SGTCid condition conc unit UTP5|YDR398W.score UTP5|YDR398W.strain.pval UTP5|YDR398W.strain.significant UTP5|YDR398W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1712 st032288 53.4 µM 11.6111455559951 2.77845787578923e-30 yes 1 1.80868257239786e-31 2 2883011
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 9.88962791951879 1.57839396161979e-22 yes 2 2.30870436124222e-23 7 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2360 9040895 200 µM 9.31227678485516 3.36487952913849e-20 yes 3 6.25604830686142e-21 1 4914414
SGTC_2583 asiatic acid 100 µM 7.59242523840503 4.53992085584652e-14 yes 4 1.5698632122284e-14 1 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2585 alliin 100 µM 7.1011265172648 1.53786188042133e-12 yes 5 6.18720142368343e-13 1 87310 A garlic compound which reacts with lipids.
SGTC_2358 9037157 4 µM 6.55571000466368 5.89589412878232e-11 yes 6 2.7688877847633e-11 2 2388925
SGTC_1374 2889-5571 141 µM 5.15295752598729 1.95644068832854e-07 yes 7 1.28205028213104e-07 26 2853281
SGTC_2688 kanamycin b 96.69 µM 4.96870134289548 4.95679217839961e-07 yes 8 3.37013948452623e-07 5 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_497 capsazepine 133 µM 4.88218130938698 7.58748385772205e-07 yes 9 5.24593592443222e-07 3 2733484 A calcium channel blocker.
SGTC_1230 0170-0365 3.77 µM 4.74805858448412 1.44816889315291e-06 yes 10 1.02689276072428e-06 17 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2692 st077426 47.7 µM 4.61361920782888 2.72276415991888e-06 yes 11 1.97858565270577e-06 4 25238571
SGTC_1246 0422-0085 105 µM 4.43881209720933 6.03645881653297e-06 yes 12 4.52283720831187e-06 5 264295
SGTC_2198 6589944 200 µM 4.24162728905909 1.43307256257831e-05 yes 13 1.10952489222963e-05 1 5290268
SGTC_325 2810-4341 181 µM 4.03072467899023 3.4742117941759e-05 yes 14 2.7802573523083e-05 5 774970
SGTC_2322 7413319 38.22 µM 3.94457605340801 4.93066015072247e-05 yes 15 3.99706400072201e-05 25 1840400
SGTC_2839 9003951 25.97 µM 3.85351403056482 7.08681976023153e-05 yes 16 5.82172939565512e-05 3 2990634
SGTC_2061 5245884 80.95 µM 3.75899193432253 0.000102456489976923 yes 17 8.52996683775516e-05 7 573863
SGTC_784 4579-0127 173 µM 3.72687892703643 0.000115912586799253 yes 18 9.69327627108365e-05 5 1948547
SGTC_3014 9081533 49.47 µM 3.60704063343685 0.00018220335668315 yes 19 0.000154854587646491 5 21367265
SGTC_445 e6 berbamine 66 µM 3.57293287630991 0.000206745402551597 yes 20 0.000176502635358138 33 6610268 A calcium/calmodulin antagonist.
SGTC_2143 5623677 140.463 µM 3.55917805906003 0.000217489806162497 yes 21 0.000186008628119171 3 5375313
SGTC_302 1094-0063 18.9 µM 3.55139107671153 0.000223801354995358 yes 22 0.0001916002835517 24 5440289
SGTC_886 0866-0150 153 µM 3.51843796370432 0.000252450491747957 yes 23 0.000217047648402341 2 271463
SGTC_800 3448-7362 155 µM 3.47070173995196 0.000300059588241208 yes 24 0.000259550120526307 56 15991913
SGTC_2840 9008771 71.43 µM 3.42315171473371 0.000355683843695761 yes 25 0.000309497593554364 2 2992978
SGTC_355 1311-2252 105 µM 3.41724339035329 0.000363228365559267 yes 26 0.000316293489720003 7 5338538
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 3.40663896097807 0.00037714355366891 yes 27 0.00032884030777719 22 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2021 4019055 173 µM 3.32793232307003 0.000496959240105265 yes 28 0.000437465591657196 48 44827708 YER133W GLC7
SGTC_2847 9005661 71.43 µM 3.30593645363686 0.000536259510881926 yes 29 0.000473297764738404 3 2991449
SGTC_644 1498-1197 63.3 µM 3.2940524848836 0.000558670282680151 yes 30 0.000493770285210948 12 6741615
SGTC_2802 7925815 54.55 µM 3.2835579924591 0.000579177555425499 yes 31 0.000512527761920226 15 1262923
SGTC_2779 methotrexate 400 µM 3.22700954641938 0.0007021650834054 yes 32 0.000625456433110828 25 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_653 0203-0016 55.2 µM 3.21374236705044 0.000734311624476975 yes 33 0.000655085862040477 8 295302
SGTC_2843 9000894 45.46 µM 3.1511641551835 0.000905029863286776 yes 34 0.000813105320288632 6 2242070
SGTC_3007 9078383 71.4286 µM 3.1421696048101 0.000932367384536677 yes 35 0.00083850431016888 12 6496995
SGTC_1222 0366-0074 1.18 µM 3.10276107629135 0.00106131649034496 no 36 0.000958621780396421 11 286520
SGTC_1148 3909-7663 27.7 µM 3.10128864774732 0.00106643719514316 no 37 0.000963401832806028 9 4084526
SGTC_1308 1187-1617 41.4 µM 3.05800849738073 0.00122745655361337 no 38 0.00111406628910559 26 2882570
SGTC_152 4469-0003 551.229 µM 3.01173207181634 0.00142399238831495 no 39 0.00129880879777939 34 697280
SGTC_617 3770-0098 35 µM 2.93143526780769 0.00183432573879159 no 40 0.00168699837146017 32 5962639
SGTC_1135 dihydrocapsaicin 536.708 nM 2.88206087901299 0.00213731869048669 no 41 0.00197541695972326 16 107982 A Capsaicinoid.
SGTC_1452 4194-0072 190 µM 2.81151655513453 0.00264918176499239 no 42 0.00246542765953429 16 1343545
SGTC_650 1328-0195 38 µM 2.79745651482055 0.00276355870114838 no 43 0.00257533500347527 16 2780821
SGTC_806 3966-4455 5.86 µM 2.78008832654478 0.00291099018792467 no 44 0.00271720574773345 23 714982
SGTC_2048 5246248 200 µM 2.77052695092181 0.00299514495819537 no 45 0.00279828342237084 9 677046
SGTC_309 k408-0051 1.48 µM 2.76582242902367 0.00303735127652263 no 46 0.00283897216601209 54 3640463
SGTC_245 methotrexate 289.6 µM 2.73867066844081 0.00329157927738926 no 47 0.00308440665164947 29 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1597 7-benzyloxygramine 47.5 µM 2.73392367649396 0.00333794187654146 no 48 0.00312922747650174 77 260807
SGTC_1997 st073024 93.8 µM 2.70659396788377 0.00361646592864115 no 49 0.00339886706470577 11 686268
SGTC_2174 5790901 200 µM 2.70111545641183 0.00367474628039512 no 50 0.0034553671936668 31 786020
SGTC_1251 0490-5699 265 µM 2.68623784914386 0.00383728823389387 no 51 0.00361308141979449 25 3883818
SGTC_893 0958-0369 48.9 µM 2.68235469454063 0.0038807597142879 no 52 0.00365529513919249 18 6819948
SGTC_2254 7938975 95.19 µM 2.67878634447337 0.00392109551518032 no 53 0.00369447622773907 27 2969277
SGTC_2915 7971052 15.16 µM 2.67567592231326 0.0039565609400117 no 54 0.00372893606198267 12 5741558
SGTC_451 chloral hydrate 100 µM 2.64605160941511 0.00430901297667465 no 55 0.0040718695354485 49 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_394 menadione 8.33 µM 2.63768734649003 0.00441348095427638 no 56 0.00417367514672303 25 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_565 1418-0001 44.5 µM 2.63061895012477 0.00450352165330331 no 57 0.0042614768882977 21 2862145
SGTC_904 1141-0088 396 µM 2.61059065053293 0.00476762561437216 no 58 0.00451930066222438 20 1378119
SGTC_1912 st060209 90.8 µM 2.60543030821661 0.00483787253936333 no 59 0.00458794693039013 34 688787
SGTC_1141 3253-0389 52.6 µM 2.56884913255297 0.00536285992328011 no 60 0.0051018434710299 22 5402031
SGTC_1041 0206-0046 107 µM 2.56875216177767 0.0053643163964222 no 61 0.00510327122524964 22 50494
SGTC_2296 7971656 126.45 µM 2.55471498442874 0.00557889740147866 no 62 0.00531373894656535 24 666570
SGTC_527 4476-4215 268 µM 2.55147270590076 0.0056295317984734 no 63 0.00536343628622916 18 4418754
SGTC_2063 5246145 200 µM 2.54695057404745 0.00570083498766327 no 64 0.00543344116734061 31 711240
SGTC_129 0088-0017 176.636 µM 2.54327300436243 0.00575941135934005 no 65 0.00549096934908759 17 182446
SGTC_118 0083-0097 135.343 µM 2.54152092380662 0.0057875059086912 no 66 0.00551856698887029 57 5207356
SGTC_887 0885-0007 9.62 µM 2.53527488519235 0.00588865295061392 no 67 0.00561795595220204 46 5719458
SGTC_15 0266-0086 27.098 µM 2.5264251566013 0.0060346475822277 no 68 0.00576149688791787 38 1712902 YIL048W NEO1
SGTC_2589 lobaric acid 100 µM 2.50409557940566 0.00641737313822892 no 69 0.00613824324689913 18 73157 A novel microtubule depolymerizer.
SGTC_2107 5363541 170.161 µM 2.4929342565278 0.00661660863839574 no 70 0.00633461509527559 34 244052
SGTC_1871 st057448 67.3 µM 2.4854962278976 0.00675239939967569 no 71 0.00646854791213518 36 691747
SGTC_1138 3761-0006 1.03 µM 2.47860905996772 0.00688032306174391 no 72 0.00659478909679517 7 12061087
SGTC_2896 9052656 71.43 µM 2.478369079769 0.00688481883383678 no 73 0.00659922691943169 63 6469436
SGTC_1521 st012942 49.4 µM 2.47539412697786 0.00694076718651854 no 74 0.00665446074629798 24 24207259
SGTC_1700 st030840 7.9285 µM 2.4722225230136 0.00700085558556477 no 75 0.00671379534094688 41 5499307
SGTC_655 k060-0012 42 µM 2.44117759167088 0.00761370034050341 no 76 0.00731972681708621 38 5994525
SGTC_1996 st072960 66.8 µM 2.43532836648292 0.00773431491734251 no 77 0.00743914054950628 23 1719405
SGTC_1001 4048-4355 44.4 µM 2.42990716674836 0.00784760163430558 no 78 0.00755134529786226 41 21824233
SGTC_1079 idarubicin 2.36 µM 2.41831427199685 0.00809476764343073 no 79 0.00779630165264668 33 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_715 0868-0130 184 µM 2.41476266685347 0.00817184633542716 no 80 0.00787273276604116 13 2876258
SGTC_1735 st034310 56.75 µM 2.39279561219472 0.00866306990659251 no 81 0.00836027628303095 37 871153
SGTC_2096 5468907 200 µM 2.3845969590899 0.00885293658880722 no 82 0.00854892088620521 29 759785
SGTC_2570 licareol 100 µM 2.37668663699575 0.00903957283004218 no 83 0.00873446074483684 35 443158
SGTC_844 0330-0132 15.3 µM 2.37437136554972 0.0090948472755315 no 84 0.0087894300917416 21 2828079
SGTC_874 0599-0792 117 µM 2.37106635291483 0.00917426334723627 no 85 0.00886842329046978 40 765305
SGTC_2679 rapamycin 1 nM 2.37027932052825 0.00919326418077553 no 86 0.00888732563826193 95 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1456 k015-0012 13 µM 2.3468623178795 0.00977458769624502 no 87 0.0094661246030277 41 2989616
SGTC_910 3454-3003 490 µM 2.32356545457494 0.0103845386968857 no 88 0.010074397867745 41 820824
SGTC_740 k014-0057 261 µM 2.30739935433871 0.0108270558307866 no 89 0.010516283601106 40 4012779
SGTC_913 3487-1245 167 µM 2.30566939017745 0.0108753688618366 no 90 0.0105645563681121 43 4016153
SGTC_2119 5528445 120.635 µM 2.30418259283945 0.0109170407381055 no 91 0.0106061979652493 35 791935
SGTC_2002 4023503 131 µM 2.29159532867089 0.0112754382501226 no 92 0.0109645026455776 50 4736863 YCR052W RSC6
SGTC_518 1021-0119 62.6 µM 2.28792019711864 0.0113819907271798 no 93 0.0110710844445503 42 1097762
SGTC_2176 5809774 33.9695 µM 2.2862226869396 0.0114315010211487 no 94 0.0111206170892051 11 2870539
SGTC_1540 guanosine 70.6 µM 2.27012295310851 0.0119104497568745 no 95 0.0116000620189557 26 6802 Guanosine is a purine nucleoside
SGTC_399 oxolinic acid 75 µM 2.24932124236135 0.0125549809394926 no 96 0.0122460326435886 29 4628 A DNA gyrase inhibitor.
SGTC_1324 1418-0026 34.4 µM 2.22896578548143 0.0132146976525104 no 97 0.0129080906847625 34 1372513
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.22792533249769 0.0132492085595815 no 98 0.0129427472887795 26 688751
SGTC_732 3970-1727 52.7 µM 2.21336787284431 0.0137402931819311 no 99 0.0134361468646062 35 1275699
SGTC_3004 9076122 71.4286 µM 2.19973695356424 0.0142142771133107 no 100 0.0139127816791896 37 44782551
SGTC_798 1287-0182 476 µM 2.19420485709079 0.0144106240145524 no 101 0.0141103427782482 37 1649755
SGTC_940 3232-1287 54.8 µM 2.19412498395727 0.0144134759128406 no 102 0.0141132128044624 26 1585493 YIL048W NEO1
SGTC_869 0564-0080 44.1 µM 2.19338353502845 0.0144399728072735 no 103 0.0141398787942389 28 6843321
SGTC_2977 9011197 71.43 µM 2.17357130326921 0.0151636900023931 no 104 0.0148686727522891 42 2704722
SGTC_273 hydroxyurea 18.1 mM 2.17019310559669 0.0152901515264097 no 105 0.014996110079518 69 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_696 1560-0013 611 µM 2.16922040274398 0.0153267318143222 no 106 0.0150329774376494 49 1650269
SGTC_1413 3910-0535 34.4 µM 2.16727665287467 0.0154000553080977 no 107 0.0151068828097117 31 2876951
SGTC_831 k061-1017 217 µM 2.16499349983568 0.015486566469858 no 108 0.0151940915329164 60 1240153
SGTC_524 r073-0010 27.8 µM 2.15864100777958 0.0157294675465231 no 109 0.0154390143647082 59 2772106
SGTC_2909 7941780 10.49 µM 2.14671004265405 0.0161945138740157 no 110 0.0159081863806215 39 1243215
SGTC_1642 st009582 77.7 µM 2.14250891511867 0.0163610463854879 no 111 0.0160762760249553 53 6739311
SGTC_1644 st010134 20.9 µM 2.13735403539812 0.0165673873226747 no 112 0.0162846034777303 28 3818134
SGTC_1248 0469-0687 58.6 µM 2.13225578463152 0.0167736481143988 no 113 0.016492912381126 50 4017482
SGTC_300 r073-0011 5.04 µM 2.13036794078311 0.0168505802461024 no 114 0.0165706242113302 39 2735780
SGTC_1877 wortmannin 25 µM 2.12817006173466 0.01694052669879 no 115 0.016661493041836 46 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.12256452207138 0.0171717895282925 no 116 0.0168951802776608 60 1273210
SGTC_832 4083-0019 164 µM 2.1206651283133 0.0172507606356711 no 117 0.0169749965421553 86 1990758
SGTC_1304 1165-0502 251 µM 2.11041826829973 0.0176821666119331 no 118 0.0174111721491659 50 767425
SGTC_1694 st024011 44.9 µM 2.07876120014232 0.019073576468737 no 119 0.0188196523727845 44 2787533
SGTC_648 0375-0473 33.3 µM 2.04963075668258 0.0204351276326283 no 120 0.0202002383524623 53 1713139
SGTC_938 3126-1755 342 µM 2.04846400315687 0.0204913346061486 no 121 0.0202572778788145 26 1777771
SGTC_364 0083-0097 67.7 µM 2.02084757139646 0.0218604655403389 no 122 0.0216477732975135 54 5207356
SGTC_670 4204-0025 119 µM 2.0191183702309 0.0219487048466511 no 123 0.0217374589742089 36 719039
SGTC_816 0325-0417 81.3 µM 2.01883828183153 0.0219630257240841 no 124 0.0217520153631793 51 68101
SGTC_3017 9080681 49.47 µM 2.01616717306077 0.0220999959091408 no 125 0.0218912489059518 40 16451914
SGTC_791 1348-1292 225 µM 2.00899184134021 0.0224715095682379 no 126 0.0222689994897871 39 5437054
SGTC_317 4495-0002 170 µM 2.00317276412456 0.0227766558984629 no 127 0.0225793739812429 42 15991618
SGTC_3297 9117502 71.43 µM 2.00311502991873 0.0227797008275049 no 128 0.0225824715531565 22 7453720
SGTC_939 1165-0479 45.3 µM 2.0020154844254 0.0228377568794522 no 129 0.0226415330960026 44 1377347
SGTC_223 busulfan 5 mM 2.00055784813534 0.022914912276716 no 130 0.0227200299851927 46 2478 A DNA alkylator.
SGTC_401 neomycin 50 µM 1.99301983645115 0.0233174257616317 no 131 0.0231296375009562 37 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_882 0843-0131 351 µM 1.98986491149336 0.0234876497402088 no 132 0.0233029092770516 74 5425421
SGTC_1686 st019653 115.5 µM 1.98798065136521 0.0235898127688218 no 133 0.0234069149563918 49 97252
SGTC_2076 5212012 200 µM 1.97928695448126 0.0240660308239516 no 134 0.0238918537687476 40 604802
SGTC_412 gemfibrozil 100 µM 1.97274596942456 0.0244296310144594 no 135 0.0242622558676306 53 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_567 1080-0542 68.4 µM 1.96613201397044 0.0248019653270344 no 136 0.0246416816083795 47 5950415
SGTC_988 1497-1057 103 µM 1.96465455025415 0.0248857867453748 no 137 0.0247271168381204 52 3533044
SGTC_1560 lithocholic acid 53.1 µM 1.96016026360154 0.0251422242349273 no 138 0.0249885306628919 32 9903 A bile acid which acts as a detergent.
SGTC_1946 st076057 65.1 µM 1.95513092232049 0.0254318133338584 no 139 0.025283809645903 35 953009
SGTC_1008 4106-0037 6 µM 1.94793371084383 0.0258510836277076 no 140 0.0257114477437583 52 2905394
SGTC_753 1322-0200 289 µM 1.94524414477717 0.0260092405528773 no 141 0.0258728005364477 31 5403907
SGTC_2402 5553605 200 µM 1.94503246344075 0.0260217225211397 no 142 0.0258855356366248 57 6758546
SGTC_351 caspofungin 25 nM 1.93606674013882 0.026555012665863 no 143 0.0264297637119133 91 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1513 0337-0559 19 µM 1.93458897541846 0.0266437821610841 no 144 0.0265203769808932 52 775073
SGTC_111 0083-0039 52.457 µM 1.93093309911032 0.0268644566727022 no 145 0.0267456631543468 28 759313
SGTC_891 0929-0073 133 µM 1.92354430402105 0.0273151162908005 no 146 0.0272058640340532 58 5603632
SGTC_3016 9080866 49.47 µM 1.91740616557971 0.0276942743503039 no 147 0.0275931757796429 53 17066299
SGTC_3306 9127676 59.7925 µM 1.9148981224913 0.0278504555498765 no 148 0.0277527486570417 36 41905287
SGTC_2415 st077333 57.7 µM 1.91334669566069 0.0279474330412831 no 149 0.0278518417516484 89 2766255
SGTC_2906 7926292 26.41 µM 1.9123289914353 0.0280112009293237 no 150 0.0279170047555963 48 2966319
SGTC_2772 vinpocetine 57.06 µM 1.9032376793036 0.0285862431377173 no 151 0.0285047693132267 51 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1145 3546-0597 10.2 µM 1.89745885326967 0.0289568437576194 no 152 0.0288837022215229 52 875334
SGTC_2920 7982904 15.77 µM 1.88192135242557 0.029973119836533 no 153 0.0299233474160139 68 6456808
SGTC_1809 st050081 57.6 µM 1.86944961327205 0.0308101152765545 no 154 0.0307801437734059 51 5036894
SGTC_2629 bisabolol 100 µM 1.86804860385893 0.0309053362419696 no 155 0.0308776482528939 75 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_598 3937-0236 20.2 µM 1.86767348463171 0.0309308728830772 no 156 0.0309037983513551 60 1379313
SGTC_2125 5246583 200 µM 1.85502945502983 0.0318018962543719 no 157 0.0317960102435205 70 835267
SGTC_634 1611-4317 11.2 µM 1.85388313694797 0.0318818559869017 no 158 0.0318779404660766 68 2843522
SGTC_2682 pyrogallin 40.03 µM 1.85105676641153 0.0320797149737462 no 159 0.0320806934655437 62 822798 An ATP competetive kinase inhibitor.
SGTC_488 nitrendipine 139 µM 1.85093420111867 0.0320883179941442 no 160 0.0320895098619763 43 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_529 4076-0302 30.3 µM 1.84389053880843 0.032585931492817 no 161 0.0325995471061741 46 5816522
SGTC_812 4251-0442 148 µM 1.83577135395065 0.0331674062021508 no 162 0.0331957399052463 68 5723007
SGTC_1397 3532-0190 20.1 µM 1.82363587472865 0.0340524301082228 no 163 0.0341035696211873 43 5322280
SGTC_2109 5483026 200 µM 1.82084229352785 0.0342588882533077 no 164 0.0343154166003716 121 759335
SGTC_930 2810-3379 265 µM 1.8205638412359 0.0342795233915568 no 165 0.0343365917516686 72 1015764
SGTC_1151 3909-8316 15.3 µM 1.81325120670744 0.0348251046722425 no 166 0.0348965425989065 63 800431
SGTC_2188 6126565 140.678 µM 1.81031921172039 0.0350458480049 no 167 0.0351231497294181 56 874518
SGTC_3292 9120825 59.784 µM 1.80677558663154 0.0353141707709905 no 168 0.0353986383507803 75 24824900
SGTC_1508 1080-0625 72.9 µM 1.8067508315833 0.0353160511295366 no 169 0.0354005690732267 54 767111
SGTC_1385 3091-4834 14.1 µM 1.7957390209035 0.0361606721856158 no 170 0.0362680164409077 57 4072814
SGTC_1186 1319-0216 26 µM 1.79561364809909 0.0361703828536752 no 171 0.0362779918847078 66 4565136
SGTC_433 pimozide 108 µM 1.79270355343351 0.0363963829359413 no 172 0.0365101690208538 49 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1654 st012436 41.8 µM 1.78384998757566 0.0370910727795101 no 173 0.0372240222073412 34 4323132
SGTC_2753 fluvastatin 17.09 µM 1.7828686786048 0.0371687333352925 no 174 0.0373038413743579 82 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_606 k015-0008 38.6 µM 1.77765798078359 0.0375833356040482 no 175 0.0377300224107447 67 1970475
SGTC_484 loperamide 105 µM 1.77528110696914 0.0377737076556661 no 176 0.0379257416802393 24 3955 An opioid-receptor agonist.
SGTC_1007 4101-0031 70 µM 1.77429600952107 0.0378528378696224 no 177 0.0380071001471934 77 1146276
SGTC_2398 5228213 48.84 µM 1.77377908744677 0.0378944149072686 no 178 0.0380498492845093 95 80771 YMR134W ERG29
SGTC_389 tpck 16.7 µM 1.77161394097369 0.0380689669085478 no 179 0.0382293319644477 55 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_404 fumagillin 50 µM 1.77087121915171 0.0381289952858527 no 180 0.0382910596753567 67 12015870 A methionine aminopeptidase binder.
SGTC_1913 st060213 96.1 µM 1.77009151243229 0.0381920959029971 no 181 0.0383559486181229 64 688959
SGTC_3125 9127534 49.47 µM 1.75667408087248 0.0392913547181925 no 182 0.0394866889406121 47 1639235
SGTC_2717 st081029 62.2815 µM 1.75649794950755 0.0393059541724654 no 183 0.0395017106186963 55 5292846
SGTC_179 1273-0063 6.77 µM 1.75454371891903 0.0394682359003588 no 184 0.0396686927707019 44 3108139
SGTC_626 0214-0009 33 µM 1.7537892033375 0.0395310374695203 no 185 0.039733316874102 72 3437874
SGTC_1119 parthenolide 318.541 nM 1.75278690110567 0.0396145890614047 no 186 0.0398192962043419 75 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2341 7987486 176.74 µM 1.75067932505269 0.0397907444168815 no 187 0.0400005813489029 63 1258686
SGTC_3065 9113888 49.47 µM 1.7465617013567 0.0401367408312234 no 188 0.0403566977240689 70 16648368
SGTC_140 0062-0056 502.533 µM 1.72996330236986 0.0415563369667791 no 189 0.0418184160132367 60 3758964
SGTC_2495 cafestol 54.53 µM 1.72183201823663 0.0422664735659362 no 190 0.0425499763429835 96 16667697 An anti-infammatory.
SGTC_155 k072-0202 43.6 µM 1.718928983098 0.0425223729770303 no 191 0.0428136519772399 77 5857737
SGTC_537 1334-0398 209 µM 1.71877973772623 0.0425355625836744 no 192 0.0428272431844417 83 5846986
SGTC_2372 9071633 200 µM 1.7178487616022 0.0426179125938698 no 193 0.0429121023696766 65 21321366
SGTC_2711 st079103 59.1 µM 1.71737616295819 0.0426597658712229 no 194 0.0429552320627881 53 54693780
SGTC_2620 irigenin 100 µM 1.70610579302332 0.0436677513968465 no 195 0.0439941920972723 96 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2384 9036245 200 µM 1.70519664584777 0.0437498933142681 no 196 0.0440788776893409 51 6462766
SGTC_213 1246-0773 967 nM 1.70191421034735 0.0440475011313558 no 197 0.0443857257562001 52 6251622
SGTC_2916 7875993 68.79 µM 1.69773715067325 0.044428579709213 no 198 0.0447786913337371 76 1299250
SGTC_2309 7664088 163.95 µM 1.6951466686982 0.0446662443470369 no 199 0.0450238004891298 78 704922
SGTC_1750 st081859 2.357 µM 1.69221686310405 0.0449362731301216 no 200 0.0453023162146155 108 5291695
SGTC_3224 9130643 49.47 µM 1.68661385188217 0.0454563397010121 no 201 0.0458388133472337 77 17644395
SGTC_1900 st060200 72.8 µM 1.67381921748591 0.0466620787826301 no 202 0.047083067150746 81 688945
SGTC_2463 5473429 200 µM 1.67167341665986 0.0468667848477801 no 203 0.0472943694483641 60 5399405
SGTC_1691 st019933 84.6 µM 1.66804962709432 0.0472141235204242 no 204 0.0476529377967257 77 6176082
SGTC_871 0574-0004 149 µM 1.66796465504442 0.047222292746362 no 205 0.047661371702083 107 9551173
SGTC_1624 st003710 6.25 µM 1.6674708791443 0.0472697868606006 no 206 0.0477104051158994 69 24207033
SGTC_2311 7694451 200 µM 1.66725013835132 0.04729103131794 no 207 0.0477323383948025 111 2163142
SGTC_1427 4048-4900 550 nM 1.66518185341696 0.0474904584151913 no 208 0.0479382401049343 79 24132586
SGTC_2127 5253358 187.912 µM 1.66342282327467 0.0476605963754683 no 209 0.0481139138298572 77 20612
SGTC_1553 gossypol 38.6 µM 1.64633521916474 0.0493388749790947 no 210 0.0498473811359766 51 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_564 3555-0129 330 µM 1.64629124997706 0.0493432535464864 no 211 0.0498519050472345 68 563260
SGTC_3342 9147791 14.508 µM 1.64047278125222 0.049925414137524 no 212 0.0504534516690129 72 1838168
SGTC_2861 9024595 19.48 µM 1.63934766559199 0.0500386158964305 no 213 0.0505704371582988 34 16482810
SGTC_2934 9036370 36.88 µM 1.6385133212729 0.0501226942362019 no 214 0.050657328735669 72 6462800
SGTC_2355 9061122 103.12 µM 1.637831149208 0.0501915215683744 no 215 0.0507284608763681 77 5302957
SGTC_2085 5307070 144.047 µM 1.63675939494724 0.0502998076986951 no 216 0.0508403765556549 95 2840351
SGTC_1430 4049-0248 69.1 µM 1.63590641760306 0.0503861224026979 no 217 0.0509295873294316 76 22774488
SGTC_1630 st005209 31.3 µM 1.63506263769491 0.0504716224818459 no 218 0.0510179587291455 74 3367314
SGTC_506 n9-isopropylolomoucine 153 µM 1.63320334285896 0.0506604325113371 no 219 0.0512131185792354 50 6610355
SGTC_1257 0669-0121 16 µM 1.63158740300739 0.0508249865619718 no 220 0.0513832168509533 90 4307855
SGTC_1800 st050079 29.0735 µM 1.6268224737715 0.0513126864193672 no 221 0.0518874035486102 108 3645560
SGTC_1451 4152-0210 104 µM 1.62287188076302 0.0517198538896618 no 222 0.0523083978652781 77 659563
SGTC_3284 9108171 64.8615 µM 1.62265688678679 0.0517420856980036 no 223 0.052331386256465 81 8687505
SGTC_1170 0310-0127 64.8 µM 1.61959743538413 0.0520592772096959 no 224 0.052659390440414 92 774975
SGTC_571 k831-0106 44.2 µM 1.61815652747331 0.0522091988122189 no 225 0.052814434441409 91 4783639
SGTC_2860 9025725 38.96 µM 1.61648525212277 0.052383518652658 no 226 0.0529947197279525 79 40546248
SGTC_3119 9125183 49.47 µM 1.61512419708577 0.0525258225636565 no 227 0.0531419009422045 52 22695334
SGTC_1449 4112-4002 201 µM 1.61207603083708 0.0528456339932513 no 228 0.0534726979383772 77 2059539
SGTC_3202 9113761 49.47 µM 1.598815270561 0.054254957796205 no 229 0.0549308274751043 101 4798415
SGTC_1382 3002-2117 298 µM 1.59846232599386 0.0542928703349228 no 230 0.0549700617012647 84 1497314
SGTC_2650 prasterone 100 µM 1.5974494377848 0.0544017889855309 no 231 0.0550827799323899 51 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.59679628674175 0.0544721157266026 no 232 0.0551555619697105 107 4114 Related to psoralen; DNA damaging agent.
SGTC_588 3970-1144 52.9 µM 1.59040965176247 0.0551635789957891 no 233 0.0558712480767935 56 1888707
SGTC_2476 5806916 10.51 µM 1.58898635305262 0.0553186163926986 no 234 0.0560317368863738 78 2870194
SGTC_1938 st074717 56.4 µM 1.58173235561013 0.0561141341419285 no 235 0.0568553415280347 70 17250979
SGTC_1398 3558-0053 112 µM 1.58049843469332 0.0562503468679703 no 236 0.0569963825425404 56 4532369
SGTC_2196 6573537 42.6665 µM 1.58011172911313 0.0562930889661457 no 237 0.0570406408471651 88 2903087
SGTC_839 0122-0028 230 µM 1.57748514459867 0.0565840800700606 no 238 0.0573419688136469 144 759448
SGTC_312 4092-0653 6.84 µM 1.5750975631828 0.056849619889989 no 239 0.0576169632252259 116 1148278
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.57505211751168 0.0568546837259329 no 240 0.0576222075613561 69 4174840
SGTC_739 1486-1183 203 µM 1.57224264932856 0.0571684222807606 no 241 0.0579471439365101 72 4346692
SGTC_3096 9117468 49.47 µM 1.57201628253063 0.0571937602877374 no 242 0.0579733875489666 65 41316311
SGTC_2316 5844804 197.44 µM 1.57179802606217 0.0572181988465663 no 243 0.0579986997428421 112 776813
SGTC_2751 anetholtrithion 17.25 µM 1.56929576420842 0.0574989690765318 no 244 0.058289519422576 82 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2856 9022925 19.48 µM 1.56534411251052 0.0579445762458872 no 245 0.0587511225275556 87 4944862
SGTC_2863 9028737 58.44 µM 1.56387391297838 0.0581110541057077 no 246 0.0589235909777871 63 6460917
SGTC_1652 st011932 78 µM 1.56231363451528 0.0582881428755567 no 247 0.0591070607870414 101 1551076
SGTC_562 3772-2733 112 µM 1.5583679826925 0.0587378587506345 no 248 0.0595730209415526 83 2876874 YIL048W NEO1
SGTC_75 0159-0059 199.013 µM 1.55771169683268 0.0588129240894838 no 249 0.0596508032398687 103 5377270
SGTC_1882 5615643 20 µM 1.55340631535457 0.0593072379059823 no 250 0.060163047549439 79 2253075
SGTC_2707 st078556 66.6 µM 1.54835384890302 0.0598914747087708 no 251 0.0607685631068552 70 17250899
SGTC_74 000s-0487 160.283 µM 1.54708289655071 0.0600391472947246 no 252 0.0609216288101049 74 677548
SGTC_1616 st002734 56.1 µM 1.54543813326957 0.0602306762196912 no 253 0.061120161264385 93 4026101
SGTC_1489 4065-0444 182 µM 1.54485997354767 0.0602981150927753 no 254 0.0611900684787326 78 2877968
SGTC_431 k089-0097 107 µM 1.54048273996879 0.0608106124404577 no 255 0.0617213634198577 105 5499420
SGTC_2829 7992743 58.44 µM 1.53719644827593 0.0611976133768629 no 256 0.062122604922577 74 16462845
SGTC_2121 5257820 149.641 µM 1.53566372873795 0.0613787666915666 no 257 0.0623104376471597 71 791256
SGTC_463 ikarugamyin 104 µM 1.52147147522257 0.0630761180079763 no 258 0.0640707821235297 38 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2191 5911152 200 µM 1.52116986025457 0.0631125830099701 no 259 0.0641086084167359 85 2875902
SGTC_2223 6903751 107.57 µM 1.51919679115938 0.0633515305652658 no 260 0.0643564843949774 84 5598863
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.51417512540241 0.0639628540786816 no 261 0.0649907143963207 121 368090
SGTC_320 4092-0846 5.34 µM 1.51331279372542 0.0640682918935968 no 262 0.0651001122304414 106 1359356
SGTC_1086 cerivastatin 2.18 µM 1.5091550824763 0.0645785552297174 no 263 0.0656295779411187 84 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2526 patulin 37.61 µM 1.50690018212691 0.0648566095611726 no 264 0.0659181223853403 115 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1491 4138-0063 26.5 µM 1.50276490500273 0.0653689496018986 no 265 0.0664498394423145 86 23883227
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.50101939073353 0.0655861500119047 no 266 0.0666752731452995 114 5393153
SGTC_2770 toltrazuril 17.5 µM 1.49995358250634 0.0657190471374934 no 267 0.0668132133603286 76 68591 Kills coccidiodes.
SGTC_3289 9119912 71.43 µM 1.49970620079933 0.0657499233398793 no 268 0.0668452618203937 90 17014829
SGTC_1716 st033144 30.6155 µM 1.49639115592111 0.0661647664568333 no 269 0.0672758764484003 97 674617
SGTC_3194 9111903 49.47 µM 1.49595087581622 0.0662200150773444 no 270 0.0673332285076033 96 17087251
SGTC_2846 9008642 19.48 µM 1.49515546338001 0.0663199181148513 no 271 0.0674369368568713 109 2992898
SGTC_1322 1348-1070 12 µM 1.49229838006351 0.0666797277993515 no 272 0.0678104706178245 92 6758089
SGTC_986 1493-0483 84 µM 1.49205443099935 0.0667105196394483 no 273 0.0678424383078901 94 40079
SGTC_2457 5731572 11.68 µM 1.48866725965369 0.067139194506926 no 274 0.0682875052785352 109 2865357
SGTC_973 1325-0077 65.9 µM 1.4881884153943 0.0671999677180847 no 275 0.0683506057456445 85 2835149
SGTC_846 0335-0850 148 µM 1.48575584657847 0.067509357792887 no 276 0.0686718564439945 87 6819598
SGTC_457 grayanotoxin iii 135 µM 1.47621154435326 0.0687339060811427 no 277 0.0699435556882377 119 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_865 0488-0499 301 µM 1.47462702837993 0.0689388493371006 no 278 0.0701564221043765 89 9634651
SGTC_2524 avocatin b 10.57 µM 1.474171651692 0.0689978353742768 no 279 0.0702176902298655 57 6710748
SGTC_528 3492-0019 172 µM 1.4720552876011 0.0692724837241176 no 280 0.0705029741461127 124 2869262
SGTC_1499 4480-0877 67.3 µM 1.47196894718322 0.0692837062924102 no 281 0.0705146316427388 82 2861909
SGTC_156 3474-0145 5.642 µM 1.46376838536808 0.0703560165708564 no 282 0.0716286216344693 92 2265471
SGTC_2211 7117706 200 µM 1.45844868368659 0.071058418640977 no 283 0.0723584549958036 85 822771
SGTC_2022 5136654 200 µM 1.45620720976742 0.071355985718284 no 284 0.0726676735302019 122 1713771
SGTC_1066 ketoconazole 628 nM 1.45564487615736 0.0714307882371957 no 285 0.0727454078181413 104 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1902 st060212 70.5 µM 1.45440702279417 0.0715956615097929 no 286 0.072916747029028 105 688944
SGTC_2497 7-hydroxyflavone 100 µM 1.45056642600137 0.0721090602354757 no 287 0.0734503149394155 116 5281894
SGTC_1212 0520-0165 585 µM 1.4471889786862 0.0725628745719172 no 288 0.0739220012469876 110 5403258
SGTC_1923 st058458 19.1 µM 1.44387517163947 0.0730102608232174 no 289 0.0743870459087518 117 3534982
SGTC_2146 5545642 200 µM 1.44000974413452 0.0735347835713267 no 290 0.0749323211390665 108 825326
SGTC_1490 4089-0339 670 nM 1.43999702225304 0.0735365146235235 no 291 0.0749341207672121 104 742542
SGTC_285 1486-1325 46 µM 1.43748905494047 0.0738783798610409 no 292 0.0752895402914131 114 22310230
SGTC_1590 st077108 57.8 µM 1.4360182799864 0.07407942788032 no 293 0.0754985698629856 91 5489485
SGTC_2308 7584454 197.62 µM 1.43409630203755 0.0743427828533072 no 294 0.075772391526679 117 893577
SGTC_385 1494-0393 12.4 µM 1.43013929924519 0.0748872330666716 no 295 0.0763385214520907 109 3090647
SGTC_2347 9049783 174.81 µM 1.42420665042434 0.0757092071923662 no 296 0.0771933301604055 106 6467988 YPL169C MEX67
SGTC_2421 5690543 90.72 µM 1.42298683960528 0.0758790617806099 no 297 0.0773699851719998 115 3397993
SGTC_1903 st060211 78.3 µM 1.41495016632913 0.0770054040886106 no 298 0.0785415538648875 109 688960
SGTC_441 propafenone 146 µM 1.41429586281686 0.0770976613821194 no 299 0.0786375255957393 116 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2804 7954240 19.48 µM 1.41341291827419 0.0772222903529126 no 300 0.0787671747220934 118 828705
SGTC_1832 st054113 55 µM 1.41138377539407 0.0775092869854499 no 301 0.0790657421656085 88 1251267
SGTC_3218 9131285 49.47 µM 1.40384229146155 0.0785830366353611 no 302 0.0801829086300596 111 17156417
SGTC_2944 9067346 25.62 µM 1.40141018613425 0.0789317110491019 no 303 0.0805457239968369 127 6473075
SGTC_1803 st050068 52.4 µM 1.39832798286869 0.0793752676778681 no 304 0.0810072992422501 114 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_797 k781-0471 270 µM 1.39729346347538 0.0795245663965275 no 305 0.0811626703259427 114 23738129
SGTC_88 0180-0332 8.668 µM 1.39422042717726 0.0799693108910841 no 306 0.0816255256307675 123 3101745
SGTC_1270 0831-1170 17.3 µM 1.39074182721808 0.0804750169984477 no 307 0.082151864517518 117 6764716
SGTC_2747 doxorubicin 7.63 µM 1.38966469458847 0.0806320954397745 no 308 0.082315360231435 69 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1048 3161-0300 24.5 µM 1.38783569176913 0.0808993495151278 no 309 0.0825935418588976 90 2165101
SGTC_409 arachidonic acid 100 µM 1.38709828089945 0.0810072890198938 no 310 0.0827058980828432 108 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1466 k213-0079 57.5 µM 1.38656092434768 0.0810860137463708 no 311 0.0827878452837493 142 3657981
SGTC_2218 6965428 192.983 µM 1.38163494637623 0.0818103803544754 no 312 0.0835419090628377 94 675684
SGTC_2975 9084847 53.72 µM 1.37779637834361 0.0823782159179871 no 313 0.0841330822615763 112 27211724
SGTC_1602 st001878 87.6 µM 1.37642899284192 0.0825812071591468 no 314 0.0843444284864362 134 595405 YLR310C CDC25
SGTC_1114 scopoletin 1.73284 µM 1.37478591639324 0.0828256230480912 no 315 0.0845989128207798 101 5280460 A coumarin with genotoxic properties.
SGTC_3168 9103419 49.47 µM 1.37476087335763 0.0828293525321319 no 316 0.0846027960081063 85 16649256
SGTC_2608 thymoquinone 42.66 µM 1.37397603443982 0.0829462971379371 no 317 0.0847245613374685 102 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3152 9099253 49.47 µM 1.37181311488477 0.0832692248497436 no 318 0.0850608117361522 152 25236131
SGTC_2045 5106652 78.05 µM 1.36994695988748 0.0835486038722957 no 319 0.0853517296073631 96 673349
SGTC_1359 1582-0056 520 nM 1.36684377503759 0.0840147352191606 no 320 0.085837139226514 101 3661189
SGTC_2262 9014885 67.46 µM 1.36535746694618 0.0842386848909074 no 321 0.08607036258776 91 6457424
SGTC_3215 9129942 49.47 µM 1.36415521849835 0.0844201613849656 no 322 0.0862593594419351 115 17682944
SGTC_1656 st012921 11 µM 1.36400007566097 0.0844436011738561 no 323 0.0862837709283953 105 6732821
SGTC_2948 9070189 9.45 µM 1.36381530204591 0.0844715241056839 no 324 0.0863128515128181 97 6473636 YDL196W YDL196W
SGTC_1055 3448-0672 86 µM 1.3628655969965 0.0846151525521104 no 325 0.0864624364495981 118 748378
SGTC_1435 4092-0789 56.7 µM 1.35967538641112 0.0850989645711081 no 326 0.0869663352023904 137 2248285
SGTC_2625 euphol 100 µM 1.35212377383 0.0862524635136824 no 327 0.0881678616051054 136 6708538 A triterpene alcohol.
SGTC_1252 0493-0875 34.8 µM 1.35154592169291 0.0863412090038797 no 328 0.0882603100159439 100 3960963
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.34639335516456 0.0871355519037786 no 329 0.0890878463838441 122 551469
SGTC_1570 verbenone 133 µM 1.34523878199098 0.0873142922278842 no 330 0.0892740679302476 116 29025 A natural terpanoid with antifungal properties.
SGTC_2873 9040596 71.43 µM 1.34363634981348 0.0875628193175732 no 331 0.0895330045275973 138 6463863
SGTC_2819 7996655 46.38 µM 1.3433101269208 0.0876134790318219 no 332 0.0895857871579968 84 6456960
SGTC_3118 9124250 49.47 µM 1.34301904049873 0.0876587008033153 no 333 0.0896329042643041 113 1504786
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.34220577383608 0.0877851382534412 no 334 0.0897646424491845 110 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2301 7769476 200 µM 1.34190684571248 0.0878316463727681 no 335 0.0898131009149795 121 977820
SGTC_1312 1218-2183 165 µM 1.34171893516853 0.087860891455619 no 336 0.0898435725597344 121 6744073
SGTC_1548 st061468 90.8 µM 1.34048854495372 0.0880525602704297 no 337 0.0900432830046779 98 390799
SGTC_1454 4239-0054 42.6 µM 1.34022554469175 0.0880935705685507 no 338 0.0900860145747744 124 1340767
SGTC_716 1683-5115 658 µM 1.33700997541294 0.0885961343946762 no 339 0.0906096903508201 129 723597
SGTC_2281 7943571 200 µM 1.33692838091896 0.0886089145874444 no 340 0.0906230078641314 127 1244024
SGTC_447 ml7 120 µM 1.33445783293873 0.0889965284896157 no 341 0.0910269286917881 93 4216 Selective myosin light chain kinase inhibitor.
SGTC_2130 NSC 7 2.4545 µM 1.332911795652 0.0892397335239502 no 342 0.0912803755831271 122 21448
SGTC_189 3970-0742 2.116 µM 1.33202746959764 0.0893790678014154 no 343 0.0914255810373986 115 2891807
SGTC_1172 0370-0043 85 µM 1.32670533945599 0.0902210410819483 no 344 0.0923030870070058 102 376585
SGTC_1751 st044839 27.194 µM 1.32505180870676 0.0904838292818068 no 345 0.0925769841609172 109 5291326
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.32047837831035 0.0912136230290044 no 346 0.0933376751451227 113 4213774
SGTC_298 1391-0729 10 µM 1.31819155980635 0.0915801690985573 no 347 0.0937197651053666 116 3237558
SGTC_3346 9158254 43.5805 µM 1.3179764685906 0.091614701391529 no 348 0.0937557626571972 141 17639500
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.31710754936146 0.0917543021651886 no 349 0.0939012884282084 108 2374 Ca(2+)-ATPase inhibitor.
SGTC_282 k297-0036 65.7 µM 1.31395238828094 0.0922625361543364 no 350 0.0944311135799388 122 5061378
SGTC_483 fpl-64176 144 µM 1.31229882320453 0.0925297234755903 no 351 0.0947096645362119 103 3423
SGTC_625 k213-0058 121 µM 1.3110447050489 0.0927327485302558 no 352 0.094921330215482 155 3655420
SGTC_11 0438-0307 1.3 µM 1.31016543772142 0.0928752865514767 no 353 0.0950699375727518 133 4011476
SGTC_185 k048-0037 25.491 µM 1.3027919141265 0.0940769886436871 no 354 0.0963229060208253 100 6827589
SGTC_1692 fluoroquinolonic acid 71 µM 1.30139521377896 0.0943059028663899 no 355 0.0965616055444935 112 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2693 st077581 40.7 µM 1.30107066703415 0.0943591536952959 no 356 0.0966171335482017 123 25238761
SGTC_822 1487-0950 154 µM 1.30054611308311 0.0944452680908064 no 357 0.0967069311730216 107 1958375
SGTC_1341 1486-1360 280 µM 1.2994881459221 0.0946191275530982 no 358 0.0968882294843854 126 3976547
SGTC_1199 1638-0010 4.46 µM 1.29885837248784 0.0947227323865958 no 359 0.0969962688898499 132 3111136
SGTC_808 0711-0032 135 µM 1.29688498294261 0.095047918650774 no 360 0.0973353821175109 139 4252555
SGTC_2605 digitonin 300 nM 1.29651839385596 0.0951084177267139 no 361 0.0973984735764059 151 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1116 jasmonic acid 1.58368 µM 1.2947414378981 0.095402074987986 no 362 0.0977047200233345 128 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2791 5663188 71.43 µM 1.28540185527752 0.0969565000152921 no 363 0.0993259466154715 150 54690634
SGTC_2167 5876490 200 µM 1.2837251979632 0.0972375104535755 no 364 0.0996190622570928 116 686534
SGTC_507 nimesulide 162 µM 1.28337989066961 0.0972954586464809 no 365 0.0996795077871356 128 4495 A COX2 inhibitor.
SGTC_1972 st070201 17.4 µM 1.28020159962534 0.097830017950744 no 366 0.100237121752216 128 2829099
SGTC_2738 aclarubicin 5.55 µM 1.27966592113896 0.0979203257362657 no 367 0.100331327425074 85 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2743 auranofin 4.32 µM 1.27630333983072 0.0984886049970345 no 368 0.100924155013311 94 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_583 1488-1091 88.9 µM 1.27214832773305 0.0991941363522649 no 369 0.101660211450353 149 4303273
SGTC_3336 9143619 71.43 µM 1.27177132278855 0.0992583351494095 no 370 0.101727190432753 105 45595730
SGTC_3069 9117009 49.47 µM 1.26805212110204 0.0998932932314893 no 371 0.102389669031116 108 41904981
SGTC_1176 0848-0131 83.3 µM 1.26522452546761 0.100378013903167 no 372 0.102895426567586 128 6769040
SGTC_1720 st037298 9.481 µM 1.2650104969783 0.10041477349993 no 373 0.102933782509049 139 597396
SGTC_170 4197-0004 226 µM 1.26398273393324 0.100591429627673 no 374 0.103118112128763 140 218692
SGTC_2610 ononetin 44.17 µM 1.26387795608388 0.10060945200071 no 375 0.103136917525649 116 259632
SGTC_1201 1889-3372 45.9 µM 1.25158092119197 0.102741001381629 no 376 0.105361305099963 130 5392199
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.24817577636967 0.103337005007452 no 377 0.105983346434615 119 140250 A respiratory chain inhibitor.
SGTC_1224 0823-0416 294 µM 1.23841278165288 0.105059731636304 no 378 0.107781521847566 128 3598164
SGTC_672 1441-0018 53.7 µM 1.23828612769621 0.105082216088964 no 379 0.10780499284244 111 251141
SGTC_1184 1269-1718 139 µM 1.23404406426135 0.105837308310121 no 380 0.108593242512237 135 5403821
SGTC_2955 9076254 12.21 µM 1.23399105262713 0.105846769189318 no 381 0.108603119160431 123 16459619
SGTC_2976 9009005 19.48 µM 1.23352674970011 0.105929658517774 no 382 0.108689651495295 105 2993148
SGTC_774 k060-0086 136 µM 1.2334247984283 0.105947865570812 no 383 0.108708658834835 141 5911235
SGTC_2288 7946289 167.31 µM 1.23149976561637 0.10629207374659 no 384 0.109068002135335 133 1246052
SGTC_751 0833-0568 350 µM 1.23077833071269 0.106421278751623 no 385 0.109202891099263 130 6954252
SGTC_360 0957-0399 1.01 µM 1.23026252566881 0.106513726084999 no 386 0.109299406258115 131 6752301 YPR165W RHO1
SGTC_352 k048-0007 5.11 µM 1.22836167655285 0.106854914280497 no 387 0.109655613745656 168 6811911
SGTC_591 4299-0174 154 µM 1.22656814377385 0.107177562357801 no 388 0.109992474298597 132 5509088
SGTC_2639 lactacystin 53 µM 1.22601446131266 0.107277308986531 no 389 0.110096616536988 121 3870 A proteasome inhibitor.
SGTC_654 1124-0271 80.9 µM 1.22577768227197 0.107319985468742 no 390 0.110141173937942 145 5403748
SGTC_3291 9121177 71.43 µM 1.22020069000948 0.108328710467532 no 391 0.111194402686335 113 17015612
SGTC_1354 1498-1681 81 µM 1.21921081738824 0.108508461953374 no 392 0.111382093629982 144 5754243
SGTC_1738 st035555 74 µM 1.21821082517761 0.108690268834576 no 393 0.111571933503077 149 5331140
SGTC_2571 chrysanthemic acid 100 µM 1.21571458161552 0.109145062369801 no 394 0.112046833755289 139 2743 An insecticide.
SGTC_1207 2099-0101 141 µM 1.21454403124126 0.109358796647401 no 395 0.11227002325852 142 5837381
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.2055731370089 0.111006805310079 no 396 0.113991061087035 115 1241132 A phosphatase inhibitor.
SGTC_2898 9056270 58.44 µM 1.20103250994915 0.111847693982714 no 397 0.114869295382609 97 19154699
SGTC_1445 4239-0156 97.7 µM 1.19984863604099 0.112067684971443 no 398 0.115099065661227 148 4008346
SGTC_2216 7189485 200 µM 1.19852118736058 0.112314723131091 no 399 0.115357089857953 125 731273
SGTC_1000 4048-0884 8.67 µM 1.19783863761585 0.112441896992997 no 400 0.115489921082547 135 13040088
SGTC_972 1319-0219 195 µM 1.19488808517463 0.112992832608746 no 401 0.116065379330871 154 23903702
SGTC_1867 st057372 64 µM 1.19155322455469 0.113617843615959 no 402 0.116718237601272 120 688837
SGTC_2413 inermin 26.06 µM 1.19134812569897 0.113656363011656 no 403 0.116758474167822 178 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3323 9138564 53.9225 µM 1.18865359972436 0.114163283781576 no 404 0.117288003279576 146 43912313 YNL103W MET4
SGTC_1772 st048439 82.2 µM 1.18474038776034 0.114902340007813 no 405 0.118060054302514 141 2927068 YDL195W SEC31
SGTC_2052 5265182 7.135 µM 1.18372396035728 0.115094859849831 no 406 0.118261175515316 143 1239884
SGTC_1401 3807-4679 7.6 µM 1.17895033495324 0.116002092403127 no 407 0.119208976408704 157 3291456
SGTC_257 daunorubicin 18.5 µM 1.17762773473961 0.11625434970965 no 408 0.119472523985041 142 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2015 5119600 184 µM 1.17687928885398 0.11639727187129 no 409 0.119621844852654 167 2828786
SGTC_1705 st027868 56.3335 µM 1.17408081726996 0.116932768242206 no 410 0.120181328107245 122 292948
SGTC_802 4112-3352 742 µM 1.17347563775753 0.117048800507291 no 411 0.12030256045548 136 704594
SGTC_1468 k284-1086 134 µM 1.17312667579695 0.117115744748078 no 412 0.120372505271407 159 15996457
SGTC_1717 st033143 58.0435 µM 1.17189251938526 0.117352720719482 no 413 0.120620105400099 128 674616
SGTC_2303 7774051 200 µM 1.17167831519148 0.117393885598714 no 414 0.120663116175373 147 2953184
SGTC_33 0986-0033 35.816 µM 1.16470055462441 0.118740438454142 no 415 0.122070112207891 115 2848082
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.16421532585761 0.118834480952291 no 416 0.122168380438504 132 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2627 acetyl isogambogic acid 100 µM 1.16344012467591 0.118984832328038 no 417 0.122325488926582 140 6857789 A caspase activator and apoptosis inducer.
