SGTCid condition conc unit EAF1|YDR359C.score EAF1|YDR359C.strain.pval EAF1|YDR359C.strain.significant EAF1|YDR359C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_108 0509-0257 621.132 µM 7.96683572514319 5.02535710241351e-15 yes 1 8.13944157866283e-16 5 536624
SGTC_221 trifluoperazine 10.304 µM 6.52293766641406 1.30404434754946e-10 yes 2 3.44717601744391e-11 108 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2489 cantharidin 73.42 µM 5.95990275161015 4.02411365730682e-09 yes 3 1.26194042673704e-09 12 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_863 0466-0191 129 µM 5.68627931337513 1.91303020368847e-08 yes 4 6.49184891894613e-09 32 765160 YPR165W RHO1
SGTC_2415 st077333 57.7 µM 5.51205529688174 4.9765340933068e-08 yes 5 1.77333723208766e-08 14 2766255
SGTC_150 3970-0969 77.2 µM 5.2977352810448 1.55152675235481e-07 yes 6 5.86238889563435e-08 31 6615640
SGTC_667 1498-1044 59 µM 5.28633832402427 1.64625705785474e-07 yes 7 6.23945027912346e-08 3 6739982
SGTC_916 4466-0038 42 nM 5.28351714053388 1.67055488219262e-07 yes 8 6.33635003972054e-08 33 5722064 YGL116W CDC20
SGTC_2414 st077232 92.9 µM 5.09006858216136 4.48210039562779e-07 yes 9 1.78967017204426e-07 8 729801
SGTC_268 camptothecin 39.6153 µM 5.08106710935367 4.68874756472234e-07 yes 10 1.8766024245466e-07 45 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3158 9100007 49.47 µM 5.04954374073114 5.48720725598124e-07 yes 11 2.21433264219235e-07 8 19297233
SGTC_46 0329-0187a 2.197 µM 4.7182278276665 2.70922200587616e-06 yes 12 1.18953990518757e-06 47 46494817
SGTC_115 0527-0192 112.043 µM 4.58120577572168 5.08992520813797e-06 yes 13 2.31151337231615e-06 46 4233931
SGTC_2416 tofa 880 nM 4.56258439697098 5.53792298409856e-06 yes 14 2.52638860125494e-06 36 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_445 e6 berbamine 66 µM 4.47730122045175 8.11617364939654e-06 yes 15 3.77962784162043e-06 82 6610268 A calcium/calmodulin antagonist.
SGTC_1627 st003713 25.6 µM 4.46958659077261 8.39892727003416e-06 yes 16 3.9185463465685e-06 55 16195070 YER133W GLC7
SGTC_1750 st081859 2.357 µM 4.41320133789659 1.07696003689546e-05 yes 17 5.09265965656018e-06 156 5291695
SGTC_2771 fluoxetine 41.05 µM 4.27629289632268 1.94566898702524e-05 yes 18 9.50155871158278e-06 12 3386 A selective serotonin reuptake inhibitor.
SGTC_855 0428-0020 25 µM 4.19085479310241 2.78975721015221e-05 yes 19 1.38952740126053e-05 21 6812414
SGTC_3014 9081533 49.47 µM 4.18880072782154 2.81379805282517e-05 yes 20 1.40216254862803e-05 8 21367265
SGTC_3153 9100258 49.47 µM 4.08330451999812 4.34930801549041e-05 yes 21 2.21998896880245e-05 17 25236848
SGTC_871 0574-0004 149 µM 4.07485482426319 4.50169594440731e-05 yes 22 2.30215306349143e-05 44 9551173
SGTC_2077 5212015 200 µM 4.01173425683112 5.81031148115881e-05 yes 23 3.01371633808526e-05 68 780900
SGTC_1972 st070201 17.4 µM 3.9489293390409 7.46265893080378e-05 yes 24 3.92507589569873e-05 24 2829099
SGTC_3052 9092717 49.47 µM 3.91109665064279 8.66187498666388e-05 yes 25 4.59389967907792e-05 29 25237534
SGTC_2646 retinol 96.75 µM 3.90947469886808 8.71713508077673e-05 yes 26 4.62485211472858e-05 10 445354 A vitamin A analog and teratogen.
SGTC_654 1124-0271 80.9 µM 3.83127624576021 0.000118111089489954 yes 27 6.37401382080984e-05 24 5403748
SGTC_1856 st057054 55.7 µM 3.76741756299191 0.000150736110708042 yes 28 8.24724911153182e-05 31 1266018
SGTC_928 2764-0428 58.7 µM 3.75960992627011 0.000155259241583608 yes 29 8.50892451987833e-05 65 662578
SGTC_1088 bifonazole 369 nM 3.69099137872224 0.000200847690510113 yes 30 0.000111690854851089 21 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1631 benzylvanillin 81.9 µM 3.65086901449126 0.000233013271287992 yes 31 0.000130677255803321 35 75506
SGTC_53 0973-0023 39.979 µM 3.5815038758714 0.000300202818131276 yes 32 0.000170811034473572 20 674768
SGTC_3009 9080819 71.4286 µM 3.53557334134015 0.000354184840203803 yes 33 0.000203445640063813 25 17027216
SGTC_1135 dihydrocapsaicin 536.708 nM 3.52579185829006 0.000366789203275409 yes 34 0.000211109331337849 50 107982 A Capsaicinoid.
SGTC_213 1246-0773 967 nM 3.52369303279688 0.000369547472171016 yes 35 0.000212788488684405 33 6251622
SGTC_608 k048-0125 159 µM 3.51888312448744 0.000375941462122599 yes 36 0.000216683789429709 47 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_799 1310-0557 151 µM 3.48936951800692 0.000417478367469355 yes 37 0.000242080681438531 41 5354492
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 3.4860850203417 0.000422355246636343 yes 38 0.000245072599681392 56 368090
SGTC_3166 9102297 49.47 µM 3.40597066253736 0.000558977080113153 yes 39 0.000329646317293349 45 25237072
SGTC_1221 2958-7315 257 µM 3.36464931132097 0.000644447328031619 yes 40 0.000383205017263073 30 4562705
SGTC_961 1252-1571 372 µM 3.34530935780435 0.00068846051611602 yes 41 0.000410954202855485 50 6813498
SGTC_2521 angolensin 13.4 µM 3.33434213077235 0.000714634922999478 yes 42 0.000427507099319658 23 821428 A flavenoid.
SGTC_70 0141-0289 43.283 µM 3.30629239048414 0.000785807664756513 yes 43 0.000472696897606239 234 352408
SGTC_1373 2887-0003 58.5 µM 3.30460732322485 0.00079028444735355 yes 44 0.00047554776706652 41 776948
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 3.29059648257415 0.000828426986449896 yes 45 0.000499876053274568 96 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_56 0957-0365 83.25 µM 3.26255314674165 0.000909906603760567 yes 46 0.000552067336986371 75 6752360
SGTC_3274 9138298 49.47 µM 3.26035713093735 0.0009165882845133 yes 47 0.000556360048515609 43 17015756
SGTC_168 3970-0862 530.542 µM 3.24744400228899 0.000956798732356213 yes 48 0.000582232879707194 186 3135186
SGTC_1884 5633444 25 µM 3.2408283103841 0.000978021206532671 yes 49 0.000595914711453645 87 5724239
SGTC_43 0570-0105 72.5 µM 3.20458431318673 0.00110215393534916 no 50 0.000676288344344331 161 1114046 YDL195W SEC31
SGTC_2248 tofa 1.1 µM 3.20432894673415 0.00110307760895981 no 51 0.00067688853370517 63 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1611 st001856 99.4 µM 3.19755592721516 0.00112783641471603 no 52 0.000692987662820486 50 647478
SGTC_1151 3909-8316 15.3 µM 3.1817685330894 0.00118753620313055 no 53 0.000731893769604574 49 800431
SGTC_1623 st003709 20.3 µM 3.17914882869933 0.00119771794622781 no 54 0.000738541145170779 117 16192618
SGTC_1039 k821-0043 94 µM 3.1517697179916 0.0013090145466943 no 55 0.00081142102379741 57 15992768
SGTC_2455 5377712 9.75 µM 3.13400518242093 0.00138620280004291 no 56 0.000862189052458806 50 2243908
SGTC_2569 tetrandrine 100 µM 3.11115969418956 0.0014915755355084 no 57 0.000931770650113811 63 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_548 1436-0017 110 µM 3.06461605471503 0.00172918637179829 no 58 0.00108974797839193 78 9677137
SGTC_595 3909-8003 73.7 µM 3.05975642181631 0.00175588493122953 no 59 0.0011075853468733 45 699517
SGTC_842 0271-0008 11.1 µM 3.05684400083241 0.00177206483119411 no 60 0.00111840326986881 48 1221709
SGTC_2001 4023502 57.655 µM 3.04134685615444 0.0018604625578482 no 61 0.00117761170965011 67 108941 YCR052W RSC6
SGTC_11 0438-0307 1.3 µM 3.00860735239893 0.0020605259008107 no 62 0.00131224031088322 40 4011476
SGTC_1214 0358-0031 63.7 µM 2.99844659594193 0.00212647307945212 no 63 0.00135679854660938 53 4301366
SGTC_79 0052-0007 94.094 µM 2.96485917117958 0.00235831572519533 no 64 0.00151410759800759 80 2801472
SGTC_1427 4048-4900 550 nM 2.96335654309704 0.00236920341780555 no 65 0.00152151933937444 64 24132586
SGTC_2379 9035213 200 µM 2.94847669582606 0.0024795010064554 no 66 0.00159672107867665 62 646551
SGTC_3164 9100705 49.47 µM 2.94557482230367 0.00250154483124862 no 67 0.00161177585945582 29 17174235
SGTC_3178 9107506 49.47 µM 2.94347616635535 0.00251759734070457 no 68 0.00162274405833993 55 8897194
SGTC_18 0111-0177 500 nM 2.9392714533037 0.00255003948767761 no 69 0.00164492400304926 136 721752
SGTC_568 1193-0097 7.48 µM 2.93788431243389 0.00256082480248139 no 70 0.00165230155649064 229 3646150
SGTC_3154 9100113 49.47 µM 2.93482849343357 0.00258473003281946 no 71 0.00166866046956272 77 25237525
SGTC_2773 thioridazine 9.09 µM 2.93333899305514 0.0025964551232687 no 72 0.00167668765925144 50 5452 An antipsychotic.
SGTC_86 0417-1630 471.922 µM 2.91742098711995 0.00272479360041568 no 73 0.0017646952800196 238 3634867
SGTC_214 4373-3496 70 µM 2.90428372850464 0.00283499561962319 no 74 0.00184047207586924 140 3779166
SGTC_120 rhodamine 6G 52.259 µM 2.90086177512753 0.00286435306186362 no 75 0.00186068996129098 104 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1467 k284-1082 293 µM 2.89185555610023 0.00294293351459433 no 76 0.00191486987799891 65 3334705
SGTC_37 0566-0070 1.56 µM 2.88342531135947 0.00301824364078599 no 77 0.00196687959896652 92 1626686
SGTC_2864 9034755 47.6 µM 2.8819751214471 0.00303137228630157 no 78 0.00197595467391954 55 4930451
SGTC_232 clozapine 119 µM 2.84507392887741 0.0033832278400772 no 79 0.00222005582562644 127 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_20 0481-0013 4.944 µM 2.84446385819538 0.00338934131947029 no 80 0.00222431161972006 83 182045
SGTC_235 0330-0087 5 mM 2.836422571415 0.00347085552996263 no 81 0.00228110195049667 89 46494818 YHR062C RPP1
SGTC_2936 9038235 15.59 µM 2.82745039531523 0.00356388108198474 no 82 0.00234601420405271 96 4749415
SGTC_1848 st056003 16.4 µM 2.81285960108732 0.00371994886987137 no 83 0.00245515427520489 71 146492
SGTC_625 k213-0058 121 µM 2.79203774078692 0.00395328406221724 no 84 0.00261886232930676 236 3655420
SGTC_2055 5235184 200 µM 2.78952493108676 0.00398231195898524 no 85 0.00263927161194811 94 2836034
SGTC_795 0685-0265 78 µM 2.77451194208352 0.00415975266917318 no 86 0.0027642302150018 89 302754
SGTC_2513 baicalein 25.65 µM 2.76311104384225 0.00429919215670641 no 87 0.00286266423270382 80 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2961 9083290 32.55 µM 2.75791737509515 0.00436408778899395 no 88 0.00290854496124587 72 17741490
SGTC_1049 3226-0134 66 µM 2.75465752125522 0.00440526593470942 no 89 0.00293768000721345 112 5702385
SGTC_2658 polymyxin b sulfate 77.05 µM 2.75181372511333 0.00444147161768837 no 90 0.00296331108507137 111 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_944 3370-0224 231 µM 2.74203648409357 0.00456798662143573 no 91 0.00305297795807317 101 4580514
SGTC_3200 9114385 49.47 µM 2.73552753736424 0.00465398472369925 no 92 0.00311401875366581 110 17018030 YLR208W SEC13
SGTC_328 k915-0120 63.5 µM 2.73027678523912 0.00472440881831267 no 93 0.00316405853888914 77 6624543
SGTC_2134 5324836 1.464 µM 2.72168948370773 0.00484163334375655 no 94 0.00324745693071493 68 699272
SGTC_1395 3486-0190 4.35 µM 2.71931796684111 0.00487446033902658 no 95 0.00327083451822611 84 6748079
SGTC_1908 st060353 56.5 µM 2.70808319843407 0.00503268527756921 no 96 0.00338365276423286 118 4227716
SGTC_1783 st039459 87.517 µM 2.70529880246852 0.00507259982768289 no 97 0.00341214870548017 99 729761
SGTC_1167 k781-0610 148 µM 2.69300921064278 0.0052521596844112 no 98 0.00354051563957721 99 4525169
SGTC_2188 6126565 140.678 µM 2.68934622634177 0.0053067614159382 no 99 0.00357960614765565 66 874518
SGTC_81 0411-0046 9.971 µM 2.68325993585025 0.00539860271931071 no 100 0.00364541491026991 88 12925265
SGTC_835 0312-0010 67.2 µM 2.68125527378104 0.00542916065557435 no 101 0.00366732704008302 63 1626196
SGTC_427 1354-0053 47.3 µM 2.6727987176142 0.00555976647071554 no 102 0.00376106848162243 97 6813657
SGTC_2794 7785382 27.27 µM 2.64492753407408 0.00601019387262212 no 103 0.00408542067038671 133 2205081
SGTC_976 1348-1067 47.6 µM 2.63858669466234 0.00611707755564608 no 104 0.00416262052665908 117 5310671 YGL099W LSG1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.63739014078257 0.00613743497873389 no 105 0.00417733411308721 68 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3171 9103192 49.47 µM 2.60927961625102 0.00663327553388361 no 106 0.00453665344381239 45 13018434
SGTC_2896 9052656 71.43 µM 2.588614120823 0.00702005821720197 no 107 0.00481815054452936 266 6469436
SGTC_1700 st030840 7.9285 µM 2.56606467311553 0.00746468714552236 no 108 0.00514298239937613 96 5499307
SGTC_315 k915-0449 187 µM 2.5588630241693 0.00761182444775871 no 109 0.00525075552259195 153 20970215 YNL149C PGA2
SGTC_1679 SEC14.276 6.7 µM 2.5524348637349 0.00774530940917664 no 110 0.00534864547499398 165 1005053 YMR079W SEC14
SGTC_184 1494-0393 24.714 µM 2.54009206928438 0.00800740139013137 no 111 0.00554116453841813 171 3090647
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.5297207438057 0.00823362665784875 no 112 0.00570766709274348 191 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2780 5215298 71.43 µM 2.52783439463733 0.00827537082366332 no 113 0.00573842363882772 150 2834131
SGTC_96 0929-0093 37.281 µM 2.52031755395867 0.00844356729214017 no 114 0.00586245017643151 89 6991579
SGTC_1133 3473-0247 50 µM 2.51333192319285 0.00860255980540723 no 115 0.00597983756763619 163 711311
SGTC_245 methotrexate 289.6 µM 2.50108551706361 0.00888763155384749 no 116 0.00619066385491625 136 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3356 9151811 4.48 µM 2.49265062615907 0.0090887618854213 no 117 0.00633967691616623 112 1859254 YPR165W RHO1
SGTC_1148 3909-7663 27.7 µM 2.48906238338821 0.00917552497960229 no 118 0.00640402448017049 101 4084526
SGTC_747 3448-8087 38.7 µM 2.46691586131193 0.00972724160517457 no 119 0.00681411881310919 143 5168703
SGTC_3058 9093861 49.47 µM 2.46367407571933 0.00981038635785089 no 120 0.00687605493830045 127 17217477
SGTC_767 0929-0023 86 µM 2.45784280733554 0.00996150906316595 no 121 0.00698871696160804 239 1204563
SGTC_3031 9088762 49.47 µM 2.44922921609288 0.0101884554613554 no 122 0.00715811549364374 121 205253
SGTC_39 0986-0283 58.349 µM 2.44289976356218 0.0103580828904955 no 123 0.00728489166029537 160 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1010 4112-3296 15.2 µM 2.42745335811301 0.0107824138331151 no 124 0.00760262091956233 130 704384
SGTC_334 1502-1024 68.5 µM 2.4230719802574 0.0109054975298124 no 125 0.00769493848182636 123 3296216
SGTC_1335 1486-0900 202 µM 2.41945640750059 0.0110079868840025 no 126 0.00777186183617381 146 X1335
SGTC_2082 5219693 150 µM 2.41710763530391 0.0110750147693704 no 127 0.0078221951225279 139 2834649
SGTC_1105 epirubicin 18.1 µM 2.40501264128428 0.0114258238557985 no 128 0.00808595318107238 119 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.40487194850077 0.0114299607376058 no 129 0.00808906674000355 211 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2544 sphondin 68.51 µM 2.40119132010859 0.0115386479110371 no 130 0.00817089498025964 130 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_951 1171-0579 82.7 µM 2.39958372845245 0.011586400234509 no 131 0.00820686278834307 240 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_51 1013-0126 23.419 µM 2.39483801808006 0.011728370389636 no 132 0.00831385460429493 116 1627850
SGTC_2770 toltrazuril 17.5 µM 2.3895006645559 0.0118898414616642 no 133 0.00843564666959537 144 68591 Kills coccidiodes.
SGTC_750 4073-0104 132 µM 2.38925486692629 0.0118973238080501 no 134 0.00844129300638137 93 22330957
SGTC_1017 4239-0030 168 µM 2.38908840468869 0.0119023934185844 no 135 0.00844511877503427 154 1149593
SGTC_1468 k284-1086 134 µM 2.38184122079118 0.0121249308144594 no 136 0.0086131615885638 193 15996457
SGTC_2743 auranofin 4.32 µM 2.36953982164263 0.0125109278662083 no 137 0.00890511852328593 137 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_922 1866-0035 480 µM 2.35333041732693 0.0130357662146099 no 138 0.0093030462989695 222 3156169
SGTC_2679 rapamycin 1 nM 2.35264372214288 0.0130584145572612 no 139 0.00932024231933905 307 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_248 streptozotocin 5.23457 mM 2.351064016409 0.0131106450232538 no 140 0.00935990645878721 140 5300 DNA alkylating agent.
SGTC_2365 9042475 200 µM 2.35017771224107 0.0131400282577536 no 141 0.0093822248841634 155 6464479
SGTC_114 0364-0001 490.298 µM 2.34193897542372 0.0134158973148318 no 142 0.00959192566067182 185 4003655
SGTC_2344 7990960 76.95 µM 2.32710801320174 0.0139251193067678 no 143 0.00997975856716393 139 140813
SGTC_3066 9117245 49.47 µM 2.3253716871257 0.0139858121111753 no 144 0.0100260470329101 138 17176980
SGTC_2461 5755302 26.15 µM 2.31620045789094 0.0143101869536407 no 145 0.0102736631041783 170 2788904
SGTC_2005 4024620 188 µM 2.31150824403548 0.0144786357514268 no 146 0.0104023991651886 141 236743
SGTC_2026 5148700 152 µM 2.31138559686119 0.0144830615351571 no 147 0.0104057828989674 143 79838
SGTC_367 0335-0881 7.1 µM 2.30482294696767 0.0147215823961948 no 148 0.0105882456986327 219 23828853
SGTC_1184 1269-1718 139 µM 2.3029456114352 0.0147904330615488 no 149 0.0106409517088027 130 5403821
SGTC_2845 9003024 42.97 µM 2.28704532626088 0.0153847571706433 no 150 0.0110965887988287 208 2990173
SGTC_812 4251-0442 148 µM 2.28487545976087 0.0154674319645546 no 151 0.0111600656798041 110 5723007
SGTC_347 4534-1311 26.2 µM 2.28301304275622 0.0155386963939003 no 152 0.0112148000467526 138 2862016
SGTC_858 0438-0351 2.77 µM 2.27418713439746 0.0158802595917676 no 153 0.011477368729811 166 2799119
SGTC_1868 st057644 42.7 µM 2.26356936412295 0.0162996807979499 no 154 0.0118003069424763 176 688665
SGTC_857 0438-0306 1.35 µM 2.25135356506226 0.0167939300914078 no 155 0.0121815763383213 122 4686136
SGTC_1934 st074720 32.6 µM 2.25026385155287 0.0168386360410685 no 156 0.0122161005840704 220 17250992
SGTC_1446 4239-0190 62 µM 2.24394941996079 0.0170996967674795 no 157 0.0124178279474791 196 1340085
SGTC_1232 0279-0259 161 µM 2.23880291300226 0.0173150226173928 no 158 0.0125843713332464 163 1560000
SGTC_2019 4016004 108 µM 2.23141633987703 0.0176281160809771 no 159 0.0128267817479077 164 45595336
SGTC_2825 7998094 58.44 µM 2.23110376952148 0.0176414708243281 no 160 0.0128371280621946 169 2987815
SGTC_2109 5483026 200 µM 2.22894275966417 0.0177340375930707 no 161 0.0129088567859406 178 759335
SGTC_1632 st005650 90 µM 2.21770827512903 0.018221970893191 no 162 0.0132873648312717 168 2759605
SGTC_2582 agaric acid 100 µM 2.21731248006315 0.0182393675506653 no 163 0.0133008728288316 597 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1872 amphotericin b 148 nM 2.21124642301952 0.0185077688821861 no 164 0.0135093886247608 168 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3234 9132280 49.47 µM 2.19752222826336 0.0191274507310773 no 165 0.0139915853727588 178 17612295
SGTC_3199 9111318 49.47 µM 2.18805346050417 0.0195651990878594 no 166 0.0143328541894783 176 8548020
SGTC_1372 2752-0194 270 µM 2.18351560695459 0.0197779852739331 no 167 0.0144989304505467 140 823334
SGTC_1250 0485-0349 40.2 µM 2.18074211784299 0.0199090026959428 no 168 0.0146012479685743 196 6842794 YDL195W SEC31
SGTC_2805 7950783 58.44 µM 2.17210347294859 0.0203218141655375 no 169 0.0149239295440342 199 1178958 YDL195W SEC31
SGTC_2230 bromochlorosalicylanilide 954.5 nM 2.16105666092614 0.0208602550909155 no 170 0.0153454814084212 86 77254
SGTC_228 caffeine 993.056 µM 2.15236661056996 0.0212922661366338 no 171 0.0156842456554969 133 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_170 4197-0004 226 µM 2.14694768109218 0.0215654705651607 no 172 0.0158987235198424 136 218692
SGTC_1803 st050068 52.4 µM 2.12904575422646 0.0224891760199676 no 173 0.0166252375539716 446 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1019 4262-0212 3.4 µM 2.12586282225253 0.0226568541710313 no 174 0.0167573416392022 263 4677213
SGTC_1003 4049-0218 100 µM 2.12529167450414 0.0226870537086491 no 175 0.0167811412713629 228 295161
SGTC_2197 6588183 93.1375 µM 2.12454024798669 0.0227268371934581 no 176 0.0168124971276034 138 884136
SGTC_666 0272-0154 136 µM 2.12304679816629 0.0228060808870497 no 177 0.0168749652488856 247 6870312
SGTC_3264 9137442 49.47 µM 2.12054535791323 0.0229393309327928 no 178 0.0169800403168424 135 17015726
SGTC_17 0960-0276 49.807 µM 2.11809554762104 0.0230704657392865 no 179 0.0170834882699736 226 6821114
SGTC_1263 0774-1208 64.8 µM 2.1171521065578 0.0231211348685691 no 180 0.0171234703020958 260 906585
SGTC_317 4495-0002 170 µM 2.11491140733959 0.0232418511372005 no 181 0.0172187493796155 159 15991618
SGTC_2080 5212524 12.4 µM 2.11432730486319 0.0232734063262205 no 182 0.0172436609020863 147 260183
SGTC_1429 4049-0205 9.46 µM 2.1131457623777 0.0233373475008347 no 183 0.017294146931698 186 22774478
SGTC_975 1335-0046 28.5 µM 2.11217227824013 0.0233901402695604 no 184 0.0173358376727053 225 16486740
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.10256546442024 0.0239165349250561 no 185 0.017751885747325 201 688751
SGTC_3098 9119039 49.47 µM 2.09976390603544 0.0240719054902385 no 186 0.0178748073989409 199 17161528
SGTC_2251 lansoprazole 556 µM 2.09949617071008 0.0240867980150322 no 187 0.0178865925131631 150 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_796 1234-0020 70.7 µM 2.0964238873381 0.0242582456095349 no 188 0.0180223026136227 196 46495034
SGTC_1037 k284-1091 78.7 µM 2.09614837136063 0.0242736706226803 no 189 0.0180345155937481 169 3334711
SGTC_1229 0139-0193 12.2 µM 2.09091143475179 0.0245684350701346 no 190 0.0182680019385096 195 3090752
SGTC_1000 4048-0884 8.67 µM 2.08838210367405 0.0247118724198954 no 191 0.0183816902625769 207 13040088
SGTC_295 k015-0027 31 µM 2.08206740593594 0.0250730454734934 no 192 0.0186681566076823 176 3887424
SGTC_964 1287-0107 19.4 µM 2.07797446107762 0.0253094993920035 no 193 0.0188558557268853 238 51516812 YPR165W RHO1
SGTC_78 0336-0123 156.75 µM 2.07690215481472 0.0253717556288951 no 194 0.0189052954225672 170 6765896
SGTC_1974 st069448 26.9 µM 2.07173453144961 0.025673580323142 no 195 0.0191451025613665 171 6323587 YNR016C ACC1
SGTC_1540 guanosine 70.6 µM 2.07151360729864 0.0256865505210535 no 196 0.0191554120816264 153 6802 Guanosine is a purine nucleoside
SGTC_2852 9023854 51.95 µM 2.07116722934039 0.0257068970060409 no 197 0.019171585458099 196 19798528
SGTC_2358 9037157 4 µM 2.05192493764174 0.0268585796282915 no 198 0.0200884789398806 217 2388925
SGTC_301 4119-0100 24.5 µM 2.04965018897489 0.0269975313269635 no 199 0.0201992895126896 274 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1471 k673-0312 37 µM 2.03714996593586 0.0277718492181318 no 200 0.0208175080214213 171 24099884
SGTC_2506 ethyl hematommate 54.16 µM 2.0286501800757 0.0283088625703103 no 201 0.0212469668134508 179 3940691 An allergen.
SGTC_2951 9072950 58.06 µM 2.01406926072861 0.0292501986144314 no 202 0.0220011311535176 238 16488155
SGTC_1435 4092-0789 56.7 µM 2.00787141702269 0.0296581288787229 no 203 0.02232847862417 190 2248285
SGTC_306 1672-3436 11.6 µM 2.00105122948718 0.0301124652391661 no 204 0.0226934346853068 207 6797378
SGTC_3350 9150499 3.57 µM 1.99974967884449 0.0301998222223848 no 205 0.0227636504128383 280 4910996 YPR165W RHO1
SGTC_981 1488-1094 54.9 µM 1.99619810628684 0.0304392645156537 no 206 0.0229561817555833 167 3449522
SGTC_195 4234-0266 16.654 µM 1.99002910739969 0.0308589080705602 no 207 0.0232938645930169 268 2303354
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.9839037057669 0.0312803127722147 no 208 0.0236332878692997 230 390807
SGTC_1341 1486-1360 280 µM 1.97726967616332 0.0317420660801471 no 209 0.0240055777083176 232 3976547
SGTC_2818 7996756 12.99 µM 1.97479754220119 0.0319155699494742 no 210 0.0241455640422479 154 2241621
SGTC_671 0560-0003 407 µM 1.97387149420411 0.031980764897458 no 211 0.0241981784104129 202 3238678
SGTC_1314 1222-0010 41.1 µM 1.97029322767471 0.0322337136848671 no 212 0.0244023870759665 201 3526027
SGTC_2467 5474540 200 µM 1.96867596481121 0.0323485791341356 no 213 0.0244951565277231 240 5413519
SGTC_2025 5147754 141 µM 1.96615704840226 0.0325281567332495 no 214 0.0246402361139076 182 315777 YLR208W SEC13
SGTC_2502 avocadyne acetate 18.59 µM 1.96374417944267 0.0327009443654944 no 215 0.024779883204888 274 3952079
SGTC_2277 7947813 106.88 µM 1.95060638036294 0.033655080958691 no 216 0.0255519438209209 253 1246798
SGTC_877 0771-0151 33.1 µM 1.94332852443636 0.0341934239996839 no 217 0.0259882385842441 238 6166523
SGTC_637 1181-0519 7.26 µM 1.94030219484345 0.0344193558648987 no 218 0.0261714874016653 367 6252091 YGR060W ERG25
SGTC_2956 9076196 2.52 µM 1.93622559721389 0.0347256335343263 no 219 0.0264200383668065 236 16423868
SGTC_776 4476-4378 112 µM 1.93538709334333 0.0347889076197297 no 220 0.0264714059677238 204 2892008
SGTC_3299 9121982 43.1275 µM 1.92837462585593 0.0353217878029478 no 221 0.0269042728071134 250 17594604 YPL160W CDC60
SGTC_734 2023-0417 80 µM 1.91881209156724 0.0360592193469974 no 222 0.0275040595201756 239 3935732
SGTC_673 1082-0474 110 µM 1.91632972481529 0.0362526991371603 no 223 0.0276615698086402 337 3098046
SGTC_583 1488-1091 88.9 µM 1.91111657111547 0.0366617878825504 no 224 0.0279948010296126 301 4303273
SGTC_2146 5545642 200 µM 1.90795621000487 0.0369116222167434 no 225 0.0281984381381859 211 825326
SGTC_71 0417-1750 47.813 µM 1.90630922586536 0.0370423710629456 no 226 0.0283050489854389 288 6811472
SGTC_731 3966-0296 387 µM 1.90084533359777 0.0374788456400407 no 227 0.0286611370899032 241 660956
SGTC_107 0358-0022 2.6945 µM 1.89859498147314 0.0376598284960888 no 228 0.0288088743847355 157 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1711 st032263 62.8 µM 1.89615949833884 0.0378565036445535 no 229 0.0289694784866567 223 3958979
SGTC_2649 anisomycin 9.56 µM 1.89518988701489 0.0379350366077888 no 230 0.0290336247340778 179 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_579 4491-1009 110 µM 1.8926523670002 0.0381411904875491 no 231 0.0292020573988056 339 1271041
SGTC_974 1326-0144 138 µM 1.88451023782005 0.0388088526851419 no 232 0.0297479956540358 292 5411856
SGTC_1892 st058411 7.36 µM 1.87703018279917 0.0394305849238866 no 233 0.0302569786028727 297 3934738
SGTC_196 k015-0023 18.111 µM 1.87440909148673 0.039650354423087 no 234 0.0304370306843522 267 5211998
SGTC_1316 1272-0050 65.9 µM 1.86783467277295 0.0402059815718009 no 235 0.0308925594501505 218 7340392
SGTC_923 1900-2434 73.3 µM 1.8632145196242 0.040600218202571 no 236 0.03121604543703 273 5910570
SGTC_14 0354-0009 295 µM 1.85078799051976 0.0416761578448118 no 237 0.0321000297347298 265 1713507
SGTC_1484 3473-2379 286 µM 1.85066094705151 0.0416872759074371 no 238 0.032109172841495 297 671917
SGTC_2520 obtusaquinone 4.71 µM 1.84968970492692 0.0417723524513047 no 239 0.0321791425901598 240 5967872
SGTC_218 alverine citrate 93.75 µM 1.84778479718713 0.0419396223272556 no 240 0.0323167405331881 227 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1025 k007-0731 70 µM 1.84760849341029 0.041955130932972 no 241 0.0323295000643615 258 6256118
SGTC_1683 st010134 710 nM 1.84640400486936 0.0420612083158901 no 242 0.0324167830788312 293 3818134
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.8437727835525 0.0422936908973328 no 243 0.0326081303528215 319 442882
SGTC_1389 3405-0187 19 µM 1.83854656340685 0.042758538499698 no 244 0.0329909535610291 260 799890
SGTC_3035 9091303 49.47 µM 1.83641949149413 0.0429489101220854 no 245 0.033147819508175 197 25237002
SGTC_1651 st011928 86.1 µM 1.83037192254773 0.0434939077118112 no 246 0.033597171622391 244 720198
SGTC_2842 9000675 19.48 µM 1.82658201323998 0.0438382845305589 no 247 0.0338813199058041 263 2989072
SGTC_1548 st061468 90.8 µM 1.82372346135466 0.0440994843470262 no 248 0.0340969450475256 231 390799
SGTC_3167 9103034 49.47 µM 1.82322976538885 0.0441447225666664 no 249 0.034134299342013 183 5127859
SGTC_1864 st057645 30.4 µM 1.81451557331269 0.0449493946384887 no 250 0.0347991936717264 224 688666
SGTC_1077 5-fluorocytosine 377 nM 1.81040655435528 0.0453328981019951 no 251 0.0351163818128202 257 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1076 itraconazole 331 nM 1.80832887138371 0.0455278121332226 no 252 0.0352776654781942 277 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2804 7954240 19.48 µM 1.80699432897287 0.0456533648305698 no 253 0.0353815817143834 311 828705
SGTC_2166 5933061 31.504 µM 1.8065406329902 0.0456961115340433 no 254 0.0354169665888218 294 2877375
SGTC_600 1495-0418 41.6 µM 1.80488904675852 0.0458519938573766 no 255 0.0355460230690646 267 5377768
SGTC_2645 abamectin 100 µM 1.8032366277368 0.046008382140331 no 256 0.0356755301980836 299 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_356 1634-0012 32.5 µM 1.80289992593718 0.0460403007738133 no 257 0.035701966325648 303 735457
SGTC_3152 9099253 49.47 µM 1.80259363824226 0.0460693516616385 no 258 0.035726028433988 426 25236131
SGTC_312 4092-0653 6.84 µM 1.80129668947542 0.0461925283550608 no 259 0.0358280646816882 403 1148278
SGTC_229 benomyl 22.8748 µM 1.79832287593701 0.046475962543727 no 260 0.0360629283222477 296 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2985 9022375 71.43 µM 1.79688490474475 0.0466135154024933 no 261 0.036176946773757 293 4939335
SGTC_1237 0330-0133 46.1 µM 1.79677230501969 0.0466243001983494 no 262 0.0361858873873752 275 X1237 YHR072W ERG7
SGTC_2949 9072542 2.23 µM 1.79222449582656 0.0470615652541318 no 263 0.0365485061441483 342 16457352
SGTC_2895 9054447 58.44 µM 1.79215998663869 0.0470677912854122 no 264 0.036553671079644 239 2697450
SGTC_2617 dihydrotanshinone i 20.83 µM 1.79144692832455 0.0471366553050822 no 265 0.0366108019668712 335 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_422 cantharidin 155 µM 1.78638430728132 0.0476279062381358 no 266 0.037018527360735 362 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_942 3253-1115 227 µM 1.78531761146627 0.0477319341679735 no 267 0.0371049069033426 298 46497897
SGTC_2524 avocatin b 10.57 µM 1.78266641484606 0.0479912763816505 no 268 0.0373203107723165 248 6710748
SGTC_2137 5261020 140 µM 1.78198552923107 0.0480580628644685 no 269 0.0373757957826024 298 763655
SGTC_129 0088-0017 176.636 µM 1.77890898319986 0.0483607619515866 no 270 0.0376273425521799 327 182446
SGTC_27 0485-0001 32.618 µM 1.77783576190237 0.0484667134715495 no 271 0.0377154165535767 189 2054479
SGTC_2705 st078069 42.8 µM 1.77544053137796 0.0487038470362135 no 272 0.0379125883058413 252 1530061
SGTC_2835 9006588 71.43 µM 1.76994931378784 0.0492509912793256 no 273 0.0383677923683547 331 2345538
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.7585100478275 0.0504065574725381 no 274 0.0393303817251509 367 65057 A dermal irritant. YDR527W RBA50
SGTC_3219 9131112 49.47 µM 1.75416377648872 0.0508512302239284 no 275 0.0397012240701334 290 17612988 YMR079W SEC14
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.74939873162622 0.0513423314234188 no 276 0.0401110599858294 288 2346 DNA damaging agent; causes G2/M arrest.
SGTC_710 3448-4187 58 µM 1.74891956206234 0.0513919242734691 no 277 0.0401524623157012 416 3946412
SGTC_2657 nystatin 74.44 µM 1.74439104388981 0.0518624983222306 no 278 0.0405454628204374 302 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_264 promethazine 12.5 mM 1.73985031917047 0.052337772461861 no 279 0.0409426520788877 436 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2855 9016525 58.44 µM 1.73772497049895 0.0525614160567629 no 280 0.0411296433167343 313 43811474
SGTC_3240 9133527 49.47 µM 1.73726271426906 0.0526101580714413 no 281 0.0411704048329427 281 17617455
SGTC_820 1582-0060 59.9 µM 1.73574760119499 0.0527701687336013 no 282 0.0413042363842891 342 3848840
SGTC_1100 amiodarone 5.07 µM 1.7344791604547 0.0529044251249118 no 283 0.0414165501058591 328 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2445 5742597 35.57 µM 1.72852273559328 0.053538501779634 no 284 0.041947274247327 306 1774255
SGTC_2315 7733312 200 µM 1.72453631492904 0.053966219217376 no 285 0.0423055345083191 283 726316
SGTC_1115 galangin 695.678 nM 1.72331674218124 0.054097610575065 no 286 0.0424156308835575 345 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_363 0455-0021 3.06 µM 1.71930564226768 0.0545315351377575 no 287 0.0427793665627468 374 4597466
SGTC_2363 9053361 176 µM 1.71414989557734 0.0550933263200934 no 288 0.0432506000702732 340 6469797 YMR079W SEC14
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.70934655211615 0.0556208232445715 no 289 0.043693387512345 308 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2078 5212016 200 µM 1.70716755305807 0.0558614287249652 no 290 0.043895457006778 271 1899708
SGTC_2156 5649887 115 µM 1.70668775368661 0.0559145184129978 no 291 0.0439400523088445 357 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1827 berberine 7.24 µM 1.70453316543549 0.0561534139504109 no 292 0.0441407627410796 306 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_351 caspofungin 25 nM 1.70305052381565 0.0563182726248689 no 293 0.0442793068803863 471 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2110 5483698 200 µM 1.69979860295618 0.0566811979948148 no 294 0.0445844072074406 304 2848765 YHR062C RPP1
SGTC_1461 k072-0203 53.8 µM 1.69762433523174 0.0569248796361743 no 295 0.044789343409045 308 5418714
SGTC_419 nsc-638432 893 µM 1.68426450085907 0.0584403401754223 no 296 0.0460652813552775 329 368090
SGTC_586 0957-0265 8.15 µM 1.6841830986967 0.0584496701240073 no 297 0.0460731442781251 252 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1260 0700-1617 7.75 µM 1.68342668494887 0.0585364227989662 no 298 0.0461462605226679 367 2853078
SGTC_1687 st020778 55.3625 µM 1.68326138692732 0.0585553941914196 no 299 0.0461622509129299 513 4259299
SGTC_662 k832-1615 104 µM 1.67594478515714 0.059399972724891 no 300 0.0468745041551952 322 5878478
SGTC_2294 7971431 200 µM 1.67245698125982 0.0598059279861993 no 301 0.0472171219905377 275 5741572
SGTC_704 1310-0270 142 µM 1.67237135729713 0.0598159212639494 no 302 0.0472255582757622 383 5718033
SGTC_919 tnp00227 403.569 nM 1.67125145059272 0.0599467474241685 no 303 0.047336010772705 381 1269246 A methoxyflavone. YNL221C POP1
SGTC_3130 9127414 49.47 µM 1.66734649506276 0.0604046732840922 no 304 0.0477227631923537 299 1494646
SGTC_2018 5133068 143 µM 1.66497768773721 0.0606837894019112 no 305 0.0479586036840655 345 785362
SGTC_1436 4092-1007 8.32 µM 1.66168446085082 0.0610735045643203 no 306 0.0482880292121187 316 2881121
SGTC_1385 3091-4834 14.1 µM 1.66097010511931 0.0611582979022622 no 307 0.048359725458556 315 4072814
SGTC_1917 st066507 28.5 µM 1.65698764043792 0.0616326998760748 no 308 0.0487609869639229 401 3156428
SGTC_2639 lactacystin 53 µM 1.65650345756146 0.0616905724281636 no 309 0.0488099527228309 362 3870 A proteasome inhibitor.
SGTC_1656 st012921 11 µM 1.65032427432632 0.0624328781517293 no 310 0.0494383150148057 300 6732821
SGTC_1970 st070122 35.8 µM 1.64818341035287 0.062691678586205 no 311 0.0496575200289347 368 102928
SGTC_291 SEC14.278 35.5 µM 1.64047033560043 0.0636310184316326 no 312 0.0504537057250717 345 1068044
SGTC_499 genistein 192 µM 1.63444031543324 0.0643729852950611 no 313 0.0510832144268068 248 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2849 9019321 12.99 µM 1.63340439911661 0.0645011241078373 no 314 0.0511919862204006 339 16489627
SGTC_1723 st034307 2.5525 µM 1.63285474227699 0.0645691949361692 no 315 0.0512497752839591 356 867466
SGTC_834 0312-0008 75.7 µM 1.62487707432869 0.0655634626502435 no 316 0.0520943770114234 407 6385573 YIL048W NEO1
SGTC_313 3474-0040 5.03 µM 1.62139366158179 0.0660013113673896 no 317 0.0524666196323536 437 1043375 YIL048W NEO1
SGTC_94 0334-0113 514.748 µM 1.62009130459626 0.0661655922129476 no 318 0.0526063325111752 365 6795178
SGTC_2719 novobiocin 32.65 µM 1.61952435234355 0.066237207117483 no 319 0.0526672455879934 240 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2093 5331342 194.4 µM 1.61374542321891 0.0669706046075405 no 320 0.0532913284827703 363 33839
SGTC_146 3448-8650 53.125 µM 1.61283345210701 0.067086913482255 no 321 0.0533903481442791 540 2891488 YIL048W NEO1
SGTC_904 1141-0088 396 µM 1.61168395797942 0.0672337374859481 no 322 0.0535153651438201 352 1378119
SGTC_278 4092-0821 23.9 µM 1.6077633886891 0.0677363779522636 no 323 0.0539435048176229 352 877900
SGTC_1048 3161-0300 24.5 µM 1.60490504948178 0.0681046601015577 no 324 0.0542573510723801 393 2165101
SGTC_3144 9087057 49.47 µM 1.60216867071851 0.0684586746505117 no 325 0.0545591579794172 377 17249618
SGTC_311 1315-0136 58 µM 1.5988158365923 0.0688943755772009 no 326 0.0549307645713869 346 6759207
SGTC_1157 4092-0394 27.6 µM 1.5971029610669 0.0691177872588687 no 327 0.0551213791292716 419 3659885
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.59592937776446 0.0692711806436423 no 328 0.0552522808234234 404 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1927 st060202 13.8 µM 1.59202993286488 0.0697827419728459 no 329 0.0556889895139514 352 688887
SGTC_59 0330-0160 1.33 µM 1.5907471924508 0.0699516565089199 no 330 0.0558332407984518 551 4293482
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.58711052579116 0.0704322525054987 no 331 0.0562438071843985 371 688662
SGTC_2357 9067248 200 µM 1.58508847614241 0.070700568141255 no 332 0.0564731167407261 351 9150235
SGTC_481 bay k-8644 50 µM 1.58458914398155 0.0707669477435078 no 333 0.0565298565451729 367 2303 A calcium channel antagonist.
SGTC_2755 lomerizine 42.69 µM 1.58224589588814 0.0710790913708904 no 334 0.056796723332593 401 3949 A calcium channel blocker.
SGTC_2140 5586273 200 µM 1.57894119347487 0.0715211058211567 no 335 0.0571747731120721 317 854421
SGTC_1064 honokiol 6.76 µM 1.57269872616725 0.0723618068798581 no 336 0.0578942974754101 394 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2700 st077718 96.8 µM 1.57164293572713 0.072504740499275 no 337 0.0580166915516318 331 904970
SGTC_1447 4239-0816 81.9 µM 1.56972377666939 0.0727651112823002 no 338 0.0582396936023652 370 1341554
SGTC_3242 9133940 49.47 µM 1.56527049702474 0.073372041672759 no 339 0.0587597488941499 365 17248444
SGTC_789 1309-1135 70.6 µM 1.56164904987506 0.0738684514868872 no 340 0.0591853438195435 431 3092424
SGTC_259 usnic acid 108.925 µM 1.55832777094661 0.0743259683265291 no 341 0.0595777845075823 397 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1355 1499-0035 1.68 µM 1.55724995678091 0.0744749047911525 no 342 0.0597055758520193 386 1548538
SGTC_784 4579-0127 173 µM 1.55581367741278 0.0746737292987789 no 343 0.0598762023963649 407 1948547
SGTC_1477 0139-0234 16 µM 1.55400663380918 0.0749244538983006 no 344 0.0600914171286175 363 620880
SGTC_2662 daunorubicin 22.37 µM 1.55300505197319 0.0750636982068966 no 345 0.0602109638404648 337 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1287 0971-0001 34.6 µM 1.55107168398258 0.0753330415527507 no 346 0.0604422530628342 451 4665869
SGTC_1799 st045822 46.1415 µM 1.54378999314623 0.0763540912407699 no 347 0.0613196081682106 376 3674992
SGTC_841 0251-0215 91.2 µM 1.54318562530851 0.0764393075987868 no 348 0.061392872009866 476 3888614
SGTC_3311 9131146 2.8755 µM 1.54274314763407 0.0765017431775403 no 349 0.0614465542347531 452 4900406 YPR165W RHO1
SGTC_2249 haloperidol 116.36 µM 1.54258639817661 0.0765238705303242 no 350 0.0614655801666592 537 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_736 0958-0254 92.6 µM 1.54237938450192 0.0765531008322469 no 351 0.0614907141182862 425 6812352
SGTC_1440 4100-1550 40 µM 1.54058933233388 0.0768062102753017 no 352 0.0617083829265572 323 742806
SGTC_2753 fluvastatin 17.09 µM 1.53681962010931 0.0773413195067742 no 353 0.0621687437075252 441 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_794 k038-0031 316 µM 1.53543040041303 0.0775392312239296 no 354 0.0623390705257223 504 6624242
SGTC_1766 st045414 44.774 µM 1.5345347750185 0.077667027993042 no 355 0.0624490724631824 441 253960
SGTC_3272 9137413 49.47 µM 1.53321170762326 0.0778561089513561 no 356 0.0626118502678469 380 17614870
SGTC_3100 9120536 49.47 µM 1.53116312301691 0.0781495632718773 no 357 0.06286454115766 278 16421196
SGTC_2185 6113692 200 µM 1.52766589527436 0.0786524694893625 no 358 0.0632977559403244 376 874150
SGTC_2150 5556613 200 µM 1.52074157268157 0.0796554267596439 no 359 0.0641623508671968 439 743190
SGTC_3197 9113331 49.47 µM 1.51953714955218 0.0798308656304518 no 360 0.064313672215184 437 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2370 9071495 200 µM 1.51941337575257 0.0798489113354594 no 361 0.0643292386134485 410 21791103
SGTC_2821 7996764 71.43 µM 1.51924204175791 0.0798738962098092 no 362 0.0643507912458386 443 2987135
SGTC_2381 9035592 200 µM 1.50939287429234 0.0813201162055165 no 363 0.0655992064897572 349 4749657
SGTC_447 ml7 120 µM 1.50845900961103 0.0814582605998482 no 364 0.065718545027715 415 4216 Selective myosin light chain kinase inhibitor.
SGTC_126 0417-1624 672.48 µM 1.50704478458624 0.0816678004200424 no 365 0.0658995891291076 514 41912 YDL195W SEC31
SGTC_2386 9075165 157.42 µM 1.50605579696749 0.0818145758651815 no 366 0.066026425322967 377 16452277
SGTC_1278 0874-0585 172 µM 1.5035321902774 0.0821900046609727 no 367 0.0663509312185543 408 766306
SGTC_3344 9148862 3.898 µM 1.50319006998769 0.0822410005101 no 368 0.0663950187288302 399 4905352
SGTC_365 0121-0052 13.6 µM 1.50201544409924 0.082416269553878 no 369 0.0665465601507279 506 3101739
SGTC_2891 9063876 19.48 µM 1.49634611241944 0.0832661618064245 no 370 0.0672817422001467 322 6472478
SGTC_2107 5363541 170.161 µM 1.48921036238123 0.0843452306173061 no 371 0.068215991468565 435 244052
SGTC_2688 kanamycin b 96.69 µM 1.4891433584717 0.0843554124500821 no 372 0.0682248111749088 968 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_558 k064-0027 21.3 µM 1.48723666032816 0.084645538683168 no 373 0.0684761583630827 430 5088526
SGTC_1959 st077091 55.8 µM 1.48603387896047 0.0848289403852277 no 374 0.0686350800089506 457 821356 YKL052C ASK1
SGTC_1857 st056007 79.3 µM 1.48590993641619 0.0848478562290856 no 375 0.0686514724991942 374 619834
SGTC_933 2914-0560 114 µM 1.47931046582596 0.0858596264108889 no 376 0.0695286784917789 478 463887
SGTC_1043 0916-0009 19.3 µM 1.47585518020854 0.0863929474600439 no 377 0.0699913868485389 521 3101130
SGTC_67 0335-0847 266 µM 1.47570407736822 0.0864163264878705 no 378 0.0700116754531304 599 4552207 YOR254C SEC63
SGTC_1374 2889-5571 141 µM 1.47482301732016 0.0865527406255201 no 379 0.0701300656616093 491 2853281
SGTC_2010 4012422 159 µM 1.47102398403015 0.0871427871337642 no 380 0.0706423153950006 439 952393
SGTC_3303 9125618 40.5795 µM 1.46992143391159 0.0873145907173422 no 381 0.0707915168734716 532 22695467
SGTC_1659 st012954 42.1 µM 1.46833611357235 0.0875620644175934 no 382 0.0710064729439395 411 24207262
SGTC_1655 st012546 55.1 µM 1.46692135285612 0.087783354840106 no 383 0.0711987255577898 404 720985 YLR208W SEC13
SGTC_517 1365-0151 113 µM 1.46394012296595 0.0882510305291458 no 384 0.0716051546492847 432 768657
SGTC_1497 4476-2978 41.3 µM 1.46272048551302 0.088442893573182 no 385 0.0717719391679256 484 1528379
SGTC_3236 9132701 49.47 µM 1.4621591630316 0.0885313004392662 no 386 0.0718487996560166 427 24282524
SGTC_2178 5812956 200 µM 1.46169972953091 0.0886037090294891 no 387 0.0719117557041431 409 5403383
SGTC_1014 4130-3005 69.3 µM 1.461664593041 0.0886092484986664 no 388 0.0719165721885499 473 743608
SGTC_2189 6047310 154.431 µM 1.46102125447248 0.0887107201217876 no 389 0.0720048043065822 413 711535
SGTC_856 0433-0016 11.3 µM 1.46050799772801 0.0887917364190295 no 390 0.0720752555599687 470 3911780
SGTC_274 sirtinol 40.1 µM 1.45370139312578 0.0898713573508308 no 391 0.0730145558944009 446 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2285 7945142 200 µM 1.45353545857263 0.0898977981374181 no 392 0.0730375710205074 439 2970608
SGTC_3155 9099265 49.47 µM 1.45267474527056 0.0900350409908623 no 393 0.0731570410748828 399 25236499
SGTC_414 piperonyl butoxide 100 µM 1.45085712789521 0.0903253759579984 no 394 0.0734098240310912 413 5794 A potent inhibitor of cytochrome P450.
SGTC_2151 5563267 85.4165 µM 1.45068643581562 0.0903526769286737 no 395 0.0734335970984357 466 5310824
SGTC_1087 pterostilbene 9.05 µM 1.44907940676295 0.0906100101584995 no 396 0.0736577041366903 485 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1303 1160-0052 261 µM 1.44885127990764 0.0906465841159891 no 397 0.0736895597319923 445 3562476
SGTC_607 4491-0986 66.8 µM 1.44639980468436 0.0910403034938736 no 398 0.0740325483078484 486 698981 YDR232W HEM1
SGTC_402 epigallocatechin gallate 10 µM 1.4453360523024 0.0912115416029153 no 399 0.07418175796382 473 65064 An antioxidant.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.44504739666436 0.0912580492691147 no 400 0.0742222865000434 413 688803
SGTC_1733 st037357 54.9 µM 1.44328333343196 0.0915426540160724 no 401 0.0744703363884116 493 1272339 YGL099W LSG1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.44186717501644 0.0917716051835369 no 402 0.0746699239446514 449 4330530
SGTC_1493 4348-0038 111 µM 1.43456878057885 0.092958270288575 no 403 0.0757050081138098 491 800424
SGTC_2113 5491891 107.031 µM 1.43259014187248 0.0932819283682174 no 404 0.0759875003219206 473 789979
SGTC_2325 6158266 200 µM 1.43184764415371 0.0934035978761135 no 405 0.0760937143095614 452 3623240
SGTC_2791 5663188 71.43 µM 1.430657080055 0.0935989344733868 no 406 0.0762642598521516 437 54690634
SGTC_2264 7948757 110.76 µM 1.42815191001892 0.0940109441751316 no 407 0.0766240694599262 431 2971411
SGTC_1107 amlodipine 47 µM 1.42186114676306 0.0950514436980028 no 408 0.0775332821505663 476 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1074 carmofur 3.8 µM 1.42028996867481 0.0953126372595946 no 409 0.0777616401779603 516 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1809 st050081 57.6 µM 1.41833189660528 0.0956388874444363 no 410 0.0780469442403824 456 5036894
SGTC_438 sphingosine 6.67 µM 1.41824816332313 0.0956528572203274 no 411 0.0780591624166022 382 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_251 melphalan 456.522 µM 1.41257943452687 0.096602103488932 no 412 0.0788897097095457 536 460612 A DNA alkylator.
SGTC_13 0199-0087 65 µM 1.41008304251697 0.097022319819866 no 413 0.0792575818981775 483 4589825
SGTC_253 dyclonine 31.25 µM 1.40840878104309 0.0973048980967672 no 414 0.0795050302790015 523 3180 An oral anasthetic.
