SGTCid condition conc unit SPT3|YDR392W.score SPT3|YDR392W.strain.pval SPT3|YDR392W.strain.significant SPT3|YDR392W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2932 9016711 44.54 µM 44.4942646503663 1.69434237667992e-253 yes 1 0 1 7117328
SGTC_2858 9025781 8.96 µM 26.8397544199999 1.01493623795065e-93 yes 2 5.55453683527063e-159 1 4894980 YPL153C RAD53
SGTC_1287 0971-0001 34.6 µM 21.7891596957028 1.64109661284377e-62 yes 3 1.46997913633139e-105 1 4665869
SGTC_1687 st020778 55.3625 µM 19.8921482858829 1.87462596231247e-52 yes 4 2.37959767576838e-88 9 4259299
SGTC_505 gw-5074 63.9 µM 18.6663505315594 1.94554386506741e-46 yes 5 4.64971292893009e-78 3 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_664 1222-0054 14.9 µM 18.6599157746873 2.08748053997232e-46 yes 6 5.24482060791677e-78 3 6813991
SGTC_955 1216-0110 33 µM 17.4912708514477 5.01813529046089e-41 yes 7 8.34957515446282e-69 5 3619719
SGTC_2976 9009005 19.48 µM 17.3172177086745 2.96826260972507e-40 yes 8 1.74410165942334e-67 3 2993148
SGTC_1754 st042065 16.137 µM 16.0839577292133 5.29228077590017e-35 yes 9 1.65284404848678e-58 7 1126236 YIL048W NEO1
SGTC_2752 diclazuril 33.15 µM 14.6195484897251 2.89571316598843e-29 yes 10 1.0539679782974e-48 9 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_439 amiodarone 34.4 µM 12.8926645918153 3.43247609096096e-23 yes 11 2.47516772652301e-38 8 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1801 st050089 28.441 µM 12.2305211705055 4.63418545270765e-21 yes 12 1.06781989657423e-34 5 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1694 st024011 44.9 µM 12.0195440669512 2.09736816798618e-20 yes 13 1.40257488633544e-33 7 2787533
SGTC_1803 st050068 52.4 µM 11.7119457496114 1.81002498451832e-19 yes 14 5.53547056853271e-32 16 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1800 st050079 29.0735 µM 10.3866410692761 1.04653194264409e-15 yes 15 1.42610677075142e-25 2 3645560
SGTC_3059 1327-0034 3 µM 10.2623625864355 2.23883505544239e-15 yes 16 5.2063709258685e-25 9 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_227 fluconazole 33.516 µM 10.2331836046951 2.67304486395986e-15 yes 17 7.04063367168067e-25 16 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_43 0570-0105 72.5 µM 10.0762396907657 6.87754014893807e-15 yes 18 3.51838701418991e-24 10 1114046 YDL195W SEC31
SGTC_628 1636-0253 16 µM 9.99641664162321 1.10617071182281e-14 yes 19 7.90057711037263e-24 3 4456143
SGTC_1877 wortmannin 25 µM 9.8626245457865 2.43325985292751e-14 yes 20 3.02241454863314e-23 16 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3063 1327-0034 4 µM 9.47622242199894 2.23830016176552e-13 yes 21 1.31827647912608e-21 10 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1941 st076221 61.8 µM 9.2545866908354 7.68989101205107e-13 yes 22 1.07530410658931e-20 15 2828568
SGTC_1226 3909-7979 35.4 µM 9.2263584984453 8.98068093635677e-13 yes 23 1.39994437523053e-20 7 6615510
SGTC_1304 1165-0502 251 µM 9.02055951062098 2.74550561394376e-12 yes 24 9.3565539264556e-20 12 767425
SGTC_1991 st073000 8.92 µM 8.95656199610493 3.86717563239098e-12 yes 25 1.67479569004315e-19 13 4301969 YIL048W NEO1
SGTC_513 4245-1575 41.7 µM 8.75887078093044 1.09781147886022e-11 yes 26 9.86080207470369e-19 23 719745
SGTC_1760 st045453 10.4495 µM 8.53917373025846 3.4096915427471e-11 yes 27 6.75924989118076e-18 45 3323419 YIL048W NEO1
SGTC_3060 1327-0027 12.5 µM 8.24851188790979 1.46380421740704e-10 yes 28 8.0189533670648e-17 12 16000455 YPR107C YTH1
SGTC_683 panaxydol 45 µM 8.24549697612237 1.48571899588813e-10 yes 29 8.22375931776627e-17 4 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_7 0192-1582 4.227 µM 7.91636160142786 7.29360488909719e-10 yes 30 1.22280841718905e-15 14 252616
SGTC_2699 st077704 54.6 µM 7.9099105774002 7.52000198743597e-10 yes 31 1.28786921612645e-15 11 645852
SGTC_598 3937-0236 20.2 µM 7.7898869631272 1.32233154530621e-09 yes 32 3.35345847184861e-15 5 1379313
SGTC_634 1611-4317 11.2 µM 7.66276811110163 2.38270382722216e-09 yes 33 9.09838637996976e-15 3 2843522
SGTC_252 miconazole 1.30953 nM 7.58446203782002 3.40889964492844e-09 yes 34 1.66934701541717e-14 7 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1818 st052136 56.3 µM 7.35684674447146 9.46555788036425e-09 yes 35 9.4152663641372e-14 5 674169
SGTC_2322 7413319 38.22 µM 7.30368485953047 1.19645600229164e-08 yes 36 1.39995870558666e-13 43 1840400
SGTC_196 k015-0023 18.111 µM 7.30003365381549 1.21579255908523e-08 yes 37 1.43847879391488e-13 2 5211998
SGTC_562 3772-2733 112 µM 7.18131521436343 2.03921174460819e-08 yes 38 3.45219788131867e-13 26 2876874 YIL048W NEO1
SGTC_221 trifluoperazine 10.304 µM 7.02070467859243 4.05318619152453e-08 yes 39 1.10376006826878e-12 101 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1934 st074720 32.6 µM 6.89217716368039 6.94968415211253e-08 yes 40 2.74724417569428e-12 11 17250992
SGTC_90 0870-0863 4.608 µM 6.87736311449077 7.39084760184092e-08 yes 41 3.04852803975837e-12 10 1738164
SGTC_824 1304-0008 100 µM 6.86288080285389 7.84824831708887e-08 yes 42 3.37427680709957e-12 5 768245
SGTC_2651 TUB2.036 5 µM 6.86062180128856 7.92201942002463e-08 yes 43 3.42807284643084e-12 48 15992207 YFL037W TUB2
SGTC_2765 myclobutanil 7.74 µM 6.78823714218996 1.06749861348051e-07 yes 44 5.67559812353716e-12 7 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_919 tnp00227 403.569 nM 6.7748454832515 1.12769187515849e-07 yes 45 6.22696448493922e-12 4 1269246 A methoxyflavone. YNL221C POP1
SGTC_2132 5317594 122.667 µM 6.70160765063502 1.51949146575591e-07 yes 46 1.03069454295789e-11 9 794577
SGTC_1277 0873-0036 22 µM 6.60734884215593 2.22044838054241e-07 yes 47 1.95631670944029e-11 5 5965735
SGTC_2701 st077767 14.721 µM 6.55760111704959 2.70713309946998e-07 yes 48 2.7340116459142e-11 12 5721188
SGTC_176 1486-1328 72.834 µM 6.43262829024859 4.42639853979195e-07 yes 49 6.27080482149299e-11 17 22310231
SGTC_109 0132-0036 33.701 µM 6.22635921591839 9.77551166560637e-07 yes 50 2.3869940444701e-10 8 67274 A color developer.
SGTC_2778 tioconazole 65.09 nM 6.02586836034033 2.06359464532591e-06 yes 51 8.41020250434119e-10 30 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_8 0354-0001 70 µM 5.94700809508681 2.75149278890635e-06 yes 52 1.36543955392657e-09 26 4993152
SGTC_626 0214-0009 33 µM 5.89379669908862 3.33440719838249e-06 yes 53 1.88710740165815e-09 5 3437874
SGTC_804 1595-0054 20.9 µM 5.8659852211334 3.68434531632431e-06 yes 54 2.23236782781199e-09 13 761523 Stimulates phospholipase C.
SGTC_2014 4013930 200 µM 5.80209820567279 4.62604030465467e-06 yes 55 3.27450920212181e-09 3 64556
SGTC_265 mycophenolic acid 32.932 µM 5.7852451436555 4.91043223513177e-06 yes 56 3.62033296887081e-09 1 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2018 5133068 143 µM 5.75684479125913 5.4278371115837e-06 yes 57 4.28503193644973e-09 4 785362
SGTC_266 formosanin C 406 nM 5.70993685520243 6.39818137405611e-06 yes 58 5.65090488938365e-09 32 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_422 cantharidin 155 µM 5.69176789906829 6.81678955210278e-06 yes 59 6.28653451468447e-09 23 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_70 0141-0289 43.283 µM 5.6809983051927 7.07711734398047e-06 yes 60 6.69554022571482e-09 92 352408
SGTC_156 3474-0145 5.642 µM 5.66832921779276 7.39550120909957e-06 yes 61 7.20983496469842e-09 24 2265471
SGTC_3174 9107204 49.47 µM 5.65304144064091 7.79789149699679e-06 yes 62 7.88166408263337e-09 9 3938802
SGTC_470 aa-861 153 µM 5.60679604903077 9.1460889339436e-06 yes 63 1.0305314471987e-08 27 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2816 7982706 58.44 µM 5.56396753383864 1.05904258439988e-05 yes 64 1.31854514666854e-08 20 2981853
SGTC_1861 st057647 17.4 µM 5.53858639397652 1.15462354600885e-05 yes 65 1.52461409154549e-08 4 688668
SGTC_275 trichlorophene 5.69 µM 5.52150372225114 1.22351647563413e-05 yes 66 1.68055346340333e-08 137 62616
SGTC_108 0509-0257 621.132 µM 5.50192380611293 1.30728901380506e-05 yes 67 1.87834655629452e-08 17 536624
SGTC_2685 mycophenolic acid 18.85 µM 5.48283580451881 1.39418799768058e-05 yes 68 2.09280734778424e-08 1 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1072 oxiconazole 14.9 nM 5.45719593712964 1.51958748424284e-05 yes 69 2.41856245853063e-08 27 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3025 9087895 49.47 µM 5.3806774221505 1.96068093827221e-05 yes 70 3.71030309709742e-08 22 17173641
SGTC_488 nitrendipine 139 µM 5.284619129076 2.68748278477735e-05 yes 71 6.29832777660469e-08 24 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_293 4049-0273 38.5 µM 5.27816094180388 2.74455729077085e-05 yes 72 6.52434184870659e-08 8 1380311
SGTC_639 0833-0042 114 µM 5.22869358649127 3.22139912078999e-05 yes 73 8.53560113850639e-08 18 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_453 enantio-paf c16 10 µM 5.19397670047189 3.60178955798775e-05 yes 74 1.0292445723921e-07 81 13871343 A lipid and platelet activating factor
SGTC_2688 kanamycin b 96.69 µM 5.17267116622221 3.85586942728829e-05 yes 75 1.15385467171301e-07 230 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2814 7977482 42.97 µM 5.1314718935807 4.39600213638975e-05 yes 76 1.43742579103481e-07 17 6456762
SGTC_2953 9074162 66.49 µM 5.08319443682085 5.1198153621503e-05 yes 77 1.85569714611334e-07 8 16451992
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 5.02340561858313 6.17242940805671e-05 yes 78 2.53815882135973e-07 17 688788
SGTC_829 1635-0120 117 µM 5.0161552805172 6.31312809645918e-05 yes 79 2.63578643062984e-07 20 285054
SGTC_457 grayanotoxin iii 135 µM 4.93758913922412 8.04457530070852e-05 yes 80 3.95471285780523e-07 29 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_295 k015-0027 31 µM 4.81640976897248 0.000116129614899205 yes 81 7.30821067384983e-07 5 3887424
SGTC_1997 st073024 93.8 µM 4.79147943707612 0.000125114424818748 yes 82 8.27779952346947e-07 3 686268
SGTC_205 1486-1330 71.903 µM 4.7507447309606 0.000141210873612196 yes 83 1.01334423034495e-06 10 4118834
SGTC_1569 carminic acid 40.6 µM 4.74541817067812 0.000143453678625661 yes 84 1.0403800986844e-06 6 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2023 5144124 124 µM 4.69090543918107 0.000168406438825562 yes 85 1.35999333156281e-06 13 2830192
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 4.67134502049015 0.000178310177659298 yes 86 1.49616913902636e-06 30 2374 Ca(2+)-ATPase inhibitor.
SGTC_1810 st050138 53 µM 4.66781739757582 0.00018015324310038 yes 87 1.52208130862649e-06 2 3444541
SGTC_1044 1222-0021 1.78 µM 4.66747659750652 0.000180332240268407 yes 88 1.52460733786243e-06 27 4306703
SGTC_528 3492-0019 172 µM 4.66498225994249 0.000181647403803196 yes 89 1.5432183239811e-06 172 2869262
SGTC_447 ml7 120 µM 4.66091473710355 0.000183811297409203 yes 90 1.57403562178646e-06 19 4216 Selective myosin light chain kinase inhibitor.
SGTC_2004 4023728 41.89 µM 4.58259728431613 0.000230475976039328 yes 91 2.29617969868663e-06 17 360084 YDR527W RBA50
SGTC_800 3448-7362 155 µM 4.48448839433128 0.00030453745202175 yes 92 3.65445419060564e-06 119 15991913
SGTC_847 0342-0274 5.54 µM 4.40837624855883 0.000376653241150564 yes 93 5.20742508450325e-06 14 18097
SGTC_3098 9119039 49.47 µM 4.29775578206641 0.000510072462743714 yes 94 8.62680540156862e-06 30 17161528
SGTC_134 0269-0018 6.916 µM 4.26434098452675 0.000558263306862708 yes 95 1.00246533867982e-05 121 4378915
SGTC_2311 7694451 200 µM 4.24852705625938 0.000582508020612782 yes 96 1.07590330744638e-05 13 2163142
SGTC_1581 himbacine 57.9 µM 4.23892207237768 0.000597704869847607 yes 97 1.12297799055814e-05 44 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3265 9137266 49.47 µM 4.19707424177376 0.000668286491144484 yes 98 1.35192658545448e-05 6 17224265
SGTC_1909 st060837 51.5 µM 4.15264710367306 0.000751574606332767 yes 99 1.64325676996009e-05 45 678937
SGTC_146 3448-8650 53.125 µM 4.14184693460067 0.000773217660192604 yes 100 1.72260122246789e-05 126 2891488 YIL048W NEO1
SGTC_3281 9140613 49.47 µM 4.13689216503246 0.000783337607555473 yes 101 1.76020723564253e-05 15 16013766
SGTC_2812 7970281 58.44 µM 4.12148390274205 0.000815592930762183 yes 102 1.88219889372108e-05 25 2233435
SGTC_1281 0884-0031 11.8 µM 4.10641318008732 0.000848319949735574 yes 103 2.00925201711206e-05 20 1548255
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 4.1062234704091 0.000848739507996416 yes 104 2.01090206032405e-05 67 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3189 9110682 49.47 µM 4.05735975706703 0.000963388341272492 yes 105 2.48153006355324e-05 34 17122418
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 4.04618981741646 0.000991518819911919 yes 106 2.60290128851789e-05 6 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_15 0266-0086 27.098 µM 3.99318690540293 0.00113556393844429 no 107 3.25955705907341e-05 60 1712902 YIL048W NEO1
SGTC_865 0488-0499 301 µM 3.97741418250643 0.00118199150236347 no 108 3.48343769429376e-05 18 9634651
SGTC_3064 1327-0027 10 µM 3.97111457332018 0.00120101547558934 no 109 3.57685814879429e-05 9 16000455 YPR107C YTH1
SGTC_3013 9080133 71.4286 µM 3.9288538124634 0.00133605696194592 no 110 4.26758516706982e-05 20 17050193
SGTC_2563 tomatine 8.54 µM 3.9071840199917 0.00141055705321843 no 111 4.6689018387869e-05 49 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_127 0180-0333 59.125 µM 3.86318931522076 0.00157360062035535 no 112 5.59581030242734e-05 49 771601
SGTC_195 4234-0266 16.654 µM 3.83910173737435 0.0016699773296638 no 113 6.17426290479561e-05 35 2303354
SGTC_12 0849-0099 9.267 µM 3.83744236573009 0.00167681055978898 no 114 6.21612000075602e-05 20 6071388
SGTC_3271 9137798 49.47 µM 3.8108900407195 0.0017896716484314 no 115 6.92336762571524e-05 8 6498326
SGTC_214 4373-3496 70 µM 3.78662375632548 0.00189881369716718 no 116 7.63540282831234e-05 65 3779166
SGTC_1364 1653-0028 37.6 µM 3.78290498944537 0.00191606397241991 no 117 7.75042973358467e-05 27 5718652
SGTC_612 0302-0167 22.4 µM 3.77294164334636 0.00196298508651685 no 118 8.0667017028792e-05 39 235821
SGTC_489 paxilline 115 µM 3.76054874053634 0.00202280319434806 no 119 8.47705176714115e-05 21 105008 A toxic potassium channel blocker.
SGTC_3046 9092212 49.47 µM 3.73454963811506 0.00215370498705251 no 120 9.40256999595283e-05 11 25236637
SGTC_2489 cantharidin 73.42 µM 3.70877699589171 0.00229100105512101 no 121 0.000104131373440131 52 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2309 7664088 163.95 µM 3.70450270546028 0.00231452249876572 no 122 0.000105902923776679 44 704922
SGTC_1634 st006576 41 µM 3.70175168186273 0.00232977683989072 no 123 0.000107058060033415 26 3915356
SGTC_2328 6201408 200 µM 3.68072595701661 0.00244940335767815 no 124 0.000116285429012229 26 2890418
SGTC_3309 9129340 25.759 µM 3.64321025744456 0.00267672847990433 no 125 0.000134629357297055 21 17158987
SGTC_3080 9117754 49.47 µM 3.59531342835146 0.00299458123408103 no 126 0.00016200063000443 27 9550191
SGTC_2810 7959871 45.46 µM 3.58070934611756 0.00309804869616728 no 127 0.000171331334288282 51 2974535
SGTC_1974 st069448 26.9 µM 3.57166747700766 0.00316371128479756 no 128 0.000177357801920465 35 6323587 YNR016C ACC1
SGTC_843 0310-0051 143 µM 3.55200639989183 0.00331083280252321 no 129 0.000191152780842676 19 2065037
SGTC_1700 st030840 7.9285 µM 3.53932520075088 0.00340895938069365 no 130 0.000200575670611217 30 5499307
SGTC_1173 0443-0020 122 µM 3.53724990488577 0.00342526445795004 no 131 0.000202158451156106 55 5331295
SGTC_2429 5902844 64.44 µM 3.51434067649452 0.00360996857635469 no 132 0.000220423517726813 47 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2742 clothiapine 36.27 µM 3.44424706706884 0.00423187760198193 no 133 0.000286326076678166 27 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 3.43022794621608 0.00436719344938958 no 134 0.000301537195143173 39 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2270 7924575 90.91 µM 3.40661783310608 0.00460384140998836 no 135 0.000328865761228488 31 1262135
SGTC_1556 plumbagin 1.48 µM 3.40097830663008 0.0046620337423675 no 136 0.000335725780338453 32 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_543 3844-1095 191 µM 3.38797335142437 0.00479873608203983 no 137 0.000352055525050528 67 4230703
SGTC_486 niguldipine 82 µM 3.38493235453677 0.00483121274982769 no 138 0.0003559789881275 31 1236 A calcium channel blocker.
SGTC_1788 fluconazole 20 µM 3.37244370697792 0.00496665066846918 no 139 0.000372521574736239 83 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_197 4544-0043 41.561 µM 3.35993942066565 0.00510563664732184 no 140 0.000389797824625199 70 896523
SGTC_585 0kpi-0023 191 µM 3.35532510205091 0.00515779320539238 no 141 0.000396358823574522 38 64601
SGTC_1915 st067105 30.6 µM 3.35011570212918 0.00521724550225387 no 142 0.000403889056309575 75 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2925 9010536 32.5 µM 3.34855940815581 0.00523512461077428 no 143 0.000406164315747706 77 2994177
SGTC_408 cantharidin 100 µM 3.34474568396429 0.00527916831827244 no 144 0.000411790252595878 43 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2202 7226349 200 µM 3.34134370241678 0.00531873473000043 no 145 0.000416869716942791 20 844334
SGTC_2435 5706476 10.6 µM 3.32407234726556 0.00552370335446156 no 146 0.000443565892820162 44 5725375
SGTC_3103 9120822 49.47 µM 3.31979730614892 0.00557550879434109 no 147 0.000450414139164797 35 17141819
SGTC_3237 9133362 49.47 µM 3.30879444859384 0.00571083263091858 no 148 0.000468493003602328 55 43845137
SGTC_629 3448-6466 76.7 µM 3.29381990244059 0.00589968558747727 no 149 0.000494179014764782 41 573744
SGTC_3144 9087057 49.47 µM 3.26914665750603 0.00622295490819854 no 150 0.000539361869509455 34 17249618
SGTC_59 0330-0160 1.33 µM 3.26617063886172 0.00626298814257045 no 151 0.000545062690388824 168 4293482
SGTC_1151 3909-8316 15.3 µM 3.26042166705285 0.00634096921852603 no 152 0.000556233456147012 43 800431
SGTC_895 0964-0006 13.7 µM 3.2503486540345 0.00647967710339307 no 153 0.00057631800726917 38 6738897
SGTC_3166 9102297 49.47 µM 3.22084909676729 0.00690145516412725 no 154 0.00063905713274362 56 25237072
SGTC_786 4544-0069 423 µM 3.21823975157883 0.00693990497603906 no 155 0.000644899789148737 67 748821 YLR208W SEC13
SGTC_1141 3253-0389 52.6 µM 3.18915792859124 0.00738140876832502 no 156 0.000713439504933148 21 5402031
SGTC_1099 5-nonyloxytryptamine 2.85 µM 3.18861794455038 0.00738983541400808 no 157 0.000714773392988387 50 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_180 1486-1293 102.781 µM 3.15028430490269 0.00801013347975031 no 158 0.000815558247092541 75 4140536
SGTC_839 0122-0028 230 µM 3.13875005199938 0.00820552419693441 no 159 0.000848350522854162 75 759448
SGTC_2666 tannic acid 100 µM 3.13592593150264 0.00825399833036909 no 160 0.000856562320312403 72 16134267 A thiamine antagonist.
SGTC_517 1365-0151 113 µM 3.13280456282436 0.00830786698718769 no 161 0.000865723446902229 60 768657
SGTC_3241 9133421 49.47 µM 3.13135685069044 0.00833295626927953 no 162 0.000870002951308534 8 17018221
SGTC_1425 4048-4433 7.33 µM 3.08396977177895 0.00919176356321581 no 163 0.00102129174056146 82 23734946
SGTC_710 3448-4187 58 µM 3.06309607162916 0.00959401513425014 no 164 0.00109529859916401 122 3946412
SGTC_256 clotrimazole 625 nM 3.05823163817873 0.0096899377920335 no 165 0.00111323699858399 76 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_445 e6 berbamine 66 µM 3.05741814294257 0.00970606077988313 no 166 0.00111626303980346 182 6610268 A calcium/calmodulin antagonist.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.05700359299028 0.00971428592352445 no 167 0.00111780798101743 65 6312947
SGTC_2452 5863136 48.41 µM 3.05684644999378 0.00971740541114506 no 168 0.00111839413214748 64 2184096
SGTC_302 1094-0063 18.9 µM 3.04095182763802 0.0100374897492718 no 169 0.00117915779292944 36 5440289
SGTC_2257 7960413 200 µM 3.03062353878748 0.0102503783054468 no 170 0.00122024662896669 110 2974689 YIL048W NEO1
SGTC_2303 7774051 200 µM 3.02687896375616 0.0103285291067581 no 171 0.00123546438010022 52 2953184
SGTC_2223 6903751 107.57 µM 3.02413598651346 0.0103861053269352 no 172 0.00124672166511905 34 5598863
SGTC_315 k915-0449 187 µM 2.99825231750979 0.0109433344407443 no 173 0.00135766383199089 112 20970215 YNL149C PGA2
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.99336793259919 0.0110513551929711 no 174 0.00137958447693249 44 756377
SGTC_143 4032-1194 15.74 µM 2.9916101343152 0.011090456148876 no 175 0.00138755208645344 141 1806963
SGTC_1568 digitonin 820 nM 2.96823769520148 0.0116219065669638 no 176 0.00149756308367463 72 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_104 0074-0074 590.992 µM 2.96116225377006 0.0117870900874144 no 177 0.00153240216764376 29 3943124
SGTC_34 0469-0683 81.75 µM 2.94764796097689 0.0121082635418976 no 178 0.00160100738858091 75 3690923
SGTC_163 TUB2.036 7.546 µM 2.94553557615096 0.0121591448745513 no 179 0.00161198035014605 197 15992207 YJR013W GPI14
SGTC_2073 5212005 126 µM 2.94166711143765 0.0122528057503915 no 180 0.00163225324576938 29 691789
SGTC_918 glabranin 770.725 nM 2.93917342063018 0.0123135122804629 no 181 0.00164544440594347 81 124049 Also referred to as licorice root.
SGTC_1636 st007707 68.9 µM 2.93904713631316 0.0123165934718862 no 182 0.00164611500269211 103 403051
SGTC_1067 clotrimazole 1.36 µM 2.93658750057324 0.0123767390788144 no 183 0.00165922593798018 91 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3078 9116413 49.47 µM 2.93616721100185 0.0123870418519278 no 184 0.00166147575629619 82 17177322
SGTC_2820 7989630 71.43 µM 2.92932739265018 0.0125557569068323 no 185 0.00169848210071181 65 2984098
SGTC_3143 9086658 49.47 µM 2.9192534376646 0.0128078685408458 no 186 0.00175435418338112 112 25236626
SGTC_2336 9001819 198.65 µM 2.91723985978682 0.0128587822898818 no 187 0.00176572044479806 113 2989602
SGTC_2767 sibutramine 71.45 µM 2.90290265584154 0.0132263877922812 no 188 0.00184860768904503 67 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1563 conessine 56.1 µM 2.89156147229784 0.0135235735635645 no 189 0.00191666296227552 63 441082 An anti-amoebic, histamine inhibitor.
SGTC_2271 7849410 118.62 µM 2.88385334092409 0.0137288330642024 no 190 0.0019642082971898 49 972430
SGTC_2260 7964312 200 µM 2.88183867877368 0.0137829223990039 no 191 0.00197681046613907 57 231951
SGTC_2899 9053889 58.44 µM 2.87137309052538 0.0140668679117374 no 192 0.00204346424906577 36 6470052
SGTC_522 1273-0010 11.6 µM 2.86720178319258 0.0141814383345671 no 193 0.00207059441621173 71 5705015
SGTC_758 0868-0029 16 µM 2.86079793344118 0.014358892759662 no 194 0.00211288146194592 45 762687
SGTC_687 k029-0044 34.9 µM 2.85503727710292 0.0145201542979447 no 195 0.00215158889124586 64 5829338
SGTC_1194 1488-0194 225 µM 2.84249027196661 0.0148767929518739 no 196 0.00223812985745087 94 1391452
SGTC_966 1300-0360 30.2 µM 2.83480480784213 0.0150989453083884 no 197 0.0022926846168426 81 70588
SGTC_1824 st053723 68.6 µM 2.83265901976405 0.0151614772024785 no 198 0.00230812994699441 91 675225
SGTC_1529 apigenin 74 µM 2.82480460603421 0.015392269492533 no 199 0.0023654728186986 96 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1804 st050076 49.1 µM 2.8213408516635 0.0154950022155673 no 200 0.00239116800042331 71 3895976
SGTC_1034 k072-0165 12.7 µM 2.81841040984402 0.0155823762927225 no 201 0.00241310386940415 84 5835461
SGTC_3176 9106582 49.47 µM 2.8166016766511 0.0156365162443097 no 202 0.0024267338830452 12 17018027
SGTC_3051 9093778 49.47 µM 2.81482766286995 0.0156897736589424 no 203 0.00244016988417437 25 17217378
SGTC_3221 9128209 49.47 µM 2.81093349866274 0.0158072257621358 no 204 0.00246989973465817 70 16460723
SGTC_233 rapamycin 362 pM 2.7840649335374 0.0166383414493591 no 205 0.00268411429775386 48 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_194 1486-1323 56.904 µM 2.78334826166379 0.0166610125482805 no 206 0.00269005108725002 67 5178754
SGTC_2497 7-hydroxyflavone 100 µM 2.76618520091243 0.0172118959970681 no 207 0.00283581571852523 77 5281894
SGTC_1644 st010134 20.9 µM 2.75596631123596 0.0175472267839054 no 208 0.00292595119531775 51 3818134
SGTC_52 0329-0193 875 nM 2.74665490941221 0.0178576189534557 no 209 0.0030103223094817 91 3739292
SGTC_879 0831-1030 162 µM 2.74595450661872 0.017881154842749 no 210 0.00301675647667714 147 1549252
SGTC_627 1391-0720 175 µM 2.74581888816752 0.0178857151348444 no 211 0.00301800375025492 68 997839
SGTC_1139 k015-0024 46.9 µM 2.72496428163641 0.0185988751188431 no 212 0.00321542218478518 55 2766652
SGTC_22 0964-0034 14.468 µM 2.70536264751832 0.0192911169801438 no 213 0.00341149289710719 129 138402
SGTC_3132 9126706 49.47 µM 2.70207105453043 0.0194094824947493 no 214 0.00344545172435788 97 850858
SGTC_743 1275-0778 158 µM 2.69795293353644 0.0195584382805497 no 215 0.00348836519580609 130 2849257 YMR203W TOM40
SGTC_2124 5246320 200 µM 2.69302881585469 0.0197378210131344 no 216 0.00354030745262437 93 579342
SGTC_3101 9120531 49.47 µM 2.68816904850759 0.0199162269352333 no 217 0.00359225072173955 116 24824904
SGTC_2480 5767542 37.17 µM 2.68303732076099 0.020106100163667 no 218 0.00364784241148518 68 2867358
SGTC_2833 9001315 45.46 µM 2.68262413998328 0.0201214543554713 no 219 0.00365235177656273 135 2989378
SGTC_2441 5730946 39.09 µM 2.68178876331821 0.020152528127795 no 220 0.00366148417758175 92 1774275
SGTC_3188 9110789 49.47 µM 2.68040996903798 0.0202039045892239 no 221 0.00367660208159354 98 849217
SGTC_604 1000-0114 314 µM 2.67618567980729 0.0203620014003658 no 222 0.00372326886963574 96 1572745
SGTC_3284 9108171 64.8615 µM 2.65740048849682 0.0210778071515602 no 223 0.00393729172140327 88 8687505
SGTC_882 0843-0131 351 µM 2.64973307591866 0.0213760314903111 no 224 0.00402776933223341 95 5425421
SGTC_168 3970-0862 530.542 µM 2.6481835564821 0.0214367314774741 no 225 0.00404627861003519 291 3135186
SGTC_3254 9136651 49.47 µM 2.64507047113384 0.0215591222225843 no 226 0.00408369527540031 79 16454030
SGTC_53 0973-0023 39.979 µM 2.62089557517755 0.0225298034030181 no 227 0.00438495601659836 82 674768
SGTC_2354 9060492 162 µM 2.61773951842392 0.0226592054978675 no 228 0.00442571720476702 103 6471895
SGTC_2187 6125751 200 µM 2.60956860152195 0.0229971363623938 no 229 0.00453282334685477 97 874498
SGTC_868 0527-0199 213 µM 2.60803869001936 0.0230608795860793 no 230 0.00455313305434418 102 2849450
SGTC_2963 9082507 9 µM 2.58528672614926 0.024026525834303 no 231 0.00486490234381782 100 16459611
SGTC_1656 st012921 11 µM 2.58029182984441 0.0242430088577974 no 232 0.00493584267129729 95 6732821
SGTC_2828 7998861 71.43 µM 2.57009133792243 0.0246901979208372 no 233 0.00508358522555643 75 2988188
SGTC_2885 9057732 51.95 µM 2.56492830687432 0.0249191701719315 no 234 0.00515985627474605 94 6471414
SGTC_1678 st019265 80.2 µM 2.55656078343485 0.0252940366504464 no 235 0.00528563001757645 123 5367020
SGTC_276 colchicine 750 µM 2.55650678075003 0.0252964712404134 no 236 0.00528645052094925 110 2833 A microtubule depolymerizer.
SGTC_212 3807-4682 38.772 µM 2.55328143759144 0.0254422350436235 no 237 0.00533566148953989 195 3125501 YBL034C STU1
SGTC_1685 st024049 53.0905 µM 2.55044376813462 0.0255710596989565 no 238 0.00537929390398387 86 1941139
SGTC_2396 5342950 42.78 µM 2.5486710790917 0.0256518131501756 no 239 0.00540671173489173 160 1886677
SGTC_1024 4507-0395 26 µM 2.54808165110489 0.0256787113271956 no 240 0.00541585578174093 126 4201836
SGTC_1028 k015-0029 4.8 µM 2.54524420933493 0.0258085268177076 no 241 0.00546006686043514 135 4588309
SGTC_2092 5303694 80.6725 µM 2.53449069797209 0.0263055046167052 no 242 0.00563054584100037 143 1963699
SGTC_291 SEC14.278 35.5 µM 2.53036292819367 0.0264983841054666 no 243 0.00569722984225319 80 1068044
SGTC_2097 5376186 200 µM 2.52329702457941 0.0268312969846247 no 244 0.00581300777588248 120 742755
SGTC_1809 st050081 57.6 µM 2.51764766418662 0.0270999746471743 no 245 0.00590707181132325 114 5036894
SGTC_2428 5615643 7.78 µM 2.50292642110347 0.027810665779891 no 246 0.00615855739251367 112 2253075
SGTC_3006 9075424 71.4286 µM 2.47625622045887 0.0291377563087003 no 247 0.00663841297160303 108 7465181
SGTC_2198 6589944 200 µM 2.47158022159256 0.0293757670233718 no 248 0.0067258683349077 73 5290268
SGTC_1168 k815-0004 80.5 µM 2.47132821308431 0.0293886400973861 no 249 0.00673061044097953 99 642433
SGTC_811 0416-0114 265 µM 2.47104028927609 0.0294033535259052 no 250 0.0067360319900075 135 6612453
SGTC_1116 jasmonic acid 1.58368 µM 2.46843808698414 0.0295366084121024 no 251 0.00678520625796902 119 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1228 0124-0032 52.5 µM 2.46839650272412 0.0295387419424781 no 252 0.00678599465081893 126 X1228
SGTC_1261 0712-0010 12.7 µM 2.46547283857539 0.0296890650202033 no 253 0.00684162744760274 141 2840123
SGTC_744 1594-0068 283 µM 2.46037258459624 0.0299528190247842 no 254 0.00693964224227073 151 668392
SGTC_14 0354-0009 295 µM 2.46034209634525 0.029954401514944 no 255 0.00694023186271824 121 1713507
SGTC_3296 9122258 64.045 µM 2.45244585254767 0.030366596182137 no 256 0.00709443662158562 125 4730474
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.44735249879729 0.030634961499246 no 257 0.00719550079250561 135 688761
SGTC_3218 9131285 49.47 µM 2.42623176748288 0.0317688396901381 no 258 0.00762826181211073 190 17156417
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.41385063886583 0.0324494978998958 no 259 0.00789246579847722 81 688803
SGTC_1860 st056228 74.6 µM 2.40892970888883 0.0327233488195765 no 260 0.00799968955686516 119 688679
SGTC_2857 9024691 58.44 µM 2.39222121388825 0.0336674346248303 no 261 0.00837337266947101 135 16478292
SGTC_1552 6-methylflavone 10.6 µM 2.39202658487679 0.0336785625064586 no 262 0.00837781433018144 90 689013
SGTC_531 3788-1495 174 µM 2.38836493020955 0.033888481739609 no 263 0.00846176393189387 149 2896655
SGTC_936 3005-4620 401 µM 2.38724372213382 0.0339529743686112 no 264 0.00848761673377441 161 777207
SGTC_2876 9059903 25.97 µM 2.38543448117943 0.0340572559480469 no 265 0.00852948037198987 113 6916095
SGTC_190 3970-0790 3.722 µM 2.38044597840549 0.0343461496364874 no 266 0.00864584811171698 94 2832352
SGTC_377 3970-0964 33.1 µM 2.37665028013704 0.0345673123370981 no 267 0.00873532159730163 217 16481235
SGTC_2128 5255449 168.493 µM 2.37598356695421 0.0346062800195682 no 268 0.00875112113112886 167 736008
SGTC_1996 st072960 66.8 µM 2.37200284277293 0.0348396946764964 no 269 0.0088459772965516 114 1719405
SGTC_206 4546-0025 72.014 µM 2.36830038987083 0.0350579511967741 no 270 0.00893501016300622 209 6620745 YIL048W NEO1
SGTC_459 nigericin 15.3 µM 2.36390143271493 0.0353187232451001 no 271 0.00904181158009026 190 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_493 zm226600 134 µM 2.35356878960351 0.0359375074389185 no 272 0.00929708354411362 138 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1512 0259-0544 12.2 µM 2.34437941675624 0.0364952602844997 no 273 0.00952938610496115 162 18476
SGTC_1299 1079-1439 3.74 µM 2.34379983730455 0.0365306742516794 no 274 0.00954420623207764 120 323161
SGTC_3201 9113999 49.47 µM 2.34280931912675 0.0365912628394668 no 275 0.00956958090875143 158 16649224
SGTC_3269 9137823 49.47 µM 2.34248499921212 0.0366111188839015 no 276 0.00957790200535746 122 17682936
SGTC_1872 amphotericin b 148 nM 2.33836277956588 0.0368642650216795 no 277 0.009684218420094 143 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1487 3970-0795 2.82 µM 2.33149628351035 0.0372891138536348 no 278 0.00986360290695571 127 3765103
SGTC_1604 st002052 72.4 µM 2.33085819927945 0.0373287961735502 no 279 0.00988041903072997 133 6254834 YHR062C RPP1
SGTC_1408 3909-7976 48.8 µM 2.32602509043195 0.037630487631355 no 280 0.0100086061052835 163 24152374
SGTC_707 0865-0008 204 µM 2.32284720078724 0.0378299398936378 no 281 0.0100936811923473 115 723043
SGTC_2868 9035608 32.47 µM 2.31859394801423 0.038098233796424 no 282 0.0102085317871284 146 6462614
SGTC_1264 0783-0040 158 µM 2.31437800369087 0.0383657039303091 no 283 0.0103234981910913 150 2855798
SGTC_3026 9090633 49.47 µM 2.31316234669286 0.0384431119899528 no 284 0.0103568574536534 151 25236842
SGTC_3107 9121808 49.47 µM 2.30533648699821 0.0389444833775877 no 285 0.0105738677851105 81 662681
SGTC_1084 voriconazole 435 nM 2.30187071669549 0.0391682161790553 no 286 0.0106712320293947 144 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_347 4534-1311 26.2 µM 2.30120291371116 0.039211446184419 no 287 0.0106900821419915 135 2862016
SGTC_2009 4012297 12.05 µM 2.29791349053803 0.039424952977054 no 288 0.0107833566587807 181 45595307
SGTC_808 0711-0032 135 µM 2.29726444891117 0.0394671918767706 no 289 0.0108018442702904 129 4252555
SGTC_325 2810-4341 181 µM 2.29723504392432 0.0394691063916182 no 290 0.0108026825089259 106 774970
SGTC_1728 st035614 33.7865 µM 2.29591621305829 0.0395550512118819 no 291 0.0108403362714475 225 15945546
SGTC_2170 morpholine 200 µM 2.28733308667257 0.0401181170211126 no 292 0.0110881943345147 119 121171 Reacts with secondary amines.
SGTC_3235 9132602 49.47 µM 2.28614563718307 0.0401965257413513 no 293 0.0111228699341968 160 4912240
SGTC_57 miconazole 162.5 nM 2.28496277463342 0.0402747552990799 no 294 0.0111575053026028 148 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_330 1488-0319 80.1 µM 2.28415564159476 0.0403282066284415 no 295 0.0111811927367828 133 6846614
SGTC_1457 k015-0032 57.3 µM 2.2810912990187 0.0405316634877311 no 296 0.0112715224532189 182 4302660
SGTC_605 1315-0399 119 µM 2.26477762070316 0.0416288774683405 no 297 0.0117631647096718 164 24020461
SGTC_61 0978-8327 98.565 µM 2.26160629474773 0.0418449406264611 no 298 0.0118608693777166 166 6150059 YHR072W ERG7
SGTC_797 k781-0471 270 µM 2.24842003444777 0.0427530798421605 no 299 0.0122747094317205 154 23738129
SGTC_2080 5212524 12.4 µM 2.24763182906724 0.0428078643490973 no 300 0.0122998381153535 125 260183
SGTC_96 0929-0093 37.281 µM 2.24324130911919 0.0431140681893322 no 301 0.0124406288953537 139 6991579
SGTC_355 1311-2252 105 µM 2.24209014279034 0.0431946449643667 no 302 0.0124777734735341 182 5338538
SGTC_394 menadione 8.33 µM 2.23804820226305 0.0434785274055209 no 303 0.0126089559674624 165 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2692 st077426 47.7 µM 2.23091717999276 0.0439830399896967 no 304 0.0128433077563075 162 25238571
SGTC_933 2914-0560 114 µM 2.22905992799516 0.0441152107011561 no 305 0.0129049588405131 189 463887
SGTC_3024 9090631 49.47 µM 2.22862712002155 0.0441460572955365 no 306 0.0129193625232741 95 25236383
SGTC_965 1291-5240 308 µM 2.2284878301253 0.0441559883033057 no 307 0.0129240009934387 170 2834598
SGTC_1983 st071813 46.9 µM 2.2198760112619 0.0447734948415596 no 308 0.0132135926588699 147 11838595
SGTC_1603 st002045 67.8 µM 2.21759635848634 0.0449381150648295 no 309 0.0132911832061295 140 5887985
SGTC_2735 sertaconazole 140 nM 2.20468083933602 0.0458800023422882 no 310 0.0137382493014763 96 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2467 5474540 200 µM 2.20014633222855 0.0462144276903237 no 311 0.0138982572727832 171 5413519
SGTC_129 0088-0017 176.636 µM 2.19711800393347 0.046438858751069 no 312 0.0140060098077428 222 182446
SGTC_181 1447-1644 8.07 µM 2.18931193341961 0.0470214064949381 no 313 0.0142870877968679 177 534600
SGTC_1059 3448-6867 171 µM 2.18871005812523 0.0470665651943619 no 314 0.0143089602331287 146 3934407
SGTC_2487 5918373 44.05 µM 2.18734670361971 0.0471689862696184 no 315 0.0143586118597815 165 2876279
SGTC_1896 st058441 89 µM 2.18667049498807 0.04721985222321 no 316 0.0143832935057019 157 688759
SGTC_1707 st032323 6.317 µM 2.18570244558416 0.0472927476188527 no 317 0.0144186909313612 231 3132057 YMR211W DML1
SGTC_2348 9022543 33.42 µM 2.18126131200001 0.0476283275363372 no 318 0.0145820471064515 180 3162678 YDL140C RPO21
SGTC_27 0485-0001 32.618 µM 2.14875471297121 0.0501430119998366 no 319 0.0158269245227052 98 2054479
SGTC_2054 5233173 129 µM 2.13565998711867 0.0511854502725929 no 320 0.0163535690317977 265 6889
SGTC_2980 9014342 25.29 µM 2.13231777924802 0.0514542586764167 no 321 0.0164903657138399 180 2996599
SGTC_2696 st077691 74.316 µM 2.13161386412494 0.0515110163158893 no 322 0.0165193015314858 176 757133
SGTC_1003 4049-0218 100 µM 2.12716536147086 0.0518708575281807 no 323 0.0167031730336347 227 295161
SGTC_1038 k292-0204 154 µM 2.12623728902624 0.0519461809554609 no 324 0.0167417533468052 168 4454212
SGTC_1466 k213-0079 57.5 µM 2.12480222021097 0.052062823859617 no 325 0.0168015597502929 190 3657981
SGTC_1323 1348-1351 11.2 µM 2.12184890143041 0.0523035253216693 no 326 0.0169252143076978 146 6989654
SGTC_268 camptothecin 39.6153 µM 2.11830170126829 0.0525937964478919 no 327 0.0170747623271881 309 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1214 0358-0031 63.7 µM 2.11783453542304 0.0526321202139752 no 328 0.0170945416985694 197 4301366
SGTC_960 1222-0186 7.7 µM 2.11313429629534 0.0530189367718297 no 329 0.0172946374829054 195 3126296
SGTC_2164 5685496 200 µM 2.10651511326432 0.0535674961115852 no 330 0.017579815856602 171 759046
SGTC_1037 k284-1091 78.7 µM 2.09729497784694 0.0543390899094158 no 331 0.0179837355854384 168 3334711
SGTC_1358 1509-0022 2.48 µM 2.09121081329077 0.0548530448757043 no 332 0.0182545852149384 180 3258434
SGTC_107 0358-0022 2.6945 µM 2.08643753703359 0.0552589470158961 no 333 0.0184695038761726 121 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2798 7813637 45.45 µM 2.08598753135983 0.0552973359157666 no 334 0.0184898762613737 211 956368
SGTC_2845 9003024 42.97 µM 2.08405838669675 0.055462145333555 no 335 0.018577428324181 252 2990173
SGTC_1929 genistein trimethyl ether 50.5 µM 2.08026395923638 0.0557874397264903 no 336 0.0187506643029587 186 136420
SGTC_1474 0330-0125 5.35 µM 2.07783782667175 0.0559962186473073 no 337 0.0188621492642174 173 X1474
SGTC_2641 levomentholum 100 µM 2.07011522459821 0.056664886074794 no 338 0.0192207777515493 118 16666
SGTC_527 4476-4215 268 µM 2.06377403735883 0.057218632424101 no 339 0.01951957289127 227 4418754
SGTC_3083 9117465 49.47 µM 2.05828204411941 0.057701656324895 no 340 0.0197815334077758 232 16420915
SGTC_2519 cryptotanshinone 88.04 µM 2.05723499887062 0.0577941074176824 no 341 0.0198318132364182 151 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2188 6126565 140.678 µM 2.05631896721949 0.0578750858622726 no 342 0.0198758906160996 149 874518
SGTC_823 0417-1665 178 µM 2.05386450999238 0.058092502921025 no 343 0.019994403558823 216 3429856
SGTC_2611 pyromycin 23.93 µM 2.0519277437038 0.0582645152605561 no 344 0.0200883425663065 223 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1691 st019933 84.6 µM 2.05095649877 0.0583509260974096 no 345 0.0201355916324701 168 6176082
SGTC_3187 9109394 49.47 µM 2.04885489521843 0.0585382485036411 no 346 0.0202381529973407 235 17098090
SGTC_1032 k061-1018 98.7 µM 2.04056902086351 0.0592813981035967 no 347 0.0206468420193089 248 4005393
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.03075338273528 0.0601712999468669 no 348 0.0211400090610601 181 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1620 st003704 16.5 µM 2.02408890497655 0.0607814497022977 no 349 0.0214805024976304 172 2834414
SGTC_2190 6049624 200 µM 2.02379283512721 0.0608086674804139 no 350 0.0214957358698108 145 2265554
SGTC_2002 4023503 131 µM 2.01929798699927 0.0612230517520179 no 351 0.0217281284970755 281 4736863 YCR052W RSC6
SGTC_2997 9067075 71.4286 µM 2.01559487267117 0.061566100371139 no 352 0.0219211781890693 255 27209819
SGTC_2898 9056270 58.44 µM 1.99797319574033 0.0632191418477775 no 353 0.0228597830853398 147 19154699
SGTC_1481 3346-2004 36 µM 1.99538835079038 0.0634644987775918 no 354 0.0230002702384401 204 2770522
SGTC_1008 4106-0037 6 µM 1.99183807088085 0.0638027033479877 no 355 0.0231944138088202 187 2905394
SGTC_3036 9090181 49.47 µM 1.98919637717552 0.0640552631309508 no 356 0.0233397658200434 151 25236586
SGTC_3251 9135047 49.47 µM 1.98336192560074 0.0646158209806144 no 357 0.0236635084221434 151 17682963
SGTC_3116 9124943 49.47 µM 1.98008480059114 0.0649323449486302 no 358 0.0238470003778268 217 41905195 YPL160W CDC60
SGTC_2224 6650123 117.647 µM 1.96453194298392 0.0664509681110236 no 359 0.0247342178300196 149 2908370
SGTC_2225 6654152 15.4 µM 1.96140756487656 0.0667593315627116 no 360 0.0249157491202158 150 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_273 hydroxyurea 18.1 mM 1.9552556937906 0.0673697314333224 no 361 0.025276448947223 296 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2970 9090938 41.86 µM 1.95466165793541 0.0674289004072473 no 362 0.0253115092486158 332 17217104
SGTC_481 bay k-8644 50 µM 1.94211423456701 0.0686880926303887 no 363 0.0260616363263235 225 2303 A calcium channel antagonist.
SGTC_2848 9016370 25.97 µM 1.94063860394145 0.0688373629456749 no 364 0.0261510640942856 261 7894410
SGTC_2076 5212012 200 µM 1.93600685066251 0.069307521787712 no 365 0.0264334309654718 142 604802
SGTC_625 k213-0058 121 µM 1.93580886972214 0.0693276733782082 no 366 0.0264455570953101 414 3655420
SGTC_1212 0520-0165 585 µM 1.93564717775989 0.0693441346246681 no 367 0.0264554640106889 249 5403258
SGTC_2305 7443522 69.23 µM 1.93338024056349 0.0695752400392454 no 368 0.0265946867866961 232 5415886
SGTC_1403 3909-7815 62.9 µM 1.93224840095179 0.0696908484205528 no 369 0.0266644268937654 183 6615483
SGTC_1928 4'-methoxychalcone 40.3 µM 1.93218541821701 0.0696972859449882 no 370 0.0266683121580642 197 641818
SGTC_769 0302-0231 76 µM 1.92911492080675 0.070011679840008 no 371 0.0268582985313489 321 571869 YER009W NTF2
SGTC_995 3931-2021 34.6 µM 1.92191986935143 0.0707526676479473 no 372 0.027307920634258 241 730143
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.91688271354617 0.0712749987293442 no 373 0.0276264168275808 296 442882
SGTC_1521 st012942 49.4 µM 1.91344790810587 0.0716328671440695 no 374 0.0278453681114604 273 24207259
SGTC_1834 st055981 52.8 µM 1.9079911550406 0.0722042324087341 no 375 0.028196179739311 258 471719 YDL150W RPC53
SGTC_78 0336-0123 156.75 µM 1.90460432902277 0.0725606127004395 no 376 0.0284157617239061 218 6765896
SGTC_1424 4048-1941 275 µM 1.90112416014379 0.072928216971023 no 377 0.0286428758667011 276 X1424
SGTC_2482 5981709 142.65 µM 1.89699822532605 0.0733658773180138 no 378 0.0289140861584444 289 877755
SGTC_1606 st000094 49.2 µM 1.89612805070515 0.0734584374789104 no 379 0.0289715571074637 249 1242210
SGTC_1520 flindersine 88 µM 1.89511517626344 0.0735662890121415 no 380 0.0290385722415979 267 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_313 3474-0040 5.03 µM 1.89200655308771 0.0738980533098192 no 381 0.029245053847342 346 1043375 YIL048W NEO1
SGTC_1790 st045711 43.5 µM 1.89100809476526 0.0740048548779778 no 382 0.0293116318350131 229 585119
SGTC_2796 7949634 45.45 µM 1.87816834323886 0.0753888075387125 no 383 0.0301790696639077 261 2971588
SGTC_300 r073-0011 5.04 µM 1.87623196991197 0.0755992232810756 no 384 0.0303117169645052 290 2735780
SGTC_2161 5662504 8.5105 µM 1.87466181205978 0.0757701725505324 no 385 0.0304196318307778 249 2859334
SGTC_2923 7992654 58.14 µM 1.87337705463559 0.0759102680437268 no 386 0.0305081681120456 272 2985126
SGTC_3261 9137475 49.47 µM 1.8704565218233 0.0762294692869486 no 387 0.0307102246348818 95 17027690
SGTC_930 2810-3379 265 µM 1.8664718724541 0.0766666200593949 no 388 0.030987687883374 287 1015764
SGTC_1124 fisetin 1.16336 µM 1.86600476185846 0.0767179907577425 no 389 0.0310203496380709 254 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2060 5238662 140 µM 1.85270149087015 0.078192036152827 no 390 0.0319625781102836 255 790130
SGTC_1859 st055998 20 µM 1.85055408682605 0.0784319757572028 no 391 0.0321168650586101 268 676301
SGTC_992 3909-8734 162 µM 1.84609759253945 0.0789317016535389 no 392 0.0324390181794375 251 4288319
SGTC_775 4577-0580 57.3 µM 1.8387839150263 0.0797570374531479 no 393 0.0329734875073133 244 2006902
SGTC_2676 harmalol 100 µM 1.8376844727488 0.0798816699652538 no 394 0.0330544565927529 262 5459187 A monoamine oxidase inhibitor
SGTC_1224 0823-0416 294 µM 1.831258866643 0.0806130226047392 no 395 0.0335309570216972 266 3598164
SGTC_3137 9097352 49.47 µM 1.82992385398323 0.0807656042361408 no 396 0.0336306629693741 333 44120435
SGTC_1322 1348-1070 12 µM 1.82825378460253 0.0809567871722312 no 397 0.0337557361779948 215 6758089
SGTC_3114 9122766 49.47 µM 1.8280778330453 0.080976949284742 no 398 0.0337689356268016 261 17176985
SGTC_414 piperonyl butoxide 100 µM 1.82620886019189 0.0811913470136881 no 399 0.0339094036240567 229 5794 A potent inhibitor of cytochrome P450.
SGTC_703 3875-0075 71.8 µM 1.82334525253946 0.0815206739498948 no 400 0.0341255582767004 224 2850814
SGTC_722 3534-0461 190 µM 1.82190261102432 0.0816869648937897 no 401 0.0342348820380718 295 658262
SGTC_778 3456-2434 196 µM 1.81441978930417 0.0825536029846275 no 402 0.0348065606729207 368 5539063
SGTC_1387 3342-1166 1.8 µM 1.8099331652097 0.0830765390255606 no 403 0.0351530761262487 183 3418228
SGTC_365 0121-0052 13.6 µM 1.80920286105553 0.0831618944691669 no 404 0.0352097466616127 396 3101739
SGTC_1784 st039334 36.3 µM 1.80896462863325 0.083189752516802 no 405 0.035228249353623 269 3496984
SGTC_2337 9009472 200 µM 1.80858908007561 0.0832336820707702 no 406 0.0352574331140031 327 5742383
SGTC_2507 purpurin 79.67 µM 1.80505039909539 0.0836484738296626 no 407 0.0355333978791152 303 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2745 rifampicin 24.3 µM 1.80352603935768 0.0838276317696404 no 408 0.0356528198808245 151 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1596 piperlongumine 63 µM 1.80305643846753 0.0838828819713758 no 409 0.0356896757546942 291 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1238 0333-0287 48.8 µM 1.79927742722931 0.0843284919151519 no 410 0.0359874034573764 277 7226
SGTC_3313 9133968 57.047 µM 1.79846352600456 0.0844246968419739 no 411 0.0360517918286046 301 1494643
SGTC_1433 4060-0023 7.6 µM 1.79835042648891 0.0844380719691868 no 412 0.0360607466827016 269 3840627
SGTC_2700 st077718 96.8 µM 1.79670157466656 0.0846332454525531 no 413 0.0361915044252445 234 904970
SGTC_346 4513-0042 7.16 µM 1.78820110303479 0.0856448122272624 no 414 0.0368717842055305 313 2827372
SGTC_309 k408-0051 1.48 µM 1.78565628148634 0.0859494029127757 no 415 0.0370774640467563 375 3640463
SGTC_149 3970-0822 46.1 µM 1.78318584571512 0.0862458650612286 no 416 0.0372780278858938 461 3114250 YBL034C STU1
SGTC_46 0329-0187a 2.197 µM 1.78109483110286 0.0864973922450039 no 417 0.0374484800095987 403 46494817
SGTC_735 3076-0345 636 µM 1.77073119897206 0.0877521282727698 no 418 0.0383027058708564 349 2888990
SGTC_941 3237-0776 460 µM 1.77064740732573 0.0877623280583087 no 419 0.0383096766324073 265 760008
SGTC_2671 danthron 100 µM 1.76719636032982 0.0881831856297239 no 420 0.0385976745210034 293 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2177 5811945 192 µM 1.76031021469505 0.0890274486241884 no 421 0.0391776115928283 292 5343475
SGTC_2453 5731132 22.18 µM 1.75944395982792 0.0891340787719519 no 422 0.039251065420975 306 1362040
SGTC_1170 0310-0127 64.8 µM 1.75757422692007 0.0893645542290666 no 423 0.0394099909188294 327 774975
SGTC_31 0508-1974 57.237 µM 1.74512545384101 0.0909103837023514 no 424 0.0404815168683102 291 6810525
SGTC_403 arphamenine a 50 µM 1.74345768755308 0.0911189767856457 no 425 0.0406268495716217 312 5487158 An arginine aminopeptidase inhibitor.