SGTC_3313 9133968 57.047 µM 1.16291365057338 0.119087019292641 no 418 0.122432269218543 147 1494643
SGTC_2523 spermine 47.74 µM 1.1623549821097 0.119195522822948 no 419 0.122545650737243 127 1103 A DNA binding polyamine.
SGTC_2828 7998861 71.43 µM 1.16195367973692 0.119273506063354 no 420 0.122627140329905 110 2988188
SGTC_2993 9054257 71.4286 µM 1.16187731439218 0.119288349865946 no 421 0.122642651596642 165 6470217 YGL055W OLE1
SGTC_3293 9120939 62.045 µM 1.15676324990855 0.120285384151183 no 422 0.123684550137958 144 934087
SGTC_2813 7971799 71.43 µM 1.152792960434 0.121063466534663 no 423 0.124497687243051 154 2234054
SGTC_1927 st060202 13.8 µM 1.15202269672128 0.121214829107326 no 424 0.124655873394536 149 688887
SGTC_71 0417-1750 47.813 µM 1.14978532833563 0.121655243327797 no 425 0.125116149775771 158 6811472
SGTC_464 bw-b 70c 158 µM 1.14650478514998 0.122303032281235 no 426 0.125793174211831 158 5353454
SGTC_176 1486-1328 72.834 µM 1.14508175368885 0.122584781267497 no 427 0.126087646556294 155 22310231
SGTC_1770 st043884 66.3 µM 1.14308484967927 0.122980919857301 no 428 0.126501681958388 182 670149
SGTC_2981 9013952 38.96 µM 1.13781159915614 0.124031319625625 no 429 0.127599580250636 144 2996344
SGTC_2803 7707263 71.43 µM 1.13723323020996 0.124146908133946 no 430 0.127720399404229 132 2199229
SGTC_1961 st076550 68.7 µM 1.1326001667377 0.12507555773556 no 431 0.128691099300181 161 1579337
SGTC_1264 0783-0040 158 µM 1.13140481146871 0.125315939661625 no 432 0.128942373653245 138 2855798
SGTC_1985 st071382 65.5 µM 1.13052472097776 0.12549312892313 no 433 0.129127593884706 165 6123237
SGTC_1626 st003712 1.76 µM 1.12749017602496 0.126105416556083 no 434 0.129767645883945 183 24207035
SGTC_667 1498-1044 59 µM 1.12491226781198 0.126627201069451 no 435 0.130313106455864 159 6739982
SGTC_2445 5742597 35.57 µM 1.12233826699031 0.127149693059313 no 436 0.130859320748378 173 1774255
SGTC_2172 5754775 163.918 µM 1.1201301502426 0.127599108739523 no 437 0.131329152062718 186 2263357
SGTC_1375 2910-0797 186 µM 1.117538375752 0.128128017266217 no 438 0.13188210037806 142 742508
SGTC_749 1000-0129 128 µM 1.11688357832771 0.128261883677968 no 439 0.132022053454693 148 708470
SGTC_3226 9131256 49.47 µM 1.11309527754827 0.129038267917261 no 440 0.132833755841609 145 17178073
SGTC_991 3996-0057 64.7 µM 1.11123045654834 0.129421643688265 no 441 0.133234582366955 149 715343
SGTC_3049 9092223 49.47 µM 1.11067283059231 0.129536435321529 no 442 0.133354600531262 133 8623917
SGTC_123 0083-0120 66.675 µM 1.10685638307283 0.130323974039753 no 443 0.134178013145981 187 16001701
SGTC_2594 a-mangostin 100 µM 1.10636729310264 0.130425138576935 no 444 0.134283788024657 166 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_52 0329-0193 875 nM 1.10541929298153 0.130621379824834 no 445 0.134488973867178 171 3739292
SGTC_2737 bleomycin 30.5 nM 1.1052453539051 0.130657408325708 no 446 0.134526644725129 167 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1268 0828-0275 2.46 µM 1.10361722346523 0.130994980807903 no 447 0.134879608320191 168 745337
SGTC_1854 st056233 32.9 µM 1.10326445644216 0.131068201996004 no 448 0.134956168605368 168 5393174
SGTC_1125 tnp00248 1.32998 µM 1.1025075376383 0.131225405325537 no 449 0.135120541681378 182 24207736
SGTC_77 0828-0286 12.516 µM 1.10043754380501 0.131655984072619 no 450 0.135570764013915 144 745345
SGTC_2771 fluoxetine 41.05 µM 1.09766203386052 0.132234845597625 no 451 0.136176046995869 145 3386 A selective serotonin reuptake inhibitor.
SGTC_1633 st005664 67.9 µM 1.09749003054166 0.132270776327528 no 452 0.13621361822843 146 2063822
SGTC_1263 0774-1208 64.8 µM 1.09635429221634 0.132508195949316 no 453 0.136461879222686 184 906585
SGTC_1618 st003135 44.5 µM 1.09587828084299 0.132607790683511 no 454 0.136566022514781 170 1270615
SGTC_1433 4060-0023 7.6 µM 1.09470961587192 0.132852526371758 no 455 0.136821937266376 170 3840627
SGTC_3315 9136395 68.55 µM 1.09402074780791 0.132996931115038 no 456 0.136972939353488 204 16876844
SGTC_1818 st052136 56.3 µM 1.09296903973326 0.133217604949746 no 457 0.137203696719214 174 674169
SGTC_84 0443-0269 128.823 µM 1.09260757520909 0.133293507110522 no 458 0.137283067652927 159 6150058
SGTC_2207 7258803 200 µM 1.09089028331853 0.133654519247245 no 459 0.13766058158527 164 3666799
SGTC_2038 4100038 30.985 µM 1.09047836583149 0.133741213144089 no 460 0.137751239058593 178 3596803
SGTC_1973 st070275 50.2 µM 1.0899973438934 0.133842499976442 no 461 0.137857157042397 130 17118334
SGTC_2851 9015922 71.43 µM 1.08968328847079 0.133908657790579 no 462 0.137926340029803 174 2996893
SGTC_2474 5321570 43.32 µM 1.08955597562332 0.133935483469486 no 463 0.137954392408176 162 2841384
SGTC_724 3910-0327 137 µM 1.08685100386626 0.134506312214716 no 464 0.138551331363405 175 2885483
SGTC_780 0109-0199 192 µM 1.08367708062347 0.135178230306201 no 465 0.139254000571913 180 610414
SGTC_23 0213-0011 39.996 µM 1.08350412984176 0.135214909909517 no 466 0.139292359381709 171 627608
SGTC_2032 5185112 25.99 µM 1.08126886776888 0.135689580903518 no 467 0.13978876580592 150 5718189
SGTC_2102 5377816 72.7585 µM 1.08024158641576 0.135908112491859 no 468 0.140017307045234 177 1379702
SGTC_1719 st032227 49.2 µM 1.07064543838105 0.137961122415987 no 469 0.142164442194668 160 3125804
SGTC_2386 9075165 157.42 µM 1.07050023500851 0.137992348981852 no 470 0.142197101626685 170 16452277
SGTC_1853 st056710 91.2 µM 1.06921847397883 0.138268205915235 no 471 0.142485618096855 178 269167
SGTC_2671 danthron 100 µM 1.06917521531611 0.138277522473912 no 472 0.142495362255847 176 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1812 st052057 4.327 µM 1.06653328797932 0.138847321983014 no 473 0.143091319625942 159 3645418
SGTC_552 k242-0005 476 µM 1.06578451883692 0.139009103674672 no 474 0.143260530342405 178 4088318
SGTC_318 1488-0629 67.2 µM 1.06575229328978 0.139016069318797 no 475 0.143267815869909 156 3662576
SGTC_2359 9039622 200 µM 1.06401426800259 0.139392100474749 no 476 0.143661118016873 171 6463596
SGTC_2123 5259487 200 µM 1.06247272736993 0.139726199644605 no 477 0.144010566349391 163 2173474
SGTC_1106 tegaserod maleate 11.7 µM 1.05834521961661 0.140623435917909 no 478 0.144949042096833 188 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1220 1838-0075 193 µM 1.05601733806715 0.141131191017737 no 479 0.1454801468579 164 5529645
SGTC_1875 nocodazole 6 µM 1.05468303978459 0.14142278658915 no 480 0.145785155547351 180 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1561 5-methoxyflavone 52.9 µM 1.05467149390691 0.141425311588708 no 481 0.145787796706415 156 94525
SGTC_828 2074-0507 139 µM 1.05320107518226 0.141747131207349 no 482 0.146124422906692 167 X828
SGTC_3165 9101544 49.47 µM 1.05287781653743 0.141817946878098 no 483 0.146198497173156 175 5002184
SGTC_3176 9106582 49.47 µM 1.05112698379965 0.142201914814238 no 484 0.146600136206944 116 17018027
SGTC_342 k048-0088 23.3 µM 1.04623835966812 0.143277740632999 no 485 0.147725498242547 180 6820570
SGTC_1200 1643-0193 18.4 µM 1.04591741051012 0.143348562791747 no 486 0.14779958262305 187 5403974
SGTC_2866 9034245 58.44 µM 1.04138325972099 0.144351615903542 no 487 0.148848854361567 152 6462273
SGTC_1604 st002052 72.4 µM 1.04104743894405 0.144426094485156 no 488 0.14892676592498 149 6254834 YHR062C RPP1
SGTC_1133 3473-0247 50 µM 1.03955100055771 0.144758290460206 no 489 0.149274275909062 188 711311
SGTC_517 1365-0151 113 µM 1.03742141122451 0.145231926885458 no 490 0.149769752010057 163 768657
SGTC_120 rhodamine 6G 52.259 µM 1.03588511711673 0.145574256802828 no 491 0.150127870837256 217 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1496 4469-0713 57.4 µM 1.03506366311431 0.145757522509611 no 492 0.1503195904216 166 746691
SGTC_2217 6934799 96.0675 µM 1.03443059894012 0.145898864371146 no 493 0.150467452872148 172 675606
SGTC_1744 st037937 38.9 µM 1.03435533154719 0.145915675163733 no 494 0.150485039240487 175 1016152
SGTC_748 act1.228 77.9 µM 1.03230826457789 0.146373381802718 no 495 0.150963865337451 157 4421505 YNR035C ARC35
SGTC_2787 5284540 71.43 µM 1.03027288878934 0.146829429125277 no 496 0.151440961034971 187 736958
SGTC_629 3448-6466 76.7 µM 1.02759686014013 0.147430470397325 no 497 0.152069750900322 188 573744
SGTC_3217 9129673 49.47 µM 1.02668004446731 0.147636767615811 no 498 0.152285574457635 179 17248312
SGTC_2050 5263056 171 µM 1.02514875260671 0.147981762119559 no 499 0.152646502390632 176 763468 YGL055W OLE1
SGTC_720 r052-1644 49.9 µM 1.02389756834591 0.148264049667852 no 500 0.152941829446823 186 1422863 YOR257W CDC31
SGTC_271 rotenone 740 µM 1.01997703819849 0.149150916770396 no 501 0.153869675413313 168 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_945 3381-0768 11.3 µM 1.01926477623398 0.149312417791634 no 502 0.154038640793308 186 1126236 YIL048W NEO1
SGTC_3330 9141424 71.43 µM 1.01778658396841 0.149647961264042 no 503 0.154389694551048 165 27261020
SGTC_837 0091-0265 12.5 µM 1.0162437114982 0.149998723101185 no 504 0.154756672867564 195 759367
SGTC_1323 1348-1351 11.2 µM 1.01413834773326 0.150478247344488 no 505 0.155258370995618 178 6989654
SGTC_195 4234-0266 16.654 µM 1.01233950997781 0.150888764410561 no 506 0.155687874951078 199 2303354
SGTC_2745 rifampicin 24.3 µM 1.01183578890239 0.151003853279379 no 507 0.155808287463959 115 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2852 9023854 51.95 µM 1.01135652608036 0.151113408209841 no 508 0.155922910318135 200 19798528
SGTC_1294 1000-1494 117 µM 1.01026879989624 0.151362248259222 no 509 0.156183262451757 151 712797 YDL207W GLE1
SGTC_2820 7989630 71.43 µM 1.00957814130634 0.151520392186274 no 510 0.156348723263452 130 2984098
SGTC_1954 st077032 68.9 µM 1.00929662438947 0.151584884177677 no 511 0.156416199271146 188 698907
SGTC_2742 clothiapine 36.27 µM 1.00832004175424 0.151808748424714 no 512 0.156650422284892 135 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_113 0099-0221 2.5 µM 1.00790724898153 0.151903439865029 no 513 0.156749495647482 174 89219
SGTC_3111 9122088 49.47 µM 1.00662386753636 0.152198088142842 no 514 0.157057780173716 161 16876704
SGTC_219 mitoxanthrone 164.414 µM 1.00415448858776 0.152766093431086 no 515 0.157652077492052 186 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1801 st050089 28.441 µM 1.00354615074742 0.15290623855498 no 516 0.157798710675991 185 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_343 4130-2827 29.8 µM 1.00179220691056 0.153310778401077 no 517 0.158221980932275 161 1118244
SGTC_612 0302-0167 22.4 µM 1.00126283618357 0.153433014736894 no 518 0.158349877487157 201 235821
SGTC_2641 levomentholum 100 µM 0.99807716786608 0.154169976303125 no 519 0.159120970332928 177 16666
SGTC_859 0439-0102 54.6 µM 0.997163198060026 0.154381842448409 no 520 0.159342650573962 201 610143
SGTC_2252 omeprazole 400 µM 0.996810810215608 0.154463580407908 no 521 0.159428175025958 155 4594 A proton pump inhibitor.
SGTC_3190 9110366 49.47 µM 0.995368096774986 0.154798522613459 no 522 0.159778634585206 159 17123768
SGTC_338 4055-0136 114 µM 0.995085813252403 0.154864114001982 no 523 0.159847264950933 163 2900563
SGTC_3305 9127027 53.8275 µM 0.9943418436186 0.155037070696515 no 524 0.160028235423963 197 41905295
SGTC_2487 5918373 44.05 µM 0.994066418774966 0.155101133297143 no 525 0.160095266432815 209 2876279
SGTC_1040 k898-0338 155 µM 0.993000349340627 0.15534926105819 no 526 0.160354892115468 208 20969351
SGTC_1166 k206-0078 225 µM 0.992955006742215 0.155359820356833 no 527 0.160365940741566 182 5404595
SGTC_371 0195-0006 7.36 µM 0.992632591360007 0.155434917499444 no 528 0.160444518007811 177 3928593
SGTC_2396 5342950 42.78 µM 0.99248908987126 0.155468349635047 no 529 0.160479499473354 230 1886677
SGTC_1805 st050013 60.3 µM 0.989308186853837 0.156210635852394 no 530 0.161256189866552 183 4037144
SGTC_1157 4092-0394 27.6 µM 0.989175856373545 0.15624156661097 no 531 0.161288554426987 162 3659885
SGTC_2885 9057732 51.95 µM 0.987972496841574 0.15652302349705 no 532 0.161583059005068 214 6471414
SGTC_2518 prenyletin 46.28 µM 0.987378423926692 0.156662095761994 no 533 0.161728578799719 151 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1988 st071872 53.4 µM 0.987171086426989 0.156710652540963 no 534 0.161779386790678 165 16414116
SGTC_313 3474-0040 5.03 µM 0.986679234791197 0.156825879864629 no 535 0.161899956483325 199 1043375 YIL048W NEO1
SGTC_201 4262-0159 12.803 µM 0.98615327695573 0.156949159003082 no 536 0.162028951529306 180 1341029
SGTC_2651 TUB2.036 5 µM 0.985381726051478 0.157130117972391 no 537 0.162218301184452 199 15992207 YFL037W TUB2
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.983965590195864 0.15746261431511 no 538 0.162566215966506 206 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3225 9130819 49.47 µM 0.979442954576522 0.158527583963101 no 539 0.163680580951195 196 4547121
SGTC_1438 4092-1045 4 µM 0.979325399198654 0.158555328210784 no 540 0.16370961224391 201 1351342
SGTC_1075 aripiprazole 15.2 µM 0.97700811487394 0.159102880561837 no 541 0.16428256747572 181 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2138 5575593 77.673 µM 0.976854195276801 0.159139294126299 no 542 0.16432067053578 179 762213
SGTC_1330 1469-0054 61.8 µM 0.974736049975129 0.159640949277603 no 543 0.164845602952495 188 7102664
SGTC_3042 9091578 49.47 µM 0.97427171639541 0.159751058789524 no 544 0.164960822080121 179 25236497
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.97349133447778 0.159936226170258 no 545 0.16515458246972 184 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2879 9041815 71.43 µM 0.973410222641888 0.159955480266262 no 546 0.165174730109521 150 4942971
SGTC_485 niflumic acid 177 µM 0.973204338605317 0.160004359238104 no 547 0.165225877476595 184 4488 A COX2 inhibitor.
SGTC_1340 1486-1359 257 µM 0.973092354355006 0.160030949542997 no 548 0.165253701807597 194 4309068
SGTC_2748 diazoxide 86.69 µM 0.967337209961994 0.161401380171131 no 549 0.166687743987521 135 3019 A potassium channel activatior.
SGTC_2954 9074818 52.69 µM 0.966023814038561 0.161715199025195 no 550 0.167016132443902 200 16648742
SGTC_2507 purpurin 79.67 µM 0.965706963215102 0.161790965904071 no 551 0.167095417095926 205 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2041 5107442 45.335 µM 0.965702735709997 0.16179197696159 no 552 0.167096475096153 213 793005
SGTC_2272 7805186 180 µM 0.965489894065536 0.161842885863504 no 553 0.167149747677683 217 2956062 YPR165W RHO1
SGTC_3243 9134147 49.47 µM 0.965334420401689 0.161880079700363 no 554 0.167188668426732 196 24282180
SGTC_1208 2323-2347 50.3 µM 0.963907062343098 0.162221805629359 no 555 0.167546261393981 178 5412760
SGTC_443 clozapine 122 µM 0.96388046413902 0.16222817799964 no 556 0.16755292965808 189 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_80 0159-0065 512.242 µM 0.963730526101896 0.162264103048616 no 557 0.167590522853962 171 1548079
SGTC_2178 5812956 200 µM 0.963719631908805 0.162266713491485 no 558 0.167593254510884 203 5403383
SGTC_1851 st056236 18.9 µM 0.961454233765693 0.16281013721207 no 559 0.168161913223762 191 5393171
SGTC_2284 7945075 39.21 µM 0.959995049354817 0.163160792330354 no 560 0.168528853271643 209 1245402
SGTC_561 1550-0330 72.9 µM 0.957533491916197 0.16375343816652 no 561 0.169149025059476 190 6812934
SGTC_2496 diffractaic acid 79.83 µM 0.955240483435827 0.16430675953121 no 562 0.169728048750704 190 94870 An apoptosis inducer which activates caspases.
SGTC_2963 9082507 9 µM 0.954966948473371 0.164372846553227 no 563 0.169797205756055 196 16459611
SGTC_2568 diosmetin 100 µM 0.953264929553257 0.164784447543633 no 564 0.170227927927703 223 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1742 st038235 28.8875 µM 0.952854881641437 0.164883709566456 no 565 0.17033180143525 210 564103 YBR002C RER2
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.952780521569591 0.16490171436896 no 566 0.170350642707755 219 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1309 pyrazolanthrone 13.4 µM 0.951386719412663 0.16523943124388 no 567 0.170704049756619 205 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_807 1315-0151 48 µM 0.951052347729943 0.165320515694829 no 568 0.170788901485109 226 4011080
SGTC_2057 5236571 38.335 µM 0.94505629586884 0.166778915267301 no 569 0.172315068001069 180 54684039 YBR257W POP4
SGTC_278 4092-0821 23.9 µM 0.944829864407869 0.166834151594208 no 570 0.172372871253977 189 877900
SGTC_1572 epiandrosterone 68.9 µM 0.943479893058673 0.167163712289424 no 571 0.172717747584123 173 441302 A steroid.
SGTC_2439 5492030 7.2 µM 0.939699433108903 0.16808884575111 no 572 0.173685878007885 201 5722370
SGTC_2310 7668677 200 µM 0.938824164949212 0.168303505388834 no 573 0.173910514927253 213 2197143
SGTC_2488 5268135 45.7 µM 0.937923235309158 0.16852464257921 no 574 0.17414193071183 201 1270356 YLR208W SEC13
SGTC_2725 haloperidol 53.21 µM 0.936340393501008 0.16891361032924 no 575 0.17454897848547 215 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1103 duloxetine 36.1 µM 0.93467421108636 0.169323680785009 no 576 0.174978110589081 206 60835 A selective serotonin reuptake inhibitor.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.933684936952473 0.169567456862234 no 577 0.175233218643815 212 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2433 5607874 27.82 µM 0.927025055478778 0.17121443539907 no 578 0.176956762747923 217 2252428
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.925165815900605 0.171676042810169 no 579 0.177439830985579 196 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_544 k015-0020 52.4 µM 0.923798161598441 0.172016107667677 no 580 0.177795706270016 206 3008304
SGTC_1743 st037606 46.3785 µM 0.922623371412309 0.172308560292351 no 581 0.178101755889581 163 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2918 7977171 22.06 µM 0.922522012010767 0.17233380758924 no 582 0.178128177015456 203 2236483
SGTC_2103 5378138 10 µM 0.92246346421997 0.172348392150932 no 583 0.178143439661348 204 244142
SGTC_2263 7948595 193.29 µM 0.922371101841347 0.172371401704602 no 584 0.178167519005472 189 2971371
SGTC_2114 5491910 81.25 µM 0.922053696390171 0.172450489505688 no 585 0.178250283867034 201 2849228
SGTC_2870 9038528 12.99 µM 0.920622995483656 0.172807263950345 no 586 0.178623646079574 196 6463316
SGTC_1587 estradiol valerate 56.1 µM 0.919717803022563 0.173033234947409 no 587 0.178860123390162 222 13791 A steroid.
SGTC_3100 9120536 49.47 µM 0.918293131022744 0.173389269196959 no 588 0.17923271122941 188 16421196
SGTC_3075 9116269 49.47 µM 0.916318409597702 0.173883534754145 no 589 0.179749957506807 197 17015205 YNL244C SUI1
SGTC_2126 5251174 33.877 µM 0.911320787482106 0.175138419921876 no 590 0.181063188343206 190 790722
SGTC_2401 5128683 200 µM 0.910195762761078 0.175421699801368 no 591 0.181359639190593 202 708373
SGTC_2093 5331342 194.4 µM 0.908775968199434 0.175779616712648 no 592 0.181734197184459 212 33839
SGTC_1559 coumarin 343 70.1 µM 0.908066239831079 0.175958705880732 no 593 0.181921612919086 200 108770 A hepatotoxic, DNA x-linker.
SGTC_448 monastrol 171 µM 0.907674598524338 0.176057580064232 no 594 0.182025084138809 231 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3260 9137109 49.47 µM 0.90686837869417 0.176261229893471 no 595 0.182238202379531 201 17478346
SGTC_2634 4'-methoxyflavone 100 µM 0.904266721691829 0.176919420446325 no 596 0.182926994112987 177 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2435 5706476 10.6 µM 0.903612251999255 0.17708523826687 no 597 0.183100521154073 195 5725375
SGTC_2736 butenafine 14.65 µM 0.902271245593849 0.17742530504902 no 598 0.183456398170593 200 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2700 st077718 96.8 µM 0.902100962255522 0.177468516803827 no 599 0.183501618887895 202 904970
SGTC_1500 4488-1866 171 µM 0.901955015473473 0.177505558107055 no 600 0.183540382278846 218 2900003
SGTC_50 0929-0078 56.389 µM 0.901708538300006 0.177568125109288 no 601 0.183605858076706 190 1377751
SGTC_31 0508-1974 57.237 µM 0.899943671798416 0.178016534223398 no 602 0.184075113830267 186 6810525
SGTC_2426 5582046 32.21 µM 0.897146580739162 0.178728667217038 no 603 0.184820352836562 199 2251934
SGTC_805 3852-0218 479 µM 0.896782360981866 0.178821528537112 no 604 0.184917531021261 206 6615355
SGTC_1223 0764-0573 147 µM 0.896687959874014 0.178845601959914 no 605 0.184942723545708 196 1609797
SGTC_2128 5255449 168.493 µM 0.896683413872064 0.178846761296803 no 606 0.184943936776661 191 736008
SGTC_2375 9072683 200 µM 0.896451485478456 0.178905914741849 no 607 0.185005840080138 222 16798029
SGTC_2746 daunorubicin 9.88 µM 0.896376915677112 0.178924936420139 no 608 0.185025746014069 177 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2491 paeonol 100 µM 0.896055950096794 0.179006824627978 no 609 0.185111440922271 203 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3266 9136860 49.47 µM 0.894125056854492 0.179499952509217 no 610 0.185627492091574 219 4871271 YPR165W RHO1
SGTC_1887 st057648 70.8 µM 0.892246092888763 0.179980637178819 no 611 0.186130520689562 225 688672
SGTC_2831 7999036 19.48 µM 0.891916713189767 0.180064983706383 no 612 0.186218787841807 205 2988270
SGTC_98 0074-0023 107.663 µM 0.891716114326147 0.180116364596139 no 613 0.186272557020655 191 3563821
SGTC_1975 st070967 30.8 µM 0.891183559722509 0.180252816443107 no 614 0.186415351372008 235 261391
SGTC_934 2950-0684 338 µM 0.890702990583905 0.180376004174764 no 615 0.18654426499772 222 1121253
SGTC_2443 5493264 126.67 µM 0.890679810211104 0.180381947500945 no 616 0.186550484574123 222 5340055
SGTC_130 0136-0219 337.655 µM 0.890431807476288 0.180445541792307 no 617 0.186617034765167 247 234244
SGTC_619 1652-1634 108 µM 0.888863855470308 0.180847930582137 no 618 0.187038126372835 202 5400454
SGTC_921 1561-0023 372 µM 0.888083434119819 0.181048422211307 no 619 0.187247936448409 214 24050882
SGTC_2299 7976368 114.88 µM 0.887774405186247 0.181127850767296 no 620 0.187331056626673 201 2979718
SGTC_776 4476-4378 112 µM 0.887453143815844 0.181210446519312 no 621 0.187417491168828 220 2892008
SGTC_474 dl-dihydrosphingosine 5 µM 0.886686383263945 0.181407674675403 no 622 0.187623885722009 202 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2290 7904846 200 µM 0.885427624867826 0.181731747085883 no 623 0.187963019298119 207 2962154
SGTC_2657 nystatin 74.44 µM 0.883805932076712 0.182149791952677 no 624 0.188400491793465 209 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_386 1509-0011 3.07 µM 0.881983749328516 0.182620236275728 no 625 0.188892797638736 207 3107280
SGTC_3105 9121040 49.47 µM 0.881916305509713 0.182637663217296 no 626 0.188911034383076 178 41448907
SGTC_3188 9110789 49.47 µM 0.879308213242885 0.18331236970295 no 627 0.189617091917919 205 849217
SGTC_2835 9006588 71.43 µM 0.878338835189184 0.183563540892935 no 628 0.189879933302195 183 2345538
SGTC_2315 7733312 200 µM 0.876218203720903 0.184113755553993 no 629 0.190455711094483 203 726316
SGTC_1333 1482-0047 286 µM 0.871075439762906 0.185452344445122 no 630 0.191856481663011 212 3811116
SGTC_2767 sibutramine 71.45 µM 0.869740424422603 0.185800815281442 no 631 0.192221137693231 204 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3040 9091894 49.47 µM 0.869558028028818 0.185848456604155 no 632 0.192270991700746 190 25236966
SGTC_1117 retinoic acid 1.10837 µM 0.869520671257188 0.185858215001528 no 633 0.192281203321114 207 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2602 kawain 100 µM 0.868738205732321 0.186062684963382 no 634 0.192495169580013 222 5369129
SGTC_2034 5197015 53.07 µM 0.868598002660389 0.186099336852161 no 635 0.192533523671662 231 780676
SGTC_1860 st056228 74.6 µM 0.868413302483806 0.186147628005335 no 636 0.192584057565458 233 688679
SGTC_3129 9127257 49.47 µM 0.867842645277271 0.186296879385909 no 637 0.192740240357398 213 837894
SGTC_3048 9093155 49.47 µM 0.867720601714023 0.186328808643562 no 638 0.192773652422 205 25236002
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.866551569377382 0.18663482475118 no 639 0.193093879569568 218 689007
SGTC_1757 st041620 31.8375 µM 0.863977955491036 0.187309612166633 no 640 0.193800000289641 205 5289815
SGTC_961 1252-1571 372 µM 0.86394729672528 0.187317659807174 no 641 0.193808421591017 230 6813498
SGTC_1332 1480-0653 17.5 µM 0.863176090442047 0.187520164588649 no 642 0.194020328686928 205 5749438
SGTC_146 3448-8650 53.125 µM 0.862517642371878 0.18769316812908 no 643 0.194201364479735 241 2891488 YIL048W NEO1
SGTC_1680 diphenhydramine 100 µM 0.861149631858456 0.188052920323264 no 644 0.194577818389117 220 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1482 3346-2049 8.48 µM 0.859681678851304 0.18843942792233 no 645 0.194982268377473 196 3826804
SGTC_996 3970-0799 1.8 µM 0.858825705159914 0.188665029184612 no 646 0.195218341747465 241 6615648 YGL040C HEM2
SGTC_949 1165-0505 146 µM 0.858699960950696 0.188698184471585 no 647 0.195253036013275 224 6244267
SGTC_1417 3966-0327 90.4 µM 0.856439179027255 0.18929490306317 no 648 0.195877450658359 213 651118
SGTC_1620 st003704 16.5 µM 0.855931735148098 0.189428999015181 no 649 0.196017769997271 216 2834414
SGTC_3252 9135871 49.47 µM 0.855326085180019 0.189589123188752 no 650 0.196185325265347 224 17682838
SGTC_469 w7 172 µM 0.854182241829786 0.189891764152858 no 651 0.196502010504146 210 45115570 A P450 inhibitor.
SGTC_1394 3474-0001 65.7 µM 0.854050013329398 0.189926768645924 no 652 0.196538639339318 182 5017666 YIL048W NEO1
SGTC_3024 9090631 49.47 µM 0.853699419013129 0.190019599731601 no 653 0.196635778073976 205 25236383
SGTC_550 4123-0385 25.7 µM 0.849541340289699 0.19112271009064 no 654 0.197790068442506 214 5731123
SGTC_2515 chrysin 20.77 µM 0.849366853521713 0.191169085941003 no 655 0.197838595631839 207 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_585 0kpi-0023 191 µM 0.845709024671967 0.192142867251645 no 656 0.198857543702232 190 64601
SGTC_2638 epoxomicin 18 µM 0.844749258222967 0.192398876466863 no 657 0.199125425352 203 9915668 A protesome inhibitor.
SGTC_466 geldanamycin 89.2 µM 0.844545250708326 0.192453320534773 no 658 0.199182394155085 191 5288382 HSP90 inhibitor.
SGTC_2298 7976326 193.81 µM 0.843364944806813 0.192768496999164 no 659 0.199512185533858 191 2235818
SGTC_2546 rhodinyl acetate 100 µM 0.843165538711586 0.192821775426399 no 660 0.199567934382459 227 6708682
SGTC_3157 9099274 49.47 µM 0.842273409137546 0.193060249691353 no 661 0.199817465789134 224 17217662
SGTC_2876 9059903 25.97 µM 0.842064411406176 0.193116142690563 no 662 0.199875950222748 205 6916095
SGTC_2175 5807670 165.306 µM 0.841150466970109 0.193360678106726 no 663 0.200131822830167 196 241186
SGTC_2000 st075254 36.4 µM 0.840818551372676 0.193449532352345 no 664 0.200224796348651 218 17234175
SGTC_1402 3909-7673 35.9 µM 0.840400460610894 0.193561491246644 no 665 0.2003419454901 225 5328014
SGTC_863 0466-0191 129 µM 0.835995169556109 0.194743567480999 no 666 0.201578810262734 243 765160 YPR165W RHO1
SGTC_1365 1672-3266 55.4 µM 0.83337658686093 0.195448290837931 no 667 0.20231618750032 237 6415873
SGTC_620 0109-0052 432 µM 0.833140412685421 0.195511927028857 no 668 0.202382771956991 252 493037
SGTC_2005 4024620 188 µM 0.832981285562403 0.195554810292494 no 669 0.202427641968474 229 236743
SGTC_1310 1188-0297 994 nM 0.83279948252539 0.195603811491625 no 670 0.202478913320559 217 1588352
SGTC_2557 derrustone 83.84 µM 0.831714696434088 0.195896347776184 no 671 0.202785001618563 248 629853 An antioxidant.
SGTC_180 1486-1293 102.781 µM 0.831316275796283 0.196003857232063 no 672 0.202897491220373 222 4140536
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.826006748961787 0.197439989328218 no 673 0.204400131685426 199 6708630 An antioxidant.
SGTC_173 1273-0061 2.693 µM 0.825129495734262 0.19767788166846 no 674 0.204649037803086 229 2847414 YPL266W DIM1
SGTC_1715 st032160 10.2275 µM 0.824020707715537 0.197978809025681 no 675 0.204963895954352 207 5289825
SGTC_2201 6605497 169.863 µM 0.822964206201885 0.198265802982419 no 676 0.205264174283463 229 670741
SGTC_3006 9075424 71.4286 µM 0.820121675804881 0.199039209498996 no 677 0.206073373287687 236 7465181
SGTC_1811 st050069 61.5 µM 0.819788538363344 0.19912996966053 no 678 0.206168333066273 238 3877702
SGTC_2412 st077135 33.4 µM 0.819304636585652 0.199261848547228 no 679 0.206306313943748 240 13258915
SGTC_1984 st072354 53.1 µM 0.818142178695472 0.199578870801403 no 680 0.206638003464341 242 5762938
SGTC_2025 5147754 141 µM 0.817711317411149 0.199696451142226 no 681 0.20676102329581 219 315777 YLR208W SEC13
SGTC_2331 7980721 200 µM 0.817643280075742 0.199715022071545 no 682 0.206780453329336 234 2981221
SGTC_3246 9135460 32.98 µM 0.817122376787154 0.199857238111642 no 683 0.206929248180134 232 41446951
SGTC_2380 9035439 200 µM 0.815947937266136 0.200178104779056 no 684 0.207264956580028 220 6462575
SGTC_1283 0922-0125 16.4 µM 0.813881662208644 0.200743379312346 no 685 0.207856373441262 214 3360884
SGTC_3166 9102297 49.47 µM 0.808706004791752 0.202163492520884 no 686 0.209342136688351 236 25237072
SGTC_2276 7947513 42.08 µM 0.808200693058522 0.20230246288457 no 687 0.209487529421684 234 2105100
SGTC_2156 5649887 115 µM 0.807081346173012 0.202610508027905 no 688 0.20980980921662 239 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3054 9094397 49.47 µM 0.806117048296506 0.20287610822375 no 689 0.210087681214444 237 2598354
SGTC_2362 9071156 126 µM 0.80535613440109 0.20308583633524 no 690 0.210307098632864 227 653133
SGTC_3209 9113616 49.47 µM 0.80180160053174 0.204067273892717 no 691 0.211333866337521 243 16649353
SGTC_2724 maprotiline 69.64 µM 0.80090311810771 0.20431579929898 no 692 0.211593867420793 239 4011 A tricyclic antidepressant.
SGTC_276 colchicine 750 µM 0.800439353874289 0.204444149635165 no 693 0.211728143846691 237 2833 A microtubule depolymerizer.
SGTC_3021 9087658 49.47 µM 0.800216880874436 0.204505737786459 no 694 0.211792575476819 221 25237042
SGTC_2245 6637752 200 µM 0.800212453910744 0.204506963433768 no 695 0.211793857710554 223 681890
SGTC_1035 k081-0041 55.2 µM 0.800109752174007 0.204535398620547 no 696 0.211823605701509 239 731709
SGTC_339 3091-4833 71.4 µM 0.800103361815662 0.204537168006575 no 697 0.211825456776528 242 3240077
SGTC_3064 1327-0027 10 µM 0.798948900283286 0.204856969019827 no 698 0.212160021293947 211 16000455 YPR107C YTH1
SGTC_2073 5212005 126 µM 0.797885284931861 0.205151867441792 no 699 0.212468531712847 248 691789
SGTC_2884 9058502 51.95 µM 0.795397999211258 0.205842477273872 no 700 0.213191011716157 228 6471554
SGTC_133 0724-0033 378.92 µM 0.79501755805642 0.205948230535161 no 701 0.213301644368219 230 280309
SGTC_1897 st060201 15 µM 0.794817940556815 0.206003732167097 no 702 0.213359706715453 230 611878
SGTC_254 nsc-64875 3.808 µM 0.7924684627903 0.206657647145898 no 703 0.214043786784862 229 56993
SGTC_161 4065-0411 162.148 µM 0.791976015054921 0.206794862602485 no 704 0.214187330806483 234 1906281 YLR208W SEC13
SGTC_3337 9144342 33.5465 µM 0.791152025166929 0.207024579432772 no 705 0.214427641565556 230 17682949
SGTC_205 1486-1330 71.903 µM 0.790758873506017 0.207134237789991 no 706 0.21454235666358 237 4118834
SGTC_262 fenpropimorph 62.5 µM 0.790352219844534 0.207247698283687 no 707 0.214661048947736 253 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1475 4092-1048 11.7 µM 0.788949639471992 0.207639314322974 no 708 0.215070720637793 243 2881759
SGTC_1828 st055811 49 µM 0.788549344529587 0.207751161269779 no 709 0.215187723712631 245 5877589
SGTC_1027 k015-0025 8.67 µM 0.787717936145851 0.207983579887668 no 710 0.215430855893346 231 3598955
SGTC_1921 5740136 50 µM 0.785062149584847 0.208727027532279 no 711 0.216208565230073 227 1774243
SGTC_2013 4024628 200 µM 0.783847724991474 0.209067508673085 no 712 0.216564733157803 252 5230760
SGTC_1701 st028638 40.4 µM 0.78292219507829 0.209327213573922 no 713 0.216836401477085 233 3490878
SGTC_1285 0929-0069 65.5 µM 0.782423452549652 0.209467240065176 no 714 0.216982877694399 231 1206237
SGTC_3131 9127911 49.47 µM 0.782264132008503 0.209511982364246 no 715 0.217029680760542 239 45595681
SGTC_3216 9129716 49.47 µM 0.781595461219664 0.209699827794334 no 716 0.217226177571261 230 8056934
SGTC_295 k015-0027 31 µM 0.781469564122955 0.209735206339742 no 717 0.217263185412399 240 3887424
SGTC_1096 rimcazole 32.2 µM 0.779005167532077 0.21042843680185 no 718 0.217988335361684 239 18528119 A dopamine reuptake inhibitor.
SGTC_8 0354-0001 70 µM 0.776967045646618 0.211002771784147 no 719 0.218589106599314 237 4993152
SGTC_1038 k292-0204 154 µM 0.776674289952568 0.21108534463605 no 720 0.218675479566143 251 4454212
SGTC_1653 st012112 65 µM 0.776543212773605 0.211122321588092 no 721 0.218714158193866 241 720429
SGTC_3344 9148862 3.898 µM 0.775930126097499 0.211295324108399 no 722 0.218895121828889 250 4905352
SGTC_2549 cedrol 20.94 µM 0.774369873318396 0.211735975056959 no 723 0.219356047036459 247 6708665 A sedative which affects the nervous system.
SGTC_3207 9114163 49.47 µM 0.773308412701147 0.212036062872896 no 724 0.21966993908042 265 849233
SGTC_2555 cholic acid 100 µM 0.772445334409472 0.212280248829009 no 725 0.219925356087356 220 6708657 Influences liver metabolism.
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.772060430703519 0.212389200472214 no 726 0.220039318353583 238 88881 An O-methylated flavonoid and antioxidant.
SGTC_26 0302-0163 425.158 µM 0.771940433274534 0.212423173873884 no 727 0.220074854111347 279 3100915
SGTC_2324 6149169 200 µM 0.771492717982693 0.212549958038102 no 728 0.220207468521802 236 2888231
SGTC_1351 1496-0003 46.5 µM 0.769300756620882 0.213171315967344 no 729 0.220857394086183 247 3891978
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.769036690512986 0.21324624254062 no 730 0.220935764829322 247 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_761 k216-0224 480 µM 0.768987329725091 0.213260249959206 no 731 0.220950416114727 263 1340404
SGTC_81 0411-0046 9.971 µM 0.768682689530491 0.213346711479782 no 732 0.221040851825456 256 12925265
SGTC_542 3381-0244 89.3 µM 0.768631010873418 0.213361380695812 no 733 0.22105619529066 260 1112843
SGTC_2385 9074692 200 µM 0.767010944011066 0.213821541925524 no 734 0.22153750434849 240 17046906
SGTC_2539 epi(13)torulosol 80 µM 0.765641252652514 0.214211037363699 no 735 0.22194489570924 254 6708597
SGTC_2891 9063876 19.48 µM 0.765426052356172 0.214272270792261 no 736 0.222008942235034 222 6472478
SGTC_3090 9117696 49.47 µM 0.763090432625673 0.214937506340495 no 737 0.222704732718664 233 7923821
SGTC_1178 0988-0033 191 µM 0.762658076289235 0.215060782318341 no 738 0.222833669601023 244 5392207
SGTC_597 k018-0003 82.8 µM 0.760679311422218 0.21562550301177 no 739 0.223424317414327 263 6786234
SGTC_110 0850-0284 111.64 µM 0.759697040404391 0.215906152877728 no 740 0.223717849124313 228 3906265
SGTC_2598 perillyl alcohol 100 µM 0.758466139516408 0.216258138734448 no 741 0.224085988137277 242 10819 An apoptosis inducer.
SGTC_2940 9060638 45.86 µM 0.757939431439433 0.216408856518075 no 742 0.224243621554216 233 4027022
SGTC_1275 0867-0008 21.1 µM 0.7578610851154 0.216431280551182 no 743 0.224267074453319 242 3422836
SGTC_770 0389-1121 67.2 µM 0.7570090319338 0.21667523929414 no 744 0.224522225692598 228 6753108
SGTC_3244 9134489 49.47 µM 0.755997508773237 0.216965063651302 no 745 0.224825344673029 259 16584271
SGTC_3150 9097574 49.47 µM 0.754057324528555 0.217521597106099 no 746 0.225407400530666 233 17217476
SGTC_2158 5657123 3.6195 µM 0.752062823760323 0.218094568996101 no 747 0.226006639648752 268 2858827
SGTC_2003 4023581 200 µM 0.75099569874624 0.218401485131455 no 748 0.226327622192054 235 16641307
SGTC_51 1013-0126 23.419 µM 0.750783759629332 0.218462470599272 no 749 0.226391402393645 242 1627850
SGTC_3205 9113483 49.47 µM 0.750495076079204 0.218545555047734 no 750 0.226478294118649 257 17018033
SGTC_166 k072-0058 166.424 µM 0.750370394488519 0.218581444605791 no 751 0.226515828225453 264 5846229
SGTC_1783 st039459 87.517 µM 0.74976931138391 0.218754513798889 no 752 0.226696827363713 272 729761
SGTC_1565 sinapyl alcohol 95.1 µM 0.748458420869314 0.21913223046262 no 753 0.227091847843274 257 5280507 A phenol propionate derived from cinnamic acid.
SGTC_83 0170-0301 39.027 µM 0.747251371337622 0.219480358015312 no 754 0.227455920052338 245 3089716
SGTC_1279 0874-0590 65.2 µM 0.742617812794311 0.220819678879083 no 755 0.228856550496016 250 3523074
SGTC_2890 9046729 58.44 µM 0.7409229429688 0.221310744132194 no 756 0.229370081797156 257 903329
SGTC_3011 9081274 71.4286 µM 0.740383092248086 0.221467289514053 no 757 0.229533787557682 256 6625322
SGTC_1881 5652484 16 µM 0.740182606997472 0.221525442146569 no 758 0.229594599901904 258 2255129
SGTC_2662 daunorubicin 22.37 µM 0.738946525693778 0.221884171897835 no 759 0.229969734533676 247 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_187 1488-2104 32.728 µM 0.737849451624399 0.222202837329544 no 760 0.230302969427144 254 2852859
SGTC_675 1309-0189 238 µM 0.735919099013445 0.222764177484066 no 761 0.2308899666821 238 4246530
SGTC_471 1-acyl-paf 4 µM 0.734180174111965 0.22327054225951 no 762 0.231419467523086 241 16759367
SGTC_1799 st045822 46.1415 µM 0.733114460353032 0.223581195379264 no 763 0.231744310624781 258 3674992
SGTC_1298 1079-1278 263 µM 0.731080385720448 0.224174805301239 no 764 0.232365027050846 259 2840950
SGTC_763 3453-1109 128 µM 0.729866078599624 0.224529606299628 no 765 0.232736024352299 252 1560353
SGTC_861 0443-0273 110 µM 0.728708225291636 0.224868208941588 no 766 0.233090080156154 262 6149169
SGTC_2065 5221596 34.26 µM 0.72797030293794 0.225084157918012 no 767 0.233315882723486 255 788581
SGTC_1769 st044406 64.4 µM 0.726950354387347 0.225382833692369 no 768 0.233628184404171 279 670903
SGTC_1028 k015-0029 4.8 µM 0.725900809366924 0.225690410445325 no 769 0.233949790154485 268 4588309
SGTC_482 fipronil 114 µM 0.725002828089764 0.225953758750269 no 770 0.234225147722066 256 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2611 pyromycin 23.93 µM 0.72484128548121 0.226001152303353 no 771 0.23427470228827 251 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1702 st027038 51 µM 0.722603228846626 0.226658333857347 no 772 0.234961841981159 254 5521182
SGTC_2337 9009472 200 µM 0.721677125160954 0.226930589532193 no 773 0.235246504527846 263 5742383
SGTC_3179 9107801 49.47 µM 0.717200936587757 0.228249095083554 no 774 0.236625060733766 241 4818259
SGTC_3309 9129340 25.759 µM 0.71611203049953 0.228570493118984 no 775 0.236961087919822 256 17158987
SGTC_2012 4023501 200 µM 0.713665625760347 0.229293492352517 no 776 0.237716983389469 281 3477460
SGTC_929 2805-0021 398 µM 0.711275786101594 0.230001010943459 no 777 0.238456676696627 283 3098024
SGTC_154 3389-1638 511.116 µM 0.7083137287509 0.230879629277424 no 778 0.239375226699936 289 5238686
SGTC_511 blebbistatin 171 µM 0.705483481304634 0.231720897610876 no 779 0.240254704132609 265 3476986 A myosin inhibitor.
SGTC_211 3455-0679 143.504 µM 0.705464421484981 0.231726568773119 no 780 0.240260632786307 239 748649
SGTC_2761 levamisole 97.89 µM 0.704999224602414 0.231865009955804 no 781 0.240405359353619 258 26879 An alkaline phosphatase inhibitor.
SGTC_543 3844-1095 191 µM 0.704722555848118 0.23194736758025 no 782 0.240491455786932 284 4230703
SGTC_296 1222-0039 74.9 µM 0.702880296509509 0.232496178989932 no 783 0.241065175613683 257 5984176
SGTC_3139 9095020 49.47 µM 0.702477251413818 0.232616342837108 no 784 0.241190791809002 232 25236292
SGTC_2765 myclobutanil 7.74 µM 0.701617373997907 0.232872822016841 no 785 0.241458906831264 289 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3080 9117754 49.47 µM 0.701384632580303 0.232942269764803 no 786 0.241531504853421 268 9550191
SGTC_2030 5175110 200 µM 0.699743195688945 0.233432384896257 no 787 0.242043847586288 291 2831986
SGTC_1939 st074455 53.6 µM 0.697193243002285 0.234194906268963 no 788 0.242840933512512 273 1644229
SGTC_48 0382-0018 55 µM 0.695163287710195 0.234802915544438 no 789 0.243476488325034 245 762596
SGTC_2461 5755302 26.15 µM 0.69048654229456 0.236207002638702 no 790 0.244944135057077 294 2788904
SGTC_1507 4075-3230 155 µM 0.689785266921357 0.236417942690798 no 791 0.245164617553769 269 659771
SGTC_1296 1068-0102 11.9 µM 0.688794888020634 0.236716020151573 no 792 0.245476176526169 265 767053
SGTC_3298 9116858 71.43 µM 0.685872499970928 0.237596784199557 no 793 0.246396756485379 295 2506942
SGTC_3193 9111931 49.47 µM 0.685346902991841 0.237755381852194 no 794 0.246562520611171 315 17087244
SGTC_2505 galangin 7.89 µM 0.685070606647496 0.237838776905403 no 795 0.246649683612776 280 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2368 9071271 200 µM 0.684268991406826 0.238080820725753 no 796 0.246902661941713 280 27209959
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.682037479812403 0.238755325217506 no 797 0.247607625890009 268 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.68120844349356 0.239006178718982 no 798 0.247869803057003 266 16623 A steroid.
SGTC_2563 tomatine 8.54 µM 0.678225862873242 0.239909851817234 no 799 0.24881424833521 305 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1520 flindersine 88 µM 0.678152354222935 0.239932147240466 no 800 0.248837549289672 282 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1121 fusaric acid 630.51 nM 0.677660581856743 0.240081332532004 no 801 0.248993462391227 257 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1983 st071813 46.9 µM 0.675293560798679 0.240800104918079 no 802 0.249744637079415 278 11838595
SGTC_662 k832-1615 104 µM 0.673613529658702 0.241310974746246 no 803 0.250278524619814 277 5878478
SGTC_1020 4335-0961 93.3 µM 0.673194455639034 0.241438499973898 no 804 0.250411794008211 295 669075
SGTC_1606 st000094 49.2 µM 0.672828164964626 0.241549993077779 no 805 0.250528308605341 256 1242210
SGTC_3039 9090270 49.47 µM 0.672790637354904 0.241561417468998 no 806 0.250540247507329 256 17173750
SGTC_1641 st009299 47.1 µM 0.67161795076936 0.241918561895598 no 807 0.250913473737638 266 4046054
SGTC_779 1360-0071 233 µM 0.670970580739631 0.242115842590572 no 808 0.251119635581207 278 7566
SGTC_1924 st058459 75.1 µM 0.670211327541883 0.242347329862393 no 809 0.251361541928192 280 688683
SGTC_884 0851-0618 334 µM 0.670095053979483 0.242382790875348 no 810 0.251398598826671 293 9642473
SGTC_2407 paclitaxel 400 µM 0.66854552529273 0.242855633094714 no 811 0.251892715997573 314 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_834 0312-0008 75.7 µM 0.668513110738856 0.24286552979711 no 812 0.251903057893986 289 6385573 YIL048W NEO1
SGTC_979 1426-2828 121 µM 0.666773840566164 0.243396877779712 no 813 0.252458302281607 273 747872
SGTC_449 xestospongin c 11.1929 µM 0.666503120424575 0.243479639387882 no 814 0.252544784915772 291 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2350 9023895 38.85 µM 0.665832926383823 0.243684589183488 no 815 0.252758948218785 284 2997209
SGTC_2543 pimpinellin 60.67 µM 0.665811722026425 0.243691075136807 no 816 0.252765725719997 274 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2339 9000433 200 µM 0.665205870078228 0.24387643148567 no 817 0.252959413237474 270 2988954
SGTC_1636 st007707 68.9 µM 0.664885389677232 0.24397451107762 no 818 0.253061900625017 303 403051
SGTC_3351 9150312 21.596 µM 0.664152743794623 0.244198809405827 no 819 0.253296277673642 285 4904905
SGTC_1090 efavirenz 20.7 µM 0.663911029947523 0.244272834085027 no 820 0.253373628160294 278 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2056 5235370 200 µM 0.662820353094777 0.244607003408826 no 821 0.25372280837625 274 5511916
SGTC_2935 9038016 29.96 µM 0.662533955351038 0.244694792780231 no 822 0.253814540489462 281 6463195
SGTC_2740 felodipine 17.08 µM 0.6618476276261 0.244905241530957 no 823 0.254034439496141 250 3333 L-type calcium channel blocker
SGTC_2277 7947813 106.88 µM 0.66168884084559 0.244953944210076 no 824 0.254085328922455 285 1246798
SGTC_2466 5983409 37.09 µM 0.66161804589226 0.244975659938374 no 825 0.254108019654125 281 2879657
SGTC_1432 4049-0298 68.4 µM 0.660067009334184 0.24545168656719 no 826 0.254605414276941 289 741646
SGTC_20 0481-0013 4.944 µM 0.659716148456428 0.245559437718341 no 827 0.254718000887961 287 182045
SGTC_856 0433-0016 11.3 µM 0.659505021861133 0.245624288007199 no 828 0.254785761178289 279 3911780
SGTC_2919 7978188 46.38 µM 0.659496826011473 0.245626805654827 no 829 0.254788391795815 261 2980291
SGTC_258 haloperidol 50.781 µM 0.659424084670989 0.24564915136014 no 830 0.254811740168477 301 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1911 st060208 74.3 µM 0.659256818709126 0.245700538605785 no 831 0.254865433117089 299 688783
SGTC_2318 6029776 164 µM 0.658245444661979 0.24601137464163 no 832 0.255190213771157 298 818325
SGTC_1183 1254-0324 198 µM 0.657768962743912 0.246157889831457 no 833 0.255343300481687 271 5799357
SGTC_1901 st060216 58.6 µM 0.65762363525443 0.246202586430801 no 834 0.255390001641479 278 688792
SGTC_5 0352-0601 109.883 µM 0.657199194841713 0.246333151291783 no 835 0.25552642161984 280 762456
SGTC_1271 0832-2808 169 µM 0.65701635650217 0.246389406811943 no 836 0.255585199672052 296 3663794
SGTC_593 1203-0218 61.7 µM 0.656818731340266 0.246450219669484 no 837 0.255648739266798 292 3666956
SGTC_2921 7974240 10.71 µM 0.656204509687524 0.24663927818104 no 838 0.255846273828476 282 2979074 YDR527W RBA50
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.655727287681977 0.246786221562535 no 839 0.255999804081286 291 616764
SGTC_1579 chlormadinone acetate 49.4 µM 0.654624166670925 0.247126067380526 no 840 0.256354880327751 302 45114258 A steroidal progestin.
SGTC_1704 st028805 70.8 µM 0.653826136275876 0.247372077863759 no 841 0.25661191291178 289 2876101
SGTC_821 1114-0266 29.2 µM 0.653724945344542 0.247403281550681 no 842 0.256644514446977 282 3123235
SGTC_2115 tiliquinol 12.7705 µM 0.652893725874874 0.247659679688224 no 843 0.25691239703212 298 71208 A bioactive hydroxyquinoline.