SGTC_1108 betulinic acid 729.144 nM 1.40737538174756 0.0974796141262184 no 415 0.0796580536082045 479 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1929 genistein trimethyl ether 50.5 µM 1.40343138284703 0.0981485378957526 no 416 0.0802441200718241 469 136420
SGTC_2737 bleomycin 30.5 nM 1.40105319691133 0.0985535130610991 no 417 0.0805990829583058 538 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1344 1488-0097 29.1 µM 1.39435652215319 0.0997004422897955 no 418 0.0816049852182757 480 747966
SGTC_762 1165-0429 115 µM 1.39404678304755 0.0997537258058153 no 419 0.0816517388854519 483 5967793
SGTC_2135 5326629 150.42 µM 1.39259326802731 0.100004047648785 no 420 0.0818714099478753 459 5020077
SGTC_2977 9011197 71.43 µM 1.39121939529962 0.100241075031146 no 421 0.08207945377439 407 2704722
SGTC_3110 9122132 49.47 µM 1.38937330609141 0.100560216908658 no 422 0.0823596315646646 484 918317
SGTC_1269 0831-0796 3.05 µM 1.38910340991031 0.100606937131517 no 423 0.0824006535123366 481 927758
SGTC_2952 9073731 13.78 µM 1.38686706308291 0.100994667927959 no 424 0.0827411514553138 520 16457353
SGTC_1199 1638-0010 4.46 µM 1.38175273917033 0.101885464973224 no 425 0.0835238174287123 527 3111136
SGTC_1653 st012112 65 µM 1.38077173207799 0.102056985409373 no 426 0.083674578837158 460 720429
SGTC_2250 alverine citrate 130 µM 1.37983244176418 0.102221408828511 no 427 0.083819120700789 646 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1600 coumarin 106 71.1 µM 1.37861193074134 0.102435347876052 no 428 0.0840072180275631 514 100336 A hepatotoxic, DNA x-linker.
SGTC_201 4262-0159 12.803 µM 1.37816515704794 0.102513742597332 no 429 0.0840761511071536 419 1341029
SGTC_1117 retinoic acid 1.10837 µM 1.37735360597448 0.102656255828911 no 430 0.0842014746024739 539 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_449 xestospongin c 11.1929 µM 1.37541730105629 0.102996864128269 no 431 0.0845010541258307 524 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1458 k015-0034 6.33 µM 1.37400303272032 0.103246161153346 no 432 0.0847203704562508 465 3598957
SGTC_105 0111-0055 734.78 µM 1.37288718588819 0.10344316357994 no 433 0.0848937104010015 404 5179370
SGTC_175 3793-3120 23.7 µM 1.36758272454749 0.104383396493414 no 434 0.0857213634860823 465 5322297
SGTC_1412 3909-8563 178 µM 1.36557642011541 0.104740629759644 no 435 0.0860359759053761 552 23767530
SGTC_2228 7354201 200 µM 1.36525345448914 0.10479821815619 no 436 0.0860867013876049 459 753451
SGTC_287 k060-0039 29.6 µM 1.36269959176438 0.105254408180361 no 437 0.0864886032795065 480 5861974
SGTC_2210 7115885 190.385 µM 1.36229501635338 0.105326808097029 no 438 0.086552399896907 523 2927039
SGTC_2267 7931562 200 µM 1.36099762489486 0.10555922297925 no 439 0.086757220017348 460 934880
SGTC_2212 7123476 200 µM 1.36019569837301 0.105703065542746 no 440 0.0868840017334469 404 1085715
SGTC_2987 9018338 71.43 µM 1.35605295442759 0.106448411928791 no 441 0.0875411599878343 511 5055682
SGTC_2970 9090938 41.86 µM 1.35443999308042 0.106739633633549 no 442 0.0877980228082537 598 17217104
SGTC_1244 0416-0015 52.5 µM 1.3442596200765 0.108590982378219 no 443 0.089432224154992 498 96201
SGTC_3270 9137563 49.47 µM 1.34423099253149 0.108596220795412 no 444 0.0894368512678998 447 17015724
SGTC_2561 acetosyringone 100 µM 1.34376825884278 0.108680919429821 no 445 0.0895116683088554 582 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_88 0180-0332 8.668 µM 1.33943269240251 0.109476808849409 no 446 0.090214926238201 516 3101745
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.33786488915561 0.109765641928312 no 447 0.0904702422316835 484 6708514
SGTC_1137 ixabepilone 100 µM 1.33630616659567 0.110053343937472 no 448 0.0907246108797325 583 154225 A novel microtubule stabilizer.
SGTC_902 1120-0002 2.07 µM 1.33468406390388 0.110353318405681 no 449 0.0909898857396717 551 3280475
SGTC_639 0833-0042 114 µM 1.33416851249203 0.110448781688712 no 450 0.0910743181846251 564 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_584 0986-0246 15.4 µM 1.33360613221008 0.110552983651004 no 451 0.0911664860982921 579 53315 YDR232W HEM1
SGTC_84 0443-0269 128.823 µM 1.33177310814083 0.110893108970778 no 452 0.091467378623657 529 6150058
SGTC_1078 idebenone 36.1 µM 1.32467852192115 0.112216603549923 no 453 0.092638899911816 596 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1575 cyproterone acetate 48 µM 1.32272209624564 0.112583552424402 no 454 0.0929639062827644 526 9880 An androgen receptor antagonist and liver toxin.
SGTC_1840 st055363 71 µM 1.32267550199233 0.112592302118752 no 455 0.0929716569010917 460 676033
SGTC_2191 5911152 200 µM 1.32262049871155 0.112602631526019 no 456 0.092980806915321 513 2875902
SGTC_1748 st037455 53.6035 µM 1.32025694019722 0.113047138431371 no 457 0.093374623430483 532 580690
SGTC_2335 9018011 154.17 µM 1.31939332399342 0.113209867936735 no 458 0.0935188262477312 577 6458208
SGTC_1456 k015-0012 13 µM 1.31894124922018 0.113295118106208 no 459 0.0935943772459821 611 2989616
SGTC_954 1189-0853 2.85 µM 1.31684170103768 0.11369164137933 no 460 0.0939458457424993 547 2828194
SGTC_879 0831-1030 162 µM 1.31560134795182 0.113926360334354 no 461 0.0941539404556402 607 1549252
SGTC_3332 9141069 11.198 µM 1.31244124934294 0.114525923379091 no 462 0.0946856483638992 475 17332883
SGTC_2428 5615643 7.78 µM 1.31037020523047 0.114920077231402 no 463 0.0950353139627472 521 2253075
SGTC_331 k048-0133 24.5 µM 1.30664552646869 0.115631371139421 no 464 0.0956665635644548 479 6813582
SGTC_377 3970-0964 33.1 µM 1.30524440474687 0.115899748186446 no 465 0.0959048191109875 641 16481235
SGTC_2874 9043904 71.43 µM 1.30521706903913 0.115904988583633 no 466 0.0959094717828639 433 4463428
SGTC_1704 st028805 70.8 µM 1.30341094882626 0.116251604062395 no 467 0.0962172502741102 526 2876101
SGTC_1936 st074407 74.3 µM 1.30288236747117 0.116353183962505 no 468 0.096307462286919 580 809813
SGTC_3179 9107801 49.47 µM 1.30164436578505 0.116591342836112 no 469 0.096518993039126 531 4818259
SGTC_1331 1472-0049 76.2 µM 1.30096621945799 0.116721946755931 no 470 0.0966350088907909 510 24051409
SGTC_2029 5175081 200 µM 1.30093239269354 0.11672846415343 no 471 0.096640798583718 587 1380876
SGTC_484 loperamide 105 µM 1.29993874021932 0.116920026137969 no 472 0.0968109830059974 436 3955 An opioid-receptor agonist.
SGTC_2434 5670830 169.91 µM 1.29971483962574 0.116963221711835 no 473 0.0968493611757166 548 1549830
SGTC_1021 4476-0760 85.3 µM 1.29909051153703 0.117083728690532 no 474 0.0969564344958524 548 746768
SGTC_1772 st048439 82.2 µM 1.29799215012329 0.117295946418256 no 475 0.0971450162141312 564 2927068 YDL195W SEC31
SGTC_1870 st057514 26.5 µM 1.29491223561474 0.117892478618522 no 476 0.0976752535502422 545 5393161
SGTC_1902 st060212 70.5 µM 1.29295096228822 0.118273464004993 no 477 0.0980140099557133 557 688944
SGTC_1402 3909-7673 35.9 µM 1.29167363526866 0.118522057622808 no 478 0.0982350957600408 531 5328014
SGTC_2396 5342950 42.78 µM 1.28801175181223 0.119236780087149 no 479 0.0988709361992964 599 1886677
SGTC_3217 9129673 49.47 µM 1.28539265925046 0.119749834210972 no 480 0.0993275525566069 551 17248312
SGTC_1898 st060199 18.6 µM 1.28116616194177 0.120581042275167 no 481 0.100067654394114 521 688866
SGTC_3026 9090633 49.47 µM 1.27780282624041 0.1212453923247 no 482 0.100659478818528 562 25236842
SGTC_960 1222-0186 7.7 µM 1.27764619511308 0.121276393830378 no 483 0.100687102268215 576 3126296
SGTC_1798 st045719 60.953 µM 1.27735376536764 0.121334288446927 no 484 0.100738689944928 514 3980186
SGTC_441 propafenone 146 µM 1.2734629307648 0.122106437427753 no 485 0.101426909287761 500 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2783 7738165 71.43 µM 1.2730180820637 0.122194938429242 no 486 0.101505812741865 455 17201110
SGTC_1770 st043884 66.3 µM 1.27136189136393 0.122524827337561 no 487 0.101799966712976 569 670149
SGTC_2173 5763948 167 µM 1.27113699059854 0.122569672417409 no 488 0.101839958861971 586 2867177
SGTC_2612 dictamnine 15.46 µM 1.26762157478356 0.123272141389095 no 489 0.102466561754324 564 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2775 cyproheptadine 69.59 µM 1.26758592562912 0.123279279410875 no 490 0.102472930339015 579 2913 A selective serotonin reuptake inhibitor.
SGTC_1851 st056236 18.9 µM 1.26626250342559 0.123544472892546 no 491 0.102709558334192 571 5393171
SGTC_1040 k898-0338 155 µM 1.26379609058055 0.124039769725492 no 492 0.103151612376549 612 20969351
SGTC_2782 7736369 71.43 µM 1.2637400848667 0.12405103271742 no 493 0.1031616662733 602 2950836 YOL077C BRX1
SGTC_539 4859-0462 2.54 µM 1.26334402787348 0.124130701920141 no 494 0.103232784974558 571 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2273 7815444 169.05 µM 1.26332749238306 0.124134028909958 no 495 0.103235754974255 534 2824616
SGTC_2304 7443016 91.4 µM 1.26113481642206 0.12457575456755 no 496 0.103630139275962 506 939854
SGTC_943 3253-1379 105 µM 1.25942222857427 0.124921527478452 no 497 0.10393893236207 576 668464
SGTC_2533 agelasine 13.65 µM 1.25877826187007 0.125051718188619 no 498 0.104055217096003 613 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2451 5856223 45.7 µM 1.25819342834954 0.125170036034896 no 499 0.104160905522223 564 2179896
SGTC_2732 terfenadine 20 µM 1.25621408561059 0.125571057377451 no 500 0.104519180589901 509 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1588 farnesol 29.9 µM 1.25600102788074 0.125614276958955 no 501 0.104557798707414 576 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1220 1838-0075 193 µM 1.25590234851411 0.125634297965226 no 502 0.104575688494902 586 5529645
SGTC_2921 7974240 10.71 µM 1.25589168846275 0.125636460910843 no 503 0.104577621210469 576 2979074 YDR527W RBA50
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.2553451895438 0.125747381437941 no 504 0.104676738607012 501 61125 An anti-inflammatory.
SGTC_1474 0330-0125 5.35 µM 1.24417657687141 0.128029200286585 no 505 0.106717291217666 590 X1474
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.24291919772791 0.128287880940282 no 506 0.106948805280345 646 6708784 An antioxidant flavonoid
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.24225139236312 0.128425416021351 no 507 0.107071911693651 564 75037 A free radical scavenger.
SGTC_1192 1488-0095 21.4 µM 1.24180822946137 0.128516742277974 no 508 0.107153662843256 560 915875
SGTC_1760 st045453 10.4495 µM 1.24036254152043 0.128814980519325 no 509 0.10742066470141 629 3323419 YIL048W NEO1
SGTC_2850 9015429 58.44 µM 1.24008006534488 0.12887330997534 no 510 0.107472890742427 549 6457570
SGTC_1071 trifluoperazine 6.31 µM 1.23931928750266 0.129030496657326 no 511 0.10761363932865 604 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2060 5238662 140 µM 1.2338062990925 0.130173524662345 no 512 0.108637545817806 568 790130
SGTC_2903 5923464 63.88 µM 1.23338860974433 0.130260410370066 no 513 0.108715406266177 573 2876576
SGTC_2497 7-hydroxyflavone 100 µM 1.23137643306676 0.130679535757049 no 514 0.109091053522154 527 5281894
SGTC_1211 1056-0033 32.3 µM 1.22930861810829 0.131111220679393 no 515 0.109478058651212 613 6741922
SGTC_2327 6189656 200 µM 1.22870700884663 0.13123699970112 no 516 0.109590838709957 573 5349088
SGTC_7 0192-1582 4.227 µM 1.22770887495823 0.13144586427945 no 517 0.10977813682352 716 252616
SGTC_1401 3807-4679 7.6 µM 1.22596506721919 0.131811315335239 no 518 0.110105910516883 564 3291456
SGTC_1174 0739-0097 51.1 µM 1.22412780724107 0.132197108922238 no 519 0.110452008785799 618 728447
SGTC_2950 9072895 21.46 µM 1.22293885994501 0.132447182276953 no 520 0.110676394869537 617 17332245
SGTC_1180 1193-0155 285 µM 1.22267715814327 0.132502270217041 no 521 0.110725828820223 561 2921347
SGTC_1116 jasmonic acid 1.58368 µM 1.21855260393283 0.133372569757559 no 522 0.111507023737654 608 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2642 cholecalciferol 100 µM 1.217051805525 0.133690218581651 no 523 0.111792252896862 572 9821465 A vitamin D precursor, similar to steriods.
SGTC_576 1073-0113 22.7 µM 1.21683975398334 0.133735141876965 no 524 0.111832595671781 782 5439563
SGTC_800 3448-7362 155 µM 1.21416810710573 0.134302021560543 no 525 0.112341768282072 859 15991913
SGTC_2275 7947463 200 µM 1.21052051037863 0.135078642955078 no 526 0.113039612688539 570 1225414
SGTC_2338 7999974 200 µM 1.20975734805243 0.135241519069854 no 527 0.113186008518907 662 315925
SGTC_1030 k029-0042 36.7 µM 1.2069561592619 0.135840509939796 no 528 0.113724514050777 668 6080581
SGTC_2682 pyrogallin 40.03 µM 1.20611021992729 0.136021757597269 no 529 0.113887497386398 664 822798 An ATP competetive kinase inhibitor.
SGTC_934 2950-0684 338 µM 1.20452772798369 0.136361260491717 no 530 0.114192835784221 648 1121253
SGTC_189 3970-0742 2.116 µM 1.20342120231235 0.136598995183079 no 531 0.114406683594066 603 2891807
SGTC_2236 dapsone 200 µM 1.20192259817873 0.136921418726249 no 532 0.114696759036362 638 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3084 9116877 49.47 µM 1.20044730508488 0.137239334576708 no 533 0.114982833122489 544 27241325
SGTC_3054 9094397 49.47 µM 1.19845318170482 0.137669855665166 no 534 0.115370319588031 650 2598354
SGTC_623 k072-0108 16.9 µM 1.19808398524508 0.137749664313345 no 535 0.115442161395534 622 5382803
SGTC_1752 st044819 83.042 µM 1.19692832372117 0.137999685992535 no 536 0.115667246641837 605 441209 YML126C ERG13
SGTC_469 w7 172 µM 1.19689957177246 0.138005910278584 no 537 0.115672850557134 571 45115570 A P450 inhibitor.
SGTC_2043 5101342 149 µM 1.19644134992479 0.138105133009926 no 538 0.115762186582407 616 678451
SGTC_830 4076-0286 57.8 µM 1.19100372014499 0.139286304024062 no 539 0.116826062227006 778 6866659
SGTC_1396 3511-0007 98.6 µM 1.19078216624662 0.139334575634934 no 540 0.116869555851324 562 X1396
SGTC_1882 5615643 20 µM 1.18936678709065 0.139643223517921 no 541 0.117147682227364 578 2253075
SGTC_1524 corynanthine 62.1 µM 1.1872174650333 0.140112808747323 no 542 0.117570926803829 602 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1814 st052110 31.539 µM 1.18427470431891 0.14075748309099 no 543 0.118152169367339 593 674163
SGTC_2226 7298446 200 µM 1.18416360489639 0.140781861147966 no 544 0.118174153027616 582 3283010
SGTC_181 1447-1644 8.07 µM 1.18390210358266 0.14083925253619 no 545 0.118225908691608 624 534600
SGTC_994 3910-0338 138 µM 1.1824734173041 0.14115308488461 no 546 0.118508953573199 659 3479481
SGTC_5 0352-0601 109.883 µM 1.18056971711914 0.141571997503211 no 547 0.118886849811757 582 762456
SGTC_1710 st031758 61.5 µM 1.18004164856066 0.141688349011118 no 548 0.118991825296028 608 5394341
SGTC_467 ro 31-8220 72.8 µM 1.17989046266942 0.14172167234114 no 549 0.119021891798232 666 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1754 st042065 16.137 µM 1.17857686719822 0.142011429235483 no 550 0.119283353748615 755 1126236 YIL048W NEO1
SGTC_137 0438-0332 85.389 µM 1.17851145066937 0.142025869488645 no 551 0.119296385036952 748 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.17728546472338 0.142296681412872 no 552 0.119540793231469 707 688761
SGTC_1800 st050079 29.0735 µM 1.17615744786067 0.142546161061344 no 553 0.119765982485009 785 3645560
SGTC_1281 0884-0031 11.8 µM 1.17578293204875 0.142629056817593 no 554 0.119840814256601 661 1548255
SGTC_2937 9044753 11.33 µM 1.17535169396035 0.142724547915049 no 555 0.119927020496434 677 6465530 YGL099W LSG1
SGTC_2841 9004761 38.96 µM 1.17530422820539 0.142735061122398 no 556 0.11993651176295 563 2991039
SGTC_2400 5203494 178.7 µM 1.17417361478571 0.142985635857966 no 557 0.120162746095975 596 6777674
SGTC_3112 9123419 49.47 µM 1.17378175920978 0.14307255105042 no 558 0.120241226032589 661 17015854
SGTC_3301 9125354 19.7965 µM 1.17373469583726 0.143082992302128 no 559 0.120250654205485 567 41905162
SGTC_2387 9077560 195.08 µM 1.171470616905 0.143585897999506 no 560 0.120704830917042 649 5303272
SGTC_21 0849-0113 22.993 µM 1.17138641267942 0.143604624740213 no 561 0.120721745636036 654 1560156
SGTC_2123 5259487 200 µM 1.16856286201985 0.144233527511849 no 562 0.121289899196077 681 2173474
SGTC_149 3970-0822 46.1 µM 1.16820025152345 0.144314427789169 no 563 0.12136299953354 789 3114250 YBL034C STU1
SGTC_2453 5731132 22.18 µM 1.16656392231869 0.144679881675809 no 564 0.121693260041521 698 1362040
SGTC_34 0469-0683 81.75 µM 1.16473052692907 0.145090087732988 no 565 0.122064044055965 644 3690923
SGTC_1993 st073995 70.8 µM 1.15577470775871 0.147105116743019 no 566 0.123886660478123 668 3098394
SGTC_3046 9092212 49.47 µM 1.15174781630647 0.148017240020709 no 567 0.12471235854577 650 25236637
SGTC_3077 9117319 49.47 µM 1.15121981667842 0.148137116281477 no 568 0.12482090731522 605 17154678
SGTC_3319 9138450 16.7555 µM 1.15021829425642 0.148364678901855 no 569 0.125026986575064 635 2029690
SGTC_1741 st038134 10.228 µM 1.14960734700562 0.148503611081799 no 570 0.125152815386925 705 1272587
SGTC_1853 st056710 91.2 µM 1.14806246791445 0.148855311617596 no 571 0.125471388373006 678 269167
SGTC_166 k072-0058 166.424 µM 1.14787511835904 0.148898000623844 no 572 0.125510060590362 663 5846229
SGTC_2575 plumbagin 510 nM 1.14627864569203 0.149262100767616 no 573 0.125839937869907 649 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1792 st045773 43.6 µM 1.14481116216409 0.14959730691208 no 574 0.126143695240116 659 2919270
SGTC_2870 9038528 12.99 µM 1.14461480018257 0.149642198467429 no 575 0.126184379340537 595 6463316
SGTC_1903 st060211 78.3 µM 1.14221295825417 0.15019202609024 no 576 0.126682755475605 709 688960
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.13818347346744 0.151117473233305 no 577 0.127521939052005 647 689007
SGTC_1304 1165-0502 251 µM 1.13809862849589 0.151137000178459 no 578 0.127539650384135 716 767425
SGTC_772 k072-0172 35.3 µM 1.13686044869197 0.151422156441774 no 579 0.127798314227161 615 5861980
SGTC_2856 9022925 19.48 µM 1.13558217393982 0.151716921770278 no 580 0.128065736418447 680 4944862
SGTC_2713 st079149 53.4 µM 1.13384276103381 0.15211863592661 no 581 0.128430255257971 708 3103253
SGTC_1672 st016598 6.51 µM 1.13335127098614 0.152232272506066 no 582 0.128533384405549 668 4665860 YNL267W PIK1
SGTC_679 0422-0091 41.4 µM 1.13249341415229 0.152430751131264 no 583 0.128713525820958 709 627384 YHR062C RPP1
SGTC_1313 1220-0047 237 µM 1.13126151255257 0.152716071135489 no 584 0.128972519189968 717 3528706
SGTC_1590 st077108 57.8 µM 1.12956035300952 0.153110657688393 no 585 0.129330762518267 668 5489485
SGTC_207 4185-0010 4.486 µM 1.12929140808913 0.153173101678544 no 586 0.129387462090113 773 3761753
SGTC_1205 4161-2785 76 µM 1.12926195193531 0.153179941872936 no 587 0.129393673149056 613 3498106
SGTC_2866 9034245 58.44 µM 1.12352024573043 0.154517124427158 no 588 0.130608303504863 651 6462273
SGTC_2227 7312221 64.1025 µM 1.12146227811558 0.154998276040801 no 589 0.131045569798096 678 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2330 7979373 200 µM 1.11535825709886 0.156431206103199 no 590 0.132348464952263 686 1863007
SGTC_2694 st077685 81.9 µM 1.11426006473569 0.156689931772961 no 591 0.1325838170185 672 2838096
SGTC_1392 3455-1037 33.9 µM 1.10928982905503 0.157864401080596 no 592 0.13365258568102 690 981132
SGTC_3015 9080845 49.47 µM 1.10514442879756 0.158848371569993 no 593 0.134548505902157 743 5296973
SGTC_2486 5283202 22.39 µM 1.10337092047493 0.15927056447596 no 594 0.134933059800369 663 1377751
SGTC_3127 9126946 49.47 µM 1.10335552440638 0.159274232804849 no 595 0.134936401462925 618 27243249
SGTC_1992 st073643 23.3 µM 1.102968773305 0.159366399821687 no 596 0.135020363053738 676 3161292
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.10210203362009 0.159573080167188 no 597 0.13520865769923 692 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2876 9059903 25.97 µM 1.09995154699307 0.160086636524794 no 598 0.135676616820725 760 6916095
SGTC_711 k292-0785 179 µM 1.09973765017262 0.160137776113256 no 599 0.135723222674372 702 4146315
SGTC_1149 3909-7961 23.3 µM 1.09698837921772 0.160796037173965 no 600 0.136323236035777 699 735261
SGTC_1545 lovastatin 49.4 µM 1.0946006486592 0.161369165657197 no 601 0.136845815649403 744 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2803 7707263 71.43 µM 1.09420418645097 0.161464457548198 no 602 0.136932717894333 681 2199229
SGTC_1879 gemcitabine 100 µM 1.08763136091819 0.163049617942915 no 603 0.138378940156844 727 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2297 7971671 152.32 µM 1.08761199485818 0.163054303328387 no 604 0.13838321660613 703 909016
SGTC_1899 st063254 59.6 µM 1.0875196651802 0.163076642587569 no 605 0.138403606255285 631 3093813
SGTC_3138 9097216 49.47 µM 1.08506367613214 0.163671601821805 no 606 0.138946726936998 705 25237486
SGTC_483 fpl-64176 144 µM 1.08499829614769 0.163687459245583 no 607 0.138961204955151 670 3423
SGTC_785 1270-0111 65.3 µM 1.08301824925996 0.164168177207456 no 608 0.139400161460641 707 6741994
SGTC_1763 st044482 94.5 µM 1.08236129695647 0.16432787490029 no 609 0.139546009363274 744 88505
SGTC_2102 5377816 72.7585 µM 1.07904992780465 0.165134364144366 no 610 0.140282735519087 763 1379702
SGTC_2133 5320837 200 µM 1.078381460778 0.165297480649728 no 611 0.140431778505868 678 2841355
SGTC_633 0437-0093 97.7 µM 1.07782201965414 0.165434073229003 no 612 0.14055659543291 710 2831118
SGTC_104 0074-0074 590.992 µM 1.07705474737751 0.16562152836715 no 613 0.140727904008014 592 3943124
SGTC_2174 5790901 200 µM 1.07665609693863 0.165718978339064 no 614 0.140816966440071 696 786020
SGTC_2834 9001755 58.44 µM 1.07252951034415 0.166729898574309 no 615 0.141741133248139 658 2989575
SGTC_369 0957-0393 4.5 µM 1.07157384132866 0.166964582117852 no 616 0.141955743952534 668 6997992
SGTC_1669 st015249 58.4 µM 1.06958020801656 0.167454843885837 no 617 0.14240415393174 745 722793
SGTC_1413 3910-0535 34.4 µM 1.06644307084754 0.168228185035812 no 618 0.143111700201901 768 2876951
SGTC_556 4058-0063 51.5 µM 1.06452642089855 0.168701790573849 no 619 0.143545145992759 792 6615692
SGTC_1556 plumbagin 1.48 µM 1.06000913759543 0.169821400583741 no 620 0.144570221148502 673 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2072 5231554 129 µM 1.05873488373722 0.17013808440297 no 621 0.144860268161497 776 789545
SGTC_1915 st067105 30.6 µM 1.05849541318115 0.170197641016287 no 622 0.144914820409477 733 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_909 3448-9333 149 µM 1.05680325045789 0.170618864536056 no 623 0.145300695274905 706 3344074
SGTC_2863 9028737 58.44 µM 1.05112022353805 0.172038397993173 no 624 0.146601688436994 734 6460917
SGTC_64 000l-0018 272.079 µM 1.04943471270931 0.17246085834988 no 625 0.146989044394945 831 6811119
SGTC_706 4262-0057 46.9 µM 1.04896080237475 0.172579759409246 no 626 0.1470980796899 720 883298
SGTC_2880 9042983 58.44 µM 1.04835528536639 0.172731755778259 no 627 0.147237473385798 737 6464714
SGTC_2268 7933382 153.85 µM 1.04629229768457 0.173250245586196 no 628 0.147713050224196 815 935025 YOR257W CDC31
SGTC_2342 7990637 118.86 µM 1.04534896162982 0.173487663679477 no 629 0.147930858163571 775 2033102 YER133W GLC7
SGTC_2261 9010538 184.68 µM 1.04252735450745 0.174199038870795 no 630 0.148583624974201 644 6457250
SGTC_375 3970-0961 9.27 µM 1.04106904953069 0.174567427986172 no 631 0.148921751375165 771 2898222
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.03813501164015 0.175310106537103 no 632 0.149603601706121 740 5355888
SGTC_2411 st077133 39.94 µM 1.03783007290529 0.175387408942273 no 633 0.149674586698174 815 1403142 YNL221C POP1
SGTC_3174 9107204 49.47 µM 1.03553169556571 0.17597074596001 no 634 0.150210336092466 737 3938802
SGTC_1947 st076332 61.6 µM 1.03324625998681 0.176552015003908 no 635 0.150744334637257 726 24208416
SGTC_1481 3346-2004 36 µM 1.03191127749589 0.176892110577331 no 636 0.151056841200151 788 2770522
SGTC_321 4534-3890 65.3 µM 1.03134736686765 0.177035894824442 no 637 0.151188976674464 774 699746
SGTC_2403 6032726 181.2 µM 1.03014437008727 0.177342878058853 no 638 0.151471119661177 735 2881040
SGTC_488 nitrendipine 139 µM 1.02765186795722 0.177979988830554 no 639 0.152056808214153 818 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3115 9123671 49.47 µM 1.02628704612225 0.178329462949736 no 640 0.152378150708033 814 3286988
SGTC_387 norethindrone acetate 66.7 µM 1.02608264426664 0.178381838968406 no 641 0.152426315183954 728 541197
SGTC_640 3381-0960 37.1 µM 1.0255185137911 0.1785264422827 no 642 0.152559297162299 822 1745025
SGTC_2462 5162487 171.77 µM 1.02534565269461 0.178570766464754 no 643 0.152600060958918 803 2259986
SGTC_3280 9140961 49.47 µM 1.02332133399029 0.179090347914835 no 644 0.153077969990095 741 4901226
SGTC_3038 9091290 49.47 µM 1.0223440212519 0.17934153465155 no 645 0.153309052498723 772 25236843
SGTC_3101 9120531 49.47 µM 1.02218762752908 0.179381751168132 no 646 0.153346052740637 785 24824904
SGTC_2746 daunorubicin 9.88 µM 1.021036765283 0.179677868804152 no 647 0.153618510188941 663 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1664 st014217 9.02 µM 1.01810281067547 0.180434165937676 no 648 0.154314549884171 862 3982782
SGTC_2567 aureobasidin a 60 nM 1.01686993331232 0.180752564678579 no 649 0.154607654104481 763 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1218 1348-1416 30.7 µM 1.01327860334904 0.181682055294924 no 650 0.155463552330462 765 6787668
SGTC_1112 tnp00069 1.16933 µM 1.01317009190574 0.181710186168477 no 651 0.155489461716883 836 145826
SGTC_1317 1273-0028 910 nM 1.01239822369577 0.181910366523109 no 652 0.155673843665772 800 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1213 1315-0166 115 µM 1.01110620381974 0.182245754250835 no 653 0.155982800714254 676 768401
SGTC_993 3909-8757 62.7 µM 1.0109179199026 0.182294661990455 no 654 0.156027858229644 726 4288324 YLR208W SEC13
SGTC_965 1291-5240 308 µM 1.00998119992193 0.182538101825291 no 655 0.15625214864335 813 2834598
SGTC_3192 9110362 49.47 µM 1.00948940917483 0.182665992299832 no 656 0.156369989152122 817 16649480
SGTC_3033 9090887 49.47 µM 1.00886381470279 0.182828759342597 no 657 0.156519975624066 803 19325384
SGTC_895 0964-0006 13.7 µM 1.00846996282412 0.182931278067485 no 658 0.156614450309237 790 6738897
SGTC_1161 k007-0610 110 µM 1.00695720055195 0.183325379980761 no 659 0.156977671036978 874 5843850
SGTC_143 4032-1194 15.74 µM 1.00507110319899 0.183817483315229 no 660 0.157431306673146 870 1806963
SGTC_685 1278-0033 54.9 µM 1.00379204498037 0.184151671266856 no 661 0.157739429777717 818 3590572
SGTC_3244 9134489 49.47 µM 1.00275866184137 0.184421946083528 no 662 0.157988659250467 776 16584271
SGTC_2711 st079103 59.1 µM 1.00151626064318 0.184747214744567 no 663 0.158288641395916 783 54693780
SGTC_3094 9117742 49.47 µM 1.00009940570553 0.185118591487619 no 664 0.158631201856384 850 17149698
SGTC_925 2064-1272 59.6 µM 0.998719790188914 0.185480652536071 no 665 0.158965225514334 763 6815817
SGTC_3351 9150312 21.596 µM 0.998309551996247 0.185588398609061 no 666 0.159064638589042 785 4904905
SGTC_3252 9135871 49.47 µM 0.994589716916962 0.186567158134854 no 667 0.159967925413882 803 17682838
SGTC_2132 5317594 122.667 µM 0.992291933263002 0.187173342832404 no 668 0.160527568612901 746 794577
SGTC_2071 5230951 39.92 µM 0.991622322441149 0.187350223672489 no 669 0.160690897956543 847 1799272
SGTC_2751 anetholtrithion 17.25 µM 0.991346036734053 0.187423235942553 no 670 0.16075832030406 789 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1302 1159-0335 255 µM 0.988711982291095 0.188120203612424 no 671 0.161402039302219 790 649284
SGTC_962 1254-0300 21.5 µM 0.988242301529306 0.18824464841519 no 672 0.161516997799525 807 7340576
SGTC_247 mechlorethamine 29.705 µM 0.987788878899901 0.188364833700507 no 673 0.161628027608061 765 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_973 1325-0077 65.9 µM 0.986231835843877 0.188777907478048 no 674 0.16200968012994 881 2835149
SGTC_526 4469-0568 170 µM 0.985421667630662 0.188993060676975 no 675 0.16220849541354 790 2901964
SGTC_903 1134-0042 114 µM 0.984267397231707 0.189299856539333 no 676 0.1624920276492 809 701009
SGTC_1529 apigenin 74 µM 0.979622816464902 0.190537445035822 no 677 0.163636169009097 825 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1387 3342-1166 1.8 µM 0.979517941459781 0.190565447111 no 678 0.163662064053555 753 3418228
SGTC_1634 st006576 41 µM 0.977483136034823 0.191109248797384 no 679 0.164165011299784 830 3915356
SGTC_908 3448-7491 47.7 µM 0.97366411299168 0.192132448255468 no 680 0.165111670741123 886 1203031
SGTC_2405 ticlatone 3.52 µM 0.967943164949036 0.193671471867631 no 681 0.166536377585035 833 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1845 st056753 3.01 µM 0.966220501477703 0.194136363539962 no 682 0.166966928129034 841 5375839
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.962694575998443 0.195090015014449 no 683 0.167850409747961 856 23665772 A membrane-active detergent.
SGTC_1067 clotrimazole 1.36 µM 0.961556825607794 0.195398347214709 no 684 0.168136133882552 858 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2343 7990716 14.84 µM 0.960222008670972 0.195760461886346 no 685 0.168471746194593 845 6456862
SGTC_3218 9131285 49.47 µM 0.95913751210692 0.196054968299164 no 686 0.168744737515656 914 17156417
SGTC_1680 diphenhydramine 100 µM 0.958272895455256 0.196289956443611 no 687 0.168962583836041 827 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_606 k015-0008 38.6 µM 0.954920784687056 0.197202616412064 no 688 0.16980887898642 931 1970475
SGTC_1448 4255-0083 152 µM 0.953672267517911 0.197543198156566 no 689 0.170124781098145 895 5399660
SGTC_2600 tangeritin 87.95 µM 0.95351821053224 0.197585247839541 no 690 0.170163786966192 787 68077 A bioactive flavone.
SGTC_2912 7964298 10.93 µM 0.953038085828421 0.197716332048025 no 691 0.170285387057667 889 2975850
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.947502361356498 0.199231495156013 no 692 0.171691426774182 894 5393153
SGTC_1705 st027868 56.3335 µM 0.947155032009464 0.199326793992887 no 693 0.171779892844584 869 292948
SGTC_1839 st053978 48 µM 0.945163595141986 0.199873726137814 no 694 0.172287681042437 857 3788398
SGTC_2168 5727979 200 µM 0.942844574154459 0.20051176280941 no 695 0.172880204210197 792 695210
SGTC_1187 1391-0724 117 µM 0.941675048025585 0.200834000215136 no 696 0.173179516840158 873 6997986
SGTC_2289 7946404 165.07 µM 0.941072382006461 0.201000172950177 no 697 0.173333883766533 902 1246120 YPR165W RHO1
SGTC_2933 9026794 32.47 µM 0.940823310939378 0.201068873244837 no 698 0.173397706427019 866 17586027
SGTC_2385 9074692 200 µM 0.937778755542628 0.20190977874509 no 699 0.174179060467791 868 17046906
SGTC_618 k072-0232 33.2 µM 0.934255216477171 0.20288560311101 no 700 0.175086129614096 840 5872756 YGL099W LSG1
SGTC_370 0180-0345 38.7 µM 0.93161852545522 0.203617659260104 no 701 0.175766852864066 795 3989527
SGTC_1139 k015-0024 46.9 µM 0.931220983828408 0.203728169998284 no 702 0.175869632756645 892 2766652
SGTC_3320 9137005 35.139 µM 0.928573994987587 0.204464905289501 no 703 0.176554951975973 831 4908713
SGTC_898 1000-0849 28.3 µM 0.928155646502228 0.204581488987552 no 704 0.176663418937853 910 6751807
SGTC_31 0508-1974 57.237 µM 0.928010251366289 0.204622016388217 no 705 0.176701126007407 860 6810525
SGTC_2601 securinine 100 µM 0.926569030068497 0.205024000299721 no 706 0.177075170431875 831 442872 A GABA receptor antagonist.
SGTC_1649 st011737 51.3 µM 0.923557797976056 0.20586540342529 no 707 0.177858297416071 871 1761035
SGTC_1786 berberine 21.6 µM 0.921924967005745 0.206322506900828 no 708 0.178283857522924 830 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1280 0880-0253 10.1 µM 0.920812367789514 0.206634318185113 no 709 0.178574198362453 887 6836607
SGTC_2307 7538926 6.34 µM 0.920671694697408 0.206673762359615 no 710 0.178610929220681 887 96582
SGTC_1829 berberine 14.4 µM 0.919708956607182 0.206943829935354 no 711 0.178862435446808 881 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_745 0469-0705 296 µM 0.919618601143933 0.20696918719261 no 712 0.178886051394099 981 3486736
SGTC_2580 diallyl disulphide 81.36 µM 0.919549867157494 0.206988477853796 no 713 0.178904017512441 828 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2714 st079313 56.9 µM 0.919029259070596 0.207134624601689 no 714 0.179040134176348 875 2939799
SGTC_2301 7769476 200 µM 0.918761582344208 0.207209791412845 no 715 0.179110145505699 854 977820
SGTC_1939 st074455 53.6 µM 0.918038110398428 0.207413031656323 no 716 0.179299457060143 901 1644229
SGTC_2187 6125751 200 µM 0.916729386514814 0.207780982154698 no 717 0.179642231558339 895 874498
SGTC_2630 antimycin a 100 µM 0.915639722995225 0.208087637304619 no 718 0.179927944789518 933 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3322 9139058 2.11 µM 0.915235068759201 0.208201583841949 no 719 0.180034119040016 895 4908926 YPR165W RHO1
SGTC_2897 9048598 12.99 µM 0.911162470350477 0.209350434806675 no 720 0.181104887503721 862 6467404
SGTC_2882 9058044 58.44 µM 0.910135744775931 0.209640654504893 no 721 0.181375462828417 886 18076804
SGTC_521 r062-0005 13.8 µM 0.909679563596298 0.209769676977793 no 722 0.181495762458748 873 2832033
SGTC_265 mycophenolic acid 32.932 µM 0.909305694017169 0.209875453926234 no 723 0.181594392911223 944 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1811 st050069 61.5 µM 0.908011462372905 0.210241866089825 no 724 0.181936082852679 912 3877702
SGTC_1567 st069303 68.4 µM 0.907004730402336 0.210527143315195 no 725 0.182202147862797 898 5581319
SGTC_379 3970-0972 5.9 µM 0.90634150138722 0.21071520631554 no 726 0.182377562714034 887 2898042 YBL034C STU1
SGTC_509 pifithrin 175 µM 0.903017571132641 0.211659212356007 no 727 0.183258284713419 969 4817 A p53 inhibitor.
SGTC_2975 9084847 53.72 µM 0.902095712245621 0.211921460820212 no 728 0.183503013199366 902 27211724
SGTC_1393 3470-5649 58.2 µM 0.900640364189399 0.212335861816355 no 729 0.183889782984273 817 4108395
SGTC_599 1935-0052 86.5 µM 0.898770122287578 0.212869095856311 no 730 0.184387558765639 943 9557311
SGTC_3131 9127911 49.47 µM 0.897771507959105 0.213154135570994 no 731 0.184653688756443 856 45595681
SGTC_875 0709-0210 25.7 µM 0.891847139768477 0.214849730937879 no 732 0.186237435440805 991 6251364
SGTC_775 4577-0580 57.3 µM 0.891556395982735 0.214933145038487 no 733 0.186315375328784 927 2006902
SGTC_3076 9116187 49.47 µM 0.889384615593261 0.215556821378713 no 734 0.186898205085601 886 27241210
SGTC_1662 st014054 52 µM 0.886830006197191 0.216291777432022 no 735 0.187585215000452 908 2838777
SGTC_1979 st071809 45.3 µM 0.886629499966065 0.216349524011112 no 736 0.187639203009278 938 4976333
SGTC_2147 5545932 89.7195 µM 0.884982237561346 0.216824279735969 no 737 0.188083105740323 908 797404
SGTC_1821 st053465 65.6 µM 0.884658378174547 0.216917689703645 no 738 0.188170455248621 882 675086
SGTC_1342 1486-1464 234 µM 0.88454532892893 0.216950301696291 no 739 0.188200952140498 930 3253938
SGTC_2994 9053520 71.4286 µM 0.883284428936044 0.217314233092873 no 740 0.188541307320954 936 4647384
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.881885670775304 0.217718366432541 no 741 0.188919318344336 966 165521
SGTC_831 k061-1017 217 µM 0.880340176314128 0.218165399058181 no 742 0.189337527061074 1047 1240153
SGTC_1686 st019653 115.5 µM 0.880266025787252 0.218186860309328 no 743 0.189357606409914 958 97252
SGTC_3001 9076041 71.4286 µM 0.879270296970397 0.21847517011524 no 744 0.189627368493018 915 16004211
SGTC_2200 6600604 21.907 µM 0.879225887014836 0.218488033971589 no 745 0.189639405508574 942 2904777
SGTC_828 2074-0507 139 µM 0.878043175537511 0.218830780454562 no 746 0.189960144306187 949 X828
SGTC_1661 st013063 9.66 µM 0.877760043915981 0.218912877078572 no 747 0.190036976038127 999 721395
SGTC_982 1491-0518 27.5 µM 0.876850150403078 0.219176829021464 no 748 0.190284017680735 880 3091256
SGTC_47 0149-0135 24.25 µM 0.876219988458437 0.219359740533852 no 749 0.190455226065738 961 5239155
SGTC_380 3970-0968 6 µM 0.875206576806751 0.219654078418952 no 750 0.190730757679009 902 2891601
SGTC_1356 1502-0781 85.8 µM 0.874364721292859 0.219898761454922 no 751 0.19095983163304 906 567702
SGTC_1236 0330-0013 258 µM 0.873168875840693 0.220246599477617 no 752 0.19128551835675 918 4617066
SGTC_1877 wortmannin 25 µM 0.872220694070978 0.220522623164335 no 753 0.191543996099347 975 312145 A covalent inhibitor of PI 3-kinase.
SGTC_391 gliotoxin 8.33 µM 0.871922607388086 0.220609439640584 no 754 0.191625299781812 984 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1596 piperlongumine 63 µM 0.87177738730552 0.220651741463029 no 755 0.19166491647839 991 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.871615043811806 0.220699036742399 no 756 0.191709210456898 913 17037758
SGTC_54 0159-0055 9 µM 0.87089817242396 0.220907951193412 no 757 0.191904877385955 944 3319099
SGTC_460 trequinsin 123 µM 0.870824315087081 0.220929481520071 no 758 0.191925043368779 995 5537 A vasodilator.
SGTC_1259 0671-0132 43 µM 0.869885778461809 0.221203181145905 no 759 0.192181414053607 892 X1259
SGTC_1727 st034309 9.9045 µM 0.869602376657827 0.22128586597291 no 760 0.192258869259323 1008 870305
SGTC_665 3914-0008 307 µM 0.868406888783566 0.221634853977645 no 761 0.192585812496887 927 1069549
SGTC_354 2783-3500 4.88 µM 0.867122811674693 0.222010053143845 no 762 0.192937361484292 906 6740761
SGTC_1702 st027038 51 µM 0.865790257474029 0.222399800155439 no 763 0.193302596423775 962 5521182
SGTC_2819 7996655 46.38 µM 0.864895525317979 0.222661711308248 no 764 0.193548066906099 851 6456960
SGTC_428 3448-4153 16.5 µM 0.863648993906164 0.223026896101624 no 765 0.193890370581794 866 3834874
SGTC_1426 4048-4480 71.7 µM 0.863420879116483 0.223093761686839 no 766 0.193953051943296 972 14224343
SGTC_720 r052-1644 49.9 µM 0.862266807010738 0.223432221134048 no 767 0.1942703569991 858 1422863 YOR257W CDC31
SGTC_212 3807-4682 38.772 µM 0.862048141754102 0.223496382892346 no 768 0.194330513274305 1091 3125501 YBL034C STU1
SGTC_1719 st032227 49.2 µM 0.861867543661076 0.223549382711547 no 769 0.194380205569109 960 3125804
SGTC_3106 9121286 49.47 µM 0.861434527509358 0.223676488348147 no 770 0.19449938321951 916 15943471
SGTC_2376 9072922 81.32 µM 0.859300905253966 0.224303382075789 no 771 0.195087262438872 968 17087968
SGTC_725 1497-0963 19 µM 0.857723911101597 0.224767369560745 no 772 0.195522466723608 994 3549977
SGTC_2131 toluylene red 5.2905 µM 0.857128487531959 0.224942698133529 no 773 0.195686939432536 926 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1515 3460-0031 42.1 µM 0.856430586997715 0.225148300743042 no 774 0.195879826035184 908 2876596
SGTC_2474 5321570 43.32 µM 0.856058110646678 0.225258076427948 no 775 0.195982818705268 962 2841384
SGTC_2592 piperlongumine 83.33 µM 0.854009202066241 0.225862469478038 no 776 0.196549945370118 904 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3141 9094609 49.47 µM 0.853704183662306 0.225952523056874 no 777 0.196634457743596 884 25236309 YDL196W YDL196W
SGTC_392 N-ethylmaleimide 8.33 µM 0.852568512095881 0.226287996968587 no 778 0.196949315220306 927 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3148 9097893 49.47 µM 0.852210822848357 0.226393715516458 no 779 0.19704854537814 948 17174100
SGTC_756 0508-1999 28.3 µM 0.852084136256921 0.226431165663068 no 780 0.197083698029864 914 6753853
SGTC_138 0850-0259 40.9225 µM 0.850628133186014 0.226861829514104 no 781 0.197487978207388 1016 6813004
SGTC_2053 5265679 138 µM 0.849460280046864 0.227207596622444 no 782 0.197812611525328 988 764595
SGTC_836 0330-0104 1.35 µM 0.849058537813053 0.227326609356623 no 783 0.197924360087464 979 46494820
SGTC_1057 3448-5381 134 µM 0.847709297616802 0.227726567304648 no 784 0.198299943545535 995 5497911
SGTC_2388 9080168 200 µM 0.847362946349662 0.227829300748984 no 785 0.198396425521118 902 15943073
SGTC_1945 st075991 56.6 µM 0.840000450434825 0.230019297239863 no 786 0.200454066983858 895 1084980
SGTC_2587 piperic acid 92.2 µM 0.839628697980346 0.230130187679534 no 787 0.200558301715761 909 5370536
SGTC_1452 4194-0072 190 µM 0.836179152809431 0.231160581382183 no 788 0.201527062285985 1044 1343545
SGTC_446 go6976 132 µM 0.835440920757973 0.231381428349601 no 789 0.201734748937187 976 3501 A protein kinase C inhibitor.
SGTC_1801 st050089 28.441 µM 0.834828371787988 0.231564765684654 no 790 0.201907174463819 1036 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3161 9100388 49.47 µM 0.834633498313615 0.231623108743703 no 791 0.201962047610533 1028 25236368
SGTC_2354 9060492 162 µM 0.834099516296807 0.231783019290332 no 792 0.202112453849166 1033 6471895
SGTC_2674 ligustilide 100 µM 0.833902237356132 0.2318421135827 no 793 0.20216803818349 963 5319022 A signalling regulator.
SGTC_188 3229-0966 278.469 µM 0.833323563967228 0.232015501797419 no 794 0.202331135075174 1108 5722370
SGTC_850 0388-0143 75.9 µM 0.833215076610167 0.232048015956363 no 795 0.20236172058091 955 67273
SGTC_2427 5545055 42.75 µM 0.832056056016256 0.232395538019485 no 796 0.202688652211527 1037 5372858
SGTC_1531 st059297 52.4 µM 0.830919154079937 0.232736709072966 no 797 0.20300965116849 1004 7566702
SGTC_2686 alizarin 95.37 µM 0.828965269808343 0.233323696740706 no 798 0.203562029936086 963 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1904 st060225 78 µM 0.828843096446611 0.233360427441236 no 799 0.203596599077867 970 66595
SGTC_2484 5809818 12.04 µM 0.828366150319327 0.233503849186024 no 800 0.20373158523004 961 2870548
SGTC_298 1391-0729 10 µM 0.8275919853873 0.233736751192708 no 801 0.203950804340035 990 3237558
SGTC_926 2268-1401 59.4 µM 0.826357765258826 0.234108323669226 no 802 0.204300587108128 1049 2931578
SGTC_3248 9135562 49.47 µM 0.825805683566217 0.234274638388521 no 803 0.204457164747352 1008 17650701
SGTC_3185 9108267 49.47 µM 0.825012172733749 0.234513798198524 no 804 0.204682339932627 1022 4910486
SGTC_2983 9022671 12.99 µM 0.822215822421104 0.235357678498531 no 805 0.205477037591997 983 6405161
SGTC_256 clotrimazole 625 nM 0.821152691913304 0.235678948372523 no 806 0.205779649782425 982 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1734 st037168 69.4 µM 0.820676805506099 0.235822835915731 no 807 0.205915192945574 954 708907
SGTC_2314 7727897 200 µM 0.82053138273914 0.23586681515324 no 808 0.205956623186083 1018 900724
SGTC_2225 6654152 15.4 µM 0.82002868484924 0.23601887754545 no 809 0.206099877457001 967 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1418 3966-3099 2.4 µM 0.819976135138625 0.23603477656214 no 810 0.206114856005553 1025 740335
SGTC_202 3594-0513 34.79 µM 0.819682966489796 0.236123486133365 no 811 0.206198431408705 1008 708429
SGTC_2000 st075254 36.4 µM 0.819335118159486 0.236228764987601 no 812 0.206297620742099 976 17234175
SGTC_3212 9128307 49.47 µM 0.816859725351031 0.236978706874328 no 813 0.207004297995076 879 27243542
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.811756754491708 0.238528817581828 no 814 0.20846561054407 962 15053
SGTC_3099 9120367 49.47 µM 0.810986541848024 0.238763263398252 no 815 0.208686699717535 1030 24824940
SGTC_3079 9117512 49.47 µM 0.81000225575196 0.23906305465094 no 816 0.208969439639241 1077 7185044
SGTC_1247 0448-0043 5.84 µM 0.8086630055788 0.239471290158735 no 817 0.209354506487687 1033 3089013 YGL099W LSG1
SGTC_3263 9137018 49.47 µM 0.807672813278714 0.239773369070965 no 818 0.209639479058959 1005 43844957
SGTC_1324 1418-0026 34.4 µM 0.807403735515426 0.23985549279192 no 819 0.209716957743017 1022 1372513
SGTC_2472 5377652 49.4 µM 0.806089918813204 0.240256695715431 no 820 0.210095501969739 1012 1610903
SGTC_237 nikkomycin 200 µM 0.805612301220692 0.240402637368306 no 821 0.210233215251354 1039 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2926 9010726 65.15 µM 0.805270911902412 0.24050698246081 no 822 0.210331681801313 1026 2994293
SGTC_8 0354-0001 70 µM 0.804608604157479 0.240709486066494 no 823 0.210522787710503 1100 4993152
SGTC_3229 9132204 49.47 µM 0.803618035055746 0.241012530180855 no 824 0.210808802055005 1035 17682924
SGTC_1408 3909-7976 48.8 µM 0.802641200179752 0.241311575656769 no 825 0.211091073869482 1068 24152374
SGTC_1333 1482-0047 286 µM 0.801715679457667 0.24159509787057 no 826 0.21135872191417 1060 3811116
SGTC_764 1951-2361 146 µM 0.801309424096978 0.241719606442901 no 827 0.211476268203542 984 5438930
SGTC_1983 st071813 46.9 µM 0.80103550423897 0.241803576670763 no 828 0.211555546022703 1005 11838595
SGTC_945 3381-0768 11.3 µM 0.797745651773396 0.242813317733181 no 829 0.212509052916847 1080 1126236 YIL048W NEO1
SGTC_2923 7992654 58.14 µM 0.796781199057316 0.243109765251498 no 830 0.212789058004945 1019 2985126
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.796007295290022 0.243347784471247 no 831 0.213013897567692 1054 688798
SGTC_1901 st060216 58.6 µM 0.795737778034753 0.243430705840676 no 832 0.213092232006173 1073 688792
SGTC_131 0141-0277 33.849 µM 0.795683662850007 0.243447357098025 no 833 0.213107962459205 1014 1547771
SGTC_1042 0350-0096 82 µM 0.794841112389936 0.243706689465077 no 834 0.213352966297525 1016 3122515
SGTC_132 0417-1715 25.805 µM 0.794750028574519 0.243734733489617 no 835 0.213379462239769 1076 6769098
SGTC_3201 9113999 49.47 µM 0.794192876424717 0.243906314377674 no 836 0.213541577469928 995 16649224
SGTC_6 0844-0013 19.835 µM 0.794091228117862 0.243937625075796 no 837 0.213571161939599 1199 1584900
SGTC_1950 st077106 7.18 µM 0.793914030419113 0.243992212415937 no 838 0.213622740569114 1002 13831864
SGTC_197 4544-0043 41.561 µM 0.793560062600646 0.244101275103322 no 839 0.213725795094009 1088 896523
SGTC_1381 2324-0066 62.1 µM 0.792497634142061 0.244428782751197 no 840 0.214035285358988 1002 10885928
SGTC_1547 harmine 94.2 µM 0.79168564256498 0.244679249452742 no 841 0.214271997981427 1130 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1815 st051655 58.2 µM 0.791468994733374 0.244746099931869 no 842 0.214335181107928 1033 5984156
SGTC_1506 4226-2149 212 µM 0.790825364443475 0.244944761305482 no 843 0.214522953210606 1084 991114
SGTC_605 1315-0399 119 µM 0.790557541149445 0.245027452554746 no 844 0.214601115898074 1071 24020461
SGTC_1279 0874-0590 65.2 µM 0.788334836700811 0.24571429836344 no 845 0.215250437871187 1057 3523074
SGTC_432 NS 1619 61.3 µM 0.788181074416098 0.24576185119582 no 846 0.215295398804685 979 4552 A K+/calcium channel activator.
SGTC_3314 9135860 59.4275 µM 0.784623810608373 0.24686335578295 no 847 0.216337082686394 1085 25252478
SGTC_3074 9116018 49.47 µM 0.784533050253673 0.24689149420157 no 848 0.216363698415956 1063 17027303
SGTC_1523 st012844 44.7 µM 0.783138333159045 0.247324113916727 no 849 0.216772941416872 1039 4274103
SGTC_332 4112-0506 40.9 µM 0.78182130756948 0.247733006644904 no 850 0.217159798463365 1043 2790355
SGTC_740 k014-0057 261 µM 0.779632834224422 0.248413252448489 no 851 0.217803511792734 1085 4012779
SGTC_761 k216-0224 480 µM 0.779134658001342 0.248568240149381 no 852 0.217950198024377 1116 1340404
SGTC_10 0279-0212 42.575 µM 0.775501192401062 0.24970020468253 no 853 0.219021780574186 1134 39851 YBR002C RER2
SGTC_1893 st059353 36.1 µM 0.774844665998138 0.249905029580182 no 854 0.219215726198975 1041 3112488
SGTC_1111 tnp00062 510.699 nM 0.774586325269374 0.249985651868039 no 855 0.219292070148644 1120 676306
SGTC_2627 acetyl isogambogic acid 100 µM 0.774496437314219 0.250013707098434 no 856 0.219318637106108 1054 6857789 A caspase activator and apoptosis inducer.