SGTC_1699 st031318 29.054 µM 1.73903602678746 0.0916737263487441 no 426 0.0410142130437017 293 5340658
SGTC_332 4112-0506 40.9 µM 1.73813510013393 0.0917870644719951 no 427 0.041093505698839 289 2790355
SGTC_1729 st035615 45.989 µM 1.7338070863669 0.0923329833610887 no 428 0.0414761589468884 322 17385451
SGTC_1892 st058411 7.36 µM 1.72760357190214 0.0931196558184222 no 429 0.0420296609979276 363 3934738
SGTC_1525 8-methoxypsoralen 92.5 µM 1.71887884091261 0.0942344123889677 no 430 0.0428182178460474 360 4114 Related to psoralen; DNA damaging agent.
SGTC_1927 st060202 13.8 µM 1.71585472088314 0.0946230916430173 no 431 0.0430943178983402 293 688887
SGTC_887 0885-0007 9.62 µM 1.71177933294369 0.0951487541309878 no 432 0.0434686710574339 347 5719458
SGTC_2192 5915882 198.485 µM 1.69954645198353 0.0967395196099474 no 433 0.0446081349782773 260 2876149
SGTC_1762 st045503 25.4615 µM 1.69892372781244 0.0968210180733524 no 434 0.0446667778031542 333 4645554
SGTC_2375 9072683 200 µM 1.69836227539235 0.0968945408608905 no 435 0.0447197037920425 352 16798029
SGTC_1862 st057513 3.81 µM 1.69323820635899 0.0975674380781826 no 436 0.0452050674527496 304 5393163
SGTC_1546 5-methoxyflavanone 78.7 µM 1.69254679159965 0.0976584970328294 no 437 0.0452708831830251 314 147795
SGTC_1054 3429-0080 167 µM 1.6911010851204 0.097849097138389 no 438 0.045408749004474 367 1162877
SGTC_2141 5621638 7.665 µM 1.68852313067541 0.0981896477351961 no 439 0.0456554263065823 310 2856238
SGTC_1335 1486-0900 202 µM 1.68581178328372 0.0985487556303033 no 440 0.0459160287397088 369 X1335
SGTC_1300 1094-0077 113 µM 1.68464848309386 0.0987031248357309 no 441 0.0460282056863892 290 5532636
SGTC_3131 9127911 49.47 µM 1.68371810299378 0.098826713006264 no 442 0.0461180805288491 329 45595681
SGTC_759 3486-0358 89.3 µM 1.68354332969184 0.0988499418580934 no 443 0.0461349793690308 356 875103
SGTC_1107 amlodipine 47 µM 1.67360466172959 0.100177455905852 no 444 0.0471041608689916 354 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1590 st077108 57.8 µM 1.66596268429679 0.101207015912206 no 445 0.0478604235183401 294 5489485
SGTC_1651 st011928 86.1 µM 1.66580472279385 0.101228378197851 no 446 0.0478761575905116 312 720198
SGTC_110 0850-0284 111.64 µM 1.66563192937092 0.101251750074795 no 447 0.0478933737679744 212 3906265
SGTC_1241 0364-0022 50.8 µM 1.66391737380228 0.101483872353715 no 448 0.0480644712639383 369 4563895
SGTC_532 1548-0774 215 µM 1.66107972801029 0.101868893495376 no 449 0.0483487176400563 354 5932993
SGTC_1811 st050069 61.5 µM 1.66030316748393 0.101974444843202 no 450 0.0484267394229735 265 3877702
SGTC_73 0327-0325 16.231 µM 1.65786253998016 0.102306696932142 no 451 0.0486726073237273 415 53298
SGTC_1350 1495-0454 146 µM 1.65579817677764 0.102588340740109 no 452 0.048881348572285 402 1069057
SGTC_465 cgp-37157 41 µM 1.65335110494753 0.102922927525994 no 453 0.0491297138847926 215 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_462 ag-879 158 µM 1.65092590811273 0.103255304851504 no 454 0.0493768524167018 382 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_114 0364-0001 490.298 µM 1.64908884297562 0.103507596013411 no 455 0.0495647175036004 375 4003655
SGTC_2918 7977171 22.06 µM 1.64526818547372 0.104033733666007 no 456 0.0499572588165679 328 2236483
SGTC_2411 st077133 39.94 µM 1.64037414209537 0.104710515187137 no 457 0.0504636991837531 412 1403142 YNL221C POP1
SGTC_3129 9127257 49.47 µM 1.63950464695508 0.104831087694276 no 458 0.0505541018405076 319 837894
SGTC_2643 anethole 100 µM 1.63875014544843 0.104935795523464 no 459 0.0506326529485966 374 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2471 5466956 24.79 µM 1.63739795830825 0.105123638064162 no 460 0.0507736722766867 300 724419
SGTC_2722 naftopidil 47.16 µM 1.63578585366369 0.105347905570907 no 461 0.050942206856826 340 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2065 5221596 34.26 µM 1.62622191750844 0.106685509854312 no 462 0.0519512276316286 345 788581
SGTC_1090 efavirenz 20.7 µM 1.62434286313438 0.106949747262034 no 463 0.052151327027192 340 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3246 9135460 32.98 µM 1.61832455498423 0.107799233934432 no 464 0.0527963357802664 277 41446951
SGTC_1252 0493-0875 34.8 µM 1.61490234301961 0.108284442725054 no 465 0.0531659223961388 366 3960963
SGTC_2003 4023581 200 µM 1.61026763501134 0.108944064797306 no 466 0.0536697208045228 371 16641307
SGTC_1888 azatryptophan 97.5 µM 1.60726537749454 0.109372891493746 no 467 0.0539980829225172 303 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2133 5320837 200 µM 1.60490824625135 0.109710420401676 no 468 0.054256999261112 360 2841355
SGTC_3330 9141424 71.43 µM 1.60158636312296 0.110187365251761 no 469 0.0546235541727821 397 27261020
SGTC_982 1491-0518 27.5 µM 1.60154831931594 0.110192836054301 no 470 0.0546277634493861 325 3091256
SGTC_1303 1160-0052 261 µM 1.59557797727149 0.111053803284316 no 471 0.0552915238261445 378 3562476
SGTC_2544 sphondin 68.51 µM 1.59516260328059 0.111113882021324 no 472 0.055337939518235 342 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_141 0443-0274 32.331 µM 1.59318146744276 0.111400749180233 no 473 0.0555597437367926 507 1627241
SGTC_3335 9143315 29.6265 µM 1.58930117805212 0.111964147561622 no 474 0.055996206458711 363 4899691
SGTC_1409 3909-8004 61.9 µM 1.5871951833203 0.112270778902274 no 475 0.0562342226727626 393 2119279
SGTC_2461 5755302 26.15 µM 1.57876330914353 0.113504464204505 no 476 0.0571951786793247 415 2788904
SGTC_548 1436-0017 110 µM 1.5770988807405 0.113749128320365 no 477 0.0573863873619043 454 9677137
SGTC_1011 4112-3381 17.4 µM 1.57568710191924 0.113956948440981 no 478 0.0575489656928445 385 2877139
SGTC_1854 st056233 32.9 µM 1.57430361644694 0.114160865965467 no 479 0.0577086370512089 351 5393174
SGTC_2266 7929956 200 µM 1.5714819965178 0.114577561192195 no 480 0.0580353665172104 404 2967153
SGTC_2194 5927483 104.545 µM 1.56965044607974 0.114848622238749 no 481 0.0582482277927758 415 760979
SGTC_2905 7799065 20.05 µM 1.56652618512201 0.115312050656554 no 482 0.0586127416683179 335 1296806
SGTC_2139 5578692 56.4705 µM 1.56516688705381 0.11551409268551 no 483 0.0587718917410051 330 650991 YMR113W FOL3
SGTC_3038 9091290 49.47 µM 1.56331090028566 0.115790367045893 no 484 0.0589897428406609 383 25236843
SGTC_2378 9074213 121.43 µM 1.55890021767876 0.116448804462296 no 485 0.0595099994092957 419 657714
SGTC_661 1304-0007 33.6 µM 1.55843386372063 0.116518577857163 no 486 0.0595652171847466 366 3117130
SGTC_2081 5214970 32.255 µM 1.55598098937131 0.11688605197535 no 487 0.0598563065039844 372 2063512
SGTC_318 1488-0629 67.2 µM 1.55268041693962 0.117381818087363 no 488 0.0602497515243928 356 3662576
SGTC_1384 3089-0840 101 µM 1.55151290644842 0.11755754130814 no 489 0.0603894083962282 351 1069836
SGTC_2541 muurolladie-3-one 83.07 µM 1.54996324109115 0.117791070585778 no 490 0.060575169527651 390 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2103 5378138 10 µM 1.54917562999833 0.117909886630543 no 491 0.0606697530441065 432 244142
SGTC_3010 9080089 71.4286 µM 1.54910296696582 0.117920852572842 no 492 0.0606784849000898 367 17027233
SGTC_1134 3477-0009 42.5 µM 1.54779228464794 0.118118778105654 no 493 0.0608361573336816 442 3973534
SGTC_1755 st041960 45.185 µM 1.54739141861863 0.118179359591009 no 494 0.0608844446288718 382 2257073
SGTC_1798 st045719 60.953 µM 1.54117540145411 0.119121577550985 no 495 0.0616370512865824 336 3980186
SGTC_985 1493-0307 8.71 µM 1.54050096082456 0.119224126643128 no 496 0.0617191443885437 333 3278274
SGTC_1156 4092-0367 4.88 µM 1.53922212836059 0.119418744925874 no 497 0.0618750385890233 423 1357585
SGTC_544 k015-0020 52.4 µM 1.5384711608615 0.119533134833806 no 498 0.0619667273102359 365 3008304
SGTC_1715 st032160 10.2275 µM 1.53588305650122 0.119927955802792 no 499 0.0622835322000821 392 5289825
SGTC_3331 9141060 1.957 µM 1.53558904057437 0.119972866657121 no 500 0.0623196018866434 382 4906567 YPR165W RHO1
SGTC_534 k292-0788 63.4 µM 1.53020821466935 0.12079688079876 no 501 0.0629825993400615 449 4146317
SGTC_1726 st035556 14.5795 µM 1.52552795267729 0.121516843828822 no 502 0.0635637334827853 450 5919439
SGTC_174 3553-0389 74.3 µM 1.51923210883383 0.122490081267564 no 503 0.0643520409111011 365 738071
SGTC_2353 9059630 146.67 µM 1.5156875248991 0.123040417937067 no 504 0.0647991917863306 372 4779114
SGTC_2594 a-mangostin 100 µM 1.51448266849142 0.12322787962009 no 505 0.0649517331497961 449 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_375 3970-0961 9.27 µM 1.51264712423775 0.123513853580672 no 506 0.0651846586388097 427 2898222
SGTC_2030 5175110 200 µM 1.50455501198163 0.124780128169617 no 507 0.0662192599524104 396 2831986
SGTC_835 0312-0010 67.2 µM 1.50374447724791 0.124907460776757 no 508 0.0663235861461764 382 1626196
SGTC_157 1348-1695 65.819 µM 1.5034090924146 0.124960175285047 no 509 0.0663667916775201 508 5380510
SGTC_3066 9117245 49.47 µM 1.5025721799665 0.125091785761362 no 510 0.0664747009214968 428 17176980
SGTC_2259 7964009 200 µM 1.49641120478169 0.126063622921342 no 511 0.0672732657297102 385 313134
SGTC_1078 idebenone 36.1 µM 1.49629055428593 0.126082706832215 no 512 0.0672889777554729 486 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_362 0310-0100 9.03 µM 1.49619807213556 0.126097336574245 no 513 0.0673010234055078 451 790235
SGTC_471 1-acyl-paf 4 µM 1.49204831357157 0.126755004648422 no 514 0.0678432401003592 413 16759367
SGTC_1875 nocodazole 6 µM 1.49124449068132 0.126882672906258 no 515 0.0679486583707488 414 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2892 9047358 58.44 µM 1.48993495889356 0.127090852717991 no 516 0.0681206692332104 358 6466771
SGTC_421 streptovitacin 30 mM 1.48934591675723 0.127184571801214 no 517 0.0681981511740108 467 91467 include heat shock
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.48921940351929 0.127204706861024 no 518 0.0682148014534123 363 17037758
SGTC_2760 etidronate 98.04 µM 1.48435401932737 0.127980734244145 no 519 0.0688575131557125 439 3305 A chelator and antioxidant.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.48419244857502 0.128006561037439 no 520 0.0688789362838686 524 368090
SGTC_536 3852-0578 10.6 µM 1.48098289925324 0.128520352167296 no 521 0.0693055652414503 409 2869208
SGTC_166 k072-0058 166.424 µM 1.47982144223063 0.12870663277612 no 522 0.0694604523918939 435 5846229
SGTC_2642 cholecalciferol 100 µM 1.47601234634566 0.129318869967356 no 523 0.0699702889239427 401 9821465 A vitamin D precursor, similar to steriods.
SGTC_1480 1070-0044 41.2 µM 1.47581683334263 0.129350349201967 no 524 0.0699965352604925 430 3124987
SGTC_1753 st043925 64 µM 1.47432765556515 0.12959029359296 no 525 0.0701966962382715 455 670181
SGTC_2872 9044037 25.97 µM 1.47368732979417 0.129693561081629 no 526 0.0702828979044412 342 6465195
SGTC_680 0417-1641 114 µM 1.46751781502483 0.130691459732153 no 527 0.0711176233123886 402 2835990
SGTC_1149 3909-7961 23.3 µM 1.4638532949874 0.131286690194906 no 528 0.0716170184710684 433 735261
SGTC_663 1486-0733 13.9 µM 1.46120722707925 0.131717655039515 no 529 0.0719792901503742 502 722445 YPR165W RHO1
SGTC_42 0133-0086 60.653 µM 1.45422820646265 0.132859006556496 no 530 0.072941523657396 409 162923 Model of phenazepam hydroxylation.
SGTC_89 0302-0250 142.109 µM 1.45123281395359 0.133350956712259 no 531 0.0733575212490798 486 4203518 YLR208W SEC13
SGTC_2299 7976368 114.88 µM 1.44626114381581 0.134170245286625 no 532 0.0740519848848754 433 2979718
SGTC_3109 9122853 49.47 µM 1.4455583457651 0.134286338711612 no 533 0.0741505584946958 453 1234709
SGTC_2120 5538279 151.968 µM 1.44341495629852 0.134640825721677 no 534 0.0744518067069 443 2058197
SGTC_2886 9058944 51.95 µM 1.44295220758989 0.134717442184541 no 535 0.074516967386388 261 4949929
SGTC_370 0180-0345 38.7 µM 1.4414574093612 0.13496513759699 no 536 0.0747277507145602 405 3989527
SGTC_3262 9137218 49.47 µM 1.43574149375526 0.135915172862196 no 537 0.0755379566901691 282 17650664
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.43292991180052 0.136384158552791 no 538 0.0759389340386182 471 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1641 st009299 47.1 µM 1.43212081464074 0.136519324826249 no 539 0.0760546242521557 379 4046054
SGTC_287 k060-0039 29.6 µM 1.43154242205634 0.13661600616 no 540 0.0761374089668877 437 5861974
SGTC_3244 9134489 49.47 µM 1.42846745195039 0.137130789464242 no 541 0.0765786782361858 462 16584271
SGTC_790 1575-0012 79.1 µM 1.42459211648718 0.137781447848708 no 542 0.0771375701013052 474 378741 YLR208W SEC13
SGTC_1328 1441-0025 69.2 µM 1.42327482295555 0.138003096830413 no 543 0.0773282512842043 415 4562601
SGTC_2912 7964298 10.93 µM 1.42305015866002 0.13804092330673 no 544 0.0773608076526106 536 2975850
SGTC_2417 cerulenin 830 nM 1.42278013501567 0.138086396241872 no 545 0.0773999508730737 418 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.42257272396683 0.138121331930935 no 546 0.0774300278479446 513 5379071
SGTC_1217 1183-1422 255 µM 1.41892268363381 0.138737120052534 no 547 0.077960779126704 472 2849664
SGTC_3198 9112019 49.47 µM 1.41502589153218 0.139396597894243 no 548 0.0785304524014111 456 45595555
SGTC_2740 felodipine 17.08 µM 1.41305553578959 0.13973086364805 no 549 0.0788196977959755 383 3333 L-type calcium channel blocker
SGTC_2939 9044578 71.43 µM 1.41264896921493 0.139799904382424 no 550 0.0788794815182318 454 2653634
SGTC_948 3448-0295 75.3 µM 1.40966894481591 0.140306662382608 no 551 0.0793187293538903 530 678569
SGTC_2750 bromebric acid 70.15 µM 1.40546592696122 0.141023510583992 no 552 0.0799413872402209 545 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2595 hexamethylquercetagetin 100 µM 1.39988558199126 0.141979101845539 no 553 0.0807737921243874 458 386331
SGTC_666 0272-0154 136 µM 1.39732520085433 0.142419011209667 no 554 0.0811579004518211 515 6870312
SGTC_2763 lisinopril 49.32 µM 1.39613512443165 0.142623796561543 no 555 0.0813369042015934 430 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1307 1187-1599 12.2 µM 1.39257107554371 0.14323827969724 no 556 0.0818747673670268 476 1538471
SGTC_1142 3253-1408 9.78 µM 1.39172092097782 0.143385119890554 no 557 0.0820034622597191 466 256655
SGTC_1256 0570-0116 285 µM 1.38834834102183 0.143968638971882 no 558 0.0825154993513089 460 410638
SGTC_3226 9131256 49.47 µM 1.38643996119171 0.144299532783393 no 559 0.0828063006601447 335 17178073
SGTC_2310 7668677 200 µM 1.38628408079868 0.144326583499223 no 560 0.0828300879320306 480 2197143
SGTC_3250 9135583 49.47 µM 1.38612584098361 0.144354047153234 no 561 0.0828542405087337 453 7699353
SGTC_1243 0416-0003 5.65 µM 1.38416925634267 0.144693917461883 no 562 0.0831533173246042 497 2141977
SGTC_1607 st000305 50.6 µM 1.3837557618629 0.144765812826722 no 563 0.0832166264528211 499 5457690
SGTC_115 0527-0192 112.043 µM 1.38342817327514 0.144822788586941 no 564 0.0832668084640277 588 4233931
SGTC_670 4204-0025 119 µM 1.38135485506085 0.145183740103706 no 565 0.0835849397306226 521 719039
SGTC_546 peri-Naphthalide 147 µM 1.37877196845535 0.145634250399818 no 566 0.0839825360031576 497 223824 A penicillin ester.
SGTC_1061 3448-9325 110 µM 1.378646524463 0.145656154404151 no 567 0.0840018823045194 455 723482
SGTC_1903 st060211 78.3 µM 1.37573367900231 0.146165394520467 no 568 0.0844520504635003 503 688960
SGTC_1191 1487-1166 10.6 µM 1.37292718168203 0.146657172101486 no 569 0.0848874927095165 581 3955771
SGTC_1100 amiodarone 5.07 µM 1.37203970454194 0.146812913956734 no 570 0.0850255389711712 531 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_931 2812-0076 566 µM 1.36939298964609 0.147278040099727 no 571 0.0854382322122258 516 3450959
SGTC_858 0438-0351 2.77 µM 1.36587082244041 0.147898545924176 no 572 0.0859897561066884 524 2799119
SGTC_1864 st057645 30.4 µM 1.36188877124147 0.148602175196611 no 573 0.0866164951951204 457 688666
SGTC_2100 5377183 190 µM 1.36070580336268 0.148811636350919 no 574 0.0868033399483862 542 2844202
SGTC_186 3455-3465 67.277 µM 1.35903035841527 0.149108634985713 no 575 0.0870684844633007 381 755278
SGTC_272 doxorubicin 8.13 µM 1.35202472724776 0.150354778193229 no 576 0.0881837025707165 572 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2077 5212015 200 µM 1.35136325563861 0.150472796523033 no 577 0.0882895491015167 497 780900
SGTC_3289 9119912 71.43 µM 1.34989978501864 0.150734125026891 no 578 0.0885240653368318 497 17014829
SGTC_3133 9127736 49.47 µM 1.34986041516651 0.150741159380301 no 579 0.0885303806268084 515 27243420
SGTC_2425 5628681 7.85 µM 1.34912340760595 0.150872883522736 no 580 0.0886486654446463 604 5714958
SGTC_1952 st077036 64.1 µM 1.34676030490217 0.151295753523279 no 581 0.0890287215062985 530 2937007
SGTC_2323 6148992 148.28 µM 1.34571078007969 0.151483815345056 no 582 0.0891979042115038 456 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2788 5282734 71.43 µM 1.34208921380386 0.152133948105944 no 583 0.0897835353825857 587 743706
SGTC_1770 st043884 66.3 µM 1.33993150014256 0.152522173942501 no 584 0.090133807973608 515 670149
SGTC_549 1661-1316 519 µM 1.33885753784464 0.152715651028619 no 585 0.0903085276492827 525 2857282
SGTC_2790 5423970 71.43 µM 1.33654360243116 0.153133065489093 no 586 0.0906858293865402 568 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_228 caffeine 993.056 µM 1.33617136885638 0.15320028382852 no 587 0.0907466334945735 467 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.33596531455714 0.15323750174201 no 588 0.0907803053347154 438 4620898
SGTC_773 4358-1457 44.6 µM 1.33575539209972 0.153275424490002 no 589 0.090814618813298 582 1186886
SGTC_323 4013-0906 34.3 µM 1.33528172476272 0.153361015915739 no 590 0.0908920788245061 503 2910086
SGTC_2445 5742597 35.57 µM 1.3342896283963 0.153540389773874 no 591 0.0910544776740793 501 1774255
SGTC_1023 4482-3888 16 µM 1.33319449248711 0.153738554745716 no 592 0.091233993131206 498 3303168
SGTC_1167 k781-0610 148 µM 1.32913505834631 0.154474586217981 no 593 0.0919017078641997 566 4525169
SGTC_2174 5790901 200 µM 1.32793966423066 0.154691770919092 no 594 0.0920990200089864 509 786020
SGTC_3229 9132204 49.47 µM 1.32621968211933 0.15500461902547 no 595 0.0923834708649842 459 17682924
SGTC_588 3970-1144 52.9 µM 1.32437524933446 0.155340567446135 no 596 0.0926892252031943 563 1888707
SGTC_1391 3442-0225 151 µM 1.32406288637197 0.15539750936121 no 597 0.0927410800938303 465 5227075
SGTC_2723 salbutamol 83.58 µM 1.32172615678341 0.155823918164064 no 598 0.0931296776697287 427 9884233 β2-adrenoceptor agonist
SGTC_630 4356-0227 183 µM 1.3161999254868 0.156835417213395 no 599 0.0940534743613534 509 779312
SGTC_713 1488-1073 324 µM 1.31540621301895 0.156981049177897 no 600 0.0941867092821593 511 3312542
SGTC_1610 st001799 48.1 µM 1.31270477667845 0.157477380594361 no 601 0.0946412237086234 463 621897
SGTC_2079 5212404 121 µM 1.30507926285085 0.15888396476252 no 602 0.095932929601699 522 758462
SGTC_3208 9114115 49.47 µM 1.30308150395609 0.159253823610107 no 603 0.0962734687318773 498 650895
SGTC_3091 9116372 49.47 µM 1.29989980128153 0.159844037307004 no 604 0.0968176566172672 498 17169793
SGTC_2107 5363541 170.161 µM 1.29863508625931 0.160079041986362 no 605 0.0970345954993186 546 244052
SGTC_3005 9076496 71.4286 µM 1.29765021591736 0.160262203338503 no 606 0.0972037790667346 506 21368410
SGTC_79 0052-0007 94.094 µM 1.29298522894985 0.161131634977672 no 607 0.0980080839457175 566 2801472
SGTC_3342 9147791 14.508 µM 1.29084164988922 0.161532172154825 no 608 0.0983792960454575 543 1838168
SGTC_846 0335-0850 148 µM 1.29052166192549 0.161592018949083 no 609 0.0984347978360369 515 6819598
SGTC_1388 3346-4487 254 µM 1.28452797471996 0.162715678468714 no 610 0.099478640899007 603 3345614
SGTC_1331 1472-0049 76.2 µM 1.28417291334735 0.162782402260201 no 611 0.0995407302252366 526 24051409
SGTC_2576 guaiol 23.12 µM 1.28210613436104 0.163171148398106 no 612 0.0999027086797422 604 227829
SGTC_2800 7887935 81.82 µM 1.28210148209732 0.163172024135165 no 613 0.0999035245665107 548 2961002
SGTC_1679 SEC14.276 6.7 µM 1.28077676165607 0.163421512327764 no 614 0.100136044307901 632 1005053 YMR079W SEC14
SGTC_328 k915-0120 63.5 µM 1.28054574641489 0.163465045413151 no 615 0.100176633366267 543 6624543
SGTC_1336 1486-0901 104 µM 1.27559607768698 0.164399582457982 no 616 0.101049170675961 552 5006114
SGTC_852 0418-0143 439 µM 1.27389647237511 0.164721278810604 no 617 0.101350054385413 649 5369229
SGTC_2627 acetyl isogambogic acid 100 µM 1.27367138245854 0.16476391373674 no 618 0.101389951287256 532 6857789 A caspase activator and apoptosis inducer.
SGTC_483 fpl-64176 144 µM 1.27233428903371 0.165017323775902 no 619 0.10162718525367 490 3423
SGTC_5 0352-0601 109.883 µM 1.27217853886078 0.165046858426297 no 620 0.101654845508634 500 762456
SGTC_3120 9124077 49.47 µM 1.27014882917946 0.165432061832075 no 621 0.102015810531621 561 18774327 YGL155W CDC43
SGTC_407 eburnamonine 100 µM 1.26974843300744 0.16550811865218 no 622 0.102087127279653 493 3195
SGTC_412 gemfibrozil 100 µM 1.2687739391698 0.165693322066779 no 623 0.102260851257774 493 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2380 9035439 200 µM 1.26789581668111 0.165860324755246 no 624 0.10241757911342 623 6462575
SGTC_753 1322-0200 289 µM 1.26753086259548 0.165929764280112 no 625 0.102482767704311 570 5403907
SGTC_1280 0880-0253 10.1 µM 1.26222252271754 0.16694190156999 no 626 0.103434363225688 587 6836607
SGTC_2624 nerol 100 µM 1.25901028597097 0.167556306169823 no 627 0.104013308317277 544 637566 A natural product oil.
SGTC_1557 sumaresinolic acid 42.3 µM 1.25165484377089 0.168968660632309 no 628 0.105347830504166 552 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_564 3555-0129 330 µM 1.24957983069817 0.169368472987093 no 629 0.105726537360112 481 563260
SGTC_2415 st077333 57.7 µM 1.24069671002284 0.171086924405789 no 630 0.107358905068797 684 2766255
SGTC_3171 9103192 49.47 µM 1.23861822050725 0.171490615290955 no 631 0.107743458584668 567 13018434
SGTC_1781 st038725 66.3 µM 1.23801226191605 0.171608421017865 no 632 0.107855757118858 669 4270275 YIL048W NEO1
SGTC_772 k072-0172 35.3 µM 1.23466628695186 0.172259849977977 no 633 0.108477363902259 550 5861980
SGTC_48 0382-0018 55 µM 1.23405408655838 0.172379210005556 no 634 0.108591375321128 556 762596
SGTC_3037 9091026 49.47 µM 1.23203782491645 0.172772691188832 no 635 0.108967477475609 699 25236398 YIL048W NEO1
SGTC_1831 st055328 12 µM 1.2313289676805 0.172911163302354 no 636 0.109099925941061 618 1103068
SGTC_2465 5809242 33.21 µM 1.23024230435794 0.173123575415522 no 637 0.109303191228286 574 2731748
SGTC_1465 k213-0056 144 µM 1.22986343331229 0.173197673105966 no 638 0.109374124694212 579 24048857 YMR208W ERG12
SGTC_2448 5185112 27.17 µM 1.22969426592 0.173230764533567 no 639 0.109405807437901 541 5718189
SGTC_1907 st060210 83.7 µM 1.22827636893661 0.173508282617323 no 640 0.109671619389406 656 688793
SGTC_1794 st048918 76.9 µM 1.22608682203849 0.173937387481195 no 641 0.110083002177638 500 672303
SGTC_2074 5212007 75.395 µM 1.22291479119631 0.174560234216955 no 642 0.11068094065586 516 758611
SGTC_1847 st056231 15 µM 1.22193107250038 0.174753680496959 no 643 0.11086684691297 655 5393180
SGTC_2508 celastrol 40.54 µM 1.2215242027852 0.174833730366119 no 644 0.110943803794431 546 122724 Celastrol is a natural product and antioxidant.
SGTC_2608 thymoquinone 42.66 µM 1.22149070391375 0.174840322162028 no 645 0.11095014160256 550 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_119 0121-0043 24.815 µM 1.21596740801923 0.175929334542654 no 646 0.11199866888575 774 1092378
SGTC_3230 9131665 49.47 µM 1.2158601420906 0.175950526289282 no 647 0.112019101847691 471 15943720
SGTC_898 1000-0849 28.3 µM 1.21438239350798 0.176242638803963 no 648 0.112300867764215 614 6751807
SGTC_1362 1611-0397 101 µM 1.20697849316915 0.177710814748446 no 649 0.113720213330857 613 27816
SGTC_3020 9089140 49.47 µM 1.20640915907732 0.177824030965969 no 650 0.113829883115808 592 17217859
SGTC_1881 5652484 16 µM 1.20628873927039 0.177847983146745 no 651 0.113853089016864 604 2255129
SGTC_2256 7954252 200 µM 1.2052939960808 0.178045921023085 no 652 0.11404491328394 514 2972920
SGTC_2755 lomerizine 42.69 µM 1.20390458051655 0.178322624735174 no 653 0.114313230590731 634 3949 A calcium channel blocker.
SGTC_1673 st016611 27.3 µM 1.20259460754272 0.178583755396523 no 654 0.114566617724288 630 5226799
SGTC_1494 4358-1428 177 µM 1.20255534403723 0.178591585918581 no 655 0.114574218601435 638 1564571
SGTC_2867 9039098 71.43 µM 1.20219660248446 0.178663141597537 no 656 0.114643682675511 624 6463460
SGTC_684 1140-0066 328 µM 1.20110357009514 0.178881272432412 no 657 0.114855514175043 673 6813534
SGTC_220 paclitaxel 373.376 µM 1.20026886380114 0.179047963288129 no 658 0.115017469042922 548 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1144 3486-0183 12.5 µM 1.20024629280606 0.179052472072732 no 659 0.115021850660728 681 6744069
SGTC_709 3807-1509 243 µM 1.1979284554439 0.179515863819307 no 660 0.115472435399094 606 1886677 YPL242C IQG1
SGTC_2581 avocatin a 64 µM 1.19544122691969 0.180013958597759 no 661 0.115957343117103 660 6710728 A skin care supplement.
SGTC_1204 4049-0315 18.3 µM 1.19503913597586 0.180094563124414 no 662 0.116035869936553 615 588402
SGTC_1654 st012436 41.8 µM 1.19315889818545 0.180471782662106 no 663 0.116403574143803 576 4323132
SGTC_3003 9075612 71.4286 µM 1.18847731630822 0.181413168563491 no 664 0.117322705739034 624 6501993
SGTC_692 k241-0027 77.8 µM 1.18828909902142 0.181451080006557 no 665 0.117359765479566 615 3600480
SGTC_741 4582-0002 126 µM 1.18481829758527 0.182151070833518 no 666 0.118044648218631 626 2912688
SGTC_1351 1496-0003 46.5 µM 1.1838066540305 0.182355416266215 no 667 0.11824480381241 644 3891978
SGTC_1706 st031321 9.9705 µM 1.18178865645438 0.182763466312392 no 668 0.118644784949076 640 6103185
SGTC_2086 5274770 176.623 µM 1.1815655851552 0.182808607499184 no 669 0.118689057838212 613 689278
SGTC_171 k064-0041 9.68 µM 1.18036482667177 0.183051715105799 no 670 0.11892757250093 532 53325
SGTC_1878 temozolomide 1 mM 1.18019413921912 0.183086289144528 no 671 0.118961504746539 599 5394 DNA alkylating agent.
SGTC_3178 9107506 49.47 µM 1.17987593129238 0.183150755450574 no 672 0.119024781951495 643 8897194
SGTC_1793 st048256 72.231 µM 1.17780024419447 0.183571619900488 no 673 0.119438125642113 627 672022
SGTC_2011 4012611 177 µM 1.17717354550128 0.183698807127526 no 674 0.119563122631407 641 2049887
SGTC_1812 st052057 4.327 µM 1.17676939049783 0.183780858677577 no 675 0.119643781521374 661 3645418
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.1759368060871 0.183949961912747 no 676 0.119810064791892 610 6708760
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.17419550089568 0.184303945275412 no 677 0.120158363860544 642 229346 A bile salt which induces apoptosis.
SGTC_1461 k072-0203 53.8 µM 1.17013399864167 0.185131238619647 no 678 0.120973524193132 615 5418714
SGTC_49 0717-0965 32.132 µM 1.16679000899472 0.185814109275824 no 679 0.121647591378843 656 5889349 YGL099W LSG1
SGTC_2104 5389443 200 µM 1.16629704762784 0.185914908074943 no 680 0.121747183233071 692 2244536
SGTC_285 1486-1325 46 µM 1.16366252322749 0.186454179888324 no 681 0.122280401353124 683 22310230
SGTC_391 gliotoxin 8.33 µM 1.16287483704372 0.186615602622934 no 682 0.122440144026863 687 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2044 5102272 200 µM 1.15885537540549 0.187440668820029 no 683 0.123257570579752 601 592666
SGTC_2741 miltefosine 3.04 µM 1.1572806165635 0.187764529914037 no 684 0.123578865091224 543 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3194 9111903 49.47 µM 1.15723825831551 0.187773245979418 no 685 0.123587515442447 637 17087251
SGTC_1863 st057641 20.1 µM 1.15533084450808 0.188165993865261 no 686 0.123977484779059 708 3921635
SGTC_1832 st054113 55 µM 1.15464926257069 0.188306458503418 no 687 0.124117042311647 626 1251267
SGTC_2682 pyrogallin 40.03 µM 1.1511509298216 0.189028434264085 no 688 0.124835074282229 710 822798 An ATP competetive kinase inhibitor.
SGTC_2178 5812956 200 µM 1.15007798119789 0.189250207504098 no 689 0.125055877200301 632 5403383
SGTC_1727 st034309 9.9045 µM 1.14953349221277 0.189362811965253 no 690 0.125168032281545 745 870305
SGTC_3160 9100216 49.47 µM 1.14840660488523 0.189595991793578 no 691 0.125400374166968 670 17191039
SGTC_1836 st055642 81 µM 1.14260793511212 0.190798665697487 no 692 0.126600704736118 659 8571
SGTC_558 k064-0027 21.3 µM 1.1413499929389 0.191060185959643 no 693 0.126862152884547 674 5088526
SGTC_1455 4262-0120 131 µM 1.13935322612743 0.191475755531356 no 694 0.127277928270651 699 1529587
SGTC_2246 7293507 91.5585 µM 1.13541211491328 0.192297608159625 no 695 0.128101342988625 693 887656
SGTC_1739 st037196 92.5 µM 1.13297569573841 0.192806759972258 no 696 0.128612229931695 729 612214
SGTC_1560 lithocholic acid 53.1 µM 1.13238817449257 0.192929660628022 no 697 0.128735637161275 594 9903 A bile acid which acts as a detergent.
SGTC_1414 3917-0015 5.4 µM 1.12833164348696 0.193779531231484 no 698 0.129589942227603 653 6618702
SGTC_424 splitomicin 100 mM 1.1249069470135 0.194498801995382 no 699 0.130314233923443 644 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2394 5221648 200 µM 1.12255997614148 0.194992660891744 no 700 0.130812210910794 776 788586
SGTC_353 1988-1175 58.3 µM 1.11951097200439 0.195635381801359 no 701 0.131461106356439 631 2788357
SGTC_1282 0886-0010 32.4 µM 1.11788714006364 0.195978204980259 no 702 0.131807599051402 782 2836211 YNL267W PIK1
SGTC_1898 st060199 18.6 µM 1.11366856841104 0.196870531011169 no 703 0.132710699166965 665 688866
SGTC_2145 5634607 200 µM 1.11364037478962 0.196876502881035 no 704 0.132716749081148 621 308662
SGTC_1489 4065-0444 182 µM 1.11309863626226 0.19699127325636 no 705 0.132833034666131 678 2877968
SGTC_2786 7743617 45.45 µM 1.11279181314864 0.197056293430828 no 706 0.132898926158596 605 583674
SGTC_912 3474-0017 2.18 µM 1.11087135064848 0.197463561702318 no 707 0.133311864419046 701 3360550
SGTC_1742 st038235 28.8875 µM 1.10568142552966 0.198566721206052 no 708 0.134432216188533 709 564103 YBR002C RER2
SGTC_274 sirtinol 40.1 µM 1.10203886559077 0.199343191521902 no 709 0.135222387656901 712 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_131 0141-0277 33.849 µM 1.10041197813597 0.199690578595051 no 710 0.135576330948385 705 1547771
SGTC_1286 0929-0070 131 µM 1.09832278853247 0.200137214214337 no 711 0.136031782206346 732 1420408
SGTC_66 0109-0187 42.4 µM 1.09797720183662 0.200211153004277 no 712 0.136107222256433 644 759417
SGTC_719 2810-4230 27.3 µM 1.09647272691815 0.200533228900017 no 713 0.136435976141042 671 721079
SGTC_3274 9138298 49.47 µM 1.0964179367067 0.200544964181067 no 714 0.13644795899557 732 17015756
SGTC_586 0957-0265 8.15 µM 1.09557774538397 0.200724972812251 no 715 0.136631802609144 622 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3172 9105863 49.47 µM 1.09403218740027 0.201056357463555 no 716 0.136970430828658 641 2348785
SGTC_217 ketoconazole 989 nM 1.09211418463949 0.201468054357286 no 717 0.137391457715767 710 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1458 k015-0034 6.33 µM 1.09025253934016 0.201868136931343 no 718 0.137800957704109 674 3598957
SGTC_1109 tnp00067 928.257 nM 1.08960107337857 0.202008254492362 no 719 0.137944455029623 722 676295
SGTC_2989 9073649 71.4286 µM 1.08838443972923 0.202270084357773 no 720 0.13821271374919 797 21367202
SGTC_924 2046-0044 21.3 µM 1.08723477824607 0.202517687692543 no 721 0.138466532242865 721 3623589
SGTC_2219 9098279 200 µM 1.08299301938672 0.203432804407427 no 722 0.139405760749516 709 902349
SGTC_2069 5228469 200 µM 1.08169992411009 0.203712266578995 no 723 0.139692943449587 684 2835210
SGTC_867 0518-0118 155 µM 1.08157527306582 0.203739218100535 no 724 0.139720648361063 734 6848158
SGTC_1562 morin hydrate 59.1 µM 1.08114293015094 0.203832713928532 no 725 0.139816769741524 696 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1916 st067606 49.2 µM 1.07997766063173 0.204084835286686 no 726 0.140076064087277 764 19590279
SGTC_45 0kpi-0036 14.9 µM 1.07633127354541 0.204874978287362 no 727 0.140889563452472 675 2795021
SGTC_3015 9080845 49.47 µM 1.07588085230404 0.204972707046295 no 728 0.140990273198278 771 5296973
SGTC_2398 5228213 48.84 µM 1.07277923069865 0.20564642396249 no 729 0.141685090795986 820 80771 YMR134W ERG29
SGTC_2591 skatole 100 µM 1.07078744804975 0.206079760075226 no 730 0.142132506007503 719 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3220 9131269 49.47 µM 1.06864392589773 0.206546713307091 no 731 0.142615073740133 733 17722206
SGTC_223 busulfan 5 mM 1.065498468479 0.207233065484438 no 732 0.143325209139885 647 2478 A DNA alkylator.
SGTC_1722 st034304 3.6505 µM 1.0648126629461 0.207382890072124 no 733 0.143480356812149 743 4036148 YLR033W RSC58
SGTC_1178 0988-0033 191 µM 1.06284518276181 0.207813071098389 no 734 0.143926082809816 750 5392207
SGTC_2275 7947463 200 µM 1.06246945426617 0.207895282399211 no 735 0.144011308931191 698 1225414
SGTC_996 3970-0799 1.8 µM 1.06039689727712 0.208349113403699 no 736 0.144482036577203 922 6615648 YGL040C HEM2
SGTC_2895 9054447 58.44 µM 1.05900878439167 0.208653397127758 no 737 0.144797889568703 717 2697450
SGTC_921 1561-0023 372 µM 1.05405582380796 0.209741252285781 no 738 0.145928679933764 767 24050882
SGTC_2049 5262831 67.185 µM 1.05348834493595 0.209866104415825 no 739 0.146058616604567 742 763417
SGTC_2125 5246583 200 µM 1.05215464025775 0.21015970730092 no 740 0.146364303312899 851 835267
SGTC_751 0833-0568 350 µM 1.0494995205008 0.210744925367578 no 741 0.146974137904961 744 6954252
SGTC_81 0411-0046 9.971 µM 1.04866205731349 0.210929709727845 no 742 0.147166841556809 689 12925265
SGTC_712 r015-0009 80.6 µM 1.045979965885 0.211522146088612 no 743 0.147785141075479 698 6813872 YLR060W FRS1
SGTC_1504 k297-0033 30 µM 1.04397131671719 0.211966465852024 no 744 0.14824933024223 627 4388117
SGTC_1779 st039427 55 µM 1.04250758467307 0.212290591735831 no 745 0.148588205424856 846 1124498
SGTC_389 tpck 16.7 µM 1.03890783101132 0.213088945058195 no 746 0.149423802007424 757 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1431 4049-0260 9.09 µM 1.03823447300477 0.213238476598709 no 747 0.149580453507579 781 3854841
SGTC_901 1112-0062 60.1 µM 1.0374859046738 0.213404781777935 no 748 0.149754730696777 739 1908457
SGTC_277 nystatin 15.5 µM 1.03613129139999 0.213705920645366 no 749 0.150070447848681 774 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1376 2910-0861 41.3 µM 1.03180331372815 0.214669713949789 no 750 0.151082133308259 801 1112859
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.02679086031398 0.215789083243269 no 751 0.152259476986798 836 1377
SGTC_1737 st035557 69.7 µM 1.0253975063377 0.216100843647119 no 752 0.152587832166286 651 5716916
SGTC_2345 9052315 157.45 µM 1.0225780714485 0.216732484420955 no 753 0.153253691033452 743 6469265
SGTC_2860 9025725 38.96 µM 1.02209371879404 0.216841101784686 no 754 0.15336827288088 732 40546248
SGTC_207 4185-0010 4.486 µM 1.02188202424512 0.216888584728872 no 755 0.153418370640597 874 3761753
SGTC_2324 6149169 200 µM 1.02142478639587 0.216991163378342 no 756 0.153526613493449 742 2888231
SGTC_1302 1159-0335 255 µM 1.02086717959534 0.217116297156317 no 757 0.153658685326389 761 649284
SGTC_2102 5377816 72.7585 µM 1.01983998239764 0.217346921867778 no 758 0.153902178755822 817 1379702
SGTC_2158 5657123 3.6195 µM 1.01925892667418 0.217477442209183 no 759 0.154040028955233 786 2858827
SGTC_2142 5622915 118.518 µM 1.01820662897566 0.217713930978122 no 760 0.154289884909502 750 5322196
SGTC_1703 st026983 48.3 µM 1.01808682720753 0.217740864105852 no 761 0.154318347440814 824 1104023
SGTC_1218 1348-1416 30.7 µM 1.01475969091987 0.218489618880019 no 762 0.155110196348582 763 6787668
SGTC_2669 eugenol 100 µM 1.01249379741204 0.219000394074815 no 763 0.155651005436541 733 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2258 7960471 200 µM 1.01213914006183 0.219080402652091 no 764 0.155735765227163 679 2974708
SGTC_1316 1272-0050 65.9 µM 1.01103690679779 0.219329167150707 no 765 0.155999382926244 775 7340392
SGTC_580 1123-0028 41 µM 1.0102877381484 0.219498340646817 no 766 0.1561787270477 879 1677248 YPR107C YTH1
SGTC_2015 5119600 184 µM 1.01012539251934 0.219535010599433 no 767 0.156217609007696 802 2828786
SGTC_518 1021-0119 62.6 µM 1.00541842951307 0.22059972873416 no 768 0.157347704654092 747 1097762
SGTC_2393 9031399 185.94 µM 1.00523434074956 0.220641429759039 no 769 0.157392011488828 798 1526623 YDL150W RPC53
SGTC_2152 5568786 200 µM 1.00493605635797 0.220709008731191 no 770 0.157463820552587 781 5399883
SGTC_2408 sulbentine 18.36 µM 1.00371613634502 0.220985515777529 no 771 0.157757728491646 782 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3191 9110352 49.47 µM 1.00325757092457 0.221089505458162 no 772 0.157868301001033 769 17122424
SGTC_1626 st003712 1.76 µM 1.00016511070346 0.221791518799913 no 773 0.158615305273163 737 24207035
SGTC_2078 5212016 200 µM 1.00012683183014 0.221800216382765 no 774 0.158624566287835 777 1899708
SGTC_2780 5215298 71.43 µM 0.999753034798984 0.221885159390207 no 775 0.158715019659194 851 2834131
SGTC_396 dithiazanine 1.25 µM 0.999067576237378 0.222040973767675 no 776 0.158880978371219 756 10578 An antihelmenthic.
SGTC_2747 doxorubicin 7.63 µM 0.998514683030293 0.222166699674103 no 777 0.159014924068513 621 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2195 6536160 144.242 µM 0.996152090000283 0.222704402261034 no 778 0.159588126856592 724 3834386
SGTC_3310 9130229 44.1445 µM 0.993339324439126 0.223345525749563 no 779 0.160272309850041 786 7761258
SGTC_2714 st079313 56.9 µM 0.992371599769555 0.223566345214907 no 780 0.160508143833245 794 2939799
SGTC_3019 9081971 49.47 µM 0.991268264141946 0.223818260378176 no 781 0.160777302578435 861 16451803
SGTC_1245 0418-0076 17.2 µM 0.991142532562558 0.223846977828624 no 782 0.160807993494225 813 6790114
SGTC_583 1488-1091 88.9 µM 0.984445181252814 0.225379695672229 no 783 0.162448336206502 971 4303273
SGTC_1240 0356-0016 42.1 µM 0.983518911888614 0.225592143168028 no 784 0.162676056072147 797 4305613
SGTC_3061 glucosamine 200 µM 0.980771523349082 0.22622294542652 no 785 0.163352712031019 804 91431 and experimental redox chemotherapeutic
SGTC_2040 5100729 123 µM 0.979276055699343 0.226566724241539 no 786 0.163721799033449 830 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1677 st019204 53.9 µM 0.978860258011125 0.226662360383812 no 787 0.163824515563034 764 3945625
SGTC_1073 triclabendazole 3.09 µM 0.978408006899 0.226766406910256 no 788 0.163936284834162 873 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2181 6316240 54.2555 µM 0.977273445336589 0.227027546814281 no 789 0.16421689791621 762 12779990
SGTC_2936 9038235 15.59 µM 0.973391845194952 0.227922248696977 no 790 0.165179295165987 794 4749415
SGTC_385 1494-0393 12.4 µM 0.973001825991205 0.228012256967718 no 791 0.16527619728671 854 3090647
SGTC_1943 st076331 65.2 µM 0.972957508312981 0.228022485825276 no 792 0.165287210551153 856 24208415
SGTC_1259 0671-0132 43 µM 0.972217823356018 0.228193248843633 no 793 0.16547109773594 797 X1259
SGTC_2964 9083345 53.42 µM 0.972032009329186 0.228236157002626 no 794 0.165517312270894 770 17741579
SGTC_3312 9133330 71.43 µM 0.971896284263445 0.228267501489239 no 795 0.16555107425975 886 17617324
SGTC_2433 5607874 27.82 µM 0.966219335463147 0.229580707116708 no 796 0.166967219797524 823 2252428
SGTC_2189 6047310 154.431 µM 0.963385945638514 0.230237713854373 no 797 0.167676938336722 797 711535
SGTC_2291 7917025 104.35 µM 0.962862336894664 0.230359243327801 no 798 0.167808306283966 806 2964612
SGTC_35 0133-0054 64.071 µM 0.961807982642261 0.230604067509856 no 799 0.168073033721478 788 99677
SGTC_2546 rhodinyl acetate 100 µM 0.961126845743814 0.230762306788326 no 800 0.168244196492765 877 6708682
SGTC_395 anisomycin 6.25 µM 0.956735219825283 0.231784008387349 no 801 0.169350458273493 781 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.955889094596076 0.23198114660565 no 802 0.169564134597833 896 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2715 st079500 56.4 µM 0.95502299715821 0.232183034794495 no 803 0.169783033667255 795 28246688
SGTC_2801 7907800 81.82 µM 0.954309013268789 0.232349538664485 no 804 0.169963623487377 847 6620925
SGTC_3052 9092717 49.47 µM 0.952801612245626 0.232701288610323 no 805 0.170345298640042 815 25237534
SGTC_1971 st069429 63.5 µM 0.952058213198883 0.232874868661372 no 806 0.170533729862159 859 1246522 YGL099W LSG1
SGTC_1009 4106-0057 9.87 µM 0.951979064153398 0.232893353813376 no 807 0.170553799827768 915 2928005
SGTC_3185 9108267 49.47 µM 0.950637156824281 0.233206878476415 no 808 0.170894299839473 843 4910486
SGTC_87 0100-0052 35.5 µM 0.950029777996235 0.233348864096259 no 809 0.171048561045864 1039 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_828 2074-0507 139 µM 0.949065478537425 0.233574384766647 no 810 0.171293655337935 873 X828
SGTC_469 w7 172 µM 0.947019589783834 0.234053256673727 no 811 0.171814398369364 842 45115570 A P450 inhibitor.
SGTC_1025 k007-0731 70 µM 0.945369858921464 0.234439797381434 no 812 0.172235042283697 844 6256118
SGTC_1653 st012112 65 µM 0.943202561376033 0.234948143085348 no 813 0.172788651760081 816 720429
SGTC_1967 st070177 51.4 µM 0.942544575918194 0.235102595856797 no 814 0.172956950230393 841 5729214
SGTC_2610 ononetin 44.17 µM 0.940866703055381 0.235496706488964 no 815 0.173386586435025 854 259632
SGTC_77 0828-0286 12.516 µM 0.940125853609006 0.235670838387331 no 816 0.173576504409897 858 745345
SGTC_754 3474-0146 171 µM 0.939325858209481 0.235858951878491 no 817 0.173781733136893 789 24762078
SGTC_734 2023-0417 80 µM 0.937945720934241 0.236183676284099 no 818 0.174136152598915 853 3935732
SGTC_2689 tacrolimus 100 µM 0.937331226481861 0.236328336268323 no 819 0.174294102580761 826 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3344 9148862 3.898 µM 0.937292869320188 0.236337367660227 no 820 0.174303964943658 892 4905352
SGTC_854 0422-0053 192 µM 0.937224799331884 0.23635339555851 no 821 0.174321467917865 866 3596728
SGTC_552 k242-0005 476 µM 0.937035061544843 0.236398074763501 no 822 0.174370261474313 844 4088318
SGTC_1278 0874-0585 172 µM 0.936431171033931 0.236540309051294 no 823 0.17452561757529 865 766306
SGTC_1369 1866-0067 208 µM 0.934946738911267 0.236890137307768 no 824 0.174907874176593 919 3531355
SGTC_1955 wogonin 32.4 µM 0.932281119226508 0.237519043148288 no 825 0.175595631316434 871 5281703 A flavanone.
SGTC_1471 k673-0312 37 µM 0.932160729819343 0.237547468513365 no 826 0.175626733408606 890 24099884
SGTC_1660 st012960 28.1 µM 0.931725392155578 0.237650272473041 no 827 0.175739230177445 843 24207266
SGTC_1456 k015-0012 13 µM 0.931397082088442 0.237727818262702 no 828 0.175824099847424 944 2989616
SGTC_3030 9087619 49.47 µM 0.931122307285911 0.237792729862323 no 829 0.175895150356475 901 25236973
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.931041427619333 0.237811838373292 no 830 0.175916067460467 852 5377381
SGTC_433 pimozide 108 µM 0.931028617700177 0.237814864903187 no 831 0.175919380506987 757 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1448 4255-0083 152 µM 0.929600020541037 0.238152524290767 no 832 0.176289108404637 917 5399660
SGTC_1062 mesoridazine 14.2 µM 0.926269856146944 0.238940651941328 no 833 0.177152878575132 878 4078 A neuroleptic.
SGTC_2245 6637752 200 µM 0.920764573638355 0.240246671990808 no 834 0.178586677260159 809 681890
SGTC_2106 5357045 167.29 µM 0.916709919488456 0.241211040964225 no 835 0.179647333371937 901 668842
SGTC_1505 k297-0037 20.6 µM 0.916281938428715 0.241312955657816 no 836 0.179759519350086 877 4089396
SGTC_378 3970-0959 8.33 µM 0.915518155146112 0.241494892715084 no 837 0.179959837950761 877 6615653
SGTC_715 0868-0130 184 µM 0.913045590648177 0.242084380752072 no 838 0.180609282139422 893 2876258
SGTC_1244 0416-0015 52.5 µM 0.910855146461733 0.242607259143997 no 839 0.181185850737307 880 96201
SGTC_2764 methyldopa 94.69 µM 0.910537412340354 0.242683155842113 no 840 0.181269580336238 925 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_54 0159-0055 9 µM 0.909403578997511 0.242954097748826 no 841 0.18156856665497 894 3319099
SGTC_2768 sulfasalazine 50.2 µM 0.908920058772205 0.243069689959977 no 842 0.181696162397386 915 5384001 An antioxidant and salicylic acid derivative.
SGTC_1979 st071809 45.3 µM 0.907899752706398 0.243313705834559 no 843 0.181965594146052 917 4976333
SGTC_3292 9120825 59.784 µM 0.907642912131866 0.243375152546193 no 844 0.182033457258918 927 24824900
SGTC_1745 st081495 74 µM 0.905742815064406 0.243829993415355 no 845 0.182535997499541 944 13842402 YBL026W LSM2
SGTC_1249 0481-0015 10.2 µM 0.905622558505058 0.243858795582745 no 846 0.182567832246254 861 4227577
SGTC_724 3910-0327 137 µM 0.904901202199622 0.244031603277753 no 847 0.182758865043071 917 2885483
SGTC_2770 toltrazuril 17.5 µM 0.902667997634427 0.244567006992261 no 848 0.183351063011363 945 68591 Kills coccidiodes.