SGTC_1849 st056239 19.2 µM 0.652723827040598 0.247712104182215 no 844 0.256967169353619 282 5393181
SGTC_1967 st070177 51.4 µM 0.652489810679187 0.247784322674196 no 845 0.257042621955461 295 5729214
SGTC_3086 9117350 49.47 µM 0.651160935751625 0.248194632468287 no 846 0.257471302165578 258 2679265
SGTC_1060 3448-7350 82 µM 0.648871540504795 0.248902366107822 no 847 0.258210705653026 289 570178
SGTC_987 1497-1013 404 µM 0.648540179553375 0.249004890496796 no 848 0.258317816053924 289 1676435
SGTC_1329 1447-1697 50.6 µM 0.648509520761288 0.249014377583931 no 849 0.258327727484569 278 2840515
SGTC_2533 agelasine 13.65 µM 0.648415513809207 0.249043468387669 no 850 0.258358119453277 281 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_406 estrone 100 µM 0.647959185567435 0.249184706560538 no 851 0.258505674369613 286 5870 A steroid.
SGTC_99 0109-0120 622.8 µM 0.647679797042678 0.249271201135011 no 852 0.25859603690891 296 759414
SGTC_3142 9086498 49.47 µM 0.646975256227274 0.249489387465657 no 853 0.258823978919331 276 25236367
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.645690517322298 0.2498875140495 no 854 0.259239901490685 324 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1101 ebselen 5.29 µM 0.644934579490444 0.250121928435387 no 855 0.259484790834382 298 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_349 k015-0014 24 µM 0.644528499908776 0.250247900817571 no 856 0.259616391389617 290 2196908
SGTC_575 k072-0246 11.9 µM 0.643765261911139 0.250484760463646 no 857 0.259863831545078 281 6796779
SGTC_2741 miltefosine 3.04 µM 0.642856498624791 0.250766936596978 no 858 0.260158609285919 272 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_841 0251-0215 91.2 µM 0.641934011229067 0.251053546198822 no 859 0.260458014931116 297 3888614
SGTC_1795 st049545 62.3 µM 0.638752305226318 0.25204340552128 no 860 0.261492040050909 250 5291882
SGTC_2972 9093619 59.92 µM 0.635764841869649 0.252974705123532 no 861 0.26246485310652 256 25236256
SGTC_2055 5235184 200 µM 0.635490388772635 0.253060352735969 no 862 0.262554316596745 317 2836034
SGTC_2744 captopril 92.04 µM 0.633825310589427 0.25358029467339 no 863 0.263097416595593 256 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1987 st072290 61.9 µM 0.633329418868073 0.253735251581742 no 864 0.263259272898302 303 54697379
SGTC_1352 1496-0991 99 µM 0.633310428623584 0.253741186667068 no 865 0.263265472219509 297 3000039
SGTC_903 1134-0042 114 µM 0.633212640901731 0.253771749748529 no 866 0.263297395974607 298 701009
SGTC_1546 5-methoxyflavanone 78.7 µM 0.632294380852076 0.254058841768151 no 867 0.263597267331388 273 147795
SGTC_1780 st038448 24.544 µM 0.632278906916065 0.25406368112017 no 868 0.263602322065882 305 728868 YDL195W SEC31
SGTC_1763 st044482 94.5 µM 0.631746540312729 0.254230204042715 no 869 0.263776255693215 298 88505
SGTC_37 0566-0070 1.56 µM 0.6311537315256 0.25441570045012 no 870 0.263970005702834 294 1626686
SGTC_190 3970-0790 3.722 µM 0.630926117931504 0.254486942094932 no 871 0.26404441680852 292 2832352
SGTC_2834 9001755 58.44 µM 0.63037630370444 0.254659073651692 no 872 0.264224205358234 291 2989575
SGTC_1524 corynanthine 62.1 µM 0.628944981679764 0.255107466621261 no 873 0.264692538058688 313 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3186 9110464 49.47 µM 0.626565824568557 0.255853702347168 no 874 0.265471938103028 291 17018021
SGTC_1935 st074532 41.6 µM 0.625516885285654 0.25618306943439 no 875 0.265815934875737 292 2829742
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.621186795959329 0.257545054574393 no 876 0.267238363062549 315 7104
SGTC_1725 st036284 20.55 µM 0.618564994912768 0.258371539351386 no 877 0.268101484166707 295 707914
SGTC_1211 1056-0033 32.3 µM 0.61473975992596 0.259579849763493 no 878 0.269363298852325 280 6741922
SGTC_2768 sulfasalazine 50.2 µM 0.613622245363772 0.259933398740842 no 879 0.269732490042284 308 5384001 An antioxidant and salicylic acid derivative.
SGTC_2420 aureobasidin a 50 nM 0.612974566973961 0.260138418899973 no 880 0.269946578278651 280 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2147 5545932 89.7195 µM 0.612497647203434 0.260289439330862 no 881 0.270104277092629 317 797404
SGTC_304 1310-0298 97 µM 0.612351619605873 0.26033568916039 no 882 0.270152571952238 324 1550234
SGTC_3041 9091929 49.47 µM 0.611707199177288 0.260539840415552 no 883 0.270365748952869 301 25236887
SGTC_3183 9108214 49.47 µM 0.610939711122287 0.260783086774222 no 884 0.27061974689975 277 4974831
SGTC_2932 9016711 44.54 µM 0.610896471342045 0.260796794592674 no 885 0.270634060525312 310 7117328
SGTC_186 3455-3465 67.277 µM 0.609325561818241 0.261295053524685 no 886 0.271154333549915 297 755278
SGTC_41 0478-0632 82.643 µM 0.608940346076302 0.261417310346835 no 887 0.27128199010969 332 3750424
SGTC_1442 4112-3290 3 µM 0.608594995803036 0.261526939939405 no 888 0.271396461120688 307 704353
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.605975659445512 0.26235920191535 no 889 0.2722654582465 322 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_708 3448-5400 146 µM 0.605377824833637 0.262549346459588 no 890 0.272463990871898 306 3462195
SGTC_2986 9022445 71.43 µM 0.60501850842038 0.262663662921818 no 891 0.272583349474292 305 6459286
SGTC_2709 st078560 56 µM 0.604646869100481 0.26278192670123 no 892 0.272706828830541 325 17250903
SGTC_787 4152-0075 138 µM 0.603035963313838 0.263294866929425 no 893 0.273242382479844 293 9566539
SGTC_925 2064-1272 59.6 µM 0.60221588327313 0.263556190849926 no 894 0.273515222166232 308 6815817
SGTC_785 1270-0111 65.3 µM 0.60173172076674 0.263710534541761 no 895 0.273676365757507 300 6741994
SGTC_1031 k035-0009 16 µM 0.601403088680325 0.263815323745771 no 896 0.273785770981413 313 5180959
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.600540728824226 0.26409040086786 no 897 0.274072962837195 299 75037 A free radical scavenger.
SGTC_3 0833-0587 95.581 µM 0.600429045907982 0.264126036373393 no 898 0.274110167502605 304 5382644
SGTC_1282 0886-0010 32.4 µM 0.599265086510952 0.264497575367966 no 899 0.274498062983673 305 2836211 YNL267W PIK1
SGTC_2995 9067767 71.4286 µM 0.598726468658493 0.264669593608614 no 900 0.274677651787446 297 11673567
SGTC_673 1082-0474 110 µM 0.597873258191281 0.264942199613118 no 901 0.274962252257914 316 3098046
SGTC_220 paclitaxel 373.376 µM 0.596021947947393 0.265534194940912 no 902 0.275580282296128 296 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_395 anisomycin 6.25 µM 0.595955100477282 0.26555558336841 no 903 0.275602611016631 320 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2269 7935389 174.42 µM 0.59545274895122 0.265716343047745 no 904 0.275770437398336 321 97605
SGTC_232 clozapine 119 µM 0.593923798448671 0.266205932522218 no 905 0.276281540413629 297 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_967 1306-0166 352 µM 0.59115238039978 0.267094538574427 no 906 0.277209163009529 315 4437607
SGTC_2880 9042983 58.44 µM 0.588856637733242 0.267831760140774 no 907 0.277978724096498 324 6464714
SGTC_1232 0279-0259 161 µM 0.588741221874922 0.267868850163019 no 908 0.278017440413598 314 1560000
SGTC_814 3342-0569 96 µM 0.585592924064872 0.26888158341503 no 909 0.279074552284502 314 4346283
SGTC_3270 9137563 49.47 µM 0.585279940296734 0.268982367888879 no 910 0.279179750347363 301 17015724
SGTC_2532 xanthone 78.9 µM 0.583203543158958 0.26965147216628 no 911 0.279878143128077 297 7020 An insecticide.
SGTC_3107 9121808 49.47 µM 0.583055975122149 0.269699056636553 no 912 0.279927809627211 262 662681
SGTC_793 0488-0545 106 µM 0.577591281107853 0.271464146331861 no 913 0.28177004740247 318 292548
SGTC_3294 9122953 26.2835 µM 0.577092434326289 0.271625559423122 no 914 0.281938507455414 311 16459826
SGTC_3155 9099265 49.47 µM 0.575455673633518 0.272155505534844 no 915 0.282491580388924 333 25236499
SGTC_2786 7743617 45.45 µM 0.574432070055073 0.272487186242366 no 916 0.282837728174534 300 583674
SGTC_1350 1495-0454 146 µM 0.573750054773882 0.272708292648765 no 917 0.283068475491037 312 1069057
SGTC_1235 benzylparaben 21.5 µM 0.572886628909278 0.272988339221942 no 918 0.283360729268219 340 7180
SGTC_2514 salinomycin 42.74 µM 0.571803007412524 0.273340006456576 no 919 0.283727719813941 330 23682228 A polyether potassium ionophore.
SGTC_49 0717-0965 32.132 µM 0.570501080488268 0.273762816750066 no 920 0.284168944741829 337 5889349 YGL099W LSG1
SGTC_2140 5586273 200 µM 0.570192005355421 0.273863238649441 no 921 0.284273738925426 316 854421
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.569298763353506 0.274153565109022 no 922 0.284576702955487 325 688788
SGTC_2648 atorvastatin 78.68 µM 0.569196498962796 0.274186813344119 no 923 0.284611398162784 322 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1611 st001856 99.4 µM 0.567477746999169 0.274745912430484 no 924 0.285194820616673 349 647478
SGTC_1313 1220-0047 237 µM 0.56718942070919 0.274839758167112 no 925 0.28529274744567 308 3528706
SGTC_3018 9082602 49.47 µM 0.566768658332269 0.274976738143162 no 926 0.285435683462465 325 17332089
SGTC_1655 st012546 55.1 µM 0.565579872565678 0.275363931235493 no 927 0.285839706733684 327 720985 YLR208W SEC13
SGTC_1793 st048256 72.231 µM 0.565491750931832 0.275392643541655 no 928 0.285869666763453 317 672022
SGTC_2493 resveratrol 26.09 µM 0.564689493681165 0.27565410742279 no 929 0.286142490807666 287 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_523 1934-0222 13.7 µM 0.564602498185886 0.275682467481443 no 930 0.286172082843194 355 1361595
SGTC_1968 st069590 43.6 µM 0.563647436823404 0.275993906569088 no 931 0.286497048187497 315 6384066
SGTC_850 0388-0143 75.9 µM 0.56327624762936 0.276114995478522 no 932 0.286623394762806 322 67273
SGTC_1009 4106-0057 9.87 µM 0.561535459086934 0.276683221212803 no 933 0.287216282272113 321 2928005
SGTC_3230 9131665 49.47 µM 0.561209968347897 0.276789530992209 no 934 0.287327204112393 321 15943720
SGTC_25 0118-0223 35.662 µM 0.56018068277555 0.277125841525819 no 935 0.287678100867062 323 5333628
SGTC_1004 4084-0029 199 µM 0.559980618695308 0.277191234008898 no 936 0.287746328797241 325 716894 YLR208W SEC13
SGTC_2980 9014342 25.29 µM 0.557932943757634 0.277860966002858 no 937 0.288445087344603 318 2996599
SGTC_2973 9094665 17.96 µM 0.557678481362661 0.277944248037642 no 938 0.288531977168413 324 25237061 YIL048W NEO1
SGTC_1446 4239-0190 62 µM 0.557208724468339 0.278098024990846 no 939 0.288692414769708 335 1340085
SGTC_838 0109-0203 71.4 µM 0.556888688278969 0.278202813986084 no 940 0.288801741826907 292 759422
SGTC_32 0928-0142 34.1 µM 0.555717172931251 0.27858656575365 no 941 0.28920210749942 327 2244242
SGTC_2967 9089538 49.85 µM 0.554612786922555 0.27894856396067 no 942 0.289579770462363 324 728216
SGTC_669 0108-0021 26.2 µM 0.554411697203941 0.279014502232245 no 943 0.289648561310998 353 17201
SGTC_1791 st048313 56.1 µM 0.552594866127173 0.279610593155145 no 944 0.290270429108448 305 1204976
SGTC_2606 farnesol 9.78 µM 0.552418562974694 0.279668470005539 no 945 0.290330807700244 325 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2468 5987765 72.9 µM 0.547338773467513 0.28133855717989 no 946 0.292073005234281 314 26772094
SGTC_3322 9139058 2.11 µM 0.545986605569468 0.281783920565152 no 947 0.292537572239015 293 4908926 YPR165W RHO1
SGTC_3238 9133470 49.47 µM 0.545524439185968 0.281936222136637 no 948 0.292696438366035 314 3534688
SGTC_1826 st055655 41.6 µM 0.543594927104057 0.282572498486101 no 949 0.293360125713314 321 676168
SGTC_2886 9058944 51.95 µM 0.542494162761489 0.282935795761951 no 950 0.293739063794166 293 4949929
SGTC_2035 5154463 94.595 µM 0.540468495262932 0.283604934426691 no 951 0.29443699105414 349 2769623
SGTC_2520 obtusaquinone 4.71 µM 0.538899832786431 0.284123630972485 no 952 0.29497798630758 338 5967872
SGTC_3177 9107506 49.47 µM 0.538561092850226 0.284235698820785 no 953 0.295094869942991 320 8897194
SGTC_2678 equilin 100 µM 0.537536053202971 0.28457494896746 no 954 0.295448694034609 294 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_207 4185-0010 4.486 µM 0.537466689469717 0.284597912776597 no 955 0.295472644116902 325 3761753
SGTC_509 pifithrin 175 µM 0.536133153790786 0.285039569874188 no 956 0.295933264129416 346 4817 A p53 inhibitor.
SGTC_2390 9097792 176.6 µM 0.535401299253013 0.28528209345985 no 957 0.296186195949279 310 4497149
SGTC_1244 0416-0015 52.5 µM 0.534683179623406 0.28552016105587 no 958 0.296434477285313 331 96201
SGTC_101 0490-5701 117.494 µM 0.533819825144463 0.285806501350232 no 959 0.29673309806391 338 4661669
SGTC_2274 7947094 46.08 µM 0.533638106427041 0.28586678760399 no 960 0.296795969261082 317 2971028
SGTC_1467 k284-1082 293 µM 0.531355791516921 0.286624473379796 no 961 0.297586125209697 330 3334705
SGTC_3354 9151612 71.43 µM 0.531105427799511 0.286707647377424 no 962 0.29767286157332 319 27261949
SGTC_1019 4262-0212 3.4 µM 0.53001128905452 0.287071268342232 no 963 0.298052051855778 328 4677213
SGTC_1830 st055982 50.3 µM 0.529187814681516 0.287345081923004 no 964 0.29833758440584 357 455313 An antimicrobial agent.
SGTC_1736 st036774 51 µM 0.52801018807076 0.287736869272837 no 965 0.298746132368148 330 1272247
SGTC_1424 4048-1941 275 µM 0.527616614766019 0.287867864344182 no 966 0.29888272941232 343 X1424
SGTC_1434 4073-0095 163 µM 0.522218562419709 0.289667362310575 no 967 0.300759081591434 334 24133745
SGTC_2332 7982454 138.89 µM 0.520297467942323 0.290309050975016 no 968 0.301428130215047 348 2981748
SGTC_1219 1469-0211 33.1 µM 0.520011649691681 0.290404577546968 no 969 0.301527727728936 350 6822282
SGTC_1262 0737-0114 49.6 µM 0.518962473170392 0.290755360874225 no 970 0.301893455367638 333 765919
SGTC_1666 st014829 29 µM 0.518716513354714 0.290837624125249 no 971 0.301979222205507 337 3858230
SGTC_1091 telmisartan 47.6 µM 0.518471107607616 0.29091971290546 no 972 0.302064806744375 337 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_444 curcumin 90.4 µM 0.51493498802436 0.292103753241462 no 973 0.303299225267931 332 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2825 7998094 58.44 µM 0.514160497062339 0.292363384231238 no 974 0.303569891852747 333 2987815
SGTC_2525 harmine 47.85 µM 0.513609672422335 0.292548101298871 no 975 0.30376245786546 341 5280953 A monoamine oxidase inhibitor
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.512971044396962 0.292762330780389 no 976 0.303985787781709 331 756377
SGTC_2845 9003024 42.97 µM 0.51296535044553 0.292764241159244 no 977 0.30398777930086 312 2990173
SGTC_1506 4226-2149 212 µM 0.510069190749153 0.293736681650141 no 978 0.30500149436766 340 991114
SGTC_1131 3454-3128 32.3 µM 0.508532838158919 0.294253147188675 no 979 0.305539857915048 302 710982
SGTC_935 2996-0153 430 µM 0.507082559298828 0.294741062405525 no 980 0.306048445888607 343 23738523
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.506937302852325 0.29478995136836 no 981 0.30609940546547 332 390807
SGTC_1002 4049-0206 172 µM 0.506785914699012 0.294840908058181 no 982 0.306152520191236 343 4662749
SGTC_1969 st069479 40.1 µM 0.505871203670365 0.295148882736038 no 983 0.306473534383771 338 3895485
SGTC_1792 st045773 43.6 µM 0.505016317277156 0.295436848854961 no 984 0.306773687680515 303 2919270
SGTC_2809 7964133 12.99 µM 0.504922893940308 0.295468326079477 no 985 0.306806496766489 358 1253665
SGTC_1991 st073000 8.92 µM 0.503925049156156 0.295804627165833 no 986 0.307157023649176 358 4301969 YIL048W NEO1
SGTC_328 k915-0120 63.5 µM 0.503851316547207 0.295829484054362 no 987 0.307182931731342 315 6624543
SGTC_3084 9116877 49.47 µM 0.503638434261977 0.295901256750996 no 988 0.307257739472951 334 27241325
SGTC_2399 5884133 200 µM 0.503308031456438 0.296012667012411 no 989 0.307373860310074 334 722445
SGTC_1327 1436-0082 2.18 µM 0.50283539251091 0.296172072091484 no 990 0.307540003939948 338 15992205
SGTC_1893 st059353 36.1 µM 0.502633417433475 0.296240203440219 no 991 0.307611014942838 371 3112488
SGTC_2821 7996764 71.43 µM 0.502516535937352 0.29627963383549 no 992 0.307652111782745 285 2987135
SGTC_2480 5767542 37.17 µM 0.50220430240552 0.296384978747206 no 993 0.307761908417052 346 2867358
SGTC_3160 9100216 49.47 µM 0.50207038760278 0.29643016571236 no 994 0.307809004710706 336 17191039
SGTC_2397 5161689 200 µM 0.501147402695758 0.29674169499988 no 995 0.308133693963819 338 2259942
SGTC_153 4077-0274 519.67 µM 0.500834653549728 0.296847289241904 no 996 0.30824374749312 332 3121976
SGTC_1754 st042065 16.137 µM 0.497823417527852 0.297864858757539 no 997 0.309304254469389 336 1126236 YIL048W NEO1
SGTC_2075 5212009 200 µM 0.496904097598044 0.298175835833805 no 998 0.309628340911416 363 780898
SGTC_2506 ethyl hematommate 54.16 µM 0.496396134382623 0.298347727250006 no 999 0.309807475931601 343 3940691 An allergen.
SGTC_2224 6650123 117.647 µM 0.496387451043317 0.29835066602709 no 1000 0.309810538534663 346 2908370
SGTC_1378 2093-0007 380 nM 0.494532302289037 0.29897882182804 no 1001 0.310465149607087 368 3618014
SGTC_2621 lithochol-11-enic acid 100 µM 0.493667718302526 0.299271776146623 no 1002 0.310770433604968 368 6708711
SGTC_163 TUB2.036 7.546 µM 0.493607505105486 0.299292183544181 no 1003 0.310791699698876 332 15992207 YJR013W GPI14
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.493402861111015 0.299361546003822 no 1004 0.310863980578819 354 65057 A dermal irritant. YDR527W RBA50
SGTC_2011 4012611 177 µM 0.493273367681449 0.299405440541054 no 1005 0.31090972182173 342 2049887
SGTC_1050 3232-1156 69.3 µM 0.492184817003336 0.299774543145035 no 1006 0.311294348380961 333 700529
SGTC_27 0485-0001 32.618 µM 0.491764837681088 0.299917003579199 no 1007 0.311442798250617 344 2054479
SGTC_10 0279-0212 42.575 µM 0.490351563961461 0.300396622518131 no 1008 0.311942572454656 324 39851 YBR002C RER2
SGTC_1339 1486-1321 22.7 µM 0.490036758714013 0.300503504311173 no 1009 0.312053943846779 346 3469382
SGTC_2183 6420625 130.508 µM 0.489955483569518 0.300531101409111 no 1010 0.312082700052964 349 2897619
SGTC_1905 st060207 84.5 µM 0.489850667039599 0.300566693709673 no 1011 0.312119787199037 331 1948547
SGTC_975 1335-0046 28.5 µM 0.489488096753718 0.30068982551812 no 1012 0.312248089827522 351 16486740
SGTC_114 0364-0001 490.298 µM 0.48899621896819 0.300856907584481 no 1013 0.312422186859155 325 4003655
SGTC_303 1348-1668 34.2 µM 0.488991367581878 0.300858555721976 no 1014 0.312423904185282 338 5380509
SGTC_45 0kpi-0036 14.9 µM 0.488527416957834 0.301016190187373 no 1015 0.312588155345499 352 2795021
SGTC_1343 1487-0095 224 µM 0.488120777760254 0.301154382809843 no 1016 0.312732147317692 376 4560101 YGL055W OLE1
SGTC_1693 xanthone 101.9 µM 0.487657996951782 0.301311689413426 no 1017 0.312896053951394 367 7020 An insecticide.
SGTC_2946 9065502 71.43 µM 0.486262111214233 0.301786397272266 no 1018 0.313390669498259 327 16489101
SGTC_1115 galangin 695.678 nM 0.485544245001021 0.302030657488767 no 1019 0.313645167687312 368 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_671 0560-0003 407 µM 0.485360487112618 0.302093196976636 no 1020 0.313710327866462 364 3238678
SGTC_1409 3909-8004 61.9 µM 0.485237469312535 0.302135067653766 no 1021 0.313753952979786 336 2119279
SGTC_2911 7942208 15.64 µM 0.482018253081581 0.303231693697629 no 1022 0.314896489839178 315 1243384
SGTC_2941 9056145 11.23 µM 0.481795277632888 0.303307716145194 no 1023 0.314975692197076 351 2119517
SGTC_1136 pergolide 1.05886 µM 0.481490283777291 0.303411716182348 no 1024 0.315084041815961 347 47811 A dopamine receptor agonist.
SGTC_693 4161-2696 114 µM 0.480554095033674 0.303731047206667 no 1025 0.315416723913079 347 805759
SGTC_1922 5578187 25 µM 0.480528665324954 0.303739723292002 no 1026 0.31542576265126 308 1350412
SGTC_1746 st038117 42 µM 0.480448891662341 0.303766941116664 no 1027 0.31545411812648 330 2898218
SGTC_370 0180-0345 38.7 µM 0.480123036970939 0.303878130160627 no 1028 0.31556995416263 327 3989527
SGTC_1390 3413-2614 145 µM 0.480021898294727 0.303912644672052 no 1029 0.315605911001046 368 3421432
SGTC_1834 st055981 52.8 µM 0.478126639120509 0.304559742487595 no 1030 0.316280036402767 360 471719 YDL150W RPC53
SGTC_1105 epirubicin 18.1 µM 0.476552930436181 0.305097518716537 no 1031 0.316840253893174 347 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.474509984905915 0.305796273228046 no 1032 0.317568139703118 338 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1501 4491-0275 38.4 µM 0.471548047149355 0.306810609611987 no 1033 0.3186247084852 369 5104718
SGTC_2999 9069765 71.4286 µM 0.471133920658723 0.306952548319565 no 1034 0.318772551612326 328 2097066
SGTC_1862 st057513 3.81 µM 0.469556286913896 0.307493535281746 no 1035 0.319336030857775 342 5393163
SGTC_150 3970-0969 77.2 µM 0.464679810556148 0.309168374890405 no 1036 0.321080384284076 355 6615640
SGTC_3101 9120531 49.47 µM 0.463997324431348 0.30940309445387 no 1037 0.321324831279023 383 24824904
SGTC_2754 granisetron 64.02 µM 0.463465879206914 0.309585922141187 no 1038 0.321515233367715 375 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1003 4049-0218 100 µM 0.463425837967858 0.309599699030559 no 1039 0.321529580934047 350 295161
SGTC_2221 6807166 181.081 µM 0.463388515595428 0.309612540687166 no 1040 0.321542954516534 350 674925
SGTC_2899 9053889 58.44 µM 0.463263228745947 0.309655650329612 no 1041 0.32158784976384 346 6470052
SGTC_530 4358-1714 28 µM 0.462797343441255 0.309815978622236 no 1042 0.321754817803251 353 1564641
SGTC_2151 5563267 85.4165 µM 0.461722505317908 0.310186008004435 no 1043 0.322140164968692 390 5310824
SGTC_890 0929-0006 47.2 µM 0.46136990477854 0.310307438008204 no 1044 0.322266619753594 331 1378169
SGTC_422 cantharidin 155 µM 0.460991145847414 0.310437899585786 no 1045 0.322402478764121 342 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_577 r071-0003 38.6 µM 0.460011367679602 0.31077548978692 no 1046 0.322754030511174 363 4568517 YMR134W ERG29
SGTC_3117 9124945 49.47 µM 0.459708882676268 0.31087974555891 no 1047 0.322862596425834 340 17592065
SGTC_2642 cholecalciferol 100 µM 0.459057489280694 0.311104309131969 no 1048 0.323096441483903 353 9821465 A vitamin D precursor, similar to steriods.
SGTC_202 3594-0513 34.79 µM 0.458703337440867 0.311226430164117 no 1049 0.323223608536009 342 708429
SGTC_2798 7813637 45.45 µM 0.457634277429768 0.311595196672763 no 1050 0.323607606460718 377 956368
SGTC_3277 9138724 49.47 µM 0.455930775582634 0.312183201024181 no 1051 0.324219879027711 354 15943418
SGTC_2964 9083345 53.42 µM 0.455924866159859 0.312185241636714 no 1052 0.324222003821029 343 17741579
SGTC_545 4218-0007 221 µM 0.453745533524306 0.312938190429674 no 1053 0.325005994991997 366 2840508
SGTC_515 4092-1064 102 µM 0.452501789248778 0.313368248254492 no 1054 0.325453766275964 381 717353
SGTC_29 0299-0004 12.984 µM 0.45195630062517 0.313556945656316 no 1055 0.325650231974215 348 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2848 9016370 25.97 µM 0.450414752469056 0.31409046727291 no 1056 0.32620570479748 346 7894410
SGTC_1600 coumarin 106 71.1 µM 0.448891770215296 0.314617945152698 no 1057 0.32675486656831 385 100336 A hepatotoxic, DNA x-linker.
SGTC_2246 7293507 91.5585 µM 0.447781297662767 0.315002790927729 no 1058 0.32715552109584 358 887656
SGTC_2340 7987427 183.45 µM 0.445409957476826 0.315825275720881 no 1059 0.328011758779604 337 2239331
SGTC_1064 honokiol 6.76 µM 0.444612466237192 0.316102085969923 no 1060 0.328299918469714 355 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1259 0671-0132 43 µM 0.443591451542134 0.316456632014038 no 1061 0.328668993651458 333 X1259
SGTC_2077 5212015 200 µM 0.443014513429104 0.316657047674413 no 1062 0.328877618507682 355 780900
SGTC_1895 st058434 18.3 µM 0.442194505198663 0.316941993192445 no 1063 0.329174230969907 381 5393175
SGTC_3076 9116187 49.47 µM 0.441987592303365 0.317013910737541 no 1064 0.329249092274297 386 27241210
SGTC_1994 st072947 40.9 µM 0.441191952767005 0.317290518745157 no 1065 0.329537019258658 377 5286565 YDL195W SEC31
SGTC_2512 diallyl trisulfide 49.23 µM 0.440698154796735 0.317462241394934 no 1066 0.329715766304532 385 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_974 1326-0144 138 µM 0.44042668385795 0.317556664576716 no 1067 0.329814051060238 372 5411856
SGTC_3044 9093193 49.47 µM 0.43927728130252 0.31795658191965 no 1068 0.330230316905994 366 25236277
SGTC_2827 7993847 71.43 µM 0.43773750174476 0.318492657878635 no 1069 0.330788290457009 366 2985692
SGTC_2460 5552655 174.22 µM 0.437663509517829 0.318518427937371 no 1070 0.330815112676956 342 5401989
SGTC_3124 9127567 49.47 µM 0.437424172642774 0.318601790345255 no 1071 0.330901878364349 356 17592030
SGTC_532 1548-0774 215 µM 0.436252040609548 0.319010183201449 no 1072 0.331326937063442 385 5932993
SGTC_3235 9132602 49.47 µM 0.43615010911013 0.31904570844926 no 1073 0.331363911500774 361 4912240
SGTC_2871 9038510 12.99 µM 0.435418463751553 0.319300750841723 no 1074 0.331629355366638 380 4945164
SGTC_1421 4029-0249 71.4 µM 0.434625880646308 0.319577131881184 no 1075 0.33191700312356 367 2894095
SGTC_1400 3771-8998 51.5 µM 0.43423817273413 0.31971236572678 no 1076 0.332057747895392 373 670767
SGTC_864 0469-0573 172 µM 0.43394196138549 0.319815701412938 no 1077 0.33216529377955 368 689425
SGTC_2708 st078559 56 µM 0.433504962938164 0.319968177334044 no 1078 0.332323980680048 354 17250902
SGTC_1615 st002656 86.5 µM 0.430249239389616 0.321105108700646 no 1079 0.333507173698178 345 1584458
SGTC_1634 st006576 41 µM 0.427835318714386 0.321949158768497 no 1080 0.334385510543619 385 3915356
SGTC_2807 7945238 51.95 µM 0.427813572263216 0.321956766804591 no 1081 0.334393427407623 393 17148797
SGTC_2592 piperlongumine 83.33 µM 0.424484668379405 0.323122268438724 no 1082 0.335606192118589 373 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_538 2922-0838 53.3 µM 0.421748010184756 0.324081718439115 no 1083 0.336604478619679 346 777039
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.420694245111215 0.324451472123455 no 1084 0.336989182010313 367 1377
SGTC_1093 fluphenazine 7.97 µM 0.419751321238368 0.324782479738321 no 1085 0.33733356466011 385 6602611 An atypical antipsychotic.
SGTC_876 0720-0963 56.8 µM 0.416626465190862 0.325880429405801 no 1086 0.33847582422278 392 765861
SGTC_2437 5741531 144.16 µM 0.415427997820295 0.326301924600596 no 1087 0.338914307167696 371 2262990
SGTC_263 alizarin 107.927 µM 0.414024887207057 0.326795673841024 no 1088 0.339427940323159 379 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2793 7325131 81.82 µM 0.413926526525173 0.326830297979223 no 1089 0.339463958174041 373 4176441
SGTC_2565 isoliquiritigenin 100 µM 0.413885134616777 0.326844868872574 no 1090 0.339479115558872 328 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_773 4358-1457 44.6 µM 0.413169726876073 0.327096750375991 no 1091 0.339741133146013 389 1186886
SGTC_2953 9074162 66.49 µM 0.412464337791493 0.327345181633406 no 1092 0.339999557248154 389 16451992
SGTC_1539 benzyladenosine 56 µM 0.411963315219601 0.327521683436064 no 1093 0.340183155965583 328 92208 A nucleotide analog.
SGTC_687 k029-0044 34.9 µM 0.411367317926097 0.327731693442242 no 1094 0.340401607332784 397 5829338
SGTC_2335 9018011 154.17 µM 0.411186414908775 0.327795448550045 no 1095 0.340467924460936 401 6458208
SGTC_2259 7964009 200 µM 0.409767408811508 0.328295718607822 no 1096 0.340988288022158 338 313134
SGTC_374 0880-0231 82.3 µM 0.409344401259284 0.328444909405164 no 1097 0.341143467671497 381 6833587
SGTC_3269 9137823 49.47 µM 0.407579125624196 0.329067800648605 no 1098 0.341791346040697 363 17682936
SGTC_175 3793-3120 23.7 µM 0.40703694685338 0.329259208057675 no 1099 0.341990426153557 392 5322297
SGTC_2458 5808907 16.39 µM 0.404247074531906 0.330244833987589 no 1100 0.343015520144949 410 2731747
SGTC_1140 3229-1848 2.98 µM 0.404149294851309 0.330279399713331 no 1101 0.34305146874604 392 2849525
SGTC_149 3970-0822 46.1 µM 0.402804640289177 0.330754890274367 no 1102 0.343545973616346 373 3114250 YBL034C STU1
SGTC_2545 solidagenone 89.61 µM 0.402190165119388 0.330972269161509 no 1103 0.343772039820482 366 6708572 An anti ulcer agent
SGTC_3271 9137798 49.47 µM 0.399678310463521 0.331861463702609 no 1104 0.344696734660718 362 6498326
SGTC_2978 9011784 42.97 µM 0.399477460014037 0.331932605595953 no 1105 0.344770714367351 375 2994934
SGTC_1423 4048-0112 5.59 µM 0.398751943947518 0.332189636249204 no 1106 0.345037994793706 384 X1423
SGTC_2046 4110841 106 µM 0.398682124773897 0.332214375454523 no 1107 0.345063720287989 386 44119630 YMR134W ERG29
SGTC_596 1155-0152 116 µM 0.398118265340496 0.332414195990815 no 1108 0.345271505536406 374 280313
SGTC_2204 7233102 200 µM 0.39712162657365 0.332767501382113 no 1109 0.345638886370623 395 2172480
SGTC_1175 0741-0056 27.6 µM 0.393564817335946 0.334029588666761 no 1110 0.346951180372098 379 765927
SGTC_2220 6782180 200 µM 0.390291606482848 0.335192706016396 no 1111 0.34816046460645 384 833803
SGTC_136 0097-0015 404.482 µM 0.389346444550315 0.335528858918055 no 1112 0.348509941787368 356 4861337
SGTC_2124 5246320 200 µM 0.388411863346779 0.335861378211219 no 1113 0.348855633182684 395 579342
SGTC_2273 7815444 169.05 µM 0.386135879610061 0.336671699003884 no 1114 0.349698019238056 423 2824616
SGTC_294 k038-0071 157 µM 0.386088715208461 0.336688499032493 no 1115 0.349715483550647 375 24152826
SGTC_713 1488-1073 324 µM 0.386076927476452 0.336692697890729 no 1116 0.349719848431203 405 3312542
SGTC_1955 wogonin 32.4 µM 0.384531342941992 0.337243420191436 no 1117 0.350292334957883 344 5281703 A flavanone.
SGTC_1182 1222-0449 220 µM 0.384126259626913 0.337387817136255 no 1118 0.350442434683316 373 658318
SGTC_413 propylparaben 100 µM 0.382629545828122 0.337921546834704 no 1119 0.350997230008344 363 7175 A pharmaceutical preservative.
SGTC_112 phenothiazine 287.218 µM 0.382037267690007 0.338132843929189 no 1120 0.351216860903881 409 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1878 temozolomide 1 mM 0.381891272187179 0.338184936122767 no 1121 0.351271007165468 395 5394 DNA alkylating agent.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.379585088903892 0.339008208483002 no 1122 0.352126715574939 381 4330530
SGTC_1234 0326-0494 15.5 µM 0.378599212027826 0.339360386543546 no 1123 0.352492753693666 406 1547813
SGTC_1419 3993-2473 62.6 µM 0.378256772642654 0.339482746684481 no 1124 0.352619927188387 382 704026
SGTC_2652 actinonin 100 µM 0.377798669947537 0.339646461999288 no 1125 0.352790080925508 392 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2616 abietic acid 100 µM 0.377203221658688 0.339859306678773 no 1126 0.353011293147353 388 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1444 4112-3581 28 µM 0.376877877083732 0.3399756235964 no 1127 0.353132181392669 373 2877249
SGTC_1673 st016611 27.3 µM 0.376542931976688 0.340095388804018 no 1128 0.353256652392685 405 5226799
SGTC_2104 5389443 200 µM 0.375868531844135 0.340336580759856 no 1129 0.353507317966979 387 2244536
SGTC_649 1123-0311 367 µM 0.374303138032418 0.340896678699716 no 1130 0.354089398840182 387 693629 YIL048W NEO1
SGTC_2081 5214970 32.255 µM 0.372271077106699 0.341624273404267 no 1131 0.354845515349951 378 2063512
SGTC_369 0957-0393 4.5 µM 0.372243494227332 0.341634153718505 no 1132 0.354855782700293 372 6997992
SGTC_1155 4088-0394 48.2 µM 0.37183313644959 0.341781158573482 no 1133 0.355008545228823 384 2326248
SGTC_2699 st077704 54.6 µM 0.370463630229117 0.342271938321961 no 1134 0.355518535357006 369 645852
SGTC_2685 mycophenolic acid 18.85 µM 0.366811025003178 0.343582196699169 no 1135 0.356879991636095 379 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1013 4112-3890 241 µM 0.366235756698681 0.343788728195006 no 1136 0.357094581437499 366 705171
SGTC_2142 5622915 118.518 µM 0.366041287794475 0.343858556519686 no 1137 0.357167133545259 373 5322196
SGTC_2763 lisinopril 49.32 µM 0.365017052751175 0.344226418428889 no 1138 0.357549338484726 409 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_942 3253-1115 227 µM 0.364502706737281 0.344411205397224 no 1139 0.357741326469363 411 46497897
SGTC_1355 1499-0035 1.68 µM 0.36231509224905 0.345197555103913 no 1140 0.358558290635786 389 1548538
SGTC_2219 9098279 200 µM 0.361959576426244 0.345325410431254 no 1141 0.358691119225068 382 902349
SGTC_1514 1189-1591 158 µM 0.361766319632065 0.345394919416532 no 1142 0.358763331418315 417 767698 YMR146C TIF34
SGTC_221 trifluoperazine 10.304 µM 0.361627758086565 0.345444759282563 no 1143 0.358815109332482 408 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_424 splitomicin 100 mM 0.361289737083023 0.3455663549176 no 1144 0.358941432479634 389 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1527 coumarin 137 µM 0.360671334436561 0.345788852933344 no 1145 0.359172578066028 435 323 A hepatotoxic, DNA x-linker.
SGTC_3045 9092950 49.47 µM 0.358458733116059 0.346585371041865 no 1146 0.360000022497617 384 44120432
SGTC_468 gf-109203x 121 µM 0.354901298345711 0.347867439820589 no 1147 0.361331767887039 391 2396 A protein kinase C inhibitor.
SGTC_1945 st075991 56.6 µM 0.353820435731645 0.348257318970408 no 1148 0.361736728710498 346 1084980
SGTC_714 4296-0578 26.1 µM 0.352637764046115 0.348684105567365 no 1149 0.362180011233283 389 1589775
SGTC_1231 0242-0792 125 µM 0.350098173079132 0.349601205650019 no 1150 0.363132510957058 414 3707635
SGTC_968 1309-0633 340 µM 0.349828659573876 0.349698584337059 no 1151 0.363233644592868 399 3761976
SGTC_3356 9151811 4.48 µM 0.349062194302981 0.349975572107332 no 1152 0.363521309067031 398 1859254 YPR165W RHO1
SGTC_2453 5731132 22.18 µM 0.346463854907312 0.350915162051375 no 1153 0.364497071828745 401 1362040
SGTC_3262 9137218 49.47 µM 0.346301737141947 0.350973816030456 no 1154 0.364557981621538 373 17650664
SGTC_2917 7979103 53.79 µM 0.345810471984929 0.351151576751706 no 1155 0.364742577327572 389 2980565
SGTC_3063 1327-0034 4 µM 0.344636162001549 0.351576624200147 no 1156 0.365183958064836 414 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_920 mycophenolic acid 780.421 nM 0.344374393799329 0.35167139784805 no 1157 0.365282371655285 377 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1885 st057546 99.9 µM 0.343458886551975 0.352002931364834 no 1158 0.365626632757892 383 702008
SGTC_2441 5730946 39.09 µM 0.343434181099407 0.352011879534584 no 1159 0.365635924329188 368 1774275
SGTC_587 k089-0003 57 µM 0.342425995023263 0.352377108467545 no 1160 0.36601516421074 414 9659696
SGTC_2603 homopterocarpin 100 µM 0.342269685050945 0.352433746052824 no 1161 0.366073973597558 388 101795 A weak amylase inhibitor.
SGTC_1267 0828-0272 9.49 µM 0.34173954735695 0.352625861286524 no 1162 0.366273453731174 395 745334
SGTC_40 0327-0103 19.753 µM 0.339409736220432 0.353470600614304 no 1163 0.367150542503116 387 409036
SGTC_1369 1866-0067 208 µM 0.339102113919009 0.353582191900615 no 1164 0.367266403006258 401 3531355
SGTC_1971 st069429 63.5 µM 0.338708962590015 0.353724827520725 no 1165 0.367414494099303 397 1246522 YGL099W LSG1
SGTC_3114 9122766 49.47 µM 0.33868773332074 0.353732530101383 no 1166 0.367422491239777 369 17176985
SGTC_2064 5220758 200 µM 0.337360492632822 0.354214209426314 no 1167 0.367922581522052 372 788518
SGTC_2379 9035213 200 µM 0.336389278637291 0.354566828208554 no 1168 0.368288666658071 423 646551
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.336110124666704 0.35466820375492 no 1169 0.36839391187519 393 688662
SGTC_3237 9133362 49.47 µM 0.335505930252004 0.354887653891875 no 1170 0.368621736003089 431 43845137
SGTC_510 ag-490 170 µM 0.334862494482357 0.355121409874325 no 1171 0.368864407686172 383 5328779
SGTC_1729 st035615 45.989 µM 0.334468314277961 0.355264639893275 no 1172 0.369013098514258 379 17385451
SGTC_847 0342-0274 5.54 µM 0.334026505796707 0.355425200511317 no 1173 0.369179778760161 414 18097
SGTC_3352 9151559 45.5865 µM 0.333227848188379 0.355715511202221 no 1174 0.369481149206039 372 17159339
SGTC_2028 5153890 36.43 µM 0.332428437288851 0.356006179542809 no 1175 0.36978288423287 400 2830968 YPR165W RHO1
SGTC_2624 nerol 100 µM 0.331842031517257 0.356219451779936 no 1176 0.370004272171271 406 637566 A natural product oil.
SGTC_694 1315-0438 43.2 µM 0.331403628087844 0.356378925850867 no 1177 0.370169812388088 404 6793154
SGTC_2636 apigenin dimethyl ether 100 µM 0.330740816475203 0.356620078555624 no 1178 0.370420134327808 403 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_873 0591-4978 488 µM 0.327258672855255 0.357887936844175 no 1179 0.371736123608047 435 3305145
SGTC_39 0986-0283 58.349 µM 0.326365152213524 0.358213523786688 no 1180 0.372074049920234 382 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_96 0929-0093 37.281 µM 0.326004156162874 0.358345095170999 no 1181 0.372210605302862 376 6991579
SGTC_222 nsc-310342 10.666 µM 0.325761241423652 0.3584336392047 no 1182 0.372302502654611 432 432556
SGTC_2859 9028643 45.46 µM 0.32492441100163 0.358738727696113 no 1183 0.372619140574104 402 17151580
SGTC_2958 9077254 16.72 µM 0.324818892420796 0.358777203668473 no 1184 0.37265907256304 380 16457351
SGTC_2647 atorvastatin 60.16 µM 0.324432456577432 0.358918124683756 no 1185 0.372805325330293 409 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1483 3453-0561 55.9 µM 0.322468672331217 0.359634551513481 no 1186 0.373548833547358 409 4546991
SGTC_1845 st056753 3.01 µM 0.321864601934194 0.359855027570319 no 1187 0.373777635438428 375 5375839
SGTC_224 benfluorex 43.875 µM 0.3217347513921 0.359902427039316 no 1188 0.373826824342107 430 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2345 9052315 157.45 µM 0.320785110599295 0.360249140790219 no 1189 0.374186621802001 388 6469265
SGTC_3299 9121982 43.1275 µM 0.320691176148311 0.360283442501304 no 1190 0.374222217407786 388 17594604 YPL160W CDC60
SGTC_235 0330-0087 5 mM 0.319501955370938 0.360717803212912 no 1191 0.374672954430345 400 46494818 YHR062C RPP1
SGTC_1124 fisetin 1.16336 µM 0.318935680607416 0.360924697241411 no 1192 0.374887643444719 391 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_690 glyoxal 20.3 µM 0.31876731633433 0.360986218629222 no 1193 0.374951482059264 396 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3197 9113331 49.47 µM 0.318296873206736 0.361158140633233 no 1194 0.375129877950021 364 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_937 3122-0005 46.7 µM 0.318082631453642 0.361236443924868 no 1195 0.375211129034665 427 759535
SGTC_2676 harmalol 100 µM 0.31789723636357 0.361304208732508 no 1196 0.375281444505007 398 5459187 A monoamine oxidase inhibitor
SGTC_1429 4049-0205 9.46 µM 0.317343937209532 0.361506474102391 no 1197 0.375491320920055 387 22774478
SGTC_1796 st049173 110.4 µM 0.316914575964146 0.36166345911008 no 1198 0.375654210835231 426 94134
SGTC_1648 st011736 69.8 µM 0.316258041341745 0.361903549298476 no 1199 0.375903328027002 398 2855514
SGTC_1671 st016596 74.5 µM 0.315990098671104 0.362001549712144 no 1200 0.37600501175522 405 2829167
SGTC_2553 4-methylesculetin 85.09 µM 0.31567409160437 0.362117141375539 no 1201 0.376124946893619 391 5319502
SGTC_958 1222-0007 33 µM 0.315400189882943 0.362217341574276 no 1202 0.376228911340264 414 7312461
SGTC_3278 9139605 49.47 µM 0.31412202119635 0.362685052842969 no 1203 0.376714182461475 402 7958859
SGTC_726 3448-4391 34.2 µM 0.31407829625224 0.362701056433491 no 1204 0.376730786579768 414 1356692
SGTC_414 piperonyl butoxide 100 µM 0.31370233930288 0.362838668815279 no 1205 0.376873561946927 416 5794 A potent inhibitor of cytochrome P450.
SGTC_367 0335-0881 7.1 µM 0.31225828071709 0.363367405444219 no 1206 0.377422121551263 431 23828853
SGTC_340 k038-0059 454 µM 0.310277121496953 0.364093223031238 no 1207 0.378175113808588 409 23733424
SGTC_1569 carminic acid 40.6 µM 0.309634197094004 0.364328869804247 no 1208 0.378419573966889 414 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1804 st050076 49.1 µM 0.309479180467627 0.364385694687247 no 1209 0.378478523468483 402 3895976
SGTC_1169 aniline yellow 25.8 µM 0.309429154604405 0.3644040334456 no 1210 0.378497547836067 435 6051 A DNA damaging agent.
SGTC_2478 5763493 32.33 µM 0.308978678323578 0.364569185516007 no 1211 0.378668873010063 418 1365576 YLR208W SEC13
SGTC_3314 9135860 59.4275 µM 0.305324412625998 0.365909826579987 no 1212 0.38005954224662 422 25252478
SGTC_2354 9060492 162 µM 0.305016527858653 0.366022855404705 no 1213 0.380176782178667 417 6471895
SGTC_1305 1181-0477 144 µM 0.304739146448455 0.366124695975806 no 1214 0.380282416117204 393 6252086
SGTC_586 0957-0265 8.15 µM 0.304639605752436 0.366161244637409 no 1215 0.380320325938827 448 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1272 0839-0021 27 µM 0.301581685409248 0.367284620766213 no 1216 0.381485485616195 429 5027250
SGTC_2927 9011802 47.9 µM 0.301092112311052 0.367464579134593 no 1217 0.381672127790543 391 43912568
SGTC_274 sirtinol 40.1 µM 0.300009753353352 0.367862538317628 no 1218 0.382084858006361 365 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.298557311409951 0.368396791628315 no 1219 0.382638920557296 397 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_470 aa-861 153 µM 0.298504730800647 0.368416137191726 no 1220 0.38265898297881 379 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2249 haloperidol 116.36 µM 0.298123322665539 0.368556475621857 no 1221 0.382804520779952 430 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2479 5617353 43.85 µM 0.298058874688248 0.368580190870189 no 1222 0.382829114488492 432 2731746
SGTC_3181 9108277 49.47 µM 0.296107939255597 0.369298322992715 no 1223 0.383573825539716 430 17097298
SGTC_56 0957-0365 83.25 µM 0.295860469486567 0.369389448365185 no 1224 0.383668320506266 412 6752360
SGTC_2808 7946468 45.46 µM 0.295775092624473 0.369420888244877 no 1225 0.383700922795739 428 2970879
SGTC_1014 4130-3005 69.3 µM 0.294767081497112 0.369792152541698 no 1226 0.384085907424557 406 743608
SGTC_1563 conessine 56.1 µM 0.294025167081562 0.370065487360742 no 1227 0.384369336183516 427 441082 An anti-amoebic, histamine inhibitor.
SGTC_411 enrofloxacin 100 µM 0.292764103716106 0.370530236679755 no 1228 0.384851233851809 439 71188 A bacterial gyrase inhibitor.
SGTC_980 1473-0395 201 µM 0.292503239273841 0.370626398662183 no 1229 0.384950941773138 432 768876
SGTC_17 0960-0276 49.807 µM 0.29249615363239 0.370629010742021 no 1230 0.384953650161712 407 6821114
SGTC_3055 9094636 49.47 µM 0.291558607796568 0.370974684027235 no 1231 0.385312063567859 422 25236176
SGTC_2449 5812982 45.77 µM 0.291432226694441 0.371021288729377 no 1232 0.385360385166575 420 776185
SGTC_2883 9059145 45.46 µM 0.290231151807016 0.371464295306543 no 1233 0.385819702831164 446 16476510
SGTC_1794 st048918 76.9 µM 0.290178728594936 0.371483635059706 no 1234 0.385839754281456 421 672303
SGTC_604 1000-0114 314 µM 0.289484539977446 0.371739762810162 no 1235 0.38610530449924 426 1572745
SGTC_1415 3966-0071 78.1 µM 0.287135045790831 0.372607052617911 no 1236 0.387004459407887 435 2893185
SGTC_1346 1488-2224 62.4 µM 0.287112840122739 0.372615252684738 no 1237 0.387012960451749 416 3722427
SGTC_2084 5306078 60.6385 µM 0.287086990252565 0.372624798548296 no 1238 0.387022856681633 439 679340
SGTC_2364 9055074 200 µM 0.282237252921073 0.374417092201966 no 1239 0.388880797615102 412 6470630
SGTC_3335 9143315 29.6265 µM 0.281259687723107 0.374778696470544 no 1240 0.389255613644827 397 4899691
SGTC_1779 st039427 55 µM 0.280711893304363 0.374981375419264 no 1241 0.38946569293177 430 1124498
SGTC_640 3381-0960 37.1 µM 0.279199954941598 0.375540957869438 no 1242 0.390045689107429 420 1745025
SGTC_2079 5212404 121 µM 0.278859886468453 0.375666856498804 no 1243 0.390176176890095 405 758462
SGTC_933 2914-0560 114 µM 0.278762183308892 0.375703030174506 no 1244 0.390213668889754 393 463887
SGTC_2190 6049624 200 µM 0.278017167897719 0.375978901029492 no 1245 0.390499590002732 427 2265554
SGTC_742 0kpi-0133 140 µM 0.27777450015516 0.376068771868267 no 1246 0.390592733530274 443 2728852
SGTC_1205 4161-2785 76 µM 0.277262479249809 0.376258418410928 no 1247 0.390789283884802 391 3498106
SGTC_2212 7123476 200 µM 0.276633381167704 0.376491469874075 no 1248 0.391030815059246 426 1085715
SGTC_3312 9133330 71.43 µM 0.276092499497238 0.376691877279345 no 1249 0.391238510701426 435 17617324
SGTC_3324 9138759 60.749 µM 0.275740288680337 0.37682239625564 no 1250 0.391373774433244 417 45595710
SGTC_1384 3089-0840 101 µM 0.274630839532144 0.377233617457625 no 1251 0.391799935250481 398 1069836
SGTC_2670 beta-carotene 100 µM 0.274532631009197 0.3772700255054 no 1252 0.391837665302213 396 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2239 6685329 187.64 µM 0.27333364475362 0.377714603807587 no 1253 0.39229837744143 369 805680
SGTC_382 3229-0966 23.2 µM 0.272907177815433 0.377872774784473 no 1254 0.392462284397416 439 5722370
SGTC_1876 myriocin 605 nM 0.271837787058006 0.378269487746405 no 1255 0.392873374499848 452 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2588 indole-3-carbinol 100 µM 0.271507883216895 0.378391898432435 no 1256 0.393000218707159 453 3712 Induces cell cycle arrest.
SGTC_2447 5741742 33.78 µM 0.271419878133292 0.378424554745602 no 1257 0.393034057563168 416 1776504
SGTC_1798 st045719 60.953 µM 0.26917191178945 0.379259008198411 no 1258 0.393898696992657 452 3980186
SGTC_2381 9035592 200 µM 0.269167557098059 0.379260625223497 no 1259 0.393900372454808 420 4749657
SGTC_1762 st045503 25.4615 µM 0.267753368977092 0.379785866480537 no 1260 0.394444583302087 426 4645554
SGTC_407 eburnamonine 100 µM 0.266925649392117 0.380093391428979 no 1261 0.394763203778454 406 3195
SGTC_2796 7949634 45.45 µM 0.266456370861713 0.380267777473946 no 1262 0.394943878064299 412 2971588
SGTC_912 3474-0017 2.18 µM 0.264932448651929 0.380834241616138 no 1263 0.395530750399134 442 3360550
SGTC_1690 st023502 41.2 µM 0.262331030984814 0.381801816379813 no 1264 0.396533120112788 451 24207482
SGTC_1843 st055809 45.5 µM 0.261062126896262 0.382274042756801 no 1265 0.397022298752481 402 16413835
SGTC_692 k241-0027 77.8 µM 0.26070646615872 0.382406434400675 no 1266 0.397159439595069 442 3600480
SGTC_290 2043-6722 48.1 µM 0.260292472851237 0.382560557153658 no 1267 0.397319089173972 434 773758 YLR208W SEC13
SGTC_314 1671-0008 2.74 µM 0.259835615464976 0.382730659074077 no 1268 0.39749528853415 435 3913060
SGTC_3331 9141060 1.957 µM 0.259222278112298 0.382959058821274 no 1269 0.397731871494527 415 4906567 YPR165W RHO1
SGTC_868 0527-0199 213 µM 0.25847052013727 0.383239060318758 no 1270 0.398021898820515 429 2849450
SGTC_2321 7390090 138.78 µM 0.258214520189382 0.383334424577894 no 1271 0.398120676165462 418 649046
SGTC_900 1112-0045 141 µM 0.254465033866944 0.384731978094358 no 1272 0.399568157056153 453 56211 YIL048W NEO1
SGTC_2282 7944268 200 µM 0.254198801528651 0.384831268619604 no 1273 0.399670988222497 429 2970414
SGTC_699 0375-0592 111 µM 0.254072916781068 0.384878219576552 no 1274 0.39971961312201 434 762578
SGTC_735 3076-0345 636 µM 0.253864443975701 0.384955976931879 no 1275 0.399800142335785 439 2888990
SGTC_1509 1326-1131 80 µM 0.253377004062462 0.385137803053958 no 1276 0.399988448043996 435 768313
SGTC_2101 5377231 179.231 µM 0.252924213431477 0.385306726838036 no 1277 0.400163389027309 446 2844213
SGTC_499 genistein 192 µM 0.249925360627093 0.38642606466554 no 1278 0.40132253525208 444 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_172 1112-0046 2.638 µM 0.249897966656261 0.386436293984556 no 1279 0.401333127861077 416 2802135 YIL048W NEO1
SGTC_2581 avocatin a 64 µM 0.249735485048021 0.386496968672814 no 1280 0.401395957196113 434 6710728 A skin care supplement.