SGTC_549 1661-1316 519 µM 0.771150420701726 0.251059231020315 no 857 0.220308888752519 1114 2857282
SGTC_2100 5377183 190 µM 0.770425961313743 0.251285905824029 no 858 0.220523629171514 1120 2844202
SGTC_3340 9146634 11.102 µM 0.769553325974719 0.251559086739933 no 859 0.220782450296667 1083 4907387
SGTC_2122 5258151 111.688 µM 0.769041750500199 0.251719309786153 no 860 0.220934262953669 1059 2173356
SGTC_887 0885-0007 9.62 µM 0.766800507123181 0.252421891471151 no 861 0.221600067411626 1092 5719458
SGTC_1666 st014829 29 µM 0.765992255500974 0.252675514332244 no 862 0.221840455144309 1118 3858230
SGTC_2035 5154463 94.595 µM 0.765032645977652 0.252976806257568 no 863 0.222126052579491 1086 2769623
SGTC_2830 7992007 71.43 µM 0.762576102180246 0.253748956405428 no 864 0.222858120635078 1020 1952075
SGTC_2063 5246145 200 µM 0.761163813887314 0.254193431781696 no 865 0.223279614442735 1120 711240
SGTC_519 k048-0011 62.8 µM 0.761104109365812 0.254212230979596 no 866 0.223297443093691 1071 6836379
SGTC_1519 esterone 74 µM 0.761077740648203 0.254220533945351 no 867 0.223305317439719 1095 698 A steroid.
SGTC_1520 flindersine 88 µM 0.760922281942538 0.254269487578307 no 868 0.223351744435501 1138 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_861 0443-0273 110 µM 0.760687308830164 0.254343489517177 no 869 0.22342192845128 1097 6149169
SGTC_1138 3761-0006 1.03 µM 0.760090627637321 0.254531457760473 no 870 0.223600207270424 1091 12061087
SGTC_1819 st053448 58.6 µM 0.760049719556997 0.254544347408102 no 871 0.223612432914741 1077 2857616
SGTC_1371 2421-0008 32.7 µM 0.759773949715063 0.254631248114044 no 872 0.223694858433202 1049 2827552
SGTC_2875 9039966 71.43 µM 0.759073547069928 0.254852029112152 no 873 0.223904281117038 1126 6463691
SGTC_1626 st003712 1.76 µM 0.758612630012209 0.25499737408339 no 874 0.224042157589217 1035 24207035
SGTC_636 0kpi-0074 126 µM 0.758435962974569 0.255053095526936 no 875 0.224095017685455 1062 616434
SGTC_1612 st002233 45.4 µM 0.758189540796741 0.255130828639386 no 876 0.224168760870583 1142 1035021
SGTC_1296 1068-0102 11.9 µM 0.756320987985944 0.255720660776516 no 877 0.224728383762323 1075 767053
SGTC_2171 5739187 198.077 µM 0.75596875609068 0.255831926894487 no 878 0.22483396426103 1080 2262761
SGTC_1962 st076595 64.5 µM 0.755612282004196 0.255944558795348 no 879 0.224940844971669 1125 279619
SGTC_2536 dehydroabietamide 32.04 µM 0.753402508460927 0.256643337901048 no 880 0.225604037935659 1127 3983547
SGTC_883 0850-0245 24.6 µM 0.753362656663005 0.256655949031557 no 881 0.225616008328411 1107 6823229 YPR165W RHO1
SGTC_1119 parthenolide 318.541 nM 0.751260739855156 0.257321559199476 no 882 0.226247875950991 1162 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2907 7721985 69.9 µM 0.750872245045481 0.257444681301559 no 883 0.226364772674019 1100 3267881
SGTC_3012 9080433 71.4286 µM 0.748419398646107 0.258222745508529 no 884 0.227103612647429 1140 17688859
SGTC_2096 5468907 200 µM 0.747605459991795 0.258481203018393 no 885 0.227349085204543 1129 759785
SGTC_296 1222-0039 74.9 µM 0.747168554784656 0.25861999283851 no 886 0.227480911359694 1092 5984176
SGTC_907 3448-6986 75.5 µM 0.746426487480199 0.258855810596458 no 887 0.227704911826035 1144 590582
SGTC_1780 st038448 24.544 µM 0.746360812620618 0.258876686430499 no 888 0.227724742420572 1101 728868 YDL195W SEC31
SGTC_1300 1094-0077 113 µM 0.745964458840525 0.259002692485469 no 889 0.227844442505361 1063 5532636
SGTC_1640 st009078 66.4 µM 0.745153214883029 0.259260696428017 no 890 0.228089551082559 1077 690618
SGTC_2656 pseudo-anisatin 100 µM 0.744575368418626 0.259444552773109 no 891 0.228264231523864 1121 6708809 A neurotoxin.
SGTC_1234 0326-0494 15.5 µM 0.743625485532066 0.259746928113016 no 892 0.228551540275446 1134 1547813
SGTC_591 4299-0174 154 µM 0.743378542873109 0.25982556691632 no 893 0.228626265671088 1088 5509088
SGTC_2618 avocadyne 43.43 µM 0.74251731776911 0.260099919840798 no 894 0.228886981635153 1090 3015189
SGTC_1835 st008666 49.2 µM 0.740829862629135 0.260637910279543 no 895 0.229398303055393 1025 690455
SGTC_3209 9113616 49.47 µM 0.740747667114302 0.260664130279887 no 896 0.22942322573474 1144 16649353
SGTC_2964 9083345 53.42 µM 0.740279092203713 0.260813629498299 no 897 0.229565332325244 1106 17741579
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.739900581971357 0.26093442570512 no 898 0.229680160638783 1132 364106
SGTC_2477 5967686 25.23 µM 0.739709591800665 0.260995388446529 no 899 0.229738113366983 1130 776118
SGTC_3302 9125395 16.351 µM 0.738894838116964 0.261255534418942 no 900 0.229985428511154 1086 17599668
SGTC_404 fumagillin 50 µM 0.738227561377358 0.261468691077085 no 901 0.230188088571806 1109 12015870 A methionine aminopeptidase binder.
SGTC_1494 4358-1428 177 µM 0.737361911567451 0.261745349560487 no 902 0.23045114573687 1174 1564571
SGTC_735 3076-0345 636 µM 0.736758716936381 0.261938217084156 no 903 0.230634546261859 1162 2888990
SGTC_1721 st082152 9.2685 µM 0.734605667431113 0.262627234288479 no 904 0.231289842709429 1122 5296051
SGTC_999 SEC7.066 22.7 µM 0.733394830554073 0.263015132390972 no 905 0.231658825604926 1157 740511 YDR170C SEC7
SGTC_1781 st038725 66.3 µM 0.732590621817859 0.263272926718815 no 906 0.231904076351762 1151 4270275 YIL048W NEO1
SGTC_77 0828-0286 12.516 µM 0.731851002327348 0.263510130410092 no 907 0.232129757611658 1134 745345
SGTC_1228 0124-0032 52.5 µM 0.73027054191359 0.264017365862347 no 908 0.232612415441977 1179 X1228
SGTC_2717 st081029 62.2815 µM 0.726299333476621 0.265294083824646 no 909 0.233827643940267 1120 5292846
SGTC_2282 7944268 200 µM 0.725614705654169 0.265514503573158 no 910 0.234037501712493 1162 2970414
SGTC_1164 k060-0068 93.7 µM 0.724901621305596 0.265744183796004 no 911 0.234256193083108 1191 5963676
SGTC_177 1327-0068 8.361 µM 0.723947179310912 0.266051761429551 no 912 0.23454908186818 1152 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2517 totarol 10 µM 0.722709386286054 0.266450919882358 no 913 0.234929223838171 1121 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_272 doxorubicin 8.13 µM 0.721296706872904 0.266906844863763 no 914 0.235363491336778 1173 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2108 5365811 200 µM 0.721188018423194 0.266941939050115 no 915 0.235396921270699 1170 780283
SGTC_693 4161-2696 114 µM 0.718703928183388 0.267744656615951 no 916 0.236161681234308 1144 805759
SGTC_2128 5255449 168.493 µM 0.717075543600967 0.268271517667849 no 917 0.236663742585349 1184 736008
SGTC_1943 st076331 65.2 µM 0.717017218169563 0.268290398432337 no 918 0.236681736289458 1233 24208415
SGTC_472 calcifediol 10 µM 0.716912569076781 0.268324276494706 no 919 0.236714022974487 1133 5283731 A vitamin D metabolite.
SGTC_626 0214-0009 33 µM 0.716706494693043 0.268390995267739 no 920 0.236777608808071 1171 3437874
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.713487983963999 0.269434103806822 no 921 0.237771923004887 1177 5282362
SGTC_2723 salbutamol 83.58 µM 0.713434170811527 0.269451561727415 no 922 0.237788567274991 1128 9884233 β2-adrenoceptor agonist
SGTC_1697 st025554 27.742 µM 0.712530322373148 0.269744870562026 no 923 0.238068220764063 1167 1269519
SGTC_788 1182-0090 188 µM 0.711864288833882 0.269961108104053 no 924 0.238274408890085 1223 5715185
SGTC_1123 mangostin 811.285 nM 0.710822129585482 0.270299634350109 no 925 0.238597232767708 1124 5281650 An antioxidant.
SGTC_2684 capsaicin 100 µM 0.710746114141148 0.270324334869968 no 926 0.238620789012743 1174 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1621 st003705 32.4 µM 0.709521674901408 0.27072236055293 no 927 0.239000402887268 1211 24207032
SGTC_3025 9087895 49.47 µM 0.707190060988336 0.271481101222507 no 928 0.23972418710738 1195 17173641
SGTC_2337 9009472 200 µM 0.704594517542867 0.272326972386997 no 929 0.240531305655964 1195 5742383
SGTC_2425 5628681 7.85 µM 0.700256330211788 0.273743676974302 no 930 0.241883619287494 1207 5714958
SGTC_1932 st074806 40.9 µM 0.700087002136672 0.27379904760162 no 931 0.241936486290951 1294 17251235
SGTC_198 3454-2873 16.191 µM 0.699418977050381 0.274017547185547 no 932 0.242145115813836 1180 710957
SGTC_1345 1488-0192 31.4 µM 0.698597379343099 0.274286395856011 no 933 0.242401840975776 1209 658348
SGTC_1762 st045503 25.4615 µM 0.69659249345639 0.274942994158375 no 934 0.24302892745526 1221 4645554
SGTC_1193 1488-0126 41.5 µM 0.696201666873767 0.275071079653569 no 935 0.24315127196993 1224 1384710
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.694285778806177 0.275699397999633 no 936 0.243751503826201 1169 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1608 st001473 40.5 µM 0.693558200954826 0.275938192933703 no 937 0.243979657314517 1159 7292267
SGTC_2665 lovastatin 100 µM 0.69185538353114 0.276497463502615 no 938 0.244514075964331 1199 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1667 st014849 34.6 µM 0.69098257295051 0.276784343270213 no 939 0.244788246390285 1237 5348460
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.689888874924071 0.277144031136303 no 940 0.245132036255616 1134 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1173 0443-0020 122 µM 0.687572611085417 0.277906542267449 no 941 0.245860980380838 1205 5331295
SGTC_3207 9114163 49.47 µM 0.687515574969863 0.277925331394982 no 942 0.245878944703204 1253 849233
SGTC_3348 9149464 3.537 µM 0.68575239454123 0.278506472901657 no 943 0.246434630378843 1221 1951442
SGTC_1562 morin hydrate 59.1 µM 0.685137501556947 0.278709279796174 no 944 0.246628578811641 1233 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1238 0333-0287 48.8 µM 0.682133354812347 0.279701154016545 no 945 0.247577315623996 1217 7226
SGTC_3044 9093193 49.47 µM 0.682021785752356 0.279738023555299 no 946 0.247612587655169 1182 25236277
SGTC_3090 9117696 49.47 µM 0.681708760545933 0.279841479651361 no 947 0.247711563423738 1189 7923821
SGTC_2246 7293507 91.5585 µM 0.680150500535867 0.280356766850648 no 948 0.248204585489531 1246 887656
SGTC_505 gw-5074 63.9 µM 0.679907929210228 0.280437021922974 no 949 0.248281380325078 1220 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1334 1486-0610 236 µM 0.67875699409826 0.280817961964021 no 950 0.248645923564879 1212 3742339
SGTC_1005 4092-0690 4.4 µM 0.678568315951263 0.280880435098891 no 951 0.248705712021177 1208 1529343
SGTC_3000 9075062 71.4286 µM 0.677681473015189 0.281174167229267 no 952 0.248986837933707 1207 17057871
SGTC_1397 3532-0190 20.1 µM 0.676870516271742 0.281442894801353 no 953 0.249244056141161 1157 5322280
SGTC_677 0929-0063 136 µM 0.676702484521909 0.281498591150752 no 954 0.249297369899671 1182 1539583
SGTC_3083 9117465 49.47 µM 0.676536032168593 0.281553769230379 no 955 0.249350188518504 1218 16420915
SGTC_545 4218-0007 221 µM 0.675831049977553 0.281787524939565 no 956 0.249573959227379 1197 2840508
SGTC_2999 9069765 71.4286 µM 0.672965002880357 0.282738801454477 no 957 0.25048477802495 1248 2097066
SGTC_2459 5811157 9.22 µM 0.672738326604602 0.282814103909728 no 958 0.250556889968698 1212 2870684 YBR192W RIM2
SGTC_585 0kpi-0023 191 µM 0.665070054212599 0.285367182514641 no 959 0.253002843533 1205 64601
SGTC_1568 digitonin 820 nM 0.664456429940622 0.285571956317462 no 960 0.253199113124303 1262 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1470 k295-0292 231 µM 0.664159054651922 0.285671219181942 no 961 0.253294258311948 1282 5045612
SGTC_390 dec-rvkr-cmk 16.7 µM 0.661148844917689 0.286676939988232 no 962 0.254258431718653 1293 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2884 9058502 51.95 µM 0.660711282636861 0.286823270605991 no 963 0.254398743399456 1245 6471554
SGTC_2158 5657123 3.6195 µM 0.659602474899516 0.287194239152038 no 964 0.254754482817889 1227 2858827
SGTC_2727 riluzole 51.77 µM 0.659108874303931 0.28735945378492 no 965 0.254912928714295 1249 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2681 menadione 3.18 µM 0.658546189511459 0.287547846635211 no 966 0.255093613536748 1272 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2104 5389443 200 µM 0.65723964017116 0.287985518310782 no 967 0.255513420389982 1294 2244536
SGTC_3184 9108758 49.47 µM 0.656860252773105 0.288112665489999 no 968 0.255635388789252 1263 902885
SGTC_1315 1237-0019 3.69 µM 0.656503180973444 0.28823235805384 no 969 0.255750210766636 1244 825140
SGTC_701 4424-0219 185 µM 0.656000440454848 0.288400919374525 no 970 0.255911920411371 1291 2911779
SGTC_578 3460-0051 92 µM 0.654259445084622 0.288985007703004 no 971 0.256472334555927 1315 2876744
SGTC_2079 5212404 121 µM 0.654129990798478 0.289028460674728 no 972 0.256514030502432 1274 758462
SGTC_2698 st077697 67.5 µM 0.652999293621029 0.289408124105345 no 973 0.25687836695398 1209 3154499
SGTC_2059 5238311 157 µM 0.652299276329411 0.289643291995602 no 974 0.257104063402328 1257 703021
SGTC_2844 9010103 25.97 µM 0.647838723760058 0.291143898713649 no 975 0.258544633286984 1264 2480525
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.647752961220574 0.291172786248264 no 976 0.25857237186211 1141 88881 An O-methylated flavonoid and antioxidant.
SGTC_385 1494-0393 12.4 µM 0.645375475881087 0.291974130738277 no 977 0.259341946014813 1292 3090647
SGTC_2976 9009005 19.48 µM 0.644796821684305 0.292169324585836 no 978 0.259529430940521 1297 2993148
SGTC_2407 paclitaxel 400 µM 0.644381999603711 0.292309291312959 no 979 0.259663877045908 1394 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1570 verbenone 133 µM 0.641791470973109 0.293184076267162 no 980 0.260504294104217 1294 29025 A natural terpanoid with antifungal properties.
SGTC_2034 5197015 53.07 µM 0.640473312034496 0.293629665404592 no 981 0.260932467117689 1324 780676
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.639851244800536 0.29384005722385 no 982 0.261134656696453 1290 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3271 9137798 49.47 µM 0.637773662679323 0.294543229359864 no 983 0.261810513172272 1234 6498326
SGTC_773 4358-1457 44.6 µM 0.635816396562972 0.295206389162544 no 984 0.262448049561766 1300 1186886
SGTC_2507 purpurin 79.67 µM 0.635608581344331 0.295276841344497 no 985 0.262515787444719 1268 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_342 k048-0088 23.3 µM 0.635410849077196 0.295343882452368 no 986 0.262580247072132 1266 6820570
SGTC_1564 D-Arginine 115 µM 0.631991521321686 0.296504311316392 no 987 0.263696208776451 1241 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.631695635732762 0.29660482515624 no 988 0.263792890189015 1277 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2270 7924575 90.91 µM 0.631294978548081 0.296740955311201 no 989 0.263923834805898 1298 1262135
SGTC_2101 5377231 179.231 µM 0.630856446161734 0.296889986996703 no 990 0.264067195938675 1327 2844213
SGTC_1134 3477-0009 42.5 µM 0.630556236950855 0.296992030414467 no 991 0.264165360554335 1398 3973534
SGTC_2888 9058547 12.99 µM 0.628040780116998 0.297847683196454 no 992 0.264988612850875 1232 16476514
SGTC_1913 st060213 96.1 µM 0.626775979564544 0.298278339536025 no 993 0.265403045515408 1314 688959
SGTC_714 4296-0578 26.1 µM 0.624739097326146 0.298972479924644 no 994 0.266071154102878 1296 1589775
SGTC_1935 st074532 41.6 µM 0.624376277504317 0.29909620068012 no 995 0.266190250314019 1361 2829742
SGTC_1118 chelidonine 707.474 nM 0.624131702621166 0.299179613285521 no 996 0.266270547652507 1321 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1270 0831-1170 17.3 µM 0.623440820102454 0.299415296744815 no 997 0.266497440211649 1275 6764716
SGTC_709 3807-1509 243 µM 0.622034965729444 0.299895141106509 no 998 0.266959438259835 1346 1886677 YPL242C IQG1
SGTC_1769 st044406 64.4 µM 0.621846153583152 0.299959612724543 no 999 0.267021517337702 1310 670903
SGTC_2036 5160441 105 µM 0.619475746733825 0.300769542685433 no 1000 0.267801497277478 1346 134534 YIL048W NEO1
SGTC_1874 staurosporine 7.6 µM 0.618900689809024 0.300966179030041 no 1001 0.26799089202895 1343 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1018 4259-0013 28.1 µM 0.61463957098994 0.302425038523434 no 1002 0.269396387741042 1332 6801262
SGTC_810 3825-7150 143 µM 0.614610623590339 0.302434959947277 no 1003 0.269405948430446 1348 22330411 YGL099W LSG1
SGTC_3256 9138902 49.47 µM 0.613088345035824 0.302956910793222 no 1004 0.269908963109326 1348 17228773
SGTC_62 0180-0423 3.232 µM 0.612992148620386 0.302989907652302 no 1005 0.269940765593005 1290 30102 YGL099W LSG1
SGTC_1860 st056228 74.6 µM 0.612754395567371 0.30307146752719 no 1006 0.270019374670626 1289 688679
SGTC_2640 pentamidine 10.38 µM 0.611739042485495 0.3034198892884 no 1007 0.270355213077503 1334 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_930 2810-3379 265 µM 0.610613706468749 0.303806261003101 no 1008 0.270727673247148 1457 1015764
SGTC_1463 k081-0032 34.1 µM 0.610484751401998 0.303850550317951 no 1009 0.270770370744556 1216 977755
SGTC_190 3970-0790 3.722 µM 0.610009367868454 0.304013844548122 no 1010 0.270927801016317 1350 2832352
SGTC_1920 st075728 45.7 µM 0.607815463032426 0.304767957117694 no 1011 0.271654936224334 1399 3400306
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.607305239450012 0.304943455765935 no 1012 0.271824180941194 1299 803109
SGTC_698 k064-0052 127 µM 0.606744201289395 0.305136484615763 no 1013 0.272010341752787 1382 5088751
SGTC_886 0866-0150 153 µM 0.60531992911611 0.305626758217423 no 1014 0.272483221058319 1367 271463
SGTC_1034 k072-0165 12.7 µM 0.6047444904869 0.305824938947544 no 1015 0.27267439086131 1347 5835461
SGTC_2779 methotrexate 400 µM 0.603563191108517 0.306231955944788 no 1016 0.273067045631297 1370 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1183 1254-0324 198 µM 0.603405369346321 0.306286351601464 no 1017 0.273119525578405 1379 5799357
SGTC_1844 rapamycin 4 nM 0.603272129927045 0.306332277906216 no 1018 0.273163835131432 1296 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_408 cantharidin 100 µM 0.60316291120872 0.306369926783366 no 1019 0.273200159115448 1329 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2616 abietic acid 100 µM 0.602387479651955 0.306637285215855 no 1020 0.273458121094112 1345 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2009 4012297 12.05 µM 0.601303990460041 0.307011030169245 no 1021 0.273818766109246 1329 45595307
SGTC_3051 9093778 49.47 µM 0.600970469821999 0.307126117086229 no 1022 0.273929827511934 1341 17217378
SGTC_766 1391-0721 126 µM 0.600877259630583 0.307158284231542 no 1023 0.273960870215366 1398 1020919 YIL115C NUP159
SGTC_308 4092-1169 104 µM 0.5944910439691 0.309365711535246 no 1024 0.276091865342725 1335 2268590 YDL196W YDL196W
SGTC_3067 9117431 49.47 µM 0.593247683417738 0.309796289960108 no 1025 0.276507702664118 1335 17150885
SGTC_996 3970-0799 1.8 µM 0.589648357189372 0.311044214635871 no 1026 0.27771321229126 1442 6615648 YGL040C HEM2
SGTC_1425 4048-4433 7.33 µM 0.588696367375204 0.311374644049963 no 1027 0.278032487591651 1385 23734946
SGTC_2373 9071805 200 µM 0.587443263879732 0.311809819776037 no 1028 0.278453022259176 1392 10149009
SGTC_2518 prenyletin 46.28 µM 0.58694678567701 0.311982308657953 no 1029 0.278619723301454 1300 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_282 k297-0036 65.7 µM 0.58683954309271 0.312019572817497 no 1030 0.278655738213804 1377 5061378
SGTC_1483 3453-0561 55.9 µM 0.586699673160215 0.312068177068635 no 1031 0.278702713663434 1375 4546991
SGTC_2931 9014674 55.67 µM 0.585376569705641 0.312528112078587 no 1032 0.279147269843817 1339 2996810
SGTC_890 0929-0006 47.2 µM 0.584569505271747 0.312808805975655 no 1033 0.279418608645422 1315 1378169
SGTC_2329 6138490 200 µM 0.583825913811293 0.313067520327281 no 1034 0.279668720876497 1393 720019
SGTC_2229 7354935 190 µM 0.583463410847061 0.313193677702319 no 1035 0.279790690688157 1325 318112
SGTC_2644 guaiazulene 100 µM 0.582968966097321 0.313365788381608 no 1036 0.279957095977384 1369 3515 A coloring agent.
SGTC_832 4083-0019 164 µM 0.582471767917289 0.31353889849306 no 1037 0.280124476307043 1469 1990758
SGTC_1739 st037196 92.5 µM 0.582412979132412 0.313559369773914 no 1038 0.280144270587117 1402 612214
SGTC_2233 sulbentine 40.3845 µM 0.579683243841745 0.314510542719769 no 1039 0.281064122531948 1349 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_273 hydroxyurea 18.1 mM 0.57968276298007 0.314510710384192 no 1040 0.281064284698665 1399 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2361 9034121 116 µM 0.57924466399178 0.314663480420014 no 1041 0.281212048823217 1370 6496917
SGTC_3269 9137823 49.47 µM 0.577141687239566 0.315397253392557 no 1042 0.281921872637982 1322 17682936
SGTC_1162 k048-0130 20.1 µM 0.576641143476968 0.315572011139332 no 1043 0.282090949706881 1347 6797406
SGTC_493 zm226600 134 µM 0.575549762715965 0.315953194227939 no 1044 0.282459772898934 1402 5240098 A potassium channel opener. YCR052W RSC6
SGTC_187 1488-2104 32.728 µM 0.573998459725186 0.316495349746313 no 1045 0.282984421788024 1422 2852859
SGTC_867 0518-0118 155 µM 0.570669276427081 0.317660176775681 no 1046 0.284111924441799 1404 6848158
SGTC_2812 7970281 58.44 µM 0.569426937506054 0.318095314613243 no 1047 0.284533220203885 1480 2233435
SGTC_1693 xanthone 101.9 µM 0.569242843275035 0.318159816281166 no 1048 0.284595674692464 1430 7020 An insecticide.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.568021925196307 0.318587732638258 no 1049 0.285010040181795 1380 260807
SGTC_1029 k015-0030 64.7 µM 0.566633324308693 0.319074713923201 no 1050 0.285481664653886 1424 2208316
SGTC_3050 9093513 49.47 µM 0.564846358447194 0.319701861170038 no 1051 0.286089135997708 1376 25236664
SGTC_2394 5221648 200 µM 0.564284994810318 0.319898981943254 no 1052 0.28628009583803 1526 788586
SGTC_2292 7671323 168.05 µM 0.562696878746836 0.320456918411572 no 1053 0.28682065500821 1378 937504
SGTC_2417 cerulenin 830 nM 0.558455472532951 0.32194899549966 no 1054 0.288266701097551 1454 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1994 st072947 40.9 µM 0.558244950389181 0.322023129813551 no 1055 0.288338565053421 1415 5286565 YDL195W SEC31
SGTC_2811 7967822 32.47 µM 0.558076507619692 0.322082451188437 no 1056 0.288396070853372 1460 2232244
SGTC_2148 5546263 113.568 µM 0.557171801523174 0.322401143814305 no 1057 0.288705026964042 1405 792097
SGTC_3061 glucosamine 200 µM 0.556711472030059 0.322563350051096 no 1058 0.288862288773046 1372 91431 and experimental redox chemotherapeutic
SGTC_42 0133-0086 60.653 µM 0.556512412542256 0.322633503077129 no 1059 0.288930305710355 1319 162923 Model of phenazepam hydroxylation.
SGTC_1729 st035615 45.989 µM 0.55432409610317 0.323405130639414 no 1060 0.289678531199107 1385 17385451
SGTC_2332 7982454 138.89 µM 0.553617679535029 0.32365438436154 no 1061 0.289920261992621 1411 2981748
SGTC_3085 9117376 49.47 µM 0.551030347262899 0.324567979878814 no 1062 0.290806435690072 1474 16480349
SGTC_2581 avocatin a 64 µM 0.549733574541375 0.325026272473887 no 1063 0.291251062455779 1425 6710728 A skin care supplement.
SGTC_627 1391-0720 175 µM 0.548522429791504 0.325454542529001 no 1064 0.291666616180929 1391 997839
SGTC_1863 st057641 20.1 µM 0.54517495055659 0.326639434749975 no 1065 0.292816598985765 1407 3921635
SGTC_285 1486-1325 46 µM 0.543196165504017 0.327340680678817 no 1066 0.293497373210796 1452 22310230
SGTC_1671 st016596 74.5 µM 0.54219393881661 0.327696084631302 no 1067 0.293842455175769 1417 2829167
SGTC_2540 epiandrosterone 100 µM 0.541812697339049 0.327831319341003 no 1068 0.293973771701773 1453 441302 A steroid.
SGTC_589 1227-0070 34.1 µM 0.541718227565817 0.327864833332279 no 1069 0.294006315488996 1424 2841384
SGTC_1964 st076914 61 µM 0.541683601070947 0.327877117736152 no 1070 0.294018244348866 1421 24208661
SGTC_3309 9129340 25.759 µM 0.539789792420406 0.328549265502201 no 1071 0.294671003686672 1491 17158987
SGTC_978 1416-0512 87.4 µM 0.53934984857652 0.328705489263724 no 1072 0.294822739472426 1457 6814003
SGTC_1552 6-methylflavone 10.6 µM 0.539314108476871 0.328718181864216 no 1073 0.294835067745803 1411 689013
SGTC_1610 st001799 48.1 µM 0.539238797059568 0.328744928315937 no 1074 0.294861046619768 1381 621897
SGTC_2666 tannic acid 100 µM 0.538436183916842 0.32903002659671 no 1075 0.295137975676376 1455 16134267 A thiamine antagonist.
SGTC_546 peri-Naphthalide 147 µM 0.538217051494735 0.329107882483888 no 1076 0.29521360468382 1446 223824 A penicillin ester.
SGTC_1949 st076024 69.1 µM 0.535948310575449 0.329914382003833 no 1077 0.295997137313161 1394 2921930
SGTC_2537 larixol 68.93 µM 0.535795801534299 0.329968624845414 no 1078 0.296049842080664 1440 6708759
SGTC_2749 bexarotene 57.39 µM 0.533849215473578 0.330661280181313 no 1079 0.296722930145621 1409 82146 An retinoic acid receptor inhibitor.
SGTC_1404 3909-7820 48.3 µM 0.533414987060033 0.330815871286501 no 1080 0.296873172629125 1457 23741373
SGTC_2224 6650123 117.647 µM 0.531234826096173 0.331592473377685 no 1081 0.297628031202356 1422 2908370
SGTC_443 clozapine 122 µM 0.529673298928779 0.332149155465765 no 1082 0.298169231914635 1410 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2165 5727197 32.143 µM 0.529387312806394 0.332251149277858 no 1083 0.298268398744145 1538 1361712
SGTC_72 0744-0168 198.391 µM 0.529358834244069 0.332261306524991 no 1084 0.298278274621436 1476 677577
SGTC_956 1185-0240 191 µM 0.528003499170897 0.332744846637285 no 1085 0.29874845364005 1454 1416193
SGTC_3082 9117008 49.47 µM 0.526969303173522 0.333114001906387 no 1086 0.299107452808651 1441 41448529
SGTC_728 3030-5151 22.5 µM 0.524169296798461 0.334114272516337 no 1087 0.300080396937285 1479 3125388
SGTC_2807 7945238 51.95 µM 0.522369122922984 0.334757987674751 no 1088 0.300706675069101 1493 17148797
SGTC_2322 7413319 38.22 µM 0.519440583161617 0.335806227131123 no 1089 0.30172676847477 1493 1840400
SGTC_2056 5235370 200 µM 0.518589825707434 0.336110986716043 no 1090 0.302023402793102 1426 5511916
SGTC_894 0960-0238 55.9 µM 0.517580249325278 0.336472778454388 no 1091 0.302375582466416 1469 6741907 YDL195W SEC31
SGTC_2057 5236571 38.335 µM 0.517368448892043 0.336548698476923 no 1092 0.302449490098103 1534 54684039 YBR257W POP4
SGTC_2367 9070478 135.38 µM 0.517124888794601 0.336636011011734 no 1093 0.302534490256976 1475 572802
SGTC_2565 isoliquiritigenin 100 µM 0.516882316435652 0.336722978211684 no 1094 0.302619156345996 1378 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1998 st075797 76.8 µM 0.51612270576946 0.336995370790911 no 1095 0.30288435522939 1456 24208315
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.515238664367169 0.337312491262673 no 1096 0.303193126894269 1430 16623 A steroid.
SGTC_2480 5767542 37.17 µM 0.514852752058525 0.337450960740109 no 1097 0.303327959706824 1521 2867358
SGTC_1507 4075-3230 155 µM 0.514818254816379 0.337463339792968 no 1098 0.30334001390568 1398 659771
SGTC_1375 2910-0797 186 µM 0.513127430776515 0.338070293529678 no 1099 0.303931092281497 1489 742508
SGTC_3113 9123498 49.47 µM 0.513067794681264 0.338091708748711 no 1100 0.303951949245603 1494 8897275
SGTC_292 k038-0015 474 µM 0.512599695292013 0.338259820623824 no 1101 0.304115683199563 1479 46368540
SGTC_619 1652-1634 108 µM 0.511660421945956 0.338597245816256 no 1102 0.304444345039953 1457 5400454
SGTC_3173 9105693 49.47 µM 0.511478598330426 0.338662579235827 no 1103 0.304507985336018 1503 17096658
SGTC_2744 captopril 92.04 µM 0.510204988916961 0.339120352497063 no 1104 0.304953928698532 1551 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1325 1431-0015 227 µM 0.508438005793781 0.339755852414409 no 1105 0.305573102553674 1380 1103340
SGTC_398 bronopol 33.3 µM 0.508368205251267 0.339780965723659 no 1106 0.305597573006678 1486 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2778 tioconazole 65.09 nM 0.507772226357147 0.339995419972989 no 1107 0.305806544748789 1421 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1366 1683-0113 21.9 µM 0.50707740326847 0.340245507229954 no 1108 0.306050254688144 1461 708623
SGTC_2097 5376186 200 µM 0.505565579737969 0.340789899691995 no 1109 0.306580825009964 1531 742755
SGTC_2088 5278280 127.392 µM 0.505343848868267 0.340869770672348 no 1110 0.306658674985106 1504 791502
SGTC_2092 5303694 80.6725 µM 0.504868389339204 0.341041062789447 no 1111 0.30682563880306 1430 1963699
SGTC_676 falcarinol 140 µM 0.49976598875182 0.34288134296218 no 1112 0.308619930791865 1592 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1336 1486-0901 104 µM 0.498485851582897 0.343343637023402 no 1113 0.309070819520588 1510 5006114
SGTC_1794 st048918 76.9 µM 0.496789862835246 0.343956468009534 no 1114 0.309668622264498 1473 672303
SGTC_1248 0469-0687 58.6 µM 0.496149803684228 0.344187854584736 no 1115 0.309894361588924 1553 4017482
SGTC_448 monastrol 171 µM 0.495788675832699 0.344318430983998 no 1116 0.310021757643555 1510 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_590 k048-0076 22.4 µM 0.493921405149424 0.344993893417494 no 1117 0.310680843439789 1557 6832814
SGTC_1363 1636-0063 10.4 µM 0.493876946170355 0.345009981944073 no 1118 0.310696543431969 1495 6072185
SGTC_4 0960-0234 25.671 µM 0.490752887932277 0.346141195943038 no 1119 0.311800617508466 1490 6821112
SGTC_845 0330-0138 4.51 µM 0.490262497514224 0.346318890181788 no 1120 0.311974080523402 1567 9039800
SGTC_2996 9066192 71.4286 µM 0.489919841439648 0.346443072580423 no 1121 0.3120953110646 1422 6472854
SGTC_3032 9089427 49.47 µM 0.489342420601179 0.346652373698041 no 1122 0.312299646613632 1468 17173707
SGTC_905 2-aminofluorene 215 µM 0.488705647369391 0.346883242907235 no 1123 0.31252505251864 1489 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2086 5274770 176.623 µM 0.486243232736016 0.347776553087293 no 1124 0.313397361166396 1501 689278
SGTC_1318 1280-3875 124 µM 0.485642045419027 0.347994779335727 no 1125 0.313610490225297 1505 373245
SGTC_697 0508-1955 564 µM 0.483547823254671 0.34875535825291 no 1126 0.314353406002507 1592 6243113
SGTC_2539 epi(13)torulosol 80 µM 0.483127299818528 0.34890815724307 no 1127 0.314502675603533 1468 6708597
SGTC_2661 dactinomycin 12.96 µM 0.482096794997561 0.349282699140698 no 1128 0.314868593256905 1507 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2347 9049783 174.81 µM 0.48164275237841 0.349447769718016 no 1129 0.315029875080079 1568 6467988 YPL169C MEX67
SGTC_2828 7998861 71.43 µM 0.481007396356982 0.34967880593266 no 1130 0.315255620983524 1593 2988188
SGTC_1036 k216-0215 33.5 µM 0.48091696175921 0.349711695436955 no 1131 0.315287758563803 1473 622330
SGTC_2008 4012253 172 µM 0.479156946537386 0.350352006949528 no 1132 0.315913490063929 1491 603940
SGTC_2962 9082311 13.18 µM 0.479129444531823 0.350362015841377 no 1133 0.315923271940044 1455 16459453
SGTC_2298 7976326 193.81 µM 0.477671814963209 0.350892644126756 no 1134 0.316441903967836 1456 2235818
SGTC_2576 guaiol 23.12 µM 0.476251290425078 0.351410044839732 no 1135 0.316947681400389 1636 227829
SGTC_1299 1079-1439 3.74 µM 0.474208692348882 0.352154507374383 no 1136 0.317675547719078 1460 323161
SGTC_1254 0550-0035 264 µM 0.473404174537572 0.352447884518841 no 1137 0.3179624260763 1613 15121435
SGTC_3288 9119690 36.221 µM 0.471521656496618 0.353134710324203 no 1138 0.318634129085314 1472 17595618 YKL019W RAM2
SGTC_650 1328-0195 38 µM 0.470928604100349 0.353351181321933 no 1139 0.318845860306718 1548 2780821
SGTC_1746 st038117 42 µM 0.470655690266801 0.353450813980609 no 1140 0.318943315718543 1538 2898218
SGTC_2728 chlorpromazine 9.18 µM 0.470519731937979 0.353500452038508 no 1141 0.31899187005462 1540 2726 A thorazine and dopamine antagonist.
SGTC_653 0203-0016 55.2 µM 0.470136366376065 0.353640431295986 no 1142 0.319128796820712 1562 295302
SGTC_2259 7964009 200 µM 0.468947874074498 0.354074514280885 no 1143 0.319553447682201 1558 313134
SGTC_1999 st074831 12.5 µM 0.468248815398946 0.354329925977545 no 1144 0.319803333460687 1488 17112523
SGTC_1423 4048-0112 5.59 µM 0.46785985380676 0.35447206738169 no 1145 0.319942407247937 1601 X1423
SGTC_466 geldanamycin 89.2 µM 0.467154471642769 0.354729892635917 no 1146 0.320194682234609 1525 5288382 HSP90 inhibitor.
SGTC_628 1636-0253 16 µM 0.465936166280945 0.355175353886733 no 1147 0.320630596365089 1596 4456143
SGTC_839 0122-0028 230 µM 0.464785243187936 0.35559635937135 no 1148 0.321042628242926 1538 759448
SGTC_1931 st074438 57.1 µM 0.463910232584863 0.355916554547411 no 1149 0.321356030657711 1487 2787313
SGTC_3341 9147222 25.867 µM 0.463712406544187 0.355988959704334 no 1150 0.321426903623306 1534 1939759
SGTC_1938 st074717 56.4 µM 0.463580794989734 0.35603713296031 no 1151 0.32147405825304 1462 17250979
SGTC_1806 st050005 60.3 µM 0.462638538384078 0.356382090501382 no 1152 0.321811739974269 1493 5194765
SGTC_804 1595-0054 20.9 µM 0.462141569266853 0.356564076887812 no 1153 0.321989900872305 1514 761523 Stimulates phospholipase C.
SGTC_2242 6630449 61.2675 µM 0.46094734229223 0.357001527379717 no 1154 0.322418192419873 1549 691249 YDR170C SEC7
SGTC_659 k018-0002 107 µM 0.460688213999978 0.357096472042405 no 1155 0.32251115603935 1630 6797879 YHR007C ERG11
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.459958624930124 0.357363841157215 no 1156 0.322772959502522 1496 688669
SGTC_297 0986-0032 24 µM 0.458859129890038 0.357766900262009 no 1157 0.323167664825082 1512 2847425
SGTC_527 4476-4215 268 µM 0.458398641211462 0.357935755966327 no 1158 0.323333033851907 1564 4418754
SGTC_2697 mebhydrolin 72.4 µM 0.457834122664387 0.358142796108756 no 1159 0.323535809337646 1683 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_675 1309-0189 238 µM 0.457292469724179 0.35834148939358 no 1160 0.323730420754576 1504 4246530
SGTC_523 1934-0222 13.7 µM 0.456806906886928 0.358519639888379 no 1161 0.323904920443244 1516 1361595
SGTC_1163 k060-0048 49.9 µM 0.456069275976128 0.358790331767577 no 1162 0.324170081436125 1532 6809982
SGTC_463 ikarugamyin 104 µM 0.4556042566219 0.35896101857058 no 1163 0.324337290834194 1593 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3293 9120939 62.045 µM 0.455262740078899 0.359086391220781 no 1164 0.324460114258259 1598 934087
SGTC_512 prima-1 270 µM 0.454272003260849 0.359450182137689 no 1165 0.324816532073199 1610 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3290 9121031 71.43 µM 0.45200481005136 0.360283156997302 no 1166 0.325632758632499 1516 17014854
SGTC_2216 7189485 200 µM 0.451935903495247 0.360308483922883 no 1167 0.325657579238429 1624 731273
SGTC_2149 5554786 194.827 µM 0.450887727925043 0.360693821262568 no 1168 0.326035234395492 1561 745063 YPR165W RHO1
SGTC_817 1391-0715 46 µM 0.45054563783434 0.360819613360332 no 1169 0.326158527295356 1529 1353946
SGTC_97 0535-0701 19.132 µM 0.44677926110324 0.362205564277986 no 1170 0.327517223352038 1479 2832013 YGL099W LSG1
SGTC_2223 6903751 107.57 µM 0.446283243191228 0.362388224047955 no 1171 0.327696329461055 1588 5598863
SGTC_2894 9048625 32.47 µM 0.446102427019648 0.362454817826106 no 1172 0.327761629872114 1684 4092861
SGTC_210 3551-0445 56.827 µM 0.445864730064137 0.362542366871232 no 1173 0.327847480367262 1587 2865180 YOR207C RET1
SGTC_694 1315-0438 43.2 µM 0.444546078401315 0.363028185875082 no 1174 0.328323911177623 1612 6793154
SGTC_738 1315-0003 72.4 µM 0.443759578798461 0.363318053897947 no 1175 0.328608207702764 1641 6251474
SGTC_80 0159-0065 512.242 µM 0.443300618313551 0.363487242066295 no 1176 0.328774154311486 1567 1548079
SGTC_2653 dihydrofissinolide 100 µM 0.441986503083142 0.363971816027888 no 1177 0.329249486373444 1589 6857746
SGTC_3022 9087993 49.47 µM 0.440958598090542 0.364351002996043 no 1178 0.329621485105935 1617 17173644
SGTC_3134 9127454 49.47 µM 0.440590852317503 0.364486694115088 no 1179 0.329754613249306 1612 24262820
SGTC_2862 9027634 71.43 µM 0.438917517030066 0.365104336878185 no 1180 0.330360651796349 1487 5012562
SGTC_397 arbidol 50 µM 0.438665628910713 0.365197341354947 no 1181 0.330451917717947 1646 131410 A RNA synthesis inhibitor.
SGTC_2906 7926292 26.41 µM 0.438589185989203 0.365225567890761 no 1182 0.330479617063969 1537 2966319
SGTC_324 1315-0088 19.6 µM 0.438461820365187 0.365272599247521 no 1183 0.33052577048272 1588 6787421
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.437273833319213 0.365711375896114 no 1184 0.330956384827642 1611 140250 A respiratory chain inhibitor.
SGTC_1006 4099-6547 255 µM 0.435760557620247 0.366270550634532 no 1185 0.331505231806624 1602 3146833
SGTC_770 0389-1121 67.2 µM 0.432732652469008 0.367390252182818 no 1186 0.332604502672712 1694 6753108
SGTC_514 4466-0038 2.65 nM 0.432651188890463 0.367420392566564 no 1187 0.33263409769996 1619 5722064
SGTC_1045 1348-1485 165 µM 0.432237713499574 0.36757338526373 no 1188 0.332784325882903 1544 6810614
SGTC_465 cgp-37157 41 µM 0.429672529107009 0.368523014542264 no 1189 0.333716934597009 1650 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_277 nystatin 15.5 µM 0.428202996042099 0.369067396975436 no 1190 0.334251667608122 1548 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1617 st002906 78 µM 0.427269562355759 0.369413320134428 no 1191 0.33459149988672 1577 5150859
SGTC_2458 5808907 16.39 µM 0.426937420930176 0.369536434649367 no 1192 0.334712454287998 1644 2731747
SGTC_220 paclitaxel 373.376 µM 0.426639307503165 0.369646947434482 no 1193 0.334821031478312 1616 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_721 1187-1332 279 µM 0.426442082096716 0.369720066226421 no 1194 0.334892871394196 1536 25730
SGTC_180 1486-1293 102.781 µM 0.426288584959461 0.369776976583092 no 1195 0.334948787344969 1754 4140536
SGTC_1824 st053723 68.6 µM 0.424697388492945 0.370367093909791 no 1196 0.33552864389558 1533 675225
SGTC_3283 9109332 35.8195 µM 0.424656202728339 0.37038237228115 no 1197 0.335543657833341 1541 17027281
SGTC_843 0310-0051 143 µM 0.424445835538875 0.370460413794158 no 1198 0.335620349588387 1614 2065037
SGTC_1648 st011736 69.8 µM 0.424277189641194 0.370522981493378 no 1199 0.335681836316956 1658 2855514
SGTC_3335 9143315 29.6265 µM 0.423339428382976 0.370870953745422 no 1200 0.33602381557622 1570 4899691
SGTC_2798 7813637 45.45 µM 0.422837210840619 0.371057353551932 no 1201 0.336207018236296 1639 956368
SGTC_2522 biochanin a 4.94 µM 0.42246328740822 0.371196156201224 no 1202 0.336343446085241 1644 5280373 A possible chelator.
SGTC_2558 carylophyllene oxide 100 µM 0.421820912252943 0.37143464887089 no 1203 0.336577870207595 1641 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2159 5658611 73.75 µM 0.421817708056348 0.371435838607022 no 1204 0.336579039685119 1659 793844
SGTC_2935 9038016 29.96 µM 0.421544193388476 0.371537400660657 no 1205 0.33667887373465 1611 6463195
SGTC_1976 st070609 63.5 µM 0.421454299252696 0.371570782297198 no 1206 0.33671168800092 1561 682556
SGTC_949 1165-0505 146 µM 0.420309795009281 0.371995871284311 no 1207 0.337129577658305 1574 6244267
SGTC_2421 5690543 90.72 µM 0.419198020453474 0.372408953343051 no 1208 0.337535709349483 1619 3397993
SGTC_1745 st081495 74 µM 0.414827251559924 0.374034340468868 no 1209 0.339134184240812 1639 13842402 YBL026W LSM2
SGTC_2041 5107442 45.335 µM 0.413790073281335 0.374420373143363 no 1210 0.339513927240338 1700 793005
SGTC_691 1548-0686 185 µM 0.413238787348966 0.374625610344522 no 1211 0.339715836416298 1559 46495133
SGTC_158 k038-0087 26.446 µM 0.412949195970305 0.374733436007847 no 1212 0.339821918061053 1624 X158
SGTC_1165 k072-0275 30.3 µM 0.412280726184442 0.374982369607918 no 1213 0.34006683695164 1621 6153523 YGL055W OLE1
SGTC_2905 7799065 20.05 µM 0.412161900792373 0.375026624830992 no 1214 0.34011038014441 1690 1296806
SGTC_1200 1643-0193 18.4 µM 0.411913670520356 0.375119080800561 no 1215 0.340201350230466 1630 5403974
SGTC_2290 7904846 200 µM 0.411806079566414 0.375159156409768 no 1216 0.340240782470674 1582 2962154
SGTC_1430 4049-0248 69.1 µM 0.411039409469871 0.375444765611334 no 1217 0.340521818729531 1708 22774488
SGTC_833 3852-0053 558 µM 0.41047708857789 0.37565429159711 no 1218 0.34072800355043 1666 3123681
SGTC_3277 9138724 49.47 µM 0.407251162830459 0.376857008469168 no 1219 0.341911763927269 1625 15943418
SGTC_409 arachidonic acid 100 µM 0.404580738737285 0.377853523952712 no 1220 0.34289285953497 1625 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2424 5537928 59.2 µM 0.403989273690754 0.378074349748545 no 1221 0.343110303429315 1580 5382802
SGTC_2998 9066762 71.4286 µM 0.403921664249638 0.378099594537295 no 1222 0.343135162410197 1708 4945196
SGTC_1288 0973-0013 65.5 µM 0.403795903885545 0.378146553769194 no 1223 0.343181404422003 1654 4315430
SGTC_3315 9136395 68.55 µM 0.403373385488625 0.378304336366958 no 1224 0.343336781382363 1746 16876844
SGTC_2232 chlorophetanol 41.5365 µM 0.402628611232862 0.37858250955666 no 1225 0.343610729217393 1721 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_412 gemfibrozil 100 µM 0.40238067296664 0.378675128468412 no 1226 0.343701945759177 1644 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_744 1594-0068 283 µM 0.401711396437345 0.37892517574125 no 1227 0.343948218165508 1617 668392
SGTC_528 3492-0019 172 µM 0.400835130694305 0.37925263250493 no 1228 0.344270756091241 1630 2869262
SGTC_486 niguldipine 82 µM 0.399673537400723 0.379686848494977 no 1229 0.344698492665008 1646 1236 A calcium channel blocker.
SGTC_1346 1488-2224 62.4 µM 0.398693509857242 0.380053311325292 no 1230 0.345059525304101 1719 3722427
SGTC_2390 9097792 176.6 µM 0.397913790916255 0.38034494949026 no 1231 0.345346866995282 1562 4497149
SGTC_503 tyrphostin 8 294 µM 0.397498694442189 0.380500235725399 no 1232 0.345499874549456 1720 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_864 0469-0573 172 µM 0.396263739458186 0.380962342136146 no 1233 0.345955237075058 1605 689425
SGTC_3255 9139072 49.47 µM 0.396061682131568 0.381037965922914 no 1234 0.346029762509642 1636 17646060
SGTC_1007 4101-0031 70 µM 0.395100437922146 0.381397791979749 no 1235 0.346384382846516 1740 1146276
SGTC_169 k015-0017 16.025 µM 0.394192649500869 0.381737701890809 no 1236 0.346719406060805 1710 1840002
SGTC_1196 1588-0294 184 µM 0.393541990004654 0.381981389254243 no 1237 0.346959608527082 1605 6144269
SGTC_529 4076-0302 30.3 µM 0.392423409292921 0.382400433435123 no 1238 0.347372696120312 1618 5816522
SGTC_136 0097-0015 404.482 µM 0.392017760437266 0.38255243220617 no 1239 0.347522545531621 1679 4861337
SGTC_2796 7949634 45.45 µM 0.391871285774784 0.382607321484469 no 1240 0.347576660112819 1606 2971588
SGTC_878 0828-0289 13.7 µM 0.391223146609168 0.382850230629071 no 1241 0.347816150259732 1624 745350 YLR208W SEC13
SGTC_2762 leflunomide 42.06 µM 0.391075727790454 0.382905486587543 no 1242 0.347870630614166 1664 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_152 4469-0003 551.229 µM 0.390930947578033 0.382959755855292 no 1243 0.347924138897847 1672 697280
SGTC_1253 0550-0034 176 µM 0.390916450895757 0.38296518990351 no 1244 0.347929496789837 1634 5969915
SGTC_3279 9140807 49.47 µM 0.390108488568697 0.383268089123172 no 1245 0.348228163085391 1631 45595718
SGTC_3214 9129694 49.47 µM 0.390010564469304 0.383304805011258 no 1246 0.348264367495295 1749 17158655
SGTC_510 ag-490 170 µM 0.389727393553249 0.383410983665584 no 1247 0.348369068971019 1745 5328779
SGTC_1773 st048542 73.5835 µM 0.389712902185422 0.383416417629899 no 1248 0.348374427415476 1557 3237138
SGTC_2767 sibutramine 71.45 µM 0.389342388678069 0.383555360346506 no 1249 0.348511441738754 1761 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3126 9127922 49.47 µM 0.38916490392031 0.383621922509098 no 1250 0.348577081852464 1661 45595682
SGTC_1097 itavastatin 7.23 µM 0.388203972584926 0.383982360466826 no 1251 0.348932546781923 1666 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2826 7992541 19.48 µM 0.388035325776955 0.384045628951076 no 1252 0.348994945808101 1685 2985066
SGTC_3204 9114183 49.47 µM 0.387823868776823 0.384124962206282 no 1253 0.349073190300929 1600 17027248
SGTC_2331 7980721 200 µM 0.387335734767228 0.384308116130382 no 1254 0.349253836855491 1741 2981221
SGTC_1886 st057356 49.9 µM 0.386694192841588 0.384548869886617 no 1255 0.349491307900115 1583 24207747
SGTC_1967 st070177 51.4 µM 0.386052430346102 0.38478975097665 no 1256 0.349728919539775 1695 5729214
SGTC_2447 5741742 33.78 µM 0.38503649191527 0.385171167308203 no 1257 0.35010518962269 1724 1776504
SGTC_1731 st035964 63 µM 0.384900902599942 0.385222080359828 no 1258 0.350155418574718 1615 6739575
SGTC_3047 9092122 49.47 µM 0.384805084394613 0.385258060768758 no 1259 0.350190915932139 1605 17173831
SGTC_1275 0867-0008 21.1 µM 0.383142800141839 0.385882417131636 no 1260 0.350806943284547 1667 3422836
SGTC_85 0868-0259 160.055 µM 0.382563810269413 0.386099956087874 no 1261 0.351021603871234 1678 83173
SGTC_343 4130-2827 29.8 µM 0.382513973329934 0.386118682573696 no 1262 0.35104008314802 1623 1118244
SGTC_1759 st043059 70 µM 0.377518565522899 0.387997071945814 no 1263 0.35289413502247 1595 669426
SGTC_3172 9105863 49.47 µM 0.377475145960463 0.388013410273896 no 1264 0.352910265647091 1705 2348785
SGTC_2754 granisetron 64.02 µM 0.37422470086804 0.389237079801598 no 1265 0.35411857414355 1784 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3205 9113483 49.47 µM 0.374191249519796 0.389249678703178 no 1266 0.354131016888952 1770 17018033
SGTC_182 3448-4371 550.524 µM 0.373800508783873 0.38939685341146 no 1267 0.35427637046985 1837 3491403
SGTC_2560 caryophyllene 100 µM 0.372847439388674 0.389755898896861 no 1268 0.35463099648582 1661 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2820 7989630 71.43 µM 0.370571978895922 0.390613502749571 no 1269 0.35547817798143 1801 2984098
SGTC_765 1319-0117 244 µM 0.369384923674949 0.391061106476918 no 1270 0.355920416912431 1610 3487746 YGL099W LSG1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.368771047694456 0.391292637775424 no 1271 0.356149193309621 1711 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1144 3486-0183 12.5 µM 0.36744156076515 0.391794203001108 no 1272 0.356644837671333 1688 6744069
SGTC_2531 methyl deoxycholate 70.07 µM 0.367429569543153 0.391798727656303 no 1273 0.356649309207009 1616 16667744 Haematoxylin.
