SGTCid condition conc unit ATP17|YDR377W.score ATP17|YDR377W.strain.pval ATP17|YDR377W.strain.significant ATP17|YDR377W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_236 1509-0011 5.31 µM 15.9179691233797 8.94442691103935e-56 yes 1 2.37782033874205e-57 87 3107280
SGTC_310 1273-0058 1.06 µM 7.20341804287199 7.59846867843535e-13 yes 2 2.93607916587308e-13 114 2734232
SGTC_275 trichlorophene 5.69 µM 6.31779346849671 2.87741364439095e-10 yes 3 1.32662135079212e-10 107 62616
SGTC_63 0099-0242 26.702 µM 5.73545346786029 9.4815360898287e-09 yes 4 4.86258952767948e-09 32 3898502 YLR359W ADE13
SGTC_134 0269-0018 6.916 µM 5.60174752639012 2.02107448300639e-08 yes 5 1.06100743297624e-08 88 4378915
SGTC_59 0330-0160 1.33 µM 5.37091255070072 7.17313084861402e-08 yes 6 3.91695971885893e-08 49 4293482
SGTC_550 4123-0385 25.7 µM 5.10680840605604 2.87216255641772e-07 yes 7 1.63822829054938e-07 7 5731123
SGTC_127 0180-0333 59.125 µM 4.98745192556678 5.26130097872337e-07 yes 8 3.05904184804135e-07 16 771601
SGTC_744 1594-0068 283 µM 4.78984316228378 1.39151564918804e-06 yes 9 8.34558608124774e-07 12 668392
SGTC_2835 9006588 71.43 µM 4.73129161926771 1.84320526590746e-06 yes 10 1.11547877549167e-06 23 2345538
SGTC_70 0141-0289 43.283 µM 4.69194033616166 2.22247713759173e-06 yes 11 1.35313029155816e-06 124 352408
SGTC_2826 7992541 19.48 µM 4.55673996442818 4.180397020995e-06 yes 12 2.59768387910096e-06 9 2985066
SGTC_314 1671-0008 2.74 µM 4.25687166886243 1.59660686792515e-05 yes 13 1.03653635470969e-05 39 3913060
SGTC_1722 st034304 3.6505 µM 4.23911669588307 1.72389274872704e-05 yes 14 1.12200496413347e-05 16 4036148 YLR033W RSC58
SGTC_149 3970-0822 46.1 µM 4.18534613282471 2.17077837392792e-05 yes 15 1.42365944188007e-05 84 3114250 YBL034C STU1
SGTC_1807 st050092 58.9 µM 4.10552830108155 3.04124948621735e-05 yes 16 2.01695945042068e-05 10 5008496
SGTC_2823 7987624 58.44 µM 4.0025356614068 4.6579542215548e-05 yes 17 3.13336091958458e-05 29 2239440
SGTC_2250 alverine citrate 130 µM 3.98849067697817 4.93299513260495e-05 yes 18 3.32475078548739e-05 153 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1353 1498-1206 8.11 µM 3.95720824513957 5.60168425868317e-05 yes 19 3.79154096303639e-05 54 6756808
SGTC_2011 4012611 177 µM 3.93964031585604 6.01380940904704e-05 yes 20 4.08019314355015e-05 32 2049887
SGTC_2204 7233102 200 µM 3.85653886163889 8.38112301911601e-05 yes 21 5.7501910926452e-05 3 2172480
SGTC_489 paxilline 115 µM 3.78882757598738 0.000109320327846512 yes 22 7.567995830573e-05 18 105008 A toxic potassium channel blocker.
SGTC_601 0986-0029 62.9 µM 3.75503215869894 0.000124625661171532 yes 23 8.66596115560463e-05 43 24747981
SGTC_141 0443-0274 32.331 µM 3.7507787955988 0.000126688438736344 yes 24 8.81430858551818e-05 49 1627241
SGTC_2178 5812956 200 µM 3.73631037676968 0.000133947492468884 yes 25 9.33700753137293e-05 20 5403383
SGTC_995 3931-2021 34.6 µM 3.64919258847579 0.000186576576677401 yes 26 0.000131532917597205 30 730143
SGTC_2927 9011802 47.9 µM 3.63397813431846 0.000197551236950283 yes 27 0.00013954226219975 35 43912568
SGTC_800 3448-7362 155 µM 3.63303056956747 0.000198254316188318 yes 28 0.000140055908829308 189 15991913
SGTC_3207 9114163 49.47 µM 3.55731696058504 0.000262629063353873 yes 29 0.000187330994242309 43 849233
SGTC_2746 daunorubicin 9.88 µM 3.54901289178019 0.000270767759147815 yes 30 0.000193339074437902 7 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2187 6125751 200 µM 3.54869267750745 0.000271086252568151 yes 31 0.000193574319814656 30 874498
SGTC_533 1222-0222 6.71 µM 3.53741651653129 0.000282526916298692 yes 32 0.000202030950786217 44 3982874
SGTC_2453 5731132 22.18 µM 3.53209851926067 0.000288077115164006 yes 33 0.000206137864047541 29 1362040
SGTC_386 1509-0011 3.07 µM 3.53146444096528 0.000288745611360157 yes 34 0.000206632711316534 165 3107280
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.48574680784541 0.000340934597681976 yes 35 0.000245382635025446 34 75037 A free radical scavenger.
SGTC_811 0416-0114 265 µM 3.4520328103867 0.000384898973112327 yes 36 0.000278190033115748 41 6612453
SGTC_1025 k007-0731 70 µM 3.42120595886572 0.000429649724659782 yes 37 0.000311720498695685 31 6256118
SGTC_87 0100-0052 35.5 µM 3.37974851659593 0.000497459437114977 yes 38 0.000362760911340749 164 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2696 st077691 74.316 µM 3.36658382415457 0.000520983726545032 yes 39 0.000380527241676629 48 757133
SGTC_2870 9038528 12.99 µM 3.36053634079427 0.000532131539634303 yes 40 0.000388956480377544 35 6463316
SGTC_119 0121-0043 24.815 µM 3.33868214965534 0.00057428263735122 yes 41 0.000420884110403526 157 1092378
SGTC_913 3487-1245 167 µM 3.32117553778909 0.000610252016398097 yes 42 0.000448195700249306 60 4016153
SGTC_947 3447-0010 211 µM 3.32088289956799 0.000610870582248161 yes 43 0.000448665890006401 33 748350
SGTC_3211 9128781 49.47 µM 3.27836587957516 0.000707152145061775 yes 44 0.000522049837253455 100 17194361
SGTC_3292 9120825 59.784 µM 3.27490342208965 0.000715579147671339 yes 45 0.000528490509267526 32 24824900
SGTC_1279 0874-0590 65.2 µM 3.24681194256018 0.000787449062361354 yes 46 0.000583527380960393 59 3523074
SGTC_832 4083-0019 164 µM 3.23439831521678 0.000821278043705432 yes 47 0.000609496595992861 157 1990758
SGTC_2177 5811945 192 µM 3.22824261620393 0.00083854466323223 yes 48 0.000622766438737349 52 5343475
SGTC_10 0279-0212 42.575 µM 3.20894017496089 0.000894876224869494 yes 49 0.000666126047214081 178 39851 YBR002C RER2
SGTC_1237 0330-0133 46.1 µM 3.2086579383068 0.00089572510650349 yes 50 0.000666780217047321 44 X1237 YHR072W ERG7
SGTC_173 1273-0061 2.693 µM 3.18516041817787 0.00096905064701688 yes 51 0.000723368932364813 224 2847414 YPL266W DIM1
SGTC_214 4373-3496 70 µM 3.18374703571417 0.000973632233408036 yes 52 0.000726910007810077 114 3779166
SGTC_834 0312-0008 75.7 µM 3.16484311810929 0.00103685272930437 no 53 0.000775832949728019 75 6385573 YIL048W NEO1
SGTC_791 1348-1292 225 µM 3.12887664619652 0.00116764179362507 no 54 0.000877379785573879 88 5437054
SGTC_2678 equilin 100 µM 3.12257381111072 0.00119206009420282 no 55 0.000896385728306824 51 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1635 st007035 42.4 µM 3.11570070536326 0.00121921990284476 no 56 0.000917542105606738 285 3716403
SGTC_1360 1598-0022 39.8 µM 3.08924921877979 0.00132911257656003 no 57 0.0010033151764064 80 761525
SGTC_686 1319-0111 510 µM 3.06299515068896 0.00144706715492579 no 58 0.00109566805454623 61 4562600
SGTC_1575 cyproterone acetate 48 µM 3.05887690514163 0.00146641339617688 no 59 0.00111084208146952 57 9880 An androgen receptor antagonist and liver toxin.
SGTC_3138 9097216 49.47 µM 3.01913158347159 0.00166562580390805 no 60 0.00126750201863205 51 25237486
SGTC_2202 7226349 200 µM 2.98493656918813 0.00185641575099982 no 61 0.00141818566873672 33 844334
SGTC_2370 9071495 200 µM 2.96417671475 0.00198172794368642 no 62 0.0015174697356892 69 21791103
SGTC_163 TUB2.036 7.546 µM 2.93645183188513 0.00216105874820389 no 63 0.00165995187166927 200 15992207 YJR013W GPI14
SGTC_2715 st079500 56.4 µM 2.93111309515065 0.00219723524017096 no 64 0.00168874898258288 45 28246688
SGTC_2908 7930301 100 µM 2.91389494688127 0.00231768021054066 no 65 0.00178475001806357 90 2223178
SGTC_1564 D-Arginine 115 µM 2.90440886142883 0.00238656258411575 no 66 0.00183973655448365 83 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1999 st074831 12.5 µM 2.89682577008035 0.00244295324598854 no 67 0.00188479520780786 87 17112523
SGTC_2176 5809774 33.9695 µM 2.85492185683752 0.002776866787246 no 68 0.00215237095990381 52 2870539
SGTC_1354 1498-1681 81 µM 2.82497176371912 0.00304019536268958 no 69 0.00236423913763545 81 5754243
SGTC_2565 isoliquiritigenin 100 µM 2.81752448669121 0.00310907198179526 no 70 0.00241977121377871 93 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2174 5790901 200 µM 2.80403490875623 0.00323741721513917 no 71 0.00252337202833361 95 786020
SGTC_2299 7976368 114.88 µM 2.79671205774512 0.00330906790967679 no 72 0.00258127599811411 83 2979718
SGTC_2010 4012422 159 µM 2.78265004665827 0.00345066821676246 no 73 0.00269584638319176 92 952393
SGTC_580 1123-0028 41 µM 2.774193698174 0.00353841957561915 no 74 0.00276693592082109 117 1677248 YPR107C YTH1
SGTC_1226 3909-7979 35.4 µM 2.77286779387602 0.00355235870775741 no 75 0.00277823448385088 101 6615510
SGTC_1420 4'-methoxyflavone 42 µM 2.76331575125837 0.00365424413111843 no 76 0.00286086929725541 56 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1539 benzyladenosine 56 µM 2.76151113372449 0.00367378468014427 no 77 0.00287672774451783 61 92208 A nucleotide analog.
SGTC_958 1222-0007 33 µM 2.75100181028121 0.00378945441986991 no 78 0.00297066574961192 102 7312461
SGTC_1874 staurosporine 7.6 µM 2.74037908450341 0.00390967992994896 no 79 0.00306841789246232 102 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2398 5228213 48.84 µM 2.73929883436774 0.00392209537040336 no 80 0.00307851905905857 131 80771 YMR134W ERG29
SGTC_2005 4024620 188 µM 2.73500477434129 0.00397179747134684 no 81 0.00311896856429592 84 236743
SGTC_168 3970-0862 530.542 µM 2.71800013721571 0.00417420525438403 no 82 0.00328389054498622 276 3135186
SGTC_2429 5902844 64.44 µM 2.7104215730938 0.00426734959022932 no 83 0.00335988690550538 123 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1372 2752-0194 270 µM 2.70605278924617 0.00432188454034186 no 84 0.0034044110735242 69 823334
SGTC_358 0075-0058 9.45 µM 2.70496609648762 0.00433554596348699 no 85 0.0034155680534167 170 1069125
SGTC_2782 7736369 71.43 µM 2.68844014486019 0.00454811258148366 no 86 0.00358933521108558 132 2950836 YOL077C BRX1
SGTC_1570 verbenone 133 µM 2.66551018532906 0.0048584548033214 no 87 0.00384358015278024 86 29025 A natural terpanoid with antifungal properties.
SGTC_1047 2043-3044 82 µM 2.66238701103224 0.0049021539462124 no 88 0.00387943067178894 117 669592
SGTC_2407 paclitaxel 400 µM 2.65957670720482 0.00494177445953699 no 89 0.00391194559373235 119 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.65866424303843 0.00495469987246543 no 90 0.00392255509177601 87 688801
SGTC_650 1328-0195 38 µM 2.64909227720938 0.00509211656070941 no 91 0.00403541457188157 104 2780821
SGTC_1426 4048-4480 71.7 µM 2.64448100060348 0.00515951984384696 no 92 0.00409081498497766 90 14224343
SGTC_1843 st055809 45.5 µM 2.63529808160445 0.00529611652620917 no 93 0.00420317121527535 92 16413835
SGTC_2374 9071832 200 µM 2.63519300874417 0.00529769793110259 no 94 0.00420447263523477 60 17381698
SGTC_841 0251-0215 91.2 µM 2.6223789918288 0.00549373326243205 no 95 0.00436591349920891 155 3888614
SGTC_971 1315-0384 26.7 µM 2.61946123688563 0.00553926150660784 no 96 0.00440343905431095 108 6769120
SGTC_1482 3346-2049 8.48 µM 2.60628217449814 0.00574910859101033 no 97 0.00457655109656666 102 3826804
SGTC_2788 5282734 71.43 µM 2.59382026586975 0.00595399586333447 no 98 0.00474580458572577 159 743706
SGTC_1050 3232-1156 69.3 µM 2.58331737850858 0.00613167532488771 no 99 0.00489276288673894 98 700529
SGTC_3104 9120930 49.47 µM 2.57495342536619 0.00627651371880791 no 100 0.00501267926937676 84 17014836
SGTC_2287 7945887 168.79 µM 2.57003762322194 0.00636304677110718 no 101 0.00508437353266493 74 1245853
SGTC_2402 5553605 200 µM 2.55502522764017 0.00663388200290524 no 102 0.00530900510329894 123 6758546
SGTC_3205 9113483 49.47 µM 2.5529324148921 0.00667243625724106 no 103 0.00534101108513085 133 17018033
SGTC_2780 5215298 71.43 µM 2.53963058408748 0.00692214779360392 no 104 0.00554848053829083 147 2834131
SGTC_1183 1254-0324 198 µM 2.53596101338503 0.00699247203239958 no 105 0.00560696088362618 93 5799357
SGTC_1461 k072-0203 53.8 µM 2.52006698343887 0.00730440087595067 no 106 0.00586662518888944 97 5418714
SGTC_3143 9086658 49.47 µM 2.51177429814537 0.00747196895265642 no 107 0.00600629449350619 166 25236626
SGTC_1568 digitonin 820 nM 2.48778067785886 0.00797602576604804 no 108 0.00642714886959927 138 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_761 k216-0224 480 µM 2.47921218104331 0.00816314606679908 no 109 0.00658364755554374 123 1340404
SGTC_702 1488-0190 94 µM 2.47491073007282 0.00825852789169372 no 110 0.00666347412332586 91 949357
SGTC_2916 7875993 68.79 µM 2.44797278056752 0.00887841935760104 no 111 0.00718312541032994 135 1299250
SGTC_824 1304-0008 100 µM 2.43893409306131 0.00909536415123972 no 112 0.00736532728849807 153 768245
SGTC_2751 anetholtrithion 17.25 µM 2.43126464692191 0.00928307074051305 no 113 0.00752310998665932 143 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1224 0823-0416 294 µM 2.42894770335014 0.0093404397200774 no 114 0.00757135819638343 113 3598164
SGTC_2165 5727197 32.143 µM 2.40000441056187 0.010083657838505 no 115 0.00819743715265742 165 1361712
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.39924832157353 0.0101037457165847 no 116 0.00821438460147863 200 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2004 4023728 41.89 µM 2.39523703067365 0.0102109033124651 no 117 0.00830481195580615 152 360084 YDR527W RBA50
SGTC_1641 st009299 47.1 µM 2.38540884836972 0.0104776525864044 no 118 0.00853007478337477 67 4046054
SGTC_2401 5128683 200 µM 2.38090427838037 0.0106019283714011 no 119 0.00863509948057475 153 708373
SGTC_2460 5552655 174.22 µM 2.36519760387485 0.0110453554512474 no 120 0.00901022651099384 151 5401989
SGTC_873 0591-4978 488 µM 2.36123747803168 0.0111596713125352 no 121 0.00910703134896517 131 3305145
SGTC_1627 st003713 25.6 µM 2.33696307716504 0.0118831225313176 no 122 0.00972055201417588 259 16195070 YER133W GLC7
SGTC_3332 9141069 11.198 µM 2.33644230289116 0.0118990789143222 no 123 0.00973410068541225 116 17332883
SGTC_2191 5911152 200 µM 2.33570580257413 0.0119216768128696 no 124 0.00975328993574924 127 2875902
SGTC_1048 3161-0300 24.5 µM 2.33106159922782 0.0120650332750398 no 125 0.00987505589580436 143 2165101
SGTC_3213 9129884 49.47 µM 2.32849579624631 0.0121448731756528 no 126 0.00994289610349829 113 17190742
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.31403989615803 0.0126033082193191 no 127 0.0103327668986225 182 65057 A dermal irritant. YDR527W RBA50
SGTC_140 0062-0056 502.533 µM 2.29733793940417 0.0131515527804366 no 128 0.0107997495476985 160 3758964
SGTC_596 1155-0152 116 µM 2.2966449630303 0.0131747383794474 no 129 0.0108195157316218 203 280313
SGTC_258 haloperidol 50.781 µM 2.28202452654892 0.0136722075367599 no 130 0.0112439461339949 195 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3224 9130643 49.47 µM 2.28058531592587 0.0137220426379343 no 131 0.0112864985154415 175 17644395
SGTC_2294 7971431 200 µM 2.2705469411505 0.0140740162160469 no 132 0.0115872092873662 132 5741572
SGTC_539 4859-0462 2.54 µM 2.27050076318249 0.0140756531574735 no 133 0.0115886085214263 156 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2100 5377183 190 µM 2.26446436784735 0.0142910519979275 no 134 0.0117727844576847 151 2844202
SGTC_424 splitomicin 100 mM 2.25737888488015 0.01454750224357 no 135 0.0119922049806943 158 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_46 0329-0187a 2.197 µM 2.2423069343205 0.0151062128382096 no 136 0.0124707709503932 245 46494817
SGTC_52 0329-0193 875 nM 2.23864005362164 0.0152448984182375 no 137 0.012589672949164 166 3739292
SGTC_2589 lobaric acid 100 µM 2.20994990441268 0.0163682298031577 no 138 0.0135543196065684 184 73157 A novel microtubule depolymerizer.
SGTC_2382 9035899 200 µM 2.18820291368396 0.0172662647987204 no 139 0.0143274124859856 167 6462679
SGTC_2580 diallyl disulphide 81.36 µM 2.18715544698274 0.017310561897829 no 140 0.0143655890341362 172 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1663 st014140 55.4 µM 2.18324485038073 0.0174767987499126 no 141 0.0145088917450423 186 4207120
SGTC_1415 3966-0071 78.1 µM 2.17225849378909 0.017951132535174 no 142 0.0149180854246569 131 2893185
SGTC_3341 9147222 25.867 µM 2.16499661084808 0.0182706534230909 no 143 0.0151939724091323 154 1939759
SGTC_1261 0712-0010 12.7 µM 2.16202823574415 0.0184026495188892 no 144 0.0153079999258847 200 2840123
SGTC_1990 st072050 59.8 µM 2.16076305500399 0.0184591552766568 no 145 0.0153568236533045 146 17233948
SGTC_2379 9035213 200 µM 2.15499485267575 0.0187186520335886 no 146 0.0155811185080723 172 646551
SGTC_1475 4092-1048 11.7 µM 2.1468470413614 0.0190904870194467 no 147 0.0159027304461734 227 2881759
SGTC_3307 9126885 69.2785 µM 2.1408550162571 0.0193679314045359 no 148 0.0161428658494464 210 24824909
SGTC_2790 5423970 71.43 µM 2.13226457993152 0.0197716598561538 no 149 0.0164925510598619 245 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1515 3460-0031 42.1 µM 2.13113695838178 0.0198251818523767 no 150 0.0165389303691917 143 2876596
SGTC_2083 5306046 65.942 µM 2.1271812255209 0.0200139120707583 no 151 0.0167025142209969 221 539837
SGTC_108 0509-0257 621.132 µM 2.12438342922634 0.0201483148168082 no 152 0.0168190472462559 248 536624
SGTC_1044 1222-0021 1.78 µM 2.10852173635707 0.0209248446072128 no 153 0.0174929423056921 216 4306703
SGTC_2928 9011484 9.79 µM 2.1080541887013 0.0209481131128672 no 154 0.0175131512180453 178 2994751
SGTC_2629 bisabolol 100 µM 2.10519495765829 0.021090885798732 no 155 0.0176371705049754 221 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2067 5224629 34.075 µM 2.09970198623757 0.0213674823246697 no 156 0.0178775323819954 201 2835000
SGTC_2669 eugenol 100 µM 2.09757864702444 0.0214752211581618 no 157 0.017971191496191 115 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_844 0330-0132 15.3 µM 2.07591781655024 0.0226007724249837 no 158 0.0189507763012479 186 2828079
SGTC_218 alverine citrate 93.75 µM 2.07433743012505 0.022684804874092 no 159 0.0190239919481276 160 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1659 st012954 42.1 µM 2.07086940069666 0.0228701305911228 no 160 0.0191855012088818 154 24207262
SGTC_583 1488-1091 88.9 µM 2.06110552701614 0.0233987592631583 no 161 0.0196464868258442 248 4303273
SGTC_1631 benzylvanillin 81.9 µM 2.04597969501963 0.0242379722057896 no 162 0.0203791842281906 234 75506
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.03534137012676 0.0248432313388572 no 163 0.0209082681169474 166 61125 An anti-inflammatory.
SGTC_2980 9014342 25.29 µM 2.02514757452553 0.0254350417177514 no 164 0.0214261065118993 217 2996599
SGTC_1746 st038117 42 µM 2.02241992829638 0.0255953854853956 no 165 0.0215664940067187 235 2898218
SGTC_2368 9071271 200 µM 2.01514279926177 0.0260273146094268 no 166 0.0219448444465153 235 27209959
SGTC_1434 4073-0095 163 µM 2.00466715859676 0.0266597811827913 no 167 0.0224993208535762 192 24133745
SGTC_2041 5107442 45.335 µM 2.00405884711851 0.0266968989671933 no 168 0.0225318785255905 251 793005
SGTC_2705 st078069 42.8 µM 2.00155773173124 0.0268499651980925 no 169 0.0226661594150279 189 1530061
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.99479159156495 0.0272677235865899 no 170 0.0230328074120486 204 7104
SGTC_1838 st055369 84.5 µM 1.98529018738646 0.0278635047507605 no 171 0.0235560975701663 203 676036
SGTC_3334 9142812 21.919 µM 1.98164311366717 0.0280950548528874 no 172 0.0237595990995685 230 45283678
SGTC_2459 5811157 9.22 µM 1.97912871333332 0.0282556236273464 no 173 0.0239007582064184 201 2870684 YBR192W RIM2
SGTC_1742 st038235 28.8875 µM 1.97376988630428 0.0286003861576378 no 174 0.0242039572257097 314 564103 YBR002C RER2
SGTC_1094 duloxetine 25.4 µM 1.97365335767234 0.0286079217758874 no 175 0.0242105860648414 227 60834 A selective serotonin reuptake inhibitor.
SGTC_1813 st051246 8.6015 µM 1.97254708572797 0.0286795439340166 no 176 0.0242735933529984 178 5291959
SGTC_2219 9098279 200 µM 1.97013187611859 0.0288364274448374 no 177 0.0244116292605357 187 902349
SGTC_2688 kanamycin b 96.69 µM 1.96094348155103 0.0294398070475114 no 178 0.0249428081533836 807 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3127 9126946 49.47 µM 1.95945037411076 0.0295388389453165 no 179 0.0250300331100705 201 27243249
SGTC_1693 xanthone 101.9 µM 1.95360949749777 0.0299289014312966 no 180 0.0253737082881271 236 7020 An insecticide.
SGTC_131 0141-0277 33.849 µM 1.94640384619753 0.0304159818067496 no 181 0.0258031239761576 264 1547771
SGTC_3139 9095020 49.47 µM 1.94551614668348 0.0304764394908876 no 182 0.0258564441473024 143 25236292
SGTC_3160 9100216 49.47 µM 1.94138761520315 0.0307589269377854 no 183 0.0261056396852385 184 17191039
SGTC_797 k781-0471 270 µM 1.92730829319748 0.0317386270514875 no 184 0.0269706103415547 244 23738129
SGTC_1027 k015-0025 8.67 µM 1.92282464014105 0.0320559794075642 no 185 0.027251038252596 248 3598955
SGTC_3108 9121785 49.47 µM 1.92069861045461 0.0322073726974034 no 186 0.0273848574511162 233 17140271
SGTC_588 3970-1144 52.9 µM 1.91266062428258 0.0327850956757392 no 187 0.0278957565646626 266 1888707
SGTC_657 3534-0529 86.7 µM 1.91173353167469 0.0328522757603498 no 188 0.0279551905490573 237 1049549
SGTC_1220 1838-0075 193 µM 1.90969161780495 0.0330006395890996 no 189 0.0280864654328296 246 5529645
SGTC_1705 st027868 56.3335 µM 1.90902419705467 0.0330492534142501 no 190 0.028129485142006 204 292948
SGTC_1682 st012968 530 nM 1.90901870353824 0.0330496537976302 no 191 0.0281298394632119 205 24207270
SGTC_1702 st027038 51 µM 1.90601666357416 0.0332690497925254 no 192 0.0283240218636281 255 5521182
SGTC_1728 st035614 33.7865 µM 1.90141083016838 0.0336079855392249 no 193 0.0286241110390892 334 15945546
SGTC_15 0266-0086 27.098 µM 1.90079303405723 0.0336536635579976 no 194 0.0286645634286429 339 1712902 YIL048W NEO1
SGTC_903 1134-0042 114 µM 1.89810672829734 0.0338528755207027 no 195 0.0288410120136117 258 701009
SGTC_786 4544-0069 423 µM 1.88967794857106 0.034484245528505 no 196 0.0294005225258773 286 748821 YLR208W SEC13
SGTC_3201 9113999 49.47 µM 1.88856904283673 0.0345680252526034 no 197 0.0294747991873666 271 16649224
SGTC_3183 9108214 49.47 µM 1.88809099016726 0.034604194489718 no 198 0.0295068681055197 107 4974831
SGTC_578 3460-0051 92 µM 1.8733451864109 0.0357352102447241 no 199 0.0305103669520375 280 2876744
SGTC_1878 temozolomide 1 mM 1.87162634817058 0.0358689960028059 no 200 0.0306291577803126 207 5394 DNA alkylating agent.
SGTC_755 1995-0008 37.3 µM 1.87139477520272 0.0358870518091066 no 201 0.0306451912854036 232 689533
SGTC_636 0kpi-0074 126 µM 1.86648586194761 0.0362715562233699 no 202 0.0309867101356858 231 616434
SGTC_2318 6029776 164 µM 1.86309582349784 0.0365390541543929 no 203 0.031224392873973 284 818325
SGTC_946 3434-1334 87.4 µM 1.86052897073278 0.036742668898087 no 204 0.031405361786998 253 4047976
SGTC_1148 3909-7663 27.7 µM 1.86023065913935 0.0367663924399319 no 205 0.0314264495623161 253 4084526
SGTC_2497 7-hydroxyflavone 100 µM 1.85852543576331 0.0369022426883112 no 206 0.0315472173747118 254 5281894
SGTC_3354 9151612 71.43 µM 1.85645350417928 0.0370678595114302 no 207 0.0316944722488503 261 27261949
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.85613129283954 0.0370936695041946 no 208 0.0317174231776861 273 16486 A toxic proline analog.
SGTC_2919 7978188 46.38 µM 1.85417779767042 0.0372504643371697 no 209 0.0318568636938905 262 2980291
SGTC_1166 k206-0078 225 µM 1.85401023537109 0.0372639386927266 no 210 0.0318688478371036 296 5404595
SGTC_3155 9099265 49.47 µM 1.85279441909091 0.0373618266629857 no 211 0.0319559152334335 244 25236499
SGTC_1254 0550-0035 264 µM 1.85206552694496 0.0374206119690299 no 212 0.0320082069978893 289 15121435
SGTC_100 0086-0128 49.5915 µM 1.85098735932985 0.0375077049121239 no 213 0.0320856858269844 344 93297
SGTC_2603 homopterocarpin 100 µM 1.85039285734031 0.0375557987464279 no 214 0.0321284738670862 304 101795 A weak amylase inhibitor.
SGTC_1065 prochlorperazine maleate 2.48 µM 1.84951497192276 0.0376269097107902 no 215 0.0321917439682861 278 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_718 1130-0073 349 µM 1.84646098420642 0.0378751473661017 no 216 0.0324126497062348 284 6740020
SGTC_871 0574-0004 149 µM 1.84510920888954 0.0379854497532006 no 217 0.032510826944191 308 9551173
SGTC_237 nikkomycin 200 µM 1.84489511191643 0.0380029436906578 no 218 0.0325263989381717 275 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_599 1935-0052 86.5 µM 1.84431036464269 0.0380507570850495 no 219 0.0325689609286698 277 9557311
SGTC_795 0685-0265 78 µM 1.84337303821676 0.0381275024037939 no 220 0.0326372819186498 289 302754
SGTC_1872 amphotericin b 148 nM 1.84175017563111 0.0382606757380833 no 221 0.0327558505533884 260 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_908 3448-7491 47.7 µM 1.83798113738905 0.0385714295218842 no 222 0.0330325924252603 425 1203031
SGTC_1329 1447-1697 50.6 µM 1.83666964430529 0.0386800421027195 no 223 0.0331293395745625 279 2840515
SGTC_2794 7785382 27.27 µM 1.82904775634567 0.0393161979415443 no 224 0.0336962271768521 365 2205081
SGTC_2967 9089538 49.85 µM 1.82537998414599 0.0396253463495112 no 225 0.0339718538290514 302 728216
SGTC_3286 9117135 37.221 µM 1.82521442832152 0.0396393471810434 no 226 0.0339843386673233 269 3438150
SGTC_2702 st077768 96.8 µM 1.82415772291369 0.0397288061341782 no 227 0.0340641155027141 265 6484119
SGTC_247 mechlorethamine 29.705 µM 1.82414546754722 0.0397298446156076 no 228 0.0340650416341325 223 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2505 galangin 7.89 µM 1.81469499504759 0.0405372427999005 no 229 0.0347853973171415 208 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_204 PMA1.184 62.41 µM 1.81156282797035 0.0408077590625513 no 230 0.0350268864751873 310 2252213 YGL008C PMA1
SGTC_2747 doxorubicin 7.63 µM 1.80918996811497 0.0410136697524713 no 231 0.0352107478078211 144 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2764 methyldopa 94.69 µM 1.80833270495861 0.0410882677435929 no 232 0.0352773673318696 297 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2396 5342950 42.78 µM 1.80325699251944 0.0415322072134795 no 233 0.0356739317727059 349 1886677
SGTC_157 1348-1695 65.819 µM 1.80316675073272 0.0415401350972801 no 234 0.035681015268399 379 5380510
SGTC_1192 1488-0095 21.4 µM 1.80049810872936 0.0417751342975325 no 235 0.0358910109759045 260 915875
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.79759280849626 0.0420321963737173 no 236 0.0361207794084495 237 6857784
SGTC_3315 9136395 68.55 µM 1.79676046391975 0.0421060780377514 no 237 0.0361868276963811 288 16876844
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.79558790463771 0.0422103365743409 no 238 0.0362800404732923 288 2333 A French combination drug.
SGTC_81 0411-0046 9.971 µM 1.79351857803095 0.0423948410560278 no 239 0.0364450213746021 253 12925265
SGTC_1782 st039423 80.636 µM 1.79294851573363 0.0424457831742728 no 240 0.0364905783554311 284 2068169
SGTC_2630 antimycin a 100 µM 1.79282556753047 0.0424567766049954 no 241 0.0365004099648931 330 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2452 5863136 48.41 µM 1.79154259610101 0.0425716311221443 no 242 0.0366031327366061 291 2184096
SGTC_1969 st069479 40.1 µM 1.79032908054522 0.0426804988722484 no 243 0.0367005119582532 233 3895485
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.78335988562072 0.043310089398359 no 244 0.0372638693876242 325 6708561
SGTC_3180 9109287 49.47 µM 1.78059092427742 0.0435623073071496 no 245 0.0374896517534854 247 18891271
SGTC_3069 9117009 49.47 µM 1.77654277965724 0.0439331749164161 no 246 0.0378217486745129 178 41904981
SGTC_1488 4013-0813 75.9 µM 1.76294026369144 0.045198048126529 no 247 0.0389552826329977 238 2910057
SGTC_118 0083-0097 135.343 µM 1.76038253103959 0.0454391284397287 no 248 0.0391714846128855 563 5207356
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.75963272830282 0.0455099971384718 no 249 0.0392350493101628 274 756377
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.7592046265026 0.0455504996468207 no 250 0.0392713793687869 328 1273210
SGTC_3038 9091290 49.47 µM 1.75909369199546 0.0455609998348605 no 251 0.0392807980830296 291 25236843
SGTC_1832 st054113 55 µM 1.74254621493815 0.0471491785943245 no 252 0.0407064560269006 257 1251267
SGTC_3346 9158254 43.5805 µM 1.735603716909 0.0478285801073502 no 253 0.0413169641499415 325 17639500
SGTC_2479 5617353 43.85 µM 1.73454642583539 0.0479327322861657 no 254 0.0414105879039903 332 2731746
SGTC_432 NS 1619 61.3 µM 1.73324420632258 0.0480612614255054 no 255 0.041526136424205 292 4552 A K+/calcium channel activator.
SGTC_3015 9080845 49.47 µM 1.72949087263204 0.0484332593109154 no 256 0.0418606393308938 307 5296973
SGTC_2159 5658611 73.75 µM 1.72772037908588 0.04860953277607 no 257 0.0420191840428541 257 793844
SGTC_975 1335-0046 28.5 µM 1.72449654715698 0.0489318201250629 no 258 0.042309120875789 346 16486740
SGTC_929 2805-0021 398 µM 1.71653479030301 0.0497350761832181 no 259 0.0430321030204374 302 3098024
SGTC_3125 9127534 49.47 µM 1.71087113859475 0.0503128553224427 no 260 0.0435524517764911 221 1639235
SGTC_2977 9011197 71.43 µM 1.7104824725571 0.0503527005369653 no 261 0.0435883459280212 258 2704722
SGTC_520 3584-0023 682 µM 1.70746766895605 0.050662626446111 no 262 0.0438675810796846 326 1340790
SGTC_2472 5377652 49.4 µM 1.70732887668142 0.050676930981933 no 263 0.0438804708684013 380 1610903
SGTC_2855 9016525 58.44 µM 1.6941708476407 0.0520477260567885 no 264 0.045116411367765 335 43811474
SGTC_2796 7949634 45.45 µM 1.69080696455616 0.052402859879164 no 265 0.0454368382977674 341 2971588
SGTC_1144 3486-0183 12.5 µM 1.69041433224809 0.0524444361628894 no 266 0.0454743575002279 345 6744069
SGTC_905 2-aminofluorene 215 µM 1.68928843767229 0.052563803647224 no 267 0.0455820840306686 360 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2819 7996655 46.38 µM 1.68262007055526 0.0532752114581167 no 268 0.0462243318919023 293 6456960
SGTC_2920 7982904 15.77 µM 1.67938905931499 0.0536226425830861 no 269 0.0465381220675116 304 6456808
SGTC_3320 9137005 35.139 µM 1.67859692178988 0.0537080946182523 no 270 0.0466153134482824 295 4908713
SGTC_1980 st071811 45.7 µM 1.67442268765689 0.0541601742019727 no 271 0.0470237785163508 313 4974850
SGTC_1978 st071761 42 µM 1.6726234194475 0.0543559657185603 no 272 0.0472007267660389 310 5147680
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.67100218098735 0.0545328637005169 no 273 0.0473606235107938 325 4213774
SGTC_1821 st053465 65.6 µM 1.66398444016765 0.0553038459036317 no 274 0.0480577694527686 295 675086
SGTC_3289 9119912 71.43 µM 1.65743796861045 0.0560307900041755 no 275 0.0487154802018877 338 17014829
SGTC_1000 4048-0884 8.67 µM 1.65579587639972 0.0562143111050183 no 276 0.0488815815769024 357 13040088
SGTC_396 dithiazanine 1.25 µM 1.65389462488864 0.0564273876569716 no 277 0.0490744624894846 285 10578 An antihelmenthic.
SGTC_1393 3470-5649 58.2 µM 1.65200355391121 0.0566399541916899 no 278 0.0492669131825743 264 4108395
SGTC_2378 9074213 121.43 µM 1.63929844580372 0.058084476140123 no 279 0.0505755597841527 374 657714
SGTC_1171 0368-0077 21.4 µM 1.63928589814148 0.0580859169372284 no 280 0.0505768657676923 311 3239779
SGTC_462 ag-879 158 µM 1.63678513285076 0.0583736306440414 no 281 0.0508376866274718 390 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2183 6420625 130.508 µM 1.63587156484778 0.0584790155822597 no 282 0.0509332351404492 434 2897619
SGTC_1819 st053448 58.6 µM 1.62840859664336 0.0593455128948598 no 283 0.0517191380053091 335 2857616
SGTC_2376 9072922 81.32 µM 1.62721181195232 0.0594853988865078 no 284 0.0518460599577971 392 17087968
SGTC_2723 salbutamol 83.58 µM 1.61191932825588 0.0612956945575523 no 285 0.0534897478126637 239 9884233 β2-adrenoceptor agonist
SGTC_2808 7946468 45.46 µM 1.61169554254318 0.0613225019256728 no 286 0.053514104070698 409 2970879
SGTC_680 0417-1641 114 µM 1.60867509809737 0.0616852187863065 no 287 0.0538437018156916 331 2835990
SGTC_1319 1306-0155 43.7 µM 1.60423356670715 0.0622216300329155 no 288 0.0543312891924199 411 3122360
SGTC_419 nsc-638432 893 µM 1.60359861118551 0.0622986110434286 no 289 0.0544012785387223 369 368090
SGTC_66 0109-0187 42.4 µM 1.60268173998324 0.0624099021146696 no 290 0.0545024684759456 377 759417
SGTC_1014 4130-3005 69.3 µM 1.60069626184646 0.0626514334406366 no 291 0.0547221047624698 397 743608
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.5986772511537 0.0628977904621198 no 292 0.0549461674317938 363 6708760
SGTC_3095 9117207 49.47 µM 1.59368252911493 0.0635104827544068 no 293 0.055503579628636 287 17015229
SGTC_1404 3909-7820 48.3 µM 1.58814826500691 0.0641947731789786 no 294 0.0561264082557877 344 23741373
SGTC_308 4092-1169 104 µM 1.58561402054747 0.064510029535776 no 295 0.0564134468899188 414 2268590 YDL196W YDL196W
SGTC_1145 3546-0597 10.2 µM 1.58490801086107 0.0645980699858864 no 296 0.0564936180789866 408 875334
SGTC_1408 3909-7976 48.8 µM 1.58379216011514 0.0647374085054332 no 297 0.0566205119838122 416 24152374
SGTC_253 dyclonine 31.25 µM 1.57823880139134 0.0654343414272165 no 298 0.0572553796755661 428 3180 An oral anasthetic.
SGTC_3339 9145883 14.936 µM 1.57312967639212 0.0660806506622751 no 299 0.0578443972993102 360 2030670
SGTC_1621 st003705 32.4 µM 1.56998829187832 0.0664804872957815 no 300 0.0582089175693813 420 24207032
SGTC_40 0327-0103 19.753 µM 1.56885012874254 0.0666258144820612 no 301 0.0583414323477932 378 409036
SGTC_607 4491-0986 66.8 µM 1.56789499452979 0.0667479611335285 no 302 0.0584528200740005 410 698981 YDR232W HEM1
SGTC_3295 9122362 53.5725 µM 1.56646785759432 0.0669307923079289 no 303 0.0586195638489601 368 4730473
SGTC_3 0833-0587 95.581 µM 1.55901519306323 0.0678918568090098 no 304 0.059496392129055 360 5382644
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.55580599927381 0.0683089691559329 no 305 0.0598771155661395 288 4620898
SGTC_2727 riluzole 51.77 µM 1.55072629361345 0.0689732385450278 no 306 0.0604836452819518 345 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.55032056057856 0.0690265099402827 no 307 0.0605322974037505 459 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_860 0443-0016 25.1 µM 1.54997872642443 0.069071416233107 no 308 0.0605733110646959 385 5337942
SGTC_2140 5586273 200 µM 1.54934022141896 0.0691553560748095 no 309 0.0606499778649661 335 854421
SGTC_2077 5212015 200 µM 1.53788007868778 0.070675342461961 no 310 0.062038969514204 412 780900
SGTC_1390 3413-2614 145 µM 1.53365036416426 0.071242781289245 no 311 0.062557845472419 415 3421432
SGTC_2853 9015042 58.44 µM 1.53248949133518 0.0713991286746519 no 312 0.0627008444214724 368 6457456
SGTC_1093 fluphenazine 7.97 µM 1.52964194204488 0.0717837543136023 no 313 0.0630526908548932 450 6602611 An atypical antipsychotic.
SGTC_1430 4049-0248 69.1 µM 1.52925482829565 0.0718361652175597 no 314 0.063100641577403 446 22774488
SGTC_627 1391-0720 175 µM 1.52921035794818 0.0718421878877375 no 315 0.0631061518159899 393 997839
SGTC_945 3381-0768 11.3 µM 1.52909988125139 0.0718571515495061 no 316 0.0631198424012256 427 1126236 YIL048W NEO1
SGTC_34 0469-0683 81.75 µM 1.52900914554275 0.0718694431547358 no 317 0.0631310883571991 375 3690923
SGTC_2556 citropten 84.59 µM 1.52847959227791 0.0719412117954755 no 318 0.0631967533247103 463 2775 A potential DNA crosslinker.
SGTC_876 0720-0963 56.8 µM 1.52014139085644 0.0730785190034029 no 319 0.0642377218975175 438 765861
SGTC_1921 5740136 50 µM 1.5153004096775 0.0737450993856274 no 320 0.0648481723162907 468 1774243
SGTC_1730 st033808 45.1 µM 1.51361538341904 0.0739782067808541 no 321 0.0650617085830449 478 1045166
SGTC_1684 st024538 14.6195 µM 1.51305443937096 0.0740559328473018 no 322 0.0651329156003482 397 6732859
SGTC_175 3793-3120 23.7 µM 1.50560489164319 0.0750940887575724 no 323 0.0660843160002864 382 5322297
SGTC_227 fluconazole 33.516 µM 1.49923874047649 0.0759900274416871 no 324 0.0669058540770682 496 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_881 0833-0569 170 µM 1.4990545433046 0.0760160710093584 no 325 0.0669297414003554 440 5418700
SGTC_1029 k015-0030 64.7 µM 1.49596133887546 0.0764544338826625 no 326 0.0673318651233698 418 2208316
SGTC_1259 0671-0132 43 µM 1.49502951713037 0.0765868660602059 no 327 0.0674533694363222 426 X1259
SGTC_2851 9015922 71.43 µM 1.49205232402215 0.0770111594516179 no 328 0.0678427144620943 435 2996893
SGTC_284 0988-0104 32.6 µM 1.49038241492191 0.0772499266115875 no 329 0.0680618567993297 443 4666532
SGTC_109 0132-0036 33.701 µM 1.49037829741778 0.0772505160353772 no 330 0.0680623978143961 289 67274 A color developer.
SGTC_923 1900-2434 73.3 µM 1.48102356239144 0.0785984948657783 no 331 0.0693001473962666 426 5910570
SGTC_91 0417-1751 58.384 µM 1.47790894218291 0.0790512324784698 no 332 0.0697160762628517 537 6795624
SGTC_2307 7538926 6.34 µM 1.47705824042976 0.0791752322379867 no 333 0.0698300130985471 464 96582
SGTC_1427 4048-4900 550 nM 1.47665979440216 0.0792333610401373 no 334 0.0698834273315514 425 24132586
SGTC_1451 4152-0210 104 µM 1.47375881502822 0.0796575557586748 no 335 0.0702732704145999 449 659563
SGTC_2975 9084847 53.72 µM 1.47332766054531 0.079720747555626 no 336 0.0703313528379482 449 27211724
SGTC_836 0330-0104 1.35 µM 1.4715796728267 0.079977328475573 no 337 0.070567209025728 432 46494820
SGTC_753 1322-0200 289 µM 1.4684376016885 0.0804401112058896 no 338 0.0709926970094144 432 5403907
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.46637041341283 0.080745680415645 no 339 0.071273701051373 406 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2850 9015429 58.44 µM 1.46586336725084 0.080820765044029 no 340 0.0713427568020913 415 6457570
SGTC_1132 3456-3614 2.5 µM 1.46029204879247 0.0816492544308301 no 341 0.0721049131869239 555 3125502
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.45914672170278 0.0818203622990528 no 342 0.0722623645696972 400 688803
SGTC_2461 5755302 26.15 µM 1.45260613635251 0.0828026850454827 no 343 0.0731665706665425 489 2788904
SGTC_2365 9042475 200 µM 1.44453720349799 0.0840267427163884 no 344 0.0742939612479783 478 6464479
SGTC_3021 9087658 49.47 µM 1.44408239957728 0.0840961388324119 no 345 0.0743578991580496 380 25237042
SGTC_143 4032-1194 15.74 µM 1.44398688451936 0.0841107184334909 no 346 0.074371332332506 548 1806963
SGTC_2983 9022671 12.99 µM 1.44303733424357 0.0842557628171299 no 347 0.0745049772456921 424 6405161
SGTC_1696 st025591 34.7925 µM 1.4396044260253 0.0847817079357178 no 348 0.0749896733541452 477 2787147
SGTC_1289 0976-0073 69.1 µM 1.43768782351658 0.0850764134718933 no 349 0.0752613247646136 466 3391136
SGTC_2496 diffractaic acid 79.83 µM 1.4366171483633 0.0852413792530164 no 350 0.0754134041408477 493 94870 An apoptosis inducer which activates caspases.
SGTC_222 nsc-310342 10.666 µM 1.43581701076551 0.0853648179711743 no 351 0.0755272090268141 307 432556
SGTC_3216 9129716 49.47 µM 1.43511101332041 0.0854738446657398 no 352 0.0756277328395958 431 8056934
SGTC_1204 4049-0315 18.3 µM 1.43365252696966 0.0856994079031284 no 353 0.0758357229349552 464 588402
SGTC_19 0279-0214 38.434 µM 1.43206355880584 0.0859456577959467 no 354 0.0760628161615525 556 3566274 YBR002C RER2
SGTC_540 1187-0821 17.3 µM 1.43110238335489 0.0860948724934653 no 355 0.076200437166927 449 847520
SGTC_2576 guaiol 23.12 µM 1.43108856418918 0.0860970192192986 no 356 0.0762024171747335 489 227829
SGTC_2655 perillic acid 100 µM 1.42856543269142 0.0864896442880299 no 357 0.0765645877082575 401 5702197 An apoptosis inducer.
SGTC_910 3454-3003 490 µM 1.42757261122053 0.0866445039142369 no 358 0.0767074558049744 490 820824
SGTC_2457 5731572 11.68 µM 1.42586264517266 0.0869117089723947 no 359 0.0769539969242147 441 2865357
SGTC_182 3448-4371 550.524 µM 1.42472675391022 0.0870895471585731 no 360 0.0771181011759208 482 3491403
SGTC_3300 9124615 50.48 µM 1.42429153993415 0.0871577573914705 no 361 0.0771810477369779 451 24824903
SGTC_1231 0242-0792 125 µM 1.41968687811676 0.0878818825487185 no 362 0.0778494299748688 470 3707635
SGTC_1187 1391-0724 117 µM 1.41712305035909 0.0882870076510979 no 363 0.0782234772005168 503 6997986
SGTC_2557 derrustone 83.84 µM 1.41251871259697 0.0890180571381368 no 364 0.0788986424116873 518 629853 An antioxidant.
SGTC_1847 st056231 15 µM 1.41168575531625 0.0891507890802938 no 365 0.0790212547298864 543 5393180
SGTC_884 0851-0618 334 µM 1.4091084797087 0.0895624113878969 no 366 0.0794015469205148 502 9642473
SGTC_620 0109-0052 432 µM 1.40625256040195 0.0900201853861552 no 367 0.079824570806806 468 493037
SGTC_1882 5615643 20 µM 1.4061940409483 0.0900295835859471 no 368 0.0798332565999692 430 2253075
SGTC_1107 amlodipine 47 µM 1.40122529608904 0.0908302233385411 no 369 0.0805733560669994 490 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1141 3253-0389 52.6 µM 1.39936454142189 0.0911314122250493 no 370 0.0808518471650958 455 5402031
SGTC_1419 3993-2473 62.6 µM 1.39659752042668 0.0915806615434394 no 371 0.0812673181820794 487 704026
SGTC_2995 9067767 71.4286 µM 1.39511947429854 0.0918213062943699 no 372 0.0814899072644444 414 11673567
SGTC_484 loperamide 105 µM 1.39347210674164 0.0920900703205753 no 373 0.0817385370712664 360 3955 An opioid-receptor agonist.
SGTC_2146 5545642 200 µM 1.3907712061754 0.0925319752745593 no 374 0.082147408576334 470 825326
SGTC_3039 9090270 49.47 µM 1.39019022246847 0.0926272369880063 no 375 0.082235560866144 439 17173750
SGTC_3269 9137823 49.47 µM 1.38819017259296 0.0929557323562576 no 376 0.082539571997277 438 17682936
SGTC_1198 1612-1005 86.7 µM 1.38726522114356 0.0931079406143494 no 377 0.0826804520260566 493 6998509
SGTC_558 k064-0027 21.3 µM 1.38724387683795 0.0931114551658735 no 378 0.0826837051276017 490 5088526
SGTC_1501 4491-0275 38.4 µM 1.38358140250278 0.0937159706631209 no 379 0.0832433330481976 463 5104718
SGTC_3017 9080681 49.47 µM 1.38309670022954 0.0937961905809291 no 380 0.0833176086737227 470 16451914
SGTC_1529 apigenin 74 µM 1.38126527259656 0.0940997558572355 no 381 0.083598705875534 529 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_630 4356-0227 183 µM 1.37349650715302 0.0953955155800687 no 382 0.084799023164404 480 779312
SGTC_2724 maprotiline 69.64 µM 1.37248340945408 0.0955654545290147 no 383 0.0849565000574355 481 4011 A tricyclic antidepressant.
SGTC_1240 0356-0016 42.1 µM 1.36791041652527 0.0963353099958837 no 384 0.0856700594099846 502 4305613
SGTC_1335 1486-0900 202 µM 1.36785451263466 0.0963447494368447 no 385 0.0856788102021159 538 X1335
SGTC_1717 st033143 58.0435 µM 1.36628013167469 0.096610864799998 no 386 0.0859255273320915 553 674616
SGTC_311 1315-0136 58 µM 1.36226282349393 0.0972923505731145 no 387 0.0865574778295089 509 6759207
SGTC_2720 fluspirilene 36.88 µM 1.35748550264171 0.0981073459202745 no 388 0.0873134983973053 441 3396 An atypical antipsychotic.
SGTC_1849 st056239 19.2 µM 1.3546316007265 0.0985965926843765 no 389 0.0877674800495449 527 5393181
SGTC_375 3970-0961 9.27 µM 1.35441965648082 0.0986329975784153 no 390 0.0878012649806266 508 2898222
SGTC_1462 k081-0014 26.5 µM 1.35106280124886 0.0992109050064063 no 391 0.0883376580936863 359 3270634
SGTC_1383 3049-0032 20.7 µM 1.34661440705422 0.0999805382517146 no 392 0.0890522258385523 534 712864
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.34577453112533 0.10012633630539 no 393 0.0891876207656306 512 688669
SGTC_1687 st020778 55.3625 µM 1.34145229263283 0.100879109549035 no 394 0.0898868246011763 675 4259299
SGTC_2952 9073731 13.78 µM 1.34031665515499 0.101077578158588 no 395 0.0900712094882084 552 16457353
SGTC_1508 1080-0625 72.9 µM 1.33695792546408 0.10166622864864 no 396 0.090618185558801 467 767111
SGTC_41 0478-0632 82.643 µM 1.33618491361287 0.101802059234678 no 397 0.0907444204372773 609 3750424
SGTC_3152 9099253 49.47 µM 1.33483510172923 0.102039559491415 no 398 0.0909651611025696 635 25236131
SGTC_2523 spermine 47.74 µM 1.3316922380265 0.102594110011977 no 399 0.0914806704575234 504 1103 A DNA binding polyamine.
SGTC_1365 1672-3266 55.4 µM 1.32911420530017 0.103050630533055 no 400 0.0919051471896388 548 6415873
SGTC_2526 patulin 37.61 µM 1.32651457885302 0.10351246717729 no 401 0.0923346546844169 600 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_188 3229-0966 278.469 µM 1.32640563997253 0.103531853455083 no 402 0.0923526858242111 611 5722370
SGTC_2045 5106652 78.05 µM 1.32236748598215 0.104252325481553 no 403 0.0930229051618722 508 673349
SGTC_144 4161-2749 112.381 µM 1.31713029885831 0.105192127844726 no 404 0.0938974762399686 451 797501 YMR168C CEP3
SGTC_3056 9094900 49.47 µM 1.3113896271471 0.106229305419127 no 405 0.094863080754945 513 25236784
SGTC_2811 7967822 32.47 µM 1.30891666175481 0.106678369621011 no 406 0.0952812910029036 548 2232244
SGTC_1113 artemisinin 1.17947 µM 1.30847794516364 0.106758178765655 no 407 0.0953556251762136 555 2240 An anti-malaria and mitochondrial poison.
