422785 0.307983275622293 no 2355 0.282480280363578 3458 4047976
SGTC_225 nsc-122657 1.016 µM -0.575557898700594 0.30796255267807 no 2356 0.282457022551811 3442 275685
SGTC_2053 5265679 138 µM -0.576567328889913 0.307658573908577 no 2357 0.282115887429276 3434 764595
SGTC_2446 5162541 200 µM -0.576802919603261 0.307587647354993 no 2358 0.282036298529509 3423 1549321
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.57708399923003 0.307503035392963 no 2359 0.281941356395968 3407 6857784
SGTC_410 α-linolenic acid 100 µM -0.577401229613193 0.307407553455343 no 2360 0.281834221878581 3519 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2078 5212016 200 µM -0.577637693908562 0.307336389476873 no 2361 0.281754376313981 3435 1899708
SGTC_701 4424-0219 185 µM -0.57782488689155 0.307280058853505 no 2362 0.281691175648986 3535 2911779
SGTC_1439 4092-1168 46 µM -0.577872213477645 0.307265817928029 no 2363 0.281675198185379 3460 2886240
SGTC_2745 rifampicin 24.3 µM -0.578507805699562 0.307074591618543 no 2364 0.281460664491041 3413 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1515 3460-0031 42.1 µM -0.580577172085613 0.306452359091605 no 2365 0.280762730628275 3445 2876596
SGTC_2281 7943571 200 µM -0.58114909845193 0.306280486282631 no 2366 0.280569985117902 3546 1244024
SGTC_2001 4023502 57.655 µM -0.581150708042944 0.306280002635508 no 2367 0.280569442758297 3462 108941 YCR052W RSC6
SGTC_579 4491-1009 110 µM -0.581992280135663 0.30602717475333 no 2368 0.280285940403998 3587 1271041
SGTC_1761 st044296 37 µM -0.58208102043932 0.306000520478898 no 2369 0.280256054339446 3474 1826700
SGTC_1781 st038725 66.3 µM -0.583389765654424 0.305607541622762 no 2370 0.279815472922577 3417 4270275 YIL048W NEO1
SGTC_2138 5575593 77.673 µM -0.585351936145003 0.305018777198661 no 2371 0.279155549865435 3457 762213
SGTC_33 0986-0033 35.816 µM -0.58559475055894 0.304945953894746 no 2372 0.279073938431804 3460 2848082
SGTC_3326 9140064 16.379 µM -0.588849928409406 0.303970429189114 no 2373 0.27798097467107 3455 1868434
SGTC_2431 5490079 200 µM -0.589835425032368 0.303675366243149 no 2374 0.277650495133129 3445 5722345
SGTC_2399 5884133 200 µM -0.590235168931955 0.303555717243753 no 2375 0.277516498492776 3454 722445
SGTC_762 1165-0429 115 µM -0.592964681216522 0.302739298915622 no 2376 0.276602394583566 3501 5967793
SGTC_492 tmb-8 126 µM -0.593497427818069 0.302580065053124 no 2377 0.27642415193628 3422 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1617 st002906 78 µM -0.59426196939402 0.302351615068372 no 2378 0.276168455406718 3537 5150859
SGTC_1579 chlormadinone acetate 49.4 µM -0.594849177076656 0.302176206151727 no 2379 0.275972146032753 3530 45114258 A steroidal progestin.
SGTC_1282 0886-0010 32.4 µM -0.596242127103659 0.301760291110081 no 2380 0.275506743263308 3584 2836211 YNL267W PIK1
SGTC_901 1112-0062 60.1 µM -0.598841662982723 0.300984795847659 no 2381 0.274639238218087 3510 1908457
SGTC_2045 5106652 78.05 µM -0.602518104067512 0.299889574258165 no 2382 0.273414657966756 3509 673349
SGTC_1043 0916-0009 19.3 µM -0.602833552348213 0.299795685463641 no 2383 0.273309711841288 3560 3101130
SGTC_1791 st048313 56.1 µM -0.603107626767384 0.299714121831318 no 2384 0.273218546538647 3491 1204976
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.603327696438739 0.299648637108022 no 2385 0.273145355727957 3484 1241132 A phosphatase inhibitor.
SGTC_510 ag-490 170 µM -0.604881293952559 0.299186527568117 no 2386 0.27262893655849 3612 5328779
SGTC_3010 9080089 71.4286 µM -0.605557921218507 0.298985369439307 no 2387 0.272404175781771 3533 17027233
SGTC_3019 9081971 49.47 µM -0.605639391913056 0.298961152725662 no 2388 0.272377119208514 3569 16451803
SGTC_2393 9031399 185.94 µM -0.606684155894609 0.298650681404066 no 2389 0.272030269463782 3574 1526623 YDL150W RPC53
SGTC_2874 9043904 71.43 µM -0.606938601036582 0.29857509043732 no 2390 0.271945829845603 3445 4463428
SGTC_2171 5739187 198.077 µM -0.609244320928582 0.297890500595075 no 2391 0.271181253457838 3449 2262761
SGTC_948 3448-0295 75.3 µM -0.609617709677661 0.297779705344523 no 2392 0.27105753871165 3554 678569
SGTC_3149 9097855 49.47 µM -0.61022404650521 0.297599827712243 no 2393 0.270856701362733 3518 25236625 YMR079W SEC14
SGTC_2143 5623677 140.463 µM -0.610585543418404 0.297492608599127 no 2394 0.270736997849889 3535 5375313
SGTC_3286 9117135 37.221 µM -0.610768124095925 0.297438462315076 no 2395 0.270676549425487 3444 3438150
SGTC_2223 6903751 107.57 µM -0.611922971776291 0.29709608400144 no 2396 0.270294361102862 3511 5598863
SGTC_2868 9035608 32.47 µM -0.613910785200678 0.296507178342356 no 2397 0.269637141413004 3546 6462614
SGTC_2374 9071832 200 µM -0.614582706226093 0.296308237385147 no 2398 0.269415169082955 3518 17381698
SGTC_2334 9017922 200 µM -0.615114470339445 0.296150837191701 no 2399 0.269239563221317 3523 3163164
SGTC_2208 7283366 200 µM -0.615626380696124 0.295999349886706 no 2400 0.26907056797186 3558 898663
SGTC_793 0488-0545 106 µM -0.617040548177137 0.295581046716671 no 2401 0.268603990428717 3453 292548
SGTC_764 1951-2361 146 µM -0.617214820320044 0.295529516764821 no 2402 0.268546520818291 3461 5438930
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.617997693045077 0.295298082701538 no 2403 0.268288429661922 3565 5282362
SGTC_139 0099-0334 718.624 µM -0.618478332983043 0.295156036505205 no 2404 0.268130038012364 3582 97690
SGTC_372 0155-0182 15.9 µM -0.619121096609089 0.294966126177633 no 2405 0.267918293173781 3532 771486
SGTC_760 0568-0725 82.9 µM -0.619715691700628 0.294790497825842 no 2406 0.267722491448859 3557 3916171
SGTC_2290 7904846 200 µM -0.620224909746103 0.29464012603026 no 2407 0.267554861950316 3535 2962154
SGTC_542 3381-0244 89.3 µM -0.621058319449749 0.294394096997452 no 2408 0.26728062601752 3579 1112843
SGTC_3234 9132280 49.47 µM -0.621311589387489 0.294319348536205 no 2409 0.267197314903749 3563 17612295
SGTC_1054 3429-0080 167 µM -0.622349898357456 0.294013000360841 no 2410 0.266855908563812 3565 1162877
SGTC_2726 cimetidine 79.27 µM -0.622490118013159 0.293971640512089 no 2411 0.266809819841012 3534 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.62334434668513 0.293719731343666 no 2412 0.266529130802311 3515 688664
SGTC_1814 st052110 31.539 µM -0.623897613683347 0.29355662808645 no 2413 0.266347413790236 3557 674163
SGTC_3276 9139060 49.47 µM -0.626376274399037 0.292826433599684 no 2414 0.265534083839455 3603 4870619
SGTC_1178 0988-0033 191 µM -0.626434191882704 0.292809381637989 no 2415 0.26551509428598 3573 5392207
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.626501936874733 0.292789436863908 no 2416 0.265492883436441 3536 688662
SGTC_862 0452-0056 10.2 µM -0.628807759681327 0.292110956995723 no 2417 0.26473745965933 3520 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2383 9036125 200 µM -0.629113488211419 0.292021052471715 no 2418 0.264637380318187 3508 79580
SGTC_1905 st060207 84.5 µM -0.630258151956327 0.29168455965014 no 2419 0.264262848965543 3500 1948547
SGTC_974 1326-0144 138 µM -0.631161736911611 0.291419063628129 no 2420 0.263967388788233 3561 5411856
SGTC_1570 verbenone 133 µM -0.631171751975214 0.291416121581975 no 2421 0.263964114940215 3591 29025 A natural terpanoid with antifungal properties.
SGTC_3207 9114163 49.47 µM -0.631495422026242 0.291321047048205 no 2422 0.263858320808609 3631 849233
SGTC_1308 1187-1617 41.4 µM -0.633459291203694 0.290744492593541 no 2423 0.263216878374591 3573 2882570
SGTC_94 0334-0113 514.748 µM -0.63490391780077 0.290320718750027 no 2424 0.262745540865177 3525 6795178
SGTC_3057 9095946 49.47 µM -0.635639036722591 0.290105186470025 no 2425 0.262505859879456 3573 24540043
SGTC_2859 9028643 45.46 µM -0.637469661685433 0.289568784801257 no 2426 0.261909482674389 3536 17151580
SGTC_3160 9100216 49.47 µM -0.637499772333236 0.289559965805868 no 2427 0.261899679101092 3535 17191039
SGTC_1165 k072-0275 30.3 µM -0.637844370557716 0.289459046698013 no 2428 0.261787496512385 3617 6153523 YGL055W OLE1
SGTC_1454 4239-0054 42.6 µM -0.638469022803742 0.289276153039128 no 2429 0.261584206303018 3679 1340767
SGTC_1004 4084-0029 199 µM -0.638839373404134 0.289167742715673 no 2430 0.261463715672287 3587 716894 YLR208W SEC13
SGTC_1375 2910-0797 186 µM -0.641481709401535 0.288394823767567 no 2431 0.260604880355897 3546 742508
SGTC_718 1130-0073 349 µM -0.641809254805715 0.288299080202523 no 2432 0.260498519917733 3652 6740020
SGTC_785 1270-0111 65.3 µM -0.641957836760535 0.288255653712666 no 2433 0.26045027980384 3576 6741994
SGTC_1234 0326-0494 15.5 µM -0.642731759770879 0.288029506833913 no 2434 0.260199084577495 3631 1547813
SGTC_490 phenamil 164 µM -0.644772235373856 0.287433664331044 no 2435 0.259537398495956 3521 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1218 1348-1416 30.7 µM -0.64980180207202 0.285967467430985 no 2436 0.257910127381423 3594 6787668
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.650517486532719 0.285759123541673 no 2437 0.257679005072694 3626 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_73 0327-0325 16.231 µM -0.651522342081111 0.285466720567301 no 2438 0.257354679762671 3636 53298
SGTC_563 tetrahydrosecaminediol 614 µM -0.651787547329671 0.285389572243284 no 2439 0.257269118004696 3650 334274 A psychoactive constituent of the cannabis plant.
SGTC_77 0828-0286 12.516 µM -0.652297350411216 0.285241298197078 no 2440 0.25710468449049 3579 745345
SGTC_2511 berberine 10.47 µM -0.652335839702676 0.285230105241633 no 2441 0.257092272250827 3605 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1351 1496-0003 46.5 µM -0.653628531862721 0.284854302915517 no 2442 0.256675578797369 3607 3891978
SGTC_1871 st057448 67.3 µM -0.654350682897509 0.284644467166324 no 2443 0.256442949879328 3687 691747
SGTC_1504 k297-0033 30 µM -0.655968376913968 0.284174681096437 no 2444 0.255922235660321 3501 4388117
SGTC_993 3909-8757 62.7 µM -0.656288618347668 0.284081725435394 no 2445 0.255819219656477 3572 4288324 YLR208W SEC13
SGTC_1844 rapamycin 4 nM -0.657113262382581 0.28384242509303 no 2446 0.255554045923177 3597 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1384 3089-0840 101 µM -0.657692214488466 0.283674478840324 no 2447 0.255367963067699 3591 1069836
SGTC_1607 st000305 50.6 µM -0.65866626853597 0.283392026256116 no 2448 0.255055049102946 3607 5457690
SGTC_2742 clothiapine 36.27 µM -0.658802000828542 0.283352677814604 no 2449 0.255011461156908 3561 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2471 5466956 24.79 µM -0.659274892485254 0.283215608209399 no 2450 0.254859631087488 3565 724419
SGTC_471 1-acyl-paf 4 µM -0.659786460434612 0.283067363946131 no 2451 0.254695436616516 3569 16759367
SGTC_3309 9129340 25.759 µM -0.66303594941697 0.282126584292744 no 2452 0.253653765177381 3635 17158987
SGTC_1257 0669-0121 16 µM -0.663676443379739 0.281941328670993 no 2453 0.25344870972724 3649 4307855
SGTC_1940 st075990 51.1 µM -0.664269433773937 0.281769865177633 no 2454 0.253258940331719 3717 1084979
SGTC_581 0958-0271 211 µM -0.665906024953579 0.281296904902447 no 2455 0.252735584620358 3634 4591145
SGTC_792 4534-1957 155 µM -0.666150722091814 0.281226222556958 no 2456 0.252657383353815 3595 1717904
SGTC_2228 7354201 200 µM -0.669435701166268 0.280278166461244 no 2457 0.251608792086876 3645 753451
SGTC_1063 disulfiram 1.84 µM -0.669859720235892 0.280155906017495 no 2458 0.251473609567028 3633 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2557 derrustone 83.84 µM -0.67083770471127 0.279874015354214 no 2459 0.251161962440583 3629 629853 An antioxidant.
SGTC_145 3737-0113 38.366 µM -0.671653290712627 0.2796390390771 no 2460 0.250902221937537 3659 6849351
SGTC_1130 3454-2858 15.9 µM -0.675433533712996 0.278551175694518 no 2461 0.249700183190819 3617 715628 YIL048W NEO1
SGTC_157 1348-1695 65.819 µM -0.678105339924108 0.277783539254573 no 2462 0.248852452607868 3652 5380510
SGTC_473 2-arachidonoylglycerol 10 µM -0.679084261918451 0.277502544044983 no 2463 0.248542236879388 3571 5282280 An endocannabinoid.
SGTC_1264 0783-0040 158 µM -0.679341690575454 0.277428673368713 no 2464 0.248460693189139 3590 2855798
SGTC_1567 st069303 68.4 µM -0.679959210017912 0.277251511707748 no 2465 0.2482651444517 3678 5581319
SGTC_2265 7929201 200 µM -0.68187797010191 0.276701387300278 no 2466 0.247658058253316 3651 1265108
SGTC_648 0375-0473 33.3 µM -0.683774133465128 0.276158267531814 no 2467 0.247058901341873 3656 1713139
SGTC_2650 prasterone 100 µM -0.684261153105534 0.276018854566511 no 2468 0.246905136283117 3608 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1012 4112-3522 18 µM -0.6846784282701 0.275899433969551 no 2469 0.246773432163707 3652 3112398
SGTC_2003 4023581 200 µM -0.687626429221528 0.275056465028969 no 2470 0.245844030252091 3679 16641307
SGTC_2423 st077119 87.2 µM -0.68891597905986 0.274688122731598 no 2471 0.245438071613498 3617 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1159 4092-0538 61.2 µM -0.689620022391743 0.274487125076649 no 2472 0.245216586324311 3697 717301
SGTC_2336 9001819 198.65 µM -0.689836305918015 0.274425392768547 no 2473 0.245148567182407 3716 2989602
SGTC_1103 duloxetine 36.1 µM -0.692223171233277 0.273744581769494 no 2474 0.244398594716715 3716 60835 A selective serotonin reuptake inhibitor.
SGTC_2626 ethyl orsellinate 100 µM -0.692428904492007 0.273685939135571 no 2475 0.244334009582505 3650 75653 A natural product.