SGTC_807 1315-0151 48 µM 0.367186599927728 0.391890410682962 no 1274 0.356739917001951 1811 4011080
SGTC_2450 5739737 12.93 µM 0.367022756390402 0.39195223938096 no 1275 0.356801021805151 1682 2262825
SGTC_1986 st071812 45 µM 0.366034421033876 0.392325259658663 no 1276 0.357169695478326 1669 11838594
SGTC_592 k241-0073 46.5 µM 0.365170868208774 0.392651265186456 no 1277 0.357491931371323 1756 4230158
SGTC_1091 telmisartan 47.6 µM 0.362502249145345 0.393659188339315 no 1278 0.35848837154512 1752 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_687 k029-0044 34.9 µM 0.36223833082232 0.39375890772745 no 1279 0.35858696895808 1820 5829338
SGTC_1249 0481-0015 10.2 µM 0.362060220315307 0.393826209269478 no 1280 0.358653514702708 1639 4227577
SGTC_1190 1486-1332 13 µM 0.36193251302287 0.393874467205386 no 1281 0.358701231412607 1624 4150046
SGTC_1242 0402-0103 60.1 µM 0.361058911488798 0.394204626766531 no 1282 0.359027704078018 1654 432868
SGTC_1865 st057639 52.2 µM 0.360721252256101 0.39433225844934 no 1283 0.359153917946468 1690 688818
SGTC_2124 5246320 200 µM 0.357594924743001 0.395514514935929 no 1284 0.360323238484031 1719 579342
SGTC_2801 7907800 81.82 µM 0.356718825837018 0.395845994819943 no 1285 0.360651155282514 1673 6620925
SGTC_2984 9022109 38.96 µM 0.355229201526694 0.396409780384938 no 1286 0.36120894490088 1724 6459207
SGTC_1465 k213-0056 144 µM 0.354022715755361 0.396866563968316 no 1287 0.361660929777359 1680 24048857 YMR208W ERG12
SGTC_2691 st077356 60.2 µM 0.353582075817595 0.397033428517017 no 1288 0.361826054563282 1789 2839272
SGTC_61 0978-8327 98.565 µM 0.353176357688158 0.397187085307074 no 1289 0.361978115551918 1719 6150059 YHR072W ERG7
SGTC_1607 st000305 50.6 µM 0.352953587432129 0.397271461415267 no 1290 0.362061617922857 1746 5457690
SGTC_3118 9124250 49.47 µM 0.350942627979363 0.398033346355035 no 1291 0.362815695168647 1684 1504786
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.349595662930837 0.398543883848943 no 1292 0.363321083138664 1742 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1995 st072814 61.1 µM 0.349551721331242 0.398560541876499 no 1293 0.36333757425866 1668 5769371
SGTC_3195 9113082 49.47 µM 0.347618368102148 0.39929364838799 no 1294 0.364063404936857 1840 17018038
SGTC_2316 5844804 197.44 µM 0.346803750630219 0.399602649010339 no 1295 0.364369379608485 1841 776813
SGTC_3122 9126309 49.47 µM 0.343768072503642 0.400754694574127 no 1296 0.365510356460518 1821 17591206
SGTC_124 0136-0217 7.121 µM 0.343171093991429 0.400981350988293 no 1297 0.365734874688191 1857 3976905
SGTC_3114 9122766 49.47 µM 0.342900417747466 0.401084130343199 no 1298 0.36583668874062 1665 17176985
SGTC_2879 9041815 71.43 µM 0.342638642727455 0.401183536297622 no 1299 0.365935163613844 1717 4942971
SGTC_1478 0453-0656 35.7 µM 0.341109217291304 0.401764445110529 no 1300 0.366510681266127 1726 5258496
SGTC_2927 9011802 47.9 µM 0.339586752425411 0.402342925804526 no 1301 0.367083877960365 1643 43912568
SGTC_979 1426-2828 121 µM 0.339523355230008 0.402367019057182 no 1302 0.367107752969603 1794 747872
SGTC_1645 Cervolide 78 µM 0.339467545755851 0.402388229005255 no 1303 0.367128770913181 1708 23173 A fragrance.
SGTC_2351 9026858 72.31 µM 0.338649304137484 0.402699228204307 no 1304 0.36743696779465 1648 1409300
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.3385118538393 0.402751476683349 no 1305 0.367488747870847 1692 2724 A muscle relaxant with antifungal properties.
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.337913754915579 0.4029788500497 no 1306 0.367714090866737 1741 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1265 0819-1001 68.8 µM 0.337520113964994 0.403128514554927 no 1307 0.367862426025258 1702 3106768
SGTC_2992 9074591 71.4286 µM 0.33639543553829 0.403556201753126 no 1308 0.368286345525777 1744 17741321
SGTC_869 0564-0080 44.1 µM 0.336365764896848 0.40356748632321 no 1309 0.36829753130843 1689 6843321
SGTC_2184 6075246 200 µM 0.335881584277693 0.403751645015506 no 1310 0.368480082368117 1771 2267320
SGTC_1960 st011366 51.8 µM 0.335443199331421 0.403918403675684 no 1311 0.368645392655285 1706 3972846
SGTC_3296 9122258 64.045 µM 0.334430569114282 0.40430366805621 no 1312 0.369027337598644 1734 4730474
SGTC_3228 9131799 49.47 µM 0.334351485083584 0.404333760207773 no 1313 0.369057172048282 1746 17015818
SGTC_91 0417-1751 58.384 µM 0.334056852441249 0.404445875434593 no 1314 0.369168329152114 1742 6795624
SGTC_401 neomycin 50 µM 0.332375063172601 0.405085989066743 no 1315 0.369803032976165 1761 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2678 equilin 100 µM 0.331849909717928 0.405285922288214 no 1316 0.370001297599372 1836 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_581 0958-0271 211 µM 0.331104596521638 0.405569715808292 no 1317 0.370282739881374 1684 4591145
SGTC_1202 1988-0068 29.6 µM 0.331000243965866 0.405609454182409 no 1318 0.370322150636014 1646 2850480
SGTC_3010 9080089 71.4286 µM 0.330711222240717 0.405719521283234 no 1319 0.370431312368245 1815 17027233
SGTC_1488 4013-0813 75.9 µM 0.329772885877672 0.406076915878144 no 1320 0.370785788143154 1729 2910057
SGTC_464 bw-b 70c 158 µM 0.329488705402464 0.406185170310711 no 1321 0.370893164793004 1821 5353454
SGTC_2787 5284540 71.43 µM 0.329030901960344 0.406359578976565 no 1322 0.371066165447234 1710 736958
SGTC_1910 st062352 60.4 µM 0.326720499937467 0.407240052063586 no 1323 0.371939646864009 1654 2245730
SGTC_2103 5378138 10 µM 0.325633749315726 0.407654365221261 no 1324 0.372350737249553 1787 244142
SGTC_3321 9137793 26.8275 µM 0.323349443457663 0.408525570991342 no 1325 0.373215306450561 1745 4904192
SGTC_2460 5552655 174.22 µM 0.323195592331406 0.408584264196266 no 1326 0.373273559376839 1699 5401989
SGTC_283 0987-0079 11.7 µM 0.321956792857904 0.409056932761599 no 1327 0.3737427136864 1849 411556
SGTC_1834 st055981 52.8 µM 0.321019849367624 0.409414514941213 no 1328 0.374097674370707 1864 471719 YDL150W RPC53
SGTC_2118 5526350 200 µM 0.320828065192666 0.409487718203491 no 1329 0.374170344906914 1786 743594
SGTC_1403 3909-7815 62.9 µM 0.319350359531188 0.410051858271269 no 1330 0.374730424423962 1771 6615483
SGTC_19 0279-0214 38.434 µM 0.318320546708095 0.410445117570466 no 1331 0.375120900125579 1779 3566274 YBR002C RER2
SGTC_1833 st055984 71 µM 0.316574141097523 0.411112231085442 no 1332 0.375783379856348 1757 676288
SGTC_1797 st048695 56.8 µM 0.316252655526226 0.411235064183053 no 1333 0.375905371848801 1850 592262 YIL048W NEO1
SGTC_1816 st051957 91.6 µM 0.313670192959233 0.412222085341723 no 1334 0.376885770791405 1768 674121
SGTC_1618 st003135 44.5 µM 0.313617066701843 0.412242396131172 no 1335 0.376905947857123 1858 1270615
SGTC_511 blebbistatin 171 µM 0.313565323877145 0.412262178244069 no 1336 0.376925599825736 1841 3476986 A myosin inhibitor.
SGTC_2238 6671620 73.2395 µM 0.311861704095955 0.412913623652763 no 1337 0.377572813850983 1662 729941
SGTC_1581 himbacine 57.9 µM 0.311504280935492 0.413050328831352 no 1338 0.37770864447818 1720 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3291 9121177 71.43 µM 0.311182810707733 0.413173291943717 no 1339 0.37783082492159 1732 17015612
SGTC_1499 4480-0877 67.3 µM 0.310544223738062 0.41341757820495 no 1340 0.378073567434483 1809 2861909
SGTC_1290 0986-0249 10.2 µM 0.310188808773533 0.4135535538402 no 1341 0.378208690207623 1840 53329
SGTC_2756 carbadox 75.1 µM 0.309747238543906 0.413722505434247 no 1342 0.378376588509394 1746 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3336 9143619 71.43 µM 0.309382761152338 0.41386197215183 no 1343 0.378515191094878 1865 45595730
SGTC_2790 5423970 71.43 µM 0.309087590990433 0.413974926527324 no 1344 0.378627449149092 1877 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2061 5245884 80.95 µM 0.30895407375198 0.414026022635403 no 1345 0.378678231309772 1747 573863
SGTC_1569 carminic acid 40.6 µM 0.304850149160691 0.415597271535697 no 1346 0.380240142371973 1907 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2239 6685329 187.64 µM 0.303364154174672 0.416166541290604 no 1347 0.380806180055454 1749 805680
SGTC_25 0118-0223 35.662 µM 0.303325738535395 0.416181260273997 no 1348 0.380820816535389 1851 5333628
SGTC_1756 st041558 35.5 µM 0.302757360607471 0.416399048464464 no 1349 0.38103739024026 1938 3955792
SGTC_281 1672-3440 14.9 µM 0.301656288404431 0.416821024733624 no 1350 0.381457046796108 1857 6833000
SGTC_2471 5466956 24.79 µM 0.300612328012371 0.417221201938807 no 1351 0.381855064831295 1815 724419
SGTC_525 k781-2675 26.7 µM 0.299946751710494 0.417476379466433 no 1352 0.382108886222057 1798 3651118 YDL195W SEC31
SGTC_1728 st035614 33.7865 µM 0.299293953567646 0.417726691697522 no 1353 0.382357883815497 1795 15945546
SGTC_2198 6589944 200 µM 0.299193446872493 0.417765233458545 no 1354 0.382396224531559 1843 5290268
SGTC_3346 9158254 43.5805 µM 0.298907595321774 0.417874854573955 no 1355 0.382505275838706 1773 17639500
SGTC_2742 clothiapine 36.27 µM 0.29806186472723 0.418199220853876 no 1356 0.382827973462444 1896 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3139 9095020 49.47 µM 0.296898876704381 0.418645356911442 no 1357 0.383271856892888 1763 25236292
SGTC_2981 9013952 38.96 µM 0.296854714954468 0.418662299950889 no 1358 0.383288715352393 1663 2996344
SGTC_1422 4031-0024 15.5 µM 0.295665532945632 0.419118596608929 no 1359 0.383742760821269 1886 782427
SGTC_3241 9133421 49.47 µM 0.294390430054529 0.419607982528102 no 1360 0.384229789399351 1811 17018221
SGTC_16 erodoxin 22.806 µM 0.294040320509124 0.419742376757891 no 1361 0.384363546598667 1815 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_52 0329-0193 875 nM 0.293546955685232 0.419931777328287 no 1362 0.384552056967963 1881 3739292
SGTC_1433 4060-0023 7.6 µM 0.293343731146615 0.420009799724044 no 1363 0.384629715222609 1846 3840627
SGTC_1103 duloxetine 36.1 µM 0.293247037562886 0.420046923633686 no 1364 0.384666666396741 1882 60835 A selective serotonin reuptake inhibitor.
SGTC_1743 st037606 46.3785 µM 0.290414860039986 0.42113460580151 no 1365 0.385749438341162 1786 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3326 9140064 16.379 µM 0.2903107906528 0.421174584596825 no 1366 0.385789242207127 1734 1868434
SGTC_2017 5132927 60.65 µM 0.289812152124152 0.421366150445574 no 1367 0.385979975307486 1729 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2024 5144227 134 µM 0.289060623634857 0.421654906156531 no 1368 0.386267492843239 1861 3475211
SGTC_1521 st012942 49.4 µM 0.288305342316711 0.421945146245254 no 1369 0.386556509059839 1956 24207259
SGTC_1911 st060208 74.3 µM 0.288185824443083 0.421991078555782 no 1370 0.386602249583555 1889 688783
SGTC_781 4335-2806 94.4 µM 0.286583880555549 0.422606829112751 no 1371 0.387215479199062 1921 845254
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.2851368196983 0.423163208839342 no 1372 0.387769661169921 1877 6708630 An antioxidant.
SGTC_2478 5763493 32.33 µM 0.284468617751941 0.423420177277544 no 1373 0.388025640218121 1855 1365576 YLR208W SEC13
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.284435834570824 0.423432785447358 no 1374 0.388038200260627 1768 229346 A bile salt which induces apoptosis.
SGTC_2182 6325192 200 µM 0.284278497322403 0.423493297284212 no 1375 0.388098481657561 1902 736248
SGTC_638 3970-0837 4.09 µM 0.283822241145556 0.423668783408441 no 1376 0.388273304581037 1777 4118451 YLR208W SEC13
SGTC_1668 st014914 51.6 µM 0.283789737350487 0.423681285658441 no 1377 0.388285759870646 1830 2839556
SGTC_937 3122-0005 46.7 µM 0.282902381274373 0.424022627670042 no 1378 0.388625834564877 1939 759535
SGTC_3103 9120822 49.47 µM 0.281394954167128 0.424602624875559 no 1379 0.389203743912491 1922 17141819
SGTC_1352 1496-0991 99 µM 0.281151861224369 0.424696172566007 no 1380 0.389296962575665 1780 3000039
SGTC_3097 9117246 49.47 µM 0.281056433155798 0.424732896615703 no 1381 0.389333558045241 1782 16423892
SGTC_1154 4088-0362 150 µM 0.280562867877609 0.424922848173111 no 1382 0.389522849810001 1789 6618304
SGTC_1512 0259-0544 12.2 µM 0.276313380447014 0.426559005582995 no 1383 0.391153689858614 1857 18476
SGTC_1937 st074714 47.2 µM 0.274296372352583 0.427336047748405 no 1384 0.391928436044551 1707 17250970
SGTC_1226 3909-7979 35.4 µM 0.274190957308973 0.427376666140626 no 1385 0.391968938476773 1930 6615510
SGTC_1708 st033234 31.827 µM 0.274038351087129 0.427435469542222 no 1386 0.392027574716707 1915 674664
SGTC_1487 3970-0795 2.82 µM 0.272908209270766 0.427870994559499 no 1387 0.392461887948105 1871 3765103
SGTC_688 0527-0193 473 µM 0.272232368287536 0.428131486785344 no 1388 0.392721677525201 1857 4007154
SGTC_3034 9090421 49.47 µM 0.271848875269086 0.428279312044801 no 1389 0.392869111408577 1944 17173761
SGTC_2483 5729050 27.16 µM 0.271333849589186 0.428477855101105 no 1390 0.393067137200766 1954 2865180
SGTC_574 1315-0397 40 µM 0.270840282742534 0.428668142738586 no 1391 0.393256938107329 1852 6794277
SGTC_755 1995-0008 37.3 µM 0.270151092297416 0.428933877991709 no 1392 0.393522008422431 1928 689533
SGTC_1329 1447-1697 50.6 µM 0.269986405295582 0.428997382110461 no 1393 0.393585356186739 1850 2840515
SGTC_1023 4482-3888 16 µM 0.26949461795289 0.429187028663902 no 1394 0.393774541660857 1927 3303168
SGTC_276 colchicine 750 µM 0.268838804217299 0.429439953675426 no 1395 0.394026865389356 1857 2833 A microtubule depolymerizer.
SGTC_829 1635-0120 117 µM 0.268701985532651 0.429492723635625 no 1396 0.394079511864265 1938 285054
SGTC_544 k015-0020 52.4 µM 0.267272070056183 0.430044306732641 no 1397 0.394629844825065 1818 3008304
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.266618342326698 0.430296524647455 no 1398 0.394881515786995 1801 279621
SGTC_1274 0865-0114 173 µM 0.26531250383799 0.430800421675724 no 1399 0.395384366448874 1854 870624
SGTC_1231 0242-0792 125 µM 0.265085051759467 0.430888202441975 no 1400 0.39547197125328 1801 3707635
SGTC_2366 9070441 60.58 µM 0.264968839820616 0.430933053528565 no 1401 0.395516733156738 1786 6837235
SGTC_524 r073-0010 27.8 µM 0.263824066032965 0.43137491751275 no 1402 0.395957744679998 1786 2772106
SGTC_2378 9074213 121.43 µM 0.262201658786823 0.432001287211404 no 1403 0.396582987296934 1825 657714
SGTC_405 ebelactone b 50 µM 0.260882880672958 0.432510559562481 no 1404 0.397091413529073 1836 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1450 4112-4260 37.6 µM 0.258613739071405 0.433387095660669 no 1405 0.397966640776822 1948 1633175
SGTC_2731 amoxapine 43.43 µM 0.256431917255139 0.434230210562654 no 1406 0.398808672576534 1962 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_309 k408-0051 1.48 µM 0.256285489242037 0.434286805061895 no 1407 0.398865200543325 1867 3640463
SGTC_819 1013-0258 27.7 µM 0.255633259881654 0.434538908375791 no 1408 0.399117016912797 1836 5753198
SGTC_262 fenpropimorph 62.5 µM 0.255606406941587 0.434549288294551 no 1409 0.399127385347144 1829 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3072 9116419 49.47 µM 0.255249727576566 0.434687165848058 no 1410 0.399265112827694 1818 17170162
SGTC_3095 9117207 49.47 µM 0.254928620256165 0.434811299509302 no 1411 0.399389115314238 1986 17015229
SGTC_1081 sertraline 6 µM 0.254849779419191 0.434841778781478 no 1412 0.399419562948932 1951 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_582 0987-0078 156 µM 0.25334369081578 0.43542409540568 no 1413 0.400001318324931 1941 1625765
SGTC_3198 9112019 49.47 µM 0.252809799909565 0.43563055357101 no 1414 0.400207597208874 1865 45595555
SGTC_2218 6965428 192.983 µM 0.252369211310755 0.435800944504455 no 1415 0.400377847948194 1941 675684
SGTC_38 0929-0051 58.268 µM 0.252314089167528 0.435822262993637 no 1416 0.400399149391289 2002 1379719
SGTC_2011 4012611 177 µM 0.252055666075848 0.43592221061118 no 1417 0.400499018557346 1803 2049887
SGTC_593 1203-0218 61.7 µM 0.250464381115756 0.436537745331085 no 1418 0.401114123374732 1966 3666956
SGTC_3011 9081274 71.4286 µM 0.249001686954613 0.437103674666013 no 1419 0.401679738252772 1833 6625322
SGTC_366 0181-0206 4.31 µM 0.248541854274002 0.43728161465552 no 1420 0.401857595357794 2007 274874
SGTC_1168 k815-0004 80.5 µM 0.247627092391353 0.437635634840372 no 1421 0.40221147337691 1858 642433
SGTC_1957 st077035 62.4 µM 0.247602746630391 0.437645057528464 no 1422 0.402220892694461 1948 705593
SGTC_1802 st050112 57.9 µM 0.246950780530285 0.437897405073843 no 1423 0.402473157945681 1951 4662563
SGTC_2309 7664088 163.95 µM 0.246170762802481 0.438199348978417 no 1424 0.402775023575292 2025 704922
SGTC_881 0833-0569 170 µM 0.245597589272884 0.438421246691883 no 1425 0.402996877785366 1788 5418700
SGTC_2715 st079500 56.4 µM 0.245524936614312 0.438449374739011 no 1426 0.403025001166052 1834 28246688
SGTC_792 4534-1957 155 µM 0.24471091972474 0.438764548992811 no 1427 0.40334013617793 1889 1717904
SGTC_1437 4092-1038 11.6 µM 0.244277167516131 0.438932506747159 no 1428 0.403508082801804 1873 3977136
SGTC_2741 miltefosine 3.04 µM 0.244038328323296 0.439024994879309 no 1429 0.403600567707892 1897 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2139 5578692 56.4705 µM 0.243912356936825 0.439073777403071 no 1430 0.403649349360545 2000 650991 YMR113W FOL3
SGTC_3257 9139206 32.98 µM 0.242584046587995 0.439588222869383 no 1431 0.40416382054815 1960 4910041
SGTC_597 k018-0003 82.8 µM 0.242473271354107 0.439631129977231 no 1432 0.404206732681713 1958 6786234
SGTC_2437 5741531 144.16 µM 0.242328628968743 0.43968715608031 no 1433 0.404262766014606 1999 2262990
SGTC_2650 prasterone 100 µM 0.241610411695253 0.439965369824375 no 1434 0.40454102685672 1917 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_307 1501-1223 22.3 µM 0.241284710559691 0.440091545508474 no 1435 0.404667230043177 1898 2830329
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.240234435264802 0.440498460520302 no 1436 0.405074259855584 1899 91467 include heat shock
SGTC_2145 5634607 200 µM 0.239577090330719 0.440753171960457 no 1437 0.405329063431257 1837 308662
SGTC_122 0236-0016 402.397 µM 0.239497571965765 0.440783985814982 no 1438 0.405359889490166 1883 6808838
SGTC_3086 9117350 49.47 µM 0.239244612669748 0.440882011478487 no 1439 0.40545795549737 1893 2679265
SGTC_200 k038-0079 37.545 µM 0.238947115526906 0.440997300885483 no 1440 0.405573295310527 1921 3436683
SGTC_454 lyso-paf C-16 6.67 µM 0.236220899242078 0.442054026250628 no 1441 0.406630631552378 1804 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2993 9054257 71.4286 µM 0.235027673832362 0.442516669876234 no 1442 0.407093627062377 1891 6470217 YGL055W OLE1
SGTC_2350 9023895 38.85 µM 0.234804275333783 0.442603295848312 no 1443 0.407180324633885 1940 2997209
SGTC_1369 1866-0067 208 µM 0.234620301299986 0.442674636479353 no 1444 0.40725172558308 1986 3531355
SGTC_838 0109-0203 71.4 µM 0.232779306727995 0.443388631140181 no 1445 0.407966391201613 1901 759422
SGTC_289 k017-0060 526 µM 0.232462371935816 0.443511566872374 no 1446 0.408089454800419 1905 5512909
SGTC_2065 5221596 34.26 µM 0.231950269438099 0.443710217626496 no 1447 0.408288319832651 1921 788581
SGTC_1079 idarubicin 2.36 µM 0.231428033020245 0.443912814018765 no 1448 0.408491144503969 2011 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3231 9132313 49.47 µM 0.23139304615008 0.443926387349435 no 1449 0.408504733480309 1913 4905967
SGTC_1609 st001574 46.4 µM 0.23103325305337 0.444065974688089 no 1450 0.408644484280275 1844 3960012
SGTC_2973 9094665 17.96 µM 0.230830614796181 0.44414459441343 no 1451 0.408723198127642 1998 25237061 YIL048W NEO1
SGTC_2625 euphol 100 µM 0.230492699028402 0.444275704084328 no 1452 0.408854468055202 2023 6708538 A triterpene alcohol.
SGTC_140 0062-0056 502.533 µM 0.229109824047423 0.444812316226923 no 1453 0.40939177902391 1878 3758964
SGTC_82 0054-0107 293.755 µM 0.228582014124125 0.445017154824756 no 1454 0.409596902568386 2017 3104697
SGTC_3305 9127027 53.8275 µM 0.227363297732713 0.445490184419747 no 1455 0.410070628564772 1905 41905295
SGTC_2706 st078239 82.5 µM 0.226467200972994 0.445838042772988 no 1456 0.410419033206463 1966 15434492
SGTC_1855 st056195 39.6 µM 0.226439705757485 0.445848716879675 no 1457 0.410429724533885 2028 4028379
SGTC_2293 7624732 200 µM 0.22608398377999 0.445986817690572 no 1458 0.410568050602514 1894 894453
SGTC_2838 9002687 71.43 µM 0.225505075321936 0.446211579480632 no 1459 0.410793188756231 1825 6457060
SGTC_815 1582-0027 36.9 µM 0.225260698022786 0.446306464404535 no 1460 0.410888236191026 1948 3128206
SGTC_2593 nobiletin 86.24 µM 0.225221150592482 0.446321819863479 no 1461 0.410903618151861 1847 72344 An anti-infammatory.
SGTC_2201 6605497 169.863 µM 0.224683785739354 0.446530475622112 no 1462 0.411112639615024 1996 670741
SGTC_1038 k292-0204 154 µM 0.224591305889462 0.446566386523945 no 1463 0.41114861450645 1847 4454212
SGTC_1212 0520-0165 585 µM 0.224193461761789 0.446720878591737 no 1464 0.411303385378614 2056 5403258
SGTC_1089 terbinafine 2.25 µM 0.223338940646188 0.447052736194231 no 1465 0.411635861151787 2016 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2890 9046729 58.44 µM 0.222452371181429 0.447397079121231 no 1466 0.411980873317673 1838 903329
SGTC_782 0083-0095 30.5 µM 0.222222277036803 0.44748645400906 no 1467 0.412070426536425 1901 3591729 An indicator and reagent.
SGTC_2262 9014885 67.46 µM 0.222170159113431 0.447506698413039 no 1468 0.41209071159928 2024 6457424
SGTC_3078 9116413 49.47 µM 0.221144985224556 0.447904939143244 no 1469 0.412489772049759 1953 17177322
SGTC_3123 9126162 49.47 µM 0.220725224393081 0.448068015300345 no 1470 0.412653194799453 1874 25239884
SGTC_1462 k081-0014 26.5 µM 0.220434973268041 0.448180782356652 no 1471 0.412766205235646 1951 3270634
SGTC_3298 9116858 71.43 µM 0.220234279814231 0.448258757320307 no 1472 0.412844350263353 1988 2506942
SGTC_648 0375-0473 33.3 µM 0.219048606021479 0.448719465111197 no 1473 0.413306092461551 1914 1713139
SGTC_1558 st069300 45.6 µM 0.217371252853794 0.449371338809187 no 1474 0.413959516248293 2034 24208000
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.216938924731055 0.44953937772494 no 1475 0.414127971161469 2052 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_542 3381-0244 89.3 µM 0.216902064120869 0.449553705264217 no 1476 0.414142334481295 2025 1112843
SGTC_1717 st033143 58.0435 µM 0.216503937596353 0.449708459288671 no 1477 0.414297478093882 2020 674616
SGTC_1988 st071872 53.4 µM 0.216368060112972 0.44976127738437 no 1478 0.414350430463206 2064 16414116
SGTC_2738 aclarubicin 5.55 µM 0.215308658761131 0.450173116771218 no 1479 0.414763339611424 1987 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1796 st049173 110.4 µM 0.21495219525045 0.450311703077336 no 1480 0.414902294979935 2031 94134
SGTC_9 0092-0002 10.449 µM 0.214850719984061 0.450351155860323 no 1481 0.414941853663767 1974 759368
SGTC_2789 5281112 71.43 µM 0.213832834763226 0.450746928683405 no 1482 0.415338709335743 1842 765948
SGTC_3013 9080133 71.4286 µM 0.213403941176993 0.45091370522496 no 1483 0.415505953346636 1969 17050193
SGTC_1359 1582-0056 520 nM 0.213158323537467 0.451009218276196 no 1484 0.415601737097899 1975 3661189
SGTC_303 1348-1668 34.2 µM 0.213009180921166 0.4510672165798 no 1485 0.415659900837387 1956 5380509
SGTC_1635 st007035 42.4 µM 0.211885774154719 0.451504118402381 no 1486 0.41609807460197 1964 3716403
SGTC_1061 3448-9325 110 µM 0.211194943143576 0.451772817280488 no 1487 0.416367578276003 2064 723482
SGTC_1707 st032323 6.317 µM 0.211067074060298 0.451822554416293 no 1488 0.416417466264803 1966 3132057 YMR211W DML1
SGTC_2619 obliquin 87.91 µM 0.21011007562802 0.452194821291923 no 1489 0.416790880894371 1991 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1496 4469-0713 57.4 µM 0.208867275707621 0.452678325987948 no 1490 0.41727592545588 2022 746691
SGTC_971 1315-0384 26.7 µM 0.20846441277489 0.452835072763906 no 1491 0.417433183355418 1864 6769120
SGTC_3213 9129884 49.47 µM 0.207761840914095 0.453108448505305 no 1492 0.417707464484588 1865 17190742
SGTC_2799 7812892 81.82 µM 0.207645105512716 0.45315387324246 no 1493 0.417753041381746 2022 20205235
SGTC_652 0437-0092 114 µM 0.20431947526975 0.454448216438214 no 1494 0.419051925956122 1911 3091274
SGTC_1283 0922-0125 16.4 µM 0.203861548168585 0.454626480962877 no 1495 0.419230847068124 2011 3360884
SGTC_3128 9127691 49.47 µM 0.202628720099678 0.455106448763199 no 1496 0.419712620124595 1966 41316314
SGTC_423 5-fluorouracil 457 µM 0.201217313423241 0.455656021678112 no 1497 0.420264327100041 1818 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2095 5432005 200 µM 0.19980932556715 0.456204347931006 no 1498 0.420814853826061 1954 783734
SGTC_2153 5569715 200 µM 0.199733504187944 0.456233878156243 no 1499 0.420844504577178 1978 2054701
SGTC_2193 5925765 200 µM 0.199595486885103 0.456287632507887 no 1500 0.420898478853618 2031 877370
SGTC_2946 9065502 71.43 µM 0.199403479415654 0.456362416034638 no 1501 0.420973569478668 2066 16489101
SGTC_2389 9091542 195.52 µM 0.199063657156537 0.456494774605015 no 1502 0.421106474821715 1928 3626624 YOL127W RPL25
SGTC_1681 tripelennamine 100 µM 0.198903557731407 0.456557133968571 no 1503 0.421169093227502 2079 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3064 1327-0027 10 µM 0.198890294544691 0.456562300080618 no 1504 0.421174280840949 1974 16000455 YPR107C YTH1
SGTC_3177 9107506 49.47 µM 0.198486497848037 0.456719585473812 no 1505 0.421332223878482 2064 8897194
SGTC_2589 lobaric acid 100 µM 0.198245999783413 0.45681326661247 no 1506 0.42142629949805 1900 73157 A novel microtubule depolymerizer.
SGTC_1177 0983-0204 23.6 µM 0.198021633531133 0.456900666095353 no 1507 0.421514068881464 2091 766818
SGTC_1350 1495-0454 146 µM 0.197538483804712 0.457088878996224 no 1508 0.421703084486853 2035 1069057
SGTC_1966 st070145 16.1 µM 0.196866113344484 0.457350819597367 no 1509 0.421966156167265 1960 3748532
SGTC_2708 st078559 56 µM 0.196849421498485 0.457357322606091 no 1510 0.421972687462748 2044 17250902
SGTC_2769 toremifene 3.73 µM 0.195921946399724 0.457718677325616 no 1511 0.422335629705355 1977 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1847 st056231 15 µM 0.194936721224289 0.458102570403997 no 1512 0.422721243113846 2019 5393180
SGTC_349 k015-0014 24 µM 0.194344629722934 0.458333297737299 no 1513 0.422953021142936 1894 2196908
SGTC_1774 st048371 48.465 µM 0.193554175236033 0.45864134540285 no 1514 0.423262491198455 1891 4242727
SGTC_1457 k015-0032 57.3 µM 0.193417006180607 0.458694804028618 no 1515 0.423316198946524 1935 4302660
SGTC_1102 cgs 12066b 26.1 µM 0.193379678448479 0.458709351821477 no 1516 0.423330814650222 1969 6438352 A 5-HT1B full agonist.
SGTC_164 4100-3994 89.624 µM 0.193264917228835 0.458754078229496 no 1517 0.423375750159274 2096 4615967
SGTC_1699 st031318 29.054 µM 0.193001666302329 0.45885667817282 no 1518 0.423478831552362 2034 5340658
SGTC_2172 5754775 163.918 µM 0.191281054543972 0.459527340036401 no 1519 0.424152701662112 1914 2263357
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.188935737371071 0.460441685379808 no 1520 0.42507159180143 1879 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2916 7875993 68.79 µM 0.188502294010112 0.460610690655375 no 1521 0.425241458696172 2129 1299250
SGTC_507 nimesulide 162 µM 0.187299703950256 0.461079633524087 no 1522 0.425712827546373 2075 4495 A COX2 inhibitor.
SGTC_1677 st019204 53.9 µM 0.187229430043558 0.461107038097803 no 1523 0.425740375493455 1895 3945625
SGTC_990 3985-0011 41.3 µM 0.186124848949114 0.461537813544331 no 1524 0.426173427869942 1984 5399565 YGL099W LSG1
SGTC_1714 st033236 13.627 µM 0.186011593221627 0.461581984691045 no 1525 0.426217834958626 2023 2916566
SGTC_2021 4019055 173 µM 0.185315346976222 0.461853539804466 no 1526 0.426490850680787 2016 44827708 YER133W GLC7
SGTC_156 3474-0145 5.642 µM 0.184766571195162 0.462067589935087 no 1527 0.426706064344879 2113 2265471
SGTC_1431 4049-0260 9.09 µM 0.184381842384213 0.462217660058845 no 1528 0.426856956645418 2013 3854841
SGTC_479 n-linoleoylglycine 10 µM 0.18386025111498 0.4624211243356 no 1529 0.427061544082226 1970 6433346 An anti-infammatory.
SGTC_2809 7964133 12.99 µM 0.183535505585238 0.462547807259043 no 1530 0.427188931235142 1966 1253665
SGTC_1101 ebselen 5.29 µM 0.183297255925174 0.462640750642343 no 1531 0.427282393689303 2108 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1070 indatraline 8.81 µM 0.182739258244619 0.462858438642781 no 1532 0.427501305381979 1953 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_421 streptovitacin 30 mM 0.181461954971031 0.463356786418907 no 1533 0.428002496450437 1936 91467 include heat shock
SGTC_2319 6033012 152.6 µM 0.18096979537545 0.463548820921677 no 1534 0.428195642165716 1964 847246
SGTC_1419 3993-2473 62.6 µM 0.178933764900194 0.4643433442374 no 1535 0.428994855030143 2015 704026
SGTC_718 1130-0073 349 µM 0.17851733512498 0.464505865892094 no 1536 0.4291583541961 2038 6740020
SGTC_1130 3454-2858 15.9 µM 0.178419483994467 0.464544055490505 no 1537 0.429196774390881 1902 715628 YIL048W NEO1
SGTC_2446 5162541 200 µM 0.178197473972601 0.464630703360599 no 1538 0.429283946726837 1945 1549321
SGTC_2699 st077704 54.6 µM 0.178029662366861 0.46469619934702 no 1539 0.429349840318922 2006 645852
SGTC_2990 9074105 71.4286 µM 0.17777921615097 0.464793948965362 no 1540 0.429448185216177 2057 6502001
SGTC_1432 4049-0298 68.4 µM 0.176762663634722 0.465190733033717 no 1541 0.429847408643165 2120 741646
SGTC_3117 9124945 49.47 µM 0.17599220900827 0.465491482455918 no 1542 0.430150031613204 1894 17592065
SGTC_75 0159-0059 199.013 µM 0.17448216025185 0.466080991824303 no 1543 0.430743274887125 2082 5377270
SGTC_1951 sophoraflavanone G 9.2 µM 0.173528393879529 0.466453372018464 no 1544 0.431118055664188 1885 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_400 oxethazaine 37.5 µM 0.17189979070419 0.46708929730057 no 1545 0.431758155565201 1993 4621 A local anesthetic.
SGTC_2598 perillyl alcohol 100 µM 0.17179562072908 0.467129975720961 no 1546 0.431799104245819 2029 10819 An apoptosis inducer.
SGTC_2832 7992762 51.95 µM 0.17158082659327 0.467213854007292 no 1547 0.431883541027065 1794 2985177
SGTC_407 eburnamonine 100 µM 0.171328554880672 0.46731236935145 no 1548 0.431982714427739 1962 3195
SGTC_712 r015-0009 80.6 µM 0.170212950735347 0.467748051023653 no 1549 0.432421333562953 2058 6813872 YLR060W FRS1
SGTC_2695 st077686 51.995 µM 0.169869606728183 0.46788214643116 no 1550 0.432556342006961 1968 2876092
SGTC_2353 9059630 146.67 µM 0.16965735908177 0.467965043060334 no 1551 0.432639805170666 2073 4779114
SGTC_100 0086-0128 49.5915 µM 0.16800579354239 0.468610134929339 no 1552 0.433289360639356 1892 93297
SGTC_1732 st034308 51.822 µM 0.166441650878659 0.469221155957164 no 1553 0.433904699196179 1898 830119
SGTC_2726 cimetidine 79.27 µM 0.166340409602971 0.469260707643373 no 1554 0.43394453336333 2132 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1306 1185-0270 9.02 µM 0.16630099502239 0.469276105725035 no 1555 0.43396004151798 2097 1548076
SGTC_1495 4469-0029 237 µM 0.165447228376506 0.469609657708692 no 1556 0.434295991482873 2059 793680
SGTC_2960 9079389 5.97 µM 0.165249672182481 0.469686842572063 no 1557 0.434373734946684 2099 16457355
SGTC_2040 5100729 123 µM 0.165140012144168 0.469729687051211 no 1558 0.43441689009911 2032 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1277 0873-0036 22 µM 0.165132094614329 0.469732780465508 no 1559 0.434420005960915 2089 5965735
SGTC_1291 0993-0025 5.79 µM 0.165003319563076 0.469783093709978 no 1560 0.434470684619441 2095 4353356
SGTC_3037 9091026 49.47 µM 0.164910728283085 0.469819270019459 no 1561 0.434507124034687 2088 25236398 YIL048W NEO1
SGTC_561 1550-0330 72.9 µM 0.164728296009518 0.469890548803604 no 1562 0.434578922114351 1975 6812934
SGTC_754 3474-0146 171 µM 0.161111857978914 0.47130373679391 no 1563 0.436002650468916 1908 24762078
SGTC_1788 fluconazole 20 µM 0.161005148058214 0.471345441185109 no 1564 0.436044672989423 1962 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1684 st024538 14.6195 µM 0.160658296790055 0.471480999830932 no 1565 0.436181268503464 1979 6732859
SGTC_110 0850-0284 111.64 µM 0.159879808990431 0.471785265451825 no 1566 0.436487876999652 2140 3906265
SGTC_2393 9031399 185.94 µM 0.157088101897311 0.472876515608597 no 1567 0.437587707236996 2080 1526623 YDL150W RPC53
SGTC_1298 1079-1278 263 µM 0.156378761179536 0.473153822507011 no 1568 0.437867238666191 2023 2840950
SGTC_227 fluconazole 33.516 µM 0.154692721795253 0.473813008150436 no 1569 0.43853178404479 1991 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.154689585962411 0.473814234224746 no 1570 0.438533020182277 2100 4620898
SGTC_2397 5161689 200 µM 0.15451072221126 0.473884168289353 no 1571 0.438603528819134 2083 2259942
SGTC_3331 9141060 1.957 µM 0.154476343539506 0.473897610122825 no 1572 0.438617081219844 1982 4906567 YPR165W RHO1
SGTC_2180 6301957 200 µM 0.151112349385361 0.475213050950553 no 1573 0.439943545484248 2142 845462
SGTC_1185 1319-0113 81.3 µM 0.148992324978771 0.476042195286505 no 1574 0.440779844573977 2062 4672763
SGTC_3230 9131665 49.47 µM 0.148540071093807 0.476219085924667 no 1575 0.440958282267102 2082 15943720
SGTC_2924 9010168 62.78 µM 0.148430415883842 0.476261976213884 no 1576 0.441001548760926 2031 2993929
SGTC_2943 9068529 45.32 µM 0.146225026028171 0.477124645099863 no 1577 0.441871874990081 2142 3270634
SGTC_2256 7954252 200 µM 0.14611121109789 0.47716916833516 no 1578 0.441916798111572 2014 2972920
SGTC_2635 hydroquinidine 100 µM 0.145223999667341 0.477516246088441 no 1579 0.442267008901055 2045 442912 An experimental heart treatment.
SGTC_300 r073-0011 5.04 µM 0.143861487656688 0.478049294888032 no 1580 0.442804923833938 2178 2735780
SGTC_3273 9137859 49.47 µM 0.142972796084008 0.478396994493482 no 1581 0.443155833010667 2192 2377234
SGTC_127 0180-0333 59.125 µM 0.141693354619117 0.478897603375393 no 1582 0.443661112112716 2160 771601
SGTC_155 k072-0202 43.6 µM 0.139816951382599 0.479631846334105 no 1583 0.444402309795243 2164 5857737
SGTC_3338 9144300 39.5675 µM 0.139730791579082 0.479665562636608 no 1584 0.444436348452311 2100 4901274
SGTC_2129 girgensonine 121.053 µM 0.139729916630379 0.479665905024801 no 1585 0.444436694115355 2071 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3024 9090631 49.47 µM 0.139659244259368 0.47969356085044 no 1586 0.444464614551061 2189 25236383
SGTC_713 1488-1073 324 µM 0.139007966356185 0.479948426391971 no 1587 0.444721926963801 2168 3312542
SGTC_2623 humulene 100 µM 0.138886855213485 0.479995821900987 no 1588 0.444769779156124 2045 6187145 An anti-inflammatory.
SGTC_1579 chlormadinone acetate 49.4 µM 0.137885029217929 0.480387886230863 no 1589 0.445165641169995 2169 45114258 A steroidal progestin.
SGTC_1779 st039427 55 µM 0.137568356854359 0.480511819838386 no 1590 0.445290782636285 2195 1124498
SGTC_3143 9086658 49.47 µM 0.137398056988423 0.480578469556137 no 1591 0.445358083390945 2001 25236626
SGTC_2664 lyso-paf C-16 73.48 µM 0.137327199506408 0.480606200983922 no 1592 0.44538608600276 2150 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3249 9135183 49.47 µM 0.137310438257528 0.480612760832265 no 1593 0.44539271002547 2097 4902779
SGTC_2089 5281248 129.67 µM 0.137209294837129 0.480652345434222 no 1594 0.445432682090842 2066 2737878
SGTC_87 0100-0052 35.5 µM 0.13698985718506 0.480738227623813 no 1595 0.445519406160463 2133 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_966 1300-0360 30.2 µM 0.135483933361325 0.481327630951354 no 1596 0.446114633224794 2053 70588
SGTC_1075 aripiprazole 15.2 µM 0.135357647675292 0.48137705976236 no 1597 0.446164554075273 2066 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1534 6-azauridine 81.6 µM 0.134532581044956 0.481700001730061 no 1598 0.446490724654643 2146 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2419 paclitaxel 166.5 µM 0.134466956253493 0.481725688657869 no 1599 0.44651666942122 2012 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3193 9111931 49.47 µM 0.133736403424917 0.482011647545823 no 1600 0.446805508976424 2070 17087244
SGTC_2543 pimpinellin 60.67 µM 0.133398632755158 0.482143863606814 no 1601 0.446939063324214 2021 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_403 arphamenine a 50 µM 0.130692517788535 0.483203207789955 no 1602 0.448009275757637 2088 5487158 An arginine aminopeptidase inhibitor.
SGTC_1349 flufenamic acid 69 µM 0.130032275167978 0.483461686702158 no 1603 0.448270445786319 2111 3371 A non-steroidal anti-inflammatory.
SGTC_2854 9024559 71.43 µM 0.12929534281377 0.483750197143293 no 1604 0.448561978199924 2058 3163529
SGTC_429 1112-0049 25.5 µM 0.12911793524097 0.483819653827359 no 1605 0.448632165265598 1971 2836170
SGTC_957 1187-1561 14.1 µM 0.128659142355718 0.483999277701205 no 1606 0.448813683154137 2183 1538454
SGTC_1178 0988-0033 191 µM 0.127477471685983 0.484461933269638 no 1607 0.449281251345456 2119 5392207
SGTC_302 1094-0063 18.9 µM 0.127374206717428 0.484502365260627 no 1608 0.449322114998501 2076 5440289
SGTC_2440 5628896 157.78 µM 0.126834923103658 0.484713516988883 no 1609 0.44953552715164 2086 5522048
SGTC_3088 9117578 49.47 µM 0.126421587948738 0.484875357617187 no 1610 0.449699107268096 2175 678341
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.126236238490354 0.484947931671298 no 1611 0.449772463317601 2035 2374 Ca(2+)-ATPase inhibitor.
SGTC_559 1550-0661 158 µM 0.125859256885688 0.485095541317815 no 1612 0.449921667218951 2099 5830875
SGTC_1560 lithocholic acid 53.1 µM 0.125598980124544 0.485197455602206 no 1613 0.450024685152913 2191 9903 A bile acid which acts as a detergent.
SGTC_2047 4141938 200 µM 0.12534966834009 0.485295077333781 no 1614 0.450123366290616 2082 3807862
SGTC_2914 7968218 45.32 µM 0.125184623760867 0.485359703474945 no 1615 0.45018869497112 2146 2977111
SGTC_360 0957-0399 1.01 µM 0.124660220667823 0.485565045379026 no 1616 0.450396275488476 2168 6752301 YPR165W RHO1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.124603191854636 0.485587376533757 no 1617 0.450418850679707 2127 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1400 3771-8998 51.5 µM 0.124194687421515 0.48574733867072 no 1618 0.4505805642488 2143 670767
SGTC_2300 7976697 71.57 µM 0.124051113261797 0.485803559976003 no 1619 0.450637402521441 2062 2236109
SGTC_2074 5212007 75.395 µM 0.123918930632562 0.485855320792779 no 1620 0.450689731999401 2203 758611
SGTC_3039 9090270 49.47 µM 0.123480530115056 0.486026993832162 no 1621 0.450863295505767 2223 17173750
SGTC_2237 6667747 47.222 µM 0.122519096219425 0.486403490273143 no 1622 0.451243961662975 2031 729940 YDL015C TSC13
SGTC_335 4077-0256 27.6 µM 0.121802091390236 0.486684276472177 no 1623 0.45152787879763 2181 3121989
SGTC_554 4483-2211 187 µM 0.121657589969694 0.486740865464693 no 1624 0.451585100985736 2086 747107
SGTC_3268 9137683 49.47 µM 0.121655575254578 0.486741654460201 no 1625 0.451585898814815 2058 1953228
SGTC_1841 st054148 70 µM 0.121038461524462 0.486983328753583 no 1626 0.451830285619753 2066 675442
SGTC_1241 0364-0022 50.8 µM 0.120568544803355 0.48716736091386 no 1627 0.45201639232706 2130 4563895
SGTC_1479 0549-0158 134 µM 0.120286448105693 0.487277838963159 no 1628 0.452128119504537 2132 5440202
SGTC_1873 rapamycin 2 nM 0.120117497416234 0.487344005900868 no 1629 0.452195035906103 2092 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_913 3487-1245 167 µM 0.119481313480377 0.487593160660417 no 1630 0.452447021830466 2099 4016153
SGTC_1663 st014140 55.4 µM 0.119354655009281 0.487642765702023 no 1631 0.452497192239868 2218 4207120
SGTC_2308 7584454 197.62 µM 0.119270803409737 0.487675605790614 no 1632 0.452530406930507 2167 893577
SGTC_2493 resveratrol 26.09 µM 0.119150990157478 0.487722530238026 no 1633 0.452577867067935 2151 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_172 1112-0046 2.638 µM 0.118763538727254 0.487874275415867 no 1634 0.452731348031708 2087 2802135 YIL048W NEO1
SGTC_2784 7567673 72.73 µM 0.118665020784388 0.487912860204542 no 1635 0.452770375027987 2202 3471247
SGTC_123 0083-0120 66.675 µM 0.117759555343351 0.488267493169 no 1636 0.453129088331351 2008 16001701
SGTC_1443 4112-3303 14 µM 0.117567483994692 0.488342720689688 no 1637 0.453205185116885 2156 704433
SGTC_3016 9080866 49.47 µM 0.117429175515335 0.488396891462314 no 1638 0.453259982644991 2170 17066299
SGTC_1125 tnp00248 1.32998 µM 0.114792697135288 0.489429551019004 no 1639 0.454304718816425 2213 24207736
SGTC_2871 9038510 12.99 µM 0.113041738631346 0.490115408493205 no 1640 0.454998732313087 2214 4945164
SGTC_3327 9140648 26.9345 µM 0.112932418922279 0.490158230452447 no 1641 0.455042067074897 2182 8029710
SGTC_2244 6635614 200 µM 0.112840004939049 0.490194430306362 no 1642 0.455078700757939 2050 836499
SGTC_743 1275-0778 158 µM 0.111819514101368 0.490594176190269 no 1643 0.455483257272139 2185 2849257 YMR203W TOM40
SGTC_955 1216-0110 33 µM 0.111740600871312 0.490625088418556 no 1644 0.45551454302992 2151 3619719
SGTC_515 4092-1064 102 µM 0.111649428411569 0.490660802954871 no 1645 0.455550689397196 2217 717353
SGTC_246 cycloheximide 667 µM 0.111108181865214 0.490872824317028 no 1646 0.455765280363553 2103 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1255 0566-0045 221 µM 0.110812789022463 0.490988539020712 no 1647 0.455882401820433 2118 2788469
SGTC_2948 9070189 9.45 µM 0.109488950077584 0.491507137713255 no 1648 0.456407342819677 2230 6473636 YDL196W YDL196W
SGTC_2730 imipramine 71.33 µM 0.109186047591917 0.491625798330789 no 1649 0.45652746327611 2228 3696 A tricyclic antidepressant.
SGTC_708 3448-5400 146 µM 0.108568082701032 0.491867885443819 no 1650 0.456772538693288 2223 3462195
SGTC_2064 5220758 200 µM 0.108544651208599 0.491877064766484 no 1651 0.456781831588685 2121 788518
SGTC_2785 7756463 72.73 µM 0.108448120371235 0.491914880913596 no 1652 0.456820115825843 2162 2201551
SGTC_1136 pergolide 1.05886 µM 0.106140550735526 0.492818896757157 no 1653 0.457735419005398 2071 47811 A dopamine receptor agonist.
SGTC_631 k072-0230 41.5 µM 0.105941530198306 0.492896867040593 no 1654 0.457814371563013 2162 5773147
SGTC_562 3772-2733 112 µM 0.105564317784321 0.493044648304555 no 1655 0.457964018397539 2207 2876874 YIL048W NEO1
SGTC_1862 st057513 3.81 µM 0.105485882421067 0.493075377204685 no 1656 0.457995135842114 2189 5393163
SGTC_1171 0368-0077 21.4 µM 0.102690065093045 0.494170729925982 no 1657 0.459104479432517 2136 3239779
SGTC_1706 st031321 9.9705 µM 0.102528485851257 0.494234035292241 no 1658 0.459168601772287 2218 6103185
SGTC_1143 3454-2408 5.08 µM 0.100088951132083 0.495189840885891 no 1659 0.460136853501576 2231 X1143
SGTC_547 1120-0019 610 nM 0.099374481033147 0.495469774539997 no 1660 0.460420471820187 2189 3676939
SGTC_383 2324-0395 7.37 µM 0.0992119771268083 0.495533444857892 no 1661 0.460484982702883 2182 3146421
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0982525482470967 0.495909358958657 no 1662 0.46086587840481 2159 115019
SGTC_2084 5306078 60.6385 µM 0.0978839644346809 0.496053774870436 no 1663 0.461012216680372 2165 679340
SGTC_1289 0976-0073 69.1 µM 0.097842621503147 0.496069973599111 no 1664 0.461028631331856 2172 3391136
SGTC_786 4544-0069 423 µM 0.0972706451912145 0.496294082430983 no 1665 0.461255733587798 2155 748821 YLR208W SEC13
SGTC_1055 3448-0672 86 µM 0.0966188049462382 0.496549484562354 no 1666 0.461514561088217 2157 748378
SGTC_3347 9188721 44.724 µM 0.0965159167885964 0.496589798030183 no 1667 0.461555416585673 2148 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_682 0kpi-0099 17 µM 0.0955735125524584 0.496959050868179 no 1668 0.461929651399352 2118 1714895 YML126C ERG13
SGTC_2774 tamoxifen 10.92 µM 0.0954674455092193 0.49700061022718 no 1669 0.461971773424348 2219 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1028 k015-0029 4.8 µM 0.0953722429061725 0.497037912691534 no 1670 0.462009581256367 2236 4588309
SGTC_1963 st076565 50.3 µM 0.0952552376847832 0.497083757934566 no 1671 0.462056048037485 2216 4914280
SGTC_3330 9141424 71.43 µM 0.0942329534889414 0.497484313147056 no 1672 0.462462054067623 2228 27261020
SGTC_2321 7390090 138.78 µM 0.0914889862877322 0.498559476045214 no 1673 0.463552028601763 2112 649046
SGTC_900 1112-0045 141 µM 0.0907973643588973 0.498830474769362 no 1674 0.463826802169522 2239 56211 YIL048W NEO1
SGTC_424 splitomicin 100 mM 0.0905987327839786 0.498908304829289 no 1675 0.46390571944229 2042 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_49 0717-0965 32.132 µM 0.0890625709153927 0.49951022224582 no 1676 0.464516091613346 2197 5889349 YGL099W LSG1
SGTC_2873 9040596 71.43 µM 0.088158301327125 0.49986454463941 no 1677 0.464875429473783 2101 6463863
SGTC_1948 st076329 66.6 µM 0.088014902626552 0.499920732956336 no 1678 0.46493241576351 2262 24208413
SGTC_2016 5121758 140 µM 0.087610306392489 0.499920732956336 no 1679 0.465093205182159 2254 2795203
SGTC_480 am 92016 50 µM 0.0871902665477671 0.499756147568923 no 1680 0.465260138031137 2108 2129 K+ channel blocker.
SGTC_2257 7960413 200 µM 0.0863811300090067 0.499439101476751 no 1681 0.465581723463391 2186 2974689 YIL048W NEO1
SGTC_1670 st016595 4.04 µM 0.0856914601640909 0.499168866604438 no 1682 0.465855845479776 2261 597879
SGTC_319 1348-1596 45.5 µM 0.0837260441561397 0.498398755781332 no 1683 0.466637124800934 2250 5380505
SGTC_2997 9067075 71.4286 µM 0.0822742805732143 0.497829913547286 no 1684 0.467214303098425 2195 27209819
SGTC_3180 9109287 49.47 µM 0.0805912648175964 0.49717046573844 no 1685 0.467883506637152 2202 18891271
SGTC_777 1315-0167 517 µM 0.0803047961583153 0.497058220849077 no 1686 0.467997421876696 2084 4221767
SGTC_1984 st072354 53.1 µM 0.0800025735840534 0.496939803472713 no 1687 0.468117604554853 2174 5762938
SGTC_565 1418-0001 44.5 µM 0.078759781710095 0.496452853540158 no 1688 0.468611847088825 2256 2862145
SGTC_2722 naftopidil 47.16 µM 0.0784593964159928 0.496335157528185 no 1689 0.468731313791473 2254 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_520 3584-0023 682 µM 0.0773376752224474 0.495895651194775 no 1690 0.46917746007506 2096 1340790
SGTC_3245 9134821 49.47 µM 0.0771986404384851 0.495841175723155 no 1691 0.46923276159691 2263 17014901
SGTC_69 0096-0274 206.684 µM 0.0767905226957963 0.495681270819697 no 1692 0.469395095134861 2213 6741392
SGTC_748 act1.228 77.9 µM 0.076751774259257 0.495666088802842 no 1693 0.469410508037152 2209 4421505 YNR035C ARC35
SGTC_727 3032-0951 202 µM 0.0759824067737389 0.495364644416731 no 1694 0.469716547545515 2192 3652836
SGTC_2044 5102272 200 µM 0.0745732650781391 0.49481253832199 no 1695 0.470277123126873 2200 592666
SGTC_1024 4507-0395 26 µM 0.0741050735385874 0.494629101569075 no 1696 0.470463389131863 2173 4201836
SGTC_2940 9060638 45.86 µM 0.0737053573502991 0.494472494254704 no 1697 0.470622417918798 2175 4027022
SGTC_1340 1486-1359 257 µM 0.0730627105490503 0.494220709426735 no 1698 0.470878107495212 2182 4309068
SGTC_1527 coumarin 137 µM 0.0729088918215343 0.494160444589595 no 1699 0.470939309063651 2218 323 A hepatotoxic, DNA x-linker.