SGTC_83 0170-0301 39.027 µM 0.901850561784176 0.244763142712521 no 849 0.183568128258579 850 3089716
SGTC_2414 st077232 92.9 µM 0.901538893617376 0.244837946725992 no 850 0.183650932048217 831 729801
SGTC_2356 9061756 188.97 µM 0.900056465178434 0.245193915318723 no 851 0.184045101177411 924 20104043
SGTC_1995 st072814 61.1 µM 0.896358395908505 0.246083127021675 no 852 0.185030689954714 870 5769371
SGTC_2093 5331342 194.4 µM 0.894364682233883 0.246563238079893 no 853 0.185563401260828 937 33839
SGTC_2457 5731572 11.68 µM 0.893487856217326 0.246774547455829 no 854 0.185797986252693 953 2865357
SGTC_1267 0828-0272 9.49 µM 0.893154784362919 0.2468548410126 no 855 0.185887144087237 933 745334
SGTC_2952 9073731 13.78 µM 0.892815445333298 0.246936659774952 no 856 0.185978006821513 962 16457353
SGTC_957 1187-1561 14.1 µM 0.892186548429616 0.247088332821162 no 857 0.186146475489675 913 1538454
SGTC_1695 st026914 34.495 µM 0.891668020168224 0.247213425387498 no 858 0.186285449766405 912 3289191
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.89032910508918 0.247536589071716 no 859 0.186644598698322 978 5106787 A p450 inhibitor.
SGTC_1479 0549-0158 134 µM 0.885976872175079 0.248588611550423 no 860 0.187814995059289 969 5440202
SGTC_2951 9072950 58.06 µM 0.885895441225654 0.248608317726856 no 861 0.187836936463271 1024 16488155
SGTC_2279 7948423 32.93 µM 0.885478081003918 0.24870933138053 no 862 0.187949418173852 920 1247112
SGTC_3273 9137859 49.47 µM 0.885051831613744 0.248812519034969 no 863 0.188064338496494 937 2377234
SGTC_1266 0828-0227 32.9 µM 0.884207724714367 0.249016930054772 no 864 0.188292044578367 900 3913820
SGTC_2173 5763948 167 µM 0.884193568035274 0.249020359032979 no 865 0.188295864930534 950 2867177
SGTC_2130 NSC 7 2.4545 µM 0.882646915919337 0.249395134623123 no 866 0.188713535801214 970 21448
SGTC_512 prima-1 270 µM 0.880667357957879 0.249875246464712 no 867 0.189248944631515 972 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2431 5490079 200 µM 0.880519336237003 0.249911166598341 no 868 0.189289017446376 957 5722345
SGTC_1618 st003135 44.5 µM 0.879789936514452 0.250088208582568 no 869 0.189486558665666 926 1270615
SGTC_1470 k295-0292 231 µM 0.878382314181747 0.250430058706724 no 870 0.189868139422711 967 5045612
SGTC_2292 7671323 168.05 µM 0.876467831814461 0.2508954002266 no 871 0.190387878345053 916 937504
SGTC_2959 9079155 11 µM 0.875531931112277 0.251123050332175 no 872 0.190642272014163 881 16189457
SGTC_765 1319-0117 244 µM 0.874341985515023 0.251412652458196 no 873 0.190966020514525 938 3487746 YGL099W LSG1
SGTC_991 3996-0057 64.7 µM 0.873592036354161 0.251595261419091 no 874 0.191170232318881 898 715343
SGTC_2109 5483026 200 µM 0.873494051398388 0.251619125451933 no 875 0.191196923592902 943 759335
SGTC_155 k072-0202 43.6 µM 0.872632472754415 0.251829012612969 no 876 0.191431717483663 931 5857737
SGTC_372 0155-0182 15.9 µM 0.871592133619496 0.252082570327606 no 877 0.191715461803829 989 771486
SGTC_2334 9017922 200 µM 0.871419845981537 0.252124574302696 no 878 0.191762476748136 960 3163164
SGTC_1885 st057546 99.9 µM 0.869613096957038 0.252565284592506 no 879 0.192255938997655 983 702008
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.86953168806622 0.252585151763561 no 880 0.192278191798573 987 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1853 st056710 91.2 µM 0.869130707956011 0.25268301967829 no 881 0.192387821126012 1010 269167
SGTC_1994 st072947 40.9 µM 0.86897263015222 0.252721607491229 no 882 0.192431050637819 932 5286565 YDL195W SEC31
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.866562971526023 0.253310204693858 no 883 0.193090754668794 869 521171
SGTC_1496 4469-0713 57.4 µM 0.86606853642815 0.253431067328885 no 884 0.193226289120743 933 746691
SGTC_888 0916-0002 6.97 µM 0.865736655693739 0.253512211210827 no 885 0.193317296762959 985 2802138 YIL048W NEO1
SGTC_3346 9158254 43.5805 µM 0.863842018431821 0.253975705832144 no 886 0.193837340964546 934 17639500
SGTC_1439 4092-1168 46 µM 0.863428409279666 0.254076948213002 no 887 0.193950982608665 965 2886240
SGTC_2549 cedrol 20.94 µM 0.863312277423544 0.254105378531387 no 888 0.193982897845135 936 6708665 A sedative which affects the nervous system.
SGTC_1395 3486-0190 4.35 µM 0.860565421993486 0.254778324278873 no 889 0.194738718524979 1000 6748079
SGTC_1958 st076513 41.9 µM 0.860482519412468 0.254798648884731 no 890 0.194761557691919 975 732122 YGL099W LSG1
SGTC_1126 isoteolin 1.0172 µM 0.859719566550941 0.254985736174775 no 891 0.194971823147649 939 133323
SGTC_290 2043-6722 48.1 µM 0.859228985529286 0.255106071829079 no 892 0.195107097356589 954 773758 YLR208W SEC13
SGTC_841 0251-0215 91.2 µM 0.855953129576134 0.25591037420915 no 893 0.19601185273872 997 3888614
SGTC_1006 4099-6547 255 µM 0.855255510989662 0.256081827301214 no 894 0.196204855520199 952 3146833
SGTC_1137 ixabepilone 100 µM 0.854629997502095 0.256235610116822 no 895 0.196378007689362 955 154225 A novel microtubule stabilizer.
SGTC_2983 9022671 12.99 µM 0.849390925486196 0.257525526601699 no 896 0.19783190045708 943 6405161
SGTC_1131 3454-3128 32.3 µM 0.848085420046066 0.257847480380491 no 897 0.198195200391675 1016 710982
SGTC_762 1165-0429 115 µM 0.847702162382829 0.257942036101474 no 898 0.198301930899339 970 5967793
SGTC_350 k064-0020 19.8 µM 0.844302190648554 0.258781649808182 no 899 0.199250281139485 1026 2790705
SGTC_32 0928-0142 34.1 µM 0.843696840457195 0.258931287571934 no 900 0.199419416778468 984 2244242
SGTC_2851 9015922 71.43 µM 0.843406247120029 0.259003135836196 no 901 0.199500639634459 959 2996893
SGTC_2916 7875993 68.79 µM 0.842508157017144 0.259225250871323 no 902 0.199751787892783 966 1299250
SGTC_1146 3579-1023 7 µM 0.840747359102553 0.259661015773456 no 903 0.200244741532929 1036 X1146
SGTC_787 4152-0075 138 µM 0.839625464568477 0.25993886099626 no 904 0.200559208466701 970 9566539
SGTC_381 3461-2219 42.7 µM 0.837055567131793 0.260575891958546 no 905 0.201280667245503 1005 2883159
SGTC_3300 9124615 50.48 µM 0.833437508731342 0.261474103323332 no 906 0.202299013956607 985 24824903
SGTC_321 4534-3890 65.3 µM 0.83250622062293 0.261705559892226 no 907 0.202561634209318 1024 699746
SGTC_1947 st076332 61.6 µM 0.82793983911098 0.262841979540929 no 908 0.203852285744292 1014 24208416
SGTC_2051 5263410 176 µM 0.82673466507909 0.263142327397178 no 909 0.20419373437448 1057 227584
SGTC_2436 5633522 8.09 µM 0.822323130931702 0.264243243108301 no 910 0.205446507711792 1027 5724242
SGTC_904 1141-0088 396 µM 0.820119752662482 0.26479398181096 no 911 0.206073921398931 998 1378119
SGTC_1233 0325-0408 14.2 µM 0.818515965451195 0.26519521821126 no 912 0.206531314716927 1009 12874
SGTC_1113 artemisinin 1.17947 µM 0.817574518453148 0.265430893681547 no 913 0.206800091302316 1049 2240 An anti-malaria and mitochondrial poison.
SGTC_248 streptozotocin 5.23457 mM 0.817099731343654 0.265549788974164 no 914 0.206935718236958 1059 5300 DNA alkylating agent.
SGTC_2657 nystatin 74.44 µM 0.815804773842036 0.265874207052978 no 915 0.207305901230098 1050 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_348 k064-0012 10.7 µM 0.815012481178729 0.266072794455091 no 916 0.207532582898414 968 5066323
SGTC_1748 st037455 53.6035 µM 0.813178049773836 0.266532881082579 no 917 0.208057991222391 998 580690
SGTC_1882 5615643 20 µM 0.81287477351694 0.266608983364598 no 918 0.208144929604973 1001 2253075
SGTC_2614 arthonioic acid 13.39 µM 0.812631216539371 0.266670108011014 no 919 0.208214764140083 1003 6710684
SGTC_2738 aclarubicin 5.55 µM 0.812623333674406 0.266672086464531 no 920 0.20821702460687 929 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1225 1216-0074 20.6 µM 0.811261724195964 0.267013936595096 no 921 0.208607692892035 1010 4241466
SGTC_150 3970-0969 77.2 µM 0.810637960572246 0.267170614610871 no 922 0.20878680521762 1021 6615640
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.809321152918238 0.267501524932544 no 923 0.209165221037373 1070 3256 An antibiotic and ribosome inhibitor.
SGTC_2928 9011484 9.79 µM 0.809194918159699 0.26753325825002 no 924 0.209201518778773 972 2994751
SGTC_3090 9117696 49.47 µM 0.806007495398917 0.268335151800034 no 925 0.210119263639261 1016 7923821
SGTC_2565 isoliquiritigenin 100 µM 0.805594633046839 0.268439108303697 no 926 0.210238310599154 897 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1112 tnp00069 1.16933 µM 0.804666008254805 0.268673004970361 no 927 0.210506219985064 1070 145826
SGTC_164 4100-3994 89.624 µM 0.804502993099715 0.268714074852399 no 928 0.210553270722037 1075 4615967
SGTC_597 k018-0003 82.8 µM 0.804228232156309 0.268783304998792 no 929 0.210632588387331 1116 6786234
SGTC_2088 5278280 127.392 µM 0.803534738583024 0.268958080953396 no 930 0.210832863244932 1054 791502
SGTC_2525 harmine 47.85 µM 0.80338310349406 0.268996304001093 no 931 0.210876669002126 989 5280953 A monoamine oxidase inhibitor
SGTC_397 arbidol 50 µM 0.799200830897072 0.270051613772693 no 932 0.212086985119929 1067 131410 A RNA synthesis inhibitor.
SGTC_3336 9143619 71.43 µM 0.798239668419491 0.270294435597574 no 933 0.212365710751978 1072 45595730
SGTC_1778 st046819 58.9 µM 0.79799215512215 0.270356983413946 no 934 0.212437521292468 1128 671715
SGTC_2046 4110841 106 µM 0.797096408064577 0.270583403513313 no 935 0.212697521150603 1055 44119630 YMR134W ERG29
SGTC_3324 9138759 60.749 µM 0.796111412523628 0.270832492459895 no 936 0.212983640683667 1042 45595710
SGTC_2653 dihydrofissinolide 100 µM 0.795337460751712 0.271028292218841 no 937 0.213208614118893 1067 6857746
SGTC_1393 3470-5649 58.2 µM 0.793325497435805 0.271537622983025 no 938 0.21379410256743 953 4108395
SGTC_2852 9023854 51.95 µM 0.791189841296353 0.272078787777359 no 939 0.214416609330357 1052 19798528
SGTC_1396 3511-0007 98.6 µM 0.791018872967012 0.272122133484959 no 940 0.214466489161983 976 X1396
SGTC_1279 0874-0590 65.2 µM 0.788590510911043 0.272738168050052 no 941 0.215175689397773 1056 3523074
SGTC_2799 7812892 81.82 µM 0.784138502540784 0.273869361768685 no 942 0.216479422669591 1059 20205235
SGTC_2704 st078022 71.1 µM 0.783870714902766 0.273937476789629 no 943 0.216557987497981 1067 54697681
SGTC_1796 st049173 110.4 µM 0.779461734364199 0.275060156715663 no 944 0.21785388512161 1036 94134
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.778278741515151 0.275361773035565 no 945 0.218202352576396 1061 4330530
SGTC_877 0771-0151 33.1 µM 0.776566740234224 0.275798553541558 no 946 0.218707215353767 1075 6166523
SGTC_2346 9031566 143.75 µM 0.775965309655421 0.275952076458463 no 947 0.218884734435411 1057 4771086
SGTC_1640 st009078 66.4 µM 0.775543148110311 0.276059863706931 no 948 0.219009389719581 1019 690618
SGTC_1772 st048439 82.2 µM 0.775033599537495 0.276189990337711 no 949 0.219159902893331 1055 2927068 YDL195W SEC31
SGTC_1198 1612-1005 86.7 µM 0.772569808098079 0.276819608646418 no 950 0.219888509174109 1117 6998509
SGTC_215 1287-0124 461.5 µM 0.771835992070247 0.277007270046343 no 951 0.220105785764542 1071 5560863
SGTC_1184 1269-1718 139 µM 0.7717199451344 0.277036952846592 no 952 0.220140157534228 1091 5403821
SGTC_2397 5161689 200 µM 0.770987479185044 0.277224340891465 no 953 0.22035717656246 1069 2259942
SGTC_3055 9094636 49.47 µM 0.770141157711479 0.277440933972781 no 954 0.220608081981127 1094 25236176
SGTC_3124 9127567 49.47 µM 0.768732096027691 0.277801728594557 no 955 0.221026183537572 1048 17592030
SGTC_1411 3909-8223 150 µM 0.767267602542919 0.27817695932067 no 956 0.221461213219629 1140 X1411
SGTC_1367 1812-0510 76.9 µM 0.76625347933594 0.278436941483873 no 957 0.221762746462459 1075 1142582 YDR527W RBA50
SGTC_2020 4017018 200 µM 0.765245679940442 0.278695419698605 no 958 0.222062631638948 1110 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2712 st079126 47.7 µM 0.761825428139756 0.279573508484939 no 959 0.223082100907253 1073 3152970
SGTC_1948 st076329 66.6 µM 0.761371240423358 0.279690214042387 no 960 0.223217680116094 1036 24208413
SGTC_2537 larixol 68.93 µM 0.760697328393917 0.27986342229412 no 961 0.22341893545609 1115 6708759
SGTC_2543 pimpinellin 60.67 µM 0.758438597111713 0.280444338448839 no 962 0.224094229479941 1032 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3086 9117350 49.47 µM 0.754785561967221 0.281385084964187 no 963 0.225188829127895 1061 2679265
SGTC_2119 5528445 120.635 µM 0.753273618653522 0.281774892727875 no 964 0.225642754215552 1093 791935
SGTC_2967 9089538 49.85 µM 0.752275075819694 0.282032478708687 no 965 0.22594282664889 1140 728216
SGTC_1469 k284-2957 126 µM 0.751841309115952 0.282144409299767 no 966 0.226073248283009 1131 23884841
SGTC_2909 7941780 10.49 µM 0.751076371710607 0.28234184836359 no 967 0.226303347425226 1121 1243215
SGTC_1301 naphtanilide LB 4.81 µM 0.750227267487272 0.282561089655221 no 968 0.22655891946231 1165 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1743 st037606 46.3785 µM 0.748903662014228 0.282903011750775 no 969 0.226957636486548 1105 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3275 9138069 49.47 µM 0.746810000626986 0.283444264888252 no 970 0.227589129032747 1105 17617007
SGTC_3169 9102970 49.47 µM 0.744446810330918 0.284055792309824 no 971 0.228303104291007 1164 17027839
SGTC_1452 4194-0072 190 µM 0.744398509508829 0.284068297787872 no 972 0.228317710219383 1160 1343545
SGTC_3087 9117406 49.47 µM 0.738254887531842 0.285661074888944 no 973 0.230179787325198 1127 42546093
SGTC_986 1493-0483 84 µM 0.736305595149315 0.286167329162425 no 974 0.230772370962081 1080 40079
SGTC_2957 9076800 11.52 µM 0.735857261933698 0.28628382684978 no 975 0.230908784401366 1076 16459615
SGTC_697 0508-1955 564 µM 0.735555732793953 0.286362190717296 no 976 0.231000555379073 1139 6243113
SGTC_3156 9099931 49.47 µM 0.73525743905486 0.286439723759719 no 977 0.231091361686156 1151 18111053
SGTC_3211 9128781 49.47 µM 0.73332974623548 0.286941013180801 no 978 0.23167866828113 1048 17194361
SGTC_3157 9099274 49.47 µM 0.731154931778431 0.287507064133086 no 979 0.232342262327559 1138 17217662
SGTC_3334 9142812 21.919 µM 0.729566878145688 0.287920728863491 no 980 0.232827487136446 1120 45283678
SGTC_2736 butenafine 14.65 µM 0.727409729741853 0.288483084174966 no 981 0.233487497948226 1141 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_746 1095-0025 46.6 µM 0.72620516334095 0.288797332285719 no 982 0.233856503560742 1161 6749286
SGTC_866 0495-0101 262 µM 0.724379582327221 0.289273898067583 no 983 0.234416365640344 1121 635694
SGTC_2937 9044753 11.33 µM 0.723127094748298 0.289601072114115 no 984 0.234800902213833 1186 6465530 YGL099W LSG1
SGTC_3175 9106517 49.47 µM 0.722737934982518 0.289702763555251 no 985 0.234920452336683 1136 41468073
SGTC_3338 9144300 39.5675 µM 0.722075811021183 0.289875821844197 no 986 0.235123934510717 1138 4901274
SGTC_2601 securinine 100 µM 0.720924345214376 0.290176894061605 no 987 0.235478031651077 1142 442872 A GABA receptor antagonist.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.720132343698645 0.290384062641633 no 988 0.235721757545975 1161 688798
SGTC_1187 1391-0724 117 µM 0.718954913520352 0.290692178042911 no 989 0.236084349986368 1173 6997986
SGTC_352 k048-0007 5.11 µM 0.718114892554461 0.290912092049816 no 990 0.236343224152879 1153 6811911
SGTC_874 0599-0792 117 µM 0.714861187358249 0.291764631559471 no 991 0.237347410997094 1199 765305
SGTC_75 0159-0059 199.013 µM 0.714480569604963 0.291864437464096 no 992 0.237465033436774 1169 5377270
SGTC_571 k831-0106 44.2 µM 0.714193564189544 0.291939706779018 no 993 0.237553747979255 1141 4783639
SGTC_1215 3852-0577 11.2 µM 0.713985376799291 0.29199431113395 no 994 0.237618110930013 1213 2884876
SGTC_2640 pentamidine 10.38 µM 0.712133108159954 0.292480341978999 no 995 0.238191177056019 1193 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1619 st003326 88.7 µM 0.711717335966383 0.29258949125953 no 996 0.23831991516798 1146 2849032
SGTC_2438 5259590 200 µM 0.706805210572393 0.293880461684729 no 997 0.239843768035387 1190 1201127
SGTC_23 0213-0011 39.996 µM 0.705971317155616 0.294099881041016 no 998 0.240102987448821 1184 627608
SGTC_2621 lithochol-11-enic acid 100 µM 0.705038024288532 0.294345544765999 no 999 0.240393286638069 1178 6708711
SGTC_2968 9090663 33.37 µM 0.702800953162009 0.294934777757817 no 1000 0.241089901571133 1141 25236811
SGTC_1220 1838-0075 193 µM 0.702094913106105 0.29512085784601 no 1001 0.241309987241032 1130 5529645
SGTC_210 3551-0445 56.827 µM 0.701453222990505 0.295290025094753 no 1002 0.241510108512069 1208 2865180 YOR207C RET1
SGTC_897 1000-0139 31.4 µM 0.699894328016616 0.295701178676213 no 1003 0.241996649935882 1164 6151020
SGTC_970 1315-0089 19.5 µM 0.697416533007989 0.29635523003935 no 1004 0.242771078921316 1151 6811083 YLR033W RSC58
SGTC_2284 7945075 39.21 µM 0.695367388717604 0.296896633131543 no 1005 0.243412546126569 1267 1245402
SGTC_3110 9122132 49.47 µM 0.69511979171812 0.296962081210561 no 1006 0.243490116228064 1253 918317
SGTC_908 3448-7491 47.7 µM 0.694343010404562 0.297167453034716 no 1007 0.243733562058379 1226 1203031
SGTC_1317 1273-0028 910 nM 0.694170906710608 0.297212964007864 no 1008 0.243787517700721 1176 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2010 4012422 159 µM 0.693708762730633 0.297335188779152 no 1009 0.243932434778662 1170 952393
SGTC_949 1165-0505 146 µM 0.692715095618036 0.29759806499599 no 1010 0.244244181887279 1222 6244267
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.690896304128773 0.298079503754869 no 1011 0.244815354449398 1073 88881 An O-methylated flavonoid and antioxidant.
SGTC_1837 st055472 66.5 µM 0.690743017054321 0.298120095445289 no 1012 0.244863525490404 1257 676091
SGTC_2532 xanthone 78.9 µM 0.689194994008608 0.298530165856866 no 1013 0.245350283325867 1119 7020 An insecticide.
SGTC_676 falcarinol 140 µM 0.68906922821353 0.298563492410388 no 1014 0.245389851746496 1238 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2070 5230947 200 µM 0.688794876725671 0.298636198410977 no 1015 0.245476180080615 1281 2835538
SGTC_980 1473-0395 201 µM 0.686862868408065 0.299148428545327 no 1016 0.246084573914778 1162 768876
SGTC_2184 6075246 200 µM 0.685009008567565 0.299640313868845 no 1017 0.246669118162541 1219 2267320
SGTC_1000 4048-0884 8.67 µM 0.682969921366304 0.300181768415605 no 1018 0.247312924599275 1212 13040088
SGTC_193 1273-0060 1.558 µM 0.682598044621977 0.300280563394979 no 1019 0.247430435011803 1106 2847393 YHR072W ERG7
SGTC_2098 5376439 882.5 nM 0.682583245272823 0.30028449538183 no 1020 0.247435112118428 1255 2844116
SGTC_1043 0916-0009 19.3 µM 0.682541647313159 0.300295547521575 no 1021 0.247448258766672 1256 3101130
SGTC_2904 7225135 42.03 µM 0.678160386164534 0.301460630315527 no 1022 0.248835003248356 1301 4446116
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.67802245654075 0.301497342132258 no 1023 0.248878727419343 1270 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3096 9117468 49.47 µM 0.677965837711512 0.301512412574364 no 1024 0.248896676969198 1132 41316311
SGTC_2713 st079149 53.4 µM 0.676914053467699 0.30179243146622 no 1025 0.249230243481529 1244 3103253
SGTC_2272 7805186 180 µM 0.675382140855273 0.302200484989418 no 1026 0.249716504520168 1203 2956062 YPR165W RHO1
SGTC_962 1254-0300 21.5 µM 0.675238941215935 0.302238641539176 no 1027 0.249761984809875 1189 7340576
SGTC_2853 9015042 58.44 µM 0.672974300711613 0.302842358119445 no 1028 0.250481820364505 1182 6457456
SGTC_592 k241-0073 46.5 µM 0.669849292866744 0.303676320090465 no 1029 0.251476933480798 1248 4230158
SGTC_1088 bifonazole 369 nM 0.669844602894753 0.303677572460041 no 1030 0.251478428502331 1181 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2522 biochanin a 4.94 µM 0.668491447359354 0.304039003653899 no 1031 0.251909969742208 1201 5280373 A possible chelator.
SGTC_3352 9151559 45.5865 µM 0.667203607228413 0.30438316691533 no 1032 0.252321043659469 1208 17159339
SGTC_2090 5301565 104.445 µM 0.666229972121373 0.304643476879128 no 1033 0.252632059052447 1265 2056344
SGTC_2150 5556613 200 µM 0.664604852405831 0.305078187404143 no 1034 0.253151632406775 1256 743190
SGTC_2372 9071633 200 µM 0.663396306298997 0.305401645252169 no 1035 0.253538385466042 1268 21321366
SGTC_633 0437-0093 97.7 µM 0.663271901530963 0.305434949840339 no 1036 0.253578214490631 1251 2831118
SGTC_307 1501-1223 22.3 µM 0.661486623715566 0.305913066518048 no 1037 0.254150145041512 1237 2830329
SGTC_1558 st069300 45.6 µM 0.661192641375373 0.305991829918804 no 1038 0.254244389884464 1210 24208000
SGTC_2819 7996655 46.38 µM 0.660206356900155 0.306256139611575 no 1039 0.254560706720604 1152 6456960
SGTC_1030 k029-0042 36.7 µM 0.66013525529509 0.306275197692356 no 1040 0.254583518080009 1267 6080581
SGTC_3022 9087993 49.47 µM 0.659505441392165 0.306444035950092 no 1041 0.254785626522018 1271 17173644
SGTC_151 3013-0144 2.285 µM 0.659316500057739 0.306494694682615 no 1042 0.254846274519596 1223 906558 YHR107C CDC12
SGTC_740 k014-0057 261 µM 0.657954621060135 0.306859949452826 no 1043 0.255283645457537 1272 4012779
SGTC_2618 avocadyne 43.43 µM 0.657206278031551 0.307060736093499 no 1044 0.25552414468972 1210 3015189
SGTC_2470 5664817 21.68 µM 0.656506651606585 0.30724850401236 no 1045 0.255749094601133 1287 2859561
SGTC_2281 7943571 200 µM 0.656131026597192 0.307349336278276 no 1046 0.25586991142962 1304 1244024
SGTC_2197 6588183 93.1375 µM 0.655459090850069 0.307529746118566 no 1047 0.256086108552643 1232 884136
SGTC_859 0439-0102 54.6 µM 0.655421816361476 0.307539755410109 no 1048 0.256098104507688 1271 610143
SGTC_2514 salinomycin 42.74 µM 0.653792599764361 0.307977387694708 no 1049 0.256622717413392 1302 23682228 A polyether potassium ionophore.
SGTC_550 4123-0385 25.7 µM 0.652339700591931 0.308367888954807 no 1050 0.257091027187097 1259 5731123
SGTC_1608 st001473 40.5 µM 0.652223984307302 0.308398999794891 no 1051 0.257128344860735 1221 7292267
SGTC_3076 9116187 49.47 µM 0.6518149516392 0.308508981082092 no 1052 0.257260277541124 1226 27241210
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.649992777279396 0.308999138607109 no 1053 0.257848443550457 1231 688662
SGTC_579 4491-1009 110 µM 0.6499362956471 0.309014337379203 no 1054 0.257866685977012 1375 1271041
SGTC_1177 0983-0204 23.6 µM 0.646687786644343 0.309889035638441 no 1055 0.258917014593459 1293 766818
SGTC_2626 ethyl orsellinate 100 µM 0.643469063176208 0.310756776557423 no 1056 0.259959891311968 1266 75653 A natural product.
SGTC_1254 0550-0035 264 µM 0.642171807439584 0.311106804046295 no 1057 0.260380818012282 1310 15121435
SGTC_3223 9129970 49.47 µM 0.641486731405982 0.311291721274743 no 1058 0.260603249443501 1338 17248386
SGTC_2644 guaiazulene 100 µM 0.640766908021874 0.311486068900499 no 1059 0.260837068028448 1283 3515 A coloring agent.
SGTC_2940 9060638 45.86 µM 0.638932831023038 0.31198149512967 no 1060 0.261433314480822 1297 4027022
SGTC_2483 5729050 27.16 µM 0.63852939244532 0.312090518830127 no 1061 0.261564563574824 1338 2865180
SGTC_484 loperamide 105 µM 0.636342977371394 0.312681653426543 no 1062 0.262276449323095 1264 3955 An opioid-receptor agonist.
SGTC_1842 st055362 61.2 µM 0.63575005413301 0.312842043502604 no 1063 0.26246967306798 1283 676032
SGTC_464 bw-b 70c 158 µM 0.633837989631903 0.313359512223836 no 1064 0.263093278893358 1318 5353454
SGTC_257 daunorubicin 18.5 µM 0.633686571798279 0.313400506685846 no 1065 0.26314269504255 1335 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_714 4296-0578 26.1 µM 0.633398550598949 0.313478491143215 no 1066 0.26323670563509 1284 1589775
SGTC_1412 3909-8563 178 µM 0.63254404451734 0.313709905784274 no 1067 0.263515718735747 1357 23767530
SGTC_2545 solidagenone 89.61 µM 0.631843298383185 0.313899734362896 no 1068 0.263744638761195 1161 6708572 An anti ulcer agent
SGTC_1353 1498-1206 8.11 µM 0.631428771644138 0.314012050751585 no 1069 0.26388010424879 1322 6756808
SGTC_1514 1189-1591 158 µM 0.631384233274012 0.314024119487908 no 1070 0.26389466129932 1365 767698 YMR146C TIF34
SGTC_3303 9125618 40.5795 µM 0.631071021420592 0.314108997346041 no 1071 0.263997043934013 1342 22695467
SGTC_987 1497-1013 404 µM 0.629778355148474 0.314459403362678 no 1072 0.264419804517766 1288 1676435
SGTC_2911 7942208 15.64 µM 0.627328105676207 0.315124056825001 no 1073 0.265222091885452 1263 1243384
SGTC_2721 ifenprodil 61.44 µM 0.625971099288562 0.315492415584754 no 1074 0.265666948904514 1308 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_939 1165-0479 45.3 µM 0.625935543466572 0.315502069663825 no 1075 0.265678609982152 1251 1377347
SGTC_606 k015-0008 38.6 µM 0.62569593523444 0.31556713112041 no 1076 0.26575719994711 1371 1970475
SGTC_1720 st037298 9.481 µM 0.62523704145037 0.315691751721337 no 1077 0.265907747059367 1299 597396
SGTC_1210 3013-0140 750 nM 0.623359465731318 0.316201858298233 no 1078 0.266524164214967 1347 905973
SGTC_569 4130-2812 160 µM 0.623149850459888 0.31625882907179 no 1079 0.266593026737563 1244 743552
SGTC_541 4513-1321 94 µM 0.622588064483072 0.316411536886252 no 1080 0.266777628255125 1248 747515
SGTC_1354 1498-1681 81 µM 0.621234891899418 0.316779492336802 no 1081 0.267222542543391 1343 5754243
SGTC_2897 9048598 12.99 µM 0.620242406768968 0.317049484751735 no 1082 0.267549103045527 1293 6467404
SGTC_3351 9150312 21.596 µM 0.618812555276945 0.317438628156238 no 1083 0.268019925058379 1309 4904905
SGTC_1467 k284-1082 293 µM 0.615418151394186 0.318363245106664 no 1084 0.269139303589818 1346 3334705
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.615362481967843 0.318378418607549 no 1085 0.269157681326027 1286 5355888
SGTC_82 0054-0107 293.755 µM 0.613156977956607 0.318979805300965 no 1086 0.269886274248715 1323 3104697
SGTC_479 n-linoleoylglycine 10 µM 0.612649016952701 0.319118381388304 no 1087 0.270054220013497 1314 6433346 An anti-infammatory.
SGTC_251 melphalan 456.522 µM 0.612115015258369 0.319264088855955 no 1088 0.270230831901945 1392 460612 A DNA alkylator.
SGTC_16 erodoxin 22.806 µM 0.612075094324586 0.319274982786315 no 1089 0.270244037385065 1343 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_334 1502-1024 68.5 µM 0.608932150200482 0.320133142542142 no 1090 0.271284706464583 1338 3296216
SGTC_177 1327-0068 8.361 µM 0.605277370587629 0.32113226664809 no 1091 0.272497357394382 1323 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2432 5630864 12.22 µM 0.601574311270839 0.32214591146781 no 1092 0.273728766405325 1314 5714970
SGTC_2163 5671233 125 µM 0.598189446349254 0.323073615307723 no 1093 0.274856766263685 1434 701023
SGTC_945 3381-0768 11.3 µM 0.598061519886832 0.323108698278324 no 1094 0.274899442404718 1340 1126236 YIL048W NEO1
SGTC_925 2064-1272 59.6 µM 0.597020855518188 0.323394151915352 no 1095 0.27524672828612 1328 6815817
SGTC_2048 5246248 200 µM 0.596544010505462 0.323524984978256 no 1096 0.275405931003414 1335 677046
SGTC_335 4077-0256 27.6 µM 0.595152223894506 0.323906977408473 no 1097 0.275870861282907 1350 3121989
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.594857352407667 0.323987932234991 no 1098 0.275969413422006 1264 641818 YHR062C RPP1
SGTC_1200 1643-0193 18.4 µM 0.593773769557392 0.324285493525635 no 1099 0.276331717634747 1340 5403974
SGTC_1175 0741-0056 27.6 µM 0.593051479876061 0.324483902930634 no 1100 0.276573350251541 1431 765927
SGTC_3058 9093861 49.47 µM 0.591840982933444 0.324816532173398 no 1101 0.276978538353786 1364 17217477
SGTC_1698 5-fluorocytosine 1.055 µM 0.58990810900212 0.325347951087989 no 1102 0.277626128663845 1386 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2381 9035592 200 µM 0.585248551049136 0.32663049597731 no 1103 0.279190301759989 1299 4749657
SGTC_244 nsc-207895 1.295 µM 0.584731556814613 0.326772925534696 no 1104 0.279364115888364 1274 42640
SGTC_726 3448-4391 34.2 µM 0.584656730624643 0.326793541901173 no 1105 0.279389276904118 1462 1356692
SGTC_2027 5150920 200 µM 0.583505670128541 0.327110752609455 no 1106 0.279776470560922 1358 786715
SGTC_1904 st060225 78 µM 0.580677562573701 0.327890656265767 no 1107 0.280728893290548 1329 66595
SGTC_3207 9114163 49.47 µM 0.579164328831714 0.328308267566477 no 1108 0.281239148720194 1512 849233
SGTC_972 1319-0219 195 µM 0.576499604728652 0.329044180380156 no 1109 0.282138768479135 1331 23903702
SGTC_3247 9135149 49.47 µM 0.571653454528297 0.330384232351804 no 1110 0.283778386821082 1355 8934436 YOR116C RPO31
SGTC_2227 7312221 64.1025 µM 0.57097121212151 0.330573060532963 no 1111 0.284009578603384 1399 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_545 4218-0007 221 µM 0.570181803211054 0.330791603637846 no 1112 0.284277198351996 1362 2840508
SGTC_105 0111-0055 734.78 µM 0.569783058324655 0.330902015692623 no 1113 0.284412423791317 1362 5179370
SGTC_98 0074-0023 107.663 µM 0.569407309959285 0.331006073496713 no 1114 0.284539878592884 1330 3563821
SGTC_2638 epoxomicin 18 µM 0.567733015645751 0.331469902485372 no 1115 0.285108134821016 1419 9915668 A protesome inhibitor.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.567139053585463 0.331634509699711 no 1116 0.285309855724458 1426 5024745
SGTC_2915 7971052 15.16 µM 0.566219657376813 0.331889369969428 no 1117 0.28562223430661 1266 5741558
SGTC_845 0330-0138 4.51 µM 0.565421491308428 0.332110687866806 no 1118 0.28589355504814 1398 9039800
SGTC_2681 menadione 3.18 µM 0.564069251931515 0.332485774537904 no 1119 0.286353501485592 1388 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_910 3454-3003 490 µM 0.563921284651338 0.332526828168773 no 1120 0.28640385192289 1340 820824
SGTC_946 3434-1334 87.4 µM 0.561688051424717 0.333146684089807 no 1121 0.287164288315607 1431 4047976
SGTC_1103 duloxetine 36.1 µM 0.560394643960419 0.333505890779108 no 1122 0.287605142063135 1500 60835 A selective serotonin reuptake inhibitor.
SGTC_509 pifithrin 175 µM 0.560164516108061 0.333569818176674 no 1123 0.28768361390795 1481 4817 A p53 inhibitor.
SGTC_2630 antimycin a 100 µM 0.556982439743929 0.334454264405969 no 1124 0.288769713518602 1354 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1548 st061468 90.8 µM 0.556735537057312 0.334522928591766 no 1125 0.288854066468142 1397 390799
SGTC_880 0833-0487 87.2 µM 0.555654604714201 0.334823603417284 no 1126 0.289223497541652 1363 76075
SGTC_2847 9005661 71.43 µM 0.55422060066047 0.335222652998853 no 1127 0.289713940698488 1333 2991449
SGTC_799 1310-0557 151 µM 0.552539675577492 0.335690651711818 no 1128 0.290289329599617 1421 5354492
SGTC_1208 2323-2347 50.3 µM 0.55052399989112 0.336252186965057 no 1129 0.290980010146521 1423 5412760
SGTC_2121 5257820 149.641 µM 0.550461011051837 0.336269740552088 no 1130 0.291001605928651 1442 791256
SGTC_1650 st011916 45.8 µM 0.549344139955815 0.336581046906265 no 1131 0.291384650516485 1442 242528
SGTC_2458 5808907 16.39 µM 0.549303939013327 0.336592254236523 no 1132 0.291398442306061 1436 2731747
SGTC_1764 st044502 93.5 µM 0.547370850348962 0.337131337195673 no 1133 0.292061988687578 1392 8407
SGTC_1491 4138-0063 26.5 µM 0.546535821837055 0.337364306245279 no 1134 0.292348835506348 1398 23883227
SGTC_1684 st024538 14.6195 µM 0.544780518736547 0.337854230849412 no 1135 0.292952239403326 1417 6732859
SGTC_2821 7996764 71.43 µM 0.543992624591823 0.338074230281495 no 1136 0.293223274094831 1466 2987135
SGTC_2055 5235184 200 µM 0.543448795123538 0.338226113119633 no 1137 0.293410418599981 1433 2836034
SGTC_2220 6782180 200 µM 0.542896853408766 0.338380288500247 no 1138 0.293600411281074 1395 833803
SGTC_284 0988-0104 32.6 µM 0.542094852292398 0.338604361943891 no 1139 0.293876582373168 1441 4666532
SGTC_1355 1499-0035 1.68 µM 0.540745188705238 0.338981577381598 no 1140 0.294341613451988 1408 1548538
SGTC_1662 st014054 52 µM 0.540403732322277 0.339077036122863 no 1141 0.294459317221313 1409 2838777
SGTC_2686 alizarin 95.37 µM 0.538505518822899 0.339607895556895 no 1142 0.29511404803073 1395 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1632 st005650 90 µM 0.535162873662122 0.340543481993896 no 1143 0.296268618187583 1439 2759605
SGTC_813 k007-0158 173 µM 0.534765378922409 0.340654803845281 no 1144 0.296406053019418 1504 6523916
SGTC_1490 4089-0339 670 nM 0.534403603060683 0.34075613438136 no 1145 0.296531163354355 1422 742542
SGTC_429 1112-0049 25.5 µM 0.533571479910615 0.34098924905054 no 1146 0.296819022287801 1385 2836170
SGTC_2811 7967822 32.47 µM 0.531411525010747 0.341594631566921 no 1147 0.297566818388523 1505 2232244
SGTC_806 3966-4455 5.86 µM 0.531399619600163 0.341597969493434 no 1148 0.297570942532565 1374 714982
SGTC_671 0560-0003 407 µM 0.529325137165993 0.342179782205707 no 1149 0.298289960382849 1464 3238678
SGTC_2341 7987486 176.74 µM 0.528914460705452 0.342295005685287 no 1150 0.298432395030962 1533 1258686
SGTC_767 0929-0023 86 µM 0.526428757172485 0.342992732481435 no 1151 0.299295169762851 1462 1204563
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.52593200274534 0.343132233718815 no 1152 0.299467726200346 1370 6708630 An antioxidant.
SGTC_1993 st073995 70.8 µM 0.524486276630232 0.343538351872777 no 1153 0.299970181188276 1472 3098394
SGTC_1659 st012954 42.1 µM 0.524054263961208 0.343659743405382 no 1154 0.300120399059824 1463 24207262
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.523348077769488 0.343858209856737 no 1155 0.300366024782277 1535 551469
SGTC_520 3584-0023 682 µM 0.523307071556853 0.343869735558479 no 1156 0.300380290355596 1424 1340790
SGTC_2 0422-0095 29 µM 0.522241592085073 0.344169262933513 no 1157 0.300751065246907 1332 6790840
SGTC_1058 3448-5425 97.3 µM 0.522118318419967 0.344203923916369 no 1158 0.300793976423428 1379 7279705
SGTC_2781 5567276 71.43 µM 0.522103904614086 0.344207976746419 no 1159 0.30079899400445 1493 2853274
SGTC_1883 5-benzylidenerhodanine 20 µM 0.52189739585943 0.344266044213648 no 1160 0.30087088578447 1505 1273210
SGTC_2602 kawain 100 µM 0.521483150284747 0.344382535531654 no 1161 0.301015120229276 1420 5369129
SGTC_889 0919-1524 82.7 µM 0.519242180814077 0.345012981420704 no 1162 0.301795933876128 1429 3905452
SGTC_3350 9150499 3.57 µM 0.519195092437153 0.345026233290294 no 1163 0.301812350486774 1407 4910996 YPR165W RHO1
SGTC_1305 1181-0477 144 µM 0.517012370321275 0.345640715301201 no 1164 0.302573761750423 1535 6252086
SGTC_1545 lovastatin 49.4 µM 0.51667398969087 0.345736013010898 no 1165 0.302691878012858 1501 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2159 5658611 73.75 µM 0.516125634027798 0.345890466477898 no 1166 0.302883332702191 1459 793844
SGTC_2287 7945887 168.79 µM 0.515477544193184 0.346073044796713 no 1167 0.303109678777499 1487 1245853
SGTC_2160 5660466 132.927 µM 0.514232595221583 0.346423869218454 no 1168 0.303544690669795 1470 2859134
SGTC_3069 9117009 49.47 µM 0.514167990079622 0.346442078432838 no 1169 0.303567272700777 1406 41904981
SGTC_1086 cerivastatin 2.18 µM 0.514099446456386 0.346461398111718 no 1170 0.303591232205562 1474 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_850 0388-0143 75.9 µM 0.513207967796433 0.346712706302744 no 1171 0.303902926498388 1440 67273
SGTC_2946 9065502 71.43 µM 0.512810818161206 0.346824684672899 no 1172 0.304041830806877 1358 16489101
SGTC_3150 9097574 49.47 µM 0.512731823518419 0.34684695921208 no 1173 0.304069462800488 1551 17217476
SGTC_2839 9003951 25.97 µM 0.51263408691735 0.346874519253431 no 1174 0.304103652201231 1469 2990634
SGTC_2496 diffractaic acid 79.83 µM 0.512296458304057 0.346969730950946 no 1175 0.304221771798767 1585 94870 An apoptosis inducer which activates caspases.
SGTC_2655 perillic acid 100 µM 0.51163999776023 0.34715488131115 no 1176 0.304451493437924 1423 5702197 An apoptosis inducer.
SGTC_1795 st049545 62.3 µM 0.509807534521826 0.347671908434285 no 1177 0.305093153299966 1485 5291882
SGTC_961 1252-1571 372 µM 0.508810178315338 0.347953430378034 no 1178 0.305442642152243 1573 6813498
SGTC_1442 4112-3290 3 µM 0.507760526597566 0.34824980422372 no 1179 0.305810647740582 1451 704353
SGTC_2217 6934799 96.0675 µM 0.507116265578746 0.348431760115824 no 1180 0.306036621423168 1505 675606
SGTC_173 1273-0061 2.693 µM 0.506895707562015 0.348494059393203 no 1181 0.306113998819801 1400 2847414 YPL266W DIM1
SGTC_316 k060-0003 58.6 µM 0.506570873409751 0.348585820166836 no 1182 0.306227974705953 1499 6152314
SGTC_2593 nobiletin 86.24 µM 0.505644309934884 0.348847609108738 no 1183 0.306553184842302 1426 72344 An anti-infammatory.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.504675054335446 0.349121537203291 no 1184 0.30689354237744 1440 803109
SGTC_1891 st059073 26.2 µM 0.504670547783487 0.34912281101517 no 1185 0.306895125258239 1608 688754
SGTC_2180 6301957 200 µM 0.502168686886478 0.349830243474083 no 1186 0.307774433675735 1461 845462
SGTC_725 1497-0963 19 µM 0.499669043518653 0.350537569923803 no 1187 0.308654066666763 1610 3549977
SGTC_1716 st033144 30.6155 µM 0.499142024327389 0.350686767313392 no 1188 0.308839666974496 1561 674617
SGTC_3095 9117207 49.47 µM 0.497476019144173 0.351158559258558 no 1189 0.309426704868541 1500 17015229
SGTC_1172 0370-0043 85 µM 0.49559080697321 0.351692704658085 no 1190 0.310091570053798 1525 376585
SGTC_1969 st069479 40.1 µM 0.495477402394647 0.351724845422941 no 1191 0.310131584726634 1569 3895485
SGTC_1346 1488-2224 62.4 µM 0.495332799355613 0.35176582989344 no 1192 0.310182611001091 1512 3722427
SGTC_2995 9067767 71.4286 µM 0.494567490157511 0.351982768202903 no 1193 0.310452727558017 1501 11673567
SGTC_2359 9039622 200 µM 0.492237311875309 0.352643588474302 no 1194 0.311275795203077 1528 6463596
SGTC_1555 citronellol 128 µM 0.489667102159231 0.353372995778817 no 1195 0.312184742396322 1565 8842 A terpine precursor.
SGTC_1642 st009582 77.7 µM 0.488186028716974 0.353793558843199 no 1196 0.312709039862464 1564 6739311
SGTC_2143 5623677 140.463 µM 0.487604978535291 0.353958601628419 no 1197 0.312914834253626 1488 5375313
SGTC_450 aminopyrene 156 nM 0.487196742544416 0.354074574303458 no 1198 0.313059456779512 1545 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2749 bexarotene 57.39 µM 0.48634033521292 0.354317908562762 no 1199 0.313362942862919 1468 82146 An retinoic acid receptor inhibitor.
SGTC_1944 st076371 56.9 µM 0.485322306323484 0.354607242348656 no 1200 0.313723867427102 1455 24208455
SGTC_2754 granisetron 64.02 µM 0.482727455809783 0.355345103457259 no 1201 0.314644632934808 1604 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.48183033280342 0.355600332062603 no 1202 0.31496323980426 1477 688667
SGTC_3100 9120536 49.47 µM 0.480081095430328 0.356098170607971 no 1203 0.315584865014008 1484 16421196
SGTC_448 monastrol 171 µM 0.477079749449231 0.356952934692797 no 1204 0.316652667105174 1541 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_264 promethazine 12.5 mM 0.475638344567451 0.357363693256113 no 1205 0.317166026388993 1517 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1378 2093-0007 380 nM 0.473332859826563 0.358021033029495 no 1206 0.317987861051971 1539 3618014
SGTC_2043 5101342 149 µM 0.473182522566974 0.358063911834141 no 1207 0.318041482879351 1511 678451
SGTC_1756 st041558 35.5 µM 0.471702436991517 0.358486153527126 no 1208 0.318569598708947 1721 3955792
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.469284194697138 0.359176406588566 no 1209 0.31943325556067 1558 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1925 st057770 10.1 µM 0.468980593755348 0.359263097725318 no 1210 0.319541753698474 1429 5989122
SGTC_896 0964-0007 44.5 µM 0.467567643174305 0.359666651203758 no 1211 0.320046904238756 1533 6756758
SGTC_1415 3966-0071 78.1 µM 0.466516517830801 0.359966965170507 no 1212 0.320422913548587 1523 2893185
SGTC_2456 5770359 74.46 µM 0.46632455622255 0.360021819305563 no 1213 0.320491602118043 1607 3118787
SGTC_2585 alliin 100 µM 0.465802186788697 0.360171103971845 no 1214 0.320678549835134 1642 87310 A garlic compound which reacts with lipids.
SGTC_1817 st052116 64.4 µM 0.465728416216474 0.360192188117417 no 1215 0.320704954817288 1577 4361398
SGTC_3146 9095609 49.47 µM 0.465421790649243 0.360279828405931 no 1216 0.320814716196296 1601 17173999
SGTC_3034 9090421 49.47 µM 0.461852781796261 0.361300468169695 no 1217 0.322093448511684 1552 17173761
SGTC_1360 1598-0022 39.8 µM 0.461516607745686 0.361396655858963 no 1218 0.322214004480658 1613 761525
SGTC_3317 9138495 8.753 µM 0.461124680316198 0.361508807026823 no 1219 0.322354577882761 1525 17020139
SGTC_1368 1852-0141 284 µM 0.460450057605421 0.361701880133285 no 1220 0.32259660566925 1522 2838987
SGTC_503 tyrphostin 8 294 µM 0.460104343538838 0.361800835142913 no 1221 0.322720663266093 1610 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_791 1348-1292 225 µM 0.459864662622693 0.361869445318461 no 1222 0.322806683032867 1608 5437054
SGTC_818 4072-2707 53.5 µM 0.459025641161833 0.362109655470298 no 1223 0.323107876499659 1473 882871
SGTC_185 k048-0037 25.491 µM 0.456438426135346 0.362850711543668 no 1224 0.324037369462133 1611 6827589
SGTC_2583 asiatic acid 100 µM 0.45641349234466 0.362857855834665 no 1225 0.324046332624235 1557 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1530 rhein 70.4 µM 0.456107570147651 0.362945515753493 no 1226 0.324156313383971 1551 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3119 9125183 49.47 µM 0.455622699171997 0.363084466934267 no 1227 0.324330658676825 1497 22695334
SGTC_1373 2887-0003 58.5 µM 0.455375058326822 0.363155441196856 no 1228 0.324419717879044 1534 776948
SGTC_2684 capsaicin 100 µM 0.455008939745524 0.363260379977257 no 1229 0.324551403689024 1536 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_761 k216-0224 480 µM 0.454287912377294 0.363467074535082 no 1230 0.324810807496355 1711 1340404
SGTC_159 3970-0959 50 µM 0.452282627161244 0.364042131950431 no 1231 0.325532694879566 1603 6615653
SGTC_2863 9028737 58.44 µM 0.450605598771561 0.364523290118844 no 1232 0.326136915363203 1648 6460917
SGTC_1185 1319-0113 81.3 µM 0.450073808822155 0.364675911219299 no 1233 0.326328610659398 1593 4672763
SGTC_2982 9019404 25.97 µM 0.448032688855929 0.365261901585094 no 1234 0.327064802588011 1386 22333232
SGTC_2695 st077686 51.995 µM 0.444769473980049 0.366199399635045 no 1235 0.328243178348924 1511 2876092
SGTC_2990 9074105 71.4286 µM 0.444138602166711 0.366380736913516 no 1236 0.328471189480617 1562 6502001
SGTC_2674 ligustilide 100 µM 0.442519404815655 0.366846294162319 no 1237 0.329056695766843 1568 5319022 A signalling regulator.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.442477743687876 0.36685827530274 no 1238 0.329071766090346 1708 71034 A hepatoprotective.
SGTC_2777 climbazole 1.536 µM 0.442302452795761 0.366908687859882 no 1239 0.329135178133648 1594 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2709 st078560 56 µM 0.439880663115373 0.367605413895109 no 1240 0.330011770843792 1681 17250903
SGTC_2357 9067248 200 µM 0.436209255200952 0.368662474133546 no 1241 0.331342456760599 1588 9150235
SGTC_1484 3473-2379 286 µM 0.433428248831224 0.369463835239025 no 1242 0.332351840915859 1625 671917
SGTC_2861 9024595 19.48 µM 0.432345543272529 0.369775976001231 no 1243 0.332745145458378 1577 16482810
SGTC_2123 5259487 200 µM 0.432278889606302 0.369795194859581 no 1244 0.33276936414701 1683 2173474
SGTC_757 1066-0008 322 µM 0.431642614816986 0.369978674126506 no 1245 0.333000590458895 1644 6842497
SGTC_1048 3161-0300 24.5 µM 0.431232242803956 0.370097026683037 no 1246 0.333149755959337 1529 2165101
SGTC_1013 4112-3890 241 µM 0.429438410645386 0.370614517702798 no 1247 0.333802102935225 1547 705171
SGTC_3130 9127414 49.47 µM 0.42936044787485 0.37063701399422 no 1248 0.333830466373855 1574 1494646
SGTC_1738 st035555 74 µM 0.428372383598264 0.370922159939564 no 1249 0.334190013761979 1593 5331140
SGTC_599 1935-0052 86.5 µM 0.426554225729547 0.371447048151096 no 1250 0.334852022015394 1566 9557311
SGTC_506 n9-isopropylolomoucine 153 µM 0.424898452916019 0.371925265142771 no 1251 0.335455351255314 1742 6610355
SGTC_2831 7999036 19.48 µM 0.424766583046562 0.371963360041866 no 1252 0.3355034201713 1769 2988270
SGTC_647 0140-0236 81 µM 0.424520888172713 0.372034340337093 no 1253 0.335592987509947 1624 990837
SGTC_2355 9061122 103.12 µM 0.422334353681191 0.372666212970036 no 1254 0.336390493203365 1695 5302957
SGTC_3 0833-0587 95.581 µM 0.420194244403324 0.37328500149943 no 1255 0.337171779512871 1580 5382644
SGTC_29 0299-0004 12.984 µM 0.419021222820738 0.373624306315875 no 1256 0.337600311053528 1554 16871 A napthoquinone isolated from Swertia calycina.
SGTC_587 k089-0003 57 µM 0.418393787958797 0.37380583654062 no 1257 0.337829613836288 1621 9659696
SGTC_1876 myriocin 605 nM 0.413169609204992 0.37531838582957 no 1258 0.339741176249338 1702 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2949 9072542 2.23 µM 0.413137034991516 0.375327823040335 no 1259 0.339753108377537 1565 16457352
SGTC_524 r073-0010 27.8 µM 0.412860692295279 0.375407886432326 no 1260 0.339854340809758 1554 2772106
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.412768762529268 0.375434521975022 no 1261 0.339888019939146 1697 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3139 9095020 49.47 µM 0.41207940486416 0.37563427397087 no 1262 0.340140611773205 1514 25236292
SGTC_3299 9121982 43.1275 µM 0.411250913657092 0.37587438616157 no 1263 0.340444279337667 1577 17594604 YPL160W CDC60
SGTC_1805 st050013 60.3 µM 0.408395556480715 0.37670228966989 no 1264 0.341491647581107 1659 4037144
SGTC_2791 5663188 71.43 µM 0.407523027879775 0.376955390460234 no 1265 0.341811942272398 1701 54690634
SGTC_672 1441-0018 53.7 µM 0.406888366527913 0.377139524577148 no 1266 0.342044990348005 1579 251141
SGTC_826 1683-5028 118 µM 0.406051572661616 0.377382346043265 no 1267 0.342352353602553 1618 722377
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.404884860980268 0.377720984211906 no 1268 0.342781073473452 1628 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2196 6573537 42.6665 µM 0.403698454906386 0.378065435080637 no 1269 0.3432172379691 1706 2903087
SGTC_1119 parthenolide 318.541 nM 0.403624171723923 0.378087005044688 no 1270 0.343244554029394 1706 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2846 9008642 19.48 µM 0.40164089795362 0.378663038082414 no 1271 0.343974163214604 1606 2992898
SGTC_1976 st070609 63.5 µM 0.401340851835444 0.378750208658348 no 1272 0.344084595241717 1594 682556
SGTC_1799 st045822 46.1415 µM 0.400333619613931 0.379042878803866 no 1273 0.344455404447404 1725 3674992
SGTC_830 4076-0286 57.8 µM 0.39556845429856 0.380428424231666 no 1274 0.346211706314947 1665 6866659
SGTC_2907 7721985 69.9 µM 0.394414607413746 0.380764154622883 no 1275 0.34663748045644 1587 3267881
SGTC_2947 9072639 7.68 µM 0.391082246430141 0.381734262259278 no 1276 0.347868221507991 1576 16488146
SGTC_2931 9014674 55.67 µM 0.390656296542287 0.381858317303312 no 1277 0.348025653532062 1574 2996810
SGTC_460 trequinsin 123 µM 0.386968315141125 0.382932923154557 no 1278 0.349389832479261 1663 5537 A vasodilator.