SGTC_3206 9114350 49.47 µM -0.694980212053669 0.272959225974063 no 2476 0.24353385127296 3616 17087243
SGTC_2843 9000894 45.46 µM -0.695874347197532 0.272704767572489 no 2477 0.243253761875081 3542 2242070
SGTC_2995 9067767 71.4286 µM -0.696461047485543 0.272537864829752 no 2478 0.243070071639835 3657 11673567
SGTC_1868 st057644 42.7 µM -0.69652414640056 0.272519917660133 no 2479 0.243050320443318 3682 688665
SGTC_2824 7998404 51.95 µM -0.697802884661917 0.272156333742103 no 2480 0.242650237419335 3650 837851
SGTC_1307 1187-1599 12.2 µM -0.699695614172814 0.271618616519672 no 2481 0.242058708019818 3671 1538471
SGTC_2782 7736369 71.43 µM -0.700877118135226 0.271283224135165 no 2482 0.24168985273311 3732 2950836 YOL077C BRX1
SGTC_1689 st020265 53.493 µM -0.701558771469763 0.271089817807776 no 2483 0.241477185347479 3683 5758320 YPR016C TIF6
SGTC_2832 7992762 51.95 µM -0.703552394113211 0.270524559803615 no 2484 0.240855783545967 3620 2985177
SGTC_1330 1469-0054 61.8 µM -0.703582790815172 0.270515945892227 no 2485 0.240846315790135 3692 7102664
SGTC_2894 9048625 32.47 µM -0.703660280741048 0.270493987177407 no 2486 0.240822180676604 3718 4092861
SGTC_2961 9083290 32.55 µM -0.704324286256219 0.270305861074621 no 2487 0.240615422610833 3653 17741490
SGTC_1150 3909-7983 10.9 µM -0.705416408427743 0.269996583259224 no 2488 0.240275567844931 3687 23965914
SGTC_2793 7325131 81.82 µM -0.706796055119881 0.269606134760518 no 2489 0.239846613218715 3673 4176441
SGTC_771 0250-0039 27.3 µM -0.707784146692198 0.269326672730996 no 2490 0.239539656369616 3681 3005115
SGTC_1359 1582-0056 520 nM -0.707888377092903 0.269297201709138 no 2491 0.239507289051295 3735 3661189
SGTC_429 1112-0049 25.5 µM -0.709427247473958 0.268862276230275 no 2492 0.239029692004956 3670 2836170
SGTC_2444 5485484 36.41 µM -0.709861551128782 0.268739594381638 no 2493 0.238894997696222 3755 6790631
SGTC_1289 0976-0073 69.1 µM -0.711619393255577 0.268243327574808 no 2494 0.238350247319619 3733 3391136
SGTC_1126 isoteolin 1.0172 µM -0.711849365777036 0.268178436794794 no 2495 0.238279029833339 3679 133323
SGTC_2580 diallyl disulphide 81.36 µM -0.712026263752903 0.268128527304334 no 2496 0.238224256311505 3716 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1158 4092-0494 91.8 µM -0.71323836480387 0.26778667437582 no 2497 0.237849134963791 3810 1148199
SGTC_2770 toltrazuril 17.5 µM -0.713283442242365 0.267773965270867 no 2498 0.23783519063657 3670 68591 Kills coccidiodes.
SGTC_2831 7999036 19.48 µM -0.713530599086504 0.267704287425699 no 2499 0.237758742710155 3698 2988270
SGTC_135 0933-0004 26.348 µM -0.715501974970593 0.267148849312612 no 2500 0.237149460462255 3683 21230617 YGL099W LSG1
SGTC_578 3460-0051 92 µM -0.71653074439977 0.266859223167128 no 2501 0.236831845331343 3764 2876744
SGTC_561 1550-0330 72.9 µM -0.717579361878269 0.266564172617705 no 2502 0.236508343311276 3666 6812934
SGTC_1987 st072290 61.9 µM -0.721837656582723 0.265367709599499 no 2503 0.235197147295941 3710 54697379
SGTC_1829 berberine 14.4 µM -0.722533702410885 0.26517239946153 no 2504 0.234983206166195 3714 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2569 tetrandrine 100 µM -0.723591442388779 0.264875737931584 no 2505 0.234658298344231 3726 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1246 0422-0085 105 µM -0.725374904768894 0.26437591725859 no 2506 0.234111032121143 3704 264295
SGTC_1430 4049-0248 69.1 µM -0.726072056308183 0.264180669051661 no 2507 0.233897299248692 3735 22774488
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.727216135153903 0.263860411092264 no 2508 0.233546781721747 3722 91467 include heat shock
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.727383287860986 0.26381363720143 no 2509 0.23349559465798 3751 368090
SGTC_281 1672-3440 14.9 µM -0.727700217628415 0.263724963209175 no 2510 0.233398558549722 3745 6833000
SGTC_3305 9127027 53.8275 µM -0.728226970143905 0.263577616406705 no 2511 0.233237329375937 3663 41905295
SGTC_105 0111-0055 734.78 µM -0.72844383324522 0.263516966191873 no 2512 0.233170969571247 3729 5179370
SGTC_840 0245-0196 390 µM -0.728660082193518 0.263456494830478 no 2513 0.233104808134232 3798 3827528
SGTC_2048 5246248 200 µM -0.729064382025023 0.263343456354365 no 2514 0.232981140432118 3703 677046
SGTC_520 3584-0023 682 µM -0.729525599255678 0.263214534549101 no 2515 0.232840107275065 3741 1340790
SGTC_2515 chrysin 20.77 µM -0.732812294048608 0.26229675516682 no 2516 0.231836460962739 3743 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2524 avocatin b 10.57 µM -0.732827075814907 0.262292631199715 no 2517 0.231831952557272 3692 6710748
SGTC_1011 4112-3381 17.4 µM -0.735404019248519 0.261574197303776 no 2518 0.231046737388488 3784 2877139
SGTC_464 bw-b 70c 158 µM -0.73649551261999 0.261270201359156 no 2519 0.230714598733193 3771 5353454
SGTC_776 4476-4378 112 µM -0.740560396080912 0.260139674154993 no 2520 0.229480014255887 3790 2892008
SGTC_397 arbidol 50 µM -0.742770947601719 0.259525934804265 no 2521 0.228810183745308 3808 131410 A RNA synthesis inhibitor.
SGTC_1119 parthenolide 318.541 nM -0.744892248574902 0.258937678895209 no 2522 0.228168430737949 3880 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1970 st070122 35.8 µM -0.747231066527387 0.258289903934647 no 2523 0.227462047232037 3747 102928
SGTC_1805 st050013 60.3 µM -0.749503477251958 0.257661326950405 no 2524 0.226776901799857 3725 4037144
SGTC_1 0258-0098 57.368 µM -0.750783939147885 0.25730748549351 no 2525 0.226391348365678 3686 6790032 YDR047W HEM12
SGTC_2391 6285546 200 µM -0.751269535804384 0.25717336231821 no 2526 0.226245229675666 3745 846083
SGTC_2485 5633444 17.78 µM -0.752743678686433 0.25676642265166 no 2527 0.225801978560099 3775 5724239
SGTC_1336 1486-0901 104 µM -0.753076241370809 0.256674664514477 no 2528 0.225702050240234 3789 5006114
SGTC_1120 ficusin 1.78878 µM -0.753593032993883 0.25653210923437 no 2529 0.225546814530883 3866 6199 A DNA cross-linker.
SGTC_2540 epiandrosterone 100 µM -0.75595426049879 0.255881297425649 no 2530 0.224838309875468 3820 441302 A steroid.
SGTC_808 0711-0032 135 µM -0.758209874494722 0.25526040094422 no 2531 0.224162675378586 3724 4252555
SGTC_1315 1237-0019 3.69 µM -0.759696815572433 0.254851526068289 no 2532 0.223717916335858 3755 825140
SGTC_348 k064-0012 10.7 µM -0.760523073302476 0.254624472299635 no 2533 0.223470991338112 3696 5066323
SGTC_2779 methotrexate 400 µM -0.760802119983741 0.254547814838324 no 2534 0.223387633990698 3808 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1489 4065-0444 182 µM -0.76144508971503 0.254371229396091 no 2535 0.22319563223091 3726 2877968
SGTC_2588 indole-3-carbinol 100 µM -0.762437610021281 0.254098769363583 no 2536 0.222899433205561 3792 3712 Induces cell cycle arrest.
SGTC_2360 9040895 200 µM -0.766932992329685 0.252866646522427 no 2537 0.221560678271353 3812 4914414
SGTC_1931 st074438 57.1 µM -0.768693150479555 0.252385069402164 no 2538 0.221037746029296 3752 2787313
SGTC_400 oxethazaine 37.5 µM -0.769701733497197 0.252109340343821 no 2539 0.220738420781021 3795 4621 A local anesthetic.
SGTC_2760 etidronate 98.04 µM -0.770240981432681 0.251961984552721 no 2540 0.220578479145135 3792 3305 A chelator and antioxidant.
SGTC_3257 9139206 32.98 µM -0.771060802488756 0.251738045989527 no 2541 0.220335446409473 3797 4910041
SGTC_2463 5473429 200 µM -0.771880792068071 0.251514166569866 no 2542 0.220092517343305 3790 5399405
SGTC_2902 5787006 60.46 µM -0.77401951515342 0.250930732501229 no 2543 0.219459625425927 3754 591003
SGTC_92 0063-0024 660.874 µM -0.775933493081892 0.250409215869816 no 2544 0.218894127767302 3870 3594437
SGTC_911 3456-4043 236 µM -0.776252498163272 0.250322349932929 no 2545 0.218799957139336 3875 914281
SGTC_2397 5161689 200 µM -0.778144164483283 0.249807572550083 no 2546 0.218242014502861 3808 2259942
SGTC_1709 st033179 39.1045 µM -0.778283293241978 0.249769733772427 no 2547 0.218201011184934 3774 573381
SGTC_1428 4049-0204 61.7 µM -0.779474848011471 0.249445791909905 no 2548 0.217850024108848 3851 X1428
SGTC_3066 9117245 49.47 µM -0.780517863327862 0.249162416076373 no 2549 0.217543058587967 3875 17176980
SGTC_3283 9109332 35.8195 µM -0.780577813957193 0.249146133352389 no 2550 0.217525422356686 3664 17027281
SGTC_1102 cgs 12066b 26.1 µM -0.782176098242133 0.248712244552188 no 2551 0.217055544649886 3816 6438352 A 5-HT1B full agonist.
SGTC_2197 6588183 93.1375 µM -0.783016930195996 0.248484144186348 no 2552 0.216808585083026 3745 884136
SGTC_636 0kpi-0074 126 µM -0.783120551941509 0.248456041461574 no 2553 0.216778161734825 3834 616434
SGTC_1255 0566-0045 221 µM -0.783441108765836 0.248369115606759 no 2554 0.216684061871403 3869 2788469
SGTC_1391 3442-0225 151 µM -0.783888111636678 0.248247928264912 no 2555 0.216552883059346 3757 5227075
SGTC_1701 st028638 40.4 µM -0.785522482856026 0.247805100972006 no 2556 0.2160736468259 3769 3490878
SGTC_263 alizarin 107.927 µM -0.785911012176356 0.247699892357791 no 2557 0.215959811294658 3815 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_645 0845-0943 5.41 µM -0.786438289515455 0.247557150771598 no 2558 0.215805379453442 3824 1885106
SGTC_1055 3448-0672 86 µM -0.786810439793259 0.247456430779775 no 2559 0.21569642060602 3836 748378
SGTC_253 dyclonine 31.25 µM -0.787820427316928 0.247183194785863 no 2560 0.215400875368957 3883 3180 An oral anasthetic.
SGTC_3100 9120536 49.47 µM -0.788440741723709 0.247015458643428 no 2561 0.215219473832288 3656 16421196
SGTC_743 1275-0778 158 µM -0.789817752208124 0.246643325817262 no 2562 0.214817105038547 3825 2849257 YMR203W TOM40
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.792246078732501 0.245987810396121 no 2563 0.214108602774138 3848 6710655
SGTC_1292 0kpi-0043 232 µM -0.793290041072399 0.245706285212929 no 2564 0.213804428883539 3846 3333905
SGTC_2124 5246320 200 µM -0.794407226977195 0.24540520557871 no 2565 0.213479199139236 3836 579342
SGTC_1271 0832-2808 169 µM -0.794696604066146 0.245327251303757 no 2566 0.213395004122492 3870 3663794
SGTC_3319 9138450 16.7555 µM -0.795042898147609 0.245233981858009 no 2567 0.213294274405052 3771 2029690
SGTC_2806 7952793 58.44 µM -0.795968625319762 0.244984743880871 no 2568 0.213025135854199 3858 2972490
SGTC_65 0798-0905 34.986 µM -0.796226195081408 0.244915421378026 no 2569 0.212950287320191 3874 3602145
SGTC_2482 5981709 142.65 µM -0.796410305830017 0.244865876154462 no 2570 0.212896795028689 3836 877755
SGTC_3230 9131665 49.47 µM -0.796510887444704 0.244838811362666 no 2571 0.212867574946765 3745 15943720
SGTC_258 haloperidol 50.781 µM -0.796863109741417 0.244744047060992 no 2572 0.212765268889801 3852 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_456 gingerol 170 µM -0.796912339486933 0.244730803525741 no 2573 0.212750971964955 3844 442793 A herb.
SGTC_982 1491-0518 27.5 µM -0.797511890077994 0.244569546447575 no 2574 0.212576900097895 3775 3091256
SGTC_2972 9093619 59.92 µM -0.798237941071212 0.244374342053089 no 2575 0.212366211854942 3835 25236256
SGTC_2102 5377816 72.7585 µM -0.798809367174358 0.244220768814987 no 2576 0.212200479093497 3848 1379702
SGTC_552 k242-0005 476 µM -0.798923570095348 0.244190082525547 no 2577 0.212167365478601 3889 4088318
SGTC_1969 st069479 40.1 µM -0.799900835454202 0.243927576658786 no 2578 0.211884126854116 3827 3895485
SGTC_2927 9011802 47.9 µM -0.801376502230635 0.243531482567524 no 2579 0.211456857118276 3839 43912568
SGTC_1117 retinoic acid 1.10837 µM -0.801451722195444 0.243511301557957 no 2580 0.211435091189168 3824 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2199 6590217 200 µM -0.805912229121161 0.242316194258862 no 2581 0.210146729717134 3765 703109
SGTC_2914 7968218 45.32 µM -0.806742003792131 0.242094223213282 no 2582 0.209907569442924 3836 2977111
SGTC_1327 1436-0082 2.18 µM -0.8069659226631 0.242034342105971 no 2583 0.209843058258535 3838 15992205
SGTC_1209 2323-2347 50.3 µM -0.807927966240379 0.241777160723148 no 2584 0.209566025456635 3791 5412760
SGTC_56 0957-0365 83.25 µM -0.809843195792044 0.241265607657987 no 2585 0.209015151385431 3849 6752360
SGTC_932 2857-0803 154 µM -0.811502457350704 0.240822898972037 no 2586 0.208538591139299 3952 674898
SGTC_799 1310-0557 151 µM -0.812413682138955 0.240579962618779 no 2587 0.208277148967887 3939 5354492
SGTC_1423 4048-0112 5.59 µM -0.812976294166955 0.240430034537755 no 2588 0.208115824903287 3878 X1423
SGTC_480 am 92016 50 µM -0.813054075791711 0.240409310848977 no 2589 0.208093527508658 3797 2129 K+ channel blocker.