SGTC_2144 5628481 200 µM 1.30503115212291 0.107386701609282 no 408 0.0959411201603418 482 2818399
SGTC_1017 4239-0030 168 µM 1.30466074624144 0.107454403527724 no 409 0.0960041967297986 583 1149593
SGTC_1846 st056244 14.8 µM 1.30204752146779 0.10793291686569 no 410 0.0964500705285829 575 5393182
SGTC_1750 st081859 2.357 µM 1.30042334754801 0.108231095118814 no 411 0.0967279560744567 740 5291695
SGTC_778 3456-2434 196 µM 1.30021154440637 0.108270023215567 no 412 0.0967642375031476 641 5539063
SGTC_361 000s-0510 1.45 µM 1.29788015190006 0.108699184686573 no 413 0.0971642607149513 568 660
SGTC_2874 9043904 71.43 µM 1.29383853369157 0.109446059726273 no 414 0.097860599741162 442 4463428
SGTC_1346 1488-2224 62.4 µM 1.29276240387699 0.10964554414063 no 415 0.0980466235791879 570 3722427
SGTC_2518 prenyletin 46.28 µM 1.2891781083154 0.110311854852897 no 416 0.0986680869423898 455 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2380 9035439 200 µM 1.28835909001303 0.11046451481574 no 417 0.0988104962935373 608 6462575
SGTC_789 1309-1135 70.6 µM 1.28799414306606 0.110532587436185 no 418 0.0988740009964645 570 3092424
SGTC_667 1498-1044 59 µM 1.2850127174799 0.111089831615978 no 419 0.0993939199917266 562 6739982
SGTC_1914 st062367 72.6 µM 1.28416370779929 0.11124888340178 no 420 0.099542340369362 532 978205
SGTC_2873 9040596 71.43 µM 1.27797751142424 0.112412716314366 no 421 0.100628677877877 575 6463863
SGTC_2190 6049624 200 µM 1.27597970554423 0.112790422933686 no 422 0.100981346611882 487 2265554
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.27556539878328 0.112868865375234 no 423 0.101054596032395 538 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_503 tyrphostin 8 294 µM 1.27460674977023 0.11305051971762 no 424 0.101224233608764 557 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1342 1486-1464 234 µM 1.27301912054045 0.113351818195206 no 425 0.101505628493705 599 3253938
SGTC_2739 tacrine 100.86 µM 1.27250168976791 0.113450139264648 no 426 0.101597462043091 527 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1753 st043925 64 µM 1.27138034292154 0.1136634238367 no 427 0.101796686140319 577 670181
SGTC_965 1291-5240 308 µM 1.27132671723056 0.113673630810496 no 428 0.101806220669217 582 2834598
SGTC_656 4090-1979 187 µM 1.26869916984574 0.114174551886584 no 429 0.102274189335603 608 22330961
SGTC_1824 st053723 68.6 µM 1.26563732530869 0.114760249276706 no 430 0.102821478239014 564 675225
SGTC_780 0109-0199 192 µM 1.265046681963 0.114873478411671 no 431 0.102927297086028 614 610414
SGTC_705 1124-0212 310 µM 1.26379907425434 0.115112911899969 no 432 0.103151076780661 601 9554485
SGTC_3175 9106517 49.47 µM 1.26205880230632 0.11544748697184 no 433 0.103463814056035 537 41468073
SGTC_56 0957-0365 83.25 µM 1.26174465083063 0.115507957555676 no 434 0.103520342207028 585 6752360
SGTC_2137 5261020 140 µM 1.25961995044757 0.115917529068764 no 435 0.103903247515131 556 763655
SGTC_2119 5528445 120.635 µM 1.25244201031542 0.117308819690747 no 436 0.105204423223999 560 791935
SGTC_2256 7954252 200 µM 1.25065231089145 0.117657549272162 no 437 0.105530678248714 483 2972920
SGTC_1146 3579-1023 7 µM 1.25027551796927 0.11773106218184 no 438 0.105599459226977 643 X1146
SGTC_3086 9117350 49.47 µM 1.24849455558213 0.118078970756006 no 439 0.105925000489429 478 2679265
SGTC_987 1497-1013 404 µM 1.24799997849099 0.118175714592266 no 440 0.106015532535541 546 1676435
SGTC_1852 st056254 31.4 µM 1.2452703104473 0.118710671217295 no 441 0.106516202601005 565 442583
SGTC_248 streptozotocin 5.23457 mM 1.24407449415928 0.118945563770008 no 442 0.106736073625551 609 5300 DNA alkylating agent.
SGTC_1409 3909-8004 61.9 µM 1.24182305795089 0.119388700598474 no 443 0.10715092667439 607 2119279
SGTC_2170 morpholine 200 µM 1.24025172784084 0.119698665606183 no 444 0.107441150477616 585 121171 Reacts with secondary amines.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.23821956613212 0.120100376561213 no 445 0.107817329235827 622 23665772 A membrane-active detergent.
SGTC_1876 myriocin 605 nM 1.23787032988002 0.120169507974735 no 446 0.107882072680582 584 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2022 5136654 200 µM 1.23780141104113 0.120183153790119 no 447 0.107894852562509 576 1713771
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.23742250796928 0.120258195469952 no 448 0.107965133472696 590 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2097 5376186 200 µM 1.23566497453632 0.120606706290445 no 449 0.108291561004491 600 742755
SGTC_3162 9099653 49.47 µM 1.23398268466145 0.120940962184638 no 450 0.108604678263151 528 25237511
SGTC_1361 1608-0041 5.61 µM 1.23175370447726 0.121384843785734 no 451 0.109020550888867 606 X1361
SGTC_2312 7706453 155.7 µM 1.23112433971444 0.121510383299636 no 452 0.109138181751743 591 976098
SGTC_1276 0871-0068 94.2 µM 1.22962272586369 0.121810279083342 no 453 0.109419207897162 562 3414906
SGTC_679 0422-0091 41.4 µM 1.22917215535422 0.121900366405091 no 454 0.109503633188425 626 627384 YHR062C RPP1
SGTC_3018 9082602 49.47 µM 1.22689971259731 0.122355433117982 no 455 0.109930143304219 638 17332089
SGTC_1496 4469-0713 57.4 µM 1.22585524779602 0.122564991277116 no 456 0.110126576127983 602 746691
SGTC_888 0916-0002 6.97 µM 1.22497207403644 0.12274238488773 no 457 0.110292871262313 615 2802138 YIL048W NEO1
SGTC_2329 6138490 200 µM 1.22419084345919 0.12289945230114 no 458 0.110440121280282 533 720019
SGTC_2414 st077232 92.9 µM 1.22140231428478 0.123461238770075 no 459 0.110966865694702 586 729801
SGTC_124 0136-0217 7.121 µM 1.21318229210885 0.125127729824367 no 460 0.112530066401391 702 3976905
SGTC_399 oxolinic acid 75 µM 1.21317910766252 0.125128378454427 no 461 0.112530675019796 584 4628 A DNA gyrase inhibitor.
SGTC_3242 9133940 49.47 µM 1.21081077251933 0.125611427750577 no 462 0.112983967797466 609 17248444
SGTC_1442 4112-3290 3 µM 1.208977711363 0.125986193920848 no 463 0.113335704223256 639 704353
SGTC_553 k007-0256 45.7 µM 1.20881122061179 0.12602027124727 no 464 0.113367689903554 621 6287000
SGTC_2142 5622915 118.518 µM 1.20856846931642 0.126069969097189 no 465 0.113414338056873 567 5322196
SGTC_901 1112-0062 60.1 µM 1.20804079943404 0.126178044725538 no 466 0.113515784630614 597 1908457
SGTC_2797 7859098 81.82 µM 1.20775649633846 0.126236301524065 no 467 0.113570469814072 613 972681
SGTC_2311 7694451 200 µM 1.20728666643014 0.126332615868442 no 468 0.113660881905958 615 2163142
SGTC_3055 9094636 49.47 µM 1.20701529049765 0.126388270805059 no 469 0.113713127720865 581 25236176
SGTC_856 0433-0016 11.3 µM 1.20606785413468 0.12658270903071 no 470 0.113895664187929 634 3911780
SGTC_1861 st057647 17.4 µM 1.20396081541453 0.127015874023064 no 471 0.114302362054607 647 688668
SGTC_519 k048-0011 62.8 µM 1.20223361251563 0.127371720984346 no 472 0.114636514939307 607 6836379
SGTC_2330 7979373 200 µM 1.20176373785015 0.127468646767845 no 473 0.114727539289319 616 1863007
SGTC_1714 st033236 13.627 µM 1.20161744819497 0.127498833877122 no 474 0.114755889087814 629 2916566
SGTC_17 0960-0276 49.807 µM 1.20032504590575 0.127765739158924 no 475 0.115006563149111 663 6821114
SGTC_767 0929-0023 86 µM 1.19783762414688 0.128280530718594 no 476 0.11549011839484 716 1204563
SGTC_3270 9137563 49.47 µM 1.19658440711871 0.12854043875705 no 477 0.115734290550848 558 17015724
SGTC_859 0439-0102 54.6 µM 1.19451889873021 0.128969607230762 no 478 0.116137526282817 686 610143
SGTC_1896 st058441 89 µM 1.19079350689724 0.12974617420705 no 479 0.116867329270154 568 688759
SGTC_1791 st048313 56.1 µM 1.18879195589833 0.130164736986848 no 480 0.117260772120366 580 1204976
SGTC_291 SEC14.278 35.5 µM 1.18734472698764 0.130467961818257 no 481 0.117545836264365 654 1068044
SGTC_1127 asiatic acid 681.4 nM 1.18648467849783 0.1306483912771 no 482 0.11771547430506 610 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_961 1252-1571 372 µM 1.18486934117242 0.130987738798197 no 483 0.118034555502926 643 6813498
SGTC_1089 terbinafine 2.25 µM 1.18371674868203 0.131230245610933 no 484 0.118262603359585 617 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3090 9117696 49.47 µM 1.1813819649139 0.131722436634025 no 485 0.118725509645709 611 7923821
SGTC_1831 st055328 12 µM 1.17318004633988 0.133461555934197 no 486 0.120361805995942 664 1103068
SGTC_2707 st078556 66.6 µM 1.17285533886661 0.133530729780249 no 487 0.120426910967193 626 17250899
SGTC_830 4076-0286 57.8 µM 1.16968252624226 0.134207945478363 no 488 0.121064376304868 793 6866659
SGTC_1030 k029-0042 36.7 µM 1.16944320883494 0.134259121693901 no 489 0.121112554838043 701 6080581
SGTC_895 0964-0006 13.7 µM 1.16927169347516 0.134295807198701 no 490 0.121147091998774 647 6738897
SGTC_2485 5633444 17.78 µM 1.16684711250179 0.134815138557666 no 491 0.121636058589512 635 5724239
SGTC_2356 9061756 188.97 µM 1.16458931949533 0.135299982339128 no 492 0.122092634572387 613 20104043
SGTC_2994 9053520 71.4286 µM 1.16454681938067 0.135309120360525 no 493 0.122101240565607 655 4647384
SGTC_1456 k015-0012 13 µM 1.1641639404305 0.135391462883103 no 494 0.122178790234951 736 2989616
SGTC_456 gingerol 170 µM 1.16397219935918 0.135432711909361 no 495 0.122217639148325 640 442793 A herb.
SGTC_3225 9130819 49.47 µM 1.16127299019686 0.136014303582282 no 496 0.122765449980645 656 4547121
SGTC_3031 9088762 49.47 µM 1.15818571048841 0.136681605187615 no 497 0.123394129205148 664 205253
SGTC_327 1273-0057 3.96 µM 1.15748115825513 0.136834204156649 no 498 0.123537916460519 623 3108138
SGTC_1772 st048439 82.2 µM 1.15697432833981 0.136944050440439 no 499 0.123641424462141 666 2927068 YDL195W SEC31
SGTC_84 0443-0269 128.823 µM 1.15129185398811 0.138179750401654 no 500 0.124806093641674 689 6150058
SGTC_2737 bleomycin 30.5 nM 1.15010365210023 0.138439092556953 no 501 0.125050591182575 718 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1225 1216-0074 20.6 µM 1.14984213454901 0.138496217034903 no 502 0.125104448810169 657 4241466
SGTC_579 4491-1009 110 µM 1.14916554741361 0.138644081590387 no 503 0.125243862148174 844 1271041
SGTC_1418 3966-3099 2.4 µM 1.14681307920812 0.139159037954604 no 504 0.125729441231298 682 740335
SGTC_2602 kawain 100 µM 1.14514284691262 0.139525441806055 no 505 0.126074994480035 729 5369129
SGTC_2766 oltipraz 83.91 µM 1.14435072794657 0.139699440485568 no 506 0.126239106699925 638 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3255 9139072 49.47 µM 1.14416037755706 0.139741275267745 no 507 0.126278565915104 657 17646060
SGTC_3234 9132280 49.47 µM 1.14301296367118 0.139993631719548 no 508 0.126516604347481 673 17612295
SGTC_205 1486-1330 71.903 µM 1.14258726947877 0.140087335473666 no 509 0.126604996805207 617 4118834
SGTC_2972 9093619 59.92 µM 1.13957023186941 0.140752666543724 no 510 0.127232696543651 654 25236256
SGTC_1340 1486-1359 257 µM 1.13737268148066 0.141238628083018 no 511 0.127691261272456 686 4309068
SGTC_2897 9048598 12.99 µM 1.13716916073545 0.141283691701166 no 512 0.127733788173228 632 6467404
SGTC_1075 aripiprazole 15.2 µM 1.13699894222119 0.141321389014454 no 513 0.127769363928948 721 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2670 beta-carotene 100 µM 1.13313168150356 0.142179686182178 no 514 0.128579479344535 590 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2957 9076800 11.52 µM 1.13305440413036 0.142196872942916 no 515 0.128595703687129 615 16459615
SGTC_1752 st044819 83.042 µM 1.13300762847007 0.142207276697999 no 516 0.128605524901848 652 441209 YML126C ERG13
SGTC_2754 granisetron 64.02 µM 1.13160603180907 0.142519256181985 no 517 0.128900051539372 680 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1673 st016611 27.3 µM 1.13152381423661 0.142537571240959 no 518 0.128917342968204 696 5226799
SGTC_161 4065-0411 162.148 µM 1.13100453509089 0.142653284358849 no 519 0.129026591319757 726 1906281 YLR208W SEC13
SGTC_1594 piperine 70.1 µM 1.13024656185894 0.1428223006557 no 520 0.129186172455191 691 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1405 3909-7894 12 µM 1.12820839797801 0.143277450758882 no 521 0.129615959046794 675 7104060
SGTC_614 0462-0418 107 µM 1.12306942344096 0.144429399429935 no 522 0.13070400549095 620 5188303
SGTC_2310 7668677 200 µM 1.12216651133704 0.144632438365803 no 523 0.130895824283218 657 2197143
SGTC_2246 7293507 91.5585 µM 1.12208941705485 0.144649783555291 no 524 0.130912211556263 705 887656
SGTC_2617 dihydrotanshinone i 20.83 µM 1.12190617852381 0.144691015413707 no 525 0.130951166694814 716 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2664 lyso-paf C-16 73.48 µM 1.12145265852058 0.144793099347135 no 526 0.131047616091794 718 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2767 sibutramine 71.45 µM 1.11690306995182 0.14581986101278 no 527 0.132017885935428 716 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1487 3970-0795 2.82 µM 1.113993245769 0.146479116612546 no 528 0.132641042127272 736 3765103
SGTC_85 0868-0259 160.055 µM 1.11254505629869 0.146807965838213 no 529 0.132951934505146 661 83173
SGTC_1904 st060225 78 µM 1.1124631860987 0.14682657138388 no 530 0.132969525090277 691 66595
SGTC_1033 k072-0102 21.3 µM 1.10958796946858 0.147480986698592 no 531 0.133588308885096 718 5965931
SGTC_964 1287-0107 19.4 µM 1.10945426770873 0.14751146543973 no 532 0.133617131333943 747 51516812 YPR165W RHO1
SGTC_2277 7947813 106.88 µM 1.10880777745643 0.147658899313541 no 533 0.133756557303835 663 1246798
SGTC_542 3381-0244 89.3 µM 1.10721115046595 0.148023437204311 no 534 0.134101323866105 770 1112843
SGTC_13 0199-0087 65 µM 1.10689971237745 0.148094614117983 no 535 0.134168645131728 716 4589825
SGTC_2667 digitoxin 100 µM 1.10628599360701 0.148234942114644 no 536 0.134301376114485 613 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_573 3702-0553 84.7 µM 1.10581901298346 0.148341777726139 no 537 0.134402431947302 687 1222756
SGTC_2844 9010103 25.97 µM 1.10034434491814 0.149598110654022 no 538 0.135591058863316 690 2480525
SGTC_2729 fluphenazine 10.66 µM 1.1002097493213 0.149629086962413 no 539 0.135620371871433 704 3372 An atypical antipsychotic.
SGTC_685 1278-0033 54.9 µM 1.09887643534371 0.14993617175115 no 540 0.135910983222407 727 3590572
SGTC_2974 9094440 9.66 µM 1.09621480062545 0.150550447378136 no 541 0.136492392010938 726 25236134
SGTC_1530 rhein 70.4 µM 1.09530145897519 0.150761622206413 no 542 0.13669229427173 757 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_281 1672-3440 14.9 µM 1.09156437861964 0.151627730598138 no 543 0.137512310178525 768 6833000
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.09075014067864 0.151816876896765 no 544 0.137691420515482 693 140250 A respiratory chain inhibitor.
SGTC_2504 purpurogallin 52.29 µM 1.08947054008572 0.152114442924715 no 545 0.137973219634721 682 5281571 An antioxidant.
SGTC_3024 9090631 49.47 µM 1.08890196775141 0.152246786359177 no 546 0.138098559210933 675 25236383
SGTC_2561 acetosyringone 100 µM 1.08649724760922 0.152807364889862 no 547 0.138629528988424 823 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_365 0121-0052 13.6 µM 1.08312666836576 0.153595401715406 no 548 0.139376101650543 788 3101739
SGTC_575 k072-0246 11.9 µM 1.08284621689119 0.15366109194226 no 549 0.139438343796854 746 6796779
SGTC_869 0564-0080 44.1 µM 1.08246931293555 0.153749403553658 no 550 0.139522021951308 723 6843321
SGTC_926 2268-1401 59.4 µM 1.08130965014492 0.154021332503073 no 551 0.139779698109405 722 2931578
SGTC_1971 st069429 63.5 µM 1.0789449765575 0.154576809446157 no 552 0.140306128584894 705 1246522 YGL099W LSG1
SGTC_1623 st003709 20.3 µM 1.07606106644547 0.155256048241944 no 553 0.140949973236009 782 16192618
SGTC_2909 7941780 10.49 µM 1.075691923964 0.155343133282664 no 554 0.141032530243068 753 1243215
SGTC_278 4092-0821 23.9 µM 1.07284450668774 0.15601595556923 no 555 0.141670443978416 736 877900
SGTC_3258 9138477 49.47 µM 1.07167586890248 0.156292650542109 no 556 0.141932821551119 731 4970355
SGTC_380 3970-0968 6 µM 1.07165766535757 0.156296963097747 no 557 0.141936911134031 695 2891601
SGTC_1374 2889-5571 141 µM 1.07120407154302 0.156404448168129 no 558 0.142038840647614 769 2853281
SGTC_1534 6-azauridine 81.6 µM 1.06947036985337 0.156815720283924 no 559 0.142428886658426 780 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1902 st060212 70.5 µM 1.06877642662502 0.156980538109882 no 560 0.14258521197569 742 688944
SGTC_271 rotenone 740 µM 1.06747139525096 0.157290803479351 no 561 0.142879511927982 758 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_159 3970-0959 50 µM 1.06381763737515 0.15816161108311 no 562 0.143705659896907 939 6615653
SGTC_1252 0493-0875 34.8 µM 1.06289131275595 0.158382885754877 no 563 0.143915621534427 706 3960963
SGTC_2458 5808907 16.39 µM 1.06151621937382 0.158711733846198 no 564 0.14422768293921 811 2731747
SGTC_593 1203-0218 61.7 µM 1.05712732630661 0.159764312348075 no 565 0.145226740685639 781 3666956
SGTC_1013 4112-3890 241 µM 1.05558234725542 0.160135925616848 no 566 0.145579534692935 750 705171
SGTC_1727 st034309 9.9045 µM 1.05419280419726 0.16047063421785 no 567 0.145897326925997 824 870305
SGTC_1403 3909-7815 62.9 µM 1.0540751491939 0.160498995545379 no 568 0.145924256333043 705 6615483
SGTC_613 3914-0030 117 µM 1.05393344458126 0.160533158498543 no 569 0.145956694756726 504 1145395
SGTC_1995 st072814 61.1 µM 1.05346366348477 0.160646449970849 no 570 0.146064269724642 729 5769371
SGTC_1646 st011709 75.6 µM 1.05337290727273 0.160668342574856 no 571 0.146085058087412 701 5757843
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.04975142349243 0.161543522503807 no 572 0.146916207132992 724 5355888
SGTC_3050 9093513 49.47 µM 1.04814648546775 0.161932369254356 no 573 0.147285560915135 765 25236664
SGTC_765 1319-0117 244 µM 1.04749385656487 0.162090663389018 no 574 0.147435932067214 700 3487746 YGL099W LSG1
SGTC_721 1187-1332 279 µM 1.04154560098521 0.163538046654173 no 575 0.148811200403533 676 25730
SGTC_1547 harmine 94.2 µM 1.04152418290727 0.163543273412848 no 576 0.148816167817271 830 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2062 5245942 200 µM 1.03859365198507 0.164259448040808 no 577 0.149496879680217 794 1376160
SGTC_2591 skatole 100 µM 1.03694793211485 0.16466252587018 no 578 0.149880061861647 751 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2970 9090938 41.86 µM 1.03568504227405 0.1649722733017 no 579 0.15017455138826 834 17217104
SGTC_473 2-arachidonoylglycerol 10 µM 1.03559180210263 0.164995157150017 no 580 0.150196309064997 753 5282280 An endocannabinoid.
SGTC_1545 lovastatin 49.4 µM 1.0343230398953 0.165306752532526 no 581 0.150492584665587 804 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2160 5660466 132.927 µM 1.03254469802277 0.165744136081666 no 582 0.150908509838739 756 2859134
SGTC_2188 6126565 140.678 µM 1.03039404382061 0.166274088554095 no 583 0.151412534048648 723 874518
SGTC_602 3130-1533 38.1 µM 1.02858512018013 0.166720680037795 no 584 0.151837336546016 838 720941
SGTC_2944 9067346 25.62 µM 1.02683109968552 0.16715445530099 no 585 0.152250001226594 743 6473075
SGTC_978 1416-0512 87.4 µM 1.02589526030811 0.167386188974424 no 586 0.152470478503399 805 6814003
SGTC_2091 4-phenylthiadiazole 200 µM 1.02508612568293 0.1675867146583 no 587 0.152661275725575 795 270010
SGTC_203 k066-0004 30.888 µM 1.02465114012964 0.167694579899015 no 588 0.152763912513941 904 6795412
SGTC_1172 0370-0043 85 µM 1.02352680393414 0.167973593474397 no 589 0.153029416658272 763 376585
SGTC_148 3253-0744 288.01 µM 1.02227526267966 0.168284525270341 no 590 0.153325318943456 756 6893655
SGTC_2549 cedrol 20.94 µM 1.02031987899507 0.168771059618668 no 591 0.153788389216785 725 6708665 A sedative which affects the nervous system.
SGTC_653 0203-0016 55.2 µM 1.01979525921955 0.168901748016057 no 592 0.153912786023219 799 295302
SGTC_1964 st076914 61 µM 1.01976834521385 0.168908454335498 no 593 0.153919169614361 796 24208661
SGTC_833 3852-0053 558 µM 1.01382707734254 0.170393060723155 no 594 0.15533263623154 865 3123681
SGTC_546 peri-Naphthalide 147 µM 1.01324227013637 0.170539643052458 no 595 0.15547222733096 780 223824 A penicillin ester.
SGTC_2515 chrysin 20.77 µM 1.01027299507435 0.171285139122693 no 596 0.156182257767196 800 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_628 1636-0253 16 µM 1.00996752125538 0.171361952476212 no 597 0.156255425467793 807 4456143
SGTC_319 1348-1596 45.5 µM 1.00860705301562 0.171704318310941 no 598 0.156581561727194 837 5380505
SGTC_2138 5575593 77.673 µM 1.0084295603049 0.171749017072872 no 599 0.156624143931261 764 762213
SGTC_518 1021-0119 62.6 µM 1.0076059689088 0.171956522923407 no 600 0.156821831152067 745 1097762
SGTC_2532 xanthone 78.9 µM 1.00708328264573 0.172088297987112 no 601 0.156947377032648 717 7020 An insecticide.
SGTC_1744 st037937 38.9 µM 1.0064117747152 0.172257687230494 no 602 0.157108765935815 777 1016152
SGTC_443 clozapine 122 µM 1.00618154135202 0.172315788547732 no 603 0.157164124889001 724 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2131 toluylene red 5.2905 µM 1.00589672332934 0.172387682059153 no 604 0.157232626314713 778 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2488 5268135 45.7 µM 1.00503128667809 0.172606252186436 no 605 0.157440892440573 862 1270356 YLR208W SEC13
SGTC_977 1348-1378 135 µM 1.00280071925205 0.173170406743921 no 606 0.157978510876234 829 X977
SGTC_1897 st060201 15 µM 0.993219988070874 0.175606897484482 no 607 0.160301379810626 747 611878
SGTC_526 4469-0568 170 µM 0.991571117393055 0.176028405007802 no 608 0.160703392194344 785 2901964
SGTC_2543 pimpinellin 60.67 µM 0.991288770800975 0.176100646599559 no 609 0.160772297292299 781 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.989057358783543 0.176672238903861 no 610 0.161317539421281 809 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_68 0986-0284 82.829 µM 0.983243213470371 0.178167077023097 no 611 0.162743875580695 673 423278 YIL048W NEO1
SGTC_2552 juarezic acid 87.02 µM 0.983168572241178 0.178186319242658 no 612 0.162762239862607 977 1549512
SGTC_701 4424-0219 185 µM 0.983056283396012 0.178215269339101 no 613 0.162789869277717 894 2911779
SGTC_2161 5662504 8.5105 µM 0.981416180443836 0.178638455382599 no 614 0.163193775104903 766 2859334
SGTC_2626 ethyl orsellinate 100 µM 0.981358705191412 0.178653296848368 no 615 0.163207941254292 785 75653 A natural product.
SGTC_133 0724-0033 378.92 µM 0.981332042279354 0.178660182104759 no 616 0.163214513237426 785 280309
SGTC_1485 3909-9022 254 µM 0.978074969253911 0.179502524040044 no 617 0.164018623333749 865 714516
SGTC_870 0573-2213 57.6 µM 0.97653636628806 0.179901303177874 no 618 0.164399367776788 794 3916321
SGTC_2233 sulbentine 40.3845 µM 0.974772540810879 0.180359140031623 no 619 0.164836550373831 882 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2914 7968218 45.32 µM 0.974016574383469 0.180555590142692 no 620 0.165024154879866 781 2977111
SGTC_297 0986-0032 24 µM 0.973018160711422 0.180815249673607 no 621 0.165272138110048 794 2847425
SGTC_1292 0kpi-0043 232 µM 0.972807869219444 0.18086997045038 no 622 0.165324400459949 788 3333905
SGTC_116 0155-0182 31.788 µM 0.972647498748494 0.18091170805706 no 623 0.16536426345596 910 771486
SGTC_497 capsazepine 133 µM 0.97162338656995 0.181178383191411 no 624 0.165618971803107 820 2733484 A calcium channel blocker.
SGTC_2057 5236571 38.335 µM 0.971142982710251 0.181303563428594 no 625 0.165738541082238 862 54684039 YBR257W POP4
SGTC_474 dl-dihydrosphingosine 5 µM 0.970529151280567 0.181463590069094 no 626 0.165891400777673 820 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2876 9059903 25.97 µM 0.965665345478818 0.182734714588435 no 627 0.167105832782788 878 6916095
SGTC_3033 9090887 49.47 µM 0.965435518711711 0.182794915566081 no 628 0.167163359154828 854 19325384
SGTC_3167 9103034 49.47 µM 0.964961378073096 0.182919151394356 no 629 0.167282078400717 788 5127859
SGTC_3236 9132701 49.47 µM 0.963853098466366 0.183209751794019 no 630 0.167559790507703 831 24282524
SGTC_73 0327-0325 16.231 µM 0.962433897255106 0.183582298677447 no 631 0.167915846580756 919 53298
SGTC_3062 9077494 49.47 µM 0.962136150279808 0.183660518507739 no 632 0.167990608546978 803 16459633
SGTC_2218 6965428 192.983 µM 0.961973006242159 0.183703386182895 no 633 0.168031581838907 850 675684
SGTC_2964 9083345 53.42 µM 0.961612955353046 0.183798015097332 no 634 0.168122030641873 787 17741579
SGTC_698 k064-0052 127 µM 0.961102108732109 0.183932328379547 no 635 0.168250414761436 852 5088751
SGTC_3005 9076496 71.4286 µM 0.958580999197432 0.184596080631722 no 636 0.168884934196204 834 21368410
SGTC_3049 9092223 49.47 µM 0.957987161133839 0.184752641507281 no 637 0.169034616330126 809 8623917
SGTC_2817 7995342 71.43 µM 0.95640195782875 0.185170972376512 no 638 0.169434597988485 754 18879975
SGTC_3129 9127257 49.47 µM 0.951424432052211 0.186488347605435 no 639 0.17069448131371 716 837894
SGTC_1316 1272-0050 65.9 µM 0.951160642460681 0.186558324976082 no 640 0.170761417150748 830 7340392
SGTC_2211 7117706 200 µM 0.94902359620707 0.187125833962854 no 641 0.171304305581139 823 822771
SGTC_1924 st058459 75.1 µM 0.946707690151362 0.187742044657611 no 642 0.171893875358528 845 688683
SGTC_1797 st048695 56.8 µM 0.942857122082998 0.188769365132928 no 643 0.172876994652299 861 592262 YIL048W NEO1
SGTC_42 0133-0086 60.653 µM 0.942349194920749 0.188905136814874 no 644 0.173006944574745 794 162923 Model of phenazepam hydroxylation.
SGTC_1792 st045773 43.6 µM 0.941788369081064 0.18905511847291 no 645 0.173150500557297 830 2919270
SGTC_3123 9126162 49.47 µM 0.940226841501599 0.189473104060932 no 646 0.17355060820785 848 25239884
SGTC_3238 9133470 49.47 µM 0.939723388789397 0.18960798809647 no 647 0.173679732396839 870 3534688
SGTC_440 fluspirilene 35.1 µM 0.938160236844696 0.190027160917173 no 648 0.17408103474555 863 3396 An atypical antipsychotic.
SGTC_1783 st039459 87.517 µM 0.935327861442362 0.19078813670669 no 649 0.174809680530622 925 729761
SGTC_89 0302-0250 142.109 µM 0.934807798656671 0.190928065170128 no 650 0.17494367989922 928 4203518 YLR208W SEC13
SGTC_1704 st028805 70.8 µM 0.933964232483222 0.191155169519183 no 651 0.175161171710369 846 2876101
SGTC_3246 9135460 32.98 µM 0.932106592078525 0.191655865928008 no 652 0.17564072080184 801 41446951
SGTC_3189 9110682 49.47 µM 0.929919121496353 0.192246491376696 no 653 0.17620648090394 850 17122418
SGTC_2241 6772625 37.8075 µM 0.928721854398741 0.192570229000102 no 654 0.176516625923724 829 2285411
SGTC_1291 0993-0025 5.79 µM 0.928608136570988 0.192600995296358 no 655 0.176546101804105 909 4353356
SGTC_2360 9040895 200 µM 0.927967064353396 0.192774493235462 no 656 0.176712327195079 809 4914414
SGTC_2296 7971656 126.45 µM 0.927296661816313 0.192956031152024 no 657 0.176886263533491 849 666570
SGTC_2262 9014885 67.46 µM 0.924122432463273 0.193816995520692 no 658 0.177711287538023 838 6457424
SGTC_2197 6588183 93.1375 µM 0.921598998474896 0.194503108910189 no 659 0.178368890550037 857 884136
SGTC_2195 6536160 144.242 µM 0.921402744663241 0.194556531560387 no 660 0.17842009816841 796 3834386
SGTC_557 1315-0110 16.2 µM 0.918760546491048 0.195276638806066 no 661 0.179110416468405 912 6833801
SGTC_1622 st003707 19.4 µM 0.917352601027164 0.195661022153297 no 662 0.179478950964864 917 10140899
SGTC_446 go6976 132 µM 0.91603809816692 0.196020309030588 no 663 0.179823456477923 867 3501 A protein kinase C inhibitor.
SGTC_2684 capsaicin 100 µM 0.915844795876133 0.196073177168345 no 664 0.17987415224089 866 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_911 3456-4043 236 µM 0.915477768120192 0.196173582983363 no 665 0.179970434218094 911 914281
SGTC_2107 5363541 170.161 µM 0.914420122549276 0.196463091739445 no 666 0.180248066144331 927 244052
SGTC_1768 st044301 37.178 µM 0.914251548249554 0.196509259403506 no 667 0.180292341714308 915 3931349
SGTC_605 1315-0399 119 µM 0.913923669262499 0.196599074876997 no 668 0.180378477761141 933 24020461
SGTC_298 1391-0729 10 µM 0.910514192796052 0.197534501569887 no 669 0.18127570012267 887 3237558
SGTC_647 0140-0236 81 µM 0.910310307147613 0.197590524935047 no 670 0.181329442160565 987 990837
SGTC_2489 cantharidin 73.42 µM 0.910047853609537 0.197662655627139 no 671 0.181398636741937 884 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_963 1269-2853 151 µM 0.909307236170766 0.197866286974954 no 672 0.181593986007135 870 3668223
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.907773286940946 0.198288446252496 no 673 0.181999007296084 940 3256 An antibiotic and ribosome inhibitor.
SGTC_1796 st049173 110.4 µM 0.906939627937696 0.19851810597874 no 674 0.182219361890365 857 94134
SGTC_1614 st002383 48.6 µM 0.906122396917919 0.198743395734176 no 675 0.182435535978017 898 1947235
SGTC_341 1486-1430 230 µM 0.903011864780851 0.19960229913121 no 676 0.183259798968435 887 2054753 YPL210C SRP72
SGTC_385 1494-0393 12.4 µM 0.900929991430638 0.200178407403753 no 677 0.183812771911097 923 3090647
SGTC_2304 7443016 91.4 µM 0.900912242288423 0.200183323343462 no 678 0.183817490780446 827 939854
SGTC_1686 st019653 115.5 µM 0.897342278592355 0.201173562376576 no 679 0.184768151422301 938 97252
SGTC_2839 9003951 25.97 µM 0.897309575728725 0.201182647075599 no 680 0.184776874108177 894 2990634
SGTC_3154 9100113 49.47 µM 0.895533921783179 0.201676284463013 no 681 0.185250870409835 914 25237525
SGTC_251 melphalan 456.522 µM 0.894385808660937 0.201995849373674 no 682 0.18555775139018 1012 460612 A DNA alkylator.
SGTC_796 1234-0020 70.7 µM 0.893884136509916 0.202135579504014 no 683 0.185691943121873 884 46495034
SGTC_2643 anethole 100 µM 0.893599648824357 0.202214843202185 no 684 0.185768067164445 965 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1057 3448-5381 134 µM 0.890273374150697 0.203142985762458 no 685 0.18665955718425 945 5497911
SGTC_3343 9148379 18.9835 µM 0.888521994792026 0.203632699896108 no 686 0.187130014992592 952 1955036
SGTC_631 k072-0230 41.5 µM 0.888358904388131 0.203678338425665 no 687 0.187173861844437 957 5773147
SGTC_745 0469-0705 296 µM 0.888326971262123 0.203687275170653 no 688 0.18718244780849 1013 3486736
SGTC_1425 4048-4433 7.33 µM 0.888014950524537 0.203774609013507 no 689 0.187266354661453 971 23734946
SGTC_904 1141-0088 396 µM 0.886494786087263 0.204200418523719 no 690 0.187675481258364 895 1378119
SGTC_2915 7971052 15.16 µM 0.884056749021324 0.204884436422689 no 691 0.188332789671197 777 5741558
SGTC_2129 girgensonine 121.053 µM 0.882315196510308 0.205373881119605 no 692 0.188803190401855 968 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3215 9129942 49.47 µM 0.882075950602751 0.205441172832518 no 693 0.188867868257195 883 17682944
SGTC_2775 cyproheptadine 69.59 µM 0.881377286883488 0.205637758038783 no 694 0.189056823482779 982 2913 A selective serotonin reuptake inhibitor.
SGTC_180 1486-1293 102.781 µM 0.88130106828199 0.205659210659094 no 695 0.189077444022251 946 4140536
SGTC_1771 st048882 4.1505 µM 0.879166653267361 0.206260506117378 no 696 0.189655461143348 933 4580403
SGTC_3185 9108267 49.47 µM 0.877829665294904 0.206637685111932 no 697 0.190018081530993 944 4910486
SGTC_2704 st078022 71.1 µM 0.877096020152274 0.206844827915457 no 698 0.190217243099282 951 54697681
SGTC_147 4466-0538 29.23 µM 0.875274036511087 0.207359791645101 no 699 0.190712408788382 1015 6742687 YHR072W ERG7
SGTC_525 k781-2675 26.7 µM 0.873830071117119 0.20776845054102 no 700 0.191105400748018 950 3651118 YDL195W SEC31
SGTC_2126 5251174 33.877 µM 0.872238870906004 0.208219329075421 no 701 0.19153903901838 1018 790722
SGTC_1453 4237-0541 195 µM 0.870773103194279 0.208635175785698 no 702 0.191939027008532 968 739892
SGTC_2906 7926292 26.41 µM 0.869641344435332 0.20895659692079 no 703 0.192248218028418 958 2966319
SGTC_1724 st037281 8.293 µM 0.868065855047344 0.209404523498302 no 704 0.192679141010419 925 574124 YDL195W SEC31
SGTC_1675 st018485 24.5 µM 0.866597782031773 0.209822418671097 no 705 0.193081214607383 945 3323024
SGTC_783 0848-0141 92.7 µM 0.865960727891145 0.210003912104374 no 706 0.193255849284724 897 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2237 6667747 47.222 µM 0.865329223502574 0.210183915454451 no 707 0.193429057727691 890 729940 YDL015C TSC13
SGTC_2332 7982454 138.89 µM 0.865179528350002 0.210226597687076 no 708 0.193470129858499 952 2981748
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.865005098418442 0.210276338910986 no 709 0.193517995226363 926 6708514
SGTC_1315 1237-0019 3.69 µM 0.864205997245947 0.210504302533951 no 710 0.193737369140642 985 825140
SGTC_1180 1193-0155 285 µM 0.863373456221203 0.210741959922713 no 711 0.193966084352452 912 2921347
SGTC_3252 9135871 49.47 µM 0.862390042820126 0.211022888037499 no 712 0.19423645900031 955 17682838
SGTC_2999 9069765 71.4286 µM 0.862218246322301 0.211071987030442 no 713 0.194283715389784 985 2097066
SGTC_772 k072-0172 35.3 µM 0.86143618475907 0.211295582799139 no 714 0.194498927015209 893 5861980
SGTC_191 3914-0123 66.505 µM 0.860455026504878 0.211576297575815 no 715 0.194769132183853 829 3144412
SGTC_1644 st010134 20.9 µM 0.858735914241464 0.212068671117224 no 716 0.195243115706597 952 3818134
SGTC_936 3005-4620 401 µM 0.857637779971081 0.212383539810225 no 717 0.195546253365515 995 777207
SGTC_629 3448-6466 76.7 µM 0.857480440883214 0.212428676103626 no 718 0.195589709886657 979 573744
SGTC_1106 tegaserod maleate 11.7 µM 0.85522672624309 0.213075820214606 no 719 0.196212821567282 969 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2627 acetyl isogambogic acid 100 µM 0.854290518160615 0.213344985938597 no 720 0.196472019779708 940 6857789 A caspase activator and apoptosis inducer.
SGTC_72 0744-0168 198.391 µM 0.85316946829672 0.213667555495891 no 721 0.196782666060977 929 677577
SGTC_3305 9127027 53.8275 µM 0.852143962050062 0.213962882119891 no 722 0.197067097258172 957 41905295
SGTC_3115 9123671 49.47 µM 0.85178604398422 0.214066011744516 no 723 0.197166426834606 1039 3286988
SGTC_891 0929-0073 133 µM 0.850508791834647 0.214434271759251 no 724 0.19752113726789 987 5603632
SGTC_1901 st060216 58.6 µM 0.849654375879213 0.214680824262765 no 725 0.197758635516985 1026 688792
SGTC_1606 st000094 49.2 µM 0.846685384867132 0.215538843893727 no 726 0.198585253566962 1039 1242210
SGTC_2171 5739187 198.077 µM 0.846674246220476 0.215542066632374 no 727 0.198588358676069 953 2262761
SGTC_517 1365-0151 113 µM 0.845237036175149 0.215958128218642 no 728 0.198989253862878 939 768657
SGTC_2029 5175081 200 µM 0.842017889144006 0.216891733756269 no 729 0.199888970081287 1040 1380876
SGTC_847 0342-0274 5.54 µM 0.838739191263106 0.217845003930868 no 730 0.200807840329917 1021 18097
SGTC_1196 1588-0294 184 µM 0.837404811988824 0.218233660927749 no 731 0.201182530924533 933 6144269
SGTC_2533 agelasine 13.65 µM 0.836181759423981 0.218590243109754 no 732 0.201526329194766 1020 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2099 5377090 177.372 µM 0.834739950796504 0.219011034314115 no 733 0.201932071246124 952 2243829
SGTC_1431 4049-0260 9.09 µM 0.834040345199306 0.219215381650099 no 734 0.202129124643512 1004 3854841
SGTC_1966 st070145 16.1 µM 0.833890877736133 0.219259053707609 no 735 0.202171239092049 987 3748532
SGTC_1625 st003711 30.1 µM 0.832321242595206 0.219717978479873 no 736 0.202613821667695 997 24207034 YER133W GLC7
SGTC_1550 gossypolone 36.6 µM 0.830758856165223 0.220175331093679 no 737 0.203054934943064 1040 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1735 st034310 56.75 µM 0.830461711198854 0.2202623751845 no 738 0.203138893630863 966 871153
SGTC_2749 bexarotene 57.39 µM 0.829862519555641 0.220437959244061 no 739 0.203308259008458 962 82146 An retinoic acid receptor inhibitor.
SGTC_2623 humulene 100 µM 0.829842094270341 0.220443945978922 no 740 0.203314033831708 884 6187145 An anti-inflammatory.
SGTC_363 0455-0021 3.06 µM 0.828513527977418 0.220833554314735 no 741 0.203689868444535 1000 4597466
SGTC_1038 k292-0204 154 µM 0.828000352559216 0.220984150921889 no 742 0.20383515011548 936 4454212
SGTC_1789 tunicamycin 25 nM 0.8278366768428 0.221032195606234 no 743 0.203881500243977 999 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_792 4534-1957 155 µM 0.823290326577086 0.222369099300814 no 744 0.205171456640348 1001 1717904
SGTC_1834 st055981 52.8 µM 0.822341001856467 0.222648839554647 no 745 0.205441423593957 1018 471719 YDL150W RPC53
SGTC_756 0508-1999 28.3 µM 0.822073437185741 0.222727719830273 no 746 0.205517551157945 966 6753853
SGTC_3004 9076122 71.4286 µM 0.820931174496309 0.22306464738719 no 747 0.205842736342734 1012 44782551
SGTC_321 4534-3890 65.3 µM 0.819310107421611 0.223543303356444 no 748 0.20630475367105 1042 699746
SGTC_2866 9034245 58.44 µM 0.818469757271034 0.223791665094839 no 749 0.20654450200086 1029 6462273
SGTC_2753 fluvastatin 17.09 µM 0.818310488043851 0.223838754078915 no 750 0.206589959431288 991 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1518 st038567 90.8 µM 0.817777973660828 0.223996236308146 no 751 0.206741988719617 1015 77966
SGTC_1762 st045503 25.4615 µM 0.816577289786051 0.224351549375878 no 752 0.207085018880204 1053 4645554
SGTC_2139 5578692 56.4705 µM 0.816302577994504 0.224432888571197 no 753 0.207163550151057 992 650991 YMR113W FOL3
SGTC_2243 6634756 200 µM 0.81576889379332 0.224590954529787 no 754 0.207316163651158 972 885676
SGTC_798 1287-0182 476 µM 0.814844227261706 0.224864970622758 no 755 0.207580740625477 1082 1649755
SGTC_195 4234-0266 16.654 µM 0.81273497138822 0.225490737190458 no 756 0.208185013059456 1037 2303354
SGTC_1610 st001799 48.1 µM 0.812239266665176 0.225637944032238 no 757 0.208327176052408 931 621897
SGTC_1944 st076371 56.9 µM 0.81176058864955 0.225780146134081 no 758 0.20846451029651 973 24208455
SGTC_2894 9048625 32.47 µM 0.809954992412118 0.226316995211409 no 759 0.208983021888244 1039 4092861
SGTC_820 1582-0060 59.9 µM 0.808646000485857 0.226706641789728 no 760 0.209359398546784 997 3848840
SGTC_2939 9044578 71.43 µM 0.808386332566162 0.226783981904474 no 761 0.209434108688792 1014 2653634
SGTC_2522 biochanin a 4.94 µM 0.808145146733352 0.226855830602883 no 762 0.20950351532183 1012 5280373 A possible chelator.
SGTC_1468 k284-1086 134 µM 0.807939082383424 0.226917226863903 no 763 0.209562825678236 1068 15996457
SGTC_1939 st074455 53.6 µM 0.805374410145011 0.22768214707417 no 764 0.210301827055817 1017 1644229
SGTC_1559 coumarin 343 70.1 µM 0.805102598157095 0.22776330069463 no 765 0.21038023831647 995 108770 A hepatotoxic, DNA x-linker.
SGTC_1922 5578187 25 µM 0.804316729664459 0.227998025290951 no 766 0.210607039117198 1019 1350412
SGTC_1680 diphenhydramine 100 µM 0.80319931854606 0.228332009784728 no 767 0.210929769664096 991 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2610 ononetin 44.17 µM 0.802172502791912 0.228639158382734 no 768 0.211226589964758 1014 259632
SGTC_1294 1000-1494 117 µM 0.801666207605995 0.228790690449107 no 769 0.211373034097234 1020 712797 YDL207W GLE1
SGTC_3131 9127911 49.47 µM 0.801592836118106 0.228812654909673 no 770 0.211394261478836 1000 45595681
SGTC_2079 5212404 121 µM 0.799982787872159 0.229294936200821 no 771 0.211860384825766 1060 758462
SGTC_2712 st079126 47.7 µM 0.799419948982689 0.229463665904754 no 772 0.212023473447641 1021 3152970
SGTC_1056 3448-1962 115 µM 0.798544551779027 0.229726233590888 no 773 0.212277275049671 992 715507
SGTC_2175 5807670 165.306 µM 0.798242007878342 0.229817018080774 no 774 0.212365032077112 1036 241186
SGTC_3197 9113331 49.47 µM 0.797665541578172 0.229990054182161 no 775 0.21253230273904 1027 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_543 3844-1095 191 µM 0.795158556437835 0.230743415579743 no 776 0.213260638000368 1059 4230703
SGTC_378 3970-0959 8.33 µM 0.794075219362888 0.231069389752858 no 777 0.213575821462877 1036 6615653
SGTC_3277 9138724 49.47 µM 0.793547292560591 0.231228335071198 no 778 0.213729513516638 933 15943418
SGTC_2555 cholic acid 100 µM 0.79252409265622 0.231536568113678 no 779 0.214027574707097 1023 6708657 Influences liver metabolism.
SGTC_892 0929-0076 29 µM 0.791819063359765 0.231749087320151 no 780 0.21423309256127 1074 5751038
SGTC_410 α-linolenic acid 100 µM 0.79164514063416 0.23180153010336 no 781 0.214283809132226 1065 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_611 3453-1652 23.7 µM 0.791170554254804 0.23194466538938 no 782 0.214422235966987 1081 1560575
SGTC_1024 4507-0395 26 µM 0.789469281697183 0.23245817356101 no 783 0.214918888398495 1013 4201836
SGTC_3111 9122088 49.47 µM 0.789461199824017 0.232460614482853 no 784 0.214921249332856 964 16876704
SGTC_2445 5742597 35.57 µM 0.789341222325248 0.232496852275781 no 785 0.214956299786126 1009 1774255
SGTC_433 pimozide 108 µM 0.789141109270219 0.232557301059995 no 786 0.215014768577977 1021 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1527 coumarin 137 µM 0.788172052660173 0.232850150640801 no 787 0.215298036984735 1010 323 A hepatotoxic, DNA x-linker.
SGTC_2514 salinomycin 42.74 µM 0.78688634808819 0.23323900749789 no 788 0.215674199951609 1118 23682228 A polyether potassium ionophore.
SGTC_2601 securinine 100 µM 0.786630744838832 0.233316356734652 no 789 0.21574902804508 1033 442872 A GABA receptor antagonist.
SGTC_1063 disulfiram 1.84 µM 0.786625142946181 0.233318052107701 no 790 0.215750668172969 1069 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2257 7960413 200 µM 0.785292873290937 0.233721448146078 no 791 0.216140936660484 1080 2974689 YIL048W NEO1
SGTC_775 4577-0580 57.3 µM 0.783857266560952 0.234156565891831 no 792 0.21656193347231 1071 2006902
SGTC_1137 ixabepilone 100 µM 0.781912488576193 0.234746722943059 no 793 0.217133002529377 1045 154225 A novel microtubule stabilizer.
SGTC_1165 k072-0275 30.3 µM 0.781080421168824 0.234999470818318 no 794 0.217377598208271 1070 6153523 YGL055W OLE1
SGTC_748 act1.228 77.9 µM 0.7793391037784 0.23552889769629 no 795 0.217889992795962 1054 4421505 YNR035C ARC35
SGTC_2883 9059145 45.46 µM 0.77791961218813 0.235960963683176 no 796 0.218308202774187 1083 16476510
SGTC_2802 7925815 54.55 µM 0.776971106080698 0.236249914014178 no 797 0.218587908770162 1052 1262923
SGTC_18 0111-0177 500 nM 0.77537085829325 0.236737850555252 no 798 0.219060274950675 1175 721752
SGTC_1087 pterostilbene 9.05 µM 0.774730999114116 0.236933107019491 no 799 0.219249314757023 1087 5281727 Similar to reservatol, lowers cholesterol.
SGTC_842 0271-0008 11.1 µM 0.774646774917994 0.236958815076906 no 800 0.219274204910328 1094 1221709
SGTC_2750 bromebric acid 70.15 µM 0.772038471394333 0.237755715558547 no 801 0.220045821085917 1094 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.771707751772924 0.237856863396365 no 802 0.220143769246586 949 6708630 An antioxidant.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.770504639106285 0.238225024359807 no 803 0.220500302112583 1146 91467 include heat shock
SGTC_1649 st011737 51.3 µM 0.769363898787999 0.238574387080572 no 804 0.220838656824279 1046 1761035
SGTC_202 3594-0513 34.79 µM 0.769274686316873 0.238601721078225 no 805 0.220865130641637 1067 708429
SGTC_2037 5169046 200 µM 0.765162233038287 0.23986360311129 no 806 0.222087472836001 1070 5718022
SGTC_276 colchicine 750 µM 0.764098093554085 0.240190719894152 no 807 0.222404394161767 1126 2833 A microtubule depolymerizer.
SGTC_2044 5102272 200 µM 0.763596818274581 0.240344896257806 no 808 0.2225537729682 1052 592666
SGTC_2936 9038235 15.59 µM 0.762795418836607 0.24059149324078 no 809 0.222792706832404 1106 4749415
SGTC_969 1313-0238 134 µM 0.762395648436758 0.240714557248854 no 810 0.22291195131629 1113 5212874
SGTC_2731 amoxapine 43.43 µM 0.762224926401361 0.240767122197227 no 811 0.222962885775313 1105 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1188 1403-0014 4.57 µM 0.762050043231505 0.240820974825821 no 812 0.223015068570348 1124 9614867
SGTC_1062 mesoridazine 14.2 µM 0.760861088517221 0.241187269133231 no 813 0.223370021064554 1106 4078 A neuroleptic.
SGTC_423 5-fluorouracil 457 µM 0.7600402264755 0.24144033770622 no 814 0.22361527003787 1060 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2884 9058502 51.95 µM 0.758032799607463 0.242059826799968 no 815 0.224215673698873 1099 6471554
SGTC_3007 9078383 71.4286 µM 0.758007206088933 0.242067730484508 no 816 0.224223334399471 1100 6496995
SGTC_1247 0448-0043 5.84 µM 0.757163596001978 0.242328328975992 no 817 0.224475928546765 1119 3089013 YGL099W LSG1
SGTC_1036 k216-0215 33.5 µM 0.755572503925146 0.242820244636068 no 818 0.224952773316871 1096 622330
SGTC_1579 chlormadinone acetate 49.4 µM 0.755222493550123 0.242928529311764 no 819 0.225057747198311 1132 45114258 A steroidal progestin.
SGTC_2911 7942208 15.64 µM 0.751474658666669 0.244089653942713 no 820 0.22618352309509 1089 1243384
SGTC_435 c-PAF 6.7 µM 0.751087900027307 0.244209646596622 no 821 0.226299878635989 1097 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1602 st001878 87.6 µM 0.750594509048286 0.244362768303243 no 822 0.226448363366155 1096 595405 YLR310C CDC25
SGTC_710 3448-4187 58 µM 0.750176710130014 0.244492470795273 no 823 0.226574141868498 1136 3946412
SGTC_2106 5357045 167.29 µM 0.749979557082106 0.24455368833497 no 824 0.226633508551862 1107 668842
SGTC_2837 9008476 45.46 µM 0.749179716405965 0.244802129695314 no 825 0.226874446444219 1131 2992805
SGTC_1647 st011722 22.4 µM 0.748450973919789 0.245028605219851 no 826 0.227094092996427 1087 2854783
SGTC_325 2810-4341 181 µM 0.748057953704483 0.245150793158182 no 827 0.227212600957651 1123 774970
SGTC_2608 thymoquinone 42.66 µM 0.747686137179779 0.245266419135763 no 828 0.22732474741652 1042 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2568 diosmetin 100 µM 0.746844905711824 0.245528130014659 no 829 0.227578592817854 1127 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2325 6158266 200 µM 0.746768388694865 0.245551942242727 no 830 0.227601690090482 1122 3623240
SGTC_2713 st079149 53.4 µM 0.744215641153338 0.246347072296487 no 831 0.228373013458483 1112 3103253
SGTC_1953 st076800 12.1 µM 0.743483369045433 0.246575414947526 no 832 0.228594543363269 1045 297591
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.742337821975774 0.246932855432468 no 833 0.228941340836114 1129 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1266 0828-0227 32.9 µM 0.741656611149121 0.247145542333288 no 834 0.229147707264163 1080 3913820
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.741237006512353 0.247276599581784 no 835 0.229274874457705 1149 94937 An inhibitor of serotonin biosynthesis.
SGTC_2450 5739737 12.93 µM 0.739822635587748 0.247718630808963 no 836 0.229703811157962 1098 2262825
SGTC_2395 5646831 180.19 µM 0.73784669961472 0.248336872940098 no 837 0.230303805686075 1116 6808628
SGTC_2324 6149169 200 µM 0.737797159356095 0.248352383941947 no 838 0.23031885987839 1080 2888231
SGTC_2734 clemastine 41.6 µM 0.737709320441998 0.248379887481343 no 839 0.230345553540433 1070 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2862 9027634 71.43 µM 0.737530003412839 0.248436039082368 no 840 0.23040005216343 1101 5012562
SGTC_2480 5767542 37.17 µM 0.737297737242918 0.248508781311598 no 841 0.230470653978676 1145 2867358
SGTC_708 3448-5400 146 µM 0.736851097153182 0.248648694078081 no 842 0.230606452892491 1141 3462195
SGTC_2117 5521686 200 µM 0.736290386096141 0.248824399660173 no 843 0.23077699785217 1132 803312
SGTC_2387 9077560 195.08 µM 0.736250734231205 0.248836827552948 no 844 0.230789060965119 1116 5303272
SGTC_1662 st014054 52 µM 0.73605884421806 0.248896975382945 no 845 0.23084744379799 1159 2838777
SGTC_676 falcarinol 140 µM 0.735466182593534 0.249082793725215 no 846 0.23102781407669 1168 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2421 5690543 90.72 µM 0.734441821316491 0.249404137625921 no 847 0.23133975296792 1118 3397993
SGTC_206 4546-0025 72.014 µM 0.733454589831298 0.249714042235936 no 848 0.231640607242498 1163 6620745 YIL048W NEO1
SGTC_229 benomyl 22.8748 µM 0.733311643293633 0.249758931928249 no 849 0.23168418761018 1136 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3199 9111318 49.47 µM 0.732857637145869 0.2499015324968 no 850 0.231822631574947 1078 8548020
SGTC_1011 4112-3381 17.4 µM 0.73223284513072 0.250097846502187 no 851 0.232013230054246 1152 2877139
SGTC_1769 st044406 64.4 µM 0.731559487841987 0.250309511616328 no 852 0.23221874146048 1128 670903
SGTC_2674 ligustilide 100 µM 0.731015281520599 0.250480648406751 no 853 0.232384909453667 1093 5319022 A signalling regulator.