SGTC_587 k089-0003 57 µM 0.0727084992641839 0.494081932731871 no 1700 0.471019042509265 2283 9659696
SGTC_2196 6573537 42.6665 µM 0.0725172058245538 0.494006986033919 no 1701 0.4710951566248 2280 2903087
SGTC_1284 0929-0043 16 µM 0.0719736484500305 0.493794027304669 no 1702 0.471311439469994 2184 1239883
SGTC_1673 st016611 27.3 µM 0.0710903663013243 0.493447972614435 no 1703 0.471662917675187 2244 5226799
SGTC_2295 7971645 200 µM 0.070748358339603 0.493313981111977 no 1704 0.471799016421847 2218 2978226 YKL099C UTP11
SGTC_3278 9139605 49.47 µM 0.0694371406365631 0.492800280807264 no 1705 0.472320833148301 2245 7958859
SGTC_159 3970-0959 50 µM 0.0690967171748772 0.492666913845606 no 1706 0.47245631704998 2252 6615653
SGTC_1492 4158-0558 28.5 µM 0.0686783236071861 0.492503001828914 no 1707 0.472622836355763 2267 3967268
SGTC_610 4215-0184 155 µM 0.0683915393740569 0.492390650491787 no 1708 0.472736978331764 2231 5605015
SGTC_1726 st035556 14.5795 µM 0.0677601638015254 0.49214330329521 no 1709 0.472988277761946 2266 5919439
SGTC_2920 7982904 15.77 µM 0.0670139145062773 0.491850957162397 no 1710 0.473285312964082 2240 6456808
SGTC_2606 farnesol 9.78 µM 0.0660054706266541 0.491455902240617 no 1711 0.473686735012432 2271 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1131 3454-3128 32.3 µM 0.065860462083373 0.491399096250685 no 1712 0.473744459446298 2205 710982
SGTC_2958 9077254 16.72 µM 0.0650830648034881 0.491094559803324 no 1713 0.474053932085577 2217 16457351
SGTC_2263 7948595 193.29 µM 0.0648442515428534 0.491001008487924 no 1714 0.474149003965499 2295 2971371
SGTC_2443 5493264 126.67 µM 0.0637106672721328 0.490556951629159 no 1715 0.474600305375144 2267 5340055
SGTC_888 0916-0002 6.97 µM 0.0636674850951756 0.490540036183185 no 1716 0.474617497667374 2277 2802138 YIL048W NEO1
SGTC_2023 5144124 124 µM 0.0628429412160318 0.490217046793686 no 1717 0.474945785639587 2256 2830192
SGTC_204 PMA1.184 62.41 µM 0.0620999048440181 0.489925990921182 no 1718 0.475241636388633 2300 2252213 YGL008C PMA1
SGTC_598 3937-0236 20.2 µM 0.0617368949137973 0.489783797707274 no 1719 0.475386179051261 2258 1379313
SGTC_802 4112-3352 742 µM 0.0617363586278411 0.489783587641735 no 1720 0.475386392591071 2258 704594
SGTC_2963 9082507 9 µM 0.0616772960216159 0.489760452579636 no 1721 0.475409910344575 2261 16459611
SGTC_813 k007-0158 173 µM 0.0609991435593142 0.489494820001336 no 1722 0.475679945563894 2269 6523916
SGTC_2654 protoveratrine a 100 µM 0.0607547981486269 0.489399110946451 no 1723 0.475777244816064 2285 5702278 A heart drug and vasodilator.
SGTC_2012 4023501 200 µM 0.060701018653055 0.48937804582925 no 1724 0.475798660205553 2222 3477460
SGTC_2141 5621638 7.665 µM 0.0606484714418941 0.48935746341934 no 1725 0.475819584957879 2293 2856238
SGTC_1817 st052116 64.4 µM 0.0595672850449562 0.488933975923308 no 1726 0.476250137416965 2277 4361398
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0592319387215491 0.488802627380016 no 1727 0.476383685435721 2305 97141
SGTC_1204 4049-0315 18.3 µM 0.0583092990943758 0.488441253938452 no 1728 0.476751130256726 2267 588402
SGTC_1310 1188-0297 994 nM 0.0582842070433407 0.488431426179575 no 1729 0.476761123541204 2250 1588352
SGTC_932 2857-0803 154 µM 0.0578566066570089 0.488263949783604 no 1730 0.476931424029642 2290 674898
SGTC_2974 9094440 9.66 µM 0.057248172601188 0.488025650619993 no 1731 0.477173752433635 2251 25236134
SGTC_1685 st024049 53.0905 µM 0.0571364339915005 0.487981887560042 no 1732 0.477218256843754 2235 1941139
SGTC_41 0478-0632 82.643 µM 0.0567088699154963 0.487814431006574 no 1733 0.477388554108744 2309 3750424
SGTC_1636 st007707 68.9 µM 0.0566165726468919 0.487778282828434 no 1734 0.47742531632858 2294 403051
SGTC_2885 9057732 51.95 µM 0.0566094492571085 0.487775492960631 no 1735 0.477428153599526 2240 6471414
SGTC_2761 levamisole 97.89 µM 0.0562874892331863 0.48764939829669 no 1736 0.477556392590008 2316 26879 An alkaline phosphatase inhibitor.
SGTC_3063 1327-0034 4 µM 0.0549003448468298 0.487106141695018 no 1737 0.478108928573472 2292 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1016 4226-1401 38 µM 0.0532577414797574 0.486462869010127 no 1738 0.4787632749012 2311 2901613
SGTC_2083 5306046 65.942 µM 0.0527004637229994 0.48624463704991 no 1739 0.47898528477168 2276 539837
SGTC_2067 5224629 34.075 µM 0.0524595077404735 0.486150279098213 no 1740 0.47908127951267 2245 2835000
SGTC_508 roscovitine 141 µM 0.0521794811693469 0.486040622145214 no 1741 0.479192841156137 2322 160355 A CDKinase inhibitor.
SGTC_2491 paeonol 100 µM 0.0515684973474925 0.485801367724525 no 1742 0.479436260700974 2232 11092 Increases levels of cortical cytochrome oxidase.
SGTC_670 4204-0025 119 µM 0.0513555087048408 0.485717964954856 no 1743 0.479521118435214 2286 719039
SGTC_991 3996-0057 64.7 µM 0.0508439018017722 0.485517630857215 no 1744 0.479724953758425 2263 715343
SGTC_1808 st050063 61.5 µM 0.0504968010404701 0.485381715852471 no 1745 0.47986324927717 2314 4011993
SGTC_1776 st049249 45.9 µM 0.050313672957874 0.485310008671725 no 1746 0.479936214062671 2270 1822314
SGTC_783 0848-0141 92.7 µM 0.0498934849902826 0.485145478116777 no 1747 0.480103634531942 2318 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_613 3914-0030 117 µM 0.0490423496995757 0.484812211807352 no 1748 0.480442773172748 2298 1145395
SGTC_485 niflumic acid 177 µM 0.0487823233819509 0.484710399298034 no 1749 0.480546384649503 2307 4488 A COX2 inhibitor.
SGTC_2287 7945887 168.79 µM 0.047962175235114 0.484389279361053 no 1750 0.480873193842324 2292 1245853
SGTC_614 0462-0418 107 µM 0.0475969503767995 0.484246282852502 no 1751 0.481018731261791 2291 5188303
SGTC_823 0417-1665 178 µM 0.0467675919522024 0.483921571656838 no 1752 0.481349229316812 2262 3429856
SGTC_478 N-arachidonylglycine 10 µM 0.0451276147670055 0.483279517831809 no 1753 0.482002795219097 2327 5283389
SGTC_3007 9078383 71.4286 µM 0.0447100251847296 0.4831160376678 no 1754 0.482169221374334 2292 6496995
SGTC_3040 9091894 49.47 µM 0.0443771484532163 0.482985723367629 no 1755 0.482301888296493 2279 25236966
SGTC_2979 9012552 45.46 µM 0.0443412744116418 0.482971679536548 no 1756 0.482316185894547 2340 17100905
SGTC_987 1497-1013 404 µM 0.0439930195181484 0.482835347158143 no 1757 0.482454984049834 2317 1676435
SGTC_1695 st026914 34.495 µM 0.043632288824312 0.482694132957405 no 1758 0.482598756719107 2306 3289191
SGTC_2817 7995342 71.43 µM 0.0412948343849 0.481779149828166 no 1759 0.483530425561601 2307 18879975
SGTC_2377 9073351 62.6 µM 0.0394948980970131 0.481074640247482 no 1760 0.484247910536893 2309 7337946 YHR072W ERG7
SGTC_1309 pyrazolanthrone 13.4 µM 0.0387606337820102 0.480787260120952 no 1761 0.484540615461791 2343 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_516 3992-2719 87.3 µM 0.0371199829611173 0.48014517010558 no 1762 0.485194669454303 2326 5350887 YDR037W KRS1
SGTC_2205 7238770 200 µM 0.036535978424061 0.479916624687898 no 1763 0.48542749560815 2339 279867
SGTC_2878 9043973 25.97 µM 0.0357414135813655 0.479605688826301 no 1764 0.485744274185282 2320 6465167
SGTC_2671 danthron 100 µM 0.0346935982443768 0.479195667834809 no 1765 0.486162032858472 2315 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1239 0337-0584 35.4 µM 0.0344779344710801 0.47911127908474 no 1766 0.486248018813308 2336 914301 YML130C ERO1
SGTC_2712 st079126 47.7 µM 0.0338831413232376 0.478878542725934 no 1767 0.48648516837211 2330 3152970
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0337240819415044 0.478816305665007 no 1768 0.486548587640061 2335 94937 An inhibitor of serotonin biosynthesis.
SGTC_630 4356-0227 183 µM 0.0337106493979466 0.478811049777149 no 1769 0.486553943404375 2348 779312
SGTC_1926 methyl fluorone black 53.6 µM 0.0336873574789469 0.478801936119978 no 1770 0.486563230260975 2347 72721 Reacts with homocysteine.
SGTC_1343 1487-0095 224 µM 0.0335116477936421 0.478733184828757 no 1771 0.486633288726834 2337 4560101 YGL055W OLE1
SGTC_2260 7964312 200 µM 0.033283082576291 0.478643753290871 no 1772 0.486724422217073 2337 231951
SGTC_1225 1216-0074 20.6 µM 0.0331402915293946 0.478587883467782 no 1773 0.486781356194686 2314 4241466
SGTC_2464 5717415 7.67 µM 0.0329145552118974 0.478499560524777 no 1774 0.486871362852265 2351 5285744
SGTC_872 0588-0139 234 µM 0.0324323521302108 0.478310894402456 no 1775 0.487063631391453 2354 2047100
SGTC_2324 6149169 200 µM 0.0316070243250691 0.477987989068731 no 1776 0.487392720794359 2333 2888231
SGTC_2718 lomofungin 53.02 µM 0.0304646064735954 0.477541047744366 no 1777 0.487848260106891 2325 5351222 A RNA synthesis inhibitor.
SGTC_144 4161-2749 112.381 µM 0.030362695989267 0.477501179277207 no 1778 0.48788889770885 2335 797501 YMR168C CEP3
SGTC_791 1348-1292 225 µM 0.0302536907532507 0.477458535516849 no 1779 0.487932364537652 2332 5437054
SGTC_657 3534-0529 86.7 µM 0.0296224674522629 0.477211600770272 no 1780 0.488184073369459 2338 1049549
SGTC_1629 st005085 44.9 µM 0.0283984909458963 0.476732805806493 no 1781 0.488672163883974 2325 24207091
SGTC_440 fluspirilene 35.1 µM 0.0283843393872073 0.476727270196769 no 1782 0.488677807264123 2329 3396 An atypical antipsychotic.
SGTC_2452 5863136 48.41 µM 0.0279779827871516 0.476568319199028 no 1783 0.488839855731263 2352 2184096
SGTC_2420 aureobasidin a 50 nM 0.0270206372995736 0.476193857425435 no 1784 0.48922163692757 2338 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1198 1612-1005 86.7 µM 0.0264710174042937 0.475978885328487 no 1785 0.489440825128203 2333 6998509
SGTC_2360 9040895 200 µM 0.0264479582771339 0.475969866395203 no 1786 0.489450021169317 2327 4914414
SGTC_2155 5570423 76 µM 0.0262108554248541 0.475877130954452 no 1787 0.489544578740558 2328 797402
SGTC_3333 9141820 12.094 µM 0.0243206382172046 0.475137878154901 no 1788 0.490298425541184 2337 1939433
SGTC_543 3844-1095 191 µM 0.0236633996766654 0.474880855961365 no 1789 0.490560550326003 2343 4230703
SGTC_163 TUB2.036 7.546 µM 0.0231309620120006 0.474672646530608 no 1790 0.490772904087448 2369 15992207 YJR013W GPI14
SGTC_125 0133-0007 11.75 µM 0.0230530842070266 0.474642193039997 no 1791 0.49080396455408 2359 26541
SGTC_1052 3253-3998 198 µM 0.0221469041311777 0.47428784953244 no 1792 0.491165385776139 2356 5450317
SGTC_2629 bisabolol 100 µM 0.0220516368389546 0.474250598349088 no 1793 0.491203382647386 2335 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1126 isoteolin 1.0172 µM 0.0219269444464544 0.474201841775292 no 1794 0.491253115689631 2367 133323
SGTC_2760 etidronate 98.04 µM 0.0218645168619157 0.474177431809475 no 1795 0.491278014723262 2367 3305 A chelator and antioxidant.
SGTC_1546 5-methoxyflavanone 78.7 µM 0.0198020320367269 0.473371029523089 no 1796 0.492100648435638 2378 147795
SGTC_2707 st078556 66.6 µM 0.0197336390821014 0.473344290699678 no 1797 0.492127927946423 2374 17250899
SGTC_174 3553-0389 74.3 µM 0.0194914967266138 0.473249623995461 no 1798 0.492224510192564 2344 738071
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.017590606307362 0.472506514760936 no 1799 0.492982725299849 2362 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1713 st033146 12.748 µM 0.0175484958184531 0.472490053711062 no 1800 0.492999522361586 2369 674619
SGTC_205 1486-1330 71.903 µM 0.0150384403188637 0.471508955311019 no 1801 0.494000756452539 2368 4118834
SGTC_66 0109-0187 42.4 µM 0.0146503112641756 0.471357263671515 no 1802 0.494155580482632 2377 759417
SGTC_1657 st012939 43.4 µM 0.0142156409544829 0.471187387347515 no 1803 0.494328970785362 2376 24207257
SGTC_359 0081-0058 15.9 µM 0.0137702304119276 0.471013319001957 no 1804 0.494506646485953 2377 3494159
SGTC_2847 9005661 71.43 µM 0.0115439585038131 0.470143366091136 no 1805 0.495394729155208 2386 2991449
SGTC_1933 st074711 15.9 µM 0.00974023814029237 0.469438636542798 no 1806 0.496114268626095 2391 17250958
SGTC_663 1486-0733 13.9 µM 0.00814194211421827 0.468814248031456 no 1807 0.496751870933171 2381 722445 YPR165W RHO1
SGTC_2247 cerulenin 830 nM 0.00626926993508638 0.468082769728724 no 1808 0.497498939539163 2391 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2534 helenine 20.12 µM 0.00601540149046641 0.467983615251799 no 1809 0.497600216484588 2397 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_336 4111-0029 111 µM 0.0059269220264217 0.467949057918093 no 1810 0.497635514054462 2374 3131175
SGTC_1104 tacrolimus 29.8 µM 0.00445992760226825 0.467376130804019 no 1811 0.498220752210417 2398 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2851 9015922 71.43 µM 0.00335683399620059 0.466945367727168 no 1812 0.498660819505683 2398 2996893
SGTC_1054 3429-0080 167 µM 0.00314725954065297 0.466863532308545 no 1813 0.498744427174629 2400 1162877
SGTC_2928 9011484 9.79 µM 0.00185959136854242 0.466360749689173 no 1814 0.499258130806393 2401 2994751
SGTC_58 0957-0393 9 µM 0.001840507899787 0.466353298764025 no 1815 0.499265743995907 2396 6997992
SGTC_1837 st055472 66.5 µM 0.000989194989191327 0.466020925274674 no 1816 0.499605368359609 2397 676091
SGTC_3165 9101544 49.47 µM 0.00088835869859159 0.465981557873085 no 1817 0.499645596201584 2401 5002184
SGTC_2966 9084041 48.03 µM 9.01644049980386e-05 0.46566994736522 no 1818 0.499964029606708 2403 17741380
SGTC_2213 7173844 200 µM 0 0.465634749014352 no 1819 0.5 2404 892728
SGTC_1539 benzyladenosine 56 µM -0.000113582635445747 0.465590409045039 no 1820 0.499954687084499 2406 92208 A nucleotide analog.
SGTC_2423 st077119 87.2 µM -0.000338934707122067 0.465502438201479 no 1821 0.499864784617622 2384 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3120 9124077 49.47 µM -0.000765642705587169 0.465335868527671 no 1822 0.499694552782903 2408 18774327 YGL155W CDC43
SGTC_1810 st050138 53 µM -0.00101644501118962 0.46523796820723 no 1823 0.499594497179158 2406 3444541
SGTC_1410 3909-8106 77.9 µM -0.00154159828274947 0.465032982202681 no 1824 0.499384991509214 2414 1039210
SGTC_732 3970-1727 52.7 µM -0.00281152083175926 0.464537324708293 no 1825 0.498878366945668 2412 1275699
SGTC_3137 9097352 49.47 µM -0.0042826629545465 0.463963198993263 no 1826 0.498291469897473 2418 44120435
SGTC_946 3434-1334 87.4 µM -0.00472053310848017 0.463792330880918 no 1827 0.498116786751071 2421 4047976
SGTC_1319 1306-0155 43.7 µM -0.00746646497733614 0.462720951682832 no 1828 0.49702133911121 2423 3122360
SGTC_208 k072-0098 12.366 µM -0.00749073837749658 0.462711482133662 no 1829 0.497011655696395 2416 5948901
SGTC_3132 9126706 49.47 µM -0.00765888363197469 0.462645885816147 no 1830 0.496944577369644 2442 850858
SGTC_2622 2-methoxyxanthone 59.94 µM -0.00838928583599772 0.462360955333152 no 1831 0.496653198435741 2436 71034 A hepatoprotective.
SGTC_2516 gossypol 71.55 µM -0.0087784903035001 0.46220913423789 no 1832 0.496497934039202 2428 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1764 st044502 93.5 µM -0.00920644240481798 0.462042204800201 no 1833 0.496327212756084 2438 8407
SGTC_145 3737-0113 38.366 µM -0.01198704524799 0.460957751148041 no 1834 0.495217975354691 2434 6849351
SGTC_1339 1486-1321 22.7 µM -0.0124482677817274 0.460777899135635 no 1835 0.495033987919459 2433 3469382
SGTC_1266 0828-0227 32.9 µM -0.0136067240432473 0.460326198886654 no 1836 0.494571869978568 2442 3913820
SGTC_854 0422-0053 192 µM -0.0138554553555996 0.460229221306432 no 1837 0.494472649895925 2434 3596728
SGTC_897 1000-0139 31.4 µM -0.0138783946549818 0.460220277647065 no 1838 0.494463499319351 2425 6151020
SGTC_970 1315-0089 19.5 µM -0.015380368513413 0.459634726502922 no 1839 0.493864362616167 2440 6811083 YLR033W RSC58
SGTC_250 brefeldin a 552.239 µM -0.0159269457760928 0.459421662601544 no 1840 0.493646336553153 2427 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_330 1488-0319 80.1 µM -0.016524806762222 0.459188620893908 no 1841 0.493407855927079 2460 6846614
SGTC_2648 atorvastatin 78.68 µM -0.0169251693503546 0.459032570408396 no 1842 0.493248156701761 2441 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_780 0109-0199 192 µM -0.0176249537219184 0.458759828600532 no 1843 0.492969024787937 2441 610414
SGTC_1958 st076513 41.9 µM -0.0193572883099221 0.458084732872078 no 1844 0.492278041504505 2449 732122 YGL099W LSG1
SGTC_2634 4'-methoxyflavone 100 µM -0.0201061397969805 0.457792940625163 no 1845 0.491979351143347 2452 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2793 7325131 81.82 µM -0.0210223163597903 0.45743598061148 no 1846 0.491613926863752 2460 4176441
SGTC_179 1273-0063 6.77 µM -0.0215640722029751 0.45722491824872 no 1847 0.491397846545867 2443 3108139
SGTC_430 0958-0115 16.4 µM -0.0228367467336928 0.456729145238682 no 1848 0.490890248003083 2472 6833180
SGTC_1571 st070080 73.4 µM -0.0228983398809032 0.456705153202427 no 1849 0.490865682316321 2456 4315245
SGTC_372 0155-0182 15.9 µM -0.0231494421735578 0.456607344356325 no 1850 0.490765533543267 2438 771486
SGTC_3281 9140613 49.47 µM -0.0237178201530103 0.456385960659626 no 1851 0.490538845788708 2460 16013766
SGTC_2496 diffractaic acid 79.83 µM -0.0243302691909705 0.456147426403796 no 1852 0.490294584475148 2442 94870 An apoptosis inducer which activates caspases.
SGTC_2568 diosmetin 100 µM -0.0246907504138014 0.456007034970074 no 1853 0.490150816466735 2452 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3189 9110682 49.47 µM -0.0267878119734244 0.455190432052066 no 1854 0.489314487183588 2477 17122418
SGTC_1925 st057770 10.1 µM -0.0291472183669737 0.454271897630021 no 1855 0.488373588483643 2467 5989122
SGTC_2514 salinomycin 42.74 µM -0.0305647249976192 0.453720169032548 no 1856 0.487808337185961 2483 23682228 A polyether potassium ionophore.
SGTC_2748 diazoxide 86.69 µM -0.0305783325552981 0.453714873066015 no 1857 0.487802911092126 2489 3019 A potassium channel activatior.
SGTC_3188 9110789 49.47 µM -0.0312055309713211 0.453470780764939 no 1858 0.48755281449337 2475 849217
SGTC_2465 5809242 33.21 µM -0.0315569610591364 0.453334019317128 no 1859 0.487412683189881 2476 2731748
SGTC_1703 st026983 48.3 µM -0.0326848613326059 0.452895126594391 no 1860 0.48696294817411 2465 1104023
SGTC_1096 rimcazole 32.2 µM -0.0331150180576767 0.45272775754747 no 1861 0.486791433320081 2454 18528119 A dopamine reuptake inhibitor.
SGTC_2585 alliin 100 µM -0.0351115535406568 0.45195103891627 no 1862 0.485995394350264 2483 87310 A garlic compound which reacts with lipids.
SGTC_2597 laccaic acid a 100 µM -0.0353162786286951 0.451871404399552 no 1863 0.485913771479612 2486 5491415 A textile dye.
SGTC_1415 3966-0071 78.1 µM -0.035593136976093 0.451763714373823 no 1864 0.485803390377838 2486 2893185
SGTC_2199 6590217 200 µM -0.0359373081465525 0.451629846523216 no 1865 0.485666173735407 2484 703109
SGTC_1004 4084-0029 199 µM -0.0371330628641923 0.451164791976979 no 1866 0.485189454922981 2489 716894 YLR208W SEC13
SGTC_1407 3909-7909 12.3 µM -0.0375330962657323 0.451009225374206 no 1867 0.485029975863004 2485 4411780
SGTC_98 0074-0023 107.663 µM -0.0380344366859539 0.450814272716686 no 1868 0.484830112689158 2514 3563821
SGTC_622 1348-1566 26.3 µM -0.0394682248252263 0.450256791443764 no 1869 0.48425854334236 2517 7340407
SGTC_458 nppb 133 µM -0.0403748620716846 0.44990432600299 no 1870 0.483897135532074 2482 4549 A chloride channel blocker.
SGTC_2355 9061122 103.12 µM -0.0406183875121865 0.449809659466045 no 1871 0.483800062569083 2502 5302957
SGTC_1843 st055809 45.5 µM -0.0407661072150286 0.44975223723599 no 1872 0.483741179705071 2573 16413835
SGTC_3224 9130643 49.47 µM -0.0416478057034329 0.44940952157832 no 1873 0.483389731419479 2539 17644395
SGTC_244 nsc-207895 1.295 µM -0.0427987608455659 0.448962202845061 no 1874 0.482930975894025 2461 42640
SGTC_2479 5617353 43.85 µM -0.0437540086234873 0.448590995015544 no 1875 0.482550243874716 2523 2731746
SGTC_2276 7947513 42.08 µM -0.0439810872768834 0.448502759205596 no 1876 0.482459739722366 2554 2105100
SGTC_36 0335-0881 14.2 µM -0.0449583061937653 0.448123070987374 no 1877 0.482070271082765 2477 23828853
SGTC_3186 9110464 49.47 µM -0.0471420980017349 0.447274753718788 no 1878 0.481199987631834 2531 17018021
SGTC_2033 5192550 145 µM -0.0475075692124965 0.447132805972324 no 1879 0.481054348894912 2503 182073
SGTC_959 1222-0044 107 µM -0.0480891732383118 0.446906926963303 no 1880 0.480822587364066 2504 6083612
SGTC_2240 6690706 185.951 µM -0.048720217278149 0.446661866295428 no 1881 0.480571131974381 2478 805876
SGTC_3317 9138495 8.753 µM -0.049270932112598 0.44644801744183 no 1882 0.480351692093375 2488 17020139
SGTC_1606 st000094 49.2 µM -0.049708146459282 0.446278253209349 no 1883 0.480177482275558 2484 1242210
SGTC_969 1313-0238 134 µM -0.0506886728250823 0.445897564346973 no 1884 0.479786801411558 2507 5212874
SGTC_1147 3809-1045 12.3 µM -0.0518911987913866 0.445430752372609 no 1885 0.479307693588078 2507 325925
SGTC_3190 9110366 49.47 µM -0.0528682810929613 0.445051511689521 no 1886 0.478918428529495 2504 17123768
SGTC_2690 usnic acid 100 µM -0.0537229029113449 0.444719843526089 no 1887 0.478577967632243 2556 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2234 tolnaftate 200 µM -0.0543551076378338 0.444474517576151 no 1888 0.478326122430705 2490 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1388 3346-4487 254 µM -0.054544608849727 0.444400986097948 no 1889 0.478250634371201 2552 3345614
SGTC_1637 st007924 17.4 µM -0.055829355674343 0.443902520967789 no 1890 0.477738874480791 2509 683336
SGTC_2802 7925815 54.55 µM -0.0574738586636891 0.443264604690497 no 1891 0.477083864721249 2526 1262923
SGTC_929 2805-0021 398 µM -0.0577222380754083 0.443168269006314 no 1892 0.476984939902042 2596 3098024
SGTC_646 4092-0839 27.3 µM -0.058902057777761 0.442710713692238 no 1893 0.476515059514904 2547 877796
SGTC_2941 9056145 11.23 µM -0.0600754817006146 0.442255714552674 no 1894 0.476047758726578 2509 2119517
SGTC_2552 juarezic acid 87.02 µM -0.0610013244124463 0.441896769598878 no 1895 0.475679077146579 2493 1549512
SGTC_2865 9030313 51.95 µM -0.0611230691759484 0.44184957325765 no 1896 0.475630598475918 2525 42562754
SGTC_1391 3442-0225 151 µM -0.061292606722867 0.44178385064062 no 1897 0.475563089356994 2528 5227075
SGTC_482 fipronil 114 µM -0.0624819526195081 0.441322836133062 no 1898 0.475089516789425 2505 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2271 7849410 118.62 µM -0.0627589409793415 0.441215481235862 no 1899 0.474979230867195 2498 972430
SGTC_433 pimozide 108 µM -0.0639317943896096 0.440760955732202 no 1900 0.474512267896423 2510 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2967 9089538 49.85 µM -0.0657568449291193 0.440053834321414 no 1901 0.473785707295656 2542 728216
SGTC_1678 st019265 80.2 µM -0.0658468008178495 0.440018985562427 no 1902 0.47374989769789 2533 5367020
SGTC_3287 9117173 37.0625 µM -0.0668793053047768 0.439619028414637 no 1903 0.473338894060036 2516 2789709
SGTC_2969 9091408 28.7 µM -0.067285265080553 0.439461790248859 no 1904 0.473177303533134 2571 4286311
SGTC_2492 derrusnin 100 µM -0.0679975031902059 0.43918594607257 no 1905 0.472893810925771 2502 1715307 Part of coumarin class of compounds.
SGTC_1665 st014639 11.4 µM -0.0701182043011664 0.438364790706028 no 1906 0.47204978871323 2547 981133 YIL048W NEO1
SGTC_2431 5490079 200 µM -0.0715280978009713 0.437819013301096 no 1907 0.471488731506284 2578 5722345
SGTC_92 0063-0024 660.874 µM -0.0716947238716418 0.437754519241964 no 1908 0.471422427549681 2504 3594437
SGTC_1900 st060200 72.8 µM -0.0723742918850575 0.437491503717619 no 1909 0.471152021616978 2523 688945
SGTC_1073 triclabendazole 3.09 µM -0.0730009776167183 0.437248979878703 no 1910 0.470902669781267 2566 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_899 1083-0020 478 µM -0.0738829244826322 0.436907711380788 no 1911 0.470551771499497 2688 767123
SGTC_2701 st077767 14.721 µM -0.0742881410953038 0.436750928923856 no 1912 0.470390556496389 2558 5721188
SGTC_2814 7977482 42.97 µM -0.0751019632431683 0.436436082836707 no 1913 0.47006679289812 2604 6456762
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0763063876062094 0.43597019711956 no 1914 0.469587672044126 2576 688788
SGTC_1989 st071868 50.2 µM -0.0766127495727564 0.435851706800821 no 1915 0.469465808036649 2532 16414057
SGTC_1514 1189-1591 158 µM -0.0771750928100089 0.435634226683153 no 1916 0.469242127798877 2653 767698 YMR146C TIF34
SGTC_260 nsc-65238 3.989 µM -0.0774057571426568 0.435545025392352 no 1917 0.469150380494353 2545 3246252
SGTC_2840 9008771 71.43 µM -0.0782627327332122 0.435213649083701 no 1918 0.46880953073653 2669 2992978
SGTC_352 k048-0007 5.11 µM -0.0785005282478558 0.435121706093577 no 1919 0.468714955020015 2535 6811911
SGTC_624 k048-0052 28 µM -0.0786271346481844 0.435072755503253 no 1920 0.468664602010349 2602 6835531
SGTC_2523 spermine 47.74 µM -0.0794760889483442 0.434744544963836 no 1921 0.468326974848464 2565 1103 A DNA binding polyamine.
SGTC_947 3447-0010 211 µM -0.0799748980690052 0.434551723489478 no 1922 0.468128610223337 2529 748350
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0804599478003051 0.434364235823599 no 1923 0.467935724971113 2548 16725076
SGTC_702 1488-0190 94 µM -0.0809545259030526 0.434173080328743 no 1924 0.467739058410478 2580 949357
SGTC_2002 4023503 131 µM -0.0812098082061361 0.434074419192134 no 1925 0.467637549730799 2536 4736863 YCR052W RSC6
SGTC_203 k066-0004 30.888 µM -0.0829247708659369 0.433411729652904 no 1926 0.466955678784442 2525 6795412
SGTC_1383 3049-0032 20.7 µM -0.0845441169675407 0.432786159678509 no 1927 0.466311914053002 2640 712864
SGTC_12 0849-0099 9.267 µM -0.0846004864414911 0.432764386598032 no 1928 0.466289506165903 2532 6071388
SGTC_368 fentichlor 4.58 µM -0.0847952231535372 0.432689169831902 no 1929 0.46621209561766 2620 7329 A pesticide.
SGTC_950 1165-0508 94.1 µM -0.0856778450161536 0.432348289064145 no 1930 0.465861257235259 2605 6148369
SGTC_459 nigericin 15.3 µM -0.0858003940022803 0.432300962926336 no 1931 0.465812546633354 2638 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2346 9031566 143.75 µM -0.086082397709298 0.43219206203322 no 1932 0.465700458135572 2651 4771086
SGTC_2098 5376439 882.5 nM -0.0862873869371085 0.432112904923815 no 1933 0.465618982422419 2653 2844116
SGTC_2861 9024595 19.48 µM -0.0869670567434575 0.431850468221541 no 1934 0.4653488488873 2529 16482810
SGTC_3107 9121808 49.47 µM -0.0871446223533639 0.431781910859795 no 1935 0.465278278382386 2554 662681
SGTC_2058 5236698 133 µM -0.0903454553303144 0.430546436526322 no 1936 0.464006349843093 2597 766665
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0907196716683008 0.430402038672344 no 1937 0.463857669677011 2666 521171
SGTC_2279 7948423 32.93 µM -0.0914919833146103 0.430104058293205 no 1938 0.463550837954629 2559 1247112
SGTC_338 4055-0136 114 µM -0.0917036653182639 0.430022392139578 no 1939 0.463466742581426 2557 2900563
SGTC_1060 3448-7350 82 µM -0.0919105386657518 0.429942584040564 no 1940 0.463384559130804 2608 570178
SGTC_3156 9099931 49.47 µM -0.092375323241783 0.429763288770256 no 1941 0.463199922392334 2586 18111053
SGTC_797 k781-0471 270 µM -0.092483497080619 0.429721561713203 no 1942 0.463156951222566 2621 23738129
SGTC_3119 9125183 49.47 µM -0.0937359453155504 0.429238498681129 no 1943 0.462659457870106 2543 22695334
SGTC_2652 actinonin 100 µM -0.0958003151711214 0.428442513099681 no 1944 0.461839583521011 2564 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.0980169010020207 0.427588159717507 no 1945 0.460959436465636 2639 1273210
SGTC_2515 chrysin 20.77 µM -0.0995319434367513 0.427004401902386 no 1946 0.460357963309557 2685 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1328 1441-0025 69.2 µM -0.103419271600184 0.425507317740286 no 1947 0.458815108815319 2582 4562601
SGTC_2716 st080858 38.6235 µM -0.103689918885479 0.425403126030566 no 1948 0.458707713546455 2619 5296050
SGTC_2986 9022445 71.43 µM -0.104781049101861 0.424983124022732 no 1949 0.458274773943385 2585 6459286
SGTC_1203 3992-3522 103 µM -0.106402835395204 0.42435901730072 no 1950 0.457631371765181 2801 5322312
SGTC_2588 indole-3-carbinol 100 µM -0.106406159824505 0.42435773816566 no 1951 0.45763005299644 2687 3712 Induces cell cycle arrest.
SGTC_3238 9133470 49.47 µM -0.106681215102468 0.424251908371063 no 1952 0.457520942862717 2647 3534688
SGTC_1530 rhein 70.4 µM -0.106930358679055 0.424156053031711 no 1953 0.457422114259483 2580 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1009 4106-0057 9.87 µM -0.107220975578579 0.424044246941973 no 1954 0.457306837623797 2581 2928005
SGTC_3208 9114115 49.47 µM -0.109037610258638 0.423345490410702 no 1955 0.456586329745094 2674 650895
SGTC_552 k242-0005 476 µM -0.109318731010067 0.423237380650189 no 1956 0.456474845216475 2699 4088318
SGTC_742 0kpi-0133 140 µM -0.109679712056003 0.423098567733211 no 1957 0.456331695382135 2722 2728852
SGTC_2281 7943571 200 µM -0.109794845431116 0.423054295948607 no 1958 0.456286039540207 2658 1244024
SGTC_222 nsc-310342 10.666 µM -0.110692738300862 0.422709066108357 no 1959 0.455930002294108 2588 432556
SGTC_1459 k035-0031 35.7 µM -0.111010403947114 0.422586941394689 no 1960 0.455804048285409 2583 3877128 YMR208W ERG12
SGTC_1854 st056233 32.9 µM -0.111549945029881 0.42237953501447 no 1961 0.45559013114457 2587 5393174
SGTC_275 trichlorophene 5.69 µM -0.113674697889343 0.421562963064511 no 1962 0.45474783532115 2694 62616
SGTC_371 0195-0006 7.36 µM -0.11367470474289 0.42156296043114 no 1963 0.454747832604589 2586 3928593
SGTC_22 0964-0034 14.468 µM -0.113890504079489 0.421480044561285 no 1964 0.454662296616302 2638 138402
SGTC_2441 5730946 39.09 µM -0.115323534273726 0.420929524573179 no 1965 0.454094342578443 2722 1774275
SGTC_752 1896-0090 130 µM -0.115941249482458 0.420692267648637 no 1966 0.453849551880814 2610 772567
SGTC_2161 5662504 8.5105 µM -0.118403770341368 0.419746730366063 no 1967 0.452873869247556 2638 2859334
SGTC_121 0557-0495 61.343 µM -0.118485672454825 0.419715290234517 no 1968 0.452841423425445 2617 3104427
SGTC_2222 6885208 172.143 µM -0.119048149722076 0.419499383418638 no 1969 0.452618604514348 2646 609514
SGTC_1859 st055998 20 µM -0.119746691871746 0.419231281859872 no 1970 0.452341905840316 2617 676301
SGTC_1751 st044839 27.194 µM -0.120858293040086 0.41880472496859 no 1971 0.451901638638204 2594 5291326
SGTC_340 k038-0059 454 µM -0.121748492083867 0.418463195942216 no 1972 0.451549103866628 2611 23733424
SGTC_294 k038-0071 157 µM -0.122328455619088 0.418240723266007 no 1973 0.451319448451664 2667 24152826
SGTC_803 4488-1585 147 µM -0.122860373660516 0.418036703722956 no 1974 0.451108832533864 2721 747204
SGTC_1914 st062367 72.6 µM -0.124377431955705 0.417454950555953 no 1975 0.450508220637779 2662 978205
SGTC_1791 st048313 56.1 µM -0.125712141234323 0.416943272909602 no 1976 0.449979895401065 2649 1204976
SGTC_161 4065-0411 162.148 µM -0.126629603908451 0.416591633535791 no 1977 0.449616782508509 2744 1906281 YLR208W SEC13
SGTC_1822 st052468 42 µM -0.126966456632754 0.416462543457808 no 1978 0.449483473686466 2661 2873678
SGTC_1674 st016616 23.6 µM -0.128378674785382 0.415921445660517 no 1979 0.448924653278271 2603 625830
SGTC_1059 3448-6867 171 µM -0.128685311824205 0.415803977307951 no 1980 0.448803329115997 2603 3934407
SGTC_139 0099-0334 718.624 µM -0.128788214411195 0.415764558454193 no 1981 0.448762615699873 2631 97690
SGTC_2069 5228469 200 µM -0.129068522624901 0.415657185196413 no 1982 0.448651714472411 2743 2835210
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.129529919434433 0.41548045889547 no 1983 0.448469176039024 2751 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2051 5263410 176 µM -0.129619368552446 0.415446199665443 no 1984 0.448433789318544 2621 227584
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.129755088852409 0.415394219687646 no 1985 0.448380098166181 2639 16486 A toxic proline analog.
SGTC_2605 digitonin 300 nM -0.130465341068039 0.415122221953037 no 1986 0.4480991367777 2633 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1475 4092-1048 11.7 µM -0.130583128360536 0.41507711813554 no 1987 0.448052545023818 2674 2881759
SGTC_825 1988-2224 89.6 µM -0.130881687835563 0.414962796963552 no 1988 0.447934450525026 2643 1180859
SGTC_1235 benzylparaben 21.5 µM -0.131907966119235 0.414569880533327 no 1989 0.447528543819442 2712 7180
SGTC_1500 4488-1866 171 µM -0.131946048873401 0.414555301978192 no 1990 0.447513482638545 2781 2900003
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.132123150444377 0.414487506825988 no 1991 0.447443442512076 2637 4174840
SGTC_3196 9111891 49.47 µM -0.132640135572657 0.414289617539374 no 1992 0.447238994624439 2592 18891510
SGTC_2288 7946289 167.31 µM -0.132967869322033 0.414164180324905 no 1993 0.447109395691563 2740 1246052
SGTC_1246 0422-0085 105 µM -0.13382030069888 0.413837960734224 no 1994 0.446772336972523 2692 264295
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.136502978660859 0.412811707397354 no 1995 0.445711834980769 2673 688801
SGTC_1032 k061-1018 98.7 µM -0.141049892061151 0.411073658127107 no 1996 0.443915264064192 2866 4005393
SGTC_1195 1502-0147 41.1 µM -0.141056420958652 0.411071163714006 no 1997 0.443912685193561 2648 817940
SGTC_1830 st055982 50.3 µM -0.142953380063973 0.4103465692856 no 1998 0.443163500128281 2636 455313 An antimicrobial agent.
SGTC_1846 st056244 14.8 µM -0.144543491236242 0.409739419257756 no 1999 0.442535657985621 2726 5393182
SGTC_1085 doxorubicin 7.67 µM -0.144995399876167 0.409566907006207 no 2000 0.442357251888255 2722 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2310 7668677 200 µM -0.145178052411444 0.409497185932095 no 2001 0.442285146987036 2817 2197143
SGTC_24 0417-1663 219 µM -0.145687625845845 0.409302689632607 no 2002 0.442083995141464 2730 4329390
SGTC_2519 cryptotanshinone 88.04 µM -0.145691852248546 0.409301076573335 no 2003 0.442082326850174 2734 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2006 4011487 200 µM -0.146198715418066 0.409107637070019 no 2004 0.44188225980666 2781 45595294
SGTC_2305 7443522 69.23 µM -0.146937182094894 0.40882584791797 no 2005 0.441590801681957 2686 5415886
SGTC_1376 2910-0861 41.3 µM -0.147284352798317 0.408693388427411 no 2006 0.441453791222048 2678 1112859
SGTC_2922 7999257 32.47 µM -0.147364236123383 0.408662911223463 no 2007 0.441422266364091 2657 2988377
SGTC_741 4582-0002 126 µM -0.147417125598606 0.408642733056798 no 2008 0.441401394462702 2667 2912688
SGTC_939 1165-0479 45.3 µM -0.148484231458824 0.40823566719177 no 2009 0.440980314741164 2686 1377347
SGTC_1159 4092-0538 61.2 µM -0.148519241227831 0.408222313788921 no 2010 0.440966501022272 2675 717301
SGTC_1987 st072290 61.9 µM -0.149056873687798 0.408017263767766 no 2011 0.440754377728762 2713 54697379
SGTC_1718 roemerine 11.9335 µM -0.150010284651692 0.407653700119897 no 2012 0.440378250550369 2747 235224 An aporphine alkaloid with mutagenic activity.
SGTC_891 0929-0073 133 µM -0.150422496195865 0.40749653633523 no 2013 0.44021564689913 2817 5603632
SGTC_3027 9089541 49.47 µM -0.15229339790766 0.406783405635003 no 2014 0.43947776594511 2773 9943819
SGTC_3140 9094243 49.47 µM -0.152332794933785 0.40676839200321 no 2015 0.439462230065515 2640 19291112
SGTC_2359 9039622 200 µM -0.153145004690519 0.406458901279113 no 2016 0.439141962918449 2691 6463596
SGTC_2735 sertaconazole 140 nM -0.153461114921805 0.406338463961586 no 2017 0.439017326414243 2670 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2303 7774051 200 µM -0.15361984334145 0.406277992116472 no 2018 0.438954744970039 2805 2953184
SGTC_65 0798-0905 34.986 µM -0.156486411996511 0.405186282065596 no 2019 0.437824814476879 3079 3602145
SGTC_2219 9098279 200 µM -0.157370648495286 0.404849675980465 no 2020 0.437476372154981 2700 902349
SGTC_557 1315-0110 16.2 µM -0.157950409747003 0.404629013980086 no 2021 0.437247937678149 2692 6833801
SGTC_106 0092-0003 11.579 µM -0.158680026345491 0.40435135888461 no 2022 0.436960487721959 2795 1072148
SGTC_757 1066-0008 322 µM -0.159104147285534 0.404189982080882 no 2023 0.436793410391417 2847 6842497
SGTC_941 3237-0776 460 µM -0.159208652726345 0.404150220562099 no 2024 0.436752243463163 2842 760008
SGTC_1472 k841-0093 193 µM -0.160681116233163 0.403590093114589 no 2025 0.436172281611835 2791 X1472
SGTC_2152 5568786 200 µM -0.16240344993499 0.402935165566516 no 2026 0.435494077125062 2664 5399883
SGTC_1614 st002383 48.6 µM -0.163470845737644 0.402529418533348 no 2027 0.435073863045318 2707 1947235
SGTC_2839 9003951 25.97 µM -0.163635422657687 0.402466867567413 no 2028 0.435009078653211 2652 2990634
SGTC_471 1-acyl-paf 4 µM -0.163773183678926 0.402414510475141 no 2029 0.434954851467156 2672 16759367
SGTC_2175 5807670 165.306 µM -0.164120753568508 0.40228242175654 no 2030 0.434818042175613 2743 241186
SGTC_2541 muurolladie-3-one 83.07 µM -0.164306429401279 0.402211863015057 no 2031 0.434744960275456 2869 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_801 0866-0028 10.1 µM -0.165823194004297 0.401635596263021 no 2032 0.434148046321589 2686 6849771
SGTC_1912 st060209 90.8 µM -0.168590031872388 0.400584938846971 no 2033 0.433059560870824 2789 688787
SGTC_1740 st038286 13.222 µM -0.168773574178112 0.400515267266846 no 2034 0.432987372433882 2900 716786
SGTC_1311 1190-0148 100 µM -0.171110592620025 0.399628426259738 no 2035 0.432068403501648 2827 1961333
SGTC_1795 st049545 62.3 µM -0.171293164637402 0.399559166408272 no 2036 0.431996627431563 2691 5291882
SGTC_3308 9128332 17.569 µM -0.173219624949061 0.398828544511607 no 2037 0.43123939916686 2861 17332805 YDL196W YDL196W
SGTC_1516 st013856 110 µM -0.173459432106534 0.398737620925175 no 2038 0.43114515647737 2840 5281404 A mutagen and neurotoxin.
SGTC_1498 4478-3555 97.6 µM -0.174853088781921 0.398209320833067 no 2039 0.430597536014827 2736 3437919
SGTC_1186 1319-0216 26 µM -0.175344039433659 0.398023258205713 no 2040 0.430404654647934 2890 4565136
SGTC_476 mead acid 10 µM -0.175426550619987 0.397991990030017 no 2041 0.43037223984038 2709 5312531 An omega 9 fatty acid.
SGTC_3181 9108277 49.47 µM -0.175877315224181 0.397821181286176 no 2042 0.430195163680977 2733 17097298
SGTC_2677 mitomycin C 100 µM -0.176150420203957 0.397717702831073 no 2043 0.430087885285169 2734 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_896 0964-0007 44.5 µM -0.177145139291324 0.397340868377799 no 2044 0.429697193263654 2675 6756758
SGTC_154 3389-1638 511.116 µM -0.178465340459505 0.396840877905882 no 2045 0.42917876925917 2820 5238686
SGTC_1066 ketoconazole 628 nM -0.179050822104696 0.39661919678993 no 2046 0.428948898080159 2874 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2070 5230947 200 µM -0.179631533498346 0.396399354838818 no 2047 0.428720923594681 2796 2835538
SGTC_1301 naphtanilide LB 4.81 µM -0.179976493501435 0.396268777707999 no 2048 0.428585511159364 2837 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_186 3455-3465 67.277 µM -0.180044482435831 0.396243043343012 no 2049 0.428558823412498 2720 755278
SGTC_389 tpck 16.7 µM -0.180289824103012 0.39615018328532 no 2050 0.428462521983109 2788 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2372 9071633 200 µM -0.181654579731665 0.395633740776198 no 2051 0.427926906464439 2731 21321366
SGTC_1068 loratadine 26.9 µM -0.182220333704244 0.395419705264835 no 2052 0.427704908071884 2773 3957 A H1 histamine antagonist.
SGTC_2747 doxorubicin 7.63 µM -0.182923551903848 0.395153708391186 no 2053 0.427429001467956 2718 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_341 1486-1430 230 µM -0.183227010887468 0.395038938131265 no 2054 0.427309950745605 2710 2054753 YPL210C SRP72
SGTC_2466 5983409 37.09 µM -0.184182865551825 0.394677486928466 no 2055 0.426935000419075 2779 2879657
SGTC_1063 disulfiram 1.84 µM -0.185556448877446 0.394158232713906 no 2056 0.426396304547423 2718 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2163 5671233 125 µM -0.186554665851237 0.393780995775409 no 2057 0.426004907014085 2867 701023
SGTC_707 0865-0008 204 µM -0.189706437813095 0.39259056287326 no 2058 0.424769587889063 2762 723043
SGTC_3276 9139060 49.47 µM -0.190224092086261 0.39239513915045 no 2059 0.424566766517587 2728 4870619
SGTC_980 1473-0395 201 µM -0.190365926605732 0.39234159882245 no 2060 0.424511198023201 2744 768876
SGTC_2296 7971656 126.45 µM -0.191095399475886 0.392066266357655 no 2061 0.4242254259546 2815 666570
SGTC_1294 1000-1494 117 µM -0.191457626888759 0.391929567200409 no 2062 0.424083537625103 2764 712797 YDL207W GLE1
SGTC_1981 st071826 47 µM -0.192159882027065 0.391664584726147 no 2063 0.423808484865949 2844 11838600
SGTC_3304 9125678 46.087 µM -0.194353365027896 0.390837240245055 no 2064 0.422949601457544 2775 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2643 anethole 100 µM -0.19464149007223 0.390728600996322 no 2065 0.422836809909629 2782 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_23 0213-0011 39.996 µM -0.196080981163224 0.390185960288613 no 2066 0.422273391067419 2894 627608
SGTC_1307 1187-1599 12.2 µM -0.196325021067588 0.390093986462199 no 2067 0.422177889237383 2752 1538471
SGTC_1889 st059080 5.18 µM -0.196560564142578 0.390005220757622 no 2068 0.422085716869821 2759 176925 Isolated from Daphnopsis sellowiana.
SGTC_3239 9133757 49.47 µM -0.19704182658219 0.389823872193782 no 2069 0.421897403236328 2746 17036923
SGTC_983 1491-0821 12.2 µM -0.197307143766347 0.389723906037406 no 2070 0.421793594658354 2907 46495113
SGTC_142 0335-0849 62.6745 µM -0.19773090641174 0.389564255964078 no 2071 0.421627803638808 2773 3889043 YPR107C YTH1
SGTC_972 1319-0219 195 µM -0.20045130266097 0.388539807637295 no 2072 0.42056381992283 2835 23903702
SGTC_837 0091-0265 12.5 µM -0.200810682951419 0.38840452979361 no 2073 0.420423304648538 2766 759367
SGTC_1630 st005209 31.3 µM -0.201432059099387 0.388170663473976 no 2074 0.420180374691222 2747 3367314
SGTC_1158 4092-0494 91.8 µM -0.201609731780907 0.388103800549264 no 2075 0.420110918298033 2892 1148199
SGTC_1209 2323-2347 50.3 µM -0.201865738905338 0.388007464136888 no 2076 0.420010843520573 2745 5412760
SGTC_2426 5582046 32.21 µM -0.20215126443625 0.387900027970436 no 2077 0.419899235915156 2907 2251934
SGTC_852 0418-0143 439 µM -0.202381690084105 0.387813330777625 no 2078 0.419809170716083 2866 5369229
SGTC_44 0929-0055 61.211 µM -0.203056582791914 0.387559435926818 no 2079 0.419545403316842 2775 1379590
SGTC_346 4513-0042 7.16 µM -0.206131735160931 0.386403172764095 no 2080 0.418344004984601 2775 2827372
SGTC_910 3454-3003 490 µM -0.207532745786472 0.385876723679918 no 2081 0.417796910931463 2839 820824
SGTC_3343 9148379 18.9835 µM -0.207665118241448 0.385826993751459 no 2082 0.41774522775169 2921 1955036
SGTC_2208 7283366 200 µM -0.208367032459679 0.385563328693148 no 2083 0.417471197830004 2842 898663
SGTC_2816 7982706 58.44 µM -0.208618050323988 0.385469049886455 no 2084 0.417373209243904 2885 2981853
SGTC_3146 9095609 49.47 µM -0.208875201417297 0.385372474541806 no 2085 0.417272831780788 2846 17173999
SGTC_2853 9015042 58.44 µM -0.212575895654642 0.383983436348676 no 2086 0.415828887104575 2738 6457456
SGTC_2909 7941780 10.49 µM -0.212669408876033 0.383948355815262 no 2087 0.415792414548045 2838 1243215
SGTC_1644 st010134 20.9 µM -0.213408292025791 0.383671204782119 no 2088 0.41550425668711 2815 3818134
SGTC_2611 pyromycin 23.93 µM -0.216978802561714 0.382332766630292 no 2089 0.414112432263302 2826 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3235 9132602 49.47 µM -0.217608819417214 0.382096744453817 no 2090 0.41386695613028 2891 4912240
SGTC_55 0767-0285 6.563 µM -0.218959055765933 0.381591055291734 no 2091 0.413340971293461 2913 3116166
SGTC_948 3448-0295 75.3 µM -0.219978766700363 0.381209288028947 no 2092 0.412943845697788 2791 678569
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.219987189695786 0.381206135043586 no 2093 0.412940565739427 2780 66535 A nucleotide analog.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.221083673347994 0.380795755005185 no 2094 0.412513641257814 2770 6312947
SGTC_719 2810-4230 27.3 µM -0.221918383768498 0.380483438471779 no 2095 0.412188709576376 2778 721079
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.223144648176828 0.380024758803781 no 2096 0.411711465032477 2795 688664
SGTC_2827 7993847 71.43 µM -0.223535925816441 0.379878438321377 no 2097 0.411559212825448 2917 2985692
SGTC_1518 st038567 90.8 µM -0.224127888103421 0.37965710337328 no 2098 0.411328896424454 2770 77966
SGTC_2843 9000894 45.46 µM -0.224295406937491 0.379594475164654 no 2099 0.411263724952831 2759 2242070
SGTC_457 grayanotoxin iii 135 µM -0.22478394846752 0.379411848188227 no 2100 0.411073676908099 2848 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2144 5628481 200 µM -0.22489884350068 0.379368901943269 no 2101 0.411028984502234 2801 2818399
SGTC_2621 lithochol-11-enic acid 100 µM -0.225354618197207 0.379198554053797 no 2102 0.410851706517294 2841 6708711
SGTC_1454 4239-0054 42.6 µM -0.225370293722611 0.379192695671088 no 2103 0.410845609693457 2990 1340767
SGTC_2549 cedrol 20.94 µM -0.225455141868911 0.379160986024888 no 2104 0.410812609310555 2979 6708665 A sedative which affects the nervous system.
SGTC_2551 apiole 73.87 µM -0.226277355490695 0.378853748585948 no 2105 0.410492854686851 2790 10659 A possible DNA adduct former.
SGTC_2584 androsterone 48.74 µM -0.226641794506616 0.378717592739082 no 2106 0.410351145253018 2932 2754130 A steroid.
SGTC_1062 mesoridazine 14.2 µM -0.226709556746029 0.378692278159454 no 2107 0.410324797693978 2787 4078 A neuroleptic.