SGTC_758 0868-0029 16 µM -0.813387657941443 0.240320444174509 no 2590 0.207997916636689 3925 762687
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.814329711980398 0.240069576542659 no 2591 0.207728046433659 3849 77254
SGTC_1017 4239-0030 168 µM -0.816612712539552 0.239462209469523 no 2592 0.207074893935651 3900 1149593
SGTC_1520 flindersine 88 µM -0.816811058790554 0.239409481286286 no 2593 0.207018205708224 3989 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_626 0214-0009 33 µM -0.817858757344371 0.239131067309811 no 2594 0.206718921258012 3914 3437874
SGTC_2723 salbutamol 83.58 µM -0.818960793245113 0.238838404862661 no 2595 0.206404391485786 3835 9884233 β2-adrenoceptor agonist
SGTC_1834 st055981 52.8 µM -0.82040516348512 0.238455127140335 no 2596 0.205992586446701 3920 471719 YDL150W RPC53
SGTC_3114 9122766 49.47 µM -0.820593259405133 0.238405238849455 no 2597 0.205938994219971 3870 17176985
SGTC_1031 k035-0009 16 µM -0.821618447439284 0.238133430845523 no 2598 0.205647043399813 3942 5180959
SGTC_2628 lathosterol 100 µM -0.822414947484919 0.23792237213967 no 2599 0.205420387519976 3942 6710616
SGTC_3145 9085516 49.47 µM -0.822439694224969 0.237915816325711 no 2600 0.205413347845831 3927 25236195
SGTC_1964 st076914 61 µM -0.824198736751026 0.237450071176987 no 2601 0.204913322354052 3907 24208661
SGTC_1393 3470-5649 58.2 µM -0.824232031976404 0.237441260363905 no 2602 0.204903864836139 3843 4108395
SGTC_2733 amorolfine 100 µM -0.824748262577923 0.237304674814591 no 2603 0.204757262601919 3896 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3128 9127691 49.47 µM -0.824884794955955 0.237268557962019 no 2604 0.204718499760139 3906 41316314
SGTC_252 miconazole 1.30953 nM -0.82575665110621 0.237037997429437 no 2605 0.204471074451358 3803 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1406 3909-7906 11.9 µM -0.826641644046243 0.236804088877703 no 2606 0.204220103146751 3876 X1406
SGTC_690 glyoxal 20.3 µM -0.826980299589299 0.236714613925839 no 2607 0.20412411384287 3717 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1389 3405-0187 19 µM -0.827619706378189 0.236545729289126 no 2608 0.203942952203469 3836 799890
SGTC_1841 st054148 70 µM -0.828933490353343 0.236198931554689 no 2609 0.203571021645182 3924 675442
SGTC_51 1013-0126 23.419 µM -0.828995158401108 0.23618266000926 no 2610 0.203553573445495 3891 1627850
SGTC_26 0302-0163 425.158 µM -0.831203315189333 0.235600429443442 no 2611 0.202929391162312 3925 3100915
SGTC_872 0588-0139 234 µM -0.832131281750783 0.235355986519423 no 2612 0.202667423280622 3857 2047100
SGTC_3055 9094636 49.47 µM -0.832281821794915 0.235316344791428 no 2613 0.202624944413127 3873 25236176
SGTC_2372 9071633 200 µM -0.832351354239286 0.235298036048962 no 2614 0.202605325785883 3939 21321366
SGTC_132 0417-1715 25.805 µM -0.833156724743508 0.235086029468498 no 2615 0.202378172686085 3837 6769098
SGTC_2757 clomiphene 4.22 µM -0.834197699306326 0.234812158627758 no 2616 0.202084793700584 3927 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1151 3909-8316 15.3 µM -0.834199535796148 0.234811675620058 no 2617 0.202084276345672 3927 800431
SGTC_378 3970-0959 8.33 µM -0.835646141593483 0.234431380371863 no 2618 0.201677001347256 3918 6615653
SGTC_3333 9141820 12.094 µM -0.835662729029837 0.234427021711699 no 2619 0.201672334200734 3873 1939433
SGTC_123 0083-0120 66.675 µM -0.837192938346963 0.234025123423768 no 2620 0.201242063094078 3873 16001701
SGTC_1455 4262-0120 131 µM -0.838237366720565 0.233751031232983 no 2621 0.200948702332834 3992 1529587
SGTC_1407 3909-7909 12.3 µM -0.84114117467553 0.232989912871982 no 2622 0.200134425359618 3870 4411780
SGTC_3214 9129694 49.47 µM -0.841741614773501 0.232832703160892 no 2623 0.1999662995552 3878 17158655
SGTC_1630 st005209 31.3 µM -0.843331421966719 0.232416738012142 no 2624 0.199521557007797 3832 3367314
SGTC_3263 9137018 49.47 µM -0.846287082709459 0.231644503748803 no 2625 0.198696306048954 3920 43844957
SGTC_2575 plumbagin 510 nM -0.846759307405967 0.231521256817036 no 2626 0.198564646998683 3825 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1447 4239-0816 81.9 µM -0.847504471280801 0.231326849282502 no 2627 0.198356997947304 3897 1341554
SGTC_491 tetrandrine 80.3 µM -0.84753843505425 0.231317990564813 no 2628 0.198347536648861 3906 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2076 5212012 200 µM -0.849367600816973 0.230841171738973 no 2629 0.19783838778333 3802 604802
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.850818860990802 0.230463254494275 no 2630 0.197434991369661 3891 16486 A toxic proline analog.
SGTC_726 3448-4391 34.2 µM -0.851409359187457 0.230309584107444 no 2631 0.197270997273149 4008 1356692
SGTC_742 0kpi-0133 140 µM -0.852319437073633 0.230072859015471 no 2632 0.197018410419106 3966 2728852
SGTC_2054 5233173 129 µM -0.853210819001045 0.229841129066214 no 2633 0.196771202376001 3942 6889
SGTC_935 2996-0153 430 µM -0.854676189905289 0.229460465019504 no 2634 0.196365217724567 3913 23738523
SGTC_1077 5-fluorocytosine 377 nM -0.854775385750122 0.229434709374664 no 2635 0.196337753629789 3925 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2108 5365811 200 µM -0.855937727986319 0.229133034482361 no 2636 0.196016112490612 3953 780283
SGTC_894 0960-0238 55.9 µM -0.857039886138559 0.228847185410936 no 2637 0.195711420802028 3849 6741907 YDL195W SEC31
SGTC_166 k072-0058 166.424 µM -0.857270239004627 0.228787467783015 no 2638 0.195647776080043 3860 5846229
SGTC_1449 4112-4002 201 µM -0.85784954651376 0.228637324383183 no 2639 0.195487773423466 3969 2059539
SGTC_2969 9091408 28.7 µM -0.85786287146687 0.228633871507953 no 2640 0.195484094054428 3867 4286311
SGTC_3239 9133757 49.47 µM -0.858022392662121 0.228592537292334 no 2641 0.195440049334246 3916 17036923
SGTC_2982 9019404 25.97 µM -0.858189855522306 0.228549149794118 no 2642 0.195393818360409 3867 22333232
SGTC_3332 9141069 11.198 µM -0.866068699373726 0.226513077207565 no 2643 0.193226244444571 3854 17332883
SGTC_2175 5807670 165.306 µM -0.870850913158763 0.225282255621125 no 2644 0.191917780890642 3924 241186
SGTC_2881 9058953 51.95 µM -0.871920450631516 0.225007502752226 no 2645 0.191625888118084 3899 17122249
SGTC_545 4218-0007 221 µM -0.875959165709664 0.223971713720855 no 2646 0.190526116538283 3941 2840508
SGTC_541 4513-1321 94 µM -0.876391833373879 0.223860910499284 no 2647 0.190408528228236 3936 747515
SGTC_2835 9006588 71.43 µM -0.880341849342078 0.222850780110493 no 2648 0.189337074034075 4027 2345538
SGTC_1181 1222-0449 220 µM -0.880781832279889 0.222738425043475 no 2649 0.189217957435221 3971 658318
SGTC_1935 st074532 41.6 µM -0.88106623812192 0.222665815687542 no 2650 0.18914098478803 3949 2829742
SGTC_1954 st077032 68.9 µM -0.881559012452314 0.222540041403243 no 2651 0.189007664179968 3920 698907
SGTC_2340 7987427 183.45 µM -0.882188667098124 0.222379389151556 no 2652 0.188837394724171 3971 2239331
SGTC_621 3584-0052 32.1 µM -0.885859629674346 0.221444085301983 no 2653 0.18784658631419 3933 2273927
SGTC_2317 5986382 200 µM -0.885949888208767 0.221421117203296 no 2654 0.187822265658864 3967 877883
SGTC_1027 k015-0025 8.67 µM -0.886746251615138 0.221218525558703 no 2655 0.187607765466978 3935 3598955
SGTC_3014 9081533 49.47 µM -0.889186878848896 0.220598300692117 no 2656 0.186951326677275 4000 21367265
SGTC_2950 9072895 21.46 µM -0.889498427038361 0.220519200213304 no 2657 0.186867634097882 3916 17332245
SGTC_2283 7944793 200 µM -0.890850920007567 0.220175997708442 no 2658 0.186504576755922 3992 2970533
SGTC_1925 st057770 10.1 µM -0.891216810339352 0.220083203703463 no 2659 0.18640643386967 3942 5989122
SGTC_2929 9013348 24.6 µM -0.89236594048654 0.219791916964934 no 2660 0.186098410372893 3987 2995952
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.892910925077448 0.219653849194202 no 2661 0.185952438011372 4025 1273210
SGTC_192 3455-0609 60.9 µM -0.893669574286461 0.219461734034568 no 2662 0.185749354511841 4030 3769639
SGTC_3098 9119039 49.47 µM -0.893675569992133 0.219460216107461 no 2663 0.185747750064076 3948 17161528
SGTC_597 k018-0003 82.8 µM -0.893908707525167 0.219401197577024 no 2664 0.185685369246178 4033 6786234
SGTC_1751 st044839 27.194 µM -0.894436490552342 0.219267623534381 no 2665 0.185544197894609 3919 5291326
SGTC_3354 9151612 71.43 µM -0.895123748391948 0.219093758865591 no 2666 0.185360470103521 3991 27261949
SGTC_1408 3909-7976 48.8 µM -0.897662235172862 0.218452252007632 no 2667 0.184682824364127 4016 24152374
SGTC_2568 diosmetin 100 µM -0.897762277992199 0.218426992131436 no 2668 0.184656149649296 4015 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2217 6934799 96.0675 µM -0.900515909501637 0.217732386593969 no 2669 0.183922881309122 3902 675606
SGTC_838 0109-0203 71.4 µM -0.900604829285128 0.217709977774273 no 2670 0.183899232999645 3981 759422
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.901835229838747 0.217400039140884 no 2671 0.183572201095344 3959 15053
SGTC_170 4197-0004 226 µM -0.902335933502074 0.217273984556328 no 2672 0.183439221366454 4016 218692
SGTC_1656 st012921 11 µM -0.904787540009064 0.216657390351721 no 2673 0.182788976948035 3910 6732821
SGTC_474 dl-dihydrosphingosine 5 µM -0.907696416131601 0.215927104533241 no 2674 0.182019318982348 3976 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2308 7584454 197.62 µM -0.908071017723756 0.215833162972679 no 2675 0.18192035083204 4021 893577
SGTC_3015 9080845 49.47 µM -0.908136214791511 0.215816815451039 no 2676 0.181903129482392 4040 5296973
SGTC_1895 st058434 18.3 µM -0.908313384300523 0.215772395569084 no 2677 0.181856336545256 3993 5393175
SGTC_2810 7959871 45.46 µM -0.90882966119325 0.2156429850188 no 2678 0.181720023561307 3961 2974535
SGTC_2502 avocadyne acetate 18.59 µM -0.910608037582673 0.215197559817126 no 2679 0.181250967010838 3911 3952079
SGTC_2438 5259590 200 µM -0.911229854594788 0.215041941061665 no 2680 0.181087138427509 4003 1201127
SGTC_2910 7948405 25.97 µM -0.911731957499772 0.214916330201026 no 2681 0.18095491834411 3883 2971328
SGTC_1619 st003326 88.7 µM -0.913903545629549 0.214373555929334 no 2682 0.180383765217649 3971 2849032
SGTC_2009 4012297 12.05 µM -0.914355637887942 0.214260658764107 no 2683 0.180265002054942 4005 45595307
SGTC_2182 6325192 200 µM -0.915908239761609 0.213873204117334 no 2684 0.179857512358113 3905 736248
SGTC_1564 D-Arginine 115 µM -0.916250980655905 0.213787727500553 no 2685 0.179767635967257 4011 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1784 st039334 36.3 µM -0.91922397646671 0.213047123227298 no 2686 0.17898921631088 4075 3496984
SGTC_505 gw-5074 63.9 µM -0.919283556837387 0.213032296450417 no 2687 0.178973638089215 4046 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2153 5569715 200 µM -0.919284929092569 0.213031954967163 no 2688 0.178973279301643 4007 2054701
SGTC_868 0527-0199 213 µM -0.919567003322717 0.212961768078309 no 2689 0.178899538248364 3947 2849450
SGTC_2586 curcumin 80 µM -0.920686884771909 0.212683247658493 no 2690 0.178606962742826 3962 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2983 9022671 12.99 µM -0.921738581195399 0.212421878981908 no 2691 0.178332475498547 4014 6405161
SGTC_136 0097-0015 404.482 µM -0.922690996544625 0.212185345749693 no 2692 0.178084129573433 3995 4861337
SGTC_1655 st012546 55.1 µM -0.923170698406311 0.21206626967773 no 2693 0.177959128093061 3991 720985 YLR208W SEC13
SGTC_3297 9117502 71.43 µM -0.923273226838212 0.212040824183137 no 2694 0.177932418248299 4016 7453720
SGTC_1283 0922-0125 16.4 µM -0.924232472244582 0.211802845277139 no 2695 0.177682646189289 3999 3360884
SGTC_1772 st048439 82.2 µM -0.924589697727865 0.211714261265765 no 2696 0.177589686985568 4049 2927068 YDL195W SEC31
SGTC_2970 9090938 41.86 µM -0.924687308346112 0.211690059765781 no 2697 0.177564291547175 4079 17217104
SGTC_2464 5717415 7.67 µM -0.928576916665239 0.210726991833893 no 2698 0.176554194608517 4001 5285744
SGTC_2206 7254556 146.969 µM -0.929208458191638 0.210570864893293 no 2699 0.176390532440823 4010 4398905
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.931702936331159 0.209954854805723 no 2700 0.175745034284878 4091 4213774
SGTC_3150 9097574 49.47 µM -0.932611626632882 0.209730717630745 no 2701 0.175510264076861 4042 17217476
SGTC_3130 9127414 49.47 µM -0.933259513751534 0.209570996011353 no 2702 0.175342996705704 4012 1494646
SGTC_1865 st057639 52.2 µM -0.933929089048591 0.209406002874555 no 2703 0.175170236259481 3992 688818
SGTC_2137 5261020 140 µM -0.934012989422768 0.209385333986605 no 2704 0.17514859632148 3976 763655
SGTC_1066 ketoconazole 628 nM -0.934995851542948 0.209143294960198 no 2705 0.174895218674466 4074 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_162 k030-0015 37.8 µM -0.936243603754862 0.20883626169196 no 2706 0.174573888780519 4085 1809920 YMR134W ERG29
SGTC_1695 st026914 34.495 µM -0.936949327663331 0.208662722489627 no 2707 0.174392311910381 3980 3289191
SGTC_2706 st078239 82.5 µM -0.937774663583501 0.208459878278234 no 2708 0.17418011213082 3985 15434492
SGTC_1608 st001473 40.5 µM -0.938390516244492 0.20830859491023 no 2709 0.174021878955169 3999 7292267
SGTC_2168 5727979 200 µM -0.939062976984312 0.208143479838386 no 2710 0.173849205677161 3904 695210
SGTC_699 0375-0592 111 µM -0.94078320026985 0.207721450280221 no 2711 0.173407985894486 4097 762578
SGTC_35 0133-0054 64.071 µM -0.941949906686714 0.207435505226379 no 2712 0.173109143598473 4037 99677
SGTC_89 0302-0250 142.109 µM -0.943252066837923 0.207116637097088 no 2713 0.1727759935555 4112 4203518 YLR208W SEC13
SGTC_1196 1588-0294 184 µM -0.944097866063043 0.206909676357189 no 2714 0.172559819855482 4029 6144269
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.945799660681956 0.206493631024208 no 2715 0.172125389344774 4016 2724 A muscle relaxant with antifungal properties.
SGTC_465 cgp-37157 41 µM -0.945823980546601 0.206487689032285 no 2716 0.172119186084787 3970 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3209 9113616 49.47 µM -0.946306464358465 0.206369826302029 no 2717 0.171996148591439 4085 16649353
SGTC_2488 5268135 45.7 µM -0.946928814630116 0.206217855424711 no 2718 0.171837526901382 4082 1270356 YLR208W SEC13
SGTC_2773 thioridazine 9.09 µM -0.949685297698791 0.20554555157717 no 2719 0.171136091229724 4053 5452 An antipsychotic.
SGTC_2376 9072922 81.32 µM -0.951138255762937 0.205191700710168 no 2720 0.170767098483026 4071 17087968
SGTC_3087 9117406 49.47 µM -0.951173890688283 0.205183026792692 no 2721 0.170758055051147 4066 42546093
SGTC_279 1273-0055 2.93 µM -0.952626748854253 0.204829571311756 no 2722 0.170389609702383 4055 2847562
SGTC_1986 st071812 45 µM -0.952982270278634 0.204743134219951 no 2723 0.170299526946063 3965 11838594
SGTC_37 0566-0070 1.56 µM -0.953286500574867 0.204669184649528 no 2724 0.170222464671457 4011 1626686
SGTC_3162 9099653 49.47 µM -0.953503861137416 0.204616360327325 no 2725 0.170167420397943 4018 25237511
SGTC_381 3461-2219 42.7 µM -0.954577639990269 0.204355522920938 no 2726 0.169895664581437 4046 2883159
SGTC_2839 9003951 25.97 µM -0.955038002380705 0.204243754465829 no 2727 0.169779239677596 4091 2990634
SGTC_1636 st007707 68.9 µM -0.955891995596592 0.204036515308546 no 2728 0.169563401697984 4080 403051
SGTC_1498 4478-3555 97.6 µM -0.956517896604354 0.203884707039164 no 2729 0.169405323514952 3970 3437919
SGTC_2320 7373003 200 µM -0.957090411113948 0.203745906286008 no 2730 0.169260811529185 4128 5415828
SGTC_3313 9133968 57.047 µM -0.957530269856275 0.203639304950562 no 2731 0.16914983779356 4030 1494643
SGTC_2358 9037157 4 µM -0.957949449672103 0.20353774618311 no 2732 0.169044124713813 4031 2388925
SGTC_1432 4049-0298 68.4 µM -0.968662464952793 0.20095246497836 no 2733 0.16635681302363 4069 741646
SGTC_1394 3474-0001 65.7 µM -0.968674332507932 0.200949612049919 no 2734 0.166353851480527 4035 5017666 YIL048W NEO1
SGTC_513 4245-1575 41.7 µM -0.969608415592734 0.200725137214747 no 2735 0.16612085826079 3957 719745
SGTC_416 estradiol valerate 100 µM -0.970128757535265 0.200600156178149 no 2736 0.165991158129215 4084 13791 A steroid.