SGTC_323 4013-0906 34.3 µM 0.729451185129187 0.250972855441548 no 854 0.232862858764332 1163 2910086
SGTC_1721 st082152 9.2685 µM 0.728601889400855 0.251240335413778 no 855 0.233122611213229 1127 5296051
SGTC_1286 0929-0070 131 µM 0.727788939143628 0.25149650976145 no 856 0.233371398210227 1181 1420408
SGTC_391 gliotoxin 8.33 µM 0.727264392337935 0.251661876545687 no 857 0.233532003317027 1161 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1991 st073000 8.92 µM 0.727023716599621 0.2517377703497 no 858 0.233605713633672 1172 4301969 YIL048W NEO1
SGTC_1303 1160-0052 261 µM 0.726379836459597 0.251940868552048 no 859 0.233802974355235 1174 3562476
SGTC_1464 k208-0027 110 µM 0.724149973446799 0.252644898862364 no 860 0.234486833666201 1138 X1464
SGTC_458 nppb 133 µM 0.722913965345395 0.253035587204849 no 861 0.234866371533382 1144 4549 A chloride channel blocker.
SGTC_1932 st074806 40.9 µM 0.722130012690044 0.25328355051552 no 862 0.235107273740655 1264 17251235
SGTC_1053 3366-3204 134 µM 0.721687018886243 0.253423725410898 no 863 0.235243462422855 1136 3632071 YPR165W RHO1
SGTC_150 3970-0969 77.2 µM 0.721321206721525 0.253539508731837 no 864 0.235355956138847 1140 6615640
SGTC_1557 sumaresinolic acid 42.3 µM 0.72096115453067 0.253653496094596 no 865 0.235466707550876 1114 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1617 st002906 78 µM 0.720886657016359 0.253677084299966 no 866 0.235489626443769 1152 5150859
SGTC_126 0417-1624 672.48 µM 0.718663703272955 0.254381469561327 no 867 0.23617407625357 1271 41912 YDL195W SEC31
SGTC_2973 9094665 17.96 µM 0.716954385232585 0.254923795923549 no 868 0.236701121424879 1185 25237061 YIL048W NEO1
SGTC_2411 st077133 39.94 µM 0.714926027756092 0.255568130111435 no 869 0.237327376535625 1213 1403142 YNL221C POP1
SGTC_2205 7238770 200 µM 0.714752072731739 0.255623428771876 no 870 0.237381127457464 1176 279867
SGTC_2447 5741742 33.78 µM 0.714340045712173 0.255754433198189 no 871 0.237508467671656 1175 1776504
SGTC_735 3076-0345 636 µM 0.713685492333057 0.255962621184392 no 872 0.237710839649814 1189 2888990
SGTC_2763 lisinopril 49.32 µM 0.712602155519082 0.256307382691274 no 873 0.238045988775982 1138 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2885 9057732 51.95 µM 0.712337210427242 0.256391735736345 no 874 0.23812799355651 1195 6471414
SGTC_3088 9117578 49.47 µM 0.711955516952623 0.256513284483878 no 875 0.238246161056121 1227 678341
SGTC_2816 7982706 58.44 µM 0.709252596844856 0.25737487663811 no 876 0.239083869601597 1169 2981853
SGTC_1332 1480-0653 17.5 µM 0.708020072588322 0.257768258953882 no 877 0.23946639624023 1169 5749438
SGTC_711 k292-0785 179 µM 0.70801615589969 0.257769509532858 no 878 0.23946761235748 1207 4146315
SGTC_397 arbidol 50 µM 0.707641867093352 0.257889032594052 no 879 0.239583843197982 1199 131410 A RNA synthesis inhibitor.
SGTC_2145 5634607 200 µM 0.706778186942799 0.258164944540375 no 880 0.239852166054578 1147 308662
SGTC_689 0833-0039 98 µM 0.706221300000882 0.258342929203978 no 881 0.240025263163295 1183 5374726
SGTC_2937 9044753 11.33 µM 0.703467440745854 0.259224014153906 no 882 0.240882245310712 1207 6465530 YGL099W LSG1
SGTC_1168 k815-0004 80.5 µM 0.702073957465352 0.259670443949736 no 883 0.241316521167426 1179 642433
SGTC_24 0417-1663 219 µM 0.7019039102575 0.259724949076132 no 884 0.241369545097703 1172 4329390
SGTC_3193 9111931 49.47 µM 0.700495568761395 0.260176590752005 no 885 0.241808935771383 1226 17087244
SGTC_1322 1348-1070 12 µM 0.698382681498411 0.260854931932905 no 886 0.242468952043268 1176 6758089
SGTC_1596 piperlongumine 63 µM 0.696048273241003 0.261605448706661 no 887 0.243199299474563 1207 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_406 estrone 100 µM 0.695668085723975 0.261727784593182 no 888 0.243318358187514 1205 5870 A steroid.
SGTC_2364 9055074 200 µM 0.695638910030697 0.261737173894847 no 889 0.24332749608672 1172 6470630
SGTC_853 0419-0306 21 µM 0.695486484032451 0.261786230335118 no 890 0.24337523930133 1149 762713
SGTC_2293 7624732 200 µM 0.694890574948621 0.261978061627634 no 891 0.243561939856643 1184 894453
SGTC_1158 4092-0494 91.8 µM 0.693381557653594 0.262464157069043 no 892 0.244035066405714 1257 1148199
SGTC_877 0771-0151 33.1 µM 0.693330345313676 0.262480662051734 no 893 0.24405113185158 1191 6166523
SGTC_712 r015-0009 80.6 µM 0.69320820646025 0.262520027749432 no 894 0.24408944943402 1154 6813872 YLR060W FRS1
SGTC_799 1310-0557 151 µM 0.689575963612612 0.263692089528819 no 895 0.245230443641396 1221 5354492
SGTC_1444 4112-3581 28 µM 0.688721458471942 0.263968210845437 no 896 0.245499284875183 1231 2877249
SGTC_211 3455-0679 143.504 µM 0.687063393597498 0.264504411249742 no 897 0.246021390479538 1231 748649
SGTC_1794 st048918 76.9 µM 0.686390243107046 0.264722258972835 no 898 0.246233527738121 1151 672303
SGTC_3312 9133330 71.43 µM 0.685604732454333 0.264976584454589 no 899 0.246481198228744 1228 17617324
SGTC_919 tnp00227 403.569 nM 0.685491757784656 0.265013172573277 no 900 0.246516829971811 1216 1269246 A methoxyflavone. YNL221C POP1
SGTC_407 eburnamonine 100 µM 0.685228462770616 0.265098453588683 no 901 0.246599882838641 1121 3195
SGTC_2770 toltrazuril 17.5 µM 0.683776130537581 0.265569113051414 no 902 0.247058270708376 1200 68591 Kills coccidiodes.
SGTC_2081 5214970 32.255 µM 0.683336220993784 0.265711758777975 no 903 0.247197205689679 1181 2063512
SGTC_1179 1021-1431 9.29 µM 0.682906713944249 0.265851068845688 no 904 0.247332895591374 1201 2840958
SGTC_3202 9113761 49.47 µM 0.681347777119657 0.26635701883243 no 905 0.247825729376972 1247 4798415
SGTC_486 niguldipine 82 µM 0.680482640420015 0.266638007380066 no 906 0.24809945499703 1222 1236 A calcium channel blocker.
SGTC_994 3910-0338 138 µM 0.678921581770051 0.267145403963549 no 907 0.248593775166758 1276 3479481
SGTC_104 0074-0074 590.992 µM 0.678296267582325 0.267348788752647 no 908 0.248791932364852 1091 3943124
SGTC_2843 9000894 45.46 µM 0.677304178280893 0.267671628142688 no 909 0.24910649021371 1097 2242070
SGTC_2349 9023730 187.07 µM 0.676229486981754 0.268021568913366 no 910 0.249447476923933 1218 4126287
SGTC_3338 9144300 39.5675 µM 0.675992406847956 0.268098797899076 no 911 0.249522733001135 1213 4901274
SGTC_2569 tetrandrine 100 µM 0.675638404361019 0.268214135251859 no 912 0.249635126058809 1196 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_740 k014-0057 261 µM 0.674522921452738 0.268577733323118 no 913 0.24998945906967 1233 4012779
SGTC_14 0354-0009 295 µM 0.670504873035807 0.269889489319221 no 914 0.251268000529449 1273 1713507
SGTC_3262 9137218 49.47 µM 0.669853333830258 0.270102496475356 no 915 0.251475645347348 1109 17650664
SGTC_1814 st052110 31.539 µM 0.669667610671318 0.270163230188653 no 916 0.25153485171472 1226 674163
SGTC_2019 4016004 108 µM 0.668879990965107 0.270420867212977 no 917 0.251786017472147 1202 45595336
SGTC_289 k017-0060 526 µM 0.668321314465035 0.27060368939868 no 918 0.251964255276287 1211 5512909
SGTC_1035 k081-0041 55.2 µM 0.668223534380299 0.270635693455914 no 919 0.251995457469065 1263 731709
SGTC_2642 cholecalciferol 100 µM 0.667711239045453 0.270803401940051 no 920 0.25215896720417 1221 9821465 A vitamin D precursor, similar to steriods.
SGTC_355 1311-2252 105 µM 0.667408878595906 0.270902409051536 no 921 0.252255498097557 1210 5338538
SGTC_1323 1348-1351 11.2 µM 0.666478657709583 0.271207120590843 no 922 0.252552600396969 1200 6989654
SGTC_2463 5473429 200 µM 0.663034618970729 0.272336766303426 no 923 0.253654191213129 1224 5399405
SGTC_398 bronopol 33.3 µM 0.661918220700082 0.272703446289472 no 924 0.254011816905307 1187 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1397 3532-0190 20.1 µM 0.659411130575556 0.273527789550128 no 925 0.254815898266086 1183 5322280
SGTC_1157 4092-0394 27.6 µM 0.659304684351087 0.273562816854969 no 926 0.254850067476713 1341 3659885
SGTC_31 0508-1974 57.237 µM 0.658564340618641 0.273806496522807 no 927 0.255087783953529 1225 6810525
SGTC_467 ro 31-8220 72.8 µM 0.658222209363302 0.273919143211485 no 928 0.255197677821425 1215 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1195 1502-0147 41.1 µM 0.656288948742905 0.274556099262061 no 929 0.255819113385352 1265 817940
SGTC_638 3970-0837 4.09 µM 0.656271681454436 0.274561791648086 no 930 0.255824667413253 1247 4118451 YLR208W SEC13
SGTC_93 0109-0045 59.227 µM 0.655253495806491 0.274897552679119 no 931 0.256152278338805 1316 88733
SGTC_818 4072-2707 53.5 µM 0.654512889995156 0.275141904912009 no 932 0.25639071267937 1209 882871
SGTC_3310 9130229 44.1445 µM 0.654403816902279 0.275177901043764 no 933 0.256425837985135 1277 7761258
SGTC_2703 st077852 53.4 µM 0.653431728494692 0.275498810522715 no 934 0.256738994769037 1256 6281836
SGTC_331 k048-0133 24.5 µM 0.65324774903442 0.275559567223667 no 935 0.25679828586731 1236 6813582
SGTC_2223 6903751 107.57 µM 0.652786704258429 0.275711849896297 no 936 0.256946898163952 1237 5598863
SGTC_2697 mebhydrolin 72.4 µM 0.652352984489771 0.27585514489467 no 937 0.257086743405353 1275 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3077 9117319 49.47 µM 0.650421512611645 0.276493720366238 no 938 0.257709992534994 1264 17154678
SGTC_2560 caryophyllene 100 µM 0.650213638449201 0.27656249006349 no 939 0.257777116282908 1301 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2278 7948257 134.34 µM 0.649018211049077 0.276958128441677 no 940 0.258163302648346 1238 1247028
SGTC_2768 sulfasalazine 50.2 µM 0.647897341975525 0.277329342550181 no 941 0.258525675012866 1335 5384001 An antioxidant and salicylic acid derivative.
SGTC_383 2324-0395 7.37 µM 0.64758822990456 0.277431758363359 no 942 0.258625655996722 1283 3146421
SGTC_2124 5246320 200 µM 0.646933280480251 0.277648818974909 no 943 0.258837562728127 1277 579342
SGTC_2180 6301957 200 µM 0.645340526002654 0.278177028967854 no 944 0.259353267847779 1239 845462
SGTC_948 3448-0295 75.3 µM 0.643918757342134 0.278648948007488 no 945 0.259814058876949 1299 678569
SGTC_50 0929-0078 56.389 µM 0.643752434878152 0.278704179872293 no 946 0.259867991081518 1211 1377751
SGTC_2691 st077356 60.2 µM 0.643488275496711 0.278791912080318 no 947 0.259953660037796 1321 2839272
SGTC_982 1491-0518 27.5 µM 0.639582946942849 0.28009050970547 no 948 0.261221885994065 1258 3091256
SGTC_506 n9-isopropylolomoucine 153 µM 0.638380584327047 0.280490908048369 no 949 0.261612983275 1293 6610355
SGTC_3102 9121669 49.47 µM 0.636187206699075 0.281222036830655 no 950 0.262327205316569 1313 41905072
SGTC_1638 st008370 60.6 µM 0.634713023071928 0.281713949866824 no 951 0.26280779921668 1288 24207134
SGTC_54 0159-0055 9 µM 0.634534718554717 0.281773475527326 no 952 0.262865958214214 1361 3319099
SGTC_2030 5175110 200 µM 0.632466342309606 0.282464430516428 no 953 0.263541097524263 1334 2831986
SGTC_3093 9117344 49.47 µM 0.631236056346408 0.282875801909323 no 954 0.263943094824034 1305 24824913
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.63073841367444 0.283042280651684 no 955 0.264105788852126 1286 688798
SGTC_515 4092-1064 102 µM 0.630389657077583 0.283158979855622 no 956 0.264219838083698 1349 717353
SGTC_2409 alverine citrate 63.97 µM 0.629993147603096 0.283291685927689 no 957 0.264349533765515 1423 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1751 st044839 27.194 µM 0.629145529635643 0.28357547157688 no 958 0.264626892765769 1297 5291326
SGTC_2652 actinonin 100 µM 0.62830004746236 0.283858677777372 no 959 0.264903700277256 1277 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1257 0669-0121 16 µM 0.627191457672934 0.284230220606751 no 960 0.265266871022935 1326 4307855
SGTC_1380 2291-0730 164 µM 0.626551980882523 0.284444646340371 no 961 0.265476476630819 1287 2999191
SGTC_3352 9151559 45.5865 µM 0.625739530459848 0.284717184027259 no 962 0.265742900115502 1264 17159339
SGTC_615 k087-0205 167 µM 0.623022434987498 0.285629541999984 no 963 0.266634889490443 1254 9642773
SGTC_5 0352-0601 109.883 µM 0.622409938261324 0.285835400768377 no 964 0.266836173587852 1222 762456
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.621549754934464 0.286124625504352 no 965 0.26711898421748 1306 521171
SGTC_225 nsc-122657 1.016 µM 0.619794341126199 0.286715290078407 no 966 0.267696597387472 1285 275685
SGTC_2898 9056270 58.44 µM 0.619701202377319 0.286746645704053 no 967 0.267727261963746 1251 19154699
SGTC_2987 9018338 71.43 µM 0.619422857686631 0.286840361523404 no 968 0.267818913446307 1349 5055682
SGTC_379 3970-0972 5.9 µM 0.617369100423525 0.287532288929442 no 969 0.268495649127891 1325 2898042 YBL034C STU1
SGTC_2641 levomentholum 100 µM 0.617265536942071 0.287567201192934 no 970 0.268529797192207 1268 16666
SGTC_3280 9140961 49.47 µM 0.615630160728586 0.288118768023313 no 971 0.269069320280439 1303 4901226
SGTC_1343 1487-0095 224 µM 0.614869437005488 0.288375508940428 no 972 0.269320474090792 1318 4560101 YGL055W OLE1
SGTC_2856 9022925 19.48 µM 0.614052789651818 0.288651243821184 no 973 0.269590221927807 1331 4944862
SGTC_2742 clothiapine 36.27 µM 0.609665978628767 0.290134538791557 no 974 0.271041547834246 1310 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_408 cantharidin 100 µM 0.608624943051438 0.290487063704501 no 975 0.271386533747933 1324 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2113 5491891 107.031 µM 0.606774690267803 0.291114107398268 no 976 0.272000223427053 1306 789979
SGTC_819 1013-0258 27.7 µM 0.606445427356353 0.291225759578798 no 977 0.272109505256522 1323 5753198
SGTC_569 4130-2812 160 µM 0.606028699971426 0.29136709938591 no 978 0.272247847692048 1277 743552
SGTC_2418 pentamidine 31.67 µM 0.604527826495864 0.291876409850547 no 979 0.272746387306725 1292 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1290 0986-0249 10.2 µM 0.603595609389722 0.292192959550927 no 980 0.273056266306606 1294 53329
SGTC_2071 5230951 39.92 µM 0.603012740389245 0.292390963461736 no 981 0.273250106864799 1346 1799272
SGTC_931 2812-0076 566 µM 0.600636366698004 0.293198876048878 no 982 0.274041105202042 1351 3450959
SGTC_1218 1348-1416 30.7 µM 0.598462328732907 0.293938904434561 no 983 0.274765743884245 1334 6787668
SGTC_2910 7948405 25.97 µM 0.597047588866656 0.29442093612507 no 984 0.275237804249966 1360 2971328
SGTC_1484 3473-2379 286 µM 0.596952745590291 0.294453264276378 no 985 0.27526946515606 1422 671917
SGTC_3103 9120822 49.47 µM 0.595882727563635 0.294818102643906 no 986 0.27562678637582 1404 17141819
SGTC_1350 1495-0454 146 µM 0.595723125406305 0.294872539199422 no 987 0.275680103369149 1396 1069057
SGTC_320 4092-0846 5.34 µM 0.59564693243831 0.29489852846882 no 988 0.27570555832148 1376 1359356
SGTC_2232 chlorophetanol 41.5365 µM 0.595377444740783 0.294990458653721 no 989 0.275795599474493 1400 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2313 7726885 200 µM 0.594743524647611 0.295206759495065 no 990 0.276007461634857 1337 726423
SGTC_527 4476-4215 268 µM 0.594602325014962 0.295254948377967 no 991 0.276054662784348 1369 4418754
SGTC_2886 9058944 51.95 µM 0.592125165921233 0.296100946305487 no 992 0.276883388045068 1247 4949929
SGTC_491 tetrandrine 80.3 µM 0.590450238717472 0.296673596058086 no 993 0.277444418841821 1398 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2050 5263056 171 µM 0.588425682077091 0.297366458694565 no 994 0.278123301850531 1346 763468 YGL055W OLE1
SGTC_450 aminopyrene 156 nM 0.587888948685704 0.297550268482054 no 995 0.278303417373353 1361 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3325 9138760 55.175 µM 0.585980955889776 0.2982040994594 no 996 0.278944156326466 1315 43844959
SGTC_1669 st015249 58.4 µM 0.585385768589403 0.298408192057829 no 997 0.279144177874966 1420 722793
SGTC_2331 7980721 200 µM 0.58153243011578 0.299731055621082 no 998 0.280440833958311 1384 2981221
SGTC_2217 6934799 96.0675 µM 0.579648149985293 0.300378900570391 no 999 0.281075957770413 1357 675606
SGTC_368 fentichlor 4.58 µM 0.57864792071079 0.30072305188992 no 1000 0.281413381582504 1336 7329 A pesticide.
SGTC_1020 4335-0961 93.3 µM 0.578056242510666 0.300926715771392 no 1001 0.281613074105423 1309 669075
SGTC_2052 5265182 7.135 µM 0.577951298188094 0.300962845562894 no 1002 0.281648500148702 1431 1239884
SGTC_1981 st071826 47 µM 0.577864016327029 0.300992896085843 no 1003 0.281677965513551 1332 11838600
SGTC_2709 st078560 56 µM 0.577097572764638 0.301256835214897 no 1004 0.281936771962705 1437 17250903
SGTC_2098 5376439 882.5 nM 0.575054572130852 0.301960889277284 no 1005 0.282627194950127 1456 2844116
SGTC_3200 9114385 49.47 µM 0.575050722318572 0.30196221668801 no 1006 0.282628496743826 1334 17018030 YLR208W SEC13
SGTC_129 0088-0017 176.636 µM 0.575041352180792 0.301965447511401 no 1007 0.282631665218494 1333 182446
SGTC_2342 7990637 118.86 µM 0.574432792006417 0.302175312296327 no 1008 0.282837483963461 1415 2033102 YER133W GLC7
SGTC_2354 9060492 162 µM 0.572529295300768 0.302832164148464 no 1009 0.283481722436236 1437 6471895
SGTC_330 1488-0319 80.1 µM 0.571644290840729 0.303137775896912 no 1010 0.283781491526758 1392 6846614
SGTC_2352 9027995 87.8 µM 0.570794200150371 0.303431460958042 no 1011 0.284069577447522 1392 2997347
SGTC_1697 st025554 27.742 µM 0.567148091044253 0.304692539577881 no 1012 0.285306785920879 1366 1269519
SGTC_2108 5365811 200 µM 0.566987771364924 0.30474804274955 no 1013 0.285361244928476 1455 780283
SGTC_2244 6635614 200 µM 0.566180765736318 0.305027498838008 no 1014 0.28563545190902 1371 836499
SGTC_1510 1123-0200 71.5 µM 0.565826272011559 0.305150291604182 no 1015 0.285755942554097 1499 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_979 1426-2828 121 µM 0.563122868339923 0.306087441939473 no 1016 0.286675610214716 1460 747872
SGTC_3271 9137798 49.47 µM 0.561605358026259 0.306614052784283 no 1017 0.287192464517857 1382 6498326
SGTC_2929 9013348 24.6 µM 0.558881867363347 0.307560167874259 no 1018 0.288121172608405 1408 2995952
SGTC_1907 st060210 83.7 µM 0.558363594567745 0.307740356310199 no 1019 0.288298063571916 1470 688793
SGTC_3071 9117417 49.47 µM 0.557647206112952 0.307989500182962 no 1020 0.288542657400707 1388 45595590 YGL055W OLE1
SGTC_1301 naphtanilide LB 4.81 µM 0.556022295600464 0.308554935682098 no 1021 0.289097806622122 1495 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1275 0867-0008 21.1 µM 0.554302904693048 0.309153743161272 no 1022 0.289685781374459 1418 3422836
SGTC_292 k038-0015 474 µM 0.55308217412472 0.309579191700763 no 1023 0.290103571199281 1415 46368540
SGTC_2771 fluoxetine 41.05 µM 0.55269582280174 0.309713895925465 no 1024 0.290235857095229 1450 3386 A selective serotonin reuptake inhibitor.
SGTC_1440 4100-1550 40 µM 0.550469131737142 0.310490745813635 no 1025 0.290998821702095 1414 742806
SGTC_2425 5628681 7.85 µM 0.548982802906386 0.311009768590406 no 1026 0.291508625820114 1450 5714958
SGTC_1491 4138-0063 26.5 µM 0.548962762920729 0.311016769081631 no 1027 0.291515502290322 1393 23883227
SGTC_940 3232-1287 54.8 µM 0.547992507871942 0.311355786315106 no 1028 0.291848523624636 1389 1585493 YIL048W NEO1
SGTC_992 3909-8734 162 µM 0.547414786334429 0.311557724286588 no 1029 0.292046899540984 1408 4288319
SGTC_2513 baicalein 25.65 µM 0.547035004064252 0.311690505050181 no 1030 0.292177341978147 1358 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_359 0081-0058 15.9 µM 0.546452564489604 0.311894187115982 no 1031 0.292377443034282 1568 3494159
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.543018720835214 0.313096187572857 no 1032 0.293558456446496 1401 279621
SGTC_742 0kpi-0133 140 µM 0.542847471510467 0.313156184747114 no 1033 0.293617412589379 1489 2728852
SGTC_757 1066-0008 322 µM 0.542209502606106 0.313379740585091 no 1034 0.293837094890777 1477 6842497
SGTC_997 3996-0078 137 µM 0.539385649898146 0.314370092380421 no 1035 0.29481039031925 1437 735687
SGTC_2391 6285546 200 µM 0.538677328324206 0.314618717554919 no 1036 0.295054760001501 1384 846083
SGTC_1975 st070967 30.8 µM 0.537029124106103 0.315197572549859 no 1037 0.29562374835265 1473 261391
SGTC_1526 st051518 75 µM 0.536545735103333 0.315367426602311 no 1038 0.295790718127286 1432 673993
SGTC_96 0929-0093 37.281 µM 0.534050925309249 0.316244676979751 no 1039 0.296653150641153 1395 6991579
SGTC_123 0083-0120 66.675 µM 0.533443575271305 0.316458396457199 no 1040 0.296863280073598 1364 16001701
SGTC_61 0978-8327 98.565 µM 0.533060804569239 0.316593120554149 no 1041 0.296995745096724 1443 6150059 YHR072W ERG7
SGTC_1642 st009582 77.7 µM 0.532988018687484 0.316618741810976 no 1042 0.297020937083513 1490 6739311
SGTC_637 1181-0519 7.26 µM 0.532512339575834 0.316786206613015 no 1043 0.297185598867318 1425 6252091 YGR060W ERG25
SGTC_429 1112-0049 25.5 µM 0.532345115302769 0.316845087533712 no 1044 0.297243495380131 1386 2836170
SGTC_3323 9138564 53.9225 µM 0.532025029629755 0.316957805038485 no 1045 0.297354330055083 1528 43912313 YNL103W MET4
SGTC_2193 5925765 200 µM 0.531445312731686 0.317161994384704 no 1046 0.297555114152433 1463 877370
SGTC_988 1497-1057 103 µM 0.529820368696775 0.317734632861477 no 1047 0.298118240733513 1480 3533044
SGTC_1371 2421-0008 32.7 µM 0.529201334321659 0.317952898529463 no 1048 0.298332895583402 1460 2827552
SGTC_3221 9128209 49.47 µM 0.52909809465789 0.317989306015184 no 1049 0.298368701561819 1465 16460723
SGTC_3321 9137793 26.8275 µM 0.528929032319199 0.318048929677835 no 1050 0.298427340638134 1435 4904192
SGTC_1193 1488-0126 41.5 µM 0.527731592540747 0.318471368857949 no 1051 0.298842821271526 1452 1384710
SGTC_2333 9017922 200 µM 0.526289788461829 0.318980329466297 no 1052 0.299343438458569 1580 3163164
SGTC_1573 oleylamine 1.06 µM 0.525488065671587 0.319263487516312 no 1053 0.299621973748506 1437 5356789 An amine of the fatty acid oleic acid.
SGTC_1854 st056233 32.9 µM 0.523867394453708 0.319836209423683 no 1054 0.300185387183653 1471 5393174
SGTC_3099 9120367 49.47 µM 0.522901629541809 0.320177701312972 no 1055 0.300521355280989 1440 24824940
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.521711250261974 0.320598825886659 no 1056 0.300935695189973 1501 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2859 9028643 45.46 µM 0.521072520671443 0.32082488673278 no 1057 0.30115812640194 1418 17151580
SGTC_991 3996-0057 64.7 µM 0.520367269707145 0.321074568190245 no 1058 0.301403809027814 1469 715343
SGTC_1470 k295-0292 231 µM 0.52007623687287 0.321177626738821 no 1059 0.301505220094213 1505 5045612
SGTC_2072 5231554 129 µM 0.51784671725189 0.321967585344301 no 1060 0.302282610154715 1521 789545
SGTC_1151 3909-8316 15.3 µM 0.517770817612376 0.321994492133038 no 1061 0.302309090703138 1458 800431
SGTC_3308 9128332 17.569 µM 0.517448552248182 0.322108747152291 no 1062 0.302421537128501 1559 17332805 YDL196W YDL196W
SGTC_3000 9075062 71.4286 µM 0.517150693860801 0.322214363945958 no 1063 0.302525484027012 1440 17057871
SGTC_2946 9065502 71.43 µM 0.516879262776617 0.322310622456883 no 1064 0.302620222245606 1349 16489101
SGTC_581 0958-0271 211 µM 0.516576475340337 0.32241801503642 no 1065 0.30272592052849 1429 4591145
SGTC_622 1348-1566 26.3 µM 0.516360219466094 0.322494725694575 no 1066 0.302801422139809 1527 7340407
SGTC_2845 9003024 42.97 µM 0.516149256841065 0.322569566004705 no 1067 0.302875083838598 1536 2990173
SGTC_23 0213-0011 39.996 µM 0.516097786360463 0.322587826570634 no 1068 0.302893056974139 1523 627608
SGTC_2346 9031566 143.75 µM 0.515830039561403 0.322682823999832 no 1069 0.302986560003856 1526 4771086
SGTC_212 3807-4682 38.772 µM 0.515233352460953 0.322894572142969 no 1070 0.303194982624272 1566 3125501 YBL034C STU1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.514963966834504 0.322990188648492 no 1071 0.303289099941396 1441 688664
SGTC_357 1325-0123 420 µM 0.512983277800359 0.323693578997293 no 1072 0.303981509040413 1496 1098503
SGTC_664 1222-0054 14.9 µM 0.511592628344676 0.324187808877548 no 1073 0.304468072865428 1437 6813991
SGTC_814 3342-0569 96 µM 0.511266419185584 0.324303786900557 no 1074 0.304582257889691 1486 4346283
SGTC_2054 5233173 129 µM 0.511218711396436 0.324320750008808 no 1075 0.304598958940924 1495 6889
SGTC_366 0181-0206 4.31 µM 0.509529554417084 0.324921585922397 no 1076 0.305190543929232 1606 274874
SGTC_717 1532-0246 73.2 µM 0.509509598925142 0.324928686850155 no 1077 0.305197535888117 1436 9561992
SGTC_2320 7373003 200 µM 0.508790326218691 0.32518467405242 no 1078 0.305449600431736 1396 5415828
SGTC_3002 9075603 71.4286 µM 0.508204882245199 0.32539309290216 no 1079 0.305654833661353 1452 20105405
SGTC_1940 st075990 51.1 µM 0.507903359564482 0.325500456699471 no 1080 0.305760559277239 1556 1084979
SGTC_1120 ficusin 1.78878 µM 0.507838779462318 0.325523453751632 no 1081 0.305783205686375 1585 6199 A DNA cross-linker.
SGTC_3082 9117008 49.47 µM 0.507563360737282 0.32562153814717 no 1082 0.305879795554636 1467 41448529
SGTC_2687 chenodiol 100 µM 0.507388113848612 0.325683954805764 no 1083 0.305941262000239 1511 5702181 A cholesterol synthesis inhibitor.
SGTC_560 2332-1943 155 µM 0.506428959506524 0.326025657729436 no 1084 0.306277774504655 1487 21177716
SGTC_249 wiskostatin 11.211 µM 0.506341929988093 0.326056669611627 no 1085 0.306308316288575 1496 2775510 A n-wasp and actin depolymerizer.
SGTC_2954 9074818 52.69 µM 0.506174819024511 0.326116220889756 no 1086 0.30636696530117 1519 16648742
SGTC_346 4513-0042 7.16 µM 0.505660901760791 0.326299387045944 no 1087 0.306547360015026 1457 2827372
SGTC_1260 0700-1617 7.75 µM 0.505288407806658 0.32643217446652 no 1088 0.306678141771965 1497 2853078
SGTC_444 curcumin 90.4 µM 0.504791457323151 0.326609362660463 no 1089 0.306852658252716 1483 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1142 3253-1408 9.78 µM 0.502260630769571 0.327512337634733 no 1090 0.307742099326489 1478 256655
SGTC_3113 9123498 49.47 µM 0.499284039529197 0.328575649579432 no 1091 0.308789648684053 1523 8897275
SGTC_1799 st045822 46.1415 µM 0.499167551185943 0.328617290404068 no 1092 0.308830676057094 1543 3674992
SGTC_3061 glucosamine 200 µM 0.498849294801082 0.328731067643379 no 1093 0.308942778605165 1495 91431 and experimental redox chemotherapeutic
SGTC_672 1441-0018 53.7 µM 0.497262849746674 0.329298461302327 no 1094 0.309501852938343 1444 251141
SGTC_88 0180-0332 8.668 µM 0.49659124316182 0.329538780655585 no 1095 0.309738664786872 1511 3101745
SGTC_1603 st002045 67.8 µM 0.495339211288873 0.329986980116782 no 1096 0.310180348335883 1495 5887985
SGTC_1590 st077108 57.8 µM 0.494856779307791 0.330159745196077 no 1097 0.310350610669404 1520 5489485
SGTC_561 1550-0330 72.9 µM 0.494818153069227 0.33017357931402 no 1098 0.310364244594906 1456 6812934
SGTC_1502 4534-4282 27.7 µM 0.494760577556666 0.330194200609484 no 1099 0.310384567540182 1492 3278949
SGTC_933 2914-0560 114 µM 0.493642925669954 0.330594601903216 no 1100 0.310779189789144 1636 463887
SGTC_2271 7849410 118.62 µM 0.492240726371537 0.331097217235938 no 1101 0.311274588439791 1505 972430
SGTC_2263 7948595 193.29 µM 0.491857522138862 0.331234628990022 no 1102 0.31141003448673 1477 2971371
SGTC_259 usnic acid 108.925 µM 0.490225629549824 0.331820057467739 no 1103 0.311987123304999 1537 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2014 4013930 200 µM 0.488438494052719 0.332461649514301 no 1104 0.312619640729158 1465 64556
SGTC_1111 tnp00062 510.699 nM 0.487261435103587 0.332884488948733 no 1105 0.313036536741187 1625 676306
SGTC_277 nystatin 15.5 µM 0.487112916886766 0.332937856838373 no 1106 0.313089156590755 1468 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_703 3875-0075 71.8 µM 0.486133899682616 0.333289737258982 no 1107 0.313436116584373 1559 2850814
SGTC_1177 0983-0204 23.6 µM 0.485991128276294 0.333341064728304 no 1108 0.313486728036455 1566 766818
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.484119695026513 0.334014148294028 no 1109 0.314150462283514 1531 66535 A nucleotide analog.
SGTC_3065 9113888 49.47 µM 0.4831336999853 0.33436898836347 no 1110 0.314500403563831 1549 16648368
SGTC_2598 perillyl alcohol 100 µM 0.482342395701413 0.334653870189609 no 1111 0.314781367413362 1553 10819 An apoptosis inducer.
SGTC_1481 3346-2004 36 µM 0.481414794577945 0.334987942210319 no 1112 0.315110861947541 1507 2770522
SGTC_1588 farnesol 29.9 µM 0.475293327088013 0.337195829668165 no 1113 0.317288957320258 1496 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2605 digitonin 300 nM 0.474177369205739 0.337598940520202 no 1114 0.317686715011355 1563 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3166 9102297 49.47 µM 0.471760404067399 0.338472645098136 no 1115 0.318548908276511 1469 25237072
SGTC_1609 st001574 46.4 µM 0.471367893061165 0.338614615486582 no 1116 0.318689019935213 1493 3960012
SGTC_1710 st031758 61.5 µM 0.470837179342257 0.338806609968642 no 1117 0.318878505983491 1600 5394341
SGTC_1296 1068-0102 11.9 µM 0.470640929977152 0.338877617039509 no 1118 0.318948586860313 1572 767053
SGTC_2476 5806916 10.51 µM 0.468907485487896 0.33950506142464 no 1119 0.319567882773205 1563 2870194
SGTC_2745 rifampicin 24.3 µM 0.468488751857543 0.3396566947126 no 1120 0.319717556457828 1626 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1665 st014639 11.4 µM 0.468281573836704 0.339731728342162 no 1121 0.319791621789396 1594 981133 YIL048W NEO1
SGTC_38 0929-0051 58.268 µM 0.467930240571765 0.339858985169093 no 1122 0.319917238480776 1644 1379719
SGTC_2762 leflunomide 42.06 µM 0.466242089938483 0.340470706484063 no 1123 0.320521112464515 1561 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3133 9127736 49.47 µM 0.465939422641318 0.340580425993983 no 1124 0.320629430897262 1609 27243420
SGTC_1837 st055472 66.5 µM 0.465658103684268 0.34068241864469 no 1125 0.320730122894417 1581 676091
SGTC_2462 5162487 171.77 µM 0.46546143084696 0.340753729624827 no 1126 0.320800525490662 1541 2259986
SGTC_1848 st056003 16.4 µM 0.463863522766355 0.341333320820081 no 1127 0.321372764285554 1561 146492
SGTC_1618 st003135 44.5 µM 0.461170457844899 0.342310992748725 no 1128 0.322338157453315 1523 1270615
SGTC_2015 5119600 184 µM 0.460171069424352 0.342674073367478 no 1129 0.322696717510743 1648 2828786
SGTC_770 0389-1121 67.2 µM 0.459452885153967 0.342935081533468 no 1130 0.322954489157454 1646 6753108
SGTC_731 3966-0296 387 µM 0.459371676083447 0.342964599891863 no 1131 0.322983642179848 1537 660956
SGTC_1863 st057641 20.1 µM 0.459263530532692 0.343003910771208 no 1132 0.323022466744195 1541 3921635
SGTC_1363 1636-0063 10.4 µM 0.457398138031695 0.343682247604991 no 1133 0.323692451219998 1553 6072185
SGTC_1312 1218-2183 165 µM 0.453878932925059 0.344963351668205 no 1134 0.324957983695061 1554 6744073
SGTC_2135 5326629 150.42 µM 0.450386446428619 0.34623648881603 no 1135 0.326215908047936 1512 5020077
SGTC_666 0272-0154 136 µM 0.448962156503264 0.346756194022625 no 1136 0.326729478172077 1560 6870312
SGTC_412 gemfibrozil 100 µM 0.446783466928805 0.347551727942382 no 1137 0.327515704848589 1564 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1206 3978-0017 132 µM 0.445614987294725 0.347978667500541 no 1138 0.327937691326563 1647 3873677
SGTC_2121 5257820 149.641 µM 0.444433003432328 0.348410737396368 no 1139 0.328364778346815 1658 791256
SGTC_930 2810-3379 265 µM 0.443848852172116 0.348624344452209 no 1140 0.328575933002435 1710 1015764
SGTC_3128 9127691 49.47 µM 0.441948645775237 0.349319526176419 no 1141 0.329263183935091 1580 41316314
SGTC_2064 5220758 200 µM 0.441663987628099 0.349423710661166 no 1142 0.329366186514418 1591 788518
SGTC_1337 1486-1011 40.3 µM 0.441635861354445 0.349434005454083 no 1143 0.329376364613711 1545 X1337
SGTC_313 3474-0040 5.03 µM 0.440646312702138 0.349796270998685 no 1144 0.329734534578965 1527 1043375 YIL048W NEO1
SGTC_1278 0874-0585 172 µM 0.440147038259201 0.349979103167925 no 1145 0.329915307700521 1593 766306
SGTC_1248 0469-0687 58.6 µM 0.438545563150324 0.350565791072833 no 1146 0.330495424360456 1640 4017482
SGTC_2286 7945697 125 µM 0.438499853122809 0.350582541825776 no 1147 0.330511988301034 1497 1245733
SGTC_2000 st075254 36.4 µM 0.437485693769688 0.350954262150295 no 1148 0.330879574527933 1548 17234175
SGTC_641 4092-0595 30 µM 0.435292733898325 0.351758536263761 no 1149 0.331674979179896 1619 786260
SGTC_565 1418-0001 44.5 µM 0.434952709831293 0.35188330057155 no 1150 0.331798376818088 1635 2862145
SGTC_2321 7390090 138.78 µM 0.434633451810762 0.352000459757549 no 1151 0.331914254894094 1491 649046
SGTC_1058 3448-5425 97.3 µM 0.434319586525854 0.352115653651249 no 1152 0.332028191294951 1536 7279705
SGTC_3233 9132340 49.47 µM 0.434208386512568 0.352156469202424 no 1153 0.332068561796665 1522 17682950
SGTC_2882 9058044 58.44 µM 0.433292977425056 0.352492531382677 no 1154 0.332400969642711 1496 18076804
SGTC_3052 9092717 49.47 µM 0.432799019737604 0.352673919475983 no 1155 0.332580392778022 1563 25237534
SGTC_2575 plumbagin 510 nM 0.43190776487733 0.353001285314081 no 1156 0.332904225514483 1509 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1919 st067113 52.3 µM 0.431266440221527 0.353236916917828 no 1157 0.333137324583315 1560 1268243
SGTC_2831 7999036 19.48 µM 0.43006753588335 0.353677561933209 no 1158 0.333573257232856 1751 2988270
SGTC_2203 7227154 166.4 µM 0.428913854356372 0.354101770957484 no 1159 0.333992958726342 1582 896304
SGTC_478 N-arachidonylglycine 10 µM 0.426452935419502 0.3550072562796 no 1160 0.33488891788334 1590 5283389
SGTC_2931 9014674 55.67 µM 0.42610283931093 0.355136139451718 no 1161 0.335016455678933 1520 2996810
SGTC_1161 k007-0610 110 µM 0.425712396880382 0.355279895129141 no 1162 0.335158713826173 1632 5843850
SGTC_3151 9099821 49.47 µM 0.425181926387304 0.355475240263497 no 1163 0.335352029244947 1542 17174189
SGTC_2428 5615643 7.78 µM 0.424947851960231 0.355561449973335 no 1164 0.335437345117309 1628 2253075
SGTC_2686 alizarin 95.37 µM 0.424469990301143 0.355737469561252 no 1165 0.33561154334661 1526 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2261 9010538 184.68 µM 0.42396906337556 0.355922018230944 no 1166 0.335794187654381 1514 6457250
SGTC_2226 7298446 200 µM 0.423099769034836 0.356242358865383 no 1167 0.336111235444508 1663 3283010
SGTC_2369 9071472 200 µM 0.422198484328796 0.356574595311779 no 1168 0.336440073860558 1641 17296037
SGTC_3327 9140648 26.9345 µM 0.42188176674669 0.356691371322271 no 1169 0.33655565964748 1691 8029710
SGTC_3196 9111891 49.47 µM 0.421454147781846 0.356849058767054 no 1170 0.336711743293727 1567 18891510
SGTC_3273 9137859 49.47 µM 0.420495758499377 0.357202560249176 no 1171 0.337061663632225 1642 2377234
SGTC_1160 4092-0570 10.5 µM 0.420212607311086 0.35730702392087 no 1172 0.337165072801282 1540 4994975
SGTC_1725 st036284 20.55 µM 0.42010455521562 0.357346890668791 no 1173 0.337204537569338 1748 707914
SGTC_477 mead ethanolamide 10 µM 0.419822038734679 0.357451134905805 no 1174 0.33730773188463 1561 16061185
SGTC_3145 9085516 49.47 µM 0.41918526555671 0.357686133413942 no 1175 0.337540369817648 1558 25236195
SGTC_1351 1496-0003 46.5 µM 0.418822990799198 0.357819853502475 no 1176 0.337672750556392 1650 3891978
SGTC_582 0987-0078 156 µM 0.41802477678207 0.358114545719341 no 1177 0.337964501038903 1596 1625765
SGTC_210 3551-0445 56.827 µM 0.416733759488741 0.358591354630606 no 1178 0.338436579153427 1643 2865180 YOR207C RET1
SGTC_3254 9136651 49.47 µM 0.416456313120147 0.358693852170452 no 1179 0.338538064396573 1569 16454030
SGTC_62 0180-0423 3.232 µM 0.415826590087673 0.358926529704719 no 1180 0.338768450057423 1608 30102 YGL099W LSG1
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.415376865869436 0.359092731192633 no 1181 0.338933019661896 1676 688662
SGTC_186 3455-3465 67.277 µM 0.4139951280025 0.3596035373051 no 1182 0.339438837435209 1591 755278
SGTC_3037 9091026 49.47 µM 0.411837076375553 0.360401835798507 no 1183 0.340229421916115 1622 25236398 YIL048W NEO1
SGTC_999 SEC7.066 22.7 µM 0.411542811325121 0.360510736493603 no 1184 0.340337278029152 1657 740511 YDR170C SEC7
SGTC_2622 2-methoxyxanthone 59.94 µM 0.410755426254298 0.360802185136968 no 1185 0.340625940205566 1756 71034 A hepatoprotective.
SGTC_1085 doxorubicin 7.67 µM 0.408166810805168 0.361760923842893 no 1186 0.34157560632229 1725 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2596 sinensetin 100 µM 0.407692137771815 0.361936821637989 no 1187 0.341749855171809 1585 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2276 7947513 42.08 µM 0.407533219130386 0.361995718038493 no 1188 0.341808200529756 1473 2105100
SGTC_1270 0831-1170 17.3 µM 0.405830316078116 0.362627031135822 no 1189 0.342433640958359 1602 6764716
SGTC_101 0490-5701 117.494 µM 0.405778228030927 0.362646347508617 no 1190 0.342452778623975 1706 4661669
SGTC_2114 5491910 81.25 µM 0.405410254750822 0.362782816967681 no 1191 0.342587987179874 1702 2849228
SGTC_750 4073-0104 132 µM 0.404971204604465 0.362945669356308 no 1192 0.342749338698673 1541 22330957
SGTC_77 0828-0286 12.516 µM 0.404526166512528 0.363110768089813 no 1193 0.342912920076304 1536 745345
SGTC_1090 efavirenz 20.7 µM 0.40416218247176 0.363245816577971 no 1194 0.343046730544073 1668 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1211 1056-0033 32.3 µM 0.403015802701516 0.363671267287003 no 1195 0.343468299606635 1691 6741922
SGTC_1273 0849-0096 14.1 µM 0.40219832347359 0.363974757384017 no 1196 0.343769037985329 1606 5286025
SGTC_2638 epoxomicin 18 µM 0.401661736529931 0.36417401230548 no 1197 0.343966494066998 1721 9915668 A protesome inhibitor.
SGTC_2252 omeprazole 400 µM 0.399234008164421 0.365075977382138 no 1198 0.344860393503279 1700 4594 A proton pump inhibitor.
SGTC_852 0418-0143 439 µM 0.399122707282654 0.365117346539366 no 1199 0.344901395754229 1702 5369229
SGTC_479 n-linoleoylglycine 10 µM 0.397670996635987 0.365657072990852 no 1200 0.345436359651813 1621 6433346 An anti-infammatory.
SGTC_1399 3562-5772 25 µM 0.39631877824403 0.366160048942956 no 1201 0.345934937981766 1612 23847490
SGTC_2339 9000433 200 µM 0.395238919912738 0.36656188214748 no 1202 0.346333286029094 1561 2988954
SGTC_447 ml7 120 µM 0.395064470204391 0.366626811517745 no 1203 0.346397654602954 1709 4216 Selective myosin light chain kinase inhibitor.
SGTC_2993 9054257 71.4286 µM 0.393804466888131 0.367095892133964 no 1204 0.346862703133935 1598 6470217 YGL055W OLE1
SGTC_1435 4092-0789 56.7 µM 0.393468208337768 0.367221109802227 no 1205 0.346986850219783 1729 2248285
SGTC_2026 5148700 152 µM 0.393154588805087 0.367337909767435 no 1206 0.347102653756594 1627 79838
SGTC_1804 st050076 49.1 µM 0.392663834461088 0.367520703914089 no 1207 0.34728389270524 1665 3895976
SGTC_2679 rapamycin 1 nM 0.389553671872451 0.368679860829249 no 1208 0.34843330768666 1666 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1507 4075-3230 155 µM 0.388173437438413 0.369194657643207 no 1209 0.348943844430305 1687 659771
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.388132096541013 0.369210080504898 no 1210 0.348959140293972 1776 6728940
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.387918157731536 0.369289897052659 no 1211 0.349038300185674 1612 115019
SGTC_3028 9087778 49.47 µM 0.387642582521902 0.369392717286146 no 1212 0.349140275956173 1570 17217395
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.385947469103815 0.370025388542478 no 1213 0.349767786892892 1690 6708739 YPR165W RHO1
SGTC_501 nsc-95397 161 µM 0.385064139249587 0.370355215444848 no 1214 0.350094948011917 1729 262093
SGTC_1375 2910-0797 186 µM 0.383480736480222 0.370946681342114 no 1215 0.350681675335353 1672 742508
SGTC_927 2425-1185 123 µM 0.382238828320137 0.371410798520909 no 1216 0.351142111820364 1593 730375
SGTC_2272 7805186 180 µM 0.381028379534331 0.371863338920081 no 1217 0.351591095158399 1732 2956062 YPR165W RHO1
SGTC_1074 carmofur 3.8 µM 0.379726579402183 0.372350229726202 no 1218 0.352074193962267 1673 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2467 5474540 200 µM 0.376590638926254 0.373523950479514 no 1219 0.35323892276226 1628 5413519
SGTC_1429 4049-0205 9.46 µM 0.376584327624037 0.373526313863187 no 1220 0.35324126825248 1679 22774478
SGTC_2738 aclarubicin 5.55 µM 0.376488018709705 0.373562379104879 no 1221 0.353277060545967 1713 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1454 4239-0054 42.6 µM 0.376301691791602 0.373632156945477 no 1222 0.353346310859813 1757 1340767
SGTC_3044 9093193 49.47 µM 0.375987068950267 0.373749989916872 no 1223 0.353463254692634 1606 25236277
SGTC_1135 dihydrocapsaicin 536.708 nM 0.375321036883051 0.373999472069006 no 1224 0.353710861314717 1562 107982 A Capsaicinoid.
SGTC_1723 st034307 2.5525 µM 0.375009768475574 0.374116085030637 no 1225 0.353826600876528 1635 867466
SGTC_2484 5809818 12.04 µM 0.37469272743356 0.374234872482995 no 1226 0.353944500777749 1680 2870548
SGTC_2680 butyl paraben 22.24 µM 0.372884611544939 0.374912556803986 no 1227 0.354617162795787 1684 7184 An antifungal and steroid mimetic.
SGTC_1205 4161-2785 76 µM 0.371448783437869 0.375450982530244 no 1228 0.355151648191742 1583 3498106
SGTC_3227 9130768 49.47 µM 0.370504445079293 0.375805235331911 no 1229 0.35550333257792 1704 17720899
SGTC_2298 7976326 193.81 µM 0.370136614673992 0.375943249131975 no 1230 0.355640350918716 1709 2235818
SGTC_2982 9019404 25.97 µM 0.370081789396145 0.375963821506812 no 1231 0.355660775158459 1481 22333232
SGTC_1850 st056238 17 µM 0.367226165924291 0.377035838073726 no 1232 0.356725161570047 1638 5393177
SGTC_130 0136-0219 337.655 µM 0.367000578708108 0.377120565272632 no 1233 0.356809293166975 1791 234244
SGTC_3356 9151811 4.48 µM 0.366233388737889 0.37740875465256 no 1234 0.357095464840966 1654 1859254 YPR165W RHO1
SGTC_3268 9137683 49.47 µM 0.365101509360837 0.377834061614349 no 1235 0.357517817130296 1680 1953228
SGTC_681 1642-0006 26.6 µM 0.363977787418603 0.378256449941144 no 1236 0.357937298226012 1637 4446530
SGTC_671 0560-0003 407 µM 0.362970631202642 0.378635146849895 no 1237 0.358313411624797 1756 3238678
SGTC_3011 9081274 71.4286 µM 0.362601626642926 0.378773924023104 no 1238 0.358451247487302 1669 6625322
SGTC_1546 5-methoxyflavanone 78.7 µM 0.361906076322143 0.379035552730314 no 1239 0.358711109529568 1791 147795
SGTC_2109 5483026 200 µM 0.360938954344433 0.379399424212178 no 1240 0.359072541177053 1706 759335
SGTC_92 0063-0024 660.874 µM 0.360661503275076 0.379503832573894 no 1241 0.359176253158954 1703 3594437
SGTC_1002 4049-0206 172 µM 0.359701741868057 0.379865070713059 no 1242 0.359535094646457 1640 4662749
SGTC_3278 9139605 49.47 µM 0.359215776849852 0.38004801982402 no 1243 0.359716837500966 1771 7958859
SGTC_2783 7738165 71.43 µM 0.358844508844551 0.380187807546422 no 1244 0.359855706957209 1572 17201110
SGTC_2988 9073640 71.4286 µM 0.357810426878942 0.380577236673224 no 1245 0.360242593493897 1717 9102229
SGTC_3313 9133968 57.047 µM 0.353476731843071 0.382210592890237 no 1246 0.361865534826849 1705 1494643
SGTC_2841 9004761 38.96 µM 0.352979525468312 0.382398123157063 no 1247 0.362051895068421 1574 2991039
SGTC_2935 9038016 29.96 µM 0.352385321296101 0.382622274055124 no 1248 0.362274654407688 1803 6463195
SGTC_2283 7944793 200 µM 0.352012051018894 0.382763102452536 no 1249 0.362414612391993 1629 2970533
SGTC_1505 k297-0037 20.6 µM 0.351149807796876 0.383088471089984 no 1250 0.362737981446849 1664 4089396
SGTC_2611 pyromycin 23.93 µM 0.350955099888936 0.383161955806795 no 1251 0.362811016761047 1643 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_690 glyoxal 20.3 µM 0.350618141622307 0.383289137168147 no 1252 0.362937422251865 1690 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.350166343373995 0.383459683413756 no 1253 0.363106931896284 1685 442882
SGTC_3184 9108758 49.47 µM 0.348462344860201 0.384103117171414 no 1254 0.363746494134975 1696 902885
SGTC_2413 inermin 26.06 µM 0.348299258334921 0.384164715801991 no 1255 0.363807725390128 1832 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_887 0885-0007 9.62 µM 0.346591866837335 0.384809781858132 no 1256 0.364448978467397 1770 5719458
SGTC_1946 st076057 65.1 µM 0.346417153745379 0.384875807871472 no 1257 0.364514617723411 1677 953009
SGTC_170 4197-0004 226 µM 0.344603108775337 0.385561552528397 no 1258 0.365196384167304 1776 218692
SGTC_3170 9103054 49.47 µM 0.343847359168964 0.385847346465024 no 1259 0.365480540925903 1678 16432970
SGTC_485 niflumic acid 177 µM 0.342973531830271 0.386177869869464 no 1260 0.365809186167131 1759 4488 A COX2 inhibitor.
SGTC_3068 9116768 49.47 µM 0.340039290485163 0.387288343914197 no 1261 0.366913469735022 1711 41904888
SGTC_1411 3909-8223 150 µM 0.339924359154068 0.387331858926339 no 1262 0.366956745919637 1814 X1411
SGTC_1459 k035-0031 35.7 µM 0.338793433624684 0.3877601225341 no 1263 0.367382674132806 1622 3877128 YMR208W ERG12
SGTC_1685 st024049 53.0905 µM 0.337709420237579 0.388170749465087 no 1264 0.367791087550961 1733 1941139
SGTC_2254 7938975 95.19 µM 0.337476606410957 0.388258956241798 no 1265 0.367878822124808 1803 2969277
SGTC_382 3229-0966 23.2 µM 0.337195035207868 0.388365643552535 no 1266 0.367984939850032 1808 5722370
SGTC_713 1488-1073 324 µM 0.336846573857855 0.388497687197558 no 1267 0.368116280886364 1816 3312542
SGTC_1357 1503-1303 39.5 µM 0.336379445897266 0.388674717798996 no 1268 0.368292373580074 1720 292895
SGTC_793 0488-0545 106 µM 0.336164843850602 0.388756054722864 no 1269 0.368373281147052 1672 292548
SGTC_1812 st052057 4.327 µM 0.332739176814464 0.390055084395681 no 1270 0.369665587078976 1681 3645418
SGTC_1645 Cervolide 78 µM 0.332301969727394 0.39022096418012 no 1271 0.369830626351387 1721 23173 A fragrance.