SGTC_2320 7373003 200 µM -0.229421097029457 0.377679730637164 no 2108 0.409270820172087 2852 5415828
SGTC_1011 4112-3381 17.4 µM -0.22965196720622 0.37759355745016 no 2109 0.409181110956461 2976 2877139
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.230285243962494 0.377357215738276 no 2110 0.408935063061613 2991 551469
SGTC_678 1218-2179 85.9 µM -0.230388071978046 0.377318844195546 no 2111 0.408895114533868 2796 6820081 YOR116C RPO31
SGTC_1625 st003711 30.1 µM -0.233357953910129 0.376211120166565 no 2112 0.40774172991055 3027 24207034 YER133W GLC7
SGTC_3029 9088683 49.47 µM -0.23365860091674 0.37609903972399 no 2113 0.407625014889456 2962 25236615
SGTC_1416 3966-0321 25.3 µM -0.234641769397309 0.375732590009773 no 2114 0.407243393582499 2877 582530 YLR208W SEC13
SGTC_3056 9094900 49.47 µM -0.238098840601124 0.374444951093617 no 2115 0.405902216975216 2869 25236784
SGTC_914 3820-6779 408 µM -0.238460706596119 0.37431024922347 no 2116 0.405761893990369 2795 2893481
SGTC_2352 9027995 87.8 µM -0.239768615411091 0.373823518133936 no 2117 0.405254819302899 2889 2997347
SGTC_151 3013-0144 2.285 µM -0.240015884899905 0.373731520735474 no 2118 0.405158971062809 3045 906558 YHR107C CDC12
SGTC_252 miconazole 1.30953 nM -0.241419611358786 0.373209396330188 no 2119 0.404614957266135 2927 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1230 0170-0365 3.77 µM -0.241701545803427 0.373104557173225 no 2120 0.404505715847251 2936 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2398 5228213 48.84 µM -0.241721179669021 0.373097256542444 no 2121 0.404498108571028 3029 80771 YMR134W ERG29
SGTC_1399 3562-5772 25 µM -0.247203548796347 0.371060491181001 no 2122 0.402375349490585 2794 23847490
SGTC_261 5-fluorouridine 15.376 µM -0.247402850314706 0.370986515896186 no 2123 0.402298234254578 3059 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1511 0906-3109 28.5 µM -0.248034680565656 0.370752029275641 no 2124 0.402053786910125 2821 2882180
SGTC_616 4092-0450 108 µM -0.249079993639335 0.370364195171066 no 2125 0.401649452306998 2902 787165
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.250935446476745 0.369676106093366 no 2126 0.400932009333721 2858 641818 YHR062C RPP1
SGTC_3109 9122853 49.47 µM -0.253045313124256 0.36889417532163 no 2127 0.40011659877325 2895 1234709
SGTC_882 0843-0131 351 µM -0.253223235650841 0.36882826078818 no 2128 0.400047856028727 2836 5425421
SGTC_116 0155-0182 31.788 µM -0.254224239676065 0.368457493182938 no 2129 0.399661162539887 2874 771486
SGTC_451 chloral hydrate 100 µM -0.255022775787024 0.368161806606924 no 2130 0.399352754081889 2974 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1785 bathophenanthroline 24 µM -0.255311759127782 0.368054819414322 no 2131 0.399241159183184 2876 72812 An iron chelator.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.256160856232674 0.367740526565362 no 2132 0.398913316304712 2789 4000243
SGTC_844 0330-0132 15.3 µM -0.256308674245838 0.367685820848238 no 2133 0.398856249921106 2982 2828079
SGTC_1563 conessine 56.1 µM -0.258102466177294 0.3670221736846 no 2134 0.398163914158116 2984 441082 An anti-amoebic, histamine inhibitor.
SGTC_1224 0823-0416 294 µM -0.2605384929831 0.366121555819427 no 2135 0.397224213558583 2998 3598164
SGTC_206 4546-0025 72.014 µM -0.260860159783883 0.366002688109225 no 2136 0.39710017460935 2933 6620745 YIL048W NEO1
SGTC_1106 tegaserod maleate 11.7 µM -0.261604816421929 0.365727559464556 no 2137 0.396813065170688 2919 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_270 tamoxifen 5.46 µM -0.26289262879063 0.365251913852743 no 2138 0.396316668956995 3067 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1709 st033179 39.1045 µM -0.267157870307043 0.363678056172509 no 2139 0.394673806078697 2880 573381
SGTC_2733 amorolfine 100 µM -0.267201802945362 0.363661857108365 no 2140 0.394656894027647 2913 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1880 MG-132 525 µM -0.26756196423102 0.363529065812827 no 2141 0.394518255937071 3007 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2978 9011784 42.97 µM -0.268579462832286 0.363154003192979 no 2142 0.394126659028736 3006 2994934
SGTC_809 3998-0021 90 µM -0.270020623750731 0.362622997943429 no 2143 0.393572193637207 3052 715485
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.270095646079715 0.362595362695136 no 2144 0.393543335801506 3047 5377381
SGTC_2473 5854593 8.94 µM -0.270129815920619 0.362582776119231 no 2145 0.39353019233971 2847 2872951
SGTC_594 1487-1584 10.8 µM -0.270610828958396 0.362405609113132 no 2146 0.393345183098275 2904 5013332
SGTC_1155 4088-0394 48.2 µM -0.272130610850907 0.361846035920137 no 2147 0.39276079667038 2842 2326248
SGTC_226 1,3-diallylurea 8.28947 mM -0.273723332938518 0.361259923478137 no 2148 0.392148622619362 2983 74537 YKL182W FAS1
SGTC_2667 digitoxin 100 µM -0.274061464737147 0.361135534790369 no 2149 0.392018693548141 2975 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_853 0419-0306 21 µM -0.275102205826373 0.36075276911715 no 2150 0.391618858470138 2869 762713
SGTC_3002 9075603 71.4286 µM -0.275888108567266 0.360463820745658 no 2151 0.39131700379372 2882 20105405
SGTC_2898 9056270 58.44 µM -0.27590797060393 0.360456519215556 no 2152 0.391309375899601 2875 19154699
SGTC_674 0498-0004 451 µM -0.276002979838783 0.360421593350748 no 2153 0.391272888760315 2955 4231473
SGTC_1565 sinapyl alcohol 95.1 µM -0.276745896785133 0.360148533582569 no 2154 0.390987613571996 2977 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2720 fluspirilene 36.88 µM -0.277709964215502 0.359794296125698 no 2155 0.390617505514976 2981 3396 An atypical antipsychotic.
SGTC_1905 st060207 84.5 µM -0.278417157547716 0.359534521163298 no 2156 0.390346075086326 2844 1948547
SGTC_569 4130-2812 160 µM -0.278833694337411 0.359381544102576 no 2157 0.390186227594522 2897 743552
SGTC_1480 1070-0044 41.2 µM -0.281418292215869 0.358432830796239 no 2158 0.389194794824337 2984 3124987
SGTC_2121 5257820 149.641 µM -0.28158887338121 0.35837024721165 no 2159 0.389129386432968 3065 791256
SGTC_2829 7992743 58.44 µM -0.282086825042746 0.358187578234556 no 2160 0.3889384676385 3084 16462845
SGTC_304 1310-0298 97 µM -0.282641617393434 0.357984095999518 no 2161 0.388725787236433 2939 1550234
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.283328775752344 0.357732121564459 no 2162 0.388462410382434 3006 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3292 9120825 59.784 µM -0.284669688148923 0.357240600324854 no 2163 0.387948607769455 3059 24824900
SGTC_2572 astragaloside iv 100 µM -0.284885513413286 0.357161510098832 no 2164 0.387865927462856 3074 45006101 An anti-inflammatory agent.
SGTC_217 ketoconazole 989 nM -0.285760677888967 0.356840864715053 no 2165 0.387530713627084 2991 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1466 k213-0079 57.5 µM -0.288088937454472 0.35598832286029 no 2166 0.386639330228159 2911 3657981
SGTC_119 0121-0043 24.815 µM -0.288474168975614 0.35584733139717 no 2167 0.386491900323331 2924 1092378
SGTC_141 0443-0274 32.331 µM -0.289139419615648 0.355603901743876 no 2168 0.386237344377156 3050 1627241
SGTC_2391 6285546 200 µM -0.289476962234276 0.355480410082412 no 2169 0.386108203532534 2879 846083
SGTC_3206 9114350 49.47 µM -0.290242603416767 0.355200352662459 no 2170 0.385815322724599 3041 17087243
SGTC_74 000s-0487 160.283 µM -0.290618046328 0.355063051134517 no 2171 0.385671728275544 2881 677548
SGTC_1022 4477-0945 21.3 µM -0.291635198807199 0.35469116749828 no 2172 0.385282779992094 2920 4648966
SGTC_3233 9132340 49.47 µM -0.291870187785282 0.354605272269975 no 2173 0.385192939098316 2924 17682950
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.291967200523218 0.354569813480531 no 2174 0.385155851023172 3147 6728940
SGTC_1624 st003710 6.25 µM -0.292593512118356 0.354340922844841 no 2175 0.384916436716572 3075 24207033
SGTC_1924 st058459 75.1 µM -0.292604769471544 0.354336809235115 no 2176 0.384912133873989 2876 688683
SGTC_2105 5350118 200 µM -0.292982416275831 0.354198821143814 no 2177 0.384767796014777 2948 2133313
SGTC_988 1497-1057 103 µM -0.29410560163775 0.353788534447647 no 2178 0.384338605299941 2950 3533044
SGTC_60 0986-0278 202 µM -0.295702377828509 0.35320554276805 no 2179 0.383728690556184 2919 3110598
SGTC_3055 9094636 49.47 µM -0.29625540968738 0.35300370803713 no 2180 0.383517518060785 3100 25236176
SGTC_2214 7179297 48.276 µM -0.296364409904021 0.352963932150647 no 2181 0.383475900943544 2933 769744
SGTC_2765 myclobutanil 7.74 µM -0.296429114870992 0.352940321054611 no 2182 0.383451196727624 3029 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1867 st057372 64 µM -0.296611531811351 0.35287375944706 no 2183 0.383381552887035 2924 688837
SGTC_1322 1348-1070 12 µM -0.29674024105985 0.352826797798254 no 2184 0.383332416042645 3021 6758089
SGTC_3211 9128781 49.47 µM -0.297721756170486 0.352468749945011 no 2185 0.382957768496905 3041 17194361
SGTC_1368 1852-0141 284 µM -0.298064685842617 0.352343683086114 no 2186 0.382826896900108 3032 2838987
SGTC_2953 9074162 66.49 µM -0.298453257992152 0.352201989655016 no 2187 0.382678623017826 3054 16451992
SGTC_2068 5226020 147 µM -0.298547223512106 0.352167728063419 no 2188 0.38264276962595 2982 1810509
SGTC_2235 salicylic acid 500 µM -0.298777061643061 0.352083929825893 no 2189 0.382555077052913 2937 338 A COX inhibitor and kinase inhibitor.
SGTC_2345 9052315 157.45 µM -0.300002075510283 0.351637414988752 no 2190 0.382087786236961 3021 6469265
SGTC_162 k030-0015 37.8 µM -0.300943747261921 0.351294316775843 no 2191 0.381728695106054 3021 1809920 YMR134W ERG29
SGTC_963 1269-2853 151 µM -0.301157202542363 0.351216561153002 no 2192 0.381647311559459 2940 3668223
SGTC_1201 1889-3372 45.9 µM -0.301699124591998 0.351019182510087 no 2193 0.38144071783973 2965 5392199
SGTC_3121 9125696 49.47 µM -0.302411552630723 0.350759763391846 no 2194 0.381169174531165 2955 1235365
SGTC_570 0987-0065 62.6 µM -0.302679933489247 0.35066205488685 no 2195 0.381066895816213 2876 3104428
SGTC_992 3909-8734 162 µM -0.302768832559729 0.350629691882641 no 2196 0.381033018619417 2982 4288319
SGTC_1351 1496-0003 46.5 µM -0.302983106195917 0.35055169171398 no 2197 0.380951368081242 3067 3891978
SGTC_90 0870-0863 4.608 µM -0.304970182420748 0.349828654153612 no 2198 0.380194431085638 2908 1738164
SGTC_1968 st069590 43.6 µM -0.305990539133763 0.349457588202924 no 2199 0.379805924599177 3086 6384066
SGTC_1485 3909-9022 254 µM -0.306949126967656 0.349109116312336 no 2200 0.379441047439565 2986 714516
SGTC_3049 9092223 49.47 µM -0.309273981387184 0.348264499384474 no 2201 0.37855656063155 3048 8623917
SGTC_3260 9137109 49.47 µM -0.309478263657076 0.348190319751701 no 2202 0.378478872120305 3019 17478346
SGTC_1409 3909-8004 61.9 µM -0.31039441790286 0.347857714346375 no 2203 0.378130519268307 2985 2119279
SGTC_1615 st002656 86.5 µM -0.310987735629179 0.347642375616084 no 2204 0.377904972613772 2937 1584458
SGTC_2526 patulin 37.61 µM -0.311551137284895 0.347437940115583 no 2205 0.377690836915519 3101 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1825 st052143 62.6 µM -0.31192057281002 0.347303911101357 no 2206 0.37755044357294 3129 674173
SGTC_814 3342-0569 96 µM -0.317578975553882 0.34525347072603 no 2207 0.375402162102635 2983 4346283
SGTC_1127 asiatic acid 681.4 nM -0.319940580996756 0.344399031171833 no 2208 0.374506687106845 2952 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2614 arthonioic acid 13.39 µM -0.321195982806265 0.343945143824667 no 2209 0.374030938126242 2930 6710684
SGTC_2957 9076800 11.52 µM -0.322840390564493 0.343350952484237 no 2210 0.3734080611169 3009 16459615
SGTC_684 1140-0066 328 µM -0.323356103901641 0.343164683944849 no 2211 0.373212784660214 3034 6813534
SGTC_2432 5630864 12.22 µM -0.323702341199492 0.343039649184667 no 2212 0.373081699098176 3112 5714970
SGTC_921 1561-0023 372 µM -0.324809409574289 0.342639975083198 no 2213 0.372662661276915 2945 24050882
SGTC_681 1642-0006 26.6 µM -0.325851335076087 0.342263979717447 no 2214 0.372268418373631 3077 4446530
SGTC_851 0394-0702 453 µM -0.325874050047041 0.342255784399097 no 2215 0.372259824991047 3118 762646
SGTC_130 0136-0219 337.655 µM -0.325994864085145 0.342212197235917 no 2216 0.372214120465544 2931 234244
SGTC_3266 9136860 49.47 µM -0.326621288558511 0.341986230182632 no 2217 0.371977169982825 3079 4871271 YPR165W RHO1
SGTC_2395 5646831 180.19 µM -0.32789328731027 0.341527562439338 no 2218 0.371496174680816 3155 6808628
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.328290426161459 0.341384406742054 no 2219 0.371346041120753 3058 688664
SGTC_2934 9036370 36.88 µM -0.330100190774054 0.340732334395879 no 2220 0.370662129542935 3085 6462800
SGTC_635 k038-0028 24.7 µM -0.33235029990792 0.339922265904349 no 2221 0.369812381236662 3033 4035102
SGTC_2037 5169046 200 µM -0.33406745804079 0.339304563326658 no 2222 0.369164327750012 3102 5718022
SGTC_2887 9044784 58.44 µM -0.334317026977573 0.33921482333256 no 2223 0.369070171615124 3002 6465546
SGTC_3150 9097574 49.47 µM -0.334746882063522 0.339060277431776 no 2224 0.368908016433477 3161 17217476
SGTC_868 0527-0199 213 µM -0.334833299480566 0.339029211025656 no 2225 0.368875419816615 3017 2849450
SGTC_3221 9128209 49.47 µM -0.335001315681226 0.338968813608585 no 2226 0.368812046869322 3026 16460723
SGTC_2265 7929201 200 µM -0.33511913620706 0.338926462688736 no 2227 0.36876760903247 2943 1265108
SGTC_1082 camptothecin 424.86 nM -0.336741248060061 0.338343597167917 no 2228 0.368155983014019 2831 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_604 1000-0114 314 µM -0.338097645940663 0.337856506474344 no 2229 0.367644802233792 3146 1572745
SGTC_1188 1403-0014 4.57 µM -0.338306074244299 0.337781682644767 no 2230 0.367566273363567 3021 9614867
SGTC_1217 1183-1422 255 µM -0.33883741013531 0.337590966990373 no 2231 0.367366108683426 3138 2849664
SGTC_286 k060-0067 22.9 µM -0.339645971675894 0.337300825061511 no 2232 0.367061576804802 3043 5985051
SGTC_1122 capsaicin 818.572 nM -0.339840800537851 0.337230927680678 no 2233 0.366988210099724 3132 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2362 9071156 126 µM -0.340677088949386 0.336930962205361 no 2234 0.36667334417584 3154 653133
SGTC_2954 9074818 52.69 µM -0.341664043248543 0.336577088277551 no 2235 0.366301867347514 3174 16648742
SGTC_1223 0764-0573 147 µM -0.341928183675896 0.336482404864477 no 2236 0.366202469540006 3000 1609797
SGTC_1109 tnp00067 928.257 nM -0.341940376584928 0.336478034461422 no 2237 0.366197881483585 3031 676295
SGTC_1013 4112-3890 241 µM -0.342868032866295 0.336145591929442 no 2238 0.365848870849061 2965 705171
SGTC_2369 9071472 200 µM -0.343172766630539 0.336036412973716 no 2239 0.36573424555943 3148 17296037
SGTC_2274 7947094 46.08 µM -0.34424056792981 0.335653954030748 no 2240 0.365332687856608 3013 2971028
SGTC_3215 9129942 49.47 µM -0.34617980255466 0.334959805505139 no 2241 0.364603796315203 3147 17682944
SGTC_3081 9117243 49.47 µM -0.346309567897518 0.334913376121182 no 2242 0.364555039424286 3182 45595589
SGTC_1654 st012436 41.8 µM -0.3470984242174 0.334631181628655 no 2243 0.364258688646221 3107 4323132
SGTC_924 2046-0044 21.3 µM -0.348876938206538 0.33399530356431 no 2244 0.363590849667357 2986 3623589
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.349294585526998 0.333846049708381 no 2245 0.363434081453241 3123 616764
SGTC_157 1348-1695 65.819 µM -0.349460391310404 0.333786803287156 no 2246 0.363371850888414 3034 5380510
SGTC_892 0929-0076 29 µM -0.349528943944411 0.333762308981776 no 2247 0.363346122627475 3031 5751038
SGTC_2734 clemastine 41.6 µM -0.350559998080006 0.333393992086087 no 2248 0.362959235553252 3052 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2947 9072639 7.68 µM -0.351016595586328 0.333230935946566 no 2249 0.362787949066246 3102 16488146
SGTC_1852 st056254 31.4 µM -0.351750886322743 0.332968778513456 no 2250 0.362512547236771 3021 442583
SGTC_3069 9117009 49.47 µM -0.352715981799794 0.332624343015308 no 2251 0.36215068836705 3064 41904981
SGTC_715 0868-0130 184 µM -0.357436939100892 0.330941507906674 no 2252 0.360382363658713 3197 2876258
SGTC_1878 temozolomide 1 mM -0.357645199570843 0.330867349554672 no 2253 0.360304424133145 3158 5394 DNA alkylating agent.
SGTC_135 0933-0004 26.348 µM -0.358884643435745 0.330426140009794 no 2254 0.359840694082296 3149 21230617 YGL099W LSG1
SGTC_911 3456-4043 236 µM -0.360457885572479 0.329866446393037 no 2255 0.359252372626502 3118 914281
SGTC_2595 hexamethylquercetagetin 100 µM -0.360512893088827 0.329846883905033 no 2256 0.359231808328912 3093 386331
SGTC_2683 piperine 63.03 µM -0.360942012790615 0.32969429075859 no 2257 0.359071397979218 3054 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_118 0083-0097 135.343 µM -0.361499886415457 0.329495955642965 no 2258 0.35886289493822 3076 5207356
SGTC_1782 st039423 80.636 µM -0.363496718147495 0.328786435777429 no 2259 0.358116932026777 3071 2068169
SGTC_3294 9122953 26.2835 µM -0.364694477473344 0.328361140257583 no 2260 0.357669740723479 3034 16459826
SGTC_936 3005-4620 401 µM -0.365105770190813 0.328215151360024 no 2261 0.35751622690595 3239 777207
SGTC_3227 9130768 49.47 µM -0.36532374624097 0.328137791104861 no 2262 0.357434877319476 3057 17720899
SGTC_2806 7952793 58.44 µM -0.365343987121605 0.328130607938747 no 2263 0.357427323665604 3189 2972490
SGTC_2003 4023581 200 µM -0.367090558775943 0.327511017089207 no 2264 0.356775734726223 3179 16641307
SGTC_2112 5488546 200 µM -0.367736589690426 0.32728195982563 no 2265 0.356534827370773 3029 600757
SGTC_109 0132-0036 33.701 µM -0.367933541904279 0.327212141212779 no 2266 0.356461394528525 2994 67274 A color developer.
SGTC_2334 9017922 200 µM -0.372160649059975 0.325715112716772 no 2267 0.354886621316808 3177 3163164
SGTC_2066 5222451 176 µM -0.373390987531721 0.325279914954572 no 2268 0.35442873309464 3046 2281147
SGTC_645 0845-0943 5.41 µM -0.374613264482463 0.324847804551603 no 2269 0.353974053324422 3108 1885106
SGTC_533 1222-0222 6.71 µM -0.376371782294847 0.324226530773598 no 2270 0.353320260434177 3226 3982874
SGTC_1594 piperine 70.1 µM -0.377232814610235 0.323922511480499 no 2271 0.353000298033711 3052 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_257 daunorubicin 18.5 µM -0.377604797046357 0.323791205637517 no 2272 0.35286210028477 3162 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2383 9036125 200 µM -0.378630036007555 0.323429420735844 no 2273 0.352481307240674 3058 79580
SGTC_2883 9059145 45.46 µM -0.378636325999349 0.323427201646973 no 2274 0.352478971475138 3011 16476510
SGTC_2046 4110841 106 µM -0.379405832530978 0.323155769623224 no 2275 0.352193260021607 3234 44119630 YMR134W ERG29
SGTC_3003 9075612 71.4286 µM -0.382580490180698 0.322036952705944 no 2276 0.351015419125963 3142 6501993
SGTC_3048 9093155 49.47 µM -0.384046244236897 0.321520932740098 no 2277 0.350472086379583 3200 25236002
SGTC_816 0325-0417 81.3 µM -0.385039438541908 0.321171473404019 no 2278 0.350104098076348 3140 68101
SGTC_3071 9117417 49.47 µM -0.386527264655925 0.320648272152613 no 2279 0.349553107150332 3095 45595590 YGL055W OLE1
SGTC_231 b-estradiol 524 µM -0.389354781567036 0.319654944237815 no 2280 0.348506858581377 3079 450 A steroid.
SGTC_50 0929-0078 56.389 µM -0.389451830193504 0.319620873226617 no 2281 0.348470968672872 3059 1377751
SGTC_1273 0849-0096 14.1 µM -0.39060399889022 0.319216495968426 no 2282 0.348044984666647 3142 5286025
SGTC_2028 5153890 36.43 µM -0.392900691256419 0.318411066374022 no 2283 0.347196415501459 3104 2830968 YPR165W RHO1
SGTC_1267 0828-0272 9.49 µM -0.393632494065416 0.318154609598915 no 2284 0.346926193666523 3248 745334
SGTC_364 0083-0097 67.7 µM -0.394307654636045 0.317918080113476 no 2285 0.346676956283946 3213 5207356
SGTC_692 k241-0027 77.8 µM -0.394429229052305 0.317875496748888 no 2286 0.346632083799554 3263 3600480
SGTC_1001 4048-4355 44.4 µM -0.395720116769038 0.317423491524383 no 2287 0.346155756690169 3064 21824233
SGTC_2788 5282734 71.43 µM -0.397407610103445 0.316833024977224 no 2288 0.345533452272387 3253 743706
SGTC_846 0335-0850 148 µM -0.397565124135658 0.316777933408893 no 2289 0.345475386387764 3177 6819598
SGTC_1737 st035557 69.7 µM -0.399128197106217 0.316231458735322 no 2290 0.344899373309542 3135 5716916
SGTC_1455 4262-0120 131 µM -0.399973726713483 0.31593601551026 no 2291 0.344587934107429 3271 1529587
SGTC_219 mitoxanthrone 164.414 µM -0.400719993113151 0.315675354265494 no 2292 0.344313144625635 3130 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2945 9067681 61.76 µM -0.400764925228281 0.315659662980586 no 2293 0.344296602387358 3169 16456930
SGTC_2556 citropten 84.59 µM -0.400860460489906 0.315626301066045 no 2294 0.344261431050041 3128 2775 A potential DNA crosslinker.
SGTC_2759 disulfiram 3.38 µM -0.401154107081066 0.31552376600649 no 2295 0.344153333396683 3059 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2869 9037858 32.47 µM -0.401719389539757 0.315326421545878 no 2296 0.343945276567983 3065 27187042
SGTC_1940 st075990 51.1 µM -0.402952741130312 0.314896031906079 no 2297 0.34349149549123 3355 1084979
SGTC_717 1532-0246 73.2 µM -0.403346248120544 0.314758766782839 no 2298 0.343346761786357 3167 9561992
SGTC_1031 k035-0009 16 µM -0.40462231754681 0.314313817836521 no 2299 0.342877575620714 3268 5180959
SGTC_2291 7917025 104.35 µM -0.404735762891432 0.314274273951866 no 2300 0.342835875664478 3057 2964612
SGTC_3345 9148410 3.559 µM -0.408031349033384 0.31312645637238 no 2301 0.341625329864641 3235 4903596
SGTC_416 estradiol valerate 100 µM -0.4100958652659 0.312408327814408 no 2302 0.34086781284178 3179 13791 A steroid.
SGTC_1555 citronellol 128 µM -0.410542298578048 0.31225313240766 no 2303 0.340704090718966 3204 8842 A terpine precursor.
SGTC_2822 7994718 71.43 µM -0.411306570555716 0.311987522793511 no 2304 0.340423876124445 3148 1018011
SGTC_1553 gossypol 38.6 µM -0.412662358579934 0.311516582440154 no 2305 0.339927003385106 3125 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1690 st023502 41.2 µM -0.412948597043375 0.311417195327821 no 2306 0.339822137470077 3215 24207482
SGTC_2488 5268135 45.7 µM -0.414908604281143 0.310737015288684 no 2307 0.339104405401484 3247 1270356 YLR208W SEC13
SGTC_1838 st055369 84.5 µM -0.415859861132457 0.310407134049355 no 2308 0.338756276256645 3175 676036
SGTC_442 cape 100 µM -0.416327180167391 0.310245130822437 no 2309 0.338585303071353 3259 5281787
SGTC_1169 aniline yellow 25.8 µM -0.416515543102526 0.310179842364415 no 2310 0.338516398074532 3143 6051 A DNA damaging agent.
SGTC_3183 9108214 49.47 µM -0.416966363853539 0.310023607727294 no 2311 0.33835150540719 3209 4974831
SGTC_2757 clomiphene 4.22 µM -0.417419538251786 0.309866591982523 no 2312 0.338185783103698 3332 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_345 1362-0200 395 µM -0.41789107342327 0.309703251414472 no 2313 0.338013379687069 3149 1419823
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.418297774143964 0.309562399783235 no 2314 0.337864708425175 3259 1377
SGTC_3261 9137475 49.47 µM -0.419758005569764 0.309056912107184 no 2315 0.337331122871841 3166 17027690
SGTC_1828 st055811 49 µM -0.421288610072892 0.308527451253272 no 2316 0.336772173166433 3252 5877589
SGTC_1906 st060206 94.7 µM -0.421368998252075 0.30849965467041 no 2317 0.336742826773914 3262 5133468
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.42156172160667 0.308433019358974 no 2318 0.336672475513098 3262 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1473 k844-0725 134 µM -0.423703621620913 0.307692869139742 no 2319 0.3358909868107 3212 54682906
SGTC_3285 9112818 20.8695 µM -0.423755565144657 0.307674929351418 no 2320 0.335872043608787 3148 17017947 YPR165W RHO1
SGTC_1114 scopoletin 1.73284 µM -0.42436628892335 0.307464037548615 no 2321 0.335649350997601 3262 5280460 A coumarin with genotoxic properties.
SGTC_2490 carminic acid 95.39 µM -0.425014446006568 0.307240289079121 no 2322 0.33541307193439 3240 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2311 7694451 200 µM -0.425446793560483 0.307091079484757 no 2323 0.335255500216209 3178 2163142
SGTC_1676 st018489 23.4 µM -0.426356552055059 0.306777212580975 no 2324 0.334924027833914 3148 3696235
SGTC_3342 9147791 14.508 µM -0.426457354649315 0.306742444371739 no 2325 0.33488730810756 3148 1838168
SGTC_382 3229-0966 23.2 µM -0.427682692717349 0.306319947419919 no 2326 0.33444107607376 3299 5722370
SGTC_269 exalamide 29 µM -0.428014430858946 0.306205608255925 no 2327 0.334320307005567 3155 3316 A derivative of salicylamide.
SGTC_3087 9117406 49.47 µM -0.428385685522776 0.306077671433369 no 2328 0.334185172304085 3252 42546093
SGTC_661 1304-0007 33.6 µM -0.429076633219054 0.305839629244187 no 2329 0.333933728285371 3193 3117130
SGTC_2413 inermin 26.06 µM -0.429390602531304 0.305731489041254 no 2330 0.33381949577185 3379 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1749 st037932 54.2 µM -0.430747292284752 0.305264400291421 no 2331 0.333326063918232 3264 594497
SGTC_859 0439-0102 54.6 µM -0.431603215225144 0.304969881334832 no 2332 0.333014910610569 3288 610143
SGTC_280 3448-3607 3.04 µM -0.434110491391 0.304107867051707 no 2333 0.332104103650198 3269 626179
SGTC_1222 0366-0074 1.18 µM -0.434958846632556 0.303816444251643 no 2334 0.331796149558731 3296 286520
SGTC_2651 TUB2.036 5 µM -0.435424319925724 0.303656600117003 no 2335 0.331627230387274 3331 15992207 YFL037W TUB2
SGTC_2638 epoxomicin 18 µM -0.436437969817063 0.303308641383651 no 2336 0.33125949769288 3270 9915668 A protesome inhibitor.
SGTC_1777 st045864 34.765 µM -0.436480703405076 0.303293976008452 no 2337 0.331243998339494 3251 4691462
SGTC_325 2810-4341 181 µM -0.436590182083164 0.303256406401908 no 2338 0.331204292046865 3279 774970
SGTC_2130 NSC 7 2.4545 µM -0.43680525288458 0.303182606989945 no 2339 0.331126294583919 3268 21448
SGTC_322 k048-0136 19.3 µM -0.436889815852932 0.303153592246054 no 2340 0.331095629029252 3248 6823282
SGTC_2608 thymoquinone 42.66 µM -0.436921875351763 0.303142592505717 no 2341 0.331084003405308 3258 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2877 9040724 71.43 µM -0.437356513020417 0.302993484227509 no 2342 0.330926408340659 3331 6463895
SGTC_2859 9028643 45.46 µM -0.43829680120396 0.302671018124401 no 2343 0.330585572228348 3202 17151580
SGTC_2532 xanthone 78.9 µM -0.44042132907667 0.301942991065255 no 2344 0.329815989851412 3257 7020 An insecticide.
SGTC_2127 5253358 187.912 µM -0.440759728338626 0.30182710205539 no 2345 0.329693475533668 3113 20612
SGTC_3325 9138760 55.175 µM -0.440808257589103 0.301810484252852 no 2346 0.329675907465927 3176 43844959
SGTC_1881 5652484 16 µM -0.443300933603121 0.300957474408191 no 2347 0.32877404030046 3284 2255129
SGTC_1722 st034304 3.6505 µM -0.443642947203504 0.300840519997232 no 2348 0.328650375054535 3183 4036148 YLR033W RSC58
SGTC_3306 9127676 59.7925 µM -0.443826184116301 0.300777869037786 no 2349 0.328584127986733 3247 41905287
SGTC_1386 3228-0095 33.8 µM -0.44587131588756 0.30007901316131 no 2350 0.327845101601674 3306 870181
SGTC_26 0302-0163 425.158 µM -0.447906799949311 0.299384184307713 no 2351 0.327110230324067 3236 3100915
SGTC_1044 1222-0021 1.78 µM -0.448241911083791 0.29926986140872 no 2352 0.326989309211521 3241 4306703
SGTC_1944 st076371 56.9 µM -0.448722133744003 0.299106068363401 no 2353 0.32681605788951 3167 24208455
SGTC_1522 st012842 45.6 µM -0.449125076804593 0.298968665041242 no 2354 0.326670715753342 3117 3491067 YOR116C RPO31
SGTC_33 0986-0033 35.816 µM -0.449223774520867 0.298935013555484 no 2355 0.326635119355723 3254 2848082
SGTC_751 0833-0568 350 µM -0.449562810903418 0.298819430493633 no 2356 0.326512854245468 3265 6954252
SGTC_2908 7930301 100 µM -0.451252463885423 0.298243703137532 no 2357 0.325903800629737 3188 2223178
SGTC_3005 9076496 71.4286 µM -0.452712005576445 0.297746790220082 no 2358 0.325378066735058 3288 21368410
SGTC_997 3996-0078 137 µM -0.453395578413157 0.297514192192718 no 2359 0.325131959883659 3232 735687
SGTC_2326 6164455 177.58 µM -0.453841045189383 0.297362658723136 no 2360 0.324971619437758 3232 2888790
SGTC_3149 9097855 49.47 µM -0.455145252275994 0.296919212274081 no 2361 0.324502372130024 3315 25236625 YMR079W SEC14
SGTC_1378 2093-0007 380 nM -0.457681611362049 0.296057686561922 no 2362 0.323590600507155 3295 3618014
SGTC_920 mycophenolic acid 780.421 nM -0.457953176243675 0.295965512088153 no 2363 0.323493040839493 3203 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.45840140307933 0.295813403892082 no 2364 0.323332041915827 3322 756377
SGTC_2117 5521686 200 µM -0.459012635842063 0.295606036649608 no 2365 0.323112546086836 3185 803312
SGTC_555 4296-0685 37 µM -0.459787201290371 0.295343353089291 no 2366 0.322834485378622 3269 2908540 YHR072W ERG7
SGTC_225 nsc-122657 1.016 µM -0.461196895273137 0.294865549976492 no 2367 0.322328674488444 3291 275685
SGTC_1907 st060210 83.7 µM -0.461774552075952 0.294669861355246 no 2368 0.322121500939057 3354 688793
SGTC_768 0384-0033 77.3 µM -0.462899858749694 0.294288821450109 no 2369 0.321718074382196 3210 3965305 YMR134W ERG29
SGTC_1420 4'-methoxyflavone 42 µM -0.46482305687615 0.293638135010879 no 2370 0.321029087391105 3300 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_333 3486-0131 40.1 µM -0.465480349239322 0.293415902395367 no 2371 0.320793753030032 3361 6744690
SGTC_357 1325-0123 420 µM -0.466832424148841 0.292959006785722 no 2372 0.320309887914836 3315 1098503
SGTC_2269 7935389 174.42 µM -0.467294135067101 0.292803060245126 no 2373 0.320144725985352 3278 97605
SGTC_1818 st052136 56.3 µM -0.467331623624438 0.292790399878156 no 2374 0.320131317247783 3315 674169
SGTC_1439 4092-1168 46 µM -0.467486074346967 0.292738242567686 no 2375 0.320076076489948 3284 2886240
SGTC_642 0335-0876 158 µM -0.467891519923711 0.292601345964019 no 2376 0.319931084034773 3263 6812350
SGTC_573 3702-0553 84.7 µM -0.468476663707868 0.292403827645528 no 2377 0.319721877726572 3241 1222756
SGTC_3092 9117248 49.47 µM -0.468719880463443 0.292321746810818 no 2378 0.319634937368987 3302 17141857
SGTC_2786 7743617 45.45 µM -0.469712947895479 0.29198671748293 no 2379 0.319280057980073 3221 583674
SGTC_2181 6316240 54.2555 µM -0.470936780694314 0.291574081370536 no 2380 0.318842940701684 3297 12779990
SGTC_2504 purpurogallin 52.29 µM -0.471028372407729 0.291543210600627 no 2381 0.318810236944317 3199 5281571 An antioxidant.
SGTC_3328 9140624 29.0385 µM -0.471276144826555 0.291459707133696 no 2382 0.318721774341273 3340 4904392
SGTC_3042 9091578 49.47 µM -0.476359131117154 0.2897491227444 no 2383 0.316909272730814 3325 25236497
SGTC_1757 st041620 31.8375 µM -0.478482236090096 0.289036028735314 no 2384 0.316153507358996 3308 5289815
SGTC_323 4013-0906 34.3 µM -0.479665793150969 0.288638862366355 no 2385 0.315732527451223 3325 2910086
SGTC_1504 k297-0033 30 µM -0.481374262873045 0.288066004779615 no 2386 0.315125262630389 3169 4388117
SGTC_1094 duloxetine 25.4 µM -0.482535247818559 0.287677027761315 no 2387 0.314712882634099 3236 60834 A selective serotonin reuptake inhibitor.
SGTC_3169 9102970 49.47 µM -0.484201725123826 0.287119124556201 no 2388 0.31412135635477 3343 17027839
SGTC_1652 st011932 78 µM -0.484681914815582 0.286958461794556 no 2389 0.313950998587679 3316 1551076
SGTC_1526 st051518 75 µM -0.485336153879068 0.286739633836285 no 2390 0.31371895681813 3249 673993
SGTC_2081 5214970 32.255 µM -0.486492607852868 0.286353020138718 no 2391 0.313308972580357 3335 2063512
SGTC_1210 3013-0140 750 nM -0.486684782006882 0.286288798453026 no 2392 0.313240865634722 3353 905973
SGTC_1445 4239-0156 97.7 µM -0.487596311153524 0.285984272432026 no 2393 0.312917904479182 3414 4008346
SGTC_1753 st043925 64 µM -0.488361979179358 0.285728595106691 no 2394 0.312646733832763 3336 670181
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.488446022118212 0.285700537513448 no 2395 0.312616975175869 3266 5106787 A p450 inhibitor.
SGTC_2076 5212012 200 µM -0.488603641406384 0.285647920114796 no 2396 0.312561167257409 3281 604802
SGTC_2157 5649910 96.377 µM -0.489774943137412 0.28525705379623 no 2397 0.312146581709526 3237 2858091
SGTC_2710 st078562 53.7235 µM -0.491422441252329 0.28470771122796 no 2398 0.311563847626087 3276 17250908
SGTC_2848 9016370 25.97 µM -0.493302214124345 0.284081536311333 no 2399 0.310899532077638 3414 7894410
SGTC_1347 1493-0251 600 nM -0.494079919138631 0.283822666217607 no 2400 0.310624869513053 3374 3986378
SGTC_2725 haloperidol 53.21 µM -0.494236423013872 0.283770585346302 no 2401 0.310569609691592 3262 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2115 tiliquinol 12.7705 µM -0.494895141611376 0.283551429203715 no 2402 0.310337070163119 3304 71208 A bioactive hydroxyquinoline.
SGTC_1092 toremifene 6.32 µM -0.497176078154612 0.282793187276772 no 2403 0.3095324445902 3314 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_29 0299-0004 12.984 µM -0.497611690607442 0.282648489349706 no 2404 0.309378881099585 3293 16871 A napthoquinone isolated from Swertia calycina.
SGTC_531 3788-1495 174 µM -0.497650380165448 0.28263563951212 no 2405 0.309365243742279 3218 2896655
SGTC_171 k064-0041 9.68 µM -0.498250023457894 0.282436517834961 no 2406 0.309153914095867 3270 53325
SGTC_1805 st050013 60.3 µM -0.498950895023996 0.282203867150408 no 2407 0.30890698903398 3297 4037144
SGTC_2776 terbinafine 19.92 µM -0.498992269761856 0.282190135904399 no 2408 0.308892414938878 3348 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_399 oxolinic acid 75 µM -0.499079430793944 0.282161210378961 no 2409 0.308861713779214 3266 4628 A DNA gyrase inhibitor.
SGTC_1871 st057448 67.3 µM -0.499226009523751 0.282112569534114 no 2410 0.308810086642682 3467 691747
SGTC_3210 9128157 49.47 µM -0.499301267699259 0.28208759734802 no 2411 0.308783581098685 3281 17590849
SGTC_1775 st081588 35.1725 µM -0.499582037780822 0.281994441544991 no 2412 0.308684704103829 3394 1426443 YGL099W LSG1
SGTC_320 4092-0846 5.34 µM -0.50041747403504 0.281717342505915 no 2413 0.308390575936515 3326 1359356
SGTC_1736 st036774 51 µM -0.500582376629812 0.281662662824944 no 2414 0.308332533968045 3458 1272247
SGTC_353 1988-1175 58.3 µM -0.501035657349122 0.281512386860688 no 2415 0.308173014136913 3217 2788357
SGTC_2401 5128683 200 µM -0.502504409999311 0.281025717805538 no 2416 0.307656375536251 3282 708373
SGTC_199 4063-0024 41.6 µM -0.503170137632417 0.280805263889367 no 2417 0.307422329128686 3376 306215
SGTC_3065 9113888 49.47 µM -0.506102647025977 0.279835167980221 no 2418 0.306392296211365 3458 16648368
SGTC_2170 morpholine 200 µM -0.507843743565622 0.279259970440714 no 2419 0.305781464889868 3385 121171 Reacts with secondary amines.
SGTC_2857 9024691 58.44 µM -0.50827652258597 0.279117084565099 no 2420 0.305629716144263 3364 16478292
SGTC_1742 st038235 28.8875 µM -0.509959168138381 0.27856188204608 no 2421 0.305040034115955 3358 564103 YBR002C RER2
SGTC_1197 1601-0112 267 µM -0.511198952451382 0.27815314965023 no 2422 0.304605876068096 3283 7350313
SGTC_3220 9131269 49.47 µM -0.512574680067426 0.277699942070264 no 2423 0.304124434245924 3405 17722206
SGTC_1658 st012944 20 µM -0.512878648800444 0.277599853960579 no 2424 0.304018104827943 3359 24207260
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.514288674887719 0.277135803800093 no 2425 0.303525089235229 3417 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1616 st002734 56.1 µM -0.514719365025594 0.276994136160149 no 2426 0.303374569657285 3268 4026101
SGTC_935 2996-0153 430 µM -0.515825033685594 0.276630609093773 no 2427 0.302988308288017 3419 23738523
SGTC_249 wiskostatin 11.211 µM -0.516515784842336 0.276403619333304 no 2428 0.302747108606382 3410 2775510 A n-wasp and actin depolymerizer.
SGTC_680 0417-1641 114 µM -0.517975858087162 0.27592412121811 no 2429 0.302237556731397 3247 2835990
SGTC_2673 kobusone 100 µM -0.517984548528488 0.275921268440975 no 2430 0.302234525001302 3405 6710676 An epoxy ketone and protein crosslinker.
SGTC_2831 7999036 19.48 µM -0.518581064814185 0.275725487011732 no 2431 0.302026458142342 3437 2988270
SGTC_952 1185-0122 232 µM -0.519370899676438 0.275466361979093 no 2432 0.301751060148645 3349 678600
SGTC_733 4069-0007 56.1 µM -0.522635906492736 0.274396467894603 no 2433 0.300613824190048 3429 5717425 YNL287W SEC21
SGTC_1337 1486-1011 40.3 µM -0.525738016377355 0.273381856478511 no 2434 0.29953512303987 3408 X1337
SGTC_1140 3229-1848 2.98 µM -0.526256219110907 0.273212548446521 no 2435 0.299355098798164 3409 2849525
SGTC_644 1498-1197 63.3 µM -0.527460953580081 0.2728191365429 no 2436 0.298936762394538 3432 6741615
SGTC_1460 k062-0059 9.15 µM -0.528377614431828 0.272519984849267 no 2437 0.298618635731552 3305 1373085
SGTC_1916 st067606 49.2 µM -0.52892344188533 0.27234193179926 no 2438 0.298429279763219 3359 19590279
SGTC_798 1287-0182 476 µM -0.529210857230743 0.272248197970052 no 2439 0.298329592909879 3447 1649755
SGTC_849 0386-0493 241 µM -0.53002597437598 0.271982453709221 no 2440 0.298046960979123 3332 726119
SGTC_1969 st069479 40.1 µM -0.531116987138057 0.271626964054581 no 2441 0.297668856685573 3426 3895485
SGTC_3223 9129970 49.47 µM -0.53218633011244 0.271278759805729 no 2442 0.297298474878061 3363 17248386
SGTC_1320 1313-0481 95.3 µM -0.53326320291677 0.270928328647994 no 2443 0.296925697961383 3465 6813365 YLR208W SEC13
SGTC_1293 1000-1278 195 µM -0.533384549522645 0.270888854740356 no 2444 0.296883705284214 3465 678847
SGTC_658 3253-0951 102 µM -0.534532835498385 0.27051546081117 no 2445 0.296486469055404 3383 1184878
SGTC_1604 st002052 72.4 µM -0.534775752076525 0.270436503371029 no 2446 0.29640246610327 3463 6254834 YHR062C RPP1
SGTC_1172 0370-0043 85 µM -0.536355843189384 0.269923192894136 no 2447 0.29585632147832 3442 376585
SGTC_1675 st018485 24.5 µM -0.536871575464757 0.26975575705462 no 2448 0.295678163244929 3349 3323024
SGTC_2348 9022543 33.42 µM -0.536962030672466 0.269726395545025 no 2449 0.295646920836212 3428 3162678 YDL140C RPO21
SGTC_1084 voriconazole 435 nM -0.537549299521735 0.269535808642646 no 2450 0.295444120414274 3437 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2136 5328288 199.296 µM -0.538119372994257 0.269350866744968 no 2451 0.29524731926543 3325 262395
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.538613834496695 0.269190506250523 no 2452 0.295076669814796 3456 7104
SGTC_3151 9099821 49.47 µM -0.538732289619334 0.269152096778643 no 2453 0.295035795113992 3406 17174189
SGTC_2027 5150920 200 µM -0.53937901536901 0.268942442278364 no 2454 0.29481267878706 3365 786715
SGTC_2641 levomentholum 100 µM -0.539893573109175 0.268775692375566 no 2455 0.294635215177966 3395 16666
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.540310637842499 0.268640574611887 no 2456 0.294491411680745 3473 1273210
SGTC_3267 9137951 49.47 µM -0.540888451720486 0.268453434865765 no 2457 0.294292235586437 3348 16643986
SGTC_918 glabranin 770.725 nM -0.54259305369801 0.267901738271785 no 2458 0.293705011334234 3389 124049 Also referred to as licorice root.
SGTC_456 gingerol 170 µM -0.543247273033238 0.267690151091114 no 2459 0.293479781138237 3500 442793 A herb.
SGTC_2836 9010338 19.48 µM -0.54704338047795 0.26646408101986 no 2460 0.292174464669409 3323 2994051
SGTC_2670 beta-carotene 100 µM -0.548636069172025 0.265950520300476 no 2461 0.291627613828006 3421 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1156 4092-0367 4.88 µM -0.548924953383717 0.265857423659915 no 2462 0.291528476365636 3388 1357585
SGTC_1262 0737-0114 49.6 µM -0.550660016730828 0.265298624948492 no 2463 0.290933379201085 3497 765919
SGTC_2889 9059656 51.95 µM -0.551161215890326 0.265137318593008 no 2464 0.290761582165912 3440 3949838
SGTC_1633 st005664 67.9 µM -0.551281898957618 0.265098485296347 no 2465 0.290720222477592 3373 2063822
SGTC_1573 oleylamine 1.06 µM -0.551983518009892 0.264872776139541 no 2466 0.290479822832546 3452 5356789 An amine of the fatty acid oleic acid.
SGTC_2014 4013930 200 µM -0.552379521219705 0.264745425999775 no 2467 0.29034417913678 3467 64556
SGTC_496 calpeptin 138 µM -0.552414440482491 0.264734197854918 no 2468 0.290332219601713 3409 73364 A calpain inhibitor.
SGTC_1768 st044301 37.178 µM -0.553019360377558 0.264539726797677 no 2469 0.290125076573004 3383 3931349
SGTC_1243 0416-0003 5.65 µM -0.553925598079972 0.264248523460378 no 2470 0.289814882796791 3357 2141977
SGTC_1991 st073000 8.92 µM -0.554612576125921 0.264027884131857 no 2471 0.289579842569837 3536 4301969 YIL048W NEO1
SGTC_3157 9099274 49.47 µM -0.55465446997535 0.264014431963956 no 2472 0.289565512052845 3469 17217662
SGTC_3182 9108849 49.47 µM -0.555338689230748 0.263794777743247 no 2473 0.289331510145424 3481 17133045
SGTC_1638 st008370 60.6 µM -0.555597909851006 0.263711584754607 no 2474 0.289242880317101 3452 24207134
SGTC_113 0099-0221 2.5 µM -0.5558379038347 0.2636345741998 no 2475 0.289160835625015 3510 89219
SGTC_866 0495-0101 262 µM -0.556399285136016 0.263454479979692 no 2476 0.288968963742968 3331 635694
SGTC_580 1123-0028 41 µM -0.556875789455472 0.263301664052997 no 2477 0.288806148582204 3496 1677248 YPR107C YTH1
SGTC_690 glyoxal 20.3 µM -0.557058314317101 0.263243139943046 no 2478 0.288743793716399 3406 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2202 7226349 200 µM -0.557404143898006 0.263132272622998 no 2479 0.288625667432471 3366 844334
SGTC_2692 st077426 47.7 µM -0.557545610180159 0.263086927718068 no 2480 0.288577352834666 3472 25238571
SGTC_2241 6772625 37.8075 µM -0.557919077920537 0.262967237397689 no 2481 0.288449821715247 3437 2285411
SGTC_2221 6807166 181.081 µM -0.559337361509276 0.262512954347722 no 2482 0.287965750834237 3418 674925
SGTC_1698 5-fluorocytosine 1.055 µM -0.559980878266201 0.262306965403222 no 2483 0.287746240270726 3477 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_76 0433-0009 400.328 µM -0.561436397433264 0.261841361041988 no 2484 0.287250038693527 3443 2841569
SGTC_318 1488-0629 67.2 µM -0.561704593637466 0.26175561433776 no 2485 0.287158652028414 3455 3662576
SGTC_564 3555-0129 330 µM -0.563255679907968 0.261259989471457 no 2486 0.28663039644279 3423 563260
SGTC_2406 ethylparaben 405.7 µM -0.563301150330012 0.261245467401468 no 2487 0.286614917474316 3214 8434 A possible steroid mimic.
SGTC_1046 2001-0062 216 µM -0.564028170600762 0.261013332380637 no 2488 0.286367480255886 3417 739778
SGTC_1153 4055-0057 267 µM -0.564091959922366 0.260992969736116 no 2489 0.28634577476225 3376 882706
SGTC_3313 9133968 57.047 µM -0.565536622020799 0.260532027661387 no 2490 0.285854411081691 3443 1494643
SGTC_1897 st060201 15 µM -0.565749971206775 0.260463990799594 no 2491 0.285781879977717 3422 611878
SGTC_1832 st054113 55 µM -0.566820964218815 0.26012259040622 no 2492 0.285417912919339 3466 1251267
SGTC_1152 3909-8331 15.9 µM -0.567519789414166 0.259899950361902 no 2493 0.285180542714629 3412 16001939
SGTC_2659 sanguinarine 24.21 µM -0.567680461268074 0.259848775512904 no 2494 0.285125980553357 3400 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1761 st044296 37 µM -0.568212966984908 0.259679206753453 no 2495 0.284945183824152 3439 1826700
SGTC_3216 9129716 49.47 µM -0.570065432458963 0.259089761131937 no 2496 0.284316659722428 3397 8056934
SGTC_629 3448-6466 76.7 µM -0.570544043169498 0.258937582038984 no 2497 0.284154379393138 3482 573744
SGTC_1326 1431-2094 10.8 µM -0.572066358688056 0.258453854098223 no 2498 0.283638509593369 3415 616278
SGTC_3307 9126885 69.2785 µM -0.572571176817429 0.258293547513479 no 2499 0.283467540072814 3405 24824909
SGTC_1628 st004252 77.7 µM -0.573050403236475 0.258141415348974 no 2500 0.283305283553309 3479 692968
SGTC_185 k048-0037 25.491 µM -0.574321917767947 0.257737993729041 no 2501 0.282874990055186 3499 6827589
SGTC_1358 1509-0022 2.48 µM -0.574403383352593 0.257712157777606 no 2502 0.282847431971916 3478 3258434
SGTC_3176 9106582 49.47 µM -0.576046716481609 0.257191279242214 no 2503 0.282291802687893 3405 17018027
SGTC_2402 5553605 200 µM -0.577670431064776 0.256677157204471 no 2504 0.28174332300247 3535 6758546
SGTC_2436 5633522 8.09 µM -0.578033490358088 0.256562273804371 no 2505 0.281620754364593 3514 5724242
SGTC_1271 0832-2808 169 µM -0.578256817427241 0.256491619389295 no 2506 0.281545372032085 3518 3663794
SGTC_490 phenamil 164 µM -0.578926552288692 0.25627979487741 no 2507 0.281319366564835 3424 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2564 betulinic acid 100 µM -0.580261175270688 0.255857950870714 no 2508 0.2808692525061 3555 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_746 1095-0025 46.6 µM -0.581025852419433 0.255616417199536 no 2509 0.280611514980994 3522 6749286
SGTC_2007 4011539 71.82 µM -0.581216533695407 0.255556206482057 no 2510 0.280547262915739 3484 45595301
SGTC_3028 9087778 49.47 µM -0.583246593516989 0.254915641628227 no 2511 0.279863654612969 3403 17217395
SGTC_2312 7706453 155.7 µM -0.585340732525231 0.254255738758673 no 2512 0.27915931575167 3459 976098
SGTC_2404 5161160 200 µM -0.586222908563326 0.253978016747393 no 2513 0.278862864467899 3479 2831543
SGTC_588 3970-1144 52.9 µM -0.587231051235407 0.253660833585305 no 2514 0.278524270334692 3465 1888707
SGTC_1015 4130-4525 82 µM -0.58835878033983 0.253306272657862 no 2515 0.27814574945027 3406 1363237
SGTC_376 3970-0862 59.1 µM -0.589415646478692 0.252974227884611 no 2516 0.277791241526858 3489 3135186
SGTC_2430 5571206 200 µM -0.589576733623442 0.25292363786672 no 2517 0.277737226943228 3545 1731771
SGTC_2824 7998404 51.95 µM -0.590162463240613 0.252739732186741 no 2518 0.277540867541013 3448 837851
SGTC_3355 9151058 44.0485 µM -0.590560248893155 0.252614876765083 no 2519 0.277407552974699 3518 17015728
SGTC_2915 7971052 15.16 µM -0.590826857859195 0.252531212763209 no 2520 0.277318218714594 3414 5741558
SGTC_2872 9044037 25.97 µM -0.590984856491444 0.252481638433371 no 2521 0.277265283808255 3475 6465195
SGTC_3247 9135149 49.47 µM -0.591656797468593 0.252270864639058 no 2522 0.277040215983667 3477 8934436 YOR116C RPO31
SGTC_1256 0570-0116 285 µM -0.592790586384774 0.251915429281854 no 2523 0.276660654229981 3455 410638
SGTC_596 1155-0152 116 µM -0.592802404786408 0.251911725683221 no 2524 0.276656699092344 3504 280313
SGTC_3243 9134147 49.47 µM -0.592808927846076 0.251909681527831 no 2525 0.276654516101839 3532 24282180
SGTC_884 0851-0618 334 µM -0.592826429679088 0.251904196956796 no 2526 0.276648659024769 3510 9642473
SGTC_2143 5623677 140.463 µM -0.59351109700582 0.251689691378751 no 2527 0.276419579335952 3500 5375313
SGTC_1141 3253-0389 52.6 µM -0.594284271561546 0.251447572604247 no 2528 0.276160998318131 3489 5402031
SGTC_3191 9110352 49.47 µM -0.595987242937293 0.250914723403248 no 2529 0.275591874523132 3497 17122424
SGTC_1482 3346-2049 8.48 µM -0.596350645757868 0.25080109433429 no 2530 0.275470501981061 3501 3826804
SGTC_1696 st025591 34.7925 µM -0.596907218352026 0.25062711762436 no 2531 0.27528466385085 3516 2787147
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.59761856604911 0.25040485350855 no 2532 0.275047236589696 3473 5379071
SGTC_2032 5185112 25.99 µM -0.597746132440538 0.250365005807524 no 2533 0.275004669291215 3430 5718189
SGTC_373 0844-0104 25.9 µM -0.599302078515026 0.249879248183841 no 2534 0.274485731041217 3529 5375804
SGTC_1361 1608-0041 5.61 µM -0.600958952583104 0.249362531922709 no 2535 0.273933663116712 3509 X1361
SGTC_191 3914-0123 66.505 µM -0.602842085879552 0.248775944315801 no 2536 0.273306873107751 3402 3144412
SGTC_1272 0839-0021 27 µM -0.602957307353148 0.248740077208646 no 2537 0.273268545380707 3511 5027250
SGTC_1120 ficusin 1.78878 µM -0.603167172256441 0.248674755776396 no 2538 0.273198741930452 3527 6199 A DNA cross-linker.