SGTC_1372 2752-0194 270 µM 0.386642689703178 0.383027847496963 no 1279 0.349510374688066 1590 823334
SGTC_3193 9111931 49.47 µM 0.385908273597975 0.383241965783617 no 1280 0.349782301469083 1658 17087244
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.384096143712145 0.383770442930605 no 1281 0.350453594778892 1830 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_651 3253-0966 34.4 µM 0.382681095595959 0.384183268291339 no 1282 0.350978116475189 1630 781462
SGTC_2024 5144227 134 µM 0.380525375747278 0.384812429296472 no 1283 0.351777731801484 1717 3475211
SGTC_860 0443-0016 25.1 µM 0.379954204296221 0.384979180357495 no 1284 0.351989704976844 1673 5337942
SGTC_400 oxethazaine 37.5 µM 0.379144908525692 0.385215487216383 no 1285 0.35229012962299 1642 4621 A local anesthetic.
SGTC_1625 st003711 30.1 µM 0.37697934724968 0.385848020451949 no 1286 0.353094476543898 1723 24207034 YER133W GLC7
SGTC_2495 cafestol 54.53 µM 0.376634765361055 0.38594869653519 no 1287 0.353222524064374 1712 16667697 An anti-infammatory.
SGTC_2978 9011784 42.97 µM 0.375570955302998 0.386259557100702 no 1288 0.353617943428338 1845 2994934
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.374074280602033 0.386697030529983 no 1289 0.354174526508066 1647 390807
SGTC_1140 3229-1848 2.98 µM 0.372746922941201 0.387085133630606 no 1290 0.354668404836805 1759 2849525
SGTC_1334 1486-0610 236 µM 0.372388945085108 0.387189821313208 no 1291 0.354801641791791 1696 3742339
SGTC_1050 3232-1156 69.3 µM 0.372327556137467 0.387207774830967 no 1292 0.354824492130637 1641 700529
SGTC_1638 st008370 60.6 µM 0.372161634420752 0.3872563007092 no 1293 0.354886254516583 1621 24207134
SGTC_615 k087-0205 167 µM 0.371163334160438 0.387548303252581 no 1294 0.355257940372065 1597 9642773
SGTC_1042 0350-0096 82 µM 0.366525668459524 0.388905650988943 no 1295 0.356986431275078 1630 3122515
SGTC_463 ikarugamyin 104 µM 0.366486673043654 0.388917069908226 no 1296 0.357000977655254 1714 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3209 9113616 49.47 µM 0.365958898478143 0.389071626102374 no 1297 0.357197872760375 1868 16649353
SGTC_2388 9080168 200 µM 0.365034365133265 0.389342413456776 no 1298 0.357542876984293 1600 15943073
SGTC_116 0155-0182 31.788 µM 0.361877523054223 0.390267427917519 no 1299 0.358721778611526 1670 771486
SGTC_3318 9139014 38.6185 µM 0.360688252563448 0.390616068153369 no 1300 0.359166253748336 1684 16643984
SGTC_636 0kpi-0074 126 µM 0.360634086115953 0.390631949398545 no 1301 0.35918650233292 1683 616434
SGTC_260 nsc-65238 3.989 µM 0.35931181912161 0.391019685887949 no 1302 0.359680916767827 1744 3246252
SGTC_497 capsazepine 133 µM 0.358585675506834 0.391232663565074 no 1303 0.359952532184859 1603 2733484 A calcium channel blocker.
SGTC_658 3253-0951 102 µM 0.358409585240193 0.391284315697168 no 1304 0.360018409749127 1701 1184878
SGTC_2200 6600604 21.907 µM 0.357921764034421 0.391427417122006 no 1305 0.360200931452768 1679 2904777
SGTC_699 0375-0592 111 µM 0.357317422889599 0.391604719828256 no 1306 0.36042709409911 1790 762578
SGTC_2171 5739187 198.077 µM 0.356996120611003 0.391698993247583 no 1307 0.360547354974067 1631 2262761
SGTC_1540 guanosine 70.6 µM 0.354786264160752 0.392347560064646 no 1308 0.361374859731539 1774 6802 Guanosine is a purine nucleoside
SGTC_2539 epi(13)torulosol 80 µM 0.352727457830859 0.392952064669647 no 1309 0.362146386213315 1640 6708597
SGTC_667 1498-1044 59 µM 0.35151006678879 0.393309635380673 no 1310 0.362602860768287 1725 6739982
SGTC_681 1642-0006 26.6 µM 0.350995814325689 0.393460708089484 no 1311 0.362795744284011 1661 4446530
SGTC_1339 1486-1321 22.7 µM 0.350557491291319 0.393589487561581 no 1312 0.362960176017425 1686 3469382
SGTC_3195 9113082 49.47 µM 0.350431523862138 0.393626498993527 no 1313 0.363007435893109 1834 17018038
SGTC_2844 9010103 25.97 µM 0.350255821898154 0.393678124905993 no 1314 0.363073358425058 1692 2480525
SGTC_2809 7964133 12.99 µM 0.346958430492285 0.394647331953465 no 1315 0.364311274371605 1727 1253665
SGTC_2247 cerulenin 830 nM 0.346676516101516 0.394730225820162 no 1316 0.364417177387404 1793 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1262 0737-0114 49.6 µM 0.345453217837436 0.395089978563357 no 1317 0.364876837325388 1832 765919
SGTC_2693 st077581 40.7 µM 0.344816203330912 0.395277349928627 no 1318 0.365116275417691 1734 25238761
SGTC_416 estradiol valerate 100 µM 0.343371139036174 0.395702490661684 no 1319 0.365659634425145 1735 13791 A steroid.
SGTC_2409 alverine citrate 63.97 µM 0.34295586290328 0.39582468869239 no 1320 0.365815832442711 1822 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1973 st070275 50.2 µM 0.339924055968354 0.396717129536127 no 1321 0.366956860083267 1778 17118334
SGTC_2484 5809818 12.04 µM 0.338863887316125 0.397029328105772 no 1322 0.367356135150804 1719 2870548
SGTC_1523 st012844 44.7 µM 0.333797364646829 0.398522226284646 no 1323 0.369266236095856 1722 4274103
SGTC_1152 3909-8331 15.9 µM 0.333780168701813 0.39852729577333 no 1324 0.369272724571319 1712 16001939
SGTC_3285 9112818 20.8695 µM 0.333778505601897 0.398527786068095 no 1325 0.36927335210397 1733 17017947 YPR165W RHO1
SGTC_1485 3909-9022 254 µM 0.332638508210718 0.398863903791209 no 1326 0.369703585876095 1752 714516
SGTC_428 3448-4153 16.5 µM 0.331616978272606 0.399165156213672 no 1327 0.370089248798917 1643 3834874
SGTC_1594 piperine 70.1 µM 0.331077767939777 0.399324195283999 no 1328 0.370292872082555 1697 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2477 5967686 25.23 µM 0.330026728929124 0.399634245264658 no 1329 0.370689882896377 1681 776118
SGTC_2338 7999974 200 µM 0.329117671518091 0.399902462614967 no 1330 0.371033373847846 1913 315925
SGTC_2797 7859098 81.82 µM 0.327248423375626 0.400454132484283 no 1331 0.371739999364901 1708 972681
SGTC_2316 5844804 197.44 µM 0.32655714532427 0.400658199256475 no 1332 0.37200143049041 1886 776813
SGTC_144 4161-2749 112.381 µM 0.326451165697832 0.400689487069438 no 1333 0.372041515637015 1780 797501 YMR168C CEP3
SGTC_387 norethindrone acetate 66.7 µM 0.325216870872086 0.401053928371901 no 1334 0.372508470500534 1706 541197
SGTC_1429 4049-0205 9.46 µM 0.325096608861848 0.401089441874661 no 1335 0.372553977711436 1763 22774478
SGTC_3294 9122953 26.2835 µM 0.323043466643482 0.401695862858096 no 1336 0.373331161845424 1692 16459826
SGTC_1209 2323-2347 50.3 µM 0.322818194299168 0.401762414277195 no 1337 0.373416466531865 1871 5412760
SGTC_2954 9074818 52.69 µM 0.322045722902288 0.401990644417674 no 1338 0.373709028131619 1799 16648742
SGTC_2037 5169046 200 µM 0.320300143411881 0.40250650670289 no 1339 0.374370407226146 1790 5718022
SGTC_2451 5856223 45.7 µM 0.318408519018338 0.403065720601354 no 1340 0.375087538523935 1712 2179896
SGTC_2466 5983409 37.09 µM 0.317387409793482 0.403367669826982 no 1341 0.375474829644831 1738 2879657
SGTC_2569 tetrandrine 100 µM 0.312258698409518 0.404885134066493 no 1342 0.377421962845153 1677 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_698 k064-0052 127 µM 0.311153860393999 0.405212217645401 no 1343 0.377841828600258 1809 5088751
SGTC_343 4130-2827 29.8 µM 0.309633210391855 0.40566250921088 no 1344 0.378419949179629 1716 1118244
SGTC_2364 9055074 200 µM 0.308869129355667 0.405888814393228 no 1345 0.378710540288124 1704 6470630
SGTC_1216 1165-0504 9.65 µM 0.308190807863961 0.406089745710452 no 1346 0.378968573274468 1893 6304004
SGTC_701 4424-0219 185 µM 0.307945982795751 0.40616227348254 no 1347 0.379061717801843 1901 2911779
SGTC_2216 7189485 200 µM 0.307645019220904 0.406251436320155 no 1348 0.379176230036683 1849 731273
SGTC_2144 5628481 200 µM 0.307277505779312 0.406360321674748 no 1349 0.379316077900047 1772 2818399
SGTC_2261 9010538 184.68 µM 0.306445264288299 0.406606921478751 no 1350 0.379632824516848 1708 6457250
SGTC_1064 honokiol 6.76 µM 0.303673341676746 0.407428530918507 no 1351 0.380688384853057 1786 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1938 st074717 56.4 µM 0.303502583668252 0.407479157663893 no 1352 0.380753439395945 1738 17250979
SGTC_3147 9097027 49.47 µM 0.303316135840659 0.407534437929484 no 1353 0.380824475219067 1825 25236841
SGTC_3280 9140961 49.47 µM 0.300123164354104 0.408481412920726 no 1354 0.382041605295018 1756 4901226
SGTC_72 0744-0168 198.391 µM 0.299189217337516 0.408758505263878 no 1355 0.382397838015522 1812 677577
SGTC_2639 lactacystin 53 µM 0.29915342680756 0.408769124849331 no 1356 0.382411491476743 1870 3870 A proteasome inhibitor.
SGTC_1511 0906-3109 28.5 µM 0.2989810152293 0.408820282881199 no 1357 0.382477265526476 1763 2882180
SGTC_656 4090-1979 187 µM 0.297142110046412 0.409366020032037 no 1358 0.383179008115912 1913 22330961
SGTC_789 1309-1135 70.6 µM 0.293701624113824 0.410387533961029 no 1359 0.384492956578793 1701 3092424
SGTC_380 3970-0968 6 µM 0.292827955178465 0.410647031933078 no 1360 0.384826829628726 1780 2891601
SGTC_2835 9006588 71.43 µM 0.292557292300853 0.410727432418334 no 1361 0.384930280934919 1749 2345538
SGTC_2274 7947094 46.08 µM 0.292401520829581 0.410773706079339 no 1362 0.384989822781527 1756 2971028
SGTC_1897 st060201 15 µM 0.292182451914406 0.410838785056492 no 1363 0.385073563934066 1738 611878
SGTC_1117 retinoic acid 1.10837 µM 0.291535809086541 0.411030898065089 no 1364 0.385320780484124 1935 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2386 9075165 157.42 µM 0.290385869159045 0.411372589772224 no 1365 0.385760526487177 1817 16452277
SGTC_973 1325-0077 65.9 µM 0.288188030020197 0.412025839789232 no 1366 0.386601405475851 1900 2835149
SGTC_2881 9058953 51.95 µM 0.287414339267848 0.412255857189205 no 1367 0.386897541512482 1788 17122249
SGTC_1657 st012939 43.4 µM 0.286289749406113 0.412590250234989 no 1368 0.387328104252836 1898 24207257
SGTC_167 3672-0051 66.205 µM 0.285953475438201 0.412690252512359 no 1369 0.387456877731611 1755 3237971
SGTC_1380 2291-0730 164 µM 0.285055212470228 0.412957408729393 no 1370 0.38780092117335 1765 2999191
SGTC_225 nsc-122657 1.016 µM 0.283525671300745 0.413412408798872 no 1371 0.388386952900324 1863 275685
SGTC_2987 9018338 71.43 µM 0.281464971137092 0.41402559912462 no 1372 0.3891768957416 1801 5055682
SGTC_2459 5811157 9.22 µM 0.280597187711856 0.414283883113319 no 1373 0.389509686645827 1899 2870684 YBR192W RIM2
SGTC_1312 1218-2183 165 µM 0.280081907163896 0.414437266942388 no 1374 0.389707332701086 1876 6744073
SGTC_1771 st048882 4.1505 µM 0.279717041185831 0.414545884680714 no 1375 0.389847301524322 1737 4580403
SGTC_2517 totarol 10 µM 0.279551426701665 0.414595188969664 no 1376 0.389910838785006 1746 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_301 4119-0100 24.5 µM 0.278959203144353 0.414771507990912 no 1377 0.390138066776683 1828 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_781 4335-2806 94.4 µM 0.278553740222844 0.414892233839283 no 1378 0.390293658949252 1936 845254
SGTC_755 1995-0008 37.3 µM 0.277606318879972 0.41517435813832 no 1379 0.390657290488062 1906 689533
SGTC_2561 acetosyringone 100 µM 0.276866517866742 0.415394687422359 no 1380 0.390941301405443 1845 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_341 1486-1430 230 µM 0.275170844089856 0.415899797261 no 1381 0.391592492832205 1770 2054753 YPL210C SRP72
SGTC_2490 carminic acid 95.39 µM 0.271399455368446 0.417023721249431 no 1382 0.393041910440986 1844 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1193 1488-0126 41.5 µM 0.269332142575983 0.41764009643361 no 1383 0.393837049760624 1804 1384710
SGTC_371 0195-0006 7.36 µM 0.268108989622505 0.418004878366005 no 1384 0.394307713179837 1765 3928593
SGTC_3029 9088683 49.47 µM 0.266904823879178 0.41836406664705 no 1385 0.394771221212399 1850 25236615
SGTC_3008 9078912 71.4286 µM 0.266827120851288 0.418387246875335 no 1386 0.394801135821763 1815 16648731
SGTC_2975 9084847 53.72 µM 0.266523773879102 0.418477743513882 no 1387 0.394917926217554 1796 27211724
SGTC_1828 st055811 49 µM 0.266484384172276 0.418489494849611 no 1388 0.394933092182801 1966 5877589
SGTC_940 3232-1287 54.8 µM 0.266180596236126 0.418580127925023 no 1389 0.395050063042934 1981 1585493 YIL048W NEO1
SGTC_990 3985-0011 41.3 µM 0.265341045830988 0.418830624572931 no 1390 0.395373373668151 1835 5399565 YGL099W LSG1
SGTC_2515 chrysin 20.77 µM 0.263253168756806 0.419453726934547 no 1391 0.396177726398362 1922 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_533 1222-0222 6.71 µM 0.262724328992996 0.419611585072344 no 1392 0.396381531753515 1952 3982874
SGTC_1936 st074407 74.3 µM 0.261148733092908 0.420081975460659 no 1393 0.396988905802091 1778 809813
SGTC_914 3820-6779 408 µM 0.260721154231577 0.420209647833066 no 1394 0.397153775702349 1813 2893481
SGTC_560 2332-1943 155 µM 0.259564121886618 0.420555172514554 no 1395 0.397600007258466 1856 21177716
SGTC_1289 0976-0073 69.1 µM 0.259298811647602 0.42063441077508 no 1396 0.397702348115282 1905 3391136
SGTC_1205 4161-2785 76 µM 0.259113517499194 0.420689753125005 no 1397 0.397773827715786 1746 3498106
SGTC_2499 avocadenofuran 51.48 µM 0.258703760329294 0.420812142072324 no 1398 0.39793190899629 1753 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2762 leflunomide 42.06 µM 0.255936271510917 0.421638953553522 no 1399 0.399000023255146 1842 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2360 9040895 200 µM 0.254097283833514 0.422188558550919 no 1400 0.399710200855768 1811 4914414
SGTC_3012 9080433 71.4286 µM 0.253448123589228 0.422382604643495 no 1401 0.399960972001582 1993 17688859
SGTC_2222 6885208 172.143 µM 0.251854195063961 0.422859139406159 no 1402 0.400576882761039 1894 609514
SGTC_140 0062-0056 502.533 µM 0.251491820355837 0.42296749388344 no 1403 0.400716942717596 1822 3758964
SGTC_305 1682-2595 20.8 µM 0.249844896320291 0.423460017657063 no 1404 0.40135364912736 1892 226033
SGTC_3077 9117319 49.47 µM 0.248733414343978 0.423792481514335 no 1405 0.401783500023188 1923 17154678
SGTC_1115 galangin 695.678 nM 0.24828221045121 0.423927460049859 no 1406 0.401958031083203 1968 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_529 4076-0302 30.3 µM 0.247911929130242 0.424038237106565 no 1407 0.402101274933827 1839 5816522
SGTC_2824 7998404 51.95 µM 0.24777050256371 0.424080549274693 no 1408 0.402155989471758 1882 837851
SGTC_2492 derrusnin 100 µM 0.247474218000973 0.424169194878629 no 1409 0.402270621059359 1862 1715307 Part of coumarin class of compounds.
SGTC_2616 abietic acid 100 µM 0.246980419293226 0.424316943413273 no 1410 0.4024616889367 2038 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_643 k048-0106 28.4 µM 0.245928177643697 0.424631818012096 no 1411 0.402868915474547 1938 6763920
SGTC_3228 9131799 49.47 µM 0.244822991229334 0.424962587682934 no 1412 0.403296745564534 1892 17015818
SGTC_1503 4585-0012 61.3 µM 0.244091385950283 0.425181577866174 no 1413 0.403580021913574 1948 2922052
SGTC_2962 9082311 13.18 µM 0.243556801248578 0.4253416088123 no 1414 0.403787044220056 1816 16459453
SGTC_2746 daunorubicin 9.88 µM 0.242299126870781 0.42571814919943 no 1415 0.404274195138638 1983 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2332 7982454 138.89 µM 0.241084178814786 0.426081961915419 no 1416 0.404744937331979 1946 2981748
SGTC_3002 9075603 71.4286 µM 0.240964135588106 0.426117911936511 no 1417 0.404791456621003 1962 20105405
SGTC_788 1182-0090 188 µM 0.240174713109759 0.426354340013246 no 1418 0.40509740801813 1990 5715185
SGTC_1130 3454-2858 15.9 µM 0.239904330104163 0.426435324458428 no 1419 0.405202211969075 1791 715628 YIL048W NEO1
SGTC_3112 9123419 49.47 µM 0.23712107615935 0.427269137458055 no 1420 0.406281431080433 1989 17015854
SGTC_3163 9099914 49.47 µM 0.236480050128876 0.427461223551687 no 1421 0.406530093010295 1997 16268368
SGTC_2298 7976326 193.81 µM 0.236107465317044 0.427572878032549 no 1422 0.406674640598871 1957 2235818
SGTC_2243 6634756 200 µM 0.232016657831399 0.42879917175027 no 1423 0.408262537859196 1995 885676
SGTC_2720 fluspirilene 36.88 µM 0.23038035875535 0.429289875275828 no 1424 0.408898111076334 1964 3396 An atypical antipsychotic.
SGTC_1735 st034310 56.75 µM 0.229616965943009 0.429518843684916 no 1425 0.409194711090183 1951 871153
SGTC_2612 dictamnine 15.46 µM 0.229096181210008 0.429675058991324 no 1426 0.409397080747781 1895 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1643 st009866 20.2 µM 0.227677824721825 0.43010056692337 no 1427 0.409948356506433 1992 3156273 YOR207C RET1
SGTC_3142 9086498 49.47 µM 0.227513653074305 0.430149823783875 no 1428 0.410012176981664 2045 25236367
SGTC_1274 0865-0114 173 µM 0.227445198091681 0.43017036283742 no 1429 0.410038789038121 1921 870624
SGTC_473 2-arachidonoylglycerol 10 µM 0.226371869348902 0.430492426251978 no 1430 0.410456102544369 1844 5282280 An endocannabinoid.
SGTC_86 0417-1630 471.922 µM 0.225943713058456 0.430620911898666 no 1431 0.410622599342669 2018 3634867
SGTC_2919 7978188 46.38 µM 0.225063868983657 0.430884967810614 no 1432 0.410964794140887 2026 2980291
SGTC_782 0083-0095 30.5 µM 0.225052203036493 0.430888469164165 no 1433 0.410969331794287 1894 3591729 An indicator and reagent.
SGTC_1295 1013-0063 9.78 µM 0.224336722519356 0.43110321994444 no 1434 0.41124765192894 2034 6826038
SGTC_2304 7443016 91.4 µM 0.22409078779955 0.431177041718659 no 1435 0.411343330245396 1899 939854
SGTC_2317 5986382 200 µM 0.222121421611852 0.431768269258962 no 1436 0.412109681164746 1988 877883
SGTC_2307 7538926 6.34 µM 0.221867389890769 0.431844543812101 no 1437 0.412208558480963 1890 96582
SGTC_2013 4024628 200 µM 0.221096983039101 0.432075878632039 no 1438 0.412508459660219 1947 5230760
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.220254847968458 0.432328778369661 no 1439 0.412836341377946 1965 4000243
SGTC_3255 9139072 49.47 µM 0.218357039372918 0.432898806611261 no 1440 0.413575467745388 1921 17646060
SGTC_721 1187-1332 279 µM 0.218103673529265 0.43297491849611 no 1441 0.413674167621041 1907 25730
SGTC_1926 methyl fluorone black 53.6 µM 0.216010969690148 0.433603668043799 no 1442 0.414489598422439 1954 72721 Reacts with homocysteine.
SGTC_906 1165-0455 526 µM 0.215560084545217 0.433739157830236 no 1443 0.414665336097644 1880 3252859
SGTC_2269 7935389 174.42 µM 0.214696138439358 0.433998793076531 no 1444 0.415002116729496 1843 97605
SGTC_232 clozapine 119 µM 0.213590655891168 0.434331056976773 no 1445 0.415433143385366 1952 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2843 9000894 45.46 µM 0.212648915079211 0.434614143256813 no 1446 0.415800407592765 1953 2242070
SGTC_199 4063-0024 41.6 µM 0.212500337840163 0.434658808481522 no 1447 0.415858357121142 2014 306215
SGTC_1118 chelidonine 707.474 nM 0.211828267815372 0.434860856288621 no 1448 0.416120507195268 2072 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2478 5763493 32.33 µM 0.211216657193047 0.435044742666554 no 1449 0.416359106696157 1962 1365576 YLR208W SEC13
SGTC_1846 st056244 14.8 µM 0.210438262937246 0.435278794396971 no 1450 0.416662815841615 1957 5393182
SGTC_1311 1190-0148 100 µM 0.208032257953603 0.436002387808732 no 1451 0.417601890051567 2013 1961333
SGTC_927 2425-1185 123 µM 0.207564217974735 0.436143173353946 no 1452 0.417784622878038 1878 730375
SGTC_3239 9133757 49.47 µM 0.207044202098258 0.436299602639385 no 1453 0.417987669025591 1989 17036923
SGTC_1046 2001-0062 216 µM 0.203483480649533 0.437370992356564 no 1454 0.419378578062747 1896 739778
SGTC_640 3381-0960 37.1 µM 0.202808009240337 0.437574287833716 no 1455 0.419642548781408 2024 1745025
SGTC_750 4073-0104 132 µM 0.202446296779517 0.437683158594749 no 1456 0.41978391900791 2029 22330957
SGTC_472 calcifediol 10 µM 0.202150487719711 0.437772196793691 no 1457 0.419899539513153 1959 5283731 A vitamin D metabolite.
SGTC_2405 ticlatone 3.52 µM 0.200737605816776 0.438197516068393 no 1458 0.420451876495479 1826 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2491 paeonol 100 µM 0.200310362888314 0.438326142918111 no 1459 0.420618929189535 1921 11092 Increases levels of cortical cytochrome oxidase.
SGTC_674 0498-0004 451 µM 0.199340296406307 0.438618217786332 no 1460 0.420998279831958 1901 4231473
SGTC_589 1227-0070 34.1 µM 0.195272120969987 0.439843456733605 no 1461 0.422589960588109 1988 2841384
SGTC_1319 1306-0155 43.7 µM 0.194509333157221 0.440073255038562 no 1462 0.42288854424237 1983 3122360
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.192811600634208 0.440584788187251 no 1463 0.423553258986692 2044 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_410 α-linolenic acid 100 µM 0.19223760370615 0.44075775807935 no 1464 0.423778045840508 2033 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2789 5281112 71.43 µM 0.191880899006915 0.440865254200533 no 1465 0.423917749903586 1887 765948
SGTC_836 0330-0104 1.35 µM 0.191865360624191 0.440869936928921 no 1466 0.423923835757731 2065 46494820
SGTC_312 4092-0653 6.84 µM 0.190582831502746 0.441256475065311 no 1467 0.424426221058586 2042 1148278
SGTC_3214 9129694 49.47 µM 0.190310342935891 0.441338606910538 no 1468 0.424532974636601 2073 17158655
SGTC_675 1309-0189 238 µM 0.18813218389807 0.441995224738834 no 1469 0.425386516212997 1955 4246530
SGTC_1056 3448-1962 115 µM 0.187685039123374 0.442130038731225 no 1470 0.425561779450591 1988 715507
SGTC_499 genistein 192 µM 0.186748353961989 0.442412470687316 no 1471 0.42592897098517 2095 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1845 st056753 3.01 µM 0.185626222601124 0.442750857431879 no 1472 0.426368944142788 1897 5375839
SGTC_1272 0839-0021 27 µM 0.185320632870488 0.442843017448872 no 1473 0.426488777815386 1998 5027250
SGTC_644 1498-1197 63.3 µM 0.185135742054652 0.442898778484002 no 1474 0.426561284023757 2035 6741615
SGTC_495 decylubiquinone 155 µM 0.184325834680114 0.443143050948109 no 1475 0.426878924001836 1934 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1841 st054148 70 µM 0.184021394868432 0.443234877242602 no 1476 0.426998335429768 1943 675442
SGTC_2129 girgensonine 121.053 µM 0.183741230678412 0.44331938412554 no 1477 0.427108231062195 2001 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2339 9000433 200 µM 0.183468493325954 0.443401653302551 no 1478 0.427215218919437 1898 2988954
SGTC_989 1501-0895 10.3 µM 0.182468958931478 0.443703176184436 no 1479 0.427607356290278 2100 2830112
SGTC_1688 st021091 57.6 µM 0.182145172633811 0.443800857637701 no 1480 0.427734399498718 2106 3656366
SGTC_1454 4239-0054 42.6 µM 0.179370481795579 0.444638079506743 no 1481 0.428823403797917 2080 1340767
SGTC_1221 2958-7315 257 µM 0.178774516255632 0.444817935640464 no 1482 0.42905737799 2012 4562705
SGTC_1401 3807-4679 7.6 µM 0.177220633874446 0.445286934342507 no 1483 0.429667544349997 2013 3291456
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.177192621541996 0.445295389836176 no 1484 0.429678545559595 2004 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2635 hydroquinidine 100 µM 0.175948629464061 0.445670912599001 no 1485 0.430167150229493 1987 442912 An experimental heart treatment.
SGTC_892 0929-0076 29 µM 0.174957233768505 0.445970219240753 no 1486 0.430556618852629 1947 5751038
SGTC_2437 5741531 144.16 µM 0.174050387887067 0.446244026897236 no 1487 0.430912931353778 2096 2262990
SGTC_944 3370-0224 231 µM 0.1737074798167 0.446347569208528 no 1488 0.431047679427575 1963 4580514
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.173626391423798 0.446372054672229 no 1489 0.431079544840726 2028 5393153
SGTC_1992 st073643 23.3 µM 0.17224289099048 0.446789848108176 no 1490 0.431623289797136 2015 3161292
SGTC_900 1112-0045 141 µM 0.171457235589322 0.447027128907959 no 1491 0.431932126755586 2108 56211 YIL048W NEO1
SGTC_230 MPP+ 141.667 µM 0.17130450971349 0.447073256828179 no 1492 0.431992167320598 1961 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_834 0312-0008 75.7 µM 0.170715337638063 0.447251211651554 no 1493 0.432223801090218 2047 6385573 YIL048W NEO1
SGTC_1159 4092-0538 61.2 µM 0.170086919121982 0.447441032259701 no 1494 0.432470890326018 2007 717301
SGTC_2950 9072895 21.46 µM 0.170070152923362 0.447446096836372 no 1495 0.432477483026078 1954 17332245
SGTC_338 4055-0136 114 µM 0.168495719175849 0.447921725147195 no 1496 0.433096655564673 2005 2900563
SGTC_2025 5147754 141 µM 0.168346151596916 0.447966912646517 no 1497 0.433155484097175 2089 315777 YLR208W SEC13
SGTC_3282 9108498 15.4605 µM 0.167806873510706 0.448129845457492 no 1498 0.433367607451554 1975 16459645
SGTC_1518 st038567 90.8 µM 0.166690389612391 0.448467198016648 no 1499 0.433806833858518 2112 77966
SGTC_969 1313-0238 134 µM 0.165792117466407 0.448738643602065 no 1500 0.434160274811931 1991 5212874
SGTC_1507 4075-3230 155 µM 0.164004473882039 0.449278916378519 no 1501 0.434863810927039 2139 659771
SGTC_774 k060-0086 136 µM 0.162755980767037 0.449656299583181 no 1502 0.435355284145807 2142 5911235
SGTC_55 0767-0285 6.563 µM 0.162300298038327 0.449794050597628 no 1503 0.43553468999572 2117 3116166
SGTC_1419 3993-2473 62.6 µM 0.16110633539132 0.450155009245582 no 1504 0.436004825254143 2038 704026
SGTC_3297 9117502 71.43 µM 0.159360677257719 0.450682830551147 no 1505 0.436692358971845 2175 7453720
SGTC_1930 st074634 34.3 µM 0.158733960060114 0.450872347567788 no 1506 0.436939240560726 2053 684253 YOR116C RPO31
SGTC_366 0181-0206 4.31 µM 0.158341156734227 0.450991135587333 no 1507 0.437093989402244 2142 274874
SGTC_2677 mitomycin C 100 µM 0.156874197146554 0.451434798923589 no 1508 0.437671997870547 2046 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2373 9071805 200 µM 0.152392695139264 0.452790545871209 no 1509 0.439438609111523 2178 10149009
SGTC_2300 7976697 71.57 µM 0.151210711973098 0.453148212595938 no 1510 0.439904750262506 1998 2236109
SGTC_2191 5911152 200 µM 0.150896036894948 0.453243439325653 no 1511 0.440028863395229 2111 2875902
SGTC_3000 9075062 71.4286 µM 0.147533140942825 0.454261283119744 no 1512 0.441355611617187 2017 17057871
SGTC_2138 5575593 77.673 µM 0.147016093659154 0.454417804032285 no 1513 0.441559658722901 2037 762213
SGTC_1342 1486-1464 234 µM 0.142499239698793 0.455785447568041 no 1514 0.443342839937777 2092 3253938
SGTC_662 k832-1615 104 µM 0.141505953499516 0.456086272331373 no 1515 0.443735128578461 2080 5878478
SGTC_2552 juarezic acid 87.02 µM 0.141048499945539 0.456224824319225 no 1516 0.44391581394081 2188 1549512
SGTC_1075 aripiprazole 15.2 µM 0.139738118625401 0.456621737593686 no 1517 0.444433453782398 2054 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2061 5245884 80.95 µM 0.139336439187494 0.456743414604994 no 1518 0.44459214820561 2088 573863
SGTC_1203 3992-3522 103 µM 0.13791119714255 0.457175182553394 no 1519 0.445155300466205 2198 5322312
SGTC_2966 9084041 48.03 µM 0.137532796034057 0.45728982525944 no 1520 0.445304835776374 1910 17741380
SGTC_1453 4237-0541 195 µM 0.135730233612446 0.457835989185977 no 1521 0.446017272961942 2168 739892
SGTC_1426 4048-4480 71.7 µM 0.135702061765013 0.457844525695241 no 1522 0.446028408873836 2149 14224343
SGTC_566 0958-0068 16.5 µM 0.135422328832043 0.457929290192449 no 1523 0.446138985446514 2128 6815365
SGTC_2587 piperic acid 92.2 µM 0.134349253818551 0.45825447042295 no 1524 0.446563203661821 2051 5370536
SGTC_3007 9078383 71.4286 µM 0.13428014941114 0.458275412497788 no 1525 0.446590524774428 2054 6496995
SGTC_3184 9108758 49.47 µM 0.133916818320059 0.458385521805718 no 1526 0.446734175491169 2143 902885
SGTC_2759 disulfiram 3.38 µM 0.133826719751111 0.458412827123006 no 1527 0.44676979896945 2096 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_700 3453-2283 142 µM 0.133404442332105 0.4585408053416 no 1528 0.446936766169595 2143 565664
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.133001613876911 0.45866289323259 no 1529 0.447096052075628 2063 4213774
SGTC_1079 idarubicin 2.36 µM 0.132307942299807 0.458873138009436 no 1530 0.447370362779225 2190 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_404 fumagillin 50 µM 0.130713196205763 0.459356532809047 no 1531 0.448001096426668 2066 12015870 A methionine aminopeptidase binder.
SGTC_3314 9135860 59.4275 µM 0.130579453693061 0.459397075191801 no 1532 0.448053998558607 2176 25252478
SGTC_1711 st032263 62.8 µM 0.130377933278973 0.459458164401439 no 1533 0.448133712126413 2098 3958979
SGTC_3154 9100113 49.47 µM 0.128405853203587 0.460056034099616 no 1534 0.448913899658831 2063 25237525
SGTC_1082 camptothecin 424.86 nM 0.125992164635674 0.460787907738411 no 1535 0.449869063432538 2107 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2244 6635614 200 µM 0.123732300243274 0.461473259596039 no 1536 0.450763618135507 2028 836499
SGTC_111 0083-0039 52.457 µM 0.123178985900551 0.461641081434975 no 1537 0.450982682826322 2204 759313
SGTC_2320 7373003 200 µM 0.122910564233721 0.461722496964448 no 1538 0.451088960005937 2066 5415828
SGTC_1275 0867-0008 21.1 µM 0.122340222900544 0.461895493691619 no 1539 0.451314788982428 2118 3422836
SGTC_1588 farnesol 29.9 µM 0.120167950859086 0.462554456012788 no 1540 0.452175052638232 2099 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3243 9134147 49.47 µM 0.120119291376864 0.462569218130998 no 1541 0.452194325363897 2211 24282180
SGTC_595 3909-8003 73.7 µM 0.118934311020981 0.462928728576418 no 1542 0.452663699206711 2141 699517
SGTC_1135 dihydrocapsaicin 536.708 nM 0.118363891715068 0.4631017985461 no 1543 0.452889667425283 2116 107982 A Capsaicinoid.
SGTC_2882 9058044 58.44 µM 0.11576756457049 0.46388963358869 no 1544 0.453918378677142 2035 18076804
SGTC_2536 dehydroabietamide 32.04 µM 0.114234152074459 0.464355002264802 no 1545 0.454526089830115 2183 3983547
SGTC_809 3998-0021 90 µM 0.113703563389003 0.464516039701689 no 1546 0.454736393834194 2219 715485
SGTC_853 0419-0306 21 µM 0.112741994744829 0.46480789741332 no 1547 0.455117553243668 2049 762713
SGTC_2343 7990716 14.84 µM 0.112349753427668 0.464926956921628 no 1548 0.455273046976731 2145 6456862
SGTC_618 k072-0232 33.2 µM 0.111795362789433 0.465095240000349 no 1549 0.455492832216442 2132 5872756 YGL099W LSG1
SGTC_1961 st076550 68.7 µM 0.110910035148168 0.465363990626039 no 1550 0.455843843902095 2136 1579337
SGTC_1574 spiramycin 23.7 µM 0.11069057575226 0.465430612309031 no 1551 0.455930859756962 2191 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_603 3794-0023 45.9 µM 0.109229733184757 0.465874107512934 no 1552 0.456510138863341 2216 3802260
SGTC_420 mitomycin C 81.9 mM 0.107755021026897 0.466321856355103 no 1553 0.457095011542931 2138 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_364 0083-0097 67.7 µM 0.104798606492791 0.467219604218008 no 1554 0.458267807909686 2122 5207356
SGTC_2862 9027634 71.43 µM 0.104716662881806 0.467244489695165 no 1555 0.458300319795027 2172 5012562
SGTC_3162 9099653 49.47 µM 0.103875345466678 0.467499996994115 no 1556 0.458634136356176 2215 25237511
SGTC_2617 dihydrotanshinone i 20.83 µM 0.101366537401919 0.468261998712 no 1557 0.459629749451127 2175 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_231 b-estradiol 524 µM 0.101282821915009 0.46828742768559 no 1558 0.459662976095995 2127 450 A steroid.
SGTC_812 4251-0442 148 µM 0.100506996326771 0.468523094505845 no 1559 0.459970914349772 2227 5723007
SGTC_2083 5306046 65.942 µM 0.0972264712550733 0.46951971637879 no 1560 0.461273273303193 2158 539837
SGTC_3180 9109287 49.47 µM 0.0971544601979822 0.46954159546696 no 1561 0.461301866195071 2172 18891271
SGTC_748 act1.228 77.9 µM 0.0956061960079789 0.470012026039509 no 1562 0.461916672021756 2159 4421505 YNR035C ARC35
SGTC_570 0987-0065 62.6 µM 0.0950634425736385 0.470176948282358 no 1563 0.462132217565512 2241 3104428
SGTC_3053 9095903 49.47 µM 0.0949683961493626 0.47020582982342 no 1564 0.462169964825984 2245 17174018
SGTC_1091 telmisartan 47.6 µM 0.0944157696717779 0.470373758276123 no 1565 0.462389444688285 2207 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1068 loratadine 26.9 µM 0.0933531357993655 0.470696679159293 no 1566 0.462811510040601 2125 3957 A H1 histamine antagonist.
SGTC_2771 fluoxetine 41.05 µM 0.0916376821669411 0.471218024215098 no 1567 0.463492955677522 2203 3386 A selective serotonin reuptake inhibitor.
SGTC_1777 st045864 34.765 µM 0.0908786938142426 0.47144870484136 no 1568 0.463794489999243 2242 4691462
SGTC_1713 st033146 12.748 µM 0.0896253611141701 0.471829653322542 no 1569 0.464292465126296 2241 674619
SGTC_3325 9138760 55.175 µM 0.0887574242097146 0.472093476489676 no 1570 0.464637347324656 2143 43844959
SGTC_1394 3474-0001 65.7 µM 0.0865511673678644 0.47276415805183 no 1571 0.465514141479364 2186 5017666 YIL048W NEO1
SGTC_747 3448-8087 38.7 µM 0.0860673093631538 0.472911256776713 no 1572 0.46570645525761 2180 5168703
SGTC_2663 amphotericin b 100 µM 0.0831800718570369 0.473789088238225 no 1573 0.466854179086951 2223 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1647 st011722 22.4 µM 0.0828027725511401 0.473903811261425 no 1574 0.467004182261891 2234 2854783
SGTC_2888 9058547 12.99 µM 0.082463635081324 0.47400693250276 no 1575 0.467139017406302 2229 16476514
SGTC_1988 st071872 53.4 µM 0.0824014658835891 0.474025836426824 no 1576 0.467163735204717 2274 16414116
SGTC_1087 pterostilbene 9.05 µM 0.081516035641776 0.47429507746687 no 1577 0.46751578635972 2257 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1935 st074532 41.6 µM 0.0813070287651173 0.474358633856538 no 1578 0.467598892176794 2232 2829742
SGTC_1410 3909-8106 77.9 µM 0.0811212336747926 0.474415132378855 no 1579 0.467672769653391 2244 1039210
SGTC_2007 4011539 71.82 µM 0.0809224750407052 0.474475573561337 no 1580 0.467751803040851 2219 45595301
SGTC_2659 sanguinarine 24.21 µM 0.0784858167992618 0.475216592497651 no 1581 0.46872080598665 2256 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3240 9133527 49.47 µM 0.0781066161934148 0.475331920026172 no 1582 0.468871622156985 2237 17617455
SGTC_907 3448-6986 75.5 µM 0.0780000469902055 0.47536433164121 no 1583 0.468914007807536 2261 590582
SGTC_1147 3809-1045 12.3 µM 0.0770953183907262 0.475639499435731 no 1584 0.46927385865032 2155 325925
SGTC_229 benomyl 22.8748 µM 0.0760803815363408 0.475948200233733 no 1585 0.469677574081643 2178 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1683 st010134 710 nM 0.0755777147938743 0.476101095520891 no 1586 0.469877533381426 2264 3818134
SGTC_2446 5162541 200 µM 0.0743454208536637 0.476475935111561 no 1587 0.47036776819565 2249 1549321
SGTC_2934 9036370 36.88 µM 0.0722048945042347 0.477127090437308 no 1588 0.471219425046084 2250 6462800
SGTC_2280 7785178 200 µM 0.0721616775425214 0.477140237817468 no 1589 0.471236621261124 2224 2954328
SGTC_2369 9071472 200 µM 0.0715534097144362 0.477325286507832 no 1590 0.471478659321933 2232 17296037
SGTC_2288 7946289 167.31 µM 0.0708190568508707 0.477548699599423 no 1591 0.471770882365402 2265 1246052
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0702945671492906 0.477708270081994 no 1592 0.471979603299553 2204 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_36 0335-0881 14.2 µM 0.0689976898029471 0.478102846682573 no 1593 0.472495729194458 2246 23828853
SGTC_1680 diphenhydramine 100 µM 0.0666263332572452 0.478824390193446 no 1594 0.473439590706131 2133 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1913 st060213 96.1 µM 0.0654335761109294 0.479187342252827 no 1595 0.473914395740663 2272 688959
SGTC_3205 9113483 49.47 µM 0.0646853996676093 0.479415018700377 no 1596 0.474212243926155 2265 17018033
SGTC_1787 fluconazole 80 µM 0.0646197523971329 0.479434996044063 no 1597 0.47423837871968 2242 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1769 st044406 64.4 µM 0.0632168681994909 0.479861924762372 no 1598 0.474796906382321 2178 670903
SGTC_2533 agelasine 13.65 µM 0.0628967695786549 0.479959341113784 no 1599 0.474924353628021 2282 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3074 9116018 49.47 µM 0.0605136619160742 0.480684635000302 no 1600 0.475873267577681 2279 17027303
SGTC_2808 7946468 45.46 µM 0.0586362424232896 0.481256068891541 no 1601 0.476620921526533 2252 2970879
SGTC_2204 7233102 200 µM 0.0581393300837968 0.481407321579367 no 1602 0.476818823242015 2256 2172480
SGTC_1622 st003707 19.4 µM 0.0578308318023566 0.481501225192518 no 1603 0.476941689520928 2228 10140899
SGTC_1007 4101-0031 70 µM 0.0571609171268992 0.481705143659897 no 1604 0.477208505422825 2303 1146276
SGTC_2596 sinensetin 100 µM 0.0559161545315599 0.482084055449226 no 1605 0.477704300754427 2258 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2856 9022925 19.48 µM 0.0555215907183036 0.482204165987778 no 1606 0.477861464786224 2239 4944862
SGTC_3094 9117742 49.47 µM 0.0545685386740213 0.482494294506981 no 1607 0.478241101949333 2316 17149698
SGTC_191 3914-0123 66.505 µM 0.0539607461300315 0.482679323829441 no 1608 0.478483219350894 2285 3144412
SGTC_2971 9092186 9.93 µM 0.0532087485286456 0.482908258428305 no 1609 0.478782792586839 2180 25236400
SGTC_2719 novobiocin 32.65 µM 0.0522536487247527 0.483199032616982 no 1610 0.479163292892629 2302 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2114 5491910 81.25 µM 0.0516798776270697 0.483373717961857 no 1611 0.479391885568808 2289 2849228
SGTC_102 gallobenzophenone 83.616 µM 0.0500426281037358 0.48387219810731 no 1612 0.480044209271231 2320 70837
SGTC_2319 6033012 152.6 µM 0.0494362011891131 0.484056838453718 no 1613 0.480285839521053 2296 847246
SGTC_2399 5884133 200 µM 0.0473110606557446 0.484703912124079 no 1614 0.481132656413388 2281 722445
SGTC_922 1866-0035 480 µM 0.046871096203401 0.484837879842511 no 1615 0.481307982327362 2188 3156169
SGTC_2869 9037858 32.47 µM 0.0453030043189762 0.485315372442481 no 1616 0.481932896399316 2339 27187042
SGTC_1751 st044839 27.194 µM 0.0451509156281381 0.485361685416134 no 1617 0.481993508985839 2335 5291326
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0450397487197716 0.485395537302639 no 1618 0.482037813094662 2302 5282309
SGTC_1098 clofazimine 15.1 µM 0.0447826167917277 0.485473837992636 no 1619 0.482140290490797 2309 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_250 brefeldin a 552.239 µM 0.0445982077984225 0.485529993757695 no 1620 0.482213785604919 2322 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3272 9137413 49.47 µM 0.0442549152739839 0.48563453310144 no 1621 0.482350604419175 2332 17614870
SGTC_2592 piperlongumine 83.33 µM 0.0432001116658099 0.485955747747983 no 1622 0.482771008038413 2279 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1500 4488-1866 171 µM 0.0426875706610117 0.486111832880825 no 1623 0.482975293857313 2324 2900003
SGTC_1984 st072354 53.1 µM 0.0422537699700095 0.486243940732541 no 1624 0.483148199282768 2260 5762938
SGTC_2016 5121758 140 µM 0.0394394964874693 0.48710102385416 no 1625 0.48426999537431 2348 2795203
SGTC_1975 st070967 30.8 µM 0.0367757817877506 0.487912309456214 no 1626 0.485331892158158 2348 261391
SGTC_632 0781-2353 4.65 µM 0.0344973863979284 0.48860627846313 no 1627 0.486240263230865 2312 6811515 YHR007C ERG11
SGTC_1704 st028805 70.8 µM 0.0338936368380819 0.488790178436859 no 1628 0.486480983671077 2284 2876101
SGTC_3049 9092223 49.47 µM 0.0336202082902179 0.488873464588801 no 1629 0.486590003745637 2312 8623917
SGTC_2645 abamectin 100 µM 0.0331568644255342 0.489014599924435 no 1630 0.486774748197231 2334 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1871 st057448 67.3 µM 0.0327981950869153 0.489123852165424 no 1631 0.486917758775927 2342 691747
SGTC_1123 mangostin 811.285 nM 0.0319088471773424 0.489394754911017 no 1632 0.487272371603238 2251 5281650 An antioxidant.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0306506912895888 0.489778007951243 no 1633 0.487774057658253 2355 97141
SGTC_382 3229-0966 23.2 µM 0.0302770302583902 0.489891832505682 no 1634 0.487923057685726 2340 5722370
SGTC_1609 st001574 46.4 µM 0.0297726651376194 0.490045473419587 no 1635 0.488124179579759 2352 3960012
SGTC_1840 st055363 71 µM 0.0278428395497334 0.490633354962844 no 1636 0.488893749087229 2264 676033
SGTC_2182 6325192 200 µM 0.0263384708415897 0.491091644025486 no 1637 0.489493685125663 2363 736248
SGTC_2153 5569715 200 µM 0.0248695307997283 0.491539151494642 no 1638 0.490079515306769 2363 2054701
SGTC_1572 epiandrosterone 68.9 µM 0.0247833556149375 0.491565404800834 no 1639 0.49011388363836 2329 441302 A steroid.
SGTC_2917 7979103 53.79 µM 0.023794561551149 0.491866643913566 no 1640 0.490508239038121 2344 2980565
SGTC_2879 9041815 71.43 µM 0.0234801365914062 0.491962435412139 no 1641 0.490633641410491 2365 4942971
SGTC_1813 st051246 8.6015 µM 0.023472493891498 0.491964763813483 no 1642 0.490636689566529 2366 5291959
SGTC_3135 9127742 49.47 µM 0.0231007424076425 0.492078020801137 no 1643 0.490784956744768 2298 3643468
SGTC_84 0443-0269 128.823 µM 0.021689660239011 0.492507923719725 no 1644 0.491347755884018 2367 6150058
SGTC_1852 st056254 31.4 µM 0.018723301062443 0.493411688002294 no 1645 0.492530919975998 2307 442583
SGTC_1819 st053448 58.6 µM 0.0181003618495778 0.493601484106965 no 1646 0.492779394642642 2348 2857616
SGTC_198 3454-2873 16.191 µM 0.0178310502863957 0.49368353796634 no 1647 0.492886817073886 2354 710957
SGTC_1120 ficusin 1.78878 µM 0.0164030220413288 0.494118634059825 no 1648 0.493456434417019 2340 6199 A DNA cross-linker.
SGTC_1559 coumarin 343 70.1 µM 0.0158841440540075 0.494276729181344 no 1649 0.493663409809978 2365 108770 A hepatotoxic, DNA x-linker.
SGTC_386 1509-0011 3.07 µM 0.0157868331317593 0.494306378607187 no 1650 0.493702226384013 2368 3107280
SGTC_1924 st058459 75.1 µM 0.0154795794006958 0.494399995197363 no 1651 0.493824787909905 2382 688683
SGTC_172 1112-0046 2.638 µM 0.0150347399675597 0.49453553307433 no 1652 0.494002232512249 2366 2802135 YIL048W NEO1
SGTC_2875 9039966 71.43 µM 0.0121064735184994 0.495427759950739 no 1653 0.495170333825238 2352 6463691
SGTC_446 go6976 132 µM 0.0114483758797223 0.495628282032017 no 1654 0.495432858585503 2374 3501 A protein kinase C inhibitor.
SGTC_1477 0139-0234 16 µM 0.0111406174469074 0.495722056282721 no 1655 0.49555562860515 2379 620880
SGTC_988 1497-1057 103 µM 0.0110953163573386 0.49573585958251 no 1656 0.495573700008195 2385 3533044
SGTC_3279 9140807 49.47 µM 0.0110897423605951 0.495737557986783 no 1657 0.495575923574365 2382 45595718
SGTC_650 1328-0195 38 µM 0.010312123561862 0.495974500219446 no 1658 0.49588613082198 2389 2780821
SGTC_1746 st038117 42 µM 0.00830537506033485 0.496585967451068 no 1659 0.496686672825691 2377 2898218
SGTC_444 curcumin 90.4 µM 0.00789425347782623 0.496711239480215 no 1660 0.496850681226047 2382 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2122 5258151 111.688 µM 0.00785150526454009 0.496724265220988 no 1661 0.496867734767221 2381 2173356
SGTC_2994 9053520 71.4286 µM 0.006796350520984 0.497045780834003 no 1662 0.497288669297667 2392 4647384
SGTC_296 1222-0039 74.9 µM 0.00651651279134549 0.497131050362936 no 1663 0.497400305926077 2396 5984176
SGTC_2656 pseudo-anisatin 100 µM 0.00561831405822886 0.497404741924598 no 1664 0.497758628769255 2396 6708809 A neurotoxin.
SGTC_3347 9188721 44.724 µM 0.00547543250878333 0.497448279704263 no 1665 0.497815629383471 2388 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2427 5545055 42.75 µM 0.0044477564605993 0.497761426201898 no 1666 0.49822560774527 2387 5372858
SGTC_711 k292-0785 179 µM 0.0039456494615047 0.49791442536563 no 1667 0.498425917690422 2398 4146315
SGTC_2099 5377090 177.372 µM 0.00322430124986318 0.498134230984846 no 1668 0.498713692135447 2394 2243829
SGTC_844 0330-0132 15.3 µM 0.00287267473236633 0.498241377068066 no 1669 0.498853970167641 2402 2828079
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.00283950651653363 0.49825148394733 no 1670 0.498867202317333 2375 61125 An anti-inflammatory.
SGTC_2526 patulin 37.61 µM 0.00259582920864146 0.498325736305974 no 1671 0.498964415138991 2393 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_821 1114-0266 29.2 µM 0.00233503315725359 0.498405205082733 no 1672 0.499068457393953 2397 3123235
SGTC_3277 9138724 49.47 µM 0.00233055332351667 0.498406570161122 no 1673 0.499070244584177 2397 15943418
SGTC_2068 5226020 147 µM 0.00205620865102241 0.498490167491313 no 1674 0.499179692009823 2401 1810509
SGTC_1495 4469-0029 237 µM 0.00204750802858301 0.498492818715057 no 1675 0.499183163048673 2403 793680
SGTC_3011 9081274 71.4286 µM 0.000988652022015923 0.498815470137284 no 1676 0.499605584972066 2401 6625322
SGTC_1018 4259-0013 28.1 µM 0.0007299064060101 0.498894314450178 no 1677 0.499708809499763 2392 6801262
SGTC_2942 9052777 62.25 µM -0.002243351511159 0.499800320446101 no 1678 0.499105032983069 2412 6469503
SGTC_975 1335-0046 28.5 µM -0.00355393426636391 0.499800320446101 no 1679 0.49858218834398 2414 16486740
SGTC_2252 omeprazole 400 µM -0.00372173466306474 0.499749188529005 no 1680 0.498515246114099 2430 4594 A proton pump inhibitor.
SGTC_1386 3228-0095 33.8 µM -0.00478851318707468 0.499424121305889 no 1681 0.49808966693003 2408 870181
SGTC_1428 4049-0204 61.7 µM -0.00597744676434398 0.499061831630228 no 1682 0.497615357957355 2419 X1428
SGTC_1021 4476-0760 85.3 µM -0.00633973117444331 0.498951437124218 no 1683 0.497470830130293 2418 746768
SGTC_1516 st013856 110 µM -0.00642251737907075 0.498926210705589 no 1684 0.497437803885444 2457 5281404 A mutagen and neurotoxin.