SGTC_719 2810-4230 27.3 µM 0.331783810363515 0.390417583772691 no 1272 0.370026254970943 1749 721079
SGTC_2198 6589944 200 µM 0.329638601216657 0.391231897743222 no 1273 0.370836525903335 1781 5290268
SGTC_537 1334-0398 209 µM 0.328862653720513 0.391526562390677 no 1274 0.371129751807191 1871 5846986
SGTC_2900 5328528 85.29 µM 0.328716445872896 0.391582091529531 no 1275 0.371185011259326 1679 795359
SGTC_1945 st075991 56.6 µM 0.328239465805664 0.391763261950456 no 1276 0.371365304975373 1690 1084980
SGTC_1677 st019204 53.9 µM 0.324758820667535 0.393086017004867 no 1277 0.372681806465287 1664 3945625
SGTC_2814 7977482 42.97 µM 0.324203314146561 0.393297241731622 no 1278 0.372892056575211 1846 6456762
SGTC_2082 5219693 150 µM 0.323604436118319 0.393524993142141 no 1279 0.373118764507012 1695 2834649
SGTC_782 0083-0095 30.5 µM 0.322737017859096 0.393854934134293 no 1280 0.373447207426262 1730 3591729 An indicator and reagent.
SGTC_257 daunorubicin 18.5 µM 0.322149456759206 0.394078468810482 no 1281 0.373669736302424 1873 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1917 st066507 28.5 µM 0.321194427753116 0.39444187924066 no 1282 0.374031527313048 1714 3156428
SGTC_1664 st014217 9.02 µM 0.321150906264771 0.394458442356329 no 1283 0.374048017085326 1802 3982782
SGTC_2654 protoveratrine a 100 µM 0.321110283965074 0.394473902290433 no 1284 0.374063408597603 1787 5702278 A heart drug and vasodilator.
SGTC_1402 3909-7673 35.9 µM 0.319716116334276 0.395004591740109 no 1285 0.374591770737935 1720 5328014
SGTC_1912 st060209 90.8 µM 0.318574392090087 0.395439333860941 no 1286 0.375024637280624 1678 688787
SGTC_709 3807-1509 243 µM 0.318487970075573 0.395472246665851 no 1287 0.37505740922683 1768 1886677 YPL242C IQG1
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.3183462451351 0.39552622255155 no 1288 0.375111154454688 1818 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1052 3253-3998 198 µM 0.316948175783059 0.39605878392913 no 1289 0.37564146302646 1723 5450317
SGTC_3161 9100388 49.47 µM 0.316471988012851 0.396240220726594 no 1290 0.375822141863101 1801 25236368
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.315620240524321 0.396564809110286 no 1291 0.376145386353901 1922 551469
SGTC_3291 9121177 71.43 µM 0.314377149490807 0.39703866135521 no 1292 0.376617304544535 1728 17015612
SGTC_1242 0402-0103 60.1 µM 0.314198915547856 0.397106614597625 no 1293 0.376684983139529 1742 432868
SGTC_209 4077-0173 175.592 µM 0.313627549043803 0.397324474099801 no 1294 0.376901966693619 1783 15993494
SGTC_174 3553-0389 74.3 µM 0.312718555960781 0.397671135113236 no 1295 0.377247248267402 1799 738071
SGTC_2102 5377816 72.7585 µM 0.31196222413271 0.397959637600615 no 1296 0.377534616200499 1882 1379702
SGTC_2264 7948757 110.76 µM 0.310321796600711 0.398585569637021 no 1297 0.378158128734337 1711 2971411
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.310067062309062 0.398682791134199 no 1298 0.378254979585734 1776 364106
SGTC_1667 st014849 34.6 µM 0.309877695962846 0.398755068476761 no 1299 0.378326982277662 1798 5348460
SGTC_2327 6189656 200 µM 0.309131465671636 0.399039923416162 no 1300 0.378610762239885 1861 5349088
SGTC_733 4069-0007 56.1 µM 0.307928163076209 0.399499367600502 no 1301 0.379068497648806 1803 5717425 YNL287W SEC21
SGTC_264 promethazine 12.5 mM 0.306610498071427 0.40000263723594 no 1302 0.379569930997125 1884 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_704 1310-0270 142 µM 0.306530253036723 0.400033291440007 no 1303 0.379600474550857 1716 5718033
SGTC_2055 5235184 200 µM 0.306350050957565 0.400102132228036 no 1304 0.379669067350336 1781 2836034
SGTC_1865 st057639 52.2 µM 0.306230745553716 0.400147710979764 no 1305 0.379714482293097 1797 688818
SGTC_2849 9019321 12.99 µM 0.305456132527618 0.400443672751718 no 1306 0.380009387780411 1781 16489627
SGTC_3001 9076041 71.4286 µM 0.304445139160952 0.400830035982226 no 1307 0.380394391363456 1762 16004211
SGTC_865 0488-0499 301 µM 0.303120643505824 0.401336354641946 no 1308 0.380898961275067 1912 9634651
SGTC_1067 clotrimazole 1.36 µM 0.301569163244634 0.401929654042982 no 1309 0.381490259154638 1768 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2756 carbadox 75.1 µM 0.30149977092804 0.401956195553783 no 1310 0.381516712327251 1761 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_145 3737-0113 38.366 µM 0.301387535767685 0.401999124760894 no 1311 0.381559498870556 1895 6849351
SGTC_604 1000-0114 314 µM 0.30086645052039 0.402198451904088 no 1312 0.381758167125753 1898 1572745
SGTC_2284 7945075 39.21 µM 0.300609333545803 0.402296814460834 no 1313 0.381856206674883 1926 1245402
SGTC_3301 9125354 19.7965 µM 0.300031189409792 0.402518011615005 no 1314 0.382076682605834 1734 41905162
SGTC_1574 spiramycin 23.7 µM 0.298657871542652 0.403043566158412 no 1315 0.382600552161159 1738 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_322 k048-0136 19.3 µM 0.297422245516986 0.403516577227027 no 1316 0.383072081108619 1820 6823282
SGTC_208 k072-0098 12.366 µM 0.297341889043858 0.403547343454331 no 1317 0.383102752062227 1801 5948901
SGTC_25 0118-0223 35.662 µM 0.295960639959966 0.404076277929352 no 1318 0.383630070129636 1867 5333628
SGTC_3058 9093861 49.47 µM 0.295312583356297 0.404324504753022 no 1319 0.38387755241165 1829 17217477
SGTC_594 1487-1584 10.8 µM 0.294838352579168 0.404506175027868 no 1320 0.384058683455257 1716 5013332
SGTC_723 4182-0001 115 µM 0.294739794000175 0.4045439338389 no 1321 0.38409633079332 1753 744821 YLR208W SEC13
SGTC_989 1501-0895 10.3 µM 0.294109016936103 0.404785612094316 no 1322 0.384337300464718 1924 2830112
SGTC_125 0133-0007 11.75 µM 0.293751209658044 0.404922719850157 no 1323 0.384474010003218 1958 26541
SGTC_2926 9010726 65.15 µM 0.293341263244389 0.405079821087749 no 1324 0.384630658311295 1734 2994293
SGTC_2443 5493264 126.67 µM 0.293054989135483 0.405189537223077 no 1325 0.384740060256188 1883 5340055
SGTC_644 1498-1197 63.3 µM 0.292132345121448 0.405543196312123 no 1326 0.385092718480149 1853 6741615
SGTC_2199 6590217 200 µM 0.291354567898521 0.405841386370477 no 1327 0.385390078757544 1862 703109
SGTC_110 0850-0284 111.64 µM 0.290574620512306 0.406140463312928 no 1328 0.385688336407431 1841 3906265
SGTC_441 propafenone 146 µM 0.289320092394112 0.406621636806262 no 1329 0.386168218988592 1788 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2290 7904846 200 µM 0.288667547836263 0.406871975672468 no 1330 0.386417899503756 1753 2962154
SGTC_1280 0880-0253 10.1 µM 0.287948909827871 0.407147714323714 no 1331 0.386692923511631 1802 6836607
SGTC_279 1273-0055 2.93 µM 0.287897836047796 0.407167312890816 no 1332 0.386712471703367 1922 2847562
SGTC_2962 9082311 13.18 µM 0.28473589648983 0.408381096279503 no 1333 0.387923243535309 1729 16459453
SGTC_2943 9068529 45.32 µM 0.284690977633456 0.408398345781305 no 1334 0.387940451774063 1841 3270634
SGTC_207 4185-0010 4.486 µM 0.284032802371379 0.408651115103038 no 1335 0.388192621369663 1917 3761753
SGTC_270 tamoxifen 5.46 µM 0.283557995342843 0.408833486262332 no 1336 0.388374565562944 1937 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1494 4358-1428 177 µM 0.283051010318578 0.409028238630523 no 1337 0.388568867281557 1955 1564571
SGTC_317 4495-0002 170 µM 0.282010448449365 0.409428028609069 no 1338 0.388967749317482 1773 15991618
SGTC_445 e6 berbamine 66 µM 0.28117435384234 0.409749329347404 no 1339 0.389288337081244 1799 6610268 A calcium/calmodulin antagonist.
SGTC_305 1682-2595 20.8 µM 0.281054404066494 0.409795429528409 no 1340 0.389334336186243 1845 226033
SGTC_223 busulfan 5 mM 0.279837388436978 0.410263234370382 no 1341 0.389801132682794 1884 2478 A DNA alkylator.
SGTC_2279 7948423 32.93 µM 0.278478143019716 0.410785861438862 no 1342 0.390322670532963 1970 1247112
SGTC_2220 6782180 200 µM 0.277340104964429 0.411223556623246 no 1343 0.390759483771085 1916 833803
SGTC_3008 9078912 71.4286 µM 0.276884149819916 0.411398950318762 no 1344 0.390934531790091 1802 16648731
SGTC_3117 9124945 49.47 µM 0.276561194080361 0.411523193432119 no 1345 0.391058532715529 1723 17592065
SGTC_1214 0358-0031 63.7 µM 0.276315547881813 0.411617701018204 no 1346 0.391152857564191 1976 4301366
SGTC_1382 3002-2117 298 µM 0.275206216831503 0.412044558304024 no 1347 0.391578905490305 1932 1497314
SGTC_1460 k062-0059 9.15 µM 0.274409520859749 0.412351181609934 no 1348 0.39188496357407 1741 1373085
SGTC_2955 9076254 12.21 µM 0.272320747924631 0.413155338409936 no 1349 0.392687702156981 1956 16459619
SGTC_2225 6654152 15.4 µM 0.271639929198579 0.413417525775987 no 1350 0.392949447191555 1886 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2953 9074162 66.49 µM 0.271609596339447 0.413429208040931 no 1351 0.392961109977049 1995 16451992
SGTC_2316 5844804 197.44 µM 0.271348990040273 0.413529579970007 no 1352 0.393061315348757 1953 776813
SGTC_2125 5246583 200 µM 0.271204750339085 0.413585135995699 no 1353 0.393116779805863 1988 835267
SGTC_2502 avocadyne acetate 18.59 µM 0.270845060546029 0.413723683301703 no 1354 0.393255100683475 1795 3952079
SGTC_2194 5927483 104.545 µM 0.268260034185225 0.414719713041906 no 1355 0.394249583585082 1877 760979
SGTC_2698 st077697 67.5 µM 0.26574764781072 0.415688279786243 no 1356 0.395216782351859 1748 3154499
SGTC_1976 st070609 63.5 µM 0.264915851240136 0.416009064404869 no 1357 0.395537143477062 1872 682556
SGTC_925 2064-1272 59.6 µM 0.263531013034081 0.416543255092422 no 1358 0.396070661565016 1788 6815817
SGTC_3114 9122766 49.47 µM 0.263121546762286 0.416701233132864 no 1359 0.39622844850328 1785 17176985
SGTC_1234 0326-0494 15.5 µM 0.262140358971893 0.417079844346142 no 1360 0.396606616218966 1927 1547813
SGTC_1786 berberine 21.6 µM 0.261494468861443 0.417329116147792 no 1361 0.396855607194542 1786 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3121 9125696 49.47 µM 0.259679711213951 0.418029672747269 no 1362 0.397555421997876 2003 1235365
SGTC_502 l-744,832 89.3 µM 0.258571798414302 0.418457491852338 no 1363 0.397982822494228 1965 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2073 5212005 126 µM 0.258557203433747 0.418463128330282 no 1364 0.397988453631017 1998 691789
SGTC_831 k061-1017 217 µM 0.258531951614363 0.418472880443315 no 1365 0.397998196513586 1945 1240153
SGTC_2899 9053889 58.44 µM 0.257542406445651 0.418855076716117 no 1366 0.398380041697156 1987 6470052
SGTC_1022 4477-0945 21.3 µM 0.257317105350732 0.418942106442398 no 1367 0.398466994383228 1790 4648966
SGTC_2020 4017018 200 µM 0.255566556758169 0.419618446441809 no 1368 0.399142772397194 1828 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3340 9146634 11.102 µM 0.255115448056813 0.419792774866629 no 1369 0.399316966511793 1836 4907387
SGTC_1757 st041620 31.8375 µM 0.254370174454992 0.420080816133771 no 1370 0.39960479532273 1825 5289815
SGTC_2023 5144124 124 µM 0.253939402008171 0.420247325184366 no 1371 0.399771186934394 1843 2830192
SGTC_1128 3448-9350 235 µM 0.253261333967855 0.420509451787115 no 1372 0.400033136637617 1805 619386
SGTC_11 0438-0307 1.3 µM 0.252683646397105 0.420732801264002 no 1373 0.400256343081578 1992 4011476
SGTC_3130 9127414 49.47 µM 0.252212380833468 0.420915024048239 no 1374 0.400438454415126 1939 1494646
SGTC_1073 triclabendazole 3.09 µM 0.251637050276599 0.421137508285561 no 1375 0.400660808965097 1866 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2822 7994718 71.43 µM 0.251569980126855 0.421163446408895 no 1376 0.400686732425998 1904 1018011
SGTC_633 0437-0093 97.7 µM 0.251140387017818 0.42132959160202 no 1377 0.400852785962944 1855 2831118
SGTC_2683 piperine 63.03 µM 0.250833852207093 0.42144815254758 no 1378 0.400971283896243 1874 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1096 rimcazole 32.2 µM 0.250572806215131 0.421549125030773 no 1379 0.401072204286495 1851 18528119 A dopamine reuptake inhibitor.
SGTC_1362 1611-0397 101 µM 0.249784747199115 0.421853977203843 no 1380 0.401376907951102 1838 27816
SGTC_3057 9095946 49.47 µM 0.249736655097505 0.421872582635356 no 1381 0.401395504745446 1894 24540043
SGTC_250 brefeldin a 552.239 µM 0.248669697575487 0.42228540216045 no 1382 0.401808145244108 1877 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_738 1315-0003 72.4 µM 0.248557309379865 0.422328891570957 no 1383 0.401851617200086 1956 6251474
SGTC_1300 1094-0077 113 µM 0.248424975404792 0.422380100356384 no 1384 0.401902805776161 1833 5532636
SGTC_2495 cafestol 54.53 µM 0.247612099758476 0.422694684568152 no 1385 0.402217273984527 1911 16667697 An anti-infammatory.
SGTC_138 0850-0259 40.9225 µM 0.24747675945214 0.422747066282923 no 1386 0.402269637743951 1956 6813004
SGTC_2386 9075165 157.42 µM 0.24669954636148 0.423047902974271 no 1387 0.402570378833275 1895 16452277
SGTC_2986 9022445 71.43 µM 0.24668048845513 0.423055280302604 no 1388 0.402577753978042 1991 6459286
SGTC_1070 indatraline 8.81 µM 0.245367429668532 0.423563631070962 no 1389 0.403085972822567 1825 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1328 1441-0025 69.2 µM 0.244556104956013 0.423877799128614 no 1390 0.403400077615795 1783 4562601
SGTC_2728 chlorpromazine 9.18 µM 0.243246456741587 0.424385034266117 no 1391 0.403907240044106 1914 2726 A thorazine and dopamine antagonist.
SGTC_1061 3448-9325 110 µM 0.242786404707063 0.42456324513682 no 1392 0.404085433994725 1999 723482
SGTC_1801 st050089 28.441 µM 0.242554916604609 0.424652922776305 no 1393 0.404175104815557 1889 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2471 5466956 24.79 µM 0.24202869507226 0.424856793565241 no 1394 0.404378964326465 1916 724419
SGTC_2699 st077704 54.6 µM 0.241583265871322 0.425029379186066 no 1395 0.404551544983938 1882 645852
SGTC_280 3448-3607 3.04 µM 0.239873471402099 0.425691987865018 no 1396 0.405214173633581 2005 626179
SGTC_2818 7996756 12.99 µM 0.239833334998827 0.425707544736421 no 1397 0.405229731717566 1855 2241621
SGTC_422 cantharidin 155 µM 0.239477870022869 0.425845328019097 no 1398 0.40536752722856 1783 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1615 st002656 86.5 µM 0.23879743546558 0.426109099375876 no 1399 0.405631329457347 1871 1584458
SGTC_2730 imipramine 71.33 µM 0.237901341129963 0.426456521952634 no 1400 0.405978807651538 1990 3696 A tricyclic antidepressant.
SGTC_3040 9091894 49.47 µM 0.237628267214989 0.426562406141606 no 1401 0.406084712170342 1960 25236966
SGTC_171 k064-0041 9.68 µM 0.237052565366827 0.426785651399149 no 1402 0.406308005462573 1818 53325
SGTC_2449 5812982 45.77 µM 0.236512291719085 0.426995179670055 no 1403 0.40651758519731 1921 776185
SGTC_1984 st072354 53.1 µM 0.236002554981879 0.427192884040401 no 1404 0.406715343790875 1911 5762938
SGTC_2280 7785178 200 µM 0.234965457198879 0.427595184876993 no 1405 0.407117771937735 1881 2954328
SGTC_2524 avocatin b 10.57 µM 0.234939393059745 0.427605296394771 no 1406 0.407127886948508 1994 6710748
SGTC_2701 st077767 14.721 µM 0.234610842005843 0.427732761032179 no 1407 0.407255396850685 1871 5721188
SGTC_2152 5568786 200 µM 0.234287627944404 0.427858162490456 no 1408 0.407380845069384 1908 5399883
SGTC_3046 9092212 49.47 µM 0.232289652894055 0.428633503487158 no 1409 0.408156524233559 1906 25236637
SGTC_2830 7992007 71.43 µM 0.231651701501388 0.428881127249773 no 1410 0.408404273781019 1818 1952075
SGTC_1996 st072960 66.8 µM 0.231423314058652 0.428969783694731 no 1411 0.408492977352479 2021 1719405
SGTC_3042 9091578 49.47 µM 0.230279819373657 0.429413724307842 no 1412 0.408937170532402 1993 25236497
SGTC_3297 9117502 71.43 µM 0.229943148173786 0.429544447698697 no 1413 0.409067973562008 2006 7453720
SGTC_2088 5278280 127.392 µM 0.229546773018749 0.429698362966349 no 1414 0.409221985668227 1920 791502
SGTC_1698 5-fluorocytosine 1.055 µM 0.228462883662714 0.430119299341809 no 1415 0.409643203839676 2027 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2875 9039966 71.43 µM 0.22744160895871 0.430515991552644 no 1416 0.410040184334536 1998 6463691
SGTC_1973 st070275 50.2 µM 0.227328781695075 0.430559821187575 no 1417 0.410084047173183 2018 17118334
SGTC_105 0111-0055 734.78 µM 0.2272646659077 0.43058472841722 no 1418 0.410108973391471 1923 5179370
SGTC_189 3970-0742 2.116 µM 0.226732485218923 0.430791476707691 no 1419 0.410315882653853 2018 2891807
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.225921074515669 0.431106740300799 no 1420 0.410631403223522 1945 5393153
SGTC_2163 5671233 125 µM 0.225760284206956 0.431169218604598 no 1421 0.410693934105432 2003 701023
SGTC_2534 helenine 20.12 µM 0.225387394500073 0.431314119015777 no 1422 0.410838958558016 1870 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1552 6-methylflavone 10.6 µM 0.223853411428456 0.431910303234424 no 1423 0.411435684027427 2025 689013
SGTC_840 0245-0196 390 µM 0.223443135720788 0.432069783688405 no 1424 0.411595317689245 1993 3827528
SGTC_976 1348-1067 47.6 µM 0.223287861588409 0.43213014401189 no 1425 0.411655736926005 1909 5310671 YGL099W LSG1
SGTC_1961 st076550 68.7 µM 0.218972416648709 0.433808332813401 no 1426 0.413335767334306 1923 1579337
SGTC_3173 9105693 49.47 µM 0.21836981921916 0.434042766387277 no 1427 0.413570489439794 1974 17096658
SGTC_1400 3771-8998 51.5 µM 0.217702314252414 0.434302478570102 no 1428 0.41383053020734 1962 670767
SGTC_2645 abamectin 100 µM 0.216459903262131 0.434785950057876 no 1429 0.414314638399582 2002 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3344 9148862 3.898 µM 0.21621864173284 0.434879845837252 no 1430 0.414408661608291 2003 4905352
SGTC_1049 3226-0134 66 µM 0.214956751759383 0.435371016358826 no 1431 0.41490051871022 2006 5702385
SGTC_3220 9131269 49.47 µM 0.21479308022488 0.435434730212337 no 1432 0.414964324085066 1978 17722206
SGTC_2991 9074669 71.4286 µM 0.213638103955627 0.435884385506155 no 1433 0.415414641333306 1990 17333109
SGTC_2581 avocatin a 64 µM 0.212638920091928 0.436273454606491 no 1434 0.415804305876719 1920 6710728 A skin care supplement.
SGTC_2032 5185112 25.99 µM 0.212523059357405 0.436318573255046 no 1435 0.415849494937213 2001 5718189
SGTC_2774 tamoxifen 10.92 µM 0.212381302553831 0.436373777513921 no 1436 0.415904785732261 1978 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2512 diallyl trisulfide 49.23 µM 0.207923086124485 0.438110564735973 no 1437 0.417644511481003 2044 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2810 7959871 45.46 µM 0.207201782447814 0.438391675965203 no 1438 0.417926137664399 1980 2974535
SGTC_2888 9058547 12.99 µM 0.206116058536422 0.438814870022729 no 1439 0.418350127595693 1913 16476514
SGTC_1250 0485-0349 40.2 µM 0.206051528740029 0.438840024689151 no 1440 0.418375330349796 1923 6842794 YDL195W SEC31
SGTC_438 sphingosine 6.67 µM 0.204910553562125 0.439284834348608 no 1441 0.418821004812227 1770 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_545 4218-0007 221 µM 0.20464418298546 0.439388690091597 no 1442 0.418925066415537 1950 2840508
SGTC_307 1501-1223 22.3 µM 0.204460689960157 0.439460234971922 no 1443 0.418996753978511 1970 2830329
SGTC_1134 3477-0009 42.5 µM 0.204452013101652 0.439463618172948 no 1444 0.419000143944222 2087 3973534
SGTC_843 0310-0051 143 µM 0.20318821261574 0.439956434754736 no 1445 0.419493962820444 1960 2065037
SGTC_263 alizarin 107.927 µM 0.203110482714882 0.439986748425988 no 1446 0.419524339240324 1969 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_980 1473-0395 201 µM 0.203010106911648 0.440025894231176 no 1447 0.419563566264413 1901 768876
SGTC_2345 9052315 157.45 µM 0.202351400558595 0.440282799264765 no 1448 0.419821009575804 1922 6469265
SGTC_1037 k284-1091 78.7 µM 0.202243956096341 0.440324706551552 no 1449 0.419863005533775 1901 3334711
SGTC_1591 genipin 88.4 µM 0.201078165867451 0.440779450438481 no 1450 0.42031872721037 2035 442424 A DNA cross-linking agent.
SGTC_3285 9112818 20.8695 µM 0.200016384432075 0.44119369122992 no 1451 0.420733883558937 1995 17017947 YPR165W RHO1
SGTC_1309 pyrazolanthrone 13.4 µM 0.199322106078071 0.441464590095514 no 1452 0.421005393976847 2054 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_7 0192-1582 4.227 µM 0.198452700413792 0.441803860086093 no 1453 0.421345444148584 1982 252616
SGTC_530 4358-1714 28 µM 0.198424658919764 0.441814803489086 no 1454 0.421356412981223 1999 1564641
SGTC_58 0957-0393 9 µM 0.197957718722266 0.441997036917919 no 1455 0.421539072300973 1928 6997992
SGTC_324 1315-0088 19.6 µM 0.197153930534163 0.442310761235069 no 1456 0.421853540537983 2002 6787421
SGTC_2181 6316240 54.2555 µM 0.19669040377685 0.442491695528172 no 1457 0.422034910040445 1901 12779990
SGTC_2735 sertaconazole 140 nM 0.196342278139613 0.442627591724681 no 1458 0.422171136080731 2082 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3034 9090421 49.47 µM 0.195450220323863 0.442975850987278 no 1459 0.422520252243357 2056 17173761
SGTC_139 0099-0334 718.624 µM 0.194543701162974 0.443329801093869 no 1460 0.422875090366275 2109 97690
SGTC_2903 5923464 63.88 µM 0.193153982443946 0.443872504015949 no 1461 0.423419188350038 2092 2876576
SGTC_1948 st076329 66.6 µM 0.192528224737526 0.444116904832458 no 1462 0.42366423065065 2074 24208413
SGTC_1154 4088-0362 150 µM 0.189383495304703 0.445345454833275 no 1463 0.424896129618434 2048 6618304
SGTC_349 k015-0014 24 µM 0.188941731124218 0.445518080973758 no 1464 0.425069242940902 1908 2196908
SGTC_1629 st005085 44.9 µM 0.18797608862522 0.445895456540211 no 1465 0.425447697772632 1915 24207091
SGTC_2587 piperic acid 92.2 µM 0.186112277726998 0.446623976942443 no 1466 0.42617835694645 1932 5370536
SGTC_1857 st056007 79.3 µM 0.185454574044849 0.446881101176764 no 1467 0.426436253411865 2080 619834
SGTC_1836 st055642 81 µM 0.185258725883704 0.446957670840224 no 1468 0.426513054790608 1882 8571
SGTC_848 0368-0089 85.6 µM 0.184752709511203 0.447155514387061 no 1469 0.426711500771036 2080 762535
SGTC_2012 4023501 200 µM 0.184664778472284 0.447189895227129 no 1470 0.426745986847611 1948 3477460
SGTC_665 3914-0008 307 µM 0.184183327810448 0.447378148390393 no 1471 0.426934819106172 1954 1069549
SGTC_1326 1431-2094 10.8 µM 0.183521389628148 0.447636993753191 no 1472 0.427194468640185 1907 616278
SGTC_1972 st070201 17.4 µM 0.182882484278367 0.447886853472803 no 1473 0.42744511331463 2097 2829099
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.182160531779552 0.448169215711618 no 1474 0.427728372900272 2054 23847180
SGTC_44 0929-0055 61.211 µM 0.181582438012966 0.448395332422695 no 1475 0.427955216074494 1967 1379590
SGTC_2049 5262831 67.185 µM 0.181509193704688 0.448423982540956 no 1476 0.427983958738427 1972 763417
SGTC_2133 5320837 200 µM 0.179621414072532 0.449162495582104 no 1477 0.428724896054705 2053 2841355
SGTC_55 0767-0285 6.563 µM 0.178868767728269 0.449456985533447 no 1478 0.429020373497374 2099 3116166
SGTC_230 MPP+ 141.667 µM 0.178688813786476 0.449527400724543 no 1479 0.429091026561358 1947 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1703 st026983 48.3 µM 0.177564787365245 0.449967263234017 no 1480 0.429532390315109 2106 1104023
SGTC_224 benfluorex 43.875 µM 0.176856740502503 0.45024437307373 no 1481 0.429810459486572 2079 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1189 1431-2119 7.28 µM 0.174568162860755 0.451140223932753 no 1482 0.430709483377298 2060 3107275
SGTC_1476 4112-3294 3.34 µM 0.174428451776393 0.451194921159803 no 1483 0.430764377881809 2066 704369
SGTC_3228 9131799 49.47 µM 0.174147697351106 0.451304839996738 no 1484 0.430874694397906 2017 17015818
SGTC_2492 derrusnin 100 µM 0.173894257342435 0.451404068107927 no 1485 0.430974282923868 1996 1715307 Part of coumarin class of compounds.
SGTC_326 k292-0812 17.5 µM 0.17382861098555 0.451429770796237 no 1486 0.431000079187828 2109 3579357
SGTC_1881 5652484 16 µM 0.173045653487197 0.451736339842466 no 1487 0.431307771296738 2113 2255129
SGTC_658 3253-0951 102 µM 0.172898857380362 0.451793821449895 no 1488 0.431365464903209 2018 1184878
SGTC_2871 9038510 12.99 µM 0.172418452604978 0.451981942753505 no 1489 0.431554283166485 2129 4945164
SGTC_1630 st005209 31.3 µM 0.171518061711262 0.452334555077815 no 1490 0.431908214842416 2154 3367314
SGTC_835 0312-0010 67.2 µM 0.169926202950542 0.452958052828312 no 1491 0.432534086910032 1981 1626196
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.169915080835741 0.45296240953768 no 1492 0.432538460396042 2065 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1443 4112-3303 14 µM 0.169768278059029 0.453019915051971 no 1493 0.43259618759215 2012 704433
SGTC_1862 st057513 3.81 µM 0.169590566729531 0.453089529368102 no 1494 0.432666070870752 2012 5393163
SGTC_1327 1436-0082 2.18 µM 0.167980163506405 0.453720433169996 no 1495 0.433299442275756 1989 15992205
SGTC_1892 st058411 7.36 µM 0.166687618221018 0.454226895109879 no 1496 0.433807924229893 2107 3934738
SGTC_1347 1493-0251 600 nM 0.16642515725579 0.454329745104317 no 1497 0.433911188694589 2102 3986378
SGTC_2087 5276107 200 µM 0.165381212756868 0.454738863558886 no 1498 0.434321970051373 2073 144405
SGTC_1826 st055655 41.6 µM 0.165030625151132 0.45487626849347 no 1499 0.434459938577039 1987 676168
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.163732930839562 0.455384917472086 no 1500 0.434970696157965 2068 6312947
SGTC_2350 9023895 38.85 µM 0.162937025303232 0.455696919740407 no 1501 0.435284009188842 2055 2997209
SGTC_1133 3473-0247 50 µM 0.162586458749634 0.45583435372352 no 1502 0.435422024736059 1878 711311
SGTC_402 epigallocatechin gallate 10 µM 0.16257131218126 0.455840291811437 no 1503 0.435427988009206 1973 65064 An antioxidant.
SGTC_3330 9141424 71.43 µM 0.162315799279432 0.455940465034895 no 1504 0.435528586817791 2115 27261020
SGTC_694 1315-0438 43.2 µM 0.161458987324311 0.456276396524084 no 1505 0.43586595543265 2053 6793154
SGTC_1201 1889-3372 45.9 µM 0.161216763008272 0.456371371435636 no 1506 0.435961339421446 2008 5392199
SGTC_381 3461-2219 42.7 µM 0.161115363295227 0.45641113048332 no 1507 0.436001270082555 2097 2883159
SGTC_1105 epirubicin 18.1 µM 0.161084074264565 0.456423399068319 no 1508 0.436013591666109 1972 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_966 1300-0360 30.2 µM 0.157721291508537 0.457742202717077 no 1509 0.437338211144851 1997 70588
SGTC_3043 9092303 49.47 µM 0.157588287052776 0.457794373573846 no 1510 0.437390616908543 1988 25236084
SGTC_1766 st045414 44.774 µM 0.157295082915597 0.457909385153137 no 1511 0.437506147643902 2090 253960
SGTC_3158 9100007 49.47 µM 0.157127366608546 0.457975174750553 no 1512 0.437572235015892 1981 19297233
SGTC_3142 9086498 49.47 µM 0.156927633930074 0.458053524820617 no 1513 0.437650940474452 2150 25236367
SGTC_2803 7707263 71.43 µM 0.156102214015528 0.458377333396428 no 1514 0.437976226613416 2004 2199229
SGTC_2016 5121758 140 µM 0.155041420862909 0.458793518383809 no 1515 0.438394331485137 2131 2795203
SGTC_1223 0764-0573 147 µM 0.154634407836898 0.458953215358385 no 1516 0.43855477135986 2073 1609797
SGTC_2210 7115885 190.385 µM 0.153862037658386 0.459256283263351 no 1517 0.438859258583068 2057 2927039
SGTC_2127 5253358 187.912 µM 0.153479752498744 0.459406295706401 no 1518 0.439009978145884 2023 20612
SGTC_3181 9108277 49.47 µM 0.153472870631064 0.459408996271746 no 1519 0.439012691468816 2035 17097298
SGTC_3333 9141820 12.094 µM 0.15256610821062 0.459764842052745 no 1520 0.439370226886294 2013 1939433
SGTC_1500 4488-1866 171 µM 0.152413432262418 0.459824760695958 no 1521 0.439430431716828 2134 2900003
SGTC_1320 1313-0481 95.3 µM 0.151193430191484 0.460303590902625 no 1522 0.439911566334108 2122 6813365 YLR208W SEC13
SGTC_942 3253-1115 227 µM 0.151136735223672 0.460325844125149 no 1523 0.439933927403678 2120 46497897
SGTC_2966 9084041 48.03 µM 0.151014148987983 0.460373960615316 no 1524 0.439982277311658 1856 17741380
SGTC_1690 st023502 41.2 µM 0.150947876795372 0.460399973445498 no 1525 0.440008416462563 2142 24207482
SGTC_192 3455-0609 60.9 µM 0.149797410735733 0.46085157555151 no 1526 0.440462226120919 2075 3769639
SGTC_1108 betulinic acid 729.144 nM 0.149313103301696 0.461041699952686 no 1527 0.440653288118329 2027 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1740 st038286 13.222 µM 0.149091463077145 0.461128712151522 no 1528 0.440740731040396 2093 716786
SGTC_514 4466-0038 2.65 nM 0.14783782972609 0.461620902285702 no 1529 0.441235376776671 2035 5722064
SGTC_351 caspofungin 25 nM 0.147128617611988 0.461899372784978 no 1530 0.441515251042324 2067 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_481 bay k-8644 50 µM 0.147093086307801 0.46191332456201 no 1531 0.441529273424521 2007 2303 A calcium channel antagonist.
SGTC_1899 st063254 59.6 µM 0.147063968070582 0.461924758209157 no 1532 0.441540764952962 1969 3093813
SGTC_1678 st019265 80.2 µM 0.145921769632563 0.462373281721521 no 1533 0.44199157292761 2161 5367020
SGTC_3148 9097893 49.47 µM 0.145809208922992 0.462417485155904 no 1534 0.442036002967401 2016 17174100
SGTC_1694 st024011 44.9 µM 0.145505663063752 0.462536692202202 no 1535 0.442155822428502 2140 2787533
SGTC_875 0709-0210 25.7 µM 0.144675598006058 0.46286268844485 no 1536 0.442483503198954 2194 6251364
SGTC_1229 0139-0193 12.2 µM 0.1440754745596 0.463098393939607 no 1537 0.442720435554915 2171 3090752
SGTC_2998 9066762 71.4286 µM 0.14289366482808 0.463562601319997 no 1538 0.443187080981901 2114 4945196
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.142829512605393 0.463587801332331 no 1539 0.443212414174305 2162 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_283 0987-0079 11.7 µM 0.142651937727562 0.463657556327287 no 1540 0.443282538263475 2131 411556
SGTC_1016 4226-1401 38 µM 0.142557578335383 0.463694623055154 no 1541 0.443319801388071 2152 2901613
SGTC_1238 0333-0287 48.8 µM 0.141845199071291 0.463974473585439 no 1542 0.443601140648191 2073 7226
SGTC_754 3474-0146 171 µM 0.141506924009958 0.464107367554507 no 1543 0.443734745257907 1946 24762078
SGTC_1387 3342-1166 1.8 µM 0.141314176699153 0.464183091615339 no 1544 0.443810875307293 2060 3418228
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.140933498129608 0.464332651478035 no 1545 0.443961239283316 1999 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_675 1309-0189 238 µM 0.14071421549299 0.464418804876293 no 1546 0.444047857249989 2029 4246530
SGTC_556 4058-0063 51.5 µM 0.140588346098686 0.464468258136871 no 1547 0.444097577629072 2048 6615692
SGTC_1776 st049249 45.9 µM 0.137594820247503 0.465644554897269 no 1548 0.44528032471711 2006 1822314
SGTC_813 k007-0158 173 µM 0.137261015936932 0.465775741066938 no 1549 0.445412241747945 2138 6523916
SGTC_3290 9121031 71.43 µM 0.13545978598735 0.466483694062236 no 1550 0.446124178638419 2044 17014854
SGTC_2417 cerulenin 830 nM 0.135066496952632 0.466638286039642 no 1551 0.44627964948008 2198 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1898 st060199 18.6 µM 0.134618498593911 0.466814389000128 no 1552 0.446456757491031 2103 688866
SGTC_727 3032-0951 202 µM 0.13361533859301 0.467208743074655 no 1553 0.446853377255363 2085 3652836
SGTC_1943 st076331 65.2 µM 0.133577387227276 0.467223662840241 no 1554 0.446868383147957 2196 24208415
SGTC_2685 mycophenolic acid 18.85 µM 0.132685067940851 0.467574472257097 no 1555 0.447221226249044 2148 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_362 0310-0100 9.03 µM 0.13257379459204 0.467618220408855 no 1556 0.447265229167455 2069 790235
SGTC_3149 9097855 49.47 µM 0.132440525674711 0.467670616837593 no 1557 0.447317931062499 2159 25236625 YMR079W SEC14
SGTC_1841 st054148 70 µM 0.131715395695151 0.467955721024105 no 1558 0.447604703807364 2047 675442
SGTC_1306 1185-0270 9.02 µM 0.131057091621583 0.468214565062697 no 1559 0.44786507212087 2143 1548076
SGTC_2584 androsterone 48.74 µM 0.130965692524878 0.468250504096479 no 1560 0.447901223498968 2187 2754130 A steroid.
SGTC_120 rhodamine 6G 52.259 µM 0.130935736074375 0.468262283327048 no 1561 0.447913072364166 2192 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1010 4112-3296 15.2 µM 0.130534845629979 0.468419920860206 no 1562 0.448071643577208 2195 704384
SGTC_1611 st001856 99.4 µM 0.13039534196841 0.468474777441239 no 1563 0.448126825849324 2007 647478
SGTC_1373 2887-0003 58.5 µM 0.129863744586552 0.468683821265942 no 1564 0.448337114477722 2082 776948
SGTC_1114 scopoletin 1.73284 µM 0.129683256830376 0.468754797718097 no 1565 0.448408514903126 2184 5280460 A coumarin with genotoxic properties.
SGTC_1194 1488-0194 225 µM 0.12937400319022 0.468876413406022 no 1566 0.448530858617203 2069 1391452
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.129282515709982 0.468912391915916 no 1567 0.448567052882969 2213 16623 A steroid.
SGTC_1506 4226-2149 212 µM 0.12611346825934 0.470158811163298 no 1568 0.449821053232025 2090 991114
SGTC_2773 thioridazine 9.09 µM 0.126076986459168 0.470173161559923 no 1569 0.449835492117891 2213 5452 An antipsychotic.
SGTC_177 1327-0068 8.361 µM 0.12539331059506 0.470442097863167 no 1570 0.450106091844727 2195 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_414 piperonyl butoxide 100 µM 0.124876708132637 0.470645321762512 no 1571 0.450310579113429 2052 5794 A potent inhibitor of cytochrome P450.
SGTC_299 1273-0059 1.44 µM 0.124492724507758 0.470796380295076 no 1572 0.45046258028517 2190 2848077
SGTC_1695 st026914 34.495 µM 0.124357314528677 0.47084965136362 no 1573 0.450516184501712 2062 3289191
SGTC_584 0986-0246 15.4 µM 0.12407440949128 0.470960949522966 no 1574 0.450628179919489 2204 53315 YDR232W HEM1
SGTC_2426 5582046 32.21 µM 0.123699134623564 0.471108590555316 no 1575 0.45077674843458 2156 2251934
SGTC_2214 7179297 48.276 µM 0.122872198826205 0.47143393849187 no 1576 0.451104150449674 2127 769744
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.122854888542 0.471440749219323 no 1577 0.451111004327027 2206 229346 A bile salt which induces apoptosis.
SGTC_1388 3346-4487 254 µM 0.122294907838481 0.471661077996169 no 1578 0.451332732342722 2124 3345614
SGTC_2806 7952793 58.44 µM 0.121612156759531 0.471929723462553 no 1579 0.451603092627157 2118 2972490
SGTC_3182 9108849 49.47 µM 0.120132408004329 0.472512011246091 no 1580 0.452189130205811 2104 17133045
SGTC_1683 st010134 710 nM 0.119911476720569 0.472598953769778 no 1581 0.452276636484867 2113 3818134
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.119438591841721 0.472785051330545 no 1582 0.45246394412031 2118 2724278 An inhibitor of dopamine biosynthesis.
SGTC_652 0437-0092 114 µM 0.119068498719345 0.472930700707398 no 1583 0.452610543771952 2159 3091274
SGTC_1463 k081-0032 34.1 µM 0.119058653841166 0.472934575188189 no 1584 0.452614443569876 2138 977755
SGTC_1398 3558-0053 112 µM 0.117571623177377 0.473519829678148 no 1585 0.453203545195154 2102 4532369
SGTC_1942 st076330 65.2 µM 0.117205411734236 0.473663969280121 no 1586 0.453348639267862 2145 24208414
SGTC_1825 st052143 62.6 µM 0.116905266640229 0.473782107959458 no 1587 0.45346756229955 2193 674173
SGTC_286 k060-0067 22.9 µM 0.116506074693019 0.473939235569369 no 1588 0.453625735988338 2128 5985051
SGTC_468 gf-109203x 121 µM 0.115213539819669 0.474448023311799 no 1589 0.454137933460238 2200 2396 A protein kinase C inhibitor.
SGTC_1348 1493-0373 93.8 µM 0.114107765010646 0.474883328755178 no 1590 0.454576183422103 2150 3010129
SGTC_1249 0481-0015 10.2 µM 0.113499904265084 0.475122635392575 no 1591 0.454817119488596 2139 4227577
SGTC_2718 lomofungin 53.02 µM 0.113139038286389 0.475264707748249 no 1592 0.454960162798291 2171 5351222 A RNA synthesis inhibitor.
SGTC_3141 9094609 49.47 µM 0.113088904473657 0.475284445598957 no 1593 0.454980035753382 2004 25236309 YDL196W YDL196W
SGTC_392 N-ethylmaleimide 8.33 µM 0.111472725764372 0.475920772818749 no 1594 0.455620746235551 2108 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_196 k015-0023 18.111 µM 0.110014773308862 0.476494855411844 no 1595 0.456198829314142 2066 5211998
SGTC_2545 solidagenone 89.61 µM 0.109326041419423 0.476766067159819 no 1596 0.456471946160824 2233 6708572 An anti ulcer agent
SGTC_2105 5350118 200 µM 0.108491141150596 0.477094852128027 no 1597 0.456803053687509 2105 2133313
SGTC_2036 5160441 105 µM 0.108297039287358 0.477171291972661 no 1598 0.456880035555643 2131 134534 YIL048W NEO1
SGTC_2053 5265679 138 µM 0.106543143326493 0.47786203681551 no 1599 0.457575713380545 2179 764595
SGTC_376 3970-0862 59.1 µM 0.106522690812189 0.477870092118808 no 1600 0.457583826582934 2216 3135186
SGTC_3081 9117243 49.47 µM 0.105609156255399 0.478229900473195 no 1601 0.457946229870742 2196 45595589
SGTC_3250 9135583 49.47 µM 0.105111015607678 0.478426107624979 no 1602 0.458143859267845 2230 7699353
SGTC_551 k048-0028 34.9 µM 0.104628144656394 0.478616305354887 no 1603 0.458335440532882 2201 6836383
SGTC_577 r071-0003 38.6 µM 0.103845634952996 0.478924537922436 no 1604 0.458645925380365 2202 4568517 YMR134W ERG29
SGTC_1264 0783-0040 158 µM 0.102596816816253 0.479416476605443 no 1605 0.459141484660791 2127 2855798
SGTC_1732 st034308 51.822 µM 0.102373109473588 0.479504603495061 no 1606 0.459230263522031 2004 830119
SGTC_1871 st057448 67.3 µM 0.102142343840383 0.479595511965399 no 1607 0.459321845615268 2199 691747
SGTC_1633 st005664 67.9 µM 0.101454841131926 0.479866355012068 no 1608 0.459594702039888 2190 2063822
SGTC_21 0849-0113 22.993 µM 0.101199050237919 0.479967126718154 no 1609 0.459696225324737 2173 1560156
SGTC_2789 5281112 71.43 µM 0.100599366823999 0.480203383767232 no 1610 0.459934249679487 2113 765948
SGTC_2815 7968870 71.43 µM 0.100125833011966 0.480389946623153 no 1611 0.460122213302711 2176 2977326 YHR190W ERG9
SGTC_595 3909-8003 73.7 µM 0.100096319689702 0.480401574424776 no 1612 0.460133928560966 2174 699517
SGTC_455 paf C-16 10 µM 0.0991634835916068 0.480769106249451 no 1613 0.460504233892517 2197 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_714 4296-0578 26.1 µM 0.0987336496227095 0.480938463774521 no 1614 0.460674875426727 2207 1589775
SGTC_2309 7664088 163.95 µM 0.0980784346164591 0.481196629579714 no 1615 0.460935005817975 2253 704922
SGTC_2358 9037157 4 µM 0.0977412039243968 0.481329507262505 no 1616 0.461068898090212 2156 2388925
SGTC_674 0498-0004 451 µM 0.0969743652756237 0.481631669376346 no 1617 0.46137337601441 2096 4231473
SGTC_1720 st037298 9.481 µM 0.0965225914752886 0.481809689515579 no 1618 0.461552766145447 2149 597396
SGTC_2861 9024595 19.48 µM 0.0954030161102099 0.482250870457211 no 1619 0.461997360249084 2249 16482810
SGTC_1317 1273-0028 910 nM 0.0948399011495231 0.482472780328034 no 1620 0.462220996579617 2158 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_866 0495-0101 262 µM 0.0932486033010243 0.483099901124501 no 1621 0.462853031357359 2028 635694
SGTC_1835 st008666 49.2 µM 0.0925291137496193 0.483383461397249 no 1622 0.463138830503989 2101 690455
SGTC_668 1682-0499 62.6 µM 0.0911893474716241 0.48391150315384 no 1623 0.463671069586623 2135 682214
SGTC_2033 5192550 145 µM 0.0910754738822195 0.48395638543801 no 1624 0.463716310320655 2178 182073
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0904698955217903 0.484195072279472 no 1625 0.463956907861012 2228 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1578 josamycin 24.2 µM 0.0886272331059727 0.484921386460464 no 1626 0.464689082178053 2085 5282165 A P450 substrate.
SGTC_1122 capsaicin 818.572 nM 0.0856980445844669 0.486076073886342 no 1627 0.465853228303496 2179 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_879 0831-1030 162 µM 0.0851864461471512 0.486277758468789 no 1628 0.466056582909459 2244 1549252
SGTC_2078 5212016 200 µM 0.0844645058726517 0.486562370893169 no 1629 0.466343561087371 2277 1899708
SGTC_974 1326-0144 138 µM 0.083930732698253 0.486772806113083 no 1630 0.466555752300554 2154 5411856
SGTC_2427 5545055 42.75 µM 0.0837435775543268 0.486846591201692 no 1631 0.466630154466278 2194 5372858
SGTC_1653 st012112 65 µM 0.0827045543416116 0.487256229631833 no 1632 0.467043231720543 2237 720429
SGTC_2076 5212012 200 µM 0.0826953846247662 0.48725984488433 no 1633 0.467046877419962 2267 604802
SGTC_2950 9072895 21.46 µM 0.0821887365917654 0.487459597552845 no 1634 0.467248315020166 2169 17332245
SGTC_1974 st069448 26.9 µM 0.0819340224024693 0.48756002317262 no 1635 0.467349589709282 2270 6323587 YNR016C ACC1
SGTC_404 fumagillin 50 µM 0.0816430534621934 0.48767474384053 no 1636 0.467465281919885 2150 12015870 A methionine aminopeptidase binder.
SGTC_2132 5317594 122.667 µM 0.0815952519146229 0.487693590710965 no 1637 0.467484288564576 2183 794577
SGTC_2416 tofa 880 nM 0.0813207027226554 0.487801838637901 no 1638 0.467593455061689 1993 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1098 clofazimine 15.1 µM 0.0807423343640181 0.488029877846703 no 1639 0.467823434375244 2247 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2196 6573537 42.6665 µM 0.0793436055787798 0.488581384983253 no 1640 0.468379661684248 2268 2903087
SGTC_8 0354-0001 70 µM 0.0783714446872862 0.488964712869031 no 1641 0.468766293743703 2210 4993152
SGTC_2390 9097792 176.6 µM 0.0780735228688283 0.489082186984217 no 1642 0.468884784290384 2118 4497149
SGTC_3229 9132204 49.47 µM 0.0773581896697994 0.489364255217531 no 1643 0.469169300439532 2189 17682924
SGTC_33 0986-0033 35.816 µM 0.0772725146440695 0.489398038719164 no 1644 0.469203377825723 2270 2848082
SGTC_2442 5158906 48.48 µM 0.0769815268268652 0.489512782027903 no 1645 0.46931912040438 2234 1893835
SGTC_2840 9008771 71.43 µM 0.076026351624208 0.489889436022137 no 1646 0.469699066650289 2264 2992978
SGTC_3022 9087993 49.47 µM 0.0751567760175301 0.49023234339887 no 1647 0.470044987391587 2277 17173644
SGTC_1743 st037606 46.3785 µM 0.0740183035779454 0.49068129809632 no 1648 0.470497910530629 2230 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_512 prima-1 270 µM 0.0729290880929834 0.491110839455024 no 1649 0.47093127330926 2251 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2405 ticlatone 3.52 µM 0.0718726274454381 0.491527473519108 no 1650 0.471351636915902 2309 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_389 tpck 16.7 µM 0.0713391585538859 0.491737860014418 no 1651 0.471563915292816 2203 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1281 0884-0031 11.8 µM 0.0712904445579714 0.491757071684681 no 1652 0.4715833000093 2251 1548255
SGTC_618 k072-0232 33.2 µM 0.0712450352097452 0.491774980095754 no 1653 0.471601369770934 2233 5872756 YGL099W LSG1
SGTC_2917 7979103 53.79 µM 0.0706178567922292 0.492022326636606 no 1654 0.471850949114038 2245 2980565
SGTC_2799 7812892 81.82 µM 0.0703980299466188 0.492109022649613 no 1655 0.471938429617486 2252 20205235
SGTC_3239 9133757 49.47 µM 0.0696629913918449 0.492398912184665 no 1656 0.472230949389639 2265 17036923
SGTC_1911 st060208 74.3 µM 0.0684528778944143 0.492876173699699 no 1657 0.472712565016189 2247 688783
SGTC_1313 1220-0047 237 µM 0.0676899243563223 0.493177083290038 no 1658 0.473016235057202 2217 3528706
SGTC_3048 9093155 49.47 µM 0.0663626921159688 0.493700554080348 no 1659 0.473544536038335 2303 25236002
SGTC_3163 9099914 49.47 µM 0.0662297261014416 0.493752997530578 no 1660 0.473597465358306 2289 16268368
SGTC_181 1447-1644 8.07 µM 0.0655192597807278 0.494033216093186 no 1661 0.473880286097244 2284 534600
SGTC_3260 9137109 49.47 µM 0.064782133769602 0.494323952747443 no 1662 0.474173733375989 2289 17478346
SGTC_296 1222-0039 74.9 µM 0.0644030419102501 0.494473475040433 no 1663 0.474324653981663 2223 5984176
SGTC_1255 0566-0045 221 µM 0.0641018006629543 0.494592291868579 no 1664 0.474444584037638 2214 2788469
SGTC_442 cape 100 µM 0.0627060190930425 0.495142827946635 no 1665 0.475000302142807 2285 5281787
SGTC_226 1,3-diallylurea 8.28947 mM 0.0617605685555329 0.495515745935308 no 1666 0.475376752622825 2239 74537 YKL182W FAS1
SGTC_1993 st073995 70.8 µM 0.061591581715658 0.495582400539757 no 1667 0.475444040516723 2209 3098394
SGTC_950 1165-0508 94.1 µM 0.0607382334040025 0.49591899424182 no 1668 0.475783841011385 2232 6148369
SGTC_639 0833-0042 114 µM 0.0593289773190885 0.496474865797468 no 1669 0.476345040598353 2246 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3287 9117173 37.0625 µM 0.0580078667086198 0.496995975201394 no 1670 0.47687118117649 2318 2789709
SGTC_3311 9131146 2.8755 µM 0.0549156940355952 0.498215694933774 no 1671 0.478102814356901 2195 4900406 YPR165W RHO1
SGTC_1162 k048-0130 20.1 µM 0.0536650027796531 0.498709040423292 no 1672 0.478601033169397 2260 6797406
SGTC_1004 4084-0029 199 µM 0.0522192867087685 0.499279317472014 no 1673 0.47917698266361 2316 716894 YLR208W SEC13
SGTC_1523 st012844 44.7 µM 0.0521144728080836 0.499320662426375 no 1674 0.479218740501931 2200 4274103
SGTC_78 0336-0123 156.75 µM 0.0515666505088166 0.499536756848873 no 1675 0.479436996504028 2156 6765896
SGTC_2432 5630864 12.22 µM 0.0513596566690877 0.499618407843319 no 1676 0.479519465817809 2267 5714970
SGTC_2025 5147754 141 µM 0.0507733532668144 0.499849681737829 no 1677 0.479753062247144 2300 315777 YLR208W SEC13
SGTC_2192 5915882 198.485 µM 0.0505799770403359 0.499925961154864 no 1678 0.479830109203162 2296 2876149
SGTC_1809 st050081 57.6 µM 0.0502045847645163 0.499925961154864 no 1679 0.479979679024778 2280 5036894
SGTC_902 1120-0002 2.07 µM 0.0501110887973478 0.499889080623584 no 1680 0.480016931629418 2302 3280475
SGTC_3353 9151644 39.2805 µM 0.0490743158396288 0.49948011405452 no 1681 0.480430035864733 2281 4909158
SGTC_2389 9091542 195.52 µM 0.0490008026415421 0.499451115975517 no 1682 0.480459328147114 2202 3626624 YOL127W RPL25
SGTC_3067 9117431 49.47 µM 0.048864427141417 0.499397321186873 no 1683 0.480513669004228 2265 17150885
SGTC_3347 9188721 44.724 µM 0.0470885629123809 0.498696813723767 no 1684 0.48122132135044 2260 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_115 0527-0192 112.043 µM 0.046644120608595 0.498521499541948 no 1685 0.481398433558908 2190 4233931
SGTC_1816 st051957 91.6 µM 0.0466022355496958 0.498504977625695 no 1686 0.481415125128551 2323 674121
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0465183958685771 0.498471906361079 no 1687 0.481448536087289 2312 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2922 7999257 32.47 µM 0.0454086975502531 0.498034177639177 no 1688 0.481890774248775 2326 2988377
SGTC_328 k915-0120 63.5 µM 0.0447375012934595 0.497769420418668 no 1689 0.48215827094994 2318 6624543
SGTC_49 0717-0965 32.132 µM 0.0438118258058538 0.497404284039141 no 1690 0.482527200253392 2292 5889349 YGL099W LSG1
SGTC_2084 5306078 60.6385 µM 0.0431632470487099 0.497148450844911 no 1691 0.482785701187591 2288 679340
SGTC_2824 7998404 51.95 µM 0.0429203171999 0.497052626974059 no 1692 0.482882526444669 2293 837851
SGTC_448 monastrol 171 µM 0.0427459184074862 0.496983835337102 no 1693 0.482952037701952 2284 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1672 st016598 6.51 µM 0.0426419514534856 0.496942825594789 no 1694 0.482993476731481 2201 4665860 YNL267W PIK1
SGTC_1612 st002233 45.4 µM 0.0425849959809777 0.496920359534759 no 1695 0.483016178056441 2325 1035021
SGTC_1936 st074407 74.3 µM 0.0410810924724856 0.496327149237046 no 1696 0.483615623949406 2333 809813
SGTC_1139 k015-0024 46.9 µM 0.0410015597437483 0.496295778001635 no 1697 0.48364732620683 2335 2766652
SGTC_3283 9109332 35.8195 µM 0.0406834869339002 0.496170316210151 no 1698 0.483774113106922 2337 17027281
SGTC_1668 st014914 51.6 µM 0.0393599602976947 0.49564826377638 no 1699 0.484301701104657 2322 2839556
SGTC_3203 9113543 49.47 µM 0.0372423762993006 0.494813018876494 no 1700 0.485145875316039 2280 17018012
SGTC_2301 7769476 200 µM 0.036146805120842 0.494380898200506 no 1701 0.485582650801913 2300 977820
SGTC_779 1360-0071 233 µM 0.0358133350702 0.494249370557082 no 1702 0.485715600020157 2344 7566
SGTC_3335 9143315 29.6265 µM 0.0341001479744993 0.493573663486164 no 1703 0.486398645244196 2284 4899691
SGTC_2592 piperlongumine 83.33 µM 0.0331578799902605 0.493202026384358 no 1704 0.486774343268177 2318 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1651 st011928 86.1 µM 0.0329308551715188 0.493112487073403 no 1705 0.486864863632424 2328 720198
SGTC_3096 9117468 49.47 µM 0.0325946938832363 0.492979904630242 no 1706 0.486998900625802 2346 41316311
SGTC_2303 7774051 200 µM 0.0319664439360722 0.492732124135824 no 1707 0.487249405536803 2334 2953184
SGTC_1018 4259-0013 28.1 µM 0.0318243960670017 0.492676101132024 no 1708 0.487306045619757 2281 6801262
SGTC_1389 3405-0187 19 µM 0.0307532066748596 0.492253633861541 no 1709 0.487733179207447 2322 799890
SGTC_1021 4476-0760 85.3 µM 0.0301099515761037 0.491999944096209 no 1710 0.487989682060292 2338 746768
SGTC_1428 4049-0204 61.7 µM 0.0299139067419252 0.491922627713862 no 1711 0.488067857418552 2350 X1428
SGTC_164 4100-3994 89.624 µM 0.0293866893391337 0.491714704634701 no 1712 0.488278094294899 2358 4615967
SGTC_967 1306-0166 352 µM 0.0289083611781079 0.491526064355613 no 1713 0.488468838577115 2352 4437607
SGTC_2292 7671323 168.05 µM 0.0286749923061831 0.491434030382011 no 1714 0.488561900706427 2311 937504
SGTC_332 4112-0506 40.9 µM 0.028347364919528 0.491304824330796 no 1715 0.488692552009412 2347 2790355
SGTC_1913 st060213 96.1 µM 0.0283131389442172 0.491291326723052 no 1716 0.488706200719702 2346 688959
SGTC_3165 9101544 49.47 µM 0.0283007107562877 0.491286425453777 no 1717 0.488711156863304 2344 5002184
SGTC_802 4112-3352 742 µM 0.0280857995296696 0.491201671730707 no 1718 0.48879685997023 2332 704594
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0280736106882736 0.491196864875551 no 1719 0.488801720697766 2372 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2878 9043973 25.97 µM 0.0280474551336032 0.491186550038714 no 1720 0.488812151147148 2331 6465167
SGTC_2267 7931562 200 µM 0.0272728606691288 0.490881079749374 no 1721 0.489121051431484 2352 934880
SGTC_1352 1496-0991 99 µM 0.0270560983655272 0.490795597976973 no 1722 0.489207495179326 2340 3000039
SGTC_2499 avocadenofuran 51.48 µM 0.0266307923684395 0.490627876732254 no 1723 0.489377106602886 2363 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0262837332080146 0.490491013689785 no 1724 0.489515514724682 2363 1273210
SGTC_371 0195-0006 7.36 µM 0.0260333511809757 0.490392276042274 no 1725 0.489615368531966 2329 3928593
SGTC_2474 5321570 43.32 µM 0.0255994974610131 0.490221188100035 no 1726 0.489788393453907 2337 2841384
SGTC_2772 vinpocetine 57.06 µM 0.0253308566546082 0.490115251904913 no 1727 0.489895530885882 2348 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_592 k241-0073 46.5 µM 0.0252882835354267 0.490098463624764 no 1728 0.489912509664175 2363 4230158
SGTC_2361 9034121 116 µM 0.025215337290987 0.490069698049814 no 1729 0.489941601728459 2337 6496917
SGTC_2158 5657123 3.6195 µM 0.0250515708868401 0.490005118700068 no 1730 0.490006914439142 2372 2858827
SGTC_1269 0831-0796 3.05 µM 0.0240876872325207 0.48962502791584 no 1731 0.490391332319717 2367 927758
SGTC_1407 3909-7909 12.3 µM 0.0239336218923119 0.489564275788161 no 1732 0.490452777783247 2361 4411780
SGTC_2673 kobusone 100 µM 0.0230374701032787 0.48921090376167 no 1733 0.490810192026358 2365 6710676 An epoxy ketone and protein crosslinker.