SGTC_1362 1611-0397 101 µM -0.970405745813727 0.200533645368022 no 2737 0.165922142886712 4021 27816
SGTC_1016 4226-1401 38 µM -0.971241075835257 0.200333144966903 no 2738 0.165714121831875 4017 2901613
SGTC_1457 k015-0032 57.3 µM -0.971673277777206 0.200229452829577 no 2739 0.165606557416554 4054 4302660
SGTC_1348 1493-0373 93.8 µM -0.973381308379461 0.199819984743062 no 2740 0.165181912604348 4049 3010129
SGTC_1303 1160-0052 261 µM -0.974228058466581 0.199617179268159 no 2741 0.164971657982948 4012 3562476
SGTC_1068 loratadine 26.9 µM -0.974417147590597 0.199571907375526 no 2742 0.164924729365998 4092 3957 A H1 histamine antagonist.
SGTC_193 1273-0060 1.558 µM -0.974800118851363 0.199480234975643 no 2743 0.164829709078471 3870 2847393 YHR072W ERG7
SGTC_2382 9035899 200 µM -0.975947562261531 0.199205721524037 no 2744 0.164545225359627 4049 6462679
SGTC_801 0866-0028 10.1 µM -0.978462398054651 0.198604870571107 no 2745 0.163922839995299 4058 6849771
SGTC_2385 9074692 200 µM -0.979576164781968 0.198339116208483 no 2746 0.163647687606426 4081 17046906
SGTC_2119 5528445 120.635 µM -0.98030276936295 0.198165857806016 no 2747 0.163468344061685 4091 791935
SGTC_2551 apiole 73.87 µM -0.982298485485257 0.197690450917537 no 2748 0.162976410227827 3934 10659 A possible DNA adduct former.
SGTC_194 1486-1323 56.904 µM -0.982527178905235 0.197636017068961 no 2749 0.162920099993002 4122 5178754
SGTC_2419 paclitaxel 166.5 µM -0.982822756679489 0.197565676758692 no 2750 0.162847339842787 3996 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1033 k072-0102 21.3 µM -0.983380802624266 0.197432916683385 no 2751 0.162710027499469 4053 5965931
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.983829824677596 0.197326132753876 no 2752 0.162599596182359 4018 16623 A steroid.
SGTC_1163 k060-0048 49.9 µM -0.98468694735464 0.197122393612228 no 2753 0.16238893306949 4062 6809982
SGTC_3205 9113483 49.47 µM -0.984687352675254 0.197122297297128 no 2754 0.162388833492066 4132 17018033
SGTC_455 paf C-16 10 µM -0.984727324242522 0.197112799115584 no 2755 0.162379013644704 4038 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1698 5-fluorocytosine 1.055 µM -0.985310626307511 0.196974224380526 no 2756 0.162235757328115 4104 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_68 0986-0284 82.829 µM -0.986439492064724 0.196706207947999 no 2757 0.161958746858457 4148 423278 YIL048W NEO1
SGTC_1693 xanthone 101.9 µM -0.987315016209715 0.196498492299978 no 2758 0.161744115737428 4118 7020 An insecticide.
SGTC_2612 dictamnine 15.46 µM -0.987587378784236 0.196433902157724 no 2759 0.161677384998103 4039 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1667 st014849 34.6 µM -0.992636283547392 0.19523889767491 no 2760 0.16044361802627 4126 5348460
SGTC_2247 cerulenin 830 nM -0.994453598997563 0.19480984824621 no 2761 0.160001042401346 4135 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2333 9017922 200 µM -0.994718491002971 0.194747357898925 no 2762 0.159936599280818 4137 3163164
SGTC_3153 9100258 49.47 µM -0.996008519406002 0.194443203217223 no 2763 0.159623002906359 4026 25236848
SGTC_478 N-arachidonylglycine 10 µM -0.999888027277191 0.193530261372381 no 2764 0.158682349569223 4031 5283389
SGTC_3121 9125696 49.47 µM -1.00013666277927 0.193471840724333 no 2765 0.158622187799352 4168 1235365
SGTC_2386 9075165 157.42 µM -1.00225911494961 0.192973576696155 no 2766 0.158109231710741 4059 16452277
SGTC_3097 9117246 49.47 µM -1.0036975555573 0.192636336253547 no 2767 0.157762207832385 4105 16423892
SGTC_2792 7535235 81.82 µM -1.00380295872357 0.192611638796309 no 2768 0.157736798999786 4100 1281891
SGTC_3264 9137442 49.47 µM -1.00455978964398 0.192434359416116 no 2769 0.15755443380807 4102 17015726
SGTC_2842 9000675 19.48 µM -1.0054260758475 0.192231563825045 no 2770 0.157345864497104 4154 2989072
SGTC_1339 1486-1321 22.7 µM -1.0078681918563 0.191660574224294 no 2771 0.156758871785585 4110 3469382
SGTC_3047 9092122 49.47 µM -1.00808651482752 0.191609578899727 no 2772 0.156706465434905 4070 17173831
SGTC_95 0471-0001 561.058 µM -1.00896229906086 0.191405098994722 no 2773 0.156496357688077 4095 4015405
SGTC_2294 7971431 200 µM -1.01017049752076 0.191123225914817 no 2774 0.156206805669614 4085 5741572
SGTC_1460 k062-0059 9.15 µM -1.01101818886654 0.190925611278318 no 2775 0.156003862173772 3986 1373085
SGTC_1742 st038235 28.8875 µM -1.01110221227692 0.190906030488609 no 2776 0.155983755826355 4153 564103 YBR002C RER2
SGTC_365 0121-0052 13.6 µM -1.01112197039717 0.190901426241252 no 2777 0.155979028063151 4136 3101739
SGTC_2261 9010538 184.68 µM -1.01216060536573 0.190659488394012 no 2778 0.155730634355069 4108 6457250
SGTC_334 1502-1024 68.5 µM -1.01279630393495 0.190511502747311 no 2779 0.155578733253747 4126 3296216
SGTC_152 4469-0003 551.229 µM -1.01283128329401 0.190503361874158 no 2780 0.15557037772268 4004 697280
SGTC_2267 7931562 200 µM -1.0133474993786 0.190383245868498 no 2781 0.155447103434718 4033 934880
SGTC_2696 st077691 74.316 µM -1.01582974756689 0.189806312501745 no 2782 0.154855233803586 4167 757133
SGTC_356 1634-0012 32.5 µM -1.01632591671347 0.189691120079455 no 2783 0.154737105508946 4123 735457
SGTC_2774 tamoxifen 10.92 µM -1.01664701176197 0.189616596415599 no 2784 0.154660690717595 4095 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1802 st050112 57.9 µM -1.01716123194539 0.189497287434571 no 2785 0.154538367603881 4106 4662563
SGTC_1828 st055811 49 µM -1.02164462610928 0.188459011888089 no 2786 0.153474564076448 4141 5877589
SGTC_1985 st071382 65.5 µM -1.02324263997622 0.188089789596709 no 2787 0.153096568389932 4106 6123237
SGTC_2583 asiatic acid 100 µM -1.02327429133592 0.188082481038576 no 2788 0.153089087785232 4155 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_591 4299-0174 154 µM -1.02392724864166 0.187931746959103 no 2789 0.152934819384865 4123 5509088
SGTC_1365 1672-3266 55.4 µM -1.02409953959975 0.187891986325651 no 2790 0.152894130928875 4156 6415873
SGTC_965 1291-5240 308 µM -1.02486311880505 0.187715833034144 no 2791 0.152713889480828 4137 2834598
SGTC_2909 7941780 10.49 µM -1.0256836402952 0.187526657237947 no 2792 0.152520364071435 4087 1243215
SGTC_1968 st069590 43.6 µM -1.02712538282221 0.187194540970176 no 2793 0.152180713923916 4111 6384066
SGTC_2746 daunorubicin 9.88 µM -1.02807021546397 0.186977089064441 no 2794 0.151958399953557 4054 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1811 st050069 61.5 µM -1.03204367249989 0.186064315224394 no 2795 0.151025829560053 4058 3877702
SGTC_2103 5378138 10 µM -1.03404166635972 0.185606385949041 no 2796 0.150558342445648 4195 244142
SGTC_1757 st041620 31.8375 µM -1.03540004133985 0.185295453534567 no 2797 0.150241063212983 4192 5289815
SGTC_1729 st035615 45.989 µM -1.03712158884294 0.184901855827931 no 2798 0.149839597507452 4168 17385451
SGTC_599 1935-0052 86.5 µM -1.03735530285584 0.184848461836627 no 2799 0.149785150500943 4106 9557311
SGTC_2938 9059746 27.26 µM -1.03932113904277 0.184399728904313 no 2800 0.149327703367352 4132 6471769
SGTC_689 0833-0039 98 µM -1.04055787098785 0.18411777302837 no 2801 0.149040396164572 4085 5374726
SGTC_680 0417-1641 114 µM -1.04098792237103 0.184019790841017 no 2802 0.14894057681445 4107 2835990
SGTC_1270 0831-1170 17.3 µM -1.04303152089718 0.183554624595958 no 2803 0.148466847132398 4154 6764716
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.04791812806944 0.182445303982074 no 2804 0.147338164672348 4177 6708561
SGTC_75 0159-0059 199.013 µM -1.04946401025069 0.182095243338355 no 2805 0.146982305519345 4247 5377270
SGTC_2038 4100038 30.985 µM -1.04980619342727 0.18201781372288 no 2806 0.146903613578908 4127 3596803
SGTC_959 1222-0044 107 µM -1.05022093478278 0.181923993157795 no 2807 0.146808273306087 4153 6083612
SGTC_913 3487-1245 167 µM -1.05022380532332 0.181923343904912 no 2808 0.146807613574157 4074 4016153
SGTC_1030 k029-0042 36.7 µM -1.05077094959542 0.181799618414337 no 2809 0.146681900563325 4126 6080581
SGTC_296 1222-0039 74.9 µM -1.05096228838604 0.181756363483978 no 2810 0.146637955215316 4148 5984176
SGTC_2944 9067346 25.62 µM -1.05140109935081 0.181657188168284 no 2811 0.146537205567315 4098 6473075
SGTC_2602 kawain 100 µM -1.05277100134169 0.181347795631122 no 2812 0.146222979268483 4145 5369129
SGTC_405 ebelactone b 50 µM -1.05287725780116 0.181323811392802 no 2813 0.14619862522862 4107 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1972 st070201 17.4 µM -1.05412374784394 0.181042601641274 no 2814 0.145913132450286 4149 2829099
SGTC_308 4092-1169 104 µM -1.06060002358057 0.179585947216546 no 2815 0.144435855924173 4093 2268590 YDL196W YDL196W
SGTC_173 1273-0061 2.693 µM -1.06351912943124 0.178931792223121 no 2816 0.143773297412777 4134 2847414 YPL266W DIM1
SGTC_3255 9139072 49.47 µM -1.06474663490312 0.178657163676175 no 2817 0.143495300113988 4179 17646060
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.0647657341094 0.17865289272829 no 2818 0.143490977521312 4142 641818 YHR062C RPP1
SGTC_5 0352-0601 109.883 µM -1.0648398996115 0.178636308512819 no 2819 0.143474192984104 4077 762456
SGTC_882 0843-0131 351 µM -1.06520229387172 0.178555287144517 no 2820 0.143392197904958 4162 5425421
SGTC_1370 2001-0092 44.6 µM -1.06563994247942 0.178457471836082 no 2821 0.143293218013667 4213 790957
SGTC_2218 6965428 192.983 µM -1.06628094522539 0.178314267424488 no 2822 0.143148330253336 4043 675684
SGTC_570 0987-0065 62.6 µM -1.0663225171417 0.178304982474232 no 2823 0.143138937047671 3936 3104428
SGTC_678 1218-2179 85.9 µM -1.06843474221357 0.177833625010565 no 2824 0.142662226193945 4165 6820081 YOR116C RPO31
SGTC_1795 st049545 62.3 µM -1.07392206260597 0.176612769285144 no 2825 0.141428807038067 4123 5291882
SGTC_2523 spermine 47.74 µM -1.07716716156154 0.175893278052453 no 2826 0.140702796483448 4195 1103 A DNA binding polyamine.
SGTC_1843 st055809 45.5 µM -1.0781777054863 0.175669603592166 no 2827 0.140477229639409 4225 16413835
SGTC_2455 5377712 9.75 µM -1.07849707025357 0.175598952677287 no 2828 0.140405994257847 4170 2243908
SGTC_450 aminopyrene 156 nM -1.08504383980665 0.174154624376881 no 2829 0.138951119467633 4107 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_603 3794-0023 45.9 µM -1.08563268219253 0.174025086910344 no 2830 0.138820767211214 4224 3802260
SGTC_1910 st062352 60.4 µM -1.0876750668546 0.173576264387801 no 2831 0.138369289261938 4078 2245730
SGTC_523 1934-0222 13.7 µM -1.08801747536502 0.173501090854176 no 2832 0.138293696448971 4123 1361595
SGTC_819 1013-0258 27.7 µM -1.08803011851757 0.173498315530016 no 2833 0.138290905785578 4180 5753198
SGTC_407 eburnamonine 100 µM -1.08852635059374 0.173389408934229 no 2834 0.138181405142337 4022 3195
SGTC_1508 1080-0625 72.9 µM -1.08960281660836 0.173153309732322 no 2835 0.137944070915333 4077 767111
SGTC_2384 9036245 200 µM -1.08992692090557 0.173082264689016 no 2836 0.137872668399678 4108 6462766
SGTC_3217 9129673 49.47 µM -1.09074857990784 0.172902236753338 no 2837 0.137691763995682 4218 17248312
SGTC_2722 naftopidil 47.16 µM -1.0931815774412 0.172369859808835 no 2838 0.137157042000491 4116 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2767 sibutramine 71.45 µM -1.09366013144395 0.172265268095889 no 2839 0.137052033012214 4214 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1045 1348-1485 165 µM -1.09533782201173 0.171898915629821 no 2840 0.136684331702715 4169 6810614
SGTC_2528 xanthyletin 44.79 µM -1.09544479387532 0.171875573375154 no 2841 0.1366609094568 4217 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1014 4130-3005 69.3 µM -1.09560097278909 0.171841497319798 no 2842 0.136626717907868 4197 743608
SGTC_865 0488-0499 301 µM -1.0977135521106 0.171380985985104 no 2843 0.136164795080864 4161 9634651
SGTC_2032 5185112 25.99 µM -1.09780416531707 0.171361251293264 no 2844 0.136145006121385 4073 5718189
SGTC_1499 4480-0877 67.3 µM -1.10125080716751 0.17061168419683 no 2845 0.135393757325505 4132 2861909
SGTC_537 1334-0398 209 µM -1.10229990742026 0.170383945813709 no 2846 0.13516565480453 4250 5846986
SGTC_656 4090-1979 187 µM -1.10289926787934 0.17025392425263 no 2847 0.135035456106508 4254 22330961
SGTC_31 0508-1974 57.237 µM -1.10454172491595 0.169897945633998 no 2848 0.134679107096095 4130 6810525
SGTC_1756 st041558 35.5 µM -1.10525747292548 0.169742967083545 no 2849 0.134524019813386 4280 3955792
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.10670133313789 0.169430608825538 no 2850 0.134211539404647 4305 5282309
SGTC_208 k072-0098 12.366 µM -1.10677416610268 0.169414862246772 no 2851 0.13419579010481 4177 5948901
SGTC_2801 7907800 81.82 µM -1.10809516541959 0.169129423538745 no 2852 0.133910359338125 4216 6620925
SGTC_2014 4013930 200 µM -1.10814141213742 0.169119436244946 no 2853 0.133900374288955 4175 64556
SGTC_2657 nystatin 74.44 µM -1.1102688335578 0.168660414542081 no 2854 0.133441599500571 4227 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1490 4089-0339 670 nM -1.11171480249796 0.168348883530844 no 2855 0.133130396635123 4176 742542
SGTC_2295 7971645 200 µM -1.11200882889052 0.168285581460704 no 2856 0.133067177144284 4263 2978226 YKL099C UTP11
SGTC_1078 idebenone 36.1 µM -1.11223289021361 0.168237352719395 no 2857 0.13301901492688 4248 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2364 9055074 200 µM -1.11324357830824 0.168019914699751 no 2858 0.132801915606244 4223 6470630
SGTC_2781 5567276 71.43 µM -1.11346631235394 0.167972020341312 no 2859 0.132754104388649 4236 2853274
SGTC_2676 harmalol 100 µM -1.11371060041236 0.167919501342271 no 2860 0.132701680103627 4162 5459187 A monoamine oxidase inhibitor
SGTC_1946 st076057 65.1 µM -1.11489349815984 0.167665342063511 no 2861 0.132448031622056 4141 953009
SGTC_732 3970-1727 52.7 µM -1.1194613690353 0.166686209137829 no 2862 0.131471681301359 4283 1275699
SGTC_2820 7989630 71.43 µM -1.11957407943964 0.166662096159508 no 2863 0.131447653219228 4231 2984098
SGTC_677 0929-0063 136 µM -1.12073136901649 0.166414638788852 no 2864 0.131201112690531 4194 1539583
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.12094681846352 0.166368596530871 no 2865 0.131155250197957 4197 140250 A respiratory chain inhibitor.