SGTC_1434 4073-0095 163 µM -0.00715616234211202 0.498702656327688 no 1685 0.497145128642977 2419 24133745
SGTC_1320 1313-0481 95.3 µM -0.00730772682373392 0.49865647204298 no 1686 0.497084664744291 2413 6813365 YLR208W SEC13
SGTC_600 1495-0418 41.6 µM -0.008891281469774 0.498173937104979 no 1687 0.496452938630241 2426 5377768
SGTC_581 0958-0271 211 µM -0.00985234206159775 0.497881087519503 no 1688 0.496069547778032 2418 4591145
SGTC_2926 9010726 65.15 µM -0.0102888780114078 0.49774806883189 no 1689 0.495895403962932 2441 2994293
SGTC_1338 1486-1223 76 µM -0.0111489961961392 0.497485979383704 no 1690 0.495552286175407 2457 3444526
SGTC_2285 7945142 200 µM -0.0117075001791314 0.497315796367418 no 1691 0.495329489875329 2437 2970608
SGTC_1432 4049-0298 68.4 µM -0.0150116209865283 0.49630900124804 no 1692 0.494011454610508 2441 741646
SGTC_2063 5246145 200 µM -0.0152451367807876 0.496237847714255 no 1693 0.493918305947225 2452 711240
SGTC_1630 st005209 31.3 µM -0.0159222451969226 0.496031529778402 no 1694 0.493648211575165 2425 3367314
SGTC_1848 st056003 16.4 µM -0.0159504237064116 0.496022943684276 no 1695 0.493636971403737 2424 146492
SGTC_717 1532-0246 73.2 µM -0.0163858303126921 0.495890273947468 no 1696 0.493463292002802 2446 9561992
SGTC_1413 3910-0535 34.4 µM -0.0188637567021124 0.495135251219499 no 1697 0.492474896177444 2463 2876951
SGTC_981 1488-1094 54.9 µM -0.0197391613472911 0.494868519960051 no 1698 0.492125725310388 2438 3449522
SGTC_3165 9101544 49.47 µM -0.0200076404610453 0.494786716219386 no 1699 0.492018638789938 2447 5002184
SGTC_2000 st075254 36.4 µM -0.0211739415443017 0.494431354884645 no 1700 0.491553450628358 2453 17234175
SGTC_702 1488-0190 94 µM -0.0220964153480164 0.494150288620701 no 1701 0.491185522958579 2449 949357
SGTC_85 0868-0259 160.055 µM -0.0223759904618022 0.494065106137094 no 1702 0.491074016196101 2506 83173
SGTC_764 1951-2361 146 µM -0.023347981681016 0.493768956636399 no 1703 0.490686349142122 2443 5438930
SGTC_1132 3456-3614 2.5 µM -0.0245230954497043 0.493410923686151 no 1704 0.490217680874069 2472 3125502
SGTC_883 0850-0245 24.6 µM -0.024982754407463 0.493270876501993 no 1705 0.490034359652595 2565 6823229 YPR165W RHO1
SGTC_535 2293-4129 48.2 µM -0.0255793073434318 0.493089122208212 no 1706 0.489796445508711 2448 396118 YIL048W NEO1
SGTC_2239 6685329 187.64 µM -0.0259299534763184 0.492982290042179 no 1707 0.489656604327648 2550 805680
SGTC_2214 7179297 48.276 µM -0.0295543157267928 0.491878078122458 no 1708 0.488211250075387 2453 769744
SGTC_3125 9127534 49.47 µM -0.0302009618965712 0.491681074752099 no 1709 0.487953390700072 2461 1639235
SGTC_2866 9034245 58.44 µM -0.0303973262057768 0.491621251970737 no 1710 0.487875088625289 2509 6462273
SGTC_2137 5261020 140 µM -0.0320529300692187 0.491116876552506 no 1711 0.487214920233326 2459 763655
SGTC_2282 7944268 200 µM -0.0330045650041571 0.490826969817034 no 1712 0.4868354736396 2491 2970414
SGTC_427 1354-0053 47.3 µM -0.0332416736507738 0.49075473762039 no 1713 0.486740932852154 2652 6813657
SGTC_69 0096-0274 206.684 µM -0.0336434578220572 0.490632339769163 no 1714 0.486580733768506 2679 6741392
SGTC_1806 st050005 60.3 µM -0.035048254393264 0.490204395420298 no 1715 0.486020631523262 2477 5194765
SGTC_2673 kobusone 100 µM -0.0358126168816912 0.489971551744521 no 1716 0.485715886352239 2481 6710676 An epoxy ketone and protein crosslinker.
SGTC_2035 5154463 94.595 µM -0.0371539086134388 0.48956296949325 no 1717 0.485181144406972 2474 2769623
SGTC_2891 9063876 19.48 µM -0.037464521247944 0.489468352690194 no 1718 0.485057314109232 2470 6472478
SGTC_3152 9099253 49.47 µM -0.0378264090369229 0.489358117530521 no 1719 0.484913044034869 2511 25236131
SGTC_2718 lomofungin 53.02 µM -0.0387724960123996 0.489069932478721 no 1720 0.484535886671208 2493 5351222 A RNA synthesis inhibitor.
SGTC_1488 4013-0813 75.9 µM -0.0396990980253189 0.488787688220062 no 1721 0.484166510391549 2475 2910057
SGTC_2534 helenine 20.12 µM -0.0397419704713252 0.488774629348349 no 1722 0.484149420247232 2483 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3192 9110362 49.47 µM -0.0398335647422991 0.48874672993471 no 1723 0.484112908331745 2472 16649480
SGTC_1315 1237-0019 3.69 µM -0.0404492657979069 0.488559190182236 no 1724 0.48386747696798 2477 825140
SGTC_2855 9016525 58.44 µM -0.0406817451874346 0.488488378668956 no 1725 0.483774807388447 2473 43811474
SGTC_3327 9140648 26.9345 µM -0.0419148015352263 0.488112804888709 no 1726 0.483283308424457 2485 8029710
SGTC_2805 7950783 58.44 µM -0.0425953768481176 0.487905514522151 no 1727 0.483012040443991 2520 1178958 YDL195W SEC31
SGTC_3082 9117008 49.47 µM -0.0426733907225221 0.487881753179389 no 1728 0.482980945684215 2516 41448529
SGTC_286 k060-0067 22.9 µM -0.0431457033938677 0.487737897852837 no 1729 0.482792693579232 2494 5985051
SGTC_130 0136-0219 337.655 µM -0.0437070292138952 0.487566933291855 no 1730 0.482568968035295 2472 234244
SGTC_2469 5655019 90.81 µM -0.044721166724418 0.487258060433356 no 1731 0.482164780984548 2595 2788239
SGTC_926 2268-1401 59.4 µM -0.0447903559944156 0.487236987938688 no 1732 0.48213720609057 2479 2931578
SGTC_1359 1582-0056 520 nM -0.0451710374346872 0.487121047079487 no 1733 0.481985489728313 2526 3661189
SGTC_1843 st055809 45.5 µM -0.0455892412763794 0.48699367960158 no 1734 0.481818822237569 2583 16413835
SGTC_2371 9071574 200 µM -0.0459070559321384 0.486896887376404 no 1735 0.481692165143839 2473 45596039
SGTC_1783 st039459 87.517 µM -0.0471420828110675 0.486520760435126 no 1736 0.481199993685303 2583 729761
SGTC_2927 9011802 47.9 µM -0.047626078142638 0.486373363102456 no 1737 0.481007124127776 2530 43912568
SGTC_254 nsc-64875 3.808 µM -0.0487901218472334 0.486018869540254 no 1738 0.48054327721218 2551 56993
SGTC_2420 aureobasidin a 50 nM -0.0527191571504412 0.484822418883931 no 1739 0.478977837525728 2654 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_132 0417-1715 25.805 µM -0.0527252944825807 0.484820550077574 no 1740 0.478975392484969 2508 6769098
SGTC_1865 st057639 52.2 µM -0.052879055875215 0.484773730125043 no 1741 0.478914136017613 2493 688818
SGTC_1600 coumarin 106 71.1 µM -0.0538214375030032 0.484486781928975 no 1742 0.478538714807323 2648 100336 A hepatotoxic, DNA x-linker.
SGTC_1189 1431-2119 7.28 µM -0.0540090440719705 0.484429658078299 no 1743 0.478463979316516 2495 3107275
SGTC_1449 4112-4002 201 µM -0.0562746812917532 0.48373982549331 no 1744 0.477561494133246 2547 2059539
SGTC_100 0086-0128 49.5915 µM -0.0564255694715732 0.483693885341191 no 1745 0.477501393953697 2499 93297
SGTC_1690 st023502 41.2 µM -0.0566157319756554 0.483635987844898 no 1746 0.4774256511708 2514 24207482
SGTC_3354 9151612 71.43 µM -0.0582355075301208 0.483142839806452 no 1747 0.476780518892157 2541 27261949
SGTC_441 propafenone 146 µM -0.0594156273161891 0.48278356316279 no 1748 0.476310533125188 2501 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1176 0848-0131 83.3 µM -0.0598912408401301 0.482638770924272 no 1749 0.476121128085092 2552 6769040
SGTC_2620 irigenin 100 µM -0.0605990365444751 0.482423299117286 no 1750 0.475839270420931 2566 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2199 6590217 200 µM -0.0614420985238107 0.482166655368999 no 1751 0.47550356294947 2535 703109
SGTC_1385 3091-4834 14.1 µM -0.0614486628095951 0.48216465710716 no 1752 0.475500949117297 2570 4072814
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0614925416773191 0.482151299768034 no 1753 0.475483477023283 2660 94937 An inhibitor of serotonin biosynthesis.
SGTC_557 1315-0110 16.2 µM -0.0622011644798179 0.481935587891802 no 1754 0.475201317583379 2521 6833801
SGTC_596 1155-0152 116 µM -0.0622556960202108 0.481918988163247 no 1755 0.475179604727217 2524 280313
SGTC_67 0335-0847 266 µM -0.0623836249875076 0.481880045940006 no 1756 0.475128667462957 2755 4552207 YOR254C SEC63
SGTC_2166 5933061 31.504 µM -0.0641406734625884 0.481345209170872 no 1757 0.474429107882394 2737 2877375
SGTC_2707 st078556 66.6 µM -0.0644425367468772 0.481253326849623 no 1758 0.474308930483937 2535 17250899
SGTC_1719 st032227 49.2 µM -0.0651098293754289 0.481050217263351 no 1759 0.474043277165511 2547 3125804
SGTC_1782 st039423 80.636 µM -0.0667598101772425 0.480548019671442 no 1760 0.473386459413905 2562 2068169
SGTC_2646 retinol 96.75 µM -0.0676516824641898 0.480276577124935 no 1761 0.473031456472925 2587 445354 A vitamin A analog and teratogen.
SGTC_357 1325-0123 420 µM -0.0697504898704036 0.479637838537322 no 1762 0.472196127250838 2525 1098503
SGTC_1887 st057648 70.8 µM -0.0727006239942753 0.478740101000872 no 1763 0.471022175994718 2590 688672
SGTC_148 3253-0744 288.01 µM -0.0729787563100274 0.478655469724344 no 1764 0.470911511217169 2520 6893655
SGTC_74 000s-0487 160.283 µM -0.075729394282618 0.477818546407149 no 1765 0.469817194939998 2527 677548
SGTC_1730 st033808 45.1 µM -0.0776163442056243 0.477244469618444 no 1766 0.469066620403447 2563 1045166
SGTC_2698 st077697 67.5 µM -0.0781041572993769 0.477096067285768 no 1767 0.468872600126198 2584 3154499
SGTC_1705 st027868 56.3335 µM -0.0794508166802396 0.476686403578977 no 1768 0.468337025243279 2627 292948
SGTC_1258 0671-0043 57.1 µM -0.0808272643376075 0.476267703523927 no 1769 0.467789662598321 2601 4298767
SGTC_63 0099-0242 26.702 µM -0.0810514099802883 0.476199523383149 no 1770 0.467700533852413 2550 3898502 YLR359W ADE13
SGTC_283 0987-0079 11.7 µM -0.0811092442325794 0.476181931597357 no 1771 0.467677537039041 2555 411556
SGTC_161 4065-0411 162.148 µM -0.0815418900599543 0.476050332638017 no 1772 0.467505506162104 2626 1906281 YLR208W SEC13
SGTC_646 4092-0839 27.3 µM -0.0822525904970695 0.475834162791946 no 1773 0.467222926957438 2615 877796
SGTC_500 h-89 112 µM -0.0823817812840908 0.475794868302372 no 1774 0.467171561614277 2672 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_954 1189-0853 2.85 µM -0.0825752353375504 0.475736028027611 no 1775 0.467094646673384 2525 2828194
SGTC_2135 5326629 150.42 µM -0.084122583799266 0.475265411348969 no 1776 0.46647948450434 2582 5020077
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0846042324932613 0.475118927822465 no 1777 0.466288017046246 2540 66535 A nucleotide analog.
SGTC_2551 apiole 73.87 µM -0.085807938368122 0.474752860229643 no 1778 0.465809547925957 2546 10659 A possible DNA adduct former.
SGTC_2050 5263056 171 µM -0.0862736942558763 0.474611221581307 no 1779 0.465624424717024 2600 763468 YGL055W OLE1
SGTC_718 1130-0073 349 µM -0.0869637878830579 0.474401366631563 no 1780 0.465350148051841 2635 6740020
SGTC_1284 0929-0043 16 µM -0.0869749060263604 0.474397985702802 no 1781 0.465345729297032 2626 1239883
SGTC_490 phenamil 164 µM -0.0886008560529758 0.473903568700132 no 1782 0.464699563865374 2655 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_379 3970-0972 5.9 µM -0.0890381802893826 0.473770594479922 no 1783 0.464525783560599 2601 2898042 YBL034C STU1
SGTC_3089 9117425 49.47 µM -0.0890953093715158 0.473753223842143 no 1784 0.464503082575262 2620 9401657
SGTC_124 0136-0217 7.121 µM -0.0894896883572308 0.47363331054443 no 1785 0.464346374101405 2579 3976905
SGTC_80 0159-0065 512.242 µM -0.0895909622403859 0.473602517997486 no 1786 0.464306133305979 2546 1548079
SGTC_1736 st036774 51 µM -0.0896331734446783 0.473589683634529 no 1787 0.464289360950972 2715 1272247
SGTC_1758 st042942 75.2445 µM -0.0933655963503712 0.472454946267638 no 1788 0.462806560616554 2555 669317
SGTC_2776 terbinafine 19.92 µM -0.0936596696741094 0.472365550990135 no 1789 0.462689754166298 2549 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3084 9116877 49.47 µM -0.0939475721395739 0.472278032938803 no 1790 0.462575401908497 2555 27241325
SGTC_368 fentichlor 4.58 µM -0.0940417331769356 0.472249409679449 no 1791 0.462538002666044 2647 7329 A pesticide.
SGTC_802 4112-3352 742 µM -0.0944879062124034 0.472113783063942 no 1792 0.462360794454234 2721 704594
SGTC_2974 9094440 9.66 µM -0.0948887440186898 0.471991940100174 no 1793 0.462201598574328 2792 25236134
SGTC_209 4077-0173 175.592 µM -0.0958846392494444 0.471689228462338 no 1794 0.461806097233496 2653 15993494
SGTC_968 1309-0633 340 µM -0.097612135886188 0.471164178647263 no 1795 0.461120143743138 2573 3761976
SGTC_2933 9026794 32.47 µM -0.0991322359319275 0.470702205713209 no 1796 0.460516638783151 2631 17586027
SGTC_2822 7994718 71.43 µM -0.0997665494716249 0.470509443387979 no 1797 0.460264832585765 2569 1018011
SGTC_1741 st038134 10.228 µM -0.10096358775523 0.47014569280564 no 1798 0.459789682595959 2691 1272587
SGTC_2045 5106652 78.05 µM -0.10098340049039 0.470139672409978 no 1799 0.45978181864958 2656 673349
SGTC_801 0866-0028 10.1 µM -0.100993218137058 0.470136689173851 no 1800 0.459777921896767 2575 6849771
SGTC_1148 3909-7663 27.7 µM -0.101350182777458 0.470028221365073 no 1801 0.459636240573192 2733 4084526
SGTC_3257 9139206 32.98 µM -0.101481008266079 0.469988469093169 no 1802 0.459584316465153 2649 4910041
SGTC_638 3970-0837 4.09 µM -0.102904556080056 0.469555933202264 no 1803 0.459019360835737 2619 4118451 YLR208W SEC13
SGTC_1155 4088-0394 48.2 µM -0.103679672063028 0.469320434245403 no 1804 0.458711779522612 2578 2326248
SGTC_3215 9129942 49.47 µM -0.103813338594826 0.469279824207312 no 1805 0.458658740499539 2631 17682944
SGTC_3073 9114972 49.47 µM -0.104091070055255 0.469195445953609 no 1806 0.458548538712778 2614 41905075
SGTC_1689 st020265 53.493 µM -0.105111829759928 0.468885338442343 no 1807 0.458143536257403 2618 5758320 YPR016C TIF6
SGTC_803 4488-1585 147 µM -0.105746683825254 0.468692478842536 no 1808 0.457891669819121 2651 747204
SGTC_1332 1480-0653 17.5 µM -0.106542785106219 0.468450645028899 no 1809 0.457575855480945 2560 5749438
SGTC_760 0568-0725 82.9 µM -0.107612286968856 0.46812577793043 no 1810 0.457151625001798 2722 3916171
SGTC_2211 7117706 200 µM -0.108581544453003 0.467831378944237 no 1811 0.456767199792971 2593 822771
SGTC_2748 diazoxide 86.69 µM -0.109562484089898 0.467533449573751 no 1812 0.456378182421062 2687 3019 A potassium channel activatior.
SGTC_1531 st059297 52.4 µM -0.109809979717701 0.467458283475914 no 1813 0.456280038120935 2698 7566702
SGTC_2376 9072922 81.32 µM -0.109942420277343 0.46741806085769 no 1814 0.456227519960927 2732 17087968
SGTC_2430 5571206 200 µM -0.110033463892377 0.467390410815834 no 1815 0.456191417845217 2652 1731771
SGTC_449 xestospongin c 11.1929 µM -0.110339157964664 0.467297572355712 no 1816 0.456070201637774 2699 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_47 0149-0135 24.25 µM -0.1129533214238 0.46650373117656 no 1817 0.455033781199857 2561 5239155
SGTC_2625 euphol 100 µM -0.113722538475307 0.466270168804759 no 1818 0.454728872654429 2687 6708538 A triterpene alcohol.
SGTC_696 1560-0013 611 µM -0.113841589145869 0.466234021712045 no 1819 0.454681684754952 2742 1650269
SGTC_1246 0422-0085 105 µM -0.114531119068407 0.466024666749248 no 1820 0.454408389623389 2637 264295
SGTC_1143 3454-2408 5.08 µM -0.114867423917355 0.465922561333109 no 1821 0.454275103044599 2586 X1143
SGTC_2520 obtusaquinone 4.71 µM -0.115047302713276 0.46586794930518 no 1822 0.454203814394054 2729 5967872
SGTC_2636 apigenin dimethyl ether 100 µM -0.116906879556092 0.465303411096851 no 1823 0.453466923221323 2720 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2313 7726885 200 µM -0.117798982360482 0.465032607464982 no 1824 0.453113467946477 2708 726423
SGTC_1197 1601-0112 267 µM -0.117848028323726 0.465017719711052 no 1825 0.453094036782625 2599 7350313
SGTC_1998 st075797 76.8 µM -0.119714916543496 0.464451068030446 no 1826 0.452354491825167 2584 24208315
SGTC_2075 5212009 200 µM -0.12146758493032 0.463919150785712 no 1827 0.451660344019804 2699 780898
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.123095724195059 0.463425084634427 no 1828 0.451015648564592 2611 15053
SGTC_1681 tripelennamine 100 µM -0.124215030353497 0.463085458840366 no 1829 0.450572510951806 2614 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_555 4296-0685 37 µM -0.125003083504697 0.46284635971054 no 1830 0.450260554602756 2603 2908540 YHR072W ERG7
SGTC_976 1348-1067 47.6 µM -0.126625563193437 0.462354133902205 no 1831 0.449618381648301 2624 5310671 YGL099W LSG1
SGTC_456 gingerol 170 µM -0.127269281177063 0.462158859495914 no 1832 0.449363636317756 2783 442793 A herb.
SGTC_1914 st062367 72.6 µM -0.128078548337308 0.46191337803598 no 1833 0.449043406082136 2668 978205
SGTC_1418 3966-3099 2.4 µM -0.130150654183056 0.461284896000861 no 1834 0.448223617330856 2658 740335
SGTC_1288 0973-0013 65.5 µM -0.130258789963698 0.461252100415702 no 1835 0.448180841531925 2725 4315430
SGTC_1527 coumarin 137 µM -0.130630793235323 0.461139280707671 no 1836 0.448033690985476 2866 323 A hepatotoxic, DNA x-linker.
SGTC_2273 7815444 169.05 µM -0.131011416769586 0.461023849917024 no 1837 0.447883137987579 2676 2824616
SGTC_2988 9073640 71.4286 µM -0.132303586829095 0.460632001142705 no 1838 0.447372085218982 2790 9102229
SGTC_113 0099-0221 2.5 µM -0.132394470716774 0.460604442164502 no 1839 0.447336143954425 2643 89219
SGTC_1186 1319-0216 26 µM -0.133125683884725 0.460382721225235 no 1840 0.447046991563172 2807 4565136
SGTC_2849 9019321 12.99 µM -0.136075388227093 0.459488427627932 no 1841 0.445880841940436 2744 16489627
SGTC_3260 9137109 49.47 µM -0.136131125684584 0.459471531062003 no 1842 0.445858810912385 2675 17478346
SGTC_2108 5365811 200 µM -0.139833259954939 0.458349410673698 no 1843 0.444395866907695 2741 780283
SGTC_1870 st057514 26.5 µM -0.140375146624957 0.458185191941282 no 1844 0.444181796762076 2635 5393161
SGTC_2564 betulinic acid 100 µM -0.141170716167566 0.45794410756414 no 1845 0.443867539739037 2835 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3028 9087778 49.47 µM -0.141254842432444 0.457918615374349 no 1846 0.443834311178424 2666 17217395
SGTC_3345 9148410 3.559 µM -0.143230909239307 0.457319871774563 no 1847 0.443053909720908 2733 4903596
SGTC_3217 9129673 49.47 µM -0.144217985141312 0.457020826286578 no 1848 0.442664169659818 2802 17248312
SGTC_3079 9117512 49.47 µM -0.146369801319903 0.456368994518585 no 1849 0.441814732794109 2624 7185044
SGTC_2155 5570423 76 µM -0.147324482962432 0.456079838245283 no 1850 0.441437954357132 2676 797402
SGTC_1658 st012944 20 µM -0.147333740596063 0.456077034384552 no 1851 0.441434300961659 2728 24207260
SGTC_3298 9116858 71.43 µM -0.150434233491547 0.455138111591744 no 1852 0.440211017076505 2785 2506942
SGTC_2041 5107442 45.335 µM -0.150508797352847 0.45511553446915 no 1853 0.440181605257958 2753 793005
SGTC_1092 toremifene 6.32 µM -0.151794649073832 0.454726215484391 no 1854 0.439674451324696 2661 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3092 9117248 49.47 µM -0.151903571021655 0.454693239038254 no 1855 0.439631495857136 2676 17141857
SGTC_2347 9049783 174.81 µM -0.152339696278959 0.454561203939921 no 1856 0.439459508588791 2801 6467988 YPL169C MEX67
SGTC_1972 st070201 17.4 µM -0.15307702359642 0.454337992603312 no 1857 0.439168767413891 2766 2829099
SGTC_1066 ketoconazole 628 nM -0.153771896139773 0.454127646810878 no 1858 0.43889479693684 2839 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2418 pentamidine 31.67 µM -0.15478606658559 0.453820669032336 no 1859 0.438494988035835 2645 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_204 PMA1.184 62.41 µM -0.157723709787798 0.452931634411667 no 1860 0.437337258316484 2645 2252213 YGL008C PMA1
SGTC_3115 9123671 49.47 µM -0.15864868920829 0.452651751578291 no 1861 0.436972833055785 2659 3286988
SGTC_1377 2944-0135 198 µM -0.158740024286696 0.45262411643126 no 1862 0.436936851572922 2766 1894137
SGTC_3202 9113761 49.47 µM -0.159038317309708 0.452533863862161 no 1863 0.436819342578261 2879 4798415
SGTC_3128 9127691 49.47 µM -0.160432910288589 0.452111943595141 no 1864 0.436270033352915 2853 41316314
SGTC_349 k015-0014 24 µM -0.162287528619037 0.451550931077548 no 1865 0.435539717607138 2691 2196908
SGTC_2294 7971431 200 µM -0.163020787507465 0.451329150655234 no 1866 0.435251033773743 2814 5741572
SGTC_3256 9138902 49.47 µM -0.1645140965034 0.450877533622145 no 1867 0.434663225265805 2676 17228773
SGTC_487 nimodipine 119 µM -0.164630419291899 0.450842357126399 no 1868 0.434617443383117 2742 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1874 staurosporine 7.6 µM -0.164998497735744 0.450731051216923 no 1869 0.434472582241943 2814 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1029 k015-0030 64.7 µM -0.166325530041801 0.450329792523157 no 1870 0.433950387898923 2809 2208316
SGTC_261 5-fluorouridine 15.376 µM -0.170651161934996 0.449022192944869 no 1871 0.432249033260098 2915 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.170996771914353 0.448917741850259 no 1872 0.432113151926184 2696 23665772 A membrane-active detergent.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.171529592766891 0.448756718365635 no 1873 0.431903681791791 2717 65057 A dermal irritant. YDR527W RBA50
SGTC_1430 4049-0248 69.1 µM -0.171778187228384 0.448681593661959 no 1874 0.431805957336735 2826 22774488
SGTC_1602 st001878 87.6 µM -0.17188778396546 0.448648474351483 no 1875 0.431762875314968 2903 595405 YLR310C CDC25
SGTC_3225 9130819 49.47 µM -0.173351010700344 0.448206332599428 no 1876 0.43118776491604 2739 4547121
SGTC_425 3825-7017 13.1 µM -0.1743243177399 0.447912264983856 no 1877 0.430805294520175 2973 3397440
SGTC_1631 benzylvanillin 81.9 µM -0.175198750877194 0.447648094785472 no 1878 0.430461732904272 2860 75506
SGTC_903 1134-0042 114 µM -0.176815277078873 0.447159796147832 no 1879 0.429826744376181 2724 701009
SGTC_822 1487-0950 154 µM -0.178331759827957 0.446701790090071 no 1880 0.429231218912321 2774 1958375
SGTC_2333 9017922 200 µM -0.178890797359385 0.446532968234934 no 1881 0.429011724435211 2856 3163164
SGTC_3231 9132313 49.47 µM -0.17937504962579 0.446386738360566 no 1882 0.428821610578656 2775 4905967
SGTC_202 3594-0513 34.79 µM -0.180893759445201 0.44592818025141 no 1883 0.428225483643793 2709 708429
SGTC_1701 st028638 40.4 µM -0.182624538347096 0.445405678361562 no 1884 0.427546314658428 2817 3490878
SGTC_993 3909-8757 62.7 µM -0.182746607659587 0.445368830634011 no 1885 0.427498421940061 2778 4288324 YLR208W SEC13
SGTC_11 0438-0307 1.3 µM -0.18299721267676 0.445293184719225 no 1886 0.427400102825512 2837 4011476
SGTC_1450 4112-4260 37.6 µM -0.183550278220751 0.445126247193003 no 1887 0.427183136243771 2743 1633175
SGTC_37 0566-0070 1.56 µM -0.183833351449644 0.445040808018626 no 1888 0.427072095660932 2841 1626686
SGTC_392 N-ethylmaleimide 8.33 µM -0.183986064151986 0.444994716245042 no 1889 0.427012193746249 2777 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1446 4239-0190 62 µM -0.185872804401982 0.444425321525476 no 1890 0.42627225473968 2753 1340085
SGTC_3111 9122088 49.47 µM -0.186388316125727 0.444269766401816 no 1891 0.42607012713404 2797 16876704
SGTC_1483 3453-0561 55.9 µM -0.187683841007171 0.443878881069642 no 1892 0.425562249084988 2831 4546991
SGTC_1744 st037937 38.9 µM -0.190175503714117 0.443127251218722 no 1893 0.424585803008871 2914 1016152
SGTC_923 1900-2434 73.3 µM -0.192032303398801 0.442567265736943 no 1894 0.423858450921131 2723 5910570
SGTC_189 3970-0742 2.116 µM -0.192236298368 0.442505750608385 no 1895 0.423778557061185 2761 2891807
SGTC_2568 diosmetin 100 µM -0.192251380780733 0.442501202528894 no 1896 0.423772650215492 2794 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1001 4048-4355 44.4 µM -0.193855952344738 0.442017389727171 no 1897 0.423144337142546 2750 21824233
SGTC_2440 5628896 157.78 µM -0.195217717308909 0.441606856144099 no 1898 0.422611254743244 2772 5522048
SGTC_556 4058-0063 51.5 µM -0.195570100412627 0.441500632812552 no 1899 0.422473332369388 2755 6615692
SGTC_584 0986-0246 15.4 µM -0.196103908989633 0.4413397281045 no 1900 0.422264418367338 2733 53315 YDR232W HEM1
SGTC_2694 st077685 81.9 µM -0.19650688336844 0.441218266863396 no 1901 0.422106722775654 2732 2838096
SGTC_2956 9076196 2.52 µM -0.197345117131271 0.440965631022531 no 1902 0.421778737561454 2858 16423868
SGTC_1696 st025591 34.7925 µM -0.197908338953238 0.440795894703594 no 1903 0.421558389841741 2775 2787147
SGTC_2724 maprotiline 69.64 µM -0.202302637546676 0.439471975151168 no 1904 0.419840069071294 2794 4011 A tricyclic antidepressant.
SGTC_2871 9038510 12.99 µM -0.202950441688551 0.439276860818633 no 1905 0.419586883907632 2792 4945164
SGTC_2782 7736369 71.43 µM -0.203169174867365 0.439210983157676 no 1906 0.41950140262397 2822 2950836 YOL077C BRX1
SGTC_504 lovastatin 124 µM -0.20529464838595 0.438570924847604 no 1907 0.418670962493134 2779 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1441 4106-0040 13 µM -0.205560345846528 0.438490924823017 no 1908 0.418567177692472 2759 2904180
SGTC_894 0960-0238 55.9 µM -0.206836943904732 0.438106583365261 no 1909 0.418068601454251 2760 6741907 YDL195W SEC31
SGTC_2607 solasodine 47.35 µM -0.207926062963104 0.437778731764555 no 1910 0.417643349289995 2808 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_409 arachidonic acid 100 µM -0.208322206710453 0.437659493342371 no 1911 0.417488696772675 2775 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2825 7998094 58.44 µM -0.209003076901012 0.437454566100898 no 1912 0.41722291832152 2853 2987815
SGTC_1404 3909-7820 48.3 µM -0.209388084631802 0.437338694500382 no 1913 0.417072646848355 2853 23741373
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.211267479578287 0.436773150717104 no 1914 0.416339278860874 2746 1241132 A phosphatase inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.211487165211739 0.436707051765653 no 1915 0.416253573201175 2879 616764
SGTC_1515 3460-0031 42.1 µM -0.211570038038631 0.436682117471803 no 1916 0.416221243171212 2798 2876596
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.217093723741857 0.435020755043748 no 1917 0.41406765253249 3002 165506
SGTC_1182 1222-0449 220 µM -0.217429044177475 0.434919937123618 no 1918 0.413936999290401 2850 658318
SGTC_1785 bathophenanthroline 24 µM -0.218124186960427 0.434710947988578 no 1919 0.41366617631286 2808 72812 An iron chelator.
SGTC_1624 st003710 6.25 µM -0.218872294459341 0.434486055814409 no 1920 0.413374764512959 2979 24207033
SGTC_3104 9120930 49.47 µM -0.219353272214626 0.434341477981482 no 1921 0.41318743348143 2876 17014836
SGTC_1970 st070122 35.8 µM -0.219750804999433 0.434221989626203 no 1922 0.413032617480671 2964 102928
SGTC_739 1486-1183 203 µM -0.221638125264038 0.433654790801652 no 1923 0.412297800432131 2886 4346692
SGTC_2052 5265182 7.135 µM -0.221736838241621 0.433625128210599 no 1924 0.41225937555009 2948 1239884
SGTC_337 1315-0038 354 µM -0.22252713691701 0.43338766222338 no 1925 0.411951775292139 2810 1626437
SGTC_816 0325-0417 81.3 µM -0.222917122611215 0.433270489637345 no 1926 0.411800004878234 2864 68101
SGTC_476 mead acid 10 µM -0.223239684491533 0.433173579207077 no 1927 0.411674483703114 2805 5312531 An omega 9 fatty acid.
SGTC_621 3584-0052 32.1 µM -0.223985686806022 0.432949465815836 no 1928 0.411384220290256 2834 2273927
SGTC_1035 k081-0041 55.2 µM -0.22586657705417 0.432384506224753 no 1929 0.410652596872896 2838 731709
SGTC_1646 st011709 75.6 µM -0.22836035522439 0.431635667895434 no 1930 0.409683053574051 2889 5757843
SGTC_1363 1636-0063 10.4 µM -0.229905629146421 0.431171772015856 no 1931 0.409082551030099 2816 6072185
SGTC_3245 9134821 49.47 µM -0.230053527863374 0.431127377343883 no 1932 0.409025087880993 2817 17014901
SGTC_246 cycloheximide 667 µM -0.230907208128996 0.43087114565784 no 1933 0.408693445386309 2804 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_815 1582-0027 36.9 µM -0.23119440367501 0.430784950600151 no 1934 0.408581888733943 2915 3128206
SGTC_516 3992-2719 87.3 µM -0.233768153125559 0.43001264726118 no 1935 0.407582487355518 2755 5350887 YDR037W KRS1
SGTC_2589 lobaric acid 100 µM -0.23388607524997 0.429977268836523 no 1936 0.407536711885864 2846 73157 A novel microtubule depolymerizer.
SGTC_678 1218-2179 85.9 µM -0.234477018916757 0.429799985253324 no 1937 0.407307336099076 2811 6820081 YOR116C RPO31
SGTC_1015 4130-4525 82 µM -0.238575252397847 0.428570903205625 no 1938 0.405717478388058 2846 1363237
SGTC_2218 6965428 192.983 µM -0.238783390860418 0.428508499749061 no 1939 0.405636774956282 2829 675684
SGTC_1060 3448-7350 82 µM -0.242055203829495 0.427527790359 no 1940 0.404368694147454 2947 570178
SGTC_3140 9094243 49.47 µM -0.242439693269259 0.42741257087036 no 1941 0.404219740395001 2797 19291112
SGTC_2134 5324836 1.464 µM -0.244661966739445 0.426746746447211 no 1942 0.403359089630199 2870 699272
SGTC_1591 genipin 88.4 µM -0.245630029656819 0.426456766305883 no 1943 0.402984320481728 2977 442424 A DNA cross-linking agent.
SGTC_1923 st058458 19.1 µM -0.245792158493636 0.426408205014941 no 1944 0.402921563752997 3086 3534982
SGTC_706 4262-0057 46.9 µM -0.245852210451448 0.426390218364627 no 1945 0.402898319513343 2843 883298
SGTC_2575 plumbagin 510 nM -0.246505343117513 0.426194603183075 no 1946 0.402645534411583 2795 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1222 0366-0074 1.18 µM -0.246533780126263 0.426186086626285 no 1947 0.402634529222003 2981 286520
SGTC_324 1315-0088 19.6 µM -0.246700006282067 0.426136304494867 no 1948 0.402570200850831 2921 6787421
SGTC_2555 cholic acid 100 µM -0.24779623062985 0.425808031976008 no 1949 0.40214603575891 3003 6708657 Influences liver metabolism.
SGTC_1314 1222-0010 41.1 µM -0.248184987210537 0.425691628269495 no 1950 0.401995640756698 2887 3526027
SGTC_1849 st056239 19.2 µM -0.249374531668526 0.425335488366865 no 1951 0.401535541872727 2845 5393181
SGTC_967 1306-0166 352 µM -0.250167632406894 0.425098074306269 no 1952 0.401228857568474 3000 4437607
SGTC_71 0417-1750 47.813 µM -0.250268575614443 0.425067858986015 no 1953 0.401189828177626 3062 6811472
SGTC_234 nsc-17383 10.7 µM -0.25046419117085 0.425009306654182 no 1954 0.401114196811839 2996 408974
SGTC_2708 st078559 56 µM -0.25287551985032 0.424287675601116 no 1955 0.400182203558615 2926 17250902
SGTC_2772 vinpocetine 57.06 µM -0.253158952243917 0.424202870263728 no 1956 0.40007269242434 3045 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_65 0798-0905 34.986 µM -0.254571257659236 0.423780349084545 no 1957 0.399527130488857 3254 3602145
SGTC_2479 5617353 43.85 µM -0.25464511228647 0.423758256309614 no 1958 0.3994986064424 3008 2731746
SGTC_652 0437-0092 114 µM -0.254859497365151 0.423694126800117 no 1959 0.399415809930999 2864 3091274
SGTC_3042 9091578 49.47 µM -0.257147761865132 0.423009759131579 no 1960 0.398532354112907 2859 25236497
SGTC_3186 9110464 49.47 µM -0.257167202652237 0.423003945828134 no 1961 0.39852485061148 2981 17018021
SGTC_3138 9097216 49.47 µM -0.257530365887307 0.422895353612393 no 1962 0.398384688501682 2799 25237486
SGTC_1347 1493-0251 600 nM -0.258442747345844 0.422622561321556 no 1963 0.398032614610645 2992 3986378
SGTC_2648 atorvastatin 78.68 µM -0.25881225840258 0.42251209201978 no 1964 0.397890049611179 2965 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3283 9109332 35.8195 µM -0.258963337089253 0.422466927177446 no 1965 0.397831764258291 2849 17027281
SGTC_565 1418-0001 44.5 µM -0.261247661921269 0.421784154809943 no 1966 0.396950762510345 3052 2862145
SGTC_2067 5224629 34.075 µM -0.262214213518875 0.421495328402554 no 1967 0.396578147936277 3013 2835000
SGTC_2096 5468907 200 µM -0.262841630071963 0.421307865435993 no 1968 0.396336323576718 3007 759785
SGTC_2066 5222451 176 µM -0.263016883925924 0.421255505311295 no 1969 0.396268782829016 2866 2281147
SGTC_1063 disulfiram 1.84 µM -0.264695371083838 0.420754098864252 no 1970 0.395622071843703 2862 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.26475662841323 0.420735802181119 no 1971 0.395598475186809 2832 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1486 3970-0793 4.53 µM -0.265074038559462 0.420640999079327 no 1972 0.395476213200603 2974 2844330
SGTC_482 fipronil 114 µM -0.265222596102179 0.420596629942954 no 1973 0.395418994428562 2876 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1010 4112-3296 15.2 µM -0.268285015824587 0.419682213810178 no 1974 0.394239969612453 3039 704384
SGTC_2208 7283366 200 µM -0.268574009620198 0.419595944684591 no 1975 0.394128757479926 2972 898663
SGTC_2278 7948257 134.34 µM -0.269311597552061 0.419375780785552 no 1976 0.393844954109499 3039 1247028
SGTC_1977 st070720 65.3 µM -0.271362343196988 0.418763783013484 no 1977 0.393056180772431 2989 682188
SGTC_3182 9108849 49.47 µM -0.271695300115697 0.41866443820286 no 1978 0.392928157684722 2983 17133045
SGTC_1462 k081-0014 26.5 µM -0.271869124423347 0.41861257606723 no 1979 0.392861326237061 2900 3270634
SGTC_875 0709-0210 25.7 µM -0.272192020183011 0.418516240801142 no 1980 0.392737188629055 2973 6251364
SGTC_2965 9082772 38.63 µM -0.272792170301049 0.41833720027147 no 1981 0.392506489289459 3067 16459634
SGTC_1012 4112-3522 18 µM -0.273449171710104 0.418141218909452 no 1982 0.392253979463449 3052 3112398
SGTC_1309 pyrazolanthrone 13.4 µM -0.274663067874013 0.41777917116971 no 1983 0.391787553888946 2985 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2795 7780010 54.55 µM -0.27492994409173 0.417699583964816 no 1984 0.391685030613425 3034 953673
SGTC_126 0417-1624 672.48 µM -0.274949630386483 0.417693713297244 no 1985 0.391677468216306 2984 41912 YDL195W SEC31
SGTC_3039 9090270 49.47 µM -0.276797795956161 0.417142652060961 no 1986 0.390967686823856 3005 17173750
SGTC_1247 0448-0043 5.84 µM -0.278319219324571 0.41668913650075 no 1987 0.390383661924707 3014 3089013 YGL099W LSG1
SGTC_1154 4088-0362 150 µM -0.280393955831568 0.416070864616504 no 1988 0.389587636847047 2876 6618304
SGTC_1676 st018489 23.4 µM -0.280746677066699 0.415965774229263 no 1989 0.389452352389637 2927 3696235
SGTC_452 diindolylmethane 8 µM -0.281023823940066 0.415883204815722 no 1990 0.389346063496243 3012 3071 Inhibits expression of several cancer promoting factors.
SGTC_952 1185-0122 232 µM -0.281973521278925 0.415600292941746 no 1991 0.388981906885641 2846 678600
SGTC_686 1319-0111 510 µM -0.282039511890789 0.415580636168078 no 1992 0.388956606740909 3064 4562600
SGTC_2264 7948757 110.76 µM -0.282399185050914 0.415473503220368 no 1993 0.388818719905974 2845 2971411
SGTC_1468 k284-1086 134 µM -0.285566494013547 0.414530354558716 no 1994 0.387605084557465 2946 15996457
SGTC_2985 9022375 71.43 µM -0.285914236791487 0.414426835007484 no 1995 0.387471904670682 3103 4939335
SGTC_519 k048-0011 62.8 µM -0.286266090623755 0.414322097685986 no 1996 0.387337163792745 3025 6836379
SGTC_1443 4112-3303 14 µM -0.286757301536355 0.414175887740897 no 1997 0.387149079434856 2922 704433
SGTC_1791 st048313 56.1 µM -0.291012981950982 0.412909675625733 no 1998 0.385520695419772 3048 1204976
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.293078186052535 0.412295531503274 no 1999 0.38473119502659 2992 77254
SGTC_1027 k015-0025 8.67 µM -0.293735032875585 0.412100245320448 no 2000 0.384480191101609 2902 3598955
SGTC_1445 4239-0156 97.7 µM -0.294225891081365 0.411954323180856 no 2001 0.384292648786393 3106 4008346
SGTC_780 0109-0199 192 µM -0.302159145656691 0.409597630255636 no 2002 0.381265373247069 3119 610414
SGTC_521 r062-0005 13.8 µM -0.30273626551211 0.409426314390306 no 2003 0.381045428995229 2914 2832033
SGTC_2906 7926292 26.41 µM -0.30310641149736 0.409316447043451 no 2004 0.380904384095779 3061 2966319
SGTC_2523 spermine 47.74 µM -0.304139329655248 0.409009892254407 no 2005 0.380510872222449 3057 1103 A DNA binding polyamine.
SGTC_2071 5230951 39.92 µM -0.308774755540079 0.407634854378497 no 2006 0.378746436782026 3020 1799272
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.310059813161138 0.40725385959855 no 2007 0.378257735848614 3010 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3306 9127676 59.7925 µM -0.31058940123188 0.407096872464602 no 2008 0.378056392781508 3031 41905287
SGTC_1611 st001856 99.4 µM -0.310979666985269 0.406981194547872 no 2009 0.377908039587941 2980 647478
SGTC_1250 0485-0349 40.2 µM -0.314775820813183 0.405856408736324 no 2010 0.376465935690171 2973 6842794 YDL195W SEC31
SGTC_249 wiskostatin 11.211 µM -0.315435588918848 0.405661000948286 no 2011 0.37621547447821 3040 2775510 A n-wasp and actin depolymerizer.
SGTC_1416 3966-0321 25.3 µM -0.315651933825288 0.405596929793251 no 2012 0.376133356952985 3015 582530 YLR208W SEC13
SGTC_153 4077-0274 519.67 µM -0.316997572585728 0.405198471927245 no 2013 0.375622722070936 3272 3121976
SGTC_1693 xanthone 101.9 µM -0.318140380567048 0.404860151530626 no 2014 0.375189227165164 2984 7020 An insecticide.
SGTC_2162 5663267 200 µM -0.318204994001752 0.404841025291664 no 2015 0.375164722417183 3127 6456493
SGTC_2703 st077852 53.4 µM -0.319065217063754 0.404586412125289 no 2016 0.374838529491177 3095 6281836
SGTC_688 0527-0193 473 µM -0.319434331899687 0.404477172031961 no 2017 0.374698590149279 2982 4007154
SGTC_1077 5-fluorocytosine 377 nM -0.319671422695266 0.404407008579769 no 2018 0.37460871265077 3035 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1169 aniline yellow 25.8 µM -0.319746920357087 0.404384666828404 no 2019 0.374580094070236 3000 6051 A DNA damaging agent.
SGTC_827 3253-0474 693 µM -0.321207799840161 0.403952415493807 no 2020 0.374026460835223 3101 5402065
SGTC_2961 9083290 32.55 µM -0.32249166598182 0.403572636416264 no 2021 0.373540125192842 3046 17741490
SGTC_891 0929-0073 133 µM -0.325128306955543 0.402792979867711 no 2022 0.372541982962625 3103 5603632
SGTC_1392 3455-1037 33.9 µM -0.326319832841411 0.4024407714175 no 2023 0.372091192172987 3136 981132
SGTC_1357 1503-1303 39.5 µM -0.32682501441363 0.402291466428975 no 2024 0.371900119355848 3006 292895
SGTC_1922 5578187 25 µM -0.327966093623617 0.401954276178126 no 2025 0.371468649666605 3181 1350412
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.328035189221079 0.401933860688043 no 2026 0.371442528126316 3390 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1873 rapamycin 2 nM -0.329411138161119 0.401527368549789 no 2027 0.370922475064909 2998 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1476 4112-3294 3.34 µM -0.330561669068489 0.401187552694574 no 2028 0.370487801780848 3123 704369
SGTC_1463 k081-0032 34.1 µM -0.330703415562868 0.40114569222591 no 2029 0.370434261047332 3049 977755
SGTC_611 3453-1652 23.7 µM -0.332026129955364 0.400755123963491 no 2030 0.369934764164392 3093 1560575
SGTC_1714 st033236 13.627 µM -0.332138041223797 0.400722083590425 no 2031 0.369892513143285 3187 2916566
SGTC_1968 st069590 43.6 µM -0.336616645579573 0.399400418201121 no 2032 0.368202953226481 3121 6384066
SGTC_1436 4092-1007 8.32 µM -0.337662211958287 0.399092030061517 no 2033 0.367808877166626 3018 2881121
SGTC_311 1315-0136 58 µM -0.339330215336634 0.398600185549328 no 2034 0.367180491479688 3181 6759207
SGTC_2889 9059656 51.95 µM -0.339426769705655 0.398571719464367 no 2035 0.367144127495294 3086 3949838
SGTC_2732 terfenadine 20 µM -0.34003325398266 0.39839292858131 no 2036 0.366915742674509 2992 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1093 fluphenazine 7.97 µM -0.340392380501467 0.398287068538121 no 2037 0.366780527982283 3009 6602611 An atypical antipsychotic.
SGTC_2390 9097792 176.6 µM -0.342861560412767 0.397559429232197 no 2038 0.365851305585678 3004 4497149
SGTC_2017 5132927 60.65 µM -0.344663841056825 0.397028542360792 no 2039 0.365173552448893 3007 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2302 7771753 200 µM -0.347949818361473 0.396061103550699 no 2040 0.363938935235201 3092 2203047
SGTC_2276 7947513 42.08 µM -0.348386590721625 0.39593255955388 no 2041 0.363774935788364 3090 2105100
SGTC_369 0957-0393 4.5 µM -0.350962650363472 0.395174644680384 no 2042 0.362808184470359 3063 6997992
SGTC_3323 9138564 53.9225 µM -0.351788260644301 0.394931821659321 no 2043 0.362498531588633 3190 43912313 YNL103W MET4
SGTC_2032 5185112 25.99 µM -0.354684616101512 0.39408028804636 no 2044 0.361412938592491 3071 5718189
SGTC_3014 9081533 49.47 µM -0.355038837899687 0.39397618086359 no 2045 0.361280247832907 3161 21367265
SGTC_413 propylparaben 100 µM -0.355859559182729 0.393734996766863 no 2046 0.360972871467404 3018 7175 A pharmaceutical preservative.
SGTC_1464 k208-0027 110 µM -0.356276809876138 0.393612395571903 no 2047 0.360816637229074 3222 X1464
SGTC_2383 9036125 200 µM -0.358715557092085 0.392896027329548 no 2048 0.359903944529846 3031 79580
SGTC_39 0986-0283 58.349 µM -0.358967813424028 0.392821949106722 no 2049 0.359809583936019 3224 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_182 3448-4371 550.524 µM -0.360445830338301 0.392387989064145 no 2050 0.359256879472768 3078 3491403
SGTC_2087 5276107 200 µM -0.36131726718028 0.392132189445583 no 2051 0.358931143522385 3012 144405
SGTC_1049 3226-0134 66 µM -0.363026575457706 0.391630578392203 no 2052 0.358292516137365 3101 5702385
SGTC_3168 9103419 49.47 µM -0.363277270219127 0.391557025008379 no 2053 0.358198885475475 3118 16649256
SGTC_1255 0566-0045 221 µM -0.363396458983378 0.391522056602835 no 2054 0.358154373283962 3189 2788469
SGTC_729 4092-0585 94.1 µM -0.366514160706716 0.390607676338182 no 2055 0.356990723966933 3028 2169061
SGTC_1833 st055984 71 µM -0.367262359961958 0.390388329263083 no 2056 0.356711663837763 3077 676288
SGTC_399 oxolinic acid 75 µM -0.369433526771665 0.38975201327283 no 2057 0.355902305955215 3055 4628 A DNA gyrase inhibitor.
SGTC_2374 9071832 200 µM -0.370330143583506 0.389489322854619 no 2058 0.35556825827628 3093 17381698
SGTC_705 1124-0212 310 µM -0.370928721487849 0.389313979845859 no 2059 0.355345311059297 3219 9554485
SGTC_920 mycophenolic acid 780.421 nM -0.372467113606338 0.388863438034637 no 2060 0.354772546476556 3076 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_582 0987-0078 156 µM -0.372866470270971 0.388746504693843 no 2061 0.354623914082117 3203 1625765
SGTC_526 4469-0568 170 µM -0.373802193977983 0.388472560280092 no 2062 0.354275743540549 3058 2901964
SGTC_2840 9008771 71.43 µM -0.375814144454058 0.387883725486801 no 2063 0.35352753580809 3148 2992978
SGTC_669 0108-0021 26.2 µM -0.377519909913283 0.387384703245748 no 2064 0.352893635577699 3378 17201
SGTC_1920 st075728 45.7 µM -0.378544299461495 0.387085107094669 no 2065 0.352513145749331 3232 3400306
SGTC_2921 7974240 10.71 µM -0.379566481665727 0.386786223545547 no 2066 0.352133622836318 3192 2979074 YDR527W RBA50
SGTC_2737 bleomycin 30.5 nM -0.381724473569646 0.386155452713045 no 2067 0.351332872502631 3118 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2829 7992743 58.44 µM -0.382403124852368 0.385957148243636 no 2068 0.351081186447486 3214 16462845
SGTC_736 0958-0254 92.6 µM -0.383217322963429 0.385719275798601 no 2069 0.350779317394026 3184 6812352
SGTC_737 1950-0117 57.9 µM -0.383955112371133 0.385503763683202 no 2070 0.350505858672765 3209 5393513
SGTC_2419 paclitaxel 166.5 µM -0.384144685870998 0.385448393985224 no 2071 0.350435606508596 3056 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2127 5253358 187.912 µM -0.385074302281626 0.385176909998345 no 2072 0.350091183270639 3008 20612
SGTC_3050 9093513 49.47 µM -0.386446739462654 0.384776208089137 no 2073 0.349582920177775 3096 25236664
SGTC_401 neomycin 50 µM -0.386465736682589 0.384770662451935 no 2074 0.349575886709737 3122 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.386695423229119 0.384703614598971 no 2075 0.349490852407504 3058 91467 include heat shock
SGTC_1341 1486-1360 280 µM -0.388053705924369 0.384307188534904 no 2076 0.348988144987165 3079 3976547
SGTC_635 k038-0028 24.7 µM -0.388317551299457 0.384230197095051 no 2077 0.348890525156645 3114 4035102
SGTC_530 4358-1714 28 µM -0.388365895423692 0.384216090525567 no 2078 0.348872639456687 3145 1564641
SGTC_3267 9137951 49.47 µM -0.388701906100441 0.384118048558002 no 2079 0.348748336087644 3030 16643986
SGTC_423 5-fluorouracil 457 µM -0.389873105887777 0.383776371194718 no 2080 0.348315190891063 2997 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1815 st051655 58.2 µM -0.390426907085816 0.383614840675364 no 2081 0.348110447239548 3188 5984156
SGTC_1648 st011736 69.8 µM -0.390733019959855 0.383525563573253 no 2082 0.347997294451407 3229 2855514
SGTC_2444 5485484 36.41 µM -0.390835285177481 0.383495739539981 no 2083 0.347959495742318 3202 6790631
SGTC_563 tetrahydrosecaminediol 614 µM -0.391837320009958 0.383203548473679 no 2084 0.347589209096363 3226 334274 A psychoactive constituent of the cannabis plant.
SGTC_3337 9144342 33.5465 µM -0.39232360548232 0.383061772673556 no 2085 0.34740956210666 3191 17682949
SGTC_551 k048-0028 34.9 µM -0.392538882575211 0.382999013960707 no 2086 0.347330043874796 3234 6836383
SGTC_1605 st000082 49.1 µM -0.39339622220507 0.38274910827819 no 2087 0.347013429726951 3208 1114022
SGTC_170 4197-0004 226 µM -0.396522650849229 0.381838200733485 no 2088 0.345859750700216 3211 218692
SGTC_3099 9120367 49.47 µM -0.396564328746966 0.381826061982509 no 2089 0.345844380830899 3076 24824940
SGTC_842 0271-0008 11.1 µM -0.397583644000561 0.381529221066193 no 2090 0.345468559474006 3232 1221709
SGTC_2977 9011197 71.43 µM -0.397787159508413 0.381469962430839 no 2091 0.345393541567865 3279 2704722
SGTC_573 3702-0553 84.7 µM -0.397815185217889 0.381461802261487 no 2092 0.345383211479215 3110 1222756
SGTC_2996 9066192 71.4286 µM -0.399197684035011 0.381059329330778 no 2093 0.344873774787936 3136 6472854
SGTC_873 0591-4978 488 µM -0.399285869586373 0.381033661120778 no 2094 0.344841288840762 3284 3305145
SGTC_2442 5158906 48.48 µM -0.400726757774197 0.380614335344954 no 2095 0.344310654124345 3232 1893835
SGTC_617 3770-0098 35 µM -0.403453372190965 0.379821222939637 no 2096 0.34330736503097 3138 5962639
SGTC_1825 st052143 62.6 µM -0.404265669759689 0.379585040901284 no 2097 0.34300868378898 3270 674173
SGTC_2837 9008476 45.46 µM -0.406380166224221 0.378970444946362 no 2098 0.342231645239723 3275 2992805
SGTC_1615 st002656 86.5 µM -0.40665758368465 0.378889833921578 no 2099 0.342129748890215 3200 1584458
SGTC_2691 st077356 60.2 µM -0.407117936325314 0.378756077837413 no 2100 0.34196068521156 3273 2839272
SGTC_1571 st070080 73.4 µM -0.407300739954232 0.378702968022025 no 2101 0.341893559694632 3277 4315245
SGTC_282 k297-0036 65.7 µM -0.409600721281243 0.378034952009121 no 2102 0.341049433868418 3247 5061378
SGTC_1508 1080-0625 72.9 µM -0.411810840054045 0.377393379398622 no 2103 0.340239037708128 3138 767111
SGTC_281 1672-3440 14.9 µM -0.412197211123126 0.377281254906724 no 2104 0.340097440561569 3228 6833000
SGTC_1356 1502-0781 85.8 µM -0.412310423478655 0.377248402755315 no 2105 0.340055954804341 3121 567702
SGTC_3134 9127454 49.47 µM -0.413134461329708 0.37700930884762 no 2106 0.339754051132014 3259 24262820
SGTC_3027 9089541 49.47 µM -0.417672819070121 0.375693355287649 no 2107 0.338093173959519 3235 9943819
SGTC_1709 st033179 39.1045 µM -0.420796434469911 0.374788462288349 no 2108 0.33695186774521 3140 573381
SGTC_2531 methyl deoxycholate 70.07 µM -0.421237679138673 0.374660691726071 no 2109 0.336790766454 3106 16667744 Haematoxylin.