SGTC_1233 0325-0408 14.2 µM 0.0223841379761401 0.488953286099943 no 1734 0.491070766622056 2349 12874
SGTC_2093 5331342 194.4 µM 0.0208581613946296 0.488351591110237 no 1735 0.49167940086328 2371 33839
SGTC_464 bw-b 70c 158 µM 0.020836422479193 0.488343019609633 no 1736 0.491688071551391 2357 5353454
SGTC_1032 k061-1018 98.7 µM 0.0203443194042776 0.488148988295778 no 1737 0.491884350660323 2363 4005393
SGTC_699 0375-0592 111 µM 0.0199003988206946 0.487973957260864 no 1738 0.492061413497974 2371 762578
SGTC_1929 genistein trimethyl ether 50.5 µM 0.0194888550305701 0.487811693964229 no 1739 0.492225563876659 2387 136420
SGTC_1092 toremifene 6.32 µM 0.01881855773866 0.487547413786888 no 1740 0.492492924754734 2373 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1955 wogonin 32.4 µM 0.0185085540600059 0.487425189524159 no 1741 0.492616576791106 2357 5281703 A flavanone.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0172898617173099 0.486944710740457 no 1742 0.493102686786735 2364 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_316 k060-0003 58.6 µM 0.0172886447377713 0.486944230946314 no 1743 0.493103172218769 2364 6152314
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0170501634422859 0.486850210069092 no 1744 0.493198298468305 2323 688788
SGTC_1493 4348-0038 111 µM 0.0168832385584568 0.486784400629621 no 1745 0.493264882277643 2371 800424
SGTC_1217 1183-1422 255 µM 0.0166628005409103 0.486697494412024 no 1746 0.493352811953191 2365 2849664
SGTC_1923 st058458 19.1 µM 0.0165765496129263 0.486663490730874 no 1747 0.493387216343268 2379 3534982
SGTC_98 0074-0023 107.663 µM 0.016389048429981 0.486589570348691 no 1748 0.493462008332128 2345 3563821
SGTC_3204 9114183 49.47 µM 0.015160589422459 0.486105274735824 no 1749 0.493952031565472 2376 17027248
SGTC_897 1000-0139 31.4 µM 0.0150763711747748 0.486072074103535 no 1750 0.493985625945718 2364 6151020
SGTC_79 0052-0007 94.094 µM 0.014993402242748 0.486039366072569 no 1751 0.494018722019794 2382 2801472
SGTC_839 0122-0028 230 µM 0.0149228389003781 0.48601154864983 no 1752 0.494046869571388 2372 759448
SGTC_2274 7947094 46.08 µM 0.0144237357304752 0.485814794560282 no 1753 0.494245961492146 2377 2971028
SGTC_907 3448-6986 75.5 µM 0.014258197120992 0.485749537473339 no 1754 0.494311995051742 2372 590582
SGTC_2961 9083290 32.55 µM 0.0141951439769626 0.485724681351153 no 1755 0.494337147071314 2387 17741490
SGTC_1555 citronellol 128 µM 0.0137287278593021 0.485540817609334 no 1756 0.494523202043965 2379 8842 A terpine precursor.
SGTC_944 3370-0224 231 µM 0.0136561569587232 0.48551221004542 no 1757 0.494552150930688 2372 4580514
SGTC_22 0964-0034 14.468 µM 0.0130231089477395 0.485262664695314 no 1758 0.494804678074504 2376 138402
SGTC_1709 st033179 39.1045 µM 0.0128112934698375 0.48517916904573 no 1759 0.494889173174654 2384 573381
SGTC_2965 9082772 38.63 µM 0.0120138233429763 0.484864819754796 no 1760 0.495207293209611 2385 16459634
SGTC_951 1171-0579 82.7 µM 0.0111627441499141 0.484529349053322 no 1761 0.495546801876658 2377 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2260 7964312 200 µM 0.0108786493783969 0.48441736957081 no 1762 0.495660132409744 2389 231951
SGTC_781 4335-2806 94.4 µM 0.0108427375511065 0.484403214565387 no 1763 0.495674458311088 2379 845254
SGTC_941 3237-0776 460 µM 0.0105485484529342 0.484287257735534 no 1764 0.495791816067492 2380 760008
SGTC_3051 9093778 49.47 µM 0.0103088703322187 0.484192787796358 no 1765 0.495887428603849 2386 17217378
SGTC_2438 5259590 200 µM 0.0094206513239161 0.483842701058986 no 1766 0.496241759467861 2381 1201127
SGTC_3288 9119690 36.221 µM 0.00921574797937788 0.483761941267821 no 1767 0.496323500526432 2384 17595618 YKL019W RAM2
SGTC_107 0358-0022 2.6945 µM 0.00911954488075529 0.483724024389865 no 1768 0.496361878397182 2357 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3100 9120536 49.47 µM 0.00907672189169402 0.483707146456401 no 1769 0.496378961591036 2393 16421196
SGTC_3243 9134147 49.47 µM 0.00874121427592333 0.483574913000264 no 1770 0.496512804452096 2393 24282180
SGTC_1891 st059073 26.2 µM 0.00843848346624138 0.483455599401087 no 1771 0.496633572115663 2393 688754
SGTC_2403 6032726 181.2 µM 0.00804107238436952 0.483298972246973 no 1772 0.496792110815879 2387 2881040
SGTC_2148 5546263 113.568 µM 0.00792030370265477 0.48325137555602 no 1773 0.496840289014842 2387 792097
SGTC_625 k213-0058 121 µM 0.00732362370636452 0.483016218821898 no 1774 0.497078322975388 2383 3655420
SGTC_801 0866-0028 10.1 µM 0.00708320597001437 0.482921469783146 no 1775 0.497174233286759 2396 6849771
SGTC_2069 5228469 200 µM 0.00696352532849643 0.482874303798034 no 1776 0.497221977777201 2383 2835210
SGTC_1620 st003704 16.5 µM 0.00694583407626043 0.482867331718862 no 1777 0.497229035395029 2387 2834414
SGTC_260 nsc-65238 3.989 µM 0.00596647084592247 0.48248137530184 no 1778 0.497619736637197 2393 3246252
SGTC_918 glabranin 770.725 nM 0.00574718354177628 0.48239495879257 no 1779 0.497707218113775 2391 124049 Also referred to as licorice root.
SGTC_722 3534-0461 190 µM 0.00566463212848266 0.482362427232864 no 1780 0.497740150826729 2393 658262
SGTC_511 blebbistatin 171 µM 0.00527534922516826 0.482209021633087 no 1781 0.497895449911565 2395 3476986 A myosin inhibitor.
SGTC_2781 5567276 71.43 µM 0.00396707095243447 0.481693484868804 no 1782 0.498417371818865 2395 2853274
SGTC_2743 auranofin 4.32 µM 0.00374287738674622 0.481605142778645 no 1783 0.498506811446448 2394 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2335 9018011 154.17 µM 0.00364347298215764 0.481565973375624 no 1784 0.498546467795832 2397 6458208
SGTC_3041 9091929 49.47 µM 0.00339666293970328 0.481468720889719 no 1785 0.498644930146726 2380 25236887
SGTC_3178 9107506 49.47 µM 0.00198184316484655 0.480911249876273 no 1786 0.499209359485985 2397 8897194
SGTC_2167 5876490 200 µM 0.00146836615023943 0.4807089374857 no 1787 0.499414206870064 2402 686534
SGTC_906 1165-0455 526 µM 0.00027285436800955 0.480237919487594 no 1788 0.499891146857559 2404 3252859
SGTC_1445 4239-0156 97.7 µM 0.000227734571825156 0.480220143339028 no 1789 0.499909147051375 2405 4008346
SGTC_1178 0988-0033 191 µM 0 0.480130421824185 no 1790 0.5 2405 5392207
SGTC_2619 obliquin 87.91 µM -0.000310710232592797 0.48000801167554 no 1791 0.49987604455326 2407 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3251 9135047 49.47 µM -0.00122801969431547 0.479646631377944 no 1792 0.499510091145905 2409 17682963
SGTC_1041 0206-0046 107 µM -0.00126549389115394 0.47963186851704 no 1793 0.499495141115982 2413 50494
SGTC_1755 st041960 45.185 µM -0.00193952234407835 0.479366341577897 no 1794 0.499226243018277 2409 2257073
SGTC_532 1548-0774 215 µM -0.00221637513285434 0.479257280766511 no 1795 0.49911579497419 2411 5932993
SGTC_736 0958-0254 92.6 µM -0.00225109694445034 0.47924360288858 no 1796 0.499101943010051 2411 6812352
SGTC_1758 st042942 75.2445 µM -0.00247336571985842 0.479156045675727 no 1797 0.499013270845512 2409 669317
SGTC_1802 st050112 57.9 µM -0.00466545476535621 0.478292581685689 no 1798 0.498138759588907 2404 4662563
SGTC_1304 1165-0502 251 µM -0.0065234329650674 0.477560803584529 no 1799 0.497397545234871 2419 767425
SGTC_1071 trifluoperazine 6.31 µM -0.00712996662360272 0.477321932192423 no 1800 0.497155578956047 2429 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2540 epiandrosterone 100 µM -0.00805680706443186 0.476956930019888 no 1801 0.496785833790067 2419 441302 A steroid.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.00889039938345178 0.476628666708783 no 1802 0.496453290517862 2422 260807
SGTC_3164 9100705 49.47 µM -0.00889512450275417 0.476626806032087 no 1803 0.496451405542527 2441 17174235
SGTC_254 nsc-64875 3.808 µM -0.00912989619161319 0.476534357324153 no 1804 0.496357748993535 2421 56993
SGTC_3076 9116187 49.47 µM -0.00956915163331364 0.476361390128109 no 1805 0.496182519086258 2429 27241210
SGTC_71 0417-1750 47.813 µM -0.0106941426188804 0.475918418767063 no 1806 0.495733735675171 2424 6811472
SGTC_2172 5754775 163.918 µM -0.0110858493970576 0.475764189035454 no 1807 0.495577476546652 2424 2263357
SGTC_1007 4101-0031 70 µM -0.0116929416727797 0.475525161093512 no 1808 0.495335297481522 2434 1146276
SGTC_35 0133-0054 64.071 µM -0.0117315695251805 0.475509952605377 no 1809 0.49531988825493 2445 99677
SGTC_943 3253-1379 105 µM -0.013205104959559 0.474929821747076 no 1810 0.494732078413731 2435 668464
SGTC_482 fipronil 114 µM -0.0142437907333709 0.474520923051531 no 1811 0.494317741785288 2429 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3231 9132313 49.47 µM -0.0154272151893077 0.474055077913666 no 1812 0.493845675713574 2447 4905967
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0159747138956193 0.473839571591334 no 1813 0.493627282254757 2443 641818
SGTC_37 0566-0070 1.56 µM -0.0160930294646728 0.473793001246427 no 1814 0.493580087238816 2455 1626686
SGTC_353 1988-1175 58.3 µM -0.0162338324220912 0.473737580078136 no 1815 0.493523922323146 2385 2788357
SGTC_2785 7756463 72.73 µM -0.0167276692196118 0.473543205996305 no 1816 0.493326936700955 2442 2201551
SGTC_2483 5729050 27.16 µM -0.0178457367698228 0.473103158138973 no 1817 0.492880958946823 2450 2865180
SGTC_2625 euphol 100 µM -0.0178756031523206 0.473091403807088 no 1818 0.492869045884389 2443 6708538 A triterpene alcohol.
SGTC_3206 9114350 49.47 µM -0.0179608103349017 0.473057869459364 no 1819 0.492835058593128 2428 17087243
SGTC_4 0960-0234 25.671 µM -0.0197836844813235 0.472340500764572 no 1820 0.492107966617614 2404 6821112
SGTC_1956 st077085 54 µM -0.0198046713099077 0.472332242185805 no 1821 0.492099595724419 2460 24208685
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0207568848848191 0.471957546837722 no 1822 0.49171979559958 2416 368090
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0217261443469537 0.471576169435247 no 1823 0.491333204259805 2438 16725076
SGTC_1700 st030840 7.9285 µM -0.0217444265479491 0.471568976132599 no 1824 0.491325912439463 2450 5499307
SGTC_2046 4110841 106 µM -0.0219981260449891 0.471469156655566 no 1825 0.491224725188342 2449 44119630 YMR134W ERG29
SGTC_465 cgp-37157 41 µM -0.0220456157384486 0.47145047177071 no 1826 0.491205784135149 2445 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_808 0711-0032 135 µM -0.0221023671849221 0.471428142918884 no 1827 0.491183149098938 2440 4252555
SGTC_1274 0865-0114 173 µM -0.0225850502245636 0.471238234955135 no 1828 0.490990634489883 2466 870624
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.023986131371288 0.470687027452534 no 1829 0.490431835544042 2468 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_112 phenothiazine 287.218 µM -0.0241378849130104 0.47062732855869 no 1830 0.490371312163563 2449 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_794 k038-0031 316 µM -0.0244997010199448 0.470484995031663 no 1831 0.490227011097965 2436 6624242
SGTC_3036 9090181 49.47 µM -0.0276436996131249 0.469248349511166 no 1832 0.488973163859307 2445 25236586
SGTC_2520 obtusaquinone 4.71 µM -0.0277710551484436 0.469198262258263 no 1833 0.488922375850347 2480 5967872
SGTC_600 1495-0418 41.6 µM -0.0280177251391749 0.469101251590261 no 1834 0.488824007039671 2461 5377768
SGTC_624 k048-0052 28 µM -0.0288223401478456 0.468784824421359 no 1835 0.488503141709272 2480 6835531
SGTC_2544 sphondin 68.51 µM -0.0288713235931416 0.468765561566371 no 1836 0.488483608270872 2452 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1129 3453-1384 223 µM -0.0293738778327455 0.468567935161882 no 1837 0.488283203141016 2571 1084452
SGTC_643 k048-0106 28.4 µM -0.029522889689796 0.468509338640044 no 1838 0.488223781781918 2513 6763920
SGTC_495 decylubiquinone 155 µM -0.0296782493487477 0.468448246673383 no 1839 0.488161829392449 2505 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_372 0155-0182 15.9 µM -0.0297761035407006 0.468409767921318 no 1840 0.488122808463285 2455 771486
SGTC_2539 epi(13)torulosol 80 µM -0.030909401237462 0.467964148093871 no 1841 0.487670896201712 2492 6708597
SGTC_953 1188-0045 9.7 µM -0.0313956390575508 0.467772968578459 no 1842 0.487477009483231 2496 6144426
SGTC_1764 st044502 93.5 µM -0.0316541587743656 0.467671326538489 no 1843 0.487373926273931 2504 8407
SGTC_76 0433-0009 400.328 µM -0.0327958442599047 0.467222476047338 no 1844 0.486918696115957 2562 2841569
SGTC_1321 1326-2144 215 µM -0.0329054181768721 0.467179399547763 no 1845 0.486875006028417 2455 3513030
SGTC_1364 1653-0028 37.6 µM -0.034191850039647 0.466673696927665 no 1846 0.48636208273445 2506 5718652
SGTC_2096 5468907 200 µM -0.0353207538992061 0.466229963620908 no 1847 0.485911987218178 2489 759785
SGTC_2681 menadione 3.18 µM -0.0358869871971345 0.46600741254562 no 1848 0.485686235948604 2495 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1654 st012436 41.8 µM -0.0359737164894208 0.4659733255946 no 1849 0.485651658293885 2470 4323132
SGTC_1959 st077091 55.8 µM -0.0363143298082256 0.465839457791314 no 1850 0.485515861970885 2464 821356 YKL052C ASK1
SGTC_1416 3966-0321 25.3 µM -0.0374958439677962 0.465375129300268 no 1851 0.485044826925801 2488 582530 YLR208W SEC13
SGTC_849 0386-0493 241 µM -0.037780958282349 0.465263087996933 no 1852 0.48493116331062 2480 726119
SGTC_2404 5161160 200 µM -0.0387719182810763 0.464873692160373 no 1853 0.484536116979485 2479 2831543
SGTC_2662 daunorubicin 22.37 µM -0.0394226510108752 0.464618006251615 no 1854 0.484276710524737 2431 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_766 1391-0721 126 µM -0.0406039965259068 0.464153869371804 no 1855 0.483805799009549 2480 1020919 YIL115C NUP159
SGTC_2336 9001819 198.65 µM -0.0413505701287911 0.463860574420635 no 1856 0.483508209192891 2504 2989602
SGTC_2251 lansoprazole 556 µM -0.0414811419896 0.463809280664293 no 1857 0.483456163212702 2486 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1947 st076332 61.6 µM -0.0415557646657108 0.463779966215712 no 1858 0.483426418719693 2469 24208416
SGTC_1790 st045711 43.5 µM -0.0431080029592642 0.463170236478677 no 1859 0.48280771989617 2489 585119
SGTC_957 1187-1561 14.1 µM -0.0434539215536122 0.463034369044348 no 1860 0.482669847538612 2468 1538454
SGTC_2397 5161689 200 µM -0.0454734865024803 0.462241225335313 no 1861 0.481864953868359 2527 2259942
SGTC_1885 st057546 99.9 µM -0.0477669821904366 0.461340683019878 no 1862 0.480950975449983 2627 702008
SGTC_1471 k673-0312 37 µM -0.0479247292971355 0.461278750765687 no 1863 0.480888115451138 2503 24099884
SGTC_2487 5918373 44.05 µM -0.0507223764659728 0.460180538752646 no 1864 0.479773372878022 2493 2876279
SGTC_2787 5284540 71.43 µM -0.0510823676681147 0.460039246647407 no 1865 0.479629943105069 2530 736958
SGTC_1439 4092-1168 46 µM -0.0517690395523952 0.459769750412249 no 1866 0.479356362658149 2505 2886240
SGTC_1745 st081495 74 µM -0.0543672342031002 0.458750212372645 no 1867 0.478321291774006 2526 13842402 YBL026W LSM2
SGTC_949 1165-0505 146 µM -0.0544680262784244 0.458710666734557 no 1868 0.478281141046422 2506 6244267
SGTC_2393 9031399 185.94 µM -0.0553159016285137 0.458378020171486 no 1869 0.477943396947402 2548 1526623 YDL150W RPC53
SGTC_619 1652-1634 108 µM -0.0560949320764388 0.45807240918614 no 1870 0.477633090600331 2530 5400454
SGTC_220 paclitaxel 373.376 µM -0.0574870312398233 0.457526355271226 no 1871 0.477078618297946 2529 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2981 9013952 38.96 µM -0.0580205713551349 0.45731709419919 no 1872 0.476866121277928 2564 2996344
SGTC_2635 hydroquinidine 100 µM -0.0582472936805556 0.45722817446139 no 1873 0.476775824866391 2522 442912 An experimental heart treatment.
SGTC_3101 9120531 49.47 µM -0.0593953151865696 0.45677795722922 no 1874 0.476318622206674 2509 24824904
SGTC_1652 st011932 78 µM -0.0597114892012951 0.456653973634785 no 1875 0.476192710502558 2506 1551076
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0598902218702087 0.456583887771673 no 1876 0.476121533866874 2483 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_476 mead acid 10 µM -0.0610978626129913 0.456110375015699 no 1877 0.475640635680201 2512 5312531 An omega 9 fatty acid.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0620376980531596 0.455741911105862 no 1878 0.475266405549605 2579 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1938 st074717 56.4 µM -0.0627543007476993 0.455460991490785 no 1879 0.474981078410028 2492 17250979
SGTC_1140 3229-1848 2.98 µM -0.0637170177652155 0.455083626237503 no 1880 0.47459777703201 2509 2849525
SGTC_416 estradiol valerate 100 µM -0.0647382257073012 0.454683378048722 no 1881 0.474191213465325 2556 13791 A steroid.
SGTC_350 k064-0020 19.8 µM -0.0653776102512026 0.454432803600821 no 1882 0.473936675182843 2549 2790705
SGTC_2726 cimetidine 79.27 µM -0.0655585003490533 0.45436191615827 no 1883 0.473864664960569 2521 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_356 1634-0012 32.5 µM -0.0662938734662818 0.45407375219168 no 1884 0.473571930381145 2515 735457
SGTC_850 0388-0143 75.9 µM -0.0667529679228545 0.453893863274837 no 1885 0.473389183002985 2540 67273
SGTC_2829 7992743 58.44 µM -0.06759482551152 0.453564019266197 no 1886 0.473054087311744 2546 16462845
SGTC_306 1672-3436 11.6 µM -0.0681327233800309 0.45335328495052 no 1887 0.472839990690233 2589 6797378
SGTC_2838 9002687 71.43 µM -0.0687361228354197 0.45311690446046 no 1888 0.472599832161729 2529 6457060
SGTC_3226 9131256 49.47 µM -0.0694807359801276 0.452825226705866 no 1889 0.472303483026262 2510 17178073
SGTC_2755 lomerizine 42.69 µM -0.069841212898381 0.452684030840999 no 1890 0.472160022048913 2550 3949 A calcium channel blocker.
SGTC_1228 0124-0032 52.5 µM -0.0698474504228211 0.452681587706224 no 1891 0.472157539698817 2569 X1228
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0734005508327096 0.451290191232571 no 1892 0.470743689639207 2624 165506
SGTC_2925 9010536 32.5 µM -0.0736519648732037 0.451191759791052 no 1893 0.470643660698349 2582 2994177
SGTC_1100 amiodarone 5.07 µM -0.0740789171674512 0.451024610015919 no 1894 0.470473795411694 2539 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1903 st060211 78.3 µM -0.0755275010133992 0.450457561279341 no 1895 0.469897508688588 2545 688960
SGTC_1207 2099-0101 141 µM -0.076057877310054 0.450249970489284 no 1896 0.469686526031209 2581 5837381
SGTC_1765 st044815 90.4 µM -0.0766728918018342 0.45000926911506 no 1897 0.469441885124971 2605 645695
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0800677693347811 0.448680931783624 no 1898 0.468091678383221 2647 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2798 7813637 45.45 µM -0.0805494293901672 0.448492515545786 no 1899 0.467900142473806 2629 956368
SGTC_2400 5203494 178.7 µM -0.0812529143037214 0.448217346535907 no 1900 0.467620409529421 2548 6777674
SGTC_32 0928-0142 34.1 µM -0.0815171613723889 0.448113992391738 no 1901 0.467515338747836 2561 2244242
SGTC_522 1273-0010 11.6 µM -0.0817198329291308 0.448034724474611 no 1902 0.467434753355447 2780 5705015
SGTC_1805 st050013 60.3 µM -0.0823447808136817 0.447790310964133 no 1903 0.467186272683783 2621 4037144
SGTC_2948 9070189 9.45 µM -0.0831283566069256 0.447483887011671 no 1904 0.466874739280742 2598 6473636 YDL196W YDL196W
SGTC_26 0302-0163 425.158 µM -0.0835672820234522 0.447312255192488 no 1905 0.466700240538479 2573 3100915
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0852315617112689 0.446661566299391 no 1906 0.466038649624718 2536 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2741 miltefosine 3.04 µM -0.085812116247625 0.44643461867509 no 1907 0.465807887318276 2579 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3134 9127454 49.47 µM -0.0867265875850786 0.446077173490388 no 1908 0.465444421100497 2536 24262820
SGTC_2056 5235370 200 µM -0.0874141382708185 0.445808455054105 no 1909 0.465171165841019 2610 5511916
SGTC_1115 galangin 695.678 nM -0.088920670625587 0.44521973762829 no 1910 0.464572477919941 2566 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1307 1187-1599 12.2 µM -0.0904412625170323 0.444625648553365 no 1911 0.463968284140328 2568 1538471
SGTC_2968 9090663 33.37 µM -0.0907760527481923 0.444494864029763 no 1912 0.463835269306067 2680 25236811
SGTC_1739 st037196 92.5 µM -0.0909309676944893 0.444434349142536 no 1913 0.463773721727042 2594 612214
SGTC_3304 9125678 46.087 µM -0.0925175458688809 0.443814654190339 no 1914 0.463143425709774 2600 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_370 0180-0345 38.7 µM -0.0943060805291698 0.443116242665357 no 1915 0.462433009940414 2544 3989527
SGTC_2362 9071156 126 µM -0.0953348159029826 0.442714607882286 no 1916 0.462024444744923 2669 653133
SGTC_2564 betulinic acid 100 µM -0.096264219092296 0.442351804575998 no 1917 0.461655364049991 2634 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2519 cryptotanshinone 88.04 µM -0.0970111386824617 0.442060270880511 no 1918 0.461358774392483 2605 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3282 9108498 15.4605 µM -0.0983411958393149 0.441541207810085 no 1919 0.460830683574678 2666 16459645
SGTC_1648 st011736 69.8 µM -0.0990770897078698 0.441254063731905 no 1920 0.460538531168517 2688 2855514
SGTC_2508 celastrol 40.54 µM -0.0991946091651949 0.441208210767952 no 1921 0.460491877506593 2561 122724 Celastrol is a natural product and antioxidant.
SGTC_1251 0490-5699 265 µM -0.0998288737117603 0.440960751245018 no 1922 0.460240092319922 2595 3883818
SGTC_764 1951-2361 146 µM -0.100085496649116 0.440860635860739 no 1923 0.460138224755424 2593 5438930
SGTC_973 1325-0077 65.9 µM -0.100572159978565 0.440670786030571 no 1924 0.459945048871642 2669 2835149
SGTC_2759 disulfiram 3.38 µM -0.102259296983015 0.440012731188912 no 1925 0.45927543109595 2596 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3218 9131285 49.47 µM -0.102850837789297 0.439782044372081 no 1926 0.459040678224425 2618 17156417
SGTC_504 lovastatin 124 µM -0.103051233275779 0.439703899540257 no 1927 0.458961154543252 2595 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3172 9105863 49.47 µM -0.103383186485272 0.439574458542855 no 1928 0.458829427939665 2595 2348785
SGTC_1283 0922-0125 16.4 µM -0.104510535412331 0.439134911247022 no 1929 0.458382104007527 2670 3360884
SGTC_2649 anisomycin 9.56 µM -0.105479431418722 0.438757203832527 no 1930 0.457997695141881 2637 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1285 0929-0069 65.5 µM -0.107496757139902 0.437970963473811 no 1931 0.457197448922214 2626 1206237
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.10896292456059 0.437399687126978 no 1932 0.456615948552731 2710 5024745
SGTC_1900 st060200 72.8 µM -0.1095903440493 0.437155259675999 no 1933 0.456367134431375 2581 688945
SGTC_1777 st045864 34.765 µM -0.11001995203571 0.436987908628672 no 1934 0.456196775766611 2612 4691462
SGTC_2985 9022375 71.43 µM -0.110439814543562 0.436824364764197 no 1935 0.456030289397082 2805 4939335
SGTC_178 4092-0806 87.505 µM -0.110529806617175 0.436789312665767 no 1936 0.455994606210446 2591 2169044
SGTC_2151 5563267 85.4165 µM -0.113352945878345 0.435689947470271 no 1937 0.454875371472614 2654 5310824
SGTC_2958 9077254 16.72 µM -0.114266645663217 0.435334247520201 no 1938 0.454513211092677 2745 16457351
SGTC_536 3852-0578 10.6 µM -0.115190857003701 0.434974508683069 no 1939 0.454146922745355 2775 2869208
SGTC_760 0568-0725 82.9 µM -0.115390346139567 0.434896866839588 no 1940 0.454067865257532 2745 3916171
SGTC_509 pifithrin 175 µM -0.115961986412744 0.434674396433608 no 1941 0.453841334469285 2618 4817 A p53 inhibitor.
SGTC_1760 st045453 10.4495 µM -0.11688682644037 0.434314511919098 no 1942 0.453474868783602 2630 3323419 YIL048W NEO1
SGTC_2614 arthonioic acid 13.39 µM -0.117212208572103 0.434187908365571 no 1943 0.453345946283522 2602 6710684
SGTC_826 1683-5028 118 µM -0.117420939818627 0.434106696280305 no 1944 0.453263245638761 2688 722377
SGTC_2435 5706476 10.6 µM -0.118065438703618 0.433855955517847 no 1945 0.453007903896731 2665 5725375
SGTC_2038 4100038 30.985 µM -0.118071452301038 0.4338536160672 no 1946 0.453005521482087 2705 3596803
SGTC_1908 st060353 56.5 µM -0.118384024994295 0.433732020100242 no 1947 0.452881691486172 2727 4227716
SGTC_2375 9072683 200 µM -0.118818377637261 0.433563060125808 no 1948 0.452709624288935 2606 16798029
SGTC_2295 7971645 200 µM -0.119868037444168 0.433154800380497 no 1949 0.452293842150173 2702 2978226 YKL099C UTP11
SGTC_677 0929-0063 136 µM -0.120571480972996 0.432881239554145 no 1950 0.452015229448101 2622 1539583
SGTC_2006 4011487 200 µM -0.122079265465149 0.432294988604976 no 1951 0.451418121401849 2720 45595294
SGTC_3351 9150312 21.596 µM -0.12256889075212 0.432104646383656 no 1952 0.451224245117713 2601 4904905
SGTC_1767 st044992 70.3 µM -0.123191958435727 0.431862451115916 no 1953 0.450977546651623 2657 9600693
SGTC_1567 st069303 68.4 µM -0.123395068810333 0.431783504755585 no 1954 0.450897130876221 2717 5581319
SGTC_1626 st003712 1.76 µM -0.125827223488948 0.430838370383531 no 1955 0.449934345903645 2757 24207035
SGTC_2692 st077426 47.7 µM -0.127173813205043 0.430315256095877 no 1956 0.449401415553211 2693 25238571
SGTC_1243 0416-0003 5.65 µM -0.127181121678138 0.430312417281272 no 1957 0.449398523378294 2699 2141977
SGTC_1452 4194-0072 190 µM -0.128828069985492 0.429672788800075 no 1958 0.448746846983902 2801 1343545
SGTC_1413 3910-0535 34.4 µM -0.129933910818765 0.429243414729244 no 1959 0.448309357374301 2755 2876951
SGTC_900 1112-0045 141 µM -0.133551326982469 0.42783943765609 no 1960 0.446878687359648 2678 56211 YIL048W NEO1
SGTC_529 4076-0302 30.3 µM -0.133699111279871 0.427782099500872 no 1961 0.44682025397526 2661 5816522
SGTC_1308 1187-1617 41.4 µM -0.133908685651223 0.427700790311925 no 1962 0.446737390995759 2621 2882570
SGTC_2710 st078562 53.7235 µM -0.134421285716302 0.427501928293819 no 1963 0.446534725406882 2619 17250908
SGTC_2588 indole-3-carbinol 100 µM -0.134929167348744 0.427304914944737 no 1964 0.44633393910629 2752 3712 Induces cell cycle arrest.
SGTC_516 3992-2719 87.3 µM -0.136886028597299 0.426545995013334 no 1965 0.445560441219961 2613 5350887 YDR037W KRS1
SGTC_411 enrofloxacin 100 µM -0.139418967928598 0.425564061632248 no 1966 0.444559542248534 2782 71188 A bacterial gyrase inhibitor.
SGTC_2314 7727897 200 µM -0.139623664078034 0.425484728054501 no 1967 0.444478671268311 2678 900724
SGTC_959 1222-0044 107 µM -0.14011514651915 0.425294257749958 no 1968 0.444284506728003 2682 6083612
SGTC_1236 0330-0013 258 µM -0.140251737956201 0.4252413258653 no 1969 0.444230547429757 2702 4617066
SGTC_1587 estradiol valerate 56.1 µM -0.143973456176436 0.423799608118833 no 1970 0.442760715067504 2684 13791 A steroid.
SGTC_1706 st031321 9.9705 µM -0.144780978504895 0.423486924355588 no 1971 0.442441900463296 2764 6103185
SGTC_609 0986-0026 86.3 µM -0.14527696128497 0.423294896864665 no 1972 0.442246101983845 2668 2848610
SGTC_2997 9067075 71.4286 µM -0.145796439586065 0.423093792249894 no 1973 0.442041043334817 2751 27209819
SGTC_3137 9097352 49.47 µM -0.146651583903413 0.422762785573607 no 1974 0.441703517871921 2946 44120435
SGTC_1163 k060-0048 49.9 µM -0.147647234176418 0.422377460991233 no 1975 0.441310588053635 2670 6809982
SGTC_409 arachidonic acid 100 µM -0.147805697332971 0.422316141329959 no 1976 0.441248056453761 2665 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1661 st013063 9.66 µM -0.148014365586136 0.422235396936616 no 1977 0.441165715511341 2671 721395
SGTC_2525 harmine 47.85 µM -0.151383439657259 0.420932184954799 no 1978 0.439836626074254 2761 5280953 A monoamine oxidase inhibitor
SGTC_1979 st071809 45.3 µM -0.151844357976004 0.420753961363001 no 1979 0.439654847573782 2812 4976333
SGTC_475 α-linolenic acid 10 µM -0.15193764104077 0.420717893513477 no 1980 0.439618059834934 2907 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1634 st006576 41 µM -0.152060722229441 0.420670305252936 no 1981 0.439569521504759 2768 3915356
SGTC_993 3909-8757 62.7 µM -0.152344540687169 0.420560573759131 no 1982 0.439457598246378 2730 4288324 YLR208W SEC13
SGTC_2693 st077581 40.7 µM -0.153500328324966 0.420113780459466 no 1983 0.439001865705179 2698 25238761
SGTC_883 0850-0245 24.6 µM -0.15387506308358 0.419968941158974 no 1984 0.438854123341258 2887 6823229 YPR165W RHO1
SGTC_3089 9117425 49.47 µM -0.154410483636292 0.419762013759743 no 1985 0.438643044023628 2754 9401657
SGTC_1055 3448-0672 86 µM -0.154812569830439 0.419606631522627 no 1986 0.43848454069767 2823 748378
SGTC_2373 9071805 200 µM -0.154953399462455 0.419552212265247 no 1987 0.438429027656302 2684 10149009
SGTC_2103 5378138 10 µM -0.154959381486752 0.419549900730956 no 1988 0.438426669654073 2667 244142
SGTC_3006 9075424 71.4286 µM -0.155163697160524 0.419470952085886 no 1989 0.438346133545071 2686 7465181
SGTC_2905 7799065 20.05 µM -0.15619484579999 0.419072560383762 no 1990 0.43793971966492 2784 1296806
SGTC_1808 st050063 61.5 µM -0.156421554935052 0.418984980788222 no 1991 0.437850373958185 2740 4011993
SGTC_1034 k072-0165 12.7 µM -0.156625892687315 0.418906046880769 no 1992 0.437769847492219 2846 5835461
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.157534628992259 0.418555049483863 no 1993 0.437411759305535 2721 676296 Flavone; oxidizing agent.
SGTC_566 0958-0068 16.5 µM -0.157853167162667 0.41843203014911 no 1994 0.437286251231423 2828 6815365
SGTC_1474 0330-0125 5.35 µM -0.157988932379631 0.418379600091845 no 1995 0.437232759933497 2717 X1474
SGTC_1003 4049-0218 100 µM -0.1581138924667 0.418331344060797 no 1996 0.43718352685501 2835 295161
SGTC_1839 st053978 48 µM -0.158158650875138 0.418314059935595 no 1997 0.437165892706973 2683 3788398
SGTC_2486 5283202 22.39 µM -0.159419462620342 0.417827243648645 no 1998 0.436669203022043 2759 1377751
SGTC_2647 atorvastatin 60.16 µM -0.16033859051966 0.41747243536124 no 1999 0.436307180630186 2773 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1997 st073024 93.8 µM -0.161664041544297 0.416960893698207 no 2000 0.435785211337405 2686 686268
SGTC_1084 voriconazole 435 nM -0.161782707217146 0.416915102970913 no 2001 0.435738485638616 2709 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_790 1575-0012 79.1 µM -0.161884774875224 0.416875717989664 no 2002 0.435698296278198 2836 378741 YLR208W SEC13
SGTC_3073 9114972 49.47 µM -0.162383946756756 0.416683113904461 no 2003 0.435501755846461 2779 41905075
SGTC_2164 5685496 200 µM -0.162987012448002 0.416450449360853 no 2004 0.435264330248915 2710 759046
SGTC_2001 4023502 57.655 µM -0.16431413689361 0.415938543976901 no 2005 0.43474192665912 2804 108941 YCR052W RSC6
SGTC_179 1273-0063 6.77 µM -0.164543808044178 0.415849968468658 no 2006 0.434651531426741 2716 3108139
SGTC_1569 carminic acid 40.6 µM -0.165024979320408 0.415664412703387 no 2007 0.434462160474909 2788 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_492 tmb-8 126 µM -0.166072537953893 0.415260504079384 no 2008 0.434049932781129 2735 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1716 st033144 30.6155 µM -0.166856503907966 0.414958287799873 no 2009 0.433741479060781 2788 674617
SGTC_564 3555-0129 330 µM -0.168456123891651 0.414341795859171 no 2010 0.433112229199728 2690 563260
SGTC_2583 asiatic acid 100 µM -0.169165639457143 0.414068416721281 no 2011 0.432833177986602 2844 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_909 3448-9333 149 µM -0.169598586052964 0.413901621139824 no 2012 0.43266291730321 2702 3344074
SGTC_469 w7 172 µM -0.17060169106656 0.413515227928163 no 2013 0.432268484070942 2710 45115570 A P450 inhibitor.
SGTC_2481 5478948 45.16 µM -0.170839370025979 0.413423686922812 no 2014 0.432175035656411 2834 77792
SGTC_1708 st033234 31.827 µM -0.171448366494881 0.413189156099938 no 2015 0.43193561338726 2824 674664
SGTC_3045 9092950 49.47 µM -0.171799156872799 0.413054077161068 no 2016 0.43179771419392 2739 44120432
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.171831805442667 0.4130415056914 no 2017 0.431784880138213 2750 2374 Ca(2+)-ATPase inhibitor.
SGTC_591 4299-0174 154 µM -0.172408381517762 0.412819507343612 no 2018 0.43155824167351 2740 5509088
SGTC_2094 5332512 191.667 µM -0.172553439725479 0.412763660154321 no 2019 0.431501226255191 2850 755774
SGTC_737 1950-0117 57.9 µM -0.174135354992497 0.412154740042156 no 2020 0.43087954419063 2754 5393513
SGTC_12 0849-0099 9.267 µM -0.174163832377972 0.412143780292641 no 2021 0.430868354334039 2689 6071388
SGTC_2563 tomatine 8.54 µM -0.174750442257852 0.411918034044587 no 2022 0.4306378651804 2702 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2334 9017922 200 µM -0.174791270885274 0.411902322966685 no 2023 0.430621823786046 2867 3163164
SGTC_3013 9080133 71.4286 µM -0.174944130500183 0.411843503009745 no 2024 0.430561766909236 2909 17050193
SGTC_335 4077-0256 27.6 µM -0.176828244051545 0.411118664393024 no 2025 0.429821651544184 2815 3121989
SGTC_3032 9089427 49.47 µM -0.178600504550242 0.410437133636912 no 2026 0.42912569914272 2817 17173707
SGTC_1613 st002381 52.1 µM -0.179486662729656 0.410096458782168 no 2027 0.428777794440024 2724 551167
SGTC_784 4579-0127 173 µM -0.179623013539404 0.410044046061611 no 2028 0.428724268170951 2923 1948547
SGTC_2168 5727979 200 µM -0.180776288804739 0.409600795909499 no 2029 0.428271587622267 2681 695210
SGTC_86 0417-1630 471.922 µM -0.181004069054402 0.409513264425304 no 2030 0.428182191064009 2732 3634867
SGTC_1815 st051655 58.2 µM -0.181036134532342 0.409500942652859 no 2031 0.428169606671883 2764 5984156
SGTC_2553 4-methylesculetin 85.09 µM -0.181336096512704 0.409385680862934 no 2032 0.428051887369952 2754 5319502
SGTC_1712 st032288 53.4 µM -0.184979542707064 0.407986297872601 no 2033 0.426622540609191 2779 2883011
SGTC_2725 haloperidol 53.21 µM -0.185643321507757 0.407731478009218 no 2034 0.426362239194164 2738 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_962 1254-0300 21.5 µM -0.187860734069619 0.406880512973175 no 2035 0.425492912157214 2732 7340576
SGTC_3217 9129673 49.47 µM -0.188202069823014 0.406749559233013 no 2036 0.425359124999084 2911 17248312
SGTC_1060 3448-7350 82 µM -0.190027057423725 0.406049578494877 no 2037 0.424643964032276 2852 570178
SGTC_2880 9042983 58.44 µM -0.190199556718721 0.405983431247869 no 2038 0.424576379233991 2884 6464714
SGTC_649 1123-0311 367 µM -0.191692152810259 0.405411186851672 no 2039 0.42399167657443 2831 693629 YIL048W NEO1
SGTC_1733 st037357 54.9 µM -0.192541849532716 0.405085512979767 no 2040 0.423658894962282 2723 1272339 YGL099W LSG1
SGTC_2744 captopril 92.04 µM -0.19261742257948 0.405056550333782 no 2041 0.423629299598982 2822 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2551 apiole 73.87 µM -0.195767158196954 0.403849908659696 no 2042 0.422396208303832 2739 10659 A possible DNA adduct former.
SGTC_3322 9139058 2.11 µM -0.195898010733334 0.4037997996736 no 2043 0.422344997154015 2923 4908926 YPR165W RHO1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.195988690385906 0.403765075514685 no 2044 0.422309509049281 2830 279621
SGTC_1379 2144-0755 36.5 µM -0.196805755781123 0.403452229102518 no 2045 0.421989773373844 2863 5392327
SGTC_2213 7173844 200 µM -0.196942392165993 0.403399918379843 no 2046 0.421936309560556 2772 892728
SGTC_3084 9116877 49.47 µM -0.197998093473529 0.402995805462821 no 2047 0.421523277695406 2733 27241325
SGTC_136 0097-0015 404.482 µM -0.198259301966885 0.402895833182964 no 2048 0.421421095966171 2721 4861337
SGTC_2003 4023581 200 µM -0.19894295732197 0.402634207956724 no 2049 0.421153682996187 2878 16641307
SGTC_816 0325-0417 81.3 µM -0.200127130050779 0.402181145039314 no 2050 0.420690577915489 2816 68101
SGTC_1449 4112-4002 201 µM -0.200594280976651 0.40200244982 no 2051 0.420507915150389 2784 2059539
SGTC_1775 st081588 35.1725 µM -0.202580063824274 0.401243074436743 no 2052 0.419731636833105 2782 1426443 YGL099W LSG1
SGTC_1512 0259-0544 12.2 µM -0.202732990294961 0.401184609856149 no 2053 0.419671868029021 2790 18476
SGTC_1356 1502-0781 85.8 µM -0.203616259874954 0.400846974661304 no 2054 0.419326692894125 2755 567702
SGTC_198 3454-2873 16.191 µM -0.204009379553078 0.400696726060939 no 2055 0.419173084615297 2765 710957
SGTC_2634 4'-methoxyflavone 100 µM -0.204306957398948 0.400583002893263 no 2056 0.419056816711713 2836 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_890 0929-0006 47.2 µM -0.204495553460463 0.400510932865898 no 2057 0.418983133202689 2784 1378169
SGTC_65 0798-0905 34.986 µM -0.205172441042991 0.400252295211679 no 2058 0.418718700133689 3174 3602145
SGTC_2249 haloperidol 116.36 µM -0.205556124414209 0.40010570982978 no 2059 0.418568826593225 2753 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_917 harmaline 728.087 nM -0.207570583714826 0.399336321485169 no 2060 0.41778213743767 2892 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2956 9076196 2.52 µM -0.208043369097597 0.399155805693505 no 2061 0.417597552239153 2882 16423868
SGTC_1729 st035615 45.989 µM -0.208367211713257 0.399032170686057 no 2062 0.417471127853853 2897 17385451
SGTC_1176 0848-0131 83.3 µM -0.209451159724743 0.398618420212316 no 2063 0.417048029309621 2882 6769040
SGTC_2007 4011539 71.82 µM -0.211047994883229 0.398009104805987 no 2064 0.416424910101194 2769 45595301
SGTC_3098 9119039 49.47 µM -0.211875613127817 0.39769340254314 no 2065 0.416102038287424 2761 17161528
SGTC_2347 9049783 174.81 µM -0.212734813729467 0.397365723785839 no 2066 0.415766905407523 2941 6467988 YPL169C MEX67
SGTC_2847 9005661 71.43 µM -0.213041232993178 0.397248880244212 no 2067 0.415647400777591 2788 2991449
SGTC_3176 9106582 49.47 µM -0.213304786622828 0.397148389566594 no 2068 0.415544620141199 2812 17018027
SGTC_1333 1482-0047 286 µM -0.213730156025549 0.396986214365376 no 2069 0.415378746785685 2892 3811116
SGTC_2173 5763948 167 µM -0.214524766571609 0.396683311009885 no 2070 0.41506892778063 2762 2867177
SGTC_2224 6650123 117.647 µM -0.215215187454655 0.396420175069747 no 2071 0.414799775240813 2780 2908370
SGTC_1931 st074438 57.1 µM -0.215749948091133 0.396216397391082 no 2072 0.414591332511229 2727 2787313
SGTC_3265 9137266 49.47 µM -0.216958405408802 0.395756003110616 no 2073 0.414120380253626 2755 17224265
SGTC_612 0302-0167 22.4 µM -0.221768473373911 0.39392492566593 no 2074 0.412247061478614 2866 235821
SGTC_741 4582-0002 126 µM -0.222127748844466 0.393788251639845 no 2075 0.412107218473497 2794 2912688
SGTC_2717 st081029 62.2815 µM -0.222314832273022 0.393717087346983 no 2076 0.412034403255353 2891 5292846
SGTC_3303 9125618 40.5795 µM -0.222981259193348 0.393463615395896 no 2077 0.411775046159709 2891 22695467
SGTC_2326 6164455 177.58 µM -0.224151631330595 0.393018579866129 no 2078 0.411319659218361 2878 2888790
SGTC_660 4031-1742 102 µM -0.225886111596218 0.392359298727503 no 2079 0.410645000007678 2792 6738706
SGTC_3075 9116269 49.47 µM -0.228477484370586 0.3913748860486 no 2080 0.409637529057576 3009 17015205 YNL244C SUI1
SGTC_360 0957-0399 1.01 µM -0.228520378065847 0.39135859739159 no 2081 0.409620857894958 2967 6752301 YPR165W RHO1
SGTC_1334 1486-0610 236 µM -0.229157321034538 0.391116744055952 no 2082 0.409373321415793 2903 3742339
SGTC_338 4055-0136 114 µM -0.229685731803755 0.390916133379656 no 2083 0.409167991446663 2818 2900563
SGTC_132 0417-1715 25.805 µM -0.230154835515176 0.39073806289399 no 2084 0.408985727905733 2894 6769098
SGTC_1088 bifonazole 369 nM -0.230865086621749 0.390468497131235 no 2085 0.408709807454347 2789 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_53 0973-0023 39.979 µM -0.233614301629696 0.38942556880018 no 2086 0.407642211925641 2792 674768
SGTC_1437 4092-1038 11.6 µM -0.233756522339572 0.389371638257663 no 2087 0.407587002307712 2842 3977136
SGTC_421 streptovitacin 30 mM -0.237898036962187 0.387802101298136 no 2088 0.405980089044798 3026 91467 include heat shock
SGTC_3261 9137475 49.47 µM -0.23848143979619 0.387581151876539 no 2089 0.405753854517447 2800 17027690
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.239369266808473 0.387244979184514 no 2090 0.405409629456072 2923 616764
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.239469387981248 0.387207073941471 no 2091 0.405370815423735 2762 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1175 0741-0056 27.6 µM -0.240142756013601 0.386952169018175 no 2092 0.405109794647522 3036 765927
SGTC_1737 st035557 69.7 µM -0.240297593472916 0.386893561853446 no 2093 0.40504978024852 2756 5716916
SGTC_1562 morin hydrate 59.1 µM -0.240342986234368 0.38687638083422 no 2094 0.405032186613346 3011 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3298 9116858 71.43 µM -0.240640469670809 0.386763789765684 no 2095 0.404916890712413 2973 2506942
SGTC_1879 gemcitabine 100 µM -0.241683818950549 0.386368979934324 no 2096 0.404512584269296 2846 60750 A nucleoside analog which inhibits DNA replication.