SGTC_756 0508-1999 28.3 µM -1.12102954555964 0.16635091966315 no 2866 0.13113764311245 4230 6753853
SGTC_889 0919-1524 82.7 µM -1.12185666792753 0.166174249422818 no 2867 0.130961693650923 4236 3905452
SGTC_457 grayanotoxin iii 135 µM -1.12643487601201 0.16519855439841 no 2868 0.129990745769786 4060 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_641 4092-0595 30 µM -1.12775624907769 0.164917637956546 no 2869 0.129711437534176 4250 786260
SGTC_1166 k206-0078 225 µM -1.12922022767514 0.16460676583555 no 2870 0.129402471387156 4233 5404595
SGTC_1550 gossypolone 36.6 µM -1.1296684925382 0.164511653921061 no 2871 0.129307969154736 4244 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2211 7117706 200 µM -1.13004734345078 0.164431297893618 no 2872 0.129228137925779 4137 822771
SGTC_2552 juarezic acid 87.02 µM -1.13051225932865 0.164332721865205 no 2873 0.129130217835963 4183 1549512
SGTC_112 phenothiazine 287.218 µM -1.13052276554014 0.164330494677906 no 2874 0.129128005623351 4188 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2033 5192550 145 µM -1.13256881774114 0.163897129876642 no 2875 0.128697684797859 4227 182073
SGTC_3008 9078912 71.4286 µM -1.13533547798706 0.163312316941277 no 2876 0.128117391300488 4226 16648731
SGTC_2478 5763493 32.33 µM -1.13573798793024 0.16322734803106 no 2877 0.128033118477132 4156 1365576 YLR208W SEC13
SGTC_1560 lithocholic acid 53.1 µM -1.13630827977144 0.163107009944818 no 2878 0.127913783386652 4140 9903 A bile acid which acts as a detergent.
SGTC_864 0469-0573 172 µM -1.13909874860376 0.162519020748146 no 2879 0.127330984700375 4214 689425
SGTC_1830 st055982 50.3 µM -1.14029244076591 0.162267915532881 no 2880 0.127082243027316 4194 455313 An antimicrobial agent.
SGTC_2159 5658611 73.75 µM -1.14064114619657 0.162194609515193 no 2881 0.127009643621142 4227 793844
SGTC_2309 7664088 163.95 µM -1.14694784826011 0.160872515997673 no 2882 0.125701587786343 4245 704922
SGTC_153 4077-0274 519.67 µM -1.14703131873217 0.160855065129259 no 2883 0.125684338653783 4282 3121976
SGTC_3116 9124943 49.47 µM -1.14774431309201 0.160706052354205 no 2884 0.12553706601076 4220 41905195 YPL160W CDC60
SGTC_2809 7964133 12.99 µM -1.15045819483116 0.160139687527833 no 2885 0.124977601562204 4243 1253665
SGTC_3337 9144342 33.5465 µM -1.15102209184107 0.160022170791608 no 2886 0.124861573548359 4229 17682949
SGTC_1650 st011916 45.8 µM -1.1510620159947 0.160013852693759 no 2887 0.124853361568416 4169 242528
SGTC_3139 9095020 49.47 µM -1.15207161012636 0.159803600255899 no 2888 0.124645824057795 4043 25236292
SGTC_2702 st077768 96.8 µM -1.15330892016744 0.159546171562506 no 2889 0.124391805063583 4233 6484119
SGTC_2240 6690706 185.951 µM -1.15495895671337 0.159203295582553 no 2890 0.124053617167625 4116 805876
SGTC_1096 rimcazole 32.2 µM -1.15689842780614 0.158800892884609 no 2891 0.123656930574485 4165 18528119 A dopamine reuptake inhibitor.
SGTC_931 2812-0076 566 µM -1.15818133082723 0.158535082029759 no 2892 0.123395022658011 4194 3450959
SGTC_1835 st008666 49.2 µM -1.15967636794234 0.158225686468682 no 2893 0.123090297645543 4184 690455
SGTC_2817 7995342 71.43 µM -1.16095732770182 0.15796090928482 no 2894 0.122829626721382 4256 18879975
SGTC_1867 st057372 64 µM -1.16290930051029 0.157557991975162 no 2895 0.122433151777458 4213 688837
SGTC_861 0443-0273 110 µM -1.16411680709514 0.157309082371253 no 2896 0.122188339178924 4245 6149169
SGTC_2665 lovastatin 100 µM -1.16522080108801 0.157081736698348 no 2897 0.121964813889627 4277 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_855 0428-0020 25 µM -1.16794290196107 0.156522097754681 no 2898 0.121414898620058 4277 6812414
SGTC_3096 9117468 49.47 µM -1.16936968885036 0.156229288495302 no 2899 0.121127358328786 4163 41316311
SGTC_3298 9116858 71.43 µM -1.16944507702684 0.156213827163425 no 2900 0.121112178688041 4317 2506942
SGTC_1625 st003711 30.1 µM -1.17209543078633 0.155670907841579 no 2901 0.120579372099093 4325 24207034 YER133W GLC7
SGTC_246 cycloheximide 667 µM -1.17308108573442 0.15546931636425 no 2902 0.120381645312442 4155 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1919 st067113 52.3 µM -1.17444056351744 0.155191551356613 no 2903 0.120109302889862 4286 1268243
SGTC_1758 st042942 75.2445 µM -1.17472431546692 0.155133617236867 no 2904 0.120052514042699 4230 669317
SGTC_2571 chrysanthemic acid 100 µM -1.17482769466545 0.15511251367859 no 2905 0.120031828895772 4252 2743 An insecticide.
SGTC_1321 1326-2144 215 µM -1.17767849740951 0.154531305114006 no 2906 0.119462401195464 4263 3513030
SGTC_3173 9105693 49.47 µM -1.17843677134392 0.154376954381955 no 2907 0.119311262747221 4275 17096658
SGTC_2231 micatex 6.853 µM -1.18079099056736 0.153898390140166 no 2908 0.118842882006052 4280 20737 An antifungal of unknown mechanism.
SGTC_1876 myriocin 605 nM -1.18130581637736 0.153793867629966 no 2909 0.118740628772754 4264 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1197 1601-0112 267 µM -1.18249513340127 0.153552586238329 no 2910 0.11850464769666 4240 7350313
SGTC_2015 5119600 184 µM -1.1847572689079 0.153094350179745 no 2911 0.11805671606144 4299 2828786
SGTC_3262 9137218 49.47 µM -1.1877794315058 0.152483572773467 no 2912 0.117460159971698 4205 17650664
SGTC_2427 5545055 42.75 µM -1.19518802077979 0.150993150346495 no 2913 0.116006788905333 4211 5372858
SGTC_2798 7813637 45.45 µM -1.19590016167142 0.15085039794249 no 2914 0.115867761035953 4275 956368
SGTC_890 0929-0006 47.2 µM -1.1978066818826 0.150468668246259 no 2915 0.115496142660183 4270 1378169
SGTC_2468 5987765 72.9 µM -1.1991460948201 0.150200871803189 no 2916 0.115235571663711 4323 26772094
SGTC_2203 7227154 166.4 µM -1.20021188820436 0.149988008765948 no 2917 0.115028529718049 4299 896304
SGTC_843 0310-0051 143 µM -1.20026621345974 0.149977164174535 no 2918 0.115017983537043 4309 2065037
SGTC_3260 9137109 49.47 µM -1.20058008258809 0.149914518793383 no 2919 0.114957065475258 4231 17478346
SGTC_3241 9133421 49.47 µM -1.20180459362029 0.149670284554621 no 2920 0.114719622648795 4357 17018221
SGTC_536 3852-0578 10.6 µM -1.20333710919736 0.149364991660508 no 2921 0.114422947128778 4334 2869208
SGTC_1817 st052116 64.4 µM -1.20353410490747 0.149325778260701 no 2922 0.114384850919247 4310 4361398
SGTC_10 0279-0212 42.575 µM -1.203665942292 0.14929953892936 no 2923 0.114359360461238 4272 39851 YBR002C RER2
SGTC_2012 4023501 200 µM -1.20489771302073 0.149054530812722 no 2924 0.114121395803673 4301 3477460
SGTC_899 1083-0020 478 µM -1.20699414516263 0.148638153152186 no 2925 0.113717199380084 4351 767123
SGTC_1184 1269-1718 139 µM -1.20784930924916 0.148468530359349 no 2926 0.113552615354821 4331 5403821
SGTC_85 0868-0259 160.055 µM -1.21299081041698 0.147451437096095 no 2927 0.112566666984687 4202 83173
SGTC_2690 usnic acid 100 µM -1.21320927551778 0.147408323913051 no 2928 0.11252490936715 4329 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3127 9126946 49.47 µM -1.22000937362778 0.146070575844495 no 2929 0.111230660750981 4281 27243249
SGTC_3251 9135047 49.47 µM -1.22082801514665 0.145910080503013 no 2930 0.111075572104256 4333 17682963
SGTC_1465 k213-0056 144 µM -1.22139327906273 0.145799329236265 no 2931 0.110968575339585 4197 24048857 YMR208W ERG12
SGTC_1000 4048-0884 8.67 µM -1.22142478526066 0.145793157939505 no 2932 0.110962613818042 4339 13040088
SGTC_2301 7769476 200 µM -1.2215598603527 0.145766702009031 no 2933 0.110937057857443 4309 977820
SGTC_3081 9117243 49.47 µM -1.22164084648217 0.145750841539489 no 2934 0.110921737451614 4279 45595589
SGTC_425 3825-7017 13.1 µM -1.22330402989565 0.145425377236169 no 2935 0.11060744282209 4355 3397440
SGTC_2519 cryptotanshinone 88.04 µM -1.22453442146131 0.145184919726945 no 2936 0.11037534472688 4289 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2453 5731132 22.18 µM -1.22453512013395 0.145184783260217 no 2937 0.110375213030243 4349 1362040
SGTC_2133 5320837 200 µM -1.22699125565421 0.144705577354682 no 2938 0.109912938764513 4337 2841355
SGTC_1243 0416-0003 5.65 µM -1.22708780748536 0.144686761334845 no 2939 0.109894794973025 4299 2141977
SGTC_848 0368-0089 85.6 µM -1.2280924068297 0.144491082802478 no 2940 0.109706140561437 4299 762535
SGTC_2195 6536160 144.242 µM -1.22852535227871 0.144406807544947 no 2941 0.109624909162793 4285 3834386
SGTC_850 0388-0143 75.9 µM -1.23100206138031 0.143925339087724 no 2942 0.109161046653004 4291 67273
SGTC_2679 rapamycin 1 nM -1.23128634173213 0.143870144778388 no 2943 0.109107894194931 4206 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2895 9054447 58.44 µM -1.23263217151225 0.143609039699316 no 2944 0.108856514194659 4378 2697450
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.23550938517784 0.143051903440266 no 2945 0.108320492877133 4364 23665772 A membrane-active detergent.
SGTC_2481 5478948 45.16 µM -1.23767223857417 0.142634056792636 no 2946 0.107918808440181 4333 77792
SGTC_2110 5483698 200 µM -1.23816183984413 0.142539584258921 no 2947 0.107828028939274 4297 2848765 YHR062C RPP1
SGTC_1398 3558-0053 112 µM -1.24195281402547 0.141809517565293 no 2948 0.107126986093053 4262 4532369
SGTC_884 0851-0618 334 µM -1.24509927421173 0.141205497886869 no 2949 0.106547630447216 4338 9642473
SGTC_124 0136-0217 7.121 µM -1.24894904471432 0.140468841014954 no 2950 0.105841855794177 4382 3976905
SGTC_2013 4024628 200 µM -1.24940756771293 0.140381276451349 no 2951 0.105758020951708 4357 5230760
SGTC_1509 1326-1131 80 µM -1.2566913578976 0.138995254759968 no 2952 0.104432709346571 4306 768313
SGTC_2027 5150920 200 µM -1.26193906578528 0.138002468958071 no 2953 0.103485356701556 4269 786715
SGTC_3061 glucosamine 200 µM -1.2635393721994 0.137700680246706 no 2954 0.103197703164 4281 91431 and experimental redox chemotherapeutic
SGTC_1046 2001-0062 216 µM -1.26596797132505 0.137243551518777 no 2955 0.10276227467971 4267 739778
SGTC_1821 st053465 65.6 µM -1.27064573813954 0.136365991605589 no 2956 0.101927353786719 4357 675086
SGTC_583 1488-1091 88.9 µM -1.27143489019687 0.136218324131772 no 2957 0.101786988422649 4443 4303273
SGTC_101 0490-5701 117.494 µM -1.27564727478189 0.135431946842754 no 2958 0.101040117289097 4205 4661669
SGTC_618 k072-0232 33.2 µM -1.27934370726221 0.134744456236295 no 2959 0.100388023825453 4393 5872756 YGL099W LSG1
SGTC_317 4495-0002 170 µM -1.28221743394766 0.134211635977291 no 2960 0.0998831910608425 4377 15991618
SGTC_350 k064-0020 19.8 µM -1.28437715925859 0.133812153075513 no 2961 0.0995050104308883 4371 2790705
SGTC_297 0986-0032 24 µM -1.28682038558817 0.133361217387863 no 2962 0.0990784499184121 4330 2847425
SGTC_3329 9141233 27.5565 µM -1.28721687054016 0.133288138584522 no 2963 0.0990093543162043 4320 4909101 YNL103W MET4
SGTC_1769 st044406 64.4 µM -1.28766023898899 0.133206451006858 no 2964 0.0989321300610737 4330 670903
SGTC_1574 spiramycin 23.7 µM -1.28952129115717 0.132863940823621 no 2965 0.0986084596427132 4320 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1337 1486-1011 40.3 µM -1.28984640424544 0.132804168913795 no 2966 0.0985519962595796 4323 X1337
SGTC_97 0535-0701 19.132 µM -1.28992837213234 0.132789102074246 no 2967 0.0985377643830145 4249 2832013 YGL099W LSG1
SGTC_118 0083-0097 135.343 µM -1.2904447808181 0.132694206033858 no 2968 0.0984481362503107 4333 5207356
SGTC_1682 st012968 530 nM -1.29136616556457 0.132525007024845 no 2969 0.0982883685770867 4363 24207270
SGTC_1681 tripelennamine 100 µM -1.29469743760726 0.131914507587726 no 2970 0.0977123121253568 4278 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3070 9117005 49.47 µM -1.29817354643409 0.131279536090253 no 2971 0.0971138530697325 4461 8779016
SGTC_2698 st077697 67.5 µM -1.2995999714421 0.131019586618393 no 2972 0.0968690547424959 4328 3154499
SGTC_609 0986-0026 86.3 µM -1.30462922842413 0.130105901101765 no 2973 0.0960095653192938 4336 2848610
SGTC_1810 st050138 53 µM -1.30639882560973 0.129785462452349 no 2974 0.0957084825095794 4379 3444541
SGTC_3104 9120930 49.47 µM -1.3080329492052 0.129490041079896 no 2975 0.0954310669020563 4390 17014836
SGTC_50 0929-0078 56.389 µM -1.30958967863659 0.129209044867163 no 2976 0.0951673409793783 4220 1377751
SGTC_1602 st001878 87.6 µM -1.30978199993096 0.129174359422268 no 2977 0.0951347970662429 4351 595405 YLR310C CDC25
SGTC_1281 0884-0031 11.8 µM -1.31138251322981 0.1288859547335 no 2978 0.0948642818669541 4395 1548255
SGTC_1245 0418-0076 17.2 µM -1.31340444793239 0.128522250884016 no 2979 0.0945233497552705 4395 6790114
SGTC_2050 5263056 171 µM -1.31447045061569 0.128330786302991 no 2980 0.0943439678983043 4356 763468 YGL055W OLE1
SGTC_2968 9090663 33.37 µM -1.3146659289777 0.128295697962478 no 2981 0.0943111009875936 4329 25236811
SGTC_2517 totarol 10 µM -1.31823311052497 0.127656559104426 no 2982 0.093712812375264 4370 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2136 5328288 199.296 µM -1.32045149549313 0.127260204828968 no 2983 0.0933421601292626 4364 262395
SGTC_3151 9099821 49.47 µM -1.32591693414973 0.126287361488096 no 2984 0.0924336065768902 4325 17174189
SGTC_2884 9058502 51.95 µM -1.32620344149497 0.126236506784182 no 2985 0.0923861598362555 4398 6471554
SGTC_2703 st077852 53.4 µM -1.32698509357529 0.126097837087397 no 2986 0.0922568068438832 4410 6281836
SGTC_2114 5491910 81.25 µM -1.32759067552088 0.125990476304368 no 2987 0.0921566833058931 4422 2849228
SGTC_1774 st048371 48.465 µM -1.32805990795513 0.125907332124425 no 2988 0.092079158364252 4364 4242727
SGTC_126 0417-1624 672.48 µM -1.32941514492356 0.125667410009987 no 2989 0.09185552198616 4439 41912 YDL195W SEC31
SGTC_479 n-linoleoylglycine 10 µM -1.33153960064506 0.125291952778293 no 2990 0.0915057618796965 4425 6433346 An anti-infammatory.