SGTC_1265 0819-1001 68.8 µM -0.421552913232144 0.374569418284102 no 2110 0.336675690775912 3223 3106768
SGTC_383 2324-0395 7.37 µM -0.422424645777928 0.374317051888141 no 2111 0.336357545907824 3261 3146421
SGTC_2802 7925815 54.55 µM -0.422539794766498 0.374283720302666 no 2112 0.336315530235647 3119 1262923
SGTC_616 4092-0450 108 µM -0.422775262780054 0.374215563513485 no 2113 0.336229618808187 3193 787165
SGTC_211 3455-0679 143.504 µM -0.423064080305585 0.374131969946689 no 2114 0.336124254280626 3243 748649
SGTC_1036 k216-0215 33.5 µM -0.424286252771642 0.37377829742293 no 2115 0.335678531871857 3118 622330
SGTC_1906 st060206 94.7 µM -0.424486875701666 0.373720251262255 no 2116 0.335605387391826 3267 5133468
SGTC_169 k015-0017 16.025 µM -0.424586799384061 0.373691341447408 no 2117 0.33556895885589 3365 1840002
SGTC_106 0092-0003 11.579 µM -0.424812046302683 0.373626175852347 no 2118 0.33548684770059 3189 1072148
SGTC_1692 fluoroquinolonic acid 71 µM -0.426287432666467 0.373199425111202 no 2119 0.334949207116201 3265 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_631 k072-0230 41.5 µM -0.427241016471379 0.372923686773719 no 2120 0.334601894634906 3245 5773147
SGTC_2992 9074591 71.4286 µM -0.428218254120035 0.372641176220357 no 2121 0.334246113774897 3283 17741321
SGTC_953 1188-0045 9.7 µM -0.429574845058655 0.372249111640627 no 2122 0.333752469360984 3257 6144426
SGTC_1539 benzyladenosine 56 µM -0.429671830065268 0.372221087338938 no 2123 0.333717188883826 3148 92208 A nucleotide analog.
SGTC_878 0828-0289 13.7 µM -0.43031211129187 0.372036091870547 no 2124 0.333484309092855 3168 745350 YLR208W SEC13
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.431478614258674 0.371699131911179 no 2125 0.333060199604737 3124 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_213 1246-0773 967 nM -0.433592985066119 0.371088618316985 no 2126 0.332292014855571 3205 6251622
SGTC_3117 9124945 49.47 µM -0.436394307177878 0.370280250754181 no 2127 0.331275334309109 3115 17592065
SGTC_1207 2099-0101 141 µM -0.437059122432694 0.370088491313193 no 2128 0.331034235817246 3258 5837381
SGTC_1190 1486-1332 13 µM -0.437745568707343 0.369890526498731 no 2129 0.330785366231481 3229 4150046
SGTC_3183 9108214 49.47 µM -0.437911547258113 0.369842664979322 no 2130 0.330725202295029 3232 4974831
SGTC_624 k048-0052 28 µM -0.437933116689432 0.369836445373326 no 2131 0.330717384124512 3203 6835531
SGTC_1478 0453-0656 35.7 µM -0.440300824258126 0.369153917597395 no 2132 0.329859621914301 3262 5258496
SGTC_590 k048-0076 22.4 µM -0.441282033788648 0.368871189714097 no 2133 0.329504415553723 3275 6832814
SGTC_3065 9113888 49.47 µM -0.441795272613296 0.368723332194499 no 2134 0.329318679880962 3360 16648368
SGTC_3301 9125354 19.7965 µM -0.442290850908229 0.368580580885387 no 2135 0.329139375327224 3213 41905162
SGTC_3070 9117005 49.47 µM -0.44252370312029 0.368513514075347 no 2136 0.32905514093177 3276 8779016
SGTC_602 3130-1533 38.1 µM -0.444218781825211 0.368025413119086 no 2137 0.328442207219436 3283 720941
SGTC_539 4859-0462 2.54 µM -0.444462884508025 0.367955140839857 no 2138 0.328353978630794 3300 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_491 tetrandrine 80.3 µM -0.445588796595577 0.367631070503427 no 2139 0.327947152394791 3246 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2667 digitoxin 100 µM -0.44620462357348 0.367453857387032 no 2140 0.327724721701967 3254 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3167 9103034 49.47 µM -0.446545081318075 0.367355897861015 no 2141 0.327601777915752 3274 5127859
SGTC_3032 9089427 49.47 µM -0.448175344328064 0.366886943839187 no 2142 0.327013327637126 3263 17173707
SGTC_1327 1436-0082 2.18 µM -0.44995247200735 0.366375969621915 no 2143 0.326372355593976 3206 15992205
SGTC_2146 5545642 200 µM -0.45181251799464 0.365841407686825 no 2144 0.3257020254585 3283 825326
SGTC_1263 0774-1208 64.8 µM -0.451935457023367 0.36580608518209 no 2145 0.32565774006313 3364 906585
SGTC_1908 st060353 56.5 µM -0.452691819553749 0.365588794213104 no 2146 0.325385335470795 3378 4227716
SGTC_1616 st002734 56.1 µM -0.453328084034757 0.365406038904491 no 2147 0.325156256505045 3174 4026101
SGTC_270 tamoxifen 5.46 µM -0.453438671688277 0.365374277743988 no 2148 0.325116447558534 3389 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3113 9123498 49.47 µM -0.455167483890112 0.364877876995259 no 2149 0.324494375716415 3284 8897275
SGTC_33 0986-0033 35.816 µM -0.455879685236927 0.364673445578134 no 2150 0.324238249272546 3264 2848082
SGTC_1957 st077035 62.4 µM -0.456869434954428 0.364389410128765 no 2151 0.323882447176785 3316 705593
SGTC_2038 4100038 30.985 µM -0.45726662793239 0.364275445786337 no 2152 0.32373970670167 3297 3596803
SGTC_3054 9094397 49.47 µM -0.45762132486356 0.364173684736546 no 2153 0.323612260073201 3227 2598354
SGTC_1039 k821-0043 94 µM -0.458014416263467 0.364060919662189 no 2154 0.323471042042234 3316 15992768
SGTC_1776 st049249 45.9 µM -0.458364384671982 0.363960535067631 no 2155 0.32334533733181 3261 1822314
SGTC_2930 9013230 14.89 µM -0.459138924375561 0.363738400060476 no 2156 0.323067203104605 3305 2995857
SGTC_1880 MG-132 525 µM -0.460497291132469 0.363348936317548 no 2157 0.32257965771008 3321 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2179 6298986 200 µM -0.4631304617542 0.362594370053125 no 2158 0.32163542828663 3319 738374
SGTC_1002 4049-0206 172 µM -0.463763938650354 0.36241291921951 no 2159 0.321408441154569 3223 4662749
SGTC_342 k048-0088 23.3 µM -0.464109619953565 0.362313916546395 no 2160 0.321284604913421 3192 6820570
SGTC_2005 4024620 188 µM -0.466306871334775 0.361684842161618 no 2161 0.320497930513813 3263 236743
SGTC_2215 7188065 200 µM -0.468101653119601 0.361171272204141 no 2162 0.319855948571701 3337 940217
SGTC_2766 oltipraz 83.91 µM -0.469018022705066 0.360909152940689 no 2163 0.319528376846443 3326 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2091 4-phenylthiadiazole 200 µM -0.470402168552781 0.360513354358417 no 2164 0.319033857571213 3193 270010
SGTC_123 0083-0120 66.675 µM -0.470546409404945 0.360472117059034 no 2165 0.318982342576505 3242 16001701
SGTC_2880 9042983 58.44 µM -0.47147470060469 0.360206764919871 no 2166 0.318650891093231 3334 6464714
SGTC_508 roscovitine 141 µM -0.471935456485034 0.360075082798149 no 2167 0.3184864295146 3297 160355 A CDKinase inhibitor.
SGTC_825 1988-2224 89.6 µM -0.4719919427815 0.360058940390759 no 2168 0.318466269832623 3225 1180859
SGTC_2265 7929201 200 µM -0.47215661973126 0.360011881154745 no 2169 0.318407500505167 3147 1265108
SGTC_1239 0337-0584 35.4 µM -0.473346327002138 0.359671965160236 no 2170 0.317983057807759 3398 914301 YML130C ERO1
SGTC_1893 st059353 36.1 µM -0.473847946456225 0.359528678717483 no 2171 0.31780417048831 3277 3112488
SGTC_1292 0kpi-0043 232 µM -0.475800413964367 0.358971149051652 no 2172 0.317108287460213 3285 3333905
SGTC_1899 st063254 59.6 µM -0.477454720461806 0.358498994586527 no 2173 0.31651917822515 3193 3093813
SGTC_3035 9091303 49.47 µM -0.478269684469206 0.358266475725948 no 2174 0.316229135206331 3312 25237002
SGTC_1444 4112-3581 28 µM -0.478462271645339 0.358211536002357 no 2175 0.316160610567239 3290 2877249
SGTC_2474 5321570 43.32 µM -0.480823290345152 0.357538242448613 no 2176 0.315321047879339 3310 2841384
SGTC_2113 5491891 107.031 µM -0.48187953554772 0.357237175517007 no 2177 0.314945762226679 3279 789979
SGTC_2240 6690706 185.951 µM -0.482095810095924 0.357175540638161 no 2178 0.314868943068538 3136 805876
SGTC_306 1672-3436 11.6 µM -0.484730796516486 0.3564249102564 no 2179 0.313933658960805 3348 6797378
SGTC_999 SEC7.066 22.7 µM -0.485315996870025 0.356258279164628 no 2180 0.313726104891333 3233 740511 YDR170C SEC7
SGTC_139 0099-0334 718.624 µM -0.489709491117962 0.355008145441593 no 2181 0.312169742368231 3314 97690
SGTC_3173 9105693 49.47 µM -0.491381317201348 0.354532849491264 no 2182 0.311578387818358 3430 17096658
SGTC_1612 st002233 45.4 µM -0.491690014905257 0.354445112252383 no 2183 0.311469249036346 3371 1035021
SGTC_3136 9095672 49.47 µM -0.492849135300062 0.354115739121837 no 2184 0.311059594801926 3280 17217380
SGTC_2262 9014885 67.46 µM -0.493263753948866 0.353997948472107 no 2185 0.310913117817708 3284 6457424
SGTC_3212 9128307 49.47 µM -0.495097120425908 0.353477267760165 no 2186 0.310265783183693 3139 27243542
SGTC_1321 1326-2144 215 µM -0.495708292812421 0.353303754120395 no 2187 0.310050117684631 3342 3513030
SGTC_2403 6032726 181.2 µM -0.496299092722138 0.353136053266128 no 2188 0.309841703156107 3298 2881040
SGTC_2186 6124449 200 µM -0.49647833102648 0.353085181412656 no 2189 0.309778485930648 3361 3834182 YLR033W RSC58
SGTC_1807 st050092 58.9 µM -0.499096328848331 0.352342434550459 no 2190 0.30885576184883 3284 5008496
SGTC_3234 9132280 49.47 µM -0.500045961264387 0.352073155200416 no 2191 0.308521357544355 3355 17612295
SGTC_1526 st051518 75 µM -0.500488355929138 0.351947734345719 no 2192 0.30836562653249 3270 673993
SGTC_2588 indole-3-carbinol 100 µM -0.502280416617262 0.351439842068277 no 2193 0.307735141337138 3394 3712 Induces cell cycle arrest.
SGTC_1765 st044815 90.4 µM -0.503665166123849 0.351047568373081 no 2194 0.307248345342433 3326 645695
SGTC_1942 st076330 65.2 µM -0.506501676262648 0.350244533771365 no 2195 0.306252256615323 3427 24208414
SGTC_2476 5806916 10.51 µM -0.508403571428084 0.349706469242302 no 2196 0.305585174335953 3264 2870194
SGTC_2059 5238311 157 µM -0.508660856488183 0.349633703958862 no 2197 0.305494982076149 3253 703021
SGTC_1460 k062-0059 9.15 µM -0.510096711033684 0.349227717510201 no 2198 0.304991854643342 3283 1373085
SGTC_92 0063-0024 660.874 µM -0.51209830578726 0.348662056440704 no 2199 0.30429110510551 3368 3594437
SGTC_2251 lansoprazole 556 µM -0.513289819683749 0.348325488016905 no 2200 0.303874302066502 3212 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1734 st037168 69.4 µM -0.515945949203096 0.347575637857662 no 2201 0.302946080239988 3341 708907
SGTC_154 3389-1638 511.116 µM -0.516044889334836 0.347547717630968 no 2202 0.3029115287468 3330 5238686
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.517333184139435 0.347184245211862 no 2203 0.302461796498549 3387 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2277 7947813 106.88 µM -0.51782832710963 0.34704458565799 no 2204 0.302289026177305 3474 1246798
SGTC_1675 st018485 24.5 µM -0.518610060466111 0.346824132987195 no 2205 0.302016346002434 3322 3323024
SGTC_1055 3448-0672 86 µM -0.519395460471325 0.346602698513887 no 2206 0.301742498151359 3403 748378
SGTC_1830 st055982 50.3 µM -0.520908797154842 0.346176178503615 no 2207 0.301215153408983 3395 455313 An antimicrobial agent.
SGTC_1108 betulinic acid 729.144 nM -0.521814666157712 0.345920960945354 no 2208 0.300899688604375 3344 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_807 1315-0151 48 µM -0.523071454729159 0.345566991994098 no 2209 0.300462264577978 3491 4011080
SGTC_480 am 92016 50 µM -0.524787456147716 0.345083905796844 no 2210 0.299865476276059 3360 2129 K+ channel blocker.
SGTC_1459 k035-0031 35.7 µM -0.524887512457857 0.345055745870343 no 2211 0.299830695410235 3300 3877128 YMR208W ERG12
SGTC_1665 st014639 11.4 µM -0.52528387527246 0.344944201641889 no 2212 0.299692932528442 3429 981133 YIL048W NEO1
SGTC_3023 9089636 49.47 µM -0.52547299346554 0.344890984840453 no 2213 0.299627211273 3474 17249241
SGTC_2255 7941087 197.44 µM -0.525587096718411 0.344858878307511 no 2214 0.29958756193239 3442 935561
SGTC_2175 5807670 165.306 µM -0.525936449247408 0.344760583951236 no 2215 0.299466181429164 3387 241186
SGTC_93 0109-0045 59.227 µM -0.526973901072843 0.3444687467181 no 2216 0.299105856312277 3443 88733
SGTC_1493 4348-0038 111 µM -0.527725838729493 0.344257283025642 no 2217 0.298844818329591 3425 800424
SGTC_188 3229-0966 278.469 µM -0.528841597456833 0.343943593468763 no 2218 0.298457669376213 3446 5722370
SGTC_2792 7535235 81.82 µM -0.529419523501887 0.34378115487484 no 2219 0.298257228806477 3329 1281891
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.529706767791222 0.343700429390718 no 2220 0.298157627434659 3436 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2864 9034755 47.6 µM -0.531381086320877 0.343230030472893 no 2221 0.297577362683384 3439 4930451
SGTC_783 0848-0141 92.7 µM -0.533196843198978 0.342720168947354 no 2222 0.296948663265275 3392 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1674 st016616 23.6 µM -0.533248607544542 0.342705637798868 no 2223 0.296930748955326 3304 625830
SGTC_642 0335-0876 158 µM -0.533280673072229 0.34269663656653 no 2224 0.296919652148121 3378 6812350
SGTC_2984 9022109 38.96 µM -0.535282702983813 0.342134816426126 no 2225 0.2962271926243 3471 6459207
SGTC_810 3825-7150 143 µM -0.536960104455707 0.34166436407144 no 2226 0.295647586118207 3466 22330411 YGL099W LSG1
SGTC_1271 0832-2808 169 µM -0.539650158516584 0.340910411616956 no 2227 0.294719159249614 3451 3663794
SGTC_1285 0929-0069 65.5 µM -0.540548062143816 0.340658893682238 no 2228 0.294409562494205 3368 1206237
SGTC_3258 9138477 49.47 µM -0.542174567726246 0.340203462491614 no 2229 0.293849126786714 3437 4970355
SGTC_2416 tofa 880 nM -0.543048592867275 0.339958826484968 no 2230 0.293548172939486 3297 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2358 9037157 4 µM -0.543475268044291 0.339839426341787 no 2231 0.293401307364419 3405 2388925
SGTC_2711 st079103 59.1 µM -0.543790931226322 0.339751101968346 no 2232 0.293292675067587 3363 54693780
SGTC_2064 5220758 200 µM -0.546021008248936 0.339127364466275 no 2233 0.292525748186081 3493 788518
SGTC_2006 4011487 200 µM -0.54655276080811 0.338978701860862 no 2234 0.29234301537353 3483 45595294
SGTC_3108 9121785 49.47 µM -0.548653662771492 0.338391595954092 no 2235 0.291621575718051 3418 17140271
SGTC_3126 9127922 49.47 µM -0.548976700217484 0.338301356571884 no 2236 0.291510719873404 3493 45595682
SGTC_2140 5586273 200 µM -0.549048936426861 0.338281178909451 no 2237 0.291485933467238 3433 854421
SGTC_1856 st057054 55.7 µM -0.549107235240368 0.338264894703424 no 2238 0.291465930115705 3528 1266018
SGTC_723 4182-0001 115 µM -0.549631161627966 0.338118563533421 no 2239 0.291286190469567 3364 744821 YLR208W SEC13
SGTC_1293 1000-1278 195 µM -0.550618645356346 0.337842828590431 no 2240 0.290947562268738 3489 678847
SGTC_3199 9111318 49.47 µM -0.552965172168918 0.337187957449224 no 2241 0.290143629444513 3396 8548020
SGTC_1219 1469-0211 33.1 µM -0.553184809216302 0.337126686117197 no 2242 0.290068433906665 3435 6822282
SGTC_1509 1326-1131 80 µM -0.553849831438259 0.336941193685935 no 2243 0.289840810804915 3425 768313
SGTC_329 k048-0121 21.3 µM -0.554990469696977 0.336623131599591 no 2244 0.28945058957349 3444 6832902
SGTC_492 tmb-8 126 µM -0.557078682327863 0.336041145343566 no 2245 0.288736835909103 3374 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2089 5281248 129.67 µM -0.557530579761421 0.335915252884095 no 2246 0.288582485952126 3460 2737878
SGTC_796 1234-0020 70.7 µM -0.558094184526098 0.335758266082756 no 2247 0.288390035762542 3434 46495034
SGTC_2979 9012552 45.46 µM -0.559093118400411 0.335480092877408 no 2248 0.288049085506804 3504 17100905
SGTC_451 chloral hydrate 100 µM -0.55924927507765 0.335436616058315 no 2249 0.287995804224299 3461 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2012 4023501 200 µM -0.559530541938161 0.335358311880197 no 2250 0.287899846585664 3373 3477460
SGTC_2908 7930301 100 µM -0.561756679306957 0.334738811872802 no 2251 0.287140905664129 3371 2223178
SGTC_2449 5812982 45.77 µM -0.56210393526216 0.334642216336813 no 2252 0.28702260365439 3439 776185
SGTC_2733 amorolfine 100 µM -0.562668059420168 0.334485318311115 no 2253 0.286830468929458 3447 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1919 st067113 52.3 µM -0.564641796613463 0.333936596797969 no 2254 0.286158715069137 3454 1268243
SGTC_361 000s-0510 1.45 µM -0.56496161316221 0.333847717518464 no 2255 0.286049937132325 3412 660
SGTC_1163 k060-0048 49.9 µM -0.565038784123482 0.33382627255854 no 2256 0.286023692221646 3460 6809982
SGTC_2201 6605497 169.863 µM -0.566076823053382 0.333537865751562 no 2257 0.285670779002215 3429 670741
SGTC_402 epigallocatechin gallate 10 µM -0.566442363862009 0.333436327979588 no 2258 0.28554655151938 3386 65064 An antioxidant.
SGTC_2325 6158266 200 µM -0.56685054748386 0.333322959559115 no 2259 0.285407862454249 3426 3623240
SGTC_2242 6630449 61.2675 µM -0.568134850324117 0.332966358208485 no 2260 0.28497170262724 3454 691249 YDR170C SEC7
SGTC_1567 st069303 68.4 µM -0.569188714505392 0.332673853558455 no 2261 0.284614039275892 3482 5581319
SGTC_2248 tofa 1.1 µM -0.56964761757874 0.332546514801923 no 2262 0.284458362492659 3397 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1181 1222-0449 220 µM -0.571892359610238 0.331923911009894 no 2263 0.283697450259059 3540 658318
SGTC_2731 amoxapine 43.43 µM -0.574097706140066 0.331312685615222 no 2264 0.282950842761463 3492 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_178 4092-0806 87.505 µM -0.574416875212759 0.33122426310102 no 2265 0.282842868085606 3481 2169044
SGTC_766 1391-0721 126 µM -0.575511621691132 0.330921046344944 no 2266 0.282472666538695 3499 1020919 YIL115C NUP159
SGTC_3197 9113331 49.47 µM -0.577130025426166 0.330472993090588 no 2267 0.281925811288909 3549 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_136 0097-0015 404.482 µM -0.577996636495772 0.330233172597189 no 2268 0.281633195037586 3512 4861337
SGTC_3328 9140624 29.0385 µM -0.578309049729521 0.330146734418454 no 2269 0.281527742825139 3496 4904392
SGTC_2349 9023730 187.07 µM -0.578971055788961 0.329963601210069 no 2270 0.281304351733748 3504 4126287
SGTC_2402 5553605 200 µM -0.579440678705335 0.329833712368947 no 2271 0.28114593140496 3536 6758546
SGTC_1822 st052468 42 µM -0.579941851764495 0.329695119983655 no 2272 0.280976915647961 3408 2873678
SGTC_219 mitoxanthrone 164.414 µM -0.58089800639636 0.329430773691988 no 2273 0.280654598032346 3442 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1879 gemcitabine 100 µM -0.580939716573362 0.329419244095984 no 2274 0.280640541696321 3468 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2389 9091542 195.52 µM -0.582569984483093 0.328968729889243 no 2275 0.280091408140737 3423 3626624 YOL127W RPL25
SGTC_2832 7992762 51.95 µM -0.583998492965657 0.328574174724965 no 2276 0.279610662979749 3288 2985177
SGTC_1820 st053765 18.6 µM -0.587419857852097 0.327629968461098 no 2277 0.27846088014136 3482 3690829
SGTC_2462 5162487 171.77 µM -0.588428943918098 0.327351697402081 no 2278 0.278122207424692 3483 2259986
SGTC_2472 5377652 49.4 µM -0.589398150696001 0.327084513966913 no 2279 0.277797108395753 3468 1610903
SGTC_720 r052-1644 49.9 µM -0.590982682098339 0.326647893463109 no 2280 0.277266012270233 3493 1422863 YOR257W CDC31
SGTC_1752 st044819 83.042 µM -0.592639746953181 0.326191540089657 no 2281 0.276711136477282 3421 441209 YML126C ERG13
SGTC_1223 0764-0573 147 µM -0.593126925371514 0.326057421277432 no 2282 0.276548106098996 3519 1609797
SGTC_3085 9117376 49.47 µM -0.593752126954847 0.32588533804984 no 2283 0.27633895638055 3516 16480349
SGTC_771 0250-0039 27.3 µM -0.593838688806884 0.325861515307638 no 2284 0.27631000481778 3413 3005115
SGTC_415 dibenzyl ketone 100 µM -0.593914010157792 0.325840786649333 no 2285 0.276284813975003 3483 7593
SGTC_3068 9116768 49.47 µM -0.595524244944379 0.325397774140997 no 2286 0.275746548840323 3499 41904888
SGTC_937 3122-0005 46.7 µM -0.597916576626207 0.324740044301028 no 2287 0.274947799278315 3525 759535
SGTC_3276 9139060 49.47 µM -0.598209116258493 0.324659653065729 no 2288 0.274850204691117 3548 4870619
SGTC_1296 1068-0102 11.9 µM -0.60258503507243 0.323458107078967 no 2289 0.273392389100273 3493 767053
SGTC_3213 9129884 49.47 µM -0.605796611490511 0.32257743685232 no 2290 0.272324910060539 3449 17190742
SGTC_345 1362-0200 395 µM -0.608071037564977 0.321954350745899 no 2291 0.271570180096632 3457 1419823
SGTC_322 k048-0136 19.3 µM -0.608394456444571 0.321865789719265 no 2292 0.271462943642215 3548 6823282
SGTC_2553 4-methylesculetin 85.09 µM -0.609630997038612 0.321527284060397 no 2293 0.271053136734379 3511 5319502
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.609925384563608 0.321446716662026 no 2294 0.270955618073321 3546 16623 A steroid.
SGTC_179 1273-0063 6.77 µM -0.61064194431603 0.321250645109647 no 2295 0.270718324040618 3472 3108139
SGTC_2229 7354935 190 µM -0.611908920318252 0.320904085614177 no 2296 0.270299009707374 3496 318112
SGTC_994 3910-0338 138 µM -0.612310707144488 0.320794216300132 no 2297 0.270166103467598 3587 3479481
SGTC_857 0438-0306 1.35 µM -0.612411946058675 0.320766534816141 no 2298 0.270132620011138 3578 4686136
SGTC_1985 st071382 65.5 µM -0.612543736174165 0.320730501292369 no 2299 0.270089035251642 3572 6123237
SGTC_294 k038-0071 157 µM -0.612905211266925 0.320631676895541 no 2300 0.269969508649033 3532 24152826
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.614446971614048 0.320210314771549 no 2301 0.269460002277736 3514 75037 A free radical scavenger.
SGTC_2315 7733312 200 µM -0.61470820508916 0.320138942773453 no 2302 0.269373720087441 3493 726316
SGTC_1199 1638-0010 4.46 µM -0.615163959142661 0.320014441443891 no 2303 0.26922322332431 3479 3111136
SGTC_1153 4055-0057 267 µM -0.615460887373389 0.319933338510576 no 2304 0.269125195904097 3471 882706
SGTC_1127 asiatic acid 681.4 nM -0.615817458090247 0.319835956210021 no 2305 0.269007501878612 3502 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1524 corynanthine 62.1 µM -0.618185686979986 0.319189489398085 no 2306 0.26822647192448 3575 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_13 0199-0087 65 µM -0.618503729347114 0.319102713650404 no 2307 0.268121670121159 3559 4589825
SGTC_3253 9135987 49.47 µM -0.618856373272635 0.319006508685116 no 2308 0.268005490459665 3543 4182430
SGTC_1635 st007035 42.4 µM -0.620358334275439 0.318596894555171 no 2309 0.267510948677659 3569 3716403
SGTC_1857 st056007 79.3 µM -0.620798737150796 0.318476830070547 no 2310 0.26736602713134 3568 619834
SGTC_2450 5739737 12.93 µM -0.623302782236169 0.317794529356636 no 2311 0.266542784911877 3550 2262825
SGTC_21 0849-0113 22.993 µM -0.624321690861526 0.31751707456177 no 2312 0.266208170805884 3530 1560156
SGTC_2493 resveratrol 26.09 µM -0.624533080682683 0.317459524704627 no 2313 0.266138776098078 3510 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_135 0933-0004 26.348 µM -0.626161549345279 0.317016329976429 no 2314 0.265604492303274 3539 21230617 YGL099W LSG1
SGTC_1627 st003713 25.6 µM -0.626945137813183 0.316803166476327 no 2315 0.265347598990266 3560 16195070 YER133W GLC7
SGTC_128 0906-2981 13.371 µM -0.62720298579096 0.316733036091216 no 2316 0.265263093145275 3553 6740226
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.627342694343844 0.316695040426486 no 2317 0.265217311449944 3544 6708784 An antioxidant flavonoid
SGTC_1383 3049-0032 20.7 µM -0.628244831103213 0.316449738487539 no 2318 0.264921783012126 3588 712864
SGTC_3268 9137683 49.47 µM -0.628672960553594 0.316333353130832 no 2319 0.264781591872526 3563 1953228
SGTC_1855 st056195 39.6 µM -0.629291911080944 0.316165125953478 no 2320 0.264578983006751 3554 4028379
SGTC_2922 7999257 32.47 µM -0.630904709537463 0.315726955459682 no 2321 0.264051416159497 3564 2988377
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.631956938261217 0.315441221926093 no 2322 0.26370750795167 3535 688664
SGTC_2082 5219693 150 µM -0.632193427694121 0.315377018214065 no 2323 0.263630245702177 3575 2834649
SGTC_2838 9002687 71.43 µM -0.632317023031235 0.315343465954023 no 2324 0.263589871099119 3537 6457060
SGTC_24 0417-1663 219 µM -0.633121662918176 0.315125068682663 no 2325 0.263327098399353 3566 4329390
SGTC_3043 9092303 49.47 µM -0.635799434350389 0.314398727187623 no 2326 0.262453578101372 3528 25236084
SGTC_2329 6138490 200 µM -0.636373837522528 0.314243014610447 no 2327 0.262266394512363 3561 720019
SGTC_1768 st044301 37.178 µM -0.636663036303287 0.314164629418935 no 2328 0.262172177771796 3548 3931349
SGTC_1802 st050112 57.9 µM -0.638925786408425 0.313551617294608 no 2329 0.261435605987585 3570 4662563
SGTC_1671 st016596 74.5 µM -0.639354653288608 0.313435488934229 no 2330 0.261296120868811 3607 2829167
SGTC_2830 7992007 71.43 µM -0.639675685278743 0.313348572152957 no 2331 0.261191733110158 3524 1952075
SGTC_3071 9117417 49.47 µM -0.640016133495141 0.313256409912441 no 2332 0.261081055329479 3504 45595590 YGL055W OLE1
SGTC_183 3914-0051 30.55 µM -0.641188369294487 0.312939164905481 no 2333 0.260700152632246 3570 1596232
SGTC_2883 9059145 45.46 µM -0.641624610582028 0.312821139211614 no 2334 0.260558474781791 3570 16476510
SGTC_641 4092-0595 30 µM -0.645252481131019 0.311840357855641 no 2335 0.259381790662037 3597 786260
SGTC_708 3448-5400 146 µM -0.646737538589825 0.311439262131422 no 2336 0.258900911805845 3578 3462195
SGTC_245 methotrexate 289.6 µM -0.647669502505478 0.311187664366708 no 2337 0.258599366780116 3574 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_977 1348-1378 135 µM -0.649492736325966 0.310695709913916 no 2338 0.258009969957064 3586 X977
SGTC_2136 5328288 199.296 µM -0.650885551508618 0.310320121115328 no 2339 0.257560184481598 3552 262395
SGTC_2647 atorvastatin 60.16 µM -0.651839241994211 0.310063061412158 no 2340 0.257252441752356 3587 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3315 9136395 68.55 µM -0.652022651962883 0.310013635346771 no 2341 0.257193279814155 3643 16876844
SGTC_1808 st050063 61.5 µM -0.652516543478547 0.309880556520534 no 2342 0.257034002063762 3599 4011993
SGTC_271 rotenone 740 µM -0.652654547103652 0.30984337596318 no 2343 0.256989505699981 3636 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_947 3447-0010 211 µM -0.655525600358045 0.309070306300367 no 2344 0.256064704692771 3620 748350
SGTC_1553 gossypol 38.6 µM -0.655707871407986 0.309021255854891 no 2345 0.256006051636833 3546 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2117 5521686 200 µM -0.656077912354266 0.308921685658919 no 2346 0.255886997611334 3595 803312
SGTC_1911 st060208 74.3 µM -0.656409501210674 0.30883247403445 no 2347 0.255780339405891 3606 688783
SGTC_929 2805-0021 398 µM -0.658096873655526 0.308378673281319 no 2348 0.255237942324949 3622 3098024
SGTC_2572 astragaloside iv 100 µM -0.659165225589057 0.308091502712721 no 2349 0.254894837332376 3622 45006101 An anti-inflammatory agent.
SGTC_51 1013-0126 23.419 µM -0.661481542640939 0.307469285499009 no 2350 0.25415177377653 3696 1627850
SGTC_1792 st045773 43.6 µM -0.661666627481508 0.3074195912221 no 2351 0.254092448489023 3567 2919270
SGTC_1202 1988-0068 29.6 µM -0.663016173023845 0.307057352457103 no 2352 0.253660098016464 3554 2850480
SGTC_1085 doxorubicin 7.67 µM -0.663503703439749 0.30692653806544 no 2353 0.253504004191504 3634 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3203 9113543 49.47 µM -0.665327530971387 0.306437385858051 no 2354 0.252920512656509 3635 17018012
SGTC_3016 9080866 49.47 µM -0.666944519271842 0.306003996344543 no 2355 0.252403786307687 3620 17066299
SGTC_984 1492-0255 2.91 µM -0.667584518397598 0.305832537016451 no 2356 0.252199421371483 3564 1585198
SGTC_158 k038-0087 26.446 µM -0.668833937889334 0.305497933218881 no 2357 0.251800707533987 3585 X158
SGTC_1575 cyproterone acetate 48 µM -0.670758932582269 0.304982723283106 no 2358 0.251187056609772 3583 9880 An androgen receptor antagonist and liver toxin.
SGTC_95 0471-0001 561.058 µM -0.671680344207418 0.304736251242413 no 2359 0.250893608620448 3568 4015405
SGTC_1966 st070145 16.1 µM -0.672633976318055 0.30448125371321 no 2360 0.250590090355181 3587 3748532
SGTC_1628 st004252 77.7 µM -0.674493129980201 0.303984396457725 no 2361 0.24999892598501 3617 692968
SGTC_1290 0986-0249 10.2 µM -0.675171464695323 0.303803202122539 no 2362 0.249783416916949 3593 53329
SGTC_3088 9117578 49.47 µM -0.677946307223637 0.303062498399393 no 2363 0.248902868770052 3695 678341
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.682700097587275 0.301795424989458 no 2364 0.247398184028411 3728 688801
SGTC_2598 perillyl alcohol 100 µM -0.682950646208248 0.301728709961599 no 2365 0.247319014679237 3651 10819 An apoptosis inducer.
SGTC_1232 0279-0259 161 µM -0.684698635267027 0.301263447445058 no 2366 0.24676705520558 3675 1560000
SGTC_1669 st015249 58.4 µM -0.685101926400975 0.301156149272243 no 2367 0.246639802364273 3719 722793
SGTC_18 0111-0177 500 nM -0.68992914578764 0.299873175658625 no 2368 0.245119373026298 3741 721752
SGTC_1732 st034308 51.822 µM -0.69033361589309 0.299765788421067 no 2369 0.24499220635091 3584 830119
SGTC_2505 galangin 7.89 µM -0.692453291254377 0.299203297394922 no 2370 0.244326354539944 3595 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_258 haloperidol 50.781 µM -0.69704631328674 0.297986109240028 no 2371 0.242886905296682 3675 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2426 5582046 32.21 µM -0.698261253123007 0.297664518169126 no 2372 0.242506913041395 3670 2251934
SGTC_1697 st025554 27.742 µM -0.698394538773477 0.297629247484246 no 2373 0.242465245388647 3650 1269519
SGTC_2335 9018011 154.17 µM -0.699258098306555 0.297400774466062 no 2374 0.242195374088756 3704 6458208
SGTC_1040 k898-0338 155 µM -0.699499462104643 0.297336930873379 no 2375 0.242119974527404 3701 20969351
SGTC_2395 5646831 180.19 µM -0.70040111495929 0.297098488383785 no 2376 0.241838420084853 3673 6808628
SGTC_4 0960-0234 25.671 µM -0.703946813611749 0.296161675923664 no 2377 0.240732948204528 3666 6821112
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.705306152941764 0.295802883301258 no 2378 0.24030986609968 3712 279621
SGTC_1838 st055369 84.5 µM -0.705457859260501 0.295762853364737 no 2379 0.240262674018005 3663 676036
SGTC_1666 st014829 29 µM -0.706903288193829 0.295381580637551 no 2380 0.239813290214889 3713 3858230
SGTC_2744 captopril 92.04 µM -0.706992398404349 0.295358082703243 no 2381 0.239785600867619 3656 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3355 9151058 44.0485 µM -0.707257609559394 0.295288152885742 no 2382 0.239703201735865 3700 17015728
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.708551803917106 0.294947014259406 no 2383 0.239301326951664 3745 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_133 0724-0033 378.92 µM -0.709843036928889 0.294606837307512 no 2384 0.238900738816299 3589 280309
SGTC_2807 7945238 51.95 µM -0.71077811818183 0.29436060204016 no 2385 0.23861087120166 3716 17148797
SGTC_1111 tnp00062 510.699 nM -0.711364979506351 0.294206112198193 no 2386 0.238429047302177 3748 676306
SGTC_704 1310-0270 142 µM -0.71182583695236 0.294084818840976 no 2387 0.238286315663098 3671 5718033
SGTC_2818 7996756 12.99 µM -0.712066785948329 0.294021412527354 no 2388 0.238211710257438 3704 2241621
SGTC_959 1222-0044 107 µM -0.712165219982163 0.293995511190662 no 2389 0.238181235659494 3659 6083612
SGTC_1757 st041620 31.8375 µM -0.712332181851863 0.293951580265835 no 2390 0.238129550131404 3728 5289815
SGTC_2787 5284540 71.43 µM -0.712622869144123 0.293875102012769 no 2391 0.238039578227277 3714 736958
SGTC_1345 1488-0192 31.4 µM -0.713755845617203 0.293577109912231 no 2392 0.237689083589901 3709 658348
SGTC_62 0180-0423 3.232 µM -0.715168758299513 0.293205685981554 no 2393 0.23725238561621 3671 30102 YGL099W LSG1
SGTC_1097 itavastatin 7.23 µM -0.715814970755146 0.293035883458634 no 2394 0.237052803555706 3717 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_928 2764-0428 58.7 µM -0.715957447737285 0.292998451521329 no 2395 0.237008812101525 3741 662578
SGTC_3322 9139058 2.11 µM -0.716557116468028 0.292840929257224 no 2396 0.236823706478073 3774 4908926 YPR165W RHO1
SGTC_1839 st053978 48 µM -0.716987620759051 0.292727867717911 no 2397 0.236690867534987 3741 3788398
SGTC_963 1269-2853 151 µM -0.719320980545556 0.292115420202171 no 2398 0.235971585864911 3712 3668223
SGTC_2914 7968218 45.32 µM -0.720170177600101 0.291892675707641 no 2399 0.235710111600258 3670 2977111
SGTC_259 usnic acid 108.925 µM -0.720295531789075 0.291859801989906 no 2400 0.235671527625589 3782 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2725 haloperidol 53.21 µM -0.720840012572009 0.291717033739359 no 2401 0.235503977066269 3672 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_405 ebelactone b 50 µM -0.722424774677964 0.291301678770687 no 2402 0.235016679797482 3703 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2991 9074669 71.4286 µM -0.722497745153592 0.291282560372755 no 2403 0.234994255585963 3685 17333109
SGTC_2556 citropten 84.59 µM -0.723441617162234 0.291035316981 no 2404 0.234704305311175 3745 2775 A potential DNA crosslinker.
SGTC_1645 Cervolide 78 µM -0.725462320492458 0.290506331927006 no 2405 0.234084226260218 3672 23173 A fragrance.
SGTC_1324 1418-0026 34.4 µM -0.726227039296561 0.290306259254129 no 2406 0.233849799223475 3762 1372513
SGTC_1227 3909-8010 46.6 µM -0.726296678002226 0.290288042950338 no 2407 0.233828457716693 3706 15982272
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.726695977014716 0.29018360344071 no 2408 0.233706109214519 3660 140250 A respiratory chain inhibitor.
SGTC_943 3253-1379 105 µM -0.728481053628077 0.289716919311317 no 2409 0.233159581240203 3704 668464
SGTC_909 3448-9333 149 µM -0.729263297361866 0.289512523320976 no 2410 0.232920309354424 3672 3344074
SGTC_2670 beta-carotene 100 µM -0.730835431287999 0.289101938306929 no 2411 0.232439839472559 3646 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_38 0929-0051 58.268 µM -0.733235181428925 0.288475738161607 no 2412 0.231707500551645 3738 1379719
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.734312663247989 0.288194783954411 no 2413 0.231379100902732 3734 1273210
SGTC_1180 1193-0155 285 µM -0.738745594473359 0.287040253843425 no 2414 0.230030746949302 3734 2921347
SGTC_2753 fluvastatin 17.09 µM -0.739806575546723 0.286764252959562 no 2415 0.229708684270728 3765 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2193 5925765 200 µM -0.741639348358235 0.286287776738676 no 2416 0.229152938219745 3730 877370
SGTC_856 0433-0016 11.3 µM -0.741953114864017 0.286206242801649 no 2417 0.229057871425918 3780 3911780
SGTC_162 k030-0015 37.8 µM -0.742442177367715 0.286079179239644 no 2418 0.228909736563692 3795 1809920 YMR134W ERG29
SGTC_2710 st078562 53.7235 µM -0.742932030449536 0.285951937151262 no 2419 0.228761416147437 3719 17250908
SGTC_331 k048-0133 24.5 µM -0.743420699928568 0.285825029320821 no 2420 0.228613507881566 3720 6813582
SGTC_56 0957-0365 83.25 µM -0.743930931232667 0.285692550457682 no 2421 0.228459130711721 3698 6752360
SGTC_2502 avocadyne acetate 18.59 µM -0.743974537062414 0.28568122978944 no 2422 0.228445939913492 3718 3952079
SGTC_716 1683-5115 658 µM -0.744234956747025 0.285613625730578 no 2423 0.228367171660918 3753 723597
SGTC_1397 3532-0190 20.1 µM -0.744271377531515 0.28560417162642 no 2424 0.228356156807281 3664 5322280
SGTC_3286 9117135 37.221 µM -0.744443701695779 0.285559441753883 no 2425 0.228304044311 3735 3438150
SGTC_112 phenothiazine 287.218 µM -0.745102822752495 0.285388385663921 no 2426 0.228104781409099 3715 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2652 actinonin 100 µM -0.746327998018152 0.285070556052088 no 2427 0.227734651189294 3725 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_538 2922-0838 53.3 µM -0.74697400094373 0.284903040770842 no 2428 0.227539627383108 3752 777039
SGTC_869 0564-0080 44.1 µM -0.747168069419082 0.284852725969122 no 2429 0.227481057831593 3780 6843321
SGTC_1349 flufenamic acid 69 µM -0.748605439609102 0.28448020090404 no 2430 0.227047526271709 3712 3371 A non-steroidal anti-inflammatory.
SGTC_2649 anisomycin 9.56 µM -0.74915009770519 0.284339101996004 no 2431 0.226883371328685 3741 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2379 9035213 200 µM -0.750895248215623 0.283887229413075 no 2432 0.226357850150975 3741 646551
SGTC_2101 5377231 179.231 µM -0.753712967580867 0.28315836245035 no 2433 0.225510796793227 3790 2844213
SGTC_2972 9093619 59.92 µM -0.754846039610976 0.282865521024702 no 2434 0.225170682916648 3782 25236256
SGTC_297 0986-0032 24 µM -0.755268348945328 0.282756412785246 no 2435 0.225043992829489 3744 2847425
SGTC_2870 9038528 12.99 µM -0.755722889858271 0.28263899976256 no 2436 0.224907678621385 3736 6463316
SGTC_1826 st055655 41.6 µM -0.756195563876299 0.282516927614327 no 2437 0.22476597605503 3808 676168
SGTC_9 0092-0002 10.449 µM -0.75656022992918 0.282422766782459 no 2438 0.224656687714647 3745 759368
SGTC_1652 st011932 78 µM -0.757817943308219 0.282098127050209 no 2439 0.224279989507649 3714 1551076
SGTC_911 3456-4043 236 µM -0.759823590658525 0.281580803359543 no 2440 0.223680019856146 3851 914281
SGTC_2434 5670830 169.91 µM -0.760131650511187 0.28150138495082 no 2441 0.223587947701053 3799 1549830
SGTC_3252 9135871 49.47 µM -0.76222766088175 0.280961316619223 no 2442 0.222962069898224 3784 17682838
SGTC_1374 2889-5571 141 µM -0.763731710874897 0.280574084544038 no 2443 0.222513569678701 3809 2853281
SGTC_2116 5511452 16.8835 µM -0.76453522374504 0.280367318351458 no 2444 0.22227417712699 3806 870744
SGTC_913 3487-1245 167 µM -0.767319396418485 0.279651444645507 no 2445 0.221445819436738 3743 4016153
SGTC_1017 4239-0030 168 µM -0.767333790398538 0.279647745934319 no 2446 0.221441541475783 3831 1149593
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.767725031492434 0.279547220791285 no 2447 0.221325280815197 3799 165521
SGTC_2806 7952793 58.44 µM -0.768120510747097 0.279445624532915 no 2448 0.221207796233508 3813 2972490
SGTC_1617 st002906 78 µM -0.769469770939892 0.279099142667781 no 2449 0.220807241601237 3799 5150859
SGTC_2743 auranofin 4.32 µM -0.77071832080536 0.278778708795702 no 2450 0.220436955086606 3732 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2603 homopterocarpin 100 µM -0.771096952752602 0.278681570259541 no 2451 0.220324733340492 3837 101795 A weak amylase inhibitor.
SGTC_289 k017-0060 526 µM -0.77150787069612 0.278576167358348 no 2452 0.220202979500367 3778 5512909
SGTC_2600 tangeritin 87.95 µM -0.77200150051859 0.278449574044915 no 2453 0.220056769389256 3741 68077 A bioactive flavone.
SGTC_862 0452-0056 10.2 µM -0.773319106770815 0.278111806055724 no 2454 0.219666775375663 3735 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.775209637854276 0.27762751831984 no 2455 0.219107897034362 3790 6857784
SGTC_1473 k844-0725 134 µM -0.777558850650561 0.277026307057823 no 2456 0.218414563829448 3858 54682906
SGTC_1661 st013063 9.66 µM -0.784340372453002 0.275294361371761 no 2457 0.216420208005852 3844 721395
SGTC_1014 4130-3005 69.3 µM -0.784978883789283 0.27513156568273 no 2458 0.216232974688759 3821 743608
SGTC_3236 9132701 49.47 µM -0.78562945410162 0.274965744195128 no 2459 0.216042301764265 3818 24282524
SGTC_1157 4092-0394 27.6 µM -0.78700530617365 0.274615220559464 no 2460 0.215639379990856 3914 3659885
SGTC_881 0833-0569 170 µM -0.787466102436423 0.274497873521319 no 2461 0.215504532096411 3825 5418700
SGTC_2206 7254556 146.969 µM -0.789440468216754 0.273995359000349 no 2462 0.214927305666537 3823 4398905
SGTC_20 0481-0013 4.944 µM -0.789538039544812 0.273970536992491 no 2463 0.214898802975476 3834 182045
SGTC_1308 1187-1617 41.4 µM -0.790348869088131 0.273764306108544 no 2464 0.21466202711029 3805 2882570
SGTC_1102 cgs 12066b 26.1 µM -0.79046400746904 0.273735027400611 no 2465 0.214628417064136 3826 6438352 A 5-HT1B full agonist.
SGTC_3021 9087658 49.47 µM -0.791719474630617 0.273415873368428 no 2466 0.214262132183347 3758 25237042
SGTC_269 exalamide 29 µM -0.791795740680288 0.273396491608692 no 2467 0.214239893143571 3775 3316 A derivative of salicylamide.
SGTC_785 1270-0111 65.3 µM -0.793638218637936 0.27292846304455 no 2468 0.213703038180831 3793 6741994
SGTC_2893 9048488 25.97 µM -0.793826264294894 0.272880717804193 no 2469 0.213648290181826 3854 6467338
SGTC_1725 st036284 20.55 µM -0.794050290302806 0.272823842474644 no 2470 0.213583077456486 3914 707914
SGTC_613 3914-0030 117 µM -0.794510609970042 0.272706995783271 no 2471 0.213449117365959 3573 1145395
SGTC_849 0386-0493 241 µM -0.795529884265634 0.272448353488309 no 2472 0.213152667228939 3783 726119
SGTC_2794 7785382 27.27 µM -0.796274584611196 0.272259461770849 no 2473 0.212936227268136 3763 2205081
SGTC_2504 purpurogallin 52.29 µM -0.79729983116575 0.271999516595552 no 2474 0.212638459188529 3753 5281571 An antioxidant.
SGTC_2327 6189656 200 µM -0.798002192357763 0.271821508356424 no 2475 0.212434608933306 3906 5349088
SGTC_2306 7482397 179.52 µM -0.798604281884793 0.27166895938687 no 2476 0.212259952015088 3811 891448
SGTC_523 1934-0222 13.7 µM -0.799646590269538 0.27140497475516 no 2477 0.211957792869017 3822 1361595
SGTC_540 1187-0821 17.3 µM -0.800040114112265 0.271305340524992 no 2478 0.21184377805039 3786 847520
SGTC_1982 st072467 71.9 µM -0.800554097638511 0.271175235201292 no 2479 0.211694916757996 3818 3163533
SGTC_1337 1486-1011 40.3 µM -0.800597556230695 0.271164235897414 no 2480 0.211682332971235 3828 X1337
SGTC_1234 0326-0494 15.5 µM -0.801196508913058 0.271012664544673 no 2481 0.211508945981069 3898 1547813
SGTC_336 4111-0029 111 µM -0.802625751456464 0.270651150342452 no 2482 0.211095539799947 3822 3131175
SGTC_2367 9070478 135.38 µM -0.809020944235219 0.269036498663113 no 2483 0.209251549591636 3805 572802
SGTC_2344 7990960 76.95 µM -0.810630771635817 0.268630814108256 no 2484 0.208788870032687 3827 140813
SGTC_871 0574-0004 149 µM -0.812293177907181 0.268212202299584 no 2485 0.208311712090379 3830 9551173
SGTC_677 0929-0063 136 µM -0.812454806708298 0.268171519940718 no 2486 0.208265354359589 3818 1539583
SGTC_511 blebbistatin 171 µM -0.813814190563129 0.267829482681805 no 2487 0.207875702211779 3915 3476986 A myosin inhibitor.
SGTC_475 α-linolenic acid 10 µM -0.814700372415147 0.267606627103418 no 2488 0.207621920073496 3877 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2233 sulbentine 40.3845 µM -0.81514522410301 0.267494791771036 no 2489 0.207494593806783 3830 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1076 itraconazole 331 nM -0.815660089131926 0.267365384575366 no 2490 0.207347285825859 3847 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1565 sinapyl alcohol 95.1 µM -0.816370725995987 0.267186823591794 no 2491 0.207144067185269 3884 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1114 scopoletin 1.73284 µM -0.816507410534684 0.267152485913702 no 2492 0.207104993441605 3850 5280460 A coumarin with genotoxic properties.
SGTC_1138 3761-0006 1.03 µM -0.818513660334481 0.266648735394466 no 2493 0.206531972558944 3820 12061087
SGTC_1981 st071826 47 µM -0.81873399110419 0.266593441683793 no 2494 0.206469099428215 3893 11838600
SGTC_2769 toremifene 3.73 µM -0.819407443206099 0.266424469621864 no 2495 0.206276994847325 3849 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1150 3909-7983 10.9 µM -0.82038899898462 0.266178290079655 no 2496 0.205997192416719 3848 23965914
SGTC_2167 5876490 200 µM -0.820730035783325 0.266092783157162 no 2497 0.205900029134031 4023 686534
SGTC_2312 7706453 155.7 µM -0.821918374759922 0.265794943948876 no 2498 0.205561677221351 3888 976098
SGTC_793 0488-0545 106 µM -0.82502259577545 0.265017715917082 no 2499 0.204679381222136 3863 292548
SGTC_432 NS 1619 61.3 µM -0.825846528606572 0.26481161551297 no 2500 0.204445578109894 3932 4552 A K+/calcium channel activator.
SGTC_1895 st058434 18.3 µM -0.82728095447297 0.264452999530429 no 2501 0.204038918057121 3890 5393175
SGTC_1621 st003705 32.4 µM -0.83059580550237 0.263625211387797 no 2502 0.203101002549379 3912 24207032
SGTC_2817 7995342 71.43 µM -0.833307202079698 0.262949102782382 no 2503 0.202335747754571 3882 18879975
SGTC_430 0958-0115 16.4 µM -0.833486232838273 0.262904491236665 no 2504 0.202285279523594 3851 6833180
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.834624559764643 0.262620929281899 no 2505 0.201964564772157 3920 4174840
SGTC_742 0kpi-0133 140 µM -0.836675706307952 0.262110375544073 no 2506 0.201387439099306 3948 2728852
SGTC_50 0929-0078 56.389 µM -0.837898316473072 0.261806296092851 no 2507 0.20104390718712 3770 1377751
SGTC_840 0245-0196 390 µM -0.838601085724347 0.261631589945791 no 2508 0.200846600602998 3986 3827528
SGTC_2047 4141938 200 µM -0.839478217228308 0.261413621882352 no 2509 0.200600503885909 3884 3807862
SGTC_6 0844-0013 19.835 µM -0.840685109753518 0.261113860381601 no 2510 0.200262182252046 3998 1584900
SGTC_591 4299-0174 154 µM -0.843182628579433 0.260494101624469 no 2511 0.199563156124849 3878 5509088
SGTC_2085 5307070 144.047 µM -0.843603950829138 0.260389625319193 no 2512 0.19944537790965 3849 2840351
SGTC_2485 5633444 17.78 µM -0.847384368825325 0.259453152479857 no 2513 0.198390457108227 3925 5724239
SGTC_2662 daunorubicin 22.37 µM -0.851384856994887 0.258464062399335 no 2514 0.19727780042189 3798 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3009 9080819 71.4286 µM -0.853575172924911 0.257923352179715 no 2515 0.196670209762949 3924 17027216
SGTC_1986 st071812 45 µM -0.85410498314536 0.257792649295447 no 2516 0.196523411557448 3851 11838594
SGTC_1242 0402-0103 60.1 µM -0.856152508209427 0.257287853200344 no 2517 0.195956713921837 3852 432868
SGTC_121 0557-0495 61.343 µM -0.857408220828179 0.256978524619158 no 2518 0.195609658783672 4049 3104427
SGTC_3190 9110366 49.47 µM -0.857554337648614 0.256942543198438 no 2519 0.195569299121053 3902 17123768
SGTC_1866 st057638 64 µM -0.858216197144422 0.256779592434866 no 2520 0.195386546911817 3887 688802
SGTC_3227 9130768 49.47 µM -0.858594875153918 0.256686385560984 no 2521 0.195282033260468 3932 17720899
SGTC_2363 9053361 176 µM -0.858970774251837 0.256593880106822 no 2522 0.19517832017988 3977 6469797 YMR079W SEC14
SGTC_1125 tnp00248 1.32998 µM -0.859650356237517 0.256426685050564 no 2523 0.194990903940893 4016 24207736
SGTC_1340 1486-1359 257 µM -0.859744072255972 0.256403632897921 no 2524 0.194965067370485 3855 4309068
SGTC_1094 duloxetine 25.4 µM -0.860265321759583 0.256275436286249 no 2525 0.194821402076722 3915 60834 A selective serotonin reuptake inhibitor.