SGTC_2610 ononetin 44.17 µM -0.60402989713646 0.248406324626722 no 2539 0.272911882674838 3492 259632
SGTC_1379 2144-0755 36.5 µM -0.605160390296442 0.248054813053995 no 2540 0.27253621570576 3585 5392327
SGTC_1323 1348-1351 11.2 µM -0.60579320011724 0.247858165300517 no 2541 0.272326042849457 3437 6989654
SGTC_1292 0kpi-0043 232 µM -0.605946700743309 0.247810477015241 no 2542 0.272275073375004 3480 3333905
SGTC_1312 1218-2183 165 µM -0.606976341062596 0.247490723674481 no 2543 0.271933306632002 3545 6744073
SGTC_2048 5246248 200 µM -0.607259967225777 0.247402682715407 no 2544 0.271839200587223 3545 677046
SGTC_1942 st076330 65.2 µM -0.607574428347542 0.247305089786801 no 2545 0.271734882570406 3584 24208414
SGTC_2111 5486399 200 µM -0.608347379940541 0.247065291952476 no 2546 0.271478551553251 3543 689674
SGTC_497 capsazepine 133 µM -0.609839359195019 0.246602777454475 no 2547 0.27098411298259 3470 2733484 A calcium channel blocker.
SGTC_3318 9139014 38.6185 µM -0.6103153322137 0.246455323160507 no 2548 0.270826471170689 3528 16643984
SGTC_1961 st076550 68.7 µM -0.611116064597904 0.24620736651663 no 2549 0.270561372683415 3515 1579337
SGTC_2603 homopterocarpin 100 µM -0.61170345916798 0.246025557646668 no 2550 0.27036698640912 3528 101795 A weak amylase inhibitor.
SGTC_2299 7976368 114.88 µM -0.612307180059586 0.245838770578026 no 2551 0.270167270042555 3517 2979718
SGTC_2624 nerol 100 µM -0.613741096712303 0.245395431954493 no 2552 0.269693213305275 3498 637566 A natural product oil.
SGTC_3023 9089636 49.47 µM -0.613880141796569 0.245352464832596 no 2553 0.269647266792421 3617 17249241
SGTC_2463 5473429 200 µM -0.614906984045687 0.245035279630147 no 2554 0.269308075134945 3478 5399405
SGTC_532 1548-0774 215 µM -0.616056328191069 0.244680516140421 no 2555 0.268928671989364 3639 5932993
SGTC_3135 9127742 49.47 µM -0.616349605038943 0.244590035851204 no 2556 0.268831903109582 3490 3643468
SGTC_3258 9138477 49.47 µM -0.617143347269666 0.244345244926557 no 2557 0.268570089691668 3574 4970355
SGTC_2823 7987624 58.44 µM -0.618522654518438 0.243920179416583 no 2558 0.26811543451973 3608 2239440
SGTC_805 3852-0218 479 µM -0.620034665476079 0.243454676976119 no 2559 0.267617482272896 3506 6615355
SGTC_1382 3002-2117 298 µM -0.621852877535963 0.242895540663705 no 2560 0.267019306460735 3608 1497314
SGTC_989 1501-0895 10.3 µM -0.622295910266007 0.242759404655037 no 2561 0.266873654952866 3550 2830112
SGTC_901 1112-0062 60.1 µM -0.622485385377354 0.242701194963742 no 2562 0.266811375342923 3549 1908457
SGTC_3021 9087658 49.47 µM -0.625761004676194 0.24169606940557 no 2563 0.265735856421534 3565 25237042
SGTC_2245 6637752 200 µM -0.626438538977687 0.241488450017881 no 2564 0.265513669020628 3515 681890
SGTC_1360 1598-0022 39.8 µM -0.627536133016053 0.241152315804234 no 2565 0.265153929325068 3555 761525
SGTC_1502 4534-4282 27.7 µM -0.627824755136453 0.241063968573943 no 2566 0.265059373690636 3533 3278949
SGTC_2626 ethyl orsellinate 100 µM -0.629000712913645 0.240704189896722 no 2567 0.26467429474231 3541 75653 A natural product.
SGTC_329 k048-0121 21.3 µM -0.632606946231521 0.239602704535327 no 2568 0.263495174939618 3565 6832902
SGTC_1954 st077032 68.9 µM -0.634188648007261 0.239120460088337 no 2569 0.262978857567153 3512 698907
SGTC_2591 skatole 100 µM -0.634384151515816 0.239060889957968 no 2570 0.262915074983268 3583 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2932 9016711 44.54 µM -0.635536938606925 0.238709799483546 no 2571 0.262539141645832 3572 7117328
SGTC_3254 9136651 49.47 µM -0.63602540779795 0.238561117449373 no 2572 0.262379930861524 3555 16454030
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.637531217219987 0.238103092835889 no 2573 0.261889441320569 3584 3256 An antibiotic and ribosome inhibitor.
SGTC_1390 3413-2614 145 µM -0.638666839927425 0.237757987568538 no 2574 0.261519844524832 3585 3421432
SGTC_641 4092-0595 30 µM -0.639277768711059 0.237572445509442 no 2575 0.261321124077449 3587 786260
SGTC_1348 1493-0373 93.8 µM -0.640730168743253 0.237131663697014 no 2576 0.260849004858309 3555 3010129
SGTC_1505 k297-0037 20.6 µM -0.645374264154905 0.235725269831178 no 2577 0.259342338542991 3547 4089396
SGTC_468 gf-109203x 121 µM -0.647951551225132 0.234946766575739 no 2578 0.258508143325095 3507 2396 A protein kinase C inhibitor.
SGTC_632 0781-2353 4.65 µM -0.65049359952639 0.234180301399843 no 2579 0.257686717379805 3618 6811515 YHR007C ERG11
SGTC_2995 9067767 71.4286 µM -0.651209158806725 0.233964799653459 no 2580 0.257455739454893 3569 11673567
SGTC_737 1950-0117 57.9 µM -0.653014355329921 0.23342162528957 no 2581 0.256873511958366 3584 5393513
SGTC_2442 5158906 48.48 µM -0.65502077454168 0.232818725825449 no 2582 0.256227189326776 3609 1893835
SGTC_15 0266-0086 27.098 µM -0.655660981504336 0.232626535288326 no 2583 0.256021139683388 3680 1712902 YIL048W NEO1
SGTC_1072 oxiconazole 14.9 nM -0.657179558921695 0.232171010284993 no 2584 0.255532733749159 3631 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_985 1493-0307 8.71 µM -0.658525561768131 0.231767667540739 no 2585 0.255100238624718 3595 3278274
SGTC_3019 9081971 49.47 µM -0.658969155675432 0.231634825923465 no 2586 0.254957787787022 3655 16451803
SGTC_1887 st057648 70.8 µM -0.659831465995904 0.231376714131739 no 2587 0.254680994140339 3600 688672
SGTC_3312 9133330 71.43 µM -0.660829412904859 0.231078203130388 no 2588 0.254360858950055 3637 17617324
SGTC_2114 5491910 81.25 µM -0.661828291012067 0.230779628949016 no 2589 0.254040636383477 3649 2849228
SGTC_2317 5986382 200 µM -0.662133911746334 0.230688319068078 no 2590 0.253942702080309 3658 877883
SGTC_1227 3909-8010 46.6 µM -0.6641963048589 0.230072668685001 no 2591 0.253282339083013 3606 15982272
SGTC_906 1165-0455 526 µM -0.664449572616199 0.229997128493847 no 2592 0.253201306912701 3609 3252859
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.664916416303022 0.229857923062782 no 2593 0.253051977572438 3573 6857784
SGTC_3116 9124943 49.47 µM -0.666466271615335 0.229396119028672 no 2594 0.252556557622299 3547 41905195 YPL160W CDC60
SGTC_3147 9097027 49.47 µM -0.666890877116368 0.229269691879811 no 2595 0.2524209193192 3634 25236841
SGTC_1449 4112-4002 201 µM -0.669154310144848 0.228596409700924 no 2596 0.251698524208003 3598 2059539
SGTC_3300 9124615 50.48 µM -0.670372619964872 0.228234470731976 no 2597 0.251310142100995 3654 24824903
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.670877395629595 0.228084604972386 no 2598 0.251149318742138 3731 5282309
SGTC_1591 genipin 88.4 µM -0.672075971717627 0.227728974605488 no 2599 0.250767666244142 3623 442424 A DNA cross-linking agent.
SGTC_2380 9035439 200 µM -0.672265849268676 0.227672664554318 no 2600 0.250707233323768 3697 6462575
SGTC_2085 5307070 144.047 µM -0.672413594228278 0.227628854759531 no 2601 0.250660215410761 3595 2840351
SGTC_3337 9144342 33.5465 µM -0.673815492610341 0.227213395748699 no 2602 0.250214311977155 3630 17682949
SGTC_2031 5180455 200 µM -0.673892760051097 0.227190509621749 no 2603 0.250189747670619 3609 29949
SGTC_215 1287-0124 461.5 µM -0.674892347543502 0.226894555286571 no 2604 0.249872081367018 3633 5560863
SGTC_2266 7929956 200 µM -0.674923405701411 0.226885363181474 no 2605 0.249862214595945 3641 2967153
SGTC_1338 1486-1223 76 µM -0.674944603775684 0.226879089429466 no 2606 0.249855480363402 3647 3444526
SGTC_452 diindolylmethane 8 µM -0.67503527760469 0.226852254836109 no 2607 0.24982667606784 3599 3071 Inhibits expression of several cancer promoting factors.
SGTC_1850 st056238 17 µM -0.675174753172977 0.226810981039075 no 2608 0.249782372397584 3644 5393177
SGTC_3102 9121669 49.47 µM -0.676229253861643 0.226499068915318 no 2609 0.249447550917059 3650 41905072
SGTC_1866 st057638 64 µM -0.676960921648139 0.22628279034866 no 2610 0.249215374484997 3634 688802
SGTC_194 1486-1323 56.904 µM -0.680206711750133 0.225324753568225 no 2611 0.248186791579286 3625 5178754
SGTC_2647 atorvastatin 60.16 µM -0.683388361700838 0.22438788188591 no 2612 0.247180736103383 3629 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_927 2425-1185 123 µM -0.684466656187289 0.224070868611104 no 2613 0.246840268861529 3638 730375
SGTC_2167 5876490 200 µM -0.684503224602555 0.224060122138966 no 2614 0.246828726930889 3714 686534
SGTC_1206 3978-0017 132 µM -0.684867111481453 0.223953201541094 no 2615 0.246713890632579 3689 3873677
SGTC_3232 9132874 49.47 µM -0.685273169715656 0.223833923999272 no 2616 0.246585779578508 3640 3784940
SGTC_2470 5664817 21.68 µM -0.685526311008346 0.223759583306316 no 2617 0.246505931735176 3679 2859561
SGTC_2412 st077135 33.4 µM -0.685740359690168 0.223696734000228 no 2618 0.24643842560543 3708 13258915
SGTC_2860 9025725 38.96 µM -0.686538120953426 0.223462582532946 no 2619 0.246186916974177 3634 40546248
SGTC_2508 celastrol 40.54 µM -0.68984453700185 0.222493601909872 no 2620 0.24514597878412 3618 122724 Celastrol is a natural product and antioxidant.
SGTC_2302 7771753 200 µM -0.690369601334224 0.222339946946435 no 2621 0.244980894134515 3650 2203047
SGTC_885 0865-0106 16.8 µM -0.691104753776119 0.222124913490395 no 2622 0.244749856547314 3631 2793380
SGTC_3060 1327-0027 12.5 µM -0.692436815568648 0.221735585496639 no 2623 0.244331526269102 3595 16000455 YPR107C YTH1
SGTC_2340 7987427 183.45 µM -0.692709255644985 0.221656006197785 no 2624 0.244246014719753 3634 2239331
SGTC_2475 5812728 15.03 µM -0.692885488995824 0.221604537419695 no 2625 0.24419070844661 3662 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2917 7979103 53.79 µM -0.693831835776734 0.221328274605116 no 2626 0.243893837533609 3678 2980565
SGTC_1245 0418-0076 17.2 µM -0.693856951287466 0.221320945429523 no 2627 0.243885961400523 3669 6790114
SGTC_1965 Pectolinarigenin 58.4 µM -0.69497725282504 0.220994161705638 no 2628 0.243534778545628 3674 5320438 An anti-inflammatory.
SGTC_2090 5301565 104.445 µM -0.695055975340865 0.220971209315717 no 2629 0.243510111537903 3694 2056344
SGTC_2186 6124449 200 µM -0.695897888588641 0.22072582586343 no 2630 0.243246389846492 3624 3834182 YLR033W RSC58
SGTC_1476 4112-3294 3.34 µM -0.696299135256839 0.220608933722708 no 2631 0.243120757310496 3707 704369
SGTC_1688 st021091 57.6 µM -0.696491692897925 0.220552849965164 no 2632 0.243060478916998 3678 3656366
SGTC_2768 sulfasalazine 50.2 µM -0.696836183907905 0.220452534936754 no 2633 0.242952659351839 3701 5384001 An antioxidant and salicylic acid derivative.
SGTC_3225 9130819 49.47 µM -0.696880290128842 0.220439693190295 no 2634 0.242938856757055 3672 4547121
SGTC_1086 cerivastatin 2.18 µM -0.698557629596738 0.219951645705373 no 2635 0.242414265343238 3627 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2939 9044578 71.43 µM -0.698680178084948 0.219916012675782 no 2636 0.242375962119863 3667 2653634
SGTC_655 k060-0012 42 µM -0.698739995916326 0.21989862084064 no 2637 0.242357266909252 3638 5994525
SGTC_1421 4029-0249 71.4 µM -0.700190217990438 0.219477215212486 no 2638 0.241904259861931 3752 2894095
SGTC_1002 4049-0206 172 µM -0.701594720621855 0.219069537320345 no 2639 0.241465972480014 3710 4662749
SGTC_1297 1068-0111 14.1 µM -0.702034898581434 0.218941858764676 no 2640 0.241328699904987 3642 767057
SGTC_2499 avocadenofuran 51.48 µM -0.702824230873169 0.218713011310849 no 2641 0.241082647339318 3665 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2505 galangin 7.89 µM -0.703963902894447 0.218382834491707 no 2642 0.240727626804575 3613 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_160 3453-0671 289.699 µM -0.706708711860747 0.217588809499906 no 2643 0.239873757268558 3692 5322268
SGTC_1744 st037937 38.9 µM -0.707005858362386 0.217502950302033 no 2644 0.239781418586626 3731 1016152
SGTC_2930 9013230 14.89 µM -0.707824113482974 0.217266620118237 no 2645 0.239527244949794 3676 2995857
SGTC_3091 9116372 49.47 µM -0.708265115818897 0.217139310416178 no 2646 0.23939031793476 3703 17169793
SGTC_967 1306-0166 352 µM -0.711860767452025 0.216102917786192 no 2647 0.238275499285965 3673 4437607
SGTC_3053 9095903 49.47 µM -0.714592777575385 0.215317375858411 no 2648 0.237430354441998 3745 17174018
SGTC_3253 9135987 49.47 µM -0.716209116228025 0.214853407015016 no 2649 0.236931117440629 3693 4182430
SGTC_1583 clindamycin 39.6 µM -0.71995319931938 0.21378090419459 no 2650 0.235776905670512 3665 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1923 st058458 19.1 µM -0.720576527274748 0.21360265344268 no 2651 0.235585049972664 3742 3534982
SGTC_2313 7726885 200 µM -0.721470479734823 0.213347164428205 no 2652 0.235310048459074 3702 726423
SGTC_811 0416-0114 265 µM -0.723992289743637 0.212627399329348 no 2653 0.23453523430986 3731 6612453
SGTC_669 0108-0021 26.2 µM -0.724663681981967 0.212436012491985 no 2654 0.234329190365872 3762 17201
SGTC_1330 1469-0054 61.8 µM -0.726346470690857 0.211956759834613 no 2655 0.233813198890374 3724 7102664
SGTC_316 k060-0003 58.6 µM -0.727101968834952 0.211741802320344 no 2656 0.233581746375081 3707 6152314
SGTC_1885 st057546 99.9 µM -0.727746257125045 0.211558587531944 no 2657 0.233384464248288 3776 702008
SGTC_826 1683-5028 118 µM -0.728122813304272 0.211451550100166 no 2658 0.233269204948519 3774 722377
SGTC_2566 crystal violet carbinol 226 nM -0.728848739341132 0.211245292568179 no 2659 0.233047096931792 3690 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2020 4017018 200 µM -0.729674540197553 0.211010800959101 no 2660 0.232794573552823 3787 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.731042034056668 0.210622827780203 no 2661 0.232376739287129 3725 688667
SGTC_134 0269-0018 6.916 µM -0.735854962075244 0.209260679751801 no 2662 0.230909484290692 3666 4378915
SGTC_1207 2099-0101 141 µM -0.736065176930579 0.209201303468989 no 2663 0.230845516928833 3765 5837381
SGTC_2278 7948257 134.34 µM -0.736532794057729 0.209069258147236 no 2664 0.230703258799254 3696 1247028
SGTC_2306 7482397 179.52 µM -0.736725601251807 0.209014827711398 no 2665 0.230644617402652 3724 891448
SGTC_1405 3909-7894 12 µM -0.73707435528996 0.208916393905297 no 2666 0.230538566670217 3739 7104060
SGTC_1219 1469-0211 33.1 µM -0.737463547096433 0.208806579021334 no 2667 0.230420251617052 3705 6822282
SGTC_758 0868-0029 16 µM -0.737925783484618 0.208676197977366 no 2668 0.230279774982039 3774 762687
SGTC_1650 st011916 45.8 µM -0.738411991893079 0.208539107044504 no 2669 0.230132064794025 3699 242528
SGTC_1509 1326-1131 80 µM -0.739422292978876 0.208254413229413 no 2670 0.229825304744005 3687 768313
SGTC_477 mead ethanolamide 10 µM -0.740752903846415 0.207879809077414 no 2671 0.229421637848639 3616 16061185
SGTC_3062 9077494 49.47 µM -0.742128185070819 0.207493047450203 no 2672 0.229004837258277 3709 16459633
SGTC_1997 st073024 93.8 µM -0.743118919096236 0.207214693328307 no 2673 0.228704843194632 3725 686268
SGTC_774 k060-0086 136 µM -0.743773347900891 0.207030947850834 no 2674 0.228506803362406 3758 5911235
SGTC_1842 st055362 61.2 µM -0.745050085317468 0.206672752979572 no 2675 0.22812072118399 3739 676032
SGTC_83 0170-0301 39.027 µM -0.746854567829819 0.206167123025656 no 2676 0.227575676324231 3697 3089716
SGTC_2433 5607874 27.82 µM -0.747063736907285 0.206108559702795 no 2677 0.227512544159216 3756 2252428
SGTC_2813 7971799 71.43 µM -0.748661535642809 0.205661532304946 no 2678 0.227030616350103 3811 2234054
SGTC_3286 9117135 37.221 µM -0.74925673549555 0.205495156277789 no 2679 0.226851239517503 3745 3438150
SGTC_1065 prochlorperazine maleate 2.48 µM -0.750208044629061 0.205229403144256 no 2680 0.226564707239447 3797 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2487 5918373 44.05 µM -0.751931948906644 0.204748342163299 no 2681 0.226045991892091 3768 2876279
SGTC_722 3534-0461 190 µM -0.752227827449854 0.204665843800425 no 2682 0.225957030860262 3757 658262
SGTC_386 1509-0011 3.07 µM -0.752915838078411 0.204474085642242 no 2683 0.225750245042085 3804 3107280
SGTC_2013 4024628 200 µM -0.753836395972906 0.204217680637721 no 2684 0.225473733225045 3776 5230760
SGTC_2449 5812982 45.77 µM -0.755469251464428 0.203763349131238 no 2685 0.224983737545793 3719 776185
SGTC_749 1000-0129 128 µM -0.756289729863098 0.203535283945958 no 2686 0.224737752157811 3804 708470
SGTC_703 3875-0075 71.8 µM -0.75873627201617 0.202856132601766 no 2687 0.224005167192515 3804 2850814
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.758801567223062 0.202838025452582 no 2688 0.223985634004619 3838 4213774
SGTC_487 nimodipine 119 µM -0.759436890958091 0.20266189291876 no 2689 0.223795626200505 3655 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1990 st072050 59.8 µM -0.760163589081873 0.202460540521873 no 2690 0.223578403214565 3776 17233948
SGTC_2194 5927483 104.545 µM -0.760384811460598 0.202399268322451 no 2691 0.223512299729453 3790 760979
SGTC_1113 artemisinin 1.17947 µM -0.760905097075352 0.202255207971527 no 2692 0.223356876950679 3775 2240 An anti-malaria and mitochondrial poison.
SGTC_2052 5265182 7.135 µM -0.761148500193212 0.202187833863966 no 2693 0.223284187260467 3772 1239884
SGTC_178 4092-0806 87.505 µM -0.761423683053252 0.202111679281109 no 2694 0.223202023114118 3731 2169044
SGTC_1619 st003326 88.7 µM -0.761870494511947 0.201988064467237 no 2695 0.223068650738544 3723 2849032
SGTC_2162 5663267 200 µM -0.763100922670681 0.201647888308485 no 2696 0.222701604916189 3748 6456493
SGTC_1142 3253-1408 9.78 µM -0.763498871495785 0.201537940984475 no 2697 0.222582967547994 3728 256655
SGTC_940 3232-1287 54.8 µM -0.763583363555311 0.201514601712326 no 2698 0.222557783229787 3718 1585493 YIL048W NEO1
SGTC_575 k072-0246 11.9 µM -0.764078278754646 0.201377923637222 no 2699 0.222410297837683 3805 6796779
SGTC_234 nsc-17383 10.7 µM -0.765096522802775 0.20109689545677 no 2700 0.222107035144699 3786 408974
SGTC_1982 st072467 71.9 µM -0.766359255471093 0.200748717040378 no 2701 0.221731284676332 3771 3163533
SGTC_40 0327-0103 19.753 µM -0.766390379241462 0.200740139728239 no 2702 0.221722027786377 3687 409036
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.767367984130093 0.200470836335581 no 2703 0.221431379121723 3707 1241132 A phosphatase inhibitor.
SGTC_394 menadione 8.33 µM -0.767701227162293 0.200379086612912 no 2704 0.221332353479429 3728 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3159 9100096 49.47 µM -0.767958943636292 0.200308148446285 no 2705 0.221255788484403 3748 25236875
SGTC_1510 1123-0200 71.5 µM -0.76807808420194 0.200275359317089 no 2706 0.221220398131447 3813 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3282 9108498 15.4605 µM -0.768776319627869 0.20008326012828 no 2707 0.221013054471742 3788 16459645
SGTC_2655 perillic acid 100 µM -0.769438703895793 0.199901126759754 no 2708 0.220816459795212 3811 5702197 An apoptosis inducer.
SGTC_450 aminopyrene 156 nM -0.771131024371991 0.19943624860728 no 2709 0.220314636547611 3725 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1807 st050092 58.9 µM -0.771544269352649 0.199322829710799 no 2710 0.220192196540545 3801 5008496
SGTC_1182 1222-0449 220 µM -0.774736398382344 0.198448029919014 no 2711 0.219247719206637 3787 658318
SGTC_1891 st059073 26.2 µM -0.776603049351977 0.197937551134144 no 2712 0.218696500957263 3807 688754
SGTC_1261 0712-0010 12.7 µM -0.77728891314357 0.197750185287579 no 2713 0.218494167324227 3773 2840123
SGTC_2781 5567276 71.43 µM -0.777464238431313 0.197702306728067 no 2714 0.21844246269428 3833 2853274
SGTC_2808 7946468 45.46 µM -0.779381168247369 0.197179280717962 no 2715 0.217877606833487 3824 2970879
SGTC_2255 7941087 197.44 µM -0.780039884813594 0.19699974619938 no 2716 0.217683699467072 3802 935561
SGTC_647 0140-0236 81 µM -0.781817796005667 0.196515667116314 no 2717 0.217160830466836 3807 990837
SGTC_148 3253-0744 288.01 µM -0.787863644565168 0.19487493990338 no 2718 0.215388234266428 3763 6893655
SGTC_1641 st009299 47.1 µM -0.788226917849842 0.194776620552192 no 2719 0.215281993363626 3739 4046054
SGTC_1490 4089-0339 670 nM -0.790321822975918 0.194210226661247 no 2720 0.214669922584861 3766 742542
SGTC_1985 st071382 65.5 µM -0.790863362834027 0.194063975309091 no 2721 0.214511864939773 3832 6123237
SGTC_540 1187-0821 17.3 µM -0.79116030712526 0.193983809326149 no 2722 0.214425225411891 3779 847520
SGTC_995 3931-2021 34.6 µM -0.791351290408505 0.19393226027683 no 2723 0.2143695129141 3827 730143
SGTC_1367 1812-0510 76.9 µM -0.792716186105377 0.193564098982209 no 2724 0.213971598871437 3858 1142582 YDR527W RBA50
SGTC_3352 9151559 45.5865 µM -0.79325942559166 0.193417686492183 no 2725 0.213813345573999 3822 17159339
SGTC_534 k292-0788 63.4 µM -0.795024801458603 0.192942353745626 no 2726 0.213299537667382 3822 4146317
SGTC_611 3453-1652 23.7 µM -0.795677760235136 0.192766723530414 no 2727 0.213109678299658 3787 1560575
SGTC_183 3914-0051 30.55 µM -0.797367265200251 0.192312740851459 no 2728 0.212618882472026 3840 1596232
SGTC_32 0928-0142 34.1 µM -0.802400075007522 0.190964266855187 no 2729 0.21116078485833 3783 2244242
SGTC_1145 3546-0597 10.2 µM -0.803141889899861 0.190765999067202 no 2730 0.210946364029406 3804 875334
SGTC_2138 5575593 77.673 µM -0.803789758460808 0.190592944062342 no 2731 0.210759202762886 3811 762213
SGTC_216 k038-0035 28.382 µM -0.805087311637776 0.190246638867699 no 2732 0.210384648621581 3751 4444231 YPR107C YTH1
SGTC_1689 st020265 53.493 µM -0.805411143511515 0.190160271386161 no 2733 0.210291231674139 3812 5758320 YPR016C TIF6
SGTC_1896 st058441 89 µM -0.807542643590016 0.189592391678988 no 2734 0.209676958226336 3869 688759
SGTC_293 4049-0273 38.5 µM -0.808097501221065 0.189444736407662 no 2735 0.209517227987052 3742 1380311
SGTC_1725 st036284 20.55 µM -0.808296739714588 0.189391733568459 no 2736 0.209459889461814 3946 707914
SGTC_953 1188-0045 9.7 µM -0.808704417647211 0.189283308637353 no 2737 0.209342593262539 3881 6144426
SGTC_314 1671-0008 2.74 µM -0.810242915607988 0.188874478162603 no 2738 0.208900288349117 3766 3913060
SGTC_518 1021-0119 62.6 µM -0.813518219104714 0.188005934142163 no 2739 0.207960502432405 3851 1097762
SGTC_2676 harmalol 100 µM -0.814022178858707 0.187872513454383 no 2740 0.20781612269318 3813 5459187 A monoamine oxidase inhibitor
SGTC_2094 5332512 191.667 µM -0.81441404088601 0.187768810465481 no 2741 0.207703898824243 3901 755774
SGTC_1053 3366-3204 134 µM -0.814532330358031 0.187737513100283 no 2742 0.207670029390279 3874 3632071 YPR165W RHO1
SGTC_2968 9090663 33.37 µM -0.81499644140687 0.187614748403654 no 2743 0.207537173525844 3839 25236811
SGTC_2468 5987765 72.9 µM -0.815166931046923 0.18756966366281 no 2744 0.207488381986609 3895 26772094
SGTC_1175 0741-0056 27.6 µM -0.815487844845507 0.187484818513112 no 2745 0.20739655973712 3931 765927
SGTC_3020 9089140 49.47 µM -0.817131533720503 0.187050621975351 no 2746 0.206926631975717 3924 17217859
SGTC_1 0258-0098 57.368 µM -0.81849240135856 0.186691606543513 no 2747 0.20653803957602 3806 6790032 YDR047W HEM12
SGTC_2195 6536160 144.242 µM -0.819278701454875 0.186484364441477 no 2748 0.206313710692144 3786 3834386
SGTC_2399 5884133 200 µM -0.820036688658067 0.186284719597376 no 2749 0.206097596141627 3876 722445
SGTC_874 0599-0792 117 µM -0.821025864111102 0.186024381774025 no 2750 0.205815768020355 3844 765305
SGTC_153 4077-0274 519.67 µM -0.826843753205874 0.18449775944746 no 2751 0.204162813629209 3888 3121976
SGTC_1876 myriocin 605 nM -0.828085926009204 0.184172823852225 no 2752 0.20381091969671 3856 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2525 harmine 47.85 µM -0.828250722338949 0.184129742140358 no 2753 0.203764261882235 3882 5280953 A monoamine oxidase inhibitor
SGTC_1613 st002381 52.1 µM -0.82915710995376 0.183892902833552 no 2754 0.203507755534651 3846 551167
SGTC_410 α-linolenic acid 100 µM -0.830591199952486 0.183518562529127 no 2755 0.20310230387149 3955 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1282 0886-0010 32.4 µM -0.83072384373903 0.183483962553588 no 2756 0.203064826671576 3941 2836211 YNL267W PIK1
SGTC_551 k048-0028 34.9 µM -0.834030475370593 0.182622746072976 no 2757 0.20213190543733 3862 6836383
SGTC_1486 3970-0793 4.53 µM -0.834593874030928 0.182476260250098 no 2758 0.201973206245042 3918 2844330
SGTC_1561 5-methoxyflavone 52.9 µM -0.835614549729292 0.182211067626211 no 2759 0.2016858904139 3812 94525
SGTC_3036 9090181 49.47 µM -0.83632514115256 0.182026583600682 no 2760 0.201486006596845 3900 25236586
SGTC_176 1486-1328 72.834 µM -0.836926352374238 0.181870588145542 no 2761 0.201316983315416 3943 22310231
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.838553793217184 0.181448737967601 no 2762 0.20085987460357 3887 6708739 YPR165W RHO1
SGTC_1996 st072960 66.8 µM -0.83862345568278 0.181430694388536 no 2763 0.200840322015002 3858 1719405
SGTC_3129 9127257 49.47 µM -0.840607280373311 0.180917326848133 no 2764 0.200283989392318 3881 837894
SGTC_1286 0929-0070 131 µM -0.840942237151925 0.180830737766256 no 2765 0.20019014745281 3989 1420408
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.842003975675245 0.180556441338241 no 2766 0.199892864045078 3932 279621
SGTC_656 4090-1979 187 µM -0.842105270345666 0.180530285857634 no 2767 0.19986451573921 3913 22330961
SGTC_1909 st060837 51.5 µM -0.843088864468183 0.180276433822947 no 2768 0.199589373036795 3913 678937
SGTC_1730 st033808 45.1 µM -0.844806219231628 0.179833745626444 no 2769 0.199109520825917 3860 1045166
SGTC_567 1080-0542 68.4 µM -0.845499288118202 0.179655284529777 no 2770 0.198916064985751 3796 5950415
SGTC_2211 7117706 200 µM -0.846445428755061 0.179411838693837 no 2771 0.198652152365799 3812 822771
SGTC_1268 0828-0275 2.46 µM -0.847074743794179 0.179250028280411 no 2772 0.19847673078172 3946 745337
SGTC_1574 spiramycin 23.7 µM -0.85101741792297 0.178238371862735 no 2773 0.197379838625795 3881 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2570 licareol 100 µM -0.851497615879787 0.178115403470998 no 2774 0.197246493564668 3927 443158
SGTC_1121 fusaric acid 630.51 nM -0.852536906651077 0.177849446591158 no 2775 0.196958081984852 3904 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_560 2332-1943 155 µM -0.853221027648891 0.177674515247285 no 2776 0.196768372287595 3885 21177716
SGTC_3329 9141233 27.5565 µM -0.853937126805083 0.177491523352674 no 2777 0.196569913495092 3899 4909101 YNL103W MET4
SGTC_1417 3966-0327 90.4 µM -0.855797558238571 0.177016665182834 no 2778 0.196054883040207 3978 651118
SGTC_2280 7785178 200 µM -0.860022945489199 0.175941158716791 no 2779 0.194888197118693 3923 2954328
SGTC_672 1441-0018 53.7 µM -0.861618494397988 0.175536115163778 no 2780 0.194448745168486 3902 251141
SGTC_1758 st042942 75.2445 µM -0.862013215361583 0.175436003173972 no 2781 0.194340122808947 3845 669317
SGTC_2106 5357045 167.29 µM -0.863503080661471 0.175058458955412 no 2782 0.193930463187107 3952 668842
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.864198441190816 0.17488242539197 no 2783 0.193739444196297 3949 6708760
SGTC_48 0382-0018 55 µM -0.86485508625659 0.17471629598657 no 2784 0.193559165883782 3958 762596
SGTC_2602 kawain 100 µM -0.865587431816331 0.174531132784245 no 2785 0.193358225146267 3882 5369129
SGTC_968 1309-0633 340 µM -0.868336882436848 0.173837085906765 no 2786 0.192604968430296 3964 3761976
SGTC_1919 st067113 52.3 µM -0.86977553491106 0.173474625780985 no 2787 0.192211541927827 3994 1268243
SGTC_977 1348-1378 135 µM -0.870385693778001 0.173321045172813 no 2788 0.192044831109244 3922 X977
SGTC_1215 3852-0577 11.2 µM -0.871898073049509 0.172940743678385 no 2789 0.191631992508427 3999 2884876
SGTC_695 3505-6186 243 µM -0.873877996169182 0.172443678349031 no 2790 0.191092349426349 3945 1819379
SGTC_2375 9072683 200 µM -0.874354583098048 0.172324166049167 no 2791 0.190962591324881 3948 16798029
SGTC_3006 9075424 71.4286 µM -0.875915761138505 0.171933044201295 no 2792 0.190537915281381 3888 7465181
SGTC_893 0958-0369 48.9 µM -0.876596965578626 0.171762559846608 no 2793 0.190352793974697 3919 6819948
SGTC_2702 st077768 96.8 µM -0.878277878844541 0.171342341472011 no 2794 0.189896468753304 3923 6484119
SGTC_1027 k015-0025 8.67 µM -0.878721148367 0.17123163631052 no 2795 0.18977624450255 3926 3598955
SGTC_337 1315-0038 354 µM -0.879083251255787 0.171141236206502 no 2796 0.189678069137212 3905 1626437
SGTC_501 nsc-95397 161 µM -0.87950087883846 0.171037012099111 no 2797 0.189564878406057 3995 262093
SGTC_2594 a-mangostin 100 µM -0.879713937425643 0.170983856347416 no 2798 0.189507148574272 3994 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2696 st077691 74.316 µM -0.880034810289937 0.170903822076142 no 2799 0.189420226067738 3990 757133
SGTC_355 1311-2252 105 µM -0.880563694929762 0.170771956429931 no 2800 0.189277008000703 3949 5338538
SGTC_824 1304-0008 100 µM -0.880739041470645 0.170728252038764 no 2801 0.18922954016684 3960 768245
SGTC_2126 5251174 33.877 µM -0.883076627072194 0.170146302597561 no 2802 0.188597435758484 3963 790722
SGTC_3275 9138069 49.47 µM -0.884785056050804 0.169721788687165 no 2803 0.188136285433171 4044 17617007
SGTC_2685 mycophenolic acid 18.85 µM -0.886954267240209 0.169183758406098 no 2804 0.187551761475057 3924 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1146 3579-1023 7 µM -0.887800406559369 0.168974187366752 no 2805 0.187324062102536 4004 X1146
SGTC_2339 9000433 200 µM -0.889133272929159 0.168644402574872 no 2806 0.186965729412739 3972 2988954
SGTC_553 k007-0256 45.7 µM -0.894046982345693 0.167432203529392 no 2807 0.185648377070173 4014 6287000
SGTC_1098 clofazimine 15.1 µM -0.895239985484996 0.167138741940175 no 2808 0.185329407078991 4031 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2192 5915882 198.485 µM -0.895452840831533 0.167086417473308 no 2809 0.185272532317858 3926 2876149
SGTC_1276 0871-0068 94.2 µM -0.895742188351044 0.16701530650852 no 2810 0.185195236297793 3971 3414906
SGTC_2904 7225135 42.03 µM -0.900762948449093 0.165784496884687 no 2811 0.183857185720301 4062 4446116
SGTC_1826 st055655 41.6 µM -0.901208361777224 0.16567559033398 no 2812 0.183738772950674 4004 676168
SGTC_827 3253-0474 693 µM -0.902145023745796 0.165446721155076 no 2813 0.183489917181416 3998 5402065
SGTC_2636 apigenin dimethyl ether 100 µM -0.903173328920293 0.165195695011075 no 2814 0.183216955362313 4001 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2215 7188065 200 µM -0.903562479148797 0.165100761394852 no 2815 0.183113722200048 3984 940217
SGTC_3162 9099653 49.47 µM -0.904003411317632 0.16499323820657 no 2816 0.182996796263814 3944 25237511
SGTC_2528 xanthyletin 44.79 µM -0.90445072155736 0.164884206039134 no 2817 0.18287822661117 4011 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1357 1503-1303 39.5 µM -0.905940701083101 0.164521359219282 no 2818 0.182483619951712 3947 292895
SGTC_1453 4237-0541 195 µM -0.90810050726623 0.163996312557806 no 2819 0.181912561249269 3962 739892
SGTC_3045 9092950 49.47 µM -0.908686456358788 0.16385405661584 no 2820 0.181757827635364 3928 44120432
SGTC_550 4123-0385 25.7 µM -0.909414719587874 0.163677361490202 no 2821 0.181565627435105 3996 5731123
SGTC_609 0986-0026 86.3 µM -0.90966082574165 0.163617677872074 no 2822 0.181500704889799 3945 2848610
SGTC_1489 4065-0444 182 µM -0.910383730413046 0.16344244676528 no 2823 0.181310087437561 3944 2877968
SGTC_1921 5740136 50 µM -0.912227511455995 0.162996068875683 no 2824 0.180824482148151 3894 1774243
SGTC_3295 9122362 53.5725 µM -0.916527384883366 0.161958155285762 no 2825 0.179695175489007 4045 4730473
SGTC_821 1114-0266 29.2 µM -0.91797125550031 0.161610598100996 no 2826 0.179316957390162 4017 3123235
SGTC_778 3456-2434 196 µM -0.918069578706343 0.161586948206331 no 2827 0.179291220103161 3989 5539063
SGTC_1790 st045711 43.5 µM -0.918740310865275 0.161425675735762 no 2828 0.17911570983788 3974 585119
SGTC_2364 9055074 200 µM -0.919280204505319 0.161295938670515 no 2829 0.178974514586319 4021 6470630
SGTC_2022 5136654 200 µM -0.920666569444492 0.160963105217672 no 2830 0.178612267554625 4056 1713771
SGTC_2333 9017922 200 µM -0.92161497211237 0.160735674564733 no 2831 0.178364723028704 4064 3163164
SGTC_1622 st003707 19.4 µM -0.922327404657128 0.160564968552986 no 2832 0.178178911799583 4024 10140899
SGTC_2693 st077581 40.7 µM -0.925974796999987 0.159692872477357 no 2833 0.177229539031938 4055 25238761
SGTC_1895 st058434 18.3 µM -0.929313188650493 0.15889738066273 no 2834 0.176363401125198 4021 5393175
SGTC_2190 6049624 200 µM -0.931153037331118 0.158460082507612 no 2835 0.175887203363368 3879 2265554
SGTC_2709 st078560 56 µM -0.936483579594187 0.157197571696048 no 2836 0.174512131533615 3996 17250903
SGTC_1080 nisoldipine 24.4 µM -0.936554641952576 0.157180785750348 no 2837 0.17449384645734 4002 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1398 3558-0053 112 µM -0.936667746253838 0.15715407132729 no 2838 0.174464746066201 3909 4532369
SGTC_393 acivicin 6.25 µM -0.938600315480505 0.156698073752794 no 2839 0.17396799538029 3863 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_305 1682-2595 20.8 µM -0.939047376969326 0.156592711930444 no 2840 0.173853210186373 4040 226033
SGTC_2284 7945075 39.21 µM -0.939461220335384 0.156495220413181 no 2841 0.173746996847053 4034 1245402
SGTC_284 0988-0104 32.6 µM -0.940530260054662 0.156243565437985 no 2842 0.173472817750109 4004 4666532
SGTC_1508 1080-0625 72.9 µM -0.941739022194153 0.155959340721871 no 2843 0.17316313563284 3894 767111
SGTC_2341 7987486 176.74 µM -0.942132119487326 0.155866982482463 no 2844 0.173062500915308 4049 1258686
SGTC_1128 3448-9350 235 µM -0.942423810904004 0.15579847287128 no 2845 0.172987850653149 4079 619386
SGTC_384 k007-0144 5.16 µM -0.942955021638873 0.155673758329732 no 2846 0.172851954827495 3991 6824886
SGTC_1132 3456-3614 2.5 µM -0.948495329799213 0.154376962446371 no 2847 0.17143867460484 4115 3125502
SGTC_1789 tunicamycin 25 nM -0.949025845109485 0.154253162820838 no 2848 0.171303733697771 3947 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2680 butyl paraben 22.24 µM -0.950864553435409 0.153824595046617 no 2849 0.170836568882199 4093 7184 An antifungal and steroid mimetic.
SGTC_3202 9113761 49.47 µM -0.951713715137071 0.153626937963625 no 2850 0.170621095887961 4066 4798415
SGTC_3111 9122088 49.47 µM -0.951747548458591 0.153619066157701 no 2851 0.170612514359588 3890 16876704
SGTC_2206 7254556 146.969 µM -0.952755173468462 0.153384750216148 no 2852 0.170357065686584 4032 4398905
SGTC_730 1436-0052 41.2 µM -0.95333548031522 0.153249911534159 no 2853 0.170210060072407 4051 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3316 9136639 10.545 µM -0.954807534127161 0.152908221129024 no 2854 0.169837518329181 4056 4903665
SGTC_378 3970-0959 8.33 µM -0.955735894775971 0.152692991713443 no 2855 0.16960284141688 4068 6615653
SGTC_3339 9145883 14.936 µM -0.958885255096677 0.151964347697739 no 2856 0.168808276808492 3965 2030670
SGTC_1370 2001-0092 44.6 µM -0.959471152686626 0.151829048174385 no 2857 0.168660722682349 4111 790957
SGTC_2545 solidagenone 89.61 µM -0.962108810216466 0.151220933569758 no 2858 0.167997474499509 3848 6708572 An anti ulcer agent
SGTC_3250 9135583 49.47 µM -0.963471871205794 0.150907314340779 no 2859 0.167655386840147 4090 7699353
SGTC_790 1575-0012 79.1 µM -0.964756779146164 0.150612073602203 no 2860 0.167333324348881 4111 378741 YLR208W SEC13
SGTC_167 3672-0051 66.205 µM -0.966754126380579 0.150153895823184 no 2861 0.166833480946235 3976 3237971
SGTC_1755 st041960 45.185 µM -0.967058975968644 0.150084047225732 no 2862 0.16675727604142 4119 2257073
SGTC_1240 0356-0016 42.1 µM -0.968220051109101 0.149818214519203 no 2863 0.166467241492757 4040 4305613
SGTC_1831 st055328 12 µM -0.971422813166923 0.149086558476105 no 2864 0.165668886384859 4064 1103068
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.973115153305994 0.14870091661435 no 2865 0.165248036786976 4118 23847180
SGTC_1812 st052057 4.327 µM -0.978305876885886 0.147522243152536 no 2866 0.163961532076966 4085 3645418
SGTC_1643 st009866 20.2 µM -0.979125525084642 0.147336696916966 no 2867 0.163758980515992 4012 3156273 YOR207C RET1
SGTC_1646 st011709 75.6 µM -0.979273473187747 0.147303222128869 no 2868 0.163722436874825 3985 5757843
SGTC_2772 vinpocetine 57.06 µM -0.982926372023369 0.146478332574818 no 2869 0.162821838638246 4100 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1975 st070967 30.8 µM -0.983006434041069 0.146460287940704 no 2870 0.162802136019707 4040 261391
SGTC_1980 st071811 45.7 µM -0.983757647827632 0.146291049659416 no 2871 0.162617343879446 4168 4974850
SGTC_3043 9092303 49.47 µM -0.984678783571764 0.146083709567547 no 2872 0.162390938720985 4065 25236084
SGTC_1469 k284-2957 126 µM -0.985132808510346 0.145981584949357 no 2873 0.162279419843616 4052 23884841
SGTC_1836 st055642 81 µM -0.985631459319626 0.145869477843008 no 2874 0.162156997296526 4081 8571
SGTC_634 1611-4317 11.2 µM -0.988241166909827 0.145283705068792 no 2875 0.161517275572242 4080 2843522
SGTC_2328 6201408 200 µM -0.991427047047707 0.14457075317701 no 2876 0.16073854934188 4079 2890418
SGTC_1093 fluphenazine 7.97 µM -0.991879520725844 0.144469687876843 no 2877 0.16062815013602 4078 6602611 An atypical antipsychotic.
SGTC_2546 rhodinyl acetate 100 µM -0.993974543779072 0.14400236054868 no 2878 0.160117630421586 4029 6708682
SGTC_1778 st046819 58.9 µM -0.994446596007486 0.143897202889494 no 2879 0.160002746324245 4137 671715
SGTC_700 3453-2283 142 µM -0.994562237418368 0.143871449700489 no 2880 0.15997461071331 4138 565664
SGTC_3136 9095672 49.47 µM -0.996155001987275 0.14351705946889 no 2881 0.159587419530732 3797 17217380
SGTC_1160 4092-0570 10.5 µM -0.999449966801771 0.142785801377222 no 2882 0.158788382465431 4077 4994975
SGTC_1208 2323-2347 50.3 µM -0.999641907537584 0.142743281359672 no 2883 0.158741917338011 4110 5412760
SGTC_2448 5185112 27.17 µM -0.999800833552202 0.142708081466384 no 2884 0.15870345118029 4115 5718189
SGTC_808 0711-0032 135 µM -1.00461922162848 0.141643661544947 no 2885 0.157540119008021 4010 4252555
SGTC_3226 9131256 49.47 µM -1.00467780208984 0.141630753837254 no 2886 0.157526010142395 4030 17178073
SGTC_689 0833-0039 98 µM -1.00563364159219 0.141420255285429 no 2887 0.157295917396882 4058 5374726
SGTC_2429 5902844 64.44 µM -1.00643825346102 0.141243225089017 no 2888 0.157102400019527 4110 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1587 estradiol valerate 56.1 µM -1.00939167132928 0.140594704157062 no 2889 0.156393415590119 4151 13791 A steroid.
SGTC_2204 7233102 200 µM -1.01454974360911 0.139466932163228 no 2890 0.155160253028779 4004 2172480
SGTC_2160 5660466 132.927 µM -1.01457240841117 0.139461990299153 no 2891 0.155154848660705 3993 2859134
SGTC_2750 bromebric acid 70.15 µM -1.01619612243564 0.139108263398389 no 2892 0.154768001268884 4153 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1176 0848-0131 83.3 µM -1.01700533244311 0.1389322047993 no 2893 0.154575446347192 4142 6769040
SGTC_2689 tacrolimus 100 µM -1.01889683307837 0.138521265847321 no 2894 0.154125973678317 4141 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1491 4138-0063 26.5 µM -1.01972924209395 0.138340683101978 no 2895 0.153928444589448 4075 23883227
SGTC_2846 9008642 19.48 µM -1.01995123264754 0.138292551604187 no 2896 0.153875794957839 4183 2992898
SGTC_1332 1480-0653 17.5 µM -1.02128572873089 0.138003449723519 no 2897 0.153559542926809 4111 5749438
SGTC_2663 amphotericin b 100 µM -1.02233243146357 0.137776983321448 no 2898 0.153311794253475 4112 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_348 k064-0012 10.7 µM -1.0226217507772 0.137714430456288 no 2899 0.153243360735353 4021 5066323
SGTC_271 rotenone 740 µM -1.02515328420376 0.13716792188479 no 2900 0.15264543344947 4177 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_818 4072-2707 53.5 µM -1.0260583221207 0.136972901882904 no 2901 0.152432047034519 4019 882871
SGTC_489 paxilline 115 µM -1.02639604335069 0.136900177372608 no 2902 0.152352471145628 4118 105008 A toxic potassium channel blocker.
SGTC_3203 9113543 49.47 µM -1.02964296571011 0.136202335252551 no 2903 0.151588819059159 4203 17018012
SGTC_2893 9048488 25.97 µM -1.02969381748816 0.136191425372229 no 2904 0.151576879370206 4160 6467338
SGTC_1692 fluoroquinolonic acid 71 µM -1.03006483935053 0.136111843421363 no 2905 0.151489784608518 4166 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3251 9135047 49.47 µM -1.0315497862445 0.135793649930919 no 2906 0.151141536944995 4147 17682963
SGTC_2384 9036245 200 µM -1.03341314836243 0.135395091081869 no 2907 0.150705297965431 4061 6462766
SGTC_1724 st037281 8.293 µM -1.03375932311361 0.135321135358313 no 2908 0.150624346083935 4094 574124 YDL195W SEC31
SGTC_1181 1222-0449 220 µM -1.03596895727428 0.134849728305705 no 2909 0.150108312509784 4199 658318
SGTC_3068 9116768 49.47 µM -1.03976229698077 0.134043080716772 no 2910 0.149225174855625 4124 41904888
SGTC_492 tmb-8 126 µM -1.04099304706639 0.133782077470829 no 2911 0.148939387589308 4080 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2900 5328528 85.29 µM -1.04323509662609 0.133307507887668 no 2912 0.148419711182143 4130 795359
SGTC_2087 5276107 200 µM -1.04404550548881 0.133136255801529 no 2913 0.148232168244615 4105 144405
SGTC_535 2293-4129 48.2 µM -1.04487997187519 0.13296007826313 no 2914 0.148039223717075 4154 396118 YIL048W NEO1
SGTC_2628 lathosterol 100 µM -1.04519632255759 0.132893330389178 no 2915 0.147966121371364 4199 6710616
SGTC_2529 gangaleoidin 93.61 µM -1.04572377737354 0.132782092267483 no 2916 0.147844290800688 4167 4565183
SGTC_2183 6420625 130.508 µM -1.04691967201168 0.132530120408734 no 2917 0.147568314020592 4126 2897619
SGTC_3133 9127736 49.47 µM -1.0477951126586 0.132345876345126 no 2918 0.147366507368264 4161 27243420
SGTC_2913 7966556 36.57 µM -1.04862371440703 0.13217165262519 no 2919 0.147175668467231 4008 2976516
SGTC_1716 st033144 30.6155 µM -1.04862815647601 0.132170719051817 no 2920 0.147174645841521 4156 674617
SGTC_643 k048-0106 28.4 µM -1.04946147389837 0.131995664200371 no 2921 0.14698288891037 4145 6763920
SGTC_1946 st076057 65.1 µM -1.05237887232711 0.131384066960563 no 2922 0.146312879037588 4081 953009
SGTC_2142 5622915 118.518 µM -1.0539175077479 0.131062299963115 no 2923 0.145960343252644 4171 5322196
SGTC_2910 7948405 25.97 µM -1.05491190465228 0.130854636646163 no 2924 0.145732808562204 4070 2971328
SGTC_651 3253-0966 34.4 µM -1.05662144080854 0.130498160093616 no 2925 0.145342195598858 4167 781462
SGTC_2099 5377090 177.372 µM -1.05717298802677 0.13038329357791 no 2926 0.145216322649451 4155 2243829
SGTC_223 busulfan 5 mM -1.05804262038217 0.130202324009638 no 2927 0.14501800602257 4149 2478 A DNA alkylator.