SGTC_596 1155-0152 116 µM -1.33158873622403 0.125283278273218 no 2991 0.0914976841302932 4414 280313
SGTC_1881 5652484 16 µM -1.33299343244156 0.125035467380821 no 2992 0.0912669795296871 4372 2255129
SGTC_624 k048-0052 28 µM -1.33847242803877 0.124072157869457 no 2993 0.0903712412290299 4372 6835531
SGTC_658 3253-0951 102 µM -1.33873645891776 0.124025867833749 no 2994 0.0903282413800664 4397 1184878
SGTC_2093 5331342 194.4 µM -1.34117158639401 0.123599509652111 no 2995 0.0899323746328437 4438 33839
SGTC_427 1354-0053 47.3 µM -1.34354506351188 0.123184934401047 no 2996 0.0895477722549081 4439 6813657
SGTC_3280 9140961 49.47 µM -1.3439801575902 0.123109042339054 no 2997 0.0894774017102326 4427 4901226
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.34876162098969 0.122277185625611 no 2998 0.0887067728490411 4438 65057 A dermal irritant. YDR527W RBA50
SGTC_2865 9030313 51.95 µM -1.35617400660051 0.120995426871409 no 2999 0.0875219051717596 4384 42562754
SGTC_1731 st035964 63 µM -1.36088644039292 0.120185479046197 no 3000 0.0867747896300742 4320 6739575
SGTC_3041 9091929 49.47 µM -1.36385997431983 0.119676374047791 no 3001 0.0863058200978995 4399 25236887
SGTC_2618 avocadyne 43.43 µM -1.37373519587701 0.117996536116128 no 3002 0.0847619530349931 4341 3015189
SGTC_3328 9140624 29.0385 µM -1.37478289518342 0.117819299358876 no 3003 0.0845993812841991 4420 4904392
SGTC_3265 9137266 49.47 µM -1.37497213535306 0.117787306153507 no 3004 0.084570041796131 4385 17224265
SGTC_1049 3226-0134 66 µM -1.37898705076355 0.117109987383428 no 3005 0.0839493732318284 4451 5702385
SGTC_2799 7812892 81.82 µM -1.38392431034402 0.116280857808231 no 3006 0.0831908160331061 4441 20205235
SGTC_2858 9025781 8.96 µM -1.38749730411565 0.115683437239894 no 3007 0.0826450863045851 4276 4894980 YPL153C RAD53
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.39080314843898 0.115132630005043 no 3008 0.0821425640620451 4475 165506
SGTC_290 2043-6722 48.1 µM -1.39190033054 0.114950234485102 no 3009 0.0819762908771463 4449 773758 YLR208W SEC13
SGTC_2424 5537928 59.2 µM -1.39336030701521 0.114707846858467 no 3010 0.0817554312011641 4433 5382802
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.39667263152244 0.114159278517783 no 3011 0.0812560189474262 4437 688667
SGTC_2275 7947463 200 µM -1.39738522298348 0.11404150780801 no 3012 0.0811488801843546 4386 1225414
SGTC_765 1319-0117 244 µM -1.39882510171018 0.113803801795541 no 3013 0.0809327184931082 4401 3487746 YGL099W LSG1
SGTC_254 nsc-64875 3.808 µM -1.40116552970632 0.113418180172627 no 3014 0.0805822897658608 4432 56993
SGTC_1328 1441-0025 69.2 µM -1.40355334730277 0.113025711698469 no 3015 0.0802259478216669 4420 4562601
SGTC_574 1315-0397 40 µM -1.40435290005312 0.112894511801923 no 3016 0.0801068944593785 4420 6794277
SGTC_1404 3909-7820 48.3 µM -1.40512259110022 0.112768314696022 no 3017 0.0799924137169223 4428 23741373
SGTC_1889 st059080 5.18 µM -1.40575456364546 0.112664772985471 no 3018 0.0798985091859926 4420 176925 Isolated from Daphnopsis sellowiana.
SGTC_616 4092-0450 108 µM -1.40682967428362 0.112488784026916 no 3019 0.0797389505295781 4442 787165
SGTC_117 lucigenin 22.078 µM -1.41084579357428 0.111833107325081 no 3020 0.079145044199679 4423 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3165 9101544 49.47 µM -1.41101851388289 0.111804970221715 no 3021 0.0791195775365192 4437 5002184
SGTC_287 k060-0039 29.6 µM -1.41198931048066 0.111646916237191 no 3022 0.0789765543403624 4476 5861974
SGTC_198 3454-2873 16.191 µM -1.4122391614756 0.111606264236198 no 3023 0.0789397765962893 4451 710957
SGTC_504 lovastatin 124 µM -1.41315470715242 0.111457390903602 no 3024 0.0788051203182443 4447 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3316 9136639 10.545 µM -1.41381226873599 0.111350555091993 no 3025 0.0787085151614932 4428 4903665
SGTC_3334 9142812 21.919 µM -1.41491709756884 0.11117121564388 no 3026 0.0785464021832448 4448 45283678
SGTC_2716 st080858 38.6235 µM -1.41550397874627 0.111076035314965 no 3027 0.0784603913356243 4420 5296050
SGTC_236 1509-0011 5.31 µM -1.41991631396626 0.110362311600715 no 3028 0.0778160229350592 4481 3107280
SGTC_823 0417-1665 178 µM -1.42171526372533 0.110072265549872 no 3029 0.0775544636007356 4457 3429856
SGTC_3042 9091578 49.47 µM -1.42206767348644 0.110015510371088 no 3030 0.0775033030679658 4439 25236497
SGTC_1227 3909-8010 46.6 µM -1.42437874210596 0.109643835776295 no 3031 0.077168432247194 4437 15982272
SGTC_382 3229-0966 23.2 µM -1.42907784321436 0.108890890953412 no 3032 0.0764909305045589 4490 5722370
SGTC_1189 1431-2119 7.28 µM -1.4299297808442 0.108754782575637 no 3033 0.0763685868110608 4429 3107275
SGTC_2539 epi(13)torulosol 80 µM -1.43306336325589 0.108255203702568 no 3034 0.075919865122757 4424 6708597
SGTC_245 methotrexate 289.6 µM -1.43330074672656 0.108217425686256 no 3035 0.0758859543440042 4410 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2917 7979103 53.79 µM -1.4336025256102 0.108169413264695 no 3036 0.0758428611854606 4450 2980565
SGTC_1325 1431-0015 227 µM -1.43415920667179 0.108080886647368 no 3037 0.0757634176290828 4467 1103340
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.43733532928624 0.107576799088797 no 3038 0.0753113674305588 4442 688803
SGTC_1629 st005085 44.9 µM -1.43776338055399 0.107508992139886 no 3039 0.0752506014334841 4417 24207091
SGTC_1152 3909-8331 15.9 µM -1.43789688026105 0.107487850957218 no 3040 0.0752316575139872 4433 16001939
SGTC_2068 5226020 147 µM -1.43902174071662 0.107309835605297 no 3041 0.0750721815529048 4471 1810509
SGTC_1109 tnp00067 928.257 nM -1.44072914402511 0.107040035955748 no 3042 0.0748306089853572 4465 676295
SGTC_2437 5741531 144.16 µM -1.44143937567986 0.106927951113432 no 3043 0.0747302964406953 4475 2262990
SGTC_2640 pentamidine 10.38 µM -1.44175777553708 0.106877730500987 no 3044 0.0746853592276298 4419 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.44312104511795 0.106662896962614 no 3045 0.0744931879546189 4415 676296 Flavone; oxidizing agent.
SGTC_3342 9147791 14.508 µM -1.44655699518225 0.106122819074839 no 3046 0.0740105190820017 4417 1838168
SGTC_1015 4130-4525 82 µM -1.44698093961922 0.10605631876892 no 3047 0.0739511309947918 4476 1363237
SGTC_62 0180-0423 3.232 µM -1.44771485372274 0.105941267529075 no 3048 0.0738484070214008 4425 30102 YGL099W LSG1
SGTC_2915 7971052 15.16 µM -1.44809737631651 0.10588133756291 no 3049 0.073794909617114 4401 5741558
SGTC_147 4466-0538 29.23 µM -1.4509507480805 0.105435071620184 no 3050 0.0733967876191127 4518 6742687 YHR072W ERG7
SGTC_812 4251-0442 148 µM -1.45386967332789 0.104979962502846 no 3051 0.072991221096011 4495 5723007
SGTC_2986 9022445 71.43 µM -1.45471188275604 0.104848912748121 no 3052 0.0728745207649045 4444 6459286
SGTC_933 2914-0560 114 µM -1.45529703041368 0.104757932169346 no 3053 0.0727935242020397 4482 463887
SGTC_106 0092-0003 11.579 µM -1.45596183366318 0.104654635881742 no 3054 0.0727015853138835 4374 1072148
SGTC_826 1683-5028 118 µM -1.45704754308718 0.104486098382636 no 3055 0.0725516284816515 4510 722377
SGTC_651 3253-0966 34.4 µM -1.45950805670956 0.104104874452316 no 3056 0.0722126623903025 4485 781462
SGTC_859 0439-0102 54.6 µM -1.45980089719356 0.10405956994374 no 3057 0.0721724009613633 4517 610143
SGTC_2244 6635614 200 µM -1.46310943090655 0.103548709046033 no 3058 0.0717187188444438 4425 836499
SGTC_3020 9089140 49.47 µM -1.46694976522793 0.102958019709267 no 3059 0.0711948606563649 4492 17217859
SGTC_57 miconazole 162.5 nM -1.46730524934038 0.102903466035987 no 3060 0.0711465181864277 4306 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3174 9107204 49.47 µM -1.4682186018196 0.102763396490677 no 3061 0.0710224264818922 4481 3938802
SGTC_312 4092-0653 6.84 µM -1.4692078296899 0.102611847231413 no 3062 0.0708882136324051 4373 1148278
SGTC_601 0986-0029 62.9 µM -1.47444904265021 0.101811605964561 no 3063 0.0701803640899486 4448 24747981
SGTC_1776 st049249 45.9 µM -1.47979135187951 0.10100061411196 no 3064 0.0694644686575919 4495 1822314
SGTC_1419 3993-2473 62.6 µM -1.48084635112311 0.100841017781225 no 3065 0.0693237609279113 4560 704026
SGTC_2297 7971671 152.32 µM -1.48635998764971 0.100009926659346 no 3066 0.0685919636907392 4481 909016
SGTC_3275 9138069 49.47 µM -1.48672213548785 0.0999555143261421 no 3067 0.0685441069571602 4536 17617007
SGTC_2943 9068529 45.32 µM -1.48748572025484 0.0998408573712366 no 3068 0.0684432859646688 4448 3270634
SGTC_1691 st019933 84.6 µM -1.49097466620198 0.0993181928440341 no 3069 0.0679840731509976 4479 6176082
SGTC_779 1360-0071 233 µM -1.49684026607272 0.0984440049770041 no 3070 0.06721741308051 4513 7566
SGTC_2002 4023503 131 µM -1.49846175937837 0.0982033404584152 no 3071 0.0670066604407719 4484 4736863 YCR052W RSC6
SGTC_963 1269-2853 151 µM -1.50337268101121 0.0974770836760387 no 3072 0.0663714836421549 4487 3668223
SGTC_569 4130-2812 160 µM -1.50895665439518 0.0966560871703036 no 3073 0.0656549300872034 4369 743552
SGTC_1085 doxorubicin 7.67 µM -1.51062348222016 0.0964120051045835 no 3074 0.0654422038255157 4506 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2299 7976368 114.88 µM -1.51141122681087 0.0962968093965594 no 3075 0.0653418553693128 4498 2979718
SGTC_1939 st074455 53.6 µM -1.51230761078349 0.096165849912156 no 3076 0.0652278128995503 4448 1644229
SGTC_311 1315-0136 58 µM -1.51503756847867 0.0957678164633047 no 3077 0.0648814452072742 4530 6759207
SGTC_2280 7785178 200 µM -1.51894878581095 0.0951996669109437 no 3078 0.0643876938381232 4491 2954328
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.52063421128952 0.0949556060604253 no 3079 0.0641758282950381 4506 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2362 9071156 126 µM -1.52149979042104 0.0948304437227736 no 3080 0.0640672319342849 4505 653133
SGTC_1614 st002383 48.6 µM -1.52525243721756 0.0942892185742697 no 3081 0.0635980730272434 4536 1947235
SGTC_1524 corynanthine 62.1 µM -1.52670692449925 0.0940800590540176 no 3082 0.063416952387983 4573 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_612 0302-0167 22.4 µM -1.52685755111898 0.0940584180828782 no 3083 0.0633982185103154 4508 235821
SGTC_299 1273-0059 1.44 µM -1.5285502567505 0.0938154745854668 no 3084 0.0631879878080085 4289 2848077
SGTC_2988 9073640 71.4286 µM -1.52962611045117 0.0936613049459423 no 3085 0.0630546513143944 4521 9102229
SGTC_2675 theaflavin digallate 100 µM -1.53627411200643 0.0927127949312656 no 3086 0.062235582992564 4441 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1949 st076024 69.1 µM -1.54213516084185 0.0918824729207474 no 3087 0.0615203761302237 4480 2921930
SGTC_2836 9010338 19.48 µM -1.54607290242801 0.0913277230032352 no 3088 0.0610434811175996 4477 2994051
SGTC_560 2332-1943 155 µM -1.54827279312321 0.0910188850187087 no 3089 0.0607783159803053 4514 21177716
SGTC_2623 humulene 100 µM -1.54852752461968 0.0909831739091364 no 3090 0.0607476700467521 4499 6187145 An anti-inflammatory.