SGTC_1806 st050005 60.3 µM 0.249733644169935 0.386497656118543 no 1281 0.401396669052187 432 5194765
SGTC_1844 rapamycin 4 nM 0.249261938927019 0.386673818439584 no 1282 0.401579085306873 428 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_93 0109-0045 59.227 µM 0.248873110483289 0.386819047279241 no 1283 0.401729467855634 448 88733
SGTC_2595 hexamethylquercetagetin 100 µM 0.248545206911701 0.386941532777247 no 1284 0.401856298528951 460 386331
SGTC_1768 st044301 37.178 µM 0.24839900726691 0.386996148000209 no 1285 0.401912850801577 460 3931349
SGTC_1376 2910-0861 41.3 µM 0.245935899244451 0.387916617102296 no 1286 0.402865926764484 417 1112859
SGTC_230 MPP+ 141.667 µM 0.245763513509406 0.387981061699063 no 1287 0.402932651453728 435 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1214 0358-0031 63.7 µM 0.24303109588355 0.389002958241152 no 1288 0.403990654219474 440 4301366
SGTC_226 1,3-diallylurea 8.28947 mM 0.242990313694125 0.389018216204182 no 1289 0.404006450583961 423 74537 YKL182W FAS1
SGTC_2697 mebhydrolin 72.4 µM 0.242676441247112 0.389135651971778 no 1290 0.404128029567517 429 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_426 0988-0037 14.6 µM 0.242269610083588 0.389287883429568 no 1291 0.404285630035043 464 5383008
SGTC_206 4546-0025 72.014 µM 0.241421350125268 0.389605347003995 no 1292 0.404614283521766 458 6620745 YIL048W NEO1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.241229269834657 0.389677243808226 no 1293 0.404688713290381 466 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_827 3253-0474 693 µM 0.240978991651181 0.389770930097075 no 1294 0.40478569950941 410 5402065
SGTC_862 0452-0056 10.2 µM 0.239917035988632 0.390168521685644 no 1295 0.40519728685159 428 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1250 0485-0349 40.2 µM 0.239801092269491 0.39021193747607 no 1296 0.40524223008324 431 6842794 YDL195W SEC31
SGTC_508 roscovitine 141 µM 0.239698304694881 0.390250428017854 no 1297 0.405282074647208 465 160355 A CDKinase inhibitor.
SGTC_2419 paclitaxel 166.5 µM 0.237297379709945 0.391149800196584 no 1298 0.406213047374057 434 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1726 st035556 14.5795 µM 0.235682893532972 0.391754904879447 no 1299 0.406839372495913 394 5919439
SGTC_3182 9108849 49.47 µM 0.233682432362604 0.392505035115546 no 1300 0.407615763567319 421 17133045
SGTC_14 0354-0009 295 µM 0.232844930618254 0.39281919920157 no 1301 0.407940911030768 478 1713507
SGTC_651 3253-0966 34.4 µM 0.230295545525009 0.393775954901364 no 1302 0.408931060877589 427 781462
SGTC_556 4058-0063 51.5 µM 0.23019660243204 0.393813100107178 no 1303 0.408969500920695 451 6615692
SGTC_1071 trifluoperazine 6.31 µM 0.230043226541151 0.393870682377966 no 1304 0.409029090194605 456 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1319 1306-0155 43.7 µM 0.228854875718143 0.394316906265118 no 1305 0.409490856873469 435 3122360
SGTC_1253 0550-0034 176 µM 0.228754869796246 0.394354464670371 no 1306 0.409529722687001 420 5969915
SGTC_2428 5615643 7.78 µM 0.227156335029525 0.394954946393194 no 1307 0.410151089883177 462 2253075
SGTC_1510 1123-0200 71.5 µM 0.226616331411748 0.395157852567041 no 1308 0.410361046010271 440 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1904 st060225 78 µM 0.226302472740085 0.395275797923533 no 1309 0.410483087653795 435 66595
SGTC_1958 st076513 41.9 µM 0.225654401266256 0.39551936788931 no 1310 0.410735112911779 460 732122 YGL099W LSG1
SGTC_3136 9095672 49.47 µM 0.223661032031361 0.396268807499881 no 1311 0.411510534862467 453 17217380
SGTC_2926 9010726 65.15 µM 0.223632536988558 0.396279523461731 no 1312 0.411521621966788 419 2994293
SGTC_1465 k213-0056 144 µM 0.223575624080195 0.396300926596393 no 1313 0.411543766358092 446 24048857 YMR208W ERG12
SGTC_1058 3448-5425 97.3 µM 0.222684518247184 0.396636083875658 no 1314 0.411890525742067 461 7279705
SGTC_683 panaxydol 45 µM 0.22147042774398 0.397092843060086 no 1315 0.412363080072247 437 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3247 9135149 49.47 µM 0.221039443607709 0.397255019789637 no 1316 0.412530860453338 463 8934436 YOR116C RPO31
SGTC_2569 tetrandrine 100 µM 0.220362591877106 0.397509750860101 no 1317 0.412794388346425 405 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_783 0848-0141 92.7 µM 0.219876528212533 0.397692706401519 no 1318 0.412983658382841 451 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_956 1185-0240 191 µM 0.218174956777469 0.398333359053319 no 1319 0.413646398339258 434 1416193
SGTC_1484 3473-2379 286 µM 0.217355036161071 0.398642162449669 no 1320 0.413965834731783 478 671917
SGTC_2250 alverine citrate 130 µM 0.217097787004291 0.398739062252107 no 1321 0.414066069278226 450 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1023 4482-3888 16 µM 0.214027250070266 0.399896142747331 no 1322 0.415262903516356 454 3303168
SGTC_820 1582-0060 59.9 µM 0.212775203958378 0.400368208399862 no 1323 0.415751152625014 435 3848840
SGTC_1356 1502-0781 85.8 µM 0.212550664683936 0.400452883060878 no 1324 0.415838727954963 425 567702
SGTC_752 1896-0090 130 µM 0.211159258348976 0.400977692150913 no 1325 0.416381500525718 446 772567
SGTC_2112 5488546 200 µM 0.209182018530899 0.401723772535051 no 1326 0.417153074524225 449 600757
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.206892083604248 0.402588291191679 no 1327 0.41804706956711 432 688761
SGTC_2667 digitoxin 100 µM 0.205856662837938 0.40297935009988 no 1328 0.41845143920044 448 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1698 5-fluorocytosine 1.055 µM 0.205585406903079 0.40308181441542 no 1329 0.418557388818101 458 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3146 9095609 49.47 µM 0.205004161281223 0.40330139674939 no 1330 0.418784436921371 434 17173999
SGTC_3144 9087057 49.47 µM 0.205002598748157 0.403301987082544 no 1331 0.418785047319746 482 17249618
SGTC_1683 st010134 710 nM 0.204578810065914 0.403462104790717 no 1332 0.418950606180117 444 3818134
SGTC_756 0508-1999 28.3 µM 0.204318701632525 0.403560388122143 no 1333 0.419052228217274 431 6753853
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.204245055764879 0.403588216704884 no 1334 0.419081001980043 434 4000243
SGTC_766 1391-0721 126 µM 0.203922054068855 0.403710275201303 no 1335 0.419207205266066 469 1020919 YIL115C NUP159
SGTC_959 1222-0044 107 µM 0.203559091315184 0.403847445695445 no 1336 0.419349032062983 453 6083612
SGTC_334 1502-1024 68.5 µM 0.203262223859495 0.40395964631804 no 1337 0.419465040077283 463 3296216
SGTC_2306 7482397 179.52 µM 0.202700728168554 0.4041718843975 no 1338 0.419684476998062 471 891448
SGTC_1292 0kpi-0043 232 µM 0.201081411088171 0.404784123001643 no 1339 0.420317458465282 471 3333905
SGTC_2780 5215298 71.43 µM 0.200807438036442 0.404887731054553 no 1340 0.420424573343111 452 2834131
SGTC_916 4466-0038 42 nM 0.199809342809161 0.405265235843793 no 1341 0.420814847083442 477 5722064 YGL116W CDC20
SGTC_225 nsc-122657 1.016 µM 0.199573778168353 0.405354345203534 no 1342 0.42090696859321 464 275685
SGTC_1191 1487-1166 10.6 µM 0.198631205282493 0.405710950591344 no 1343 0.421275620839959 470 3955771
SGTC_105 0111-0055 734.78 µM 0.197545339712266 0.406121865173288 no 1344 0.42170040222407 438 5179370
SGTC_1512 0259-0544 12.2 µM 0.19710763753348 0.406287530244198 no 1345 0.421871653394125 446 18476
SGTC_1088 bifonazole 369 nM 0.196870821431265 0.406377169319837 no 1346 0.421964313959928 468 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2729 fluphenazine 10.66 µM 0.195685704790034 0.40682583052311 no 1347 0.422428087008165 466 3372 An atypical antipsychotic.
SGTC_1737 st035557 69.7 µM 0.195256320309903 0.406988417025116 no 1348 0.422596145106438 489 5716916
SGTC_3093 9117344 49.47 µM 0.193718950241233 0.407570673703746 no 1349 0.423197976386188 427 24824913
SGTC_3137 9097352 49.47 µM 0.193631278658976 0.40760388421557 no 1350 0.42323230242636 476 44120435
SGTC_2907 7721985 69.9 µM 0.193619893515567 0.407608197023683 no 1351 0.42323676009244 434 3267881
SGTC_2470 5664817 21.68 µM 0.190708091164193 0.408711583623003 no 1352 0.424377149603914 467 2859561
SGTC_3231 9132313 49.47 µM 0.188916070682477 0.409391005059685 no 1353 0.4250792988957 461 4905967
SGTC_356 1634-0012 32.5 µM 0.188106839669559 0.409697903905177 no 1354 0.425396449764057 477 735457
SGTC_1291 0993-0025 5.79 µM 0.186024384193746 0.410487923954586 no 1355 0.426212819626029 458 4353356
SGTC_1192 1488-0095 21.4 µM 0.184703114261821 0.410989362051284 no 1356 0.426730951690002 459 915875
SGTC_697 0508-1955 564 µM 0.184568042368475 0.411040631696692 no 1357 0.426783926869773 464 6243113
SGTC_2644 guaiazulene 100 µM 0.184533312439565 0.411053814486048 no 1358 0.426797548157054 465 3515 A coloring agent.
SGTC_1477 0139-0234 16 µM 0.184049519024729 0.411237463270698 no 1359 0.42698730391888 458 620880
SGTC_373 0844-0104 25.9 µM 0.183435166805826 0.411470700425758 no 1360 0.427228292424398 456 5375804
SGTC_3257 9139206 32.98 µM 0.182584655604121 0.411793646325557 no 1361 0.427561962499719 470 4910041
SGTC_762 1165-0429 115 µM 0.181197453116724 0.412320506318586 no 1362 0.428106296816265 473 5967793
SGTC_3174 9107204 49.47 µM 0.179990846965513 0.412778904319457 no 1363 0.428579876956261 434 3938802
SGTC_38 0929-0051 58.268 µM 0.17840392109234 0.413381969444501 no 1364 0.42920288505898 467 1379719
SGTC_1371 2421-0008 32.7 µM 0.176997500918305 0.413916609524014 no 1365 0.429755176283006 468 2827552
SGTC_3261 9137475 49.47 µM 0.173657277001175 0.415187008470121 no 1366 0.431067407641571 480 17027690
SGTC_947 3447-0010 211 µM 0.173272905453642 0.415333255008995 no 1367 0.431218459928568 460 748350
SGTC_103 0844-0104 51.839 µM 0.173184101382974 0.415367045047684 no 1368 0.431253360035707 447 5375804
SGTC_2255 7941087 197.44 µM 0.172946191849063 0.415457572949911 no 1369 0.43134686141461 473 935561
SGTC_237 nikkomycin 200 µM 0.17203052474159 0.415806038914381 no 1370 0.431706765726156 474 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1815 st051655 58.2 µM 0.171285618102262 0.416089569187778 no 1371 0.431999594219827 467 5984156
SGTC_2144 5628481 200 µM 0.169770930650026 0.416666232022633 no 1372 0.432595144502105 472 2818399
SGTC_196 k015-0023 18.111 µM 0.169145136082739 0.416904533259374 no 1373 0.432841241458108 450 5211998
SGTC_2162 5663267 200 µM 0.167731082326557 0.417443114236311 no 1374 0.43339742121756 473 6456493
SGTC_2346 9031566 143.75 µM 0.167222948245541 0.417636688863633 no 1375 0.433597314279405 470 4771086
SGTC_2187 6125751 200 µM 0.16670078475512 0.417835628814723 no 1376 0.433802744016229 468 874498
SGTC_3148 9097893 49.47 µM 0.164813504564554 0.418554841879002 no 1377 0.434545387150831 451 17174100
SGTC_2540 epiandrosterone 100 µM 0.164233119168718 0.41877607257437 no 1378 0.434773814874275 480 441302 A steroid.
SGTC_858 0438-0351 2.77 µM 0.163936538492173 0.418889132807443 no 1379 0.434890551323755 480 2799119
SGTC_901 1112-0062 60.1 µM 0.163913198881432 0.418898030441059 no 1380 0.434899738216205 485 1908457
SGTC_3178 9107506 49.47 µM 0.163608857649908 0.419014056599065 no 1381 0.435019535638639 466 8897194
SGTC_1147 3809-1045 12.3 µM 0.162626201575697 0.419388729556351 no 1382 0.435406377873744 451 325925
SGTC_1266 0828-0227 32.9 µM 0.162569677516892 0.419410283612589 no 1383 0.435428631584911 448 3913820
SGTC_1217 1183-1422 255 µM 0.161926644633123 0.419655505357321 no 1384 0.435681810162808 460 2849664
SGTC_616 4092-0450 108 µM 0.161589590205466 0.419784054138808 no 1385 0.435814527693674 458 787165
SGTC_2850 9015429 58.44 µM 0.160159605713307 0.42032952923285 no 1386 0.436377674270702 484 6457570
SGTC_2334 9017922 200 µM 0.158807947385344 0.420845267125722 no 1387 0.436910093585063 477 3163164
SGTC_3037 9091026 49.47 µM 0.158691736610173 0.420889614791204 no 1388 0.436955874453298 478 25236398 YIL048W NEO1
SGTC_3025 9087895 49.47 µM 0.158368339317657 0.421013033026723 no 1389 0.437083280238423 464 17173641
SGTC_142 0335-0849 62.6745 µM 0.157986285072383 0.421158846539586 no 1390 0.437233802957735 463 3889043 YPR107C YTH1
SGTC_1450 4112-4260 37.6 µM 0.157793659378406 0.421232367503314 no 1391 0.437309697573246 482 1633175
SGTC_2456 5770359 74.46 µM 0.15598347777838 0.421923407594393 no 1392 0.438023022313485 495 3118787
SGTC_3071 9117417 49.47 µM 0.15286789834301 0.42311334764451 no 1393 0.439251225865464 486 45595590 YGL055W OLE1
SGTC_941 3237-0776 460 µM 0.152848588895773 0.423120724743039 no 1394 0.439258839747126 491 760008
SGTC_3073 9114972 49.47 µM 0.152331887920028 0.423318138325965 no 1395 0.439462587737568 495 41905075
SGTC_2646 retinol 96.75 µM 0.151902813687496 0.423482087393263 no 1396 0.439631794523992 474 445354 A vitamin A analog and teratogen.
SGTC_767 0929-0023 86 µM 0.151199849415419 0.423750718339618 no 1397 0.439909034539246 470 1204563
SGTC_3355 9151058 44.0485 µM 0.151108103997809 0.423785780573985 no 1398 0.439945219921983 493 17015728
SGTC_1043 0916-0009 19.3 µM 0.150453393281305 0.424036008070579 no 1399 0.440203459439349 498 3101130
SGTC_1883 5-benzylidenerhodanine 20 µM 0.150126749353021 0.42416086137224 no 1400 0.440332308105226 480 1273210
SGTC_595 3909-8003 73.7 µM 0.149136125430951 0.424539554635129 no 1401 0.440723110329689 483 699517
SGTC_2423 st077119 87.2 µM 0.148634090796996 0.424731497814594 no 1402 0.440921185613178 473 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_906 1165-0455 526 µM 0.147493698922151 0.425167570721526 no 1403 0.441371176435402 490 3252859
SGTC_1051 3253-3903 78 µM 0.146852833068594 0.425412670773816 no 1404 0.441624090969847 485 5509239
SGTC_2564 betulinic acid 100 µM 0.146460124399733 0.425562877010749 no 1405 0.441779083269417 446 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3026 9090633 49.47 µM 0.146156012219751 0.425679203603756 no 1406 0.441899114874529 463 25236842
SGTC_608 k048-0125 159 µM 0.145887050289175 0.425782090191451 no 1407 0.442005277292625 490 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_405 ebelactone b 50 µM 0.144216693786435 0.426421168140253 no 1408 0.442664679506157 478 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2186 6124449 200 µM 0.143238807210962 0.426795397072565 no 1409 0.443050791042489 492 3834182 YLR033W RSC58
SGTC_3127 9126946 49.47 µM 0.143097402079336 0.426849517083895 no 1410 0.443106628334247 486 27243249
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.142870285447489 0.426936444354763 no 1411 0.443196313282778 485 6728940
SGTC_2950 9072895 21.46 µM 0.142682386738329 0.427008363927805 no 1412 0.443270513862333 449 17332245
SGTC_717 1532-0246 73.2 µM 0.142647512046098 0.427021712732391 no 1413 0.443284285982047 459 9561992
SGTC_3308 9128332 17.569 µM 0.14170088932033 0.427384078461154 no 1414 0.443658136227317 482 17332805 YDL196W YDL196W
SGTC_911 3456-4043 236 µM 0.141393793671654 0.427501647382588 no 1415 0.443779428474107 465 914281
SGTC_1866 st057638 64 µM 0.140629555547491 0.42779425728581 no 1416 0.444081299155453 482 688802
SGTC_126 0417-1624 672.48 µM 0.136433536506751 0.429401523792584 no 1417 0.445739281621012 496 41912 YDL195W SEC31
SGTC_1931 st074438 57.1 µM 0.136372794671242 0.429424799346379 no 1418 0.445763289720045 501 2787313
SGTC_2450 5739737 12.93 µM 0.136001412242321 0.429567114038849 no 1419 0.445910082265556 502 2262825
SGTC_1087 pterostilbene 9.05 µM 0.13588950234056 0.429609999993751 no 1420 0.445954317205868 479 5281727 Similar to reservatol, lowers cholesterol.
SGTC_525 k781-2675 26.7 µM 0.134662328170018 0.430080330340583 no 1421 0.446439429792551 490 3651118 YDL195W SEC31
SGTC_3214 9129694 49.47 µM 0.134266903061284 0.430231903290245 no 1422 0.446595761879135 499 17158655
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.133985728211963 0.430339688491751 no 1423 0.44670692995407 490 364106
SGTC_1258 0671-0043 57.1 µM 0.133760641934152 0.430425976514241 no 1424 0.446795925314246 472 4298767
SGTC_2942 9052777 62.25 µM 0.13260440151733 0.430869279710161 no 1425 0.447253125629143 494 6469503
SGTC_3240 9133527 49.47 µM 0.130865634194047 0.431536087875254 no 1426 0.447940800387905 490 17617455
SGTC_2094 5332512 191.667 µM 0.130584405179327 0.431643956113706 no 1427 0.448052039971335 499 755774
SGTC_1085 doxorubicin 7.67 µM 0.130044686754093 0.431850984856533 no 1428 0.448265535968367 489 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1034 k072-0165 12.7 µM 0.129800767467691 0.431944555165168 no 1429 0.448362027850708 492 5835461
SGTC_1498 4478-3555 97.6 µM 0.128988014755472 0.432256364197001 no 1430 0.448683566220196 498 3437919
SGTC_2371 9071574 200 µM 0.125418057738388 0.433626459847409 no 1431 0.4500962964903 494 45596039
SGTC_1740 st038286 13.222 µM 0.124631014013301 0.433928623282606 no 1432 0.450407837094462 474 716786
SGTC_1980 st071811 45.7 µM 0.124449229915717 0.433998419700448 no 1433 0.450479798220015 494 4974850
SGTC_1370 2001-0092 44.6 µM 0.12419671373181 0.434095377277936 no 1434 0.450579762078435 502 790957
SGTC_2361 9034121 116 µM 0.123951319199357 0.434189604183787 no 1435 0.45067690968465 478 6496917
SGTC_636 0kpi-0074 126 µM 0.123449147078398 0.434382440525694 no 1436 0.450875720463828 484 616434
SGTC_1992 st073643 23.3 µM 0.122853675837371 0.434611124378516 no 1437 0.451111484488886 498 3161292
SGTC_43 0570-0105 72.5 µM 0.122207675958127 0.434859237912245 no 1438 0.451367273744006 510 1114046 YDL195W SEC31
SGTC_3034 9090421 49.47 µM 0.121876542843423 0.434986428394067 no 1439 0.451498396608141 496 17173761
SGTC_1306 1185-0270 9.02 µM 0.121562010299495 0.43510724871423 no 1440 0.451622950840295 501 1548076
SGTC_1647 st011722 22.4 µM 0.121370364847736 0.435180867803443 no 1441 0.45169884437564 473 2854783
SGTC_1142 3253-1408 9.78 µM 0.120461186237638 0.435530152169585 no 1442 0.452058912297721 490 256655
SGTC_1976 st070609 63.5 µM 0.119676472770423 0.4358316605007 no 1443 0.452369719198284 505 682556
SGTC_983 1491-0821 12.2 µM 0.118983832367108 0.43609782284506 no 1444 0.45264408234186 476 46495113
SGTC_895 0964-0006 13.7 µM 0.118748469970788 0.436188272628581 no 1445 0.452737317354373 500 6738897
SGTC_148 3253-0744 288.01 µM 0.118477020907691 0.436292594663998 no 1446 0.452844850752648 494 6893655
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.118052900979421 0.436455599321882 no 1447 0.453012870988533 498 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2083 5306046 65.942 µM 0.117781056737527 0.436560084592295 no 1448 0.45312056979682 474 539837
SGTC_883 0850-0245 24.6 µM 0.117225699051177 0.436773554024821 no 1449 0.453340601208887 497 6823229 YPR165W RHO1
SGTC_3029 9088683 49.47 µM 0.114355530443668 0.43787708696065 no 1450 0.454477982118172 478 25236615
SGTC_627 1391-0720 175 µM 0.113956548238678 0.438030527557555 no 1451 0.454636119233696 509 997839
SGTC_559 1550-0661 158 µM 0.112965829353233 0.438411578522825 no 1452 0.455028822992122 491 5830875
SGTC_3232 9132874 49.47 µM 0.112875829659828 0.43844619710011 no 1453 0.455064499490858 506 3784940
SGTC_3072 9116419 49.47 µM 0.112287167479792 0.438672638887442 no 1454 0.455297858160909 472 17170162
SGTC_2317 5986382 200 µM 0.112255003782693 0.43868501193636 no 1455 0.455310609004912 512 877883
SGTC_3279 9140807 49.47 µM 0.110844528572544 0.439227666247085 no 1456 0.455869817098782 500 45595718
SGTC_1929 genistein trimethyl ether 50.5 µM 0.110573873654575 0.439331808826697 no 1457 0.455977133108554 509 136420
SGTC_2261 9010538 184.68 µM 0.110468741079048 0.43937226286418 no 1458 0.456018819559741 492 6457250
SGTC_2008 4012253 172 µM 0.110258250524869 0.439453259574649 no 1459 0.456102283291994 496 603940
SGTC_2750 bromebric acid 70.15 µM 0.109030924221439 0.43992558478813 no 1460 0.456588981279736 483 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1607 st000305 50.6 µM 0.108848151056564 0.439995930687454 no 1461 0.456661465827276 504 5457690
SGTC_2752 diclazuril 33.15 µM 0.107049330317558 0.440688363143558 no 1462 0.457374922316166 475 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_327 1273-0057 3.96 µM 0.106264498339382 0.440990530883083 no 1463 0.457686249141924 519 3108138
SGTC_2193 5925765 200 µM 0.106095837985015 0.441055471206805 no 1464 0.457753156657869 482 877370
SGTC_1139 k015-0024 46.9 µM 0.105527027475179 0.44127449545906 no 1465 0.457978812446559 504 2766652
SGTC_3259 9138485 49.47 µM 0.105198854037727 0.441400868988687 no 1466 0.458109010011749 449 17646153
SGTC_2782 7736369 71.43 µM 0.103949191598357 0.441882145419964 no 1467 0.458604834636286 496 2950836 YOL077C BRX1
SGTC_1286 0929-0070 131 µM 0.103772503498495 0.441950199390715 no 1468 0.458674943831494 481 1420408
SGTC_2405 ticlatone 3.52 µM 0.100827718792798 0.443084676436321 no 1469 0.45984361127469 418 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1989 st071868 50.2 µM 0.100264155169298 0.443301842575927 no 1470 0.460067307041723 510 16414057
SGTC_1631 benzylvanillin 81.9 µM 0.0977959011346781 0.444253170470665 no 1471 0.461047181101818 478 75506
SGTC_3081 9117243 49.47 µM 0.0977394076373586 0.444274948283294 no 1472 0.46106961129025 495 45595589
SGTC_2373 9071805 200 µM 0.0976945153152948 0.444292254051258 no 1473 0.461087435434269 499 10149009
SGTC_2933 9026794 32.47 µM 0.0974300819404445 0.444394193962739 no 1474 0.461192428214858 511 17586027
SGTC_994 3910-0338 138 µM 0.0971522201592873 0.444501314531048 no 1475 0.461302755633692 504 3479481
SGTC_3304 9125678 46.087 µM 0.0967189853550474 0.444668342197547 no 1476 0.461474781191487 521 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2148 5546263 113.568 µM 0.0959451841366286 0.444966694947084 no 1477 0.46178205416703 486 792097
SGTC_622 1348-1566 26.3 µM 0.0958423198366299 0.445006358449229 no 1478 0.461822902838735 500 7340407
SGTC_1198 1612-1005 86.7 µM 0.0954434624202444 0.445160159303134 no 1479 0.461981297801717 511 6998509
SGTC_1672 st016598 6.51 µM 0.0951161852622897 0.445286364718817 no 1480 0.462111271190744 501 4665860 YNL267W PIK1
SGTC_292 k038-0015 474 µM 0.0932983252259672 0.445987472934238 no 1481 0.462833281278609 483 46368540
SGTC_1495 4469-0029 237 µM 0.0928812409720492 0.446148356964726 no 1482 0.462998954425864 486 793680
SGTC_1360 1598-0022 39.8 µM 0.0926444186382029 0.44623971159603 no 1483 0.463093027249981 504 761525
SGTC_1790 st045711 43.5 µM 0.0906233483800476 0.447019458604087 no 1484 0.463895939471327 501 585119
SGTC_759 3486-0358 89.3 µM 0.0894587291136738 0.447468872374804 no 1485 0.464358675712846 507 875103
SGTC_19 0279-0214 38.434 µM 0.0890248486185795 0.447636319364099 no 1486 0.464531081090362 514 3566274 YBR002C RER2
SGTC_218 alverine citrate 93.75 µM 0.0879442675892233 0.448053387231293 no 1487 0.4649604862175 504 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_668 1682-0499 62.6 µM 0.0876808037926151 0.448155084105155 no 1488 0.465065188603598 511 682214
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0874768980309331 0.44823379395126 no 1489 0.465146223863881 503 521171
SGTC_1948 st076329 66.6 µM 0.0842706359178154 0.449471712057722 no 1490 0.46642062923928 513 24208413
SGTC_1315 1237-0019 3.69 µM 0.0838857786123535 0.449620336404918 no 1491 0.466573623363769 513 825140
SGTC_3265 9137266 49.47 µM 0.0836494794408701 0.449711594016153 no 1492 0.466667562927327 508 17224265
SGTC_1613 st002381 52.1 µM 0.0816355158346739 0.45048948458691 no 1493 0.467468278993828 516 551167
SGTC_1153 4055-0057 267 µM 0.0806177710866429 0.450882659589364 no 1494 0.467872966461635 515 882706
SGTC_383 2324-0395 7.37 µM 0.0797954115662382 0.451200388625455 no 1495 0.468199986864275 525 3146421
SGTC_2989 9073649 71.4286 µM 0.0796543076661465 0.451254909056266 no 1496 0.468256100561411 522 21367202
SGTC_1646 st011709 75.6 µM 0.0795593465974021 0.451291601106792 no 1497 0.468293864696607 517 5757843
SGTC_1778 st046819 58.9 µM 0.0787697504906955 0.451596709592945 no 1498 0.468607882437979 532 671715
SGTC_1771 st048882 4.1505 µM 0.0783342040570531 0.451765021699626 no 1499 0.468781105071208 513 4580403
SGTC_2783 7738165 71.43 µM 0.0761616057602218 0.452604727207161 no 1500 0.469645264049004 520 17201110
SGTC_2556 citropten 84.59 µM 0.0752728135172562 0.452948305202903 no 1501 0.469998825885651 506 2775 A potential DNA crosslinker.
SGTC_1236 0330-0013 258 µM 0.0752302904651065 0.452964744108393 no 1502 0.470015742164454 505 4617066
SGTC_193 1273-0060 1.558 µM 0.0750795585145437 0.453023015934303 no 1503 0.470075705927589 520 2847393 YHR072W ERG7
SGTC_3060 1327-0027 12.5 µM 0.0749264129314555 0.453082221888247 no 1504 0.470136630570254 521 16000455 YPR107C YTH1
SGTC_1833 st055984 71 µM 0.0746572198140116 0.453186294248742 no 1505 0.470243723138755 489 676288
SGTC_121 0557-0495 61.343 µM 0.0739826460629239 0.45344710433677 no 1506 0.470512096924913 515 3104427
SGTC_1919 st067113 52.3 µM 0.0736499343225446 0.453575747900014 no 1507 0.470644468576732 518 1268243
SGTC_637 1181-0519 7.26 µM 0.0731245713369105 0.453778890310471 no 1508 0.470853494449157 517 6252091 YGR060W ERG25
SGTC_1358 1509-0022 2.48 µM 0.071625537171796 0.454358589024594 no 1509 0.471449958271133 489 3258434
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0716072198964513 0.454365673190098 no 1510 0.471457247090908 504 165521
SGTC_685 1278-0033 54.9 µM 0.0711349813717966 0.454548315394236 no 1511 0.471645163784857 528 3590572
SGTC_95 0471-0001 561.058 µM 0.069306612454898 0.455255542670887 no 1512 0.472372781209294 522 4015405
SGTC_76 0433-0009 400.328 µM 0.0689680164271422 0.455386529871894 no 1513 0.472507539025881 520 2841569
SGTC_2469 5655019 90.81 µM 0.0677997588991927 0.455838512025555 no 1514 0.472972517846498 522 2788239
SGTC_1132 3456-3614 2.5 µM 0.0675311955543785 0.455942423449615 no 1515 0.473079414120519 491 3125502
SGTC_1084 voriconazole 435 nM 0.0673611665248881 0.45600821194029 no 1516 0.473147091781594 529 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1016 4226-1401 38 µM 0.0670662940954666 0.456122308328289 no 1517 0.473264463436813 523 2901613
SGTC_3087 9117406 49.47 µM 0.0665431133868687 0.456324754020881 no 1518 0.473472717116142 511 42546093
SGTC_2238 6671620 73.2395 µM 0.0661202009970185 0.456488409001023 no 1519 0.473641063986679 493 729941
SGTC_2760 etidronate 98.04 µM 0.065478560021508 0.456736719763531 no 1520 0.473896488160402 524 3305 A chelator and antioxidant.
SGTC_2531 methyl deoxycholate 70.07 µM 0.0649860230146875 0.456927339754839 no 1521 0.474092564374159 520 16667744 Haematoxylin.
SGTC_3255 9139072 49.47 µM 0.0642947688400437 0.457194883292379 no 1522 0.474367759349769 517 17646060
SGTC_1684 st024538 14.6195 µM 0.063589377056811 0.457467918660815 no 1523 0.474648595252064 526 6732859
SGTC_2378 9074213 121.43 µM 0.0635686913468959 0.45747592576372 no 1524 0.474656830993873 523 657714
SGTC_1335 1486-0900 202 µM 0.0634728086573898 0.457513040623546 no 1525 0.474695005559917 515 X1335
SGTC_287 k060-0039 29.6 µM 0.0633429280959589 0.457563316179106 no 1526 0.474746716349572 511 5861974
SGTC_2149 5554786 194.827 µM 0.0625999775289148 0.45785091845197 no 1527 0.475042523656694 506 745063 YPR165W RHO1
SGTC_725 1497-0963 19 µM 0.061390507633197 0.458319161337149 no 1528 0.475524105956734 527 3549977
SGTC_2132 5317594 122.667 µM 0.0612659501984326 0.458367386695848 no 1529 0.475573703823461 516 794577
SGTC_1416 3966-0321 25.3 µM 0.0609044640370577 0.458507348085801 no 1530 0.475717647130344 511 582530 YLR208W SEC13
SGTC_964 1287-0107 19.4 µM 0.0602284944427912 0.458769085986866 no 1531 0.475986825809737 522 51516812 YPR165W RHO1
SGTC_387 norethindrone acetate 66.7 µM 0.0592706769491148 0.459139987009334 no 1532 0.476368258222952 520 541197
SGTC_630 4356-0227 183 µM 0.0583064514972229 0.459513405348275 no 1533 0.476752264354131 530 779312
SGTC_1331 1472-0049 76.2 µM 0.0578196034694168 0.459701961963092 no 1534 0.476946161494828 526 24051409
SGTC_1781 st038725 66.3 µM 0.0560639933026951 0.460381986102054 no 1535 0.477645413992082 511 4270275 YIL048W NEO1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.055054511625474 0.460773054845985 no 1536 0.478047517805027 518 17037758
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.054930358593921 0.46082115380988 no 1537 0.478096972861758 522 2333 A French combination drug.
SGTC_3242 9133940 49.47 µM 0.0521133428645151 0.461912665581788 no 1538 0.479219190672479 515 17248444
SGTC_1953 st076800 12.1 µM 0.0519611825933398 0.461971631508416 no 1539 0.47927981170526 510 297591
SGTC_169 k015-0017 16.025 µM 0.0509215503297071 0.462374537419898 no 1540 0.479694016552577 528 1840002
SGTC_2135 5326629 150.42 µM 0.0508712851491336 0.462394018499707 no 1541 0.479714043502172 516 5020077
SGTC_1697 st025554 27.742 µM 0.050736776537998 0.462446149920583 no 1542 0.479767635467786 521 1269519
SGTC_2875 9039966 71.43 µM 0.0496302824267044 0.462875017570684 no 1543 0.480208507236887 513 6463691
SGTC_1029 k015-0030 64.7 µM 0.0494266483972303 0.462953949094897 no 1544 0.480289645880434 527 2208316
SGTC_1782 st039423 80.636 µM 0.0476619960355717 0.463638014882357 no 1545 0.480992811215712 514 2068169
SGTC_2628 lathosterol 100 µM 0.0475635050535768 0.463676198003361 no 1546 0.481032058920667 504 6710616
SGTC_1126 isoteolin 1.0172 µM 0.0475441497405486 0.463683701737408 no 1547 0.481039771847575 515 133323
SGTC_2499 avocadenofuran 51.48 µM 0.0474377353439055 0.463724957065878 no 1548 0.481082177202347 498 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3047 9092122 49.47 µM 0.0468715077850742 0.463944481882011 no 1549 0.481307818310295 517 17173831
SGTC_1418 3966-3099 2.4 µM 0.046800925550904 0.463971847184556 no 1550 0.481335945680282 533 740335
SGTC_3128 9127691 49.47 µM 0.04663559951597 0.464035946091232 no 1551 0.481401829287697 529 41316314
SGTC_57 miconazole 162.5 nM 0.0460541925556929 0.464261372016401 no 1552 0.481633528142231 530 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1974 st069448 26.9 µM 0.0446217227715892 0.464816824951397 no 1553 0.482204413817699 523 6323587 YNR016C ACC1
SGTC_1336 1486-0901 104 µM 0.0444789380110652 0.464872194791462 no 1554 0.482261320195638 525 5006114
SGTC_2900 5328528 85.29 µM 0.0441209377150155 0.465011025054258 no 1555 0.482404001575658 531 795359
SGTC_1399 3562-5772 25 µM 0.0435857185934074 0.465218587601247 no 1556 0.482617317895514 526 23847490
SGTC_1868 st057644 42.7 µM 0.0435653347641519 0.465226492811771 no 1557 0.482625442149902 518 688665
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0423945142762698 0.465680580697486 no 1558 0.483092100696454 534 279621
SGTC_1951 sophoraflavanone G 9.2 µM 0.041675176638887 0.465959588881902 no 1559 0.483378821468274 513 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_657 3534-0529 86.7 µM 0.0404939560761788 0.466417782991705 no 1560 0.483849662721865 527 1049549
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0404406300559028 0.466438469148848 no 1561 0.483870919313952 525 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_736 0958-0254 92.6 µM 0.0394079411793495 0.466839086222554 no 1562 0.484282574341788 528 6812352
SGTC_684 1140-0066 328 µM 0.0383482498957795 0.467250213421971 no 1563 0.48470501060102 528 6813534
SGTC_3103 9120822 49.47 µM 0.0374986984378272 0.467579838172107 no 1564 0.485043688957316 536 17141819
SGTC_2205 7238770 200 µM 0.0371194809172037 0.467726981217701 no 1565 0.485194869602909 528 279867
SGTC_3201 9113999 49.47 µM 0.0361977673438337 0.468084640586386 no 1566 0.48556233311299 516 16649224
SGTC_1362 1611-0397 101 µM 0.0353359355524271 0.468419086895045 no 1567 0.485905934393242 527 27816
SGTC_1215 3852-0577 11.2 µM 0.034364521387289 0.468796084940088 no 1568 0.486293237291723 529 2884876
SGTC_2551 apiole 73.87 µM 0.0341509116515297 0.468878988929796 no 1569 0.486378405255811 527 10659 A possible DNA adduct former.
SGTC_438 sphingosine 6.67 µM 0.0322624634528135 0.469611972102629 no 1570 0.487131371718267 534 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1363 1636-0063 10.4 µM 0.0321581656836464 0.469652457311806 no 1571 0.487172958929067 529 6072185
SGTC_599 1935-0052 86.5 µM 0.0284912088498437 0.471076054392766 no 1572 0.488635189753038 533 9557311
SGTC_2304 7443016 91.4 µM 0.0282162528433542 0.471182813770896 no 1573 0.488744837245396 544 939854
SGTC_85 0868-0259 160.055 µM 0.0277540700816492 0.47136227384817 no 1574 0.488929149300772 536 83173
SGTC_1825 st052143 62.6 µM 0.0273691711188158 0.471511729983641 no 1575 0.489082643458333 535 674173
SGTC_2020 4017018 200 µM 0.0273366391104113 0.471524362335538 no 1576 0.489095616997763 533 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1982 st072467 71.9 µM 0.0268040398650732 0.471731177519902 no 1577 0.489308015515304 511 3163533
SGTC_2733 amorolfine 100 µM 0.0267654446133583 0.471746164852854 no 1578 0.489323407270849 541 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_955 1216-0110 33 µM 0.0265532581422267 0.47182856195376 no 1579 0.489408027349377 528 3619719
SGTC_3091 9116372 49.47 µM 0.0255239384365018 0.472228288555259 no 1580 0.489818527297087 528 17169793
SGTC_2970 9090938 41.86 µM 0.025159861131236 0.472369681261332 no 1581 0.489963726494878 510 17217104
SGTC_2853 9015042 58.44 µM 0.0235847094158823 0.472981445533021 no 1582 0.490591934439182 536 6457456
SGTC_2680 butyl paraben 22.24 µM 0.0231221404596084 0.473161112246643 no 1583 0.490776422436678 538 7184 An antifungal and steroid mimetic.
SGTC_679 0422-0091 41.4 µM 0.0229981559196382 0.473209270093051 no 1584 0.49082587196211 535 627384 YHR062C RPP1
SGTC_718 1130-0073 349 µM 0.0224377836462153 0.473426933732305 no 1585 0.4910493704699 535 6740020
SGTC_1243 0416-0003 5.65 µM 0.0224336136987795 0.473428553481689 no 1586 0.491051033619605 534 2141977
SGTC_2462 5162487 171.77 µM 0.0194941337285512 0.474570455206538 no 1587 0.492223458380845 541 2259986
SGTC_35 0133-0054 64.071 µM 0.0176395765897457 0.475291004334051 no 1588 0.492963192014465 537 99677
SGTC_1920 st075728 45.7 µM 0.0158330429065277 0.475992972687178 no 1589 0.493683793654904 538 3400306
SGTC_6 0844-0013 19.835 µM 0.0140187097017848 0.476698046711813 no 1590 0.494407527159946 545 1584900
SGTC_1505 k297-0037 20.6 µM 0.0136940557507459 0.476824219316137 no 1591 0.49453703291384 542 4089396
SGTC_2552 juarezic acid 87.02 µM 0.012414542529917 0.477321508261521 no 1592 0.49504744130874 540 1549512
SGTC_324 1315-0088 19.6 µM 0.0123948242279059 0.477329172152405 no 1593 0.495055307167903 545 6787421
SGTC_199 4063-0024 41.6 µM 0.0122545849680264 0.477383679033919 no 1594 0.495111250289 542 306215
SGTC_184 1494-0393 24.714 µM 0.0117313491994323 0.477587049135811 no 1595 0.495319976146138 539 3090647
SGTC_2910 7948405 25.97 µM 0.0113816026392047 0.477722991100319 no 1596 0.495459495518861 541 2971328
SGTC_3203 9113543 49.47 µM 0.0108090287895476 0.477945548738465 no 1597 0.495687905373274 540 17018012
SGTC_2997 9067075 71.4286 µM 0.0101604484606856 0.478197658158245 no 1598 0.495946637262603 541 27209819
SGTC_1395 3486-0190 4.35 µM 0.00979446923779657 0.478339921663594 no 1599 0.496092634580372 542 6748079
SGTC_158 k038-0087 26.446 µM 0.00961406598758975 0.478410049062135 no 1600 0.496164601675553 536 X158
SGTC_1703 st026983 48.3 µM 0.00949234227186944 0.478457366589232 no 1601 0.496213160196385 541 1104023
SGTC_2722 naftopidil 47.16 µM 0.00828028174978733 0.478928546009379 no 1602 0.496696683264004 539 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_546 peri-Naphthalide 147 µM 0.00813783488357178 0.478983923104845 no 1603 0.496753509426849 542 223824 A penicillin ester.
SGTC_420 mitomycin C 81.9 mM 0.00676890665240706 0.479516122902319 no 1604 0.497299617565344 542 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_72 0744-0168 198.391 µM 0.00663337489395365 0.479568815741726 no 1605 0.497353685700101 545 677577
SGTC_520 3584-0023 682 µM 0.00615513744086415 0.479754750576573 no 1606 0.49754447093808 542 1340790
SGTC_2159 5658611 73.75 µM 0.00615303713628742 0.479755567167667 no 1607 0.497545308822511 540 793844
SGTC_2857 9024691 58.44 µM 0.00558097395656594 0.479977986488572 no 1608 0.497773525081015 544 16478292
SGTC_1638 st008370 60.6 µM 0.00466684014228825 0.480333416475459 no 1609 0.498138206909491 546 24207134
SGTC_2078 5212016 200 µM 0.00459923323539383 0.480359703756902 no 1610 0.498165177873625 544 1899708
SGTC_2686 alizarin 95.37 µM 0.00442575083930579 0.480427158506463 no 1611 0.498234386631605 543 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_134 0269-0018 6.916 µM 0.00401714114241181 0.480586039459296 no 1612 0.498397396862267 545 4378915
SGTC_2776 terbinafine 19.92 µM 0.00289754472157808 0.481021391272954 no 1613 0.498844048518725 547 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2868 9035608 32.47 µM 0.0026517125292598 0.481116985455186 no 1614 0.498942120996368 547 6462614
SGTC_2027 5150920 200 µM 0.00148076421390521 0.481572334635539 no 1615 0.49940926076365 547 786715
SGTC_2400 5203494 178.7 µM 1.11287039016304e-05 0.482143868897814 no 1616 0.499995560289488 547 6777674
SGTC_1089 terbinafine 2.25 µM -9.27414198534724e-05 0.482184264897406 no 1617 0.499963001526529 549 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2090 5301565 104.445 µM -9.8744483981931e-05 0.482186599547144 no 1618 0.499960606650447 548 2056344
SGTC_731 3966-0296 387 µM -0.000771023061117184 0.482448059038343 no 1619 0.499692406332232 549 660956
SGTC_1914 st062367 72.6 µM -0.00246884294134984 0.483108400686574 no 1620 0.499015075167575 550 978205
SGTC_3198 9112019 49.47 µM -0.00302279975868085 0.483323864019058 no 1621 0.498794079207556 550 45595555
SGTC_2080 5212524 12.4 µM -0.00329199652155647 0.48342857075073 no 1622 0.498686685772734 551 260183
SGTC_2170 morpholine 200 µM -0.00329573173456053 0.483430023606664 no 1623 0.498685195646424 550 121171 Reacts with secondary amines.
SGTC_3268 9137683 49.47 µM -0.00477998775393219 0.484007360014077 no 1624 0.498093068046845 550 1953228
SGTC_2991 9074669 71.4286 µM -0.0060712899678356 0.484509669803654 no 1625 0.49757792061513 553 17333109
SGTC_91 0417-1751 58.384 µM -0.00613132276683815 0.484533022851819 no 1626 0.49755397143917 551 6795624
SGTC_2483 5729050 27.16 µM -0.00636880258087919 0.484625404163374 no 1627 0.497459232551254 555 2865180
SGTC_1621 st003705 32.4 µM -0.00737067689169858 0.48501514931608 no 1628 0.497059551976974 550 24207032
SGTC_519 k048-0011 62.8 µM -0.00758103204531789 0.485096982670727 no 1629 0.496975634757482 551 6836379
SGTC_2427 5545055 42.75 µM -0.00805374865768418 0.48528088340316 no 1630 0.496787053878244 549 5372858
SGTC_430 0958-0115 16.4 µM -0.0108024810636542 0.48635028232701 no 1631 0.495690517385474 559 6833180
SGTC_66 0109-0187 42.4 µM -0.0119464378238318 0.48679536998049 no 1632 0.495234174213182 555 759417
SGTC_2150 5556613 200 µM -0.0120305105910247 0.486828081444729 no 1633 0.495200636441898 553 743190
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0128210958444051 0.487135690722162 no 1634 0.494885262914144 560 77254
SGTC_247 mechlorethamine 29.705 µM -0.0162910147370126 0.488485891561635 no 1635 0.493501112896399 554 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2195 6536160 144.242 µM -0.0165174953244719 0.488574023529695 no 1636 0.493410772370681 558 3834386
SGTC_164 4100-3994 89.624 µM -0.0172230485135616 0.488848583912166 no 1637 0.493129337430214 557 4615967
SGTC_2266 7929956 200 µM -0.0178529672430098 0.489093716218603 no 1638 0.492878074864832 555 2967153
SGTC_1202 1988-0068 29.6 µM -0.0179935149789929 0.489148410808954 no 1639 0.492822013435962 556 2850480
SGTC_1187 1391-0724 117 µM -0.0181074933158593 0.489192765984566 no 1640 0.492776550065417 562 6997986
SGTC_1284 0929-0043 16 µM -0.0190041770044798 0.489541719039526 no 1641 0.492418886622324 556 1239883
SGTC_3082 9117008 49.47 µM -0.0196025592489007 0.489774589697415 no 1642 0.492180211120521 551 41448529
SGTC_1609 st001574 46.4 µM -0.0232217205848719 0.491183119518686 no 1643 0.490736706378408 564 3960012
SGTC_2513 baicalein 25.65 µM -0.0235449047463719 0.49130890413541 no 1644 0.4906078097964 563 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2226 7298446 200 µM -0.0248750803007434 0.491826622943117 no 1645 0.490077302060876 559 3283010
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0251242776602513 0.491923614826157 no 1646 0.489977917759911 566 803109
SGTC_639 0833-0042 114 µM -0.025264049036865 0.491978016450719 no 1647 0.489922174742368 559 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3311 9131146 2.8755 µM -0.0258140539719351 0.49219209006056 no 1648 0.489702826068104 566 4900406 YPR165W RHO1
SGTC_2442 5158906 48.48 µM -0.0259872130244684 0.492259487712277 no 1649 0.489633768768082 553 1893835
SGTC_2974 9094440 9.66 µM -0.0262985977315318 0.49238068665498 no 1650 0.489509586686932 561 25236134
SGTC_2797 7859098 81.82 µM -0.0263146309906192 0.492386927231233 no 1651 0.489503192554863 555 972681
SGTC_450 aminopyrene 156 nM -0.0270633377763911 0.492678346126065 no 1652 0.489204608129431 557 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_888 0916-0002 6.97 µM -0.0276752055455873 0.492916506124437 no 1653 0.488960599617791 567 2802138 YIL048W NEO1
SGTC_44 0929-0055 61.211 µM -0.0277389475953983 0.492941316871127 no 1654 0.48893517997806 554 1379590
SGTC_1196 1588-0294 184 µM -0.0281339692223297 0.493095074400621 no 1655 0.488777650633974 562 6144269
SGTC_2704 st078022 71.1 µM -0.02832749501525 0.493170402418747 no 1656 0.488700475772267 566 54697681
SGTC_478 N-arachidonylglycine 10 µM -0.0288754151726577 0.493383676281779 no 1657 0.48848197664707 559 5283389
SGTC_3126 9127922 49.47 µM -0.0293324585572944 0.493561578483445 no 1658 0.488299719924183 556 45595682
SGTC_2812 7970281 58.44 µM -0.0294787823854845 0.493618534686124 no 1659 0.488241370395136 569 2233435
SGTC_392 N-ethylmaleimide 8.33 µM -0.0307905339492172 0.494129136540608 no 1660 0.487718294828232 560 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_212 3807-4682 38.772 µM -0.0317243787247872 0.494492643350975 no 1661 0.487345926629074 559 3125501 YBL034C STU1
SGTC_3282 9108498 15.4605 µM -0.0323538728370425 0.494737681744695 no 1662 0.487094923677605 573 16459645
SGTC_3162 9099653 49.47 µM -0.033786140623116 0.495295217003274 no 1663 0.486523843908718 555 25237511
SGTC_1073 triclabendazole 3.09 µM -0.0353575527856943 0.495906927173283 no 1664 0.485897315750621 564 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_67 0335-0847 266 µM -0.0364235887391699 0.496321913004253 no 1665 0.485472302781265 587 4552207 YOR254C SEC63
SGTC_3149 9097855 49.47 µM -0.0382464934113655 0.497031541207895 no 1666 0.484745575805767 562 25236625 YMR079W SEC14
SGTC_2285 7945142 200 µM -0.0385921966517414 0.497166119186315 no 1667 0.484607761914762 564 2970608
SGTC_299 1273-0059 1.44 µM -0.0388962471584631 0.497284482539841 no 1668 0.484486554320122 568 2848077
SGTC_572 0960-0087 17.7 µM -0.0392258293235287 0.497412785342995 no 1669 0.484355170328975 566 6796365
SGTC_1012 4112-3522 18 µM -0.0399944828150715 0.497712014922862 no 1670 0.484048762425622 588 3112398
SGTC_2160 5660466 132.927 µM -0.0416267176470091 0.49834743266178 no 1671 0.483398137047382 576 2859134
SGTC_1127 asiatic acid 681.4 nM -0.0420128932799726 0.498497768839942 no 1672 0.483244209920834 577 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_576 1073-0113 22.7 µM -0.0420273512324343 0.498503397250393 no 1673 0.483238447122215 573 5439563
SGTC_2237 6667747 47.222 µM -0.0420884243256429 0.49852717271129 no 1674 0.483214104022507 585 729940 YDL015C TSC13
SGTC_2352 9027995 87.8 µM -0.0421232019821724 0.498540711487739 no 1675 0.483200242038305 576 2997347
SGTC_1523 st012844 44.7 µM -0.0424635585888701 0.498673210783902 no 1676 0.483064580783086 581 4274103
SGTC_3251 9135047 49.47 µM -0.0433649619416442 0.499024123723173 no 1677 0.482705303866728 568 17682963
SGTC_1052 3253-3998 198 µM -0.0456444679106624 0.499911529585965 no 1678 0.481796812909646 580 5450317
SGTC_1059 3448-6867 171 µM -0.0460989806110534 0.499911529585965 no 1679 0.481615679250414 568 3934407
SGTC_1209 2323-2347 50.3 µM -0.0463321187867545 0.499820769394324 no 1680 0.481522769849689 558 5412760
SGTC_927 2425-1185 123 µM -0.0475684234387713 0.499339478913206 no 1681 0.481030098987311 588 730375
SGTC_1596 piperlongumine 63 µM -0.0486136869550983 0.498932561016857 no 1682 0.480613581124777 585 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_345 1362-0200 395 µM -0.0496268976178735 0.498538122254416 no 1683 0.480209855918318 582 1419823
SGTC_104 0074-0074 590.992 µM -0.050310701089152 0.498271921146936 no 1684 0.479937398167135 591 3943124
SGTC_2214 7179297 48.276 µM -0.0514731243335484 0.497819397699468 no 1685 0.479474258564502 568 769744
SGTC_375 3970-0961 9.27 µM -0.0521965328598796 0.49753778106934 no 1686 0.479186047773321 572 2898222
SGTC_1977 st070720 65.3 µM -0.052793143301343 0.497305526744841 no 1687 0.478948362368326 591 682188
SGTC_3109 9122853 49.47 µM -0.0547635305734599 0.496538482111117 no 1688 0.478163427583265 612 1234709
SGTC_1941 st076221 61.8 µM -0.0553952829533034 0.496292552181869 no 1689 0.477911776863596 579 2828568
SGTC_3328 9140624 29.0385 µM -0.0558485070982253 0.496116120971591 no 1690 0.47773124606999 568 4904392
SGTC_574 1315-0397 40 µM -0.0563118227605886 0.49593576211833 no 1691 0.47754670028988 566 6794277
SGTC_321 4534-3890 65.3 µM -0.0566921726068442 0.495787700697653 no 1692 0.477395204671926 580 699746
SGTC_3264 9137442 49.47 µM -0.0570605166345685 0.495644313418021 no 1693 0.47724849415666 581 17015726
SGTC_1408 3909-7976 48.8 µM -0.0571818870141843 0.495597067033705 no 1694 0.477200153309063 576 24152374
SGTC_2414 st077232 92.9 µM -0.0572524515684713 0.495569598086003 no 1695 0.477172048167908 566 729801
SGTC_1564 D-Arginine 115 µM -0.0573337077336702 0.495537967197972 no 1696 0.477139684808004 599 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3211 9128781 49.47 µM -0.0578659046756693 0.495330797628172 no 1697 0.476927720861031 594 17194361
SGTC_2983 9022671 12.99 µM -0.0579821563889186 0.495285544212812 no 1698 0.476881420875362 565 6405161
SGTC_3286 9117135 37.221 µM -0.0580538010085101 0.495257655073548 no 1699 0.476852886871838 564 3438150
SGTC_2945 9067681 61.76 µM -0.0584808767852035 0.495091407543842 no 1700 0.476682797268221 568 16456930
SGTC_481 bay k-8644 50 µM -0.0584985379171282 0.495084532623839 no 1701 0.476675763537629 608 2303 A calcium channel antagonist.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0585602666267758 0.495060503601253 no 1702 0.476651179490198 573 71034 A hepatoprotective.