SGTC_793 0488-0545 106 µM -1.06246426259887 0.129284873811346 no 2928 0.14401248679027 4180 292548
SGTC_1170 0310-0127 64.8 µM -1.06278387688191 0.129218730859833 no 2929 0.143939986438504 4180 774975
SGTC_3246 9135460 32.98 µM -1.06843528519823 0.12805306678155 no 2930 0.142662103785196 4130 41446951
SGTC_1394 3474-0001 65.7 µM -1.06865829668139 0.128007218544675 no 2931 0.142611834783985 4168 5017666 YIL048W NEO1
SGTC_2607 solasodine 47.35 µM -1.06976234326792 0.127780409028353 no 2932 0.142363148165431 4139 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2886 9058944 51.95 µM -1.07102183810452 0.127522006282793 no 2933 0.142079805255856 4022 4949929
SGTC_1973 st070275 50.2 µM -1.07116060924519 0.127493557706502 no 2934 0.142048609895775 4122 17118334
SGTC_1308 1187-1617 41.4 µM -1.07498723163971 0.126710824806861 no 2935 0.141190222462401 4182 2882570
SGTC_1090 efavirenz 20.7 µM -1.07706383533719 0.126287460554308 no 2936 0.140725874114099 4196 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2154 5570129 200 µM -1.07871645027978 0.125951241495451 no 2937 0.140357075021478 4211 673366
SGTC_3289 9119912 71.43 µM -1.07931634900522 0.125829348632504 no 2938 0.140223363570939 4218 17014829
SGTC_1888 azatryptophan 97.5 µM -1.08229037417669 0.125226274354852 no 2939 0.13956176090954 4222 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_889 0919-1524 82.7 µM -1.08252498669388 0.125178785544634 no 2940 0.13950965941866 4205 3905452
SGTC_1501 4491-0275 38.4 µM -1.08293631103729 0.125095558176626 no 2941 0.139418346643854 4147 5104718
SGTC_2942 9052777 62.25 µM -1.08626361390081 0.124423732351787 no 2942 0.138681190073275 4250 6469503
SGTC_290 2043-6722 48.1 µM -1.08831762730462 0.124010261913978 no 2943 0.138227455689904 4208 773758 YLR208W SEC13
SGTC_620 0109-0052 432 µM -1.09087269103597 0.123497273834138 no 2944 0.13766445257637 4188 493037
SGTC_787 4152-0075 138 µM -1.09204206031731 0.123262992403093 no 2945 0.137407307176568 4202 9566539
SGTC_2243 6634756 200 µM -1.0930012722399 0.123071048336002 no 2946 0.137196620578533 4251 885676
SGTC_3170 9103054 49.47 µM -1.09406605143677 0.122858225105169 no 2947 0.136963005155735 4164 16432970
SGTC_506 n9-isopropylolomoucine 153 µM -1.09643419865844 0.122385816222769 no 2948 0.136444402361769 4207 6610355
SGTC_3222 9128301 49.47 µM -1.09800283487468 0.122073600238207 no 2949 0.136101625694351 4197 4911358
SGTC_111 0083-0039 52.457 µM -1.09836460835027 0.122001673525702 no 2950 0.136022655066607 4061 759313
SGTC_1056 3448-1962 115 µM -1.09973607994629 0.121729271988076 no 2951 0.135723564850614 4189 715507
SGTC_1008 4106-0037 6 µM -1.10027731530985 0.121621889574012 no 2952 0.135605656416757 4184 2905394
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.10057887671696 0.121562087944846 no 2953 0.135539991542915 4203 5024745
SGTC_3030 9087619 49.47 µM -1.10343374617169 0.120996972242665 no 2954 0.134919424292186 4222 25236973
SGTC_2177 5811945 192 µM -1.10806754056214 0.120083661509456 no 2955 0.133916324017625 4258 5343475
SGTC_2439 5492030 7.2 µM -1.11247795773853 0.119218900874365 no 2956 0.132966351145589 4198 5722370
SGTC_224 benfluorex 43.875 µM -1.11484813418427 0.11875599500605 no 2957 0.132457752843748 4241 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1257 0669-0121 16 µM -1.11655096173003 0.118424210050347 no 2958 0.132093184451725 4215 4307855
SGTC_1720 st037298 9.481 µM -1.11982343375384 0.117788430708757 no 2959 0.131394505582036 4204 597396
SGTC_2476 5806916 10.51 µM -1.12085407617338 0.117588697465339 no 2960 0.131174990792127 4082 2870194
SGTC_1362 1611-0397 101 µM -1.12124310204819 0.117513368599625 no 2961 0.131092198716116 4177 27816
SGTC_577 r071-0003 38.6 µM -1.12174369570488 0.117416486628883 no 2962 0.130985716024156 4207 4568517 YMR134W ERG29
SGTC_3163 9099914 49.47 µM -1.121963107174 0.117374040848139 no 2963 0.130939063232806 4239 16268368
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.12383994500546 0.117011405143558 no 2964 0.13054046609722 4171 2333 A French combination drug.
SGTC_2062 5245942 200 µM -1.12681469466494 0.116438262660786 no 2965 0.129910418137524 4257 1376160
SGTC_2944 9067346 25.62 µM -1.12953347460453 0.115916181934525 no 2966 0.129336428309341 4172 6473075
SGTC_3104 9120930 49.47 µM -1.13624270176632 0.114634942718011 no 2967 0.127927501825419 4251 17014836
SGTC_1051 3253-3903 78 µM -1.13880286645918 0.114148702836371 no 2968 0.127392692986057 4205 5509239
SGTC_2919 7978188 46.38 µM -1.13894311166329 0.114122109237138 no 2969 0.127363441277828 4239 2980291
SGTC_1557 sumaresinolic acid 42.3 µM -1.14020622287084 0.113882794199252 no 2970 0.127100197781791 4212 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2418 pentamidine 31.67 µM -1.14407531055008 0.11315196453787 no 2971 0.126296202896437 4182 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2435 5706476 10.6 µM -1.14458753949126 0.113055461329626 no 2972 0.12619002818686 4221 5725375
SGTC_2371 9071574 200 µM -1.14459736604604 0.113053610594974 no 2973 0.126187991949003 4239 45596039
SGTC_2867 9039098 71.43 µM -1.14874170101703 0.112274992440286 no 2974 0.125331252542446 4204 6463460
SGTC_45 0kpi-0036 14.9 µM -1.14947267772994 0.112138058500737 no 2975 0.125180563346538 4275 2795021
SGTC_1875 nocodazole 6 µM -1.1520736017846 0.111651795318335 no 2976 0.124645414880447 4265 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1251 0490-5699 265 µM -1.15216615767852 0.111634519106391 no 2977 0.124626400718275 4288 3883818
SGTC_35 0133-0054 64.071 µM -1.15364667773179 0.111358429510779 no 2978 0.124322526583524 4244 99677
SGTC_1682 st012968 530 nM -1.15531999222843 0.111046976081406 no 2979 0.123979705980455 4269 24207270
SGTC_1620 st003704 16.5 µM -1.1578484138275 0.11057754621703 no 2980 0.123462951142629 4237 2834414
SGTC_726 3448-4391 34.2 µM -1.15806717599848 0.110536997521819 no 2981 0.123418311893267 4356 1356692
SGTC_870 0573-2213 57.6 µM -1.15863600191788 0.1104316126 no 2982 0.123302293735006 4234 3916321
SGTC_1384 3089-0840 101 µM -1.15941897731613 0.110286670601248 no 2983 0.123142722507438 4229 1069836
SGTC_1179 1021-1431 9.29 µM -1.15951761949783 0.110268419944871 no 2984 0.123122629395317 4263 2840958
SGTC_621 3584-0052 32.1 µM -1.16426134974108 0.109393295979509 no 2985 0.122159057326483 4274 2273927
SGTC_2004 4023728 41.89 µM -1.16517879831168 0.109224622249912 no 2986 0.12197331291844 4227 360084 YDR527W RBA50
SGTC_2336 9001819 198.65 µM -1.16756363222594 0.108787042828135 no 2987 0.121491413503501 4325 2989602
SGTC_3265 9137266 49.47 µM -1.16777160927204 0.108748942162401 no 2988 0.121449451465623 4207 17224265
SGTC_2669 eugenol 100 µM -1.16784161592066 0.108736119348671 no 2989 0.121435329018268 4258 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_603 3794-0023 45.9 µM -1.16799665454489 0.108707725467695 no 2990 0.121404057172754 4288 3802260
SGTC_327 1273-0057 3.96 µM -1.16805671105386 0.108696728109964 no 2991 0.121391945081435 4145 3108138
SGTC_1978 st071761 42 µM -1.16864085072779 0.108589804038864 no 2992 0.121274181136171 4289 5147680
SGTC_2457 5731572 11.68 µM -1.16870695701244 0.108577708355691 no 2993 0.121260859014458 4299 2865357
SGTC_2164 5685496 200 µM -1.17193539221464 0.107988169931712 no 2994 0.12061149811814 4185 759046
SGTC_475 α-linolenic acid 10 µM -1.17236889858458 0.107909184021888 no 2995 0.120524490329951 4263 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2368 9071271 200 µM -1.17544098859529 0.107350633737748 no 2996 0.11990916654961 4245 27209959
SGTC_3354 9151612 71.43 µM -1.17806536072542 0.106875138186687 no 2997 0.119385275093484 4275 27261949
SGTC_504 lovastatin 124 µM -1.17840152470352 0.106814340444062 no 2998 0.119318285082612 4288 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2091 4-phenylthiadiazole 200 µM -1.17870557186565 0.106759372761937 no 2999 0.119257718090311 4275 270010
SGTC_2766 oltipraz 83.91 µM -1.18034075289324 0.106464103859421 no 3000 0.118932357894792 4243 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2323 6148992 148.28 µM -1.18040504212902 0.106452507042906 no 3001 0.118919578762009 4236 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2272 7805186 180 µM -1.18246448164378 0.106081497407511 no 3002 0.118510725371653 4280 2956062 YPR165W RHO1
SGTC_2959 9079155 11 µM -1.18263950685426 0.106050009604547 no 3003 0.118476024080989 4300 16189457
SGTC_1849 st056239 19.2 µM -1.18513581107389 0.105601648349768 no 3004 0.117981877012946 4258 5393181
SGTC_615 k087-0205 167 µM -1.1904487609228 0.10465195589498 no 3005 0.116935028849504 4288 9642773
SGTC_2120 5538279 151.968 µM -1.19270931347079 0.10424976250111 no 3006 0.116491618424732 4235 2058197
SGTC_279 1273-0055 2.93 µM -1.19316782596725 0.104168321641538 no 3007 0.116401826252613 4305 2847562
SGTC_2119 5528445 120.635 µM -1.19718435448412 0.103456877932173 no 3008 0.115617353321465 4300 791935
SGTC_2810 7959871 45.46 µM -1.19748432963979 0.103403885512725 no 3009 0.115558915905917 4247 2974535
SGTC_128 0906-2981 13.371 µM -1.19853496503617 0.103218439795262 no 3010 0.115354409698571 4280 6740226
SGTC_1771 st048882 4.1505 µM -1.19959357574462 0.103031830743895 no 3011 0.115148611390937 4322 4580403
SGTC_602 3130-1533 38.1 µM -1.19997649456229 0.102964391231996 no 3012 0.115074234714301 4333 720941
SGTC_2254 7938975 95.19 µM -1.20015450996685 0.102933050150348 no 3013 0.115039669322259 4362 2969277
SGTC_958 1222-0007 33 µM -1.20335510559987 0.102370740897339 no 3014 0.114419466501892 4359 7312461
SGTC_3070 9117005 49.47 µM -1.20405698950229 0.102247726877809 no 3015 0.114283776164216 4371 8779016
SGTC_255 tunicamycin 200.472 nM -1.20790139846884 0.101575852604963 no 3016 0.113542595806238 4216 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2382 9035899 200 µM -1.20935710587981 0.101322284583199 no 3017 0.113262840188734 4281 6462679
SGTC_491 tetrandrine 80.3 µM -1.21012947257644 0.101187934306753 no 3018 0.113114607761187 4291 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2911 7942208 15.64 µM -1.21028218175111 0.101161386499176 no 3019 0.1130853162519 4325 1243384
SGTC_344 k064-0035 6.43 µM -1.21044102995651 0.101133776834957 no 3020 0.11305485294454 4236 5088750
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.21113465878569 0.101013280428796 no 3021 0.112921900053435 4322 6708561
SGTC_1525 8-methoxypsoralen 92.5 µM -1.21344537696384 0.100612620178303 no 3022 0.112479793164773 4339 4114 Related to psoralen; DNA damaging agent.
SGTC_2815 7968870 71.43 µM -1.21435630910728 0.100454990741874 no 3023 0.112305845885 4242 2977326 YHR190W ERG9
SGTC_3124 9127567 49.47 µM -1.21483135395845 0.100372859596872 no 3024 0.112215209873993 4276 17592030
SGTC_617 3770-0098 35 µM -1.21828813892556 0.0997766866682714 no 3025 0.111557247904009 4215 5962639
SGTC_1793 st048256 72.231 µM -1.21922835015664 0.0996149819213943 no 3026 0.111378767249135 4235 672022
SGTC_769 0302-0231 76 µM -1.21948520838581 0.09957083879375 no 3027 0.111330043319107 4207 571869 YER009W NTF2
SGTC_563 tetrahydrosecaminediol 614 µM -1.21967058957886 0.0995389884455839 no 3028 0.111294887486128 4351 334274 A psychoactive constituent of the cannabis plant.
SGTC_502 l-744,832 89.3 µM -1.22283424008874 0.0989965888637536 no 3029 0.110696155054921 4314 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2938 9059746 27.26 µM -1.22494232631857 0.0986363653238882 no 3030 0.110298475672461 4302 6471769
SGTC_1971 st069429 63.5 µM -1.22567315788357 0.0985117072260111 no 3031 0.110160847594108 4301 1246522 YGL099W LSG1
SGTC_2704 st078022 71.1 µM -1.22636553898184 0.0983937140705754 no 3032 0.110030574068975 4333 54697681
SGTC_938 3126-1755 342 µM -1.22707545132836 0.0982728407916338 no 3033 0.10989711679285 4299 1777771
SGTC_3008 9078912 71.4286 µM -1.2306381478317 0.0976678802267546 no 3034 0.109229115438158 4319 16648731
SGTC_2444 5485484 36.41 µM -1.23347582945804 0.0971879872336622 no 3035 0.108699144538904 4386 6790631
SGTC_1712 st032288 53.4 µM -1.23493063849446 0.0969426299816005 no 3036 0.10842815976726 4152 2883011
SGTC_3353 9151644 39.2805 µM -1.23736498363577 0.0965330890763289 no 3037 0.107975806266578 4332 4909158
SGTC_2763 lisinopril 49.32 µM -1.24075801923481 0.0959643858649922 no 3038 0.107347576934653 4230 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_266 formosanin C 406 nM -1.24144168431003 0.0958500963109394 no 3039 0.10722131416638 4165 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1747 st037496 66.6 µM -1.24235072006607 0.0956982862302709 no 3040 0.107053594685701 4284 723305
SGTC_2739 tacrine 100.86 µM -1.24264347200651 0.0956494339777992 no 3041 0.106999621488098 4373 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2972 9093619 59.92 µM -1.24465987633367 0.0953134498888217 no 3042 0.106628400335274 4274 25236256
SGTC_3057 9095946 49.47 µM -1.24816186613432 0.0947319959243974 no 3043 0.105985892944346 4375 24540043
SGTC_3108 9121785 49.47 µM -1.2483640377665 0.0946985082851036 no 3044 0.10594888627052 4150 17140271
SGTC_165 k038-0023 64.381 µM -1.24907621854015 0.0945806124082101 no 3045 0.105818598936365 4326 46368543
SGTC_2740 felodipine 17.08 µM -1.25063215840654 0.0943234153932803 no 3046 0.105534356127129 4368 3333 L-type calcium channel blocker
SGTC_2596 sinensetin 100 µM -1.25122933096988 0.0942248398070003 no 3047 0.10542540997602 4338 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_729 4092-0585 94.1 µM -1.25189484021507 0.0941150734041338 no 3048 0.10530409258471 4343 2169061
SGTC_760 0568-0725 82.9 µM -1.25246020876854 0.0940218979405142 no 3049 0.105201109471699 4353 3916171
SGTC_571 k831-0106 44.2 µM -1.25316632410886 0.0939056223439441 no 3050 0.105072591399509 4215 4783639
SGTC_381 3461-2219 42.7 µM -1.25687837877123 0.0932961055342574 no 3051 0.104398839416596 4321 2883159
SGTC_1513 0337-0559 19 µM -1.25727562897262 0.0932310508650404 no 3052 0.10432692286177 4308 775073
SGTC_192 3455-0609 60.9 µM -1.25872240075283 0.0929944072889779 no 3053 0.104065308700394 4399 3769639
SGTC_753 1322-0200 289 µM -1.26119996838921 0.092590191641281 no 3054 0.103618405020652 4403 5403907
SGTC_326 k292-0812 17.5 µM -1.26312023390978 0.0922777951026035 no 3055 0.103272986686624 4323 3579357
SGTC_2176 5809774 33.9695 µM -1.2645830160379 0.0920403477836384 no 3056 0.103010422250281 4266 2870539
SGTC_1380 2291-0730 164 µM -1.26733926701522 0.0915941669195482 no 3057 0.102517002838895 4354 2999191
SGTC_3349 9149703 23.001 µM -1.26789794714634 0.0915039236813157 no 3058 0.10241719865539 4358 4910494
SGTC_89 0302-0250 142.109 µM -1.26815534665774 0.0914623682864043 no 3059 0.102371239867625 4433 4203518 YLR208W SEC13
SGTC_2252 omeprazole 400 µM -1.26837298102176 0.0914272436176997 no 3060 0.102332392865876 4348 4594 A proton pump inhibitor.
SGTC_455 paf C-16 10 µM -1.26858755689776 0.0913926223573421 no 3061 0.102294102290902 4297 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2511 berberine 10.47 µM -1.26944308699544 0.0912546814139001 no 3062 0.102141538499043 4324 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_396 dithiazanine 1.25 µM -1.26947425786758 0.0912496585110287 no 3063 0.102135983029868 4334 10578 An antihelmenthic.
SGTC_413 propylparaben 100 µM -1.27116692600957 0.090977208133546 no 3064 0.10183463504825 4318 7175 A pharmaceutical preservative.
SGTC_2050 5263056 171 µM -1.2718331046811 0.0908701462430631 no 3065 0.101716212014681 4327 763468 YGL055W OLE1
SGTC_931 2812-0076 566 µM -1.28152521827198 0.0893230800572872 no 3066 0.10000462398046 4285 3450959
SGTC_103 0844-0104 51.839 µM -1.28195380691284 0.0892551234646972 no 3067 0.0999294255046371 4195 5375804
SGTC_2729 fluphenazine 10.66 µM -1.2836560720112 0.0889855937729086 no 3068 0.0996311605078375 4282 3372 An atypical antipsychotic.
SGTC_1503 4585-0012 61.3 µM -1.2860499648762 0.0886075803391592 no 3069 0.099212812301043 4385 2922052
SGTC_2456 5770359 74.46 µM -1.2867666552675 0.0884946425966335 no 3070 0.0990878162372998 4360 3118787
SGTC_1150 3909-7983 10.9 µM -1.28697209970899 0.0884622879685266 no 3071 0.0990520064691253 4345 23965914
SGTC_1956 st077085 54 µM -1.28882869243808 0.0881703001750122 no 3072 0.0987288243285479 4393 24208685
SGTC_3324 9138759 60.749 µM -1.29506290656278 0.0871950966834019 no 3073 0.0976492648101779 4394 45595710
SGTC_723 4182-0001 115 µM -1.29799635115254 0.0867390210428258 no 3074 0.0971442944114822 4378 744821 YLR208W SEC13
SGTC_3089 9117425 49.47 µM -1.30005986928943 0.0864192664069938 no 3075 0.0967902252690274 4344 9401657
SGTC_1124 fisetin 1.16336 µM -1.30102112413286 0.0862706154046413 no 3076 0.0966256121049664 4369 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2482 5981709 142.65 µM -1.30562167739653 0.0855618206046896 no 3077 0.0958406224054776 4298 877755
SGTC_2258 7960471 200 µM -1.30713039906587 0.0853303280422673 no 3078 0.0955842142962393 4373 2974708
SGTC_2049 5262831 67.185 µM -1.31276408309508 0.0844700630636034 no 3079 0.0946312281272622 4341 763417
SGTC_474 dl-dihydrosphingosine 5 µM -1.31310681160653 0.0844179390618447 no 3080 0.0945734794555873 4380 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2620 irigenin 100 µM -1.32017043373434 0.083349032645316 no 3081 0.093389060490372 4381 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.32249835754436 0.0829989966733239 no 3082 0.0930011279640228 4377 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1694 st024011 44.9 µM -1.32449210421674 0.0827000889036105 no 3083 0.0926698318182102 4415 2787533
SGTC_536 3852-0578 10.6 µM -1.32579255029916 0.0825055595732596 no 3084 0.0924542106426197 4417 2869208
SGTC_2356 9061756 188.97 µM -1.32592582302083 0.082485643233822 no 3085 0.0924321342739939 4421 20104043
SGTC_3059 1327-0034 3 µM -1.32955801749853 0.0819442388781171 no 3086 0.0918319691243995 4233 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3041 9091929 49.47 µM -1.33257721447272 0.081496247755146 no 3087 0.0913352933572744 4387 25236887
SGTC_2971 9092186 9.93 µM -1.34018924690041 0.0803749688552736 no 3088 0.0900919133245714 4357 25236400
SGTC_649 1123-0311 367 µM -1.34250424323469 0.0800362840594951 no 3089 0.0897162777401461 4309 693629 YIL048W NEO1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.34326025788797 0.0799259128897391 no 3090 0.0895938579703324 4393 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_263 alizarin 107.927 µM -1.34346074305762 0.0798966632199714 no 3091 0.0895614147002491 4439 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_233 rapamycin 362 pM -1.34495836186776 0.0796784250052432 no 3092 0.0893193406801488 4387 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2495 cafestol 54.53 µM -1.34562118549301 0.0795819801336607 no 3093 0.0892123578748335 4411 16667697 An anti-infammatory.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.34640192072662 0.0794684917335891 no 3094 0.0890864659222662 4357 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2283 7944793 200 µM -1.34666022001391 0.07943097208522 no 3095 0.0890448448140266 4396 2970533
SGTC_2989 9073649 71.4286 µM -1.34993169880108 0.0789569281130155 no 3096 0.0885189463159856 4379 21367202
SGTC_2038 4100038 30.985 µM -1.35542366330841 0.0781659540475859 no 3097 0.0876413073054174 4384 3596803
SGTC_601 0986-0029 62.9 µM -1.35675680800556 0.0779748590120138 no 3098 0.0874292477770189 4363 24747981
SGTC_3 0833-0587 95.581 µM -1.36032997159942 0.0774644245730401 no 3099 0.0868627639739785 4283 5382644
SGTC_572 0960-0087 17.7 µM -1.367609010299 0.0764324531299146 no 3100 0.0857172472907923 4371 6796365
SGTC_1258 0671-0043 57.1 µM -1.36906872679103 0.0762267695289554 no 3101 0.0854888964031176 4423 4298767
SGTC_99 0109-0120 622.8 µM -1.37926667648164 0.074801546429151 no 3102 0.0839062734470046 4427 759414
SGTC_426 0988-0037 14.6 µM -1.38073856306948 0.0745975317489405 no 3103 0.0836796798292034 4454 5383008
SGTC_3125 9127534 49.47 µM -1.38204117288805 0.074417334596679 no 3104 0.0834795297199928 4331 1639235
SGTC_2982 9019404 25.97 µM -1.38213239157102 0.0744047282783369 no 3105 0.0834655271726849 4359 22333232
SGTC_1767 st044992 70.3 µM -1.38393834052209 0.0741554837350127 no 3106 0.0831886678141715 4475 9600693
SGTC_541 4513-1321 94 µM -1.38407960452292 0.0741360143838504 no 3107 0.0831670406194953 4381 747515
SGTC_1216 1165-0504 9.65 µM -1.38408760377484 0.0741349120241477 no 3108 0.0831658160788605 4452 6304004
SGTC_1691 st019933 84.6 µM -1.39241161626322 0.0729945693353265 no 3109 0.0818988944259727 4406 6176082
SGTC_2512 diallyl trisulfide 49.23 µM -1.39433133756007 0.0727334934759508 no 3110 0.0816087859605873 4476 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1035 k081-0041 55.2 µM -1.39590474018948 0.072520049492037 no 3111 0.0813715915206914 4447 731709
SGTC_1735 st034310 56.75 µM -1.39706489945633 0.0723629726741974 no 3112 0.0811970279167435 4464 871153
SGTC_1327 1436-0082 2.18 µM -1.40053667094889 0.0718944781542308 no 3113 0.0806763350357136 4448 15992205
SGTC_470 aa-861 153 µM -1.40582782292951 0.0711849476879081 no 3114 0.0798876290144071 4395 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3194 9111903 49.47 µM -1.40716394912483 0.0710066295264952 no 3115 0.0796893894921283 4439 17087251
SGTC_2469 5655019 90.81 µM -1.41064440253551 0.0705437422763851 no 3116 0.0791747460423665 4494 2788239
SGTC_1050 3232-1156 69.3 µM -1.42308724648758 0.0689078438472875 no 3117 0.0773554324943447 4412 700529
SGTC_3334 9142812 21.919 µM -1.42599737649578 0.068529493163537 no 3118 0.0769345496704411 4457 45283678
SGTC_2991 9074669 71.4286 µM -1.42695636715034 0.0684051649154016 no 3119 0.0767962359137893 4408 17333109
SGTC_716 1683-5115 658 µM -1.42714055128043 0.0683813063165813 no 3120 0.0767696929742912 4441 723597
SGTC_1955 wogonin 32.4 µM -1.42797923908806 0.0682727466676381 no 3121 0.076648917117236 4456 5281703 A flavanone.
SGTC_2724 maprotiline 69.64 µM -1.4328221745463 0.067648477293351 no 3122 0.0759543313055455 4396 4011 A tricyclic antidepressant.
SGTC_2899 9053889 58.44 µM -1.43296145610047 0.0676305889280259 no 3123 0.0759344263356424 4438 6470052
SGTC_2687 chenodiol 100 µM -1.43373180139087 0.0675317170715866 no 3124 0.0758244066778285 4493 5702181 A cholesterol synthesis inhibitor.
SGTC_63 0099-0242 26.702 µM -1.43529098950023 0.0673319411115132 no 3125 0.075602097162474 4471 3898502 YLR359W ADE13
SGTC_1464 k208-0027 110 µM -1.44324200980049 0.0663202884225538 no 3126 0.0744761545970727 4460 X1464
SGTC_361 000s-0510 1.45 µM -1.44427277839616 0.0661900044436873 no 3127 0.0743311299336347 4363 660
SGTC_1295 1013-0063 9.78 µM -1.45239576800616 0.0651702255794805 no 3128 0.0731957961773385 4483 6826038
SGTC_1442 4112-3290 3 µM -1.45325249842905 0.0650633843040342 no 3129 0.0730768304043498 4464 704353
SGTC_1820 st053765 18.6 µM -1.45426156376508 0.0649377200254399 no 3130 0.0729369012110107 4483 3690829
SGTC_759 3486-0358 89.3 µM -1.45728257554774 0.0645626236194225 no 3131 0.0725191973083569 4456 875103
SGTC_1047 2043-3044 82 µM -1.45739423967095 0.0645487914440009 no 3132 0.0725037931219686 4448 669592
SGTC_3262 9137218 49.47 µM -1.45758515171721 0.0645251479192896 no 3133 0.0724774624052644 4439 17650664
SGTC_538 2922-0838 53.3 µM -1.45959795342909 0.064276281462098 no 3134 0.0722003010308944 4490 777039
SGTC_2703 st077852 53.4 µM -1.45960210306533 0.0642757691651931 no 3135 0.0721997304692012 4511 6281836
SGTC_2833 9001315 45.46 µM -1.46260543592081 0.063905821715109 no 3136 0.0717876874812831 4419 2989378
SGTC_2858 9025781 8.96 µM -1.46452054823537 0.0636707861507976 no 3137 0.071525886428388 4320 4894980 YPL153C RAD53
SGTC_2207 7258803 200 µM -1.47063578131518 0.0629247840017806 no 3138 0.070694820944389 4495 3666799
SGTC_1922 5578187 25 µM -1.47656466595124 0.0622080331245527 no 3139 0.0698961845558312 4480 1350412
SGTC_822 1487-0950 154 µM -1.47702249599919 0.0621529513909579 no 3140 0.069834803584275 4480 1958375
SGTC_1026 k007-1105 30.6 µM -1.47703023774759 0.0621520203050493 no 3141 0.0698337660099844 4447 7066794
SGTC_1285 0929-0069 65.5 µM -1.48217382032055 0.0615358126777737 no 3142 0.0691470252914255 4521 1206237
SGTC_1189 1431-2119 7.28 µM -1.4842248101388 0.0612914362163204 no 3143 0.0688746449601066 4469 3107275
SGTC_1930 st074634 34.3 µM -1.48467641275225 0.0612377295358228 no 3144 0.0688147814411311 4399 684253 YOR116C RPO31
SGTC_865 0488-0499 301 µM -1.489410589051 0.0606769302234182 no 3145 0.0681896409304683 4434 9634651
SGTC_2374 9071832 200 µM -1.49718940105942 0.0597642028268648 no 3146 0.067171991224644 4432 17381698
SGTC_705 1124-0212 310 µM -1.50720430216754 0.0586049837153569 no 3147 0.0658791489318209 4494 9554485
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.50797600751642 0.0585163969008087 no 3148 0.0657803338477753 4520 6710655
SGTC_2745 rifampicin 24.3 µM -1.50814255387587 0.0584972922504148 no 3149 0.0657590230522389 4593 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2 0422-0095 29 µM -1.508464280564 0.0584604006241837 no 3150 0.065717870980841 4413 6790840
SGTC_1813 st051246 8.6015 µM -1.51110234713993 0.0581585885744944 no 3151 0.0653811884031091 4454 5291959
SGTC_1642 st009582 77.7 µM -1.51153290400854 0.0581094464716982 no 3152 0.0653263659187596 4495 6739311
SGTC_3160 9100216 49.47 µM -1.51351111542505 0.0578840802523046 no 3153 0.0650749399336877 4486 17191039
SGTC_1305 1181-0477 144 µM -1.5136744689584 0.0578655010790289 no 3154 0.0650542117010563 4549 6252086
SGTC_2481 5478948 45.16 µM -1.51559913075895 0.0576469506285755 no 3155 0.0648103735006956 4501 77792
SGTC_724 3910-0327 137 µM -1.52144442787611 0.0569871794900461 no 3156 0.0640741734909889 4527 2885483
SGTC_209 4077-0173 175.592 µM -1.5375914157328 0.0551955063648149 no 3157 0.0620742738441995 4489 15993494
SGTC_439 amiodarone 34.4 µM -1.53772055635561 0.05518135836353 no 3158 0.0620584776282896 4385 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2925 9010536 32.5 µM -1.53885762681708 0.0550569102263764 no 3159 0.0619195288534365 4434 2994177
SGTC_2881 9058953 51.95 µM -1.54172795467118 0.0547437498302638 no 3160 0.0615698579156627 4481 17122249
SGTC_2583 asiatic acid 100 µM -1.54286729487891 0.0546198358738633 no 3161 0.061431488758101 4521 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1365 1672-3266 55.4 µM -1.54470538299614 0.0544203941511616 no 3162 0.0612087711193855 4536 6415873
SGTC_2349 9023730 187.07 µM -1.54526378150846 0.0543599193455442 no 3163 0.061141236138947 4546 4126287
SGTC_2054 5233173 129 µM -1.54812029878069 0.0540513884396908 no 3164 0.0607966678726251 4517 6889
SGTC_3105 9121040 49.47 µM -1.54936025642419 0.0539178934353048 no 3165 0.0606475710617742 4487 41448907
SGTC_998 3996-0085 177 µM -1.55232303125711 0.0535999752965911 no 3166 0.0602924749002503 4548 715391
SGTC_2955 9076254 12.21 µM -1.55682714305566 0.0531195120820266 no 3167 0.0597557654940142 4452 16459619
SGTC_2721 ifenprodil 61.44 µM -1.56143760786524 0.0526312471016066 no 3168 0.0592102671283225 4514 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_612 0302-0167 22.4 µM -1.5615685806871 0.0526174288055591 no 3169 0.059194827996003 4527 235821
SGTC_984 1492-0255 2.91 µM -1.56174719256818 0.0525985889881875 no 3170 0.0591737782397442 4490 1585198
SGTC_1928 4'-methoxychalcone 40.3 µM -1.5676821960979 0.0519756091937483 no 3171 0.0584776593551712 4531 641818
SGTC_1041 0206-0046 107 µM -1.57308696610135 0.0514134001130608 no 3172 0.0578493412584951 4545 50494
SGTC_2557 derrustone 83.84 µM -1.57368161822616 0.0513518403450815 no 3173 0.0577805367692481 4503 629853 An antioxidant.
SGTC_860 0443-0016 25.1 µM -1.58143632928398 0.0505544108623649 no 3174 0.0568891531756184 4550 5337942
SGTC_660 4031-1742 102 µM -1.58201940506559 0.0504948532074088 no 3175 0.056822570319506 4411 6738706
SGTC_3297 9117502 71.43 µM -1.58249227792251 0.0504465931745069 no 3176 0.0567686168900079 4556 7453720
SGTC_2918 7977171 22.06 µM -1.58547221777977 0.050143314114883 no 3177 0.0564295421545909 4521 2236483
SGTC_3187 9109394 49.47 µM -1.58555687220784 0.0501347198126226 no 3178 0.0564199330533176 4545 17098090
SGTC_1424 4048-1941 275 µM -1.58592649207005 0.050097208954116 no 3179 0.0563779927099629 4608 X1424
SGTC_522 1273-0010 11.6 µM -1.59433400525197 0.0492500003979195 no 3180 0.055430622566054 4545 5705015
SGTC_2980 9014342 25.29 µM -1.59602028651792 0.0490814625064184 no 3181 0.0552421320796746 4563 2996599
SGTC_1602 st001878 87.6 µM -1.60086378579647 0.0485999327614565 no 3182 0.0547035460481673 4518 595405 YLR310C CDC25
SGTC_2438 5259590 200 µM -1.6013976804118 0.0485470860778444 no 3183 0.0546444330909266 4558 1201127
SGTC_779 1360-0071 233 µM -1.60296001313201 0.0483927050498268 no 3184 0.0544717413061905 4567 7566
SGTC_664 1222-0054 14.9 µM -1.60847611034615 0.0478507731838113 no 3185 0.0538654721232617 4520 6813991
SGTC_1977 st070720 65.3 µM -1.60904259810047 0.0477953945027434 no 3186 0.0538035136966274 4570 682188
SGTC_2571 chrysanthemic acid 100 µM -1.60915531056497 0.0477843820866734 no 3187 0.0537911927380817 4539 2743 An insecticide.
SGTC_1952 st077036 64.1 µM -1.61054467746665 0.0476488027136402 no 3188 0.0536395000706592 4568 2937007
SGTC_1603 st002045 67.8 µM -1.61428538004523 0.0472853026504687 no 3189 0.053232769891508 4536 5887985
SGTC_1377 2944-0135 198 µM -1.61974303092186 0.0467589496976948 no 3190 0.0526437442396636 4557 1894137
SGTC_254 nsc-64875 3.808 µM -1.62365283735831 0.0463847734622542 no 3191 0.0522249609585945 4559 56993
SGTC_2073 5212005 126 µM -1.62487942864683 0.0462678828474405 no 3192 0.0520941261368191 4487 691789
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.62571721760083 0.0461881800109463 no 3193 0.0520049128111687 4576 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1444 4112-3581 28 µM -1.62936939352441 0.0458420183774613 no 3194 0.0516174219788995 4641 2877249
SGTC_668 1682-0499 62.6 µM -1.63303003166219 0.0454971498570057 no 3195 0.0512313403161171 4551 682214
SGTC_473 2-arachidonoylglycerol 10 µM -1.63575852426655 0.0452414582197932 no 3196 0.0509450677935034 4412 5282280 An endocannabinoid.
SGTC_2868 9035608 32.47 µM -1.63956586789838 0.04488659913322 no 3197 0.050547732392068 4558 6462614
SGTC_2555 cholic acid 100 µM -1.64030967706065 0.0448175355927829 no 3198 0.0504703972820933 4539 6708657 Influences liver metabolism.
SGTC_763 3453-1109 128 µM -1.64351686759538 0.0445207234808614 no 3199 0.050138019171978 4586 1560353
SGTC_3073 9114972 49.47 µM -1.64421533007284 0.0444562941453605 no 3200 0.0500658657231797 4577 41905075
SGTC_1364 1653-0028 37.6 µM -1.64465388879941 0.0444158779152584 no 3201 0.0500206035064365 4575 5718652
SGTC_1129 3453-1384 223 µM -1.6484943173165 0.0440632192514422 no 3202 0.0496256379302088 4554 1084452
SGTC_2231 micatex 6.853 µM -1.65281199705693 0.0436694353173452 no 3203 0.0491845658436794 4590 20737 An antifungal of unknown mechanism.
SGTC_3096 9117468 49.47 µM -1.6580871274092 0.0431921886951333 no 3204 0.0486499408644668 4534 41316311
SGTC_3175 9106517 49.47 µM -1.66230037724014 0.0428140449417027 no 3205 0.0482262811052603 4593 41468073
SGTC_258 haloperidol 50.781 µM -1.6696975351626 0.0421566180258347 no 3206 0.0474896108370971 4557 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3168 9103419 49.47 µM -1.6712527358886 0.0420194432984322 no 3207 0.0473358838898933 4610 16649256
SGTC_3323 9138564 53.9225 µM -1.67293306601863 0.0418716379926276 no 3208 0.0471702367434083 4599 43912313 YNL103W MET4
SGTC_2675 theaflavin digallate 100 µM -1.67350970539021 0.0418210127292971 no 3209 0.0471134987732597 4514 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_117 lucigenin 22.078 µM -1.67359347697101 0.0418136622432509 no 3210 0.0471052606890187 4535 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2125 5246583 200 µM -1.67846649537876 0.0413878794958863 no 3211 0.0466280329487779 4585 835267
SGTC_1033 k072-0102 21.3 µM -1.68451764444537 0.0408640550451317 no 3212 0.0460408362087202 4532 5965931
SGTC_102 gallobenzophenone 83.616 µM -1.68718493616707 0.0406348721967551 no 3213 0.0457838985129717 4559 70837
SGTC_1660 st012960 28.1 µM -1.68732534756289 0.0406228365312421 no 3214 0.0457704048095088 4593 24207266
SGTC_3284 9108171 64.8615 µM -1.68941481575359 0.0404440749187964 no 3215 0.0455699818571282 4562 8687505
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.6920544587418 0.0402191575165203 no 3216 0.0453177952911331 4558 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2075 5212009 200 µM -1.70069658656098 0.0394898828092161 no 3217 0.0444999882155016 4524 780898
SGTC_1414 3917-0015 5.4 µM -1.70606702674329 0.0390421372556364 no 3218 0.0439978004337093 4584 6618702
SGTC_3237 9133362 49.47 µM -1.70621920588588 0.0390295102109344 no 3219 0.0439836370829119 4570 43845137
SGTC_3075 9116269 49.47 µM -1.70719427942296 0.0389486824943076 no 3220 0.0438929739790994 4586 17015205 YNL244C SUI1
SGTC_1554 st069299 38.7 µM -1.7093582295607 0.0387697909469752 no 3221 0.0436923066298486 4552 24207999
SGTC_1784 st039334 36.3 µM -1.71150008988296 0.0385933851999344 no 3222 0.0434944173029217 4596 3496984
SGTC_435 c-PAF 6.7 µM -1.71966353531833 0.0379270236503922 no 3223 0.0427468098996133 4511 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_236 1509-0011 5.31 µM -1.72550261648246 0.0374561767063987 no 3224 0.0422184663346031 4611 3107280
SGTC_2179 6298986 200 µM -1.72915578858806 0.0371640306173908 no 3225 0.0418906083233735 4557 738374
SGTC_2777 climbazole 1.536 µM -1.7328790200806 0.0368682004722769 no 3226 0.0415585869834095 4400 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_211 3455-0679 143.504 µM -1.73319285068029 0.036843353231828 no 3227 0.0415306986610645 4574 748649
SGTC_1647 st011722 22.4 µM -1.73460394426613 0.0367318003791472 no 3228 0.0414054901942831 4604 2854783
SGTC_699 0375-0592 111 µM -1.73953107544308 0.0363444544109697 no 3229 0.0409706955111616 4666 762578
SGTC_530 4358-1714 28 µM -1.74224839339979 0.0361322670949378 no 3230 0.040732494670688 4591 1564641
SGTC_95 0471-0001 561.058 µM -1.74258711347136 0.0361058886953259 no 3231 0.0407028813085973 4578 4015405
SGTC_1166 k206-0078 225 µM -1.74723589914963 0.0357454475094887 no 3232 0.0402982134835166 4626 5404595
SGTC_2203 7227154 166.4 µM -1.75602212975778 0.035072265722293 no 3233 0.0395423149981299 4626 896304
SGTC_2837 9008476 45.46 µM -1.75960986657643 0.0348003891153054 no 3234 0.0392369887362295 4571 2992805
SGTC_1194 1488-0194 225 µM -1.77083257757279 0.0339610911581423 no 3235 0.0382942734049021 4614 1391452
SGTC_68 0986-0284 82.829 µM -1.77355144396072 0.0337602837993882 no 3236 0.0380686876965975 4562 423278 YIL048W NEO1
SGTC_420 mitomycin C 81.9 mM -1.77841010361268 0.0334038708440202 no 3237 0.0376682622420421 4606 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1438 4092-1045 4 µM -1.77895308668014 0.0333642328297946 no 3238 0.0376237267911602 4646 1351342
SGTC_173 1273-0061 2.693 µM -1.77926927816574 0.0333411685551581 no 3239 0.03759781258877 4558 2847414 YPL266W DIM1
SGTC_415 dibenzyl ketone 100 µM -1.79135141677402 0.0324696377096435 no 3240 0.0366184599845229 4606 7593
SGTC_2015 5119600 184 µM -1.79165379312161 0.0324480695406485 no 3241 0.0365942202524255 4598 2828786
SGTC_288 1315-0019 35.1 µM -1.79173534414211 0.0324422546211362 no 3242 0.0365876850351369 4654 6811474
SGTC_880 0833-0487 87.2 µM -1.79340784050186 0.0323231883222709 no 3243 0.0364538674077344 4615 76075
SGTC_3259 9138485 49.47 µM -1.79464960374148 0.0322350196995043 no 3244 0.0363547723372326 4591 17646153
SGTC_683 panaxydol 45 µM -1.79759974544362 0.0320263472759063 no 3245 0.0361202293621951 4640 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1406 3909-7906 11.9 µM -1.80685279377439 0.0313790755701278 no 3246 0.0353926172825823 4656 X1406
SGTC_1428 4049-0204 61.7 µM -1.8093665254076 0.0312051147789445 no 3247 0.0351970400352833 4668 X1428
SGTC_1605 st000082 49.1 µM -1.810323613233 0.0311390903048649 no 3248 0.0351228086439126 4599 1114022
SGTC_1264 0783-0040 158 µM -1.81200593344503 0.031023315959299 no 3249 0.0349926398509336 4544 2855798
SGTC_1354 1498-1681 81 µM -1.82365231460987 0.0302315640362603 no 3250 0.0341023261177619 4664 5754243
SGTC_411 enrofloxacin 100 µM -1.82827596826022 0.0299219149659525 no 3251 0.0337540723164789 4666 71188 A bacterial gyrase inhibitor.
SGTC_1233 0325-0408 14.2 µM -1.82955184783995 0.0298369330725771 no 3252 0.0336584898239713 4651 12874
SGTC_696 1560-0013 611 µM -1.83265497106744 0.029631080225045 no 3253 0.0334269488297258 4651 1650269
SGTC_2764 methyldopa 94.69 µM -1.83450037073953 0.0295092212313418 no 3254 0.033289876406643 4594 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_771 0250-0039 27.3 µM -1.83553359622404 0.0294411751513392 no 3255 0.0332133329504934 4594 3005115
SGTC_2030 5175110 200 µM -1.8405157279848 0.0291148883767854 no 3256 0.0328462786700878 4637 2831986
SGTC_1191 1487-1166 10.6 µM -1.84202863114309 0.0290164029539754 no 3257 0.0327354809961823 4647 3955771
SGTC_1572 epiandrosterone 68.9 µM -1.84388710186656 0.0288958011957753 no 3258 0.0325997976003921 4605 441302 A steroid.
SGTC_686 1319-0111 510 µM -1.84878547007636 0.0285799263269983 no 3259 0.0322443981231116 4649 4562600
SGTC_2408 sulbentine 18.36 µM -1.85367166331039 0.0282677032727729 no 3260 0.0318930740517764 4514 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_73 0327-0325 16.231 µM -1.85692648766894 0.02806130262367 no 3261 0.0316608067647632 4462 53298
SGTC_3093 9117344 49.47 µM -1.86201343279392 0.0277412346536977 no 3262 0.0313005984170882 4667 24824913
SGTC_133 0724-0033 378.92 µM -1.87278532127546 0.0270735074036508 no 3263 0.0305490178768309 4588 280309
SGTC_739 1486-1183 203 µM -1.87887828927175 0.0267017922998371 no 3264 0.0301305569671661 4652 4346692
SGTC_362 0310-0100 9.03 µM -1.88863845426898 0.0261152394819839 no 3265 0.0294701453087106 4658 790235
SGTC_395 anisomycin 6.25 µM -1.89594505557487 0.0256832237148241 no 3266 0.0289836551504999 4660 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1012 4112-3522 18 µM -1.90894354061623 0.0249294537987283 no 3267 0.0281346876998359 4658 3112398
SGTC_1804 st050076 49.1 µM -1.90949474860068 0.0248979041445059 no 3268 0.0280991492631472 4683 3895976
SGTC_3004 9076122 71.4286 µM -1.91364767172043 0.0246612768740656 no 3269 0.0278325947273535 4649 44782551
SGTC_2253 7938677 135.83 µM -1.91440979499896 0.0246180577966174 no 3270 0.0277839074933323 4677 2301972
SGTC_1559 coumarin 343 70.1 µM -1.92597052107402 0.0239702194034622 no 3271 0.0270540274046017 4695 108770 A hepatotoxic, DNA x-linker.
SGTC_112 phenothiazine 287.218 µM -1.92637369441277 0.0239478874469508 no 3272 0.027028864809228 4637 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2752 diclazuril 33.15 µM -1.92887399392546 0.0238097848175099 no 3273 0.0268732535233227 4585 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1252 0493-0875 34.8 µM -1.92940096593819 0.0237807634012289 no 3274 0.0268405519486982 4635 3960963
SGTC_2929 9013348 24.6 µM -1.93283618356698 0.0235923069390462 no 3275 0.0266281906861994 4633 2995952
SGTC_3145 9085516 49.47 µM -1.9364443970894 0.0233957141094653 no 3276 0.0264066481766193 4636 25236195
SGTC_1434 4073-0095 163 µM -1.95627497556402 0.0223396946563116 no 3277 0.0252163852222515 4684 24133745
SGTC_2220 6782180 200 µM -1.97108215244075 0.0215776549750584 no 3278 0.0243572399095559 4669 833803
SGTC_462 ag-879 158 µM -1.97522278705648 0.0213685328332731 no 3279 0.0241214355342339 4666 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1765 st044815 90.4 µM -1.97984018953388 0.021137355100832 no 3280 0.0238607444162499 4687 645695
SGTC_495 decylubiquinone 155 µM -1.9815396366605 0.0210528038762145 no 3281 0.0237653944660126 4680 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1701 st028638 40.4 µM -1.98673646345483 0.0207960239069828 no 3282 0.0234758044000959 4681 3490878
SGTC_2409 alverine citrate 63.97 µM -1.98796599230091 0.020735661178868 no 3283 0.0234077256228111 4653 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2045 5106652 78.05 µM -1.9975754593278 0.0202689839333396 no 3284 0.0228813530076892 4684 673349
SGTC_3142 9086498 49.47 µM -2.04772672190514 0.0179754455417952 no 3285 0.0202933919895671 4581 25236367
SGTC_2286 7945697 125 µM -2.05855872368941 0.0175102450959507 no 3286 0.0197682651534632 4657 1245733
SGTC_350 k064-0020 19.8 µM -2.07043199183067 0.0170121717086204 no 3287 0.0192059542732437 4691 2790705
SGTC_1953 st076800 12.1 µM -2.08498489797324 0.016418254040795 no 3288 0.0185353356984534 4664 297591
SGTC_1353 1498-1206 8.11 µM -2.08969928343089 0.0162297023771274 no 3289 0.0183224107130203 4710 6756808
SGTC_1441 4106-0040 13 µM -2.09444934030666 0.0160416031512134 no 3290 0.0181099856994024 4746 2904180
SGTC_1941 st076221 61.8 µM -2.0946296410073 0.0160345003190379 no 3291 0.0181019640854016 4623 2828568
SGTC_566 0958-0068 16.5 µM -2.10524094622971 0.0156211954229407 no 3292 0.0176351698330782 4644 6815365
SGTC_1715 st032160 10.2275 µM -2.10825885706715 0.0155053321316556 no 3293 0.0175043023419864 4635 5289825
SGTC_93 0109-0045 59.227 µM -2.11336107893734 0.0153111257379652 no 3294 0.0172849372915355 4758 88733
SGTC_912 3474-0017 2.18 µM -2.11635905315463 0.0151979907525806 no 3295 0.0171571409012584 4698 3360550
SGTC_2563 tomatine 8.54 µM -2.11774607557873 0.0151458919456816 no 3296 0.0170982892110872 4641 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_873 0591-4978 488 µM -2.13004486900127 0.0146906045277125 no 3297 0.0165839546008065 4715 3305145
SGTC_1787 fluconazole 80 µM -2.13694048614619 0.0144405253733719 no 3298 0.0163014162508513 4366 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_848 0368-0089 85.6 µM -2.13742712634033 0.0144230159712379 no 3299 0.0162816335231216 4707 762535
SGTC_147 4466-0538 29.23 µM -2.13747578199089 0.0144212663376776 no 3300 0.0162796567217749 4694 6742687 YHR072W ERG7
SGTC_2988 9073640 71.4286 µM -2.13968098117493 0.0143421600361683 no 3301 0.0161902785435915 4695 9102229
SGTC_2217 6934799 96.0675 µM -2.1431355560126 0.0142189865977539 no 3302 0.016051107565579 4708 675606
SGTC_840 0245-0196 390 µM -2.14906333642635 0.0140097535754682 no 3303 0.0158146897951991 4757 3827528
SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.16720369810198 0.0133858595252927 no 3304 0.0151096627687006 4725 165506
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.1731491269744 0.0131866701390755 no 3305 0.014884547619326 4672 676296 Flavone; oxidizing agent.
SGTC_2965 9082772 38.63 µM -2.1977236606913 0.0123902847634423 no 3306 0.0139844021929871 4691 16459634
SGTC_3310 9130229 44.1445 µM -2.22511955076915 0.0115518954807069 no 3307 0.0130366068038253 4714 7761258
SGTC_425 3825-7017 13.1 µM -2.24739317864675 0.0109070106159968 no 3308 0.0123074552864557 4716 3397440
SGTC_1058 3448-5425 97.3 µM -2.25757306587429 0.0106228586255093 no 3309 0.011986144717278 4704 7279705
SGTC_862 0452-0056 10.2 µM -2.26317085558708 0.0104693718073963 no 3310 0.0118125795320417 4716 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_417 st075190 100 µM -2.26685010180172 0.0103695456787549 no 3311 0.0116996921458614 4733 222757
SGTC_444 curcumin 90.4 µM -2.26795860114698 0.0103396327463937 no 3312 0.0116658650250817 4655 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1861 st057647 17.4 µM -2.28682297229082 0.00984198925541156 no 3313 0.0111030790299743 4736 688668
SGTC_1020 4335-0961 93.3 µM -2.33578153578781 0.00864683578557151 no 3314 0.00975131521095885 4721 669075
SGTC_57 miconazole 162.5 nM -2.36237012867329 0.00805269071699501 no 3315 0.00907925127571441 4627 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3017 9080681 49.47 µM -2.36677336397914 0.00795783979304535 no 3316 0.00897195861468722 4746 16451914
SGTC_500 h-89 112 µM -2.41651538647369 0.00695267909813604 no 3317 0.00783493197378927 4732 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2116 5511452 16.8835 µM -2.41921914256878 0.00690140671298568 no 3318 0.00777693335942193 4764 870744
SGTC_806 3966-4455 5.86 µM -2.42692984563228 0.0067570148969781 no 3319 0.00761360001288711 4753 714982
SGTC_1738 st035555 74 µM -2.44458707855544 0.00643637509875231 no 3320 0.00725090340998712 4739 5331140
SGTC_876 0720-0963 56.8 µM -2.45720071678235 0.00621563990227761 no 3321 0.00700122140797212 4766 765861
SGTC_1578 josamycin 24.2 µM -2.48400545639208 0.00576869817503232 no 3322 0.00649569086978562 4759 5282165 A P450 substrate.
SGTC_2485 5633444 17.78 µM -2.50706269159535 0.00540730687336704 no 3323 0.00608695588152662 4730 5724239
SGTC_230 MPP+ 141.667 µM -2.53232611423691 0.00503456939088023 no 3324 0.00566542769671058 4768 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1451 4152-0210 104 µM -2.5490394616192 0.00480072900682859 no 3325 0.00540100383147694 4775 659563
SGTC_339 3091-4833 71.4 µM -2.55920339190804 0.00466330462992512 no 3326 0.00524561701527863 4623 3240077
SGTC_1550 gossypolone 36.6 µM -2.56046883883932 0.00464644283791383 no 3327 0.00522655186620273 4779 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_537 1334-0398 209 µM -2.59002682614576 0.00426775749670235 no 3328 0.00479842265202214 4773 5846986
SGTC_2318 6029776 164 µM -2.59003966223127 0.00426759922426082 no 3329 0.00479824373161974 4755 818325
SGTC_917 harmaline 728.087 nM -2.59103732472549 0.00425531381694131 no 3330 0.0047843556380199 4720 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2553 4-methylesculetin 85.09 µM -2.61133141495261 0.00401217806317163 no 3331 0.00450952216811994 4766 5319502
SGTC_513 4245-1575 41.7 µM -2.66852336765151 0.00339250462509063 no 3332 0.00380927393598095 4656 719745
SGTC_1321 1326-2144 215 µM -2.67658494691591 0.00331244861663601 no 3333 0.00371883544219737 4769 3513030
SGTC_3018 9082602 49.47 µM -2.70004499998913 0.00308905099994267 no 3334 0.00346650488957448 4693 17332089
SGTC_847 0342-0274 5.54 µM -2.7290599309843 0.00283156969760839 no 3335 0.00317575798523993 4786 18097
SGTC_2736 butenafine 14.65 µM -2.73530041412877 0.00277878729127056 no 3336 0.00311616841310469 4752 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1411 3909-8223 150 µM -2.7984872517341 0.00229226097948562 no 3337 0.00256712980663339 4801 X1411
SGTC_193 1273-0060 1.558 µM -2.80109913017952 0.00227392173295894 no 3338 0.00254644359431061 4739 2847393 YHR072W ERG7
SGTC_2892 9047358 58.44 µM -2.84368799879511 0.00199305360224393 no 3339 0.00222973461891613 4790 6466771
SGTC_2797 7859098 81.82 µM -2.88162439156974 0.00176980342899041 no 3340 0.0019781551922403 4764 972681
SGTC_2800 7887935 81.82 µM -2.9540498384355 0.00140563722053977 no 3341 0.00156816675447368 4777 2961002
SGTC_2902 5787006 60.46 µM -2.9676234484286 0.00134553507914954 no 3342 0.00150055870722684 4779 591003
SGTC_986 1493-0483 84 µM -3.04350592403149 0.0010506928985874 no 3343 0.00116919418525646 4781 40079
SGTC_374 0880-0231 82.3 µM -3.0485721365671 0.00103329441551217 no 3344 0.00114965851153326 4738 6833587
SGTC_418 lividomycin a 100 µM -3.08166277669483 0.000926002133896591 yes 3345 0.00102923947084954 4795 72394 An antibiotic.
SGTC_3080 9117754 49.47 µM -3.08489124465372 0.000916102010490764 yes 3346 0.00101813298124629 4788 9550191
SGTC_358 0075-0058 9.45 µM -3.1357550516454 0.000772431829472157 yes 3347 0.000857061531726987 4766 1069125
SGTC_2586 curcumin 80 µM -3.28937677312634 0.000454939367035437 yes 3348 0.000502047565975433 4769 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_406 estrone 100 µM -3.3624227336083 0.000351060501166373 yes 3349 0.000386308724679388 4807 5870 A steroid.
SGTC_299 1273-0059 1.44 µM -3.63914444451253 0.000125842175890618 yes 3350 0.000136772670043905 4703 2848077
SGTC_310 1273-0058 1.06 µM -3.74389415186575 8.38017101716656e-05 yes 3351 9.05950038307057e-05 4597 2734232
SGTC_101 0490-5701 117.494 µM -4.0454810454722 2.45747125771555e-05 yes 3352 2.61078953308514e-05 4803 4661669
SGTC_431 k089-0097 107 µM -5.94813215167203 1.52969179089876e-09 yes 3353 1.35609794947752e-09 4784 5499420
SGTC_453 enantio-paf c16 10 µM -6.13951692460443 4.7870293660638e-10 yes 3354 4.13864027452856e-10 4721 13871343 A lipid and platelet activating factor
SGTC_2792 7535235 81.82 µM -6.21666588629149 2.96786588751562e-10 yes 3355 2.53914737810488e-10 4810 1281891
SGTC_2795 7780010 54.55 µM -6.96341521851203 2.17112234204778e-12 yes 3356 1.66060534292578e-12 4810 953673