SGTC_2460 5552655 174.22 µM -1.55158061664426 0.0905559658507221 no 3091 0.0603813020311742 4500 5401989
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.55476789197804 0.0901115726253206 no 3092 0.0600006793158742 4501 521171
SGTC_1690 st023502 41.2 µM -1.55573169353173 0.0899775119301373 no 3093 0.0598859533959194 4527 24207482
SGTC_2190 6049624 200 µM -1.5627111506961 0.0890111189719336 no 3094 0.0590602752261434 4438 2265554
SGTC_1483 3453-0561 55.9 µM -1.56302502406151 0.0889678415305903 no 3095 0.0590233545119738 4556 4546991
SGTC_1267 0828-0272 9.49 µM -1.56595480549031 0.0885646330640976 no 3096 0.0586795989808573 4575 745334
SGTC_559 1550-0661 158 µM -1.56677840147162 0.0884515319193111 no 3097 0.0585832487842563 4570 5830875
SGTC_342 k048-0088 23.3 µM -1.5674177588411 0.0883638057508222 no 3098 0.0585085378201253 4531 6820570
SGTC_2759 disulfiram 3.38 µM -1.57602399659825 0.0871892477194861 no 3099 0.0575101365342694 4443 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1613 st002381 52.1 µM -1.57768295079011 0.0869641841552701 no 3100 0.0573192324975162 4537 551167
SGTC_953 1188-0045 9.7 µM -1.58049969424235 0.086583042459918 no 3101 0.0569962384318275 4511 6144426
SGTC_1222 0366-0074 1.18 µM -1.58189999031971 0.0863940296549338 no 3102 0.0568362015826908 4545 286520
SGTC_1233 0325-0408 14.2 µM -1.58247602482258 0.0863163657999532 no 3103 0.0567704706519891 4570 12874
SGTC_386 1509-0011 3.07 µM -1.58281267057464 0.0862710017140634 no 3104 0.0567320839497073 4543 3107280
SGTC_1724 st037281 8.293 µM -1.5894872006392 0.0853752652164198 no 3105 0.0559752207298919 4487 574124 YDL195W SEC31
SGTC_344 k064-0035 6.43 µM -1.59459891910188 0.0846939858330542 no 3106 0.0554009772392727 4497 5088750
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.59530077444606 0.0846007632161175 no 3107 0.0553224962585231 4481 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2338 7999974 200 µM -1.60197393834352 0.0837182542847498 no 3108 0.05458068634547 4530 315925
SGTC_1703 st026983 48.3 µM -1.60258028159297 0.0836384109544087 no 3109 0.0545136750116764 4576 1104023
SGTC_668 1682-0499 62.6 µM -1.60279629466032 0.0836099801614028 no 3110 0.0544898175864708 4532 682214
SGTC_1777 st045864 34.765 µM -1.60494129455054 0.083328057633943 no 3111 0.0542533623315065 4566 4691462
SGTC_1154 4088-0362 150 µM -1.60933858483426 0.0827523461191074 no 3112 0.0537711632143863 4553 6618304
SGTC_3021 9087658 49.47 µM -1.61177321311104 0.0824348844951444 no 3113 0.0535056496115804 4572 25237042
SGTC_627 1391-0720 175 µM -1.6127922671475 0.0823022782233583 no 3114 0.0533948233482742 4532 997839
SGTC_1278 0874-0585 172 µM -1.61400239340493 0.0821450170489242 no 3115 0.053263453571526 4569 766306
SGTC_1887 st057648 70.8 µM -1.62163312769655 0.0811585797769466 no 3116 0.0524409625268793 4542 688672
SGTC_1738 st035555 74 µM -1.62230113231289 0.0810726530740738 no 3117 0.0523694431873611 4551 5331140
SGTC_103 0844-0104 51.839 µM -1.6223617720954 0.0810648562640988 no 3118 0.0523629546771593 4379 5375804
SGTC_1258 0671-0043 57.1 µM -1.62717201213464 0.0804481769159245 no 3119 0.0518502850751612 4554 4298767
SGTC_3302 9125395 16.351 µM -1.63058345548858 0.0800129779372773 no 3120 0.0514891212429239 4519 17599668
SGTC_2838 9002687 71.43 µM -1.63187973889339 0.079848078131366 no 3121 0.0513524115222414 4541 6457060
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.63298350970502 0.0797078705022995 no 3122 0.0512362324584318 4565 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1453 4237-0541 195 µM -1.63809318305582 0.0790612347460529 no 3123 0.0507011284130483 4566 739892
SGTC_833 3852-0053 558 µM -1.64136703392065 0.078649017790116 no 3124 0.0503606243656534 4608 3123681
SGTC_3245 9134821 49.47 µM -1.64520013475684 0.0781684569617372 no 3125 0.049964272878699 4566 17014901
SGTC_1642 st009582 77.7 µM -1.64700959772003 0.0779423775571688 no 3126 0.0497780365485269 4556 6739311
SGTC_40 0327-0103 19.753 µM -1.65349556969138 0.0771360775512911 no 3127 0.0491150235086862 4412 409036
SGTC_2594 a-mangostin 100 µM -1.65393987194618 0.0770810771885255 no 3128 0.0490698651490225 4569 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2030 5175110 200 µM -1.6634752974381 0.0759078539161002 no 3129 0.0481086658091252 4572 2831986
SGTC_2046 4110841 106 µM -1.66557395863938 0.0756514733458482 no 3130 0.0478991507600096 4585 44119630 YMR134W ERG29
SGTC_2154 5570129 200 µM -1.66817875621902 0.0753341793743457 no 3131 0.047640123366975 4628 673366
SGTC_2989 9073649 71.4286 µM -1.67009559754254 0.0751013349487561 no 3132 0.0474502255259218 4540 21367202
SGTC_2058 5236698 133 µM -1.67174391852211 0.0749015477083977 no 3133 0.0472874149015956 4547 766665
SGTC_3194 9111903 49.47 µM -1.67304401601329 0.0747442536275558 no 3134 0.0471593156538717 4561 17087251
SGTC_1475 4092-1048 11.7 µM -1.67692193211135 0.0742765756854783 no 3135 0.0467788743835642 4587 2881759
SGTC_821 1114-0266 29.2 µM -1.67903022098821 0.0740232548314842 no 3136 0.0465730770462805 4594 3123235
SGTC_3259 9138485 49.47 µM -1.68223837016783 0.0736390476934217 no 3137 0.0462613132300826 4547 17646153
SGTC_2848 9016370 25.97 µM -1.68442243684227 0.0733783579357004 no 3138 0.046050028834451 4555 7894410
SGTC_2094 5332512 191.667 µM -1.69172199946207 0.0725122041036868 no 3139 0.0453494959026386 4607 755774
SGTC_3034 9090421 49.47 µM -1.69496153526488 0.0721303245853415 no 3140 0.0450413589176365 4539 17173761
SGTC_1422 4031-0024 15.5 µM -1.69807684640587 0.0717645446834279 no 3141 0.0447466294564496 4534 782427
SGTC_503 tyrphostin 8 294 µM -1.69983260547017 0.0715590225038364 no 3142 0.0445812082998118 4595 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1713 st033146 12.748 µM -1.70026294486416 0.0715087176625001 no 3143 0.0445407385632993 4559 674619
SGTC_2472 5377652 49.4 µM -1.70180829419653 0.0713282965843407 no 3144 0.0443956555861972 4618 1610903
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.70220978885847 0.0712814789149343 no 3145 0.0443580242042398 4557 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2736 butenafine 14.65 µM -1.70771423577178 0.0706419902861673 no 3146 0.0438446896851405 4540 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2074 5212007 75.395 µM -1.71012882543261 0.0703628662962282 no 3147 0.0436210267480657 4536 758611
SGTC_876 0720-0963 56.8 µM -1.71450820379799 0.0698587796806822 no 3148 0.0432177158472493 4603 765861
SGTC_1494 4358-1428 177 µM -1.7167414318464 0.0696027971248954 no 3149 0.0430132131865877 4615 1564571
SGTC_1235 benzylparaben 21.5 µM -1.71863849316978 0.0693859153279363 no 3150 0.0428401089993596 4636 7180
SGTC_2462 5162487 171.77 µM -1.72437158837671 0.068733641401235 no 3151 0.0423203916042839 4574 2259986
SGTC_2954 9074818 52.69 µM -1.72688266223604 0.0684494412600066 no 3152 0.0420943693936339 4589 16648742
SGTC_1984 st072354 53.1 µM -1.73199415690808 0.0678737307440855 no 3153 0.0416373013975184 4505 5762938
SGTC_2443 5493264 126.67 µM -1.74762959090637 0.066135903911616 no 3154 0.0402640939810493 4623 5340055
SGTC_339 3091-4833 71.4 µM -1.74898769525079 0.0659865971377872 no 3155 0.0401465731961012 4428 3240077
SGTC_878 0828-0289 13.7 µM -1.75504326986016 0.0653240381766803 no 3156 0.0396259533813807 4587 745350 YLR208W SEC13
SGTC_3030 9087619 49.47 µM -1.75527951838919 0.0652982944829792 no 3157 0.0396057540389296 4604 25236973
SGTC_1482 3346-2049 8.48 µM -1.75762298574488 0.0650433559825192 no 3158 0.0394058398276295 4639 3826804
SGTC_657 3534-0529 86.7 µM -1.7578717178318 0.065016342605773 no 3159 0.0393846695127922 4639 1049549
SGTC_1740 st038286 13.222 µM -1.75865684243151 0.0649311318117675 no 3160 0.0393179059601808 4604 716786
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.75995417200653 0.0647905206269276 no 3161 0.0392077885747001 4633 6708784 An antioxidant flavonoid
SGTC_649 1123-0311 367 µM -1.760186485885 0.0647653662449175 no 3162 0.039188096286999 4503 693629 YIL048W NEO1
SGTC_181 1447-1644 8.07 µM -1.76052046460061 0.064729217129851 no 3163 0.0391598003970428 4577 534600
SGTC_1208 2323-2347 50.3 µM -1.76192825797456 0.0645770128987024 no 3164 0.0390407097682835 4622 5412760
SGTC_774 k060-0086 136 µM -1.76250044385566 0.0645152302736608 no 3165 0.0389923907279987 4607 5911235
SGTC_2062 5245942 200 µM -1.77041868077599 0.0636649539693455 no 3166 0.0383287100265999 4649 1376160
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.77277416826852 0.0634137068013226 no 3167 0.0381330677242852 4673 688664
SGTC_3339 9145883 14.936 µM -1.78668397422005 0.0619457266128397 no 3168 0.0369942903457206 4557 2030670
SGTC_739 1486-1183 203 µM -1.78796539869153 0.0618118359006616 no 3169 0.0368907952263233 4615 4346692
SGTC_3048 9093155 49.47 µM -1.78799794958859 0.061808437737192 no 3170 0.0368881693172203 4623 25236002
SGTC_2232 chlorophetanol 41.5365 µM -1.79194954059698 0.0613969922095297 no 3171 0.0365705246178841 4694 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2129 girgensonine 121.053 µM -1.79375012545111 0.0612102236280506 no 3172 0.0364265303756765 4601 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2823 7987624 58.44 µM -1.79441448428622 0.0611414241629169 no 3173 0.0363735183775801 4557 2239440
SGTC_2684 capsaicin 100 µM -1.79563782943707 0.0610148954838068 no 3174 0.0362760676915373 4644 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1194 1488-0194 225 µM -1.79958347435138 0.0606081979275025 no 3175 0.0359632162085646 4628 1391452
SGTC_2179 6298986 200 µM -1.80223099242758 0.0603364958380849 no 3176 0.0357545352450313 4587 738374
SGTC_554 4483-2211 187 µM -1.80238466190602 0.0603207547946911 no 3177 0.0357424533413558 4661 747107
SGTC_1294 1000-1494 117 µM -1.80616539816457 0.0599344886924358 no 3178 0.0354462540038727 4640 712797 YDL207W GLE1
SGTC_3013 9080133 71.4286 µM -1.82251485576134 0.0582863753156462 no 3179 0.0341884508556402 4654 17050193
SGTC_1658 st012944 20 µM -1.83101096393659 0.0574440917542787 no 3180 0.0335494533138931 4495 24207260
SGTC_1892 st058411 7.36 µM -1.83110347878306 0.0574349730411204 no 3181 0.0335425496979253 4622 3934738
SGTC_1438 4092-1045 4 µM -1.83430368271097 0.0571202458180109 no 3182 0.0333044639057284 4667 1351342
SGTC_1003 4049-0218 100 µM -1.83540394815157 0.0570123532737699 no 3183 0.0332229295834792 4638 295161
SGTC_2404 5161160 200 µM -1.83712953091219 0.0568434650422905 no 3184 0.0330953877908299 4599 2831543
SGTC_1405 3909-7894 12 µM -1.84056497074355 0.0565084009713768 no 3185 0.0328426675088085 4634 7104060
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.85561176934538 0.0550591635649947 no 3186 0.0317544574572491 4651 94937 An inhibitor of serotonin biosynthesis.
SGTC_326 k292-0812 17.5 µM -1.85596070928066 0.0550259070163179 no 3187 0.0317295793050055 4646 3579357
SGTC_2428 5615643 7.78 µM -1.8593256150018 0.0547060206169882 no 3188 0.0314904991700809 4646 2253075
SGTC_1302 1159-0335 255 µM -1.8683014314847 0.0538599192407713 no 3189 0.0308600336113771 4675 649284
SGTC_1812 st052057 4.327 µM -1.8704743816993 0.0536566529497521 no 3190 0.0307089856435628 4671 3645418
SGTC_1500 4488-1866 171 µM -1.87390547560996 0.0533369327253499 no 3191 0.0304717273142046 4680 2900003
SGTC_943 3253-1379 105 µM -1.87786712734191 0.0529696536656628 no 3192 0.0301996721848178 4614 668464
SGTC_1827 berberine 7.24 µM -1.87945214957983 0.0528232714976858 no 3193 0.0300913906727121 4582 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.88308944359982 0.0524885682637622 no 3194 0.0298441237913837 4644 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_507 nimesulide 162 µM -1.88420266064988 0.0523864673475482 no 3195 0.0297687839031085 4660 4495 A COX2 inhibitor.
SGTC_113 0099-0221 2.5 µM -1.88611124847586 0.0522117844011398 no 3196 0.0296399824143617 4615 89219
SGTC_661 1304-0007 33.6 µM -1.89023000740188 0.0518363925920488 no 3197 0.029363602537376 4687 3117130
SGTC_1764 st044502 93.5 µM -1.89547698020606 0.051361283521537 no 3198 0.0290146193191572 4659 8407
SGTC_1340 1486-1359 257 µM -1.89932812142612 0.0510147750726106 no 3199 0.0287606738240416 4633 4309068
SGTC_134 0269-0018 6.916 µM -1.90074570554847 0.050887696684382 no 3200 0.0286676643900806 4613 4378915
SGTC_798 1287-0182 476 µM -1.90190178696651 0.0507842472106984 no 3201 0.0285919977712996 4689 1649755
SGTC_892 0929-0076 29 µM -1.90383168068246 0.0506119279674693 no 3202 0.0284660545499595 4661 5751038
SGTC_2521 angolensin 13.4 µM -1.90895456285131 0.0501567668218344 no 3203 0.0281339766886887 4680 821428 A flavenoid.
SGTC_2871 9038510 12.99 µM -1.91026405412192 0.0500409455113048 no 3204 0.0280496117583371 4616 4945164
SGTC_1300 1094-0077 113 µM -1.91501538112701 0.049622491898908 no 3205 0.0277452710423891 4654 5532636
SGTC_999 SEC7.066 22.7 µM -1.93014801510595 0.048308330000825 no 3206 0.0267942502920463 4647 740511 YDR170C SEC7
SGTC_753 1322-0200 289 µM -1.93709666903748 0.0477142885340117 no 3207 0.0263667638655635 4709 5403907
SGTC_1908 st060353 56.5 µM -1.94007655645606 0.0474613363162489 no 3208 0.0261851933199072 4649 4227716
SGTC_2877 9040724 71.43 µM -1.9439536612759 0.0471338320260923 no 3209 0.0259505196677594 4631 6463895
SGTC_522 1273-0010 11.6 µM -1.9460926734745 0.0469539237382708 no 3210 0.0258218042570756 4669 5705015
SGTC_3093 9117344 49.47 µM -1.95304049023083 0.0463733526186208 no 3211 0.0254073987728288 4690 24824913
SGTC_814 3342-0569 96 µM -1.9533443220075 0.0463480960452033 no 3212 0.0253894044668742 4699 4346283
SGTC_3147 9097027 49.47 µM -1.95523983907274 0.0461907769862452 no 3213 0.0252773841720385 4676 25236841
SGTC_663 1486-0733 13.9 µM -1.95530567787018 0.0461853203895747 no 3214 0.0252735007179812 4684 722445 YPR165W RHO1
SGTC_1573 oleylamine 1.06 µM -1.95683229455163 0.0460589423496138 no 3215 0.0251835944151545 4656 5356789 An amine of the fatty acid oleic acid.
SGTC_1250 0485-0349 40.2 µM -1.96555455720452 0.0453422049856589 no 3216 0.0246750438633498 4643 6842794 YDL195W SEC31
SGTC_1678 st019265 80.2 µM -1.9783209919957 0.0443093487266323 no 3217 0.0239462532161915 4649 5367020
SGTC_1974 st069448 26.9 µM -1.98006416244943 0.0441698022318193 no 3218 0.0238481597224828 4673 6323587 YNR016C ACC1
SGTC_2918 7977171 22.06 µM -1.99048952625297 0.0433425975128493 no 3219 0.0232685183112191 4670 2236483
SGTC_1780 st038448 24.544 µM -1.99066307309851 0.0433289339469823 no 3220 0.0232589704990679 4683 728868 YDL195W SEC31
SGTC_495 decylubiquinone 155 µM -1.99590221215546 0.0429180845537405 no 3221 0.0229722839423161 4686 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3210 9128157 49.47 µM -1.99729802578598 0.0428091585913227 no 3222 0.0228964088501868 4615 17590849
SGTC_2614 arthonioic acid 13.39 µM -1.99954625231107 0.0426341822505085 no 3223 0.0227746413430162 4566 6710684
SGTC_3142 9086498 49.47 µM -2.00551229448592 0.0421726555008905 no 3224 0.022454153860385 4567 25236367
SGTC_1796 st049173 110.4 µM -2.01021957712033 0.0418113656339928 no 3225 0.0222039771417258 4678 94134
SGTC_2674 ligustilide 100 µM -2.02068073609076 0.0410174305308044 no 3226 0.0216564126248067 4722 5319022 A signalling regulator.