SGTC_2869 9037858 32.47 µM -0.0591501869304723 0.494830867313636 no 1703 0.476416242598343 564 27187042
SGTC_2019 4016004 108 µM -0.0602733317825416 0.494393669302255 no 1704 0.475968970737098 582 45595336
SGTC_2376 9072922 81.32 µM -0.0607126184111615 0.494222673357142 no 1705 0.475794041090901 615 17087968
SGTC_790 1575-0012 79.1 µM -0.0607677565595439 0.494201210452229 no 1706 0.475772084692275 609 378741 YLR208W SEC13
SGTC_2122 5258151 111.688 µM -0.060857052105085 0.494166451580294 no 1707 0.47573652673385 587 2173356
SGTC_534 k292-0788 63.4 µM -0.061372728128418 0.493965722208573 no 1708 0.475531185603342 601 4146317
SGTC_2351 9026858 72.31 µM -0.0621347959011191 0.493669086475776 no 1709 0.475227743699544 586 1409300
SGTC_2438 5259590 200 µM -0.0625392967675326 0.493511635472965 no 1710 0.475066684437455 576 1201127
SGTC_3307 9126885 69.2785 µM -0.0638379680960055 0.493006137693163 no 1711 0.474549622866102 584 24824909
SGTC_1448 4255-0083 152 µM -0.0641607977257931 0.492880480465638 no 1712 0.474421095965701 609 5399660
SGTC_3013 9080133 71.4286 µM -0.0644310186693288 0.492775301026484 no 1713 0.47431351600241 574 17050193
SGTC_1722 st034304 3.6505 µM -0.0646962852421831 0.49267205049014 no 1714 0.474207910287638 575 4036148 YLR033W RSC58
SGTC_2116 5511452 16.8835 µM -0.0650539765288637 0.49253282597249 no 1715 0.474065512087864 602 870744
SGTC_658 3253-0951 102 µM -0.0652721348233949 0.492447912458778 no 1716 0.473978664104392 583 1184878
SGTC_2982 9019404 25.97 µM -0.0656101630267892 0.49231634278923 no 1717 0.473844098812334 583 22333232
SGTC_2432 5630864 12.22 µM -0.0670332579783613 0.491762445288989 no 1718 0.473277613348611 597 5714970
SGTC_568 1193-0097 7.48 µM -0.0670643007839892 0.49175036297078 no 1719 0.473265256866705 585 3646150
SGTC_277 nystatin 15.5 µM -0.0673618071086966 0.491634569502851 no 1720 0.473146836804773 601 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_102 gallobenzophenone 83.616 µM -0.0684940735811962 0.491193882674531 no 1721 0.472696168797846 578 70837
SGTC_581 0958-0271 211 µM -0.0687687160250381 0.49108699132028 no 1722 0.47258686005549 586 4591145
SGTC_1835 st008666 49.2 µM -0.0692058310788469 0.490916866644685 no 1723 0.472412890854388 586 690455
SGTC_1773 st048542 73.5835 µM -0.0698786762272816 0.490654999327793 no 1724 0.472145112769189 585 3237138
SGTC_182 3448-4371 550.524 µM -0.0700523184479519 0.490587419460972 no 1725 0.472076008890591 574 3491403
SGTC_590 k048-0076 22.4 µM -0.0704342545278827 0.490438774599442 no 1726 0.471924013884494 590 6832814
SGTC_2836 9010338 19.48 µM -0.0706751960746389 0.490345003771416 no 1727 0.471828131062734 581 2994051
SGTC_1391 3442-0225 151 µM -0.0707908435063812 0.490299995718674 no 1728 0.471782109682902 583 5227075
SGTC_1156 4092-0367 4.88 µM -0.0708161272084339 0.490290155739715 no 1729 0.47177204819657 578 1357585
SGTC_1807 st050092 58.9 µM -0.0713978329908806 0.490063767567695 no 1730 0.471540567116431 599 5008496
SGTC_2319 6033012 152.6 µM -0.0719479395260367 0.489849680129813 no 1731 0.471321669325523 581 847246
SGTC_2612 dictamnine 15.46 µM -0.0720749477685906 0.489800252173309 no 1732 0.471271131573163 580 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2905 7799065 20.05 µM -0.0721084290563631 0.489787222244756 no 1733 0.47125780913665 595 1296806
SGTC_965 1291-5240 308 µM -0.0724088569315096 0.489670305076223 no 1734 0.471138268243333 582 2834598
SGTC_2994 9053520 71.4286 µM -0.0734637188739286 0.489259792770914 no 1735 0.470718557089081 600 4647384
SGTC_971 1315-0384 26.7 µM -0.0744894879859492 0.488860613200246 no 1736 0.47031045265087 601 6769120
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0751794475411656 0.488592120668666 no 1737 0.470035968278373 614 5024745
SGTC_3234 9132280 49.47 µM -0.0757750729959644 0.488360341690735 no 1738 0.469799023980921 581 17612295
SGTC_712 r015-0009 80.6 µM -0.0758898856500688 0.488315664466679 no 1739 0.469753351868096 594 6813872 YLR060W FRS1
SGTC_1056 3448-1962 115 µM -0.0759456655883007 0.488293958786712 no 1740 0.469731162927638 590 715507
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0769020588901263 0.487921802349717 no 1741 0.469350729821162 585 6857784
SGTC_1932 st074806 40.9 µM -0.0769323809447503 0.487910003453883 no 1742 0.469338668802421 578 17251235
SGTC_1276 0871-0068 94.2 µM -0.0771837813797174 0.487812179108068 no 1743 0.469238671869315 587 3414906
SGTC_2097 5376186 200 µM -0.0773034705133569 0.487765606211258 no 1744 0.469191065050385 584 742755
SGTC_2489 cantharidin 73.42 µM -0.0787750385164033 0.487193010126411 no 1745 0.468605779355983 585 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2329 6138490 200 µM -0.0796158495937611 0.486865857183968 no 1746 0.468271394540277 627 720019
SGTC_2182 6325192 200 µM -0.0800099743208448 0.486712509397885 no 1747 0.468114661522311 568 736248
SGTC_549 1661-1316 519 µM -0.0803343422895041 0.48658630435171 no 1748 0.467985672635479 595 2857282
SGTC_53 0973-0023 39.979 µM -0.0817529403849488 0.486034372345058 no 1749 0.467421589438044 605 674768
SGTC_1470 k295-0292 231 µM -0.0821766959244755 0.485869507502204 no 1750 0.467253102357269 576 5045612
SGTC_100 0086-0128 49.5915 µM -0.0834142847811715 0.485388029455583 no 1751 0.46676106524157 618 93297
SGTC_3281 9140613 49.47 µM -0.0835743237315497 0.4853257686052 no 1752 0.466697441096244 589 16013766
SGTC_1640 st009078 66.4 µM -0.0844122681608356 0.484999784259523 no 1753 0.466364326759163 590 690618
SGTC_2295 7971645 200 µM -0.0860882520621634 0.484347808888141 no 1754 0.465698131224683 598 2978226 YKL099C UTP11
SGTC_880 0833-0487 87.2 µM -0.0873715767635722 0.483848610272326 no 1755 0.465188080708537 572 76075
SGTC_2703 st077852 53.4 µM -0.0879114746771885 0.483638603685722 no 1756 0.464973518221875 604 6281836
SGTC_3180 9109287 49.47 µM -0.0889803418849183 0.483222854911938 no 1757 0.464548766522041 587 18891271
SGTC_878 0828-0289 13.7 µM -0.0894401335721095 0.48304401898223 no 1758 0.464366064641245 580 745350 YLR208W SEC13
SGTC_2849 9019321 12.99 µM -0.0918767533266137 0.482096353778234 no 1759 0.463397980742229 584 16489627
SGTC_1861 st057647 17.4 µM -0.0919656599444201 0.48206177754757 no 1760 0.463362661663455 575 688668
SGTC_2429 5902844 64.44 µM -0.0919789283733284 0.482056617400422 no 1761 0.463357390666805 585 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2618 avocadyne 43.43 µM -0.0936021423277518 0.481425365689018 no 1762 0.462712603878381 592 3015189
SGTC_3212 9128307 49.47 µM -0.0936708218796266 0.481398657912295 no 1763 0.462685324553568 629 27243542
SGTC_2576 guaiol 23.12 µM -0.0948808069388453 0.480928138491879 no 1764 0.462204750789189 590 227829
SGTC_301 4119-0100 24.5 µM -0.0953272122905177 0.480754554272946 no 1765 0.462027464394904 611 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2068 5226020 147 µM -0.0959048439384968 0.48052994827697 no 1766 0.4617980737051 612 1810509
SGTC_1494 4358-1428 177 µM -0.0965360643577955 0.480284511920844 no 1767 0.461547416226165 616 1564571
SGTC_188 3229-0966 278.469 µM -0.0967456606645563 0.480203016595685 no 1768 0.461464188955319 592 5722370
SGTC_3147 9097027 49.47 µM -0.0972462287836365 0.480008388840991 no 1769 0.461265428364082 593 25236841
SGTC_1032 k061-1018 98.7 µM -0.0986204804534915 0.479474085572768 no 1770 0.46071980412079 622 4005393
SGTC_2985 9022375 71.43 µM -0.0991659108284067 0.47926203470758 no 1771 0.460503270314537 631 4939335
SGTC_560 2332-1943 155 µM -0.0994625780153221 0.479146699745594 no 1772 0.460385499471131 589 21177716
SGTC_3290 9121031 71.43 µM -0.100144719147245 0.478881511159126 no 1773 0.460114716504683 589 17014854
SGTC_2292 7671323 168.05 µM -0.101045900589981 0.478531183006813 no 1774 0.45975701160578 607 937504
SGTC_1608 st001473 40.5 µM -0.101093061380213 0.478512850024962 no 1775 0.459738293022689 631 7292267
SGTC_3095 9117207 49.47 µM -0.101161440729302 0.478486268757957 no 1776 0.459711152742687 585 17015229
SGTC_2455 5377712 9.75 µM -0.101362907754264 0.478407952558947 no 1777 0.459631190051053 588 2243908
SGTC_2071 5230951 39.92 µM -0.101878565928491 0.478207504760524 no 1778 0.459426531668678 584 1799272
SGTC_1129 3453-1384 223 µM -0.102140971825098 0.478105503866813 no 1779 0.459322390122355 649 1084452
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.102202939581273 0.478081416330179 no 1780 0.459297797263743 590 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1092 toremifene 6.32 µM -0.102268480070435 0.47805594012074 no 1781 0.459271786680494 631 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2966 9084041 48.03 µM -0.103034966693205 0.477758006188256 no 1782 0.458967609610105 606 17741380
SGTC_1622 st003707 19.4 µM -0.10568784839012 0.476726926072108 no 1783 0.457915010964708 621 10140899
SGTC_87 0100-0052 35.5 µM -0.10629086937003 0.47649257489485 no 1784 0.457675787869714 590 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2060 5238662 140 µM -0.106824468330705 0.476285209874876 no 1785 0.457464117811425 613 790130
SGTC_1039 k821-0043 94 µM -0.107888024863815 0.475871914148536 no 1786 0.457042258223263 578 15992768
SGTC_477 mead ethanolamide 10 µM -0.108441152521186 0.475656980191299 no 1787 0.456822879298414 581 16061185
SGTC_2544 sphondin 68.51 µM -0.108849537611311 0.47549829474127 no 1788 0.456660915939188 583 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2696 st077691 74.316 µM -0.109714630860901 0.475162159900805 no 1789 0.456317848359485 608 757133
SGTC_1841 st054148 70 µM -0.110081306659227 0.47501969212831 no 1790 0.456172446587233 635 675442
SGTC_1047 2043-3044 82 µM -0.110310720914835 0.474930557413276 no 1791 0.456081477547157 627 669592
SGTC_331 k048-0133 24.5 µM -0.110828172309641 0.474729515747115 no 1792 0.455876302346364 594 6813582
SGTC_944 3370-0224 231 µM -0.111141215860787 0.47460789430983 no 1793 0.455752182824979 606 4580514
SGTC_3132 9126706 49.47 µM -0.112771353517057 0.473974603408997 no 1794 0.455105915008441 598 850858
SGTC_3108 9121785 49.47 µM -0.112838107712843 0.473948671514516 no 1795 0.455079452838425 578 17140271
SGTC_1632 st005650 90 µM -0.112919468361192 0.4739170656243 no 1796 0.455047200763603 599 2759605
SGTC_3204 9114183 49.47 µM -0.113412845511013 0.47372540862957 no 1797 0.45485162808682 603 17027248
SGTC_2232 chlorophetanol 41.5365 µM -0.114081519911331 0.473465665483802 no 1798 0.454586585774285 606 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2960 9079389 5.97 µM -0.114362335228074 0.47335658756954 no 1799 0.454475285095534 616 16457355
SGTC_541 4513-1321 94 µM -0.118026083551879 0.471933653154425 no 1800 0.453023495319696 589 747515
SGTC_1614 st002383 48.6 µM -0.118490585109708 0.471753274251023 no 1801 0.452839477269234 605 1947235
SGTC_1755 st041960 45.185 µM -0.120125615963252 0.471118392528325 no 1802 0.45219182035721 601 2257073
SGTC_3223 9129970 49.47 µM -0.121147207979584 0.470721745974578 no 1803 0.451787218974655 597 17248386
SGTC_2194 5927483 104.545 µM -0.121150331433082 0.470720533296962 no 1804 0.451785982007879 597 760979
SGTC_1753 st043925 64 µM -0.122536599732883 0.470182343016774 no 1805 0.451237030992489 605 670181
SGTC_2669 eugenol 100 µM -0.1247906971392 0.46930735257033 no 1806 0.450344626213378 620 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1677 st019204 53.9 µM -0.125285069882521 0.469115467744457 no 1807 0.450148935778957 609 3945625
SGTC_3233 9132340 49.47 µM -0.125926235605389 0.46886661768274 no 1808 0.449895157486513 649 17682950
SGTC_1516 st013856 110 µM -0.126803676164218 0.468526084059776 no 1809 0.449547893034926 633 5281404 A mutagen and neurotoxin.
SGTC_9 0092-0002 10.449 µM -0.127590694515393 0.468220662768658 no 1810 0.449236447820706 606 759368
SGTC_2099 5377090 177.372 µM -0.12874659191691 0.467772123100462 no 1811 0.448779083577844 621 2243829
SGTC_3151 9099821 49.47 µM -0.129609040504354 0.467437481261091 no 1812 0.448437875148404 641 17174189
SGTC_248 streptozotocin 5.23457 mM -0.130918826190517 0.466929310603405 no 1813 0.447919760858489 619 5300 DNA alkylating agent.
SGTC_3002 9075603 71.4286 µM -0.13150685456697 0.466701184832641 no 1814 0.44768718225349 603 20105405
SGTC_2735 sertaconazole 140 nM -0.132188662470008 0.466436690967994 no 1815 0.447417534232354 606 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3010 9080089 71.4286 µM -0.13245001827403 0.466335307086558 no 1816 0.447314177133338 618 17027233
SGTC_704 1310-0270 142 µM -0.133600319836605 0.465889113712781 no 1817 0.446859315631912 618 5718033
SGTC_1739 st037196 92.5 µM -0.135614631753272 0.465107880795004 no 1818 0.446062968926938 620 612214
SGTC_2572 astragaloside iv 100 µM -0.135996736877012 0.464959699811382 no 1819 0.445911930296824 606 45006101 An anti-inflammatory agent.
SGTC_1502 4534-4282 27.7 µM -0.136756457995193 0.4646650931907 no 1820 0.445611650837778 635 3278949
SGTC_204 PMA1.184 62.41 µM -0.136971880494765 0.464581559614349 no 1821 0.445526510853257 609 2252213 YGL008C PMA1
SGTC_2215 7188065 200 µM -0.137924424358797 0.464212214007294 no 1822 0.445150073519261 609 940217
SGTC_1659 st012954 42.1 µM -0.13936320090219 0.463654391920368 no 1823 0.444581574983481 635 24207262
SGTC_3143 9086658 49.47 µM -0.141751356200585 0.462728648378073 no 1824 0.443638204045458 617 25236626
SGTC_151 3013-0144 2.285 µM -0.141848229492601 0.462691100680654 no 1825 0.443599943786494 635 906558 YHR107C CDC12
SGTC_919 tnp00227 403.569 nM -0.142479444379452 0.462446452490242 no 1826 0.443350657364003 637 1269246 A methoxyflavone. YNL221C POP1
SGTC_660 4031-1742 102 µM -0.147045467814199 0.460677167943401 no 1827 0.441548066114953 601 6738706
SGTC_3015 9080845 49.47 µM -0.148904266243543 0.459957124612135 no 1828 0.440814587386151 641 5296973
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.150952347296988 0.459163910941476 no 1829 0.440006653194187 604 97141
SGTC_1439 4092-1168 46 µM -0.151561630810472 0.458927969080411 no 1830 0.439766348948208 612 2886240
SGTC_132 0417-1715 25.805 µM -0.15196702106678 0.458770991829371 no 1831 0.439606473437589 624 6769098
SGTC_2665 lovastatin 100 µM -0.152276728020512 0.458651069877938 no 1832 0.439484339600302 614 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1760 st045453 10.4495 µM -0.153292588911078 0.45825774379967 no 1833 0.439083772397817 610 3323419 YIL048W NEO1
SGTC_54 0159-0055 9 µM -0.155025030222698 0.457587063033369 no 1834 0.438400792292374 687 3319099
SGTC_2327 6189656 200 µM -0.155235014608222 0.457505779853618 no 1835 0.438318022598665 642 5349088
SGTC_2010 4012422 159 µM -0.157800451438938 0.456512865482116 no 1836 0.437307021458897 629 952393
SGTC_2110 5483698 200 µM -0.158993427969163 0.456051233658106 no 1837 0.436837025844904 610 2848765 YHR062C RPP1
SGTC_1229 0139-0193 12.2 µM -0.159822015741961 0.455730639853231 no 1838 0.436510640474475 608 3090752
SGTC_2924 9010168 62.78 µM -0.160851751000455 0.455332259073486 no 1839 0.436105082236557 632 2993929
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.161685008318264 0.455009923926621 no 1840 0.435776955412331 675 6710655
SGTC_1777 st045864 34.765 µM -0.162562932855192 0.454670341873177 no 1841 0.435431286994458 623 4691462
SGTC_2522 biochanin a 4.94 µM -0.163937246446493 0.45413882266503 no 1842 0.434890272660694 643 5280373 A possible chelator.
SGTC_1274 0865-0114 173 µM -0.164092875501815 0.454078637898363 no 1843 0.434829015158858 615 870624
SGTC_738 1315-0003 72.4 µM -0.164163019269194 0.454051512291072 no 1844 0.434801406224456 656 6251474
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.164735100843873 0.453830288102005 no 1845 0.434576243963716 631 16486 A toxic proline analog.
SGTC_2893 9048488 25.97 µM -0.16515970102944 0.453666104286297 no 1846 0.434409141760044 601 6467338
SGTC_2867 9039098 71.43 µM -0.165404262865638 0.453571541044029 no 1847 0.434312899304771 623 6463460
SGTC_2406 ethylparaben 405.7 µM -0.165470861691024 0.453545790135839 no 1848 0.434286691333443 670 8434 A possible steroid mimic.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.166114939605485 0.45329676293613 no 1849 0.43403324869705 638 5282362
SGTC_1741 st038134 10.228 µM -0.166532342874998 0.453135387344014 no 1850 0.433869016294967 631 1272587
SGTC_2225 6654152 15.4 µM -0.168464406368047 0.452388518171608 no 1851 0.43310897152378 644 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2833 9001315 45.46 µM -0.168954335597053 0.452199155080564 no 1852 0.432916279924199 610 2989378
SGTC_350 k064-0020 19.8 µM -0.16941369875231 0.452021615992666 no 1853 0.432735624600367 638 2790705
SGTC_513 4245-1575 41.7 µM -0.169688147848217 0.45191554884394 no 1854 0.432627697769371 614 719745
SGTC_361 000s-0510 1.45 µM -0.170124507344479 0.451746914776406 no 1855 0.43245611018791 633 660
SGTC_2730 imipramine 71.33 µM -0.171338935589618 0.451277636724894 no 1856 0.431978633464636 633 3696 A tricyclic antidepressant.
SGTC_1146 3579-1023 7 µM -0.171396036720912 0.451255573438181 no 1857 0.431956185454206 623 X1146
SGTC_251 melphalan 456.522 µM -0.171640821369912 0.451160992888138 no 1858 0.431859956430013 637 460612 A DNA alkylator.
SGTC_1930 st074634 34.3 µM -0.171681435422897 0.451145300589315 no 1859 0.431843990743369 644 684253 YOR116C RPO31
SGTC_495 decylubiquinone 155 µM -0.171898015395398 0.451061620557049 no 1860 0.431758853423802 658 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_270 tamoxifen 5.46 µM -0.172446821967681 0.45084958783653 no 1861 0.431543132438963 638 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1503 4585-0012 61.3 µM -0.172622668742252 0.450781651982194 no 1862 0.431474016154845 640 2922052
SGTC_829 1635-0120 117 µM -0.17308807619413 0.450601855517557 no 1863 0.431291098655003 616 285054
SGTC_760 0568-0725 82.9 µM -0.17347105163751 0.450453911832971 no 1864 0.431140590175042 645 3916171
SGTC_233 rapamycin 362 pM -0.175164280405685 0.449799899142285 no 1865 0.430475275233039 617 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_106 0092-0003 11.579 µM -0.17565647501037 0.449609813576494 no 1866 0.430281915717099 636 1072148
SGTC_2307 7538926 6.34 µM -0.176265004451394 0.449374815483786 no 1867 0.430042876971305 623 96582
SGTC_3116 9124943 49.47 µM -0.176596576732951 0.449246778442022 no 1868 0.429912641597616 598 41905195 YPL160W CDC60
SGTC_554 4483-2211 187 µM -0.176783743657665 0.449174506037898 no 1869 0.429839129306138 622 747107
SGTC_2133 5320837 200 µM -0.176991950150402 0.449094111422406 no 1870 0.429757356303286 653 2841355
SGTC_786 4544-0069 423 µM -0.177568925919231 0.448871335135856 no 1871 0.429530765095549 620 748821 YLR208W SEC13
SGTC_611 3453-1652 23.7 µM -0.177700231406705 0.44882063898386 no 1872 0.429479201752285 627 1560575
SGTC_830 4076-0286 57.8 µM -0.178408963168303 0.448547016939063 no 1873 0.42920090532015 620 6866659
SGTC_3347 9188721 44.724 µM -0.178520983034626 0.448503771353822 no 1874 0.429156921896556 638 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1859 st055998 20 µM -0.179891198376715 0.447974845530124 no 1875 0.428618992579775 658 676301
SGTC_1206 3978-0017 132 µM -0.180531644585454 0.447727654341582 no 1876 0.428367606856259 665 3873677
SGTC_503 tyrphostin 8 294 µM -0.180581038029123 0.447708590937556 no 1877 0.428348220319055 670 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_881 0833-0569 170 µM -0.180735051717909 0.44764915011619 no 1878 0.428287772270901 612 5418700
SGTC_3031 9088762 49.47 µM -0.181587202927357 0.44732028785589 no 1879 0.427953346231411 633 205253
SGTC_2732 terfenadine 20 µM -0.18191669523398 0.447193139855748 no 1880 0.427824051106424 622 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1578 josamycin 24.2 µM -0.182345700691303 0.447027598796549 no 1881 0.427655717929301 653 5282165 A P450 substrate.
SGTC_1302 1159-0335 255 µM -0.182974603839593 0.446784939567443 no 1882 0.427408972697822 643 649284
SGTC_1721 st082152 9.2685 µM -0.183440426583626 0.446605216959706 no 1883 0.427226229085413 628 5296051
SGTC_1297 1068-0111 14.1 µM -0.1866794919937 0.445355833802246 no 1884 0.425955968220444 614 767057
SGTC_2017 5132927 60.65 µM -0.187064591002848 0.445207327966543 no 1885 0.42580499516974 643 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1078 idebenone 36.1 µM -0.187207153608528 0.44515235345908 no 1886 0.425749108114133 621 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3334 9142812 21.919 µM -0.187588266182246 0.44500539530541 no 1887 0.425599712590392 636 45283678
SGTC_2931 9014674 55.67 µM -0.188168879890581 0.444781523449306 no 1888 0.425372133475412 634 2996810
SGTC_794 k038-0031 316 µM -0.188948164770075 0.444481076061264 no 1889 0.425066721696085 617 6624242
SGTC_745 0469-0705 296 µM -0.190495526456809 0.443884597186721 no 1890 0.424460424187831 653 3486736
SGTC_2129 girgensonine 121.053 µM -0.190596703041215 0.443845599925619 no 1891 0.424420786716913 647 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1245 0418-0076 17.2 µM -0.19210038246652 0.443266089612725 no 1892 0.423831787663024 684 6790114
SGTC_1573 oleylamine 1.06 µM -0.198544047772133 0.44078412322902 no 1893 0.421309712742346 658 5356789 An amine of the fatty acid oleic acid.
SGTC_3219 9131112 49.47 µM -0.201412546425532 0.439679978815415 no 1894 0.42018800280185 622 17612988 YMR079W SEC14
SGTC_1162 k048-0130 20.1 µM -0.201690098106088 0.439573168188059 no 1895 0.420079502045052 658 6797406
SGTC_848 0368-0089 85.6 µM -0.202685610500435 0.43919009990413 no 1896 0.419690385446943 665 762535
SGTC_380 3970-0968 6 µM -0.205928935186215 0.437942481265205 no 1897 0.41842321140512 628 2891601
SGTC_701 4424-0219 185 µM -0.206005067215414 0.43791320270661 no 1898 0.418393476568068 658 2911779
SGTC_1497 4476-2978 41.3 µM -0.206055475562486 0.437893817048289 no 1899 0.418373788869389 623 1528379
SGTC_2728 chlorpromazine 9.18 µM -0.207073712202329 0.437502263331338 no 1900 0.417976145882263 626 2726 A thorazine and dopamine antagonist.
SGTC_801 0866-0028 10.1 µM -0.207683460805383 0.437267819275932 no 1901 0.417738066237636 620 6849771
SGTC_1487 3970-0795 2.82 µM -0.209008817186818 0.436758305132605 no 1902 0.417220677755044 642 3765103
SGTC_13 0199-0087 65 µM -0.210163178013333 0.436314613199931 no 1903 0.416770158714581 630 4589825
SGTC_2769 toremifene 3.73 µM -0.210191221446599 0.436303835376685 no 1904 0.416759215399932 636 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_985 1493-0307 8.71 µM -0.210253273809406 0.436279987202405 no 1905 0.41673500110012 664 3278274
SGTC_747 3448-8087 38.7 µM -0.21033223529744 0.436249640790766 no 1906 0.416704188916446 671 5168703
SGTC_1724 st037281 8.293 µM -0.214180559362591 0.434771114365593 no 1907 0.415203127852201 637 574124 YDL195W SEC31
SGTC_1278 0874-0585 172 µM -0.215509026553674 0.43426092780094 no 1908 0.414685237614846 635 766306
SGTC_472 calcifediol 10 µM -0.216420635009507 0.433910895583953 no 1909 0.414329941487655 625 5283731 A vitamin D metabolite.
SGTC_1177 0983-0204 23.6 µM -0.216611047692783 0.43383778895841 no 1910 0.414255737666673 622 766818
SGTC_2702 st077768 96.8 µM -0.217098469844192 0.433650659490436 no 1911 0.414065803209114 629 6484119
SGTC_2984 9022109 38.96 µM -0.217266795274434 0.433586040011595 no 1912 0.414000216274531 653 6459207
SGTC_1112 tnp00069 1.16933 µM -0.217370410566939 0.433546263385879 no 1913 0.413959844426596 656 145826
SGTC_2762 leflunomide 42.06 µM -0.217435874696701 0.433521132865301 no 1914 0.413934337966458 641 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2681 menadione 3.18 µM -0.217795787421302 0.433382973544857 no 1915 0.413794113466824 642 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.218423989098409 0.433141845939367 no 1916 0.413549388071565 628 115019
SGTC_2862 9027634 71.43 µM -0.219043401078767 0.432904116520109 no 1917 0.413308119710318 624 5012562
SGTC_486 niguldipine 82 µM -0.220503267157086 0.432343918238561 no 1918 0.412739614085997 623 1236 A calcium channel blocker.
SGTC_1025 k007-0731 70 µM -0.221517186688341 0.431954924158209 no 1919 0.41234487796675 622 6256118
SGTC_781 4335-2806 94.4 µM -0.222898890954712 0.431424934329717 no 1920 0.411807099783288 680 845254
SGTC_442 cape 100 µM -0.223493869908288 0.431196752115565 no 1921 0.411575576794217 659 5281787
SGTC_1928 4'-methoxychalcone 40.3 µM -0.223801266520013 0.431078870484025 no 1922 0.411455972211914 682 641818
SGTC_1959 st077091 55.8 µM -0.224779969215919 0.430703594761271 no 1923 0.41107522479663 643 821356 YKL052C ASK1
SGTC_1462 k081-0014 26.5 µM -0.225228545255457 0.430531612755763 no 1924 0.41090074198956 669 3270634
SGTC_2727 riluzole 51.77 µM -0.225304490262963 0.43050249708989 no 1925 0.410871203372579 646 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_557 1315-0110 16.2 µM -0.225517679353143 0.430420767043879 no 1926 0.410788286720981 639 6833801
SGTC_2343 7990716 14.84 µM -0.225774584226821 0.430322281690669 no 1927 0.410688372777447 615 6456862
SGTC_1158 4092-0494 91.8 µM -0.227373611229019 0.429709386954845 no 1928 0.41006661906448 680 1148199
SGTC_1678 st019265 80.2 µM -0.228595240371822 0.429241259953703 no 1929 0.409591762129801 682 5367020
SGTC_2988 9073640 71.4286 µM -0.230941473631299 0.428342465432913 no 1930 0.40868013509491 676 9102229
SGTC_2914 7968218 45.32 µM -0.231519458598291 0.428121107942612 no 1931 0.408455635130408 679 2977111
SGTC_3283 9109332 35.8195 µM -0.232702255721734 0.427668189219239 no 1932 0.407996308742271 649 17027281
SGTC_1254 0550-0035 264 µM -0.233347721076202 0.42742106666218 no 1933 0.407745702571983 677 15121435
SGTC_1940 st075990 51.1 µM -0.233467959068654 0.427375035545155 no 1934 0.407699023547676 669 1084979
SGTC_1847 st056231 15 µM -0.233633766223235 0.427311560653646 no 1935 0.40763465572524 645 5393180
SGTC_702 1488-0190 94 µM -0.23444596800191 0.42700065786095 no 1936 0.407319387773931 638 949357
SGTC_2874 9043904 71.43 µM -0.235455774423394 0.426614177219034 no 1937 0.406927500434027 655 4463428
SGTC_3059 1327-0034 3 µM -0.235706686223745 0.426518157297229 no 1938 0.406830140605191 649 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1581 himbacine 57.9 µM -0.235711213215031 0.426516424930249 no 1939 0.406828384076273 686 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1837 st055472 66.5 µM -0.236242128598179 0.426313266658147 no 1940 0.406622395313867 655 676091
SGTC_1880 MG-132 525 µM -0.237041719224583 0.426007334945972 no 1941 0.406312212569649 660 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_705 1124-0212 310 µM -0.237499527568051 0.42583219273343 no 1942 0.406134642832575 643 9554485
SGTC_3195 9113082 49.47 µM -0.237920018047032 0.425671339981362 no 1943 0.405971564552918 634 17018038
SGTC_877 0771-0151 33.1 µM -0.23838091163231 0.425495045795412 no 1944 0.405792835530371 670 6166523
SGTC_2286 7945697 125 µM -0.239025376873087 0.425248559481079 no 1945 0.405542952546496 666 1245733
SGTC_2185 6113692 200 µM -0.240610592226652 0.424642392344973 no 1946 0.404928469965426 655 874150
SGTC_1545 lovastatin 49.4 µM -0.240709088065393 0.424604734594579 no 1947 0.404890297395684 631 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_777 1315-0167 517 µM -0.241500511662448 0.424302175933242 no 1948 0.404583609984175 641 4221767
SGTC_3272 9137413 49.47 µM -0.242034910853111 0.424097902081052 no 1949 0.404376556166088 688 17614870
SGTC_1053 3366-3204 134 µM -0.242452699007135 0.423938216944411 no 1950 0.40421470212876 652 3632071 YPR165W RHO1
SGTC_1414 3917-0015 5.4 µM -0.24308061394811 0.42369824157512 no 1951 0.403971474356293 660 6618702
SGTC_2141 5621638 7.665 µM -0.243520746949902 0.423530049222112 no 1952 0.40380100751362 681 2856238
SGTC_2492 derrusnin 100 µM -0.243531216150291 0.423526048693113 no 1953 0.403796952935408 687 1715307 Part of coumarin class of compounds.
SGTC_1657 st012939 43.4 µM -0.244284642743896 0.423238167300047 no 1954 0.403505188281279 646 24207257
SGTC_3187 9109394 49.47 µM -0.244802678063304 0.423040251768392 no 1955 0.403304610104579 644 17098090
SGTC_2837 9008476 45.46 µM -0.244826448712856 0.423031170651048 no 1956 0.403295406952993 709 2992805
SGTC_2014 4013930 200 µM -0.244966250169699 0.422977763033519 no 1957 0.403241281876169 689 64556
SGTC_2482 5981709 142.65 µM -0.246415566763484 0.422424171792765 no 1958 0.402680278578903 676 877755
SGTC_1863 st057641 20.1 µM -0.248067311971848 0.421793446328971 no 1959 0.402041163260322 653 3921635
SGTC_1063 disulfiram 1.84 µM -0.24859627798881 0.421591500877895 no 1960 0.401836543934574 643 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1649 st011737 51.3 µM -0.249775185477299 0.421141498962596 no 1961 0.401380605367364 644 1761035
SGTC_998 3996-0085 177 µM -0.25054496251993 0.420847722170431 no 1962 0.401082969049831 637 715391
SGTC_1463 k081-0032 34.1 µM -0.250556789253271 0.420843208973374 no 1963 0.401078396659565 669 977755
SGTC_417 st075190 100 µM -0.25123744571002 0.42058348136292 no 1964 0.400815267640943 673 222757
SGTC_1010 4112-3296 15.2 µM -0.252093884673266 0.420256727088156 no 1965 0.400484248339272 672 704384
SGTC_2203 7227154 166.4 µM -0.252352937305923 0.420157902423298 no 1966 0.400384136856215 651 896304
SGTC_2683 piperine 63.03 µM -0.252436596655513 0.420125988720537 no 1967 0.400351807906693 671 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3221 9128209 49.47 µM -0.253289910682424 0.419800503309752 no 1968 0.400022096037402 660 16460723
SGTC_365 0121-0052 13.6 µM -0.253518162258356 0.419713449038166 no 1969 0.399933914017542 649 3101739
SGTC_1788 fluconazole 20 µM -0.256011633678801 0.418762705427896 no 1970 0.398970927114799 680 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1937 st074714 47.2 µM -0.26002540514952 0.417233280244325 no 1971 0.39742208848694 677 17250970
SGTC_663 1486-0733 13.9 µM -0.260085519833009 0.417210383335226 no 1972 0.397398903587647 672 722445 YPR165W RHO1
SGTC_1688 st021091 57.6 µM -0.261270308260061 0.416759170067672 no 1973 0.396942031059609 689 3656366
SGTC_2387 9077560 195.08 µM -0.261649182791959 0.41661490309702 no 1974 0.396795961059176 642 5303272
SGTC_3012 9080433 71.4286 µM -0.26183734728571 0.416543258427519 no 1975 0.396723422139273 667 17688859
SGTC_397 arbidol 50 µM -0.26206459400917 0.416456736679403 no 1976 0.396635821471227 652 131410 A RNA synthesis inhibitor.
SGTC_1180 1193-0155 285 µM -0.262234558248019 0.416392027267327 no 1977 0.396570305868703 685 2921347
SGTC_4 0960-0234 25.671 µM -0.262637820705271 0.416238504765874 no 1978 0.396414873191728 642 6821112
SGTC_728 3030-5151 22.5 µM -0.262711961221387 0.416210280772368 no 1979 0.396386298409846 657 3125388
SGTC_898 1000-0849 28.3 µM -0.263503979786167 0.415908800192752 no 1980 0.396081078243729 667 6751807
SGTC_594 1487-1584 10.8 µM -0.263513321593643 0.415905244543825 no 1981 0.396077478571421 697 5013332
SGTC_308 4092-1169 104 µM -0.264154756019882 0.415661120299969 no 1982 0.395830336289676 660 2268590 YDL196W YDL196W
SGTC_1909 st060837 51.5 µM -0.264795836589107 0.415417163250043 no 1983 0.395583372184787 698 678937
SGTC_2033 5192550 145 µM -0.265257542984633 0.415241485507565 no 1984 0.395405534532744 643 182073
SGTC_824 1304-0008 100 µM -0.266303473725755 0.414843575073514 no 1985 0.39500274901168 656 768245
SGTC_826 1683-5028 118 µM -0.266577958423954 0.414739165475517 no 1986 0.394897064151218 686 722377
SGTC_1872 amphotericin b 148 nM -0.26999567881243 0.413439625857143 no 1987 0.393581789002441 673 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1111 tnp00062 510.699 nM -0.270301235040767 0.413323488383086 no 1988 0.393464257643339 654 676306
SGTC_3200 9114385 49.47 µM -0.2706547562935 0.413189129564836 no 1989 0.393328288782743 681 17018030 YLR208W SEC13
SGTC_1531 st059297 52.4 µM -0.272770530672936 0.412385224187515 no 1990 0.392514806965575 659 7566702
SGTC_2031 5180455 200 µM -0.273051131434523 0.412278635210545 no 1991 0.392406955583805 665 29949
SGTC_491 tetrandrine 80.3 µM -0.273410683189213 0.412142065375012 no 1992 0.392268770768954 682 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2436 5633522 8.09 µM -0.273989105337376 0.411922383542422 no 1993 0.392046497047906 693 5724242
SGTC_894 0960-0238 55.9 µM -0.27474768902087 0.411634319106379 no 1994 0.391755044981005 679 6741907 YDL195W SEC31
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.275740998449752 0.411257191983972 no 1995 0.391373501838792 657 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2664 lyso-paf C-16 73.48 µM -0.276970987982643 0.410790318818103 no 1996 0.390901191612129 669 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2691 st077356 60.2 µM -0.277856617942764 0.410454234111286 no 1997 0.390561213432251 685 2839272
SGTC_957 1187-1561 14.1 µM -0.28012265019659 0.409594605105946 no 1998 0.389691703865052 680 1538454
SGTC_1699 st031318 29.054 µM -0.280380613524929 0.409496773082772 no 1999 0.389592754484456 683 5340658
SGTC_3009 9080819 71.4286 µM -0.280675035081364 0.409385121243808 no 2000 0.389479829229518 683 17027216
SGTC_2118 5526350 200 µM -0.283277079301406 0.408398683078321 no 2001 0.388482223026523 687 743594
SGTC_803 4488-1585 147 µM -0.283537548596855 0.408299970688616 no 2002 0.388382401226368 687 747204
SGTC_260 nsc-65238 3.989 µM -0.284022683571985 0.408116130243368 no 2003 0.388196498598213 667 3246252
SGTC_2305 7443522 69.23 µM -0.284884922003161 0.407789437513853 no 2004 0.387866154018685 669 5415886
SGTC_359 0081-0058 15.9 µM -0.285320873379713 0.407624284681871 no 2005 0.387699161277779 703 3494159
SGTC_2444 5485484 36.41 µM -0.285421702985342 0.407586089421445 no 2006 0.387660541091533 711 6790631
SGTC_24 0417-1663 219 µM -0.285913806176818 0.407399688436401 no 2007 0.387472069580984 696 4329390
SGTC_3317 9138495 8.753 µM -0.286593673542054 0.407142199821608 no 2008 0.387211729553308 659 17020139
SGTC_1412 3909-8563 178 µM -0.28773044065092 0.406711757608767 no 2009 0.386776543330822 681 23767530
SGTC_1218 1348-1416 30.7 µM -0.288860422516672 0.4062839963293 no 2010 0.386344095734849 671 6787668
SGTC_3061 glucosamine 200 µM -0.288963807806848 0.406244864796116 no 2011 0.386304536900068 660 91431 and experimental redox chemotherapeutic
SGTC_3253 9135987 49.47 µM -0.289369523818518 0.406091309549478 no 2012 0.386149307159555 681 4182430
SGTC_3273 9137859 49.47 µM -0.289577331488304 0.406012664171759 no 2013 0.386069805569677 662 2377234
SGTC_1455 4262-0120 131 µM -0.289828336819706 0.40591767557889 no 2014 0.385973784102981 667 1529587
SGTC_2720 fluspirilene 36.88 µM -0.290120959692589 0.405806944545361 no 2015 0.385861850767864 687 3396 An atypical antipsychotic.
SGTC_3038 9091290 49.47 µM -0.290305204969009 0.405737228400177 no 2016 0.385791378621631 702 25236843
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.291461886034022 0.405299622905291 no 2017 0.385349044808846 661 6708561
SGTC_1748 st037455 53.6035 µM -0.291911099373627 0.405129704543779 no 2018 0.385177298425559 695 580690
SGTC_194 1486-1323 56.904 µM -0.293214589831534 0.404636750704538 no 2019 0.3846790664385 657 5178754
SGTC_875 0709-0210 25.7 µM -0.29509714590899 0.403925073188682 no 2020 0.383959834965981 712 6251364
SGTC_2959 9079155 11 µM -0.295175409839093 0.403895493324996 no 2021 0.383929942825389 690 16189457
SGTC_855 0428-0020 25 µM -0.296983961567568 0.403212104356416 no 2022 0.383239376925469 665 6812414
SGTC_2089 5281248 129.67 µM -0.297522683748444 0.403008596954788 no 2023 0.383033746256516 662 2737878
SGTC_167 3672-0051 66.205 µM -0.298706891818963 0.402561343565647 no 2024 0.382581849049687 687 3237971
SGTC_2614 arthonioic acid 13.39 µM -0.299260131484161 0.402352438883378 no 2025 0.382370785940664 689 6710684
SGTC_1906 st060206 94.7 µM -0.299424673812624 0.40229031266567 no 2026 0.382308019133729 704 5133468
SGTC_2111 5486399 200 µM -0.30016799786282 0.402009686717083 no 2027 0.382024507088021 664 689674
SGTC_319 1348-1596 45.5 µM -0.30030775808729 0.401956928898154 no 2028 0.381971208046606 715 5380505
SGTC_145 3737-0113 38.366 µM -0.300437968278624 0.401907777710384 no 2029 0.381921553024336 676 6849351
SGTC_347 4534-1311 26.2 µM -0.301470092439655 0.401518230829956 no 2030 0.381528026287362 683 2862016
SGTC_3288 9119690 36.221 µM -0.301477239930277 0.40151553354689 no 2031 0.381525301529369 705 17595618 YKL019W RAM2
SGTC_117 lucigenin 22.078 µM -0.301883491483535 0.401362232152365 no 2032 0.381370440443316 708 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_719 2810-4230 27.3 µM -0.30196928395184 0.401329859804587 no 2033 0.381337739206008 669 721079
SGTC_2673 kobusone 100 µM -0.305346363034449 0.400056115904587 no 2034 0.380051184136287 673 6710676 An epoxy ketone and protein crosslinker.
SGTC_2278 7948257 134.34 µM -0.305415132900381 0.400030188744004 no 2035 0.380024998830128 696 1247028
SGTC_1820 st053765 18.6 µM -0.306188541696485 0.399738633639493 no 2036 0.379730548062977 677 3690829
SGTC_65 0798-0905 34.986 µM -0.30863527350886 0.39881664787608 no 2037 0.378799492776617 771 3602145
SGTC_2773 thioridazine 9.09 µM -0.309180065138443 0.398611434285082 no 2038 0.378592278611598 678 5452 An antipsychotic.
SGTC_1386 3228-0095 33.8 µM -0.309707622467523 0.398412739270146 no 2039 0.378391652857977 721 870181
SGTC_3236 9132701 49.47 µM -0.310144460786002 0.398248231873098 no 2040 0.378225551609999 703 24282524
SGTC_3058 9093861 49.47 µM -0.310878193138954 0.397971958911218 no 2041 0.37794661149288 715 17217477
SGTC_3033 9090887 49.47 µM -0.312435710682233 0.397385674994218 no 2042 0.377354707254658 669 19325384
SGTC_454 lyso-paf C-16 6.67 µM -0.3135320815052 0.396973115765123 no 2043 0.376938225474964 713 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1326 1431-2094 10.8 µM -0.313860220127963 0.396849661123695 no 2044 0.376813602251303 703 616278
SGTC_2521 angolensin 13.4 µM -0.314284947377684 0.39668988257461 no 2045 0.376652314851809 675 821428 A flavenoid.
SGTC_1658 st012944 20 µM -0.319517604839284 0.394722835197325 no 2046 0.374667021874267 708 24207260
SGTC_2715 st079500 56.4 µM -0.320477559575368 0.394362260984476 no 2047 0.374303169456597 690 28246688
SGTC_1846 st056244 14.8 µM -0.322098704139907 0.393753539011907 no 2048 0.373688959980137 697 5393182
SGTC_60 0986-0278 202 µM -0.323002007774999 0.393414470917158 no 2049 0.373346860757843 740 3110598
SGTC_2257 7960413 200 µM -0.323008141457424 0.393412168826642 no 2050 0.373344538150012 676 2974689 YIL048W NEO1
SGTC_1481 3346-2004 36 µM -0.324138547807866 0.392987969004573 no 2051 0.372916572038526 716 2770522
SGTC_2663 amphotericin b 100 µM -0.324601362237784 0.392814328441789 no 2052 0.372741398050137 688 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_952 1185-0122 232 µM -0.325438109665876 0.392500448366993 no 2053 0.372424758268344 690 678600
SGTC_1389 3405-0187 19 µM -0.326291936010463 0.392180233727923 no 2054 0.372101744398618 674 799890
SGTC_1225 1216-0074 20.6 µM -0.327844939037622 0.391597990745563 no 2055 0.371514453498472 688 4241466
SGTC_2705 st078069 42.8 µM -0.328526717373071 0.391342458924549 no 2056 0.371256723359567 709 1530061
SGTC_1960 st011366 51.8 µM -0.328718027169807 0.39127076406738 no 2057 0.371184413591828 670 3972846
SGTC_421 streptovitacin 30 mM -0.328946365162066 0.391185197437496 no 2058 0.371098114151603 697 91467 include heat shock
SGTC_1552 6-methylflavone 10.6 µM -0.329164865177915 0.391103322389489 no 2059 0.371015539004465 684 689013
SGTC_2145 5634607 200 µM -0.329647660023807 0.390922429445447 no 2060 0.370833103077011 711 308662
SGTC_3303 9125618 40.5795 µM -0.33080770368169 0.390487882338808 no 2061 0.370394870759338 702 22695467
SGTC_548 1436-0017 110 µM -0.332366418909688 0.389904210082276 no 2062 0.369806296221383 702 9677137
SGTC_3052 9092717 49.47 µM -0.332416534851206 0.389885447914162 no 2063 0.369787377375324 708 25237534
SGTC_124 0136-0217 7.121 µM -0.333344457129525 0.389538103176265 no 2064 0.369437142255435 718 3976905
SGTC_993 3909-8757 62.7 µM -0.333773415596387 0.389377562992279 no 2065 0.369275272703099 672 4288324 YLR208W SEC13
SGTC_843 0310-0051 143 µM -0.334041775768457 0.389277137245668 no 2066 0.369174017476358 712 2065037
SGTC_1603 st002045 67.8 µM -0.334219682207954 0.389210565171726 no 2067 0.369106896434464 699 5887985
SGTC_1956 st077085 54 µM -0.334593898839904 0.389070545009067 no 2068 0.368965723959382 696 24208685
SGTC_709 3807-1509 243 µM -0.335205161395992 0.388841860663718 no 2069 0.368735164407747 718 1886677 YPL242C IQG1
SGTC_2465 5809242 33.21 µM -0.335941197722232 0.388566547310793 no 2070 0.368457604653351 716 2731748
SGTC_1318 1280-3875 124 µM -0.33617702018906 0.388478350080663 no 2071 0.368368690363964 715 373245
SGTC_3276 9139060 49.47 µM -0.337369317365393 0.388032520927176 no 2072 0.367919255715469 722 4870619
SGTC_2184 6075246 200 µM -0.339413201115013 0.387268606179217 no 2073 0.36714923758068 678 2267320
SGTC_1426 4048-4480 71.7 µM -0.340073355083437 0.387021962456047 no 2074 0.366900643393513 701 14224343
SGTC_2294 7971431 200 µM -0.343043464567944 0.385912849240724 no 2075 0.365782880932852 737 5741572
SGTC_1557 sumaresinolic acid 42.3 µM -0.344145867251906 0.385501421140717 no 2076 0.365368295066398 701 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1907 st060210 83.7 µM -0.344891371018978 0.385223264390225 no 2077 0.3650880189929 703 688793
SGTC_2053 5265679 138 µM -0.346071693041179 0.384782992313597 no 2078 0.364644418107423 675 764595
SGTC_1864 st057645 30.4 µM -0.347459175774985 0.384265637147901 no 2079 0.364123191619801 711 688666
SGTC_989 1501-0895 10.3 µM -0.349256678492446 0.383595703097727 no 2080 0.363448309305018 721 2830112
SGTC_128 0906-2981 13.371 µM -0.349813039378465 0.383388416310846 no 2081 0.363239506287851 730 6740226
SGTC_2235 salicylic acid 500 µM -0.350184958961863 0.383249866560447 no 2082 0.363099947006172 697 338 A COX inhibitor and kinase inhibitor.
SGTC_3079 9117512 49.47 µM -0.352566010143339 0.382363217353339 no 2083 0.362206911593257 717 7185044
SGTC_3327 9140648 26.9345 µM -0.353022439948204 0.382193323557531 no 2084 0.362035808801601 712 8029710
SGTC_2938 9059746 27.26 µM -0.353271143184388 0.382100759968388 no 2085 0.361942588502502 719 6471769
SGTC_2864 9034755 47.6 µM -0.35513139997483 0.381408614518499 no 2086 0.361245577018568 685 4930451
SGTC_1459 k035-0031 35.7 µM -0.356103281176829 0.381047157456644 no 2087 0.360881610033638 681 3877128 YMR208W ERG12
SGTC_3053 9095903 49.47 µM -0.356134875915862 0.381035408643497 no 2088 0.360869779998028 735 17174018
SGTC_746 1095-0025 46.6 µM -0.356633381283998 0.380850049062695 no 2089 0.360683141983045 715 6749286
SGTC_2854 9024559 71.43 µM -0.356850388378515 0.380769367710573 no 2090 0.360601905932122 728 3163529
SGTC_1277 0873-0036 22 µM -0.357439511355538 0.380550363058317 no 2091 0.360381400981168 708 5965735
SGTC_2037 5169046 200 µM -0.357658525495738 0.380468954982362 no 2092 0.360299437228441 700 5718022
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.360147353741749 0.379544224284935 no 2093 0.359368471116779 709 688801
SGTC_440 fluspirilene 35.1 µM -0.360445460154347 0.379433508136354 no 2094 0.359257017866256 709 3396 An atypical antipsychotic.
SGTC_1299 1079-1439 3.74 µM -0.36066642672516 0.379351447956119 no 2095 0.359174412669139 719 323161
SGTC_1978 st071761 42 µM -0.361081933992317 0.379197156073914 no 2096 0.359019099041331 687 5147680
SGTC_1077 5-fluorocytosine 377 nM -0.36139202892802 0.379082019887931 no 2097 0.358903202966869 730 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_61 0978-8327 98.565 µM -0.362835209147311 0.378546317956148 no 2098 0.358363994265018 731 6150059 YHR072W ERG7
SGTC_3027 9089541 49.47 µM -0.363971145372883 0.378124827629282 no 2099 0.357939778186845 704 9943819
SGTC_2655 perillic acid 100 µM -0.364041066523747 0.378098888045603 no 2100 0.357913671814519 706 5702197 An apoptosis inducer.