SGTC_882 0843-0131 351 µM -0.241973503245381 0.386259382446009 no 2097 0.404400347280821 2822 5425421
SGTC_2288 7946289 167.31 µM -0.242483577347764 0.386066426008234 no 2098 0.40420274029507 3015 1246052
SGTC_886 0866-0150 153 µM -0.24287618489186 0.385917925301289 no 2099 0.404050657481928 3026 271463
SGTC_1986 st071812 45 µM -0.24372605594189 0.385596525561755 no 2100 0.403721496034188 2855 11838594
SGTC_2469 5655019 90.81 µM -0.244303133349567 0.385378334234116 no 2101 0.403498028463603 2966 2788239
SGTC_1466 k213-0079 57.5 µM -0.244858606235631 0.385168345776465 no 2102 0.40328295678709 2834 3657981
SGTC_2776 terbinafine 19.92 µM -0.245038444107918 0.385100367892154 no 2103 0.403213332231799 2843 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2122 5258151 111.688 µM -0.249401834004423 0.383452113477287 no 2104 0.401524983317045 2864 2173356
SGTC_3157 9099274 49.47 µM -0.251083334935532 0.382817493510333 no 2105 0.400874840039404 2951 17217662
SGTC_3230 9131665 49.47 µM -0.251254977008347 0.382752731255835 no 2106 0.40080849096372 2840 15943720
SGTC_187 1488-2104 32.728 µM -0.252942772667176 0.382116084100441 no 2107 0.400156218054398 2915 2852859
SGTC_1571 st070080 73.4 µM -0.253226673289673 0.382009026254112 no 2108 0.400046527881541 2995 4315245
SGTC_3355 9151058 44.0485 µM -0.253295725036016 0.381982988466563 no 2109 0.400019849674414 2833 17015728
SGTC_1689 st020265 53.493 µM -0.253652263824684 0.381848554581352 no 2110 0.399882108005429 2980 5758320 YPR016C TIF6
SGTC_855 0428-0020 25 µM -0.253694065185867 0.381832794201291 no 2111 0.39986595969652 2875 6812414
SGTC_2464 5717415 7.67 µM -0.255071303720105 0.381313643208917 no 2112 0.399334013777069 2857 5285744
SGTC_1256 0570-0116 285 µM -0.255626481390288 0.381104428936704 no 2113 0.399119634211394 2874 410638
SGTC_135 0933-0004 26.348 µM -0.25564194506271 0.381098602072355 no 2114 0.399113663413317 2976 21230617 YGL099W LSG1
SGTC_128 0906-2981 13.371 µM -0.255689388979212 0.381080724904734 no 2115 0.399095344623331 3023 6740226
SGTC_3241 9133421 49.47 µM -0.257243326107854 0.380495332075538 no 2116 0.39849546983407 2895 17018221
SGTC_1498 4478-3555 97.6 µM -0.258284272928164 0.38010334376341 no 2117 0.398093761487772 2870 3437919
SGTC_1438 4092-1045 4 µM -0.258730379993844 0.379935391334107 no 2118 0.397921638817661 2864 1351342
SGTC_2456 5770359 74.46 µM -0.2591021851219 0.379795429736332 no 2119 0.397778199437444 3012 3118787
SGTC_2245 6637752 200 µM -0.260109586455793 0.379416284715391 no 2120 0.397389621726957 3017 681890
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.26325923603434 0.37823163369728 no 2121 0.396175388342992 2987 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3237 9133362 49.47 µM -0.263874497130434 0.378000353945033 no 2122 0.395938313844885 2989 43845137
SGTC_3214 9129694 49.47 µM -0.263977575051056 0.377961610707693 no 2123 0.395898599271694 3025 17158655
SGTC_1987 st072290 61.9 µM -0.264146340233734 0.377898180670223 no 2124 0.395833578589682 2925 54697379
SGTC_1302 1159-0335 255 µM -0.2643341276451 0.377827605037566 no 2125 0.395761232562012 2864 649284
SGTC_3105 9121040 49.47 µM -0.264819383020258 0.377645251716984 no 2126 0.395574302167254 2796 41448907
SGTC_1640 st009078 66.4 µM -0.26546154075967 0.377403978238469 no 2127 0.395326966672816 3006 690618
SGTC_2930 9013230 14.89 µM -0.265718890728704 0.377307299340223 no 2128 0.395227856777452 3019 2995857
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.266208113504666 0.377123533778738 no 2129 0.39503946737212 2912 4330530
SGTC_872 0588-0139 234 µM -0.267829924421712 0.37651453611925 no 2130 0.394415117789101 2875 2047100
SGTC_885 0865-0106 16.8 µM -0.268069205914712 0.376424710760415 no 2131 0.394323024356477 2881 2793380
SGTC_2240 6690706 185.951 µM -0.270293707073651 0.37558996239403 no 2132 0.393467153138508 2804 805876
SGTC_730 1436-0052 41.2 µM -0.270949167352803 0.375344110497614 no 2133 0.393215064397048 2880 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_597 k018-0003 82.8 µM -0.270973236046895 0.37533508370669 no 2134 0.393205808475851 2999 6786234
SGTC_2491 paeonol 100 µM -0.271247019865739 0.375232407856593 no 2135 0.393100525690291 2827 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1681 tripelennamine 100 µM -0.27361048165372 0.3743464181901 no 2136 0.392191989046193 2868 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2434 5670830 169.91 µM -0.273842713418539 0.374259397297886 no 2137 0.392102748615221 2983 1549830
SGTC_2644 guaiazulene 100 µM -0.275159294411848 0.373766174930215 no 2138 0.391596929311532 2980 3515 A coloring agent.
SGTC_2947 9072639 7.68 µM -0.275289158196403 0.373717536070235 no 2139 0.391547046655453 2974 16488146
SGTC_916 4466-0038 42 nM -0.275466919697302 0.37365096097904 no 2140 0.391478768648876 3083 5722064 YGL116W CDC20
SGTC_2923 7992654 58.14 µM -0.275607006347191 0.37359849849822 no 2141 0.391424963868598 2933 2985126
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.275879103637431 0.373496604697902 no 2142 0.391320462095908 2892 165521
SGTC_1497 4476-2978 41.3 µM -0.276406025189313 0.373299310575773 no 2143 0.39111811474538 2971 1528379
SGTC_1253 0550-0034 176 µM -0.276711015773272 0.373185128768638 no 2144 0.391001006338604 3015 5969915
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.276966213121247 0.373089597017535 no 2145 0.390903024825946 2899 1377
SGTC_1927 st060202 13.8 µM -0.278166190569079 0.372640496618878 no 2146 0.390442393518841 2856 688887
SGTC_562 3772-2733 112 µM -0.278401196802142 0.372552564054146 no 2147 0.390352200448823 3011 2876874 YIL048W NEO1
SGTC_1039 k821-0043 94 µM -0.279418129935525 0.372172133577068 no 2148 0.389961979633552 3044 15992768
SGTC_889 0919-1524 82.7 µM -0.280551162027024 0.371748417870965 no 2149 0.389527339546951 2962 3905452
SGTC_1521 st012942 49.4 µM -0.280935860559641 0.371604588915391 no 2150 0.389379797529846 3115 24207259
SGTC_521 r062-0005 13.8 µM -0.28196731442528 0.371219043156667 no 2151 0.388984286555865 2881 2832033
SGTC_932 2857-0803 154 µM -0.282708194375759 0.370942190340183 no 2152 0.388700267099543 3134 674898
SGTC_1553 gossypol 38.6 µM -0.284152109696851 0.370402818557317 no 2153 0.388146907125607 2885 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_426 0988-0037 14.6 µM -0.28480743159027 0.370158108287364 no 2154 0.387895839171584 3104 5383008
SGTC_155 k072-0202 43.6 µM -0.287362045489571 0.369204667019745 no 2155 0.386917559732944 2862 5857737
SGTC_262 fenpropimorph 62.5 µM -0.287522759572011 0.369144711612802 no 2156 0.386856038842498 2888 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1756 st041558 35.5 µM -0.287537933040736 0.36913905121857 no 2157 0.386850230628972 3107 3955792
SGTC_1457 k015-0032 57.3 µM -0.287984702066763 0.368972398766506 no 2158 0.386679224412069 2881 4302660
SGTC_2740 felodipine 17.08 µM -0.2885862380158 0.368748054527794 no 2159 0.386449014052873 3011 3333 L-type calcium channel blocker
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.289115513731342 0.368550696893711 no 2160 0.386246491036876 3162 6710655
SGTC_1208 2323-2347 50.3 µM -0.289138816853556 0.368542008364482 no 2161 0.386237574999922 3071 5412760
SGTC_1230 0170-0365 3.77 µM -0.29046344969354 0.36804823189531 no 2162 0.385730854459387 3021 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_752 1896-0090 130 µM -0.291050802104343 0.36782935729364 no 2163 0.385506232996258 2921 772567
SGTC_1068 loratadine 26.9 µM -0.291999341372418 0.367475978440279 no 2164 0.385143563773246 2961 3957 A H1 histamine antagonist.
SGTC_2941 9056145 11.23 µM -0.293607435061187 0.366877138668489 no 2165 0.384528946860012 2917 2119517
SGTC_2942 9052777 62.25 µM -0.293777231568494 0.36681392683639 no 2166 0.384464067173591 2957 6469503
SGTC_2872 9044037 25.97 µM -0.295113505799605 0.366316584929104 no 2167 0.383953586409118 2908 6465195
SGTC_534 k292-0788 63.4 µM -0.29708269718949 0.365584089714533 no 2168 0.383201686998883 3096 4146317
SGTC_2189 6047310 154.431 µM -0.297861238157522 0.365294624844093 no 2169 0.382904536639214 2899 711535
SGTC_2760 etidronate 98.04 µM -0.299475987456337 0.364694498877481 no 2170 0.382288445510768 2957 3305 A chelator and antioxidant.
SGTC_1829 berberine 14.4 µM -0.30039477169413 0.364353178049289 no 2171 0.381938025616166 3110 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_309 k408-0051 1.48 µM -0.301345573855873 0.3640000760461 no 2172 0.381575496057835 2977 3640463
SGTC_2384 9036245 200 µM -0.302430260986794 0.363597393788946 no 2173 0.381162044593177 2984 6462766
SGTC_1608 st001473 40.5 µM -0.302705216975864 0.363495342281363 no 2174 0.381057260823467 2937 7292267
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.303865998223379 0.363064618439121 no 2175 0.380614991563266 2952 2724 A muscle relaxant with antifungal properties.
SGTC_2143 5623677 140.463 µM -0.304273127261764 0.362913588596332 no 2176 0.380459908247457 2951 5375313
SGTC_1636 st007707 68.9 µM -0.30458337550722 0.362798512263035 no 2177 0.380341741593252 3149 403051
SGTC_3023 9089636 49.47 µM -0.30496269222878 0.362657834096129 no 2178 0.380197283465342 3026 17249241
SGTC_914 3820-6779 408 µM -0.30512350929282 0.362598197053128 no 2179 0.380136043298822 2901 2893481
SGTC_1222 0366-0074 1.18 µM -0.305147451217033 0.362589318768146 no 2180 0.380126926317905 3061 286520
SGTC_1216 1165-0504 9.65 µM -0.305212146566773 0.362565328428094 no 2181 0.380102290942451 3066 6304004
SGTC_336 4111-0029 111 µM -0.305992864672748 0.36227586498371 no 2182 0.379805039275673 2976 3131175
SGTC_725 1497-0963 19 µM -0.306941662972566 0.36192418917242 no 2183 0.379443888122617 3072 3549977
SGTC_3232 9132874 49.47 µM -0.30833853093134 0.361406646767143 no 2184 0.378912374931756 2948 3784940
SGTC_2984 9022109 38.96 µM -0.308945283028444 0.361181922802337 no 2185 0.378681574861177 3057 6459207
SGTC_162 k030-0015 37.8 µM -0.309159347307957 0.361102650821366 no 2186 0.378600158101896 3037 1809920 YMR134W ERG29
SGTC_523 1934-0222 13.7 µM -0.310479396394905 0.360613944033443 no 2187 0.37809821258509 2960 1361595
SGTC_1933 st074711 15.9 µM -0.3108024916348 0.360494362786462 no 2188 0.377975387692331 2917 17250958
SGTC_700 3453-2283 142 µM -0.311087306419329 0.360388960887712 no 2189 0.377867125370409 3139 565664
SGTC_1197 1601-0112 267 µM -0.31126973669335 0.360321454174724 no 2190 0.377797785957785 2946 7350313
SGTC_571 k831-0106 44.2 µM -0.311872336299026 0.360098498465488 no 2191 0.377568773553317 3063 4783639
SGTC_585 0kpi-0023 191 µM -0.311938255918825 0.360074111764183 no 2192 0.377543724021743 3085 64601
SGTC_1299 1079-1439 3.74 µM -0.312420454798312 0.359895741529289 no 2193 0.377360503562135 2983 323161
SGTC_2996 9066192 71.4286 µM -0.313725022545654 0.359413321755816 no 2194 0.376864947163091 3003 6472854
SGTC_815 1582-0027 36.9 µM -0.313936047632087 0.359335307223945 no 2195 0.376784805674317 3047 3128206
SGTC_2058 5236698 133 µM -0.31401093184617 0.359307624451356 no 2196 0.376756367997943 2987 766665
SGTC_74 000s-0487 160.283 µM -0.315167415459355 0.358880195986795 no 2197 0.376317272223303 2932 677548
SGTC_304 1310-0298 97 µM -0.316569915158682 0.358362078684221 no 2198 0.375784983364765 3016 1550234
SGTC_1265 0819-1001 68.8 µM -0.316648832756753 0.35833293235257 no 2199 0.375755038885842 2971 3106768
SGTC_2990 9074105 71.4286 µM -0.316797254237033 0.358278118656583 no 2200 0.37569872389376 3049 6502001
SGTC_2207 7258803 200 µM -0.317832401372775 0.357895908627872 no 2201 0.375306035686041 3043 3666799
SGTC_82 0054-0107 293.755 µM -0.319233007026232 0.357378986173205 no 2202 0.374774914677558 3026 3104697
SGTC_2913 7966556 36.57 µM -0.320859814962348 0.356778907493492 no 2203 0.374158314028799 3099 2976516
SGTC_2255 7941087 197.44 µM -0.321660739685699 0.356483601399941 no 2204 0.373854861761424 3116 935561
SGTC_2208 7283366 200 µM -0.323079631558753 0.355960658124534 no 2205 0.373317467725447 3058 898663
SGTC_2828 7998861 71.43 µM -0.323449417569791 0.355824415164965 no 2206 0.373177454627492 3088 2988188
SGTC_2149 5554786 194.827 µM -0.323812696133362 0.355690587720946 no 2207 0.373039921768352 2993 745063 YPR165W RHO1
SGTC_2570 licareol 100 µM -0.324746947533288 0.355346502484 no 2208 0.372686299855478 3046 443158
SGTC_1432 4049-0298 68.4 µM -0.326243777407931 0.354795465157704 no 2209 0.372119961046466 3082 741646
SGTC_1406 3909-7906 11.9 µM -0.326474468129044 0.354710566519958 no 2210 0.372032701735608 3015 X1406
SGTC_2507 purpurin 79.67 µM -0.328194541897069 0.35407777391722 no 2211 0.371382287220676 2959 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1864 st057645 30.4 µM -0.330338207869739 0.353289711194917 no 2212 0.370572213029925 3052 688666
SGTC_621 3584-0052 32.1 µM -0.330352793415304 0.3532843513501 no 2213 0.370566703229509 3098 2273927
SGTC_2666 tannic acid 100 µM -0.330490980230357 0.353233572390939 no 2214 0.370514503429877 3067 16134267 A thiamine antagonist.
SGTC_1182 1222-0449 220 µM -0.331444432465224 0.352883282343938 no 2215 0.370154403725035 3055 658318
SGTC_1059 3448-6867 171 µM -0.331789964987149 0.352756367464564 no 2216 0.370023931124396 2989 3934407
SGTC_1770 st043884 66.3 µM -0.332318248613933 0.352562359368655 no 2217 0.36982448088015 2960 670149
SGTC_2367 9070478 135.38 µM -0.333428538837506 0.35215473886405 no 2218 0.369405411791459 2949 572802
SGTC_176 1486-1328 72.834 µM -0.33601118419955 0.351207230622807 no 2219 0.368431216280037 3063 22310231
SGTC_27 0485-0001 32.618 µM -0.33788361125488 0.350520861266039 no 2220 0.367725449162135 3006 2054479
SGTC_2651 TUB2.036 5 µM -0.339754508959333 0.349835539603032 no 2221 0.367020704320556 3158 15992207 YFL037W TUB2
SGTC_935 2996-0153 430 µM -0.340218084893493 0.349665804305101 no 2222 0.366846149942156 3144 23738523
SGTC_1784 st039334 36.3 µM -0.341586468645424 0.34916495489671 no 2223 0.366331060893386 3236 3496984
SGTC_2315 7733312 200 µM -0.343642133879689 0.348413043698926 no 2224 0.365557717007693 3004 726316
SGTC_598 3937-0236 20.2 µM -0.344155402085196 0.348225395717389 no 2225 0.365364709941215 3075 1379313
SGTC_43 0570-0105 72.5 µM -0.344859578833143 0.347968013093056 no 2226 0.365099969962955 3005 1114046 YDL195W SEC31
SGTC_400 oxethazaine 37.5 µM -0.345033296076078 0.34790452871936 no 2227 0.365034669679301 3079 4621 A local anesthetic.
SGTC_1548 st061468 90.8 µM -0.345213795095071 0.347838570484994 no 2228 0.364966824273183 3121 390799
SGTC_2473 5854593 8.94 µM -0.345478188059887 0.347741963905968 no 2229 0.364867452705156 2949 2872951
SGTC_2221 6807166 181.081 µM -0.345740301155427 0.347646200126145 no 2230 0.36476894698075 3073 674925
SGTC_2031 5180455 200 µM -0.346388385509984 0.34740946236944 no 2231 0.364525426255907 3009 29949
SGTC_2 0422-0095 29 µM -0.346454145269682 0.347385444410072 no 2232 0.364500719771974 3061 6790840
SGTC_697 0508-1955 564 µM -0.346549565942131 0.347350594249663 no 2233 0.364464870439539 3166 6243113
SGTC_2628 lathosterol 100 µM -0.346718709814063 0.347288821592846 no 2234 0.364401326379833 3196 6710616
SGTC_2854 9024559 71.43 µM -0.349607534762779 0.346234427728149 no 2235 0.36331662772746 3098 3163529
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.350834711737051 0.345786879561592 no 2236 0.362856177087613 2956 88881 An O-methylated flavonoid and antioxidant.
SGTC_106 0092-0003 11.579 µM -0.351252894212983 0.345634418705421 no 2237 0.362699315553612 3069 1072148
SGTC_273 hydroxyurea 18.1 mM -0.352060598923752 0.345340016825237 no 2238 0.362396408276051 3009 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1540 guanosine 70.6 µM -0.353866173763105 0.34468223782615 no 2239 0.361719589153365 3031 6802 Guanosine is a purine nucleoside
SGTC_803 4488-1585 147 µM -0.354987201749502 0.344274078305101 no 2240 0.36129958959035 3155 747204
SGTC_2275 7947463 200 µM -0.355331467396459 0.344148769630004 no 2241 0.361170642009098 3172 1225414
SGTC_1401 3807-4679 7.6 µM -0.355848023686172 0.343960781274774 no 2242 0.360977191117682 3073 3291456
SGTC_788 1182-0090 188 µM -0.355902401021605 0.343940994181749 no 2243 0.360956828814213 3216 5715185
SGTC_3331 9141060 1.957 µM -0.356315815776017 0.343790572761743 no 2244 0.360802033150426 3029 4906567 YPR165W RHO1
SGTC_1967 st070177 51.4 µM -0.357244323832757 0.343452824224852 no 2245 0.36045445327906 3179 5729214
SGTC_2616 abietic acid 100 µM -0.359805840759488 0.34252171073861 no 2246 0.359496167517981 3202 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_785 1270-0111 65.3 µM -0.359920455543007 0.342480070479563 no 2247 0.359453309723903 3000 6741994
SGTC_2748 diazoxide 86.69 µM -0.359943405658703 0.342471732790764 no 2248 0.359444728221983 3097 3019 A potassium channel activatior.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.360260851574877 0.342356413785703 no 2249 0.359326036192293 3099 1241132 A phosphatase inhibitor.
SGTC_3094 9117742 49.47 µM -0.361164094487026 0.342028371947953 no 2250 0.358988390797792 2980 17149698
SGTC_2765 myclobutanil 7.74 µM -0.361591890970851 0.341873045420885 no 2251 0.358828512640091 3134 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1344 1488-0097 29.1 µM -0.361614142160575 0.341864967077532 no 2252 0.3588201974949 3138 747966
SGTC_302 1094-0063 18.9 µM -0.36271944995728 0.341463773846291 no 2253 0.358407234432074 3024 5440289
SGTC_2805 7950783 58.44 µM -0.36422125242712 0.340918952068973 no 2254 0.357846399092896 3152 1178958 YDL195W SEC31
SGTC_160 3453-0671 289.699 µM -0.365582597493535 0.340425371702152 no 2255 0.357338281348091 3039 5322268
SGTC_384 k007-0144 5.16 µM -0.366407307967853 0.340126490780358 no 2256 0.357030583689146 3096 6824886
SGTC_2572 astragaloside iv 100 µM -0.366529003827083 0.34008239583719 no 2257 0.356985187099394 3207 45006101 An anti-inflammatory agent.
SGTC_1181 1222-0449 220 µM -0.366685948553834 0.340025532145598 no 2258 0.356926644503188 3226 658318
SGTC_1121 fusaric acid 630.51 nM -0.366726134814463 0.340010972578383 no 2259 0.356911655003007 3054 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2248 tofa 1.1 µM -0.366870940265675 0.339958511236193 no 2260 0.35685764431202 2987 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1988 st071872 53.4 µM -0.367530077277447 0.339719752681618 no 2261 0.356611830407045 3180 16414116
SGTC_420 mitomycin C 81.9 mM -0.367989500975556 0.339553374103613 no 2262 0.356440531384061 3044 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2721 ifenprodil 61.44 µM -0.368626528403769 0.339322728731059 no 2263 0.356203059610463 3188 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_576 1073-0113 22.7 µM -0.369391860466669 0.339045708325266 no 2264 0.35591783203794 3157 5439563
SGTC_508 roscovitine 141 µM -0.369963087382892 0.338839003116088 no 2265 0.355704997026825 3033 160355 A CDKinase inhibitor.
SGTC_2593 nobiletin 86.24 µM -0.373459834898727 0.337574723307999 no 2266 0.354403116761028 3114 72344 An anti-infammatory.
SGTC_1935 st074532 41.6 µM -0.373611525161262 0.33751991969877 no 2267 0.354346679042163 3161 2829742
SGTC_3195 9113082 49.47 µM -0.375891794086757 0.336696505663935 no 2268 0.353498670641533 3167 17018038
SGTC_2912 7964298 10.93 µM -0.376383246108883 0.336519142747643 no 2269 0.353315999762072 3150 2975850
SGTC_282 k297-0036 65.7 µM -0.376520959066863 0.336469449256071 no 2270 0.353264818428974 3183 5061378
SGTC_1232 0279-0259 161 µM -0.378936388296918 0.335598310705183 no 2271 0.352367550898151 3107 1560000
SGTC_751 0833-0568 350 µM -0.37955757944468 0.335374417058761 no 2272 0.352136927479818 3161 6954252
SGTC_480 am 92016 50 µM -0.380446745365445 0.335054039983502 no 2273 0.351806910379415 3142 2129 K+ channel blocker.
SGTC_2156 5649887 115 µM -0.380528340291268 0.335024646366097 no 2274 0.3517766317199 3175 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1736 st036774 51 µM -0.382024913598348 0.33448570272313 no 2275 0.351221442625864 3293 1272247
SGTC_1998 st075797 76.8 µM -0.383047863563768 0.334117515649197 no 2276 0.350842137773948 3196 24208315
SGTC_2008 4012253 172 µM -0.383853297561852 0.333827730659506 no 2277 0.350543591324559 3063 603940
SGTC_1867 st057372 64 µM -0.384594025850464 0.333561313418069 no 2278 0.350269110497367 3145 688837
SGTC_2466 5983409 37.09 µM -0.384824812785713 0.333478323576754 no 2279 0.350183607133135 3104 2879657
SGTC_1877 wortmannin 25 µM -0.38683368284983 0.332756288395219 no 2280 0.349439669722897 3212 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2051 5263410 176 µM -0.389046266995027 0.331961750878654 no 2281 0.348620960493684 3199 227584
SGTC_2185 6113692 200 µM -0.389895695972388 0.331656921860357 no 2282 0.348306838334897 3213 874150
SGTC_3212 9128307 49.47 µM -0.392860400800148 0.330593871990111 no 2283 0.347211295211293 3002 27243542
SGTC_2752 diclazuril 33.15 µM -0.393911445799625 0.330217327653114 no 2284 0.346823209829573 3203 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1297 1068-0111 14.1 µM -0.395274812759916 0.329729147873229 no 2285 0.346320042811996 3086 767057
SGTC_2305 7443522 69.23 µM -0.395404613765156 0.329682685228377 no 2286 0.346272152306458 3080 5415886
SGTC_2971 9092186 9.93 µM -0.399183605793548 0.328331138842485 no 2287 0.34487896106094 3053 25236400
SGTC_2921 7974240 10.71 µM -0.399331988707696 0.328278115757341 no 2288 0.344824299853951 3208 2979074 YDR527W RBA50
SGTC_2101 5377231 179.231 µM -0.399383764717704 0.328259614954793 no 2289 0.344805227401296 3213 2844213
SGTC_1738 st035555 74 µM -0.402531730158602 0.327135564648653 no 2290 0.343646370701997 3211 5331140
SGTC_1455 4262-0120 131 µM -0.403320231526038 0.326854257764744 no 2291 0.343356330102136 3275 1529587
SGTC_2359 9039622 200 µM -0.408650754107662 0.324955120148004 no 2292 0.341397989179944 3075 6463596
SGTC_3144 9087057 49.47 µM -0.408785015663713 0.324907344380657 no 2293 0.341348718650625 3238 17249618
SGTC_142 0335-0849 62.6745 µM -0.411618290202951 0.323899821689617 no 2294 0.340309611729734 3280 3889043 YPR107C YTH1
SGTC_2110 5483698 200 µM -0.412034168069758 0.323752042314997 no 2295 0.340157189778925 3140 2848765 YHR062C RPP1
SGTC_2722 naftopidil 47.16 µM -0.412073453519765 0.323738083933098 no 2296 0.340142792754952 3236 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_16 erodoxin 22.806 µM -0.4180084240785 0.321632206934874 no 2297 0.33797047903713 3262 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2792 7535235 81.82 µM -0.419268332245262 0.321185893335669 no 2298 0.337510018811337 3176 1281891
SGTC_3106 9121286 49.47 µM -0.41969127419515 0.321036126968965 no 2299 0.337355500170254 3328 15943471
SGTC_2521 angolensin 13.4 µM -0.421327996281474 0.320456827996721 no 2300 0.336757794769852 3267 821428 A flavenoid.
SGTC_776 4476-4378 112 µM -0.422426022201958 0.320068439251867 no 2301 0.336357043664849 3221 2892008
SGTC_1066 ketoconazole 628 nM -0.423479924278605 0.319695843151918 no 2302 0.335972571405738 3279 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2867 9039098 71.43 µM -0.424218985650155 0.319434664178068 no 2303 0.33570305797304 3111 6463460
SGTC_829 1635-0120 117 µM -0.424809907772918 0.319225900969461 no 2304 0.33548762723991 3272 285054
SGTC_1005 4092-0690 4.4 µM -0.427573540653118 0.318250315871804 no 2305 0.334480816563395 3166 1529343
SGTC_1856 st057054 55.7 µM -0.427874841857237 0.318144030088363 no 2306 0.334371122207636 3346 1266018
SGTC_3235 9132602 49.47 µM -0.428908158883269 0.317779635162212 no 2307 0.333995031216394 3284 4912240
SGTC_2531 methyl deoxycholate 70.07 µM -0.429054703905258 0.31772797094891 no 2308 0.33394170747666 3119 16667744 Haematoxylin.
SGTC_2879 9041815 71.43 µM -0.429280526682386 0.317648364437754 no 2309 0.33385954328655 3231 4942971
SGTC_2066 5222451 176 µM -0.429494249972148 0.317573030973784 no 2310 0.333781788754418 3160 2281147
SGTC_1822 st052468 42 µM -0.430009241839158 0.317391537002866 no 2311 0.333594459219542 3209 2873678
SGTC_507 nimesulide 162 µM -0.432887628330764 0.316377942323011 no 2312 0.332548204136707 3344 4495 A COX2 inhibitor.
SGTC_1185 1319-0113 81.3 µM -0.432911159971727 0.31636966156205 no 2313 0.332539656058697 3258 4672763
SGTC_3188 9110789 49.47 µM -0.433427433107909 0.316188008736088 no 2314 0.332352137166792 3318 849217
SGTC_1164 k060-0068 93.7 µM -0.433746977568354 0.316075597923919 no 2315 0.332236094382701 3150 5963676
SGTC_1458 k015-0034 6.33 µM -0.434850294703671 0.315687598716875 no 2316 0.331835547719701 3217 3598957
SGTC_2259 7964009 200 µM -0.436301976804412 0.315177400738305 no 2317 0.331308823903543 3296 313134
SGTC_2887 9044784 58.44 µM -0.436518494450279 0.315101335140764 no 2318 0.331230291873499 3174 6465546
SGTC_1042 0350-0096 82 µM -0.437597122781455 0.314722515179717 no 2319 0.330839178641987 3157 3122515
SGTC_1246 0422-0085 105 µM -0.437618675292147 0.314714947809149 no 2320 0.330831365529226 3309 264295
SGTC_1798 st045719 60.953 µM -0.43808824445632 0.314550095207367 no 2321 0.330661157866752 3259 3980186
SGTC_559 1550-0661 158 µM -0.439307596589125 0.314122187461351 no 2322 0.330219335267645 3251 5830875
SGTC_2028 5153890 36.43 µM -0.439944100278462 0.313898918133149 no 2323 0.329988797148621 3187 2830968 YPR165W RHO1
SGTC_1699 st031318 29.054 µM -0.440041886640678 0.31386462319534 no 2324 0.32995338518668 3270 5340658
SGTC_2154 5570129 200 µM -0.440048179611431 0.313862416224439 no 2325 0.329951106327614 3264 673366
SGTC_1097 itavastatin 7.23 µM -0.440763310348071 0.313611660306984 no 2326 0.329692178798043 3197 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2918 7977171 22.06 µM -0.441276489417462 0.313431770473138 no 2327 0.32950642223246 3206 2236483
SGTC_1619 st003326 88.7 µM -0.442648102277306 0.312951183059497 no 2328 0.329010143035931 3320 2849032
SGTC_146 3448-8650 53.125 µM -0.444797320774375 0.31219877627343 no 2329 0.328233115370506 3189 2891488 YIL048W NEO1
SGTC_1212 0520-0165 585 µM -0.446681580498959 0.311539770918945 no 2330 0.327552491507603 3530 5403258
SGTC_1072 oxiconazole 14.9 nM -0.447979569812193 0.311086159889688 no 2331 0.327083970588047 3282 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1149 3909-7961 23.3 µM -0.448831116184834 0.310788723959867 no 2332 0.326776745174143 3223 735261
SGTC_3296 9122258 64.045 µM -0.450136162798503 0.310333125211495 no 2333 0.32630613143186 3270 4730474
SGTC_2021 4019055 173 µM -0.450904528088348 0.310065020782563 no 2334 0.326029179928081 3344 44827708 YER133W GLC7
SGTC_2827 7993847 71.43 µM -0.452775248959728 0.309412695534491 no 2335 0.325355294009312 3265 2985692
SGTC_457 grayanotoxin iii 135 µM -0.453626895430426 0.309115922849073 no 2336 0.325048696041865 3291 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_655 k060-0012 42 µM -0.457869425338938 0.307639389508665 no 2337 0.323523127053498 3199 5994525
SGTC_137 0438-0332 85.389 µM -0.459290586825123 0.307145475083559 no 2338 0.323012753276363 3322 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1671 st016596 74.5 µM -0.459340190292687 0.307128242066848 no 2339 0.322994945470452 3286 2829167
SGTC_2268 7933382 153.85 µM -0.459459150883009 0.307086915042055 no 2340 0.322952239885698 3295 935025 YOR257W CDC31
SGTC_2892 9047358 58.44 µM -0.460749828748233 0.306638689909856 no 2341 0.322489050422774 3225 6466771
SGTC_169 k015-0017 16.025 µM -0.461249761713675 0.306465151383619 no 2342 0.322309711924241 3422 1840002
SGTC_827 3253-0474 693 µM -0.462098221415815 0.306170730333831 no 2343 0.322005442797094 3319 5402065
SGTC_863 0466-0191 129 µM -0.462176848807918 0.306143452449198 no 2344 0.321977251986632 3316 765160 YPR165W RHO1
SGTC_642 0335-0876 158 µM -0.462375348366909 0.306074592578169 no 2345 0.321906087155739 3250 6812350
SGTC_616 4092-0450 108 µM -0.463175585732465 0.305797058240308 no 2346 0.321619257280735 3261 787165
SGTC_2383 9036125 200 µM -0.463717474152251 0.305609186499008 no 2347 0.3214250880258 3195 79580
SGTC_2444 5485484 36.41 µM -0.463852748688394 0.305562295039112 no 2348 0.32137662411247 3307 6790631
SGTC_2852 9023854 51.95 µM -0.464543215437416 0.305323001875645 no 2349 0.321129302544455 3358 19798528
SGTC_2639 lactacystin 53 µM -0.464845113420898 0.305218400047335 no 2350 0.321021189186446 3366 3870 A proteasome inhibitor.
SGTC_1019 4262-0212 3.4 µM -0.465818107018469 0.304881384809354 no 2351 0.320672851565626 3311 4677213
SGTC_1086 cerivastatin 2.18 µM -0.466493212062972 0.304647646269755 no 2352 0.320431252595647 3290 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_102 gallobenzophenone 83.616 µM -0.469399748616091 0.303642240878696 no 2353 0.319391964014947 3370 70837
SGTC_3192 9110362 49.47 µM -0.469897306021385 0.303470278471756 no 2354 0.319214194557735 3339 16649480
SGTC_2200 6600604 21.907 µM -0.47142268783808 0.302943357719033 no 2355 0.318669458704464 3233 2904777
SGTC_1868 st057644 42.7 µM -0.472545878391144 0.302555630006071 no 2356 0.318268601419269 3203 688665
SGTC_405 ebelactone b 50 µM -0.474600866678056 0.301846820192268 no 2357 0.317535744204066 3265 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_246 cycloheximide 667 µM -0.477152151684866 0.300967866876507 no 2358 0.316626890202924 3197 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2848 9016370 25.97 µM -0.477682270063482 0.300785378587386 no 2359 0.316438182702658 3388 7894410
SGTC_1719 st032227 49.2 µM -0.478733750591274 0.30042356405353 no 2360 0.316064026091133 3230 3125804
SGTC_1336 1486-0901 104 µM -0.478835298940128 0.300388631672335 no 2361 0.316027901306513 3303 5006114
SGTC_1806 st050005 60.3 µM -0.479640627212198 0.300111665749628 no 2362 0.315741476250013 3253 5194765
SGTC_1754 st042065 16.137 µM -0.480095982691509 0.29995511248428 no 2363 0.315579572333355 3330 1126236 YIL048W NEO1
SGTC_2162 5663267 200 µM -0.480358683126395 0.299864811705365 no 2364 0.315486183977195 3380 6456493
SGTC_1963 st076565 50.3 µM -0.481198088064458 0.299576356751953 no 2365 0.315187859796493 3224 4914280
SGTC_3350 9150499 3.57 µM -0.481684136486689 0.299409387513545 no 2366 0.315015173447035 3253 4910996 YPR165W RHO1
SGTC_3156 9099931 49.47 µM -0.485288982431173 0.298172356183323 no 2367 0.313735684854134 3208 18111053
SGTC_878 0828-0289 13.7 µM -0.489465347862641 0.296742121564999 no 2368 0.312256140729533 3275 745350 YLR208W SEC13
SGTC_3112 9123419 49.47 µM -0.493219121297423 0.29545929424871 no 2369 0.310928884257152 3355 17015854
SGTC_231 b-estradiol 524 µM -0.493951249315563 0.295209391889004 no 2370 0.310670304633298 3241 450 A steroid.
SGTC_2736 butenafine 14.65 µM -0.493986241478522 0.295197450206982 no 2371 0.310657948123578 3265 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.495360275134413 0.294728713331547 no 2372 0.310172915303726 3377 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_510 ag-490 170 µM -0.497774677641446 0.29390589827194 no 2373 0.309321432945966 3421 5328779
SGTC_1349 flufenamic acid 69 µM -0.498396602743228 0.293694121827788 no 2374 0.309102265403254 3290 3371 A non-steroidal anti-inflammatory.
SGTC_1788 fluconazole 20 µM -0.498608216140662 0.29362207984851 no 2375 0.309027707939609 3356 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3275 9138069 49.47 µM -0.499852826710746 0.293198528431995 no 2376 0.308589355244451 3360 17617007
SGTC_1810 st050138 53 µM -0.500012475350137 0.293144219165612 no 2377 0.308533146601463 3361 3444541
SGTC_300 r073-0011 5.04 µM -0.500027973770529 0.293138947162141 no 2378 0.308527690200201 3391 2735780
SGTC_1345 1488-0192 31.4 µM -0.501083308030304 0.29278006399783 no 2379 0.308156246878352 3387 658348
SGTC_2302 7771753 200 µM -0.50139772470036 0.292673181077021 no 2380 0.30804562039445 3331 2203047
SGTC_1031 k035-0009 16 µM -0.502233481648655 0.292389161699493 no 2381 0.307751646833564 3404 5180959
SGTC_874 0599-0792 117 µM -0.504418801279045 0.291647120119926 no 2382 0.306983554388836 3436 765305
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.504766518692945 0.291529131079923 no 2383 0.30686141722491 3308 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1866 st057638 64 µM -0.505886696032637 0.291149178907565 no 2384 0.306468096163471 3305 688802
SGTC_3124 9127567 49.47 µM -0.506201745846018 0.291042359059346 no 2385 0.30635751476904 3401 17592030
SGTC_158 k038-0087 26.446 µM -0.507948215398154 0.290450538619735 no 2386 0.305744830046454 3253 X158
SGTC_898 1000-0849 28.3 µM -0.508213185128209 0.29036079843144 no 2387 0.305651922575779 3352 6751807
SGTC_1519 esterone 74 µM -0.509234496627588 0.290015021248828 no 2388 0.30529393283623 3237 698 A steroid.
SGTC_2865 9030313 51.95 µM -0.511401885010818 0.289281866295815 no 2389 0.304534837630101 3237 42562754
SGTC_1103 duloxetine 36.1 µM -0.511887453248897 0.289117734325084 no 2390 0.304364889859881 3412 60835 A selective serotonin reuptake inhibitor.
SGTC_1600 coumarin 106 71.1 µM -0.512363839110166 0.288956748755419 no 2391 0.304198196946133 3430 100336 A hepatotoxic, DNA x-linker.
SGTC_1951 sophoraflavanone G 9.2 µM -0.512553744754389 0.288892585503347 no 2392 0.304131758107913 3288 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1271 0832-2808 169 µM -0.512936464787616 0.288763296601038 no 2393 0.303997882451866 3414 3663794
SGTC_2979 9012552 45.46 µM -0.512947939851656 0.288759420562939 no 2394 0.303993868874511 3419 17100905
SGTC_499 genistein 192 µM -0.515231245017751 0.287988655370593 no 2395 0.303195718867138 3386 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1748 st037455 53.6035 µM -0.516293775366821 0.287630313152853 no 2396 0.302824621522363 3426 580690
SGTC_3264 9137442 49.47 µM -0.517088680945073 0.287362366244175 no 2397 0.30254712736651 3481 17015726
SGTC_2399 5884133 200 µM -0.520726075591327 0.286137781539402 no 2398 0.301278803423183 3313 722445
SGTC_535 2293-4129 48.2 µM -0.523616325455017 0.285166505530121 no 2399 0.3002727121577 3437 396118 YIL048W NEO1
SGTC_2825 7998094 58.44 µM -0.526100256380564 0.284333031578074 no 2400 0.299409275272847 3338 2987815
SGTC_1781 st038725 66.3 µM -0.526712985570494 0.284127611697551 no 2401 0.299196458292264 3306 4270275 YIL048W NEO1
SGTC_1840 st055363 71 µM -0.527440929977629 0.283883657750156 no 2402 0.29894371329295 3347 676033
SGTC_2891 9063876 19.48 µM -0.528494565484128 0.283530733544385 no 2403 0.298578059007352 3358 6472478
SGTC_880 0833-0487 87.2 µM -0.530385431907071 0.282897899445781 no 2404 0.297922362243848 3386 76075
SGTC_2621 lithochol-11-enic acid 100 µM -0.530519046776436 0.282853206968106 no 2405 0.297876053387264 3442 6708711
SGTC_449 xestospongin c 11.1929 µM -0.530632489210997 0.28281526457576 no 2406 0.297836738562532 3395 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_354 2783-3500 4.88 µM -0.534210648734523 0.281619756033285 no 2407 0.296597901248664 3321 6740761
SGTC_2475 5812728 15.03 µM -0.535724140556287 0.28111481365012 no 2408 0.296074608494465 3390 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_715 0868-0130 184 µM -0.537113634041894 0.280651625899595 no 2409 0.295594561809727 3476 2876258
SGTC_864 0469-0573 172 µM -0.537122709464952 0.280648601820697 no 2410 0.295591427579825 3347 689425
SGTC_3294 9122953 26.2835 µM -0.537659277763569 0.280469836540734 no 2411 0.295406148954249 3414 16459826
SGTC_3092 9117248 49.47 µM -0.538124430828202 0.280314908867596 no 2412 0.295245573466669 3422 17141857
SGTC_1779 st039427 55 µM -0.538131076847617 0.280312695590526 no 2413 0.29524327948548 3483 1124498
SGTC_428 3448-4153 16.5 µM -0.538146595948384 0.280307527406579 no 2414 0.29523792284857 3259 3834874
SGTC_2201 6605497 169.863 µM -0.539382082536837 0.279896232776191 no 2415 0.294811620818748 3388 670741
SGTC_2833 9001315 45.46 µM -0.540553503253691 0.279506536233376 no 2416 0.294407686859796 3284 2989378
SGTC_2945 9067681 61.76 µM -0.541686886078866 0.279129744700611 no 2417 0.294017112650958 3467 16456930
SGTC_1560 lithocholic acid 53.1 µM -0.542426520312474 0.278883987569821 no 2418 0.293762357089973 3392 9903 A bile acid which acts as a detergent.
SGTC_651 3253-0966 34.4 µM -0.542619080862677 0.278820023048339 no 2419 0.293696049350673 3362 781462
SGTC_1785 bathophenanthroline 24 µM -0.543172932389028 0.278636085155231 no 2420 0.293505370601855 3323 72812 An iron chelator.
SGTC_1492 4158-0558 28.5 µM -0.543620872572811 0.278487364378894 no 2421 0.293351196719871 3426 3967268
SGTC_3191 9110352 49.47 µM -0.544178866726569 0.278302158654306 no 2422 0.293159196520821 3424 17122424
SGTC_1078 idebenone 36.1 µM -0.545862025244457 0.277743859816842 no 2423 0.292580391819072 3422 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2408 sulbentine 18.36 µM -0.545941398146244 0.277717545564265 no 2424 0.292553110173577 3294 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1150 3909-7983 10.9 µM -0.546087613901288 0.277669074295044 no 2425 0.292502856741184 3355 23965914
SGTC_166 k072-0058 166.424 µM -0.546156586188804 0.277646211064152 no 2426 0.292479152793901 3471 5846229
SGTC_3053 9095903 49.47 µM -0.546287950578158 0.277602668374594 no 2427 0.292434008804636 3457 17174018
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.546645215149351 0.277484264572799 no 2428 0.292311249544471 3354 688667
SGTC_1859 st055998 20 µM -0.547121453726043 0.277326469072 no 2429 0.29214764704375 3492 676301
SGTC_3223 9129970 49.47 µM -0.548288094375907 0.276940103272289 no 2430 0.291747050487873 3408 17248386
SGTC_3279 9140807 49.47 µM -0.548581438300405 0.276842995678846 no 2431 0.291646363473057 3442 45595718
SGTC_896 0964-0007 44.5 µM -0.549832427449364 0.276429059712515 no 2432 0.291217157412935 3441 6756758
SGTC_3147 9097027 49.47 µM -0.550828380876287 0.276099728896721 no 2433 0.290875663396484 3372 25236841
SGTC_1853 st056710 91.2 µM -0.551095119502876 0.276011559444316 no 2434 0.290784235440856 3488 269167
SGTC_3119 9125183 49.47 µM -0.551984091875784 0.275717812827191 no 2435 0.290479626243766 3312 22695334
SGTC_2951 9072950 58.06 µM -0.553572841054728 0.275193219236894 no 2436 0.28993560859823 3475 16488155
SGTC_3025 9087895 49.47 µM -0.554466526383524 0.274898346864781 no 2437 0.289629804018149 3469 17173641
SGTC_3281 9140613 49.47 µM -0.554664062868871 0.274833190521419 no 2438 0.289562230684276 3391 16013766
SGTC_1632 st005650 90 µM -0.554747517299605 0.274805665815447 no 2439 0.289533684794698 3419 2759605
SGTC_1711 st032263 62.8 µM -0.555375445361978 0.274598607934034 no 2440 0.289318942121826 3399 3958979
SGTC_2857 9024691 58.44 µM -0.55544475361017 0.274575758410178 no 2441 0.289295244251179 3427 16478292
SGTC_1130 3454-2858 15.9 µM -0.555690390202008 0.274494784560936 no 2442 0.289211263554052 3367 715628 YIL048W NEO1
SGTC_3079 9117512 49.47 µM -0.557065985965961 0.274041538716609 no 2443 0.288741173036167 3466 7185044
SGTC_758 0868-0029 16 µM -0.557470957255156 0.273908174989913 no 2444 0.28860284837198 3475 762687
SGTC_2677 mitomycin C 100 µM -0.56128237070661 0.272654587891461 no 2445 0.287302528837815 3452 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2372 9071633 200 µM -0.562876138572253 0.27213123769486 no 2446 0.286759614761379 3483 21321366
SGTC_2902 5787006 60.46 µM -0.563389737842892 0.271962692062784 no 2447 0.286584761793272 3375 591003
SGTC_2024 5144227 134 µM -0.565361835782487 0.271316000113245 no 2448 0.285913838682743 3450 3475211
SGTC_1977 st070720 65.3 µM -0.565548845152402 0.271254715655746 no 2449 0.285850255417102 3472 682188
SGTC_269 exalamide 29 µM -0.565724268973968 0.271197234147558 no 2450 0.285790617355239 3379 3316 A derivative of salicylamide.
SGTC_1982 st072467 71.9 µM -0.56601272840986 0.271102727217116 no 2451 0.285692563942505 3328 3163533
SGTC_1358 1509-0022 2.48 µM -0.566802811048974 0.27084395940535 no 2452 0.285424080266583 3464 3258434
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.567245625446693 0.270698982791968 no 2453 0.285273656872574 3420 15053
SGTC_2595 hexamethylquercetagetin 100 µM -0.5681951513911 0.270388240445475 no 2454 0.284951231703386 3383 386331
SGTC_490 phenamil 164 µM -0.568602217546656 0.270255078388546 no 2455 0.284813059791736 3409 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_290 2043-6722 48.1 µM -0.568660019441192 0.270236172526064 no 2456 0.284793442481637 3472 773758 YLR208W SEC13
SGTC_2141 5621638 7.665 µM -0.568955915081892 0.270139401243061 no 2457 0.28469302894357 3480 2856238
SGTC_2258 7960471 200 µM -0.569146887381526 0.270076953852283 no 2458 0.28462823059574 3423 2974708
SGTC_3256 9138902 49.47 µM -0.569148988508563 0.270076266829975 no 2459 0.284627517706586 3443 17228773
SGTC_1412 3909-8563 178 µM -0.570474503315311 0.269643026995084 no 2460 0.284177955200654 3527 23767530
SGTC_2136 5328288 199.296 µM -0.57064409697577 0.269587621038675 no 2461 0.284120460208457 3393 262395
SGTC_274 sirtinol 40.1 µM -0.570847665213924 0.269521123180089 no 2462 0.284051454632898 3447 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2711 st079103 59.1 µM -0.575128882590804 0.26812452244826 no 2463 0.2826020678251 3416 54693780
SGTC_1091 telmisartan 47.6 µM -0.576239304802167 0.267762880972244 no 2464 0.282226720822956 3520 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1423 4048-0112 5.59 µM -0.576602546469893 0.267644634067786 no 2465 0.282103989293139 3481 X1423
SGTC_807 1315-0151 48 µM -0.57727684464719 0.267425198016919 no 2466 0.281876226624308 3545 4011080
SGTC_3159 9100096 49.47 µM -0.577316376421219 0.267412336055368 no 2467 0.281862876435431 3445 25236875
SGTC_2650 prasterone 100 µM -0.579196737858989 0.266800906866738 no 2468 0.281228215854813 3453 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2640 pentamidine 10.38 µM -0.579324620563843 0.266759349459059 no 2469 0.281185077889523 3481 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_632 0781-2353 4.65 µM -0.579773201184979 0.266613602310803 no 2470 0.281033785939528 3500 6811515 YHR007C ERG11
SGTC_1851 st056236 18.9 µM -0.582070781110257 0.265867733451968 no 2471 0.280259502674032 3536 5393171
SGTC_2147 5545932 89.7195 µM -0.582197367228523 0.265826670253537 no 2472 0.280216873268769 3469 797404
SGTC_1433 4060-0023 7.6 µM -0.582683396181957 0.265669037469242 no 2473 0.280053226335981 3493 3840627
SGTC_337 1315-0038 354 µM -0.583495059736642 0.265405897987936 no 2474 0.279780040894454 3441 1626437
SGTC_1676 st018489 23.4 µM -0.584081337058502 0.265215910517588 no 2475 0.279582795216063 3429 3696235
SGTC_2969 9091408 28.7 µM -0.585545284954221 0.264741809146043 no 2476 0.279090563187937 3369 4286311
SGTC_2606 farnesol 9.78 µM -0.586761084416053 0.264348398782974 no 2477 0.278682088160096 3530 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2868 9035608 32.47 µM -0.586877391748801 0.264310779470809 no 2478 0.278643027369525 3498 6462614
SGTC_1190 1486-1332 13 µM -0.587670477431691 0.264054330598817 no 2479 0.278376747638305 3469 4150046
SGTC_2468 5987765 72.9 µM -0.587771253714965 0.264021753081926 no 2480 0.27834292072959 3434 26772094
SGTC_648 0375-0473 33.3 µM -0.592093823662547 0.262626345084199 no 2481 0.276893881292459 3498 1713139
SGTC_1370 2001-0092 44.6 µM -0.593291595971307 0.262240350168807 no 2482 0.276493011043996 3612 790957
SGTC_2676 harmalol 100 µM -0.59396515107732 0.262023417584364 no 2483 0.27626771079683 3531 5459187 A monoamine oxidase inhibitor
SGTC_39 0986-0283 58.349 µM -0.594013067004925 0.262007988757953 no 2484 0.276251686631709 3571 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_817 1391-0715 46 µM -0.594106323998053 0.2619779615406 no 2485 0.276220500700988 3442 1353946
SGTC_190 3970-0790 3.722 µM -0.594170459367816 0.261957312030758 no 2486 0.27619905429122 3496 2832352
SGTC_3210 9128157 49.47 µM -0.595867972163539 0.261411071455318 no 2487 0.275631715379501 3407 17590849
SGTC_2860 9025725 38.96 µM -0.596852397805077 0.261094562515975 no 2488 0.275302965547745 3387 40546248
SGTC_734 2023-0417 80 µM -0.597130435680223 0.261005204481299 no 2489 0.275210149510979 3487 3935732
SGTC_2353 9059630 146.67 µM -0.597458239445508 0.260899872488614 no 2490 0.275100740160834 3501 4779114
SGTC_3326 9140064 16.379 µM -0.597573438791213 0.260862861093827 no 2491 0.275062295764509 3476 1868434
SGTC_2607 solasodine 47.35 µM -0.598100379577773 0.260693599313424 no 2492 0.274886478505046 3478 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2448 5185112 27.17 µM -0.600014324718488 0.26007928544958 no 2493 0.274248344421957 3509 5718189
SGTC_626 0214-0009 33 µM -0.600534404070601 0.2599124860163 no 2494 0.274075069720742 3540 3437874
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.602254364309103 0.259361255000733 no 2495 0.273502416555128 3453 4174840
SGTC_1691 st019933 84.6 µM -0.602313681276387 0.25934225525288 no 2496 0.273482677802618 3505 6176082
SGTC_3306 9127676 59.7925 µM -0.602504470743623 0.259281148580356 no 2497 0.273419194071341 3481 41905287
SGTC_773 4358-1457 44.6 µM -0.603874073204993 0.258842706359281 no 2498 0.272963683661228 3549 1186886
SGTC_2732 terfenadine 20 µM -0.604026675001108 0.258793878670005 no 2499 0.272912953768965 3505 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_968 1309-0633 340 µM -0.604145306576374 0.258755923657214 no 2500 0.272873519933784 3519 3761976
SGTC_691 1548-0686 185 µM -0.607863720067268 0.257567715657854 no 2501 0.271638931745676 3483 46495133
SGTC_2529 gangaleoidin 93.61 µM -0.609868484841108 0.256928276768511 no 2502 0.270974465281493 3540 4565183
SGTC_2112 5488546 200 µM -0.610578896247056 0.256701882628261 no 2503 0.270739198708465 3487 600757
SGTC_2863 9028737 58.44 µM -0.610876795892294 0.256606978789295 no 2504 0.270640573796915 3476 6460917
SGTC_554 4483-2211 187 µM -0.611334139304908 0.256461315474076 no 2505 0.270489197151185 3486 747107
SGTC_2155 5570423 76 µM -0.613280148025657 0.25584199606609 no 2506 0.269845558741238 3461 797402
SGTC_3272 9137413 49.47 µM -0.614499691405681 0.25545427330685 no 2507 0.26944258846604 3502 17614870
SGTC_244 nsc-207895 1.295 µM -0.614730475349156 0.255380935992409 no 2508 0.269366365136462 3426 42640
SGTC_2075 5212009 200 µM -0.615121423062656 0.255256727785286 no 2509 0.269237267585536 3499 780898
SGTC_3109 9122853 49.47 µM -0.616258080997797 0.254895779068466 no 2510 0.268862100271256 3538 1234709
SGTC_1970 st070122 35.8 µM -0.616465145823211 0.254830053863419 no 2511 0.268793784369824 3600 102928
SGTC_2238 6671620 73.2395 µM -0.617547749973234 0.254486565004582 no 2512 0.268436748009615 3529 729941
SGTC_111 0083-0039 52.457 µM -0.618164026772837 0.254291140989174 no 2513 0.268233610178384 3468 759313
SGTC_2558 carylophyllene oxide 100 µM -0.61821303821042 0.254275602630102 no 2514 0.268217458295553 3615 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2366 9070441 60.58 µM -0.618285604654267 0.254252597415147 no 2515 0.268193544680507 3517 6837235
SGTC_373 0844-0104 25.9 µM -0.618374082083641 0.254224549532009 no 2516 0.268164389195699 3561 5375804
SGTC_1887 st057648 70.8 µM -0.618615828224187 0.254147922808624 no 2517 0.268084736041998 3550 688672
SGTC_2933 9026794 32.47 µM -0.618791176550829 0.254092349904303 no 2518 0.268026967816789 3498 17586027
SGTC_3219 9131112 49.47 µM -0.620092488653186 0.253680126115783 no 2519 0.267598448560753 3502 17612988 YMR079W SEC14
SGTC_2659 sanguinarine 24.21 µM -0.620941279644364 0.253411439300763 no 2520 0.267319129750027 3495 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1210 3013-0140 750 nM -0.62397262656996 0.252453081462245 no 2521 0.26632278111385 3582 905973
SGTC_3244 9134489 49.47 µM -0.624634236906596 0.252244168115654 no 2522 0.266105571937511 3524 16584271
SGTC_3208 9114115 49.47 µM -0.626476155253948 0.251663035403852 no 2523 0.265501336078564 3499 650895
SGTC_985 1493-0307 8.71 µM -0.626668715199559 0.251602322813041 no 2524 0.265438207569917 3561 3278274
SGTC_1026 k007-1105 30.6 µM -0.629534065191401 0.250699816105439 no 2525 0.264499737124372 3563 7066794
SGTC_1159 4092-0538 61.2 µM -0.630044299010518 0.25053928645881 no 2526 0.26433280065071 3598 717301
SGTC_1679 SEC14.276 6.7 µM -0.630590529730801 0.250367491855506 no 2527 0.264154146308656 3557 1005053 YMR079W SEC14
SGTC_990 3985-0011 41.3 µM -0.630919902212741 0.250263931356688 no 2528 0.264046448992186 3516 5399565 YGL099W LSG1
SGTC_2157 5649910 96.377 µM -0.632464168338064 0.249778689986895 no 2529 0.263541807596207 3545 2858091
SGTC_924 2046-0044 21.3 µM -0.632948887362201 0.249626483999399 no 2530 0.263383510744726 3586 3623589
SGTC_684 1140-0066 328 µM -0.633109974411935 0.249575912174569 no 2531 0.26333091457825 3576 6813534
SGTC_1001 4048-4355 44.4 µM -0.633324142495687 0.249508684468039 no 2532 0.263260995350333 3564 21824233
SGTC_1734 st037168 69.4 µM -0.63359553049949 0.249423509160415 no 2533 0.263172409217772 3516 708907
SGTC_2706 st078239 82.5 µM -0.633627345254164 0.249413525090354 no 2534 0.26316202528272 3592 15434492
SGTC_439 amiodarone 34.4 µM -0.633811964357223 0.249355592326754 no 2535 0.263101772065684 3502 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_846 0335-0850 148 µM -0.634117251339605 0.249259810143693 no 2536 0.263002152542376 3558 6819598
SGTC_2166 5933061 31.504 µM -0.635081621604508 0.248957372602628 no 2537 0.262687591379321 3788 2877375
SGTC_1778 st046819 58.9 µM -0.635127500509046 0.24894298932147 no 2538 0.262672631259525 3571 671715
SGTC_3030 9087619 49.47 µM -0.635630498913579 0.248785325647635 no 2539 0.262508642936853 3533 25236973
SGTC_2834 9001755 58.44 µM -0.637633326229606 0.24815807176771 no 2540 0.261856198232952 3478 2989575
SGTC_640 3381-0960 37.1 µM -0.637931740935853 0.248064685249001 no 2541 0.26175905734913 3608 1745025
SGTC_1119 parthenolide 318.541 nM -0.638322025200997 0.247942577179897 no 2542 0.261632038707245 3630 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1153 4055-0057 267 µM -0.638415000446818 0.247913492786689 no 2543 0.261601784429992 3554 882706
SGTC_1045 1348-1485 165 µM -0.638612813552948 0.247851619211625 no 2544 0.261537421738691 3610 6810614
SGTC_787 4152-0075 138 µM -0.639054819309457 0.24771339488747 no 2545 0.261393635168991 3555 9566539
SGTC_661 1304-0007 33.6 µM -0.639953350435732 0.247432532601033 no 2546 0.261101463932204 3566 3117130
SGTC_2784 7567673 72.73 µM -0.640193200074576 0.247357589341551 no 2547 0.261023501522105 3601 3471247
SGTC_2733 amorolfine 100 µM -0.640474794510026 0.247269618017659 no 2548 0.260931985367074 3584 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2385 9074692 200 µM -0.641097320368957 0.247075197618662 no 2549 0.260729727543172 3540 17046906
SGTC_2661 dactinomycin 12.96 µM -0.641382815087654 0.246986062420649 no 2550 0.260636997678721 3600 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_687 k029-0044 34.9 µM -0.642224850176151 0.246723268257847 no 2551 0.260363600103354 3595 5829338
SGTC_430 0958-0115 16.4 µM -0.642941975178309 0.246499575902585 no 2552 0.260130875708433 3532 6833180
SGTC_347 4534-1311 26.2 µM -0.643533672754622 0.246315089896118 no 2553 0.259938936315059 3598 2862016
SGTC_3328 9140624 29.0385 µM -0.645378005801679 0.245740518600273 no 2554 0.25934112646999 3602 4904392
SGTC_972 1319-0219 195 µM -0.646237060840187 0.245473140140522 no 2555 0.259062920773221 3556 23903702
SGTC_1331 1472-0049 76.2 µM -0.648195253615272 0.244864242865698 no 2556 0.258429335707183 3564 24051409
SGTC_1104 tacrolimus 29.8 µM -0.650131347340455 0.244263017331549 no 2557 0.257803691056339 3630 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_862 0452-0056 10.2 µM -0.65114310829027 0.243949146671001 no 2558 0.257477055629128 3552 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_460 trequinsin 123 µM -0.651298304090057 0.243901020752111 no 2559 0.257426971468335 3625 5537 A vasodilator.