SGTC_619 1652-1634 108 µM -0.860721950623378 0.256163159999732 no 2526 0.194695600262921 3882 5400454
SGTC_694 1315-0438 43.2 µM -0.860869186500305 0.256126962988769 no 2527 0.194655047136952 3882 6793154
SGTC_1273 0849-0096 14.1 µM -0.862585164537465 0.255705297403501 no 2528 0.194182794989426 3940 5286025
SGTC_2387 9077560 195.08 µM -0.86360920935009 0.255453832693238 no 2529 0.193901301689612 3898 5303272
SGTC_317 4495-0002 170 µM -0.868853296186683 0.254168121336226 no 2530 0.192463688812095 3965 15991618
SGTC_2941 9056145 11.23 µM -0.869156747355544 0.254093827145304 no 2531 0.192380700705284 3784 2119517
SGTC_2697 mebhydrolin 72.4 µM -0.869637009230198 0.253976267533918 no 2532 0.192249402970914 3989 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3159 9100096 49.47 µM -0.870125643611653 0.253856687778136 no 2533 0.192115872562942 3897 25236875
SGTC_749 1000-0129 128 µM -0.870575939292013 0.253746516530999 no 2534 0.191992869328769 3987 708470
SGTC_623 k072-0108 16.9 µM -0.870689450329897 0.253718748402462 no 2535 0.191961870144064 3910 5382803
SGTC_2072 5231554 129 µM -0.872223063602528 0.253343738094447 no 2536 0.191543349889999 3985 789545
SGTC_1400 3771-8998 51.5 µM -0.872957686365519 0.25316420604422 no 2537 0.19134307084883 3846 670767
SGTC_950 1165-0508 94.1 µM -0.873221018769513 0.253099867396158 no 2538 0.191271310212515 3962 6148369
SGTC_1294 1000-1494 117 µM -0.874601959527143 0.252762610133765 no 2539 0.19089526060976 3928 712797 YDL207W GLE1
SGTC_1682 st012968 530 nM -0.875697596235582 0.252495199073232 no 2540 0.190597226235303 3947 24207270
SGTC_1248 0469-0687 58.6 µM -0.877308972191633 0.252102183013071 no 2541 0.190159420116089 3948 4017482
SGTC_2842 9000675 19.48 µM -0.878379069147637 0.251841363813674 no 2542 0.189869019637792 4002 2989072
SGTC_2168 5727979 200 µM -0.880955650053325 0.251213947876462 no 2543 0.189170912459788 3850 695210
SGTC_776 4476-4378 112 µM -0.881756631784665 0.251019071640422 no 2544 0.188954214330289 4001 2892008
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.883257492423675 0.25065413262791 no 2545 0.188548582441445 3891 279621
SGTC_3121 9125696 49.47 µM -0.885558861130678 0.250095093828243 no 2546 0.187927644078758 4025 1235365
SGTC_3001 9076041 71.4286 µM -0.886916808886451 0.249765537430286 no 2547 0.187561845615049 3936 16004211
SGTC_1318 1280-3875 124 µM -0.887064089196971 0.249729808265105 no 2548 0.187522198305786 3973 373245
SGTC_2385 9074692 200 µM -0.888246347851135 0.249443099016048 no 2549 0.18720412637249 3979 17046906
SGTC_2506 ethyl hematommate 54.16 µM -0.888964559853258 0.249269011057722 no 2550 0.187011063397877 4040 3940691 An allergen.
SGTC_2095 5432005 200 µM -0.890204025085953 0.248968728138521 no 2551 0.186678171885462 3969 783734
SGTC_1749 st037932 54.2 µM -0.890710543534705 0.248846070293675 no 2552 0.186542238476748 4019 594497
SGTC_2524 avocatin b 10.57 µM -0.892474773203235 0.248419098019041 no 2553 0.186069254206976 3917 6710748
SGTC_1519 esterone 74 µM -0.894674782128642 0.24788720759557 no 2554 0.185480481518749 3939 698 A steroid.
SGTC_2661 dactinomycin 12.96 µM -0.895820811016234 0.247610376162422 no 2555 0.185174236574981 3945 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3320 9137005 35.139 µM -0.895907860538239 0.247589355481131 no 2556 0.185150987805901 3985 4908713
SGTC_2296 7971656 126.45 µM -0.898892211384217 0.246869272631732 no 2557 0.184355038488331 4017 666570
SGTC_2877 9040724 71.43 µM -0.899290237086897 0.246773319291733 no 2558 0.184249043105647 3942 6463895
SGTC_2342 7990637 118.86 µM -0.899753715924972 0.246661612120921 no 2559 0.184125665169115 4040 2033102 YER133W GLC7
SGTC_2910 7948405 25.97 µM -0.903987644939543 0.245642409958785 no 2560 0.183000976372355 3875 2971328
SGTC_1389 3405-0187 19 µM -0.904573521195206 0.245501554687418 no 2561 0.182845684191972 3949 799890
SGTC_76 0433-0009 400.328 µM -0.905772944256614 0.245213327047554 no 2562 0.182528022135136 4085 2841569
SGTC_559 1550-0661 158 µM -0.905891266741105 0.245184903398198 no 2563 0.182496703622483 4028 5830875
SGTC_1797 st048695 56.8 µM -0.907339367985903 0.244837181364479 no 2564 0.18211368091521 3961 592262 YIL048W NEO1
SGTC_668 1682-0499 62.6 µM -0.908904594161674 0.244461633667431 no 2565 0.181700244266011 3980 682214
SGTC_1710 st031758 61.5 µM -0.909498512449427 0.244319214988803 no 2566 0.181543521334452 4011 5394341
SGTC_2236 dapsone 200 µM -0.910185841170399 0.244154452788039 no 2567 0.181362254941154 3976 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2567 aureobasidin a 60 nM -0.910430251250099 0.244095878755405 no 2568 0.181297824992517 4150 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2205 7238770 200 µM -0.910932279325132 0.243975589125111 no 2569 0.181165528266254 4041 279867
SGTC_2084 5306078 60.6385 µM -0.911423755124764 0.243857858883697 no 2570 0.181036070917175 3931 679340
SGTC_2210 7115885 190.385 µM -0.912014360805183 0.243716423209036 no 2571 0.180880578925265 4027 2927039
SGTC_1780 st038448 24.544 µM -0.913909622156133 0.243262853516579 no 2572 0.180382168608511 4048 728868 YDL195W SEC31
SGTC_1004 4084-0029 199 µM -0.914510535279473 0.243119139662064 no 2573 0.180224322304386 4011 716894 YLR208W SEC13
SGTC_1910 st062352 60.4 µM -0.914894695090734 0.243027288401556 no 2574 0.18012345763918 3918 2245730
SGTC_730 1436-0052 41.2 µM -0.914976399924163 0.24300775548385 no 2575 0.180102009860124 4001 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_578 3460-0051 92 µM -0.915224052161812 0.242948555229992 no 2576 0.180037010153978 4064 2876744
SGTC_1451 4152-0210 104 µM -0.916008353809007 0.242761122622868 no 2577 0.179831256695716 3974 659563
SGTC_2110 5483698 200 µM -0.916036330681442 0.242754438148834 no 2578 0.179823919980785 3972 2848765 YHR062C RPP1
SGTC_3057 9095946 49.47 µM -0.916109698455329 0.242736908964985 no 2579 0.179804680751738 4010 24540043
SGTC_3093 9117344 49.47 µM -0.919187955207 0.242002063149325 no 2580 0.178998635047611 4044 24824913
SGTC_3206 9114350 49.47 µM -0.920063106248068 0.241793366343635 no 2581 0.178769891294881 3917 17087243
SGTC_689 0833-0039 98 µM -0.920763178907564 0.241626490726217 no 2582 0.178587041428087 3963 5374726
SGTC_1946 st076057 65.1 µM -0.921149762400704 0.241534368011202 no 2583 0.178486121347351 3901 953009
SGTC_2057 5236571 38.335 µM -0.921666716583918 0.24141120781745 no 2584 0.178351223319561 3990 54684039 YBR257W POP4
SGTC_1931 st074438 57.1 µM -0.922218190249571 0.241279861250551 no 2585 0.178207388348462 3965 2787313
SGTC_572 0960-0087 17.7 µM -0.923021802645216 0.24108853139647 no 2586 0.177997921666269 3981 6796365
SGTC_419 nsc-638432 893 µM -0.923952436644735 0.24086706243827 no 2587 0.177755540075606 3974 368090
SGTC_99 0109-0120 622.8 µM -0.925217306663052 0.240566230712364 no 2588 0.177426441440615 3979 759414
SGTC_303 1348-1668 34.2 µM -0.925441840127677 0.240512849941486 no 2589 0.177368061706222 4007 5380509
SGTC_3204 9114183 49.47 µM -0.926704217040995 0.240212851520974 no 2590 0.177040063712325 4007 17027248
SGTC_1128 3448-9350 235 µM -0.929513419212601 0.23954598920994 no 2591 0.176311537045999 4062 619386
SGTC_732 3970-1727 52.7 µM -0.930228586240465 0.239376380868375 no 2592 0.176126372004448 4069 1275699
SGTC_3062 9077494 49.47 µM -0.931800540428377 0.239003808327092 no 2593 0.175719807652219 4001 16459633
SGTC_3017 9080681 49.47 µM -0.935325289664162 0.238169552906258 no 2594 0.174810343014625 4028 16451914
SGTC_3048 9093155 49.47 µM -0.935812583354714 0.238054343451404 no 2595 0.174684845764111 3963 25236002
SGTC_1747 st037496 66.6 µM -0.936630956129363 0.23786092665927 no 2596 0.174474211389257 4018 723305
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.93739008842368 0.237681588021023 no 2597 0.17427896873467 4001 16486 A toxic proline analog.
SGTC_1649 st011737 51.3 µM -0.937473030940444 0.237661998043432 no 2598 0.174257645009706 4002 1761035
SGTC_2443 5493264 126.67 µM -0.937595737722151 0.237633017872221 no 2599 0.174226101314732 4049 5340055
SGTC_1257 0669-0121 16 µM -0.939674216334794 0.237142429634792 no 2600 0.173692347290443 4030 4307855
SGTC_1031 k035-0009 16 µM -0.939804081201247 0.237111795803067 no 2601 0.173659032513392 4089 5180959
SGTC_1183 1254-0324 198 µM -0.940183385021415 0.237022334251505 no 2602 0.173561751398653 4094 5799357
SGTC_554 4483-2211 187 µM -0.94214403834232 0.236560195878118 no 2603 0.173059450215571 4063 747107
SGTC_2351 9026858 72.31 µM -0.942220983649777 0.236542069499455 no 2604 0.173039756444401 3936 1409300
SGTC_2301 7769476 200 µM -0.94251480087604 0.23647286058463 no 2605 0.172964568512439 4070 977820
SGTC_1708 st033234 31.827 µM -0.943885102619862 0.236150232004022 no 2606 0.17261418278389 4118 674664
SGTC_2650 prasterone 100 µM -0.944601372778897 0.235981687423184 no 2607 0.172431212962027 4003 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2665 lovastatin 100 µM -0.944614820003978 0.235978523808579 no 2608 0.172427779077931 4045 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_820 1582-0060 59.9 µM -0.947058478669765 0.235404013163529 no 2609 0.171804490508173 4051 3848840
SGTC_3224 9130643 49.47 µM -0.947219225471547 0.235366248242904 no 2610 0.171763540339412 4076 17644395
SGTC_2118 5526350 200 µM -0.948795023150482 0.234996216609333 no 2611 0.171362436803485 4074 743594
SGTC_3295 9122362 53.5725 µM -0.949340426011371 0.234868219046961 no 2612 0.171223749552036 4077 4730473
SGTC_222 nsc-310342 10.666 µM -0.9502262623435 0.234660409187066 no 2613 0.170998648489096 3991 432556
SGTC_2366 9070441 60.58 µM -0.951579096066816 0.234343241911942 no 2614 0.170655243583876 4035 6837235
SGTC_2903 5923464 63.88 µM -0.957216211184749 0.233024196750097 no 2615 0.169229068150975 4047 2876576
SGTC_1579 chlormadinone acetate 49.4 µM -0.960947934744898 0.23215327288619 no 2616 0.168289173594206 4081 45114258 A steroidal progestin.
SGTC_3179 9107801 49.47 µM -0.967077676984651 0.230726630363532 no 2617 0.166752601978269 4054 4818259
SGTC_2036 5160441 105 µM -0.970611372355431 0.229906425015043 no 2618 0.165870920347497 4029 134534 YIL048W NEO1
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.971573318986283 0.229683430727423 no 2619 0.165631430682255 4095 6708561
SGTC_659 k018-0002 107 µM -0.971823567487613 0.229625439070439 no 2620 0.165569164593002 4069 6797879 YHR007C ERG11
SGTC_553 k007-0256 45.7 µM -0.971837524603374 0.229622204941845 no 2621 0.165565692270669 4108 6287000
SGTC_3353 9151644 39.2805 µM -0.973644884557879 0.229203620994143 no 2622 0.165116446008827 4096 4909158
SGTC_44 0929-0055 61.211 µM -0.976475227910259 0.228548974999103 no 2623 0.164414508976173 3973 1379590
SGTC_657 3534-0529 86.7 µM -0.976913629191036 0.228447668729186 no 2624 0.164305956889406 4123 1049549
SGTC_2894 9048625 32.47 µM -0.97748445479656 0.228315799515013 no 2625 0.164164685014312 4041 4092861
SGTC_2586 curcumin 80 µM -0.981238608300873 0.22744960086223 no 2626 0.163237544582014 4016 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2026 5148700 152 µM -0.985343142647931 0.226504680425033 no 2627 0.162227773885872 4040 79838
SGTC_728 3030-5151 22.5 µM -0.985982641392847 0.226357658811623 no 2628 0.162070815540134 4118 3125388
SGTC_752 1896-0090 130 µM -0.989526156570072 0.225543977436884 no 2629 0.161202889434686 4049 772567
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.989910438815323 0.225455836045894 no 2630 0.161108948370532 4110 5282362
SGTC_142 0335-0849 62.6745 µM -0.990124954210281 0.225406641928314 no 2631 0.161056523796357 4080 3889043 YPR107C YTH1
SGTC_2331 7980721 200 µM -0.992531840881696 0.224855095232047 no 2632 0.160469077506398 4055 2981221
SGTC_2321 7390090 138.78 µM -0.993775021696624 0.224570515821155 no 2633 0.160166204637048 4122 649046
SGTC_792 4534-1957 155 µM -0.994033627727481 0.224511343397555 no 2634 0.160103248115708 4020 1717904
SGTC_356 1634-0012 32.5 µM -0.995509148039262 0.224173894447692 no 2635 0.159744348628597 4105 735457
SGTC_2785 7756463 72.73 µM -0.996978264719738 0.22383819634386 no 2636 0.159387530108166 4043 2201551
SGTC_2149 5554786 194.827 µM -0.999130510533055 0.223346917212093 no 2637 0.158865736394102 4110 745063 YPR165W RHO1
SGTC_2377 9073351 62.6 µM -0.99913872464162 0.223345043407151 no 2638 0.15886374710029 4058 7337946 YHR072W ERG7
SGTC_393 acivicin 6.25 µM -0.999965944821633 0.223156383508696 no 2639 0.158663494427954 3941 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2580 diallyl disulphide 81.36 µM -1.00088073099244 0.222947858562229 no 2640 0.15844223666188 4084 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_440 fluspirilene 35.1 µM -1.00089781751918 0.222943964755149 no 2641 0.158438105899274 4184 3396 An atypical antipsychotic.
SGTC_3122 9126309 49.47 µM -1.0014362127142 0.222821291024402 no 2642 0.158307982057702 4130 17591206
SGTC_2228 7354201 200 µM -1.00159715069705 0.222784628657934 no 2643 0.158269098840386 4120 753451
SGTC_851 0394-0702 453 µM -1.00286412848071 0.222496125733337 no 2644 0.157963211157496 4104 762646
SGTC_1763 st044482 94.5 µM -1.00397493709724 0.222243359388004 no 2645 0.157695347100927 4091 88505
SGTC_831 k061-1017 217 µM -1.00448263067668 0.222127887450876 no 2646 0.157573019607916 4127 1240153
SGTC_1731 st035964 63 µM -1.00649201766861 0.221671200246259 no 2647 0.157089474761398 4039 6739575
SGTC_2730 imipramine 71.33 µM -1.00701056389413 0.221553433828952 no 2648 0.156964848847391 4066 3696 A tricyclic antidepressant.
SGTC_2739 tacrine 100.86 µM -1.00831547018039 0.221257236389698 no 2649 0.156651519271146 4142 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2352 9027995 87.8 µM -1.01172777888146 0.220483756396816 no 2650 0.155834114821164 4055 2997347
SGTC_1399 3562-5772 25 µM -1.01294346150305 0.220208568162476 no 2651 0.155543583673665 4054 23847490
SGTC_2854 9024559 71.43 µM -1.01424164200864 0.21991492286122 no 2652 0.155233731448682 4157 3163529
SGTC_2751 anetholtrithion 17.25 µM -1.01435998075901 0.219888166101328 no 2653 0.155205506404472 4118 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_25 0118-0223 35.662 µM -1.01481345520572 0.219785651415865 no 2654 0.15509737931561 4081 5333628
SGTC_2413 inermin 26.06 µM -1.01490908774063 0.219764035753651 no 2655 0.155074582910519 4207 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3031 9088762 49.47 µM -1.0153235385598 0.219670372233296 no 2656 0.154975813769415 4080 205253
SGTC_247 mechlorethamine 29.705 µM -1.01537666922389 0.219658366664183 no 2657 0.154963155030628 4002 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1211 1056-0033 32.3 µM -1.01585601426344 0.219550069411946 no 2658 0.154848978717334 4166 6741922
SGTC_1447 4239-0816 81.9 µM -1.01617173149119 0.219478756945685 no 2659 0.154773807655859 4118 1341554
SGTC_1421 4029-0249 71.4 µM -1.01704367938235 0.21928187530287 no 2660 0.154566325462935 4170 2894095
SGTC_2793 7325131 81.82 µM -1.01747092719331 0.219185441867081 no 2661 0.154464727909456 4083 4176441
SGTC_1361 1608-0041 5.61 µM -1.01964435765375 0.218695257894754 no 2662 0.153948579832921 4082 X1361
SGTC_2706 st078239 82.5 µM -1.02092099670529 0.218407625898762 no 2663 0.153645935208182 4085 15434492
SGTC_3288 9119690 36.221 µM -1.02562274448523 0.217350183717842 no 2664 0.152534721157199 4123 17595618 YKL019W RAM2
SGTC_2295 7971645 200 µM -1.02621550716942 0.217217079153352 no 2665 0.152395006725648 4173 2978226 YKL099C UTP11
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.02853761133222 0.216696105545196 no 2666 0.151848504050668 4138 115019
SGTC_2945 9067681 61.76 µM -1.03109015530751 0.216124266467644 no 2667 0.151249271985363 4190 16456930
SGTC_507 nimesulide 162 µM -1.03367677201869 0.215545686689837 no 2668 0.150643647768975 4189 4495 A COX2 inhibitor.
SGTC_1987 st072290 61.9 µM -1.0351062176931 0.215226331080148 no 2669 0.150309654580739 4139 54697379
SGTC_3004 9076122 71.4286 µM -1.03513063128021 0.215220879173067 no 2670 0.1503039545805 4158 44782551
SGTC_1814 st052110 31.539 µM -1.03609175855465 0.215006309253246 no 2671 0.150079668353372 4082 674163
SGTC_3018 9082602 49.47 µM -1.036313702151 0.214956778408758 no 2672 0.150027907885114 4083 17332089
SGTC_145 3737-0113 38.366 µM -1.0374456493266 0.214704266434179 no 2673 0.149764106541695 4088 6849351
SGTC_3056 9094900 49.47 µM -1.03828691584494 0.214516710492858 no 2674 0.149568249155087 4107 25236784
SGTC_610 4215-0184 155 µM -1.04076914127059 0.213963866871226 no 2675 0.148991352575524 4144 5605015
SGTC_1406 3909-7906 11.9 µM -1.04132844080175 0.213839413738633 no 2676 0.148861570676881 4149 X1406
SGTC_2658 polymyxin b sulfate 77.05 µM -1.04143284625724 0.213816186516872 no 2677 0.148837352424629 4160 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.04182838991428 0.213728202716786 no 2678 0.148745624627854 4217 688664
SGTC_1333 1482-0047 286 µM -1.04253708669705 0.213570614623499 no 2679 0.148581370168832 4156 3811116
SGTC_620 0109-0052 432 µM -1.04255928503519 0.213565679623526 no 2680 0.148576227225573 4135 493037
SGTC_292 k038-0015 474 µM -1.0436086421116 0.213332468741079 no 2681 0.148333246446746 4142 46368540
SGTC_2034 5197015 53.07 µM -1.04368067416184 0.213316465664522 no 2682 0.148316577032752 4143 780676
SGTC_3105 9121040 49.47 µM -1.04490382498699 0.213044829936585 no 2683 0.148033710895305 4006 41448907
SGTC_175 3793-3120 23.7 µM -1.04646481277413 0.212698461092346 no 2684 0.14767324125933 4151 5322297
SGTC_2560 caryophyllene 100 µM -1.04653897416136 0.212682013547874 no 2685 0.147656130251531 4181 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1835 st008666 49.2 µM -1.04816863934601 0.212320773205603 no 2686 0.147280458281015 4084 690455
SGTC_1850 st056238 17 µM -1.05074889391345 0.21174955402228 no 2687 0.146686966725251 4157 5393177
SGTC_998 3996-0085 177 µM -1.05143770183813 0.21159721729625 no 2688 0.146528803848661 4173 715391
SGTC_1206 3978-0017 132 µM -1.05459672428799 0.21089939036506 no 2689 0.145804901291362 4239 3873677
SGTC_870 0573-2213 57.6 µM -1.05575926069723 0.210642926553098 no 2690 0.14553910754138 4144 3916321
SGTC_890 0929-0006 47.2 µM -1.05648338418619 0.21048327228092 no 2691 0.14537371407363 4118 1378169
SGTC_2687 chenodiol 100 µM -1.05716813344998 0.210332364568834 no 2692 0.145217430230717 4242 5702181 A cholesterol synthesis inhibitor.
SGTC_3319 9138450 16.7555 µM -1.05822183694088 0.210100269418918 no 2693 0.144977158978419 4082 2029690
SGTC_263 alizarin 107.927 µM -1.06049163445952 0.209600821414834 no 2694 0.144460496893165 4176 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_833 3852-0053 558 µM -1.06061748618702 0.209573149351016 no 2695 0.144431886274603 4225 3123681
SGTC_1939 st074455 53.6 µM -1.06078937944151 0.20953535722662 no 2696 0.144392814932821 4172 1644229
SGTC_3248 9135562 49.47 µM -1.06231803572887 0.209199446148362 no 2697 0.144045664667648 4130 17650701
SGTC_224 benfluorex 43.875 µM -1.06534221185263 0.208535840211722 no 2698 0.143360548625548 4184 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3164 9100705 49.47 µM -1.06688750631006 0.208197230331196 no 2699 0.143011318604041 4192 17174235
SGTC_2361 9034121 116 µM -1.06731277311015 0.208104101464584 no 2700 0.142915311052464 4158 6496917
SGTC_1325 1431-0015 227 µM -1.0687644515825 0.207786384719024 no 2701 0.142587910624037 4161 1103340
SGTC_2340 7987427 183.45 µM -1.07082088298305 0.207336801476194 no 2702 0.142124987618048 4194 2239331
SGTC_958 1222-0007 33 µM -1.07114732803802 0.207265486006946 no 2703 0.142051595272951 4251 7312461
SGTC_770 0389-1121 67.2 µM -1.07364372099995 0.206720601625166 no 2704 0.141491197086092 4260 6753108
SGTC_2823 7987624 58.44 µM -1.07975087563233 0.205391181748563 no 2705 0.140126565962959 4178 2239440
SGTC_1348 1493-0373 93.8 µM -1.08001766569182 0.205333222246175 no 2706 0.140067156798199 4177 3010129
SGTC_1260 0700-1617 7.75 µM -1.08446089331699 0.204369370670043 no 2707 0.139080248611469 4165 2853078
SGTC_2981 9013952 38.96 µM -1.08490306120933 0.204273600536954 no 2708 0.138982296017246 4150 2996344
SGTC_733 4069-0007 56.1 µM -1.08644297195275 0.20394027647564 no 2709 0.138641529252165 4181 5717425 YNL287W SEC21
SGTC_2463 5473429 200 µM -1.08674062418069 0.203875885042817 no 2710 0.138575727505418 4155 5399405
SGTC_1229 0139-0193 12.2 µM -1.08701872150911 0.20381573489304 no 2711 0.138514267975357 4259 3090752
SGTC_2836 9010338 19.48 µM -1.09027912233239 0.203111326487421 no 2712 0.137795104476148 4162 2994051
SGTC_2826 7992541 19.48 µM -1.09127550704068 0.202896348237134 no 2713 0.13757583590388 4194 2985066
SGTC_1375 2910-0797 186 µM -1.09131973217812 0.202886809448773 no 2714 0.137566109059089 4194 742508
SGTC_3356 9151811 4.48 µM -1.09412148953617 0.202283052920645 no 2715 0.136950849337167 4189 1859254 YPR165W RHO1
SGTC_695 3505-6186 243 µM -1.09416213516501 0.202274302025206 no 2716 0.136941937507121 4195 1819379
SGTC_2775 cyproheptadine 69.59 µM -1.09520887541788 0.202049019655972 no 2717 0.136712569119369 4187 2913 A selective serotonin reuptake inhibitor.
SGTC_3127 9126946 49.47 µM -1.0959168278647 0.201896737306052 no 2718 0.13655758705198 4184 27243249
SGTC_2400 5203494 178.7 µM -1.09873447742652 0.201291335089615 no 2719 0.135941949704828 4098 6777674
SGTC_1614 st002383 48.6 µM -1.10144462579715 0.200710058673956 no 2720 0.135351596103286 4218 1947235
SGTC_885 0865-0106 16.8 µM -1.10194528610804 0.200602786719554 no 2721 0.135242729486901 4122 2793380
SGTC_466 geldanamycin 89.2 µM -1.10669632890006 0.199586538088808 no 2722 0.134212621560742 4138 5288382 HSP90 inhibitor.
SGTC_1051 3253-3903 78 µM -1.10790392380317 0.199328728065088 no 2723 0.133951655419263 4181 5509239
SGTC_2031 5180455 200 µM -1.1099603466986 0.198890163102786 no 2724 0.1335080570582 4166 29949
SGTC_645 0845-0943 5.41 µM -1.11174974035118 0.198509020011265 no 2725 0.133122883461176 4206 1885106
SGTC_1482 3346-2049 8.48 µM -1.11223991378979 0.198404689386159 no 2726 0.133017505395778 4211 3826804
SGTC_2761 levamisole 97.89 µM -1.11396064552367 0.198038703455666 no 2727 0.132648035122475 4224 26879 An alkaline phosphatase inhibitor.
SGTC_1667 st014849 34.6 µM -1.11777703891297 0.197228443146991 no 2728 0.131831115183821 4269 5348460
SGTC_594 1487-1584 10.8 µM -1.11941993330607 0.196880257860862 no 2729 0.131480515508091 4167 5013332
SGTC_122 0236-0016 402.397 µM -1.11974117722167 0.196812218857664 no 2730 0.131412036184501 4202 6808838
SGTC_3341 9147222 25.867 µM -1.12010897986812 0.196734336267362 no 2731 0.131333662212305 4217 1939759
SGTC_2293 7624732 200 µM -1.12240001031539 0.196249628587567 no 2732 0.13084620004886 4105 894453
SGTC_3293 9120939 62.045 µM -1.12251669328678 0.196224961650636 no 2733 0.130821406941092 4211 934087
SGTC_3067 9117431 49.47 µM -1.12355324805265 0.196005915118065 no 2734 0.130601299570905 4244 17150885
SGTC_359 0081-0058 15.9 µM -1.12386573968878 0.195939907960073 no 2735 0.130534993752042 4320 3494159
SGTC_864 0469-0573 172 µM -1.12415003660522 0.195879868049752 no 2736 0.130474690636254 4202 689425
SGTC_2850 9015429 58.44 µM -1.12439979003335 0.195827132499303 no 2737 0.130421730548385 4236 6457570
SGTC_1702 st027038 51 µM -1.12501257850624 0.19569777844295 no 2738 0.130291852063953 4245 5521182
SGTC_983 1491-0821 12.2 µM -1.12605914672661 0.19547697741383 no 2739 0.130070242365658 4210 46495113
SGTC_1937 st074714 47.2 µM -1.1263854697954 0.195408161954644 no 2740 0.130001197189078 4167 17250970
SGTC_94 0334-0113 514.748 µM -1.12787542906566 0.195094144314445 no 2741 0.129686266043344 4234 6795178
SGTC_1041 0206-0046 107 µM -1.12975802461398 0.194697815202603 no 2742 0.12928909992775 4219 50494
SGTC_2221 6807166 181.081 µM -1.13036341518126 0.194570470898495 no 2743 0.12916156163291 4185 674925
SGTC_2062 5245942 200 µM -1.13163928542129 0.194302256784013 no 2744 0.128893058327505 4262 1376160
SGTC_2370 9071495 200 µM -1.13172764094467 0.194283690978346 no 2745 0.128874478499984 4230 21791103
SGTC_390 dec-rvkr-cmk 16.7 µM -1.13263074090147 0.194093988019795 no 2746 0.128684676797196 4274 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1965 Pectolinarigenin 58.4 µM -1.13294526011859 0.194027947387232 no 2747 0.128618620833408 4192 5320438 An anti-inflammatory.
SGTC_1382 3002-2117 298 µM -1.13331366277553 0.193950610084334 no 2748 0.128541278086979 4295 1497314
SGTC_872 0588-0139 234 µM -1.13404032688094 0.193798119460994 no 2749 0.12838881629028 4187 2047100
SGTC_3045 9092950 49.47 µM -1.13526332272884 0.193541638582512 no 2750 0.128132502395819 4169 44120432
SGTC_2804 7954240 19.48 µM -1.13576905253384 0.193435639866214 no 2751 0.128026616134867 4256 828705
SGTC_1104 tacrolimus 29.8 µM -1.1366173952821 0.193257910555889 no 2752 0.127849132449211 4279 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1297 1068-0111 14.1 µM -1.13695224615858 0.193187786145049 no 2753 0.127779124633297 4203 767057
SGTC_2176 5809774 33.9695 µM -1.14399404564941 0.191716693778616 no 2754 0.126313053188533 4165 2870539
SGTC_2717 st081029 62.2815 µM -1.14449063924154 0.191613210704213 no 2755 0.126210108877714 4209 5292846
SGTC_1276 0871-0068 94.2 µM -1.14450279004697 0.191610679077267 no 2756 0.126207590737648 4234 3414906
SGTC_125 0133-0007 11.75 µM -1.14597848053162 0.191303370512796 no 2757 0.12590202812068 4325 26541
SGTC_693 4161-2696 114 µM -1.14996948157247 0.190473769816842 no 2758 0.125078220598531 4281 805759
SGTC_2253 7938677 135.83 µM -1.15075055155001 0.190311669351499 no 2759 0.124917436552289 4294 2301972
SGTC_2570 licareol 100 µM -1.15163820465725 0.190127551912321 no 2760 0.124734887621488 4227 443158
SGTC_2729 fluphenazine 10.66 µM -1.15568775315895 0.189288982131907 no 2761 0.123904449655663 4170 3372 An atypical antipsychotic.
SGTC_2783 7738165 71.43 µM -1.1559590572511 0.189232882699049 no 2762 0.123848952159871 4240 17201110
SGTC_2683 piperine 63.03 µM -1.15696713366695 0.189024525428553 no 2763 0.123642894240629 4225 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2365 9042475 200 µM -1.15816466614329 0.188777193594222 no 2764 0.123398422302506 4305 6464479
SGTC_253 dyclonine 31.25 µM -1.15935183567463 0.188532199033433 no 2765 0.123156400369894 4349 3180 An oral anasthetic.
SGTC_1236 0330-0013 258 µM -1.16172921492333 0.1880421722814 no 2766 0.122672737363228 4264 4617066
SGTC_2318 6029776 164 µM -1.16687389702073 0.186984442202115 no 2767 0.121630649375396 4310 818325
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.16767803116383 0.186819448080011 no 2768 0.121468330788746 4317 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_510 ag-490 170 µM -1.16904408276175 0.186539365050978 no 2769 0.121192935486591 4388 5328779
SGTC_443 clozapine 122 µM -1.16976613873204 0.186391426244073 no 2770 0.121047546913096 4213 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1164 k060-0068 93.7 µM -1.17070375856238 0.186199430025419 no 2771 0.120858936962049 4258 5963676
SGTC_3238 9133470 49.47 µM -1.17123965359191 0.186089749975367 no 2772 0.120751230196088 4260 3534688
SGTC_3177 9107506 49.47 µM -1.17164067934836 0.186007699423804 no 2773 0.120670674317039 4209 8897194
SGTC_2185 6113692 200 µM -1.17271954613903 0.185787072804879 no 2774 0.120454145232535 4263 874150
SGTC_1096 rimcazole 32.2 µM -1.17427645979139 0.185468972604307 no 2775 0.120142154514963 4189 18528119 A dopamine reuptake inhibitor.
SGTC_1750 st081859 2.357 µM -1.1775287422338 0.184805575276235 no 2776 0.119492266222253 4220 5291695
SGTC_1963 st076565 50.3 µM -1.17795632258009 0.184718467696596 no 2777 0.11940700967203 4286 4914280
SGTC_1370 2001-0092 44.6 µM -1.18015368803025 0.18427121848328 no 2778 0.118969547345363 4302 790957
SGTC_2998 9066762 71.4286 µM -1.1804946947113 0.184201870831507 no 2779 0.118901759633338 4328 4945196
SGTC_2203 7227154 166.4 µM -1.18100308626349 0.18409851369377 no 2780 0.118800748633263 4280 896304
SGTC_654 1124-0271 80.9 µM -1.18259528323043 0.183775050142789 no 2781 0.118484791378764 4243 5403748
SGTC_876 0720-0963 56.8 µM -1.18373005608053 0.183544731027257 no 2782 0.118259968628614 4294 765861
SGTC_1829 berberine 14.4 µM -1.18669285620313 0.182944234958507 no 2783 0.117674396946482 4240 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_26 0302-0163 425.158 µM -1.19017421132328 0.182240207513431 no 2784 0.116988963475647 4336 3100915
SGTC_326 k292-0812 17.5 µM -1.19099239582404 0.182074993762539 no 2785 0.116828285045514 4265 3579357
SGTC_2999 9069765 71.4286 µM -1.19100121222903 0.182073214000169 no 2786 0.116826554496059 4235 2097066
SGTC_2362 9071156 126 µM -1.19261512985124 0.181747596666906 no 2787 0.116510068826677 4283 653133
SGTC_1379 2144-0755 36.5 µM -1.19290788383446 0.181688570895455 no 2788 0.11645272563789 4330 5392327
SGTC_340 k038-0059 454 µM -1.19301166832359 0.181667648493961 no 2789 0.116432401657628 4239 23733424
SGTC_1366 1683-0113 21.9 µM -1.19322615552183 0.181624413792099 no 2790 0.116390406884831 4274 708623
SGTC_1270 0831-1170 17.3 µM -1.19807251344406 0.180649238651102 no 2791 0.115444394198339 4294 6764716
SGTC_1405 3909-7894 12 µM -1.19948746398783 0.180365145298755 no 2792 0.115169228176674 4265 7104060
SGTC_442 cape 100 µM -1.20224169838617 0.179812955338714 no 2793 0.114634948990452 4292 5281787
SGTC_344 k064-0035 6.43 µM -1.20225595668085 0.17981009949262 no 2794 0.114632187697129 4228 5088750
SGTC_3040 9091894 49.47 µM -1.20458414085857 0.179344161153335 no 2795 0.114181941030344 4137 25236966
SGTC_1721 st082152 9.2685 µM -1.2049843022679 0.179264153573191 no 2796 0.114104680984656 4213 5296051
SGTC_1766 st045414 44.774 µM -1.20762646808996 0.178736447050624 no 2797 0.113595486769998 4295 253960
SGTC_1438 4092-1045 4 µM -1.2078629167131 0.178689270078095 no 2798 0.113549997849403 4306 1351342
SGTC_2521 angolensin 13.4 µM -1.20876210140244 0.178509933533262 no 2799 0.113377127761654 4342 821428 A flavenoid.
SGTC_542 3381-0244 89.3 µM -1.21093402371747 0.178077225570489 no 2800 0.112960345761142 4310 1112843
SGTC_1420 4'-methoxyflavone 42 µM -1.21131038831881 0.178002310442616 no 2801 0.112888234420055 4278 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_376 3970-0862 59.1 µM -1.2129650246112 0.177673191947259 no 2802 0.112571596437201 4330 3135186
SGTC_1561 5-methoxyflavone 52.9 µM -1.21407099894352 0.177453420311756 no 2803 0.112360306672757 4256 94525
SGTC_360 0957-0399 1.01 µM -1.21415187930726 0.177437355056976 no 2804 0.112344866090642 4310 6752301 YPR165W RHO1
SGTC_1122 capsaicin 818.572 nM -1.21563069053273 0.177143780879364 no 2805 0.11206281875576 4351 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1166 k206-0078 225 µM -1.21655548144728 0.176960347051267 no 2806 0.111886694814201 4317 5404595
SGTC_2757 clomiphene 4.22 µM -1.21684808212095 0.176902334222509 no 2807 0.111831011048406 4320 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_951 1171-0579 82.7 µM -1.21724982595078 0.176822701576002 no 2808 0.111754588939489 4254 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_235 0330-0087 5 mM -1.21744514979674 0.176783993164392 no 2809 0.111717446770893 4351 46494818 YHR062C RPP1
SGTC_2404 5161160 200 µM -1.21899328409874 0.17647738029647 no 2810 0.111423370754332 4248 2831543
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.22156470992438 0.175968845199122 no 2811 0.110936140405753 4278 2724278 An inhibitor of dopamine biosynthesis.
SGTC_561 1550-0330 72.9 µM -1.22361796218304 0.175563453064492 no 2812 0.110548190179376 4250 6812934
SGTC_745 0469-0705 296 µM -1.22559687045185 0.1751732999205 no 2813 0.110175208060989 4355 3486736
SGTC_2654 protoveratrine a 100 µM -1.22786138695024 0.174727512724968 no 2814 0.109749503347243 4316 5702278 A heart drug and vasodilator.
SGTC_2157 5649910 96.377 µM -1.22987841902044 0.174331051700743 no 2815 0.109371318393406 4293 2858091
SGTC_1133 3473-0247 50 µM -1.23267187314647 0.173782924490602 no 2816 0.108849104877278 4290 711311
SGTC_1398 3558-0053 112 µM -1.23351454742034 0.17361779171097 no 2817 0.108691926307888 4255 4532369
SGTC_1121 fusaric acid 630.51 nM -1.23431588790597 0.17346085146252 no 2818 0.108542608939334 4280 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_938 3126-1755 342 µM -1.2348513902139 0.173356025211098 no 2819 0.108442908678626 4307 1777771
SGTC_1767 st044992 70.3 µM -1.23600220296069 0.173130886512763 no 2820 0.108228872401691 4361 9600693
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.23647987434726 0.173037492217116 no 2821 0.108140121060586 4315 7104
SGTC_2680 butyl paraben 22.24 µM -1.23915812267279 0.172514435800021 no 2822 0.107643472855182 4418 7184 An antifungal and steroid mimetic.
SGTC_2226 7298446 200 µM -1.24224070187549 0.171913663901304 no 2823 0.107073883259719 4321 3283010
SGTC_216 k038-0035 28.382 µM -1.24289297802824 0.171786711546737 no 2824 0.106953636817745 4241 4444231 YPR107C YTH1
SGTC_817 1391-0715 46 µM -1.24341060329374 0.171686008885153 no 2825 0.106858282478429 4305 1353946
SGTC_2540 epiandrosterone 100 µM -1.24569224107149 0.171242571712304 no 2826 0.106438701621922 4357 441302 A steroid.
SGTC_184 1494-0393 24.714 µM -1.24643421791068 0.171098526163274 no 2827 0.106302512745131 4287 3090647
SGTC_3304 9125678 46.087 µM -1.24668463666126 0.171049927982447 no 2828 0.106256577128193 4257 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1251 0490-5699 265 µM -1.24786512592572 0.170820952123914 no 2829 0.106040226916158 4362 3883818
SGTC_1352 1496-0991 99 µM -1.24793792764007 0.170806837424456 no 2830 0.106026894853499 4321 3000039
SGTC_474 dl-dihydrosphingosine 5 µM -1.25298599090814 0.169829946060634 no 2831 0.105105402529739 4341 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1440 4100-1550 40 µM -1.25613685288181 0.169222016999632 no 2832 0.104533178336749 4323 742806
SGTC_3149 9097855 49.47 µM -1.25626421673083 0.169197472762246 no 2833 0.104510095495958 4324 25236625 YMR079W SEC14
SGTC_496 calpeptin 138 µM -1.26139861999301 0.16820992753304 no 2834 0.103582632641314 4332 73364 A calpain inhibitor.
SGTC_2734 clemastine 41.6 µM -1.26231818852466 0.168033451094519 no 2835 0.103417157208075 4403 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.26243509179689 0.16801102446788 no 2836 0.103396134337164 4370 23847180
SGTC_2148 5546263 113.568 µM -1.26521896248728 0.167477538224573 no 2837 0.102896423375124 4340 792097
SGTC_1633 st005664 67.9 µM -1.26597436703374 0.167332964958069 no 2838 0.102761129745458 4331 2063822
SGTC_537 1334-0398 209 µM -1.26719706684216 0.16709912878959 no 2839 0.102542417161526 4367 5846986
SGTC_1057 3448-5381 134 µM -1.26846498809001 0.166856866847345 no 2840 0.102315973138352 4322 5497911
SGTC_997 3996-0078 137 µM -1.27065457192209 0.166439036438113 no 2841 0.101925781755025 4384 735687
SGTC_2571 chrysanthemic acid 100 µM -1.27128363863058 0.166319118925344 no 2842 0.101813880419574 4322 2743 An insecticide.
SGTC_3102 9121669 49.47 µM -1.27148544049859 0.166280661731353 no 2843 0.101778001909583 4386 41905072
SGTC_1071 trifluoperazine 6.31 µM -1.27195017888053 0.1661921188145 no 2844 0.101695410720399 4401 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2154 5570129 200 µM -1.27343417788127 0.165909588193434 no 2845 0.101432007877172 4386 673366
SGTC_363 0455-0021 3.06 µM -1.2738678778283 0.165827077036616 no 2846 0.101355122098243 4298 4597466
SGTC_1310 1188-0297 994 nM -1.27590502713798 0.165439865582871 no 2847 0.100994546891112 4224 1588352
SGTC_1472 k841-0093 193 µM -1.27599933766939 0.165421953672325 no 2848 0.100977876613595 4463 X1472
SGTC_3332 9141069 11.198 µM -1.28269437674676 0.164153605843721 no 2849 0.0997995853805402 4299 17332883
SGTC_418 lividomycin a 100 µM -1.28311041436835 0.164074997915347 no 2850 0.0997266978273804 4353 72394 An antibiotic.
SGTC_738 1315-0003 72.4 µM -1.28754086727341 0.163239404110536 no 2851 0.0989529174429054 4379 6251474
SGTC_2231 micatex 6.853 µM -1.28764095723628 0.163220558903644 no 2852 0.0989354875677184 4369 20737 An antifungal of unknown mechanism.
SGTC_2368 9071271 200 µM -1.28849949551539 0.163058969084394 no 2853 0.0987860721745408 4341 27209959
SGTC_2263 7948595 193.29 µM -1.28977669331647 0.162818773721003 no 2854 0.0985641011756496 4366 2971371
SGTC_777 1315-0167 517 µM -1.29470320075092 0.161894430032086 no 2855 0.0977113176897105 4383 4221767
SGTC_1089 terbinafine 2.25 µM -1.29934328068284 0.161026960422142 no 2856 0.096913073696072 4377 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2634 4'-methoxyflavone 100 µM -1.30059737198492 0.160793027942451 no 2857 0.0966981535351627 4370 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_593 1203-0218 61.7 µM -1.3014201865294 0.160639664478159 no 2858 0.0965573338280928 4397 3666956
SGTC_3196 9111891 49.47 µM -1.30682253710314 0.159635100201257 no 2859 0.095636494575746 4352 18891510
SGTC_3158 9100007 49.47 µM -1.30733173371487 0.159540627820238 no 2860 0.0955500355709976 4384 19297233
SGTC_1534 6-azauridine 81.6 µM -1.30744297782224 0.15951999332505 no 2861 0.0955311545437167 4402 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2447 5741742 33.78 µM -1.30938386097077 0.159160263082744 no 2862 0.0952021777803553 4426 1776504
SGTC_1513 0337-0559 19 µM -1.31487029224473 0.158146264519874 no 2863 0.0942767492361095 4360 775073
SGTC_1774 st048371 48.465 µM -1.31897638601047 0.157390159177777 no 2864 0.0935885035503007 4356 4242727
SGTC_2512 diallyl trisulfide 49.23 µM -1.31965724538879 0.157265014248675 no 2865 0.0934747403789865 4422 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2151 5563267 85.4165 µM -1.32064206292355 0.157084116264567 no 2866 0.0933103703234242 4440 5310824
SGTC_1564 D-Arginine 115 µM -1.32308185949923 0.15663654756583 no 2867 0.0929040783391992 4386 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.32632526473882 0.156042861791982 no 2868 0.0923659908906862 4385 688751
SGTC_756 0508-1999 28.3 µM -1.3298796144182 0.15539396474905 no 2869 0.0917789695245004 4401 6753853
SGTC_1497 4476-2978 41.3 µM -1.33268924434464 0.154882288739575 no 2870 0.0913169021744683 4432 1528379
SGTC_2728 chlorpromazine 9.18 µM -1.33348952721019 0.154736749021768 no 2871 0.0911856050238964 4466 2726 A thorazine and dopamine antagonist.
SGTC_1231 0242-0792 125 µM -1.33368449934833 0.154701305014714 no 2872 0.0911536384441526 4392 3707635
SGTC_1761 st044296 37 µM -1.33530797101921 0.154406382236988 no 2873 0.0908877854257499 4392 1826700
SGTC_288 1315-0019 35.1 µM -1.34005188929399 0.153546724910331 no 2874 0.0901142378906441 4424 6811474
SGTC_2756 carbadox 75.1 µM -1.34243827584266 0.153115482351885 no 2875 0.0897269655891105 4333 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_575 k072-0246 11.9 µM -1.34335343560528 0.152950317508593 no 2876 0.0895787785121356 4478 6796779
SGTC_1065 prochlorperazine maleate 2.48 µM -1.34667192632345 0.152352398952812 no 2877 0.0890429588583477 4438 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1329 1447-1697 50.6 µM -1.3472174225116 0.152254261297525 no 2878 0.0889551091656704 4402 2840515
SGTC_1759 st043059 70 µM -1.3492648046597 0.151886300830894 no 2879 0.0886259630362311 4406 669426
SGTC_2028 5153890 36.43 µM -1.35614283294684 0.1506544943438 no 2880 0.0875268634172258 4391 2830968 YPR165W RHO1
SGTC_886 0866-0150 153 µM -1.35637685663686 0.150612699708788 no 2881 0.0874896464995154 4449 271463
SGTC_2297 7971671 152.32 µM -1.36041957382326 0.14989192382734 no 2882 0.0868485939060822 4401 909016
SGTC_2865 9030313 51.95 µM -1.36287132282807 0.149455924025964 no 2883 0.086461534012204 4396 42562754
SGTC_2705 st078069 42.8 µM -1.3650586024456 0.149067670539208 no 2884 0.0861173159716024 4438 1530061
SGTC_863 0466-0191 129 µM -1.36560298021594 0.148971145456488 no 2885 0.0860318053301856 4460 765160 YPR165W RHO1
SGTC_2960 9079389 5.97 µM -1.36615187360603 0.148873861984568 no 2886 0.085945649715142 4394 16457355
SGTC_1437 4092-1038 11.6 µM -1.37007096158696 0.148180493718929 no 2887 0.0853323756974431 4480 3977136
SGTC_485 niflumic acid 177 µM -1.37013821568156 0.148168613957936 no 2888 0.0853218802028578 4448 4488 A COX2 inhibitor.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.37050389539562 0.148104031458578 no 2889 0.0852648301258503 4418 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1435 4092-0789 56.7 µM -1.37184307859823 0.147867679861713 no 2890 0.0850561467148455 4403 2248285
SGTC_40 0327-0103 19.753 µM -1.37419555992537 0.147453103647765 no 2891 0.084690489406294 4256 409036
SGTC_3210 9128157 49.47 µM -1.37658881007804 0.147032142678813 no 2892 0.0843197062282747 4385 17590849
SGTC_547 1120-0019 610 nM -1.37971275689012 0.146483869385654 no 2893 0.0838375517646343 4379 3676939
SGTC_1344 1488-0097 29.1 µM -1.38366169855047 0.145792770305715 no 2894 0.0832310333150127 4454 747966
SGTC_333 3486-0131 40.1 µM -1.38399985125135 0.145733692683071 no 2895 0.083179250142807 4446 6744690
SGTC_192 3455-0609 60.9 µM -1.38413774801362 0.145709605782004 no 2896 0.0831581402126739 4483 3769639
SGTC_1365 1672-3266 55.4 µM -1.38549280475916 0.145473055733293 no 2897 0.0829509155621091 4442 6415873
SGTC_3153 9100258 49.47 µM -1.38566387392179 0.145443210839863 no 2898 0.0829247821217194 4348 25236848
SGTC_384 k007-0144 5.16 µM -1.38662723226878 0.145275219299288 no 2899 0.0827777299824092 4360 6824886
SGTC_2172 5754775 163.918 µM -1.38772804241914 0.145083418631454 no 2900 0.0826099367767139 4418 2263357
SGTC_3263 9137018 49.47 µM -1.39079818689403 0.144549390051089 no 2901 0.0821433165392251 4385 43844957
SGTC_3170 9103054 49.47 µM -1.3915114045713 0.14442552099382 no 2902 0.0820352018797994 4405 16432970
SGTC_2873 9040596 71.43 µM -1.39426318611675 0.14394827211954 no 2903 0.0816190717304808 4399 6463863
SGTC_2935 9038016 29.96 µM -1.39677091099122 0.143514278041688 no 2904 0.0812412362004417 4384 6463195
SGTC_2290 7904846 200 µM -1.39817895827791 0.143270984927922 no 2905 0.0810296669078238 4469 2962154
SGTC_2330 7979373 200 µM -1.39940386132224 0.143059563552266 no 2906 0.0808459548194749 4359 1863007
SGTC_1921 5740136 50 µM -1.40235927638816 0.142550319616321 no 2907 0.0804039938321067 4384 1774243
SGTC_2056 5235370 200 µM -1.41110405853641 0.141050703946366 no 2908 0.0791069667440387 4360 5511916
SGTC_3278 9139605 49.47 µM -1.41248629511445 0.140814651272098 no 2909 0.0789034116073499 4429 7958859
SGTC_2455 5377712 9.75 µM -1.41859895750607 0.139773970624807 no 2910 0.0780079849949371 4439 2243908
SGTC_2716 st080858 38.6235 µM -1.41998819021721 0.139538184818755 no 2911 0.0778055596217184 4423 5296050
SGTC_2382 9035899 200 µM -1.42329741120936 0.138977621521312 no 2912 0.0773249785695514 4450 6462679
SGTC_2605 digitonin 300 nM -1.42393327713674 0.13887008527973 no 2913 0.0772328938613157 4451 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2384 9036245 200 µM -1.42417096430672 0.138829902702624 no 2914 0.0771984939273361 4387 6462766
SGTC_2784 7567673 72.73 µM -1.4252679632698 0.13864455043209 no 2915 0.0770398785504755 4370 3471247
SGTC_727 3032-0951 202 µM -1.42549384197476 0.138606406220773 no 2916 0.0770072494591719 4496 3652836
SGTC_1237 0330-0133 46.1 µM -1.42738454367094 0.138287403196841 no 2917 0.0767345417545734 4384 X1237 YHR072W ERG7
SGTC_1932 st074806 40.9 µM -1.43032924178179 0.137791565208636 no 2918 0.0763112729644116 4492 17251235
SGTC_2678 equilin 100 µM -1.43288323418133 0.137362498996278 no 2919 0.0759456046775465 4451 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_979 1426-2828 121 µM -1.43733274842367 0.136617169746663 no 2920 0.07531173392225 4531 747872
SGTC_2958 9077254 16.72 µM -1.43768421925329 0.136558413644587 no 2921 0.0752618363239544 4487 16457351
SGTC_614 0462-0418 107 µM -1.44236158095252 0.135778134645673 no 2922 0.0746001980718703 4235 5188303
SGTC_1306 1185-0270 9.02 µM -1.44341798157649 0.13560232908496 no 2923 0.0744513808539191 4481 1548076
SGTC_3311 9131146 2.8755 µM -1.44467301800151 0.13539366944708 no 2924 0.0742748761176577 4397 4900406 YPR165W RHO1
SGTC_97 0535-0701 19.132 µM -1.44532683208083 0.135285054958558 no 2925 0.0741830522625753 4355 2832013 YGL099W LSG1
SGTC_942 3253-1115 227 µM -1.44713276662017 0.134985355522013 no 2926 0.0739298712276329 4492 46497897
SGTC_2391 6285546 200 µM -1.44917445380526 0.134647081135456 no 2927 0.0736444348911997 4469 846083
SGTC_679 0422-0091 41.4 µM -1.45355842756876 0.133922695084058 no 2928 0.0730343848892109 4496 627384 YHR062C RPP1
SGTC_88 0180-0332 8.668 µM -1.45744698952177 0.133282413588871 no 2929 0.0724965170948533 4557 3101745
SGTC_1022 4477-0945 21.3 µM -1.45791791667504 0.13320501505013 no 2930 0.0724315847533228 4416 4648966
SGTC_2955 9076254 12.21 µM -1.46179815148692 0.13256846208566 no 2931 0.0718982654110852 4393 16459619
SGTC_1668 st014914 51.6 µM -1.46435617987444 0.132149965227989 no 2932 0.0715483272483321 4486 2839556
SGTC_398 bronopol 33.3 µM -1.46567520913999 0.131934526595357 no 2933 0.0713683955369902 4402 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_763 3453-1109 128 µM -1.46786863061369 0.131576809047785 no 2934 0.0710699553048164 4509 1560353
SGTC_426 0988-0037 14.6 µM -1.46817695159531 0.131526579754804 no 2935 0.0710280816275409 4496 5383008
SGTC_187 1488-2104 32.728 µM -1.4695561826144 0.131302048044132 no 2936 0.0708409974892841 4466 2852859
SGTC_1179 1021-1431 9.29 µM -1.46965429070512 0.131286086641655 no 2937 0.0708277041709397 4500 2840958
SGTC_2606 farnesol 9.78 µM -1.47141084004094 0.131000536843737 no 2938 0.0705900218105145 4483 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_685 1278-0033 54.9 µM -1.47240366839891 0.130839329715871 no 2939 0.0704559515721789 4536 3590572
SGTC_1954 st077032 68.9 µM -1.47257992382158 0.13081072517793 no 2940 0.0704321707460389 4418 698907
SGTC_1343 1487-0095 224 µM -1.4733229476533 0.130690187167836 no 2941 0.0703319879330501 4476 4560101 YGL055W OLE1
SGTC_226 1,3-diallylurea 8.28947 mM -1.47354020408381 0.130654956973092 no 2942 0.0703027156959373 4442 74537 YKL182W FAS1
SGTC_1886 st057356 49.9 µM -1.47461050069356 0.130481494059714 no 2943 0.0701586450832983 4468 24207747
SGTC_2827 7993847 71.43 µM -1.47762342578132 0.129994044943828 no 2944 0.0697543002976003 4517 2985692
SGTC_1613 st002381 52.1 µM -1.477871020005 0.129954043785861 no 2945 0.0697211522355883 4475 551167
SGTC_1195 1502-0147 41.1 µM -1.47839763696936 0.129868992237355 no 2946 0.0696506887672879 4487 817940
SGTC_2126 5251174 33.877 µM -1.47964397085399 0.12966785599439 no 2947 0.0694841427080714 4462 790722
SGTC_2664 lyso-paf C-16 73.48 µM -1.48111763677893 0.129430310889782 no 2948 0.0692876144330297 4444 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1717 st033143 58.0435 µM -1.48306076866233 0.129117552184426 no 2949 0.0690291330231819 4514 674616
SGTC_3302 9125395 16.351 µM -1.48355341114104 0.129038341760633 no 2950 0.0689637184390138 4443 17599668
SGTC_2401 5128683 200 µM -1.4840502982565 0.128958482993803 no 2951 0.0688977886498286 4480 708373
SGTC_2308 7584454 197.62 µM -1.48761058661369 0.128387282753159 no 2952 0.0684268099486419 4473 893577
SGTC_1672 st016598 6.51 µM -1.49162734357622 0.127744959759924 no 2953 0.0678984329265025 4442 4665860 YNL267W PIK1
SGTC_567 1080-0542 68.4 µM -1.49368284477318 0.127417128212322 no 2954 0.0676292672584074 4373 5950415
SGTC_2254 7938975 95.19 µM -1.4955046835353 0.127127052954326 no 2955 0.0673913892538374 4524 2969277
SGTC_60 0986-0278 202 µM -1.49871198295337 0.126617500290207 no 2956 0.0669741833486491 4451 3110598
SGTC_935 2996-0153 430 µM -1.50031204648426 0.126363826252682 no 2957 0.0667667952162992 4503 23738523
SGTC_814 3342-0569 96 µM -1.50383542374962 0.125806479172247 no 2958 0.06631187383179 4529 4346283
SGTC_1655 st012546 55.1 µM -1.50446622842267 0.125706876288906 no 2959 0.0662306813302688 4483 720985 YLR208W SEC13
SGTC_1417 3966-0327 90.4 µM -1.50930254687177 0.124945058269957 no 2960 0.0656107420826137 4565 651118
SGTC_3316 9136639 10.545 µM -1.51279580653135 0.12439680919941 no 2961 0.065165767175868 4488 4903665
SGTC_1570 verbenone 133 µM -1.51393852427768 0.124217831251558 no 2962 0.0650207160691365 4523 29025 A natural terpanoid with antifungal properties.