SGTC_1558 st069300 45.6 µM -0.365441448518279 0.37757948548096 no 2101 0.357390953023435 723 24208000
SGTC_229 benomyl 22.8748 µM -0.367383968083924 0.376859370317847 no 2102 0.356666314205275 707 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1824 st053723 68.6 µM -0.36851590858792 0.376439943756775 no 2103 0.356244292586879 722 675225
SGTC_2074 5212007 75.395 µM -0.370584620354093 0.375673785332148 no 2104 0.355473469435821 687 758611
SGTC_3228 9131799 49.47 µM -0.370589564384663 0.375671954869794 no 2105 0.355471627945919 706 17015818
SGTC_2731 amoxapine 43.43 µM -0.371771836514067 0.375234314579101 no 2106 0.355031367154202 720 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1650 st011916 45.8 µM -0.372035464314339 0.375136749656389 no 2107 0.35493322239116 737 242528
SGTC_1850 st056238 17 µM -0.372297078411438 0.375039937873612 no 2108 0.354835836815709 711 5393177
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.372852639559702 0.374834375431018 no 2109 0.354629061220553 754 5282309
SGTC_1749 st037932 54.2 µM -0.373130185407732 0.374731694375245 no 2110 0.354525776825042 734 594497
SGTC_1118 chelidonine 707.474 nM -0.373674060449894 0.374530507742817 no 2111 0.354323413159738 733 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1727 st034309 9.9045 µM -0.374346216764542 0.374281915347197 no 2112 0.354073375740586 736 870305
SGTC_1831 st055328 12 µM -0.374558308490252 0.374203485521248 no 2113 0.353994492162829 721 1103068
SGTC_3066 9117245 49.47 µM -0.375110689214634 0.373999243985953 no 2114 0.353789073833301 716 17176980
SGTC_3164 9100705 49.47 µM -0.376278119457269 0.373567705694473 no 2115 0.353355072106149 718 17174235
SGTC_2684 capsaicin 100 µM -0.376522203488507 0.373477500526685 no 2116 0.353264355948945 729 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3295 9122362 53.5725 µM -0.379333389143855 0.372439082632697 no 2117 0.352220154102073 734 4730473
SGTC_3274 9138298 49.47 µM -0.380041521473127 0.372177652952473 no 2118 0.351957296841591 712 17015756
SGTC_2029 5175081 200 µM -0.380761093055622 0.37191206044411 no 2119 0.351690265808177 700 1380876
SGTC_1966 st070145 16.1 µM -0.380969725962089 0.371835065823778 no 2120 0.351612856385406 703 3748532
SGTC_1610 st001799 48.1 µM -0.38251442753444 0.371265163383512 no 2121 0.351039914729772 688 621897
SGTC_2189 6047310 154.431 µM -0.3831241618777 0.371040285496681 no 2122 0.350813852682548 699 711535
SGTC_69 0096-0274 206.684 µM -0.38336598740603 0.370951109314235 no 2123 0.350724209282349 730 6741392
SGTC_3254 9136651 49.47 µM -0.383497243035125 0.370902710063729 no 2124 0.350675557017898 735 16454030
SGTC_845 0330-0138 4.51 µM -0.384851466499931 0.370403472556262 no 2125 0.350173732790094 737 9039800
SGTC_3088 9117578 49.47 µM -0.387833136321588 0.369305043444477 no 2126 0.349069760938101 711 678341
SGTC_1102 cgs 12066b 26.1 µM -0.388550550567782 0.369040911162326 no 2127 0.348804326355285 690 6438352 A 5-HT1B full agonist.
SGTC_265 mycophenolic acid 32.932 µM -0.388745817200602 0.368969030033896 no 2128 0.348732092869355 731 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1344 1488-0097 29.1 µM -0.389000326147918 0.368875347632702 no 2129 0.348637952559877 719 747966
SGTC_2687 chenodiol 100 µM -0.389738773008289 0.368603576249634 no 2130 0.348364861233618 694 5702181 A cholesterol synthesis inhibitor.
SGTC_2734 clemastine 41.6 µM -0.391256300976969 0.368045285212592 no 2131 0.347803898106781 720 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_12 0849-0099 9.267 µM -0.392920952967693 0.367433188406723 no 2132 0.347188932717044 736 6071388
SGTC_3275 9138069 49.47 µM -0.393863653065751 0.367086704370027 no 2133 0.346840853222641 730 17617007
SGTC_3175 9106517 49.47 µM -0.394554352529267 0.366832910404609 no 2134 0.346585903622165 726 41468073
SGTC_677 0929-0063 136 µM -0.395532350431651 0.366473649670677 no 2135 0.346225025844992 722 1539583
SGTC_3318 9139014 38.6185 µM -0.395783597680865 0.366381374612212 no 2136 0.346132339017959 740 16643984
SGTC_3350 9150499 3.57 µM -0.39594835137766 0.36632087005526 no 2137 0.346071565256377 717 4910996 YPR165W RHO1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.39755241359816 0.365731964138994 no 2138 0.345480071858337 723 688803
SGTC_686 1319-0111 510 µM -0.397955705860668 0.365583951505537 no 2139 0.345331418248793 767 4562600
SGTC_2537 larixol 68.93 µM -0.39799834303104 0.365568304370992 no 2140 0.34531570357319 716 6708759
SGTC_1999 st074831 12.5 µM -0.398299765347456 0.36545769376089 no 2141 0.345204616709071 762 17112523
SGTC_2881 9058953 51.95 µM -0.399264974223349 0.365103573861777 no 2142 0.344848986207629 688 17122249
SGTC_3171 9103192 49.47 µM -0.399990683004734 0.364837398489643 no 2143 0.344581689567223 724 13018434
SGTC_1104 tacrolimus 29.8 µM -0.400064479518262 0.36481033506022 no 2144 0.344554512814677 713 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3141 9094609 49.47 µM -0.400903979006658 0.364502512472195 no 2145 0.344245410140592 724 25236309 YDL196W YDL196W
SGTC_1441 4106-0040 13 µM -0.403371404976768 0.363598278012697 no 2146 0.343337509758383 710 2904180
SGTC_2979 9012552 45.46 µM -0.40366718455284 0.363489934916247 no 2147 0.343228736876647 731 17100905
SGTC_1461 k072-0203 53.8 µM -0.403838329380801 0.363427250108252 no 2148 0.343165804329879 723 5418714
SGTC_2723 salbutamol 83.58 µM -0.404094187442559 0.363333544406419 no 2149 0.343071729555326 738 9884233 β2-adrenoceptor agonist
SGTC_2464 5717415 7.67 µM -0.404340491704974 0.36324334542273 no 2150 0.342981176742591 717 5285744
SGTC_2367 9070478 135.38 µM -0.4049013709693 0.363037974358458 no 2151 0.342775005298805 698 572802
SGTC_2654 protoveratrine a 100 µM -0.405196482644568 0.362929932330201 no 2152 0.342666545130612 729 5702278 A heart drug and vasodilator.
SGTC_2923 7992654 58.14 µM -0.405721433079774 0.362737772018541 no 2153 0.342473646113814 689 2985126
SGTC_341 1486-1430 230 µM -0.407163572283015 0.362210048937188 no 2154 0.341943927213814 738 2054753 YPL210C SRP72
SGTC_1723 st034307 2.5525 µM -0.408620510152264 0.361677176377573 no 2155 0.341409088304871 697 867466
SGTC_1625 st003711 30.1 µM -0.408736642914546 0.361634712540985 no 2156 0.341366469890762 719 24207034 YER133W GLC7
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.413530923371977 0.359883181084537 no 2157 0.339608835492232 733 94937 An inhibitor of serotonin biosynthesis.
SGTC_1486 3970-0793 4.53 µM -0.413845551302009 0.359768337983113 no 2158 0.339493610894124 743 2844330
SGTC_2251 lansoprazole 556 µM -0.417731393575142 0.358351003990793 no 2159 0.338071758277124 747 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_635 k038-0028 24.7 µM -0.41799485395725 0.358254978992366 no 2160 0.337975439847908 746 4035102
SGTC_1120 ficusin 1.78878 µM -0.418462863431957 0.358084422858414 no 2161 0.337804366515176 744 6199 A DNA cross-linker.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.419443034166843 0.357727312203273 no 2162 0.337446189463143 696 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2314 7727897 200 µM -0.419713500042674 0.357628793880609 no 2163 0.33734738088332 698 900724
SGTC_2416 tofa 880 nM -0.420649770195181 0.357287826861077 no 2164 0.337005422448938 726 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1082 camptothecin 424.86 nM -0.422963940751436 0.356445550973786 no 2165 0.336160785082604 732 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2817 7995342 71.43 µM -0.423131661436784 0.35638453374686 no 2166 0.336099601631058 760 18879975
SGTC_1889 st059080 5.18 µM -0.423483967116858 0.356256375986146 no 2167 0.335971096874741 733 176925 Isolated from Daphnopsis sellowiana.
SGTC_3089 9117425 49.47 µM -0.423921293145354 0.356097313073064 no 2168 0.335811607312685 760 9401657
SGTC_3068 9116768 49.47 µM -0.424047951855832 0.356051249821401 no 2169 0.335765421339732 754 41904888
SGTC_2287 7945887 168.79 µM -0.427313575876333 0.354864334501889 no 2170 0.334575472974921 713 1245853
SGTC_269 exalamide 29 µM -0.427515745268694 0.35479090067656 no 2171 0.334501859673046 708 3316 A derivative of salicylamide.
SGTC_570 0987-0065 62.6 µM -0.42850766253331 0.354430685586496 no 2172 0.334140778017583 698 3104428
SGTC_854 0422-0053 192 µM -0.42964188211204 0.354018952892921 no 2173 0.333728082968401 715 3596728
SGTC_2902 5787006 60.46 µM -0.429856316898236 0.353941130153521 no 2174 0.33365008170796 736 591003
SGTC_3078 9116413 49.47 µM -0.430449899474707 0.353725738810709 no 2175 0.333434201870311 715 17177322
SGTC_1134 3477-0009 42.5 µM -0.431463626552965 0.353357999306248 no 2176 0.333065647383987 750 3973534
SGTC_362 0310-0100 9.03 µM -0.432888667865207 0.352841282981731 no 2177 0.332547826514731 722 790235
SGTC_1239 0337-0584 35.4 µM -0.433099150116428 0.352764985631365 no 2178 0.332471370092459 742 914301 YML130C ERO1
SGTC_1797 st048695 56.8 µM -0.433193297892713 0.352730860081832 no 2179 0.332437173730027 771 592262 YIL048W NEO1
SGTC_2486 5283202 22.39 µM -0.433943471164725 0.352458988686362 no 2180 0.332164745586754 732 1377751
SGTC_2726 cimetidine 79.27 µM -0.434897803618397 0.352113236588389 no 2181 0.33181830446355 745 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_811 0416-0114 265 µM -0.434967492545988 0.352087993261022 no 2182 0.331793011665087 753 6612453
SGTC_2814 7977482 42.97 µM -0.435856822417169 0.35176590975322 no 2183 0.331470306923629 742 6456762
SGTC_1574 spiramycin 23.7 µM -0.436583002684569 0.351502992070863 no 2184 0.3312068958501 721 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1718 roemerine 11.9335 µM -0.436785202811568 0.351429797005193 no 2185 0.33113356562313 734 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3267 9137951 49.47 µM -0.437083259978842 0.351321912391507 no 2186 0.331025483535711 731 16643986
SGTC_2872 9044037 25.97 µM -0.438140771289169 0.350939232856119 no 2187 0.33064212031481 742 6465195
SGTC_2302 7771753 200 µM -0.439736478758034 0.350362083529091 no 2188 0.330063989426212 709 2203047
SGTC_788 1182-0090 188 µM -0.441104181469236 0.349867675717253 no 2189 0.329568788234163 714 5715185
SGTC_2275 7947463 200 µM -0.441654765153999 0.349668718229769 no 2190 0.329369523851828 748 1225414
SGTC_992 3909-8734 162 µM -0.442397114368502 0.349400530208737 no 2191 0.329100933394892 760 4288319
SGTC_1005 4092-0690 4.4 µM -0.442531214025093 0.349352092124078 no 2192 0.329052424002957 755 1529343
SGTC_2095 5432005 200 µM -0.44431901294362 0.348706556635388 no 2193 0.328405978478829 775 783734
SGTC_2106 5357045 167.29 µM -0.444391469833278 0.348680403239555 no 2194 0.328379789794125 733 668842
SGTC_899 1083-0020 478 µM -0.444435100614467 0.348664655006879 no 2195 0.328364020371713 766 767123
SGTC_1453 4237-0541 195 µM -0.445674613129212 0.348217370453511 no 2196 0.327916152638403 749 739892
SGTC_2841 9004761 38.96 µM -0.447126441700284 0.347693738917724 no 2197 0.327391884218206 714 2991039
SGTC_2393 9031399 185.94 µM -0.447331232204493 0.347619900401892 no 2198 0.32731795987545 759 1526623 YDL150W RPC53
SGTC_1265 0819-1001 68.8 µM -0.447433143010069 0.3475831579681 no 2199 0.327281175100656 733 3106768
SGTC_368 fentichlor 4.58 µM -0.448014560801224 0.34737356377696 no 2200 0.327071344042925 775 7329 A pesticide.
SGTC_1295 1013-0063 9.78 µM -0.448531444611566 0.34718727249459 no 2201 0.326884848894216 741 6826038
SGTC_932 2857-0803 154 µM -0.450122476375011 0.346614076961029 no 2202 0.326311065469368 748 674898
SGTC_1493 4348-0038 111 µM -0.451652161519113 0.346063313460268 no 2203 0.325759793154203 756 800424
SGTC_2229 7354935 190 µM -0.452523376973173 0.345749777520665 no 2204 0.325445992138724 755 318112
SGTC_1168 k815-0004 80.5 µM -0.452552334823919 0.345739357887166 no 2205 0.325435564002478 724 642433
SGTC_584 0986-0246 15.4 µM -0.452788835095551 0.345654264573625 no 2206 0.325350401988237 757 53315 YDR232W HEM1
SGTC_997 3996-0078 137 µM -0.454156366376667 0.345162376857647 no 2207 0.324858142932587 739 735687
SGTC_1713 st033146 12.748 µM -0.454990093299612 0.34486262162396 no 2208 0.324558182986891 771 674619
SGTC_2957 9076800 11.52 µM -0.455535509685359 0.344666577203452 no 2209 0.324362013530081 756 16459615
SGTC_2271 7849410 118.62 µM -0.456304711781008 0.344390166162976 no 2210 0.324085438093141 772 972430
SGTC_1810 st050138 53 µM -0.456911390411739 0.344172216163484 no 2211 0.323867368289726 777 3444541
SGTC_2227 7312221 64.1025 µM -0.459093085968322 0.343388867621451 no 2212 0.323083660748427 747 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_976 1348-1067 47.6 µM -0.462920479382524 0.342016248943762 no 2213 0.321710683768891 732 5310671 YGL099W LSG1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.464433420170553 0.341474236793724 no 2214 0.321168625332093 723 6708784 An antioxidant flavonoid
SGTC_2775 cyproheptadine 69.59 µM -0.466075497143923 0.340886331306144 no 2215 0.320580730726384 753 2913 A selective serotonin reuptake inhibitor.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.468546451155384 0.34000239480343 no 2216 0.319696930464353 743 66535 A nucleotide analog.
SGTC_2656 pseudo-anisatin 100 µM -0.468663527384427 0.339960534791893 no 2217 0.319655080480911 765 6708809 A neurotoxin.
SGTC_3153 9100258 49.47 µM -0.470788386149478 0.339201145631809 no 2218 0.318895929484705 772 25236848
SGTC_3001 9076041 71.4286 µM -0.472112902501512 0.33872811554827 no 2219 0.318423101710063 738 16004211
SGTC_1122 capsaicin 818.572 nM -0.472808586352457 0.338479764846947 no 2220 0.318174873830465 766 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.47307313979535 0.33838534090131 no 2221 0.318080499584481 750 4620898
SGTC_2824 7998404 51.95 µM -0.473450830894327 0.33825055367418 no 2222 0.317945786169251 772 837851
SGTC_2943 9068529 45.32 µM -0.473577396923214 0.338205390488456 no 2223 0.317900648470144 751 3270634
SGTC_1249 0481-0015 10.2 µM -0.473797502699541 0.338126854594183 no 2224 0.317822157797534 772 4227577
SGTC_2882 9058044 58.44 µM -0.474353649044663 0.337928447527074 no 2225 0.31762387007872 748 18076804
SGTC_3122 9126309 49.47 µM -0.474480094442081 0.337883343988274 no 2226 0.317578794691655 770 17591206
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.474883205449461 0.337739568349 no 2227 0.317435111315254 739 5377381
SGTC_1886 st057356 49.9 µM -0.475560584354858 0.337498024240302 no 2228 0.31719373086352 722 24207747
SGTC_1109 tnp00067 928.257 nM -0.476003037560844 0.337340287577165 no 2229 0.317036106933781 759 676295
SGTC_2781 5567276 71.43 µM -0.4767160937029 0.337086139846636 no 2230 0.316782150586676 763 2853274
SGTC_1892 st058411 7.36 µM -0.476992373114083 0.336987688213838 no 2231 0.316683776325408 773 3934738
SGTC_3287 9117173 37.0625 µM -0.478438981735795 0.336472374463709 no 2232 0.31616889703808 737 2789709
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.478614649477806 0.336409818641959 no 2233 0.316106397329717 769 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1734 st037168 69.4 µM -0.479238513121039 0.336187695491048 no 2234 0.315884479329956 749 708907
SGTC_2004 4023728 41.89 µM -0.480688547814642 0.335671639780735 no 2235 0.315368935839318 754 360084 YDR527W RBA50
SGTC_558 k064-0027 21.3 µM -0.48108275704825 0.33553139739188 no 2236 0.31522884125811 734 5088526
SGTC_3094 9117742 49.47 µM -0.481138048792271 0.335511728841342 no 2237 0.315209193731467 785 17149698
SGTC_2389 9091542 195.52 µM -0.482656457136445 0.334971772232743 no 2238 0.314669842585766 736 3626624 YOL127W RPL25
SGTC_531 3788-1495 174 µM -0.483680328923586 0.334607868651956 no 2239 0.31430637788782 713 2896655
SGTC_2136 5328288 199.296 µM -0.483983649320605 0.334500092596746 no 2240 0.314198736584948 736 262395
SGTC_2293 7624732 200 µM -0.484172651923977 0.334432942930568 no 2241 0.314131671978702 753 894453
SGTC_1379 2144-0755 36.5 µM -0.484435418130066 0.334339595012482 no 2242 0.31403844371335 767 5392327
SGTC_2712 st079126 47.7 µM -0.484786202114399 0.334214994668948 no 2243 0.313914005632578 745 3152970
SGTC_147 4466-0538 29.23 µM -0.485160133223107 0.334082192457667 no 2244 0.313781379577163 762 6742687 YHR072W ERG7
SGTC_2838 9002687 71.43 µM -0.48672986211214 0.333524927598839 no 2245 0.313224890067889 763 6457060
SGTC_253 dyclonine 31.25 µM -0.487929025874385 0.333099463262937 no 2246 0.312800057065702 747 3180 An oral anasthetic.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.488835166302612 0.332778106255037 no 2247 0.312479199534387 747 442882
SGTC_535 2293-4129 48.2 µM -0.488936803413853 0.332742068948175 no 2248 0.31244321945446 787 396118 YIL048W NEO1
SGTC_2067 5224629 34.075 µM -0.489351088002498 0.332595192718328 no 2249 0.312296578998723 758 2835000
SGTC_460 trequinsin 123 µM -0.489397975887735 0.332578571184223 no 2250 0.312279984403024 753 5537 A vasodilator.
SGTC_1635 st007035 42.4 µM -0.490236512442313 0.332281369537892 no 2251 0.311983273239059 760 3716403
SGTC_1651 st011928 86.1 µM -0.492376921552534 0.331523224963882 no 2252 0.311226455513152 751 720198
SGTC_2832 7992762 51.95 µM -0.492491233973257 0.331482754256805 no 2253 0.311186058694382 718 2985177
SGTC_108 0509-0257 621.132 µM -0.493536090559513 0.331112928686767 no 2254 0.310816922704018 740 536624
SGTC_2434 5670830 169.91 µM -0.496630399563924 0.330018669428228 no 2255 0.309724855873924 776 1549830
SGTC_1388 3346-4487 254 µM -0.496812858262538 0.329954190719078 no 2256 0.309660513455076 769 3345614
SGTC_2328 6201408 200 µM -0.497378845347868 0.329754209838401 no 2257 0.309460960313573 792 2890418
SGTC_46 0329-0187a 2.197 µM -0.500575391085093 0.328625685428387 no 2258 0.308334992623976 776 46494817
SGTC_502 l-744,832 89.3 µM -0.500832699812491 0.328534911635865 no 2259 0.30824443504936 774 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3110 9122132 49.47 µM -0.501789911111009 0.328197313943963 no 2260 0.307907655323088 730 918317
SGTC_809 3998-0021 90 µM -0.502000767914601 0.328122965957422 no 2261 0.307833490404236 782 715485
SGTC_456 gingerol 170 µM -0.503641374843955 0.327544721687036 no 2262 0.307256706085283 789 442793 A herb.
SGTC_3192 9110362 49.47 µM -0.503678292626354 0.327531714487821 no 2263 0.30724373246359 766 16649480
SGTC_1488 4013-0813 75.9 µM -0.506270756403716 0.326618839015996 no 2264 0.306333294656161 745 2910057
SGTC_1964 st076914 61 µM -0.506381454341247 0.326579882377863 no 2265 0.306294445606595 786 24208661
SGTC_90 0870-0863 4.608 µM -0.506385973715353 0.326578291967252 no 2266 0.306292859594505 790 1738164
SGTC_2593 nobiletin 86.24 µM -0.507425940234135 0.326212401748876 no 2267 0.305927994235227 741 72344 An anti-infammatory.
SGTC_283 0987-0079 11.7 µM -0.508911666767174 0.325689970434544 no 2268 0.305407070936501 752 411556
SGTC_316 k060-0003 58.6 µM -0.509141235960711 0.325609276695506 no 2269 0.305326614813332 773 6152314
SGTC_1814 st052110 31.539 µM -0.509211484164089 0.325584586033453 no 2270 0.305301997107902 782 674163
SGTC_1575 cyproterone acetate 48 µM -0.509534491329522 0.325471066136772 no 2271 0.305188814156296 785 9880 An androgen receptor antagonist and liver toxin.
SGTC_403 arphamenine a 50 µM -0.50989854012171 0.325343141688521 no 2272 0.305061272388357 774 5487158 An arginine aminopeptidase inhibitor.
SGTC_1731 st035964 63 µM -0.51172330172086 0.324702242285146 no 2273 0.30442233779414 782 6739575
SGTC_2623 humulene 100 µM -0.512911307634383 0.324285265138784 no 2274 0.3040066816297 772 6187145 An anti-inflammatory.
SGTC_2815 7968870 71.43 µM -0.513351140330564 0.324130944491289 no 2275 0.303852858404773 778 2977326 YHR190W ERG9
SGTC_1150 3909-7983 10.9 µM -0.51371085083154 0.324004758146539 no 2276 0.303727082226417 763 23965914
SGTC_2630 antimycin a 100 µM -0.51415985370446 0.323847276434975 no 2277 0.303570116736198 783 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_249 wiskostatin 11.211 µM -0.516422259379356 0.323054248254871 no 2278 0.302779761225538 763 2775510 A n-wasp and actin depolymerizer.
SGTC_138 0850-0259 40.9225 µM -0.518129822679764 0.322456237734544 no 2279 0.302183846970553 759 6813004
SGTC_22 0964-0034 14.468 µM -0.518595797301022 0.322293127127662 no 2280 0.302021320216164 795 138402
SGTC_695 3505-6186 243 µM -0.520167064160537 0.321743370330179 no 2281 0.301473569466976 787 1819379
SGTC_2356 9061756 188.97 µM -0.52064573094339 0.321575971255922 no 2282 0.301306792940044 737 20104043
SGTC_1747 st037496 66.6 µM -0.520714851677982 0.321551801384286 no 2283 0.301282713406817 780 723305
SGTC_2363 9053361 176 µM -0.523509311061653 0.320575279166015 no 2284 0.300309936607458 786 6469797 YMR079W SEC14
SGTC_1555 citronellol 128 µM -0.52505478014588 0.32003574819995 no 2285 0.29977255508058 778 8842 A terpine precursor.
SGTC_1785 bathophenanthroline 24 µM -0.525862283335985 0.319753996027048 no 2286 0.299491948079284 763 72812 An iron chelator.
SGTC_42 0133-0086 60.653 µM -0.52598469538648 0.319711293365197 no 2287 0.29944942034115 788 162923 Model of phenazepam hydroxylation.
SGTC_2504 purpurogallin 52.29 µM -0.52726493623511 0.319264832804799 no 2288 0.299004810084197 737 5281571 An antioxidant.
SGTC_1707 st032323 6.317 µM -0.527518274086622 0.319176516893833 no 2289 0.29891686483157 773 3132057 YMR211W DML1
SGTC_446 go6976 132 µM -0.529114089812623 0.318620436879204 no 2290 0.298363153932507 779 3501 A protein kinase C inhibitor.
SGTC_408 cantharidin 100 µM -0.530771827217113 0.318043211833178 no 2291 0.297788452558076 752 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_183 3914-0051 30.55 µM -0.530877131163637 0.318006559849518 no 2292 0.29775196303976 774 1596232
SGTC_1381 2324-0066 62.1 µM -0.531806985632618 0.317682993051879 no 2293 0.297429842011733 792 10885928
SGTC_268 camptothecin 39.6153 µM -0.532399063383885 0.317477036875482 no 2294 0.297224816871923 790 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2283 7944793 200 µM -0.532802454734764 0.317336748228295 no 2295 0.297085167211272 761 2970533
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.533508631080611 0.317091222293898 no 2296 0.296840768971895 769 16725076
SGTC_1316 1272-0050 65.9 µM -0.535210051426285 0.316499997128482 no 2297 0.296252308294273 802 7340392
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.535278872052268 0.316476092556175 no 2298 0.296228516954342 769 5379071
SGTC_1301 naphtanilide LB 4.81 µM -0.53653299653586 0.31604061174278 no 2299 0.295795118804414 780 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1163 k060-0048 49.9 µM -0.53696637099066 0.315890186552503 no 2300 0.295645421767807 753 6809982
SGTC_1588 farnesol 29.9 µM -0.538537039124385 0.315345259908546 no 2301 0.295103170592981 762 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2059 5238311 157 µM -0.538652197527343 0.315305322703653 no 2302 0.295063431795278 764 703021
SGTC_977 1348-1378 135 µM -0.539253284286989 0.315096899440764 no 2303 0.294856049130128 780 X977
SGTC_1403 3909-7815 62.9 µM -0.53965050495676 0.31495919782537 no 2304 0.294719039768254 761 6615483
SGTC_647 0140-0236 81 µM -0.540110416559095 0.314799795723458 no 2305 0.294560443733588 769 990837
SGTC_2784 7567673 72.73 µM -0.540343745418664 0.314718938783758 no 2306 0.294479997609966 776 3471247
SGTC_3133 9127736 49.47 µM -0.541318851772023 0.314381125118498 no 2307 0.294143914413645 757 27243420
SGTC_244 nsc-207895 1.295 µM -0.541564966225786 0.314295886324664 no 2308 0.294059115860428 749 42640
SGTC_1916 st067606 49.2 µM -0.542049933941038 0.314127952546385 no 2309 0.293892053672547 758 19590279
SGTC_2036 5160441 105 µM -0.542586797862445 0.313942093112664 no 2310 0.293707165436967 784 134534 YIL048W NEO1
SGTC_1160 4092-0570 10.5 µM -0.543429750447246 0.31365036264312 no 2311 0.293416973323567 786 4994975
SGTC_1472 k841-0093 193 µM -0.54455227391102 0.313262058680008 no 2312 0.293030743402835 790 X1472
SGTC_902 1120-0002 2.07 µM -0.544913201106565 0.31313725048281 no 2313 0.292906608258111 778 3280475
SGTC_2778 tioconazole 65.09 nM -0.547341726471873 0.312298026413121 no 2314 0.292071991040623 798 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.547831135899489 0.312129019130078 no 2315 0.291903928626265 779 5106787 A p450 inhibitor.
SGTC_813 k007-0158 173 µM -0.549878891942634 0.311422298596265 no 2316 0.291201221435596 783 6523916
SGTC_2558 carylophyllene oxide 100 µM -0.55070549584795 0.311137218025803 no 2317 0.290917788276713 803 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1203 3992-3522 103 µM -0.551292461079899 0.310934853209463 no 2318 0.290716602829094 808 5322312
SGTC_1443 4112-3303 14 µM -0.551466401131076 0.31087489581898 no 2319 0.290656996453955 794 704433
SGTC_2586 curcumin 80 µM -0.552083509681553 0.310662218111212 no 2320 0.290445569705354 772 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2698 st077697 67.5 µM -0.552250651376296 0.310604625981042 no 2321 0.290388317901645 783 3154499
SGTC_3120 9124077 49.47 µM -0.552697194202431 0.310450783176121 no 2322 0.290235387480492 788 18774327 YGL155W CDC43
SGTC_641 4092-0595 30 µM -0.553798109521271 0.31007163781191 no 2323 0.289858511122632 776 786260
SGTC_1425 4048-4433 7.33 µM -0.556759309213077 0.309052829657203 no 2324 0.288845944336882 814 23734946
SGTC_1311 1190-0148 100 µM -0.559133941448422 0.308236890815694 no 2325 0.288035156070492 795 1961333
SGTC_3046 9092212 49.47 µM -0.559185589804128 0.308219154614293 no 2326 0.288017533332409 781 25236637
SGTC_1730 st033808 45.1 µM -0.560020453001989 0.307932522208159 no 2327 0.287732743478781 795 1045166
SGTC_1965 Pectolinarigenin 58.4 µM -0.560221653947541 0.30786346168168 no 2328 0.287664129395717 784 5320438 An anti-inflammatory.
SGTC_2785 7756463 72.73 µM -0.560801002088325 0.307664643338259 no 2329 0.287466601748771 810 2201551
SGTC_2289 7946404 165.07 µM -0.560863447487104 0.307643216950342 no 2330 0.287445314938818 762 1246120 YPR165W RHO1
SGTC_2117 5521686 200 µM -0.561035846634753 0.307584066422474 no 2331 0.287386550221636 772 803312
SGTC_2719 novobiocin 32.65 µM -0.561408197158466 0.307456329207259 no 2332 0.287259648611538 793 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_555 4296-0685 37 µM -0.562774902730429 0.306987672383636 no 2333 0.286794086094187 800 2908540 YHR072W ERG7
SGTC_1908 st060353 56.5 µM -0.563137015253793 0.306863553215605 no 2334 0.28667079394216 820 4227716
SGTC_2823 7987624 58.44 µM -0.563819503910246 0.306629680801356 no 2335 0.28643848840276 824 2239440
SGTC_849 0386-0493 241 µM -0.564928335688617 0.306249878730739 no 2336 0.286061254751767 795 726119
SGTC_2677 mitomycin C 100 µM -0.565520609425369 0.306047095695315 no 2337 0.285859855145393 796 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1874 staurosporine 7.6 µM -0.565840243234488 0.305937683965066 no 2338 0.28575119334766 799 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_733 4069-0007 56.1 µM -0.566435980367828 0.305733807350607 no 2339 0.285548720702 788 5717425 YNL287W SEC21
SGTC_1372 2752-0194 270 µM -0.566465393517588 0.305723742971027 no 2340 0.285538725850389 783 823334
SGTC_727 3032-0951 202 µM -0.566761920937334 0.305622287553964 no 2341 0.285437972481512 778 3652836
SGTC_1255 0566-0045 221 µM -0.567014437176132 0.305535902112 no 2342 0.285352186473198 780 2788469
SGTC_2388 9080168 200 µM -0.567268236661722 0.305449088580198 no 2343 0.285265976890007 798 15943073
SGTC_1942 st076330 65.2 µM -0.56790581339694 0.305231050160392 no 2344 0.285049462160764 810 24208414
SGTC_1469 k284-2957 126 µM -0.567957330101316 0.305213435499787 no 2345 0.285031971021175 776 23884841
SGTC_605 1315-0399 119 µM -0.568703135772307 0.304958479181878 no 2346 0.284778809705757 782 24020461
SGTC_3028 9087778 49.47 µM -0.568864591972388 0.30490329726591 no 2347 0.284724018055043 767 17217395
SGTC_1936 st074407 74.3 µM -0.569393903069907 0.304722422354791 no 2348 0.284544426747851 774 809813
SGTC_1623 st003709 20.3 µM -0.56999159999385 0.304518236173566 no 2349 0.28434169769946 770 16192618
SGTC_3220 9131269 49.47 µM -0.572886117697084 0.303530268917356 no 2350 0.283360902346992 797 17722206
SGTC_2716 st080858 38.6235 µM -0.573123638557898 0.303449261026219 no 2351 0.283280491456197 772 5296050
SGTC_1685 st024049 53.0905 µM -0.57347167553778 0.30333057840869 no 2352 0.283162685939663 787 1941139
SGTC_1761 st044296 37 µM -0.573667705640734 0.303263740147477 no 2353 0.283096342916404 784 1826700
SGTC_2330 7979373 200 µM -0.574853352249415 0.302859623481523 no 2354 0.282695240251769 776 1863007
SGTC_643 k048-0106 28.4 µM -0.575007914116668 0.302806960268735 no 2355 0.282642972305501 792 6763920
SGTC_691 1548-0686 185 µM -0.575307195540912 0.302704999031615 no 2356 0.282541777977609 802 46495133
SGTC_1808 st050063 61.5 µM -0.575536630458751 0.302626843995149 no 2357 0.282464212249369 819 4011993
SGTC_1460 k062-0059 9.15 µM -0.577559514746259 0.301938157510947 no 2358 0.281780773424077 757 1373085
SGTC_1458 k015-0034 6.33 µM -0.577648489910643 0.301907882284302 no 2359 0.281750731149156 801 3598957
SGTC_109 0132-0036 33.701 µM -0.578416789821416 0.301646512677294 no 2360 0.281491380565882 741 67274 A color developer.
SGTC_492 tmb-8 126 µM -0.578433760987858 0.301640740368432 no 2361 0.281485653007207 775 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1776 st049249 45.9 µM -0.57973332049757 0.301198876028039 no 2362 0.281047234831574 790 1822314
SGTC_323 4013-0906 34.3 µM -0.581048250505518 0.300752082570562 no 2363 0.280603967340842 770 2910086
SGTC_1848 st056003 16.4 µM -0.581722097416661 0.300523235471294 no 2364 0.280376942363373 785 146492
SGTC_1665 st014639 11.4 µM -0.583572373620771 0.299895262619787 no 2365 0.279754025740297 799 981133 YIL048W NEO1
SGTC_2236 dapsone 200 µM -0.583902711337311 0.299783210459728 no 2366 0.279642884456477 784 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2764 methyldopa 94.69 µM -0.584000012692581 0.2997502089817 no 2367 0.279610151749617 806 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_982 1491-0518 27.5 µM -0.586108237787349 0.299035571512127 no 2368 0.278901390402169 794 3091256
SGTC_2842 9000675 19.48 µM -0.58712331026163 0.298691762561143 no 2369 0.278560446587402 788 2989072
SGTC_3051 9093778 49.47 µM -0.590508799060881 0.297546385867593 no 2370 0.277424794196917 816 17217378
SGTC_86 0417-1630 471.922 µM -0.591971526829399 0.297052137696881 no 2371 0.276934827585015 796 3634867
SGTC_2181 6316240 54.2555 µM -0.593422392170658 0.296562269020275 no 2372 0.276449253431972 784 12779990
SGTC_946 3434-1334 87.4 µM -0.593571037352522 0.296512101522748 no 2373 0.276399528600911 781 4047976
SGTC_2040 5100729 123 µM -0.599061941068556 0.294661662320307 no 2374 0.274565790002389 797 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2971 9092186 9.93 µM -0.599576949280111 0.294488377681609 no 2375 0.274394106546873 762 25236400
SGTC_1181 1222-0449 220 µM -0.601699986918035 0.293774536994998 no 2376 0.273686929360114 805 658318
SGTC_428 3448-4153 16.5 µM -0.602207317726107 0.293604072946145 no 2377 0.2735180726253 762 3834874
SGTC_2795 7780010 54.55 µM -0.602317372222604 0.293567100486065 no 2378 0.273481449599377 795 953673
SGTC_160 3453-0671 289.699 µM -0.603578492367193 0.293143585138076 no 2379 0.273061957820304 822 5322268
SGTC_734 2023-0417 80 µM -0.604858904357482 0.292713881203089 no 2380 0.272636375465225 812 3935732
SGTC_2086 5274770 176.623 µM -0.605549347972776 0.292482291049983 no 2381 0.272407023050679 787 689278
SGTC_3145 9085516 49.47 µM -0.605695987773264 0.292433115764651 no 2382 0.272358324401054 812 25236195
SGTC_1511 0906-3109 28.5 µM -0.606261491887525 0.292243511395316 no 2383 0.272170562643381 788 2882180
SGTC_1210 3013-0140 750 nM -0.608047210332857 0.291645164658467 no 2384 0.271578081359876 796 905973
SGTC_2120 5538279 151.968 µM -0.60865462809418 0.291441765373707 no 2385 0.271376693473698 787 2058197
SGTC_2690 usnic acid 100 µM -0.610897277817378 0.290691367795593 no 2386 0.270633793555048 821 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_592 k241-0073 46.5 µM -0.611461344943041 0.29050277150414 no 2387 0.27044710072528 810 4230158
SGTC_1097 itavastatin 7.23 µM -0.611732592455156 0.290412100077652 no 2388 0.270357347158155 795 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_36 0335-0881 14.2 µM -0.612409907771782 0.290185747956036 no 2389 0.270133294127588 793 23828853
SGTC_286 k060-0067 22.9 µM -0.612566677263909 0.290133368915107 no 2390 0.270081448684965 786 5985051
SGTC_78 0336-0123 156.75 µM -0.615102361495055 0.289286774779852 no 2391 0.269243561317974 804 6765896
SGTC_1024 4507-0395 26 µM -0.615851782812079 0.289036786392168 no 2392 0.268996173610842 774 4201836
SGTC_1710 st031758 61.5 µM -0.616795629206383 0.288722087271957 no 2393 0.268684767643087 806 5394341
SGTC_516 3992-2719 87.3 µM -0.618933155416627 0.288009986169922 no 2394 0.267980197699002 775 5350887 YDR037W KRS1
SGTC_563 tetrahydrosecaminediol 614 µM -0.620031856332402 0.287644284929736 no 2395 0.267618406978868 816 334274 A psychoactive constituent of the cannabis plant.
SGTC_501 nsc-95397 161 µM -0.620740345441541 0.287408581654757 no 2396 0.267385239571033 809 262093
SGTC_2601 securinine 100 µM -0.621472548674843 0.287165085097395 no 2397 0.267144375450244 827 442872 A GABA receptor antagonist.
SGTC_1855 st056195 39.6 µM -0.621619625776047 0.287116185911872 no 2398 0.267096006472901 800 4028379
SGTC_1695 st026914 34.495 µM -0.621629123703617 0.287113028241602 no 2399 0.267092883058822 801 3289191
SGTC_79 0052-0007 94.094 µM -0.623416615728984 0.286519053606681 no 2400 0.266505390936672 803 2801472
SGTC_288 1315-0019 35.1 µM -0.623946254023587 0.286343169485262 no 2401 0.266331441179767 818 6811474
SGTC_1144 3486-0183 12.5 µM -0.624217079910488 0.286253252494959 no 2402 0.266242515707199 839 6744069
SGTC_402 epigallocatechin gallate 10 µM -0.624629430991058 0.286116373433346 no 2403 0.266107149414243 815 65064 An antioxidant.
SGTC_2490 carminic acid 95.39 µM -0.625162490446705 0.285939471578479 no 2404 0.265932208734123 794 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_710 3448-4187 58 µM -0.626019517170873 0.285655166535958 no 2405 0.265651069934097 787 3946412
SGTC_2088 5278280 127.392 µM -0.628222659448191 0.284924926931419 no 2406 0.264929044155599 813 791502
SGTC_2816 7982706 58.44 µM -0.628471808532271 0.28484240162547 no 2407 0.264847454475016 814 2981853
SGTC_1526 st051518 75 µM -0.629377968808157 0.284542351617331 no 2408 0.264550818894536 799 673993
SGTC_210 3551-0445 56.827 µM -0.630506947975394 0.284168732600162 no 2409 0.264181479202241 820 2865180 YOR207C RET1
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.631050703304936 0.283988868528419 no 2410 0.264003686215126 800 15053
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.631848828276277 0.283724962443857 no 2411 0.263742831856576 821 23847180
SGTC_632 0781-2353 4.65 µM -0.632954737411406 0.283359479419924 no 2412 0.263381600564607 818 6811515 YHR007C ERG11
SGTC_1682 st012968 530 nM -0.635224709359619 0.282610002620285 no 2413 0.26264093499337 788 24207270
SGTC_1428 4049-0204 61.7 µM -0.63608096326836 0.282327540914826 no 2414 0.26236182634158 819 X1428
SGTC_2177 5811945 192 µM -0.636506934698854 0.282187071739203 no 2415 0.262223031241284 802 5343475
SGTC_2268 7933382 153.85 µM -0.636972573997472 0.282033560105259 no 2416 0.262071354128843 793 935025 YOR257W CDC31
SGTC_819 1013-0258 27.7 µM -0.637606640800511 0.281824586102862 no 2417 0.261864885857391 817 5753198
SGTC_2566 crystal violet carbinol 226 nM -0.639029235570455 0.281356002912514 no 2418 0.261401956573609 831 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1933 st074711 15.9 µM -0.639171296342808 0.281309230702618 no 2419 0.261355751397366 822 17250958
SGTC_1431 4049-0260 9.09 µM -0.639356790132344 0.281248164219815 no 2420 0.26129542597522 823 3854841
SGTC_3130 9127414 49.47 µM -0.640017586422965 0.281030675243393 no 2421 0.261080583042567 821 1494646
SGTC_197 4544-0043 41.561 µM -0.640287990891099 0.280941700009736 no 2422 0.260992693349812 817 896523
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.640426023403173 0.280896286353553 no 2423 0.26094783444254 804 688667
SGTC_255 tunicamycin 200.472 nM -0.642434595041435 0.280235854142181 no 2424 0.260295521729762 803 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3134 9127454 49.47 µM -0.643353452079443 0.279933978579601 no 2425 0.259997389941544 821 24262820
SGTC_3003 9075612 71.4286 µM -0.644091810135248 0.279691517347264 no 2426 0.259757950407384 828 6501993
SGTC_453 enantio-paf c16 10 µM -0.644123350141048 0.279681162543815 no 2427 0.259747724944765 837 13871343 A lipid and platelet activating factor
SGTC_2049 5262831 67.185 µM -0.644275944688557 0.279631067319335 no 2428 0.259698255793874 812 763417
SGTC_214 4373-3496 70 µM -0.644401672727656 0.279589795366771 no 2429 0.259657500066838 825 3779166
SGTC_3050 9093513 49.47 µM -0.644698682664766 0.279492309528553 no 2430 0.259561235087034 826 25236664
SGTC_3020 9089140 49.47 µM -0.644739529514697 0.279478903896612 no 2431 0.259547997506309 812 17217859
SGTC_1836 st055642 81 µM -0.644959600977913 0.279406683454967 no 2432 0.259476683103416 821 8571
SGTC_2721 ifenprodil 61.44 µM -0.645099232133183 0.279360865660119 no 2433 0.259431440720034 821 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2541 muurolladie-3-one 83.07 µM -0.646936164585707 0.278758444912628 no 2434 0.258836629388395 820 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1280 0880-0253 10.1 µM -0.647060539661215 0.278717679058932 no 2435 0.258796381407634 819 6836607
SGTC_3161 9100388 49.47 µM -0.647071488118721 0.278714090671723 no 2436 0.258792838623726 823 25236368
SGTC_1583 clindamycin 39.6 µM -0.647081627439879 0.278710767501248 no 2437 0.258789557688604 815 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2134 5324836 1.464 µM -0.647405699065632 0.278604562933646 no 2438 0.258684704219522 834 699272
SGTC_1216 1165-0504 9.65 µM -0.649995980727819 0.277756386369038 no 2439 0.257847408921381 826 6304004
SGTC_2635 hydroquinidine 100 µM -0.651290808274518 0.277332873896205 no 2440 0.257429390371268 809 442912 An experimental heart treatment.
SGTC_2206 7254556 146.969 µM -0.651720041811376 0.277192549821157 no 2441 0.257290895547873 798 4398905
SGTC_336 4111-0029 111 µM -0.653371040745509 0.276653132889126 no 2442 0.25675855183466 830 3131175
SGTC_2912 7964298 10.93 µM -0.654453086176497 0.276299884604409 no 2443 0.25640997126546 813 2975850
SGTC_1338 1486-1223 76 µM -0.656060984294968 0.275775373722004 no 2444 0.255892443279523 807 3444526
SGTC_2922 7999257 32.47 µM -0.657034170609939 0.275458149448131 no 2445 0.255579472561808 830 2988377
SGTC_1345 1488-0192 31.4 µM -0.657959471923545 0.275156700560753 no 2446 0.255282086894228 821 658348
SGTC_3106 9121286 49.47 µM -0.658450719618632 0.27499672568335 no 2447 0.25512427670793 797 15943471
SGTC_1708 st033234 31.827 µM -0.658792971617632 0.274885298363301 no 2448 0.255014360602029 801 674664
SGTC_1784 st039334 36.3 µM -0.66008639510041 0.274464398256926 no 2449 0.254599194401149 846 3496984
SGTC_264 promethazine 12.5 mM -0.660162330817877 0.274439697481638 no 2450 0.25457483137798 844 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2939 9044578 71.43 µM -0.661168044469565 0.274112657104283 no 2451 0.254252275989848 826 2653634
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.66125354403782 0.274084863032058 no 2452 0.254224864207444 816 641818 YHR062C RPP1
SGTC_2417 cerulenin 830 nM -0.662184938774349 0.273782176853723 no 2453 0.253926352710252 824 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_768 0384-0033 77.3 µM -0.66393943345108 0.273212447701729 no 2454 0.253364538153893 820 3965305 YMR134W ERG29
SGTC_1478 0453-0656 35.7 µM -0.665264571094315 0.272782531431687 no 2455 0.252940643430742 836 5258496
SGTC_3285 9112818 20.8695 µM -0.665544711551895 0.272691688062535 no 2456 0.252851077867416 833 17017947 YPR165W RHO1
SGTC_2826 7992541 19.48 µM -0.665851287350261 0.272592289503558 no 2457 0.252753079621551 876 2985066
SGTC_3263 9137018 49.47 µM -0.667434650806401 0.272079215035816 no 2458 0.252247269362041 827 43844957
SGTC_698 k064-0052 127 µM -0.668438611944904 0.271754139527993 no 2459 0.251926827659458 854 5088751
SGTC_1100 amiodarone 5.07 µM -0.66873172309809 0.271659268681586 no 2460 0.251833313739554 801 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1094 duloxetine 25.4 µM -0.672345377880249 0.270490998958967 no 2461 0.250681923796454 805 60834 A selective serotonin reuptake inhibitor.
SGTC_1998 st075797 76.8 µM -0.673015892617867 0.270274502594106 no 2462 0.250468590114777 820 24208315
SGTC_2617 dihydrotanshinone i 20.83 µM -0.673079383427479 0.270254007119036 no 2463 0.250448394609471 821 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1348 1493-0373 93.8 µM -0.673427344753461 0.270141695488449 no 2464 0.250337728487391 846 3010129
SGTC_2587 piperic acid 92.2 µM -0.673889561886238 0.269992541573267 no 2465 0.250190764382711 810 5370536
SGTC_661 1304-0007 33.6 µM -0.673959203180604 0.269970072435884 no 2466 0.250168625573723 824 3117130
SGTC_646 4092-0839 27.3 µM -0.675021660671858 0.269627396167301 no 2467 0.249831001637432 837 877796
SGTC_815 1582-0027 36.9 µM -0.675310451483163 0.269534289642925 no 2468 0.249739272557163 841 3128206
SGTC_1637 st007924 17.4 µM -0.676012000082392 0.269308176615123 no 2469 0.249516513085756 818 683336
SGTC_3213 9129884 49.47 µM -0.677309861030942 0.268890119714274 no 2470 0.249104687804272 819 17190742
SGTC_804 1595-0054 20.9 µM -0.677373564865767 0.268869608322046 no 2471 0.249084483203676 831 761523 Stimulates phospholipase C.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.677842024451078 0.26871879761026 no 2472 0.248935931193455 834 5355888
SGTC_885 0865-0106 16.8 µM -0.67817961206986 0.268610144729333 no 2473 0.248828908894177 838 2793380
SGTC_2718 lomofungin 53.02 µM -0.678703745615276 0.268441495634034 no 2474 0.248662796204031 829 5351222 A RNA synthesis inhibitor.
SGTC_2998 9066762 71.4286 µM -0.679351003948939 0.268233302491664 no 2475 0.248457743330904 834 4945196
SGTC_1194 1488-0194 225 µM -0.680912069733247 0.267731514128854 no 2476 0.247963565210131 828 1391452
SGTC_275 trichlorophene 5.69 µM -0.681622749352691 0.267503230347497 no 2477 0.247738763092835 820 62616
SGTC_645 0845-0943 5.41 µM -0.682580165575024 0.267195845348584 no 2478 0.247436085415478 814 1885106
SGTC_2949 9072542 2.23 µM -0.684384253105456 0.266617115636799 no 2479 0.246866278448566 843 16457352
SGTC_1667 st014849 34.6 µM -0.685871684980645 0.266140442421331 no 2480 0.246397013472865 827 5348460
SGTC_3296 9122258 64.045 µM -0.686082107912254 0.266073043618929 no 2481 0.24633066645727 824 4730474
SGTC_228 caffeine 993.056 µM -0.68792456776206 0.265483270223935 no 2482 0.245750142290233 805 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1179 1021-1431 9.29 µM -0.689998342879378 0.264820246869568 no 2483 0.24509761472579 844 2840958
SGTC_2892 9047358 58.44 µM -0.690022697023824 0.264812465413616 no 2484 0.245089957067383 833 6466771
SGTC_2243 6634756 200 µM -0.692222607828329 0.264110046012548 no 2485 0.244398771597123 796 885676
SGTC_540 1187-0821 17.3 µM -0.692533545208254 0.26401084203579 no 2486 0.244301163611941 836 847520
SGTC_174 3553-0389 74.3 µM -0.6926645813472 0.263969040894236 no 2487 0.244260035663951 820 738071
SGTC_2757 clomiphene 4.22 µM -0.692862936759522 0.263905771007791 no 2488 0.244197785505152 847 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2777 climbazole 1.536 µM -0.69428087752109 0.263453712409445 no 2489 0.243753040383249 837 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1957 st077035 62.4 µM -0.695719863404489 0.262995348795963 no 2490 0.243302141746713 852 705593
SGTC_2895 9054447 58.44 µM -0.696623150874152 0.262707830869515 no 2491 0.243019331853092 851 2697450
SGTC_2161 5662504 8.5105 µM -0.698605977998754 0.262077258049761 no 2492 0.242399153384958 826 2859334
SGTC_3239 9133757 49.47 µM -0.699649355817926 0.261745757901231 no 2493 0.242073155684207 862 17036923
SGTC_2947 9072639 7.68 µM -0.702883923740831 0.260719445660069 no 2494 0.241064045283856 863 16488146
SGTC_3102 9121669 49.47 µM -0.70380591842128 0.260427281083373 no 2495 0.240776823735385 847 41905072
SGTC_1714 st033236 13.627 µM -0.703980841704065 0.260371869879739 no 2496 0.240722352323328 844 2916566
SGTC_2448 5185112 27.17 µM -0.704550517611643 0.2601914532881 no 2497 0.240545000758932 818 5718189
SGTC_689 0833-0039 98 µM -0.705915825960142 0.25975932198214 no 2498 0.240120242547435 876 5374726
SGTC_62 0180-0423 3.232 µM -0.705950346196606 0.25974840084623 no 2499 0.240109508331162 855 30102 YGL099W LSG1
SGTC_2108 5365811 200 µM -0.707534372191839 0.259247519004646 no 2500 0.239617230124832 828 780283
SGTC_1026 k007-1105 30.6 µM -0.708219696935843 0.259030968580085 no 2501 0.239404418089313 826 7066794
SGTC_122 0236-0016 402.397 µM -0.709392034689812 0.258660747705532 no 2502 0.239040614666262 851 6808838
SGTC_857 0438-0306 1.35 µM -0.709398424421369 0.258658730597641 no 2503 0.239038632613753 832 4686136
SGTC_2365 9042475 200 µM -0.709398528914029 0.258658697611508 no 2504 0.239038600200895 838 6464479
SGTC_664 1222-0054 14.9 µM -0.709791771439414 0.25853457465158 no 2505 0.238916636269162 835 6813991
SGTC_963 1269-2853 151 µM -0.711427310297175 0.258018664774015 no 2506 0.238409740166194 819 3668223
SGTC_2968 9090663 33.37 µM -0.711558877503915 0.25797718679335 no 2507 0.238368989668456 856 25236811
SGTC_1149 3909-7961 23.3 µM -0.711907087754146 0.25786742645047 no 2508 0.238261156423069 832 735261
SGTC_384 k007-0144 5.16 µM -0.715146580180187 0.256847459412796 no 2509 0.237259236943564 852 6824886
SGTC_624 k048-0052 28 µM -0.716482082827853 0.256427583145792 no 2510 0.236846863495125 838 6835531
SGTC_177 1327-0068 8.361 µM -0.716880444173962 0.256302409345375 no 2511 0.236723934741954 841 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_678 1218-2179 85.9 µM -0.717091610144973 0.256236069322484 no 2512 0.236658786103737 867 6820081 YOR116C RPO31
SGTC_2806 7952793 58.44 µM -0.717226676261069 0.256193641568451 no 2513 0.23661712086176 853 2972490
SGTC_377 3970-0964 33.1 µM -0.717672602829072 0.256053590536039 no 2514 0.236479589941993 833 16481235
SGTC_1789 tunicamycin 25 nM -0.718376900946258 0.255832474777039 no 2515 0.236262462729805 853 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2561 acetosyringone 100 µM -0.719320518896094 0.255536380384225 no 2516 0.235971728053769 861 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2739 tacrine 100.86 µM -0.719398592637458 0.255511889934373 no 2517 0.235947681873398 825 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2855 9016525 58.44 µM -0.720195070971216 0.255262117848323 no 2518 0.235702449152309 842 43811474
SGTC_1437 4092-1038 11.6 µM -0.720568205563451 0.255145148412498 no 2519 0.235587610766026 839 3977136
SGTC_3158 9100007 49.47 µM -0.722078934267633 0.254671855051217 no 2520 0.235122974454474 855 19297233
SGTC_3341 9147222 25.867 µM -0.723749548009744 0.254149007442701 no 2521 0.234609754117669 847 1939759
SGTC_1188 1403-0014 4.57 µM -0.725093885001945 0.253728682961327 no 2522 0.234197217798968 838 9614867
SGTC_2519 cryptotanshinone 88.04 µM -0.725716185244071 0.253534236346501 no 2523 0.234006388766863 827 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1873 rapamycin 2 nM -0.727906316970614 0.252850521476214 no 2524 0.233335468001729 834 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1410 3909-8106 77.9 µM -0.728931023023969 0.252530962560264 no 2525 0.233021928410445 851 1039210
SGTC_2242 6630449 61.2675 µM -0.730055263121008 0.252180608480819 no 2526 0.232678202717045 848 691249 YDR170C SEC7
SGTC_476 mead acid 10 µM -0.730060038699984 0.2521791207838 no 2527 0.232676743230638 871 5312531 An omega 9 fatty acid.