SGTC_2182 6325192 200 µM -0.651390609705107 0.243872399388345 no 2560 0.257397185374336 3557 736248
SGTC_1565 sinapyl alcohol 95.1 µM -0.651874802542252 0.243722294561047 no 2561 0.257240970552886 3576 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3187 9109394 49.47 µM -0.654079854407813 0.243039336738843 no 2562 0.256530179887084 3558 17098090
SGTC_1054 3429-0080 167 µM -0.654613876073598 0.242874093161323 no 2563 0.256358193907276 3618 1162877
SGTC_2812 7970281 58.44 µM -0.654617306344694 0.242873031921025 no 2564 0.256357089355108 3631 2233435
SGTC_2323 6148992 148.28 µM -0.654684870819607 0.24285212966954 no 2565 0.256335334003707 3555 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_451 chloral hydrate 100 µM -0.655924700092786 0.242468739691714 no 2566 0.255936287398328 3654 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2419 paclitaxel 166.5 µM -0.656260952031122 0.242364817709102 no 2567 0.255828118566803 3562 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_152 4469-0003 551.229 µM -0.65632412916358 0.2423452948859 no 2568 0.255807797788491 3599 697280
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.65652233627593 0.242284051001607 no 2569 0.255744050398518 3677 688664
SGTC_234 nsc-17383 10.7 µM -0.657942352892409 0.241845526422121 no 2570 0.255287587193709 3639 408974
SGTC_3003 9075612 71.4286 µM -0.658047348045286 0.241813119292771 no 2571 0.25525385350372 3602 6501993
SGTC_1893 st059353 36.1 µM -0.658310054495677 0.241732044332763 no 2572 0.255169459266966 3577 3112488
SGTC_2658 polymyxin b sulfate 77.05 µM -0.658367749379241 0.241714240844359 no 2573 0.255150926786226 3589 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_747 3448-8087 38.7 µM -0.660573743388082 0.241034049312828 no 2574 0.254442856046544 3620 5168703
SGTC_1414 3917-0015 5.4 µM -0.661517142191383 0.240743481767652 no 2575 0.254140362480021 3598 6618702
SGTC_2506 ethyl hematommate 54.16 µM -0.661950753777573 0.240609993041317 no 2576 0.254001391557032 3582 3940691 An allergen.
SGTC_1136 pergolide 1.05886 µM -0.662053916584904 0.240578239972922 no 2577 0.253968334128263 3602 47811 A dopamine receptor agonist.
SGTC_1905 st060207 84.5 µM -0.662639302938251 0.240398103781111 no 2578 0.253780796031903 3555 1948547
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.662918065591751 0.240312348242317 no 2579 0.253691515416792 3622 5377381
SGTC_2893 9048488 25.97 µM -0.664020147831633 0.239973478792509 no 2580 0.253338707972167 3575 6467338
SGTC_57 miconazole 162.5 nM -0.664408664558893 0.239854079397473 no 2581 0.253214394385315 3563 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3299 9121982 43.1275 µM -0.665486659656031 0.239522958504284 no 2582 0.252869636652559 3622 17594604 YPL160W CDC60
SGTC_2567 aureobasidin a 60 nM -0.665757046459957 0.23943994467763 no 2583 0.252783201990172 3685 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2371 9071574 200 µM -0.666051112626248 0.239349678680647 no 2584 0.252689215397528 3594 45596039
SGTC_3010 9080089 71.4286 µM -0.666409876217359 0.239239578460063 no 2585 0.2525745757649 3627 17027233
SGTC_80 0159-0065 512.242 µM -0.666798515874642 0.239120340866139 no 2586 0.252450420431591 3570 1548079
SGTC_1391 3442-0225 151 µM -0.667205616649128 0.238995474101238 no 2587 0.252320401984288 3588 5227075
SGTC_1886 st057356 49.9 µM -0.667370223038654 0.238944995822983 no 2588 0.252267840585437 3583 24207747
SGTC_1381 2324-0066 62.1 µM -0.668024253154675 0.238744488230028 no 2589 0.252059055576867 3618 10885928
SGTC_1915 st067105 30.6 µM -0.668347471110229 0.238645432517018 no 2590 0.251955908884593 3623 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1152 3909-8331 15.9 µM -0.668370304791629 0.238638435592476 no 2591 0.251948622945307 3611 16001939
SGTC_75 0159-0059 199.013 µM -0.668604868603131 0.238566564708998 no 2592 0.251873783034705 3710 5377270
SGTC_285 1486-1325 46 µM -0.669495788231744 0.238293692905844 no 2593 0.251589633253605 3630 22310230
SGTC_1386 3228-0095 33.8 µM -0.671586797492815 0.237653928400569 no 2594 0.250923392776404 3619 870181
SGTC_2793 7325131 81.82 µM -0.671804807016098 0.237587280571779 no 2595 0.250853984050927 3607 4176441
SGTC_1330 1469-0054 61.8 µM -0.672411308503708 0.23740192059035 no 2596 0.250660942777326 3649 7102664
SGTC_2960 9079389 5.97 µM -0.673019775283403 0.237216039785787 no 2597 0.250467355070433 3613 16457355
SGTC_810 3825-7150 143 µM -0.674490759476595 0.236766998565758 no 2598 0.249999679274407 3666 22330411 YGL099W LSG1
SGTC_463 ikarugamyin 104 µM -0.674948770151214 0.236627279050396 no 2599 0.24985415679499 3675 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3072 9116419 49.47 µM -0.675166671866195 0.236560822461342 no 2600 0.249784939267721 3603 17170162
SGTC_2128 5255449 168.493 µM -0.675751227808485 0.236382592852196 no 2601 0.249599302565734 3647 736008
SGTC_1558 st069300 45.6 µM -0.675979585723899 0.236312987193801 no 2602 0.249526803139767 3593 24208000
SGTC_2665 lovastatin 100 µM -0.677915610219025 0.235723322215273 no 2603 0.248912600886152 3635 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2537 larixol 68.93 µM -0.678107477042225 0.235664928569371 no 2604 0.248851775140869 3652 6708759
SGTC_858 0438-0351 2.77 µM -0.679648030576824 0.235196358627802 no 2605 0.248363674810348 3655 2799119
SGTC_1318 1280-3875 124 µM -0.680778948855206 0.234852709786835 no 2606 0.248005686096694 3639 373245
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.683299758570283 0.234087718352668 no 2607 0.247208723354939 3481 4000243
SGTC_531 3788-1495 174 µM -0.683859354811409 0.233918084758603 no 2608 0.247031990998021 3627 2896655
SGTC_415 dibenzyl ketone 100 µM -0.685209899784292 0.233508967046516 no 2609 0.246605738848259 3652 7593
SGTC_1147 3809-1045 12.3 µM -0.685346908667734 0.233467485421213 no 2610 0.24656251882077 3611 325925
SGTC_3047 9092122 49.47 µM -0.685418413612985 0.233445837781676 no 2611 0.2465399638972 3612 17173831
SGTC_2130 NSC 7 2.4545 µM -0.68620808805354 0.233206843236968 no 2612 0.246290949103915 3662 21448
SGTC_1655 st012546 55.1 µM -0.686858228748284 0.233010180483742 no 2613 0.246086035927117 3621 720985 YLR208W SEC13
SGTC_2689 tacrolimus 100 µM -0.686936464600871 0.232986520926845 no 2614 0.246061383496527 3654 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1643 st009866 20.2 µM -0.6876306689072 0.232776642814519 no 2615 0.24584269498133 3653 3156273 YOR207C RET1
SGTC_1828 st055811 49 µM -0.687833920336489 0.232715213896163 no 2616 0.245778686385004 3620 5877589
SGTC_3263 9137018 49.47 µM -0.688186484004018 0.23260867953615 no 2617 0.245667677119819 3616 43844957
SGTC_3337 9144342 33.5465 µM -0.690405164177474 0.231938882241167 no 2618 0.244969715040127 3668 17682949
SGTC_821 1114-0266 29.2 µM -0.690794446532654 0.231821472657631 no 2619 0.244847363014345 3681 3123235
SGTC_2308 7584454 197.62 µM -0.69100466231973 0.231758084251562 no 2620 0.244781305556988 3701 893577
SGTC_1325 1431-0015 227 µM -0.692512400358912 0.231303724493485 no 2621 0.244307800636662 3621 1103340
SGTC_645 0845-0943 5.41 µM -0.692650575943342 0.231262109883483 no 2622 0.244264431322899 3656 1885106
SGTC_2804 7954240 19.48 µM -0.693187780914594 0.23110035850629 no 2623 0.244095857683189 3660 828705
SGTC_662 k832-1615 104 µM -0.69428496799067 0.230770193845036 no 2624 0.243751758017192 3666 5878478
SGTC_1008 4106-0037 6 µM -0.69593343783139 0.230274633267938 no 2625 0.243235257766642 3643 2905394
SGTC_3266 9136860 49.47 µM -0.696024972264885 0.230247133773008 no 2626 0.243206595452508 3610 4871271 YPR165W RHO1
SGTC_2340 7987427 183.45 µM -0.69663444791183 0.230064077139628 no 2627 0.243015795994462 3638 2239331
SGTC_1213 1315-0166 115 µM -0.698668878946342 0.229453623684982 no 2628 0.242379493592324 3653 768401
SGTC_213 1246-0773 967 nM -0.700030027519963 0.229045703420719 no 2629 0.241954276110397 3642 6251622
SGTC_261 5-fluorouridine 15.376 µM -0.701930961443162 0.228476697254712 no 2630 0.24136110960387 3706 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1486 3970-0793 4.53 µM -0.702206908334879 0.228394164186189 no 2631 0.241275068985068 3717 2844330
SGTC_3284 9108171 64.8615 µM -0.702499472275086 0.228306679417447 no 2632 0.241183865354531 3637 8687505
SGTC_154 3389-1638 511.116 µM -0.702586253718617 0.228280732970592 no 2633 0.241156815786279 3605 5238686
SGTC_394 menadione 8.33 µM -0.703736959689425 0.227936844598277 no 2634 0.240798299446568 3640 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_67 0335-0847 266 µM -0.70446239478623 0.227720198252345 no 2635 0.240572430514064 3770 4552207 YOR254C SEC63
SGTC_1958 st076513 41.9 µM -0.70511897678615 0.227524214390473 no 2636 0.240368098928647 3661 732122 YGL099W LSG1
SGTC_103 0844-0104 51.839 µM -0.705628252567279 0.227372265554275 no 2637 0.240209674898598 3717 5375804
SGTC_845 0330-0138 4.51 µM -0.706633139814088 0.227072612561545 no 2638 0.239897244478838 3653 9039800
SGTC_937 3122-0005 46.7 µM -0.706672012549788 0.227061025356155 no 2639 0.239885162975198 3675 759535
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.707965074088977 0.226675778927819 no 2640 0.239483473378488 3721 5379071
SGTC_2800 7887935 81.82 µM -0.70798421633472 0.226670078582632 no 2641 0.23947752959947 3669 2961002
SGTC_552 k242-0005 476 µM -0.708266401973405 0.226586056265012 no 2642 0.239389918658595 3717 4088318
SGTC_1795 st049545 62.3 µM -0.712459854659397 0.225339506606031 no 2643 0.238090031263623 3646 5291882
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.712903873834868 0.22520774478847 no 2644 0.237952620942758 3721 5282362
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.713796315497381 0.224943046529805 no 2645 0.237676569173168 3644 17037758
SGTC_1925 st057770 10.1 µM -0.714212162568692 0.224819766513506 no 2646 0.237547998593429 3668 5989122
SGTC_2035 5154463 94.595 µM -0.714271756400163 0.224802102752511 no 2647 0.237529576646011 3694 2769623
SGTC_2586 curcumin 80 µM -0.714471988423915 0.224742759242937 no 2648 0.237467685650993 3714 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3020 9089140 49.47 µM -0.714978529623348 0.224592673414438 no 2649 0.237311155128099 3717 17217859
SGTC_1191 1487-1166 10.6 µM -0.716399429879068 0.224171970794303 no 2650 0.236872373437917 3767 3955771
SGTC_3190 9110366 49.47 µM -0.718032163210464 0.223689101319688 no 2651 0.236368727788992 3639 17123768
SGTC_1155 4088-0394 48.2 µM -0.720011905821708 0.223104400327245 no 2652 0.235758832572741 3680 2326248
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.720635047950892 0.222920540556028 no 2653 0.235567042168181 3692 77254
SGTC_1870 st057514 26.5 µM -0.722661792058121 0.222323141481709 no 2654 0.234943847424517 3711 5393161
SGTC_3169 9102970 49.47 µM -0.723396120772188 0.222106917821587 no 2655 0.234718276915675 3772 17027839
SGTC_683 panaxydol 45 µM -0.724943747482649 0.221651611221393 no 2656 0.234243270526641 3691 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1937 st074714 47.2 µM -0.725759111083245 0.221411948656507 no 2657 0.233993228688821 3674 17250970
SGTC_861 0443-0273 110 µM -0.725946548388976 0.221356875531752 no 2658 0.233935769512366 3742 6149169
SGTC_1450 4112-4260 37.6 µM -0.730298239196125 0.220080458869941 no 2659 0.232603952150799 3707 1633175
SGTC_1811 st050069 61.5 µM -0.730906344689518 0.219902429172383 no 2660 0.232418180175775 3700 3877702
SGTC_1774 st048371 48.465 µM -0.731219481900858 0.219810786990709 no 2661 0.232322551145047 3715 4242727
SGTC_113 0099-0221 2.5 µM -0.731492102348853 0.21973102022708 no 2662 0.232239313363868 3726 89219
SGTC_3027 9089541 49.47 µM -0.734180781352631 0.218945222949096 no 2663 0.23141928250082 3706 9943819
SGTC_1341 1486-1360 280 µM -0.735193501125171 0.218649663591372 no 2664 0.23111082820456 3714 3976547
SGTC_2242 6630449 61.2675 µM -0.735209544745094 0.218644983155737 no 2665 0.231105943483976 3794 691249 YDR170C SEC7
SGTC_1392 3455-1037 33.9 µM -0.73726645571638 0.21804539447646 no 2666 0.230480163530406 3727 981132
SGTC_1761 st044296 37 µM -0.737709893884803 0.217916256748098 no 2667 0.230345379269367 3740 1826700
SGTC_3198 9112019 49.47 µM -0.738452898118661 0.217699978505146 no 2668 0.230119639894381 3779 45595555
SGTC_1366 1683-0113 21.9 µM -0.738667450736464 0.217637548261299 no 2669 0.230054477605316 3747 708623
SGTC_2080 5212524 12.4 µM -0.739233412573623 0.217472914994064 no 2670 0.229882637531491 3694 260183
SGTC_36 0335-0881 14.2 µM -0.740075658175231 0.217228046385593 no 2671 0.229627043927767 3685 23828853
SGTC_729 4092-0585 94.1 µM -0.740230749522898 0.217182973578559 no 2672 0.229579996209597 3732 2169061
SGTC_955 1216-0110 33 µM -0.740503322784984 0.217103771149217 no 2673 0.229497322866216 3696 3619719
SGTC_1305 1181-0477 144 µM -0.741063143779228 0.216941154632077 no 2674 0.229327577640435 3753 6252086
SGTC_759 3486-0358 89.3 µM -0.742271041777257 0.21659052497328 no 2675 0.228961566658806 3745 875103
SGTC_184 1494-0393 24.714 µM -0.743825704133752 0.216139719136237 no 2676 0.228490963755162 3733 3090647
SGTC_1985 st071382 65.5 µM -0.744369884373324 0.215982051536197 no 2677 0.228326366565838 3772 6123237
SGTC_1842 st055362 61.2 µM -0.744405724968662 0.215971669631018 no 2678 0.228315528266849 3735 676032
SGTC_1143 3454-2408 5.08 µM -0.744860963168901 0.215839826451682 no 2679 0.22817788809171 3693 X1143
SGTC_418 lividomycin a 100 µM -0.745811394983696 0.215564718860094 no 2680 0.227890677744804 3742 72394 An antibiotic.
SGTC_2446 5162541 200 µM -0.745906485506102 0.215537205592616 no 2681 0.22786195360169 3723 1549321
SGTC_1490 4089-0339 670 nM -0.745928517005526 0.215530831341138 no 2682 0.227855298802822 3696 742542
SGTC_2594 a-mangostin 100 µM -0.746945350251216 0.215236755609067 no 2683 0.227548274835035 3785 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_95 0471-0001 561.058 µM -0.748552336271311 0.21477247845165 no 2684 0.227063534711592 3682 4015405
SGTC_329 k048-0121 21.3 µM -0.749236772780628 0.21457491352081 no 2685 0.226857254433581 3741 6832902
SGTC_2490 carminic acid 95.39 µM -0.749599209692365 0.214470337668021 no 2686 0.226748063479241 3682 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1713 st033146 12.748 µM -0.74966768126477 0.214450584529059 no 2687 0.226727438457772 3719 674619
SGTC_606 k015-0008 38.6 µM -0.750327219654919 0.214260370642491 no 2688 0.226528826382354 3782 1970475
SGTC_2060 5238662 140 µM -0.751413168702097 0.213947391909212 no 2689 0.226202019964059 3742 790130
SGTC_2437 5741531 144.16 µM -0.751664883831947 0.213874883718372 no 2690 0.226126306650121 3785 2262990
SGTC_3257 9139206 32.98 µM -0.752218624746091 0.21371542539282 no 2691 0.225959797514971 3751 4910041
SGTC_2377 9073351 62.6 µM -0.752587070226943 0.213609364153489 no 2692 0.225849044880772 3742 7337946 YHR072W ERG7
SGTC_2493 resveratrol 26.09 µM -0.753370237914307 0.213384022290468 no 2693 0.22561373109969 3668 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3070 9117005 49.47 µM -0.756331903932531 0.212533112122743 no 2694 0.224725112187945 3786 8779016
SGTC_2227 7312221 64.1025 µM -0.757439870118476 0.212215294772733 no 2695 0.224393188638149 3788 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1156 4092-0367 4.88 µM -0.757539880077377 0.212186620840848 no 2696 0.224363241439642 3795 1357585
SGTC_934 2950-0684 338 µM -0.758819552206522 0.211819925011708 no 2697 0.223980253931895 3816 1121253
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.759385935167259 0.211657743860927 no 2698 0.223810862291637 3780 5106787 A p450 inhibitor.
SGTC_2065 5221596 34.26 µM -0.759867904318453 0.211519791473803 no 2699 0.223666774173427 3755 788581
SGTC_9 0092-0002 10.449 µM -0.761442483596732 0.211069472113752 no 2700 0.223196410272747 3752 759368
SGTC_1077 5-fluorocytosine 377 nM -0.76224928994882 0.210838948683632 no 2701 0.222955616571121 3806 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2047 4141938 200 µM -0.762567330434179 0.210748117673318 no 2702 0.222860737140287 3773 3807862
SGTC_1293 1000-1278 195 µM -0.762900441165857 0.210653007279501 no 2703 0.222761386547379 3821 678847
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.762948025874356 0.210639422861249 no 2704 0.222747196423327 3770 641818 YHR062C RPP1
SGTC_2179 6298986 200 µM -0.763088386698299 0.21059935583718 no 2705 0.222705342752969 3710 738374
SGTC_2597 laccaic acid a 100 µM -0.763503177817055 0.210480976816268 no 2706 0.222581683935241 3787 5491415 A textile dye.
SGTC_3087 9117406 49.47 µM -0.763676204840846 0.210431607436253 no 2707 0.222530112154031 3743 42546093
SGTC_6 0844-0013 19.835 µM -0.765787738907563 0.209829676396564 no 2708 0.221901305449551 3878 1584900
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.766890101803233 0.209515830433375 no 2709 0.221573429603894 3841 5282309
SGTC_2858 9025781 8.96 µM -0.767074713580225 0.209463297925466 no 2710 0.221518547595615 3766 4894980 YPL153C RAD53
SGTC_2620 irigenin 100 µM -0.767534989398585 0.209332357133599 no 2711 0.221381749099677 3801 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2757 clomiphene 4.22 µM -0.770077191612799 0.208610011307791 no 2712 0.220627052395573 3836 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_669 0108-0021 26.2 µM -0.770552901136809 0.208475005757964 no 2713 0.220485993676375 3797 17201
SGTC_3319 9138450 16.7555 µM -0.771644910317119 0.20816529037252 no 2714 0.2201623836241 3744 2029690
SGTC_167 3672-0051 66.205 µM -0.772899740697804 0.207809731162403 no 2715 0.219790859107491 3733 3237971
SGTC_2009 4012297 12.05 µM -0.773366711608657 0.207677505462074 no 2716 0.219652692406162 3804 45595307
SGTC_1421 4029-0249 71.4 µM -0.773897989155711 0.20752713139998 no 2717 0.219495559414494 3860 2894095
SGTC_466 geldanamycin 89.2 µM -0.778195726356412 0.206313057271078 no 2718 0.21822681793291 3679 5288382 HSP90 inhibitor.
SGTC_2266 7929956 200 µM -0.779647621673683 0.205903862362133 no 2719 0.217799158550875 3776 2967153
SGTC_216 k038-0035 28.382 µM -0.779749503539136 0.205875166575743 no 2720 0.217769167156013 3715 4444231 YPR107C YTH1
SGTC_920 mycophenolic acid 780.421 nM -0.78010423850516 0.205775271343226 no 2721 0.217664760916538 3825 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2059 5238311 157 µM -0.784764484185591 0.204465594621803 no 2722 0.216295833509219 3821 703021
SGTC_1109 tnp00067 928.257 nM -0.785249574777934 0.20432955446057 no 2723 0.216153627168476 3799 676295
SGTC_3064 1327-0027 10 µM -0.785278922858992 0.204321325731829 no 2724 0.21614502539277 3682 16000455 YPR107C YTH1
SGTC_215 1287-0124 461.5 µM -0.787348063113185 0.203741669616532 no 2725 0.215539070585443 3829 5560863
SGTC_1268 0828-0275 2.46 µM -0.789795176333474 0.203057393718827 no 2726 0.214823698287133 3883 745337
SGTC_1989 st071868 50.2 µM -0.790213408820212 0.202940582596621 no 2727 0.214701573234763 3808 16414057
SGTC_3317 9138495 8.753 µM -0.792815415506036 0.202214751668848 no 2728 0.213942686863535 3782 17020139
SGTC_2338 7999974 200 µM -0.795774666147944 0.201391157665862 no 2729 0.213081509586482 3875 315925
SGTC_3019 9081971 49.47 µM -0.795998768596429 0.201328869336417 no 2730 0.21301637557001 3834 16451803
SGTC_2343 7990716 14.84 µM -0.796441219277504 0.201205925950069 no 2731 0.212887814077928 3821 6456862
SGTC_998 3996-0085 177 µM -0.796475610452949 0.201196371589924 no 2732 0.212877823040168 3859 715391
SGTC_165 k038-0023 64.381 µM -0.796548046261022 0.201176248776939 no 2733 0.21285678048794 3829 46368543
SGTC_2976 9009005 19.48 µM -0.798789130385699 0.200554267557248 no 2734 0.212206347150155 3807 2993148
SGTC_1012 4112-3522 18 µM -0.799364262888234 0.200394834051703 no 2735 0.212039613082872 3794 3112398
SGTC_3349 9149703 23.001 µM -0.801117237645774 0.199909358688862 no 2736 0.211531888938704 3811 4910494
SGTC_3074 9116018 49.47 µM -0.803296800599435 0.199306729784653 no 2737 0.210901603369468 3879 17027303
SGTC_2761 levamisole 97.89 µM -0.805228425588391 0.198773568846637 no 2738 0.210343937977069 3799 26879 An alkaline phosphatase inhibitor.
SGTC_2517 totarol 10 µM -0.806732730607213 0.198358951586183 no 2739 0.209910241305358 3853 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1258 0671-0043 57.1 µM -0.808370267073751 0.197908206786125 no 2740 0.209438731473954 3879 4298767
SGTC_2842 9000675 19.48 µM -0.808711819389304 0.197814269866266 no 2741 0.209340464006914 3867 2989072
SGTC_2086 5274770 176.623 µM -0.809070375007874 0.197715685528284 no 2742 0.209237333746664 3895 689278
SGTC_2769 toremifene 3.73 µM -0.809720326330418 0.197537058080216 no 2743 0.209050466488468 3837 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2516 gossypol 71.55 µM -0.811181890439829 0.197135729977317 no 2744 0.208630611919989 3898 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2786 7743617 45.45 µM -0.811594017017088 0.19702265416317 no 2745 0.208512312746172 3805 583674
SGTC_528 3492-0019 172 µM -0.812546161529707 0.196761562941566 no 2746 0.208239155025099 3855 2869262
SGTC_2394 5221648 200 µM -0.813264517152296 0.196564718622402 no 2747 0.20803320806577 3939 788586
SGTC_2341 7987486 176.74 µM -0.813595794955245 0.196473981855721 no 2748 0.207938273823712 3871 1258686
SGTC_921 1561-0023 372 µM -0.813908637465002 0.196388317810511 no 2749 0.207848646069314 3826 24050882
SGTC_743 1275-0778 158 µM -0.813980110677016 0.196368749848111 no 2750 0.207828172567266 3852 2849257 YMR203W TOM40
SGTC_1263 0774-1208 64.8 µM -0.814741677057043 0.196160321315865 no 2751 0.207610095839181 3848 906585
SGTC_570 0987-0065 62.6 µM -0.815483183662377 0.195957511780159 no 2752 0.207397893257652 3662 3104428
SGTC_590 k048-0076 22.4 µM -0.815745692363441 0.195885743503612 no 2753 0.207322799890213 3839 6832814
SGTC_2134 5324836 1.464 µM -0.816344268593157 0.195722156073749 no 2754 0.207151631015335 3833 699272
SGTC_1820 st053765 18.6 µM -0.816785769182051 0.195601549666625 no 2755 0.20702543307833 3875 3690829
SGTC_1563 conessine 56.1 µM -0.819070729314734 0.194978079766544 no 2756 0.206373030423476 3928 441082 An anti-amoebic, histamine inhibitor.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.819116327188332 0.194965650326253 no 2757 0.206360023712586 3897 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_413 propylparaben 100 µM -0.819689713844618 0.194809393037475 no 2758 0.206196507672629 3822 7175 A pharmaceutical preservative.
SGTC_1101 ebselen 5.29 µM -0.820639268025963 0.194550791495809 no 2759 0.205925886718091 3874 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_732 3970-1727 52.7 µM -0.820951786015589 0.194465726076157 no 2760 0.205836865846793 3901 1275699
SGTC_2150 5556613 200 µM -0.821607590027376 0.194287293989845 no 2761 0.205650134062292 3866 743190
SGTC_2465 5809242 33.21 µM -0.823106195784153 0.19387992558101 no 2762 0.205223802880531 3885 2731748
SGTC_1513 0337-0559 19 µM -0.824936480458907 0.193383103123833 no 2763 0.204703826892907 3855 775073
SGTC_1015 4130-4525 82 µM -0.825511214143317 0.19322725467735 no 2764 0.204540709353877 3877 1363237
SGTC_3336 9143619 71.43 µM -0.82576941391581 0.193157264545504 no 2765 0.204467453797564 3863 45595730
SGTC_899 1083-0020 478 µM -0.826060463338532 0.193078388426441 no 2766 0.20438489697513 3941 767123
SGTC_369 0957-0393 4.5 µM -0.827022128392348 0.192817911362506 no 2767 0.204112259655933 3890 6997992
SGTC_544 k015-0020 52.4 µM -0.82846044223143 0.192428729853048 no 2768 0.203704894332527 3879 3008304
SGTC_1221 2958-7315 257 µM -0.828464751301103 0.19242756461941 no 2769 0.203703674628342 3887 4562705
SGTC_505 gw-5074 63.9 µM -0.832234464287426 0.191409834055083 no 2770 0.202638307016583 3922 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_857 0438-0306 1.35 µM -0.833693506526162 0.191016815248186 no 2771 0.202226859101943 3957 4686136
SGTC_663 1486-0733 13.9 µM -0.835621902809036 0.190498127630564 no 2772 0.201683821442046 3899 722445 YPR165W RHO1
SGTC_587 k089-0003 57 µM -0.836006313979599 0.190394834660642 no 2773 0.201575675504402 3792 9659696
SGTC_2675 theaflavin digallate 100 µM -0.83796225780214 0.189869796915787 no 2774 0.201025950477981 3847 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2222 6885208 172.143 µM -0.838011193025833 0.189856672564811 no 2775 0.201012208598742 3828 609514
SGTC_3132 9126706 49.47 µM -0.840781859523768 0.189114494212738 no 2776 0.200235075766241 3946 850858
SGTC_2269 7935389 174.42 µM -0.841068820620643 0.189037728196371 no 2777 0.200154690539877 3843 97605
SGTC_3302 9125395 16.351 µM -0.843176724794106 0.188474423518471 no 2778 0.199564806791453 3846 17599668
SGTC_2306 7482397 179.52 µM -0.843948525941297 0.188268430809685 no 2779 0.199349085028324 3870 891448
SGTC_3253 9135987 49.47 µM -0.844136376174031 0.188218314856648 no 2780 0.199296601328191 3858 4182430
SGTC_707 0865-0008 204 µM -0.84802469786947 0.187182811525437 no 2781 0.198212108135883 3902 723043
SGTC_2455 5377712 9.75 µM -0.848126411903575 0.187155771317452 no 2782 0.198183786934719 3901 2243908
SGTC_1895 st058434 18.3 µM -0.84819357778301 0.187137916901838 no 2783 0.1981650866425 3923 5393175
SGTC_854 0422-0053 192 µM -0.848535828965728 0.187046954109724 no 2784 0.198069813776295 3928 3596728
SGTC_3309 9129340 25.759 µM -0.849046816009478 0.186911195971315 no 2785 0.197927621195102 3943 17158987
SGTC_183 3914-0051 30.55 µM -0.850048054439156 0.186645365538882 no 2786 0.197649184987717 3941 1596232
SGTC_1983 st071813 46.9 µM -0.850090223129916 0.186634174822129 no 2787 0.19763746341792 3970 11838595
SGTC_1244 0416-0015 52.5 µM -0.850411804031518 0.186548847426336 no 2788 0.19754808786187 3887 96201
SGTC_1489 4065-0444 182 µM -0.854193881222844 0.185547135019467 no 2789 0.19649878645476 3862 2877968
SGTC_1477 0139-0234 16 µM -0.854826615490748 0.185379876986196 no 2790 0.196323570696987 3924 620880
SGTC_114 0364-0001 490.298 µM -0.85515143882252 0.185294049015372 no 2791 0.196233657944141 3970 4003655
SGTC_1311 1190-0148 100 µM -0.856446442134303 0.184952116015197 no 2792 0.195875442692843 3963 1961333
SGTC_1478 0453-0656 35.7 µM -0.856828983037652 0.18485118488302 no 2793 0.195769702723142 3925 5258496
SGTC_549 1661-1316 519 µM -0.857868794551715 0.18457700985897 no 2794 0.195482458548856 3907 2857282
SGTC_3054 9094397 49.47 µM -0.857952357020734 0.184554987289802 no 2795 0.19545938583565 3927 2598354
SGTC_1909 st060837 51.5 µM -0.860427718572598 0.183903356561223 no 2796 0.194776655891155 3934 678937
SGTC_395 anisomycin 6.25 µM -0.860756623882005 0.183816881297537 no 2797 0.194686049756786 3930 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_403 arphamenine a 50 µM -0.861362715491861 0.183657595003405 no 2798 0.194519152109923 3893 5487158 An arginine aminopeptidase inhibitor.
SGTC_1369 1866-0067 208 µM -0.862043798863028 0.183478702863491 no 2799 0.194331708147553 3887 3531355
SGTC_1516 st013856 110 µM -0.865195160403968 0.18265238658524 no 2800 0.193465840614712 3985 5281404 A mutagen and neurotoxin.
SGTC_2040 5100729 123 µM -0.865477775045528 0.182578396111529 no 2801 0.193388304630279 3923 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_64 000l-0018 272.079 µM -0.865946367705818 0.182455756557588 no 2802 0.193259786931038 3860 6811119
SGTC_2355 9061122 103.12 µM -0.86716842279326 0.182136163820483 no 2803 0.192924867563104 3951 5302957
SGTC_1926 methyl fluorone black 53.6 µM -0.869597861024393 0.181501855454265 no 2804 0.192260103560246 3709 72721 Reacts with homocysteine.
SGTC_1906 st060206 94.7 µM -0.869857132058801 0.181434243455861 no 2805 0.192189242399055 3958 5133468
SGTC_2978 9011784 42.97 µM -0.870009795598813 0.181394439647607 no 2806 0.192147525522279 3933 2994934
SGTC_851 0394-0702 453 µM -0.87124083140203 0.181073672763964 no 2807 0.191811334860875 3889 762646
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.876714977100931 0.179651600492921 no 2808 0.190320734880707 3932 390807
SGTC_1202 1988-0068 29.6 µM -0.877026152863913 0.179570974685848 no 2809 0.190236216555364 3902 2850480
SGTC_2061 5245884 80.95 µM -0.878013545627007 0.179315291287169 no 2810 0.18996818390278 3922 573863
SGTC_1731 st035964 63 µM -0.878334302322379 0.179232281263592 no 2811 0.189881162889379 3916 6739575
SGTC_2546 rhodinyl acetate 100 µM -0.880774983548628 0.178601438565328 no 2812 0.189219811238922 3847 6708682
SGTC_90 0870-0863 4.608 µM -0.882652777272704 0.178117038327327 no 2813 0.188711951875146 3938 1738164
SGTC_610 4215-0184 155 µM -0.884692561797083 0.177591789949765 no 2814 0.188161234255189 3966 5605015
SGTC_1277 0873-0036 22 µM -0.885240989982245 0.17745073555929 no 2815 0.188013334500883 4011 5965735
SGTC_739 1486-1183 203 µM -0.889015462048964 0.176481869776246 no 2816 0.186997385025768 3945 4346692
SGTC_922 1866-0035 480 µM -0.889481586137385 0.176362453365209 no 2817 0.186872157551335 3913 3156169
SGTC_2813 7971799 71.43 µM -0.890110090097078 0.176201517787728 no 2818 0.186703387781944 4008 2234054
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.892106262357677 0.175690991857978 no 2819 0.186167989298889 3950 688751
SGTC_1759 st043059 70 µM -0.89471088436595 0.175026264166655 no 2820 0.185470829388206 3985 669426
SGTC_805 3852-0218 479 µM -0.895721076865916 0.174768882125778 no 2821 0.185200875322348 3904 6615355
SGTC_219 mitoxanthrone 164.414 µM -0.896363344890961 0.174605366775893 no 2822 0.185029368792185 3929 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1338 1486-1223 76 µM -0.896705520885661 0.174518291689293 no 2823 0.184938036932729 3992 3444526
SGTC_2801 7907800 81.82 µM -0.898393010868694 0.174089271891822 no 2824 0.184488030630266 4006 6620925
SGTC_2470 5664817 21.68 µM -0.898465581866546 0.174070836818745 no 2825 0.184468693265358 3980 2859561
SGTC_2959 9079155 11 µM -0.898685338016311 0.174015020149433 no 2826 0.184410144438149 4026 16189457
SGTC_837 0091-0265 12.5 µM -0.899119015904079 0.17390490210406 no 2827 0.184294635147197 3917 759367
SGTC_1241 0364-0022 50.8 µM -0.899302330177512 0.17385836888112 no 2828 0.184245823274788 3990 4563895
SGTC_1960 st011366 51.8 µM -0.899413347983893 0.173830191530759 no 2829 0.18421626600259 3974 3972846
SGTC_654 1124-0271 80.9 µM -0.900095368850424 0.173657152035803 no 2830 0.184034750191416 3960 5403748
SGTC_1624 st003710 6.25 µM -0.903850158411629 0.172706465933758 no 2831 0.18303743042769 4011 24207033
SGTC_1235 benzylparaben 21.5 µM -0.904221030235279 0.17261274418878 no 2832 0.182939105478463 3988 7180
SGTC_69 0096-0274 206.684 µM -0.905258073128384 0.172350848792192 no 2833 0.182664341299004 4134 6741392
SGTC_603 3794-0023 45.9 µM -0.905274541115265 0.172346692003202 no 2834 0.182659980190668 3979 3802260
SGTC_1934 st074720 32.6 µM -0.905482313320006 0.172294252397478 no 2835 0.182604962833061 3926 17250992
SGTC_472 calcifediol 10 µM -0.907028190026743 0.171904408421288 no 2836 0.182195945049974 4011 5283731 A vitamin D metabolite.
SGTC_726 3448-4391 34.2 µM -0.908867261829688 0.171441359804066 no 2837 0.181710098334478 4096 1356692
SGTC_2234 tolnaftate 200 µM -0.909121411382152 0.171377431798111 no 2838 0.181643020812343 3975 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2682 pyrogallin 40.03 µM -0.909866857540323 0.171190012441041 no 2839 0.181446365093135 3991 822798 An ATP competetive kinase inhibitor.
SGTC_1889 st059080 5.18 µM -0.911124656439419 0.170874075116468 no 2840 0.181114848202449 3906 176925 Isolated from Daphnopsis sellowiana.
SGTC_1747 st037496 66.6 µM -0.913284499366065 0.170332430920406 no 2841 0.180546466265427 3996 723305
SGTC_3085 9117376 49.47 µM -0.91350979818328 0.170275994023721 no 2842 0.180487241375686 4080 16480349
SGTC_3314 9135860 59.4275 µM -0.913661119159602 0.170238095152018 no 2843 0.180447470076616 3975 25252478
SGTC_315 k915-0449 187 µM -0.914383883957119 0.170057150723292 no 2844 0.180257583533723 4005 20970215 YNL149C PGA2
SGTC_1888 azatryptophan 97.5 µM -0.915146951010906 0.169866250429226 no 2845 0.180057244823041 4034 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_487 nimodipine 119 µM -0.91779178602572 0.169205642812745 no 2846 0.179363941683379 3917 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2528 xanthyletin 44.79 µM -0.918215232741701 0.169100030763158 no 2847 0.179253097669573 4029 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_589 1227-0070 34.1 µM -0.918730829548441 0.168971492680111 no 2848 0.179118190057607 4043 2841384
SGTC_342 k048-0088 23.3 µM -0.918981603674979 0.168908997479997 no 2849 0.1790525972708 3981 6820570
SGTC_513 4245-1575 41.7 µM -0.922278139297735 0.168088851606723 no 2850 0.178191756887179 3915 719745
SGTC_2439 5492030 7.2 µM -0.922909983715204 0.1679319480224 no 2851 0.178027058679942 3980 5722370
SGTC_2624 nerol 100 µM -0.922982448004689 0.167913959261829 no 2852 0.178008176086991 3903 637566 A natural product oil.
SGTC_1239 0337-0584 35.4 µM -0.928883034538212 0.166453342762762 no 2853 0.176474853053362 4086 914301 YML130C ERO1
SGTC_1803 st050068 52.4 µM -0.92983383832271 0.166218752825329 no 2854 0.176228561594735 4067 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1203 3992-3522 103 µM -0.930020794043507 0.166172650745575 no 2855 0.176180159123957 4147 5322312
SGTC_1441 4106-0040 13 µM -0.934674604541561 0.165027713361237 no 2856 0.174978009174127 3998 2904180
SGTC_2357 9067248 200 µM -0.935857375037704 0.1647375423408 no 2857 0.174673313019033 4014 9150235
SGTC_1173 0443-0020 122 µM -0.936693659202212 0.164532574974318 no 2858 0.174458079406911 4008 5331295
SGTC_1245 0418-0076 17.2 µM -0.937636161625442 0.164301772447159 no 2859 0.174215710513604 4076 6790114
SGTC_2657 nystatin 74.44 µM -0.941119963730214 0.163450472675592 no 2860 0.173321692995458 4049 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1117 retinoic acid 1.10837 µM -0.941871858196102 0.163267116745802 no 2861 0.1731291248362 4064 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1910 st062352 60.4 µM -0.942794086897046 0.163042405902816 no 2862 0.172893118420743 3952 2245730
SGTC_1339 1486-1321 22.7 µM -0.945711779122878 0.162332803928736 no 2863 0.172147806454946 4035 3469382
SGTC_635 k038-0028 24.7 µM -0.946685810924743 0.162096361234771 no 2864 0.171899451414596 4030 4035102
SGTC_623 k072-0108 16.9 µM -0.947223595060194 0.16196591223044 no 2865 0.171762427275893 3992 5382803
SGTC_1138 3761-0006 1.03 µM -0.947508542563603 0.161896820924295 no 2866 0.171689852661475 4022 12061087
SGTC_1009 4106-0057 9.87 µM -0.948678897511206 0.161613246038304 no 2867 0.171391974971527 4017 2928005
SGTC_2319 6033012 152.6 µM -0.949463631110493 0.161423287951862 no 2868 0.171192430399891 3974 847246
SGTC_2013 4024628 200 µM -0.949466526593405 0.161422587320795 no 2869 0.171191694402419 4086 5230760
SGTC_2441 5730946 39.09 µM -0.951577759126725 0.160912252199912 no 2870 0.170655582736248 4087 1774275
SGTC_1417 3966-0327 90.4 µM -0.95192630430726 0.160828101938322 no 2871 0.170567179076732 4120 651118
SGTC_245 methotrexate 289.6 µM -0.954309560398926 0.160253475627863 no 2872 0.169963485053188 4013 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_364 0083-0097 67.7 µM -0.956555329632225 0.159713228320303 no 2873 0.169395872390411 4138 5207356
SGTC_3060 1327-0027 12.5 µM -0.956597996486076 0.159702975834657 no 2874 0.169385100237468 3940 16000455 YPR107C YTH1
SGTC_312 4092-0653 6.84 µM -0.956767284709245 0.159662301544436 no 2875 0.169342364164914 4003 1148278
SGTC_822 1487-0950 154 µM -0.957773989718073 0.159420564077633 no 2876 0.169088368846338 4060 1958375
SGTC_1282 0886-0010 32.4 µM -0.965329332240698 0.157613970822765 no 2877 0.167189942278397 4105 2836211 YNL267W PIK1
SGTC_693 4161-2696 114 µM -0.965511688733488 0.157570533607788 no 2878 0.167144292141381 4080 805759
SGTC_2719 novobiocin 32.65 µM -0.965851371300714 0.157489642383893 no 2879 0.167059279275064 4053 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_99 0109-0120 622.8 µM -0.966606148794716 0.157309999118407 no 2880 0.166870479803889 4031 759414
SGTC_825 1988-2224 89.6 µM -0.969192302772319 0.156695495095661 no 2881 0.166224625402273 4028 1180859
SGTC_659 k018-0002 107 µM -0.973980773827638 0.155561868322346 no 2882 0.165033042756547 4072 6797879 YHR007C ERG11
SGTC_1499 4480-0877 67.3 µM -0.97403573596583 0.155548888021735 no 2883 0.165019397936333 3980 2861909
SGTC_293 4049-0273 38.5 µM -0.974613764694596 0.155412419378833 no 2884 0.164875941604985 3925 1380311
SGTC_1355 1499-0035 1.68 µM -0.975733000166741 0.155148400165347 no 2885 0.164598397177788 4046 1548538
SGTC_954 1189-0853 2.85 µM -0.980113394812549 0.154117946873985 no 2886 0.163515073966826 4007 2828194
SGTC_1169 aniline yellow 25.8 µM -0.980313763755532 0.154070920192069 no 2887 0.163465631361016 3988 6051 A DNA damaging agent.
SGTC_1817 st052116 64.4 µM -0.981263588996411 0.153848124950383 no 2888 0.163231386668804 4082 4361398
SGTC_804 1595-0054 20.9 µM -0.98164743447122 0.153758148973009 no 2889 0.163136785099187 4002 761523 Stimulates phospholipase C.