SGTC_1158 4092-0494 91.8 µM -1.51929480089662 0.123381306719061 no 2963 0.0643441539129999 4585 1148199
SGTC_2986 9022445 71.43 µM -1.52058259218736 0.123180773857894 no 2964 0.0641823089936305 4480 6459286
SGTC_1427 4048-4900 550 nM -1.52598594864577 0.122341861869162 no 2965 0.0635066819625258 4486 24132586
SGTC_1498 4478-3555 97.6 µM -1.52749642261168 0.122108068215616 no 2966 0.0633188080547216 4507 3437919
SGTC_17 0960-0276 49.807 µM -1.52758044192452 0.12209507278452 no 2967 0.063308370385287 4514 6821114
SGTC_3340 9146634 11.102 µM -1.52927055517483 0.12183386590825 no 2968 0.0630986929785545 4505 4907387
SGTC_3155 9099265 49.47 µM -1.52944778846672 0.121806497276263 no 2969 0.063076736579443 4483 25236499
SGTC_795 0685-0265 78 µM -1.533057252377 0.121250057967085 no 2970 0.0626308745312823 4510 302754
SGTC_1298 1079-1278 263 µM -1.5343934233958 0.121044526301566 no 2971 0.0624664472825647 4490 2840950
SGTC_411 enrofloxacin 100 µM -1.53488773529596 0.12096855271118 no 2972 0.062405703342726 4546 71188 A bacterial gyrase inhibitor.
SGTC_1145 3546-0597 10.2 µM -1.53905400334964 0.120329548414653 no 2973 0.0618955564606078 4491 875334
SGTC_2212 7123476 200 µM -1.54225109630013 0.119840807115107 no 2974 0.0615062938781435 4559 1085715
SGTC_1423 4048-0112 5.59 µM -1.54520545240934 0.119390418888839 no 2975 0.0611482879717302 4574 X1423
SGTC_3232 9132874 49.47 µM -1.54612125426693 0.119251048750091 no 2976 0.061037643296466 4492 3784940
SGTC_1070 indatraline 8.81 µM -1.5487832672826 0.118846585815098 no 2977 0.0607169146212172 4569 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.54990755997049 0.118676053543638 no 2978 0.0605818524324067 4486 364106
SGTC_1956 st077085 54 µM -1.55176059367456 0.11839536354717 no 2979 0.0603597590542085 4547 24208685
SGTC_2423 st077119 87.2 µM -1.55248954582596 0.118285073561899 no 2980 0.0602725661044867 4441 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1583 clindamycin 39.6 µM -1.55299730768639 0.118208292457004 no 2981 0.0602118889071228 4492 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_438 sphingosine 6.67 µM -1.55630147685311 0.11770951400236 no 2982 0.0598182102132462 4461 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1889 st059080 5.18 µM -1.55859263845105 0.117364529052936 no 2983 0.0595464132508222 4491 176925 Isolated from Daphnopsis sellowiana.
SGTC_367 0335-0881 7.1 µM -1.56325635232139 0.116664517571124 no 2984 0.0589961551149528 4460 23828853
SGTC_502 l-744,832 89.3 µM -1.56702704301944 0.116100714947823 no 2985 0.0585541853249169 4541 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1291 0993-0025 5.79 µM -1.5673412077829 0.116053827714659 no 2986 0.0585174791129547 4515 4353356
SGTC_1074 carmofur 3.8 µM -1.57302826343233 0.115207391324806 no 2987 0.0578561369685028 4570 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1900 st060200 72.8 µM -1.57616864317757 0.114741876287195 no 2988 0.0574934714620314 4515 688945
SGTC_1188 1403-0014 4.57 µM -1.57882283222318 0.114349476699226 no 2989 0.0571883499964038 4558 9614867
SGTC_1371 2421-0008 32.7 µM -1.58061963933887 0.114084376768806 no 2990 0.0569825162841459 4534 2827552
SGTC_1959 st077091 55.8 µM -1.58256700301635 0.113797558485768 no 2991 0.0567600946654964 4537 821356 YKL052C ASK1
SGTC_1789 tunicamycin 25 nM -1.58325261240656 0.11369670063886 no 2992 0.056681949528364 4452 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_319 1348-1596 45.5 µM -1.58566140669092 0.113342855712822 no 2993 0.0564080691519107 4592 5380505
SGTC_1851 st056236 18.9 µM -1.58680533544436 0.113175091246073 no 2994 0.0562783700343949 4509 5393171
SGTC_417 st075190 100 µM -1.58780281149648 0.11302894966724 no 2995 0.0561654677663943 4528 222757
SGTC_2690 usnic acid 100 µM -1.58853605574898 0.112921606973198 no 2996 0.0560825873091538 4541 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1663 st014140 55.4 µM -1.58995517740394 0.112714062561508 no 2997 0.0559224543946099 4615 4207120
SGTC_798 1287-0182 476 µM -1.59042682137702 0.112645145683181 no 2998 0.0558693142755763 4577 1649755
SGTC_1475 4092-1048 11.7 µM -1.59286859284436 0.112288833866663 no 2999 0.0555948366625902 4550 2881759
SGTC_2629 bisabolol 100 µM -1.59790543224907 0.111556386551257 no 3000 0.0550320124744918 4548 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_262 fenpropimorph 62.5 µM -1.59986181634582 0.111272816810391 no 3001 0.054814620840297 4578 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3044 9093193 49.47 µM -1.60580583941998 0.110414422071104 no 3002 0.0541582886127972 4547 25236277
SGTC_468 gf-109203x 121 µM -1.60685120646327 0.110263949635197 no 3003 0.0540435060916737 4630 2396 A protein kinase C inhibitor.
SGTC_1623 st003709 20.3 µM -1.60858343225432 0.110014933097583 no 3004 0.0538537296758488 4528 16192618
SGTC_1723 st034307 2.5525 µM -1.60947158246273 0.109887413441045 no 3005 0.0537566319803632 4549 867466
SGTC_3287 9117173 37.0625 µM -1.61104978126967 0.109661079129278 no 3006 0.0535844363217353 4573 2789709
SGTC_2412 st077135 33.4 µM -1.61166958722146 0.109572282459165 no 3007 0.0535169295493556 4559 13258915
SGTC_855 0428-0020 25 µM -1.6160056834239 0.108952514246212 no 3008 0.053046542202779 4571 6812414
SGTC_3326 9140064 16.379 µM -1.6178287614395 0.108692691384894 no 3009 0.0528497531007527 4505 1868434
SGTC_2234 tolnaftate 200 µM -1.61870049769021 0.108568610195948 no 3010 0.0527558598763733 4664 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1045 1348-1485 165 µM -1.62198813389846 0.108101571458641 no 3011 0.0524029444454464 4532 6810614
SGTC_351 caspofungin 25 nM -1.62237552589152 0.108046634292477 no 3012 0.0523614830976535 4553 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1201 1889-3372 45.9 µM -1.62670165107108 0.107434499373674 no 3013 0.0519002389649189 4466 5392199
SGTC_3307 9126885 69.2785 µM -1.62788240550184 0.107267860907388 no 3014 0.0517749114097678 4528 24824909
SGTC_1740 st038286 13.222 µM -1.6286510148475 0.107159488167672 no 3015 0.0516934590664139 4559 716786
SGTC_237 nikkomycin 200 µM -1.62879569159566 0.10713909780064 no 3016 0.0516781385401013 4582 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1905 st060207 84.5 µM -1.6307557346339 0.106863130082638 no 3017 0.0514709355368689 4550 1948547
SGTC_1020 4335-0961 93.3 µM -1.63386922625255 0.106425815543008 no 3018 0.051143156338976 4520 669075
SGTC_1422 4031-0024 15.5 µM -1.6341914412254 0.106380631791604 no 3019 0.051109329557214 4508 782427
SGTC_1101 ebselen 5.29 µM -1.63754108551691 0.105911736219876 no 3020 0.0507587307844528 4583 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3291 9121177 71.43 µM -1.63921469839964 0.105678018085332 no 3021 0.0505842768752002 4538 17015612
SGTC_160 3453-0671 289.699 µM -1.64227616967885 0.105251452476799 no 3022 0.0502663917018387 4552 5322268
SGTC_1506 4226-2149 212 µM -1.64591316356685 0.104746318094183 no 3023 0.0498908191999452 4563 991114
SGTC_2874 9043904 71.43 µM -1.64791631369533 0.104468855715201 no 3024 0.0496849226290661 4487 4463428
SGTC_3145 9085516 49.47 µM -1.6488400196159 0.104341089964751 no 3025 0.0495902069084417 4557 25236195
SGTC_1510 1123-0200 71.5 µM -1.64968409274447 0.10422443796601 no 3026 0.0495037826859926 4564 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_137 0438-0332 85.389 µM -1.65154795702931 0.10396718441489 no 3027 0.0493133683774109 4518 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1171 0368-0077 21.4 µM -1.65206027976625 0.103896553552736 no 3028 0.049261131545671 4543 3239779
SGTC_1016 4226-1401 38 µM -1.65213991672867 0.103885577608462 no 3029 0.0492530156672878 4582 2901613
SGTC_458 nppb 133 µM -1.65413265530895 0.10361120267151 no 3030 0.0490502811946878 4601 4549 A chloride channel blocker.
SGTC_1960 st011366 51.8 µM -1.65670678750228 0.103257556025602 no 3031 0.0487893850371549 4603 3972846
SGTC_665 3914-0008 307 µM -1.66400827163685 0.102259213523477 no 3032 0.0480553882005932 4556 1069549
SGTC_1912 st060209 90.8 µM -1.66594111880203 0.101996111674264 no 3033 0.0478625713486411 4557 688787
SGTC_2675 theaflavin digallate 100 µM -1.67933605830785 0.100186299982677 no 3034 0.0465432836493023 4519 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_884 0851-0618 334 µM -1.68259820955342 0.099749116975724 no 3035 0.0462264492709366 4600 9642473
SGTC_138 0850-0259 40.9225 µM -1.68570882399884 0.099333542095674 no 3036 0.0459259482264939 4525 6813004
SGTC_2557 derrustone 83.84 µM -1.68686549073164 0.0991793359038507 no 3037 0.0458146095136086 4550 629853 An antioxidant.
SGTC_3123 9126162 49.47 µM -1.6917637517983 0.098528242648996 no 3038 0.0453455137605187 4579 25239884
SGTC_3233 9132340 49.47 µM -1.69215396114943 0.09847650960634 no 3039 0.0453083110178769 4599 17682950
SGTC_2238 6671620 73.2395 µM -1.69606244050922 0.0979594294746816 no 3040 0.0449370278505224 4496 729941
SGTC_3181 9108277 49.47 µM -1.69718696464392 0.0978110275396135 no 3041 0.0448306593900479 4578 17097298
SGTC_1005 4092-0690 4.4 µM -1.69830038695962 0.0976642531299822 no 3042 0.0447255408687274 4593 1529343
SGTC_1019 4262-0212 3.4 µM -1.70217883455493 0.0971542464916791 no 3043 0.0443609245813515 4586 4677213
SGTC_2424 5537928 59.2 µM -1.70941211149724 0.0962083143339056 no 3044 0.043687319513139 4597 5382802
SGTC_1268 0828-0275 2.46 µM -1.71204637423848 0.0958655056644493 no 3045 0.0434440613254953 4628 745337
SGTC_1917 st066507 28.5 µM -1.71239987228896 0.0958195718021011 no 3046 0.0434115012963799 4523 3156428
SGTC_236 1509-0011 5.31 µM -1.71431124625773 0.0955714865110719 no 3047 0.0432357893926875 4605 3107280
SGTC_779 1360-0071 233 µM -1.71654086726949 0.0952826922624105 no 3048 0.0430315474078174 4603 7566
SGTC_1554 st069299 38.7 µM -1.72110928461455 0.0946929706412095 no 3049 0.0426154974036436 4561 24207999
SGTC_1733 st037357 54.9 µM -1.72116466130167 0.0946858387901082 no 3050 0.0426104742200112 4522 1272339 YGL099W LSG1
SGTC_373 0844-0104 25.9 µM -1.7231462165387 0.0944308987900491 no 3051 0.0424310434593341 4595 5375804
SGTC_2529 gangaleoidin 93.61 µM -1.72458163428016 0.0942465393072137 no 3052 0.0423014477839689 4574 4565183
SGTC_1235 benzylparaben 21.5 µM -1.72517349699591 0.0941706001077463 no 3053 0.0422481052034461 4639 7180
SGTC_2289 7946404 165.07 µM -1.72717244575167 0.0939144578010091 no 3054 0.0420683489236848 4568 1246120 YPR165W RHO1
SGTC_1686 st019653 115.5 µM -1.7288011215038 0.093706142155856 no 3055 0.0419223476908576 4592 97252
SGTC_1501 4491-0275 38.4 µM -1.73706565886999 0.0926543229521506 no 3056 0.0411877910308414 4610 5104718
SGTC_3148 9097893 49.47 µM -1.73883245821013 0.0924306015787421 no 3057 0.0410321187286601 4567 17174100
SGTC_1664 st014217 9.02 µM -1.73941066223201 0.0923574732398817 no 3058 0.0409812770542944 4669 3982782
SGTC_3216 9129716 49.47 µM -1.74095092953034 0.0921628769317944 no 3059 0.0408460901473491 4515 8056934
SGTC_2726 cimetidine 79.27 µM -1.76070379339349 0.0896941617745719 no 3060 0.0391442751869778 4634 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1953 st076800 12.1 µM -1.7607425189786 0.0896893706151611 no 3061 0.0391409963494541 4579 297591
SGTC_1502 4534-4282 27.7 µM -1.76666325939037 0.0889590884548136 no 3062 0.0386423199443532 4609 3278949
SGTC_201 4262-0159 12.803 µM -1.76695716455477 0.0889229529556595 no 3063 0.0386177011670418 4660 1341029
SGTC_2481 5478948 45.16 µM -1.77020025111814 0.0885249423157657 no 3064 0.0383468937649802 4598 77792
SGTC_2407 paclitaxel 400 µM -1.7702883107391 0.0885141536591592 no 3065 0.0383395621695019 4625 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_574 1315-0397 40 µM -1.77522830280018 0.0879104963809796 no 3066 0.0379300991300422 4602 6794277
SGTC_1174 0739-0097 51.1 µM -1.77579535998851 0.0878414000324101 no 3067 0.0378833263914808 4630 728447
SGTC_2232 chlorophetanol 41.5365 µM -1.77579654612325 0.0878412555434583 no 3068 0.0378832286045424 4691 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2558 carylophyllene oxide 100 µM -1.78019381332968 0.0873068202585934 no 3069 0.0375221237702104 4689 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1196 1588-0294 184 µM -1.78287336316399 0.0869823454656124 no 3070 0.0373034600028342 4656 6144269
SGTC_477 mead ethanolamide 10 µM -1.78319292970348 0.0869437083866108 no 3071 0.0372774515033229 4629 16061185
SGTC_454 lyso-paf C-16 6.67 µM -1.78397628355972 0.086849051501909 no 3072 0.0372137595001607 4618 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_653 0203-0016 55.2 µM -1.78549489601395 0.0866657686957669 no 3073 0.037090539244314 4667 295302
SGTC_2623 humulene 100 µM -1.78776042956793 0.0863928768103955 no 3074 0.0369073337747105 4593 6187145 An anti-inflammatory.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.78838417102476 0.0863178577672171 no 3075 0.0368570241614489 4507 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_165 k038-0023 64.381 µM -1.80270398815649 0.0846089462103305 no 3076 0.0357173577606433 4589 46368543
SGTC_2237 6667747 47.222 µM -1.80493145477278 0.084345419387107 no 3077 0.0355427044514323 4624 729940 YDL015C TSC13
SGTC_3033 9090887 49.47 µM -1.80638568371508 0.0841737052864141 no 3078 0.0354290581127326 4645 19325384
SGTC_2468 5987765 72.9 µM -1.80718126604322 0.0840798747275775 no 3079 0.0353670104651855 4664 26772094
SGTC_682 0kpi-0099 17 µM -1.80745508155762 0.0840475992411111 no 3080 0.0353456761555524 4628 1714895 YML126C ERG13
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.80861675769654 0.0839107723018129 no 3081 0.0352552816180641 4629 6710655
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.81317932764917 0.0833749927142016 no 3082 0.0349020835802617 4712 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_731 3966-0296 387 µM -1.81437379161108 0.0832351532364533 no 3083 0.0348100989321227 4645 660956
SGTC_3329 9141233 27.5565 µM -1.81740264526752 0.0828813468642401 no 3084 0.0345777415027902 4600 4909101 YNL103W MET4
SGTC_655 k060-0012 42 µM -1.82095931759295 0.0824673307002181 no 3085 0.0343065206052023 4643 5994525
SGTC_1940 st075990 51.1 µM -1.82513517689355 0.0819832272243366 no 3086 0.033990316483829 4654 1084979
SGTC_152 4469-0003 551.229 µM -1.83700641387107 0.0806187034292338 no 3087 0.0331044742704936 4624 697280
SGTC_101 0490-5701 117.494 µM -1.84469860101331 0.0797437376901341 no 3088 0.0325406972527153 4530 4661669
SGTC_1381 2324-0066 62.1 µM -1.85060184592802 0.0790771454095658 no 3089 0.032113426983588 4644 10885928
SGTC_3106 9121286 49.47 µM -1.86687962097705 0.0772609291663158 no 3090 0.0309592001686681 4595 15943471
SGTC_893 0958-0369 48.9 µM -1.86988051146133 0.0769295878981547 no 3091 0.0307502063413446 4513 6819948
SGTC_3343 9148379 18.9835 µM -1.87040833047229 0.0768714209907137 no 3092 0.0307135680149845 4659 1955036
SGTC_1053 3366-3204 134 µM -1.87054824648206 0.0768560075220738 no 3093 0.0307038618692344 4646 3632071 YPR165W RHO1
SGTC_2727 riluzole 51.77 µM -1.87108093372952 0.076797346973006 no 3094 0.0306669319384261 4677 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1724 st037281 8.293 µM -1.87742479197275 0.0761013634403631 no 3095 0.0302299481043182 4613 574124 YDL195W SEC31
SGTC_2920 7982904 15.77 µM -1.8797427859138 0.0758482579830378 no 3096 0.0300715706845916 4620 6456808
SGTC_3161 9100388 49.47 µM -1.87990283364928 0.0758308058044881 no 3097 0.0300606608276315 4703 25236368
SGTC_1492 4158-0558 28.5 µM -1.87991750638437 0.0758292059899325 no 3098 0.0300596608062723 4655 3967268
SGTC_832 4083-0019 164 µM -1.88438130212099 0.0753436967286147 no 3099 0.0297567085773489 4683 1990758
SGTC_19 0279-0214 38.434 µM -1.88866389198042 0.0748801271383592 no 3100 0.0294684399207714 4708 3566274 YBR002C RER2
SGTC_41 0478-0632 82.643 µM -1.88898315274512 0.0748456560509594 no 3101 0.0294470430958798 4619 3750424
SGTC_1573 oleylamine 1.06 µM -1.88991685951233 0.0747449117384694 no 3102 0.0293845401723253 4638 5356789 An amine of the fatty acid oleic acid.
SGTC_1129 3453-1384 223 µM -1.89014083164028 0.0747207611749901 no 3103 0.0293695637282924 4625 1084452
SGTC_1816 st051957 91.6 µM -1.89462690250509 0.0742382883084248 no 3104 0.0290709240394158 4665 674121
SGTC_2475 5812728 15.03 µM -1.89887288682958 0.0737838316280433 no 3105 0.0287905954953199 4619 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1136 pergolide 1.05886 µM -1.89950820630046 0.0737160153175759 no 3106 0.0287488443401076 4605 47811 A dopamine receptor agonist.
SGTC_934 2950-0684 338 µM -1.91046043225146 0.072554412132756 no 3107 0.0280369781378384 4659 1121253
SGTC_2001 4023502 57.655 µM -1.91647942668929 0.0719220298512404 no 3108 0.0276520497212344 4633 108941 YCR052W RSC6
SGTC_2460 5552655 174.22 µM -1.91966573483597 0.0715889775523035 no 3109 0.0274500675176782 4638 5401989
SGTC_1868 st057644 42.7 µM -1.92169052009385 0.0713779503979255 no 3110 0.0273223554038819 4679 688665
SGTC_2929 9013348 24.6 µM -1.92279343193249 0.0712632037711541 no 3111 0.0272529986463097 4627 2995952
SGTC_2326 6164455 177.58 µM -1.92487154631346 0.0710473822207627 no 3112 0.027122715198632 4585 2888790
SGTC_2516 gossypol 71.55 µM -1.92639198872845 0.0708897956641203 no 3113 0.0270277234995613 4671 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_10 0279-0212 42.575 µM -1.93091658928357 0.0704224308480964 no 3114 0.0267466841536467 4692 39851 YBR002C RER2
SGTC_956 1185-0240 191 µM -1.93299478392645 0.0702085610109483 no 3115 0.0266184201835622 4649 1416193
SGTC_1629 st005085 44.9 µM -1.93731476328377 0.0697655849643726 no 3116 0.0263534393479118 4639 24207091
SGTC_1326 1431-2094 10.8 µM -1.9386640740478 0.0696276667797289 no 3117 0.0262711279674517 4674 616278
SGTC_467 ro 31-8220 72.8 µM -1.94335034990156 0.0691502948638603 no 3118 0.0259869209277191 4649 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_525 k781-2675 26.7 µM -1.94788860674502 0.068690408591103 no 3119 0.0257141466744402 4622 3651118 YDL195W SEC31
SGTC_2029 5175081 200 µM -1.95135059724752 0.0683411749199082 no 3120 0.0255076769968779 4633 1380876
SGTC_3118 9124250 49.47 µM -1.95770801588062 0.0677034305177047 no 3121 0.0251321420593359 4658 1504786
SGTC_1773 st048542 73.5835 µM -1.96138308485908 0.0673368686294995 no 3122 0.024917175846957 4663 3237138
SGTC_691 1548-0686 185 µM -1.96502251913765 0.0669753748196192 no 3123 0.0247058156121555 4661 46495133
SGTC_2033 5192550 145 µM -1.96609583401479 0.0668690528822132 no 3124 0.0246437707739551 4672 182073
SGTC_2156 5649887 115 µM -1.96866087967807 0.0666154899121933 no 3125 0.0244960232328108 4702 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1269 0831-0796 3.05 µM -1.97363227384639 0.0661261712896564 no 3126 0.0242117856006889 4683 927758
SGTC_1313 1220-0047 237 µM -1.97593578175429 0.0659003903321859 no 3127 0.0240810254744818 4687 3528706
SGTC_2406 ethylparaben 405.7 µM -1.98873261753478 0.0646569559403742 no 3128 0.0233653618692008 4634 8434 A possible steroid mimic.
SGTC_2094 5332512 191.667 µM -1.99238913220695 0.0643050302303545 no 3129 0.0231641894160426 4701 755774
SGTC_2913 7966556 36.57 µM -1.99336298078204 0.0642115524738558 no 3130 0.0231108572350237 4585 2976516
SGTC_1775 st081588 35.1725 µM -2.00152281034283 0.063432451824155 no 3131 0.0226680390530719 4657 1426443 YGL099W LSG1
SGTC_2628 lathosterol 100 µM -2.00267214806373 0.0633233067310859 no 3132 0.0226062450924665 4694 6710616
SGTC_1390 3413-2614 145 µM -2.00384753556175 0.0632118391280345 no 3133 0.0225431975047968 4680 3421432
SGTC_1718 roemerine 11.9335 µM -2.01178106971365 0.0624634557134573 no 3134 0.0221215101544462 4307 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1587 estradiol valerate 56.1 µM -2.01277013525773 0.0623706418574017 no 3135 0.0220694085552303 4720 13791 A steroid.
SGTC_2774 tamoxifen 10.92 µM -2.01714672007046 0.0619612336446769 no 3136 0.0218401021433 4671 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1402 3909-7673 35.9 µM -2.02111030974992 0.0615922715837472 no 3137 0.0216341736725004 4694 5328014
SGTC_1964 st076914 61 µM -2.02354736069385 0.0613662649047654 no 3138 0.0215083729320347 4716 24208661
SGTC_3305 9127027 53.8275 µM -2.03062334305765 0.0607137244890046 no 3139 0.0211466089542916 4658 41905295
SGTC_964 1287-0107 19.4 µM -2.03490084082174 0.060321897406968 no 3140 0.0209304256937338 4681 51516812 YPR165W RHO1
SGTC_1901 st060216 58.6 µM -2.03547233112556 0.0602696980010815 no 3141 0.0209016849198719 4676 688792
SGTC_1962 st076595 64.5 µM -2.03928679261096 0.059922193604819 no 3142 0.0207107065043203 4662 279619
SGTC_916 4466-0038 42 nM -2.04288096559037 0.0595961957352237 no 3143 0.0205321115054167 4710 5722064 YGL116W CDC20
SGTC_2773 thioridazine 9.09 µM -2.04319668732029 0.0595676257508487 no 3144 0.0205164857759423 4689 5452 An antipsychotic.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.04376805829632 0.0595159490944774 no 3145 0.0204882330456616 4649 6708514
SGTC_1230 0170-0365 3.77 µM -2.05360814739905 0.0586314818152728 no 3146 0.0200068164785571 4697 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1980 st071811 45.7 µM -2.0536838324059 0.0586247191470118 no 3147 0.020003151176963 4729 4974850
SGTC_1670 st016595 4.04 µM -2.06658668427787 0.0574807368040925 no 3148 0.0193865582955197 4723 597879
SGTC_3072 9116419 49.47 µM -2.06960666095251 0.057215534779093 no 3149 0.0192445968975775 4690 17170162
SGTC_3081 9117243 49.47 µM -2.07096246658967 0.057096787105978 no 3150 0.0191811518744243 4661 45595589
SGTC_2314 7727897 200 µM -2.07859346805323 0.0564320440604946 no 3151 0.0188273659321729 4667 900724
SGTC_2473 5854593 8.94 µM -2.08021384429685 0.0562916798996642 no 3152 0.0187529614861678 4695 2872951
SGTC_2058 5236698 133 µM -2.0845708970403 0.0559156175511438 no 3153 0.0185541342585639 4686 766665
SGTC_2267 7931562 200 µM -2.0871299222269 0.0556956706356299 no 3154 0.0184381959654246 4669 934880
SGTC_1080 nisoldipine 24.4 µM -2.08792556253135 0.0556274250761309 no 3155 0.0184022749424369 4734 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1047 2043-3044 82 µM -2.09153149833545 0.0553189551958887 no 3156 0.0182402229496964 4672 669592
SGTC_208 k072-0098 12.366 µM -2.09252957887722 0.0552338134969767 no 3157 0.0181955843166473 4713 5948901
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.09736110331622 0.0548231205024352 no 3158 0.0179808107945134 4736 16725076
SGTC_1253 0550-0034 176 µM -2.09992094102294 0.0546065074768174 no 3159 0.0178678981495918 4683 5969915
SGTC_117 lucigenin 22.078 µM -2.10392013591043 0.0542694514842515 no 3160 0.0176927070963389 4659 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_784 4579-0127 173 µM -2.10826218095041 0.05390536583636 no 3161 0.0175041586647609 4714 1948547
SGTC_2131 toluylene red 5.2905 µM -2.11385476877637 0.0534392733772998 no 3162 0.0172638367282126 4663 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2350 9023895 38.85 µM -2.11461784095699 0.0533759264374519 no 3163 0.0172312659145004 4675 2997209
SGTC_1213 1315-0166 115 µM -2.11651836916545 0.0532184115135368 no 3164 0.017150372297808 4699 768401
SGTC_2528 xanthyletin 44.79 µM -2.11721214193885 0.0531610038311411 no 3165 0.0171209236859754 4709 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3349 9149703 23.001 µM -2.11924991087098 0.0529926682261295 no 3166 0.0170346761439607 4712 4910494
SGTC_1945 st075991 56.6 µM -2.11959507844141 0.0529641966052195 no 3167 0.017020103943448 4696 1084980
SGTC_2235 salicylic acid 500 µM -2.12062108100198 0.0528796369998703 no 3168 0.0169768513149241 4749 338 A COX inhibitor and kinase inhibitor.
SGTC_3348 9149464 3.537 µM -2.12125810655567 0.0528271894511058 no 3169 0.016950043889528 4677 1951442
SGTC_2513 baicalein 25.65 µM -2.12654473097039 0.0523935221517339 no 3170 0.0167289644368343 4677 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_902 1120-0002 2.07 µM -2.13254790483041 0.051904507765892 no 3171 0.0164809153642729 4698 3280475
SGTC_1884 5633444 25 µM -2.13612300095904 0.0516150104346042 no 3172 0.0163346947129319 4665 5724239
SGTC_374 0880-0231 82.3 µM -2.14374264281684 0.0510022857711784 no 3173 0.0160267566920755 4607 6833587
SGTC_1165 k072-0275 30.3 µM -2.14384247933572 0.0509942961278089 no 3174 0.0160227551803029 4708 6153523 YGL055W OLE1
SGTC_1522 st012842 45.6 µM -2.16816181605195 0.0490775773876029 no 3175 0.0150731884566984 4585 3491067 YOR116C RPO31
SGTC_899 1083-0020 478 µM -2.16987502252883 0.0489447512917703 no 3176 0.0150081574947242 4742 767123
SGTC_1283 0922-0125 16.4 µM -2.17417484383353 0.0486126480180333 no 3177 0.0148460034268867 4709 3360884
SGTC_1950 st077106 7.18 µM -2.17807562802981 0.048312925787613 no 3178 0.0147002033711619 4658 13831864
SGTC_3333 9141820 12.094 µM -2.18259578312611 0.0479674641961841 no 3179 0.0145327953030305 4697 1939433
SGTC_2488 5268135 45.7 µM -2.18536654510162 0.0477566826879397 no 3180 0.0144309908900357 4725 1270356 YLR208W SEC13
SGTC_358 0075-0058 9.45 µM -2.18814647374175 0.0475459498466261 no 3181 0.0143294672979153 4678 1069125
SGTC_2841 9004761 38.96 µM -2.18927485103886 0.0474606258850885 no 3182 0.0142884345554201 4661 2991039
SGTC_120 rhodamine 6G 52.259 µM -2.19004202672321 0.0474026848207381 no 3183 0.0142605945132715 4714 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2112 5488546 200 µM -2.19181804181401 0.0472687684769633 no 3184 0.0141963239207048 4702 600757
SGTC_819 1013-0258 27.7 µM -2.2058777359736 0.0462193009583595 no 3185 0.0136962807451202 4725 5753198
SGTC_320 4092-0846 5.34 µM -2.20673480177991 0.0461559363640087 no 3186 0.0136662961842473 4695 1359356
SGTC_848 0368-0089 85.6 µM -2.20762301318988 0.046090342749979 no 3187 0.0136352817716734 4721 762535
SGTC_2147 5545932 89.7195 µM -2.20957087614116 0.0459467569711675 no 3188 0.0135674792100672 4748 797404
SGTC_607 4491-0986 66.8 µM -2.21318710213512 0.0456811417237493 no 3189 0.0134423744724288 4716 698981 YDR232W HEM1
SGTC_298 1391-0729 10 µM -2.21429836000015 0.0455997671618703 no 3190 0.013404130686325 4701 3237558
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.22322442055576 0.0449503545920085 no 3191 0.0131003354633783 4732 2333 A French combination drug.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.22994597768115 0.044466260578625 no 3192 0.012875514759184 4682 6708739 YPR165W RHO1
SGTC_2902 5787006 60.46 µM -2.23031126901263 0.0444400727045685 no 3193 0.0128633927849956 4718 591003
SGTC_147 4466-0538 29.23 µM -2.2327665368933 0.0442643759363743 no 3194 0.012782172041251 4713 6742687 YHR072W ERG7
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.23976958662699 0.0437663182186843 no 3195 0.0125529426456332 4699 6728940
SGTC_278 4092-0821 23.9 µM -2.24604922091279 0.0433235638556662 no 3196 0.0123504276744298 4708 877900
SGTC_200 k038-0079 37.545 µM -2.25397819224131 0.0427696945292619 no 3197 0.0120987699680745 4750 3436683
SGTC_3290 9121031 71.43 µM -2.25789603630864 0.0424981383829881 no 3198 0.0119760709009235 4722 17014854
SGTC_280 3448-3607 3.04 µM -2.2615970277509 0.0422428952610125 no 3199 0.0118611559111055 4726 626179
SGTC_1999 st074831 12.5 µM -2.26332391672698 0.0421242235173555 no 3200 0.0118078645054582 4717 17112523
SGTC_3264 9137442 49.47 µM -2.26777546687089 0.0418195570221524 no 3201 0.01167144771466 4695 17015726
SGTC_455 paf C-16 10 µM -2.26898167585495 0.0417373113986965 no 3202 0.011634720108056 4709 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_478 N-arachidonylglycine 10 µM -2.27533126965676 0.041306520393814 no 3203 0.0114430324890103 4769 5283389
SGTC_3242 9133940 49.47 µM -2.27674254231105 0.041211263206792 no 3204 0.0114008022308135 4748 17248444
SGTC_2207 7258803 200 µM -2.28408253277323 0.0407187012788964 no 3205 0.0111833404647041 4754 3666799
SGTC_1105 epirubicin 18.1 µM -2.28463960566596 0.0406815138890329 no 3206 0.0111669843000053 4750 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2268 7933382 153.85 µM -2.29100501460719 0.0402585449138446 no 3207 0.0109815618174165 4733 935025 YOR257W CDC31
SGTC_2969 9091408 28.7 µM -2.29934149848171 0.0397100114225929 no 3208 0.0107427775506059 4687 4286311
SGTC_2183 6420625 130.508 µM -2.30038693989419 0.0396416531424166 no 3209 0.0107131540368897 4758 2897619
SGTC_1052 3253-3998 198 µM -2.30293119805418 0.0394756914991344 no 3210 0.0106413572453953 4714 5450317
SGTC_2973 9094665 17.96 µM -2.30718287786366 0.039199616703574 no 3211 0.0105223136023032 4705 25237061 YIL048W NEO1
SGTC_2421 5690543 90.72 µM -2.3139771124227 0.0387617096664428 no 3212 0.0103344888184325 4696 3397993
SGTC_2213 7173844 200 µM -2.31465100198173 0.0387184937228113 no 3213 0.010316019645578 4752 892728
SGTC_2518 prenyletin 46.28 µM -2.31520551158927 0.0386829629552979 no 3214 0.0103008438882992 4757 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2815 7968870 71.43 µM -2.31642231627081 0.0386050880580158 no 3215 0.0102676107246536 4691 2977326 YHR190W ERG9
SGTC_218 alverine citrate 93.75 µM -2.31745931153947 0.0385388217432531 no 3216 0.0102393623212122 4751 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1407 3909-7909 12.3 µM -2.31987974110914 0.0383845115388466 no 3217 0.0101736918969684 4741 4411780
SGTC_1106 tegaserod maleate 11.7 µM -2.32123542948159 0.0382983023230428 no 3218 0.0101370705003183 4751 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_608 k048-0125 159 µM -2.3340388220914 0.0374918868230637 no 3219 0.00979684460003579 4758 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2022 5136654 200 µM -2.33540236049823 0.0374068281167949 no 3220 0.00976120561722248 4712 1713771
SGTC_515 4092-1064 102 µM -2.35104160942163 0.0364424642375617 no 3221 0.00936047012650651 4698 717353
SGTC_2702 st077768 96.8 µM -2.35453595394374 0.0362297968529315 no 3222 0.00927292474203916 4730 6484119
SGTC_1081 sertraline 6 µM -2.35626173535022 0.0361251404415638 no 3223 0.00922995288608753 4729 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3259 9138485 49.47 µM -2.36268046431261 0.0357380605832511 no 3224 0.0090716527593263 4721 17646153
SGTC_805 3852-0218 479 µM -2.36837745434823 0.0353973583117841 no 3225 0.0089331490228572 4746 6615355
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -2.37475463773634 0.0350191421514996 no 3226 0.0087803095228774 4749 689007
SGTC_1902 st060212 70.5 µM -2.38439629823312 0.0344536205087082 no 3227 0.00855358438318653 4742 688944
SGTC_2165 5727197 32.143 µM -2.4002040009988 0.0335426865768583 no 3228 0.00819296853627345 4726 1361712
SGTC_673 1082-0474 110 µM -2.42257872211594 0.0322872986075063 no 3229 0.00770539319424058 4738 3098046
SGTC_406 estrone 100 µM -2.44809390329403 0.030903291907175 no 3230 0.0071807110553835 4742 5870 A steroid.
SGTC_2008 4012253 172 µM -2.45405987968561 0.030586865604763 no 3231 0.00706267289828974 4738 603940
SGTC_861 0443-0273 110 µM -2.46572252084031 0.0299760456216753 no 3232 0.0068368606977975 4741 6149169
SGTC_3249 9135183 49.47 µM -2.4689266294016 0.0298100159777173 no 3233 0.00677595007715574 4737 4902779
SGTC_354 2783-3500 4.88 µM -2.46930764265863 0.0297903235841207 no 3234 0.00676873894509345 4743 6740761
SGTC_3321 9137793 26.8275 µM -2.49864152492619 0.0283063045590851 no 3235 0.00623351755815563 4762 4904192
SGTC_3041 9091929 49.47 µM -2.50033862636785 0.0282223643400128 no 3236 0.00620373229286485 4730 25236887
SGTC_2884 9058502 51.95 µM -2.50051413741785 0.0282136952344999 no 3237 0.0062006591602662 4752 6471554
SGTC_2486 5283202 22.39 µM -2.52256124957234 0.0271422048885613 no 3238 0.00582518296555309 4750 1377751
SGTC_2924 9010168 62.78 µM -2.53212845949852 0.0266879164370291 no 3239 0.00566862240481175 4744 2993929
SGTC_577 r071-0003 38.6 µM -2.53636172637528 0.0264889406166883 no 3240 0.00560054838053796 4754 4568517 YMR134W ERG29
SGTC_2878 9043973 25.97 µM -2.54295864567222 0.0261813382041582 no 3241 0.00549591187786777 4738 6465167
SGTC_91 0417-1751 58.384 µM -2.5676781402916 0.0250551536125321 no 3242 0.00511910843922093 4783 6795624
SGTC_905 2-aminofluorene 215 µM -2.57616542095273 0.0246779724177062 no 3243 0.00499514193212034 4774 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3047 9092122 49.47 µM -2.58097780613903 0.0244662307920459 no 3244 0.00492604576534145 4751 17173831
SGTC_1330 1469-0054 61.8 µM -2.58630174918278 0.0242337598693829 no 3245 0.00485059801257577 4748 7102664
SGTC_2938 9059746 27.26 µM -2.59807689959674 0.0237261788798271 no 3246 0.00468737483447765 4750 6471769
SGTC_1499 4480-0877 67.3 µM -2.60560858932715 0.0234062276529577 no 3247 0.00458555988287551 4787 2861909
SGTC_3151 9099821 49.47 µM -2.60929938719425 0.0232507703030096 no 3248 0.00453639131547004 4740 17174189
SGTC_118 0083-0097 135.343 µM -2.63957691628358 0.0220079873959652 no 3249 0.00415047921164636 4736 5207356
SGTC_1578 josamycin 24.2 µM -2.65246512783186 0.0214962481220606 no 3250 0.00399531907597758 4770 5282165 A P450 substrate.
SGTC_1989 st071868 50.2 µM -2.67305210326719 0.0206996989417611 no 3251 0.00375822875153911 4776 16414057
SGTC_3339 9145883 14.936 µM -2.67599927729575 0.0205877385829351 no 3252 0.00372534028966154 4751 2030670
SGTC_1192 1488-0095 21.4 µM -2.68803515318649 0.0201358176054037 no 3253 0.0035936914854507 4789 915875
SGTC_2111 5486399 200 µM -2.69216695615804 0.0199826297416472 no 3254 0.00354946989213073 4758 689674
SGTC_2286 7945697 125 µM -2.7386680883201 0.0183256984720926 no 3255 0.00308443085516637 4741 1245733
SGTC_2584 androsterone 48.74 µM -2.74455440562125 0.0181245478854237 no 3256 0.00302965548765838 4718 2754130 A steroid.
SGTC_2779 methotrexate 400 µM -2.74476931320901 0.0181172396909943 no 3257 0.00302767234015751 4762 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2511 berberine 10.47 µM -2.80827961083133 0.0160647183533386 no 3258 0.00249034803862988 4759 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2900 5328528 85.29 µM -2.81703585079025 0.0157979974946961 no 3259 0.00242345575269944 4756 795359
SGTC_3075 9116269 49.47 µM -2.82882289095485 0.0154449602295579 no 3260 0.00233597729125822 4766 17015205 YNL244C SUI1
SGTC_794 k038-0031 316 µM -2.83690095646109 0.0152069416764691 no 3261 0.00227768703585889 4779 6624242
SGTC_2834 9001755 58.44 µM -2.84554239581132 0.0149558185070235 no 3262 0.00221679285575924 4677 2989575
SGTC_2859 9028643 45.46 µM -2.8483345391433 0.0148754436193727 no 3263 0.00219743498188626 4722 17151580
SGTC_838 0109-0203 71.4 µM -2.88275769834132 0.0139146552735771 no 3264 0.00197105271072024 4799 759422
SGTC_255 tunicamycin 200.472 nM -2.89397253919432 0.0136134165002608 no 3265 0.00190200714411218 4759 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3222 9128301 49.47 µM -2.90053609279388 0.0134397386204561 no 3266 0.001862624670076 4761 4911358
SGTC_2053 5265679 138 µM -2.905978711792 0.0132971759244665 no 3267 0.00183053177971859 4763 764595
SGTC_1637 st007924 17.4 µM -2.90598828974556 0.0132969261976479 no 3268 0.0018304757484084 4748 683336
SGTC_974 1326-0144 138 µM -2.92069996303692 0.0129180978763778 no 3269 0.00174622996257829 4796 5411856
SGTC_501 nsc-95397 161 µM -2.93822689045536 0.0124789909316271 no 3270 0.00165047674702863 4788 262093
SGTC_2115 tiliquinol 12.7705 µM -2.94084304331989 0.0124145689762414 no 3271 0.00163660171621624 4774 71208 A bioactive hydroxyquinoline.
SGTC_622 1348-1566 26.3 µM -2.94256349614072 0.0123723605239059 no 3272 0.00162753512692778 4792 7340407
SGTC_3219 9131112 49.47 µM -2.95247594760431 0.0121315882355938 no 3273 0.00157618313869623 4720 17612988 YMR079W SEC14
SGTC_2464 5717415 7.67 µM -2.96749863690628 0.0117744329867138 no 3274 0.00150116806907429 4776 5285744
SGTC_3270 9137563 49.47 µM -3.00788548006236 0.0108591471876495 no 3275 0.00131536125855074 4791 17015724
SGTC_2993 9054257 71.4286 µM -3.02290489123702 0.0105349125512412 no 3276 0.00125180457332654 4762 6470217 YGL055W OLE1
SGTC_1867 st057372 64 µM -3.0324637233173 0.0103329801527023 no 3277 0.00121283125533882 4795 688837
SGTC_2241 6772625 37.8075 µM -3.03540990191705 0.0102714256869212 no 3278 0.00120104490203691 4696 2285411
SGTC_68 0986-0284 82.829 µM -3.04436826200499 0.0100862190400307 no 3279 0.00116584762682386 4738 423278 YIL048W NEO1
SGTC_2283 7944793 200 µM -3.06298378715492 0.00971065606218351 no 3280 0.00109570966177674 4782 2970533
SGTC_203 k066-0004 30.888 µM -3.0664408083493 0.00964227315842075 no 3281 0.00108311847027082 4796 6795412
SGTC_2422 chlorphenesin carbamate 384.24 µM -3.086097107322 0.00926139797232327 no 3282 0.00101401288993906 4744 2724 A muscle relaxant with antifungal properties.
SGTC_64 000l-0018 272.079 µM -3.09954478882663 0.00900847125117923 no 3283 0.000969091355455183 4746 6811119
SGTC_2619 obliquin 87.91 µM -3.11618490616446 0.00870389093427996 no 3284 0.000916036776625236 4788 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1827 berberine 7.24 µM -3.13443732068328 0.00838021912036928 no 3285 0.000860920171093774 4768 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_978 1416-0512 87.4 µM -3.16291350375206 0.00789633970784068 no 3286 0.000780993665722466 4795 6814003
SGTC_690 glyoxal 20.3 µM -3.16777869925399 0.00781617314163931 no 3287 0.000768041997886566 4718 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1933 st074711 15.9 µM -3.17300761351588 0.00773081256241403 no 3288 0.000754342840411688 4783 17250958
SGTC_3308 9128332 17.569 µM -3.19168333497093 0.00743259770015206 no 3289 0.000707231563968389 4779 17332805 YDL196W YDL196W
SGTC_971 1315-0384 26.7 µM -3.19366299430822 0.00740158845945099 no 3290 0.000702400039431886 4803 6769120
SGTC_279 1273-0055 2.93 µM -3.20359464730249 0.0072477342899125 no 3291 0.000678617101094934 4798 2847562
SGTC_576 1073-0113 22.7 µM -3.24734890332542 0.00660300313271812 no 3292 0.000582427479082531 4802 5439563
SGTC_1161 k007-0610 110 µM -3.27984431552314 0.006157529039822 no 3293 0.000519321923154952 4771 5843850
SGTC_2105 5350118 200 µM -3.291466135545 0.00600479419655297 no 3294 0.000498333078097232 4802 2133313
SGTC_3141 9094609 49.47 µM -3.29992264285175 0.00589577863793165 no 3295 0.000483557412414198 4792 25236309 YDL196W YDL196W
SGTC_1 0258-0098 57.368 µM -3.31581301041516 0.00569566968986628 no 3296 0.000456884736308788 4733 6790032 YDR047W HEM12
SGTC_1949 st076024 69.1 µM -3.34661785134905 0.0053248423594989 no 3297 0.000409019492242745 4782 2921930
SGTC_2890 9046729 58.44 µM -3.3547137922518 0.00523101736084895 no 3298 0.000397235679788627 4800 903329
SGTC_768 0384-0033 77.3 µM -3.36641270080127 0.00509803530968379 no 3299 0.000380763410320739 4797 3965305 YMR134W ERG29
SGTC_1786 berberine 21.6 µM -3.39947068247509 0.00473838577476459 no 3300 0.000337582088106216 4759 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2019 4016004 108 µM -3.48838893884111 0.00388071769950986 no 3301 0.000242970325490159 4792 45595336
SGTC_1547 harmine 94.2 µM -3.54904225552947 0.0033783529001397 no 3302 0.000193317515741449 4771 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2597 laccaic acid a 100 µM -3.56123398731133 0.00328472938353447 no 3303 0.000184557976587115 4790 5491415 A textile dye.
SGTC_327 1273-0057 3.96 µM -3.56848120946385 0.00323018817633564 no 3304 0.000179528299604879 4792 3108138
SGTC_2813 7971799 71.43 µM -3.61484181657381 0.00290014957524518 no 3305 0.000150265531297167 4787 2234054
SGTC_3097 9117246 49.47 µM -3.64107130371039 0.00272719339933811 no 3306 0.00013575296104436 4807 16423892
SGTC_435 c-PAF 6.7 µM -3.66615049999964 0.00257058694366856 no 3307 0.000123114524392577 4779 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1978 st071761 42 µM -3.67095063889957 0.00254155613666585 no 3308 0.000120825005005192 4805 5147680
SGTC_308 4092-1169 104 µM -3.7412832740278 0.00214886033692434 no 3309 9.15415096161908e-05 4800 2268590 YDL196W YDL196W
SGTC_2439 5492030 7.2 µM -3.74201263147057 0.00214509351007621 no 3310 9.12761684907708e-05 4807 5722370
SGTC_932 2857-0803 154 µM -3.74545384392274 0.00212740172592825 no 3311 9.00339762476992e-05 4802 674898
SGTC_2803 7707263 71.43 µM -3.78493080781853 0.00193370402437692 no 3312 7.6875674957438e-05 4797 2199229
SGTC_1821 st053465 65.6 µM -3.81401944185591 0.00180138532460878 no 3313 6.83623524901979e-05 4804 675086
SGTC_837 0091-0265 12.5 µM -3.87478292703973 0.00155117893658782 no 3314 5.33598938826829e-05 4807 759367
SGTC_339 3091-4833 71.4 µM -3.9124851102055 0.00141230653889073 no 3315 4.56755861643432e-05 4761 3240077
SGTC_1026 k007-1105 30.6 µM -3.91625410761535 0.00139906729819711 no 3316 4.49677272421287e-05 4795 7066794
SGTC_637 1181-0519 7.26 µM -3.97599930311408 0.00120379439531249 no 3317 3.50421651433475e-05 4809 6252091 YGR060W ERG25
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -4.01796390342006 0.0010819136754578 no 3318 2.9351593428608e-05 4808 688669
SGTC_660 4031-1742 102 µM -4.05020282701516 0.000996081565824996 yes 3319 2.55866294078298e-05 4798 6738706
SGTC_1550 gossypolone 36.6 µM -4.07865470392344 0.000925571776112625 yes 3320 2.26485277638913e-05 4810 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1162 k048-0130 20.1 µM -4.08165163207825 0.000918418106963555 yes 3321 2.23583943807487e-05 4807 6797406
SGTC_1951 sophoraflavanone G 9.2 µM -4.11154222860747 0.000849798658409413 yes 3322 1.96512485017052e-05 4791 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_514 4466-0038 2.65 nM -4.13595203264431 0.000797294273007373 yes 3323 1.76743015388533e-05 4775 5722064
SGTC_648 0375-0473 33.3 µM -4.16249020251512 0.00074361169880759 yes 3324 1.57397826353094e-05 4810 1713139
SGTC_1160 4092-0570 10.5 µM -4.19223956186375 0.00068740460807318 yes 3325 1.38107046003082e-05 4798 4994975
SGTC_3200 9114385 49.47 µM -4.248990632395 0.000590902260619691 yes 3326 1.07367948712862e-05 4803 17018030 YLR208W SEC13
SGTC_2249 haloperidol 116.36 µM -4.28462089555144 0.000536881544223406 yes 3327 9.15255250635043e-06 4794 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_917 harmaline 728.087 nM -4.30350898133149 0.000510133426367854 yes 3328 8.40570148406121e-06 4779 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_58 0957-0393 9 µM -4.31736290111714 0.000491304416136542 yes 3329 7.89522130225022e-06 4652 6997992
SGTC_1033 k072-0102 21.3 µM -4.34951891432186 0.00045005379254892 yes 3330 6.82182581194497e-06 4806 5965931
SGTC_609 0986-0026 86.3 µM -4.35303907835522 0.000445738493438807 yes 3331 6.71316030492405e-06 4802 2848610
SGTC_314 1671-0008 2.74 µM -4.40909312184267 0.000381991388462456 yes 3332 5.1902193028107e-06 4796 3913060
SGTC_1712 st032288 53.4 µM -4.43857641753283 0.000351964409002973 yes 3333 4.52779166252974e-06 4788 2883011
SGTC_304 1310-0298 97 µM -4.54392215663848 0.000261677330680318 yes 3334 2.76085279774664e-06 4765 1550234
SGTC_601 0986-0029 62.9 µM -4.55046527897976 0.000256852060487994 yes 3335 2.6763709877098e-06 4806 24747981
SGTC_431 k089-0097 107 µM -4.68977589346877 0.000171853207133958 yes 3336 1.36752217085443e-06 4736 5499420
SGTC_568 1193-0097 7.48 µM -4.69756851507989 0.000167980201135682 yes 3337 1.31638440951307e-06 4781 3646150
SGTC_2582 agaric acid 100 µM -4.79741093011255 0.000125064357370205 yes 3338 8.03648214321907e-07 4748 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2250 alverine citrate 130 µM -4.86289370363358 0.000102755121182927 yes 3339 5.78409888606784e-07 4794 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1990 st072050 59.8 µM -5.11686765627338 4.6892169662194e-05 yes 3340 1.55325715016942e-07 4810 17233948
SGTC_103 0844-0104 51.839 µM -5.11853619847753 4.664559539771e-05 yes 3341 1.53958072110588e-07 4795 5375804
SGTC_2887 9044784 58.44 µM -5.3050165843488 2.56257035464567e-05 yes 3342 5.63313764486788e-08 4810 6465546
SGTC_2566 crystal violet carbinol 226 nM -5.45252895227227 1.57378569721944e-05 yes 3343 2.48292420026663e-08 4801 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -5.52964213331761 1.21384887301642e-05 yes 3344 1.6044236023812e-08 4809 676296 Flavone; oxidizing agent.
SGTC_2021 4019055 173 µM -5.73416591572432 5.99864407314086e-06 yes 3345 4.89966854551196e-09 4802 44827708 YER133W GLC7
SGTC_3266 9136860 49.47 µM -6.10237931077371 1.58963658729675e-06 yes 3346 5.22505067750674e-10 4792 4871271 YPR165W RHO1
SGTC_649 1123-0311 367 µM -6.10592034417739 1.56888412218083e-06 yes 3347 5.11049884690765e-10 4810 693629 YIL048W NEO1
SGTC_299 1273-0059 1.44 µM -6.2566190139753 8.90996616858862e-07 yes 3348 1.96706452967575e-10 4800 2848077
SGTC_2943 9068529 45.32 µM -6.4535824860025 4.1721102971517e-07 yes 3349 5.46182503031428e-11 4809 3270634
SGTC_2679 rapamycin 1 nM -6.75114913812244 1.2720463800394e-07 yes 3350 7.33393639909743e-12 4799 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1844 rapamycin 4 nM -7.20020809936469 1.92689125086575e-08 yes 3351 3.00603660858604e-13 4800 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2944 9067346 25.62 µM -7.37829655675008 8.83191514518443e-09 yes 3352 8.016377058341e-14 4810 6473075
SGTC_310 1273-0058 1.06 µM -7.64589226269366 2.64400863275618e-09 yes 3353 1.03750677851723e-14 4776 2734232
SGTC_1597 7-benzyloxygramine 47.5 µM -7.79669338199743 1.31611630604461e-09 yes 3354 3.17752016085562e-15 4810 260807
SGTC_2948 9070189 9.45 µM -10.0314104655996 9.30071798802608e-15 yes 3355 5.54603142156069e-24 4810 6473636 YDL196W YDL196W
SGTC_2896 9052656 71.43 µM -15.231461889241 1.41972908964565e-31 yes 3356 1.09323655031848e-52 4808 6469436