SGTC_1185 1319-0113 81.3 µM -0.730206787148595 0.252133407697665 no 2528 0.232631897250608 850 4672763
SGTC_310 1273-0058 1.06 µM -0.734100784701947 0.250922000941654 no 2529 0.231443657668337 814 2734232
SGTC_2199 6590217 200 µM -0.73518565982595 0.250585050222603 no 2530 0.231113215626613 809 703109
SGTC_1884 5633444 25 µM -0.736010483683272 0.250329029165844 no 2531 0.230862158866503 845 5724239
SGTC_119 0121-0043 24.815 µM -0.736710452763113 0.250111871209339 no 2532 0.230649224442392 857 1092378
SGTC_2508 celastrol 40.54 µM -0.738323815482873 0.249611723455082 no 2533 0.230158848865297 814 122724 Celastrol is a natural product and antioxidant.
SGTC_2649 anisomycin 9.56 µM -0.740990992686159 0.248786056306398 no 2534 0.229349450866698 846 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.741210424352305 0.248718192539103 no 2535 0.229282931894453 842 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3320 9137005 35.139 µM -0.742095577135889 0.24844454090685 no 2536 0.229014714685805 837 4908713
SGTC_2253 7938677 135.83 µM -0.742457279055038 0.248332764239474 no 2537 0.228905163185474 854 2301972
SGTC_379 3970-0972 5.9 µM -0.744085901579091 0.247829803660139 no 2538 0.228412254000497 859 2898042 YBL034C STU1
SGTC_2774 tamoxifen 10.92 µM -0.7457156760325 0.247327032230005 no 2539 0.227919593775802 855 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2810 7959871 45.46 µM -0.745897230130947 0.247271058121654 no 2540 0.227864749297872 848 2974535
SGTC_1759 st043059 70 µM -0.746513623004479 0.247081071415376 no 2541 0.227678602661184 875 669426
SGTC_737 1950-0117 57.9 µM -0.747780564381311 0.246690815763516 no 2542 0.227296263543501 856 5393513
SGTC_1347 1493-0251 600 nM -0.747934686074898 0.24664336422466 no 2543 0.227249777205592 824 3986378
SGTC_1303 1160-0052 261 µM -0.748563235956144 0.246449894668723 no 2544 0.227060248859649 837 3562476
SGTC_59 0330-0160 1.33 µM -0.749291532157529 0.246225824637748 no 2545 0.226840755236742 862 4293482
SGTC_3056 9094900 49.47 µM -0.749512729351153 0.246157792006553 no 2546 0.226774114618736 853 25236784
SGTC_962 1254-0300 21.5 µM -0.751051577303185 0.245684774573956 no 2547 0.226310807989419 823 7340576
SGTC_1679 SEC14.276 6.7 µM -0.751667728924839 0.245495516278631 no 2548 0.226125450957396 847 1005053 YMR079W SEC14
SGTC_652 0437-0092 114 µM -0.752085591637518 0.245367209366045 no 2549 0.225999794061093 838 3091274
SGTC_1288 0973-0013 65.5 µM -0.753679765014767 0.244878041374546 no 2550 0.225520767580306 851 4315430
SGTC_2653 dihydrofissinolide 100 µM -0.753720729658894 0.244865478399247 no 2551 0.225508465863976 862 6857746
SGTC_496 calpeptin 138 µM -0.754886742417137 0.24450803286172 no 2552 0.225158470577207 839 73364 A calpain inhibitor.
SGTC_666 0272-0154 136 µM -0.755831385661027 0.24421865520727 no 2553 0.224875148274188 864 6870312
SGTC_2689 tacrolimus 100 µM -0.755911814832757 0.244194025438381 no 2554 0.22485103487976 841 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1643 st009866 20.2 µM -0.75613375040768 0.244126069209939 no 2555 0.224784504187515 831 3156273 YOR207C RET1
SGTC_1689 st020265 53.493 µM -0.756506514623017 0.244011952507527 no 2556 0.224672783992998 856 5758320 YPR016C TIF6
SGTC_2342 7990637 118.86 µM -0.757752710041049 0.243630655698146 no 2557 0.224299518726321 866 2033102 YER133W GLC7
SGTC_1669 st015249 58.4 µM -0.758883637052673 0.243284906083978 no 2558 0.22396108402842 870 722793
SGTC_623 k072-0108 16.9 µM -0.759241556444896 0.243175537416501 no 2559 0.223854035608866 865 5382803
SGTC_1962 st076595 64.5 µM -0.759877785056559 0.242981192033992 no 2560 0.223663820808089 855 279619
SGTC_1447 4239-0816 81.9 µM -0.761291481025621 0.242549658742469 no 2561 0.223241493870285 849 1341554
SGTC_326 k292-0812 17.5 µM -0.761292036669308 0.242549489212852 no 2562 0.223241327966812 857 3579357
SGTC_2058 5236698 133 µM -0.762121850765669 0.24229638048301 no 2563 0.222993641322531 845 766665
SGTC_2244 6635614 200 µM -0.763232889969802 0.24195771711628 no 2564 0.222662258544637 872 836499
SGTC_2338 7999974 200 µM -0.764557844944636 0.241554184549853 no 2565 0.222267439665187 867 315925
SGTC_1241 0364-0022 50.8 µM -0.765068644994805 0.241398711296666 no 2566 0.222115334822922 881 4563895
SGTC_1015 4130-4525 82 µM -0.766920452478373 0.240835528927984 no 2567 0.221564406319628 866 1363237
SGTC_2792 7535235 81.82 µM -0.767408762194233 0.240687140554697 no 2568 0.221419260257051 861 1281891
SGTC_261 5-fluorouridine 15.376 µM -0.767465723816274 0.240669834203279 no 2569 0.221402332423053 846 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1813 st051246 8.6015 µM -0.767548388138209 0.240644719939892 no 2570 0.221377767586312 840 5291959
SGTC_3206 9114350 49.47 µM -0.767744658154366 0.240585096823885 no 2571 0.221319449503212 849 17087243
SGTC_3301 9125354 19.7965 µM -0.768542356682681 0.240342853899497 no 2572 0.221082518262861 832 41905162
SGTC_3121 9125696 49.47 µM -0.770010794443706 0.239897270366479 no 2573 0.220646744780569 892 1235365
SGTC_3104 9120930 49.47 µM -0.770044468696603 0.23988705752077 no 2574 0.220636757386282 856 17014836
SGTC_165 k038-0023 64.381 µM -0.771718613636821 0.239379616050202 no 2575 0.220140551926383 873 46368543
SGTC_2858 9025781 8.96 µM -0.77397488582623 0.238696657494154 no 2576 0.219472821466616 842 4894980 YPL153C RAD53
SGTC_1440 4100-1550 40 µM -0.775187572199611 0.238330026386117 no 2577 0.219114415358705 866 742806
SGTC_1554 st069299 38.7 µM -0.775481041551796 0.238241348258295 no 2578 0.219027731903836 827 24207999
SGTC_1320 1313-0481 95.3 µM -0.776214061345224 0.238019929416 no 2579 0.218811302492168 862 6813365 YLR208W SEC13
SGTC_465 cgp-37157 41 µM -0.777294473920783 0.237693781499825 no 2580 0.218492527304675 838 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1981 st071826 47 µM -0.777725642355879 0.237563691658307 no 2581 0.21836538597079 849 11838600
SGTC_1745 st081495 74 µM -0.778313264171114 0.23738646046844 no 2582 0.218192178886805 845 13842402 YBL026W LSM2
SGTC_2403 6032726 181.2 µM -0.779816169048091 0.23693350343278 no 2583 0.217749543838211 875 2881040
SGTC_2231 micatex 6.853 µM -0.779874491055309 0.236915935479012 no 2584 0.217732377307456 874 20737 An antifungal of unknown mechanism.
SGTC_1221 2958-7315 257 µM -0.779935391481889 0.236897591609287 no 2585 0.217714452676693 866 4562705
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.780089398548127 0.23685120649303 no 2586 0.217669128060702 869 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1164 k060-0068 93.7 µM -0.780357621112348 0.236770432936302 no 2587 0.217590202573898 865 5963676
SGTC_2992 9074591 71.4286 µM -0.781204407486068 0.236515527922067 no 2588 0.217341140936242 870 17741321
SGTC_602 3130-1533 38.1 µM -0.781427715978896 0.236448331354156 no 2589 0.217275487610167 867 720941
SGTC_1492 4158-0558 28.5 µM -0.781618190600397 0.236391023250555 no 2590 0.217219496587511 842 3967268
SGTC_526 4469-0568 170 µM -0.781722119937355 0.236359757253161 no 2591 0.217188949523803 866 2901964
SGTC_723 4182-0001 115 µM -0.782537187592099 0.236114632076367 no 2592 0.216949469697643 883 744821 YLR208W SEC13
SGTC_2560 caryophyllene 100 µM -0.782654064839704 0.236079493649203 no 2593 0.216915141821908 871 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_279 1273-0055 2.93 µM -0.78281299684192 0.236031716341045 no 2594 0.216868467132831 886 2847562
SGTC_353 1988-1175 58.3 µM -0.783676475982354 0.235772234880462 no 2595 0.21661498456961 874 2788357
SGTC_1915 st067105 30.6 µM -0.784002081386664 0.235674429055641 no 2596 0.216519444504478 860 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_82 0054-0107 293.755 µM -0.784191197434502 0.235617632376632 no 2597 0.216463964729884 858 3104697
SGTC_2024 5144227 134 µM -0.784518478031047 0.235519358977763 no 2598 0.216367971937847 855 3475211
SGTC_1567 st069303 68.4 µM -0.786094441736335 0.235046457035286 no 2599 0.215906080190893 873 5581319
SGTC_2936 9038235 15.59 µM -0.786475683116004 0.234932136173363 no 2600 0.21579442984439 851 4749415
SGTC_3245 9134821 49.47 µM -0.787856220703967 0.23451841876858 no 2601 0.215390405725075 884 17014901
SGTC_769 0302-0231 76 µM -0.789382295277447 0.234061556445885 no 2602 0.21494430028254 877 571869 YER009W NTF2
SGTC_455 paf C-16 10 µM -0.791935224978194 0.233298386800186 no 2603 0.214199223252964 862 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_928 2764-0428 58.7 µM -0.79291595184465 0.233005577066417 no 2604 0.213913396378781 869 662578
SGTC_1591 genipin 88.4 µM -0.793010225115364 0.232977441218146 no 2605 0.213885932711625 896 442424 A DNA cross-linking agent.
SGTC_3210 9128157 49.47 µM -0.793390686721928 0.232863911665578 no 2606 0.213775117588805 876 17590849
SGTC_266 formosanin C 406 nM -0.794477462259805 0.232539787737968 no 2607 0.21345876222201 851 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2591 skatole 100 µM -0.795907657581891 0.232113623570673 no 2608 0.213042855031938 877 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2018 5133068 143 µM -0.796302950149109 0.231995912522806 no 2609 0.212927985634996 879 785362
SGTC_1361 1608-0041 5.61 µM -0.796889275258053 0.231821376634306 no 2610 0.212757670031453 862 X1361
SGTC_1534 6-azauridine 81.6 µM -0.797271831947844 0.231707537495512 no 2611 0.212646587926628 867 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_391 gliotoxin 8.33 µM -0.797932352090098 0.231511056845854 no 2612 0.212454873954928 895 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1325 1431-0015 227 µM -0.801768238348856 0.230371858448571 no 2613 0.211343517273929 869 1103340
SGTC_63 0099-0242 26.702 µM -0.801993520219532 0.230305050828801 no 2614 0.211278353260813 877 3898502 YLR359W ADE13
SGTC_757 1066-0008 322 µM -0.802347256537726 0.230200171747575 no 2615 0.211176056851715 859 6842497
SGTC_1213 1315-0166 115 µM -0.803891340758197 0.229742680051523 no 2616 0.210729865721353 863 768401
SGTC_3280 9140961 49.47 µM -0.805292405965427 0.229328003973115 no 2617 0.210325481493427 900 4901226
SGTC_2440 5628896 157.78 µM -0.805498998592936 0.22926689385566 no 2618 0.210265892003278 887 5522048
SGTC_729 4092-0585 94.1 µM -0.808411398447138 0.228406377970137 no 2619 0.209426896195501 869 2169061
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.809749181789965 0.228011717227366 no 2620 0.209042172545422 863 6708514
SGTC_1411 3909-8223 150 µM -0.809931944686205 0.227957829966426 no 2621 0.208989645391094 875 X1411
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.810255935568982 0.227862319536255 no 2622 0.208896547573247 879 165506
SGTC_2969 9091408 28.7 µM -0.810721198716979 0.227725202343224 no 2623 0.208762898332701 879 4286311
SGTC_867 0518-0118 155 µM -0.813850380987332 0.226804211983426 no 2624 0.207865334518755 872 6848158
SGTC_3325 9138760 55.175 µM -0.814010263191547 0.226757211467007 no 2625 0.207819535736508 858 43844959
SGTC_2333 9017922 200 µM -0.814098931788387 0.226731147959426 no 2626 0.207794138895118 885 3163164
SGTC_2626 ethyl orsellinate 100 µM -0.814573831186521 0.226591583412724 no 2627 0.207658147368336 891 75653 A natural product.
SGTC_2325 6158266 200 µM -0.81478666269232 0.226529051731566 no 2628 0.207597218303628 872 3623240
SGTC_2394 5221648 200 µM -0.814929495187542 0.226487091810373 no 2629 0.20755633436842 891 788586
SGTC_157 1348-1695 65.819 µM -0.815202849157194 0.226406800815403 no 2630 0.20747810363501 871 5380510
SGTC_2208 7283366 200 µM -0.81640814771089 0.226052965817696 no 2631 0.207133369078816 852 898663
SGTC_2811 7967822 32.47 µM -0.817040468363388 0.225867462877921 no 2632 0.206952650900744 871 2232244
SGTC_1952 st077036 64.1 µM -0.817320684085142 0.225785283956822 no 2633 0.206872594678972 885 2937007
SGTC_2280 7785178 200 µM -0.818341108344981 0.225486166897987 no 2634 0.206581219554121 867 2954328
SGTC_3159 9100096 49.47 µM -0.820481961722268 0.224859347859363 no 2635 0.205970704119519 871 25236875
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.820601367424152 0.224824416252436 no 2636 0.20593668427185 874 676296 Flavone; oxidizing agent.
SGTC_3185 9108267 49.47 µM -0.821511282506944 0.224558325719828 no 2637 0.205677550093491 872 4910486
SGTC_918 glabranin 770.725 nM -0.821976428427386 0.224422370065325 no 2638 0.205545156249666 875 124049 Also referred to as licorice root.
SGTC_1910 st062352 60.4 µM -0.822249846975434 0.224342475448999 no 2639 0.205467357121553 883 2245730
SGTC_943 3253-1379 105 µM -0.823939527895156 0.22384909841347 no 2640 0.204986959575827 869 668464
SGTC_2607 solasodine 47.35 µM -0.824378815991659 0.223720929912693 no 2641 0.20486217389056 891 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2023 5144124 124 µM -0.82573893085453 0.22332436188505 no 2642 0.204476101534421 873 2830192
SGTC_1687 st020778 55.3625 µM -0.826196783082381 0.223190956187143 no 2643 0.204346236398095 870 4259299
SGTC_2937 9044753 11.33 µM -0.827242804191841 0.222886344338961 no 2644 0.204049727428574 856 6465530 YGL099W LSG1
SGTC_1668 st014914 51.6 µM -0.82907647026166 0.222352934290857 no 2645 0.203530568639092 881 2839556
SGTC_281 1672-3440 14.9 µM -0.82914003238323 0.22233445725613 no 2646 0.203512586680754 875 6833000
SGTC_1617 st002906 78 µM -0.830437096408383 0.221957601773234 no 2647 0.203145849500544 895 5150859
SGTC_1021 4476-0760 85.3 µM -0.830544629051832 0.221926375081296 no 2648 0.203115463001737 900 746768
SGTC_2477 5967686 25.23 µM -0.831136405834459 0.221754572337453 no 2649 0.20294828769764 889 776118
SGTC_833 3852-0053 558 µM -0.832310320890716 0.22141399002913 no 2650 0.202616903236235 913 3123681
SGTC_3167 9103034 49.47 µM -0.832667925677776 0.221310299340277 no 2651 0.202516019288405 871 5127859
SGTC_1076 itraconazole 331 nM -0.832801626270886 0.221271538797881 no 2652 0.202478308704953 874 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_522 1273-0010 11.6 µM -0.836652481068667 0.220156822300636 no 2653 0.201393968385669 854 5705015
SGTC_357 1325-0123 420 µM -0.836848348901941 0.220100210159861 no 2654 0.20133890825078 907 1098503
SGTC_3173 9105693 49.47 µM -0.837995850884653 0.219768712768946 no 2655 0.201016516883613 901 17096658
SGTC_139 0099-0334 718.624 µM -0.839630726833334 0.219296915236272 no 2656 0.200557732762482 904 97690
SGTC_2210 7115885 190.385 µM -0.839783700623847 0.219252799390994 no 2657 0.200514836960425 892 2927039
SGTC_2789 5281112 71.43 µM -0.842420462902043 0.218493190251315 no 2658 0.199776321482917 885 765948
SGTC_1979 st071809 45.3 µM -0.845353961441912 0.217649879714074 no 2659 0.198956620531153 905 4976333
SGTC_58 0957-0393 9 µM -0.847230000897305 0.2171115493993 no 2660 0.198433467236522 881 6997992
SGTC_3256 9138902 49.47 µM -0.847808995772819 0.216945562056224 no 2661 0.198272176195738 903 17228773
SGTC_2897 9048598 12.99 µM -0.848338068259885 0.216793950713512 no 2662 0.198124861283618 892 6467404
SGTC_2009 4012297 12.05 µM -0.848654301350586 0.216703360021399 no 2663 0.198036840923888 883 45595307
SGTC_603 3794-0023 45.9 µM -0.850123807732578 0.216282680668884 no 2664 0.19762812825522 904 3802260
SGTC_2749 bexarotene 57.39 µM -0.850717818379137 0.2161127659923 no 2665 0.197463061342095 895 82146 An retinoic acid receptor inhibitor.
SGTC_1081 sertraline 6 µM -0.852033066368189 0.215736819110078 no 2666 0.197097869837291 878 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3227 9130768 49.47 µM -0.852041852854246 0.215734308880414 no 2667 0.197095431558404 908 17720899
SGTC_1857 st056007 79.3 µM -0.852610189613457 0.215571975528301 no 2668 0.196937755010612 878 619834
SGTC_2800 7887935 81.82 µM -0.853880302630587 0.215209450809754 no 2669 0.196585657241969 905 2961002
SGTC_1963 st076565 50.3 µM -0.854282245330632 0.215094799207966 no 2670 0.196474311116743 913 4914280
SGTC_2597 laccaic acid a 100 µM -0.854357044619161 0.21507346710038 no 2671 0.196453594444216 917 5491415 A textile dye.
SGTC_178 4092-0806 87.505 µM -0.854920162391768 0.214912910238562 no 2672 0.196297673878136 866 2169044
SGTC_2320 7373003 200 µM -0.855817448235983 0.214657218843882 no 2673 0.196049381240885 872 5415828
SGTC_1256 0570-0116 285 µM -0.856706152685862 0.214404147168721 no 2674 0.195803651074215 898 410638
SGTC_1062 mesoridazine 14.2 µM -0.858254839690263 0.213963550619219 no 2675 0.19537588016362 869 4078 A neuroleptic.
SGTC_1 0258-0098 57.368 µM -0.859971215120469 0.213475863564427 no 2676 0.194902454988047 848 6790032 YDR047W HEM12
SGTC_3154 9100113 49.47 µM -0.860879987528054 0.213217909551353 no 2677 0.194652072416017 898 25237525
SGTC_168 3970-0862 530.542 µM -0.862015823706638 0.21289575945715 no 2678 0.19433940514733 884 3135186
SGTC_2323 6148992 148.28 µM -0.86217459175927 0.212850751709361 no 2679 0.194295724648931 891 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3163 9099914 49.47 µM -0.862391082062362 0.212789389742738 no 2680 0.194236173155273 913 16268368
SGTC_2374 9071832 200 µM -0.862402997142141 0.212786012834839 no 2681 0.194232895914155 868 17381698
SGTC_764 1951-2361 146 µM -0.867441540869342 0.211360821701236 no 2682 0.192850064658557 880 5438930
SGTC_1519 esterone 74 µM -0.86836870966335 0.211099175249093 no 2683 0.192596259357953 891 698 A steroid.
SGTC_479 n-linoleoylglycine 10 µM -0.869368724393842 0.210817184621797 no 2684 0.192322742011932 899 6433346 An anti-infammatory.
SGTC_415 dibenzyl ketone 100 µM -0.86960724016981 0.210749959043783 no 2685 0.192257539874877 892 7593
SGTC_578 3460-0051 92 µM -0.872250826342361 0.210005707740045 no 2686 0.191535778644001 919 2876744
SGTC_1627 st003713 25.6 µM -0.872766232952615 0.209860784941046 no 2687 0.191395254120137 908 16195070 YER133W GLC7
SGTC_610 4215-0184 155 µM -0.873551525687673 0.209640088213587 no 2688 0.191181267218554 868 5605015
SGTC_107 0358-0022 2.6945 µM -0.875684440226305 0.209041348439598 no 2689 0.19060080322908 918 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1030 k029-0042 36.7 µM -0.875893760170341 0.208982643636887 no 2690 0.190543896015673 903 6080581
SGTC_1137 ixabepilone 100 µM -0.876193202163215 0.208898680548059 no 2691 0.190462505716235 884 154225 A novel microtubule stabilizer.
SGTC_835 0312-0010 67.2 µM -0.877815711070639 0.208444077161777 no 2692 0.190021868467596 904 1626196
SGTC_2353 9059630 146.67 µM -0.881605833997682 0.207384415826151 no 2693 0.188994999574262 912 4779114
SGTC_2996 9066192 71.4286 µM -0.883266797265306 0.206921040940941 no 2694 0.188546069333207 880 6472854
SGTC_2877 9040724 71.43 µM -0.885253812251639 0.206367510025945 no 2695 0.188009877458428 910 6463895
SGTC_259 usnic acid 108.925 µM -0.886120184062524 0.206126436237781 no 2696 0.187776383806544 915 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3099 9120367 49.47 µM -0.886831343206009 0.205928676258806 no 2697 0.187584855031668 903 24824940
SGTC_2929 9013348 24.6 µM -0.889201266852162 0.205270458034662 no 2698 0.186947461053074 906 2995952
SGTC_2534 helenine 20.12 µM -0.889815617791013 0.205100033554388 no 2699 0.186782449555201 881 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3241 9133421 49.47 µM -0.889864163009215 0.205086570417822 no 2700 0.186769414403971 932 17018221
SGTC_2171 5739187 198.077 µM -0.890550911269047 0.204896169510546 no 2701 0.186585072072864 881 2262761
SGTC_2200 6600604 21.907 µM -0.890678823554597 0.204860717453173 no 2702 0.186550749308933 925 2904777
SGTC_1204 4049-0315 18.3 µM -0.891940778805798 0.204511150587673 no 2703 0.186212337861202 912 588402
SGTC_1839 st053978 48 µM -0.893366752257637 0.204116577484259 no 2704 0.185830400713369 914 3788398
SGTC_1899 st063254 59.6 µM -0.894615752696158 0.203771346401145 no 2705 0.185496264031902 901 3093813
SGTC_1321 1326-2144 215 µM -0.894797146560123 0.203721237030725 no 2706 0.185447767981378 919 3513030
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.895017449269118 0.203660389118943 no 2707 0.185388880149428 906 6708760
SGTC_2043 5101342 149 µM -0.895536885124507 0.203516963125105 no 2708 0.185250078741626 908 678451
SGTC_2822 7994718 71.43 µM -0.896641222838017 0.203212235018878 no 2709 0.184955196899651 939 1018011
SGTC_94 0334-0113 514.748 µM -0.89809485202726 0.202811539762678 no 2710 0.184567491663646 899 6795178
SGTC_1054 3429-0080 167 µM -0.898769325847854 0.202625780385392 no 2711 0.18438777092112 914 1162877
SGTC_1261 0712-0010 12.7 µM -0.899253269198355 0.202492558402786 no 2712 0.184258886162143 908 2840123
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.900913211392031 0.202036000483351 no 2713 0.183817233128114 915 61125 An anti-inflammatory.
SGTC_3250 9135583 49.47 µM -0.903429827025326 0.201344995495833 no 2714 0.183148907870344 900 7699353
SGTC_953 1188-0045 9.7 µM -0.906155773449042 0.200598113610979 no 2715 0.182426704075624 906 6144426
SGTC_771 0250-0039 27.3 µM -0.906202267255368 0.20058538922138 no 2716 0.182414401601816 908 3005115
SGTC_2894 9048625 32.47 µM -0.90668169287032 0.200454208649924 no 2717 0.182287573621156 898 4092861
SGTC_1662 st014054 52 µM -0.907955979955777 0.200105788441195 no 2718 0.181950739740888 917 2838777
SGTC_2878 9043973 25.97 µM -0.908887177954827 0.199851407255324 no 2719 0.181704841325243 920 6465167
SGTC_1273 0849-0096 14.1 µM -0.908903102913883 0.199847058626773 no 2720 0.181700637882421 913 5286025
SGTC_566 0958-0068 16.5 µM -0.90935071662181 0.199724852034173 no 2721 0.181582513731517 885 6815365
SGTC_2297 7971671 152.32 µM -0.909654116308379 0.199642044033219 no 2722 0.181502474638565 902 909016
SGTC_1821 st053465 65.6 µM -0.910766682907391 0.199338563931073 no 2723 0.181209160303847 914 675086
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.912224945640406 0.198941207572566 no 2724 0.180825157352103 873 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1817 st052116 64.4 µM -0.91337643008631 0.198627781586925 no 2725 0.180522298724462 913 4361398
SGTC_1529 apigenin 74 µM -0.916599326059623 0.197752116507716 no 2726 0.179676318830968 897 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_981 1488-1094 54.9 µM -0.917932344097517 0.197390616769338 no 2727 0.179327143561528 900 3449522
SGTC_272 doxorubicin 8.13 µM -0.91864105019016 0.197198586347949 no 2728 0.179141676530277 917 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_452 diindolylmethane 8 µM -0.919698795530789 0.196912190861933 no 2729 0.178865091120156 906 3071 Inhibits expression of several cancer promoting factors.
SGTC_836 0330-0104 1.35 µM -0.923483455059662 0.195889519330139 no 2730 0.177877659267086 884 46494820
SGTC_799 1310-0557 151 µM -0.924198055616254 0.195696785919845 no 2731 0.177691603897094 928 5354492
SGTC_680 0417-1641 114 µM -0.92492531720454 0.195500755965079 no 2732 0.177502378186354 914 2835990
SGTC_141 0443-0274 32.331 µM -0.925535594068623 0.195336350751822 no 2733 0.177343688839725 839 1627241
SGTC_3199 9111318 49.47 µM -0.927741110953378 0.194742897325774 no 2734 0.17677093885467 882 8548020
SGTC_2536 dehydroabietamide 32.04 µM -0.927869794274519 0.194708305526709 no 2735 0.176737557266383 914 3983547
SGTC_2928 9011484 9.79 µM -0.928455581292072 0.194550885380637 no 2736 0.176585649315736 893 2994751
SGTC_333 3486-0131 40.1 µM -0.929248819056127 0.194337839928777 no 2737 0.176380076303077 889 6744690
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.929432242661854 0.194288596787631 no 2738 0.176332562378423 931 229346 A bile salt which induces apoptosis.
SGTC_2675 theaflavin digallate 100 µM -0.930161396459885 0.194092918378173 no 2739 0.176143762977249 920 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_143 4032-1194 15.74 µM -0.930271691953279 0.19406332952916 no 2740 0.176115215369959 914 1806963
SGTC_2640 pentamidine 10.38 µM -0.932649517104745 0.193426101461347 no 2741 0.175500478972624 881 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_427 1354-0053 47.3 µM -0.936825919441898 0.192309971298931 no 2742 0.174424055156773 938 6813657
SGTC_2888 9058547 12.99 µM -0.937165760730612 0.192219323427306 no 2743 0.174336649537462 897 16476514
SGTC_1022 4477-0945 21.3 µM -0.937918450211854 0.192018647194064 no 2744 0.174143160350144 894 4648966
SGTC_2710 st078562 53.7235 µM -0.939576529455412 0.191577035484035 no 2745 0.173717409993351 928 17250908
SGTC_181 1447-1644 8.07 µM -0.940272616461733 0.191391825705954 no 2746 0.173538871000516 953 534600
SGTC_2326 6164455 177.58 µM -0.945983860185614 0.189876366266457 no 2747 0.172078409189485 927 2888790
SGTC_192 3455-0609 60.9 µM -0.950852691717822 0.188590281188084 no 2748 0.170839580000721 914 3769639
SGTC_775 4577-0580 57.3 µM -0.951019975369417 0.188546189434516 no 2749 0.170797117880245 934 2006902
SGTC_2312 7706453 155.7 µM -0.954024908522157 0.187755247742242 no 2750 0.170035517081621 915 976098
SGTC_1934 st074720 32.6 µM -0.956758166608329 0.187037597485174 no 2751 0.169344665813309 904 17250992
SGTC_3338 9144300 39.5675 µM -0.95703315939641 0.186965488843166 no 2752 0.169275259232749 911 4901274
SGTC_3115 9123671 49.47 µM -0.957044783811296 0.18696244106665 no 2753 0.169272325700367 938 3286988
SGTC_1420 4'-methoxyflavone 42 µM -0.957617305559669 0.186812371050452 no 2754 0.169127884743042 901 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3340 9146634 11.102 µM -0.957810145594646 0.186761840402479 no 2755 0.169079251141221 887 4907387
SGTC_2409 alverine citrate 63.97 µM -0.958014632671329 0.186708267076493 no 2756 0.16902769000716 908 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_475 α-linolenic acid 10 µM -0.95865545239189 0.186540441109214 no 2757 0.168866173619561 908 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1485 3909-9022 254 µM -0.959447208285096 0.186333215131342 no 2758 0.168666751283772 941 714516
SGTC_1457 k015-0032 57.3 µM -0.96720162327384 0.184311200744695 no 2759 0.166721625435432 925 4302660
SGTC_2395 5646831 180.19 µM -0.971012445212375 0.183322526766204 no 2760 0.165771040625281 952 6808628
SGTC_1242 0402-0103 60.1 µM -0.972513832141803 0.182933918935812 no 2761 0.165397493472539 918 432868
SGTC_137 0438-0332 85.389 µM -0.973717802623264 0.182622663864731 no 2762 0.165098337712277 925 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1307 1187-1599 12.2 µM -0.97687191438996 0.181808820010743 no 2763 0.164316283847127 917 1538471
SGTC_125 0133-0007 11.75 µM -0.977051904997592 0.18176244622456 no 2764 0.164271728202461 907 26541
SGTC_2619 obliquin 87.91 µM -0.978823393736457 0.1813064248588 no 2765 0.163833624342479 909 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2801 7907800 81.82 µM -0.983439748541443 0.180121440282296 no 2766 0.162695527712649 907 6620925
SGTC_772 k072-0172 35.3 µM -0.987064017073529 0.179194532008479 no 2767 0.161805628175134 894 5861980
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.987407933951033 0.179106731239539 no 2768 0.161721348222746 912 6312947
SGTC_144 4161-2749 112.381 µM -0.98784961326678 0.178994011768348 no 2769 0.16161315267057 910 797501 YMR168C CEP3
SGTC_621 3584-0052 32.1 µM -0.989642155594212 0.178537001497447 no 2770 0.161174528721632 923 2273927
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.992635954031022 0.177775370272587 no 2771 0.160443698346721 939 688798
SGTC_2279 7948423 32.93 µM -0.992895126243097 0.177709532629323 no 2772 0.160380532578639 917 1247112
SGTC_2661 dactinomycin 12.96 µM -0.996761808538171 0.176729104876233 no 2773 0.159440070101856 923 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3310 9130229 44.1445 µM -0.998229846736167 0.176357769572416 no 2774 0.159083958299704 940 7761258
SGTC_1594 piperine 70.1 µM -0.999158708714594 0.176123072250688 no 2775 0.158858907423242 929 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3019 9081971 49.47 µM -1.00064542708664 0.175747831986106 no 2776 0.158499129871287 939 16451803
SGTC_432 NS 1619 61.3 µM -1.00164429133876 0.175496008315956 no 2777 0.158257710672147 913 4552 A K+/calcium channel activator.
SGTC_1422 4031-0024 15.5 µM -1.00207262217243 0.175388091927086 no 2778 0.15815425976677 940 782427
SGTC_1238 0333-0287 48.8 µM -1.00207605610102 0.17538722693135 no 2779 0.15815343058017 926 7226
SGTC_2903 5923464 63.88 µM -1.00509621451098 0.174627505956622 no 2780 0.157425261359863 935 2876576
SGTC_1123 mangostin 811.285 nM -1.00581730817756 0.174446424289273 no 2781 0.157251729908565 879 5281650 An antioxidant.
SGTC_2961 9083290 32.55 µM -1.00688824950268 0.174177708775063 no 2782 0.156994239674488 926 17741490
SGTC_1098 clofazimine 15.1 µM -1.00923398925111 0.173590046633596 no 2783 0.156431214721182 944 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_589 1227-0070 34.1 µM -1.0096020046664 0.173497964874529 no 2784 0.156343004402564 918 2841384
SGTC_1328 1441-0025 69.2 µM -1.01356615204144 0.172508060463637 no 2785 0.155394907816228 929 4562601
SGTC_1661 st013063 9.66 µM -1.01435525761551 0.172311440194927 no 2786 0.155206632859267 952 721395
SGTC_2674 ligustilide 100 µM -1.0145678460589 0.172258494304135 no 2787 0.155155936532746 930 5319022 A signalling regulator.
SGTC_376 3970-0862 59.1 µM -1.01720473262796 0.171602631608048 no 2788 0.154528022560689 938 3135186
SGTC_2069 5228469 200 µM -1.01804732252949 0.171393394253021 no 2789 0.154327733732358 947 2835210
SGTC_1143 3454-2408 5.08 µM -1.01912235245233 0.171126672757608 no 2790 0.154072441803759 898 X1143
SGTC_1281 0884-0031 11.8 µM -1.01917383337476 0.171113906689927 no 2791 0.154060223424071 941 1548255
SGTC_378 3970-0959 8.33 µM -1.01971718922049 0.170979204257799 no 2792 0.153931303517766 945 6615653
SGTC_2528 xanthyletin 44.79 µM -1.02403603644755 0.169910939577668 no 2793 0.152909127080281 959 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_16 erodoxin 22.806 µM -1.02563479887601 0.169516574069686 no 2794 0.152531879085518 935 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1287 0971-0001 34.6 µM -1.02693570456661 0.16919611438285 no 2795 0.152225370199286 916 4665869
SGTC_1247 0448-0043 5.84 µM -1.02725941248146 0.169116433997694 no 2796 0.152149164337847 947 3089013 YGL099W LSG1
SGTC_970 1315-0089 19.5 µM -1.0300162660909 0.168438813887622 no 2797 0.151501184944907 921 6811083 YLR033W RSC58
SGTC_936 3005-4620 401 µM -1.03059791097267 0.168296071977481 no 2798 0.151364708066401 935 777207
SGTC_1660 st012960 28.1 µM -1.0330133764147 0.167704123553878 no 2799 0.150798819422591 933 24207266
SGTC_3258 9138477 49.47 µM -1.0342256086168 0.167407552599002 no 2800 0.150515352461364 959 4970355
SGTC_3138 9097216 49.47 µM -1.03430797009855 0.167387415242648 no 2801 0.15049610603415 932 25237486
SGTC_1950 st077106 7.18 µM -1.03711251204393 0.166702637254493 no 2802 0.149841712343261 925 13831864
SGTC_2844 9010103 25.97 µM -1.03984713858779 0.166036673537871 no 2803 0.149205462401746 946 2480525
SGTC_1317 1273-0028 910 nM -1.0419871995848 0.165516705130618 no 2804 0.148708806807199 919 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1752 st044819 83.042 µM -1.04213272838106 0.16548138443768 no 2805 0.148675073322271 931 441209 YML126C ERG13
SGTC_905 2-aminofluorene 215 µM -1.04222346057232 0.165459365670057 no 2806 0.148654044245443 938 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2062 5245942 200 µM -1.04292667575498 0.165288774616237 no 2807 0.148491126895091 961 1376160
SGTC_2166 5933061 31.504 µM -1.04735186930115 0.164217891734028 no 2808 0.147468660738827 944 2877375
SGTC_1949 st076024 69.1 µM -1.04997600648206 0.163584988776409 no 2809 0.14686457212664 946 2921930
SGTC_2 0422-0095 29 µM -1.05025233350929 0.16351843509139 no 2810 0.146801057093028 923 6790840
SGTC_381 3461-2219 42.7 µM -1.05165644060633 0.163180525994725 no 2811 0.146478601388934 965 2883159
SGTC_2865 9030313 51.95 µM -1.05181976963682 0.163141249099233 no 2812 0.146441123478505 954 42562754
SGTC_89 0302-0250 142.109 µM -1.05453955791633 0.162488105344144 no 2813 0.145817979799754 965 4203518 YLR208W SEC13
SGTC_754 3474-0146 171 µM -1.05601654213918 0.162134128787777 no 2814 0.145480328671914 929 24762078
SGTC_1057 3448-5381 134 µM -1.05764488747641 0.161744459197083 no 2815 0.145108684991274 900 5497911
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.0588835827208 0.161448443516691 no 2816 0.144826400961686 946 688664
SGTC_3083 9117465 49.47 µM -1.05897339670841 0.161426994073242 no 2817 0.144805947801132 956 16420915
SGTC_3321 9137793 26.8275 µM -1.0590834128326 0.16140072247291 no 2818 0.144780896698987 940 4904192
SGTC_840 0245-0196 390 µM -1.05942537900023 0.161319079533916 no 2819 0.144703048299676 937 3827528
SGTC_1856 st057054 55.7 µM -1.0597118303639 0.161250711249463 no 2820 0.144637859516651 953 1266018
SGTC_1775 st081588 35.1725 µM -1.0604564736835 0.161073073236759 no 2821 0.144468490883096 926 1426443 YGL099W LSG1
SGTC_2695 st077686 51.995 µM -1.06223750220774 0.160648719056949 no 2822 0.144063939374178 952 2876092
SGTC_659 k018-0002 107 µM -1.06312599001169 0.160437298028714 no 2823 0.143862409799092 953 6797879 YHR007C ERG11
SGTC_2952 9073731 13.78 µM -1.06648014055899 0.159640797056911 no 2824 0.143103325700669 971 16457353
SGTC_3092 9117248 49.47 µM -1.06855502715177 0.15914937713434 no 2825 0.142635111271483 987 17141857
SGTC_1108 betulinic acid 729.144 nM -1.06904524545908 0.159033417803571 no 2826 0.142524641113659 934 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_573 3702-0553 84.7 µM -1.06914528811929 0.159009759884709 no 2827 0.142502103721145 940 1222756
SGTC_3112 9123419 49.47 µM -1.07119000200812 0.158526734634521 no 2828 0.142042003080826 967 17015854
SGTC_872 0588-0139 234 µM -1.07415292036144 0.157828510165092 no 2829 0.141377074603582 933 2047100
SGTC_2192 5915882 198.485 µM -1.07776872218581 0.15697917130908 no 2830 0.14056849056047 937 2876149
SGTC_1380 2291-0730 164 µM -1.07780313515244 0.156971102298006 no 2831 0.140560810068199 956 2999191
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.07908148594491 0.156671553180358 no 2832 0.140275701898209 923 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2799 7812892 81.82 µM -1.08096765127826 0.156230265721016 no 2833 0.139855751720427 948 20205235
SGTC_2222 6885208 172.143 µM -1.08109179403929 0.156201250015228 no 2834 0.139828141637257 966 609514
SGTC_2446 5162541 200 µM -1.08304331398796 0.155745590726877 no 2835 0.139394598974094 956 1549321
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.08570508344152 0.155125510147257 no 2836 0.138804745471121 932 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3332 9141069 11.198 µM -1.08586651231396 0.155087956489209 no 2837 0.13876902725926 950 17332883
SGTC_2179 6298986 200 µM -1.08671822939857 0.154889918510423 no 2838 0.138580677562131 907 738374
SGTC_489 paxilline 115 µM -1.08829072405941 0.15452472716652 no 2839 0.13823339210479 966 105008 A toxic potassium channel blocker.
SGTC_1838 st055369 84.5 µM -1.08861877742227 0.154448612867115 no 2840 0.138161016384921 943 676036
SGTC_536 3852-0578 10.6 µM -1.09101461372154 0.153893487204928 no 2841 0.137633226145417 962 2869208
SGTC_3113 9123498 49.47 µM -1.09233485515962 0.153588146539551 no 2842 0.137342972690338 972 8897275
SGTC_2165 5727197 32.143 µM -1.09395480608052 0.153214038626886 no 2843 0.136987399961627 946 1361712
SGTC_3248 9135562 49.47 µM -1.0954486444769 0.152869590472256 no 2844 0.136660066391531 947 17650701
SGTC_1006 4099-6547 255 µM -1.09552501826024 0.152851994069856 no 2845 0.136643345561402 963 3146833
SGTC_3022 9087993 49.47 µM -1.09656061274781 0.152613527276419 no 2846 0.136416756636111 953 17173644
SGTC_1011 4112-3381 17.4 µM -1.09810673204662 0.152257961279326 no 2847 0.136078943029 945 2877139
SGTC_1898 st060199 18.6 µM -1.09842568801934 0.152184678441094 no 2848 0.136009325233974 935 688866
SGTC_2430 5571206 200 µM -1.10006314417536 0.151808827801058 no 2849 0.135652305328051 953 1731771
SGTC_2197 6588183 93.1375 µM -1.10189716614084 0.151388591662184 no 2850 0.135253190376283 938 884136
SGTC_236 1509-0011 5.31 µM -1.10475653264587 0.150734959219732 no 2851 0.134632549975112 960 3107280
SGTC_1480 1070-0044 41.2 µM -1.1065218473409 0.150332359388687 no 2852 0.134250356584978 949 3124987
SGTC_2072 5231554 129 µM -1.10959853692566 0.14963239993396 no 2853 0.133586031012205 953 789545
SGTC_2516 gossypol 71.55 µM -1.11154671768449 0.149190307067437 no 2854 0.133166546336496 971 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_966 1300-0360 30.2 µM -1.11173034691797 0.149148681850191 no 2855 0.133127053865614 914 70588
SGTC_1802 st050112 57.9 µM -1.11188121622464 0.149114488483343 no 2856 0.133094612985405 958 4662563
SGTC_1970 st070122 35.8 µM -1.11193600839103 0.149102071556812 no 2857 0.133082832571422 960 102928
SGTC_1891 st059073 26.2 µM -1.11278171889295 0.148910505383286 no 2858 0.132901094322739 953 688754
SGTC_2666 tannic acid 100 µM -1.11553313022547 0.148288407511157 no 2859 0.132311014730199 938 16134267 A thiamine antagonist.
SGTC_1530 rhein 70.4 µM -1.11589096384531 0.148207628783425 no 2860 0.132234405090652 950 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2913 7966556 36.57 µM -1.1166561260208 0.148034996954868 no 2861 0.132070691915494 922 2976516
SGTC_2336 9001819 198.65 µM -1.12203704612858 0.146824784302826 no 2862 0.130923344405339 936 2989602
SGTC_1342 1486-1464 234 µM -1.12285638943247 0.146641091238194 no 2863 0.130749245888552 951 3253938
SGTC_707 0865-0008 204 µM -1.12302765601308 0.146602713541387 no 2864 0.130712874466149 975 723043
SGTC_2241 6772625 37.8075 µM -1.1261483352314 0.145904606990081 no 2865 0.130051368865872 948 2285411
SGTC_3208 9114115 49.47 µM -1.13159041576387 0.14469254770635 no 2866 0.128903335673787 961 650895
SGTC_631 k072-0230 41.5 µM -1.13206134094911 0.144587983075554 no 2867 0.12880432320407 973 5773147
SGTC_162 k030-0015 37.8 µM -1.13531150352634 0.143867702472493 no 2868 0.128122412008086 981 1809920 YMR134W ERG29
SGTC_1515 3460-0031 42.1 µM -1.13767021919906 0.143346496998397 no 2869 0.127629106665329 949 2876596
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.14032791366802 0.142760755672115 no 2870 0.12707485635823 993 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2001 4023502 57.655 µM -1.14364855209261 0.142031181797306 no 2871 0.126384708829495 952 108941 YCR052W RSC6
SGTC_1065 prochlorperazine maleate 2.48 µM -1.14517354196926 0.141696975098359 no 2872 0.126068638033872 969 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_551 k048-0028 34.9 µM -1.14544231767256 0.141638127252501 no 2873 0.126012988508118 967 6836383
SGTC_92 0063-0024 660.874 µM -1.14586887688228 0.141544767049625 no 2874 0.125924705356617 991 3594437
SGTC_796 1234-0020 70.7 µM -1.14925458362186 0.140805222839747 no 2875 0.125225509705144 925 46495034
SGTC_795 0685-0265 78 µM -1.15048337640391 0.140537465653882 no 2876 0.124972418570497 944 302754
SGTC_909 3448-9333 149 µM -1.15243071170468 0.140113844478175 no 2877 0.124572063407463 967 3344074
SGTC_1357 1503-1303 39.5 µM -1.15888957589153 0.138715005203822 no 2878 0.123250599231693 945 292895
SGTC_682 0kpi-0099 17 µM -1.16151204522687 0.138149764063582 no 2879 0.122716863809114 959 1714895 YML126C ERG13
SGTC_569 4130-2812 160 µM -1.16336146272336 0.137752090363017 no 2880 0.122341439110385 961 743552
SGTC_2154 5570129 200 µM -1.16766278414727 0.136830215800548 no 2881 0.121471407059979 995 673366
SGTC_2951 9072950 58.06 µM -1.16791828068442 0.136775589869566 no 2882 0.121419864753251 952 16488155
SGTC_1870 st057514 26.5 µM -1.16909268632831 0.136524690167177 no 2883 0.121183145129439 966 5393161
SGTC_1037 k284-1091 78.7 µM -1.17148292998978 0.136015011943589 no 2884 0.120702357637421 964 3334711
SGTC_234 nsc-17383 10.7 µM -1.17149078118096 0.136013339961664 no 2885 0.120700780618978 949 408974
SGTC_851 0394-0702 453 µM -1.17469396310282 0.135332367155419 no 2886 0.12005858772521 977 762646
SGTC_1334 1486-0610 236 µM -1.17515860005008 0.135233783191939 no 2887 0.119965634916725 946 3742339
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.17616131103226 0.135021201612777 no 2888 0.119765210758825 949 3256 An antibiotic and ribosome inhibitor.
SGTC_3085 9117376 49.47 µM -1.17861179836802 0.134502646389241 no 2889 0.119276395702431 954 16480349
SGTC_642 0335-0876 158 µM -1.17886322477784 0.134449518705636 no 2890 0.119226321760639 974 6812350
SGTC_1681 tripelennamine 100 µM -1.18098607205793 0.134001524605712 no 2891 0.118804128161027 932 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1364 1653-0028 37.6 µM -1.18218145387301 0.133749709660477 no 2892 0.118566854937315 963 5718652
SGTC_200 k038-0079 37.545 µM -1.18746639349526 0.132640302397188 no 2893 0.117521852449014 999 3436683
SGTC_3057 9095946 49.47 µM -1.18898282482518 0.13232314893392 no 2894 0.117223212790986 995 24540043
SGTC_2908 7930301 100 µM -1.18920378145225 0.132276980707912 no 2895 0.117179743425404 963 2223178
SGTC_3300 9124615 50.48 µM -1.18965112556722 0.132183543493621 no 2896 0.117091771233165 976 24824903
SGTC_2164 5685496 200 µM -1.1908108983729 0.131941512530381 no 2897 0.11686391475091 990 759046
SGTC_47 0149-0135 24.25 µM -1.19228025819574 0.131635313580925 no 2898 0.116575686367958 979 5239155
SGTC_2092 5303694 80.6725 µM -1.19257062877628 0.131574861520886 no 2899 0.116518787228328 968 1963699
SGTC_2887 9044784 58.44 µM -1.19259688876487 0.131569395416095 no 2900 0.116513642462311 963 6465546
SGTC_2766 oltipraz 83.91 µM -1.19495447537531 0.131079294437442 no 2901 0.116052408636945 912 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_984 1492-0255 2.91 µM -1.19884152764843 0.130274001097085 no 2902 0.115294785784971 986 1585198
SGTC_3172 9105863 49.47 µM -1.20283909339472 0.12944938925571 no 2903 0.11451929668514 1008 2348785
SGTC_3023 9089636 49.47 µM -1.20522932270042 0.128958067678921 no 2904 0.114057392734277 1009 17249241
SGTC_3043 9092303 49.47 µM -1.20601294090047 0.128797273556803 no 2905 0.113906250365277 969 25236084
SGTC_2240 6690706 185.951 µM -1.20716084628371 0.128561980904977 no 2906 0.113685102913724 971 805876
SGTC_2596 sinensetin 100 µM -1.20763942785998 0.128463971503449 no 2907 0.113592993181732 974 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2168 5727979 200 µM -1.20966256539895 0.128050223401235 no 2908 0.1132041999159 984 695210
SGTC_817 1391-0715 46 µM -1.21100201204593 0.127776805496388 no 2909 0.112947316785837 974 1353946
SGTC_3169 9102970 49.47 µM -1.21254417582923 0.127462510283016 no 2910 0.112652071567114 1011 17027839
SGTC_853 0419-0306 21 µM -1.21262191663176 0.127446680840742 no 2911 0.112637202799294 971 762713
SGTC_3077 9117319 49.47 µM -1.21295242775329 0.127379398022525 no 2912 0.112574004624824 995 17154678
SGTC_216 k038-0035 28.382 µM -1.21622502253863 0.126714522531567 no 2913 0.111949607081111 973 4444231 YPR107C YTH1
SGTC_1018 4259-0013 28.1 µM -1.21626122576971 0.126707180855954 no 2914 0.111942713531264 971 6801262
SGTC_3008 9078912 71.4286 µM -1.21720004034861 0.126516901495982 no 2915 0.111764057425546 999 16648731
SGTC_960 1222-0186 7.7 µM -1.2172669175651 0.126503354390688 no 2916 0.111751338499243 986 3126296
SGTC_633 0437-0093 97.7 µM -1.21795992229088 0.126363034112688 no 2917 0.111619601556692 980 2831118
SGTC_1227 3909-8010 46.6 µM -1.21820189463285 0.126314064869973 no 2918 0.111573629932146 977 15982272
SGTC_2152 5568786 200 µM -1.22022371293082 0.125905415500189 no 2919 0.111190039978804 981 5399883
SGTC_2418 pentamidine 31.67 µM -1.2214589425014 0.125656205416484 no 2920 0.110956150932189 924 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2956 9076196 2.52 µM -1.22271781486229 0.125402579660023 no 2921 0.110718147964163 995 16423868
SGTC_2987 9018338 71.43 µM -1.22400474981234 0.125143669706952 no 2922 0.110475217863599 969 5055682
SGTC_613 3914-0030 117 µM -1.22594945666832 0.124753135623685 no 2923 0.110108847911155 940 1145395
SGTC_1197 1601-0112 267 µM -1.22750922426233 0.124440520760054 no 2924 0.109815628494359 987 7350313
SGTC_2300 7976697 71.57 µM -1.2291081141973 0.124120633806302 no 2925 0.109515636645346 960 2236109
SGTC_1174 0739-0097 51.1 µM -1.23027618119606 0.123887304766294 no 2926 0.109296850306791 984 728447
SGTC_159 3970-0959 50 µM -1.23039644082388 0.123863299560164 no 2927 0.109274342758808 956 6615653
SGTC_2091 4-phenylthiadiazole 200 µM -1.23058374999133 0.1238259169791 no 2928 0.109239292987679 980 270010
SGTC_1193 1488-0126 41.5 µM -1.23230227010158 0.123483308690058 no 2929 0.108918096070153 961 1384710
SGTC_533 1222-0222 6.71 µM -1.23536935081282 0.122873499264415 no 2930 0.10834653705144 987 3982874
SGTC_2517 totarol 10 µM -1.23612196030946 0.122724185604251 no 2931 0.108206616564178 965 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_553 k007-0256 45.7 µM -1.23777070444576 0.122397528576384 no 2932 0.107900546954156 995 6287000
SGTC_2139 5578692 56.4705 µM -1.23823351320272 0.12230594448913 no 2933 0.107814744228148 940 650991 YMR113W FOL3
SGTC_135 0933-0004 26.348 µM -1.23858071366682 0.122237269429268 no 2934 0.107750407047603 953 21230617 YGL099W LSG1
SGTC_681 1642-0006 26.6 µM -1.24050091142285 0.121857949768465 no 2935 0.107395088645837 1014 4446530
SGTC_2369 9071472 200 µM -1.24083005316585 0.12179301356519 no 2936 0.107334268289718 978 17296037
SGTC_2930 9013230 14.89 µM -1.24267118084161 0.121430226797449 no 2937 0.106994513967041 944 2995857
SGTC_3062 9077494 49.47 µM -1.24351862605484 0.121263496721631 no 2938 0.106838390803499 869 16459633
SGTC_2529 gangaleoidin 93.61 µM -1.24913631965027 0.120162317727615 no 2939 0.105807609257541 997 4565183
SGTC_2889 9059656 51.95 µM -1.25203758079097 0.119596380607113 no 2940 0.105278085198069 996 3949838
SGTC_897 1000-0139 31.4 µM -1.25203792603713 0.119596313373425 no 2941 0.105278022299721 986 6151020
SGTC_2260 7964312 200 µM -1.25205694990518 0.119592608681846 no 2942 0.105274556496287 998 231951
SGTC_3156 9099931 49.47 µM -1.25215140232969 0.119574216297189 no 2943 0.105257350201438 987 18111053
SGTC_1518 st038567 90.8 µM -1.25318585748265 0.119372911108768 no 2944 0.105069037800879 995 77966
SGTC_439 amiodarone 34.4 µM -1.2575194371262 0.118532195329714 no 2945 0.104282802612226 975 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2643 anethole 100 µM -1.26130058823635 0.11780207641353 no 2946 0.10360028468434 1012 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1113 artemisinin 1.17947 µM -1.26233020758478 0.117603815177495 no 2947 0.103414995661421 969 2240 An anti-malaria and mitochondrial poison.