SGTC_431 k089-0097 107 µM -0.981789324747693 0.153724897751688 no 2890 0.163101824208201 3895 5499420
SGTC_1394 3474-0001 65.7 µM -0.983371616768869 0.153354418699097 no 2891 0.16271228715397 4056 5017666 YIL048W NEO1
SGTC_2153 5569715 200 µM -0.98568603725946 0.15281358474871 no 2892 0.162143601651561 4093 2054701
SGTC_256 clotrimazole 625 nM -0.986744196749191 0.15256673583826 no 2893 0.161884028726513 4012 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1186 1319-0216 26 µM -0.988973486373233 0.152047550349205 no 2894 0.16133805700853 4136 4565136
SGTC_2541 muurolladie-3-one 83.07 µM -0.989978744685212 0.151813817251307 no 2895 0.161092254159325 4100 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_265 mycophenolic acid 32.932 µM -0.99138082439696 0.151488217926125 no 2896 0.160749830010721 4168 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1384 3089-0840 101 µM -0.997184909339624 0.150145300976439 no 2897 0.159337382233855 4085 1069836
SGTC_1480 1070-0044 41.2 µM -0.997582917152277 0.150053503782463 no 2898 0.159240824050166 4096 3124987
SGTC_194 1486-1323 56.904 µM -0.999505640949664 0.149610570609239 no 2899 0.158774903916756 4149 5178754
SGTC_2351 9026858 72.31 µM -1.00098093061282 0.149271303856128 no 2900 0.158418013855475 3991 1409300
SGTC_1262 0737-0114 49.6 µM -1.00518845419394 0.148306539296974 no 2901 0.157403056829257 4174 765919
SGTC_1968 st069590 43.6 µM -1.00628636819067 0.148055480740495 no 2902 0.157138917985284 4095 6384066
SGTC_2482 5981709 142.65 µM -1.00814923557586 0.147630152383023 no 2903 0.156691412048908 4049 877755
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.00934407398153 0.147357779080478 no 2904 0.156404824866656 4143 6708784 An antioxidant flavonoid
SGTC_2297 7971671 152.32 µM -1.01020999338839 0.147160596182465 no 2905 0.156197346209129 4119 909016
SGTC_2690 usnic acid 100 µM -1.0107519061447 0.147037284512526 no 2906 0.156067593472368 4138 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1628 st004252 77.7 µM -1.01082204116554 0.14702133042869 no 2907 0.15605080590513 4131 692968
SGTC_1561 5-methoxyflavone 52.9 µM -1.01331733522386 0.146454464463871 no 2908 0.155454304971628 4024 94525
SGTC_83 0170-0301 39.027 µM -1.01610928068945 0.145821948447118 no 2909 0.154788675039221 4092 3089716
SGTC_1845 st056753 3.01 µM -1.0185343132582 0.145274048736856 no 2910 0.154212051337851 4067 5375839
SGTC_1657 st012939 43.4 µM -1.02016166895144 0.144907149724992 no 2911 0.153825896659611 4136 24207257
SGTC_960 1222-0186 7.7 µM -1.02027636471464 0.144881314298223 no 2912 0.153798704705332 4154 3126296
SGTC_417 st075190 100 µM -1.021582406827 0.144587344694944 no 2913 0.153489293974872 4123 222757
SGTC_3345 9148410 3.559 µM -1.02479983749026 0.143864866794999 no 2914 0.152728821558879 4082 4903596
SGTC_2070 5230947 200 µM -1.028207137912 0.143102412917988 no 2915 0.151926200754111 4194 2835538
SGTC_2648 atorvastatin 78.68 µM -1.03274431329967 0.142091371105042 no 2916 0.15086178499412 4123 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2779 methotrexate 400 µM -1.0335648767106 0.141909038342192 no 2917 0.150669813200901 4143 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_393 acivicin 6.25 µM -1.03398906123106 0.141814844835767 no 2918 0.150570638534084 3982 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1284 0929-0043 16 µM -1.03758791335298 0.141017395019974 no 2919 0.149730973679583 4112 1239883
SGTC_117 lucigenin 22.078 µM -1.03861233423041 0.140790956387706 no 2920 0.149492533544958 4145 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3276 9139060 49.47 µM -1.03918859082182 0.140663688750627 no 2921 0.149358517783604 4209 4870619
SGTC_387 norethindrone acetate 66.7 µM -1.0393820690007 0.140620976148526 no 2922 0.149313539975995 4141 541197
SGTC_1692 fluoroquinolonic acid 71 µM -1.04004202431508 0.14047534941669 no 2923 0.149160188421789 4173 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2317 5986382 200 µM -1.04257857517731 0.139916583547251 no 2924 0.14857175815405 4153 877883
SGTC_1006 4099-6547 255 µM -1.04406807710855 0.139589172448541 no 2925 0.148226947043215 4174 3146833
SGTC_377 3970-0964 33.1 µM -1.04478816346789 0.139431075459881 no 2926 0.148060443337143 4091 16481235
SGTC_122 0236-0016 402.397 µM -1.04691807138829 0.138964161338046 no 2927 0.1475686831659 4125 6808838
SGTC_2478 5763493 32.33 µM -1.04709582006869 0.13892524381325 no 2928 0.147527693485418 4069 1365576 YLR208W SEC13
SGTC_2938 9059746 27.26 µM -1.04839612515219 0.138640771747033 no 2929 0.147228069035259 4140 6471769
SGTC_938 3126-1755 342 µM -1.04917375504238 0.138470836820205 no 2930 0.147049077729146 4145 1777771
SGTC_2791 5663188 71.43 µM -1.04978650158335 0.138337033767479 no 2931 0.14690814135014 4188 54690634
SGTC_1410 3909-8106 77.9 µM -1.05548906457163 0.137096014234599 no 2932 0.145600854107662 4205 1039210
SGTC_1131 3454-3128 32.3 µM -1.05557167175063 0.137078092925831 no 2933 0.145581974433969 4183 710982
SGTC_3247 9135149 49.47 µM -1.05631879062701 0.136916081068972 no 2934 0.145411296967461 4155 8934436 YOR116C RPO31
SGTC_3348 9149464 3.537 µM -1.05819519878488 0.136509761390568 no 2935 0.144983229857737 4098 1951442
SGTC_272 doxorubicin 8.13 µM -1.06164269189611 0.135765388477012 no 2936 0.144198962441724 4157 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1287 0971-0001 34.6 µM -1.06243690558701 0.135594298844513 no 2937 0.144018693517346 4139 4665869
SGTC_2877 9040724 71.43 µM -1.06300186532319 0.135472685079865 no 2938 0.143890552713727 4153 6463895
SGTC_2440 5628896 157.78 µM -1.06524146464519 0.134991322397636 no 2939 0.143383337047531 4143 5522048
SGTC_1199 1638-0010 4.46 µM -1.06569819338835 0.134893300736138 no 2940 0.143280047297646 4139 3111136
SGTC_1112 tnp00069 1.16933 µM -1.06712005174211 0.134588458706644 no 2941 0.14295881412151 4181 145826
SGTC_646 4092-0839 27.3 µM -1.06782503400299 0.134437488171475 no 2942 0.142799721700842 4190 877796
SGTC_2273 7815444 169.05 µM -1.07037746482126 0.133891862996057 no 2943 0.142224719302963 4116 2824616
SGTC_2216 7189485 200 µM -1.07041695011239 0.133883434319734 no 2944 0.142215836522688 4168 731273
SGTC_3063 1327-0034 4 µM -1.0709014097444 0.133780049459256 no 2945 0.142106880968707 4056 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1656 st012921 11 µM -1.07252550266857 0.133433864517151 no 2946 0.141742032776457 4083 6732821
SGTC_2618 avocadyne 43.43 µM -1.07509829799226 0.13288672026644 no 2947 0.141165360704709 4077 3015189
SGTC_2694 st077685 81.9 µM -1.07859421907501 0.132145737845191 no 2948 0.140384329753921 4114 2838096
SGTC_1875 nocodazole 6 µM -1.07945234250409 0.131964289493231 no 2949 0.140193064008661 4195 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_401 neomycin 50 µM -1.08390616544093 0.13102529909027 no 2950 0.139203202843209 4141 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_673 1082-0474 110 µM -1.08682606875034 0.130412212837287 no 2951 0.13855684227224 4188 3098046
SGTC_3168 9103419 49.47 µM -1.08732651774762 0.130307334072123 no 2952 0.138446266641819 4179 16649256
SGTC_586 0957-0265 8.15 µM -1.08778589723002 0.130211113594792 no 2953 0.138344818389032 4056 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2612 dictamnine 15.46 µM -1.09355972007879 0.129005934379012 no 2954 0.137074061698623 4134 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_868 0527-0199 213 µM -1.09459326256495 0.128791020306795 no 2955 0.136847434294269 4144 2849450
SGTC_2934 9036370 36.88 µM -1.09466826121258 0.128775434813863 no 2956 0.136830999128454 4174 6462800
SGTC_777 1315-0167 517 µM -1.0952574267448 0.128653045648781 no 2957 0.136701936621322 4218 4221767
SGTC_670 4204-0025 119 µM -1.09548842234992 0.128605082256189 no 2958 0.136651357481732 4198 719039
SGTC_3179 9107801 49.47 µM -1.09629034295956 0.128438669639237 no 2959 0.136475867086188 4178 4818259
SGTC_1043 0916-0009 19.3 µM -1.09634189494771 0.128427976811797 no 2960 0.136464590847649 4225 3101130
SGTC_3318 9139014 38.6185 µM -1.09649070476909 0.128397114393291 no 2961 0.136432044464692 4186 16643984
SGTC_867 0518-0118 155 µM -1.09835215752648 0.128011493321841 no 2962 0.136025372404504 4165 6848158
SGTC_678 1218-2179 85.9 µM -1.1005313757585 0.127561066768733 no 2963 0.135550333411457 4200 6820081 YOR116C RPO31
SGTC_3026 9090633 49.47 µM -1.10357870798688 0.12693305785275 no 2964 0.134887965804211 4197 25236842
SGTC_812 4251-0442 148 µM -1.10438437781972 0.126767381854401 no 2965 0.134713217291333 4231 5723007
SGTC_2895 9054447 58.44 µM -1.10530388525274 0.126578480621268 no 2966 0.134513967489153 4261 2697450
SGTC_2074 5212007 75.395 µM -1.10547796792812 0.126542739610735 no 2967 0.134476267973422 4098 758611
SGTC_706 4262-0057 46.9 µM -1.10606865244341 0.126421518242459 no 2968 0.134348402819571 4206 883298
SGTC_1424 4048-1941 275 µM -1.10614330751947 0.126406203150632 no 2969 0.134332248220729 4270 X1424
SGTC_2924 9010168 62.78 µM -1.10638350978774 0.126356935703625 no 2970 0.134280279944728 4271 2993929
SGTC_1844 rapamycin 4 nM -1.10672755255989 0.126286393030798 no 2971 0.134205869606757 4095 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1 0258-0098 57.368 µM -1.10753277128232 0.126121397951381 no 2972 0.134031825836537 4144 6790032 YDR047W HEM12
SGTC_1941 st076221 61.8 µM -1.11188815188965 0.125231554158562 no 2973 0.133093121765322 4085 2828568
SGTC_3342 9147791 14.508 µM -1.11254295451895 0.12509815204682 no 2974 0.132952386072321 4131 1838168
SGTC_1583 clindamycin 39.6 µM -1.1187952079033 0.12382938534924 no 2975 0.131613758276567 4180 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_939 1165-0479 45.3 µM -1.11893068787292 0.123801992537684 no 2976 0.131584854908727 4193 1377347
SGTC_193 1273-0060 1.558 µM -1.11894997158027 0.123798093893205 no 2977 0.131580741268662 4039 2847393 YHR072W ERG7
SGTC_344 k064-0035 6.43 µM -1.11898468617706 0.123791075756535 no 2978 0.131573336103288 4153 5088750
SGTC_235 0330-0087 5 mM -1.12036262776485 0.123512726723963 no 2979 0.131279631944126 4242 46494818 YHR062C RPP1
SGTC_2940 9060638 45.86 µM -1.12069711261655 0.123445225782858 no 2980 0.131208405834094 4204 4027022
SGTC_1023 4482-3888 16 µM -1.12115123821651 0.123353622024772 no 2981 0.131111745823388 4225 3303168
SGTC_2068 5226020 147 µM -1.12367446883508 0.122845517044972 no 2982 0.130575575659951 4239 1810509
SGTC_483 fpl-64176 144 µM -1.12656003807086 0.122266248737056 no 2983 0.129964271519455 4318 3423
SGTC_555 4296-0685 37 µM -1.12857816407976 0.121862257916179 no 2984 0.12953791320118 4193 2908540 YHR072W ERG7
SGTC_1763 st044482 94.5 µM -1.1286958496299 0.12183872845539 no 2985 0.129513080361483 4201 88505
SGTC_1855 st056195 39.6 µM -1.13080385016892 0.121417805880586 no 2986 0.12906882953757 4165 4028379
SGTC_1436 4092-1007 8.32 µM -1.13120331760521 0.121338156151872 no 2987 0.128984762952353 4218 2881121
SGTC_1658 st012944 20 µM -1.13138812038323 0.121301320797148 no 2988 0.12894588467558 4075 24207260
SGTC_983 1491-0821 12.2 µM -1.13215125199929 0.121149294766342 no 2989 0.128785425319582 4216 46495113
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.13232503256717 0.121114694094107 no 2990 0.128748904837323 4208 803109
SGTC_1396 3511-0007 98.6 µM -1.13427210185147 0.120727497045839 no 2991 0.128340213873654 4239 X1396
SGTC_2778 tioconazole 65.09 nM -1.13619620414135 0.120345724061269 no 2992 0.127937229407652 4124 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2282 7944268 200 µM -1.13759142429918 0.120069422273561 no 2993 0.127645564601387 4251 2970414
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.13963002642104 0.119666512969739 no 2994 0.127220235194494 4202 689007
SGTC_459 nigericin 15.3 µM -1.14042423720607 0.119509803553488 no 2995 0.127054800016824 4304 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_617 3770-0098 35 µM -1.14119963351009 0.119356946235872 no 2996 0.126893428414066 4142 5962639
SGTC_233 rapamycin 362 pM -1.14148302554872 0.119301114345241 no 2997 0.126834485896698 4224 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_268 camptothecin 39.6153 µM -1.14153853504166 0.119290180417475 no 2998 0.126822942747867 4210 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1081 sertraline 6 µM -1.14363007309112 0.118878717014625 no 2999 0.126388542187033 4226 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_199 4063-0024 41.6 µM -1.14650727625958 0.118314330946977 no 3000 0.125792659139706 4245 306215
SGTC_374 0880-0231 82.3 µM -1.14783584764865 0.118054361522316 no 3001 0.125518167804667 4127 6833587
SGTC_3259 9138485 49.47 µM -1.15059129724724 0.117516474965734 no 3002 0.124950207487208 4248 17646153
SGTC_2433 5607874 27.82 µM -1.15134332509473 0.117369974778008 no 3003 0.124795509932117 4207 2252428
SGTC_838 0109-0203 71.4 µM -1.1601088079269 0.115671932589588 no 3004 0.123002254268458 4278 759422
SGTC_3186 9110464 49.47 µM -1.16155385842165 0.115393682630063 no 3005 0.122708366971728 4251 17018021
SGTC_3245 9134821 49.47 µM -1.16349752668333 0.115020172604332 no 3006 0.122313850515967 4272 17014901
SGTC_688 0527-0193 473 µM -1.16488243812927 0.114754562605768 no 3007 0.122033291579169 4299 4007154
SGTC_452 diindolylmethane 8 µM -1.1649056188615 0.114750120525866 no 3008 0.122028599415352 4245 3071 Inhibits expression of several cancer promoting factors.
SGTC_2536 dehydroabietamide 32.04 µM -1.16639672988268 0.114464638741137 no 3009 0.12172704003614 4354 3983547
SGTC_1525 8-methoxypsoralen 92.5 µM -1.17364674531788 0.113083786907195 no 3010 0.120268274668355 4318 4114 Related to psoralen; DNA damaging agent.
SGTC_1469 k284-2957 126 µM -1.17364779862815 0.113083587159132 no 3011 0.120268063631955 4257 23884841
SGTC_1954 st077032 68.9 µM -1.17741153265457 0.112371445758353 no 3012 0.119515644495857 4221 698907
SGTC_952 1185-0122 232 µM -1.17793245001922 0.112273135251421 no 3013 0.119411768563215 4221 678600
SGTC_1994 st072947 40.9 µM -1.17808064917597 0.112245177492248 no 3014 0.11938222786909 4318 5286565 YDL195W SEC31
SGTC_493 zm226600 134 µM -1.17900532089142 0.112070850612073 no 3015 0.119198028542277 4292 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2963 9082507 9 µM -1.18251485902521 0.111410964595757 no 3016 0.11850073658779 4294 16459611
SGTC_2018 5133068 143 µM -1.18271268729152 0.111373850620091 no 3017 0.118461517125456 4221 785362
SGTC_1860 st056228 74.6 µM -1.18302177463432 0.111315881374331 no 3018 0.118400258912772 4252 688679
SGTC_1604 st002052 72.4 µM -1.18562866918547 0.110827818191947 no 3019 0.117884487623209 4351 6254834 YHR062C RPP1
SGTC_1102 cgs 12066b 26.1 µM -1.18592354612237 0.110772707958048 no 3020 0.117826246768129 4279 6438352 A 5-HT1B full agonist.
SGTC_893 0958-0369 48.9 µM -1.18666976151584 0.110633333760545 no 3021 0.117678953460248 4183 6819948
SGTC_94 0334-0113 514.748 µM -1.19135199861647 0.109761678024936 no 3022 0.11675771428263 4295 6795178
SGTC_912 3474-0017 2.18 µM -1.19203483083425 0.109634973473921 no 3023 0.116623794089053 4316 3360550
SGTC_3324 9138759 60.749 µM -1.19212015856707 0.109619147668386 no 3024 0.116607066881091 4317 45595710
SGTC_3035 9091303 49.47 µM -1.19228787148761 0.109588046594006 no 3025 0.116574194265052 4354 25237002
SGTC_1674 st016616 23.6 µM -1.19256626391792 0.109536434842183 no 3026 0.116519642391876 4220 625830
SGTC_956 1185-0240 191 µM -1.19683887180826 0.108746515917431 no 3027 0.11568468195233 4262 1416193
SGTC_3009 9080819 71.4286 µM -1.19859146051657 0.108423685246098 no 3028 0.115343420144173 4305 17027216
SGTC_928 2764-0428 58.7 µM -1.19952834898235 0.1082513914497 no 3029 0.115161284192207 4303 662578
SGTC_2186 6124449 200 µM -1.19990216698749 0.108182701342326 no 3030 0.115088669143636 4287 3834182 YLR033W RSC58
SGTC_121 0557-0495 61.343 µM -1.20006208994515 0.108153324634404 no 3031 0.115057613669372 4366 3104427
SGTC_1616 st002734 56.1 µM -1.2015068638145 0.107888190217905 no 3032 0.114777322789177 4219 4026101
SGTC_1701 st028638 40.4 µM -1.20422497075998 0.107390652336265 no 3033 0.114251318515305 4293 3490878
SGTC_232 clozapine 119 µM -1.2050658736782 0.107237064147734 no 3034 0.114088936382721 4272 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2092 5303694 80.6725 µM -1.20507241457134 0.107235870095914 no 3035 0.114087673951543 4282 1963699
SGTC_2253 7938677 135.83 µM -1.20634033452423 0.107004590029115 no 3036 0.113843145768402 4349 2301972
SGTC_3267 9137951 49.47 µM -1.20709681361351 0.106866772889766 no 3037 0.113697430935764 4320 16643986
SGTC_2809 7964133 12.99 µM -1.20857461058497 0.106597913912508 no 3038 0.113413157755026 4295 1253665
SGTC_488 nitrendipine 139 µM -1.21022500337618 0.106298231690404 no 3039 0.113096283137737 4325 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1184 1269-1718 139 µM -1.2104125125335 0.106264221865735 no 3040 0.113060321476591 4336 5403821
SGTC_200 k038-0079 37.545 µM -1.21269710488871 0.105850480720272 no 3041 0.112622823566717 4270 3436683
SGTC_2600 tangeritin 87.95 µM -1.21454447057476 0.105516773992815 no 3042 0.112269939430998 4215 68077 A bioactive flavone.
SGTC_3248 9135562 49.47 µM -1.21533140118403 0.105374854768027 no 3043 0.112119860035347 4265 17650701
SGTC_2430 5571206 200 µM -1.21597150010176 0.105259517824426 no 3044 0.111997889442482 4297 1731771
SGTC_156 3474-0145 5.642 µM -1.22018533546904 0.104502522475893 no 3045 0.111197312349133 4200 2265471
SGTC_1116 jasmonic acid 1.58368 µM -1.22207929130001 0.104163570170569 no 3046 0.110838821752557 4354 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1605 st000082 49.1 µM -1.22503408499139 0.103636357496362 no 3047 0.110281189179825 4270 1114022
SGTC_1670 st016595 4.04 µM -1.22596467779901 0.103470716945491 no 3048 0.11010598379232 4322 597879
SGTC_340 k038-0059 454 µM -1.2264303855775 0.103387895626267 no 3049 0.110018378655946 4274 23733424
SGTC_471 1-acyl-paf 4 µM -1.22893400880195 0.102943476762334 no 3050 0.109548274601779 4260 16759367
SGTC_1465 k213-0056 144 µM -1.22919773922679 0.102896742821144 no 3051 0.109498838178278 4206 24048857 YMR208W ERG12
SGTC_2247 cerulenin 830 nM -1.23133099238292 0.102519289515022 no 3052 0.109099547465039 4363 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2002 4023503 131 µM -1.23172979701303 0.102448837693132 no 3053 0.10902501762655 4307 4736863 YCR052W RSC6
SGTC_3120 9124077 49.47 µM -1.23606244268827 0.101685711130044 no 3054 0.108217676972617 4448 18774327 YGL155W CDC43
SGTC_1520 flindersine 88 µM -1.23649839334296 0.10160915514204 no 3055 0.108136681286566 4370 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3177 9107506 49.47 µM -1.24069011691009 0.100875200124292 no 3056 0.107360123332896 4270 8897194
SGTC_3029 9088683 49.47 µM -1.24961219025032 0.0993258640799898 no 3057 0.10572062393254 4356 25236615
SGTC_1524 corynanthine 62.1 µM -1.2510390209609 0.0990797143490567 no 3058 0.105460120657848 4407 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2120 5538279 151.968 µM -1.25291361044755 0.0987569980607172 no 3059 0.105118574040836 4291 2058197
SGTC_2864 9034755 47.6 µM -1.25391846070728 0.0985843270394863 no 3060 0.104935822153537 4256 4930451
SGTC_541 4513-1321 94 µM -1.2615910393255 0.0972731712742788 no 3061 0.103547991089572 4295 747515
SGTC_3249 9135183 49.47 µM -1.26173436346346 0.0972488011500138 no 3062 0.10352219368612 4308 4902779
SGTC_3222 9128301 49.47 µM -1.26755893588829 0.096262206733024 no 3063 0.102477752144103 4325 4911358
SGTC_2700 st077718 96.8 µM -1.26760457352114 0.0962545055643398 no 3064 0.102469598928742 4325 904970
SGTC_3194 9111903 49.47 µM -1.27044884604466 0.095775439079873 no 3065 0.101962396654088 4363 17087251
SGTC_1479 0549-0158 134 µM -1.2720202250175 0.0955115219640653 no 3066 0.10168296667267 4409 5440202
SGTC_1076 itraconazole 331 nM -1.27232528836512 0.0954603478953368 no 3067 0.101628783566806 4343 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_20 0481-0013 4.944 µM -1.27295959230069 0.0953540086613053 no 3068 0.10151619047976 4391 182045
SGTC_3274 9138298 49.47 µM -1.27353090922881 0.0952583036879817 no 3069 0.101414855786081 4322 17015756
SGTC_1288 0973-0013 65.5 µM -1.27423974331742 0.09513966066674 no 3070 0.101289232069922 4383 4315430
SGTC_1793 st048256 72.231 µM -1.27460655405508 0.0950783074736266 no 3071 0.101224268262678 4295 672022
SGTC_1472 k841-0093 193 µM -1.27873127515182 0.0943904070083489 no 3072 0.100495851152162 4468 X1472
SGTC_608 k048-0125 159 µM -1.27890295063554 0.0943618555909703 no 3073 0.10046561673745 4382 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2663 amphotericin b 100 µM -1.27919062502227 0.0943140266289273 no 3074 0.100414968199468 4365 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_425 3825-7017 13.1 µM -1.27919536107663 0.0943132393585617 no 3075 0.100414134516027 4385 3397440
SGTC_3136 9095672 49.47 µM -1.27954137660136 0.0942557345978566 no 3076 0.100353239374016 4186 17217380
SGTC_3240 9133527 49.47 µM -1.28279375402428 0.0937164813580765 no 3077 0.0997821714796397 4305 17617455
SGTC_1080 nisoldipine 24.4 µM -1.28550522958197 0.0932686549541276 no 3078 0.0993078952291349 4359 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1952 st077036 64.1 µM -1.29267265308276 0.0920925025440134 no 3079 0.0980621499363136 4375 2937007
SGTC_894 0960-0238 55.9 µM -1.29289689331185 0.0920558833708376 no 3080 0.0980233610736069 4356 6741907 YDL195W SEC31
SGTC_496 calpeptin 138 µM -1.29330951010722 0.0919885298525297 no 3081 0.0979520163898046 4352 73364 A calpain inhibitor.
SGTC_2111 5486399 200 µM -1.2993851197358 0.0910009983760427 no 3082 0.0969058978692668 4306 689674
SGTC_2363 9053361 176 µM -1.30651268092981 0.0898525324870341 no 3083 0.0956891347492045 4419 6469797 YMR079W SEC14
SGTC_568 1193-0097 7.48 µM -1.3071441510094 0.0897513053906891 no 3084 0.0955818794694672 4171 3646150
SGTC_1830 st055982 50.3 µM -1.30814046365114 0.0895917650583322 no 3085 0.0954128355770145 4352 455313 An antimicrobial agent.
SGTC_252 miconazole 1.30953 nM -1.3095227957764 0.0893707605220302 no 3086 0.0951786605759278 4268 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1531 st059297 52.4 µM -1.31032503819755 0.089242685699978 no 3087 0.0950429503413239 4395 7566702
SGTC_97 0535-0701 19.132 µM -1.3123714632281 0.0889166006185641 no 3088 0.0946974152733369 4266 2832013 YGL099W LSG1
SGTC_1992 st073643 23.3 µM -1.31502843554883 0.0884945531778737 no 3089 0.0942501730072939 4355 3161292
SGTC_201 4262-0159 12.803 µM -1.31510787575926 0.0884819574959758 no 3090 0.0942368250413615 4413 1341029
SGTC_2889 9059656 51.95 µM -1.3177277136344 0.0880673158165421 no 3091 0.0937974068821306 4441 3949838
SGTC_1448 4255-0083 152 µM -1.3214763694806 0.0874765380743662 no 3092 0.0931712883256467 4411 5399660
SGTC_500 h-89 112 µM -1.32229909731844 0.0873472751801491 no 3093 0.0930342866236911 4360 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1227 3909-8010 46.6 µM -1.32880918408064 0.0863294669377007 no 3094 0.0919554657107953 4375 15982272
SGTC_567 1080-0542 68.4 µM -1.32935634106384 0.0862443283630615 no 3095 0.0918652172328581 4273 5950415
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.33279583143309 0.0857105753504876 no 3096 0.0912994070452123 4344 688761
SGTC_1800 st050079 29.0735 µM -1.33479340870652 0.0854017211206828 no 3097 0.0909719856819682 4214 3645560
SGTC_2656 pseudo-anisatin 100 µM -1.33809288833851 0.0848934008216299 no 3098 0.0904330793759633 4443 6708809 A neurotoxin.
SGTC_3126 9127922 49.47 µM -1.33866982824759 0.0848047504981589 no 3099 0.0903390913618188 4392 45595682
SGTC_2231 micatex 6.853 µM -1.34181533149372 0.0843226453141861 no 3100 0.0898279399355015 4421 20737 An antifungal of unknown mechanism.
SGTC_427 1354-0053 47.3 µM -1.34448796072659 0.0839146352554315 no 3101 0.0893953234883273 4441 6813657
SGTC_2708 st078559 56 µM -1.34505699225769 0.083827957272925 no 3102 0.0893034152363385 4348 17250902
SGTC_2807 7945238 51.95 µM -1.34691956126398 0.0835447108992793 no 3103 0.0890030703716308 4384 17148797
SGTC_153 4077-0274 519.67 µM -1.34946163234917 0.0831592920456242 no 3104 0.0885943680136903 4438 3121976
SGTC_1167 k781-0610 148 µM -1.34954396098024 0.0831468320908087 no 3105 0.0885811550096172 4432 4525169
SGTC_1827 berberine 7.24 µM -1.35869512293512 0.0817705909431271 no 3106 0.0871216090956896 4304 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1773 st048542 73.5835 µM -1.35891448072966 0.081737813784894 no 3107 0.0870868448169893 4382 3237138
SGTC_1930 st074634 34.3 µM -1.36275631778731 0.0811653585102322 no 3108 0.0864796610871313 4325 684253 YOR116C RPO31
SGTC_728 3030-5151 22.5 µM -1.36342337967335 0.0810662715356902 no 3109 0.0863745584531626 4490 3125388
SGTC_1962 st076595 64.5 µM -1.37290844654291 0.0796671982085611 no 3110 0.084890405206149 4385 279619
SGTC_3171 9103192 49.47 µM -1.37483610222536 0.0793851105035632 no 3111 0.0845911313795473 4507 13018434
SGTC_217 ketoconazole 989 nM -1.38239235743204 0.0782866362941739 no 3112 0.0834256307304854 4236 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_695 3505-6186 243 µM -1.38290573749865 0.0782124250553402 no 3113 0.0833468854201981 4420 1819379
SGTC_197 4544-0043 41.561 µM -1.39404008576593 0.0766160058728428 no 3114 0.0816527500317483 4445 896523
SGTC_1873 rapamycin 2 nM -1.40032552087021 0.0757258240685327 no 3115 0.0807079309240235 4384 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2265 7929201 200 µM -1.40220734846727 0.0754608465251322 no 3116 0.0804266689552612 4420 1265108
SGTC_1581 himbacine 57.9 µM -1.40252480795794 0.0754162152341298 no 3117 0.0803792938737497 4436 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3066 9117245 49.47 µM -1.40579894106897 0.0749570814192429 no 3118 0.0798919182973343 4483 17176980
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.4064425648063 0.0748670769240208 no 3119 0.0797963741903318 4385 97141
SGTC_2348 9022543 33.42 µM -1.41528441339267 0.0736389622661591 no 3120 0.0784925615508147 4448 3162678 YDL140C RPO21
SGTC_1965 Pectolinarigenin 58.4 µM -1.41822121372208 0.0732344724456476 no 3121 0.0780630951517292 4427 5320438 An anti-inflammatory.
SGTC_3078 9116413 49.47 µM -1.4216020757531 0.0727709286185179 no 3122 0.0775709009261469 4396 17177322
SGTC_1504 k297-0033 30 µM -1.42175988268411 0.0727493470017062 no 3123 0.0775479846961111 4338 4388117
SGTC_2890 9046729 58.44 µM -1.42199968880309 0.0727165605894243 no 3124 0.0775131706417573 4415 903329
SGTC_1377 2944-0135 198 µM -1.42219412338329 0.072689985703675 no 3125 0.0774849521522004 4458 1894137
SGTC_1118 chelidonine 707.474 nM -1.42852010422843 0.0718294160957221 no 3126 0.0765711061112333 4443 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2511 berberine 10.47 µM -1.43331623365875 0.0711821876285535 no 3127 0.0758837424007347 4441 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_696 1560-0013 611 µM -1.43475891577125 0.0709883790880258 no 3128 0.07567790451144 4489 1650269
SGTC_1950 st077106 7.18 µM -1.43503418424957 0.0709514458695658 no 3129 0.0756386783337658 4371 13831864
SGTC_221 trifluoperazine 10.304 µM -1.43701782827634 0.0706857333997881 no 3130 0.075356463911299 4444 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1385 3091-4834 14.1 µM -1.44405593649453 0.0697491340570384 no 3131 0.0743616207229203 4447 4072814
SGTC_172 1112-0046 2.638 µM -1.44520378659896 0.069597293594492 no 3132 0.0742003265586163 4440 2802135 YIL048W NEO1
SGTC_3059 1327-0034 3 µM -1.45173305325202 0.0687384227351834 no 3133 0.0732879224922283 4311 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1660 st012960 28.1 µM -1.45181984230764 0.0687270616464464 no 3134 0.0732758525944459 4494 24207266
SGTC_2239 6685329 187.64 µM -1.45384779748602 0.0684620049449994 no 3135 0.0729942542159498 4490 805680
SGTC_823 0417-1665 178 µM -1.45673475573843 0.0680860366217005 no 3136 0.0725948059642603 4485 3429856
SGTC_1666 st014829 29 µM -1.4591445275869 0.067773434422462 no 3137 0.0722626664537292 4471 3858230
SGTC_2716 st080858 38.6235 µM -1.45957606013858 0.0677175720611501 no 3138 0.0722033113454365 4459 5296050
SGTC_3107 9121808 49.47 µM -1.46452603488641 0.0670793337764813 no 3139 0.0715251374421808 4428 662681
SGTC_1572 epiandrosterone 68.9 µM -1.46733025431686 0.066719834067802 no 3140 0.0711431186956854 4423 441302 A steroid.
SGTC_1607 st000305 50.6 µM -1.467841975623 0.0666543927759251 no 3141 0.0710735762615155 4493 5457690
SGTC_574 1315-0397 40 µM -1.46867735373059 0.066547667509096 no 3142 0.0709601613673215 4467 6794277
SGTC_2477 5967686 25.23 µM -1.47138662130704 0.0662024500665814 no 3143 0.0705932947248305 4461 776118
SGTC_986 1493-0483 84 µM -1.47235116791629 0.0660798819946504 no 3144 0.0704630362627503 4434 40079
SGTC_1833 st055984 71 µM -1.47557524937761 0.0656714631407906 no 3145 0.0700289767829713 4502 676288
SGTC_1267 0828-0272 9.49 µM -1.47805909698772 0.065358152080228 no 3146 0.0696959804820869 4537 745334
SGTC_352 k048-0007 5.11 µM -1.47916526003634 0.0652189950433211 no 3147 0.0695480759321023 4417 6811911
SGTC_301 4119-0100 24.5 µM -1.48169450229315 0.0649016762376139 no 3148 0.069210800297955 4499 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_682 0kpi-0099 17 µM -1.48206505773279 0.0648552871761773 no 3149 0.0691614925760053 4492 1714895 YML126C ERG13
SGTC_3209 9113616 49.47 µM -1.48253474476896 0.0647965250362291 no 3150 0.0690990328745804 4513 16649353
SGTC_2949 9072542 2.23 µM -1.4826253468442 0.0647851946466216 no 3151 0.069086989474612 4462 16457352
SGTC_2270 7924575 90.91 µM -1.48413803666129 0.0645962499462211 no 3152 0.0688861520715963 4457 1262135
SGTC_1556 plumbagin 1.48 µM -1.48994797416496 0.0638745281505585 no 3153 0.0681189579866786 4423 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_563 tetrahydrosecaminediol 614 µM -1.49049224283923 0.0638072405847417 no 3154 0.0680474273024681 4534 334274 A psychoactive constituent of the cannabis plant.
SGTC_2328 6201408 200 µM -1.4934837197236 0.0634383901962113 no 3155 0.067655306351143 4449 2890418
SGTC_2714 st079313 56.9 µM -1.49505814380743 0.0632449307263886 no 3156 0.0674496341574273 4481 2939799
SGTC_524 r073-0010 27.8 µM -1.49701850494928 0.0630046911388594 no 3157 0.0671942215457836 4423 2772106
SGTC_2027 5150920 200 µM -1.49797033570959 0.0628883022219819 no 3158 0.0670704788976764 4446 786715
SGTC_1272 0839-0021 27 µM -1.49843316749848 0.0628317681750844 no 3159 0.0670103722218046 4524 5027250
SGTC_3316 9136639 10.545 µM -1.50103116374472 0.062515162429708 no 3160 0.0666737506772275 4480 4903665
SGTC_1957 st077035 62.4 µM -1.50176087428064 0.0624264600948589 no 3161 0.0665794381126695 4514 705593
SGTC_3014 9081533 49.47 µM -1.50389491563664 0.0621676128805304 no 3162 0.0663042131867173 4519 21367265
SGTC_1368 1852-0141 284 µM -1.50403580632806 0.06215055313937 no 3163 0.0662860737223627 4473 2838987
SGTC_2904 7225135 42.03 µM -1.50540140153354 0.0619853893161793 no 3164 0.0661104544920791 4558 4446116
SGTC_48 0382-0018 55 µM -1.51156198597242 0.0612445432081912 no 3165 0.0653226642200998 4525 762596
SGTC_1219 1469-0211 33.1 µM -1.51397348806999 0.0609564372920434 no 3166 0.0650162818874187 4498 6822282
SGTC_2344 7990960 76.95 µM -1.51484571345869 0.0608524924738567 no 3167 0.0649057403723759 4483 140813
SGTC_2388 9080168 200 µM -1.51598256679688 0.0607172195302843 no 3168 0.0647618803120412 4521 15943073
SGTC_2212 7123476 200 µM -1.52021142823407 0.0602160955403261 no 3169 0.0642289230356958 4540 1085715
SGTC_1324 1418-0026 34.4 µM -1.52022088891946 0.0602149780812056 no 3170 0.0642277345526836 4529 1372513
SGTC_2236 dapsone 200 µM -1.52057075483765 0.0601736646879959 no 3171 0.0641837952263156 4530 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_809 3998-0021 90 µM -1.5242489109411 0.0597406769226471 no 3172 0.0637232720390916 4464 715485
SGTC_1422 4031-0024 15.5 µM -1.52544364515865 0.0596005607884618 no 3173 0.0635742398245871 4450 782427
SGTC_185 k048-0037 25.491 µM -1.52627176934999 0.0595035911892461 no 3174 0.063471098125092 4555 6827589
SGTC_228 caffeine 993.056 µM -1.52949804687036 0.0591269875677981 no 3175 0.063070511441924 4505 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1688 st021091 57.6 µM -1.53083394246636 0.0589715967506504 no 3176 0.062905219247134 4541 3656366
SGTC_1310 1188-0297 994 nM -1.53255522859422 0.0587718500533035 no 3177 0.0626927399580589 4394 1588352
SGTC_2846 9008642 19.48 µM -1.53351142828101 0.0586611174751025 no 3178 0.0625749465048946 4518 2992898
SGTC_720 r052-1644 49.9 µM -1.53632454556236 0.0583362943035374 no 3179 0.0622294011869537 4523 1422863 YOR257W CDC31
SGTC_1780 st038448 24.544 µM -1.53967244164876 0.0579515646326013 no 3180 0.0618201087869999 4528 728868 YDL195W SEC31
SGTC_288 1315-0019 35.1 µM -1.54247374878693 0.0576311821405637 no 3181 0.0614792561629801 4553 6811474
SGTC_3116 9124943 49.47 µM -1.54328533773794 0.0575386222930229 no 3182 0.0613807797698106 4502 41905195 YPL160W CDC60
SGTC_2932 9016711 44.54 µM -1.54382117220803 0.0574775757203788 no 3183 0.0613158303736055 4498 7117328
SGTC_2235 salicylic acid 500 µM -1.54421230707609 0.0574330466687302 no 3184 0.0612684541703743 4582 338 A COX inhibitor and kinase inhibitor.
SGTC_1200 1643-0193 18.4 µM -1.54537490320025 0.0573008502261272 no 3185 0.0611278035810226 4536 5403974
SGTC_2881 9058953 51.95 µM -1.55581797822798 0.0561240988106853 no 3186 0.0598756909003026 4489 17122249
SGTC_2431 5490079 200 µM -1.56388035045137 0.0552287131191229 no 3187 0.0589228349357537 4556 5722345
SGTC_3140 9094243 49.47 µM -1.56716136416392 0.0548675783263365 no 3188 0.0585384893723674 4490 19291112
SGTC_1726 st035556 14.5795 µM -1.5760335699998 0.0539003750585349 no 3189 0.0575090334427771 4565 5919439
SGTC_318 1488-0629 67.2 µM -1.58235083333455 0.0532199638855308 no 3190 0.0567847510782535 4570 3662576
SGTC_1880 MG-132 525 µM -1.58856226917322 0.052557607484351 no 3191 0.0560796261260051 4507 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1818 st052136 56.3 µM -1.58860051742176 0.0525535492446999 no 3192 0.0560753056576368 4182 674169
SGTC_2907 7721985 69.9 µM -1.5905815878366 0.0523436923088542 no 3193 0.0558518854247909 4534 3267881
SGTC_3135 9127742 49.47 µM -1.59211393233459 0.0521818262144126 no 3194 0.0556795535774344 4583 3643468
SGTC_2289 7946404 165.07 µM -1.59423891791729 0.051958015895534 no 3195 0.0554412664195427 4518 1246120 YPR165W RHO1
SGTC_3146 9095609 49.47 µM -1.59478623788366 0.0519004940942771 no 3196 0.055380022787059 4572 17173999
SGTC_763 3453-1109 128 µM -1.60228592987035 0.0511173841472424 no 3197 0.0545461977970148 4571 1560353
SGTC_2836 9010338 19.48 µM -1.60579766928497 0.0507539387315384 no 3198 0.0541591864623717 4508 2994051
SGTC_1949 st076024 69.1 µM -1.60916456781553 0.0504074186441972 no 3199 0.053790180897834 4516 2921930
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.60989005369755 0.0503329993095746 no 3200 0.0537109303732471 4572 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1123 mangostin 811.285 nM -1.61084436214617 0.0502352410420266 no 3201 0.0536068246246808 4549 5281650 An antioxidant.
SGTC_538 2922-0838 53.3 µM -1.61107658440058 0.0502114753685978 no 3202 0.0535815156375965 4571 777039
SGTC_1495 4469-0029 237 µM -1.64087573877367 0.0472354422275354 no 3203 0.0504116060706427 4564 793680
SGTC_1511 0906-3109 28.5 µM -1.64835937379507 0.0465107084106147 no 3204 0.0496394737693749 4564 2882180
SGTC_2116 5511452 16.8835 µM -1.65035059834493 0.0463193840547958 no 3205 0.0494356244896028 4574 870744
SGTC_2636 apigenin dimethyl ether 100 µM -1.65332777862698 0.0460345045837377 no 3206 0.0491320862280244 4539 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3150 9097574 49.47 µM -1.65938557857534 0.0454591938372002 no 3207 0.0485190602107068 4594 17217476
SGTC_1650 st011916 45.8 µM -1.66078174219315 0.0453274231088855 no 3208 0.0483786446648609 4543 242528
SGTC_692 k241-0027 77.8 µM -1.66497197086749 0.0449337908894798 no 3209 0.0479591739869289 4597 3600480
SGTC_1314 1222-0010 41.1 µM -1.66731578050702 0.0447148151409397 no 3210 0.047725815205973 4574 3526027
SGTC_1028 k015-0029 4.8 µM -1.66974542299295 0.044488728268362 no 3211 0.0474848713071356 4560 4588309
SGTC_1447 4239-0816 81.9 µM -1.66990603865599 0.0444738149230044 no 3212 0.0474689777024369 4597 1341554
SGTC_1125 tnp00248 1.32998 µM -1.67491610856038 0.0440106431593216 no 3213 0.0469753462981271 4597 24207736
SGTC_2869 9037858 32.47 µM -1.67665453752 0.0438508405565435 no 3214 0.0468050277395332 4540 27187042
SGTC_1749 st037932 54.2 µM -1.68256046300778 0.0433114398789802 no 3215 0.0462301054506957 4557 594497
SGTC_762 1165-0429 115 µM -1.68713585023153 0.0428972537231732 no 3216 0.0457886164843733 4584 5967793
SGTC_996 3970-0799 1.8 µM -1.68756060543065 0.0428589657473884 no 3217 0.045747803410808 4553 6615648 YGL040C HEM2
SGTC_769 0302-0231 76 µM -1.69637288244056 0.0420708276484168 no 3218 0.0449076429438492 4508 571869 YER009W NTF2
SGTC_2285 7945142 200 µM -1.7008490426342 0.0416750118874885 no 3219 0.0444856686918665 4596 2970608
SGTC_2017 5132927 60.65 µM -1.70490534108147 0.0413189338280772 no 3220 0.0441060400456185 4563 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1920 st075728 45.7 µM -1.70976375422668 0.040895692929723 no 3221 0.0436547840159793 4566 3400306
SGTC_1359 1582-0056 520 nM -1.70976944333156 0.0408951993924687 no 3222 0.0436542577963057 4635 3661189
SGTC_1378 2093-0007 380 nM -1.71698410715203 0.0402731954416922 no 3223 0.0429910379333979 4599 3618014
SGTC_2281 7943571 200 µM -1.71877908283786 0.0401196432723956 no 3224 0.0428273028303127 4664 1244024
SGTC_45 0kpi-0036 14.9 µM -1.7193526595084 0.0400706767443906 no 3225 0.0427750883751527 4570 2795021
SGTC_1126 isoteolin 1.0172 µM -1.72055217850089 0.039968430168702 no 3226 0.0426660587824345 4536 133323
SGTC_2653 dihydrofissinolide 100 µM -1.73282504537111 0.038934431190664 no 3227 0.0415633849345327 4680 6857746
SGTC_2695 st077686 51.995 µM -1.73370853653552 0.038860844697977 no 3228 0.0414849055526815 4561 2876092
SGTC_295 k015-0027 31 µM -1.73606876323108 0.0386648154149401 no 3229 0.0412758383863385 4647 3887424
SGTC_2089 5281248 129.67 µM -1.73999827431016 0.0383402366095735 no 3230 0.0409296604878222 4593 2737878
SGTC_2095 5432005 200 µM -1.74106422102216 0.038252573148393 no 3231 0.0408361610273845 4622 783734
SGTC_1467 k284-1082 293 µM -1.74124612214138 0.0382376299374831 no 3232 0.0408202229023134 4576 3334705
SGTC_716 1683-5115 658 µM -1.74523735512641 0.0379109457547136 no 3233 0.0404717806818907 4602 723597
SGTC_2184 6075246 200 µM -1.75600133705308 0.0370412491891003 no 3234 0.0395440901306028 4593 2267320
SGTC_3097 9117246 49.47 µM -1.75857581386746 0.0368356742332167 no 3235 0.0393247920093657 4622 16423892
SGTC_2337 9009472 200 µM -1.75923733435619 0.0367830019839683 no 3236 0.0392686027124199 4569 5742383
SGTC_3174 9107204 49.47 µM -1.76743327198185 0.0361355114206818 no 3237 0.0385778474557273 4609 3938802
SGTC_2115 tiliquinol 12.7705 µM -1.76824658741945 0.0360717705627796 no 3238 0.0385098444746706 4586 71208 A bioactive hydroxyquinoline.
SGTC_1295 1013-0063 9.78 µM -1.77119215907396 0.0358416914989047 no 3239 0.0382643763513415 4622 6826038
SGTC_2415 st077333 57.7 µM -1.77121557203454 0.0358398675368182 no 3240 0.0382624303636865 4598 2766255
SGTC_2206 7254556 146.969 µM -1.7718731342123 0.0357886719005473 no 3241 0.0382078094887623 4628 4398905
SGTC_3153 9100258 49.47 µM -1.77402389141775 0.03562163938459 no 3242 0.0380295992601419 4528 25236848
SGTC_2451 5856223 45.7 µM -1.77716802156334 0.0353786097229915 no 3243 0.0377702995951038 4601 2179896
SGTC_1503 4585-0012 61.3 µM -1.78539890168967 0.0347488266525512 no 3244 0.0370983183409742 4640 2922052
SGTC_1884 5633444 25 µM -1.78583229255887 0.03471592266143 no 3245 0.0370632082010803 4562 5724239
SGTC_634 1611-4317 11.2 µM -1.78820055504302 0.0345365705727861 no 3246 0.0368718283951821 4640 2843522
SGTC_3118 9124250 49.47 µM -1.78902055908697 0.0344746481140001 no 3247 0.0368057523064301 4602 1504786
SGTC_51 1013-0126 23.419 µM -1.80801258212326 0.0330658050348618 no 3248 0.0353022711742656 4616 1627850
SGTC_3122 9126309 49.47 µM -1.81957612463851 0.0322314903333243 no 3249 0.0344117901552123 4700 17591206
SGTC_1637 st007924 17.4 µM -1.81966097235284 0.0322254333510892 no 3250 0.03440532508618 4560 683336
SGTC_970 1315-0089 19.5 µM -1.81986664711148 0.0322107548466266 no 3251 0.0343896576036386 4611 6811083 YLR033W RSC58
SGTC_1741 st038134 10.228 µM -1.84201867119847 0.0306618225614024 no 3252 0.0327362094051736 4636 1272587
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.85733380600573 0.0296274188695353 no 3253 0.0316318388066475 4630 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_294 k038-0071 157 µM -1.86173849062199 0.0293353405896026 no 3254 0.0313199801538342 4672 24152826
SGTC_287 k060-0039 29.6 µM -1.86254785567172 0.0292819318349898 no 3255 0.031262953259525 4678 5861974
SGTC_768 0384-0033 77.3 µM -1.87274294902975 0.0286160618341011 no 3256 0.0305519447429877 4617 3965305 YMR134W ERG29
SGTC_470 aa-861 153 µM -1.87704584980059 0.0283388313230784 no 3257 0.0302559050406602 4604 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2412 st077135 33.4 µM -1.88991326853544 0.0275231052370825 no 3258 0.0293847803434173 4638 13258915
SGTC_343 4130-2827 29.8 µM -1.91625261964041 0.0259142919834815 no 3259 0.0276664742732562 4657 1118244
SGTC_572 0960-0087 17.7 µM -1.91839125412227 0.0257871905284179 no 3260 0.0275307095945054 4639 6796365
SGTC_2820 7989630 71.43 µM -1.92761182630161 0.0252451599385245 no 3261 0.026951713382447 4687 2984098
SGTC_2381 9035592 200 µM -1.93004016009237 0.025104009271982 no 3262 0.0268009309583795 4675 4749657
SGTC_1707 st032323 6.317 µM -1.9310706743646 0.0250443092705233 no 3263 0.0267371565027616 4487 3132057 YMR211W DML1
SGTC_2571 chrysanthemic acid 100 µM -1.93164921311399 0.0250108454189759 no 3264 0.0267014086067121 4647 2743 An insecticide.
SGTC_303 1348-1668 34.2 µM -1.93897139715548 0.0245905453058366 no 3265 0.0262524105588168 4693 5380509
SGTC_548 1436-0017 110 µM -1.94638383276067 0.0241711178267741 no 3266 0.025804325079839 4694 9677137
SGTC_1483 3453-0561 55.9 µM -1.94825030652324 0.024066456910096 no 3267 0.0256925100229732 4702 4546991
SGTC_2671 danthron 100 µM -1.9568724189679 0.0235879085043931 no 3268 0.0251812350067124 4664 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_806 3966-4455 5.86 µM -1.96504996610519 0.0231414548624396 no 3269 0.0247042273611102 4672 714982
SGTC_3080 9117754 49.47 µM -1.96573846276429 0.0231041932470882 no 3270 0.0246644147079648 4669 9550191
SGTC_1051 3253-3903 78 µM -1.97673807005073 0.0225157097347746 no 3271 0.0240356225854748 4682 5509239
SGTC_2090 5301565 104.445 µM -1.9772677686621 0.02248769256278 no 3272 0.0240056854584623 4689 2056344
SGTC_367 0335-0881 7.1 µM -1.97871579186324 0.0224112527450488 no 3273 0.0239240069775577 4607 23828853
SGTC_3293 9120939 62.045 µM -1.99439942159282 0.0215972776769062 no 3274 0.023054210842628 4665 934087
SGTC_724 3910-0327 137 µM -1.99825320824046 0.0214011356150049 no 3275 0.0228446078091353 4690 2885483
SGTC_348 k064-0012 10.7 µM -2.01899167864821 0.0203713064280233 no 3276 0.0217440422043194 4665 5066323
SGTC_1446 4239-0190 62 µM -2.02720984256141 0.0199749908874038 no 3277 0.0213204785019272 4689 1340085
SGTC_1376 2910-0861 41.3 µM -2.03165032840498 0.0197635868341309 no 3278 0.0210945338951004 4648 1112859
SGTC_266 formosanin C 406 nM -2.04127502049609 0.0193118837526423 no 3279 0.0206117492571694 4559 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2118 5526350 200 µM -2.0493246509709 0.0189408668283728 no 3280 0.0202151898663089 4692 743594
SGTC_1522 st012842 45.6 µM -2.06874203307566 0.0180707717980585 no 3281 0.0192851502943287 4551 3491067 YOR116C RPO31
SGTC_1298 1079-1278 263 µM -2.07587342928472 0.0177598832566346 no 3282 0.0189528293846551 4685 2840950
SGTC_2322 7413319 38.22 µM -2.08123497110905 0.0175291658262276 no 3283 0.0187062020258308 4627 1840400
SGTC_60 0986-0278 202 µM -2.08559500405474 0.0173434362620702 no 3284 0.018507662143151 4668 3110598
SGTC_333 3486-0131 40.1 µM -2.09392909921326 0.0169930929374049 no 3285 0.0181331483155522 4708 6744690
SGTC_3091 9116372 49.47 µM -2.09527823873526 0.0169369514947305 no 3286 0.018073132883156 4712 17169793
SGTC_1079 idarubicin 2.36 µM -2.09899866238626 0.0167829553210478 no 3287 0.0179085093233704 4726 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2646 retinol 96.75 µM -2.12003602222478 0.0159345256306087 no 3288 0.0170015037886464 4723 445354 A vitamin A analog and teratogen.
SGTC_2992 9074591 71.4286 µM -2.1378586103658 0.0152447800080785 no 3289 0.0162641101873186 4665 17741321
SGTC_981 1488-1094 54.9 µM -2.14756191137766 0.0148801538096547 no 3290 0.0158742869723625 4687 3449522
SGTC_1367 1812-0510 76.9 µM -2.15254179839701 0.0146959512890688 no 3291 0.0156773534535766 4719 1142582 YDR527W RBA50
SGTC_1170 0310-0127 64.8 µM -2.15808623722873 0.0144931775080945 no 3292 0.0154605637945037 4718 774975
SGTC_2228 7354201 200 µM -2.17755844456407 0.0137999986584494 no 3293 0.014719463087232 4761 753451
SGTC_2406 ethylparaben 405.7 µM -2.19768484731729 0.0131137718589598 no 3294 0.0139857860497424 4679 8434 A possible steroid mimic.
SGTC_1473 k844-0725 134 µM -2.20628630937677 0.0128296150963765 no 3295 0.0136819796783184 4752 54682906
SGTC_2215 7188065 200 µM -2.21993848665198 0.0123895384476449 no 3296 0.0132114717597943 4746 940217
SGTC_1064 honokiol 6.76 µM -2.22581038195458 0.0122043167976348 no 3297 0.0130134425599773 4723 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2821 7996764 71.43 µM -2.23428114061354 0.0119413471101568 no 3298 0.0127322902220431 4691 2987135
SGTC_2085 5307070 144.047 µM -2.24371672619697 0.0116542243938872 no 3299 0.0124253166182657 4690 2840351
SGTC_255 tunicamycin 200.472 nM -2.24959242650965 0.0114784724268099 no 3300 0.0122374148287083 4693 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1209 2323-2347 50.3 µM -2.25342939825845 0.0113649487970161 no 3301 0.0121160438255809 4730 5412760
SGTC_771 0250-0039 27.3 µM -2.26500057949106 0.0110284822351206 no 3302 0.0117563219774177 4699 3005115
SGTC_2034 5197015 53.07 µM -2.28360389040043 0.0105056923523385 no 3303 0.0111974104708218 4731 780676
SGTC_1715 st032160 10.2275 µM -2.32008444930798 0.00954290646532683 no 3304 0.0101681546991813 4673 5289825
SGTC_3110 9122132 49.47 µM -2.32174920916423 0.00950087347074435 no 3305 0.010123221780987 4734 918317
SGTC_334 1502-1024 68.5 µM -2.3277411832431 0.00935092099460556 no 3306 0.00996292545474025 4740 3296216
SGTC_1554 st069299 38.7 µM -2.35555870167434 0.00868157051532572 no 3307 0.00924743730043579 4727 24207999
SGTC_339 3091-4833 71.4 µM -2.36786016205737 0.00839922376070146 no 3308 0.00894564836791481 4585 3240077
SGTC_2436 5633522 8.09 µM -2.37444166223409 0.00825149890413449 no 3309 0.00878775664911959 4720 5724242
SGTC_2048 5246248 200 µM -2.38173637162398 0.00809043665389583 no 3310 0.00861561413132617 4760 677046
SGTC_29 0299-0004 12.984 µM -2.40443044806439 0.00760690025050315 no 3311 0.00809884407372615 4704 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2229 7354935 190 µM -2.41442362123675 0.00740217483775499 no 3312 0.00788006343023744 4751 318112
SGTC_1916 st067606 49.2 µM -2.41568803208358 0.00737662062830564 no 3313 0.00785275553059 4679 19590279
SGTC_774 k060-0086 136 µM -2.42315409616727 0.00722730781518491 no 3314 0.0076931992303157 4751 5911235
SGTC_547 1120-0019 610 nM -2.42735204254202 0.00714452963586883 no 3315 0.00760474461912643 4744 3676939
SGTC_1787 fluconazole 80 µM -2.43117379813352 0.00706989794226253 no 3316 0.0075249967153405 4454 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3329 9141233 27.5565 µM -2.43885155271476 0.00692204228054152 no 3317 0.00736700973601799 4728 4909101 YNL103W MET4
SGTC_2063 5246145 200 µM -2.44735411117104 0.00676149487905162 no 3318 0.00719546859931004 4745 711240
SGTC_2423 st077119 87.2 µM -2.4656825012407 0.0064265598238989 no 3319 0.00683762452503445 4686 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1082 camptothecin 424.86 nM -2.4801186152458 0.00617317490453986 no 3320 0.00656693417141772 4671 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2795 7780010 54.55 µM -2.48365337587936 0.00611249729229898 no 3321 0.00650211600122475 4732 953673
SGTC_3083 9117465 49.47 µM -2.48958523559195 0.0060118580121353 no 3322 0.00639461240137518 4728 16420915
SGTC_749 1000-0129 128 µM -2.50634805671196 0.00573535720921405 no 3323 0.00609927370679972 4773 708470
SGTC_2896 9052656 71.43 µM -2.52704862641167 0.00540951766945273 no 3324 0.00575127877175916 4438 6469436
SGTC_2777 climbazole 1.536 µM -2.5526581152959 0.00502924636010459 no 3325 0.00534521871947889 4595 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2291 7917025 104.35 µM -2.55294411813183 0.00502513748468851 no 3326 0.00534083162814374 4718 2964612
SGTC_2300 7976697 71.57 µM -2.56275476170923 0.00488599029610347 no 3327 0.00519226850042831 4701 2236109
SGTC_984 1492-0255 2.91 µM -2.58852293377254 0.00453672899307872 no 3328 0.00481942641779052 4749 1585198
SGTC_2832 7992762 51.95 µM -2.5931967104537 0.00447582452794098 no 3329 0.00475441830382872 4705 2985177
SGTC_746 1095-0025 46.6 µM -2.59941331766243 0.00439594720342826 no 3330 0.00466916299226138 4774 6749286
SGTC_1174 0739-0097 51.1 µM -2.62386688668134 0.00409396035803777 no 3331 0.00434688776335408 4779 728447
SGTC_2420 aureobasidin a 50 nM -2.63573056483603 0.00395425177730806 no 3332 0.00419781832210688 4768 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_345 1362-0200 395 µM -2.78188929865171 0.00255142580599026 no 3333 0.00270217354353204 4766 1419823
SGTC_2585 alliin 100 µM -2.83128591488616 0.00219070768618959 no 3334 0.00231806289963398 4763 87310 A garlic compound which reacts with lipids.
SGTC_1040 k898-0338 155 µM -2.83768371488304 0.00214753596831209 no 3335 0.00227210936172648 4775 20969351
SGTC_47 0149-0135 24.25 µM -2.89797295756909 0.00177702952739314 no 3336 0.00187791486209647 4781 5239155
SGTC_454 lyso-paf C-16 6.67 µM -2.90445936888255 0.00174084781779766 no 3337 0.00183943975139854 4776 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2989 9073649 71.4286 µM -2.95294413319247 0.00149092997321348 no 3338 0.00157379460892263 4772 21367202
SGTC_1046 2001-0062 216 µM -2.96026531645481 0.00145617622206339 no 3339 0.00153687103346595 4781 739778
SGTC_2123 5259487 200 µM -2.99759072782146 0.00129021486731461 no 3340 0.00136061423106945 4786 2173474
SGTC_2043 5101342 149 µM -3.03300552318057 0.00114892492473539 no 3341 0.00121065584219689 4796 678451
SGTC_1124 fisetin 1.16336 µM -3.10020443186369 0.000919076158669192 yes 3342 0.000966935582888969 4784 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2424 5537928 59.2 µM -3.11974492690853 0.000860651123765269 yes 3343 0.000905038538242806 4788 5382802
SGTC_1509 1326-1131 80 µM -3.13136779550086 0.000827539643850177 yes 3344 0.000869970525094974 4771 768313
SGTC_1514 1189-1591 158 µM -3.15004809117188 0.000776770166467632 yes 3345 0.000816217943844753 4791 767698 YMR146C TIF34
SGTC_828 2074-0507 139 µM -3.18474565263905 0.000690005211010195 yes 3346 0.00072440643032532 4799 X828
SGTC_453 enantio-paf c16 10 µM -3.21303959781477 0.000625967625462097 yes 3347 0.000656690903258297 4447 13871343 A lipid and platelet activating factor
SGTC_151 3013-0144 2.285 µM -3.32732602526047 0.00041922618309206 yes 3348 0.000438418606272802 4682 906558 YHR107C CDC12
SGTC_2582 agaric acid 100 µM -3.35165474958099 0.00038433888514854 yes 3349 0.000401650646865352 4646 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3016 9080866 49.47 µM -3.39145990818144 0.000333017295119514 yes 3350 0.000347606667688892 4803 17066299
SGTC_1718 roemerine 11.9335 µM -3.40115379623261 0.000321522689520559 yes 3351 0.000335510321171184 4621 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1215 3852-0577 11.2 µM -3.50930237690284 0.000216008775271964 yes 3352 0.000224641901899401 4810 2884876
SGTC_1395 3486-0190 4.35 µM -3.60235126550647 0.000152089642380126 yes 3353 0.000157675919592835 4803 6748079
SGTC_2566 crystal violet carbinol 226 nM -3.87623094972973 5.1690199817804e-05 yes 3354 5.30434976912651e-05 4774 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2104 5389443 200 µM -4.20908262492049 1.26766801608823e-05 yes 3355 1.28204809332752e-05 4807 2244536
SGTC_3012 9080433 71.4286 µM -4.42274422076576 4.86940944003331e-06 yes 3356 4.87275453698722e-06 4809 17688859