SGTC_3054 9094397 49.47 µM -2.02224572443071 0.0408997162121845 no 3227 0.0215754863430478 4658 2598354
SGTC_1546 5-methoxyflavanone 78.7 µM -2.0273196045055 0.0405199556312182 no 3228 0.021314868931103 4714 147795
SGTC_3007 9078383 71.4286 µM -2.03340757783806 0.0400680772937 no 3229 0.0210056811952757 4688 6496995
SGTC_2441 5730946 39.09 µM -2.04167520302195 0.039460979724177 no 3230 0.0205918800346062 4696 1774275
SGTC_3125 9127534 49.47 µM -2.04186817405686 0.0394468995887961 no 3231 0.0205823047452256 4641 1639235
SGTC_1187 1391-0724 117 µM -2.05019018159022 0.0388435623838428 no 3232 0.020172937870721 4725 6997986
SGTC_1616 st002734 56.1 µM -2.05445460141829 0.0385373210116695 no 3233 0.0199658565186958 4692 4026101
SGTC_2047 4141938 200 µM -2.06524600318797 0.037771139453096 no 3234 0.0194498648950538 4715 3807862
SGTC_100 0086-0128 49.5915 µM -2.06813849408071 0.0375679011508069 no 3235 0.0193135009344081 4683 93297
SGTC_2433 5607874 27.82 µM -2.08107560380587 0.0366697874659397 no 3236 0.0187134932351968 4676 2252428
SGTC_2144 5628481 200 µM -2.09511777588798 0.0357149147214932 no 3237 0.0180802620655753 4703 2818399
SGTC_723 4182-0001 115 µM -2.09565329215825 0.0356789066611782 no 3238 0.0180564790305613 4692 744821 YLR208W SEC13
SGTC_2864 9034755 47.6 µM -2.09734923209756 0.0355650681080545 no 3239 0.0179813358396674 4672 4930451
SGTC_3075 9116269 49.47 µM -2.10381881353829 0.0351335342501956 no 3240 0.0176971275190263 4690 17015205 YNL244C SUI1
SGTC_3225 9130819 49.47 µM -2.10728862186821 0.0349038669284343 no 3241 0.0175462845138478 4680 4547121
SGTC_2658 polymyxin b sulfate 77.05 µM -2.11390504755437 0.0344693400870022 no 3242 0.0172616890219593 4733 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2681 menadione 3.18 µM -2.12220307225587 0.0339306685466443 no 3243 0.0169103443384079 4722 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2258 7960471 200 µM -2.12779030436923 0.033571885080144 no 3244 0.0166772368033906 4726 2974708
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.1292341329294 0.0334796792589186 no 3245 0.0166174471140071 4683 6728940
SGTC_2064 5220758 200 µM -2.13166256582978 0.033325064891622 no 3246 0.0165172981534697 4712 788518
SGTC_1850 st056238 17 µM -2.13599008170597 0.0330509967648961 no 3247 0.0163401111298932 4718 5393177
SGTC_2213 7173844 200 µM -2.14210258555734 0.0326670494531292 no 3248 0.0160926139498389 4733 892728
SGTC_2783 7738165 71.43 µM -2.14235186601188 0.0326514696817233 no 3249 0.0160825890566491 4694 17201110
SGTC_1047 2043-3044 82 µM -2.14260123219013 0.0326358906839176 no 3250 0.0160725660711433 4682 669592
SGTC_1916 st067606 49.2 µM -2.1431701733041 0.0326003693867931 no 3251 0.0160497181785301 4621 19590279
SGTC_2889 9059656 51.95 µM -2.14973127683535 0.0321930325804891 no 3252 0.0157882384740845 4732 3949838
SGTC_989 1501-0895 10.3 µM -2.15470530333811 0.0318870347419876 no 3253 0.0155924512693177 4710 2830112
SGTC_775 4577-0580 57.3 µM -2.15862836355625 0.0316473895188496 no 3254 0.015439505227847 4708 2006902
SGTC_395 anisomycin 6.25 µM -2.15923395812283 0.0316105289379347 no 3255 0.0154160103983806 4718 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1620 st003704 16.5 µM -2.1684527940766 0.031053776088224 no 3256 0.0150621262893143 4714 2834414
SGTC_2193 5925765 200 µM -2.16942386533959 0.0309956054766077 no 3257 0.0150252593671676 4729 877370
SGTC_1737 st035557 69.7 µM -2.17262310037684 0.0308045975140622 no 3258 0.0149043479028175 4608 5716916
SGTC_2198 6589944 200 µM -2.19160346010499 0.0296913295594689 no 3259 0.0142040759453969 4736 5290268
SGTC_1715 st032160 10.2275 µM -2.19528646520606 0.0294792223965206 no 3260 0.014071527590666 4649 5289825
SGTC_2709 st078560 56 µM -2.19646673746933 0.0294115163188864 no 3261 0.0140292767146832 4698 17250903
SGTC_950 1165-0508 94.1 µM -2.20395457071165 0.0289849799446986 no 3262 0.0137637695764099 4706 6148369
SGTC_167 3672-0051 66.205 µM -2.21302860906926 0.0284749892941098 no 3263 0.0134478366586939 4674 3237971
SGTC_1111 tnp00062 510.699 nM -2.21765850019429 0.0282176641850297 no 3264 0.0132890629367449 4696 676306
SGTC_903 1134-0042 114 µM -2.2212267780513 0.0280206659692762 no 3265 0.0131678026820786 4736 701009
SGTC_517 1365-0151 113 µM -2.2234027752453 0.0279010962251112 no 3266 0.0130943263693076 4703 768657
SGTC_702 1488-0190 94 µM -2.25566421039766 0.0261776545375049 no 3267 0.0120458342911805 4747 949357
SGTC_3199 9111318 49.47 µM -2.25892061629266 0.0260087494621706 no 3268 0.011944161661725 4656 8548020
SGTC_2854 9024559 71.43 µM -2.26474358595534 0.0257089929477475 no 3269 0.0117642095594993 4709 3163529
SGTC_23 0213-0011 39.996 µM -2.27680524900995 0.0250972718184155 no 3270 0.011398928971122 4733 627608
SGTC_2920 7982904 15.77 µM -2.28208709043282 0.0248332638223287 no 3271 0.0112420995078141 4717 6456808
SGTC_1820 st053765 18.6 µM -2.28329100641266 0.0247734142567582 no 3272 0.0112066162166431 4750 3690829
SGTC_2689 tacrolimus 100 µM -2.28478432562525 0.0246993459167912 no 3273 0.0111627385960091 4712 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_998 3996-0085 177 µM -2.29288920715547 0.0243005785829485 no 3274 0.0109271921742466 4730 715391
SGTC_2185 6113692 200 µM -2.30611999333428 0.0236612334101279 no 3275 0.0105519642210276 4725 874150
SGTC_1786 berberine 21.6 µM -2.34245178993546 0.0219779415378563 no 3276 0.00957875441474275 4666 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1992 st073643 23.3 µM -2.34529502674159 0.0218505875915062 no 3277 0.00950601451175205 4747 3161292
SGTC_2621 lithochol-11-enic acid 100 µM -2.35233964944435 0.0215377282539365 no 3278 0.00932786569850206 4705 6708711
SGTC_1763 st044482 94.5 µM -2.35691884273816 0.0213363983614148 no 3279 0.00921363682263223 4743 88505
SGTC_1510 1123-0200 71.5 µM -2.36457046843284 0.0210035367069447 no 3280 0.00902549644539214 4739 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1160 4092-0570 10.5 µM -2.38133907805664 0.0202894106570668 no 3281 0.00862491284431107 4748 4994975
SGTC_2414 st077232 92.9 µM -2.39787127746058 0.0196056100876318 no 3282 0.0082453296133919 4711 729801
SGTC_404 fumagillin 50 µM -2.40082081184452 0.0194856925732571 no 3283 0.00817917232455186 4746 12015870 A methionine aminopeptidase binder.
SGTC_2728 chlorpromazine 9.18 µM -2.40672535651678 0.0192475061315167 no 3284 0.00804813482944706 4787 2726 A thorazine and dopamine antagonist.
SGTC_9 0092-0002 10.449 µM -2.41772616020307 0.0188103360726896 no 3285 0.0078089126307065 4753 759368
SGTC_1847 st056231 15 µM -2.42485154353179 0.0185317063319068 no 3286 0.00765732396505266 4747 5393180
SGTC_1491 4138-0063 26.5 µM -2.44629199456692 0.0177144071987259 no 3287 0.00721670271603527 4786 23883227
SGTC_3249 9135183 49.47 µM -2.44964982823522 0.0175892356264818 no 3288 0.00714976019714312 4732 4902779
SGTC_3177 9107506 49.47 µM -2.46642771846381 0.0169750495641944 no 3289 0.00682341342385358 4763 8897194
SGTC_2291 7917025 104.35 µM -2.47012277702381 0.0168422765132419 no 3290 0.0067533343173974 4707 2964612
SGTC_2777 climbazole 1.536 µM -2.47327804945882 0.0167296033777425 no 3291 0.00669399677245221 4578 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2964 9083345 53.42 µM -2.47358765429148 0.0167185823721293 no 3292 0.00668819929325545 4731 17741579
SGTC_3254 9136651 49.47 µM -2.52132926808624 0.0150918055024569 no 3293 0.00584561976107076 4741 16454030
SGTC_1200 1643-0193 18.4 µM -2.53583356426045 0.0146253352676659 no 3294 0.00560900178427068 4772 5403974
SGTC_936 3005-4620 401 µM -2.53810017214234 0.0145535717472627 no 3295 0.00557280385723417 4760 777207
SGTC_1444 4112-3581 28 µM -2.54201541551937 0.0144303242213472 no 3296 0.00551076562011036 4795 2877249
SGTC_1588 farnesol 29.9 µM -2.57675666092707 0.013375522163644 no 3297 0.00498660665534383 4778 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2565 isoliquiritigenin 100 µM -2.59381232043913 0.012882517174405 no 3298 0.00474591425533174 4730 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2818 7996756 12.99 µM -2.60284067776684 0.0126279659113778 no 3299 0.00462274537568643 4764 2241621
SGTC_1547 harmine 94.2 µM -2.6213312953235 0.0121201884555552 no 3300 0.00437935502382382 4710 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2991 9074669 71.4286 µM -2.62323133613364 0.0120690276339422 no 3301 0.00435500547439835 4716 17333109
SGTC_2785 7756463 72.73 µM -2.62368548742748 0.0120568268403958 no 3302 0.00434920334558467 4749 2201551
SGTC_431 k089-0097 107 µM -2.65126338523058 0.0113357101705069 no 3303 0.00400956395908992 4542 5499420
SGTC_1883 5-benzylidenerhodanine 20 µM -2.65381143460602 0.0112710144007187 no 3304 0.00397941443498584 4771 1273210
SGTC_551 k048-0028 34.9 µM -2.65438500657985 0.011256495560921 no 3305 0.00397265576383551 4746 6836383
SGTC_2857 9024691 58.44 µM -2.67496907765411 0.0107461000437497 no 3306 0.00373680715769305 4748 16478292
SGTC_1366 1683-0113 21.9 µM -2.68066135129712 0.0106085622824869 no 3307 0.00367384161286138 4785 708623
SGTC_1104 tacrolimus 29.8 µM -2.68262356227949 0.0105615076681792 no 3308 0.00365235808499616 4796 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1531 st059297 52.4 µM -2.68701439102549 0.0104568720208966 no 3309 0.00360469232816806 4783 7566702
SGTC_29 0299-0004 12.984 µM -2.69800044169548 0.0101990181818639 no 3310 0.0034878674054043 4748 16871 A napthoquinone isolated from Swertia calycina.
SGTC_403 arphamenine a 50 µM -2.72449099518769 0.00959995064701689 no 3311 0.00322003432488886 4787 5487158 An arginine aminopeptidase inhibitor.
SGTC_1005 4092-0690 4.4 µM -2.73544446983145 0.00936137644433884 no 3312 0.00311480481029304 4775 1529343
SGTC_2666 tannic acid 100 µM -2.75181518531389 0.00901448114085379 no 3313 0.00296329787275903 4773 16134267 A thiamine antagonist.
SGTC_133 0724-0033 378.92 µM -2.77148103230923 0.00861269032453351 no 3314 0.00279009616358798 4755 280309
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.78872430600956 0.00827340900530981 no 3315 0.00264580448189167 4753 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1101 ebselen 5.29 µM -2.81309283769096 0.00781396282185831 no 3316 0.00245337412582572 4793 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1236 0330-0013 258 µM -2.83013028257546 0.00750621739313528 no 3317 0.00232645264873266 4792 4617066
SGTC_2887 9044784 58.44 µM -2.8611588114607 0.00697308974053531 no 3318 0.00211047777716063 4745 6465546
SGTC_2516 gossypol 71.55 µM -2.87933977716018 0.00667648678054351 no 3319 0.00199254366056721 4783 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1383 3049-0032 20.7 µM -2.89432251055939 0.00644049840355161 no 3320 0.00189988830596726 4783 712864
SGTC_3168 9103419 49.47 µM -2.90024350872987 0.00634929250568848 no 3321 0.00186436431846715 4795 16649256
SGTC_2318 6029776 164 µM -2.90555328530861 0.00626847597545322 no 3322 0.00183302211078457 4776 818325
SGTC_1572 epiandrosterone 68.9 µM -2.91176687967007 0.00617506067786178 no 3323 0.00179695373227055 4784 441302 A steroid.
SGTC_374 0880-0231 82.3 µM -2.92546307342406 0.00597349448752357 no 3324 0.00171971996327815 4724 6833587
SGTC_1775 st081588 35.1725 µM -2.95945118988724 0.0054982801139266 no 3325 0.00154093759204595 4778 1426443 YGL099W LSG1
SGTC_985 1493-0307 8.71 µM -2.96702648804628 0.00539705762934454 no 3326 0.00150347526360864 4793 3278274
SGTC_3126 9127922 49.47 µM -2.99417538533966 0.00504776154330466 no 3327 0.00137593854561714 4752 45595682
SGTC_3049 9092223 49.47 µM -3.00210885683829 0.0049495637521365 no 3328 0.00134058140693359 4776 8623917
SGTC_2634 4'-methoxyflavone 100 µM -3.00978522986415 0.00485617203826977 no 3329 0.00130716239909056 4772 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1112 tnp00069 1.16933 µM -3.01108322415526 0.00484053666710258 no 3330 0.00130158746544993 4777 145826
SGTC_1982 st072467 71.9 µM -3.03543265952694 0.00455542867952251 no 3331 0.00120095426842284 4792 3163533
SGTC_2416 tofa 880 nM -3.05451604624229 0.00434256163201162 no 3332 0.00112711977568937 4774 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1988 st071872 53.4 µM -3.05918424914551 0.00429186244251079 no 3333 0.00110970303085879 4798 16414116
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -3.08011373112753 0.00407100219900306 no 3334 0.00103460781954912 4793 2374 Ca(2+)-ATPase inhibitor.
SGTC_1492 4158-0558 28.5 µM -3.10570412191553 0.00381481465496984 no 3335 0.000949132765340684 4804 3967268
SGTC_1578 josamycin 24.2 µM -3.12025351977122 0.00367569246312743 no 3336 0.000903477249177804 4796 5282165 A P450 substrate.
SGTC_310 1273-0058 1.06 µM -3.16920385503514 0.00324042531315634 no 3337 0.000764285713957581 4529 2734232
SGTC_1350 1495-0454 146 µM -3.19971448179706 0.00299315702029743 no 3338 0.000687818949544113 4798 1069057
SGTC_3179 9107801 49.47 µM -3.27676870830094 0.0024426082815111 no 3339 0.000525011729122478 4798 4818259
SGTC_1113 artemisinin 1.17947 µM -3.32911096833262 0.00212272487224037 no 3340 0.000435618421445728 4804 2240 An anti-malaria and mitochondrial poison.
SGTC_1100 amiodarone 5.07 µM -3.36787016924123 0.00191087917340735 no 3341 0.000378756296210142 4806 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1822 st052468 42 µM -3.46369795540661 0.00146703515617171 no 3342 0.000266402202422527 4803 2873678
SGTC_1923 st058458 19.1 µM -3.46371015722231 0.00146698519898804 no 3343 0.000266390119674898 4799 3534982
SGTC_444 curcumin 90.4 µM -3.46538901864171 0.00146012631815577 no 3344 0.000264732501145491 4766 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2215 7188065 200 µM -3.46985808432275 0.00144201064655591 no 3345 0.000260366712972105 4788 940217
SGTC_1203 3992-3522 103 µM -3.47419525420226 0.00142462603181597 no 3346 0.000256194014890972 4783 5322312
SGTC_2683 piperine 63.03 µM -3.53804039540267 0.0011899134749488 no 3347 0.000201554191438431 4808 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_568 1193-0097 7.48 µM -3.58903127077023 0.00102849916158094 no 3348 0.000165954515285546 4727 3646150
SGTC_1856 st057054 55.7 µM -3.69829628125618 0.000748063878176102 yes 3349 0.000108525725069728 4804 1266018
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -3.71821132498224 0.000705270048554796 yes 3350 0.000100319198768565 4796 6708514
SGTC_1824 st053723 68.6 µM -3.79588389311221 0.000559044988411356 yes 3351 7.35591723338104e-05 4808 675225
SGTC_2678 equilin 100 µM -3.8875177023562 0.000422752111283613 yes 3352 5.06373019158795e-05 4808 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1849 st056239 19.2 µM -3.94578970577156 0.000352861311663429 yes 3353 3.97686994793972e-05 4796 5393181
SGTC_696 1560-0013 611 µM -4.14760145088246 0.0001853252922109 yes 3354 1.67988302821372e-05 4810 1650269
SGTC_2616 abietic acid 100 µM -4.57440823186763 4.32583847047881e-05 yes 3355 2.38783934730985e-06 4807 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1979 st071809 45.3 µM -6.90278877623647 1.61722188561288e-09 yes 3356 2.54957113324372e-12 4809 4976333