SGTC_3030 9087619 49.47 µM -1.26310846730918 0.117454112024072 no 2948 0.103275100719834 965 25236973
SGTC_2349 9023730 187.07 µM -1.26501026012871 0.117088858085211 no 2949 0.102933824960502 1004 4126287
SGTC_547 1120-0019 610 nM -1.26691283557263 0.116724259853298 no 2950 0.102593229315644 935 3676939
SGTC_607 4491-0986 66.8 µM -1.26760598755443 0.116591628589307 no 2951 0.10246934631761 942 698981 YDR232W HEM1
SGTC_950 1165-0508 94.1 µM -1.26878158894266 0.116366927386544 no 2952 0.102259486688383 984 6148369
SGTC_2313 7726885 200 µM -1.26932433236369 0.11626329263521 no 2953 0.102162705711714 981 726423
SGTC_2157 5649910 96.377 µM -1.2700987295574 0.116115537906367 no 2954 0.102024732064004 985 2858091
SGTC_2213 7173844 200 µM -1.27134774605164 0.115877506894086 no 2955 0.101802481714002 993 892728
SGTC_1436 4092-1007 8.32 µM -1.27549934072562 0.115088808203777 no 2956 0.101066278673462 963 2881121
SGTC_3333 9141820 12.094 µM -1.27624983528567 0.1149466414419 no 2957 0.100933608532824 973 1939433
SGTC_2425 5628681 7.85 µM -1.27799000329842 0.114617480768285 no 2958 0.100626475541928 991 5714958
SGTC_307 1501-1223 22.3 µM -1.28158946243079 0.113938756796973 no 2959 0.0999933493211916 996 2830329
SGTC_579 4491-1009 110 µM -1.28317604828554 0.113640496900922 no 2960 0.0997152026707573 1009 1271041
SGTC_3329 9141233 27.5565 µM -1.28450130316115 0.113391791193329 no 2961 0.0994833039517221 961 4909101 YNL103W MET4
SGTC_879 0831-1030 162 µM -1.29331445102852 0.111747731940382 no 2962 0.0979511622963513 985 1549252
SGTC_2228 7354201 200 µM -1.29807603432099 0.110866604493192 no 2963 0.0971306043399383 1012 753451
SGTC_1061 3448-9325 110 µM -1.30157793519488 0.11022176440982 no 2964 0.0965303533220603 984 723482
SGTC_1840 st055363 71 µM -1.30166755058641 0.110205298005344 no 2965 0.0965150284417704 1014 676033
SGTC_1852 st056254 31.4 µM -1.30216668959491 0.110113615854365 no 2966 0.0964297047628871 984 442583
SGTC_423 5-fluorouracil 457 µM -1.30372241564877 0.109828210234765 no 2967 0.0961641218942633 968 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_329 k048-0121 21.3 µM -1.3069863845171 0.109231145411649 no 2968 0.09560866783586 1000 6832902
SGTC_2265 7929201 200 µM -1.30795586478944 0.109054252298291 no 2969 0.0954441397566593 990 1265108
SGTC_115 0527-0192 112.043 µM -1.31048063648141 0.108594544423769 no 2970 0.0950166452830116 1004 4233931
SGTC_2925 9010536 32.5 µM -1.31386440956215 0.107980618710937 no 2971 0.0944459187845225 920 2994177
SGTC_730 1436-0052 41.2 µM -1.31431470645701 0.107899109109166 no 2972 0.0943701601124024 991 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_458 nppb 133 µM -1.31823145375963 0.107191995280398 no 2973 0.0937130895964474 1004 4549 A chloride channel blocker.
SGTC_2026 5148700 152 µM -1.31825970931578 0.107186906304562 no 2974 0.093708361768561 1003 79838
SGTC_1300 1094-0077 113 µM -1.31990173446894 0.106891468020351 no 2975 0.0934339142144468 998 5532636
SGTC_2098 5376439 882.5 nM -1.32104031570012 0.106686956145472 no 2976 0.0932439609861168 992 2844116
SGTC_337 1315-0038 354 µM -1.32152339529324 0.106600270805233 no 2977 0.0931634535115102 989 1626437
SGTC_1822 st052468 42 µM -1.32626045556256 0.105752930218584 no 2978 0.0923767202333556 991 2873678
SGTC_2694 st077685 81.9 µM -1.3263302616391 0.105740480181557 no 2979 0.0923651636779881 989 2838096
SGTC_2370 9071495 200 µM -1.32645965061738 0.105717406231055 no 2980 0.0923437458666729 1013 21791103
SGTC_293 4049-0273 38.5 µM -1.32785644146419 0.105468548091762 no 2981 0.0921127684549032 984 1380311
SGTC_3189 9110682 49.47 µM -1.32908815412027 0.105249452761607 no 2982 0.0919094439853202 1022 17122418
SGTC_1709 st033179 39.1045 µM -1.33131881839928 0.104853503910003 no 2983 0.0915420643757592 995 573381
SGTC_289 k017-0060 526 µM -1.33284320126108 0.104583542953697 no 2984 0.0912916325928415 1009 5512909
SGTC_2383 9036125 200 µM -1.33297866294603 0.104559577714792 no 2985 0.0912694029975258 1008 79580
SGTC_1917 st066507 28.5 µM -1.33584308508069 0.10405374888878 no 2986 0.0908002835348171 986 3156428
SGTC_2502 avocadyne acetate 18.59 µM -1.33899163708143 0.103499795159925 no 2987 0.0902866977176031 980 3952079
SGTC_1033 k072-0102 21.3 µM -1.3393776712381 0.103432024195922 no 2988 0.0902238773367263 980 5965931
SGTC_2051 5263410 176 µM -1.34354577413131 0.102702335569163 no 2989 0.0895476572883431 997 227584
SGTC_2755 lomerizine 42.69 µM -1.34746394499212 0.102019819564973 no 2990 0.0889154290102998 983 3949 A calcium channel blocker.
SGTC_3097 9117246 49.47 µM -1.34930110657218 0.101700938783659 no 2991 0.0886201351775195 989 16423892
SGTC_70 0141-0289 43.283 µM -1.35413932939155 0.100864629517638 no 2992 0.0878459653647247 969 352408
SGTC_2258 7960471 200 µM -1.35593822737215 0.100554963928067 no 2993 0.0875594116348309 1022 2974708
SGTC_505 gw-5074 63.9 µM -1.36283559060127 0.0993740670107099 no 2994 0.0864671658154747 1002 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2270 7924575 90.91 µM -1.36647485658498 0.0987550895983383 no 2995 0.085894983719417 987 1262135
SGTC_1190 1486-1332 13 µM -1.36680671377717 0.0986987870072689 no 2996 0.0858429489215098 992 4150046
SGTC_951 1171-0579 82.7 µM -1.37201434185592 0.0978183404763502 no 2997 0.0850294865855055 984 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.37609213960021 0.0971329422981421 no 2998 0.0843965544022164 1021 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2173 5763948 167 µM -1.37883888040666 0.0966732595819534 no 2999 0.0839722180349321 1014 2867177
SGTC_358 0075-0058 9.45 µM -1.38185252750849 0.0961707490983895 no 3000 0.0835084933780508 1028 1069125
SGTC_3098 9119039 49.47 µM -1.38253626795138 0.0960570065516016 no 3001 0.0834035512345398 992 17161528
SGTC_2575 plumbagin 510 nM -1.38583784721898 0.0955091693790819 no 3002 0.0828982113828667 990 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_191 3914-0123 66.505 µM -1.38736292594129 0.0952568880910666 no 3003 0.0826655619945528 1029 3144412
SGTC_2408 sulbentine 18.36 µM -1.38850185345274 0.0950688049186815 no 3004 0.0824921403854019 971 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1293 1000-1278 195 µM -1.38928576263709 0.094939508702791 no 3005 0.0823729357474439 1005 678847
SGTC_2366 9070441 60.58 µM -1.39016709267523 0.0947942988617339 no 3006 0.0822390718091147 996 6837235
SGTC_209 4077-0173 175.592 µM -1.39229597573585 0.0944442147529668 no 3007 0.0819163948200309 1004 15993494
SGTC_1407 3909-7909 12.3 µM -1.39358547448236 0.094232627292236 no 3008 0.0817214086850548 982 4411780
SGTC_926 2268-1401 59.4 µM -1.39476770094672 0.0940389490276922 no 3009 0.0815429508925466 1011 2931578
SGTC_306 1672-3436 11.6 µM -1.40115807463791 0.092997128781841 no 3010 0.0805834041795129 1011 6797378
SGTC_131 0141-0277 33.849 µM -1.40196201959399 0.0928666685082356 no 3011 0.0804632942966664 1026 1547771
SGTC_1479 0549-0158 134 µM -1.40206872587253 0.0928493629100056 no 3012 0.0804473624838861 1017 5440202
SGTC_1842 st055362 61.2 µM -1.40728930955184 0.0920055994151478 no 3013 0.079670809021208 1002 676032
SGTC_487 nimodipine 119 µM -1.40767004100526 0.0919442875308408 no 3014 0.0796143984691345 1041 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1464 k208-0027 110 µM -1.40949197866675 0.0916513068004939 no 3015 0.0793448718291375 993 X1464
SGTC_396 dithiazanine 1.25 µM -1.41401404916679 0.0909271152670557 no 3016 0.078678888745725 1002 10578 An antihelmenthic.
SGTC_3222 9128301 49.47 µM -1.4162985807491 0.0905628747176593 no 3017 0.0783440516030116 980 4911358
SGTC_2818 7996756 12.99 µM -1.41870168146913 0.0901808998897475 no 3018 0.0779930033988065 1030 2241621
SGTC_1366 1683-0113 21.9 µM -1.42081182574337 0.0898464786832959 no 3019 0.0776857359195829 1024 708623
SGTC_18 0111-0177 500 nM -1.42089793735935 0.0898328510899795 no 3020 0.0776732163688016 1027 721752
SGTC_1787 fluconazole 80 µM -1.42225465931596 0.089618345812733 no 3021 0.0774761681031007 975 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_539 4859-0462 2.54 µM -1.42255180145891 0.0895714168718927 no 3022 0.077433062343752 986 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2904 7225135 42.03 µM -1.42728065307641 0.0888270266961004 no 3023 0.0767495074507982 1043 4446116
SGTC_2788 5282734 71.43 µM -1.42759698187746 0.0887773967948942 no 3024 0.0767039464153904 994 743706
SGTC_1471 k673-0312 37 µM -1.42789255645182 0.0887310417587505 no 3025 0.0766613932144751 1010 24099884
SGTC_1670 st016595 4.04 µM -1.43054615054464 0.0883156849774131 no 3026 0.0762801650495182 1029 597879
SGTC_2070 5230947 200 µM -1.4313860742398 0.088184517358737 no 3027 0.0761597986357191 1028 2835538
SGTC_3140 9094243 49.47 µM -1.43659937617755 0.0873736225803275 no 3028 0.0754159304880204 1015 19291112
SGTC_2990 9074105 71.4286 µM -1.43999517830972 0.0868484296318851 no 3029 0.0749343816128337 1022 6502001
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.44165656941919 0.0865923406577548 no 3030 0.0746996406690291 1003 23665772 A membrane-active detergent.
SGTC_758 0868-0029 16 µM -1.44664178588829 0.0858273010770746 no 3031 0.0739986382956024 989 762687
SGTC_1556 plumbagin 1.48 µM -1.44955747452739 0.085382205601673 no 3032 0.0735909809849574 966 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1888 azatryptophan 97.5 µM -1.45121919845179 0.0851293092660109 no 3033 0.0733594162929496 1009 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2411 st077133 39.94 µM -1.4517034602398 0.0850557156141802 no 3034 0.0732920383891663 1017 1403142 YNL221C POP1
SGTC_1367 1812-0510 76.9 µM -1.45351630161763 0.0847806399948321 no 3035 0.0730402284480343 1007 1142582 YDR527W RBA50
SGTC_2113 5491891 107.031 µM -1.45391017056978 0.0847209636990422 no 3036 0.0729856063442085 1002 789979
SGTC_2391 6285546 200 µM -1.45489451989815 0.0845719596516059 no 3037 0.0728492325962185 1022 846083
SGTC_7 0192-1582 4.227 µM -1.4560890443557 0.0843914048555359 no 3038 0.0726840028658073 1039 252616
SGTC_755 1995-0008 37.3 µM -1.45692380438022 0.0842654009757882 no 3039 0.0725687071459254 1018 689533
SGTC_892 0929-0076 29 µM -1.45788437815103 0.0841205807685444 no 3040 0.0724362076354048 1006 5751038
SGTC_1774 st048371 48.465 µM -1.45915300629138 0.0839296034027592 no 3041 0.0722614998910208 1018 4242727
SGTC_907 3448-6986 75.5 µM -1.45929311138039 0.083908532174587 no 3042 0.0722422252889033 1012 590582
SGTC_3070 9117005 49.47 µM -1.46088446896713 0.0836694773076927 no 3043 0.0720235747576228 1053 8779016
SGTC_889 0919-1524 82.7 µM -1.46148509401617 0.0835793841147197 no 3044 0.0719411816438742 1010 3905452
SGTC_2291 7917025 104.35 µM -1.47135527888327 0.0821092891133166 no 3045 0.0705975305061508 1015 2964612
SGTC_1879 gemcitabine 100 µM -1.47549153122535 0.0814990478629017 no 3046 0.0700402217190509 1023 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1663 st014140 55.4 µM -1.47765940073614 0.0811805807773017 no 3047 0.069749483196138 1005 4207120
SGTC_1765 st044815 90.4 µM -1.4811474984283 0.0806701400732245 no 3048 0.0692836365107096 1023 645695
SGTC_1995 st072814 61.1 µM -1.48513058866138 0.0800902316954892 no 3049 0.068754617278977 1023 5769371
SGTC_1314 1222-0010 41.1 µM -1.49305246377637 0.0789462405783277 no 3050 0.0677117271823706 1030 3526027
SGTC_3326 9140064 16.379 µM -1.49648878647144 0.078453870631564 no 3051 0.0672631639500226 1025 1868434
SGTC_1990 st072050 59.8 µM -1.500544808287 0.0778757075169193 no 3052 0.0667366678372407 1024 17233948
SGTC_1550 gossypolone 36.6 µM -1.50489282432819 0.0772595194205185 no 3053 0.0661758167240086 1024 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_789 1309-1135 70.6 µM -1.50587732646669 0.0771205143383374 no 3054 0.0660493340321494 1010 3092424
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.50823553077781 0.0767883246483231 no 3055 0.0657471283219449 1008 688664
SGTC_1896 st058441 89 µM -1.50875363140184 0.0767154881133902 no 3056 0.0656808771596519 1008 688759
SGTC_1154 4088-0362 150 µM -1.51152020611078 0.076327441639646 no 3057 0.065327982222099 1031 6618304
SGTC_1165 k072-0275 30.3 µM -1.51270040702901 0.0761623590055015 no 3058 0.0651778880780087 1022 6153523 YGL055W OLE1
SGTC_1944 st076371 56.9 µM -1.51596511011654 0.0757071187425064 no 3059 0.0647640874475626 1021 24208455
SGTC_1562 morin hydrate 59.1 µM -1.51842804468912 0.0753650535172402 no 3060 0.0644532631160155 1017 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3067 9117431 49.47 µM -1.52147508454245 0.0749434964662241 no 3061 0.0640703295747162 1041 17150885
SGTC_810 3825-7150 143 µM -1.52158288569996 0.0749286152181388 no 3062 0.0640568142441714 993 22330411 YGL099W LSG1
SGTC_2805 7950783 58.44 µM -1.52555436827803 0.0743819476381295 no 3063 0.0635604418677922 1016 1178958 YDL195W SEC31
SGTC_700 3453-2283 142 µM -1.52601357219507 0.0743189359468501 no 3064 0.0635032422342561 1019 565664
SGTC_1474 0330-0125 5.35 µM -1.52867542472872 0.0739544807908027 no 3065 0.0631724637722001 1044 X1474
SGTC_3035 9091303 49.47 µM -1.53055515502602 0.0736979359502618 no 3066 0.0629396861042588 1042 25237002
SGTC_2706 st078239 82.5 µM -1.53186593564303 0.0735194441207245 no 3067 0.0627777605277261 1035 15434492
SGTC_978 1416-0512 87.4 µM -1.53427448216192 0.0731923291571496 no 3068 0.0624810703561896 1048 6814003
SGTC_3229 9132204 49.47 µM -1.53738405809299 0.0727716527748774 no 3069 0.0620996439673979 1047 17682924
SGTC_2382 9035899 200 µM -1.53767059059088 0.0727329828101415 no 3070 0.0620645889660426 1032 6462679
SGTC_429 1112-0049 25.5 µM -1.53952389527356 0.0724832437138296 no 3071 0.0618382244587874 1024 2836170
SGTC_332 4112-0506 40.9 µM -1.53973813853113 0.0724544161180812 no 3072 0.0618120981783161 1039 2790355
SGTC_609 0986-0026 86.3 µM -1.54087446387229 0.0723016641801153 no 3073 0.0616736709527954 1006 2848610
SGTC_291 SEC14.278 35.5 µM -1.54833468630545 0.071304936257106 no 3074 0.0607708686973356 1028 1068044
SGTC_1130 3454-2858 15.9 µM -1.54962710580275 0.0711333387868864 no 3075 0.0606155215961187 1019 715628 YIL048W NEO1
SGTC_198 3454-2873 16.191 µM -1.55118674859746 0.0709266838993944 no 3076 0.0604284684303462 1020 710957
SGTC_3196 9111891 49.47 µM -1.5585218472561 0.0699609526506434 no 3077 0.0595547965853923 1039 18891510
SGTC_2344 7990960 76.95 µM -1.56336187588728 0.0693292814095376 no 3078 0.0589837510023934 995 140813
SGTC_493 zm226600 134 µM -1.56528417911799 0.0690796243746506 no 3079 0.0587581455319332 1031 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1993 st073995 70.8 µM -1.56684161620942 0.0688778624498906 no 3080 0.0585758586039592 1034 3098394
SGTC_782 0083-0095 30.5 µM -1.56714247971515 0.0688389387738073 no 3081 0.0585406958946766 1036 3591729 An indicator and reagent.
SGTC_923 1900-2434 73.3 µM -1.56760964192249 0.0687785341136828 no 3082 0.0584861302668002 1023 5910570
SGTC_2794 7785382 27.27 µM -1.57555636603367 0.0677572620492821 no 3083 0.0575640393504496 1009 2205081
SGTC_1645 Cervolide 78 µM -1.57699031074362 0.0675742328041223 no 3084 0.0573988772796265 1031 23173 A fragrance.
SGTC_2713 st079149 53.4 µM -1.57869207944413 0.0673575143816672 no 3085 0.0572033512275349 1035 3103253
SGTC_969 1313-0238 134 µM -1.57901499406182 0.0673164522617029 no 3086 0.0571663089396885 1018 5212874
SGTC_250 brefeldin a 552.239 µM -1.57950665187579 0.0672539697654725 no 3087 0.0571099459865846 1049 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1392 3455-1037 33.9 µM -1.58330798195026 0.0667723889296672 no 3088 0.0566756422585481 1010 981132
SGTC_3123 9126162 49.47 µM -1.58340184732341 0.0667605312103581 no 3089 0.0566649511049858 1015 25239884
SGTC_1189 1431-2119 7.28 µM -1.58430555340397 0.0666464521897627 no 3090 0.056562101330705 1032 3107275
SGTC_656 4090-1979 187 µM -1.58448497012614 0.0666238215428215 no 3091 0.0565416996261702 1030 22330961
SGTC_948 3448-0295 75.3 µM -1.585243994944 0.0665281480897763 no 3092 0.0564554540931027 1011 678569
SGTC_2511 berberine 10.47 µM -1.58965807442597 0.0659738690747202 no 3093 0.0559559494465412 1019 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2105 5350118 200 µM -1.59025477928884 0.0658992157916322 no 3094 0.0558886936375432 1031 2133313
SGTC_1049 3226-0134 66 µM -1.59148691301087 0.0657452716655021 no 3095 0.0557500191711716 1033 5702385
SGTC_1260 0700-1617 7.75 µM -1.5924434253642 0.0656259562933056 no 3096 0.0556425527240258 1007 2853078
SGTC_1173 0443-0020 122 µM -1.59713732363011 0.0650428712433706 no 3097 0.0551175500177973 1043 5331295
SGTC_665 3914-0008 307 µM -1.6004088316736 0.0646388617643525 no 3098 0.0547539585788506 1041 1069549
SGTC_3184 9108758 49.47 µM -1.6080564190886 0.0637020403783669 no 3099 0.0539114114080709 1049 902885
SGTC_743 1275-0778 158 µM -1.60889065436722 0.0636004897131612 no 3100 0.0538201266870099 1018 2849257 YMR203W TOM40
SGTC_999 SEC7.066 22.7 µM -1.61325643658042 0.0630711004250859 no 3101 0.0533444033774029 1044 740511 YDR170C SEC7
SGTC_676 falcarinol 140 µM -1.61355658260041 0.0630348315566018 no 3102 0.0533118203904425 1021 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2659 sanguinarine 24.21 µM -1.6153471830526 0.0628187974675169 no 3103 0.0531177656025202 989 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_462 ag-879 158 µM -1.61568088012486 0.0627786011113332 no 3104 0.0530816634571081 1033 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1017 4239-0030 168 µM -1.61854023917292 0.0624349907150293 no 3105 0.0527731111118785 1032 1149593
SGTC_418 lividomycin a 100 µM -1.62061737232621 0.0621863016102934 no 3106 0.0525498620684831 1031 72394 An antibiotic.
SGTC_1233 0325-0408 14.2 µM -1.62216881210883 0.0620010568768578 no 3107 0.0523836037821025 1038 12874
SGTC_688 0527-0193 473 µM -1.62315010803489 0.0618841108516786 no 3108 0.0522786601108163 1052 4007154
SGTC_284 0988-0104 32.6 µM -1.62442327870139 0.0617326373033251 no 3109 0.0521427511004357 1028 4666532
SGTC_2006 4011487 200 µM -1.63536635015756 0.0604426106379181 no 3110 0.0509861360358815 1032 45595294
SGTC_792 4534-1957 155 µM -1.64235901125073 0.0596293888196247 no 3111 0.0502578120962432 1035 1717904
SGTC_722 3534-0461 190 µM -1.64260853649808 0.0596005291321806 no 3112 0.0502319767103273 1031 658262
SGTC_2600 tangeritin 87.95 µM -1.64763623595181 0.059021362676832 no 3113 0.049713669972668 1026 68077 A bioactive flavone.
SGTC_1240 0356-0016 42.1 µM -1.65342463528435 0.0583600451730949 no 3114 0.0491222362703998 984 4305613
SGTC_1816 st051957 91.6 µM -1.65442449613553 0.0582464040456569 no 3115 0.0490206463394884 1063 674121
SGTC_2202 7226349 200 µM -1.65506063838998 0.058174192593256 no 3116 0.0489560991082556 1030 844334
SGTC_2759 disulfiram 3.38 µM -1.65543738420854 0.0581314596057668 no 3117 0.0489179039954231 1020 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2267 7931562 200 µM -1.65671605961613 0.0579866077265424 no 3118 0.0487884472886828 1043 934880
SGTC_1396 3511-0007 98.6 µM -1.65844750985568 0.0577909165789236 no 3119 0.0486135869442298 1034 X1396
SGTC_2137 5261020 140 µM -1.66309727418021 0.0572679621268619 no 3120 0.0481464827270093 1037 763655
SGTC_1756 st041558 35.5 µM -1.66451123671118 0.0571096757218694 no 3121 0.0480051537050099 1040 3955792
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.66895362182674 0.0566146116886854 no 3122 0.0475632857324678 1011 6708739 YPR165W RHO1
SGTC_711 k292-0785 179 µM -1.67156862499047 0.0563247777942657 no 3123 0.0473047079745854 1028 4146315
SGTC_2451 5856223 45.7 µM -1.67964601298661 0.055436902168542 no 3124 0.0465131047647165 1030 2179896
SGTC_3170 9103054 49.47 µM -1.68123949516316 0.0552630568746697 no 3125 0.0463582024510856 1014 16432970
SGTC_2248 tofa 1.1 µM -1.68295591903789 0.0550762809008914 no 3126 0.0461918125882544 1009 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_823 0417-1665 178 µM -1.68396662407536 0.0549665326050299 no 3127 0.046094059573326 1047 3429856
SGTC_419 nsc-638432 893 µM -1.68613177498767 0.054732009454775 no 3128 0.0458852105181238 1044 368090
SGTC_2756 carbadox 75.1 µM -1.68892551756963 0.0544305686955078 no 3129 0.045616852224316 1007 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1571 st070080 73.4 µM -1.69127241479082 0.0541783581616108 no 3130 0.0453923930052484 1032 4315245
SGTC_1547 harmine 94.2 µM -1.69769796277785 0.0534925639388526 no 3131 0.0447823912379238 1019 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_914 3820-6779 408 µM -1.69861397295264 0.0533953614521277 no 3132 0.0446959709761564 1033 2893481
SGTC_931 2812-0076 566 µM -1.69961246244141 0.0532895661705099 no 3133 0.0446019223161773 1048 3450959
SGTC_21 0849-0113 22.993 µM -1.70222954519204 0.0530130606779189 no 3134 0.0443561731419292 1051 1560156
SGTC_2047 4141938 200 µM -1.70276962751707 0.0529561406478488 no 3135 0.0443055944362767 1052 3807862
SGTC_1195 1502-0147 41.1 µM -1.70659743405009 0.0525541107676 no 3136 0.0439484512184724 1034 817940
SGTC_1628 st004252 77.7 µM -1.71171787554439 0.052020109001056 no 3137 0.0434743363813169 1035 692968
SGTC_2404 5161160 200 µM -1.713228310467 0.0518634144748681 no 3138 0.043335272623134 1027 2831543
SGTC_2962 9082311 13.18 µM -1.71450581469939 0.0517311774778221 no 3139 0.0432179350431259 1043 16459453
SGTC_1733 st037357 54.9 µM -1.72098530311994 0.0510645948241692 no 3140 0.0426267454211517 1032 1272339 YGL099W LSG1
SGTC_480 am 92016 50 µM -1.72126852051866 0.0510356152649681 no 3141 0.0426010545082407 1057 2129 K+ channel blocker.
SGTC_1629 st005085 44.9 µM -1.72607864682253 0.0505454265454545 no 3142 0.042166632393153 1022 24207091
SGTC_366 0181-0206 4.31 µM -1.7278942459846 0.0503613809978634 no 3143 0.0420035930639548 1047 274874
SGTC_2357 9067248 200 µM -1.74337207378109 0.0488140063481278 no 3144 0.0406343215507103 1055 9150235
SGTC_614 0462-0418 107 µM -1.74546148650164 0.0486080625205926 no 3145 0.0404522854182238 1026 5188303
SGTC_1711 st032263 62.8 µM -1.74776405189593 0.048381914383855 no 3146 0.0402524462256127 1050 3958979
SGTC_1349 flufenamic acid 69 µM -1.74935680804451 0.0482259736434452 no 3147 0.0401146809801203 1045 3371 A non-steroidal anti-inflammatory.
SGTC_600 1495-0418 41.6 µM -1.76050363689929 0.0471458543842071 no 3148 0.0391612257030652 1051 5377768
SGTC_3191 9110352 49.47 µM -1.76826804353453 0.0464050131029234 no 3149 0.0385080518081459 1033 17122424
SGTC_990 3985-0011 41.3 µM -1.77656501719354 0.0456237159708287 no 3150 0.0378199178411094 1025 5399565 YGL099W LSG1
SGTC_1522 st012842 45.6 µM -1.78606369148023 0.0447422801309172 no 3151 0.0370444730872143 989 3491067 YOR116C RPO31
SGTC_425 3825-7017 13.1 µM -1.78635860913147 0.0447151341073342 no 3152 0.0370206064271889 1048 3397440
SGTC_1619 st003326 88.7 µM -1.79214754782814 0.0441849652001884 no 3153 0.0365546670631037 1003 2849032
SGTC_2087 5276107 200 µM -1.79502391470438 0.0439234294023302 no 3154 0.0363249448938925 1044 144405
SGTC_1161 k007-0610 110 µM -1.79899823284011 0.0435641175117632 no 3155 0.0360094801249088 1025 5843850
SGTC_435 c-PAF 6.7 µM -1.80050716569452 0.0434283201186456 no 3156 0.0358902965738072 1038 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_601 0986-0029 62.9 µM -1.80121817417144 0.0433644510031588 no 3157 0.0358342494581326 1027 24747981
SGTC_34 0469-0683 81.75 µM -1.801793096693 0.0433128618137598 no 3158 0.0357889821314453 1043 3690923
SGTC_55 0767-0285 6.563 µM -1.80400876246996 0.0431145080985783 no 3159 0.0356149666515801 1037 3116166
SGTC_954 1189-0853 2.85 µM -1.80812274790552 0.042748156957905 no 3160 0.0352936992394781 1036 2828194
SGTC_3349 9149703 23.001 µM -1.80854568255249 0.0427106376206256 no 3161 0.0352608067997799 1057 4910494
SGTC_922 1866-0035 480 µM -1.8158296936967 0.0420686264965459 no 3162 0.0346982504095361 1020 3156169
SGTC_1829 berberine 14.4 µM -1.81817090385907 0.041863939370817 no 3163 0.0345190078109492 991 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_580 1123-0028 41 µM -1.82193007064863 0.0415369708182396 no 3164 0.0342327984559022 1063 1677248 YPR107C YTH1
SGTC_721 1187-1332 279 µM -1.83043844848927 0.0408045596020713 no 3165 0.0335922014135203 1066 25730
SGTC_64 000l-0018 272.079 µM -1.83171573783063 0.0406955191221379 no 3166 0.0334968913526565 1034 6811119
SGTC_995 3931-2021 34.6 µM -1.83796046282453 0.0401658147823076 no 3167 0.0330341157531055 1056 730143
SGTC_1675 st018485 24.5 µM -1.83989349291083 0.0400029867918277 no 3168 0.0328919377712251 1052 3323024
SGTC_2701 st077767 14.721 µM -1.84082117093633 0.0399250349179004 no 3169 0.0328238846418049 1046 5721188
SGTC_2234 tolnaftate 200 µM -1.84265787421164 0.0397710627415763 no 3170 0.0326894891191571 1085 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3249 9135183 49.47 µM -1.8429192344167 0.0397491920121294 no 3171 0.0326704017617972 1014 4902779
SGTC_512 prima-1 270 µM -1.84756933564753 0.0393617017000218 no 3172 0.0323323345705942 1056 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1044 1222-0021 1.78 µM -1.85075088345705 0.0390983601253438 no 3173 0.0321027000459664 1007 4306703
SGTC_1819 st053448 58.6 µM -1.85503818541503 0.0387457640151632 no 3174 0.031795386929148 1073 2857616
SGTC_1290 0986-0249 10.2 µM -1.85861709118139 0.0384534153452698 no 3175 0.0315407163878743 1050 53329
SGTC_1377 2944-0135 198 µM -1.86486021378938 0.0379477412084197 no 3176 0.0311005002534945 1035 1894137
SGTC_638 3970-0837 4.09 µM -1.86929563020607 0.0375917927296971 no 3177 0.0307908478761821 1050 4118451 YLR208W SEC13
SGTC_3316 9136639 10.545 µM -1.87216593280152 0.0373629031328072 no 3178 0.0305918253065407 1035 4903665
SGTC_741 4582-0002 126 µM -1.87408298376641 0.0372106647239175 no 3179 0.0304594941475255 1054 2912688
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.8845232402834 0.0363904475042753 no 3180 0.0297471171206557 1019 688669
SGTC_2645 abamectin 100 µM -1.88655519492117 0.0362325441374922 no 3181 0.0296100889787164 989 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1068 loratadine 26.9 µM -1.89311548375132 0.0357265685541794 no 3182 0.0291712567456242 1068 3957 A H1 histamine antagonist.
SGTC_1042 0350-0096 82 µM -1.89445115326819 0.0356242651267592 no 3183 0.0290825760715249 1055 3122515
SGTC_311 1315-0136 58 µM -1.89801155341086 0.0353527347851817 no 3184 0.0288472800512305 1061 6759207
SGTC_582 0987-0078 156 µM -1.90073670561114 0.0351460525407981 no 3185 0.0286682540970753 1064 1625765
SGTC_1504 k297-0033 30 µM -1.91242042291203 0.0342711382521929 no 3186 0.0279111452644722 1036 4388117
SGTC_2007 4011539 71.82 µM -1.91323721794015 0.0342106495097909 no 3187 0.027858845457913 1048 45595301
SGTC_2066 5222451 176 µM -1.91558256732895 0.0340374494726931 no 3188 0.0277091251227014 1005 2281147
SGTC_2473 5854593 8.94 µM -1.91753750366829 0.0338936323687107 no 3189 0.0275848405824201 1058 2872951
SGTC_1925 st057770 10.1 µM -1.91981418339613 0.0337267762446958 no 3190 0.0274406873352075 1053 5989122
SGTC_1353 1498-1206 8.11 µM -1.92121112320619 0.0336247306008189 no 3191 0.0273525482101321 950 6756808
SGTC_217 ketoconazole 989 nM -1.92600801642395 0.0332762530626812 no 3192 0.0270516864447021 1037 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_615 k087-0205 167 µM -1.93635395702267 0.032534777521347 no 3193 0.0264121822711692 1063 9642773
SGTC_3135 9127742 49.47 µM -1.93667374582394 0.0325120777255258 no 3194 0.026392618502623 1047 3643468
SGTC_354 2783-3500 4.88 µM -1.95503103419822 0.0312307454291974 no 3195 0.0252897036845106 1059 6740761
SGTC_3032 9089427 49.47 µM -1.95710491210671 0.0310886519614666 no 3196 0.0251675675187814 1011 17173707
SGTC_3343 9148379 18.9835 µM -1.96310223230228 0.0306807477533241 no 3197 0.0248171481150522 1029 1955036
SGTC_2348 9022543 33.42 µM -1.9637232424983 0.0306387644842981 no 3198 0.0247810978496959 1039 3162678 YDL140C RPO21
SGTC_3005 9076496 71.4286 µM -1.9663735787804 0.0304601234811865 no 3199 0.0246277365634159 1068 21368410
SGTC_750 4073-0104 132 µM -1.966708536565 0.0304376078148087 no 3200 0.0246084110894115 996 22330957
SGTC_3319 9138450 16.7555 µM -1.97669711813121 0.029772491762527 no 3201 0.0240379383825279 1048 2029690
SGTC_2452 5863136 48.41 µM -1.98203922780463 0.0294217509765542 no 3202 0.0237374251830046 1058 2184096
SGTC_1865 st057639 52.2 µM -1.98210784541352 0.0294172682414493 no 3203 0.0237335858336775 1070 688818
SGTC_335 4077-0256 27.6 µM -1.98228993383127 0.029405375295532 no 3204 0.0237234000027197 1048 3121989
SGTC_3036 9090181 49.47 µM -1.9828230577851 0.0293705777234624 no 3205 0.0236935987530495 1073 25236586
SGTC_330 1488-0319 80.1 µM -1.98292289711651 0.0293640649060552 no 3206 0.0236880213065583 1053 6846614
SGTC_1289 0976-0073 69.1 µM -1.99144860086352 0.0288123151649725 no 3207 0.0232157953242094 1069 3391136
SGTC_297 0986-0032 24 µM -2.00419518947674 0.0280035031999769 no 3208 0.0225245778420542 1053 2847425
SGTC_896 0964-0007 44.5 µM -2.00441444369457 0.0279897579607232 no 3209 0.0225128416847706 1056 6756758
SGTC_1926 methyl fluorone black 53.6 µM -2.02213679445117 0.0268971659487999 no 3210 0.0215811108765385 1019 72721 Reacts with homocysteine.
SGTC_703 3875-0075 71.8 µM -2.02284688468185 0.0268541410703513 no 3211 0.021544468076447 1085 2850814
SGTC_860 0443-0016 25.1 µM -2.03550076150997 0.0260970188862855 no 3212 0.0209002560023593 1068 5337942
SGTC_1605 st000082 49.1 µM -2.04322941129523 0.025643431480094 no 3213 0.0205148667743271 1052 1114022
SGTC_1405 3909-7894 12 µM -2.04980583232267 0.0252626822785745 no 3214 0.0201916911243146 1030 7104060
SGTC_1383 3049-0032 20.7 µM -2.0549698400306 0.0249670366032326 no 3215 0.0199409589422892 1055 712864
SGTC_1728 st035614 33.7865 µM -2.06570047678666 0.024361964940967 no 3216 0.0194283851271236 1057 15945546
SGTC_1943 st076331 65.2 µM -2.06635484742964 0.024325468505981 no 3217 0.0193974930329826 1084 24208415
SGTC_2790 5423970 71.43 µM -2.06703388032448 0.0242876451227105 no 3218 0.0193654807937658 1059 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_628 1636-0253 16 µM -2.0769991926825 0.0237382158774956 no 3219 0.0189008168664046 1052 4456143
SGTC_2044 5102272 200 µM -2.07736719090481 0.0237181283316707 no 3220 0.018883840968176 1073 592666
SGTC_1070 indatraline 8.81 µM -2.08821082962246 0.0231326018935108 no 3221 0.0183894104243518 1062 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1107 amlodipine 47 µM -2.09372301112595 0.0228396556542483 no 3222 0.018142330924688 958 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1046 2001-0062 216 µM -2.10835030335628 0.0220774002841754 no 3223 0.0175003498780633 1072 739778
SGTC_171 k064-0041 9.68 µM -2.12277237285469 0.0213469751954521 no 3224 0.0168864654906567 1050 53325
SGTC_1080 nisoldipine 24.4 µM -2.12956369376119 0.0210101597148295 no 3225 0.0166038255711637 1072 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_521 r062-0005 13.8 µM -2.13502327680671 0.0207426627394666 no 3226 0.016379554419463 1072 2832033
SGTC_924 2046-0044 21.3 µM -2.13631416126491 0.020679838013376 no 3227 0.0163269076875754 1069 3623589
SGTC_398 bronopol 33.3 µM -2.14757928972376 0.0201383954136873 no 3228 0.0158735960607119 1072 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1473 k844-0725 134 µM -2.1566086906756 0.0197131344562182 no 3229 0.0155180834092646 1075 54682906
SGTC_870 0573-2213 57.6 µM -2.1576244591996 0.0196657749874893 no 3230 0.0154785207218772 1067 3916321
SGTC_1036 k216-0215 33.5 µM -2.16515180374072 0.0193178194926949 no 3231 0.0151880309359042 984 622330
SGTC_1404 3909-7820 48.3 µM -2.16878686391395 0.0191516689394742 no 3232 0.0150494344962693 1034 23741373
SGTC_227 fluconazole 33.516 µM -2.18751363942723 0.018314835489564 no 3233 0.0143525243113396 1071 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1827 berberine 7.24 µM -2.19345527614539 0.0180559210649958 no 3234 0.014137296750675 1030 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2100 5377183 190 µM -2.19412862754006 0.0180267767272626 no 3235 0.0141130818711656 1053 2844202
SGTC_1045 1348-1485 165 µM -2.19426959877259 0.0180206802186188 no 3236 0.0141080168291101 1070 6810614
SGTC_1706 st031321 9.9705 µM -2.19752598176418 0.0178803416561216 no 3237 0.0139914514919919 1076 6103185
SGTC_256 clotrimazole 625 nM -2.20137618147629 0.0177156153132063 no 3238 0.0138547018796999 1063 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_252 miconazole 1.30953 nM -2.20837419585346 0.0174195280033813 no 3239 0.0136090995272189 1049 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2016 5121758 140 µM -2.22936102157352 0.0165567845996114 no 3240 0.0128949467549523 1063 2795203
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.23258407898829 0.0164275827547087 no 3241 0.0127881924878708 1059 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_215 1287-0124 461.5 µM -2.23726631040448 0.0162414258172917 no 3242 0.0126344698575494 1086 5560863
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.24169682143094 0.0160669436939811 no 3243 0.0124904867302673 1083 279621
SGTC_459 nigericin 15.3 µM -2.24268727448364 0.0160281581864606 no 3244 0.0124584939100666 1077 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1368 1852-0141 284 µM -2.26361807475124 0.0152270916789932 no 3245 0.0117988075943215 1068 2838987
SGTC_744 1594-0068 283 µM -2.27413742774592 0.0148376467584836 no 3246 0.0114788624849616 1074 668392
SGTC_3074 9116018 49.47 µM -2.28366958561575 0.0144921775571055 no 3247 0.0111954784061898 1079 17027303
SGTC_2965 9082772 38.63 µM -2.29086684443278 0.0142359394558128 no 3248 0.0109855580570485 944 16459634
SGTC_1758 st042942 75.2445 µM -2.30543347445096 0.0137292579905972 no 3249 0.0105711542747547 1079 669317
SGTC_2163 5671233 125 µM -2.30656960013385 0.0136904015844831 no 3250 0.0105394129521715 1064 701023
SGTC_2467 5474540 200 µM -2.31590961192684 0.0133745465114568 no 3251 0.0102816022033459 1065 5413519
SGTC_490 phenamil 164 µM -2.32488620341077 0.0130769318890892 no 3252 0.0100390229479295 1006 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1269 0831-0796 3.05 µM -2.32724937176225 0.0129995405282749 no 3253 0.00997599833469667 1045 927758
SGTC_127 0180-0333 59.125 µM -2.32983660974656 0.012915265490886 no 3254 0.00990739421130962 1044 771601
SGTC_2472 5377652 49.4 µM -2.33875058800738 0.0126285152839482 no 3255 0.0096741726734703 1083 1610903
SGTC_2567 aureobasidin a 60 nM -2.3405192407533 0.0125722800248532 no 3256 0.00962847306827246 1057 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_322 k048-0136 19.3 µM -2.34661806286127 0.0123800240835602 no 3257 0.00947233161461132 1086 6823282
SGTC_2155 5570423 76 µM -2.34750800065818 0.0123521841624866 no 3258 0.00944973362951605 1080 797402
SGTC_1159 4092-0538 61.2 µM -2.34785983817586 0.0123411925984016 no 3259 0.0094408125133555 1077 717301
SGTC_2475 5812728 15.03 µM -2.34911255554783 0.0123021258994117 no 3260 0.00940910865392736 1078 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_500 h-89 112 µM -2.35186276484894 0.0122167347092012 no 3261 0.00933983261625431 1079 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1226 3909-7979 35.4 µM -2.35594174340604 0.012091032587403 no 3262 0.00923790747993402 1073 6615510
SGTC_1237 0330-0133 46.1 µM -2.36157346919152 0.0119193230122967 no 3263 0.00909878287315874 1075 X1237 YHR072W ERG7
SGTC_2180 6301957 200 µM -2.36720516255294 0.0117497335865451 no 3264 0.00896149711699182 1073 845462
SGTC_2131 toluylene red 5.2905 µM -2.36944415290027 0.0116828940242993 no 3265 0.00890742266201604 1069 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1947 st076332 61.6 µM -2.37319504960445 0.011571659711108 no 3266 0.00881747427188847 1082 24208416
SGTC_3302 9125395 16.351 µM -2.38359582447037 0.011268018268098 no 3267 0.00857221016495235 1075 17599668
SGTC_1732 st034308 51.822 µM -2.38589526975134 0.0112018305715749 no 3268 0.00851880112453733 1062 830119
SGTC_2377 9073351 62.6 µM -2.39781551426087 0.0108641065442183 no 3269 0.00824658488144787 1078 7337946 YHR072W ERG7
SGTC_2054 5233173 129 µM -2.40547660195409 0.0106517612553667 no 3270 0.00807569310298995 965 6889
SGTC_348 k064-0012 10.7 µM -2.40708577839319 0.0106076213305679 no 3271 0.00804019620901007 1070 5066323
SGTC_3353 9151644 39.2805 µM -2.4071360978485 0.0106062436340392 no 3272 0.0080390884249022 1081 4909158
SGTC_2431 5490079 200 µM -2.41158140754033 0.0104851489411053 no 3273 0.00794175276261231 1083 5722345
SGTC_674 0498-0004 451 µM -2.41979035982178 0.0102646929777631 no 3274 0.00776472855685061 1047 4231473
SGTC_315 k915-0449 187 µM -2.436002418839 0.00984115768134894 no 3275 0.00742529261075126 1072 20970215 YNL149C PGA2
SGTC_3345 9148410 3.559 µM -2.44108525035097 0.00971155109007991 no 3276 0.00732159878805964 1071 4903596
SGTC_1228 0124-0032 52.5 µM -2.46257835885699 0.00917984735009655 no 3277 0.00689710135749165 1082 X1228
SGTC_1128 3448-9350 235 µM -2.46404211050114 0.00914458152736516 no 3278 0.00686899849887645 1071 619386
SGTC_2256 7954252 200 µM -2.47576230412415 0.00886646107563457 no 3279 0.00664760297885433 1083 2972920
SGTC_1476 4112-3294 3.34 µM -2.4902041681429 0.00853397100640618 no 3280 0.00638348656462401 1049 704369
SGTC_467 ro 31-8220 72.8 µM -2.49596427910291 0.00840444091446705 no 3281 0.00628076251929429 1072 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1167 k781-0610 148 µM -2.49781481649649 0.00836319498213702 no 3282 0.00624807266166228 1082 4525169
SGTC_1612 st002233 45.4 µM -2.51823184719891 0.00791979180913658 no 3283 0.00589728275023241 1075 1035021
SGTC_97 0535-0701 19.132 µM -2.52178403143161 0.00784479621319657 no 3284 0.00583806849902558 1054 2832013 YGL099W LSG1
SGTC_1171 0368-0077 21.4 µM -2.52512785841852 0.0077747711397175 no 3285 0.00578281010543334 1079 3239779
SGTC_473 2-arachidonoylglycerol 10 µM -2.52837789466215 0.00770723789316285 no 3286 0.00572954692924314 1058 5282280 An endocannabinoid.
SGTC_246 cycloheximide 667 µM -2.54927058177657 0.00728530356952678 no 3287 0.00539742547520239 1083 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_908 3448-7491 47.7 µM -2.55378062849236 0.00719694099127099 no 3288 0.00532801849298631 1049 1203031
SGTC_1152 3909-8331 15.9 µM -2.55652723431136 0.00714359274643088 no 3289 0.00528613974129412 1080 16001939
SGTC_2082 5219693 150 µM -2.5675271828981 0.00693341727783888 no 3290 0.0051213379170327 1083 2834649
SGTC_778 3456-2434 196 µM -2.57764634236935 0.00674491204240784 no 3291 0.00497378749015561 985 5539063
SGTC_1674 st016616 23.6 µM -2.57784499238455 0.00674125725217045 no 3292 0.00497092921122269 1074 625830
SGTC_2484 5809818 12.04 µM -2.61191243008837 0.00613978295678703 no 3293 0.00450186567682511 1081 2870548
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -2.61760074321012 0.0060441242498412 no 3294 0.00442751726202042 1092 91467 include heat shock
SGTC_2247 cerulenin 830 nM -2.62101789213275 0.00598729628531581 no 3295 0.00438338303953912 1077 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2264 7948757 110.76 µM -2.64859881560526 0.00554569327621152 no 3296 0.00404131081398357 1087 2971411
SGTC_203 k066-0004 30.888 µM -2.64974251549225 0.00552802292683714 no 3297 0.00402765680757746 1090 6795412
SGTC_344 k064-0035 6.43 µM -2.67165055426063 0.00519906083928767 no 3298 0.00377396024245871 1063 5088750
SGTC_1676 st018489 23.4 µM -2.67668324903654 0.00512599810058502 no 3299 0.00371774463058027 1077 3696235
SGTC_1767 st044992 70.3 µM -2.68270681068401 0.0050397529338033 no 3300 0.00365144912647671 1081 9600693
SGTC_393 acivicin 6.25 µM -2.69751426237441 0.00483320901531163 no 3301 0.00349296460705223 1054 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_305 1682-2595 20.8 µM -2.70668145625079 0.00470915316434036 no 3302 0.00339797156783078 1084 226033
SGTC_231 b-estradiol 524 µM -2.72426234398944 0.00447915941504347 no 3303 0.00322226464484328 1092 450 A steroid.
SGTC_1696 st025591 34.7925 µM -2.73746006670942 0.00431315408131924 no 3304 0.00309578183062273 1086 2787147
SGTC_2422 chlorphenesin carbamate 384.24 µM -2.74600028216273 0.00420868479759736 no 3305 0.00301633558698052 1075 2724 A muscle relaxant with antifungal properties.
SGTC_818 4072-2707 53.5 µM -2.75370415455245 0.00411639390629361 no 3306 0.00294625032908376 1080 882871
SGTC_852 0418-0143 439 µM -2.77201437497607 0.00390426874223862 no 3307 0.00278552881435804 1055 5369229
SGTC_1373 2887-0003 58.5 µM -2.78136277551311 0.00379978902730986 no 3308 0.00270656049745084 1088 776948
SGTC_2714 st079313 56.9 µM -2.78869856810714 0.00371956529691234 no 3309 0.00264601473786603 1084 2939799
SGTC_1337 1486-1011 40.3 µM -2.79372626612397 0.00366546352013768 no 3310 0.00260522817245417 1086 X1337
SGTC_2153 5569715 200 µM -2.80669151712703 0.0035291911370118 no 3311 0.00250265745147694 1093 2054701
SGTC_1074 carmofur 3.8 µM -2.82144669365411 0.0033796538029697 no 3312 0.0023903791058698 1089 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1393 3470-5649 58.2 µM -2.83271781429883 0.00326928907059914 no 3313 0.00230770549291789 1088 4108395
SGTC_3348 9149464 3.537 µM -2.84485035588812 0.00315412156471085 no 3314 0.00222161459184144 1084 1951442
SGTC_1786 berberine 21.6 µM -2.86182335114682 0.0029991327795535 no 3315 0.00210605799418426 1042 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1067 clotrimazole 1.36 µM -2.88166382780356 0.00282668182664974 no 3316 0.00197790765392171 1088 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_842 0271-0008 11.1 µM -2.88892403548655 0.00276584726616559 no 3317 0.00193281223198768 1081 1221709
SGTC_866 0495-0101 262 µM -2.91205197422234 0.0025798505769339 no 3318 0.00179531442439715 1080 635694
SGTC_825 1988-2224 89.6 µM -2.92868848014001 0.00245312986162157 no 3319 0.00170197693296457 1089 1180859
SGTC_2424 5537928 59.2 µM -2.94073810886107 0.00236489282060189 no 3320 0.00163715619475191 1079 5382802
SGTC_514 4466-0038 2.65 nM -2.94225375108579 0.00235399990184521 no 3321 0.00162916406253352 1073 5722064
SGTC_706 4262-0057 46.9 µM -2.94954539923158 0.00230222704818236 no 3322 0.00159120906411248 1091 883298
SGTC_1387 3342-1166 1.8 µM -2.96104816304881 0.00222264779072306 no 3323 0.00153296995027536 1090 3418228
SGTC_68 0986-0284 82.829 µM -2.96383680321729 0.00220373451326728 no 3324 0.00151914685706413 1067 423278 YIL048W NEO1
SGTC_3000 9075062 71.4286 µM -3.01056394024985 0.00190777904953182 no 3325 0.00130381519514596 1075 17057871
SGTC_416 estradiol valerate 100 µM -3.01944935453376 0.00185576872053012 no 3326 0.0012661731403013 1092 13791 A steroid.
SGTC_363 0455-0021 3.06 µM -3.02018619415658 0.00185151408270226 no 3327 0.00126309667220895 1070 4597466
SGTC_208 k072-0098 12.366 µM -3.03289088852303 0.00177953613228004 no 3328 0.00121111582059187 1085 5948901
SGTC_2459 5811157 9.22 µM -3.06089093330809 0.00162980832634345 no 3329 0.00110339732362876 1090 2870684 YBR192W RIM2
SGTC_116 0155-0182 31.788 µM -3.10222097756584 0.00142969971237835 no 3330 0.000960372607371357 993 771486
SGTC_1406 3909-7906 11.9 µM -3.10418025181518 0.00142079546724078 no 3331 0.000954035228711733 1077 X1406
SGTC_1764 st044502 93.5 µM -3.11831754464863 0.00135803218240309 no 3332 0.000909433600695951 1090 8407
SGTC_410 α-linolenic acid 100 µM -3.12836915151642 0.00131495976298978 no 3333 0.000878896288788312 1094 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1986 st071812 45 µM -3.15972981680717 0.00118847684127413 no 3334 0.00078957752117584 1091 11838594
SGTC_346 4513-0042 7.16 µM -3.16366758244668 0.00117340788227112 no 3335 0.0007789731457665 1088 2827372
SGTC_2481 5478948 45.16 µM -3.23121215805137 0.000940723220525895 yes 3336 0.000616332040039629 1093 77792
SGTC_3339 9145883 14.936 µM -3.26702177516205 0.000835332693774578 yes 3337 0.00054342660136946 1077 2030670
SGTC_2830 7992007 71.43 µM -3.28457120377301 0.00078775220468212 yes 3338 0.000510688431087477 1088 1952075
SGTC_2471 5466956 24.79 µM -3.30631718715838 0.000732258033048296 yes 3339 0.000472655063974266 1091 724419
SGTC_400 oxethazaine 37.5 µM -3.31978678487352 0.000699715505835125 yes 3340 0.000450431113568921 1093 4621 A local anesthetic.
SGTC_618 k072-0232 33.2 µM -3.33834963545788 0.000657050243190997 yes 3341 0.000421388150170862 1080 5872756 YGL099W LSG1
SGTC_2233 sulbentine 40.3845 µM -3.3498709300609 0.000631790610769718 yes 3342 0.000404246120869776 1069 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_765 1319-0117 244 µM -3.407208567964 0.000518894252024054 yes 3343 0.000328154773332456 1089 3487746 YGL099W LSG1
SGTC_504 lovastatin 124 µM -3.44227799529963 0.00045936705854292 yes 3344 0.000288418561602694 1094 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1072 oxiconazole 14.9 nM -3.46672243203923 0.000421688196718857 yes 3345 0.00026342281367723 1088 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2485 5633444 17.78 µM -3.58777100700263 0.000273849030957271 yes 3346 0.000166758501789059 1088 5724239
SGTC_280 3448-3607 3.04 µM -3.68734235258929 0.000190115175724757 yes 3347 0.000113304197134547 1080 626179
SGTC_1664 st014217 9.02 µM -3.72162185212173 0.00016732327225415 yes 3348 9.89736524431697e-05 1093 3982782
SGTC_917 harmaline 728.087 nM -3.94367113062222 7.1312727899738e-05 yes 3349 4.01218412084537e-05 1087 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1568 digitonin 820 nM -4.04874746173316 4.68975960072527e-05 yes 3350 2.57462350175936e-05 1088 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_73 0327-0325 16.231 µM -4.24751632974536 2.06512480939605e-05 yes 3351 1.08076707278166e-05 1077 53298
SGTC_372 0155-0182 15.9 µM -5.03366671451708 5.65908308188809e-07 yes 3352 2.40592981427476e-07 1031 771486
SGTC_2580 diallyl disulphide 81.36 µM -5.59081712170661 3.13549678240809e-08 yes 3353 1.13001757872715e-08 1095 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2582 agaric acid 100 µM -6.95087870752774 8.02472082716383e-12 yes 3354 1.81508946256525e-12 1095 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1766 st045414 44.774 µM -8.09271586109959 2.04218080421261e-15 yes 3355 2.91744347583218e-16 1095 253960
SGTC_2584 androsterone 48.74 µM -10.6399406076398 2.37270678551587e-25 yes 3356 9.71265622413377e-27 1095 2754130 A steroid.